id	sid	tid	token	lemma	pos
fnp-2671	1	1	top	top	ADJ
fnp-2671	1	2	ten	ten	NUM
fnp-2671	1	3	discoveries	discovery	NOUN
fnp-2671	1	4	of	of	ADP
fnp-2671	1	5	the	the	DET
fnp-2671	1	6	year	year	NOUN
fnp-2671	1	7	:	:	PUNCT
fnp-2671	1	8	neurooncology	neurooncology	NOUN
fnp-2671	1	9	feel	feel	VERB
fnp-2671	1	10	free	free	ADJ
fnp-2671	1	11	to	to	PART
fnp-2671	1	12	add	add	VERB
fnp-2671	1	13	comments	comment	NOUN
fnp-2671	1	14	by	by	ADP
fnp-2671	1	15	clicking	click	VERB
fnp-2671	1	16	these	these	DET
fnp-2671	1	17	icons	icon	NOUN
fnp-2671	1	18	on	on	ADP
fnp-2671	1	19	the	the	DET
fnp-2671	1	20	sidebar	sidebar	NOUN
fnp-2671	1	21	free	free	ADJ
fnp-2671	1	22	neuropathology	neuropathology	NOUN
fnp-2671	1	23	1:8	1:8	NUM
fnp-2671	1	24	(	(	PUNCT
fnp-2671	1	25	2020	2020	NUM
fnp-2671	1	26	)	)	PUNCT
fnp-2671	1	27	review	review	VERB
fnp-2671	1	28	top	top	ADJ
fnp-2671	1	29	ten	ten	NUM
fnp-2671	1	30	discoveries	discovery	NOUN
fnp-2671	1	31	of	of	ADP
fnp-2671	1	32	the	the	DET
fnp-2671	1	33	year	year	NOUN
fnp-2671	1	34	:	:	PUNCT
fnp-2671	1	35	neurooncology	neurooncology	NOUN
fnp-2671	1	36	pieter	pieter	NOUN
fnp-2671	1	37	wesseling1,2	wesseling1,2	PROPN
fnp-2671	1	38	1	1	NUM
fnp-2671	1	39	department	department	NOUN
fnp-2671	1	40	of	of	ADP
fnp-2671	1	41	pathology	pathology	PROPN
fnp-2671	1	42	,	,	PUNCT
fnp-2671	1	43	amsterdam	amsterdam	PROPN
fnp-2671	1	44	university	university	PROPN
fnp-2671	1	45	medical	medical	ADJ
fnp-2671	1	46	centers	center	NOUN
fnp-2671	1	47	,	,	PUNCT
fnp-2671	1	48	location	location	NOUN
fnp-2671	1	49	vumc	vumc	NOUN
fnp-2671	1	50	,	,	PUNCT
fnp-2671	1	51	brain	brain	NOUN
fnp-2671	1	52	tumor	tumor	NOUN
fnp-2671	1	53	center	center	PROPN
fnp-2671	1	54	amsterdam	amsterdam	PROPN
fnp-2671	1	55	,	,	PUNCT
fnp-2671	1	56	de	de	X
fnp-2671	1	57	boelelaan	boelelaan	NOUN
fnp-2671	1	58	1117	1117	NUM
fnp-2671	1	59	,	,	PUNCT
fnp-2671	1	60	1081hv	1081hv	ADJ
fnp-2671	1	61	amsterdam	amsterdam	PROPN
fnp-2671	1	62	,	,	PUNCT
fnp-2671	1	63	the	the	DET
fnp-2671	1	64	netherlands	netherlands	PROPN
fnp-2671	1	65	2	2	NUM
fnp-2671	1	66	princess	princess	NOUN
fnp-2671	1	67	máxima	máxima	NOUN
fnp-2671	1	68	center	center	NOUN
fnp-2671	1	69	for	for	ADP
fnp-2671	1	70	pediatric	pediatric	ADJ
fnp-2671	1	71	oncology	oncology	NOUN
fnp-2671	1	72	,	,	PUNCT
fnp-2671	1	73	heidelberglaan	heidelberglaan	NOUN
fnp-2671	1	74	25	25	NUM
fnp-2671	1	75	,	,	PUNCT
fnp-2671	1	76	3584	3584	NUM
fnp-2671	1	77	cs	cs	PROPN
fnp-2671	1	78	utrecht	utrecht	PROPN
fnp-2671	1	79	,	,	PUNCT
fnp-2671	1	80	the	the	DET
fnp-2671	1	81	netherlands	netherlands	PROPN
fnp-2671	1	82	corresponding	corresponding	ADJ
fnp-2671	1	83	author	author	NOUN
fnp-2671	1	84	:	:	PUNCT
fnp-2671	1	85	pieter	pieter	NOUN
fnp-2671	1	86	wesseling	wesseling	PROPN
fnp-2671	1	87	,	,	PUNCT
fnp-2671	1	88	md	md	PROPN
fnp-2671	1	89	,	,	PUNCT
fnp-2671	1	90	phd	phd	NOUN
fnp-2671	1	91	·	·	PUNCT
fnp-2671	1	92	department	department	NOUN
fnp-2671	1	93	of	of	ADP
fnp-2671	1	94	pathology	pathology	PROPN
fnp-2671	1	95	·	·	PUNCT
fnp-2671	1	96	amsterdam	amsterdam	PROPN
fnp-2671	1	97	university	university	PROPN
fnp-2671	1	98	medical	medical	ADJ
fnp-2671	1	99	centers	center	NOUN
fnp-2671	1	100	/	/	SYM
fnp-2671	1	101	vumc	vumc	NOUN
fnp-2671	1	102	·	·	PUNCT
fnp-2671	1	103	de	de	X
fnp-2671	1	104	boelelaan	boelelaan	NOUN
fnp-2671	1	105	1117	1117	NUM
fnp-2671	1	106	·	·	SYM
fnp-2671	1	107	1081	1081	NUM
fnp-2671	1	108	hv	hv	PROPN
fnp-2671	1	109	amsterdam	amsterdam	PROPN
fnp-2671	1	110	·	·	PUNCT
fnp-2671	1	111	the	the	DET
fnp-2671	1	112	netherlands	netherlands	PROPN
fnp-2671	1	113	·	·	PUNCT
fnp-2671	2	1	tel	tel	ADP
fnp-2671	2	2	:	:	PUNCT
fnp-2671	2	3	+31	+31	NUM
fnp-2671	2	4	-	-	PUNCT
fnp-2671	2	5	20	20	NUM
fnp-2671	2	6	-	-	PUNCT
fnp-2671	2	7	4444979	4444979	NUM
fnp-2671	2	8	p.wesseling@amsterdamumc.nl	p.wesseling@amsterdamumc.nl	NOUN
fnp-2671	2	9	submitted	submit	VERB
fnp-2671	2	10	:	:	PUNCT
fnp-2671	2	11	30	30	NUM
fnp-2671	2	12	january	january	NOUN
fnp-2671	2	13	2020	2020	NUM
fnp-2671	2	14	accepted	accept	VERB
fnp-2671	2	15	:	:	PUNCT
fnp-2671	2	16	23	23	NUM
fnp-2671	2	17	february	february	NOUN
fnp-2671	2	18	2020	2020	NUM
fnp-2671	2	19	published	publish	VERB
fnp-2671	2	20	:	:	PUNCT
fnp-2671	2	21	26	26	NUM
fnp-2671	2	22	february	february	NOUN
fnp-2671	2	23	2020	2020	NUM
fnp-2671	2	24	https://doi.org/10.17879/freeneuropathology-2020-2671	https://doi.org/10.17879/freeneuropathology-2020-2671	PROPN
fnp-2671	2	25	keywords	keyword	NOUN
fnp-2671	2	26	:	:	PUNCT
fnp-2671	3	1	brain	brain	NOUN
fnp-2671	3	2	tumor	tumor	NOUN
fnp-2671	3	3	,	,	PUNCT
fnp-2671	3	4	neuropathology	neuropathology	NOUN
fnp-2671	3	5	,	,	PUNCT
fnp-2671	3	6	molecular	molecular	ADJ
fnp-2671	3	7	diagnostics	diagnostic	NOUN
fnp-2671	3	8	,	,	PUNCT
fnp-2671	3	9	glioma	glioma	NOUN
fnp-2671	3	10	,	,	PUNCT
fnp-2671	3	11	medulloblastoma	medulloblastoma	NOUN
fnp-2671	3	12	,	,	PUNCT
fnp-2671	3	13	methylome	methylome	ADJ
fnp-2671	3	14	analysis	analysis	NOUN
fnp-2671	3	15	abstract	abstract	ADV
fnp-2671	3	16	this	this	DET
fnp-2671	3	17	article	article	NOUN
fnp-2671	3	18	briefly	briefly	ADV
fnp-2671	3	19	discusses	discuss	VERB
fnp-2671	3	20	10	10	NUM
fnp-2671	3	21	topics	topic	NOUN
fnp-2671	3	22	that	that	PRON
fnp-2671	3	23	were	be	AUX
fnp-2671	3	24	selected	select	VERB
fnp-2671	3	25	by	by	ADP
fnp-2671	3	26	the	the	DET
fnp-2671	3	27	author	author	NOUN
fnp-2671	3	28	as	as	ADP
fnp-2671	3	29	top	top	ADJ
fnp-2671	3	30	10	10	NUM
fnp-2671	3	31	discoveries	discovery	NOUN
fnp-2671	3	32	published	publish	VERB
fnp-2671	3	33	in	in	ADP
fnp-2671	3	34	2019	2019	NUM
fnp-2671	3	35	in	in	ADP
fnp-2671	3	36	the	the	DET
fnp-2671	3	37	broader	broad	ADJ
fnp-2671	3	38	field	field	NOUN
fnp-2671	3	39	of	of	ADP
fnp-2671	3	40	neuro	neuro	NOUN
fnp-2671	3	41	-	-	PUNCT
fnp-2671	3	42	oncological	oncological	ADJ
fnp-2671	3	43	pathology	pathology	NOUN
fnp-2671	3	44	(	(	PUNCT
fnp-2671	3	45	so	so	ADV
fnp-2671	3	46	including	include	VERB
fnp-2671	3	47	neurosciences	neuroscience	NOUN
fnp-2671	3	48	as	as	ADV
fnp-2671	3	49	well	well	ADV
fnp-2671	3	50	as	as	ADP
fnp-2671	3	51	clinical	clinical	ADJ
fnp-2671	3	52	neuro	neuro	NOUN
fnp-2671	3	53	-	-	PUNCT
fnp-2671	3	54	oncology	oncology	NOUN
fnp-2671	3	55	but	but	CCONJ
fnp-2671	3	56	with	with	ADP
fnp-2671	3	57	implications	implication	NOUN
fnp-2671	3	58	for	for	ADP
fnp-2671	3	59	neuro	neuro	NOUN
fnp-2671	3	60	-	-	PUNCT
fnp-2671	3	61	oncological	oncological	ADJ
fnp-2671	3	62	pathology	pathology	NOUN
fnp-2671	3	63	)	)	PUNCT
fnp-2671	3	64	.	.	PUNCT
fnp-2671	4	1	some	some	DET
fnp-2671	4	2	topics	topic	NOUN
fnp-2671	4	3	concern	concern	VERB
fnp-2671	4	4	new	new	ADJ
fnp-2671	4	5	information	information	NOUN
fnp-2671	4	6	on	on	ADP
fnp-2671	4	7	immunohistochemical	immunohistochemical	ADJ
fnp-2671	4	8	and	and	CCONJ
fnp-2671	4	9	molecular	molecular	ADJ
fnp-2671	4	10	markers	marker	NOUN
fnp-2671	4	11	that	that	PRON
fnp-2671	4	12	enable	enable	VERB
fnp-2671	4	13	improved	improved	ADJ
fnp-2671	4	14	diagnosis	diagnosis	NOUN
fnp-2671	4	15	of	of	ADP
fnp-2671	4	16	particular	particular	ADJ
fnp-2671	4	17	tumors	tumor	NOUN
fnp-2671	4	18	of	of	ADP
fnp-2671	4	19	the	the	DET
fnp-2671	4	20	central	central	ADJ
fnp-2671	4	21	nervous	nervous	ADJ
fnp-2671	4	22	system	system	NOUN
fnp-2671	4	23	(	(	PUNCT
fnp-2671	4	24	cns	cns	NOUN
fnp-2671	4	25	)	)	PUNCT
fnp-2671	4	26	and	and	CCONJ
fnp-2671	4	27	information	information	NOUN
fnp-2671	4	28	on	on	ADP
fnp-2671	4	29	a	a	DET
fnp-2671	4	30	refined	refined	ADJ
fnp-2671	4	31	classification	classification	NOUN
fnp-2671	4	32	of	of	ADP
fnp-2671	4	33	medulloblastomas	medulloblastoma	NOUN
fnp-2671	4	34	.	.	PUNCT
fnp-2671	5	1	subsequently	subsequently	ADV
fnp-2671	5	2	,	,	PUNCT
fnp-2671	5	3	several	several	ADJ
fnp-2671	5	4	papers	paper	NOUN
fnp-2671	5	5	are	be	AUX
fnp-2671	5	6	discussed	discuss	VERB
fnp-2671	5	7	that	that	SCONJ
fnp-2671	5	8	further	far	ADV
fnp-2671	5	9	elucidate	elucidate	VERB
fnp-2671	5	10	some	some	DET
fnp-2671	5	11	pathobiological	pathobiological	ADJ
fnp-2671	5	12	aspects	aspect	NOUN
fnp-2671	5	13	of	of	ADP
fnp-2671	5	14	especially	especially	ADV
fnp-2671	5	15	medulloblastomas	medulloblastoma	NOUN
fnp-2671	5	16	(	(	PUNCT
fnp-2671	5	17	histogenesis	histogenesis	ADJ
fnp-2671	5	18	,	,	PUNCT
fnp-2671	5	19	molecular	molecular	ADJ
fnp-2671	5	20	evolution	evolution	NOUN
fnp-2671	5	21	)	)	PUNCT
fnp-2671	5	22	and	and	CCONJ
fnp-2671	5	23	diffuse	diffuse	VERB
fnp-2671	5	24	gliomas	glioma	NOUN
fnp-2671	5	25	(	(	PUNCT
fnp-2671	5	26	mechanisms	mechanism	NOUN
fnp-2671	5	27	involved	involve	VERB
fnp-2671	5	28	in	in	ADP
fnp-2671	5	29	cns	cns	NOUN
fnp-2671	5	30	infiltration	infiltration	NOUN
fnp-2671	5	31	,	,	PUNCT
fnp-2671	5	32	role	role	NOUN
fnp-2671	5	33	of	of	ADP
fnp-2671	5	34	cancer	cancer	NOUN
fnp-2671	5	35	stem(-like	stem(-like	NOUN
fnp-2671	5	36	)	)	PUNCT
fnp-2671	5	37	cells	cell	NOUN
fnp-2671	5	38	,	,	PUNCT
fnp-2671	5	39	longitudinal	longitudinal	ADJ
fnp-2671	5	40	molecular	molecular	ADJ
fnp-2671	5	41	evolution	evolution	NOUN
fnp-2671	5	42	)	)	PUNCT
fnp-2671	5	43	.	.	PUNCT
fnp-2671	6	1	the	the	DET
fnp-2671	6	2	remaining	remain	VERB
fnp-2671	6	3	topics	topic	NOUN
fnp-2671	6	4	concern	concern	NOUN
fnp-2671	6	5	progress	progress	NOUN
fnp-2671	6	6	made	make	VERB
fnp-2671	6	7	in	in	ADP
fnp-2671	6	8	vaccination	vaccination	NOUN
fnp-2671	6	9	therapy	therapy	NOUN
fnp-2671	6	10	for	for	ADP
fnp-2671	6	11	glioblastomas	glioblastoma	NOUN
fnp-2671	6	12	and	and	CCONJ
fnp-2671	6	13	in	in	ADP
fnp-2671	6	14	using	use	VERB
fnp-2671	6	15	cerebrospinal	cerebrospinal	ADJ
fnp-2671	6	16	fluid	fluid	NOUN
fnp-2671	6	17	for	for	ADP
fnp-2671	6	18	liquid	liquid	ADJ
fnp-2671	6	19	biopsy	biopsy	NOUN
fnp-2671	6	20	diagnosis	diagnosis	NOUN
fnp-2671	6	21	of	of	ADP
fnp-2671	6	22	gliomas	glioma	NOUN
fnp-2671	6	23	.	.	PUNCT
fnp-2671	7	1	clearly	clearly	ADV
fnp-2671	7	2	,	,	PUNCT
fnp-2671	7	3	substantial	substantial	ADJ
fnp-2671	7	4	,	,	PUNCT
fnp-2671	7	5	and	and	CCONJ
fnp-2671	7	6	sometimes	sometimes	ADV
fnp-2671	7	7	even	even	ADV
fnp-2671	7	8	amazing	amazing	ADJ
fnp-2671	7	9	progress	progress	NOUN
fnp-2671	7	10	has	have	AUX
fnp-2671	7	11	been	be	AUX
fnp-2671	7	12	made	make	VERB
fnp-2671	7	13	in	in	ADP
fnp-2671	7	14	increasing	increase	VERB
fnp-2671	7	15	our	our	PRON
fnp-2671	7	16	understanding	understanding	NOUN
fnp-2671	7	17	in	in	ADP
fnp-2671	7	18	several	several	ADJ
fnp-2671	7	19	areas	area	NOUN
fnp-2671	7	20	of	of	ADP
fnp-2671	7	21	neuro	neuro	NOUN
fnp-2671	7	22	-	-	PUNCT
fnp-2671	7	23	oncological	oncological	ADJ
fnp-2671	7	24	pathology	pathology	NOUN
fnp-2671	7	25	.	.	PUNCT
fnp-2671	8	1	at	at	ADP
fnp-2671	8	2	the	the	DET
fnp-2671	8	3	same	same	ADJ
fnp-2671	8	4	time	time	NOUN
fnp-2671	8	5	,	,	PUNCT
fnp-2671	8	6	almost	almost	ADV
fnp-2671	8	7	every	every	DET
fnp-2671	8	8	finding	finding	NOUN
fnp-2671	8	9	raises	raise	VERB
fnp-2671	8	10	new	new	ADJ
fnp-2671	8	11	questions	question	NOUN
fnp-2671	8	12	,	,	PUNCT
fnp-2671	8	13	and	and	CCONJ
fnp-2671	8	14	translation	translation	NOUN
fnp-2671	8	15	of	of	ADP
fnp-2671	8	16	new	new	ADJ
fnp-2671	8	17	insights	insight	NOUN
fnp-2671	8	18	in	in	ADP
fnp-2671	8	19	improving	improve	VERB
fnp-2671	8	20	the	the	DET
fnp-2671	8	21	outcome	outcome	NOUN
fnp-2671	8	22	for	for	ADP
fnp-2671	8	23	patients	patient	NOUN
fnp-2671	8	24	suffering	suffer	VERB
fnp-2671	8	25	from	from	ADP
fnp-2671	8	26	cns	cns	PROPN
fnp-2671	8	27	tumors	tumor	NOUN
fnp-2671	8	28	remains	remain	VERB
fnp-2671	8	29	a	a	DET
fnp-2671	8	30	huge	huge	ADJ
fnp-2671	8	31	challenge	challenge	NOUN
fnp-2671	8	32	.	.	PUNCT
fnp-2671	9	1	introduction	introduction	NOUN
fnp-2671	9	2	looking	look	VERB
fnp-2671	9	3	back	back	ADV
fnp-2671	9	4	from	from	ADP
fnp-2671	9	5	time	time	NOUN
fnp-2671	9	6	to	to	ADP
fnp-2671	9	7	time	time	NOUN
fnp-2671	9	8	is	be	AUX
fnp-2671	9	9	good	good	ADJ
fnp-2671	9	10	.	.	PUNCT
fnp-2671	10	1	the	the	DET
fnp-2671	10	2	request	request	NOUN
fnp-2671	10	3	of	of	ADP
fnp-2671	10	4	the	the	DET
fnp-2671	10	5	editor	editor	NOUN
fnp-2671	10	6	-	-	PUNCT
fnp-2671	10	7	in	in	ADP
fnp-2671	10	8	-	-	PUNCT
fnp-2671	10	9	chief	chief	NOUN
fnp-2671	10	10	of	of	ADP
fnp-2671	10	11	this	this	DET
fnp-2671	10	12	journal	journal	NOUN
fnp-2671	10	13	to	to	PART
fnp-2671	10	14	contribute	contribute	VERB
fnp-2671	10	15	a	a	DET
fnp-2671	10	16	review	review	NOUN
fnp-2671	10	17	on	on	ADP
fnp-2671	10	18	‘	'	PUNCT
fnp-2671	10	19	top	top	ADJ
fnp-2671	10	20	10	10	NUM
fnp-2671	10	21	discoveries	discovery	NOUN
fnp-2671	10	22	’	'	PUNCT
fnp-2671	10	23	in	in	ADP
fnp-2671	10	24	neuro	neuro	NOUN
fnp-2671	10	25	-	-	PUNCT
fnp-2671	10	26	oncology	oncology	NOUN
fnp-2671	10	27	published	publish	VERB
fnp-2671	10	28	in	in	ADP
fnp-2671	10	29	2019	2019	NUM
fnp-2671	10	30	was	be	AUX
fnp-2671	10	31	the	the	DET
fnp-2671	10	32	reason	reason	NOUN
fnp-2671	10	33	for	for	SCONJ
fnp-2671	10	34	the	the	DET
fnp-2671	10	35	author	author	NOUN
fnp-2671	10	36	to	to	PART
fnp-2671	10	37	look	look	VERB
fnp-2671	10	38	back	back	ADV
fnp-2671	10	39	in	in	ADP
fnp-2671	10	40	a	a	DET
fnp-2671	10	41	somewhat	somewhat	ADV
fnp-2671	10	42	more	more	ADV
fnp-2671	10	43	structured	structured	ADJ
fnp-2671	10	44	way	way	NOUN
fnp-2671	10	45	in	in	ADP
fnp-2671	10	46	order	order	NOUN
fnp-2671	10	47	to	to	PART
fnp-2671	10	48	select	select	VERB
fnp-2671	10	49	which	which	DET
fnp-2671	10	50	topics	topic	NOUN
fnp-2671	10	51	could	could	AUX
fnp-2671	10	52	/	/	PUNCT
fnp-2671	10	53	should	should	AUX
fnp-2671	10	54	qualify	qualify	VERB
fnp-2671	10	55	for	for	ADP
fnp-2671	10	56	such	such	DET
fnp-2671	10	57	a	a	DET
fnp-2671	10	58	label	label	NOUN
fnp-2671	10	59	.	.	PUNCT
fnp-2671	11	1	from	from	ADP
fnp-2671	11	2	the	the	DET
fnp-2671	11	3	start	start	NOUN
fnp-2671	11	4	it	it	PRON
fnp-2671	11	5	was	be	AUX
fnp-2671	11	6	clear	clear	ADJ
fnp-2671	11	7	that	that	SCONJ
fnp-2671	11	8	there	there	PRON
fnp-2671	11	9	are	be	VERB
fnp-2671	11	10	multiple	multiple	ADJ
fnp-2671	11	11	ways	way	NOUN
fnp-2671	11	12	to	to	PART
fnp-2671	11	13	shape	shape	VERB
fnp-2671	11	14	such	such	DET
fnp-2671	11	15	a	a	DET
fnp-2671	11	16	selection	selection	NOUN
fnp-2671	11	17	process	process	NOUN
fnp-2671	11	18	.	.	PUNCT
fnp-2671	12	1	to	to	PART
fnp-2671	12	2	cut	cut	VERB
fnp-2671	12	3	a	a	DET
fnp-2671	12	4	long	long	ADJ
fnp-2671	12	5	story	story	NOUN
fnp-2671	12	6	short	short	ADJ
fnp-2671	12	7	,	,	PUNCT
fnp-2671	12	8	keeping	keep	VERB
fnp-2671	12	9	the	the	DET
fnp-2671	12	10	readership	readership	NOUN
fnp-2671	12	11	of	of	ADP
fnp-2671	12	12	free	free	ADJ
fnp-2671	12	13	neuropathology	neuropathology	NOUN
fnp-2671	12	14	in	in	ADP
fnp-2671	12	15	mind	mind	NOUN
fnp-2671	12	16	and	and	CCONJ
fnp-2671	12	17	with	with	ADP
fnp-2671	12	18	some	some	DET
fnp-2671	12	19	help	help	NOUN
fnp-2671	12	20	of	of	ADP
fnp-2671	12	21	the	the	DET
fnp-2671	12	22	editor	editor	NOUN
fnp-2671	12	23	-	-	PUNCT
fnp-2671	12	24	in	in	ADP
fnp-2671	12	25	-	-	PUNCT
fnp-2671	12	26	chief	chief	NOUN
fnp-2671	12	27	of	of	ADP
fnp-2671	12	28	this	this	DET
fnp-2671	12	29	journal	journal	NOUN
fnp-2671	12	30	,	,	PUNCT
fnp-2671	12	31	the	the	DET
fnp-2671	12	32	choice	choice	NOUN
fnp-2671	12	33	was	be	AUX
fnp-2671	12	34	made	make	VERB
fnp-2671	12	35	to	to	PART
fnp-2671	12	36	select	select	VERB
fnp-2671	12	37	topics	topic	NOUN
fnp-2671	12	38	based	base	VERB
fnp-2671	12	39	on	on	ADP
fnp-2671	12	40	original	original	ADJ
fnp-2671	12	41	papers	paper	NOUN
fnp-2671	12	42	published	publish	VERB
fnp-2671	12	43	in	in	ADP
fnp-2671	12	44	2019	2019	NUM
fnp-2671	12	45	from	from	ADP
fnp-2671	12	46	a	a	DET
fnp-2671	12	47	broad	broad	ADJ
fnp-2671	12	48	range	range	NOUN
fnp-2671	12	49	of	of	ADP
fnp-2671	12	50	journals	journal	NOUN
fnp-2671	12	51	,	,	PUNCT
fnp-2671	12	52	important	important	ADJ
fnp-2671	12	53	criteria	criterion	NOUN
fnp-2671	12	54	being	be	AUX
fnp-2671	12	55	that	that	SCONJ
fnp-2671	12	56	indeed	indeed	ADV
fnp-2671	12	57	relevant	relevant	ADJ
fnp-2671	12	58	progress	progress	NOUN
fnp-2671	12	59	was	be	AUX
fnp-2671	12	60	made	make	VERB
fnp-2671	12	61	and	and	CCONJ
fnp-2671	12	62	that	that	SCONJ
fnp-2671	12	63	in	in	ADP
fnp-2671	12	64	one	one	NUM
fnp-2671	12	65	way	way	NOUN
fnp-2671	12	66	or	or	CCONJ
fnp-2671	12	67	another	another	PRON
fnp-2671	12	68	the	the	DET
fnp-2671	12	69	findings	finding	NOUN
fnp-2671	12	70	can	can	AUX
fnp-2671	12	71	be	be	AUX
fnp-2671	12	72	expected	expect	VERB
fnp-2671	12	73	to	to	PART
fnp-2671	12	74	have	have	VERB
fnp-2671	12	75	substantial	substantial	ADJ
fnp-2671	12	76	implications	implication	NOUN
fnp-2671	12	77	for	for	ADP
fnp-2671	12	78	neuro	neuro	NOUN
fnp-2671	12	79	-	-	PUNCT
fnp-2671	12	80	oncological	oncological	ADJ
fnp-2671	12	81	pathology	pathology	NOUN
fnp-2671	12	82	.	.	PUNCT
fnp-2671	13	1	furthermore	furthermore	ADV
fnp-2671	13	2	,	,	PUNCT
fnp-2671	13	3	it	it	PRON
fnp-2671	13	4	was	be	AUX
fnp-2671	13	5	decided	decide	VERB
fnp-2671	13	6	to	to	PART
fnp-2671	13	7	not	not	PART
fnp-2671	13	8	just	just	ADV
fnp-2671	13	9	focus	focus	VERB
fnp-2671	13	10	on	on	ADP
fnp-2671	13	11	articles	article	NOUN
fnp-2671	13	12	in	in	ADP
fnp-2671	13	13	the	the	DET
fnp-2671	13	14	high(est)-impact	high(est)-impact	PROPN
fnp-2671	13	15	journals	journal	NOUN
fnp-2671	13	16	and	and	CCONJ
fnp-2671	13	17	to	to	PART
fnp-2671	13	18	aim	aim	VERB
fnp-2671	13	19	for	for	ADP
fnp-2671	13	20	a	a	DET
fnp-2671	13	21	somewhat	somewhat	ADV
fnp-2671	13	22	broader	broad	ADJ
fnp-2671	13	23	blend	blend	NOUN
fnp-2671	13	24	of	of	ADP
fnp-2671	13	25	topics	topic	NOUN
fnp-2671	13	26	.	.	PUNCT
fnp-2671	14	1	some	some	DET
fnp-2671	14	2	topics	topic	NOUN
fnp-2671	14	3	presented	present	VERB
fnp-2671	14	4	in	in	ADP
fnp-2671	14	5	this	this	DET
fnp-2671	14	6	review	review	NOUN
fnp-2671	14	7	were	be	AUX
fnp-2671	14	8	selected	select	VERB
fnp-2671	14	9	based	base	VERB
fnp-2671	14	10	on	on	ADP
fnp-2671	14	11	just	just	ADV
fnp-2671	14	12	one	one	NUM
fnp-2671	14	13	article	article	NOUN
fnp-2671	14	14	,	,	PUNCT
fnp-2671	14	15	while	while	SCONJ
fnp-2671	14	16	the	the	DET
fnp-2671	14	17	information	information	NOUN
fnp-2671	14	18	of	of	ADP
fnp-2671	14	19	two	two	NUM
fnp-2671	14	20	or	or	CCONJ
fnp-2671	14	21	three	three	NUM
fnp-2671	14	22	papers	paper	NOUN
fnp-2671	14	23	was	be	AUX
fnp-2671	14	24	combined	combine	VERB
fnp-2671	14	25	for	for	ADP
fnp-2671	14	26	the	the	DET
fnp-2671	14	27	discussion	discussion	NOUN
fnp-2671	14	28	of	of	ADP
fnp-2671	14	29	other	other	ADJ
fnp-2671	14	30	topics	topic	NOUN
fnp-2671	14	31	.	.	PUNCT
fnp-2671	15	1	the	the	DET
fnp-2671	15	2	10	10	NUM
fnp-2671	15	3	topics	topic	NOUN
fnp-2671	15	4	that	that	PRON
fnp-2671	15	5	emerged	emerge	VERB
fnp-2671	15	6	from	from	ADP
fnp-2671	15	7	this	this	PRON
fnp-2671	15	8	(	(	PUNCT
fnp-2671	15	9	quite	quite	ADV
fnp-2671	15	10	subjective	subjective	ADJ
fnp-2671	15	11	!	!	PUNCT
fnp-2671	15	12	)	)	PUNCT
fnp-2671	15	13	selection	selection	NOUN
fnp-2671	15	14	process	process	NOUN
fnp-2671	15	15	are	be	AUX
fnp-2671	15	16	:	:	PUNCT
fnp-2671	15	17	  	  	SPACE
fnp-2671	15	18	1	1	NUM
fnp-2671	15	19	.	.	PUNCT
fnp-2671	15	20	lack	lack	NOUN
fnp-2671	15	21	of	of	ADP
fnp-2671	15	22	h3k27me3	h3k27me3	PROPN
fnp-2671	15	23	staining	stain	VERB
fnp-2671	15	24	is	be	AUX
fnp-2671	15	25	a	a	DET
fnp-2671	15	26	promising	promising	ADJ
fnp-2671	15	27	surrogate	surrogate	ADJ
fnp-2671	15	28	marker	marker	NOUN
fnp-2671	15	29	for	for	ADP
fnp-2671	15	30	oligodendrogliomas	oligodendroglioma	NOUN
fnp-2671	15	31	[	[	X
fnp-2671	15	32	1	1	NUM
fnp-2671	15	33	]	]	SYM
fnp-2671	15	34	2	2	NUM
fnp-2671	15	35	.	.	NUM
fnp-2671	15	36	improved	improve	VERB
fnp-2671	15	37	molecular	molecular	ADJ
fnp-2671	15	38	diagnosis	diagnosis	NOUN
fnp-2671	15	39	of	of	ADP
fnp-2671	15	40	rare	rare	ADJ
fnp-2671	15	41	cns	cns	NOUN
fnp-2671	15	42	tumor	tumor	NOUN
fnp-2671	15	43	types	type	NOUN
fnp-2671	16	1	[	[	X
fnp-2671	16	2	2	2	NUM
fnp-2671	16	3	,	,	PUNCT
fnp-2671	16	4	3	3	NUM
fnp-2671	16	5	]	]	SYM
fnp-2671	16	6	3	3	NUM
fnp-2671	16	7	.	.	NUM
fnp-2671	16	8	refined	refine	VERB
fnp-2671	16	9	molecular	molecular	ADJ
fnp-2671	16	10	classification	classification	NOUN
fnp-2671	16	11	of	of	ADP
fnp-2671	16	12	non	non	NOUN
fnp-2671	16	13	-	-	ADJ
fnp-2671	16	14	wnt	wnt	NOUN
fnp-2671	16	15	/	/	SYM
fnp-2671	16	16	non	non	ADJ
fnp-2671	16	17	-	-	ADJ
fnp-2671	16	18	shh	shh	ADJ
fnp-2671	16	19	medulloblastomas	medulloblastoma	NOUN
fnp-2671	17	1	[	[	X
fnp-2671	17	2	4	4	X
fnp-2671	17	3	]	]	SYM
fnp-2671	17	4	4	4	NUM
fnp-2671	17	5	.	.	X
fnp-2671	17	6	histogenesis	histogenesis	NOUN
fnp-2671	17	7	of	of	ADP
fnp-2671	17	8	posterior	posterior	ADJ
fnp-2671	17	9	fossa	fossa	ADJ
fnp-2671	17	10	tumors	tumor	NOUN
fnp-2671	17	11	in	in	ADP
fnp-2671	17	12	children	child	NOUN
fnp-2671	17	13	[	[	X
fnp-2671	17	14	5	5	NUM
fnp-2671	17	15	-	-	SYM
fnp-2671	17	16	7	7	NUM
fnp-2671	17	17	]	]	SYM
fnp-2671	17	18	5	5	NUM
fnp-2671	17	19	.	.	PUNCT
fnp-2671	17	20	longitudinal	longitudinal	ADJ
fnp-2671	17	21	molecular	molecular	ADJ
fnp-2671	17	22	analysis	analysis	NOUN
fnp-2671	17	23	of	of	ADP
fnp-2671	17	24	diffuse	diffuse	ADJ
fnp-2671	17	25	gliomas	glioma	NOUN
fnp-2671	17	26	[	[	X
fnp-2671	17	27	8	8	NUM
fnp-2671	17	28	]	]	SYM
fnp-2671	17	29	6	6	NUM
fnp-2671	17	30	.	.	PUNCT
fnp-2671	18	1	notch1	notch1	NOUN
fnp-2671	18	2	-	-	PUNCT
fnp-2671	18	3	sox2	sox2	NOUN
fnp-2671	18	4	signaling	signal	VERB
fnp-2671	18	5	controls	control	NOUN
fnp-2671	18	6	glioma	glioma	NOUN
fnp-2671	18	7	cell	cell	NOUN
fnp-2671	18	8	invasion	invasion	NOUN
fnp-2671	18	9	in	in	ADP
fnp-2671	18	10	white	white	ADJ
fnp-2671	18	11	matter	matter	NOUN
fnp-2671	18	12	tracts	tract	NOUN
fnp-2671	18	13	[	[	X
fnp-2671	18	14	9	9	NUM
fnp-2671	18	15	]	]	SYM
fnp-2671	18	16	7	7	NUM
fnp-2671	18	17	.	.	PUNCT
fnp-2671	19	1	‘	'	PUNCT
fnp-2671	19	2	synaptic	synaptic	ADJ
fnp-2671	19	3	cooption	cooption	NOUN
fnp-2671	19	4	’	'	PUNCT
fnp-2671	19	5	in	in	ADP
fnp-2671	19	6	glial	glial	ADJ
fnp-2671	19	7	and	and	CCONJ
fnp-2671	19	8	metastatic	metastatic	ADJ
fnp-2671	19	9	cns	cns	NOUN
fnp-2671	19	10	tumors	tumor	NOUN
fnp-2671	20	1	[	[	X
fnp-2671	20	2	10	10	NUM
fnp-2671	20	3	-	-	SYM
fnp-2671	20	4	12	12	NUM
fnp-2671	20	5	]	]	SYM
fnp-2671	20	6	8	8	NUM
fnp-2671	20	7	.	.	PUNCT
fnp-2671	21	1	the	the	DET
fnp-2671	21	2	role	role	NOUN
fnp-2671	21	3	of	of	ADP
fnp-2671	21	4	cancer	cancer	NOUN
fnp-2671	21	5	stem(-like	stem(-like	NOUN
fnp-2671	21	6	)	)	PUNCT
fnp-2671	21	7	cells	cell	NOUN
fnp-2671	21	8	in	in	ADP
fnp-2671	21	9	glioblastomas	glioblastoma	NOUN
fnp-2671	21	10	[	[	X
fnp-2671	21	11	13	13	NUM
fnp-2671	21	12	]	]	SYM
fnp-2671	21	13	9	9	NUM
fnp-2671	21	14	.	.	PUNCT
fnp-2671	21	15	personalized	personalize	VERB
fnp-2671	21	16	(	(	PUNCT
fnp-2671	21	17	neo)antigen	neo)antigen	NOUN
fnp-2671	21	18	vaccination	vaccination	NOUN
fnp-2671	21	19	therapy	therapy	NOUN
fnp-2671	21	20	for	for	ADP
fnp-2671	21	21	glioblastoma	glioblastoma	NOUN
fnp-2671	21	22	[	[	X
fnp-2671	21	23	14	14	NUM
fnp-2671	21	24	,	,	PUNCT
fnp-2671	21	25	15	15	NUM
fnp-2671	21	26	]	]	SYM
fnp-2671	21	27	10	10	NUM
fnp-2671	21	28	.	.	PUNCT
fnp-2671	22	1	liquid	liquid	ADJ
fnp-2671	22	2	biopsy	biopsy	NOUN
fnp-2671	22	3	diagnosis	diagnosis	NOUN
fnp-2671	22	4	of	of	ADP
fnp-2671	22	5	gliomas	glioma	NOUN
fnp-2671	22	6	using	use	VERB
fnp-2671	22	7	cerebrospinal	cerebrospinal	ADJ
fnp-2671	22	8	fluid	fluid	NOUN
fnp-2671	22	9	(	(	PUNCT
fnp-2671	22	10	csf	csf	NOUN
fnp-2671	22	11	)	)	PUNCT
fnp-2671	23	1	[	[	X
fnp-2671	23	2	16	16	NUM
fnp-2671	23	3	,	,	PUNCT
fnp-2671	23	4	17	17	NUM
fnp-2671	23	5	]	]	PUNCT
fnp-2671	23	6	  	  	SPACE
fnp-2671	23	7	of	of	ADP
fnp-2671	23	8	note	note	NOUN
fnp-2671	23	9	,	,	PUNCT
fnp-2671	23	10	the	the	DET
fnp-2671	23	11	ranking	ranking	NOUN
fnp-2671	23	12	in	in	ADP
fnp-2671	23	13	this	this	DET
fnp-2671	23	14	list	list	NOUN
fnp-2671	23	15	is	be	AUX
fnp-2671	23	16	not	not	PART
fnp-2671	23	17	based	base	VERB
fnp-2671	23	18	on	on	ADP
fnp-2671	23	19	importance	importance	NOUN
fnp-2671	23	20	of	of	ADP
fnp-2671	23	21	the	the	DET
fnp-2671	23	22	findings	finding	NOUN
fnp-2671	23	23	,	,	PUNCT
fnp-2671	23	24	but	but	CCONJ
fnp-2671	23	25	rather	rather	ADV
fnp-2671	23	26	on	on	ADP
fnp-2671	23	27	an	an	DET
fnp-2671	23	28	attempt	attempt	NOUN
fnp-2671	23	29	to	to	PART
fnp-2671	23	30	create	create	VERB
fnp-2671	23	31	a	a	DET
fnp-2671	23	32	flow	flow	NOUN
fnp-2671	23	33	in	in	ADP
fnp-2671	23	34	this	this	DET
fnp-2671	23	35	review	review	NOUN
fnp-2671	23	36	(	(	PUNCT
fnp-2671	23	37	from	from	ADP
fnp-2671	23	38	information	information	NOUN
fnp-2671	23	39	that	that	PRON
fnp-2671	23	40	may	may	AUX
fnp-2671	23	41	quite	quite	ADV
fnp-2671	23	42	readily	readily	ADV
fnp-2671	23	43	be	be	AUX
fnp-2671	23	44	implemented	implement	VERB
fnp-2671	23	45	in	in	ADP
fnp-2671	23	46	daily	daily	ADJ
fnp-2671	23	47	diagnostic	diagnostic	ADJ
fnp-2671	23	48	practice	practice	NOUN
fnp-2671	23	49	via	via	ADP
fnp-2671	23	50	more	more	ADJ
fnp-2671	23	51	hard	hard	ADJ
fnp-2671	23	52	-	-	PUNCT
fnp-2671	23	53	core	core	NOUN
fnp-2671	23	54	neurobiology	neurobiology	NOUN
fnp-2671	23	55	/	/	SYM
fnp-2671	23	56	neuroscience	neuroscience	NOUN
fnp-2671	23	57	findings	finding	NOUN
fnp-2671	23	58	to	to	ADP
fnp-2671	23	59	some	some	DET
fnp-2671	23	60	future	future	ADJ
fnp-2671	23	61	perspectives	perspective	NOUN
fnp-2671	23	62	)	)	PUNCT
fnp-2671	23	63	.	.	PUNCT
fnp-2671	24	1	also	also	ADV
fnp-2671	24	2	,	,	PUNCT
fnp-2671	24	3	there	there	PRON
fnp-2671	24	4	is	be	VERB
fnp-2671	24	5	a	a	DET
fnp-2671	24	6	bias	bias	NOUN
fnp-2671	24	7	in	in	ADP
fnp-2671	24	8	the	the	DET
fnp-2671	24	9	selection	selection	NOUN
fnp-2671	24	10	of	of	ADP
fnp-2671	24	11	the	the	DET
fnp-2671	24	12	topics	topic	NOUN
fnp-2671	24	13	in	in	ADP
fnp-2671	24	14	this	this	DET
fnp-2671	24	15	list	list	NOUN
fnp-2671	24	16	towards	towards	ADP
fnp-2671	24	17	diffuse	diffuse	ADJ
fnp-2671	24	18	gliomas	glioma	NOUN
fnp-2671	24	19	and	and	CCONJ
fnp-2671	24	20	embryonal	embryonal	ADJ
fnp-2671	24	21	tumors	tumor	NOUN
fnp-2671	24	22	/	/	SYM
fnp-2671	24	23	medulloblastomas	medulloblastoma	NOUN
fnp-2671	24	24	.	.	PUNCT
fnp-2671	25	1	obviously	obviously	ADV
fnp-2671	25	2	,	,	PUNCT
fnp-2671	25	3	other	other	ADJ
fnp-2671	25	4	colleagues	colleague	NOUN
fnp-2671	25	5	might	might	AUX
fnp-2671	25	6	have	have	AUX
fnp-2671	25	7	presented	present	VERB
fnp-2671	25	8	a	a	DET
fnp-2671	25	9	quite	quite	ADV
fnp-2671	25	10	different	different	ADJ
fnp-2671	25	11	list	list	NOUN
fnp-2671	25	12	of	of	ADP
fnp-2671	25	13	‘	'	PUNCT
fnp-2671	25	14	top	top	ADJ
fnp-2671	25	15	10	10	NUM
fnp-2671	25	16	discoveries	discovery	NOUN
fnp-2671	25	17	’	'	PUNCT
fnp-2671	25	18	,	,	PUNCT
fnp-2671	25	19	also	also	ADV
fnp-2671	25	20	because	because	SCONJ
fnp-2671	25	21	many	many	ADJ
fnp-2671	25	22	more	more	ADV
fnp-2671	25	23	very	very	ADV
fnp-2671	25	24	good	good	ADJ
fnp-2671	25	25	and	and	CCONJ
fnp-2671	25	26	interesting	interesting	ADJ
fnp-2671	25	27	papers	paper	NOUN
fnp-2671	25	28	with	with	ADP
fnp-2671	25	29	implications	implication	NOUN
fnp-2671	25	30	for	for	ADP
fnp-2671	25	31	neuro	neuro	NOUN
fnp-2671	25	32	-	-	PUNCT
fnp-2671	25	33	oncological	oncological	ADJ
fnp-2671	25	34	pathology	pathology	NOUN
fnp-2671	25	35	were	be	AUX
fnp-2671	25	36	published	publish	VERB
fnp-2671	25	37	in	in	ADP
fnp-2671	25	38	2019	2019	NUM
fnp-2671	25	39	.	.	PUNCT
fnp-2671	26	1	for	for	ADP
fnp-2671	26	2	example	example	NOUN
fnp-2671	26	3	,	,	PUNCT
fnp-2671	26	4	the	the	DET
fnp-2671	26	5	study	study	NOUN
fnp-2671	26	6	of	of	ADP
fnp-2671	26	7	paramasivam	paramasivam	VERB
fnp-2671	26	8	et	et	PROPN
fnp-2671	26	9	al	al	PROPN
fnp-2671	27	1	[	[	X
fnp-2671	27	2	18	18	NUM
fnp-2671	27	3	]	]	PUNCT
fnp-2671	27	4	,	,	PUNCT
fnp-2671	27	5	providing	provide	VERB
fnp-2671	27	6	novel	novel	ADJ
fnp-2671	27	7	information	information	NOUN
fnp-2671	27	8	on	on	ADP
fnp-2671	27	9	mutational	mutational	ADJ
fnp-2671	27	10	patterns	pattern	NOUN
fnp-2671	27	11	and	and	CCONJ
fnp-2671	27	12	regulatory	regulatory	ADJ
fnp-2671	27	13	networks	network	NOUN
fnp-2671	27	14	of	of	ADP
fnp-2671	27	15	subgroups	subgroup	NOUN
fnp-2671	27	16	of	of	ADP
fnp-2671	27	17	meningiomas	meningioma	NOUN
fnp-2671	27	18	would	would	AUX
fnp-2671	27	19	be	be	AUX
fnp-2671	27	20	a	a	DET
fnp-2671	27	21	good	good	ADJ
fnp-2671	27	22	alternative	alternative	NOUN
fnp-2671	27	23	for	for	ADP
fnp-2671	27	24	a	a	DET
fnp-2671	27	25	topic	topic	NOUN
fnp-2671	27	26	.	.	PUNCT
fnp-2671	28	1	having	having	AUX
fnp-2671	28	2	said	say	VERB
fnp-2671	28	3	that	that	PRON
fnp-2671	28	4	,	,	PUNCT
fnp-2671	28	5	it	it	PRON
fnp-2671	28	6	is	be	AUX
fnp-2671	28	7	hoped	hope	VERB
fnp-2671	28	8	that	that	SCONJ
fnp-2671	28	9	this	this	DET
fnp-2671	28	10	review	review	NOUN
fnp-2671	28	11	not	not	PART
fnp-2671	28	12	only	only	ADV
fnp-2671	28	13	provides	provide	VERB
fnp-2671	28	14	easily	easily	ADV
fnp-2671	28	15	digestible	digestible	ADJ
fnp-2671	28	16	information	information	NOUN
fnp-2671	28	17	on	on	ADP
fnp-2671	28	18	the	the	DET
fnp-2671	28	19	top	top	ADJ
fnp-2671	28	20	10	10	NUM
fnp-2671	28	21	discoveries	discovery	NOUN
fnp-2671	28	22	in	in	ADP
fnp-2671	28	23	neuro	neuro	NOUN
fnp-2671	28	24	-	-	PUNCT
fnp-2671	28	25	oncological	oncological	ADJ
fnp-2671	28	26	pathology	pathology	NOUN
fnp-2671	28	27	as	as	SCONJ
fnp-2671	28	28	selected	select	VERB
fnp-2671	28	29	by	by	ADP
fnp-2671	28	30	this	this	DET
fnp-2671	28	31	author	author	NOUN
fnp-2671	28	32	,	,	PUNCT
fnp-2671	28	33	but	but	CCONJ
fnp-2671	28	34	will	will	AUX
fnp-2671	28	35	also	also	ADV
fnp-2671	28	36	be	be	AUX
fnp-2671	28	37	used	use	VERB
fnp-2671	28	38	as	as	ADP
fnp-2671	28	39	a	a	DET
fnp-2671	28	40	stepping	stepping	ADJ
fnp-2671	28	41	stone	stone	NOUN
fnp-2671	28	42	to	to	PART
fnp-2671	28	43	appreciate	appreciate	VERB
fnp-2671	28	44	the	the	DET
fnp-2671	28	45	much	much	ADV
fnp-2671	28	46	more	more	ADV
fnp-2671	28	47	detailed	detailed	ADJ
fnp-2671	28	48	information	information	NOUN
fnp-2671	28	49	in	in	ADP
fnp-2671	28	50	the	the	DET
fnp-2671	28	51	original	original	ADJ
fnp-2671	28	52	papers	paper	NOUN
fnp-2671	28	53	that	that	PRON
fnp-2671	28	54	were	be	AUX
fnp-2671	28	55	used	use	VERB
fnp-2671	28	56	as	as	ADP
fnp-2671	28	57	building	build	VERB
fnp-2671	28	58	blocks	block	NOUN
fnp-2671	28	59	for	for	ADP
fnp-2671	28	60	this	this	DET
fnp-2671	28	61	review	review	NOUN
fnp-2671	28	62	.	.	PUNCT
fnp-2671	29	1	topic	topic	NOUN
fnp-2671	29	2	1	1	NUM
fnp-2671	29	3	.	.	PUNCT
fnp-2671	29	4	lack	lack	NOUN
fnp-2671	29	5	of	of	ADP
fnp-2671	29	6	h3k27me3	h3k27me3	PROPN
fnp-2671	29	7	staining	stain	VERB
fnp-2671	29	8	is	be	AUX
fnp-2671	29	9	a	a	DET
fnp-2671	29	10	promising	promising	ADJ
fnp-2671	29	11	surrogate	surrogate	ADJ
fnp-2671	29	12	marker	marker	NOUN
fnp-2671	29	13	for	for	ADP
fnp-2671	29	14	oligodendrogliomas	oligodendroglioma	NOUN
fnp-2671	29	15	[	[	X
fnp-2671	29	16	1	1	NUM
fnp-2671	29	17	]	]	PUNCT
fnp-2671	29	18	unequivocal	unequivocal	ADJ
fnp-2671	29	19	histological	histological	ADJ
fnp-2671	29	20	recognition	recognition	NOUN
fnp-2671	29	21	of	of	ADP
fnp-2671	29	22	(	(	PUNCT
fnp-2671	29	23	anaplastic	anaplastic	ADJ
fnp-2671	29	24	)	)	PUNCT
fnp-2671	29	25	oligodrogliomas	oligodroglioma	NOUN
fnp-2671	29	26	,	,	PUNCT
fnp-2671	29	27	idh	idh	NOUN
fnp-2671	29	28	-	-	PUNCT
fnp-2671	29	29	mutant	mutant	NOUN
fnp-2671	29	30	&	&	CCONJ
fnp-2671	29	31	1p/19q	1p/19q	NOUN
fnp-2671	29	32	-	-	PUNCT
fnp-2671	29	33	codeleted	codelete	VERB
fnp-2671	29	34	(	(	PUNCT
fnp-2671	29	35	‘	'	PUNCT
fnp-2671	29	36	canonical	canonical	ADJ
fnp-2671	29	37	oligodendrogliomas	oligodendroglioma	NOUN
fnp-2671	29	38	’	'	PUNCT
fnp-2671	29	39	)	)	PUNCT
fnp-2671	29	40	has	have	AUX
fnp-2671	29	41	been	be	AUX
fnp-2671	29	42	hindered	hinder	VERB
fnp-2671	29	43	by	by	ADP
fnp-2671	29	44	the	the	DET
fnp-2671	29	45	lack	lack	NOUN
fnp-2671	29	46	of	of	ADP
fnp-2671	29	47	specific	specific	ADJ
fnp-2671	29	48	immunohistochemical	immunohistochemical	ADJ
fnp-2671	29	49	markers	marker	NOUN
fnp-2671	29	50	for	for	ADP
fnp-2671	29	51	these	these	DET
fnp-2671	29	52	tumors	tumor	NOUN
fnp-2671	30	1	[	[	X
fnp-2671	30	2	19	19	NUM
fnp-2671	30	3	]	]	PUNCT
fnp-2671	30	4	.	.	PUNCT
fnp-2671	31	1	in	in	ADP
fnp-2671	31	2	a	a	DET
fnp-2671	31	3	study	study	NOUN
fnp-2671	31	4	analyzing	analyze	VERB
fnp-2671	31	5	an	an	DET
fnp-2671	31	6	epigenetically	epigenetically	ADV
fnp-2671	31	7	well	well	ADV
fnp-2671	31	8	-	-	PUNCT
fnp-2671	31	9	defined	define	VERB
fnp-2671	31	10	cohort	cohort	NOUN
fnp-2671	31	11	of	of	ADP
fnp-2671	31	12	diffuse	diffuse	ADJ
fnp-2671	31	13	gliomas	glioma	NOUN
fnp-2671	31	14	in	in	ADP
fnp-2671	31	15	adults	adult	NOUN
fnp-2671	31	16	(	(	PUNCT
fnp-2671	31	17	idh	idh	NOUN
fnp-2671	31	18	-	-	PUNCT
fnp-2671	31	19	mutant	mutant	NOUN
fnp-2671	31	20	&	&	CCONJ
fnp-2671	31	21	1p/19q	1p/19q	ADV
fnp-2671	31	22	-	-	PUNCT
fnp-2671	31	23	codeleted	codelete	VERB
fnp-2671	31	24	oligodendrogliomas	oligodendroglioma	NOUN
fnp-2671	31	25	,	,	PUNCT
fnp-2671	31	26	n	n	NOUN
fnp-2671	31	27	=	=	SYM
fnp-2671	31	28	26	26	NUM
fnp-2671	31	29	;	;	PUNCT
fnp-2671	31	30	idh	idh	NOUN
fnp-2671	31	31	-	-	PUNCT
fnp-2671	31	32	mutant	mutant	NOUN
fnp-2671	31	33	astrocytic	astrocytic	ADJ
fnp-2671	31	34	tumors	tumor	NOUN
fnp-2671	31	35	,	,	PUNCT
fnp-2671	31	36	n	n	PROPN
fnp-2671	31	37	=	=	SYM
fnp-2671	31	38	34	34	NUM
fnp-2671	31	39	;	;	PUNCT
fnp-2671	31	40	idh	idh	NOUN
fnp-2671	31	41	-	-	PUNCT
fnp-2671	31	42	wildtype	wildtype	NOUN
fnp-2671	31	43	glioblastomas	glioblastoma	NOUN
fnp-2671	31	44	,	,	PUNCT
fnp-2671	31	45	n	n	PROPN
fnp-2671	31	46	=	=	SYM
fnp-2671	31	47	101	101	NUM
fnp-2671	31	48	)	)	PUNCT
fnp-2671	31	49	,	,	PUNCT
fnp-2671	31	50	filipski	filipski	PROPN
fnp-2671	31	51	et	et	PROPN
fnp-2671	31	52	al	al	PROPN
fnp-2671	31	53	report	report	VERB
fnp-2671	31	54	that	that	SCONJ
fnp-2671	31	55	25	25	NUM
fnp-2671	31	56	out	out	ADP
fnp-2671	31	57	of	of	ADP
fnp-2671	31	58	the	the	DET
fnp-2671	31	59	26	26	NUM
fnp-2671	31	60	oligodendrogliomas	oligodendroglioma	NOUN
fnp-2671	31	61	showed	show	VERB
fnp-2671	31	62	lack	lack	NOUN
fnp-2671	31	63	of	of	ADP
fnp-2671	31	64	nuclear	nuclear	ADJ
fnp-2671	31	65	h3k27me3	h3k27me3	NOUN
fnp-2671	31	66	staining	stain	VERB
fnp-2671	31	67	,	,	PUNCT
fnp-2671	31	68	in	in	ADP
fnp-2671	31	69	the	the	DET
fnp-2671	31	70	remaining	remain	VERB
fnp-2671	31	71	case	case	NOUN
fnp-2671	31	72	h3k27me3	h3k27me3	PROPN
fnp-2671	31	73	staining	stain	VERB
fnp-2671	31	74	was	be	AUX
fnp-2671	31	75	interpreted	interpret	VERB
fnp-2671	31	76	as	as	ADP
fnp-2671	31	77	non	non	ADJ
fnp-2671	31	78	-	-	ADJ
fnp-2671	31	79	conclusive	conclusive	ADJ
fnp-2671	31	80	[	[	X
fnp-2671	31	81	1	1	NUM
fnp-2671	31	82	]	]	PUNCT
fnp-2671	31	83	.	.	PUNCT
fnp-2671	32	1	interestingly	interestingly	ADV
fnp-2671	32	2	,	,	PUNCT
fnp-2671	32	3	in	in	ADP
fnp-2671	32	4	an	an	DET
fnp-2671	32	5	otherwise	otherwise	ADV
fnp-2671	32	6	‘	'	PUNCT
fnp-2671	32	7	nucleonegative	nucleonegative	ADJ
fnp-2671	32	8	’	'	PUNCT
fnp-2671	32	9	oligodendroglioma	oligodendroglioma	NOUN
fnp-2671	32	10	of	of	ADP
fnp-2671	32	11	a	a	DET
fnp-2671	32	12	female	female	ADJ
fnp-2671	32	13	patient	patient	NOUN
fnp-2671	32	14	only	only	ADV
fnp-2671	32	15	dot	dot	NOUN
fnp-2671	32	16	-	-	PUNCT
fnp-2671	32	17	like	like	ADJ
fnp-2671	32	18	nuclear	nuclear	ADJ
fnp-2671	32	19	staining	stain	VERB
fnp-2671	32	20	was	be	AUX
fnp-2671	32	21	seen	see	VERB
fnp-2671	32	22	.	.	PUNCT
fnp-2671	33	1	this	this	DET
fnp-2671	33	2	phenomenon	phenomenon	NOUN
fnp-2671	33	3	has	have	AUX
fnp-2671	33	4	previously	previously	ADV
fnp-2671	33	5	been	be	AUX
fnp-2671	33	6	described	describe	VERB
fnp-2671	33	7	to	to	PART
fnp-2671	33	8	represent	represent	VERB
fnp-2671	33	9	the	the	DET
fnp-2671	33	10	inactivated	inactivated	ADJ
fnp-2671	33	11	x	x	PUNCT
fnp-2671	33	12	chromosome	chromosome	VERB
fnp-2671	33	13	,	,	PUNCT
fnp-2671	33	14	with	with	ADP
fnp-2671	33	15	h3k27me3	h3k27me3	PROPN
fnp-2671	33	16	functioning	function	VERB
fnp-2671	33	17	as	as	ADP
fnp-2671	33	18	a	a	DET
fnp-2671	33	19	transcriptional	transcriptional	ADJ
fnp-2671	33	20	silencing	silence	VERB
fnp-2671	33	21	mechanism	mechanism	NOUN
fnp-2671	33	22	via	via	ADP
fnp-2671	33	23	chromatin	chromatin	NOUN
fnp-2671	33	24	remodeling	remodeling	NOUN
fnp-2671	34	1	[	[	X
fnp-2671	34	2	20	20	NUM
fnp-2671	34	3	]	]	PUNCT
fnp-2671	34	4	(	(	PUNCT
fnp-2671	34	5	fig	fig	NOUN
fnp-2671	34	6	.	.	PUNCT
fnp-2671	34	7	1	1	NUM
fnp-2671	34	8	)	)	PUNCT
fnp-2671	34	9	.	.	PUNCT
fnp-2671	35	1	the	the	DET
fnp-2671	35	2	vast	vast	ADJ
fnp-2671	35	3	majority	majority	NOUN
fnp-2671	35	4	of	of	ADP
fnp-2671	35	5	idh	idh	NOUN
fnp-2671	35	6	-	-	PUNCT
fnp-2671	35	7	mutant	mutant	NOUN
fnp-2671	35	8	and	and	CCONJ
fnp-2671	35	9	idh	idh	NOUN
fnp-2671	35	10	-	-	PUNCT
fnp-2671	35	11	wildtype	wildtype	NOUN
fnp-2671	35	12	astrocytic	astrocytic	ADJ
fnp-2671	35	13	tumors	tumor	NOUN
fnp-2671	35	14	showed	show	VERB
fnp-2671	35	15	clear	clear	ADJ
fnp-2671	35	16	nuclear	nuclear	ADJ
fnp-2671	35	17	h3k27me3	h3k27me3	PROPN
fnp-2671	35	18	staining	stain	VERB
fnp-2671	35	19	.	.	PUNCT
fnp-2671	36	1	based	base	VERB
fnp-2671	36	2	on	on	ADP
fnp-2671	36	3	these	these	DET
fnp-2671	36	4	findings	finding	NOUN
fnp-2671	36	5	in	in	ADP
fnp-2671	36	6	combination	combination	NOUN
fnp-2671	36	7	with	with	ADP
fnp-2671	36	8	the	the	DET
fnp-2671	36	9	results	result	NOUN
fnp-2671	36	10	of	of	ADP
fnp-2671	36	11	immunohistochemistry	immunohistochemistry	NOUN
fnp-2671	36	12	for	for	ADP
fnp-2671	36	13	atrx	atrx	PROPN
fnp-2671	36	14	,	,	PUNCT
fnp-2671	36	15	idh1r132h	idh1r132h	NOUN
fnp-2671	36	16	and	and	CCONJ
fnp-2671	36	17	h3k27	h3k27	NOUN
fnp-2671	36	18	m	m	PROPN
fnp-2671	36	19	,	,	PUNCT
fnp-2671	36	20	filipski	filipski	PROPN
fnp-2671	36	21	et	et	PROPN
fnp-2671	36	22	al	al	PROPN
fnp-2671	36	23	report	report	VERB
fnp-2671	36	24	that	that	SCONJ
fnp-2671	36	25	in	in	ADP
fnp-2671	36	26	their	their	PRON
fnp-2671	36	27	cohort	cohort	NOUN
fnp-2671	36	28	of	of	ADP
fnp-2671	36	29	h3k27	h3k27	NOUN
fnp-2671	36	30	-	-	ADJ
fnp-2671	36	31	wildtype	wildtype	NOUN
fnp-2671	36	32	diffuse	diffuse	NOUN
fnp-2671	36	33	gliomas	glioma	VERB
fnp-2671	36	34	the	the	DET
fnp-2671	36	35	tumors	tumor	NOUN
fnp-2671	36	36	showing	show	VERB
fnp-2671	36	37	lack	lack	NOUN
fnp-2671	36	38	of	of	ADP
fnp-2671	36	39	nuclear	nuclear	ADJ
fnp-2671	36	40	h3k27me3	h3k27me3	NOUN
fnp-2671	36	41	staining	stain	VERB
fnp-2671	36	42	,	,	PUNCT
fnp-2671	36	43	retention	retention	NOUN
fnp-2671	36	44	or	or	CCONJ
fnp-2671	36	45	non	non	ADJ
fnp-2671	36	46	-	-	ADJ
fnp-2671	36	47	conclusive	conclusive	ADJ
fnp-2671	36	48	nuclear	nuclear	ADJ
fnp-2671	36	49	atrx	atrx	NOUN
fnp-2671	36	50	staining	staining	NOUN
fnp-2671	36	51	,	,	PUNCT
fnp-2671	36	52	and	and	CCONJ
fnp-2671	36	53	idh1r132h	idh1r132h	NUM
fnp-2671	36	54	mutation	mutation	NOUN
fnp-2671	36	55	are	be	AUX
fnp-2671	36	56	oligodendroglioma	oligodendroglioma	ADJ
fnp-2671	36	57	,	,	PUNCT
fnp-2671	36	58	idh	idh	NOUN
fnp-2671	36	59	-	-	PUNCT
fnp-2671	36	60	mutant	mutant	NOUN
fnp-2671	36	61	&	&	CCONJ
fnp-2671	36	62	1p/19q	1p/19q	NOUN
fnp-2671	36	63	codeleted	codelete	VERB
fnp-2671	36	64	with	with	ADP
fnp-2671	36	65	a	a	DET
fnp-2671	36	66	predicted	predict	VERB
fnp-2671	36	67	probability	probability	NOUN
fnp-2671	36	68	of	of	ADP
fnp-2671	36	69	0.9678	0.9678	NUM
fnp-2671	36	70	.	.	PUNCT
fnp-2671	37	1	ideally	ideally	ADV
fnp-2671	37	2	,	,	PUNCT
fnp-2671	37	3	in	in	ADP
fnp-2671	37	4	case	case	NOUN
fnp-2671	37	5	of	of	ADP
fnp-2671	37	6	h3k27me3and	h3k27me3and	ADJ
fnp-2671	37	7	h3k27m	h3k27m	NOUN
fnp-2671	37	8	-	-	ADJ
fnp-2671	37	9	nucleonegative	nucleonegative	ADJ
fnp-2671	37	10	diffuse	diffuse	NOUN
fnp-2671	37	11	gliomas	glioma	NOUN
fnp-2671	37	12	that	that	SCONJ
fnp-2671	37	13	in	in	ADP
fnp-2671	37	14	addition	addition	NOUN
fnp-2671	37	15	show	show	NOUN
fnp-2671	37	16	retained	retain	VERB
fnp-2671	37	17	or	or	CCONJ
fnp-2671	37	18	non	non	ADJ
fnp-2671	37	19	-	-	ADJ
fnp-2671	37	20	conclusive	conclusive	ADJ
fnp-2671	37	21	atrx	atrx	NOUN
fnp-2671	37	22	staining	staining	NOUN
fnp-2671	37	23	but	but	CCONJ
fnp-2671	37	24	no	no	DET
fnp-2671	37	25	idh1r132h	idh1r132h	ADJ
fnp-2671	37	26	-	-	ADJ
fnp-2671	37	27	mutant	mutant	ADJ
fnp-2671	37	28	protein	protein	NOUN
fnp-2671	37	29	staining	stain	VERB
fnp-2671	37	30	,	,	PUNCT
fnp-2671	37	31	sequencing	sequence	VERB
fnp-2671	37	32	analysis	analysis	NOUN
fnp-2671	37	33	is	be	AUX
fnp-2671	37	34	performed	perform	VERB
fnp-2671	37	35	to	to	PART
fnp-2671	37	36	demonstrate	demonstrate	VERB
fnp-2671	37	37	presence	presence	NOUN
fnp-2671	37	38	/	/	SYM
fnp-2671	37	39	absence	absence	NOUN
fnp-2671	37	40	of	of	ADP
fnp-2671	37	41	an	an	DET
fnp-2671	37	42	idh1	idh1	NOUN
fnp-2671	37	43	or	or	CCONJ
fnp-2671	37	44	idh2	idh2	PROPN
fnp-2671	37	45	mutation	mutation	NOUN
fnp-2671	37	46	.	.	PUNCT
fnp-2671	38	1	obviously	obviously	ADV
fnp-2671	38	2	,	,	PUNCT
fnp-2671	38	3	the	the	DET
fnp-2671	38	4	results	result	NOUN
fnp-2671	38	5	of	of	ADP
fnp-2671	38	6	immunohistochemistry	immunohistochemistry	NOUN
fnp-2671	38	7	should	should	AUX
fnp-2671	38	8	be	be	AUX
fnp-2671	38	9	interpreted	interpret	VERB
fnp-2671	38	10	with	with	ADP
fnp-2671	38	11	caution	caution	NOUN
fnp-2671	38	12	in	in	ADP
fnp-2671	38	13	especially	especially	ADV
fnp-2671	38	14	biopsies	biopsy	NOUN
fnp-2671	38	15	that	that	PRON
fnp-2671	38	16	are	be	AUX
fnp-2671	38	17	small	small	ADJ
fnp-2671	38	18	and/or	and/or	CCONJ
fnp-2671	38	19	only	only	ADV
fnp-2671	38	20	show	show	VERB
fnp-2671	38	21	low	low	ADJ
fnp-2671	38	22	tumor	tumor	NOUN
fnp-2671	38	23	cell	cell	NOUN
fnp-2671	38	24	percentage	percentage	NOUN
fnp-2671	38	25	.	.	PUNCT
fnp-2671	39	1	the	the	DET
fnp-2671	39	2	use	use	NOUN
fnp-2671	39	3	of	of	ADP
fnp-2671	39	4	an	an	DET
fnp-2671	39	5	antibody	antibody	NOUN
fnp-2671	39	6	panel	panel	NOUN
fnp-2671	39	7	including	include	VERB
fnp-2671	39	8	h3k27me3	h3k27me3	PROPN
fnp-2671	39	9	,	,	PUNCT
fnp-2671	39	10	h3k27	h3k27	NOUN
fnp-2671	39	11	m	m	NOUN
fnp-2671	39	12	mutant	mutant	ADJ
fnp-2671	39	13	protein	protein	NOUN
fnp-2671	39	14	,	,	PUNCT
fnp-2671	39	15	atrx	atrx	ADJ
fnp-2671	39	16	,	,	PUNCT
fnp-2671	39	17	and	and	CCONJ
fnp-2671	39	18	idh1r132h	idh1r132h	NOUN
fnp-2671	39	19	may	may	AUX
fnp-2671	39	20	thus	thus	ADV
fnp-2671	39	21	greatly	greatly	ADV
fnp-2671	39	22	facilitate	facilitate	VERB
fnp-2671	39	23	recognition	recognition	NOUN
fnp-2671	39	24	(	(	PUNCT
fnp-2671	39	25	anaplastic	anaplastic	ADJ
fnp-2671	39	26	)	)	PUNCT
fnp-2671	39	27	oligodendrogliomas	oligodendroglioma	NOUN
fnp-2671	39	28	,	,	PUNCT
fnp-2671	39	29	idh	idh	NOUN
fnp-2671	39	30	-	-	PUNCT
fnp-2671	39	31	mutant	mutant	NOUN
fnp-2671	39	32	&	&	CCONJ
fnp-2671	39	33	1p/19q	1p/19q	NOUN
fnp-2671	39	34	-	-	PUNCT
fnp-2671	39	35	codeleted	codelete	VERB
fnp-2671	39	36	,	,	PUNCT
fnp-2671	39	37	especially	especially	ADV
fnp-2671	39	38	so	so	ADV
fnp-2671	39	39	in	in	ADP
fnp-2671	39	40	a	a	DET
fnp-2671	39	41	situation	situation	NOUN
fnp-2671	39	42	where	where	SCONJ
fnp-2671	39	43	molecular	molecular	ADJ
fnp-2671	39	44	testing	testing	NOUN
fnp-2671	39	45	is	be	AUX
fnp-2671	39	46	not	not	PART
fnp-2671	39	47	readily	readily	ADV
fnp-2671	39	48	available	available	ADJ
fnp-2671	39	49	/	/	SYM
fnp-2671	39	50	possible	possible	ADJ
fnp-2671	39	51	.	.	PUNCT
fnp-2671	40	1	the	the	DET
fnp-2671	40	2	pathobiology	pathobiology	NOUN
fnp-2671	40	3	underlying	underlie	VERB
fnp-2671	40	4	the	the	DET
fnp-2671	40	5	global	global	ADJ
fnp-2671	40	6	lack	lack	NOUN
fnp-2671	40	7	of	of	ADP
fnp-2671	40	8	h3k27me3	h3k27me3	PROPN
fnp-2671	40	9	in	in	ADP
fnp-2671	40	10	tumor	tumor	NOUN
fnp-2671	40	11	cell	cell	NOUN
fnp-2671	40	12	nuclei	nucleus	NOUN
fnp-2671	40	13	and	and	CCONJ
fnp-2671	40	14	1p/19q	1p/19q	NOUN
fnp-2671	40	15	codeletion	codeletion	NOUN
fnp-2671	40	16	needs	need	VERB
fnp-2671	40	17	further	further	ADJ
fnp-2671	40	18	elucidation	elucidation	NOUN
fnp-2671	40	19	.	.	PUNCT
fnp-2671	41	1	of	of	ADP
fnp-2671	41	2	note	note	NOUN
fnp-2671	41	3	,	,	PUNCT
fnp-2671	41	4	while	while	SCONJ
fnp-2671	41	5	in	in	ADP
fnp-2671	41	6	diffuse	diffuse	ADJ
fnp-2671	41	7	gliomas	glioma	NOUN
fnp-2671	41	8	in	in	ADP
fnp-2671	41	9	adults	adult	NOUN
fnp-2671	41	10	lack	lack	NOUN
fnp-2671	41	11	of	of	ADP
fnp-2671	41	12	h3k27me3	h3k27me3	PROPN
fnp-2671	41	13	staining	stain	VERB
fnp-2671	41	14	may	may	AUX
fnp-2671	41	15	thus	thus	ADV
fnp-2671	41	16	indicate	indicate	VERB
fnp-2671	41	17	canonical	canonical	ADJ
fnp-2671	41	18	oligodendroglioma	oligodendroglioma	NOUN
fnp-2671	41	19	with	with	ADP
fnp-2671	41	20	a	a	DET
fnp-2671	41	21	relatively	relatively	ADV
fnp-2671	41	22	favorable	favorable	ADJ
fnp-2671	41	23	prognosis	prognosis	NOUN
fnp-2671	41	24	,	,	PUNCT
fnp-2671	41	25	in	in	ADP
fnp-2671	41	26	several	several	ADJ
fnp-2671	41	27	other	other	ADJ
fnp-2671	41	28	tumors	tumor	NOUN
fnp-2671	41	29	of	of	ADP
fnp-2671	41	30	the	the	DET
fnp-2671	41	31	(	(	PUNCT
fnp-2671	41	32	central	central	ADJ
fnp-2671	41	33	)	)	PUNCT
fnp-2671	41	34	nervous	nervous	ADJ
fnp-2671	41	35	system	system	NOUN
fnp-2671	41	36	(	(	PUNCT
fnp-2671	41	37	e.g.	e.g.	ADV
fnp-2671	41	38	posterior	posterior	ADJ
fnp-2671	41	39	fossa	fossa	ADJ
fnp-2671	41	40	ependymomas	ependymoma	NOUN
fnp-2671	41	41	,	,	PUNCT
fnp-2671	41	42	malignant	malignant	ADJ
fnp-2671	41	43	peripheral	peripheral	ADJ
fnp-2671	41	44	nerve	nerve	NOUN
fnp-2671	41	45	sheath	sheath	NOUN
fnp-2671	41	46	tumors	tumor	NOUN
fnp-2671	41	47	,	,	PUNCT
fnp-2671	41	48	meningiomas	meningioma	NOUN
fnp-2671	41	49	)	)	PUNCT
fnp-2671	41	50	such	such	DET
fnp-2671	41	51	a	a	DET
fnp-2671	41	52	lack	lack	NOUN
fnp-2671	41	53	of	of	ADP
fnp-2671	41	54	nuclear	nuclear	ADJ
fnp-2671	41	55	staining	staining	NOUN
fnp-2671	41	56	is	be	AUX
fnp-2671	41	57	associated	associate	VERB
fnp-2671	41	58	with	with	ADP
fnp-2671	41	59	worse	bad	ADJ
fnp-2671	41	60	prognosis	prognosis	NOUN
fnp-2671	41	61	[	[	X
fnp-2671	41	62	21	21	NUM
fnp-2671	41	63	-	-	SYM
fnp-2671	41	64	23	23	NUM
fnp-2671	41	65	]	]	PUNCT
fnp-2671	41	66	.	.	PUNCT
fnp-2671	42	1	fig	fig	NOUN
fnp-2671	42	2	.	.	PUNCT
fnp-2671	43	1	1	1	X
fnp-2671	43	2	.	.	X
fnp-2671	44	1	loss	loss	NOUN
fnp-2671	44	2	of	of	ADP
fnp-2671	44	3	nuclear	nuclear	ADJ
fnp-2671	44	4	h3k27me3	h3k27me3	PROPN
fnp-2671	44	5	immunohistochemical	immunohistochemical	ADJ
fnp-2671	44	6	staining	staining	NOUN
fnp-2671	44	7	;	;	PUNCT
fnp-2671	44	8	a	a	DET
fnp-2671	44	9	surrogate	surrogate	ADJ
fnp-2671	44	10	marker	marker	NOUN
fnp-2671	44	11	for	for	ADP
fnp-2671	44	12	oligodendroglioma	oligodendroglioma	ADJ
fnp-2671	44	13	,	,	PUNCT
fnp-2671	44	14	idh	idh	NOUN
fnp-2671	44	15	-	-	PUNCT
fnp-2671	44	16	mutant	mutant	NOUN
fnp-2671	44	17	and	and	CCONJ
fnp-2671	44	18	1p/19q	1p/19q	NOUN
fnp-2671	44	19	-	-	PUNCT
fnp-2671	44	20	codeleted	codelete	VERB
fnp-2671	44	21	.	.	PUNCT
fnp-2671	45	1	in	in	ADP
fnp-2671	45	2	the	the	DET
fnp-2671	45	3	past	past	NOUN
fnp-2671	45	4	,	,	PUNCT
fnp-2671	45	5	the	the	DET
fnp-2671	45	6	diagnosis	diagnosis	NOUN
fnp-2671	45	7	oligodendroglioma	oligodendroglioma	NOUN
fnp-2671	45	8	was	be	AUX
fnp-2671	45	9	mainly	mainly	ADV
fnp-2671	45	10	based	base	VERB
fnp-2671	45	11	on	on	ADP
fnp-2671	45	12	histology	histology	NOUN
fnp-2671	45	13	in	in	ADP
fnp-2671	45	14	hematoxylin	hematoxylin	PROPN
fnp-2671	45	15	and	and	CCONJ
fnp-2671	45	16	eosin	eosin	PROPN
fnp-2671	45	17	(	(	PUNCT
fnp-2671	45	18	h&e	h&e	PROPN
fnp-2671	45	19	)	)	PUNCT
fnp-2671	45	20	stained	stain	VERB
fnp-2671	45	21	sections	section	NOUN
fnp-2671	45	22	,	,	PUNCT
fnp-2671	45	23	the	the	DET
fnp-2671	45	24	‘	'	PUNCT
fnp-2671	45	25	fried	fried	ADJ
fnp-2671	45	26	egg	egg	NOUN
fnp-2671	45	27	’	'	PUNCT
fnp-2671	45	28	phenotype	phenotype	NOUN
fnp-2671	45	29	of	of	ADP
fnp-2671	45	30	the	the	DET
fnp-2671	45	31	tumor	tumor	NOUN
fnp-2671	45	32	cells	cell	NOUN
fnp-2671	45	33	being	be	AUX
fnp-2671	45	34	an	an	DET
fnp-2671	45	35	important	important	ADJ
fnp-2671	45	36	clue	clue	NOUN
fnp-2671	45	37	for	for	ADP
fnp-2671	45	38	this	this	DET
fnp-2671	45	39	diagnosis	diagnosis	NOUN
fnp-2671	45	40	(	(	PUNCT
fnp-2671	45	41	a	a	NOUN
fnp-2671	45	42	)	)	PUNCT
fnp-2671	45	43	;	;	PUNCT
fnp-2671	45	44	nowadays	nowadays	ADV
fnp-2671	45	45	,	,	PUNCT
fnp-2671	45	46	demonstration	demonstration	NOUN
fnp-2671	45	47	of	of	ADP
fnp-2671	45	48	idh	idh	NOUN
fnp-2671	45	49	-	-	PUNCT
fnp-2671	45	50	mutant	mutant	NOUN
fnp-2671	45	51	status	status	NOUN
fnp-2671	45	52	and	and	CCONJ
fnp-2671	45	53	(	(	PUNCT
fnp-2671	45	54	complete	complete	ADJ
fnp-2671	45	55	)	)	PUNCT
fnp-2671	46	1	1p/19q	1p/19q	NOUN
fnp-2671	46	2	codeletion	codeletion	NOUN
fnp-2671	46	3	is	be	AUX
fnp-2671	46	4	required	require	VERB
fnp-2671	46	5	for	for	ADP
fnp-2671	46	6	the	the	DET
fnp-2671	46	7	diagnosis	diagnosis	NOUN
fnp-2671	46	8	of	of	ADP
fnp-2671	46	9	‘	'	PUNCT
fnp-2671	46	10	canonical	canonical	ADJ
fnp-2671	46	11	’	'	PUNCT
fnp-2671	46	12	oligodendroglioma	oligodendroglioma	NOUN
fnp-2671	46	13	(	(	PUNCT
fnp-2671	46	14	b	b	NOUN
fnp-2671	46	15	;	;	PUNCT
fnp-2671	46	16	result	result	NOUN
fnp-2671	46	17	of	of	ADP
fnp-2671	46	18	methylome	methylome	ADJ
fnp-2671	46	19	analysis	analysis	NOUN
fnp-2671	46	20	showing	show	VERB
fnp-2671	46	21	(	(	PUNCT
fnp-2671	46	22	with	with	ADP
fnp-2671	46	23	almost	almost	ADV
fnp-2671	46	24	perfect	perfect	ADJ
fnp-2671	46	25	calibrated	calibrate	VERB
fnp-2671	46	26	score	score	NOUN
fnp-2671	46	27	of	of	ADP
fnp-2671	46	28	0.99	0.99	NUM
fnp-2671	46	29	)	)	PUNCT
fnp-2671	46	30	suggested	suggest	VERB
fnp-2671	46	31	diagnosis	diagnosis	NOUN
fnp-2671	46	32	of	of	ADP
fnp-2671	46	33	oligodendroglioma	oligodendroglioma	ADJ
fnp-2671	46	34	,	,	PUNCT
fnp-2671	46	35	idh	idh	NOUN
fnp-2671	46	36	-	-	PUNCT
fnp-2671	46	37	mutant	mutant	NOUN
fnp-2671	46	38	and	and	CCONJ
fnp-2671	46	39	1p/19q	1p/19q	NOUN
fnp-2671	46	40	-	-	PUNCT
fnp-2671	46	41	codeleted	codelete	VERB
fnp-2671	46	42	,	,	PUNCT
fnp-2671	46	43	as	as	ADV
fnp-2671	46	44	well	well	ADV
fnp-2671	46	45	as	as	ADP
fnp-2671	46	46	copy	copy	VERB
fnp-2671	46	47	number	number	NOUN
fnp-2671	46	48	profile	profile	NOUN
fnp-2671	46	49	based	base	VERB
fnp-2671	46	50	on	on	ADP
fnp-2671	46	51	methylome	methylome	ADJ
fnp-2671	46	52	analysis	analysis	NOUN
fnp-2671	46	53	with	with	ADP
fnp-2671	46	54	loss	loss	NOUN
fnp-2671	46	55	of	of	ADP
fnp-2671	46	56	chromosome	chromosome	NOUN
fnp-2671	46	57	arms	arm	NOUN
fnp-2671	46	58	1p	1p	NUM
fnp-2671	46	59	and	and	CCONJ
fnp-2671	46	60	19q	19q	NUM
fnp-2671	46	61	,	,	PUNCT
fnp-2671	46	62	and	and	CCONJ
fnp-2671	46	63	hypermethylated	hypermethylate	VERB
fnp-2671	46	64	status	status	NOUN
fnp-2671	46	65	of	of	ADP
fnp-2671	46	66	mgmt	mgmt	PROPN
fnp-2671	46	67	promoter	promoter	NOUN
fnp-2671	46	68	)	)	PUNCT
fnp-2671	46	69	;	;	PUNCT
fnp-2671	46	70	filipski	filipski	PROPN
fnp-2671	46	71	et	et	PROPN
fnp-2671	46	72	al	al	PROPN
fnp-2671	46	73	report	report	VERB
fnp-2671	46	74	that	that	SCONJ
fnp-2671	46	75	immunohistochemistry	immunohistochemistry	NOUN
fnp-2671	46	76	can	can	AUX
fnp-2671	46	77	be	be	AUX
fnp-2671	46	78	used	use	VERB
fnp-2671	46	79	to	to	PART
fnp-2671	46	80	recognize	recognize	VERB
fnp-2671	46	81	‘	'	PUNCT
fnp-2671	46	82	canonical	canonical	ADJ
fnp-2671	46	83	’	'	PUNCT
fnp-2671	46	84	oligodendrogliomas	oligodendroglioma	NOUN
fnp-2671	46	85	as	as	ADV
fnp-2671	46	86	well	well	ADV
fnp-2671	46	87	,	,	PUNCT
fnp-2671	46	88	the	the	DET
fnp-2671	46	89	combination	combination	NOUN
fnp-2671	46	90	of	of	ADP
fnp-2671	46	91	lack	lack	NOUN
fnp-2671	46	92	of	of	ADP
fnp-2671	46	93	nuclear	nuclear	ADJ
fnp-2671	46	94	h3k27me3	h3k27me3	PROPN
fnp-2671	46	95	staining	stain	VERB
fnp-2671	46	96	,	,	PUNCT
fnp-2671	46	97	retention	retention	NOUN
fnp-2671	46	98	or	or	CCONJ
fnp-2671	46	99	non	non	ADJ
fnp-2671	46	100	-	-	ADJ
fnp-2671	46	101	conclusive	conclusive	ADJ
fnp-2671	46	102	nuclear	nuclear	ADJ
fnp-2671	46	103	atrx	atrx	NOUN
fnp-2671	46	104	staining	staining	NOUN
fnp-2671	46	105	,	,	PUNCT
fnp-2671	46	106	and	and	CCONJ
fnp-2671	46	107	positive	positive	ADJ
fnp-2671	46	108	staining	staining	NOUN
fnp-2671	46	109	for	for	ADP
fnp-2671	46	110	idh1r132h	idh1r132h	NOUN
fnp-2671	46	111	mutant	mutant	ADJ
fnp-2671	46	112	protein	protein	NOUN
fnp-2671	46	113	in	in	ADP
fnp-2671	46	114	h3k27	h3k27	ADJ
fnp-2671	46	115	-	-	ADJ
fnp-2671	46	116	wildtype	wildtype	NOUN
fnp-2671	46	117	diffuse	diffuse	PROPN
fnp-2671	46	118	gliomas	glioma	NOUN
fnp-2671	46	119	being	be	AUX
fnp-2671	46	120	highly	highly	ADV
fnp-2671	46	121	suggestive	suggestive	ADJ
fnp-2671	46	122	for	for	ADP
fnp-2671	46	123	this	this	DET
fnp-2671	46	124	diagnosis	diagnosis	NOUN
fnp-2671	46	125	(	(	PUNCT
fnp-2671	46	126	c	c	NOUN
fnp-2671	46	127	;	;	PUNCT
fnp-2671	46	128	while	while	SCONJ
fnp-2671	46	129	the	the	DET
fnp-2671	46	130	nuclei	nucleus	NOUN
fnp-2671	46	131	of	of	ADP
fnp-2671	46	132	non	non	ADJ
fnp-2671	46	133	-	-	ADJ
fnp-2671	46	134	neoplastic	neoplastic	ADJ
fnp-2671	46	135	cells	cell	NOUN
fnp-2671	46	136	in	in	ADP
fnp-2671	46	137	the	the	DET
fnp-2671	46	138	microvessel	microvessel	NOUN
fnp-2671	46	139	wall	wall	NOUN
fnp-2671	46	140	show	show	VERB
fnp-2671	46	141	strong	strong	ADJ
fnp-2671	46	142	h3k27me3	h3k27me3	PROPN
fnp-2671	46	143	staining	stain	VERB
fnp-2671	46	144	(	(	PUNCT
fnp-2671	46	145	arrowheads	arrowhead	NOUN
fnp-2671	46	146	)	)	PUNCT
fnp-2671	46	147	,	,	PUNCT
fnp-2671	46	148	the	the	DET
fnp-2671	46	149	tumor	tumor	NOUN
fnp-2671	46	150	cell	cell	NOUN
fnp-2671	46	151	nuclei	nucleus	NOUN
fnp-2671	46	152	(	(	PUNCT
fnp-2671	46	153	arrows	arrow	NOUN
fnp-2671	46	154	)	)	PUNCT
fnp-2671	46	155	are	be	AUX
fnp-2671	46	156	largely	largely	ADV
fnp-2671	46	157	negative	negative	ADJ
fnp-2671	46	158	;	;	PUNCT
fnp-2671	46	159	in	in	ADP
fnp-2671	46	160	this	this	DET
fnp-2671	46	161	female	female	ADJ
fnp-2671	46	162	patient	patient	NOUN
fnp-2671	46	163	,	,	PUNCT
fnp-2671	46	164	the	the	DET
fnp-2671	46	165	remaining	remain	VERB
fnp-2671	46	166	positive	positive	ADJ
fnp-2671	46	167	dots	dot	NOUN
fnp-2671	46	168	in	in	ADP
fnp-2671	46	169	the	the	DET
fnp-2671	46	170	tumor	tumor	NOUN
fnp-2671	46	171	cell	cell	NOUN
fnp-2671	46	172	nuclei	nucleus	NOUN
fnp-2671	46	173	represent	represent	VERB
fnp-2671	46	174	the	the	DET
fnp-2671	46	175	inactivated	inactivated	ADJ
fnp-2671	46	176	x	x	PUNCT
fnp-2671	46	177	chromosome	chromosome	NOUN
fnp-2671	46	178	[	[	X
fnp-2671	46	179	20	20	NUM
fnp-2671	46	180	]	]	NUM
fnp-2671	46	181	)	)	PUNCT
fnp-2671	46	182	.	.	PUNCT
fnp-2671	47	1	topic	topic	NOUN
fnp-2671	47	2	2	2	NUM
fnp-2671	47	3	.	.	PUNCT
fnp-2671	47	4	improved	improve	VERB
fnp-2671	47	5	molecular	molecular	ADJ
fnp-2671	47	6	diagnosis	diagnosis	NOUN
fnp-2671	47	7	of	of	ADP
fnp-2671	47	8	rare	rare	ADJ
fnp-2671	47	9	cns	cns	NOUN
fnp-2671	47	10	tumor	tumor	NOUN
fnp-2671	47	11	types	type	NOUN
fnp-2671	47	12	[	[	X
fnp-2671	47	13	2	2	NUM
fnp-2671	47	14	,	,	PUNCT
fnp-2671	47	15	3	3	NUM
fnp-2671	47	16	]	]	PUNCT
fnp-2671	47	17	only	only	ADV
fnp-2671	47	18	recently	recently	ADV
fnp-2671	47	19	,	,	PUNCT
fnp-2671	47	20	genome	genome	NOUN
fnp-2671	47	21	-	-	PUNCT
fnp-2671	47	22	wide	wide	ADJ
fnp-2671	47	23	dna	dna	PROPN
fnp-2671	47	24	methylation	methylation	NOUN
fnp-2671	47	25	analysis	analysis	NOUN
fnp-2671	47	26	has	have	AUX
fnp-2671	47	27	been	be	AUX
fnp-2671	47	28	introduced	introduce	VERB
fnp-2671	47	29	as	as	ADP
fnp-2671	47	30	a	a	DET
fnp-2671	47	31	very	very	ADV
fnp-2671	47	32	helpful	helpful	ADJ
fnp-2671	47	33	tool	tool	NOUN
fnp-2671	47	34	for	for	ADP
fnp-2671	47	35	improved	improved	ADJ
fnp-2671	47	36	diagnosis	diagnosis	NOUN
fnp-2671	47	37	of	of	ADP
fnp-2671	47	38	cns	cns	NOUN
fnp-2671	47	39	tumor	tumor	NOUN
fnp-2671	47	40	types	type	NOUN
fnp-2671	47	41	and	and	CCONJ
fnp-2671	47	42	subtypes	subtype	NOUN
fnp-2671	47	43	[	[	X
fnp-2671	47	44	24	24	NUM
fnp-2671	47	45	-	-	SYM
fnp-2671	47	46	29	29	NUM
fnp-2671	47	47	]	]	PUNCT
fnp-2671	47	48	.	.	PUNCT
fnp-2671	48	1	in	in	ADP
fnp-2671	48	2	2019	2019	NUM
fnp-2671	48	3	,	,	PUNCT
fnp-2671	48	4	two	two	NUM
fnp-2671	48	5	papers	paper	NOUN
fnp-2671	48	6	were	be	AUX
fnp-2671	48	7	published	publish	VERB
fnp-2671	48	8	by	by	ADP
fnp-2671	48	9	the	the	DET
fnp-2671	48	10	‘	'	PUNCT
fnp-2671	48	11	heidelberg	heidelberg	NOUN
fnp-2671	48	12	team	team	NOUN
fnp-2671	48	13	’	'	PUNCT
fnp-2671	49	1	+	+	NUM
fnp-2671	49	2	coauthors	coauthor	NOUN
fnp-2671	49	3	from	from	ADP
fnp-2671	49	4	other	other	ADJ
fnp-2671	49	5	centers	center	NOUN
fnp-2671	49	6	/	/	SYM
fnp-2671	49	7	countries	country	NOUN
fnp-2671	49	8	demonstrating	demonstrate	VERB
fnp-2671	49	9	the	the	DET
fnp-2671	49	10	power	power	NOUN
fnp-2671	49	11	of	of	ADP
fnp-2671	49	12	methylome	methylome	ADJ
fnp-2671	49	13	analysis	analysis	NOUN
fnp-2671	49	14	.	.	PUNCT
fnp-2671	50	1	sievers	sievers	PROPN
fnp-2671	50	2	et	et	PROPN
fnp-2671	50	3	al	al	PROPN
fnp-2671	51	1	[	[	X
fnp-2671	51	2	2	2	NUM
fnp-2671	51	3	]	]	PUNCT
fnp-2671	51	4	report	report	NOUN
fnp-2671	51	5	the	the	DET
fnp-2671	51	6	results	result	NOUN
fnp-2671	51	7	of	of	ADP
fnp-2671	51	8	in	in	ADP
fnp-2671	51	9	-	-	PUNCT
fnp-2671	51	10	depth	depth	NOUN
fnp-2671	51	11	analysis	analysis	NOUN
fnp-2671	51	12	of	of	ADP
fnp-2671	51	13	30	30	NUM
fnp-2671	51	14	tumors	tumor	NOUN
fnp-2671	51	15	initially	initially	ADV
fnp-2671	51	16	identified	identify	VERB
fnp-2671	51	17	through	through	ADP
fnp-2671	51	18	methylome	methylome	ADJ
fnp-2671	51	19	analysis	analysis	NOUN
fnp-2671	51	20	as	as	ADP
fnp-2671	51	21	a	a	DET
fnp-2671	51	22	separate	separate	ADJ
fnp-2671	51	23	group	group	NOUN
fnp-2671	51	24	in	in	ADP
fnp-2671	51	25	a	a	DET
fnp-2671	51	26	heidelberg	heidelberg	NOUN
fnp-2671	51	27	cohort	cohort	NOUN
fnp-2671	51	28	of	of	ADP
fnp-2671	51	29	>	>	SYM
fnp-2671	51	30	25,000	25,000	NUM
fnp-2671	51	31	tumors	tumor	NOUN
fnp-2671	51	32	.	.	PUNCT
fnp-2671	52	1	most	most	ADJ
fnp-2671	52	2	tumors	tumor	NOUN
fnp-2671	52	3	in	in	ADP
fnp-2671	52	4	this	this	DET
fnp-2671	52	5	group	group	NOUN
fnp-2671	52	6	were	be	AUX
fnp-2671	52	7	histologically	histologically	ADV
fnp-2671	52	8	diagnosed	diagnose	VERB
fnp-2671	52	9	as	as	ADP
fnp-2671	52	10	rosette	rosette	NOUN
fnp-2671	52	11	-	-	PUNCT
fnp-2671	52	12	forming	form	VERB
fnp-2671	52	13	glioneuronal	glioneuronal	ADJ
fnp-2671	52	14	tumor	tumor	NOUN
fnp-2671	52	15	(	(	PUNCT
fnp-2671	52	16	rgnt	rgnt	NOUN
fnp-2671	52	17	)	)	PUNCT
fnp-2671	52	18	,	,	PUNCT
fnp-2671	52	19	and	and	CCONJ
fnp-2671	52	20	all	all	PRON
fnp-2671	52	21	revealed	reveal	VERB
fnp-2671	52	22	fgfr1	fgfr1	NOUN
fnp-2671	52	23	hotspot	hotspot	NOUN
fnp-2671	52	24	mutations	mutation	NOUN
fnp-2671	52	25	,	,	PUNCT
fnp-2671	52	26	with	with	ADP
fnp-2671	52	27	in	in	ADP
fnp-2671	52	28	about	about	ADV
fnp-2671	52	29	two	two	NUM
fnp-2671	52	30	-	-	PUNCT
fnp-2671	52	31	thirds	third	NOUN
fnp-2671	52	32	of	of	ADP
fnp-2671	52	33	the	the	DET
fnp-2671	52	34	cases	case	NOUN
fnp-2671	52	35	co	co	NOUN
fnp-2671	52	36	-	-	NOUN
fnp-2671	52	37	occurrence	occurrence	NOUN
fnp-2671	52	38	of	of	ADP
fnp-2671	52	39	a	a	DET
fnp-2671	52	40	pik3ca	pik3ca	NOUN
fnp-2671	52	41	mutation	mutation	NOUN
fnp-2671	52	42	and	and	CCONJ
fnp-2671	52	43	in	in	ADP
fnp-2671	52	44	one	one	NUM
fnp-2671	52	45	third	third	NOUN
fnp-2671	52	46	of	of	ADP
fnp-2671	52	47	the	the	DET
fnp-2671	52	48	tumors	tumor	NOUN
fnp-2671	52	49	an	an	DET
fnp-2671	52	50	additional	additional	ADJ
fnp-2671	52	51	loss	loss	NOUN
fnp-2671	52	52	-	-	PUNCT
fnp-2671	52	53	of	of	ADP
fnp-2671	52	54	-	-	PUNCT
fnp-2671	52	55	function	function	NOUN
fnp-2671	52	56	mutation	mutation	NOUN
fnp-2671	52	57	in	in	ADP
fnp-2671	52	58	nf1	nf1	NOUN
fnp-2671	52	59	.	.	PUNCT
fnp-2671	53	1	in	in	ADP
fnp-2671	53	2	contrast	contrast	NOUN
fnp-2671	53	3	to	to	ADP
fnp-2671	53	4	most	most	ADJ
fnp-2671	53	5	low	low	ADJ
fnp-2671	53	6	-	-	PUNCT
fnp-2671	53	7	grade	grade	NOUN
fnp-2671	53	8	gliomas	glioma	NOUN
fnp-2671	53	9	,	,	PUNCT
fnp-2671	53	10	rgnts	rgnt	NOUN
fnp-2671	53	11	displayed	display	VERB
fnp-2671	53	12	co	co	NOUN
fnp-2671	53	13	-	-	NOUN
fnp-2671	53	14	occurrence	occurrence	NOUN
fnp-2671	53	15	of	of	ADP
fnp-2671	53	16	two	two	NUM
fnp-2671	53	17	or	or	CCONJ
fnp-2671	53	18	even	even	ADV
fnp-2671	53	19	all	all	DET
fnp-2671	53	20	three	three	NUM
fnp-2671	53	21	of	of	ADP
fnp-2671	53	22	these	these	DET
fnp-2671	53	23	mutations	mutation	NOUN
fnp-2671	53	24	.	.	PUNCT
fnp-2671	54	1	these	these	DET
fnp-2671	54	2	highly	highly	ADV
fnp-2671	54	3	recurrent	recurrent	ADJ
fnp-2671	54	4	combined	combine	VERB
fnp-2671	54	5	genetic	genetic	ADJ
fnp-2671	54	6	alterations	alteration	NOUN
fnp-2671	54	7	affecting	affect	VERB
fnp-2671	54	8	both	both	CCONJ
fnp-2671	54	9	mapk	mapk	NOUN
fnp-2671	54	10	and	and	CCONJ
fnp-2671	54	11	pi3k	pi3k	NOUN
fnp-2671	54	12	signaling	signal	VERB
fnp-2671	54	13	pathways	pathway	NOUN
fnp-2671	54	14	may	may	AUX
fnp-2671	54	15	offer	offer	VERB
fnp-2671	54	16	potential	potential	ADJ
fnp-2671	54	17	therapeutic	therapeutic	ADJ
fnp-2671	54	18	targets	target	NOUN
fnp-2671	54	19	for	for	ADP
fnp-2671	54	20	rgnts	rgnt	NOUN
fnp-2671	54	21	[	[	X
fnp-2671	54	22	2	2	NUM
fnp-2671	54	23	]	]	PUNCT
fnp-2671	54	24	.	.	PUNCT
fnp-2671	55	1	in	in	ADP
fnp-2671	55	2	a	a	DET
fnp-2671	55	3	study	study	NOUN
fnp-2671	55	4	of	of	ADP
fnp-2671	55	5	hou	hou	PROPN
fnp-2671	55	6	et	et	PROPN
fnp-2671	55	7	al	al	PROPN
fnp-2671	55	8	[	[	X
fnp-2671	55	9	3	3	NUM
fnp-2671	55	10	]	]	PUNCT
fnp-2671	55	11	,	,	PUNCT
fnp-2671	55	12	17	17	NUM
fnp-2671	55	13	of	of	ADP
fnp-2671	55	14	the	the	DET
fnp-2671	55	15	28	28	NUM
fnp-2671	55	16	tumors	tumor	NOUN
fnp-2671	55	17	initially	initially	ADV
fnp-2671	55	18	histologically	histologically	ADV
fnp-2671	55	19	diagnosed	diagnose	VERB
fnp-2671	55	20	as	as	ADP
fnp-2671	55	21	papillary	papillary	ADJ
fnp-2671	55	22	glioneuronal	glioneuronal	ADJ
fnp-2671	55	23	tumor	tumor	NOUN
fnp-2671	55	24	(	(	PUNCT
fnp-2671	55	25	pgnt	pgnt	PROPN
fnp-2671	55	26	)	)	PUNCT
fnp-2671	55	27	showed	show	VERB
fnp-2671	55	28	methylation	methylation	NOUN
fnp-2671	55	29	profiles	profile	NOUN
fnp-2671	55	30	typical	typical	ADJ
fnp-2671	55	31	for	for	ADP
fnp-2671	55	32	other	other	ADJ
fnp-2671	55	33	tumor	tumor	NOUN
fnp-2671	55	34	entities	entity	NOUN
fnp-2671	55	35	(	(	PUNCT
fnp-2671	55	36	mostly	mostly	ADV
fnp-2671	55	37	dysembryoplastic	dysembryoplastic	ADJ
fnp-2671	55	38	neuroepithelial	neuroepithelial	ADJ
fnp-2671	55	39	tumor	tumor	NOUN
fnp-2671	55	40	and	and	CCONJ
fnp-2671	55	41	pilocytic	pilocytic	ADJ
fnp-2671	55	42	astrocytoma	astrocytoma	NOUN
fnp-2671	55	43	)	)	PUNCT
fnp-2671	55	44	.	.	PUNCT
fnp-2671	56	1	the	the	DET
fnp-2671	56	2	remaining	remain	VERB
fnp-2671	56	3	11	11	NUM
fnp-2671	56	4	cases	case	NOUN
fnp-2671	56	5	exhibited	exhibit	VERB
fnp-2671	56	6	a	a	DET
fnp-2671	56	7	unique	unique	ADJ
fnp-2671	56	8	profile	profile	NOUN
fnp-2671	56	9	and	and	CCONJ
fnp-2671	56	10	were	be	AUX
fnp-2671	56	11	considered	consider	VERB
fnp-2671	56	12	as	as	ADP
fnp-2671	56	13	a	a	DET
fnp-2671	56	14	distinct	distinct	ADJ
fnp-2671	56	15	pgnt	pgnt	PROPN
fnp-2671	56	16	methylation	methylation	NOUN
fnp-2671	56	17	class	class	NOUN
fnp-2671	56	18	.	.	PUNCT
fnp-2671	57	1	three	three	NUM
fnp-2671	57	2	additional	additional	ADJ
fnp-2671	57	3	tumors	tumor	NOUN
fnp-2671	57	4	in	in	ADP
fnp-2671	57	5	the	the	DET
fnp-2671	57	6	heidelberg	heidelberg	NOUN
fnp-2671	57	7	cohort	cohort	NOUN
fnp-2671	57	8	clustered	cluster	VERB
fnp-2671	57	9	with	with	ADP
fnp-2671	57	10	this	this	DET
fnp-2671	57	11	methylation	methylation	NOUN
fnp-2671	57	12	class	class	NOUN
fnp-2671	57	13	as	as	ADV
fnp-2671	57	14	well	well	ADV
fnp-2671	57	15	but	but	CCONJ
fnp-2671	57	16	were	be	AUX
fnp-2671	57	17	originally	originally	ADV
fnp-2671	57	18	not	not	PART
fnp-2671	57	19	diagnosed	diagnose	VERB
fnp-2671	57	20	as	as	ADP
fnp-2671	57	21	pgnt	pgnt	PROPN
fnp-2671	57	22	.	.	PUNCT
fnp-2671	58	1	in	in	ADP
fnp-2671	58	2	all	all	DET
fnp-2671	58	3	12	12	NUM
fnp-2671	58	4	cases	case	NOUN
fnp-2671	58	5	of	of	ADP
fnp-2671	58	6	this	this	DET
fnp-2671	58	7	methylation	methylation	NOUN
fnp-2671	58	8	class	class	NOUN
fnp-2671	58	9	of	of	ADP
fnp-2671	58	10	which	which	DET
fnp-2671	58	11	material	material	NOUN
fnp-2671	58	12	was	be	AUX
fnp-2671	58	13	available	available	ADJ
fnp-2671	58	14	for	for	ADP
fnp-2671	58	15	further	further	ADJ
fnp-2671	58	16	analysis	analysis	NOUN
fnp-2671	58	17	,	,	PUNCT
fnp-2671	58	18	fusions	fusion	NOUN
fnp-2671	58	19	involving	involve	VERB
fnp-2671	58	20	prkca	prkca	NOUN
fnp-2671	58	21	were	be	AUX
fnp-2671	58	22	identified	identify	VERB
fnp-2671	58	23	(	(	PUNCT
fnp-2671	58	24	slc44a1	slc44a1	PROPN
fnp-2671	58	25	–	–	PUNCT
fnp-2671	58	26	prkca	prkca	ADJ
fnp-2671	58	27	,	,	PUNCT
fnp-2671	58	28	n	n	NOUN
fnp-2671	58	29	=	=	SYM
fnp-2671	58	30	11	11	NUM
fnp-2671	58	31	;	;	PUNCT
fnp-2671	58	32	notch1	notch1	NOUN
fnp-2671	58	33	-	-	PUNCT
fnp-2671	58	34	prkca	prkca	VERB
fnp-2671	58	35	,	,	PUNCT
fnp-2671	58	36	n	n	NOUN
fnp-2671	58	37	=	=	SYM
fnp-2671	58	38	1	1	NUM
fnp-2671	58	39	)	)	PUNCT
fnp-2671	58	40	,	,	PUNCT
fnp-2671	58	41	whereas	whereas	SCONJ
fnp-2671	58	42	such	such	ADJ
fnp-2671	58	43	fusions	fusion	NOUN
fnp-2671	58	44	were	be	AUX
fnp-2671	58	45	not	not	PART
fnp-2671	58	46	found	find	VERB
fnp-2671	58	47	in	in	ADP
fnp-2671	58	48	the	the	DET
fnp-2671	58	49	tumors	tumor	NOUN
fnp-2671	58	50	belonging	belong	VERB
fnp-2671	58	51	to	to	ADP
fnp-2671	58	52	other	other	ADJ
fnp-2671	58	53	methylation	methylation	NOUN
fnp-2671	58	54	classes	class	NOUN
fnp-2671	58	55	.	.	PUNCT
fnp-2671	59	1	both	both	CCONJ
fnp-2671	59	2	the	the	DET
fnp-2671	59	3	study	study	NOUN
fnp-2671	59	4	of	of	ADP
fnp-2671	59	5	sievers	sievers	PROPN
fnp-2671	59	6	et	et	PROPN
fnp-2671	59	7	al	al	PROPN
fnp-2671	59	8	and	and	CCONJ
fnp-2671	59	9	of	of	ADP
fnp-2671	59	10	hou	hou	PROPN
fnp-2671	59	11	et	et	PROPN
fnp-2671	59	12	al	al	PROPN
fnp-2671	59	13	thus	thus	ADV
fnp-2671	59	14	provide	provide	VERB
fnp-2671	59	15	information	information	NOUN
fnp-2671	59	16	on	on	ADP
fnp-2671	59	17	molecular	molecular	ADJ
fnp-2671	59	18	characteristics	characteristic	NOUN
fnp-2671	59	19	that	that	PRON
fnp-2671	59	20	can	can	AUX
fnp-2671	59	21	be	be	AUX
fnp-2671	59	22	used	use	VERB
fnp-2671	59	23	for	for	ADP
fnp-2671	59	24	improved	improved	ADJ
fnp-2671	59	25	recognition	recognition	NOUN
fnp-2671	59	26	of	of	ADP
fnp-2671	59	27	such	such	ADJ
fnp-2671	59	28	rare	rare	ADJ
fnp-2671	59	29	cns	cns	NOUN
fnp-2671	59	30	tumor	tumor	NOUN
fnp-2671	59	31	types	type	NOUN
fnp-2671	59	32	and	and	CCONJ
fnp-2671	59	33	again	again	ADV
fnp-2671	59	34	illustrate	illustrate	VERB
fnp-2671	59	35	the	the	DET
fnp-2671	59	36	power	power	NOUN
fnp-2671	59	37	of	of	ADP
fnp-2671	59	38	methylome	methylome	ADJ
fnp-2671	59	39	analysis	analysis	NOUN
fnp-2671	59	40	in	in	ADP
fnp-2671	59	41	this	this	DET
fnp-2671	59	42	context	context	NOUN
fnp-2671	59	43	.	.	PUNCT
fnp-2671	60	1	topic	topic	NOUN
fnp-2671	60	2	3	3	NUM
fnp-2671	60	3	.	.	PUNCT
fnp-2671	60	4	refined	refine	VERB
fnp-2671	60	5	molecular	molecular	ADJ
fnp-2671	60	6	classification	classification	NOUN
fnp-2671	60	7	of	of	ADP
fnp-2671	60	8	non	non	NOUN
fnp-2671	60	9	-	-	ADJ
fnp-2671	60	10	wnt	wnt	NOUN
fnp-2671	60	11	/	/	SYM
fnp-2671	60	12	non	non	ADJ
fnp-2671	60	13	-	-	ADJ
fnp-2671	60	14	shh	shh	ADJ
fnp-2671	60	15	medulloblastomas	medulloblastoma	NOUN
fnp-2671	61	1	[	[	X
fnp-2671	61	2	4	4	X
fnp-2671	61	3	]	]	X
fnp-2671	61	4	the	the	DET
fnp-2671	61	5	2016	2016	NUM
fnp-2671	61	6	who	who	PRON
fnp-2671	61	7	classification	classification	NOUN
fnp-2671	61	8	of	of	ADP
fnp-2671	61	9	cns	cns	PROPN
fnp-2671	61	10	tumors	tumor	NOUN
fnp-2671	61	11	recognizes	recognize	VERB
fnp-2671	61	12	four	four	NUM
fnp-2671	61	13	molecular	molecular	ADJ
fnp-2671	61	14	variants	variant	NOUN
fnp-2671	61	15	of	of	ADP
fnp-2671	61	16	medulloblastoma	medulloblastoma	NOUN
fnp-2671	61	17	:	:	PUNCT
fnp-2671	61	18	wnt	wnt	NOUN
fnp-2671	61	19	-	-	PUNCT
fnp-2671	61	20	activated	activated	ADJ
fnp-2671	61	21	,	,	PUNCT
fnp-2671	61	22	shh	shh	NOUN
fnp-2671	61	23	-	-	VERB
fnp-2671	61	24	activated	activated	ADJ
fnp-2671	61	25	and	and	CCONJ
fnp-2671	61	26	tp53	tp53	PROPN
fnp-2671	61	27	-	-	PUNCT
fnp-2671	61	28	mutant	mutant	NOUN
fnp-2671	61	29	,	,	PUNCT
fnp-2671	61	30	shh	shh	NOUN
fnp-2671	61	31	-	-	VERB
fnp-2671	61	32	activated	activated	ADJ
fnp-2671	61	33	and	and	CCONJ
fnp-2671	61	34	tp53	tp53	PROPN
fnp-2671	61	35	-	-	PUNCT
fnp-2671	61	36	wildtype	wildtype	NOUN
fnp-2671	61	37	,	,	PUNCT
fnp-2671	61	38	and	and	CCONJ
fnp-2671	61	39	non	non	PROPN
fnp-2671	61	40	-	-	ADJ
fnp-2671	61	41	wnt	wnt	NOUN
fnp-2671	61	42	/	/	SYM
fnp-2671	61	43	non	non	NOUN
fnp-2671	61	44	-	-	NOUN
fnp-2671	61	45	shh	shh	NOUN
fnp-2671	61	46	.	.	PUNCT
fnp-2671	62	1	the	the	DET
fnp-2671	62	2	non	non	PROPN
fnp-2671	62	3	-	-	ADJ
fnp-2671	62	4	wnt	wnt	NOUN
fnp-2671	62	5	/	/	SYM
fnp-2671	62	6	non	non	ADJ
fnp-2671	62	7	-	-	PROPN
fnp-2671	62	8	shh	shh	ADJ
fnp-2671	62	9	subgroup	subgroup	PROPN
fnp-2671	62	10	,	,	PUNCT
fnp-2671	62	11	accounting	account	VERB
fnp-2671	62	12	for	for	ADP
fnp-2671	62	13	about	about	ADV
fnp-2671	62	14	65	65	NUM
fnp-2671	62	15	%	%	NOUN
fnp-2671	62	16	of	of	ADP
fnp-2671	62	17	all	all	DET
fnp-2671	62	18	medulloblastomas	medulloblastoma	NOUN
fnp-2671	62	19	,	,	PUNCT
fnp-2671	62	20	encompasses	encompass	VERB
fnp-2671	62	21	the	the	DET
fnp-2671	62	22	group	group	NOUN
fnp-2671	62	23	3	3	NUM
fnp-2671	62	24	and	and	CCONJ
fnp-2671	62	25	group	group	NOUN
fnp-2671	62	26	4	4	NUM
fnp-2671	62	27	molecular	molecular	ADJ
fnp-2671	62	28	variants	variant	NOUN
fnp-2671	62	29	of	of	ADP
fnp-2671	62	30	medulloblastoma	medulloblastoma	NOUN
fnp-2671	62	31	.	.	PUNCT
fnp-2671	63	1	however	however	ADV
fnp-2671	63	2	,	,	PUNCT
fnp-2671	63	3	these	these	DET
fnp-2671	63	4	groups	group	NOUN
fnp-2671	63	5	have	have	VERB
fnp-2671	63	6	heterogeneous	heterogeneous	ADJ
fnp-2671	63	7	clinical	clinical	ADJ
fnp-2671	63	8	characteristics	characteristic	NOUN
fnp-2671	63	9	and	and	CCONJ
fnp-2671	63	10	survival	survival	NOUN
fnp-2671	63	11	outcomes	outcome	NOUN
fnp-2671	63	12	,	,	PUNCT
fnp-2671	63	13	and	and	CCONJ
fnp-2671	63	14	their	their	PRON
fnp-2671	63	15	biology	biology	NOUN
fnp-2671	63	16	remained	remain	VERB
fnp-2671	63	17	less	less	ADV
fnp-2671	63	18	clear	clear	ADJ
fnp-2671	63	19	.	.	PUNCT
fnp-2671	64	1	studies	study	NOUN
fnp-2671	64	2	published	publish	VERB
fnp-2671	64	3	in	in	ADP
fnp-2671	64	4	2017	2017	NUM
fnp-2671	64	5	suggested	suggest	VERB
fnp-2671	64	6	the	the	DET
fnp-2671	64	7	existence	existence	NOUN
fnp-2671	64	8	of	of	ADP
fnp-2671	64	9	4	4	NUM
fnp-2671	64	10	,	,	PUNCT
fnp-2671	64	11	6	6	NUM
fnp-2671	64	12	or	or	CCONJ
fnp-2671	64	13	8	8	NUM
fnp-2671	64	14	subgroups	subgroup	NOUN
fnp-2671	64	15	within	within	ADP
fnp-2671	64	16	the	the	DET
fnp-2671	64	17	overarching	overarching	ADJ
fnp-2671	64	18	non	non	NOUN
fnp-2671	64	19	-	-	ADJ
fnp-2671	64	20	wnt	wnt	NOUN
fnp-2671	64	21	/	/	SYM
fnp-2671	64	22	non	non	ADJ
fnp-2671	64	23	-	-	ADJ
fnp-2671	64	24	shh	shh	ADJ
fnp-2671	64	25	group	group	NOUN
fnp-2671	65	1	[	[	X
fnp-2671	65	2	30	30	NUM
fnp-2671	65	3	-	-	SYM
fnp-2671	65	4	32	32	NUM
fnp-2671	65	5	]	]	PUNCT
fnp-2671	65	6	.	.	PUNCT
fnp-2671	66	1	in	in	ADP
fnp-2671	66	2	an	an	DET
fnp-2671	66	3	attempt	attempt	NOUN
fnp-2671	66	4	to	to	PART
fnp-2671	66	5	provide	provide	VERB
fnp-2671	66	6	clarity	clarity	NOUN
fnp-2671	66	7	and	and	CCONJ
fnp-2671	66	8	a	a	DET
fnp-2671	66	9	basis	basis	NOUN
fnp-2671	66	10	for	for	ADP
fnp-2671	66	11	further	further	ADJ
fnp-2671	66	12	biological	biological	ADJ
fnp-2671	66	13	studies	study	NOUN
fnp-2671	66	14	,	,	PUNCT
fnp-2671	66	15	sharma	sharma	PROPN
fnp-2671	66	16	et	et	PROPN
fnp-2671	66	17	al	al	PROPN
fnp-2671	66	18	analyzed	analyze	VERB
fnp-2671	66	19	the	the	DET
fnp-2671	66	20	number	number	NOUN
fnp-2671	66	21	and	and	CCONJ
fnp-2671	66	22	nature	nature	NOUN
fnp-2671	66	23	of	of	ADP
fnp-2671	66	24	subtypes	subtype	NOUN
fnp-2671	66	25	that	that	PRON
fnp-2671	66	26	could	could	AUX
fnp-2671	66	27	be	be	AUX
fnp-2671	66	28	identified	identify	VERB
fnp-2671	66	29	in	in	ADP
fnp-2671	66	30	a	a	DET
fnp-2671	66	31	cohort	cohort	NOUN
fnp-2671	66	32	of	of	ADP
fnp-2671	66	33	1501	1501	NUM
fnp-2671	66	34	genomically	genomically	ADV
fnp-2671	66	35	characterized	characterize	VERB
fnp-2671	66	36	non	non	ADJ
fnp-2671	66	37	-	-	ADJ
fnp-2671	66	38	wnt	wnt	NOUN
fnp-2671	66	39	/	/	SYM
fnp-2671	66	40	non	non	ADJ
fnp-2671	66	41	-	-	ADJ
fnp-2671	66	42	shh	shh	ADJ
fnp-2671	66	43	medulloblastomas	medulloblastoma	NOUN
fnp-2671	66	44	[	[	X
fnp-2671	66	45	4	4	NUM
fnp-2671	66	46	]	]	PUNCT
fnp-2671	66	47	.	.	PUNCT
fnp-2671	67	1	in	in	ADP
fnp-2671	67	2	this	this	DET
fnp-2671	67	3	study	study	NOUN
fnp-2671	67	4	,	,	PUNCT
fnp-2671	67	5	rather	rather	ADV
fnp-2671	67	6	than	than	ADP
fnp-2671	67	7	advocating	advocate	VERB
fnp-2671	67	8	one	one	NUM
fnp-2671	67	9	single	single	ADJ
fnp-2671	67	10	analytical	analytical	ADJ
fnp-2671	67	11	approach	approach	NOUN
fnp-2671	67	12	or	or	CCONJ
fnp-2671	67	13	method	method	NOUN
fnp-2671	67	14	,	,	PUNCT
fnp-2671	67	15	multiple	multiple	ADJ
fnp-2671	67	16	class	class	NOUN
fnp-2671	67	17	-	-	PUNCT
fnp-2671	67	18	definition	definition	NOUN
fnp-2671	67	19	approaches	approach	NOUN
fnp-2671	67	20	were	be	AUX
fnp-2671	67	21	used	use	VERB
fnp-2671	67	22	and	and	CCONJ
fnp-2671	67	23	equal	equal	ADJ
fnp-2671	67	24	weight	weight	NOUN
fnp-2671	67	25	was	be	AUX
fnp-2671	67	26	given	give	VERB
fnp-2671	67	27	to	to	ADP
fnp-2671	67	28	each	each	DET
fnp-2671	67	29	analytical	analytical	ADJ
fnp-2671	67	30	technique	technique	NOUN
fnp-2671	67	31	.	.	PUNCT
fnp-2671	68	1	in	in	ADP
fnp-2671	68	2	a	a	DET
fnp-2671	68	3	lower	low	ADJ
fnp-2671	68	4	complexity	complexity	NOUN
fnp-2671	68	5	analysis	analysis	NOUN
fnp-2671	68	6	group	group	NOUN
fnp-2671	68	7	3	3	NUM
fnp-2671	68	8	and	and	CCONJ
fnp-2671	68	9	group	group	NOUN
fnp-2671	68	10	4	4	NUM
fnp-2671	68	11	were	be	AUX
fnp-2671	68	12	identified	identify	VERB
fnp-2671	68	13	again	again	ADV
fnp-2671	68	14	,	,	PUNCT
fnp-2671	68	15	but	but	CCONJ
fnp-2671	68	16	more	more	ADV
fnp-2671	68	17	complex	complex	ADJ
fnp-2671	68	18	analysis	analysis	NOUN
fnp-2671	68	19	strongly	strongly	ADV
fnp-2671	68	20	supported	support	VERB
fnp-2671	68	21	the	the	DET
fnp-2671	68	22	existence	existence	NOUN
fnp-2671	68	23	of	of	ADP
fnp-2671	68	24	eight	eight	NUM
fnp-2671	68	25	robust	robust	ADJ
fnp-2671	68	26	group	group	NOUN
fnp-2671	68	27	3	3	NUM
fnp-2671	68	28	/	/	SYM
fnp-2671	68	29	group	group	NOUN
fnp-2671	68	30	4	4	NUM
fnp-2671	68	31	subtypes	subtype	NOUN
fnp-2671	68	32	(	(	PUNCT
fnp-2671	68	33	i	i	NOUN
fnp-2671	68	34	-	-	PUNCT
fnp-2671	68	35	viii	viii	NOUN
fnp-2671	68	36	)	)	PUNCT
fnp-2671	68	37	.	.	PUNCT
fnp-2671	69	1	these	these	DET
fnp-2671	69	2	subtypes	subtype	NOUN
fnp-2671	69	3	could	could	AUX
fnp-2671	69	4	generally	generally	ADV
fnp-2671	69	5	be	be	AUX
fnp-2671	69	6	recognized	recognize	VERB
fnp-2671	69	7	based	base	VERB
fnp-2671	69	8	on	on	ADP
fnp-2671	69	9	their	their	PRON
fnp-2671	69	10	dna	dna	NOUN
fnp-2671	69	11	-	-	PUNCT
fnp-2671	69	12	methylation	methylation	NOUN
fnp-2671	69	13	profiles	profile	NOUN
fnp-2671	69	14	and	and	CCONJ
fnp-2671	69	15	showed	show	VERB
fnp-2671	69	16	differences	difference	NOUN
fnp-2671	69	17	in	in	ADP
fnp-2671	69	18	enrichment	enrichment	NOUN
fnp-2671	69	19	for	for	ADP
fnp-2671	69	20	specific	specific	ADJ
fnp-2671	69	21	driver	driver	NOUN
fnp-2671	69	22	gene	gene	NOUN
fnp-2671	69	23	alterations	alteration	NOUN
fnp-2671	69	24	,	,	PUNCT
fnp-2671	69	25	cytogenetic	cytogenetic	ADJ
fnp-2671	69	26	events	event	NOUN
fnp-2671	69	27	,	,	PUNCT
fnp-2671	69	28	and	and	CCONJ
fnp-2671	69	29	ages	age	NOUN
fnp-2671	69	30	of	of	ADP
fnp-2671	69	31	incidence	incidence	NOUN
fnp-2671	69	32	with	with	ADP
fnp-2671	69	33	mostly	mostly	ADV
fnp-2671	69	34	unimodal	unimodal	ADJ
fnp-2671	69	35	age	age	NOUN
fnp-2671	69	36	distribution	distribution	NOUN
fnp-2671	69	37	.	.	PUNCT
fnp-2671	70	1	cytogenetic	cytogenetic	ADJ
fnp-2671	70	2	signatures	signature	NOUN
fnp-2671	70	3	,	,	PUNCT
fnp-2671	70	4	chromosomal	chromosomal	ADJ
fnp-2671	70	5	copy	copy	NOUN
fnp-2671	70	6	-	-	PUNCT
fnp-2671	70	7	number	number	NOUN
fnp-2671	70	8	aberrations	aberration	NOUN
fnp-2671	70	9	and	and	CCONJ
fnp-2671	70	10	information	information	NOUN
fnp-2671	70	11	on	on	ADP
fnp-2671	70	12	one	one	NUM
fnp-2671	70	13	gene	gene	NOUN
fnp-2671	70	14	or	or	CCONJ
fnp-2671	70	15	a	a	DET
fnp-2671	70	16	set	set	NOUN
fnp-2671	70	17	of	of	ADP
fnp-2671	70	18	genes	gene	NOUN
fnp-2671	70	19	in	in	ADP
fnp-2671	70	20	isolation	isolation	NOUN
fnp-2671	70	21	were	be	AUX
fnp-2671	70	22	found	find	VERB
fnp-2671	70	23	to	to	PART
fnp-2671	70	24	be	be	AUX
fnp-2671	70	25	insufficient	insufficient	ADJ
fnp-2671	70	26	for	for	ADP
fnp-2671	70	27	recognition	recognition	NOUN
fnp-2671	70	28	of	of	ADP
fnp-2671	70	29	subtypes	subtype	NOUN
fnp-2671	70	30	i	i	NOUN
fnp-2671	70	31	-	-	PUNCT
fnp-2671	70	32	viii	viii	PROPN
fnp-2671	70	33	.	.	PUNCT
fnp-2671	71	1	the	the	DET
fnp-2671	71	2	relevance	relevance	NOUN
fnp-2671	71	3	of	of	ADP
fnp-2671	71	4	these	these	DET
fnp-2671	71	5	subtypes	subtype	NOUN
fnp-2671	71	6	is	be	AUX
fnp-2671	71	7	supported	support	VERB
fnp-2671	71	8	by	by	ADP
fnp-2671	71	9	differences	difference	NOUN
fnp-2671	71	10	in	in	ADP
fnp-2671	71	11	survival	survival	NOUN
fnp-2671	71	12	,	,	PUNCT
fnp-2671	71	13	with	with	ADP
fnp-2671	71	14	e.g.	e.g.	ADV
fnp-2671	71	15	subtype	subtype	NOUN
fnp-2671	71	16	iv	iv	ADP
fnp-2671	71	17	being	be	AUX
fnp-2671	71	18	associated	associate	VERB
fnp-2671	71	19	with	with	ADP
fnp-2671	71	20	low	low	ADJ
fnp-2671	71	21	-	-	PUNCT
fnp-2671	71	22	risk	risk	NOUN
fnp-2671	71	23	clinical	clinical	ADJ
fnp-2671	71	24	behavior	behavior	NOUN
fnp-2671	71	25	,	,	PUNCT
fnp-2671	71	26	and	and	CCONJ
fnp-2671	71	27	with	with	ADP
fnp-2671	71	28	relatively	relatively	ADV
fnp-2671	71	29	frequent	frequent	ADJ
fnp-2671	71	30	late	late	ADJ
fnp-2671	71	31	relapses	relapse	NOUN
fnp-2671	71	32	in	in	ADP
fnp-2671	71	33	patients	patient	NOUN
fnp-2671	71	34	with	with	ADP
fnp-2671	71	35	a	a	DET
fnp-2671	71	36	subtype	subtype	NOUN
fnp-2671	71	37	viii	viii	ADJ
fnp-2671	71	38	medulloblastoma	medulloblastoma	NOUN
fnp-2671	71	39	.	.	PUNCT
fnp-2671	72	1	these	these	DET
fnp-2671	72	2	findings	finding	NOUN
fnp-2671	72	3	can	can	AUX
fnp-2671	72	4	be	be	AUX
fnp-2671	72	5	expected	expect	VERB
fnp-2671	72	6	to	to	PART
fnp-2671	72	7	improve	improve	VERB
fnp-2671	72	8	risk	risk	NOUN
fnp-2671	72	9	stratification	stratification	NOUN
fnp-2671	72	10	,	,	PUNCT
fnp-2671	72	11	therapy	therapy	NOUN
fnp-2671	72	12	and	and	CCONJ
fnp-2671	72	13	thereby	thereby	ADV
fnp-2671	72	14	the	the	DET
fnp-2671	72	15	outcome	outcome	NOUN
fnp-2671	72	16	for	for	ADP
fnp-2671	72	17	patients	patient	NOUN
fnp-2671	72	18	with	with	ADP
fnp-2671	72	19	non	non	NOUN
fnp-2671	72	20	-	-	ADJ
fnp-2671	72	21	wnt	wnt	NOUN
fnp-2671	72	22	/	/	SYM
fnp-2671	72	23	non	non	ADJ
fnp-2671	72	24	-	-	ADJ
fnp-2671	72	25	shh	shh	ADJ
fnp-2671	72	26	medulloblastomas	medulloblastoma	NOUN
fnp-2671	72	27	.	.	PUNCT
fnp-2671	73	1	of	of	ADP
fnp-2671	73	2	note	note	NOUN
fnp-2671	73	3	,	,	PUNCT
fnp-2671	73	4	although	although	SCONJ
fnp-2671	73	5	the	the	DET
fnp-2671	73	6	bimodal	bimodal	NOUN
fnp-2671	73	7	age	age	NOUN
fnp-2671	73	8	distribution	distribution	NOUN
fnp-2671	73	9	that	that	PRON
fnp-2671	73	10	was	be	AUX
fnp-2671	73	11	found	find	VERB
fnp-2671	73	12	for	for	ADP
fnp-2671	73	13	subtypes	subtype	NOUN
fnp-2671	73	14	v	v	VERB
fnp-2671	73	15	and	and	CCONJ
fnp-2671	73	16	vii	vii	PROPN
fnp-2671	73	17	may	may	AUX
fnp-2671	73	18	indicate	indicate	VERB
fnp-2671	73	19	that	that	SCONJ
fnp-2671	73	20	some	some	DET
fnp-2671	73	21	further	further	ADJ
fnp-2671	73	22	refinement	refinement	NOUN
fnp-2671	73	23	of	of	ADP
fnp-2671	73	24	the	the	DET
fnp-2671	73	25	classification	classification	NOUN
fnp-2671	73	26	is	be	AUX
fnp-2671	73	27	still	still	ADV
fnp-2671	73	28	possible	possible	ADJ
fnp-2671	73	29	,	,	PUNCT
fnp-2671	73	30	the	the	DET
fnp-2671	73	31	authors	author	NOUN
fnp-2671	73	32	report	report	VERB
fnp-2671	73	33	that	that	SCONJ
fnp-2671	73	34	they	they	PRON
fnp-2671	73	35	did	do	AUX
fnp-2671	73	36	not	not	PART
fnp-2671	73	37	find	find	VERB
fnp-2671	73	38	strong	strong	ADJ
fnp-2671	73	39	evidence	evidence	NOUN
fnp-2671	73	40	for	for	ADP
fnp-2671	73	41	more	more	ADJ
fnp-2671	73	42	than	than	ADP
fnp-2671	73	43	eight	eight	NUM
fnp-2671	73	44	molecular	molecular	ADJ
fnp-2671	73	45	subgroups	subgroup	NOUN
fnp-2671	73	46	in	in	ADP
fnp-2671	73	47	the	the	DET
fnp-2671	73	48	non	non	NOUN
fnp-2671	73	49	-	-	NOUN
fnp-2671	73	50	wnt	wnt	NOUN
fnp-2671	73	51	/	/	SYM
fnp-2671	73	52	non	non	ADJ
fnp-2671	73	53	-	-	ADJ
fnp-2671	73	54	shh	shh	ADJ
fnp-2671	73	55	category	category	NOUN
fnp-2671	73	56	.	.	PUNCT
fnp-2671	74	1	subtyping	subtype	VERB
fnp-2671	74	2	of	of	ADP
fnp-2671	74	3	non	non	NOUN
fnp-2671	74	4	-	-	ADJ
fnp-2671	74	5	wnt	wnt	NOUN
fnp-2671	74	6	/	/	SYM
fnp-2671	74	7	non	non	ADJ
fnp-2671	74	8	-	-	ADJ
fnp-2671	74	9	shh	shh	ADJ
fnp-2671	74	10	medulloblastomas	medulloblastoma	NOUN
fnp-2671	74	11	into	into	ADP
fnp-2671	74	12	subtype	subtype	NOUN
fnp-2671	74	13	i	i	PRON
fnp-2671	74	14	-	-	PUNCT
fnp-2671	74	15	viii	viii	PROPN
fnp-2671	74	16	is	be	AUX
fnp-2671	74	17	now	now	ADV
fnp-2671	74	18	available	available	ADJ
fnp-2671	74	19	for	for	ADP
fnp-2671	74	20	the	the	DET
fnp-2671	74	21	community	community	NOUN
fnp-2671	74	22	by	by	ADP
fnp-2671	74	23	performing	perform	VERB
fnp-2671	74	24	methylome	methylome	ADJ
fnp-2671	74	25	analysis	analysis	NOUN
fnp-2671	74	26	as	as	SCONJ
fnp-2671	74	27	described	describe	VERB
fnp-2671	74	28	by	by	ADP
fnp-2671	74	29	capper	capper	NOUN
fnp-2671	74	30	et	et	PROPN
fnp-2671	74	31	al	al	PROPN
fnp-2671	75	1	[	[	X
fnp-2671	75	2	24	24	NUM
fnp-2671	75	3	,	,	PUNCT
fnp-2671	75	4	25	25	NUM
fnp-2671	75	5	]	]	PUNCT
fnp-2671	75	6	and	and	CCONJ
fnp-2671	75	7	using	use	VERB
fnp-2671	75	8	an	an	DET
fnp-2671	75	9	extension	extension	NOUN
fnp-2671	75	10	of	of	ADP
fnp-2671	75	11	the	the	DET
fnp-2671	75	12	heidelberg	heidelberg	NOUN
fnp-2671	75	13	brain	brain	NOUN
fnp-2671	75	14	tumor	tumor	NOUN
fnp-2671	75	15	classifier	classifier	NOUN
fnp-2671	75	16	(	(	PUNCT
fnp-2671	75	17	https://www.molecularneuropathology.org/mnp/classifier/7	https://www.molecularneuropathology.org/mnp/classifier/7	PROPN
fnp-2671	75	18	)	)	PUNCT
fnp-2671	75	19	.	.	PUNCT
fnp-2671	76	1	topic	topic	NOUN
fnp-2671	76	2	4	4	NUM
fnp-2671	76	3	.	.	PUNCT
fnp-2671	76	4	histogenesis	histogenesis	NOUN
fnp-2671	76	5	of	of	ADP
fnp-2671	76	6	posterior	posterior	ADJ
fnp-2671	76	7	fossa	fossa	ADJ
fnp-2671	76	8	tumors	tumor	NOUN
fnp-2671	76	9	in	in	ADP
fnp-2671	76	10	children	child	NOUN
fnp-2671	77	1	[	[	X
fnp-2671	77	2	5	5	NUM
fnp-2671	77	3	-	-	SYM
fnp-2671	77	4	7	7	NUM
fnp-2671	77	5	]	]	PUNCT
fnp-2671	77	6	for	for	ADP
fnp-2671	77	7	quite	quite	DET
fnp-2671	77	8	some	some	DET
fnp-2671	77	9	time	time	NOUN
fnp-2671	77	10	it	it	PRON
fnp-2671	77	11	is	be	AUX
fnp-2671	77	12	clear	clear	ADJ
fnp-2671	77	13	that	that	SCONJ
fnp-2671	77	14	different	different	ADJ
fnp-2671	77	15	subtypes	subtype	NOUN
fnp-2671	77	16	of	of	ADP
fnp-2671	77	17	medulloblastomas	medulloblastoma	NOUN
fnp-2671	77	18	have	have	VERB
fnp-2671	77	19	different	different	ADJ
fnp-2671	77	20	developmental	developmental	ADJ
fnp-2671	77	21	origin	origin	NOUN
fnp-2671	77	22	[	[	X
fnp-2671	77	23	33	33	NUM
fnp-2671	77	24	]	]	PUNCT
fnp-2671	77	25	.	.	PUNCT
fnp-2671	78	1	in	in	ADP
fnp-2671	78	2	fact	fact	NOUN
fnp-2671	78	3	,	,	PUNCT
fnp-2671	78	4	cerebellar	cerebellar	ADJ
fnp-2671	78	5	tumors	tumor	NOUN
fnp-2671	78	6	may	may	AUX
fnp-2671	78	7	be	be	AUX
fnp-2671	78	8	the	the	DET
fnp-2671	78	9	result	result	NOUN
fnp-2671	78	10	of	of	ADP
fnp-2671	78	11	a	a	DET
fnp-2671	78	12	disorder	disorder	NOUN
fnp-2671	78	13	of	of	ADP
fnp-2671	78	14	early	early	ADJ
fnp-2671	78	15	cerebellar	cerebellar	ADJ
fnp-2671	78	16	development	development	NOUN
fnp-2671	78	17	.	.	PUNCT
fnp-2671	79	1	in	in	ADP
fnp-2671	79	2	an	an	DET
fnp-2671	79	3	attempt	attempt	NOUN
fnp-2671	79	4	to	to	PART
fnp-2671	79	5	further	far	ADV
fnp-2671	79	6	elucidate	elucidate	VERB
fnp-2671	79	7	cerebellar	cerebellar	ADJ
fnp-2671	79	8	development	development	NOUN
fnp-2671	79	9	at	at	ADP
fnp-2671	79	10	the	the	DET
fnp-2671	79	11	single	single	ADJ
fnp-2671	79	12	cell	cell	NOUN
fnp-2671	79	13	level	level	NOUN
fnp-2671	79	14	,	,	PUNCT
fnp-2671	79	15	vladiou	vladiou	NOUN
fnp-2671	79	16	et	et	PROPN
fnp-2671	79	17	al	al	PROPN
fnp-2671	79	18	performed	perform	VERB
fnp-2671	79	19	large	large	ADJ
fnp-2671	79	20	-	-	PUNCT
fnp-2671	79	21	scale	scale	NOUN
fnp-2671	79	22	single	single	ADJ
fnp-2671	79	23	-	-	PUNCT
fnp-2671	79	24	cell	cell	NOUN
fnp-2671	79	25	rna	rna	NOUN
fnp-2671	79	26	sequencing	sequence	VERB
fnp-2671	79	27	(	(	PUNCT
fnp-2671	79	28	scrna	scrna	NOUN
fnp-2671	79	29	-	-	PUNCT
fnp-2671	79	30	seq	seq	NOUN
fnp-2671	79	31	)	)	PUNCT
fnp-2671	79	32	of	of	ADP
fnp-2671	79	33	more	more	ADJ
fnp-2671	79	34	than	than	ADP
fnp-2671	79	35	60,000	60,000	NUM
fnp-2671	79	36	cells	cell	NOUN
fnp-2671	79	37	from	from	ADP
fnp-2671	79	38	the	the	DET
fnp-2671	79	39	developing	develop	VERB
fnp-2671	79	40	mouse	mouse	NOUN
fnp-2671	79	41	cerebellum	cerebellum	NOUN
fnp-2671	79	42	[	[	X
fnp-2671	79	43	5	5	NUM
fnp-2671	79	44	]	]	PUNCT
fnp-2671	79	45	.	.	PUNCT
fnp-2671	80	1	these	these	DET
fnp-2671	80	2	analyses	analysis	NOUN
fnp-2671	80	3	allowed	allow	VERB
fnp-2671	80	4	them	they	PRON
fnp-2671	80	5	to	to	PART
fnp-2671	80	6	reconstruct	reconstruct	VERB
fnp-2671	80	7	the	the	DET
fnp-2671	80	8	cellular	cellular	ADJ
fnp-2671	80	9	hierarchy	hierarchy	NOUN
fnp-2671	80	10	in	in	ADP
fnp-2671	80	11	development	development	NOUN
fnp-2671	80	12	at	at	ADP
fnp-2671	80	13	various	various	ADJ
fnp-2671	80	14	points	point	NOUN
fnp-2671	80	15	in	in	ADP
fnp-2671	80	16	time	time	NOUN
fnp-2671	80	17	,	,	PUNCT
fnp-2671	80	18	with	with	ADP
fnp-2671	80	19	many	many	ADJ
fnp-2671	80	20	of	of	ADP
fnp-2671	80	21	the	the	DET
fnp-2671	80	22	normal	normal	ADJ
fnp-2671	80	23	mouse	mouse	NOUN
fnp-2671	80	24	cerebellar	cerebellar	ADJ
fnp-2671	80	25	cell	cell	NOUN
fnp-2671	80	26	populations	population	NOUN
fnp-2671	80	27	only	only	ADV
fnp-2671	80	28	being	be	AUX
fnp-2671	80	29	present	present	ADJ
fnp-2671	80	30	for	for	ADP
fnp-2671	80	31	a	a	DET
fnp-2671	80	32	restricted	restrict	VERB
fnp-2671	80	33	time	time	NOUN
fnp-2671	80	34	period	period	NOUN
fnp-2671	80	35	during	during	ADP
fnp-2671	80	36	the	the	DET
fnp-2671	80	37	fetal	fetal	ADJ
fnp-2671	80	38	or	or	CCONJ
fnp-2671	80	39	very	very	ADV
fnp-2671	80	40	early	early	ADJ
fnp-2671	80	41	postnatal	postnatal	ADJ
fnp-2671	80	42	period	period	NOUN
fnp-2671	80	43	.	.	PUNCT
fnp-2671	81	1	subsequently	subsequently	ADV
fnp-2671	81	2	,	,	PUNCT
fnp-2671	81	3	this	this	DET
fnp-2671	81	4	transcriptome	transcriptome	ADJ
fnp-2671	81	5	information	information	NOUN
fnp-2671	81	6	was	be	AUX
fnp-2671	81	7	compared	compare	VERB
fnp-2671	81	8	to	to	ADP
fnp-2671	81	9	that	that	PRON
fnp-2671	81	10	of	of	ADP
fnp-2671	81	11	pediatric	pediatric	ADJ
fnp-2671	81	12	cerebellar	cerebellar	ADJ
fnp-2671	81	13	tumors	tumor	NOUN
fnp-2671	81	14	:	:	PUNCT
fnp-2671	81	15	medulloblastomas	medulloblastoma	NOUN
fnp-2671	81	16	,	,	PUNCT
fnp-2671	81	17	posterior	posterior	ADJ
fnp-2671	81	18	fossa	fossa	NOUN
fnp-2671	81	19	(	(	PUNCT
fnp-2671	81	20	pf	pf	NOUN
fnp-2671	81	21	)	)	PUNCT
fnp-2671	81	22	ependymomas	ependymoma	NOUN
fnp-2671	81	23	,	,	PUNCT
fnp-2671	81	24	and	and	CCONJ
fnp-2671	81	25	pilocytic	pilocytic	ADJ
fnp-2671	81	26	astrocytoma	astrocytoma	NOUN
fnp-2671	81	27	.	.	PUNCT
fnp-2671	82	1	the	the	DET
fnp-2671	82	2	authors	author	NOUN
fnp-2671	82	3	find	find	VERB
fnp-2671	82	4	that	that	SCONJ
fnp-2671	82	5	(	(	PUNCT
fnp-2671	82	6	different	different	ADJ
fnp-2671	82	7	molecular	molecular	ADJ
fnp-2671	82	8	subgroups	subgroup	NOUN
fnp-2671	82	9	of	of	ADP
fnp-2671	82	10	)	)	PUNCT
fnp-2671	82	11	these	these	DET
fnp-2671	82	12	tumors	tumor	NOUN
fnp-2671	82	13	indeed	indeed	ADV
fnp-2671	82	14	mirror	mirror	VERB
fnp-2671	82	15	the	the	DET
fnp-2671	82	16	transcription	transcription	NOUN
fnp-2671	82	17	of	of	ADP
fnp-2671	82	18	cells	cell	NOUN
fnp-2671	82	19	from	from	ADP
fnp-2671	82	20	distinct	distinct	ADJ
fnp-2671	82	21	,	,	PUNCT
fnp-2671	82	22	temporally	temporally	ADV
fnp-2671	82	23	restricted	restrict	VERB
fnp-2671	82	24	cerebellar	cerebellar	ADJ
fnp-2671	82	25	lineages	lineage	NOUN
fnp-2671	82	26	:	:	PUNCT
fnp-2671	82	27	shh	shh	NOUN
fnp-2671	82	28	medulloblastomas	medulloblastoma	NOUN
fnp-2671	82	29	,	,	PUNCT
fnp-2671	82	30	group	group	NOUN
fnp-2671	82	31	3	3	NUM
fnp-2671	82	32	and	and	CCONJ
fnp-2671	82	33	group	group	NOUN
fnp-2671	82	34	4	4	NUM
fnp-2671	82	35	medulloblastomas	medulloblastoma	NOUN
fnp-2671	82	36	were	be	AUX
fnp-2671	82	37	found	find	VERB
fnp-2671	82	38	to	to	PART
fnp-2671	82	39	transcriptionally	transcriptionally	ADV
fnp-2671	82	40	resemble	resemble	VERB
fnp-2671	82	41	respectively	respectively	ADV
fnp-2671	82	42	the	the	DET
fnp-2671	82	43	granule	granule	NOUN
fnp-2671	82	44	cell	cell	NOUN
fnp-2671	82	45	hierarchy	hierarchy	NOUN
fnp-2671	82	46	,	,	PUNCT
fnp-2671	82	47	nestin+	nestin+	PROPN
fnp-2671	82	48	stem	stem	NOUN
fnp-2671	82	49	cells	cell	NOUN
fnp-2671	82	50	,	,	PUNCT
fnp-2671	82	51	and	and	CCONJ
fnp-2671	82	52	unipolar	unipolar	ADJ
fnp-2671	82	53	brush	brush	NOUN
fnp-2671	82	54	cells	cell	NOUN
fnp-2671	82	55	,	,	PUNCT
fnp-2671	82	56	while	while	SCONJ
fnp-2671	82	57	pf	pf	PROPN
fnp-2671	82	58	type	type	VERB
fnp-2671	82	59	a	a	DET
fnp-2671	82	60	/	/	SYM
fnp-2671	82	61	pf	pf	NOUN
fnp-2671	82	62	type	type	NOUN
fnp-2671	82	63	b	b	PROPN
fnp-2671	82	64	(	(	PUNCT
fnp-2671	82	65	pfa	pfa	NOUN
fnp-2671	82	66	/	/	SYM
fnp-2671	82	67	pfb	pfb	NOUN
fnp-2671	82	68	)	)	PUNCT
fnp-2671	82	69	ependymomas	ependymomas	PROPN
fnp-2671	82	70	and	and	CCONJ
fnp-2671	82	71	cerebellar	cerebellar	ADJ
fnp-2671	82	72	pilocytic	pilocytic	ADJ
fnp-2671	82	73	astrocytomas	astrocytoma	NOUN
fnp-2671	82	74	resembled	resemble	VERB
fnp-2671	82	75	prenatal	prenatal	ADJ
fnp-2671	82	76	gliogenic	gliogenic	ADJ
fnp-2671	82	77	progenitor	progenitor	NOUN
fnp-2671	82	78	cells	cell	NOUN
fnp-2671	82	79	.	.	PUNCT
fnp-2671	83	1	these	these	DET
fnp-2671	83	2	findings	finding	NOUN
fnp-2671	83	3	indicate	indicate	VERB
fnp-2671	83	4	that	that	SCONJ
fnp-2671	83	5	each	each	PRON
fnp-2671	83	6	of	of	ADP
fnp-2671	83	7	these	these	DET
fnp-2671	83	8	cerebellar	cerebellar	ADJ
fnp-2671	83	9	tumor	tumor	NOUN
fnp-2671	83	10	types	type	NOUN
fnp-2671	83	11	arises	arise	VERB
fnp-2671	83	12	from	from	ADP
fnp-2671	83	13	a	a	DET
fnp-2671	83	14	particular	particular	ADJ
fnp-2671	83	15	cell	cell	NOUN
fnp-2671	83	16	type	type	NOUN
fnp-2671	83	17	.	.	PUNCT
fnp-2671	84	1	however	however	ADV
fnp-2671	84	2	,	,	PUNCT
fnp-2671	84	3	across	across	ADP
fnp-2671	84	4	the	the	DET
fnp-2671	84	5	medulloblastoma	medulloblastoma	NOUN
fnp-2671	84	6	subgroups	subgroup	NOUN
fnp-2671	84	7	(	(	PUNCT
fnp-2671	84	8	shh	shh	INTJ
fnp-2671	84	9	,	,	PUNCT
fnp-2671	84	10	group	group	NOUN
fnp-2671	84	11	3	3	NUM
fnp-2671	84	12	,	,	PUNCT
fnp-2671	84	13	group	group	NOUN
fnp-2671	84	14	4	4	NUM
fnp-2671	84	15	)	)	PUNCT
fnp-2671	84	16	,	,	PUNCT
fnp-2671	84	17	as	as	ADV
fnp-2671	84	18	well	well	ADV
fnp-2671	84	19	as	as	ADP
fnp-2671	84	20	pfa	pfa	PROPN
fnp-2671	84	21	ependymoma	ependymoma	NOUN
fnp-2671	84	22	and	and	CCONJ
fnp-2671	84	23	pilocytic	pilocytic	ADJ
fnp-2671	84	24	astrocytomas	astrocytoma	NOUN
fnp-2671	84	25	,	,	PUNCT
fnp-2671	84	26	the	the	DET
fnp-2671	84	27	scrnaseq	scrnaseq	NOUN
fnp-2671	84	28	data	datum	NOUN
fnp-2671	84	29	also	also	ADV
fnp-2671	84	30	demonstrated	demonstrate	VERB
fnp-2671	84	31	high	high	ADJ
fnp-2671	84	32	levels	level	NOUN
fnp-2671	84	33	of	of	ADP
fnp-2671	84	34	single	single	ADJ
fnp-2671	84	35	-	-	PUNCT
fnp-2671	84	36	cell	cell	NOUN
fnp-2671	84	37	heterogeneity	heterogeneity	NOUN
fnp-2671	84	38	,	,	PUNCT
fnp-2671	84	39	with	with	ADP
fnp-2671	84	40	evidence	evidence	NOUN
fnp-2671	84	41	of	of	ADP
fnp-2671	84	42	multiple	multiple	ADJ
fnp-2671	84	43	lineages	lineage	NOUN
fnp-2671	84	44	of	of	ADP
fnp-2671	84	45	differentiation	differentiation	NOUN
fnp-2671	84	46	and	and	CCONJ
fnp-2671	84	47	tumor	tumor	NOUN
fnp-2671	84	48	cells	cell	NOUN
fnp-2671	84	49	matching	match	VERB
fnp-2671	84	50	different	different	ADJ
fnp-2671	84	51	time	time	NOUN
fnp-2671	84	52	points	point	NOUN
fnp-2671	84	53	in	in	ADP
fnp-2671	84	54	the	the	DET
fnp-2671	84	55	differentiation	differentiation	NOUN
fnp-2671	84	56	hierarchy	hierarchy	NOUN
fnp-2671	84	57	[	[	X
fnp-2671	84	58	5	5	NUM
fnp-2671	84	59	]	]	PUNCT
fnp-2671	84	60	.	.	PUNCT
fnp-2671	85	1	in	in	ADP
fnp-2671	85	2	another	another	DET
fnp-2671	85	3	study	study	NOUN
fnp-2671	85	4	,	,	PUNCT
fnp-2671	85	5	hovestadt	hovestadt	ADJ
fnp-2671	85	6	et	et	PROPN
fnp-2671	85	7	al	al	PROPN
fnp-2671	85	8	performed	perform	VERB
fnp-2671	85	9	single	single	ADJ
fnp-2671	85	10	-	-	PUNCT
fnp-2671	85	11	cell	cell	NOUN
fnp-2671	85	12	transcriptomics	transcriptomic	NOUN
fnp-2671	85	13	to	to	PART
fnp-2671	85	14	investigate	investigate	VERB
fnp-2671	85	15	intraand	intraand	NOUN
fnp-2671	85	16	intertumoral	intertumoral	ADJ
fnp-2671	85	17	heterogeneity	heterogeneity	NOUN
fnp-2671	85	18	in	in	ADP
fnp-2671	85	19	25	25	NUM
fnp-2671	85	20	medulloblastomas	medulloblastoma	NOUN
fnp-2671	85	21	spanning	span	VERB
fnp-2671	85	22	all	all	DET
fnp-2671	85	23	molecular	molecular	ADJ
fnp-2671	85	24	subgroups	subgroup	NOUN
fnp-2671	85	25	.	.	PUNCT
fnp-2671	86	1	they	they	PRON
fnp-2671	86	2	find	find	VERB
fnp-2671	86	3	that	that	SCONJ
fnp-2671	86	4	wnt	wnt	PROPN
fnp-2671	86	5	,	,	PUNCT
fnp-2671	86	6	shh	shh	NOUN
fnp-2671	86	7	and	and	CCONJ
fnp-2671	86	8	group	group	PROPN
fnp-2671	86	9	3	3	NUM
fnp-2671	86	10	tumors	tumor	NOUN
fnp-2671	86	11	comprise	comprise	VERB
fnp-2671	86	12	subgroup	subgroup	NOUN
fnp-2671	86	13	-	-	PUNCT
fnp-2671	86	14	specific	specific	NOUN
fnp-2671	86	15	undifferentiated	undifferentiated	ADJ
fnp-2671	86	16	and	and	CCONJ
fnp-2671	86	17	differentiated	differentiated	ADJ
fnp-2671	86	18	neuronal	neuronal	ADJ
fnp-2671	86	19	-	-	PUNCT
fnp-2671	86	20	like	like	ADJ
fnp-2671	86	21	populations	population	NOUN
fnp-2671	86	22	of	of	ADP
fnp-2671	86	23	malignant	malignant	ADJ
fnp-2671	86	24	cells	cell	NOUN
fnp-2671	86	25	,	,	PUNCT
fnp-2671	86	26	whereas	whereas	SCONJ
fnp-2671	86	27	group	group	NOUN
fnp-2671	86	28	4	4	NUM
fnp-2671	86	29	tumors	tumor	NOUN
fnp-2671	86	30	consist	consist	VERB
fnp-2671	86	31	of	of	ADP
fnp-2671	86	32	differentiated	differentiated	ADJ
fnp-2671	86	33	neuronal	neuronal	ADJ
fnp-2671	86	34	-	-	PUNCT
fnp-2671	86	35	like	like	ADJ
fnp-2671	86	36	neoplastic	neoplastic	ADJ
fnp-2671	86	37	cells	cell	NOUN
fnp-2671	86	38	.	.	PUNCT
fnp-2671	87	1	the	the	DET
fnp-2671	87	2	tumor	tumor	NOUN
fnp-2671	87	3	cells	cell	NOUN
fnp-2671	87	4	in	in	ADP
fnp-2671	87	5	shh	shh	PROPN
fnp-2671	87	6	medulloblastomas	medulloblastoma	NOUN
fnp-2671	87	7	closely	closely	ADV
fnp-2671	87	8	resembled	resemble	VERB
fnp-2671	87	9	granule	granule	NOUN
fnp-2671	87	10	neurons	neuron	NOUN
fnp-2671	87	11	of	of	ADP
fnp-2671	87	12	varying	vary	VERB
fnp-2671	87	13	differentiation	differentiation	NOUN
fnp-2671	87	14	states	state	NOUN
fnp-2671	87	15	that	that	PRON
fnp-2671	87	16	correlated	correlate	VERB
fnp-2671	87	17	with	with	ADP
fnp-2671	87	18	patient	patient	ADJ
fnp-2671	87	19	age	age	NOUN
fnp-2671	87	20	.	.	PUNCT
fnp-2671	88	1	using	use	VERB
fnp-2671	88	2	cross	cross	ADJ
fnp-2671	88	3	-	-	ADJ
fnp-2671	88	4	species	species	ADJ
fnp-2671	88	5	transcriptomic	transcriptomic	ADJ
fnp-2671	88	6	analysis	analysis	NOUN
fnp-2671	88	7	,	,	PUNCT
fnp-2671	88	8	it	it	PRON
fnp-2671	88	9	appeared	appear	VERB
fnp-2671	88	10	that	that	SCONJ
fnp-2671	88	11	distinct	distinct	ADJ
fnp-2671	88	12	glutamatergic	glutamatergic	ADJ
fnp-2671	88	13	populations	population	NOUN
fnp-2671	88	14	are	be	AUX
fnp-2671	88	15	the	the	DET
fnp-2671	88	16	putative	putative	ADJ
fnp-2671	88	17	cells	cell	NOUN
fnp-2671	88	18	-	-	PUNCT
fnp-2671	88	19	of	of	ADP
fnp-2671	88	20	-	-	PUNCT
fnp-2671	88	21	origin	origin	NOUN
fnp-2671	88	22	for	for	ADP
fnp-2671	88	23	shh	shh	PROPN
fnp-2671	88	24	and	and	CCONJ
fnp-2671	88	25	group	group	NOUN
fnp-2671	88	26	4	4	NUM
fnp-2671	88	27	medulloblastomas	medulloblastoma	NOUN
fnp-2671	88	28	.	.	PUNCT
fnp-2671	89	1	furthermore	furthermore	ADV
fnp-2671	89	2	,	,	PUNCT
fnp-2671	89	3	the	the	DET
fnp-2671	89	4	tumor	tumor	NOUN
fnp-2671	89	5	cells	cell	NOUN
fnp-2671	89	6	of	of	ADP
fnp-2671	89	7	group	group	NOUN
fnp-2671	89	8	3	3	NUM
fnp-2671	89	9	and	and	CCONJ
fnp-2671	89	10	group	group	NOUN
fnp-2671	89	11	4	4	NUM
fnp-2671	89	12	medulloblastomas	medulloblastoma	NOUN
fnp-2671	89	13	exhibited	exhibit	VERB
fnp-2671	89	14	characteristics	characteristic	NOUN
fnp-2671	89	15	ranging	range	VERB
fnp-2671	89	16	from	from	ADP
fnp-2671	89	17	primitive	primitive	ADJ
fnp-2671	89	18	progenitor	progenitor	NOUN
fnp-2671	89	19	-	-	PUNCT
fnp-2671	89	20	like	like	ADJ
fnp-2671	89	21	to	to	PART
fnp-2671	89	22	more	more	ADV
fnp-2671	89	23	mature	mature	ADJ
fnp-2671	89	24	neuronal	neuronal	ADJ
fnp-2671	89	25	-	-	PUNCT
fnp-2671	89	26	like	like	ADJ
fnp-2671	89	27	cells	cell	NOUN
fnp-2671	89	28	,	,	PUNCT
fnp-2671	89	29	with	with	ADP
fnp-2671	89	30	the	the	DET
fnp-2671	89	31	relative	relative	ADJ
fnp-2671	89	32	proportions	proportion	NOUN
fnp-2671	89	33	of	of	ADP
fnp-2671	89	34	these	these	DET
fnp-2671	89	35	cells	cell	NOUN
fnp-2671	89	36	distinguishing	distinguish	VERB
fnp-2671	89	37	these	these	DET
fnp-2671	89	38	subgroups	subgroup	NOUN
fnp-2671	89	39	[	[	X
fnp-2671	89	40	6	6	NUM
fnp-2671	89	41	]	]	PUNCT
fnp-2671	89	42	.	.	PUNCT
fnp-2671	90	1	in	in	ADP
fnp-2671	90	2	a	a	DET
fnp-2671	90	3	third	third	ADJ
fnp-2671	90	4	study	study	NOUN
fnp-2671	90	5	,	,	PUNCT
fnp-2671	90	6	based	base	VERB
fnp-2671	90	7	on	on	ADP
fnp-2671	90	8	single	single	ADJ
fnp-2671	90	9	-	-	PUNCT
fnp-2671	90	10	cell	cell	NOUN
fnp-2671	90	11	transcriptome	transcriptome	ADJ
fnp-2671	90	12	analysis	analysis	NOUN
fnp-2671	90	13	of	of	ADP
fnp-2671	90	14	>	>	ADP
fnp-2671	90	15	65,000	65,000	NUM
fnp-2671	90	16	cells	cell	NOUN
fnp-2671	90	17	of	of	ADP
fnp-2671	90	18	the	the	DET
fnp-2671	90	19	embryonal	embryonal	ADJ
fnp-2671	90	20	pons	pon	NOUN
fnp-2671	90	21	and	and	CCONJ
fnp-2671	90	22	forebrain	forebrain	NOUN
fnp-2671	90	23	,	,	PUNCT
fnp-2671	90	24	jessa	jessa	PROPN
fnp-2671	90	25	et	et	PROPN
fnp-2671	90	26	al	al	PROPN
fnp-2671	90	27	derived	derive	VERB
fnp-2671	90	28	signatures	signature	NOUN
fnp-2671	90	29	for	for	ADP
fnp-2671	90	30	191	191	NUM
fnp-2671	90	31	distinct	distinct	ADJ
fnp-2671	90	32	cell	cell	NOUN
fnp-2671	90	33	populations	population	NOUN
fnp-2671	90	34	of	of	ADP
fnp-2671	90	35	these	these	DET
fnp-2671	90	36	regions	region	NOUN
fnp-2671	90	37	[	[	X
fnp-2671	90	38	7	7	NUM
fnp-2671	90	39	]	]	PUNCT
fnp-2671	90	40	.	.	PUNCT
fnp-2671	91	1	bulk	bulk	ADJ
fnp-2671	91	2	transcriptome	transcriptome	ADJ
fnp-2671	91	3	analysis	analysis	NOUN
fnp-2671	91	4	of	of	ADP
fnp-2671	91	5	wnt	wnt	NOUN
fnp-2671	91	6	-	-	PUNCT
fnp-2671	91	7	activated	activate	VERB
fnp-2671	91	8	medulloblastomas	medulloblastoma	NOUN
fnp-2671	91	9	revealed	reveal	VERB
fnp-2671	91	10	a	a	DET
fnp-2671	91	11	match	match	NOUN
fnp-2671	91	12	with	with	ADP
fnp-2671	91	13	the	the	DET
fnp-2671	91	14	mossy	mossy	NOUN
fnp-2671	91	15	fiber	fiber	NOUN
fnp-2671	91	16	neuronal	neuronal	ADJ
fnp-2671	91	17	lineage	lineage	NOUN
fnp-2671	91	18	of	of	ADP
fnp-2671	91	19	the	the	DET
fnp-2671	91	20	rhombic	rhombic	ADJ
fnp-2671	91	21	lip	lip	NOUN
fnp-2671	91	22	.	.	PUNCT
fnp-2671	92	1	embryonal	embryonal	ADJ
fnp-2671	92	2	tumors	tumor	NOUN
fnp-2671	92	3	with	with	ADP
fnp-2671	92	4	multilayered	multilayered	ADJ
fnp-2671	92	5	rosettes	rosette	NOUN
fnp-2671	92	6	(	(	PUNCT
fnp-2671	92	7	etmrs	etmrs	NOUN
fnp-2671	92	8	)	)	PUNCT
fnp-2671	92	9	appeared	appear	VERB
fnp-2671	92	10	to	to	PART
fnp-2671	92	11	be	be	AUX
fnp-2671	92	12	derived	derive	VERB
fnp-2671	92	13	from	from	ADP
fnp-2671	92	14	a	a	DET
fnp-2671	92	15	neuronal	neuronal	ADJ
fnp-2671	92	16	lineage	lineage	NOUN
fnp-2671	92	17	as	as	ADV
fnp-2671	92	18	well	well	ADV
fnp-2671	92	19	,	,	PUNCT
fnp-2671	92	20	but	but	CCONJ
fnp-2671	92	21	especially	especially	ADV
fnp-2671	92	22	the	the	DET
fnp-2671	92	23	tyr	tyr	PROPN
fnp-2671	92	24	and	and	CCONJ
fnp-2671	92	25	myc	myc	PROPN
fnp-2671	92	26	subgroups	subgroup	NOUN
fnp-2671	92	27	of	of	ADP
fnp-2671	92	28	atypical	atypical	ADJ
fnp-2671	92	29	teratoid	teratoid	NOUN
fnp-2671	92	30	/	/	SYM
fnp-2671	92	31	rhabdoid	rhabdoid	NOUN
fnp-2671	92	32	tumor	tumor	NOUN
fnp-2671	92	33	(	(	PUNCT
fnp-2671	92	34	at	at	ADP
fnp-2671	92	35	/	/	SYM
fnp-2671	92	36	rt	rt	PROPN
fnp-2671	92	37	)	)	PUNCT
fnp-2671	92	38	seemed	seem	VERB
fnp-2671	92	39	to	to	PART
fnp-2671	92	40	originate	originate	VERB
fnp-2671	92	41	from	from	ADP
fnp-2671	92	42	non	non	ADJ
fnp-2671	92	43	-	-	ADJ
fnp-2671	92	44	neuroectodermal	neuroectodermal	ADJ
fnp-2671	92	45	cells	cell	NOUN
fnp-2671	92	46	.	.	PUNCT
fnp-2671	93	1	all	all	ADV
fnp-2671	93	2	in	in	ADP
fnp-2671	93	3	all	all	PRON
fnp-2671	93	4	,	,	PUNCT
fnp-2671	93	5	these	these	DET
fnp-2671	93	6	studies	study	NOUN
fnp-2671	93	7	provide	provide	VERB
fnp-2671	93	8	strong	strong	ADJ
fnp-2671	93	9	evidence	evidence	NOUN
fnp-2671	93	10	that	that	SCONJ
fnp-2671	93	11	pediatric	pediatric	ADJ
fnp-2671	93	12	cns	cns	NOUN
fnp-2671	93	13	tumors	tumor	NOUN
fnp-2671	93	14	are	be	AUX
fnp-2671	93	15	the	the	DET
fnp-2671	93	16	result	result	NOUN
fnp-2671	93	17	of	of	ADP
fnp-2671	93	18	a	a	DET
fnp-2671	93	19	disorder	disorder	NOUN
fnp-2671	93	20	of	of	ADP
fnp-2671	93	21	early	early	ADJ
fnp-2671	93	22	development	development	NOUN
fnp-2671	93	23	,	,	PUNCT
fnp-2671	93	24	although	although	SCONJ
fnp-2671	93	25	the	the	DET
fnp-2671	93	26	possibility	possibility	NOUN
fnp-2671	93	27	that	that	SCONJ
fnp-2671	93	28	they	they	PRON
fnp-2671	93	29	arise	arise	VERB
fnp-2671	93	30	from	from	ADP
fnp-2671	93	31	more	more	ADJ
fnp-2671	93	32	mature	mature	ADJ
fnp-2671	93	33	cells	cell	NOUN
fnp-2671	93	34	undergoing	undergo	VERB
fnp-2671	93	35	de	de	NOUN
fnp-2671	93	36	-	-	NOUN
fnp-2671	93	37	differentiation	differentiation	NOUN
fnp-2671	93	38	at	at	ADP
fnp-2671	93	39	later	later	ADJ
fnp-2671	93	40	time	time	NOUN
fnp-2671	93	41	points	point	NOUN
fnp-2671	93	42	or	or	CCONJ
fnp-2671	93	43	from	from	ADP
fnp-2671	93	44	trans	tran	NOUN
fnp-2671	93	45	-	-	NOUN
fnp-2671	93	46	differentiation	differentiation	NOUN
fnp-2671	93	47	of	of	ADP
fnp-2671	93	48	other	other	ADJ
fnp-2671	93	49	cell	cell	NOUN
fnp-2671	93	50	lineages	lineage	NOUN
fnp-2671	93	51	can	can	AUX
fnp-2671	93	52	not	not	PART
fnp-2671	93	53	yet	yet	ADV
fnp-2671	93	54	be	be	AUX
fnp-2671	93	55	completely	completely	ADV
fnp-2671	93	56	ruled	rule	VERB
fnp-2671	93	57	out	out	ADP
fnp-2671	93	58	.	.	PUNCT
fnp-2671	94	1	topic	topic	NOUN
fnp-2671	94	2	5	5	NUM
fnp-2671	94	3	.	.	PUNCT
fnp-2671	94	4	longitudinal	longitudinal	ADJ
fnp-2671	94	5	molecular	molecular	ADJ
fnp-2671	94	6	analysis	analysis	NOUN
fnp-2671	94	7	of	of	ADP
fnp-2671	94	8	diffuse	diffuse	ADJ
fnp-2671	94	9	gliomas	glioma	NOUN
fnp-2671	94	10	[	[	X
fnp-2671	94	11	8	8	NUM
fnp-2671	94	12	]	]	PUNCT
fnp-2671	94	13	genomic	genomic	ADJ
fnp-2671	94	14	characterization	characterization	NOUN
fnp-2671	94	15	efforts	effort	NOUN
fnp-2671	94	16	such	such	ADJ
fnp-2671	94	17	as	as	ADP
fnp-2671	94	18	the	the	DET
fnp-2671	94	19	cancer	cancer	NOUN
fnp-2671	94	20	genome	genome	NOUN
fnp-2671	94	21	atlas	atlas	PROPN
fnp-2671	94	22	(	(	PUNCT
fnp-2671	94	23	tcga	tcga	PROPN
fnp-2671	94	24	)	)	PUNCT
fnp-2671	94	25	have	have	AUX
fnp-2671	94	26	greatly	greatly	ADV
fnp-2671	94	27	increased	increase	VERB
fnp-2671	94	28	our	our	PRON
fnp-2671	94	29	understanding	understanding	NOUN
fnp-2671	94	30	of	of	ADP
fnp-2671	94	31	glioma	glioma	NOUN
fnp-2671	94	32	biology	biology	NOUN
fnp-2671	95	1	[	[	X
fnp-2671	95	2	34	34	NUM
fnp-2671	95	3	-	-	SYM
fnp-2671	95	4	37	37	NUM
fnp-2671	95	5	]	]	PUNCT
fnp-2671	95	6	.	.	PUNCT
fnp-2671	96	1	based	base	VERB
fnp-2671	96	2	on	on	ADP
fnp-2671	96	3	these	these	DET
fnp-2671	96	4	findings	finding	NOUN
fnp-2671	96	5	three	three	NUM
fnp-2671	96	6	major	major	ADJ
fnp-2671	96	7	,	,	PUNCT
fnp-2671	96	8	clinically	clinically	ADV
fnp-2671	96	9	relevant	relevant	ADJ
fnp-2671	96	10	subgroups	subgroup	NOUN
fnp-2671	96	11	of	of	ADP
fnp-2671	96	12	diffuse	diffuse	ADJ
fnp-2671	96	13	gliomas	glioma	NOUN
fnp-2671	96	14	in	in	ADP
fnp-2671	96	15	adults	adult	NOUN
fnp-2671	96	16	were	be	AUX
fnp-2671	96	17	introduced	introduce	VERB
fnp-2671	96	18	in	in	ADP
fnp-2671	96	19	the	the	DET
fnp-2671	96	20	who	who	PRON
fnp-2671	96	21	2016	2016	NUM
fnp-2671	96	22	classification	classification	NOUN
fnp-2671	96	23	of	of	ADP
fnp-2671	96	24	cns	cns	NOUN
fnp-2671	96	25	tumors	tumor	NOUN
fnp-2671	96	26	:	:	PUNCT
fnp-2671	96	27	(	(	PUNCT
fnp-2671	96	28	1	1	X
fnp-2671	96	29	)	)	PUNCT
fnp-2671	96	30	idh	idh	NOUN
fnp-2671	96	31	-	-	PUNCT
fnp-2671	96	32	mutant	mutant	NOUN
fnp-2671	96	33	and	and	CCONJ
fnp-2671	96	34	chromosome	chromosome	NOUN
fnp-2671	96	35	1p/19q	1p/19q	NOUN
fnp-2671	96	36	codeleted	codelete	VERB
fnp-2671	96	37	(	(	PUNCT
fnp-2671	96	38	idh	idh	NOUN
fnp-2671	96	39	-	-	PUNCT
fnp-2671	96	40	mutant	mutant	NOUN
fnp-2671	96	41	-	-	PUNCT
fnp-2671	96	42	codel	codel	NOUN
fnp-2671	96	43	)	)	PUNCT
fnp-2671	96	44	;	;	PUNCT
fnp-2671	96	45	(	(	PUNCT
fnp-2671	96	46	2	2	X
fnp-2671	96	47	)	)	PUNCT
fnp-2671	96	48	idh	idh	NOUN
fnp-2671	96	49	-	-	PUNCT
fnp-2671	96	50	mutant	mutant	NOUN
fnp-2671	96	51	without	without	ADP
fnp-2671	96	52	codeletion	codeletion	NOUN
fnp-2671	96	53	of	of	ADP
fnp-2671	96	54	chromosome	chromosome	NOUN
fnp-2671	96	55	1p/19q	1p/19q	NOUN
fnp-2671	96	56	(	(	PUNCT
fnp-2671	96	57	idh	idh	NOUN
fnp-2671	96	58	-	-	PUNCT
fnp-2671	96	59	mutant	mutant	NOUN
fnp-2671	96	60	-	-	PUNCT
fnp-2671	96	61	noncodel	noncodel	NOUN
fnp-2671	96	62	)	)	PUNCT
fnp-2671	96	63	;	;	PUNCT
fnp-2671	96	64	and	and	CCONJ
fnp-2671	96	65	(	(	PUNCT
fnp-2671	96	66	3	3	X
fnp-2671	96	67	)	)	PUNCT
fnp-2671	96	68	idh	idh	NOUN
fnp-2671	96	69	-	-	PUNCT
fnp-2671	96	70	wildtype	wildtype	NOUN
fnp-2671	96	71	.	.	PUNCT
fnp-2671	97	1	so	so	ADV
fnp-2671	97	2	far	far	ADV
fnp-2671	97	3	,	,	PUNCT
fnp-2671	97	4	however	however	ADV
fnp-2671	97	5	,	,	PUNCT
fnp-2671	97	6	such	such	ADJ
fnp-2671	97	7	studies	study	NOUN
fnp-2671	97	8	were	be	AUX
fnp-2671	97	9	generally	generally	ADV
fnp-2671	97	10	limited	limit	VERB
fnp-2671	97	11	to	to	ADP
fnp-2671	97	12	analysis	analysis	NOUN
fnp-2671	97	13	of	of	ADP
fnp-2671	97	14	tumor	tumor	NOUN
fnp-2671	97	15	tissue	tissue	NOUN
fnp-2671	97	16	as	as	SCONJ
fnp-2671	97	17	obtained	obtain	VERB
fnp-2671	97	18	by	by	ADP
fnp-2671	97	19	first	first	ADJ
fnp-2671	97	20	operation	operation	NOUN
fnp-2671	97	21	,	,	PUNCT
fnp-2671	97	22	and	and	CCONJ
fnp-2671	97	23	how	how	SCONJ
fnp-2671	97	24	the	the	DET
fnp-2671	97	25	genetic	genetic	ADJ
fnp-2671	97	26	landscape	landscape	NOUN
fnp-2671	97	27	of	of	ADP
fnp-2671	97	28	these	these	DET
fnp-2671	97	29	gliomas	glioma	NOUN
fnp-2671	97	30	evolves	evolve	VERB
fnp-2671	97	31	over	over	ADP
fnp-2671	97	32	time	time	NOUN
fnp-2671	97	33	and	and	CCONJ
fnp-2671	97	34	in	in	ADP
fnp-2671	97	35	response	response	NOUN
fnp-2671	97	36	to	to	ADP
fnp-2671	97	37	therapy	therapy	NOUN
fnp-2671	97	38	remained	remain	VERB
fnp-2671	97	39	largely	largely	ADV
fnp-2671	97	40	unknown	unknown	ADJ
fnp-2671	97	41	.	.	PUNCT
fnp-2671	98	1	in	in	ADP
fnp-2671	98	2	december	december	PROPN
fnp-2671	98	3	2019	2019	NUM
fnp-2671	98	4	,	,	PUNCT
fnp-2671	98	5	the	the	DET
fnp-2671	98	6	glioma	glioma	ADJ
fnp-2671	98	7	longitudinal	longitudinal	ADJ
fnp-2671	98	8	analysis	analysis	NOUN
fnp-2671	98	9	(	(	PUNCT
fnp-2671	98	10	glass	glass	NOUN
fnp-2671	98	11	)	)	PUNCT
fnp-2671	98	12	consortium	consortium	NOUN
fnp-2671	98	13	published	publish	VERB
fnp-2671	98	14	the	the	DET
fnp-2671	98	15	results	result	NOUN
fnp-2671	98	16	of	of	ADP
fnp-2671	98	17	analysis	analysis	NOUN
fnp-2671	98	18	of	of	ADP
fnp-2671	98	19	222	222	NUM
fnp-2671	98	20	diffuse	diffuse	ADJ
fnp-2671	98	21	glioma	glioma	NOUN
fnp-2671	98	22	patients	patient	NOUN
fnp-2671	98	23	(	(	PUNCT
fnp-2671	98	24	25	25	NUM
fnp-2671	98	25	idh	idh	NOUN
fnp-2671	98	26	-	-	PUNCT
fnp-2671	98	27	mutant	mutant	NOUN
fnp-2671	98	28	-	-	PUNCT
fnp-2671	98	29	codel	codel	ADJ
fnp-2671	98	30	,	,	PUNCT
fnp-2671	98	31	63	63	NUM
fnp-2671	98	32	idh	idh	NOUN
fnp-2671	98	33	-	-	PUNCT
fnp-2671	98	34	mutant	mutant	NOUN
fnp-2671	98	35	-	-	PUNCT
fnp-2671	98	36	noncodel	noncodel	NOUN
fnp-2671	98	37	,	,	PUNCT
fnp-2671	98	38	and	and	CCONJ
fnp-2671	98	39	134	134	NUM
fnp-2671	98	40	idh	idh	NOUN
fnp-2671	98	41	-	-	PUNCT
fnp-2671	98	42	wildtype	wildtype	NOUN
fnp-2671	98	43	)	)	PUNCT
fnp-2671	98	44	with	with	ADP
fnp-2671	98	45	high	high	ADJ
fnp-2671	98	46	-	-	PUNCT
fnp-2671	98	47	quality	quality	NOUN
fnp-2671	98	48	data	datum	NOUN
fnp-2671	98	49	on	on	ADP
fnp-2671	98	50	mutations	mutation	NOUN
fnp-2671	98	51	and	and	CCONJ
fnp-2671	98	52	chromosomal	chromosomal	ADJ
fnp-2671	98	53	copy	copy	NOUN
fnp-2671	98	54	numbers	number	NOUN
fnp-2671	98	55	in	in	ADP
fnp-2671	98	56	samples	sample	NOUN
fnp-2671	98	57	of	of	ADP
fnp-2671	98	58	at	at	ADV
fnp-2671	98	59	least	least	ADV
fnp-2671	98	60	two	two	NUM
fnp-2671	98	61	time	time	NOUN
fnp-2671	98	62	points	point	NOUN
fnp-2671	98	63	[	[	X
fnp-2671	98	64	8	8	NUM
fnp-2671	98	65	]	]	PUNCT
fnp-2671	98	66	.	.	PUNCT
fnp-2671	99	1	the	the	DET
fnp-2671	99	2	study	study	NOUN
fnp-2671	99	3	revealed	reveal	VERB
fnp-2671	99	4	that	that	SCONJ
fnp-2671	99	5	the	the	DET
fnp-2671	99	6	driver	driver	NOUN
fnp-2671	99	7	genes	gene	NOUN
fnp-2671	99	8	detected	detect	VERB
fnp-2671	99	9	in	in	ADP
fnp-2671	99	10	the	the	DET
fnp-2671	99	11	initial	initial	ADJ
fnp-2671	99	12	sample	sample	NOUN
fnp-2671	99	13	were	be	AUX
fnp-2671	99	14	retained	retain	VERB
fnp-2671	99	15	in	in	ADP
fnp-2671	99	16	the	the	DET
fnp-2671	99	17	recurrent	recurrent	ADJ
fnp-2671	99	18	tumor	tumor	NOUN
fnp-2671	99	19	,	,	PUNCT
fnp-2671	99	20	and	and	CCONJ
fnp-2671	99	21	there	there	PRON
fnp-2671	99	22	was	be	VERB
fnp-2671	99	23	little	little	ADJ
fnp-2671	99	24	evidence	evidence	NOUN
fnp-2671	99	25	of	of	ADP
fnp-2671	99	26	recurrence	recurrence	NOUN
fnp-2671	99	27	-	-	PUNCT
fnp-2671	99	28	specific	specific	ADJ
fnp-2671	99	29	gene	gene	NOUN
fnp-2671	99	30	alterations	alteration	NOUN
fnp-2671	99	31	.	.	PUNCT
fnp-2671	100	1	also	also	ADV
fnp-2671	100	2	,	,	PUNCT
fnp-2671	100	3	current	current	ADJ
fnp-2671	100	4	standard	standard	NOUN
fnp-2671	100	5	of	of	ADP
fnp-2671	100	6	care	care	NOUN
fnp-2671	100	7	therapies	therapy	NOUN
fnp-2671	100	8	(	(	PUNCT
fnp-2671	100	9	chemotherapy	chemotherapy	NOUN
fnp-2671	100	10	,	,	PUNCT
fnp-2671	100	11	irradiation	irradiation	NOUN
fnp-2671	100	12	)	)	PUNCT
fnp-2671	100	13	generally	generally	ADV
fnp-2671	100	14	did	do	AUX
fnp-2671	100	15	not	not	PART
fnp-2671	100	16	seem	seem	VERB
fnp-2671	100	17	to	to	PART
fnp-2671	100	18	coerce	coerce	VERB
fnp-2671	100	19	the	the	DET
fnp-2671	100	20	tumors	tumor	NOUN
fnp-2671	100	21	down	down	ADP
fnp-2671	100	22	predictable	predictable	ADJ
fnp-2671	100	23	paths	path	NOUN
fnp-2671	100	24	.	.	PUNCT
fnp-2671	101	1	idh	idh	NOUN
fnp-2671	101	2	-	-	PUNCT
fnp-2671	101	3	mutant	mutant	NOUN
fnp-2671	101	4	-	-	PUNCT
fnp-2671	101	5	noncodels	noncodel	NOUN
fnp-2671	101	6	were	be	AUX
fnp-2671	101	7	found	find	VERB
fnp-2671	101	8	to	to	PART
fnp-2671	101	9	be	be	AUX
fnp-2671	101	10	most	most	ADV
fnp-2671	101	11	sensitive	sensitive	ADJ
fnp-2671	101	12	to	to	ADP
fnp-2671	101	13	developing	develop	VERB
fnp-2671	101	14	a	a	DET
fnp-2671	101	15	hypermutator	hypermutator	NOUN
fnp-2671	101	16	phenotype	phenotype	NOUN
fnp-2671	101	17	after	after	ADP
fnp-2671	101	18	therapy	therapy	NOUN
fnp-2671	101	19	with	with	ADP
fnp-2671	101	20	alkylating	alkylate	VERB
fnp-2671	101	21	agents	agent	NOUN
fnp-2671	101	22	,	,	PUNCT
fnp-2671	101	23	a	a	DET
fnp-2671	101	24	phenomenon	phenomenon	NOUN
fnp-2671	101	25	that	that	PRON
fnp-2671	101	26	has	have	AUX
fnp-2671	101	27	been	be	AUX
fnp-2671	101	28	reported	report	VERB
fnp-2671	101	29	before	before	ADP
fnp-2671	101	30	[	[	X
fnp-2671	101	31	38	38	NUM
fnp-2671	101	32	,	,	PUNCT
fnp-2671	101	33	39	39	NUM
fnp-2671	101	34	]	]	PUNCT
fnp-2671	101	35	.	.	PUNCT
fnp-2671	102	1	importantly	importantly	ADV
fnp-2671	102	2	,	,	PUNCT
fnp-2671	102	3	no	no	DET
fnp-2671	102	4	differences	difference	NOUN
fnp-2671	102	5	were	be	AUX
fnp-2671	102	6	found	find	VERB
fnp-2671	102	7	in	in	ADP
fnp-2671	102	8	overall	overall	ADJ
fnp-2671	102	9	survival	survival	NOUN
fnp-2671	102	10	between	between	ADP
fnp-2671	102	11	hypermutators	hypermutator	NOUN
fnp-2671	102	12	and	and	CCONJ
fnp-2671	102	13	non	non	ADJ
fnp-2671	102	14	-	-	ADJ
fnp-2671	102	15	hypermutators	hypermutator	NOUN
fnp-2671	102	16	independent	independent	ADJ
fnp-2671	102	17	of	of	ADP
fnp-2671	102	18	age	age	NOUN
fnp-2671	102	19	,	,	PUNCT
fnp-2671	102	20	subtype	subtype	NOUN
fnp-2671	102	21	and	and	CCONJ
fnp-2671	102	22	mgmt	mgmt	NOUN
fnp-2671	102	23	promoter	promoter	NOUN
fnp-2671	102	24	methylation	methylation	NOUN
fnp-2671	102	25	status	status	NOUN
fnp-2671	102	26	.	.	PUNCT
fnp-2671	103	1	in	in	ADP
fnp-2671	103	2	line	line	NOUN
fnp-2671	103	3	with	with	ADP
fnp-2671	103	4	a	a	DET
fnp-2671	103	5	recent	recent	ADJ
fnp-2671	103	6	study	study	NOUN
fnp-2671	103	7	demonstrating	demonstrate	VERB
fnp-2671	103	8	that	that	SCONJ
fnp-2671	103	9	homozygous	homozygous	ADJ
fnp-2671	103	10	cdkn2a	cdkn2a	PROPN
fnp-2671	103	11	loss	loss	NOUN
fnp-2671	103	12	is	be	AUX
fnp-2671	103	13	a	a	DET
fnp-2671	103	14	marker	marker	NOUN
fnp-2671	103	15	for	for	ADP
fnp-2671	103	16	high	high	ADJ
fnp-2671	103	17	-	-	PUNCT
fnp-2671	103	18	grade	grade	NOUN
fnp-2671	103	19	malignancy	malignancy	NOUN
fnp-2671	103	20	in	in	ADP
fnp-2671	103	21	idh	idh	NOUN
fnp-2671	103	22	-	-	PUNCT
fnp-2671	103	23	mutant	mutant	NOUN
fnp-2671	103	24	-	-	PUNCT
fnp-2671	103	25	noncodels	noncodel	NOUN
fnp-2671	103	26	[	[	X
fnp-2671	103	27	40	40	NUM
fnp-2671	103	28	]	]	PUNCT
fnp-2671	103	29	,	,	PUNCT
fnp-2671	103	30	in	in	ADP
fnp-2671	103	31	the	the	DET
fnp-2671	103	32	glass	glass	NOUN
fnp-2671	103	33	study	study	NOUN
fnp-2671	103	34	recurrent	recurrent	NOUN
fnp-2671	103	35	idh	idh	NOUN
fnp-2671	103	36	-	-	PUNCT
fnp-2671	103	37	mutant	mutant	NOUN
fnp-2671	103	38	-	-	PUNCT
fnp-2671	103	39	noncodels	noncodel	NOUN
fnp-2671	103	40	were	be	AUX
fnp-2671	103	41	enriched	enrich	VERB
fnp-2671	103	42	for	for	ADP
fnp-2671	103	43	homozygous	homozygous	ADJ
fnp-2671	103	44	cdkn2a	cdkn2a	ADJ
fnp-2671	103	45	deletions	deletion	NOUN
fnp-2671	103	46	and	and	CCONJ
fnp-2671	103	47	this	this	PRON
fnp-2671	103	48	was	be	AUX
fnp-2671	103	49	associated	associate	VERB
fnp-2671	103	50	with	with	ADP
fnp-2671	103	51	shorter	short	ADJ
fnp-2671	103	52	survival	survival	NOUN
fnp-2671	103	53	compared	compare	VERB
fnp-2671	103	54	to	to	ADP
fnp-2671	103	55	patients	patient	NOUN
fnp-2671	103	56	without	without	ADP
fnp-2671	103	57	these	these	DET
fnp-2671	103	58	alterations	alteration	NOUN
fnp-2671	103	59	.	.	PUNCT
fnp-2671	104	1	no	no	DET
fnp-2671	104	2	differences	difference	NOUN
fnp-2671	104	3	in	in	ADP
fnp-2671	104	4	the	the	DET
fnp-2671	104	5	levels	level	NOUN
fnp-2671	104	6	of	of	ADP
fnp-2671	104	7	immunoediting	immunoediting	NOUN
fnp-2671	104	8	were	be	AUX
fnp-2671	104	9	found	find	VERB
fnp-2671	104	10	between	between	ADP
fnp-2671	104	11	initial	initial	ADJ
fnp-2671	104	12	and	and	CCONJ
fnp-2671	104	13	recurrent	recurrent	ADJ
fnp-2671	104	14	gliomas	glioma	NOUN
fnp-2671	104	15	.	.	PUNCT
fnp-2671	105	1	the	the	DET
fnp-2671	105	2	glass	glass	NOUN
fnp-2671	105	3	study	study	NOUN
fnp-2671	105	4	thus	thus	ADV
fnp-2671	105	5	indicates	indicate	VERB
fnp-2671	105	6	that	that	SCONJ
fnp-2671	105	7	the	the	DET
fnp-2671	105	8	strongest	strong	ADJ
fnp-2671	105	9	selective	selective	ADJ
fnp-2671	105	10	pressure	pressure	NOUN
fnp-2671	105	11	in	in	ADP
fnp-2671	105	12	these	these	DET
fnp-2671	105	13	three	three	NUM
fnp-2671	105	14	major	major	ADJ
fnp-2671	105	15	subgroups	subgroup	NOUN
fnp-2671	105	16	of	of	ADP
fnp-2671	105	17	diffuse	diffuse	PROPN
fnp-2671	105	18	gliomas	glioma	NOUN
fnp-2671	105	19	occurs	occur	VERB
fnp-2671	105	20	during	during	ADP
fnp-2671	105	21	early	early	ADJ
fnp-2671	105	22	glioma	glioma	NOUN
fnp-2671	105	23	development	development	NOUN
fnp-2671	105	24	and	and	CCONJ
fnp-2671	105	25	that	that	SCONJ
fnp-2671	105	26	current	current	ADJ
fnp-2671	105	27	therapies	therapy	NOUN
fnp-2671	105	28	shape	shape	VERB
fnp-2671	105	29	this	this	DET
fnp-2671	105	30	evolution	evolution	NOUN
fnp-2671	105	31	in	in	ADP
fnp-2671	105	32	a	a	DET
fnp-2671	105	33	largely	largely	ADV
fnp-2671	105	34	stochastic	stochastic	ADJ
fnp-2671	105	35	manner	manner	NOUN
fnp-2671	105	36	.	.	PUNCT
fnp-2671	106	1	hopefully	hopefully	ADV
fnp-2671	106	2	,	,	PUNCT
fnp-2671	106	3	such	such	ADJ
fnp-2671	106	4	information	information	NOUN
fnp-2671	106	5	on	on	ADP
fnp-2671	106	6	how	how	SCONJ
fnp-2671	106	7	diffuse	diffuse	ADJ
fnp-2671	106	8	gliomas	glioma	NOUN
fnp-2671	106	9	evolve	evolve	VERB
fnp-2671	106	10	over	over	ADP
fnp-2671	106	11	time	time	NOUN
fnp-2671	106	12	and	and	CCONJ
fnp-2671	106	13	in	in	ADP
fnp-2671	106	14	response	response	NOUN
fnp-2671	106	15	to	to	ADP
fnp-2671	106	16	therapy	therapy	NOUN
fnp-2671	106	17	will	will	AUX
fnp-2671	106	18	help	help	VERB
fnp-2671	106	19	to	to	PART
fnp-2671	106	20	design	design	VERB
fnp-2671	106	21	more	more	ADV
fnp-2671	106	22	efficacious	efficacious	ADJ
fnp-2671	106	23	therapeutic	therapeutic	ADJ
fnp-2671	106	24	strategies	strategy	NOUN
fnp-2671	106	25	for	for	ADP
fnp-2671	106	26	these	these	DET
fnp-2671	106	27	tumors	tumor	NOUN
fnp-2671	106	28	.	.	PUNCT
fnp-2671	107	1	topic	topic	NOUN
fnp-2671	107	2	6	6	NUM
fnp-2671	107	3	.	.	PUNCT
fnp-2671	108	1	notch1	notch1	NOUN
fnp-2671	108	2	-	-	PUNCT
fnp-2671	108	3	sox2	sox2	NOUN
fnp-2671	108	4	signaling	signal	VERB
fnp-2671	108	5	controls	control	NOUN
fnp-2671	108	6	glioma	glioma	NOUN
fnp-2671	108	7	cell	cell	NOUN
fnp-2671	108	8	invasion	invasion	NOUN
fnp-2671	108	9	in	in	ADP
fnp-2671	108	10	white	white	ADJ
fnp-2671	108	11	matter	matter	NOUN
fnp-2671	108	12	tracts	tract	NOUN
fnp-2671	108	13	[	[	X
fnp-2671	108	14	9	9	NUM
fnp-2671	108	15	]	]	PUNCT
fnp-2671	108	16	one	one	NUM
fnp-2671	108	17	of	of	ADP
fnp-2671	108	18	the	the	DET
fnp-2671	108	19	main	main	ADJ
fnp-2671	108	20	reasons	reason	NOUN
fnp-2671	108	21	that	that	PRON
fnp-2671	108	22	patients	patient	NOUN
fnp-2671	108	23	with	with	ADP
fnp-2671	108	24	diffuse	diffuse	ADJ
fnp-2671	108	25	gliomas	glioma	NOUN
fnp-2671	108	26	so	so	ADV
fnp-2671	108	27	far	far	ADV
fnp-2671	108	28	can	can	AUX
fnp-2671	108	29	not	not	PART
fnp-2671	108	30	be	be	AUX
fnp-2671	108	31	cured	cure	VERB
fnp-2671	108	32	is	be	AUX
fnp-2671	108	33	the	the	DET
fnp-2671	108	34	diffuse	diffuse	ADJ
fnp-2671	108	35	infiltrative	infiltrative	ADJ
fnp-2671	108	36	growth	growth	NOUN
fnp-2671	108	37	of	of	ADP
fnp-2671	108	38	the	the	DET
fnp-2671	108	39	tumor	tumor	NOUN
fnp-2671	108	40	cells	cell	NOUN
fnp-2671	108	41	along	along	ADP
fnp-2671	108	42	white	white	ADJ
fnp-2671	108	43	matter	matter	NOUN
fnp-2671	108	44	tracts	tract	NOUN
fnp-2671	108	45	.	.	PUNCT
fnp-2671	109	1	one	one	PRON
fnp-2671	109	2	would	would	AUX
fnp-2671	109	3	hope	hope	VERB
fnp-2671	109	4	that	that	SCONJ
fnp-2671	109	5	unraveling	unravel	VERB
fnp-2671	109	6	the	the	DET
fnp-2671	109	7	mechanisms	mechanism	NOUN
fnp-2671	109	8	underlying	underlie	VERB
fnp-2671	109	9	this	this	DET
fnp-2671	109	10	phenomenon	phenomenon	NOUN
fnp-2671	109	11	may	may	AUX
fnp-2671	109	12	help	help	VERB
fnp-2671	109	13	to	to	PART
fnp-2671	109	14	identify	identify	VERB
fnp-2671	109	15	novel	novel	ADJ
fnp-2671	109	16	therapeutic	therapeutic	ADJ
fnp-2671	109	17	targets	target	NOUN
fnp-2671	109	18	.	.	PUNCT
fnp-2671	110	1	in	in	ADP
fnp-2671	110	2	an	an	DET
fnp-2671	110	3	analysis	analysis	NOUN
fnp-2671	110	4	of	of	ADP
fnp-2671	110	5	human	human	ADJ
fnp-2671	110	6	glioma	glioma	NOUN
fnp-2671	110	7	tissue	tissue	NOUN
fnp-2671	110	8	samples	sample	NOUN
fnp-2671	110	9	,	,	PUNCT
fnp-2671	110	10	wang	wang	PROPN
fnp-2671	110	11	et	et	PROPN
fnp-2671	110	12	al	al	PROPN
fnp-2671	110	13	found	find	VERB
fnp-2671	110	14	that	that	SCONJ
fnp-2671	110	15	at	at	ADP
fnp-2671	110	16	the	the	DET
fnp-2671	110	17	invasive	invasive	ADJ
fnp-2671	110	18	front	front	NOUN
fnp-2671	110	19	,	,	PUNCT
fnp-2671	110	20	cd133	cd133	PROPN
fnp-2671	110	21	+	+	CCONJ
fnp-2671	110	22	‘	'	PUNCT
fnp-2671	110	23	glioma	glioma	NOUN
fnp-2671	110	24	stem	stem	NOUN
fnp-2671	110	25	cells	cell	NOUN
fnp-2671	110	26	’	'	PUNCT
fnp-2671	110	27	(	(	PUNCT
fnp-2671	110	28	gscs	gsc	NOUN
fnp-2671	110	29	)	)	PUNCT
fnp-2671	110	30	were	be	AUX
fnp-2671	110	31	preferentially	preferentially	ADV
fnp-2671	110	32	located	locate	VERB
fnp-2671	110	33	along	along	ADP
fnp-2671	110	34	white	white	ADJ
fnp-2671	110	35	matter	matter	NOUN
fnp-2671	110	36	tracts	tract	NOUN
fnp-2671	110	37	[	[	X
fnp-2671	110	38	41	41	NUM
fnp-2671	110	39	]	]	PUNCT
fnp-2671	110	40	.	.	PUNCT
fnp-2671	111	1	also	also	ADV
fnp-2671	111	2	,	,	PUNCT
fnp-2671	111	3	these	these	DET
fnp-2671	111	4	tracts	tract	NOUN
fnp-2671	111	5	showed	show	VERB
fnp-2671	111	6	significant	significant	ADJ
fnp-2671	111	7	swelling	swelling	NOUN
fnp-2671	111	8	and	and	CCONJ
fnp-2671	111	9	seemed	seem	VERB
fnp-2671	111	10	to	to	PART
fnp-2671	111	11	have	have	VERB
fnp-2671	111	12	discontinuous	discontinuous	ADJ
fnp-2671	111	13	myelin	myelin	NOUN
fnp-2671	111	14	,	,	PUNCT
fnp-2671	111	15	indicating	indicate	VERB
fnp-2671	111	16	that	that	SCONJ
fnp-2671	111	17	some	some	DET
fnp-2671	111	18	gscs	gsc	NOUN
fnp-2671	111	19	in	in	ADP
fnp-2671	111	20	the	the	DET
fnp-2671	111	21	glioma	glioma	NOUN
fnp-2671	111	22	-	-	PUNCT
fnp-2671	111	23	brain	brain	NOUN
fnp-2671	111	24	interface	interface	NOUN
fnp-2671	111	25	are	be	AUX
fnp-2671	111	26	preferentially	preferentially	ADV
fnp-2671	111	27	located	locate	VERB
fnp-2671	111	28	adjacent	adjacent	ADJ
fnp-2671	111	29	to	to	ADP
fnp-2671	111	30	unmyelinated	unmyelinated	ADJ
fnp-2671	111	31	white	white	ADJ
fnp-2671	111	32	matter	matter	NOUN
fnp-2671	111	33	tracts	tract	NOUN
fnp-2671	111	34	.	.	PUNCT
fnp-2671	112	1	based	base	VERB
fnp-2671	112	2	on	on	ADP
fnp-2671	112	3	their	their	PRON
fnp-2671	112	4	findings	finding	NOUN
fnp-2671	112	5	the	the	DET
fnp-2671	112	6	authors	author	NOUN
fnp-2671	112	7	postulate	postulate	VERB
fnp-2671	112	8	that	that	DET
fnp-2671	112	9	glioma	glioma	NOUN
fnp-2671	112	10	invasion	invasion	NOUN
fnp-2671	112	11	along	along	ADP
fnp-2671	112	12	these	these	DET
fnp-2671	112	13	tracts	tract	NOUN
fnp-2671	112	14	occurs	occur	VERB
fnp-2671	112	15	along	along	ADP
fnp-2671	112	16	axons	axon	NOUN
fnp-2671	112	17	inside	inside	ADP
fnp-2671	112	18	myelin	myelin	NOUN
fnp-2671	112	19	sheaths	sheath	NOUN
fnp-2671	112	20	rather	rather	ADV
fnp-2671	112	21	than	than	ADP
fnp-2671	112	22	along	along	ADP
fnp-2671	112	23	the	the	DET
fnp-2671	112	24	outer	outer	ADJ
fnp-2671	112	25	surface	surface	NOUN
fnp-2671	112	26	of	of	ADP
fnp-2671	112	27	such	such	ADJ
fnp-2671	112	28	sheaths	sheath	NOUN
fnp-2671	112	29	,	,	PUNCT
fnp-2671	112	30	and	and	CCONJ
fnp-2671	112	31	that	that	SCONJ
fnp-2671	112	32	glioma	glioma	NOUN
fnp-2671	112	33	-	-	PUNCT
fnp-2671	112	34	associated	associate	VERB
fnp-2671	112	35	edema	edema	NOUN
fnp-2671	112	36	may	may	AUX
fnp-2671	112	37	play	play	VERB
fnp-2671	112	38	a	a	DET
fnp-2671	112	39	role	role	NOUN
fnp-2671	112	40	in	in	ADP
fnp-2671	112	41	local	local	ADJ
fnp-2671	112	42	destruction	destruction	NOUN
fnp-2671	112	43	of	of	ADP
fnp-2671	112	44	white	white	ADJ
fnp-2671	112	45	matter	matter	NOUN
fnp-2671	112	46	fibers	fiber	NOUN
fnp-2671	112	47	and	and	CCONJ
fnp-2671	112	48	thereby	thereby	ADV
fnp-2671	112	49	pave	pave	VERB
fnp-2671	112	50	the	the	DET
fnp-2671	112	51	way	way	NOUN
fnp-2671	112	52	for	for	ADP
fnp-2671	112	53	direct	direct	ADJ
fnp-2671	112	54	interaction	interaction	NOUN
fnp-2671	112	55	of	of	ADP
fnp-2671	112	56	glioma	glioma	NOUN
fnp-2671	112	57	cells	cell	NOUN
fnp-2671	112	58	and	and	CCONJ
fnp-2671	112	59	axons	axon	NOUN
fnp-2671	112	60	.	.	PUNCT
fnp-2671	113	1	additionally	additionally	ADV
fnp-2671	113	2	,	,	PUNCT
fnp-2671	113	3	based	base	VERB
fnp-2671	113	4	on	on	ADP
fnp-2671	113	5	their	their	PRON
fnp-2671	113	6	findings	finding	NOUN
fnp-2671	113	7	in	in	ADP
fnp-2671	113	8	preclinical	preclinical	ADJ
fnp-2671	113	9	experiments	experiment	NOUN
fnp-2671	113	10	that	that	SCONJ
fnp-2671	113	11	nearly	nearly	ADV
fnp-2671	113	12	all	all	PRON
fnp-2671	113	13	cd133	cd133	NOUN
fnp-2671	113	14	+	+	NUM
fnp-2671	113	15	gscs	gsc	NOUN
fnp-2671	113	16	were	be	AUX
fnp-2671	113	17	also	also	ADV
fnp-2671	113	18	notch1	notch1	NOUN
fnp-2671	113	19	+	+	X
fnp-2671	113	20	and	and	CCONJ
fnp-2671	113	21	that	that	SCONJ
fnp-2671	113	22	nerve	nerve	NOUN
fnp-2671	113	23	fibers	fiber	NOUN
fnp-2671	113	24	at	at	ADP
fnp-2671	113	25	the	the	DET
fnp-2671	113	26	invasive	invasive	ADJ
fnp-2671	113	27	frontier	frontier	NOUN
fnp-2671	113	28	all	all	PRON
fnp-2671	113	29	expressed	express	VERB
fnp-2671	113	30	jagged1	jagged1	NOUN
fnp-2671	113	31	,	,	PUNCT
fnp-2671	113	32	wang	wang	PROPN
fnp-2671	113	33	et	et	PROPN
fnp-2671	113	34	al	al	PROPN
fnp-2671	113	35	postulate	postulate	VERB
fnp-2671	113	36	that	that	SCONJ
fnp-2671	113	37	the	the	DET
fnp-2671	113	38	interaction	interaction	NOUN
fnp-2671	113	39	between	between	ADP
fnp-2671	113	40	jagged1	jagged1	NOUN
fnp-2671	113	41	and	and	CCONJ
fnp-2671	113	42	notch1	notch1	NOUN
fnp-2671	113	43	may	may	AUX
fnp-2671	113	44	be	be	AUX
fnp-2671	113	45	an	an	DET
fnp-2671	113	46	important	important	ADJ
fnp-2671	113	47	determinant	determinant	ADJ
fnp-2671	113	48	for	for	ADP
fnp-2671	113	49	the	the	DET
fnp-2671	113	50	distribution	distribution	NOUN
fnp-2671	113	51	of	of	ADP
fnp-2671	113	52	gscs	gsc	NOUN
fnp-2671	113	53	.	.	PUNCT
fnp-2671	114	1	indeed	indeed	ADV
fnp-2671	114	2	,	,	PUNCT
fnp-2671	114	3	axonally	axonally	ADV
fnp-2671	114	4	expressed	express	VERB
fnp-2671	114	5	jagged1	jagged1	NOUN
fnp-2671	114	6	was	be	AUX
fnp-2671	114	7	found	find	VERB
fnp-2671	114	8	to	to	PART
fnp-2671	114	9	activate	activate	VERB
fnp-2671	114	10	the	the	DET
fnp-2671	114	11	notch	notch	NOUN
fnp-2671	114	12	signaling	signal	VERB
fnp-2671	114	13	pathway	pathway	NOUN
fnp-2671	114	14	in	in	ADP
fnp-2671	114	15	gscs	gsc	NOUN
fnp-2671	114	16	and	and	CCONJ
fnp-2671	114	17	to	to	PART
fnp-2671	114	18	subsequently	subsequently	ADV
fnp-2671	114	19	promote	promote	VERB
fnp-2671	114	20	the	the	DET
fnp-2671	114	21	transcription	transcription	NOUN
fnp-2671	114	22	of	of	ADP
fnp-2671	114	23	sox2	sox2	NOUN
fnp-2671	114	24	via	via	ADP
fnp-2671	114	25	sox9	sox9	PROPN
fnp-2671	114	26	.	.	PUNCT
fnp-2671	115	1	conversely	conversely	ADV
fnp-2671	115	2	,	,	PUNCT
fnp-2671	115	3	sox2	sox2	NOUN
fnp-2671	115	4	upregulation	upregulation	NOUN
fnp-2671	115	5	decreased	decrease	VERB
fnp-2671	115	6	the	the	DET
fnp-2671	115	7	methylation	methylation	NOUN
fnp-2671	115	8	of	of	ADP
fnp-2671	115	9	the	the	DET
fnp-2671	115	10	notch1	notch1	NOUN
fnp-2671	115	11	promoter	promoter	NOUN
fnp-2671	115	12	to	to	PART
fnp-2671	115	13	reinforce	reinforce	VERB
fnp-2671	115	14	the	the	DET
fnp-2671	115	15	high	high	ADJ
fnp-2671	115	16	expression	expression	NOUN
fnp-2671	115	17	of	of	ADP
fnp-2671	115	18	notch1	notch1	NOUN
fnp-2671	115	19	in	in	ADP
fnp-2671	115	20	gscs	gsc	NOUN
fnp-2671	115	21	and	and	CCONJ
fnp-2671	115	22	facilitate	facilitate	VERB
fnp-2671	115	23	their	their	PRON
fnp-2671	115	24	white	white	ADJ
fnp-2671	115	25	matter	matter	NOUN
fnp-2671	115	26	-	-	PUNCT
fnp-2671	115	27	tract	tract	NOUN
fnp-2671	115	28	tropism	tropism	NOUN
fnp-2671	115	29	,	,	PUNCT
fnp-2671	115	30	while	while	SCONJ
fnp-2671	115	31	inhibition	inhibition	NOUN
fnp-2671	115	32	of	of	ADP
fnp-2671	115	33	notch	notch	ADJ
fnp-2671	115	34	signaling	signal	VERB
fnp-2671	115	35	was	be	AUX
fnp-2671	115	36	found	find	VERB
fnp-2671	115	37	to	to	PART
fnp-2671	115	38	attenuate	attenuate	VERB
fnp-2671	115	39	this	this	DET
fnp-2671	115	40	tropism	tropism	NOUN
fnp-2671	115	41	.	.	PUNCT
fnp-2671	116	1	the	the	DET
fnp-2671	116	2	findings	finding	NOUN
fnp-2671	116	3	of	of	ADP
fnp-2671	116	4	wang	wang	PROPN
fnp-2671	116	5	et	et	PROPN
fnp-2671	116	6	al	al	PROPN
fnp-2671	116	7	indicate	indicate	VERB
fnp-2671	116	8	that	that	SCONJ
fnp-2671	116	9	the	the	DET
fnp-2671	116	10	notch1	notch1	NOUN
fnp-2671	116	11	-	-	PUNCT
fnp-2671	116	12	sox2	sox2	ADJ
fnp-2671	116	13	positive	positive	ADJ
fnp-2671	116	14	-	-	PUNCT
fnp-2671	116	15	feedback	feedback	NOUN
fnp-2671	116	16	loop	loop	NOUN
fnp-2671	116	17	is	be	AUX
fnp-2671	116	18	an	an	DET
fnp-2671	116	19	important	important	ADJ
fnp-2671	116	20	determinant	determinant	NOUN
fnp-2671	116	21	of	of	ADP
fnp-2671	116	22	gsc	gsc	PROPN
fnp-2671	116	23	invasion	invasion	NOUN
fnp-2671	116	24	along	along	ADP
fnp-2671	116	25	white	white	ADJ
fnp-2671	116	26	matter	matter	NOUN
fnp-2671	116	27	tracts	tract	NOUN
fnp-2671	116	28	,	,	PUNCT
fnp-2671	116	29	and	and	CCONJ
fnp-2671	116	30	that	that	SCONJ
fnp-2671	116	31	molecules	molecule	NOUN
fnp-2671	116	32	in	in	ADP
fnp-2671	116	33	this	this	DET
fnp-2671	116	34	loop	loop	NOUN
fnp-2671	116	35	may	may	AUX
fnp-2671	116	36	be	be	AUX
fnp-2671	116	37	exploited	exploit	VERB
fnp-2671	116	38	as	as	ADP
fnp-2671	116	39	therapeutic	therapeutic	ADJ
fnp-2671	116	40	targets	target	NOUN
fnp-2671	116	41	.	.	PUNCT
fnp-2671	117	1	however	however	ADV
fnp-2671	117	2	,	,	PUNCT
fnp-2671	117	3	the	the	DET
fnp-2671	117	4	authors	author	NOUN
fnp-2671	117	5	acknowledge	acknowledge	VERB
fnp-2671	117	6	that	that	SCONJ
fnp-2671	117	7	the	the	DET
fnp-2671	117	8	mechanisms	mechanism	NOUN
fnp-2671	117	9	underlying	underlie	VERB
fnp-2671	117	10	glioma	glioma	NOUN
fnp-2671	117	11	cell	cell	NOUN
fnp-2671	117	12	invasion	invasion	NOUN
fnp-2671	117	13	along	along	ADP
fnp-2671	117	14	white	white	ADJ
fnp-2671	117	15	matter	matter	NOUN
fnp-2671	117	16	tracts	tract	NOUN
fnp-2671	117	17	are	be	AUX
fnp-2671	117	18	probably	probably	ADV
fnp-2671	117	19	more	more	ADV
fnp-2671	117	20	complex	complex	ADJ
fnp-2671	117	21	,	,	PUNCT
fnp-2671	117	22	and	and	CCONJ
fnp-2671	117	23	may	may	AUX
fnp-2671	117	24	also	also	ADV
fnp-2671	117	25	involve	involve	VERB
fnp-2671	117	26	mechanisms	mechanism	NOUN
fnp-2671	117	27	as	as	SCONJ
fnp-2671	117	28	discussed	discuss	VERB
fnp-2671	117	29	in	in	ADP
fnp-2671	117	30	the	the	DET
fnp-2671	117	31	next	next	ADJ
fnp-2671	117	32	topic	topic	NOUN
fnp-2671	117	33	(	(	PUNCT
fnp-2671	117	34	topic	topic	NOUN
fnp-2671	117	35	7	7	NUM
fnp-2671	117	36	)	)	PUNCT
fnp-2671	117	37	.	.	PUNCT
fnp-2671	118	1	topic	topic	NOUN
fnp-2671	118	2	7	7	NUM
fnp-2671	118	3	.	.	PUNCT
fnp-2671	119	1	‘	'	PUNCT
fnp-2671	119	2	synaptic	synaptic	ADJ
fnp-2671	119	3	cooption	cooption	NOUN
fnp-2671	119	4	’	'	PUNCT
fnp-2671	119	5	in	in	ADP
fnp-2671	119	6	glial	glial	ADJ
fnp-2671	119	7	and	and	CCONJ
fnp-2671	119	8	metastatic	metastatic	ADJ
fnp-2671	119	9	cns	cns	NOUN
fnp-2671	119	10	tumors	tumor	NOUN
fnp-2671	120	1	[	[	X
fnp-2671	120	2	10	10	NUM
fnp-2671	120	3	-	-	SYM
fnp-2671	120	4	12	12	NUM
fnp-2671	120	5	]	]	PUNCT
fnp-2671	120	6	after	after	ADP
fnp-2671	120	7	reporting	report	VERB
fnp-2671	120	8	earlier	early	ADV
fnp-2671	120	9	that	that	SCONJ
fnp-2671	120	10	neuroligin-3	neuroligin-3	PRON
fnp-2671	120	11	secreted	secrete	VERB
fnp-2671	120	12	by	by	ADP
fnp-2671	120	13	active	active	ADJ
fnp-2671	120	14	neurons	neuron	NOUN
fnp-2671	120	15	promotes	promote	VERB
fnp-2671	120	16	glioma	glioma	ADJ
fnp-2671	120	17	growth	growth	NOUN
fnp-2671	120	18	[	[	X
fnp-2671	120	19	42	42	NUM
fnp-2671	120	20	,	,	PUNCT
fnp-2671	120	21	43	43	NUM
fnp-2671	120	22	]	]	PUNCT
fnp-2671	120	23	,	,	PUNCT
fnp-2671	120	24	in	in	ADP
fnp-2671	120	25	a	a	DET
fnp-2671	120	26	recent	recent	ADJ
fnp-2671	120	27	study	study	NOUN
fnp-2671	120	28	published	publish	VERB
fnp-2671	120	29	in	in	ADP
fnp-2671	120	30	nature	nature	NOUN
fnp-2671	120	31	,	,	PUNCT
fnp-2671	120	32	venkatesh	venkatesh	PROPN
fnp-2671	120	33	et	et	PROPN
fnp-2671	120	34	al	al	PROPN
fnp-2671	120	35	found	find	VERB
fnp-2671	120	36	that	that	SCONJ
fnp-2671	120	37	electrochemical	electrochemical	ADJ
fnp-2671	120	38	communication	communication	NOUN
fnp-2671	120	39	exists	exist	VERB
fnp-2671	120	40	between	between	ADP
fnp-2671	120	41	neurons	neuron	NOUN
fnp-2671	120	42	and	and	CCONJ
fnp-2671	120	43	glioma	glioma	NOUN
fnp-2671	120	44	cells	cell	NOUN
fnp-2671	120	45	through	through	ADP
fnp-2671	120	46	bona	bona	ADJ
fnp-2671	120	47	fide	fide	X
fnp-2671	120	48	ampa	ampa	NOUN
fnp-2671	120	49	(	(	PUNCT
fnp-2671	120	50	α	α	NOUN
fnp-2671	120	51	-	-	PUNCT
fnp-2671	120	52	amino-3	amino-3	ADJ
fnp-2671	120	53	-	-	PUNCT
fnp-2671	120	54	hydroxy-5	hydroxy-5	NUM
fnp-2671	120	55	-	-	PUNCT
fnp-2671	120	56	methyl-4	methyl-4	NOUN
fnp-2671	120	57	-	-	PUNCT
fnp-2671	120	58	isoxazolepropionic	isoxazolepropionic	NOUN
fnp-2671	120	59	acid	acid	NOUN
fnp-2671	120	60	)	)	PUNCT
fnp-2671	120	61	receptor	receptor	NOUN
fnp-2671	120	62	-	-	PUNCT
fnp-2671	120	63	dependent	dependent	ADJ
fnp-2671	120	64	synapses	synapsis	NOUN
fnp-2671	120	65	between	between	ADP
fnp-2671	120	66	these	these	DET
fnp-2671	120	67	cells	cell	NOUN
fnp-2671	120	68	[	[	X
fnp-2671	120	69	10	10	NUM
fnp-2671	120	70	]	]	PUNCT
fnp-2671	120	71	.	.	PUNCT
fnp-2671	121	1	also	also	ADV
fnp-2671	121	2	,	,	PUNCT
fnp-2671	121	3	neuronal	neuronal	ADJ
fnp-2671	121	4	activity	activity	NOUN
fnp-2671	121	5	was	be	AUX
fnp-2671	121	6	found	find	VERB
fnp-2671	121	7	to	to	PART
fnp-2671	121	8	evoke	evoke	VERB
fnp-2671	121	9	non	non	ADJ
fnp-2671	121	10	-	-	ADJ
fnp-2671	121	11	synaptic	synaptic	ADJ
fnp-2671	121	12	activity	activity	NOUN
fnp-2671	121	13	-	-	PUNCT
fnp-2671	121	14	dependent	dependent	ADJ
fnp-2671	121	15	potassium	potassium	NOUN
fnp-2671	121	16	currents	current	NOUN
fnp-2671	121	17	that	that	PRON
fnp-2671	121	18	were	be	AUX
fnp-2671	121	19	amplified	amplify	VERB
fnp-2671	121	20	by	by	ADP
fnp-2671	121	21	gap	gap	NOUN
fnp-2671	121	22	junction	junction	NOUN
fnp-2671	121	23	-	-	PUNCT
fnp-2671	121	24	mediated	mediate	VERB
fnp-2671	121	25	tumor	tumor	NOUN
fnp-2671	121	26	interconnections	interconnection	NOUN
fnp-2671	121	27	and	and	CCONJ
fnp-2671	121	28	resulting	result	VERB
fnp-2671	121	29	in	in	ADP
fnp-2671	121	30	an	an	DET
fnp-2671	121	31	electrically	electrically	ADV
fnp-2671	121	32	coupled	couple	VERB
fnp-2671	121	33	network	network	NOUN
fnp-2671	121	34	.	.	PUNCT
fnp-2671	122	1	depolarization	depolarization	NOUN
fnp-2671	122	2	of	of	ADP
fnp-2671	122	3	glioma	glioma	NOUN
fnp-2671	122	4	membranes	membrane	NOUN
fnp-2671	122	5	was	be	AUX
fnp-2671	122	6	found	find	VERB
fnp-2671	122	7	to	to	PART
fnp-2671	122	8	promote	promote	VERB
fnp-2671	122	9	proliferation	proliferation	NOUN
fnp-2671	122	10	,	,	PUNCT
fnp-2671	122	11	whereas	whereas	SCONJ
fnp-2671	122	12	blocking	block	VERB
fnp-2671	122	13	electrochemical	electrochemical	ADJ
fnp-2671	122	14	signaling	signaling	NOUN
fnp-2671	122	15	inhibited	inhibit	VERB
fnp-2671	122	16	the	the	DET
fnp-2671	122	17	growth	growth	NOUN
fnp-2671	122	18	of	of	ADP
fnp-2671	122	19	glioma	glioma	NOUN
fnp-2671	122	20	xenografts	xenograft	NOUN
fnp-2671	122	21	in	in	ADP
fnp-2671	122	22	mice	mouse	NOUN
fnp-2671	122	23	.	.	PUNCT
fnp-2671	123	1	intraoperative	intraoperative	ADJ
fnp-2671	123	2	electrocorticography	electrocorticography	NOUN
fnp-2671	123	3	in	in	ADP
fnp-2671	123	4	glioma	glioma	NOUN
fnp-2671	123	5	patients	patient	NOUN
fnp-2671	123	6	revealed	reveal	VERB
fnp-2671	123	7	increased	increase	VERB
fnp-2671	123	8	cortical	cortical	ADJ
fnp-2671	123	9	excitability	excitability	NOUN
fnp-2671	123	10	in	in	ADP
fnp-2671	123	11	the	the	DET
fnp-2671	123	12	glioma	glioma	NOUN
fnp-2671	123	13	-	-	PUNCT
fnp-2671	123	14	infiltrated	infiltrate	VERB
fnp-2671	123	15	brain	brain	NOUN
fnp-2671	123	16	areas	area	NOUN
fnp-2671	123	17	.	.	PUNCT
fnp-2671	124	1	based	base	VERB
fnp-2671	124	2	on	on	ADP
fnp-2671	124	3	these	these	DET
fnp-2671	124	4	findings	finding	NOUN
fnp-2671	124	5	the	the	DET
fnp-2671	124	6	authors	author	NOUN
fnp-2671	124	7	suggest	suggest	VERB
fnp-2671	124	8	that	that	SCONJ
fnp-2671	124	9	glioma	glioma	NOUN
fnp-2671	124	10	growth	growth	NOUN
fnp-2671	124	11	is	be	AUX
fnp-2671	124	12	promoted	promote	VERB
fnp-2671	124	13	by	by	ADP
fnp-2671	124	14	synaptic	synaptic	ADJ
fnp-2671	124	15	and	and	CCONJ
fnp-2671	124	16	electrical	electrical	ADJ
fnp-2671	124	17	integration	integration	NOUN
fnp-2671	124	18	into	into	ADP
fnp-2671	124	19	neural	neural	ADJ
fnp-2671	124	20	circuits	circuit	NOUN
fnp-2671	124	21	,	,	PUNCT
fnp-2671	124	22	with	with	ADP
fnp-2671	124	23	glioma	glioma	NOUN
fnp-2671	124	24	-	-	PUNCT
fnp-2671	124	25	induced	induce	VERB
fnp-2671	124	26	increase	increase	NOUN
fnp-2671	124	27	in	in	ADP
fnp-2671	124	28	neuronal	neuronal	ADJ
fnp-2671	124	29	excitability	excitability	NOUN
fnp-2671	124	30	and	and	CCONJ
fnp-2671	124	31	activity	activity	NOUN
fnp-2671	124	32	-	-	PUNCT
fnp-2671	124	33	regulated	regulate	VERB
fnp-2671	124	34	glioma	glioma	NOUN
fnp-2671	124	35	growth	growth	NOUN
fnp-2671	124	36	as	as	ADP
fnp-2671	124	37	elements	element	NOUN
fnp-2671	124	38	of	of	ADP
fnp-2671	124	39	a	a	DET
fnp-2671	124	40	positive	positive	ADJ
fnp-2671	124	41	feedback	feedback	NOUN
fnp-2671	124	42	loop	loop	NOUN
fnp-2671	124	43	.	.	PUNCT
fnp-2671	125	1	in	in	ADP
fnp-2671	125	2	the	the	DET
fnp-2671	125	3	same	same	ADJ
fnp-2671	125	4	issue	issue	NOUN
fnp-2671	125	5	of	of	ADP
fnp-2671	125	6	nature	nature	NOUN
fnp-2671	125	7	,	,	PUNCT
fnp-2671	125	8	venkaratamani	venkaratamani	PROPN
fnp-2671	125	9	et	et	PROPN
fnp-2671	125	10	al	al	PROPN
fnp-2671	125	11	also	also	ADV
fnp-2671	125	12	report	report	VERB
fnp-2671	125	13	that	that	SCONJ
fnp-2671	125	14	functional	functional	ADJ
fnp-2671	125	15	synapses	synapsis	NOUN
fnp-2671	125	16	between	between	ADP
fnp-2671	125	17	neurons	neuron	NOUN
fnp-2671	125	18	and	and	CCONJ
fnp-2671	125	19	glioma	glioma	NOUN
fnp-2671	125	20	cells	cell	NOUN
fnp-2671	125	21	exist	exist	VERB
fnp-2671	125	22	[	[	X
fnp-2671	125	23	11	11	NUM
fnp-2671	125	24	]	]	PUNCT
fnp-2671	125	25	.	.	PUNCT
fnp-2671	126	1	previously	previously	ADV
fnp-2671	126	2	,	,	PUNCT
fnp-2671	126	3	these	these	DET
fnp-2671	126	4	authors	author	NOUN
fnp-2671	126	5	already	already	ADV
fnp-2671	126	6	demonstrated	demonstrate	VERB
fnp-2671	126	7	that	that	SCONJ
fnp-2671	126	8	many	many	ADJ
fnp-2671	126	9	tumor	tumor	NOUN
fnp-2671	126	10	cells	cell	NOUN
fnp-2671	126	11	in	in	ADP
fnp-2671	126	12	astrocytic	astrocytic	ADJ
fnp-2671	126	13	tumors	tumor	NOUN
fnp-2671	126	14	including	include	VERB
fnp-2671	126	15	glioblastomas	glioblastoma	NOUN
fnp-2671	126	16	extend	extend	VERB
fnp-2671	126	17	ultra	ultra	ADJ
fnp-2671	126	18	-	-	ADJ
fnp-2671	126	19	long	long	ADJ
fnp-2671	126	20	membrane	membrane	NOUN
fnp-2671	126	21	protrusions	protrusion	NOUN
fnp-2671	126	22	(	(	PUNCT
fnp-2671	126	23	microtubes	microtube	NOUN
fnp-2671	126	24	)	)	PUNCT
fnp-2671	126	25	that	that	PRON
fnp-2671	126	26	are	be	AUX
fnp-2671	126	27	used	use	VERB
fnp-2671	126	28	for	for	ADP
fnp-2671	126	29	brain	brain	NOUN
fnp-2671	126	30	invasion	invasion	NOUN
fnp-2671	126	31	and	and	CCONJ
fnp-2671	126	32	proliferation	proliferation	NOUN
fnp-2671	126	33	,	,	PUNCT
fnp-2671	126	34	and	and	CCONJ
fnp-2671	126	35	that	that	DET
fnp-2671	126	36	interconnect	interconnect	NOUN
fnp-2671	126	37	over	over	ADP
fnp-2671	126	38	long	long	ADJ
fnp-2671	126	39	distances	distance	NOUN
fnp-2671	126	40	[	[	X
fnp-2671	126	41	44	44	NUM
fnp-2671	126	42	]	]	PUNCT
fnp-2671	126	43	(	(	PUNCT
fnp-2671	126	44	fig	fig	NOUN
fnp-2671	126	45	.	.	PUNCT
fnp-2671	126	46	2	2	NUM
fnp-2671	126	47	)	)	PUNCT
fnp-2671	126	48	.	.	PUNCT
fnp-2671	127	1	in	in	ADP
fnp-2671	127	2	their	their	PRON
fnp-2671	127	3	recent	recent	ADJ
fnp-2671	127	4	study	study	NOUN
fnp-2671	127	5	,	,	PUNCT
fnp-2671	127	6	venkaratamani	venkaratamani	PROPN
fnp-2671	127	7	et	et	PROPN
fnp-2671	127	8	al	al	PROPN
fnp-2671	127	9	show	show	VERB
fnp-2671	127	10	the	the	DET
fnp-2671	127	11	presence	presence	NOUN
fnp-2671	127	12	of	of	ADP
fnp-2671	127	13	‘	'	PUNCT
fnp-2671	127	14	neurogliomal	neurogliomal	ADJ
fnp-2671	127	15	synapses	synapsis	NOUN
fnp-2671	127	16	’	'	PUNCT
fnp-2671	127	17	in	in	ADP
fnp-2671	127	18	human	human	ADJ
fnp-2671	127	19	glioma	glioma	NOUN
fnp-2671	127	20	samples	sample	NOUN
fnp-2671	127	21	and	and	CCONJ
fnp-2671	127	22	in	in	ADP
fnp-2671	127	23	different	different	ADJ
fnp-2671	127	24	disease	disease	NOUN
fnp-2671	127	25	models	model	NOUN
fnp-2671	127	26	.	.	PUNCT
fnp-2671	128	1	such	such	ADJ
fnp-2671	128	2	synapses	synapsis	NOUN
fnp-2671	128	3	were	be	AUX
fnp-2671	128	4	found	find	VERB
fnp-2671	128	5	to	to	PART
fnp-2671	128	6	be	be	AUX
fnp-2671	128	7	located	locate	VERB
fnp-2671	128	8	on	on	ADP
fnp-2671	128	9	tumor	tumor	NOUN
fnp-2671	128	10	microtubes	microtube	NOUN
fnp-2671	128	11	and	and	CCONJ
fnp-2671	128	12	produce	produce	VERB
fnp-2671	128	13	postsynaptic	postsynaptic	ADJ
fnp-2671	128	14	currents	current	NOUN
fnp-2671	128	15	that	that	PRON
fnp-2671	128	16	are	be	AUX
fnp-2671	128	17	mediated	mediate	VERB
fnp-2671	128	18	by	by	ADP
fnp-2671	128	19	glutamate	glutamate	ADJ
fnp-2671	128	20	receptors	receptor	NOUN
fnp-2671	128	21	of	of	ADP
fnp-2671	128	22	the	the	DET
fnp-2671	128	23	ampa	ampa	NOUN
fnp-2671	128	24	subtype	subtype	NOUN
fnp-2671	128	25	.	.	PUNCT
fnp-2671	129	1	in	in	ADP
fnp-2671	129	2	their	their	PRON
fnp-2671	129	3	experiments	experiment	NOUN
fnp-2671	129	4	,	,	PUNCT
fnp-2671	129	5	neuronal	neuronal	ADJ
fnp-2671	129	6	activity	activity	NOUN
fnp-2671	129	7	led	lead	VERB
fnp-2671	129	8	to	to	ADP
fnp-2671	129	9	synchronized	synchronize	VERB
fnp-2671	129	10	calcium	calcium	NOUN
fnp-2671	129	11	transients	transient	NOUN
fnp-2671	129	12	in	in	ADP
fnp-2671	129	13	tumor	tumor	NOUN
fnp-2671	129	14	-	-	PUNCT
fnp-2671	129	15	microtube	microtube	NOUN
fnp-2671	129	16	-	-	PUNCT
fnp-2671	129	17	connected	connect	VERB
fnp-2671	129	18	glioma	glioma	NOUN
fnp-2671	129	19	networks	network	NOUN
fnp-2671	129	20	.	.	PUNCT
fnp-2671	130	1	furthermore	furthermore	ADV
fnp-2671	130	2	,	,	PUNCT
fnp-2671	130	3	perturbation	perturbation	NOUN
fnp-2671	130	4	of	of	ADP
fnp-2671	130	5	ampa	ampa	NOUN
fnp-2671	130	6	receptors	receptor	NOUN
fnp-2671	130	7	and	and	CCONJ
fnp-2671	130	8	use	use	NOUN
fnp-2671	130	9	of	of	ADP
fnp-2671	130	10	an	an	DET
fnp-2671	130	11	ampa	ampa	NOUN
fnp-2671	130	12	receptor	receptor	NOUN
fnp-2671	130	13	antagonist	antagonist	NOUN
fnp-2671	130	14	reduced	reduce	VERB
fnp-2671	130	15	calcium	calcium	NOUN
fnp-2671	130	16	-	-	PUNCT
fnp-2671	130	17	related	relate	VERB
fnp-2671	130	18	invasiveness	invasiveness	NOUN
fnp-2671	130	19	of	of	ADP
fnp-2671	130	20	tumor	tumor	NOUN
fnp-2671	130	21	cells	cell	NOUN
fnp-2671	130	22	and	and	CCONJ
fnp-2671	130	23	of	of	ADP
fnp-2671	130	24	glioma	glioma	NOUN
fnp-2671	130	25	growth	growth	NOUN
fnp-2671	130	26	.	.	PUNCT
fnp-2671	131	1	intriguingly	intriguingly	ADV
fnp-2671	131	2	,	,	PUNCT
fnp-2671	131	3	in	in	ADP
fnp-2671	131	4	a	a	DET
fnp-2671	131	5	third	third	ADJ
fnp-2671	131	6	study	study	NOUN
fnp-2671	131	7	published	publish	VERB
fnp-2671	131	8	in	in	ADP
fnp-2671	131	9	that	that	DET
fnp-2671	131	10	same	same	ADJ
fnp-2671	131	11	issue	issue	NOUN
fnp-2671	131	12	of	of	ADP
fnp-2671	131	13	nature	nature	NOUN
fnp-2671	131	14	,	,	PUNCT
fnp-2671	131	15	zeng	zeng	PROPN
fnp-2671	131	16	et	et	PROPN
fnp-2671	131	17	al	al	PROPN
fnp-2671	131	18	demonstrate	demonstrate	VERB
fnp-2671	131	19	the	the	DET
fnp-2671	131	20	existence	existence	NOUN
fnp-2671	131	21	of	of	ADP
fnp-2671	131	22	‘	'	PUNCT
fnp-2671	131	23	pseudo	pseudo	NOUN
fnp-2671	131	24	-	-	ADJ
fnp-2671	131	25	tripartite	tripartite	ADJ
fnp-2671	131	26	synapses	synapsis	NOUN
fnp-2671	131	27	’	'	PUNCT
fnp-2671	131	28	between	between	ADP
fnp-2671	131	29	breast	breast	NOUN
fnp-2671	131	30	cancer	cancer	NOUN
fnp-2671	131	31	cells	cell	NOUN
fnp-2671	131	32	and	and	CCONJ
fnp-2671	131	33	glutamatergic	glutamatergic	ADJ
fnp-2671	131	34	neurons	neuron	NOUN
fnp-2671	131	35	and	and	CCONJ
fnp-2671	131	36	show	show	VERB
fnp-2671	131	37	that	that	SCONJ
fnp-2671	131	38	such	such	ADJ
fnp-2671	131	39	cancer	cancer	NOUN
fnp-2671	131	40	cells	cell	NOUN
fnp-2671	131	41	in	in	ADP
fnp-2671	131	42	the	the	DET
fnp-2671	131	43	brain	brain	NOUN
fnp-2671	131	44	can	can	AUX
fnp-2671	131	45	co	co	VERB
fnp-2671	131	46	-	-	VERB
fnp-2671	131	47	opt	opt	VERB
fnp-2671	131	48	a	a	DET
fnp-2671	131	49	neuronal	neuronal	ADJ
fnp-2671	131	50	signaling	signal	VERB
fnp-2671	131	51	pathway	pathway	NOUN
fnp-2671	131	52	involving	involve	VERB
fnp-2671	131	53	activation	activation	NOUN
fnp-2671	131	54	by	by	ADP
fnp-2671	131	55	glutamate	glutamate	ADJ
fnp-2671	131	56	ligands	ligand	NOUN
fnp-2671	131	57	of	of	ADP
fnp-2671	131	58	n	n	CCONJ
fnp-2671	131	59	-	-	PUNCT
fnp-2671	131	60	methyl	methyl	NOUN
fnp-2671	131	61	-	-	PUNCT
fnp-2671	131	62	d	d	NOUN
fnp-2671	131	63	-	-	PUNCT
fnp-2671	131	64	aspartate	aspartate	ADJ
fnp-2671	131	65	receptors	receptor	NOUN
fnp-2671	131	66	(	(	PUNCT
fnp-2671	131	67	nmdars	nmdar	NOUN
fnp-2671	131	68	)	)	PUNCT
fnp-2671	132	1	[	[	X
fnp-2671	132	2	12	12	NUM
fnp-2671	132	3	]	]	PUNCT
fnp-2671	132	4	.	.	PUNCT
fnp-2671	133	1	these	these	DET
fnp-2671	133	2	three	three	NUM
fnp-2671	133	3	studies	study	NOUN
fnp-2671	133	4	thus	thus	ADV
fnp-2671	133	5	suggest	suggest	VERB
fnp-2671	133	6	very	very	ADV
fnp-2671	133	7	peculiar	peculiar	ADJ
fnp-2671	133	8	brain	brain	NOUN
fnp-2671	133	9	tumor	tumor	NOUN
fnp-2671	133	10	-	-	PUNCT
fnp-2671	133	11	microenvironment	microenvironment	NOUN
fnp-2671	133	12	interactions	interaction	NOUN
fnp-2671	133	13	in	in	ADP
fnp-2671	133	14	the	the	DET
fnp-2671	133	15	form	form	NOUN
fnp-2671	133	16	of	of	ADP
fnp-2671	133	17	direct	direct	ADJ
fnp-2671	133	18	,	,	PUNCT
fnp-2671	133	19	biologically	biologically	ADV
fnp-2671	133	20	relevant	relevant	ADJ
fnp-2671	133	21	synaptic	synaptic	ADJ
fnp-2671	133	22	communication	communication	NOUN
fnp-2671	133	23	between	between	ADP
fnp-2671	133	24	neurons	neuron	NOUN
fnp-2671	133	25	and	and	CCONJ
fnp-2671	133	26	tumor	tumor	NOUN
fnp-2671	133	27	cells	cell	NOUN
fnp-2671	133	28	with	with	ADP
fnp-2671	133	29	potential	potential	ADJ
fnp-2671	133	30	therapeutic	therapeutic	ADJ
fnp-2671	133	31	implications	implication	NOUN
fnp-2671	133	32	.	.	PUNCT
fnp-2671	134	1	fig	fig	NOUN
fnp-2671	134	2	.	.	PUNCT
fnp-2671	135	1	2	2	X
fnp-2671	135	2	.	.	X
fnp-2671	135	3	human	human	ADJ
fnp-2671	135	4	glioma	glioma	NOUN
fnp-2671	135	5	cells	cell	NOUN
fnp-2671	135	6	forming	form	VERB
fnp-2671	135	7	a	a	DET
fnp-2671	135	8	mycelium	mycelium	NOUN
fnp-2671	135	9	-	-	PUNCT
fnp-2671	135	10	like	like	ADJ
fnp-2671	135	11	network	network	NOUN
fnp-2671	135	12	in	in	ADP
fnp-2671	135	13	mouse	mouse	NOUN
fnp-2671	135	14	brain	brain	NOUN
fnp-2671	135	15	.	.	PUNCT
fnp-2671	136	1	based	base	VERB
fnp-2671	136	2	on	on	ADP
fnp-2671	136	3	findings	finding	NOUN
fnp-2671	136	4	in	in	ADP
fnp-2671	136	5	especially	especially	ADV
fnp-2671	136	6	two	two	NUM
fnp-2671	136	7	-	-	PUNCT
fnp-2671	136	8	dimensional	dimensional	ADJ
fnp-2671	136	9	histological	histological	ADJ
fnp-2671	136	10	slides	slide	NOUN
fnp-2671	136	11	,	,	PUNCT
fnp-2671	136	12	tumor	tumor	NOUN
fnp-2671	136	13	cells	cell	NOUN
fnp-2671	136	14	in	in	ADP
fnp-2671	136	15	the	the	DET
fnp-2671	136	16	periphery	periphery	NOUN
fnp-2671	136	17	of	of	ADP
fnp-2671	136	18	diffuse	diffuse	PROPN
fnp-2671	136	19	gliomas	glioma	NOUN
fnp-2671	136	20	have	have	AUX
fnp-2671	136	21	been	be	AUX
fnp-2671	136	22	considered	consider	VERB
fnp-2671	136	23	as	as	ADP
fnp-2671	136	24	‘	'	PUNCT
fnp-2671	136	25	guerilla	guerilla	NOUN
fnp-2671	136	26	warriors	warrior	NOUN
fnp-2671	136	27	’	'	PUNCT
fnp-2671	136	28	that	that	PRON
fnp-2671	136	29	move	move	VERB
fnp-2671	136	30	as	as	ADP
fnp-2671	136	31	single	single	ADJ
fnp-2671	136	32	cells	cell	NOUN
fnp-2671	136	33	into	into	ADP
fnp-2671	136	34	the	the	DET
fnp-2671	136	35	preexistent	preexistent	NOUN
fnp-2671	136	36	cns	cns	NOUN
fnp-2671	136	37	tissue	tissue	NOUN
fnp-2671	136	38	[	[	X
fnp-2671	136	39	41	41	NUM
fnp-2671	136	40	]	]	PUNCT
fnp-2671	136	41	.	.	PUNCT
fnp-2671	137	1	more	more	ADJ
fnp-2671	137	2	recent	recent	ADJ
fnp-2671	137	3	findings	finding	NOUN
fnp-2671	137	4	,	,	PUNCT
fnp-2671	137	5	however	however	ADV
fnp-2671	137	6	,	,	PUNCT
fnp-2671	137	7	show	show	VERB
fnp-2671	137	8	that	that	SCONJ
fnp-2671	137	9	such	such	ADJ
fnp-2671	137	10	cells	cell	NOUN
fnp-2671	137	11	in	in	ADP
fnp-2671	137	12	diffuse	diffuse	ADJ
fnp-2671	137	13	astrocytic	astrocytic	ADJ
fnp-2671	137	14	tumors	tumor	NOUN
fnp-2671	137	15	form	form	VERB
fnp-2671	137	16	a	a	DET
fnp-2671	137	17	network	network	NOUN
fnp-2671	137	18	of	of	ADP
fnp-2671	137	19	microtubes	microtube	NOUN
fnp-2671	137	20	.	.	PUNCT
fnp-2671	138	1	this	this	DET
fnp-2671	138	2	figure	figure	NOUN
fnp-2671	138	3	shows	show	VERB
fnp-2671	138	4	such	such	ADJ
fnp-2671	138	5	network	network	NOUN
fnp-2671	138	6	formation	formation	NOUN
fnp-2671	138	7	by	by	ADP
fnp-2671	138	8	human	human	ADJ
fnp-2671	138	9	glioblastoma	glioblastoma	NOUN
fnp-2671	138	10	cells	cell	NOUN
fnp-2671	138	11	28	28	NUM
fnp-2671	138	12	days	day	NOUN
fnp-2671	138	13	after	after	ADP
fnp-2671	138	14	implantation	implantation	NOUN
fnp-2671	138	15	into	into	ADP
fnp-2671	138	16	a	a	DET
fnp-2671	138	17	mouse	mouse	NOUN
fnp-2671	138	18	brain	brain	NOUN
fnp-2671	138	19	(	(	PUNCT
fnp-2671	138	20	yellow	yellow	ADJ
fnp-2671	138	21	:	:	PUNCT
fnp-2671	138	22	glioblastoma	glioblastoma	NOUN
fnp-2671	138	23	cells	cell	NOUN
fnp-2671	138	24	labeled	label	VERB
fnp-2671	138	25	by	by	ADP
fnp-2671	138	26	human	human	ADJ
fnp-2671	138	27	-	-	PUNCT
fnp-2671	138	28	specific	specific	ADJ
fnp-2671	138	29	anti	anti	ADJ
fnp-2671	138	30	-	-	ADJ
fnp-2671	138	31	vimentin	vimentin	ADJ
fnp-2671	138	32	antibody	antibody	NOUN
fnp-2671	138	33	;	;	PUNCT
fnp-2671	138	34	magenta	magenta	NOUN
fnp-2671	138	35	:	:	PUNCT
fnp-2671	138	36	mouse	mouse	NOUN
fnp-2671	138	37	astrocytes	astrocyte	NOUN
fnp-2671	138	38	labeled	label	VERB
fnp-2671	138	39	by	by	ADP
fnp-2671	138	40	anti	anti	ADJ
fnp-2671	138	41	-	-	ADJ
fnp-2671	138	42	gfap	gfap	ADJ
fnp-2671	138	43	antibody	antibody	NOUN
fnp-2671	138	44	;	;	PUNCT
fnp-2671	138	45	blue	blue	ADJ
fnp-2671	138	46	:	:	PUNCT
fnp-2671	138	47	cell	cell	NOUN
fnp-2671	138	48	nuclei	nucleus	NOUN
fnp-2671	138	49	labeled	label	VERB
fnp-2671	138	50	by	by	ADP
fnp-2671	138	51	dapi	dapi	PROPN
fnp-2671	138	52	;	;	PUNCT
fnp-2671	138	53	figure	figure	NOUN
fnp-2671	138	54	kindly	kindly	ADV
fnp-2671	138	55	provided	provide	VERB
fnp-2671	138	56	by	by	ADP
fnp-2671	138	57	pavel	pavel	PROPN
fnp-2671	138	58	gritsenko	gritsenko	PROPN
fnp-2671	138	59	and	and	CCONJ
fnp-2671	138	60	peter	peter	PROPN
fnp-2671	138	61	friedl	friedl	PROPN
fnp-2671	138	62	and	and	CCONJ
fnp-2671	138	63	based	base	VERB
fnp-2671	138	64	on	on	ADP
fnp-2671	138	65	work	work	NOUN
fnp-2671	138	66	recently	recently	ADV
fnp-2671	138	67	published	publish	VERB
fnp-2671	138	68	[	[	PUNCT
fnp-2671	138	69	61	61	NUM
fnp-2671	138	70	]	]	NUM
fnp-2671	138	71	)	)	PUNCT
fnp-2671	138	72	.	.	PUNCT
fnp-2671	139	1	in	in	ADP
fnp-2671	139	2	addition	addition	NOUN
fnp-2671	139	3	to	to	ADP
fnp-2671	139	4	such	such	DET
fnp-2671	139	5	a	a	DET
fnp-2671	139	6	mycelium	mycelium	NOUN
fnp-2671	139	7	-	-	PUNCT
fnp-2671	139	8	like	like	ADJ
fnp-2671	139	9	network	network	NOUN
fnp-2671	139	10	formation	formation	NOUN
fnp-2671	139	11	,	,	PUNCT
fnp-2671	139	12	studies	study	NOUN
fnp-2671	139	13	discussed	discuss	VERB
fnp-2671	139	14	under	under	ADP
fnp-2671	139	15	topic	topic	NOUN
fnp-2671	139	16	7	7	NUM
fnp-2671	139	17	now	now	ADV
fnp-2671	139	18	report	report	VERB
fnp-2671	139	19	that	that	SCONJ
fnp-2671	139	20	direct	direct	ADJ
fnp-2671	139	21	,	,	PUNCT
fnp-2671	139	22	biologically	biologically	ADV
fnp-2671	139	23	relevant	relevant	ADJ
fnp-2671	139	24	synaptic	synaptic	ADJ
fnp-2671	139	25	communication	communication	NOUN
fnp-2671	139	26	exists	exist	VERB
fnp-2671	139	27	between	between	ADP
fnp-2671	139	28	neurons	neuron	NOUN
fnp-2671	139	29	and	and	CCONJ
fnp-2671	139	30	tumor	tumor	NOUN
fnp-2671	139	31	cells	cell	NOUN
fnp-2671	139	32	as	as	ADV
fnp-2671	139	33	well	well	ADV
fnp-2671	139	34	.	.	PUNCT
fnp-2671	140	1	topic	topic	NOUN
fnp-2671	140	2	8	8	NUM
fnp-2671	140	3	.	.	PUNCT
fnp-2671	141	1	cancer	cancer	NOUN
fnp-2671	141	2	stem	stem	NOUN
fnp-2671	141	3	cells	cell	NOUN
fnp-2671	141	4	in	in	ADP
fnp-2671	141	5	glioblastomas	glioblastoma	NOUN
fnp-2671	141	6	;	;	PUNCT
fnp-2671	141	7	do	do	AUX
fnp-2671	141	8	they	they	PRON
fnp-2671	141	9	exist	exist	VERB
fnp-2671	141	10	?	?	PUNCT
fnp-2671	142	1	[	[	X
fnp-2671	142	2	13	13	NUM
fnp-2671	142	3	]	]	X
fnp-2671	142	4	it	it	PRON
fnp-2671	142	5	is	be	AUX
fnp-2671	142	6	been	be	AUX
fnp-2671	142	7	proposed	propose	VERB
fnp-2671	142	8	that	that	SCONJ
fnp-2671	142	9	in	in	ADP
fnp-2671	142	10	glioblastomas	glioblastomas	PROPN
fnp-2671	142	11	cancer	cancer	NOUN
fnp-2671	142	12	stem	stem	NOUN
fnp-2671	142	13	cells	cell	NOUN
fnp-2671	142	14	(	(	PUNCT
fnp-2671	142	15	cscs	cscs	PROPN
fnp-2671	142	16	)	)	PUNCT
fnp-2671	142	17	or	or	CCONJ
fnp-2671	142	18	stem	stem	NOUN
fnp-2671	142	19	-	-	PUNCT
fnp-2671	142	20	like	like	ADJ
fnp-2671	142	21	cells	cell	NOUN
fnp-2671	142	22	reside	reside	VERB
fnp-2671	142	23	at	at	ADP
fnp-2671	142	24	the	the	DET
fnp-2671	142	25	top	top	NOUN
fnp-2671	142	26	of	of	ADP
fnp-2671	142	27	a	a	DET
fnp-2671	142	28	hierarchical	hierarchical	ADJ
fnp-2671	142	29	organization	organization	NOUN
fnp-2671	142	30	,	,	PUNCT
fnp-2671	142	31	are	be	AUX
fnp-2671	142	32	able	able	ADJ
fnp-2671	142	33	to	to	PART
fnp-2671	142	34	(	(	PUNCT
fnp-2671	142	35	re)create	re)create	VERB
fnp-2671	142	36	intra	intra	ADJ
fnp-2671	142	37	-	-	ADJ
fnp-2671	142	38	tumoral	tumoral	ADJ
fnp-2671	142	39	heterogeneity	heterogeneity	NOUN
fnp-2671	142	40	by	by	ADP
fnp-2671	142	41	generating	generate	VERB
fnp-2671	142	42	more	more	ADV
fnp-2671	142	43	differentiated	differentiated	ADJ
fnp-2671	142	44	offspring	offspring	NOUN
fnp-2671	142	45	,	,	PUNCT
fnp-2671	142	46	and	and	CCONJ
fnp-2671	142	47	are	be	AUX
fnp-2671	142	48	relatively	relatively	ADV
fnp-2671	142	49	resistant	resistant	ADJ
fnp-2671	142	50	to	to	ADP
fnp-2671	142	51	therapy	therapy	NOUN
fnp-2671	142	52	and	and	CCONJ
fnp-2671	142	53	thus	thus	ADV
fnp-2671	142	54	contribute	contribute	VERB
fnp-2671	142	55	significantly	significantly	ADV
fnp-2671	142	56	to	to	ADP
fnp-2671	142	57	tumor	tumor	NOUN
fnp-2671	142	58	recurrence	recurrence	NOUN
fnp-2671	142	59	[	[	X
fnp-2671	142	60	45	45	NUM
fnp-2671	142	61	]	]	PUNCT
fnp-2671	142	62	.	.	PUNCT
fnp-2671	143	1	expression	expression	NOUN
fnp-2671	143	2	of	of	ADP
fnp-2671	143	3	particular	particular	ADJ
fnp-2671	143	4	cell	cell	NOUN
fnp-2671	143	5	membrane	membrane	NOUN
fnp-2671	143	6	antigens	antigen	NOUN
fnp-2671	143	7	(	(	PUNCT
fnp-2671	143	8	cd133	cd133	X
fnp-2671	143	9	,	,	PUNCT
fnp-2671	143	10	cd15	cd15	PROPN
fnp-2671	143	11	/	/	SYM
fnp-2671	143	12	ssea	ssea	NOUN
fnp-2671	143	13	,	,	PUNCT
fnp-2671	143	14	cd44	cd44	PROPN
fnp-2671	143	15	,	,	PUNCT
fnp-2671	143	16	and/or	and/or	CCONJ
fnp-2671	143	17	a2b5	a2b5	VERB
fnp-2671	143	18	)	)	PUNCT
fnp-2671	143	19	has	have	AUX
fnp-2671	143	20	often	often	ADV
fnp-2671	143	21	been	be	AUX
fnp-2671	143	22	used	use	VERB
fnp-2671	143	23	for	for	ADP
fnp-2671	143	24	identification	identification	NOUN
fnp-2671	143	25	of	of	ADP
fnp-2671	143	26	the	the	DET
fnp-2671	143	27	csc	csc	PROPN
fnp-2671	143	28	subset	subset	NOUN
fnp-2671	143	29	in	in	ADP
fnp-2671	143	30	glioblastomas	glioblastoma	NOUN
fnp-2671	143	31	.	.	PUNCT
fnp-2671	144	1	however	however	ADV
fnp-2671	144	2	,	,	PUNCT
fnp-2671	144	3	it	it	PRON
fnp-2671	144	4	is	be	AUX
fnp-2671	144	5	increasingly	increasingly	ADV
fnp-2671	144	6	clear	clear	ADJ
fnp-2671	144	7	that	that	SCONJ
fnp-2671	144	8	no	no	DET
fnp-2671	144	9	single	single	ADJ
fnp-2671	144	10	marker	marker	NOUN
fnp-2671	144	11	allows	allow	VERB
fnp-2671	144	12	for	for	ADP
fnp-2671	144	13	unequivocal	unequivocal	ADJ
fnp-2671	144	14	identification	identification	NOUN
fnp-2671	144	15	of	of	ADP
fnp-2671	144	16	a	a	DET
fnp-2671	144	17	csc	csc	PROPN
fnp-2671	144	18	population	population	NOUN
fnp-2671	144	19	in	in	ADP
fnp-2671	144	20	glioblastomas	glioblastoma	NOUN
fnp-2671	144	21	.	.	PUNCT
fnp-2671	145	1	moreover	moreover	ADV
fnp-2671	145	2	,	,	PUNCT
fnp-2671	145	3	there	there	PRON
fnp-2671	145	4	is	be	VERB
fnp-2671	145	5	still	still	ADV
fnp-2671	145	6	controversy	controversy	NOUN
fnp-2671	145	7	if	if	SCONJ
fnp-2671	145	8	a	a	DET
fnp-2671	145	9	bona	bona	ADJ
fnp-2671	145	10	fide	fide	X
fnp-2671	145	11	csc	csc	PROPN
fnp-2671	145	12	population	population	NOUN
fnp-2671	145	13	exists	exist	VERB
fnp-2671	145	14	at	at	ADV
fnp-2671	145	15	all	all	ADV
fnp-2671	145	16	(	(	PUNCT
fnp-2671	145	17	and	and	CCONJ
fnp-2671	145	18	if	if	SCONJ
fnp-2671	145	19	so	so	ADV
fnp-2671	145	20	,	,	PUNCT
fnp-2671	145	21	if	if	SCONJ
fnp-2671	145	22	it	it	PRON
fnp-2671	145	23	concerns	concern	VERB
fnp-2671	145	24	a	a	DET
fnp-2671	145	25	quiescent	quiescent	ADJ
fnp-2671	145	26	or	or	CCONJ
fnp-2671	145	27	proliferative	proliferative	ADJ
fnp-2671	145	28	subpopulation	subpopulation	NOUN
fnp-2671	145	29	)	)	PUNCT
fnp-2671	145	30	.	.	PUNCT
fnp-2671	146	1	in	in	ADP
fnp-2671	146	2	this	this	DET
fnp-2671	146	3	context	context	NOUN
fnp-2671	146	4	,	,	PUNCT
fnp-2671	146	5	dirkse	dirkse	NOUN
fnp-2671	146	6	et	et	NOUN
fnp-2671	146	7	al	al	PROPN
fnp-2671	146	8	addressed	address	VERB
fnp-2671	146	9	the	the	DET
fnp-2671	146	10	question	question	NOUN
fnp-2671	146	11	whether	whether	SCONJ
fnp-2671	146	12	glioblastoma	glioblastoma	NOUN
fnp-2671	146	13	cells	cell	NOUN
fnp-2671	146	14	expressing	express	VERB
fnp-2671	146	15	csc	csc	ADJ
fnp-2671	146	16	-	-	PUNCT
fnp-2671	146	17	associated	associate	VERB
fnp-2671	146	18	cell	cell	NOUN
fnp-2671	146	19	membrane	membrane	NOUN
fnp-2671	146	20	markers	marker	NOUN
fnp-2671	146	21	are	be	AUX
fnp-2671	146	22	indeed	indeed	ADV
fnp-2671	146	23	a	a	DET
fnp-2671	146	24	defined	define	VERB
fnp-2671	146	25	entity	entity	NOUN
fnp-2671	146	26	at	at	ADP
fnp-2671	146	27	the	the	DET
fnp-2671	146	28	apex	apex	NOUN
fnp-2671	146	29	of	of	ADP
fnp-2671	146	30	a	a	DET
fnp-2671	146	31	hierarchical	hierarchical	ADJ
fnp-2671	146	32	organization	organization	NOUN
fnp-2671	146	33	.	.	PUNCT
fnp-2671	147	1	they	they	PRON
fnp-2671	147	2	found	find	VERB
fnp-2671	147	3	that	that	SCONJ
fnp-2671	147	4	,	,	PUNCT
fnp-2671	147	5	like	like	ADP
fnp-2671	147	6	in	in	ADP
fnp-2671	147	7	patient	patient	ADJ
fnp-2671	147	8	biopsies	biopsy	NOUN
fnp-2671	147	9	,	,	PUNCT
fnp-2671	147	10	csc	csc	PROPN
fnp-2671	147	11	markers	marker	NOUN
fnp-2671	147	12	were	be	AUX
fnp-2671	147	13	heterogeneously	heterogeneously	ADV
fnp-2671	147	14	expressed	express	VERB
fnp-2671	147	15	in	in	ADP
fnp-2671	147	16	patient	patient	NOUN
fnp-2671	147	17	-	-	PUNCT
fnp-2671	147	18	derived	derive	VERB
fnp-2671	147	19	glioblastoma	glioblastoma	NOUN
fnp-2671	147	20	xenografts	xenograft	NOUN
fnp-2671	147	21	and	and	CCONJ
fnp-2671	147	22	stem	stem	NOUN
fnp-2671	147	23	-	-	PUNCT
fnp-2671	147	24	like	like	ADJ
fnp-2671	147	25	cell	cell	NOUN
fnp-2671	147	26	cultures	culture	NOUN
fnp-2671	147	27	.	.	PUNCT
fnp-2671	148	1	more	more	ADV
fnp-2671	148	2	precisely	precisely	ADV
fnp-2671	148	3	,	,	PUNCT
fnp-2671	148	4	all	all	DET
fnp-2671	148	5	facs	fac	NOUN
fnp-2671	148	6	-	-	PUNCT
fnp-2671	148	7	sorted	sort	VERB
fnp-2671	148	8	subpopulations	subpopulation	NOUN
fnp-2671	148	9	of	of	ADP
fnp-2671	148	10	tumor	tumor	NOUN
fnp-2671	148	11	cells	cell	NOUN
fnp-2671	148	12	of	of	ADP
fnp-2671	148	13	glioblastomas	glioblastoma	NOUN
fnp-2671	148	14	were	be	AUX
fnp-2671	148	15	able	able	ADJ
fnp-2671	148	16	to	to	PART
fnp-2671	148	17	self	self	NOUN
fnp-2671	148	18	-	-	PUNCT
fnp-2671	148	19	renew	renew	NOUN
fnp-2671	148	20	over	over	ADP
fnp-2671	148	21	multiple	multiple	ADJ
fnp-2671	148	22	passages	passage	NOUN
fnp-2671	148	23	without	without	ADP
fnp-2671	148	24	significant	significant	ADJ
fnp-2671	148	25	differences	difference	NOUN
fnp-2671	148	26	between	between	ADP
fnp-2671	148	27	each	each	DET
fnp-2671	148	28	other	other	ADJ
fnp-2671	148	29	.	.	PUNCT
fnp-2671	149	1	this	this	PRON
fnp-2671	149	2	suggests	suggest	VERB
fnp-2671	149	3	that	that	SCONJ
fnp-2671	149	4	phenotypically	phenotypically	ADV
fnp-2671	149	5	heterogeneous	heterogeneous	ADJ
fnp-2671	149	6	glioblastoma	glioblastoma	NOUN
fnp-2671	149	7	cells	cell	NOUN
fnp-2671	149	8	can	can	AUX
fnp-2671	149	9	adapt	adapt	VERB
fnp-2671	149	10	to	to	ADP
fnp-2671	149	11	a	a	DET
fnp-2671	149	12	variety	variety	NOUN
fnp-2671	149	13	of	of	ADP
fnp-2671	149	14	environmental	environmental	ADJ
fnp-2671	149	15	changes	change	NOUN
fnp-2671	149	16	and	and	CCONJ
fnp-2671	149	17	acquire	acquire	VERB
fnp-2671	149	18	similar	similar	ADJ
fnp-2671	149	19	stem	stem	NOUN
fnp-2671	149	20	cell	cell	NOUN
fnp-2671	149	21	properties	property	NOUN
fnp-2671	149	22	in	in	ADP
fnp-2671	149	23	vitro	vitro	VERB
fnp-2671	149	24	.	.	PUNCT
fnp-2671	150	1	dirkse	dirkse	NOUN
fnp-2671	150	2	et	et	PROPN
fnp-2671	150	3	al	al	PROPN
fnp-2671	150	4	also	also	ADV
fnp-2671	150	5	found	find	VERB
fnp-2671	150	6	that	that	SCONJ
fnp-2671	150	7	accelerated	accelerate	VERB
fnp-2671	150	8	reconstitution	reconstitution	NOUN
fnp-2671	150	9	of	of	ADP
fnp-2671	150	10	heterogeneity	heterogeneity	NOUN
fnp-2671	150	11	provided	provide	VERB
fnp-2671	150	12	a	a	DET
fnp-2671	150	13	growth	growth	NOUN
fnp-2671	150	14	advantage	advantage	NOUN
fnp-2671	150	15	in	in	ADP
fnp-2671	150	16	vivo	vivo	NOUN
fnp-2671	150	17	,	,	PUNCT
fnp-2671	150	18	suggesting	suggest	VERB
fnp-2671	150	19	that	that	SCONJ
fnp-2671	150	20	tumorigenic	tumorigenic	ADJ
fnp-2671	150	21	potential	potential	NOUN
fnp-2671	150	22	is	be	AUX
fnp-2671	150	23	linked	link	VERB
fnp-2671	150	24	to	to	ADP
fnp-2671	150	25	intrinsic	intrinsic	ADJ
fnp-2671	150	26	plasticity	plasticity	NOUN
fnp-2671	150	27	rather	rather	ADV
fnp-2671	150	28	than	than	ADP
fnp-2671	150	29	csc	csc	PROPN
fnp-2671	150	30	multipotency	multipotency	NOUN
fnp-2671	150	31	.	.	PUNCT
fnp-2671	151	1	the	the	DET
fnp-2671	151	2	study	study	NOUN
fnp-2671	151	3	of	of	ADP
fnp-2671	151	4	dirkse	dirkse	NOUN
fnp-2671	151	5	et	et	PROPN
fnp-2671	151	6	al	al	PROPN
fnp-2671	151	7	thus	thus	ADV
fnp-2671	151	8	provides	provide	VERB
fnp-2671	151	9	strong	strong	ADJ
fnp-2671	151	10	evidence	evidence	NOUN
fnp-2671	151	11	that	that	SCONJ
fnp-2671	151	12	cscs	cscs	PROPN
fnp-2671	151	13	do	do	AUX
fnp-2671	151	14	not	not	PART
fnp-2671	151	15	constitute	constitute	VERB
fnp-2671	151	16	a	a	DET
fnp-2671	151	17	defined	define	VERB
fnp-2671	151	18	cellular	cellular	ADJ
fnp-2671	151	19	entity	entity	NOUN
fnp-2671	151	20	,	,	PUNCT
fnp-2671	151	21	but	but	CCONJ
fnp-2671	151	22	rather	rather	ADV
fnp-2671	151	23	a	a	DET
fnp-2671	151	24	cellular	cellular	ADJ
fnp-2671	151	25	state	state	NOUN
fnp-2671	151	26	adapting	adapt	VERB
fnp-2671	151	27	to	to	ADP
fnp-2671	151	28	microenvironmental	microenvironmental	ADJ
fnp-2671	151	29	cues	cue	NOUN
fnp-2671	151	30	.	.	PUNCT
fnp-2671	152	1	the	the	DET
fnp-2671	152	2	capacity	capacity	NOUN
fnp-2671	152	3	of	of	ADP
fnp-2671	152	4	any	any	DET
fnp-2671	152	5	given	give	VERB
fnp-2671	152	6	tumor	tumor	NOUN
fnp-2671	152	7	cell	cell	NOUN
fnp-2671	152	8	to	to	PART
fnp-2671	152	9	reconstitute	reconstitute	VERB
fnp-2671	152	10	heterogeneity	heterogeneity	NOUN
fnp-2671	152	11	in	in	ADP
fnp-2671	152	12	glioblastomas	glioblastomas	PROPN
fnp-2671	152	13	cautions	caution	VERB
fnp-2671	152	14	against	against	ADP
fnp-2671	152	15	therapies	therapy	NOUN
fnp-2671	152	16	targeting	target	VERB
fnp-2671	152	17	only	only	ADV
fnp-2671	152	18	a	a	DET
fnp-2671	152	19	small	small	ADJ
fnp-2671	152	20	subpopulation	subpopulation	NOUN
fnp-2671	152	21	of	of	ADP
fnp-2671	152	22	tumor	tumor	NOUN
fnp-2671	152	23	cells	cell	NOUN
fnp-2671	152	24	with	with	ADP
fnp-2671	152	25	stem	stem	NOUN
fnp-2671	152	26	cell(-like	cell(-like	NOUN
fnp-2671	152	27	)	)	PUNCT
fnp-2671	152	28	characteristics	characteristic	NOUN
fnp-2671	152	29	.	.	PUNCT
fnp-2671	153	1	meanwhile	meanwhile	ADV
fnp-2671	153	2	,	,	PUNCT
fnp-2671	153	3	inherent	inherent	ADJ
fnp-2671	153	4	cancer	cancer	NOUN
fnp-2671	153	5	cell	cell	NOUN
fnp-2671	153	6	plasticity	plasticity	NOUN
fnp-2671	153	7	emerges	emerge	VERB
fnp-2671	153	8	as	as	ADP
fnp-2671	153	9	a	a	DET
fnp-2671	153	10	novel	novel	ADJ
fnp-2671	153	11	relevant	relevant	ADJ
fnp-2671	153	12	target	target	NOUN
fnp-2671	153	13	for	for	ADP
fnp-2671	153	14	treatment	treatment	NOUN
fnp-2671	153	15	[	[	X
fnp-2671	153	16	13	13	NUM
fnp-2671	153	17	]	]	PUNCT
fnp-2671	153	18	.	.	PUNCT
fnp-2671	154	1	topic	topic	NOUN
fnp-2671	154	2	9	9	NUM
fnp-2671	154	3	.	.	PUNCT
fnp-2671	155	1	personalized	personalize	VERB
fnp-2671	155	2	(	(	PUNCT
fnp-2671	155	3	neo)antigen	neo)antigen	NOUN
fnp-2671	155	4	vaccination	vaccination	NOUN
fnp-2671	155	5	therapy	therapy	NOUN
fnp-2671	155	6	for	for	ADP
fnp-2671	155	7	glioblastoma	glioblastoma	NOUN
fnp-2671	155	8	[	[	X
fnp-2671	155	9	14	14	NUM
fnp-2671	155	10	,	,	PUNCT
fnp-2671	155	11	15	15	NUM
fnp-2671	155	12	]	]	PUNCT
fnp-2671	155	13	in	in	ADP
fnp-2671	155	14	patients	patient	NOUN
fnp-2671	155	15	with	with	ADP
fnp-2671	155	16	e.g.	e.g.	ADJ
fnp-2671	155	17	melanomas	melanomas	NOUN
fnp-2671	155	18	,	,	PUNCT
fnp-2671	155	19	high	high	ADJ
fnp-2671	155	20	tumor	tumor	NOUN
fnp-2671	155	21	mutational	mutational	ADJ
fnp-2671	155	22	load	load	NOUN
fnp-2671	155	23	(	(	PUNCT
fnp-2671	155	24	tml	tml	NOUN
fnp-2671	155	25	)	)	PUNCT
fnp-2671	155	26	is	be	AUX
fnp-2671	155	27	associated	associate	VERB
fnp-2671	155	28	with	with	ADP
fnp-2671	155	29	increased	increase	VERB
fnp-2671	155	30	frequency	frequency	NOUN
fnp-2671	155	31	of	of	ADP
fnp-2671	155	32	neoantigens	neoantigen	NOUN
fnp-2671	155	33	and	and	CCONJ
fnp-2671	155	34	improved	improved	ADJ
fnp-2671	155	35	response	response	NOUN
fnp-2671	155	36	to	to	ADP
fnp-2671	155	37	checkpoint	checkpoint	NOUN
fnp-2671	155	38	inhibition	inhibition	NOUN
fnp-2671	155	39	.	.	PUNCT
fnp-2671	156	1	administration	administration	NOUN
fnp-2671	156	2	of	of	ADP
fnp-2671	156	3	personalized	personalize	VERB
fnp-2671	156	4	neoantigen	neoantigen	NOUN
fnp-2671	156	5	vaccines	vaccine	NOUN
fnp-2671	156	6	has	have	AUX
fnp-2671	156	7	been	be	AUX
fnp-2671	156	8	shown	show	VERB
fnp-2671	156	9	to	to	PART
fnp-2671	156	10	successfully	successfully	ADV
fnp-2671	156	11	recruit	recruit	VERB
fnp-2671	156	12	t	t	NOUN
fnp-2671	156	13	cells	cell	NOUN
fnp-2671	156	14	to	to	ADP
fnp-2671	156	15	the	the	DET
fnp-2671	156	16	tumor	tumor	NOUN
fnp-2671	156	17	and	and	CCONJ
fnp-2671	156	18	can	can	AUX
fnp-2671	156	19	lead	lead	VERB
fnp-2671	156	20	to	to	ADP
fnp-2671	156	21	tumor	tumor	NOUN
fnp-2671	156	22	regression	regression	NOUN
fnp-2671	156	23	.	.	PUNCT
fnp-2671	157	1	unfortunately	unfortunately	ADV
fnp-2671	157	2	,	,	PUNCT
fnp-2671	157	3	also	also	ADV
fnp-2671	157	4	after	after	ADP
fnp-2671	157	5	the	the	DET
fnp-2671	157	6	introduction	introduction	NOUN
fnp-2671	157	7	of	of	ADP
fnp-2671	157	8	immunotherapies	immunotherapy	NOUN
fnp-2671	157	9	,	,	PUNCT
fnp-2671	157	10	so	so	ADV
fnp-2671	157	11	far	far	ADV
fnp-2671	157	12	the	the	DET
fnp-2671	157	13	very	very	ADV
fnp-2671	157	14	poor	poor	ADJ
fnp-2671	157	15	survival	survival	NOUN
fnp-2671	157	16	rates	rate	NOUN
fnp-2671	157	17	for	for	ADP
fnp-2671	157	18	patients	patient	NOUN
fnp-2671	157	19	with	with	ADP
fnp-2671	157	20	glioblastoma	glioblastoma	NOUN
fnp-2671	157	21	have	have	AUX
fnp-2671	157	22	not	not	PART
fnp-2671	157	23	improved	improve	VERB
fnp-2671	157	24	much	much	ADV
fnp-2671	157	25	.	.	PUNCT
fnp-2671	158	1	of	of	ADP
fnp-2671	158	2	note	note	NOUN
fnp-2671	158	3	,	,	PUNCT
fnp-2671	158	4	glioblastomas	glioblastoma	NOUN
fnp-2671	158	5	often	often	ADV
fnp-2671	158	6	have	have	VERB
fnp-2671	158	7	a	a	DET
fnp-2671	158	8	relatively	relatively	ADV
fnp-2671	158	9	low	low	ADJ
fnp-2671	158	10	mutational	mutational	ADJ
fnp-2671	158	11	burden	burden	NOUN
fnp-2671	158	12	and	and	CCONJ
fnp-2671	158	13	are	be	AUX
fnp-2671	158	14	considered	consider	VERB
fnp-2671	158	15	as	as	ADP
fnp-2671	158	16	immunologically	immunologically	ADV
fnp-2671	158	17	‘	'	PUNCT
fnp-2671	158	18	cold	cold	ADJ
fnp-2671	158	19	’	'	PUNCT
fnp-2671	158	20	.	.	PUNCT
fnp-2671	159	1	recent	recent	ADJ
fnp-2671	159	2	studies	study	NOUN
fnp-2671	159	3	suggest	suggest	VERB
fnp-2671	159	4	that	that	SCONJ
fnp-2671	159	5	for	for	SCONJ
fnp-2671	159	6	patients	patient	NOUN
fnp-2671	159	7	with	with	ADP
fnp-2671	159	8	glioblastoma	glioblastoma	NOUN
fnp-2671	159	9	,	,	PUNCT
fnp-2671	159	10	a	a	DET
fnp-2671	159	11	personalized	personalize	VERB
fnp-2671	159	12	molecular	molecular	ADJ
fnp-2671	159	13	approach	approach	NOUN
fnp-2671	159	14	is	be	AUX
fnp-2671	159	15	needed	need	VERB
fnp-2671	159	16	to	to	PART
fnp-2671	159	17	improve	improve	VERB
fnp-2671	159	18	the	the	DET
fnp-2671	159	19	benefit	benefit	NOUN
fnp-2671	159	20	of	of	ADP
fnp-2671	159	21	treatment	treatment	NOUN
fnp-2671	159	22	with	with	ADP
fnp-2671	159	23	programmed	program	VERB
fnp-2671	159	24	cell	cell	NOUN
fnp-2671	159	25	death	death	NOUN
fnp-2671	159	26	protein	protein	NOUN
fnp-2671	159	27	1	1	NUM
fnp-2671	159	28	(	(	PUNCT
fnp-2671	159	29	pd-1	pd-1	NOUN
fnp-2671	159	30	)	)	PUNCT
fnp-2671	159	31	inhibitors	inhibitor	NOUN
fnp-2671	159	32	nivolumab	nivolumab	ADV
fnp-2671	159	33	or	or	CCONJ
fnp-2671	159	34	pembrolizumab	pembrolizumab	NOUN
fnp-2671	159	35	,	,	PUNCT
fnp-2671	159	36	and	and	CCONJ
fnp-2671	159	37	that	that	SCONJ
fnp-2671	159	38	the	the	DET
fnp-2671	159	39	neoadjuvant	neoadjuvant	ADJ
fnp-2671	159	40	administration	administration	NOUN
fnp-2671	159	41	of	of	ADP
fnp-2671	159	42	pd-1	pd-1	NOUN
fnp-2671	159	43	blockade	blockade	NOUN
fnp-2671	159	44	may	may	AUX
fnp-2671	159	45	represent	represent	VERB
fnp-2671	159	46	a	a	DET
fnp-2671	159	47	more	more	ADV
fnp-2671	159	48	efficacious	efficacious	ADJ
fnp-2671	159	49	approach	approach	NOUN
fnp-2671	159	50	for	for	ADP
fnp-2671	159	51	these	these	DET
fnp-2671	159	52	tumors	tumor	NOUN
fnp-2671	160	1	[	[	X
fnp-2671	160	2	46	46	NUM
fnp-2671	160	3	,	,	PUNCT
fnp-2671	160	4	47	47	NUM
fnp-2671	160	5	]	]	PUNCT
fnp-2671	160	6	.	.	PUNCT
fnp-2671	161	1	two	two	NUM
fnp-2671	161	2	recent	recent	ADJ
fnp-2671	161	3	studies	study	NOUN
fnp-2671	161	4	published	publish	VERB
fnp-2671	161	5	in	in	ADP
fnp-2671	161	6	nature	nature	NOUN
fnp-2671	161	7	explored	explore	VERB
fnp-2671	161	8	the	the	DET
fnp-2671	161	9	feasibility	feasibility	NOUN
fnp-2671	161	10	of	of	ADP
fnp-2671	161	11	vaccination	vaccination	NOUN
fnp-2671	161	12	therapy	therapy	NOUN
fnp-2671	161	13	using	use	VERB
fnp-2671	161	14	tumor	tumor	NOUN
fnp-2671	161	15	(	(	PUNCT
fnp-2671	161	16	neo)antigens	neo)antigen	NOUN
fnp-2671	161	17	for	for	ADP
fnp-2671	161	18	patients	patient	NOUN
fnp-2671	161	19	with	with	ADP
fnp-2671	161	20	glioblastoma	glioblastoma	NOUN
fnp-2671	161	21	.	.	PUNCT
fnp-2671	162	1	keskin	keskin	PROPN
fnp-2671	162	2	et	et	PROPN
fnp-2671	162	3	al	al	PROPN
fnp-2671	162	4	performed	perform	VERB
fnp-2671	162	5	a	a	DET
fnp-2671	162	6	phase	phase	NOUN
fnp-2671	162	7	i	i	PRON
fnp-2671	162	8	/	/	SYM
fnp-2671	162	9	ib	ib	NOUN
fnp-2671	162	10	multi	multi	NOUN
fnp-2671	162	11	-	-	NOUN
fnp-2671	162	12	epitope	epitope	PROPN
fnp-2671	162	13	,	,	PUNCT
fnp-2671	162	14	personalized	personalize	VERB
fnp-2671	162	15	neoantigen	neoantigen	NOUN
fnp-2671	162	16	vaccination	vaccination	NOUN
fnp-2671	162	17	study	study	NOUN
fnp-2671	162	18	[	[	X
fnp-2671	162	19	14	14	NUM
fnp-2671	162	20	]	]	PUNCT
fnp-2671	162	21	.	.	PUNCT
fnp-2671	163	1	patients	patient	NOUN
fnp-2671	163	2	who	who	PRON
fnp-2671	163	3	did	do	AUX
fnp-2671	163	4	not	not	PART
fnp-2671	163	5	receive	receive	VERB
fnp-2671	163	6	dexamethasone	dexamethasone	NOUN
fnp-2671	163	7	generated	generate	VERB
fnp-2671	163	8	circulating	circulate	VERB
fnp-2671	163	9	polyfunctional	polyfunctional	ADJ
fnp-2671	163	10	neoantigen	neoantigen	NOUN
fnp-2671	163	11	-	-	PUNCT
fnp-2671	163	12	specific	specific	ADJ
fnp-2671	163	13	cd4	cd4	PROPN
fnp-2671	163	14	+	+	PROPN
fnp-2671	163	15	and	and	CCONJ
fnp-2671	163	16	cd8	cd8	PROPN
fnp-2671	163	17	+	+	PROPN
fnp-2671	163	18	t	t	PROPN
fnp-2671	163	19	cell	cell	NOUN
fnp-2671	163	20	responses	response	NOUN
fnp-2671	163	21	that	that	PRON
fnp-2671	163	22	were	be	AUX
fnp-2671	163	23	enriched	enrich	VERB
fnp-2671	163	24	in	in	ADP
fnp-2671	163	25	a	a	DET
fnp-2671	163	26	memory	memory	NOUN
fnp-2671	163	27	phenotype	phenotype	NOUN
fnp-2671	163	28	.	.	PUNCT
fnp-2671	164	1	after	after	ADP
fnp-2671	164	2	vaccination	vaccination	NOUN
fnp-2671	164	3	,	,	PUNCT
fnp-2671	164	4	neoantigen	neoantigen	NOUN
fnp-2671	164	5	-	-	PUNCT
fnp-2671	164	6	specific	specific	ADJ
fnp-2671	164	7	t	t	NOUN
fnp-2671	164	8	cells	cell	NOUN
fnp-2671	164	9	were	be	AUX
fnp-2671	164	10	found	find	VERB
fnp-2671	164	11	to	to	PART
fnp-2671	164	12	migrate	migrate	VERB
fnp-2671	164	13	from	from	ADP
fnp-2671	164	14	peripheral	peripheral	ADJ
fnp-2671	164	15	blood	blood	NOUN
fnp-2671	164	16	into	into	ADP
fnp-2671	164	17	the	the	DET
fnp-2671	164	18	glioblastoma	glioblastoma	NOUN
fnp-2671	164	19	,	,	PUNCT
fnp-2671	164	20	suggesting	suggest	VERB
fnp-2671	164	21	that	that	SCONJ
fnp-2671	164	22	they	they	PRON
fnp-2671	164	23	may	may	AUX
fnp-2671	164	24	favorably	favorably	ADV
fnp-2671	164	25	alter	alter	VERB
fnp-2671	164	26	the	the	DET
fnp-2671	164	27	immune	immune	ADJ
fnp-2671	164	28	milieu	milieu	NOUN
fnp-2671	164	29	of	of	ADP
fnp-2671	164	30	the	the	DET
fnp-2671	164	31	tumor	tumor	NOUN
fnp-2671	165	1	[	[	X
fnp-2671	165	2	14	14	NUM
fnp-2671	165	3	]	]	PUNCT
fnp-2671	165	4	.	.	PUNCT
fnp-2671	166	1	hilf	hilf	PROPN
fnp-2671	166	2	et	et	PROPN
fnp-2671	166	3	al	al	PROPN
fnp-2671	166	4	studied	study	VERB
fnp-2671	166	5	vaccination	vaccination	NOUN
fnp-2671	166	6	using	use	VERB
fnp-2671	166	7	both	both	CCONJ
fnp-2671	166	8	unmutated	unmutated	ADJ
fnp-2671	166	9	tumor	tumor	NOUN
fnp-2671	166	10	antigens	antigen	NOUN
fnp-2671	166	11	and	and	CCONJ
fnp-2671	166	12	neoepitopes	neoepitope	NOUN
fnp-2671	166	13	for	for	ADP
fnp-2671	166	14	more	more	ADV
fnp-2671	166	15	effective	effective	ADJ
fnp-2671	166	16	immunotherapy	immunotherapy	NOUN
fnp-2671	166	17	of	of	ADP
fnp-2671	166	18	glioblastomas	glioblastoma	NOUN
fnp-2671	166	19	,	,	PUNCT
fnp-2671	166	20	including	include	VERB
fnp-2671	166	21	those	those	PRON
fnp-2671	166	22	with	with	ADP
fnp-2671	166	23	a	a	DET
fnp-2671	166	24	low	low	ADJ
fnp-2671	166	25	mutational	mutational	ADJ
fnp-2671	166	26	load	load	NOUN
fnp-2671	166	27	[	[	X
fnp-2671	166	28	15	15	NUM
fnp-2671	166	29	]	]	PUNCT
fnp-2671	166	30	.	.	PUNCT
fnp-2671	167	1	highly	highly	ADV
fnp-2671	167	2	individualized	individualized	ADJ
fnp-2671	167	3	vaccinations	vaccination	NOUN
fnp-2671	167	4	with	with	ADP
fnp-2671	167	5	both	both	DET
fnp-2671	167	6	types	type	NOUN
fnp-2671	167	7	of	of	ADP
fnp-2671	167	8	tumor	tumor	NOUN
fnp-2671	167	9	antigens	antigen	NOUN
fnp-2671	167	10	were	be	AUX
fnp-2671	167	11	integrated	integrate	VERB
fnp-2671	167	12	into	into	ADP
fnp-2671	167	13	standard	standard	ADJ
fnp-2671	167	14	care	care	NOUN
fnp-2671	167	15	for	for	ADP
fnp-2671	167	16	patients	patient	NOUN
fnp-2671	167	17	with	with	ADP
fnp-2671	167	18	newly	newly	ADV
fnp-2671	167	19	diagnosed	diagnose	VERB
fnp-2671	167	20	glioblastoma	glioblastoma	NOUN
fnp-2671	167	21	.	.	PUNCT
fnp-2671	168	1	fifteen	fifteen	NUM
fnp-2671	168	2	patients	patient	NOUN
fnp-2671	168	3	were	be	AUX
fnp-2671	168	4	first	first	ADV
fnp-2671	168	5	treated	treat	VERB
fnp-2671	168	6	with	with	ADP
fnp-2671	168	7	a	a	DET
fnp-2671	168	8	vaccine	vaccine	NOUN
fnp-2671	168	9	with	with	ADP
fnp-2671	168	10	a	a	DET
fnp-2671	168	11	previously	previously	ADV
fnp-2671	168	12	constructed	construct	VERB
fnp-2671	168	13	library	library	NOUN
fnp-2671	168	14	of	of	ADP
fnp-2671	168	15	non	non	ADJ
fnp-2671	168	16	-	-	ADJ
fnp-2671	168	17	mutated	mutate	VERB
fnp-2671	168	18	antigens	antigen	NOUN
fnp-2671	168	19	that	that	PRON
fnp-2671	168	20	are	be	AUX
fnp-2671	168	21	over	over	ADV
fnp-2671	168	22	-	-	PUNCT
fnp-2671	168	23	represented	represent	VERB
fnp-2671	168	24	in	in	ADP
fnp-2671	168	25	glioblastomas	glioblastoma	NOUN
fnp-2671	168	26	(	(	PUNCT
fnp-2671	168	27	apvac1	apvac1	NOUN
fnp-2671	168	28	)	)	PUNCT
fnp-2671	168	29	,	,	PUNCT
fnp-2671	168	30	followed	follow	VERB
fnp-2671	168	31	by	by	ADP
fnp-2671	168	32	a	a	DET
fnp-2671	168	33	second	second	ADJ
fnp-2671	168	34	vaccine	vaccine	NOUN
fnp-2671	168	35	(	(	PUNCT
fnp-2671	168	36	apvac2	apvac2	PROPN
fnp-2671	168	37	)	)	PUNCT
fnp-2671	168	38	targeted	target	VERB
fnp-2671	168	39	against	against	ADP
fnp-2671	168	40	mutated	mutate	VERB
fnp-2671	168	41	neoantigens	neoantigen	NOUN
fnp-2671	168	42	or	or	CCONJ
fnp-2671	168	43	non	non	ADJ
fnp-2671	168	44	-	-	ADJ
fnp-2671	168	45	mutated	mutate	VERB
fnp-2671	168	46	antigens	antigen	NOUN
fnp-2671	168	47	that	that	PRON
fnp-2671	168	48	were	be	AUX
fnp-2671	168	49	not	not	PART
fnp-2671	168	50	present	present	ADJ
fnp-2671	168	51	in	in	ADP
fnp-2671	168	52	apvac1	apvac1	NOUN
fnp-2671	168	53	.	.	PUNCT
fnp-2671	169	1	the	the	DET
fnp-2671	169	2	vaccines	vaccine	NOUN
fnp-2671	169	3	were	be	AUX
fnp-2671	169	4	personalized	personalize	VERB
fnp-2671	169	5	by	by	ADP
fnp-2671	169	6	analysis	analysis	NOUN
fnp-2671	169	7	of	of	ADP
fnp-2671	169	8	mutations	mutation	NOUN
fnp-2671	169	9	and	and	CCONJ
fnp-2671	169	10	of	of	ADP
fnp-2671	169	11	the	the	DET
fnp-2671	169	12	transcriptomes	transcriptome	NOUN
fnp-2671	169	13	and	and	CCONJ
fnp-2671	169	14	immunopeptidomes	immunopeptidome	NOUN
fnp-2671	169	15	of	of	ADP
fnp-2671	169	16	the	the	DET
fnp-2671	169	17	individual	individual	ADJ
fnp-2671	169	18	tumors	tumor	NOUN
fnp-2671	169	19	.	.	PUNCT
fnp-2671	170	1	both	both	DET
fnp-2671	170	2	vaccines	vaccine	NOUN
fnp-2671	170	3	showed	show	VERB
fnp-2671	170	4	favorable	favorable	ADJ
fnp-2671	170	5	safety	safety	NOUN
fnp-2671	170	6	and	and	CCONJ
fnp-2671	170	7	elicited	elicit	VERB
fnp-2671	170	8	t	t	NOUN
fnp-2671	170	9	cell	cell	NOUN
fnp-2671	170	10	responses	response	NOUN
fnp-2671	170	11	against	against	ADP
fnp-2671	170	12	the	the	DET
fnp-2671	170	13	proteins	protein	NOUN
fnp-2671	170	14	in	in	ADP
fnp-2671	170	15	the	the	DET
fnp-2671	170	16	vaccine	vaccine	NOUN
fnp-2671	170	17	,	,	PUNCT
fnp-2671	170	18	with	with	ADP
fnp-2671	170	19	apvac1	apvac1	NOUN
fnp-2671	170	20	inducing	induce	VERB
fnp-2671	170	21	a	a	DET
fnp-2671	170	22	sustained	sustained	ADJ
fnp-2671	170	23	cd8	cd8	PROPN
fnp-2671	170	24	+	+	PROPN
fnp-2671	170	25	t	t	PROPN
fnp-2671	170	26	cell	cell	NOUN
fnp-2671	170	27	response	response	NOUN
fnp-2671	170	28	,	,	PUNCT
fnp-2671	170	29	and	and	CCONJ
fnp-2671	170	30	apvac2	apvac2	PROPN
fnp-2671	170	31	both	both	CCONJ
fnp-2671	170	32	cd4	cd4	PROPN
fnp-2671	170	33	+	+	PROPN
fnp-2671	170	34	and	and	CCONJ
fnp-2671	170	35	cd8	cd8	PROPN
fnp-2671	170	36	+	+	PROPN
fnp-2671	170	37	t	t	PROPN
fnp-2671	170	38	cell	cell	NOUN
fnp-2671	170	39	responses	response	NOUN
fnp-2671	170	40	[	[	X
fnp-2671	170	41	15	15	NUM
fnp-2671	170	42	]	]	PUNCT
fnp-2671	170	43	.	.	PUNCT
fnp-2671	171	1	topic	topic	NOUN
fnp-2671	171	2	10	10	NUM
fnp-2671	171	3	.	.	PUNCT
fnp-2671	172	1	liquid	liquid	ADJ
fnp-2671	172	2	biopsy	biopsy	NOUN
fnp-2671	172	3	diagnosis	diagnosis	NOUN
fnp-2671	172	4	of	of	ADP
fnp-2671	172	5	gliomas	glioma	NOUN
fnp-2671	172	6	using	use	VERB
fnp-2671	172	7	csf	csf	NOUN
fnp-2671	172	8	[	[	X
fnp-2671	172	9	16	16	NUM
fnp-2671	172	10	,	,	PUNCT
fnp-2671	172	11	17	17	NUM
fnp-2671	172	12	]	]	PUNCT
fnp-2671	172	13	cancer	cancer	NOUN
fnp-2671	172	14	cells	cell	NOUN
fnp-2671	172	15	release	release	VERB
fnp-2671	172	16	nucleic	nucleic	ADJ
fnp-2671	172	17	acids	acid	NOUN
fnp-2671	172	18	,	,	PUNCT
fnp-2671	172	19	vesicles	vesicle	NOUN
fnp-2671	172	20	,	,	PUNCT
fnp-2671	172	21	proteins	protein	NOUN
fnp-2671	172	22	,	,	PUNCT
fnp-2671	172	23	and	and	CCONJ
fnp-2671	172	24	other	other	ADJ
fnp-2671	172	25	components	component	NOUN
fnp-2671	172	26	into	into	ADP
fnp-2671	172	27	the	the	DET
fnp-2671	172	28	blood	blood	NOUN
fnp-2671	172	29	stream	stream	NOUN
fnp-2671	172	30	and	and	CCONJ
fnp-2671	172	31	other	other	ADJ
fnp-2671	172	32	body	body	NOUN
fnp-2671	172	33	fluids	fluid	NOUN
fnp-2671	172	34	.	.	PUNCT
fnp-2671	173	1	already	already	ADV
fnp-2671	173	2	for	for	ADP
fnp-2671	173	3	quite	quite	DET
fnp-2671	173	4	some	some	DET
fnp-2671	173	5	time	time	NOUN
fnp-2671	173	6	,	,	PUNCT
fnp-2671	173	7	circulating	circulate	VERB
fnp-2671	173	8	tumor	tumor	NOUN
fnp-2671	173	9	dna	dna	NOUN
fnp-2671	173	10	(	(	PUNCT
fnp-2671	173	11	ctdna	ctdna	NOUN
fnp-2671	173	12	)	)	PUNCT
fnp-2671	173	13	in	in	ADP
fnp-2671	173	14	blood	blood	NOUN
fnp-2671	173	15	is	be	AUX
fnp-2671	173	16	considered	consider	VERB
fnp-2671	173	17	as	as	ADP
fnp-2671	173	18	an	an	DET
fnp-2671	173	19	easily	easily	ADV
fnp-2671	173	20	accessible	accessible	ADJ
fnp-2671	173	21	source	source	NOUN
fnp-2671	173	22	of	of	ADP
fnp-2671	173	23	potentially	potentially	ADV
fnp-2671	173	24	very	very	ADV
fnp-2671	173	25	useful	useful	ADJ
fnp-2671	173	26	diagnostic	diagnostic	ADJ
fnp-2671	173	27	,	,	PUNCT
fnp-2671	173	28	prognostic	prognostic	ADJ
fnp-2671	173	29	and/or	and/or	CCONJ
fnp-2671	173	30	predictive	predictive	ADJ
fnp-2671	173	31	information	information	NOUN
fnp-2671	173	32	that	that	PRON
fnp-2671	173	33	can	can	AUX
fnp-2671	173	34	be	be	AUX
fnp-2671	173	35	used	use	VERB
fnp-2671	173	36	to	to	PART
fnp-2671	173	37	improve	improve	VERB
fnp-2671	173	38	the	the	DET
fnp-2671	173	39	management	management	NOUN
fnp-2671	173	40	of	of	ADP
fnp-2671	173	41	cancer	cancer	NOUN
fnp-2671	173	42	patients	patient	NOUN
fnp-2671	173	43	[	[	X
fnp-2671	173	44	48	48	NUM
fnp-2671	173	45	]	]	PUNCT
fnp-2671	173	46	.	.	PUNCT
fnp-2671	174	1	so	so	ADV
fnp-2671	174	2	far	far	ADV
fnp-2671	174	3	,	,	PUNCT
fnp-2671	174	4	however	however	ADV
fnp-2671	174	5	,	,	PUNCT
fnp-2671	174	6	liquid	liquid	ADJ
fnp-2671	174	7	biopsy	biopsy	NOUN
fnp-2671	174	8	diagnosis	diagnosis	NOUN
fnp-2671	174	9	for	for	ADP
fnp-2671	174	10	detection	detection	NOUN
fnp-2671	174	11	and	and	CCONJ
fnp-2671	174	12	monitoring	monitoring	NOUN
fnp-2671	174	13	of	of	ADP
fnp-2671	174	14	patients	patient	NOUN
fnp-2671	174	15	with	with	ADP
fnp-2671	174	16	gliomas	glioma	NOUN
fnp-2671	174	17	has	have	AUX
fnp-2671	174	18	not	not	PART
fnp-2671	174	19	yet	yet	ADV
fnp-2671	174	20	entered	enter	VERB
fnp-2671	174	21	the	the	DET
fnp-2671	174	22	clinic	clinic	NOUN
fnp-2671	174	23	.	.	PUNCT
fnp-2671	175	1	part	part	NOUN
fnp-2671	175	2	of	of	ADP
fnp-2671	175	3	the	the	DET
fnp-2671	175	4	problem	problem	NOUN
fnp-2671	175	5	may	may	AUX
fnp-2671	175	6	be	be	AUX
fnp-2671	175	7	that	that	SCONJ
fnp-2671	175	8	,	,	PUNCT
fnp-2671	175	9	compared	compare	VERB
fnp-2671	175	10	to	to	ADP
fnp-2671	175	11	other	other	ADJ
fnp-2671	175	12	cancers	cancer	NOUN
fnp-2671	175	13	,	,	PUNCT
fnp-2671	175	14	gliomas	glioma	NOUN
fnp-2671	175	15	release	release	VERB
fnp-2671	175	16	relatively	relatively	ADV
fnp-2671	175	17	limited	limited	ADJ
fnp-2671	175	18	amounts	amount	NOUN
fnp-2671	175	19	of	of	ADP
fnp-2671	175	20	ctdna	ctdna	NOUN
fnp-2671	175	21	into	into	ADP
fnp-2671	175	22	the	the	DET
fnp-2671	175	23	bloodstream	bloodstream	NOUN
fnp-2671	175	24	[	[	X
fnp-2671	175	25	49	49	NUM
fnp-2671	175	26	]	]	PUNCT
fnp-2671	175	27	.	.	PUNCT
fnp-2671	176	1	sequencing	sequence	VERB
fnp-2671	176	2	of	of	ADP
fnp-2671	176	3	ctdna	ctdna	NOUN
fnp-2671	176	4	from	from	ADP
fnp-2671	176	5	the	the	DET
fnp-2671	176	6	cerebrospinal	cerebrospinal	ADJ
fnp-2671	176	7	fluid	fluid	NOUN
fnp-2671	176	8	(	(	PUNCT
fnp-2671	176	9	csf	csf	NOUN
fnp-2671	176	10	)	)	PUNCT
fnp-2671	176	11	may	may	AUX
fnp-2671	176	12	provide	provide	VERB
fnp-2671	176	13	an	an	DET
fnp-2671	176	14	alternative	alternative	ADJ
fnp-2671	176	15	way	way	NOUN
fnp-2671	176	16	to	to	PART
fnp-2671	176	17	diagnose	diagnose	VERB
fnp-2671	176	18	glial	glial	ADJ
fnp-2671	176	19	and	and	CCONJ
fnp-2671	176	20	other	other	ADJ
fnp-2671	176	21	cns	cns	PROPN
fnp-2671	176	22	tumors	tumor	NOUN
fnp-2671	176	23	.	.	PUNCT
fnp-2671	177	1	indeed	indeed	ADV
fnp-2671	177	2	,	,	PUNCT
fnp-2671	177	3	in	in	ADP
fnp-2671	177	4	42	42	NUM
fnp-2671	177	5	out	out	ADP
fnp-2671	177	6	of	of	ADP
fnp-2671	177	7	85	85	NUM
fnp-2671	177	8	adult	adult	NOUN
fnp-2671	177	9	patients	patient	NOUN
fnp-2671	177	10	with	with	ADP
fnp-2671	177	11	diffuse	diffuse	ADJ
fnp-2671	177	12	glioma	glioma	NOUN
fnp-2671	177	13	(	(	PUNCT
fnp-2671	177	14	49.4	49.4	NUM
fnp-2671	177	15	%	%	NOUN
fnp-2671	177	16	)	)	PUNCT
fnp-2671	177	17	,	,	PUNCT
fnp-2671	177	18	miller	miller	PROPN
fnp-2671	177	19	et	et	PROPN
fnp-2671	177	20	al	al	PROPN
fnp-2671	177	21	detected	detect	VERB
fnp-2671	177	22	ctdna	ctdna	NOUN
fnp-2671	177	23	in	in	ADP
fnp-2671	177	24	csf	csf	PROPN
fnp-2671	177	25	that	that	PRON
fnp-2671	177	26	was	be	AUX
fnp-2671	177	27	obtained	obtain	VERB
fnp-2671	177	28	by	by	ADP
fnp-2671	177	29	lumbar	lumbar	NOUN
fnp-2671	177	30	puncture	puncture	NOUN
fnp-2671	178	1	[	[	X
fnp-2671	178	2	16	16	NUM
fnp-2671	178	3	]	]	PUNCT
fnp-2671	178	4	.	.	PUNCT
fnp-2671	179	1	presence	presence	NOUN
fnp-2671	179	2	of	of	ADP
fnp-2671	179	3	ctdna	ctdna	NOUN
fnp-2671	179	4	was	be	AUX
fnp-2671	179	5	associated	associate	VERB
fnp-2671	179	6	with	with	ADP
fnp-2671	179	7	disease	disease	NOUN
fnp-2671	179	8	burden	burden	NOUN
fnp-2671	179	9	and	and	CCONJ
fnp-2671	179	10	adverse	adverse	ADJ
fnp-2671	179	11	outcome	outcome	NOUN
fnp-2671	179	12	.	.	PUNCT
fnp-2671	180	1	the	the	DET
fnp-2671	180	2	glioma	glioma	NOUN
fnp-2671	180	3	genomes	genome	NOUN
fnp-2671	180	4	detected	detect	VERB
fnp-2671	180	5	in	in	ADP
fnp-2671	180	6	csf	csf	NOUN
fnp-2671	180	7	closely	closely	ADV
fnp-2671	180	8	resembled	resemble	VERB
fnp-2671	180	9	those	those	PRON
fnp-2671	180	10	in	in	ADP
fnp-2671	180	11	matched	match	VERB
fnp-2671	180	12	tumor	tumor	NOUN
fnp-2671	180	13	samples	sample	NOUN
fnp-2671	180	14	.	.	PUNCT
fnp-2671	181	1	alterations	alteration	NOUN
fnp-2671	181	2	occurring	occur	VERB
fnp-2671	181	3	early	early	ADV
fnp-2671	181	4	in	in	ADP
fnp-2671	181	5	gliomagenesis	gliomagenesis	NOUN
fnp-2671	181	6	(	(	PUNCT
fnp-2671	181	7	idh1	idh1	PROPN
fnp-2671	181	8	/	/	SYM
fnp-2671	181	9	idh2	idh2	PROPN
fnp-2671	181	10	mutation	mutation	PROPN
fnp-2671	181	11	,	,	PUNCT
fnp-2671	181	12	1p/19q	1p/19q	PROPN
fnp-2671	181	13	codeletion	codeletion	NOUN
fnp-2671	181	14	)	)	PUNCT
fnp-2671	181	15	were	be	AUX
fnp-2671	181	16	shared	share	VERB
fnp-2671	181	17	in	in	ADP
fnp-2671	181	18	all	all	DET
fnp-2671	181	19	matched	match	VERB
fnp-2671	181	20	ctdna	ctdna	NOUN
fnp-2671	181	21	-	-	PUNCT
fnp-2671	181	22	positive	positive	ADJ
fnp-2671	181	23	csf	csf	ADJ
fnp-2671	181	24	-	-	ADJ
fnp-2671	181	25	tumor	tumor	NOUN
fnp-2671	181	26	pairs	pair	NOUN
fnp-2671	181	27	,	,	PUNCT
fnp-2671	181	28	whereas	whereas	SCONJ
fnp-2671	181	29	growth	growth	NOUN
fnp-2671	181	30	factor	factor	NOUN
fnp-2671	181	31	receptor	receptor	NOUN
fnp-2671	181	32	signaling	signal	VERB
fnp-2671	181	33	pathways	pathway	NOUN
fnp-2671	181	34	showed	show	VERB
fnp-2671	181	35	considerable	considerable	ADJ
fnp-2671	181	36	evolution	evolution	NOUN
fnp-2671	181	37	.	.	PUNCT
fnp-2671	182	1	most	most	ADJ
fnp-2671	182	2	patients	patient	NOUN
fnp-2671	182	3	with	with	ADP
fnp-2671	182	4	ctdna	ctdna	NOUN
fnp-2671	182	5	-	-	PUNCT
fnp-2671	182	6	positive	positive	ADJ
fnp-2671	182	7	csf	csf	NOUN
fnp-2671	182	8	did	do	AUX
fnp-2671	182	9	not	not	PART
fnp-2671	182	10	have	have	VERB
fnp-2671	182	11	detectable	detectable	ADJ
fnp-2671	182	12	malignant	malignant	ADJ
fnp-2671	182	13	cells	cell	NOUN
fnp-2671	182	14	in	in	ADP
fnp-2671	182	15	the	the	DET
fnp-2671	182	16	csf	csf	NOUN
fnp-2671	182	17	,	,	PUNCT
fnp-2671	182	18	and	and	CCONJ
fnp-2671	182	19	no	no	DET
fnp-2671	182	20	significant	significant	ADJ
fnp-2671	182	21	association	association	NOUN
fnp-2671	182	22	was	be	AUX
fnp-2671	182	23	found	find	VERB
fnp-2671	182	24	between	between	ADP
fnp-2671	182	25	ctdna	ctdna	NOUN
fnp-2671	182	26	-	-	PUNCT
fnp-2671	182	27	positive	positive	ADJ
fnp-2671	182	28	csf	csf	NOUN
fnp-2671	182	29	and	and	CCONJ
fnp-2671	182	30	glioma	glioma	ADJ
fnp-2671	182	31	grade	grade	NOUN
fnp-2671	182	32	,	,	PUNCT
fnp-2671	182	33	disease	disease	NOUN
fnp-2671	182	34	duration	duration	NOUN
fnp-2671	182	35	or	or	CCONJ
fnp-2671	182	36	prior	prior	ADJ
fnp-2671	182	37	therapy	therapy	NOUN
fnp-2671	182	38	.	.	PUNCT
fnp-2671	183	1	of	of	ADP
fnp-2671	183	2	note	note	NOUN
fnp-2671	183	3	,	,	PUNCT
fnp-2671	183	4	in	in	ADP
fnp-2671	183	5	this	this	DET
fnp-2671	183	6	study	study	NOUN
fnp-2671	183	7	of	of	ADP
fnp-2671	183	8	miller	miller	PROPN
fnp-2671	183	9	et	et	PROPN
fnp-2671	183	10	al	al	PROPN
fnp-2671	183	11	the	the	DET
fnp-2671	183	12	csf	csf	ADJ
fnp-2671	183	13	samples	sample	NOUN
fnp-2671	183	14	were	be	AUX
fnp-2671	183	15	derived	derive	VERB
fnp-2671	183	16	from	from	ADP
fnp-2671	183	17	patients	patient	NOUN
fnp-2671	183	18	relatively	relatively	ADV
fnp-2671	183	19	late	late	ADV
fnp-2671	183	20	in	in	ADP
fnp-2671	183	21	their	their	PRON
fnp-2671	183	22	disease	disease	NOUN
fnp-2671	183	23	course	course	NOUN
fnp-2671	183	24	(	(	PUNCT
fnp-2671	183	25	median	median	ADJ
fnp-2671	183	26	disease	disease	NOUN
fnp-2671	183	27	duration	duration	NOUN
fnp-2671	183	28	before	before	ADP
fnp-2671	183	29	csf	csf	ADJ
fnp-2671	183	30	collection	collection	NOUN
fnp-2671	183	31	for	for	ADP
fnp-2671	183	32	patients	patient	NOUN
fnp-2671	183	33	with	with	ADP
fnp-2671	183	34	idh	idh	NOUN
fnp-2671	183	35	-	-	PUNCT
fnp-2671	183	36	wildtype	wildtype	NOUN
fnp-2671	183	37	glioblastomas	glioblastoma	NOUN
fnp-2671	183	38	about	about	ADP
fnp-2671	183	39	a	a	DET
fnp-2671	183	40	year	year	NOUN
fnp-2671	183	41	,	,	PUNCT
fnp-2671	183	42	and	and	CCONJ
fnp-2671	183	43	for	for	ADP
fnp-2671	183	44	patients	patient	NOUN
fnp-2671	183	45	with	with	ADP
fnp-2671	183	46	idh	idh	NOUN
fnp-2671	183	47	-	-	PUNCT
fnp-2671	183	48	mutant	mutant	NOUN
fnp-2671	183	49	lower	low	ADJ
fnp-2671	183	50	grade	grade	NOUN
fnp-2671	183	51	gliomas	glioma	NOUN
fnp-2671	183	52	over	over	ADP
fnp-2671	183	53	5	5	NUM
fnp-2671	183	54	years	year	NOUN
fnp-2671	183	55	)	)	PUNCT
fnp-2671	183	56	,	,	PUNCT
fnp-2671	183	57	and	and	CCONJ
fnp-2671	183	58	all	all	DET
fnp-2671	183	59	patients	patient	NOUN
fnp-2671	183	60	already	already	ADV
fnp-2671	183	61	had	have	VERB
fnp-2671	183	62	treatment	treatment	NOUN
fnp-2671	183	63	for	for	ADP
fnp-2671	183	64	their	their	PRON
fnp-2671	183	65	glial	glial	ADJ
fnp-2671	183	66	tumor	tumor	NOUN
fnp-2671	183	67	.	.	PUNCT
fnp-2671	184	1	in	in	ADP
fnp-2671	184	2	contrast	contrast	NOUN
fnp-2671	184	3	,	,	PUNCT
fnp-2671	184	4	pan	pan	PROPN
fnp-2671	184	5	et	et	PROPN
fnp-2671	184	6	al	al	PROPN
fnp-2671	184	7	explored	explore	VERB
fnp-2671	184	8	the	the	DET
fnp-2671	184	9	potential	potential	NOUN
fnp-2671	184	10	of	of	ADP
fnp-2671	184	11	ctdna	ctdna	NOUN
fnp-2671	184	12	analysis	analysis	NOUN
fnp-2671	184	13	in	in	ADP
fnp-2671	184	14	csf	csf	NOUN
fnp-2671	184	15	obtained	obtain	VERB
fnp-2671	184	16	prior	prior	ADV
fnp-2671	184	17	to	to	ADP
fnp-2671	184	18	surgical	surgical	ADJ
fnp-2671	184	19	manipulation	manipulation	NOUN
fnp-2671	184	20	in	in	ADP
fnp-2671	184	21	a	a	DET
fnp-2671	184	22	cohort	cohort	NOUN
fnp-2671	184	23	of	of	ADP
fnp-2671	184	24	57	57	NUM
fnp-2671	184	25	patients	patient	NOUN
fnp-2671	184	26	with	with	ADP
fnp-2671	184	27	brainstem	brainstem	NOUN
fnp-2671	184	28	glioma	glioma	NOUN
fnp-2671	184	29	[	[	X
fnp-2671	184	30	17	17	NUM
fnp-2671	184	31	]	]	PUNCT
fnp-2671	184	32	.	.	PUNCT
fnp-2671	185	1	over	over	ADP
fnp-2671	185	2	90	90	NUM
fnp-2671	185	3	%	%	NOUN
fnp-2671	185	4	of	of	ADP
fnp-2671	185	5	these	these	DET
fnp-2671	185	6	csf	csf	ADJ
fnp-2671	185	7	samples	sample	NOUN
fnp-2671	185	8	were	be	AUX
fnp-2671	185	9	obtained	obtain	VERB
fnp-2671	185	10	intraoperatively	intraoperatively	ADV
fnp-2671	185	11	.	.	PUNCT
fnp-2671	186	1	pan	pan	PROPN
fnp-2671	186	2	et	et	PROPN
fnp-2671	186	3	al	al	PROPN
fnp-2671	186	4	report	report	VERB
fnp-2671	186	5	that	that	SCONJ
fnp-2671	186	6	alterations	alteration	NOUN
fnp-2671	186	7	were	be	AUX
fnp-2671	186	8	identified	identify	VERB
fnp-2671	186	9	in	in	ADP
fnp-2671	186	10	the	the	DET
fnp-2671	186	11	csf	csf	ADJ
fnp-2671	186	12	ctdna	ctdna	NOUN
fnp-2671	186	13	in	in	ADP
fnp-2671	186	14	36/37	36/37	NUM
fnp-2671	186	15	cases	case	NOUN
fnp-2671	186	16	(	(	PUNCT
fnp-2671	186	17	97.3	97.3	NUM
fnp-2671	186	18	%	%	NOUN
fnp-2671	186	19	)	)	PUNCT
fnp-2671	186	20	in	in	ADP
fnp-2671	186	21	which	which	PRON
fnp-2671	186	22	the	the	DET
fnp-2671	186	23	primary	primary	ADJ
fnp-2671	186	24	tumors	tumor	NOUN
fnp-2671	186	25	harbored	harbor	VERB
fnp-2671	186	26	at	at	ADP
fnp-2671	186	27	least	least	ADV
fnp-2671	186	28	one	one	NUM
fnp-2671	186	29	mutation	mutation	NOUN
fnp-2671	186	30	,	,	PUNCT
fnp-2671	186	31	while	while	SCONJ
fnp-2671	186	32	in	in	ADP
fnp-2671	186	33	31/37	31/37	NUM
fnp-2671	186	34	of	of	ADP
fnp-2671	186	35	cases	case	NOUN
fnp-2671	186	36	(	(	PUNCT
fnp-2671	186	37	83	83	NUM
fnp-2671	186	38	%	%	NOUN
fnp-2671	186	39	)	)	PUNCT
fnp-2671	186	40	all	all	DET
fnp-2671	186	41	primary	primary	ADJ
fnp-2671	186	42	tumor	tumor	NOUN
fnp-2671	186	43	alterations	alteration	NOUN
fnp-2671	186	44	were	be	AUX
fnp-2671	186	45	detected	detect	VERB
fnp-2671	186	46	in	in	ADP
fnp-2671	186	47	the	the	DET
fnp-2671	186	48	csf	csf	NOUN
fnp-2671	186	49	.	.	PROPN
fnp-2671	187	1	in	in	ADP
fnp-2671	187	2	these	these	DET
fnp-2671	187	3	patients	patient	NOUN
fnp-2671	187	4	,	,	PUNCT
fnp-2671	187	5	mutation	mutation	NOUN
fnp-2671	187	6	detection	detection	NOUN
fnp-2671	187	7	using	use	VERB
fnp-2671	187	8	plasma	plasma	NOUN
fnp-2671	187	9	ctdna	ctdna	NOUN
fnp-2671	187	10	was	be	AUX
fnp-2671	187	11	found	find	VERB
fnp-2671	187	12	to	to	PART
fnp-2671	187	13	be	be	AUX
fnp-2671	187	14	much	much	ADV
fnp-2671	187	15	less	less	ADV
fnp-2671	187	16	sensitive	sensitive	ADJ
fnp-2671	187	17	than	than	ADP
fnp-2671	187	18	sequencing	sequence	VERB
fnp-2671	187	19	the	the	DET
fnp-2671	187	20	csf	csf	ADJ
fnp-2671	187	21	ctdna	ctdna	NOUN
fnp-2671	187	22	.	.	PUNCT
fnp-2671	188	1	these	these	DET
fnp-2671	188	2	studies	study	NOUN
fnp-2671	188	3	thus	thus	ADV
fnp-2671	188	4	suggest	suggest	VERB
fnp-2671	188	5	that	that	SCONJ
fnp-2671	188	6	indeed	indeed	ADV
fnp-2671	188	7	csf	csf	X
fnp-2671	188	8	may	may	AUX
fnp-2671	188	9	be	be	AUX
fnp-2671	188	10	a	a	DET
fnp-2671	188	11	much	much	ADV
fnp-2671	188	12	more	more	ADV
fnp-2671	188	13	promising	promising	ADJ
fnp-2671	188	14	biosource	biosource	NOUN
fnp-2671	188	15	for	for	ADP
fnp-2671	188	16	liquid	liquid	ADJ
fnp-2671	188	17	biopsy	biopsy	NOUN
fnp-2671	188	18	diagnostics	diagnostic	NOUN
fnp-2671	188	19	of	of	ADP
fnp-2671	188	20	gliomas	glioma	NOUN
fnp-2671	188	21	than	than	ADP
fnp-2671	188	22	blood	blood	NOUN
fnp-2671	188	23	.	.	PUNCT
fnp-2671	189	1	combination	combination	NOUN
fnp-2671	189	2	of	of	ADP
fnp-2671	189	3	such	such	DET
fnp-2671	189	4	an	an	DET
fnp-2671	189	5	approach	approach	NOUN
fnp-2671	189	6	with	with	ADP
fnp-2671	189	7	analyses	analysis	NOUN
fnp-2671	189	8	going	go	VERB
fnp-2671	189	9	beyond	beyond	ADP
fnp-2671	189	10	dna	dna	PROPN
fnp-2671	189	11	sequence	sequence	NOUN
fnp-2671	189	12	information	information	NOUN
fnp-2671	189	13	(	(	PUNCT
fnp-2671	189	14	e.g.	e.g.	ADV
fnp-2671	189	15	analysis	analysis	NOUN
fnp-2671	189	16	of	of	ADP
fnp-2671	189	17	epigenetic	epigenetic	ADJ
fnp-2671	189	18	and	and	CCONJ
fnp-2671	189	19	immune	immune	ADJ
fnp-2671	189	20	signatures	signature	NOUN
fnp-2671	189	21	in	in	ADP
fnp-2671	189	22	cell	cell	NOUN
fnp-2671	189	23	free	free	ADJ
fnp-2671	189	24	dna	dna	PROPN
fnp-2671	189	25	)	)	PUNCT
fnp-2671	189	26	may	may	AUX
fnp-2671	189	27	further	far	ADV
fnp-2671	189	28	boost	boost	VERB
fnp-2671	189	29	the	the	DET
fnp-2671	189	30	exploitation	exploitation	NOUN
fnp-2671	189	31	of	of	ADP
fnp-2671	189	32	liquid	liquid	ADJ
fnp-2671	189	33	biopsy	biopsy	NOUN
fnp-2671	189	34	diagnostics	diagnostic	NOUN
fnp-2671	189	35	in	in	ADP
fnp-2671	189	36	patients	patient	NOUN
fnp-2671	189	37	with	with	ADP
fnp-2671	189	38	(	(	PUNCT
fnp-2671	189	39	glial	glial	ADJ
fnp-2671	189	40	)	)	PUNCT
fnp-2671	189	41	cns	cns	NOUN
fnp-2671	189	42	tumors	tumor	NOUN
fnp-2671	190	1	[	[	X
fnp-2671	190	2	49	49	NUM
fnp-2671	190	3	]	]	PUNCT
fnp-2671	190	4	.	.	PUNCT
fnp-2671	191	1	discussion	discussion	NOUN
fnp-2671	191	2	the	the	DET
fnp-2671	191	3	papers	paper	NOUN
fnp-2671	191	4	discussed	discuss	VERB
fnp-2671	191	5	in	in	ADP
fnp-2671	191	6	this	this	DET
fnp-2671	191	7	review	review	NOUN
fnp-2671	191	8	as	as	SCONJ
fnp-2671	191	9	top	top	ADJ
fnp-2671	191	10	10	10	NUM
fnp-2671	191	11	discoveries	discovery	NOUN
fnp-2671	191	12	illustrate	illustrate	VERB
fnp-2671	191	13	the	the	DET
fnp-2671	191	14	substantial	substantial	ADJ
fnp-2671	191	15	and	and	CCONJ
fnp-2671	191	16	sometimes	sometimes	ADV
fnp-2671	191	17	even	even	ADV
fnp-2671	191	18	amazing	amazing	ADJ
fnp-2671	191	19	progress	progress	NOUN
fnp-2671	191	20	that	that	PRON
fnp-2671	191	21	has	have	AUX
fnp-2671	191	22	been	be	AUX
fnp-2671	191	23	made	make	VERB
fnp-2671	191	24	in	in	ADP
fnp-2671	191	25	increasing	increase	VERB
fnp-2671	191	26	our	our	PRON
fnp-2671	191	27	understanding	understanding	NOUN
fnp-2671	191	28	of	of	ADP
fnp-2671	191	29	particular	particular	ADJ
fnp-2671	191	30	topics	topic	NOUN
fnp-2671	191	31	in	in	ADP
fnp-2671	191	32	neuro	neuro	NOUN
fnp-2671	191	33	-	-	PUNCT
fnp-2671	191	34	oncological	oncological	ADJ
fnp-2671	191	35	pathology	pathology	NOUN
fnp-2671	191	36	.	.	PUNCT
fnp-2671	192	1	hopefully	hopefully	ADV
fnp-2671	192	2	,	,	PUNCT
fnp-2671	192	3	this	this	DET
fnp-2671	192	4	review	review	NOUN
fnp-2671	192	5	not	not	PART
fnp-2671	192	6	only	only	ADV
fnp-2671	192	7	provides	provide	VERB
fnp-2671	192	8	easily	easily	ADV
fnp-2671	192	9	digestible	digestible	ADJ
fnp-2671	192	10	information	information	NOUN
fnp-2671	192	11	on	on	ADP
fnp-2671	192	12	the	the	DET
fnp-2671	192	13	topics	topic	NOUN
fnp-2671	192	14	selected	select	VERB
fnp-2671	192	15	by	by	ADP
fnp-2671	192	16	the	the	DET
fnp-2671	192	17	author	author	NOUN
fnp-2671	192	18	,	,	PUNCT
fnp-2671	192	19	but	but	CCONJ
fnp-2671	192	20	also	also	ADV
fnp-2671	192	21	works	work	VERB
fnp-2671	192	22	as	as	ADP
fnp-2671	192	23	a	a	DET
fnp-2671	192	24	stepping	stepping	ADJ
fnp-2671	192	25	stone	stone	NOUN
fnp-2671	192	26	to	to	PART
fnp-2671	192	27	read	read	VERB
fnp-2671	192	28	and	and	CCONJ
fnp-2671	192	29	appreciate	appreciate	VERB
fnp-2671	192	30	the	the	DET
fnp-2671	192	31	original	original	ADJ
fnp-2671	192	32	papers	paper	NOUN
fnp-2671	192	33	that	that	PRON
fnp-2671	192	34	were	be	AUX
fnp-2671	192	35	used	use	VERB
fnp-2671	192	36	as	as	ADP
fnp-2671	192	37	building	build	VERB
fnp-2671	192	38	blocks	block	NOUN
fnp-2671	192	39	for	for	ADP
fnp-2671	192	40	the	the	DET
fnp-2671	192	41	present	present	ADJ
fnp-2671	192	42	manuscript	manuscript	NOUN
fnp-2671	192	43	.	.	PUNCT
fnp-2671	193	1	obviously	obviously	ADV
fnp-2671	193	2	,	,	PUNCT
fnp-2671	193	3	most	most	ADJ
fnp-2671	193	4	of	of	ADP
fnp-2671	193	5	the	the	DET
fnp-2671	193	6	findings	finding	NOUN
fnp-2671	193	7	presented	present	VERB
fnp-2671	193	8	here	here	ADV
fnp-2671	193	9	immediately	immediately	ADV
fnp-2671	193	10	elicit	elicit	VERB
fnp-2671	193	11	next	next	ADJ
fnp-2671	193	12	questions	question	NOUN
fnp-2671	193	13	.	.	PUNCT
fnp-2671	194	1	for	for	ADP
fnp-2671	194	2	example	example	NOUN
fnp-2671	194	3	,	,	PUNCT
fnp-2671	194	4	are	be	AUX
fnp-2671	194	5	the	the	DET
fnp-2671	194	6	findings	finding	NOUN
fnp-2671	194	7	presented	present	VERB
fnp-2671	194	8	by	by	ADP
fnp-2671	194	9	filipski	filipski	PROPN
fnp-2671	194	10	et	et	PROPN
fnp-2671	194	11	al	al	PROPN
fnp-2671	194	12	already	already	ADV
fnp-2671	194	13	‘	'	PUNCT
fnp-2671	194	14	mature	mature	ADJ
fnp-2671	194	15	’	'	PUNCT
fnp-2671	194	16	enough	enough	ADJ
fnp-2671	194	17	to	to	PART
fnp-2671	194	18	be	be	AUX
fnp-2671	194	19	used	use	VERB
fnp-2671	194	20	as	as	ADP
fnp-2671	194	21	surrogate	surrogate	ADJ
fnp-2671	194	22	markers	marker	NOUN
fnp-2671	194	23	for	for	ADP
fnp-2671	194	24	the	the	DET
fnp-2671	194	25	diagnosis	diagnosis	NOUN
fnp-2671	194	26	of	of	ADP
fnp-2671	194	27	(	(	PUNCT
fnp-2671	194	28	anaplastic	anaplastic	ADJ
fnp-2671	194	29	)	)	PUNCT
fnp-2671	194	30	oligodendroglioma	oligodendroglioma	NOUN
fnp-2671	194	31	,	,	PUNCT
fnp-2671	194	32	idh	idh	NOUN
fnp-2671	194	33	-	-	PUNCT
fnp-2671	194	34	mutant	mutant	NOUN
fnp-2671	194	35	and	and	CCONJ
fnp-2671	194	36	1p/19q	1p/19q	NOUN
fnp-2671	194	37	-	-	PUNCT
fnp-2671	194	38	codeleted	codelete	VERB
fnp-2671	194	39	in	in	ADP
fnp-2671	194	40	clinical	clinical	ADJ
fnp-2671	194	41	practice	practice	NOUN
fnp-2671	194	42	?	?	PUNCT
fnp-2671	195	1	and	and	CCONJ
fnp-2671	195	2	while	while	SCONJ
fnp-2671	195	3	wang	wang	PROPN
fnp-2671	195	4	et	et	PROPN
fnp-2671	195	5	al	al	PROPN
fnp-2671	195	6	report	report	VERB
fnp-2671	195	7	that	that	SCONJ
fnp-2671	195	8	the	the	DET
fnp-2671	195	9	notch1	notch1	NOUN
fnp-2671	195	10	-	-	PUNCT
fnp-2671	195	11	sox2	sox2	ADJ
fnp-2671	195	12	positive	positive	ADJ
fnp-2671	195	13	-	-	PUNCT
fnp-2671	195	14	feedback	feedback	NOUN
fnp-2671	195	15	loop	loop	NOUN
fnp-2671	195	16	is	be	AUX
fnp-2671	195	17	an	an	DET
fnp-2671	195	18	important	important	ADJ
fnp-2671	195	19	(	(	PUNCT
fnp-2671	195	20	and	and	CCONJ
fnp-2671	195	21	possibly	possibly	ADV
fnp-2671	195	22	targetable	targetable	ADJ
fnp-2671	195	23	)	)	PUNCT
fnp-2671	195	24	determinant	determinant	ADJ
fnp-2671	195	25	of	of	ADP
fnp-2671	195	26	invasion	invasion	NOUN
fnp-2671	195	27	of	of	ADP
fnp-2671	195	28	glioma	glioma	NOUN
fnp-2671	195	29	cells	cell	NOUN
fnp-2671	195	30	along	along	ADP
fnp-2671	195	31	white	white	ADJ
fnp-2671	195	32	matter	matter	NOUN
fnp-2671	195	33	tracts	tract	NOUN
fnp-2671	195	34	,	,	PUNCT
fnp-2671	195	35	the	the	DET
fnp-2671	195	36	authors	author	NOUN
fnp-2671	195	37	acknowledge	acknowledge	VERB
fnp-2671	195	38	that	that	SCONJ
fnp-2671	195	39	other	other	ADJ
fnp-2671	195	40	mechanisms	mechanism	NOUN
fnp-2671	195	41	as	as	SCONJ
fnp-2671	195	42	discussed	discuss	VERB
fnp-2671	195	43	in	in	ADP
fnp-2671	195	44	topic	topic	NOUN
fnp-2671	195	45	7	7	NUM
fnp-2671	195	46	may	may	AUX
fnp-2671	195	47	be	be	AUX
fnp-2671	195	48	involved	involve	VERB
fnp-2671	195	49	as	as	ADV
fnp-2671	195	50	well	well	ADV
fnp-2671	195	51	.	.	PUNCT
fnp-2671	196	1	but	but	CCONJ
fnp-2671	196	2	then	then	ADV
fnp-2671	196	3	again	again	ADV
fnp-2671	196	4	,	,	PUNCT
fnp-2671	196	5	is	be	AUX
fnp-2671	196	6	synapse	synapse	ADJ
fnp-2671	196	7	formation	formation	NOUN
fnp-2671	196	8	between	between	ADP
fnp-2671	196	9	neuronal	neuronal	ADJ
fnp-2671	196	10	and	and	CCONJ
fnp-2671	196	11	glioma	glioma	NOUN
fnp-2671	196	12	cell	cell	NOUN
fnp-2671	196	13	processes	process	NOUN
fnp-2671	196	14	especially	especially	ADV
fnp-2671	196	15	relevant	relevant	ADJ
fnp-2671	196	16	for	for	ADP
fnp-2671	196	17	the	the	DET
fnp-2671	196	18	invasive	invasive	ADJ
fnp-2671	196	19	front	front	NOUN
fnp-2671	196	20	?	?	PUNCT
fnp-2671	197	1	or	or	CCONJ
fnp-2671	197	2	also	also	ADV
fnp-2671	197	3	for	for	ADP
fnp-2671	197	4	proliferation	proliferation	NOUN
fnp-2671	197	5	of	of	ADP
fnp-2671	197	6	tumor	tumor	NOUN
fnp-2671	197	7	cells	cell	NOUN
fnp-2671	197	8	in	in	ADP
fnp-2671	197	9	the	the	DET
fnp-2671	197	10	highly	highly	ADV
fnp-2671	197	11	cellular	cellular	ADJ
fnp-2671	197	12	center	center	NOUN
fnp-2671	197	13	of	of	ADP
fnp-2671	197	14	glioblastomas	glioblastoma	NOUN
fnp-2671	197	15	where	where	SCONJ
fnp-2671	197	16	neurites	neurite	NOUN
fnp-2671	197	17	can	can	AUX
fnp-2671	197	18	be	be	AUX
fnp-2671	197	19	expected	expect	VERB
fnp-2671	197	20	to	to	PART
fnp-2671	197	21	be	be	AUX
fnp-2671	197	22	(	(	PUNCT
fnp-2671	197	23	much	much	ADJ
fnp-2671	197	24	)	)	PUNCT
fnp-2671	197	25	more	more	ADV
fnp-2671	197	26	scarce	scarce	ADJ
fnp-2671	197	27	?	?	PUNCT
fnp-2671	198	1	what	what	PRON
fnp-2671	198	2	about	about	ADP
fnp-2671	198	3	the	the	DET
fnp-2671	198	4	presence	presence	NOUN
fnp-2671	198	5	of	of	ADP
fnp-2671	198	6	‘	'	PUNCT
fnp-2671	198	7	pseudo	pseudo	NOUN
fnp-2671	198	8	-	-	ADJ
fnp-2671	198	9	tripartite	tripartite	ADJ
fnp-2671	198	10	synapses	synapsis	NOUN
fnp-2671	198	11	’	'	PUNCT
fnp-2671	198	12	in	in	ADP
fnp-2671	198	13	the	the	DET
fnp-2671	198	14	‘	'	PUNCT
fnp-2671	198	15	bulky	bulky	ADJ
fnp-2671	198	16	’	'	PUNCT
fnp-2671	198	17	areas	area	NOUN
fnp-2671	198	18	of	of	ADP
fnp-2671	198	19	metastatic	metastatic	ADJ
fnp-2671	198	20	breast	breast	NOUN
fnp-2671	198	21	cancer	cancer	NOUN
fnp-2671	198	22	in	in	ADP
fnp-2671	198	23	the	the	DET
fnp-2671	198	24	cns	cns	NOUN
fnp-2671	198	25	?	?	PUNCT
fnp-2671	199	1	and	and	CCONJ
fnp-2671	199	2	(	(	PUNCT
fnp-2671	199	3	see	see	VERB
fnp-2671	199	4	topic	topic	NOUN
fnp-2671	199	5	8)	8)	NUM
fnp-2671	199	6	:	:	PUNCT
fnp-2671	199	7	do	do	AUX
fnp-2671	199	8	bona	bona	ADJ
fnp-2671	199	9	fide	fide	ADJ
fnp-2671	199	10	glioma	glioma	NOUN
fnp-2671	199	11	stem	stem	NOUN
fnp-2671	199	12	cells	cell	NOUN
fnp-2671	199	13	exist	exist	VERB
fnp-2671	199	14	?	?	PUNCT
fnp-2671	200	1	nowadays	nowadays	ADV
fnp-2671	200	2	,	,	PUNCT
fnp-2671	200	3	a	a	DET
fnp-2671	200	4	rapidly	rapidly	ADV
fnp-2671	200	5	increasing	increase	VERB
fnp-2671	200	6	number	number	NOUN
fnp-2671	200	7	of	of	ADP
fnp-2671	200	8	diagnostic	diagnostic	ADJ
fnp-2671	200	9	and	and	CCONJ
fnp-2671	200	10	prognostic	prognostic	ADJ
fnp-2671	200	11	molecular	molecular	ADJ
fnp-2671	200	12	markers	marker	NOUN
fnp-2671	200	13	can	can	AUX
fnp-2671	200	14	be	be	AUX
fnp-2671	200	15	used	use	VERB
fnp-2671	200	16	for	for	ADP
fnp-2671	200	17	an	an	DET
fnp-2671	200	18	improved	improve	VERB
fnp-2671	200	19	,	,	PUNCT
fnp-2671	200	20	‘	'	PUNCT
fnp-2671	200	21	histo	histo	ADJ
fnp-2671	200	22	-	-	PUNCT
fnp-2671	200	23	molecular	molecular	ADJ
fnp-2671	200	24	’	'	PUNCT
fnp-2671	200	25	diagnosis	diagnosis	NOUN
fnp-2671	200	26	of	of	ADP
fnp-2671	200	27	cns	cns	NOUN
fnp-2671	200	28	tumors	tumor	NOUN
fnp-2671	201	1	[	[	X
fnp-2671	201	2	50	50	NUM
fnp-2671	201	3	]	]	PUNCT
fnp-2671	201	4	.	.	PUNCT
fnp-2671	202	1	multiple	multiple	ADJ
fnp-2671	202	2	assays	assay	NOUN
fnp-2671	202	3	have	have	AUX
fnp-2671	202	4	been	be	AUX
fnp-2671	202	5	developed	develop	VERB
fnp-2671	202	6	for	for	ADP
fnp-2671	202	7	this	this	DET
fnp-2671	202	8	purpose	purpose	NOUN
fnp-2671	202	9	,	,	PUNCT
fnp-2671	202	10	ranging	range	VERB
fnp-2671	202	11	from	from	ADP
fnp-2671	202	12	single	single	ADJ
fnp-2671	202	13	gene	gene	NOUN
fnp-2671	202	14	tests	test	NOUN
fnp-2671	202	15	to	to	ADP
fnp-2671	202	16	high	high	ADJ
fnp-2671	202	17	-	-	PUNCT
fnp-2671	202	18	throughput	throughput	NOUN
fnp-2671	202	19	,	,	PUNCT
fnp-2671	202	20	integrated	integrate	VERB
fnp-2671	202	21	techniques	technique	NOUN
fnp-2671	202	22	enabling	enable	VERB
fnp-2671	202	23	detection	detection	NOUN
fnp-2671	202	24	of	of	ADP
fnp-2671	202	25	multiple	multiple	ADJ
fnp-2671	202	26	genetic	genetic	ADJ
fnp-2671	202	27	aberrations	aberration	NOUN
fnp-2671	202	28	in	in	ADP
fnp-2671	202	29	a	a	DET
fnp-2671	202	30	single	single	ADJ
fnp-2671	202	31	workflow	workflow	NOUN
fnp-2671	202	32	[	[	X
fnp-2671	202	33	51	51	NUM
fnp-2671	202	34	]	]	PUNCT
fnp-2671	202	35	.	.	PUNCT
fnp-2671	203	1	immunohistochemistry	immunohistochemistry	PROPN
fnp-2671	203	2	is	be	AUX
fnp-2671	203	3	a	a	DET
fnp-2671	203	4	helpful	helpful	ADJ
fnp-2671	203	5	,	,	PUNCT
fnp-2671	203	6	relatively	relatively	ADV
fnp-2671	203	7	inexpensive	inexpensive	ADJ
fnp-2671	203	8	alternative	alternative	NOUN
fnp-2671	203	9	for	for	ADP
fnp-2671	203	10	further	further	ADJ
fnp-2671	203	11	molecular	molecular	ADJ
fnp-2671	203	12	characterization	characterization	NOUN
fnp-2671	203	13	of	of	ADP
fnp-2671	203	14	particular	particular	ADJ
fnp-2671	203	15	cns	cns	NOUN
fnp-2671	203	16	tumors	tumor	NOUN
fnp-2671	203	17	.	.	PUNCT
fnp-2671	204	1	within	within	ADP
fnp-2671	204	2	a	a	DET
fnp-2671	204	3	few	few	ADJ
fnp-2671	204	4	years	year	NOUN
fnp-2671	204	5	after	after	ADP
fnp-2671	204	6	its	its	PRON
fnp-2671	204	7	introduction	introduction	NOUN
fnp-2671	204	8	,	,	PUNCT
fnp-2671	204	9	genome	genome	NOUN
fnp-2671	204	10	-	-	PUNCT
fnp-2671	204	11	wide	wide	ADJ
fnp-2671	204	12	methylation	methylation	NOUN
fnp-2671	204	13	profiling	profiling	NOUN
fnp-2671	204	14	has	have	AUX
fnp-2671	204	15	already	already	ADV
fnp-2671	204	16	had	have	VERB
fnp-2671	204	17	a	a	DET
fnp-2671	204	18	revolutionary	revolutionary	ADJ
fnp-2671	204	19	impact	impact	NOUN
fnp-2671	204	20	on	on	ADP
fnp-2671	204	21	cns	cns	NOUN
fnp-2671	204	22	tumor	tumor	NOUN
fnp-2671	204	23	classification	classification	NOUN
fnp-2671	204	24	[	[	X
fnp-2671	204	25	24	24	NUM
fnp-2671	204	26	,	,	PUNCT
fnp-2671	204	27	25	25	NUM
fnp-2671	204	28	,	,	PUNCT
fnp-2671	204	29	52	52	NUM
fnp-2671	204	30	]	]	PUNCT
fnp-2671	204	31	.	.	PUNCT
fnp-2671	205	1	the	the	DET
fnp-2671	205	2	papers	paper	NOUN
fnp-2671	205	3	discussed	discuss	VERB
fnp-2671	205	4	in	in	ADP
fnp-2671	205	5	topic	topic	NOUN
fnp-2671	205	6	2	2	NUM
fnp-2671	205	7	(	(	PUNCT
fnp-2671	205	8	‘	'	PUNCT
fnp-2671	205	9	improved	improve	VERB
fnp-2671	205	10	molecular	molecular	ADJ
fnp-2671	205	11	diagnosis	diagnosis	NOUN
fnp-2671	205	12	of	of	ADP
fnp-2671	205	13	rare	rare	ADJ
fnp-2671	205	14	cns	cns	NOUN
fnp-2671	205	15	tumor	tumor	NOUN
fnp-2671	205	16	types	type	NOUN
fnp-2671	205	17	’	'	PUNCT
fnp-2671	205	18	)	)	PUNCT
fnp-2671	205	19	provide	provide	VERB
fnp-2671	205	20	examples	example	NOUN
fnp-2671	205	21	of	of	ADP
fnp-2671	205	22	the	the	DET
fnp-2671	205	23	strength	strength	NOUN
fnp-2671	205	24	of	of	ADP
fnp-2671	205	25	this	this	DET
fnp-2671	205	26	platform	platform	NOUN
fnp-2671	205	27	.	.	PUNCT
fnp-2671	206	1	however	however	ADV
fnp-2671	206	2	,	,	PUNCT
fnp-2671	206	3	such	such	ADJ
fnp-2671	206	4	methylome	methylome	ADJ
fnp-2671	206	5	analysis	analysis	NOUN
fnp-2671	206	6	is	be	AUX
fnp-2671	206	7	relatively	relatively	ADV
fnp-2671	206	8	expensive	expensive	ADJ
fnp-2671	206	9	.	.	PUNCT
fnp-2671	207	1	obviously	obviously	ADV
fnp-2671	207	2	,	,	PUNCT
fnp-2671	207	3	a	a	DET
fnp-2671	207	4	test	test	NOUN
fnp-2671	207	5	providing	provide	VERB
fnp-2671	207	6	clinically	clinically	ADV
fnp-2671	207	7	very	very	ADV
fnp-2671	207	8	valuable	valuable	ADJ
fnp-2671	207	9	information	information	NOUN
fnp-2671	207	10	at	at	ADP
fnp-2671	207	11	low	low	ADJ
fnp-2671	207	12	costs	cost	NOUN
fnp-2671	207	13	will	will	AUX
fnp-2671	207	14	much	much	ADV
fnp-2671	207	15	more	more	ADV
fnp-2671	207	16	easily	easily	ADV
fnp-2671	207	17	be	be	AUX
fnp-2671	207	18	accepted	accept	VERB
fnp-2671	207	19	as	as	ADP
fnp-2671	207	20	a	a	DET
fnp-2671	207	21	routine	routine	ADJ
fnp-2671	207	22	diagnostic	diagnostic	ADJ
fnp-2671	207	23	tool	tool	NOUN
fnp-2671	207	24	compared	compare	VERB
fnp-2671	207	25	to	to	ADP
fnp-2671	207	26	an	an	DET
fnp-2671	207	27	expensive	expensive	ADJ
fnp-2671	207	28	test	test	NOUN
fnp-2671	207	29	with	with	ADP
fnp-2671	207	30	limited	limited	ADJ
fnp-2671	207	31	clinical	clinical	ADJ
fnp-2671	207	32	benefits	benefit	NOUN
fnp-2671	207	33	.	.	PUNCT
fnp-2671	208	1	unfortunately	unfortunately	ADV
fnp-2671	208	2	,	,	PUNCT
fnp-2671	208	3	a	a	DET
fnp-2671	208	4	clear	clear	ADJ
fnp-2671	208	5	framework	framework	NOUN
fnp-2671	208	6	for	for	ADP
fnp-2671	208	7	assessment	assessment	NOUN
fnp-2671	208	8	of	of	ADP
fnp-2671	208	9	cost	cost	NOUN
fnp-2671	208	10	-	-	PUNCT
fnp-2671	208	11	effectiveness	effectiveness	NOUN
fnp-2671	208	12	of	of	ADP
fnp-2671	208	13	molecular	molecular	ADJ
fnp-2671	208	14	testing	testing	NOUN
fnp-2671	208	15	of	of	ADP
fnp-2671	208	16	cns	cns	NOUN
fnp-2671	208	17	(	(	PUNCT
fnp-2671	208	18	and	and	CCONJ
fnp-2671	208	19	other	other	ADJ
fnp-2671	208	20	)	)	PUNCT
fnp-2671	208	21	tumors	tumor	NOUN
fnp-2671	208	22	is	be	AUX
fnp-2671	208	23	lacking	lack	VERB
fnp-2671	208	24	[	[	X
fnp-2671	208	25	53	53	NUM
fnp-2671	208	26	]	]	PUNCT
fnp-2671	208	27	.	.	PUNCT
fnp-2671	209	1	it	it	PRON
fnp-2671	209	2	is	be	AUX
fnp-2671	209	3	important	important	ADJ
fnp-2671	209	4	to	to	PART
fnp-2671	209	5	realize	realize	VERB
fnp-2671	209	6	though	though	ADV
fnp-2671	209	7	that	that	SCONJ
fnp-2671	209	8	molecular	molecular	ADJ
fnp-2671	209	9	diagnostics	diagnostic	NOUN
fnp-2671	209	10	of	of	ADP
fnp-2671	209	11	(	(	PUNCT
fnp-2671	209	12	cns	cns	NOUN
fnp-2671	209	13	)	)	PUNCT
fnp-2671	209	14	tumors	tumor	NOUN
fnp-2671	209	15	is	be	AUX
fnp-2671	209	16	relatively	relatively	ADV
fnp-2671	209	17	inexpensive	inexpensive	ADJ
fnp-2671	209	18	compared	compare	VERB
fnp-2671	209	19	to	to	ADP
fnp-2671	209	20	e.g.	e.g.	ADV
fnp-2671	209	21	neuro	neuro	NOUN
fnp-2671	209	22	-	-	PUNCT
fnp-2671	209	23	imaging	imaging	NOUN
fnp-2671	209	24	and	and	CCONJ
fnp-2671	209	25	chemotherapy	chemotherapy	NOUN
fnp-2671	209	26	,	,	PUNCT
fnp-2671	209	27	and	and	CCONJ
fnp-2671	209	28	that	that	SCONJ
fnp-2671	209	29	a	a	DET
fnp-2671	209	30	diagnosis	diagnosis	NOUN
fnp-2671	209	31	that	that	PRON
fnp-2671	209	32	is	be	AUX
fnp-2671	209	33	‘	'	PUNCT
fnp-2671	209	34	on	on	ADP
fnp-2671	209	35	target	target	NOUN
fnp-2671	209	36	’	'	PUNCT
fnp-2671	209	37	will	will	AUX
fnp-2671	209	38	not	not	PART
fnp-2671	209	39	only	only	ADV
fnp-2671	209	40	have	have	VERB
fnp-2671	209	41	substantial	substantial	ADJ
fnp-2671	209	42	clinical	clinical	ADJ
fnp-2671	209	43	benefit	benefit	NOUN
fnp-2671	209	44	for	for	ADP
fnp-2671	209	45	the	the	DET
fnp-2671	209	46	patients	patient	NOUN
fnp-2671	209	47	but	but	CCONJ
fnp-2671	209	48	may	may	AUX
fnp-2671	209	49	also	also	ADV
fnp-2671	209	50	help	help	VERB
fnp-2671	209	51	to	to	PART
fnp-2671	209	52	avoid	avoid	VERB
fnp-2671	209	53	unnecessary	unnecessary	ADJ
fnp-2671	209	54	health	health	NOUN
fnp-2671	209	55	care	care	NOUN
fnp-2671	209	56	costs	cost	NOUN
fnp-2671	209	57	[	[	X
fnp-2671	209	58	52	52	NUM
fnp-2671	209	59	,	,	PUNCT
fnp-2671	209	60	54	54	NUM
fnp-2671	209	61	]	]	PUNCT
fnp-2671	209	62	.	.	PUNCT
fnp-2671	210	1	meanwhile	meanwhile	ADV
fnp-2671	210	2	,	,	PUNCT
fnp-2671	210	3	since	since	SCONJ
fnp-2671	210	4	the	the	DET
fnp-2671	210	5	publication	publication	NOUN
fnp-2671	210	6	of	of	ADP
fnp-2671	210	7	the	the	DET
fnp-2671	210	8	who	who	PRON
fnp-2671	210	9	classification	classification	NOUN
fnp-2671	210	10	of	of	ADP
fnp-2671	210	11	cns	cns	PROPN
fnp-2671	210	12	tumours	tumour	NOUN
fnp-2671	210	13	in	in	ADP
fnp-2671	210	14	2016	2016	NUM
fnp-2671	210	15	,	,	PUNCT
fnp-2671	210	16	the	the	DET
fnp-2671	210	17	consortium	consortium	NOUN
fnp-2671	210	18	to	to	PART
fnp-2671	210	19	improve	improve	VERB
fnp-2671	210	20	molecular	molecular	ADJ
fnp-2671	210	21	and	and	CCONJ
fnp-2671	210	22	practical	practical	ADJ
fnp-2671	210	23	approaches	approach	NOUN
fnp-2671	210	24	into	into	ADP
fnp-2671	210	25	cns	cns	PROPN
fnp-2671	210	26	tumor	tumor	NOUN
fnp-2671	210	27	taxonomy	taxonomy	NOUN
fnp-2671	210	28	(	(	PUNCT
fnp-2671	210	29	cimpact	cimpact	VERB
fnp-2671	210	30	-	-	PUNCT
fnp-2671	210	31	now	now	ADV
fnp-2671	210	32	)	)	PUNCT
fnp-2671	210	33	has	have	AUX
fnp-2671	210	34	already	already	ADV
fnp-2671	210	35	published	publish	VERB
fnp-2671	210	36	several	several	ADJ
fnp-2671	210	37	updates	update	NOUN
fnp-2671	210	38	with	with	ADP
fnp-2671	210	39	suggestions	suggestion	NOUN
fnp-2671	210	40	on	on	ADP
fnp-2671	210	41	how	how	SCONJ
fnp-2671	210	42	exactly	exactly	ADV
fnp-2671	210	43	particular	particular	ADJ
fnp-2671	210	44	molecular	molecular	ADJ
fnp-2671	210	45	markers	marker	NOUN
fnp-2671	210	46	can	can	AUX
fnp-2671	210	47	be	be	AUX
fnp-2671	210	48	used	use	VERB
fnp-2671	210	49	for	for	ADP
fnp-2671	210	50	improved	improved	ADJ
fnp-2671	210	51	diagnosis	diagnosis	NOUN
fnp-2671	210	52	in	in	ADP
fnp-2671	210	53	clinical	clinical	ADJ
fnp-2671	210	54	practice	practice	NOUN
fnp-2671	210	55	(	(	PUNCT
fnp-2671	210	56	see	see	VERB
fnp-2671	210	57	for	for	ADP
fnp-2671	210	58	summary	summary	NOUN
fnp-2671	210	59	of	of	ADP
fnp-2671	210	60	round	round	ADJ
fnp-2671	210	61	1	1	NUM
fnp-2671	210	62	updates	update	NOUN
fnp-2671	210	63	[	[	X
fnp-2671	210	64	55	55	NUM
fnp-2671	210	65	]	]	NUM
fnp-2671	210	66	)	)	PUNCT
fnp-2671	210	67	.	.	PUNCT
fnp-2671	211	1	the	the	DET
fnp-2671	211	2	findings	finding	NOUN
fnp-2671	211	3	described	describe	VERB
fnp-2671	211	4	in	in	ADP
fnp-2671	211	5	topic	topic	NOUN
fnp-2671	211	6	3	3	NUM
fnp-2671	211	7	(	(	PUNCT
fnp-2671	211	8	‘	'	PUNCT
fnp-2671	211	9	refined	refined	ADJ
fnp-2671	211	10	molecular	molecular	ADJ
fnp-2671	211	11	classification	classification	NOUN
fnp-2671	211	12	of	of	ADP
fnp-2671	211	13	non	non	NOUN
fnp-2671	211	14	-	-	ADJ
fnp-2671	211	15	wnt	wnt	NOUN
fnp-2671	211	16	/	/	SYM
fnp-2671	211	17	non	non	ADJ
fnp-2671	211	18	-	-	ADJ
fnp-2671	211	19	shh	shh	ADJ
fnp-2671	211	20	medulloblastomas	medulloblastoma	NOUN
fnp-2671	211	21	‘	'	PUNCT
fnp-2671	211	22	)	)	PUNCT
fnp-2671	211	23	and	and	CCONJ
fnp-2671	211	24	topic	topic	NOUN
fnp-2671	211	25	4	4	NUM
fnp-2671	211	26	(	(	PUNCT
fnp-2671	211	27	‘	'	PUNCT
fnp-2671	211	28	histogenesis	histogenesis	NOUN
fnp-2671	211	29	of	of	ADP
fnp-2671	211	30	posterior	posterior	ADJ
fnp-2671	211	31	fossa	fossa	ADJ
fnp-2671	211	32	tumors	tumor	NOUN
fnp-2671	211	33	in	in	ADP
fnp-2671	211	34	children	child	NOUN
fnp-2671	211	35	’	'	PUNCT
fnp-2671	211	36	)	)	PUNCT
fnp-2671	211	37	may	may	AUX
fnp-2671	211	38	soon	soon	ADV
fnp-2671	211	39	be	be	AUX
fnp-2671	211	40	incorporated	incorporate	VERB
fnp-2671	211	41	into	into	ADP
fnp-2671	211	42	a	a	DET
fnp-2671	211	43	more	more	ADV
fnp-2671	211	44	refined	refine	VERB
fnp-2671	211	45	next	next	ADV
fnp-2671	211	46	who	who	PRON
fnp-2671	211	47	classification	classification	NOUN
fnp-2671	211	48	of	of	ADP
fnp-2671	211	49	these	these	DET
fnp-2671	211	50	tumors	tumor	NOUN
fnp-2671	211	51	(	(	PUNCT
fnp-2671	211	52	5th	5th	ADJ
fnp-2671	211	53	edition	edition	NOUN
fnp-2671	211	54	expected	expect	VERB
fnp-2671	211	55	to	to	PART
fnp-2671	211	56	be	be	AUX
fnp-2671	211	57	published	publish	VERB
fnp-2671	211	58	within	within	ADP
fnp-2671	211	59	a	a	DET
fnp-2671	211	60	year	year	NOUN
fnp-2671	211	61	from	from	ADP
fnp-2671	211	62	now	now	ADV
fnp-2671	211	63	!	!	PUNCT
fnp-2671	211	64	)	)	PUNCT
fnp-2671	211	65	.	.	PUNCT
fnp-2671	212	1	when	when	SCONJ
fnp-2671	212	2	shaping	shape	VERB
fnp-2671	212	3	a	a	DET
fnp-2671	212	4	who	who	PRON
fnp-2671	212	5	classification	classification	NOUN
fnp-2671	212	6	,	,	PUNCT
fnp-2671	212	7	one	one	PRON
fnp-2671	212	8	may	may	AUX
fnp-2671	212	9	indeed	indeed	ADV
fnp-2671	212	10	follow	follow	VERB
fnp-2671	212	11	such	such	DET
fnp-2671	212	12	a	a	DET
fnp-2671	212	13	more	more	ADV
fnp-2671	212	14	progressive	progressive	ADJ
fnp-2671	212	15	approach	approach	NOUN
fnp-2671	212	16	(	(	PUNCT
fnp-2671	212	17	i.e.	i.e.	X
fnp-2671	212	18	introduce	introduce	VERB
fnp-2671	212	19	the	the	DET
fnp-2671	212	20	latest	late	ADJ
fnp-2671	212	21	tools	tool	NOUN
fnp-2671	212	22	and	and	CCONJ
fnp-2671	212	23	findings	finding	NOUN
fnp-2671	212	24	and	and	CCONJ
fnp-2671	212	25	include	include	VERB
fnp-2671	212	26	e.g.	e.g.	ADV
fnp-2671	212	27	the	the	DET
fnp-2671	212	28	most	most	ADV
fnp-2671	212	29	refined	refined	ADJ
fnp-2671	212	30	subclassification	subclassification	NOUN
fnp-2671	212	31	of	of	ADP
fnp-2671	212	32	non	non	NOUN
fnp-2671	212	33	-	-	ADJ
fnp-2671	212	34	wnt	wnt	NOUN
fnp-2671	212	35	/	/	SYM
fnp-2671	212	36	non	non	ADJ
fnp-2671	212	37	-	-	ADJ
fnp-2671	212	38	shh	shh	ADJ
fnp-2671	212	39	medulloblastomas	medulloblastoma	NOUN
fnp-2671	212	40	)	)	PUNCT
fnp-2671	212	41	,	,	PUNCT
fnp-2671	212	42	or	or	CCONJ
fnp-2671	212	43	be	be	AUX
fnp-2671	212	44	somewhat	somewhat	ADV
fnp-2671	212	45	more	more	ADV
fnp-2671	212	46	conservative	conservative	ADJ
fnp-2671	212	47	in	in	ADP
fnp-2671	212	48	an	an	DET
fnp-2671	212	49	attempt	attempt	NOUN
fnp-2671	212	50	to	to	PART
fnp-2671	212	51	better	well	ADV
fnp-2671	212	52	preserve	preserve	VERB
fnp-2671	212	53	long	long	ADJ
fnp-2671	212	54	-	-	PUNCT
fnp-2671	212	55	term	term	NOUN
fnp-2671	212	56	correlations	correlation	NOUN
fnp-2671	212	57	,	,	PUNCT
fnp-2671	212	58	to	to	PART
fnp-2671	212	59	avoid	avoid	VERB
fnp-2671	212	60	major	major	ADJ
fnp-2671	212	61	disruption	disruption	NOUN
fnp-2671	212	62	of	of	ADP
fnp-2671	212	63	patient	patient	ADJ
fnp-2671	212	64	management	management	NOUN
fnp-2671	212	65	,	,	PUNCT
fnp-2671	212	66	and/or	and/or	CCONJ
fnp-2671	212	67	because	because	SCONJ
fnp-2671	212	68	of	of	ADP
fnp-2671	212	69	limited	limited	ADJ
fnp-2671	212	70	availability	availability	NOUN
fnp-2671	212	71	of	of	ADP
fnp-2671	212	72	(	(	PUNCT
fnp-2671	212	73	often	often	ADV
fnp-2671	212	74	expensive	expensive	ADJ
fnp-2671	212	75	)	)	PUNCT
fnp-2671	212	76	diagnostic	diagnostic	ADJ
fnp-2671	212	77	tools	tool	NOUN
fnp-2671	212	78	.	.	PUNCT
fnp-2671	213	1	obviously	obviously	ADV
fnp-2671	213	2	,	,	PUNCT
fnp-2671	213	3	finding	find	VERB
fnp-2671	213	4	the	the	DET
fnp-2671	213	5	right	right	ADJ
fnp-2671	213	6	balance	balance	NOUN
fnp-2671	213	7	is	be	AUX
fnp-2671	213	8	key	key	ADJ
fnp-2671	213	9	,	,	PUNCT
fnp-2671	213	10	as	as	SCONJ
fnp-2671	213	11	there	there	PRON
fnp-2671	213	12	are	be	VERB
fnp-2671	213	13	many	many	ADJ
fnp-2671	213	14	‘	'	PUNCT
fnp-2671	213	15	strings	string	NOUN
fnp-2671	213	16	attached	attach	VERB
fnp-2671	213	17	’	'	PUNCT
fnp-2671	213	18	(	(	PUNCT
fnp-2671	213	19	fig	fig	NOUN
fnp-2671	213	20	.	.	PUNCT
fnp-2671	214	1	3	3	NUM
fnp-2671	214	2	)	)	PUNCT
fnp-2671	214	3	.	.	PUNCT
fnp-2671	215	1	fig	fig	NOUN
fnp-2671	215	2	.	.	PUNCT
fnp-2671	216	1	3	3	X
fnp-2671	216	2	.	.	X
fnp-2671	216	3	‘	'	PUNCT
fnp-2671	216	4	strings	string	NOUN
fnp-2671	216	5	attached	attach	VERB
fnp-2671	216	6	’	'	PUNCT
fnp-2671	216	7	to	to	ADP
fnp-2671	216	8	designing	design	VERB
fnp-2671	216	9	a	a	DET
fnp-2671	216	10	next	next	ADJ
fnp-2671	216	11	who	who	PRON
fnp-2671	216	12	classification	classification	NOUN
fnp-2671	216	13	of	of	ADP
fnp-2671	216	14	(	(	PUNCT
fnp-2671	216	15	cns	cns	NOUN
fnp-2671	216	16	)	)	PUNCT
fnp-2671	216	17	tumors	tumor	NOUN
fnp-2671	216	18	.	.	PUNCT
fnp-2671	217	1	finding	find	VERB
fnp-2671	217	2	the	the	DET
fnp-2671	217	3	right	right	ADJ
fnp-2671	217	4	balance	balance	NOUN
fnp-2671	217	5	between	between	ADP
fnp-2671	217	6	a	a	DET
fnp-2671	217	7	conservative	conservative	ADJ
fnp-2671	217	8	and	and	CCONJ
fnp-2671	217	9	progressive	progressive	ADJ
fnp-2671	217	10	attitude	attitude	NOUN
fnp-2671	217	11	with	with	ADP
fnp-2671	217	12	regard	regard	NOUN
fnp-2671	217	13	to	to	ADP
fnp-2671	217	14	incorporating	incorporate	VERB
fnp-2671	217	15	the	the	DET
fnp-2671	217	16	latest	late	ADJ
fnp-2671	217	17	findings	finding	NOUN
fnp-2671	217	18	into	into	ADP
fnp-2671	217	19	a	a	DET
fnp-2671	217	20	next	next	NOUN
fnp-2671	217	21	who	who	PRON
fnp-2671	217	22	tumor	tumor	NOUN
fnp-2671	217	23	classification	classification	NOUN
fnp-2671	217	24	is	be	AUX
fnp-2671	217	25	key	key	ADJ
fnp-2671	217	26	but	but	CCONJ
fnp-2671	217	27	can	can	AUX
fnp-2671	217	28	be	be	AUX
fnp-2671	217	29	challenging	challenging	ADJ
fnp-2671	217	30	,	,	PUNCT
fnp-2671	217	31	not	not	PART
fnp-2671	217	32	only	only	ADV
fnp-2671	217	33	because	because	SCONJ
fnp-2671	217	34	there	there	PRON
fnp-2671	217	35	are	be	VERB
fnp-2671	217	36	many	many	ADJ
fnp-2671	217	37	strings	string	NOUN
fnp-2671	217	38	attached	attach	VERB
fnp-2671	217	39	,	,	PUNCT
fnp-2671	217	40	but	but	CCONJ
fnp-2671	217	41	also	also	ADV
fnp-2671	217	42	because	because	SCONJ
fnp-2671	217	43	of	of	ADP
fnp-2671	217	44	different	different	ADJ
fnp-2671	217	45	aspects	aspect	NOUN
fnp-2671	217	46	of	of	ADP
fnp-2671	217	47	the	the	DET
fnp-2671	217	48	underlying	underlie	VERB
fnp-2671	217	49	dynamics	dynamic	NOUN
fnp-2671	217	50	.	.	PUNCT
fnp-2671	218	1	figure	figure	NOUN
fnp-2671	218	2	based	base	VERB
fnp-2671	218	3	on	on	ADP
fnp-2671	218	4	input	input	NOUN
fnp-2671	218	5	of	of	ADP
fnp-2671	218	6	dr	dr	PROPN
fnp-2671	218	7	.	.	PROPN
fnp-2671	218	8	david	david	PROPN
fnp-2671	218	9	n.	n.	PROPN
fnp-2671	218	10	louis	louis	PROPN
fnp-2671	218	11	.	.	PUNCT
fnp-2671	219	1	next	next	ADJ
fnp-2671	219	2	to	to	ADP
fnp-2671	219	3	diagnostic	diagnostic	ADJ
fnp-2671	219	4	and	and	CCONJ
fnp-2671	219	5	prognostic	prognostic	ADJ
fnp-2671	219	6	markers	marker	NOUN
fnp-2671	219	7	,	,	PUNCT
fnp-2671	219	8	clinical	clinical	ADJ
fnp-2671	219	9	neuropathologists	neuropathologist	NOUN
fnp-2671	219	10	are	be	AUX
fnp-2671	219	11	increasingly	increasingly	ADV
fnp-2671	219	12	asked	ask	VERB
fnp-2671	219	13	to	to	PART
fnp-2671	219	14	perform	perform	VERB
fnp-2671	219	15	testing	testing	NOUN
fnp-2671	219	16	for	for	ADP
fnp-2671	219	17	predictive	predictive	ADJ
fnp-2671	219	18	biomarkers	biomarker	NOUN
fnp-2671	219	19	,	,	PUNCT
fnp-2671	219	20	e.g.	e.g.	ADV
fnp-2671	219	21	for	for	ADP
fnp-2671	219	22	assessment	assessment	NOUN
fnp-2671	219	23	of	of	ADP
fnp-2671	219	24	the	the	DET
fnp-2671	219	25	likelihood	likelihood	NOUN
fnp-2671	219	26	of	of	ADP
fnp-2671	219	27	response	response	NOUN
fnp-2671	219	28	of	of	ADP
fnp-2671	219	29	gliomas	glioma	NOUN
fnp-2671	219	30	to	to	ADP
fnp-2671	219	31	particular	particular	ADJ
fnp-2671	219	32	immunotherapeutic	immunotherapeutic	ADJ
fnp-2671	219	33	approaches	approach	NOUN
fnp-2671	219	34	.	.	PUNCT
fnp-2671	220	1	only	only	ADV
fnp-2671	220	2	a	a	DET
fnp-2671	220	3	limited	limited	ADJ
fnp-2671	220	4	number	number	NOUN
fnp-2671	220	5	of	of	ADP
fnp-2671	220	6	newly	newly	ADV
fnp-2671	220	7	diagnosed	diagnose	VERB
fnp-2671	220	8	gliomas	glioma	NOUN
fnp-2671	220	9	is	be	AUX
fnp-2671	220	10	reported	report	VERB
fnp-2671	220	11	to	to	PART
fnp-2671	220	12	have	have	VERB
fnp-2671	220	13	an	an	DET
fnp-2671	220	14	(	(	PUNCT
fnp-2671	220	15	occasionally	occasionally	ADV
fnp-2671	220	16	inherited	inherit	VERB
fnp-2671	220	17	)	)	PUNCT
fnp-2671	220	18	mismatch	mismatch	NOUN
fnp-2671	220	19	repair	repair	NOUN
fnp-2671	220	20	(	(	PUNCT
fnp-2671	220	21	mmr	mmr	PROPN
fnp-2671	220	22	)	)	PUNCT
fnp-2671	220	23	defect	defect	NOUN
fnp-2671	220	24	and/or	and/or	CCONJ
fnp-2671	220	25	a	a	DET
fnp-2671	220	26	‘	'	PUNCT
fnp-2671	220	27	hypermutator	hypermutator	NOUN
fnp-2671	220	28	’	'	PUNCT
fnp-2671	220	29	phenotype	phenotype	NOUN
fnp-2671	220	30	.	.	PUNCT
fnp-2671	221	1	recurrent	recurrent	ADJ
fnp-2671	221	2	gliomas	glioma	NOUN
fnp-2671	221	3	more	more	ADV
fnp-2671	221	4	often	often	ADV
fnp-2671	221	5	show	show	VERB
fnp-2671	221	6	such	such	DET
fnp-2671	221	7	a	a	DET
fnp-2671	221	8	phenotype	phenotype	NOUN
fnp-2671	221	9	,	,	PUNCT
fnp-2671	221	10	especially	especially	ADV
fnp-2671	221	11	so	so	ADV
fnp-2671	221	12	after	after	ADP
fnp-2671	221	13	alkylating	alkylate	VERB
fnp-2671	221	14	chemotherapy	chemotherapy	NOUN
fnp-2671	221	15	[	[	X
fnp-2671	221	16	8	8	NUM
fnp-2671	221	17	]	]	PUNCT
fnp-2671	221	18	.	.	PUNCT
fnp-2671	222	1	assuming	assume	VERB
fnp-2671	222	2	that	that	SCONJ
fnp-2671	222	3	the	the	DET
fnp-2671	222	4	hypermutator	hypermutator	NOUN
fnp-2671	222	5	status	status	NOUN
fnp-2671	222	6	leads	lead	VERB
fnp-2671	222	7	to	to	ADP
fnp-2671	222	8	an	an	DET
fnp-2671	222	9	increase	increase	NOUN
fnp-2671	222	10	in	in	ADP
fnp-2671	222	11	expression	expression	NOUN
fnp-2671	222	12	of	of	ADP
fnp-2671	222	13	neoantigens	neoantigen	NOUN
fnp-2671	222	14	,	,	PUNCT
fnp-2671	222	15	these	these	DET
fnp-2671	222	16	gliomas	glioma	NOUN
fnp-2671	222	17	/	/	SYM
fnp-2671	222	18	glioblastomas	glioblastoma	NOUN
fnp-2671	222	19	with	with	ADP
fnp-2671	222	20	a	a	DET
fnp-2671	222	21	hypermutator	hypermutator	NOUN
fnp-2671	222	22	phenotype	phenotype	NOUN
fnp-2671	222	23	could	could	AUX
fnp-2671	222	24	be	be	AUX
fnp-2671	222	25	good	good	ADJ
fnp-2671	222	26	candidates	candidate	NOUN
fnp-2671	222	27	for	for	ADP
fnp-2671	222	28	immune	immune	ADJ
fnp-2671	222	29	checkpoint	checkpoint	NOUN
fnp-2671	222	30	blockade	blockade	NOUN
fnp-2671	222	31	.	.	PUNCT
fnp-2671	223	1	unequivocal	unequivocal	ADJ
fnp-2671	223	2	scoring	scoring	NOUN
fnp-2671	223	3	of	of	ADP
fnp-2671	223	4	immunohistochemical	immunohistochemical	ADJ
fnp-2671	223	5	staining	staining	NOUN
fnp-2671	223	6	for	for	ADP
fnp-2671	223	7	pd1	pd1	NOUN
fnp-2671	223	8	/	/	SYM
fnp-2671	223	9	pd	pd	NOUN
fnp-2671	223	10	-	-	PROPN
fnp-2671	223	11	l1	l1	PROPN
fnp-2671	223	12	(	(	PUNCT
fnp-2671	223	13	surface	surface	NOUN
fnp-2671	223	14	proteins	protein	NOUN
fnp-2671	223	15	on	on	ADP
fnp-2671	223	16	tumor	tumor	NOUN
fnp-2671	223	17	-	-	PUNCT
fnp-2671	223	18	infiltrating	infiltrate	VERB
fnp-2671	223	19	lymphocytes	lymphocyte	NOUN
fnp-2671	223	20	and	and	CCONJ
fnp-2671	223	21	tumor	tumor	NOUN
fnp-2671	223	22	cells	cell	NOUN
fnp-2671	223	23	,	,	PUNCT
fnp-2671	223	24	respectively	respectively	ADV
fnp-2671	223	25	,	,	PUNCT
fnp-2671	223	26	and	and	CCONJ
fnp-2671	223	27	involved	involve	VERB
fnp-2671	223	28	in	in	ADP
fnp-2671	223	29	suppression	suppression	NOUN
fnp-2671	223	30	of	of	ADP
fnp-2671	223	31	the	the	DET
fnp-2671	223	32	immune	immune	ADJ
fnp-2671	223	33	system	system	NOUN
fnp-2671	223	34	)	)	PUNCT
fnp-2671	223	35	can	can	AUX
fnp-2671	223	36	be	be	AUX
fnp-2671	223	37	challenging	challenge	VERB
fnp-2671	223	38	.	.	PUNCT
fnp-2671	224	1	alternatively	alternatively	ADV
fnp-2671	224	2	,	,	PUNCT
fnp-2671	224	3	mmr	mmr	NOUN
fnp-2671	224	4	deficiency	deficiency	NOUN
fnp-2671	224	5	,	,	PUNCT
fnp-2671	224	6	microsatellite	microsatellite	ADJ
fnp-2671	224	7	instability	instability	NOUN
fnp-2671	224	8	(	(	PUNCT
fnp-2671	224	9	msi	msi	PROPN
fnp-2671	224	10	)	)	PUNCT
fnp-2671	224	11	,	,	PUNCT
fnp-2671	224	12	dna	dna	PROPN
fnp-2671	224	13	polymerase	polymerase	NOUN
fnp-2671	224	14	epsilon	epsilon	PROPN
fnp-2671	224	15	(	(	PUNCT
fnp-2671	224	16	pole	pole	NOUN
fnp-2671	224	17	)	)	PUNCT
fnp-2671	224	18	mutations	mutation	NOUN
fnp-2671	224	19	,	,	PUNCT
fnp-2671	224	20	and	and	CCONJ
fnp-2671	224	21	high	high	ADJ
fnp-2671	224	22	tumor	tumor	NOUN
fnp-2671	224	23	mutational	mutational	ADJ
fnp-2671	224	24	load	load	NOUN
fnp-2671	224	25	(	(	PUNCT
fnp-2671	224	26	tml	tml	NOUN
fnp-2671	224	27	)	)	PUNCT
fnp-2671	224	28	are	be	AUX
fnp-2671	224	29	being	be	AUX
fnp-2671	224	30	used	use	VERB
fnp-2671	224	31	in	in	ADP
fnp-2671	224	32	this	this	DET
fnp-2671	224	33	context	context	NOUN
fnp-2671	224	34	,	,	PUNCT
fnp-2671	224	35	but	but	CCONJ
fnp-2671	224	36	assessment	assessment	NOUN
fnp-2671	224	37	of	of	ADP
fnp-2671	224	38	these	these	DET
fnp-2671	224	39	biomarkers	biomarker	NOUN
fnp-2671	224	40	can	can	AUX
fnp-2671	224	41	be	be	AUX
fnp-2671	224	42	challenging	challenge	VERB
fnp-2671	224	43	as	as	ADV
fnp-2671	224	44	well	well	ADV
fnp-2671	224	45	.	.	PUNCT
fnp-2671	225	1	for	for	ADP
fnp-2671	225	2	example	example	NOUN
fnp-2671	225	3	,	,	PUNCT
fnp-2671	225	4	mmr	mmr	PROPN
fnp-2671	225	5	gene	gene	NOUN
fnp-2671	225	6	(	(	PUNCT
fnp-2671	225	7	mlh1	mlh1	PROPN
fnp-2671	225	8	,	,	PUNCT
fnp-2671	225	9	msh2	msh2	NOUN
fnp-2671	225	10	,	,	PUNCT
fnp-2671	225	11	msh6	msh6	NOUN
fnp-2671	225	12	,	,	PUNCT
fnp-2671	225	13	and/or	and/or	CCONJ
fnp-2671	225	14	pms2	pms2	PROPN
fnp-2671	225	15	)	)	PUNCT
fnp-2671	225	16	mutations	mutation	NOUN
fnp-2671	225	17	often	often	ADV
fnp-2671	225	18	,	,	PUNCT
fnp-2671	225	19	but	but	CCONJ
fnp-2671	225	20	not	not	PART
fnp-2671	225	21	always	always	ADV
fnp-2671	225	22	lead	lead	VERB
fnp-2671	225	23	to	to	ADP
fnp-2671	225	24	lack	lack	NOUN
fnp-2671	225	25	of	of	ADP
fnp-2671	225	26	immunostaining	immunostaine	VERB
fnp-2671	225	27	of	of	ADP
fnp-2671	225	28	tumor	tumor	NOUN
fnp-2671	225	29	cell	cell	NOUN
fnp-2671	225	30	nuclei	nucleus	NOUN
fnp-2671	225	31	for	for	ADP
fnp-2671	225	32	the	the	DET
fnp-2671	225	33	corresponding	corresponding	ADJ
fnp-2671	225	34	protein(s	protein(s	NOUN
fnp-2671	225	35	)	)	PUNCT
fnp-2671	225	36	.	.	PUNCT
fnp-2671	226	1	also	also	ADV
fnp-2671	226	2	,	,	PUNCT
fnp-2671	226	3	the	the	DET
fnp-2671	226	4	techniques	technique	NOUN
fnp-2671	226	5	and	and	CCONJ
fnp-2671	226	6	thresholds	threshold	NOUN
fnp-2671	226	7	to	to	PART
fnp-2671	226	8	be	be	AUX
fnp-2671	226	9	used	use	VERB
fnp-2671	226	10	for	for	ADP
fnp-2671	226	11	optimal	optimal	ADJ
fnp-2671	226	12	assessment	assessment	NOUN
fnp-2671	226	13	of	of	ADP
fnp-2671	226	14	high	high	ADJ
fnp-2671	226	15	tml	tml	PROPN
fnp-2671	226	16	are	be	AUX
fnp-2671	226	17	not	not	PART
fnp-2671	226	18	yet	yet	ADV
fnp-2671	226	19	settled	settle	VERB
fnp-2671	226	20	.	.	PUNCT
fnp-2671	227	1	while	while	SCONJ
fnp-2671	227	2	for	for	ADP
fnp-2671	227	3	non	non	ADJ
fnp-2671	227	4	-	-	ADJ
fnp-2671	227	5	small	small	ADJ
fnp-2671	227	6	cell	cell	NOUN
fnp-2671	227	7	lung	lung	NOUN
fnp-2671	227	8	carcinoma	carcinoma	NOUN
fnp-2671	227	9	≥10	≥10	ADJ
fnp-2671	227	10	mutations	mutation	NOUN
fnp-2671	227	11	per	per	ADP
fnp-2671	227	12	mb	mb	NOUN
fnp-2671	227	13	is	be	AUX
fnp-2671	227	14	considered	consider	VERB
fnp-2671	227	15	as	as	ADP
fnp-2671	227	16	high	high	ADJ
fnp-2671	227	17	tml	tml	PROPN
fnp-2671	227	18	,	,	PUNCT
fnp-2671	227	19	it	it	PRON
fnp-2671	227	20	is	be	AUX
fnp-2671	227	21	unclear	unclear	ADJ
fnp-2671	227	22	if	if	SCONJ
fnp-2671	227	23	this	this	DET
fnp-2671	227	24	threshold	threshold	NOUN
fnp-2671	227	25	should	should	AUX
fnp-2671	227	26	be	be	AUX
fnp-2671	227	27	used	use	VERB
fnp-2671	227	28	for	for	ADP
fnp-2671	227	29	gliomas	glioma	NOUN
fnp-2671	227	30	as	as	ADV
fnp-2671	227	31	well	well	ADV
fnp-2671	227	32	[	[	X
fnp-2671	227	33	56	56	NUM
fnp-2671	227	34	,	,	PUNCT
fnp-2671	227	35	57	57	NUM
fnp-2671	227	36	]	]	PUNCT
fnp-2671	227	37	.	.	PUNCT
fnp-2671	228	1	of	of	ADP
fnp-2671	228	2	course	course	NOUN
fnp-2671	228	3	,	,	PUNCT
fnp-2671	228	4	identification	identification	NOUN
fnp-2671	228	5	and	and	CCONJ
fnp-2671	228	6	optimization	optimization	NOUN
fnp-2671	228	7	of	of	ADP
fnp-2671	228	8	biomarkers	biomarker	NOUN
fnp-2671	228	9	for	for	ADP
fnp-2671	228	10	response	response	NOUN
fnp-2671	228	11	to	to	ADP
fnp-2671	228	12	immunotherapy	immunotherapy	NOUN
fnp-2671	228	13	only	only	ADV
fnp-2671	228	14	makes	make	VERB
fnp-2671	228	15	sense	sense	NOUN
fnp-2671	228	16	if	if	SCONJ
fnp-2671	228	17	at	at	ADP
fnp-2671	228	18	least	least	ADJ
fnp-2671	228	19	some	some	PRON
fnp-2671	228	20	patients	patient	NOUN
fnp-2671	228	21	can	can	AUX
fnp-2671	228	22	be	be	AUX
fnp-2671	228	23	expected	expect	VERB
fnp-2671	228	24	to	to	PART
fnp-2671	228	25	significantly	significantly	ADV
fnp-2671	228	26	benefit	benefit	VERB
fnp-2671	228	27	from	from	ADP
fnp-2671	228	28	that	that	DET
fnp-2671	228	29	particular	particular	ADJ
fnp-2671	228	30	therapy	therapy	NOUN
fnp-2671	228	31	.	.	PUNCT
fnp-2671	229	1	furthermore	furthermore	ADV
fnp-2671	229	2	,	,	PUNCT
fnp-2671	229	3	the	the	DET
fnp-2671	229	4	studies	study	NOUN
fnp-2671	229	5	reported	report	VERB
fnp-2671	229	6	under	under	ADP
fnp-2671	229	7	topic	topic	NOUN
fnp-2671	229	8	9	9	NUM
fnp-2671	229	9	(	(	PUNCT
fnp-2671	229	10	‘	'	PUNCT
fnp-2671	229	11	personalized	personalized	ADJ
fnp-2671	229	12	(	(	PUNCT
fnp-2671	229	13	neo)antigen	neo)antigen	NOUN
fnp-2671	229	14	vaccination	vaccination	NOUN
fnp-2671	229	15	therapy	therapy	NOUN
fnp-2671	229	16	for	for	ADP
fnp-2671	229	17	glioblastoma	glioblastoma	NOUN
fnp-2671	229	18	’	'	PUNCT
fnp-2671	229	19	)	)	PUNCT
fnp-2671	229	20	indicate	indicate	VERB
fnp-2671	229	21	that	that	DET
fnp-2671	229	22	biomarker	biomarker	NOUN
fnp-2671	229	23	discovery	discovery	NOUN
fnp-2671	229	24	in	in	ADP
fnp-2671	229	25	this	this	DET
fnp-2671	229	26	context	context	NOUN
fnp-2671	229	27	is	be	AUX
fnp-2671	229	28	a	a	DET
fnp-2671	229	29	moving	move	VERB
fnp-2671	229	30	target	target	NOUN
fnp-2671	229	31	.	.	PUNCT
fnp-2671	230	1	in	in	ADP
fnp-2671	230	2	conclusion	conclusion	NOUN
fnp-2671	230	3	,	,	PUNCT
fnp-2671	230	4	‘	'	PUNCT
fnp-2671	230	5	the	the	DET
fnp-2671	230	6	times	time	NOUN
fnp-2671	230	7	they	they	PRON
fnp-2671	230	8	are	be	AUX
fnp-2671	230	9	a	a	DET
fnp-2671	230	10	-	-	PUNCT
fnp-2671	230	11	changin	changin	NOUN
fnp-2671	230	12	’	'	PUNCT
fnp-2671	230	13	and	and	CCONJ
fnp-2671	230	14	one	one	PRON
fnp-2671	230	15	can	can	AUX
fnp-2671	230	16	expect	expect	VERB
fnp-2671	230	17	that	that	SCONJ
fnp-2671	230	18	there	there	PRON
fnp-2671	230	19	is	be	VERB
fnp-2671	230	20	much	much	ADV
fnp-2671	230	21	more	more	ADJ
fnp-2671	230	22	change	change	NOUN
fnp-2671	230	23	to	to	PART
fnp-2671	230	24	come	come	VERB
fnp-2671	230	25	.	.	PUNCT
fnp-2671	231	1	liquid	liquid	ADJ
fnp-2671	231	2	biopsy	biopsy	NOUN
fnp-2671	231	3	-	-	PUNCT
fnp-2671	231	4	based	base	VERB
fnp-2671	231	5	diagnoses	diagnosis	NOUN
fnp-2671	231	6	may	may	AUX
fnp-2671	231	7	emerge	emerge	VERB
fnp-2671	231	8	soon	soon	ADV
fnp-2671	231	9	as	as	ADP
fnp-2671	231	10	a	a	DET
fnp-2671	231	11	clinically	clinically	ADV
fnp-2671	231	12	helpful	helpful	ADJ
fnp-2671	231	13	source	source	NOUN
fnp-2671	231	14	of	of	ADP
fnp-2671	231	15	information	information	NOUN
fnp-2671	231	16	.	.	PUNCT
fnp-2671	232	1	furthermore	furthermore	ADV
fnp-2671	232	2	,	,	PUNCT
fnp-2671	232	3	a	a	DET
fnp-2671	232	4	very	very	ADV
fnp-2671	232	5	recently	recently	ADV
fnp-2671	232	6	published	publish	VERB
fnp-2671	232	7	study	study	NOUN
fnp-2671	232	8	showed	show	VERB
fnp-2671	232	9	that	that	SCONJ
fnp-2671	232	10	the	the	DET
fnp-2671	232	11	use	use	NOUN
fnp-2671	232	12	of	of	ADP
fnp-2671	232	13	artificial	artificial	ADJ
fnp-2671	232	14	intelligence	intelligence	NOUN
fnp-2671	232	15	outperformed	outperform	VERB
fnp-2671	232	16	radiologists	radiologist	NOUN
fnp-2671	232	17	in	in	ADP
fnp-2671	232	18	the	the	DET
fnp-2671	232	19	mammogram	mammogram	NOUN
fnp-2671	232	20	-	-	PUNCT
fnp-2671	232	21	based	base	VERB
fnp-2671	232	22	prediction	prediction	NOUN
fnp-2671	232	23	of	of	ADP
fnp-2671	232	24	breast	breast	NOUN
fnp-2671	232	25	cancer	cancer	NOUN
fnp-2671	232	26	[	[	X
fnp-2671	232	27	58	58	NUM
fnp-2671	232	28	]	]	PUNCT
fnp-2671	232	29	.	.	PUNCT
fnp-2671	233	1	similarly	similarly	ADV
fnp-2671	233	2	,	,	PUNCT
fnp-2671	233	3	deep	deep	ADJ
fnp-2671	233	4	learning	learning	NOUN
fnp-2671	233	5	/	/	SYM
fnp-2671	233	6	machine	machine	NOUN
fnp-2671	233	7	learning	learning	NOUN
fnp-2671	233	8	approaches	approach	NOUN
fnp-2671	233	9	may	may	AUX
fnp-2671	233	10	increasingly	increasingly	ADV
fnp-2671	233	11	be	be	AUX
fnp-2671	233	12	used	use	VERB
fnp-2671	233	13	for	for	ADP
fnp-2671	233	14	automated	automate	VERB
fnp-2671	233	15	,	,	PUNCT
fnp-2671	233	16	histology	histology	NOUN
fnp-2671	233	17	-	-	PUNCT
fnp-2671	233	18	based	base	VERB
fnp-2671	233	19	brain	brain	NOUN
fnp-2671	233	20	tumor	tumor	NOUN
fnp-2671	233	21	classification	classification	NOUN
fnp-2671	233	22	and/or	and/or	CCONJ
fnp-2671	233	23	for	for	ADP
fnp-2671	233	24	predicting	predict	VERB
fnp-2671	233	25	molecular	molecular	ADJ
fnp-2671	233	26	markers	marker	NOUN
fnp-2671	233	27	based	base	VERB
fnp-2671	233	28	on	on	ADP
fnp-2671	233	29	mri	mri	NOUN
fnp-2671	233	30	or	or	CCONJ
fnp-2671	233	31	other	other	ADJ
fnp-2671	233	32	neuro	neuro	NOUN
fnp-2671	233	33	-	-	PUNCT
fnp-2671	233	34	imaging	imaging	NOUN
fnp-2671	233	35	modalities	modality	NOUN
fnp-2671	233	36	[	[	X
fnp-2671	233	37	59	59	NUM
fnp-2671	233	38	,	,	PUNCT
fnp-2671	233	39	60	60	NUM
fnp-2671	233	40	]	]	PUNCT
fnp-2671	233	41	.	.	PUNCT
fnp-2671	234	1	such	such	ADJ
fnp-2671	234	2	developments	development	NOUN
fnp-2671	234	3	could	could	AUX
fnp-2671	234	4	have	have	VERB
fnp-2671	234	5	significant	significant	ADJ
fnp-2671	234	6	impact	impact	NOUN
fnp-2671	234	7	on	on	ADP
fnp-2671	234	8	the	the	DET
fnp-2671	234	9	‘	'	PUNCT
fnp-2671	234	10	core	core	NOUN
fnp-2671	234	11	business	business	NOUN
fnp-2671	234	12	’	'	PUNCT
fnp-2671	234	13	of	of	ADP
fnp-2671	234	14	the	the	DET
fnp-2671	234	15	(	(	PUNCT
fnp-2671	234	16	neuro)pathologist	neuro)pathologist	PROPN
fnp-2671	234	17	.	.	PUNCT
fnp-2671	235	1	however	however	ADV
fnp-2671	235	2	,	,	PUNCT
fnp-2671	235	3	to	to	PART
fnp-2671	235	4	quote	quote	VERB
fnp-2671	235	5	the	the	DET
fnp-2671	235	6	editor	editor	NOUN
fnp-2671	235	7	-	-	PUNCT
fnp-2671	235	8	in	in	ADP
fnp-2671	235	9	-	-	PUNCT
fnp-2671	235	10	chief	chief	NOUN
fnp-2671	235	11	of	of	ADP
fnp-2671	235	12	free	free	ADJ
fnp-2671	235	13	neuropathology	neuropathology	NOUN
fnp-2671	235	14	:	:	PUNCT
fnp-2671	235	15	‘	'	PUNCT
fnp-2671	235	16	as	as	ADV
fnp-2671	235	17	long	long	ADV
fnp-2671	235	18	as	as	SCONJ
fnp-2671	235	19	neuropathology	neuropathology	NOUN
fnp-2671	235	20	continues	continue	VERB
fnp-2671	235	21	to	to	PART
fnp-2671	235	22	be	be	AUX
fnp-2671	235	23	creative	creative	ADJ
fnp-2671	235	24	and	and	CCONJ
fnp-2671	235	25	innovative	innovative	ADJ
fnp-2671	235	26	at	at	ADP
fnp-2671	235	27	the	the	DET
fnp-2671	235	28	forefront	forefront	NOUN
fnp-2671	235	29	of	of	ADP
fnp-2671	235	30	classifying	classify	VERB
fnp-2671	235	31	and	and	CCONJ
fnp-2671	235	32	diagnosing	diagnose	VERB
fnp-2671	235	33	neurological	neurological	ADJ
fnp-2671	235	34	disorders	disorder	NOUN
fnp-2671	235	35	and	and	CCONJ
fnp-2671	235	36	revealing	reveal	VERB
fnp-2671	235	37	their	their	PRON
fnp-2671	235	38	molecular	molecular	ADJ
fnp-2671	235	39	pathogenesis	pathogenesis	NOUN
fnp-2671	235	40	…	…	PUNCT
fnp-2671	235	41	,	,	PUNCT
fnp-2671	235	42	its	its	PRON
fnp-2671	235	43	future	future	NOUN
fnp-2671	235	44	will	will	AUX
fnp-2671	235	45	be	be	AUX
fnp-2671	235	46	bright	bright	ADJ
fnp-2671	235	47	’	'	PUNCT
fnp-2671	235	48	[	[	X
fnp-2671	235	49	52	52	NUM
fnp-2671	235	50	]	]	PUNCT
fnp-2671	235	51	.	.	PUNCT
fnp-2671	236	1	references	reference	NOUN
fnp-2671	236	2	1	1	NUM
fnp-2671	236	3	.	.	X
fnp-2671	237	1	filipski	filipski	PROPN
fnp-2671	237	2	,	,	PUNCT
fnp-2671	237	3	k.	k.	PROPN
fnp-2671	237	4	,	,	PUNCT
fnp-2671	237	5	et	et	PROPN
fnp-2671	237	6	al	al	PROPN
fnp-2671	237	7	.	.	PROPN
fnp-2671	237	8	,	,	PUNCT
fnp-2671	237	9	lack	lack	NOUN
fnp-2671	237	10	of	of	ADP
fnp-2671	237	11	h3k27	h3k27	PROPN
fnp-2671	237	12	trimethylation	trimethylation	NOUN
fnp-2671	237	13	is	be	AUX
fnp-2671	237	14	associated	associate	VERB
fnp-2671	237	15	with	with	ADP
fnp-2671	237	16	1p/19q	1p/19q	PROPN
fnp-2671	237	17	codeletion	codeletion	NOUN
fnp-2671	237	18	in	in	ADP
fnp-2671	237	19	diffuse	diffuse	ADJ
fnp-2671	237	20	gliomas	glioma	NOUN
fnp-2671	237	21	.	.	PUNCT
fnp-2671	238	1	acta	acta	PROPN
fnp-2671	238	2	neuropathol	neuropathol	PROPN
fnp-2671	238	3	,	,	PUNCT
fnp-2671	238	4	2019	2019	NUM
fnp-2671	238	5	.	.	PUNCT
fnp-2671	239	1	138(2	138(2	NUM
fnp-2671	239	2	):	):	PUNCT
fnp-2671	239	3	p.	p.	NOUN
fnp-2671	239	4	331	331	NUM
fnp-2671	239	5	-	-	SYM
fnp-2671	239	6	334	334	NUM
fnp-2671	239	7	.	.	PUNCT
fnp-2671	240	1	2	2	X
fnp-2671	240	2	.	.	X
fnp-2671	240	3	sievers	siever	NOUN
fnp-2671	240	4	,	,	PUNCT
fnp-2671	240	5	p.	p.	PROPN
fnp-2671	240	6	,	,	PUNCT
fnp-2671	240	7	et	et	PROPN
fnp-2671	240	8	al	al	PROPN
fnp-2671	240	9	.	.	PROPN
fnp-2671	240	10	,	,	PUNCT
fnp-2671	240	11	rosette	rosette	NOUN
fnp-2671	240	12	-	-	PUNCT
fnp-2671	240	13	forming	form	VERB
fnp-2671	240	14	glioneuronal	glioneuronal	ADJ
fnp-2671	240	15	tumors	tumor	NOUN
fnp-2671	240	16	share	share	VERB
fnp-2671	240	17	a	a	DET
fnp-2671	240	18	distinct	distinct	ADJ
fnp-2671	240	19	dna	dna	NOUN
fnp-2671	240	20	methylation	methylation	NOUN
fnp-2671	240	21	profile	profile	NOUN
fnp-2671	240	22	and	and	CCONJ
fnp-2671	240	23	mutations	mutation	NOUN
fnp-2671	240	24	in	in	ADP
fnp-2671	240	25	fgfr1	fgfr1	PROPN
fnp-2671	240	26	,	,	PUNCT
fnp-2671	240	27	with	with	ADP
fnp-2671	240	28	recurrent	recurrent	ADJ
fnp-2671	240	29	co	co	NOUN
fnp-2671	240	30	-	-	NOUN
fnp-2671	240	31	mutation	mutation	NOUN
fnp-2671	240	32	of	of	ADP
fnp-2671	240	33	pik3ca	pik3ca	NOUN
fnp-2671	240	34	and	and	CCONJ
fnp-2671	240	35	nf1	nf1	NOUN
fnp-2671	240	36	.	.	PUNCT
fnp-2671	241	1	acta	acta	PROPN
fnp-2671	241	2	neuropathol	neuropathol	PROPN
fnp-2671	241	3	,	,	PUNCT
fnp-2671	241	4	2019	2019	NUM
fnp-2671	241	5	.	.	PUNCT
fnp-2671	242	1	138(3	138(3	NUM
fnp-2671	242	2	):	):	PUNCT
fnp-2671	242	3	p.	p.	NOUN
fnp-2671	242	4	497	497	NUM
fnp-2671	242	5	-	-	SYM
fnp-2671	242	6	504	504	NUM
fnp-2671	242	7	.	.	PUNCT
fnp-2671	243	1	3	3	X
fnp-2671	243	2	.	.	X
fnp-2671	244	1	hou	hou	NOUN
fnp-2671	244	2	,	,	PUNCT
fnp-2671	244	3	y.	y.	PROPN
fnp-2671	244	4	,	,	PUNCT
fnp-2671	244	5	et	et	PROPN
fnp-2671	244	6	al	al	PROPN
fnp-2671	244	7	.	.	PROPN
fnp-2671	244	8	,	,	PUNCT
fnp-2671	244	9	papillary	papillary	ADJ
fnp-2671	244	10	glioneuronal	glioneuronal	ADJ
fnp-2671	244	11	tumor	tumor	NOUN
fnp-2671	244	12	(	(	PUNCT
fnp-2671	244	13	pgnt	pgnt	PROPN
fnp-2671	244	14	)	)	PUNCT
fnp-2671	244	15	exhibits	exhibit	VERB
fnp-2671	244	16	a	a	DET
fnp-2671	244	17	characteristic	characteristic	ADJ
fnp-2671	244	18	methylation	methylation	NOUN
fnp-2671	244	19	profile	profile	NOUN
fnp-2671	244	20	and	and	CCONJ
fnp-2671	244	21	fusions	fusion	NOUN
fnp-2671	244	22	involving	involve	VERB
fnp-2671	244	23	prkca	prkca	PROPN
fnp-2671	244	24	.	.	PUNCT
fnp-2671	245	1	acta	acta	PROPN
fnp-2671	245	2	neuropathol	neuropathol	PROPN
fnp-2671	245	3	,	,	PUNCT
fnp-2671	245	4	2019	2019	NUM
fnp-2671	245	5	.	.	PUNCT
fnp-2671	246	1	137(5	137(5	NUM
fnp-2671	246	2	):	):	PUNCT
fnp-2671	246	3	p.	p.	NOUN
fnp-2671	246	4	837	837	NUM
fnp-2671	246	5	-	-	SYM
fnp-2671	246	6	846	846	NUM
fnp-2671	246	7	.	.	PUNCT
fnp-2671	246	8	4	4	NUM
fnp-2671	246	9	.	.	X
fnp-2671	246	10	sharma	sharma	PROPN
fnp-2671	246	11	,	,	PUNCT
fnp-2671	246	12	t.	t.	PROPN
fnp-2671	246	13	,	,	PUNCT
fnp-2671	246	14	et	et	PROPN
fnp-2671	246	15	al	al	PROPN
fnp-2671	246	16	.	.	PROPN
fnp-2671	246	17	,	,	PUNCT
fnp-2671	246	18	second	second	ADJ
fnp-2671	246	19	-	-	PUNCT
fnp-2671	246	20	generation	generation	NOUN
fnp-2671	246	21	molecular	molecular	ADJ
fnp-2671	246	22	subgrouping	subgrouping	NOUN
fnp-2671	246	23	of	of	ADP
fnp-2671	246	24	medulloblastoma	medulloblastoma	NOUN
fnp-2671	246	25	:	:	PUNCT
fnp-2671	246	26	an	an	DET
fnp-2671	246	27	international	international	ADJ
fnp-2671	246	28	meta	meta	NOUN
fnp-2671	246	29	-	-	PUNCT
fnp-2671	246	30	analysis	analysis	NOUN
fnp-2671	246	31	of	of	ADP
fnp-2671	246	32	group	group	NOUN
fnp-2671	246	33	3	3	NUM
fnp-2671	246	34	and	and	CCONJ
fnp-2671	246	35	group	group	NOUN
fnp-2671	246	36	4	4	NUM
fnp-2671	246	37	subtypes	subtype	NOUN
fnp-2671	246	38	.	.	PUNCT
fnp-2671	247	1	acta	acta	PROPN
fnp-2671	247	2	neuropathol	neuropathol	PROPN
fnp-2671	247	3	,	,	PUNCT
fnp-2671	247	4	2019	2019	NUM
fnp-2671	247	5	.	.	PUNCT
fnp-2671	248	1	138(2	138(2	NUM
fnp-2671	248	2	):	):	PUNCT
fnp-2671	249	1	p.	p.	NOUN
fnp-2671	249	2	309	309	NUM
fnp-2671	249	3	-	-	SYM
fnp-2671	249	4	326	326	NUM
fnp-2671	249	5	.	.	NOUN
fnp-2671	249	6	5	5	NUM
fnp-2671	249	7	.	.	X
fnp-2671	249	8	vladoiu	vladoiu	PROPN
fnp-2671	249	9	,	,	PUNCT
fnp-2671	249	10	m.c	m.c	PROPN
fnp-2671	249	11	.	.	PROPN
fnp-2671	249	12	,	,	PUNCT
fnp-2671	249	13	et	et	PROPN
fnp-2671	249	14	al	al	PROPN
fnp-2671	249	15	.	.	PROPN
fnp-2671	249	16	,	,	PUNCT
fnp-2671	249	17	childhood	childhood	PROPN
fnp-2671	249	18	cerebellar	cerebellar	PROPN
fnp-2671	249	19	tumours	tumours	PROPN
fnp-2671	249	20	mirror	mirror	NOUN
fnp-2671	249	21	conserved	conserve	VERB
fnp-2671	249	22	fetal	fetal	ADJ
fnp-2671	249	23	transcriptional	transcriptional	NOUN
fnp-2671	249	24	programs	program	NOUN
fnp-2671	249	25	.	.	PUNCT
fnp-2671	250	1	nature	nature	NOUN
fnp-2671	250	2	,	,	PUNCT
fnp-2671	250	3	2019	2019	NUM
fnp-2671	250	4	.	.	PUNCT
fnp-2671	251	1	572(7767	572(7767	NUM
fnp-2671	251	2	):	):	PUNCT
fnp-2671	252	1	p.	p.	NOUN
fnp-2671	252	2	67	67	NUM
fnp-2671	252	3	-	-	SYM
fnp-2671	252	4	73	73	NUM
fnp-2671	252	5	.	.	PUNCT
fnp-2671	253	1	6	6	NUM
fnp-2671	253	2	.	.	X
fnp-2671	253	3	hovestadt	hovestadt	NOUN
fnp-2671	253	4	,	,	PUNCT
fnp-2671	253	5	v.	v.	ADV
fnp-2671	253	6	,	,	PUNCT
fnp-2671	253	7	et	et	PROPN
fnp-2671	253	8	al	al	PROPN
fnp-2671	253	9	.	.	PROPN
fnp-2671	253	10	,	,	PUNCT
fnp-2671	253	11	resolving	resolve	VERB
fnp-2671	253	12	medulloblastoma	medulloblastoma	ADJ
fnp-2671	253	13	cellular	cellular	ADJ
fnp-2671	253	14	architecture	architecture	NOUN
fnp-2671	253	15	by	by	ADP
fnp-2671	253	16	single	single	ADJ
fnp-2671	253	17	-	-	PUNCT
fnp-2671	253	18	cell	cell	NOUN
fnp-2671	253	19	genomics	genomic	NOUN
fnp-2671	253	20	.	.	PUNCT
fnp-2671	254	1	nature	nature	NOUN
fnp-2671	254	2	,	,	PUNCT
fnp-2671	254	3	2019	2019	NUM
fnp-2671	254	4	.	.	PUNCT
fnp-2671	255	1	572(7767	572(7767	NUM
fnp-2671	255	2	):	):	PUNCT
fnp-2671	255	3	p.	p.	NOUN
fnp-2671	255	4	74	74	NUM
fnp-2671	255	5	-	-	SYM
fnp-2671	255	6	79	79	NUM
fnp-2671	255	7	.	.	PUNCT
fnp-2671	256	1	7	7	X
fnp-2671	256	2	.	.	X
fnp-2671	256	3	jessa	jessa	PROPN
fnp-2671	256	4	,	,	PUNCT
fnp-2671	256	5	s.	s.	PROPN
fnp-2671	256	6	,	,	PUNCT
fnp-2671	256	7	et	et	PROPN
fnp-2671	256	8	al	al	PROPN
fnp-2671	256	9	.	.	PROPN
fnp-2671	256	10	,	,	PUNCT
fnp-2671	256	11	stalled	stall	VERB
fnp-2671	256	12	developmental	developmental	ADJ
fnp-2671	256	13	programs	program	NOUN
fnp-2671	256	14	at	at	ADP
fnp-2671	256	15	the	the	DET
fnp-2671	256	16	root	root	NOUN
fnp-2671	256	17	of	of	ADP
fnp-2671	256	18	pediatric	pediatric	ADJ
fnp-2671	256	19	brain	brain	NOUN
fnp-2671	256	20	tumors	tumor	NOUN
fnp-2671	256	21	.	.	PUNCT
fnp-2671	257	1	nat	nat	PROPN
fnp-2671	257	2	genet	genet	PROPN
fnp-2671	257	3	,	,	PUNCT
fnp-2671	257	4	2019	2019	NUM
fnp-2671	257	5	.	.	PUNCT
fnp-2671	258	1	51(12	51(12	NUM
fnp-2671	258	2	):	):	PUNCT
fnp-2671	258	3	p.	p.	NOUN
fnp-2671	258	4	1702	1702	NUM
fnp-2671	258	5	-	-	SYM
fnp-2671	258	6	1713	1713	NUM
fnp-2671	258	7	.	.	PUNCT
fnp-2671	259	1	8	8	NUM
fnp-2671	259	2	.	.	X
fnp-2671	259	3	barthel	barthel	PROPN
fnp-2671	259	4	,	,	PUNCT
fnp-2671	259	5	f.p	f.p	PROPN
fnp-2671	259	6	.	.	PROPN
fnp-2671	259	7	,	,	PUNCT
fnp-2671	259	8	et	et	PROPN
fnp-2671	259	9	al	al	PROPN
fnp-2671	259	10	.	.	PROPN
fnp-2671	259	11	,	,	PUNCT
fnp-2671	259	12	longitudinal	longitudinal	ADJ
fnp-2671	259	13	molecular	molecular	ADJ
fnp-2671	259	14	trajectories	trajectory	NOUN
fnp-2671	259	15	of	of	ADP
fnp-2671	259	16	diffuse	diffuse	ADJ
fnp-2671	259	17	glioma	glioma	NOUN
fnp-2671	259	18	in	in	ADP
fnp-2671	259	19	adults	adult	NOUN
fnp-2671	259	20	.	.	PUNCT
fnp-2671	260	1	nature	nature	NOUN
fnp-2671	260	2	,	,	PUNCT
fnp-2671	260	3	2019	2019	NUM
fnp-2671	260	4	.	.	PUNCT
fnp-2671	261	1	576(7785	576(7785	NUM
fnp-2671	261	2	):	):	PUNCT
fnp-2671	261	3	p.	p.	NOUN
fnp-2671	261	4	112	112	NUM
fnp-2671	261	5	-	-	SYM
fnp-2671	261	6	120	120	NUM
fnp-2671	261	7	.	.	PUNCT
fnp-2671	262	1	9	9	NUM
fnp-2671	262	2	.	.	X
fnp-2671	262	3	wang	wang	PROPN
fnp-2671	262	4	,	,	PUNCT
fnp-2671	262	5	j.	j.	PROPN
fnp-2671	262	6	,	,	PUNCT
fnp-2671	262	7	et	et	PROPN
fnp-2671	262	8	al	al	PROPN
fnp-2671	262	9	.	.	PROPN
fnp-2671	262	10	,	,	PUNCT
fnp-2671	262	11	invasion	invasion	NOUN
fnp-2671	262	12	of	of	ADP
fnp-2671	262	13	white	white	ADJ
fnp-2671	262	14	matter	matter	NOUN
fnp-2671	262	15	tracts	tract	NOUN
fnp-2671	262	16	by	by	ADP
fnp-2671	262	17	glioma	glioma	NOUN
fnp-2671	262	18	stem	stem	NOUN
fnp-2671	262	19	cells	cell	NOUN
fnp-2671	262	20	is	be	AUX
fnp-2671	262	21	regulated	regulate	VERB
fnp-2671	262	22	by	by	ADP
fnp-2671	262	23	a	a	DET
fnp-2671	262	24	notch1	notch1	NOUN
fnp-2671	262	25	-	-	PUNCT
fnp-2671	262	26	sox2	sox2	ADJ
fnp-2671	262	27	positive	positive	ADJ
fnp-2671	262	28	-	-	PUNCT
fnp-2671	262	29	feedback	feedback	NOUN
fnp-2671	262	30	loop	loop	NOUN
fnp-2671	262	31	.	.	PUNCT
fnp-2671	263	1	nat	nat	PROPN
fnp-2671	263	2	neurosci	neurosci	PROPN
fnp-2671	263	3	,	,	PUNCT
fnp-2671	263	4	2019	2019	NUM
fnp-2671	263	5	.	.	PUNCT
fnp-2671	264	1	22(1	22(1	NUM
fnp-2671	264	2	):	):	PUNCT
fnp-2671	264	3	p.	p.	NOUN
fnp-2671	264	4	91	91	NUM
fnp-2671	264	5	-	-	SYM
fnp-2671	264	6	105	105	NUM
fnp-2671	264	7	.	.	PUNCT
fnp-2671	264	8	10	10	NUM
fnp-2671	264	9	.	.	PUNCT
fnp-2671	265	1	venkatesh	venkatesh	PROPN
fnp-2671	265	2	,	,	PUNCT
fnp-2671	265	3	h.s	h.s	PROPN
fnp-2671	265	4	.	.	PROPN
fnp-2671	265	5	,	,	PUNCT
fnp-2671	265	6	et	et	PROPN
fnp-2671	265	7	al	al	PROPN
fnp-2671	265	8	.	.	PROPN
fnp-2671	265	9	,	,	PUNCT
fnp-2671	265	10	electrical	electrical	ADJ
fnp-2671	265	11	and	and	CCONJ
fnp-2671	265	12	synaptic	synaptic	ADJ
fnp-2671	265	13	integration	integration	NOUN
fnp-2671	265	14	of	of	ADP
fnp-2671	265	15	glioma	glioma	NOUN
fnp-2671	265	16	into	into	ADP
fnp-2671	265	17	neural	neural	ADJ
fnp-2671	265	18	circuits	circuit	NOUN
fnp-2671	265	19	.	.	PUNCT
fnp-2671	266	1	nature	nature	NOUN
fnp-2671	266	2	,	,	PUNCT
fnp-2671	266	3	2019	2019	NUM
fnp-2671	266	4	.	.	PUNCT
fnp-2671	267	1	573(7775	573(7775	ADV
fnp-2671	267	2	):	):	PUNCT
fnp-2671	267	3	p.	p.	NOUN
fnp-2671	267	4	539	539	NUM
fnp-2671	267	5	-	-	SYM
fnp-2671	267	6	545	545	NUM
fnp-2671	267	7	.	.	PUNCT
fnp-2671	268	1	11	11	NUM
fnp-2671	268	2	.	.	PUNCT
fnp-2671	269	1	venkataramani	venkataramani	PROPN
fnp-2671	269	2	,	,	PUNCT
fnp-2671	269	3	v.	v.	ADV
fnp-2671	269	4	,	,	PUNCT
fnp-2671	269	5	et	et	PROPN
fnp-2671	269	6	al	al	PROPN
fnp-2671	269	7	.	.	PROPN
fnp-2671	269	8	,	,	PUNCT
fnp-2671	269	9	glutamatergic	glutamatergic	ADJ
fnp-2671	269	10	synaptic	synaptic	ADJ
fnp-2671	269	11	input	input	NOUN
fnp-2671	269	12	to	to	ADP
fnp-2671	269	13	glioma	glioma	NOUN
fnp-2671	269	14	cells	cell	NOUN
fnp-2671	269	15	drives	drive	VERB
fnp-2671	269	16	brain	brain	VERB
fnp-2671	269	17	tumour	tumour	NOUN
fnp-2671	269	18	progression	progression	NOUN
fnp-2671	269	19	.	.	PUNCT
fnp-2671	270	1	nature	nature	NOUN
fnp-2671	270	2	,	,	PUNCT
fnp-2671	270	3	2019	2019	NUM
fnp-2671	270	4	.	.	PUNCT
fnp-2671	271	1	573(7775	573(7775	NUM
fnp-2671	271	2	):	):	PUNCT
fnp-2671	271	3	p.	p.	NOUN
fnp-2671	271	4	532	532	NUM
fnp-2671	271	5	-	-	SYM
fnp-2671	271	6	538	538	NUM
fnp-2671	271	7	.	.	PUNCT
fnp-2671	272	1	12	12	NUM
fnp-2671	272	2	.	.	PUNCT
fnp-2671	273	1	zeng	zeng	PROPN
fnp-2671	273	2	,	,	PUNCT
fnp-2671	273	3	q.	q.	PROPN
fnp-2671	273	4	,	,	PUNCT
fnp-2671	273	5	et	et	PROPN
fnp-2671	273	6	al	al	PROPN
fnp-2671	273	7	.	.	PROPN
fnp-2671	273	8	,	,	PUNCT
fnp-2671	273	9	synaptic	synaptic	ADJ
fnp-2671	273	10	proximity	proximity	NOUN
fnp-2671	273	11	enables	enable	VERB
fnp-2671	273	12	nmdar	nmdar	ADV
fnp-2671	273	13	signalling	signal	VERB
fnp-2671	273	14	to	to	PART
fnp-2671	273	15	promote	promote	VERB
fnp-2671	273	16	brain	brain	NOUN
fnp-2671	273	17	metastasis	metastasis	NOUN
fnp-2671	273	18	.	.	PUNCT
fnp-2671	274	1	nature	nature	NOUN
fnp-2671	274	2	,	,	PUNCT
fnp-2671	274	3	2019	2019	NUM
fnp-2671	274	4	.	.	PUNCT
fnp-2671	275	1	573(7775	573(7775	NUM
fnp-2671	275	2	):	):	PUNCT
fnp-2671	275	3	p.	p.	NOUN
fnp-2671	275	4	526	526	NUM
fnp-2671	275	5	-	-	SYM
fnp-2671	275	6	531	531	NUM
fnp-2671	275	7	.	.	PUNCT
fnp-2671	276	1	13	13	NUM
fnp-2671	276	2	.	.	X
fnp-2671	277	1	dirkse	dirkse	PROPN
fnp-2671	277	2	,	,	PUNCT
fnp-2671	277	3	a.	a.	NOUN
fnp-2671	277	4	,	,	PUNCT
fnp-2671	277	5	et	et	PROPN
fnp-2671	277	6	al	al	PROPN
fnp-2671	277	7	.	.	PROPN
fnp-2671	277	8	,	,	PUNCT
fnp-2671	277	9	stem	stem	VERB
fnp-2671	277	10	cell	cell	NOUN
fnp-2671	277	11	-	-	PUNCT
fnp-2671	277	12	associated	associate	VERB
fnp-2671	277	13	heterogeneity	heterogeneity	NOUN
fnp-2671	277	14	in	in	ADP
fnp-2671	277	15	glioblastoma	glioblastoma	NOUN
fnp-2671	277	16	results	result	NOUN
fnp-2671	277	17	from	from	ADP
fnp-2671	277	18	intrinsic	intrinsic	ADJ
fnp-2671	277	19	tumor	tumor	NOUN
fnp-2671	277	20	plasticity	plasticity	NOUN
fnp-2671	277	21	shaped	shape	VERB
fnp-2671	277	22	by	by	ADP
fnp-2671	277	23	the	the	DET
fnp-2671	277	24	microenvironment	microenvironment	NOUN
fnp-2671	277	25	.	.	PUNCT
fnp-2671	278	1	nat	nat	PROPN
fnp-2671	278	2	commun	commun	PROPN
fnp-2671	278	3	,	,	PUNCT
fnp-2671	278	4	2019	2019	NUM
fnp-2671	278	5	.	.	PUNCT
fnp-2671	279	1	10(1	10(1	NUM
fnp-2671	279	2	):	):	PUNCT
fnp-2671	279	3	p.	p.	NOUN
fnp-2671	279	4	1787	1787	NUM
fnp-2671	279	5	.	.	PUNCT
fnp-2671	280	1	14	14	NUM
fnp-2671	280	2	.	.	PUNCT
fnp-2671	281	1	keskin	keskin	PROPN
fnp-2671	281	2	,	,	PUNCT
fnp-2671	281	3	d.b	d.b	PROPN
fnp-2671	281	4	.	.	PROPN
fnp-2671	281	5	,	,	PUNCT
fnp-2671	281	6	et	et	PROPN
fnp-2671	281	7	al	al	PROPN
fnp-2671	281	8	.	.	PROPN
fnp-2671	281	9	,	,	PUNCT
fnp-2671	281	10	neoantigen	neoantigen	PROPN
fnp-2671	281	11	vaccine	vaccine	NOUN
fnp-2671	281	12	generates	generate	VERB
fnp-2671	281	13	intratumoral	intratumoral	ADJ
fnp-2671	281	14	t	t	PROPN
fnp-2671	281	15	cell	cell	NOUN
fnp-2671	281	16	responses	response	NOUN
fnp-2671	281	17	in	in	ADP
fnp-2671	281	18	phase	phase	NOUN
fnp-2671	281	19	ib	ib	NOUN
fnp-2671	281	20	glioblastoma	glioblastoma	NOUN
fnp-2671	281	21	trial	trial	NOUN
fnp-2671	281	22	.	.	PUNCT
fnp-2671	282	1	nature	nature	NOUN
fnp-2671	282	2	,	,	PUNCT
fnp-2671	282	3	2019	2019	NUM
fnp-2671	282	4	.	.	PUNCT
fnp-2671	283	1	565(7738	565(7738	NOUN
fnp-2671	283	2	):	):	PUNCT
fnp-2671	283	3	p.	p.	NOUN
fnp-2671	283	4	234	234	NUM
fnp-2671	283	5	-	-	SYM
fnp-2671	283	6	239	239	NUM
fnp-2671	283	7	.	.	PUNCT
fnp-2671	283	8	15	15	NUM
fnp-2671	283	9	.	.	PUNCT
fnp-2671	284	1	hilf	hilf	PROPN
fnp-2671	284	2	,	,	PUNCT
fnp-2671	284	3	n.	n.	PROPN
fnp-2671	284	4	,	,	PUNCT
fnp-2671	284	5	et	et	PROPN
fnp-2671	284	6	al	al	PROPN
fnp-2671	284	7	.	.	PROPN
fnp-2671	284	8	,	,	PUNCT
fnp-2671	284	9	actively	actively	ADV
fnp-2671	284	10	personalized	personalize	VERB
fnp-2671	284	11	vaccination	vaccination	NOUN
fnp-2671	284	12	trial	trial	NOUN
fnp-2671	284	13	for	for	ADP
fnp-2671	284	14	newly	newly	ADV
fnp-2671	284	15	diagnosed	diagnose	VERB
fnp-2671	284	16	glioblastoma	glioblastoma	NOUN
fnp-2671	284	17	.	.	PUNCT
fnp-2671	285	1	nature	nature	NOUN
fnp-2671	285	2	,	,	PUNCT
fnp-2671	285	3	2019	2019	NUM
fnp-2671	285	4	.	.	PUNCT
fnp-2671	286	1	565(7738	565(7738	NOUN
fnp-2671	286	2	):	):	PUNCT
fnp-2671	286	3	p.	p.	NOUN
fnp-2671	286	4	240	240	NUM
fnp-2671	286	5	-	-	SYM
fnp-2671	286	6	245	245	NUM
fnp-2671	286	7	.	.	PUNCT
fnp-2671	287	1	16	16	NUM
fnp-2671	287	2	.	.	PUNCT
fnp-2671	288	1	miller	miller	PROPN
fnp-2671	288	2	,	,	PUNCT
fnp-2671	288	3	a.m.	a.m.	ADV
fnp-2671	288	4	,	,	PUNCT
fnp-2671	288	5	et	et	PROPN
fnp-2671	288	6	al	al	PROPN
fnp-2671	288	7	.	.	PROPN
fnp-2671	288	8	,	,	PUNCT
fnp-2671	288	9	tracking	track	VERB
fnp-2671	288	10	tumour	tumour	ADJ
fnp-2671	288	11	evolution	evolution	NOUN
fnp-2671	288	12	in	in	ADP
fnp-2671	288	13	glioma	glioma	NOUN
fnp-2671	288	14	through	through	ADP
fnp-2671	288	15	liquid	liquid	ADJ
fnp-2671	288	16	biopsies	biopsy	NOUN
fnp-2671	288	17	of	of	ADP
fnp-2671	288	18	cerebrospinal	cerebrospinal	ADJ
fnp-2671	288	19	fluid	fluid	NOUN
fnp-2671	288	20	.	.	PUNCT
fnp-2671	289	1	nature	nature	NOUN
fnp-2671	289	2	,	,	PUNCT
fnp-2671	289	3	2019	2019	NUM
fnp-2671	289	4	.	.	PUNCT
fnp-2671	290	1	565(7741	565(7741	NUM
fnp-2671	290	2	):	):	PUNCT
fnp-2671	290	3	p.	p.	NOUN
fnp-2671	290	4	654	654	NUM
fnp-2671	290	5	-	-	SYM
fnp-2671	290	6	658	658	NUM
fnp-2671	290	7	.	.	PUNCT
fnp-2671	291	1	17	17	NUM
fnp-2671	291	2	.	.	PUNCT
fnp-2671	292	1	pan	pan	PROPN
fnp-2671	292	2	,	,	PUNCT
fnp-2671	292	3	c.	c.	PROPN
fnp-2671	292	4	,	,	PUNCT
fnp-2671	292	5	et	et	PROPN
fnp-2671	292	6	al	al	PROPN
fnp-2671	292	7	.	.	PROPN
fnp-2671	292	8	,	,	PUNCT
fnp-2671	292	9	molecular	molecular	ADJ
fnp-2671	292	10	profiling	profiling	NOUN
fnp-2671	292	11	of	of	ADP
fnp-2671	292	12	tumors	tumor	NOUN
fnp-2671	292	13	of	of	ADP
fnp-2671	292	14	the	the	DET
fnp-2671	292	15	brainstem	brainstem	NOUN
fnp-2671	292	16	by	by	ADP
fnp-2671	292	17	sequencing	sequence	VERB
fnp-2671	292	18	of	of	ADP
fnp-2671	292	19	csf	csf	ADJ
fnp-2671	292	20	-	-	ADJ
fnp-2671	292	21	derived	derived	ADJ
fnp-2671	292	22	circulating	circulate	VERB
fnp-2671	292	23	tumor	tumor	NOUN
fnp-2671	292	24	dna	dna	PROPN
fnp-2671	292	25	.	.	PUNCT
fnp-2671	293	1	acta	acta	PROPN
fnp-2671	293	2	neuropathol	neuropathol	PROPN
fnp-2671	293	3	,	,	PUNCT
fnp-2671	293	4	2019	2019	NUM
fnp-2671	293	5	.	.	PUNCT
fnp-2671	294	1	137(2	137(2	NUM
fnp-2671	294	2	):	):	PUNCT
fnp-2671	294	3	p.	p.	NOUN
fnp-2671	294	4	297	297	NUM
fnp-2671	294	5	-	-	SYM
fnp-2671	294	6	306	306	NUM
fnp-2671	294	7	.	.	PUNCT
fnp-2671	295	1	18	18	NUM
fnp-2671	295	2	.	.	NUM
fnp-2671	296	1	paramasivam	paramasivam	PROPN
fnp-2671	296	2	,	,	PUNCT
fnp-2671	296	3	n.	n.	PROPN
fnp-2671	296	4	,	,	PUNCT
fnp-2671	296	5	et	et	PROPN
fnp-2671	296	6	al	al	PROPN
fnp-2671	296	7	.	.	PROPN
fnp-2671	296	8	,	,	PUNCT
fnp-2671	296	9	mutational	mutational	ADJ
fnp-2671	296	10	patterns	pattern	NOUN
fnp-2671	296	11	and	and	CCONJ
fnp-2671	296	12	regulatory	regulatory	ADJ
fnp-2671	296	13	networks	network	NOUN
fnp-2671	296	14	in	in	ADP
fnp-2671	296	15	epigenetic	epigenetic	ADJ
fnp-2671	296	16	subgroups	subgroup	NOUN
fnp-2671	296	17	of	of	ADP
fnp-2671	296	18	meningioma	meningioma	NOUN
fnp-2671	296	19	.	.	PUNCT
fnp-2671	297	1	acta	acta	PROPN
fnp-2671	297	2	neuropathol	neuropathol	PROPN
fnp-2671	297	3	,	,	PUNCT
fnp-2671	297	4	2019	2019	NUM
fnp-2671	297	5	.	.	PUNCT
fnp-2671	298	1	138(2	138(2	NUM
fnp-2671	298	2	):	):	PUNCT
fnp-2671	298	3	p.	p.	NOUN
fnp-2671	298	4	295	295	NUM
fnp-2671	298	5	-	-	SYM
fnp-2671	298	6	308	308	NUM
fnp-2671	298	7	.	.	NOUN
fnp-2671	298	8	19	19	NUM
fnp-2671	298	9	.	.	X
fnp-2671	298	10	wesseling	wesseling	NOUN
fnp-2671	298	11	,	,	PUNCT
fnp-2671	298	12	p.	p.	NOUN
fnp-2671	298	13	,	,	PUNCT
fnp-2671	298	14	m.	m.	NOUN
fnp-2671	298	15	van	van	PROPN
fnp-2671	298	16	den	den	PROPN
fnp-2671	298	17	bent	bent	ADJ
fnp-2671	298	18	,	,	PUNCT
fnp-2671	298	19	and	and	CCONJ
fnp-2671	298	20	a.	a.	PROPN
fnp-2671	298	21	perry	perry	PROPN
fnp-2671	298	22	,	,	PUNCT
fnp-2671	298	23	oligodendroglioma	oligodendroglioma	VERB
fnp-2671	298	24	:	:	PUNCT
fnp-2671	298	25	pathology	pathology	NOUN
fnp-2671	298	26	,	,	PUNCT
fnp-2671	298	27	molecular	molecular	ADJ
fnp-2671	298	28	mechanisms	mechanism	NOUN
fnp-2671	298	29	and	and	CCONJ
fnp-2671	298	30	markers	marker	NOUN
fnp-2671	298	31	.	.	PUNCT
fnp-2671	299	1	acta	acta	PROPN
fnp-2671	299	2	neuropathol	neuropathol	PROPN
fnp-2671	299	3	,	,	PUNCT
fnp-2671	299	4	2015	2015	NUM
fnp-2671	299	5	.	.	PUNCT
fnp-2671	300	1	129(6	129(6	NUM
fnp-2671	300	2	):	):	PUNCT
fnp-2671	300	3	p.	p.	NOUN
fnp-2671	300	4	809	809	NUM
fnp-2671	300	5	-	-	SYM
fnp-2671	300	6	27	27	NUM
fnp-2671	300	7	.	.	PUNCT
fnp-2671	301	1	20	20	NUM
fnp-2671	301	2	.	.	PUNCT
fnp-2671	302	1	schaefer	schaefer	PROPN
fnp-2671	302	2	,	,	PUNCT
fnp-2671	302	3	i.m	i.m	PROPN
fnp-2671	302	4	.	.	PROPN
fnp-2671	302	5	,	,	PUNCT
fnp-2671	302	6	a.	a.	NOUN
fnp-2671	302	7	minkovsky	minkovsky	PROPN
fnp-2671	302	8	,	,	PUNCT
fnp-2671	302	9	and	and	CCONJ
fnp-2671	302	10	j.l	j.l	PROPN
fnp-2671	302	11	.	.	PROPN
fnp-2671	302	12	hornick	hornick	PROPN
fnp-2671	302	13	,	,	PUNCT
fnp-2671	302	14	h3k27me3	h3k27me3	PROPN
fnp-2671	302	15	immunohistochemistry	immunohistochemistry	PROPN
fnp-2671	302	16	highlights	highlight	VERB
fnp-2671	302	17	the	the	DET
fnp-2671	302	18	inactivated	inactivated	ADJ
fnp-2671	302	19	x	x	PUNCT
fnp-2671	302	20	chromosome	chromosome	NOUN
fnp-2671	302	21	(	(	PUNCT
fnp-2671	302	22	xi	xi	ADJ
fnp-2671	302	23	)	)	PUNCT
fnp-2671	302	24	and	and	CCONJ
fnp-2671	302	25	predicts	predict	VERB
fnp-2671	302	26	sex	sex	NOUN
fnp-2671	302	27	in	in	ADP
fnp-2671	302	28	non	non	ADJ
fnp-2671	302	29	-	-	ADJ
fnp-2671	302	30	neoplastic	neoplastic	ADJ
fnp-2671	302	31	tissues	tissue	NOUN
fnp-2671	302	32	.	.	PUNCT
fnp-2671	303	1	histopathology	histopathology	NOUN
fnp-2671	303	2	,	,	PUNCT
fnp-2671	303	3	2016	2016	NUM
fnp-2671	303	4	.	.	PUNCT
fnp-2671	304	1	69(4	69(4	NUM
fnp-2671	304	2	):	):	PUNCT
fnp-2671	305	1	p.	p.	NOUN
fnp-2671	305	2	702	702	NUM
fnp-2671	305	3	-	-	SYM
fnp-2671	305	4	4	4	NUM
fnp-2671	305	5	.	.	NUM
fnp-2671	305	6	21	21	NUM
fnp-2671	305	7	.	.	PUNCT
fnp-2671	306	1	panwalkar	panwalkar	NOUN
fnp-2671	306	2	,	,	PUNCT
fnp-2671	306	3	p.	p.	PROPN
fnp-2671	306	4	,	,	PUNCT
fnp-2671	306	5	et	et	PROPN
fnp-2671	306	6	al	al	PROPN
fnp-2671	306	7	.	.	PROPN
fnp-2671	306	8	,	,	PUNCT
fnp-2671	306	9	immunohistochemical	immunohistochemical	ADJ
fnp-2671	306	10	analysis	analysis	NOUN
fnp-2671	306	11	of	of	ADP
fnp-2671	306	12	h3k27me3	h3k27me3	PROPN
fnp-2671	306	13	demonstrates	demonstrate	VERB
fnp-2671	306	14	global	global	ADJ
fnp-2671	306	15	reduction	reduction	NOUN
fnp-2671	306	16	in	in	ADP
fnp-2671	306	17	group	group	NOUN
fnp-2671	306	18	-	-	PUNCT
fnp-2671	306	19	a	a	DET
fnp-2671	306	20	childhood	childhood	ADJ
fnp-2671	306	21	posterior	posterior	ADJ
fnp-2671	306	22	fossa	fossa	NOUN
fnp-2671	306	23	ependymoma	ependymoma	NOUN
fnp-2671	306	24	and	and	CCONJ
fnp-2671	306	25	is	be	AUX
fnp-2671	306	26	a	a	DET
fnp-2671	306	27	powerful	powerful	ADJ
fnp-2671	306	28	predictor	predictor	NOUN
fnp-2671	306	29	of	of	ADP
fnp-2671	306	30	outcome	outcome	NOUN
fnp-2671	306	31	.	.	PUNCT
fnp-2671	307	1	acta	acta	PROPN
fnp-2671	307	2	neuropathol	neuropathol	PROPN
fnp-2671	307	3	,	,	PUNCT
fnp-2671	307	4	2017	2017	NUM
fnp-2671	307	5	.	.	PUNCT
fnp-2671	308	1	134(5	134(5	NUM
fnp-2671	308	2	):	):	PUNCT
fnp-2671	309	1	p.	p.	NOUN
fnp-2671	309	2	705	705	NUM
fnp-2671	309	3	-	-	SYM
fnp-2671	309	4	714	714	NUM
fnp-2671	309	5	.	.	PUNCT
fnp-2671	309	6	22	22	NUM
fnp-2671	309	7	.	.	PUNCT
fnp-2671	310	1	cleven	cleven	VERB
fnp-2671	310	2	,	,	PUNCT
fnp-2671	310	3	a.h	a.h	PROPN
fnp-2671	310	4	.	.	PROPN
fnp-2671	310	5	,	,	PUNCT
fnp-2671	310	6	et	et	PROPN
fnp-2671	310	7	al	al	PROPN
fnp-2671	310	8	.	.	PROPN
fnp-2671	310	9	,	,	PUNCT
fnp-2671	310	10	loss	loss	NOUN
fnp-2671	310	11	of	of	ADP
fnp-2671	310	12	h3k27	h3k27	X
fnp-2671	310	13	tri	tri	ADJ
fnp-2671	310	14	-	-	NOUN
fnp-2671	310	15	methylation	methylation	NOUN
fnp-2671	310	16	is	be	AUX
fnp-2671	310	17	a	a	DET
fnp-2671	310	18	diagnostic	diagnostic	ADJ
fnp-2671	310	19	marker	marker	NOUN
fnp-2671	310	20	for	for	ADP
fnp-2671	310	21	malignant	malignant	ADJ
fnp-2671	310	22	peripheral	peripheral	ADJ
fnp-2671	310	23	nerve	nerve	NOUN
fnp-2671	310	24	sheath	sheath	NOUN
fnp-2671	310	25	tumors	tumor	NOUN
fnp-2671	310	26	and	and	CCONJ
fnp-2671	310	27	an	an	DET
fnp-2671	310	28	indicator	indicator	NOUN
fnp-2671	310	29	for	for	ADP
fnp-2671	310	30	an	an	DET
fnp-2671	310	31	inferior	inferior	ADJ
fnp-2671	310	32	survival	survival	NOUN
fnp-2671	310	33	.	.	PUNCT
fnp-2671	311	1	mod	mod	PROPN
fnp-2671	311	2	pathol	pathol	PROPN
fnp-2671	311	3	,	,	PUNCT
fnp-2671	311	4	2016	2016	NUM
fnp-2671	311	5	.	.	PUNCT
fnp-2671	312	1	29(6	29(6	NUM
fnp-2671	312	2	):	):	PUNCT
fnp-2671	312	3	p.	p.	NOUN
fnp-2671	312	4	582	582	NUM
fnp-2671	312	5	-	-	SYM
fnp-2671	312	6	90	90	NUM
fnp-2671	312	7	.	.	PUNCT
fnp-2671	312	8	23	23	NUM
fnp-2671	312	9	.	.	PUNCT
fnp-2671	313	1	katz	katz	PROPN
fnp-2671	313	2	,	,	PUNCT
fnp-2671	313	3	l.m	l.m	PROPN
fnp-2671	313	4	.	.	PROPN
fnp-2671	313	5	,	,	PUNCT
fnp-2671	313	6	et	et	PROPN
fnp-2671	313	7	al	al	PROPN
fnp-2671	313	8	.	.	PROPN
fnp-2671	313	9	,	,	PUNCT
fnp-2671	313	10	loss	loss	NOUN
fnp-2671	313	11	of	of	ADP
fnp-2671	313	12	histone	histone	NOUN
fnp-2671	313	13	h3k27me3	h3k27me3	PROPN
fnp-2671	313	14	identifies	identify	VERB
fnp-2671	313	15	a	a	DET
fnp-2671	313	16	subset	subset	NOUN
fnp-2671	313	17	of	of	ADP
fnp-2671	313	18	meningiomas	meningioma	NOUN
fnp-2671	313	19	with	with	ADP
fnp-2671	313	20	increased	increase	VERB
fnp-2671	313	21	risk	risk	NOUN
fnp-2671	313	22	of	of	ADP
fnp-2671	313	23	recurrence	recurrence	NOUN
fnp-2671	313	24	.	.	PUNCT
fnp-2671	314	1	acta	acta	PROPN
fnp-2671	314	2	neuropathol	neuropathol	PROPN
fnp-2671	314	3	,	,	PUNCT
fnp-2671	314	4	2018	2018	NUM
fnp-2671	314	5	.	.	PUNCT
fnp-2671	315	1	135(6	135(6	NUM
fnp-2671	315	2	):	):	PUNCT
fnp-2671	316	1	p.	p.	NOUN
fnp-2671	316	2	955	955	NUM
fnp-2671	316	3	-	-	SYM
fnp-2671	316	4	963	963	NUM
fnp-2671	316	5	.	.	NUM
fnp-2671	316	6	24	24	NUM
fnp-2671	316	7	.	.	X
fnp-2671	316	8	capper	capper	PROPN
fnp-2671	316	9	,	,	PUNCT
fnp-2671	316	10	d.	d.	PROPN
fnp-2671	316	11	,	,	PUNCT
fnp-2671	316	12	et	et	PROPN
fnp-2671	316	13	al	al	PROPN
fnp-2671	316	14	.	.	PROPN
fnp-2671	316	15	,	,	PUNCT
fnp-2671	316	16	dna	dna	PROPN
fnp-2671	316	17	methylation	methylation	NOUN
fnp-2671	316	18	-	-	PUNCT
fnp-2671	316	19	based	base	VERB
fnp-2671	316	20	classification	classification	NOUN
fnp-2671	316	21	of	of	ADP
fnp-2671	316	22	central	central	ADJ
fnp-2671	316	23	nervous	nervous	ADJ
fnp-2671	316	24	system	system	NOUN
fnp-2671	316	25	tumours	tumour	VERB
fnp-2671	316	26	.	.	PUNCT
fnp-2671	317	1	nature	nature	NOUN
fnp-2671	317	2	,	,	PUNCT
fnp-2671	317	3	2018	2018	NUM
fnp-2671	317	4	.	.	PUNCT
fnp-2671	318	1	555(7697	555(7697	NUM
fnp-2671	318	2	):	):	PUNCT
fnp-2671	318	3	p.	p.	NOUN
fnp-2671	318	4	469	469	NUM
fnp-2671	318	5	-	-	PROPN
fnp-2671	318	6	474	474	NUM
fnp-2671	318	7	.	.	PUNCT
fnp-2671	319	1	25	25	NUM
fnp-2671	319	2	.	.	X
fnp-2671	319	3	capper	capper	PROPN
fnp-2671	319	4	,	,	PUNCT
fnp-2671	319	5	d.	d.	PROPN
fnp-2671	319	6	,	,	PUNCT
fnp-2671	319	7	et	et	PROPN
fnp-2671	319	8	al	al	PROPN
fnp-2671	319	9	.	.	PROPN
fnp-2671	319	10	,	,	PUNCT
fnp-2671	319	11	practical	practical	ADJ
fnp-2671	319	12	implementation	implementation	NOUN
fnp-2671	319	13	of	of	ADP
fnp-2671	319	14	dna	dna	PROPN
fnp-2671	319	15	methylation	methylation	NOUN
fnp-2671	319	16	and	and	CCONJ
fnp-2671	319	17	copy	copy	NOUN
fnp-2671	319	18	-	-	PUNCT
fnp-2671	319	19	number	number	NOUN
fnp-2671	319	20	-	-	PUNCT
fnp-2671	319	21	based	base	VERB
fnp-2671	319	22	cns	cns	NOUN
fnp-2671	319	23	tumor	tumor	NOUN
fnp-2671	319	24	diagnostics	diagnostic	NOUN
fnp-2671	319	25	:	:	PUNCT
fnp-2671	319	26	the	the	DET
fnp-2671	319	27	heidelberg	heidelberg	NOUN
fnp-2671	319	28	experience	experience	NOUN
fnp-2671	319	29	.	.	PUNCT
fnp-2671	320	1	acta	acta	PROPN
fnp-2671	320	2	neuropathol	neuropathol	PROPN
fnp-2671	320	3	,	,	PUNCT
fnp-2671	320	4	2018	2018	NUM
fnp-2671	320	5	.	.	PUNCT
fnp-2671	321	1	136(2	136(2	NUM
fnp-2671	321	2	):	):	PUNCT
fnp-2671	322	1	p.	p.	NOUN
fnp-2671	322	2	181	181	NUM
fnp-2671	322	3	-	-	SYM
fnp-2671	322	4	210	210	NUM
fnp-2671	322	5	.	.	PUNCT
fnp-2671	323	1	26	26	NUM
fnp-2671	323	2	.	.	PUNCT
fnp-2671	324	1	jaunmuktane	jaunmuktane	NOUN
fnp-2671	324	2	,	,	PUNCT
fnp-2671	324	3	z.	z.	PROPN
fnp-2671	324	4	,	,	PUNCT
fnp-2671	324	5	et	et	PROPN
fnp-2671	324	6	al	al	PROPN
fnp-2671	324	7	.	.	PROPN
fnp-2671	324	8	,	,	PUNCT
fnp-2671	324	9	methylation	methylation	NOUN
fnp-2671	324	10	array	array	VERB
fnp-2671	324	11	profiling	profiling	NOUN
fnp-2671	324	12	of	of	ADP
fnp-2671	324	13	adult	adult	NOUN
fnp-2671	324	14	brain	brain	NOUN
fnp-2671	324	15	tumours	tumour	NOUN
fnp-2671	324	16	:	:	PUNCT
fnp-2671	324	17	diagnostic	diagnostic	ADJ
fnp-2671	324	18	outcomes	outcome	NOUN
fnp-2671	324	19	in	in	ADP
fnp-2671	324	20	a	a	DET
fnp-2671	324	21	large	large	ADJ
fnp-2671	324	22	,	,	PUNCT
fnp-2671	324	23	single	single	ADJ
fnp-2671	324	24	centre	centre	NOUN
fnp-2671	324	25	.	.	PUNCT
fnp-2671	325	1	acta	acta	PROPN
fnp-2671	325	2	neuropathol	neuropathol	PROPN
fnp-2671	325	3	commun	commun	PROPN
fnp-2671	325	4	,	,	PUNCT
fnp-2671	325	5	2019	2019	NUM
fnp-2671	325	6	.	.	PUNCT
fnp-2671	326	1	7(1	7(1	NUM
fnp-2671	326	2	):	):	PUNCT
fnp-2671	326	3	p.	p.	NOUN
fnp-2671	326	4	24	24	NUM
fnp-2671	326	5	.	.	PUNCT
fnp-2671	327	1	27	27	NUM
fnp-2671	327	2	.	.	PUNCT
fnp-2671	328	1	pickles	pickle	NOUN
fnp-2671	328	2	,	,	PUNCT
fnp-2671	328	3	j.c	j.c	PROPN
fnp-2671	328	4	.	.	PROPN
fnp-2671	328	5	,	,	PUNCT
fnp-2671	328	6	et	et	PROPN
fnp-2671	328	7	al	al	PROPN
fnp-2671	328	8	.	.	PROPN
fnp-2671	328	9	,	,	PUNCT
fnp-2671	328	10	dna	dna	PROPN
fnp-2671	328	11	methylation	methylation	NOUN
fnp-2671	328	12	-	-	PUNCT
fnp-2671	328	13	based	base	VERB
fnp-2671	328	14	profiling	profiling	NOUN
fnp-2671	328	15	for	for	ADP
fnp-2671	328	16	paediatric	paediatric	ADJ
fnp-2671	328	17	cns	cns	NOUN
fnp-2671	328	18	tumour	tumour	NOUN
fnp-2671	328	19	diagnosis	diagnosis	NOUN
fnp-2671	328	20	and	and	CCONJ
fnp-2671	328	21	treatment	treatment	NOUN
fnp-2671	328	22	:	:	PUNCT
fnp-2671	328	23	a	a	DET
fnp-2671	328	24	population	population	NOUN
fnp-2671	328	25	-	-	PUNCT
fnp-2671	328	26	based	base	VERB
fnp-2671	328	27	study	study	NOUN
fnp-2671	328	28	.	.	PUNCT
fnp-2671	329	1	lancet	lancet	PROPN
fnp-2671	329	2	child	child	PROPN
fnp-2671	329	3	adolesc	adolesc	PROPN
fnp-2671	329	4	health	health	NOUN
fnp-2671	329	5	,	,	PUNCT
fnp-2671	329	6	2020	2020	NUM
fnp-2671	329	7	.	.	PUNCT
fnp-2671	330	1	4(2	4(2	NUM
fnp-2671	330	2	):	):	PUNCT
fnp-2671	331	1	p.	p.	NOUN
fnp-2671	331	2	121	121	NUM
fnp-2671	331	3	-	-	SYM
fnp-2671	331	4	130	130	NUM
fnp-2671	331	5	.	.	PUNCT
fnp-2671	331	6	28	28	NUM
fnp-2671	331	7	.	.	PUNCT
fnp-2671	332	1	perez	perez	PROPN
fnp-2671	332	2	,	,	PUNCT
fnp-2671	332	3	e.	e.	PROPN
fnp-2671	332	4	and	and	CCONJ
fnp-2671	332	5	d.	d.	PROPN
fnp-2671	332	6	capper	capper	PROPN
fnp-2671	332	7	,	,	PUNCT
fnp-2671	332	8	dna	dna	NOUN
fnp-2671	332	9	-	-	PUNCT
fnp-2671	332	10	methylation	methylation	NOUN
fnp-2671	332	11	-	-	PUNCT
fnp-2671	332	12	based	base	VERB
fnp-2671	332	13	classification	classification	NOUN
fnp-2671	332	14	of	of	ADP
fnp-2671	332	15	paediatric	paediatric	ADJ
fnp-2671	332	16	brain	brain	NOUN
fnp-2671	332	17	tumours	tumours	X
fnp-2671	332	18	.	.	PUNCT
fnp-2671	333	1	neuropathol	neuropathol	PROPN
fnp-2671	333	2	appl	appl	PROPN
fnp-2671	333	3	neurobiol	neurobiol	PROPN
fnp-2671	333	4	,	,	PUNCT
fnp-2671	333	5	2020	2020	NUM
fnp-2671	333	6	.	.	PUNCT
fnp-2671	334	1	29	29	NUM
fnp-2671	334	2	.	.	PUNCT
fnp-2671	335	1	priesterbach	priesterbach	NOUN
fnp-2671	335	2	-	-	PUNCT
fnp-2671	335	3	ackley	ackley	PROPN
fnp-2671	335	4	,	,	PUNCT
fnp-2671	335	5	l.p	l.p	PROPN
fnp-2671	335	6	.	.	PROPN
fnp-2671	335	7	,	,	PUNCT
fnp-2671	335	8	et	et	PROPN
fnp-2671	335	9	al	al	PROPN
fnp-2671	335	10	.	.	PROPN
fnp-2671	335	11	,	,	PUNCT
fnp-2671	335	12	brain	brain	VERB
fnp-2671	335	13	tumour	tumour	NOUN
fnp-2671	335	14	diagnostics	diagnostic	NOUN
fnp-2671	335	15	using	use	VERB
fnp-2671	335	16	a	a	DET
fnp-2671	335	17	dna	dna	PROPN
fnp-2671	335	18	methylation	methylation	NOUN
fnp-2671	335	19	-	-	PUNCT
fnp-2671	335	20	based	base	VERB
fnp-2671	335	21	classifier	classifier	NOUN
fnp-2671	335	22	as	as	ADP
fnp-2671	335	23	a	a	DET
fnp-2671	335	24	diagnostic	diagnostic	ADJ
fnp-2671	335	25	support	support	NOUN
fnp-2671	335	26	tool	tool	NOUN
fnp-2671	335	27	.	.	PUNCT
fnp-2671	336	1	neuropathol	neuropathol	PROPN
fnp-2671	336	2	appl	appl	PROPN
fnp-2671	336	3	neurobiol	neurobiol	PROPN
fnp-2671	336	4	,	,	PUNCT
fnp-2671	336	5	2020	2020	NUM
fnp-2671	336	6	.	.	PUNCT
fnp-2671	337	1	30	30	NUM
fnp-2671	337	2	.	.	PUNCT
fnp-2671	338	1	schwalbe	schwalbe	NOUN
fnp-2671	338	2	,	,	PUNCT
fnp-2671	338	3	e.c	e.c	PROPN
fnp-2671	338	4	.	.	PROPN
fnp-2671	338	5	,	,	PUNCT
fnp-2671	338	6	et	et	PROPN
fnp-2671	338	7	al	al	PROPN
fnp-2671	338	8	.	.	PROPN
fnp-2671	338	9	,	,	PUNCT
fnp-2671	338	10	novel	novel	ADJ
fnp-2671	338	11	molecular	molecular	ADJ
fnp-2671	338	12	subgroups	subgroup	NOUN
fnp-2671	338	13	for	for	ADP
fnp-2671	338	14	clinical	clinical	ADJ
fnp-2671	338	15	classification	classification	NOUN
fnp-2671	338	16	and	and	CCONJ
fnp-2671	338	17	outcome	outcome	NOUN
fnp-2671	338	18	prediction	prediction	NOUN
fnp-2671	338	19	in	in	ADP
fnp-2671	338	20	childhood	childhood	NOUN
fnp-2671	338	21	medulloblastoma	medulloblastoma	NOUN
fnp-2671	338	22	:	:	PUNCT
fnp-2671	338	23	a	a	DET
fnp-2671	338	24	cohort	cohort	NOUN
fnp-2671	338	25	study	study	NOUN
fnp-2671	338	26	.	.	PUNCT
fnp-2671	339	1	lancet	lancet	PROPN
fnp-2671	339	2	oncol	oncol	PROPN
fnp-2671	339	3	,	,	PUNCT
fnp-2671	339	4	2017	2017	NUM
fnp-2671	339	5	.	.	PUNCT
fnp-2671	340	1	18(7	18(7	NUM
fnp-2671	340	2	):	):	PUNCT
fnp-2671	341	1	p.	p.	NOUN
fnp-2671	341	2	958	958	NUM
fnp-2671	341	3	-	-	SYM
fnp-2671	341	4	971	971	NUM
fnp-2671	341	5	.	.	PUNCT
fnp-2671	341	6	31	31	NUM
fnp-2671	341	7	.	.	PUNCT
fnp-2671	342	1	cavalli	cavalli	PROPN
fnp-2671	342	2	,	,	PUNCT
fnp-2671	342	3	f.m.g	f.m.g	PROPN
fnp-2671	342	4	.	.	PROPN
fnp-2671	342	5	,	,	PUNCT
fnp-2671	342	6	et	et	PROPN
fnp-2671	342	7	al	al	PROPN
fnp-2671	342	8	.	.	PROPN
fnp-2671	342	9	,	,	PUNCT
fnp-2671	342	10	intertumoral	intertumoral	ADJ
fnp-2671	342	11	heterogeneity	heterogeneity	NOUN
fnp-2671	342	12	within	within	ADP
fnp-2671	342	13	medulloblastoma	medulloblastoma	ADJ
fnp-2671	342	14	subgroups	subgroup	NOUN
fnp-2671	342	15	.	.	PUNCT
fnp-2671	343	1	cancer	cancer	NOUN
fnp-2671	343	2	cell	cell	NOUN
fnp-2671	343	3	,	,	PUNCT
fnp-2671	343	4	2017	2017	NUM
fnp-2671	343	5	.	.	PUNCT
fnp-2671	344	1	31(6	31(6	NUM
fnp-2671	344	2	):	):	PUNCT
fnp-2671	344	3	p.	p.	NOUN
fnp-2671	344	4	737	737	NUM
fnp-2671	344	5	-	-	SYM
fnp-2671	344	6	754	754	NUM
fnp-2671	344	7	e6	e6	NOUN
fnp-2671	344	8	.	.	PUNCT
fnp-2671	345	1	32	32	NUM
fnp-2671	345	2	.	.	PUNCT
fnp-2671	346	1	northcott	northcott	PROPN
fnp-2671	346	2	,	,	PUNCT
fnp-2671	346	3	p.a	p.a	PROPN
fnp-2671	346	4	.	.	PROPN
fnp-2671	346	5	,	,	PUNCT
fnp-2671	346	6	et	et	PROPN
fnp-2671	346	7	al	al	PROPN
fnp-2671	346	8	.	.	PROPN
fnp-2671	346	9	,	,	PUNCT
fnp-2671	346	10	the	the	DET
fnp-2671	346	11	whole	whole	ADJ
fnp-2671	346	12	-	-	PUNCT
fnp-2671	346	13	genome	genome	NOUN
fnp-2671	346	14	landscape	landscape	NOUN
fnp-2671	346	15	of	of	ADP
fnp-2671	346	16	medulloblastoma	medulloblastoma	ADJ
fnp-2671	346	17	subtypes	subtype	NOUN
fnp-2671	346	18	.	.	PUNCT
fnp-2671	347	1	nature	nature	NOUN
fnp-2671	347	2	,	,	PUNCT
fnp-2671	347	3	2017	2017	NUM
fnp-2671	347	4	.	.	PUNCT
fnp-2671	348	1	547(7663	547(7663	NUM
fnp-2671	348	2	):	):	PUNCT
fnp-2671	348	3	p.	p.	NOUN
fnp-2671	348	4	311	311	NUM
fnp-2671	348	5	-	-	SYM
fnp-2671	348	6	317	317	NUM
fnp-2671	348	7	.	.	PUNCT
fnp-2671	349	1	33	33	NUM
fnp-2671	349	2	.	.	PUNCT
fnp-2671	349	3	gibson	gibson	PROPN
fnp-2671	349	4	,	,	PUNCT
fnp-2671	349	5	p.	p.	PROPN
fnp-2671	349	6	,	,	PUNCT
fnp-2671	349	7	et	et	PROPN
fnp-2671	349	8	al	al	PROPN
fnp-2671	349	9	.	.	PROPN
fnp-2671	349	10	,	,	PUNCT
fnp-2671	349	11	subtypes	subtype	NOUN
fnp-2671	349	12	of	of	ADP
fnp-2671	349	13	medulloblastoma	medulloblastoma	NOUN
fnp-2671	349	14	have	have	VERB
fnp-2671	349	15	distinct	distinct	ADJ
fnp-2671	349	16	developmental	developmental	ADJ
fnp-2671	349	17	origins	origin	NOUN
fnp-2671	349	18	.	.	PUNCT
fnp-2671	350	1	nature	nature	NOUN
fnp-2671	350	2	,	,	PUNCT
fnp-2671	350	3	2010	2010	NUM
fnp-2671	350	4	.	.	PUNCT
fnp-2671	351	1	468(7327	468(7327	NUM
fnp-2671	351	2	):	):	PUNCT
fnp-2671	352	1	p.	p.	NOUN
fnp-2671	352	2	1095	1095	NUM
fnp-2671	352	3	-	-	SYM
fnp-2671	352	4	9	9	NUM
fnp-2671	352	5	.	.	NOUN
fnp-2671	352	6	34	34	NUM
fnp-2671	352	7	.	.	PUNCT
fnp-2671	353	1	cancer	cancer	NOUN
fnp-2671	353	2	genome	genome	NOUN
fnp-2671	353	3	atlas	atlas	PROPN
fnp-2671	353	4	research	research	PROPN
fnp-2671	353	5	,	,	PUNCT
fnp-2671	353	6	n.	n.	NOUN
fnp-2671	353	7	,	,	PUNCT
fnp-2671	353	8	comprehensive	comprehensive	ADJ
fnp-2671	353	9	genomic	genomic	NOUN
fnp-2671	353	10	characterization	characterization	NOUN
fnp-2671	353	11	defines	define	VERB
fnp-2671	353	12	human	human	ADJ
fnp-2671	353	13	glioblastoma	glioblastoma	NOUN
fnp-2671	353	14	genes	gene	NOUN
fnp-2671	353	15	and	and	CCONJ
fnp-2671	353	16	core	core	NOUN
fnp-2671	353	17	pathways	pathway	NOUN
fnp-2671	353	18	.	.	PUNCT
fnp-2671	354	1	nature	nature	NOUN
fnp-2671	354	2	,	,	PUNCT
fnp-2671	354	3	2008	2008	NUM
fnp-2671	354	4	.	.	PUNCT
fnp-2671	355	1	455(7216	455(7216	NUM
fnp-2671	355	2	):	):	PUNCT
fnp-2671	355	3	p.	p.	NOUN
fnp-2671	355	4	1061	1061	NUM
fnp-2671	355	5	-	-	SYM
fnp-2671	355	6	8	8	NUM
fnp-2671	355	7	.	.	NOUN
fnp-2671	355	8	35	35	NUM
fnp-2671	355	9	.	.	PUNCT
fnp-2671	356	1	brennan	brennan	PROPN
fnp-2671	356	2	,	,	PUNCT
fnp-2671	356	3	c.w	c.w	PROPN
fnp-2671	356	4	.	.	PROPN
fnp-2671	356	5	,	,	PUNCT
fnp-2671	356	6	et	et	PROPN
fnp-2671	356	7	al	al	PROPN
fnp-2671	356	8	.	.	PROPN
fnp-2671	356	9	,	,	PUNCT
fnp-2671	356	10	the	the	DET
fnp-2671	356	11	somatic	somatic	ADJ
fnp-2671	356	12	genomic	genomic	ADJ
fnp-2671	356	13	landscape	landscape	NOUN
fnp-2671	356	14	of	of	ADP
fnp-2671	356	15	glioblastoma	glioblastoma	NOUN
fnp-2671	356	16	.	.	PUNCT
fnp-2671	357	1	cell	cell	NOUN
fnp-2671	357	2	,	,	PUNCT
fnp-2671	357	3	2013	2013	NUM
fnp-2671	357	4	.	.	PUNCT
fnp-2671	358	1	155(2	155(2	NUM
fnp-2671	358	2	):	):	PUNCT
fnp-2671	358	3	p.	p.	NOUN
fnp-2671	358	4	462	462	NUM
fnp-2671	359	1	-	-	NOUN
fnp-2671	359	2	77	77	NUM
fnp-2671	359	3	.	.	PUNCT
fnp-2671	360	1	36	36	NUM
fnp-2671	360	2	.	.	PUNCT
fnp-2671	361	1	cancer	cancer	NOUN
fnp-2671	361	2	genome	genome	NOUN
fnp-2671	361	3	atlas	atlas	PROPN
fnp-2671	361	4	research	research	PROPN
fnp-2671	361	5	,	,	PUNCT
fnp-2671	361	6	n.	n.	PROPN
fnp-2671	361	7	,	,	PUNCT
fnp-2671	361	8	et	et	PROPN
fnp-2671	361	9	al	al	PROPN
fnp-2671	361	10	.	.	PROPN
fnp-2671	361	11	,	,	PUNCT
fnp-2671	361	12	comprehensive	comprehensive	ADJ
fnp-2671	361	13	,	,	PUNCT
fnp-2671	361	14	integrative	integrative	ADJ
fnp-2671	361	15	genomic	genomic	ADJ
fnp-2671	361	16	analysis	analysis	NOUN
fnp-2671	361	17	of	of	ADP
fnp-2671	361	18	diffuse	diffuse	ADJ
fnp-2671	361	19	lower	low	ADJ
fnp-2671	361	20	-	-	PUNCT
fnp-2671	361	21	grade	grade	NOUN
fnp-2671	361	22	gliomas	glioma	NOUN
fnp-2671	361	23	.	.	PUNCT
fnp-2671	362	1	n	n	X
fnp-2671	362	2	engl	engl	PROPN
fnp-2671	362	3	j	j	PROPN
fnp-2671	362	4	med	med	PROPN
fnp-2671	362	5	,	,	PUNCT
fnp-2671	362	6	2015	2015	NUM
fnp-2671	362	7	.	.	PUNCT
fnp-2671	363	1	372(26	372(26	NUM
fnp-2671	363	2	):	):	PUNCT
fnp-2671	364	1	p.	p.	NOUN
fnp-2671	364	2	2481	2481	NUM
fnp-2671	364	3	-	-	SYM
fnp-2671	364	4	98	98	NUM
fnp-2671	364	5	.	.	PUNCT
fnp-2671	364	6	37	37	NUM
fnp-2671	364	7	.	.	PUNCT
fnp-2671	365	1	ceccarelli	ceccarelli	PROPN
fnp-2671	365	2	,	,	PUNCT
fnp-2671	365	3	m.	m.	NOUN
fnp-2671	365	4	,	,	PUNCT
fnp-2671	365	5	et	et	PROPN
fnp-2671	365	6	al	al	PROPN
fnp-2671	365	7	.	.	PROPN
fnp-2671	365	8	,	,	PUNCT
fnp-2671	365	9	molecular	molecular	ADJ
fnp-2671	365	10	profiling	profiling	NOUN
fnp-2671	365	11	reveals	reveal	VERB
fnp-2671	365	12	biologically	biologically	ADV
fnp-2671	365	13	discrete	discrete	ADJ
fnp-2671	365	14	subsets	subset	NOUN
fnp-2671	365	15	and	and	CCONJ
fnp-2671	365	16	pathways	pathway	NOUN
fnp-2671	365	17	of	of	ADP
fnp-2671	365	18	progression	progression	NOUN
fnp-2671	365	19	in	in	ADP
fnp-2671	365	20	diffuse	diffuse	NOUN
fnp-2671	365	21	glioma	glioma	NOUN
fnp-2671	365	22	.	.	PUNCT
fnp-2671	366	1	cell	cell	NOUN
fnp-2671	366	2	,	,	PUNCT
fnp-2671	366	3	2016	2016	NUM
fnp-2671	366	4	.	.	PUNCT
fnp-2671	367	1	164(3	164(3	NUM
fnp-2671	367	2	):	):	PUNCT
fnp-2671	367	3	p.	p.	NOUN
fnp-2671	367	4	550	550	NUM
fnp-2671	367	5	-	-	SYM
fnp-2671	367	6	63	63	NUM
fnp-2671	367	7	.	.	PUNCT
fnp-2671	367	8	38	38	NUM
fnp-2671	367	9	.	.	PUNCT
fnp-2671	368	1	johnson	johnson	PROPN
fnp-2671	368	2	,	,	PUNCT
fnp-2671	368	3	b.e	b.e	PROPN
fnp-2671	368	4	.	.	PROPN
fnp-2671	368	5	,	,	PUNCT
fnp-2671	368	6	et	et	PROPN
fnp-2671	368	7	al	al	PROPN
fnp-2671	368	8	.	.	PROPN
fnp-2671	368	9	,	,	PUNCT
fnp-2671	368	10	mutational	mutational	ADJ
fnp-2671	368	11	analysis	analysis	NOUN
fnp-2671	368	12	reveals	reveal	VERB
fnp-2671	368	13	the	the	DET
fnp-2671	368	14	origin	origin	NOUN
fnp-2671	368	15	and	and	CCONJ
fnp-2671	368	16	therapy	therapy	NOUN
fnp-2671	368	17	-	-	PUNCT
fnp-2671	368	18	driven	drive	VERB
fnp-2671	368	19	evolution	evolution	NOUN
fnp-2671	368	20	of	of	ADP
fnp-2671	368	21	recurrent	recurrent	ADJ
fnp-2671	368	22	glioma	glioma	NOUN
fnp-2671	368	23	.	.	PUNCT
fnp-2671	369	1	science	science	NOUN
fnp-2671	369	2	,	,	PUNCT
fnp-2671	369	3	2014	2014	NUM
fnp-2671	369	4	.	.	PUNCT
fnp-2671	370	1	343(6167	343(6167	NUM
fnp-2671	370	2	):	):	PUNCT
fnp-2671	371	1	p.	p.	NOUN
fnp-2671	371	2	189	189	NUM
fnp-2671	371	3	-	-	SYM
fnp-2671	371	4	193	193	NUM
fnp-2671	371	5	.	.	PUNCT
fnp-2671	371	6	39	39	NUM
fnp-2671	371	7	.	.	PUNCT
fnp-2671	372	1	van	van	PROPN
fnp-2671	372	2	thuijl	thuijl	PROPN
fnp-2671	372	3	,	,	PUNCT
fnp-2671	372	4	h.f	h.f	PROPN
fnp-2671	372	5	.	.	PROPN
fnp-2671	372	6	,	,	PUNCT
fnp-2671	372	7	et	et	PROPN
fnp-2671	372	8	al	al	PROPN
fnp-2671	372	9	.	.	PROPN
fnp-2671	372	10	,	,	PUNCT
fnp-2671	372	11	evolution	evolution	NOUN
fnp-2671	372	12	of	of	ADP
fnp-2671	372	13	dna	dna	PROPN
fnp-2671	372	14	repair	repair	NOUN
fnp-2671	372	15	defects	defect	NOUN
fnp-2671	372	16	during	during	ADP
fnp-2671	372	17	malignant	malignant	ADJ
fnp-2671	372	18	progression	progression	NOUN
fnp-2671	372	19	of	of	ADP
fnp-2671	372	20	low	low	ADJ
fnp-2671	372	21	-	-	PUNCT
fnp-2671	372	22	grade	grade	NOUN
fnp-2671	372	23	gliomas	glioma	NOUN
fnp-2671	372	24	after	after	ADP
fnp-2671	372	25	temozolomide	temozolomide	NOUN
fnp-2671	372	26	treatment	treatment	NOUN
fnp-2671	372	27	.	.	PUNCT
fnp-2671	373	1	acta	acta	PROPN
fnp-2671	373	2	neuropathol	neuropathol	PROPN
fnp-2671	373	3	,	,	PUNCT
fnp-2671	373	4	2015	2015	NUM
fnp-2671	373	5	.	.	PUNCT
fnp-2671	374	1	129(4	129(4	NUM
fnp-2671	374	2	):	):	PUNCT
fnp-2671	374	3	p.	p.	NOUN
fnp-2671	374	4	597	597	NUM
fnp-2671	374	5	-	-	SYM
fnp-2671	374	6	607	607	NUM
fnp-2671	374	7	.	.	PUNCT
fnp-2671	374	8	40	40	NUM
fnp-2671	374	9	.	.	PUNCT
fnp-2671	375	1	shirahata	shirahata	NOUN
fnp-2671	375	2	,	,	PUNCT
fnp-2671	375	3	m.	m.	NOUN
fnp-2671	375	4	,	,	PUNCT
fnp-2671	375	5	et	et	PROPN
fnp-2671	375	6	al	al	PROPN
fnp-2671	375	7	.	.	PROPN
fnp-2671	375	8	,	,	PUNCT
fnp-2671	375	9	novel	novel	PROPN
fnp-2671	375	10	,	,	PUNCT
fnp-2671	375	11	improved	improve	VERB
fnp-2671	375	12	grading	grade	VERB
fnp-2671	375	13	system(s	system(s	NOUN
fnp-2671	375	14	)	)	PUNCT
fnp-2671	375	15	for	for	ADP
fnp-2671	375	16	idh	idh	NOUN
fnp-2671	375	17	-	-	PUNCT
fnp-2671	375	18	mutant	mutant	NOUN
fnp-2671	375	19	astrocytic	astrocytic	ADJ
fnp-2671	375	20	gliomas	glioma	NOUN
fnp-2671	375	21	.	.	PUNCT
fnp-2671	376	1	acta	acta	PROPN
fnp-2671	376	2	neuropathol	neuropathol	PROPN
fnp-2671	376	3	,	,	PUNCT
fnp-2671	376	4	2018	2018	NUM
fnp-2671	376	5	.	.	PUNCT
fnp-2671	377	1	136(1	136(1	NUM
fnp-2671	377	2	):	):	PUNCT
fnp-2671	378	1	p.	p.	NOUN
fnp-2671	378	2	153	153	NUM
fnp-2671	378	3	-	-	SYM
fnp-2671	378	4	166	166	NUM
fnp-2671	378	5	.	.	PUNCT
fnp-2671	378	6	41	41	NUM
fnp-2671	378	7	.	.	PUNCT
fnp-2671	379	1	claes	claes	PROPN
fnp-2671	379	2	,	,	PUNCT
fnp-2671	379	3	a.	a.	PROPN
fnp-2671	379	4	,	,	PUNCT
fnp-2671	379	5	a.j	a.j	PROPN
fnp-2671	379	6	.	.	PROPN
fnp-2671	379	7	idema	idema	PROPN
fnp-2671	379	8	,	,	PUNCT
fnp-2671	379	9	and	and	CCONJ
fnp-2671	379	10	p.	p.	NOUN
fnp-2671	379	11	wesseling	wesseling	NOUN
fnp-2671	379	12	,	,	PUNCT
fnp-2671	379	13	diffuse	diffuse	VERB
fnp-2671	379	14	glioma	glioma	NOUN
fnp-2671	379	15	growth	growth	NOUN
fnp-2671	379	16	:	:	PUNCT
fnp-2671	379	17	a	a	DET
fnp-2671	379	18	guerilla	guerilla	NOUN
fnp-2671	379	19	war	war	NOUN
fnp-2671	379	20	.	.	PUNCT
fnp-2671	380	1	acta	acta	PROPN
fnp-2671	380	2	neuropathol	neuropathol	PROPN
fnp-2671	380	3	,	,	PUNCT
fnp-2671	380	4	2007	2007	NUM
fnp-2671	380	5	.	.	PUNCT
fnp-2671	381	1	114(5	114(5	NUM
fnp-2671	381	2	):	):	PUNCT
fnp-2671	382	1	p.	p.	NOUN
fnp-2671	382	2	443	443	NUM
fnp-2671	382	3	-	-	SYM
fnp-2671	382	4	58	58	NUM
fnp-2671	382	5	.	.	PUNCT
fnp-2671	383	1	42	42	NUM
fnp-2671	383	2	.	.	PUNCT
fnp-2671	384	1	venkatesh	venkatesh	PROPN
fnp-2671	384	2	,	,	PUNCT
fnp-2671	384	3	h.s	h.s	PROPN
fnp-2671	384	4	.	.	PROPN
fnp-2671	384	5	,	,	PUNCT
fnp-2671	384	6	et	et	PROPN
fnp-2671	384	7	al	al	PROPN
fnp-2671	384	8	.	.	PROPN
fnp-2671	384	9	,	,	PUNCT
fnp-2671	384	10	neuronal	neuronal	ADJ
fnp-2671	384	11	activity	activity	NOUN
fnp-2671	384	12	promotes	promote	VERB
fnp-2671	384	13	glioma	glioma	ADJ
fnp-2671	384	14	growth	growth	NOUN
fnp-2671	384	15	through	through	ADP
fnp-2671	384	16	neuroligin-3	neuroligin-3	PRON
fnp-2671	384	17	secretion	secretion	NOUN
fnp-2671	384	18	.	.	PUNCT
fnp-2671	385	1	cell	cell	NOUN
fnp-2671	385	2	,	,	PUNCT
fnp-2671	385	3	2015	2015	NUM
fnp-2671	385	4	.	.	PUNCT
fnp-2671	386	1	161(4	161(4	NUM
fnp-2671	386	2	):	):	PUNCT
fnp-2671	387	1	p.	p.	NOUN
fnp-2671	387	2	803	803	NUM
fnp-2671	387	3	-	-	SYM
fnp-2671	387	4	16	16	NUM
fnp-2671	387	5	.	.	PUNCT
fnp-2671	387	6	43	43	NUM
fnp-2671	387	7	.	.	PUNCT
fnp-2671	388	1	venkatesh	venkatesh	PROPN
fnp-2671	388	2	,	,	PUNCT
fnp-2671	388	3	h.s	h.s	PROPN
fnp-2671	388	4	.	.	PROPN
fnp-2671	388	5	,	,	PUNCT
fnp-2671	388	6	et	et	PROPN
fnp-2671	388	7	al	al	PROPN
fnp-2671	388	8	.	.	PROPN
fnp-2671	388	9	,	,	PUNCT
fnp-2671	388	10	targeting	target	VERB
fnp-2671	388	11	neuronal	neuronal	ADJ
fnp-2671	388	12	activity	activity	NOUN
fnp-2671	388	13	-	-	PUNCT
fnp-2671	388	14	regulated	regulate	VERB
fnp-2671	388	15	neuroligin-3	neuroligin-3	PRON
fnp-2671	388	16	dependency	dependency	NOUN
fnp-2671	388	17	in	in	ADP
fnp-2671	388	18	high	high	ADJ
fnp-2671	388	19	-	-	PUNCT
fnp-2671	388	20	grade	grade	NOUN
fnp-2671	388	21	glioma	glioma	NOUN
fnp-2671	388	22	.	.	PUNCT
fnp-2671	389	1	nature	nature	NOUN
fnp-2671	389	2	,	,	PUNCT
fnp-2671	389	3	2017	2017	NUM
fnp-2671	389	4	.	.	PUNCT
fnp-2671	390	1	549(7673	549(7673	NUM
fnp-2671	390	2	):	):	PUNCT
fnp-2671	391	1	p.	p.	NOUN
fnp-2671	391	2	533	533	NUM
fnp-2671	391	3	-	-	SYM
fnp-2671	391	4	537	537	NUM
fnp-2671	391	5	.	.	NUM
fnp-2671	391	6	44	44	NUM
fnp-2671	391	7	.	.	PUNCT
fnp-2671	392	1	osswald	osswald	ADJ
fnp-2671	392	2	,	,	PUNCT
fnp-2671	392	3	m.	m.	NOUN
fnp-2671	392	4	,	,	PUNCT
fnp-2671	392	5	et	et	PROPN
fnp-2671	392	6	al	al	PROPN
fnp-2671	392	7	.	.	PROPN
fnp-2671	392	8	,	,	PUNCT
fnp-2671	392	9	brain	brain	VERB
fnp-2671	392	10	tumour	tumour	NOUN
fnp-2671	392	11	cells	cell	NOUN
fnp-2671	392	12	interconnect	interconnect	VERB
fnp-2671	392	13	to	to	ADP
fnp-2671	392	14	a	a	DET
fnp-2671	392	15	functional	functional	ADJ
fnp-2671	392	16	and	and	CCONJ
fnp-2671	392	17	resistant	resistant	ADJ
fnp-2671	392	18	network	network	NOUN
fnp-2671	392	19	.	.	PUNCT
fnp-2671	393	1	nature	nature	NOUN
fnp-2671	393	2	,	,	PUNCT
fnp-2671	393	3	2015	2015	NUM
fnp-2671	393	4	.	.	PUNCT
fnp-2671	394	1	528(7580	528(7580	NUM
fnp-2671	394	2	):	):	PUNCT
fnp-2671	395	1	p.	p.	NOUN
fnp-2671	395	2	93	93	NUM
fnp-2671	395	3	-	-	SYM
fnp-2671	395	4	8	8	NUM
fnp-2671	395	5	.	.	X
fnp-2671	395	6	45	45	NUM
fnp-2671	395	7	.	.	PUNCT
fnp-2671	396	1	gimple	gimple	PROPN
fnp-2671	396	2	,	,	PUNCT
fnp-2671	396	3	r.c	r.c	PROPN
fnp-2671	396	4	.	.	PROPN
fnp-2671	396	5	,	,	PUNCT
fnp-2671	396	6	et	et	PROPN
fnp-2671	396	7	al	al	PROPN
fnp-2671	396	8	.	.	PROPN
fnp-2671	396	9	,	,	PUNCT
fnp-2671	396	10	glioblastoma	glioblastoma	NOUN
fnp-2671	396	11	stem	stem	NOUN
fnp-2671	396	12	cells	cell	NOUN
fnp-2671	396	13	:	:	PUNCT
fnp-2671	396	14	lessons	lesson	NOUN
fnp-2671	396	15	from	from	ADP
fnp-2671	396	16	the	the	DET
fnp-2671	396	17	tumor	tumor	NOUN
fnp-2671	396	18	hierarchy	hierarchy	NOUN
fnp-2671	396	19	in	in	ADP
fnp-2671	396	20	a	a	DET
fnp-2671	396	21	lethal	lethal	ADJ
fnp-2671	396	22	cancer	cancer	NOUN
fnp-2671	396	23	.	.	PUNCT
fnp-2671	397	1	genes	gene	NOUN
fnp-2671	397	2	dev	dev	PROPN
fnp-2671	397	3	,	,	PUNCT
fnp-2671	397	4	2019	2019	NUM
fnp-2671	397	5	.	.	PUNCT
fnp-2671	398	1	33(11	33(11	NUM
fnp-2671	398	2	-	-	SYM
fnp-2671	398	3	12	12	NUM
fnp-2671	398	4	):	):	PUNCT
fnp-2671	398	5	p.	p.	NOUN
fnp-2671	398	6	591	591	NUM
fnp-2671	398	7	-	-	SYM
fnp-2671	398	8	609	609	NUM
fnp-2671	398	9	.	.	PUNCT
fnp-2671	399	1	46	46	NUM
fnp-2671	399	2	.	.	PUNCT
fnp-2671	400	1	zhao	zhao	PROPN
fnp-2671	400	2	,	,	PUNCT
fnp-2671	400	3	j.	j.	PROPN
fnp-2671	400	4	,	,	PUNCT
fnp-2671	400	5	et	et	PROPN
fnp-2671	400	6	al	al	PROPN
fnp-2671	400	7	.	.	PROPN
fnp-2671	400	8	,	,	PUNCT
fnp-2671	400	9	immune	immune	ADJ
fnp-2671	400	10	and	and	CCONJ
fnp-2671	400	11	genomic	genomic	NOUN
fnp-2671	400	12	correlates	correlate	VERB
fnp-2671	400	13	of	of	ADP
fnp-2671	400	14	response	response	NOUN
fnp-2671	400	15	to	to	ADP
fnp-2671	400	16	anti	anti	ADJ
fnp-2671	400	17	-	-	ADJ
fnp-2671	400	18	pd-1	pd-1	ADJ
fnp-2671	400	19	immunotherapy	immunotherapy	NOUN
fnp-2671	400	20	in	in	ADP
fnp-2671	400	21	glioblastoma	glioblastoma	NOUN
fnp-2671	400	22	.	.	PUNCT
fnp-2671	401	1	nat	nat	PROPN
fnp-2671	401	2	med	med	PROPN
fnp-2671	401	3	,	,	PUNCT
fnp-2671	401	4	2019	2019	NUM
fnp-2671	401	5	.	.	PUNCT
fnp-2671	402	1	25(3	25(3	NUM
fnp-2671	402	2	):	):	PUNCT
fnp-2671	402	3	p.	p.	NOUN
fnp-2671	402	4	462	462	NUM
fnp-2671	402	5	-	-	SYM
fnp-2671	402	6	469	469	NUM
fnp-2671	402	7	.	.	PUNCT
fnp-2671	403	1	47	47	NUM
fnp-2671	403	2	.	.	PUNCT
fnp-2671	404	1	cloughesy	cloughesy	PROPN
fnp-2671	404	2	,	,	PUNCT
fnp-2671	404	3	t.f	t.f	PROPN
fnp-2671	404	4	.	.	PROPN
fnp-2671	404	5	,	,	PUNCT
fnp-2671	404	6	et	et	PROPN
fnp-2671	404	7	al	al	PROPN
fnp-2671	404	8	.	.	PROPN
fnp-2671	404	9	,	,	PUNCT
fnp-2671	404	10	neoadjuvant	neoadjuvant	ADJ
fnp-2671	404	11	anti	anti	ADJ
fnp-2671	404	12	-	-	ADJ
fnp-2671	404	13	pd-1	pd-1	ADJ
fnp-2671	404	14	immunotherapy	immunotherapy	NOUN
fnp-2671	404	15	promotes	promote	VERB
fnp-2671	404	16	a	a	DET
fnp-2671	404	17	survival	survival	NOUN
fnp-2671	404	18	benefit	benefit	NOUN
fnp-2671	404	19	with	with	ADP
fnp-2671	404	20	intratumoral	intratumoral	ADJ
fnp-2671	404	21	and	and	CCONJ
fnp-2671	404	22	systemic	systemic	ADJ
fnp-2671	404	23	immune	immune	ADJ
fnp-2671	404	24	responses	response	NOUN
fnp-2671	404	25	in	in	ADP
fnp-2671	404	26	recurrent	recurrent	ADJ
fnp-2671	404	27	glioblastoma	glioblastoma	NOUN
fnp-2671	404	28	.	.	PUNCT
fnp-2671	405	1	nat	nat	PROPN
fnp-2671	405	2	med	med	PROPN
fnp-2671	405	3	,	,	PUNCT
fnp-2671	405	4	2019	2019	NUM
fnp-2671	405	5	.	.	PUNCT
fnp-2671	406	1	25(3	25(3	NUM
fnp-2671	406	2	):	):	PUNCT
fnp-2671	406	3	p.	p.	NOUN
fnp-2671	406	4	477	477	NUM
fnp-2671	406	5	-	-	SYM
fnp-2671	406	6	486	486	NUM
fnp-2671	406	7	.	.	PUNCT
fnp-2671	407	1	48	48	NUM
fnp-2671	407	2	.	.	PUNCT
fnp-2671	408	1	best	good	ADJ
fnp-2671	408	2	,	,	PUNCT
fnp-2671	408	3	m.g	m.g	PROPN
fnp-2671	408	4	.	.	PROPN
fnp-2671	408	5	,	,	PUNCT
fnp-2671	408	6	et	et	PROPN
fnp-2671	408	7	al	al	PROPN
fnp-2671	408	8	.	.	PROPN
fnp-2671	408	9	,	,	PUNCT
fnp-2671	408	10	liquid	liquid	ADJ
fnp-2671	408	11	biopsies	biopsy	NOUN
fnp-2671	408	12	in	in	ADP
fnp-2671	408	13	patients	patient	NOUN
fnp-2671	408	14	with	with	ADP
fnp-2671	408	15	diffuse	diffuse	NOUN
fnp-2671	408	16	glioma	glioma	NOUN
fnp-2671	408	17	.	.	PUNCT
fnp-2671	409	1	acta	acta	PROPN
fnp-2671	409	2	neuropathol	neuropathol	PROPN
fnp-2671	409	3	,	,	PUNCT
fnp-2671	409	4	2015	2015	NUM
fnp-2671	409	5	.	.	PUNCT
fnp-2671	410	1	129(6	129(6	NUM
fnp-2671	410	2	):	):	PUNCT
fnp-2671	410	3	p.	p.	NOUN
fnp-2671	410	4	849	849	NUM
fnp-2671	410	5	-	-	SYM
fnp-2671	410	6	65	65	NUM
fnp-2671	410	7	.	.	PUNCT
fnp-2671	410	8	49	49	NUM
fnp-2671	410	9	.	.	PUNCT
fnp-2671	411	1	van	van	PROPN
fnp-2671	411	2	der	der	PROPN
fnp-2671	411	3	pol	pol	PROPN
fnp-2671	411	4	,	,	PUNCT
fnp-2671	411	5	y.	y.	PROPN
fnp-2671	411	6	and	and	CCONJ
fnp-2671	411	7	f.	f.	PROPN
fnp-2671	411	8	mouliere	mouliere	PROPN
fnp-2671	411	9	,	,	PUNCT
fnp-2671	411	10	toward	toward	ADP
fnp-2671	411	11	the	the	DET
fnp-2671	411	12	early	early	ADJ
fnp-2671	411	13	detection	detection	NOUN
fnp-2671	411	14	of	of	ADP
fnp-2671	411	15	cancer	cancer	NOUN
fnp-2671	411	16	by	by	ADP
fnp-2671	411	17	decoding	decode	VERB
fnp-2671	411	18	the	the	DET
fnp-2671	411	19	epigenetic	epigenetic	ADJ
fnp-2671	411	20	and	and	CCONJ
fnp-2671	411	21	environmental	environmental	ADJ
fnp-2671	411	22	fingerprints	fingerprint	NOUN
fnp-2671	411	23	of	of	ADP
fnp-2671	411	24	cell	cell	NOUN
fnp-2671	411	25	-	-	PUNCT
fnp-2671	411	26	free	free	ADJ
fnp-2671	411	27	dna	dna	NOUN
fnp-2671	411	28	.	.	PUNCT
fnp-2671	412	1	cancer	cancer	NOUN
fnp-2671	412	2	cell	cell	NOUN
fnp-2671	412	3	,	,	PUNCT
fnp-2671	412	4	2019	2019	NUM
fnp-2671	412	5	.	.	PUNCT
fnp-2671	413	1	36(4	36(4	NUM
fnp-2671	413	2	):	):	PUNCT
fnp-2671	414	1	p.	p.	NOUN
fnp-2671	414	2	350	350	NUM
fnp-2671	414	3	-	-	SYM
fnp-2671	414	4	368	368	NUM
fnp-2671	414	5	.	.	PUNCT
fnp-2671	415	1	50	50	NUM
fnp-2671	415	2	.	.	PUNCT
fnp-2671	416	1	kristensen	kristensen	PROPN
fnp-2671	416	2	,	,	PUNCT
fnp-2671	416	3	b.w	b.w	PROPN
fnp-2671	416	4	.	.	PROPN
fnp-2671	416	5	,	,	PUNCT
fnp-2671	416	6	et	et	PROPN
fnp-2671	416	7	al	al	PROPN
fnp-2671	416	8	.	.	PROPN
fnp-2671	416	9	,	,	PUNCT
fnp-2671	416	10	molecular	molecular	ADJ
fnp-2671	416	11	pathology	pathology	NOUN
fnp-2671	416	12	of	of	ADP
fnp-2671	416	13	tumors	tumor	NOUN
fnp-2671	416	14	of	of	ADP
fnp-2671	416	15	the	the	DET
fnp-2671	416	16	central	central	ADJ
fnp-2671	416	17	nervous	nervous	ADJ
fnp-2671	416	18	system	system	NOUN
fnp-2671	416	19	.	.	PUNCT
fnp-2671	417	1	ann	ann	PROPN
fnp-2671	417	2	oncol	oncol	PROPN
fnp-2671	417	3	,	,	PUNCT
fnp-2671	417	4	2019	2019	NUM
fnp-2671	417	5	.	.	PUNCT
fnp-2671	418	1	30(8	30(8	NUM
fnp-2671	418	2	):	):	PUNCT
fnp-2671	418	3	p.	p.	NOUN
fnp-2671	418	4	1265	1265	NUM
fnp-2671	418	5	-	-	SYM
fnp-2671	418	6	1278	1278	NUM
fnp-2671	418	7	.	.	PUNCT
fnp-2671	419	1	51	51	NUM
fnp-2671	419	2	.	.	PUNCT
fnp-2671	419	3	priesterbach	priesterbach	NOUN
fnp-2671	419	4	-	-	PUNCT
fnp-2671	419	5	ackley	ackley	PROPN
fnp-2671	419	6	,	,	PUNCT
fnp-2671	419	7	l.p	l.p	PROPN
fnp-2671	419	8	.	.	PROPN
fnp-2671	419	9	,	,	PUNCT
fnp-2671	419	10	et	et	PROPN
fnp-2671	419	11	al	al	PROPN
fnp-2671	419	12	.	.	PROPN
fnp-2671	419	13	,	,	PUNCT
fnp-2671	419	14	molecular	molecular	ADJ
fnp-2671	419	15	tools	tool	NOUN
fnp-2671	419	16	for	for	ADP
fnp-2671	419	17	the	the	DET
fnp-2671	419	18	pathologic	pathologic	ADJ
fnp-2671	419	19	diagnosis	diagnosis	NOUN
fnp-2671	419	20	of	of	ADP
fnp-2671	419	21	central	central	ADJ
fnp-2671	419	22	nervous	nervous	ADJ
fnp-2671	419	23	system	system	NOUN
fnp-2671	419	24	tumors	tumor	NOUN
fnp-2671	419	25	.	.	PUNCT
fnp-2671	420	1	neurooncol	neurooncol	ADJ
fnp-2671	420	2	pract	pract	NOUN
fnp-2671	420	3	,	,	PUNCT
fnp-2671	420	4	2019	2019	NUM
fnp-2671	420	5	.	.	PUNCT
fnp-2671	421	1	6(1	6(1	NUM
fnp-2671	421	2	):	):	PUNCT
fnp-2671	422	1	p.	p.	NOUN
fnp-2671	422	2	4	4	NUM
fnp-2671	422	3	-	-	SYM
fnp-2671	422	4	16	16	NUM
fnp-2671	422	5	.	.	PUNCT
fnp-2671	422	6	52	52	NUM
fnp-2671	422	7	.	.	PUNCT
fnp-2671	423	1	paulus	paulus	PROPN
fnp-2671	423	2	,	,	PUNCT
fnp-2671	423	3	w.	w.	PROPN
fnp-2671	423	4	,	,	PUNCT
fnp-2671	423	5	heireca	heireca	PROPN
fnp-2671	423	6	!	!	PUNCT
fnp-2671	424	1	the	the	DET
fnp-2671	424	2	heidelberg	heidelberg	PROPN
fnp-2671	424	3	revolution	revolution	PROPN
fnp-2671	424	4	of	of	ADP
fnp-2671	424	5	cancer	cancer	NOUN
fnp-2671	424	6	classification	classification	NOUN
fnp-2671	424	7	and	and	CCONJ
fnp-2671	424	8	what	what	PRON
fnp-2671	424	9	it	it	PRON
fnp-2671	424	10	means	mean	VERB
fnp-2671	424	11	for	for	ADP
fnp-2671	424	12	neurooncology	neurooncology	NOUN
fnp-2671	424	13	and	and	CCONJ
fnp-2671	424	14	neuropathology	neuropathology	NOUN
fnp-2671	424	15	.	.	PUNCT
fnp-2671	425	1	acta	acta	PROPN
fnp-2671	425	2	neuropathol	neuropathol	PROPN
fnp-2671	425	3	,	,	PUNCT
fnp-2671	425	4	2018	2018	NUM
fnp-2671	425	5	.	.	PUNCT
fnp-2671	426	1	136(2	136(2	NUM
fnp-2671	426	2	):	):	PUNCT
fnp-2671	427	1	p.	p.	NOUN
fnp-2671	427	2	177	177	NUM
fnp-2671	427	3	-	-	SYM
fnp-2671	427	4	179	179	NUM
fnp-2671	427	5	.	.	PUNCT
fnp-2671	427	6	53	53	NUM
fnp-2671	427	7	.	.	PUNCT
fnp-2671	427	8	wesseling	wesseling	NOUN
fnp-2671	427	9	,	,	PUNCT
fnp-2671	427	10	p.	p.	NOUN
fnp-2671	427	11	,	,	PUNCT
fnp-2671	427	12	the	the	DET
fnp-2671	427	13	abcs	abc	NOUN
fnp-2671	427	14	of	of	ADP
fnp-2671	427	15	molecular	molecular	ADJ
fnp-2671	427	16	diagnostic	diagnostic	ADJ
fnp-2671	427	17	testing	testing	NOUN
fnp-2671	427	18	of	of	ADP
fnp-2671	427	19	cns	cns	NOUN
fnp-2671	427	20	tumors	tumor	NOUN
fnp-2671	427	21	:	:	PUNCT
fnp-2671	427	22	acceptance	acceptance	NOUN
fnp-2671	427	23	,	,	PUNCT
fnp-2671	427	24	benefits	benefit	NOUN
fnp-2671	427	25	,	,	PUNCT
fnp-2671	427	26	costs	cost	NOUN
fnp-2671	427	27	.	.	PUNCT
fnp-2671	428	1	neuro	neuro	PROPN
fnp-2671	428	2	oncol	oncol	PROPN
fnp-2671	428	3	,	,	PUNCT
fnp-2671	428	4	2019	2019	NUM
fnp-2671	428	5	.	.	PUNCT
fnp-2671	429	1	21(5	21(5	NUM
fnp-2671	429	2	):	):	PUNCT
fnp-2671	429	3	p.	p.	NOUN
fnp-2671	429	4	559	559	NUM
fnp-2671	429	5	-	-	SYM
fnp-2671	429	6	561	561	NUM
fnp-2671	429	7	.	.	PUNCT
fnp-2671	430	1	54	54	NUM
fnp-2671	430	2	.	.	PUNCT
fnp-2671	431	1	karimi	karimi	PROPN
fnp-2671	431	2	,	,	PUNCT
fnp-2671	431	3	s.	s.	PROPN
fnp-2671	431	4	,	,	PUNCT
fnp-2671	431	5	et	et	PROPN
fnp-2671	431	6	al	al	PROPN
fnp-2671	431	7	.	.	PROPN
fnp-2671	431	8	,	,	PUNCT
fnp-2671	431	9	the	the	DET
fnp-2671	431	10	central	central	ADJ
fnp-2671	431	11	nervous	nervous	ADJ
fnp-2671	431	12	system	system	NOUN
fnp-2671	431	13	tumor	tumor	NOUN
fnp-2671	431	14	methylation	methylation	NOUN
fnp-2671	431	15	classifier	classifier	NOUN
fnp-2671	431	16	changes	change	VERB
fnp-2671	431	17	neuro	neuro	NOUN
fnp-2671	431	18	-	-	PUNCT
fnp-2671	431	19	oncology	oncology	NOUN
fnp-2671	431	20	practice	practice	NOUN
fnp-2671	431	21	for	for	ADP
fnp-2671	431	22	challenging	challenge	VERB
fnp-2671	431	23	brain	brain	NOUN
fnp-2671	431	24	tumor	tumor	NOUN
fnp-2671	431	25	diagnoses	diagnosis	NOUN
fnp-2671	431	26	and	and	CCONJ
fnp-2671	431	27	directly	directly	ADV
fnp-2671	431	28	impacts	impact	VERB
fnp-2671	431	29	patient	patient	ADJ
fnp-2671	431	30	care	care	NOUN
fnp-2671	431	31	.	.	PUNCT
fnp-2671	432	1	clin	clin	PROPN
fnp-2671	432	2	epigenetics	epigenetics	PROPN
fnp-2671	432	3	,	,	PUNCT
fnp-2671	432	4	2019	2019	NUM
fnp-2671	432	5	.	.	PUNCT
fnp-2671	433	1	11(1	11(1	NUM
fnp-2671	433	2	):	):	PUNCT
fnp-2671	433	3	p.	p.	NOUN
fnp-2671	433	4	185	185	NUM
fnp-2671	433	5	.	.	PUNCT
fnp-2671	434	1	55	55	NUM
fnp-2671	434	2	.	.	X
fnp-2671	434	3	louis	louis	PROPN
fnp-2671	434	4	,	,	PUNCT
fnp-2671	434	5	d.n	d.n	PROPN
fnp-2671	434	6	.	.	PROPN
fnp-2671	434	7	,	,	PUNCT
fnp-2671	434	8	et	et	PROPN
fnp-2671	434	9	al	al	PROPN
fnp-2671	434	10	.	.	PROPN
fnp-2671	434	11	,	,	PUNCT
fnp-2671	434	12	cimpact	cimpact	NOUN
fnp-2671	434	13	-	-	PUNCT
fnp-2671	434	14	now	now	ADV
fnp-2671	434	15	:	:	PUNCT
fnp-2671	434	16	a	a	DET
fnp-2671	434	17	practical	practical	ADJ
fnp-2671	434	18	summary	summary	NOUN
fnp-2671	434	19	of	of	ADP
fnp-2671	434	20	diagnostic	diagnostic	ADJ
fnp-2671	434	21	points	point	NOUN
fnp-2671	434	22	from	from	ADP
fnp-2671	434	23	round	round	ADJ
fnp-2671	434	24	1	1	NUM
fnp-2671	434	25	updates	update	NOUN
fnp-2671	434	26	.	.	PUNCT
fnp-2671	435	1	brain	brain	NOUN
fnp-2671	435	2	pathol	pathol	NOUN
fnp-2671	435	3	,	,	PUNCT
fnp-2671	435	4	2019	2019	NUM
fnp-2671	435	5	.	.	PUNCT
fnp-2671	436	1	29(4	29(4	NOUN
fnp-2671	436	2	):	):	PUNCT
fnp-2671	437	1	p.	p.	NOUN
fnp-2671	437	2	469	469	NUM
fnp-2671	437	3	-	-	PROPN
fnp-2671	437	4	472	472	NUM
fnp-2671	437	5	.	.	PUNCT
fnp-2671	438	1	56	56	NUM
fnp-2671	438	2	.	.	PUNCT
fnp-2671	438	3	hodges	hodges	PROPN
fnp-2671	438	4	,	,	PUNCT
fnp-2671	438	5	t.r	t.r	PROPN
fnp-2671	438	6	.	.	PROPN
fnp-2671	438	7	,	,	PUNCT
fnp-2671	438	8	et	et	PROPN
fnp-2671	438	9	al	al	PROPN
fnp-2671	438	10	.	.	PROPN
fnp-2671	438	11	,	,	PUNCT
fnp-2671	438	12	mutational	mutational	ADJ
fnp-2671	438	13	burden	burden	NOUN
fnp-2671	438	14	,	,	PUNCT
fnp-2671	438	15	immune	immune	ADJ
fnp-2671	438	16	checkpoint	checkpoint	NOUN
fnp-2671	438	17	expression	expression	NOUN
fnp-2671	438	18	,	,	PUNCT
fnp-2671	438	19	and	and	CCONJ
fnp-2671	438	20	mismatch	mismatch	ADJ
fnp-2671	438	21	repair	repair	NOUN
fnp-2671	438	22	in	in	ADP
fnp-2671	438	23	glioma	glioma	NOUN
fnp-2671	438	24	:	:	PUNCT
fnp-2671	438	25	implications	implication	NOUN
fnp-2671	438	26	for	for	ADP
fnp-2671	438	27	immune	immune	ADJ
fnp-2671	438	28	checkpoint	checkpoint	NOUN
fnp-2671	438	29	immunotherapy	immunotherapy	NOUN
fnp-2671	438	30	.	.	PUNCT
fnp-2671	439	1	neuro	neuro	PROPN
fnp-2671	439	2	oncol	oncol	PROPN
fnp-2671	439	3	,	,	PUNCT
fnp-2671	439	4	2017	2017	NUM
fnp-2671	439	5	.	.	PUNCT
fnp-2671	440	1	19(8	19(8	NUM
fnp-2671	440	2	):	):	PUNCT
fnp-2671	440	3	p.	p.	NOUN
fnp-2671	440	4	1047	1047	NUM
fnp-2671	440	5	-	-	SYM
fnp-2671	440	6	1057	1057	NUM
fnp-2671	440	7	.	.	PUNCT
fnp-2671	441	1	57	57	NUM
fnp-2671	441	2	.	.	X
fnp-2671	442	1	tan	tan	PROPN
fnp-2671	442	2	,	,	PUNCT
fnp-2671	442	3	a.c	a.c	PROPN
fnp-2671	442	4	.	.	PROPN
fnp-2671	442	5	,	,	PUNCT
fnp-2671	442	6	a.b	a.b	PROPN
fnp-2671	442	7	.	.	NOUN
fnp-2671	442	8	heimberger	heimberger	NOUN
fnp-2671	442	9	,	,	PUNCT
fnp-2671	442	10	and	and	CCONJ
fnp-2671	442	11	m.	m.	PROPN
fnp-2671	442	12	khasraw	khasraw	PROPN
fnp-2671	442	13	,	,	PUNCT
fnp-2671	442	14	immune	immune	ADJ
fnp-2671	442	15	checkpoint	checkpoint	NOUN
fnp-2671	442	16	inhibitors	inhibitor	NOUN
fnp-2671	442	17	in	in	ADP
fnp-2671	442	18	gliomas	glioma	NOUN
fnp-2671	442	19	.	.	PUNCT
fnp-2671	443	1	curr	curr	PROPN
fnp-2671	443	2	oncol	oncol	PROPN
fnp-2671	443	3	rep	rep	PROPN
fnp-2671	443	4	,	,	PUNCT
fnp-2671	443	5	2017	2017	NUM
fnp-2671	443	6	.	.	PUNCT
fnp-2671	444	1	19(4	19(4	NUM
fnp-2671	444	2	):	):	PUNCT
fnp-2671	444	3	p.	p.	NOUN
fnp-2671	444	4	23	23	NUM
fnp-2671	444	5	.	.	PUNCT
fnp-2671	445	1	58	58	NUM
fnp-2671	445	2	.	.	PUNCT
fnp-2671	446	1	mckinney	mckinney	PROPN
fnp-2671	446	2	,	,	PUNCT
fnp-2671	446	3	s.m	s.m	PROPN
fnp-2671	446	4	.	.	PROPN
fnp-2671	446	5	,	,	PUNCT
fnp-2671	446	6	et	et	PROPN
fnp-2671	446	7	al	al	PROPN
fnp-2671	446	8	.	.	PROPN
fnp-2671	446	9	,	,	PUNCT
fnp-2671	446	10	international	international	ADJ
fnp-2671	446	11	evaluation	evaluation	NOUN
fnp-2671	446	12	of	of	ADP
fnp-2671	446	13	an	an	DET
fnp-2671	446	14	ai	ai	NOUN
fnp-2671	446	15	system	system	NOUN
fnp-2671	446	16	for	for	ADP
fnp-2671	446	17	breast	breast	NOUN
fnp-2671	446	18	cancer	cancer	NOUN
fnp-2671	446	19	screening	screening	NOUN
fnp-2671	446	20	.	.	PUNCT
fnp-2671	447	1	nature	nature	NOUN
fnp-2671	447	2	,	,	PUNCT
fnp-2671	447	3	2020	2020	NUM
fnp-2671	447	4	.	.	PUNCT
fnp-2671	448	1	577(7788	577(7788	NUM
fnp-2671	448	2	):	):	PUNCT
fnp-2671	448	3	p.	p.	NOUN
fnp-2671	448	4	89	89	NUM
fnp-2671	448	5	-	-	SYM
fnp-2671	448	6	94	94	NUM
fnp-2671	448	7	.	.	PUNCT
fnp-2671	449	1	59	59	NUM
fnp-2671	449	2	.	.	PUNCT
fnp-2671	449	3	ker	ker	PROPN
fnp-2671	449	4	,	,	PUNCT
fnp-2671	449	5	j.	j.	PROPN
fnp-2671	449	6	,	,	PUNCT
fnp-2671	449	7	et	et	PROPN
fnp-2671	449	8	al	al	PROPN
fnp-2671	449	9	.	.	PROPN
fnp-2671	449	10	,	,	PUNCT
fnp-2671	449	11	automated	automate	VERB
fnp-2671	449	12	brain	brain	NOUN
fnp-2671	449	13	histology	histology	NOUN
fnp-2671	449	14	classification	classification	NOUN
fnp-2671	449	15	using	use	VERB
fnp-2671	449	16	machine	machine	NOUN
fnp-2671	449	17	learning	learning	NOUN
fnp-2671	449	18	.	.	PUNCT
fnp-2671	450	1	j	j	PROPN
fnp-2671	450	2	clin	clin	PROPN
fnp-2671	450	3	neurosci	neurosci	PROPN
fnp-2671	450	4	,	,	PUNCT
fnp-2671	450	5	2019	2019	NUM
fnp-2671	450	6	.	.	PUNCT
fnp-2671	451	1	66	66	NUM
fnp-2671	451	2	:	:	PUNCT
fnp-2671	451	3	p.	p.	NOUN
fnp-2671	451	4	239	239	NUM
fnp-2671	451	5	-	-	SYM
fnp-2671	451	6	245	245	NUM
fnp-2671	451	7	.	.	PUNCT
fnp-2671	451	8	60	60	NUM
fnp-2671	451	9	.	.	PUNCT
fnp-2671	452	1	korfiatis	korfiatis	NOUN
fnp-2671	452	2	,	,	PUNCT
fnp-2671	452	3	p.	p.	NOUN
fnp-2671	452	4	and	and	CCONJ
fnp-2671	452	5	b.	b.	PROPN
fnp-2671	452	6	erickson	erickson	PROPN
fnp-2671	452	7	,	,	PUNCT
fnp-2671	452	8	deep	deep	ADJ
fnp-2671	452	9	learning	learning	NOUN
fnp-2671	452	10	can	can	AUX
fnp-2671	452	11	see	see	VERB
fnp-2671	452	12	the	the	DET
fnp-2671	452	13	unseeable	unseeable	ADJ
fnp-2671	452	14	:	:	PUNCT
fnp-2671	452	15	predicting	predict	VERB
fnp-2671	452	16	molecular	molecular	ADJ
fnp-2671	452	17	markers	marker	NOUN
fnp-2671	452	18	from	from	ADP
fnp-2671	452	19	mri	mri	NOUN
fnp-2671	452	20	of	of	ADP
fnp-2671	452	21	brain	brain	NOUN
fnp-2671	452	22	gliomas	glioma	NOUN
fnp-2671	452	23	.	.	PUNCT
fnp-2671	453	1	clin	clin	PROPN
fnp-2671	453	2	radiol	radiol	PROPN
fnp-2671	453	3	,	,	PUNCT
fnp-2671	453	4	2019	2019	NUM
fnp-2671	453	5	.	.	PUNCT
fnp-2671	454	1	74(5	74(5	NUM
fnp-2671	454	2	):	):	PUNCT
fnp-2671	455	1	p.	p.	NOUN
fnp-2671	455	2	367	367	NUM
fnp-2671	455	3	-	-	SYM
fnp-2671	455	4	373	373	NUM
fnp-2671	455	5	.	.	PUNCT
fnp-2671	455	6	61	61	NUM
fnp-2671	455	7	.	.	PUNCT
fnp-2671	456	1	gritsenko	gritsenko	PROPN
fnp-2671	456	2	,	,	PUNCT
fnp-2671	456	3	p.g	p.g	PROPN
fnp-2671	456	4	.	.	PROPN
fnp-2671	456	5	,	,	PUNCT
fnp-2671	456	6	et	et	PROPN
fnp-2671	456	7	al	al	PROPN
fnp-2671	456	8	.	.	PROPN
fnp-2671	456	9	,	,	PUNCT
fnp-2671	456	10	p120	p120	PROPN
fnp-2671	456	11	-	-	PUNCT
fnp-2671	456	12	catenin	catenin	NOUN
fnp-2671	456	13	-	-	PUNCT
fnp-2671	456	14	dependent	dependent	ADJ
fnp-2671	456	15	collective	collective	ADJ
fnp-2671	456	16	brain	brain	NOUN
fnp-2671	456	17	infiltration	infiltration	NOUN
fnp-2671	456	18	by	by	ADP
fnp-2671	456	19	glioma	glioma	NOUN
fnp-2671	456	20	cell	cell	NOUN
fnp-2671	456	21	networks	network	NOUN
fnp-2671	456	22	.	.	PUNCT
fnp-2671	457	1	nat	nat	NOUN
fnp-2671	457	2	cell	cell	NOUN
fnp-2671	457	3	biol	biol	PROPN
fnp-2671	457	4	,	,	PUNCT
fnp-2671	457	5	2020	2020	NUM
fnp-2671	457	6	.	.	PUNCT
fnp-2671	458	1	22(1	22(1	NUM
fnp-2671	458	2	):	):	PUNCT
fnp-2671	458	3	p.	p.	NOUN
fnp-2671	458	4	97	97	NUM
fnp-2671	458	5	-	-	SYM
fnp-2671	458	6	107	107	NUM
fnp-2671	458	7	.	.	PUNCT
fnp-2671	459	1	copyright	copyright	NOUN
fnp-2671	459	2	:	:	PUNCT
fnp-2671	459	3	©	©	PROPN
fnp-2671	459	4	2020	2020	NUM
fnp-2671	459	5	the	the	DET
fnp-2671	459	6	author(s	author(s	NOUN
fnp-2671	459	7	)	)	PUNCT
fnp-2671	459	8	.	.	PUNCT
fnp-2671	460	1	this	this	PRON
fnp-2671	460	2	is	be	AUX
fnp-2671	460	3	an	an	DET
fnp-2671	460	4	open	open	ADJ
fnp-2671	460	5	access	access	NOUN
fnp-2671	460	6	article	article	NOUN
fnp-2671	460	7	distributed	distribute	VERB
fnp-2671	460	8	under	under	ADP
fnp-2671	460	9	the	the	DET
fnp-2671	460	10	terms	term	NOUN
fnp-2671	460	11	of	of	ADP
fnp-2671	460	12	the	the	DET
fnp-2671	460	13	creative	creative	ADJ
fnp-2671	460	14	commons	common	NOUN
fnp-2671	460	15	attribution	attribution	NOUN
fnp-2671	460	16	4.0	4.0	NUM
fnp-2671	460	17	international	international	ADJ
fnp-2671	460	18	license	license	NOUN
fnp-2671	460	19	(	(	PUNCT
fnp-2671	460	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-2671	460	21	)	)	PUNCT
fnp-2671	460	22	,	,	PUNCT
fnp-2671	460	23	which	which	PRON
fnp-2671	460	24	permits	permit	VERB
fnp-2671	460	25	unrestricted	unrestricted	ADJ
fnp-2671	460	26	use	use	NOUN
fnp-2671	460	27	,	,	PUNCT
fnp-2671	460	28	distribution	distribution	NOUN
fnp-2671	460	29	,	,	PUNCT
fnp-2671	460	30	and	and	CCONJ
fnp-2671	460	31	reproduction	reproduction	NOUN
fnp-2671	460	32	in	in	ADP
fnp-2671	460	33	any	any	DET
fnp-2671	460	34	medium	medium	NOUN
fnp-2671	460	35	,	,	PUNCT
fnp-2671	460	36	provided	provide	VERB
fnp-2671	460	37	the	the	DET
fnp-2671	460	38	original	original	ADJ
fnp-2671	460	39	author	author	NOUN
fnp-2671	460	40	and	and	CCONJ
fnp-2671	460	41	source	source	NOUN
fnp-2671	460	42	are	be	AUX
fnp-2671	460	43	credited	credit	VERB
fnp-2671	460	44	,	,	PUNCT
fnp-2671	460	45	a	a	DET
fnp-2671	460	46	link	link	NOUN
fnp-2671	460	47	to	to	ADP
fnp-2671	460	48	the	the	DET
fnp-2671	460	49	creative	creative	ADJ
fnp-2671	460	50	commons	common	NOUN
fnp-2671	460	51	license	license	NOUN
fnp-2671	460	52	is	be	AUX
fnp-2671	460	53	provided	provide	VERB
fnp-2671	460	54	,	,	PUNCT
fnp-2671	460	55	and	and	CCONJ
fnp-2671	460	56	any	any	DET
fnp-2671	460	57	changes	change	NOUN
fnp-2671	460	58	are	be	AUX
fnp-2671	460	59	indicated	indicate	VERB
fnp-2671	460	60	.	.	PUNCT
fnp-2671	461	1	the	the	DET
fnp-2671	461	2	creative	creative	ADJ
fnp-2671	461	3	commons	common	NOUN
fnp-2671	461	4	public	public	ADJ
fnp-2671	461	5	domain	domain	NOUN
fnp-2671	461	6	dedication	dedication	NOUN
fnp-2671	461	7	waiver	waiver	NOUN
fnp-2671	461	8	(	(	PUNCT
fnp-2671	461	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-2671	461	10	)	)	PUNCT
fnp-2671	461	11	applies	apply	VERB
fnp-2671	461	12	to	to	ADP
fnp-2671	461	13	the	the	DET
fnp-2671	461	14	data	datum	NOUN
fnp-2671	461	15	made	make	VERB
fnp-2671	461	16	available	available	ADJ
fnp-2671	461	17	in	in	ADP
fnp-2671	461	18	this	this	DET
fnp-2671	461	19	article	article	NOUN
fnp-2671	461	20	,	,	PUNCT
fnp-2671	461	21	unless	unless	SCONJ
fnp-2671	461	22	otherwise	otherwise	ADV
fnp-2671	461	23	stated	state	VERB
fnp-2671	461	24	.	.	PUNCT