id	sid	tid	token	lemma	pos
fnp-2911	1	1	neuronal	neuronal	ADJ
fnp-2911	1	2	transcriptome	transcriptome	NOUN
fnp-2911	1	3	from	from	ADP
fnp-2911	1	4	c9orf72	c9orf72	PROPN
fnp-2911	1	5	repeat	repeat	PROPN
fnp-2911	1	6	expanded	expand	VERB
fnp-2911	1	7	human	human	ADJ
fnp-2911	1	8	tissue	tissue	NOUN
fnp-2911	1	9	is	be	AUX
fnp-2911	1	10	associated	associate	VERB
fnp-2911	1	11	with	with	ADP
fnp-2911	1	12	loss	loss	NOUN
fnp-2911	1	13	of	of	ADP
fnp-2911	1	14	c9orf72	c9orf72	ADJ
fnp-2911	1	15	function	function	NOUN
fnp-2911	1	16	feel	feel	VERB
fnp-2911	1	17	free	free	ADJ
fnp-2911	1	18	to	to	PART
fnp-2911	1	19	add	add	VERB
fnp-2911	1	20	comments	comment	NOUN
fnp-2911	1	21	by	by	ADP
fnp-2911	1	22	clicking	click	VERB
fnp-2911	1	23	these	these	DET
fnp-2911	1	24	icons	icon	NOUN
fnp-2911	1	25	on	on	ADP
fnp-2911	1	26	the	the	DET
fnp-2911	1	27	sidebar	sidebar	NOUN
fnp-2911	1	28	free	free	ADJ
fnp-2911	1	29	neuropathology	neuropathology	NOUN
fnp-2911	1	30	1:23	1:23	NUM
fnp-2911	1	31	(	(	PUNCT
fnp-2911	1	32	2020	2020	NUM
fnp-2911	1	33	)	)	PUNCT
fnp-2911	1	34	original	original	ADJ
fnp-2911	1	35	paper	paper	NOUN
fnp-2911	1	36	neuronal	neuronal	ADJ
fnp-2911	1	37	transcriptome	transcriptome	NOUN
fnp-2911	1	38	from	from	ADP
fnp-2911	1	39	c9orf72	c9orf72	PROPN
fnp-2911	1	40	repeat	repeat	PROPN
fnp-2911	1	41	expanded	expand	VERB
fnp-2911	1	42	human	human	ADJ
fnp-2911	1	43	tissue	tissue	NOUN
fnp-2911	1	44	is	be	AUX
fnp-2911	1	45	associated	associate	VERB
fnp-2911	1	46	with	with	ADP
fnp-2911	1	47	loss	loss	NOUN
fnp-2911	1	48	of	of	ADP
fnp-2911	1	49	c9orf72	c9orf72	PROPN
fnp-2911	1	50	function	function	PROPN
fnp-2911	1	51	elaine	elaine	PROPN
fnp-2911	1	52	y.	y.	PROPN
fnp-2911	1	53	liu1	liu1	PROPN
fnp-2911	1	54	,	,	PUNCT
fnp-2911	1	55	jenny	jenny	PROPN
fnp-2911	1	56	russ1	russ1	PROPN
fnp-2911	1	57	,	,	PUNCT
fnp-2911	1	58	edward	edward	PROPN
fnp-2911	1	59	b.	b.	PROPN
fnp-2911	2	1	lee1	lee1	PROPN
fnp-2911	2	2	1	1	NUM
fnp-2911	2	3	translational	translational	ADJ
fnp-2911	2	4	neuropathology	neuropathology	NOUN
fnp-2911	2	5	research	research	NOUN
fnp-2911	2	6	laboratory	laboratory	NOUN
fnp-2911	2	7	,	,	PUNCT
fnp-2911	2	8	university	university	PROPN
fnp-2911	2	9	of	of	ADP
fnp-2911	2	10	pennsylvania	pennsylvania	PROPN
fnp-2911	2	11	,	,	PUNCT
fnp-2911	2	12	philadelphia	philadelphia	PROPN
fnp-2911	2	13	,	,	PUNCT
fnp-2911	2	14	pa	pa	PROPN
fnp-2911	2	15	,	,	PUNCT
fnp-2911	2	16	usa	usa	PROPN
fnp-2911	2	17	corresponding	corresponding	PROPN
fnp-2911	2	18	author	author	NOUN
fnp-2911	2	19	:	:	PUNCT
fnp-2911	2	20	edward	edward	PROPN
fnp-2911	2	21	b.	b.	PROPN
fnp-2911	2	22	lee	lee	PROPN
fnp-2911	2	23	,	,	PUNCT
fnp-2911	2	24	m.d	m.d	PROPN
fnp-2911	2	25	.	.	PROPN
fnp-2911	2	26	,	,	PUNCT
fnp-2911	2	27	ph.d	ph.d	PROPN
fnp-2911	2	28	.	.	PUNCT
fnp-2911	2	29	·	·	PUNCT
fnp-2911	3	1	613a	613a	NUM
fnp-2911	3	2	stellar	stellar	ADJ
fnp-2911	3	3	chance	chance	NOUN
fnp-2911	3	4	laboratories	laboratory	NOUN
fnp-2911	3	5	·	·	PUNCT
fnp-2911	3	6	422	422	NUM
fnp-2911	3	7	curie	curie	NOUN
fnp-2911	3	8	blvd	blvd	PROPN
fnp-2911	3	9	·	·	PUNCT
fnp-2911	3	10	philadelphia	philadelphia	PROPN
fnp-2911	3	11	,	,	PUNCT
fnp-2911	3	12	pa	pa	PROPN
fnp-2911	3	13	9104	9104	NUM
fnp-2911	3	14	·	·	PUNCT
fnp-2911	3	15	usa	usa	PROPN
fnp-2911	3	16	·	·	PUNCT
fnp-2911	3	17	001	001	NUM
fnp-2911	3	18	(	(	PUNCT
fnp-2911	3	19	215	215	NUM
fnp-2911	3	20	)	)	SYM
fnp-2911	3	21	898	898	NUM
fnp-2911	3	22	-	-	SYM
fnp-2911	3	23	0908	0908	NUM
fnp-2911	3	24	edward.lee@pennmedicine.upenn.edu	edward.lee@pennmedicine.upenn.edu	VERB
fnp-2911	3	25	submitted	submit	VERB
fnp-2911	3	26	:	:	PUNCT
fnp-2911	3	27	20	20	NUM
fnp-2911	3	28	july	july	PROPN
fnp-2911	3	29	2020	2020	NUM
fnp-2911	3	30	accepted	accept	VERB
fnp-2911	3	31	:	:	PUNCT
fnp-2911	3	32	13	13	NUM
fnp-2911	3	33	august	august	PROPN
fnp-2911	3	34	2020	2020	NUM
fnp-2911	3	35	copyedited	copyedit	VERB
fnp-2911	3	36	by	by	ADP
fnp-2911	3	37	:	:	PUNCT
fnp-2911	3	38	lauren	lauren	PROPN
fnp-2911	3	39	walker	walker	PROPN
fnp-2911	3	40	published	publish	VERB
fnp-2911	3	41	:	:	PUNCT
fnp-2911	4	1	21	21	NUM
fnp-2911	4	2	august	august	PROPN
fnp-2911	4	3	2020	2020	NUM
fnp-2911	4	4	https://doi.org/10.17879/freeneuropathology-2020-2911	https://doi.org/10.17879/freeneuropathology-2020-2911	ADP
fnp-2911	4	5	additional	additional	ADJ
fnp-2911	4	6	resources	resource	NOUN
fnp-2911	4	7	and	and	CCONJ
fnp-2911	4	8	electronic	electronic	ADJ
fnp-2911	4	9	supplementary	supplementary	ADJ
fnp-2911	4	10	material	material	NOUN
fnp-2911	4	11	:	:	PUNCT
fnp-2911	4	12	supplementary	supplementary	ADJ
fnp-2911	4	13	material	material	NOUN
fnp-2911	4	14	keywords	keyword	NOUN
fnp-2911	4	15	:	:	PUNCT
fnp-2911	4	16	dementia	dementia	NOUN
fnp-2911	4	17	,	,	PUNCT
fnp-2911	4	18	transcriptome	transcriptome	NOUN
fnp-2911	4	19	,	,	PUNCT
fnp-2911	4	20	frontotemporal	frontotemporal	ADJ
fnp-2911	4	21	,	,	PUNCT
fnp-2911	4	22	amyotrophic	amyotrophic	ADJ
fnp-2911	4	23	lateral	lateral	ADJ
fnp-2911	4	24	sclerosis	sclerosis	NOUN
fnp-2911	4	25	,	,	PUNCT
fnp-2911	4	26	c9orf72	c9orf72	PROPN
fnp-2911	4	27	,	,	PUNCT
fnp-2911	4	28	tdp-43	tdp-43	PROPN
fnp-2911	4	29	,	,	PUNCT
fnp-2911	4	30	facs	fac	NOUN
fnp-2911	4	31	,	,	PUNCT
fnp-2911	4	32	rna	rna	NOUN
fnp-2911	4	33	-	-	PUNCT
fnp-2911	4	34	seq	seq	NOUN
fnp-2911	4	35	,	,	PUNCT
fnp-2911	4	36	repeat	repeat	NOUN
fnp-2911	4	37	expansion	expansion	NOUN
fnp-2911	4	38	,	,	PUNCT
fnp-2911	4	39	denn	denn	NOUN
fnp-2911	4	40	,	,	PUNCT
fnp-2911	4	41	frontotemporal	frontotemporal	ADJ
fnp-2911	4	42	lobar	lobar	ADJ
fnp-2911	4	43	degeneration	degeneration	NOUN
fnp-2911	4	44	,	,	PUNCT
fnp-2911	4	45	frontotemporal	frontotemporal	ADJ
fnp-2911	4	46	dementia	dementia	NOUN
fnp-2911	4	47	abstract	abstract	ADJ
fnp-2911	4	48	a	a	DET
fnp-2911	4	49	hexanucleotide	hexanucleotide	NOUN
fnp-2911	4	50	g4c2	g4c2	VERB
fnp-2911	4	51	repeat	repeat	NOUN
fnp-2911	4	52	expansion	expansion	NOUN
fnp-2911	4	53	in	in	ADP
fnp-2911	4	54	c9orf72	c9orf72	PROPN
fnp-2911	4	55	is	be	AUX
fnp-2911	4	56	the	the	DET
fnp-2911	4	57	most	most	ADV
fnp-2911	4	58	common	common	ADJ
fnp-2911	4	59	genetic	genetic	ADJ
fnp-2911	4	60	cause	cause	NOUN
fnp-2911	4	61	of	of	ADP
fnp-2911	4	62	familial	familial	ADJ
fnp-2911	4	63	and	and	CCONJ
fnp-2911	4	64	sporadic	sporadic	ADJ
fnp-2911	4	65	cases	case	NOUN
fnp-2911	4	66	of	of	ADP
fnp-2911	4	67	amyotrophic	amyotrophic	ADJ
fnp-2911	4	68	lateral	lateral	ADJ
fnp-2911	4	69	sclerosis	sclerosis	NOUN
fnp-2911	4	70	(	(	PUNCT
fnp-2911	4	71	als	als	NOUN
fnp-2911	4	72	)	)	PUNCT
fnp-2911	4	73	and	and	CCONJ
fnp-2911	4	74	frontotemporal	frontotemporal	ADJ
fnp-2911	4	75	degeneration	degeneration	NOUN
fnp-2911	4	76	(	(	PUNCT
fnp-2911	4	77	ftd	ftd	NOUN
fnp-2911	4	78	)	)	PUNCT
fnp-2911	4	79	.	.	PUNCT
fnp-2911	5	1	the	the	DET
fnp-2911	5	2	mutation	mutation	NOUN
fnp-2911	5	3	is	be	AUX
fnp-2911	5	4	associated	associate	VERB
fnp-2911	5	5	with	with	ADP
fnp-2911	5	6	a	a	DET
fnp-2911	5	7	reduction	reduction	NOUN
fnp-2911	5	8	of	of	ADP
fnp-2911	5	9	c9orf72	c9orf72	ADJ
fnp-2911	5	10	protein	protein	NOUN
fnp-2911	5	11	and	and	CCONJ
fnp-2911	5	12	accumulation	accumulation	NOUN
fnp-2911	5	13	of	of	ADP
fnp-2911	5	14	toxic	toxic	ADJ
fnp-2911	5	15	rna	rna	NOUN
fnp-2911	5	16	and	and	CCONJ
fnp-2911	5	17	dipeptide	dipeptide	NOUN
fnp-2911	5	18	repeat	repeat	NOUN
fnp-2911	5	19	aggregates	aggregate	NOUN
fnp-2911	5	20	.	.	PUNCT
fnp-2911	6	1	the	the	DET
fnp-2911	6	2	accumulation	accumulation	NOUN
fnp-2911	6	3	of	of	ADP
fnp-2911	6	4	toxic	toxic	ADJ
fnp-2911	6	5	rna	rna	PROPN
fnp-2911	6	6	has	have	AUX
fnp-2911	6	7	been	be	AUX
fnp-2911	6	8	proposed	propose	VERB
fnp-2911	6	9	to	to	PART
fnp-2911	6	10	sequester	sequester	VERB
fnp-2911	6	11	rna	rna	NOUN
fnp-2911	6	12	binding	bind	VERB
fnp-2911	6	13	proteins	protein	NOUN
fnp-2911	6	14	thereby	thereby	ADV
fnp-2911	6	15	altering	alter	VERB
fnp-2911	6	16	rna	rna	NOUN
fnp-2911	6	17	processing	processing	NOUN
fnp-2911	6	18	,	,	PUNCT
fnp-2911	6	19	consistent	consistent	ADJ
fnp-2911	6	20	with	with	ADP
fnp-2911	6	21	previous	previous	ADJ
fnp-2911	6	22	transcriptome	transcriptome	ADJ
fnp-2911	6	23	studies	study	NOUN
fnp-2911	6	24	that	that	PRON
fnp-2911	6	25	have	have	AUX
fnp-2911	6	26	shown	show	VERB
fnp-2911	6	27	that	that	SCONJ
fnp-2911	6	28	the	the	DET
fnp-2911	6	29	c9orf72	c9orf72	PROPN
fnp-2911	6	30	repeat	repeat	NOUN
fnp-2911	6	31	expansion	expansion	NOUN
fnp-2911	6	32	is	be	AUX
fnp-2911	6	33	linked	link	VERB
fnp-2911	6	34	to	to	ADP
fnp-2911	6	35	abundant	abundant	ADJ
fnp-2911	6	36	splicing	splicing	NOUN
fnp-2911	6	37	alterations	alteration	NOUN
fnp-2911	6	38	and	and	CCONJ
fnp-2911	6	39	transcriptome	transcriptome	ADJ
fnp-2911	6	40	changes	change	NOUN
fnp-2911	6	41	.	.	PUNCT
fnp-2911	7	1	here	here	ADV
fnp-2911	7	2	,	,	PUNCT
fnp-2911	7	3	we	we	PRON
fnp-2911	7	4	used	use	VERB
fnp-2911	7	5	a	a	DET
fnp-2911	7	6	subcellular	subcellular	ADJ
fnp-2911	7	7	fractionation	fractionation	NOUN
fnp-2911	7	8	method	method	NOUN
fnp-2911	7	9	and	and	CCONJ
fnp-2911	7	10	facs	fac	NOUN
fnp-2911	7	11	to	to	PART
fnp-2911	7	12	enrich	enrich	VERB
fnp-2911	7	13	for	for	ADP
fnp-2911	7	14	neuronal	neuronal	ADJ
fnp-2911	7	15	nuclei	nucleus	NOUN
fnp-2911	7	16	from	from	ADP
fnp-2911	7	17	c9orf72	c9orf72	PROPN
fnp-2911	7	18	repeat	repeat	PROPN
fnp-2911	7	19	expanded	expand	VERB
fnp-2911	7	20	post	post	ADJ
fnp-2911	7	21	-	-	ADJ
fnp-2911	7	22	mortem	mortem	ADJ
fnp-2911	7	23	human	human	ADJ
fnp-2911	7	24	als	al	NOUN
fnp-2911	7	25	/	/	SYM
fnp-2911	7	26	ftd	ftd	NOUN
fnp-2911	7	27	brains	brain	NOUN
fnp-2911	7	28	,	,	PUNCT
fnp-2911	7	29	and	and	CCONJ
fnp-2911	7	30	to	to	PART
fnp-2911	7	31	remove	remove	VERB
fnp-2911	7	32	neuronal	neuronal	ADJ
fnp-2911	7	33	nuclei	nucleus	NOUN
fnp-2911	7	34	with	with	ADP
fnp-2911	7	35	tdp-43	tdp-43	PROPN
fnp-2911	7	36	pathology	pathology	NOUN
fnp-2911	7	37	which	which	PRON
fnp-2911	7	38	are	be	AUX
fnp-2911	7	39	observed	observe	VERB
fnp-2911	7	40	in	in	ADP
fnp-2911	7	41	nearly	nearly	ADV
fnp-2911	7	42	all	all	PRON
fnp-2911	7	43	symptomatic	symptomatic	ADJ
fnp-2911	7	44	c9orf72	c9orf72	NOUN
fnp-2911	7	45	repeat	repeat	PROPN
fnp-2911	7	46	expanded	expand	VERB
fnp-2911	7	47	cases	case	NOUN
fnp-2911	7	48	.	.	PUNCT
fnp-2911	8	1	we	we	PRON
fnp-2911	8	2	show	show	VERB
fnp-2911	8	3	that	that	SCONJ
fnp-2911	8	4	the	the	DET
fnp-2911	8	5	c9orf72	c9orf72	ADJ
fnp-2911	8	6	expansion	expansion	NOUN
fnp-2911	8	7	is	be	AUX
fnp-2911	8	8	associated	associate	VERB
fnp-2911	8	9	with	with	ADP
fnp-2911	8	10	relatively	relatively	ADV
fnp-2911	8	11	mild	mild	ADJ
fnp-2911	8	12	gene	gene	NOUN
fnp-2911	8	13	expression	expression	NOUN
fnp-2911	8	14	changes	change	NOUN
fnp-2911	8	15	.	.	PUNCT
fnp-2911	9	1	dysregulated	dysregulated	ADJ
fnp-2911	9	2	genes	gene	NOUN
fnp-2911	9	3	were	be	AUX
fnp-2911	9	4	enriched	enrich	VERB
fnp-2911	9	5	for	for	ADP
fnp-2911	9	6	vesicle	vesicle	NOUN
fnp-2911	9	7	transport	transport	NOUN
fnp-2911	9	8	pathways	pathway	NOUN
fnp-2911	9	9	,	,	PUNCT
fnp-2911	9	10	which	which	PRON
fnp-2911	9	11	is	be	AUX
fnp-2911	9	12	consistent	consistent	ADJ
fnp-2911	9	13	with	with	ADP
fnp-2911	9	14	the	the	DET
fnp-2911	9	15	known	know	VERB
fnp-2911	9	16	functions	function	NOUN
fnp-2911	9	17	of	of	ADP
fnp-2911	9	18	c9orf72	c9orf72	ADJ
fnp-2911	9	19	protein	protein	NOUN
fnp-2911	9	20	.	.	PUNCT
fnp-2911	10	1	further	further	ADJ
fnp-2911	10	2	analysis	analysis	NOUN
fnp-2911	10	3	suggests	suggest	VERB
fnp-2911	10	4	that	that	SCONJ
fnp-2911	10	5	the	the	DET
fnp-2911	10	6	c9orf72	c9orf72	PROPN
fnp-2911	10	7	transcriptome	transcriptome	NOUN
fnp-2911	10	8	is	be	AUX
fnp-2911	10	9	not	not	PART
fnp-2911	10	10	driven	drive	VERB
fnp-2911	10	11	by	by	ADP
fnp-2911	10	12	toxic	toxic	ADJ
fnp-2911	10	13	rna	rna	PROPN
fnp-2911	10	14	but	but	CCONJ
fnp-2911	10	15	is	be	AUX
fnp-2911	10	16	rather	rather	ADV
fnp-2911	10	17	shaped	shape	VERB
fnp-2911	10	18	by	by	ADP
fnp-2911	10	19	the	the	DET
fnp-2911	10	20	depletion	depletion	NOUN
fnp-2911	10	21	of	of	ADP
fnp-2911	10	22	pathologic	pathologic	ADJ
fnp-2911	10	23	tdp-43	tdp-43	NOUN
fnp-2911	10	24	nuclei	nucleus	NOUN
fnp-2911	10	25	and	and	CCONJ
fnp-2911	10	26	the	the	DET
fnp-2911	10	27	loss	loss	NOUN
fnp-2911	10	28	of	of	ADP
fnp-2911	10	29	c9orf72	c9orf72	ADJ
fnp-2911	10	30	expression	expression	NOUN
fnp-2911	10	31	.	.	PUNCT
fnp-2911	11	1	these	these	DET
fnp-2911	11	2	findings	finding	NOUN
fnp-2911	11	3	argue	argue	VERB
fnp-2911	11	4	against	against	ADP
fnp-2911	11	5	rna	rna	NOUN
fnp-2911	11	6	binding	bind	VERB
fnp-2911	11	7	protein	protein	NOUN
fnp-2911	11	8	sequestration	sequestration	NOUN
fnp-2911	11	9	in	in	ADP
fnp-2911	11	10	neurons	neuron	NOUN
fnp-2911	11	11	as	as	ADP
fnp-2911	11	12	a	a	DET
fnp-2911	11	13	major	major	ADJ
fnp-2911	11	14	contributor	contributor	NOUN
fnp-2911	11	15	to	to	ADP
fnp-2911	11	16	c9orf72	c9orf72	ADJ
fnp-2911	11	17	mediated	mediate	VERB
fnp-2911	11	18	toxicity	toxicity	NOUN
fnp-2911	11	19	.	.	PUNCT
fnp-2911	12	1	introduction	introduction	NOUN
fnp-2911	12	2	amyotrophic	amyotrophic	ADJ
fnp-2911	12	3	lateral	lateral	ADJ
fnp-2911	12	4	sclerosis	sclerosis	NOUN
fnp-2911	12	5	(	(	PUNCT
fnp-2911	12	6	als	als	NOUN
fnp-2911	12	7	)	)	PUNCT
fnp-2911	12	8	and	and	CCONJ
fnp-2911	12	9	frontotemporal	frontotemporal	ADJ
fnp-2911	12	10	degeneration	degeneration	NOUN
fnp-2911	12	11	(	(	PUNCT
fnp-2911	12	12	ftd	ftd	NOUN
fnp-2911	12	13	)	)	PUNCT
fnp-2911	12	14	are	be	AUX
fnp-2911	12	15	fatal	fatal	ADJ
fnp-2911	12	16	neurodegenerative	neurodegenerative	ADJ
fnp-2911	12	17	diseases	disease	NOUN
fnp-2911	12	18	with	with	ADP
fnp-2911	12	19	overlapping	overlap	VERB
fnp-2911	12	20	clinical	clinical	ADJ
fnp-2911	12	21	,	,	PUNCT
fnp-2911	12	22	pathologic	pathologic	ADJ
fnp-2911	12	23	and	and	CCONJ
fnp-2911	12	24	genetic	genetic	ADJ
fnp-2911	12	25	features	feature	NOUN
fnp-2911	12	26	.	.	PUNCT
fnp-2911	13	1	als	als	NOUN
fnp-2911	13	2	is	be	AUX
fnp-2911	13	3	a	a	DET
fnp-2911	13	4	motor	motor	NOUN
fnp-2911	13	5	neuron	neuron	NOUN
fnp-2911	13	6	disease	disease	NOUN
fnp-2911	13	7	that	that	PRON
fnp-2911	13	8	primarily	primarily	ADV
fnp-2911	13	9	affects	affect	VERB
fnp-2911	13	10	the	the	DET
fnp-2911	13	11	upper	upper	ADJ
fnp-2911	13	12	and	and	CCONJ
fnp-2911	13	13	lower	low	ADJ
fnp-2911	13	14	motor	motor	NOUN
fnp-2911	13	15	neurons	neuron	NOUN
fnp-2911	13	16	in	in	ADP
fnp-2911	13	17	the	the	DET
fnp-2911	13	18	motor	motor	NOUN
fnp-2911	13	19	cortex	cortex	NOUN
fnp-2911	13	20	and	and	CCONJ
fnp-2911	13	21	spinal	spinal	ADJ
fnp-2911	13	22	cord	cord	NOUN
fnp-2911	13	23	,	,	PUNCT
fnp-2911	13	24	respectively	respectively	ADV
fnp-2911	13	25	,	,	PUNCT
fnp-2911	13	26	whereas	whereas	SCONJ
fnp-2911	13	27	ftd	ftd	PROPN
fnp-2911	13	28	affects	affect	VERB
fnp-2911	13	29	the	the	DET
fnp-2911	13	30	frontal	frontal	ADJ
fnp-2911	13	31	and	and	CCONJ
fnp-2911	13	32	temporal	temporal	ADJ
fnp-2911	13	33	lobes	lobe	NOUN
fnp-2911	13	34	,	,	PUNCT
fnp-2911	13	35	thereby	thereby	ADV
fnp-2911	13	36	affecting	affect	VERB
fnp-2911	13	37	cognition	cognition	NOUN
fnp-2911	13	38	.	.	PUNCT
fnp-2911	14	1	the	the	DET
fnp-2911	14	2	most	most	ADV
fnp-2911	14	3	common	common	ADJ
fnp-2911	14	4	genetic	genetic	ADJ
fnp-2911	14	5	cause	cause	NOUN
fnp-2911	14	6	of	of	ADP
fnp-2911	14	7	familial	familial	ADJ
fnp-2911	14	8	and	and	CCONJ
fnp-2911	14	9	sporadic	sporadic	ADJ
fnp-2911	14	10	cases	case	NOUN
fnp-2911	14	11	of	of	ADP
fnp-2911	14	12	als	al	NOUN
fnp-2911	14	13	and	and	CCONJ
fnp-2911	14	14	ftd	ftd	PROPN
fnp-2911	14	15	was	be	AUX
fnp-2911	14	16	identified	identify	VERB
fnp-2911	14	17	as	as	ADP
fnp-2911	14	18	a	a	DET
fnp-2911	14	19	hexanucleotide	hexanucleotide	NOUN
fnp-2911	14	20	g4c2	g4c2	PUNCT
fnp-2911	14	21	repeat	repeat	NOUN
fnp-2911	14	22	expansion	expansion	NOUN
fnp-2911	14	23	found	find	VERB
fnp-2911	14	24	in	in	ADP
fnp-2911	14	25	the	the	DET
fnp-2911	14	26	gene	gene	NOUN
fnp-2911	14	27	c9orf72	c9orf72	PROPN
fnp-2911	14	28	(	(	PUNCT
fnp-2911	14	29	1	1	NUM
fnp-2911	14	30	,	,	PUNCT
fnp-2911	14	31	2	2	NUM
fnp-2911	14	32	)	)	PUNCT
fnp-2911	14	33	.	.	PUNCT
fnp-2911	15	1	the	the	DET
fnp-2911	15	2	repeat	repeat	NOUN
fnp-2911	15	3	expansion	expansion	NOUN
fnp-2911	15	4	is	be	AUX
fnp-2911	15	5	found	find	VERB
fnp-2911	15	6	in	in	ADP
fnp-2911	15	7	the	the	DET
fnp-2911	15	8	first	first	ADJ
fnp-2911	15	9	intron	intron	NOUN
fnp-2911	15	10	of	of	ADP
fnp-2911	15	11	c9orf72	c9orf72	PROPN
fnp-2911	15	12	and	and	CCONJ
fnp-2911	15	13	can	can	AUX
fnp-2911	15	14	be	be	AUX
fnp-2911	15	15	transcribed	transcribe	VERB
fnp-2911	15	16	into	into	ADP
fnp-2911	15	17	pre	pre	ADJ
fnp-2911	15	18	-	-	NOUN
fnp-2911	15	19	mrna	mrna	NOUN
fnp-2911	15	20	that	that	PRON
fnp-2911	15	21	contains	contain	VERB
fnp-2911	15	22	the	the	DET
fnp-2911	15	23	repeat	repeat	NOUN
fnp-2911	15	24	.	.	PUNCT
fnp-2911	16	1	c9orf72	c9orf72	ADJ
fnp-2911	16	2	protein	protein	NOUN
fnp-2911	16	3	has	have	AUX
fnp-2911	16	4	been	be	AUX
fnp-2911	16	5	predicted	predict	VERB
fnp-2911	16	6	to	to	PART
fnp-2911	16	7	be	be	AUX
fnp-2911	16	8	a	a	DET
fnp-2911	16	9	denn	denn	NOUN
fnp-2911	16	10	rab	rab	NOUN
fnp-2911	16	11	gtpase	gtpase	NOUN
fnp-2911	16	12	,	,	PUNCT
fnp-2911	16	13	and	and	CCONJ
fnp-2911	16	14	shown	show	VERB
fnp-2911	16	15	to	to	PART
fnp-2911	16	16	be	be	AUX
fnp-2911	16	17	involved	involve	VERB
fnp-2911	16	18	in	in	ADP
fnp-2911	16	19	vesicular	vesicular	ADJ
fnp-2911	16	20	trafficking	trafficking	NOUN
fnp-2911	16	21	(	(	PUNCT
fnp-2911	16	22	3	3	NUM
fnp-2911	16	23	-	-	SYM
fnp-2911	16	24	8)	8)	NUM
fnp-2911	16	25	.	.	PUNCT
fnp-2911	17	1	three	three	NUM
fnp-2911	17	2	potential	potential	ADJ
fnp-2911	17	3	mechanisms	mechanism	NOUN
fnp-2911	17	4	of	of	ADP
fnp-2911	17	5	toxicity	toxicity	NOUN
fnp-2911	17	6	have	have	AUX
fnp-2911	17	7	been	be	AUX
fnp-2911	17	8	implicated	implicate	VERB
fnp-2911	17	9	in	in	ADP
fnp-2911	17	10	contributing	contribute	VERB
fnp-2911	17	11	to	to	ADP
fnp-2911	17	12	disease	disease	NOUN
fnp-2911	17	13	:	:	PUNCT
fnp-2911	17	14	haploinsufficiency	haploinsufficiency	NOUN
fnp-2911	17	15	due	due	ADP
fnp-2911	17	16	to	to	ADP
fnp-2911	17	17	reduction	reduction	NOUN
fnp-2911	17	18	of	of	ADP
fnp-2911	17	19	c9orf72	c9orf72	ADJ
fnp-2911	17	20	protein	protein	NOUN
fnp-2911	17	21	;	;	PUNCT
fnp-2911	17	22	rna	rna	NOUN
fnp-2911	17	23	foci	focus	NOUN
fnp-2911	17	24	and	and	CCONJ
fnp-2911	17	25	titration	titration	NOUN
fnp-2911	17	26	of	of	ADP
fnp-2911	17	27	rna	rna	NOUN
fnp-2911	17	28	binding	bind	VERB
fnp-2911	17	29	proteins	protein	NOUN
fnp-2911	17	30	;	;	PUNCT
fnp-2911	17	31	and	and	CCONJ
fnp-2911	17	32	dipeptide	dipeptide	NOUN
fnp-2911	17	33	repeat	repeat	NOUN
fnp-2911	17	34	protein	protein	NOUN
fnp-2911	17	35	aggregates	aggregate	NOUN
fnp-2911	17	36	(	(	PUNCT
fnp-2911	17	37	reviewed	review	VERB
fnp-2911	17	38	in	in	ADP
fnp-2911	17	39	(	(	PUNCT
fnp-2911	17	40	9	9	NUM
fnp-2911	17	41	)	)	PUNCT
fnp-2911	17	42	)	)	PUNCT
fnp-2911	17	43	.	.	PUNCT
fnp-2911	18	1	it	it	PRON
fnp-2911	18	2	is	be	AUX
fnp-2911	18	3	currently	currently	ADV
fnp-2911	18	4	unclear	unclear	ADJ
fnp-2911	18	5	which	which	DET
fnp-2911	18	6	mechanism	mechanism	NOUN
fnp-2911	18	7	contributes	contribute	VERB
fnp-2911	18	8	most	most	ADJ
fnp-2911	18	9	to	to	ADP
fnp-2911	18	10	toxicity	toxicity	NOUN
fnp-2911	18	11	.	.	PUNCT
fnp-2911	19	1	gain	gain	NOUN
fnp-2911	19	2	of	of	ADP
fnp-2911	19	3	toxic	toxic	ADJ
fnp-2911	19	4	function	function	NOUN
fnp-2911	19	5	via	via	ADP
fnp-2911	19	6	rna	rna	NOUN
fnp-2911	19	7	foci	focus	NOUN
fnp-2911	19	8	or	or	CCONJ
fnp-2911	19	9	dipeptide	dipeptide	NOUN
fnp-2911	19	10	repeat	repeat	NOUN
fnp-2911	19	11	proteins	protein	NOUN
fnp-2911	19	12	have	have	AUX
fnp-2911	19	13	been	be	AUX
fnp-2911	19	14	seen	see	VERB
fnp-2911	19	15	in	in	ADP
fnp-2911	19	16	cellular	cellular	ADJ
fnp-2911	19	17	and	and	CCONJ
fnp-2911	19	18	animal	animal	NOUN
fnp-2911	19	19	models	model	NOUN
fnp-2911	19	20	.	.	PUNCT
fnp-2911	20	1	indeed	indeed	ADV
fnp-2911	20	2	,	,	PUNCT
fnp-2911	20	3	several	several	ADJ
fnp-2911	20	4	rna	rna	NOUN
fnp-2911	20	5	binding	bind	VERB
fnp-2911	20	6	proteins	protein	NOUN
fnp-2911	20	7	have	have	AUX
fnp-2911	20	8	been	be	AUX
fnp-2911	20	9	shown	show	VERB
fnp-2911	20	10	to	to	PART
fnp-2911	20	11	colocalize	colocalize	VERB
fnp-2911	20	12	with	with	ADP
fnp-2911	20	13	repeat	repeat	NOUN
fnp-2911	20	14	containing	contain	VERB
fnp-2911	20	15	rna	rna	NOUN
fnp-2911	20	16	within	within	ADP
fnp-2911	20	17	rna	rna	NOUN
fnp-2911	20	18	foci	focus	NOUN
fnp-2911	20	19	,	,	PUNCT
fnp-2911	20	20	suggesting	suggest	VERB
fnp-2911	20	21	that	that	SCONJ
fnp-2911	20	22	rna	rna	NOUN
fnp-2911	20	23	binding	bind	VERB
fnp-2911	20	24	protein	protein	NOUN
fnp-2911	20	25	titration	titration	NOUN
fnp-2911	20	26	may	may	AUX
fnp-2911	20	27	be	be	AUX
fnp-2911	20	28	mediating	mediate	VERB
fnp-2911	20	29	toxicity	toxicity	NOUN
fnp-2911	20	30	(	(	PUNCT
fnp-2911	20	31	10	10	NUM
fnp-2911	20	32	-	-	SYM
fnp-2911	20	33	12	12	NUM
fnp-2911	20	34	)	)	PUNCT
fnp-2911	20	35	.	.	PUNCT
fnp-2911	21	1	models	model	NOUN
fnp-2911	21	2	overexpressing	overexpresse	VERB
fnp-2911	21	3	dipeptide	dipeptide	NOUN
fnp-2911	21	4	repeat	repeat	NOUN
fnp-2911	21	5	proteins	protein	NOUN
fnp-2911	21	6	and/or	and/or	CCONJ
fnp-2911	21	7	mutant	mutant	ADJ
fnp-2911	21	8	rna	rna	NOUN
fnp-2911	21	9	in	in	ADP
fnp-2911	21	10	both	both	DET
fnp-2911	21	11	cell	cell	NOUN
fnp-2911	21	12	and	and	CCONJ
fnp-2911	21	13	animal	animal	NOUN
fnp-2911	21	14	systems	system	NOUN
fnp-2911	21	15	have	have	AUX
fnp-2911	21	16	shown	show	VERB
fnp-2911	21	17	that	that	SCONJ
fnp-2911	21	18	the	the	DET
fnp-2911	21	19	repeat	repeat	NOUN
fnp-2911	21	20	expansion	expansion	NOUN
fnp-2911	21	21	and	and	CCONJ
fnp-2911	21	22	dipeptide	dipeptide	NOUN
fnp-2911	21	23	proteins	protein	NOUN
fnp-2911	21	24	may	may	AUX
fnp-2911	21	25	confer	confer	VERB
fnp-2911	21	26	toxicity	toxicity	NOUN
fnp-2911	21	27	via	via	ADP
fnp-2911	21	28	a	a	DET
fnp-2911	21	29	variety	variety	NOUN
fnp-2911	21	30	of	of	ADP
fnp-2911	21	31	pathways	pathway	NOUN
fnp-2911	21	32	including	include	VERB
fnp-2911	21	33	nucleolar	nucleolar	ADJ
fnp-2911	21	34	stress	stress	NOUN
fnp-2911	21	35	,	,	PUNCT
fnp-2911	21	36	nucleocytoplasmic	nucleocytoplasmic	ADJ
fnp-2911	21	37	transport	transport	NOUN
fnp-2911	21	38	defects	defect	NOUN
fnp-2911	21	39	,	,	PUNCT
fnp-2911	21	40	heterochromatin	heterochromatin	NOUN
fnp-2911	21	41	abnormalities	abnormality	NOUN
fnp-2911	21	42	,	,	PUNCT
fnp-2911	21	43	and	and	CCONJ
fnp-2911	21	44	dna	dna	PROPN
fnp-2911	21	45	damage	damage	NOUN
fnp-2911	21	46	(	(	PUNCT
fnp-2911	21	47	13	13	NUM
fnp-2911	21	48	-	-	SYM
fnp-2911	21	49	32	32	NUM
fnp-2911	21	50	)	)	PUNCT
fnp-2911	21	51	.	.	PUNCT
fnp-2911	22	1	however	however	ADV
fnp-2911	22	2	,	,	PUNCT
fnp-2911	22	3	rna	rna	NOUN
fnp-2911	22	4	foci	focus	NOUN
fnp-2911	22	5	and	and	CCONJ
fnp-2911	22	6	dipeptide	dipeptide	NOUN
fnp-2911	22	7	repeat	repeat	NOUN
fnp-2911	22	8	proteins	protein	NOUN
fnp-2911	22	9	do	do	AUX
fnp-2911	22	10	not	not	PART
fnp-2911	22	11	correlate	correlate	VERB
fnp-2911	22	12	with	with	ADP
fnp-2911	22	13	neurodegeneration	neurodegeneration	NOUN
fnp-2911	22	14	in	in	ADP
fnp-2911	22	15	human	human	ADJ
fnp-2911	22	16	tissues	tissue	NOUN
fnp-2911	22	17	and	and	CCONJ
fnp-2911	22	18	are	be	AUX
fnp-2911	22	19	not	not	PART
fnp-2911	22	20	toxic	toxic	ADJ
fnp-2911	22	21	in	in	ADP
fnp-2911	22	22	some	some	DET
fnp-2911	22	23	experimental	experimental	ADJ
fnp-2911	22	24	models	model	NOUN
fnp-2911	22	25	(	(	PUNCT
fnp-2911	22	26	13	13	NUM
fnp-2911	22	27	-	-	SYM
fnp-2911	22	28	16	16	NUM
fnp-2911	22	29	,	,	PUNCT
fnp-2911	22	30	33	33	NUM
fnp-2911	22	31	-	-	SYM
fnp-2911	22	32	36	36	NUM
fnp-2911	22	33	)	)	PUNCT
fnp-2911	22	34	,	,	PUNCT
fnp-2911	22	35	raising	raise	VERB
fnp-2911	22	36	questions	question	NOUN
fnp-2911	22	37	about	about	ADP
fnp-2911	22	38	the	the	DET
fnp-2911	22	39	relevance	relevance	NOUN
fnp-2911	22	40	of	of	ADP
fnp-2911	22	41	whether	whether	SCONJ
fnp-2911	22	42	these	these	DET
fnp-2911	22	43	pathologies	pathology	NOUN
fnp-2911	22	44	contribute	contribute	VERB
fnp-2911	22	45	to	to	ADP
fnp-2911	22	46	disease	disease	NOUN
fnp-2911	22	47	.	.	PUNCT
fnp-2911	23	1	the	the	DET
fnp-2911	23	2	loss	loss	NOUN
fnp-2911	23	3	of	of	ADP
fnp-2911	23	4	c9orf72	c9orf72	ADJ
fnp-2911	23	5	protein	protein	NOUN
fnp-2911	23	6	has	have	AUX
fnp-2911	23	7	been	be	AUX
fnp-2911	23	8	substantiated	substantiate	VERB
fnp-2911	23	9	by	by	ADP
fnp-2911	23	10	the	the	DET
fnp-2911	23	11	fact	fact	NOUN
fnp-2911	23	12	that	that	SCONJ
fnp-2911	23	13	c9orf72	c9orf72	ADJ
fnp-2911	23	14	expansion	expansion	NOUN
fnp-2911	23	15	carriers	carrier	NOUN
fnp-2911	23	16	have	have	AUX
fnp-2911	23	17	reduced	reduce	VERB
fnp-2911	23	18	c9orf72	c9orf72	PROPN
fnp-2911	23	19	mrna	mrna	PROPN
fnp-2911	23	20	and	and	CCONJ
fnp-2911	23	21	protein	protein	NOUN
fnp-2911	23	22	expression	expression	NOUN
fnp-2911	23	23	(	(	PUNCT
fnp-2911	23	24	1	1	NUM
fnp-2911	23	25	,	,	PUNCT
fnp-2911	23	26	2	2	NUM
fnp-2911	23	27	,	,	PUNCT
fnp-2911	23	28	37	37	NUM
fnp-2911	23	29	,	,	PUNCT
fnp-2911	23	30	38	38	NUM
fnp-2911	23	31	)	)	PUNCT
fnp-2911	23	32	.	.	PUNCT
fnp-2911	24	1	thus	thus	ADV
fnp-2911	24	2	,	,	PUNCT
fnp-2911	24	3	it	it	PRON
fnp-2911	24	4	is	be	AUX
fnp-2911	24	5	possible	possible	ADJ
fnp-2911	24	6	that	that	SCONJ
fnp-2911	24	7	loss	loss	NOUN
fnp-2911	24	8	of	of	ADP
fnp-2911	24	9	c9orf72	c9orf72	ADJ
fnp-2911	24	10	protein	protein	NOUN
fnp-2911	24	11	may	may	AUX
fnp-2911	24	12	contribute	contribute	VERB
fnp-2911	24	13	to	to	ADP
fnp-2911	24	14	disease	disease	NOUN
fnp-2911	24	15	.	.	PUNCT
fnp-2911	25	1	however	however	ADV
fnp-2911	25	2	,	,	PUNCT
fnp-2911	25	3	knockout	knockout	NOUN
fnp-2911	25	4	mouse	mouse	NOUN
fnp-2911	25	5	models	model	NOUN
fnp-2911	25	6	of	of	ADP
fnp-2911	25	7	c9orf72	c9orf72	PROPN
fnp-2911	25	8	do	do	AUX
fnp-2911	25	9	not	not	PART
fnp-2911	25	10	show	show	VERB
fnp-2911	25	11	neuronal	neuronal	ADJ
fnp-2911	25	12	defects	defect	NOUN
fnp-2911	25	13	but	but	CCONJ
fnp-2911	25	14	,	,	PUNCT
fnp-2911	25	15	rather	rather	ADV
fnp-2911	25	16	,	,	PUNCT
fnp-2911	25	17	exhibit	exhibit	VERB
fnp-2911	25	18	an	an	DET
fnp-2911	25	19	inflammatory	inflammatory	ADJ
fnp-2911	25	20	phenotype	phenotype	NOUN
fnp-2911	25	21	(	(	PUNCT
fnp-2911	25	22	39	39	NUM
fnp-2911	25	23	-	-	SYM
fnp-2911	25	24	41	41	NUM
fnp-2911	25	25	)	)	PUNCT
fnp-2911	25	26	,	,	PUNCT
fnp-2911	25	27	although	although	SCONJ
fnp-2911	25	28	reduction	reduction	NOUN
fnp-2911	25	29	of	of	ADP
fnp-2911	25	30	c9orf72	c9orf72	ADJ
fnp-2911	25	31	protein	protein	NOUN
fnp-2911	25	32	appears	appear	VERB
fnp-2911	25	33	to	to	PART
fnp-2911	25	34	exacerbate	exacerbate	VERB
fnp-2911	25	35	phenotypes	phenotype	NOUN
fnp-2911	25	36	in	in	ADP
fnp-2911	25	37	mice	mice	NOUN
fnp-2911	25	38	overexpressing	overexpresse	VERB
fnp-2911	25	39	mutant	mutant	ADJ
fnp-2911	25	40	c9orf72	c9orf72	PROPN
fnp-2911	25	41	rna	rna	PROPN
fnp-2911	25	42	(	(	PUNCT
fnp-2911	25	43	42	42	NUM
fnp-2911	25	44	)	)	PUNCT
fnp-2911	25	45	.	.	PUNCT
fnp-2911	26	1	we	we	PRON
fnp-2911	26	2	have	have	AUX
fnp-2911	26	3	shown	show	VERB
fnp-2911	26	4	that	that	SCONJ
fnp-2911	26	5	a	a	DET
fnp-2911	26	6	subset	subset	NOUN
fnp-2911	26	7	of	of	ADP
fnp-2911	26	8	c9orf72	c9orf72	ADJ
fnp-2911	26	9	expansion	expansion	NOUN
fnp-2911	26	10	carriers	carrier	NOUN
fnp-2911	26	11	exhibit	exhibit	VERB
fnp-2911	26	12	c9orf72	c9orf72	ADJ
fnp-2911	26	13	promoter	promoter	NOUN
fnp-2911	26	14	methylation	methylation	NOUN
fnp-2911	26	15	,	,	PUNCT
fnp-2911	26	16	and	and	CCONJ
fnp-2911	26	17	this	this	PRON
fnp-2911	26	18	is	be	AUX
fnp-2911	26	19	associated	associate	VERB
fnp-2911	26	20	with	with	ADP
fnp-2911	26	21	reduced	reduce	VERB
fnp-2911	26	22	c9orf72	c9orf72	PROPN
fnp-2911	26	23	associated	associated	PROPN
fnp-2911	26	24	pathology	pathology	NOUN
fnp-2911	26	25	,	,	PUNCT
fnp-2911	26	26	later	later	ADV
fnp-2911	26	27	age	age	NOUN
fnp-2911	26	28	at	at	ADP
fnp-2911	26	29	death	death	NOUN
fnp-2911	26	30	in	in	ADP
fnp-2911	26	31	ftd	ftd	PROPN
fnp-2911	26	32	patients	patient	NOUN
fnp-2911	26	33	,	,	PUNCT
fnp-2911	26	34	slower	slow	ADJ
fnp-2911	26	35	rates	rate	NOUN
fnp-2911	26	36	of	of	ADP
fnp-2911	26	37	cerebral	cerebral	ADJ
fnp-2911	26	38	atrophy	atrophy	NOUN
fnp-2911	26	39	,	,	PUNCT
fnp-2911	26	40	and	and	CCONJ
fnp-2911	26	41	improved	improve	VERB
fnp-2911	26	42	cognitive	cognitive	ADJ
fnp-2911	26	43	ability	ability	NOUN
fnp-2911	26	44	(	(	PUNCT
fnp-2911	26	45	43	43	NUM
fnp-2911	26	46	-	-	SYM
fnp-2911	26	47	45	45	NUM
fnp-2911	26	48	)	)	PUNCT
fnp-2911	26	49	.	.	PUNCT
fnp-2911	27	1	moreover	moreover	ADV
fnp-2911	27	2	,	,	PUNCT
fnp-2911	27	3	the	the	DET
fnp-2911	27	4	gnomad	gnomad	ADJ
fnp-2911	27	5	human	human	ADJ
fnp-2911	27	6	genetics	genetic	NOUN
fnp-2911	27	7	database	database	NOUN
fnp-2911	27	8	indicates	indicate	VERB
fnp-2911	27	9	that	that	SCONJ
fnp-2911	27	10	missense	missense	NOUN
fnp-2911	27	11	and	and	CCONJ
fnp-2911	27	12	loss	loss	NOUN
fnp-2911	27	13	of	of	ADP
fnp-2911	27	14	function	function	NOUN
fnp-2911	27	15	c9orf72	c9orf72	PROPN
fnp-2911	27	16	mutations	mutation	NOUN
fnp-2911	27	17	are	be	AUX
fnp-2911	27	18	tolerated	tolerate	VERB
fnp-2911	27	19	and	and	CCONJ
fnp-2911	27	20	present	present	ADJ
fnp-2911	27	21	in	in	ADP
fnp-2911	27	22	control	control	NOUN
fnp-2911	27	23	populations	population	NOUN
fnp-2911	27	24	(	(	PUNCT
fnp-2911	27	25	46	46	NUM
fnp-2911	27	26	)	)	PUNCT
fnp-2911	27	27	.	.	PUNCT
fnp-2911	28	1	consequently	consequently	ADV
fnp-2911	28	2	,	,	PUNCT
fnp-2911	28	3	the	the	DET
fnp-2911	28	4	pathogenic	pathogenic	ADJ
fnp-2911	28	5	role	role	NOUN
fnp-2911	28	6	of	of	ADP
fnp-2911	28	7	the	the	DET
fnp-2911	28	8	loss	loss	NOUN
fnp-2911	28	9	of	of	ADP
fnp-2911	28	10	c9orf72	c9orf72	ADJ
fnp-2911	28	11	protein	protein	NOUN
fnp-2911	28	12	in	in	ADP
fnp-2911	28	13	als	al	NOUN
fnp-2911	28	14	/	/	SYM
fnp-2911	28	15	ftd	ftd	NOUN
fnp-2911	28	16	is	be	AUX
fnp-2911	28	17	not	not	PART
fnp-2911	28	18	entirely	entirely	ADV
fnp-2911	28	19	clear	clear	ADJ
fnp-2911	28	20	,	,	PUNCT
fnp-2911	28	21	and	and	CCONJ
fnp-2911	28	22	overall	overall	ADV
fnp-2911	28	23	it	it	PRON
fnp-2911	28	24	remains	remain	VERB
fnp-2911	28	25	unclear	unclear	ADJ
fnp-2911	28	26	which	which	DET
fnp-2911	28	27	mechanism	mechanism	NOUN
fnp-2911	28	28	of	of	ADP
fnp-2911	28	29	toxicity	toxicity	NOUN
fnp-2911	28	30	contributes	contribute	VERB
fnp-2911	28	31	most	most	ADJ
fnp-2911	28	32	to	to	PART
fnp-2911	28	33	disease	disease	VERB
fnp-2911	28	34	.	.	PUNCT
fnp-2911	29	1	efforts	effort	NOUN
fnp-2911	29	2	to	to	PART
fnp-2911	29	3	better	well	ADV
fnp-2911	29	4	understand	understand	VERB
fnp-2911	29	5	these	these	DET
fnp-2911	29	6	mechanisms	mechanism	NOUN
fnp-2911	29	7	include	include	VERB
fnp-2911	29	8	transcriptomic	transcriptomic	ADJ
fnp-2911	29	9	studies	study	NOUN
fnp-2911	29	10	to	to	PART
fnp-2911	29	11	determine	determine	VERB
fnp-2911	29	12	whether	whether	SCONJ
fnp-2911	29	13	rna	rna	NOUN
fnp-2911	29	14	dysregulation	dysregulation	NOUN
fnp-2911	29	15	can	can	AUX
fnp-2911	29	16	contribute	contribute	VERB
fnp-2911	29	17	to	to	ADP
fnp-2911	29	18	neurodegeneration	neurodegeneration	NOUN
fnp-2911	29	19	.	.	PUNCT
fnp-2911	30	1	indeed	indeed	ADV
fnp-2911	30	2	,	,	PUNCT
fnp-2911	30	3	frontal	frontal	ADJ
fnp-2911	30	4	cortical	cortical	ADJ
fnp-2911	30	5	and	and	CCONJ
fnp-2911	30	6	motor	motor	NOUN
fnp-2911	30	7	neuron	neuron	NOUN
fnp-2911	30	8	transcriptome	transcriptome	ADJ
fnp-2911	30	9	analysis	analysis	NOUN
fnp-2911	30	10	from	from	ADP
fnp-2911	30	11	als	als	NOUN
fnp-2911	30	12	patients	patient	NOUN
fnp-2911	30	13	showed	show	VERB
fnp-2911	30	14	splicing	splicing	NOUN
fnp-2911	30	15	changes	change	NOUN
fnp-2911	30	16	,	,	PUNCT
fnp-2911	30	17	dysregulation	dysregulation	NOUN
fnp-2911	30	18	of	of	ADP
fnp-2911	30	19	rna	rna	NOUN
fnp-2911	30	20	processing	processing	NOUN
fnp-2911	30	21	pathways	pathway	NOUN
fnp-2911	30	22	,	,	PUNCT
fnp-2911	30	23	and	and	CCONJ
fnp-2911	30	24	alternative	alternative	ADJ
fnp-2911	30	25	polyadenylation	polyadenylation	NOUN
fnp-2911	30	26	insporadic	insporadic	ADJ
fnp-2911	30	27	and	and	CCONJ
fnp-2911	30	28	c9orf72	c9orf72	ADJ
fnp-2911	30	29	expansion	expansion	NOUN
fnp-2911	30	30	carriers	carrier	NOUN
fnp-2911	30	31	(	(	PUNCT
fnp-2911	30	32	47	47	NUM
fnp-2911	30	33	-	-	SYM
fnp-2911	30	34	49	49	NUM
fnp-2911	30	35	)	)	PUNCT
fnp-2911	30	36	.	.	PUNCT
fnp-2911	31	1	more	more	ADV
fnp-2911	31	2	recently	recently	ADV
fnp-2911	31	3	,	,	PUNCT
fnp-2911	31	4	a	a	DET
fnp-2911	31	5	large	large	ADJ
fnp-2911	31	6	transcriptome	transcriptome	ADJ
fnp-2911	31	7	study	study	NOUN
fnp-2911	31	8	of	of	ADP
fnp-2911	31	9	c9orf72	c9orf72	PROPN
fnp-2911	31	10	cases	case	NOUN
fnp-2911	31	11	found	find	VERB
fnp-2911	31	12	changes	change	NOUN
fnp-2911	31	13	in	in	ADP
fnp-2911	31	14	genes	gene	NOUN
fnp-2911	31	15	linked	link	VERB
fnp-2911	31	16	to	to	ADP
fnp-2911	31	17	vesicular	vesicular	ADJ
fnp-2911	31	18	transport	transport	NOUN
fnp-2911	31	19	(	(	PUNCT
fnp-2911	31	20	8)	8)	NUM
fnp-2911	31	21	.	.	PUNCT
fnp-2911	32	1	these	these	DET
fnp-2911	32	2	studies	study	NOUN
fnp-2911	32	3	are	be	AUX
fnp-2911	32	4	sometimes	sometimes	ADV
fnp-2911	32	5	complicated	complicate	VERB
fnp-2911	32	6	by	by	ADP
fnp-2911	32	7	the	the	DET
fnp-2911	32	8	complex	complex	ADJ
fnp-2911	32	9	cellular	cellular	ADJ
fnp-2911	32	10	composition	composition	NOUN
fnp-2911	32	11	of	of	ADP
fnp-2911	32	12	brain	brain	NOUN
fnp-2911	32	13	tissue	tissue	NOUN
fnp-2911	32	14	which	which	PRON
fnp-2911	32	15	includes	include	VERB
fnp-2911	32	16	neuronal	neuronal	ADJ
fnp-2911	32	17	subtypes	subtype	NOUN
fnp-2911	32	18	,	,	PUNCT
fnp-2911	32	19	oligodendrocytes	oligodendrocyte	NOUN
fnp-2911	32	20	,	,	PUNCT
fnp-2911	32	21	microglia	microglia	ADJ
fnp-2911	32	22	,	,	PUNCT
fnp-2911	32	23	astrocytes	astrocyte	NOUN
fnp-2911	32	24	,	,	PUNCT
fnp-2911	32	25	vascular	vascular	ADJ
fnp-2911	32	26	cells	cell	NOUN
fnp-2911	32	27	and	and	CCONJ
fnp-2911	32	28	other	other	ADJ
fnp-2911	32	29	cell	cell	NOUN
fnp-2911	32	30	types	type	NOUN
fnp-2911	32	31	.	.	PUNCT
fnp-2911	33	1	laser	laser	NOUN
fnp-2911	33	2	capture	capture	VERB
fnp-2911	33	3	microdissected	microdissected	ADJ
fnp-2911	33	4	tissue	tissue	NOUN
fnp-2911	33	5	studies	study	NOUN
fnp-2911	33	6	have	have	AUX
fnp-2911	33	7	been	be	AUX
fnp-2911	33	8	very	very	ADV
fnp-2911	33	9	useful	useful	ADJ
fnp-2911	33	10	(	(	PUNCT
fnp-2911	33	11	50	50	NUM
fnp-2911	33	12	)	)	PUNCT
fnp-2911	33	13	but	but	CCONJ
fnp-2911	33	14	is	be	AUX
fnp-2911	33	15	labor	labor	NOUN
fnp-2911	33	16	intensive	intensive	ADJ
fnp-2911	33	17	and	and	CCONJ
fnp-2911	33	18	often	often	ADV
fnp-2911	33	19	is	be	AUX
fnp-2911	33	20	technically	technically	ADV
fnp-2911	33	21	difficult	difficult	ADJ
fnp-2911	33	22	due	due	ADJ
fnp-2911	33	23	to	to	ADP
fnp-2911	33	24	relatively	relatively	ADV
fnp-2911	33	25	low	low	ADJ
fnp-2911	33	26	yield	yield	NOUN
fnp-2911	33	27	and	and	CCONJ
fnp-2911	33	28	preprocessing	preprocesse	VERB
fnp-2911	33	29	steps	step	NOUN
fnp-2911	33	30	that	that	PRON
fnp-2911	33	31	can	can	AUX
fnp-2911	33	32	affect	affect	VERB
fnp-2911	33	33	rna	rna	NOUN
fnp-2911	33	34	quality	quality	NOUN
fnp-2911	33	35	(	(	PUNCT
fnp-2911	33	36	51	51	NUM
fnp-2911	33	37	)	)	PUNCT
fnp-2911	33	38	.	.	PUNCT
fnp-2911	34	1	single	single	ADJ
fnp-2911	34	2	cell	cell	NOUN
fnp-2911	34	3	rna	rna	NOUN
fnp-2911	34	4	sequencing	sequencing	NOUN
fnp-2911	34	5	methods	method	NOUN
fnp-2911	34	6	have	have	AUX
fnp-2911	34	7	recently	recently	ADV
fnp-2911	34	8	addressed	address	VERB
fnp-2911	34	9	the	the	DET
fnp-2911	34	10	issue	issue	NOUN
fnp-2911	34	11	of	of	ADP
fnp-2911	34	12	complex	complex	ADJ
fnp-2911	34	13	cellular	cellular	ADJ
fnp-2911	34	14	mixtures	mixture	NOUN
fnp-2911	34	15	within	within	ADP
fnp-2911	34	16	tissue	tissue	NOUN
fnp-2911	34	17	but	but	CCONJ
fnp-2911	34	18	suffer	suffer	VERB
fnp-2911	34	19	from	from	ADP
fnp-2911	34	20	low	low	ADJ
fnp-2911	34	21	coverage	coverage	NOUN
fnp-2911	34	22	and	and	CCONJ
fnp-2911	34	23	data	datum	NOUN
fnp-2911	34	24	sparsity	sparsity	NOUN
fnp-2911	34	25	.	.	PUNCT
fnp-2911	35	1	we	we	PRON
fnp-2911	35	2	have	have	AUX
fnp-2911	35	3	previously	previously	ADV
fnp-2911	35	4	reported	report	VERB
fnp-2911	35	5	the	the	DET
fnp-2911	35	6	use	use	NOUN
fnp-2911	35	7	of	of	ADP
fnp-2911	35	8	fluorescence	fluorescence	NOUN
fnp-2911	35	9	activated	activate	VERB
fnp-2911	35	10	cell	cell	NOUN
fnp-2911	35	11	sorting	sort	VERB
fnp-2911	35	12	(	(	PUNCT
fnp-2911	35	13	facs	fac	NOUN
fnp-2911	35	14	)	)	PUNCT
fnp-2911	35	15	to	to	PART
fnp-2911	35	16	identify	identify	VERB
fnp-2911	35	17	transcriptome	transcriptome	ADJ
fnp-2911	35	18	signatures	signature	NOUN
fnp-2911	35	19	in	in	ADP
fnp-2911	35	20	neuronal	neuronal	ADJ
fnp-2911	35	21	nuclei	nucleus	NOUN
fnp-2911	35	22	without	without	ADP
fnp-2911	35	23	tdp-43	tdp-43	PROPN
fnp-2911	35	24	from	from	ADP
fnp-2911	35	25	post	post	ADJ
fnp-2911	35	26	-	-	ADJ
fnp-2911	35	27	mortem	mortem	ADJ
fnp-2911	35	28	brain	brain	NOUN
fnp-2911	35	29	in	in	ADP
fnp-2911	35	30	als	al	NOUN
fnp-2911	35	31	/	/	SYM
fnp-2911	35	32	ftd	ftd	NOUN
fnp-2911	35	33	patients	patient	NOUN
fnp-2911	35	34	(	(	PUNCT
fnp-2911	35	35	52	52	NUM
fnp-2911	35	36	)	)	PUNCT
fnp-2911	35	37	.	.	PUNCT
fnp-2911	36	1	here	here	ADV
fnp-2911	36	2	,	,	PUNCT
fnp-2911	36	3	we	we	PRON
fnp-2911	36	4	have	have	AUX
fnp-2911	36	5	used	use	VERB
fnp-2911	36	6	the	the	DET
fnp-2911	36	7	same	same	ADJ
fnp-2911	36	8	method	method	NOUN
fnp-2911	36	9	to	to	PART
fnp-2911	36	10	determine	determine	VERB
fnp-2911	36	11	the	the	DET
fnp-2911	36	12	role	role	NOUN
fnp-2911	36	13	of	of	ADP
fnp-2911	36	14	the	the	DET
fnp-2911	36	15	c9orf72	c9orf72	PROPN
fnp-2911	36	16	repeat	repeat	NOUN
fnp-2911	36	17	expansion	expansion	NOUN
fnp-2911	36	18	in	in	ADP
fnp-2911	36	19	post	post	ADJ
fnp-2911	36	20	-	-	ADJ
fnp-2911	36	21	mortem	mortem	ADJ
fnp-2911	36	22	neurons	neuron	NOUN
fnp-2911	36	23	from	from	ADP
fnp-2911	36	24	als	al	NOUN
fnp-2911	36	25	/	/	SYM
fnp-2911	36	26	ftd	ftd	NOUN
fnp-2911	36	27	patients	patient	NOUN
fnp-2911	36	28	.	.	PUNCT
fnp-2911	37	1	compared	compare	VERB
fnp-2911	37	2	to	to	ADP
fnp-2911	37	3	the	the	DET
fnp-2911	37	4	profound	profound	ADJ
fnp-2911	37	5	transcriptome	transcriptome	ADJ
fnp-2911	37	6	changes	change	NOUN
fnp-2911	37	7	associated	associate	VERB
fnp-2911	37	8	with	with	ADP
fnp-2911	37	9	the	the	DET
fnp-2911	37	10	loss	loss	NOUN
fnp-2911	37	11	of	of	ADP
fnp-2911	37	12	normal	normal	ADJ
fnp-2911	37	13	nuclear	nuclear	ADJ
fnp-2911	37	14	tdp-43	tdp-43	NOUN
fnp-2911	37	15	protein	protein	NOUN
fnp-2911	37	16	(	(	PUNCT
fnp-2911	37	17	52	52	NUM
fnp-2911	37	18	)	)	PUNCT
fnp-2911	37	19	,	,	PUNCT
fnp-2911	37	20	we	we	PRON
fnp-2911	37	21	found	find	VERB
fnp-2911	37	22	that	that	SCONJ
fnp-2911	37	23	the	the	DET
fnp-2911	37	24	c9orf72	c9orf72	PROPN
fnp-2911	37	25	mutation	mutation	NOUN
fnp-2911	37	26	was	be	AUX
fnp-2911	37	27	associated	associate	VERB
fnp-2911	37	28	with	with	ADP
fnp-2911	37	29	relatively	relatively	ADV
fnp-2911	37	30	mild	mild	ADJ
fnp-2911	37	31	gene	gene	NOUN
fnp-2911	37	32	expression	expression	NOUN
fnp-2911	37	33	changes	change	NOUN
fnp-2911	37	34	and	and	CCONJ
fnp-2911	37	35	mild	mild	ADJ
fnp-2911	37	36	splicing	splicing	NOUN
fnp-2911	37	37	changes	change	NOUN
fnp-2911	37	38	.	.	PUNCT
fnp-2911	38	1	moreover	moreover	ADV
fnp-2911	38	2	,	,	PUNCT
fnp-2911	38	3	the	the	DET
fnp-2911	38	4	molecular	molecular	ADJ
fnp-2911	38	5	signature	signature	NOUN
fnp-2911	38	6	is	be	AUX
fnp-2911	38	7	largely	largely	ADV
fnp-2911	38	8	associated	associate	VERB
fnp-2911	38	9	with	with	ADP
fnp-2911	38	10	a	a	DET
fnp-2911	38	11	loss	loss	NOUN
fnp-2911	38	12	of	of	ADP
fnp-2911	38	13	c9orf72	c9orf72	PROPN
fnp-2911	38	14	function	function	NOUN
fnp-2911	38	15	,	,	PUNCT
fnp-2911	38	16	and	and	CCONJ
fnp-2911	38	17	not	not	PART
fnp-2911	38	18	a	a	DET
fnp-2911	38	19	gain	gain	NOUN
fnp-2911	38	20	of	of	ADP
fnp-2911	38	21	toxic	toxic	ADJ
fnp-2911	38	22	rna	rna	NOUN
fnp-2911	38	23	or	or	CCONJ
fnp-2911	38	24	dipeptide	dipeptide	NOUN
fnp-2911	38	25	repeat	repeat	NOUN
fnp-2911	38	26	aggregates	aggregate	NOUN
fnp-2911	38	27	.	.	PUNCT
fnp-2911	39	1	materials	material	NOUN
fnp-2911	39	2	and	and	CCONJ
fnp-2911	39	3	methods	method	NOUN
fnp-2911	39	4	clinical	clinical	ADJ
fnp-2911	39	5	and	and	CCONJ
fnp-2911	39	6	pathologic	pathologic	ADJ
fnp-2911	39	7	assessment	assessment	NOUN
fnp-2911	39	8	human	human	ADJ
fnp-2911	39	9	autopsy	autopsy	ADJ
fnp-2911	39	10	tissue	tissue	NOUN
fnp-2911	39	11	was	be	AUX
fnp-2911	39	12	obtained	obtain	VERB
fnp-2911	39	13	from	from	ADP
fnp-2911	39	14	the	the	DET
fnp-2911	39	15	university	university	PROPN
fnp-2911	39	16	of	of	ADP
fnp-2911	39	17	pennsylvania	pennsylvania	PROPN
fnp-2911	39	18	center	center	PROPN
fnp-2911	39	19	for	for	ADP
fnp-2911	39	20	neurodegenerative	neurodegenerative	ADJ
fnp-2911	39	21	disease	disease	NOUN
fnp-2911	39	22	research	research	NOUN
fnp-2911	39	23	brain	brain	NOUN
fnp-2911	39	24	bank	bank	PROPN
fnp-2911	39	25	as	as	SCONJ
fnp-2911	39	26	described	describe	VERB
fnp-2911	39	27	(	(	PUNCT
fnp-2911	39	28	53	53	NUM
fnp-2911	39	29	)	)	PUNCT
fnp-2911	39	30	.	.	PUNCT
fnp-2911	40	1	informed	inform	VERB
fnp-2911	40	2	consent	consent	NOUN
fnp-2911	40	3	from	from	ADP
fnp-2911	40	4	next	next	ADJ
fnp-2911	40	5	of	of	ADP
fnp-2911	40	6	kin	kin	PROPN
fnp-2911	40	7	was	be	AUX
fnp-2911	40	8	obtained	obtain	VERB
fnp-2911	40	9	for	for	ADP
fnp-2911	40	10	every	every	DET
fnp-2911	40	11	case	case	NOUN
fnp-2911	40	12	.	.	PUNCT
fnp-2911	41	1	isolation	isolation	NOUN
fnp-2911	41	2	was	be	AUX
fnp-2911	41	3	performed	perform	VERB
fnp-2911	41	4	exactly	exactly	ADV
fnp-2911	41	5	as	as	ADV
fnp-2911	41	6	previously	previously	ADV
fnp-2911	41	7	described	describe	VERB
fnp-2911	41	8	(	(	PUNCT
fnp-2911	41	9	52	52	NUM
fnp-2911	41	10	)	)	PUNCT
fnp-2911	41	11	.	.	PUNCT
fnp-2911	42	1	briefly	briefly	NOUN
fnp-2911	42	2	,	,	PUNCT
fnp-2911	42	3	mid	mid	ADJ
fnp-2911	42	4	-	-	ADJ
fnp-2911	42	5	frontal	frontal	ADJ
fnp-2911	42	6	neocortex	neocortex	NOUN
fnp-2911	42	7	of	of	ADP
fnp-2911	42	8	all	all	DET
fnp-2911	42	9	cases	case	NOUN
fnp-2911	42	10	were	be	AUX
fnp-2911	42	11	dounce	dounce	NOUN
fnp-2911	42	12	homogenized	homogenize	VERB
fnp-2911	42	13	using	use	VERB
fnp-2911	42	14	pestil	pestil	PROPN
fnp-2911	42	15	b	b	PROPN
fnp-2911	42	16	(	(	PUNCT
fnp-2911	42	17	kimble	kimble	ADJ
fnp-2911	42	18	chase	chase	NOUN
fnp-2911	42	19	)	)	PUNCT
fnp-2911	42	20	in	in	ADP
fnp-2911	42	21	0.25	0.25	NUM
fnp-2911	42	22	m	m	NOUN
fnp-2911	42	23	sucrose	sucrose	NOUN
fnp-2911	42	24	and	and	CCONJ
fnp-2911	42	25	adjusted	adjust	VERB
fnp-2911	42	26	to	to	ADP
fnp-2911	42	27	final	final	ADJ
fnp-2911	42	28	molarity	molarity	NOUN
fnp-2911	42	29	of	of	ADP
fnp-2911	42	30	1.6	1.6	NUM
fnp-2911	42	31	m	m	NOUN
fnp-2911	42	32	sucrose	sucrose	VERB
fnp-2911	42	33	in	in	ADP
fnp-2911	42	34	tkm	tkm	PROPN
fnp-2911	42	35	.	.	PUNCT
fnp-2911	43	1	the	the	DET
fnp-2911	43	2	homogenate	homogenate	NOUN
fnp-2911	43	3	was	be	AUX
fnp-2911	43	4	spun	spin	VERB
fnp-2911	43	5	on	on	ADP
fnp-2911	43	6	a	a	DET
fnp-2911	43	7	1.8	1.8	NUM
fnp-2911	43	8	m	m	NOUN
fnp-2911	43	9	sucrose	sucrose	ADJ
fnp-2911	43	10	cushion	cushion	NOUN
fnp-2911	43	11	on	on	ADP
fnp-2911	43	12	the	the	DET
fnp-2911	43	13	beckman	beckman	PROPN
fnp-2911	43	14	coulter	coulter	PROPN
fnp-2911	43	15	xpn-80	xpn-80	X
fnp-2911	43	16	ultracentrifuge	ultracentrifuge	PROPN
fnp-2911	43	17	at	at	ADP
fnp-2911	43	18	40,000	40,000	NUM
fnp-2911	43	19	g	g	NOUN
fnp-2911	43	20	for	for	ADP
fnp-2911	43	21	40	40	NUM
fnp-2911	43	22	minutes	minute	NOUN
fnp-2911	43	23	at	at	ADP
fnp-2911	43	24	4	4	NUM
fnp-2911	43	25	°	°	ADP
fnp-2911	43	26	c	c	NOUN
fnp-2911	43	27	(	(	PUNCT
fnp-2911	43	28	beckman	beckman	PROPN
fnp-2911	43	29	coulter	coulter	PROPN
fnp-2911	43	30	inc	inc	PROPN
fnp-2911	43	31	,	,	PUNCT
fnp-2911	43	32	indianapolis	indianapolis	PROPN
fnp-2911	43	33	,	,	PUNCT
fnp-2911	43	34	in	in	ADP
fnp-2911	43	35	,	,	PUNCT
fnp-2911	43	36	usa	usa	PROPN
fnp-2911	43	37	)	)	PUNCT
fnp-2911	43	38	.	.	PUNCT
fnp-2911	44	1	isolated	isolate	VERB
fnp-2911	44	2	nuclei	nucleus	NOUN
fnp-2911	44	3	were	be	AUX
fnp-2911	44	4	stained	stain	VERB
fnp-2911	44	5	with	with	ADP
fnp-2911	44	6	alexa	alexa	ADJ
fnp-2911	44	7	fluor	fluor	NOUN
fnp-2911	44	8	647	647	NUM
fnp-2911	44	9	conjugated	conjugate	VERB
fnp-2911	44	10	to	to	ADP
fnp-2911	44	11	2089	2089	NUM
fnp-2911	44	12	(	(	PUNCT
fnp-2911	44	13	rabbit	rabbit	NOUN
fnp-2911	44	14	polyclonal	polyclonal	ADJ
fnp-2911	44	15	c	c	NOUN
fnp-2911	44	16	-	-	PUNCT
fnp-2911	44	17	terminal	terminal	ADJ
fnp-2911	44	18	anti	anti	ADJ
fnp-2911	44	19	-	-	ADJ
fnp-2911	44	20	tdp-43	tdp-43	ADJ
fnp-2911	44	21	antibody	antibody	NOUN
fnp-2911	44	22	,	,	PUNCT
fnp-2911	44	23	center	center	NOUN
fnp-2911	44	24	for	for	ADP
fnp-2911	44	25	neurodegenerative	neurodegenerative	ADJ
fnp-2911	44	26	disease	disease	NOUN
fnp-2911	44	27	research	research	NOUN
fnp-2911	44	28	,	,	PUNCT
fnp-2911	44	29	university	university	NOUN
fnp-2911	44	30	of	of	ADP
fnp-2911	44	31	pennsylvania	pennsylvania	PROPN
fnp-2911	44	32	)	)	PUNCT
fnp-2911	44	33	,	,	PUNCT
fnp-2911	44	34	alexa	alexa	NOUN
fnp-2911	44	35	fluor	fluor	NOUN
fnp-2911	44	36	488	488	NUM
fnp-2911	44	37	conjugated	conjugate	VERB
fnp-2911	44	38	neun	neun	NOUN
fnp-2911	44	39	(	(	PUNCT
fnp-2911	44	40	emd	emd	PROPN
fnp-2911	44	41	millipore	millipore	PROPN
fnp-2911	44	42	,	,	PUNCT
fnp-2911	44	43	billerica	billerica	PROPN
fnp-2911	44	44	,	,	PUNCT
fnp-2911	44	45	ma	ma	PROPN
fnp-2911	44	46	,	,	PUNCT
fnp-2911	44	47	usa	usa	PROPN
fnp-2911	44	48	)	)	PUNCT
fnp-2911	44	49	,	,	PUNCT
fnp-2911	44	50	and	and	CCONJ
fnp-2911	44	51	dapi	dapi	PROPN
fnp-2911	44	52	(	(	PUNCT
fnp-2911	44	53	invitrogen	invitrogen	PROPN
fnp-2911	44	54	,	,	PUNCT
fnp-2911	44	55	carlsbad	carlsbad	PROPN
fnp-2911	44	56	,	,	PUNCT
fnp-2911	44	57	ca	ca	PROPN
fnp-2911	44	58	,	,	PUNCT
fnp-2911	44	59	usa	usa	PROPN
fnp-2911	44	60	)	)	PUNCT
fnp-2911	44	61	.	.	PUNCT
fnp-2911	45	1	alexa	alexa	NOUN
fnp-2911	45	2	fluor	fluor	NOUN
fnp-2911	45	3	647	647	NUM
fnp-2911	45	4	was	be	AUX
fnp-2911	45	5	conjugated	conjugate	VERB
fnp-2911	45	6	to	to	ADP
fnp-2911	45	7	2089	2089	NUM
fnp-2911	45	8	according	accord	VERB
fnp-2911	45	9	to	to	ADP
fnp-2911	45	10	the	the	DET
fnp-2911	45	11	apex	apex	NOUN
fnp-2911	45	12	alexa	alexa	NOUN
fnp-2911	45	13	fluor	fluor	NOUN
fnp-2911	45	14	647	647	NUM
fnp-2911	45	15	antibody	antibody	NOUN
fnp-2911	45	16	labeling	labeling	NOUN
fnp-2911	45	17	kit	kit	NOUN
fnp-2911	45	18	protocol	protocol	NOUN
fnp-2911	45	19	(	(	PUNCT
fnp-2911	45	20	thermo	thermo	NOUN
fnp-2911	45	21	fisher	fisher	PROPN
fnp-2911	45	22	scientific	scientific	PROPN
fnp-2911	45	23	,	,	PUNCT
fnp-2911	45	24	waltham	waltham	PROPN
fnp-2911	45	25	,	,	PUNCT
fnp-2911	45	26	ma	ma	PROPN
fnp-2911	45	27	,	,	PUNCT
fnp-2911	45	28	usa	usa	PROPN
fnp-2911	45	29	)	)	PUNCT
fnp-2911	45	30	.	.	PUNCT
fnp-2911	46	1	stained	stain	VERB
fnp-2911	46	2	nuclei	nucleus	NOUN
fnp-2911	46	3	were	be	AUX
fnp-2911	46	4	sorted	sort	VERB
fnp-2911	46	5	for	for	ADP
fnp-2911	46	6	single	single	ADJ
fnp-2911	46	7	cells	cell	NOUN
fnp-2911	46	8	containing	contain	VERB
fnp-2911	46	9	tdp-43	tdp-43	NOUN
fnp-2911	46	10	and	and	CCONJ
fnp-2911	46	11	neun	neun	NOUN
fnp-2911	46	12	on	on	ADP
fnp-2911	46	13	the	the	DET
fnp-2911	46	14	bd	bd	PROPN
fnp-2911	46	15	facsaria	facsaria	PROPN
fnp-2911	46	16	ii	ii	PROPN
fnp-2911	46	17	(	(	PUNCT
fnp-2911	46	18	bd	bd	PROPN
fnp-2911	46	19	biosciences	bioscience	NOUN
fnp-2911	46	20	,	,	PUNCT
fnp-2911	46	21	san	san	PROPN
fnp-2911	46	22	jose	jose	PROPN
fnp-2911	46	23	,	,	PUNCT
fnp-2911	46	24	ca	ca	PROPN
fnp-2911	46	25	,	,	PUNCT
fnp-2911	46	26	usa	usa	PROPN
fnp-2911	46	27	)	)	PUNCT
fnp-2911	46	28	at	at	ADP
fnp-2911	46	29	20	20	NUM
fnp-2911	46	30	psi	psi	NOUN
fnp-2911	46	31	on	on	ADP
fnp-2911	46	32	100	100	NUM
fnp-2911	46	33	µm	µm	ADP
fnp-2911	46	34	nozzle	nozzle	NOUN
fnp-2911	46	35	.	.	PUNCT
fnp-2911	47	1	rna	rna	NOUN
fnp-2911	47	2	isolation	isolation	NOUN
fnp-2911	47	3	and	and	CCONJ
fnp-2911	47	4	rna	rna	NOUN
fnp-2911	47	5	-	-	PUNCT
fnp-2911	47	6	seq	seq	NOUN
fnp-2911	47	7	library	library	NOUN
fnp-2911	47	8	generation	generation	NOUN
fnp-2911	47	9	isolation	isolation	NOUN
fnp-2911	47	10	and	and	CCONJ
fnp-2911	47	11	library	library	NOUN
fnp-2911	47	12	generation	generation	NOUN
fnp-2911	47	13	was	be	AUX
fnp-2911	47	14	done	do	VERB
fnp-2911	47	15	as	as	ADP
fnp-2911	47	16	previously	previously	ADV
fnp-2911	47	17	described	describe	VERB
fnp-2911	47	18	(	(	PUNCT
fnp-2911	47	19	52	52	NUM
fnp-2911	47	20	)	)	PUNCT
fnp-2911	47	21	.	.	PUNCT
fnp-2911	48	1	briefly	briefly	NOUN
fnp-2911	48	2	,	,	PUNCT
fnp-2911	48	3	rna	rna	PROPN
fnp-2911	48	4	was	be	AUX
fnp-2911	48	5	extracted	extract	VERB
fnp-2911	48	6	using	use	VERB
fnp-2911	48	7	the	the	DET
fnp-2911	48	8	standard	standard	ADJ
fnp-2911	48	9	protocol	protocol	NOUN
fnp-2911	48	10	within	within	ADP
fnp-2911	48	11	the	the	DET
fnp-2911	48	12	allprep	allprep	PROPN
fnp-2911	48	13	dna	dna	PROPN
fnp-2911	48	14	/	/	SYM
fnp-2911	48	15	rna	rna	PROPN
fnp-2911	48	16	micro	micro	PROPN
fnp-2911	48	17	kit	kit	PROPN
fnp-2911	48	18	(	(	PUNCT
fnp-2911	48	19	qiagen	qiagen	PROPN
fnp-2911	48	20	,	,	PUNCT
fnp-2911	48	21	germantown	germantown	PROPN
fnp-2911	48	22	,	,	PUNCT
fnp-2911	48	23	md	md	PROPN
fnp-2911	48	24	,	,	PUNCT
fnp-2911	48	25	usa	usa	PROPN
fnp-2911	48	26	)	)	PUNCT
fnp-2911	48	27	.	.	PUNCT
fnp-2911	49	1	rna	rna	NOUN
fnp-2911	49	2	quality	quality	NOUN
fnp-2911	49	3	from	from	ADP
fnp-2911	49	4	sorted	sorted	ADJ
fnp-2911	49	5	nuclear	nuclear	ADJ
fnp-2911	49	6	rna	rna	NOUN
fnp-2911	49	7	was	be	AUX
fnp-2911	49	8	determined	determine	VERB
fnp-2911	49	9	based	base	VERB
fnp-2911	49	10	on	on	ADP
fnp-2911	49	11	bioanalyzer	bioanalyzer	ADJ
fnp-2911	49	12	picochip	picochip	NOUN
fnp-2911	49	13	analysis	analysis	NOUN
fnp-2911	49	14	(	(	PUNCT
fnp-2911	49	15	agilent	agilent	PROPN
fnp-2911	49	16	,	,	PUNCT
fnp-2911	49	17	santa	santa	PROPN
fnp-2911	49	18	clara	clara	PROPN
fnp-2911	49	19	,	,	PUNCT
fnp-2911	49	20	ca	ca	PROPN
fnp-2911	49	21	,	,	PUNCT
fnp-2911	49	22	usa	usa	PROPN
fnp-2911	49	23	)	)	PUNCT
fnp-2911	49	24	.	.	PUNCT
fnp-2911	50	1	isolated	isolated	ADJ
fnp-2911	50	2	rna	rna	NOUN
fnp-2911	50	3	was	be	AUX
fnp-2911	50	4	amplified	amplify	VERB
fnp-2911	50	5	,	,	PUNCT
fnp-2911	50	6	made	make	VERB
fnp-2911	50	7	into	into	ADP
fnp-2911	50	8	cdna	cdna	PROPN
fnp-2911	50	9	,	,	PUNCT
fnp-2911	50	10	sheared	shear	VERB
fnp-2911	50	11	,	,	PUNCT
fnp-2911	50	12	and	and	CCONJ
fnp-2911	50	13	libraries	library	NOUN
fnp-2911	50	14	were	be	AUX
fnp-2911	50	15	made	make	VERB
fnp-2911	50	16	.	.	PUNCT
fnp-2911	51	1	the	the	DET
fnp-2911	51	2	library	library	NOUN
fnp-2911	51	3	was	be	AUX
fnp-2911	51	4	quantified	quantify	VERB
fnp-2911	51	5	using	use	VERB
fnp-2911	51	6	the	the	DET
fnp-2911	51	7	qubit	qubit	NOUN
fnp-2911	51	8	dsdna	dsdna	NOUN
fnp-2911	51	9	kit	kit	NOUN
fnp-2911	51	10	(	(	PUNCT
fnp-2911	51	11	invitrogen	invitrogen	PROPN
fnp-2911	51	12	)	)	PUNCT
fnp-2911	51	13	and	and	CCONJ
fnp-2911	51	14	kapa	kapa	VERB
fnp-2911	51	15	library	library	ADJ
fnp-2911	51	16	quantification	quantification	NOUN
fnp-2911	51	17	kit	kit	NOUN
fnp-2911	51	18	(	(	PUNCT
fnp-2911	51	19	kapabiosystems	kapabiosystem	NOUN
fnp-2911	51	20	,	,	PUNCT
fnp-2911	51	21	boston	boston	PROPN
fnp-2911	51	22	,	,	PUNCT
fnp-2911	51	23	ma	ma	PROPN
fnp-2911	51	24	)	)	PUNCT
fnp-2911	51	25	.	.	PUNCT
fnp-2911	52	1	cdna	cdna	PROPN
fnp-2911	52	2	libraries	library	NOUN
fnp-2911	52	3	were	be	AUX
fnp-2911	52	4	pooled	pool	VERB
fnp-2911	52	5	,	,	PUNCT
fnp-2911	52	6	clustered	cluster	VERB
fnp-2911	52	7	on	on	ADP
fnp-2911	52	8	the	the	DET
fnp-2911	52	9	cbot	cbot	NOUN
fnp-2911	52	10	and	and	CCONJ
fnp-2911	52	11	subject	subject	ADJ
fnp-2911	52	12	to	to	ADP
fnp-2911	52	13	100	100	NUM
fnp-2911	52	14	or	or	CCONJ
fnp-2911	52	15	125	125	NUM
fnp-2911	52	16	base	base	NOUN
fnp-2911	52	17	pairs	pair	NOUN
fnp-2911	52	18	paired	pair	VERB
fnp-2911	52	19	end	end	NOUN
fnp-2911	52	20	reads	read	VERB
fnp-2911	52	21	on	on	ADP
fnp-2911	52	22	the	the	DET
fnp-2911	52	23	hiseq	hiseq	NOUN
fnp-2911	52	24	2000	2000	NUM
fnp-2911	52	25	or	or	CCONJ
fnp-2911	52	26	2500	2500	NUM
fnp-2911	52	27	(	(	PUNCT
fnp-2911	52	28	illumina	illumina	PROPN
fnp-2911	52	29	,	,	PUNCT
fnp-2911	52	30	san	san	PROPN
fnp-2911	52	31	diego	diego	PROPN
fnp-2911	52	32	,	,	PUNCT
fnp-2911	52	33	ca	ca	PROPN
fnp-2911	52	34	,	,	PUNCT
fnp-2911	52	35	usa	usa	PROPN
fnp-2911	52	36	)	)	PUNCT
fnp-2911	52	37	.	.	PUNCT
fnp-2911	53	1	pre	pre	ADJ
fnp-2911	53	2	-	-	ADJ
fnp-2911	53	3	processing	processing	ADJ
fnp-2911	53	4	,	,	PUNCT
fnp-2911	53	5	mapping	mapping	NOUN
fnp-2911	53	6	and	and	CCONJ
fnp-2911	53	7	filtering	filtering	NOUN
fnp-2911	53	8	of	of	ADP
fnp-2911	53	9	rna	rna	NOUN
fnp-2911	53	10	-	-	PUNCT
fnp-2911	53	11	seq	seq	NOUN
fnp-2911	53	12	data	data	PROPN
fnp-2911	53	13	rna	rna	NOUN
fnp-2911	53	14	-	-	PUNCT
fnp-2911	53	15	seq	seq	NOUN
fnp-2911	53	16	analysis	analysis	NOUN
fnp-2911	53	17	was	be	AUX
fnp-2911	53	18	done	do	VERB
fnp-2911	53	19	as	as	ADP
fnp-2911	53	20	previously	previously	ADV
fnp-2911	53	21	described	describe	VERB
fnp-2911	53	22	(	(	PUNCT
fnp-2911	53	23	52	52	NUM
fnp-2911	53	24	)	)	PUNCT
fnp-2911	53	25	.	.	PUNCT
fnp-2911	54	1	briefly	briefly	NOUN
fnp-2911	54	2	,	,	PUNCT
fnp-2911	54	3	raw	raw	ADJ
fnp-2911	54	4	sequencing	sequencing	NOUN
fnp-2911	54	5	reads	read	NOUN
fnp-2911	54	6	were	be	AUX
fnp-2911	54	7	demultiplexed	demultiplexe	VERB
fnp-2911	54	8	through	through	ADP
fnp-2911	54	9	the	the	DET
fnp-2911	54	10	upenn	upenn	PROPN
fnp-2911	54	11	functional	functional	ADJ
fnp-2911	54	12	genomics	genomic	NOUN
fnp-2911	54	13	core	core	NOUN
fnp-2911	54	14	and	and	CCONJ
fnp-2911	54	15	analyzed	analyze	VERB
fnp-2911	54	16	for	for	ADP
fnp-2911	54	17	quality	quality	NOUN
fnp-2911	54	18	control	control	NOUN
fnp-2911	54	19	using	use	VERB
fnp-2911	54	20	fastqc	fastqc	PROPN
fnp-2911	54	21	.	.	PUNCT
fnp-2911	55	1	reads	read	NOUN
fnp-2911	55	2	were	be	AUX
fnp-2911	55	3	mapped	map	VERB
fnp-2911	55	4	to	to	ADP
fnp-2911	55	5	the	the	DET
fnp-2911	55	6	human	human	ADJ
fnp-2911	55	7	genome	genome	NOUN
fnp-2911	55	8	(	(	PUNCT
fnp-2911	55	9	grch38	grch38	NOUN
fnp-2911	55	10	,	,	PUNCT
fnp-2911	55	11	gencode	gencode	VERB
fnp-2911	55	12	release	release	NOUN
fnp-2911	55	13	22	22	NUM
fnp-2911	55	14	)	)	PUNCT
fnp-2911	55	15	using	use	VERB
fnp-2911	55	16	star	star	NOUN
fnp-2911	55	17	and	and	CCONJ
fnp-2911	55	18	only	only	ADV
fnp-2911	55	19	uniquely	uniquely	ADV
fnp-2911	55	20	mapping	mapping	NOUN
fnp-2911	55	21	reads	read	NOUN
fnp-2911	55	22	were	be	AUX
fnp-2911	55	23	selected	select	VERB
fnp-2911	55	24	for	for	ADP
fnp-2911	55	25	further	further	ADJ
fnp-2911	55	26	analysis	analysis	NOUN
fnp-2911	55	27	.	.	PUNCT
fnp-2911	56	1	ribosomal	ribosomal	NOUN
fnp-2911	56	2	and	and	CCONJ
fnp-2911	56	3	mitochondrial	mitochondrial	ADJ
fnp-2911	56	4	reads	read	NOUN
fnp-2911	56	5	were	be	AUX
fnp-2911	56	6	removed	remove	VERB
fnp-2911	56	7	and	and	CCONJ
fnp-2911	56	8	sam	sam	PROPN
fnp-2911	56	9	files	file	NOUN
fnp-2911	56	10	were	be	AUX
fnp-2911	56	11	converted	convert	VERB
fnp-2911	56	12	to	to	PART
fnp-2911	56	13	bam	bam	VERB
fnp-2911	56	14	files	file	NOUN
fnp-2911	56	15	using	use	VERB
fnp-2911	56	16	samtools	samtool	NOUN
fnp-2911	56	17	view	view	NOUN
fnp-2911	56	18	and	and	CCONJ
fnp-2911	56	19	bam	bam	VERB
fnp-2911	56	20	files	file	NOUN
fnp-2911	56	21	were	be	AUX
fnp-2911	56	22	sorted	sort	VERB
fnp-2911	56	23	by	by	ADP
fnp-2911	56	24	coordinate	coordinate	NOUN
fnp-2911	56	25	with	with	ADP
fnp-2911	56	26	samtools	samtool	NOUN
fnp-2911	56	27	sort	sort	PROPN
fnp-2911	56	28	.	.	PUNCT
fnp-2911	57	1	creation	creation	NOUN
fnp-2911	57	2	of	of	ADP
fnp-2911	57	3	non	non	ADJ
fnp-2911	57	4	-	-	ADJ
fnp-2911	57	5	overlapping	overlapping	ADJ
fnp-2911	57	6	gene	gene	NOUN
fnp-2911	57	7	,	,	PUNCT
fnp-2911	57	8	exon	exon	NOUN
fnp-2911	57	9	and	and	CCONJ
fnp-2911	57	10	intron	intron	ADJ
fnp-2911	57	11	annotations	annotation	NOUN
fnp-2911	57	12	annotations	annotation	NOUN
fnp-2911	57	13	were	be	AUX
fnp-2911	57	14	generated	generate	VERB
fnp-2911	57	15	as	as	ADP
fnp-2911	57	16	previously	previously	ADV
fnp-2911	57	17	described	describe	VERB
fnp-2911	57	18	(	(	PUNCT
fnp-2911	57	19	52	52	NUM
fnp-2911	57	20	)	)	PUNCT
fnp-2911	57	21	.	.	PUNCT
fnp-2911	58	1	briefly	briefly	NOUN
fnp-2911	58	2	,	,	PUNCT
fnp-2911	58	3	annotations	annotation	NOUN
fnp-2911	58	4	were	be	AUX
fnp-2911	58	5	based	base	VERB
fnp-2911	58	6	on	on	ADP
fnp-2911	58	7	the	the	DET
fnp-2911	58	8	comprehensive	comprehensive	ADJ
fnp-2911	58	9	gene	gene	NOUN
fnp-2911	58	10	annotation	annotation	NOUN
fnp-2911	58	11	file	file	NOUN
fnp-2911	58	12	of	of	ADP
fnp-2911	58	13	the	the	DET
fnp-2911	58	14	gencode	gencode	NOUN
fnp-2911	58	15	release	release	NOUN
fnp-2911	58	16	22	22	NUM
fnp-2911	58	17	(	(	PUNCT
fnp-2911	58	18	grch38.p2	grch38.p2	NOUN
fnp-2911	58	19	)	)	PUNCT
fnp-2911	58	20	.	.	PUNCT
fnp-2911	59	1	gtf	gtf	PROPN
fnp-2911	59	2	file	file	NOUN
fnp-2911	59	3	was	be	AUX
fnp-2911	59	4	loaded	load	VERB
fnp-2911	59	5	into	into	ADP
fnp-2911	59	6	r	r	NOUN
fnp-2911	59	7	(	(	PUNCT
fnp-2911	59	8	version	version	NOUN
fnp-2911	59	9	3.2.2	3.2.2	NUM
fnp-2911	59	10	;	;	PUNCT
fnp-2911	59	11	r	r	NOUN
fnp-2911	59	12	core	core	NOUN
fnp-2911	59	13	team	team	NOUN
fnp-2911	59	14	(	(	PUNCT
fnp-2911	59	15	2015	2015	NUM
fnp-2911	59	16	):	):	PUNCT
fnp-2911	59	17	“	"	PUNCT
fnp-2911	59	18	r	r	NOUN
fnp-2911	59	19	:	:	PUNCT
fnp-2911	59	20	a	a	DET
fnp-2911	59	21	language	language	NOUN
fnp-2911	59	22	and	and	CCONJ
fnp-2911	59	23	environment	environment	NOUN
fnp-2911	59	24	for	for	ADP
fnp-2911	59	25	statistical	statistical	ADJ
fnp-2911	59	26	computing	computing	NOUN
fnp-2911	59	27	”	"	PUNCT
fnp-2911	59	28	,	,	PUNCT
fnp-2911	59	29	r	r	NOUN
fnp-2911	59	30	foundation	foundation	NOUN
fnp-2911	59	31	for	for	ADP
fnp-2911	59	32	statistical	statistical	ADJ
fnp-2911	59	33	computing	computing	NOUN
fnp-2911	59	34	,	,	PUNCT
fnp-2911	59	35	vienna	vienna	PROPN
fnp-2911	59	36	,	,	PUNCT
fnp-2911	59	37	austria	austria	PROPN
fnp-2911	59	38	)	)	PUNCT
fnp-2911	59	39	and	and	CCONJ
fnp-2911	59	40	converted	convert	VERB
fnp-2911	59	41	into	into	ADP
fnp-2911	59	42	a	a	DET
fnp-2911	59	43	transcriptdb	transcriptdb	NOUN
fnp-2911	59	44	object	object	NOUN
fnp-2911	59	45	.	.	PUNCT
fnp-2911	60	1	from	from	ADP
fnp-2911	60	2	the	the	DET
fnp-2911	60	3	transcriptdb	transcriptdb	NOUN
fnp-2911	60	4	object	object	NOUN
fnp-2911	60	5	,	,	PUNCT
fnp-2911	60	6	all	all	DET
fnp-2911	60	7	annotated	annotate	VERB
fnp-2911	60	8	ensembl	ensembl	NOUN
fnp-2911	60	9	genes	gene	NOUN
fnp-2911	60	10	and	and	CCONJ
fnp-2911	60	11	their	their	PRON
fnp-2911	60	12	exons	exon	NOUN
fnp-2911	60	13	were	be	AUX
fnp-2911	60	14	pulled	pull	VERB
fnp-2911	60	15	out	out	ADP
fnp-2911	60	16	using	use	VERB
fnp-2911	60	17	exonsby	exonsby	ADJ
fnp-2911	60	18	(	(	PUNCT
fnp-2911	60	19	by=”gene	by=”gene	NOUN
fnp-2911	60	20	”	"	PUNCT
fnp-2911	60	21	)	)	PUNCT
fnp-2911	60	22	and	and	CCONJ
fnp-2911	60	23	ensembl	ensembl	PROPN
fnp-2911	60	24	gene	gene	NOUN
fnp-2911	60	25	ids	id	NOUN
fnp-2911	60	26	were	be	AUX
fnp-2911	60	27	replaced	replace	VERB
fnp-2911	60	28	by	by	ADP
fnp-2911	60	29	official	official	ADJ
fnp-2911	60	30	gene	gene	NOUN
fnp-2911	60	31	symbols	symbol	NOUN
fnp-2911	60	32	with	with	ADP
fnp-2911	60	33	biomart	biomart	NOUN
fnp-2911	60	34	(	(	PUNCT
fnp-2911	60	35	version	version	NOUN
fnp-2911	60	36	2.26.1	2.26.1	NUM
fnp-2911	60	37	)	)	PUNCT
fnp-2911	60	38	.	.	PUNCT
fnp-2911	61	1	genes	gene	NOUN
fnp-2911	61	2	and	and	CCONJ
fnp-2911	61	3	introns	intron	NOUN
fnp-2911	61	4	were	be	AUX
fnp-2911	61	5	defined	define	VERB
fnp-2911	61	6	as	as	ADP
fnp-2911	61	7	previously	previously	ADV
fnp-2911	61	8	described	describe	VERB
fnp-2911	61	9	in	in	ADP
fnp-2911	61	10	the	the	DET
fnp-2911	61	11	above	above	ADJ
fnp-2911	61	12	chapter	chapter	NOUN
fnp-2911	61	13	.	.	PUNCT
fnp-2911	62	1	regions	region	NOUN
fnp-2911	62	2	shared	share	VERB
fnp-2911	62	3	by	by	ADP
fnp-2911	62	4	overlapping	overlap	VERB
fnp-2911	62	5	genes	gene	NOUN
fnp-2911	62	6	were	be	AUX
fnp-2911	62	7	removed	remove	VERB
fnp-2911	62	8	to	to	PART
fnp-2911	62	9	count	count	VERB
fnp-2911	62	10	reads	read	NOUN
fnp-2911	62	11	that	that	PRON
fnp-2911	62	12	map	map	VERB
fnp-2911	62	13	to	to	ADP
fnp-2911	62	14	one	one	NUM
fnp-2911	62	15	gene	gene	NOUN
fnp-2911	62	16	or	or	CCONJ
fnp-2911	62	17	to	to	ADP
fnp-2911	62	18	genic	genic	ADJ
fnp-2911	62	19	elements	element	NOUN
fnp-2911	62	20	(	(	PUNCT
fnp-2911	62	21	exon	exon	NOUN
fnp-2911	62	22	or	or	CCONJ
fnp-2911	62	23	intron	intron	NOUN
fnp-2911	62	24	)	)	PUNCT
fnp-2911	62	25	from	from	ADP
fnp-2911	62	26	one	one	NUM
fnp-2911	62	27	gene	gene	NOUN
fnp-2911	62	28	.	.	PUNCT
fnp-2911	63	1	exons	exon	NOUN
fnp-2911	63	2	and	and	CCONJ
fnp-2911	63	3	introns	intron	NOUN
fnp-2911	63	4	annotations	annotation	NOUN
fnp-2911	63	5	were	be	AUX
fnp-2911	63	6	used	use	VERB
fnp-2911	63	7	for	for	ADP
fnp-2911	63	8	subsequent	subsequent	ADJ
fnp-2911	63	9	analyses	analysis	NOUN
fnp-2911	63	10	in	in	ADP
fnp-2911	63	11	the	the	DET
fnp-2911	63	12	r	r	NOUN
fnp-2911	63	13	package	package	NOUN
fnp-2911	63	14	dexseq	dexseq	NOUN
fnp-2911	63	15	(	(	PUNCT
fnp-2911	63	16	1.16.10	1.16.10	NUM
fnp-2911	63	17	)	)	PUNCT
fnp-2911	63	18	.	.	PUNCT
fnp-2911	64	1	differential	differential	ADJ
fnp-2911	64	2	gene	gene	NOUN
fnp-2911	64	3	and	and	CCONJ
fnp-2911	64	4	genic	genic	ADJ
fnp-2911	64	5	element	element	NOUN
fnp-2911	64	6	expression	expression	NOUN
fnp-2911	64	7	analysis	analysis	NOUN
fnp-2911	64	8	the	the	DET
fnp-2911	64	9	genomic	genomic	ADJ
fnp-2911	64	10	annotation	annotation	NOUN
fnp-2911	64	11	used	use	VERB
fnp-2911	64	12	for	for	ADP
fnp-2911	64	13	read	read	NOUN
fnp-2911	64	14	counting	counting	NOUN
fnp-2911	64	15	was	be	AUX
fnp-2911	64	16	done	do	VERB
fnp-2911	64	17	as	as	ADP
fnp-2911	64	18	previously	previously	ADV
fnp-2911	64	19	described	describe	VERB
fnp-2911	64	20	(	(	PUNCT
fnp-2911	64	21	52	52	NUM
fnp-2911	64	22	)	)	PUNCT
fnp-2911	64	23	.	.	PUNCT
fnp-2911	65	1	the	the	DET
fnp-2911	65	2	mapped	map	VERB
fnp-2911	65	3	,	,	PUNCT
fnp-2911	65	4	filtered	filter	VERB
fnp-2911	65	5	rna	rna	NOUN
fnp-2911	65	6	sequencing	sequencing	NOUN
fnp-2911	65	7	reads	read	NOUN
fnp-2911	65	8	were	be	AUX
fnp-2911	65	9	counted	count	VERB
fnp-2911	65	10	using	use	VERB
fnp-2911	65	11	a	a	DET
fnp-2911	65	12	custom	custom	NOUN
fnp-2911	65	13	r	r	NOUN
fnp-2911	65	14	script	script	NOUN
fnp-2911	65	15	including	include	VERB
fnp-2911	65	16	the	the	DET
fnp-2911	65	17	r	r	NOUN
fnp-2911	65	18	packages	package	NOUN
fnp-2911	65	19	rsamtools	rsamtool	NOUN
fnp-2911	65	20	(	(	PUNCT
fnp-2911	65	21	1.22.0	1.22.0	NUM
fnp-2911	65	22	)	)	PUNCT
fnp-2911	65	23	,	,	PUNCT
fnp-2911	65	24	genomicfeatures	genomicfeature	NOUN
fnp-2911	65	25	(	(	PUNCT
fnp-2911	65	26	1.22.8	1.22.8	NUM
fnp-2911	65	27	)	)	PUNCT
fnp-2911	65	28	and	and	CCONJ
fnp-2911	65	29	genomicalignments	genomicalignment	NOUN
fnp-2911	65	30	(	(	PUNCT
fnp-2911	65	31	1.6.3	1.6.3	NUM
fnp-2911	65	32	)	)	PUNCT
fnp-2911	65	33	.	.	PUNCT
fnp-2911	66	1	briefly	briefly	ADV
fnp-2911	66	2	,	,	PUNCT
fnp-2911	66	3	sorted	sort	VERB
fnp-2911	66	4	bam	bam	NOUN
fnp-2911	66	5	files	file	NOUN
fnp-2911	66	6	were	be	AUX
fnp-2911	66	7	loaded	load	VERB
fnp-2911	66	8	into	into	ADP
fnp-2911	66	9	r	r	NOUN
fnp-2911	66	10	(	(	PUNCT
fnp-2911	66	11	3.2.2	3.2.2	NUM
fnp-2911	66	12	)	)	PUNCT
fnp-2911	66	13	and	and	CCONJ
fnp-2911	66	14	the	the	DET
fnp-2911	66	15	number	number	NOUN
fnp-2911	66	16	of	of	ADP
fnp-2911	66	17	reads	read	NOUN
fnp-2911	66	18	mapping	map	VERB
fnp-2911	66	19	to	to	ADP
fnp-2911	66	20	genes	gene	NOUN
fnp-2911	66	21	,	,	PUNCT
fnp-2911	66	22	exons	exon	NOUN
fnp-2911	66	23	or	or	CCONJ
fnp-2911	66	24	introns	intron	NOUN
fnp-2911	66	25	,	,	PUNCT
fnp-2911	66	26	was	be	AUX
fnp-2911	66	27	computed	compute	VERB
fnp-2911	66	28	.	.	PUNCT
fnp-2911	67	1	genes	gene	NOUN
fnp-2911	67	2	were	be	AUX
fnp-2911	67	3	analyzed	analyze	VERB
fnp-2911	67	4	for	for	ADP
fnp-2911	67	5	differential	differential	ADJ
fnp-2911	67	6	expression	expression	NOUN
fnp-2911	67	7	using	use	VERB
fnp-2911	67	8	the	the	DET
fnp-2911	67	9	r	r	NOUN
fnp-2911	67	10	package	package	NOUN
fnp-2911	67	11	deseq2	deseq2	PROPN
fnp-2911	68	1	(	(	PUNCT
fnp-2911	68	2	1.10.1	1.10.1	NUM
fnp-2911	68	3	)	)	PUNCT
fnp-2911	68	4	.	.	PUNCT
fnp-2911	69	1	analysis	analysis	NOUN
fnp-2911	69	2	was	be	AUX
fnp-2911	69	3	used	use	VERB
fnp-2911	69	4	to	to	PART
fnp-2911	69	5	determine	determine	VERB
fnp-2911	69	6	differences	difference	NOUN
fnp-2911	69	7	between	between	ADP
fnp-2911	69	8	nuclei	nucleus	NOUN
fnp-2911	69	9	from	from	ADP
fnp-2911	69	10	both	both	DET
fnp-2911	69	11	c9orf72	c9orf72	ADJ
fnp-2911	69	12	expansion	expansion	NOUN
fnp-2911	69	13	cases	case	NOUN
fnp-2911	69	14	and	and	CCONJ
fnp-2911	69	15	non	non	ADJ
fnp-2911	69	16	-	-	ADJ
fnp-2911	69	17	diseased	diseased	ADJ
fnp-2911	69	18	controls	control	NOUN
fnp-2911	69	19	(	(	PUNCT
fnp-2911	69	20	option	option	NOUN
fnp-2911	69	21	design=~experiment	design=~experiment	ADJ
fnp-2911	69	22	in	in	ADP
fnp-2911	69	23	deseqdatasetfrommatrix	deseqdatasetfrommatrix	ADJ
fnp-2911	69	24	tool	tool	NOUN
fnp-2911	69	25	where	where	SCONJ
fnp-2911	69	26	experiment	experiment	NOUN
fnp-2911	69	27	is	be	AUX
fnp-2911	69	28	the	the	DET
fnp-2911	69	29	subject	subject	NOUN
fnp-2911	69	30	i	i	PROPN
fnp-2911	69	31	d	d	PROPN
fnp-2911	69	32	)	)	PUNCT
fnp-2911	69	33	.	.	PUNCT
fnp-2911	70	1	sex	sex	NOUN
fnp-2911	70	2	effects	effect	NOUN
fnp-2911	70	3	were	be	AUX
fnp-2911	70	4	removed	remove	VERB
fnp-2911	70	5	with	with	ADP
fnp-2911	70	6	the	the	DET
fnp-2911	70	7	r	r	NOUN
fnp-2911	70	8	package	package	NOUN
fnp-2911	70	9	sva	sva	X
fnp-2911	70	10	(	(	PUNCT
fnp-2911	70	11	3.18.0	3.18.0	NUM
fnp-2911	70	12	)	)	PUNCT
fnp-2911	70	13	according	accord	VERB
fnp-2911	70	14	to	to	ADP
fnp-2911	70	15	the	the	DET
fnp-2911	70	16	deseq2	deseq2	PROPN
fnp-2911	70	17	vignette	vignette	NOUN
fnp-2911	70	18	.	.	PUNCT
fnp-2911	71	1	manual	manual	ADJ
fnp-2911	71	2	annotation	annotation	NOUN
fnp-2911	71	3	of	of	ADP
fnp-2911	71	4	gene	gene	NOUN
fnp-2911	71	5	descriptions	description	NOUN
fnp-2911	71	6	was	be	AUX
fnp-2911	71	7	performed	perform	VERB
fnp-2911	71	8	using	use	VERB
fnp-2911	71	9	gene	gene	NOUN
fnp-2911	71	10	descriptions	description	NOUN
fnp-2911	71	11	on	on	ADP
fnp-2911	71	12	ncbi	ncbi	PROPN
fnp-2911	71	13	.	.	PUNCT
fnp-2911	72	1	differential	differential	PROPN
fnp-2911	72	2	genic	genic	PROPN
fnp-2911	72	3	element	element	NOUN
fnp-2911	72	4	expression	expression	NOUN
fnp-2911	72	5	analysis	analysis	NOUN
fnp-2911	72	6	was	be	AUX
fnp-2911	72	7	done	do	VERB
fnp-2911	72	8	using	use	VERB
fnp-2911	72	9	dexseq	dexseq	NOUN
fnp-2911	72	10	(	(	PUNCT
fnp-2911	72	11	1.16.10	1.16.10	NUM
fnp-2911	72	12	)	)	PUNCT
fnp-2911	72	13	.	.	PUNCT
fnp-2911	73	1	briefly	briefly	NOUN
fnp-2911	73	2	,	,	PUNCT
fnp-2911	73	3	the	the	DET
fnp-2911	73	4	sorted	sort	VERB
fnp-2911	73	5	bam	bam	NOUN
fnp-2911	73	6	files	file	NOUN
fnp-2911	73	7	were	be	AUX
fnp-2911	73	8	used	use	VERB
fnp-2911	73	9	to	to	PART
fnp-2911	73	10	count	count	VERB
fnp-2911	73	11	the	the	DET
fnp-2911	73	12	number	number	NOUN
fnp-2911	73	13	of	of	ADP
fnp-2911	73	14	reads	read	NOUN
fnp-2911	73	15	mapping	map	VERB
fnp-2911	73	16	to	to	ADP
fnp-2911	73	17	exons	exon	NOUN
fnp-2911	73	18	and	and	CCONJ
fnp-2911	73	19	introns	intron	NOUN
fnp-2911	73	20	using	use	VERB
fnp-2911	73	21	the	the	DET
fnp-2911	73	22	exon	exon	NOUN
fnp-2911	73	23	and	and	CCONJ
fnp-2911	73	24	intron	intron	ADJ
fnp-2911	73	25	annotation	annotation	NOUN
fnp-2911	73	26	generated	generate	VERB
fnp-2911	73	27	above	above	ADV
fnp-2911	73	28	and	and	CCONJ
fnp-2911	73	29	computed	compute	VERB
fnp-2911	73	30	using	use	VERB
fnp-2911	73	31	findoverlaps	findoverlap	NOUN
fnp-2911	73	32	and	and	CCONJ
fnp-2911	73	33	countsubjecthits	countsubjecthit	NOUN
fnp-2911	73	34	.	.	PUNCT
fnp-2911	74	1	reads	read	VERB
fnp-2911	74	2	mapping	map	VERB
fnp-2911	74	3	to	to	ADP
fnp-2911	74	4	exon	exon	NOUN
fnp-2911	74	5	-	-	PUNCT
fnp-2911	74	6	intron	intron	NOUN
fnp-2911	74	7	junctions	junction	NOUN
fnp-2911	74	8	were	be	AUX
fnp-2911	74	9	excluded	exclude	VERB
fnp-2911	74	10	.	.	PUNCT
fnp-2911	75	1	sex	sex	NOUN
fnp-2911	75	2	was	be	AUX
fnp-2911	75	3	controlled	control	VERB
fnp-2911	75	4	for	for	ADP
fnp-2911	75	5	by	by	ADP
fnp-2911	75	6	including	include	VERB
fnp-2911	75	7	it	it	PRON
fnp-2911	75	8	in	in	ADP
fnp-2911	75	9	the	the	DET
fnp-2911	75	10	linear	linear	ADJ
fnp-2911	75	11	model	model	NOUN
fnp-2911	75	12	used	use	VERB
fnp-2911	75	13	in	in	ADP
fnp-2911	75	14	the	the	DET
fnp-2911	75	15	analysis	analysis	NOUN
fnp-2911	75	16	by	by	ADP
fnp-2911	75	17	adding	add	VERB
fnp-2911	75	18	the	the	DET
fnp-2911	75	19	term	term	NOUN
fnp-2911	75	20	“	"	PUNCT
fnp-2911	75	21	sex	sex	NOUN
fnp-2911	75	22	:	:	PUNCT
fnp-2911	75	23	exon	exon	PROPN
fnp-2911	75	24	”	"	PUNCT
fnp-2911	75	25	.	.	PUNCT
fnp-2911	76	1	the	the	DET
fnp-2911	76	2	following	follow	VERB
fnp-2911	76	3	linear	linear	NOUN
fnp-2911	76	4	models	model	NOUN
fnp-2911	76	5	were	be	AUX
fnp-2911	76	6	used	use	VERB
fnp-2911	76	7	full	full	ADJ
fnp-2911	76	8	model	model	NOUN
fnp-2911	76	9	=	=	PUNCT
fnp-2911	76	10	~sample	~sample	PUNCT
fnp-2911	76	11	+	+	CCONJ
fnp-2911	76	12	exon	exon	NOUN
fnp-2911	76	13	+	+	CCONJ
fnp-2911	76	14	sex	sex	NOUN
fnp-2911	76	15	:	:	PUNCT
fnp-2911	76	16	exon	exon	NOUN
fnp-2911	76	17	+	+	CCONJ
fnp-2911	76	18	experiment	experiment	NOUN
fnp-2911	76	19	:	:	PUNCT
fnp-2911	76	20	exon	exon	NOUN
fnp-2911	76	21	and	and	CCONJ
fnp-2911	76	22	reduced	reduced	ADJ
fnp-2911	76	23	model	model	NOUN
fnp-2911	76	24	=	=	PUNCT
fnp-2911	76	25	~sample	~sample	PUNCT
fnp-2911	76	26	+	+	CCONJ
fnp-2911	76	27	exon	exon	NOUN
fnp-2911	76	28	+	+	CCONJ
fnp-2911	76	29	sex	sex	NOUN
fnp-2911	76	30	:	:	PUNCT
fnp-2911	76	31	exon	exon	NOUN
fnp-2911	76	32	+	+	CCONJ
fnp-2911	76	33	experiment	experiment	NOUN
fnp-2911	76	34	:	:	PUNCT
fnp-2911	76	35	exon	exon	NOUN
fnp-2911	76	36	and	and	CCONJ
fnp-2911	76	37	reduced	reduced	ADJ
fnp-2911	76	38	model	model	NOUN
fnp-2911	76	39	=	=	PUNCT
fnp-2911	76	40	~sample	~sample	PUNCT
fnp-2911	76	41	+	+	CCONJ
fnp-2911	76	42	exon	exon	NOUN
fnp-2911	76	43	+	+	CCONJ
fnp-2911	76	44	sex	sex	NOUN
fnp-2911	76	45	:	:	PUNCT
fnp-2911	76	46	exon	exon	NOUN
fnp-2911	76	47	,	,	PUNCT
fnp-2911	76	48	where	where	SCONJ
fnp-2911	76	49	sample	sample	NOUN
fnp-2911	76	50	is	be	AUX
fnp-2911	76	51	the	the	DET
fnp-2911	76	52	sample	sample	NOUN
fnp-2911	76	53	i	i	PROPN
fnp-2911	76	54	d	d	PROPN
fnp-2911	76	55	and	and	CCONJ
fnp-2911	76	56	experiment	experiment	VERB
fnp-2911	76	57	the	the	DET
fnp-2911	76	58	subject	subject	NOUN
fnp-2911	77	1	i	i	PRON
fnp-2911	77	2	d.	d.	PROPN
fnp-2911	77	3	in	in	ADP
fnp-2911	77	4	addition	addition	NOUN
fnp-2911	77	5	,	,	PUNCT
fnp-2911	77	6	dispersions	dispersion	NOUN
fnp-2911	77	7	were	be	AUX
fnp-2911	77	8	estimated	estimate	VERB
fnp-2911	77	9	using	use	VERB
fnp-2911	77	10	the	the	DET
fnp-2911	77	11	tool	tool	NOUN
fnp-2911	77	12	estimatedispersions	estimatedispersion	NOUN
fnp-2911	77	13	with	with	ADP
fnp-2911	77	14	option	option	NOUN
fnp-2911	77	15	fittype=’local	fittype=’local	NOUN
fnp-2911	77	16	’	'	PUNCT
fnp-2911	77	17	.	.	PUNCT
fnp-2911	78	1	changes	change	NOUN
fnp-2911	78	2	in	in	ADP
fnp-2911	78	3	expression	expression	NOUN
fnp-2911	78	4	were	be	AUX
fnp-2911	78	5	significant	significant	ADJ
fnp-2911	78	6	if	if	SCONJ
fnp-2911	78	7	bonferroni	bonferroni	NOUN
fnp-2911	78	8	-	-	PUNCT
fnp-2911	78	9	hochberg	hochberg	PROPN
fnp-2911	78	10	multiple	multiple	ADJ
fnp-2911	78	11	testing	testing	NOUN
fnp-2911	78	12	adjusted	adjust	VERB
fnp-2911	78	13	p	p	NOUN
fnp-2911	78	14	-	-	PUNCT
fnp-2911	78	15	values	value	NOUN
fnp-2911	78	16	were	be	AUX
fnp-2911	78	17	less	less	ADJ
fnp-2911	78	18	than	than	ADP
fnp-2911	78	19	0.05	0.05	NUM
fnp-2911	78	20	.	.	PUNCT
fnp-2911	79	1	alternative	alternative	ADJ
fnp-2911	79	2	splicing	splicing	NOUN
fnp-2911	79	3	analysis	analysis	NOUN
fnp-2911	79	4	splicing	splicing	NOUN
fnp-2911	79	5	analysis	analysis	NOUN
fnp-2911	79	6	was	be	AUX
fnp-2911	79	7	performed	perform	VERB
fnp-2911	79	8	as	as	ADP
fnp-2911	79	9	previously	previously	ADV
fnp-2911	79	10	described	describe	VERB
fnp-2911	79	11	(	(	PUNCT
fnp-2911	79	12	52	52	NUM
fnp-2911	79	13	)	)	PUNCT
fnp-2911	79	14	.	.	PUNCT
fnp-2911	80	1	briefly	briefly	ADV
fnp-2911	80	2	,	,	PUNCT
fnp-2911	80	3	all	all	DET
fnp-2911	80	4	fastq	fastq	ADJ
fnp-2911	80	5	files	file	NOUN
fnp-2911	80	6	were	be	AUX
fnp-2911	80	7	trimmed	trim	VERB
fnp-2911	80	8	to	to	ADP
fnp-2911	80	9	100bp	100bp	NOUN
fnp-2911	80	10	,	,	PUNCT
fnp-2911	80	11	aligned	align	VERB
fnp-2911	80	12	to	to	ADP
fnp-2911	80	13	grch38	grch38	VERB
fnp-2911	80	14	using	use	VERB
fnp-2911	80	15	star	star	NOUN
fnp-2911	80	16	;	;	PUNCT
fnp-2911	80	17	ribosomal	ribosomal	NOUN
fnp-2911	80	18	and	and	CCONJ
fnp-2911	80	19	mitochondrial	mitochondrial	ADJ
fnp-2911	80	20	mapped	map	VERB
fnp-2911	80	21	reads	read	NOUN
fnp-2911	80	22	were	be	AUX
fnp-2911	80	23	removed	remove	VERB
fnp-2911	80	24	.	.	PUNCT
fnp-2911	81	1	sam	sam	PROPN
fnp-2911	81	2	files	file	NOUN
fnp-2911	81	3	were	be	AUX
fnp-2911	81	4	converted	convert	VERB
fnp-2911	81	5	to	to	ADP
fnp-2911	81	6	sorted	sorted	ADJ
fnp-2911	81	7	bam	bam	NOUN
fnp-2911	81	8	files	file	NOUN
fnp-2911	81	9	and	and	CCONJ
fnp-2911	81	10	rmats.3.0.9	rmats.3.0.9	NOUN
fnp-2911	81	11	was	be	AUX
fnp-2911	81	12	run	run	VERB
fnp-2911	81	13	using	use	VERB
fnp-2911	81	14	default	default	NOUN
fnp-2911	81	15	parameters	parameter	NOUN
fnp-2911	81	16	with	with	ADP
fnp-2911	81	17	the	the	DET
fnp-2911	81	18	following	follow	VERB
fnp-2911	81	19	options	option	NOUN
fnp-2911	81	20	(	(	PUNCT
fnp-2911	81	21	-t	-t	X
fnp-2911	81	22	paired	pair	VERB
fnp-2911	81	23	–	–	PUNCT
fnp-2911	81	24	len	len	ADJ
fnp-2911	81	25	100	100	NUM
fnp-2911	81	26	–	–	PUNCT
fnp-2911	81	27	c	c	NOUN
fnp-2911	81	28	0.05	0.05	NUM
fnp-2911	81	29	–	–	PUNCT
fnp-2911	81	30	analysis	analysis	NOUN
fnp-2911	81	31	u	u	NOUN
fnp-2911	81	32	)	)	PUNCT
fnp-2911	81	33	.	.	PUNCT
fnp-2911	82	1	significant	significant	ADJ
fnp-2911	82	2	alternative	alternative	ADJ
fnp-2911	82	3	splicing	splicing	NOUN
fnp-2911	82	4	events	event	NOUN
fnp-2911	82	5	were	be	AUX
fnp-2911	82	6	used	use	VERB
fnp-2911	82	7	if	if	SCONJ
fnp-2911	82	8	bonferroni	bonferroni	NOUN
fnp-2911	82	9	-	-	PUNCT
fnp-2911	82	10	hochberg	hochberg	PROPN
fnp-2911	82	11	multiple	multiple	ADJ
fnp-2911	82	12	testing	testing	NOUN
fnp-2911	82	13	adjusted	adjust	VERB
fnp-2911	82	14	p	p	NOUN
fnp-2911	82	15	-	-	PUNCT
fnp-2911	82	16	values	value	NOUN
fnp-2911	82	17	were	be	AUX
fnp-2911	82	18	less	less	ADJ
fnp-2911	82	19	than	than	ADP
fnp-2911	82	20	0.05	0.05	NUM
fnp-2911	82	21	.	.	PUNCT
fnp-2911	83	1	rna	rna	NOUN
fnp-2911	83	2	binding	bind	VERB
fnp-2911	83	3	protein	protein	NOUN
fnp-2911	83	4	clip	clip	NOUN
fnp-2911	83	5	analysis	analysis	NOUN
fnp-2911	83	6	clip	clip	NOUN
fnp-2911	83	7	analysis	analysis	NOUN
fnp-2911	83	8	was	be	AUX
fnp-2911	83	9	done	do	VERB
fnp-2911	83	10	as	as	ADP
fnp-2911	83	11	previously	previously	ADV
fnp-2911	83	12	described	describe	VERB
fnp-2911	83	13	(	(	PUNCT
fnp-2911	83	14	52	52	NUM
fnp-2911	83	15	)	)	PUNCT
fnp-2911	83	16	using	use	VERB
fnp-2911	83	17	published	publish	VERB
fnp-2911	83	18	tdp-43	tdp-43	NUM
fnp-2911	83	19	iclip	iclip	NOUN
fnp-2911	83	20	data	datum	NOUN
fnp-2911	83	21	from	from	ADP
fnp-2911	83	22	sh	sh	PROPN
fnp-2911	83	23	-	-	PUNCT
fnp-2911	83	24	sy5y	sy5y	PROPN
fnp-2911	83	25	cells	cell	NOUN
fnp-2911	83	26	(	(	PUNCT
fnp-2911	83	27	54	54	NUM
fnp-2911	83	28	)	)	PUNCT
fnp-2911	83	29	and	and	CCONJ
fnp-2911	83	30	hnrnp	hnrnp	PROPN
fnp-2911	83	31	a	a	PRON
fnp-2911	83	32	,	,	PUNCT
fnp-2911	83	33	a2b1	a2b1	PROPN
fnp-2911	83	34	,	,	PUNCT
fnp-2911	83	35	f	f	PROPN
fnp-2911	83	36	,	,	PUNCT
fnp-2911	83	37	m	m	PROPN
fnp-2911	83	38	,	,	PUNCT
fnp-2911	83	39	u	u	NOUN
fnp-2911	83	40	clip	clip	NOUN
fnp-2911	83	41	data	datum	NOUN
fnp-2911	83	42	from	from	ADP
fnp-2911	83	43	hek293	hek293	PROPN
fnp-2911	83	44	cells	cell	NOUN
fnp-2911	83	45	(	(	PUNCT
fnp-2911	83	46	55	55	NUM
fnp-2911	83	47	)	)	PUNCT
fnp-2911	83	48	.	.	PUNCT
fnp-2911	84	1	briefly	briefly	ADV
fnp-2911	84	2	,	,	PUNCT
fnp-2911	84	3	hg18	hg18	PROPN
fnp-2911	84	4	bowtie	bowtie	NOUN
fnp-2911	84	5	files	file	NOUN
fnp-2911	84	6	were	be	AUX
fnp-2911	84	7	converted	convert	VERB
fnp-2911	84	8	to	to	ADP
fnp-2911	84	9	fastq	fastq	ADJ
fnp-2911	84	10	files	file	NOUN
fnp-2911	84	11	,	,	PUNCT
fnp-2911	84	12	and	and	CCONJ
fnp-2911	84	13	aligned	align	VERB
fnp-2911	84	14	to	to	ADP
fnp-2911	84	15	hg38	hg38	PROPN
fnp-2911	84	16	.	.	PUNCT
fnp-2911	85	1	pipeclip	pipeclip	NOUN
fnp-2911	85	2	was	be	AUX
fnp-2911	85	3	run	run	VERB
fnp-2911	85	4	using	use	VERB
fnp-2911	85	5	the	the	DET
fnp-2911	85	6	python	python	NOUN
fnp-2911	85	7	script	script	NOUN
fnp-2911	85	8	.	.	PUNCT
fnp-2911	86	1	using	use	VERB
fnp-2911	86	2	r	r	NOUN
fnp-2911	86	3	,	,	PUNCT
fnp-2911	86	4	the	the	DET
fnp-2911	86	5	“	"	PUNCT
fnp-2911	86	6	genomicranges	genomicrange	NOUN
fnp-2911	86	7	”	"	PUNCT
fnp-2911	86	8	package	package	NOUN
fnp-2911	86	9	with	with	ADP
fnp-2911	86	10	‘	'	PUNCT
fnp-2911	86	11	findoverlaps	findoverlap	NOUN
fnp-2911	86	12	’	'	PUNCT
fnp-2911	86	13	option	option	NOUN
fnp-2911	86	14	was	be	AUX
fnp-2911	86	15	used	use	VERB
fnp-2911	86	16	to	to	PART
fnp-2911	86	17	determine	determine	VERB
fnp-2911	86	18	which	which	DET
fnp-2911	86	19	bins	bin	NOUN
fnp-2911	86	20	had	have	VERB
fnp-2911	86	21	rna	rna	NOUN
fnp-2911	86	22	binding	bind	VERB
fnp-2911	86	23	protein	protein	NOUN
fnp-2911	86	24	sites	site	NOUN
fnp-2911	86	25	.	.	PUNCT
fnp-2911	87	1	chi	chi	ADJ
fnp-2911	87	2	-	-	PUNCT
fnp-2911	87	3	square	square	ADJ
fnp-2911	87	4	analysis	analysis	NOUN
fnp-2911	87	5	was	be	AUX
fnp-2911	87	6	done	do	VERB
fnp-2911	87	7	to	to	PART
fnp-2911	87	8	determine	determine	VERB
fnp-2911	87	9	whether	whether	SCONJ
fnp-2911	87	10	there	there	PRON
fnp-2911	87	11	was	be	VERB
fnp-2911	87	12	a	a	DET
fnp-2911	87	13	significant	significant	ADJ
fnp-2911	87	14	enrichment	enrichment	NOUN
fnp-2911	87	15	of	of	ADP
fnp-2911	87	16	bins	bin	NOUN
fnp-2911	87	17	with	with	ADP
fnp-2911	87	18	rna	rna	NOUN
fnp-2911	87	19	binding	bind	VERB
fnp-2911	87	20	protein	protein	NOUN
fnp-2911	87	21	sites	site	NOUN
fnp-2911	87	22	within	within	ADP
fnp-2911	87	23	the	the	DET
fnp-2911	87	24	significantly	significantly	ADV
fnp-2911	87	25	differentially	differentially	ADV
fnp-2911	87	26	used	use	VERB
fnp-2911	87	27	bins	bin	NOUN
fnp-2911	87	28	linked	link	VERB
fnp-2911	87	29	to	to	ADP
fnp-2911	87	30	the	the	DET
fnp-2911	87	31	c9orf72	c9orf72	PROPN
fnp-2911	87	32	mutation	mutation	NOUN
fnp-2911	87	33	.	.	PUNCT
fnp-2911	88	1	principal	principal	ADJ
fnp-2911	88	2	component	component	NOUN
fnp-2911	88	3	analysis	analysis	NOUN
fnp-2911	88	4	principal	principal	ADJ
fnp-2911	88	5	component	component	NOUN
fnp-2911	88	6	analysis	analysis	NOUN
fnp-2911	88	7	was	be	AUX
fnp-2911	88	8	done	do	VERB
fnp-2911	88	9	using	use	VERB
fnp-2911	88	10	the	the	DET
fnp-2911	88	11	log	log	NOUN
fnp-2911	88	12	transformed	transform	VERB
fnp-2911	88	13	read	read	NOUN
fnp-2911	88	14	count	count	NOUN
fnp-2911	88	15	dataset	dataset	VERB
fnp-2911	88	16	in	in	ADP
fnp-2911	88	17	r	r	NOUN
fnp-2911	88	18	with	with	ADP
fnp-2911	88	19	the	the	DET
fnp-2911	88	20	‘	'	PUNCT
fnp-2911	88	21	stats	stat	NOUN
fnp-2911	88	22	’	'	PUNCT
fnp-2911	88	23	package	package	NOUN
fnp-2911	88	24	and	and	CCONJ
fnp-2911	88	25	‘	'	PUNCT
fnp-2911	88	26	prcomp	prcomp	NOUN
fnp-2911	88	27	’	'	PUNCT
fnp-2911	88	28	function	function	NOUN
fnp-2911	88	29	.	.	PUNCT
fnp-2911	89	1	the	the	DET
fnp-2911	89	2	coordinates	coordinate	NOUN
fnp-2911	89	3	were	be	AUX
fnp-2911	89	4	retrieved	retrieve	VERB
fnp-2911	89	5	and	and	CCONJ
fnp-2911	89	6	used	use	VERB
fnp-2911	89	7	to	to	PART
fnp-2911	89	8	plot	plot	VERB
fnp-2911	89	9	principal	principal	ADJ
fnp-2911	89	10	component	component	NOUN
fnp-2911	89	11	2	2	NUM
fnp-2911	89	12	(	(	PUNCT
fnp-2911	89	13	pc2	pc2	NOUN
fnp-2911	89	14	)	)	PUNCT
fnp-2911	89	15	vs	vs	ADP
fnp-2911	89	16	principal	principal	ADJ
fnp-2911	89	17	component	component	NOUN
fnp-2911	89	18	1	1	NUM
fnp-2911	89	19	.	.	PUNCT
fnp-2911	89	20	to	to	PART
fnp-2911	89	21	determine	determine	VERB
fnp-2911	89	22	the	the	DET
fnp-2911	89	23	relationship	relationship	NOUN
fnp-2911	89	24	between	between	ADP
fnp-2911	89	25	pc2	pc2	NOUN
fnp-2911	89	26	vs	vs	ADP
fnp-2911	89	27	c9orf72	c9orf72	ADJ
fnp-2911	89	28	expression	expression	NOUN
fnp-2911	89	29	,	,	PUNCT
fnp-2911	89	30	the	the	DET
fnp-2911	89	31	coordinates	coordinate	NOUN
fnp-2911	89	32	of	of	ADP
fnp-2911	89	33	pc2	pc2	NOUN
fnp-2911	89	34	for	for	ADP
fnp-2911	89	35	each	each	DET
fnp-2911	89	36	sample	sample	NOUN
fnp-2911	89	37	was	be	AUX
fnp-2911	89	38	plotted	plot	VERB
fnp-2911	89	39	against	against	ADP
fnp-2911	89	40	the	the	DET
fnp-2911	89	41	normalized	normalize	VERB
fnp-2911	89	42	c9orf72	c9orf72	ADJ
fnp-2911	89	43	expression	expression	NOUN
fnp-2911	89	44	calculated	calculate	VERB
fnp-2911	89	45	from	from	ADP
fnp-2911	89	46	deseq2	deseq2	PROPN
fnp-2911	89	47	from	from	ADP
fnp-2911	89	48	each	each	DET
fnp-2911	89	49	sample	sample	NOUN
fnp-2911	89	50	.	.	PUNCT
fnp-2911	90	1	pearson	pearson	PROPN
fnp-2911	90	2	’s	’s	PART
fnp-2911	90	3	correlation	correlation	NOUN
fnp-2911	90	4	was	be	AUX
fnp-2911	90	5	performed	perform	VERB
fnp-2911	90	6	to	to	PART
fnp-2911	90	7	determine	determine	VERB
fnp-2911	90	8	the	the	DET
fnp-2911	90	9	correlation	correlation	NOUN
fnp-2911	90	10	between	between	ADP
fnp-2911	90	11	pc2	pc2	NOUN
fnp-2911	90	12	and	and	CCONJ
fnp-2911	90	13	c9orf72	c9orf72	ADJ
fnp-2911	90	14	expression	expression	NOUN
fnp-2911	90	15	.	.	PUNCT
fnp-2911	91	1	gene	gene	NOUN
fnp-2911	91	2	ontology	ontology	NOUN
fnp-2911	91	3	analysis	analysis	NOUN
fnp-2911	91	4	of	of	ADP
fnp-2911	91	5	the	the	DET
fnp-2911	91	6	top	top	ADJ
fnp-2911	91	7	1	1	NUM
fnp-2911	91	8	%	%	NOUN
fnp-2911	91	9	of	of	ADP
fnp-2911	91	10	all	all	DET
fnp-2911	91	11	genes	gene	NOUN
fnp-2911	91	12	that	that	PRON
fnp-2911	91	13	contribute	contribute	VERB
fnp-2911	91	14	to	to	ADP
fnp-2911	91	15	pc2	pc2	NOUN
fnp-2911	91	16	was	be	AUX
fnp-2911	91	17	done	do	VERB
fnp-2911	91	18	using	use	VERB
fnp-2911	91	19	webgestaldt	webgestaldt	PROPN
fnp-2911	91	20	(	(	PUNCT
fnp-2911	91	21	56	56	NUM
fnp-2911	91	22	)	)	PUNCT
fnp-2911	91	23	with	with	ADP
fnp-2911	91	24	the	the	DET
fnp-2911	91	25	overrepresentation	overrepresentation	NOUN
fnp-2911	91	26	enrichment	enrichment	NOUN
fnp-2911	91	27	analysis	analysis	NOUN
fnp-2911	91	28	using	use	VERB
fnp-2911	91	29	the	the	DET
fnp-2911	91	30	‘	'	PUNCT
fnp-2911	91	31	geneontology	geneontology	NOUN
fnp-2911	91	32	’	'	PUNCT
fnp-2911	91	33	functional	functional	ADJ
fnp-2911	91	34	database	database	NOUN
fnp-2911	91	35	with	with	ADP
fnp-2911	91	36	a	a	DET
fnp-2911	91	37	fdr	fdr	PROPN
fnp-2911	91	38	corrected	correct	VERB
fnp-2911	91	39	significance	significance	NOUN
fnp-2911	91	40	level	level	NOUN
fnp-2911	91	41	<	<	X
fnp-2911	91	42	0.05	0.05	NUM
fnp-2911	91	43	.	.	PUNCT
fnp-2911	91	44	methylation	methylation	NOUN
fnp-2911	91	45	correlation	correlation	NOUN
fnp-2911	91	46	methylation	methylation	NOUN
fnp-2911	91	47	levels	level	NOUN
fnp-2911	91	48	for	for	ADP
fnp-2911	91	49	the	the	DET
fnp-2911	91	50	c9orf72	c9orf72	PROPN
fnp-2911	91	51	promoter	promoter	NOUN
fnp-2911	91	52	in	in	ADP
fnp-2911	91	53	patients	patient	NOUN
fnp-2911	91	54	were	be	AUX
fnp-2911	91	55	determined	determine	VERB
fnp-2911	91	56	as	as	ADP
fnp-2911	91	57	previously	previously	ADV
fnp-2911	91	58	described	describe	VERB
fnp-2911	91	59	(	(	PUNCT
fnp-2911	91	60	45	45	NUM
fnp-2911	91	61	)	)	PUNCT
fnp-2911	91	62	.	.	PUNCT
fnp-2911	92	1	briefly	briefly	ADV
fnp-2911	92	2	,	,	PUNCT
fnp-2911	92	3	genomic	genomic	ADJ
fnp-2911	92	4	dna	dna	NOUN
fnp-2911	92	5	from	from	ADP
fnp-2911	92	6	the	the	DET
fnp-2911	92	7	cerebellum	cerebellum	NOUN
fnp-2911	92	8	was	be	AUX
fnp-2911	92	9	extracted	extract	VERB
fnp-2911	92	10	using	use	VERB
fnp-2911	92	11	the	the	DET
fnp-2911	92	12	qiagen	qiagen	NOUN
fnp-2911	92	13	dneasy	dneasy	NOUN
fnp-2911	92	14	blood	blood	NOUN
fnp-2911	92	15	and	and	CCONJ
fnp-2911	92	16	tissue	tissue	NOUN
fnp-2911	92	17	kit	kit	NOUN
fnp-2911	92	18	and	and	CCONJ
fnp-2911	92	19	subject	subject	NOUN
fnp-2911	92	20	to	to	ADP
fnp-2911	92	21	overnight	overnight	ADJ
fnp-2911	92	22	digestion	digestion	NOUN
fnp-2911	92	23	with	with	ADP
fnp-2911	92	24	hhai	hhai	NOUN
fnp-2911	92	25	and	and	CCONJ
fnp-2911	92	26	haeiii	haeiii	PROPN
fnp-2911	92	27	(	(	PUNCT
fnp-2911	92	28	double	double	ADJ
fnp-2911	92	29	-	-	PUNCT
fnp-2911	92	30	digested	digest	VERB
fnp-2911	92	31	)	)	PUNCT
fnp-2911	92	32	or	or	CCONJ
fnp-2911	92	33	just	just	ADV
fnp-2911	92	34	haeiii	haeiii	VERB
fnp-2911	92	35	(	(	PUNCT
fnp-2911	92	36	mock	mock	ADJ
fnp-2911	92	37	)	)	PUNCT
fnp-2911	92	38	alone	alone	ADV
fnp-2911	92	39	.	.	PUNCT
fnp-2911	93	1	a	a	DET
fnp-2911	93	2	small	small	ADJ
fnp-2911	93	3	aliquot	aliquot	NOUN
fnp-2911	93	4	of	of	ADP
fnp-2911	93	5	dna	dna	PROPN
fnp-2911	93	6	was	be	AUX
fnp-2911	93	7	amplified	amplify	VERB
fnp-2911	93	8	using	use	VERB
fnp-2911	93	9	primers	primer	NOUN
fnp-2911	93	10	flanking	flank	VERB
fnp-2911	93	11	the	the	DET
fnp-2911	93	12	hhai	hhai	PROPN
fnp-2911	93	13	cutsite	cutsite	NOUN
fnp-2911	93	14	within	within	ADP
fnp-2911	93	15	the	the	DET
fnp-2911	93	16	c9orf72	c9orf72	PROPN
fnp-2911	93	17	promoter	promoter	NOUN
fnp-2911	93	18	region	region	NOUN
fnp-2911	93	19	using	use	VERB
fnp-2911	93	20	2x	2x	NUM
fnp-2911	93	21	faststart	faststart	VERB
fnp-2911	93	22	sybr	sybr	PROPN
fnp-2911	93	23	green	green	PROPN
fnp-2911	93	24	master	master	PROPN
fnp-2911	93	25	(	(	PUNCT
fnp-2911	93	26	roche	roche	PROPN
fnp-2911	93	27	)	)	PUNCT
fnp-2911	93	28	on	on	ADP
fnp-2911	93	29	the	the	DET
fnp-2911	93	30	abi	abi	PROPN
fnp-2911	93	31	steponeplus	steponeplus	ADJ
fnp-2911	93	32	machine	machine	NOUN
fnp-2911	93	33	.	.	PUNCT
fnp-2911	94	1	the	the	DET
fnp-2911	94	2	difference	difference	NOUN
fnp-2911	94	3	in	in	ADP
fnp-2911	94	4	cycles	cycle	NOUN
fnp-2911	94	5	to	to	PART
fnp-2911	94	6	threshold	threshold	VERB
fnp-2911	94	7	amplification	amplification	NOUN
fnp-2911	94	8	between	between	ADP
fnp-2911	94	9	double	double	ADJ
fnp-2911	94	10	and	and	CCONJ
fnp-2911	94	11	mock	mock	ADJ
fnp-2911	94	12	digested	digest	VERB
fnp-2911	94	13	dna	dna	PROPN
fnp-2911	94	14	was	be	AUX
fnp-2911	94	15	calculated	calculate	VERB
fnp-2911	94	16	as	as	ADP
fnp-2911	94	17	methylation	methylation	NOUN
fnp-2911	94	18	values	value	NOUN
fnp-2911	94	19	.	.	PUNCT
fnp-2911	95	1	spearman	spearman	NOUN
fnp-2911	95	2	’s	’s	PART
fnp-2911	95	3	correlation	correlation	NOUN
fnp-2911	95	4	was	be	AUX
fnp-2911	95	5	calculated	calculate	VERB
fnp-2911	95	6	using	use	VERB
fnp-2911	95	7	gene	gene	NOUN
fnp-2911	95	8	counts	count	NOUN
fnp-2911	95	9	for	for	ADP
fnp-2911	95	10	each	each	DET
fnp-2911	95	11	gene	gene	NOUN
fnp-2911	95	12	and	and	CCONJ
fnp-2911	95	13	methylation	methylation	NOUN
fnp-2911	95	14	values	value	NOUN
fnp-2911	95	15	for	for	ADP
fnp-2911	95	16	each	each	DET
fnp-2911	95	17	c9orf72	c9orf72	PROPN
fnp-2911	95	18	mutation	mutation	NOUN
fnp-2911	95	19	case	case	NOUN
fnp-2911	95	20	.	.	PUNCT
fnp-2911	96	1	r	r	NOUN
fnp-2911	96	2	package	package	NOUN
fnp-2911	96	3	‘	'	PUNCT
fnp-2911	96	4	lsr	lsr	NOUN
fnp-2911	96	5	’	'	PUNCT
fnp-2911	96	6	with	with	ADP
fnp-2911	96	7	‘	'	PUNCT
fnp-2911	96	8	correlate	correlate	VERB
fnp-2911	96	9	’	'	PUNCT
fnp-2911	96	10	function	function	NOUN
fnp-2911	96	11	(	(	PUNCT
fnp-2911	96	12	with	with	ADP
fnp-2911	96	13	options	option	NOUN
fnp-2911	96	14	corr.method=”spearman	corr.method=”spearman	NOUN
fnp-2911	96	15	”	"	PUNCT
fnp-2911	96	16	and	and	CCONJ
fnp-2911	96	17	p.adjust.method=”fdr	p.adjust.method=”fdr	NOUN
fnp-2911	96	18	”	"	PUNCT
fnp-2911	96	19	)	)	PUNCT
fnp-2911	96	20	using	use	VERB
fnp-2911	96	21	the	the	DET
fnp-2911	96	22	spearman	spearman	NOUN
fnp-2911	96	23	’s	’s	PART
fnp-2911	96	24	correlation	correlation	NOUN
fnp-2911	96	25	and	and	CCONJ
fnp-2911	96	26	fdr	fdr	PROPN
fnp-2911	96	27	adjusted	adjust	VERB
fnp-2911	96	28	p	p	NOUN
fnp-2911	96	29	-	-	PUNCT
fnp-2911	96	30	values	value	NOUN
fnp-2911	96	31	was	be	AUX
fnp-2911	96	32	used	use	VERB
fnp-2911	96	33	.	.	PUNCT
fnp-2911	97	1	only	only	ADV
fnp-2911	97	2	correlations	correlation	NOUN
fnp-2911	97	3	from	from	ADP
fnp-2911	97	4	genes	gene	NOUN
fnp-2911	97	5	with	with	ADP
fnp-2911	97	6	hugo	hugo	PROPN
fnp-2911	97	7	gene	gene	NOUN
fnp-2911	97	8	symbols	symbol	NOUN
fnp-2911	97	9	were	be	AUX
fnp-2911	97	10	calculated	calculate	VERB
fnp-2911	97	11	and	and	CCONJ
fnp-2911	97	12	plotted	plot	VERB
fnp-2911	97	13	against	against	ADP
fnp-2911	97	14	gene	gene	NOUN
fnp-2911	97	15	fold	fold	NOUN
fnp-2911	97	16	change	change	NOUN
fnp-2911	97	17	for	for	ADP
fnp-2911	97	18	each	each	DET
fnp-2911	97	19	gene	gene	NOUN
fnp-2911	97	20	that	that	PRON
fnp-2911	97	21	was	be	AUX
fnp-2911	97	22	calculated	calculate	VERB
fnp-2911	97	23	by	by	ADP
fnp-2911	97	24	deseq2	deseq2	PROPN
fnp-2911	97	25	.	.	PUNCT
fnp-2911	98	1	this	this	PRON
fnp-2911	98	2	was	be	AUX
fnp-2911	98	3	done	do	VERB
fnp-2911	98	4	using	use	VERB
fnp-2911	98	5	both	both	PRON
fnp-2911	98	6	significantly	significantly	ADV
fnp-2911	98	7	differentially	differentially	ADV
fnp-2911	98	8	expressed	express	VERB
fnp-2911	98	9	genes	gene	NOUN
fnp-2911	98	10	linked	link	VERB
fnp-2911	98	11	to	to	ADP
fnp-2911	98	12	the	the	DET
fnp-2911	98	13	c9orf72	c9orf72	PROPN
fnp-2911	98	14	mutation	mutation	NOUN
fnp-2911	98	15	(	(	PUNCT
fnp-2911	98	16	deseq2	deseq2	PROPN
fnp-2911	98	17	fdr	fdr	PROPN
fnp-2911	98	18	p	p	NOUN
fnp-2911	98	19	-	-	PUNCT
fnp-2911	98	20	value	value	NOUN
fnp-2911	98	21	<	<	NOUN
fnp-2911	98	22	0.05	0.05	NUM
fnp-2911	98	23	)	)	PUNCT
fnp-2911	98	24	and	and	CCONJ
fnp-2911	98	25	genome	genome	NOUN
fnp-2911	98	26	-	-	PUNCT
fnp-2911	98	27	wide	wide	ADV
fnp-2911	98	28	using	use	VERB
fnp-2911	98	29	all	all	DET
fnp-2911	98	30	expressed	express	VERB
fnp-2911	98	31	genes	gene	NOUN
fnp-2911	98	32	.	.	PUNCT
fnp-2911	99	1	results	result	NOUN
fnp-2911	99	2	fluorescence	fluorescence	VERB
fnp-2911	99	3	activated	activate	VERB
fnp-2911	99	4	cell	cell	NOUN
fnp-2911	99	5	sorting	sorting	NOUN
fnp-2911	99	6	and	and	CCONJ
fnp-2911	99	7	rna	rna	NOUN
fnp-2911	99	8	sequencing	sequencing	NOUN
fnp-2911	99	9	of	of	ADP
fnp-2911	99	10	sorted	sorted	ADJ
fnp-2911	99	11	neuronal	neuronal	ADJ
fnp-2911	99	12	nuclei	nucleus	NOUN
fnp-2911	99	13	the	the	DET
fnp-2911	99	14	c9orf72	c9orf72	PROPN
fnp-2911	99	15	mutation	mutation	NOUN
fnp-2911	99	16	leads	lead	VERB
fnp-2911	99	17	to	to	ADP
fnp-2911	99	18	tdp-43	tdp-43	PROPN
fnp-2911	99	19	pathology	pathology	NOUN
fnp-2911	99	20	which	which	PRON
fnp-2911	99	21	includes	include	VERB
fnp-2911	99	22	the	the	DET
fnp-2911	99	23	formation	formation	NOUN
fnp-2911	99	24	of	of	ADP
fnp-2911	99	25	neuronal	neuronal	ADJ
fnp-2911	99	26	cytoplasmic	cytoplasmic	ADJ
fnp-2911	99	27	inclusions	inclusion	NOUN
fnp-2911	99	28	and	and	CCONJ
fnp-2911	99	29	the	the	DET
fnp-2911	99	30	loss	loss	NOUN
fnp-2911	99	31	of	of	ADP
fnp-2911	99	32	normal	normal	ADJ
fnp-2911	99	33	physiologic	physiologic	ADJ
fnp-2911	99	34	nuclear	nuclear	ADJ
fnp-2911	99	35	tdp-43	tdp-43	PROPN
fnp-2911	99	36	protein	protein	NOUN
fnp-2911	99	37	.	.	PUNCT
fnp-2911	100	1	we	we	PRON
fnp-2911	100	2	have	have	AUX
fnp-2911	100	3	previously	previously	ADV
fnp-2911	100	4	shown	show	VERB
fnp-2911	100	5	that	that	SCONJ
fnp-2911	100	6	the	the	DET
fnp-2911	100	7	loss	loss	NOUN
fnp-2911	100	8	of	of	ADP
fnp-2911	100	9	normal	normal	ADJ
fnp-2911	100	10	nuclear	nuclear	ADJ
fnp-2911	100	11	tdp-43	tdp-43	NOUN
fnp-2911	100	12	protein	protein	NOUN
fnp-2911	100	13	has	have	VERB
fnp-2911	100	14	large	large	ADJ
fnp-2911	100	15	effects	effect	NOUN
fnp-2911	100	16	on	on	ADP
fnp-2911	100	17	the	the	DET
fnp-2911	100	18	nuclear	nuclear	ADJ
fnp-2911	100	19	transcriptome	transcriptome	NOUN
fnp-2911	100	20	(	(	PUNCT
fnp-2911	100	21	52	52	NUM
fnp-2911	100	22	)	)	PUNCT
fnp-2911	100	23	.	.	PUNCT
fnp-2911	101	1	to	to	PART
fnp-2911	101	2	determine	determine	VERB
fnp-2911	101	3	whether	whether	SCONJ
fnp-2911	101	4	the	the	DET
fnp-2911	101	5	c9orf72	c9orf72	PROPN
fnp-2911	101	6	mutation	mutation	NOUN
fnp-2911	101	7	leads	lead	VERB
fnp-2911	101	8	to	to	ADP
fnp-2911	101	9	transcriptomic	transcriptomic	ADJ
fnp-2911	101	10	alterations	alteration	NOUN
fnp-2911	101	11	independent	independent	ADJ
fnp-2911	101	12	of	of	ADP
fnp-2911	101	13	tdp-43	tdp-43	PROPN
fnp-2911	101	14	pathology	pathology	PROPN
fnp-2911	101	15	,	,	PUNCT
fnp-2911	101	16	we	we	PRON
fnp-2911	101	17	isolated	isolate	VERB
fnp-2911	101	18	neuronal	neuronal	ADJ
fnp-2911	101	19	nuclei	nucleus	NOUN
fnp-2911	101	20	with	with	ADP
fnp-2911	101	21	intact	intact	ADJ
fnp-2911	101	22	tdp-43	tdp-43	NOUN
fnp-2911	101	23	expression	expression	NOUN
fnp-2911	101	24	.	.	PUNCT
fnp-2911	102	1	mid	mid	ADJ
fnp-2911	102	2	-	-	ADJ
fnp-2911	102	3	frontal	frontal	ADJ
fnp-2911	102	4	neocortex	neocortex	NOUN
fnp-2911	102	5	from	from	ADP
fnp-2911	102	6	7	7	NUM
fnp-2911	102	7	post	post	ADJ
fnp-2911	102	8	-	-	ADJ
fnp-2911	102	9	mortem	mortem	ADJ
fnp-2911	102	10	c9orf72	c9orf72	ADJ
fnp-2911	102	11	expansion	expansion	NOUN
fnp-2911	102	12	carriers	carrier	NOUN
fnp-2911	102	13	and	and	CCONJ
fnp-2911	102	14	6	6	NUM
fnp-2911	102	15	neurologically	neurologically	ADV
fnp-2911	102	16	normal	normal	ADJ
fnp-2911	102	17	controls	control	NOUN
fnp-2911	102	18	were	be	AUX
fnp-2911	102	19	used	use	VERB
fnp-2911	102	20	to	to	PART
fnp-2911	102	21	isolate	isolate	VERB
fnp-2911	102	22	nuclei	nucleus	NOUN
fnp-2911	102	23	for	for	ADP
fnp-2911	102	24	transcriptome	transcriptome	NOUN
fnp-2911	102	25	-	-	PUNCT
fnp-2911	102	26	wide	wide	ADJ
fnp-2911	102	27	analysis	analysis	NOUN
fnp-2911	102	28	.	.	PUNCT
fnp-2911	103	1	the	the	DET
fnp-2911	103	2	autopsy	autopsy	ADJ
fnp-2911	103	3	cohort	cohort	NOUN
fnp-2911	103	4	characteristics	characteristic	NOUN
fnp-2911	103	5	can	can	AUX
fnp-2911	103	6	be	be	AUX
fnp-2911	103	7	found	find	VERB
fnp-2911	103	8	in	in	ADP
fnp-2911	103	9	table	table	NOUN
fnp-2911	103	10	1	1	NUM
fnp-2911	103	11	.	.	PUNCT
fnp-2911	104	1	nuclei	nucleus	NOUN
fnp-2911	104	2	were	be	AUX
fnp-2911	104	3	immunostained	immunostaine	VERB
fnp-2911	104	4	for	for	ADP
fnp-2911	104	5	neun	neun	NOUN
fnp-2911	104	6	and	and	CCONJ
fnp-2911	104	7	tdp-43	tdp-43	NOUN
fnp-2911	104	8	and	and	CCONJ
fnp-2911	104	9	subjected	subject	VERB
fnp-2911	104	10	to	to	ADP
fnp-2911	104	11	fac	fac	PROPN
fnp-2911	104	12	sorting	sort	VERB
fnp-2911	104	13	to	to	PART
fnp-2911	104	14	isolate	isolate	VERB
fnp-2911	104	15	neun	neun	NOUN
fnp-2911	104	16	positive	positive	ADJ
fnp-2911	104	17	,	,	PUNCT
fnp-2911	104	18	tdp-43	tdp-43	X
fnp-2911	104	19	positive	positive	ADJ
fnp-2911	104	20	nuclei	nucleus	NOUN
fnp-2911	104	21	from	from	ADP
fnp-2911	104	22	controls	control	NOUN
fnp-2911	104	23	(	(	PUNCT
fnp-2911	104	24	circled	circle	VERB
fnp-2911	104	25	,	,	PUNCT
fnp-2911	104	26	fig	fig	NOUN
fnp-2911	104	27	1a	1a	NOUN
fnp-2911	104	28	)	)	PUNCT
fnp-2911	104	29	and	and	CCONJ
fnp-2911	104	30	c9orf72	c9orf72	ADJ
fnp-2911	104	31	expansion	expansion	NOUN
fnp-2911	104	32	cases	case	NOUN
fnp-2911	104	33	(	(	PUNCT
fnp-2911	104	34	circled	circle	VERB
fnp-2911	104	35	,	,	PUNCT
fnp-2911	104	36	fig	fig	NOUN
fnp-2911	104	37	1b	1b	NUM
fnp-2911	104	38	)	)	PUNCT
fnp-2911	104	39	.	.	PUNCT
fnp-2911	105	1	rna	rna	NOUN
fnp-2911	105	2	from	from	ADP
fnp-2911	105	3	equal	equal	ADJ
fnp-2911	105	4	numbers	number	NOUN
fnp-2911	105	5	of	of	ADP
fnp-2911	105	6	tdp-43	tdp-43	NOUN
fnp-2911	105	7	positive	positive	ADJ
fnp-2911	105	8	neuronal	neuronal	ADJ
fnp-2911	105	9	nuclei	nucleus	NOUN
fnp-2911	105	10	(	(	PUNCT
fnp-2911	105	11	35,000	35,000	NUM
fnp-2911	105	12	-	-	SYM
fnp-2911	105	13	100,000	100,000	NUM
fnp-2911	105	14	)	)	PUNCT
fnp-2911	105	15	was	be	AUX
fnp-2911	105	16	extracted	extract	VERB
fnp-2911	105	17	and	and	CCONJ
fnp-2911	105	18	amplified	amplify	VERB
fnp-2911	105	19	to	to	PART
fnp-2911	105	20	generate	generate	VERB
fnp-2911	105	21	barcoded	barcode	VERB
fnp-2911	105	22	cdna	cdna	PROPN
fnp-2911	105	23	libraries	library	NOUN
fnp-2911	105	24	for	for	ADP
fnp-2911	105	25	100	100	NUM
fnp-2911	105	26	or	or	CCONJ
fnp-2911	105	27	125bp	125bp	NOUN
fnp-2911	105	28	paired	pair	VERB
fnp-2911	105	29	end	end	NOUN
fnp-2911	105	30	sequencing	sequence	VERB
fnp-2911	105	31	on	on	ADP
fnp-2911	105	32	the	the	DET
fnp-2911	105	33	illumina	illumina	PROPN
fnp-2911	105	34	hiseq	hiseq	PROPN
fnp-2911	105	35	2000/2500	2000/2500	NUM
fnp-2911	105	36	.	.	PUNCT
fnp-2911	106	1	sequences	sequence	NOUN
fnp-2911	106	2	were	be	AUX
fnp-2911	106	3	mapped	map	VERB
fnp-2911	106	4	to	to	ADP
fnp-2911	106	5	the	the	DET
fnp-2911	106	6	human	human	ADJ
fnp-2911	106	7	genome	genome	NOUN
fnp-2911	106	8	(	(	PUNCT
fnp-2911	106	9	gencode	gencode	PROPN
fnp-2911	106	10	grch38	grch38	NOUN
fnp-2911	106	11	)	)	PUNCT
fnp-2911	106	12	using	use	VERB
fnp-2911	106	13	star	star	NOUN
fnp-2911	106	14	algorithms	algorithm	NOUN
fnp-2911	106	15	(	(	PUNCT
fnp-2911	106	16	version	version	NOUN
fnp-2911	106	17	2.2.4	2.2.4	NUM
fnp-2911	106	18	)	)	PUNCT
fnp-2911	106	19	.	.	PUNCT
fnp-2911	107	1	there	there	PRON
fnp-2911	107	2	were	be	VERB
fnp-2911	107	3	1.8	1.8	NUM
fnp-2911	107	4	billion	billion	NUM
fnp-2911	107	5	reads	read	NOUN
fnp-2911	107	6	of	of	ADP
fnp-2911	107	7	which	which	PRON
fnp-2911	107	8	1.065	1.065	NUM
fnp-2911	107	9	billion	billion	NUM
fnp-2911	107	10	reads	read	NOUN
fnp-2911	107	11	mapped	map	VERB
fnp-2911	107	12	uniquely	uniquely	ADV
fnp-2911	107	13	between	between	ADP
fnp-2911	107	14	the	the	DET
fnp-2911	107	15	13	13	NUM
fnp-2911	107	16	libraries	library	NOUN
fnp-2911	107	17	,	,	PUNCT
fnp-2911	107	18	with	with	ADP
fnp-2911	107	19	an	an	DET
fnp-2911	107	20	average	average	NOUN
fnp-2911	107	21	of	of	ADP
fnp-2911	107	22	90	90	NUM
fnp-2911	107	23	million	million	NUM
fnp-2911	107	24	uniquely	uniquely	ADV
fnp-2911	107	25	mapped	map	VERB
fnp-2911	107	26	reads	read	NOUN
fnp-2911	107	27	per	per	ADP
fnp-2911	107	28	library	library	NOUN
fnp-2911	107	29	.	.	PUNCT
fnp-2911	108	1	these	these	DET
fnp-2911	108	2	reads	read	NOUN
fnp-2911	108	3	were	be	AUX
fnp-2911	108	4	filtered	filter	VERB
fnp-2911	108	5	to	to	PART
fnp-2911	108	6	remove	remove	VERB
fnp-2911	108	7	ribosomal	ribosomal	NOUN
fnp-2911	108	8	and	and	CCONJ
fnp-2911	108	9	mitochondrial	mitochondrial	ADJ
fnp-2911	108	10	reads	read	NOUN
fnp-2911	108	11	and	and	CCONJ
fnp-2911	108	12	the	the	DET
fnp-2911	108	13	resulting	result	VERB
fnp-2911	108	14	reads	read	NOUN
fnp-2911	108	15	were	be	AUX
fnp-2911	108	16	used	use	VERB
fnp-2911	108	17	for	for	ADP
fnp-2911	108	18	downstream	downstream	ADJ
fnp-2911	108	19	analysis	analysis	NOUN
fnp-2911	108	20	to	to	PART
fnp-2911	108	21	evaluate	evaluate	VERB
fnp-2911	108	22	differential	differential	ADJ
fnp-2911	108	23	expression	expression	NOUN
fnp-2911	108	24	of	of	ADP
fnp-2911	108	25	genes	gene	NOUN
fnp-2911	108	26	,	,	PUNCT
fnp-2911	108	27	genic	genic	ADJ
fnp-2911	108	28	elements	element	NOUN
fnp-2911	108	29	and	and	CCONJ
fnp-2911	108	30	alternative	alternative	ADJ
fnp-2911	108	31	splicing	splicing	NOUN
fnp-2911	108	32	.	.	PUNCT
fnp-2911	109	1	table	table	NOUN
fnp-2911	109	2	1	1	NUM
fnp-2911	109	3	:	:	PUNCT
fnp-2911	109	4	autopsy	autopsy	ADJ
fnp-2911	109	5	cohort	cohort	NOUN
fnp-2911	109	6	characteristics	characteristic	NOUN
fnp-2911	109	7	.	.	PUNCT
fnp-2911	110	1	als	als	NOUN
fnp-2911	110	2	=	=	SYM
fnp-2911	110	3	amyotrophic	amyotrophic	ADJ
fnp-2911	110	4	lateral	lateral	ADJ
fnp-2911	110	5	sclerosis	sclerosis	NOUN
fnp-2911	110	6	;	;	PUNCT
fnp-2911	110	7	ftld	ftld	ADJ
fnp-2911	110	8	=	=	SYM
fnp-2911	110	9	frontotemporal	frontotemporal	ADJ
fnp-2911	110	10	lobar	lobar	ADJ
fnp-2911	110	11	degeneration	degeneration	NOUN
fnp-2911	110	12	with	with	ADP
fnp-2911	110	13	tdp-43	tdp-43	NOUN
fnp-2911	110	14	inclusions	inclusion	NOUN
fnp-2911	110	15	;	;	PUNCT
fnp-2911	110	16	mnd	mnd	PROPN
fnp-2911	110	17	=	=	SYM
fnp-2911	110	18	motor	motor	NOUN
fnp-2911	110	19	neuron	neuron	NOUN
fnp-2911	110	20	disease	disease	NOUN
fnp-2911	110	21	;	;	PUNCT
fnp-2911	110	22	nl	nl	PROPN
fnp-2911	110	23	=	=	SYM
fnp-2911	110	24	normal	normal	ADJ
fnp-2911	110	25	;	;	PUNCT
fnp-2911	110	26	pmi	pmi	PROPN
fnp-2911	110	27	=	=	PUNCT
fnp-2911	110	28	post	post	ADJ
fnp-2911	110	29	-	-	ADJ
fnp-2911	110	30	mortem	mortem	ADJ
fnp-2911	110	31	interval	interval	NOUN
fnp-2911	110	32	;	;	PUNCT
fnp-2911	110	33	rin	rin	NOUN
fnp-2911	110	34	=	=	PROPN
fnp-2911	110	35	rna	rna	NOUN
fnp-2911	110	36	integrity	integrity	NOUN
fnp-2911	110	37	number	number	NOUN
fnp-2911	110	38	fig	fig	NOUN
fnp-2911	110	39	1	1	NUM
fnp-2911	110	40	:	:	PUNCT
fnp-2911	110	41	c9orf72	c9orf72	PROPN
fnp-2911	110	42	repeat	repeat	NOUN
fnp-2911	110	43	expansion	expansion	NOUN
fnp-2911	110	44	contributes	contribute	VERB
fnp-2911	110	45	to	to	ADP
fnp-2911	110	46	relatively	relatively	ADV
fnp-2911	110	47	mild	mild	ADJ
fnp-2911	110	48	transcriptome	transcriptome	ADJ
fnp-2911	110	49	changes	change	NOUN
fnp-2911	110	50	.	.	PUNCT
fnp-2911	111	1	flow	flow	NOUN
fnp-2911	111	2	cytometry	cytometry	NOUN
fnp-2911	111	3	plots	plot	NOUN
fnp-2911	111	4	of	of	ADP
fnp-2911	111	5	control	control	NOUN
fnp-2911	111	6	(	(	PUNCT
fnp-2911	111	7	a	a	NOUN
fnp-2911	111	8	)	)	PUNCT
fnp-2911	111	9	and	and	CCONJ
fnp-2911	111	10	c9orf72	c9orf72	ADJ
fnp-2911	111	11	expansion	expansion	NOUN
fnp-2911	111	12	cases	case	NOUN
fnp-2911	111	13	(	(	PUNCT
fnp-2911	111	14	b	b	NOUN
fnp-2911	111	15	)	)	PUNCT
fnp-2911	111	16	with	with	ADP
fnp-2911	111	17	tdp-43	tdp-43	NUM
fnp-2911	111	18	positive	positive	ADJ
fnp-2911	111	19	neuronal	neuronal	ADJ
fnp-2911	111	20	nuclei	nucleus	NOUN
fnp-2911	111	21	circled	circle	VERB
fnp-2911	111	22	as	as	ADP
fnp-2911	111	23	collected	collect	VERB
fnp-2911	111	24	samples	sample	NOUN
fnp-2911	111	25	.	.	PUNCT
fnp-2911	112	1	(	(	PUNCT
fnp-2911	112	2	c	c	X
fnp-2911	112	3	)	)	PUNCT
fnp-2911	112	4	principal	principal	ADJ
fnp-2911	112	5	component	component	NOUN
fnp-2911	112	6	analysis	analysis	NOUN
fnp-2911	112	7	using	use	VERB
fnp-2911	112	8	all	all	DET
fnp-2911	112	9	expressed	express	VERB
fnp-2911	112	10	genes	gene	NOUN
fnp-2911	112	11	where	where	SCONJ
fnp-2911	112	12	shape	shape	NOUN
fnp-2911	112	13	denotes	denote	VERB
fnp-2911	112	14	sex	sex	NOUN
fnp-2911	112	15	and	and	CCONJ
fnp-2911	112	16	color	color	NOUN
fnp-2911	112	17	denotes	denote	NOUN
fnp-2911	112	18	condition	condition	NOUN
fnp-2911	112	19	.	.	PUNCT
fnp-2911	113	1	(	(	PUNCT
fnp-2911	113	2	d	d	X
fnp-2911	113	3	)	)	PUNCT
fnp-2911	113	4	principal	principal	ADJ
fnp-2911	113	5	component	component	NOUN
fnp-2911	113	6	2	2	NUM
fnp-2911	113	7	strongly	strongly	ADV
fnp-2911	113	8	correlates	correlate	VERB
fnp-2911	113	9	with	with	ADP
fnp-2911	113	10	c9orf72	c9orf72	ADJ
fnp-2911	113	11	expression	expression	NOUN
fnp-2911	113	12	(	(	PUNCT
fnp-2911	113	13	pearson	pearson	PROPN
fnp-2911	113	14	’s	’s	PART
fnp-2911	113	15	r	r	NOUN
fnp-2911	113	16	=	=	SYM
fnp-2911	113	17	-0.8205	-0.8205	X
fnp-2911	113	18	;	;	PUNCT
fnp-2911	113	19	p=0.0006	p=0.0006	NUM
fnp-2911	113	20	)	)	PUNCT
fnp-2911	113	21	.	.	PUNCT
fnp-2911	114	1	(	(	PUNCT
fnp-2911	114	2	e	e	X
fnp-2911	114	3	)	)	PUNCT
fnp-2911	114	4	ma	ma	PROPN
fnp-2911	114	5	plot	plot	NOUN
fnp-2911	114	6	showing	show	VERB
fnp-2911	114	7	gene	gene	NOUN
fnp-2911	114	8	fold	fold	NOUN
fnp-2911	114	9	change	change	NOUN
fnp-2911	114	10	as	as	ADP
fnp-2911	114	11	a	a	DET
fnp-2911	114	12	function	function	NOUN
fnp-2911	114	13	of	of	ADP
fnp-2911	114	14	mean	mean	NOUN
fnp-2911	114	15	normalized	normalize	VERB
fnp-2911	114	16	gene	gene	NOUN
fnp-2911	114	17	counts	count	NOUN
fnp-2911	114	18	with	with	ADP
fnp-2911	114	19	red	red	ADJ
fnp-2911	114	20	dots	dot	NOUN
fnp-2911	114	21	being	be	AUX
fnp-2911	114	22	significantly	significantly	ADV
fnp-2911	114	23	differentially	differentially	ADV
fnp-2911	114	24	expressed	express	VERB
fnp-2911	114	25	genes	gene	NOUN
fnp-2911	114	26	.	.	PUNCT
fnp-2911	115	1	(	(	PUNCT
fnp-2911	115	2	f	f	X
fnp-2911	115	3	)	)	PUNCT
fnp-2911	115	4	pie	pie	NOUN
fnp-2911	115	5	chart	chart	NOUN
fnp-2911	115	6	distribution	distribution	NOUN
fnp-2911	115	7	of	of	ADP
fnp-2911	115	8	all	all	DET
fnp-2911	115	9	alternative	alternative	ADJ
fnp-2911	115	10	splicing	splicing	NOUN
fnp-2911	115	11	events	event	NOUN
fnp-2911	115	12	between	between	ADP
fnp-2911	115	13	c9orf72	c9orf72	ADJ
fnp-2911	115	14	expansion	expansion	NOUN
fnp-2911	115	15	carriers	carrier	NOUN
fnp-2911	115	16	and	and	CCONJ
fnp-2911	115	17	non	non	ADJ
fnp-2911	115	18	-	-	ADJ
fnp-2911	115	19	diseased	diseased	ADJ
fnp-2911	115	20	controls	control	NOUN
fnp-2911	115	21	.	.	PUNCT
fnp-2911	116	1	se	se	X
fnp-2911	116	2	=	=	PRON
fnp-2911	116	3	skipped	skip	VERB
fnp-2911	116	4	exons	exon	NOUN
fnp-2911	116	5	,	,	PUNCT
fnp-2911	116	6	mxe	mxe	NOUN
fnp-2911	116	7	=	=	PROPN
fnp-2911	116	8	mutually	mutually	ADV
fnp-2911	116	9	exclusive	exclusive	ADJ
fnp-2911	116	10	exons	exon	NOUN
fnp-2911	116	11	,	,	PUNCT
fnp-2911	116	12	ri	ri	PROPN
fnp-2911	116	13	=	=	PRON
fnp-2911	116	14	retained	retain	VERB
fnp-2911	116	15	intron	intron	NOUN
fnp-2911	116	16	,	,	PUNCT
fnp-2911	116	17	a3ss	a3ss	ADP
fnp-2911	116	18	=	=	NOUN
fnp-2911	116	19	alternative	alternative	ADJ
fnp-2911	116	20	3	3	NUM
fnp-2911	116	21	’	'	PUNCT
fnp-2911	116	22	splice	splice	NOUN
fnp-2911	116	23	site	site	NOUN
fnp-2911	116	24	,	,	PUNCT
fnp-2911	116	25	a5ss	a5ss	X
fnp-2911	116	26	=	=	NOUN
fnp-2911	116	27	alternative	alternative	ADJ
fnp-2911	116	28	5	5	NUM
fnp-2911	116	29	’	'	PUNCT
fnp-2911	116	30	splice	splice	NOUN
fnp-2911	116	31	site	site	NOUN
fnp-2911	116	32	.	.	PUNCT
fnp-2911	117	1	functional	functional	ADJ
fnp-2911	117	2	transcriptomic	transcriptomic	ADJ
fnp-2911	117	3	alterations	alteration	NOUN
fnp-2911	117	4	associated	associate	VERB
fnp-2911	117	5	with	with	ADP
fnp-2911	117	6	the	the	DET
fnp-2911	117	7	c9orf72	c9orf72	PROPN
fnp-2911	117	8	hexanucleotide	hexanucleotide	ADJ
fnp-2911	117	9	repeat	repeat	NOUN
fnp-2911	117	10	expansion	expansion	NOUN
fnp-2911	117	11	to	to	PART
fnp-2911	117	12	verify	verify	VERB
fnp-2911	117	13	that	that	SCONJ
fnp-2911	117	14	the	the	DET
fnp-2911	117	15	variation	variation	NOUN
fnp-2911	117	16	within	within	ADP
fnp-2911	117	17	the	the	DET
fnp-2911	117	18	dataset	dataset	NOUN
fnp-2911	117	19	is	be	AUX
fnp-2911	117	20	linked	link	VERB
fnp-2911	117	21	to	to	ADP
fnp-2911	117	22	the	the	DET
fnp-2911	117	23	mutation	mutation	NOUN
fnp-2911	117	24	status	status	NOUN
fnp-2911	117	25	,	,	PUNCT
fnp-2911	117	26	principal	principal	ADJ
fnp-2911	117	27	component	component	NOUN
fnp-2911	117	28	analysis	analysis	NOUN
fnp-2911	117	29	(	(	PUNCT
fnp-2911	117	30	pca	pca	NOUN
fnp-2911	117	31	)	)	PUNCT
fnp-2911	117	32	was	be	AUX
fnp-2911	117	33	performed	perform	VERB
fnp-2911	117	34	using	use	VERB
fnp-2911	117	35	the	the	DET
fnp-2911	117	36	read	read	NOUN
fnp-2911	117	37	counts	count	NOUN
fnp-2911	117	38	of	of	ADP
fnp-2911	117	39	the	the	DET
fnp-2911	117	40	entire	entire	ADJ
fnp-2911	117	41	dataset	dataset	NOUN
fnp-2911	117	42	(	(	PUNCT
fnp-2911	117	43	fig	fig	NOUN
fnp-2911	117	44	1c	1c	NUM
fnp-2911	117	45	)	)	PUNCT
fnp-2911	117	46	.	.	PUNCT
fnp-2911	118	1	principal	principal	ADJ
fnp-2911	118	2	component	component	NOUN
fnp-2911	118	3	#	#	SYM
fnp-2911	118	4	1	1	NUM
fnp-2911	118	5	(	(	PUNCT
fnp-2911	118	6	pc1	pc1	PROPN
fnp-2911	118	7	)	)	PUNCT
fnp-2911	118	8	explained	explain	VERB
fnp-2911	118	9	21	21	NUM
fnp-2911	118	10	%	%	NOUN
fnp-2911	118	11	of	of	ADP
fnp-2911	118	12	the	the	DET
fnp-2911	118	13	variation	variation	NOUN
fnp-2911	118	14	whereas	whereas	SCONJ
fnp-2911	118	15	pc2	pc2	NOUN
fnp-2911	118	16	explained	explain	VERB
fnp-2911	118	17	19	19	NUM
fnp-2911	118	18	%	%	NOUN
fnp-2911	118	19	of	of	ADP
fnp-2911	118	20	the	the	DET
fnp-2911	118	21	variation	variation	NOUN
fnp-2911	118	22	(	(	PUNCT
fnp-2911	118	23	fig	fig	NOUN
fnp-2911	118	24	1c	1c	NUM
fnp-2911	118	25	)	)	PUNCT
fnp-2911	118	26	.	.	PUNCT
fnp-2911	119	1	based	base	VERB
fnp-2911	119	2	on	on	ADP
fnp-2911	119	3	the	the	DET
fnp-2911	119	4	clustering	clustering	NOUN
fnp-2911	119	5	of	of	ADP
fnp-2911	119	6	the	the	DET
fnp-2911	119	7	dataset	dataset	NOUN
fnp-2911	119	8	,	,	PUNCT
fnp-2911	119	9	sex	sex	NOUN
fnp-2911	119	10	explains	explain	VERB
fnp-2911	119	11	the	the	DET
fnp-2911	119	12	variation	variation	NOUN
fnp-2911	119	13	in	in	ADP
fnp-2911	119	14	pc1	pc1	PROPN
fnp-2911	119	15	while	while	SCONJ
fnp-2911	119	16	the	the	DET
fnp-2911	119	17	c9orf72	c9orf72	PROPN
fnp-2911	119	18	repeat	repeat	NOUN
fnp-2911	119	19	expansion	expansion	NOUN
fnp-2911	119	20	explains	explain	VERB
fnp-2911	119	21	the	the	DET
fnp-2911	119	22	variation	variation	NOUN
fnp-2911	119	23	in	in	ADP
fnp-2911	119	24	pc2	pc2	NOUN
fnp-2911	119	25	.	.	PUNCT
fnp-2911	120	1	indeed	indeed	ADV
fnp-2911	120	2	,	,	PUNCT
fnp-2911	120	3	pc2	pc2	NOUN
fnp-2911	120	4	strongly	strongly	ADV
fnp-2911	120	5	correlated	correlate	VERB
fnp-2911	120	6	with	with	ADP
fnp-2911	120	7	c9orf72	c9orf72	PROPN
fnp-2911	120	8	mrna	mrna	PROPN
fnp-2911	120	9	expression	expression	NOUN
fnp-2911	120	10	(	(	PUNCT
fnp-2911	120	11	pearson	pearson	PROPN
fnp-2911	120	12	’s	’s	PART
fnp-2911	120	13	r=-0.8205	r=-0.8205	NOUN
fnp-2911	120	14	;	;	PUNCT
fnp-2911	120	15	p=0.0006	p=0.0006	PROPN
fnp-2911	120	16	)	)	PUNCT
fnp-2911	120	17	,	,	PUNCT
fnp-2911	120	18	suggesting	suggest	VERB
fnp-2911	120	19	that	that	SCONJ
fnp-2911	120	20	c9orf72	c9orf72	ADJ
fnp-2911	120	21	expression	expression	NOUN
fnp-2911	120	22	is	be	AUX
fnp-2911	120	23	the	the	DET
fnp-2911	120	24	major	major	ADJ
fnp-2911	120	25	underlying	underlying	ADJ
fnp-2911	120	26	biological	biological	ADJ
fnp-2911	120	27	variable	variable	NOUN
fnp-2911	120	28	that	that	PRON
fnp-2911	120	29	contributes	contribute	VERB
fnp-2911	120	30	to	to	ADP
fnp-2911	120	31	the	the	DET
fnp-2911	120	32	variation	variation	NOUN
fnp-2911	120	33	in	in	ADP
fnp-2911	120	34	pc2	pc2	PROPN
fnp-2911	120	35	(	(	PUNCT
fnp-2911	120	36	fig	fig	NOUN
fnp-2911	120	37	1d	1d	NUM
fnp-2911	120	38	)	)	PUNCT
fnp-2911	120	39	.	.	PUNCT
fnp-2911	121	1	to	to	PART
fnp-2911	121	2	identify	identify	VERB
fnp-2911	121	3	whether	whether	SCONJ
fnp-2911	121	4	there	there	PRON
fnp-2911	121	5	were	be	VERB
fnp-2911	121	6	enriched	enrich	VERB
fnp-2911	121	7	pathways	pathway	NOUN
fnp-2911	121	8	within	within	ADP
fnp-2911	121	9	the	the	DET
fnp-2911	121	10	genes	gene	NOUN
fnp-2911	121	11	that	that	PRON
fnp-2911	121	12	contribute	contribute	VERB
fnp-2911	121	13	most	most	ADV
fnp-2911	121	14	to	to	ADP
fnp-2911	121	15	pc2	pc2	NOUN
fnp-2911	121	16	,	,	PUNCT
fnp-2911	121	17	gene	gene	NOUN
fnp-2911	121	18	ontology	ontology	NOUN
fnp-2911	121	19	analysis	analysis	NOUN
fnp-2911	121	20	was	be	AUX
fnp-2911	121	21	performed	perform	VERB
fnp-2911	121	22	using	use	VERB
fnp-2911	121	23	the	the	DET
fnp-2911	121	24	top	top	ADJ
fnp-2911	121	25	1	1	NUM
fnp-2911	121	26	%	%	NOUN
fnp-2911	121	27	of	of	ADP
fnp-2911	121	28	all	all	DET
fnp-2911	121	29	expressed	express	VERB
fnp-2911	121	30	genes	gene	NOUN
fnp-2911	121	31	(	(	PUNCT
fnp-2911	121	32	318	318	NUM
fnp-2911	121	33	genes	gene	NOUN
fnp-2911	121	34	)	)	PUNCT
fnp-2911	121	35	that	that	PRON
fnp-2911	121	36	contribute	contribute	VERB
fnp-2911	121	37	to	to	ADP
fnp-2911	121	38	pc2	pc2	NOUN
fnp-2911	121	39	.	.	PUNCT
fnp-2911	122	1	one	one	NUM
fnp-2911	122	2	pathway	pathway	NOUN
fnp-2911	122	3	that	that	PRON
fnp-2911	122	4	is	be	AUX
fnp-2911	122	5	of	of	ADP
fnp-2911	122	6	interest	interest	NOUN
fnp-2911	122	7	is	be	AUX
fnp-2911	122	8	the	the	DET
fnp-2911	122	9	cytoplasmic	cytoplasmic	ADJ
fnp-2911	122	10	vesicle	vesicle	NOUN
fnp-2911	122	11	part	part	NOUN
fnp-2911	122	12	or	or	CCONJ
fnp-2911	122	13	cytoplasmic	cytoplasmic	ADJ
fnp-2911	122	14	vesicle	vesicle	NOUN
fnp-2911	122	15	membrane	membrane	NOUN
fnp-2911	122	16	(	(	PUNCT
fnp-2911	122	17	table	table	NOUN
fnp-2911	122	18	2	2	NUM
fnp-2911	122	19	)	)	PUNCT
fnp-2911	122	20	and	and	CCONJ
fnp-2911	122	21	is	be	AUX
fnp-2911	122	22	consistent	consistent	ADJ
fnp-2911	122	23	with	with	ADP
fnp-2911	122	24	the	the	DET
fnp-2911	122	25	functional	functional	ADJ
fnp-2911	122	26	role	role	NOUN
fnp-2911	122	27	of	of	ADP
fnp-2911	122	28	c9orf72	c9orf72	PROPN
fnp-2911	122	29	as	as	ADP
fnp-2911	122	30	a	a	DET
fnp-2911	122	31	vesicle	vesicle	NOUN
fnp-2911	122	32	trafficking	traffic	VERB
fnp-2911	122	33	protein	protein	NOUN
fnp-2911	122	34	and	and	CCONJ
fnp-2911	122	35	rab	rab	NOUN
fnp-2911	122	36	gtpase	gtpase	NOUN
fnp-2911	122	37	(	(	PUNCT
fnp-2911	122	38	3	3	NUM
fnp-2911	122	39	,	,	PUNCT
fnp-2911	122	40	5	5	NUM
fnp-2911	122	41	-	-	SYM
fnp-2911	122	42	7	7	NUM
fnp-2911	122	43	)	)	PUNCT
fnp-2911	122	44	.	.	PUNCT
fnp-2911	123	1	table	table	NOUN
fnp-2911	123	2	2	2	NUM
fnp-2911	123	3	:	:	PUNCT
fnp-2911	123	4	gene	gene	NOUN
fnp-2911	123	5	ontology	ontology	NOUN
fnp-2911	123	6	(	(	PUNCT
fnp-2911	123	7	go	go	VERB
fnp-2911	123	8	)	)	PUNCT
fnp-2911	123	9	of	of	ADP
fnp-2911	123	10	genes	gene	NOUN
fnp-2911	123	11	related	relate	VERB
fnp-2911	123	12	to	to	ADP
fnp-2911	123	13	top	top	ADJ
fnp-2911	123	14	1	1	NUM
fnp-2911	123	15	%	%	NOUN
fnp-2911	123	16	of	of	ADP
fnp-2911	123	17	all	all	DET
fnp-2911	123	18	genes	gene	NOUN
fnp-2911	123	19	that	that	PRON
fnp-2911	123	20	contribute	contribute	VERB
fnp-2911	123	21	to	to	ADP
fnp-2911	123	22	variation	variation	NOUN
fnp-2911	123	23	in	in	ADP
fnp-2911	123	24	pc2	pc2	NOUN
fnp-2911	123	25	.	.	PUNCT
fnp-2911	124	1	previous	previous	ADJ
fnp-2911	124	2	studies	study	NOUN
fnp-2911	124	3	have	have	AUX
fnp-2911	124	4	found	find	VERB
fnp-2911	124	5	that	that	SCONJ
fnp-2911	124	6	the	the	DET
fnp-2911	124	7	g4c2	g4c2	PROPN
fnp-2911	124	8	rna	rna	NOUN
fnp-2911	124	9	foci	focus	NOUN
fnp-2911	124	10	may	may	AUX
fnp-2911	124	11	colocalize	colocalize	VERB
fnp-2911	124	12	with	with	ADP
fnp-2911	124	13	different	different	ADJ
fnp-2911	124	14	rna	rna	NOUN
fnp-2911	124	15	binding	bind	VERB
fnp-2911	124	16	proteins	protein	NOUN
fnp-2911	124	17	(	(	PUNCT
fnp-2911	124	18	rbps	rbps	NOUN
fnp-2911	124	19	)	)	PUNCT
fnp-2911	124	20	,	,	PUNCT
fnp-2911	124	21	suggesting	suggest	VERB
fnp-2911	124	22	that	that	SCONJ
fnp-2911	124	23	sequestration	sequestration	NOUN
fnp-2911	124	24	of	of	ADP
fnp-2911	124	25	these	these	DET
fnp-2911	124	26	rbps	rbps	NOUN
fnp-2911	124	27	can	can	AUX
fnp-2911	124	28	result	result	VERB
fnp-2911	124	29	in	in	ADP
fnp-2911	124	30	aberrant	aberrant	ADJ
fnp-2911	124	31	rna	rna	NOUN
fnp-2911	124	32	processing	processing	NOUN
fnp-2911	124	33	(	(	PUNCT
fnp-2911	124	34	10	10	NUM
fnp-2911	124	35	-	-	SYM
fnp-2911	124	36	12	12	NUM
fnp-2911	124	37	)	)	PUNCT
fnp-2911	124	38	.	.	PUNCT
fnp-2911	125	1	differential	differential	ADJ
fnp-2911	125	2	gene	gene	NOUN
fnp-2911	125	3	expression	expression	NOUN
fnp-2911	125	4	analysis	analysis	NOUN
fnp-2911	125	5	showed	show	VERB
fnp-2911	125	6	that	that	SCONJ
fnp-2911	125	7	there	there	PRON
fnp-2911	125	8	are	be	VERB
fnp-2911	125	9	323	323	NUM
fnp-2911	125	10	significantly	significantly	ADV
fnp-2911	125	11	differentially	differentially	ADV
fnp-2911	125	12	expressed	express	VERB
fnp-2911	125	13	genes	gene	NOUN
fnp-2911	125	14	with	with	ADP
fnp-2911	125	15	202	202	NUM
fnp-2911	125	16	upregulated	upregulate	VERB
fnp-2911	125	17	and	and	CCONJ
fnp-2911	125	18	121	121	NUM
fnp-2911	125	19	downregulated	downregulate	VERB
fnp-2911	125	20	genes	gene	NOUN
fnp-2911	125	21	linked	link	VERB
fnp-2911	125	22	to	to	ADP
fnp-2911	125	23	the	the	DET
fnp-2911	125	24	c9orf72	c9orf72	PROPN
fnp-2911	125	25	mutation	mutation	NOUN
fnp-2911	125	26	(	(	PUNCT
fnp-2911	125	27	fig	fig	NOUN
fnp-2911	125	28	1e	1e	NOUN
fnp-2911	125	29	,	,	PUNCT
fnp-2911	125	30	supplemental	supplemental	ADJ
fnp-2911	125	31	table	table	NOUN
fnp-2911	125	32	1	1	NUM
fnp-2911	125	33	)	)	PUNCT
fnp-2911	125	34	.	.	PUNCT
fnp-2911	126	1	similar	similar	ADJ
fnp-2911	126	2	to	to	ADP
fnp-2911	126	3	a	a	DET
fnp-2911	126	4	previous	previous	ADJ
fnp-2911	126	5	transcriptome	transcriptome	ADJ
fnp-2911	126	6	analysis	analysis	NOUN
fnp-2911	126	7	on	on	ADP
fnp-2911	126	8	c9orf72	c9orf72	ADJ
fnp-2911	126	9	expansion	expansion	NOUN
fnp-2911	126	10	carriers	carrier	NOUN
fnp-2911	126	11	on	on	ADP
fnp-2911	126	12	the	the	DET
fnp-2911	126	13	frontal	frontal	ADJ
fnp-2911	126	14	cortex	cortex	NOUN
fnp-2911	126	15	,	,	PUNCT
fnp-2911	126	16	there	there	PRON
fnp-2911	126	17	were	be	VERB
fnp-2911	126	18	more	more	ADV
fnp-2911	126	19	upregulated	upregulated	ADJ
fnp-2911	126	20	genes	gene	NOUN
fnp-2911	126	21	than	than	ADP
fnp-2911	126	22	downregulated	downregulate	VERB
fnp-2911	126	23	genes	gene	NOUN
fnp-2911	126	24	within	within	ADP
fnp-2911	126	25	the	the	DET
fnp-2911	126	26	differentially	differentially	ADV
fnp-2911	126	27	expressed	express	VERB
fnp-2911	126	28	genes	gene	NOUN
fnp-2911	126	29	(	(	PUNCT
fnp-2911	126	30	49	49	NUM
fnp-2911	126	31	)	)	PUNCT
fnp-2911	126	32	.	.	PUNCT
fnp-2911	127	1	notably	notably	ADV
fnp-2911	127	2	,	,	PUNCT
fnp-2911	127	3	the	the	DET
fnp-2911	127	4	number	number	NOUN
fnp-2911	127	5	of	of	ADP
fnp-2911	127	6	differentially	differentially	ADV
fnp-2911	127	7	expressed	express	VERB
fnp-2911	127	8	genes	gene	NOUN
fnp-2911	127	9	linked	link	VERB
fnp-2911	127	10	the	the	DET
fnp-2911	127	11	c9orf72	c9orf72	PROPN
fnp-2911	127	12	repeat	repeat	NOUN
fnp-2911	127	13	expansion	expansion	NOUN
fnp-2911	127	14	was	be	AUX
fnp-2911	127	15	relatively	relatively	ADV
fnp-2911	127	16	mild	mild	ADJ
fnp-2911	127	17	compared	compare	VERB
fnp-2911	127	18	to	to	ADP
fnp-2911	127	19	the	the	DET
fnp-2911	127	20	massive	massive	ADJ
fnp-2911	127	21	transcriptome	transcriptome	ADJ
fnp-2911	127	22	-	-	PUNCT
fnp-2911	127	23	wide	wide	ADJ
fnp-2911	127	24	alterations	alteration	NOUN
fnp-2911	127	25	we	we	PRON
fnp-2911	127	26	previously	previously	ADV
fnp-2911	127	27	described	describe	VERB
fnp-2911	127	28	associated	associate	VERB
fnp-2911	127	29	with	with	ADP
fnp-2911	127	30	tdp-43	tdp-43	PROPN
fnp-2911	127	31	pathology	pathology	NOUN
fnp-2911	127	32	in	in	ADP
fnp-2911	127	33	these	these	DET
fnp-2911	127	34	same	same	ADJ
fnp-2911	127	35	cases	case	NOUN
fnp-2911	127	36	(	(	PUNCT
fnp-2911	127	37	5,576	5,576	NUM
fnp-2911	127	38	significantly	significantly	ADV
fnp-2911	127	39	differentially	differentially	ADV
fnp-2911	127	40	expressed	express	VERB
fnp-2911	127	41	genes	gene	NOUN
fnp-2911	127	42	,	,	PUNCT
fnp-2911	127	43	described	describe	VERB
fnp-2911	127	44	in	in	ADP
fnp-2911	127	45	(	(	PUNCT
fnp-2911	127	46	52	52	NUM
fnp-2911	127	47	)	)	PUNCT
fnp-2911	127	48	)	)	PUNCT
fnp-2911	127	49	.	.	PUNCT
fnp-2911	128	1	further	further	ADJ
fnp-2911	128	2	annotation	annotation	NOUN
fnp-2911	128	3	shows	show	VERB
fnp-2911	128	4	that	that	SCONJ
fnp-2911	128	5	these	these	DET
fnp-2911	128	6	genes	gene	NOUN
fnp-2911	128	7	are	be	AUX
fnp-2911	128	8	generally	generally	ADV
fnp-2911	128	9	involved	involve	VERB
fnp-2911	128	10	in	in	ADP
fnp-2911	128	11	synaptic	synaptic	ADJ
fnp-2911	128	12	vesicle	vesicle	NOUN
fnp-2911	128	13	fusion	fusion	NOUN
fnp-2911	128	14	or	or	CCONJ
fnp-2911	128	15	vesicle	vesicle	NOUN
fnp-2911	128	16	formation	formation	NOUN
fnp-2911	128	17	(	(	PUNCT
fnp-2911	128	18	table	table	NOUN
fnp-2911	128	19	3	3	NUM
fnp-2911	128	20	)	)	PUNCT
fnp-2911	128	21	.	.	PUNCT
fnp-2911	129	1	additional	additional	ADJ
fnp-2911	129	2	genes	gene	NOUN
fnp-2911	129	3	related	relate	VERB
fnp-2911	129	4	to	to	ADP
fnp-2911	129	5	vesicle	vesicle	NOUN
fnp-2911	129	6	transport	transport	NOUN
fnp-2911	129	7	and	and	CCONJ
fnp-2911	129	8	endosomal	endosomal	ADJ
fnp-2911	129	9	trafficking	trafficking	NOUN
fnp-2911	129	10	are	be	AUX
fnp-2911	129	11	also	also	ADV
fnp-2911	129	12	dysregulated	dysregulate	VERB
fnp-2911	129	13	.	.	PUNCT
fnp-2911	130	1	interestingly	interestingly	ADV
fnp-2911	130	2	,	,	PUNCT
fnp-2911	130	3	nine	nine	NUM
fnp-2911	130	4	out	out	ADP
fnp-2911	130	5	of	of	ADP
fnp-2911	130	6	these	these	DET
fnp-2911	130	7	11	11	NUM
fnp-2911	130	8	genes	gene	NOUN
fnp-2911	130	9	are	be	AUX
fnp-2911	130	10	upregulated	upregulate	VERB
fnp-2911	130	11	.	.	PUNCT
fnp-2911	131	1	additional	additional	ADJ
fnp-2911	131	2	genes	gene	NOUN
fnp-2911	131	3	that	that	PRON
fnp-2911	131	4	were	be	AUX
fnp-2911	131	5	upregulated	upregulate	VERB
fnp-2911	131	6	were	be	AUX
fnp-2911	131	7	involved	involve	VERB
fnp-2911	131	8	in	in	ADP
fnp-2911	131	9	protein	protein	NOUN
fnp-2911	131	10	aggregation	aggregation	NOUN
fnp-2911	131	11	.	.	PUNCT
fnp-2911	132	1	dnajb2	dnajb2	NOUN
fnp-2911	132	2	is	be	AUX
fnp-2911	132	3	almost	almost	ADV
fnp-2911	132	4	exclusively	exclusively	ADV
fnp-2911	132	5	expressed	express	VERB
fnp-2911	132	6	in	in	ADP
fnp-2911	132	7	neurons	neuron	NOUN
fnp-2911	132	8	and	and	CCONJ
fnp-2911	132	9	has	have	AUX
fnp-2911	132	10	been	be	AUX
fnp-2911	132	11	shown	show	VERB
fnp-2911	132	12	to	to	PART
fnp-2911	132	13	resolve	resolve	VERB
fnp-2911	132	14	tdp-43	tdp-43	NOUN
fnp-2911	132	15	aggregates	aggregate	NOUN
fnp-2911	132	16	by	by	ADP
fnp-2911	132	17	interacting	interact	VERB
fnp-2911	132	18	with	with	ADP
fnp-2911	132	19	heat	heat	NOUN
fnp-2911	132	20	shock	shock	NOUN
fnp-2911	132	21	protein	protein	NOUN
fnp-2911	132	22	70	70	NUM
fnp-2911	132	23	(	(	PUNCT
fnp-2911	132	24	57	57	NUM
fnp-2911	132	25	)	)	PUNCT
fnp-2911	132	26	.	.	PUNCT
fnp-2911	133	1	mgrn1	mgrn1	NOUN
fnp-2911	133	2	has	have	AUX
fnp-2911	133	3	been	be	AUX
fnp-2911	133	4	shown	show	VERB
fnp-2911	133	5	to	to	PART
fnp-2911	133	6	confer	confer	VERB
fnp-2911	133	7	cytoprotective	cytoprotective	ADJ
fnp-2911	133	8	effects	effect	NOUN
fnp-2911	133	9	in	in	ADP
fnp-2911	133	10	an	an	DET
fnp-2911	133	11	als	als	NOUN
fnp-2911	133	12	mouse	mouse	NOUN
fnp-2911	133	13	model	model	NOUN
fnp-2911	133	14	and	and	CCONJ
fnp-2911	133	15	can	can	AUX
fnp-2911	133	16	suppress	suppress	VERB
fnp-2911	133	17	chaperone	chaperone	NOUN
fnp-2911	133	18	associated	associate	VERB
fnp-2911	133	19	misfolded	misfolde	VERB
fnp-2911	133	20	protein	protein	NOUN
fnp-2911	133	21	aggregation	aggregation	NOUN
fnp-2911	133	22	and	and	CCONJ
fnp-2911	133	23	toxicity	toxicity	NOUN
fnp-2911	133	24	(	(	PUNCT
fnp-2911	133	25	58	58	NUM
fnp-2911	133	26	)	)	PUNCT
fnp-2911	133	27	.	.	PUNCT
fnp-2911	134	1	given	give	VERB
fnp-2911	134	2	that	that	DET
fnp-2911	134	3	c9orf72	c9orf72	ADJ
fnp-2911	134	4	expansion	expansion	NOUN
fnp-2911	134	5	cases	case	NOUN
fnp-2911	134	6	exhibit	exhibit	VERB
fnp-2911	134	7	protein	protein	NOUN
fnp-2911	134	8	aggregates	aggregate	NOUN
fnp-2911	134	9	in	in	ADP
fnp-2911	134	10	the	the	DET
fnp-2911	134	11	form	form	NOUN
fnp-2911	134	12	of	of	ADP
fnp-2911	134	13	dipeptide	dipeptide	NOUN
fnp-2911	134	14	repeat	repeat	NOUN
fnp-2911	134	15	protein	protein	NOUN
fnp-2911	134	16	and	and	CCONJ
fnp-2911	134	17	tdp-43	tdp-43	NOUN
fnp-2911	134	18	inclusions	inclusion	NOUN
fnp-2911	134	19	,	,	PUNCT
fnp-2911	134	20	it	it	PRON
fnp-2911	134	21	is	be	AUX
fnp-2911	134	22	possible	possible	ADJ
fnp-2911	134	23	that	that	SCONJ
fnp-2911	134	24	these	these	DET
fnp-2911	134	25	genes	gene	NOUN
fnp-2911	134	26	are	be	AUX
fnp-2911	134	27	upregulated	upregulate	VERB
fnp-2911	134	28	in	in	ADP
fnp-2911	134	29	response	response	NOUN
fnp-2911	134	30	to	to	ADP
fnp-2911	134	31	these	these	DET
fnp-2911	134	32	aggregates	aggregate	NOUN
fnp-2911	134	33	.	.	PUNCT
fnp-2911	135	1	lastly	lastly	ADV
fnp-2911	135	2	,	,	PUNCT
fnp-2911	135	3	there	there	PRON
fnp-2911	135	4	were	be	VERB
fnp-2911	135	5	also	also	ADV
fnp-2911	135	6	genes	gene	NOUN
fnp-2911	135	7	that	that	PRON
fnp-2911	135	8	are	be	AUX
fnp-2911	135	9	involved	involve	VERB
fnp-2911	135	10	in	in	ADP
fnp-2911	135	11	dna	dna	PROPN
fnp-2911	135	12	repair	repair	NOUN
fnp-2911	135	13	(	(	PUNCT
fnp-2911	135	14	faap20	faap20	NOUN
fnp-2911	135	15	,	,	PUNCT
fnp-2911	135	16	fam175a	fam175a	NOUN
fnp-2911	135	17	,	,	PUNCT
fnp-2911	135	18	fancb	fancb	NOUN
fnp-2911	135	19	,	,	PUNCT
fnp-2911	135	20	hmgn1	hmgn1	PROPN
fnp-2911	135	21	)	)	PUNCT
fnp-2911	135	22	(	(	PUNCT
fnp-2911	135	23	59	59	NUM
fnp-2911	135	24	-	-	SYM
fnp-2911	135	25	62	62	NUM
fnp-2911	135	26	)	)	PUNCT
fnp-2911	135	27	and	and	CCONJ
fnp-2911	135	28	response	response	NOUN
fnp-2911	135	29	to	to	ADP
fnp-2911	135	30	dna	dna	PROPN
fnp-2911	135	31	damage	damage	NOUN
fnp-2911	135	32	(	(	PUNCT
fnp-2911	135	33	kdm4b	kdm4b	NOUN
fnp-2911	135	34	and	and	CCONJ
fnp-2911	135	35	kin	kin	PROPN
fnp-2911	135	36	)	)	PUNCT
fnp-2911	135	37	(	(	PUNCT
fnp-2911	135	38	63	63	NUM
fnp-2911	135	39	-	-	SYM
fnp-2911	135	40	65	65	NUM
fnp-2911	135	41	)	)	PUNCT
fnp-2911	135	42	.	.	PUNCT
fnp-2911	136	1	annotation	annotation	NOUN
fnp-2911	136	2	of	of	ADP
fnp-2911	136	3	these	these	DET
fnp-2911	136	4	genes	gene	NOUN
fnp-2911	136	5	reveal	reveal	VERB
fnp-2911	136	6	multiple	multiple	ADJ
fnp-2911	136	7	themes	theme	NOUN
fnp-2911	136	8	relevant	relevant	ADJ
fnp-2911	136	9	to	to	ADP
fnp-2911	136	10	c9orf72	c9orf72	PROPN
fnp-2911	136	11	including	include	VERB
fnp-2911	136	12	synaptic	synaptic	ADJ
fnp-2911	136	13	vesicle	vesicle	NOUN
fnp-2911	136	14	formation	formation	NOUN
fnp-2911	136	15	,	,	PUNCT
fnp-2911	136	16	endosomal	endosomal	ADJ
fnp-2911	136	17	trafficking	trafficking	NOUN
fnp-2911	136	18	,	,	PUNCT
fnp-2911	136	19	chaperone	chaperone	NOUN
fnp-2911	136	20	associated	associate	VERB
fnp-2911	136	21	protein	protein	NOUN
fnp-2911	136	22	aggregation	aggregation	NOUN
fnp-2911	136	23	,	,	PUNCT
fnp-2911	136	24	and	and	CCONJ
fnp-2911	136	25	dna	dna	PROPN
fnp-2911	136	26	damage	damage	NOUN
fnp-2911	136	27	(	(	PUNCT
fnp-2911	136	28	table	table	NOUN
fnp-2911	136	29	3	3	NUM
fnp-2911	136	30	)	)	PUNCT
fnp-2911	136	31	.	.	PUNCT
fnp-2911	137	1	c9orf72	c9orf72	PROPN
fnp-2911	137	2	mutation	mutation	NOUN
fnp-2911	137	3	is	be	AUX
fnp-2911	137	4	associated	associate	VERB
fnp-2911	137	5	with	with	ADP
fnp-2911	137	6	mild	mild	ADJ
fnp-2911	137	7	splicing	splicing	NOUN
fnp-2911	137	8	alterations	alteration	NOUN
fnp-2911	137	9	previous	previous	ADJ
fnp-2911	137	10	studies	study	NOUN
fnp-2911	137	11	have	have	AUX
fnp-2911	137	12	shown	show	VERB
fnp-2911	137	13	that	that	SCONJ
fnp-2911	137	14	there	there	PRON
fnp-2911	137	15	are	be	VERB
fnp-2911	137	16	abundant	abundant	ADJ
fnp-2911	137	17	alternative	alternative	ADJ
fnp-2911	137	18	splicing	splicing	NOUN
fnp-2911	137	19	changes	change	NOUN
fnp-2911	137	20	that	that	PRON
fnp-2911	137	21	are	be	AUX
fnp-2911	137	22	linked	link	VERB
fnp-2911	137	23	to	to	ADP
fnp-2911	137	24	the	the	DET
fnp-2911	137	25	c9orf72	c9orf72	PROPN
fnp-2911	137	26	mutation	mutation	NOUN
fnp-2911	137	27	(	(	PUNCT
fnp-2911	137	28	49	49	NUM
fnp-2911	137	29	)	)	PUNCT
fnp-2911	137	30	.	.	PUNCT
fnp-2911	138	1	the	the	DET
fnp-2911	138	2	finding	finding	NOUN
fnp-2911	138	3	of	of	ADP
fnp-2911	138	4	rna	rna	NOUN
fnp-2911	138	5	binding	bind	VERB
fnp-2911	138	6	proteins	protein	NOUN
fnp-2911	138	7	that	that	PRON
fnp-2911	138	8	colocalize	colocalize	VERB
fnp-2911	138	9	with	with	ADP
fnp-2911	138	10	rna	rna	NOUN
fnp-2911	138	11	foci	focus	NOUN
fnp-2911	138	12	also	also	ADV
fnp-2911	138	13	support	support	VERB
fnp-2911	138	14	the	the	DET
fnp-2911	138	15	idea	idea	NOUN
fnp-2911	138	16	that	that	PRON
fnp-2911	138	17	rna	rna	VERB
fnp-2911	138	18	binding	bind	VERB
fnp-2911	138	19	protein	protein	NOUN
fnp-2911	138	20	sequestration	sequestration	NOUN
fnp-2911	138	21	and	and	CCONJ
fnp-2911	138	22	subsequent	subsequent	ADJ
fnp-2911	138	23	splicing	splicing	NOUN
fnp-2911	138	24	alterations	alteration	NOUN
fnp-2911	138	25	may	may	AUX
fnp-2911	138	26	contribute	contribute	VERB
fnp-2911	138	27	to	to	ADP
fnp-2911	138	28	mutant	mutant	ADJ
fnp-2911	138	29	c9orf72	c9orf72	ADJ
fnp-2911	138	30	toxicity	toxicity	NOUN
fnp-2911	138	31	.	.	PUNCT
fnp-2911	139	1	to	to	PART
fnp-2911	139	2	evaluate	evaluate	VERB
fnp-2911	139	3	splicing	splicing	NOUN
fnp-2911	139	4	changes	change	NOUN
fnp-2911	139	5	associated	associate	VERB
fnp-2911	139	6	with	with	ADP
fnp-2911	139	7	the	the	DET
fnp-2911	139	8	c9orf72	c9orf72	PROPN
fnp-2911	139	9	mutation	mutation	NOUN
fnp-2911	139	10	,	,	PUNCT
fnp-2911	139	11	rmats	rmat	NOUN
fnp-2911	139	12	was	be	AUX
fnp-2911	139	13	used	use	VERB
fnp-2911	139	14	to	to	PART
fnp-2911	139	15	align	align	VERB
fnp-2911	139	16	junction	junction	NOUN
fnp-2911	139	17	reads	read	NOUN
fnp-2911	139	18	to	to	ADP
fnp-2911	139	19	annotated	annotate	VERB
fnp-2911	139	20	junctions	junction	NOUN
fnp-2911	139	21	from	from	ADP
fnp-2911	139	22	grch38	grch38	NOUN
fnp-2911	139	23	assembly	assembly	NOUN
fnp-2911	139	24	.	.	PUNCT
fnp-2911	140	1	within	within	ADP
fnp-2911	140	2	our	our	PRON
fnp-2911	140	3	dataset	dataset	NOUN
fnp-2911	140	4	,	,	PUNCT
fnp-2911	140	5	there	there	PRON
fnp-2911	140	6	were	be	VERB
fnp-2911	140	7	a	a	DET
fnp-2911	140	8	total	total	NOUN
fnp-2911	140	9	of	of	ADP
fnp-2911	140	10	112	112	NUM
fnp-2911	140	11	events	event	NOUN
fnp-2911	140	12	that	that	PRON
fnp-2911	140	13	were	be	AUX
fnp-2911	140	14	significantly	significantly	ADV
fnp-2911	140	15	alternatively	alternatively	ADV
fnp-2911	140	16	spliced	splice	VERB
fnp-2911	140	17	which	which	PRON
fnp-2911	140	18	included	include	VERB
fnp-2911	140	19	84	84	NUM
fnp-2911	140	20	skipped	skip	VERB
fnp-2911	140	21	exons	exon	NOUN
fnp-2911	140	22	(	(	PUNCT
fnp-2911	140	23	se	se	X
fnp-2911	140	24	)	)	PUNCT
fnp-2911	140	25	,	,	PUNCT
fnp-2911	140	26	9	9	NUM
fnp-2911	140	27	mutually	mutually	ADV
fnp-2911	140	28	exclusive	exclusive	ADJ
fnp-2911	140	29	exons	exon	NOUN
fnp-2911	140	30	(	(	PUNCT
fnp-2911	140	31	mxe	mxe	NOUN
fnp-2911	140	32	)	)	PUNCT
fnp-2911	140	33	,	,	PUNCT
fnp-2911	140	34	9	9	NUM
fnp-2911	140	35	retained	retain	VERB
fnp-2911	140	36	introns	intron	NOUN
fnp-2911	140	37	(	(	PUNCT
fnp-2911	140	38	ri	ri	NOUN
fnp-2911	140	39	)	)	PUNCT
fnp-2911	140	40	,	,	PUNCT
fnp-2911	140	41	8	8	NUM
fnp-2911	140	42	alternative	alternative	NOUN
fnp-2911	140	43	3	3	NUM
fnp-2911	140	44	’	'	PUNCT
fnp-2911	140	45	splice	splice	NOUN
fnp-2911	140	46	sites	site	NOUN
fnp-2911	140	47	(	(	PUNCT
fnp-2911	140	48	a3ss	a3ss	NOUN
fnp-2911	140	49	)	)	PUNCT
fnp-2911	140	50	,	,	PUNCT
fnp-2911	140	51	and	and	CCONJ
fnp-2911	140	52	2	2	NUM
fnp-2911	140	53	alternative	alternative	ADJ
fnp-2911	140	54	5	5	NUM
fnp-2911	140	55	’	'	PUNCT
fnp-2911	140	56	splice	splice	NOUN
fnp-2911	140	57	site	site	NOUN
fnp-2911	140	58	(	(	PUNCT
fnp-2911	140	59	a5ss	a5ss	NOUN
fnp-2911	140	60	)	)	PUNCT
fnp-2911	140	61	events	event	NOUN
fnp-2911	140	62	(	(	PUNCT
fnp-2911	140	63	fig	fig	NOUN
fnp-2911	140	64	1f	1f	NUM
fnp-2911	140	65	,	,	PUNCT
fnp-2911	140	66	supplemental	supplemental	ADJ
fnp-2911	140	67	table	table	NOUN
fnp-2911	140	68	2	2	NUM
fnp-2911	140	69	)	)	PUNCT
fnp-2911	140	70	.	.	PUNCT
fnp-2911	141	1	these	these	DET
fnp-2911	141	2	events	event	NOUN
fnp-2911	141	3	affected	affect	VERB
fnp-2911	141	4	111	111	NUM
fnp-2911	141	5	genes	gene	NOUN
fnp-2911	141	6	,	,	PUNCT
fnp-2911	141	7	of	of	ADP
fnp-2911	141	8	which	which	PRON
fnp-2911	141	9	only	only	ADV
fnp-2911	141	10	3	3	NUM
fnp-2911	141	11	were	be	AUX
fnp-2911	141	12	also	also	ADV
fnp-2911	141	13	significantly	significantly	ADV
fnp-2911	141	14	differentially	differentially	ADV
fnp-2911	141	15	expressed	express	VERB
fnp-2911	141	16	.	.	PUNCT
fnp-2911	142	1	gene	gene	NOUN
fnp-2911	142	2	ontology	ontology	NOUN
fnp-2911	142	3	analysis	analysis	NOUN
fnp-2911	142	4	of	of	ADP
fnp-2911	142	5	111	111	NUM
fnp-2911	142	6	genes	gene	NOUN
fnp-2911	142	7	did	do	AUX
fnp-2911	142	8	not	not	PART
fnp-2911	142	9	result	result	VERB
fnp-2911	142	10	in	in	ADP
fnp-2911	142	11	any	any	DET
fnp-2911	142	12	significant	significant	ADJ
fnp-2911	142	13	enriched	enriched	ADJ
fnp-2911	142	14	pathways	pathway	NOUN
fnp-2911	142	15	.	.	PUNCT
fnp-2911	143	1	therefore	therefore	ADV
fnp-2911	143	2	,	,	PUNCT
fnp-2911	143	3	we	we	PRON
fnp-2911	143	4	observed	observe	VERB
fnp-2911	143	5	relatively	relatively	ADV
fnp-2911	143	6	mild	mild	ADJ
fnp-2911	143	7	splicing	splicing	NOUN
fnp-2911	143	8	changes	change	NOUN
fnp-2911	143	9	associated	associate	VERB
fnp-2911	143	10	with	with	ADP
fnp-2911	143	11	the	the	DET
fnp-2911	143	12	c9orf72	c9orf72	PROPN
fnp-2911	143	13	mutation	mutation	NOUN
fnp-2911	143	14	.	.	PUNCT
fnp-2911	144	1	this	this	PRON
fnp-2911	144	2	may	may	AUX
fnp-2911	144	3	be	be	AUX
fnp-2911	144	4	due	due	ADJ
fnp-2911	144	5	in	in	ADP
fnp-2911	144	6	part	part	NOUN
fnp-2911	144	7	attributable	attributable	ADJ
fnp-2911	144	8	to	to	ADP
fnp-2911	144	9	technical	technical	ADJ
fnp-2911	144	10	differences	difference	NOUN
fnp-2911	144	11	where	where	SCONJ
fnp-2911	144	12	the	the	DET
fnp-2911	144	13	use	use	NOUN
fnp-2911	144	14	of	of	ADP
fnp-2911	144	15	nuclear	nuclear	ADJ
fnp-2911	144	16	rna	rna	NOUN
fnp-2911	144	17	in	in	ADP
fnp-2911	144	18	our	our	PRON
fnp-2911	144	19	study	study	NOUN
fnp-2911	144	20	likely	likely	ADV
fnp-2911	144	21	reduces	reduce	VERB
fnp-2911	144	22	sensitivity	sensitivity	NOUN
fnp-2911	144	23	in	in	ADP
fnp-2911	144	24	terms	term	NOUN
fnp-2911	144	25	of	of	ADP
fnp-2911	144	26	identifying	identify	VERB
fnp-2911	144	27	splicing	splicing	NOUN
fnp-2911	144	28	alterations	alteration	NOUN
fnp-2911	144	29	.	.	PUNCT
fnp-2911	145	1	table	table	NOUN
fnp-2911	145	2	3	3	NUM
fnp-2911	145	3	:	:	PUNCT
fnp-2911	145	4	annotation	annotation	NOUN
fnp-2911	145	5	of	of	ADP
fnp-2911	145	6	significantly	significantly	ADV
fnp-2911	145	7	differentially	differentially	ADV
fnp-2911	145	8	expressed	express	VERB
fnp-2911	145	9	genes	gene	NOUN
fnp-2911	145	10	with	with	ADP
fnp-2911	145	11	general	general	ADJ
fnp-2911	145	12	terms	term	NOUN
fnp-2911	145	13	relevant	relevant	ADJ
fnp-2911	145	14	to	to	ADP
fnp-2911	145	15	c9orf72	c9orf72	PROPN
fnp-2911	145	16	mutation	mutation	NOUN
fnp-2911	145	17	.	.	PUNCT
fnp-2911	146	1	fdr	fdr	PROPN
fnp-2911	146	2	=	=	SYM
fnp-2911	146	3	false	false	ADJ
fnp-2911	146	4	discovery	discovery	NOUN
fnp-2911	146	5	rate	rate	NOUN
fnp-2911	146	6	.	.	PUNCT
fnp-2911	147	1	fig	fig	NOUN
fnp-2911	147	2	2	2	NUM
fnp-2911	147	3	:	:	PUNCT
fnp-2911	148	1	the	the	DET
fnp-2911	148	2	c9orf72	c9orf72	PROPN
fnp-2911	148	3	mutation	mutation	NOUN
fnp-2911	148	4	is	be	AUX
fnp-2911	148	5	associated	associate	VERB
fnp-2911	148	6	with	with	ADP
fnp-2911	148	7	differential	differential	ADJ
fnp-2911	148	8	usage	usage	NOUN
fnp-2911	148	9	of	of	ADP
fnp-2911	148	10	genic	genic	ADJ
fnp-2911	148	11	elements	element	NOUN
fnp-2911	148	12	with	with	ADP
fnp-2911	148	13	rna	rna	NOUN
fnp-2911	148	14	binding	bind	VERB
fnp-2911	148	15	protein	protein	NOUN
fnp-2911	148	16	sites	site	NOUN
fnp-2911	148	17	.	.	PUNCT
fnp-2911	149	1	(	(	PUNCT
fnp-2911	149	2	a	a	X
fnp-2911	149	3	)	)	PUNCT
fnp-2911	149	4	ma	ma	PROPN
fnp-2911	149	5	plot	plot	NOUN
fnp-2911	149	6	of	of	ADP
fnp-2911	149	7	dexseq	dexseq	NOUN
fnp-2911	149	8	differentially	differentially	ADV
fnp-2911	149	9	used	use	VERB
fnp-2911	149	10	genic	genic	ADJ
fnp-2911	149	11	elements	element	NOUN
fnp-2911	149	12	with	with	ADP
fnp-2911	149	13	red	red	ADJ
fnp-2911	149	14	being	be	AUX
fnp-2911	149	15	significantly	significantly	ADV
fnp-2911	149	16	differentially	differentially	ADV
fnp-2911	149	17	used	use	VERB
fnp-2911	149	18	elements	element	NOUN
fnp-2911	149	19	.	.	PUNCT
fnp-2911	150	1	(	(	PUNCT
fnp-2911	150	2	b	b	X
fnp-2911	150	3	)	)	PUNCT
fnp-2911	150	4	genic	genic	ADJ
fnp-2911	150	5	elements	element	NOUN
fnp-2911	150	6	(	(	PUNCT
fnp-2911	150	7	5	5	NUM
fnp-2911	150	8	’	'	PUNCT
fnp-2911	150	9	utr	utr	PROPN
fnp-2911	150	10	,	,	PUNCT
fnp-2911	150	11	exon	exon	PROPN
fnp-2911	150	12	,	,	PUNCT
fnp-2911	150	13	intron	intron	NOUN
fnp-2911	150	14	,	,	PUNCT
fnp-2911	150	15	3	3	NUM
fnp-2911	150	16	’	'	PUNCT
fnp-2911	150	17	utr	utr	NOUN
fnp-2911	150	18	)	)	PUNCT
fnp-2911	150	19	distribution	distribution	NOUN
fnp-2911	150	20	associated	associate	VERB
fnp-2911	150	21	with	with	ADP
fnp-2911	150	22	c9orf72	c9orf72	ADJ
fnp-2911	150	23	mutation	mutation	NOUN
fnp-2911	150	24	and	and	CCONJ
fnp-2911	150	25	all	all	DET
fnp-2911	150	26	expressed	express	VERB
fnp-2911	150	27	bins	bin	NOUN
fnp-2911	150	28	.	.	PUNCT
fnp-2911	151	1	(	(	PUNCT
fnp-2911	151	2	c	c	X
fnp-2911	151	3	)	)	PUNCT
fnp-2911	151	4	differentially	differentially	ADV
fnp-2911	151	5	used	use	VERB
fnp-2911	151	6	elements	element	NOUN
fnp-2911	151	7	that	that	PRON
fnp-2911	151	8	are	be	AUX
fnp-2911	151	9	bound	bind	VERB
fnp-2911	151	10	by	by	ADP
fnp-2911	151	11	tdp-43	tdp-43	NOUN
fnp-2911	151	12	and	and	CCONJ
fnp-2911	151	13	hnrnp	hnrnp	PROPN
fnp-2911	151	14	(	(	PUNCT
fnp-2911	151	15	χ2=5.617	χ2=5.617	NUM
fnp-2911	151	16	;	;	PUNCT
fnp-2911	151	17	p=0.0178	p=0.0178	PROPN
fnp-2911	151	18	)	)	PUNCT
fnp-2911	151	19	.	.	PUNCT
fnp-2911	152	1	c9orf72	c9orf72	PROPN
fnp-2911	152	2	mutation	mutation	NOUN
fnp-2911	152	3	is	be	AUX
fnp-2911	152	4	associated	associate	VERB
fnp-2911	152	5	with	with	ADP
fnp-2911	152	6	differentially	differentially	ADV
fnp-2911	152	7	used	use	VERB
fnp-2911	152	8	3	3	NUM
fnp-2911	152	9	’	'	PUNCT
fnp-2911	152	10	utrs	utrs	PROPN
fnp-2911	152	11	altered	alter	VERB
fnp-2911	152	12	rna	rna	NOUN
fnp-2911	152	13	binding	bind	VERB
fnp-2911	152	14	protein	protein	NOUN
fnp-2911	152	15	function	function	NOUN
fnp-2911	152	16	has	have	AUX
fnp-2911	152	17	been	be	AUX
fnp-2911	152	18	proposed	propose	VERB
fnp-2911	152	19	to	to	PART
fnp-2911	152	20	contribute	contribute	VERB
fnp-2911	152	21	to	to	ADP
fnp-2911	152	22	c9orf72	c9orf72	ADJ
fnp-2911	152	23	toxicity	toxicity	NOUN
fnp-2911	152	24	.	.	PUNCT
fnp-2911	153	1	rna	rna	NOUN
fnp-2911	153	2	binding	bind	VERB
fnp-2911	153	3	proteins	protein	NOUN
fnp-2911	153	4	can	can	AUX
fnp-2911	153	5	bind	bind	VERB
fnp-2911	153	6	to	to	ADP
fnp-2911	153	7	different	different	ADJ
fnp-2911	153	8	genic	genic	ADJ
fnp-2911	153	9	elements	element	NOUN
fnp-2911	153	10	including	include	VERB
fnp-2911	153	11	exons	exon	NOUN
fnp-2911	153	12	,	,	PUNCT
fnp-2911	153	13	introns	intron	NOUN
fnp-2911	153	14	and	and	CCONJ
fnp-2911	153	15	untranslated	untranslated	ADJ
fnp-2911	153	16	regions	region	NOUN
fnp-2911	153	17	(	(	PUNCT
fnp-2911	153	18	utr	utr	NOUN
fnp-2911	153	19	)	)	PUNCT
fnp-2911	153	20	.	.	PUNCT
fnp-2911	154	1	if	if	SCONJ
fnp-2911	154	2	rbp	rbp	PROPN
fnp-2911	154	3	activity	activity	NOUN
fnp-2911	154	4	is	be	AUX
fnp-2911	154	5	altered	alter	VERB
fnp-2911	154	6	via	via	ADP
fnp-2911	154	7	titration	titration	NOUN
fnp-2911	154	8	of	of	ADP
fnp-2911	154	9	these	these	DET
fnp-2911	154	10	proteins	protein	NOUN
fnp-2911	154	11	,	,	PUNCT
fnp-2911	154	12	it	it	PRON
fnp-2911	154	13	is	be	AUX
fnp-2911	154	14	possible	possible	ADJ
fnp-2911	154	15	the	the	DET
fnp-2911	154	16	regions	region	NOUN
fnp-2911	154	17	that	that	PRON
fnp-2911	154	18	may	may	AUX
fnp-2911	154	19	be	be	AUX
fnp-2911	154	20	bound	bind	VERB
fnp-2911	154	21	by	by	ADP
fnp-2911	154	22	rbps	rbps	NOUN
fnp-2911	154	23	are	be	AUX
fnp-2911	154	24	also	also	ADV
fnp-2911	154	25	differentially	differentially	ADV
fnp-2911	154	26	expressed	express	VERB
fnp-2911	154	27	.	.	PUNCT
fnp-2911	155	1	thus	thus	ADV
fnp-2911	155	2	,	,	PUNCT
fnp-2911	155	3	dexseq	dexseq	PROPN
fnp-2911	155	4	was	be	AUX
fnp-2911	155	5	used	use	VERB
fnp-2911	155	6	to	to	PART
fnp-2911	155	7	determine	determine	VERB
fnp-2911	155	8	whether	whether	SCONJ
fnp-2911	155	9	the	the	DET
fnp-2911	155	10	presence	presence	NOUN
fnp-2911	155	11	of	of	ADP
fnp-2911	155	12	the	the	DET
fnp-2911	155	13	repeat	repeat	NOUN
fnp-2911	155	14	expansion	expansion	NOUN
fnp-2911	155	15	resulted	result	VERB
fnp-2911	155	16	in	in	ADP
fnp-2911	155	17	differential	differential	ADJ
fnp-2911	155	18	usage	usage	NOUN
fnp-2911	155	19	of	of	ADP
fnp-2911	155	20	genic	genic	ADJ
fnp-2911	155	21	elements	element	NOUN
fnp-2911	155	22	.	.	PUNCT
fnp-2911	156	1	there	there	PRON
fnp-2911	156	2	were	be	VERB
fnp-2911	156	3	a	a	DET
fnp-2911	156	4	total	total	NOUN
fnp-2911	156	5	of	of	ADP
fnp-2911	156	6	865	865	NUM
fnp-2911	156	7	significantly	significantly	ADV
fnp-2911	156	8	differentially	differentially	ADV
fnp-2911	156	9	used	use	VERB
fnp-2911	156	10	elements	element	NOUN
fnp-2911	156	11	linked	link	VERB
fnp-2911	156	12	to	to	ADP
fnp-2911	156	13	the	the	DET
fnp-2911	156	14	repeat	repeat	NOUN
fnp-2911	156	15	expansion	expansion	NOUN
fnp-2911	156	16	affecting	affect	VERB
fnp-2911	156	17	791	791	NUM
fnp-2911	156	18	genes	gene	NOUN
fnp-2911	156	19	.	.	PUNCT
fnp-2911	157	1	specifically	specifically	ADV
fnp-2911	157	2	,	,	PUNCT
fnp-2911	157	3	there	there	PRON
fnp-2911	157	4	were	be	VERB
fnp-2911	157	5	610	610	NUM
fnp-2911	157	6	significantly	significantly	ADV
fnp-2911	157	7	downregulated	downregulate	VERB
fnp-2911	157	8	elements	element	NOUN
fnp-2911	157	9	and	and	CCONJ
fnp-2911	157	10	255	255	NUM
fnp-2911	157	11	significantly	significantly	ADV
fnp-2911	157	12	upregulated	upregulated	ADJ
fnp-2911	157	13	elements	element	NOUN
fnp-2911	157	14	(	(	PUNCT
fnp-2911	157	15	fig	fig	NOUN
fnp-2911	157	16	2a	2a	NUM
fnp-2911	157	17	)	)	PUNCT
fnp-2911	157	18	.	.	PUNCT
fnp-2911	158	1	when	when	SCONJ
fnp-2911	158	2	the	the	DET
fnp-2911	158	3	elements	element	NOUN
fnp-2911	158	4	were	be	AUX
fnp-2911	158	5	annotated	annotate	VERB
fnp-2911	158	6	as	as	ADP
fnp-2911	158	7	either	either	DET
fnp-2911	158	8	5	5	NUM
fnp-2911	158	9	’	'	PUNCT
fnp-2911	158	10	utr	utr	PROPN
fnp-2911	158	11	,	,	PUNCT
fnp-2911	158	12	exon	exon	PROPN
fnp-2911	158	13	,	,	PUNCT
fnp-2911	158	14	intron	intron	NOUN
fnp-2911	158	15	or	or	CCONJ
fnp-2911	158	16	3	3	NUM
fnp-2911	158	17	’	'	PUNCT
fnp-2911	158	18	utr	utr	PROPN
fnp-2911	158	19	,	,	PUNCT
fnp-2911	158	20	there	there	PRON
fnp-2911	158	21	was	be	VERB
fnp-2911	158	22	a	a	DET
fnp-2911	158	23	significant	significant	ADJ
fnp-2911	158	24	enrichment	enrichment	NOUN
fnp-2911	158	25	of	of	ADP
fnp-2911	158	26	differentially	differentially	ADV
fnp-2911	158	27	used	use	VERB
fnp-2911	158	28	3	3	NUM
fnp-2911	158	29	’	'	PUNCT
fnp-2911	158	30	utrs	utrs	ADJ
fnp-2911	158	31	due	due	ADP
fnp-2911	158	32	to	to	ADP
fnp-2911	158	33	the	the	DET
fnp-2911	158	34	c9orf72	c9orf72	PROPN
fnp-2911	158	35	mutation	mutation	NOUN
fnp-2911	158	36	(	(	PUNCT
fnp-2911	158	37	13.35	13.35	NUM
fnp-2911	158	38	%	%	NOUN
fnp-2911	158	39	vs	vs	ADP
fnp-2911	158	40	9.78	9.78	NUM
fnp-2911	158	41	%	%	NOUN
fnp-2911	158	42	,	,	PUNCT
fnp-2911	158	43	χ2=12.50	χ2=12.50	PROPN
fnp-2911	158	44	,	,	PUNCT
fnp-2911	158	45	p=0.0004	p=0.0004	PROPN
fnp-2911	158	46	)	)	PUNCT
fnp-2911	158	47	(	(	PUNCT
fnp-2911	158	48	fig	fig	NOUN
fnp-2911	158	49	2b	2b	NOUN
fnp-2911	158	50	)	)	PUNCT
fnp-2911	158	51	.	.	PUNCT
fnp-2911	159	1	given	give	VERB
fnp-2911	159	2	the	the	DET
fnp-2911	159	3	role	role	NOUN
fnp-2911	159	4	of	of	ADP
fnp-2911	159	5	rbps	rbps	NOUN
fnp-2911	159	6	in	in	ADP
fnp-2911	159	7	binding	bind	VERB
fnp-2911	159	8	to	to	ADP
fnp-2911	159	9	3	3	NUM
fnp-2911	159	10	’	'	PUNCT
fnp-2911	159	11	utrs	utrs	PROPN
fnp-2911	159	12	,	,	PUNCT
fnp-2911	159	13	we	we	PRON
fnp-2911	159	14	hypothesized	hypothesize	VERB
fnp-2911	159	15	that	that	SCONJ
fnp-2911	159	16	the	the	DET
fnp-2911	159	17	significantly	significantly	ADV
fnp-2911	159	18	differentially	differentially	ADV
fnp-2911	159	19	used	use	VERB
fnp-2911	159	20	elements	element	NOUN
fnp-2911	159	21	were	be	AUX
fnp-2911	159	22	enriched	enrich	VERB
fnp-2911	159	23	for	for	ADP
fnp-2911	159	24	rbp	rbp	PROPN
fnp-2911	159	25	binding	bind	VERB
fnp-2911	159	26	sites	site	NOUN
fnp-2911	159	27	.	.	PUNCT
fnp-2911	160	1	thus	thus	ADV
fnp-2911	160	2	,	,	PUNCT
fnp-2911	160	3	hnrnp	hnrnp	ADJ
fnp-2911	160	4	binding	bind	VERB
fnp-2911	160	5	sites	site	NOUN
fnp-2911	160	6	,	,	PUNCT
fnp-2911	160	7	including	include	VERB
fnp-2911	160	8	that	that	PRON
fnp-2911	160	9	of	of	ADP
fnp-2911	160	10	tdp-43	tdp-43	PROPN
fnp-2911	160	11	and	and	CCONJ
fnp-2911	160	12	other	other	ADJ
fnp-2911	160	13	hnrnps	hnrnps	ADJ
fnp-2911	160	14	were	be	AUX
fnp-2911	160	15	identified	identify	VERB
fnp-2911	160	16	using	use	VERB
fnp-2911	160	17	pipe	pipe	NOUN
fnp-2911	160	18	-	-	PUNCT
fnp-2911	160	19	clip	clip	NOUN
fnp-2911	160	20	algorithms	algorithm	NOUN
fnp-2911	160	21	applied	apply	VERB
fnp-2911	160	22	to	to	ADP
fnp-2911	160	23	published	publish	VERB
fnp-2911	160	24	data	data	NOUN
fnp-2911	160	25	sets	set	NOUN
fnp-2911	160	26	(	(	PUNCT
fnp-2911	160	27	54	54	NUM
fnp-2911	160	28	,	,	PUNCT
fnp-2911	160	29	55	55	NUM
fnp-2911	160	30	,	,	PUNCT
fnp-2911	160	31	66	66	NUM
fnp-2911	160	32	)	)	PUNCT
fnp-2911	160	33	.	.	PUNCT
fnp-2911	161	1	indeed	indeed	ADV
fnp-2911	161	2	,	,	PUNCT
fnp-2911	161	3	there	there	PRON
fnp-2911	161	4	was	be	VERB
fnp-2911	161	5	an	an	DET
fnp-2911	161	6	enrichment	enrichment	NOUN
fnp-2911	161	7	of	of	ADP
fnp-2911	161	8	differentially	differentially	ADV
fnp-2911	161	9	used	use	VERB
fnp-2911	161	10	genic	genic	ADJ
fnp-2911	161	11	elements	element	NOUN
fnp-2911	161	12	that	that	PRON
fnp-2911	161	13	contain	contain	VERB
fnp-2911	161	14	tdp-43	tdp-43	NOUN
fnp-2911	161	15	and	and	CCONJ
fnp-2911	161	16	hnrnp	hnrnp	NOUN
fnp-2911	161	17	binding	bind	VERB
fnp-2911	161	18	sites	site	NOUN
fnp-2911	161	19	(	(	PUNCT
fnp-2911	161	20	χ2=5.617	χ2=5.617	X
fnp-2911	161	21	,	,	PUNCT
fnp-2911	161	22	p=0.0178	p=0.0178	PROPN
fnp-2911	161	23	,	,	PUNCT
fnp-2911	161	24	fig	fig	NOUN
fnp-2911	161	25	2c	2c	NUM
fnp-2911	161	26	)	)	PUNCT
fnp-2911	161	27	.	.	PUNCT
fnp-2911	162	1	thus	thus	ADV
fnp-2911	162	2	,	,	PUNCT
fnp-2911	162	3	the	the	DET
fnp-2911	162	4	c9orf72	c9orf72	PROPN
fnp-2911	162	5	expansion	expansion	NOUN
fnp-2911	162	6	is	be	AUX
fnp-2911	162	7	associated	associate	VERB
fnp-2911	162	8	with	with	ADP
fnp-2911	162	9	some	some	DET
fnp-2911	162	10	differentially	differentially	ADV
fnp-2911	162	11	used	use	VERB
fnp-2911	162	12	genic	genic	ADJ
fnp-2911	162	13	elements	element	NOUN
fnp-2911	162	14	with	with	ADP
fnp-2911	162	15	rbp	rbp	PROPN
fnp-2911	162	16	binding	binding	ADJ
fnp-2911	162	17	sites	site	NOUN
fnp-2911	162	18	.	.	PUNCT
fnp-2911	163	1	transcriptomic	transcriptomic	ADJ
fnp-2911	163	2	signature	signature	NOUN
fnp-2911	163	3	due	due	ADP
fnp-2911	163	4	to	to	ADP
fnp-2911	163	5	depletion	depletion	NOUN
fnp-2911	163	6	of	of	ADP
fnp-2911	163	7	tdp-43	tdp-43	NUM
fnp-2911	163	8	pathologic	pathologic	ADJ
fnp-2911	163	9	nuclei	nucleus	NOUN
fnp-2911	163	10	given	give	VERB
fnp-2911	163	11	that	that	SCONJ
fnp-2911	163	12	neurons	neuron	NOUN
fnp-2911	163	13	with	with	ADP
fnp-2911	163	14	tdp-43	tdp-43	NOUN
fnp-2911	163	15	inclusions	inclusion	NOUN
fnp-2911	163	16	have	have	AUX
fnp-2911	163	17	died	die	VERB
fnp-2911	163	18	during	during	ADP
fnp-2911	163	19	the	the	DET
fnp-2911	163	20	course	course	NOUN
fnp-2911	163	21	of	of	ADP
fnp-2911	163	22	disease	disease	NOUN
fnp-2911	163	23	and	and	CCONJ
fnp-2911	163	24	our	our	PRON
fnp-2911	163	25	experimental	experimental	ADJ
fnp-2911	163	26	design	design	NOUN
fnp-2911	163	27	includes	include	VERB
fnp-2911	163	28	removal	removal	NOUN
fnp-2911	163	29	of	of	ADP
fnp-2911	163	30	neurons	neuron	NOUN
fnp-2911	163	31	with	with	ADP
fnp-2911	163	32	tdp-43	tdp-43	PROPN
fnp-2911	163	33	pathology	pathology	NOUN
fnp-2911	163	34	via	via	ADP
fnp-2911	163	35	fac	fac	PROPN
fnp-2911	163	36	sorting	sort	VERB
fnp-2911	163	37	before	before	ADP
fnp-2911	163	38	rna	rna	NOUN
fnp-2911	163	39	sequencing	sequencing	NOUN
fnp-2911	163	40	,	,	PUNCT
fnp-2911	163	41	we	we	PRON
fnp-2911	163	42	next	next	ADV
fnp-2911	163	43	considered	consider	VERB
fnp-2911	163	44	the	the	DET
fnp-2911	163	45	possibility	possibility	NOUN
fnp-2911	163	46	that	that	SCONJ
fnp-2911	163	47	the	the	DET
fnp-2911	163	48	transcriptomic	transcriptomic	ADJ
fnp-2911	163	49	alterations	alteration	NOUN
fnp-2911	163	50	associated	associate	VERB
fnp-2911	163	51	with	with	ADP
fnp-2911	163	52	the	the	DET
fnp-2911	163	53	c9orf72	c9orf72	PROPN
fnp-2911	163	54	mutation	mutation	NOUN
fnp-2911	163	55	in	in	ADP
fnp-2911	163	56	this	this	DET
fnp-2911	163	57	dataset	dataset	NOUN
fnp-2911	163	58	would	would	AUX
fnp-2911	163	59	in	in	ADP
fnp-2911	163	60	part	part	NOUN
fnp-2911	163	61	reflect	reflect	VERB
fnp-2911	163	62	the	the	DET
fnp-2911	163	63	depletion	depletion	NOUN
fnp-2911	163	64	of	of	ADP
fnp-2911	163	65	neurons	neuron	NOUN
fnp-2911	163	66	vulnerable	vulnerable	ADJ
fnp-2911	163	67	to	to	ADP
fnp-2911	163	68	tdp-43	tdp-43	PROPN
fnp-2911	163	69	proteinopathy	proteinopathy	ADJ
fnp-2911	163	70	.	.	PUNCT
fnp-2911	164	1	indeed	indeed	ADV
fnp-2911	164	2	,	,	PUNCT
fnp-2911	164	3	within	within	ADP
fnp-2911	164	4	the	the	DET
fnp-2911	164	5	neocortex	neocortex	NOUN
fnp-2911	164	6	,	,	PUNCT
fnp-2911	164	7	tdp-43	tdp-43	NOUN
fnp-2911	164	8	proteinopathy	proteinopathy	ADJ
fnp-2911	164	9	often	often	ADV
fnp-2911	164	10	preferentially	preferentially	ADV
fnp-2911	164	11	affect	affect	VERB
fnp-2911	164	12	neurons	neuron	NOUN
fnp-2911	164	13	in	in	ADP
fnp-2911	164	14	superficial	superficial	ADJ
fnp-2911	164	15	cortical	cortical	ADJ
fnp-2911	164	16	laminae	laminae	NOUN
fnp-2911	164	17	(	(	PUNCT
fnp-2911	164	18	52	52	NUM
fnp-2911	164	19	,	,	PUNCT
fnp-2911	164	20	67	67	NUM
fnp-2911	164	21	)	)	PUNCT
fnp-2911	164	22	.	.	PUNCT
fnp-2911	165	1	as	as	SCONJ
fnp-2911	165	2	shown	show	VERB
fnp-2911	165	3	in	in	ADP
fnp-2911	165	4	fig	fig	NOUN
fnp-2911	165	5	3a	3a	NUM
fnp-2911	165	6	,	,	PUNCT
fnp-2911	165	7	neurons	neuron	NOUN
fnp-2911	165	8	with	with	ADP
fnp-2911	165	9	tdp-43	tdp-43	PROPN
fnp-2911	165	10	pathology	pathology	NOUN
fnp-2911	165	11	including	include	VERB
fnp-2911	165	12	loss	loss	NOUN
fnp-2911	165	13	of	of	ADP
fnp-2911	165	14	nuclear	nuclear	ADJ
fnp-2911	165	15	tdp-43	tdp-43	PROPN
fnp-2911	165	16	(	(	PUNCT
fnp-2911	165	17	white	white	ADJ
fnp-2911	165	18	)	)	PUNCT
fnp-2911	165	19	are	be	AUX
fnp-2911	165	20	depleted	deplete	VERB
fnp-2911	165	21	in	in	ADP
fnp-2911	165	22	c9orf72	c9orf72	ADJ
fnp-2911	165	23	expansion	expansion	NOUN
fnp-2911	165	24	cases	case	NOUN
fnp-2911	165	25	,	,	PUNCT
fnp-2911	165	26	while	while	SCONJ
fnp-2911	165	27	control	control	NOUN
fnp-2911	165	28	brains	brain	NOUN
fnp-2911	165	29	have	have	VERB
fnp-2911	165	30	the	the	DET
fnp-2911	165	31	normal	normal	ADJ
fnp-2911	165	32	complement	complement	NOUN
fnp-2911	165	33	of	of	ADP
fnp-2911	165	34	neurons	neuron	NOUN
fnp-2911	165	35	(	(	PUNCT
fnp-2911	165	36	blue	blue	ADJ
fnp-2911	165	37	,	,	PUNCT
fnp-2911	165	38	fig	fig	NOUN
fnp-2911	165	39	3b	3b	NUM
fnp-2911	165	40	)	)	PUNCT
fnp-2911	165	41	.	.	PUNCT
fnp-2911	166	1	as	as	ADP
fnp-2911	166	2	a	a	DET
fnp-2911	166	3	result	result	NOUN
fnp-2911	166	4	,	,	PUNCT
fnp-2911	166	5	we	we	PRON
fnp-2911	166	6	hypothesized	hypothesize	VERB
fnp-2911	166	7	that	that	SCONJ
fnp-2911	166	8	the	the	DET
fnp-2911	166	9	depletion	depletion	NOUN
fnp-2911	166	10	of	of	ADP
fnp-2911	166	11	diseased	diseased	ADJ
fnp-2911	166	12	nuclei	nucleus	NOUN
fnp-2911	166	13	would	would	AUX
fnp-2911	166	14	contribute	contribute	VERB
fnp-2911	166	15	to	to	ADP
fnp-2911	166	16	the	the	DET
fnp-2911	166	17	transcriptomic	transcriptomic	ADJ
fnp-2911	166	18	alterations	alteration	NOUN
fnp-2911	166	19	associated	associate	VERB
fnp-2911	166	20	with	with	ADP
fnp-2911	166	21	the	the	DET
fnp-2911	166	22	c9orf72	c9orf72	PROPN
fnp-2911	166	23	mutation	mutation	NOUN
fnp-2911	166	24	.	.	PUNCT
fnp-2911	167	1	thus	thus	ADV
fnp-2911	167	2	,	,	PUNCT
fnp-2911	167	3	we	we	PRON
fnp-2911	167	4	expected	expect	VERB
fnp-2911	167	5	that	that	SCONJ
fnp-2911	167	6	common	common	ADJ
fnp-2911	167	7	genes	gene	NOUN
fnp-2911	167	8	that	that	PRON
fnp-2911	167	9	were	be	AUX
fnp-2911	167	10	downregulated	downregulate	VERB
fnp-2911	167	11	in	in	ADP
fnp-2911	167	12	c9orf72	c9orf72	ADJ
fnp-2911	167	13	expansion	expansion	NOUN
fnp-2911	167	14	cases	case	NOUN
fnp-2911	167	15	would	would	AUX
fnp-2911	167	16	be	be	AUX
fnp-2911	167	17	upregulated	upregulate	VERB
fnp-2911	167	18	in	in	ADP
fnp-2911	167	19	nuclei	nucleus	NOUN
fnp-2911	167	20	without	without	ADP
fnp-2911	167	21	tdp-43	tdp-43	NOUN
fnp-2911	167	22	and	and	CCONJ
fnp-2911	167	23	vice	vice	NOUN
fnp-2911	167	24	versa	versa	ADV
fnp-2911	167	25	.	.	PUNCT
fnp-2911	168	1	indeed	indeed	ADV
fnp-2911	168	2	,	,	PUNCT
fnp-2911	168	3	among	among	ADP
fnp-2911	168	4	the	the	DET
fnp-2911	168	5	118	118	NUM
fnp-2911	168	6	common	common	ADJ
fnp-2911	168	7	significant	significant	ADJ
fnp-2911	168	8	differentially	differentially	ADV
fnp-2911	168	9	expressed	express	VERB
fnp-2911	168	10	genes	gene	NOUN
fnp-2911	168	11	linked	link	VERB
fnp-2911	168	12	to	to	ADP
fnp-2911	168	13	tdp-43	tdp-43	NOUN
fnp-2911	168	14	loss	loss	NOUN
fnp-2911	168	15	(	(	PUNCT
fnp-2911	168	16	52	52	NUM
fnp-2911	168	17	)	)	PUNCT
fnp-2911	168	18	and	and	CCONJ
fnp-2911	168	19	the	the	DET
fnp-2911	168	20	c9orf72	c9orf72	PROPN
fnp-2911	168	21	mutation	mutation	NOUN
fnp-2911	168	22	,	,	PUNCT
fnp-2911	168	23	a	a	DET
fnp-2911	168	24	majority	majority	NOUN
fnp-2911	168	25	of	of	ADP
fnp-2911	168	26	them	they	PRON
fnp-2911	168	27	were	be	AUX
fnp-2911	168	28	followed	follow	VERB
fnp-2911	168	29	this	this	DET
fnp-2911	168	30	pattern	pattern	NOUN
fnp-2911	168	31	(	(	PUNCT
fnp-2911	168	32	fig	fig	NOUN
fnp-2911	168	33	3c	3c	NUM
fnp-2911	168	34	,	,	PUNCT
fnp-2911	168	35	supplemental	supplemental	ADJ
fnp-2911	168	36	table	table	NOUN
fnp-2911	168	37	3	3	NUM
fnp-2911	168	38	)	)	PUNCT
fnp-2911	168	39	.	.	PUNCT
fnp-2911	169	1	a	a	DET
fnp-2911	169	2	linear	linear	ADJ
fnp-2911	169	3	regression	regression	NOUN
fnp-2911	169	4	analysis	analysis	NOUN
fnp-2911	169	5	showed	show	VERB
fnp-2911	169	6	there	there	PRON
fnp-2911	169	7	was	be	VERB
fnp-2911	169	8	a	a	DET
fnp-2911	169	9	negative	negative	ADJ
fnp-2911	169	10	correlation	correlation	NOUN
fnp-2911	169	11	between	between	ADP
fnp-2911	169	12	the	the	DET
fnp-2911	169	13	gene	gene	NOUN
fnp-2911	169	14	fold	fold	NOUN
fnp-2911	169	15	change	change	NOUN
fnp-2911	169	16	linked	link	VERB
fnp-2911	169	17	to	to	ADP
fnp-2911	169	18	tdp-43	tdp-43	NOUN
fnp-2911	169	19	loss	loss	NOUN
fnp-2911	169	20	and	and	CCONJ
fnp-2911	169	21	the	the	DET
fnp-2911	169	22	gene	gene	NOUN
fnp-2911	169	23	fold	fold	NOUN
fnp-2911	169	24	change	change	NOUN
fnp-2911	169	25	linked	link	VERB
fnp-2911	169	26	to	to	ADP
fnp-2911	169	27	the	the	DET
fnp-2911	169	28	c9orf72	c9orf72	PROPN
fnp-2911	169	29	mutation	mutation	NOUN
fnp-2911	169	30	(	(	PUNCT
fnp-2911	169	31	pearson	pearson	PROPN
fnp-2911	169	32	’s	’s	PART
fnp-2911	169	33	r=-0.5708	r=-0.5708	PROPN
fnp-2911	169	34	;	;	PUNCT
fnp-2911	169	35	p<0.0001	p<0.0001	PRON
fnp-2911	169	36	)	)	PUNCT
fnp-2911	169	37	.	.	PUNCT
fnp-2911	170	1	furthermore	furthermore	ADV
fnp-2911	170	2	,	,	PUNCT
fnp-2911	170	3	this	this	DET
fnp-2911	170	4	relationship	relationship	NOUN
fnp-2911	170	5	was	be	AUX
fnp-2911	170	6	extended	extend	VERB
fnp-2911	170	7	transcriptome	transcriptome	NOUN
fnp-2911	170	8	-	-	PUNCT
fnp-2911	170	9	wide	wide	ADJ
fnp-2911	170	10	where	where	SCONJ
fnp-2911	170	11	we	we	PRON
fnp-2911	170	12	observed	observe	VERB
fnp-2911	170	13	a	a	DET
fnp-2911	170	14	negative	negative	ADJ
fnp-2911	170	15	correlation	correlation	NOUN
fnp-2911	170	16	in	in	ADP
fnp-2911	170	17	all	all	DET
fnp-2911	170	18	commonly	commonly	ADV
fnp-2911	170	19	expressed	express	VERB
fnp-2911	170	20	genes	gene	NOUN
fnp-2911	170	21	derived	derive	VERB
fnp-2911	170	22	from	from	ADP
fnp-2911	170	23	both	both	DET
fnp-2911	170	24	data	datum	NOUN
fnp-2911	170	25	sets	set	NOUN
fnp-2911	170	26	(	(	PUNCT
fnp-2911	170	27	fig	fig	NOUN
fnp-2911	170	28	3d	3d	NOUN
fnp-2911	170	29	)	)	PUNCT
fnp-2911	170	30	.	.	PUNCT
fnp-2911	171	1	for	for	ADP
fnp-2911	171	2	example	example	NOUN
fnp-2911	171	3	,	,	PUNCT
fnp-2911	171	4	igsf11	igsf11	NOUN
fnp-2911	171	5	and	and	CCONJ
fnp-2911	171	6	pvrl3	pvrl3	NOUN
fnp-2911	171	7	expression	expression	NOUN
fnp-2911	171	8	,	,	PUNCT
fnp-2911	171	9	preferentially	preferentially	ADV
fnp-2911	171	10	observed	observe	VERB
fnp-2911	171	11	in	in	ADP
fnp-2911	171	12	superficial	superficial	ADJ
fnp-2911	171	13	neocortical	neocortical	ADJ
fnp-2911	171	14	layers	layer	NOUN
fnp-2911	171	15	and	and	CCONJ
fnp-2911	171	16	therefore	therefore	ADV
fnp-2911	171	17	increased	increase	VERB
fnp-2911	171	18	in	in	ADP
fnp-2911	171	19	neuronal	neuronal	ADJ
fnp-2911	171	20	nuclei	nucleus	NOUN
fnp-2911	171	21	without	without	ADP
fnp-2911	171	22	tdp-43	tdp-43	NOUN
fnp-2911	171	23	protein	protein	NOUN
fnp-2911	171	24	(	(	PUNCT
fnp-2911	171	25	52	52	NUM
fnp-2911	171	26	)	)	PUNCT
fnp-2911	171	27	,	,	PUNCT
fnp-2911	171	28	is	be	AUX
fnp-2911	171	29	significantly	significantly	ADV
fnp-2911	171	30	reduced	reduce	VERB
fnp-2911	171	31	in	in	ADP
fnp-2911	171	32	the	the	DET
fnp-2911	171	33	c9orf72	c9orf72	PROPN
fnp-2911	171	34	transcriptome	transcriptome	PROPN
fnp-2911	171	35	.	.	PUNCT
fnp-2911	172	1	conversely	conversely	ADV
fnp-2911	172	2	,	,	PUNCT
fnp-2911	172	3	syt6	syt6	ADJ
fnp-2911	172	4	and	and	CCONJ
fnp-2911	172	5	col6a1	col6a1	NOUN
fnp-2911	172	6	expression	expression	NOUN
fnp-2911	172	7	,	,	PUNCT
fnp-2911	172	8	preferentially	preferentially	ADV
fnp-2911	172	9	observed	observe	VERB
fnp-2911	172	10	in	in	ADP
fnp-2911	172	11	deep	deep	ADJ
fnp-2911	172	12	neocortical	neocortical	ADJ
fnp-2911	172	13	layers	layer	NOUN
fnp-2911	172	14	and	and	CCONJ
fnp-2911	172	15	therefore	therefore	ADV
fnp-2911	172	16	decreased	decrease	VERB
fnp-2911	172	17	in	in	ADP
fnp-2911	172	18	neuronal	neuronal	ADJ
fnp-2911	172	19	nuclei	nucleus	NOUN
fnp-2911	172	20	without	without	ADP
fnp-2911	172	21	tdp-43	tdp-43	NOUN
fnp-2911	172	22	protein	protein	NOUN
fnp-2911	172	23	(	(	PUNCT
fnp-2911	172	24	52	52	NUM
fnp-2911	172	25	)	)	PUNCT
fnp-2911	172	26	,	,	PUNCT
fnp-2911	172	27	is	be	AUX
fnp-2911	172	28	significantly	significantly	ADV
fnp-2911	172	29	increased	increase	VERB
fnp-2911	172	30	in	in	ADP
fnp-2911	172	31	the	the	DET
fnp-2911	172	32	c9orf72	c9orf72	PROPN
fnp-2911	172	33	transcriptome	transcriptome	PROPN
fnp-2911	172	34	.	.	PUNCT
fnp-2911	173	1	this	this	PRON
fnp-2911	173	2	suggested	suggest	VERB
fnp-2911	173	3	that	that	SCONJ
fnp-2911	173	4	depletion	depletion	NOUN
fnp-2911	173	5	of	of	ADP
fnp-2911	173	6	the	the	DET
fnp-2911	173	7	diseased	diseased	ADJ
fnp-2911	173	8	nuclei	nucleus	NOUN
fnp-2911	173	9	in	in	ADP
fnp-2911	173	10	c9orf72	c9orf72	ADJ
fnp-2911	173	11	expansion	expansion	NOUN
fnp-2911	173	12	cases	case	NOUN
fnp-2911	173	13	may	may	AUX
fnp-2911	173	14	explain	explain	VERB
fnp-2911	173	15	some	some	PRON
fnp-2911	173	16	of	of	ADP
fnp-2911	173	17	the	the	DET
fnp-2911	173	18	transcriptomic	transcriptomic	ADJ
fnp-2911	173	19	alterations	alteration	NOUN
fnp-2911	173	20	observed	observe	VERB
fnp-2911	173	21	in	in	ADP
fnp-2911	173	22	c9orf72	c9orf72	ADJ
fnp-2911	173	23	expansion	expansion	NOUN
fnp-2911	173	24	cases	case	NOUN
fnp-2911	173	25	.	.	PUNCT
fnp-2911	174	1	fig	fig	NOUN
fnp-2911	174	2	3	3	NUM
fnp-2911	174	3	:	:	PUNCT
fnp-2911	175	1	c9orf72	c9orf72	ADJ
fnp-2911	175	2	transcriptome	transcriptome	NOUN
fnp-2911	175	3	is	be	AUX
fnp-2911	175	4	linked	link	VERB
fnp-2911	175	5	to	to	ADP
fnp-2911	175	6	depletion	depletion	NOUN
fnp-2911	175	7	of	of	ADP
fnp-2911	175	8	tdp-43	tdp-43	NUM
fnp-2911	175	9	pathologic	pathologic	ADJ
fnp-2911	175	10	nuclei	nucleus	NOUN
fnp-2911	175	11	.	.	PUNCT
fnp-2911	176	1	(	(	PUNCT
fnp-2911	176	2	a	a	X
fnp-2911	176	3	)	)	PUNCT
fnp-2911	176	4	in	in	ADP
fnp-2911	176	5	c9orf72	c9orf72	ADJ
fnp-2911	176	6	expansion	expansion	NOUN
fnp-2911	176	7	cases	case	NOUN
fnp-2911	176	8	,	,	PUNCT
fnp-2911	176	9	there	there	PRON
fnp-2911	176	10	are	be	VERB
fnp-2911	176	11	nuclei	nucleus	NOUN
fnp-2911	176	12	with	with	ADP
fnp-2911	176	13	tdp-43	tdp-43	PROPN
fnp-2911	176	14	(	(	PUNCT
fnp-2911	176	15	blue	blue	ADJ
fnp-2911	176	16	)	)	PUNCT
fnp-2911	176	17	and	and	CCONJ
fnp-2911	176	18	those	those	PRON
fnp-2911	176	19	without	without	ADP
fnp-2911	176	20	tdp-43	tdp-43	PROPN
fnp-2911	176	21	(	(	PUNCT
fnp-2911	176	22	white	white	ADJ
fnp-2911	176	23	)	)	PUNCT
fnp-2911	176	24	.	.	PUNCT
fnp-2911	177	1	for	for	ADP
fnp-2911	177	2	our	our	PRON
fnp-2911	177	3	transcriptome	transcriptome	ADJ
fnp-2911	177	4	analysis	analysis	NOUN
fnp-2911	177	5	,	,	PUNCT
fnp-2911	177	6	only	only	ADV
fnp-2911	177	7	nuclei	nucleus	NOUN
fnp-2911	177	8	with	with	ADP
fnp-2911	177	9	tdp-43	tdp-43	NOUN
fnp-2911	177	10	were	be	AUX
fnp-2911	177	11	collected	collect	VERB
fnp-2911	177	12	(	(	PUNCT
fnp-2911	177	13	red	red	PROPN
fnp-2911	177	14	box	box	PROPN
fnp-2911	177	15	)	)	PUNCT
fnp-2911	177	16	,	,	PUNCT
fnp-2911	177	17	thereby	thereby	ADV
fnp-2911	177	18	depleting	deplete	VERB
fnp-2911	177	19	nuclei	nucleus	NOUN
fnp-2911	177	20	without	without	ADP
fnp-2911	177	21	tdp-43	tdp-43	PROPN
fnp-2911	177	22	.	.	PUNCT
fnp-2911	178	1	(	(	PUNCT
fnp-2911	178	2	b	b	X
fnp-2911	178	3	)	)	PUNCT
fnp-2911	178	4	in	in	ADP
fnp-2911	178	5	non	non	ADJ
fnp-2911	178	6	-	-	ADJ
fnp-2911	178	7	diseased	diseased	ADJ
fnp-2911	178	8	controls	control	NOUN
fnp-2911	178	9	,	,	PUNCT
fnp-2911	178	10	nuclei	nucleus	NOUN
fnp-2911	178	11	with	with	ADP
fnp-2911	178	12	tdp-43	tdp-43	NOUN
fnp-2911	178	13	were	be	AUX
fnp-2911	178	14	collected	collect	VERB
fnp-2911	178	15	(	(	PUNCT
fnp-2911	178	16	red	red	PROPN
fnp-2911	178	17	box	box	PROPN
fnp-2911	178	18	)	)	PUNCT
fnp-2911	178	19	.	.	PUNCT
fnp-2911	179	1	(	(	PUNCT
fnp-2911	179	2	c	c	X
fnp-2911	179	3	)	)	PUNCT
fnp-2911	179	4	gene	gene	NOUN
fnp-2911	179	5	fold	fold	NOUN
fnp-2911	179	6	changes	change	NOUN
fnp-2911	179	7	of	of	ADP
fnp-2911	179	8	genes	gene	NOUN
fnp-2911	179	9	that	that	PRON
fnp-2911	179	10	were	be	AUX
fnp-2911	179	11	common	common	ADJ
fnp-2911	179	12	significant	significant	ADJ
fnp-2911	179	13	differentially	differentially	ADV
fnp-2911	179	14	expressed	express	VERB
fnp-2911	179	15	linked	link	VERB
fnp-2911	179	16	to	to	ADP
fnp-2911	179	17	tdp-43	tdp-43	NOUN
fnp-2911	179	18	loss	loss	NOUN
fnp-2911	179	19	and	and	CCONJ
fnp-2911	179	20	the	the	DET
fnp-2911	179	21	c9orf72	c9orf72	PROPN
fnp-2911	179	22	mutation	mutation	NOUN
fnp-2911	179	23	were	be	AUX
fnp-2911	179	24	plotted	plot	VERB
fnp-2911	179	25	,	,	PUNCT
fnp-2911	179	26	showing	show	VERB
fnp-2911	179	27	that	that	SCONJ
fnp-2911	179	28	genes	gene	NOUN
fnp-2911	179	29	that	that	PRON
fnp-2911	179	30	were	be	AUX
fnp-2911	179	31	downregulated	downregulate	VERB
fnp-2911	179	32	due	due	ADP
fnp-2911	179	33	to	to	ADP
fnp-2911	179	34	the	the	DET
fnp-2911	179	35	c9orf72	c9orf72	PROPN
fnp-2911	179	36	mutation	mutation	NOUN
fnp-2911	179	37	were	be	AUX
fnp-2911	179	38	upregulated	upregulate	VERB
fnp-2911	179	39	due	due	ADP
fnp-2911	179	40	to	to	ADP
fnp-2911	179	41	tdp-43	tdp-43	PROPN
fnp-2911	179	42	loss	loss	NOUN
fnp-2911	179	43	,	,	PUNCT
fnp-2911	179	44	suggesting	suggest	VERB
fnp-2911	179	45	that	that	DET
fnp-2911	179	46	depletion	depletion	NOUN
fnp-2911	179	47	of	of	ADP
fnp-2911	179	48	diseased	diseased	ADJ
fnp-2911	179	49	nuclei	nucleus	NOUN
fnp-2911	179	50	(	(	PUNCT
fnp-2911	179	51	without	without	ADP
fnp-2911	179	52	tdp-43	tdp-43	NOUN
fnp-2911	179	53	)	)	PUNCT
fnp-2911	179	54	can	can	AUX
fnp-2911	179	55	partially	partially	ADV
fnp-2911	179	56	explain	explain	VERB
fnp-2911	179	57	the	the	DET
fnp-2911	179	58	transcriptomic	transcriptomic	ADJ
fnp-2911	179	59	changes	change	NOUN
fnp-2911	179	60	observed	observe	VERB
fnp-2911	179	61	in	in	ADP
fnp-2911	179	62	this	this	DET
fnp-2911	179	63	dataset	dataset	NOUN
fnp-2911	179	64	(	(	PUNCT
fnp-2911	179	65	pearson	pearson	PROPN
fnp-2911	179	66	’s	’s	PART
fnp-2911	179	67	r=-0.5708	r=-0.5708	PROPN
fnp-2911	179	68	,	,	PUNCT
fnp-2911	179	69	p<0.0001	p<0.0001	NOUN
fnp-2911	179	70	)	)	PUNCT
fnp-2911	179	71	.	.	PUNCT
fnp-2911	180	1	(	(	PUNCT
fnp-2911	180	2	d	d	X
fnp-2911	180	3	)	)	PUNCT
fnp-2911	180	4	genome	genome	NOUN
fnp-2911	180	5	-	-	PUNCT
fnp-2911	180	6	wide	wide	ADJ
fnp-2911	180	7	gene	gene	NOUN
fnp-2911	180	8	fold	fold	NOUN
fnp-2911	180	9	changes	change	NOUN
fnp-2911	180	10	that	that	PRON
fnp-2911	180	11	were	be	AUX
fnp-2911	180	12	expressed	express	VERB
fnp-2911	180	13	in	in	ADP
fnp-2911	180	14	both	both	DET
fnp-2911	180	15	datasets	dataset	NOUN
fnp-2911	180	16	linked	link	VERB
fnp-2911	180	17	to	to	ADP
fnp-2911	180	18	tdp-43	tdp-43	NOUN
fnp-2911	180	19	loss	loss	NOUN
fnp-2911	180	20	and	and	CCONJ
fnp-2911	180	21	c9orf72	c9orf72	ADJ
fnp-2911	180	22	mutation	mutation	NOUN
fnp-2911	180	23	showed	show	VERB
fnp-2911	180	24	a	a	DET
fnp-2911	180	25	similar	similar	ADJ
fnp-2911	180	26	pattern	pattern	NOUN
fnp-2911	180	27	.	.	PUNCT
fnp-2911	181	1	global	global	ADJ
fnp-2911	181	2	c9orf72	c9orf72	PROPN
fnp-2911	181	3	associated	associate	VERB
fnp-2911	181	4	transcriptome	transcriptome	ADJ
fnp-2911	181	5	changes	change	NOUN
fnp-2911	181	6	are	be	AUX
fnp-2911	181	7	linked	link	VERB
fnp-2911	181	8	to	to	ADP
fnp-2911	181	9	loss	loss	NOUN
fnp-2911	181	10	of	of	ADP
fnp-2911	181	11	function	function	NOUN
fnp-2911	181	12	of	of	ADP
fnp-2911	181	13	the	the	DET
fnp-2911	181	14	c9orf72	c9orf72	ADJ
fnp-2911	181	15	protein	protein	NOUN
fnp-2911	181	16	current	current	ADJ
fnp-2911	181	17	hypotheses	hypothesis	NOUN
fnp-2911	181	18	of	of	ADP
fnp-2911	181	19	c9orf72	c9orf72	ADJ
fnp-2911	181	20	toxicity	toxicity	NOUN
fnp-2911	181	21	include	include	VERB
fnp-2911	181	22	loss	loss	NOUN
fnp-2911	181	23	of	of	ADP
fnp-2911	181	24	c9orf72	c9orf72	ADJ
fnp-2911	181	25	protein	protein	NOUN
fnp-2911	181	26	or	or	CCONJ
fnp-2911	181	27	gain	gain	NOUN
fnp-2911	181	28	of	of	ADP
fnp-2911	181	29	toxic	toxic	ADJ
fnp-2911	181	30	rna	rna	NOUN
fnp-2911	181	31	foci	focus	NOUN
fnp-2911	181	32	and	and	CCONJ
fnp-2911	181	33	dipeptide	dipeptide	NOUN
fnp-2911	181	34	repeat	repeat	NOUN
fnp-2911	181	35	aggregates	aggregate	NOUN
fnp-2911	181	36	(	(	PUNCT
fnp-2911	181	37	9	9	NUM
fnp-2911	181	38	)	)	PUNCT
fnp-2911	181	39	.	.	PUNCT
fnp-2911	182	1	while	while	SCONJ
fnp-2911	182	2	some	some	DET
fnp-2911	182	3	transcriptome	transcriptome	ADJ
fnp-2911	182	4	changes	change	NOUN
fnp-2911	182	5	which	which	PRON
fnp-2911	182	6	appear	appear	VERB
fnp-2911	182	7	to	to	PART
fnp-2911	182	8	be	be	AUX
fnp-2911	182	9	related	relate	VERB
fnp-2911	182	10	to	to	ADP
fnp-2911	182	11	c9orf72	c9orf72	ADJ
fnp-2911	182	12	gain	gain	NOUN
fnp-2911	182	13	of	of	ADP
fnp-2911	182	14	toxic	toxic	ADJ
fnp-2911	182	15	function	function	NOUN
fnp-2911	182	16	(	(	PUNCT
fnp-2911	182	17	genes	gene	NOUN
fnp-2911	182	18	associated	associate	VERB
fnp-2911	182	19	with	with	ADP
fnp-2911	182	20	proteostasis	proteostasis	NOUN
fnp-2911	182	21	and	and	CCONJ
fnp-2911	182	22	dna	dna	NOUN
fnp-2911	182	23	damage	damage	NOUN
fnp-2911	182	24	,	,	PUNCT
fnp-2911	182	25	dysregulation	dysregulation	NOUN
fnp-2911	182	26	of	of	ADP
fnp-2911	182	27	transcripts	transcript	NOUN
fnp-2911	182	28	with	with	ADP
fnp-2911	182	29	hnrnp	hnrnp	PROPN
fnp-2911	182	30	3’utr	3’utr	NUM
fnp-2911	182	31	binding	bind	VERB
fnp-2911	182	32	sites	site	NOUN
fnp-2911	182	33	)	)	PUNCT
fnp-2911	182	34	,	,	PUNCT
fnp-2911	182	35	other	other	ADJ
fnp-2911	182	36	changes	change	NOUN
fnp-2911	182	37	appeared	appear	VERB
fnp-2911	182	38	to	to	PART
fnp-2911	182	39	be	be	AUX
fnp-2911	182	40	linked	link	VERB
fnp-2911	182	41	to	to	ADP
fnp-2911	182	42	the	the	DET
fnp-2911	182	43	loss	loss	NOUN
fnp-2911	182	44	of	of	ADP
fnp-2911	182	45	c9orf72	c9orf72	ADJ
fnp-2911	182	46	protein	protein	NOUN
fnp-2911	182	47	(	(	PUNCT
fnp-2911	182	48	genes	gene	NOUN
fnp-2911	182	49	associated	associate	VERB
fnp-2911	182	50	with	with	ADP
fnp-2911	182	51	vesicle	vesicle	NOUN
fnp-2911	182	52	membranes	membrane	NOUN
fnp-2911	182	53	and	and	CCONJ
fnp-2911	182	54	endosomal	endosomal	ADJ
fnp-2911	182	55	trafficking	trafficking	NOUN
fnp-2911	182	56	)	)	PUNCT
fnp-2911	182	57	.	.	PUNCT
fnp-2911	183	1	however	however	ADV
fnp-2911	183	2	,	,	PUNCT
fnp-2911	183	3	at	at	ADP
fnp-2911	183	4	a	a	DET
fnp-2911	183	5	global	global	ADJ
fnp-2911	183	6	transcriptome	transcriptome	ADJ
fnp-2911	183	7	level	level	NOUN
fnp-2911	183	8	,	,	PUNCT
fnp-2911	183	9	it	it	PRON
fnp-2911	183	10	was	be	AUX
fnp-2911	183	11	unclear	unclear	ADJ
fnp-2911	183	12	whether	whether	SCONJ
fnp-2911	183	13	the	the	DET
fnp-2911	183	14	overall	overall	ADJ
fnp-2911	183	15	changes	change	NOUN
fnp-2911	183	16	associated	associate	VERB
fnp-2911	183	17	with	with	ADP
fnp-2911	183	18	the	the	DET
fnp-2911	183	19	mutation	mutation	NOUN
fnp-2911	183	20	reflect	reflect	VERB
fnp-2911	183	21	changes	change	NOUN
fnp-2911	183	22	linked	link	VERB
fnp-2911	183	23	to	to	ADP
fnp-2911	183	24	a	a	DET
fnp-2911	183	25	toxic	toxic	ADJ
fnp-2911	183	26	gain	gain	NOUN
fnp-2911	183	27	of	of	ADP
fnp-2911	183	28	c9orf72	c9orf72	ADJ
fnp-2911	183	29	function	function	NOUN
fnp-2911	183	30	or	or	CCONJ
fnp-2911	183	31	the	the	DET
fnp-2911	183	32	loss	loss	NOUN
fnp-2911	183	33	of	of	ADP
fnp-2911	183	34	c9orf72	c9orf72	ADJ
fnp-2911	183	35	protein	protein	NOUN
fnp-2911	183	36	.	.	PUNCT
fnp-2911	184	1	c9orf72	c9orf72	PROPN
fnp-2911	184	2	rna	rna	PROPN
fnp-2911	184	3	foci	focus	NOUN
fnp-2911	184	4	and	and	CCONJ
fnp-2911	184	5	dipeptide	dipeptide	NOUN
fnp-2911	184	6	repeat	repeat	NOUN
fnp-2911	184	7	protein	protein	NOUN
fnp-2911	184	8	aggregates	aggregate	NOUN
fnp-2911	184	9	are	be	AUX
fnp-2911	184	10	seen	see	VERB
fnp-2911	184	11	in	in	ADP
fnp-2911	184	12	c9orf72	c9orf72	PROPN
fnp-2911	184	13	repeat	repeat	NOUN
fnp-2911	184	14	expansion	expansion	NOUN
fnp-2911	184	15	carriers	carrier	NOUN
fnp-2911	184	16	but	but	CCONJ
fnp-2911	184	17	absent	absent	ADJ
fnp-2911	184	18	in	in	ADP
fnp-2911	184	19	neurologically	neurologically	ADV
fnp-2911	184	20	normal	normal	ADJ
fnp-2911	184	21	controls	control	NOUN
fnp-2911	184	22	.	.	PUNCT
fnp-2911	185	1	we	we	PRON
fnp-2911	185	2	have	have	AUX
fnp-2911	185	3	also	also	ADV
fnp-2911	185	4	demonstrated	demonstrate	VERB
fnp-2911	185	5	that	that	SCONJ
fnp-2911	185	6	within	within	ADP
fnp-2911	185	7	c9orf72	c9orf72	ADJ
fnp-2911	185	8	mutation	mutation	NOUN
fnp-2911	185	9	carriers	carrier	NOUN
fnp-2911	185	10	,	,	PUNCT
fnp-2911	185	11	c9orf72	c9orf72	ADJ
fnp-2911	185	12	promoter	promoter	NOUN
fnp-2911	185	13	methylation	methylation	NOUN
fnp-2911	185	14	is	be	AUX
fnp-2911	185	15	negatively	negatively	ADV
fnp-2911	185	16	correlated	correlate	VERB
fnp-2911	185	17	with	with	ADP
fnp-2911	185	18	the	the	DET
fnp-2911	185	19	accumulation	accumulation	NOUN
fnp-2911	185	20	of	of	ADP
fnp-2911	185	21	rna	rna	NOUN
fnp-2911	185	22	foci	focus	NOUN
fnp-2911	185	23	and	and	CCONJ
fnp-2911	185	24	dipeptide	dipeptide	NOUN
fnp-2911	185	25	repeat	repeat	NOUN
fnp-2911	185	26	protein	protein	NOUN
fnp-2911	185	27	aggregates	aggregate	NOUN
fnp-2911	185	28	in	in	ADP
fnp-2911	185	29	human	human	ADJ
fnp-2911	185	30	brains	brain	NOUN
fnp-2911	185	31	(	(	PUNCT
fnp-2911	185	32	43	43	NUM
fnp-2911	185	33	-	-	SYM
fnp-2911	185	34	45	45	NUM
fnp-2911	185	35	)	)	PUNCT
fnp-2911	185	36	.	.	PUNCT
fnp-2911	186	1	based	base	VERB
fnp-2911	186	2	on	on	ADP
fnp-2911	186	3	this	this	PRON
fnp-2911	186	4	,	,	PUNCT
fnp-2911	186	5	we	we	PRON
fnp-2911	186	6	developed	develop	VERB
fnp-2911	186	7	a	a	DET
fnp-2911	186	8	theoretical	theoretical	ADJ
fnp-2911	186	9	framework	framework	NOUN
fnp-2911	186	10	(	(	PUNCT
fnp-2911	186	11	fig	fig	NOUN
fnp-2911	186	12	4a	4a	NOUN
fnp-2911	186	13	-	-	PUNCT
fnp-2911	186	14	d	d	NOUN
fnp-2911	186	15	)	)	PUNCT
fnp-2911	186	16	wherein	wherein	SCONJ
fnp-2911	186	17	statistical	statistical	ADJ
fnp-2911	186	18	analysis	analysis	NOUN
fnp-2911	186	19	was	be	AUX
fnp-2911	186	20	performed	perform	VERB
fnp-2911	186	21	within	within	ADP
fnp-2911	186	22	c9orf72	c9orf72	ADJ
fnp-2911	186	23	expansion	expansion	NOUN
fnp-2911	186	24	cases	case	NOUN
fnp-2911	186	25	versus	versus	ADP
fnp-2911	186	26	statistical	statistical	ADJ
fnp-2911	186	27	analysis	analysis	NOUN
fnp-2911	186	28	between	between	ADP
fnp-2911	186	29	c9orf72	c9orf72	ADJ
fnp-2911	186	30	expansion	expansion	NOUN
fnp-2911	186	31	cases	case	NOUN
fnp-2911	186	32	and	and	CCONJ
fnp-2911	186	33	controls	control	NOUN
fnp-2911	186	34	.	.	PUNCT
fnp-2911	187	1	as	as	ADP
fnp-2911	187	2	a	a	DET
fnp-2911	187	3	theoretical	theoretical	ADJ
fnp-2911	187	4	example	example	NOUN
fnp-2911	187	5	,	,	PUNCT
fnp-2911	187	6	using	use	VERB
fnp-2911	187	7	c9orf72	c9orf72	PROPN
fnp-2911	187	8	itself	itself	PRON
fnp-2911	187	9	as	as	ADP
fnp-2911	187	10	a	a	DET
fnp-2911	187	11	gene	gene	NOUN
fnp-2911	187	12	that	that	PRON
fnp-2911	187	13	contributes	contribute	VERB
fnp-2911	187	14	to	to	ADP
fnp-2911	187	15	the	the	DET
fnp-2911	187	16	loss	loss	NOUN
fnp-2911	187	17	of	of	ADP
fnp-2911	187	18	c9orf72	c9orf72	ADJ
fnp-2911	187	19	protein	protein	NOUN
fnp-2911	187	20	,	,	PUNCT
fnp-2911	187	21	we	we	PRON
fnp-2911	187	22	predicted	predict	VERB
fnp-2911	187	23	that	that	SCONJ
fnp-2911	187	24	within	within	ADP
fnp-2911	187	25	c9orf72	c9orf72	ADJ
fnp-2911	187	26	expansion	expansion	NOUN
fnp-2911	187	27	carriers	carrier	NOUN
fnp-2911	187	28	,	,	PUNCT
fnp-2911	187	29	methylation	methylation	NOUN
fnp-2911	187	30	of	of	ADP
fnp-2911	187	31	the	the	DET
fnp-2911	187	32	c9orf72	c9orf72	PROPN
fnp-2911	187	33	promoter	promoter	NOUN
fnp-2911	187	34	would	would	AUX
fnp-2911	187	35	negatively	negatively	ADV
fnp-2911	187	36	correlate	correlate	VERB
fnp-2911	187	37	with	with	ADP
fnp-2911	187	38	c9orf72	c9orf72	ADJ
fnp-2911	187	39	expression	expression	NOUN
fnp-2911	187	40	(	(	PUNCT
fnp-2911	187	41	fig	fig	NOUN
fnp-2911	187	42	4a	4a	NOUN
fnp-2911	187	43	)	)	PUNCT
fnp-2911	187	44	.	.	PUNCT
fnp-2911	188	1	moreover	moreover	ADV
fnp-2911	188	2	,	,	PUNCT
fnp-2911	188	3	we	we	PRON
fnp-2911	188	4	predicted	predict	VERB
fnp-2911	188	5	that	that	SCONJ
fnp-2911	188	6	between	between	ADP
fnp-2911	188	7	-	-	PUNCT
fnp-2911	188	8	group	group	NOUN
fnp-2911	188	9	analysis	analysis	NOUN
fnp-2911	188	10	would	would	AUX
fnp-2911	188	11	show	show	VERB
fnp-2911	188	12	that	that	SCONJ
fnp-2911	188	13	c9orf72	c9orf72	ADJ
fnp-2911	188	14	expression	expression	NOUN
fnp-2911	188	15	is	be	AUX
fnp-2911	188	16	downregulated	downregulate	VERB
fnp-2911	188	17	compared	compare	VERB
fnp-2911	188	18	to	to	ADP
fnp-2911	188	19	controls	control	NOUN
fnp-2911	188	20	(	(	PUNCT
fnp-2911	188	21	fig	fig	NOUN
fnp-2911	188	22	4b	4b	PROPN
fnp-2911	188	23	)	)	PUNCT
fnp-2911	188	24	.	.	PUNCT
fnp-2911	189	1	this	this	PRON
fnp-2911	189	2	would	would	AUX
fnp-2911	189	3	be	be	AUX
fnp-2911	189	4	an	an	DET
fnp-2911	189	5	example	example	NOUN
fnp-2911	189	6	of	of	ADP
fnp-2911	189	7	a	a	DET
fnp-2911	189	8	“	"	PUNCT
fnp-2911	189	9	concordant	concordant	ADJ
fnp-2911	189	10	”	"	PUNCT
fnp-2911	189	11	gene	gene	NOUN
fnp-2911	189	12	which	which	PRON
fnp-2911	189	13	provides	provide	VERB
fnp-2911	189	14	evidence	evidence	NOUN
fnp-2911	189	15	that	that	SCONJ
fnp-2911	189	16	the	the	DET
fnp-2911	189	17	altered	alter	VERB
fnp-2911	189	18	gene	gene	NOUN
fnp-2911	189	19	expression	expression	NOUN
fnp-2911	189	20	is	be	AUX
fnp-2911	189	21	linked	link	VERB
fnp-2911	189	22	to	to	ADP
fnp-2911	189	23	the	the	DET
fnp-2911	189	24	loss	loss	NOUN
fnp-2911	189	25	of	of	ADP
fnp-2911	189	26	c9orf72	c9orf72	ADJ
fnp-2911	189	27	protein	protein	NOUN
fnp-2911	189	28	.	.	PUNCT
fnp-2911	190	1	conversely	conversely	ADV
fnp-2911	190	2	,	,	PUNCT
fnp-2911	190	3	using	use	VERB
fnp-2911	190	4	similar	similar	ADJ
fnp-2911	190	5	logic	logic	NOUN
fnp-2911	190	6	,	,	PUNCT
fnp-2911	190	7	if	if	SCONJ
fnp-2911	190	8	a	a	DET
fnp-2911	190	9	gene	gene	NOUN
fnp-2911	190	10	contributes	contribute	VERB
fnp-2911	190	11	to	to	ADP
fnp-2911	190	12	the	the	DET
fnp-2911	190	13	gain	gain	NOUN
fnp-2911	190	14	of	of	ADP
fnp-2911	190	15	toxic	toxic	ADJ
fnp-2911	190	16	function	function	NOUN
fnp-2911	190	17	such	such	ADJ
fnp-2911	190	18	as	as	ADP
fnp-2911	190	19	the	the	DET
fnp-2911	190	20	formation	formation	NOUN
fnp-2911	190	21	of	of	ADP
fnp-2911	190	22	toxic	toxic	ADJ
fnp-2911	190	23	rna	rna	NOUN
fnp-2911	190	24	,	,	PUNCT
fnp-2911	190	25	we	we	PRON
fnp-2911	190	26	would	would	AUX
fnp-2911	190	27	predict	predict	VERB
fnp-2911	190	28	that	that	SCONJ
fnp-2911	190	29	within	within	ADP
fnp-2911	190	30	c9orf72	c9orf72	ADJ
fnp-2911	190	31	expansion	expansion	NOUN
fnp-2911	190	32	carriers	carrier	NOUN
fnp-2911	190	33	,	,	PUNCT
fnp-2911	190	34	methylation	methylation	NOUN
fnp-2911	190	35	of	of	ADP
fnp-2911	190	36	the	the	DET
fnp-2911	190	37	c9orf72	c9orf72	PROPN
fnp-2911	190	38	promoter	promoter	NOUN
fnp-2911	190	39	would	would	AUX
fnp-2911	190	40	negatively	negatively	ADV
fnp-2911	190	41	correlate	correlate	VERB
fnp-2911	190	42	with	with	ADP
fnp-2911	190	43	toxic	toxic	ADJ
fnp-2911	190	44	rna	rna	NOUN
fnp-2911	190	45	(	(	PUNCT
fnp-2911	190	46	fig	fig	NOUN
fnp-2911	190	47	4c	4c	NOUN
fnp-2911	190	48	)	)	PUNCT
fnp-2911	190	49	.	.	PUNCT
fnp-2911	191	1	however	however	ADV
fnp-2911	191	2	,	,	PUNCT
fnp-2911	191	3	between	between	ADP
fnp-2911	191	4	groups	group	NOUN
fnp-2911	191	5	,	,	PUNCT
fnp-2911	191	6	this	this	DET
fnp-2911	191	7	gene	gene	NOUN
fnp-2911	191	8	would	would	AUX
fnp-2911	191	9	be	be	AUX
fnp-2911	191	10	upregulated	upregulate	VERB
fnp-2911	191	11	in	in	ADP
fnp-2911	191	12	c9orf72	c9orf72	ADJ
fnp-2911	191	13	expansion	expansion	NOUN
fnp-2911	191	14	carriers	carrier	NOUN
fnp-2911	191	15	compared	compare	VERB
fnp-2911	191	16	to	to	ADP
fnp-2911	191	17	controls	control	NOUN
fnp-2911	191	18	(	(	PUNCT
fnp-2911	191	19	fig	fig	NOUN
fnp-2911	191	20	4d	4d	NUM
fnp-2911	191	21	)	)	PUNCT
fnp-2911	191	22	.	.	PUNCT
fnp-2911	192	1	this	this	PRON
fnp-2911	192	2	would	would	AUX
fnp-2911	192	3	be	be	AUX
fnp-2911	192	4	an	an	DET
fnp-2911	192	5	example	example	NOUN
fnp-2911	192	6	of	of	ADP
fnp-2911	192	7	a	a	DET
fnp-2911	192	8	“	"	PUNCT
fnp-2911	192	9	discordant	discordant	ADJ
fnp-2911	192	10	”	"	PUNCT
fnp-2911	192	11	gene	gene	NOUN
fnp-2911	192	12	,	,	PUNCT
fnp-2911	192	13	which	which	PRON
fnp-2911	192	14	provides	provide	VERB
fnp-2911	192	15	evidence	evidence	NOUN
fnp-2911	192	16	that	that	PRON
fnp-2911	192	17	altered	alter	VERB
fnp-2911	192	18	expression	expression	NOUN
fnp-2911	192	19	of	of	ADP
fnp-2911	192	20	this	this	DET
fnp-2911	192	21	gene	gene	NOUN
fnp-2911	192	22	is	be	AUX
fnp-2911	192	23	associated	associate	VERB
fnp-2911	192	24	with	with	ADP
fnp-2911	192	25	a	a	DET
fnp-2911	192	26	gain	gain	NOUN
fnp-2911	192	27	of	of	ADP
fnp-2911	192	28	toxic	toxic	ADJ
fnp-2911	192	29	function	function	NOUN
fnp-2911	192	30	.	.	PUNCT
fnp-2911	193	1	fig	fig	NOUN
fnp-2911	193	2	4	4	NUM
fnp-2911	193	3	:	:	PUNCT
fnp-2911	194	1	c9orf72	c9orf72	ADJ
fnp-2911	194	2	transcriptome	transcriptome	PROPN
fnp-2911	194	3	reflects	reflect	VERB
fnp-2911	194	4	the	the	DET
fnp-2911	194	5	loss	loss	NOUN
fnp-2911	194	6	of	of	ADP
fnp-2911	194	7	c9orf72	c9orf72	PROPN
fnp-2911	194	8	function	function	NOUN
fnp-2911	194	9	.	.	PUNCT
fnp-2911	195	1	(	(	PUNCT
fnp-2911	195	2	a	a	X
fnp-2911	195	3	)	)	PUNCT
fnp-2911	195	4	theoretical	theoretical	ADJ
fnp-2911	195	5	analysis	analysis	NOUN
fnp-2911	195	6	within	within	ADP
fnp-2911	195	7	c9orf72	c9orf72	ADJ
fnp-2911	195	8	mutation	mutation	NOUN
fnp-2911	195	9	carriers	carrier	NOUN
fnp-2911	195	10	,	,	PUNCT
fnp-2911	195	11	we	we	PRON
fnp-2911	195	12	predict	predict	VERB
fnp-2911	195	13	that	that	SCONJ
fnp-2911	195	14	c9orf72	c9orf72	PROPN
fnp-2911	195	15	promoter	promoter	NOUN
fnp-2911	195	16	methylation	methylation	NOUN
fnp-2911	195	17	would	would	AUX
fnp-2911	195	18	negatively	negatively	ADV
fnp-2911	195	19	correlate	correlate	VERB
fnp-2911	195	20	with	with	ADP
fnp-2911	195	21	c9orf72	c9orf72	ADJ
fnp-2911	195	22	expression	expression	NOUN
fnp-2911	195	23	.	.	PUNCT
fnp-2911	196	1	(	(	PUNCT
fnp-2911	196	2	b	b	X
fnp-2911	196	3	)	)	PUNCT
fnp-2911	196	4	theoretical	theoretical	ADJ
fnp-2911	196	5	analysis	analysis	NOUN
fnp-2911	196	6	between	between	ADP
fnp-2911	196	7	c9orf72	c9orf72	ADJ
fnp-2911	196	8	mutation	mutation	NOUN
fnp-2911	196	9	carriers	carrier	NOUN
fnp-2911	196	10	and	and	CCONJ
fnp-2911	196	11	non	non	ADJ
fnp-2911	196	12	-	-	ADJ
fnp-2911	196	13	diseased	diseased	ADJ
fnp-2911	196	14	controls	control	NOUN
fnp-2911	196	15	,	,	PUNCT
fnp-2911	196	16	we	we	PRON
fnp-2911	196	17	predict	predict	VERB
fnp-2911	196	18	that	that	SCONJ
fnp-2911	196	19	c9orf72	c9orf72	ADJ
fnp-2911	196	20	expression	expression	NOUN
fnp-2911	196	21	is	be	AUX
fnp-2911	196	22	downregulated	downregulate	VERB
fnp-2911	196	23	compared	compare	VERB
fnp-2911	196	24	to	to	ADP
fnp-2911	196	25	controls	control	NOUN
fnp-2911	196	26	.	.	PUNCT
fnp-2911	197	1	this	this	PRON
fnp-2911	197	2	would	would	AUX
fnp-2911	197	3	be	be	AUX
fnp-2911	197	4	an	an	DET
fnp-2911	197	5	example	example	NOUN
fnp-2911	197	6	of	of	ADP
fnp-2911	197	7	a	a	DET
fnp-2911	197	8	“	"	PUNCT
fnp-2911	197	9	concordant	concordant	ADJ
fnp-2911	197	10	”	"	PUNCT
fnp-2911	197	11	gene	gene	NOUN
fnp-2911	197	12	that	that	PRON
fnp-2911	197	13	suggests	suggest	VERB
fnp-2911	197	14	this	this	DET
fnp-2911	197	15	gene	gene	NOUN
fnp-2911	197	16	is	be	AUX
fnp-2911	197	17	linked	link	VERB
fnp-2911	197	18	to	to	ADP
fnp-2911	197	19	loss	loss	NOUN
fnp-2911	197	20	of	of	ADP
fnp-2911	197	21	c9orf72	c9orf72	ADJ
fnp-2911	197	22	protein	protein	NOUN
fnp-2911	197	23	.	.	PUNCT
fnp-2911	198	1	(	(	PUNCT
fnp-2911	198	2	c	c	X
fnp-2911	198	3	)	)	PUNCT
fnp-2911	198	4	theoretical	theoretical	ADJ
fnp-2911	198	5	analysis	analysis	NOUN
fnp-2911	198	6	within	within	ADP
fnp-2911	198	7	c9orf72	c9orf72	ADJ
fnp-2911	198	8	mutation	mutation	NOUN
fnp-2911	198	9	carriers	carrier	NOUN
fnp-2911	198	10	,	,	PUNCT
fnp-2911	198	11	we	we	PRON
fnp-2911	198	12	predict	predict	VERB
fnp-2911	198	13	that	that	SCONJ
fnp-2911	198	14	c9orf72	c9orf72	PROPN
fnp-2911	198	15	promoter	promoter	NOUN
fnp-2911	198	16	methylation	methylation	NOUN
fnp-2911	198	17	would	would	AUX
fnp-2911	198	18	negative	negative	ADV
fnp-2911	198	19	correlate	correlate	VERB
fnp-2911	198	20	with	with	ADP
fnp-2911	198	21	toxic	toxic	ADJ
fnp-2911	198	22	rna	rna	NOUN
fnp-2911	198	23	.	.	PUNCT
fnp-2911	199	1	(	(	PUNCT
fnp-2911	199	2	d	d	X
fnp-2911	199	3	)	)	PUNCT
fnp-2911	199	4	theoretical	theoretical	ADJ
fnp-2911	199	5	analysis	analysis	NOUN
fnp-2911	199	6	between	between	ADP
fnp-2911	199	7	c9orf72	c9orf72	ADJ
fnp-2911	199	8	expansion	expansion	NOUN
fnp-2911	199	9	carriers	carrier	NOUN
fnp-2911	199	10	and	and	CCONJ
fnp-2911	199	11	non	non	ADJ
fnp-2911	199	12	-	-	ADJ
fnp-2911	199	13	diseased	diseased	ADJ
fnp-2911	199	14	controls	control	NOUN
fnp-2911	199	15	,	,	PUNCT
fnp-2911	199	16	we	we	PRON
fnp-2911	199	17	predict	predict	VERB
fnp-2911	199	18	that	that	DET
fnp-2911	199	19	toxic	toxic	ADJ
fnp-2911	199	20	rna	rna	NOUN
fnp-2911	199	21	expression	expression	NOUN
fnp-2911	199	22	would	would	AUX
fnp-2911	199	23	be	be	AUX
fnp-2911	199	24	upregulated	upregulate	VERB
fnp-2911	199	25	.	.	PUNCT
fnp-2911	200	1	this	this	PRON
fnp-2911	200	2	would	would	AUX
fnp-2911	200	3	be	be	AUX
fnp-2911	200	4	an	an	DET
fnp-2911	200	5	example	example	NOUN
fnp-2911	200	6	of	of	ADP
fnp-2911	200	7	a	a	DET
fnp-2911	200	8	“	"	PUNCT
fnp-2911	200	9	discordant	discordant	ADJ
fnp-2911	200	10	”	"	PUNCT
fnp-2911	200	11	gene	gene	NOUN
fnp-2911	200	12	that	that	PRON
fnp-2911	200	13	suggests	suggest	VERB
fnp-2911	200	14	this	this	DET
fnp-2911	200	15	gene	gene	NOUN
fnp-2911	200	16	is	be	AUX
fnp-2911	200	17	linked	link	VERB
fnp-2911	200	18	to	to	ADP
fnp-2911	200	19	gain	gain	VERB
fnp-2911	200	20	of	of	ADP
fnp-2911	200	21	toxic	toxic	ADJ
fnp-2911	200	22	rna	rna	NOUN
fnp-2911	200	23	.	.	PUNCT
fnp-2911	201	1	(	(	PUNCT
fnp-2911	201	2	e	e	X
fnp-2911	201	3	)	)	PUNCT
fnp-2911	201	4	within	within	ADP
fnp-2911	201	5	the	the	DET
fnp-2911	201	6	actual	actual	ADJ
fnp-2911	201	7	data	datum	NOUN
fnp-2911	201	8	,	,	PUNCT
fnp-2911	201	9	there	there	PRON
fnp-2911	201	10	was	be	VERB
fnp-2911	201	11	a	a	DET
fnp-2911	201	12	negative	negative	ADJ
fnp-2911	201	13	relationship	relationship	NOUN
fnp-2911	201	14	between	between	ADP
fnp-2911	201	15	c9orf72	c9orf72	ADJ
fnp-2911	201	16	expression	expression	NOUN
fnp-2911	201	17	and	and	CCONJ
fnp-2911	201	18	methylation	methylation	NOUN
fnp-2911	201	19	(	(	PUNCT
fnp-2911	201	20	pearson	pearson	PROPN
fnp-2911	201	21	r=-0.6958	r=-0.6958	PROPN
fnp-2911	201	22	,	,	PUNCT
fnp-2911	201	23	p=0.0825	p=0.0825	PROPN
fnp-2911	201	24	)	)	PUNCT
fnp-2911	201	25	.	.	PUNCT
fnp-2911	202	1	(	(	PUNCT
fnp-2911	202	2	f	f	X
fnp-2911	202	3	)	)	PUNCT
fnp-2911	202	4	c9orf72	c9orf72	ADJ
fnp-2911	202	5	expression	expression	NOUN
fnp-2911	202	6	is	be	AUX
fnp-2911	202	7	downregulated	downregulate	VERB
fnp-2911	202	8	in	in	ADP
fnp-2911	202	9	c9orf72	c9orf72	ADJ
fnp-2911	202	10	expansion	expansion	NOUN
fnp-2911	202	11	carriers	carrier	NOUN
fnp-2911	202	12	compared	compare	VERB
fnp-2911	202	13	to	to	ADP
fnp-2911	202	14	controls	control	NOUN
fnp-2911	202	15	(	(	PUNCT
fnp-2911	202	16	t	t	NOUN
fnp-2911	202	17	-	-	PUNCT
fnp-2911	202	18	test	test	NOUN
fnp-2911	202	19	,	,	PUNCT
fnp-2911	202	20	p=0.0003	p=0.0003	NOUN
fnp-2911	202	21	)	)	PUNCT
fnp-2911	202	22	as	as	SCONJ
fnp-2911	202	23	predicted	predict	VERB
fnp-2911	202	24	in	in	ADP
fnp-2911	202	25	genes	gene	NOUN
fnp-2911	202	26	associated	associate	VERB
fnp-2911	202	27	with	with	ADP
fnp-2911	202	28	the	the	DET
fnp-2911	202	29	loss	loss	NOUN
fnp-2911	202	30	of	of	ADP
fnp-2911	202	31	c9orf72	c9orf72	ADJ
fnp-2911	202	32	protein	protein	NOUN
fnp-2911	202	33	.	.	PUNCT
fnp-2911	203	1	(	(	PUNCT
fnp-2911	203	2	g	g	NOUN
fnp-2911	203	3	)	)	PUNCT
fnp-2911	203	4	within	within	ADP
fnp-2911	203	5	c9orf72	c9orf72	ADJ
fnp-2911	203	6	mutation	mutation	NOUN
fnp-2911	203	7	carriers	carrier	NOUN
fnp-2911	203	8	,	,	PUNCT
fnp-2911	203	9	there	there	PRON
fnp-2911	203	10	was	be	VERB
fnp-2911	203	11	a	a	DET
fnp-2911	203	12	strong	strong	ADJ
fnp-2911	203	13	correlation	correlation	NOUN
fnp-2911	203	14	between	between	ADP
fnp-2911	203	15	the	the	DET
fnp-2911	203	16	expression	expression	NOUN
fnp-2911	203	17	of	of	ADP
fnp-2911	203	18	syp	syp	PROPN
fnp-2911	203	19	and	and	CCONJ
fnp-2911	203	20	c9orf72	c9orf72	PROPN
fnp-2911	203	21	methylation	methylation	NOUN
fnp-2911	203	22	(	(	PUNCT
fnp-2911	203	23	pearson	pearson	PROPN
fnp-2911	203	24	r=0.8835	r=0.8835	PROPN
fnp-2911	203	25	,	,	PUNCT
fnp-2911	203	26	p=0.0083	p=0.0083	PROPN
fnp-2911	203	27	)	)	PUNCT
fnp-2911	203	28	.	.	PUNCT
fnp-2911	204	1	(	(	PUNCT
fnp-2911	204	2	h	h	NOUN
fnp-2911	204	3	)	)	PUNCT
fnp-2911	204	4	between	between	ADP
fnp-2911	204	5	c9orf72	c9orf72	ADJ
fnp-2911	204	6	expansion	expansion	NOUN
fnp-2911	204	7	carriers	carrier	NOUN
fnp-2911	204	8	and	and	CCONJ
fnp-2911	204	9	controls	control	NOUN
fnp-2911	204	10	,	,	PUNCT
fnp-2911	204	11	there	there	PRON
fnp-2911	204	12	was	be	VERB
fnp-2911	204	13	a	a	DET
fnp-2911	204	14	significant	significant	ADJ
fnp-2911	204	15	upregulation	upregulation	NOUN
fnp-2911	204	16	of	of	ADP
fnp-2911	204	17	syp	syp	PROPN
fnp-2911	204	18	in	in	ADP
fnp-2911	204	19	expansion	expansion	NOUN
fnp-2911	204	20	carriers	carrier	NOUN
fnp-2911	204	21	(	(	PUNCT
fnp-2911	204	22	t	t	NOUN
fnp-2911	204	23	-	-	PUNCT
fnp-2911	204	24	test	test	NOUN
fnp-2911	204	25	,	,	PUNCT
fnp-2911	204	26	p=0.03	p=0.03	ADJ
fnp-2911	204	27	)	)	PUNCT
fnp-2911	204	28	.	.	PUNCT
fnp-2911	205	1	(	(	PUNCT
fnp-2911	205	2	i	i	NOUN
fnp-2911	205	3	)	)	PUNCT
fnp-2911	205	4	using	use	VERB
fnp-2911	205	5	significantly	significantly	ADV
fnp-2911	205	6	differentially	differentially	ADV
fnp-2911	205	7	expressed	express	VERB
fnp-2911	205	8	genes	gene	NOUN
fnp-2911	205	9	,	,	PUNCT
fnp-2911	205	10	the	the	DET
fnp-2911	205	11	methylation	methylation	NOUN
fnp-2911	205	12	correlation	correlation	NOUN
fnp-2911	205	13	within	within	ADP
fnp-2911	205	14	c9orf72	c9orf72	ADJ
fnp-2911	205	15	mutation	mutation	NOUN
fnp-2911	205	16	cases	case	NOUN
fnp-2911	205	17	was	be	AUX
fnp-2911	205	18	plotted	plot	VERB
fnp-2911	205	19	against	against	ADP
fnp-2911	205	20	gene	gene	NOUN
fnp-2911	205	21	fold	fold	NOUN
fnp-2911	205	22	change	change	NOUN
fnp-2911	205	23	between	between	ADP
fnp-2911	205	24	normal	normal	ADJ
fnp-2911	205	25	c9orf72	c9orf72	PROPN
fnp-2911	205	26	mutation	mutation	NOUN
fnp-2911	205	27	cases	case	NOUN
fnp-2911	205	28	and	and	CCONJ
fnp-2911	205	29	controls	control	NOUN
fnp-2911	205	30	.	.	PUNCT
fnp-2911	206	1	there	there	PRON
fnp-2911	206	2	were	be	VERB
fnp-2911	206	3	more	more	ADV
fnp-2911	206	4	concordant	concordant	ADJ
fnp-2911	206	5	genes	gene	NOUN
fnp-2911	206	6	than	than	ADP
fnp-2911	206	7	discordant	discordant	ADJ
fnp-2911	206	8	genes	gene	NOUN
fnp-2911	206	9	,	,	PUNCT
fnp-2911	206	10	reflecting	reflect	VERB
fnp-2911	206	11	that	that	SCONJ
fnp-2911	206	12	the	the	DET
fnp-2911	206	13	transcriptome	transcriptome	NOUN
fnp-2911	206	14	was	be	AUX
fnp-2911	206	15	associated	associate	VERB
fnp-2911	206	16	with	with	ADP
fnp-2911	206	17	loss	loss	NOUN
fnp-2911	206	18	of	of	ADP
fnp-2911	206	19	c9orf72	c9orf72	ADJ
fnp-2911	206	20	protein	protein	NOUN
fnp-2911	206	21	.	.	PUNCT
fnp-2911	207	1	(	(	PUNCT
fnp-2911	207	2	h	h	NOUN
fnp-2911	207	3	)	)	PUNCT
fnp-2911	207	4	genome	genome	NOUN
fnp-2911	207	5	wide	wide	ADJ
fnp-2911	207	6	analysis	analysis	NOUN
fnp-2911	207	7	of	of	ADP
fnp-2911	207	8	methylation	methylation	NOUN
fnp-2911	207	9	correlation	correlation	NOUN
fnp-2911	207	10	vs	vs	ADP
fnp-2911	207	11	gene	gene	NOUN
fnp-2911	207	12	fold	fold	NOUN
fnp-2911	207	13	change	change	NOUN
fnp-2911	207	14	shows	show	VERB
fnp-2911	207	15	the	the	DET
fnp-2911	207	16	same	same	ADJ
fnp-2911	207	17	trend	trend	NOUN
fnp-2911	207	18	.	.	PUNCT
fnp-2911	208	1	using	use	VERB
fnp-2911	208	2	the	the	DET
fnp-2911	208	3	actual	actual	ADJ
fnp-2911	208	4	data	datum	NOUN
fnp-2911	208	5	,	,	PUNCT
fnp-2911	208	6	a	a	DET
fnp-2911	208	7	correlation	correlation	NOUN
fnp-2911	208	8	analysis	analysis	NOUN
fnp-2911	208	9	was	be	AUX
fnp-2911	208	10	performed	perform	VERB
fnp-2911	208	11	comparing	compare	VERB
fnp-2911	208	12	c9orf72	c9orf72	ADJ
fnp-2911	208	13	expression	expression	NOUN
fnp-2911	208	14	and	and	CCONJ
fnp-2911	208	15	methylation	methylation	NOUN
fnp-2911	208	16	of	of	ADP
fnp-2911	208	17	the	the	DET
fnp-2911	208	18	c9orf72	c9orf72	PROPN
fnp-2911	208	19	promoter	promoter	NOUN
fnp-2911	208	20	within	within	ADP
fnp-2911	208	21	our	our	PRON
fnp-2911	208	22	c9orf72	c9orf72	ADJ
fnp-2911	208	23	expansion	expansion	NOUN
fnp-2911	208	24	cohort	cohort	NOUN
fnp-2911	208	25	(	(	PUNCT
fnp-2911	208	26	pearson	pearson	PROPN
fnp-2911	208	27	’s	’s	PART
fnp-2911	208	28	r=-0.6958	r=-0.6958	NOUN
fnp-2911	208	29	;	;	PUNCT
fnp-2911	208	30	p=0.0825	p=0.0825	PROPN
fnp-2911	208	31	)	)	PUNCT
fnp-2911	208	32	(	(	PUNCT
fnp-2911	208	33	fig	fig	NOUN
fnp-2911	208	34	4e	4e	NOUN
fnp-2911	208	35	)	)	PUNCT
fnp-2911	208	36	.	.	PUNCT
fnp-2911	209	1	moreover	moreover	ADV
fnp-2911	209	2	,	,	PUNCT
fnp-2911	209	3	between	between	ADP
fnp-2911	209	4	-	-	PUNCT
fnp-2911	209	5	group	group	NOUN
fnp-2911	209	6	analysis	analysis	NOUN
fnp-2911	209	7	revealed	reveal	VERB
fnp-2911	209	8	that	that	SCONJ
fnp-2911	209	9	c9orf72	c9orf72	ADJ
fnp-2911	209	10	expression	expression	NOUN
fnp-2911	209	11	is	be	AUX
fnp-2911	209	12	downregulated	downregulate	VERB
fnp-2911	209	13	in	in	ADP
fnp-2911	209	14	c9orf72	c9orf72	ADJ
fnp-2911	209	15	expansion	expansion	NOUN
fnp-2911	209	16	carriers	carrier	NOUN
fnp-2911	209	17	compared	compare	VERB
fnp-2911	209	18	to	to	ADP
fnp-2911	209	19	controls	control	NOUN
fnp-2911	209	20	as	as	SCONJ
fnp-2911	209	21	expected	expect	VERB
fnp-2911	209	22	(	(	PUNCT
fnp-2911	209	23	t	t	NOUN
fnp-2911	209	24	-	-	PUNCT
fnp-2911	209	25	test	test	NOUN
fnp-2911	209	26	,	,	PUNCT
fnp-2911	209	27	p=0.0003	p=0.0003	NOUN
fnp-2911	209	28	)	)	PUNCT
fnp-2911	209	29	(	(	PUNCT
fnp-2911	209	30	fig	fig	NOUN
fnp-2911	209	31	4f	4f	NUM
fnp-2911	209	32	)	)	PUNCT
fnp-2911	209	33	.	.	PUNCT
fnp-2911	210	1	another	another	DET
fnp-2911	210	2	example	example	NOUN
fnp-2911	210	3	of	of	ADP
fnp-2911	210	4	a	a	DET
fnp-2911	210	5	“	"	PUNCT
fnp-2911	210	6	concordant	concordant	ADJ
fnp-2911	210	7	”	"	PUNCT
fnp-2911	210	8	gene	gene	NOUN
fnp-2911	210	9	is	be	AUX
fnp-2911	210	10	synaptophysin	synaptophysin	NOUN
fnp-2911	210	11	(	(	PUNCT
fnp-2911	210	12	syp	syp	PROPN
fnp-2911	210	13	)	)	PUNCT
fnp-2911	210	14	,	,	PUNCT
fnp-2911	210	15	a	a	DET
fnp-2911	210	16	synaptic	synaptic	ADJ
fnp-2911	210	17	vesicle	vesicle	NOUN
fnp-2911	210	18	protein	protein	NOUN
fnp-2911	210	19	.	.	PUNCT
fnp-2911	211	1	the	the	DET
fnp-2911	211	2	same	same	ADJ
fnp-2911	211	3	correlation	correlation	NOUN
fnp-2911	211	4	analysis	analysis	NOUN
fnp-2911	211	5	was	be	AUX
fnp-2911	211	6	done	do	VERB
fnp-2911	211	7	which	which	PRON
fnp-2911	211	8	showed	show	VERB
fnp-2911	211	9	a	a	DET
fnp-2911	211	10	positive	positive	ADJ
fnp-2911	211	11	correlation	correlation	NOUN
fnp-2911	211	12	within	within	ADP
fnp-2911	211	13	c9orf72	c9orf72	ADJ
fnp-2911	211	14	expansion	expansion	NOUN
fnp-2911	211	15	carriers	carrier	NOUN
fnp-2911	211	16	(	(	PUNCT
fnp-2911	211	17	pearson	pearson	PROPN
fnp-2911	211	18	’s	’s	PART
fnp-2911	211	19	r=0.8835	r=0.8835	NOUN
fnp-2911	211	20	;	;	PUNCT
fnp-2911	211	21	p=0.0083	p=0.0083	PROPN
fnp-2911	211	22	)	)	PUNCT
fnp-2911	211	23	,	,	PUNCT
fnp-2911	211	24	and	and	CCONJ
fnp-2911	211	25	an	an	DET
fnp-2911	211	26	increase	increase	NOUN
fnp-2911	211	27	in	in	ADP
fnp-2911	211	28	expression	expression	NOUN
fnp-2911	211	29	in	in	ADP
fnp-2911	211	30	c9orf72	c9orf72	ADJ
fnp-2911	211	31	expansion	expansion	NOUN
fnp-2911	211	32	carriers	carrier	NOUN
fnp-2911	211	33	compared	compare	VERB
fnp-2911	211	34	to	to	ADP
fnp-2911	211	35	controls	control	NOUN
fnp-2911	211	36	(	(	PUNCT
fnp-2911	211	37	t	t	NOUN
fnp-2911	211	38	-	-	PUNCT
fnp-2911	211	39	test	test	NOUN
fnp-2911	211	40	,	,	PUNCT
fnp-2911	211	41	p=0.03	p=0.03	ADJ
fnp-2911	211	42	)	)	PUNCT
fnp-2911	211	43	(	(	PUNCT
fnp-2911	211	44	fig	fig	NOUN
fnp-2911	211	45	4g	4g	NOUN
fnp-2911	211	46	-	-	PUNCT
fnp-2911	211	47	h	h	NOUN
fnp-2911	211	48	,	,	PUNCT
fnp-2911	211	49	supplemental	supplemental	ADJ
fnp-2911	211	50	table	table	NOUN
fnp-2911	211	51	4	4	NUM
fnp-2911	211	52	)	)	PUNCT
fnp-2911	211	53	.	.	PUNCT
fnp-2911	212	1	thus	thus	ADV
fnp-2911	212	2	,	,	PUNCT
fnp-2911	212	3	we	we	PRON
fnp-2911	212	4	are	be	AUX
fnp-2911	212	5	able	able	ADJ
fnp-2911	212	6	to	to	PART
fnp-2911	212	7	show	show	VERB
fnp-2911	212	8	that	that	SCONJ
fnp-2911	212	9	“	"	PUNCT
fnp-2911	212	10	concordant	concordant	ADJ
fnp-2911	212	11	”	"	PUNCT
fnp-2911	212	12	genes	gene	NOUN
fnp-2911	212	13	tend	tend	VERB
fnp-2911	212	14	to	to	PART
fnp-2911	212	15	reflect	reflect	VERB
fnp-2911	212	16	genes	gene	NOUN
fnp-2911	212	17	that	that	PRON
fnp-2911	212	18	may	may	AUX
fnp-2911	212	19	be	be	AUX
fnp-2911	212	20	related	relate	VERB
fnp-2911	212	21	to	to	ADP
fnp-2911	212	22	c9orf72	c9orf72	ADJ
fnp-2911	212	23	protein	protein	NOUN
fnp-2911	212	24	function	function	NOUN
fnp-2911	212	25	.	.	PUNCT
fnp-2911	213	1	this	this	DET
fnp-2911	213	2	analysis	analysis	NOUN
fnp-2911	213	3	was	be	AUX
fnp-2911	213	4	extended	extend	VERB
fnp-2911	213	5	to	to	ADP
fnp-2911	213	6	all	all	PRON
fnp-2911	213	7	significantly	significantly	ADV
fnp-2911	213	8	differentially	differentially	ADV
fnp-2911	213	9	expressed	express	VERB
fnp-2911	213	10	genes	gene	NOUN
fnp-2911	213	11	where	where	SCONJ
fnp-2911	213	12	the	the	DET
fnp-2911	213	13	“	"	PUNCT
fnp-2911	213	14	within	within	ADP
fnp-2911	213	15	c9orf72	c9orf72	ADJ
fnp-2911	213	16	mutation	mutation	NOUN
fnp-2911	213	17	cases	case	NOUN
fnp-2911	213	18	”	"	PUNCT
fnp-2911	213	19	methylation	methylation	NOUN
fnp-2911	213	20	correlation	correlation	NOUN
fnp-2911	213	21	value	value	NOUN
fnp-2911	213	22	was	be	AUX
fnp-2911	213	23	plotted	plot	VERB
fnp-2911	213	24	as	as	ADP
fnp-2911	213	25	a	a	DET
fnp-2911	213	26	function	function	NOUN
fnp-2911	213	27	of	of	ADP
fnp-2911	213	28	“	"	PUNCT
fnp-2911	213	29	between	between	ADP
fnp-2911	213	30	c9orf72	c9orf72	ADJ
fnp-2911	213	31	cases	case	NOUN
fnp-2911	213	32	and	and	CCONJ
fnp-2911	213	33	controls	control	NOUN
fnp-2911	213	34	”	"	PUNCT
fnp-2911	213	35	gene	gene	NOUN
fnp-2911	213	36	fold	fold	NOUN
fnp-2911	213	37	change	change	NOUN
fnp-2911	213	38	values	value	NOUN
fnp-2911	213	39	(	(	PUNCT
fnp-2911	213	40	fig	fig	NOUN
fnp-2911	213	41	4i	4i	NUM
fnp-2911	213	42	)	)	PUNCT
fnp-2911	213	43	.	.	PUNCT
fnp-2911	214	1	across	across	ADP
fnp-2911	214	2	all	all	PRON
fnp-2911	214	3	significantly	significantly	ADV
fnp-2911	214	4	differentially	differentially	ADV
fnp-2911	214	5	expressed	express	VERB
fnp-2911	214	6	genes	gene	NOUN
fnp-2911	214	7	,	,	PUNCT
fnp-2911	214	8	there	there	PRON
fnp-2911	214	9	were	be	VERB
fnp-2911	214	10	267	267	NUM
fnp-2911	214	11	genes	gene	NOUN
fnp-2911	214	12	found	find	VERB
fnp-2911	214	13	within	within	ADP
fnp-2911	214	14	the	the	DET
fnp-2911	214	15	concordant	concordant	ADJ
fnp-2911	214	16	quadrants	quadrant	NOUN
fnp-2911	214	17	(	(	PUNCT
fnp-2911	214	18	blue	blue	ADJ
fnp-2911	214	19	circles	circle	NOUN
fnp-2911	214	20	)	)	PUNCT
fnp-2911	214	21	compared	compare	VERB
fnp-2911	214	22	to	to	ADP
fnp-2911	214	23	only	only	ADV
fnp-2911	214	24	56	56	NUM
fnp-2911	214	25	genes	gene	NOUN
fnp-2911	214	26	found	find	VERB
fnp-2911	214	27	in	in	ADP
fnp-2911	214	28	the	the	DET
fnp-2911	214	29	discordant	discordant	ADJ
fnp-2911	214	30	quadrants	quadrant	NOUN
fnp-2911	214	31	(	(	PUNCT
fnp-2911	214	32	red	red	ADJ
fnp-2911	214	33	circles	circle	NOUN
fnp-2911	214	34	)	)	PUNCT
fnp-2911	214	35	(	(	PUNCT
fnp-2911	214	36	fig	fig	NOUN
fnp-2911	214	37	4	4	NUM
fnp-2911	214	38	g	g	NOUN
fnp-2911	214	39	)	)	PUNCT
fnp-2911	214	40	.	.	PUNCT
fnp-2911	215	1	similar	similar	ADJ
fnp-2911	215	2	results	result	NOUN
fnp-2911	215	3	were	be	AUX
fnp-2911	215	4	found	find	VERB
fnp-2911	215	5	when	when	SCONJ
fnp-2911	215	6	this	this	DET
fnp-2911	215	7	analysis	analysis	NOUN
fnp-2911	215	8	was	be	AUX
fnp-2911	215	9	further	far	ADV
fnp-2911	215	10	expanded	expand	VERB
fnp-2911	215	11	transcriptome	transcriptome	NOUN
fnp-2911	215	12	-	-	PUNCT
fnp-2911	215	13	wide	wide	ADV
fnp-2911	215	14	,	,	PUNCT
fnp-2911	215	15	suggesting	suggest	VERB
fnp-2911	215	16	that	that	SCONJ
fnp-2911	215	17	the	the	DET
fnp-2911	215	18	global	global	ADJ
fnp-2911	215	19	transcriptome	transcriptome	ADJ
fnp-2911	215	20	changes	change	NOUN
fnp-2911	215	21	linked	link	VERB
fnp-2911	215	22	to	to	ADP
fnp-2911	215	23	the	the	DET
fnp-2911	215	24	c9orf72	c9orf72	PROPN
fnp-2911	215	25	mutation	mutation	NOUN
fnp-2911	215	26	are	be	AUX
fnp-2911	215	27	associated	associate	VERB
fnp-2911	215	28	with	with	ADP
fnp-2911	215	29	loss	loss	NOUN
fnp-2911	215	30	of	of	ADP
fnp-2911	215	31	c9orf72	c9orf72	ADJ
fnp-2911	215	32	protein	protein	NOUN
fnp-2911	215	33	(	(	PUNCT
fnp-2911	215	34	fig	fig	NOUN
fnp-2911	215	35	4h	4h	NOUN
fnp-2911	215	36	)	)	PUNCT
fnp-2911	215	37	.	.	PUNCT
fnp-2911	216	1	many	many	ADJ
fnp-2911	216	2	“	"	PUNCT
fnp-2911	216	3	concordant	concordant	ADJ
fnp-2911	216	4	”	"	PUNCT
fnp-2911	216	5	genes	gene	NOUN
fnp-2911	216	6	were	be	AUX
fnp-2911	216	7	genes	gene	NOUN
fnp-2911	216	8	involved	involve	VERB
fnp-2911	216	9	in	in	ADP
fnp-2911	216	10	synaptic	synaptic	ADJ
fnp-2911	216	11	vesicle	vesicle	NOUN
fnp-2911	216	12	formation	formation	NOUN
fnp-2911	216	13	(	(	PUNCT
fnp-2911	216	14	i.e.	i.e.	X
fnp-2911	216	15	clathrin	clathrin	NOUN
fnp-2911	216	16	light	light	ADJ
fnp-2911	216	17	chain	chain	NOUN
fnp-2911	216	18	b	b	NOUN
fnp-2911	216	19	,	,	PUNCT
fnp-2911	216	20	syntaphilin	syntaphilin	NOUN
fnp-2911	216	21	,	,	PUNCT
fnp-2911	216	22	synaptophysin	synaptophysin	NOUN
fnp-2911	216	23	)	)	PUNCT
fnp-2911	216	24	and	and	CCONJ
fnp-2911	216	25	vesicle	vesicle	NOUN
fnp-2911	216	26	trafficking	trafficking	NOUN
fnp-2911	216	27	(	(	PUNCT
fnp-2911	216	28	i.e.	i.e.	X
fnp-2911	216	29	multivesicular	multivesicular	ADJ
fnp-2911	216	30	body	body	NOUN
fnp-2911	216	31	subunit	subunit	NOUN
fnp-2911	216	32	12a	12a	NOUN
fnp-2911	216	33	,	,	PUNCT
fnp-2911	216	34	rab40b	rab40b	NUM
fnp-2911	216	35	,	,	PUNCT
fnp-2911	216	36	member	member	NOUN
fnp-2911	216	37	ras	ras	PROPN
fnp-2911	216	38	oncogene	oncogene	NOUN
fnp-2911	216	39	family	family	NOUN
fnp-2911	216	40	)	)	PUNCT
fnp-2911	216	41	.	.	PUNCT
fnp-2911	217	1	genes	gene	NOUN
fnp-2911	217	2	labeled	label	VERB
fnp-2911	217	3	as	as	ADP
fnp-2911	217	4	“	"	PUNCT
fnp-2911	217	5	discordant	discordant	ADJ
fnp-2911	217	6	”	"	PUNCT
fnp-2911	217	7	include	include	VERB
fnp-2911	217	8	genes	gene	NOUN
fnp-2911	217	9	related	relate	VERB
fnp-2911	217	10	to	to	ADP
fnp-2911	217	11	inflammatory	inflammatory	ADJ
fnp-2911	217	12	or	or	CCONJ
fnp-2911	217	13	apoptotic	apoptotic	ADJ
fnp-2911	217	14	processes	process	NOUN
fnp-2911	217	15	including	include	VERB
fnp-2911	217	16	tec	tec	ADJ
fnp-2911	217	17	protein	protein	NOUN
fnp-2911	217	18	tyrosine	tyrosine	NOUN
fnp-2911	217	19	kinase	kinase	PROPN
fnp-2911	217	20	,	,	PUNCT
fnp-2911	217	21	tyrosine	tyrosine	PROPN
fnp-2911	217	22	kinase	kinase	PROPN
fnp-2911	217	23	,	,	PUNCT
fnp-2911	217	24	and	and	CCONJ
fnp-2911	217	25	ring	ring	NOUN
fnp-2911	217	26	finger	finger	NOUN
fnp-2911	217	27	protein	protein	NOUN
fnp-2911	217	28	152	152	NUM
fnp-2911	217	29	.	.	PUNCT
fnp-2911	218	1	thus	thus	ADV
fnp-2911	218	2	two	two	NUM
fnp-2911	218	3	different	different	ADJ
fnp-2911	218	4	factors	factor	NOUN
fnp-2911	218	5	appear	appear	VERB
fnp-2911	218	6	to	to	PART
fnp-2911	218	7	shape	shape	VERB
fnp-2911	218	8	this	this	DET
fnp-2911	218	9	global	global	ADJ
fnp-2911	218	10	c9orf72	c9orf72	PROPN
fnp-2911	218	11	transcriptome	transcriptome	PROPN
fnp-2911	218	12	dataset	dataset	NOUN
fnp-2911	218	13	:	:	PUNCT
fnp-2911	218	14	(	(	PUNCT
fnp-2911	218	15	1	1	X
fnp-2911	218	16	)	)	PUNCT
fnp-2911	218	17	the	the	DET
fnp-2911	218	18	depletion	depletion	NOUN
fnp-2911	218	19	of	of	ADP
fnp-2911	218	20	neurons	neuron	NOUN
fnp-2911	218	21	with	with	ADP
fnp-2911	218	22	tdp-43	tdp-43	PROPN
fnp-2911	218	23	pathology	pathology	PROPN
fnp-2911	218	24	prior	prior	ADV
fnp-2911	218	25	to	to	ADP
fnp-2911	218	26	rna	rna	NOUN
fnp-2911	218	27	-	-	PUNCT
fnp-2911	218	28	sequencing	sequence	VERB
fnp-2911	218	29	and	and	CCONJ
fnp-2911	218	30	(	(	PUNCT
fnp-2911	218	31	2	2	X
fnp-2911	218	32	)	)	PUNCT
fnp-2911	218	33	the	the	DET
fnp-2911	218	34	loss	loss	NOUN
fnp-2911	218	35	of	of	ADP
fnp-2911	218	36	c9orf72	c9orf72	PROPN
fnp-2911	218	37	function	function	NOUN
fnp-2911	218	38	.	.	PUNCT
fnp-2911	219	1	to	to	PART
fnp-2911	219	2	estimate	estimate	VERB
fnp-2911	219	3	the	the	DET
fnp-2911	219	4	relative	relative	ADJ
fnp-2911	219	5	contributions	contribution	NOUN
fnp-2911	219	6	of	of	ADP
fnp-2911	219	7	these	these	DET
fnp-2911	219	8	two	two	NUM
fnp-2911	219	9	factors	factor	NOUN
fnp-2911	219	10	,	,	PUNCT
fnp-2911	219	11	a	a	DET
fnp-2911	219	12	multivariate	multivariate	NOUN
fnp-2911	219	13	linear	linear	PROPN
fnp-2911	219	14	regression	regression	NOUN
fnp-2911	219	15	analysis	analysis	NOUN
fnp-2911	219	16	was	be	AUX
fnp-2911	219	17	performed	perform	VERB
fnp-2911	219	18	wherein	wherein	ADJ
fnp-2911	219	19	significant	significant	ADJ
fnp-2911	219	20	changes	change	NOUN
fnp-2911	219	21	in	in	ADP
fnp-2911	219	22	gene	gene	NOUN
fnp-2911	219	23	expression	expression	NOUN
fnp-2911	219	24	associated	associate	VERB
fnp-2911	219	25	with	with	ADP
fnp-2911	219	26	the	the	DET
fnp-2911	219	27	c9orf72	c9orf72	PROPN
fnp-2911	219	28	mutation	mutation	NOUN
fnp-2911	219	29	were	be	AUX
fnp-2911	219	30	related	relate	VERB
fnp-2911	219	31	to	to	ADP
fnp-2911	219	32	(	(	PUNCT
fnp-2911	219	33	1	1	X
fnp-2911	219	34	)	)	PUNCT
fnp-2911	219	35	the	the	DET
fnp-2911	219	36	changes	change	NOUN
fnp-2911	219	37	in	in	ADP
fnp-2911	219	38	gene	gene	NOUN
fnp-2911	219	39	expression	expression	NOUN
fnp-2911	219	40	we	we	PRON
fnp-2911	219	41	previously	previously	ADV
fnp-2911	219	42	identified	identify	VERB
fnp-2911	219	43	due	due	ADP
fnp-2911	219	44	to	to	ADP
fnp-2911	219	45	tdp-43	tdp-43	PROPN
fnp-2911	219	46	pathology	pathology	PROPN
fnp-2911	219	47	and	and	CCONJ
fnp-2911	219	48	(	(	PUNCT
fnp-2911	219	49	2	2	X
fnp-2911	219	50	)	)	PUNCT
fnp-2911	219	51	the	the	DET
fnp-2911	219	52	loss	loss	NOUN
fnp-2911	219	53	of	of	ADP
fnp-2911	219	54	c9orf72	c9orf72	ADJ
fnp-2911	219	55	gene	gene	NOUN
fnp-2911	219	56	expression	expression	NOUN
fnp-2911	219	57	due	due	ADP
fnp-2911	219	58	to	to	ADP
fnp-2911	219	59	methylation	methylation	NOUN
fnp-2911	219	60	of	of	ADP
fnp-2911	219	61	the	the	DET
fnp-2911	219	62	c9orf72	c9orf72	PROPN
fnp-2911	219	63	promoter	promoter	NOUN
fnp-2911	219	64	.	.	PUNCT
fnp-2911	220	1	together	together	ADV
fnp-2911	220	2	,	,	PUNCT
fnp-2911	220	3	these	these	DET
fnp-2911	220	4	two	two	NUM
fnp-2911	220	5	factors	factor	NOUN
fnp-2911	220	6	explained	explain	VERB
fnp-2911	220	7	the	the	DET
fnp-2911	220	8	majority	majority	NOUN
fnp-2911	220	9	of	of	ADP
fnp-2911	220	10	the	the	DET
fnp-2911	220	11	variance	variance	NOUN
fnp-2911	220	12	in	in	ADP
fnp-2911	220	13	this	this	DET
fnp-2911	220	14	dataset	dataset	NOUN
fnp-2911	220	15	(	(	PUNCT
fnp-2911	220	16	r2=0.5138	r2=0.5138	PROPN
fnp-2911	220	17	;	;	PUNCT
fnp-2911	220	18	βmethylation=0.838	βmethylation=0.838	SYM
fnp-2911	220	19	,	,	PUNCT
fnp-2911	220	20	p<2e-16	p<2e-16	PROPN
fnp-2911	220	21	;	;	PUNCT
fnp-2911	220	22	βtdp-43=-0.499	βtdp-43=-0.499	ADJ
fnp-2911	220	23	,	,	PUNCT
fnp-2911	220	24	p<2e-16	p<2e-16	PROPN
fnp-2911	220	25	)	)	PUNCT
fnp-2911	220	26	.	.	PUNCT
fnp-2911	221	1	discussion	discussion	NOUN
fnp-2911	221	2	here	here	ADV
fnp-2911	221	3	we	we	PRON
fnp-2911	221	4	report	report	VERB
fnp-2911	221	5	that	that	SCONJ
fnp-2911	221	6	in	in	ADP
fnp-2911	221	7	using	use	VERB
fnp-2911	221	8	post	post	ADJ
fnp-2911	221	9	-	-	ADJ
fnp-2911	221	10	mortem	mortem	ADJ
fnp-2911	221	11	neuronal	neuronal	ADJ
fnp-2911	221	12	nuclei	nucleus	NOUN
fnp-2911	221	13	without	without	ADP
fnp-2911	221	14	tdp-43	tdp-43	PROPN
fnp-2911	221	15	pathology	pathology	PROPN
fnp-2911	221	16	from	from	ADP
fnp-2911	221	17	c9orf72	c9orf72	ADJ
fnp-2911	221	18	expansion	expansion	NOUN
fnp-2911	221	19	carriers	carrier	NOUN
fnp-2911	221	20	,	,	PUNCT
fnp-2911	221	21	we	we	PRON
fnp-2911	221	22	were	be	AUX
fnp-2911	221	23	able	able	ADJ
fnp-2911	221	24	to	to	PART
fnp-2911	221	25	identify	identify	VERB
fnp-2911	221	26	transcriptome	transcriptome	ADJ
fnp-2911	221	27	changes	change	NOUN
fnp-2911	221	28	that	that	PRON
fnp-2911	221	29	link	link	VERB
fnp-2911	221	30	the	the	DET
fnp-2911	221	31	c9orf72	c9orf72	PROPN
fnp-2911	221	32	mutation	mutation	NOUN
fnp-2911	221	33	with	with	ADP
fnp-2911	221	34	loss	loss	NOUN
fnp-2911	221	35	of	of	ADP
fnp-2911	221	36	c9orf72	c9orf72	PROPN
fnp-2911	221	37	function	function	NOUN
fnp-2911	221	38	.	.	PUNCT
fnp-2911	222	1	we	we	PRON
fnp-2911	222	2	found	find	VERB
fnp-2911	222	3	that	that	SCONJ
fnp-2911	222	4	the	the	DET
fnp-2911	222	5	top	top	ADJ
fnp-2911	222	6	1	1	NUM
fnp-2911	222	7	%	%	NOUN
fnp-2911	222	8	of	of	ADP
fnp-2911	222	9	genes	gene	NOUN
fnp-2911	222	10	that	that	PRON
fnp-2911	222	11	contribute	contribute	VERB
fnp-2911	222	12	most	most	ADJ
fnp-2911	222	13	to	to	ADP
fnp-2911	222	14	changes	change	NOUN
fnp-2911	222	15	in	in	ADP
fnp-2911	222	16	c9orf72	c9orf72	ADJ
fnp-2911	222	17	expression	expression	NOUN
fnp-2911	222	18	were	be	AUX
fnp-2911	222	19	involved	involve	VERB
fnp-2911	222	20	in	in	ADP
fnp-2911	222	21	cytoplasmic	cytoplasmic	ADJ
fnp-2911	222	22	vesicle	vesicle	NOUN
fnp-2911	222	23	trafficking	trafficking	NOUN
fnp-2911	222	24	.	.	PUNCT
fnp-2911	223	1	significant	significant	ADJ
fnp-2911	223	2	gene	gene	NOUN
fnp-2911	223	3	expression	expression	NOUN
fnp-2911	223	4	changes	change	NOUN
fnp-2911	223	5	were	be	AUX
fnp-2911	223	6	linked	link	VERB
fnp-2911	223	7	to	to	ADP
fnp-2911	223	8	the	the	DET
fnp-2911	223	9	c9orf72	c9orf72	PROPN
fnp-2911	223	10	mutation	mutation	NOUN
fnp-2911	223	11	and	and	CCONJ
fnp-2911	223	12	featured	feature	VERB
fnp-2911	223	13	upregulated	upregulated	ADJ
fnp-2911	223	14	genes	gene	NOUN
fnp-2911	223	15	related	relate	VERB
fnp-2911	223	16	to	to	ADP
fnp-2911	223	17	synaptic	synaptic	ADJ
fnp-2911	223	18	transmission	transmission	NOUN
fnp-2911	223	19	and	and	CCONJ
fnp-2911	223	20	endosomal	endosomal	ADJ
fnp-2911	223	21	/	/	SYM
fnp-2911	223	22	lysosomal	lysosomal	ADJ
fnp-2911	223	23	trafficking	trafficking	NOUN
fnp-2911	223	24	.	.	PUNCT
fnp-2911	224	1	indeed	indeed	ADV
fnp-2911	224	2	,	,	PUNCT
fnp-2911	224	3	c9orf72	c9orf72	PROPN
fnp-2911	224	4	has	have	AUX
fnp-2911	224	5	been	be	AUX
fnp-2911	224	6	shown	show	VERB
fnp-2911	224	7	to	to	PART
fnp-2911	224	8	be	be	AUX
fnp-2911	224	9	involved	involve	VERB
fnp-2911	224	10	in	in	ADP
fnp-2911	224	11	endosomal	endosomal	ADJ
fnp-2911	224	12	or	or	CCONJ
fnp-2911	224	13	lysosomal	lysosomal	ADJ
fnp-2911	224	14	trafficking	trafficking	NOUN
fnp-2911	224	15	and	and	CCONJ
fnp-2911	224	16	may	may	AUX
fnp-2911	224	17	be	be	AUX
fnp-2911	224	18	a	a	DET
fnp-2911	224	19	rab	rab	NOUN
fnp-2911	224	20	gtpase	gtpase	NOUN
fnp-2911	224	21	,	,	PUNCT
fnp-2911	224	22	and	and	CCONJ
fnp-2911	224	23	recent	recent	ADJ
fnp-2911	224	24	whole	whole	ADJ
fnp-2911	224	25	tissue	tissue	NOUN
fnp-2911	224	26	transcriptome	transcriptome	NOUN
fnp-2911	224	27	studies	study	NOUN
fnp-2911	224	28	have	have	AUX
fnp-2911	224	29	linked	link	VERB
fnp-2911	224	30	the	the	DET
fnp-2911	224	31	c9orf72	c9orf72	PROPN
fnp-2911	224	32	mutation	mutation	NOUN
fnp-2911	224	33	to	to	ADP
fnp-2911	224	34	changes	change	NOUN
fnp-2911	224	35	in	in	ADP
fnp-2911	224	36	vesicular	vesicular	ADJ
fnp-2911	224	37	transport	transport	NOUN
fnp-2911	224	38	genes	gene	NOUN
fnp-2911	224	39	(	(	PUNCT
fnp-2911	224	40	3	3	NUM
fnp-2911	224	41	-	-	SYM
fnp-2911	224	42	8)	8)	NUM
fnp-2911	224	43	.	.	NOUN
fnp-2911	225	1	nine	nine	NUM
fnp-2911	225	2	of	of	ADP
fnp-2911	225	3	the	the	DET
fnp-2911	225	4	11	11	NUM
fnp-2911	225	5	genes	gene	NOUN
fnp-2911	225	6	related	relate	VERB
fnp-2911	225	7	to	to	ADP
fnp-2911	225	8	trafficking	trafficking	NOUN
fnp-2911	225	9	were	be	AUX
fnp-2911	225	10	upregulated	upregulate	VERB
fnp-2911	225	11	,	,	PUNCT
fnp-2911	225	12	potentially	potentially	ADV
fnp-2911	225	13	reflecting	reflect	VERB
fnp-2911	225	14	a	a	DET
fnp-2911	225	15	compensatory	compensatory	ADJ
fnp-2911	225	16	mechanism	mechanism	NOUN
fnp-2911	225	17	to	to	PART
fnp-2911	225	18	counteract	counteract	VERB
fnp-2911	225	19	the	the	DET
fnp-2911	225	20	loss	loss	NOUN
fnp-2911	225	21	of	of	ADP
fnp-2911	225	22	c9orf72	c9orf72	NOUN
fnp-2911	225	23	and	and	CCONJ
fnp-2911	225	24	loss	loss	NOUN
fnp-2911	225	25	of	of	ADP
fnp-2911	225	26	this	this	DET
fnp-2911	225	27	trafficking	traffic	VERB
fnp-2911	225	28	related	relate	VERB
fnp-2911	225	29	protein	protein	NOUN
fnp-2911	225	30	.	.	PUNCT
fnp-2911	226	1	further	further	ADJ
fnp-2911	226	2	analysis	analysis	NOUN
fnp-2911	226	3	correlating	correlate	VERB
fnp-2911	226	4	methylation	methylation	NOUN
fnp-2911	226	5	and	and	CCONJ
fnp-2911	226	6	gene	gene	NOUN
fnp-2911	226	7	expression	expression	NOUN
fnp-2911	226	8	changes	change	NOUN
fnp-2911	226	9	confirmed	confirm	VERB
fnp-2911	226	10	that	that	SCONJ
fnp-2911	226	11	the	the	DET
fnp-2911	226	12	transcriptome	transcriptome	ADJ
fnp-2911	226	13	changes	change	NOUN
fnp-2911	226	14	are	be	AUX
fnp-2911	226	15	linked	link	VERB
fnp-2911	226	16	to	to	ADP
fnp-2911	226	17	loss	loss	NOUN
fnp-2911	226	18	of	of	ADP
fnp-2911	226	19	c9orf72	c9orf72	ADJ
fnp-2911	226	20	expression	expression	NOUN
fnp-2911	226	21	.	.	PUNCT
fnp-2911	227	1	to	to	PART
fnp-2911	227	2	parse	parse	VERB
fnp-2911	227	3	the	the	DET
fnp-2911	227	4	relative	relative	ADJ
fnp-2911	227	5	contributions	contribution	NOUN
fnp-2911	227	6	of	of	ADP
fnp-2911	227	7	c9orf72	c9orf72	ADJ
fnp-2911	227	8	protein	protein	NOUN
fnp-2911	227	9	loss	loss	NOUN
fnp-2911	227	10	or	or	CCONJ
fnp-2911	227	11	gain	gain	NOUN
fnp-2911	227	12	of	of	ADP
fnp-2911	227	13	toxic	toxic	ADJ
fnp-2911	227	14	rna	rna	PROPN
fnp-2911	227	15	,	,	PUNCT
fnp-2911	227	16	a	a	DET
fnp-2911	227	17	methylation	methylation	NOUN
fnp-2911	227	18	correlation	correlation	NOUN
fnp-2911	227	19	between	between	ADP
fnp-2911	227	20	methylation	methylation	NOUN
fnp-2911	227	21	values	value	NOUN
fnp-2911	227	22	and	and	CCONJ
fnp-2911	227	23	expression	expression	NOUN
fnp-2911	227	24	data	datum	NOUN
fnp-2911	227	25	was	be	AUX
fnp-2911	227	26	calculated	calculate	VERB
fnp-2911	227	27	.	.	PUNCT
fnp-2911	228	1	this	this	DET
fnp-2911	228	2	correlation	correlation	NOUN
fnp-2911	228	3	analysis	analysis	NOUN
fnp-2911	228	4	indicated	indicate	VERB
fnp-2911	228	5	that	that	SCONJ
fnp-2911	228	6	the	the	DET
fnp-2911	228	7	transcriptome	transcriptome	NOUN
fnp-2911	228	8	observed	observe	VERB
fnp-2911	228	9	in	in	ADP
fnp-2911	228	10	neuronal	neuronal	ADJ
fnp-2911	228	11	nuclei	nucleus	NOUN
fnp-2911	228	12	from	from	ADP
fnp-2911	228	13	c9orf72	c9orf72	ADJ
fnp-2911	228	14	expansion	expansion	NOUN
fnp-2911	228	15	cases	case	NOUN
fnp-2911	228	16	was	be	AUX
fnp-2911	228	17	driven	drive	VERB
fnp-2911	228	18	in	in	ADP
fnp-2911	228	19	large	large	ADJ
fnp-2911	228	20	part	part	NOUN
fnp-2911	228	21	by	by	ADP
fnp-2911	228	22	the	the	DET
fnp-2911	228	23	loss	loss	NOUN
fnp-2911	228	24	of	of	ADP
fnp-2911	228	25	c9orf72	c9orf72	ADJ
fnp-2911	228	26	protein	protein	NOUN
fnp-2911	228	27	as	as	SCONJ
fnp-2911	228	28	opposed	oppose	VERB
fnp-2911	228	29	to	to	ADP
fnp-2911	228	30	a	a	DET
fnp-2911	228	31	toxic	toxic	ADJ
fnp-2911	228	32	gain	gain	NOUN
fnp-2911	228	33	of	of	ADP
fnp-2911	228	34	function	function	NOUN
fnp-2911	228	35	.	.	PUNCT
fnp-2911	229	1	in	in	ADP
fnp-2911	229	2	contrast	contrast	NOUN
fnp-2911	229	3	,	,	PUNCT
fnp-2911	229	4	we	we	PRON
fnp-2911	229	5	observed	observe	VERB
fnp-2911	229	6	minor	minor	ADJ
fnp-2911	229	7	splicing	splicing	NOUN
fnp-2911	229	8	alterations	alteration	NOUN
fnp-2911	229	9	and	and	CCONJ
fnp-2911	229	10	relatively	relatively	ADV
fnp-2911	229	11	subtle	subtle	ADJ
fnp-2911	229	12	changes	change	NOUN
fnp-2911	229	13	in	in	ADP
fnp-2911	229	14	terms	term	NOUN
fnp-2911	229	15	of	of	ADP
fnp-2911	229	16	alterations	alteration	NOUN
fnp-2911	229	17	in	in	ADP
fnp-2911	229	18	rna	rna	NOUN
fnp-2911	229	19	binding	bind	VERB
fnp-2911	229	20	protein	protein	NOUN
fnp-2911	229	21	function	function	NOUN
fnp-2911	229	22	.	.	PUNCT
fnp-2911	230	1	thus	thus	ADV
fnp-2911	230	2	,	,	PUNCT
fnp-2911	230	3	the	the	DET
fnp-2911	230	4	global	global	ADJ
fnp-2911	230	5	alterations	alteration	NOUN
fnp-2911	230	6	appear	appear	VERB
fnp-2911	230	7	to	to	PART
fnp-2911	230	8	be	be	AUX
fnp-2911	230	9	most	most	ADV
fnp-2911	230	10	reflective	reflective	ADJ
fnp-2911	230	11	of	of	ADP
fnp-2911	230	12	a	a	DET
fnp-2911	230	13	loss	loss	NOUN
fnp-2911	230	14	of	of	ADP
fnp-2911	230	15	c9orf72	c9orf72	ADJ
fnp-2911	230	16	function	function	NOUN
fnp-2911	230	17	rather	rather	ADV
fnp-2911	230	18	than	than	ADP
fnp-2911	230	19	toxic	toxic	ADJ
fnp-2911	230	20	rna	rna	NOUN
fnp-2911	230	21	mediated	mediate	VERB
fnp-2911	230	22	effects	effect	NOUN
fnp-2911	230	23	.	.	PUNCT
fnp-2911	231	1	however	however	ADV
fnp-2911	231	2	,	,	PUNCT
fnp-2911	231	3	it	it	PRON
fnp-2911	231	4	should	should	AUX
fnp-2911	231	5	be	be	AUX
fnp-2911	231	6	noted	note	VERB
fnp-2911	231	7	that	that	SCONJ
fnp-2911	231	8	c9orf72	c9orf72	PROPN
fnp-2911	231	9	methylation	methylation	NOUN
fnp-2911	231	10	was	be	AUX
fnp-2911	231	11	used	use	VERB
fnp-2911	231	12	as	as	ADP
fnp-2911	231	13	a	a	DET
fnp-2911	231	14	proxy	proxy	NOUN
fnp-2911	231	15	for	for	ADP
fnp-2911	231	16	dpr	dpr	PROPN
fnp-2911	231	17	and	and	CCONJ
fnp-2911	231	18	rna	rna	PROPN
fnp-2911	231	19	foci	focus	NOUN
fnp-2911	231	20	levels	level	NOUN
fnp-2911	231	21	.	.	PUNCT
fnp-2911	232	1	a	a	DET
fnp-2911	232	2	more	more	ADV
fnp-2911	232	3	direct	direct	ADJ
fnp-2911	232	4	analysis	analysis	NOUN
fnp-2911	232	5	of	of	ADP
fnp-2911	232	6	the	the	DET
fnp-2911	232	7	effects	effect	NOUN
fnp-2911	232	8	of	of	ADP
fnp-2911	232	9	dpr	dpr	PROPN
fnp-2911	232	10	or	or	CCONJ
fnp-2911	232	11	rna	rna	PROPN
fnp-2911	232	12	foci	focus	NOUN
fnp-2911	232	13	would	would	AUX
fnp-2911	232	14	require	require	VERB
fnp-2911	232	15	specific	specific	ADJ
fnp-2911	232	16	isolation	isolation	NOUN
fnp-2911	232	17	of	of	ADP
fnp-2911	232	18	dpr	dpr	PROPN
fnp-2911	232	19	or	or	CCONJ
fnp-2911	232	20	rna	rna	NOUN
fnp-2911	232	21	-	-	PUNCT
fnp-2911	232	22	foci	focus	NOUN
fnp-2911	232	23	containing	contain	VERB
fnp-2911	232	24	neuronal	neuronal	ADJ
fnp-2911	232	25	nuclei	nucleus	NOUN
fnp-2911	232	26	which	which	PRON
fnp-2911	232	27	has	have	AUX
fnp-2911	232	28	not	not	PART
fnp-2911	232	29	yet	yet	ADV
fnp-2911	232	30	been	be	AUX
fnp-2911	232	31	possible	possible	ADJ
fnp-2911	232	32	using	use	VERB
fnp-2911	232	33	fac	fac	NOUN
fnp-2911	232	34	sorting	sorting	NOUN
fnp-2911	232	35	approaches	approach	NOUN
fnp-2911	232	36	.	.	PUNCT
fnp-2911	233	1	additional	additional	ADJ
fnp-2911	233	2	future	future	ADJ
fnp-2911	233	3	studies	study	NOUN
fnp-2911	233	4	can	can	AUX
fnp-2911	233	5	also	also	ADV
fnp-2911	233	6	include	include	VERB
fnp-2911	233	7	comparisons	comparison	NOUN
fnp-2911	233	8	between	between	ADP
fnp-2911	233	9	als	al	NOUN
fnp-2911	233	10	/	/	SYM
fnp-2911	233	11	ftd	ftd	NOUN
fnp-2911	233	12	cases	case	NOUN
fnp-2911	233	13	with	with	ADP
fnp-2911	233	14	and	and	CCONJ
fnp-2911	233	15	without	without	ADP
fnp-2911	233	16	the	the	DET
fnp-2911	233	17	c9orf72	c9orf72	PROPN
fnp-2911	233	18	mutation	mutation	NOUN
fnp-2911	233	19	.	.	PUNCT
fnp-2911	234	1	genes	gene	NOUN
fnp-2911	234	2	related	relate	VERB
fnp-2911	234	3	to	to	ADP
fnp-2911	234	4	dna	dna	PROPN
fnp-2911	234	5	repair	repair	NOUN
fnp-2911	234	6	either	either	CCONJ
fnp-2911	234	7	as	as	ADP
fnp-2911	234	8	a	a	DET
fnp-2911	234	9	response	response	NOUN
fnp-2911	234	10	to	to	ADP
fnp-2911	234	11	dna	dna	PROPN
fnp-2911	234	12	damage	damage	NOUN
fnp-2911	234	13	or	or	CCONJ
fnp-2911	234	14	important	important	ADJ
fnp-2911	234	15	to	to	PART
fnp-2911	234	16	employ	employ	VERB
fnp-2911	234	17	dna	dna	PROPN
fnp-2911	234	18	repair	repair	NOUN
fnp-2911	234	19	were	be	AUX
fnp-2911	234	20	also	also	ADV
fnp-2911	234	21	dysregulated	dysregulate	VERB
fnp-2911	234	22	.	.	PUNCT
fnp-2911	235	1	interestingly	interestingly	ADV
fnp-2911	235	2	,	,	PUNCT
fnp-2911	235	3	recent	recent	ADJ
fnp-2911	235	4	papers	paper	NOUN
fnp-2911	235	5	have	have	AUX
fnp-2911	235	6	shown	show	VERB
fnp-2911	235	7	that	that	SCONJ
fnp-2911	235	8	dna	dna	PROPN
fnp-2911	235	9	damage	damage	NOUN
fnp-2911	235	10	is	be	AUX
fnp-2911	235	11	activated	activate	VERB
fnp-2911	235	12	by	by	ADP
fnp-2911	235	13	the	the	DET
fnp-2911	235	14	c9orf72	c9orf72	PROPN
fnp-2911	235	15	repeat	repeat	NOUN
fnp-2911	235	16	expansion	expansion	NOUN
fnp-2911	235	17	in	in	ADP
fnp-2911	235	18	both	both	DET
fnp-2911	235	19	als	als	NOUN
fnp-2911	235	20	patients	patient	NOUN
fnp-2911	235	21	and	and	CCONJ
fnp-2911	235	22	experimental	experimental	ADJ
fnp-2911	235	23	models	model	NOUN
fnp-2911	235	24	(	(	PUNCT
fnp-2911	235	25	23	23	NUM
fnp-2911	235	26	,	,	PUNCT
fnp-2911	235	27	25	25	NUM
fnp-2911	235	28	,	,	PUNCT
fnp-2911	235	29	26	26	NUM
fnp-2911	235	30	,	,	PUNCT
fnp-2911	235	31	30	30	NUM
fnp-2911	235	32	,	,	PUNCT
fnp-2911	235	33	68	68	NUM
fnp-2911	235	34	)	)	PUNCT
fnp-2911	235	35	.	.	PUNCT
fnp-2911	236	1	dna	dna	PROPN
fnp-2911	236	2	damage	damage	NOUN
fnp-2911	236	3	has	have	AUX
fnp-2911	236	4	been	be	AUX
fnp-2911	236	5	a	a	DET
fnp-2911	236	6	consistent	consistent	ADJ
fnp-2911	236	7	feature	feature	NOUN
fnp-2911	236	8	among	among	ADP
fnp-2911	236	9	trinucleotide	trinucleotide	ADJ
fnp-2911	236	10	repeat	repeat	NOUN
fnp-2911	236	11	expansion	expansion	NOUN
fnp-2911	236	12	diseases	disease	NOUN
fnp-2911	236	13	and	and	CCONJ
fnp-2911	236	14	the	the	DET
fnp-2911	236	15	dysregulation	dysregulation	NOUN
fnp-2911	236	16	of	of	ADP
fnp-2911	236	17	dna	dna	PROPN
fnp-2911	236	18	repair	repair	VERB
fnp-2911	236	19	related	related	ADJ
fnp-2911	236	20	genes	gene	NOUN
fnp-2911	236	21	is	be	AUX
fnp-2911	236	22	consistent	consistent	ADJ
fnp-2911	236	23	with	with	ADP
fnp-2911	236	24	dna	dna	PROPN
fnp-2911	236	25	damage	damage	NOUN
fnp-2911	236	26	contributing	contribute	VERB
fnp-2911	236	27	to	to	ADP
fnp-2911	236	28	neurodegeneration	neurodegeneration	NOUN
fnp-2911	236	29	(	(	PUNCT
fnp-2911	236	30	69	69	NUM
fnp-2911	236	31	)	)	PUNCT
fnp-2911	236	32	.	.	PUNCT
fnp-2911	237	1	furthermore	furthermore	ADV
fnp-2911	237	2	,	,	PUNCT
fnp-2911	237	3	alterations	alteration	NOUN
fnp-2911	237	4	in	in	ADP
fnp-2911	237	5	proteostasis	proteostasis	NOUN
fnp-2911	237	6	either	either	CCONJ
fnp-2911	237	7	by	by	ADP
fnp-2911	237	8	failure	failure	NOUN
fnp-2911	237	9	to	to	PART
fnp-2911	237	10	fold	fold	VERB
fnp-2911	237	11	proteins	protein	NOUN
fnp-2911	237	12	properly	properly	ADV
fnp-2911	237	13	or	or	CCONJ
fnp-2911	237	14	failure	failure	NOUN
fnp-2911	237	15	to	to	PART
fnp-2911	237	16	degrade	degrade	VERB
fnp-2911	237	17	proteins	protein	NOUN
fnp-2911	237	18	likely	likely	ADV
fnp-2911	237	19	contribute	contribute	VERB
fnp-2911	237	20	to	to	ADP
fnp-2911	237	21	protein	protein	NOUN
fnp-2911	237	22	aggregation	aggregation	NOUN
fnp-2911	237	23	and	and	CCONJ
fnp-2911	237	24	are	be	AUX
fnp-2911	237	25	a	a	DET
fnp-2911	237	26	common	common	ADJ
fnp-2911	237	27	theme	theme	NOUN
fnp-2911	237	28	among	among	ADP
fnp-2911	237	29	all	all	DET
fnp-2911	237	30	neurodegenerative	neurodegenerative	ADJ
fnp-2911	237	31	diseases	disease	NOUN
fnp-2911	237	32	(	(	PUNCT
fnp-2911	237	33	70	70	NUM
fnp-2911	237	34	,	,	PUNCT
fnp-2911	237	35	71	71	NUM
fnp-2911	237	36	)	)	PUNCT
fnp-2911	237	37	.	.	PUNCT
fnp-2911	238	1	indeed	indeed	ADV
fnp-2911	238	2	,	,	PUNCT
fnp-2911	238	3	overexpressing	overexpresse	VERB
fnp-2911	238	4	proteostasis	proteostasis	NOUN
fnp-2911	238	5	factors	factor	NOUN
fnp-2911	238	6	in	in	ADP
fnp-2911	238	7	animal	animal	NOUN
fnp-2911	238	8	and	and	CCONJ
fnp-2911	238	9	cell	cell	NOUN
fnp-2911	238	10	als	als	NOUN
fnp-2911	238	11	models	model	NOUN
fnp-2911	238	12	prevents	prevent	VERB
fnp-2911	238	13	protein	protein	NOUN
fnp-2911	238	14	accumulation	accumulation	NOUN
fnp-2911	238	15	and	and	CCONJ
fnp-2911	238	16	aggregation	aggregation	NOUN
fnp-2911	238	17	(	(	PUNCT
fnp-2911	238	18	57	57	NUM
fnp-2911	238	19	,	,	PUNCT
fnp-2911	238	20	72	72	NUM
fnp-2911	238	21	,	,	PUNCT
fnp-2911	238	22	73	73	NUM
fnp-2911	238	23	)	)	PUNCT
fnp-2911	238	24	,	,	PUNCT
fnp-2911	238	25	suggesting	suggest	VERB
fnp-2911	238	26	that	that	SCONJ
fnp-2911	238	27	altered	altered	ADJ
fnp-2911	238	28	proteostasis	proteostasis	NOUN
fnp-2911	238	29	activity	activity	NOUN
fnp-2911	238	30	contributes	contribute	VERB
fnp-2911	238	31	to	to	ADP
fnp-2911	238	32	neurodegeneration	neurodegeneration	NOUN
fnp-2911	238	33	.	.	PUNCT
fnp-2911	239	1	thus	thus	ADV
fnp-2911	239	2	,	,	PUNCT
fnp-2911	239	3	although	although	SCONJ
fnp-2911	239	4	the	the	DET
fnp-2911	239	5	global	global	ADJ
fnp-2911	239	6	transcriptome	transcriptome	NOUN
fnp-2911	239	7	appears	appear	VERB
fnp-2911	239	8	to	to	PART
fnp-2911	239	9	be	be	AUX
fnp-2911	239	10	driven	drive	VERB
fnp-2911	239	11	by	by	ADP
fnp-2911	239	12	the	the	DET
fnp-2911	239	13	loss	loss	NOUN
fnp-2911	239	14	of	of	ADP
fnp-2911	239	15	c9orf72	c9orf72	PROPN
fnp-2911	239	16	function	function	NOUN
fnp-2911	239	17	,	,	PUNCT
fnp-2911	239	18	embedded	embed	VERB
fnp-2911	239	19	within	within	ADP
fnp-2911	239	20	the	the	DET
fnp-2911	239	21	c9orf72	c9orf72	ADJ
fnp-2911	239	22	transcriptome	transcriptome	NOUN
fnp-2911	239	23	are	be	AUX
fnp-2911	239	24	changes	change	NOUN
fnp-2911	239	25	in	in	ADP
fnp-2911	239	26	gene	gene	NOUN
fnp-2911	239	27	expression	expression	NOUN
fnp-2911	239	28	,	,	PUNCT
fnp-2911	239	29	which	which	PRON
fnp-2911	239	30	may	may	AUX
fnp-2911	239	31	relate	relate	VERB
fnp-2911	239	32	to	to	ADP
fnp-2911	239	33	the	the	DET
fnp-2911	239	34	toxic	toxic	ADJ
fnp-2911	239	35	functions	function	NOUN
fnp-2911	239	36	of	of	ADP
fnp-2911	239	37	c9orf72	c9orf72	PROPN
fnp-2911	239	38	.	.	PUNCT
fnp-2911	240	1	in	in	ADP
fnp-2911	240	2	comparing	compare	VERB
fnp-2911	240	3	the	the	DET
fnp-2911	240	4	data	datum	NOUN
fnp-2911	240	5	from	from	ADP
fnp-2911	240	6	previous	previous	ADJ
fnp-2911	240	7	transcriptome	transcriptome	ADJ
fnp-2911	240	8	analyses	analysis	NOUN
fnp-2911	240	9	from	from	ADP
fnp-2911	240	10	c9orf72	c9orf72	ADJ
fnp-2911	240	11	expansion	expansion	NOUN
fnp-2911	240	12	carriers	carrier	NOUN
fnp-2911	240	13	,	,	PUNCT
fnp-2911	240	14	several	several	ADJ
fnp-2911	240	15	differences	difference	NOUN
fnp-2911	240	16	can	can	AUX
fnp-2911	240	17	be	be	AUX
fnp-2911	240	18	observed	observe	VERB
fnp-2911	240	19	.	.	PUNCT
fnp-2911	241	1	previous	previous	ADJ
fnp-2911	241	2	transcriptome	transcriptome	ADJ
fnp-2911	241	3	analyses	analysis	NOUN
fnp-2911	241	4	have	have	AUX
fnp-2911	241	5	identified	identify	VERB
fnp-2911	241	6	pathways	pathway	NOUN
fnp-2911	241	7	involved	involve	VERB
fnp-2911	241	8	in	in	ADP
fnp-2911	241	9	inflammation	inflammation	NOUN
fnp-2911	241	10	and	and	CCONJ
fnp-2911	241	11	defense	defense	NOUN
fnp-2911	241	12	responses	response	NOUN
fnp-2911	241	13	among	among	ADP
fnp-2911	241	14	dysregulated	dysregulated	ADJ
fnp-2911	241	15	genes	gene	NOUN
fnp-2911	241	16	in	in	ADP
fnp-2911	241	17	the	the	DET
fnp-2911	241	18	frontal	frontal	ADJ
fnp-2911	241	19	cortices	cortex	NOUN
fnp-2911	241	20	from	from	ADP
fnp-2911	241	21	c9orf72	c9orf72	ADJ
fnp-2911	241	22	expansion	expansion	NOUN
fnp-2911	241	23	carriers	carrier	NOUN
fnp-2911	241	24	(	(	PUNCT
fnp-2911	241	25	49	49	NUM
fnp-2911	241	26	)	)	PUNCT
fnp-2911	241	27	.	.	PUNCT
fnp-2911	242	1	within	within	ADP
fnp-2911	242	2	our	our	PRON
fnp-2911	242	3	dataset	dataset	NOUN
fnp-2911	242	4	,	,	PUNCT
fnp-2911	242	5	we	we	PRON
fnp-2911	242	6	did	do	AUX
fnp-2911	242	7	not	not	PART
fnp-2911	242	8	find	find	VERB
fnp-2911	242	9	enriched	enriched	ADJ
fnp-2911	242	10	inflammatory	inflammatory	ADJ
fnp-2911	242	11	pathways	pathway	NOUN
fnp-2911	242	12	,	,	PUNCT
fnp-2911	242	13	which	which	PRON
fnp-2911	242	14	is	be	AUX
fnp-2911	242	15	likely	likely	ADJ
fnp-2911	242	16	due	due	ADP
fnp-2911	242	17	to	to	ADP
fnp-2911	242	18	the	the	DET
fnp-2911	242	19	fact	fact	NOUN
fnp-2911	242	20	that	that	SCONJ
fnp-2911	242	21	only	only	ADJ
fnp-2911	242	22	neurons	neuron	NOUN
fnp-2911	242	23	were	be	AUX
fnp-2911	242	24	being	be	AUX
fnp-2911	242	25	sequenced	sequence	VERB
fnp-2911	242	26	.	.	PUNCT
fnp-2911	243	1	it	it	PRON
fnp-2911	243	2	is	be	AUX
fnp-2911	243	3	possible	possible	ADJ
fnp-2911	243	4	that	that	SCONJ
fnp-2911	243	5	because	because	SCONJ
fnp-2911	243	6	c9orf72	c9orf72	PROPN
fnp-2911	243	7	is	be	AUX
fnp-2911	243	8	expressed	express	VERB
fnp-2911	243	9	in	in	ADP
fnp-2911	243	10	microglia	microglia	ADJ
fnp-2911	243	11	,	,	PUNCT
fnp-2911	243	12	c9orf72	c9orf72	ADJ
fnp-2911	243	13	protein	protein	NOUN
fnp-2911	243	14	function	function	NOUN
fnp-2911	243	15	may	may	AUX
fnp-2911	243	16	have	have	VERB
fnp-2911	243	17	a	a	DET
fnp-2911	243	18	larger	large	ADJ
fnp-2911	243	19	effect	effect	NOUN
fnp-2911	243	20	on	on	ADP
fnp-2911	243	21	microglial	microglial	ADJ
fnp-2911	243	22	populations	population	NOUN
fnp-2911	243	23	(	(	PUNCT
fnp-2911	243	24	41	41	NUM
fnp-2911	243	25	)	)	PUNCT
fnp-2911	243	26	.	.	PUNCT
fnp-2911	244	1	given	give	VERB
fnp-2911	244	2	the	the	DET
fnp-2911	244	3	evidence	evidence	NOUN
fnp-2911	244	4	supporting	support	VERB
fnp-2911	244	5	that	that	DET
fnp-2911	244	6	c9orf72	c9orf72	PROPN
fnp-2911	244	7	is	be	AUX
fnp-2911	244	8	involved	involve	VERB
fnp-2911	244	9	inflammatory	inflammatory	ADJ
fnp-2911	244	10	processes	process	NOUN
fnp-2911	244	11	,	,	PUNCT
fnp-2911	244	12	further	further	ADJ
fnp-2911	244	13	cell	cell	NOUN
fnp-2911	244	14	-	-	PUNCT
fnp-2911	244	15	specific	specific	ADJ
fnp-2911	244	16	analyses	analysis	NOUN
fnp-2911	244	17	may	may	AUX
fnp-2911	244	18	prove	prove	VERB
fnp-2911	244	19	beneficial	beneficial	ADJ
fnp-2911	244	20	to	to	ADP
fnp-2911	244	21	better	well	ADV
fnp-2911	244	22	understanding	understand	VERB
fnp-2911	244	23	the	the	DET
fnp-2911	244	24	effects	effect	NOUN
fnp-2911	244	25	of	of	ADP
fnp-2911	244	26	mutant	mutant	ADJ
fnp-2911	244	27	c9orf72	c9orf72	PROPN
fnp-2911	244	28	on	on	ADP
fnp-2911	244	29	non	non	ADJ
fnp-2911	244	30	-	-	ADJ
fnp-2911	244	31	neuronal	neuronal	ADJ
fnp-2911	244	32	cells	cell	NOUN
fnp-2911	244	33	in	in	ADP
fnp-2911	244	34	driving	drive	VERB
fnp-2911	244	35	disease	disease	NOUN
fnp-2911	244	36	pathogenesis	pathogenesis	NOUN
fnp-2911	244	37	.	.	PUNCT
fnp-2911	245	1	previous	previous	ADJ
fnp-2911	245	2	studies	study	NOUN
fnp-2911	245	3	have	have	AUX
fnp-2911	245	4	found	find	VERB
fnp-2911	245	5	large	large	ADJ
fnp-2911	245	6	numbers	number	NOUN
fnp-2911	245	7	of	of	ADP
fnp-2911	245	8	splicing	splicing	NOUN
fnp-2911	245	9	changes	change	NOUN
fnp-2911	245	10	in	in	ADP
fnp-2911	245	11	c9orf72	c9orf72	ADJ
fnp-2911	245	12	expansion	expansion	NOUN
fnp-2911	245	13	carriers	carrier	NOUN
fnp-2911	245	14	and	and	CCONJ
fnp-2911	245	15	found	find	VERB
fnp-2911	245	16	motifs	motif	NOUN
fnp-2911	245	17	within	within	ADP
fnp-2911	245	18	these	these	DET
fnp-2911	245	19	splicing	splicing	NOUN
fnp-2911	245	20	changes	change	NOUN
fnp-2911	245	21	that	that	PRON
fnp-2911	245	22	correspond	correspond	VERB
fnp-2911	245	23	to	to	ADP
fnp-2911	245	24	hnrnp	hnrnp	PROPN
fnp-2911	245	25	h	h	PROPN
fnp-2911	245	26	binding	bind	VERB
fnp-2911	245	27	(	(	PUNCT
fnp-2911	245	28	49	49	NUM
fnp-2911	245	29	)	)	PUNCT
fnp-2911	245	30	.	.	PUNCT
fnp-2911	246	1	however	however	ADV
fnp-2911	246	2	,	,	PUNCT
fnp-2911	246	3	we	we	PRON
fnp-2911	246	4	did	do	AUX
fnp-2911	246	5	not	not	PART
fnp-2911	246	6	detect	detect	VERB
fnp-2911	246	7	such	such	ADJ
fnp-2911	246	8	large	large	ADJ
fnp-2911	246	9	changes	change	NOUN
fnp-2911	246	10	and	and	CCONJ
fnp-2911	246	11	instead	instead	ADV
fnp-2911	246	12	found	find	VERB
fnp-2911	246	13	milder	mild	ADJ
fnp-2911	246	14	splicing	splicing	NOUN
fnp-2911	246	15	changes	change	NOUN
fnp-2911	246	16	with	with	ADP
fnp-2911	246	17	motifs	motif	NOUN
fnp-2911	246	18	that	that	PRON
fnp-2911	246	19	do	do	AUX
fnp-2911	246	20	not	not	PART
fnp-2911	246	21	correspond	correspond	VERB
fnp-2911	246	22	to	to	ADP
fnp-2911	246	23	any	any	DET
fnp-2911	246	24	known	know	VERB
fnp-2911	246	25	rna	rna	NOUN
fnp-2911	246	26	foci	focus	NOUN
fnp-2911	246	27	colocalization	colocalization	NOUN
fnp-2911	246	28	partners	partner	NOUN
fnp-2911	246	29	(	(	PUNCT
fnp-2911	246	30	data	datum	NOUN
fnp-2911	246	31	not	not	PART
fnp-2911	246	32	shown	show	VERB
fnp-2911	246	33	)	)	PUNCT
fnp-2911	246	34	.	.	PUNCT
fnp-2911	247	1	current	current	ADJ
fnp-2911	247	2	studies	study	NOUN
fnp-2911	247	3	debated	debate	VERB
fnp-2911	247	4	over	over	ADP
fnp-2911	247	5	the	the	DET
fnp-2911	247	6	disease	disease	NOUN
fnp-2911	247	7	relevance	relevance	NOUN
fnp-2911	247	8	of	of	ADP
fnp-2911	247	9	rna	rna	NOUN
fnp-2911	247	10	foci	focus	NOUN
fnp-2911	247	11	as	as	SCONJ
fnp-2911	247	12	some	some	DET
fnp-2911	247	13	animal	animal	NOUN
fnp-2911	247	14	models	model	NOUN
fnp-2911	247	15	overexpressing	overexpresse	VERB
fnp-2911	247	16	the	the	DET
fnp-2911	247	17	repeat	repeat	NOUN
fnp-2911	247	18	induce	induce	VERB
fnp-2911	247	19	rna	rna	NOUN
fnp-2911	247	20	foci	focus	NOUN
fnp-2911	247	21	but	but	CCONJ
fnp-2911	247	22	do	do	AUX
fnp-2911	247	23	not	not	PART
fnp-2911	247	24	show	show	VERB
fnp-2911	247	25	motor	motor	NOUN
fnp-2911	247	26	or	or	CCONJ
fnp-2911	247	27	cognitive	cognitive	ADJ
fnp-2911	247	28	defects	defect	NOUN
fnp-2911	247	29	(	(	PUNCT
fnp-2911	247	30	13	13	NUM
fnp-2911	247	31	-	-	SYM
fnp-2911	247	32	16	16	NUM
fnp-2911	247	33	)	)	PUNCT
fnp-2911	247	34	.	.	PUNCT
fnp-2911	248	1	the	the	DET
fnp-2911	248	2	lack	lack	NOUN
fnp-2911	248	3	of	of	ADP
fnp-2911	248	4	splicing	splicing	NOUN
fnp-2911	248	5	changes	change	NOUN
fnp-2911	248	6	in	in	ADP
fnp-2911	248	7	our	our	PRON
fnp-2911	248	8	dataset	dataset	NOUN
fnp-2911	248	9	does	do	AUX
fnp-2911	248	10	not	not	PART
fnp-2911	248	11	support	support	VERB
fnp-2911	248	12	the	the	DET
fnp-2911	248	13	model	model	NOUN
fnp-2911	248	14	wherein	wherein	ADJ
fnp-2911	248	15	neuronal	neuronal	ADJ
fnp-2911	248	16	toxicity	toxicity	NOUN
fnp-2911	248	17	is	be	AUX
fnp-2911	248	18	linked	link	VERB
fnp-2911	248	19	to	to	ADP
fnp-2911	248	20	the	the	DET
fnp-2911	248	21	titration	titration	NOUN
fnp-2911	248	22	of	of	ADP
fnp-2911	248	23	rna	rna	NOUN
fnp-2911	248	24	binding	bind	VERB
fnp-2911	248	25	proteins	protein	NOUN
fnp-2911	248	26	within	within	ADP
fnp-2911	248	27	rna	rna	NOUN
fnp-2911	248	28	foci	focus	NOUN
fnp-2911	248	29	.	.	PUNCT
fnp-2911	249	1	overall	overall	ADV
fnp-2911	249	2	,	,	PUNCT
fnp-2911	249	3	our	our	PRON
fnp-2911	249	4	findings	finding	NOUN
fnp-2911	249	5	argue	argue	VERB
fnp-2911	249	6	against	against	ADP
fnp-2911	249	7	rna	rna	NOUN
fnp-2911	249	8	toxicity	toxicity	NOUN
fnp-2911	249	9	attributed	attribute	VERB
fnp-2911	249	10	to	to	ADP
fnp-2911	249	11	sequestration	sequestration	NOUN
fnp-2911	249	12	of	of	ADP
fnp-2911	249	13	rna	rna	NOUN
fnp-2911	249	14	binding	binding	ADJ
fnp-2911	249	15	proteins	protein	NOUN
fnp-2911	249	16	.	.	PUNCT
fnp-2911	250	1	other	other	ADJ
fnp-2911	250	2	disease	disease	NOUN
fnp-2911	250	3	-	-	PUNCT
fnp-2911	250	4	related	relate	VERB
fnp-2911	250	5	pathways	pathway	NOUN
fnp-2911	250	6	,	,	PUNCT
fnp-2911	250	7	such	such	ADJ
fnp-2911	250	8	as	as	ADP
fnp-2911	250	9	protein	protein	NOUN
fnp-2911	250	10	aggregation	aggregation	NOUN
fnp-2911	250	11	and	and	CCONJ
fnp-2911	250	12	dna	dna	PROPN
fnp-2911	250	13	repair	repair	NOUN
fnp-2911	250	14	,	,	PUNCT
fnp-2911	250	15	were	be	AUX
fnp-2911	250	16	observed	observe	VERB
fnp-2911	250	17	in	in	ADP
fnp-2911	250	18	this	this	DET
fnp-2911	250	19	dataset	dataset	NOUN
fnp-2911	250	20	,	,	PUNCT
fnp-2911	250	21	supporting	support	VERB
fnp-2911	250	22	a	a	DET
fnp-2911	250	23	potential	potential	ADJ
fnp-2911	250	24	role	role	NOUN
fnp-2911	250	25	for	for	ADP
fnp-2911	250	26	dipeptide	dipeptide	NOUN
fnp-2911	250	27	repeat	repeat	NOUN
fnp-2911	250	28	protein	protein	NOUN
fnp-2911	250	29	aggregates	aggregate	NOUN
fnp-2911	250	30	and	and	CCONJ
fnp-2911	250	31	nuclear	nuclear	ADJ
fnp-2911	250	32	dna	dna	NOUN
fnp-2911	250	33	damage	damage	NOUN
fnp-2911	250	34	in	in	ADP
fnp-2911	250	35	disease	disease	NOUN
fnp-2911	250	36	,	,	PUNCT
fnp-2911	250	37	consistent	consistent	ADJ
fnp-2911	250	38	with	with	ADP
fnp-2911	250	39	experimental	experimental	ADJ
fnp-2911	250	40	studies	study	NOUN
fnp-2911	250	41	showing	show	VERB
fnp-2911	250	42	that	that	SCONJ
fnp-2911	250	43	overexpression	overexpression	NOUN
fnp-2911	250	44	of	of	ADP
fnp-2911	250	45	dipeptide	dipeptide	NOUN
fnp-2911	250	46	repeat	repeat	NOUN
fnp-2911	250	47	proteins	protein	NOUN
fnp-2911	250	48	are	be	AUX
fnp-2911	250	49	toxic	toxic	ADJ
fnp-2911	250	50	both	both	CCONJ
fnp-2911	250	51	in	in	ADP
fnp-2911	250	52	cells	cell	NOUN
fnp-2911	250	53	and	and	CCONJ
fnp-2911	250	54	in	in	ADP
fnp-2911	250	55	animal	animal	NOUN
fnp-2911	250	56	models	model	NOUN
fnp-2911	250	57	(	(	PUNCT
fnp-2911	250	58	13	13	NUM
fnp-2911	250	59	-	-	SYM
fnp-2911	250	60	32	32	NUM
fnp-2911	250	61	)	)	PUNCT
fnp-2911	250	62	.	.	PUNCT
fnp-2911	251	1	while	while	SCONJ
fnp-2911	251	2	the	the	DET
fnp-2911	251	3	transcriptome	transcriptome	NOUN
fnp-2911	251	4	appeared	appear	VERB
fnp-2911	251	5	to	to	PART
fnp-2911	251	6	be	be	AUX
fnp-2911	251	7	shaped	shape	VERB
fnp-2911	251	8	in	in	ADP
fnp-2911	251	9	large	large	ADJ
fnp-2911	251	10	part	part	NOUN
fnp-2911	251	11	by	by	ADP
fnp-2911	251	12	the	the	DET
fnp-2911	251	13	loss	loss	NOUN
fnp-2911	251	14	of	of	ADP
fnp-2911	251	15	c9orf72	c9orf72	PROPN
fnp-2911	251	16	function	function	NOUN
fnp-2911	251	17	,	,	PUNCT
fnp-2911	251	18	it	it	PRON
fnp-2911	251	19	is	be	AUX
fnp-2911	251	20	unclear	unclear	ADJ
fnp-2911	251	21	whether	whether	SCONJ
fnp-2911	251	22	the	the	DET
fnp-2911	251	23	loss	loss	NOUN
fnp-2911	251	24	of	of	ADP
fnp-2911	251	25	c9orf72	c9orf72	PROPN
fnp-2911	251	26	function	function	NOUN
fnp-2911	251	27	contributes	contribute	VERB
fnp-2911	251	28	to	to	ADP
fnp-2911	251	29	disease	disease	NOUN
fnp-2911	251	30	and	and	CCONJ
fnp-2911	251	31	thus	thus	ADV
fnp-2911	251	32	understanding	understand	VERB
fnp-2911	251	33	whether	whether	SCONJ
fnp-2911	251	34	these	these	DET
fnp-2911	251	35	changes	change	NOUN
fnp-2911	251	36	are	be	AUX
fnp-2911	251	37	functionally	functionally	ADV
fnp-2911	251	38	linked	link	VERB
fnp-2911	251	39	to	to	ADP
fnp-2911	251	40	disease	disease	NOUN
fnp-2911	251	41	pathogenesis	pathogenesis	NOUN
fnp-2911	251	42	requires	require	VERB
fnp-2911	251	43	additional	additional	ADJ
fnp-2911	251	44	experimental	experimental	ADJ
fnp-2911	251	45	studies	study	NOUN
fnp-2911	251	46	and	and	CCONJ
fnp-2911	251	47	validation	validation	NOUN
fnp-2911	251	48	.	.	PUNCT
fnp-2911	252	1	finally	finally	ADV
fnp-2911	252	2	,	,	PUNCT
fnp-2911	252	3	our	our	PRON
fnp-2911	252	4	analysis	analysis	NOUN
fnp-2911	252	5	highlights	highlight	VERB
fnp-2911	252	6	the	the	DET
fnp-2911	252	7	complexities	complexity	NOUN
fnp-2911	252	8	associated	associate	VERB
fnp-2911	252	9	with	with	ADP
fnp-2911	252	10	molecular	molecular	ADJ
fnp-2911	252	11	studies	study	NOUN
fnp-2911	252	12	of	of	ADP
fnp-2911	252	13	post	post	ADJ
fnp-2911	252	14	-	-	ADJ
fnp-2911	252	15	mortem	mortem	ADJ
fnp-2911	252	16	human	human	ADJ
fnp-2911	252	17	tissue	tissue	NOUN
fnp-2911	252	18	wherein	wherein	ADJ
fnp-2911	252	19	issues	issue	NOUN
fnp-2911	252	20	related	relate	VERB
fnp-2911	252	21	to	to	ADP
fnp-2911	252	22	cell	cell	NOUN
fnp-2911	252	23	identity	identity	NOUN
fnp-2911	252	24	,	,	PUNCT
fnp-2911	252	25	experimental	experimental	ADJ
fnp-2911	252	26	design	design	NOUN
fnp-2911	252	27	,	,	PUNCT
fnp-2911	252	28	and	and	CCONJ
fnp-2911	252	29	admixtures	admixture	NOUN
fnp-2911	252	30	of	of	ADP
fnp-2911	252	31	both	both	DET
fnp-2911	252	32	gain	gain	NOUN
fnp-2911	252	33	and	and	CCONJ
fnp-2911	252	34	loss	loss	NOUN
fnp-2911	252	35	of	of	ADP
fnp-2911	252	36	function	function	NOUN
fnp-2911	252	37	effects	effect	NOUN
fnp-2911	252	38	can	can	AUX
fnp-2911	252	39	be	be	AUX
fnp-2911	252	40	seen	see	VERB
fnp-2911	252	41	concurrently	concurrently	ADV
fnp-2911	252	42	.	.	PUNCT
fnp-2911	253	1	contributions	contribution	NOUN
fnp-2911	253	2	and	and	CCONJ
fnp-2911	253	3	acknowledgements	acknowledgement	NOUN
fnp-2911	253	4	these	these	DET
fnp-2911	253	5	studies	study	NOUN
fnp-2911	253	6	were	be	AUX
fnp-2911	253	7	supported	support	VERB
fnp-2911	253	8	by	by	ADP
fnp-2911	253	9	a	a	DET
fnp-2911	253	10	grant	grant	NOUN
fnp-2911	253	11	from	from	ADP
fnp-2911	253	12	the	the	DET
fnp-2911	253	13	judith	judith	PROPN
fnp-2911	253	14	&	&	CCONJ
fnp-2911	253	15	jean	jean	PROPN
fnp-2911	253	16	pape	pape	PROPN
fnp-2911	253	17	adams	adams	PROPN
fnp-2911	253	18	charitable	charitable	PROPN
fnp-2911	253	19	foundation	foundation	PROPN
fnp-2911	253	20	,	,	PUNCT
fnp-2911	253	21	a	a	DET
fnp-2911	253	22	clinical	clinical	ADJ
fnp-2911	253	23	scientist	scientist	NOUN
fnp-2911	253	24	development	development	NOUN
fnp-2911	253	25	grant	grant	NOUN
fnp-2911	253	26	from	from	ADP
fnp-2911	253	27	the	the	DET
fnp-2911	253	28	doris	doris	PROPN
fnp-2911	253	29	duke	duke	PROPN
fnp-2911	253	30	charitable	charitable	PROPN
fnp-2911	253	31	foundation	foundation	PROPN
fnp-2911	253	32	,	,	PUNCT
fnp-2911	253	33	and	and	CCONJ
fnp-2911	253	34	nih	nih	PROPN
fnp-2911	253	35	grants	grant	NOUN
fnp-2911	253	36	(	(	PUNCT
fnp-2911	253	37	t32	t32	NOUN
fnp-2911	253	38	ag000255	ag000255	NOUN
fnp-2911	253	39	,	,	PUNCT
fnp-2911	253	40	r21	r21	NOUN
fnp-2911	253	41	ns097749	ns097749	NOUN
fnp-2911	253	42	,	,	PUNCT
fnp-2911	253	43	r01	r01	PROPN
fnp-2911	253	44	ns095793	ns095793	NOUN
fnp-2911	253	45	,	,	PUNCT
fnp-2911	253	46	p01	p01	NOUN
fnp-2911	253	47	ag017586	ag017586	NOUN
fnp-2911	253	48	,	,	PUNCT
fnp-2911	253	49	and	and	CCONJ
fnp-2911	253	50	p30	p30	PROPN
fnp-2911	253	51	ag010124	ag010124	PROPN
fnp-2911	253	52	)	)	PUNCT
fnp-2911	253	53	.	.	PUNCT
fnp-2911	254	1	we	we	PRON
fnp-2911	254	2	thank	thank	VERB
fnp-2911	254	3	paul	paul	PROPN
fnp-2911	254	4	hallberg	hallberg	PROPN
fnp-2911	254	5	from	from	ADP
fnp-2911	254	6	the	the	DET
fnp-2911	254	7	university	university	PROPN
fnp-2911	254	8	of	of	ADP
fnp-2911	254	9	pennsylvania	pennsylvania	PROPN
fnp-2911	254	10	flow	flow	PROPN
fnp-2911	254	11	cytometry	cytometry	NOUN
fnp-2911	254	12	core	core	NOUN
fnp-2911	254	13	for	for	ADP
fnp-2911	254	14	technical	technical	ADJ
fnp-2911	254	15	assistance	assistance	NOUN
fnp-2911	254	16	,	,	PUNCT
fnp-2911	254	17	and	and	CCONJ
fnp-2911	254	18	the	the	DET
fnp-2911	254	19	center	center	NOUN
fnp-2911	254	20	for	for	ADP
fnp-2911	254	21	neurodegenerative	neurodegenerative	ADJ
fnp-2911	254	22	disease	disease	NOUN
fnp-2911	254	23	at	at	ADP
fnp-2911	254	24	the	the	DET
fnp-2911	254	25	university	university	PROPN
fnp-2911	254	26	of	of	ADP
fnp-2911	254	27	pennsylvania	pennsylvania	PROPN
fnp-2911	254	28	for	for	ADP
fnp-2911	254	29	their	their	PRON
fnp-2911	254	30	support	support	NOUN
fnp-2911	254	31	.	.	PUNCT
fnp-2911	255	1	we	we	PRON
fnp-2911	255	2	are	be	AUX
fnp-2911	255	3	indebted	indebted	ADJ
fnp-2911	255	4	to	to	ADP
fnp-2911	255	5	the	the	DET
fnp-2911	255	6	patients	patient	NOUN
fnp-2911	255	7	,	,	PUNCT
fnp-2911	255	8	caretakers	caretaker	NOUN
fnp-2911	255	9	,	,	PUNCT
fnp-2911	255	10	families	family	NOUN
fnp-2911	255	11	,	,	PUNCT
fnp-2911	255	12	and	and	CCONJ
fnp-2911	255	13	physicians	physician	NOUN
fnp-2911	255	14	,	,	PUNCT
fnp-2911	255	15	for	for	ADP
fnp-2911	255	16	without	without	ADP
fnp-2911	255	17	their	their	PRON
fnp-2911	255	18	meaningful	meaningful	ADJ
fnp-2911	255	19	contributions	contribution	NOUN
fnp-2911	255	20	and	and	CCONJ
fnp-2911	255	21	dedication	dedication	NOUN
fnp-2911	255	22	to	to	ADP
fnp-2911	255	23	medical	medical	ADJ
fnp-2911	255	24	research	research	NOUN
fnp-2911	255	25	this	this	DET
fnp-2911	255	26	work	work	NOUN
fnp-2911	255	27	would	would	AUX
fnp-2911	255	28	not	not	PART
fnp-2911	255	29	be	be	AUX
fnp-2911	255	30	possible	possible	ADJ
fnp-2911	255	31	.	.	PUNCT
fnp-2911	256	1	references	reference	NOUN
fnp-2911	256	2	1	1	NUM
fnp-2911	256	3	.	.	PUNCT
fnp-2911	256	4	m.	m.	PROPN
fnp-2911	256	5	dejesus	dejesus	PROPN
fnp-2911	256	6	-	-	PUNCT
fnp-2911	256	7	hernandez	hernandez	PROPN
fnp-2911	256	8	et	et	PROPN
fnp-2911	256	9	al	al	PROPN
fnp-2911	256	10	.	.	PROPN
fnp-2911	256	11	,	,	PUNCT
fnp-2911	256	12	expanded	expand	VERB
fnp-2911	256	13	ggggcc	ggggcc	NOUN
fnp-2911	256	14	hexanucleotide	hexanucleotide	ADJ
fnp-2911	256	15	repeat	repeat	NOUN
fnp-2911	256	16	in	in	ADP
fnp-2911	256	17	noncoding	noncoding	ADJ
fnp-2911	256	18	region	region	NOUN
fnp-2911	256	19	of	of	ADP
fnp-2911	256	20	c9orf72	c9orf72	PROPN
fnp-2911	256	21	causes	cause	VERB
fnp-2911	256	22	chromosome	chromosome	NOUN
fnp-2911	256	23	9p	9p	NUM
fnp-2911	256	24	-	-	PUNCT
fnp-2911	256	25	linked	link	VERB
fnp-2911	256	26	ftd	ftd	NOUN
fnp-2911	256	27	and	and	CCONJ
fnp-2911	256	28	als	als	PROPN
fnp-2911	256	29	.	.	PUNCT
fnp-2911	256	30	neuron	neuron	PROPN
fnp-2911	256	31	72	72	NUM
fnp-2911	256	32	,	,	PUNCT
fnp-2911	256	33	245	245	NUM
fnp-2911	256	34	(	(	PUNCT
fnp-2911	256	35	oct	oct	PROPN
fnp-2911	256	36	20	20	NUM
fnp-2911	256	37	,	,	PUNCT
fnp-2911	256	38	2011	2011	NUM
fnp-2911	256	39	)	)	PUNCT
fnp-2911	256	40	.	.	PUNCT
fnp-2911	257	1	2	2	X
fnp-2911	257	2	.	.	X
fnp-2911	257	3	a.	a.	PROPN
fnp-2911	257	4	e.	e.	PROPN
fnp-2911	257	5	renton	renton	PROPN
fnp-2911	257	6	et	et	PROPN
fnp-2911	257	7	al	al	PROPN
fnp-2911	257	8	.	.	PROPN
fnp-2911	257	9	,	,	PUNCT
fnp-2911	257	10	a	a	DET
fnp-2911	257	11	hexanucleotide	hexanucleotide	ADJ
fnp-2911	257	12	repeat	repeat	NOUN
fnp-2911	257	13	expansion	expansion	NOUN
fnp-2911	257	14	in	in	ADP
fnp-2911	257	15	c9orf72	c9orf72	PROPN
fnp-2911	257	16	is	be	AUX
fnp-2911	257	17	the	the	DET
fnp-2911	257	18	cause	cause	NOUN
fnp-2911	257	19	of	of	ADP
fnp-2911	257	20	chromosome	chromosome	NOUN
fnp-2911	257	21	9p21	9p21	NOUN
fnp-2911	257	22	-	-	PUNCT
fnp-2911	257	23	linked	link	VERB
fnp-2911	257	24	als	als	NOUN
fnp-2911	257	25	-	-	PUNCT
fnp-2911	257	26	ftd	ftd	NOUN
fnp-2911	257	27	.	.	PROPN
fnp-2911	257	28	neuron	neuron	PROPN
fnp-2911	257	29	72	72	NUM
fnp-2911	257	30	,	,	PUNCT
fnp-2911	257	31	257	257	NUM
fnp-2911	257	32	(	(	PUNCT
fnp-2911	257	33	oct	oct	PROPN
fnp-2911	257	34	20	20	NUM
fnp-2911	257	35	,	,	PUNCT
fnp-2911	257	36	2011	2011	NUM
fnp-2911	257	37	)	)	PUNCT
fnp-2911	257	38	.	.	PUNCT
fnp-2911	258	1	3	3	X
fnp-2911	258	2	.	.	X
fnp-2911	258	3	y.	y.	PROPN
fnp-2911	258	4	aoki	aoki	PROPN
fnp-2911	258	5	et	et	PROPN
fnp-2911	258	6	al	al	PROPN
fnp-2911	258	7	.	.	PROPN
fnp-2911	258	8	,	,	PUNCT
fnp-2911	258	9	c9orf72	c9orf72	PROPN
fnp-2911	258	10	and	and	CCONJ
fnp-2911	258	11	rab7l1	rab7l1	ADJ
fnp-2911	258	12	regulate	regulate	VERB
fnp-2911	258	13	vesicle	vesicle	NOUN
fnp-2911	258	14	trafficking	trafficking	NOUN
fnp-2911	258	15	in	in	ADP
fnp-2911	258	16	amyotrophic	amyotrophic	ADJ
fnp-2911	258	17	lateral	lateral	ADJ
fnp-2911	258	18	sclerosis	sclerosis	NOUN
fnp-2911	258	19	and	and	CCONJ
fnp-2911	258	20	frontotemporal	frontotemporal	ADJ
fnp-2911	258	21	dementia	dementia	NOUN
fnp-2911	258	22	.	.	PUNCT
fnp-2911	259	1	brain	brain	NOUN
fnp-2911	259	2	:	:	PUNCT
fnp-2911	259	3	a	a	DET
fnp-2911	259	4	journal	journal	NOUN
fnp-2911	259	5	of	of	ADP
fnp-2911	259	6	neurology	neurology	NOUN
fnp-2911	259	7	140	140	NUM
fnp-2911	259	8	,	,	PUNCT
fnp-2911	259	9	887	887	NUM
fnp-2911	259	10	(	(	PUNCT
fnp-2911	259	11	apr	apr	PROPN
fnp-2911	259	12	01	01	NUM
fnp-2911	259	13	,	,	PUNCT
fnp-2911	259	14	2017	2017	NUM
fnp-2911	259	15	)	)	PUNCT
fnp-2911	259	16	.	.	PUNCT
fnp-2911	260	1	4	4	X
fnp-2911	260	2	.	.	X
fnp-2911	260	3	m.	m.	NOUN
fnp-2911	260	4	a.	a.	PROPN
fnp-2911	260	5	farg	farg	PROPN
fnp-2911	260	6	et	et	PROPN
fnp-2911	260	7	al	al	PROPN
fnp-2911	260	8	.	.	PROPN
fnp-2911	260	9	,	,	PUNCT
fnp-2911	260	10	c9orf72	c9orf72	PROPN
fnp-2911	260	11	,	,	PUNCT
fnp-2911	260	12	implicated	implicate	VERB
fnp-2911	260	13	in	in	ADP
fnp-2911	260	14	amytrophic	amytrophic	ADJ
fnp-2911	260	15	lateral	lateral	ADJ
fnp-2911	260	16	sclerosis	sclerosis	NOUN
fnp-2911	260	17	and	and	CCONJ
fnp-2911	260	18	frontotemporal	frontotemporal	ADJ
fnp-2911	260	19	dementia	dementia	NOUN
fnp-2911	260	20	,	,	PUNCT
fnp-2911	260	21	regulates	regulate	VERB
fnp-2911	260	22	endosomal	endosomal	ADJ
fnp-2911	260	23	trafficking	trafficking	NOUN
fnp-2911	260	24	.	.	PUNCT
fnp-2911	261	1	hum	hum	PROPN
fnp-2911	261	2	mol	mol	ADP
fnp-2911	261	3	genet	genet	PROPN
fnp-2911	261	4	23	23	NUM
fnp-2911	261	5	,	,	PUNCT
fnp-2911	261	6	3579	3579	NUM
fnp-2911	261	7	(	(	PUNCT
fnp-2911	261	8	jul	jul	PROPN
fnp-2911	261	9	01	01	NUM
fnp-2911	261	10	,	,	PUNCT
fnp-2911	261	11	2014	2014	NUM
fnp-2911	261	12	)	)	PUNCT
fnp-2911	261	13	.	.	PUNCT
fnp-2911	262	1	5	5	X
fnp-2911	262	2	.	.	X
fnp-2911	262	3	d.	d.	PROPN
fnp-2911	262	4	zhang	zhang	PROPN
fnp-2911	262	5	,	,	PUNCT
fnp-2911	262	6	l.	l.	PROPN
fnp-2911	262	7	m.	m.	PROPN
fnp-2911	262	8	iyer	iyer	PROPN
fnp-2911	262	9	,	,	PUNCT
fnp-2911	262	10	f.	f.	PROPN
fnp-2911	262	11	he	he	PROPN
fnp-2911	262	12	,	,	PUNCT
fnp-2911	262	13	l.	l.	PROPN
fnp-2911	262	14	aravind	aravind	PROPN
fnp-2911	262	15	,	,	PUNCT
fnp-2911	262	16	discovery	discovery	NOUN
fnp-2911	262	17	of	of	ADP
fnp-2911	262	18	novel	novel	ADJ
fnp-2911	262	19	denn	denn	NOUN
fnp-2911	262	20	proteins	protein	NOUN
fnp-2911	262	21	:	:	PUNCT
fnp-2911	262	22	implications	implication	NOUN
fnp-2911	262	23	for	for	ADP
fnp-2911	262	24	the	the	DET
fnp-2911	262	25	evolution	evolution	NOUN
fnp-2911	262	26	of	of	ADP
fnp-2911	262	27	eukaryotic	eukaryotic	ADJ
fnp-2911	262	28	intracellular	intracellular	ADJ
fnp-2911	262	29	membrane	membrane	NOUN
fnp-2911	262	30	structures	structure	NOUN
fnp-2911	262	31	and	and	CCONJ
fnp-2911	262	32	human	human	ADJ
fnp-2911	262	33	disease	disease	NOUN
fnp-2911	262	34	.	.	PUNCT
fnp-2911	263	1	front	front	ADJ
fnp-2911	263	2	genet	genet	PROPN
fnp-2911	263	3	3	3	NUM
fnp-2911	263	4	,	,	PUNCT
fnp-2911	263	5	283	283	NUM
fnp-2911	263	6	(	(	PUNCT
fnp-2911	263	7	2012	2012	NUM
fnp-2911	263	8	)	)	PUNCT
fnp-2911	263	9	.	.	PUNCT
fnp-2911	264	1	6	6	X
fnp-2911	264	2	.	.	X
fnp-2911	264	3	d.	d.	PROPN
fnp-2911	264	4	tang	tang	PROPN
fnp-2911	264	5	et	et	PROPN
fnp-2911	264	6	al	al	PROPN
fnp-2911	264	7	.	.	PROPN
fnp-2911	264	8	,	,	PUNCT
fnp-2911	264	9	cryo	cryo	PROPN
fnp-2911	264	10	-	-	PUNCT
fnp-2911	264	11	em	em	PRON
fnp-2911	264	12	structure	structure	NOUN
fnp-2911	264	13	of	of	ADP
fnp-2911	264	14	c9orf72	c9orf72	PROPN
fnp-2911	264	15	-	-	PUNCT
fnp-2911	264	16	smcr8	smcr8	NOUN
fnp-2911	264	17	-	-	PUNCT
fnp-2911	264	18	wdr41	wdr41	PROPN
fnp-2911	264	19	reveals	reveal	VERB
fnp-2911	264	20	the	the	DET
fnp-2911	264	21	role	role	NOUN
fnp-2911	264	22	as	as	ADP
fnp-2911	264	23	a	a	DET
fnp-2911	264	24	gap	gap	NOUN
fnp-2911	264	25	for	for	ADP
fnp-2911	264	26	rab8a	rab8a	PROPN
fnp-2911	264	27	and	and	CCONJ
fnp-2911	264	28	rab11a	rab11a	NOUN
fnp-2911	264	29	.	.	PUNCT
fnp-2911	265	1	proc	proc	PROPN
fnp-2911	265	2	natl	natl	PROPN
fnp-2911	265	3	acad	acad	PROPN
fnp-2911	265	4	sci	sci	PROPN
fnp-2911	265	5	u	u	PROPN
fnp-2911	265	6	s	s	PROPN
fnp-2911	265	7	a	a	DET
fnp-2911	265	8	117	117	NUM
fnp-2911	265	9	,	,	PUNCT
fnp-2911	265	10	9876	9876	NUM
fnp-2911	265	11	(	(	PUNCT
fnp-2911	265	12	may	may	PROPN
fnp-2911	265	13	5	5	NUM
fnp-2911	265	14	,	,	PUNCT
fnp-2911	265	15	2020	2020	NUM
fnp-2911	265	16	)	)	PUNCT
fnp-2911	265	17	.	.	PUNCT
fnp-2911	266	1	7	7	X
fnp-2911	266	2	.	.	X
fnp-2911	266	3	c.	c.	PROPN
fnp-2911	266	4	p.	p.	PROPN
fnp-2911	266	5	cali	cali	PROPN
fnp-2911	266	6	et	et	PROPN
fnp-2911	267	1	al	al	PROPN
fnp-2911	267	2	.	.	PROPN
fnp-2911	267	3	,	,	PUNCT
fnp-2911	267	4	c9orf72	c9orf72	PROPN
fnp-2911	267	5	intermediate	intermediate	ADJ
fnp-2911	267	6	repeats	repeat	NOUN
fnp-2911	267	7	are	be	AUX
fnp-2911	267	8	associated	associate	VERB
fnp-2911	267	9	with	with	ADP
fnp-2911	267	10	corticobasal	corticobasal	NOUN
fnp-2911	267	11	degeneration	degeneration	NOUN
fnp-2911	267	12	,	,	PUNCT
fnp-2911	267	13	increased	increase	VERB
fnp-2911	267	14	c9orf72	c9orf72	ADJ
fnp-2911	267	15	expression	expression	NOUN
fnp-2911	267	16	and	and	CCONJ
fnp-2911	267	17	disruption	disruption	NOUN
fnp-2911	267	18	of	of	ADP
fnp-2911	267	19	autophagy	autophagy	NOUN
fnp-2911	267	20	.	.	PUNCT
fnp-2911	268	1	acta	acta	PROPN
fnp-2911	268	2	neuropathologica	neuropathologica	PROPN
fnp-2911	268	3	138	138	NUM
fnp-2911	268	4	,	,	PUNCT
fnp-2911	268	5	795	795	NUM
fnp-2911	268	6	(	(	PUNCT
fnp-2911	268	7	nov	nov	PROPN
fnp-2911	268	8	,	,	PUNCT
fnp-2911	268	9	2019	2019	NUM
fnp-2911	268	10	)	)	PUNCT
fnp-2911	268	11	.	.	PUNCT
fnp-2911	269	1	8	8	X
fnp-2911	269	2	.	.	X
fnp-2911	269	3	d.	d.	PROPN
fnp-2911	269	4	w.	w.	PROPN
fnp-2911	269	5	dickson	dickson	PROPN
fnp-2911	269	6	et	et	PROPN
fnp-2911	269	7	al	al	PROPN
fnp-2911	269	8	.	.	PROPN
fnp-2911	269	9	,	,	PUNCT
fnp-2911	269	10	extensive	extensive	ADJ
fnp-2911	269	11	transcriptomic	transcriptomic	ADJ
fnp-2911	269	12	study	study	NOUN
fnp-2911	269	13	emphasizes	emphasize	VERB
fnp-2911	269	14	importance	importance	NOUN
fnp-2911	269	15	of	of	ADP
fnp-2911	269	16	vesicular	vesicular	ADJ
fnp-2911	269	17	transport	transport	NOUN
fnp-2911	269	18	in	in	ADP
fnp-2911	269	19	c9orf72	c9orf72	ADJ
fnp-2911	269	20	expansion	expansion	NOUN
fnp-2911	269	21	carriers	carrier	NOUN
fnp-2911	269	22	.	.	PUNCT
fnp-2911	270	1	acta	acta	PROPN
fnp-2911	270	2	neuropathol	neuropathol	PROPN
fnp-2911	270	3	commun	commun	PROPN
fnp-2911	270	4	7	7	NUM
fnp-2911	270	5	,	,	PUNCT
fnp-2911	270	6	150	150	NUM
fnp-2911	270	7	(	(	PUNCT
fnp-2911	270	8	oct	oct	PROPN
fnp-2911	270	9	8	8	NUM
fnp-2911	270	10	,	,	PUNCT
fnp-2911	270	11	2019	2019	NUM
fnp-2911	270	12	)	)	PUNCT
fnp-2911	270	13	.	.	PUNCT
fnp-2911	271	1	9	9	X
fnp-2911	271	2	.	.	X
fnp-2911	271	3	s.	s.	PROPN
fnp-2911	271	4	c.	c.	PROPN
fnp-2911	271	5	ling	ling	PROPN
fnp-2911	271	6	,	,	PUNCT
fnp-2911	271	7	m.	m.	NOUN
fnp-2911	271	8	polymenidou	polymenidou	NOUN
fnp-2911	271	9	,	,	PUNCT
fnp-2911	271	10	d.	d.	PROPN
fnp-2911	271	11	w.	w.	PROPN
fnp-2911	271	12	cleveland	cleveland	PROPN
fnp-2911	271	13	,	,	PUNCT
fnp-2911	271	14	converging	converge	VERB
fnp-2911	271	15	mechanisms	mechanism	NOUN
fnp-2911	271	16	in	in	ADP
fnp-2911	271	17	als	al	NOUN
fnp-2911	271	18	and	and	CCONJ
fnp-2911	271	19	ftd	ftd	PROPN
fnp-2911	271	20	:	:	PUNCT
fnp-2911	271	21	disrupted	disrupt	VERB
fnp-2911	271	22	rna	rna	NOUN
fnp-2911	271	23	and	and	CCONJ
fnp-2911	271	24	protein	protein	NOUN
fnp-2911	271	25	homeostasis	homeostasis	NOUN
fnp-2911	271	26	.	.	PUNCT
fnp-2911	271	27	neuron	neuron	PROPN
fnp-2911	271	28	79	79	NUM
fnp-2911	271	29	,	,	PUNCT
fnp-2911	271	30	416	416	NUM
fnp-2911	271	31	(	(	PUNCT
fnp-2911	271	32	aug	aug	PROPN
fnp-2911	271	33	7	7	NUM
fnp-2911	271	34	,	,	PUNCT
fnp-2911	271	35	2013	2013	NUM
fnp-2911	271	36	)	)	PUNCT
fnp-2911	271	37	.	.	PUNCT
fnp-2911	272	1	10	10	NUM
fnp-2911	272	2	.	.	PUNCT
fnp-2911	273	1	j.	j.	PROPN
fnp-2911	273	2	cooper	cooper	PROPN
fnp-2911	273	3	-	-	PUNCT
fnp-2911	273	4	knock	knock	PROPN
fnp-2911	273	5	et	et	PROPN
fnp-2911	273	6	al	al	PROPN
fnp-2911	273	7	.	.	PROPN
fnp-2911	273	8	,	,	PUNCT
fnp-2911	273	9	sequestration	sequestration	NOUN
fnp-2911	273	10	of	of	ADP
fnp-2911	273	11	multiple	multiple	ADJ
fnp-2911	273	12	rna	rna	NOUN
fnp-2911	273	13	recognition	recognition	NOUN
fnp-2911	273	14	motif	motif	NOUN
fnp-2911	273	15	-	-	PUNCT
fnp-2911	273	16	containing	contain	VERB
fnp-2911	273	17	proteins	protein	NOUN
fnp-2911	273	18	by	by	ADP
fnp-2911	273	19	c9orf72	c9orf72	PROPN
fnp-2911	273	20	repeat	repeat	NOUN
fnp-2911	273	21	expansions	expansion	NOUN
fnp-2911	273	22	.	.	PUNCT
fnp-2911	274	1	brain	brain	NOUN
fnp-2911	274	2	:	:	PUNCT
fnp-2911	274	3	a	a	DET
fnp-2911	274	4	journal	journal	NOUN
fnp-2911	274	5	of	of	ADP
fnp-2911	274	6	neurology	neurology	NOUN
fnp-2911	274	7	137	137	NUM
fnp-2911	274	8	,	,	PUNCT
fnp-2911	274	9	2040	2040	NUM
fnp-2911	274	10	(	(	PUNCT
fnp-2911	274	11	jul	jul	PROPN
fnp-2911	274	12	,	,	PUNCT
fnp-2911	274	13	2014	2014	NUM
fnp-2911	274	14	)	)	PUNCT
fnp-2911	274	15	.	.	PUNCT
fnp-2911	275	1	11	11	NUM
fnp-2911	275	2	.	.	PUNCT
fnp-2911	276	1	y.	y.	PROPN
fnp-2911	276	2	b.	b.	PROPN
fnp-2911	276	3	lee	lee	PROPN
fnp-2911	276	4	et	et	PROPN
fnp-2911	276	5	al	al	PROPN
fnp-2911	276	6	.	.	PROPN
fnp-2911	276	7	,	,	PUNCT
fnp-2911	276	8	hexanucleotide	hexanucleotide	ADJ
fnp-2911	276	9	repeats	repeat	NOUN
fnp-2911	276	10	in	in	ADP
fnp-2911	276	11	als	al	NOUN
fnp-2911	276	12	/	/	SYM
fnp-2911	276	13	ftd	ftd	NOUN
fnp-2911	276	14	form	form	NOUN
fnp-2911	276	15	length	length	NOUN
fnp-2911	276	16	-	-	PUNCT
fnp-2911	276	17	dependent	dependent	ADJ
fnp-2911	276	18	rna	rna	NOUN
fnp-2911	276	19	foci	focus	NOUN
fnp-2911	276	20	,	,	PUNCT
fnp-2911	276	21	sequester	sequester	NOUN
fnp-2911	276	22	rna	rna	NOUN
fnp-2911	276	23	binding	bind	VERB
fnp-2911	276	24	proteins	protein	NOUN
fnp-2911	276	25	,	,	PUNCT
fnp-2911	276	26	and	and	CCONJ
fnp-2911	276	27	are	be	AUX
fnp-2911	276	28	neurotoxic	neurotoxic	ADJ
fnp-2911	276	29	.	.	PUNCT
fnp-2911	277	1	cell	cell	NOUN
fnp-2911	277	2	rep	rep	PROPN
fnp-2911	277	3	5	5	NUM
fnp-2911	277	4	,	,	PUNCT
fnp-2911	277	5	1178	1178	NUM
fnp-2911	277	6	(	(	PUNCT
fnp-2911	277	7	dec	dec	PROPN
fnp-2911	277	8	12	12	NUM
fnp-2911	277	9	,	,	PUNCT
fnp-2911	277	10	2013	2013	NUM
fnp-2911	277	11	)	)	PUNCT
fnp-2911	277	12	.	.	PUNCT
fnp-2911	278	1	12	12	NUM
fnp-2911	278	2	.	.	PUNCT
fnp-2911	279	1	e.	e.	PROPN
fnp-2911	279	2	g.	g.	PROPN
fnp-2911	279	3	conlon	conlon	PROPN
fnp-2911	279	4	et	et	PROPN
fnp-2911	279	5	al	al	PROPN
fnp-2911	279	6	.	.	PROPN
fnp-2911	279	7	,	,	PUNCT
fnp-2911	279	8	the	the	DET
fnp-2911	279	9	c9orf72	c9orf72	PROPN
fnp-2911	279	10	ggggcc	ggggcc	NOUN
fnp-2911	279	11	expansion	expansion	NOUN
fnp-2911	279	12	forms	form	NOUN
fnp-2911	279	13	rna	rna	VERB
fnp-2911	279	14	g	g	NOUN
fnp-2911	279	15	-	-	PUNCT
fnp-2911	279	16	quadruplex	quadruplex	NOUN
fnp-2911	279	17	inclusions	inclusion	NOUN
fnp-2911	279	18	and	and	CCONJ
fnp-2911	279	19	sequesters	sequester	VERB
fnp-2911	279	20	hnrnp	hnrnp	PROPN
fnp-2911	279	21	h	h	NOUN
fnp-2911	279	22	to	to	PART
fnp-2911	279	23	disrupt	disrupt	VERB
fnp-2911	279	24	splicing	splicing	NOUN
fnp-2911	279	25	in	in	ADP
fnp-2911	279	26	als	als	NOUN
fnp-2911	279	27	brains	brain	NOUN
fnp-2911	279	28	.	.	PUNCT
fnp-2911	280	1	elife	elife	NOUN
fnp-2911	280	2	5	5	NUM
fnp-2911	280	3	,	,	PUNCT
fnp-2911	280	4	(	(	PUNCT
fnp-2911	280	5	sep	sep	PROPN
fnp-2911	280	6	13	13	NUM
fnp-2911	280	7	,	,	PUNCT
fnp-2911	280	8	2016	2016	NUM
fnp-2911	280	9	)	)	PUNCT
fnp-2911	280	10	.	.	PUNCT
fnp-2911	281	1	13	13	NUM
fnp-2911	281	2	.	.	PUNCT
fnp-2911	282	1	j.	j.	PROPN
fnp-2911	282	2	g.	g.	PROPN
fnp-2911	282	3	o'rourke	o'rourke	PROPN
fnp-2911	282	4	et	et	PROPN
fnp-2911	282	5	al	al	PROPN
fnp-2911	282	6	.	.	PROPN
fnp-2911	282	7	,	,	PUNCT
fnp-2911	282	8	c9orf72	c9orf72	PROPN
fnp-2911	282	9	bac	bac	NOUN
fnp-2911	282	10	transgenic	transgenic	NOUN
fnp-2911	282	11	mice	mouse	NOUN
fnp-2911	282	12	display	display	VERB
fnp-2911	282	13	typical	typical	ADJ
fnp-2911	282	14	pathologic	pathologic	ADJ
fnp-2911	282	15	features	feature	NOUN
fnp-2911	282	16	of	of	ADP
fnp-2911	282	17	als	al	NOUN
fnp-2911	282	18	/	/	SYM
fnp-2911	282	19	ftd	ftd	PROPN
fnp-2911	282	20	.	.	PROPN
fnp-2911	282	21	neuron	neuron	PROPN
fnp-2911	282	22	88	88	NUM
fnp-2911	282	23	,	,	PUNCT
fnp-2911	282	24	892	892	NUM
fnp-2911	282	25	(	(	PUNCT
fnp-2911	282	26	dec	dec	PROPN
fnp-2911	282	27	02	02	NUM
fnp-2911	282	28	,	,	PUNCT
fnp-2911	282	29	2015	2015	NUM
fnp-2911	282	30	)	)	PUNCT
fnp-2911	282	31	.	.	PUNCT
fnp-2911	283	1	14	14	NUM
fnp-2911	283	2	.	.	PUNCT
fnp-2911	283	3	o.	o.	PROPN
fnp-2911	283	4	m.	m.	PROPN
fnp-2911	283	5	peters	peters	PROPN
fnp-2911	283	6	et	et	PROPN
fnp-2911	283	7	al	al	PROPN
fnp-2911	283	8	.	.	PROPN
fnp-2911	283	9	,	,	PUNCT
fnp-2911	283	10	human	human	PROPN
fnp-2911	283	11	c9orf72	c9orf72	PROPN
fnp-2911	283	12	hexanucleotide	hexanucleotide	ADJ
fnp-2911	283	13	expansion	expansion	NOUN
fnp-2911	283	14	reproduces	reproduce	VERB
fnp-2911	283	15	rna	rna	NOUN
fnp-2911	283	16	foci	focus	NOUN
fnp-2911	283	17	and	and	CCONJ
fnp-2911	283	18	dipeptide	dipeptide	NOUN
fnp-2911	283	19	repeat	repeat	NOUN
fnp-2911	283	20	proteins	protein	NOUN
fnp-2911	283	21	but	but	CCONJ
fnp-2911	283	22	not	not	PART
fnp-2911	283	23	neurodegeneration	neurodegeneration	NOUN
fnp-2911	283	24	in	in	ADP
fnp-2911	283	25	bac	bac	NOUN
fnp-2911	283	26	transgenic	transgenic	NOUN
fnp-2911	283	27	mice	mouse	NOUN
fnp-2911	283	28	.	.	PUNCT
fnp-2911	284	1	neuron	neuron	PROPN
fnp-2911	284	2	88	88	NUM
fnp-2911	284	3	,	,	PUNCT
fnp-2911	284	4	902	902	NUM
fnp-2911	284	5	(	(	PUNCT
fnp-2911	284	6	dec	dec	PROPN
fnp-2911	284	7	02	02	NUM
fnp-2911	284	8	,	,	PUNCT
fnp-2911	284	9	2015	2015	NUM
fnp-2911	284	10	)	)	PUNCT
fnp-2911	284	11	.	.	PUNCT
fnp-2911	285	1	15	15	NUM
fnp-2911	285	2	.	.	PUNCT
fnp-2911	285	3	a.	a.	NOUN
fnp-2911	285	4	jain	jain	PROPN
fnp-2911	285	5	,	,	PUNCT
fnp-2911	285	6	r.	r.	PROPN
fnp-2911	285	7	d.	d.	PROPN
fnp-2911	285	8	vale	vale	PROPN
fnp-2911	285	9	,	,	PUNCT
fnp-2911	285	10	rna	rna	NOUN
fnp-2911	285	11	phase	phase	NOUN
fnp-2911	285	12	transitions	transition	NOUN
fnp-2911	285	13	in	in	ADP
fnp-2911	285	14	repeat	repeat	NOUN
fnp-2911	285	15	expansion	expansion	NOUN
fnp-2911	285	16	disorders	disorder	NOUN
fnp-2911	285	17	.	.	PUNCT
fnp-2911	286	1	nature	nature	NOUN
fnp-2911	286	2	546	546	NUM
fnp-2911	286	3	,	,	PUNCT
fnp-2911	286	4	243	243	NUM
fnp-2911	286	5	(	(	PUNCT
fnp-2911	286	6	jun	jun	PROPN
fnp-2911	286	7	08	08	NUM
fnp-2911	286	8	,	,	PUNCT
fnp-2911	286	9	2017	2017	NUM
fnp-2911	286	10	)	)	PUNCT
fnp-2911	286	11	.	.	PUNCT
fnp-2911	287	1	16	16	NUM
fnp-2911	287	2	.	.	PUNCT
fnp-2911	288	1	h.	h.	PROPN
fnp-2911	288	2	tran	tran	PROPN
fnp-2911	288	3	et	et	PROPN
fnp-2911	288	4	al	al	PROPN
fnp-2911	288	5	.	.	PROPN
fnp-2911	288	6	,	,	PUNCT
fnp-2911	288	7	differential	differential	ADJ
fnp-2911	288	8	toxicity	toxicity	NOUN
fnp-2911	288	9	of	of	ADP
fnp-2911	288	10	nuclear	nuclear	ADJ
fnp-2911	288	11	rna	rna	NOUN
fnp-2911	288	12	foci	focus	NOUN
fnp-2911	288	13	versus	versus	ADP
fnp-2911	288	14	dipeptide	dipeptide	NOUN
fnp-2911	288	15	repeat	repeat	NOUN
fnp-2911	288	16	proteins	protein	NOUN
fnp-2911	288	17	in	in	ADP
fnp-2911	288	18	a	a	DET
fnp-2911	288	19	drosophila	drosophila	NOUN
fnp-2911	288	20	model	model	NOUN
fnp-2911	288	21	of	of	ADP
fnp-2911	288	22	c9orf72	c9orf72	PROPN
fnp-2911	288	23	ftd	ftd	PROPN
fnp-2911	288	24	/	/	SYM
fnp-2911	288	25	als	als	PROPN
fnp-2911	288	26	.	.	PUNCT
fnp-2911	288	27	neuron	neuron	PROPN
fnp-2911	288	28	87	87	NUM
fnp-2911	288	29	,	,	PUNCT
fnp-2911	288	30	1207	1207	NUM
fnp-2911	288	31	(	(	PUNCT
fnp-2911	288	32	sep	sep	PROPN
fnp-2911	288	33	23	23	NUM
fnp-2911	288	34	,	,	PUNCT
fnp-2911	288	35	2015	2015	NUM
fnp-2911	288	36	)	)	PUNCT
fnp-2911	288	37	.	.	PUNCT
fnp-2911	289	1	17	17	NUM
fnp-2911	289	2	.	.	PUNCT
fnp-2911	289	3	b.	b.	PROPN
fnp-2911	289	4	d.	d.	PROPN
fnp-2911	289	5	freibaum	freibaum	PROPN
fnp-2911	289	6	et	et	PROPN
fnp-2911	289	7	al	al	PROPN
fnp-2911	289	8	.	.	PROPN
fnp-2911	289	9	,	,	PUNCT
fnp-2911	289	10	ggggcc	ggggcc	NOUN
fnp-2911	289	11	repeat	repeat	NOUN
fnp-2911	289	12	expansion	expansion	NOUN
fnp-2911	289	13	in	in	ADP
fnp-2911	289	14	c9orf72	c9orf72	PROPN
fnp-2911	289	15	compromises	compromise	VERB
fnp-2911	289	16	nucleocytoplasmic	nucleocytoplasmic	ADJ
fnp-2911	289	17	transport	transport	NOUN
fnp-2911	289	18	.	.	PUNCT
fnp-2911	290	1	nature	nature	NOUN
fnp-2911	290	2	525	525	NUM
fnp-2911	290	3	,	,	PUNCT
fnp-2911	290	4	129	129	NUM
fnp-2911	290	5	(	(	PUNCT
fnp-2911	290	6	sep	sep	PROPN
fnp-2911	290	7	03	03	NUM
fnp-2911	290	8	,	,	PUNCT
fnp-2911	290	9	2015	2015	NUM
fnp-2911	290	10	)	)	PUNCT
fnp-2911	290	11	.	.	PUNCT
fnp-2911	291	1	18	18	NUM
fnp-2911	291	2	.	.	PUNCT
fnp-2911	291	3	a.	a.	PROPN
fnp-2911	291	4	jovicic	jovicic	PROPN
fnp-2911	291	5	et	et	PROPN
fnp-2911	291	6	al	al	PROPN
fnp-2911	291	7	.	.	PROPN
fnp-2911	291	8	,	,	PUNCT
fnp-2911	291	9	modifiers	modifier	NOUN
fnp-2911	291	10	of	of	ADP
fnp-2911	291	11	c9orf72	c9orf72	PROPN
fnp-2911	291	12	dipeptide	dipeptide	NOUN
fnp-2911	291	13	repeat	repeat	NOUN
fnp-2911	291	14	toxicity	toxicity	NOUN
fnp-2911	291	15	connect	connect	VERB
fnp-2911	291	16	nucleocytoplasmic	nucleocytoplasmic	ADJ
fnp-2911	291	17	transport	transport	NOUN
fnp-2911	291	18	defects	defect	NOUN
fnp-2911	291	19	to	to	ADP
fnp-2911	291	20	ftd	ftd	NOUN
fnp-2911	291	21	/	/	SYM
fnp-2911	291	22	als	als	NOUN
fnp-2911	291	23	.	.	PUNCT
fnp-2911	292	1	nat	nat	PROPN
fnp-2911	292	2	neurosci	neurosci	PROPN
fnp-2911	292	3	18	18	NUM
fnp-2911	292	4	,	,	PUNCT
fnp-2911	292	5	1226	1226	NUM
fnp-2911	292	6	(	(	PUNCT
fnp-2911	292	7	sep	sep	PROPN
fnp-2911	292	8	,	,	PUNCT
fnp-2911	292	9	2015	2015	NUM
fnp-2911	292	10	)	)	PUNCT
fnp-2911	292	11	.	.	PUNCT
fnp-2911	293	1	19	19	NUM
fnp-2911	293	2	.	.	PUNCT
fnp-2911	294	1	s.	s.	PROPN
fnp-2911	294	2	may	may	AUX
fnp-2911	294	3	et	et	PROPN
fnp-2911	294	4	al	al	PROPN
fnp-2911	294	5	.	.	PROPN
fnp-2911	294	6	,	,	PUNCT
fnp-2911	294	7	c9orf72	c9orf72	PROPN
fnp-2911	294	8	ftld	ftld	PROPN
fnp-2911	294	9	/	/	SYM
fnp-2911	294	10	als	al	NOUN
fnp-2911	294	11	-	-	PUNCT
fnp-2911	294	12	associated	associate	VERB
fnp-2911	294	13	gly	gly	ADJ
fnp-2911	294	14	-	-	PUNCT
fnp-2911	294	15	ala	ala	NOUN
fnp-2911	294	16	dipeptide	dipeptide	NOUN
fnp-2911	294	17	repeat	repeat	NOUN
fnp-2911	294	18	proteins	protein	NOUN
fnp-2911	294	19	cause	cause	VERB
fnp-2911	294	20	neuronal	neuronal	ADJ
fnp-2911	294	21	toxicity	toxicity	NOUN
fnp-2911	294	22	and	and	CCONJ
fnp-2911	294	23	unc119	unc119	PROPN
fnp-2911	294	24	sequestration	sequestration	NOUN
fnp-2911	294	25	.	.	PUNCT
fnp-2911	295	1	acta	acta	PROPN
fnp-2911	295	2	neuropathol	neuropathol	PROPN
fnp-2911	295	3	128	128	NUM
fnp-2911	295	4	,	,	PUNCT
fnp-2911	295	5	485	485	NUM
fnp-2911	295	6	(	(	PUNCT
fnp-2911	295	7	oct	oct	PROPN
fnp-2911	295	8	,	,	PUNCT
fnp-2911	295	9	2014	2014	NUM
fnp-2911	295	10	)	)	PUNCT
fnp-2911	295	11	.	.	PUNCT
fnp-2911	296	1	20	20	NUM
fnp-2911	296	2	.	.	PUNCT
fnp-2911	297	1	z.	z.	PROPN
fnp-2911	297	2	tao	tao	PROPN
fnp-2911	297	3	et	et	PROPN
fnp-2911	297	4	al	al	PROPN
fnp-2911	297	5	.	.	PROPN
fnp-2911	297	6	,	,	PUNCT
fnp-2911	297	7	nucleolar	nucleolar	NOUN
fnp-2911	297	8	stress	stress	NOUN
fnp-2911	297	9	and	and	CCONJ
fnp-2911	297	10	impaired	impaired	ADJ
fnp-2911	297	11	stress	stress	NOUN
fnp-2911	297	12	granule	granule	NOUN
fnp-2911	297	13	formation	formation	NOUN
fnp-2911	297	14	contribute	contribute	VERB
fnp-2911	297	15	to	to	ADP
fnp-2911	297	16	c9orf72	c9orf72	PROPN
fnp-2911	297	17	ran	run	VERB
fnp-2911	297	18	translation	translation	NOUN
fnp-2911	297	19	-	-	PUNCT
fnp-2911	297	20	induced	induce	VERB
fnp-2911	297	21	cytotoxicity	cytotoxicity	NOUN
fnp-2911	297	22	.	.	PUNCT
fnp-2911	298	1	hum	hum	PROPN
fnp-2911	298	2	mol	mol	ADP
fnp-2911	298	3	genet	genet	PROPN
fnp-2911	298	4	24	24	NUM
fnp-2911	298	5	,	,	PUNCT
fnp-2911	298	6	2426	2426	NUM
fnp-2911	298	7	(	(	PUNCT
fnp-2911	298	8	may	may	PROPN
fnp-2911	298	9	01	01	NUM
fnp-2911	298	10	,	,	PUNCT
fnp-2911	298	11	2015	2015	NUM
fnp-2911	298	12	)	)	PUNCT
fnp-2911	298	13	.	.	PUNCT
fnp-2911	299	1	21	21	NUM
fnp-2911	299	2	.	.	PUNCT
fnp-2911	299	3	x.	x.	PROPN
fnp-2911	299	4	wen	wen	PROPN
fnp-2911	299	5	et	et	PROPN
fnp-2911	299	6	al	al	PROPN
fnp-2911	299	7	.	.	PROPN
fnp-2911	299	8	,	,	PUNCT
fnp-2911	299	9	antisense	antisense	NOUN
fnp-2911	299	10	proline	proline	NOUN
fnp-2911	299	11	-	-	PUNCT
fnp-2911	299	12	arginine	arginine	NOUN
fnp-2911	299	13	ran	ran	NOUN
fnp-2911	299	14	dipeptides	dipeptide	NOUN
fnp-2911	299	15	linked	link	VERB
fnp-2911	299	16	to	to	ADP
fnp-2911	299	17	c9orf72	c9orf72	NOUN
fnp-2911	299	18	-	-	PUNCT
fnp-2911	299	19	als	als	NOUN
fnp-2911	299	20	/	/	SYM
fnp-2911	299	21	ftd	ftd	NOUN
fnp-2911	299	22	form	form	NOUN
fnp-2911	299	23	toxic	toxic	ADJ
fnp-2911	299	24	nuclear	nuclear	ADJ
fnp-2911	299	25	aggregates	aggregate	NOUN
fnp-2911	299	26	that	that	PRON
fnp-2911	299	27	initiate	initiate	VERB
fnp-2911	299	28	in	in	ADP
fnp-2911	299	29	vitro	vitro	X
fnp-2911	299	30	and	and	CCONJ
fnp-2911	299	31	in	in	ADP
fnp-2911	299	32	vivo	vivo	ADJ
fnp-2911	299	33	neuronal	neuronal	ADJ
fnp-2911	299	34	death	death	NOUN
fnp-2911	299	35	.	.	PUNCT
fnp-2911	300	1	neuron	neuron	PROPN
fnp-2911	300	2	84	84	NUM
fnp-2911	300	3	,	,	PUNCT
fnp-2911	300	4	1213	1213	NUM
fnp-2911	300	5	(	(	PUNCT
fnp-2911	300	6	dec	dec	PROPN
fnp-2911	300	7	17	17	NUM
fnp-2911	300	8	,	,	PUNCT
fnp-2911	300	9	2014	2014	NUM
fnp-2911	300	10	)	)	PUNCT
fnp-2911	300	11	.	.	PUNCT
fnp-2911	301	1	22	22	NUM
fnp-2911	301	2	.	.	PUNCT
fnp-2911	302	1	l.	l.	PROPN
fnp-2911	302	2	d.	d.	PROPN
fnp-2911	302	3	goodman	goodman	PROPN
fnp-2911	302	4	et	et	PROPN
fnp-2911	302	5	al	al	PROPN
fnp-2911	302	6	.	.	PROPN
fnp-2911	302	7	,	,	PUNCT
fnp-2911	302	8	toxic	toxic	ADJ
fnp-2911	302	9	expanded	expand	VERB
fnp-2911	302	10	ggggcc	ggggcc	NOUN
fnp-2911	302	11	repeat	repeat	NOUN
fnp-2911	302	12	transcription	transcription	NOUN
fnp-2911	302	13	is	be	AUX
fnp-2911	302	14	mediated	mediate	VERB
fnp-2911	302	15	by	by	ADP
fnp-2911	302	16	the	the	DET
fnp-2911	302	17	paf1	paf1	PROPN
fnp-2911	302	18	complex	complex	NOUN
fnp-2911	302	19	in	in	ADP
fnp-2911	302	20	c9orf72	c9orf72	PROPN
fnp-2911	302	21	-	-	PUNCT
fnp-2911	302	22	associated	associate	VERB
fnp-2911	302	23	ftd	ftd	PROPN
fnp-2911	302	24	.	.	PUNCT
fnp-2911	303	1	nature	nature	PROPN
fnp-2911	303	2	neuroscience	neuroscience	PROPN
fnp-2911	303	3	22	22	NUM
fnp-2911	303	4	,	,	PUNCT
fnp-2911	303	5	863	863	NUM
fnp-2911	303	6	(	(	PUNCT
fnp-2911	303	7	jun	jun	PROPN
fnp-2911	303	8	,	,	PUNCT
fnp-2911	303	9	2019	2019	NUM
fnp-2911	303	10	)	)	PUNCT
fnp-2911	303	11	.	.	PUNCT
fnp-2911	304	1	23	23	NUM
fnp-2911	304	2	.	.	PUNCT
fnp-2911	305	1	y.	y.	PROPN
fnp-2911	305	2	j.	j.	PROPN
fnp-2911	305	3	zhang	zhang	PROPN
fnp-2911	305	4	et	et	PROPN
fnp-2911	305	5	al	al	PROPN
fnp-2911	305	6	.	.	PROPN
fnp-2911	305	7	,	,	PUNCT
fnp-2911	305	8	heterochromatin	heterochromatin	NOUN
fnp-2911	305	9	anomalies	anomaly	NOUN
fnp-2911	305	10	and	and	CCONJ
fnp-2911	305	11	double	double	ADJ
fnp-2911	305	12	-	-	PUNCT
fnp-2911	305	13	stranded	strand	VERB
fnp-2911	305	14	rna	rna	NOUN
fnp-2911	305	15	accumulation	accumulation	NOUN
fnp-2911	305	16	underlie	underlie	ADJ
fnp-2911	305	17	c9orf72	c9orf72	PROPN
fnp-2911	305	18	poly(pr	poly(pr	PROPN
fnp-2911	305	19	)	)	PUNCT
fnp-2911	305	20	toxicity	toxicity	NOUN
fnp-2911	305	21	.	.	PUNCT
fnp-2911	306	1	science	science	NOUN
fnp-2911	306	2	363	363	NUM
fnp-2911	306	3	,	,	PUNCT
fnp-2911	306	4	(	(	PUNCT
fnp-2911	306	5	feb	feb	PROPN
fnp-2911	306	6	15	15	NUM
fnp-2911	306	7	,	,	PUNCT
fnp-2911	306	8	2019	2019	NUM
fnp-2911	306	9	)	)	PUNCT
fnp-2911	306	10	.	.	PUNCT
fnp-2911	307	1	24	24	NUM
fnp-2911	307	2	.	.	PUNCT
fnp-2911	308	1	y.	y.	PROPN
fnp-2911	308	2	j.	j.	PROPN
fnp-2911	308	3	zhang	zhang	PROPN
fnp-2911	308	4	et	et	PROPN
fnp-2911	308	5	al	al	PROPN
fnp-2911	308	6	.	.	PROPN
fnp-2911	308	7	,	,	PUNCT
fnp-2911	308	8	poly(gr	poly(gr	PROPN
fnp-2911	308	9	)	)	PUNCT
fnp-2911	308	10	impairs	impair	VERB
fnp-2911	308	11	protein	protein	NOUN
fnp-2911	308	12	translation	translation	NOUN
fnp-2911	308	13	and	and	CCONJ
fnp-2911	308	14	stress	stress	NOUN
fnp-2911	308	15	granule	granule	NOUN
fnp-2911	308	16	dynamics	dynamic	NOUN
fnp-2911	308	17	in	in	ADP
fnp-2911	308	18	c9orf72	c9orf72	NOUN
fnp-2911	308	19	-	-	PUNCT
fnp-2911	308	20	associated	associate	VERB
fnp-2911	308	21	frontotemporal	frontotemporal	ADJ
fnp-2911	308	22	dementia	dementia	NOUN
fnp-2911	308	23	and	and	CCONJ
fnp-2911	308	24	amyotrophic	amyotrophic	ADJ
fnp-2911	308	25	lateral	lateral	ADJ
fnp-2911	308	26	sclerosis	sclerosis	NOUN
fnp-2911	308	27	.	.	PUNCT
fnp-2911	309	1	nat	nat	PROPN
fnp-2911	309	2	med	me	VERB
fnp-2911	309	3	24	24	NUM
fnp-2911	309	4	,	,	PUNCT
fnp-2911	309	5	1136	1136	NUM
fnp-2911	309	6	(	(	PUNCT
fnp-2911	309	7	aug	aug	PROPN
fnp-2911	309	8	,	,	PUNCT
fnp-2911	309	9	2018	2018	NUM
fnp-2911	309	10	)	)	PUNCT
fnp-2911	309	11	.	.	PUNCT
fnp-2911	310	1	25	25	NUM
fnp-2911	310	2	.	.	PUNCT
fnp-2911	311	1	y.	y.	PROPN
fnp-2911	311	2	nihei	nihei	PROPN
fnp-2911	311	3	et	et	PROPN
fnp-2911	311	4	al	al	PROPN
fnp-2911	311	5	.	.	PROPN
fnp-2911	311	6	,	,	PUNCT
fnp-2911	311	7	poly	poly	ADJ
fnp-2911	311	8	-	-	PUNCT
fnp-2911	311	9	glycine	glycine	NOUN
fnp-2911	311	10	-	-	PUNCT
fnp-2911	311	11	alanine	alanine	NOUN
fnp-2911	311	12	exacerbates	exacerbate	VERB
fnp-2911	311	13	c9orf72	c9orf72	PROPN
fnp-2911	311	14	repeat	repeat	PROPN
fnp-2911	311	15	expansion	expansion	NOUN
fnp-2911	311	16	-	-	PUNCT
fnp-2911	311	17	mediated	mediate	VERB
fnp-2911	311	18	dna	dna	NOUN
fnp-2911	311	19	damage	damage	NOUN
fnp-2911	311	20	via	via	ADP
fnp-2911	311	21	sequestration	sequestration	NOUN
fnp-2911	311	22	of	of	ADP
fnp-2911	311	23	phosphorylated	phosphorylate	VERB
fnp-2911	311	24	atm	atm	NOUN
fnp-2911	311	25	and	and	CCONJ
fnp-2911	311	26	loss	loss	NOUN
fnp-2911	311	27	of	of	ADP
fnp-2911	311	28	nuclear	nuclear	ADJ
fnp-2911	311	29	hnrnpa3	hnrnpa3	PROPN
fnp-2911	311	30	.	.	PUNCT
fnp-2911	312	1	acta	acta	PROPN
fnp-2911	312	2	neuropathologica	neuropathologica	PROPN
fnp-2911	312	3	139	139	NUM
fnp-2911	312	4	,	,	PUNCT
fnp-2911	312	5	99	99	NUM
fnp-2911	312	6	(	(	PUNCT
fnp-2911	312	7	jan	jan	PROPN
fnp-2911	312	8	,	,	PUNCT
fnp-2911	312	9	2020	2020	NUM
fnp-2911	312	10	)	)	PUNCT
fnp-2911	312	11	.	.	PUNCT
fnp-2911	313	1	26	26	NUM
fnp-2911	313	2	.	.	PUNCT
fnp-2911	313	3	r.	r.	PROPN
fnp-2911	313	4	lopez	lopez	PROPN
fnp-2911	313	5	-	-	PUNCT
fnp-2911	313	6	gonzalez	gonzalez	PROPN
fnp-2911	313	7	et	et	PROPN
fnp-2911	313	8	al	al	PROPN
fnp-2911	313	9	.	.	PROPN
fnp-2911	313	10	,	,	PUNCT
fnp-2911	313	11	partial	partial	ADJ
fnp-2911	313	12	inhibition	inhibition	NOUN
fnp-2911	313	13	of	of	ADP
fnp-2911	313	14	the	the	DET
fnp-2911	313	15	overactivated	overactivated	ADJ
fnp-2911	313	16	ku80	ku80	PROPN
fnp-2911	313	17	-	-	PUNCT
fnp-2911	313	18	dependent	dependent	ADJ
fnp-2911	313	19	dna	dna	PROPN
fnp-2911	313	20	repair	repair	NOUN
fnp-2911	313	21	pathway	pathway	NOUN
fnp-2911	313	22	rescues	rescue	VERB
fnp-2911	313	23	neurodegeneration	neurodegeneration	NOUN
fnp-2911	313	24	in	in	ADP
fnp-2911	313	25	c9orf72	c9orf72	PROPN
fnp-2911	313	26	-	-	PUNCT
fnp-2911	313	27	als	als	NOUN
fnp-2911	313	28	/	/	SYM
fnp-2911	313	29	ftd	ftd	NOUN
fnp-2911	313	30	.	.	PUNCT
fnp-2911	314	1	proc	proc	PROPN
fnp-2911	314	2	natl	natl	PROPN
fnp-2911	314	3	acad	acad	PROPN
fnp-2911	314	4	sci	sci	PROPN
fnp-2911	314	5	u	u	PROPN
fnp-2911	314	6	s	s	PROPN
fnp-2911	314	7	a	a	DET
fnp-2911	314	8	116	116	NUM
fnp-2911	314	9	,	,	PUNCT
fnp-2911	314	10	9628	9628	NUM
fnp-2911	314	11	(	(	PUNCT
fnp-2911	314	12	may	may	PROPN
fnp-2911	314	13	7	7	NUM
fnp-2911	314	14	,	,	PUNCT
fnp-2911	314	15	2019	2019	NUM
fnp-2911	314	16	)	)	PUNCT
fnp-2911	314	17	.	.	PUNCT
fnp-2911	315	1	27	27	NUM
fnp-2911	315	2	.	.	PUNCT
fnp-2911	316	1	t.	t.	PROPN
fnp-2911	316	2	g.	g.	PROPN
fnp-2911	316	3	moens	moens	PROPN
fnp-2911	316	4	et	et	PROPN
fnp-2911	316	5	al	al	PROPN
fnp-2911	316	6	.	.	PROPN
fnp-2911	316	7	,	,	PUNCT
fnp-2911	316	8	c9orf72	c9orf72	PROPN
fnp-2911	316	9	arginine	arginine	NOUN
fnp-2911	316	10	-	-	PUNCT
fnp-2911	316	11	rich	rich	ADJ
fnp-2911	316	12	dipeptide	dipeptide	NOUN
fnp-2911	316	13	proteins	protein	NOUN
fnp-2911	316	14	interact	interact	VERB
fnp-2911	316	15	with	with	ADP
fnp-2911	316	16	ribosomal	ribosomal	NOUN
fnp-2911	316	17	proteins	protein	NOUN
fnp-2911	316	18	in	in	ADP
fnp-2911	316	19	vivo	vivo	NOUN
fnp-2911	316	20	to	to	PART
fnp-2911	316	21	induce	induce	VERB
fnp-2911	316	22	a	a	DET
fnp-2911	316	23	toxic	toxic	ADJ
fnp-2911	316	24	translational	translational	ADJ
fnp-2911	316	25	arrest	arrest	NOUN
fnp-2911	316	26	that	that	PRON
fnp-2911	316	27	is	be	AUX
fnp-2911	316	28	rescued	rescue	VERB
fnp-2911	316	29	by	by	ADP
fnp-2911	316	30	eif1a	eif1a	PROPN
fnp-2911	316	31	.	.	PUNCT
fnp-2911	317	1	acta	acta	PROPN
fnp-2911	317	2	neuropathologica	neuropathologica	PROPN
fnp-2911	317	3	137	137	NUM
fnp-2911	317	4	,	,	PUNCT
fnp-2911	317	5	487	487	NUM
fnp-2911	317	6	(	(	PUNCT
fnp-2911	317	7	mar	mar	PROPN
fnp-2911	317	8	,	,	PUNCT
fnp-2911	317	9	2019	2019	NUM
fnp-2911	317	10	)	)	PUNCT
fnp-2911	317	11	.	.	PUNCT
fnp-2911	318	1	28	28	NUM
fnp-2911	318	2	.	.	PUNCT
fnp-2911	318	3	a.	a.	PROPN
fnp-2911	318	4	jovicic	jovicic	PROPN
fnp-2911	318	5	et	et	PROPN
fnp-2911	318	6	al	al	PROPN
fnp-2911	318	7	.	.	PROPN
fnp-2911	318	8	,	,	PUNCT
fnp-2911	318	9	modifiers	modifier	NOUN
fnp-2911	318	10	of	of	ADP
fnp-2911	318	11	c9orf72	c9orf72	PROPN
fnp-2911	318	12	dipeptide	dipeptide	NOUN
fnp-2911	318	13	repeat	repeat	NOUN
fnp-2911	318	14	toxicity	toxicity	NOUN
fnp-2911	318	15	connect	connect	VERB
fnp-2911	318	16	nucleocytoplasmic	nucleocytoplasmic	ADJ
fnp-2911	318	17	transport	transport	NOUN
fnp-2911	318	18	defects	defect	NOUN
fnp-2911	318	19	to	to	ADP
fnp-2911	318	20	ftd	ftd	NOUN
fnp-2911	318	21	/	/	SYM
fnp-2911	318	22	als	als	NOUN
fnp-2911	318	23	.	.	PUNCT
fnp-2911	319	1	nature	nature	NOUN
fnp-2911	319	2	neuroscience	neuroscience	NOUN
fnp-2911	319	3	18	18	NUM
fnp-2911	319	4	,	,	PUNCT
fnp-2911	319	5	1226	1226	NUM
fnp-2911	319	6	(	(	PUNCT
fnp-2911	319	7	sep	sep	PROPN
fnp-2911	319	8	,	,	PUNCT
fnp-2911	319	9	2015	2015	NUM
fnp-2911	319	10	)	)	PUNCT
fnp-2911	319	11	.	.	PUNCT
fnp-2911	320	1	29	29	NUM
fnp-2911	320	2	.	.	PUNCT
fnp-2911	321	1	k.	k.	PROPN
fnp-2911	321	2	zhang	zhang	PROPN
fnp-2911	321	3	et	et	PROPN
fnp-2911	321	4	al	al	PROPN
fnp-2911	321	5	.	.	PROPN
fnp-2911	321	6	,	,	PUNCT
fnp-2911	321	7	the	the	DET
fnp-2911	321	8	c9orf72	c9orf72	PROPN
fnp-2911	321	9	repeat	repeat	NOUN
fnp-2911	321	10	expansion	expansion	NOUN
fnp-2911	321	11	disrupts	disrupt	VERB
fnp-2911	321	12	nucleocytoplasmic	nucleocytoplasmic	ADJ
fnp-2911	321	13	transport	transport	NOUN
fnp-2911	321	14	.	.	PUNCT
fnp-2911	322	1	nature	nature	NOUN
fnp-2911	322	2	525	525	NUM
fnp-2911	322	3	,	,	PUNCT
fnp-2911	322	4	56	56	NUM
fnp-2911	322	5	(	(	PUNCT
fnp-2911	322	6	sep	sep	PROPN
fnp-2911	322	7	3	3	NUM
fnp-2911	322	8	,	,	PUNCT
fnp-2911	322	9	2015	2015	NUM
fnp-2911	322	10	)	)	PUNCT
fnp-2911	322	11	.	.	PUNCT
fnp-2911	323	1	30	30	NUM
fnp-2911	323	2	.	.	PUNCT
fnp-2911	324	1	r.	r.	PROPN
fnp-2911	324	2	lopez	lopez	PROPN
fnp-2911	324	3	-	-	PUNCT
fnp-2911	324	4	gonzalez	gonzalez	PROPN
fnp-2911	324	5	et	et	PROPN
fnp-2911	324	6	al	al	PROPN
fnp-2911	324	7	.	.	PROPN
fnp-2911	324	8	,	,	PUNCT
fnp-2911	324	9	poly(gr	poly(gr	PROPN
fnp-2911	324	10	)	)	PUNCT
fnp-2911	324	11	in	in	ADP
fnp-2911	324	12	c9orf72	c9orf72	NOUN
fnp-2911	324	13	-	-	PUNCT
fnp-2911	324	14	related	relate	VERB
fnp-2911	324	15	als	al	NOUN
fnp-2911	324	16	/	/	SYM
fnp-2911	324	17	ftd	ftd	NOUN
fnp-2911	324	18	compromises	compromise	VERB
fnp-2911	324	19	mitochondrial	mitochondrial	ADJ
fnp-2911	324	20	function	function	NOUN
fnp-2911	324	21	and	and	CCONJ
fnp-2911	324	22	increases	increase	NOUN
fnp-2911	324	23	oxidative	oxidative	ADJ
fnp-2911	324	24	stress	stress	NOUN
fnp-2911	324	25	and	and	CCONJ
fnp-2911	324	26	dna	dna	NOUN
fnp-2911	324	27	damage	damage	NOUN
fnp-2911	324	28	in	in	ADP
fnp-2911	324	29	ipsc	ipsc	NOUN
fnp-2911	324	30	-	-	PUNCT
fnp-2911	324	31	derived	derive	VERB
fnp-2911	324	32	motor	motor	NOUN
fnp-2911	324	33	neurons	neuron	NOUN
fnp-2911	324	34	.	.	PUNCT
fnp-2911	325	1	neuron	neuron	PROPN
fnp-2911	325	2	92	92	NUM
fnp-2911	325	3	,	,	PUNCT
fnp-2911	325	4	383	383	NUM
fnp-2911	325	5	(	(	PUNCT
fnp-2911	325	6	oct	oct	PROPN
fnp-2911	325	7	19	19	NUM
fnp-2911	325	8	,	,	PUNCT
fnp-2911	325	9	2016	2016	NUM
fnp-2911	325	10	)	)	PUNCT
fnp-2911	325	11	.	.	PUNCT
fnp-2911	326	1	31	31	NUM
fnp-2911	326	2	.	.	PUNCT
fnp-2911	327	1	s.	s.	PROPN
fnp-2911	327	2	mizielinska	mizielinska	PROPN
fnp-2911	327	3	et	et	PROPN
fnp-2911	327	4	al	al	PROPN
fnp-2911	327	5	.	.	PROPN
fnp-2911	327	6	,	,	PUNCT
fnp-2911	327	7	c9orf72	c9orf72	PROPN
fnp-2911	327	8	repeat	repeat	NOUN
fnp-2911	327	9	expansions	expansion	NOUN
fnp-2911	327	10	cause	cause	VERB
fnp-2911	327	11	neurodegeneration	neurodegeneration	NOUN
fnp-2911	327	12	in	in	ADP
fnp-2911	327	13	drosophila	drosophila	PROPN
fnp-2911	327	14	through	through	ADP
fnp-2911	327	15	arginine	arginine	NOUN
fnp-2911	327	16	-	-	PUNCT
fnp-2911	327	17	rich	rich	ADJ
fnp-2911	327	18	proteins	protein	NOUN
fnp-2911	327	19	.	.	PUNCT
fnp-2911	328	1	science	science	NOUN
fnp-2911	328	2	345	345	NUM
fnp-2911	328	3	,	,	PUNCT
fnp-2911	328	4	1192	1192	NUM
fnp-2911	328	5	(	(	PUNCT
fnp-2911	328	6	sep	sep	PROPN
fnp-2911	328	7	05	05	NUM
fnp-2911	328	8	,	,	PUNCT
fnp-2911	328	9	2014	2014	NUM
fnp-2911	328	10	)	)	PUNCT
fnp-2911	328	11	.	.	PUNCT
fnp-2911	329	1	32	32	NUM
fnp-2911	329	2	.	.	PUNCT
fnp-2911	330	1	y.	y.	PROPN
fnp-2911	330	2	ohki	ohki	PROPN
fnp-2911	330	3	et	et	PROPN
fnp-2911	330	4	al	al	PROPN
fnp-2911	330	5	.	.	PROPN
fnp-2911	330	6	,	,	PUNCT
fnp-2911	330	7	glycine	glycine	NOUN
fnp-2911	330	8	-	-	PUNCT
fnp-2911	330	9	alanine	alanine	NOUN
fnp-2911	330	10	dipeptide	dipeptide	NOUN
fnp-2911	330	11	repeat	repeat	NOUN
fnp-2911	330	12	protein	protein	NOUN
fnp-2911	330	13	contributes	contribute	VERB
fnp-2911	330	14	to	to	ADP
fnp-2911	330	15	toxicity	toxicity	NOUN
fnp-2911	330	16	in	in	ADP
fnp-2911	330	17	a	a	DET
fnp-2911	330	18	zebrafish	zebrafish	ADJ
fnp-2911	330	19	model	model	NOUN
fnp-2911	330	20	of	of	ADP
fnp-2911	330	21	c9orf72	c9orf72	PROPN
fnp-2911	330	22	associated	associate	VERB
fnp-2911	330	23	neurodegeneration	neurodegeneration	NOUN
fnp-2911	330	24	.	.	PUNCT
fnp-2911	331	1	mol	mol	ADP
fnp-2911	331	2	neurodegener	neurodegener	NOUN
fnp-2911	331	3	12	12	NUM
fnp-2911	331	4	,	,	PUNCT
fnp-2911	331	5	6	6	NUM
fnp-2911	331	6	(	(	PUNCT
fnp-2911	331	7	jan	jan	PROPN
fnp-2911	331	8	14	14	NUM
fnp-2911	331	9	,	,	PUNCT
fnp-2911	331	10	2017	2017	NUM
fnp-2911	331	11	)	)	PUNCT
fnp-2911	331	12	.	.	PUNCT
fnp-2911	332	1	33	33	NUM
fnp-2911	332	2	.	.	PUNCT
fnp-2911	333	1	p.	p.	NOUN
fnp-2911	333	2	e.	e.	PROPN
fnp-2911	333	3	ash	ash	PROPN
fnp-2911	333	4	et	et	PROPN
fnp-2911	333	5	al	al	PROPN
fnp-2911	333	6	.	.	PROPN
fnp-2911	333	7	,	,	PUNCT
fnp-2911	333	8	unconventional	unconventional	ADJ
fnp-2911	333	9	translation	translation	NOUN
fnp-2911	333	10	of	of	ADP
fnp-2911	333	11	c9orf72	c9orf72	PROPN
fnp-2911	333	12	ggggcc	ggggcc	PROPN
fnp-2911	333	13	expansion	expansion	NOUN
fnp-2911	333	14	generates	generate	VERB
fnp-2911	333	15	insoluble	insoluble	ADJ
fnp-2911	333	16	polypeptides	polypeptide	NOUN
fnp-2911	333	17	specific	specific	ADJ
fnp-2911	333	18	to	to	ADP
fnp-2911	333	19	c9ftd	c9ftd	NOUN
fnp-2911	333	20	/	/	SYM
fnp-2911	333	21	als	als	PROPN
fnp-2911	333	22	.	.	PUNCT
fnp-2911	333	23	neuron	neuron	PROPN
fnp-2911	333	24	77	77	NUM
fnp-2911	333	25	,	,	PUNCT
fnp-2911	333	26	639	639	NUM
fnp-2911	333	27	(	(	PUNCT
fnp-2911	333	28	feb	feb	PROPN
fnp-2911	333	29	20	20	NUM
fnp-2911	333	30	,	,	PUNCT
fnp-2911	333	31	2013	2013	NUM
fnp-2911	333	32	)	)	PUNCT
fnp-2911	333	33	.	.	PUNCT
fnp-2911	334	1	34	34	NUM
fnp-2911	334	2	.	.	PUNCT
fnp-2911	334	3	m.	m.	PROPN
fnp-2911	334	4	dejesus	dejesus	PROPN
fnp-2911	334	5	-	-	PUNCT
fnp-2911	334	6	hernandez	hernandez	PROPN
fnp-2911	334	7	et	et	PROPN
fnp-2911	334	8	al	al	PROPN
fnp-2911	334	9	.	.	PROPN
fnp-2911	334	10	,	,	PUNCT
fnp-2911	334	11	in	in	ADP
fnp-2911	334	12	-	-	PUNCT
fnp-2911	334	13	depth	depth	NOUN
fnp-2911	334	14	clinico	clinico	NOUN
fnp-2911	334	15	-	-	PUNCT
fnp-2911	334	16	pathological	pathological	ADJ
fnp-2911	334	17	examination	examination	NOUN
fnp-2911	334	18	of	of	ADP
fnp-2911	334	19	rna	rna	NOUN
fnp-2911	334	20	foci	focus	NOUN
fnp-2911	334	21	in	in	ADP
fnp-2911	334	22	a	a	DET
fnp-2911	334	23	large	large	ADJ
fnp-2911	334	24	cohort	cohort	NOUN
fnp-2911	334	25	of	of	ADP
fnp-2911	334	26	c9orf72	c9orf72	ADJ
fnp-2911	334	27	expansion	expansion	NOUN
fnp-2911	334	28	carriers	carrier	NOUN
fnp-2911	334	29	.	.	PUNCT
fnp-2911	335	1	acta	acta	PROPN
fnp-2911	335	2	neuropathol	neuropathol	PROPN
fnp-2911	335	3	134	134	NUM
fnp-2911	335	4	,	,	PUNCT
fnp-2911	335	5	255	255	NUM
fnp-2911	335	6	(	(	PUNCT
fnp-2911	335	7	aug	aug	PROPN
fnp-2911	335	8	,	,	PUNCT
fnp-2911	335	9	2017	2017	NUM
fnp-2911	335	10	)	)	PUNCT
fnp-2911	335	11	.	.	PUNCT
fnp-2911	336	1	35	35	NUM
fnp-2911	336	2	.	.	PUNCT
fnp-2911	337	1	i.	i.	PROPN
fnp-2911	337	2	r.	r.	PROPN
fnp-2911	337	3	mackenzie	mackenzie	PROPN
fnp-2911	337	4	et	et	PROPN
fnp-2911	337	5	al	al	PROPN
fnp-2911	337	6	.	.	PROPN
fnp-2911	337	7	,	,	PUNCT
fnp-2911	337	8	quantitative	quantitative	ADJ
fnp-2911	337	9	analysis	analysis	NOUN
fnp-2911	337	10	and	and	CCONJ
fnp-2911	337	11	clinico	clinico	NOUN
fnp-2911	337	12	-	-	PUNCT
fnp-2911	337	13	pathological	pathological	ADJ
fnp-2911	337	14	correlations	correlation	NOUN
fnp-2911	337	15	of	of	ADP
fnp-2911	337	16	different	different	ADJ
fnp-2911	337	17	dipeptide	dipeptide	NOUN
fnp-2911	337	18	repeat	repeat	NOUN
fnp-2911	337	19	protein	protein	NOUN
fnp-2911	337	20	pathologies	pathology	NOUN
fnp-2911	337	21	in	in	ADP
fnp-2911	337	22	c9orf72	c9orf72	ADJ
fnp-2911	337	23	mutation	mutation	NOUN
fnp-2911	337	24	carriers	carrier	NOUN
fnp-2911	337	25	.	.	PUNCT
fnp-2911	338	1	acta	acta	PROPN
fnp-2911	338	2	neuropathol	neuropathol	PROPN
fnp-2911	338	3	130	130	NUM
fnp-2911	338	4	,	,	PUNCT
fnp-2911	338	5	845	845	NUM
fnp-2911	338	6	(	(	PUNCT
fnp-2911	338	7	dec	dec	PROPN
fnp-2911	338	8	,	,	PUNCT
fnp-2911	338	9	2015	2015	NUM
fnp-2911	338	10	)	)	PUNCT
fnp-2911	338	11	.	.	PUNCT
fnp-2911	339	1	36	36	NUM
fnp-2911	339	2	.	.	PUNCT
fnp-2911	340	1	t.	t.	PROPN
fnp-2911	340	2	g.	g.	PROPN
fnp-2911	340	3	moens	moens	PROPN
fnp-2911	340	4	et	et	PROPN
fnp-2911	340	5	al	al	PROPN
fnp-2911	340	6	.	.	PROPN
fnp-2911	340	7	,	,	PUNCT
fnp-2911	340	8	sense	sense	NOUN
fnp-2911	340	9	and	and	CCONJ
fnp-2911	340	10	antisense	antisense	NOUN
fnp-2911	340	11	rna	rna	NOUN
fnp-2911	340	12	are	be	AUX
fnp-2911	340	13	not	not	PART
fnp-2911	340	14	toxic	toxic	ADJ
fnp-2911	340	15	in	in	ADP
fnp-2911	340	16	drosophila	drosophila	NOUN
fnp-2911	340	17	models	model	NOUN
fnp-2911	340	18	of	of	ADP
fnp-2911	340	19	c9orf72	c9orf72	PROPN
fnp-2911	340	20	-	-	PUNCT
fnp-2911	340	21	associated	associate	VERB
fnp-2911	340	22	als	als	PROPN
fnp-2911	340	23	/	/	SYM
fnp-2911	340	24	ftd	ftd	PROPN
fnp-2911	340	25	.	.	PUNCT
fnp-2911	341	1	acta	acta	PROPN
fnp-2911	341	2	neuropathologica	neuropathologica	PROPN
fnp-2911	341	3	135	135	NUM
fnp-2911	341	4	,	,	PUNCT
fnp-2911	341	5	445	445	NUM
fnp-2911	341	6	(	(	PUNCT
fnp-2911	341	7	mar	mar	PROPN
fnp-2911	341	8	,	,	PUNCT
fnp-2911	341	9	2018	2018	NUM
fnp-2911	341	10	)	)	PUNCT
fnp-2911	341	11	.	.	PUNCT
fnp-2911	342	1	37	37	NUM
fnp-2911	342	2	.	.	PUNCT
fnp-2911	342	3	a.	a.	PROPN
fnp-2911	342	4	j.	j.	PROPN
fnp-2911	342	5	waite	waite	PROPN
fnp-2911	342	6	et	et	PROPN
fnp-2911	342	7	al	al	PROPN
fnp-2911	342	8	.	.	PROPN
fnp-2911	342	9	,	,	PUNCT
fnp-2911	342	10	reduced	reduce	VERB
fnp-2911	342	11	c9orf72	c9orf72	ADJ
fnp-2911	342	12	protein	protein	NOUN
fnp-2911	342	13	levels	level	NOUN
fnp-2911	342	14	in	in	ADP
fnp-2911	342	15	frontal	frontal	ADJ
fnp-2911	342	16	cortex	cortex	NOUN
fnp-2911	342	17	of	of	ADP
fnp-2911	342	18	amyotrophic	amyotrophic	ADJ
fnp-2911	342	19	lateral	lateral	ADJ
fnp-2911	342	20	sclerosis	sclerosis	NOUN
fnp-2911	342	21	and	and	CCONJ
fnp-2911	342	22	frontotemporal	frontotemporal	ADJ
fnp-2911	342	23	degeneration	degeneration	NOUN
fnp-2911	342	24	brain	brain	NOUN
fnp-2911	342	25	with	with	ADP
fnp-2911	342	26	the	the	DET
fnp-2911	342	27	c9orf72	c9orf72	PROPN
fnp-2911	342	28	hexanucleotide	hexanucleotide	ADJ
fnp-2911	342	29	repeat	repeat	NOUN
fnp-2911	342	30	expansion	expansion	NOUN
fnp-2911	342	31	.	.	PUNCT
fnp-2911	343	1	neurobiology	neurobiology	NOUN
fnp-2911	343	2	of	of	ADP
fnp-2911	343	3	aging	age	VERB
fnp-2911	343	4	35	35	NUM
fnp-2911	343	5	,	,	PUNCT
fnp-2911	343	6	1779	1779	NUM
fnp-2911	343	7	e5	e5	PROPN
fnp-2911	343	8	(	(	PUNCT
fnp-2911	343	9	jul	jul	PROPN
fnp-2911	343	10	,	,	PUNCT
fnp-2911	343	11	2014	2014	NUM
fnp-2911	343	12	)	)	PUNCT
fnp-2911	343	13	.	.	PUNCT
fnp-2911	344	1	38	38	NUM
fnp-2911	344	2	.	.	PUNCT
fnp-2911	345	1	p.	p.	NOUN
fnp-2911	345	2	frick	frick	PROPN
fnp-2911	345	3	et	et	PROPN
fnp-2911	345	4	al	al	PROPN
fnp-2911	345	5	.	.	PROPN
fnp-2911	345	6	,	,	PUNCT
fnp-2911	345	7	novel	novel	ADJ
fnp-2911	345	8	antibodies	antibody	NOUN
fnp-2911	345	9	reveal	reveal	VERB
fnp-2911	345	10	presynaptic	presynaptic	ADJ
fnp-2911	345	11	localization	localization	NOUN
fnp-2911	345	12	of	of	ADP
fnp-2911	345	13	c9orf72	c9orf72	ADJ
fnp-2911	345	14	protein	protein	NOUN
fnp-2911	345	15	and	and	CCONJ
fnp-2911	345	16	reduced	reduce	VERB
fnp-2911	345	17	protein	protein	NOUN
fnp-2911	345	18	levels	level	NOUN
fnp-2911	345	19	in	in	ADP
fnp-2911	345	20	c9orf72	c9orf72	ADJ
fnp-2911	345	21	mutation	mutation	NOUN
fnp-2911	345	22	carriers	carrier	NOUN
fnp-2911	345	23	.	.	PUNCT
fnp-2911	346	1	acta	acta	PROPN
fnp-2911	346	2	neuropathol	neuropathol	PROPN
fnp-2911	346	3	commun	commun	PROPN
fnp-2911	346	4	6	6	NUM
fnp-2911	346	5	,	,	PUNCT
fnp-2911	346	6	72	72	NUM
fnp-2911	346	7	(	(	PUNCT
fnp-2911	346	8	aug	aug	PROPN
fnp-2911	346	9	3	3	NUM
fnp-2911	346	10	,	,	PUNCT
fnp-2911	346	11	2018	2018	NUM
fnp-2911	346	12	)	)	PUNCT
fnp-2911	346	13	.	.	PUNCT
fnp-2911	347	1	39	39	NUM
fnp-2911	347	2	.	.	PUNCT
fnp-2911	347	3	a.	a.	PROPN
fnp-2911	347	4	burberry	burberry	PROPN
fnp-2911	347	5	et	et	PROPN
fnp-2911	347	6	al	al	PROPN
fnp-2911	347	7	.	.	PROPN
fnp-2911	347	8	,	,	PUNCT
fnp-2911	347	9	loss	loss	NOUN
fnp-2911	347	10	-	-	PUNCT
fnp-2911	347	11	of	of	ADP
fnp-2911	347	12	-	-	PUNCT
fnp-2911	347	13	function	function	NOUN
fnp-2911	347	14	mutations	mutation	NOUN
fnp-2911	347	15	in	in	ADP
fnp-2911	347	16	the	the	DET
fnp-2911	347	17	c9orf72	c9orf72	PROPN
fnp-2911	347	18	mouse	mouse	PROPN
fnp-2911	347	19	ortholog	ortholog	PROPN
fnp-2911	347	20	cause	cause	VERB
fnp-2911	347	21	fatal	fatal	ADJ
fnp-2911	347	22	autoimmune	autoimmune	ADJ
fnp-2911	347	23	disease	disease	NOUN
fnp-2911	347	24	.	.	PUNCT
fnp-2911	348	1	sci	sci	PROPN
fnp-2911	348	2	transl	transl	PROPN
fnp-2911	348	3	med	me	VERB
fnp-2911	348	4	8	8	NUM
fnp-2911	348	5	,	,	PUNCT
fnp-2911	348	6	347ra93	347ra93	NUM
fnp-2911	348	7	(	(	PUNCT
fnp-2911	348	8	jul	jul	PROPN
fnp-2911	348	9	13	13	NUM
fnp-2911	348	10	,	,	PUNCT
fnp-2911	348	11	2016	2016	NUM
fnp-2911	348	12	)	)	PUNCT
fnp-2911	348	13	.	.	PUNCT
fnp-2911	349	1	40	40	NUM
fnp-2911	349	2	.	.	PUNCT
fnp-2911	350	1	m.	m.	NOUN
fnp-2911	350	2	koppers	koppers	PROPN
fnp-2911	350	3	et	et	PROPN
fnp-2911	350	4	al	al	PROPN
fnp-2911	350	5	.	.	PROPN
fnp-2911	350	6	,	,	PUNCT
fnp-2911	350	7	c9orf72	c9orf72	ADJ
fnp-2911	350	8	ablation	ablation	NOUN
fnp-2911	350	9	in	in	ADP
fnp-2911	350	10	mice	mouse	NOUN
fnp-2911	350	11	does	do	AUX
fnp-2911	350	12	not	not	PART
fnp-2911	350	13	cause	cause	VERB
fnp-2911	350	14	motor	motor	NOUN
fnp-2911	350	15	neuron	neuron	NOUN
fnp-2911	350	16	degeneration	degeneration	NOUN
fnp-2911	350	17	or	or	CCONJ
fnp-2911	350	18	motor	motor	NOUN
fnp-2911	350	19	deficits	deficit	NOUN
fnp-2911	350	20	.	.	PUNCT
fnp-2911	351	1	annals	annal	NOUN
fnp-2911	351	2	of	of	ADP
fnp-2911	351	3	neurology	neurology	NOUN
fnp-2911	351	4	78	78	NUM
fnp-2911	351	5	,	,	PUNCT
fnp-2911	351	6	426	426	NUM
fnp-2911	351	7	(	(	PUNCT
fnp-2911	351	8	sep	sep	PROPN
fnp-2911	351	9	,	,	PUNCT
fnp-2911	351	10	2015	2015	NUM
fnp-2911	351	11	)	)	PUNCT
fnp-2911	351	12	.	.	PUNCT
fnp-2911	352	1	41	41	NUM
fnp-2911	352	2	.	.	PUNCT
fnp-2911	353	1	j.	j.	PROPN
fnp-2911	353	2	g.	g.	PROPN
fnp-2911	353	3	o'rourke	o'rourke	PROPN
fnp-2911	353	4	et	et	PROPN
fnp-2911	353	5	al	al	PROPN
fnp-2911	353	6	.	.	PROPN
fnp-2911	353	7	,	,	PUNCT
fnp-2911	353	8	c9orf72	c9orf72	PROPN
fnp-2911	353	9	is	be	AUX
fnp-2911	353	10	required	require	VERB
fnp-2911	353	11	for	for	ADP
fnp-2911	353	12	proper	proper	ADJ
fnp-2911	353	13	macrophage	macrophage	ADJ
fnp-2911	353	14	and	and	CCONJ
fnp-2911	353	15	microglial	microglial	ADJ
fnp-2911	353	16	function	function	NOUN
fnp-2911	353	17	in	in	ADP
fnp-2911	353	18	mice	mouse	NOUN
fnp-2911	353	19	.	.	PUNCT
fnp-2911	354	1	science	science	NOUN
fnp-2911	354	2	351	351	NUM
fnp-2911	354	3	,	,	PUNCT
fnp-2911	354	4	1324	1324	NUM
fnp-2911	354	5	(	(	PUNCT
fnp-2911	354	6	mar	mar	PROPN
fnp-2911	354	7	18	18	NUM
fnp-2911	354	8	,	,	PUNCT
fnp-2911	354	9	2016	2016	NUM
fnp-2911	354	10	)	)	PUNCT
fnp-2911	354	11	.	.	PUNCT
fnp-2911	355	1	42	42	NUM
fnp-2911	355	2	.	.	PUNCT
fnp-2911	356	1	q.	q.	PROPN
fnp-2911	356	2	zhu	zhu	PROPN
fnp-2911	356	3	et	et	PROPN
fnp-2911	356	4	al	al	PROPN
fnp-2911	356	5	.	.	PROPN
fnp-2911	356	6	,	,	PUNCT
fnp-2911	356	7	reduced	reduce	VERB
fnp-2911	356	8	c9orf72	c9orf72	PROPN
fnp-2911	356	9	function	function	NOUN
fnp-2911	356	10	exacerbates	exacerbate	VERB
fnp-2911	356	11	gain	gain	NOUN
fnp-2911	356	12	of	of	ADP
fnp-2911	356	13	toxicity	toxicity	NOUN
fnp-2911	356	14	from	from	ADP
fnp-2911	356	15	als	als	NOUN
fnp-2911	356	16	/	/	SYM
fnp-2911	356	17	ftd	ftd	NOUN
fnp-2911	356	18	-	-	PUNCT
fnp-2911	356	19	causing	cause	VERB
fnp-2911	356	20	repeat	repeat	NOUN
fnp-2911	356	21	expansion	expansion	NOUN
fnp-2911	356	22	in	in	ADP
fnp-2911	356	23	c9orf72	c9orf72	PROPN
fnp-2911	356	24	.	.	PUNCT
fnp-2911	357	1	nature	nature	NOUN
fnp-2911	357	2	neuroscience	neuroscience	NOUN
fnp-2911	357	3	23	23	NUM
fnp-2911	357	4	,	,	PUNCT
fnp-2911	357	5	615	615	NUM
fnp-2911	357	6	(	(	PUNCT
fnp-2911	357	7	may	may	AUX
fnp-2911	357	8	,	,	PUNCT
fnp-2911	357	9	2020	2020	NUM
fnp-2911	357	10	)	)	PUNCT
fnp-2911	357	11	.	.	PUNCT
fnp-2911	358	1	43	43	NUM
fnp-2911	358	2	.	.	PUNCT
fnp-2911	359	1	e.	e.	PROPN
fnp-2911	359	2	y.	y.	PROPN
fnp-2911	359	3	liu	liu	PROPN
fnp-2911	359	4	et	et	PROPN
fnp-2911	359	5	al	al	PROPN
fnp-2911	359	6	.	.	PROPN
fnp-2911	359	7	,	,	PUNCT
fnp-2911	359	8	c9orf72	c9orf72	PROPN
fnp-2911	359	9	hypermethylation	hypermethylation	NOUN
fnp-2911	359	10	protects	protect	VERB
fnp-2911	359	11	against	against	ADP
fnp-2911	359	12	repeat	repeat	NOUN
fnp-2911	359	13	expansion	expansion	NOUN
fnp-2911	359	14	-	-	PUNCT
fnp-2911	359	15	associated	associate	VERB
fnp-2911	359	16	pathology	pathology	NOUN
fnp-2911	359	17	in	in	ADP
fnp-2911	359	18	als	als	PROPN
fnp-2911	359	19	/	/	SYM
fnp-2911	359	20	ftd	ftd	PROPN
fnp-2911	359	21	.	.	PUNCT
fnp-2911	360	1	acta	acta	PROPN
fnp-2911	360	2	neuropathol	neuropathol	PROPN
fnp-2911	360	3	128	128	NUM
fnp-2911	360	4	,	,	PUNCT
fnp-2911	360	5	525	525	NUM
fnp-2911	360	6	(	(	PUNCT
fnp-2911	360	7	oct	oct	PROPN
fnp-2911	360	8	,	,	PUNCT
fnp-2911	360	9	2014	2014	NUM
fnp-2911	360	10	)	)	PUNCT
fnp-2911	360	11	.	.	PUNCT
fnp-2911	361	1	44	44	NUM
fnp-2911	361	2	.	.	PUNCT
fnp-2911	362	1	c.	c.	PROPN
fnp-2911	362	2	t.	t.	PROPN
fnp-2911	362	3	mcmillan	mcmillan	PROPN
fnp-2911	362	4	et	et	PROPN
fnp-2911	362	5	al	al	PROPN
fnp-2911	362	6	.	.	PROPN
fnp-2911	362	7	,	,	PUNCT
fnp-2911	362	8	c9orf72	c9orf72	PROPN
fnp-2911	362	9	promoter	promoter	NOUN
fnp-2911	362	10	hypermethylation	hypermethylation	NOUN
fnp-2911	362	11	is	be	AUX
fnp-2911	362	12	neuroprotective	neuroprotective	ADJ
fnp-2911	362	13	:	:	PUNCT
fnp-2911	362	14	neuroimaging	neuroimaging	NOUN
fnp-2911	362	15	and	and	CCONJ
fnp-2911	362	16	neuropathologic	neuropathologic	ADJ
fnp-2911	362	17	evidence	evidence	NOUN
fnp-2911	362	18	.	.	PUNCT
fnp-2911	363	1	neurology	neurology	NOUN
fnp-2911	363	2	84	84	NUM
fnp-2911	363	3	,	,	PUNCT
fnp-2911	363	4	1622	1622	NUM
fnp-2911	363	5	(	(	PUNCT
fnp-2911	363	6	apr	apr	PROPN
fnp-2911	363	7	21	21	NUM
fnp-2911	363	8	,	,	PUNCT
fnp-2911	363	9	2015	2015	NUM
fnp-2911	363	10	)	)	PUNCT
fnp-2911	363	11	.	.	PUNCT
fnp-2911	364	1	45	45	NUM
fnp-2911	364	2	.	.	PUNCT
fnp-2911	365	1	j.	j.	PROPN
fnp-2911	365	2	russ	russ	PROPN
fnp-2911	365	3	et	et	PROPN
fnp-2911	365	4	al	al	PROPN
fnp-2911	365	5	.	.	PROPN
fnp-2911	365	6	,	,	PUNCT
fnp-2911	365	7	hypermethylation	hypermethylation	NOUN
fnp-2911	365	8	of	of	ADP
fnp-2911	365	9	repeat	repeat	NOUN
fnp-2911	365	10	expanded	expand	VERB
fnp-2911	365	11	c9orf72	c9orf72	PROPN
fnp-2911	365	12	is	be	AUX
fnp-2911	365	13	a	a	DET
fnp-2911	365	14	clinical	clinical	ADJ
fnp-2911	365	15	and	and	CCONJ
fnp-2911	365	16	molecular	molecular	ADJ
fnp-2911	365	17	disease	disease	NOUN
fnp-2911	365	18	modifier	modifier	NOUN
fnp-2911	365	19	.	.	PUNCT
fnp-2911	366	1	acta	acta	PROPN
fnp-2911	366	2	neuropathol	neuropathol	PROPN
fnp-2911	366	3	129	129	NUM
fnp-2911	366	4	,	,	PUNCT
fnp-2911	366	5	39	39	NUM
fnp-2911	366	6	(	(	PUNCT
fnp-2911	366	7	jan	jan	PROPN
fnp-2911	366	8	,	,	PUNCT
fnp-2911	366	9	2015	2015	NUM
fnp-2911	366	10	)	)	PUNCT
fnp-2911	366	11	.	.	PUNCT
fnp-2911	367	1	46	46	NUM
fnp-2911	367	2	.	.	PUNCT
fnp-2911	368	1	k.	k.	PROPN
fnp-2911	368	2	j.	j.	PROPN
fnp-2911	368	3	karczewski	karczewski	PROPN
fnp-2911	368	4	et	et	PROPN
fnp-2911	368	5	al	al	PROPN
fnp-2911	368	6	.	.	PROPN
fnp-2911	368	7	,	,	PUNCT
fnp-2911	368	8	the	the	DET
fnp-2911	368	9	mutational	mutational	ADJ
fnp-2911	368	10	constraint	constraint	NOUN
fnp-2911	368	11	spectrum	spectrum	NOUN
fnp-2911	368	12	quantified	quantify	VERB
fnp-2911	368	13	from	from	ADP
fnp-2911	368	14	variation	variation	NOUN
fnp-2911	368	15	in	in	ADP
fnp-2911	368	16	141,456	141,456	NUM
fnp-2911	368	17	humans	human	NOUN
fnp-2911	368	18	.	.	PUNCT
fnp-2911	369	1	nature	nature	NOUN
fnp-2911	369	2	581	581	NUM
fnp-2911	369	3	,	,	PUNCT
fnp-2911	369	4	434	434	NUM
fnp-2911	369	5	(	(	PUNCT
fnp-2911	369	6	may	may	AUX
fnp-2911	369	7	,	,	PUNCT
fnp-2911	369	8	2020	2020	NUM
fnp-2911	369	9	)	)	PUNCT
fnp-2911	369	10	.	.	PUNCT
fnp-2911	370	1	47	47	NUM
fnp-2911	370	2	.	.	PUNCT
fnp-2911	370	3	r.	r.	PROPN
fnp-2911	370	4	h.	h.	PROPN
fnp-2911	370	5	batra	batra	PROPN
fnp-2911	370	6	,	,	PUNCT
fnp-2911	370	7	k.	k.	PROPN
fnp-2911	370	8	;	;	PUNCT
fnp-2911	370	9	vu	vu	PROPN
fnp-2911	370	10	,	,	PUNCT
fnp-2911	370	11	a.;rabin	a.;rabin	NOUN
fnp-2911	370	12	,	,	PUNCT
fnp-2911	370	13	s.j	s.j	PROPN
fnp-2911	370	14	.	.	PROPN
fnp-2911	370	15	;	;	PUNCT
fnp-2911	370	16	baughn	baughn	PROPN
fnp-2911	370	17	,	,	PUNCT
fnp-2911	370	18	m.w	m.w	PROPN
fnp-2911	370	19	.	.	PROPN
fnp-2911	370	20	;	;	PUNCT
fnp-2911	370	21	libby	libby	PROPN
fnp-2911	370	22	,	,	PUNCT
fnp-2911	370	23	r.t	r.t	PROPN
fnp-2911	370	24	.	.	PROPN
fnp-2911	370	25	;	;	PUNCT
fnp-2911	370	26	hoon	hoon	PROPN
fnp-2911	370	27	,	,	PUNCT
fnp-2911	370	28	s.	s.	PROPN
fnp-2911	370	29	;	;	PUNCT
fnp-2911	370	30	ravits	ravit	NOUN
fnp-2911	370	31	,	,	PUNCT
fnp-2911	370	32	j.	j.	PROPN
fnp-2911	370	33	;	;	PUNCT
fnp-2911	370	34	yeo	yeo	PROPN
fnp-2911	370	35	,	,	PUNCT
fnp-2911	370	36	g.w	g.w	PROPN
fnp-2911	370	37	.	.	PROPN
fnp-2911	370	38	,	,	PUNCT
fnp-2911	370	39	gene	gene	NOUN
fnp-2911	370	40	expression	expression	NOUN
fnp-2911	370	41	signatures	signature	NOUN
fnp-2911	370	42	of	of	ADP
fnp-2911	370	43	sporadic	sporadic	ADJ
fnp-2911	370	44	als	als	NOUN
fnp-2911	370	45	motor	motor	PROPN
fnp-2911	370	46	neuron	neuron	PROPN
fnp-2911	370	47	populations	population	NOUN
fnp-2911	370	48	.	.	PUNCT
fnp-2911	371	1	biorxiv	biorxiv	PROPN
fnp-2911	371	2	,	,	PUNCT
fnp-2911	371	3	(	(	PUNCT
fnp-2911	371	4	2016	2016	NUM
fnp-2911	371	5	)	)	PUNCT
fnp-2911	371	6	.	.	PUNCT
fnp-2911	372	1	48	48	NUM
fnp-2911	372	2	.	.	PUNCT
fnp-2911	373	1	j.	j.	PROPN
fnp-2911	373	2	cooper	cooper	PROPN
fnp-2911	373	3	-	-	PUNCT
fnp-2911	373	4	knock	knock	PROPN
fnp-2911	373	5	et	et	PROPN
fnp-2911	373	6	al	al	PROPN
fnp-2911	373	7	.	.	PROPN
fnp-2911	373	8	,	,	PUNCT
fnp-2911	373	9	c9orf72	c9orf72	PROPN
fnp-2911	373	10	ggggcc	ggggcc	NOUN
fnp-2911	373	11	expanded	expand	VERB
fnp-2911	373	12	repeats	repeat	NOUN
fnp-2911	373	13	produce	produce	VERB
fnp-2911	373	14	splicing	splicing	NOUN
fnp-2911	373	15	dysregulation	dysregulation	NOUN
fnp-2911	373	16	which	which	PRON
fnp-2911	373	17	correlates	correlate	VERB
fnp-2911	373	18	with	with	ADP
fnp-2911	373	19	disease	disease	NOUN
fnp-2911	373	20	severity	severity	NOUN
fnp-2911	373	21	in	in	ADP
fnp-2911	373	22	amyotrophic	amyotrophic	ADJ
fnp-2911	373	23	lateral	lateral	ADJ
fnp-2911	373	24	sclerosis	sclerosis	NOUN
fnp-2911	373	25	.	.	PUNCT
fnp-2911	374	1	plos	plos	PROPN
fnp-2911	374	2	one	one	NUM
fnp-2911	374	3	10	10	NUM
fnp-2911	374	4	,	,	PUNCT
fnp-2911	374	5	e0127376	e0127376	PROPN
fnp-2911	374	6	(	(	PUNCT
fnp-2911	374	7	2015	2015	NUM
fnp-2911	374	8	)	)	PUNCT
fnp-2911	374	9	.	.	PUNCT
fnp-2911	375	1	49	49	NUM
fnp-2911	375	2	.	.	PUNCT
fnp-2911	376	1	m.	m.	PROPN
fnp-2911	376	2	prudencio	prudencio	PROPN
fnp-2911	376	3	et	et	PROPN
fnp-2911	376	4	al	al	PROPN
fnp-2911	376	5	.	.	PROPN
fnp-2911	376	6	,	,	PUNCT
fnp-2911	376	7	distinct	distinct	ADJ
fnp-2911	376	8	brain	brain	NOUN
fnp-2911	376	9	transcriptome	transcriptome	ADJ
fnp-2911	376	10	profiles	profile	NOUN
fnp-2911	376	11	in	in	ADP
fnp-2911	376	12	c9orf72	c9orf72	NOUN
fnp-2911	376	13	-	-	PUNCT
fnp-2911	376	14	associated	associate	VERB
fnp-2911	376	15	and	and	CCONJ
fnp-2911	376	16	sporadic	sporadic	ADJ
fnp-2911	376	17	als	al	NOUN
fnp-2911	376	18	.	.	PUNCT
fnp-2911	377	1	nat	nat	PROPN
fnp-2911	377	2	neurosci	neurosci	PROPN
fnp-2911	377	3	18	18	NUM
fnp-2911	377	4	,	,	PUNCT
fnp-2911	377	5	1175	1175	NUM
fnp-2911	377	6	(	(	PUNCT
fnp-2911	377	7	aug	aug	PROPN
fnp-2911	377	8	,	,	PUNCT
fnp-2911	377	9	2015	2015	NUM
fnp-2911	377	10	)	)	PUNCT
fnp-2911	377	11	.	.	PUNCT
fnp-2911	378	1	50	50	NUM
fnp-2911	378	2	.	.	PUNCT
fnp-2911	379	1	f.	f.	PROPN
fnp-2911	379	2	krach	krach	PROPN
fnp-2911	379	3	et	et	PROPN
fnp-2911	379	4	al	al	PROPN
fnp-2911	379	5	.	.	PROPN
fnp-2911	379	6	,	,	PUNCT
fnp-2911	379	7	transcriptome	transcriptome	PROPN
fnp-2911	379	8	-	-	PUNCT
fnp-2911	379	9	pathology	pathology	NOUN
fnp-2911	379	10	correlation	correlation	NOUN
fnp-2911	379	11	identifies	identify	VERB
fnp-2911	379	12	interplay	interplay	NOUN
fnp-2911	379	13	between	between	ADP
fnp-2911	379	14	tdp-43	tdp-43	PROPN
fnp-2911	379	15	and	and	CCONJ
fnp-2911	379	16	the	the	DET
fnp-2911	379	17	expression	expression	NOUN
fnp-2911	379	18	of	of	ADP
fnp-2911	379	19	its	its	PRON
fnp-2911	379	20	kinase	kinase	NOUN
fnp-2911	379	21	ck1e	ck1e	PROPN
fnp-2911	379	22	in	in	ADP
fnp-2911	379	23	sporadic	sporadic	ADJ
fnp-2911	379	24	als	al	NOUN
fnp-2911	379	25	.	.	PUNCT
fnp-2911	380	1	acta	acta	PROPN
fnp-2911	380	2	neuropathologica	neuropathologica	PROPN
fnp-2911	380	3	136	136	NUM
fnp-2911	380	4	,	,	PUNCT
fnp-2911	380	5	405	405	NUM
fnp-2911	380	6	(	(	PUNCT
fnp-2911	380	7	sep	sep	PROPN
fnp-2911	380	8	,	,	PUNCT
fnp-2911	380	9	2018	2018	NUM
fnp-2911	380	10	)	)	PUNCT
fnp-2911	380	11	.	.	PUNCT
fnp-2911	381	1	51	51	NUM
fnp-2911	381	2	.	.	PUNCT
fnp-2911	382	1	s.	s.	PROPN
fnp-2911	382	2	curran	curran	PROPN
fnp-2911	382	3	,	,	PUNCT
fnp-2911	382	4	j.	j.	PROPN
fnp-2911	382	5	a.	a.	PROPN
fnp-2911	382	6	mckay	mckay	PROPN
fnp-2911	382	7	,	,	PUNCT
fnp-2911	382	8	h.	h.	PROPN
fnp-2911	382	9	l.	l.	PROPN
fnp-2911	382	10	mcleod	mcleod	PROPN
fnp-2911	382	11	,	,	PUNCT
fnp-2911	382	12	g.	g.	PROPN
fnp-2911	382	13	i.	i.	PROPN
fnp-2911	382	14	murray	murray	PROPN
fnp-2911	382	15	,	,	PUNCT
fnp-2911	382	16	laser	laser	NOUN
fnp-2911	382	17	capture	capture	NOUN
fnp-2911	382	18	microscopy	microscopy	NOUN
fnp-2911	382	19	.	.	PUNCT
fnp-2911	383	1	mol	mol	ADP
fnp-2911	383	2	pathol	pathol	NOUN
fnp-2911	383	3	53	53	NUM
fnp-2911	383	4	,	,	PUNCT
fnp-2911	383	5	64	64	NUM
fnp-2911	383	6	(	(	PUNCT
fnp-2911	383	7	apr	apr	NOUN
fnp-2911	383	8	,	,	PUNCT
fnp-2911	383	9	2000	2000	NUM
fnp-2911	383	10	)	)	PUNCT
fnp-2911	383	11	.	.	PUNCT
fnp-2911	384	1	52	52	NUM
fnp-2911	384	2	.	.	PUNCT
fnp-2911	385	1	e.	e.	PROPN
fnp-2911	385	2	y.	y.	PROPN
fnp-2911	385	3	liu	liu	PROPN
fnp-2911	385	4	et	et	PROPN
fnp-2911	385	5	al	al	PROPN
fnp-2911	385	6	.	.	PROPN
fnp-2911	385	7	,	,	PUNCT
fnp-2911	385	8	loss	loss	NOUN
fnp-2911	385	9	of	of	ADP
fnp-2911	385	10	nuclear	nuclear	ADJ
fnp-2911	385	11	tdp-43	tdp-43	PROPN
fnp-2911	385	12	is	be	AUX
fnp-2911	385	13	associated	associate	VERB
fnp-2911	385	14	with	with	ADP
fnp-2911	385	15	decondensation	decondensation	NOUN
fnp-2911	385	16	of	of	ADP
fnp-2911	385	17	line	line	NOUN
fnp-2911	385	18	retrotransposons	retrotransposon	NOUN
fnp-2911	385	19	.	.	PUNCT
fnp-2911	386	1	cell	cell	NOUN
fnp-2911	386	2	reports	report	VERB
fnp-2911	386	3	27	27	NUM
fnp-2911	386	4	,	,	PUNCT
fnp-2911	386	5	1409	1409	NUM
fnp-2911	386	6	(	(	PUNCT
fnp-2911	386	7	apr	apr	PROPN
fnp-2911	386	8	30	30	NUM
fnp-2911	386	9	,	,	PUNCT
fnp-2911	386	10	2019	2019	NUM
fnp-2911	386	11	)	)	PUNCT
fnp-2911	386	12	.	.	PUNCT
fnp-2911	387	1	53	53	NUM
fnp-2911	387	2	.	.	PUNCT
fnp-2911	387	3	j.	j.	PROPN
fnp-2911	387	4	b.	b.	PROPN
fnp-2911	387	5	toledo	toledo	PROPN
fnp-2911	387	6	et	et	PROPN
fnp-2911	387	7	al	al	PROPN
fnp-2911	387	8	.	.	PROPN
fnp-2911	387	9	,	,	PUNCT
fnp-2911	387	10	a	a	DET
fnp-2911	387	11	platform	platform	NOUN
fnp-2911	387	12	for	for	ADP
fnp-2911	387	13	discovery	discovery	NOUN
fnp-2911	387	14	:	:	PUNCT
fnp-2911	387	15	the	the	DET
fnp-2911	387	16	university	university	PROPN
fnp-2911	387	17	of	of	ADP
fnp-2911	387	18	pennsylvania	pennsylvania	PROPN
fnp-2911	387	19	integrated	integrate	VERB
fnp-2911	387	20	neurodegenerative	neurodegenerative	ADJ
fnp-2911	387	21	disease	disease	NOUN
fnp-2911	387	22	biobank	biobank	NOUN
fnp-2911	387	23	.	.	PUNCT
fnp-2911	388	1	alzheimers	alzheimers	PROPN
fnp-2911	388	2	dement	dement	PROPN
fnp-2911	388	3	10	10	NUM
fnp-2911	388	4	,	,	PUNCT
fnp-2911	388	5	477	477	NUM
fnp-2911	388	6	(	(	PUNCT
fnp-2911	388	7	jul	jul	PROPN
fnp-2911	388	8	,	,	PUNCT
fnp-2911	388	9	2014	2014	NUM
fnp-2911	388	10	)	)	PUNCT
fnp-2911	388	11	.	.	PUNCT
fnp-2911	389	1	54	54	NUM
fnp-2911	389	2	.	.	PUNCT
fnp-2911	390	1	j.	j.	PROPN
fnp-2911	390	2	r.	r.	PROPN
fnp-2911	390	3	tollervey	tollervey	VERB
fnp-2911	390	4	et	et	PROPN
fnp-2911	390	5	al	al	PROPN
fnp-2911	390	6	.	.	PROPN
fnp-2911	390	7	,	,	PUNCT
fnp-2911	390	8	characterizing	characterize	VERB
fnp-2911	390	9	the	the	DET
fnp-2911	390	10	rna	rna	NOUN
fnp-2911	390	11	targets	target	NOUN
fnp-2911	390	12	and	and	CCONJ
fnp-2911	390	13	position	position	NOUN
fnp-2911	390	14	-	-	PUNCT
fnp-2911	390	15	dependent	dependent	ADJ
fnp-2911	390	16	splicing	splicing	NOUN
fnp-2911	390	17	regulation	regulation	NOUN
fnp-2911	390	18	by	by	ADP
fnp-2911	390	19	tdp-43	tdp-43	PROPN
fnp-2911	390	20	.	.	PUNCT
fnp-2911	391	1	nat	nat	PROPN
fnp-2911	391	2	neurosci	neurosci	PROPN
fnp-2911	391	3	14	14	NUM
fnp-2911	391	4	,	,	PUNCT
fnp-2911	391	5	452	452	NUM
fnp-2911	391	6	(	(	PUNCT
fnp-2911	391	7	apr	apr	NOUN
fnp-2911	391	8	,	,	PUNCT
fnp-2911	391	9	2011	2011	NUM
fnp-2911	391	10	)	)	PUNCT
fnp-2911	391	11	.	.	PUNCT
fnp-2911	392	1	55	55	NUM
fnp-2911	392	2	.	.	PUNCT
fnp-2911	393	1	s.	s.	PROPN
fnp-2911	393	2	c.	c.	PROPN
fnp-2911	393	3	huelga	huelga	PROPN
fnp-2911	393	4	et	et	PROPN
fnp-2911	393	5	al	al	PROPN
fnp-2911	393	6	.	.	PROPN
fnp-2911	393	7	,	,	PUNCT
fnp-2911	393	8	integrative	integrative	ADJ
fnp-2911	393	9	genome	genome	NOUN
fnp-2911	393	10	-	-	PUNCT
fnp-2911	393	11	wide	wide	ADJ
fnp-2911	393	12	analysis	analysis	NOUN
fnp-2911	393	13	reveals	reveal	VERB
fnp-2911	393	14	cooperative	cooperative	ADJ
fnp-2911	393	15	regulation	regulation	NOUN
fnp-2911	393	16	of	of	ADP
fnp-2911	393	17	alternative	alternative	ADJ
fnp-2911	393	18	splicing	splicing	NOUN
fnp-2911	393	19	by	by	ADP
fnp-2911	393	20	hnrnp	hnrnp	ADJ
fnp-2911	393	21	proteins	protein	NOUN
fnp-2911	393	22	.	.	PUNCT
fnp-2911	394	1	cell	cell	NOUN
fnp-2911	394	2	rep	rep	PROPN
fnp-2911	394	3	1	1	NUM
fnp-2911	394	4	,	,	PUNCT
fnp-2911	394	5	167	167	NUM
fnp-2911	394	6	(	(	PUNCT
fnp-2911	394	7	feb	feb	PROPN
fnp-2911	394	8	23	23	NUM
fnp-2911	394	9	,	,	PUNCT
fnp-2911	394	10	2012	2012	NUM
fnp-2911	394	11	)	)	PUNCT
fnp-2911	394	12	.	.	PUNCT
fnp-2911	395	1	56	56	NUM
fnp-2911	395	2	.	.	PUNCT
fnp-2911	395	3	j.	j.	PROPN
fnp-2911	395	4	wang	wang	PROPN
fnp-2911	395	5	,	,	PUNCT
fnp-2911	395	6	d.	d.	PROPN
fnp-2911	395	7	duncan	duncan	PROPN
fnp-2911	395	8	,	,	PUNCT
fnp-2911	395	9	z.	z.	PROPN
fnp-2911	395	10	shi	shi	PROPN
fnp-2911	395	11	,	,	PUNCT
fnp-2911	395	12	b.	b.	PROPN
fnp-2911	395	13	zhang	zhang	PROPN
fnp-2911	395	14	,	,	PUNCT
fnp-2911	395	15	web	web	NOUN
fnp-2911	395	16	-	-	PUNCT
fnp-2911	395	17	based	base	VERB
fnp-2911	395	18	gene	gene	NOUN
fnp-2911	395	19	set	set	VERB
fnp-2911	395	20	analysis	analysis	NOUN
fnp-2911	395	21	toolkit	toolkit	NOUN
fnp-2911	395	22	(	(	PUNCT
fnp-2911	395	23	webgestalt	webgestalt	NOUN
fnp-2911	395	24	):	):	PUNCT
fnp-2911	395	25	update	update	NOUN
fnp-2911	395	26	2013	2013	NUM
fnp-2911	395	27	.	.	PUNCT
fnp-2911	396	1	nucleic	nucleic	ADJ
fnp-2911	396	2	acids	acid	NOUN
fnp-2911	396	3	research	research	NOUN
fnp-2911	396	4	41	41	NUM
fnp-2911	396	5	,	,	PUNCT
fnp-2911	396	6	w77	w77	NOUN
fnp-2911	396	7	(	(	PUNCT
fnp-2911	396	8	jul	jul	PROPN
fnp-2911	396	9	,	,	PUNCT
fnp-2911	396	10	2013	2013	NUM
fnp-2911	396	11	)	)	PUNCT
fnp-2911	396	12	.	.	PUNCT
fnp-2911	397	1	57	57	NUM
fnp-2911	397	2	.	.	PUNCT
fnp-2911	398	1	h.	h.	PROPN
fnp-2911	398	2	j.	j.	PROPN
fnp-2911	398	3	chen	chen	PROPN
fnp-2911	398	4	et	et	PROPN
fnp-2911	398	5	al	al	PROPN
fnp-2911	398	6	.	.	PROPN
fnp-2911	398	7	,	,	PUNCT
fnp-2911	398	8	the	the	DET
fnp-2911	398	9	heat	heat	NOUN
fnp-2911	398	10	shock	shock	NOUN
fnp-2911	398	11	response	response	NOUN
fnp-2911	398	12	plays	play	VERB
fnp-2911	398	13	an	an	DET
fnp-2911	398	14	important	important	ADJ
fnp-2911	398	15	role	role	NOUN
fnp-2911	398	16	in	in	ADP
fnp-2911	398	17	tdp-43	tdp-43	PROPN
fnp-2911	398	18	clearance	clearance	NOUN
fnp-2911	398	19	:	:	PUNCT
fnp-2911	398	20	evidence	evidence	NOUN
fnp-2911	398	21	for	for	ADP
fnp-2911	398	22	dysfunction	dysfunction	NOUN
fnp-2911	398	23	in	in	ADP
fnp-2911	398	24	amyotrophic	amyotrophic	ADJ
fnp-2911	398	25	lateral	lateral	ADJ
fnp-2911	398	26	sclerosis	sclerosis	NOUN
fnp-2911	398	27	.	.	PUNCT
fnp-2911	399	1	brain	brain	NOUN
fnp-2911	399	2	:	:	PUNCT
fnp-2911	399	3	a	a	DET
fnp-2911	399	4	journal	journal	NOUN
fnp-2911	399	5	of	of	ADP
fnp-2911	399	6	neurology	neurology	NOUN
fnp-2911	399	7	139	139	NUM
fnp-2911	399	8	,	,	PUNCT
fnp-2911	399	9	1417	1417	NUM
fnp-2911	399	10	(	(	PUNCT
fnp-2911	399	11	may	may	AUX
fnp-2911	399	12	,	,	PUNCT
fnp-2911	399	13	2016	2016	NUM
fnp-2911	399	14	)	)	PUNCT
fnp-2911	399	15	.	.	PUNCT
fnp-2911	400	1	58	58	NUM
fnp-2911	400	2	.	.	PUNCT
fnp-2911	401	1	d.	d.	PROPN
fnp-2911	401	2	chhangani	chhangani	PROPN
fnp-2911	401	3	et	et	PROPN
fnp-2911	401	4	al	al	PROPN
fnp-2911	401	5	.	.	PROPN
fnp-2911	401	6	,	,	PUNCT
fnp-2911	401	7	mahogunin	mahogunin	PROPN
fnp-2911	401	8	ring	ring	NOUN
fnp-2911	401	9	finger	finger	NOUN
fnp-2911	401	10	1	1	NUM
fnp-2911	401	11	confers	confer	NOUN
fnp-2911	401	12	cytoprotection	cytoprotection	NOUN
fnp-2911	401	13	against	against	ADP
fnp-2911	401	14	mutant	mutant	ADJ
fnp-2911	401	15	sod1	sod1	ADJ
fnp-2911	401	16	aggresomes	aggresome	NOUN
fnp-2911	401	17	and	and	CCONJ
fnp-2911	401	18	is	be	AUX
fnp-2911	401	19	defective	defective	ADJ
fnp-2911	401	20	in	in	ADP
fnp-2911	401	21	an	an	DET
fnp-2911	401	22	als	als	NOUN
fnp-2911	401	23	mouse	mouse	NOUN
fnp-2911	401	24	model	model	NOUN
fnp-2911	401	25	.	.	PUNCT
fnp-2911	402	1	neurobiol	neurobiol	PROPN
fnp-2911	402	2	dis	dis	PROPN
fnp-2911	402	3	86	86	NUM
fnp-2911	402	4	,	,	PUNCT
fnp-2911	402	5	16	16	NUM
fnp-2911	402	6	(	(	PUNCT
fnp-2911	402	7	feb	feb	PROPN
fnp-2911	402	8	,	,	PUNCT
fnp-2911	402	9	2016	2016	NUM
fnp-2911	402	10	)	)	PUNCT
fnp-2911	402	11	.	.	PUNCT
fnp-2911	403	1	59	59	NUM
fnp-2911	403	2	.	.	PUNCT
fnp-2911	403	3	a.	a.	PROPN
fnp-2911	403	4	m.	m.	PROPN
fnp-2911	403	5	ali	ali	PROPN
fnp-2911	403	6	et	et	PROPN
fnp-2911	403	7	al	al	PROPN
fnp-2911	403	8	.	.	PROPN
fnp-2911	403	9	,	,	PUNCT
fnp-2911	403	10	faap20	faap20	NOUN
fnp-2911	403	11	:	:	PUNCT
fnp-2911	403	12	a	a	DET
fnp-2911	403	13	novel	novel	ADJ
fnp-2911	403	14	ubiquitin	ubiquitin	NOUN
fnp-2911	403	15	-	-	PUNCT
fnp-2911	403	16	binding	bind	VERB
fnp-2911	403	17	fa	fa	NOUN
fnp-2911	403	18	nuclear	nuclear	ADJ
fnp-2911	403	19	core	core	NOUN
fnp-2911	403	20	-	-	PUNCT
fnp-2911	403	21	complex	complex	NOUN
fnp-2911	403	22	protein	protein	NOUN
fnp-2911	403	23	required	require	VERB
fnp-2911	403	24	for	for	ADP
fnp-2911	403	25	functional	functional	ADJ
fnp-2911	403	26	integrity	integrity	NOUN
fnp-2911	403	27	of	of	ADP
fnp-2911	403	28	the	the	DET
fnp-2911	403	29	fa	fa	PROPN
fnp-2911	403	30	-	-	PUNCT
fnp-2911	403	31	brca	brca	PROPN
fnp-2911	403	32	dna	dna	PROPN
fnp-2911	403	33	repair	repair	NOUN
fnp-2911	403	34	pathway	pathway	NOUN
fnp-2911	403	35	.	.	PUNCT
fnp-2911	404	1	blood	blood	NOUN
fnp-2911	404	2	119	119	NUM
fnp-2911	404	3	,	,	PUNCT
fnp-2911	404	4	3285	3285	NUM
fnp-2911	404	5	(	(	PUNCT
fnp-2911	404	6	apr	apr	PROPN
fnp-2911	404	7	05	05	NUM
fnp-2911	404	8	,	,	PUNCT
fnp-2911	404	9	2012	2012	NUM
fnp-2911	404	10	)	)	PUNCT
fnp-2911	404	11	.	.	PUNCT
fnp-2911	405	1	60	60	NUM
fnp-2911	405	2	.	.	PUNCT
fnp-2911	406	1	y.	y.	PROPN
fnp-2911	406	2	birger	birger	PROPN
fnp-2911	406	3	et	et	PROPN
fnp-2911	406	4	al	al	PROPN
fnp-2911	406	5	.	.	PROPN
fnp-2911	406	6	,	,	PUNCT
fnp-2911	406	7	chromosomal	chromosomal	ADJ
fnp-2911	406	8	protein	protein	NOUN
fnp-2911	406	9	hmgn1	hmgn1	NOUN
fnp-2911	406	10	enhances	enhance	VERB
fnp-2911	406	11	the	the	DET
fnp-2911	406	12	rate	rate	NOUN
fnp-2911	406	13	of	of	ADP
fnp-2911	406	14	dna	dna	PROPN
fnp-2911	406	15	repair	repair	NOUN
fnp-2911	406	16	in	in	ADP
fnp-2911	406	17	chromatin	chromatin	NOUN
fnp-2911	406	18	.	.	PUNCT
fnp-2911	407	1	the	the	DET
fnp-2911	407	2	embo	embo	PROPN
fnp-2911	407	3	journal	journal	PROPN
fnp-2911	407	4	22	22	NUM
fnp-2911	407	5	,	,	PUNCT
fnp-2911	407	6	1665	1665	NUM
fnp-2911	407	7	(	(	PUNCT
fnp-2911	407	8	apr	apr	PROPN
fnp-2911	407	9	01	01	NUM
fnp-2911	407	10	,	,	PUNCT
fnp-2911	407	11	2003	2003	NUM
fnp-2911	407	12	)	)	PUNCT
fnp-2911	407	13	.	.	PUNCT
fnp-2911	408	1	61	61	NUM
fnp-2911	408	2	.	.	PUNCT
fnp-2911	409	1	y.	y.	PROPN
fnp-2911	409	2	nomura	nomura	PROPN
fnp-2911	409	3	,	,	PUNCT
fnp-2911	409	4	n.	n.	PROPN
fnp-2911	409	5	adachi	adachi	PROPN
fnp-2911	409	6	,	,	PUNCT
fnp-2911	409	7	h.	h.	PROPN
fnp-2911	409	8	koyama	koyama	PROPN
fnp-2911	409	9	,	,	PUNCT
fnp-2911	409	10	human	human	PROPN
fnp-2911	409	11	mus81	mus81	ADJ
fnp-2911	409	12	and	and	CCONJ
fnp-2911	409	13	fancb	fancb	NOUN
fnp-2911	409	14	independently	independently	ADV
fnp-2911	409	15	contribute	contribute	VERB
fnp-2911	409	16	to	to	ADP
fnp-2911	409	17	repair	repair	NOUN
fnp-2911	409	18	of	of	ADP
fnp-2911	409	19	dna	dna	PROPN
fnp-2911	409	20	damage	damage	NOUN
fnp-2911	409	21	during	during	ADP
fnp-2911	409	22	replication	replication	NOUN
fnp-2911	409	23	.	.	PUNCT
fnp-2911	410	1	genes	gene	NOUN
fnp-2911	410	2	cells	cell	NOUN
fnp-2911	410	3	12	12	NUM
fnp-2911	410	4	,	,	PUNCT
fnp-2911	410	5	1111	1111	NUM
fnp-2911	410	6	(	(	PUNCT
fnp-2911	410	7	oct	oct	PROPN
fnp-2911	410	8	,	,	PUNCT
fnp-2911	410	9	2007	2007	NUM
fnp-2911	410	10	)	)	PUNCT
fnp-2911	410	11	.	.	PUNCT
fnp-2911	411	1	62	62	NUM
fnp-2911	411	2	.	.	PUNCT
fnp-2911	412	1	b.	b.	PROPN
fnp-2911	412	2	wang	wang	PROPN
fnp-2911	412	3	et	et	PROPN
fnp-2911	412	4	al	al	PROPN
fnp-2911	412	5	.	.	PROPN
fnp-2911	412	6	,	,	PUNCT
fnp-2911	412	7	abraxas	abraxas	PROPN
fnp-2911	412	8	and	and	CCONJ
fnp-2911	412	9	rap80	rap80	NOUN
fnp-2911	412	10	form	form	VERB
fnp-2911	412	11	a	a	DET
fnp-2911	412	12	brca1	brca1	NOUN
fnp-2911	412	13	protein	protein	NOUN
fnp-2911	412	14	complex	complex	NOUN
fnp-2911	412	15	required	require	VERB
fnp-2911	412	16	for	for	ADP
fnp-2911	412	17	the	the	DET
fnp-2911	412	18	dna	dna	PROPN
fnp-2911	412	19	damage	damage	NOUN
fnp-2911	412	20	response	response	NOUN
fnp-2911	412	21	.	.	PUNCT
fnp-2911	413	1	science	science	NOUN
fnp-2911	413	2	316	316	NUM
fnp-2911	413	3	,	,	PUNCT
fnp-2911	413	4	1194	1194	NUM
fnp-2911	413	5	(	(	PUNCT
fnp-2911	413	6	may	may	PROPN
fnp-2911	413	7	25	25	NUM
fnp-2911	413	8	,	,	PUNCT
fnp-2911	413	9	2007	2007	NUM
fnp-2911	413	10	)	)	PUNCT
fnp-2911	413	11	.	.	PUNCT
fnp-2911	414	1	63	63	NUM
fnp-2911	414	2	.	.	PUNCT
fnp-2911	414	3	l.	l.	PROPN
fnp-2911	414	4	castellini	castellini	PROPN
fnp-2911	414	5	et	et	PROPN
fnp-2911	414	6	al	al	PROPN
fnp-2911	414	7	.	.	PROPN
fnp-2911	414	8	,	,	PUNCT
fnp-2911	414	9	kdm4b	kdm4b	NOUN
fnp-2911	414	10	/	/	SYM
fnp-2911	414	11	jmjd2b	jmjd2b	PROPN
fnp-2911	414	12	is	be	AUX
fnp-2911	414	13	a	a	DET
fnp-2911	414	14	p53	p53	NOUN
fnp-2911	414	15	target	target	NOUN
fnp-2911	414	16	gene	gene	NOUN
fnp-2911	414	17	that	that	PRON
fnp-2911	414	18	modulates	modulate	VERB
fnp-2911	414	19	the	the	DET
fnp-2911	414	20	amplitude	amplitude	NOUN
fnp-2911	414	21	of	of	ADP
fnp-2911	414	22	p53	p53	NOUN
fnp-2911	414	23	response	response	NOUN
fnp-2911	414	24	after	after	ADP
fnp-2911	414	25	dna	dna	PROPN
fnp-2911	414	26	damage	damage	NOUN
fnp-2911	414	27	.	.	PUNCT
fnp-2911	415	1	nucleic	nucleic	ADJ
fnp-2911	415	2	acids	acid	NOUN
fnp-2911	415	3	research	research	NOUN
fnp-2911	415	4	45	45	NUM
fnp-2911	415	5	,	,	PUNCT
fnp-2911	415	6	3674	3674	NUM
fnp-2911	415	7	(	(	PUNCT
fnp-2911	415	8	apr	apr	NOUN
fnp-2911	415	9	20	20	NUM
fnp-2911	415	10	,	,	PUNCT
fnp-2911	415	11	2017	2017	NUM
fnp-2911	415	12	)	)	PUNCT
fnp-2911	415	13	.	.	PUNCT
fnp-2911	416	1	64	64	NUM
fnp-2911	416	2	.	.	PUNCT
fnp-2911	417	1	l.	l.	PROPN
fnp-2911	417	2	miccoli	miccoli	PROPN
fnp-2911	417	3	et	et	PROPN
fnp-2911	417	4	al	al	PROPN
fnp-2911	417	5	.	.	PROPN
fnp-2911	417	6	,	,	PUNCT
fnp-2911	417	7	selective	selective	ADJ
fnp-2911	417	8	interactions	interaction	NOUN
fnp-2911	417	9	of	of	ADP
fnp-2911	417	10	human	human	ADJ
fnp-2911	417	11	kin17	kin17	PROPN
fnp-2911	417	12	and	and	CCONJ
fnp-2911	417	13	rpa	rpa	PROPN
fnp-2911	417	14	proteins	protein	NOUN
fnp-2911	417	15	with	with	ADP
fnp-2911	417	16	chromatin	chromatin	NOUN
fnp-2911	417	17	and	and	CCONJ
fnp-2911	417	18	the	the	DET
fnp-2911	417	19	nuclear	nuclear	ADJ
fnp-2911	417	20	matrix	matrix	NOUN
fnp-2911	417	21	in	in	ADP
fnp-2911	417	22	a	a	DET
fnp-2911	417	23	dna	dna	NOUN
fnp-2911	417	24	damageand	damageand	PROPN
fnp-2911	417	25	cell	cell	NOUN
fnp-2911	417	26	cycle	cycle	NOUN
fnp-2911	417	27	-	-	PUNCT
fnp-2911	417	28	regulated	regulate	VERB
fnp-2911	417	29	manner	manner	NOUN
fnp-2911	417	30	.	.	PUNCT
fnp-2911	418	1	nucleic	nucleic	ADJ
fnp-2911	418	2	acids	acid	NOUN
fnp-2911	418	3	research	research	NOUN
fnp-2911	418	4	31	31	NUM
fnp-2911	418	5	,	,	PUNCT
fnp-2911	418	6	4162	4162	NUM
fnp-2911	418	7	(	(	PUNCT
fnp-2911	418	8	jul	jul	PROPN
fnp-2911	418	9	15	15	NUM
fnp-2911	418	10	,	,	PUNCT
fnp-2911	418	11	2003	2003	NUM
fnp-2911	418	12	)	)	PUNCT
fnp-2911	418	13	.	.	PUNCT
fnp-2911	419	1	65	65	NUM
fnp-2911	419	2	.	.	PUNCT
fnp-2911	419	3	l.	l.	PROPN
fnp-2911	419	4	c.	c.	PROPN
fnp-2911	419	5	young	young	PROPN
fnp-2911	419	6	,	,	PUNCT
fnp-2911	419	7	d.	d.	PROPN
fnp-2911	419	8	w.	w.	PROPN
fnp-2911	419	9	mcdonald	mcdonald	PROPN
fnp-2911	419	10	,	,	PUNCT
fnp-2911	419	11	m.	m.	NOUN
fnp-2911	419	12	j.	j.	PROPN
fnp-2911	419	13	hendzel	hendzel	PROPN
fnp-2911	419	14	,	,	PUNCT
fnp-2911	419	15	kdm4b	kdm4b	PROPN
fnp-2911	419	16	histone	histone	NOUN
fnp-2911	419	17	demethylase	demethylase	NOUN
fnp-2911	419	18	is	be	AUX
fnp-2911	419	19	a	a	DET
fnp-2911	419	20	dna	dna	PROPN
fnp-2911	419	21	damage	damage	NOUN
fnp-2911	419	22	response	response	NOUN
fnp-2911	419	23	protein	protein	NOUN
fnp-2911	419	24	and	and	CCONJ
fnp-2911	419	25	confers	confer	NOUN
fnp-2911	419	26	a	a	DET
fnp-2911	419	27	survival	survival	NOUN
fnp-2911	419	28	advantage	advantage	NOUN
fnp-2911	419	29	following	follow	VERB
fnp-2911	419	30	gamma	gamma	NOUN
fnp-2911	419	31	-	-	PUNCT
fnp-2911	419	32	irradiation	irradiation	NOUN
fnp-2911	419	33	.	.	PUNCT
fnp-2911	420	1	the	the	DET
fnp-2911	420	2	journal	journal	NOUN
fnp-2911	420	3	of	of	ADP
fnp-2911	420	4	biological	biological	ADJ
fnp-2911	420	5	chemistry	chemistry	NOUN
fnp-2911	420	6	288	288	NUM
fnp-2911	420	7	,	,	PUNCT
fnp-2911	420	8	21376	21376	NUM
fnp-2911	420	9	(	(	PUNCT
fnp-2911	420	10	jul	jul	PROPN
fnp-2911	420	11	19	19	NUM
fnp-2911	420	12	,	,	PUNCT
fnp-2911	420	13	2013	2013	NUM
fnp-2911	420	14	)	)	PUNCT
fnp-2911	420	15	.	.	PUNCT
fnp-2911	421	1	66	66	NUM
fnp-2911	421	2	.	.	PUNCT
fnp-2911	422	1	b.	b.	PROPN
fnp-2911	422	2	chen	chen	PROPN
fnp-2911	422	3	,	,	PUNCT
fnp-2911	422	4	j.	j.	PROPN
fnp-2911	422	5	yun	yun	PROPN
fnp-2911	422	6	,	,	PUNCT
fnp-2911	422	7	m.	m.	NOUN
fnp-2911	422	8	s.	s.	PROPN
fnp-2911	422	9	kim	kim	PROPN
fnp-2911	422	10	,	,	PUNCT
fnp-2911	422	11	j.	j.	PROPN
fnp-2911	422	12	t.	t.	PROPN
fnp-2911	422	13	mendell	mendell	PROPN
fnp-2911	422	14	,	,	PUNCT
fnp-2911	422	15	y.	y.	PROPN
fnp-2911	422	16	xie	xie	PROPN
fnp-2911	422	17	,	,	PUNCT
fnp-2911	422	18	pipe	pipe	NOUN
fnp-2911	422	19	-	-	PUNCT
fnp-2911	422	20	clip	clip	NOUN
fnp-2911	422	21	:	:	PUNCT
fnp-2911	422	22	a	a	DET
fnp-2911	422	23	comprehensive	comprehensive	ADJ
fnp-2911	422	24	online	online	ADJ
fnp-2911	422	25	tool	tool	NOUN
fnp-2911	422	26	for	for	ADP
fnp-2911	422	27	clip	clip	NOUN
fnp-2911	422	28	-	-	PUNCT
fnp-2911	422	29	seq	seq	NOUN
fnp-2911	422	30	data	datum	NOUN
fnp-2911	422	31	analysis	analysis	NOUN
fnp-2911	422	32	.	.	PUNCT
fnp-2911	423	1	genome	genome	NOUN
fnp-2911	423	2	biol	biol	NOUN
fnp-2911	423	3	15	15	NUM
fnp-2911	423	4	,	,	PUNCT
fnp-2911	423	5	r18	r18	PROPN
fnp-2911	423	6	(	(	PUNCT
fnp-2911	423	7	jan	jan	PROPN
fnp-2911	423	8	22	22	NUM
fnp-2911	423	9	,	,	PUNCT
fnp-2911	423	10	2014	2014	NUM
fnp-2911	423	11	)	)	PUNCT
fnp-2911	423	12	.	.	PUNCT
fnp-2911	424	1	67	67	NUM
fnp-2911	424	2	.	.	PUNCT
fnp-2911	425	1	e.	e.	PROPN
fnp-2911	425	2	b.	b.	PROPN
fnp-2911	425	3	lee	lee	PROPN
fnp-2911	425	4	et	et	PROPN
fnp-2911	425	5	al	al	PROPN
fnp-2911	425	6	.	.	PROPN
fnp-2911	425	7	,	,	PUNCT
fnp-2911	425	8	expansion	expansion	NOUN
fnp-2911	425	9	of	of	ADP
fnp-2911	425	10	the	the	DET
fnp-2911	425	11	classification	classification	NOUN
fnp-2911	425	12	of	of	ADP
fnp-2911	425	13	ftld	ftld	ADJ
fnp-2911	425	14	-	-	PUNCT
fnp-2911	425	15	tdp	tdp	NOUN
fnp-2911	425	16	:	:	PUNCT
fnp-2911	425	17	distinct	distinct	ADJ
fnp-2911	425	18	pathology	pathology	NOUN
fnp-2911	425	19	associated	associate	VERB
fnp-2911	425	20	with	with	ADP
fnp-2911	425	21	rapidly	rapidly	ADV
fnp-2911	425	22	progressive	progressive	ADJ
fnp-2911	425	23	frontotemporal	frontotemporal	ADJ
fnp-2911	425	24	degeneration	degeneration	NOUN
fnp-2911	425	25	.	.	PUNCT
fnp-2911	426	1	acta	acta	PROPN
fnp-2911	426	2	neuropathologica	neuropathologica	PROPN
fnp-2911	426	3	134	134	NUM
fnp-2911	426	4	,	,	PUNCT
fnp-2911	426	5	65	65	NUM
fnp-2911	426	6	(	(	PUNCT
fnp-2911	426	7	jul	jul	PROPN
fnp-2911	426	8	,	,	PUNCT
fnp-2911	426	9	2017	2017	NUM
fnp-2911	426	10	)	)	PUNCT
fnp-2911	426	11	.	.	PUNCT
fnp-2911	427	1	68	68	NUM
fnp-2911	427	2	.	.	PUNCT
fnp-2911	427	3	m.	m.	NOUN
fnp-2911	427	4	a.	a.	NOUN
fnp-2911	427	5	farg	farg	PROPN
fnp-2911	427	6	,	,	PUNCT
fnp-2911	427	7	a.	a.	NOUN
fnp-2911	427	8	konopka	konopka	PROPN
fnp-2911	427	9	,	,	PUNCT
fnp-2911	427	10	k.	k.	PROPN
fnp-2911	427	11	ying	ying	PROPN
fnp-2911	427	12	soo	soo	PROPN
fnp-2911	427	13	,	,	PUNCT
fnp-2911	427	14	d.	d.	PROPN
fnp-2911	427	15	ito	ito	PROPN
fnp-2911	427	16	,	,	PUNCT
fnp-2911	427	17	j.	j.	PROPN
fnp-2911	427	18	d.	d.	PROPN
fnp-2911	427	19	atkin	atkin	PROPN
fnp-2911	427	20	,	,	PUNCT
fnp-2911	427	21	the	the	DET
fnp-2911	427	22	dna	dna	PROPN
fnp-2911	427	23	damage	damage	NOUN
fnp-2911	427	24	response	response	NOUN
fnp-2911	427	25	(	(	PUNCT
fnp-2911	427	26	ddr	ddr	NOUN
fnp-2911	427	27	)	)	PUNCT
fnp-2911	427	28	is	be	AUX
fnp-2911	427	29	induced	induce	VERB
fnp-2911	427	30	by	by	ADP
fnp-2911	427	31	the	the	DET
fnp-2911	427	32	c9orf72	c9orf72	PROPN
fnp-2911	427	33	repeat	repeat	NOUN
fnp-2911	427	34	expansion	expansion	NOUN
fnp-2911	427	35	in	in	ADP
fnp-2911	427	36	amyotrophic	amyotrophic	ADJ
fnp-2911	427	37	lateral	lateral	ADJ
fnp-2911	427	38	sclerosis	sclerosis	NOUN
fnp-2911	427	39	.	.	PUNCT
fnp-2911	428	1	hum	hum	PROPN
fnp-2911	428	2	mol	mol	ADP
fnp-2911	428	3	genet	genet	PROPN
fnp-2911	428	4	,	,	PUNCT
fnp-2911	428	5	(	(	PUNCT
fnp-2911	428	6	may	may	PROPN
fnp-2911	428	7	08	08	NUM
fnp-2911	428	8	,	,	PUNCT
fnp-2911	428	9	2017	2017	NUM
fnp-2911	428	10	)	)	PUNCT
fnp-2911	428	11	.	.	PUNCT
fnp-2911	429	1	69	69	NUM
fnp-2911	429	2	.	.	PUNCT
fnp-2911	429	3	a.	a.	NOUN
fnp-2911	429	4	lopez	lopez	PROPN
fnp-2911	429	5	castel	castel	PROPN
fnp-2911	429	6	,	,	PUNCT
fnp-2911	429	7	j.	j.	PROPN
fnp-2911	429	8	d.	d.	PROPN
fnp-2911	429	9	cleary	cleary	PROPN
fnp-2911	429	10	,	,	PUNCT
fnp-2911	429	11	c.	c.	PROPN
fnp-2911	429	12	e.	e.	PROPN
fnp-2911	429	13	pearson	pearson	PROPN
fnp-2911	429	14	,	,	PUNCT
fnp-2911	429	15	repeat	repeat	VERB
fnp-2911	429	16	instability	instability	NOUN
fnp-2911	429	17	as	as	ADP
fnp-2911	429	18	the	the	DET
fnp-2911	429	19	basis	basis	NOUN
fnp-2911	429	20	for	for	ADP
fnp-2911	429	21	human	human	ADJ
fnp-2911	429	22	diseases	disease	NOUN
fnp-2911	429	23	and	and	CCONJ
fnp-2911	429	24	as	as	ADP
fnp-2911	429	25	a	a	DET
fnp-2911	429	26	potential	potential	ADJ
fnp-2911	429	27	target	target	NOUN
fnp-2911	429	28	for	for	ADP
fnp-2911	429	29	therapy	therapy	NOUN
fnp-2911	429	30	.	.	PUNCT
fnp-2911	430	1	nat	nat	PROPN
fnp-2911	430	2	rev	rev	VERB
fnp-2911	430	3	mol	mol	ADP
fnp-2911	430	4	cell	cell	NOUN
fnp-2911	430	5	biol	biol	NOUN
fnp-2911	430	6	11	11	NUM
fnp-2911	430	7	,	,	PUNCT
fnp-2911	430	8	165	165	NUM
fnp-2911	430	9	(	(	PUNCT
fnp-2911	430	10	mar	mar	PROPN
fnp-2911	430	11	,	,	PUNCT
fnp-2911	430	12	2010	2010	NUM
fnp-2911	430	13	)	)	PUNCT
fnp-2911	430	14	.	.	PUNCT
fnp-2911	431	1	70	70	NUM
fnp-2911	431	2	.	.	PUNCT
fnp-2911	432	1	p.	p.	NOUN
fnp-2911	432	2	m.	m.	PROPN
fnp-2911	432	3	douglas	douglas	PROPN
fnp-2911	432	4	,	,	PUNCT
fnp-2911	432	5	a.	a.	PROPN
fnp-2911	432	6	dillin	dillin	PROPN
fnp-2911	432	7	,	,	PUNCT
fnp-2911	432	8	protein	protein	NOUN
fnp-2911	432	9	homeostasis	homeostasis	NOUN
fnp-2911	432	10	and	and	CCONJ
fnp-2911	432	11	aging	aging	NOUN
fnp-2911	432	12	in	in	ADP
fnp-2911	432	13	neurodegeneration	neurodegeneration	NOUN
fnp-2911	432	14	.	.	PUNCT
fnp-2911	433	1	j	j	PROPN
fnp-2911	433	2	cell	cell	NOUN
fnp-2911	433	3	biol	biol	NOUN
fnp-2911	433	4	190	190	NUM
fnp-2911	433	5	,	,	PUNCT
fnp-2911	433	6	719	719	NUM
fnp-2911	433	7	(	(	PUNCT
fnp-2911	433	8	sep	sep	PROPN
fnp-2911	433	9	06	06	NUM
fnp-2911	433	10	,	,	PUNCT
fnp-2911	433	11	2010	2010	NUM
fnp-2911	433	12	)	)	PUNCT
fnp-2911	433	13	.	.	PUNCT
fnp-2911	434	1	71	71	NUM
fnp-2911	434	2	.	.	PUNCT
fnp-2911	434	3	o.	o.	PROPN
fnp-2911	434	4	d.	d.	PROPN
fnp-2911	434	5	king	king	PROPN
fnp-2911	434	6	,	,	PUNCT
fnp-2911	434	7	a.	a.	PROPN
fnp-2911	434	8	d.	d.	PROPN
fnp-2911	434	9	gitler	gitler	PROPN
fnp-2911	434	10	,	,	PUNCT
fnp-2911	434	11	j.	j.	PROPN
fnp-2911	434	12	shorter	shorter	PROPN
fnp-2911	434	13	,	,	PUNCT
fnp-2911	434	14	the	the	DET
fnp-2911	434	15	tip	tip	NOUN
fnp-2911	434	16	of	of	ADP
fnp-2911	434	17	the	the	DET
fnp-2911	434	18	iceberg	iceberg	NOUN
fnp-2911	434	19	:	:	PUNCT
fnp-2911	434	20	rna	rna	NOUN
fnp-2911	434	21	-	-	PUNCT
fnp-2911	434	22	binding	bind	VERB
fnp-2911	434	23	proteins	protein	NOUN
fnp-2911	434	24	with	with	ADP
fnp-2911	434	25	prion	prion	NOUN
fnp-2911	434	26	-	-	PUNCT
fnp-2911	434	27	like	like	ADJ
fnp-2911	434	28	domains	domain	NOUN
fnp-2911	434	29	in	in	ADP
fnp-2911	434	30	neurodegenerative	neurodegenerative	ADJ
fnp-2911	434	31	disease	disease	NOUN
fnp-2911	434	32	.	.	PUNCT
fnp-2911	435	1	brain	brain	NOUN
fnp-2911	435	2	res	re	NOUN
fnp-2911	435	3	1462	1462	NUM
fnp-2911	435	4	,	,	PUNCT
fnp-2911	435	5	61	61	NUM
fnp-2911	435	6	(	(	PUNCT
fnp-2911	435	7	jun	jun	PROPN
fnp-2911	435	8	26	26	NUM
fnp-2911	435	9	,	,	PUNCT
fnp-2911	435	10	2012	2012	NUM
fnp-2911	435	11	)	)	PUNCT
fnp-2911	435	12	.	.	PUNCT
fnp-2911	436	1	72	72	NUM
fnp-2911	436	2	.	.	PUNCT
fnp-2911	436	3	m.	m.	PROPN
fnp-2911	436	4	e.	e.	PROPN
fnp-2911	436	5	jackrel	jackrel	PROPN
fnp-2911	436	6	et	et	PROPN
fnp-2911	436	7	al	al	PROPN
fnp-2911	436	8	.	.	PROPN
fnp-2911	436	9	,	,	PUNCT
fnp-2911	436	10	potentiated	potentiate	VERB
fnp-2911	436	11	hsp104	hsp104	PROPN
fnp-2911	436	12	variants	variant	NOUN
fnp-2911	436	13	antagonize	antagonize	VERB
fnp-2911	436	14	diverse	diverse	ADJ
fnp-2911	436	15	proteotoxic	proteotoxic	ADJ
fnp-2911	436	16	misfolding	misfolde	VERB
fnp-2911	436	17	events	event	NOUN
fnp-2911	436	18	.	.	PUNCT
fnp-2911	437	1	cell	cell	NOUN
fnp-2911	437	2	156	156	NUM
fnp-2911	437	3	,	,	PUNCT
fnp-2911	437	4	170	170	NUM
fnp-2911	437	5	(	(	PUNCT
fnp-2911	437	6	jan	jan	PROPN
fnp-2911	437	7	16	16	NUM
fnp-2911	437	8	,	,	PUNCT
fnp-2911	437	9	2014	2014	NUM
fnp-2911	437	10	)	)	PUNCT
fnp-2911	437	11	.	.	PUNCT
fnp-2911	438	1	73	73	NUM
fnp-2911	438	2	.	.	PUNCT
fnp-2911	439	1	p.	p.	NOUN
fnp-2911	439	2	y.	y.	PROPN
fnp-2911	439	3	lin	lin	PROPN
fnp-2911	439	4	et	et	PROPN
fnp-2911	439	5	al	al	PROPN
fnp-2911	439	6	.	.	PROPN
fnp-2911	439	7	,	,	PUNCT
fnp-2911	439	8	heat	heat	NOUN
fnp-2911	439	9	shock	shock	NOUN
fnp-2911	439	10	factor	factor	NOUN
fnp-2911	439	11	1	1	NUM
fnp-2911	439	12	over	over	ADP
fnp-2911	439	13	-	-	PUNCT
fnp-2911	439	14	expression	expression	NOUN
fnp-2911	439	15	protects	protect	NOUN
fnp-2911	439	16	against	against	ADP
fnp-2911	439	17	exposure	exposure	NOUN
fnp-2911	439	18	of	of	ADP
fnp-2911	439	19	hydrophobic	hydrophobic	NOUN
fnp-2911	439	20	residues	residue	NOUN
fnp-2911	439	21	on	on	ADP
fnp-2911	439	22	mutant	mutant	ADJ
fnp-2911	439	23	sod1	sod1	NOUN
fnp-2911	439	24	and	and	CCONJ
fnp-2911	439	25	early	early	ADJ
fnp-2911	439	26	mortality	mortality	NOUN
fnp-2911	439	27	in	in	ADP
fnp-2911	439	28	a	a	DET
fnp-2911	439	29	mouse	mouse	NOUN
fnp-2911	439	30	model	model	NOUN
fnp-2911	439	31	of	of	ADP
fnp-2911	439	32	amyotrophic	amyotrophic	ADJ
fnp-2911	439	33	lateral	lateral	ADJ
fnp-2911	439	34	sclerosis	sclerosis	NOUN
fnp-2911	439	35	.	.	PUNCT
fnp-2911	440	1	mol	mol	ADP
fnp-2911	440	2	neurodegener	neurodegener	NOUN
fnp-2911	440	3	8	8	NUM
fnp-2911	440	4	,	,	PUNCT
fnp-2911	440	5	43	43	NUM
fnp-2911	440	6	(	(	PUNCT
fnp-2911	440	7	nov	nov	PROPN
fnp-2911	440	8	21	21	NUM
fnp-2911	440	9	,	,	PUNCT
fnp-2911	440	10	2013	2013	NUM
fnp-2911	440	11	)	)	PUNCT
fnp-2911	440	12	.	.	PUNCT
fnp-2911	441	1	copyright	copyright	NOUN
fnp-2911	441	2	:	:	PUNCT
fnp-2911	441	3	©	©	PROPN
fnp-2911	441	4	2020	2020	NUM
fnp-2911	441	5	the	the	DET
fnp-2911	441	6	author(s	author(s	NOUN
fnp-2911	441	7	)	)	PUNCT
fnp-2911	441	8	.	.	PUNCT
fnp-2911	442	1	this	this	PRON
fnp-2911	442	2	is	be	AUX
fnp-2911	442	3	an	an	DET
fnp-2911	442	4	open	open	ADJ
fnp-2911	442	5	access	access	NOUN
fnp-2911	442	6	article	article	NOUN
fnp-2911	442	7	distributed	distribute	VERB
fnp-2911	442	8	under	under	ADP
fnp-2911	442	9	the	the	DET
fnp-2911	442	10	terms	term	NOUN
fnp-2911	442	11	of	of	ADP
fnp-2911	442	12	the	the	DET
fnp-2911	442	13	creative	creative	ADJ
fnp-2911	442	14	commons	common	NOUN
fnp-2911	442	15	attribution	attribution	NOUN
fnp-2911	442	16	4.0	4.0	NUM
fnp-2911	442	17	international	international	ADJ
fnp-2911	442	18	license	license	NOUN
fnp-2911	442	19	(	(	PUNCT
fnp-2911	442	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-2911	442	21	)	)	PUNCT
fnp-2911	442	22	,	,	PUNCT
fnp-2911	442	23	which	which	PRON
fnp-2911	442	24	permits	permit	VERB
fnp-2911	442	25	unrestricted	unrestricted	ADJ
fnp-2911	442	26	use	use	NOUN
fnp-2911	442	27	,	,	PUNCT
fnp-2911	442	28	distribution	distribution	NOUN
fnp-2911	442	29	,	,	PUNCT
fnp-2911	442	30	and	and	CCONJ
fnp-2911	442	31	reproduction	reproduction	NOUN
fnp-2911	442	32	in	in	ADP
fnp-2911	442	33	any	any	DET
fnp-2911	442	34	medium	medium	NOUN
fnp-2911	442	35	,	,	PUNCT
fnp-2911	442	36	provided	provide	VERB
fnp-2911	442	37	the	the	DET
fnp-2911	442	38	original	original	ADJ
fnp-2911	442	39	author	author	NOUN
fnp-2911	442	40	and	and	CCONJ
fnp-2911	442	41	source	source	NOUN
fnp-2911	442	42	are	be	AUX
fnp-2911	442	43	credited	credit	VERB
fnp-2911	442	44	,	,	PUNCT
fnp-2911	442	45	a	a	DET
fnp-2911	442	46	link	link	NOUN
fnp-2911	442	47	to	to	ADP
fnp-2911	442	48	the	the	DET
fnp-2911	442	49	creative	creative	ADJ
fnp-2911	442	50	commons	common	NOUN
fnp-2911	442	51	license	license	NOUN
fnp-2911	442	52	is	be	AUX
fnp-2911	442	53	provided	provide	VERB
fnp-2911	442	54	,	,	PUNCT
fnp-2911	442	55	and	and	CCONJ
fnp-2911	442	56	any	any	DET
fnp-2911	442	57	changes	change	NOUN
fnp-2911	442	58	are	be	AUX
fnp-2911	442	59	indicated	indicate	VERB
fnp-2911	442	60	.	.	PUNCT
fnp-2911	443	1	the	the	DET
fnp-2911	443	2	creative	creative	ADJ
fnp-2911	443	3	commons	common	NOUN
fnp-2911	443	4	public	public	ADJ
fnp-2911	443	5	domain	domain	NOUN
fnp-2911	443	6	dedication	dedication	NOUN
fnp-2911	443	7	waiver	waiver	NOUN
fnp-2911	443	8	(	(	PUNCT
fnp-2911	443	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-2911	443	10	)	)	PUNCT
fnp-2911	443	11	applies	apply	VERB
fnp-2911	443	12	to	to	ADP
fnp-2911	443	13	the	the	DET
fnp-2911	443	14	data	datum	NOUN
fnp-2911	443	15	made	make	VERB
fnp-2911	443	16	available	available	ADJ
fnp-2911	443	17	in	in	ADP
fnp-2911	443	18	this	this	DET
fnp-2911	443	19	article	article	NOUN
fnp-2911	443	20	,	,	PUNCT
fnp-2911	443	21	unless	unless	SCONJ
fnp-2911	443	22	otherwise	otherwise	ADV
fnp-2911	443	23	stated	state	VERB
fnp-2911	443	24	.	.	PUNCT