id	sid	tid	token	lemma	pos
fnp-3049	1	1	inhibiting	inhibit	VERB
fnp-3049	1	2	the	the	DET
fnp-3049	1	3	mitochondrial	mitochondrial	ADJ
fnp-3049	1	4	pyruvate	pyruvate	NOUN
fnp-3049	1	5	carrier	carrier	NOUN
fnp-3049	1	6	does	do	AUX
fnp-3049	1	7	not	not	PART
fnp-3049	1	8	ameliorate	ameliorate	VERB
fnp-3049	1	9	synucleinopathy	synucleinopathy	NOUN
fnp-3049	1	10	in	in	ADP
fnp-3049	1	11	the	the	DET
fnp-3049	1	12	absence	absence	NOUN
fnp-3049	1	13	of	of	ADP
fnp-3049	1	14	inflammation	inflammation	NOUN
fnp-3049	1	15	or	or	CCONJ
fnp-3049	1	16	metabolic	metabolic	NOUN
fnp-3049	1	17	deficits	deficit	NOUN
fnp-3049	1	18	feel	feel	VERB
fnp-3049	1	19	free	free	ADJ
fnp-3049	1	20	to	to	PART
fnp-3049	1	21	add	add	VERB
fnp-3049	1	22	comments	comment	NOUN
fnp-3049	1	23	by	by	ADP
fnp-3049	1	24	clicking	click	VERB
fnp-3049	1	25	these	these	DET
fnp-3049	1	26	icons	icon	NOUN
fnp-3049	1	27	on	on	ADP
fnp-3049	1	28	the	the	DET
fnp-3049	1	29	sidebar	sidebar	NOUN
fnp-3049	1	30	free	free	ADJ
fnp-3049	1	31	neuropathology	neuropathology	NOUN
fnp-3049	1	32	1:33	1:33	NUM
fnp-3049	1	33	(	(	PUNCT
fnp-3049	1	34	2020	2020	NUM
fnp-3049	1	35	)	)	PUNCT
fnp-3049	1	36	original	original	ADJ
fnp-3049	1	37	paper	paper	NOUN
fnp-3049	1	38	inhibiting	inhibit	VERB
fnp-3049	1	39	the	the	DET
fnp-3049	1	40	mitochondrial	mitochondrial	ADJ
fnp-3049	1	41	pyruvate	pyruvate	NOUN
fnp-3049	1	42	carrier	carrier	NOUN
fnp-3049	1	43	does	do	AUX
fnp-3049	1	44	not	not	PART
fnp-3049	1	45	ameliorate	ameliorate	VERB
fnp-3049	1	46	synucleinopathy	synucleinopathy	NOUN
fnp-3049	1	47	in	in	ADP
fnp-3049	1	48	the	the	DET
fnp-3049	1	49	absence	absence	NOUN
fnp-3049	1	50	of	of	ADP
fnp-3049	1	51	inflammation	inflammation	NOUN
fnp-3049	1	52	or	or	CCONJ
fnp-3049	1	53	metabolic	metabolic	NOUN
fnp-3049	1	54	deficits	deficit	NOUN
fnp-3049	1	55	wouter	wouter	PROPN
fnp-3049	1	56	peelaerts1,2	peelaerts1,2	PROPN
fnp-3049	1	57	*	*	PROPN
fnp-3049	1	58	,	,	PUNCT
fnp-3049	1	59	liza	liza	PROPN
fnp-3049	1	60	bergkvist1	bergkvist1	PROPN
fnp-3049	1	61	,	,	PUNCT
fnp-3049	1	62	#	#	NOUN
fnp-3049	1	63	*	*	NOUN
fnp-3049	1	64	,	,	PUNCT
fnp-3049	1	65	sonia	sonia	PROPN
fnp-3049	1	66	george1	george1	PROPN
fnp-3049	1	67	,	,	PUNCT
fnp-3049	1	68	michaela	michaela	PROPN
fnp-3049	1	69	johnson1	johnson1	PROPN
fnp-3049	1	70	,	,	PUNCT
fnp-3049	1	71	lindsay	lindsay	PROPN
fnp-3049	1	72	meyerdirk1	meyerdirk1	PROPN
fnp-3049	1	73	,	,	PUNCT
fnp-3049	1	74	emily	emily	PROPN
fnp-3049	1	75	schulz1	schulz1	PROPN
fnp-3049	1	76	,	,	PUNCT
fnp-3049	1	77	jennifer	jennifer	PROPN
fnp-3049	1	78	a.	a.	PROPN
fnp-3049	1	79	steiner1	steiner1	PROPN
fnp-3049	1	80	,	,	PUNCT
fnp-3049	1	81	zachary	zachary	PROPN
fnp-3049	1	82	madaj3	madaj3	PROPN
fnp-3049	1	83	,	,	PUNCT
fnp-3049	1	84	jiyan	jiyan	PROPN
fnp-3049	1	85	ma1	ma1	PROPN
fnp-3049	1	86	,	,	PUNCT
fnp-3049	1	87	katelyn	katelyn	PROPN
fnp-3049	1	88	becker1	becker1	PROPN
fnp-3049	1	89	,	,	PUNCT
fnp-3049	1	90	k.	k.	PROPN
fnp-3049	1	91	peter	peter	PROPN
fnp-3049	1	92	r.	r.	PROPN
fnp-3049	1	93	nilsson4	nilsson4	PROPN
fnp-3049	1	94	,	,	PUNCT
fnp-3049	1	95	jerry	jerry	PROPN
fnp-3049	1	96	r.	r.	PROPN
fnp-3049	1	97	colca5	colca5	PROPN
fnp-3049	1	98	and	and	CCONJ
fnp-3049	1	99	patrik	patrik	PROPN
fnp-3049	1	100	brundin1	brundin1	PROPN
fnp-3049	1	101	1	1	NUM
fnp-3049	1	102	center	center	NOUN
fnp-3049	1	103	for	for	ADP
fnp-3049	1	104	neurodegenerative	neurodegenerative	ADJ
fnp-3049	1	105	science	science	NOUN
fnp-3049	1	106	,	,	PUNCT
fnp-3049	1	107	van	van	PROPN
fnp-3049	1	108	andel	andel	PROPN
fnp-3049	1	109	institute	institute	PROPN
fnp-3049	1	110	,	,	PUNCT
fnp-3049	1	111	grand	grand	PROPN
fnp-3049	1	112	rapids	rapids	PROPN
fnp-3049	1	113	,	,	PUNCT
fnp-3049	1	114	mi	mi	PROPN
fnp-3049	1	115	,	,	PUNCT
fnp-3049	1	116	usa	usa	PROPN
fnp-3049	1	117	.	.	PROPN
fnp-3049	1	118	2	2	NUM
fnp-3049	1	119	ku	ku	PROPN
fnp-3049	1	120	leuven	leuven	PROPN
fnp-3049	1	121	,	,	PUNCT
fnp-3049	1	122	laboratory	laboratory	NOUN
fnp-3049	1	123	for	for	ADP
fnp-3049	1	124	neurobiology	neurobiology	NOUN
fnp-3049	1	125	and	and	CCONJ
fnp-3049	1	126	gene	gene	NOUN
fnp-3049	1	127	therapy	therapy	NOUN
fnp-3049	1	128	,	,	PUNCT
fnp-3049	1	129	dept	dept	NOUN
fnp-3049	1	130	.	.	PROPN
fnp-3049	1	131	of	of	ADP
fnp-3049	1	132	neurosciences	neuroscience	NOUN
fnp-3049	1	133	,	,	PUNCT
fnp-3049	1	134	leuven	leuven	PROPN
fnp-3049	1	135	,	,	PUNCT
fnp-3049	1	136	belgium	belgium	NOUN
fnp-3049	1	137	.	.	PROPN
fnp-3049	2	1	3	3	NUM
fnp-3049	2	2	bioinformatics	bioinformatic	NOUN
fnp-3049	2	3	and	and	CCONJ
fnp-3049	2	4	biostatistics	biostatistic	NOUN
fnp-3049	2	5	core	core	NOUN
fnp-3049	2	6	,	,	PUNCT
fnp-3049	2	7	van	van	PROPN
fnp-3049	2	8	andel	andel	PROPN
fnp-3049	2	9	institute	institute	PROPN
fnp-3049	2	10	,	,	PUNCT
fnp-3049	2	11	grand	grand	PROPN
fnp-3049	2	12	rapids	rapids	PROPN
fnp-3049	2	13	,	,	PUNCT
fnp-3049	2	14	mi	mi	PROPN
fnp-3049	2	15	,	,	PUNCT
fnp-3049	2	16	usa	usa	PROPN
fnp-3049	2	17	.	.	PROPN
fnp-3049	2	18	4	4	NUM
fnp-3049	2	19	department	department	NOUN
fnp-3049	2	20	of	of	ADP
fnp-3049	2	21	physics	physics	PROPN
fnp-3049	2	22	,	,	PUNCT
fnp-3049	2	23	chemistry	chemistry	NOUN
fnp-3049	2	24	and	and	CCONJ
fnp-3049	2	25	biology	biology	NOUN
fnp-3049	2	26	,	,	PUNCT
fnp-3049	2	27	linköping	linköpe	VERB
fnp-3049	2	28	university	university	NOUN
fnp-3049	2	29	,	,	PUNCT
fnp-3049	2	30	linköping	linköpe	VERB
fnp-3049	2	31	,	,	PUNCT
fnp-3049	2	32	sweden	sweden	PROPN
fnp-3049	2	33	.	.	PROPN
fnp-3049	2	34	5	5	NUM
fnp-3049	2	35	metabolic	metabolic	NOUN
fnp-3049	2	36	solutions	solution	NOUN
fnp-3049	2	37	development	development	NOUN
fnp-3049	2	38	company	company	NOUN
fnp-3049	2	39	,	,	PUNCT
fnp-3049	2	40	kalamazoo	kalamazoo	PROPN
fnp-3049	2	41	,	,	PUNCT
fnp-3049	2	42	mi	mi	PROPN
fnp-3049	2	43	,	,	PUNCT
fnp-3049	2	44	usa	usa	PROPN
fnp-3049	2	45	.	.	PUNCT
fnp-3049	2	46	#	#	PROPN
fnp-3049	2	47	current	current	ADJ
fnp-3049	2	48	affiliation	affiliation	NOUN
fnp-3049	2	49	:	:	PUNCT
fnp-3049	2	50	dept	dept	NOUN
fnp-3049	2	51	.	.	PROPN
fnp-3049	3	1	of	of	ADP
fnp-3049	3	2	neurobiology	neurobiology	NOUN
fnp-3049	3	3	,	,	PUNCT
fnp-3049	3	4	care	care	NOUN
fnp-3049	3	5	sciences	science	NOUN
fnp-3049	3	6	and	and	CCONJ
fnp-3049	3	7	society	society	NOUN
fnp-3049	3	8	,	,	PUNCT
fnp-3049	3	9	karolinska	karolinska	PROPN
fnp-3049	3	10	institute	institute	PROPN
fnp-3049	3	11	,	,	PUNCT
fnp-3049	3	12	stockholm	stockholm	PROPN
fnp-3049	3	13	,	,	PUNCT
fnp-3049	3	14	sweden	sweden	PROPN
fnp-3049	3	15	.	.	PUNCT
fnp-3049	4	1	*	*	PUNCT
fnp-3049	4	2	these	these	DET
fnp-3049	4	3	authors	author	NOUN
fnp-3049	4	4	contributed	contribute	VERB
fnp-3049	4	5	equally	equally	ADV
fnp-3049	4	6	to	to	ADP
fnp-3049	4	7	this	this	DET
fnp-3049	4	8	work	work	NOUN
fnp-3049	4	9	.	.	PUNCT
fnp-3049	5	1	corresponding	correspond	VERB
fnp-3049	5	2	author	author	NOUN
fnp-3049	5	3	:	:	PUNCT
fnp-3049	5	4	patrik	patrik	PROPN
fnp-3049	5	5	brundin	brundin	PROPN
fnp-3049	5	6	·	·	PUNCT
fnp-3049	5	7	center	center	NOUN
fnp-3049	5	8	for	for	ADP
fnp-3049	5	9	neurodegenerative	neurodegenerative	ADJ
fnp-3049	5	10	science	science	NOUN
fnp-3049	5	11	·	·	PUNCT
fnp-3049	5	12	van	van	PROPN
fnp-3049	5	13	andel	andel	PROPN
fnp-3049	5	14	institute	institute	PROPN
fnp-3049	5	15	·	·	PUNCT
fnp-3049	5	16	grand	grand	PROPN
fnp-3049	5	17	rapids	rapids	PROPN
fnp-3049	5	18	,	,	PUNCT
fnp-3049	5	19	mi	mi	PROPN
fnp-3049	5	20	·	·	PROPN
fnp-3049	5	21	usa	usa	PROPN
fnp-3049	5	22	patrik.brundin@vai.org	patrik.brundin@vai.org	PROPN
fnp-3049	5	23	submitted	submit	VERB
fnp-3049	5	24	:	:	PUNCT
fnp-3049	5	25	01	01	NUM
fnp-3049	5	26	october	october	PROPN
fnp-3049	5	27	2020	2020	NUM
fnp-3049	5	28	accepted	accept	VERB
fnp-3049	5	29	:	:	PUNCT
fnp-3049	5	30	21	21	NUM
fnp-3049	5	31	november	november	PROPN
fnp-3049	5	32	2020	2020	NUM
fnp-3049	5	33	copyedited	copyedit	VERB
fnp-3049	5	34	by	by	ADP
fnp-3049	5	35	:	:	PUNCT
fnp-3049	5	36	jerry	jerry	PROPN
fnp-3049	5	37	j.	j.	PROPN
fnp-3049	5	38	lou	lou	PROPN
fnp-3049	5	39	published	publish	VERB
fnp-3049	5	40	:	:	PUNCT
fnp-3049	6	1	25	25	NUM
fnp-3049	6	2	november	november	PROPN
fnp-3049	6	3	2020	2020	NUM
fnp-3049	6	4	https://doi.org/10.17879/freeneuropathology-2020-3049	https://doi.org/10.17879/freeneuropathology-2020-3049	VERB
fnp-3049	6	5	additional	additional	ADJ
fnp-3049	6	6	resources	resource	NOUN
fnp-3049	6	7	and	and	CCONJ
fnp-3049	6	8	electronic	electronic	ADJ
fnp-3049	6	9	supplementary	supplementary	ADJ
fnp-3049	6	10	material	material	NOUN
fnp-3049	6	11	:	:	PUNCT
fnp-3049	6	12	supplementary	supplementary	ADJ
fnp-3049	6	13	material	material	NOUN
fnp-3049	6	14	keywords	keyword	NOUN
fnp-3049	6	15	:	:	PUNCT
fnp-3049	6	16	parkinson	parkinson	NOUN
fnp-3049	6	17	’s	’s	PART
fnp-3049	6	18	disease	disease	NOUN
fnp-3049	6	19	,	,	PUNCT
fnp-3049	6	20	synuclein	synuclein	NOUN
fnp-3049	6	21	,	,	PUNCT
fnp-3049	6	22	neurodegeneration	neurodegeneration	NOUN
fnp-3049	6	23	,	,	PUNCT
fnp-3049	6	24	metabolism	metabolism	NOUN
fnp-3049	6	25	,	,	PUNCT
fnp-3049	6	26	synucleinopathy	synucleinopathy	ADJ
fnp-3049	6	27	abstract	abstract	ADJ
fnp-3049	6	28	epidemiological	epidemiological	ADJ
fnp-3049	6	29	studies	study	NOUN
fnp-3049	6	30	suggest	suggest	VERB
fnp-3049	6	31	a	a	DET
fnp-3049	6	32	link	link	NOUN
fnp-3049	6	33	between	between	ADP
fnp-3049	6	34	type-2	type-2	NUM
fnp-3049	6	35	diabetes	diabetes	NOUN
fnp-3049	6	36	and	and	CCONJ
fnp-3049	6	37	parkinson	parkinson	NOUN
fnp-3049	6	38	’s	’s	PART
fnp-3049	6	39	disease	disease	NOUN
fnp-3049	6	40	(	(	PUNCT
fnp-3049	6	41	pd	pd	NOUN
fnp-3049	6	42	)	)	PUNCT
fnp-3049	6	43	risk	risk	NOUN
fnp-3049	6	44	.	.	PUNCT
fnp-3049	7	1	treatment	treatment	NOUN
fnp-3049	7	2	of	of	ADP
fnp-3049	7	3	type-2	type-2	NUM
fnp-3049	7	4	diabetes	diabetes	NOUN
fnp-3049	7	5	with	with	ADP
fnp-3049	7	6	insulin	insulin	NOUN
fnp-3049	7	7	sensitizing	sensitize	VERB
fnp-3049	7	8	drugs	drug	NOUN
fnp-3049	7	9	lowers	lower	VERB
fnp-3049	7	10	the	the	DET
fnp-3049	7	11	risk	risk	NOUN
fnp-3049	7	12	of	of	ADP
fnp-3049	7	13	pd	pd	PROPN
fnp-3049	7	14	.	.	PUNCT
fnp-3049	8	1	we	we	PRON
fnp-3049	8	2	previously	previously	ADV
fnp-3049	8	3	showed	show	VERB
fnp-3049	8	4	that	that	SCONJ
fnp-3049	8	5	the	the	DET
fnp-3049	8	6	insulin	insulin	NOUN
fnp-3049	8	7	sensitizing	sensitize	VERB
fnp-3049	8	8	drug	drug	NOUN
fnp-3049	8	9	,	,	PUNCT
fnp-3049	8	10	msdc-0160	msdc-0160	ADJ
fnp-3049	8	11	,	,	PUNCT
fnp-3049	8	12	ameliorates	ameliorate	VERB
fnp-3049	8	13	pathogenesis	pathogenesis	NOUN
fnp-3049	8	14	in	in	ADP
fnp-3049	8	15	some	some	DET
fnp-3049	8	16	animal	animal	NOUN
fnp-3049	8	17	models	model	NOUN
fnp-3049	8	18	of	of	ADP
fnp-3049	8	19	pd	pd	PROPN
fnp-3049	8	20	.	.	PUNCT
fnp-3049	9	1	msdc-0160	msdc-0160	PROPN
fnp-3049	9	2	reversibly	reversibly	ADV
fnp-3049	9	3	binds	bind	VERB
fnp-3049	9	4	the	the	DET
fnp-3049	9	5	mitochondrial	mitochondrial	ADJ
fnp-3049	9	6	pyruvate	pyruvate	NOUN
fnp-3049	9	7	carrier	carrier	NOUN
fnp-3049	9	8	(	(	PUNCT
fnp-3049	9	9	mpc	mpc	NOUN
fnp-3049	9	10	)	)	PUNCT
fnp-3049	9	11	protein	protein	NOUN
fnp-3049	9	12	complex	complex	NOUN
fnp-3049	9	13	,	,	PUNCT
fnp-3049	9	14	which	which	PRON
fnp-3049	9	15	has	have	VERB
fnp-3049	9	16	an	an	DET
fnp-3049	9	17	anti	anti	ADJ
fnp-3049	9	18	-	-	ADJ
fnp-3049	9	19	inflammatory	inflammatory	ADJ
fnp-3049	9	20	effect	effect	NOUN
fnp-3049	9	21	and	and	CCONJ
fnp-3049	9	22	restores	restore	VERB
fnp-3049	9	23	metabolic	metabolic	NOUN
fnp-3049	9	24	deficits	deficit	NOUN
fnp-3049	9	25	.	.	PUNCT
fnp-3049	10	1	since	since	SCONJ
fnp-3049	10	2	pd	pd	PROPN
fnp-3049	10	3	is	be	AUX
fnp-3049	10	4	characterized	characterize	VERB
fnp-3049	10	5	by	by	ADP
fnp-3049	10	6	the	the	DET
fnp-3049	10	7	deposition	deposition	NOUN
fnp-3049	10	8	of	of	ADP
fnp-3049	10	9	α	α	NOUN
fnp-3049	10	10	-	-	PUNCT
fnp-3049	10	11	synuclein	synuclein	NOUN
fnp-3049	10	12	(	(	PUNCT
fnp-3049	10	13	αsyn	αsyn	PROPN
fnp-3049	10	14	)	)	PUNCT
fnp-3049	10	15	,	,	PUNCT
fnp-3049	10	16	we	we	PRON
fnp-3049	10	17	hypothesized	hypothesize	VERB
fnp-3049	10	18	that	that	SCONJ
fnp-3049	10	19	inhibiting	inhibit	VERB
fnp-3049	10	20	the	the	DET
fnp-3049	10	21	mpc	mpc	NOUN
fnp-3049	10	22	might	might	AUX
fnp-3049	10	23	directly	directly	ADV
fnp-3049	10	24	inhibit	inhibit	VERB
fnp-3049	10	25	αsyn	αsyn	ADJ
fnp-3049	10	26	aggregation	aggregation	NOUN
fnp-3049	10	27	in	in	ADP
fnp-3049	10	28	vivo	vivo	NOUN
fnp-3049	10	29	in	in	ADP
fnp-3049	10	30	mammals	mammal	NOUN
fnp-3049	10	31	.	.	PUNCT
fnp-3049	11	1	to	to	PART
fnp-3049	11	2	answer	answer	VERB
fnp-3049	11	3	if	if	SCONJ
fnp-3049	11	4	modulation	modulation	NOUN
fnp-3049	11	5	of	of	ADP
fnp-3049	11	6	mpc	mpc	PROPN
fnp-3049	11	7	can	can	AUX
fnp-3049	11	8	reduce	reduce	VERB
fnp-3049	11	9	the	the	DET
fnp-3049	11	10	development	development	NOUN
fnp-3049	11	11	of	of	ADP
fnp-3049	11	12	αsyn	αsyn	ADJ
fnp-3049	11	13	assemblies	assembly	NOUN
fnp-3049	11	14	,	,	PUNCT
fnp-3049	11	15	and	and	CCONJ
fnp-3049	11	16	reduce	reduce	VERB
fnp-3049	11	17	neurodegeneration	neurodegeneration	NOUN
fnp-3049	11	18	,	,	PUNCT
fnp-3049	11	19	we	we	PRON
fnp-3049	11	20	treated	treat	VERB
fnp-3049	11	21	two	two	NUM
fnp-3049	11	22	chronic	chronic	ADJ
fnp-3049	11	23	and	and	CCONJ
fnp-3049	11	24	progressive	progressive	ADJ
fnp-3049	11	25	mouse	mouse	NOUN
fnp-3049	11	26	models	model	NOUN
fnp-3049	11	27	;	;	PUNCT
fnp-3049	11	28	a	a	DET
fnp-3049	11	29	viral	viral	ADJ
fnp-3049	11	30	vector	vector	NOUN
fnp-3049	11	31	-	-	PUNCT
fnp-3049	11	32	based	base	VERB
fnp-3049	11	33	αsyn	αsyn	PROPN
fnp-3049	11	34	overexpressing	overexpresse	VERB
fnp-3049	11	35	model	model	NOUN
fnp-3049	11	36	and	and	CCONJ
fnp-3049	11	37	a	a	DET
fnp-3049	11	38	pre	pre	ADJ
fnp-3049	11	39	-	-	ADJ
fnp-3049	11	40	formed	form	VERB
fnp-3049	11	41	fibril	fibril	ADJ
fnp-3049	11	42	(	(	PUNCT
fnp-3049	11	43	pff	pff	PROPN
fnp-3049	11	44	)	)	PUNCT
fnp-3049	11	45	αsyn	αsyn	NOUN
fnp-3049	11	46	seeding	seeding	NOUN
fnp-3049	11	47	model	model	NOUN
fnp-3049	11	48	with	with	ADP
fnp-3049	11	49	msdc-0160	msdc-0160	NOUN
fnp-3049	11	50	.	.	PUNCT
fnp-3049	12	1	these	these	DET
fnp-3049	12	2	two	two	NUM
fnp-3049	12	3	models	model	NOUN
fnp-3049	12	4	present	present	VERB
fnp-3049	12	5	distinct	distinct	ADJ
fnp-3049	12	6	types	type	NOUN
fnp-3049	12	7	of	of	ADP
fnp-3049	12	8	αsyn	αsyn	ADJ
fnp-3049	12	9	pathology	pathology	NOUN
fnp-3049	12	10	but	but	CCONJ
fnp-3049	12	11	lack	lack	VERB
fnp-3049	12	12	inflammatory	inflammatory	ADJ
fnp-3049	12	13	or	or	CCONJ
fnp-3049	12	14	autophagy	autophagy	ADJ
fnp-3049	12	15	deficits	deficit	NOUN
fnp-3049	12	16	.	.	PUNCT
fnp-3049	13	1	contrary	contrary	ADJ
fnp-3049	13	2	to	to	ADP
fnp-3049	13	3	our	our	PRON
fnp-3049	13	4	hypothesis	hypothesis	NOUN
fnp-3049	13	5	,	,	PUNCT
fnp-3049	13	6	we	we	PRON
fnp-3049	13	7	found	find	VERB
fnp-3049	13	8	that	that	SCONJ
fnp-3049	13	9	a	a	DET
fnp-3049	13	10	modulation	modulation	NOUN
fnp-3049	13	11	of	of	ADP
fnp-3049	13	12	mpc	mpc	PROPN
fnp-3049	13	13	in	in	ADP
fnp-3049	13	14	these	these	DET
fnp-3049	13	15	models	model	NOUN
fnp-3049	13	16	did	do	AUX
fnp-3049	13	17	not	not	PART
fnp-3049	13	18	reduce	reduce	VERB
fnp-3049	13	19	the	the	DET
fnp-3049	13	20	accumulation	accumulation	NOUN
fnp-3049	13	21	of	of	ADP
fnp-3049	13	22	αsyn	αsyn	ADJ
fnp-3049	13	23	aggregates	aggregate	NOUN
fnp-3049	13	24	or	or	CCONJ
fnp-3049	13	25	mitigate	mitigate	VERB
fnp-3049	13	26	neurotoxicity	neurotoxicity	NOUN
fnp-3049	13	27	.	.	PUNCT
fnp-3049	14	1	instead	instead	ADV
fnp-3049	14	2	,	,	PUNCT
fnp-3049	14	3	msdc-0160	msdc-0160	NOUN
fnp-3049	14	4	changed	change	VERB
fnp-3049	14	5	the	the	DET
fnp-3049	14	6	post	post	ADJ
fnp-3049	14	7	-	-	ADJ
fnp-3049	14	8	translational	translational	ADJ
fnp-3049	14	9	modification	modification	NOUN
fnp-3049	14	10	and	and	CCONJ
fnp-3049	14	11	aggregation	aggregation	NOUN
fnp-3049	14	12	features	feature	NOUN
fnp-3049	14	13	of	of	ADP
fnp-3049	14	14	αsyn	αsyn	PROPN
fnp-3049	14	15	.	.	PUNCT
fnp-3049	15	1	these	these	DET
fnp-3049	15	2	results	result	NOUN
fnp-3049	15	3	are	be	AUX
fnp-3049	15	4	consistent	consistent	ADJ
fnp-3049	15	5	with	with	ADP
fnp-3049	15	6	the	the	DET
fnp-3049	15	7	lack	lack	NOUN
fnp-3049	15	8	of	of	ADP
fnp-3049	15	9	a	a	DET
fnp-3049	15	10	direct	direct	ADJ
fnp-3049	15	11	effect	effect	NOUN
fnp-3049	15	12	of	of	ADP
fnp-3049	15	13	mpc	mpc	NOUN
fnp-3049	15	14	modulation	modulation	NOUN
fnp-3049	15	15	on	on	ADP
fnp-3049	15	16	synuclein	synuclein	NOUN
fnp-3049	15	17	clearance	clearance	NOUN
fnp-3049	15	18	in	in	ADP
fnp-3049	15	19	these	these	DET
fnp-3049	15	20	models	model	NOUN
fnp-3049	15	21	.	.	PUNCT
fnp-3049	16	1	introduction	introduction	NOUN
fnp-3049	16	2	synucleinopathies	synucleinopathie	NOUN
fnp-3049	16	3	are	be	AUX
fnp-3049	16	4	age	age	NOUN
fnp-3049	16	5	-	-	PUNCT
fnp-3049	16	6	related	relate	VERB
fnp-3049	16	7	neurodegenerative	neurodegenerative	ADJ
fnp-3049	16	8	diseases	disease	NOUN
fnp-3049	16	9	characterized	characterize	VERB
fnp-3049	16	10	by	by	ADP
fnp-3049	16	11	α	α	PROPN
fnp-3049	16	12	-	-	PUNCT
fnp-3049	16	13	synuclein	synuclein	NOUN
fnp-3049	16	14	(	(	PUNCT
fnp-3049	16	15	αsyn	αsyn	NOUN
fnp-3049	16	16	)	)	PUNCT
fnp-3049	16	17	protein	protein	NOUN
fnp-3049	16	18	misfolding	misfolding	NOUN
fnp-3049	16	19	,	,	PUNCT
fnp-3049	16	20	inflammation	inflammation	NOUN
fnp-3049	16	21	and	and	CCONJ
fnp-3049	16	22	metabolic	metabolic	NOUN
fnp-3049	16	23	deficits	deficit	NOUN
fnp-3049	16	24	.	.	PUNCT
fnp-3049	17	1	people	people	NOUN
fnp-3049	17	2	with	with	ADP
fnp-3049	17	3	parkinson	parkinson	NOUN
fnp-3049	17	4	’s	’s	PART
fnp-3049	17	5	disease	disease	NOUN
fnp-3049	17	6	(	(	PUNCT
fnp-3049	17	7	pd	pd	NOUN
fnp-3049	17	8	)	)	PUNCT
fnp-3049	17	9	,	,	PUNCT
fnp-3049	17	10	dementia	dementia	NOUN
fnp-3049	17	11	with	with	ADP
fnp-3049	17	12	lewy	lewy	ADJ
fnp-3049	17	13	bodies	body	NOUN
fnp-3049	17	14	(	(	PUNCT
fnp-3049	17	15	dlb	dlb	NOUN
fnp-3049	17	16	)	)	PUNCT
fnp-3049	17	17	and	and	CCONJ
fnp-3049	17	18	multiple	multiple	ADJ
fnp-3049	17	19	system	system	NOUN
fnp-3049	17	20	atrophy	atrophy	NOUN
fnp-3049	17	21	(	(	PUNCT
fnp-3049	17	22	msa	msa	PROPN
fnp-3049	17	23	)	)	PUNCT
fnp-3049	17	24	present	present	ADJ
fnp-3049	17	25	with	with	ADP
fnp-3049	17	26	peripheral	peripheral	ADJ
fnp-3049	17	27	and	and	CCONJ
fnp-3049	17	28	central	central	ADJ
fnp-3049	17	29	synucleinopathies	synucleinopathie	NOUN
fnp-3049	17	30	that	that	PRON
fnp-3049	17	31	coincide	coincide	VERB
fnp-3049	17	32	with	with	ADP
fnp-3049	17	33	a	a	DET
fnp-3049	17	34	wide	wide	ADJ
fnp-3049	17	35	range	range	NOUN
fnp-3049	17	36	of	of	ADP
fnp-3049	17	37	non	non	ADJ
fnp-3049	17	38	-	-	NOUN
fnp-3049	17	39	motor	motor	ADJ
fnp-3049	17	40	(	(	PUNCT
fnp-3049	17	41	e.g.	e.g.	ADJ
fnp-3049	17	42	,	,	PUNCT
fnp-3049	17	43	hyposmia	hyposmia	NOUN
fnp-3049	17	44	,	,	PUNCT
fnp-3049	17	45	constipation	constipation	NOUN
fnp-3049	17	46	and	and	CCONJ
fnp-3049	17	47	rapid	rapid	ADJ
fnp-3049	17	48	eye	eye	NOUN
fnp-3049	17	49	movement	movement	NOUN
fnp-3049	17	50	sleep	sleep	NOUN
fnp-3049	17	51	behavior	behavior	NOUN
fnp-3049	17	52	disorder	disorder	NOUN
fnp-3049	17	53	)	)	PUNCT
fnp-3049	17	54	and	and	CCONJ
fnp-3049	17	55	classical	classical	ADJ
fnp-3049	17	56	motor	motor	NOUN
fnp-3049	17	57	symptoms1	symptoms1	NOUN
fnp-3049	17	58	.	.	PUNCT
fnp-3049	18	1	the	the	DET
fnp-3049	18	2	disease	disease	NOUN
fnp-3049	18	3	mechanisms	mechanism	VERB
fnp-3049	18	4	underlying	underlying	ADJ
fnp-3049	18	5	synucleinopathies	synucleinopathie	NOUN
fnp-3049	18	6	are	be	AUX
fnp-3049	18	7	not	not	PART
fnp-3049	18	8	completely	completely	ADV
fnp-3049	18	9	understood	understand	VERB
fnp-3049	18	10	,	,	PUNCT
fnp-3049	18	11	but	but	CCONJ
fnp-3049	18	12	evidence	evidence	NOUN
fnp-3049	18	13	suggests	suggest	VERB
fnp-3049	18	14	that	that	SCONJ
fnp-3049	18	15	mitochondrial	mitochondrial	ADJ
fnp-3049	18	16	dysfunction	dysfunction	NOUN
fnp-3049	18	17	,	,	PUNCT
fnp-3049	18	18	neuroinflammation	neuroinflammation	NOUN
fnp-3049	18	19	and	and	CCONJ
fnp-3049	18	20	altered	alter	VERB
fnp-3049	18	21	protein	protein	NOUN
fnp-3049	18	22	homeostasis	homeostasis	NOUN
fnp-3049	18	23	all	all	PRON
fnp-3049	18	24	play	play	VERB
fnp-3049	18	25	a	a	DET
fnp-3049	18	26	role	role	NOUN
fnp-3049	18	27	,	,	PUNCT
fnp-3049	18	28	as	as	SCONJ
fnp-3049	18	29	reviewed	review	VERB
fnp-3049	18	30	in	in	ADP
fnp-3049	18	31	detail	detail	NOUN
fnp-3049	18	32	elsewhere2	elsewhere2	ADJ
fnp-3049	18	33	.	.	PUNCT
fnp-3049	19	1	epidemiological	epidemiological	ADJ
fnp-3049	19	2	studies	study	NOUN
fnp-3049	19	3	have	have	AUX
fnp-3049	19	4	indicated	indicate	VERB
fnp-3049	19	5	a	a	DET
fnp-3049	19	6	link	link	NOUN
fnp-3049	19	7	between	between	ADP
fnp-3049	19	8	pd	pd	PROPN
fnp-3049	19	9	and	and	CCONJ
fnp-3049	19	10	type	type	NOUN
fnp-3049	19	11	2	2	NUM
fnp-3049	19	12	diabetes3	diabetes3	NOUN
fnp-3049	19	13	-	-	PUNCT
fnp-3049	19	14	5	5	NUM
fnp-3049	19	15	.	.	PUNCT
fnp-3049	19	16	type	type	NOUN
fnp-3049	19	17	2	2	NUM
fnp-3049	19	18	diabetes	diabetes	NOUN
fnp-3049	19	19	is	be	AUX
fnp-3049	19	20	associated	associate	VERB
fnp-3049	19	21	with	with	ADP
fnp-3049	19	22	a	a	DET
fnp-3049	19	23	38	38	NUM
fnp-3049	19	24	%	%	NOUN
fnp-3049	19	25	increased	increase	VERB
fnp-3049	19	26	risk	risk	NOUN
fnp-3049	19	27	of	of	ADP
fnp-3049	19	28	developing	develop	VERB
fnp-3049	19	29	pd3,4	pd3,4	NOUN
fnp-3049	19	30	.	.	PUNCT
fnp-3049	20	1	on	on	ADP
fnp-3049	20	2	a	a	DET
fnp-3049	20	3	molecular	molecular	ADJ
fnp-3049	20	4	level	level	NOUN
fnp-3049	20	5	,	,	PUNCT
fnp-3049	20	6	both	both	DET
fnp-3049	20	7	people	people	NOUN
fnp-3049	20	8	with	with	ADP
fnp-3049	20	9	pd	pd	PROPN
fnp-3049	20	10	and	and	CCONJ
fnp-3049	20	11	those	those	PRON
fnp-3049	20	12	with	with	ADP
fnp-3049	20	13	type	type	NOUN
fnp-3049	20	14	2	2	NUM
fnp-3049	20	15	diabetes	diabetes	NOUN
fnp-3049	20	16	have	have	VERB
fnp-3049	20	17	similar	similar	ADJ
fnp-3049	20	18	metabolic	metabolic	NOUN
fnp-3049	20	19	abnormalities	abnormality	NOUN
fnp-3049	20	20	such	such	ADJ
fnp-3049	20	21	as	as	ADP
fnp-3049	20	22	mitochondrial	mitochondrial	ADJ
fnp-3049	20	23	dysfunction	dysfunction	NOUN
fnp-3049	20	24	and	and	CCONJ
fnp-3049	20	25	insulin	insulin	NOUN
fnp-3049	20	26	resistance5	resistance5	NOUN
fnp-3049	20	27	.	.	PUNCT
fnp-3049	21	1	given	give	VERB
fnp-3049	21	2	these	these	DET
fnp-3049	21	3	links	link	NOUN
fnp-3049	21	4	between	between	ADP
fnp-3049	21	5	pd	pd	NOUN
fnp-3049	21	6	and	and	CCONJ
fnp-3049	21	7	metabolic	metabolic	NOUN
fnp-3049	21	8	dysfunction	dysfunction	NOUN
fnp-3049	21	9	,	,	PUNCT
fnp-3049	21	10	clinical	clinical	ADJ
fnp-3049	21	11	trials	trial	NOUN
fnp-3049	21	12	in	in	ADP
fnp-3049	21	13	pd	pd	PROPN
fnp-3049	21	14	were	be	AUX
fnp-3049	21	15	initiated	initiate	VERB
fnp-3049	21	16	to	to	PART
fnp-3049	21	17	test	test	VERB
fnp-3049	21	18	drugs	drug	NOUN
fnp-3049	21	19	already	already	ADV
fnp-3049	21	20	approved	approve	VERB
fnp-3049	21	21	for	for	ADP
fnp-3049	21	22	the	the	DET
fnp-3049	21	23	treatment	treatment	NOUN
fnp-3049	21	24	of	of	ADP
fnp-3049	21	25	diabetes	diabetes	NOUN
fnp-3049	21	26	.	.	PUNCT
fnp-3049	22	1	in	in	ADP
fnp-3049	22	2	a	a	DET
fnp-3049	22	3	randomized	randomized	ADJ
fnp-3049	22	4	,	,	PUNCT
fnp-3049	22	5	double	double	ADJ
fnp-3049	22	6	-	-	PUNCT
fnp-3049	22	7	blinded	blind	VERB
fnp-3049	22	8	placebo	placebo	NOUN
fnp-3049	22	9	-	-	PUNCT
fnp-3049	22	10	controlled	control	VERB
fnp-3049	22	11	trial	trial	NOUN
fnp-3049	22	12	with	with	ADP
fnp-3049	22	13	the	the	DET
fnp-3049	22	14	brain	brain	NOUN
fnp-3049	22	15	penetrant	penetrant	NOUN
fnp-3049	22	16	insulin	insulin	NOUN
fnp-3049	22	17	sensitizing	sensitize	VERB
fnp-3049	22	18	glucagon	glucagon	NOUN
fnp-3049	22	19	-	-	PUNCT
fnp-3049	22	20	like	like	ADJ
fnp-3049	22	21	peptide	peptide	NOUN
fnp-3049	22	22	1	1	NUM
fnp-3049	22	23	(	(	PUNCT
fnp-3049	22	24	glp1)-agonist	glp1)-agonist	X
fnp-3049	22	25	exenatide	exenatide	ADV
fnp-3049	22	26	,	,	PUNCT
fnp-3049	22	27	it	it	PRON
fnp-3049	22	28	was	be	AUX
fnp-3049	22	29	shown	show	VERB
fnp-3049	22	30	that	that	SCONJ
fnp-3049	22	31	exenatide	exenatide	NOUN
fnp-3049	22	32	treatment	treatment	NOUN
fnp-3049	22	33	was	be	AUX
fnp-3049	22	34	associated	associate	VERB
fnp-3049	22	35	with	with	ADP
fnp-3049	22	36	a	a	DET
fnp-3049	22	37	reduced	reduce	VERB
fnp-3049	22	38	decline	decline	NOUN
fnp-3049	22	39	in	in	ADP
fnp-3049	22	40	motor	motor	NOUN
fnp-3049	22	41	dysfunction	dysfunction	NOUN
fnp-3049	22	42	in	in	ADP
fnp-3049	22	43	pd	pd	NOUN
fnp-3049	22	44	patients6	patients6	X
fnp-3049	22	45	.	.	PUNCT
fnp-3049	23	1	specifically	specifically	ADV
fnp-3049	23	2	,	,	PUNCT
fnp-3049	23	3	once	once	ADV
fnp-3049	23	4	-	-	PUNCT
fnp-3049	23	5	weekly	weekly	ADJ
fnp-3049	23	6	injections	injection	NOUN
fnp-3049	23	7	of	of	ADP
fnp-3049	23	8	the	the	DET
fnp-3049	23	9	slow	slow	ADJ
fnp-3049	23	10	release	release	NOUN
fnp-3049	23	11	form	form	NOUN
fnp-3049	23	12	of	of	ADP
fnp-3049	23	13	exenatide	exenatide	NOUN
fnp-3049	23	14	for	for	ADP
fnp-3049	23	15	48	48	NUM
fnp-3049	23	16	weeks	week	NOUN
fnp-3049	23	17	resulted	result	VERB
fnp-3049	23	18	in	in	ADP
fnp-3049	23	19	improvements	improvement	NOUN
fnp-3049	23	20	in	in	ADP
fnp-3049	23	21	the	the	DET
fnp-3049	23	22	mds	mds	NOUN
fnp-3049	23	23	-	-	PUNCT
fnp-3049	23	24	updrs	updrs	X
fnp-3049	23	25	(	(	PUNCT
fnp-3049	23	26	part	part	NOUN
fnp-3049	23	27	iii)-defined	iii)-define	VERB
fnp-3049	23	28	primary	primary	ADJ
fnp-3049	23	29	endpoint	endpoint	NOUN
fnp-3049	23	30	with	with	ADP
fnp-3049	23	31	effects	effect	NOUN
fnp-3049	23	32	persisting	persist	VERB
fnp-3049	23	33	after	after	ADP
fnp-3049	23	34	a	a	DET
fnp-3049	23	35	12	12	NUM
fnp-3049	23	36	-	-	PUNCT
fnp-3049	23	37	week	week	NOUN
fnp-3049	23	38	wash	wash	NOUN
fnp-3049	23	39	out	out	ADP
fnp-3049	23	40	period6	period6	VERB
fnp-3049	23	41	.	.	PUNCT
fnp-3049	24	1	in	in	ADP
fnp-3049	24	2	a	a	DET
fnp-3049	24	3	post	post	X
fnp-3049	24	4	hoc	hoc	X
fnp-3049	24	5	analysis	analysis	NOUN
fnp-3049	24	6	evaluating	evaluate	VERB
fnp-3049	24	7	non	non	ADJ
fnp-3049	24	8	-	-	ADJ
fnp-3049	24	9	motor	motor	ADJ
fnp-3049	24	10	symptoms	symptom	NOUN
fnp-3049	24	11	,	,	PUNCT
fnp-3049	24	12	secondary	secondary	ADJ
fnp-3049	24	13	end	end	NOUN
fnp-3049	24	14	points	point	NOUN
fnp-3049	24	15	such	such	ADJ
fnp-3049	24	16	as	as	ADP
fnp-3049	24	17	patient	patient	ADJ
fnp-3049	24	18	and	and	CCONJ
fnp-3049	24	19	observer	observer	NOUN
fnp-3049	24	20	-	-	PUNCT
fnp-3049	24	21	led	lead	VERB
fnp-3049	24	22	scales	scale	NOUN
fnp-3049	24	23	assessing	assess	VERB
fnp-3049	24	24	mood	mood	NOUN
fnp-3049	24	25	also	also	ADV
fnp-3049	24	26	showed	show	VERB
fnp-3049	24	27	positive	positive	ADJ
fnp-3049	24	28	effects	effect	NOUN
fnp-3049	24	29	from	from	ADP
fnp-3049	24	30	the	the	DET
fnp-3049	24	31	treatment7	treatment7	NOUN
fnp-3049	24	32	.	.	PUNCT
fnp-3049	25	1	exenatide	exenatide	PROPN
fnp-3049	25	2	is	be	AUX
fnp-3049	25	3	currently	currently	ADV
fnp-3049	25	4	in	in	ADP
fnp-3049	25	5	a	a	DET
fnp-3049	25	6	phase	phase	NOUN
fnp-3049	25	7	iii	iii	NOUN
fnp-3049	25	8	trial	trial	NOUN
fnp-3049	25	9	in	in	ADP
fnp-3049	25	10	200	200	NUM
fnp-3049	25	11	pd	pd	NOUN
fnp-3049	25	12	patients	patient	NOUN
fnp-3049	25	13	who	who	PRON
fnp-3049	25	14	will	will	AUX
fnp-3049	25	15	be	be	AUX
fnp-3049	25	16	treated	treat	VERB
fnp-3049	25	17	for	for	ADP
fnp-3049	25	18	2	2	NUM
fnp-3049	25	19	years	year	NOUN
fnp-3049	25	20	,	,	PUNCT
fnp-3049	25	21	with	with	SCONJ
fnp-3049	25	22	the	the	DET
fnp-3049	25	23	primary	primary	ADJ
fnp-3049	25	24	endpoint	endpoint	NOUN
fnp-3049	25	25	focused	focus	VERB
fnp-3049	25	26	on	on	ADP
fnp-3049	25	27	disease	disease	NOUN
fnp-3049	25	28	modification	modification	NOUN
fnp-3049	25	29	(	(	PUNCT
fnp-3049	25	30	clinicaltrials.gov	clinicaltrials.gov	X
fnp-3049	25	31	identifier	identifier	NOUN
fnp-3049	25	32	nct0423296	nct0423296	NOUN
fnp-3049	25	33	)	)	PUNCT
fnp-3049	25	34	.	.	PUNCT
fnp-3049	26	1	a	a	DET
fnp-3049	26	2	second	second	ADJ
fnp-3049	26	3	insulin	insulin	NOUN
fnp-3049	26	4	sensitizer	sensitizer	NOUN
fnp-3049	26	5	that	that	PRON
fnp-3049	26	6	has	have	AUX
fnp-3049	26	7	been	be	AUX
fnp-3049	26	8	associated	associate	VERB
fnp-3049	26	9	with	with	ADP
fnp-3049	26	10	a	a	DET
fnp-3049	26	11	lower	low	ADJ
fnp-3049	26	12	risk	risk	NOUN
fnp-3049	26	13	of	of	ADP
fnp-3049	26	14	pd	pd	PROPN
fnp-3049	26	15	is	be	AUX
fnp-3049	26	16	pioglitazone3,4	pioglitazone3,4	PROPN
fnp-3049	26	17	.	.	PUNCT
fnp-3049	27	1	however	however	ADV
fnp-3049	27	2	,	,	PUNCT
fnp-3049	27	3	when	when	SCONJ
fnp-3049	27	4	evaluated	evaluate	VERB
fnp-3049	27	5	in	in	ADP
fnp-3049	27	6	a	a	DET
fnp-3049	27	7	phase	phase	NOUN
fnp-3049	27	8	2	2	NUM
fnp-3049	27	9	clinical	clinical	ADJ
fnp-3049	27	10	pd	pd	NOUN
fnp-3049	27	11	trial	trial	NOUN
fnp-3049	27	12	,	,	PUNCT
fnp-3049	27	13	pioglitazone	pioglitazone	NOUN
fnp-3049	27	14	did	do	AUX
fnp-3049	27	15	not	not	PART
fnp-3049	27	16	have	have	VERB
fnp-3049	27	17	any	any	DET
fnp-3049	27	18	significant	significant	ADJ
fnp-3049	27	19	effect	effect	NOUN
fnp-3049	27	20	on	on	ADP
fnp-3049	27	21	disease	disease	NOUN
fnp-3049	27	22	progression	progression	NOUN
fnp-3049	27	23	as	as	SCONJ
fnp-3049	27	24	measured	measure	VERB
fnp-3049	27	25	via	via	ADP
fnp-3049	27	26	msd	msd	NOUN
fnp-3049	27	27	-	-	PUNCT
fnp-3049	27	28	updrs	updrs	X
fnp-3049	27	29	(	(	PUNCT
fnp-3049	27	30	part	part	NOUN
fnp-3049	27	31	iii)8	iii)8	PROPN
fnp-3049	27	32	.	.	PUNCT
fnp-3049	28	1	pioglitazone	pioglitazone	NOUN
fnp-3049	28	2	belongs	belong	VERB
fnp-3049	28	3	to	to	ADP
fnp-3049	28	4	a	a	DET
fnp-3049	28	5	class	class	NOUN
fnp-3049	28	6	of	of	ADP
fnp-3049	28	7	anti	anti	ADJ
fnp-3049	28	8	-	-	ADJ
fnp-3049	28	9	diabetic	diabetic	ADJ
fnp-3049	28	10	drugs	drug	NOUN
fnp-3049	28	11	,	,	PUNCT
fnp-3049	28	12	termed	term	VERB
fnp-3049	28	13	thiazolidinediones	thiazolidinedione	NOUN
fnp-3049	28	14	or	or	CCONJ
fnp-3049	28	15	tzds	tzds	ADJ
fnp-3049	28	16	,	,	PUNCT
fnp-3049	28	17	and	and	CCONJ
fnp-3049	28	18	was	be	AUX
fnp-3049	28	19	believed	believe	VERB
fnp-3049	28	20	to	to	PART
fnp-3049	28	21	exert	exert	VERB
fnp-3049	28	22	its	its	PRON
fnp-3049	28	23	anti	anti	ADJ
fnp-3049	28	24	-	-	ADJ
fnp-3049	28	25	diabetic	diabetic	ADJ
fnp-3049	28	26	effects	effect	NOUN
fnp-3049	28	27	via	via	ADP
fnp-3049	28	28	activation	activation	NOUN
fnp-3049	28	29	of	of	ADP
fnp-3049	28	30	the	the	DET
fnp-3049	28	31	transcription	transcription	NOUN
fnp-3049	28	32	factor	factor	NOUN
fnp-3049	28	33	peroxisome	peroxisome	VERB
fnp-3049	28	34	proliferator	proliferator	NOUN
fnp-3049	28	35	-	-	PUNCT
fnp-3049	28	36	activated	activate	VERB
fnp-3049	28	37	receptor	receptor	NOUN
fnp-3049	28	38	-	-	PUNCT
fnp-3049	28	39	γ	γ	NOUN
fnp-3049	28	40	(	(	PUNCT
fnp-3049	28	41	pparγ	pparγ	NOUN
fnp-3049	28	42	)	)	PUNCT
fnp-3049	28	43	.	.	PUNCT
fnp-3049	29	1	due	due	ADP
fnp-3049	29	2	to	to	ADP
fnp-3049	29	3	strong	strong	ADJ
fnp-3049	29	4	binding	binding	NOUN
fnp-3049	29	5	of	of	ADP
fnp-3049	29	6	pioglitazone	pioglitazone	NOUN
fnp-3049	29	7	to	to	PART
fnp-3049	29	8	pparγ	pparγ	VERB
fnp-3049	29	9	the	the	DET
fnp-3049	29	10	drug	drug	NOUN
fnp-3049	29	11	has	have	VERB
fnp-3049	29	12	several	several	ADJ
fnp-3049	29	13	negative	negative	ADJ
fnp-3049	29	14	side	side	NOUN
fnp-3049	29	15	effects	effect	NOUN
fnp-3049	29	16	.	.	PUNCT
fnp-3049	30	1	as	as	ADP
fnp-3049	30	2	a	a	DET
fnp-3049	30	3	result	result	NOUN
fnp-3049	30	4	,	,	PUNCT
fnp-3049	30	5	pparγ	pparγ	NOUN
fnp-3049	30	6	-	-	PUNCT
fnp-3049	30	7	sparing	spare	VERB
fnp-3049	30	8	tzds	tzds	ADJ
fnp-3049	30	9	,	,	PUNCT
fnp-3049	30	10	including	include	VERB
fnp-3049	30	11	msdc-0160	msdc-0160	ADJ
fnp-3049	30	12	were	be	AUX
fnp-3049	30	13	developed	develop	VERB
fnp-3049	30	14	.	.	PUNCT
fnp-3049	31	1	interestingly	interestingly	ADV
fnp-3049	31	2	,	,	PUNCT
fnp-3049	31	3	when	when	SCONJ
fnp-3049	31	4	compared	compare	VERB
fnp-3049	31	5	to	to	ADP
fnp-3049	31	6	pioglitazone	pioglitazone	NOUN
fnp-3049	31	7	,	,	PUNCT
fnp-3049	31	8	msdc-0160	msdc-0160	NOUN
fnp-3049	31	9	has	have	VERB
fnp-3049	31	10	similar	similar	ADJ
fnp-3049	31	11	anti	anti	ADJ
fnp-3049	31	12	-	-	ADJ
fnp-3049	31	13	diabetic	diabetic	ADJ
fnp-3049	31	14	effects	effect	NOUN
fnp-3049	31	15	but	but	CCONJ
fnp-3049	31	16	it	it	PRON
fnp-3049	31	17	does	do	AUX
fnp-3049	31	18	not	not	PART
fnp-3049	31	19	activate	activate	VERB
fnp-3049	31	20	pparγ	pparγ	ADJ
fnp-3049	31	21	,	,	PUNCT
fnp-3049	31	22	indicating	indicate	VERB
fnp-3049	31	23	that	that	SCONJ
fnp-3049	31	24	tzds	tzds	ADJ
fnp-3049	31	25	act	act	NOUN
fnp-3049	31	26	on	on	ADP
fnp-3049	31	27	a	a	DET
fnp-3049	31	28	different	different	ADJ
fnp-3049	31	29	receptor	receptor	NOUN
fnp-3049	31	30	to	to	PART
fnp-3049	31	31	elicit	elicit	VERB
fnp-3049	31	32	effects	effect	NOUN
fnp-3049	31	33	.	.	PUNCT
fnp-3049	32	1	the	the	DET
fnp-3049	32	2	primary	primary	ADJ
fnp-3049	32	3	target	target	NOUN
fnp-3049	32	4	was	be	AUX
fnp-3049	32	5	later	later	ADV
fnp-3049	32	6	found	find	VERB
fnp-3049	32	7	on	on	ADP
fnp-3049	32	8	the	the	DET
fnp-3049	32	9	inner	inner	ADJ
fnp-3049	32	10	membrane	membrane	NOUN
fnp-3049	32	11	of	of	ADP
fnp-3049	32	12	mitochondria	mitochondria	NOUN
fnp-3049	32	13	and	and	CCONJ
fnp-3049	32	14	was	be	AUX
fnp-3049	32	15	identified	identify	VERB
fnp-3049	32	16	as	as	ADP
fnp-3049	32	17	the	the	DET
fnp-3049	32	18	previously	previously	ADV
fnp-3049	32	19	unknown	unknown	ADJ
fnp-3049	32	20	mitochondrial	mitochondrial	ADJ
fnp-3049	32	21	pyruvate	pyruvate	NOUN
fnp-3049	32	22	carrier	carrier	NOUN
fnp-3049	32	23	(	(	PUNCT
fnp-3049	32	24	mpc)9	mpc)9	PROPN
fnp-3049	32	25	.	.	PUNCT
fnp-3049	33	1	because	because	SCONJ
fnp-3049	33	2	of	of	ADP
fnp-3049	33	3	the	the	DET
fnp-3049	33	4	link	link	NOUN
fnp-3049	33	5	between	between	ADP
fnp-3049	33	6	tzds	tzds	ADJ
fnp-3049	33	7	and	and	CCONJ
fnp-3049	33	8	a	a	DET
fnp-3049	33	9	lowered	lower	VERB
fnp-3049	33	10	associated	associated	ADJ
fnp-3049	33	11	risk	risk	NOUN
fnp-3049	33	12	of	of	ADP
fnp-3049	33	13	pd	pd	PROPN
fnp-3049	33	14	,	,	PUNCT
fnp-3049	33	15	msdc-0160	msdc-0160	ADJ
fnp-3049	33	16	’s	’s	PART
fnp-3049	33	17	limited	limited	ADJ
fnp-3049	33	18	side	side	NOUN
fnp-3049	33	19	effects	effect	NOUN
fnp-3049	33	20	and	and	CCONJ
fnp-3049	33	21	its	its	PRON
fnp-3049	33	22	bioavailability	bioavailability	NOUN
fnp-3049	33	23	in	in	ADP
fnp-3049	33	24	brain	brain	NOUN
fnp-3049	33	25	,	,	PUNCT
fnp-3049	33	26	we	we	PRON
fnp-3049	33	27	previously	previously	ADV
fnp-3049	33	28	tested	test	VERB
fnp-3049	33	29	it	it	PRON
fnp-3049	33	30	in	in	ADP
fnp-3049	33	31	cell	cell	NOUN
fnp-3049	33	32	and	and	CCONJ
fnp-3049	33	33	animal	animal	NOUN
fnp-3049	33	34	models	model	NOUN
fnp-3049	33	35	of	of	ADP
fnp-3049	33	36	pd	pd	PROPN
fnp-3049	33	37	and	and	CCONJ
fnp-3049	33	38	found	find	VERB
fnp-3049	33	39	that	that	SCONJ
fnp-3049	33	40	msdc-0160	msdc-0160	NOUN
fnp-3049	33	41	is	be	AUX
fnp-3049	33	42	neuroprotective10	neuroprotective10	NOUN
fnp-3049	33	43	.	.	PUNCT
fnp-3049	34	1	specifically	specifically	ADV
fnp-3049	34	2	,	,	PUNCT
fnp-3049	34	3	msdc-0160	msdc-0160	ADJ
fnp-3049	34	4	protects	protect	VERB
fnp-3049	34	5	against	against	ADP
fnp-3049	34	6	dopaminergic	dopaminergic	ADJ
fnp-3049	34	7	cell	cell	NOUN
fnp-3049	34	8	loss	loss	NOUN
fnp-3049	34	9	in	in	ADP
fnp-3049	34	10	the	the	DET
fnp-3049	34	11	substantia	substantia	NOUN
fnp-3049	34	12	nigra	nigra	NOUN
fnp-3049	34	13	in	in	ADP
fnp-3049	34	14	neurotoxin	neurotoxin	NOUN
fnp-3049	34	15	-	-	PUNCT
fnp-3049	34	16	challenged	challenge	VERB
fnp-3049	34	17	mice	mouse	NOUN
fnp-3049	34	18	and	and	CCONJ
fnp-3049	34	19	in	in	ADP
fnp-3049	34	20	a	a	DET
fnp-3049	34	21	genetic	genetic	ADJ
fnp-3049	34	22	mouse	mouse	NOUN
fnp-3049	34	23	model	model	NOUN
fnp-3049	34	24	with	with	ADP
fnp-3049	34	25	hemizygous	hemizygous	ADJ
fnp-3049	34	26	loss	loss	NOUN
fnp-3049	34	27	of	of	ADP
fnp-3049	34	28	the	the	DET
fnp-3049	34	29	transcription	transcription	NOUN
fnp-3049	34	30	factor	factor	NOUN
fnp-3049	34	31	engrailed	engraile	VERB
fnp-3049	34	32	1	1	NUM
fnp-3049	34	33	(	(	PUNCT
fnp-3049	34	34	en1	en1	PROPN
fnp-3049	34	35	)	)	PUNCT
fnp-3049	34	36	,	,	PUNCT
fnp-3049	34	37	which	which	PRON
fnp-3049	34	38	is	be	AUX
fnp-3049	34	39	believed	believe	VERB
fnp-3049	34	40	to	to	PART
fnp-3049	34	41	entail	entail	VERB
fnp-3049	34	42	mitochondrial	mitochondrial	ADJ
fnp-3049	34	43	deficits11	deficits11	NOUN
fnp-3049	34	44	.	.	PUNCT
fnp-3049	35	1	we	we	PRON
fnp-3049	35	2	also	also	ADV
fnp-3049	35	3	observed	observe	VERB
fnp-3049	35	4	a	a	DET
fnp-3049	35	5	mitigation	mitigation	NOUN
fnp-3049	35	6	of	of	ADP
fnp-3049	35	7	neuron	neuron	NOUN
fnp-3049	35	8	death	death	NOUN
fnp-3049	35	9	of	of	ADP
fnp-3049	35	10	msdc-0160	msdc-0160	ADJ
fnp-3049	35	11	treatment	treatment	NOUN
fnp-3049	35	12	in	in	ADP
fnp-3049	35	13	caenorhabditis	caenorhabditis	ADJ
fnp-3049	35	14	elegans	elegan	NOUN
fnp-3049	35	15	(	(	PUNCT
fnp-3049	35	16	c.	c.	NOUN
fnp-3049	35	17	elegans	elegan	NOUN
fnp-3049	35	18	)	)	PUNCT
fnp-3049	35	19	in	in	ADP
fnp-3049	35	20	which	which	PRON
fnp-3049	35	21	we	we	PRON
fnp-3049	35	22	over	over	ADV
fnp-3049	35	23	-	-	PUNCT
fnp-3049	35	24	expressed	express	VERB
fnp-3049	35	25	αsyn	αsyn	NOUN
fnp-3049	35	26	.	.	PUNCT
fnp-3049	36	1	taken	take	VERB
fnp-3049	36	2	together	together	ADV
fnp-3049	36	3	,	,	PUNCT
fnp-3049	36	4	we	we	PRON
fnp-3049	36	5	hypothesized	hypothesize	VERB
fnp-3049	36	6	that	that	SCONJ
fnp-3049	36	7	the	the	DET
fnp-3049	36	8	beneficial	beneficial	ADJ
fnp-3049	36	9	effects	effect	NOUN
fnp-3049	36	10	of	of	ADP
fnp-3049	36	11	msdc-0160	msdc-0160	NOUN
fnp-3049	36	12	were	be	AUX
fnp-3049	36	13	due	due	ADJ
fnp-3049	36	14	to	to	ADP
fnp-3049	36	15	its	its	PRON
fnp-3049	36	16	anti	anti	ADJ
fnp-3049	36	17	-	-	ADJ
fnp-3049	36	18	inflammatory	inflammatory	ADJ
fnp-3049	36	19	effects	effect	NOUN
fnp-3049	36	20	and	and	CCONJ
fnp-3049	36	21	its	its	PRON
fnp-3049	36	22	ability	ability	NOUN
fnp-3049	36	23	to	to	PART
fnp-3049	36	24	normalize	normalize	VERB
fnp-3049	36	25	metabolic	metabolic	NOUN
fnp-3049	36	26	deficits	deficit	NOUN
fnp-3049	36	27	.	.	PUNCT
fnp-3049	37	1	the	the	DET
fnp-3049	37	2	effects	effect	NOUN
fnp-3049	37	3	of	of	ADP
fnp-3049	37	4	msdc-0160	msdc-0160	NOUN
fnp-3049	37	5	on	on	ADP
fnp-3049	37	6	αsyn	αsyn	ADJ
fnp-3049	37	7	aggregation	aggregation	NOUN
fnp-3049	37	8	in	in	ADP
fnp-3049	37	9	progressive	progressive	ADJ
fnp-3049	37	10	,	,	PUNCT
fnp-3049	37	11	chronic	chronic	ADJ
fnp-3049	37	12	pd	pd	NOUN
fnp-3049	37	13	models	model	NOUN
fnp-3049	37	14	have	have	AUX
fnp-3049	37	15	previously	previously	ADV
fnp-3049	37	16	not	not	PART
fnp-3049	37	17	been	be	AUX
fnp-3049	37	18	investigated	investigate	VERB
fnp-3049	37	19	.	.	PUNCT
fnp-3049	38	1	in	in	ADP
fnp-3049	38	2	this	this	DET
fnp-3049	38	3	study	study	NOUN
fnp-3049	38	4	,	,	PUNCT
fnp-3049	38	5	we	we	PRON
fnp-3049	38	6	therefore	therefore	ADV
fnp-3049	38	7	evaluated	evaluate	VERB
fnp-3049	38	8	msdc-0160	msdc-0160	NOUN
fnp-3049	38	9	in	in	ADP
fnp-3049	38	10	two	two	NUM
fnp-3049	38	11	different	different	ADJ
fnp-3049	38	12	α	α	NOUN
fnp-3049	38	13	-	-	PUNCT
fnp-3049	38	14	syn	syn	PROPN
fnp-3049	38	15	based	base	VERB
fnp-3049	38	16	rodent	rodent	NOUN
fnp-3049	38	17	models	model	NOUN
fnp-3049	38	18	of	of	ADP
fnp-3049	38	19	pd	pd	PROPN
fnp-3049	38	20	;	;	PUNCT
fnp-3049	38	21	1	1	X
fnp-3049	38	22	)	)	PUNCT
fnp-3049	38	23	a	a	DET
fnp-3049	38	24	rat	rat	NOUN
fnp-3049	38	25	model	model	NOUN
fnp-3049	38	26	with	with	ADP
fnp-3049	38	27	adeno	adeno	NOUN
fnp-3049	38	28	-	-	PUNCT
fnp-3049	38	29	associated	associate	VERB
fnp-3049	38	30	virus	virus	NOUN
fnp-3049	38	31	(	(	PUNCT
fnp-3049	38	32	aav	aav	NOUN
fnp-3049	38	33	)	)	PUNCT
fnp-3049	38	34	vector	vector	NOUN
fnp-3049	38	35	over	over	ADP
fnp-3049	38	36	-	-	PUNCT
fnp-3049	38	37	expression	expression	NOUN
fnp-3049	38	38	of	of	ADP
fnp-3049	38	39	human	human	ADJ
fnp-3049	38	40	αsyn	αsyn	NOUN
fnp-3049	38	41	and	and	CCONJ
fnp-3049	38	42	2	2	NUM
fnp-3049	38	43	)	)	PUNCT
fnp-3049	38	44	a	a	DET
fnp-3049	38	45	mouse	mouse	NOUN
fnp-3049	38	46	αsyn	αsyn	NOUN
fnp-3049	38	47	pre	pre	VERB
fnp-3049	38	48	-	-	ADJ
fnp-3049	38	49	formed	form	VERB
fnp-3049	38	50	fibril	fibril	ADJ
fnp-3049	38	51	(	(	PUNCT
fnp-3049	38	52	pff	pff	PROPN
fnp-3049	38	53	)	)	PUNCT
fnp-3049	38	54	seeding	seed	VERB
fnp-3049	38	55	model	model	NOUN
fnp-3049	38	56	.	.	PUNCT
fnp-3049	39	1	unexpectedly	unexpectedly	ADV
fnp-3049	39	2	,	,	PUNCT
fnp-3049	39	3	we	we	PRON
fnp-3049	39	4	found	find	VERB
fnp-3049	39	5	that	that	SCONJ
fnp-3049	39	6	msdc-0160	msdc-0160	NOUN
fnp-3049	39	7	increased	increase	VERB
fnp-3049	39	8	the	the	DET
fnp-3049	39	9	levels	level	NOUN
fnp-3049	39	10	of	of	ADP
fnp-3049	39	11	aggregated	aggregate	VERB
fnp-3049	39	12	αsyn	αsyn	NOUN
fnp-3049	39	13	in	in	ADP
fnp-3049	39	14	the	the	DET
fnp-3049	39	15	aav	aav	NOUN
fnp-3049	39	16	-	-	PUNCT
fnp-3049	39	17	overexpression	overexpression	NOUN
fnp-3049	39	18	model	model	NOUN
fnp-3049	39	19	,	,	PUNCT
fnp-3049	39	20	possibly	possibly	ADV
fnp-3049	39	21	via	via	ADP
fnp-3049	39	22	increased	increase	VERB
fnp-3049	39	23	oxidation	oxidation	NOUN
fnp-3049	39	24	of	of	ADP
fnp-3049	39	25	soluble	soluble	ADJ
fnp-3049	39	26	αsyn	αsyn	NOUN
fnp-3049	39	27	.	.	PUNCT
fnp-3049	40	1	in	in	ADP
fnp-3049	40	2	the	the	DET
fnp-3049	40	3	pff	pff	NOUN
fnp-3049	40	4	seeding	seeding	NOUN
fnp-3049	40	5	model	model	NOUN
fnp-3049	40	6	,	,	PUNCT
fnp-3049	40	7	msdc-0160	msdc-0160	PROPN
fnp-3049	40	8	also	also	ADV
fnp-3049	40	9	increased	increase	VERB
fnp-3049	40	10	αsyn	αsyn	ADJ
fnp-3049	40	11	burden	burden	NOUN
fnp-3049	40	12	transiently	transiently	ADV
fnp-3049	40	13	;	;	PUNCT
fnp-3049	40	14	a	a	DET
fnp-3049	40	15	significant	significant	ADJ
fnp-3049	40	16	difference	difference	NOUN
fnp-3049	40	17	between	between	ADP
fnp-3049	40	18	the	the	DET
fnp-3049	40	19	treatment	treatment	NOUN
fnp-3049	40	20	groups	group	NOUN
fnp-3049	40	21	was	be	AUX
fnp-3049	40	22	observed	observe	VERB
fnp-3049	40	23	five	five	NUM
fnp-3049	40	24	weeks	week	NOUN
fnp-3049	40	25	after	after	ADP
fnp-3049	40	26	pff	pff	PROPN
fnp-3049	40	27	injection	injection	NOUN
fnp-3049	40	28	,	,	PUNCT
fnp-3049	40	29	but	but	CCONJ
fnp-3049	40	30	it	it	PRON
fnp-3049	40	31	was	be	AUX
fnp-3049	40	32	not	not	PART
fnp-3049	40	33	present	present	ADJ
fnp-3049	40	34	at	at	ADP
fnp-3049	40	35	the	the	DET
fnp-3049	40	36	later	later	ADJ
fnp-3049	40	37	13	13	NUM
fnp-3049	40	38	-	-	PUNCT
fnp-3049	40	39	week	week	NOUN
fnp-3049	40	40	timepoint	timepoint	NOUN
fnp-3049	40	41	.	.	PUNCT
fnp-3049	41	1	we	we	PRON
fnp-3049	41	2	examined	examine	VERB
fnp-3049	41	3	both	both	DET
fnp-3049	41	4	models	model	NOUN
fnp-3049	41	5	further	far	ADV
fnp-3049	41	6	for	for	ADP
fnp-3049	41	7	inflammatory	inflammatory	ADJ
fnp-3049	41	8	and	and	CCONJ
fnp-3049	41	9	lysosomal	lysosomal	ADJ
fnp-3049	41	10	markers	marker	NOUN
fnp-3049	41	11	,	,	PUNCT
fnp-3049	41	12	and	and	CCONJ
fnp-3049	41	13	found	find	VERB
fnp-3049	41	14	them	they	PRON
fnp-3049	41	15	both	both	PRON
fnp-3049	41	16	to	to	PART
fnp-3049	41	17	be	be	AUX
fnp-3049	41	18	unaltered	unaltere	VERB
fnp-3049	41	19	,	,	PUNCT
fnp-3049	41	20	even	even	ADV
fnp-3049	41	21	in	in	ADP
fnp-3049	41	22	the	the	DET
fnp-3049	41	23	presence	presence	NOUN
fnp-3049	41	24	of	of	ADP
fnp-3049	41	25	robust	robust	ADJ
fnp-3049	41	26	αsyn	αsyn	ADJ
fnp-3049	41	27	pathology	pathology	NOUN
fnp-3049	41	28	.	.	PUNCT
fnp-3049	42	1	we	we	PRON
fnp-3049	42	2	conclude	conclude	VERB
fnp-3049	42	3	that	that	SCONJ
fnp-3049	42	4	while	while	SCONJ
fnp-3049	42	5	neuroprotective	neuroprotective	ADJ
fnp-3049	42	6	actions	action	NOUN
fnp-3049	42	7	of	of	ADP
fnp-3049	42	8	msdc-0160	msdc-0160	NOUN
fnp-3049	42	9	may	may	AUX
fnp-3049	42	10	occur	occur	VERB
fnp-3049	42	11	via	via	ADP
fnp-3049	42	12	restoring	restore	VERB
fnp-3049	42	13	inflammatory	inflammatory	ADJ
fnp-3049	42	14	and	and	CCONJ
fnp-3049	42	15	metabolic	metabolic	NOUN
fnp-3049	42	16	deficits	deficit	NOUN
fnp-3049	42	17	,	,	PUNCT
fnp-3049	42	18	we	we	PRON
fnp-3049	42	19	could	could	AUX
fnp-3049	42	20	not	not	PART
fnp-3049	42	21	demonstrate	demonstrate	VERB
fnp-3049	42	22	effects	effect	NOUN
fnp-3049	42	23	on	on	ADP
fnp-3049	42	24	protein	protein	NOUN
fnp-3049	42	25	aggregation	aggregation	NOUN
fnp-3049	42	26	or	or	CCONJ
fnp-3049	42	27	protein	protein	NOUN
fnp-3049	42	28	spreading	spread	VERB
fnp-3049	42	29	in	in	ADP
fnp-3049	42	30	these	these	DET
fnp-3049	42	31	rodent	rodent	ADJ
fnp-3049	42	32	models	model	NOUN
fnp-3049	42	33	of	of	ADP
fnp-3049	42	34	synucleinopathies	synucleinopathie	NOUN
fnp-3049	42	35	.	.	PUNCT
fnp-3049	43	1	methods	method	NOUN
fnp-3049	43	2	animals	animal	VERB
fnp-3049	43	3	twelve	twelve	NUM
fnp-3049	43	4	-	-	PUNCT
fnp-3049	43	5	week	week	NOUN
fnp-3049	43	6	-	-	PUNCT
fnp-3049	43	7	old	old	ADJ
fnp-3049	43	8	male	male	ADJ
fnp-3049	43	9	and	and	CCONJ
fnp-3049	43	10	female	female	ADJ
fnp-3049	43	11	c57bl/6j	c57bl/6j	PROPN
fnp-3049	43	12	wildtype	wildtype	NOUN
fnp-3049	43	13	(	(	PUNCT
fnp-3049	43	14	wt	wt	NOUN
fnp-3049	43	15	)	)	PUNCT
fnp-3049	43	16	mice	mouse	NOUN
fnp-3049	43	17	were	be	AUX
fnp-3049	43	18	sourced	source	VERB
fnp-3049	43	19	from	from	ADP
fnp-3049	43	20	the	the	DET
fnp-3049	43	21	jackson	jackson	PROPN
fnp-3049	43	22	laboratory	laboratory	PROPN
fnp-3049	43	23	.	.	PUNCT
fnp-3049	44	1	eight	eight	NUM
fnp-3049	44	2	-	-	PUNCT
fnp-3049	44	3	week	week	NOUN
fnp-3049	44	4	old	old	ADJ
fnp-3049	44	5	female	female	ADJ
fnp-3049	44	6	rats	rat	NOUN
fnp-3049	44	7	were	be	AUX
fnp-3049	44	8	obtained	obtain	VERB
fnp-3049	44	9	from	from	ADP
fnp-3049	44	10	charles	charles	PROPN
fnp-3049	44	11	river	river	PROPN
fnp-3049	44	12	.	.	PUNCT
fnp-3049	45	1	animals	animal	NOUN
fnp-3049	45	2	were	be	AUX
fnp-3049	45	3	housed	house	VERB
fnp-3049	45	4	with	with	ADP
fnp-3049	45	5	a	a	DET
fnp-3049	45	6	maximum	maximum	NOUN
fnp-3049	45	7	of	of	ADP
fnp-3049	45	8	four	four	NUM
fnp-3049	45	9	mice	mouse	NOUN
fnp-3049	45	10	or	or	CCONJ
fnp-3049	45	11	two	two	NUM
fnp-3049	45	12	rats	rat	NOUN
fnp-3049	45	13	per	per	ADP
fnp-3049	45	14	cage	cage	NOUN
fnp-3049	45	15	under	under	ADP
fnp-3049	45	16	12	12	NUM
fnp-3049	45	17	-	-	PUNCT
fnp-3049	45	18	h	h	NOUN
fnp-3049	45	19	light/12	light/12	ADJ
fnp-3049	45	20	-	-	ADJ
fnp-3049	45	21	h	h	ADJ
fnp-3049	45	22	dark	dark	ADJ
fnp-3049	45	23	cycles	cycle	NOUN
fnp-3049	45	24	with	with	ADP
fnp-3049	45	25	free	free	ADJ
fnp-3049	45	26	access	access	NOUN
fnp-3049	45	27	to	to	ADP
fnp-3049	45	28	food	food	NOUN
fnp-3049	45	29	and	and	CCONJ
fnp-3049	45	30	water	water	NOUN
fnp-3049	45	31	.	.	PUNCT
fnp-3049	46	1	for	for	ADP
fnp-3049	46	2	a	a	DET
fnp-3049	46	3	direct	direct	ADJ
fnp-3049	46	4	comparison	comparison	NOUN
fnp-3049	46	5	of	of	ADP
fnp-3049	46	6	msdc-0160	msdc-0160	ADJ
fnp-3049	46	7	and	and	CCONJ
fnp-3049	46	8	pioglitazone	pioglitazone	NOUN
fnp-3049	46	9	biodistribution	biodistribution	NOUN
fnp-3049	46	10	of	of	ADP
fnp-3049	46	11	their	their	PRON
fnp-3049	46	12	metabolites	metabolite	NOUN
fnp-3049	46	13	in	in	ADP
fnp-3049	46	14	vivo	vivo	NOUN
fnp-3049	46	15	,	,	PUNCT
fnp-3049	46	16	msdc-0160	msdc-0160	NOUN
fnp-3049	46	17	and	and	CCONJ
fnp-3049	46	18	pioglitazone	pioglitazone	NOUN
fnp-3049	46	19	were	be	AUX
fnp-3049	46	20	administered	administer	VERB
fnp-3049	46	21	via	via	ADP
fnp-3049	46	22	oral	oral	ADJ
fnp-3049	46	23	gavage	gavage	NOUN
fnp-3049	46	24	for	for	ADP
fnp-3049	46	25	3	3	NUM
fnp-3049	46	26	days	day	NOUN
fnp-3049	46	27	for	for	ADP
fnp-3049	46	28	a	a	DET
fnp-3049	46	29	dose	dose	NOUN
fnp-3049	46	30	of	of	ADP
fnp-3049	46	31	30mg	30mg	NUM
fnp-3049	46	32	/	/	SYM
fnp-3049	46	33	kg	kg	PROPN
fnp-3049	46	34	/	/	SYM
fnp-3049	46	35	day	day	NOUN
fnp-3049	46	36	.	.	PUNCT
fnp-3049	47	1	collection	collection	NOUN
fnp-3049	47	2	of	of	ADP
fnp-3049	47	3	plasma	plasma	NOUN
fnp-3049	47	4	,	,	PUNCT
fnp-3049	47	5	csf	csf	NOUN
fnp-3049	47	6	and	and	CCONJ
fnp-3049	47	7	brain	brain	NOUN
fnp-3049	47	8	mitochondria	mitochondria	NOUN
fnp-3049	47	9	was	be	AUX
fnp-3049	47	10	performed	perform	VERB
fnp-3049	47	11	after	after	ADP
fnp-3049	47	12	day	day	NOUN
fnp-3049	47	13	3	3	NUM
fnp-3049	47	14	.	.	PUNCT
fnp-3049	48	1	for	for	ADP
fnp-3049	48	2	the	the	DET
fnp-3049	48	3	chronic	chronic	ADJ
fnp-3049	48	4	administration	administration	NOUN
fnp-3049	48	5	of	of	ADP
fnp-3049	48	6	msdc-0160	msdc-0160	ADJ
fnp-3049	48	7	,	,	PUNCT
fnp-3049	48	8	mice	mouse	NOUN
fnp-3049	48	9	and	and	CCONJ
fnp-3049	48	10	rats	rat	NOUN
fnp-3049	48	11	were	be	AUX
fnp-3049	48	12	fed	feed	VERB
fnp-3049	48	13	a	a	DET
fnp-3049	48	14	diet	diet	NOUN
fnp-3049	48	15	of	of	ADP
fnp-3049	48	16	chow	chow	PROPN
fnp-3049	48	17	formulated	formulate	VERB
fnp-3049	48	18	to	to	PART
fnp-3049	48	19	deliver	deliver	VERB
fnp-3049	48	20	msdc-0160	msdc-0160	ADJ
fnp-3049	48	21	(	(	PUNCT
fnp-3049	48	22	30	30	NUM
fnp-3049	48	23	mg	mg	NUM
fnp-3049	48	24	/	/	SYM
fnp-3049	48	25	kg	kg	NOUN
fnp-3049	48	26	)	)	PUNCT
fnp-3049	48	27	or	or	CCONJ
fnp-3049	48	28	control	control	PROPN
fnp-3049	48	29	chow	chow	PROPN
fnp-3049	48	30	starting	start	VERB
fnp-3049	48	31	at	at	ADP
fnp-3049	48	32	1	1	NUM
fnp-3049	48	33	week	week	NOUN
fnp-3049	48	34	after	after	ADP
fnp-3049	48	35	stereotactic	stereotactic	ADJ
fnp-3049	48	36	surgery	surgery	NOUN
fnp-3049	48	37	.	.	PUNCT
fnp-3049	49	1	mice	mouse	NOUN
fnp-3049	49	2	were	be	AUX
fnp-3049	49	3	euthanized	euthanize	VERB
fnp-3049	49	4	at	at	ADP
fnp-3049	49	5	two	two	NUM
fnp-3049	49	6	different	different	ADJ
fnp-3049	49	7	time	time	NOUN
fnp-3049	49	8	points	point	NOUN
fnp-3049	49	9	:	:	PUNCT
fnp-3049	49	10	one	one	NUM
fnp-3049	49	11	and	and	CCONJ
fnp-3049	49	12	three	three	NUM
fnp-3049	49	13	months	month	NOUN
fnp-3049	49	14	after	after	ADP
fnp-3049	49	15	pbs	pbs	PROPN
fnp-3049	49	16	/	/	SYM
fnp-3049	49	17	pff	pff	PROPN
fnp-3049	49	18	injections	injection	NOUN
fnp-3049	49	19	.	.	PUNCT
fnp-3049	50	1	rat	rat	NOUN
fnp-3049	50	2	were	be	AUX
fnp-3049	50	3	euthanized	euthanize	VERB
fnp-3049	50	4	four	four	NUM
fnp-3049	50	5	months	month	NOUN
fnp-3049	50	6	after	after	ADP
fnp-3049	50	7	viral	viral	ADJ
fnp-3049	50	8	transduction	transduction	NOUN
fnp-3049	50	9	.	.	PUNCT
fnp-3049	51	1	the	the	DET
fnp-3049	51	2	housing	housing	NOUN
fnp-3049	51	3	of	of	ADP
fnp-3049	51	4	animals	animal	NOUN
fnp-3049	51	5	and	and	CCONJ
fnp-3049	51	6	all	all	DET
fnp-3049	51	7	procedures	procedure	NOUN
fnp-3049	51	8	were	be	AUX
fnp-3049	51	9	performed	perform	VERB
fnp-3049	51	10	in	in	ADP
fnp-3049	51	11	accordance	accordance	NOUN
fnp-3049	51	12	with	with	ADP
fnp-3049	51	13	the	the	DET
fnp-3049	51	14	guide	guide	NOUN
fnp-3049	51	15	for	for	ADP
fnp-3049	51	16	the	the	DET
fnp-3049	51	17	care	care	NOUN
fnp-3049	51	18	and	and	CCONJ
fnp-3049	51	19	use	use	NOUN
fnp-3049	51	20	of	of	ADP
fnp-3049	51	21	laboratory	laboratory	NOUN
fnp-3049	51	22	animals	animal	NOUN
fnp-3049	51	23	(	(	PUNCT
fnp-3049	51	24	united	united	PROPN
fnp-3049	51	25	states	states	PROPN
fnp-3049	51	26	national	national	PROPN
fnp-3049	51	27	institutes	institutes	PROPN
fnp-3049	51	28	of	of	ADP
fnp-3049	51	29	health	health	NOUN
fnp-3049	51	30	)	)	PUNCT
fnp-3049	51	31	and	and	CCONJ
fnp-3049	51	32	were	be	AUX
fnp-3049	51	33	approved	approve	VERB
fnp-3049	51	34	by	by	ADP
fnp-3049	51	35	the	the	DET
fnp-3049	51	36	van	van	PROPN
fnp-3049	51	37	andel	andel	PROPN
fnp-3049	51	38	research	research	PROPN
fnp-3049	51	39	institute	institute	PROPN
fnp-3049	51	40	's	's	PART
fnp-3049	51	41	animal	animal	NOUN
fnp-3049	51	42	care	care	NOUN
fnp-3049	51	43	and	and	CCONJ
fnp-3049	51	44	use	use	NOUN
fnp-3049	51	45	committee	committee	NOUN
fnp-3049	51	46	.	.	PUNCT
fnp-3049	52	1	pff	pff	PROPN
fnp-3049	52	2	production	production	PROPN
fnp-3049	52	3	and	and	CCONJ
fnp-3049	52	4	ob	ob	NOUN
fnp-3049	52	5	injections	injection	NOUN
fnp-3049	52	6	mouse	mouse	NOUN
fnp-3049	52	7	αsyn	αsyn	ADJ
fnp-3049	52	8	pffs	pff	NOUN
fnp-3049	52	9	were	be	AUX
fnp-3049	52	10	produced	produce	VERB
fnp-3049	52	11	as	as	ADP
fnp-3049	52	12	described	describe	VERB
fnp-3049	52	13	previously12	previously12	PROPN
fnp-3049	52	14	.	.	PUNCT
fnp-3049	53	1	before	before	ADP
fnp-3049	53	2	surgery	surgery	NOUN
fnp-3049	53	3	,	,	PUNCT
fnp-3049	53	4	pffs	pff	NOUN
fnp-3049	53	5	were	be	AUX
fnp-3049	53	6	prepared	prepare	VERB
fnp-3049	53	7	by	by	ADP
fnp-3049	53	8	the	the	DET
fnp-3049	53	9	sonication	sonication	NOUN
fnp-3049	53	10	of	of	ADP
fnp-3049	53	11	αsyn	αsyn	ADJ
fnp-3049	53	12	aggregates	aggregate	NOUN
fnp-3049	53	13	in	in	ADP
fnp-3049	53	14	a	a	DET
fnp-3049	53	15	water	water	NOUN
fnp-3049	53	16	-	-	PUNCT
fnp-3049	53	17	bath	bath	NOUN
fnp-3049	53	18	cup	cup	NOUN
fnp-3049	53	19	-	-	PUNCT
fnp-3049	53	20	horn	horn	NOUN
fnp-3049	53	21	sonicator	sonicator	NOUN
fnp-3049	53	22	for	for	ADP
fnp-3049	53	23	four	four	NUM
fnp-3049	53	24	min	min	NOUN
fnp-3049	53	25	(	(	PUNCT
fnp-3049	53	26	qsonica	qsonica	NOUN
fnp-3049	53	27	,	,	PUNCT
fnp-3049	53	28	q700	q700	PROPN
fnp-3049	53	29	sonicator	sonicator	NOUN
fnp-3049	53	30	,	,	PUNCT
fnp-3049	53	31	50	50	NUM
fnp-3049	53	32	%	%	NOUN
fnp-3049	53	33	power	power	NOUN
fnp-3049	53	34	,	,	PUNCT
fnp-3049	53	35	120	120	NUM
fnp-3049	53	36	pulses	pulse	NOUN
fnp-3049	53	37	1	1	NUM
fnp-3049	53	38	s	s	VERB
fnp-3049	53	39	on	on	ADV
fnp-3049	53	40	,	,	PUNCT
fnp-3049	53	41	1	1	NUM
fnp-3049	53	42	s	s	VERB
fnp-3049	53	43	off	off	ADV
fnp-3049	53	44	)	)	PUNCT
fnp-3049	53	45	.	.	PUNCT
fnp-3049	54	1	mice	mouse	NOUN
fnp-3049	54	2	were	be	AUX
fnp-3049	54	3	anesthetized	anesthetize	VERB
fnp-3049	54	4	with	with	ADP
fnp-3049	54	5	isoflurane	isoflurane	NOUN
fnp-3049	54	6	/	/	SYM
fnp-3049	54	7	oxygen	oxygen	NOUN
fnp-3049	54	8	and	and	CCONJ
fnp-3049	54	9	injected	inject	VERB
fnp-3049	54	10	unilaterally	unilaterally	ADV
fnp-3049	54	11	in	in	ADP
fnp-3049	54	12	the	the	DET
fnp-3049	54	13	right	right	ADJ
fnp-3049	54	14	olfactory	olfactory	NOUN
fnp-3049	54	15	bulb	bulb	NOUN
fnp-3049	54	16	with	with	ADP
fnp-3049	54	17	either	either	DET
fnp-3049	54	18	0.8	0.8	NUM
fnp-3049	54	19	μl	μl	NUM
fnp-3049	54	20	of	of	ADP
fnp-3049	54	21	pff	pff	PROPN
fnp-3049	54	22	(	(	PUNCT
fnp-3049	54	23	5	5	NUM
fnp-3049	54	24	μg	μg	PROPN
fnp-3049	54	25	/	/	SYM
fnp-3049	54	26	μl	μl	NUM
fnp-3049	54	27	;	;	PUNCT
fnp-3049	54	28	n=36	n=36	PROPN
fnp-3049	54	29	,	,	PUNCT
fnp-3049	54	30	18	18	NUM
fnp-3049	54	31	females	female	NOUN
fnp-3049	54	32	/	/	SYM
fnp-3049	54	33	males	male	NOUN
fnp-3049	54	34	)	)	PUNCT
fnp-3049	54	35	or	or	CCONJ
fnp-3049	54	36	0.8	0.8	NUM
fnp-3049	54	37	μl	μl	NUM
fnp-3049	54	38	of	of	ADP
fnp-3049	54	39	pbs	pbs	PROPN
fnp-3049	54	40	as	as	ADP
fnp-3049	54	41	a	a	DET
fnp-3049	54	42	control	control	NOUN
fnp-3049	54	43	(	(	PUNCT
fnp-3049	54	44	n=36	n=36	PROPN
fnp-3049	54	45	,	,	PUNCT
fnp-3049	54	46	18	18	NUM
fnp-3049	54	47	females	female	NOUN
fnp-3049	54	48	/	/	SYM
fnp-3049	54	49	males	male	NOUN
fnp-3049	54	50	)	)	PUNCT
fnp-3049	54	51	.	.	PUNCT
fnp-3049	55	1	coordinates	coordinate	NOUN
fnp-3049	55	2	from	from	ADP
fnp-3049	55	3	bregma	bregma	NOUN
fnp-3049	55	4	:	:	PUNCT
fnp-3049	55	5	ap	ap	ADJ
fnp-3049	55	6	:	:	PUNCT
fnp-3049	55	7	+	+	NUM
fnp-3049	55	8	5.4	5.4	NUM
fnp-3049	55	9	mm	mm	NOUN
fnp-3049	55	10	;	;	PUNCT
fnp-3049	55	11	ml	ml	ADP
fnp-3049	55	12	:	:	PUNCT
fnp-3049	55	13	+	+	X
fnp-3049	55	14	/0.75	/0.75	PROPN
fnp-3049	55	15	mm	mm	PROPN
fnp-3049	55	16	and	and	CCONJ
fnp-3049	55	17	dv	dv	PROPN
fnp-3049	55	18	:	:	PUNCT
fnp-3049	55	19	1.0	1.0	NUM
fnp-3049	55	20	mm	mm	NOUN
fnp-3049	55	21	from	from	ADP
fnp-3049	55	22	dura	dura	PROPN
fnp-3049	55	23	.	.	PUNCT
fnp-3049	56	1	injections	injection	NOUN
fnp-3049	56	2	were	be	AUX
fnp-3049	56	3	made	make	VERB
fnp-3049	56	4	at	at	ADP
fnp-3049	56	5	a	a	DET
fnp-3049	56	6	rate	rate	NOUN
fnp-3049	56	7	of	of	ADP
fnp-3049	56	8	0.2	0.2	NUM
fnp-3049	56	9	μl	μl	NOUN
fnp-3049	56	10	/	/	SYM
fnp-3049	56	11	min	min	NOUN
fnp-3049	56	12	using	use	VERB
fnp-3049	56	13	a	a	DET
fnp-3049	56	14	glass	glass	NOUN
fnp-3049	56	15	capillary	capillary	ADJ
fnp-3049	56	16	attached	attach	VERB
fnp-3049	56	17	to	to	ADP
fnp-3049	56	18	a	a	DET
fnp-3049	56	19	10	10	NUM
fnp-3049	56	20	μl	μl	PROPN
fnp-3049	56	21	hamilton	hamilton	PROPN
fnp-3049	56	22	syringe	syringe	PROPN
fnp-3049	56	23	.	.	PUNCT
fnp-3049	57	1	after	after	ADP
fnp-3049	57	2	injection	injection	NOUN
fnp-3049	57	3	,	,	PUNCT
fnp-3049	57	4	the	the	DET
fnp-3049	57	5	capillary	capillary	ADJ
fnp-3049	57	6	was	be	AUX
fnp-3049	57	7	left	leave	VERB
fnp-3049	57	8	in	in	ADP
fnp-3049	57	9	place	place	NOUN
fnp-3049	57	10	for	for	ADP
fnp-3049	57	11	three	three	NUM
fnp-3049	57	12	min	min	NOUN
fnp-3049	57	13	,	,	PUNCT
fnp-3049	57	14	before	before	ADP
fnp-3049	57	15	being	be	AUX
fnp-3049	57	16	slowly	slowly	ADV
fnp-3049	57	17	removed	remove	VERB
fnp-3049	57	18	.	.	PUNCT
fnp-3049	58	1	viral	viral	ADJ
fnp-3049	58	2	vector	vector	NOUN
fnp-3049	58	3	production	production	NOUN
fnp-3049	58	4	and	and	CCONJ
fnp-3049	58	5	nigral	nigral	ADJ
fnp-3049	58	6	surgeries	surgery	NOUN
fnp-3049	58	7	raav2/5	raav2/5	NOUN
fnp-3049	58	8	-	-	PUNCT
fnp-3049	58	9	cmvsyn	cmvsyn	ADJ
fnp-3049	58	10	-	-	PUNCT
fnp-3049	58	11	human	human	ADJ
fnp-3049	58	12	-	-	PUNCT
fnp-3049	58	13	αsyn	αsyn	NOUN
fnp-3049	58	14	and	and	CCONJ
fnp-3049	58	15	raav2/5	raav2/5	NOUN
fnp-3049	58	16	-	-	PUNCT
fnp-3049	58	17	cmvsyn	cmvsyn	ADJ
fnp-3049	58	18	-	-	PUNCT
fnp-3049	58	19	gfp	gfp	NOUN
fnp-3049	58	20	production	production	NOUN
fnp-3049	58	21	was	be	AUX
fnp-3049	58	22	performed	perform	VERB
fnp-3049	58	23	as	as	ADP
fnp-3049	58	24	described	describe	VERB
fnp-3049	58	25	previously13	previously13	NOUN
fnp-3049	58	26	.	.	PUNCT
fnp-3049	59	1	genome	genome	NOUN
fnp-3049	59	2	copies	copy	NOUN
fnp-3049	59	3	were	be	AUX
fnp-3049	59	4	determined	determine	VERB
fnp-3049	59	5	via	via	ADP
fnp-3049	59	6	qpcr	qpcr	ADJ
fnp-3049	59	7	and	and	CCONJ
fnp-3049	59	8	two	two	NUM
fnp-3049	59	9	viral	viral	ADJ
fnp-3049	59	10	vector	vector	NOUN
fnp-3049	59	11	titers	titer	NOUN
fnp-3049	59	12	were	be	AUX
fnp-3049	59	13	used	use	VERB
fnp-3049	59	14	for	for	ADP
fnp-3049	59	15	injection	injection	NOUN
fnp-3049	59	16	into	into	ADP
fnp-3049	59	17	the	the	DET
fnp-3049	59	18	rat	rat	NOUN
fnp-3049	59	19	sn	sn	PROPN
fnp-3049	59	20	.	.	PUNCT
fnp-3049	60	1	nigral	nigral	ADJ
fnp-3049	60	2	injections	injection	NOUN
fnp-3049	60	3	were	be	AUX
fnp-3049	60	4	performed	perform	VERB
fnp-3049	60	5	under	under	ADP
fnp-3049	60	6	general	general	ADJ
fnp-3049	60	7	anesthesia	anesthesia	NOUN
fnp-3049	60	8	using	use	VERB
fnp-3049	60	9	an	an	DET
fnp-3049	60	10	isoflurane	isoflurane	NOUN
fnp-3049	60	11	/	/	SYM
fnp-3049	60	12	oxygen	oxygen	NOUN
fnp-3049	60	13	mixture	mixture	NOUN
fnp-3049	60	14	.	.	PUNCT
fnp-3049	61	1	for	for	ADP
fnp-3049	61	2	the	the	DET
fnp-3049	61	3	αsyn	αsyn	PROPN
fnp-3049	61	4	low	low	PROPN
fnp-3049	61	5	dose	dose	PROPN
fnp-3049	61	6	and	and	CCONJ
fnp-3049	61	7	αsyn	αsyn	PROPN
fnp-3049	61	8	high	high	PROPN
fnp-3049	61	9	dose	dose	VERB
fnp-3049	61	10	a	a	DET
fnp-3049	61	11	total	total	NOUN
fnp-3049	61	12	of	of	ADP
fnp-3049	61	13	1.2x1011gc	1.2x1011gc	NUM
fnp-3049	61	14	and	and	CCONJ
fnp-3049	61	15	2.5x1011gc	2.5x1011gc	NUM
fnp-3049	61	16	were	be	AUX
fnp-3049	61	17	injected	inject	VERB
fnp-3049	61	18	,	,	PUNCT
fnp-3049	61	19	respectively	respectively	ADV
fnp-3049	61	20	.	.	PUNCT
fnp-3049	62	1	as	as	ADP
fnp-3049	62	2	a	a	DET
fnp-3049	62	3	control	control	NOUN
fnp-3049	62	4	,	,	PUNCT
fnp-3049	62	5	3x1011gc	3x1011gc	NUM
fnp-3049	62	6	of	of	ADP
fnp-3049	62	7	gfp	gfp	PROPN
fnp-3049	62	8	expressing	express	VERB
fnp-3049	62	9	viral	viral	ADJ
fnp-3049	62	10	vector	vector	NOUN
fnp-3049	62	11	or	or	CCONJ
fnp-3049	62	12	pbs	pbs	NOUN
fnp-3049	62	13	were	be	AUX
fnp-3049	62	14	injected	inject	VERB
fnp-3049	62	15	.	.	PUNCT
fnp-3049	63	1	coordinates	coordinate	NOUN
fnp-3049	63	2	from	from	ADP
fnp-3049	63	3	bregma	bregma	NOUN
fnp-3049	63	4	:	:	PUNCT
fnp-3049	63	5	ap	ap	PROPN
fnp-3049	63	6	:	:	PUNCT
fnp-3049	63	7	5.3	5.3	NUM
fnp-3049	63	8	mm	mm	NOUN
fnp-3049	63	9	,	,	PUNCT
fnp-3049	63	10	ml	ml	ADP
fnp-3049	63	11	:	:	PUNCT
fnp-3049	63	12	2.0	2.0	NUM
fnp-3049	63	13	mm	mm	NOUN
fnp-3049	63	14	and	and	CCONJ
fnp-3049	63	15	dv	dv	PROPN
fnp-3049	63	16	:	:	PUNCT
fnp-3049	63	17	7.2	7.2	NUM
fnp-3049	63	18	mm	mm	NOUN
fnp-3049	63	19	measured	measure	VERB
fnp-3049	63	20	from	from	ADP
fnp-3049	63	21	dura14	dura14	NOUN
fnp-3049	63	22	.	.	PUNCT
fnp-3049	64	1	a	a	DET
fnp-3049	64	2	volume	volume	NOUN
fnp-3049	64	3	of	of	ADP
fnp-3049	64	4	3	3	NUM
fnp-3049	64	5	μl	μl	ADP
fnp-3049	64	6	of	of	ADP
fnp-3049	64	7	viral	viral	ADJ
fnp-3049	64	8	vector	vector	NOUN
fnp-3049	64	9	was	be	AUX
fnp-3049	64	10	infused	infuse	VERB
fnp-3049	64	11	at	at	ADP
fnp-3049	64	12	a	a	DET
fnp-3049	64	13	rate	rate	NOUN
fnp-3049	64	14	of	of	ADP
fnp-3049	64	15	0.25	0.25	NUM
fnp-3049	64	16	μl	μl	NOUN
fnp-3049	64	17	/	/	SYM
fnp-3049	64	18	min	min	NOUN
fnp-3049	64	19	using	use	VERB
fnp-3049	64	20	a	a	DET
fnp-3049	64	21	30	30	NUM
fnp-3049	64	22	g	g	NOUN
fnp-3049	64	23	needle	needle	NOUN
fnp-3049	64	24	and	and	CCONJ
fnp-3049	64	25	10	10	NUM
fnp-3049	64	26	μl	μl	PROPN
fnp-3049	64	27	hamilton	hamilton	PROPN
fnp-3049	64	28	syringe	syringe	PROPN
fnp-3049	64	29	.	.	PUNCT
fnp-3049	65	1	msdc-0160	msdc-0160	ADJ
fnp-3049	65	2	metabolite	metabolite	NOUN
fnp-3049	65	3	analysis	analysis	NOUN
fnp-3049	65	4	mice	mouse	NOUN
fnp-3049	65	5	and	and	CCONJ
fnp-3049	65	6	rats	rat	NOUN
fnp-3049	65	7	were	be	AUX
fnp-3049	65	8	allowed	allow	VERB
fnp-3049	65	9	free	free	ADJ
fnp-3049	65	10	access	access	NOUN
fnp-3049	65	11	to	to	ADP
fnp-3049	65	12	chow	chow	PROPN
fnp-3049	65	13	containing	contain	VERB
fnp-3049	65	14	either	either	CCONJ
fnp-3049	65	15	msdc-0160	msdc-0160	ADJ
fnp-3049	65	16	(	(	PUNCT
fnp-3049	65	17	30	30	NUM
fnp-3049	65	18	mg	mg	NUM
fnp-3049	65	19	/	/	SYM
fnp-3049	65	20	kg	kg	NOUN
fnp-3049	65	21	)	)	PUNCT
fnp-3049	65	22	or	or	CCONJ
fnp-3049	65	23	placebo	placebo	NOUN
fnp-3049	65	24	for	for	ADP
fnp-3049	65	25	up	up	ADP
fnp-3049	65	26	to	to	PART
fnp-3049	65	27	four	four	NUM
fnp-3049	65	28	months	month	NOUN
fnp-3049	65	29	.	.	PUNCT
fnp-3049	66	1	for	for	ADP
fnp-3049	66	2	mice	mouse	NOUN
fnp-3049	66	3	,	,	PUNCT
fnp-3049	66	4	whole	whole	ADJ
fnp-3049	66	5	blood	blood	NOUN
fnp-3049	66	6	was	be	AUX
fnp-3049	66	7	collected	collect	VERB
fnp-3049	66	8	five	five	NUM
fnp-3049	66	9	and	and	CCONJ
fnp-3049	66	10	13	13	NUM
fnp-3049	66	11	weeks	week	NOUN
fnp-3049	66	12	post	post	ADJ
fnp-3049	66	13	-	-	NOUN
fnp-3049	66	14	surgery	surgery	NOUN
fnp-3049	66	15	from	from	ADP
fnp-3049	66	16	the	the	DET
fnp-3049	66	17	submandibular	submandibular	NOUN
fnp-3049	66	18	vein	vein	NOUN
fnp-3049	66	19	in	in	ADP
fnp-3049	66	20	6	6	NUM
fnp-3049	66	21	ml	ml	NOUN
fnp-3049	66	22	bd	bd	PROPN
fnp-3049	66	23	heparinized	heparinize	VERB
fnp-3049	66	24	tubes	tube	NOUN
fnp-3049	66	25	.	.	PUNCT
fnp-3049	67	1	for	for	ADP
fnp-3049	67	2	rats	rat	NOUN
fnp-3049	67	3	,	,	PUNCT
fnp-3049	67	4	whole	whole	ADJ
fnp-3049	67	5	blood	blood	NOUN
fnp-3049	67	6	was	be	AUX
fnp-3049	67	7	collected	collect	VERB
fnp-3049	67	8	in	in	ADP
fnp-3049	67	9	identical	identical	ADJ
fnp-3049	67	10	tubes	tube	NOUN
fnp-3049	67	11	via	via	ADP
fnp-3049	67	12	cardiac	cardiac	ADJ
fnp-3049	67	13	puncture	puncture	NOUN
fnp-3049	67	14	four	four	NUM
fnp-3049	67	15	months	month	NOUN
fnp-3049	67	16	after	after	ADP
fnp-3049	67	17	viral	viral	ADJ
fnp-3049	67	18	vector	vector	NOUN
fnp-3049	67	19	injection	injection	NOUN
fnp-3049	67	20	.	.	PUNCT
fnp-3049	68	1	the	the	DET
fnp-3049	68	2	samples	sample	NOUN
fnp-3049	68	3	were	be	AUX
fnp-3049	68	4	centrifuged	centrifuge	VERB
fnp-3049	68	5	for	for	ADP
fnp-3049	68	6	15	15	NUM
fnp-3049	68	7	min	min	NOUN
fnp-3049	68	8	at	at	ADP
fnp-3049	68	9	4	4	NUM
fnp-3049	68	10	°	°	ADP
fnp-3049	68	11	c	c	NOUN
fnp-3049	68	12	(	(	PUNCT
fnp-3049	68	13	2000	2000	NUM
fnp-3049	68	14	x	x	SYM
fnp-3049	68	15	g	g	NOUN
fnp-3049	68	16	)	)	PUNCT
fnp-3049	68	17	,	,	PUNCT
fnp-3049	68	18	followed	follow	VERB
fnp-3049	68	19	by	by	ADP
fnp-3049	68	20	collection	collection	NOUN
fnp-3049	68	21	of	of	ADP
fnp-3049	68	22	the	the	DET
fnp-3049	68	23	supernatant	supernatant	NOUN
fnp-3049	68	24	(	(	PUNCT
fnp-3049	68	25	plasma	plasma	NOUN
fnp-3049	68	26	)	)	PUNCT
fnp-3049	68	27	which	which	PRON
fnp-3049	68	28	was	be	AUX
fnp-3049	68	29	snap	snap	ADJ
fnp-3049	68	30	frozen	frozen	ADJ
fnp-3049	68	31	and	and	CCONJ
fnp-3049	68	32	stored	store	VERB
fnp-3049	68	33	at	at	ADP
fnp-3049	68	34	-80	-80	NOUN
fnp-3049	68	35	°	°	NOUN
fnp-3049	68	36	c	c	NOUN
fnp-3049	68	37	.	.	PUNCT
fnp-3049	69	1	for	for	ADP
fnp-3049	69	2	collection	collection	NOUN
fnp-3049	69	3	of	of	ADP
fnp-3049	69	4	brain	brain	NOUN
fnp-3049	69	5	mitochondria	mitochondria	NOUN
fnp-3049	69	6	,	,	PUNCT
fnp-3049	69	7	brain	brain	NOUN
fnp-3049	69	8	was	be	AUX
fnp-3049	69	9	isolated	isolate	VERB
fnp-3049	69	10	and	and	CCONJ
fnp-3049	69	11	homogenized	homogenize	VERB
fnp-3049	69	12	via	via	ADP
fnp-3049	69	13	dounce	dounce	NOUN
fnp-3049	69	14	homogenization	homogenization	NOUN
fnp-3049	69	15	in	in	ADP
fnp-3049	69	16	a	a	DET
fnp-3049	69	17	sucrose	sucrose	ADJ
fnp-3049	69	18	homogenization	homogenization	NOUN
fnp-3049	69	19	buffer	buffer	NOUN
fnp-3049	69	20	(	(	PUNCT
fnp-3049	69	21	225	225	NUM
fnp-3049	69	22	mm	mm	NOUN
fnp-3049	69	23	sucrose	sucrose	NOUN
fnp-3049	69	24	,	,	PUNCT
fnp-3049	69	25	6	6	NUM
fnp-3049	69	26	mm	mm	NOUN
fnp-3049	69	27	k2hpo4	k2hpo4	PROPN
fnp-3049	69	28	,	,	PUNCT
fnp-3049	69	29	5	5	NUM
fnp-3049	69	30	mm	mm	NOUN
fnp-3049	69	31	mgcl2	mgcl2	PROPN
fnp-3049	69	32	,	,	PUNCT
fnp-3049	69	33	20	20	NUM
fnp-3049	69	34	mm	mm	NOUN
fnp-3049	69	35	kcl	kcl	NOUN
fnp-3049	69	36	and	and	CCONJ
fnp-3049	69	37	2	2	NUM
fnp-3049	69	38	mm	mm	NOUN
fnp-3049	69	39	egta	egta	PROPN
fnp-3049	69	40	)	)	PUNCT
fnp-3049	69	41	.	.	PUNCT
fnp-3049	70	1	samples	sample	NOUN
fnp-3049	70	2	were	be	AUX
fnp-3049	70	3	centrifuged	centrifuge	VERB
fnp-3049	70	4	at	at	ADP
fnp-3049	70	5	750	750	NUM
fnp-3049	70	6	g	g	NOUN
fnp-3049	70	7	to	to	PART
fnp-3049	70	8	remove	remove	VERB
fnp-3049	70	9	cell	cell	NOUN
fnp-3049	70	10	debris	debris	NOUN
fnp-3049	70	11	followed	follow	VERB
fnp-3049	70	12	by	by	ADP
fnp-3049	70	13	a	a	DET
fnp-3049	70	14	second	second	ADJ
fnp-3049	70	15	step	step	NOUN
fnp-3049	70	16	of	of	ADP
fnp-3049	70	17	centrifugation	centrifugation	NOUN
fnp-3049	70	18	at	at	ADP
fnp-3049	70	19	15,800	15,800	NUM
fnp-3049	70	20	g.	g.	NOUN
fnp-3049	70	21	the	the	DET
fnp-3049	70	22	resulting	result	VERB
fnp-3049	70	23	pellet	pellet	NOUN
fnp-3049	70	24	was	be	AUX
fnp-3049	70	25	resuspended	resuspend	VERB
fnp-3049	70	26	in	in	ADP
fnp-3049	70	27	acetone	acetone	NOUN
fnp-3049	70	28	to	to	PART
fnp-3049	70	29	dry	dry	VERB
fnp-3049	70	30	and	and	CCONJ
fnp-3049	70	31	collected	collect	VERB
fnp-3049	70	32	in	in	ADP
fnp-3049	70	33	control	control	NOUN
fnp-3049	70	34	plasma	plasma	NOUN
fnp-3049	70	35	to	to	PART
fnp-3049	70	36	store	store	VERB
fnp-3049	70	37	at	at	ADP
fnp-3049	70	38	-20	-20	NUM
fnp-3049	70	39	°	°	NOUN
fnp-3049	70	40	c	c	NOUN
fnp-3049	70	41	for	for	ADP
fnp-3049	70	42	future	future	ADJ
fnp-3049	70	43	analysis	analysis	NOUN
fnp-3049	70	44	.	.	PUNCT
fnp-3049	71	1	frozen	frozen	ADJ
fnp-3049	71	2	heparinized	heparinize	VERB
fnp-3049	71	3	plasma	plasma	NOUN
fnp-3049	71	4	samples	sample	NOUN
fnp-3049	71	5	were	be	AUX
fnp-3049	71	6	blind	blind	ADJ
fnp-3049	71	7	-	-	PUNCT
fnp-3049	71	8	coded	code	VERB
fnp-3049	71	9	and	and	CCONJ
fnp-3049	71	10	analyzed	analyze	VERB
fnp-3049	71	11	by	by	ADP
fnp-3049	71	12	charles	charles	PROPN
fnp-3049	71	13	river	river	PROPN
fnp-3049	71	14	laboratories	laboratory	NOUN
fnp-3049	71	15	(	(	PUNCT
fnp-3049	71	16	mattawan	mattawan	NOUN
fnp-3049	71	17	,	,	PUNCT
fnp-3049	71	18	mi	mi	PROPN
fnp-3049	71	19	)	)	PUNCT
fnp-3049	71	20	for	for	ADP
fnp-3049	71	21	the	the	DET
fnp-3049	71	22	concentrations	concentration	NOUN
fnp-3049	71	23	of	of	ADP
fnp-3049	71	24	the	the	DET
fnp-3049	71	25	msdc-0160	msdc-0160	ADJ
fnp-3049	71	26	metabolite	metabolite	NOUN
fnp-3049	71	27	msdc-0037	msdc-0037	NOUN
fnp-3049	71	28	in	in	ADP
fnp-3049	71	29	study	study	NOUN
fnp-3049	71	30	protocol	protocol	NOUN
fnp-3049	71	31	1443	1443	NUM
fnp-3049	71	32	-	-	PUNCT
fnp-3049	71	33	007b	007b	NOUN
fnp-3049	71	34	.	.	PUNCT
fnp-3049	72	1	in	in	ADP
fnp-3049	72	2	short	short	ADJ
fnp-3049	72	3	,	,	PUNCT
fnp-3049	72	4	each	each	DET
fnp-3049	72	5	25	25	NUM
fnp-3049	72	6	μl	μl	ADP
fnp-3049	72	7	aliquot	aliquot	NOUN
fnp-3049	72	8	of	of	ADP
fnp-3049	72	9	standard	standard	PROPN
fnp-3049	72	10	,	,	PUNCT
fnp-3049	72	11	qc	qc	PROPN
fnp-3049	72	12	sample	sample	NOUN
fnp-3049	72	13	,	,	PUNCT
fnp-3049	72	14	or	or	CCONJ
fnp-3049	72	15	study	study	NOUN
fnp-3049	72	16	sample	sample	NOUN
fnp-3049	72	17	was	be	AUX
fnp-3049	72	18	mixed	mix	VERB
fnp-3049	72	19	with	with	ADP
fnp-3049	72	20	10	10	NUM
fnp-3049	72	21	μl	μl	ADP
fnp-3049	72	22	of	of	ADP
fnp-3049	72	23	working	work	VERB
fnp-3049	72	24	internal	internal	ADJ
fnp-3049	72	25	standard	standard	ADJ
fnp-3049	72	26	solution	solution	NOUN
fnp-3049	72	27	(	(	PUNCT
fnp-3049	72	28	1,250	1,250	NUM
fnp-3049	72	29	ng	ng	NOUN
fnp-3049	72	30	/	/	SYM
fnp-3049	72	31	ml	ml	NOUN
fnp-3049	72	32	in	in	ADP
fnp-3049	72	33	methanol	methanol	NOUN
fnp-3049	72	34	/	/	SYM
fnp-3049	72	35	water	water	NOUN
fnp-3049	73	1	[	[	X
fnp-3049	73	2	50/50	50/50	NUM
fnp-3049	73	3	,	,	PUNCT
fnp-3049	73	4	v	v	NOUN
fnp-3049	73	5	/	/	SYM
fnp-3049	73	6	v	v	NOUN
fnp-3049	73	7	]	]	PUNCT
fnp-3049	73	8	)	)	PUNCT
fnp-3049	73	9	and	and	CCONJ
fnp-3049	73	10	140	140	NUM
fnp-3049	73	11	μl	μl	ADP
fnp-3049	73	12	of	of	ADP
fnp-3049	73	13	water	water	NOUN
fnp-3049	73	14	.	.	PUNCT
fnp-3049	74	1	the	the	DET
fnp-3049	74	2	samples	sample	NOUN
fnp-3049	74	3	were	be	AUX
fnp-3049	74	4	vortexed	vortexe	VERB
fnp-3049	74	5	and	and	CCONJ
fnp-3049	74	6	transferred	transfer	VERB
fnp-3049	74	7	to	to	ADP
fnp-3049	74	8	an	an	DET
fnp-3049	74	9	isolute	isolute	ADJ
fnp-3049	74	10	sle	sle	PROPN
fnp-3049	74	11	plate	plate	NOUN
fnp-3049	74	12	and	and	CCONJ
fnp-3049	74	13	eluted	elute	VERB
fnp-3049	74	14	with	with	ADP
fnp-3049	74	15	1.0	1.0	NUM
fnp-3049	74	16	ml	ml	NOUN
fnp-3049	74	17	of	of	ADP
fnp-3049	74	18	mtbe	mtbe	NOUN
fnp-3049	74	19	.	.	PUNCT
fnp-3049	75	1	the	the	DET
fnp-3049	75	2	samples	sample	NOUN
fnp-3049	75	3	were	be	AUX
fnp-3049	75	4	evaporated	evaporate	VERB
fnp-3049	75	5	and	and	CCONJ
fnp-3049	75	6	reconstituted	reconstitute	VERB
fnp-3049	75	7	with	with	ADP
fnp-3049	75	8	100	100	NUM
fnp-3049	75	9	μl	μl	ADP
fnp-3049	75	10	of	of	ADP
fnp-3049	75	11	methanol	methanol	NOUN
fnp-3049	75	12	followed	follow	VERB
fnp-3049	75	13	by	by	ADP
fnp-3049	75	14	100	100	NUM
fnp-3049	75	15	μl	μl	ADP
fnp-3049	75	16	of	of	ADP
fnp-3049	75	17	5	5	NUM
fnp-3049	75	18	mm	mm	NOUN
fnp-3049	75	19	ammonium	ammonium	NOUN
fnp-3049	75	20	formate	formate	NOUN
fnp-3049	75	21	in	in	ADP
fnp-3049	75	22	water	water	NOUN
fnp-3049	75	23	.	.	PUNCT
fnp-3049	76	1	the	the	DET
fnp-3049	76	2	samples	sample	NOUN
fnp-3049	76	3	were	be	AUX
fnp-3049	76	4	mixed	mix	VERB
fnp-3049	76	5	and	and	CCONJ
fnp-3049	76	6	transferred	transfer	VERB
fnp-3049	76	7	to	to	ADP
fnp-3049	76	8	a	a	DET
fnp-3049	76	9	clean	clean	ADJ
fnp-3049	76	10	96	96	NUM
fnp-3049	76	11	-	-	PUNCT
fnp-3049	76	12	well	well	NOUN
fnp-3049	76	13	plate	plate	NOUN
fnp-3049	76	14	.	.	PUNCT
fnp-3049	77	1	an	an	DET
fnp-3049	77	2	aliquot	aliquot	NOUN
fnp-3049	77	3	was	be	AUX
fnp-3049	77	4	injected	inject	VERB
fnp-3049	77	5	onto	onto	ADP
fnp-3049	77	6	an	an	DET
fnp-3049	77	7	lc	lc	NOUN
fnp-3049	77	8	ms	ms	PROPN
fnp-3049	77	9	/	/	SYM
fnp-3049	77	10	ms	ms	PROPN
fnp-3049	77	11	system	system	NOUN
fnp-3049	77	12	for	for	ADP
fnp-3049	77	13	analysis	analysis	NOUN
fnp-3049	77	14	.	.	PUNCT
fnp-3049	78	1	the	the	DET
fnp-3049	78	2	liquid	liquid	ADJ
fnp-3049	78	3	chromatography	chromatography	NOUN
fnp-3049	78	4	system	system	NOUN
fnp-3049	78	5	used	use	VERB
fnp-3049	78	6	a	a	DET
fnp-3049	78	7	macmod	macmod	NOUN
fnp-3049	78	8	ace	ace	NOUN
fnp-3049	78	9	3	3	NUM
fnp-3049	78	10	c18	c18	NOUN
fnp-3049	78	11	column	column	NOUN
fnp-3049	78	12	,	,	PUNCT
fnp-3049	78	13	2.1	2.1	NUM
fnp-3049	78	14	x	x	SYM
fnp-3049	78	15	50	50	NUM
fnp-3049	78	16	mm	mm	NOUN
fnp-3049	78	17	(	(	PUNCT
fnp-3049	78	18	3	3	NUM
fnp-3049	78	19	μm	μm	NOUN
fnp-3049	78	20	particle	particle	NOUN
fnp-3049	78	21	size	size	NOUN
fnp-3049	78	22	)	)	PUNCT
fnp-3049	78	23	with	with	ADP
fnp-3049	78	24	a	a	DET
fnp-3049	78	25	gradient	gradient	ADJ
fnp-3049	78	26	flow	flow	NOUN
fnp-3049	78	27	consisting	consist	VERB
fnp-3049	78	28	of	of	ADP
fnp-3049	78	29	5	5	NUM
fnp-3049	78	30	mm	mm	NOUN
fnp-3049	78	31	ammonium	ammonium	NOUN
fnp-3049	78	32	formate	formate	NOUN
fnp-3049	78	33	in	in	ADP
fnp-3049	78	34	water	water	NOUN
fnp-3049	78	35	/	/	SYM
fnp-3049	78	36	methanol	methanol	NOUN
fnp-3049	78	37	(	(	PUNCT
fnp-3049	78	38	75/25	75/25	NUM
fnp-3049	78	39	,	,	PUNCT
fnp-3049	78	40	v	v	NOUN
fnp-3049	78	41	/	/	SYM
fnp-3049	78	42	v	v	NOUN
fnp-3049	78	43	)	)	PUNCT
fnp-3049	78	44	and	and	CCONJ
fnp-3049	78	45	5	5	NUM
fnp-3049	78	46	mm	mm	NOUN
fnp-3049	78	47	ammonium	ammonium	NOUN
fnp-3049	78	48	formate	formate	NOUN
fnp-3049	78	49	in	in	ADP
fnp-3049	78	50	methanol	methanol	NOUN
fnp-3049	78	51	/	/	SYM
fnp-3049	78	52	acetonitrile	acetonitrile	ADJ
fnp-3049	78	53	/	/	SYM
fnp-3049	78	54	water	water	NOUN
fnp-3049	78	55	(	(	PUNCT
fnp-3049	78	56	72/18/10	72/18/10	PROPN
fnp-3049	78	57	,	,	PUNCT
fnp-3049	78	58	v	v	NOUN
fnp-3049	78	59	/	/	SYM
fnp-3049	78	60	v	v	NOUN
fnp-3049	78	61	/	/	SYM
fnp-3049	78	62	v	v	NOUN
fnp-3049	78	63	)	)	PUNCT
fnp-3049	78	64	at	at	ADP
fnp-3049	78	65	a	a	DET
fnp-3049	78	66	flow	flow	NOUN
fnp-3049	78	67	rate	rate	NOUN
fnp-3049	78	68	of	of	ADP
fnp-3049	78	69	500	500	NUM
fnp-3049	78	70	μl	μl	ADJ
fnp-3049	78	71	/	/	SYM
fnp-3049	78	72	minute	minute	NOUN
fnp-3049	78	73	.	.	PUNCT
fnp-3049	79	1	the	the	DET
fnp-3049	79	2	analyte	analyte	NOUN
fnp-3049	79	3	,	,	PUNCT
fnp-3049	79	4	metabolite	metabolite	NOUN
fnp-3049	79	5	,	,	PUNCT
fnp-3049	79	6	and	and	CCONJ
fnp-3049	79	7	internal	internal	ADJ
fnp-3049	79	8	standard	standard	NOUN
fnp-3049	79	9	were	be	AUX
fnp-3049	79	10	detected	detect	VERB
fnp-3049	79	11	using	use	VERB
fnp-3049	79	12	a	a	DET
fnp-3049	79	13	sciex	sciex	NOUN
fnp-3049	79	14	api	api	NOUN
fnp-3049	79	15	5000	5000	NUM
fnp-3049	79	16	triple	triple	ADJ
fnp-3049	79	17	quadrupole	quadrupole	NOUN
fnp-3049	79	18	lc	lc	PROPN
fnp-3049	79	19	ms	ms	PROPN
fnp-3049	79	20	/	/	SYM
fnp-3049	79	21	ms	ms	PROPN
fnp-3049	79	22	system	system	NOUN
fnp-3049	79	23	equipped	equip	VERB
fnp-3049	79	24	with	with	ADP
fnp-3049	79	25	an	an	DET
fnp-3049	79	26	esi	esi	PROPN
fnp-3049	79	27	(	(	PUNCT
fnp-3049	79	28	turboionspray	turboionspray	PROPN
fnp-3049	79	29	®	®	NOUN
fnp-3049	79	30	)	)	PUNCT
fnp-3049	79	31	ionization	ionization	NOUN
fnp-3049	79	32	source	source	NOUN
fnp-3049	79	33	operated	operate	VERB
fnp-3049	79	34	in	in	ADP
fnp-3049	79	35	the	the	DET
fnp-3049	79	36	positive	positive	ADJ
fnp-3049	79	37	ion	ion	NOUN
fnp-3049	79	38	mode	mode	NOUN
fnp-3049	79	39	.	.	PUNCT
fnp-3049	80	1	the	the	DET
fnp-3049	80	2	multiple	multiple	ADJ
fnp-3049	80	3	reaction	reaction	NOUN
fnp-3049	80	4	monitoring	monitor	VERB
fnp-3049	80	5	transitions	transition	NOUN
fnp-3049	80	6	of	of	ADP
fnp-3049	80	7	the	the	DET
fnp-3049	80	8	respective	respective	ADJ
fnp-3049	80	9	[	[	X
fnp-3049	80	10	m+h]+	m+h]+	NOUN
fnp-3049	80	11	ions	ion	NOUN
fnp-3049	80	12	were	be	AUX
fnp-3049	80	13	used	use	VERB
fnp-3049	80	14	to	to	PART
fnp-3049	80	15	monitor	monitor	VERB
fnp-3049	80	16	msdc-0160	msdc-0160	ADJ
fnp-3049	80	17	and	and	CCONJ
fnp-3049	80	18	msdc-0037	msdc-0037	ADJ
fnp-3049	80	19	as	as	SCONJ
fnp-3049	80	20	have	have	AUX
fnp-3049	80	21	previously	previously	ADV
fnp-3049	80	22	been	be	AUX
fnp-3049	80	23	described	describe	VERB
fnp-3049	80	24	for	for	ADP
fnp-3049	80	25	clinical	clinical	ADJ
fnp-3049	80	26	studies15	studies15	NOUN
fnp-3049	80	27	.	.	PUNCT
fnp-3049	81	1	western	western	ADJ
fnp-3049	81	2	blotting	blotting	ADJ
fnp-3049	81	3	rats	rat	NOUN
fnp-3049	81	4	were	be	AUX
fnp-3049	81	5	euthanized	euthanize	VERB
fnp-3049	81	6	with	with	ADP
fnp-3049	81	7	sodium	sodium	NOUN
fnp-3049	81	8	pentobarbital	pentobarbital	NOUN
fnp-3049	81	9	(	(	PUNCT
fnp-3049	81	10	130	130	NUM
fnp-3049	81	11	mg	mg	NUM
fnp-3049	81	12	/	/	SYM
fnp-3049	81	13	kg	kg	PROPN
fnp-3049	81	14	;	;	PUNCT
fnp-3049	81	15	sigma	sigma	PROPN
fnp-3049	81	16	)	)	PUNCT
fnp-3049	81	17	and	and	CCONJ
fnp-3049	81	18	transcardially	transcardially	ADV
fnp-3049	81	19	perfused	perfuse	VERB
fnp-3049	81	20	with	with	ADP
fnp-3049	81	21	pbs	pbs	PROPN
fnp-3049	81	22	to	to	PART
fnp-3049	81	23	remove	remove	VERB
fnp-3049	81	24	blood	blood	NOUN
fnp-3049	81	25	.	.	PUNCT
fnp-3049	82	1	brains	brain	NOUN
fnp-3049	82	2	were	be	AUX
fnp-3049	82	3	isolated	isolate	VERB
fnp-3049	82	4	and	and	CCONJ
fnp-3049	82	5	the	the	DET
fnp-3049	82	6	substantia	substantia	NOUN
fnp-3049	82	7	nigra	nigra	NOUN
fnp-3049	82	8	was	be	AUX
fnp-3049	82	9	dissected	dissect	VERB
fnp-3049	82	10	on	on	ADP
fnp-3049	82	11	ice	ice	NOUN
fnp-3049	82	12	using	use	VERB
fnp-3049	82	13	a	a	DET
fnp-3049	82	14	rat	rat	NOUN
fnp-3049	82	15	brain	brain	NOUN
fnp-3049	82	16	matrix	matrix	NOUN
fnp-3049	82	17	.	.	PUNCT
fnp-3049	83	1	isolated	isolate	VERB
fnp-3049	83	2	samples	sample	NOUN
fnp-3049	83	3	were	be	AUX
fnp-3049	83	4	snap	snap	ADJ
fnp-3049	83	5	frozen	frozen	ADJ
fnp-3049	83	6	and	and	CCONJ
fnp-3049	83	7	stored	store	VERB
fnp-3049	83	8	at	at	ADP
fnp-3049	83	9	-80	-80	NOUN
fnp-3049	83	10	°	°	NOUN
fnp-3049	83	11	c	c	NOUN
fnp-3049	83	12	for	for	ADP
fnp-3049	83	13	later	later	ADJ
fnp-3049	83	14	analysis	analysis	NOUN
fnp-3049	83	15	.	.	PUNCT
fnp-3049	84	1	frozen	frozen	ADJ
fnp-3049	84	2	tissue	tissue	NOUN
fnp-3049	84	3	was	be	AUX
fnp-3049	84	4	weighed	weigh	VERB
fnp-3049	84	5	in	in	ADP
fnp-3049	84	6	equilibrated	equilibrate	VERB
fnp-3049	84	7	eppendorf	eppendorf	PROPN
fnp-3049	84	8	tubes	tube	NOUN
fnp-3049	84	9	and	and	CCONJ
fnp-3049	84	10	homogenized	homogenize	VERB
fnp-3049	84	11	in	in	ADP
fnp-3049	84	12	pbs	pbs	PROPN
fnp-3049	84	13	10	10	NUM
fnp-3049	84	14	%	%	NOUN
fnp-3049	84	15	w	w	NOUN
fnp-3049	84	16	/	/	SYM
fnp-3049	84	17	v	v	NOUN
fnp-3049	84	18	with	with	ADP
fnp-3049	84	19	protease	protease	NOUN
fnp-3049	84	20	and	and	CCONJ
fnp-3049	84	21	phosphatase	phosphatase	NOUN
fnp-3049	84	22	inhibitors	inhibitor	NOUN
fnp-3049	84	23	(	(	PUNCT
fnp-3049	84	24	thermofisher	thermofisher	ADJ
fnp-3049	84	25	)	)	PUNCT
fnp-3049	84	26	.	.	PUNCT
fnp-3049	85	1	homogenization	homogenization	NOUN
fnp-3049	85	2	was	be	AUX
fnp-3049	85	3	performed	perform	VERB
fnp-3049	85	4	by	by	ADP
fnp-3049	85	5	probe	probe	NOUN
fnp-3049	85	6	sonication	sonication	NOUN
fnp-3049	85	7	at	at	ADP
fnp-3049	85	8	4	4	NUM
fnp-3049	85	9	°	°	ADP
fnp-3049	85	10	c	c	NOUN
fnp-3049	85	11	for	for	ADP
fnp-3049	85	12	2	2	NUM
fnp-3049	85	13	rounds	round	NOUN
fnp-3049	85	14	of	of	ADP
fnp-3049	85	15	15	15	NUM
fnp-3049	85	16	s	s	NOUN
fnp-3049	85	17	pulses	pulse	NOUN
fnp-3049	85	18	at	at	ADP
fnp-3049	85	19	0.5	0.5	NUM
fnp-3049	85	20	hz	hz	VERB
fnp-3049	85	21	with	with	ADP
fnp-3049	85	22	a	a	DET
fnp-3049	85	23	10	10	NUM
fnp-3049	85	24	%	%	NOUN
fnp-3049	85	25	amplitude	amplitude	NOUN
fnp-3049	85	26	.	.	PUNCT
fnp-3049	86	1	the	the	DET
fnp-3049	86	2	whole	whole	ADJ
fnp-3049	86	3	homogenates	homogenate	NOUN
fnp-3049	86	4	were	be	AUX
fnp-3049	86	5	centrifuged	centrifuge	VERB
fnp-3049	86	6	for	for	ADP
fnp-3049	86	7	10	10	NUM
fnp-3049	86	8	min	min	NOUN
fnp-3049	86	9	at	at	ADP
fnp-3049	86	10	6000	6000	NUM
fnp-3049	86	11	x	x	SYM
fnp-3049	86	12	g	g	NOUN
fnp-3049	86	13	at	at	ADP
fnp-3049	86	14	4	4	NUM
fnp-3049	86	15	°	°	NOUN
fnp-3049	86	16	c	c	NOUN
fnp-3049	86	17	.	.	PUNCT
fnp-3049	87	1	the	the	DET
fnp-3049	87	2	pellet	pellet	NOUN
fnp-3049	87	3	was	be	AUX
fnp-3049	87	4	discarded	discard	VERB
fnp-3049	87	5	and	and	CCONJ
fnp-3049	87	6	supernatant	supernatant	NOUN
fnp-3049	87	7	was	be	AUX
fnp-3049	87	8	collected	collect	VERB
fnp-3049	87	9	for	for	ADP
fnp-3049	87	10	analysis	analysis	NOUN
fnp-3049	87	11	.	.	PUNCT
fnp-3049	88	1	to	to	PART
fnp-3049	88	2	isolate	isolate	VERB
fnp-3049	88	3	insoluble	insoluble	ADJ
fnp-3049	88	4	αsyn	αsyn	NOUN
fnp-3049	88	5	,	,	PUNCT
fnp-3049	88	6	20	20	NUM
fnp-3049	88	7	%	%	NOUN
fnp-3049	88	8	sarkosyl	sarkosyl	NOUN
fnp-3049	88	9	was	be	AUX
fnp-3049	88	10	added	add	VERB
fnp-3049	88	11	to	to	ADP
fnp-3049	88	12	the	the	DET
fnp-3049	88	13	whole	whole	ADJ
fnp-3049	88	14	homogenate	homogenate	NOUN
fnp-3049	88	15	to	to	PART
fnp-3049	88	16	result	result	VERB
fnp-3049	88	17	in	in	ADP
fnp-3049	88	18	a	a	DET
fnp-3049	88	19	1	1	NUM
fnp-3049	88	20	%	%	NOUN
fnp-3049	88	21	sarkosyl	sarkosyl	NOUN
fnp-3049	88	22	pbs	pbs	PROPN
fnp-3049	88	23	sample	sample	NOUN
fnp-3049	88	24	that	that	PRON
fnp-3049	88	25	was	be	AUX
fnp-3049	88	26	incubated	incubate	VERB
fnp-3049	88	27	on	on	ADP
fnp-3049	88	28	a	a	DET
fnp-3049	88	29	rotating	rotate	VERB
fnp-3049	88	30	shaker	shaker	NOUN
fnp-3049	88	31	for	for	ADP
fnp-3049	88	32	1	1	NUM
fnp-3049	88	33	h	h	NOUN
fnp-3049	88	34	at	at	ADP
fnp-3049	88	35	room	room	NOUN
fnp-3049	88	36	temperature	temperature	NOUN
fnp-3049	88	37	.	.	PUNCT
fnp-3049	89	1	after	after	ADP
fnp-3049	89	2	incubation	incubation	NOUN
fnp-3049	89	3	,	,	PUNCT
fnp-3049	89	4	samples	sample	NOUN
fnp-3049	89	5	were	be	AUX
fnp-3049	89	6	centrifuged	centrifuge	VERB
fnp-3049	89	7	for	for	ADP
fnp-3049	89	8	10	10	NUM
fnp-3049	89	9	min	min	NOUN
fnp-3049	89	10	at	at	ADP
fnp-3049	89	11	6000	6000	NUM
fnp-3049	89	12	x	x	SYM
fnp-3049	89	13	g	g	NOUN
fnp-3049	89	14	at	at	ADP
fnp-3049	89	15	4	4	NUM
fnp-3049	89	16	°	°	ADP
fnp-3049	89	17	c	c	NOUN
fnp-3049	89	18	to	to	PART
fnp-3049	89	19	remove	remove	VERB
fnp-3049	89	20	remaining	remain	VERB
fnp-3049	89	21	cell	cell	NOUN
fnp-3049	89	22	debris	debris	NOUN
fnp-3049	89	23	.	.	PUNCT
fnp-3049	90	1	the	the	DET
fnp-3049	90	2	cleared	clear	VERB
fnp-3049	90	3	supernatant	supernatant	NOUN
fnp-3049	90	4	was	be	AUX
fnp-3049	90	5	centrifuged	centrifuge	VERB
fnp-3049	90	6	at	at	ADP
fnp-3049	90	7	100,000	100,000	NUM
fnp-3049	90	8	x	x	SYM
fnp-3049	90	9	g	g	NOUN
fnp-3049	90	10	for	for	ADP
fnp-3049	90	11	60	60	NUM
fnp-3049	90	12	min	min	NOUN
fnp-3049	90	13	and	and	CCONJ
fnp-3049	90	14	the	the	DET
fnp-3049	90	15	resulting	result	VERB
fnp-3049	90	16	pellet	pellet	NOUN
fnp-3049	90	17	was	be	AUX
fnp-3049	90	18	gently	gently	ADV
fnp-3049	90	19	washed	wash	VERB
fnp-3049	90	20	in	in	ADP
fnp-3049	90	21	pbs	pbs	PROPN
fnp-3049	90	22	after	after	ADP
fnp-3049	90	23	which	which	PRON
fnp-3049	90	24	it	it	PRON
fnp-3049	90	25	was	be	AUX
fnp-3049	90	26	resuspended	resuspend	VERB
fnp-3049	90	27	in	in	ADP
fnp-3049	90	28	1	1	NUM
fnp-3049	90	29	%	%	NOUN
fnp-3049	90	30	sarkosyl	sarkosyl	NOUN
fnp-3049	90	31	in	in	ADP
fnp-3049	90	32	pbs	pbs	PROPN
fnp-3049	90	33	with	with	ADP
fnp-3049	90	34	protease	protease	NOUN
fnp-3049	90	35	and	and	CCONJ
fnp-3049	90	36	phosphatase	phosphatase	ADJ
fnp-3049	90	37	inhibitors	inhibitor	NOUN
fnp-3049	90	38	.	.	PUNCT
fnp-3049	91	1	a	a	DET
fnp-3049	91	2	second	second	ADJ
fnp-3049	91	3	centrifugation	centrifugation	NOUN
fnp-3049	91	4	step	step	NOUN
fnp-3049	91	5	at	at	ADP
fnp-3049	91	6	100,000	100,000	NUM
fnp-3049	91	7	x	x	SYM
fnp-3049	91	8	g	g	NOUN
fnp-3049	91	9	for	for	ADP
fnp-3049	91	10	10	10	NUM
fnp-3049	91	11	min	min	NOUN
fnp-3049	91	12	was	be	AUX
fnp-3049	91	13	performed	perform	VERB
fnp-3049	91	14	to	to	PART
fnp-3049	91	15	collect	collect	VERB
fnp-3049	91	16	the	the	DET
fnp-3049	91	17	1	1	NUM
fnp-3049	91	18	%	%	NOUN
fnp-3049	91	19	sarkosyl	sarkosyl	NOUN
fnp-3049	91	20	insoluble	insoluble	ADJ
fnp-3049	91	21	pellet	pellet	NOUN
fnp-3049	91	22	.	.	PUNCT
fnp-3049	92	1	protein	protein	NOUN
fnp-3049	92	2	concentrations	concentration	NOUN
fnp-3049	92	3	were	be	AUX
fnp-3049	92	4	estimated	estimate	VERB
fnp-3049	92	5	using	use	VERB
fnp-3049	92	6	a	a	DET
fnp-3049	92	7	bca	bca	PROPN
fnp-3049	92	8	kit	kit	NOUN
fnp-3049	92	9	(	(	PUNCT
fnp-3049	92	10	thermo	thermo	NOUN
fnp-3049	92	11	fisher	fisher	PROPN
fnp-3049	92	12	)	)	PUNCT
fnp-3049	92	13	.	.	PUNCT
fnp-3049	93	1	samples	sample	NOUN
fnp-3049	93	2	were	be	AUX
fnp-3049	93	3	prepared	prepare	VERB
fnp-3049	93	4	with	with	ADP
fnp-3049	93	5	laemmli	laemmli	NOUN
fnp-3049	93	6	buffer	buffer	NOUN
fnp-3049	93	7	containing	contain	VERB
fnp-3049	93	8	2	2	NUM
fnp-3049	93	9	%	%	NOUN
fnp-3049	93	10	sds	sds	NOUN
fnp-3049	93	11	,	,	PUNCT
fnp-3049	93	12	heated	heat	VERB
fnp-3049	93	13	at	at	ADP
fnp-3049	93	14	95	95	NUM
fnp-3049	93	15	°	°	ADP
fnp-3049	93	16	c	c	NOUN
fnp-3049	93	17	for	for	ADP
fnp-3049	93	18	10	10	NUM
fnp-3049	93	19	min	min	NOUN
fnp-3049	93	20	for	for	ADP
fnp-3049	93	21	denaturation	denaturation	NOUN
fnp-3049	93	22	and	and	CCONJ
fnp-3049	93	23	stored	store	VERB
fnp-3049	93	24	at	at	ADP
fnp-3049	93	25	-80	-80	NOUN
fnp-3049	93	26	°	°	NOUN
fnp-3049	93	27	c	c	NOUN
fnp-3049	93	28	.	.	PUNCT
fnp-3049	94	1	protein	protein	NOUN
fnp-3049	94	2	samples	sample	NOUN
fnp-3049	94	3	were	be	AUX
fnp-3049	94	4	separated	separate	VERB
fnp-3049	94	5	via	via	ADP
fnp-3049	94	6	4	4	NUM
fnp-3049	94	7	-	-	SYM
fnp-3049	94	8	15	15	NUM
fnp-3049	94	9	%	%	NOUN
fnp-3049	94	10	sds	sds	NOUN
fnp-3049	94	11	page	page	NOUN
fnp-3049	94	12	(	(	PUNCT
fnp-3049	94	13	biorad	biorad	NOUN
fnp-3049	94	14	)	)	PUNCT
fnp-3049	94	15	and	and	CCONJ
fnp-3049	94	16	transferred	transfer	VERB
fnp-3049	94	17	to	to	ADP
fnp-3049	94	18	a	a	DET
fnp-3049	94	19	pvdf	pvdf	ADJ
fnp-3049	94	20	membrane	membrane	NOUN
fnp-3049	94	21	using	use	VERB
fnp-3049	94	22	the	the	DET
fnp-3049	94	23	biorad	biorad	ADJ
fnp-3049	94	24	turboblot	turboblot	NOUN
fnp-3049	94	25	system	system	NOUN
fnp-3049	94	26	.	.	PUNCT
fnp-3049	95	1	pvdf	pvdf	PROPN
fnp-3049	95	2	membranes	membrane	NOUN
fnp-3049	95	3	were	be	AUX
fnp-3049	95	4	blocked	block	VERB
fnp-3049	95	5	with	with	ADP
fnp-3049	95	6	5	5	NUM
fnp-3049	95	7	%	%	NOUN
fnp-3049	95	8	bsa	bsa	PROPN
fnp-3049	95	9	in	in	ADP
fnp-3049	95	10	pbs	pbs	PROPN
fnp-3049	95	11	during	during	ADP
fnp-3049	95	12	30	30	NUM
fnp-3049	95	13	min	min	NOUN
fnp-3049	95	14	at	at	ADP
fnp-3049	95	15	room	room	NOUN
fnp-3049	95	16	temperature	temperature	NOUN
fnp-3049	95	17	.	.	PUNCT
fnp-3049	96	1	overnight	overnight	ADJ
fnp-3049	96	2	incubation	incubation	NOUN
fnp-3049	96	3	with	with	ADP
fnp-3049	96	4	primary	primary	ADJ
fnp-3049	96	5	antibody	antibody	NOUN
fnp-3049	96	6	,	,	PUNCT
fnp-3049	96	7	iba-1	iba-1	PUNCT
fnp-3049	96	8	(	(	PUNCT
fnp-3049	96	9	1:500	1:500	NUM
fnp-3049	96	10	,	,	PUNCT
fnp-3049	96	11	wako	wako	PROPN
fnp-3049	96	12	)	)	PUNCT
fnp-3049	96	13	,	,	PUNCT
fnp-3049	96	14	human	human	ADJ
fnp-3049	96	15	αsyn	αsyn	NOUN
fnp-3049	96	16	(	(	PUNCT
fnp-3049	96	17	4b12	4b12	NOUN
fnp-3049	96	18	,	,	PUNCT
fnp-3049	96	19	1:1000	1:1000	NUM
fnp-3049	96	20	,	,	PUNCT
fnp-3049	96	21	biolegend	biolegend	NOUN
fnp-3049	96	22	)	)	PUNCT
fnp-3049	96	23	,	,	PUNCT
fnp-3049	96	24	pser129	pser129	PROPN
fnp-3049	96	25	-	-	ADJ
fnp-3049	96	26	αsyn	αsyn	NOUN
fnp-3049	96	27	(	(	PUNCT
fnp-3049	96	28	ps129	ps129	PROPN
fnp-3049	96	29	,	,	PUNCT
fnp-3049	96	30	1:5000	1:5000	NUM
fnp-3049	96	31	,	,	PUNCT
fnp-3049	96	32	abcam	abcam	NOUN
fnp-3049	96	33	)	)	PUNCT
fnp-3049	96	34	,	,	PUNCT
fnp-3049	96	35	lamp1	lamp1	NOUN
fnp-3049	96	36	(	(	PUNCT
fnp-3049	96	37	1:1000	1:1000	NUM
fnp-3049	96	38	,	,	PUNCT
fnp-3049	96	39	abcam	abcam	PROPN
fnp-3049	96	40	)	)	PUNCT
fnp-3049	96	41	,	,	PUNCT
fnp-3049	96	42	caspase	caspase	NOUN
fnp-3049	96	43	(	(	PUNCT
fnp-3049	96	44	1:500	1:500	NUM
fnp-3049	96	45	,	,	PUNCT
fnp-3049	96	46	abcam	abcam	PROPN
fnp-3049	96	47	)	)	PUNCT
fnp-3049	96	48	was	be	AUX
fnp-3049	96	49	followed	follow	VERB
fnp-3049	96	50	by	by	ADP
fnp-3049	96	51	incubation	incubation	NOUN
fnp-3049	96	52	with	with	ADP
fnp-3049	96	53	hrp	hrp	PROPN
fnp-3049	96	54	-	-	PUNCT
fnp-3049	96	55	conjugated	conjugate	VERB
fnp-3049	96	56	secondary	secondary	ADJ
fnp-3049	96	57	antibody	antibody	NOUN
fnp-3049	96	58	(	(	PUNCT
fnp-3049	96	59	cell	cell	NOUN
fnp-3049	96	60	signaling	signal	VERB
fnp-3049	96	61	technology	technology	NOUN
fnp-3049	96	62	)	)	PUNCT
fnp-3049	96	63	.	.	PUNCT
fnp-3049	97	1	signal	signal	PROPN
fnp-3049	97	2	was	be	AUX
fnp-3049	97	3	detected	detect	VERB
fnp-3049	97	4	by	by	ADP
fnp-3049	97	5	chemiluminescence	chemiluminescence	NOUN
fnp-3049	97	6	(	(	PUNCT
fnp-3049	97	7	pico	pico	NOUN
fnp-3049	97	8	chemiluminescent	chemiluminescent	NOUN
fnp-3049	97	9	substrate	substrate	NOUN
fnp-3049	97	10	,	,	PUNCT
fnp-3049	97	11	thermo	thermo	NOUN
fnp-3049	97	12	fisher	fisher	PROPN
fnp-3049	97	13	)	)	PUNCT
fnp-3049	97	14	using	use	VERB
fnp-3049	97	15	a	a	DET
fnp-3049	97	16	biorad	biorad	ADJ
fnp-3049	97	17	imager	imager	NOUN
fnp-3049	97	18	.	.	PUNCT
fnp-3049	98	1	western	western	ADJ
fnp-3049	98	2	blot	blot	NOUN
fnp-3049	98	3	bands	band	NOUN
fnp-3049	98	4	were	be	AUX
fnp-3049	98	5	quantified	quantify	VERB
fnp-3049	98	6	using	use	VERB
fnp-3049	98	7	imagej	imagej	ADJ
fnp-3049	98	8	software	software	NOUN
fnp-3049	98	9	.	.	PUNCT
fnp-3049	99	1	behavioral	behavioral	ADJ
fnp-3049	99	2	analysis	analysis	NOUN
fnp-3049	99	3	to	to	PART
fnp-3049	99	4	monitor	monitor	VERB
fnp-3049	99	5	functional	functional	ADJ
fnp-3049	99	6	deficits	deficit	NOUN
fnp-3049	99	7	related	relate	VERB
fnp-3049	99	8	to	to	ADP
fnp-3049	99	9	nigral	nigral	ADJ
fnp-3049	99	10	dopamine	dopamine	NOUN
fnp-3049	99	11	neuron	neuron	NOUN
fnp-3049	99	12	dysfunction	dysfunction	NOUN
fnp-3049	99	13	and	and	CCONJ
fnp-3049	99	14	death	death	NOUN
fnp-3049	99	15	,	,	PUNCT
fnp-3049	99	16	rats	rat	NOUN
fnp-3049	99	17	were	be	AUX
fnp-3049	99	18	subjected	subject	VERB
fnp-3049	99	19	to	to	ADP
fnp-3049	99	20	a	a	DET
fnp-3049	99	21	cylinder	cylinder	NOUN
fnp-3049	99	22	test	test	NOUN
fnp-3049	99	23	to	to	PART
fnp-3049	99	24	evaluate	evaluate	VERB
fnp-3049	99	25	spontaneous	spontaneous	ADJ
fnp-3049	99	26	forelimb	forelimb	NOUN
fnp-3049	99	27	use	use	NOUN
fnp-3049	99	28	.	.	PUNCT
fnp-3049	100	1	rats	rat	NOUN
fnp-3049	100	2	were	be	AUX
fnp-3049	100	3	placed	place	VERB
fnp-3049	100	4	in	in	ADP
fnp-3049	100	5	a	a	DET
fnp-3049	100	6	clear	clear	ADJ
fnp-3049	100	7	glass	glass	NOUN
fnp-3049	100	8	cylinder	cylinder	NOUN
fnp-3049	100	9	and	and	CCONJ
fnp-3049	100	10	were	be	AUX
fnp-3049	100	11	filmed	film	VERB
fnp-3049	100	12	for	for	ADP
fnp-3049	100	13	a	a	DET
fnp-3049	100	14	total	total	NOUN
fnp-3049	100	15	of	of	ADP
fnp-3049	100	16	30	30	NUM
fnp-3049	100	17	contacts	contact	NOUN
fnp-3049	100	18	with	with	ADP
fnp-3049	100	19	the	the	DET
fnp-3049	100	20	cylinder	cylinder	NOUN
fnp-3049	100	21	.	.	PUNCT
fnp-3049	101	1	percentage	percentage	NOUN
fnp-3049	101	2	of	of	ADP
fnp-3049	101	3	forepaw	forepaw	ADJ
fnp-3049	101	4	use	use	NOUN
fnp-3049	101	5	was	be	AUX
fnp-3049	101	6	expressed	express	VERB
fnp-3049	101	7	as	as	ADP
fnp-3049	101	8	the	the	DET
fnp-3049	101	9	percentage	percentage	NOUN
fnp-3049	101	10	of	of	ADP
fnp-3049	101	11	right	right	ADJ
fnp-3049	101	12	forepaw	forepaw	ADJ
fnp-3049	101	13	touches	touch	NOUN
fnp-3049	101	14	over	over	ADP
fnp-3049	101	15	total	total	ADJ
fnp-3049	101	16	number	number	NOUN
fnp-3049	101	17	of	of	ADP
fnp-3049	101	18	touches	touch	NOUN
fnp-3049	101	19	.	.	PUNCT
fnp-3049	102	1	non	non	ADJ
fnp-3049	102	2	-	-	ADJ
fnp-3049	102	3	lesioned	lesione	VERB
fnp-3049	102	4	rats	rat	NOUN
fnp-3049	102	5	score	score	VERB
fnp-3049	102	6	around	around	ADP
fnp-3049	102	7	50	50	NUM
fnp-3049	102	8	%	%	NOUN
fnp-3049	102	9	.	.	PUNCT
fnp-3049	103	1	to	to	PART
fnp-3049	103	2	examine	examine	VERB
fnp-3049	103	3	olfactory	olfactory	ADJ
fnp-3049	103	4	function	function	NOUN
fnp-3049	103	5	in	in	ADP
fnp-3049	103	6	mice	mouse	NOUN
fnp-3049	103	7	,	,	PUNCT
fnp-3049	103	8	the	the	DET
fnp-3049	103	9	buried	bury	VERB
fnp-3049	103	10	pellet	pellet	NOUN
fnp-3049	103	11	test	test	NOUN
fnp-3049	103	12	was	be	AUX
fnp-3049	103	13	carried	carry	VERB
fnp-3049	103	14	out	out	ADP
fnp-3049	103	15	as	as	SCONJ
fnp-3049	103	16	recently	recently	ADV
fnp-3049	103	17	described	describe	VERB
fnp-3049	103	18	by	by	ADP
fnp-3049	103	19	our	our	PRON
fnp-3049	103	20	laboratory	laboratory	NOUN
fnp-3049	103	21	in	in	ADP
fnp-3049	103	22	johnson	johnson	PROPN
fnp-3049	103	23	et	et	PROPN
fnp-3049	103	24	al.16	al.16	PROPN
fnp-3049	103	25	in	in	ADP
fnp-3049	103	26	short	short	ADJ
fnp-3049	103	27	,	,	PUNCT
fnp-3049	103	28	the	the	DET
fnp-3049	103	29	mice	mouse	NOUN
fnp-3049	103	30	were	be	AUX
fnp-3049	103	31	fasted	fast	VERB
fnp-3049	103	32	overnight	overnight	ADV
fnp-3049	103	33	starting	start	VERB
fnp-3049	103	34	three	three	NUM
fnp-3049	103	35	days	day	NOUN
fnp-3049	103	36	prior	prior	ADV
fnp-3049	103	37	to	to	ADP
fnp-3049	103	38	testing	testing	NOUN
fnp-3049	103	39	.	.	PUNCT
fnp-3049	104	1	throughout	throughout	ADP
fnp-3049	104	2	the	the	DET
fnp-3049	104	3	experiment	experiment	NOUN
fnp-3049	104	4	,	,	PUNCT
fnp-3049	104	5	their	their	PRON
fnp-3049	104	6	body	body	NOUN
fnp-3049	104	7	weight	weight	NOUN
fnp-3049	104	8	was	be	AUX
fnp-3049	104	9	monitored	monitor	VERB
fnp-3049	104	10	and	and	CCONJ
fnp-3049	104	11	mice	mouse	NOUN
fnp-3049	104	12	who	who	PRON
fnp-3049	104	13	lost	lose	VERB
fnp-3049	104	14	more	more	ADJ
fnp-3049	104	15	than	than	ADP
fnp-3049	104	16	10	10	NUM
fnp-3049	104	17	%	%	NOUN
fnp-3049	104	18	of	of	ADP
fnp-3049	104	19	their	their	PRON
fnp-3049	104	20	original	original	ADJ
fnp-3049	104	21	body	body	NOUN
fnp-3049	104	22	weight	weight	NOUN
fnp-3049	104	23	were	be	AUX
fnp-3049	104	24	excluded	exclude	VERB
fnp-3049	104	25	from	from	ADP
fnp-3049	104	26	further	further	ADJ
fnp-3049	104	27	fasting	fasting	NOUN
fnp-3049	104	28	and	and	CCONJ
fnp-3049	104	29	from	from	ADP
fnp-3049	104	30	the	the	DET
fnp-3049	104	31	experiment	experiment	NOUN
fnp-3049	104	32	.	.	PUNCT
fnp-3049	105	1	at	at	ADP
fnp-3049	105	2	the	the	DET
fnp-3049	105	3	first	first	ADJ
fnp-3049	105	4	day	day	NOUN
fnp-3049	105	5	of	of	ADP
fnp-3049	105	6	testing	testing	NOUN
fnp-3049	105	7	,	,	PUNCT
fnp-3049	105	8	a	a	DET
fnp-3049	105	9	surface	surface	NOUN
fnp-3049	105	10	test	test	NOUN
fnp-3049	105	11	was	be	AUX
fnp-3049	105	12	performed	perform	VERB
fnp-3049	105	13	,	,	PUNCT
fnp-3049	105	14	where	where	SCONJ
fnp-3049	105	15	the	the	DET
fnp-3049	105	16	treat	treat	NOUN
fnp-3049	105	17	(	(	PUNCT
fnp-3049	105	18	bio	bio	NOUN
fnp-3049	105	19	-	-	PUNCT
fnp-3049	105	20	serv	serv	NOUN
fnp-3049	105	21	,	,	PUNCT
fnp-3049	105	22	fruit	fruit	NOUN
fnp-3049	105	23	crunchies	crunchie	NOUN
fnp-3049	105	24	)	)	PUNCT
fnp-3049	105	25	was	be	AUX
fnp-3049	105	26	placed	place	VERB
fnp-3049	105	27	on	on	ADP
fnp-3049	105	28	top	top	NOUN
fnp-3049	105	29	of	of	ADP
fnp-3049	105	30	the	the	DET
fnp-3049	105	31	clean	clean	ADJ
fnp-3049	105	32	bedding	bedding	NOUN
fnp-3049	105	33	.	.	PUNCT
fnp-3049	106	1	mice	mouse	NOUN
fnp-3049	106	2	who	who	PRON
fnp-3049	106	3	were	be	AUX
fnp-3049	106	4	not	not	PART
fnp-3049	106	5	motivated	motivated	ADJ
fnp-3049	106	6	to	to	PART
fnp-3049	106	7	eat	eat	VERB
fnp-3049	106	8	the	the	DET
fnp-3049	106	9	treat	treat	NOUN
fnp-3049	106	10	were	be	AUX
fnp-3049	106	11	excluded	exclude	VERB
fnp-3049	106	12	from	from	ADP
fnp-3049	106	13	further	further	ADJ
fnp-3049	106	14	testing	testing	NOUN
fnp-3049	106	15	(	(	PUNCT
fnp-3049	106	16	all	all	DET
fnp-3049	106	17	mice	mouse	NOUN
fnp-3049	106	18	in	in	ADP
fnp-3049	106	19	this	this	DET
fnp-3049	106	20	study	study	NOUN
fnp-3049	106	21	were	be	AUX
fnp-3049	106	22	motivated	motivate	VERB
fnp-3049	106	23	by	by	ADP
fnp-3049	106	24	the	the	DET
fnp-3049	106	25	treat	treat	NOUN
fnp-3049	106	26	and	and	CCONJ
fnp-3049	106	27	were	be	AUX
fnp-3049	106	28	thus	thus	ADV
fnp-3049	106	29	included	include	VERB
fnp-3049	106	30	)	)	PUNCT
fnp-3049	106	31	.	.	PUNCT
fnp-3049	107	1	for	for	ADP
fnp-3049	107	2	four	four	NUM
fnp-3049	107	3	consecutive	consecutive	ADJ
fnp-3049	107	4	days	day	NOUN
fnp-3049	107	5	,	,	PUNCT
fnp-3049	107	6	the	the	DET
fnp-3049	107	7	treat	treat	NOUN
fnp-3049	107	8	was	be	AUX
fnp-3049	107	9	buried	bury	VERB
fnp-3049	107	10	at	at	ADP
fnp-3049	107	11	different	different	ADJ
fnp-3049	107	12	locations	location	NOUN
fnp-3049	107	13	1	1	NUM
fnp-3049	107	14	cm	cm	NOUN
fnp-3049	107	15	under	under	ADP
fnp-3049	107	16	the	the	DET
fnp-3049	107	17	clean	clean	ADJ
fnp-3049	107	18	bedding	bedding	NOUN
fnp-3049	107	19	and	and	CCONJ
fnp-3049	107	20	latency	latency	NOUN
fnp-3049	107	21	for	for	ADP
fnp-3049	107	22	mice	mouse	NOUN
fnp-3049	107	23	to	to	PART
fnp-3049	107	24	uncover	uncover	VERB
fnp-3049	107	25	it	it	PRON
fnp-3049	107	26	was	be	AUX
fnp-3049	107	27	recorded	record	VERB
fnp-3049	107	28	.	.	PUNCT
fnp-3049	108	1	a	a	DET
fnp-3049	108	2	maximum	maximum	ADJ
fnp-3049	108	3	time	time	NOUN
fnp-3049	108	4	was	be	AUX
fnp-3049	108	5	set	set	VERB
fnp-3049	108	6	at	at	ADP
fnp-3049	108	7	300	300	NUM
fnp-3049	108	8	s	s	NOUN
fnp-3049	108	9	,	,	PUNCT
fnp-3049	108	10	and	and	CCONJ
fnp-3049	108	11	if	if	SCONJ
fnp-3049	108	12	a	a	DET
fnp-3049	108	13	mouse	mouse	NOUN
fnp-3049	108	14	did	do	AUX
fnp-3049	108	15	not	not	PART
fnp-3049	108	16	uncover	uncover	VERB
fnp-3049	108	17	the	the	DET
fnp-3049	108	18	treat	treat	NOUN
fnp-3049	108	19	within	within	ADP
fnp-3049	108	20	that	that	DET
fnp-3049	108	21	time	time	NOUN
fnp-3049	108	22	frame	frame	NOUN
fnp-3049	108	23	,	,	PUNCT
fnp-3049	108	24	300	300	NUM
fnp-3049	108	25	s	s	VERB
fnp-3049	108	26	was	be	AUX
fnp-3049	108	27	recorded	record	VERB
fnp-3049	108	28	as	as	ADP
fnp-3049	108	29	its	its	PRON
fnp-3049	108	30	latency	latency	NOUN
fnp-3049	108	31	.	.	PUNCT
fnp-3049	109	1	the	the	DET
fnp-3049	109	2	average	average	ADJ
fnp-3049	109	3	latency	latency	NOUN
fnp-3049	109	4	to	to	PART
fnp-3049	109	5	uncover	uncover	VERB
fnp-3049	109	6	the	the	DET
fnp-3049	109	7	treat	treat	NOUN
fnp-3049	109	8	per	per	ADP
fnp-3049	109	9	animal	animal	NOUN
fnp-3049	109	10	is	be	AUX
fnp-3049	109	11	presented	present	VERB
fnp-3049	109	12	here	here	ADV
fnp-3049	109	13	,	,	PUNCT
fnp-3049	109	14	with	with	ADP
fnp-3049	109	15	nine	nine	NUM
fnp-3049	109	16	to	to	PART
fnp-3049	109	17	ten	ten	NUM
fnp-3049	109	18	animals	animal	NOUN
fnp-3049	109	19	analyzed	analyze	VERB
fnp-3049	109	20	per	per	ADP
fnp-3049	109	21	group	group	NOUN
fnp-3049	109	22	.	.	PUNCT
fnp-3049	110	1	immunohistochemistry	immunohistochemistry	NOUN
fnp-3049	110	2	mice	mouse	NOUN
fnp-3049	110	3	and	and	CCONJ
fnp-3049	110	4	rats	rat	NOUN
fnp-3049	110	5	were	be	AUX
fnp-3049	110	6	euthanized	euthanize	VERB
fnp-3049	110	7	with	with	ADP
fnp-3049	110	8	sodium	sodium	NOUN
fnp-3049	110	9	pentobarbital	pentobarbital	NOUN
fnp-3049	110	10	(	(	PUNCT
fnp-3049	110	11	60	60	NUM
fnp-3049	110	12	mg	mg	NUM
fnp-3049	110	13	/	/	SYM
fnp-3049	110	14	ml	ml	PROPN
fnp-3049	110	15	;	;	PUNCT
fnp-3049	110	16	sigma	sigma	PROPN
fnp-3049	110	17	)	)	PUNCT
fnp-3049	110	18	and	and	CCONJ
fnp-3049	110	19	transcardially	transcardially	ADV
fnp-3049	110	20	perfused	perfuse	VERB
fnp-3049	110	21	with	with	ADP
fnp-3049	110	22	room	room	NOUN
fnp-3049	110	23	temperature	temperature	NOUN
fnp-3049	110	24	0.9	0.9	NUM
fnp-3049	110	25	%	%	NOUN
fnp-3049	110	26	saline	saline	NOUN
fnp-3049	110	27	followed	follow	VERB
fnp-3049	110	28	by	by	ADP
fnp-3049	110	29	ice	ice	NOUN
fnp-3049	110	30	-	-	PUNCT
fnp-3049	110	31	cold	cold	ADJ
fnp-3049	110	32	4	4	NUM
fnp-3049	110	33	%	%	NOUN
fnp-3049	110	34	paraformaldehyde	paraformaldehyde	NOUN
fnp-3049	110	35	(	(	PUNCT
fnp-3049	110	36	pfa	pfa	NOUN
fnp-3049	110	37	)	)	PUNCT
fnp-3049	110	38	in	in	ADP
fnp-3049	110	39	0.1	0.1	NUM
fnp-3049	110	40	m	m	NOUN
fnp-3049	110	41	phosphate	phosphate	ADJ
fnp-3049	110	42	buffer	buffer	NOUN
fnp-3049	110	43	.	.	PUNCT
fnp-3049	111	1	brains	brain	NOUN
fnp-3049	111	2	were	be	AUX
fnp-3049	111	3	removed	remove	VERB
fnp-3049	111	4	,	,	PUNCT
fnp-3049	111	5	post	post	ADJ
fnp-3049	111	6	-	-	ADJ
fnp-3049	111	7	fixed	fix	VERB
fnp-3049	111	8	overnight	overnight	ADV
fnp-3049	111	9	at	at	ADP
fnp-3049	111	10	4	4	NUM
fnp-3049	111	11	°	°	ADP
fnp-3049	111	12	c	c	NOUN
fnp-3049	111	13	in	in	ADP
fnp-3049	111	14	4	4	NUM
fnp-3049	111	15	%	%	NOUN
fnp-3049	111	16	pfa	pfa	NOUN
fnp-3049	111	17	and	and	CCONJ
fnp-3049	111	18	subsequently	subsequently	ADV
fnp-3049	111	19	placed	place	VERB
fnp-3049	111	20	in	in	ADP
fnp-3049	111	21	30	30	NUM
fnp-3049	111	22	%	%	NOUN
fnp-3049	111	23	sucrose	sucrose	NOUN
fnp-3049	111	24	.	.	PUNCT
fnp-3049	112	1	brains	brain	NOUN
fnp-3049	112	2	were	be	AUX
fnp-3049	112	3	frozen	frozen	ADJ
fnp-3049	112	4	and	and	CCONJ
fnp-3049	112	5	coronal	coronal	ADJ
fnp-3049	112	6	sections	section	NOUN
fnp-3049	112	7	of	of	ADP
fnp-3049	112	8	40	40	NUM
fnp-3049	112	9	μm	μm	NOUN
fnp-3049	112	10	were	be	AUX
fnp-3049	112	11	cut	cut	VERB
fnp-3049	112	12	on	on	ADP
fnp-3049	112	13	a	a	DET
fnp-3049	112	14	microtome	microtome	NOUN
fnp-3049	112	15	(	(	PUNCT
fnp-3049	112	16	leica	leica	PROPN
fnp-3049	112	17	)	)	PUNCT
fnp-3049	112	18	and	and	CCONJ
fnp-3049	112	19	collected	collect	VERB
fnp-3049	112	20	as	as	ADP
fnp-3049	112	21	serial	serial	ADJ
fnp-3049	112	22	tissue	tissue	NOUN
fnp-3049	112	23	sections	section	NOUN
fnp-3049	112	24	.	.	PUNCT
fnp-3049	113	1	for	for	ADP
fnp-3049	113	2	immunohistochemistry	immunohistochemistry	NOUN
fnp-3049	113	3	in	in	ADP
fnp-3049	113	4	mice	mouse	NOUN
fnp-3049	113	5	,	,	PUNCT
fnp-3049	113	6	a	a	DET
fnp-3049	113	7	series	series	NOUN
fnp-3049	113	8	(	(	PUNCT
fnp-3049	113	9	every	every	DET
fnp-3049	113	10	240	240	NUM
fnp-3049	113	11	μm	μm	NOUN
fnp-3049	113	12	)	)	PUNCT
fnp-3049	113	13	of	of	ADP
fnp-3049	113	14	coronal	coronal	ADJ
fnp-3049	113	15	free	free	ADV
fnp-3049	113	16	-	-	PUNCT
fnp-3049	113	17	floating	float	VERB
fnp-3049	113	18	sections	section	NOUN
fnp-3049	113	19	were	be	AUX
fnp-3049	113	20	stained	stain	VERB
fnp-3049	113	21	using	use	VERB
fnp-3049	113	22	1:10000	1:10000	NUM
fnp-3049	113	23	anti	anti	ADJ
fnp-3049	113	24	-	-	ADJ
fnp-3049	113	25	pser129	pser129	ADJ
fnp-3049	113	26	αsyn	αsyn	ADJ
fnp-3049	113	27	primary	primary	ADJ
fnp-3049	113	28	antibody	antibody	NOUN
fnp-3049	113	29	(	(	PUNCT
fnp-3049	113	30	abcam	abcam	NOUN
fnp-3049	113	31	,	,	PUNCT
fnp-3049	113	32	ab51253	ab51253	PROPN
fnp-3049	113	33	)	)	PUNCT
fnp-3049	113	34	,	,	PUNCT
fnp-3049	113	35	1:1000	1:1000	NUM
fnp-3049	113	36	anti	anti	ADJ
fnp-3049	113	37	-	-	ADJ
fnp-3049	113	38	neun	neun	ADJ
fnp-3049	113	39	primary	primary	ADJ
fnp-3049	113	40	antibody	antibody	NOUN
fnp-3049	113	41	(	(	PUNCT
fnp-3049	113	42	millipore	millipore	NOUN
fnp-3049	113	43	,	,	PUNCT
fnp-3049	113	44	ab377	ab377	PROPN
fnp-3049	113	45	)	)	PUNCT
fnp-3049	113	46	,	,	PUNCT
fnp-3049	113	47	1:5000	1:5000	NUM
fnp-3049	113	48	anti	anti	ADJ
fnp-3049	113	49	-	-	ADJ
fnp-3049	113	50	nitrated	nitrated	ADJ
fnp-3049	113	51	αsyn	αsyn	ADJ
fnp-3049	113	52	primary	primary	ADJ
fnp-3049	113	53	antibody	antibody	NOUN
fnp-3049	113	54	(	(	PUNCT
fnp-3049	113	55	thermo	thermo	NOUN
fnp-3049	113	56	fisher	fisher	PROPN
fnp-3049	113	57	,	,	PUNCT
fnp-3049	113	58	35	35	NUM
fnp-3049	113	59	-	-	SYM
fnp-3049	113	60	8300	8300	NUM
fnp-3049	113	61	)	)	PUNCT
fnp-3049	113	62	or	or	CCONJ
fnp-3049	113	63	1:800	1:800	NUM
fnp-3049	113	64	anti	anti	ADJ
fnp-3049	113	65	-	-	ADJ
fnp-3049	113	66	iba1	iba1	ADJ
fnp-3049	113	67	primary	primary	ADJ
fnp-3049	113	68	antibody	antibody	NOUN
fnp-3049	113	69	(	(	PUNCT
fnp-3049	113	70	wako	wako	PROPN
fnp-3049	113	71	,	,	PUNCT
fnp-3049	113	72	019	019	NUM
fnp-3049	113	73	-	-	SYM
fnp-3049	113	74	19741	19741	NUM
fnp-3049	113	75	)	)	PUNCT
fnp-3049	113	76	over	over	ADP
fnp-3049	113	77	night	night	NOUN
fnp-3049	113	78	.	.	PUNCT
fnp-3049	114	1	for	for	ADP
fnp-3049	114	2	immunohistochemistry	immunohistochemistry	NOUN
fnp-3049	114	3	in	in	ADP
fnp-3049	114	4	rats	rat	NOUN
fnp-3049	114	5	,	,	PUNCT
fnp-3049	114	6	a	a	DET
fnp-3049	114	7	series	series	NOUN
fnp-3049	114	8	(	(	PUNCT
fnp-3049	114	9	every	every	DET
fnp-3049	114	10	240	240	NUM
fnp-3049	114	11	μm	μm	NOUN
fnp-3049	114	12	)	)	PUNCT
fnp-3049	114	13	of	of	ADP
fnp-3049	114	14	coronal	coronal	ADJ
fnp-3049	114	15	free	free	ADV
fnp-3049	114	16	-	-	PUNCT
fnp-3049	114	17	floating	float	VERB
fnp-3049	114	18	sections	section	NOUN
fnp-3049	114	19	of	of	ADP
fnp-3049	114	20	sn	sn	PROPN
fnp-3049	114	21	was	be	AUX
fnp-3049	114	22	stained	stain	VERB
fnp-3049	114	23	using	use	VERB
fnp-3049	114	24	1:10000	1:10000	NUM
fnp-3049	114	25	anti	anti	ADJ
fnp-3049	114	26	-	-	ADJ
fnp-3049	114	27	pser129	pser129	ADJ
fnp-3049	114	28	αsyn	αsyn	ADJ
fnp-3049	114	29	primary	primary	ADJ
fnp-3049	114	30	antibody	antibody	NOUN
fnp-3049	114	31	(	(	PUNCT
fnp-3049	114	32	abcam	abcam	NOUN
fnp-3049	114	33	,	,	PUNCT
fnp-3049	114	34	ab51253	ab51253	PROPN
fnp-3049	114	35	)	)	PUNCT
fnp-3049	114	36	,	,	PUNCT
fnp-3049	114	37	1:5000	1:5000	NUM
fnp-3049	114	38	anti	anti	ADJ
fnp-3049	114	39	-	-	ADJ
fnp-3049	114	40	nitrated	nitrated	ADJ
fnp-3049	114	41	αsyn	αsyn	ADJ
fnp-3049	114	42	primary	primary	ADJ
fnp-3049	114	43	antibody	antibody	NOUN
fnp-3049	114	44	(	(	PUNCT
fnp-3049	114	45	thermo	thermo	NOUN
fnp-3049	114	46	fisher	fisher	PROPN
fnp-3049	114	47	,	,	PUNCT
fnp-3049	114	48	35	35	NUM
fnp-3049	114	49	-	-	SYM
fnp-3049	114	50	8300	8300	NUM
fnp-3049	114	51	)	)	PUNCT
fnp-3049	114	52	,	,	PUNCT
fnp-3049	114	53	1:2000	1:2000	NUM
fnp-3049	114	54	anti	anti	ADJ
fnp-3049	114	55	-	-	ADJ
fnp-3049	114	56	th	th	X
fnp-3049	114	57	(	(	PUNCT
fnp-3049	114	58	abcam	abcam	PROPN
fnp-3049	114	59	,	,	PUNCT
fnp-3049	114	60	ab137869	ab137869	PROPN
fnp-3049	114	61	)	)	PUNCT
fnp-3049	114	62	,	,	PUNCT
fnp-3049	114	63	or	or	CCONJ
fnp-3049	114	64	1:800	1:800	NUM
fnp-3049	114	65	anti	anti	ADJ
fnp-3049	114	66	-	-	ADJ
fnp-3049	114	67	iba1	iba1	ADJ
fnp-3049	114	68	primary	primary	ADJ
fnp-3049	114	69	antibody	antibody	NOUN
fnp-3049	114	70	(	(	PUNCT
fnp-3049	114	71	wako	wako	PROPN
fnp-3049	114	72	,	,	PUNCT
fnp-3049	114	73	019	019	NUM
fnp-3049	114	74	-	-	SYM
fnp-3049	114	75	19741	19741	NUM
fnp-3049	114	76	)	)	PUNCT
fnp-3049	114	77	overnight	overnight	ADV
fnp-3049	114	78	.	.	PUNCT
fnp-3049	115	1	corresponding	correspond	VERB
fnp-3049	115	2	secondary	secondary	ADJ
fnp-3049	115	3	antibodies	antibody	NOUN
fnp-3049	115	4	(	(	PUNCT
fnp-3049	115	5	1:500	1:500	NUM
fnp-3049	115	6	goat	goat	PROPN
fnp-3049	115	7	anti	anti	NOUN
fnp-3049	115	8	-	-	NOUN
fnp-3049	115	9	rabbit	rabbit	ADJ
fnp-3049	115	10	/	/	SYM
fnp-3049	115	11	goat	goat	NOUN
fnp-3049	115	12	anti	anti	PROPN
fnp-3049	115	13	-	-	ADJ
fnp-3049	115	14	mouse	mouse	ADJ
fnp-3049	115	15	biotinylated	biotinylated	ADJ
fnp-3049	115	16	secondary	secondary	ADJ
fnp-3049	115	17	antibody	antibody	NOUN
fnp-3049	115	18	(	(	PUNCT
fnp-3049	115	19	vector	vector	NOUN
fnp-3049	115	20	laboratories	laboratory	NOUN
fnp-3049	115	21	,	,	PUNCT
fnp-3049	115	22	ba-1000	ba-1000	NOUN
fnp-3049	115	23	and	and	CCONJ
fnp-3049	115	24	ba-9200	ba-9200	NOUN
fnp-3049	115	25	)	)	PUNCT
fnp-3049	115	26	were	be	AUX
fnp-3049	115	27	added	add	VERB
fnp-3049	115	28	.	.	PUNCT
fnp-3049	116	1	the	the	DET
fnp-3049	116	2	antibody	antibody	NOUN
fnp-3049	116	3	signal	signal	NOUN
fnp-3049	116	4	was	be	AUX
fnp-3049	116	5	amplified	amplify	VERB
fnp-3049	116	6	using	use	VERB
fnp-3049	116	7	a	a	DET
fnp-3049	116	8	standard	standard	ADJ
fnp-3049	116	9	peroxidase	peroxidase	NOUN
fnp-3049	116	10	-	-	PUNCT
fnp-3049	116	11	based	base	VERB
fnp-3049	116	12	method	method	NOUN
fnp-3049	116	13	(	(	PUNCT
fnp-3049	116	14	vectastain	vectastain	NOUN
fnp-3049	116	15	abc	abc	PROPN
fnp-3049	116	16	kit	kit	PROPN
fnp-3049	116	17	)	)	PUNCT
fnp-3049	116	18	and	and	CCONJ
fnp-3049	116	19	developed	develop	VERB
fnp-3049	116	20	using	use	VERB
fnp-3049	116	21	a	a	DET
fnp-3049	116	22	dab	dab	NOUN
fnp-3049	116	23	kit	kit	NOUN
fnp-3049	116	24	(	(	PUNCT
fnp-3049	116	25	vector	vector	NOUN
fnp-3049	116	26	laboratories	laboratory	NOUN
fnp-3049	116	27	)	)	PUNCT
fnp-3049	116	28	.	.	PUNCT
fnp-3049	117	1	immunostained	immunostaine	VERB
fnp-3049	117	2	tissue	tissue	NOUN
fnp-3049	117	3	sections	section	NOUN
fnp-3049	117	4	were	be	AUX
fnp-3049	117	5	mounted	mount	VERB
fnp-3049	117	6	onto	onto	ADP
fnp-3049	117	7	gelatin	gelatin	NOUN
fnp-3049	117	8	coated	coat	VERB
fnp-3049	117	9	glass	glass	NOUN
fnp-3049	117	10	slides	slide	NOUN
fnp-3049	117	11	.	.	PUNCT
fnp-3049	118	1	neunand	neunand	PROPN
fnp-3049	118	2	th	th	VERB
fnp-3049	118	3	-	-	PUNCT
fnp-3049	118	4	immunostained	immunostaine	VERB
fnp-3049	118	5	slides	slide	NOUN
fnp-3049	118	6	were	be	AUX
fnp-3049	118	7	counter	counter	ADV
fnp-3049	118	8	stained	stain	VERB
fnp-3049	118	9	with	with	ADP
fnp-3049	118	10	cresyl	cresyl	ADJ
fnp-3049	118	11	violet	violet	NOUN
fnp-3049	118	12	(	(	PUNCT
fnp-3049	118	13	cv	cv	PROPN
fnp-3049	118	14	)	)	PUNCT
fnp-3049	118	15	.	.	PUNCT
fnp-3049	119	1	after	after	ADP
fnp-3049	119	2	dehydration	dehydration	NOUN
fnp-3049	119	3	,	,	PUNCT
fnp-3049	119	4	slides	slide	NOUN
fnp-3049	119	5	were	be	AUX
fnp-3049	119	6	sealed	seal	VERB
fnp-3049	119	7	by	by	ADP
fnp-3049	119	8	coverslip	coverslip	NOUN
fnp-3049	119	9	with	with	ADP
fnp-3049	119	10	cytoseal	cytoseal	NOUN
fnp-3049	119	11	60	60	NUM
fnp-3049	119	12	mounting	mount	VERB
fnp-3049	119	13	medium	medium	NOUN
fnp-3049	119	14	(	(	PUNCT
fnp-3049	119	15	thermo	thermo	NOUN
fnp-3049	119	16	fisher	fisher	PROPN
fnp-3049	119	17	scientific	scientific	PROPN
fnp-3049	119	18	)	)	PUNCT
fnp-3049	119	19	.	.	PUNCT
fnp-3049	120	1	for	for	ADP
fnp-3049	120	2	lamp2	lamp2	PROPN
fnp-3049	120	3	immunostaining	immunostaine	VERB
fnp-3049	120	4	,	,	PUNCT
fnp-3049	120	5	using	use	VERB
fnp-3049	120	6	fluorescence	fluorescence	NOUN
fnp-3049	120	7	to	to	PART
fnp-3049	120	8	detect	detect	VERB
fnp-3049	120	9	antibody	antibody	NOUN
fnp-3049	120	10	binding	bind	VERB
fnp-3049	120	11	,	,	PUNCT
fnp-3049	120	12	sections	section	NOUN
fnp-3049	120	13	were	be	AUX
fnp-3049	120	14	incubated	incubate	VERB
fnp-3049	120	15	overnight	overnight	ADV
fnp-3049	120	16	with	with	ADP
fnp-3049	120	17	1:1000	1:1000	NUM
fnp-3049	120	18	anti	anti	ADJ
fnp-3049	120	19	-	-	ADJ
fnp-3049	120	20	lamp2	lamp2	ADJ
fnp-3049	120	21	primary	primary	ADJ
fnp-3049	120	22	antibody	antibody	NOUN
fnp-3049	120	23	(	(	PUNCT
fnp-3049	120	24	abcam	abcam	PROPN
fnp-3049	120	25	,	,	PUNCT
fnp-3049	120	26	ab13524	ab13524	PROPN
fnp-3049	120	27	)	)	PUNCT
fnp-3049	120	28	overnight	overnight	ADV
fnp-3049	120	29	,	,	PUNCT
fnp-3049	120	30	followed	follow	VERB
fnp-3049	120	31	by	by	ADP
fnp-3049	120	32	a	a	DET
fnp-3049	120	33	2	2	NUM
fnp-3049	120	34	h	h	NOUN
fnp-3049	120	35	incubation	incubation	NOUN
fnp-3049	120	36	with	with	ADP
fnp-3049	120	37	a	a	DET
fnp-3049	120	38	fluorescent	fluorescent	ADJ
fnp-3049	120	39	secondary	secondary	ADJ
fnp-3049	120	40	antibody	antibody	NOUN
fnp-3049	120	41	(	(	PUNCT
fnp-3049	120	42	thermo	thermo	NOUN
fnp-3049	120	43	fisher	fisher	PROPN
fnp-3049	120	44	/	/	SYM
fnp-3049	120	45	invitrogen	invitrogen	PROPN
fnp-3049	120	46	,	,	PUNCT
fnp-3049	120	47	alexa	alexa	NOUN
fnp-3049	120	48	fluor	fluor	NOUN
fnp-3049	120	49	488	488	NUM
fnp-3049	120	50	)	)	PUNCT
fnp-3049	120	51	.	.	PUNCT
fnp-3049	121	1	dapi	dapi	PROPN
fnp-3049	121	2	was	be	AUX
fnp-3049	121	3	used	use	VERB
fnp-3049	121	4	to	to	PART
fnp-3049	121	5	visualize	visualize	VERB
fnp-3049	121	6	cell	cell	NOUN
fnp-3049	121	7	nuclei	nucleus	NOUN
fnp-3049	121	8	.	.	PUNCT
fnp-3049	122	1	for	for	ADP
fnp-3049	122	2	the	the	DET
fnp-3049	122	3	co	co	NOUN
fnp-3049	122	4	-	-	NOUN
fnp-3049	122	5	stain	stain	NOUN
fnp-3049	122	6	between	between	ADP
fnp-3049	122	7	h	h	NOUN
fnp-3049	122	8	-	-	PUNCT
fnp-3049	122	9	ftaa	ftaa	ADJ
fnp-3049	122	10	and	and	CCONJ
fnp-3049	122	11	pser129	pser129	PROPN
fnp-3049	122	12	,	,	PUNCT
fnp-3049	122	13	tissue	tissue	NOUN
fnp-3049	122	14	sections	section	NOUN
fnp-3049	122	15	were	be	AUX
fnp-3049	122	16	incubated	incubate	VERB
fnp-3049	122	17	with	with	ADP
fnp-3049	122	18	1:1000	1:1000	NUM
fnp-3049	122	19	anti	anti	ADJ
fnp-3049	122	20	-	-	ADJ
fnp-3049	122	21	pser129	pser129	ADJ
fnp-3049	122	22	αsyn	αsyn	ADJ
fnp-3049	122	23	primary	primary	ADJ
fnp-3049	122	24	antibody	antibody	NOUN
fnp-3049	122	25	(	(	PUNCT
fnp-3049	122	26	abcam	abcam	NOUN
fnp-3049	122	27	,	,	PUNCT
fnp-3049	122	28	ab51253	ab51253	ADJ
fnp-3049	122	29	)	)	PUNCT
fnp-3049	122	30	for	for	ADP
fnp-3049	122	31	2h	2h	NUM
fnp-3049	122	32	at	at	ADP
fnp-3049	122	33	rt	rt	PROPN
fnp-3049	122	34	followed	follow	VERB
fnp-3049	122	35	by	by	ADP
fnp-3049	122	36	a	a	DET
fnp-3049	122	37	1h	1h	NUM
fnp-3049	122	38	incubation	incubation	NOUN
fnp-3049	122	39	with	with	ADP
fnp-3049	122	40	1:200	1:200	NUM
fnp-3049	122	41	secondary	secondary	ADJ
fnp-3049	122	42	goat	goat	PROPN
fnp-3049	122	43	anti	anti	ADJ
fnp-3049	122	44	-	-	ADJ
fnp-3049	122	45	rabbit	rabbit	ADJ
fnp-3049	122	46	antibody	antibody	NOUN
fnp-3049	122	47	alexa	alexa	NOUN
fnp-3049	122	48	647	647	NUM
fnp-3049	123	1	(	(	PUNCT
fnp-3049	123	2	thermo	thermo	NOUN
fnp-3049	123	3	fisher	fisher	PROPN
fnp-3049	123	4	,	,	PUNCT
fnp-3049	123	5	a32733	a32733	ADV
fnp-3049	123	6	)	)	PUNCT
fnp-3049	123	7	and	and	CCONJ
fnp-3049	123	8	dapi	dapi	ADJ
fnp-3049	123	9	to	to	PART
fnp-3049	123	10	visualize	visualize	VERB
fnp-3049	123	11	cell	cell	NOUN
fnp-3049	123	12	nuclei	nucleus	NOUN
fnp-3049	123	13	.	.	PUNCT
fnp-3049	124	1	finally	finally	ADV
fnp-3049	124	2	,	,	PUNCT
fnp-3049	124	3	0.5	0.5	NUM
fnp-3049	124	4	μm	μm	NOUN
fnp-3049	124	5	h	h	NOUN
fnp-3049	124	6	-	-	PUNCT
fnp-3049	124	7	ftaa	ftaa	PROPN
fnp-3049	124	8	was	be	AUX
fnp-3049	124	9	added	add	VERB
fnp-3049	124	10	and	and	CCONJ
fnp-3049	124	11	allowed	allow	VERB
fnp-3049	124	12	to	to	PART
fnp-3049	124	13	incubate	incubate	VERB
fnp-3049	124	14	with	with	ADP
fnp-3049	124	15	the	the	DET
fnp-3049	124	16	tissue	tissue	NOUN
fnp-3049	124	17	for	for	ADP
fnp-3049	124	18	30	30	NUM
fnp-3049	124	19	min	min	NOUN
fnp-3049	124	20	at	at	ADP
fnp-3049	124	21	rt	rt	PROPN
fnp-3049	124	22	.	.	PUNCT
fnp-3049	124	23	fluorescently	fluorescently	ADV
fnp-3049	124	24	stained	stain	VERB
fnp-3049	124	25	tissue	tissue	NOUN
fnp-3049	124	26	was	be	AUX
fnp-3049	124	27	sealed	seal	VERB
fnp-3049	124	28	by	by	ADP
fnp-3049	124	29	coverslip	coverslip	NOUN
fnp-3049	124	30	using	use	VERB
fnp-3049	124	31	hard	hard	ADV
fnp-3049	124	32	-	-	PUNCT
fnp-3049	124	33	set	set	VERB
fnp-3049	124	34	antifade	antifade	NOUN
fnp-3049	124	35	mounting	mount	VERB
fnp-3049	124	36	media	medium	NOUN
fnp-3049	124	37	(	(	PUNCT
fnp-3049	124	38	vector	vector	NOUN
fnp-3049	124	39	laboratories	laboratory	NOUN
fnp-3049	124	40	,	,	PUNCT
fnp-3049	124	41	h-1400	h-1400	PROPN
fnp-3049	124	42	)	)	PUNCT
fnp-3049	124	43	.	.	PUNCT
fnp-3049	125	1	a	a	DET
fnp-3049	125	2	nikon	nikon	PROPN
fnp-3049	125	3	a1plus	a1plus	ADJ
fnp-3049	125	4	-	-	PUNCT
fnp-3049	125	5	rsi	rsi	NOUN
fnp-3049	125	6	laser	laser	NOUN
fnp-3049	125	7	scanning	scan	VERB
fnp-3049	125	8	confocal	confocal	ADJ
fnp-3049	125	9	microscope	microscope	NOUN
fnp-3049	125	10	(	(	PUNCT
fnp-3049	125	11	nikon	nikon	PROPN
fnp-3049	125	12	)	)	PUNCT
fnp-3049	125	13	was	be	AUX
fnp-3049	125	14	used	use	VERB
fnp-3049	125	15	to	to	PART
fnp-3049	125	16	image	image	VERB
fnp-3049	125	17	these	these	DET
fnp-3049	125	18	sections	section	NOUN
fnp-3049	125	19	.	.	PUNCT
fnp-3049	126	1	pser129	pser129	PROPN
fnp-3049	126	2	quantification	quantification	NOUN
fnp-3049	126	3	z	z	NOUN
fnp-3049	126	4	-	-	PUNCT
fnp-3049	126	5	stacks	stack	NOUN
fnp-3049	126	6	of	of	ADP
fnp-3049	126	7	mounted	mount	VERB
fnp-3049	126	8	αsyn	αsyn	ADJ
fnp-3049	126	9	pser129	pser129	ADJ
fnp-3049	126	10	-	-	PUNCT
fnp-3049	126	11	stained	stain	VERB
fnp-3049	126	12	tissue	tissue	NOUN
fnp-3049	126	13	sections	section	NOUN
fnp-3049	126	14	were	be	AUX
fnp-3049	126	15	captured	capture	VERB
fnp-3049	126	16	at	at	ADP
fnp-3049	126	17	20x	20x	NOUN
fnp-3049	126	18	magnification	magnification	NOUN
fnp-3049	126	19	using	use	VERB
fnp-3049	126	20	a	a	DET
fnp-3049	126	21	whole	whole	ADJ
fnp-3049	126	22	slide	slide	NOUN
fnp-3049	126	23	scanner	scanner	NOUN
fnp-3049	126	24	(	(	PUNCT
fnp-3049	126	25	zeiss	zeiss	PROPN
fnp-3049	126	26	,	,	PUNCT
fnp-3049	126	27	axioscan	axioscan	ADJ
fnp-3049	126	28	z1	z1	PROPN
fnp-3049	126	29	)	)	PUNCT
fnp-3049	126	30	at	at	ADP
fnp-3049	126	31	a	a	DET
fnp-3049	126	32	0.22	0.22	NUM
fnp-3049	126	33	μm	μm	NUM
fnp-3049	126	34	/	/	SYM
fnp-3049	126	35	pixel	pixel	NOUN
fnp-3049	126	36	resolution	resolution	NOUN
fnp-3049	126	37	.	.	PUNCT
fnp-3049	127	1	extended	extend	VERB
fnp-3049	127	2	depth	depth	NOUN
fnp-3049	127	3	focus	focus	NOUN
fnp-3049	127	4	(	(	PUNCT
fnp-3049	127	5	edf	edf	PROPN
fnp-3049	127	6	)	)	PUNCT
fnp-3049	127	7	was	be	AUX
fnp-3049	127	8	used	use	VERB
fnp-3049	127	9	to	to	PART
fnp-3049	127	10	collapse	collapse	VERB
fnp-3049	127	11	the	the	DET
fnp-3049	127	12	z	z	NOUN
fnp-3049	127	13	-	-	PUNCT
fnp-3049	127	14	stacks	stack	NOUN
fnp-3049	127	15	into	into	ADP
fnp-3049	127	16	2d	2d	NUM
fnp-3049	127	17	images	image	NOUN
fnp-3049	127	18	as	as	SCONJ
fnp-3049	127	19	they	they	PRON
fnp-3049	127	20	were	be	AUX
fnp-3049	127	21	collected	collect	VERB
fnp-3049	127	22	.	.	PUNCT
fnp-3049	128	1	tissue	tissue	NOUN
fnp-3049	128	2	thickness	thickness	NOUN
fnp-3049	128	3	was	be	AUX
fnp-3049	128	4	set	set	VERB
fnp-3049	128	5	to	to	ADP
fnp-3049	128	6	20	20	NUM
fnp-3049	128	7	μm	μm	NUM
fnp-3049	128	8	,	,	PUNCT
fnp-3049	128	9	z	z	NOUN
fnp-3049	128	10	-	-	PUNCT
fnp-3049	128	11	stacks	stack	NOUN
fnp-3049	128	12	were	be	AUX
fnp-3049	128	13	collected	collect	VERB
fnp-3049	128	14	at	at	ADP
fnp-3049	128	15	3	3	NUM
fnp-3049	128	16	μm	μm	NOUN
fnp-3049	128	17	intervals	interval	NOUN
fnp-3049	128	18	and	and	CCONJ
fnp-3049	128	19	the	the	DET
fnp-3049	128	20	method	method	NOUN
fnp-3049	128	21	used	use	VERB
fnp-3049	128	22	was	be	AUX
fnp-3049	128	23	contrast	contrast	NOUN
fnp-3049	128	24	.	.	PUNCT
fnp-3049	129	1	the	the	DET
fnp-3049	129	2	images	image	NOUN
fnp-3049	129	3	were	be	AUX
fnp-3049	129	4	exported	export	VERB
fnp-3049	129	5	with	with	ADP
fnp-3049	129	6	85	85	NUM
fnp-3049	129	7	%	%	NOUN
fnp-3049	129	8	compression	compression	NOUN
fnp-3049	129	9	as	as	ADP
fnp-3049	129	10	.jpeg	.jpeg	ADP
fnp-3049	129	11	files	file	NOUN
fnp-3049	129	12	.	.	PUNCT
fnp-3049	130	1	the	the	DET
fnp-3049	130	2	digitized	digitize	VERB
fnp-3049	130	3	images	image	NOUN
fnp-3049	130	4	were	be	AUX
fnp-3049	130	5	then	then	ADV
fnp-3049	130	6	uploaded	upload	VERB
fnp-3049	130	7	aiforia	aiforia	ADJ
fnp-3049	130	8	™	™	ADJ
fnp-3049	130	9	image	image	NOUN
fnp-3049	130	10	processing	processing	NOUN
fnp-3049	130	11	and	and	CCONJ
fnp-3049	130	12	management	management	NOUN
fnp-3049	130	13	platform	platform	NOUN
fnp-3049	130	14	(	(	PUNCT
fnp-3049	130	15	aiforia	aiforia	PROPN
fnp-3049	130	16	technologies	technology	NOUN
fnp-3049	130	17	,	,	PUNCT
fnp-3049	130	18	helsinki	helsinki	PROPN
fnp-3049	130	19	,	,	PUNCT
fnp-3049	130	20	finland	finland	PROPN
fnp-3049	130	21	)	)	PUNCT
fnp-3049	130	22	for	for	ADP
fnp-3049	130	23	analysis	analysis	NOUN
fnp-3049	130	24	with	with	ADP
fnp-3049	130	25	deep	deep	ADJ
fnp-3049	130	26	learning	learning	NOUN
fnp-3049	130	27	convolution	convolution	NOUN
fnp-3049	130	28	neural	neural	ADJ
fnp-3049	130	29	networks	network	NOUN
fnp-3049	130	30	(	(	PUNCT
fnp-3049	130	31	cnns	cnns	PROPN
fnp-3049	130	32	)	)	PUNCT
fnp-3049	130	33	and	and	CCONJ
fnp-3049	130	34	supervised	supervised	ADJ
fnp-3049	130	35	learning	learning	NOUN
fnp-3049	130	36	.	.	PUNCT
fnp-3049	131	1	a	a	DET
fnp-3049	131	2	supervised	supervised	ADJ
fnp-3049	131	3	,	,	PUNCT
fnp-3049	131	4	multi	multi	ADJ
fnp-3049	131	5	-	-	ADJ
fnp-3049	131	6	layered	layered	ADJ
fnp-3049	131	7	,	,	PUNCT
fnp-3049	131	8	cnn	cnn	PROPN
fnp-3049	131	9	was	be	AUX
fnp-3049	131	10	trained	train	VERB
fnp-3049	131	11	on	on	ADP
fnp-3049	131	12	annotations	annotation	NOUN
fnp-3049	131	13	from	from	ADP
fnp-3049	131	14	digitized	digitize	VERB
fnp-3049	131	15	αsyn	αsyn	ADJ
fnp-3049	131	16	pser129	pser129	PROPN
fnp-3049	131	17	-	-	PUNCT
fnp-3049	131	18	stained	stain	VERB
fnp-3049	131	19	coronal	coronal	ADJ
fnp-3049	131	20	slices	slice	NOUN
fnp-3049	131	21	to	to	PART
fnp-3049	131	22	recognize	recognize	VERB
fnp-3049	131	23	total	total	ADJ
fnp-3049	131	24	αsyn	αsyn	NOUN
fnp-3049	131	25	-	-	PUNCT
fnp-3049	131	26	positive	positive	ADJ
fnp-3049	131	27	staining	staining	NOUN
fnp-3049	131	28	.	.	PUNCT
fnp-3049	132	1	the	the	DET
fnp-3049	132	2	algorithm	algorithm	NOUN
fnp-3049	132	3	was	be	AUX
fnp-3049	132	4	trained	train	VERB
fnp-3049	132	5	on	on	ADP
fnp-3049	132	6	the	the	DET
fnp-3049	132	7	most	most	ADV
fnp-3049	132	8	diverse	diverse	ADJ
fnp-3049	132	9	and	and	CCONJ
fnp-3049	132	10	representative	representative	ADJ
fnp-3049	132	11	images	image	NOUN
fnp-3049	132	12	from	from	ADP
fnp-3049	132	13	across	across	ADP
fnp-3049	132	14	multiple	multiple	ADJ
fnp-3049	132	15	pser129	pser129	PROPN
fnp-3049	132	16	datasets	dataset	NOUN
fnp-3049	132	17	to	to	PART
fnp-3049	132	18	create	create	VERB
fnp-3049	132	19	a	a	DET
fnp-3049	132	20	generalizable	generalizable	ADJ
fnp-3049	132	21	ai	ai	NOUN
fnp-3049	132	22	model	model	NOUN
fnp-3049	132	23	capable	capable	ADJ
fnp-3049	132	24	to	to	PART
fnp-3049	132	25	accurately	accurately	ADV
fnp-3049	132	26	detecting	detect	VERB
fnp-3049	132	27	αsyn	αsyn	ADJ
fnp-3049	132	28	pser129	pser129	ADJ
fnp-3049	132	29	-	-	PUNCT
fnp-3049	132	30	stained	stain	VERB
fnp-3049	132	31	profiles	profile	NOUN
fnp-3049	132	32	in	in	ADP
fnp-3049	132	33	slides	slide	NOUN
fnp-3049	132	34	collected	collect	VERB
fnp-3049	132	35	by	by	ADP
fnp-3049	132	36	multiple	multiple	ADJ
fnp-3049	132	37	investigators	investigator	NOUN
fnp-3049	132	38	.	.	PUNCT
fnp-3049	133	1	ninety	ninety	NUM
fnp-3049	133	2	-	-	PUNCT
fnp-3049	133	3	one	one	NUM
fnp-3049	133	4	images	image	NOUN
fnp-3049	133	5	constituted	constitute	VERB
fnp-3049	133	6	training	training	NOUN
fnp-3049	133	7	data	datum	NOUN
fnp-3049	133	8	.	.	PUNCT
fnp-3049	134	1	the	the	DET
fnp-3049	134	2	ground	ground	NOUN
fnp-3049	134	3	truth	truth	NOUN
fnp-3049	134	4	,	,	PUNCT
fnp-3049	134	5	or	or	CCONJ
fnp-3049	134	6	features	feature	NOUN
fnp-3049	134	7	of	of	ADP
fnp-3049	134	8	interest	interest	NOUN
fnp-3049	134	9	used	use	VERB
fnp-3049	134	10	to	to	PART
fnp-3049	134	11	train	train	VERB
fnp-3049	134	12	the	the	DET
fnp-3049	134	13	ai	ai	NOUN
fnp-3049	134	14	model	model	NOUN
fnp-3049	134	15	,	,	PUNCT
fnp-3049	134	16	were	be	AUX
fnp-3049	134	17	annotated	annotate	VERB
fnp-3049	134	18	for	for	ADP
fnp-3049	134	19	each	each	DET
fnp-3049	134	20	layer	layer	NOUN
fnp-3049	134	21	within	within	ADP
fnp-3049	134	22	the	the	DET
fnp-3049	134	23	aiforia	aiforia	ADJ
fnp-3049	134	24	™	™	ADJ
fnp-3049	134	25	cloud	cloud	NOUN
fnp-3049	134	26	platform	platform	NOUN
fnp-3049	134	27	and	and	CCONJ
fnp-3049	134	28	constituted	constitute	VERB
fnp-3049	134	29	input	input	NOUN
fnp-3049	134	30	data	datum	NOUN
fnp-3049	134	31	for	for	ADP
fnp-3049	134	32	each	each	DET
fnp-3049	134	33	cnn	cnn	PROPN
fnp-3049	134	34	.	.	PUNCT
fnp-3049	135	1	the	the	DET
fnp-3049	135	2	first	first	ADJ
fnp-3049	135	3	feature	feature	NOUN
fnp-3049	135	4	layer	layer	NOUN
fnp-3049	135	5	was	be	AUX
fnp-3049	135	6	annotated	annotate	VERB
fnp-3049	135	7	using	use	VERB
fnp-3049	135	8	semantic	semantic	ADJ
fnp-3049	135	9	segmentation	segmentation	NOUN
fnp-3049	135	10	to	to	PART
fnp-3049	135	11	distinguish	distinguish	VERB
fnp-3049	135	12	the	the	DET
fnp-3049	135	13	total	total	ADJ
fnp-3049	135	14	tissue	tissue	NOUN
fnp-3049	135	15	from	from	ADP
fnp-3049	135	16	the	the	DET
fnp-3049	135	17	glass	glass	NOUN
fnp-3049	135	18	slide	slide	NOUN
fnp-3049	135	19	.	.	PUNCT
fnp-3049	136	1	the	the	DET
fnp-3049	136	2	second	second	ADJ
fnp-3049	136	3	feature	feature	NOUN
fnp-3049	136	4	layer	layer	NOUN
fnp-3049	136	5	was	be	AUX
fnp-3049	136	6	annotated	annotate	VERB
fnp-3049	136	7	using	use	VERB
fnp-3049	136	8	semantic	semantic	ADJ
fnp-3049	136	9	segmentation	segmentation	NOUN
fnp-3049	136	10	to	to	PART
fnp-3049	136	11	distinguish	distinguish	VERB
fnp-3049	136	12	total	total	ADJ
fnp-3049	136	13	αsyn	αsyn	ADJ
fnp-3049	136	14	pser129	pser129	ADJ
fnp-3049	136	15	-	-	ADJ
fnp-3049	136	16	positive	positive	ADJ
fnp-3049	136	17	staining	staining	NOUN
fnp-3049	136	18	.	.	PUNCT
fnp-3049	137	1	features	feature	NOUN
fnp-3049	137	2	that	that	PRON
fnp-3049	137	3	were	be	AUX
fnp-3049	137	4	considered	consider	VERB
fnp-3049	137	5	artifact	artifact	ADJ
fnp-3049	137	6	(	(	PUNCT
fnp-3049	137	7	glass	glass	NOUN
fnp-3049	137	8	slide	slide	NOUN
fnp-3049	137	9	,	,	PUNCT
fnp-3049	137	10	debris	debris	NOUN
fnp-3049	137	11	)	)	PUNCT
fnp-3049	137	12	were	be	AUX
fnp-3049	137	13	annotated	annotate	VERB
fnp-3049	137	14	as	as	ADP
fnp-3049	137	15	background	background	NOUN
fnp-3049	137	16	,	,	PUNCT
fnp-3049	137	17	and	and	CCONJ
fnp-3049	137	18	constituted	constitute	VERB
fnp-3049	137	19	additional	additional	ADJ
fnp-3049	137	20	input	input	NOUN
fnp-3049	137	21	training	training	NOUN
fnp-3049	137	22	data	datum	NOUN
fnp-3049	137	23	for	for	ADP
fnp-3049	137	24	the	the	DET
fnp-3049	137	25	multi	multi	ADJ
fnp-3049	137	26	-	-	ADJ
fnp-3049	137	27	layered	layered	ADJ
fnp-3049	137	28	cnn	cnn	NOUN
fnp-3049	137	29	.	.	PUNCT
fnp-3049	138	1	the	the	DET
fnp-3049	138	2	regions	region	NOUN
fnp-3049	138	3	corresponding	correspond	VERB
fnp-3049	138	4	to	to	ADP
fnp-3049	138	5	the	the	DET
fnp-3049	138	6	aon	aon	PROPN
fnp-3049	138	7	and	and	CCONJ
fnp-3049	138	8	the	the	DET
fnp-3049	138	9	prh	prh	NOUN
fnp-3049	138	10	were	be	AUX
fnp-3049	138	11	outlined	outline	VERB
fnp-3049	138	12	according	accord	VERB
fnp-3049	138	13	to	to	ADP
fnp-3049	138	14	the	the	DET
fnp-3049	138	15	allen	allen	PROPN
fnp-3049	138	16	mouse	mouse	PROPN
fnp-3049	138	17	brain	brain	PROPN
fnp-3049	138	18	atlas	atlas	PROPN
fnp-3049	138	19	(	(	PUNCT
fnp-3049	138	20	allen	allen	PROPN
fnp-3049	138	21	institute	institute	PROPN
fnp-3049	138	22	)	)	PUNCT
fnp-3049	138	23	and	and	CCONJ
fnp-3049	138	24	the	the	DET
fnp-3049	138	25	cnn	cnn	PROPN
fnp-3049	138	26	was	be	AUX
fnp-3049	138	27	used	use	VERB
fnp-3049	138	28	to	to	PART
fnp-3049	138	29	quantify	quantify	VERB
fnp-3049	138	30	the	the	DET
fnp-3049	138	31	area	area	NOUN
fnp-3049	138	32	percentage	percentage	NOUN
fnp-3049	138	33	that	that	PRON
fnp-3049	138	34	contained	contain	VERB
fnp-3049	138	35	αsyn	αsyn	ADJ
fnp-3049	138	36	pser129	pser129	ADJ
fnp-3049	138	37	-	-	ADJ
fnp-3049	138	38	positive	positive	ADJ
fnp-3049	138	39	signal	signal	NOUN
fnp-3049	138	40	.	.	PUNCT
fnp-3049	139	1	for	for	ADP
fnp-3049	139	2	each	each	DET
fnp-3049	139	3	brain	brain	NOUN
fnp-3049	139	4	region	region	NOUN
fnp-3049	139	5	,	,	PUNCT
fnp-3049	139	6	the	the	DET
fnp-3049	139	7	average	average	ADJ
fnp-3049	139	8	area	area	NOUN
fnp-3049	139	9	with	with	ADP
fnp-3049	139	10	αsyn	αsyn	ADJ
fnp-3049	139	11	pser129	pser129	PROPN
fnp-3049	139	12	-	-	PUNCT
fnp-3049	139	13	staining	staining	NOUN
fnp-3049	139	14	is	be	AUX
fnp-3049	139	15	reported	report	VERB
fnp-3049	139	16	as	as	ADP
fnp-3049	139	17	a	a	DET
fnp-3049	139	18	percentage	percentage	NOUN
fnp-3049	139	19	of	of	ADP
fnp-3049	139	20	the	the	DET
fnp-3049	139	21	whole	whole	ADJ
fnp-3049	139	22	area	area	NOUN
fnp-3049	139	23	assayed	assay	VERB
fnp-3049	139	24	.	.	PUNCT
fnp-3049	140	1	for	for	ADP
fnp-3049	140	2	the	the	DET
fnp-3049	140	3	one	one	NUM
fnp-3049	140	4	-	-	PUNCT
fnp-3049	140	5	month	month	NOUN
fnp-3049	140	6	time	time	NOUN
fnp-3049	140	7	point	point	NOUN
fnp-3049	140	8	,	,	PUNCT
fnp-3049	140	9	six	six	NUM
fnp-3049	140	10	animals	animal	NOUN
fnp-3049	140	11	per	per	ADP
fnp-3049	140	12	group	group	NOUN
fnp-3049	140	13	were	be	AUX
fnp-3049	140	14	analyzed	analyze	VERB
fnp-3049	140	15	and	and	CCONJ
fnp-3049	140	16	for	for	ADP
fnp-3049	140	17	the	the	DET
fnp-3049	140	18	three	three	NUM
fnp-3049	140	19	-	-	PUNCT
fnp-3049	140	20	month	month	NOUN
fnp-3049	140	21	time	time	NOUN
fnp-3049	140	22	point	point	NOUN
fnp-3049	140	23	seven	seven	NUM
fnp-3049	140	24	to	to	PART
fnp-3049	140	25	eight	eight	NUM
fnp-3049	140	26	animals	animal	NOUN
fnp-3049	140	27	per	per	ADP
fnp-3049	140	28	group	group	NOUN
fnp-3049	140	29	were	be	AUX
fnp-3049	140	30	included	include	VERB
fnp-3049	140	31	in	in	ADP
fnp-3049	140	32	the	the	DET
fnp-3049	140	33	analysis	analysis	NOUN
fnp-3049	140	34	.	.	PUNCT
fnp-3049	141	1	stereology	stereology	NOUN
fnp-3049	141	2	surviving	survive	VERB
fnp-3049	141	3	dopamine	dopamine	NOUN
fnp-3049	141	4	neurons	neuron	NOUN
fnp-3049	141	5	and	and	CCONJ
fnp-3049	141	6	total	total	ADJ
fnp-3049	141	7	neuronal	neuronal	ADJ
fnp-3049	141	8	cell	cell	NOUN
fnp-3049	141	9	counts	count	NOUN
fnp-3049	141	10	were	be	AUX
fnp-3049	141	11	quantified	quantify	VERB
fnp-3049	141	12	using	use	VERB
fnp-3049	141	13	unbiased	unbiased	ADJ
fnp-3049	141	14	sampling	sampling	NOUN
fnp-3049	141	15	and	and	CCONJ
fnp-3049	141	16	blinded	blind	VERB
fnp-3049	141	17	stereology	stereology	NOUN
fnp-3049	141	18	.	.	PUNCT
fnp-3049	142	1	for	for	ADP
fnp-3049	142	2	the	the	DET
fnp-3049	142	3	aav	aav	PROPN
fnp-3049	142	4	αsyn	αsyn	PROPN
fnp-3049	142	5	over	over	ADP
fnp-3049	142	6	-	-	PUNCT
fnp-3049	142	7	expression	expression	NOUN
fnp-3049	142	8	model	model	NOUN
fnp-3049	142	9	,	,	PUNCT
fnp-3049	142	10	tyrosine	tyrosine	NOUN
fnp-3049	142	11	hydroxylase	hydroxylase	NOUN
fnp-3049	142	12	(	(	PUNCT
fnp-3049	142	13	th	th	NOUN
fnp-3049	142	14	)	)	PUNCT
fnp-3049	142	15	,	,	PUNCT
fnp-3049	142	16	αsyn	αsyn	PROPN
fnp-3049	142	17	pser129	pser129	PROPN
fnp-3049	142	18	and	and	CCONJ
fnp-3049	142	19	nitrated	nitrate	VERB
fnp-3049	142	20	αsyn	αsyn	NOUN
fnp-3049	142	21	-	-	PUNCT
fnp-3049	142	22	positive	positive	ADJ
fnp-3049	142	23	cells	cell	NOUN
fnp-3049	142	24	were	be	AUX
fnp-3049	142	25	counted	count	VERB
fnp-3049	142	26	in	in	ADP
fnp-3049	142	27	the	the	DET
fnp-3049	142	28	snpc	snpc	NOUN
fnp-3049	142	29	and	and	CCONJ
fnp-3049	142	30	snpr	snpr	NOUN
fnp-3049	142	31	in	in	ADP
fnp-3049	142	32	a	a	DET
fnp-3049	142	33	series	series	NOUN
fnp-3049	142	34	of	of	ADP
fnp-3049	142	35	seven	seven	NUM
fnp-3049	142	36	sections	section	NOUN
fnp-3049	142	37	at	at	ADP
fnp-3049	142	38	an	an	DET
fnp-3049	142	39	interval	interval	NOUN
fnp-3049	142	40	of	of	ADP
fnp-3049	142	41	six	six	NUM
fnp-3049	142	42	sections	section	NOUN
fnp-3049	142	43	at	at	ADP
fnp-3049	142	44	40	40	NUM
fnp-3049	142	45	μm	μm	NUM
fnp-3049	142	46	thickness	thickness	NOUN
fnp-3049	142	47	(	(	PUNCT
fnp-3049	142	48	240	240	NUM
fnp-3049	142	49	μm	μm	NUM
fnp-3049	142	50	intervals	interval	NOUN
fnp-3049	142	51	)	)	PUNCT
fnp-3049	142	52	.	.	PUNCT
fnp-3049	143	1	contours	contours	NOUN
fnp-3049	143	2	of	of	ADP
fnp-3049	143	3	the	the	DET
fnp-3049	143	4	regions	region	NOUN
fnp-3049	143	5	were	be	AUX
fnp-3049	143	6	drawn	draw	VERB
fnp-3049	143	7	at	at	ADP
fnp-3049	143	8	10x	10x	NOUN
fnp-3049	143	9	magnification	magnification	NOUN
fnp-3049	143	10	and	and	CCONJ
fnp-3049	143	11	quantifications	quantification	NOUN
fnp-3049	143	12	were	be	AUX
fnp-3049	143	13	performed	perform	VERB
fnp-3049	143	14	at	at	ADP
fnp-3049	143	15	60x	60x	NOUN
fnp-3049	143	16	using	use	VERB
fnp-3049	143	17	a	a	DET
fnp-3049	143	18	200	200	NUM
fnp-3049	143	19	μm	μm	ADJ
fnp-3049	143	20	counting	counting	NOUN
fnp-3049	143	21	frame	frame	NOUN
fnp-3049	143	22	.	.	PUNCT
fnp-3049	144	1	dissector	dissector	NOUN
fnp-3049	144	2	height	height	NOUN
fnp-3049	144	3	was	be	AUX
fnp-3049	144	4	12	12	NUM
fnp-3049	144	5	μm	μm	NOUN
fnp-3049	144	6	with	with	ADP
fnp-3049	144	7	a	a	DET
fnp-3049	144	8	3	3	NUM
fnp-3049	144	9	μm	μm	NOUN
fnp-3049	144	10	guard	guard	NOUN
fnp-3049	144	11	zone	zone	NOUN
fnp-3049	144	12	.	.	PUNCT
fnp-3049	145	1	the	the	DET
fnp-3049	145	2	gunderson	gunderson	PROPN
fnp-3049	145	3	estimated	estimate	VERB
fnp-3049	145	4	m=1	m=1	PUNCT
fnp-3049	145	5	error	error	NOUN
fnp-3049	145	6	was	be	AUX
fnp-3049	145	7	less	less	ADJ
fnp-3049	145	8	than	than	ADP
fnp-3049	145	9	0.1	0.1	NUM
fnp-3049	145	10	and	and	CCONJ
fnp-3049	145	11	a	a	DET
fnp-3049	145	12	total	total	NOUN
fnp-3049	145	13	of	of	ADP
fnp-3049	145	14	eight	eight	NUM
fnp-3049	145	15	animals	animal	NOUN
fnp-3049	145	16	per	per	ADP
fnp-3049	145	17	group	group	NOUN
fnp-3049	145	18	was	be	AUX
fnp-3049	145	19	counted	count	VERB
fnp-3049	145	20	.	.	PUNCT
fnp-3049	146	1	for	for	ADP
fnp-3049	146	2	the	the	DET
fnp-3049	146	3	αsyn	αsyn	PROPN
fnp-3049	146	4	pff	pff	PROPN
fnp-3049	146	5	seeding	seed	VERB
fnp-3049	146	6	model	model	NOUN
fnp-3049	146	7	,	,	PUNCT
fnp-3049	146	8	neunand	neunand	CCONJ
fnp-3049	146	9	cv	cv	ADJ
fnp-3049	146	10	-	-	ADJ
fnp-3049	146	11	positive	positive	ADJ
fnp-3049	146	12	cells	cell	NOUN
fnp-3049	146	13	were	be	AUX
fnp-3049	146	14	counted	count	VERB
fnp-3049	146	15	in	in	ADP
fnp-3049	146	16	the	the	DET
fnp-3049	146	17	aon	aon	PROPN
fnp-3049	146	18	,	,	PUNCT
fnp-3049	146	19	which	which	PRON
fnp-3049	146	20	was	be	AUX
fnp-3049	146	21	outlined	outline	VERB
fnp-3049	146	22	according	accord	VERB
fnp-3049	146	23	to	to	ADP
fnp-3049	146	24	the	the	DET
fnp-3049	146	25	allen	allen	PROPN
fnp-3049	146	26	mouse	mouse	PROPN
fnp-3049	146	27	brain	brain	PROPN
fnp-3049	146	28	atlas	atlas	PROPN
fnp-3049	146	29	(	(	PUNCT
fnp-3049	146	30	allen	allen	PROPN
fnp-3049	146	31	institute	institute	PROPN
fnp-3049	146	32	)	)	PUNCT
fnp-3049	146	33	using	use	VERB
fnp-3049	146	34	a	a	DET
fnp-3049	146	35	2.5x	2.5x	NUM
fnp-3049	146	36	objective	objective	NOUN
fnp-3049	146	37	.	.	PUNCT
fnp-3049	147	1	the	the	DET
fnp-3049	147	2	quantification	quantification	NOUN
fnp-3049	147	3	of	of	ADP
fnp-3049	147	4	neun	neun	NOUN
fnp-3049	147	5	and	and	CCONJ
fnp-3049	147	6	cv	cv	ADJ
fnp-3049	147	7	-	-	ADJ
fnp-3049	147	8	positive	positive	ADJ
fnp-3049	147	9	cells	cell	NOUN
fnp-3049	147	10	was	be	AUX
fnp-3049	147	11	performed	perform	VERB
fnp-3049	147	12	on	on	ADP
fnp-3049	147	13	every	every	DET
fnp-3049	147	14	6th	6th	ADJ
fnp-3049	147	15	aon	aon	PROPN
fnp-3049	147	16	(	(	PUNCT
fnp-3049	147	17	240	240	NUM
fnp-3049	147	18	μm	μm	NOUN
fnp-3049	147	19	)	)	PUNCT
fnp-3049	147	20	section	section	NOUN
fnp-3049	147	21	using	use	VERB
fnp-3049	147	22	the	the	DET
fnp-3049	147	23	optical	optical	ADJ
fnp-3049	147	24	fractionator	fractionator	NOUN
fnp-3049	147	25	probe	probe	NOUN
fnp-3049	147	26	in	in	ADP
fnp-3049	147	27	stereo	stereo	NOUN
fnp-3049	147	28	investigator	investigator	NOUN
fnp-3049	147	29	software	software	NOUN
fnp-3049	147	30	(	(	PUNCT
fnp-3049	147	31	mbf	mbf	NOUN
fnp-3049	147	32	bioscience	bioscience	NOUN
fnp-3049	147	33	)	)	PUNCT
fnp-3049	147	34	.	.	PUNCT
fnp-3049	148	1	the	the	DET
fnp-3049	148	2	counting	counting	NOUN
fnp-3049	148	3	was	be	AUX
fnp-3049	148	4	accomplished	accomplish	VERB
fnp-3049	148	5	using	use	VERB
fnp-3049	148	6	a	a	DET
fnp-3049	148	7	60x	60x	NUM
fnp-3049	148	8	oil	oil	NOUN
fnp-3049	148	9	objective	objective	NOUN
fnp-3049	148	10	,	,	PUNCT
fnp-3049	148	11	with	with	SCONJ
fnp-3049	148	12	the	the	DET
fnp-3049	148	13	grid	grid	NOUN
fnp-3049	148	14	set	set	VERB
fnp-3049	148	15	to	to	ADP
fnp-3049	148	16	200x200	200x200	NUM
fnp-3049	148	17	and	and	CCONJ
fnp-3049	148	18	the	the	DET
fnp-3049	148	19	frame	frame	NOUN
fnp-3049	148	20	set	set	VERB
fnp-3049	148	21	to	to	ADP
fnp-3049	148	22	40x40	40x40	NUM
fnp-3049	148	23	.	.	PUNCT
fnp-3049	149	1	the	the	DET
fnp-3049	149	2	dissector	dissector	NOUN
fnp-3049	149	3	height	height	NOUN
fnp-3049	149	4	used	use	VERB
fnp-3049	149	5	was	be	AUX
fnp-3049	149	6	10	10	NUM
fnp-3049	149	7	μm	μm	NOUN
fnp-3049	149	8	,	,	PUNCT
fnp-3049	149	9	with	with	ADP
fnp-3049	149	10	a	a	DET
fnp-3049	149	11	3	3	NUM
fnp-3049	149	12	μm	μm	NOUN
fnp-3049	149	13	guard	guard	NOUN
fnp-3049	149	14	zone	zone	NOUN
fnp-3049	149	15	.	.	PUNCT
fnp-3049	150	1	the	the	DET
fnp-3049	150	2	gunderson	gunderson	PROPN
fnp-3049	150	3	estimated	estimate	VERB
fnp-3049	150	4	m=1	m=1	PUNCT
fnp-3049	150	5	error	error	NOUN
fnp-3049	150	6	was	be	AUX
fnp-3049	150	7	less	less	ADJ
fnp-3049	150	8	than	than	ADP
fnp-3049	150	9	0.1	0.1	NUM
fnp-3049	150	10	and	and	CCONJ
fnp-3049	150	11	a	a	DET
fnp-3049	150	12	total	total	NOUN
fnp-3049	150	13	of	of	ADP
fnp-3049	150	14	nine	nine	NUM
fnp-3049	150	15	to	to	PART
fnp-3049	150	16	ten	ten	NUM
fnp-3049	150	17	animals	animal	NOUN
fnp-3049	150	18	per	per	ADP
fnp-3049	150	19	group	group	NOUN
fnp-3049	150	20	were	be	AUX
fnp-3049	150	21	counted	count	VERB
fnp-3049	150	22	.	.	PUNCT
fnp-3049	151	1	assessment	assessment	NOUN
fnp-3049	151	2	of	of	ADP
fnp-3049	151	3	microglia	microglia	ADJ
fnp-3049	151	4	morphology	morphology	NOUN
fnp-3049	151	5	microglia	microglia	ADJ
fnp-3049	151	6	hydraulic	hydraulic	ADJ
fnp-3049	151	7	radius	radius	NOUN
fnp-3049	151	8	(	(	PUNCT
fnp-3049	151	9	area	area	NOUN
fnp-3049	151	10	/	/	SYM
fnp-3049	151	11	perimeter	perimeter	NOUN
fnp-3049	151	12	ratio	ratio	NOUN
fnp-3049	151	13	)	)	PUNCT
fnp-3049	151	14	was	be	AUX
fnp-3049	151	15	investigated	investigate	VERB
fnp-3049	151	16	as	as	ADP
fnp-3049	151	17	previously	previously	ADV
fnp-3049	151	18	described13	described13	VERB
fnp-3049	151	19	.	.	PUNCT
fnp-3049	152	1	in	in	ADP
fnp-3049	152	2	short	short	ADJ
fnp-3049	152	3	,	,	PUNCT
fnp-3049	152	4	color	color	NOUN
fnp-3049	152	5	(	(	PUNCT
fnp-3049	152	6	rbg	rbg	NOUN
fnp-3049	152	7	)	)	PUNCT
fnp-3049	152	8	images	image	NOUN
fnp-3049	152	9	were	be	AUX
fnp-3049	152	10	generated	generate	VERB
fnp-3049	152	11	using	use	VERB
fnp-3049	152	12	a	a	DET
fnp-3049	152	13	60x	60x	NUM
fnp-3049	152	14	oil	oil	NOUN
fnp-3049	152	15	objective	objective	NOUN
fnp-3049	152	16	.	.	PUNCT
fnp-3049	153	1	following	follow	VERB
fnp-3049	153	2	imaging	imaging	PROPN
fnp-3049	153	3	,	,	PUNCT
fnp-3049	153	4	a	a	DET
fnp-3049	153	5	custom	custom	NOUN
fnp-3049	153	6	matlab	matlab	PROPN
fnp-3049	153	7	script	script	NOUN
fnp-3049	153	8	assessed	assess	VERB
fnp-3049	153	9	the	the	DET
fnp-3049	153	10	morphology	morphology	NOUN
fnp-3049	153	11	of	of	ADP
fnp-3049	153	12	the	the	DET
fnp-3049	153	13	imaged	imaged	ADJ
fnp-3049	153	14	microglia	microglia	NOUN
fnp-3049	153	15	,	,	PUNCT
fnp-3049	153	16	calculating	calculate	VERB
fnp-3049	153	17	the	the	DET
fnp-3049	153	18	area	area	NOUN
fnp-3049	153	19	/	/	SYM
fnp-3049	153	20	perimeter	perimeter	NOUN
fnp-3049	153	21	ratio	ratio	NOUN
fnp-3049	153	22	.	.	PUNCT
fnp-3049	154	1	for	for	ADP
fnp-3049	154	2	the	the	DET
fnp-3049	154	3	pff	pff	PROPN
fnp-3049	154	4	seeding	seeding	NOUN
fnp-3049	154	5	model	model	NOUN
fnp-3049	154	6	,	,	PUNCT
fnp-3049	154	7	five	five	NUM
fnp-3049	154	8	to	to	PART
fnp-3049	154	9	six	six	NUM
fnp-3049	154	10	animals	animal	NOUN
fnp-3049	154	11	per	per	ADP
fnp-3049	154	12	group	group	NOUN
fnp-3049	154	13	were	be	AUX
fnp-3049	154	14	analyzed	analyze	VERB
fnp-3049	154	15	.	.	PUNCT
fnp-3049	155	1	microglia	microglia	NOUN
fnp-3049	155	2	were	be	AUX
fnp-3049	155	3	imaged	image	VERB
fnp-3049	155	4	from	from	ADP
fnp-3049	155	5	every	every	DET
fnp-3049	155	6	6th	6th	ADJ
fnp-3049	155	7	aon	aon	PROPN
fnp-3049	155	8	section	section	NOUN
fnp-3049	155	9	and	and	CCONJ
fnp-3049	155	10	a	a	DET
fnp-3049	155	11	minimum	minimum	NOUN
fnp-3049	155	12	of	of	ADP
fnp-3049	155	13	30	30	NUM
fnp-3049	155	14	individual	individual	ADJ
fnp-3049	155	15	microglia	microglia	NOUN
fnp-3049	155	16	was	be	AUX
fnp-3049	155	17	analyzed	analyze	VERB
fnp-3049	155	18	per	per	ADP
fnp-3049	155	19	animal	animal	NOUN
fnp-3049	155	20	,	,	PUNCT
fnp-3049	155	21	with	with	ADP
fnp-3049	155	22	the	the	DET
fnp-3049	155	23	average	average	ADJ
fnp-3049	155	24	microglia	microglia	ADJ
fnp-3049	155	25	area	area	NOUN
fnp-3049	155	26	/	/	SYM
fnp-3049	155	27	perimeter	perimeter	NOUN
fnp-3049	155	28	ratio	ratio	NOUN
fnp-3049	155	29	reported	report	VERB
fnp-3049	155	30	.	.	PUNCT
fnp-3049	156	1	quantification	quantification	NOUN
fnp-3049	156	2	of	of	ADP
fnp-3049	156	3	fluorescent	fluorescent	NOUN
fnp-3049	156	4	lamp2	lamp2	NOUN
fnp-3049	156	5	signal	signal	VERB
fnp-3049	156	6	images	image	NOUN
fnp-3049	156	7	corresponding	correspond	VERB
fnp-3049	156	8	to	to	ADP
fnp-3049	156	9	the	the	DET
fnp-3049	156	10	aon	aon	PROPN
fnp-3049	156	11	were	be	AUX
fnp-3049	156	12	captured	capture	VERB
fnp-3049	156	13	using	use	VERB
fnp-3049	156	14	a	a	DET
fnp-3049	156	15	20x	20x	NOUN
fnp-3049	156	16	oil	oil	NOUN
fnp-3049	156	17	objective	objective	NOUN
fnp-3049	156	18	on	on	ADP
fnp-3049	156	19	a	a	DET
fnp-3049	156	20	nikon	nikon	PROPN
fnp-3049	156	21	a1plus	a1plus	ADJ
fnp-3049	156	22	-	-	PUNCT
fnp-3049	156	23	rsi	rsi	NOUN
fnp-3049	156	24	laser	laser	NOUN
fnp-3049	156	25	scanning	scan	VERB
fnp-3049	156	26	confocal	confocal	ADJ
fnp-3049	156	27	microscope	microscope	NOUN
fnp-3049	156	28	(	(	PUNCT
fnp-3049	156	29	nikon	nikon	PROPN
fnp-3049	156	30	)	)	PUNCT
fnp-3049	156	31	in	in	ADP
fnp-3049	156	32	a	a	DET
fnp-3049	156	33	blinded	blind	VERB
fnp-3049	156	34	manner	manner	NOUN
fnp-3049	156	35	.	.	PUNCT
fnp-3049	157	1	the	the	DET
fnp-3049	157	2	area	area	NOUN
fnp-3049	157	3	percentage	percentage	NOUN
fnp-3049	157	4	occupied	occupy	VERB
fnp-3049	157	5	by	by	ADP
fnp-3049	157	6	lamp2	lamp2	NOUN
fnp-3049	157	7	positive	positive	ADJ
fnp-3049	157	8	signal	signal	NOUN
fnp-3049	157	9	was	be	AUX
fnp-3049	157	10	quantified	quantify	VERB
fnp-3049	157	11	using	use	VERB
fnp-3049	157	12	fiji	fiji	PROPN
fnp-3049	157	13	software	software	NOUN
fnp-3049	157	14	(	(	PUNCT
fnp-3049	157	15	nation	nation	NOUN
fnp-3049	157	16	institute	institute	PROPN
fnp-3049	157	17	of	of	ADP
fnp-3049	157	18	health	health	NOUN
fnp-3049	157	19	)	)	PUNCT
fnp-3049	157	20	after	after	SCONJ
fnp-3049	157	21	an	an	DET
fnp-3049	157	22	unbiased	unbiased	ADJ
fnp-3049	157	23	threshold	threshold	NOUN
fnp-3049	157	24	was	be	AUX
fnp-3049	157	25	applied	apply	VERB
fnp-3049	157	26	.	.	PUNCT
fnp-3049	158	1	the	the	DET
fnp-3049	158	2	average	average	ADJ
fnp-3049	158	3	area	area	NOUN
fnp-3049	158	4	percentage	percentage	NOUN
fnp-3049	158	5	calculated	calculate	VERB
fnp-3049	158	6	for	for	ADP
fnp-3049	158	7	each	each	DET
fnp-3049	158	8	animal	animal	NOUN
fnp-3049	158	9	is	be	AUX
fnp-3049	158	10	reported	report	VERB
fnp-3049	158	11	here	here	ADV
fnp-3049	158	12	.	.	PUNCT
fnp-3049	159	1	for	for	ADP
fnp-3049	159	2	the	the	DET
fnp-3049	159	3	pff	pff	PROPN
fnp-3049	159	4	seeding	seeding	NOUN
fnp-3049	159	5	model	model	NOUN
fnp-3049	159	6	,	,	PUNCT
fnp-3049	159	7	a	a	DET
fnp-3049	159	8	total	total	NOUN
fnp-3049	159	9	of	of	ADP
fnp-3049	159	10	six	six	NUM
fnp-3049	159	11	mice	mouse	NOUN
fnp-3049	159	12	per	per	ADP
fnp-3049	159	13	group	group	NOUN
fnp-3049	159	14	were	be	AUX
fnp-3049	159	15	analyzed	analyze	VERB
fnp-3049	159	16	.	.	PUNCT
fnp-3049	160	1	statistics	statistic	NOUN
fnp-3049	160	2	all	all	DET
fnp-3049	160	3	aav	aav	PROPN
fnp-3049	160	4	and	and	CCONJ
fnp-3049	160	5	pff	pff	PROPN
fnp-3049	160	6	mouse	mouse	PROPN
fnp-3049	160	7	model	model	NOUN
fnp-3049	160	8	data	datum	NOUN
fnp-3049	160	9	were	be	AUX
fnp-3049	160	10	analyzed	analyze	VERB
fnp-3049	160	11	using	use	VERB
fnp-3049	160	12	r	r	NOUN
fnp-3049	160	13	v3.6.0	v3.6.0	NOUN
fnp-3049	160	14	(	(	PUNCT
fnp-3049	160	15	https://cran.r-project.org/	https://cran.r-project.org/	NOUN
fnp-3049	160	16	)	)	PUNCT
fnp-3049	160	17	and	and	CCONJ
fnp-3049	160	18	assumed	assume	VERB
fnp-3049	160	19	two	two	NUM
fnp-3049	160	20	-	-	PUNCT
fnp-3049	160	21	sided	sided	ADJ
fnp-3049	160	22	hypothesis	hypothesis	NOUN
fnp-3049	160	23	tests	test	VERB
fnp-3049	160	24	with	with	ADP
fnp-3049	160	25	a	a	DET
fnp-3049	160	26	significance	significance	NOUN
fnp-3049	160	27	level	level	NOUN
fnp-3049	160	28	<	<	NOUN
fnp-3049	160	29	0.05	0.05	NUM
fnp-3049	160	30	after	after	ADP
fnp-3049	160	31	benjamini	benjamini	ADJ
fnp-3049	160	32	-	-	PUNCT
fnp-3049	160	33	hochberg	hochberg	ADJ
fnp-3049	160	34	multiple	multiple	ADJ
fnp-3049	160	35	testing	testing	NOUN
fnp-3049	160	36	corrections	correction	NOUN
fnp-3049	160	37	.	.	PUNCT
fnp-3049	161	1	in	in	ADP
fnp-3049	161	2	the	the	DET
fnp-3049	161	3	pff	pff	PROPN
fnp-3049	161	4	model	model	NOUN
fnp-3049	161	5	,	,	PUNCT
fnp-3049	161	6	neuronal	neuronal	ADJ
fnp-3049	161	7	cell	cell	NOUN
fnp-3049	161	8	count	count	NOUN
fnp-3049	161	9	,	,	PUNCT
fnp-3049	161	10	iba1	iba1	PROPN
fnp-3049	161	11	and	and	CCONJ
fnp-3049	161	12	pser129	pser129	PROPN
fnp-3049	161	13	quantification	quantification	NOUN
fnp-3049	161	14	were	be	AUX
fnp-3049	161	15	done	do	VERB
fnp-3049	161	16	in	in	ADP
fnp-3049	161	17	parallel	parallel	NOUN
fnp-3049	161	18	with	with	ADP
fnp-3049	161	19	another	another	DET
fnp-3049	161	20	treatment	treatment	NOUN
fnp-3049	161	21	group	group	NOUN
fnp-3049	161	22	(	(	PUNCT
fnp-3049	161	23	pt302	pt302	PROPN
fnp-3049	161	24	,	,	PUNCT
fnp-3049	161	25	data	datum	NOUN
fnp-3049	161	26	not	not	PART
fnp-3049	161	27	shown	show	VERB
fnp-3049	161	28	)	)	PUNCT
fnp-3049	161	29	,	,	PUNCT
fnp-3049	161	30	meaning	mean	VERB
fnp-3049	161	31	they	they	PRON
fnp-3049	161	32	share	share	VERB
fnp-3049	161	33	the	the	DET
fnp-3049	161	34	same	same	ADJ
fnp-3049	161	35	set	set	NOUN
fnp-3049	161	36	of	of	ADP
fnp-3049	161	37	placebo	placebo	NOUN
fnp-3049	161	38	treated	treat	VERB
fnp-3049	161	39	animals	animal	NOUN
fnp-3049	161	40	;	;	PUNCT
fnp-3049	161	41	the	the	DET
fnp-3049	161	42	multiple	multiple	ADJ
fnp-3049	161	43	testing	testing	NOUN
fnp-3049	161	44	corrections	correction	NOUN
fnp-3049	161	45	take	take	VERB
fnp-3049	161	46	into	into	ADP
fnp-3049	161	47	account	account	NOUN
fnp-3049	161	48	these	these	DET
fnp-3049	161	49	additional	additional	ADJ
fnp-3049	161	50	comparisons	comparison	NOUN
fnp-3049	161	51	.	.	PUNCT
fnp-3049	162	1	for	for	ADP
fnp-3049	162	2	experiments	experiment	NOUN
fnp-3049	162	3	that	that	PRON
fnp-3049	162	4	analyzed	analyze	VERB
fnp-3049	162	5	both	both	DET
fnp-3049	162	6	hemispheres	hemisphere	NOUN
fnp-3049	162	7	of	of	ADP
fnp-3049	162	8	the	the	DET
fnp-3049	162	9	brain	brain	NOUN
fnp-3049	162	10	independently	independently	ADV
fnp-3049	162	11	(	(	PUNCT
fnp-3049	162	12	e.g.	e.g.	ADV
fnp-3049	162	13	ipsilateral	ipsilateral	ADJ
fnp-3049	162	14	versus	versus	X
fnp-3049	162	15	contralateral	contralateral	ADJ
fnp-3049	162	16	)	)	PUNCT
fnp-3049	162	17	the	the	DET
fnp-3049	162	18	appropriate	appropriate	ADJ
fnp-3049	162	19	mixed	mix	VERB
fnp-3049	162	20	-	-	PUNCT
fnp-3049	162	21	effects	effect	NOUN
fnp-3049	162	22	model	model	NOUN
fnp-3049	162	23	was	be	AUX
fnp-3049	162	24	used	use	VERB
fnp-3049	162	25	(	(	PUNCT
fnp-3049	162	26	r	r	NOUN
fnp-3049	162	27	package	package	NOUN
fnp-3049	162	28	lme4	lme4	PROPN
fnp-3049	162	29	https://cran.r-project.org/web/packages/lme4/index.html	https://cran.r-project.org/web/packages/lme4/index.html	PROPN
fnp-3049	162	30	unless	unless	SCONJ
fnp-3049	162	31	otherwise	otherwise	ADV
fnp-3049	162	32	noted	note	VERB
fnp-3049	162	33	)	)	PUNCT
fnp-3049	162	34	.	.	PUNCT
fnp-3049	163	1	count	count	PROPN
fnp-3049	163	2	data	datum	NOUN
fnp-3049	163	3	were	be	AUX
fnp-3049	163	4	analyzed	analyze	VERB
fnp-3049	163	5	using	use	VERB
fnp-3049	163	6	negative	negative	ADJ
fnp-3049	163	7	binomial	binomial	ADJ
fnp-3049	163	8	regressions	regression	NOUN
fnp-3049	163	9	;	;	PUNCT
fnp-3049	163	10	mixed	mixed	ADJ
fnp-3049	163	11	-	-	PUNCT
fnp-3049	163	12	effects	effect	NOUN
fnp-3049	163	13	negative	negative	ADJ
fnp-3049	163	14	binomial	binomial	ADJ
fnp-3049	163	15	regressions	regression	NOUN
fnp-3049	163	16	were	be	AUX
fnp-3049	163	17	done	do	VERB
fnp-3049	163	18	using	use	VERB
fnp-3049	163	19	the	the	DET
fnp-3049	163	20	r	r	NOUN
fnp-3049	163	21	package	package	NOUN
fnp-3049	163	22	glmmtmb	glmmtmb	NOUN
fnp-3049	163	23	and	and	CCONJ
fnp-3049	163	24	the	the	DET
fnp-3049	163	25	‘	'	PUNCT
fnp-3049	163	26	nbinom1	nbinom1	NOUN
fnp-3049	163	27	’	'	PUNCT
fnp-3049	163	28	family	family	NOUN
fnp-3049	163	29	(	(	PUNCT
fnp-3049	163	30	https://cran.r-project.org/web/packages/glmmtmb/index.html	https://cran.r-project.org/web/packages/glmmtmb/index.html	PROPN
fnp-3049	163	31	)	)	PUNCT
fnp-3049	163	32	.	.	PUNCT
fnp-3049	164	1	time	time	NOUN
fnp-3049	164	2	-	-	PUNCT
fnp-3049	164	3	to	to	ADP
fnp-3049	164	4	-	-	PUNCT
fnp-3049	164	5	event	event	NOUN
fnp-3049	164	6	data	datum	NOUN
fnp-3049	164	7	(	(	PUNCT
fnp-3049	164	8	e.g.	e.g.	ADV
fnp-3049	164	9	the	the	DET
fnp-3049	164	10	buried	bury	VERB
fnp-3049	164	11	pellet	pellet	NOUN
fnp-3049	164	12	test	test	NOUN
fnp-3049	164	13	)	)	PUNCT
fnp-3049	164	14	were	be	AUX
fnp-3049	164	15	analyzed	analyze	VERB
fnp-3049	164	16	using	use	VERB
fnp-3049	164	17	cox	cox	PROPN
fnp-3049	164	18	proportional	proportional	PROPN
fnp-3049	164	19	hazards	hazard	NOUN
fnp-3049	164	20	regression	regression	NOUN
fnp-3049	164	21	.	.	PUNCT
fnp-3049	165	1	all	all	DET
fnp-3049	165	2	other	other	ADJ
fnp-3049	165	3	data	datum	NOUN
fnp-3049	165	4	types	type	NOUN
fnp-3049	165	5	were	be	AUX
fnp-3049	165	6	analyzed	analyze	VERB
fnp-3049	165	7	via	via	ADP
fnp-3049	165	8	linear	linear	PROPN
fnp-3049	165	9	regression	regression	NOUN
fnp-3049	165	10	with	with	ADP
fnp-3049	165	11	log	log	NOUN
fnp-3049	165	12	and	and	CCONJ
fnp-3049	165	13	square	square	ADJ
fnp-3049	165	14	-	-	PUNCT
fnp-3049	165	15	root	root	NOUN
fnp-3049	165	16	transformed	transform	VERB
fnp-3049	165	17	outcomes	outcome	NOUN
fnp-3049	165	18	as	as	SCONJ
fnp-3049	165	19	needed	need	VERB
fnp-3049	165	20	based	base	VERB
fnp-3049	165	21	on	on	ADP
fnp-3049	165	22	standard	standard	ADJ
fnp-3049	165	23	regression	regression	NOUN
fnp-3049	165	24	diagnostics	diagnostic	NOUN
fnp-3049	165	25	(	(	PUNCT
fnp-3049	165	26	i.e.	i.e.	X
fnp-3049	165	27	normality	normality	NOUN
fnp-3049	165	28	of	of	ADP
fnp-3049	165	29	residuals	residual	NOUN
fnp-3049	165	30	and	and	CCONJ
fnp-3049	165	31	homoscedasticity	homoscedasticity	NOUN
fnp-3049	165	32	)	)	PUNCT
fnp-3049	165	33	(	(	PUNCT
fnp-3049	165	34	log	log	NOUN
fnp-3049	165	35	:	:	PUNCT
fnp-3049	165	36	if	if	SCONJ
fnp-3049	165	37	αsyn	αsyn	PROPN
fnp-3049	165	38	pser129	pser129	PROPN
fnp-3049	165	39	and	and	CCONJ
fnp-3049	165	40	soluble	soluble	ADJ
fnp-3049	165	41	αsyn	αsyn	NOUN
fnp-3049	165	42	;	;	PUNCT
fnp-3049	165	43	square	square	ADJ
fnp-3049	165	44	-	-	PUNCT
fnp-3049	165	45	root	root	NOUN
fnp-3049	165	46	:	:	PUNCT
fnp-3049	165	47	soluble	soluble	ADJ
fnp-3049	165	48	αsyn	αsyn	NOUN
fnp-3049	165	49	pser129	pser129	PROPN
fnp-3049	165	50	,	,	PUNCT
fnp-3049	165	51	insoluble	insoluble	ADJ
fnp-3049	165	52	human	human	ADJ
fnp-3049	165	53	αsyn	αsyn	NOUN
fnp-3049	165	54	,	,	PUNCT
fnp-3049	165	55	insoluble	insoluble	ADJ
fnp-3049	165	56	αsyn	αsyn	NOUN
fnp-3049	165	57	pser129	pser129	PROPN
fnp-3049	165	58	)	)	PUNCT
fnp-3049	165	59	.	.	PUNCT
fnp-3049	166	1	cook	cook	PROPN
fnp-3049	166	2	’s	’s	PART
fnp-3049	166	3	distance	distance	NOUN
fnp-3049	166	4	was	be	AUX
fnp-3049	166	5	used	use	VERB
fnp-3049	166	6	to	to	PART
fnp-3049	166	7	assess	assess	VERB
fnp-3049	166	8	individual	individual	ADJ
fnp-3049	166	9	observations	observation	NOUN
fnp-3049	166	10	with	with	ADP
fnp-3049	166	11	high	high	ADJ
fnp-3049	166	12	amounts	amount	NOUN
fnp-3049	166	13	of	of	ADP
fnp-3049	166	14	leverage	leverage	NOUN
fnp-3049	166	15	(	(	PUNCT
fnp-3049	166	16	set	set	VERB
fnp-3049	166	17	as	as	ADP
fnp-3049	166	18	4/(n	4/(n	NOUN
fnp-3049	166	19	-	-	NOUN
fnp-3049	166	20	p-1	p-1	NOUN
fnp-3049	166	21	)	)	PUNCT
fnp-3049	166	22	)	)	PUNCT
fnp-3049	166	23	.	.	PUNCT
fnp-3049	167	1	for	for	ADP
fnp-3049	167	2	linear	linear	PROPN
fnp-3049	167	3	regressions	regression	NOUN
fnp-3049	167	4	with	with	ADP
fnp-3049	167	5	highly	highly	ADV
fnp-3049	167	6	influential	influential	ADJ
fnp-3049	167	7	observations	observation	NOUN
fnp-3049	167	8	,	,	PUNCT
fnp-3049	167	9	robust	robust	ADJ
fnp-3049	167	10	regressions	regression	NOUN
fnp-3049	167	11	with	with	ADP
fnp-3049	167	12	mm	mm	NOUN
fnp-3049	167	13	estimation	estimation	NOUN
fnp-3049	167	14	were	be	AUX
fnp-3049	167	15	used	use	VERB
fnp-3049	167	16	.	.	PUNCT
fnp-3049	168	1	zero	zero	NUM
fnp-3049	168	2	variance	variance	NOUN
fnp-3049	168	3	data	datum	NOUN
fnp-3049	168	4	(	(	PUNCT
fnp-3049	168	5	i.e.	i.e.	X
fnp-3049	168	6	dab	dab	NOUN
fnp-3049	168	7	αsyn	αsyn	NOUN
fnp-3049	168	8	pser129	pser129	PROPN
fnp-3049	168	9	+	+	PROPN
fnp-3049	168	10	,	,	PUNCT
fnp-3049	168	11	if	if	SCONJ
fnp-3049	168	12	αsyn	αsyn	PRON
fnp-3049	168	13	pser129	pser129	PROPN
fnp-3049	168	14	+	+	ADJ
fnp-3049	168	15	,	,	PUNCT
fnp-3049	168	16	soluble	soluble	ADJ
fnp-3049	168	17	human	human	ADJ
fnp-3049	168	18	αsyn	αsyn	NOUN
fnp-3049	168	19	,	,	PUNCT
fnp-3049	168	20	and	and	CCONJ
fnp-3049	168	21	nissl+	nissl+	PRON
fnp-3049	168	22	measures	measure	NOUN
fnp-3049	168	23	across	across	ADP
fnp-3049	168	24	both	both	CCONJ
fnp-3049	168	25	naive	naive	ADJ
fnp-3049	168	26	and	and	CCONJ
fnp-3049	168	27	gfp	gfp	PROPN
fnp-3049	168	28	injected	inject	VERB
fnp-3049	168	29	animals	animal	NOUN
fnp-3049	168	30	)	)	PUNCT
fnp-3049	168	31	,	,	PUNCT
fnp-3049	168	32	logistic	logistic	ADJ
fnp-3049	168	33	regression	regression	NOUN
fnp-3049	168	34	with	with	ADP
fnp-3049	168	35	a	a	DET
fnp-3049	168	36	firth	firth	PROPN
fnp-3049	168	37	correction	correction	NOUN
fnp-3049	168	38	was	be	AUX
fnp-3049	168	39	used	use	VERB
fnp-3049	168	40	to	to	PART
fnp-3049	168	41	determine	determine	VERB
fnp-3049	168	42	if	if	SCONJ
fnp-3049	168	43	the	the	DET
fnp-3049	168	44	odds	odd	NOUN
fnp-3049	168	45	of	of	ADP
fnp-3049	168	46	detection	detection	NOUN
fnp-3049	168	47	versus	versus	ADP
fnp-3049	168	48	no	no	DET
fnp-3049	168	49	detection	detection	NOUN
fnp-3049	168	50	differed	differ	VERB
fnp-3049	168	51	between	between	ADP
fnp-3049	168	52	groups	group	NOUN
fnp-3049	168	53	.	.	PUNCT
fnp-3049	169	1	an	an	DET
fnp-3049	169	2	equivalence	equivalence	NOUN
fnp-3049	169	3	interval	interval	NOUN
fnp-3049	169	4	of	of	ADP
fnp-3049	169	5	+	+	NOUN
fnp-3049	169	6	/-10	/-10	SYM
fnp-3049	169	7	%	%	NOUN
fnp-3049	169	8	was	be	AUX
fnp-3049	169	9	used	use	VERB
fnp-3049	169	10	to	to	PART
fnp-3049	169	11	determine	determine	VERB
fnp-3049	169	12	if	if	SCONJ
fnp-3049	169	13	groups	group	NOUN
fnp-3049	169	14	had	have	VERB
fnp-3049	169	15	strong	strong	ADJ
fnp-3049	169	16	evidence	evidence	NOUN
fnp-3049	169	17	for	for	ADP
fnp-3049	169	18	equivalence	equivalence	NOUN
fnp-3049	169	19	based	base	VERB
fnp-3049	169	20	on	on	ADP
fnp-3049	169	21	their	their	PRON
fnp-3049	169	22	95	95	NUM
fnp-3049	169	23	%	%	NOUN
fnp-3049	169	24	confidence	confidence	NOUN
fnp-3049	169	25	intervals	interval	NOUN
fnp-3049	169	26	.	.	PUNCT
fnp-3049	170	1	results	result	NOUN
fnp-3049	170	2	inhibiting	inhibit	VERB
fnp-3049	170	3	the	the	DET
fnp-3049	170	4	mpc	mpc	NOUN
fnp-3049	170	5	in	in	ADP
fnp-3049	170	6	a	a	DET
fnp-3049	170	7	viral	viral	ADJ
fnp-3049	170	8	vector	vector	NOUN
fnp-3049	170	9	-	-	PUNCT
fnp-3049	170	10	based	base	VERB
fnp-3049	170	11	model	model	NOUN
fnp-3049	170	12	of	of	ADP
fnp-3049	170	13	human	human	PROPN
fnp-3049	170	14	α	α	PROPN
fnp-3049	170	15	-	-	PUNCT
fnp-3049	170	16	syn	syn	NOUN
fnp-3049	170	17	overexpression	overexpression	NOUN
fnp-3049	170	18	to	to	PART
fnp-3049	170	19	determine	determine	VERB
fnp-3049	170	20	the	the	DET
fnp-3049	170	21	effects	effect	NOUN
fnp-3049	170	22	of	of	ADP
fnp-3049	170	23	inhibiting	inhibit	VERB
fnp-3049	170	24	the	the	DET
fnp-3049	170	25	mpc	mpc	NOUN
fnp-3049	170	26	on	on	ADP
fnp-3049	170	27	αsyn	αsyn	PROPN
fnp-3049	170	28	aggregation	aggregation	NOUN
fnp-3049	170	29	,	,	PUNCT
fnp-3049	170	30	we	we	PRON
fnp-3049	170	31	used	use	VERB
fnp-3049	170	32	a	a	DET
fnp-3049	170	33	slowly	slowly	ADV
fnp-3049	170	34	progressing	progress	VERB
fnp-3049	170	35	viral	viral	ADJ
fnp-3049	170	36	vector	vector	NOUN
fnp-3049	170	37	-	-	PUNCT
fnp-3049	170	38	based	base	VERB
fnp-3049	170	39	model	model	NOUN
fnp-3049	170	40	that	that	PRON
fnp-3049	170	41	overexpresses	overexpresse	VERB
fnp-3049	170	42	αsyn	αsyn	NOUN
fnp-3049	170	43	.	.	PUNCT
fnp-3049	171	1	we	we	PRON
fnp-3049	171	2	selected	select	VERB
fnp-3049	171	3	two	two	NUM
fnp-3049	171	4	doses	dose	NOUN
fnp-3049	171	5	of	of	ADP
fnp-3049	171	6	viral	viral	ADJ
fnp-3049	171	7	vector	vector	NOUN
fnp-3049	171	8	,	,	PUNCT
fnp-3049	171	9	which	which	PRON
fnp-3049	171	10	from	from	ADP
fnp-3049	171	11	here	here	ADV
fnp-3049	171	12	on	on	ADV
fnp-3049	171	13	will	will	AUX
fnp-3049	171	14	be	be	AUX
fnp-3049	171	15	referred	refer	VERB
fnp-3049	171	16	to	to	ADP
fnp-3049	171	17	as	as	ADP
fnp-3049	171	18	‘	'	PUNCT
fnp-3049	171	19	αsyn	αsyn	ADJ
fnp-3049	171	20	low	low	ADJ
fnp-3049	171	21	’	'	PUNCT
fnp-3049	171	22	(	(	PUNCT
fnp-3049	171	23	4.3x1013gc	4.3x1013gc	NUM
fnp-3049	171	24	/	/	SYM
fnp-3049	171	25	ml	ml	NOUN
fnp-3049	171	26	)	)	PUNCT
fnp-3049	171	27	and	and	CCONJ
fnp-3049	171	28	‘	'	PUNCT
fnp-3049	171	29	αsyn	αsyn	ADJ
fnp-3049	171	30	high	high	ADJ
fnp-3049	171	31	’	'	PUNCT
fnp-3049	171	32	(	(	PUNCT
fnp-3049	171	33	8.6x1013gc	8.6x1013gc	VERB
fnp-3049	171	34	/	/	SYM
fnp-3049	171	35	ml	ml	NOUN
fnp-3049	171	36	)	)	PUNCT
fnp-3049	171	37	.	.	PUNCT
fnp-3049	172	1	these	these	DET
fnp-3049	172	2	two	two	NUM
fnp-3049	172	3	titers	titer	NOUN
fnp-3049	172	4	yield	yield	VERB
fnp-3049	172	5	a	a	DET
fnp-3049	172	6	4and	4and	NOUN
fnp-3049	172	7	6	6	NUM
fnp-3049	172	8	-	-	ADJ
fnp-3049	172	9	fold	fold	ADJ
fnp-3049	172	10	overexpression	overexpression	NOUN
fnp-3049	172	11	of	of	ADP
fnp-3049	172	12	αsyn	αsyn	NOUN
fnp-3049	172	13	in	in	ADP
fnp-3049	172	14	rat	rat	NOUN
fnp-3049	172	15	snpc	snpc	NOUN
fnp-3049	172	16	,	,	PUNCT
fnp-3049	172	17	respectively	respectively	ADV
fnp-3049	172	18	(	(	PUNCT
fnp-3049	172	19	fig	fig	NOUN
fnp-3049	172	20	.	.	PUNCT
fnp-3049	173	1	1a	1a	NOUN
fnp-3049	173	2	,	,	PUNCT
fnp-3049	173	3	3b	3b	NUM
fnp-3049	173	4	)	)	PUNCT
fnp-3049	173	5	.	.	PUNCT
fnp-3049	174	1	fig	fig	NOUN
fnp-3049	174	2	1	1	NUM
fnp-3049	174	3	.	.	PUNCT
fnp-3049	175	1	msdc-0160	msdc-0160	ADJ
fnp-3049	175	2	treatment	treatment	NOUN
fnp-3049	175	3	does	do	AUX
fnp-3049	175	4	not	not	PART
fnp-3049	175	5	influence	influence	VERB
fnp-3049	175	6	nigral	nigral	ADJ
fnp-3049	175	7	dopaminergic	dopaminergic	ADJ
fnp-3049	175	8	cell	cell	NOUN
fnp-3049	175	9	viability	viability	NOUN
fnp-3049	175	10	in	in	ADP
fnp-3049	175	11	a	a	DET
fnp-3049	175	12	progressive	progressive	ADJ
fnp-3049	175	13	αsyn	αsyn	ADJ
fnp-3049	175	14	overexpression	overexpression	NOUN
fnp-3049	175	15	model	model	NOUN
fnp-3049	175	16	.	.	PUNCT
fnp-3049	176	1	a	a	DET
fnp-3049	176	2	)	)	PUNCT
fnp-3049	176	3	experimental	experimental	ADJ
fnp-3049	176	4	overview	overview	NOUN
fnp-3049	176	5	of	of	ADP
fnp-3049	176	6	the	the	DET
fnp-3049	176	7	αsyn	αsyn	ADJ
fnp-3049	176	8	viral	viral	ADJ
fnp-3049	176	9	vector	vector	NOUN
fnp-3049	176	10	overexpression	overexpression	NOUN
fnp-3049	176	11	model	model	NOUN
fnp-3049	176	12	in	in	ADP
fnp-3049	176	13	rat	rat	PROPN
fnp-3049	176	14	sn	sn	PROPN
fnp-3049	176	15	.	.	PUNCT
fnp-3049	177	1	b	b	X
fnp-3049	177	2	)	)	PUNCT
fnp-3049	177	3	th	th	X
fnp-3049	177	4	expression	expression	NOUN
fnp-3049	177	5	and	and	CCONJ
fnp-3049	177	6	nissl+	nissl+	NOUN
fnp-3049	177	7	cells	cell	NOUN
fnp-3049	177	8	in	in	ADP
fnp-3049	177	9	rat	rat	PROPN
fnp-3049	177	10	sn	sn	PROPN
fnp-3049	177	11	for	for	ADP
fnp-3049	177	12	animals	animal	NOUN
fnp-3049	177	13	treated	treat	VERB
fnp-3049	177	14	with	with	ADP
fnp-3049	177	15	placebo	placebo	NOUN
fnp-3049	177	16	or	or	CCONJ
fnp-3049	177	17	msdc-0160	msdc-0160	NOUN
fnp-3049	177	18	in	in	ADP
fnp-3049	177	19	control	control	NOUN
fnp-3049	177	20	or	or	CCONJ
fnp-3049	177	21	experimental	experimental	ADJ
fnp-3049	177	22	conditions	condition	NOUN
fnp-3049	177	23	.	.	PUNCT
fnp-3049	178	1	scale	scale	NOUN
fnp-3049	178	2	bar	bar	NOUN
fnp-3049	178	3	=	=	PUNCT
fnp-3049	178	4	500	500	NUM
fnp-3049	178	5	μm	μm	NOUN
fnp-3049	178	6	.	.	PUNCT
fnp-3049	179	1	c	c	X
fnp-3049	179	2	)	)	PUNCT
fnp-3049	179	3	stereological	stereological	ADJ
fnp-3049	179	4	quantification	quantification	NOUN
fnp-3049	179	5	of	of	ADP
fnp-3049	179	6	total	total	ADJ
fnp-3049	179	7	dopamine	dopamine	NOUN
fnp-3049	179	8	neurons	neuron	NOUN
fnp-3049	179	9	in	in	ADP
fnp-3049	179	10	rat	rat	NOUN
fnp-3049	179	11	snpc	snpc	NOUN
fnp-3049	179	12	for	for	ADP
fnp-3049	179	13	ipsiand	ipsiand	NOUN
fnp-3049	179	14	contralateral	contralateral	ADJ
fnp-3049	179	15	sides	side	NOUN
fnp-3049	179	16	.	.	PUNCT
fnp-3049	180	1	the	the	DET
fnp-3049	180	2	contralateral	contralateral	ADJ
fnp-3049	180	3	hemisphere	hemisphere	ADV
fnp-3049	180	4	had	have	VERB
fnp-3049	180	5	significantly	significantly	ADV
fnp-3049	180	6	more	more	ADJ
fnp-3049	180	7	th	th	X
fnp-3049	180	8	cells	cell	NOUN
fnp-3049	180	9	than	than	ADP
fnp-3049	180	10	the	the	DET
fnp-3049	180	11	ipsilateral	ipsilateral	NOUN
fnp-3049	180	12	in	in	ADP
fnp-3049	180	13	the	the	DET
fnp-3049	180	14	αsyn	αsyn	ADJ
fnp-3049	180	15	high	high	ADJ
fnp-3049	180	16	mice	mouse	NOUN
fnp-3049	180	17	(	(	PUNCT
fnp-3049	180	18	p	p	NOUN
fnp-3049	180	19	=	=	NOUN
fnp-3049	180	20	0.001	0.001	NUM
fnp-3049	180	21	,	,	PUNCT
fnp-3049	180	22	~22.5	~22.5	ADP
fnp-3049	180	23	%	%	NOUN
fnp-3049	180	24	more	more	ADJ
fnp-3049	180	25	cells	cell	NOUN
fnp-3049	180	26	ci	ci	NOUN
fnp-3049	181	1	=	=	NOUN
fnp-3049	181	2	10.3	10.3	NUM
fnp-3049	181	3	%	%	NOUN
fnp-3049	181	4	36.0	36.0	NUM
fnp-3049	181	5	%	%	NOUN
fnp-3049	181	6	,	,	PUNCT
fnp-3049	181	7	negative	negative	ADJ
fnp-3049	181	8	binomial	binomial	ADJ
fnp-3049	181	9	mixed	mixed	ADJ
fnp-3049	181	10	-	-	PUNCT
fnp-3049	181	11	effect	effect	NOUN
fnp-3049	181	12	model	model	NOUN
fnp-3049	181	13	,	,	PUNCT
fnp-3049	181	14	n	n	NOUN
fnp-3049	181	15	=	=	SYM
fnp-3049	181	16	8	8	NUM
fnp-3049	181	17	,	,	PUNCT
fnp-3049	181	18	s.e.m	s.e.m	NOUN
fnp-3049	181	19	.	.	PUNCT
fnp-3049	181	20	)	)	PUNCT
fnp-3049	181	21	.	.	PUNCT
fnp-3049	182	1	in	in	ADP
fnp-3049	182	2	the	the	DET
fnp-3049	182	3	ipsilateral	ipsilateral	ADJ
fnp-3049	182	4	side	side	NOUN
fnp-3049	182	5	,	,	PUNCT
fnp-3049	182	6	αsyn	αsyn	PROPN
fnp-3049	182	7	high	high	ADV
fnp-3049	182	8	had	have	VERB
fnp-3049	182	9	significantly	significantly	ADV
fnp-3049	182	10	fewer	few	ADJ
fnp-3049	182	11	th	th	NOUN
fnp-3049	182	12	cells	cell	NOUN
fnp-3049	182	13	than	than	ADP
fnp-3049	182	14	naïve	naïve	ADJ
fnp-3049	182	15	,	,	PUNCT
fnp-3049	182	16	gfp	gfp	PROPN
fnp-3049	182	17	and	and	CCONJ
fnp-3049	182	18	αsyn	αsyn	PROPN
fnp-3049	182	19	low	low	ADJ
fnp-3049	182	20	(	(	PUNCT
fnp-3049	182	21	p	p	X
fnp-3049	182	22	=	=	NOUN
fnp-3049	182	23	0.031	0.031	NUM
fnp-3049	182	24	,	,	PUNCT
fnp-3049	182	25	14.9	14.9	NUM
fnp-3049	182	26	%	%	NOUN
fnp-3049	182	27	fewer	few	ADJ
fnp-3049	182	28	ci	ci	NOUN
fnp-3049	182	29	=	=	NUM
fnp-3049	182	30	4.8	4.8	NUM
fnp-3049	182	31	–	–	PUNCT
fnp-3049	182	32	23.9	23.9	NUM
fnp-3049	182	33	,	,	PUNCT
fnp-3049	182	34	*	*	PUNCT
fnp-3049	182	35	p	p	X
fnp-3049	182	36	=	=	NOUN
fnp-3049	182	37	0.05	0.05	NUM
fnp-3049	182	38	,	,	PUNCT
fnp-3049	182	39	13.4	13.4	NUM
fnp-3049	182	40	%	%	NOUN
fnp-3049	182	41	fewer	few	ADJ
fnp-3049	182	42	95	95	NUM
fnp-3049	182	43	%	%	NOUN
fnp-3049	182	44	ci	ci	NOUN
fnp-3049	182	45	3.1	3.1	NUM
fnp-3049	182	46	22.6	22.6	NUM
fnp-3049	182	47	and	and	CCONJ
fnp-3049	182	48	p	p	NOUN
fnp-3049	182	49	=	=	PROPN
fnp-3049	182	50	0.0313	0.0313	NUM
fnp-3049	182	51	,	,	PUNCT
fnp-3049	182	52	15.6	15.6	NUM
fnp-3049	182	53	%	%	NOUN
fnp-3049	182	54	fewer	few	ADJ
fnp-3049	182	55	ci	ci	NOUN
fnp-3049	182	56	=	=	SYM
fnp-3049	182	57	24.55.6	24.55.6	NUM
fnp-3049	182	58	,	,	PUNCT
fnp-3049	182	59	respectively	respectively	ADV
fnp-3049	182	60	,	,	PUNCT
fnp-3049	182	61	negative	negative	ADJ
fnp-3049	182	62	binomial	binomial	ADJ
fnp-3049	182	63	mixed	mixed	ADJ
fnp-3049	182	64	-	-	PUNCT
fnp-3049	182	65	effect	effect	NOUN
fnp-3049	182	66	model	model	NOUN
fnp-3049	182	67	,	,	PUNCT
fnp-3049	182	68	n	n	NOUN
fnp-3049	182	69	=	=	SYM
fnp-3049	182	70	8	8	NUM
fnp-3049	182	71	,	,	PUNCT
fnp-3049	182	72	sem	sem	NOUN
fnp-3049	182	73	)	)	PUNCT
fnp-3049	182	74	.	.	PUNCT
fnp-3049	183	1	d	d	X
fnp-3049	183	2	)	)	PUNCT
fnp-3049	183	3	stereological	stereological	ADJ
fnp-3049	183	4	quantification	quantification	NOUN
fnp-3049	183	5	of	of	ADP
fnp-3049	183	6	nissl+	nissl+	NOUN
fnp-3049	183	7	cells	cell	NOUN
fnp-3049	183	8	in	in	ADP
fnp-3049	183	9	rat	rat	PROPN
fnp-3049	183	10	sn	sn	PROPN
fnp-3049	183	11	for	for	ADP
fnp-3049	183	12	ipsiand	ipsiand	NOUN
fnp-3049	183	13	contralateral	contralateral	ADJ
fnp-3049	183	14	sides	side	NOUN
fnp-3049	183	15	.	.	PUNCT
fnp-3049	184	1	for	for	ADP
fnp-3049	184	2	the	the	DET
fnp-3049	184	3	αsyn	αsyn	PROPN
fnp-3049	184	4	high	high	ADJ
fnp-3049	184	5	group	group	NOUN
fnp-3049	184	6	,	,	PUNCT
fnp-3049	184	7	the	the	DET
fnp-3049	184	8	ipsilateral	ipsilateral	ADJ
fnp-3049	184	9	side	side	NOUN
fnp-3049	184	10	has	have	VERB
fnp-3049	184	11	~	~	SYM
fnp-3049	184	12	13	13	NUM
fnp-3049	184	13	%	%	NOUN
fnp-3049	184	14	fewer	few	ADJ
fnp-3049	184	15	nissl+	nissl+	NOUN
fnp-3049	184	16	cells	cell	NOUN
fnp-3049	184	17	across	across	ADP
fnp-3049	184	18	both	both	DET
fnp-3049	184	19	treatment	treatment	NOUN
fnp-3049	184	20	groups	group	NOUN
fnp-3049	184	21	than	than	ADP
fnp-3049	184	22	the	the	DET
fnp-3049	184	23	contralateral	contralateral	ADJ
fnp-3049	184	24	(	(	PUNCT
fnp-3049	184	25	p	p	X
fnp-3049	184	26	<	<	X
fnp-3049	184	27	0.0001	0.0001	NUM
fnp-3049	184	28	,	,	PUNCT
fnp-3049	184	29	95	95	NUM
fnp-3049	184	30	%	%	NOUN
fnp-3049	184	31	ci	ci	NOUN
fnp-3049	184	32	6.4	6.4	NUM
fnp-3049	184	33	20.1	20.1	NUM
fnp-3049	184	34	,	,	PUNCT
fnp-3049	184	35	negative	negative	ADJ
fnp-3049	184	36	binomial	binomial	ADJ
fnp-3049	184	37	mixed	mixed	ADJ
fnp-3049	184	38	-	-	PUNCT
fnp-3049	184	39	effect	effect	NOUN
fnp-3049	184	40	model	model	NOUN
fnp-3049	184	41	,	,	PUNCT
fnp-3049	184	42	n	n	NOUN
fnp-3049	184	43	=	=	SYM
fnp-3049	184	44	8	8	NUM
fnp-3049	184	45	,	,	PUNCT
fnp-3049	184	46	sem	sem	NOUN
fnp-3049	184	47	)	)	PUNCT
fnp-3049	184	48	.	.	PUNCT
fnp-3049	185	1	αsyn	αsyn	PROPN
fnp-3049	185	2	high	high	PROPN
fnp-3049	185	3	shows	show	VERB
fnp-3049	185	4	significantly	significantly	ADV
fnp-3049	185	5	fewer	few	ADJ
fnp-3049	185	6	nissl+	nissl+	PART
fnp-3049	185	7	cells	cell	NOUN
fnp-3049	185	8	compared	compare	VERB
fnp-3049	185	9	to	to	ADP
fnp-3049	185	10	animals	animal	NOUN
fnp-3049	185	11	injected	inject	VERB
fnp-3049	185	12	with	with	ADP
fnp-3049	185	13	naive	naive	ADJ
fnp-3049	185	14	,	,	PUNCT
fnp-3049	185	15	gfp	gfp	PROPN
fnp-3049	185	16	,	,	PUNCT
fnp-3049	185	17	or	or	CCONJ
fnp-3049	185	18	low	low	ADJ
fnp-3049	185	19	amounts	amount	NOUN
fnp-3049	185	20	of	of	ADP
fnp-3049	185	21	αsyn	αsyn	NOUN
fnp-3049	185	22	(	(	PUNCT
fnp-3049	185	23	p	p	X
fnp-3049	185	24	<	<	X
fnp-3049	185	25	0.001	0.001	NUM
fnp-3049	185	26	for	for	ADP
fnp-3049	185	27	all	all	DET
fnp-3049	185	28	3	3	NUM
fnp-3049	185	29	,	,	PUNCT
fnp-3049	185	30	gfp	gfp	NOUN
fnp-3049	185	31	:	:	PUNCT
fnp-3049	185	32	15	15	NUM
fnp-3049	185	33	%	%	NOUN
fnp-3049	185	34	fewer	few	ADJ
fnp-3049	185	35	ci	ci	NOUN
fnp-3049	185	36	=	=	SYM
fnp-3049	185	37	8	8	NUM
fnp-3049	185	38	%	%	NOUN
fnp-3049	185	39	21	21	NUM
fnp-3049	185	40	%	%	NOUN
fnp-3049	185	41	,	,	PUNCT
fnp-3049	185	42	naive	naive	ADJ
fnp-3049	185	43	:	:	PUNCT
fnp-3049	185	44	18.4	18.4	NUM
fnp-3049	185	45	%	%	NOUN
fnp-3049	185	46	fewer	few	ADJ
fnp-3049	185	47	ci	ci	NOUN
fnp-3049	185	48	=	=	NUM
fnp-3049	185	49	12.0	12.0	NUM
fnp-3049	185	50	%	%	NOUN
fnp-3049	185	51	24.4	24.4	NUM
fnp-3049	185	52	%	%	NOUN
fnp-3049	185	53	,	,	PUNCT
fnp-3049	185	54	αsyn	αsyn	PROPN
fnp-3049	185	55	low	low	ADJ
fnp-3049	185	56	:	:	PUNCT
fnp-3049	185	57	16	16	NUM
fnp-3049	185	58	%	%	NOUN
fnp-3049	185	59	fewer	few	ADJ
fnp-3049	185	60	ci	ci	NOUN
fnp-3049	185	61	=	=	NUM
fnp-3049	185	62	22.2	22.2	NUM
fnp-3049	185	63	%	%	NOUN
fnp-3049	185	64	9.3	9.3	NUM
fnp-3049	185	65	%	%	NOUN
fnp-3049	185	66	,	,	PUNCT
fnp-3049	185	67	negative	negative	ADJ
fnp-3049	185	68	binomial	binomial	ADJ
fnp-3049	185	69	mixed	mixed	ADJ
fnp-3049	185	70	-	-	PUNCT
fnp-3049	185	71	effect	effect	NOUN
fnp-3049	185	72	model	model	NOUN
fnp-3049	185	73	,	,	PUNCT
fnp-3049	185	74	n	n	NOUN
fnp-3049	185	75	=	=	SYM
fnp-3049	185	76	8	8	NUM
fnp-3049	185	77	,	,	PUNCT
fnp-3049	185	78	sem	sem	NOUN
fnp-3049	185	79	)	)	PUNCT
fnp-3049	185	80	.	.	PUNCT
fnp-3049	186	1	female	female	ADJ
fnp-3049	186	2	rats	rat	NOUN
fnp-3049	186	3	were	be	AUX
fnp-3049	186	4	stereotactically	stereotactically	ADV
fnp-3049	186	5	injected	inject	VERB
fnp-3049	186	6	in	in	ADP
fnp-3049	186	7	snpc	snpc	NOUN
fnp-3049	186	8	at	at	ADP
fnp-3049	186	9	8	8	NUM
fnp-3049	186	10	weeks	week	NOUN
fnp-3049	186	11	of	of	ADP
fnp-3049	186	12	age	age	NOUN
fnp-3049	186	13	with	with	ADP
fnp-3049	186	14	raav2/5	raav2/5	PRON
fnp-3049	186	15	cmv	cmv	NOUN
fnp-3049	186	16	-	-	PUNCT
fnp-3049	186	17	syn	syn	NOUN
fnp-3049	186	18	-	-	PUNCT
fnp-3049	186	19	αsyn	αsyn	NOUN
fnp-3049	186	20	or	or	CCONJ
fnp-3049	186	21	raav2/5	raav2/5	PRON
fnp-3049	186	22	cmv	cmv	NOUN
fnp-3049	186	23	-	-	PUNCT
fnp-3049	186	24	syn	syn	NOUN
fnp-3049	186	25	-	-	PUNCT
fnp-3049	186	26	gfp	gfp	PROPN
fnp-3049	186	27	expressing	express	VERB
fnp-3049	186	28	vector	vector	NOUN
fnp-3049	186	29	that	that	PRON
fnp-3049	186	30	served	serve	VERB
fnp-3049	186	31	as	as	ADP
fnp-3049	186	32	a	a	DET
fnp-3049	186	33	control	control	NOUN
fnp-3049	186	34	(	(	PUNCT
fnp-3049	186	35	fig	fig	NOUN
fnp-3049	186	36	.	.	PUNCT
fnp-3049	187	1	1a	1a	NOUN
fnp-3049	187	2	)	)	PUNCT
fnp-3049	187	3	.	.	PUNCT
fnp-3049	188	1	one	one	NUM
fnp-3049	188	2	week	week	NOUN
fnp-3049	188	3	post	post	ADJ
fnp-3049	188	4	-	-	ADJ
fnp-3049	188	5	surgery	surgery	NOUN
fnp-3049	188	6	,	,	PUNCT
fnp-3049	188	7	the	the	DET
fnp-3049	188	8	animals	animal	NOUN
fnp-3049	188	9	were	be	AUX
fnp-3049	188	10	allowed	allow	VERB
fnp-3049	188	11	free	free	ADJ
fnp-3049	188	12	access	access	NOUN
fnp-3049	188	13	to	to	ADP
fnp-3049	188	14	chow	chow	PROPN
fnp-3049	188	15	containing	contain	VERB
fnp-3049	188	16	either	either	CCONJ
fnp-3049	188	17	msdc-0160	msdc-0160	ADJ
fnp-3049	188	18	(	(	PUNCT
fnp-3049	188	19	30mg	30mg	NUM
fnp-3049	188	20	/	/	SYM
fnp-3049	188	21	kg	kg	NOUN
fnp-3049	188	22	)	)	PUNCT
fnp-3049	188	23	or	or	CCONJ
fnp-3049	188	24	placebo	placebo	NOUN
fnp-3049	188	25	for	for	ADP
fnp-3049	188	26	four	four	NUM
fnp-3049	188	27	months	month	NOUN
fnp-3049	188	28	.	.	PUNCT
fnp-3049	189	1	in	in	ADP
fnp-3049	189	2	order	order	NOUN
fnp-3049	189	3	to	to	PART
fnp-3049	189	4	evaluate	evaluate	VERB
fnp-3049	189	5	the	the	DET
fnp-3049	189	6	uptake	uptake	NOUN
fnp-3049	189	7	and	and	CCONJ
fnp-3049	189	8	distribution	distribution	NOUN
fnp-3049	189	9	of	of	ADP
fnp-3049	189	10	msdc-0160	msdc-0160	ADJ
fnp-3049	189	11	,	,	PUNCT
fnp-3049	189	12	we	we	PRON
fnp-3049	189	13	analyzed	analyze	VERB
fnp-3049	189	14	the	the	DET
fnp-3049	189	15	levels	level	NOUN
fnp-3049	189	16	of	of	ADP
fnp-3049	189	17	exposure	exposure	NOUN
fnp-3049	189	18	of	of	ADP
fnp-3049	189	19	msdc-0160	msdc-0160	ADJ
fnp-3049	189	20	,	,	PUNCT
fnp-3049	189	21	pioglitazone	pioglitazone	NOUN
fnp-3049	189	22	and	and	CCONJ
fnp-3049	189	23	its	its	PRON
fnp-3049	189	24	metabolites	metabolite	NOUN
fnp-3049	189	25	in	in	ADP
fnp-3049	189	26	rat	rat	NOUN
fnp-3049	189	27	plasma	plasma	NOUN
fnp-3049	189	28	,	,	PUNCT
fnp-3049	189	29	csf	csf	NOUN
fnp-3049	189	30	and	and	CCONJ
fnp-3049	189	31	brain	brain	NOUN
fnp-3049	189	32	mitochondria	mitochondria	NOUN
fnp-3049	189	33	20	20	NUM
fnp-3049	189	34	hours	hour	NOUN
fnp-3049	189	35	after	after	ADP
fnp-3049	189	36	administration	administration	NOUN
fnp-3049	189	37	(	(	PUNCT
fnp-3049	189	38	supplementary	supplementary	ADJ
fnp-3049	189	39	fig	fig	NOUN
fnp-3049	189	40	.	.	PUNCT
fnp-3049	190	1	1	1	NUM
fnp-3049	190	2	)	)	PUNCT
fnp-3049	190	3	.	.	PUNCT
fnp-3049	191	1	hydroxymitoglitazone	hydroxymitoglitazone	NOUN
fnp-3049	191	2	,	,	PUNCT
fnp-3049	191	3	the	the	DET
fnp-3049	191	4	active	active	ADJ
fnp-3049	191	5	metabolite	metabolite	NOUN
fnp-3049	191	6	of	of	ADP
fnp-3049	191	7	msdc-0160	msdc-0160	NOUN
fnp-3049	191	8	,	,	PUNCT
fnp-3049	191	9	was	be	AUX
fnp-3049	191	10	found	find	VERB
fnp-3049	191	11	at	at	ADP
fnp-3049	191	12	higher	high	ADJ
fnp-3049	191	13	levels	level	NOUN
fnp-3049	191	14	,	,	PUNCT
fnp-3049	191	15	compared	compare	VERB
fnp-3049	191	16	to	to	ADP
fnp-3049	191	17	pioglitazone	pioglitazone	NOUN
fnp-3049	191	18	metabolites	metabolite	NOUN
fnp-3049	191	19	,	,	PUNCT
fnp-3049	191	20	in	in	ADP
fnp-3049	191	21	plasma	plasma	NOUN
fnp-3049	191	22	and	and	CCONJ
fnp-3049	191	23	csf	csf	PROPN
fnp-3049	191	24	.	.	PROPN
fnp-3049	192	1	in	in	ADP
fnp-3049	192	2	brain	brain	NOUN
fnp-3049	192	3	mitochondria	mitochondria	NOUN
fnp-3049	192	4	hydroxymitoglitazone	hydroxymitoglitazone	PROPN
fnp-3049	192	5	was	be	AUX
fnp-3049	192	6	also	also	ADV
fnp-3049	192	7	found	find	VERB
fnp-3049	192	8	at	at	ADP
fnp-3049	192	9	higher	high	ADJ
fnp-3049	192	10	levels	level	NOUN
fnp-3049	192	11	then	then	ADV
fnp-3049	192	12	pioglitazone	pioglitazone	NOUN
fnp-3049	192	13	-	-	PUNCT
fnp-3049	192	14	oh	oh	NOUN
fnp-3049	192	15	or	or	CCONJ
fnp-3049	192	16	other	other	ADJ
fnp-3049	192	17	metabolites	metabolite	NOUN
fnp-3049	192	18	,	,	PUNCT
fnp-3049	192	19	showing	show	VERB
fnp-3049	192	20	its	its	PRON
fnp-3049	192	21	interaction	interaction	NOUN
fnp-3049	192	22	with	with	ADP
fnp-3049	192	23	brain	brain	NOUN
fnp-3049	192	24	mitochondria	mitochondria	NOUN
fnp-3049	192	25	but	but	CCONJ
fnp-3049	192	26	also	also	ADV
fnp-3049	192	27	suggesting	suggest	VERB
fnp-3049	192	28	that	that	SCONJ
fnp-3049	192	29	the	the	DET
fnp-3049	192	30	interaction	interaction	NOUN
fnp-3049	192	31	of	of	ADP
fnp-3049	192	32	msdc-0160	msdc-0160	ADJ
fnp-3049	192	33	metabolites	metabolite	NOUN
fnp-3049	192	34	with	with	ADP
fnp-3049	192	35	mitochondria	mitochondria	NOUN
fnp-3049	192	36	is	be	AUX
fnp-3049	192	37	stronger	strong	ADJ
fnp-3049	192	38	compared	compare	VERB
fnp-3049	192	39	to	to	ADP
fnp-3049	192	40	pioglitazone	pioglitazone	NOUN
fnp-3049	192	41	metabolites	metabolite	NOUN
fnp-3049	192	42	(	(	PUNCT
fnp-3049	192	43	supplementary	supplementary	ADJ
fnp-3049	192	44	fig	fig	NOUN
fnp-3049	192	45	.	.	PUNCT
fnp-3049	193	1	1	1	NUM
fnp-3049	193	2	)	)	PUNCT
fnp-3049	193	3	.	.	PUNCT
fnp-3049	194	1	during	during	ADP
fnp-3049	194	2	the	the	DET
fnp-3049	194	3	time	time	NOUN
fnp-3049	194	4	of	of	ADP
fnp-3049	194	5	chow	chow	PROPN
fnp-3049	194	6	administration	administration	NOUN
fnp-3049	194	7	,	,	PUNCT
fnp-3049	194	8	we	we	PRON
fnp-3049	194	9	did	do	AUX
fnp-3049	194	10	not	not	PART
fnp-3049	194	11	observe	observe	VERB
fnp-3049	194	12	any	any	DET
fnp-3049	194	13	differences	difference	NOUN
fnp-3049	194	14	in	in	ADP
fnp-3049	194	15	animal	animal	NOUN
fnp-3049	194	16	body	body	NOUN
fnp-3049	194	17	weight	weight	NOUN
fnp-3049	194	18	or	or	CCONJ
fnp-3049	194	19	chow	chow	NOUN
fnp-3049	194	20	consumption	consumption	NOUN
fnp-3049	194	21	(	(	PUNCT
fnp-3049	194	22	supplementary	supplementary	ADJ
fnp-3049	194	23	fig	fig	NOUN
fnp-3049	194	24	.	.	PUNCT
fnp-3049	195	1	2a	2a	NUM
fnp-3049	195	2	,	,	PUNCT
fnp-3049	195	3	b	b	NOUN
fnp-3049	195	4	)	)	PUNCT
fnp-3049	195	5	.	.	PUNCT
fnp-3049	196	1	at	at	ADP
fnp-3049	196	2	the	the	DET
fnp-3049	196	3	four	four	NUM
fnp-3049	196	4	-	-	PUNCT
fnp-3049	196	5	month	month	NOUN
fnp-3049	196	6	timepoint	timepoint	NOUN
fnp-3049	196	7	,	,	PUNCT
fnp-3049	196	8	plasma	plasma	NOUN
fnp-3049	196	9	was	be	AUX
fnp-3049	196	10	collected	collect	VERB
fnp-3049	196	11	and	and	CCONJ
fnp-3049	196	12	the	the	DET
fnp-3049	196	13	presence	presence	NOUN
fnp-3049	196	14	of	of	ADP
fnp-3049	196	15	hydroxymitoglitazone	hydroxymitoglitazone	NOUN
fnp-3049	196	16	(	(	PUNCT
fnp-3049	196	17	msdc-0160	msdc-0160	ADJ
fnp-3049	196	18	metabolite	metabolite	NOUN
fnp-3049	196	19	)	)	PUNCT
fnp-3049	196	20	was	be	AUX
fnp-3049	196	21	quantified	quantify	VERB
fnp-3049	196	22	(	(	PUNCT
fnp-3049	196	23	supplementary	supplementary	ADJ
fnp-3049	196	24	fig	fig	NOUN
fnp-3049	196	25	.	.	PUNCT
fnp-3049	197	1	2c	2c	NUM
fnp-3049	197	2	)	)	PUNCT
fnp-3049	198	1	,	,	PUNCT
fnp-3049	198	2	showing	show	VERB
fnp-3049	198	3	the	the	DET
fnp-3049	198	4	presence	presence	NOUN
fnp-3049	198	5	and	and	CCONJ
fnp-3049	198	6	metabolization	metabolization	NOUN
fnp-3049	198	7	of	of	ADP
fnp-3049	198	8	msdc-0160	msdc-0160	NOUN
fnp-3049	198	9	at	at	ADP
fnp-3049	198	10	expected	expect	VERB
fnp-3049	198	11	levels	level	NOUN
fnp-3049	198	12	.	.	PUNCT
fnp-3049	199	1	motor	motor	NOUN
fnp-3049	199	2	behavior	behavior	NOUN
fnp-3049	199	3	was	be	AUX
fnp-3049	199	4	examined	examine	VERB
fnp-3049	199	5	four	four	NUM
fnp-3049	199	6	months	month	NOUN
fnp-3049	199	7	after	after	ADP
fnp-3049	199	8	viral	viral	ADJ
fnp-3049	199	9	transduction	transduction	NOUN
fnp-3049	199	10	using	use	VERB
fnp-3049	199	11	the	the	DET
fnp-3049	199	12	cylinder	cylinder	NOUN
fnp-3049	199	13	test	test	NOUN
fnp-3049	199	14	.	.	PUNCT
fnp-3049	200	1	no	no	DET
fnp-3049	200	2	difference	difference	NOUN
fnp-3049	200	3	in	in	ADP
fnp-3049	200	4	motor	motor	NOUN
fnp-3049	200	5	behavior	behavior	NOUN
fnp-3049	200	6	was	be	AUX
fnp-3049	200	7	apparent	apparent	ADJ
fnp-3049	200	8	between	between	ADP
fnp-3049	200	9	any	any	PRON
fnp-3049	200	10	of	of	ADP
fnp-3049	200	11	the	the	DET
fnp-3049	200	12	experimental	experimental	ADJ
fnp-3049	200	13	groups	group	NOUN
fnp-3049	200	14	,	,	PUNCT
fnp-3049	200	15	nor	nor	CCONJ
fnp-3049	200	16	did	do	AUX
fnp-3049	200	17	we	we	PRON
fnp-3049	200	18	observe	observe	VERB
fnp-3049	200	19	any	any	DET
fnp-3049	200	20	statistically	statistically	ADV
fnp-3049	200	21	significant	significant	ADJ
fnp-3049	200	22	differences	difference	NOUN
fnp-3049	200	23	between	between	ADP
fnp-3049	200	24	placebo	placebo	NOUN
fnp-3049	200	25	or	or	CCONJ
fnp-3049	200	26	msdc-0160	msdc-0160	ADJ
fnp-3049	200	27	treated	treat	VERB
fnp-3049	200	28	groups	group	NOUN
fnp-3049	200	29	(	(	PUNCT
fnp-3049	200	30	supplementary	supplementary	ADJ
fnp-3049	200	31	fig	fig	NOUN
fnp-3049	200	32	.	.	PUNCT
fnp-3049	201	1	3	3	NUM
fnp-3049	201	2	)	)	PUNCT
fnp-3049	201	3	.	.	PUNCT
fnp-3049	202	1	when	when	SCONJ
fnp-3049	202	2	assessing	assess	VERB
fnp-3049	202	3	the	the	DET
fnp-3049	202	4	total	total	ADJ
fnp-3049	202	5	number	number	NOUN
fnp-3049	202	6	of	of	ADP
fnp-3049	202	7	thand	thand	PROPN
fnp-3049	202	8	nissl	nissl	ADJ
fnp-3049	202	9	-	-	PUNCT
fnp-3049	202	10	positive	positive	ADJ
fnp-3049	202	11	neurons	neuron	NOUN
fnp-3049	202	12	in	in	ADP
fnp-3049	202	13	the	the	DET
fnp-3049	202	14	sn	sn	NOUN
fnp-3049	202	15	via	via	ADP
fnp-3049	202	16	stereology	stereology	NOUN
fnp-3049	202	17	we	we	PRON
fnp-3049	202	18	find	find	VERB
fnp-3049	202	19	a	a	DET
fnp-3049	202	20	significant	significant	ADJ
fnp-3049	202	21	decrease	decrease	NOUN
fnp-3049	202	22	in	in	ADP
fnp-3049	202	23	thand	thand	PROPN
fnp-3049	202	24	nissl	nissl	ADJ
fnp-3049	202	25	-	-	PUNCT
fnp-3049	202	26	positive	positive	ADJ
fnp-3049	202	27	cells	cell	NOUN
fnp-3049	202	28	between	between	ADP
fnp-3049	202	29	the	the	DET
fnp-3049	202	30	αsyn	αsyn	PROPN
fnp-3049	202	31	high	high	ADJ
fnp-3049	202	32	group	group	NOUN
fnp-3049	202	33	and	and	CCONJ
fnp-3049	202	34	all	all	DET
fnp-3049	202	35	other	other	ADJ
fnp-3049	202	36	experimental	experimental	ADJ
fnp-3049	202	37	treatment	treatment	NOUN
fnp-3049	202	38	groups	group	NOUN
fnp-3049	202	39	(	(	PUNCT
fnp-3049	202	40	fig	fig	NOUN
fnp-3049	202	41	.	.	PUNCT
fnp-3049	203	1	1a	1a	PROPN
fnp-3049	203	2	-	-	PUNCT
fnp-3049	203	3	b	b	NOUN
fnp-3049	203	4	)	)	PUNCT
fnp-3049	203	5	,	,	PUNCT
fnp-3049	203	6	suggesting	suggest	VERB
fnp-3049	203	7	dose	dose	NOUN
fnp-3049	203	8	-	-	PUNCT
fnp-3049	203	9	dependent	dependent	ADJ
fnp-3049	203	10	neurotoxic	neurotoxic	ADJ
fnp-3049	203	11	effects	effect	NOUN
fnp-3049	203	12	of	of	ADP
fnp-3049	203	13	αsyn	αsyn	ADJ
fnp-3049	203	14	expression	expression	NOUN
fnp-3049	203	15	.	.	PUNCT
fnp-3049	204	1	no	no	DET
fnp-3049	204	2	cell	cell	NOUN
fnp-3049	204	3	loss	loss	NOUN
fnp-3049	204	4	was	be	AUX
fnp-3049	204	5	observed	observe	VERB
fnp-3049	204	6	in	in	ADP
fnp-3049	204	7	the	the	DET
fnp-3049	204	8	gfp	gfp	PROPN
fnp-3049	204	9	group	group	NOUN
fnp-3049	204	10	,	,	PUNCT
fnp-3049	204	11	showing	show	VERB
fnp-3049	204	12	that	that	SCONJ
fnp-3049	204	13	no	no	DET
fnp-3049	204	14	toxic	toxic	ADJ
fnp-3049	204	15	effects	effect	NOUN
fnp-3049	204	16	are	be	AUX
fnp-3049	204	17	due	due	ADJ
fnp-3049	204	18	to	to	ADP
fnp-3049	204	19	the	the	DET
fnp-3049	204	20	viral	viral	ADJ
fnp-3049	204	21	vector	vector	NOUN
fnp-3049	204	22	itself	itself	PRON
fnp-3049	204	23	.	.	PUNCT
fnp-3049	205	1	in	in	ADP
fnp-3049	205	2	addition	addition	NOUN
fnp-3049	205	3	,	,	PUNCT
fnp-3049	205	4	when	when	SCONJ
fnp-3049	205	5	the	the	DET
fnp-3049	205	6	snpc	snpc	NOUN
fnp-3049	205	7	is	be	AUX
fnp-3049	205	8	separately	separately	ADV
fnp-3049	205	9	analyzed	analyze	VERB
fnp-3049	205	10	for	for	ADP
fnp-3049	205	11	its	its	PRON
fnp-3049	205	12	anterior	anterior	NOUN
fnp-3049	205	13	(	(	PUNCT
fnp-3049	205	14	bregma	bregma	NOUN
fnp-3049	205	15	-4.8	-4.8	VERB
fnp-3049	205	16	mm	mm	NOUN
fnp-3049	205	17	)	)	PUNCT
fnp-3049	205	18	and	and	CCONJ
fnp-3049	205	19	posterior	posterior	ADJ
fnp-3049	205	20	(	(	PUNCT
fnp-3049	205	21	bregma	bregma	NOUN
fnp-3049	205	22	-6.2	-6.2	NOUN
fnp-3049	205	23	mm	mm	PROPN
fnp-3049	205	24	)	)	PUNCT
fnp-3049	205	25	areas	area	NOUN
fnp-3049	205	26	,	,	PUNCT
fnp-3049	205	27	th	th	X
fnp-3049	205	28	loss	loss	NOUN
fnp-3049	205	29	in	in	ADP
fnp-3049	205	30	the	the	DET
fnp-3049	205	31	anterior	anterior	NOUN
fnp-3049	205	32	is	be	AUX
fnp-3049	205	33	much	much	ADV
fnp-3049	205	34	more	more	ADV
fnp-3049	205	35	significant	significant	ADJ
fnp-3049	205	36	compared	compare	VERB
fnp-3049	205	37	to	to	ADP
fnp-3049	205	38	the	the	DET
fnp-3049	205	39	posterior	posterior	ADJ
fnp-3049	205	40	region	region	NOUN
fnp-3049	205	41	(	(	PUNCT
fnp-3049	205	42	supplementary	supplementary	ADJ
fnp-3049	205	43	fig	fig	NOUN
fnp-3049	205	44	.	.	PUNCT
fnp-3049	206	1	4	4	NUM
fnp-3049	206	2	a	a	DET
fnp-3049	206	3	-	-	PUNCT
fnp-3049	206	4	d	d	NOUN
fnp-3049	206	5	)	)	PUNCT
fnp-3049	206	6	.	.	PUNCT
fnp-3049	207	1	this	this	PRON
fnp-3049	207	2	indicates	indicate	VERB
fnp-3049	207	3	that	that	SCONJ
fnp-3049	207	4	αsyn	αsyn	ADJ
fnp-3049	207	5	expression	expression	NOUN
fnp-3049	207	6	from	from	ADP
fnp-3049	207	7	the	the	DET
fnp-3049	207	8	overexpressing	overexpresse	VERB
fnp-3049	207	9	αsyn	αsyn	ADJ
fnp-3049	207	10	vector	vector	NOUN
fnp-3049	207	11	is	be	AUX
fnp-3049	207	12	higher	high	ADJ
fnp-3049	207	13	in	in	ADP
fnp-3049	207	14	the	the	DET
fnp-3049	207	15	anterior	anterior	ADJ
fnp-3049	207	16	snpc	snpc	NOUN
fnp-3049	207	17	since	since	SCONJ
fnp-3049	207	18	it	it	PRON
fnp-3049	207	19	is	be	AUX
fnp-3049	207	20	adjacent	adjacent	ADJ
fnp-3049	207	21	to	to	ADP
fnp-3049	207	22	the	the	DET
fnp-3049	207	23	injection	injection	NOUN
fnp-3049	207	24	site	site	NOUN
fnp-3049	207	25	,	,	PUNCT
fnp-3049	207	26	and	and	CCONJ
fnp-3049	207	27	lower	low	ADJ
fnp-3049	207	28	in	in	ADP
fnp-3049	207	29	the	the	DET
fnp-3049	207	30	posterior	posterior	ADJ
fnp-3049	207	31	portion	portion	NOUN
fnp-3049	207	32	,	,	PUNCT
fnp-3049	207	33	which	which	PRON
fnp-3049	207	34	again	again	ADV
fnp-3049	207	35	confirms	confirm	VERB
fnp-3049	207	36	vector	vector	NOUN
fnp-3049	207	37	-	-	PUNCT
fnp-3049	207	38	driven	drive	VERB
fnp-3049	207	39	αsyn	αsyn	NOUN
fnp-3049	207	40	neurotoxic	neurotoxic	ADJ
fnp-3049	207	41	effects	effect	NOUN
fnp-3049	207	42	with	with	ADP
fnp-3049	207	43	no	no	DET
fnp-3049	207	44	neurotoxicity	neurotoxicity	NOUN
fnp-3049	207	45	observed	observe	VERB
fnp-3049	207	46	for	for	ADP
fnp-3049	207	47	the	the	DET
fnp-3049	207	48	gfp	gfp	PROPN
fnp-3049	207	49	control	control	PROPN
fnp-3049	207	50	group	group	PROPN
fnp-3049	207	51	.	.	PUNCT
fnp-3049	208	1	next	next	ADV
fnp-3049	208	2	,	,	PUNCT
fnp-3049	208	3	we	we	PRON
fnp-3049	208	4	performed	perform	VERB
fnp-3049	208	5	stereological	stereological	ADJ
fnp-3049	208	6	counts	count	NOUN
fnp-3049	208	7	of	of	ADP
fnp-3049	208	8	nigral	nigral	ADJ
fnp-3049	208	9	cells	cell	NOUN
fnp-3049	208	10	positive	positive	ADJ
fnp-3049	208	11	for	for	ADP
fnp-3049	208	12	phosphorylated	phosphorylate	VERB
fnp-3049	208	13	αsyn	αsyn	NOUN
fnp-3049	208	14	(	(	PUNCT
fnp-3049	208	15	αsyn	αsyn	PROPN
fnp-3049	208	16	pser129	pser129	PROPN
fnp-3049	208	17	)	)	PUNCT
fnp-3049	208	18	(	(	PUNCT
fnp-3049	208	19	fig	fig	NOUN
fnp-3049	208	20	.	.	PUNCT
fnp-3049	208	21	2a	2a	NUM
fnp-3049	208	22	)	)	PUNCT
fnp-3049	208	23	.	.	PUNCT
fnp-3049	209	1	unexpectedly	unexpectedly	ADV
fnp-3049	209	2	,	,	PUNCT
fnp-3049	209	3	in	in	ADP
fnp-3049	209	4	the	the	DET
fnp-3049	209	5	αsyn	αsyn	PROPN
fnp-3049	209	6	low	low	ADJ
fnp-3049	209	7	group	group	NOUN
fnp-3049	209	8	,	,	PUNCT
fnp-3049	209	9	animals	animal	NOUN
fnp-3049	209	10	treated	treat	VERB
fnp-3049	209	11	with	with	ADP
fnp-3049	209	12	msdc-0160	msdc-0160	ADJ
fnp-3049	209	13	show	show	NOUN
fnp-3049	209	14	significantly	significantly	ADV
fnp-3049	209	15	more	more	ADV
fnp-3049	209	16	αsyn	αsyn	ADJ
fnp-3049	209	17	pser129	pser129	PROPN
fnp-3049	209	18	+	+	NUM
fnp-3049	209	19	cells	cell	NOUN
fnp-3049	209	20	compared	compare	VERB
fnp-3049	209	21	to	to	ADP
fnp-3049	209	22	the	the	DET
fnp-3049	209	23	placebo	placebo	NOUN
fnp-3049	209	24	group	group	NOUN
fnp-3049	209	25	(	(	PUNCT
fnp-3049	209	26	12132	12132	NUM
fnp-3049	209	27	versus	versus	ADP
fnp-3049	209	28	7918	7918	NUM
fnp-3049	209	29	cells	cell	NOUN
fnp-3049	209	30	,	,	PUNCT
fnp-3049	209	31	*	*	PUNCT
fnp-3049	209	32	*	*	PUNCT
fnp-3049	209	33	p	p	X
fnp-3049	209	34	=	=	NOUN
fnp-3049	209	35	0.002	0.002	NUM
fnp-3049	209	36	,	,	PUNCT
fnp-3049	209	37	negative	negative	ADJ
fnp-3049	209	38	binomial	binomial	ADJ
fnp-3049	209	39	regression	regression	NOUN
fnp-3049	209	40	with	with	ADP
fnp-3049	209	41	benjamini	benjamini	ADJ
fnp-3049	209	42	-	-	PUNCT
fnp-3049	209	43	hochberg	hochberg	ADJ
fnp-3049	209	44	multiple	multiple	ADJ
fnp-3049	209	45	testing	testing	NOUN
fnp-3049	209	46	adjustments	adjustment	NOUN
fnp-3049	209	47	,	,	PUNCT
fnp-3049	209	48	sem	sem	NOUN
fnp-3049	209	49	,	,	PUNCT
fnp-3049	209	50	n	n	PROPN
fnp-3049	209	51	=	=	SYM
fnp-3049	209	52	8)	8)	NUM
fnp-3049	209	53	(	(	PUNCT
fnp-3049	209	54	fig	fig	NOUN
fnp-3049	209	55	.	.	PUNCT
fnp-3049	209	56	2b	2b	NUM
fnp-3049	209	57	)	)	PUNCT
fnp-3049	209	58	.	.	PUNCT
fnp-3049	210	1	no	no	DET
fnp-3049	210	2	significant	significant	ADJ
fnp-3049	210	3	effect	effect	NOUN
fnp-3049	210	4	was	be	AUX
fnp-3049	210	5	detected	detect	VERB
fnp-3049	210	6	in	in	ADP
fnp-3049	210	7	the	the	DET
fnp-3049	210	8	αsyn	αsyn	PROPN
fnp-3049	210	9	high	high	ADJ
fnp-3049	210	10	group	group	NOUN
fnp-3049	210	11	between	between	ADP
fnp-3049	210	12	msdc-0160	msdc-0160	NOUN
fnp-3049	210	13	and	and	CCONJ
fnp-3049	210	14	the	the	DET
fnp-3049	210	15	placebo	placebo	NOUN
fnp-3049	210	16	group	group	NOUN
fnp-3049	210	17	.	.	PUNCT
fnp-3049	211	1	figure	figure	NOUN
fnp-3049	211	2	2	2	NUM
fnp-3049	211	3	.	.	PUNCT
fnp-3049	212	1	a	a	DET
fnp-3049	212	2	metabolic	metabolic	NOUN
fnp-3049	212	3	switch	switch	NOUN
fnp-3049	212	4	leads	lead	VERB
fnp-3049	212	5	to	to	ADP
fnp-3049	212	6	increased	increase	VERB
fnp-3049	212	7	αsyn	αsyn	ADJ
fnp-3049	212	8	pathology	pathology	NOUN
fnp-3049	212	9	in	in	ADP
fnp-3049	212	10	rat	rat	PROPN
fnp-3049	212	11	sn	sn	PROPN
fnp-3049	212	12	.	.	PUNCT
fnp-3049	213	1	a	a	DET
fnp-3049	213	2	)	)	PUNCT
fnp-3049	213	3	overview	overview	NOUN
fnp-3049	213	4	of	of	ADP
fnp-3049	213	5	pser129	pser129	PROPN
fnp-3049	213	6	-	-	ADJ
fnp-3049	213	7	αsyn	αsyn	ADJ
fnp-3049	213	8	positive	positive	ADJ
fnp-3049	213	9	cells	cell	NOUN
fnp-3049	213	10	in	in	ADP
fnp-3049	213	11	rat	rat	PROPN
fnp-3049	213	12	sn	sn	PROPN
fnp-3049	213	13	.	.	PUNCT
fnp-3049	214	1	scale	scale	NOUN
fnp-3049	214	2	bars	bar	NOUN
fnp-3049	214	3	for	for	ADP
fnp-3049	214	4	higher	high	ADJ
fnp-3049	214	5	and	and	CCONJ
fnp-3049	214	6	lower	low	ADJ
fnp-3049	214	7	magnification	magnification	NOUN
fnp-3049	214	8	represents	represent	VERB
fnp-3049	214	9	450	450	NUM
fnp-3049	214	10	μm	μm	NUM
fnp-3049	214	11	and	and	CCONJ
fnp-3049	214	12	100	100	NUM
fnp-3049	214	13	μm	μm	NUM
fnp-3049	214	14	,	,	PUNCT
fnp-3049	214	15	respectively	respectively	ADV
fnp-3049	214	16	.	.	PUNCT
fnp-3049	215	1	b	b	X
fnp-3049	215	2	)	)	PUNCT
fnp-3049	215	3	stereological	stereological	ADJ
fnp-3049	215	4	quantification	quantification	NOUN
fnp-3049	215	5	of	of	ADP
fnp-3049	215	6	αsyn	αsyn	ADJ
fnp-3049	215	7	pser129	pser129	PROPN
fnp-3049	215	8	positive	positive	ADJ
fnp-3049	215	9	cells	cell	NOUN
fnp-3049	215	10	in	in	ADP
fnp-3049	215	11	rat	rat	PROPN
fnp-3049	215	12	sn	sn	PROPN
fnp-3049	215	13	.	.	PUNCT
fnp-3049	216	1	treatment	treatment	NOUN
fnp-3049	216	2	with	with	ADP
fnp-3049	216	3	msdc-0160	msdc-0160	ADJ
fnp-3049	216	4	leads	lead	NOUN
fnp-3049	216	5	to	to	ADP
fnp-3049	216	6	a	a	DET
fnp-3049	216	7	significant	significant	ADJ
fnp-3049	216	8	increase	increase	NOUN
fnp-3049	216	9	in	in	ADP
fnp-3049	216	10	phosphorylated	phosphorylate	VERB
fnp-3049	216	11	cells	cell	NOUN
fnp-3049	216	12	in	in	ADP
fnp-3049	216	13	the	the	DET
fnp-3049	216	14	αsyn	αsyn	PROPN
fnp-3049	216	15	low	low	ADJ
fnp-3049	216	16	group	group	NOUN
fnp-3049	216	17	compared	compare	VERB
fnp-3049	216	18	to	to	ADP
fnp-3049	216	19	placebo	placebo	NOUN
fnp-3049	216	20	(	(	PUNCT
fnp-3049	216	21	n	n	NOUN
fnp-3049	216	22	=	=	SYM
fnp-3049	216	23	8	8	NUM
fnp-3049	216	24	,	,	PUNCT
fnp-3049	216	25	sem	sem	NOUN
fnp-3049	216	26	,	,	PUNCT
fnp-3049	216	27	*	*	PUNCT
fnp-3049	216	28	*	*	PUNCT
fnp-3049	216	29	p	p	X
fnp-3049	216	30	<	<	X
fnp-3049	216	31	0.01	0.01	NUM
fnp-3049	216	32	and	and	CCONJ
fnp-3049	216	33	*	*	NOUN
fnp-3049	216	34	*	*	PUNCT
fnp-3049	216	35	*	*	PUNCT
fnp-3049	216	36	p	p	X
fnp-3049	216	37	<	<	X
fnp-3049	216	38	0.001	0.001	NUM
fnp-3049	216	39	,	,	PUNCT
fnp-3049	216	40	negative	negative	ADJ
fnp-3049	216	41	binomial	binomial	ADJ
fnp-3049	216	42	regression	regression	NOUN
fnp-3049	216	43	with	with	ADP
fnp-3049	216	44	benjamini	benjamini	ADJ
fnp-3049	216	45	-	-	PUNCT
fnp-3049	216	46	hochberg	hochberg	ADJ
fnp-3049	216	47	multiple	multiple	ADJ
fnp-3049	216	48	testing	testing	NOUN
fnp-3049	216	49	adjustments	adjustment	NOUN
fnp-3049	216	50	,	,	PUNCT
fnp-3049	216	51	sem	sem	NOUN
fnp-3049	216	52	,	,	PUNCT
fnp-3049	216	53	n	n	NOUN
fnp-3049	216	54	=	=	PUNCT
fnp-3049	216	55	8)	8)	NUM
fnp-3049	216	56	)	)	PUNCT
fnp-3049	216	57	.	.	PUNCT
fnp-3049	217	1	we	we	PRON
fnp-3049	217	2	further	far	ADV
fnp-3049	217	3	analyzed	analyze	VERB
fnp-3049	217	4	phosphorylated	phosphorylate	VERB
fnp-3049	217	5	levels	level	NOUN
fnp-3049	217	6	of	of	ADP
fnp-3049	217	7	αsyn	αsyn	NOUN
fnp-3049	217	8	via	via	ADP
fnp-3049	217	9	biochemical	biochemical	ADJ
fnp-3049	217	10	analyses	analysis	NOUN
fnp-3049	217	11	and	and	CCONJ
fnp-3049	217	12	found	find	VERB
fnp-3049	217	13	that	that	SCONJ
fnp-3049	217	14	both	both	CCONJ
fnp-3049	217	15	soluble	soluble	ADJ
fnp-3049	217	16	αsyn	αsyn	NOUN
fnp-3049	217	17	pser129	pser129	PROPN
fnp-3049	217	18	as	as	ADV
fnp-3049	217	19	well	well	ADV
fnp-3049	217	20	as	as	ADP
fnp-3049	217	21	1	1	NUM
fnp-3049	217	22	%	%	NOUN
fnp-3049	217	23	sarkosyl	sarkosyl	NOUN
fnp-3049	217	24	insoluble	insoluble	ADJ
fnp-3049	217	25	αsyn	αsyn	NOUN
fnp-3049	217	26	pser129	pser129	PROPN
fnp-3049	217	27	(	(	PUNCT
fnp-3049	217	28	1	1	NUM
fnp-3049	217	29	%	%	NOUN
fnp-3049	217	30	p129	p129	PROPN
fnp-3049	217	31	-	-	PUNCT
fnp-3049	217	32	αsyn	αsyn	NOUN
fnp-3049	217	33	)	)	PUNCT
fnp-3049	217	34	are	be	AUX
fnp-3049	217	35	increased	increase	VERB
fnp-3049	217	36	in	in	ADP
fnp-3049	217	37	the	the	DET
fnp-3049	217	38	msdc-0160	msdc-0160	ADJ
fnp-3049	217	39	treated	treat	VERB
fnp-3049	217	40	animals	animal	NOUN
fnp-3049	217	41	compared	compare	VERB
fnp-3049	217	42	to	to	ADP
fnp-3049	217	43	the	the	DET
fnp-3049	217	44	placebo	placebo	NOUN
fnp-3049	217	45	group	group	NOUN
fnp-3049	217	46	(	(	PUNCT
fnp-3049	217	47	*	*	PUNCT
fnp-3049	217	48	p	p	X
fnp-3049	217	49	=	=	NOUN
fnp-3049	217	50	0.046	0.046	NUM
fnp-3049	217	51	,	,	PUNCT
fnp-3049	217	52	95	95	NUM
fnp-3049	217	53	%	%	NOUN
fnp-3049	217	54	ci	ci	NOUN
fnp-3049	217	55	0.039	0.039	NUM
fnp-3049	217	56	–	–	PUNCT
fnp-3049	217	57	0.471	0.471	NUM
fnp-3049	217	58	,	,	PUNCT
fnp-3049	217	59	square	square	ADJ
fnp-3049	217	60	-	-	PUNCT
fnp-3049	217	61	root	root	NOUN
fnp-3049	217	62	linear	linear	PROPN
fnp-3049	217	63	regression	regression	NOUN
fnp-3049	217	64	,	,	PUNCT
fnp-3049	217	65	sem	sem	NOUN
fnp-3049	217	66	,	,	PUNCT
fnp-3049	217	67	n	n	NOUN
fnp-3049	217	68	=	=	SYM
fnp-3049	217	69	6	6	NUM
fnp-3049	217	70	for	for	ADP
fnp-3049	217	71	soluble	soluble	ADJ
fnp-3049	217	72	αsyn	αsyn	NOUN
fnp-3049	217	73	pser129	pser129	PROPN
fnp-3049	217	74	and	and	CCONJ
fnp-3049	217	75	*	*	NOUN
fnp-3049	217	76	p	p	X
fnp-3049	217	77	=	=	NOUN
fnp-3049	217	78	0.013	0.013	NUM
fnp-3049	217	79	,	,	PUNCT
fnp-3049	217	80	95	95	NUM
fnp-3049	217	81	%	%	NOUN
fnp-3049	217	82	ci	ci	NOUN
fnp-3049	217	83	0.129	0.129	NUM
fnp-3049	217	84	–	–	PUNCT
fnp-3049	217	85	0.691	0.691	NUM
fnp-3049	217	86	,	,	PUNCT
fnp-3049	217	87	square	square	ADJ
fnp-3049	217	88	-	-	PUNCT
fnp-3049	217	89	root	root	NOUN
fnp-3049	217	90	linear	linear	PROPN
fnp-3049	217	91	regression	regression	NOUN
fnp-3049	217	92	,	,	PUNCT
fnp-3049	217	93	sem	sem	NOUN
fnp-3049	217	94	,	,	PUNCT
fnp-3049	217	95	n	n	NOUN
fnp-3049	217	96	=	=	NUM
fnp-3049	217	97	6	6	NUM
fnp-3049	217	98	for	for	ADP
fnp-3049	217	99	1	1	NUM
fnp-3049	217	100	%	%	NOUN
fnp-3049	217	101	sarkosyl	sarkosyl	NOUN
fnp-3049	217	102	insoluble	insoluble	ADJ
fnp-3049	217	103	αsyn	αsyn	NOUN
fnp-3049	217	104	pser129	pser129	PROPN
fnp-3049	217	105	)	)	PUNCT
fnp-3049	217	106	(	(	PUNCT
fnp-3049	217	107	fig	fig	NOUN
fnp-3049	217	108	.	.	PUNCT
fnp-3049	218	1	3e	3e	NOUN
fnp-3049	218	2	,	,	PUNCT
fnp-3049	218	3	f	f	NOUN
fnp-3049	218	4	)	)	PUNCT
fnp-3049	218	5	.	.	PUNCT
fnp-3049	219	1	this	this	DET
fnp-3049	219	2	increase	increase	NOUN
fnp-3049	219	3	was	be	AUX
fnp-3049	219	4	observed	observe	VERB
fnp-3049	219	5	in	in	ADP
fnp-3049	219	6	the	the	DET
fnp-3049	219	7	αsyn	αsyn	PROPN
fnp-3049	219	8	high	high	ADJ
fnp-3049	219	9	group	group	NOUN
fnp-3049	219	10	between	between	ADP
fnp-3049	219	11	msdc-0160	msdc-0160	ADJ
fnp-3049	219	12	and	and	CCONJ
fnp-3049	219	13	placebo	placebo	NOUN
fnp-3049	219	14	animals	animal	NOUN
fnp-3049	219	15	whereas	whereas	SCONJ
fnp-3049	219	16	a	a	DET
fnp-3049	219	17	similar	similar	ADJ
fnp-3049	219	18	trend	trend	NOUN
fnp-3049	219	19	was	be	AUX
fnp-3049	219	20	noticeable	noticeable	ADJ
fnp-3049	219	21	in	in	ADP
fnp-3049	219	22	the	the	DET
fnp-3049	219	23	αsyn	αsyn	PROPN
fnp-3049	219	24	low	low	ADJ
fnp-3049	219	25	group	group	NOUN
fnp-3049	219	26	between	between	ADP
fnp-3049	219	27	treatment	treatment	NOUN
fnp-3049	219	28	conditions	condition	NOUN
fnp-3049	219	29	(	(	PUNCT
fnp-3049	219	30	fig	fig	NOUN
fnp-3049	219	31	.	.	PUNCT
fnp-3049	220	1	3e	3e	NOUN
fnp-3049	220	2	,	,	PUNCT
fnp-3049	220	3	f	f	NOUN
fnp-3049	220	4	)	)	PUNCT
fnp-3049	220	5	.	.	PUNCT
fnp-3049	221	1	this	this	PRON
fnp-3049	221	2	indicates	indicate	VERB
fnp-3049	221	3	that	that	SCONJ
fnp-3049	221	4	administration	administration	NOUN
fnp-3049	221	5	of	of	ADP
fnp-3049	221	6	msdc-0160	msdc-0160	ADJ
fnp-3049	221	7	results	result	NOUN
fnp-3049	221	8	in	in	ADP
fnp-3049	221	9	increased	increase	VERB
fnp-3049	221	10	αsyn	αsyn	ADJ
fnp-3049	221	11	aggregation	aggregation	NOUN
fnp-3049	221	12	in	in	ADP
fnp-3049	221	13	the	the	DET
fnp-3049	221	14	slowly	slowly	ADV
fnp-3049	221	15	progressing	progress	VERB
fnp-3049	221	16	viral	viral	ADJ
fnp-3049	221	17	vector	vector	NOUN
fnp-3049	221	18	-	-	PUNCT
fnp-3049	221	19	based	base	VERB
fnp-3049	221	20	model	model	NOUN
fnp-3049	221	21	that	that	PRON
fnp-3049	221	22	overexpresses	overexpresse	VERB
fnp-3049	221	23	αsyn	αsyn	PROPN
fnp-3049	221	24	.	.	PUNCT
fnp-3049	222	1	figure	figure	VERB
fnp-3049	222	2	3	3	NUM
fnp-3049	222	3	.	.	PUNCT
fnp-3049	223	1	αsyn	αsyn	PROPN
fnp-3049	223	2	aggregation	aggregation	NOUN
fnp-3049	223	3	is	be	AUX
fnp-3049	223	4	increased	increase	VERB
fnp-3049	223	5	in	in	ADP
fnp-3049	223	6	rat	rat	NOUN
fnp-3049	223	7	sn	sn	PROPN
fnp-3049	223	8	after	after	ADP
fnp-3049	223	9	inhibition	inhibition	NOUN
fnp-3049	223	10	of	of	ADP
fnp-3049	223	11	the	the	DET
fnp-3049	223	12	mpc	mpc	PROPN
fnp-3049	223	13	.	.	PUNCT
fnp-3049	224	1	a	a	PRON
fnp-3049	224	2	)	)	PUNCT
fnp-3049	224	3	inhibition	inhibition	NOUN
fnp-3049	224	4	of	of	ADP
fnp-3049	224	5	the	the	DET
fnp-3049	224	6	mpc	mpc	NOUN
fnp-3049	224	7	has	have	VERB
fnp-3049	224	8	no	no	DET
fnp-3049	224	9	effect	effect	NOUN
fnp-3049	224	10	on	on	ADP
fnp-3049	224	11	viral	viral	ADJ
fnp-3049	224	12	vector	vector	NOUN
fnp-3049	224	13	-	-	PUNCT
fnp-3049	224	14	mediated	mediate	VERB
fnp-3049	224	15	expression	expression	NOUN
fnp-3049	224	16	of	of	ADP
fnp-3049	224	17	gfp	gfp	PROPN
fnp-3049	224	18	.	.	PUNCT
fnp-3049	225	1	b	b	X
fnp-3049	225	2	)	)	PUNCT
fnp-3049	225	3	detection	detection	NOUN
fnp-3049	225	4	of	of	ADP
fnp-3049	225	5	total	total	ADJ
fnp-3049	225	6	levels	level	NOUN
fnp-3049	225	7	of	of	ADP
fnp-3049	225	8	αsyn	αsyn	NOUN
fnp-3049	225	9	in	in	ADP
fnp-3049	225	10	naïve	naïve	ADJ
fnp-3049	225	11	and	and	CCONJ
fnp-3049	225	12	experimental	experimental	ADJ
fnp-3049	225	13	conditions	condition	NOUN
fnp-3049	225	14	.	.	PUNCT
fnp-3049	226	1	αsyn	αsyn	ADJ
fnp-3049	226	2	overexpression	overexpression	NOUN
fnp-3049	226	3	leads	lead	VERB
fnp-3049	226	4	to	to	ADP
fnp-3049	226	5	a	a	DET
fnp-3049	226	6	4and	4and	NOUN
fnp-3049	226	7	6	6	NUM
fnp-3049	226	8	-	-	ADJ
fnp-3049	226	9	fold	fold	ADJ
fnp-3049	226	10	increase	increase	NOUN
fnp-3049	226	11	in	in	ADP
fnp-3049	226	12	αsyn	αsyn	PROPN
fnp-3049	226	13	low	low	ADJ
fnp-3049	226	14	and	and	CCONJ
fnp-3049	226	15	high	high	ADJ
fnp-3049	226	16	conditions	condition	NOUN
fnp-3049	226	17	compared	compare	VERB
fnp-3049	226	18	to	to	ADP
fnp-3049	226	19	naïve	naïve	ADJ
fnp-3049	226	20	rats	rat	NOUN
fnp-3049	226	21	.	.	PUNCT
fnp-3049	227	1	c	c	X
fnp-3049	227	2	,	,	PUNCT
fnp-3049	227	3	d	d	NOUN
fnp-3049	227	4	)	)	PUNCT
fnp-3049	227	5	isolation	isolation	NOUN
fnp-3049	227	6	of	of	ADP
fnp-3049	227	7	sequentially	sequentially	ADV
fnp-3049	227	8	extracted	extract	VERB
fnp-3049	227	9	soluble	soluble	ADJ
fnp-3049	227	10	and	and	CCONJ
fnp-3049	227	11	1	1	NUM
fnp-3049	227	12	%	%	NOUN
fnp-3049	227	13	sarkosyl	sarkosyl	NOUN
fnp-3049	227	14	insoluble	insoluble	ADJ
fnp-3049	227	15	human	human	ADJ
fnp-3049	227	16	αsyn	αsyn	NOUN
fnp-3049	227	17	(	(	PUNCT
fnp-3049	227	18	1	1	NUM
fnp-3049	227	19	%	%	NOUN
fnp-3049	227	20	hu	hu	NOUN
fnp-3049	227	21	-	-	PUNCT
fnp-3049	227	22	αsyn	αsyn	NOUN
fnp-3049	227	23	)	)	PUNCT
fnp-3049	227	24	shows	show	VERB
fnp-3049	227	25	no	no	DET
fnp-3049	227	26	significant	significant	ADJ
fnp-3049	227	27	differences	difference	NOUN
fnp-3049	227	28	in	in	ADP
fnp-3049	227	29	aggregated	aggregate	VERB
fnp-3049	227	30	αsyn	αsyn	NOUN
fnp-3049	227	31	after	after	ADP
fnp-3049	227	32	treatment	treatment	NOUN
fnp-3049	227	33	with	with	ADP
fnp-3049	227	34	msdc-0160	msdc-0160	NOUN
fnp-3049	227	35	.	.	PUNCT
fnp-3049	228	1	e	e	X
fnp-3049	228	2	,	,	PUNCT
fnp-3049	228	3	f	f	X
fnp-3049	228	4	)	)	PUNCT
fnp-3049	228	5	inhibition	inhibition	NOUN
fnp-3049	228	6	of	of	ADP
fnp-3049	228	7	mpc	mpc	NOUN
fnp-3049	228	8	leads	lead	VERB
fnp-3049	228	9	to	to	ADP
fnp-3049	228	10	significantly	significantly	ADV
fnp-3049	228	11	increased	increase	VERB
fnp-3049	228	12	levels	level	NOUN
fnp-3049	228	13	of	of	ADP
fnp-3049	228	14	soluble	soluble	ADJ
fnp-3049	228	15	and	and	CCONJ
fnp-3049	228	16	1	1	NUM
fnp-3049	228	17	%	%	NOUN
fnp-3049	228	18	sarkosyl	sarkosyl	NOUN
fnp-3049	228	19	insoluble	insoluble	ADJ
fnp-3049	228	20	αsyn	αsyn	NOUN
fnp-3049	228	21	pser129	pser129	PROPN
fnp-3049	228	22	(	(	PUNCT
fnp-3049	228	23	1	1	NUM
fnp-3049	228	24	%	%	NOUN
fnp-3049	228	25	p129	p129	PROPN
fnp-3049	228	26	-	-	PUNCT
fnp-3049	228	27	αsyn	αsyn	NOUN
fnp-3049	228	28	)	)	PUNCT
fnp-3049	228	29	in	in	ADP
fnp-3049	228	30	the	the	DET
fnp-3049	228	31	αsyn	αsyn	PROPN
fnp-3049	228	32	high	high	ADJ
fnp-3049	228	33	group	group	NOUN
fnp-3049	228	34	(	(	PUNCT
fnp-3049	228	35	n	n	NOUN
fnp-3049	228	36	=	=	SYM
fnp-3049	228	37	6	6	NUM
fnp-3049	228	38	,	,	PUNCT
fnp-3049	228	39	sem	sem	NOUN
fnp-3049	228	40	,	,	PUNCT
fnp-3049	228	41	*	*	PUNCT
fnp-3049	228	42	p	p	X
fnp-3049	228	43	<	<	X
fnp-3049	228	44	0.05	0.05	NUM
fnp-3049	228	45	square	square	ADJ
fnp-3049	228	46	-	-	PUNCT
fnp-3049	228	47	root	root	NOUN
fnp-3049	228	48	linear	linear	PROPN
fnp-3049	228	49	regression	regression	NOUN
fnp-3049	228	50	,	,	PUNCT
fnp-3049	228	51	sem	sem	NOUN
fnp-3049	228	52	,	,	PUNCT
fnp-3049	228	53	n	n	NOUN
fnp-3049	228	54	=	=	PROPN
fnp-3049	228	55	6	6	NUM
fnp-3049	228	56	)	)	PUNCT
fnp-3049	228	57	.	.	PUNCT
fnp-3049	229	1	g	g	NOUN
fnp-3049	229	2	)	)	PUNCT
fnp-3049	229	3	representative	representative	ADJ
fnp-3049	229	4	western	western	ADJ
fnp-3049	229	5	blot	blot	NOUN
fnp-3049	229	6	figures	figure	NOUN
fnp-3049	229	7	for	for	ADP
fnp-3049	229	8	different	different	ADJ
fnp-3049	229	9	conditions	condition	NOUN
fnp-3049	229	10	tested	test	VERB
fnp-3049	229	11	.	.	PUNCT
fnp-3049	230	1	αsyn	αsyn	PROPN
fnp-3049	230	2	has	have	AUX
fnp-3049	230	3	been	be	AUX
fnp-3049	230	4	shown	show	VERB
fnp-3049	230	5	to	to	PART
fnp-3049	230	6	bind	bind	VERB
fnp-3049	230	7	the	the	DET
fnp-3049	230	8	membrane	membrane	NOUN
fnp-3049	230	9	of	of	ADP
fnp-3049	230	10	mitochondria17	mitochondria17	NOUN
fnp-3049	230	11	.	.	PUNCT
fnp-3049	231	1	due	due	ADP
fnp-3049	231	2	to	to	ADP
fnp-3049	231	3	its	its	PRON
fnp-3049	231	4	membrane	membrane	NOUN
fnp-3049	231	5	curvature	curvature	NOUN
fnp-3049	231	6	and	and	CCONJ
fnp-3049	231	7	the	the	DET
fnp-3049	231	8	presence	presence	NOUN
fnp-3049	231	9	of	of	ADP
fnp-3049	231	10	the	the	DET
fnp-3049	231	11	negatively	negatively	ADV
fnp-3049	231	12	charged	charge	VERB
fnp-3049	231	13	cardiolipin	cardiolipin	NOUN
fnp-3049	231	14	in	in	ADP
fnp-3049	231	15	the	the	DET
fnp-3049	231	16	mitochondrial	mitochondrial	ADJ
fnp-3049	231	17	outer	outer	ADJ
fnp-3049	231	18	membrane	membrane	NOUN
fnp-3049	231	19	,	,	PUNCT
fnp-3049	231	20	αsyn	αsyn	PROPN
fnp-3049	231	21	has	have	VERB
fnp-3049	231	22	a	a	DET
fnp-3049	231	23	strong	strong	ADJ
fnp-3049	231	24	binding	bind	VERB
fnp-3049	231	25	affinity	affinity	NOUN
fnp-3049	231	26	for	for	ADP
fnp-3049	231	27	mitochondria18	mitochondria18	NOUN
fnp-3049	231	28	.	.	PUNCT
fnp-3049	232	1	aggregated	aggregate	VERB
fnp-3049	232	2	αsyn	αsyn	NOUN
fnp-3049	232	3	can	can	AUX
fnp-3049	232	4	disrupt	disrupt	VERB
fnp-3049	232	5	mitochondrial	mitochondrial	ADJ
fnp-3049	232	6	membrane	membrane	NOUN
fnp-3049	232	7	integrity	integrity	NOUN
fnp-3049	232	8	and	and	CCONJ
fnp-3049	232	9	lead	lead	VERB
fnp-3049	232	10	to	to	ADP
fnp-3049	232	11	toxicity19	toxicity19	NOUN
fnp-3049	232	12	.	.	PUNCT
fnp-3049	233	1	to	to	PART
fnp-3049	233	2	examine	examine	VERB
fnp-3049	233	3	why	why	SCONJ
fnp-3049	233	4	inhibiting	inhibit	VERB
fnp-3049	233	5	the	the	DET
fnp-3049	233	6	mpc	mpc	NOUN
fnp-3049	233	7	results	result	NOUN
fnp-3049	233	8	in	in	ADP
fnp-3049	233	9	more	more	ADJ
fnp-3049	233	10	αsyn	αsyn	ADJ
fnp-3049	233	11	aggregation	aggregation	NOUN
fnp-3049	233	12	,	,	PUNCT
fnp-3049	233	13	we	we	PRON
fnp-3049	233	14	investigated	investigate	VERB
fnp-3049	233	15	if	if	SCONJ
fnp-3049	233	16	altering	alter	VERB
fnp-3049	233	17	mitochondrial	mitochondrial	ADJ
fnp-3049	233	18	function	function	NOUN
fnp-3049	233	19	,	,	PUNCT
fnp-3049	233	20	or	or	CCONJ
fnp-3049	233	21	changing	change	VERB
fnp-3049	233	22	oxidative	oxidative	ADJ
fnp-3049	233	23	environment	environment	NOUN
fnp-3049	233	24	via	via	ADP
fnp-3049	233	25	msdc-0160	msdc-0160	ADJ
fnp-3049	233	26	affects	affect	VERB
fnp-3049	233	27	αsyn	αsyn	NOUN
fnp-3049	233	28	binding	bind	VERB
fnp-3049	233	29	or	or	CCONJ
fnp-3049	233	30	αsyn	αsyn	ADJ
fnp-3049	233	31	oxidation	oxidation	NOUN
fnp-3049	233	32	status	status	NOUN
fnp-3049	233	33	.	.	PUNCT
fnp-3049	234	1	stereological	stereological	ADJ
fnp-3049	234	2	quantifications	quantification	NOUN
fnp-3049	234	3	of	of	ADP
fnp-3049	234	4	the	the	DET
fnp-3049	234	5	snpc	snpc	NOUN
fnp-3049	234	6	for	for	ADP
fnp-3049	234	7	nitrated	nitrated	ADJ
fnp-3049	234	8	ni	ni	PROPN
fnp-3049	234	9	-	-	NOUN
fnp-3049	234	10	αsyn	αsyn	NOUN
fnp-3049	234	11	(	(	PUNCT
fnp-3049	234	12	ni	ni	NOUN
fnp-3049	234	13	-	-	PUNCT
fnp-3049	234	14	αsyn	αsyn	NOUN
fnp-3049	234	15	)	)	PUNCT
fnp-3049	234	16	shows	show	VERB
fnp-3049	234	17	that	that	SCONJ
fnp-3049	234	18	in	in	ADP
fnp-3049	234	19	the	the	DET
fnp-3049	234	20	αsyn	αsyn	PROPN
fnp-3049	234	21	low	low	ADJ
fnp-3049	234	22	group	group	NOUN
fnp-3049	234	23	,	,	PUNCT
fnp-3049	234	24	inhibiting	inhibit	VERB
fnp-3049	234	25	the	the	DET
fnp-3049	234	26	mpc	mpc	NOUN
fnp-3049	234	27	with	with	ADP
fnp-3049	234	28	msdc-0160	msdc-0160	ADJ
fnp-3049	234	29	leads	lead	NOUN
fnp-3049	234	30	to	to	ADP
fnp-3049	234	31	more	more	ADJ
fnp-3049	234	32	ni	ni	NOUN
fnp-3049	234	33	-	-	NOUN
fnp-3049	234	34	αsyn	αsyn	NOUN
fnp-3049	234	35	(	(	PUNCT
fnp-3049	234	36	*	*	PUNCT
fnp-3049	234	37	p	p	X
fnp-3049	234	38	=	=	PROPN
fnp-3049	234	39	0.021	0.021	NUM
fnp-3049	234	40	,	,	PUNCT
fnp-3049	234	41	95	95	NUM
fnp-3049	234	42	%	%	NOUN
fnp-3049	234	43	ci	ci	NOUN
fnp-3049	234	44	11.5	11.5	NUM
fnp-3049	234	45	%	%	NOUN
fnp-3049	234	46	–	–	PUNCT
fnp-3049	234	47	111.7	111.7	NUM
fnp-3049	234	48	%	%	NOUN
fnp-3049	234	49	more	more	ADJ
fnp-3049	234	50	after	after	ADP
fnp-3049	234	51	negative	negative	ADJ
fnp-3049	234	52	binomial	binomial	ADJ
fnp-3049	234	53	regression	regression	NOUN
fnp-3049	234	54	with	with	ADP
fnp-3049	234	55	benjamini	benjamini	ADJ
fnp-3049	234	56	-	-	PUNCT
fnp-3049	234	57	hochberg	hochberg	ADJ
fnp-3049	234	58	multiple	multiple	ADJ
fnp-3049	234	59	testing	testing	NOUN
fnp-3049	234	60	adjustments	adjustment	NOUN
fnp-3049	234	61	)	)	PUNCT
fnp-3049	234	62	,	,	PUNCT
fnp-3049	234	63	indicating	indicate	VERB
fnp-3049	234	64	that	that	SCONJ
fnp-3049	234	65	inhibiting	inhibit	VERB
fnp-3049	234	66	the	the	DET
fnp-3049	234	67	mpc	mpc	NOUN
fnp-3049	234	68	leads	lead	VERB
fnp-3049	234	69	to	to	ADP
fnp-3049	234	70	increased	increase	VERB
fnp-3049	234	71	oxidation	oxidation	NOUN
fnp-3049	234	72	of	of	ADP
fnp-3049	234	73	αsyn	αsyn	NOUN
fnp-3049	234	74	(	(	PUNCT
fnp-3049	234	75	fig	fig	NOUN
fnp-3049	234	76	.	.	PUNCT
fnp-3049	234	77	4	4	NUM
fnp-3049	234	78	)	)	PUNCT
fnp-3049	234	79	.	.	PUNCT
fnp-3049	235	1	since	since	SCONJ
fnp-3049	235	2	it	it	PRON
fnp-3049	235	3	has	have	AUX
fnp-3049	235	4	been	be	AUX
fnp-3049	235	5	shown	show	VERB
fnp-3049	235	6	that	that	SCONJ
fnp-3049	235	7	oxidation	oxidation	NOUN
fnp-3049	235	8	of	of	ADP
fnp-3049	235	9	αsyn	αsyn	NOUN
fnp-3049	235	10	can	can	AUX
fnp-3049	235	11	affect	affect	VERB
fnp-3049	235	12	αsyn	αsyn	ADJ
fnp-3049	235	13	aggregation	aggregation	NOUN
fnp-3049	235	14	,	,	PUNCT
fnp-3049	235	15	it	it	PRON
fnp-3049	235	16	raises	raise	VERB
fnp-3049	235	17	the	the	DET
fnp-3049	235	18	possibility	possibility	NOUN
fnp-3049	235	19	that	that	SCONJ
fnp-3049	235	20	in	in	ADP
fnp-3049	235	21	this	this	DET
fnp-3049	235	22	αsyn	αsyn	ADJ
fnp-3049	235	23	overexpression	overexpression	NOUN
fnp-3049	235	24	model	model	NOUN
fnp-3049	235	25	a	a	DET
fnp-3049	235	26	metabolic	metabolic	NOUN
fnp-3049	235	27	switch	switch	NOUN
fnp-3049	235	28	promotes	promote	VERB
fnp-3049	235	29	the	the	DET
fnp-3049	235	30	formation	formation	NOUN
fnp-3049	235	31	of	of	ADP
fnp-3049	235	32	insoluble	insoluble	ADJ
fnp-3049	235	33	assemblies	assembly	NOUN
fnp-3049	235	34	of	of	ADP
fnp-3049	235	35	αsyn	αsyn	NOUN
fnp-3049	235	36	by	by	ADP
fnp-3049	235	37	increasing	increase	VERB
fnp-3049	235	38	αsyn	αsyn	ADJ
fnp-3049	235	39	oxidation	oxidation	NOUN
fnp-3049	235	40	.	.	PUNCT
fnp-3049	236	1	figure	figure	NOUN
fnp-3049	236	2	4	4	NUM
fnp-3049	236	3	.	.	PUNCT
fnp-3049	237	1	ni	ni	ADJ
fnp-3049	237	2	-	-	ADJ
fnp-3049	237	3	αsyn	αsyn	PROPN
fnp-3049	237	4	increases	increase	VERB
fnp-3049	237	5	upon	upon	SCONJ
fnp-3049	237	6	msdc-0160	msdc-0160	ADJ
fnp-3049	237	7	treatment	treatment	NOUN
fnp-3049	237	8	.	.	PUNCT
fnp-3049	238	1	stereological	stereological	ADJ
fnp-3049	238	2	quantification	quantification	NOUN
fnp-3049	238	3	of	of	ADP
fnp-3049	238	4	ni	ni	ADJ
fnp-3049	238	5	-	-	ADJ
fnp-3049	238	6	αsyn	αsyn	ADJ
fnp-3049	238	7	positive	positive	ADJ
fnp-3049	238	8	cells	cell	NOUN
fnp-3049	238	9	in	in	ADP
fnp-3049	238	10	rat	rat	PROPN
fnp-3049	238	11	sn	sn	PROPN
fnp-3049	238	12	.	.	PUNCT
fnp-3049	239	1	treatment	treatment	NOUN
fnp-3049	239	2	with	with	ADP
fnp-3049	239	3	msdc-0160	msdc-0160	ADJ
fnp-3049	239	4	leads	lead	NOUN
fnp-3049	239	5	to	to	ADP
fnp-3049	239	6	a	a	DET
fnp-3049	239	7	significant	significant	ADJ
fnp-3049	239	8	increase	increase	NOUN
fnp-3049	239	9	in	in	ADP
fnp-3049	239	10	nitrated	nitrated	ADJ
fnp-3049	239	11	cells	cell	NOUN
fnp-3049	239	12	in	in	ADP
fnp-3049	239	13	the	the	DET
fnp-3049	239	14	αsyn	αsyn	PROPN
fnp-3049	239	15	low	low	ADJ
fnp-3049	239	16	group	group	NOUN
fnp-3049	239	17	compared	compare	VERB
fnp-3049	239	18	to	to	ADP
fnp-3049	239	19	placebo	placebo	NOUN
fnp-3049	239	20	(	(	PUNCT
fnp-3049	239	21	*	*	PUNCT
fnp-3049	239	22	p	p	X
fnp-3049	239	23	<	<	X
fnp-3049	239	24	0.05	0.05	NUM
fnp-3049	239	25	via	via	ADP
fnp-3049	239	26	negative	negative	ADJ
fnp-3049	239	27	binomial	binomial	ADJ
fnp-3049	239	28	regression	regression	NOUN
fnp-3049	239	29	with	with	ADP
fnp-3049	239	30	benjamini	benjamini	ADJ
fnp-3049	239	31	-	-	PUNCT
fnp-3049	239	32	hochberg	hochberg	ADJ
fnp-3049	239	33	multiple	multiple	ADJ
fnp-3049	239	34	testing	testing	NOUN
fnp-3049	239	35	adjustments	adjustment	NOUN
fnp-3049	239	36	,	,	PUNCT
fnp-3049	239	37	n	n	NOUN
fnp-3049	239	38	=	=	SYM
fnp-3049	239	39	8	8	NUM
fnp-3049	239	40	,	,	PUNCT
fnp-3049	239	41	sem	sem	NOUN
fnp-3049	239	42	)	)	PUNCT
fnp-3049	239	43	since	since	SCONJ
fnp-3049	239	44	our	our	PRON
fnp-3049	239	45	previous	previous	ADJ
fnp-3049	239	46	work	work	NOUN
fnp-3049	239	47	has	have	AUX
fnp-3049	239	48	shown	show	VERB
fnp-3049	239	49	that	that	SCONJ
fnp-3049	239	50	inhibiting	inhibit	VERB
fnp-3049	239	51	the	the	DET
fnp-3049	239	52	mpc	mpc	NOUN
fnp-3049	239	53	has	have	VERB
fnp-3049	239	54	strong	strong	ADJ
fnp-3049	239	55	anti	anti	ADJ
fnp-3049	239	56	-	-	ADJ
fnp-3049	239	57	inflammatory	inflammatory	ADJ
fnp-3049	239	58	and	and	CCONJ
fnp-3049	239	59	metabolic	metabolic	NOUN
fnp-3049	239	60	effects	effect	NOUN
fnp-3049	239	61	,	,	PUNCT
fnp-3049	239	62	we	we	PRON
fnp-3049	239	63	further	far	ADV
fnp-3049	239	64	investigated	investigate	VERB
fnp-3049	239	65	if	if	SCONJ
fnp-3049	239	66	our	our	PRON
fnp-3049	239	67	αsyn	αsyn	ADJ
fnp-3049	239	68	viral	viral	ADJ
fnp-3049	239	69	vector	vector	NOUN
fnp-3049	239	70	model	model	NOUN
fnp-3049	239	71	was	be	AUX
fnp-3049	239	72	lacking	lack	VERB
fnp-3049	239	73	these	these	DET
fnp-3049	239	74	features	feature	NOUN
fnp-3049	239	75	,	,	PUNCT
fnp-3049	239	76	which	which	PRON
fnp-3049	239	77	could	could	AUX
fnp-3049	239	78	explain	explain	VERB
fnp-3049	239	79	the	the	DET
fnp-3049	239	80	absence	absence	NOUN
fnp-3049	239	81	of	of	ADP
fnp-3049	239	82	any	any	DET
fnp-3049	239	83	apparent	apparent	ADJ
fnp-3049	239	84	therapeutic	therapeutic	ADJ
fnp-3049	239	85	benefits	benefit	NOUN
fnp-3049	239	86	.	.	PUNCT
fnp-3049	240	1	we	we	PRON
fnp-3049	240	2	examined	examine	VERB
fnp-3049	240	3	changes	change	NOUN
fnp-3049	240	4	in	in	ADP
fnp-3049	240	5	microglial	microglial	ADJ
fnp-3049	240	6	and	and	CCONJ
fnp-3049	240	7	lysosomal	lysosomal	ADJ
fnp-3049	240	8	markers	marker	NOUN
fnp-3049	240	9	at	at	ADP
fnp-3049	240	10	the	the	DET
fnp-3049	240	11	four	four	NUM
fnp-3049	240	12	-	-	PUNCT
fnp-3049	240	13	month	month	NOUN
fnp-3049	240	14	timepoint	timepoint	NOUN
fnp-3049	240	15	and	and	CCONJ
fnp-3049	240	16	found	find	VERB
fnp-3049	240	17	no	no	DET
fnp-3049	240	18	changes	change	NOUN
fnp-3049	240	19	in	in	ADP
fnp-3049	240	20	microglial	microglial	ADJ
fnp-3049	240	21	activation	activation	NOUN
fnp-3049	240	22	(	(	PUNCT
fnp-3049	240	23	fig	fig	NOUN
fnp-3049	240	24	.	.	PUNCT
fnp-3049	241	1	5a	5a	NUM
fnp-3049	241	2	-	-	PUNCT
fnp-3049	241	3	b	b	PROPN
fnp-3049	241	4	,	,	PUNCT
fnp-3049	241	5	e	e	NOUN
fnp-3049	241	6	)	)	PUNCT
fnp-3049	241	7	and	and	CCONJ
fnp-3049	241	8	no	no	DET
fnp-3049	241	9	changes	change	NOUN
fnp-3049	241	10	in	in	ADP
fnp-3049	241	11	markers	marker	NOUN
fnp-3049	241	12	of	of	ADP
fnp-3049	241	13	autophagy	autophagy	NOUN
fnp-3049	241	14	(	(	PUNCT
fnp-3049	241	15	lamp1	lamp1	NOUN
fnp-3049	241	16	and	and	CCONJ
fnp-3049	241	17	cathepsin	cathepsin	NOUN
fnp-3049	241	18	d	d	PROPN
fnp-3049	241	19	)	)	PUNCT
fnp-3049	241	20	in	in	ADP
fnp-3049	241	21	any	any	PRON
fnp-3049	241	22	of	of	ADP
fnp-3049	241	23	the	the	DET
fnp-3049	241	24	groups	group	NOUN
fnp-3049	241	25	examined	examine	VERB
fnp-3049	241	26	(	(	PUNCT
fnp-3049	241	27	fig	fig	NOUN
fnp-3049	241	28	.	.	PUNCT
fnp-3049	241	29	5c	5c	NUM
fnp-3049	241	30	,	,	PUNCT
fnp-3049	241	31	f	f	X
fnp-3049	241	32	-	-	PUNCT
fnp-3049	241	33	g	g	NOUN
fnp-3049	241	34	)	)	PUNCT
fnp-3049	241	35	.	.	PUNCT
fnp-3049	242	1	taken	take	VERB
fnp-3049	242	2	together	together	ADV
fnp-3049	242	3	,	,	PUNCT
fnp-3049	242	4	in	in	ADP
fnp-3049	242	5	absence	absence	NOUN
fnp-3049	242	6	of	of	ADP
fnp-3049	242	7	metabolic	metabolic	NOUN
fnp-3049	242	8	or	or	CCONJ
fnp-3049	242	9	lysosomal	lysosomal	ADJ
fnp-3049	242	10	deficits	deficit	NOUN
fnp-3049	242	11	and	and	CCONJ
fnp-3049	242	12	microglial	microglial	ADJ
fnp-3049	242	13	changes	change	NOUN
fnp-3049	242	14	(	(	PUNCT
fnp-3049	242	15	at	at	ADP
fnp-3049	242	16	least	least	ADJ
fnp-3049	242	17	at	at	ADP
fnp-3049	242	18	these	these	DET
fnp-3049	242	19	later	later	ADJ
fnp-3049	242	20	time	time	NOUN
fnp-3049	242	21	points	point	NOUN
fnp-3049	242	22	)	)	PUNCT
fnp-3049	242	23	,	,	PUNCT
fnp-3049	242	24	a	a	DET
fnp-3049	242	25	metabolic	metabolic	NOUN
fnp-3049	242	26	switch	switch	NOUN
fnp-3049	242	27	,	,	PUNCT
fnp-3049	242	28	by	by	ADP
fnp-3049	242	29	inhibiting	inhibit	VERB
fnp-3049	242	30	the	the	DET
fnp-3049	242	31	mpc	mpc	NOUN
fnp-3049	242	32	,	,	PUNCT
fnp-3049	242	33	does	do	AUX
fnp-3049	242	34	not	not	PART
fnp-3049	242	35	have	have	VERB
fnp-3049	242	36	a	a	DET
fnp-3049	242	37	beneficial	beneficial	ADJ
fnp-3049	242	38	effect	effect	NOUN
fnp-3049	242	39	on	on	ADP
fnp-3049	242	40	αsyn	αsyn	ADJ
fnp-3049	242	41	aggregation	aggregation	NOUN
fnp-3049	242	42	.	.	PUNCT
fnp-3049	243	1	figure	figure	NOUN
fnp-3049	243	2	5	5	NUM
fnp-3049	243	3	.	.	PUNCT
fnp-3049	244	1	absence	absence	NOUN
fnp-3049	244	2	of	of	ADP
fnp-3049	244	3	inflammatory	inflammatory	ADJ
fnp-3049	244	4	or	or	CCONJ
fnp-3049	244	5	autophagy	autophagy	ADJ
fnp-3049	244	6	deficits	deficit	NOUN
fnp-3049	244	7	in	in	ADP
fnp-3049	244	8	αsyn	αsyn	NOUN
fnp-3049	244	9	overexpressing	overexpresse	VERB
fnp-3049	244	10	animals	animal	NOUN
fnp-3049	244	11	.	.	PUNCT
fnp-3049	245	1	a	a	X
fnp-3049	245	2	)	)	PUNCT
fnp-3049	245	3	overview	overview	NOUN
fnp-3049	245	4	of	of	ADP
fnp-3049	245	5	microglial	microglial	ADJ
fnp-3049	245	6	morphology	morphology	NOUN
fnp-3049	245	7	via	via	ADP
fnp-3049	245	8	iba-1	iba-1	PUNCT
fnp-3049	245	9	staining	stain	VERB
fnp-3049	245	10	in	in	ADP
fnp-3049	245	11	rat	rat	NOUN
fnp-3049	245	12	sn	sn	PROPN
fnp-3049	245	13	shows	show	VERB
fnp-3049	245	14	no	no	DET
fnp-3049	245	15	microglial	microglial	ADJ
fnp-3049	245	16	activation	activation	NOUN
fnp-3049	245	17	in	in	ADP
fnp-3049	245	18	αsyn	αsyn	NOUN
fnp-3049	245	19	overexpressing	overexpresse	VERB
fnp-3049	245	20	conditions	condition	NOUN
fnp-3049	245	21	.	.	PUNCT
fnp-3049	246	1	scale	scale	NOUN
fnp-3049	246	2	bar	bar	NOUN
fnp-3049	246	3	=	=	PUNCT
fnp-3049	246	4	50	50	NUM
fnp-3049	246	5	μm	μm	NOUN
fnp-3049	246	6	.	.	PUNCT
fnp-3049	247	1	b	b	X
fnp-3049	247	2	)	)	PUNCT
fnp-3049	247	3	quantification	quantification	NOUN
fnp-3049	247	4	of	of	ADP
fnp-3049	247	5	microglial	microglial	ADJ
fnp-3049	247	6	hydraulic	hydraulic	ADJ
fnp-3049	247	7	radius	radius	NOUN
fnp-3049	247	8	as	as	ADP
fnp-3049	247	9	a	a	DET
fnp-3049	247	10	measure	measure	NOUN
fnp-3049	247	11	of	of	ADP
fnp-3049	247	12	microglial	microglial	ADJ
fnp-3049	247	13	ramification	ramification	NOUN
fnp-3049	247	14	and	and	CCONJ
fnp-3049	247	15	activation	activation	NOUN
fnp-3049	247	16	(	(	PUNCT
fnp-3049	247	17	n	n	NOUN
fnp-3049	247	18	=	=	SYM
fnp-3049	247	19	8	8	NUM
fnp-3049	247	20	,	,	PUNCT
fnp-3049	247	21	sem	sem	NOUN
fnp-3049	247	22	)	)	PUNCT
fnp-3049	247	23	.	.	PUNCT
fnp-3049	248	1	c	c	X
fnp-3049	248	2	)	)	PUNCT
fnp-3049	248	3	representative	representative	ADJ
fnp-3049	248	4	western	western	ADJ
fnp-3049	248	5	blot	blot	NOUN
fnp-3049	248	6	images	image	NOUN
fnp-3049	248	7	of	of	ADP
fnp-3049	248	8	inflammatory	inflammatory	ADJ
fnp-3049	248	9	and	and	CCONJ
fnp-3049	248	10	autophagy	autophagy	ADJ
fnp-3049	248	11	markers	marker	NOUN
fnp-3049	248	12	in	in	ADP
fnp-3049	248	13	sn	sn	PROPN
fnp-3049	248	14	.	.	PUNCT
fnp-3049	249	1	d	d	X
fnp-3049	249	2	)	)	PUNCT
fnp-3049	249	3	iba-1	iba-1	PUNCT
fnp-3049	249	4	and	and	CCONJ
fnp-3049	249	5	e	e	X
fnp-3049	249	6	)	)	PUNCT
fnp-3049	249	7	gfap	gfap	ADJ
fnp-3049	249	8	markers	marker	NOUN
fnp-3049	249	9	show	show	VERB
fnp-3049	249	10	no	no	DET
fnp-3049	249	11	signs	sign	NOUN
fnp-3049	249	12	of	of	ADP
fnp-3049	249	13	inflammatory	inflammatory	ADJ
fnp-3049	249	14	activation	activation	NOUN
fnp-3049	249	15	(	(	PUNCT
fnp-3049	249	16	n	n	NOUN
fnp-3049	249	17	=	=	SYM
fnp-3049	249	18	6	6	NUM
fnp-3049	249	19	,	,	PUNCT
fnp-3049	249	20	sem	sem	NOUN
fnp-3049	249	21	)	)	PUNCT
fnp-3049	249	22	.	.	PUNCT
fnp-3049	250	1	d	d	X
fnp-3049	250	2	)	)	PUNCT
fnp-3049	250	3	cathepsin	cathepsin	NOUN
fnp-3049	250	4	-	-	PUNCT
fnp-3049	250	5	d	d	NOUN
fnp-3049	250	6	and	and	CCONJ
fnp-3049	250	7	e	e	NOUN
fnp-3049	250	8	)	)	PUNCT
fnp-3049	250	9	lamp1	lamp1	NOUN
fnp-3049	250	10	expression	expression	NOUN
fnp-3049	250	11	is	be	AUX
fnp-3049	250	12	unaltered	unaltere	VERB
fnp-3049	250	13	in	in	ADP
fnp-3049	250	14	αsyn	αsyn	NOUN
fnp-3049	250	15	overexpressing	overexpresse	VERB
fnp-3049	250	16	animals	animal	NOUN
fnp-3049	250	17	(	(	PUNCT
fnp-3049	250	18	n	n	NOUN
fnp-3049	250	19	=	=	SYM
fnp-3049	250	20	6	6	NUM
fnp-3049	250	21	,	,	PUNCT
fnp-3049	250	22	sem	sem	NOUN
fnp-3049	250	23	)	)	PUNCT
fnp-3049	250	24	.	.	PUNCT
fnp-3049	251	1	inhibiting	inhibit	VERB
fnp-3049	251	2	the	the	DET
fnp-3049	251	3	mpc	mpc	NOUN
fnp-3049	251	4	in	in	ADP
fnp-3049	251	5	a	a	DET
fnp-3049	251	6	mouse	mouse	NOUN
fnp-3049	251	7	pff	pff	NOUN
fnp-3049	251	8	seeding	seeding	NOUN
fnp-3049	251	9	model	model	NOUN
fnp-3049	251	10	next	next	ADV
fnp-3049	251	11	,	,	PUNCT
fnp-3049	251	12	to	to	PART
fnp-3049	251	13	investigate	investigate	VERB
fnp-3049	251	14	the	the	DET
fnp-3049	251	15	effects	effect	NOUN
fnp-3049	251	16	of	of	ADP
fnp-3049	251	17	inhibiting	inhibit	VERB
fnp-3049	251	18	mpc	mpc	NOUN
fnp-3049	251	19	on	on	ADP
fnp-3049	251	20	αsyn	αsyn	PROPN
fnp-3049	251	21	aggregation	aggregation	NOUN
fnp-3049	251	22	,	,	PUNCT
fnp-3049	251	23	we	we	PRON
fnp-3049	251	24	examined	examine	VERB
fnp-3049	251	25	the	the	DET
fnp-3049	251	26	effects	effect	NOUN
fnp-3049	251	27	of	of	ADP
fnp-3049	251	28	msdc-0160	msdc-0160	NOUN
fnp-3049	251	29	on	on	ADP
fnp-3049	251	30	αsyn	αsyn	ADJ
fnp-3049	251	31	propagation	propagation	NOUN
fnp-3049	251	32	.	.	PUNCT
fnp-3049	252	1	we	we	PRON
fnp-3049	252	2	used	use	VERB
fnp-3049	252	3	a	a	DET
fnp-3049	252	4	previously	previously	ADV
fnp-3049	252	5	established	establish	VERB
fnp-3049	252	6	seeding	seeding	NOUN
fnp-3049	252	7	model	model	NOUN
fnp-3049	252	8	where	where	SCONJ
fnp-3049	252	9	αsyn	αsyn	ADJ
fnp-3049	252	10	pffs	pff	NOUN
fnp-3049	252	11	are	be	AUX
fnp-3049	252	12	unilaterally	unilaterally	ADV
fnp-3049	252	13	injected	inject	VERB
fnp-3049	252	14	into	into	ADP
fnp-3049	252	15	the	the	DET
fnp-3049	252	16	ob	ob	NOUN
fnp-3049	252	17	of	of	ADP
fnp-3049	252	18	12	12	NUM
fnp-3049	252	19	-	-	PUNCT
fnp-3049	252	20	week	week	NOUN
fnp-3049	252	21	-	-	PUNCT
fnp-3049	252	22	old	old	ADJ
fnp-3049	252	23	wild	wild	ADJ
fnp-3049	252	24	type	type	NOUN
fnp-3049	252	25	mice	mouse	NOUN
fnp-3049	252	26	.	.	PUNCT
fnp-3049	253	1	over	over	ADP
fnp-3049	253	2	time	time	NOUN
fnp-3049	253	3	,	,	PUNCT
fnp-3049	253	4	αsyn	αsyn	ADJ
fnp-3049	253	5	pathology	pathology	NOUN
fnp-3049	253	6	will	will	AUX
fnp-3049	253	7	propagate	propagate	VERB
fnp-3049	253	8	via	via	ADP
fnp-3049	253	9	intraneuronal	intraneuronal	ADJ
fnp-3049	253	10	connections	connection	NOUN
fnp-3049	253	11	and	and	CCONJ
fnp-3049	253	12	cause	cause	VERB
fnp-3049	253	13	pathology	pathology	NOUN
fnp-3049	253	14	in	in	ADP
fnp-3049	253	15	upstream	upstream	ADJ
fnp-3049	253	16	regions19,20	regions19,20	ADJ
fnp-3049	253	17	.	.	PUNCT
fnp-3049	254	1	one	one	NUM
fnp-3049	254	2	-	-	PUNCT
fnp-3049	254	3	week	week	NOUN
fnp-3049	254	4	post	post	NOUN
fnp-3049	254	5	pff	pff	PROPN
fnp-3049	254	6	or	or	CCONJ
fnp-3049	254	7	pbs	pbs	PROPN
fnp-3049	254	8	injection	injection	NOUN
fnp-3049	254	9	into	into	ADP
fnp-3049	254	10	the	the	DET
fnp-3049	254	11	ob	ob	NOUN
fnp-3049	254	12	,	,	PUNCT
fnp-3049	254	13	the	the	DET
fnp-3049	254	14	mice	mouse	NOUN
fnp-3049	254	15	were	be	AUX
fnp-3049	254	16	allowed	allow	VERB
fnp-3049	254	17	free	free	ADJ
fnp-3049	254	18	access	access	NOUN
fnp-3049	254	19	to	to	ADP
fnp-3049	254	20	chow	chow	PROPN
fnp-3049	254	21	containing	contain	VERB
fnp-3049	254	22	either	either	CCONJ
fnp-3049	254	23	msdc-0160	msdc-0160	ADJ
fnp-3049	254	24	or	or	CCONJ
fnp-3049	254	25	placebo	placebo	NOUN
fnp-3049	254	26	(	(	PUNCT
fnp-3049	254	27	fig	fig	NOUN
fnp-3049	254	28	.	.	PUNCT
fnp-3049	255	1	6a	6a	NOUN
fnp-3049	255	2	)	)	PUNCT
fnp-3049	255	3	.	.	PUNCT
fnp-3049	256	1	during	during	ADP
fnp-3049	256	2	the	the	DET
fnp-3049	256	3	time	time	NOUN
fnp-3049	256	4	of	of	ADP
fnp-3049	256	5	chow	chow	PROPN
fnp-3049	256	6	administration	administration	NOUN
fnp-3049	256	7	,	,	PUNCT
fnp-3049	256	8	we	we	PRON
fnp-3049	256	9	did	do	AUX
fnp-3049	256	10	not	not	PART
fnp-3049	256	11	observe	observe	VERB
fnp-3049	256	12	any	any	DET
fnp-3049	256	13	differences	difference	NOUN
fnp-3049	256	14	in	in	ADP
fnp-3049	256	15	animal	animal	NOUN
fnp-3049	256	16	body	body	NOUN
fnp-3049	256	17	weight	weight	NOUN
fnp-3049	256	18	or	or	CCONJ
fnp-3049	256	19	chow	chow	NOUN
fnp-3049	256	20	consumption	consumption	NOUN
fnp-3049	256	21	between	between	ADP
fnp-3049	256	22	groups	group	NOUN
fnp-3049	256	23	(	(	PUNCT
fnp-3049	256	24	supplementary	supplementary	ADJ
fnp-3049	256	25	fig	fig	NOUN
fnp-3049	256	26	.	.	PUNCT
fnp-3049	257	1	5a	5a	NUM
fnp-3049	257	2	,	,	PUNCT
fnp-3049	257	3	b	b	NOUN
fnp-3049	257	4	)	)	PUNCT
fnp-3049	257	5	.	.	PUNCT
fnp-3049	258	1	at	at	ADP
fnp-3049	258	2	5and	5and	NUM
fnp-3049	258	3	13	13	NUM
fnp-3049	258	4	-	-	PUNCT
fnp-3049	258	5	weeks	week	NOUN
fnp-3049	258	6	post	post	ADJ
fnp-3049	258	7	-	-	ADJ
fnp-3049	258	8	surgery	surgery	ADJ
fnp-3049	258	9	,	,	PUNCT
fnp-3049	258	10	plasma	plasma	NOUN
fnp-3049	258	11	was	be	AUX
fnp-3049	258	12	collected	collect	VERB
fnp-3049	258	13	and	and	CCONJ
fnp-3049	258	14	the	the	DET
fnp-3049	258	15	presence	presence	NOUN
fnp-3049	258	16	of	of	ADP
fnp-3049	258	17	hydroxymitoglitazone	hydroxymitoglitazone	NOUN
fnp-3049	258	18	(	(	PUNCT
fnp-3049	258	19	msdc-0160	msdc-0160	ADJ
fnp-3049	258	20	metabolite	metabolite	NOUN
fnp-3049	258	21	)	)	PUNCT
fnp-3049	258	22	was	be	AUX
fnp-3049	258	23	quantified	quantify	VERB
fnp-3049	258	24	(	(	PUNCT
fnp-3049	258	25	supplementary	supplementary	ADJ
fnp-3049	258	26	fig	fig	NOUN
fnp-3049	258	27	.	.	PUNCT
fnp-3049	258	28	5c	5c	NUM
fnp-3049	258	29	)	)	PUNCT
fnp-3049	258	30	,	,	PUNCT
fnp-3049	258	31	showing	show	VERB
fnp-3049	258	32	detectable	detectable	ADJ
fnp-3049	258	33	levels	level	NOUN
fnp-3049	258	34	of	of	ADP
fnp-3049	258	35	the	the	DET
fnp-3049	258	36	metabolite	metabolite	NOUN
fnp-3049	258	37	in	in	ADP
fnp-3049	258	38	treated	treat	VERB
fnp-3049	258	39	groups	group	NOUN
fnp-3049	258	40	.	.	PUNCT
fnp-3049	259	1	figure	figure	VERB
fnp-3049	259	2	6	6	NUM
fnp-3049	259	3	.	.	PUNCT
fnp-3049	260	1	a	a	DET
fnp-3049	260	2	metabolic	metabolic	NOUN
fnp-3049	260	3	switch	switch	NOUN
fnp-3049	260	4	increases	increase	VERB
fnp-3049	260	5	αsyn	αsyn	ADJ
fnp-3049	260	6	pathology	pathology	NOUN
fnp-3049	260	7	load	load	NOUN
fnp-3049	260	8	and	and	CCONJ
fnp-3049	260	9	propagation	propagation	NOUN
fnp-3049	260	10	in	in	ADP
fnp-3049	260	11	mouse	mouse	PROPN
fnp-3049	260	12	aon	aon	PROPN
fnp-3049	260	13	and	and	CCONJ
fnp-3049	260	14	prh	prh	PROPN
fnp-3049	260	15	.	.	PUNCT
fnp-3049	261	1	a	a	DET
fnp-3049	261	2	)	)	PUNCT
fnp-3049	261	3	experimental	experimental	ADJ
fnp-3049	261	4	timeline	timeline	NOUN
fnp-3049	261	5	;	;	PUNCT
fnp-3049	261	6	at	at	ADP
fnp-3049	261	7	12	12	NUM
fnp-3049	261	8	weeks	week	NOUN
fnp-3049	261	9	of	of	ADP
fnp-3049	261	10	age	age	NOUN
fnp-3049	261	11	c57bl/6j	c57bl/6j	NOUN
fnp-3049	261	12	mice	mouse	NOUN
fnp-3049	261	13	were	be	AUX
fnp-3049	261	14	injected	inject	VERB
fnp-3049	261	15	with	with	ADP
fnp-3049	261	16	pffs	pff	NOUN
fnp-3049	261	17	or	or	CCONJ
fnp-3049	261	18	pbs	pbs	PROPN
fnp-3049	261	19	and	and	CCONJ
fnp-3049	261	20	starting	start	VERB
fnp-3049	261	21	at	at	ADP
fnp-3049	261	22	one	one	NUM
fnp-3049	261	23	-	-	PUNCT
fnp-3049	261	24	week	week	NOUN
fnp-3049	261	25	post	post	NOUN
fnp-3049	261	26	-	-	NOUN
fnp-3049	261	27	surgery	surgery	NOUN
fnp-3049	261	28	they	they	PRON
fnp-3049	261	29	had	have	VERB
fnp-3049	261	30	free	free	ADJ
fnp-3049	261	31	access	access	NOUN
fnp-3049	261	32	to	to	ADP
fnp-3049	261	33	msdc-0160	msdc-0160	ADJ
fnp-3049	261	34	or	or	CCONJ
fnp-3049	261	35	placebo	placebo	NOUN
fnp-3049	261	36	containing	contain	VERB
fnp-3049	261	37	chow	chow	NOUN
fnp-3049	261	38	until	until	ADP
fnp-3049	261	39	the	the	DET
fnp-3049	261	40	5or	5or	ADJ
fnp-3049	261	41	13	13	NUM
fnp-3049	261	42	-	-	PUNCT
fnp-3049	261	43	week	week	NOUN
fnp-3049	261	44	endpoint	endpoint	NOUN
fnp-3049	261	45	.	.	PUNCT
fnp-3049	262	1	quantification	quantification	NOUN
fnp-3049	262	2	of	of	ADP
fnp-3049	262	3	αsyn	αsyn	ADJ
fnp-3049	262	4	pser129	pser129	PROPN
fnp-3049	262	5	positive	positive	ADJ
fnp-3049	262	6	signal	signal	NOUN
fnp-3049	262	7	in	in	ADP
fnp-3049	262	8	b	b	NOUN
fnp-3049	262	9	)	)	PUNCT
fnp-3049	262	10	the	the	DET
fnp-3049	262	11	aon	aon	PROPN
fnp-3049	262	12	and	and	CCONJ
fnp-3049	262	13	c	c	X
fnp-3049	262	14	)	)	PUNCT
fnp-3049	262	15	the	the	DET
fnp-3049	262	16	prh	prh	NOUN
fnp-3049	262	17	after	after	ADP
fnp-3049	262	18	5	5	NUM
fnp-3049	262	19	or	or	CCONJ
fnp-3049	262	20	13	13	NUM
fnp-3049	262	21	weeks	week	NOUN
fnp-3049	262	22	of	of	ADP
fnp-3049	262	23	msdc-0160	msdc-0160	ADJ
fnp-3049	262	24	or	or	CCONJ
fnp-3049	262	25	placebo	placebo	NOUN
fnp-3049	262	26	treatment	treatment	NOUN
fnp-3049	262	27	.	.	PUNCT
fnp-3049	263	1	msdc-0160	msdc-0160	ADJ
fnp-3049	263	2	treated	treat	VERB
fnp-3049	263	3	mice	mouse	NOUN
fnp-3049	263	4	had	have	VERB
fnp-3049	263	5	significantly	significantly	ADV
fnp-3049	263	6	more	more	ADJ
fnp-3049	263	7	αsyn	αsyn	ADJ
fnp-3049	263	8	pser129	pser129	PROPN
fnp-3049	263	9	positive	positive	ADJ
fnp-3049	263	10	stain	stain	NOUN
fnp-3049	263	11	at	at	ADP
fnp-3049	263	12	5	5	NUM
fnp-3049	263	13	weeks	week	NOUN
fnp-3049	263	14	post	post	ADJ
fnp-3049	263	15	-	-	NOUN
fnp-3049	263	16	surgery	surgery	NOUN
fnp-3049	263	17	than	than	ADP
fnp-3049	263	18	the	the	DET
fnp-3049	263	19	placebo	placebo	NOUN
fnp-3049	263	20	group	group	NOUN
fnp-3049	263	21	(	(	PUNCT
fnp-3049	263	22	1.8	1.8	NUM
fnp-3049	263	23	times	time	NOUN
fnp-3049	263	24	more	more	ADJ
fnp-3049	263	25	;	;	PUNCT
fnp-3049	263	26	p=0.02	p=0.02	NOUN
fnp-3049	263	27	,	,	PUNCT
fnp-3049	263	28	95	95	NUM
fnp-3049	263	29	%	%	NOUN
fnp-3049	263	30	ci	ci	NOUN
fnp-3049	263	31	1.176	1.176	NUM
fnp-3049	263	32	2.824	2.824	NUM
fnp-3049	263	33	,	,	PUNCT
fnp-3049	263	34	beta	beta	ADJ
fnp-3049	263	35	mixed	mix	VERB
fnp-3049	263	36	-	-	PUNCT
fnp-3049	263	37	effects	effect	NOUN
fnp-3049	263	38	regression	regression	NOUN
fnp-3049	263	39	)	)	PUNCT
fnp-3049	263	40	.	.	PUNCT
fnp-3049	264	1	there	there	PRON
fnp-3049	264	2	is	be	VERB
fnp-3049	264	3	also	also	ADV
fnp-3049	264	4	weak	weak	ADJ
fnp-3049	264	5	evidence	evidence	NOUN
fnp-3049	264	6	that	that	SCONJ
fnp-3049	264	7	this	this	PRON
fnp-3049	264	8	persists	persist	VERB
fnp-3049	264	9	at	at	ADP
fnp-3049	264	10	the	the	DET
fnp-3049	264	11	13	13	NUM
fnp-3049	264	12	-	-	PUNCT
fnp-3049	264	13	week	week	NOUN
fnp-3049	264	14	timepoint	timepoint	NOUN
fnp-3049	264	15	(	(	PUNCT
fnp-3049	264	16	p=0.085	p=0.085	NOUN
fnp-3049	264	17	,	,	PUNCT
fnp-3049	264	18	95	95	NUM
fnp-3049	264	19	%	%	NOUN
fnp-3049	264	20	ci	ci	NOUN
fnp-3049	264	21	0.986	0.986	NUM
fnp-3049	264	22	-	-	SYM
fnp-3049	264	23	1.92	1.92	NUM
fnp-3049	264	24	,	,	PUNCT
fnp-3049	264	25	beta	beta	ADJ
fnp-3049	264	26	mixed	mix	VERB
fnp-3049	264	27	-	-	PUNCT
fnp-3049	264	28	effects	effect	NOUN
fnp-3049	264	29	regression	regression	NOUN
fnp-3049	264	30	)	)	PUNCT
fnp-3049	264	31	.	.	PUNCT
fnp-3049	265	1	c	c	X
fnp-3049	265	2	)	)	PUNCT
fnp-3049	265	3	quantification	quantification	NOUN
fnp-3049	265	4	of	of	ADP
fnp-3049	265	5	αsyn	αsyn	ADJ
fnp-3049	265	6	pser129	pser129	PROPN
fnp-3049	265	7	positive	positive	ADJ
fnp-3049	265	8	signal	signal	NOUN
fnp-3049	265	9	in	in	ADP
fnp-3049	265	10	the	the	DET
fnp-3049	265	11	prh	prh	NOUN
fnp-3049	265	12	after	after	ADP
fnp-3049	265	13	one	one	NUM
fnp-3049	265	14	and	and	CCONJ
fnp-3049	265	15	three	three	NUM
fnp-3049	265	16	months	month	NOUN
fnp-3049	265	17	of	of	ADP
fnp-3049	265	18	msdc-0160	msdc-0160	ADJ
fnp-3049	265	19	or	or	CCONJ
fnp-3049	265	20	placebo	placebo	NOUN
fnp-3049	265	21	treatment	treatment	NOUN
fnp-3049	265	22	.	.	PUNCT
fnp-3049	266	1	d	d	X
fnp-3049	266	2	)	)	PUNCT
fnp-3049	266	3	representative	representative	ADJ
fnp-3049	266	4	images	image	NOUN
fnp-3049	266	5	of	of	ADP
fnp-3049	266	6	αsyn	αsyn	NOUN
fnp-3049	266	7	pser129	pser129	PROPN
fnp-3049	266	8	staining	stain	VERB
fnp-3049	266	9	in	in	ADP
fnp-3049	266	10	d	d	PROPN
fnp-3049	266	11	)	)	PUNCT
fnp-3049	266	12	the	the	DET
fnp-3049	266	13	ipsilateral	ipsilateral	ADJ
fnp-3049	266	14	aon	aon	PROPN
fnp-3049	266	15	(	(	PUNCT
fnp-3049	266	16	scalebar	scalebar	NOUN
fnp-3049	266	17	=	=	NOUN
fnp-3049	266	18	130	130	NUM
fnp-3049	266	19	μm	μm	NUM
fnp-3049	266	20	)	)	PUNCT
fnp-3049	266	21	and	and	CCONJ
fnp-3049	266	22	e	e	X
fnp-3049	266	23	)	)	PUNCT
fnp-3049	266	24	the	the	DET
fnp-3049	266	25	prh	prh	NOUN
fnp-3049	266	26	(	(	PUNCT
fnp-3049	266	27	scalebar	scalebar	NOUN
fnp-3049	266	28	=	=	NOUN
fnp-3049	266	29	100	100	NUM
fnp-3049	266	30	μm	μm	NUM
fnp-3049	266	31	)	)	PUNCT
fnp-3049	266	32	.	.	PUNCT
fnp-3049	267	1	unilateral	unilateral	ADJ
fnp-3049	267	2	pff	pff	PROPN
fnp-3049	267	3	injections	injection	NOUN
fnp-3049	267	4	have	have	AUX
fnp-3049	267	5	previously	previously	ADV
fnp-3049	267	6	been	be	AUX
fnp-3049	267	7	shown	show	VERB
fnp-3049	267	8	to	to	PART
fnp-3049	267	9	impair	impair	VERB
fnp-3049	267	10	olfactory	olfactory	ADJ
fnp-3049	267	11	function	function	NOUN
fnp-3049	267	12	in	in	ADP
fnp-3049	267	13	mice20	mice20	PROPN
fnp-3049	267	14	.	.	PUNCT
fnp-3049	268	1	olfactory	olfactory	ADJ
fnp-3049	268	2	function	function	NOUN
fnp-3049	268	3	was	be	AUX
fnp-3049	268	4	thus	thus	ADV
fnp-3049	268	5	examined	examine	VERB
fnp-3049	268	6	13	13	NUM
fnp-3049	268	7	weeks	week	NOUN
fnp-3049	268	8	post	post	ADJ
fnp-3049	268	9	-	-	ADJ
fnp-3049	268	10	surgery	surgery	NOUN
fnp-3049	268	11	using	use	VERB
fnp-3049	268	12	the	the	DET
fnp-3049	268	13	buried	bury	VERB
fnp-3049	268	14	pellet	pellet	NOUN
fnp-3049	268	15	test	test	NOUN
fnp-3049	268	16	.	.	PUNCT
fnp-3049	269	1	no	no	DET
fnp-3049	269	2	significant	significant	ADJ
fnp-3049	269	3	difference	difference	NOUN
fnp-3049	269	4	was	be	AUX
fnp-3049	269	5	observed	observe	VERB
fnp-3049	269	6	between	between	ADP
fnp-3049	269	7	the	the	DET
fnp-3049	269	8	pbs	pbs	PROPN
fnp-3049	269	9	and	and	CCONJ
fnp-3049	269	10	pff	pff	PROPN
fnp-3049	269	11	groups	group	NOUN
fnp-3049	269	12	,	,	PUNCT
fnp-3049	269	13	regardless	regardless	ADV
fnp-3049	269	14	of	of	ADP
fnp-3049	269	15	whether	whether	SCONJ
fnp-3049	269	16	the	the	DET
fnp-3049	269	17	mice	mouse	NOUN
fnp-3049	269	18	had	have	AUX
fnp-3049	269	19	been	be	AUX
fnp-3049	269	20	treated	treat	VERB
fnp-3049	269	21	with	with	ADP
fnp-3049	269	22	placebo	placebo	NOUN
fnp-3049	269	23	or	or	CCONJ
fnp-3049	269	24	msdc-0160	msdc-0160	ADJ
fnp-3049	269	25	(	(	PUNCT
fnp-3049	269	26	supplementary	supplementary	ADJ
fnp-3049	269	27	fig	fig	NOUN
fnp-3049	269	28	.	.	PUNCT
fnp-3049	270	1	6a	6a	NOUN
fnp-3049	270	2	)	)	PUNCT
fnp-3049	270	3	.	.	PUNCT
fnp-3049	271	1	when	when	SCONJ
fnp-3049	271	2	assessing	assess	VERB
fnp-3049	271	3	the	the	DET
fnp-3049	271	4	total	total	ADJ
fnp-3049	271	5	number	number	NOUN
fnp-3049	271	6	of	of	ADP
fnp-3049	271	7	neun	neun	NOUN
fnp-3049	271	8	and	and	CCONJ
fnp-3049	271	9	cv	cv	ADJ
fnp-3049	271	10	-	-	ADJ
fnp-3049	271	11	positive	positive	ADJ
fnp-3049	271	12	cells	cell	NOUN
fnp-3049	271	13	in	in	ADP
fnp-3049	271	14	the	the	DET
fnp-3049	271	15	aon	aon	PROPN
fnp-3049	271	16	13	13	NUM
fnp-3049	271	17	weeks	week	NOUN
fnp-3049	271	18	post	post	ADJ
fnp-3049	271	19	-	-	NOUN
fnp-3049	271	20	surgery	surgery	NOUN
fnp-3049	271	21	via	via	ADP
fnp-3049	271	22	stereological	stereological	ADJ
fnp-3049	271	23	quantification	quantification	NOUN
fnp-3049	271	24	,	,	PUNCT
fnp-3049	271	25	we	we	PRON
fnp-3049	271	26	found	find	VERB
fnp-3049	271	27	no	no	DET
fnp-3049	271	28	significant	significant	ADJ
fnp-3049	271	29	differences	difference	NOUN
fnp-3049	271	30	between	between	ADP
fnp-3049	271	31	any	any	PRON
fnp-3049	271	32	of	of	ADP
fnp-3049	271	33	the	the	DET
fnp-3049	271	34	experimental	experimental	ADJ
fnp-3049	271	35	groups	group	NOUN
fnp-3049	271	36	(	(	PUNCT
fnp-3049	271	37	supplementary	supplementary	ADJ
fnp-3049	271	38	fig	fig	NOUN
fnp-3049	271	39	.	.	PUNCT
fnp-3049	272	1	6b	6b	PROPN
fnp-3049	272	2	&	&	CCONJ
fnp-3049	272	3	c	c	NOUN
fnp-3049	272	4	)	)	PUNCT
fnp-3049	272	5	.	.	PUNCT
fnp-3049	273	1	immunohistological	immunohistological	ADJ
fnp-3049	273	2	assessment	assessment	NOUN
fnp-3049	273	3	at	at	ADP
fnp-3049	273	4	5and	5and	NUM
fnp-3049	273	5	13	13	NUM
fnp-3049	273	6	-	-	PUNCT
fnp-3049	273	7	weeks	week	NOUN
fnp-3049	273	8	post	post	ADJ
fnp-3049	273	9	-	-	ADJ
fnp-3049	273	10	surgery	surgery	NOUN
fnp-3049	273	11	revealed	reveal	VERB
fnp-3049	273	12	a	a	DET
fnp-3049	273	13	significantly	significantly	ADV
fnp-3049	273	14	higher	high	ADJ
fnp-3049	273	15	percentage	percentage	NOUN
fnp-3049	273	16	area	area	NOUN
fnp-3049	273	17	containing	contain	VERB
fnp-3049	273	18	pathological	pathological	ADJ
fnp-3049	273	19	αsyn	αsyn	NOUN
fnp-3049	273	20	(	(	PUNCT
fnp-3049	273	21	αsyn	αsyn	PROPN
fnp-3049	273	22	pser129	pser129	PROPN
fnp-3049	273	23	)	)	PUNCT
fnp-3049	273	24	in	in	ADP
fnp-3049	273	25	the	the	DET
fnp-3049	273	26	aon	aon	PROPN
fnp-3049	273	27	than	than	ADP
fnp-3049	273	28	the	the	DET
fnp-3049	273	29	prh	prh	NOUN
fnp-3049	273	30	,	,	PUNCT
fnp-3049	273	31	regardless	regardless	ADV
fnp-3049	273	32	of	of	ADP
fnp-3049	273	33	time	time	NOUN
fnp-3049	273	34	point	point	NOUN
fnp-3049	273	35	and	and	CCONJ
fnp-3049	273	36	treatment	treatment	NOUN
fnp-3049	273	37	group	group	NOUN
fnp-3049	273	38	(	(	PUNCT
fnp-3049	273	39	8.5	8.5	NUM
fnp-3049	273	40	-	-	SYM
fnp-3049	273	41	16	16	NUM
fnp-3049	273	42	times	time	NOUN
fnp-3049	273	43	higher	high	ADJ
fnp-3049	273	44	;	;	PUNCT
fnp-3049	273	45	all	all	DET
fnp-3049	273	46	p	p	NOUN
fnp-3049	273	47	≤	≤	NUM
fnp-3049	273	48	0.001	0.001	NUM
fnp-3049	273	49	)	)	PUNCT
fnp-3049	273	50	(	(	PUNCT
fnp-3049	273	51	fig	fig	NOUN
fnp-3049	273	52	.	.	PUNCT
fnp-3049	274	1	6b	6b	NOUN
fnp-3049	274	2	-	-	PUNCT
fnp-3049	274	3	e	e	NOUN
fnp-3049	274	4	)	)	PUNCT
fnp-3049	274	5	.	.	PUNCT
fnp-3049	275	1	the	the	DET
fnp-3049	275	2	same	same	ADJ
fnp-3049	275	3	was	be	AUX
fnp-3049	275	4	seen	see	VERB
fnp-3049	275	5	for	for	ADP
fnp-3049	275	6	the	the	DET
fnp-3049	275	7	ipsilateral	ipsilateral	ADJ
fnp-3049	275	8	side	side	NOUN
fnp-3049	275	9	compared	compare	VERB
fnp-3049	275	10	to	to	ADP
fnp-3049	275	11	the	the	DET
fnp-3049	275	12	contralateral	contralateral	ADJ
fnp-3049	275	13	side	side	NOUN
fnp-3049	275	14	(	(	PUNCT
fnp-3049	275	15	65	65	NUM
fnp-3049	275	16	-	-	SYM
fnp-3049	275	17	78	78	NUM
fnp-3049	275	18	%	%	NOUN
fnp-3049	275	19	less	less	ADJ
fnp-3049	275	20	on	on	ADP
fnp-3049	275	21	the	the	DET
fnp-3049	275	22	contralateral	contralateral	ADJ
fnp-3049	275	23	side	side	NOUN
fnp-3049	275	24	;	;	PUNCT
fnp-3049	275	25	p	p	PROPN
fnp-3049	275	26	≤	≤	NOUN
fnp-3049	275	27	0.001	0.001	NUM
fnp-3049	275	28	)	)	PUNCT
fnp-3049	275	29	.	.	PUNCT
fnp-3049	276	1	from	from	ADP
fnp-3049	276	2	5	5	NUM
fnp-3049	276	3	to	to	PART
fnp-3049	276	4	13	13	NUM
fnp-3049	276	5	weeks	week	NOUN
fnp-3049	276	6	post	post	ADJ
fnp-3049	276	7	-	-	ADJ
fnp-3049	276	8	surgery	surgery	ADJ
fnp-3049	276	9	,	,	PUNCT
fnp-3049	276	10	αsyn	αsyn	PROPN
fnp-3049	276	11	pser129	pser129	PROPN
fnp-3049	276	12	increased	increase	VERB
fnp-3049	276	13	significantly	significantly	ADV
fnp-3049	276	14	for	for	ADP
fnp-3049	276	15	msdc-0160	msdc-0160	ADJ
fnp-3049	276	16	and	and	CCONJ
fnp-3049	276	17	placebo	placebo	NOUN
fnp-3049	276	18	treated	treat	VERB
fnp-3049	276	19	animals	animal	NOUN
fnp-3049	276	20	,	,	PUNCT
fnp-3049	276	21	which	which	PRON
fnp-3049	276	22	both	both	PRON
fnp-3049	276	23	gained	gain	VERB
fnp-3049	276	24	~99.2	~99.2	NOUN
fnp-3049	276	25	%	%	NOUN
fnp-3049	276	26	and	and	CCONJ
fnp-3049	276	27	163.2	163.2	NUM
fnp-3049	276	28	%	%	NOUN
fnp-3049	276	29	of	of	ADP
fnp-3049	276	30	their	their	PRON
fnp-3049	276	31	αsyn	αsyn	NOUN
fnp-3049	276	32	pser129	pser129	PROPN
fnp-3049	276	33	immunopositively	immunopositively	ADV
fnp-3049	276	34	stained	stain	VERB
fnp-3049	276	35	area	area	NOUN
fnp-3049	276	36	from	from	ADP
fnp-3049	276	37	week	week	NOUN
fnp-3049	276	38	5	5	NUM
fnp-3049	276	39	to	to	ADP
fnp-3049	276	40	week	week	NOUN
fnp-3049	276	41	13	13	NUM
fnp-3049	276	42	,	,	PUNCT
fnp-3049	276	43	respectively	respectively	ADV
fnp-3049	276	44	in	in	ADP
fnp-3049	276	45	the	the	DET
fnp-3049	276	46	contralateral	contralateral	ADJ
fnp-3049	276	47	aon	aon	PROPN
fnp-3049	276	48	(	(	PUNCT
fnp-3049	276	49	p	p	X
fnp-3049	276	50	=	=	PROPN
fnp-3049	276	51	0.016	0.016	NUM
fnp-3049	276	52	and	and	CCONJ
fnp-3049	276	53	<	<	X
fnp-3049	276	54	0.001	0.001	NUM
fnp-3049	276	55	,	,	PUNCT
fnp-3049	276	56	respectively	respectively	ADV
fnp-3049	276	57	,	,	PUNCT
fnp-3049	276	58	95	95	NUM
fnp-3049	276	59	%	%	NOUN
fnp-3049	276	60	ci	ci	NOUN
fnp-3049	277	1	=	=	NOUN
fnp-3049	277	2	19.2	19.2	NUM
fnp-3049	277	3	233.3	233.3	NUM
fnp-3049	277	4	and	and	CCONJ
fnp-3049	277	5	55.8	55.8	NUM
fnp-3049	277	6	344.4	344.4	NUM
fnp-3049	277	7	)	)	PUNCT
fnp-3049	277	8	.	.	PUNCT
fnp-3049	278	1	in	in	ADP
fnp-3049	278	2	addition	addition	NOUN
fnp-3049	278	3	,	,	PUNCT
fnp-3049	278	4	placebo	placebo	NOUN
fnp-3049	278	5	-	-	PUNCT
fnp-3049	278	6	treated	treat	VERB
fnp-3049	278	7	animals	animal	NOUN
fnp-3049	278	8	had	have	VERB
fnp-3049	278	9	a	a	DET
fnp-3049	278	10	significant	significant	ADJ
fnp-3049	278	11	increase	increase	NOUN
fnp-3049	278	12	of	of	ADP
fnp-3049	278	13	pathology	pathology	NOUN
fnp-3049	278	14	in	in	ADP
fnp-3049	278	15	the	the	DET
fnp-3049	278	16	ipsilateral	ipsilateral	ADJ
fnp-3049	278	17	aon	aon	PROPN
fnp-3049	278	18	from	from	ADP
fnp-3049	278	19	the	the	DET
fnp-3049	278	20	5	5	NUM
fnp-3049	278	21	to	to	PART
fnp-3049	278	22	13	13	NUM
fnp-3049	278	23	-	-	PUNCT
fnp-3049	278	24	week	week	NOUN
fnp-3049	278	25	timepoint	timepoint	NOUN
fnp-3049	278	26	(	(	PUNCT
fnp-3049	278	27	p=0.016	p=0.016	PROPN
fnp-3049	278	28	,	,	PUNCT
fnp-3049	278	29	95	95	NUM
fnp-3049	278	30	%	%	NOUN
fnp-3049	278	31	ci	ci	NOUN
fnp-3049	278	32	18.3	18.3	NUM
fnp-3049	278	33	%	%	NOUN
fnp-3049	278	34	200	200	NUM
fnp-3049	278	35	%	%	NOUN
fnp-3049	278	36	)	)	PUNCT
fnp-3049	278	37	.	.	PUNCT
fnp-3049	279	1	this	this	PRON
fnp-3049	279	2	was	be	AUX
fnp-3049	279	3	not	not	PART
fnp-3049	279	4	observed	observe	VERB
fnp-3049	279	5	for	for	ADP
fnp-3049	279	6	msdc-0160	msdc-0160	ADJ
fnp-3049	279	7	treated	treat	VERB
fnp-3049	279	8	mice	mouse	NOUN
fnp-3049	279	9	.	.	PUNCT
fnp-3049	280	1	when	when	SCONJ
fnp-3049	280	2	comparing	compare	VERB
fnp-3049	280	3	treatment	treatment	NOUN
fnp-3049	280	4	groups	group	NOUN
fnp-3049	280	5	,	,	PUNCT
fnp-3049	280	6	msdc-0160	msdc-0160	ADJ
fnp-3049	280	7	treated	treat	VERB
fnp-3049	280	8	mice	mouse	NOUN
fnp-3049	280	9	had	have	VERB
fnp-3049	280	10	significantly	significantly	ADV
fnp-3049	280	11	more	more	ADJ
fnp-3049	280	12	pser129	pser129	PROPN
fnp-3049	280	13	positive	positive	ADJ
fnp-3049	280	14	signal	signal	NOUN
fnp-3049	280	15	at	at	ADP
fnp-3049	280	16	5	5	NUM
fnp-3049	280	17	weeks	week	NOUN
fnp-3049	280	18	post	post	ADJ
fnp-3049	280	19	-	-	NOUN
fnp-3049	280	20	surgery	surgery	NOUN
fnp-3049	280	21	than	than	ADP
fnp-3049	280	22	the	the	DET
fnp-3049	280	23	placebo	placebo	NOUN
fnp-3049	280	24	group	group	NOUN
fnp-3049	280	25	(	(	PUNCT
fnp-3049	280	26	1.8	1.8	NUM
fnp-3049	280	27	times	time	NOUN
fnp-3049	280	28	more	more	ADJ
fnp-3049	280	29	;	;	PUNCT
fnp-3049	280	30	p=0.02	p=0.02	NOUN
fnp-3049	280	31	95	95	NUM
fnp-3049	280	32	%	%	NOUN
fnp-3049	280	33	ci	ci	NOUN
fnp-3049	280	34	1.16	1.16	NUM
fnp-3049	280	35	2.90	2.90	NUM
fnp-3049	280	36	)	)	PUNCT
fnp-3049	280	37	.	.	PUNCT
fnp-3049	281	1	there	there	PRON
fnp-3049	281	2	is	be	VERB
fnp-3049	281	3	also	also	ADV
fnp-3049	281	4	weak	weak	ADJ
fnp-3049	281	5	evidence	evidence	NOUN
fnp-3049	281	6	that	that	SCONJ
fnp-3049	281	7	this	this	PRON
fnp-3049	281	8	persists	persist	VERB
fnp-3049	281	9	at	at	ADP
fnp-3049	281	10	the	the	DET
fnp-3049	281	11	13	13	NUM
fnp-3049	281	12	-	-	PUNCT
fnp-3049	281	13	week	week	NOUN
fnp-3049	281	14	timepoint	timepoint	NOUN
fnp-3049	281	15	(	(	PUNCT
fnp-3049	281	16	p=0.085	p=0.085	NOUN
fnp-3049	281	17	,	,	PUNCT
fnp-3049	281	18	95	95	NUM
fnp-3049	281	19	%	%	NOUN
fnp-3049	281	20	ci	ci	NOUN
fnp-3049	281	21	0.98	0.98	NUM
fnp-3049	281	22	-	-	SYM
fnp-3049	281	23	1.95	1.95	NUM
fnp-3049	281	24	)	)	PUNCT
fnp-3049	281	25	.	.	PUNCT
fnp-3049	282	1	no	no	DET
fnp-3049	282	2	ni	ni	NOUN
fnp-3049	282	3	-	-	ADJ
fnp-3049	282	4	αsyn	αsyn	PROPN
fnp-3049	282	5	was	be	AUX
fnp-3049	282	6	detected	detect	VERB
fnp-3049	282	7	in	in	ADP
fnp-3049	282	8	the	the	DET
fnp-3049	282	9	pff	pff	NOUN
fnp-3049	282	10	seeding	seed	VERB
fnp-3049	282	11	model	model	NOUN
fnp-3049	282	12	at	at	ADP
fnp-3049	282	13	the	the	DET
fnp-3049	282	14	13	13	NUM
fnp-3049	282	15	-	-	PUNCT
fnp-3049	282	16	week	week	NOUN
fnp-3049	282	17	timepoint	timepoint	NOUN
fnp-3049	282	18	(	(	PUNCT
fnp-3049	282	19	supplementary	supplementary	ADJ
fnp-3049	282	20	fig	fig	NOUN
fnp-3049	282	21	.	.	PUNCT
fnp-3049	283	1	7	7	NUM
fnp-3049	283	2	)	)	PUNCT
fnp-3049	283	3	.	.	PUNCT
fnp-3049	284	1	for	for	ADP
fnp-3049	284	2	detection	detection	NOUN
fnp-3049	284	3	of	of	ADP
fnp-3049	284	4	potential	potential	ADJ
fnp-3049	284	5	amyloid	amyloid	NOUN
fnp-3049	284	6	(	(	PUNCT
fnp-3049	284	7	β	β	NOUN
fnp-3049	284	8	-	-	ADJ
fnp-3049	284	9	sheet	sheet	ADJ
fnp-3049	284	10	rich	rich	ADJ
fnp-3049	284	11	)	)	PUNCT
fnp-3049	284	12	structures	structure	NOUN
fnp-3049	284	13	in	in	ADP
fnp-3049	284	14	the	the	DET
fnp-3049	284	15	pff	pff	NOUN
fnp-3049	284	16	seeding	seeding	NOUN
fnp-3049	284	17	model	model	NOUN
fnp-3049	284	18	and	and	CCONJ
fnp-3049	284	19	the	the	DET
fnp-3049	284	20	aav	aav	NOUN
fnp-3049	284	21	overexpression	overexpression	NOUN
fnp-3049	284	22	model	model	NOUN
fnp-3049	284	23	,	,	PUNCT
fnp-3049	284	24	we	we	PRON
fnp-3049	284	25	used	use	VERB
fnp-3049	284	26	a	a	DET
fnp-3049	284	27	luminescent	luminescent	NOUN
fnp-3049	284	28	conjugated	conjugate	VERB
fnp-3049	284	29	oligothiophene	oligothiophene	NOUN
fnp-3049	284	30	(	(	PUNCT
fnp-3049	284	31	lco	lco	NOUN
fnp-3049	284	32	)	)	PUNCT
fnp-3049	284	33	.	.	PUNCT
fnp-3049	285	1	lcos	lco	NOUN
fnp-3049	285	2	are	be	AUX
fnp-3049	285	3	small	small	ADJ
fnp-3049	285	4	molecules	molecule	NOUN
fnp-3049	285	5	with	with	ADP
fnp-3049	285	6	a	a	DET
fnp-3049	285	7	flexible	flexible	ADJ
fnp-3049	285	8	thiophene	thiophene	NOUN
fnp-3049	285	9	backbone	backbone	NOUN
fnp-3049	285	10	that	that	SCONJ
fnp-3049	285	11	upon	upon	SCONJ
fnp-3049	285	12	binding	bind	VERB
fnp-3049	285	13	to	to	ADP
fnp-3049	285	14	amyloid	amyloid	NOUN
fnp-3049	285	15	structures	structure	NOUN
fnp-3049	285	16	become	become	VERB
fnp-3049	285	17	fluorescent21	fluorescent21	NOUN
fnp-3049	285	18	.	.	PUNCT
fnp-3049	286	1	one	one	NUM
fnp-3049	286	2	such	such	ADJ
fnp-3049	286	3	lco	lco	NOUN
fnp-3049	286	4	,	,	PUNCT
fnp-3049	286	5	which	which	PRON
fnp-3049	286	6	has	have	AUX
fnp-3049	286	7	previously	previously	ADV
fnp-3049	286	8	been	be	AUX
fnp-3049	286	9	shown	show	VERB
fnp-3049	286	10	to	to	PART
fnp-3049	286	11	bind	bind	VERB
fnp-3049	286	12	aggregates	aggregate	NOUN
fnp-3049	286	13	in	in	ADP
fnp-3049	286	14	tissue	tissue	NOUN
fnp-3049	286	15	samples	sample	NOUN
fnp-3049	286	16	from	from	ADP
fnp-3049	286	17	patients	patient	NOUN
fnp-3049	286	18	suffering	suffer	VERB
fnp-3049	286	19	from	from	ADP
fnp-3049	286	20	systemic	systemic	ADJ
fnp-3049	286	21	amyloidosis	amyloidosis	NOUN
fnp-3049	286	22	,	,	PUNCT
fnp-3049	286	23	as	as	ADV
fnp-3049	286	24	well	well	ADV
fnp-3049	286	25	as	as	ADP
fnp-3049	286	26	a	a	DET
fnp-3049	286	27	variety	variety	NOUN
fnp-3049	286	28	of	of	ADP
fnp-3049	286	29	other	other	ADJ
fnp-3049	286	30	disease	disease	NOUN
fnp-3049	286	31	-	-	PUNCT
fnp-3049	286	32	associated	associate	VERB
fnp-3049	286	33	protein	protein	NOUN
fnp-3049	286	34	aggregates	aggregate	NOUN
fnp-3049	286	35	,	,	PUNCT
fnp-3049	286	36	is	be	AUX
fnp-3049	286	37	h	h	NOUN
fnp-3049	286	38	-	-	PUNCT
fnp-3049	286	39	ftaa21	ftaa21	NOUN
fnp-3049	286	40	in	in	ADP
fnp-3049	286	41	the	the	DET
fnp-3049	286	42	aon	aon	PROPN
fnp-3049	286	43	at	at	ADP
fnp-3049	286	44	13	13	NUM
fnp-3049	286	45	weeks	week	NOUN
fnp-3049	286	46	post	post	ADJ
fnp-3049	286	47	-	-	ADJ
fnp-3049	286	48	surgery	surgery	ADJ
fnp-3049	286	49	we	we	PRON
fnp-3049	286	50	observed	observe	VERB
fnp-3049	286	51	ring	ring	NOUN
fnp-3049	286	52	-	-	PUNCT
fnp-3049	286	53	like	like	ADJ
fnp-3049	286	54	h	h	NOUN
fnp-3049	286	55	-	-	PUNCT
fnp-3049	286	56	ftaa	ftaa	ADJ
fnp-3049	286	57	positive	positive	ADJ
fnp-3049	286	58	structures	structure	NOUN
fnp-3049	286	59	(	(	PUNCT
fnp-3049	286	60	fig	fig	NOUN
fnp-3049	286	61	.	.	PUNCT
fnp-3049	287	1	7	7	NUM
fnp-3049	287	2	)	)	PUNCT
fnp-3049	287	3	in	in	ADP
fnp-3049	287	4	the	the	DET
fnp-3049	287	5	pff	pff	PROPN
fnp-3049	287	6	model	model	NOUN
fnp-3049	287	7	.	.	PUNCT
fnp-3049	288	1	these	these	PRON
fnp-3049	288	2	overlapped	overlapped	ADJ
fnp-3049	288	3	with	with	ADP
fnp-3049	288	4	αsyn	αsyn	ADJ
fnp-3049	288	5	pser129	pser129	PROPN
fnp-3049	288	6	antibody	antibody	NOUN
fnp-3049	288	7	staining	stain	VERB
fnp-3049	288	8	,	,	PUNCT
fnp-3049	288	9	indicating	indicate	VERB
fnp-3049	288	10	that	that	SCONJ
fnp-3049	288	11	the	the	DET
fnp-3049	288	12	αsyn	αsyn	PROPN
fnp-3049	288	13	pathology	pathology	NOUN
fnp-3049	288	14	detected	detect	VERB
fnp-3049	288	15	in	in	ADP
fnp-3049	288	16	this	this	DET
fnp-3049	288	17	model	model	NOUN
fnp-3049	288	18	is	be	AUX
fnp-3049	288	19	β	β	NOUN
fnp-3049	288	20	-	-	ADJ
fnp-3049	288	21	sheet	sheet	NOUN
fnp-3049	288	22	rich	rich	ADJ
fnp-3049	288	23	with	with	ADP
fnp-3049	288	24	amyloid	amyloid	NOUN
fnp-3049	288	25	properties	property	NOUN
fnp-3049	288	26	.	.	PUNCT
fnp-3049	289	1	on	on	ADP
fnp-3049	289	2	the	the	DET
fnp-3049	289	3	contrary	contrary	NOUN
fnp-3049	289	4	,	,	PUNCT
fnp-3049	289	5	we	we	PRON
fnp-3049	289	6	did	do	AUX
fnp-3049	289	7	not	not	PART
fnp-3049	289	8	find	find	VERB
fnp-3049	289	9	a	a	DET
fnp-3049	289	10	h	h	NOUN
fnp-3049	289	11	-	-	PUNCT
fnp-3049	289	12	ftaa	ftaa	ADV
fnp-3049	289	13	positive	positive	ADJ
fnp-3049	289	14	signal	signal	NOUN
fnp-3049	289	15	in	in	ADP
fnp-3049	289	16	the	the	DET
fnp-3049	289	17	αsyn	αsyn	PROPN
fnp-3049	289	18	high	high	ADJ
fnp-3049	289	19	group	group	NOUN
fnp-3049	289	20	for	for	ADP
fnp-3049	289	21	the	the	DET
fnp-3049	289	22	aav	aav	PROPN
fnp-3049	289	23	overexpression	overexpression	NOUN
fnp-3049	289	24	model	model	NOUN
fnp-3049	289	25	.	.	PUNCT
fnp-3049	290	1	this	this	DET
fnp-3049	290	2	highlights	highlight	NOUN
fnp-3049	290	3	differences	difference	NOUN
fnp-3049	290	4	in	in	ADP
fnp-3049	290	5	αsyn	αsyn	PROPN
fnp-3049	290	6	assembly	assembly	NOUN
fnp-3049	290	7	states	state	NOUN
fnp-3049	290	8	several	several	ADJ
fnp-3049	290	9	weeks	week	NOUN
fnp-3049	290	10	after	after	ADP
fnp-3049	290	11	surgery	surgery	NOUN
fnp-3049	290	12	in	in	ADP
fnp-3049	290	13	the	the	DET
fnp-3049	290	14	two	two	NUM
fnp-3049	290	15	pd	pd	ADJ
fnp-3049	290	16	rodent	rodent	NOUN
fnp-3049	290	17	models	model	NOUN
fnp-3049	290	18	.	.	PUNCT
fnp-3049	291	1	figure	figure	VERB
fnp-3049	291	2	7	7	NUM
fnp-3049	291	3	.	.	PUNCT
fnp-3049	291	4	h	h	NOUN
fnp-3049	291	5	-	-	PUNCT
fnp-3049	291	6	ftaa	ftaa	ADV
fnp-3049	291	7	positive	positive	ADJ
fnp-3049	291	8	protein	protein	NOUN
fnp-3049	291	9	aggregates	aggregate	NOUN
fnp-3049	291	10	detected	detect	VERB
fnp-3049	291	11	in	in	ADP
fnp-3049	291	12	the	the	DET
fnp-3049	291	13	pff	pff	NOUN
fnp-3049	291	14	seeding	seeding	NOUN
fnp-3049	291	15	model	model	NOUN
fnp-3049	291	16	but	but	CCONJ
fnp-3049	291	17	not	not	PART
fnp-3049	291	18	the	the	DET
fnp-3049	291	19	aav	aav	NOUN
fnp-3049	291	20	overexpression	overexpression	NOUN
fnp-3049	291	21	model	model	NOUN
fnp-3049	291	22	.	.	PUNCT
fnp-3049	292	1	representative	representative	ADJ
fnp-3049	292	2	images	image	NOUN
fnp-3049	292	3	of	of	ADP
fnp-3049	292	4	the	the	DET
fnp-3049	292	5	aon	aon	PROPN
fnp-3049	292	6	and	and	CCONJ
fnp-3049	292	7	the	the	DET
fnp-3049	292	8	sn	sn	PROPN
fnp-3049	292	9	for	for	ADP
fnp-3049	292	10	the	the	DET
fnp-3049	292	11	pff	pff	PROPN
fnp-3049	292	12	model	model	NOUN
fnp-3049	292	13	and	and	CCONJ
fnp-3049	292	14	the	the	DET
fnp-3049	292	15	aav	aav	NOUN
fnp-3049	292	16	overexpression	overexpression	NOUN
fnp-3049	292	17	model	model	NOUN
fnp-3049	292	18	,	,	PUNCT
fnp-3049	292	19	respectively	respectively	ADV
fnp-3049	292	20	.	.	PUNCT
fnp-3049	293	1	the	the	DET
fnp-3049	293	2	h	h	NOUN
fnp-3049	293	3	-	-	PUNCT
fnp-3049	293	4	ftaa	ftaa	ADV
fnp-3049	293	5	positive	positive	ADJ
fnp-3049	293	6	signal	signal	NOUN
fnp-3049	293	7	(	(	PUNCT
fnp-3049	293	8	green	green	NOUN
fnp-3049	293	9	)	)	PUNCT
fnp-3049	293	10	detected	detect	VERB
fnp-3049	293	11	in	in	ADP
fnp-3049	293	12	the	the	DET
fnp-3049	293	13	aon	aon	PROPN
fnp-3049	293	14	13	13	NUM
fnp-3049	293	15	weeks	week	NOUN
fnp-3049	293	16	following	follow	VERB
fnp-3049	293	17	surgery	surgery	NOUN
fnp-3049	293	18	co	co	VERB
fnp-3049	293	19	-	-	VERB
fnp-3049	293	20	localizes	localize	VERB
fnp-3049	293	21	with	with	ADP
fnp-3049	293	22	the	the	DET
fnp-3049	293	23	αsyn	αsyn	ADJ
fnp-3049	293	24	pser129	pser129	PROPN
fnp-3049	293	25	signal	signal	NOUN
fnp-3049	293	26	(	(	PUNCT
fnp-3049	293	27	pink	pink	ADJ
fnp-3049	293	28	)	)	PUNCT
fnp-3049	293	29	.	.	PUNCT
fnp-3049	294	1	dapi	dapi	PROPN
fnp-3049	294	2	was	be	AUX
fnp-3049	294	3	used	use	VERB
fnp-3049	294	4	to	to	PART
fnp-3049	294	5	visualize	visualize	VERB
fnp-3049	294	6	the	the	DET
fnp-3049	294	7	cell	cell	NOUN
fnp-3049	294	8	nuclei	nucleus	NOUN
fnp-3049	294	9	(	(	PUNCT
fnp-3049	294	10	blue	blue	ADJ
fnp-3049	294	11	)	)	PUNCT
fnp-3049	294	12	,	,	PUNCT
fnp-3049	294	13	scale	scale	NOUN
fnp-3049	294	14	bar	bar	NOUN
fnp-3049	294	15	=	=	PUNCT
fnp-3049	294	16	10	10	NUM
fnp-3049	294	17	μm	μm	NUM
fnp-3049	294	18	and	and	CCONJ
fnp-3049	294	19	3	3	NUM
fnp-3049	294	20	animals	animal	NOUN
fnp-3049	294	21	per	per	ADP
fnp-3049	294	22	group	group	NOUN
fnp-3049	294	23	were	be	AUX
fnp-3049	294	24	analyzed	analyze	VERB
fnp-3049	294	25	.	.	PUNCT
fnp-3049	295	1	given	give	VERB
fnp-3049	295	2	the	the	DET
fnp-3049	295	3	absence	absence	NOUN
fnp-3049	295	4	of	of	ADP
fnp-3049	295	5	any	any	DET
fnp-3049	295	6	therapeutic	therapeutic	ADJ
fnp-3049	295	7	benefits	benefit	NOUN
fnp-3049	295	8	in	in	ADP
fnp-3049	295	9	the	the	DET
fnp-3049	295	10	pff	pff	PROPN
fnp-3049	295	11	model	model	NOUN
fnp-3049	295	12	,	,	PUNCT
fnp-3049	295	13	we	we	PRON
fnp-3049	295	14	again	again	ADV
fnp-3049	295	15	investigated	investigate	VERB
fnp-3049	295	16	the	the	DET
fnp-3049	295	17	presence	presence	NOUN
fnp-3049	295	18	of	of	ADP
fnp-3049	295	19	inflammation	inflammation	NOUN
fnp-3049	295	20	via	via	ADP
fnp-3049	295	21	measuring	measure	VERB
fnp-3049	295	22	the	the	DET
fnp-3049	295	23	hydraulic	hydraulic	ADJ
fnp-3049	295	24	radius	radius	NOUN
fnp-3049	295	25	(	(	PUNCT
fnp-3049	295	26	area	area	NOUN
fnp-3049	295	27	/	/	SYM
fnp-3049	295	28	perimeter	perimeter	NOUN
fnp-3049	295	29	ratio	ratio	NOUN
fnp-3049	295	30	)	)	PUNCT
fnp-3049	295	31	of	of	ADP
fnp-3049	295	32	microglia	microglia	NOUN
fnp-3049	295	33	in	in	ADP
fnp-3049	295	34	the	the	DET
fnp-3049	295	35	aon	aon	PROPN
fnp-3049	295	36	13	13	NUM
fnp-3049	295	37	weeks	week	NOUN
fnp-3049	295	38	post	post	ADJ
fnp-3049	295	39	-	-	NOUN
fnp-3049	295	40	surgery	surgery	NOUN
fnp-3049	295	41	.	.	PUNCT
fnp-3049	296	1	when	when	SCONJ
fnp-3049	296	2	we	we	PRON
fnp-3049	296	3	compared	compare	VERB
fnp-3049	296	4	the	the	DET
fnp-3049	296	5	injected	inject	VERB
fnp-3049	296	6	side	side	NOUN
fnp-3049	296	7	with	with	ADP
fnp-3049	296	8	the	the	DET
fnp-3049	296	9	non	non	ADJ
fnp-3049	296	10	-	-	ADJ
fnp-3049	296	11	injected	injected	ADJ
fnp-3049	296	12	side	side	NOUN
fnp-3049	296	13	,	,	PUNCT
fnp-3049	296	14	we	we	PRON
fnp-3049	296	15	found	find	VERB
fnp-3049	296	16	no	no	DET
fnp-3049	296	17	significant	significant	ADJ
fnp-3049	296	18	change	change	NOUN
fnp-3049	296	19	in	in	ADP
fnp-3049	296	20	microglia	microglia	ADJ
fnp-3049	296	21	morphology	morphology	NOUN
fnp-3049	296	22	(	(	PUNCT
fnp-3049	296	23	fig	fig	NOUN
fnp-3049	296	24	.	.	PUNCT
fnp-3049	297	1	8a	8a	NUM
fnp-3049	297	2	,	,	PUNCT
fnp-3049	297	3	b	b	NOUN
fnp-3049	297	4	)	)	PUNCT
fnp-3049	297	5	.	.	PUNCT
fnp-3049	298	1	furthermore	furthermore	ADV
fnp-3049	298	2	,	,	PUNCT
fnp-3049	298	3	we	we	PRON
fnp-3049	298	4	did	do	AUX
fnp-3049	298	5	not	not	PART
fnp-3049	298	6	detect	detect	VERB
fnp-3049	298	7	any	any	DET
fnp-3049	298	8	significant	significant	ADJ
fnp-3049	298	9	difference	difference	NOUN
fnp-3049	298	10	between	between	ADP
fnp-3049	298	11	pbs	pbs	PROPN
fnp-3049	298	12	and	and	CCONJ
fnp-3049	298	13	pffs	pff	NOUN
fnp-3049	298	14	groups	group	NOUN
fnp-3049	298	15	or	or	CCONJ
fnp-3049	298	16	differences	difference	NOUN
fnp-3049	298	17	between	between	ADP
fnp-3049	298	18	animals	animal	NOUN
fnp-3049	298	19	treated	treat	VERB
fnp-3049	298	20	with	with	ADP
fnp-3049	298	21	placebo	placebo	NOUN
fnp-3049	298	22	or	or	CCONJ
fnp-3049	298	23	msdc-0160	msdc-0160	NOUN
fnp-3049	298	24	.	.	PUNCT
fnp-3049	299	1	in	in	ADP
fnp-3049	299	2	addition	addition	NOUN
fnp-3049	299	3	,	,	PUNCT
fnp-3049	299	4	by	by	ADP
fnp-3049	299	5	quantifying	quantify	VERB
fnp-3049	299	6	lamp2	lamp2	PROPN
fnp-3049	299	7	-	-	PUNCT
fnp-3049	299	8	positive	positive	ADJ
fnp-3049	299	9	staining	staining	NOUN
fnp-3049	299	10	we	we	PRON
fnp-3049	299	11	do	do	AUX
fnp-3049	299	12	not	not	PART
fnp-3049	299	13	observe	observe	VERB
fnp-3049	299	14	any	any	DET
fnp-3049	299	15	lysosomal	lysosomal	ADJ
fnp-3049	299	16	deficits	deficit	NOUN
fnp-3049	299	17	in	in	ADP
fnp-3049	299	18	the	the	DET
fnp-3049	299	19	aon	aon	PROPN
fnp-3049	299	20	13	13	NUM
fnp-3049	299	21	weeks	week	NOUN
fnp-3049	299	22	post	post	ADJ
fnp-3049	299	23	-	-	ADJ
fnp-3049	299	24	surgery	surgery	ADJ
fnp-3049	299	25	(	(	PUNCT
fnp-3049	299	26	fig	fig	NOUN
fnp-3049	299	27	.	.	PUNCT
fnp-3049	300	1	8c	8c	NUM
fnp-3049	300	2	,	,	PUNCT
fnp-3049	300	3	d	d	NOUN
fnp-3049	300	4	)	)	PUNCT
fnp-3049	300	5	.	.	PUNCT
fnp-3049	301	1	taken	take	VERB
fnp-3049	301	2	together	together	ADV
fnp-3049	301	3	,	,	PUNCT
fnp-3049	301	4	in	in	ADP
fnp-3049	301	5	absence	absence	NOUN
fnp-3049	301	6	of	of	ADP
fnp-3049	301	7	lysosomal	lysosomal	ADJ
fnp-3049	301	8	deficits	deficit	NOUN
fnp-3049	301	9	and	and	CCONJ
fnp-3049	301	10	microglial	microglial	ADJ
fnp-3049	301	11	changes	change	NOUN
fnp-3049	301	12	,	,	PUNCT
fnp-3049	301	13	a	a	DET
fnp-3049	301	14	metabolic	metabolic	NOUN
fnp-3049	301	15	switch	switch	NOUN
fnp-3049	301	16	,	,	PUNCT
fnp-3049	301	17	by	by	ADP
fnp-3049	301	18	inhibiting	inhibit	VERB
fnp-3049	301	19	the	the	DET
fnp-3049	301	20	mpc	mpc	NOUN
fnp-3049	301	21	,	,	PUNCT
fnp-3049	301	22	does	do	AUX
fnp-3049	301	23	not	not	PART
fnp-3049	301	24	reduce	reduce	VERB
fnp-3049	301	25	accumulation	accumulation	NOUN
fnp-3049	301	26	of	of	ADP
fnp-3049	301	27	αsyn	αsyn	NOUN
fnp-3049	301	28	pser129	pser129	PROPN
fnp-3049	301	29	in	in	ADP
fnp-3049	301	30	mice	mouse	NOUN
fnp-3049	301	31	injected	inject	VERB
fnp-3049	301	32	with	with	ADP
fnp-3049	301	33	pffs	pff	NOUN
fnp-3049	301	34	in	in	ADP
fnp-3049	301	35	the	the	DET
fnp-3049	301	36	olfactory	olfactory	NOUN
fnp-3049	301	37	bulb	bulb	PROPN
fnp-3049	301	38	.	.	PUNCT
fnp-3049	302	1	figure	figure	VERB
fnp-3049	302	2	8	8	NUM
fnp-3049	302	3	.	.	PUNCT
fnp-3049	303	1	absence	absence	NOUN
fnp-3049	303	2	of	of	ADP
fnp-3049	303	3	inflammatory	inflammatory	ADJ
fnp-3049	303	4	or	or	CCONJ
fnp-3049	303	5	autophagy	autophagy	ADJ
fnp-3049	303	6	deficits	deficit	NOUN
fnp-3049	303	7	13	13	NUM
fnp-3049	303	8	-	-	PUNCT
fnp-3049	303	9	weeks	week	NOUN
fnp-3049	303	10	post	post	NOUN
fnp-3049	303	11	pff	pff	PROPN
fnp-3049	303	12	surgery	surgery	NOUN
fnp-3049	303	13	.	.	PUNCT
fnp-3049	304	1	a	a	DET
fnp-3049	304	2	)	)	PUNCT
fnp-3049	304	3	representative	representative	ADJ
fnp-3049	304	4	images	image	NOUN
fnp-3049	304	5	of	of	ADP
fnp-3049	304	6	iba-1	iba-1	PUNCT
fnp-3049	304	7	positive	positive	ADJ
fnp-3049	304	8	staining	staining	NOUN
fnp-3049	304	9	in	in	ADP
fnp-3049	304	10	the	the	DET
fnp-3049	304	11	ipsilateral	ipsilateral	ADJ
fnp-3049	304	12	aon	aon	PROPN
fnp-3049	304	13	,	,	PUNCT
fnp-3049	304	14	scale	scale	NOUN
fnp-3049	304	15	bar	bar	NOUN
fnp-3049	304	16	=	=	PUNCT
fnp-3049	304	17	50	50	NUM
fnp-3049	304	18	μm	μm	NOUN
fnp-3049	304	19	.	.	PUNCT
fnp-3049	305	1	b	b	X
fnp-3049	305	2	)	)	PUNCT
fnp-3049	305	3	quantification	quantification	NOUN
fnp-3049	305	4	of	of	ADP
fnp-3049	305	5	microglial	microglial	ADJ
fnp-3049	305	6	hydraulic	hydraulic	ADJ
fnp-3049	305	7	radius	radius	NOUN
fnp-3049	305	8	as	as	ADP
fnp-3049	305	9	a	a	DET
fnp-3049	305	10	measure	measure	NOUN
fnp-3049	305	11	of	of	ADP
fnp-3049	305	12	microglial	microglial	ADJ
fnp-3049	305	13	ramification	ramification	NOUN
fnp-3049	305	14	and	and	CCONJ
fnp-3049	305	15	activation	activation	NOUN
fnp-3049	305	16	(	(	PUNCT
fnp-3049	305	17	n	n	NOUN
fnp-3049	305	18	=	=	SYM
fnp-3049	305	19	5	5	NUM
fnp-3049	305	20	-	-	SYM
fnp-3049	305	21	6	6	NUM
fnp-3049	305	22	/	/	SYM
fnp-3049	305	23	group	group	NOUN
fnp-3049	305	24	,	,	PUNCT
fnp-3049	305	25	sem	sem	PROPN
fnp-3049	305	26	)	)	PUNCT
fnp-3049	305	27	,	,	PUNCT
fnp-3049	305	28	shows	show	VERB
fnp-3049	305	29	no	no	DET
fnp-3049	305	30	microglial	microglial	ADJ
fnp-3049	305	31	activation	activation	NOUN
fnp-3049	305	32	following	follow	VERB
fnp-3049	305	33	pff	pff	PROPN
fnp-3049	305	34	injection	injection	NOUN
fnp-3049	305	35	.	.	PUNCT
fnp-3049	306	1	c	c	X
fnp-3049	306	2	)	)	PUNCT
fnp-3049	306	3	representative	representative	ADJ
fnp-3049	306	4	images	image	NOUN
fnp-3049	306	5	of	of	ADP
fnp-3049	306	6	lamp2	lamp2	NOUN
fnp-3049	306	7	positive	positive	ADJ
fnp-3049	306	8	staining	stain	VERB
fnp-3049	306	9	(	(	PUNCT
fnp-3049	306	10	green	green	ADJ
fnp-3049	306	11	)	)	PUNCT
fnp-3049	306	12	in	in	ADP
fnp-3049	306	13	the	the	DET
fnp-3049	306	14	ipsilateral	ipsilateral	ADJ
fnp-3049	306	15	aon	aon	PROPN
fnp-3049	306	16	.	.	PUNCT
fnp-3049	307	1	dapi	dapi	PROPN
fnp-3049	307	2	(	(	PUNCT
fnp-3049	307	3	blue	blue	PROPN
fnp-3049	307	4	)	)	PUNCT
fnp-3049	307	5	was	be	AUX
fnp-3049	307	6	used	use	VERB
fnp-3049	307	7	to	to	PART
fnp-3049	307	8	visualize	visualize	VERB
fnp-3049	307	9	the	the	DET
fnp-3049	307	10	cell	cell	NOUN
fnp-3049	307	11	nuclei	nucleus	NOUN
fnp-3049	307	12	.	.	PUNCT
fnp-3049	308	1	scale	scale	NOUN
fnp-3049	308	2	bar	bar	NOUN
fnp-3049	308	3	=	=	PUNCT
fnp-3049	308	4	10	10	NUM
fnp-3049	308	5	μm	μm	NUM
fnp-3049	308	6	d	d	NOUN
fnp-3049	308	7	)	)	PUNCT
fnp-3049	308	8	fluorescent	fluorescent	NOUN
fnp-3049	308	9	lamp2	lamp2	NOUN
fnp-3049	308	10	quantification	quantification	NOUN
fnp-3049	308	11	after	after	ADP
fnp-3049	308	12	adding	add	VERB
fnp-3049	308	13	adaptive	adaptive	ADJ
fnp-3049	308	14	triangle	triangle	NOUN
fnp-3049	308	15	thresholding	thresholde	VERB
fnp-3049	308	16	in	in	ADP
fnp-3049	308	17	the	the	DET
fnp-3049	308	18	aon	aon	PROPN
fnp-3049	308	19	(	(	PUNCT
fnp-3049	308	20	n	n	NOUN
fnp-3049	308	21	=	=	SYM
fnp-3049	308	22	6	6	NUM
fnp-3049	308	23	,	,	PUNCT
fnp-3049	308	24	sem	sem	ADJ
fnp-3049	308	25	)	)	PUNCT
fnp-3049	308	26	discussion	discussion	NOUN
fnp-3049	308	27	improving	improve	VERB
fnp-3049	308	28	metabolism	metabolism	NOUN
fnp-3049	308	29	,	,	PUNCT
fnp-3049	308	30	reducing	reduce	VERB
fnp-3049	308	31	inflammation	inflammation	NOUN
fnp-3049	308	32	and	and	CCONJ
fnp-3049	308	33	inhibiting	inhibit	VERB
fnp-3049	308	34	the	the	DET
fnp-3049	308	35	aggregation	aggregation	NOUN
fnp-3049	308	36	or	or	CCONJ
fnp-3049	308	37	the	the	DET
fnp-3049	308	38	spread	spread	NOUN
fnp-3049	308	39	of	of	ADP
fnp-3049	308	40	pathological	pathological	ADJ
fnp-3049	308	41	αsyn	αsyn	NOUN
fnp-3049	308	42	are	be	AUX
fnp-3049	308	43	considered	consider	VERB
fnp-3049	308	44	promising	promise	VERB
fnp-3049	308	45	therapeutic	therapeutic	ADJ
fnp-3049	308	46	targets	target	NOUN
fnp-3049	308	47	for	for	ADP
fnp-3049	308	48	the	the	DET
fnp-3049	308	49	treatment	treatment	NOUN
fnp-3049	308	50	of	of	ADP
fnp-3049	308	51	pd	pd	PROPN
fnp-3049	308	52	.	.	PROPN
fnp-3049	309	1	through	through	ADP
fnp-3049	309	2	preclinical	preclinical	ADJ
fnp-3049	309	3	and	and	CCONJ
fnp-3049	309	4	clinical	clinical	ADJ
fnp-3049	309	5	work	work	NOUN
fnp-3049	309	6	,	,	PUNCT
fnp-3049	309	7	it	it	PRON
fnp-3049	309	8	has	have	AUX
fnp-3049	309	9	been	be	AUX
fnp-3049	309	10	suggested	suggest	VERB
fnp-3049	309	11	that	that	SCONJ
fnp-3049	309	12	anti	anti	ADJ
fnp-3049	309	13	-	-	ADJ
fnp-3049	309	14	diabetic	diabetic	ADJ
fnp-3049	309	15	drugs	drug	NOUN
fnp-3049	309	16	might	might	AUX
fnp-3049	309	17	hold	hold	VERB
fnp-3049	309	18	this	this	DET
fnp-3049	309	19	promise22	promise22	NOUN
fnp-3049	309	20	.	.	PUNCT
fnp-3049	310	1	we	we	PRON
fnp-3049	310	2	have	have	AUX
fnp-3049	310	3	previously	previously	ADV
fnp-3049	310	4	shown	show	VERB
fnp-3049	310	5	that	that	SCONJ
fnp-3049	310	6	msdc-0160	msdc-0160	ADJ
fnp-3049	310	7	,	,	PUNCT
fnp-3049	310	8	a	a	DET
fnp-3049	310	9	type	type	NOUN
fnp-3049	310	10	2	2	NUM
fnp-3049	310	11	diabetes	diabetes	NOUN
fnp-3049	310	12	insulin	insulin	NOUN
fnp-3049	310	13	sensitizer	sensitizer	NOUN
fnp-3049	310	14	,	,	PUNCT
fnp-3049	310	15	can	can	AUX
fnp-3049	310	16	ameliorate	ameliorate	VERB
fnp-3049	310	17	pathology	pathology	NOUN
fnp-3049	310	18	in	in	ADP
fnp-3049	310	19	an	an	DET
fnp-3049	310	20	acute	acute	NOUN
fnp-3049	310	21	(	(	PUNCT
fnp-3049	310	22	1	1	NUM
fnp-3049	310	23	-	-	PUNCT
fnp-3049	310	24	methyl-4	methyl-4	NUM
fnp-3049	310	25	-	-	PUNCT
fnp-3049	310	26	phenyl-1,2,3,6	phenyl-1,2,3,6	NOUN
fnp-3049	310	27	-	-	PUNCT
fnp-3049	310	28	tetrahydropyridine	tetrahydropyridine	ADJ
fnp-3049	310	29	,	,	PUNCT
fnp-3049	310	30	mptp	mptp	PROPN
fnp-3049	310	31	)	)	PUNCT
fnp-3049	310	32	and	and	CCONJ
fnp-3049	310	33	slowly	slowly	ADV
fnp-3049	310	34	progressive	progressive	ADJ
fnp-3049	310	35	,	,	PUNCT
fnp-3049	310	36	genetic	genetic	ADJ
fnp-3049	310	37	(	(	PUNCT
fnp-3049	310	38	engrailed1+/-	engrailed1+/-	NOUN
fnp-3049	310	39	)	)	PUNCT
fnp-3049	310	40	model	model	NOUN
fnp-3049	310	41	of	of	ADP
fnp-3049	310	42	pd	pd	PROPN
fnp-3049	310	43	and	and	CCONJ
fnp-3049	310	44	that	that	SCONJ
fnp-3049	310	45	these	these	DET
fnp-3049	310	46	effects	effect	NOUN
fnp-3049	310	47	occurred	occur	VERB
fnp-3049	310	48	via	via	ADP
fnp-3049	310	49	modulation	modulation	NOUN
fnp-3049	310	50	of	of	ADP
fnp-3049	310	51	the	the	DET
fnp-3049	310	52	mpc	mpc	NOUN
fnp-3049	310	53	and	and	CCONJ
fnp-3049	310	54	its	its	PRON
fnp-3049	310	55	downstream	downstream	ADJ
fnp-3049	310	56	effect	effect	NOUN
fnp-3049	310	57	involving	involve	VERB
fnp-3049	310	58	the	the	DET
fnp-3049	310	59	mtor	mtor	PROPN
fnp-3049	310	60	pathway10	pathway10	NOUN
fnp-3049	310	61	.	.	PUNCT
fnp-3049	311	1	since	since	SCONJ
fnp-3049	311	2	the	the	DET
fnp-3049	311	3	direct	direct	ADJ
fnp-3049	311	4	effects	effect	NOUN
fnp-3049	311	5	of	of	ADP
fnp-3049	311	6	inhibiting	inhibit	VERB
fnp-3049	311	7	mpc	mpc	NOUN
fnp-3049	311	8	in	in	ADP
fnp-3049	311	9	chronic	chronic	ADJ
fnp-3049	311	10	models	model	NOUN
fnp-3049	311	11	of	of	ADP
fnp-3049	311	12	αsyn	αsyn	ADJ
fnp-3049	311	13	aggregation	aggregation	NOUN
fnp-3049	311	14	had	have	AUX
fnp-3049	311	15	not	not	PART
fnp-3049	311	16	been	be	AUX
fnp-3049	311	17	studied	study	VERB
fnp-3049	311	18	,	,	PUNCT
fnp-3049	311	19	we	we	PRON
fnp-3049	311	20	asked	ask	VERB
fnp-3049	311	21	if	if	SCONJ
fnp-3049	311	22	msdc-0160	msdc-0160	ADJ
fnp-3049	311	23	could	could	AUX
fnp-3049	311	24	lower	lower	VERB
fnp-3049	311	25	the	the	DET
fnp-3049	311	26	levels	level	NOUN
fnp-3049	311	27	of	of	ADP
fnp-3049	311	28	αsyn	αsyn	NOUN
fnp-3049	311	29	in	in	ADP
fnp-3049	311	30	two	two	NUM
fnp-3049	311	31	different	different	ADJ
fnp-3049	311	32	,	,	PUNCT
fnp-3049	311	33	chronic	chronic	ADJ
fnp-3049	311	34	and	and	CCONJ
fnp-3049	311	35	progressive	progressive	ADJ
fnp-3049	311	36	αsyn	αsyn	NOUN
fnp-3049	311	37	-	-	PUNCT
fnp-3049	311	38	based	base	VERB
fnp-3049	311	39	animal	animal	NOUN
fnp-3049	311	40	models	model	NOUN
fnp-3049	311	41	of	of	ADP
fnp-3049	311	42	pd	pd	PROPN
fnp-3049	311	43	.	.	PROPN
fnp-3049	312	1	in	in	ADP
fnp-3049	312	2	our	our	PRON
fnp-3049	312	3	first	first	ADJ
fnp-3049	312	4	model	model	NOUN
fnp-3049	312	5	,	,	PUNCT
fnp-3049	312	6	αsyn	αsyn	PROPN
fnp-3049	312	7	is	be	AUX
fnp-3049	312	8	expressed	express	VERB
fnp-3049	312	9	via	via	ADP
fnp-3049	312	10	viral	viral	ADJ
fnp-3049	312	11	vector	vector	NOUN
fnp-3049	312	12	delivery	delivery	NOUN
fnp-3049	312	13	in	in	ADP
fnp-3049	312	14	the	the	DET
fnp-3049	312	15	rat	rat	NOUN
fnp-3049	312	16	sn	sn	NOUN
fnp-3049	312	17	resulting	result	VERB
fnp-3049	312	18	in	in	ADP
fnp-3049	312	19	aggregation	aggregation	NOUN
fnp-3049	312	20	and	and	CCONJ
fnp-3049	312	21	progressive	progressive	ADJ
fnp-3049	312	22	accumulation	accumulation	NOUN
fnp-3049	312	23	of	of	ADP
fnp-3049	312	24	insoluble	insoluble	ADJ
fnp-3049	312	25	αsyn	αsyn	NOUN
fnp-3049	312	26	.	.	PUNCT
fnp-3049	313	1	after	after	ADP
fnp-3049	313	2	four	four	NUM
fnp-3049	313	3	months	month	NOUN
fnp-3049	313	4	,	,	PUNCT
fnp-3049	313	5	no	no	DET
fnp-3049	313	6	significant	significant	ADJ
fnp-3049	313	7	motor	motor	NOUN
fnp-3049	313	8	abnormalities	abnormality	NOUN
fnp-3049	313	9	with	with	ADP
fnp-3049	313	10	moderate	moderate	ADJ
fnp-3049	313	11	neurodegeneration	neurodegeneration	NOUN
fnp-3049	313	12	were	be	AUX
fnp-3049	313	13	observed	observe	VERB
fnp-3049	313	14	but	but	CCONJ
fnp-3049	313	15	,	,	PUNCT
fnp-3049	313	16	unexpectedly	unexpectedly	ADV
fnp-3049	313	17	,	,	PUNCT
fnp-3049	313	18	animals	animal	NOUN
fnp-3049	313	19	that	that	PRON
fnp-3049	313	20	were	be	AUX
fnp-3049	313	21	treated	treat	VERB
fnp-3049	313	22	with	with	ADP
fnp-3049	313	23	msdc-0160	msdc-0160	ADJ
fnp-3049	313	24	exhibited	exhibit	VERB
fnp-3049	313	25	increased	increase	VERB
fnp-3049	313	26	levels	level	NOUN
fnp-3049	313	27	of	of	ADP
fnp-3049	313	28	aggregated	aggregate	VERB
fnp-3049	313	29	αsyn	αsyn	NOUN
fnp-3049	313	30	.	.	PUNCT
fnp-3049	314	1	in	in	ADP
fnp-3049	314	2	the	the	DET
fnp-3049	314	3	second	second	ADJ
fnp-3049	314	4	model	model	NOUN
fnp-3049	314	5	,	,	PUNCT
fnp-3049	314	6	pffs	pff	NOUN
fnp-3049	314	7	were	be	AUX
fnp-3049	314	8	injected	inject	VERB
fnp-3049	314	9	in	in	ADP
fnp-3049	314	10	the	the	DET
fnp-3049	314	11	ob	ob	NOUN
fnp-3049	314	12	of	of	ADP
fnp-3049	314	13	mice	mouse	NOUN
fnp-3049	314	14	and	and	CCONJ
fnp-3049	314	15	allowed	allow	VERB
fnp-3049	314	16	to	to	PART
fnp-3049	314	17	seed	seed	VERB
fnp-3049	314	18	and	and	CCONJ
fnp-3049	314	19	spread	spread	VERB
fnp-3049	314	20	to	to	ADP
fnp-3049	314	21	connected	connected	ADJ
fnp-3049	314	22	regions	region	NOUN
fnp-3049	314	23	.	.	PUNCT
fnp-3049	315	1	five	five	NUM
fnp-3049	315	2	weeks	week	NOUN
fnp-3049	315	3	after	after	ADP
fnp-3049	315	4	pff	pff	PROPN
fnp-3049	315	5	injection	injection	NOUN
fnp-3049	315	6	,	,	PUNCT
fnp-3049	315	7	we	we	PRON
fnp-3049	315	8	observed	observe	VERB
fnp-3049	315	9	an	an	DET
fnp-3049	315	10	increase	increase	NOUN
fnp-3049	315	11	in	in	ADP
fnp-3049	315	12	αsyn	αsyn	ADJ
fnp-3049	315	13	pathology	pathology	NOUN
fnp-3049	315	14	burden	burden	NOUN
fnp-3049	315	15	when	when	SCONJ
fnp-3049	315	16	mice	mouse	NOUN
fnp-3049	315	17	were	be	AUX
fnp-3049	315	18	treated	treat	VERB
fnp-3049	315	19	with	with	ADP
fnp-3049	315	20	msdc-0160	msdc-0160	ADJ
fnp-3049	315	21	.	.	PUNCT
fnp-3049	316	1	this	this	DET
fnp-3049	316	2	effect	effect	NOUN
fnp-3049	316	3	was	be	AUX
fnp-3049	316	4	transient	transient	ADJ
fnp-3049	316	5	and	and	CCONJ
fnp-3049	316	6	at	at	ADP
fnp-3049	316	7	the	the	DET
fnp-3049	316	8	later	later	ADJ
fnp-3049	316	9	,	,	PUNCT
fnp-3049	316	10	13	13	NUM
fnp-3049	316	11	-	-	PUNCT
fnp-3049	316	12	week	week	NOUN
fnp-3049	316	13	timepoint	timepoint	NOUN
fnp-3049	316	14	no	no	DET
fnp-3049	316	15	significant	significant	ADJ
fnp-3049	316	16	difference	difference	NOUN
fnp-3049	316	17	between	between	ADP
fnp-3049	316	18	the	the	DET
fnp-3049	316	19	two	two	NUM
fnp-3049	316	20	treatment	treatment	NOUN
fnp-3049	316	21	groups	group	NOUN
fnp-3049	316	22	could	could	AUX
fnp-3049	316	23	be	be	AUX
fnp-3049	316	24	observed	observe	VERB
fnp-3049	316	25	.	.	PUNCT
fnp-3049	317	1	both	both	CCONJ
fnp-3049	317	2	the	the	DET
fnp-3049	317	3	αsyn	αsyn	ADJ
fnp-3049	317	4	viral	viral	ADJ
fnp-3049	317	5	vector	vector	NOUN
fnp-3049	317	6	and	and	CCONJ
fnp-3049	317	7	the	the	DET
fnp-3049	317	8	αsyn	αsyn	NOUN
fnp-3049	317	9	pff	pff	NOUN
fnp-3049	317	10	seeding	seeding	NOUN
fnp-3049	317	11	models	model	NOUN
fnp-3049	317	12	are	be	AUX
fnp-3049	317	13	based	base	VERB
fnp-3049	317	14	on	on	ADP
fnp-3049	317	15	the	the	DET
fnp-3049	317	16	introduction	introduction	NOUN
fnp-3049	317	17	of	of	ADP
fnp-3049	317	18	exogenous	exogenous	ADJ
fnp-3049	317	19	αsyn	αsyn	NOUN
fnp-3049	317	20	that	that	PRON
fnp-3049	317	21	leads	lead	VERB
fnp-3049	317	22	to	to	ADP
fnp-3049	317	23	progressive	progressive	ADJ
fnp-3049	317	24	accumulation	accumulation	NOUN
fnp-3049	317	25	of	of	ADP
fnp-3049	317	26	phosphorylated	phosphorylate	VERB
fnp-3049	317	27	and	and	CCONJ
fnp-3049	317	28	misfolded	misfolde	VERB
fnp-3049	317	29	αsyn	αsyn	NOUN
fnp-3049	317	30	over	over	ADP
fnp-3049	317	31	time	time	NOUN
fnp-3049	317	32	.	.	PUNCT
fnp-3049	318	1	the	the	DET
fnp-3049	318	2	viral	viral	ADJ
fnp-3049	318	3	vector	vector	NOUN
fnp-3049	318	4	model	model	NOUN
fnp-3049	318	5	results	result	NOUN
fnp-3049	318	6	in	in	ADP
fnp-3049	318	7	local	local	ADJ
fnp-3049	318	8	accumulation	accumulation	NOUN
fnp-3049	318	9	of	of	ADP
fnp-3049	318	10	highly	highly	ADV
fnp-3049	318	11	concentrated	concentrated	ADJ
fnp-3049	318	12	but	but	CCONJ
fnp-3049	318	13	soluble	soluble	ADJ
fnp-3049	318	14	αsyn	αsyn	NOUN
fnp-3049	318	15	that	that	PRON
fnp-3049	318	16	assembles	assemble	VERB
fnp-3049	318	17	into	into	ADP
fnp-3049	318	18	insoluble	insoluble	ADJ
fnp-3049	318	19	αsyn	αsyn	NOUN
fnp-3049	318	20	,	,	PUNCT
fnp-3049	318	21	whereas	whereas	SCONJ
fnp-3049	318	22	the	the	DET
fnp-3049	318	23	pff	pff	PROPN
fnp-3049	318	24	model	model	NOUN
fnp-3049	318	25	is	be	AUX
fnp-3049	318	26	based	base	VERB
fnp-3049	318	27	on	on	ADP
fnp-3049	318	28	the	the	DET
fnp-3049	318	29	introduction	introduction	NOUN
fnp-3049	318	30	of	of	ADP
fnp-3049	318	31	aggregated	aggregated	ADJ
fnp-3049	318	32	,	,	PUNCT
fnp-3049	318	33	seeding	seeding	NOUN
fnp-3049	318	34	-	-	PUNCT
fnp-3049	318	35	potent	potent	ADJ
fnp-3049	318	36	αsyn	αsyn	NOUN
fnp-3049	318	37	that	that	PRON
fnp-3049	318	38	relies	rely	VERB
fnp-3049	318	39	on	on	ADP
fnp-3049	318	40	the	the	DET
fnp-3049	318	41	endogenous	endogenous	ADJ
fnp-3049	318	42	protein	protein	NOUN
fnp-3049	318	43	to	to	PART
fnp-3049	318	44	template	template	VERB
fnp-3049	318	45	and	and	CCONJ
fnp-3049	318	46	spread	spread	VERB
fnp-3049	318	47	via	via	ADP
fnp-3049	318	48	anatomically	anatomically	ADV
fnp-3049	318	49	connected	connect	VERB
fnp-3049	318	50	regions	region	NOUN
fnp-3049	318	51	.	.	PUNCT
fnp-3049	319	1	to	to	ADP
fnp-3049	319	2	date	date	NOUN
fnp-3049	319	3	,	,	PUNCT
fnp-3049	319	4	there	there	PRON
fnp-3049	319	5	are	be	VERB
fnp-3049	319	6	no	no	DET
fnp-3049	319	7	studies	study	NOUN
fnp-3049	319	8	that	that	PRON
fnp-3049	319	9	have	have	AUX
fnp-3049	319	10	directly	directly	ADV
fnp-3049	319	11	compared	compare	VERB
fnp-3049	319	12	the	the	DET
fnp-3049	319	13	assembly	assembly	NOUN
fnp-3049	319	14	states	state	NOUN
fnp-3049	319	15	of	of	ADP
fnp-3049	319	16	the	the	DET
fnp-3049	319	17	αsyn	αsyn	NOUN
fnp-3049	319	18	in	in	ADP
fnp-3049	319	19	the	the	DET
fnp-3049	319	20	intraneuronal	intraneuronal	ADJ
fnp-3049	319	21	inclusions	inclusion	NOUN
fnp-3049	319	22	that	that	PRON
fnp-3049	319	23	remain	remain	VERB
fnp-3049	319	24	after	after	ADP
fnp-3049	319	25	several	several	ADJ
fnp-3049	319	26	weeks	week	NOUN
fnp-3049	319	27	in	in	ADP
fnp-3049	319	28	an	an	DET
fnp-3049	319	29	overexpression	overexpression	NOUN
fnp-3049	319	30	versus	versus	ADP
fnp-3049	319	31	a	a	DET
fnp-3049	319	32	seeding	seeding	NOUN
fnp-3049	319	33	model	model	NOUN
fnp-3049	319	34	,	,	PUNCT
fnp-3049	319	35	but	but	CCONJ
fnp-3049	319	36	it	it	PRON
fnp-3049	319	37	appears	appear	VERB
fnp-3049	319	38	that	that	SCONJ
fnp-3049	319	39	inhibiting	inhibit	VERB
fnp-3049	319	40	the	the	DET
fnp-3049	319	41	mpc	mpc	NOUN
fnp-3049	319	42	has	have	VERB
fnp-3049	319	43	different	different	ADJ
fnp-3049	319	44	outcomes	outcome	NOUN
fnp-3049	319	45	in	in	ADP
fnp-3049	319	46	these	these	DET
fnp-3049	319	47	two	two	NUM
fnp-3049	319	48	models	model	NOUN
fnp-3049	319	49	.	.	PUNCT
fnp-3049	320	1	this	this	PRON
fnp-3049	320	2	tentatively	tentatively	ADV
fnp-3049	320	3	suggests	suggest	VERB
fnp-3049	320	4	i	i	PRON
fnp-3049	320	5	)	)	PUNCT
fnp-3049	320	6	that	that	SCONJ
fnp-3049	320	7	the	the	DET
fnp-3049	320	8	conformational	conformational	ADJ
fnp-3049	320	9	state	state	NOUN
fnp-3049	320	10	or	or	CCONJ
fnp-3049	320	11	aggregation	aggregation	NOUN
fnp-3049	320	12	state	state	NOUN
fnp-3049	320	13	of	of	ADP
fnp-3049	320	14	αsyn	αsyn	NOUN
fnp-3049	320	15	might	might	AUX
fnp-3049	320	16	be	be	AUX
fnp-3049	320	17	different	different	ADJ
fnp-3049	320	18	in	in	ADP
fnp-3049	320	19	the	the	DET
fnp-3049	320	20	two	two	NUM
fnp-3049	320	21	models	model	NOUN
fnp-3049	320	22	and	and	CCONJ
fnp-3049	320	23	ii	ii	NOUN
fnp-3049	320	24	)	)	PUNCT
fnp-3049	320	25	that	that	SCONJ
fnp-3049	320	26	the	the	DET
fnp-3049	320	27	effects	effect	NOUN
fnp-3049	320	28	of	of	ADP
fnp-3049	320	29	inhibiting	inhibit	VERB
fnp-3049	320	30	the	the	DET
fnp-3049	320	31	mpc	mpc	NOUN
fnp-3049	320	32	depends	depend	VERB
fnp-3049	320	33	on	on	ADP
fnp-3049	320	34	the	the	DET
fnp-3049	320	35	assembly	assembly	NOUN
fnp-3049	320	36	state	state	NOUN
fnp-3049	320	37	of	of	ADP
fnp-3049	320	38	the	the	DET
fnp-3049	320	39	protein	protein	NOUN
fnp-3049	320	40	.	.	PUNCT
fnp-3049	321	1	we	we	PRON
fnp-3049	321	2	observed	observe	VERB
fnp-3049	321	3	a	a	DET
fnp-3049	321	4	disparity	disparity	NOUN
fnp-3049	321	5	in	in	ADP
fnp-3049	321	6	αsyn	αsyn	PROPN
fnp-3049	321	7	assembly	assembly	NOUN
fnp-3049	321	8	states	state	NOUN
fnp-3049	321	9	between	between	ADP
fnp-3049	321	10	the	the	DET
fnp-3049	321	11	viral	viral	ADJ
fnp-3049	321	12	vector	vector	NOUN
fnp-3049	321	13	-	-	PUNCT
fnp-3049	321	14	based	base	VERB
fnp-3049	321	15	and	and	CCONJ
fnp-3049	321	16	the	the	DET
fnp-3049	321	17	seeding	seeding	NOUN
fnp-3049	321	18	model	model	NOUN
fnp-3049	321	19	in	in	ADP
fnp-3049	321	20	multiple	multiple	ADJ
fnp-3049	321	21	assays	assay	NOUN
fnp-3049	321	22	.	.	PUNCT
fnp-3049	322	1	first	first	ADV
fnp-3049	322	2	,	,	PUNCT
fnp-3049	322	3	we	we	PRON
fnp-3049	322	4	used	use	VERB
fnp-3049	322	5	detection	detection	NOUN
fnp-3049	322	6	of	of	ADP
fnp-3049	322	7	nitrated	nitrated	ADJ
fnp-3049	322	8	αsyn	αsyn	NOUN
fnp-3049	322	9	to	to	PART
fnp-3049	322	10	determine	determine	VERB
fnp-3049	322	11	that	that	SCONJ
fnp-3049	322	12	αsyn	αsyn	NOUN
fnp-3049	322	13	is	be	AUX
fnp-3049	322	14	oxidized	oxidize	VERB
fnp-3049	322	15	in	in	ADP
fnp-3049	322	16	the	the	DET
fnp-3049	322	17	viral	viral	ADJ
fnp-3049	322	18	vector	vector	NOUN
fnp-3049	322	19	-	-	PUNCT
fnp-3049	322	20	based	base	VERB
fnp-3049	322	21	model	model	NOUN
fnp-3049	322	22	.	.	PUNCT
fnp-3049	323	1	a	a	DET
fnp-3049	323	2	previous	previous	ADJ
fnp-3049	323	3	study	study	NOUN
fnp-3049	323	4	showed	show	VERB
fnp-3049	323	5	that	that	SCONJ
fnp-3049	323	6	αsyn	αsyn	NOUN
fnp-3049	323	7	can	can	AUX
fnp-3049	323	8	bind	bind	VERB
fnp-3049	323	9	directly	directly	ADV
fnp-3049	323	10	to	to	ADP
fnp-3049	323	11	the	the	DET
fnp-3049	323	12	mitochondrial	mitochondrial	ADJ
fnp-3049	323	13	import	import	NOUN
fnp-3049	323	14	protein	protein	NOUN
fnp-3049	323	15	tom20	tom20	NOUN
fnp-3049	323	16	,	,	PUNCT
fnp-3049	323	17	which	which	PRON
fnp-3049	323	18	leads	lead	VERB
fnp-3049	323	19	to	to	ADP
fnp-3049	323	20	increased	increase	VERB
fnp-3049	323	21	mitochondrial	mitochondrial	ADJ
fnp-3049	323	22	respiration	respiration	NOUN
fnp-3049	323	23	and	and	CCONJ
fnp-3049	323	24	ros	ros	PROPN
fnp-3049	323	25	production17	production17	PROPN
fnp-3049	323	26	.	.	PUNCT
fnp-3049	324	1	we	we	PRON
fnp-3049	324	2	now	now	ADV
fnp-3049	324	3	find	find	VERB
fnp-3049	324	4	that	that	PRON
fnp-3049	324	5	oxidized	oxidize	VERB
fnp-3049	324	6	αsyn	αsyn	ADJ
fnp-3049	324	7	species	specie	NOUN
fnp-3049	324	8	are	be	AUX
fnp-3049	324	9	abundant	abundant	ADJ
fnp-3049	324	10	in	in	ADP
fnp-3049	324	11	neurons	neuron	NOUN
fnp-3049	324	12	in	in	ADP
fnp-3049	324	13	the	the	DET
fnp-3049	324	14	viral	viral	ADJ
fnp-3049	324	15	vector	vector	NOUN
fnp-3049	324	16	model	model	NOUN
fnp-3049	324	17	,	,	PUNCT
fnp-3049	324	18	but	but	CCONJ
fnp-3049	324	19	undetectable	undetectable	ADJ
fnp-3049	324	20	in	in	ADP
fnp-3049	324	21	the	the	DET
fnp-3049	324	22	pff	pff	PROPN
fnp-3049	324	23	model	model	NOUN
fnp-3049	324	24	.	.	PUNCT
fnp-3049	325	1	we	we	PRON
fnp-3049	325	2	postulate	postulate	VERB
fnp-3049	325	3	that	that	SCONJ
fnp-3049	325	4	by	by	ADP
fnp-3049	325	5	altering	alter	VERB
fnp-3049	325	6	the	the	DET
fnp-3049	325	7	tca	tca	PROPN
fnp-3049	325	8	cycle	cycle	NOUN
fnp-3049	325	9	when	when	SCONJ
fnp-3049	325	10	treating	treat	VERB
fnp-3049	325	11	mice	mouse	NOUN
fnp-3049	325	12	overexpressing	overexpresse	VERB
fnp-3049	325	13	αsyn	αsyn	NOUN
fnp-3049	325	14	with	with	ADP
fnp-3049	325	15	msdc-0160	msdc-0160	ADJ
fnp-3049	325	16	,	,	PUNCT
fnp-3049	325	17	the	the	DET
fnp-3049	325	18	oxidation	oxidation	NOUN
fnp-3049	325	19	of	of	ADP
fnp-3049	325	20	αsyn	αsyn	NOUN
fnp-3049	325	21	is	be	AUX
fnp-3049	325	22	increased	increase	VERB
fnp-3049	325	23	.	.	PUNCT
fnp-3049	326	1	this	this	PRON
fnp-3049	326	2	suggests	suggest	VERB
fnp-3049	326	3	that	that	SCONJ
fnp-3049	326	4	alterations	alteration	NOUN
fnp-3049	326	5	in	in	ADP
fnp-3049	326	6	mitochondrial	mitochondrial	ADJ
fnp-3049	326	7	metabolism	metabolism	NOUN
fnp-3049	326	8	might	might	AUX
fnp-3049	326	9	post	post	VERB
fnp-3049	326	10	-	-	ADJ
fnp-3049	326	11	translationally	translationally	ADJ
fnp-3049	326	12	modify	modify	VERB
fnp-3049	326	13	αsyn	αsyn	NOUN
fnp-3049	326	14	and	and	CCONJ
fnp-3049	326	15	make	make	VERB
fnp-3049	326	16	it	it	PRON
fnp-3049	326	17	more	more	ADJ
fnp-3049	326	18	aggregation	aggregation	NOUN
fnp-3049	326	19	prone	prone	ADJ
fnp-3049	326	20	,	,	PUNCT
fnp-3049	326	21	when	when	SCONJ
fnp-3049	326	22	the	the	DET
fnp-3049	326	23	protein	protein	NOUN
fnp-3049	326	24	is	be	AUX
fnp-3049	326	25	highly	highly	ADV
fnp-3049	326	26	concentrated	concentrate	VERB
fnp-3049	326	27	even	even	ADV
fnp-3049	326	28	though	though	SCONJ
fnp-3049	326	29	it	it	PRON
fnp-3049	326	30	is	be	AUX
fnp-3049	326	31	not	not	PART
fnp-3049	326	32	known	know	VERB
fnp-3049	326	33	how	how	SCONJ
fnp-3049	326	34	exactly	exactly	ADV
fnp-3049	326	35	a	a	DET
fnp-3049	326	36	metabolic	metabolic	NOUN
fnp-3049	326	37	switch	switch	NOUN
fnp-3049	326	38	would	would	AUX
fnp-3049	326	39	take	take	VERB
fnp-3049	326	40	place	place	NOUN
fnp-3049	326	41	in	in	ADP
fnp-3049	326	42	αsyn	αsyn	NOUN
fnp-3049	326	43	overexpressing	overexpresse	VERB
fnp-3049	326	44	neurons	neuron	NOUN
fnp-3049	326	45	nor	nor	CCONJ
fnp-3049	326	46	how	how	SCONJ
fnp-3049	326	47	it	it	PRON
fnp-3049	326	48	would	would	AUX
fnp-3049	326	49	affect	affect	VERB
fnp-3049	326	50	αsyn	αsyn	ADJ
fnp-3049	326	51	aggregation	aggregation	NOUN
fnp-3049	326	52	during	during	ADP
fnp-3049	326	53	anaplerosis	anaplerosis	NOUN
fnp-3049	326	54	.	.	PUNCT
fnp-3049	327	1	furthermore	furthermore	ADV
fnp-3049	327	2	,	,	PUNCT
fnp-3049	327	3	we	we	PRON
fnp-3049	327	4	propose	propose	VERB
fnp-3049	327	5	that	that	SCONJ
fnp-3049	327	6	elevated	elevated	ADJ
fnp-3049	327	7	levels	level	NOUN
fnp-3049	327	8	of	of	ADP
fnp-3049	327	9	soluble	soluble	ADJ
fnp-3049	327	10	αsyn	αsyn	NOUN
fnp-3049	327	11	are	be	AUX
fnp-3049	327	12	required	require	VERB
fnp-3049	327	13	for	for	SCONJ
fnp-3049	327	14	these	these	DET
fnp-3049	327	15	changes	change	NOUN
fnp-3049	327	16	to	to	PART
fnp-3049	327	17	take	take	VERB
fnp-3049	327	18	place	place	NOUN
fnp-3049	327	19	,	,	PUNCT
fnp-3049	327	20	since	since	SCONJ
fnp-3049	327	21	we	we	PRON
fnp-3049	327	22	did	do	AUX
fnp-3049	327	23	not	not	PART
fnp-3049	327	24	observe	observe	VERB
fnp-3049	327	25	similar	similar	ADJ
fnp-3049	327	26	effects	effect	NOUN
fnp-3049	327	27	in	in	ADP
fnp-3049	327	28	the	the	DET
fnp-3049	327	29	pff	pff	NOUN
fnp-3049	327	30	seeding	seeding	NOUN
fnp-3049	327	31	model	model	NOUN
fnp-3049	327	32	where	where	SCONJ
fnp-3049	327	33	the	the	DET
fnp-3049	327	34	endogenous	endogenous	ADJ
fnp-3049	327	35	levels	level	NOUN
fnp-3049	327	36	of	of	ADP
fnp-3049	327	37	αsyn	αsyn	NOUN
fnp-3049	327	38	are	be	AUX
fnp-3049	327	39	normal	normal	ADJ
fnp-3049	327	40	and	and	CCONJ
fnp-3049	327	41	aggregates	aggregate	NOUN
fnp-3049	327	42	are	be	AUX
fnp-3049	327	43	formed	form	VERB
fnp-3049	327	44	via	via	ADP
fnp-3049	327	45	an	an	DET
fnp-3049	327	46	induced	induced	ADJ
fnp-3049	327	47	seeding	seeding	NOUN
fnp-3049	327	48	mechanism	mechanism	NOUN
fnp-3049	327	49	.	.	PUNCT
fnp-3049	328	1	since	since	SCONJ
fnp-3049	328	2	the	the	DET
fnp-3049	328	3	conformational	conformational	ADJ
fnp-3049	328	4	state	state	NOUN
fnp-3049	328	5	of	of	ADP
fnp-3049	328	6	αsyn	αsyn	NOUN
fnp-3049	328	7	is	be	AUX
fnp-3049	328	8	closely	closely	ADV
fnp-3049	328	9	linked	link	VERB
fnp-3049	328	10	to	to	ADP
fnp-3049	328	11	its	its	PRON
fnp-3049	328	12	function23	function23	NOUN
fnp-3049	328	13	,	,	PUNCT
fnp-3049	328	14	it	it	PRON
fnp-3049	328	15	is	be	AUX
fnp-3049	328	16	possible	possible	ADJ
fnp-3049	328	17	that	that	SCONJ
fnp-3049	328	18	elevated	elevated	ADJ
fnp-3049	328	19	levels	level	NOUN
fnp-3049	328	20	of	of	ADP
fnp-3049	328	21	monomeric	monomeric	ADJ
fnp-3049	328	22	αsyn	αsyn	NOUN
fnp-3049	328	23	lead	lead	NOUN
fnp-3049	328	24	to	to	ADP
fnp-3049	328	25	changes	change	NOUN
fnp-3049	328	26	in	in	ADP
fnp-3049	328	27	assembly	assembly	NOUN
fnp-3049	328	28	state	state	NOUN
fnp-3049	328	29	or	or	CCONJ
fnp-3049	328	30	gain	gain	NOUN
fnp-3049	328	31	of	of	ADP
fnp-3049	328	32	post	post	ADJ
fnp-3049	328	33	-	-	ADJ
fnp-3049	328	34	translational	translational	ADJ
fnp-3049	328	35	modifications	modification	NOUN
fnp-3049	328	36	resulting	result	VERB
fnp-3049	328	37	in	in	ADP
fnp-3049	328	38	an	an	DET
fnp-3049	328	39	aberrant	aberrant	ADJ
fnp-3049	328	40	interaction	interaction	NOUN
fnp-3049	328	41	with	with	ADP
fnp-3049	328	42	mitochondria	mitochondria	NOUN
fnp-3049	328	43	.	.	PUNCT
fnp-3049	329	1	the	the	DET
fnp-3049	329	2	binding	bind	VERB
fnp-3049	329	3	affinity	affinity	NOUN
fnp-3049	329	4	of	of	ADP
fnp-3049	329	5	αsyn	αsyn	NOUN
fnp-3049	329	6	is	be	AUX
fnp-3049	329	7	higher	high	ADJ
fnp-3049	329	8	for	for	ADP
fnp-3049	329	9	mitochondrial	mitochondrial	ADJ
fnp-3049	329	10	membranes	membrane	NOUN
fnp-3049	329	11	due	due	ADP
fnp-3049	329	12	to	to	ADP
fnp-3049	329	13	the	the	DET
fnp-3049	329	14	unique	unique	ADJ
fnp-3049	329	15	presence	presence	NOUN
fnp-3049	329	16	of	of	ADP
fnp-3049	329	17	cardiolipin	cardiolipin	NOUN
fnp-3049	329	18	in	in	ADP
fnp-3049	329	19	mitochondria18	mitochondria18	NOUN
fnp-3049	329	20	.	.	PUNCT
fnp-3049	330	1	lipid	lipid	NOUN
fnp-3049	330	2	interaction	interaction	NOUN
fnp-3049	330	3	is	be	AUX
fnp-3049	330	4	an	an	DET
fnp-3049	330	5	important	important	ADJ
fnp-3049	330	6	catalyst	catalyst	NOUN
fnp-3049	330	7	for	for	ADP
fnp-3049	330	8	soluble	soluble	ADJ
fnp-3049	330	9	αsyn	αsyn	NOUN
fnp-3049	330	10	to	to	PART
fnp-3049	330	11	convert	convert	VERB
fnp-3049	330	12	into	into	ADP
fnp-3049	330	13	aggregated	aggregate	VERB
fnp-3049	330	14	αsyn24	αsyn24	NOUN
fnp-3049	330	15	and	and	CCONJ
fnp-3049	330	16	this	this	DET
fnp-3049	330	17	conversion	conversion	NOUN
fnp-3049	330	18	has	have	AUX
fnp-3049	330	19	been	be	AUX
fnp-3049	330	20	reported	report	VERB
fnp-3049	330	21	to	to	PART
fnp-3049	330	22	lead	lead	VERB
fnp-3049	330	23	to	to	ADP
fnp-3049	330	24	release	release	NOUN
fnp-3049	330	25	of	of	ADP
fnp-3049	330	26	mitochondrial	mitochondrial	ADJ
fnp-3049	330	27	nitric	nitric	ADJ
fnp-3049	330	28	oxide	oxide	NOUN
fnp-3049	330	29	and	and	CCONJ
fnp-3049	330	30	increased	increase	VERB
fnp-3049	330	31	oxidative	oxidative	ADJ
fnp-3049	330	32	stress25	stress25	NOUN
fnp-3049	330	33	.	.	PUNCT
fnp-3049	331	1	αsyn	αsyn	PROPN
fnp-3049	331	2	can	can	AUX
fnp-3049	331	3	disrupt	disrupt	VERB
fnp-3049	331	4	membrane	membrane	NOUN
fnp-3049	331	5	integrity	integrity	NOUN
fnp-3049	331	6	and	and	CCONJ
fnp-3049	331	7	cause	cause	VERB
fnp-3049	331	8	mitochondrial	mitochondrial	ADJ
fnp-3049	331	9	damage	damage	NOUN
fnp-3049	331	10	and	and	CCONJ
fnp-3049	331	11	degeneration	degeneration	NOUN
fnp-3049	331	12	of	of	ADP
fnp-3049	331	13	dopaminergic	dopaminergic	ADJ
fnp-3049	331	14	neurons17,26	neurons17,26	NOUN
fnp-3049	331	15	.	.	PUNCT
fnp-3049	331	16	recombinant	recombinant	ADJ
fnp-3049	331	17	nitrated	nitrated	ADJ
fnp-3049	331	18	species	specie	NOUN
fnp-3049	331	19	of	of	ADP
fnp-3049	331	20	αsyn	αsyn	PROPN
fnp-3049	331	21	injected	inject	VERB
fnp-3049	331	22	in	in	ADP
fnp-3049	331	23	rat	rat	NOUN
fnp-3049	331	24	sn	sn	PROPN
fnp-3049	331	25	have	have	AUX
fnp-3049	331	26	been	be	AUX
fnp-3049	331	27	shown	show	VERB
fnp-3049	331	28	to	to	PART
fnp-3049	331	29	be	be	AUX
fnp-3049	331	30	more	more	ADV
fnp-3049	331	31	toxic	toxic	ADJ
fnp-3049	331	32	than	than	ADP
fnp-3049	331	33	unmodified	unmodified	ADJ
fnp-3049	331	34	αsyn27	αsyn27	NOUN
fnp-3049	331	35	.	.	PUNCT
fnp-3049	332	1	in	in	ADP
fnp-3049	332	2	msdc-0160	msdc-0160	ADJ
fnp-3049	332	3	treated	treat	VERB
fnp-3049	332	4	mice	mouse	NOUN
fnp-3049	332	5	,	,	PUNCT
fnp-3049	332	6	we	we	PRON
fnp-3049	332	7	did	do	AUX
fnp-3049	332	8	indeed	indeed	ADV
fnp-3049	332	9	observe	observe	VERB
fnp-3049	332	10	greater	great	ADJ
fnp-3049	332	11	loss	loss	NOUN
fnp-3049	332	12	of	of	ADP
fnp-3049	332	13	dopamine	dopamine	NOUN
fnp-3049	332	14	neurons	neuron	NOUN
fnp-3049	332	15	in	in	ADP
fnp-3049	332	16	the	the	DET
fnp-3049	332	17	anterior	anterior	ADJ
fnp-3049	332	18	portion	portion	NOUN
fnp-3049	332	19	of	of	ADP
fnp-3049	332	20	the	the	DET
fnp-3049	332	21	sn	sn	NOUN
fnp-3049	332	22	,	,	PUNCT
fnp-3049	332	23	which	which	PRON
fnp-3049	332	24	was	be	AUX
fnp-3049	332	25	the	the	DET
fnp-3049	332	26	region	region	NOUN
fnp-3049	332	27	where	where	SCONJ
fnp-3049	332	28	viral	viral	ADJ
fnp-3049	332	29	vector	vector	NOUN
fnp-3049	332	30	-	-	PUNCT
fnp-3049	332	31	mediated	mediate	VERB
fnp-3049	332	32	expression	expression	NOUN
fnp-3049	332	33	of	of	ADP
fnp-3049	332	34	αsyn	αsyn	NOUN
fnp-3049	332	35	was	be	AUX
fnp-3049	332	36	the	the	DET
fnp-3049	332	37	highest	high	ADJ
fnp-3049	332	38	.	.	PUNCT
fnp-3049	333	1	multiple	multiple	ADJ
fnp-3049	333	2	molecules	molecule	NOUN
fnp-3049	333	3	of	of	ADP
fnp-3049	333	4	nitrated	nitrated	ADJ
fnp-3049	333	5	αsyn	αsyn	NOUN
fnp-3049	333	6	have	have	AUX
fnp-3049	333	7	been	be	AUX
fnp-3049	333	8	shown	show	VERB
fnp-3049	333	9	to	to	PART
fnp-3049	333	10	form	form	VERB
fnp-3049	333	11	soluble	soluble	ADJ
fnp-3049	333	12	assemblies	assembly	NOUN
fnp-3049	333	13	that	that	PRON
fnp-3049	333	14	are	be	AUX
fnp-3049	333	15	off	off	ADP
fnp-3049	333	16	pathway	pathway	NOUN
fnp-3049	333	17	to	to	ADP
fnp-3049	333	18	aggregation	aggregation	NOUN
fnp-3049	333	19	and	and	CCONJ
fnp-3049	333	20	relatively	relatively	ADV
fnp-3049	333	21	unstructured28	unstructured28	ADJ
fnp-3049	333	22	.	.	PUNCT
fnp-3049	334	1	in	in	ADP
fnp-3049	334	2	order	order	NOUN
fnp-3049	334	3	to	to	PART
fnp-3049	334	4	determine	determine	VERB
fnp-3049	334	5	if	if	SCONJ
fnp-3049	334	6	structured	structure	VERB
fnp-3049	334	7	amyloid	amyloid	NOUN
fnp-3049	334	8	forms	form	NOUN
fnp-3049	334	9	of	of	ADP
fnp-3049	334	10	αsyn	αsyn	NOUN
fnp-3049	334	11	were	be	AUX
fnp-3049	334	12	present	present	ADJ
fnp-3049	334	13	in	in	ADP
fnp-3049	334	14	our	our	PRON
fnp-3049	334	15	animal	animal	NOUN
fnp-3049	334	16	models	model	NOUN
fnp-3049	334	17	,	,	PUNCT
fnp-3049	334	18	we	we	PRON
fnp-3049	334	19	used	use	VERB
fnp-3049	334	20	the	the	DET
fnp-3049	334	21	conformation	conformation	NOUN
fnp-3049	334	22	sensitive	sensitive	PROPN
fnp-3049	334	23	lco	lco	PROPN
fnp-3049	334	24	h	h	NOUN
fnp-3049	334	25	-	-	PUNCT
fnp-3049	334	26	ftaa	ftaa	ADJ
fnp-3049	334	27	probe29	probe29	VERB
fnp-3049	334	28	.	.	PUNCT
fnp-3049	335	1	lcos	lco	NOUN
fnp-3049	335	2	are	be	AUX
fnp-3049	335	3	amyloid	amyloid	NOUN
fnp-3049	335	4	-	-	PUNCT
fnp-3049	335	5	conformation	conformation	NOUN
fnp-3049	335	6	-	-	PUNCT
fnp-3049	335	7	specific	specific	ADJ
fnp-3049	335	8	dyes	dye	NOUN
fnp-3049	335	9	that	that	PRON
fnp-3049	335	10	specifically	specifically	ADV
fnp-3049	335	11	bind	bind	VERB
fnp-3049	335	12	to	to	AUX
fnp-3049	335	13	amyloid	amyloid	NOUN
fnp-3049	335	14	αsyn	αsyn	NOUN
fnp-3049	335	15	in	in	ADP
fnp-3049	335	16	brain	brain	NOUN
fnp-3049	335	17	tissue	tissue	NOUN
fnp-3049	335	18	and	and	CCONJ
fnp-3049	335	19	csf30	csf30	NOUN
fnp-3049	335	20	.	.	PUNCT
fnp-3049	336	1	a	a	DET
fnp-3049	336	2	positive	positive	ADJ
fnp-3049	336	3	signal	signal	NOUN
fnp-3049	336	4	therefore	therefore	ADV
fnp-3049	336	5	indicates	indicate	VERB
fnp-3049	336	6	the	the	DET
fnp-3049	336	7	presence	presence	NOUN
fnp-3049	336	8	of	of	ADP
fnp-3049	336	9	well	well	ADV
fnp-3049	336	10	-	-	PUNCT
fnp-3049	336	11	structured	structure	VERB
fnp-3049	336	12	,	,	PUNCT
fnp-3049	336	13	β	β	X
fnp-3049	336	14	-	-	ADJ
fnp-3049	336	15	sheet	sheet	ADJ
fnp-3049	336	16	rich	rich	ADJ
fnp-3049	336	17	aggregated	aggregate	VERB
fnp-3049	336	18	αsyn	αsyn	NOUN
fnp-3049	336	19	.	.	PUNCT
fnp-3049	337	1	in	in	ADP
fnp-3049	337	2	addition	addition	NOUN
fnp-3049	337	3	,	,	PUNCT
fnp-3049	337	4	h	h	NOUN
fnp-3049	337	5	-	-	PUNCT
fnp-3049	337	6	ftaa	ftaa	PROPN
fnp-3049	337	7	has	have	AUX
fnp-3049	337	8	been	be	AUX
fnp-3049	337	9	used	use	VERB
fnp-3049	337	10	to	to	PART
fnp-3049	337	11	distinguish	distinguish	VERB
fnp-3049	337	12	protein	protein	NOUN
fnp-3049	337	13	inclusion	inclusion	NOUN
fnp-3049	337	14	bodies	body	NOUN
fnp-3049	337	15	in	in	ADP
fnp-3049	337	16	sporadic	sporadic	ADJ
fnp-3049	337	17	inclusion	inclusion	NOUN
fnp-3049	337	18	body	body	NOUN
fnp-3049	337	19	myositis	myositis	NOUN
fnp-3049	337	20	(	(	PUNCT
fnp-3049	337	21	s	s	NOUN
fnp-3049	337	22	-	-	PUNCT
fnp-3049	337	23	ibm	ibm	PROPN
fnp-3049	337	24	)	)	PUNCT
fnp-3049	337	25	and	and	CCONJ
fnp-3049	337	26	liver	liver	NOUN
fnp-3049	337	27	diseases21	diseases21	NOUN
fnp-3049	337	28	.	.	PUNCT
fnp-3049	338	1	upon	upon	SCONJ
fnp-3049	338	2	treatment	treatment	NOUN
fnp-3049	338	3	with	with	ADP
fnp-3049	338	4	h	h	NOUN
fnp-3049	338	5	-	-	PUNCT
fnp-3049	338	6	ftaa	ftaa	ADJ
fnp-3049	338	7	,	,	PUNCT
fnp-3049	338	8	we	we	PRON
fnp-3049	338	9	observed	observe	VERB
fnp-3049	338	10	a	a	DET
fnp-3049	338	11	strong	strong	ADJ
fnp-3049	338	12	positive	positive	ADJ
fnp-3049	338	13	signal	signal	NOUN
fnp-3049	338	14	in	in	ADP
fnp-3049	338	15	the	the	DET
fnp-3049	338	16	aon	aon	PROPN
fnp-3049	338	17	of	of	ADP
fnp-3049	338	18	animals	animal	NOUN
fnp-3049	338	19	injected	inject	VERB
fnp-3049	338	20	with	with	ADP
fnp-3049	338	21	pffs	pff	NOUN
fnp-3049	338	22	but	but	CCONJ
fnp-3049	338	23	no	no	DET
fnp-3049	338	24	signal	signal	NOUN
fnp-3049	338	25	in	in	ADP
fnp-3049	338	26	the	the	DET
fnp-3049	338	27	snpc	snpc	NOUN
fnp-3049	338	28	of	of	ADP
fnp-3049	338	29	animals	animal	NOUN
fnp-3049	338	30	overexpressing	overexpresse	VERB
fnp-3049	338	31	αsyn	αsyn	NOUN
fnp-3049	338	32	following	follow	VERB
fnp-3049	338	33	viral	viral	ADJ
fnp-3049	338	34	vector	vector	NOUN
fnp-3049	338	35	injection	injection	NOUN
fnp-3049	338	36	.	.	PUNCT
fnp-3049	339	1	the	the	DET
fnp-3049	339	2	fluorescent	fluorescent	ADJ
fnp-3049	339	3	signal	signal	NOUN
fnp-3049	339	4	was	be	AUX
fnp-3049	339	5	localized	localize	VERB
fnp-3049	339	6	to	to	ADP
fnp-3049	339	7	neurons	neuron	NOUN
fnp-3049	339	8	and	and	CCONJ
fnp-3049	339	9	the	the	DET
fnp-3049	339	10	morphology	morphology	NOUN
fnp-3049	339	11	was	be	AUX
fnp-3049	339	12	lewy	lewy	ADJ
fnp-3049	339	13	body	body	NOUN
fnp-3049	339	14	-	-	PUNCT
fnp-3049	339	15	like	like	ADJ
fnp-3049	339	16	with	with	ADP
fnp-3049	339	17	aggresomal	aggresomal	ADJ
fnp-3049	339	18	structures	structure	NOUN
fnp-3049	339	19	that	that	PRON
fnp-3049	339	20	resembled	resemble	VERB
fnp-3049	339	21	the	the	DET
fnp-3049	339	22	intracellular	intracellular	ADJ
fnp-3049	339	23	distribution	distribution	NOUN
fnp-3049	339	24	we	we	PRON
fnp-3049	339	25	observed	observe	VERB
fnp-3049	339	26	when	when	SCONJ
fnp-3049	339	27	staining	stain	VERB
fnp-3049	339	28	for	for	ADP
fnp-3049	339	29	αsyn	αsyn	ADJ
fnp-3049	339	30	pser129	pser129	PROPN
fnp-3049	339	31	.	.	PUNCT
fnp-3049	340	1	this	this	PRON
fnp-3049	340	2	illustrates	illustrate	VERB
fnp-3049	340	3	that	that	SCONJ
fnp-3049	340	4	the	the	DET
fnp-3049	340	5	two	two	NUM
fnp-3049	340	6	αsyn	αsyn	NOUN
fnp-3049	340	7	animal	animal	NOUN
fnp-3049	340	8	models	model	NOUN
fnp-3049	340	9	also	also	ADV
fnp-3049	340	10	differ	differ	VERB
fnp-3049	340	11	in	in	ADP
fnp-3049	340	12	that	that	SCONJ
fnp-3049	340	13	the	the	DET
fnp-3049	340	14	αsyn	αsyn	PROPN
fnp-3049	340	15	assembly	assembly	NOUN
fnp-3049	340	16	states	state	NOUN
fnp-3049	340	17	in	in	ADP
fnp-3049	340	18	these	these	DET
fnp-3049	340	19	models	model	NOUN
fnp-3049	340	20	are	be	AUX
fnp-3049	340	21	distinct	distinct	ADJ
fnp-3049	340	22	.	.	PUNCT
fnp-3049	341	1	these	these	DET
fnp-3049	341	2	differences	difference	NOUN
fnp-3049	341	3	were	be	AUX
fnp-3049	341	4	recently	recently	ADV
fnp-3049	341	5	discussed	discuss	VERB
fnp-3049	341	6	by	by	ADP
fnp-3049	341	7	gómez	gómez	NOUN
fnp-3049	341	8	-	-	PUNCT
fnp-3049	341	9	benito	benito	PROPN
fnp-3049	341	10	and	and	CCONJ
fnp-3049	341	11	colleagues	colleague	NOUN
fnp-3049	341	12	;	;	PUNCT
fnp-3049	341	13	αsyn	αsyn	ADJ
fnp-3049	341	14	species	specie	NOUN
fnp-3049	341	15	from	from	ADP
fnp-3049	341	16	the	the	DET
fnp-3049	341	17	aav	aav	NOUN
fnp-3049	341	18	overexpression	overexpression	NOUN
fnp-3049	341	19	model	model	NOUN
fnp-3049	341	20	lack	lack	NOUN
fnp-3049	341	21	seeding	seed	VERB
fnp-3049	341	22	activity	activity	NOUN
fnp-3049	341	23	while	while	SCONJ
fnp-3049	341	24	the	the	DET
fnp-3049	341	25	pff	pff	PROPN
fnp-3049	341	26	model	model	NOUN
fnp-3049	341	27	recapitulates	recapitulate	VERB
fnp-3049	341	28	αsyn	αsyn	ADJ
fnp-3049	341	29	propagation	propagation	NOUN
fnp-3049	341	30	with	with	ADP
fnp-3049	341	31	the	the	DET
fnp-3049	341	32	accumulation	accumulation	NOUN
fnp-3049	341	33	of	of	ADP
fnp-3049	341	34	lewy	lewy	PROPN
fnp-3049	341	35	body	body	NOUN
fnp-3049	341	36	-	-	PUNCT
fnp-3049	341	37	like	like	ADJ
fnp-3049	341	38	structures31	structures31	NOUN
fnp-3049	341	39	.	.	PUNCT
fnp-3049	342	1	in	in	ADP
fnp-3049	342	2	summary	summary	NOUN
fnp-3049	342	3	,	,	PUNCT
fnp-3049	342	4	msdc-0160	msdc-0160	NOUN
fnp-3049	342	5	does	do	AUX
fnp-3049	342	6	not	not	PART
fnp-3049	342	7	reduce	reduce	VERB
fnp-3049	342	8	αsyn	αsyn	ADJ
fnp-3049	342	9	aggregation	aggregation	NOUN
fnp-3049	342	10	in	in	ADP
fnp-3049	342	11	the	the	DET
fnp-3049	342	12	model	model	NOUN
fnp-3049	342	13	where	where	SCONJ
fnp-3049	342	14	a	a	DET
fnp-3049	342	15	viral	viral	ADJ
fnp-3049	342	16	vector	vector	NOUN
fnp-3049	342	17	is	be	AUX
fnp-3049	342	18	used	use	VERB
fnp-3049	342	19	to	to	PART
fnp-3049	342	20	overexpress	overexpress	VERB
fnp-3049	342	21	the	the	DET
fnp-3049	342	22	protein	protein	NOUN
fnp-3049	342	23	in	in	ADP
fnp-3049	342	24	the	the	DET
fnp-3049	342	25	nigrostriatal	nigrostriatal	ADJ
fnp-3049	342	26	system	system	NOUN
fnp-3049	342	27	.	.	PUNCT
fnp-3049	343	1	on	on	ADP
fnp-3049	343	2	the	the	DET
fnp-3049	343	3	contrary	contrary	NOUN
fnp-3049	343	4	,	,	PUNCT
fnp-3049	343	5	the	the	DET
fnp-3049	343	6	inhibition	inhibition	NOUN
fnp-3049	343	7	of	of	ADP
fnp-3049	343	8	mpc	mpc	NOUN
fnp-3049	343	9	results	result	NOUN
fnp-3049	343	10	in	in	ADP
fnp-3049	343	11	a	a	DET
fnp-3049	343	12	slight	slight	ADJ
fnp-3049	343	13	increase	increase	NOUN
fnp-3049	343	14	in	in	ADP
fnp-3049	343	15	αsyn	αsyn	ADJ
fnp-3049	343	16	protein	protein	NOUN
fnp-3049	343	17	content	content	NOUN
fnp-3049	343	18	.	.	PUNCT
fnp-3049	344	1	in	in	ADP
fnp-3049	344	2	the	the	DET
fnp-3049	344	3	model	model	NOUN
fnp-3049	344	4	using	use	VERB
fnp-3049	344	5	injection	injection	NOUN
fnp-3049	344	6	of	of	ADP
fnp-3049	344	7	pffs	pff	NOUN
fnp-3049	344	8	to	to	PART
fnp-3049	344	9	trigger	trigger	VERB
fnp-3049	344	10	a	a	DET
fnp-3049	344	11	cascade	cascade	NOUN
fnp-3049	344	12	of	of	ADP
fnp-3049	344	13	αsyn	αsyn	NOUN
fnp-3049	344	14	aggregate	aggregate	ADJ
fnp-3049	344	15	propagation	propagation	NOUN
fnp-3049	344	16	in	in	ADP
fnp-3049	344	17	the	the	DET
fnp-3049	344	18	olfactory	olfactory	ADJ
fnp-3049	344	19	system	system	NOUN
fnp-3049	344	20	,	,	PUNCT
fnp-3049	344	21	msdc-0160	msdc-0160	NOUN
fnp-3049	344	22	exhibits	exhibit	VERB
fnp-3049	344	23	no	no	DET
fnp-3049	344	24	effect	effect	NOUN
fnp-3049	344	25	on	on	ADP
fnp-3049	344	26	the	the	DET
fnp-3049	344	27	progressive	progressive	ADJ
fnp-3049	344	28	development	development	NOUN
fnp-3049	344	29	of	of	ADP
fnp-3049	344	30	synucleinopathy	synucleinopathy	NOUN
fnp-3049	344	31	in	in	ADP
fnp-3049	344	32	the	the	DET
fnp-3049	344	33	olfactory	olfactory	ADJ
fnp-3049	344	34	system	system	NOUN
fnp-3049	344	35	.	.	PUNCT
fnp-3049	345	1	in	in	ADP
fnp-3049	345	2	experimental	experimental	ADJ
fnp-3049	345	3	paradigms	paradigm	NOUN
fnp-3049	345	4	that	that	PRON
fnp-3049	345	5	involve	involve	VERB
fnp-3049	345	6	more	more	ADJ
fnp-3049	345	7	acute	acute	ADJ
fnp-3049	345	8	neuroinflammation	neuroinflammation	NOUN
fnp-3049	345	9	,	,	PUNCT
fnp-3049	345	10	we	we	PRON
fnp-3049	345	11	previously	previously	ADV
fnp-3049	345	12	showed	show	VERB
fnp-3049	345	13	that	that	SCONJ
fnp-3049	345	14	msdc-0160	msdc-0160	NOUN
fnp-3049	345	15	alleviates	alleviate	VERB
fnp-3049	345	16	the	the	DET
fnp-3049	345	17	inflammatory	inflammatory	ADJ
fnp-3049	345	18	response	response	NOUN
fnp-3049	345	19	in	in	ADP
fnp-3049	345	20	vitro	vitro	X
fnp-3049	345	21	and	and	CCONJ
fnp-3049	345	22	in	in	ADP
fnp-3049	345	23	vivo10	vivo10	PROPN
fnp-3049	345	24	.	.	PUNCT
fnp-3049	346	1	however	however	ADV
fnp-3049	346	2	,	,	PUNCT
fnp-3049	346	3	in	in	ADP
fnp-3049	346	4	the	the	DET
fnp-3049	346	5	pff	pff	NOUN
fnp-3049	346	6	and	and	CCONJ
fnp-3049	346	7	viral	viral	ADJ
fnp-3049	346	8	vector	vector	NOUN
fnp-3049	346	9	αsyn	αsyn	NOUN
fnp-3049	346	10	models	model	NOUN
fnp-3049	346	11	,	,	PUNCT
fnp-3049	346	12	we	we	PRON
fnp-3049	346	13	did	do	AUX
fnp-3049	346	14	not	not	PART
fnp-3049	346	15	detect	detect	VERB
fnp-3049	346	16	changes	change	NOUN
fnp-3049	346	17	in	in	ADP
fnp-3049	346	18	inflammation	inflammation	NOUN
fnp-3049	346	19	or	or	CCONJ
fnp-3049	346	20	evidence	evidence	NOUN
fnp-3049	346	21	for	for	ADP
fnp-3049	346	22	autophagy	autophagy	ADJ
fnp-3049	346	23	deficits	deficit	NOUN
fnp-3049	346	24	at	at	ADP
fnp-3049	346	25	the	the	DET
fnp-3049	346	26	survival	survival	NOUN
fnp-3049	346	27	times	time	NOUN
fnp-3049	346	28	we	we	PRON
fnp-3049	346	29	studied	study	VERB
fnp-3049	346	30	.	.	PUNCT
fnp-3049	347	1	we	we	PRON
fnp-3049	347	2	conclude	conclude	VERB
fnp-3049	347	3	that	that	SCONJ
fnp-3049	347	4	attenuation	attenuation	NOUN
fnp-3049	347	5	of	of	ADP
fnp-3049	347	6	the	the	DET
fnp-3049	347	7	mpc	mpc	NOUN
fnp-3049	347	8	in	in	ADP
fnp-3049	347	9	rodent	rodent	ADJ
fnp-3049	347	10	models	model	NOUN
fnp-3049	347	11	that	that	PRON
fnp-3049	347	12	do	do	AUX
fnp-3049	347	13	not	not	PART
fnp-3049	347	14	exhibit	exhibit	VERB
fnp-3049	347	15	inflammation	inflammation	NOUN
fnp-3049	347	16	and	and	CCONJ
fnp-3049	347	17	limited	limited	ADJ
fnp-3049	347	18	autophagy	autophagy	NOUN
fnp-3049	347	19	does	do	AUX
fnp-3049	347	20	not	not	PART
fnp-3049	347	21	result	result	VERB
fnp-3049	347	22	in	in	ADP
fnp-3049	347	23	a	a	DET
fnp-3049	347	24	reduction	reduction	NOUN
fnp-3049	347	25	of	of	ADP
fnp-3049	347	26	introduced	introduce	VERB
fnp-3049	347	27	αsyn	αsyn	NOUN
fnp-3049	347	28	.	.	PUNCT
fnp-3049	348	1	acknowledgements	acknowledgement	NOUN
fnp-3049	348	2	research	research	NOUN
fnp-3049	348	3	reported	report	VERB
fnp-3049	348	4	in	in	ADP
fnp-3049	348	5	this	this	DET
fnp-3049	348	6	publication	publication	NOUN
fnp-3049	348	7	was	be	AUX
fnp-3049	348	8	supported	support	VERB
fnp-3049	348	9	by	by	ADP
fnp-3049	348	10	the	the	DET
fnp-3049	348	11	cure	cure	NOUN
fnp-3049	348	12	parkinson	parkinson	NOUN
fnp-3049	348	13	’s	’s	PART
fnp-3049	348	14	trust	trust	PROPN
fnp-3049	348	15	award	award	NOUN
fnp-3049	348	16	number	number	NOUN
fnp-3049	348	17	42	42	NUM
fnp-3049	348	18	-	-	PUNCT
fnp-3049	348	19	40384	40384	NUM
fnp-3049	348	20	-	-	SYM
fnp-3049	348	21	1	1	NUM
fnp-3049	348	22	(	(	PUNCT
fnp-3049	348	23	p.b	p.b	NOUN
fnp-3049	348	24	.	.	PROPN
fnp-3049	348	25	)	)	PUNCT
fnp-3049	348	26	.	.	PUNCT
fnp-3049	349	1	w.p	w.p	PROPN
fnp-3049	349	2	.	.	PROPN
fnp-3049	349	3	acknowledges	acknowledge	VERB
fnp-3049	349	4	a	a	DET
fnp-3049	349	5	post	post	ADJ
fnp-3049	349	6	-	-	ADJ
fnp-3049	349	7	doctoral	doctoral	ADJ
fnp-3049	349	8	fellowship	fellowship	NOUN
fnp-3049	349	9	from	from	ADP
fnp-3049	349	10	fulbright	fulbright	PROPN
fnp-3049	349	11	,	,	PUNCT
fnp-3049	349	12	idt	idt	ADJ
fnp-3049	349	13	technologies	technology	NOUN
fnp-3049	349	14	and	and	CCONJ
fnp-3049	349	15	fwo	fwo	ADP
fnp-3049	349	16	flanders	flander	NOUN
fnp-3049	349	17	.	.	PUNCT
fnp-3049	350	1	we	we	PRON
fnp-3049	350	2	thank	thank	VERB
fnp-3049	350	3	the	the	DET
fnp-3049	350	4	staff	staff	NOUN
fnp-3049	350	5	of	of	ADP
fnp-3049	350	6	the	the	DET
fnp-3049	350	7	vivarium	vivarium	NOUN
fnp-3049	350	8	of	of	ADP
fnp-3049	350	9	van	van	PROPN
fnp-3049	350	10	andel	andel	PROPN
fnp-3049	350	11	institute	institute	PROPN
fnp-3049	350	12	for	for	ADP
fnp-3049	350	13	caring	care	VERB
fnp-3049	350	14	for	for	ADP
fnp-3049	350	15	the	the	DET
fnp-3049	350	16	mice	mouse	NOUN
fnp-3049	350	17	and	and	CCONJ
fnp-3049	350	18	rats	rat	NOUN
fnp-3049	350	19	used	use	VERB
fnp-3049	350	20	in	in	ADP
fnp-3049	350	21	this	this	DET
fnp-3049	350	22	study	study	NOUN
fnp-3049	350	23	.	.	PUNCT
fnp-3049	351	1	author	author	NOUN
fnp-3049	351	2	contributions	contribution	NOUN
fnp-3049	351	3	w.p	w.p	PROPN
fnp-3049	351	4	.	.	PROPN
fnp-3049	351	5	performed	perform	VERB
fnp-3049	351	6	rat	rat	NOUN
fnp-3049	351	7	studies	study	NOUN
fnp-3049	351	8	(	(	PUNCT
fnp-3049	351	9	stereotaxic	stereotaxic	ADJ
fnp-3049	351	10	surgery	surgery	NOUN
fnp-3049	351	11	and	and	CCONJ
fnp-3049	351	12	behavioral	behavioral	ADJ
fnp-3049	351	13	,	,	PUNCT
fnp-3049	351	14	biochemical	biochemical	ADJ
fnp-3049	351	15	and	and	CCONJ
fnp-3049	351	16	immunohistochemical	immunohistochemical	ADJ
fnp-3049	351	17	analysis	analysis	NOUN
fnp-3049	351	18	)	)	PUNCT
fnp-3049	351	19	and	and	CCONJ
fnp-3049	351	20	wrote	write	VERB
fnp-3049	351	21	the	the	DET
fnp-3049	351	22	manuscript	manuscript	NOUN
fnp-3049	351	23	.	.	PUNCT
fnp-3049	352	1	l.b	l.b	PROPN
fnp-3049	352	2	.	.	PROPN
fnp-3049	352	3	performed	perform	VERB
fnp-3049	352	4	mouse	mouse	NOUN
fnp-3049	352	5	olfactory	olfactory	NOUN
fnp-3049	352	6	testing	testing	NOUN
fnp-3049	352	7	,	,	PUNCT
fnp-3049	352	8	neun	neun	NOUN
fnp-3049	352	9	immunostaining	immunostaining	NOUN
fnp-3049	352	10	and	and	CCONJ
fnp-3049	352	11	stereology	stereology	NOUN
fnp-3049	352	12	,	,	PUNCT
fnp-3049	352	13	pser129	pser129	PROPN
fnp-3049	352	14	immunostaining	immunostaining	NOUN
fnp-3049	352	15	and	and	CCONJ
fnp-3049	352	16	analysis	analysis	NOUN
fnp-3049	352	17	,	,	PUNCT
fnp-3049	352	18	ni	ni	NOUN
fnp-3049	352	19	-	-	ADJ
fnp-3049	352	20	αsyn	αsyn	PROPN
fnp-3049	352	21	staining	staining	NOUN
fnp-3049	352	22	,	,	PUNCT
fnp-3049	352	23	lamp2	lamp2	NOUN
fnp-3049	352	24	immunostaining	immunostaining	NOUN
fnp-3049	352	25	and	and	CCONJ
fnp-3049	352	26	analysis	analysis	NOUN
fnp-3049	352	27	,	,	PUNCT
fnp-3049	352	28	iba-1	iba-1	ADV
fnp-3049	352	29	immunostaining	immunostaine	VERB
fnp-3049	352	30	and	and	CCONJ
fnp-3049	352	31	analysis	analysis	NOUN
fnp-3049	352	32	,	,	PUNCT
fnp-3049	352	33	h	h	NOUN
fnp-3049	352	34	-	-	PUNCT
fnp-3049	352	35	ftaa	ftaa	ADJ
fnp-3049	352	36	/	/	SYM
fnp-3049	352	37	pser129	pser129	PROPN
fnp-3049	352	38	co	co	VERB
fnp-3049	352	39	-	-	VERB
fnp-3049	352	40	immunostaining	immunostaine	VERB
fnp-3049	352	41	and	and	CCONJ
fnp-3049	352	42	imaging	imaging	NOUN
fnp-3049	352	43	and	and	CCONJ
fnp-3049	352	44	wrote	write	VERB
fnp-3049	352	45	the	the	DET
fnp-3049	352	46	manuscript	manuscript	NOUN
fnp-3049	352	47	.	.	PUNCT
fnp-3049	353	1	s.g	s.g	PROPN
fnp-3049	353	2	.	.	PROPN
fnp-3049	353	3	performed	perform	VERB
fnp-3049	353	4	pilot	pilot	NOUN
fnp-3049	353	5	studies	study	NOUN
fnp-3049	353	6	leading	lead	VERB
fnp-3049	353	7	to	to	ADP
fnp-3049	353	8	the	the	DET
fnp-3049	353	9	final	final	ADJ
fnp-3049	353	10	conceptualization	conceptualization	NOUN
fnp-3049	353	11	of	of	ADP
fnp-3049	353	12	the	the	DET
fnp-3049	353	13	aav	aav	NOUN
fnp-3049	353	14	overexpression	overexpression	NOUN
fnp-3049	353	15	model	model	NOUN
fnp-3049	353	16	study	study	NOUN
fnp-3049	353	17	.	.	PUNCT
fnp-3049	354	1	m.e.j	m.e.j	PROPN
fnp-3049	354	2	.	.	PROPN
fnp-3049	355	1	performed	perform	VERB
fnp-3049	355	2	pser129	pser129	PROPN
fnp-3049	355	3	immunostaining	immunostaine	VERB
fnp-3049	355	4	.	.	PUNCT
fnp-3049	356	1	j.s	j.s	PROPN
fnp-3049	356	2	.	.	PROPN
fnp-3049	356	3	organized	organize	VERB
fnp-3049	356	4	the	the	DET
fnp-3049	356	5	manufacturing	manufacturing	NOUN
fnp-3049	356	6	of	of	ADP
fnp-3049	356	7	the	the	DET
fnp-3049	356	8	msdc-0160	msdc-0160	ADJ
fnp-3049	356	9	chow	chow	NOUN
fnp-3049	356	10	,	,	PUNCT
fnp-3049	356	11	metabolic	metabolic	NOUN
fnp-3049	356	12	detection	detection	NOUN
fnp-3049	356	13	,	,	PUNCT
fnp-3049	356	14	plasma	plasma	NOUN
fnp-3049	356	15	,	,	PUNCT
fnp-3049	356	16	csf	csf	NOUN
fnp-3049	356	17	and	and	CCONJ
fnp-3049	356	18	brain	brain	NOUN
fnp-3049	356	19	mitochondria	mitochondria	NOUN
fnp-3049	356	20	collection	collection	NOUN
fnp-3049	356	21	and	and	CCONJ
fnp-3049	356	22	provided	provide	VERB
fnp-3049	356	23	advice	advice	NOUN
fnp-3049	356	24	.	.	PUNCT
fnp-3049	357	1	l.m	l.m	PROPN
fnp-3049	357	2	.	.	PROPN
fnp-3049	357	3	performed	perform	VERB
fnp-3049	357	4	unilateral	unilateral	ADJ
fnp-3049	357	5	pff	pff	NOUN
fnp-3049	357	6	surgery	surgery	NOUN
fnp-3049	357	7	,	,	PUNCT
fnp-3049	357	8	mouse	mouse	NOUN
fnp-3049	357	9	perfusions	perfusion	NOUN
fnp-3049	357	10	and	and	CCONJ
fnp-3049	357	11	plasma	plasma	NOUN
fnp-3049	357	12	,	,	PUNCT
fnp-3049	357	13	csf	csf	NOUN
fnp-3049	357	14	and	and	CCONJ
fnp-3049	357	15	brain	brain	NOUN
fnp-3049	357	16	mitochondria	mitochondria	PROPN
fnp-3049	357	17	collection	collection	PROPN
fnp-3049	357	18	.	.	PUNCT
fnp-3049	358	1	e.s	e.s	PROPN
fnp-3049	358	2	.	.	PROPN
fnp-3049	358	3	performed	perform	VERB
fnp-3049	358	4	unilateral	unilateral	ADJ
fnp-3049	358	5	pff	pff	NOUN
fnp-3049	358	6	surgery	surgery	NOUN
fnp-3049	358	7	,	,	PUNCT
fnp-3049	358	8	mouse	mouse	NOUN
fnp-3049	358	9	perfusions	perfusion	NOUN
fnp-3049	358	10	,	,	PUNCT
fnp-3049	358	11	plasma	plasma	NOUN
fnp-3049	358	12	,	,	PUNCT
fnp-3049	358	13	csf	csf	NOUN
fnp-3049	358	14	and	and	CCONJ
fnp-3049	358	15	brain	brain	NOUN
fnp-3049	358	16	mitochondria	mitochondria	NOUN
fnp-3049	358	17	collection	collection	PROPN
fnp-3049	358	18	and	and	CCONJ
fnp-3049	358	19	ni	ni	PROPN
fnp-3049	358	20	-	-	ADJ
fnp-3049	358	21	αsyn	αsyn	ADJ
fnp-3049	358	22	staining	stain	VERB
fnp-3049	358	23	optimization	optimization	NOUN
fnp-3049	358	24	.	.	PUNCT
fnp-3049	359	1	z.m	z.m	PROPN
fnp-3049	359	2	.	.	PROPN
fnp-3049	359	3	performed	perform	VERB
fnp-3049	359	4	the	the	DET
fnp-3049	359	5	statistical	statistical	ADJ
fnp-3049	359	6	analysis	analysis	NOUN
fnp-3049	359	7	.	.	PUNCT
fnp-3049	360	1	j.m	j.m	PROPN
fnp-3049	360	2	.	.	PROPN
fnp-3049	360	3	provided	provide	VERB
fnp-3049	360	4	the	the	DET
fnp-3049	360	5	pffs	pff	NOUN
fnp-3049	360	6	.	.	PUNCT
fnp-3049	361	1	k.b	k.b	PROPN
fnp-3049	361	2	.	.	PROPN
fnp-3049	361	3	performed	perform	VERB
fnp-3049	361	4	pff	pff	PROPN
fnp-3049	361	5	manufacturing	manufacturing	NOUN
fnp-3049	361	6	.	.	PUNCT
fnp-3049	362	1	j.r.c	j.r.c	NOUN
fnp-3049	362	2	.	.	PUNCT
fnp-3049	362	3	provided	provide	VERB
fnp-3049	362	4	the	the	DET
fnp-3049	362	5	compound	compound	NOUN
fnp-3049	362	6	(	(	PUNCT
fnp-3049	362	7	msdc-0160	msdc-0160	ADJ
fnp-3049	362	8	)	)	PUNCT
fnp-3049	362	9	,	,	PUNCT
fnp-3049	362	10	expertise	expertise	NOUN
fnp-3049	362	11	and	and	CCONJ
fnp-3049	362	12	advice	advice	NOUN
fnp-3049	362	13	.	.	PUNCT
fnp-3049	363	1	p.b	p.b	PROPN
fnp-3049	363	2	.	.	PROPN
fnp-3049	363	3	conceptualized	conceptualize	VERB
fnp-3049	363	4	this	this	DET
fnp-3049	363	5	study	study	NOUN
fnp-3049	363	6	and	and	CCONJ
fnp-3049	363	7	provided	provide	VERB
fnp-3049	363	8	expertise	expertise	NOUN
fnp-3049	363	9	and	and	CCONJ
fnp-3049	363	10	advice	advice	NOUN
fnp-3049	363	11	.	.	PUNCT
fnp-3049	364	1	all	all	DET
fnp-3049	364	2	authors	author	NOUN
fnp-3049	364	3	reviewed	review	VERB
fnp-3049	364	4	and	and	CCONJ
fnp-3049	364	5	edited	edit	VERB
fnp-3049	364	6	the	the	DET
fnp-3049	364	7	manuscript	manuscript	NOUN
fnp-3049	364	8	.	.	PUNCT
fnp-3049	365	1	disclosure	disclosure	NOUN
fnp-3049	365	2	p.b	p.b	PROPN
fnp-3049	365	3	.	.	PROPN
fnp-3049	365	4	receives	receive	VERB
fnp-3049	365	5	commercial	commercial	ADJ
fnp-3049	365	6	support	support	NOUN
fnp-3049	365	7	as	as	ADP
fnp-3049	365	8	a	a	DET
fnp-3049	365	9	consultant	consultant	NOUN
fnp-3049	365	10	from	from	ADP
fnp-3049	365	11	calico	calico	PROPN
fnp-3049	365	12	life	life	NOUN
fnp-3049	365	13	sciences	science	NOUN
fnp-3049	365	14	,	,	PUNCT
fnp-3049	365	15	curasen	curasen	PROPN
fnp-3049	365	16	,	,	PUNCT
fnp-3049	365	17	idorsia	idorsia	PROPN
fnp-3049	365	18	pharmaceuticals	pharmaceutical	NOUN
fnp-3049	365	19	,	,	PUNCT
fnp-3049	365	20	lundbeck	lundbeck	NOUN
fnp-3049	365	21	a	a	PROPN
fnp-3049	365	22	/	/	SYM
fnp-3049	365	23	s	s	PROPN
fnp-3049	365	24	,	,	PUNCT
fnp-3049	365	25	abbvie	abbvie	NOUN
fnp-3049	365	26	,	,	PUNCT
fnp-3049	365	27	fujifilm	fujifilm	NOUN
fnp-3049	365	28	-	-	PUNCT
fnp-3049	365	29	cellular	cellular	ADJ
fnp-3049	365	30	dynamics	dynamic	NOUN
fnp-3049	365	31	international	international	ADJ
fnp-3049	365	32	,	,	PUNCT
fnp-3049	365	33	and	and	CCONJ
fnp-3049	365	34	axial	axial	ADJ
fnp-3049	365	35	biotherapeutics	biotherapeutic	NOUN
fnp-3049	365	36	.	.	PUNCT
fnp-3049	366	1	he	he	PRON
fnp-3049	366	2	has	have	AUX
fnp-3049	366	3	received	receive	VERB
fnp-3049	366	4	commercial	commercial	ADJ
fnp-3049	366	5	support	support	NOUN
fnp-3049	366	6	for	for	ADP
fnp-3049	366	7	research	research	NOUN
fnp-3049	366	8	from	from	ADP
fnp-3049	366	9	lundbeck	lundbeck	PROPN
fnp-3049	366	10	a	a	PROPN
fnp-3049	366	11	/	/	SYM
fnp-3049	366	12	s	s	NOUN
fnp-3049	366	13	and	and	CCONJ
fnp-3049	366	14	roche	roche	NOUN
fnp-3049	366	15	.	.	PUNCT
fnp-3049	367	1	he	he	PRON
fnp-3049	367	2	has	have	VERB
fnp-3049	367	3	ownership	ownership	NOUN
fnp-3049	367	4	interests	interest	NOUN
fnp-3049	367	5	in	in	ADP
fnp-3049	367	6	acousort	acousort	PROPN
fnp-3049	367	7	ab	ab	PROPN
fnp-3049	367	8	.	.	PROPN
fnp-3049	367	9	j.r.c	j.r.c	PROPN
fnp-3049	367	10	.	.	PUNCT
fnp-3049	368	1	is	be	AUX
fnp-3049	368	2	the	the	DET
fnp-3049	368	3	cofounder	cofounder	NOUN
fnp-3049	368	4	and	and	CCONJ
fnp-3049	368	5	significant	significant	ADJ
fnp-3049	368	6	owner	owner	NOUN
fnp-3049	368	7	of	of	ADP
fnp-3049	368	8	metabolic	metabolic	NOUN
fnp-3049	368	9	solutions	solution	NOUN
fnp-3049	368	10	development	development	NOUN
fnp-3049	368	11	company	company	NOUN
fnp-3049	368	12	(	(	PUNCT
fnp-3049	368	13	msdc	msdc	PROPN
fnp-3049	368	14	)	)	PUNCT
fnp-3049	368	15	,	,	PUNCT
fnp-3049	368	16	which	which	PRON
fnp-3049	368	17	is	be	AUX
fnp-3049	368	18	currently	currently	ADV
fnp-3049	368	19	developing	develop	VERB
fnp-3049	368	20	msdc-0160	msdc-0160	ADJ
fnp-3049	368	21	as	as	ADP
fnp-3049	368	22	a	a	DET
fnp-3049	368	23	potential	potential	ADJ
fnp-3049	368	24	treatment	treatment	NOUN
fnp-3049	368	25	for	for	ADP
fnp-3049	368	26	alzheimer	alzheimer	PROPN
fnp-3049	368	27	’s	’s	PART
fnp-3049	368	28	disease	disease	NOUN
fnp-3049	368	29	.	.	PUNCT
fnp-3049	369	1	msdc-0160	msdc-0160	ADJ
fnp-3049	369	2	is	be	AUX
fnp-3049	369	3	protected	protect	VERB
fnp-3049	369	4	by	by	ADP
fnp-3049	369	5	several	several	ADJ
fnp-3049	369	6	patents	patent	NOUN
fnp-3049	369	7	,	,	PUNCT
fnp-3049	369	8	including	include	VERB
fnp-3049	369	9	us	we	PRON
fnp-3049	369	10	8389556	8389556	NUM
fnp-3049	369	11	b2	b2	NOUN
fnp-3049	369	12	and	and	CCONJ
fnp-3049	369	13	ep	ep	PROPN
fnp-3049	369	14	2001468	2001468	NUM
fnp-3049	369	15	b1	b1	PROPN
fnp-3049	369	16	,	,	PUNCT
fnp-3049	369	17	which	which	PRON
fnp-3049	369	18	are	be	AUX
fnp-3049	369	19	assigned	assign	VERB
fnp-3049	369	20	to	to	ADP
fnp-3049	369	21	msdc	msdc	PROPN
fnp-3049	369	22	.	.	PUNCT
fnp-3049	370	1	all	all	DET
fnp-3049	370	2	other	other	ADJ
fnp-3049	370	3	authors	author	NOUN
fnp-3049	370	4	declare	declare	VERB
fnp-3049	370	5	no	no	DET
fnp-3049	370	6	additional	additional	ADJ
fnp-3049	370	7	competing	compete	VERB
fnp-3049	370	8	financial	financial	ADJ
fnp-3049	370	9	interests	interest	NOUN
fnp-3049	370	10	.	.	PUNCT
fnp-3049	371	1	references	reference	NOUN
fnp-3049	371	2	1	1	NUM
fnp-3049	371	3	.	.	PUNCT
fnp-3049	371	4	stern	stern	ADJ
fnp-3049	371	5	,	,	PUNCT
fnp-3049	371	6	m.	m.	PROPN
fnp-3049	371	7	b.	b.	PROPN
fnp-3049	371	8	,	,	PUNCT
fnp-3049	371	9	lang	lang	PROPN
fnp-3049	371	10	,	,	PUNCT
fnp-3049	371	11	a.	a.	PROPN
fnp-3049	371	12	&	&	CCONJ
fnp-3049	371	13	poewe	poewe	PROPN
fnp-3049	371	14	,	,	PUNCT
fnp-3049	371	15	w.	w.	NOUN
fnp-3049	371	16	toward	toward	ADP
fnp-3049	371	17	a	a	DET
fnp-3049	371	18	redefinition	redefinition	NOUN
fnp-3049	371	19	of	of	ADP
fnp-3049	371	20	parkinson	parkinson	NOUN
fnp-3049	371	21	's	's	PART
fnp-3049	371	22	disease	disease	NOUN
fnp-3049	371	23	.	.	PUNCT
fnp-3049	372	1	mov	mov	NOUN
fnp-3049	372	2	disord	disord	NOUN
fnp-3049	372	3	.	.	PUNCT
fnp-3049	373	1	27	27	NUM
fnp-3049	373	2	,	,	PUNCT
fnp-3049	373	3	54–60	54–60	NUM
fnp-3049	373	4	(	(	PUNCT
fnp-3049	373	5	2012	2012	NUM
fnp-3049	373	6	)	)	PUNCT
fnp-3049	373	7	.	.	PUNCT
fnp-3049	374	1	2	2	X
fnp-3049	374	2	.	.	X
fnp-3049	374	3	park	park	NOUN
fnp-3049	374	4	,	,	PUNCT
fnp-3049	374	5	j.-s	j.-s	PROPN
fnp-3049	374	6	.	.	PUNCT
fnp-3049	374	7	,	,	PUNCT
fnp-3049	374	8	davis	davis	PROPN
fnp-3049	374	9	,	,	PUNCT
fnp-3049	374	10	r.	r.	PROPN
fnp-3049	374	11	l.	l.	PROPN
fnp-3049	374	12	&	&	CCONJ
fnp-3049	374	13	sue	sue	PROPN
fnp-3049	374	14	,	,	PUNCT
fnp-3049	374	15	c.	c.	PROPN
fnp-3049	374	16	m.	m.	NOUN
fnp-3049	374	17	mitochondrial	mitochondrial	ADJ
fnp-3049	374	18	dysfunction	dysfunction	NOUN
fnp-3049	374	19	in	in	ADP
fnp-3049	374	20	parkinson	parkinson	NOUN
fnp-3049	374	21	’s	’s	PART
fnp-3049	374	22	disease	disease	NOUN
fnp-3049	374	23	:	:	PUNCT
fnp-3049	374	24	new	new	ADJ
fnp-3049	374	25	mechanistic	mechanistic	ADJ
fnp-3049	374	26	insights	insight	NOUN
fnp-3049	374	27	and	and	CCONJ
fnp-3049	374	28	therapeutic	therapeutic	ADJ
fnp-3049	374	29	perspectives	perspective	NOUN
fnp-3049	374	30	.	.	PUNCT
fnp-3049	375	1	1–11	1–11	PROPN
fnp-3049	375	2	(	(	PUNCT
fnp-3049	375	3	2018	2018	NUM
fnp-3049	375	4	)	)	PUNCT
fnp-3049	375	5	.	.	PUNCT
fnp-3049	376	1	doi:10.1007	doi:10.1007	VERB
fnp-3049	376	2	/	/	SYM
fnp-3049	376	3	s11910	s11910	PROPN
fnp-3049	376	4	-	-	PUNCT
fnp-3049	376	5	018	018	NUM
fnp-3049	376	6	-	-	PUNCT
fnp-3049	376	7	0829	0829	NUM
fnp-3049	376	8	-	-	PUNCT
fnp-3049	376	9	3	3	NUM
fnp-3049	376	10	3	3	NUM
fnp-3049	376	11	.	.	PUNCT
fnp-3049	376	12	brakedal	brakedal	NOUN
fnp-3049	376	13	,	,	PUNCT
fnp-3049	376	14	b.	b.	PROPN
fnp-3049	376	15	et	et	PROPN
fnp-3049	377	1	al	al	PROPN
fnp-3049	377	2	.	.	PROPN
fnp-3049	377	3	glitazone	glitazone	NOUN
fnp-3049	377	4	use	use	NOUN
fnp-3049	377	5	associated	associate	VERB
fnp-3049	377	6	with	with	ADP
fnp-3049	377	7	reduced	reduced	ADJ
fnp-3049	377	8	risk	risk	NOUN
fnp-3049	377	9	of	of	ADP
fnp-3049	377	10	parkinson	parkinson	NOUN
fnp-3049	377	11	's	's	PART
fnp-3049	377	12	disease	disease	NOUN
fnp-3049	377	13	.	.	PUNCT
fnp-3049	378	1	mov	mov	NOUN
fnp-3049	378	2	disord	disord	NOUN
fnp-3049	378	3	.	.	PUNCT
fnp-3049	379	1	54	54	NUM
fnp-3049	379	2	,	,	PUNCT
fnp-3049	379	3	s21–6	s21–6	PROPN
fnp-3049	379	4	(	(	PUNCT
fnp-3049	379	5	2017	2017	NUM
fnp-3049	379	6	)	)	PUNCT
fnp-3049	379	7	.	.	PUNCT
fnp-3049	380	1	4	4	X
fnp-3049	380	2	.	.	X
fnp-3049	380	3	brauer	brauer	PROPN
fnp-3049	380	4	,	,	PUNCT
fnp-3049	380	5	r.	r.	PROPN
fnp-3049	380	6	et	et	PROPN
fnp-3049	380	7	al	al	PROPN
fnp-3049	380	8	.	.	PROPN
fnp-3049	380	9	glitazone	glitazone	VERB
fnp-3049	380	10	treatment	treatment	NOUN
fnp-3049	380	11	and	and	CCONJ
fnp-3049	380	12	incidence	incidence	NOUN
fnp-3049	380	13	of	of	ADP
fnp-3049	380	14	parkinson	parkinson	NOUN
fnp-3049	380	15	’s	’s	PART
fnp-3049	380	16	disease	disease	NOUN
fnp-3049	380	17	among	among	ADP
fnp-3049	380	18	people	people	NOUN
fnp-3049	380	19	with	with	ADP
fnp-3049	380	20	diabetes	diabetes	NOUN
fnp-3049	380	21	:	:	PUNCT
fnp-3049	380	22	a	a	DET
fnp-3049	380	23	retrospective	retrospective	ADJ
fnp-3049	380	24	cohort	cohort	NOUN
fnp-3049	380	25	study	study	NOUN
fnp-3049	380	26	.	.	PUNCT
fnp-3049	381	1	plos	plos	PROPN
fnp-3049	381	2	med	med	PROPN
fnp-3049	381	3	12	12	NUM
fnp-3049	381	4	,	,	PUNCT
fnp-3049	381	5	e1001854–16	e1001854–16	NOUN
fnp-3049	381	6	(	(	PUNCT
fnp-3049	381	7	2015	2015	NUM
fnp-3049	381	8	)	)	PUNCT
fnp-3049	381	9	.	.	PUNCT
fnp-3049	382	1	5	5	X
fnp-3049	382	2	.	.	X
fnp-3049	382	3	biosa	biosa	PROPN
fnp-3049	382	4	,	,	PUNCT
fnp-3049	382	5	a.	a.	NOUN
fnp-3049	382	6	,	,	PUNCT
fnp-3049	382	7	outeiro	outeiro	ADJ
fnp-3049	382	8	,	,	PUNCT
fnp-3049	382	9	t.	t.	PROPN
fnp-3049	382	10	f.	f.	PROPN
fnp-3049	382	11	,	,	PUNCT
fnp-3049	382	12	bubacco	bubacco	PROPN
fnp-3049	382	13	,	,	PUNCT
fnp-3049	382	14	l.	l.	PROPN
fnp-3049	382	15	&	&	CCONJ
fnp-3049	382	16	bisaglia	bisaglia	PROPN
fnp-3049	382	17	,	,	PUNCT
fnp-3049	382	18	m.	m.	NOUN
fnp-3049	382	19	diabetes	diabetes	NOUN
fnp-3049	382	20	mellitus	mellitus	NOUN
fnp-3049	382	21	as	as	ADP
fnp-3049	382	22	a	a	DET
fnp-3049	382	23	risk	risk	NOUN
fnp-3049	382	24	factor	factor	NOUN
fnp-3049	382	25	for	for	ADP
fnp-3049	382	26	parkinson	parkinson	NOUN
fnp-3049	382	27	’s	’s	PART
fnp-3049	382	28	disease	disease	NOUN
fnp-3049	382	29	:	:	PUNCT
fnp-3049	382	30	a	a	DET
fnp-3049	382	31	molecular	molecular	ADJ
fnp-3049	382	32	point	point	NOUN
fnp-3049	382	33	of	of	ADP
fnp-3049	382	34	view	view	NOUN
fnp-3049	382	35	.	.	PUNCT
fnp-3049	383	1	1–10	1–10	NOUN
fnp-3049	383	2	(	(	PUNCT
fnp-3049	383	3	2018	2018	NUM
fnp-3049	383	4	)	)	PUNCT
fnp-3049	383	5	.	.	PUNCT
fnp-3049	384	1	doi:10.1007	doi:10.1007	VERB
fnp-3049	384	2	/	/	SYM
fnp-3049	384	3	s12035	s12035	PROPN
fnp-3049	384	4	-	-	PUNCT
fnp-3049	384	5	018	018	NUM
fnp-3049	384	6	-	-	PUNCT
fnp-3049	384	7	1025	1025	NUM
fnp-3049	384	8	-	-	SYM
fnp-3049	384	9	9	9	NUM
fnp-3049	384	10	6	6	NUM
fnp-3049	384	11	.	.	PUNCT
fnp-3049	385	1	athauda	athauda	NOUN
fnp-3049	385	2	,	,	PUNCT
fnp-3049	386	1	d.	d.	PROPN
fnp-3049	386	2	et	et	PROPN
fnp-3049	386	3	al	al	PROPN
fnp-3049	386	4	.	.	PROPN
fnp-3049	386	5	exenatide	exenatide	PROPN
fnp-3049	386	6	once	once	ADV
fnp-3049	386	7	weekly	weekly	ADJ
fnp-3049	386	8	versus	versus	ADP
fnp-3049	386	9	placebo	placebo	NOUN
fnp-3049	386	10	in	in	ADP
fnp-3049	386	11	parkinson	parkinson	NOUN
fnp-3049	386	12	's	's	PART
fnp-3049	386	13	disease	disease	NOUN
fnp-3049	386	14	:	:	PUNCT
fnp-3049	386	15	a	a	DET
fnp-3049	386	16	randomized	randomized	ADJ
fnp-3049	386	17	,	,	PUNCT
fnp-3049	386	18	double	double	ADJ
fnp-3049	386	19	-	-	PUNCT
fnp-3049	386	20	blind	blind	ADJ
fnp-3049	386	21	,	,	PUNCT
fnp-3049	386	22	placebo	placebo	NOUN
fnp-3049	386	23	-	-	PUNCT
fnp-3049	386	24	controlled	control	VERB
fnp-3049	386	25	trial	trial	NOUN
fnp-3049	386	26	.	.	PUNCT
fnp-3049	387	1	the	the	DET
fnp-3049	387	2	lancet	lancet	PROPN
fnp-3049	387	3	390	390	NUM
fnp-3049	387	4	,	,	PUNCT
fnp-3049	387	5	1664–1675	1664–1675	NUM
fnp-3049	387	6	(	(	PUNCT
fnp-3049	387	7	2017	2017	NUM
fnp-3049	387	8	)	)	PUNCT
fnp-3049	387	9	.	.	PUNCT
fnp-3049	388	1	7	7	X
fnp-3049	388	2	.	.	X
fnp-3049	388	3	athauda	athauda	NOUN
fnp-3049	388	4	,	,	PUNCT
fnp-3049	388	5	d.	d.	PROPN
fnp-3049	388	6	et	et	PROPN
fnp-3049	388	7	al	al	PROPN
fnp-3049	388	8	.	.	PUNCT
fnp-3049	389	1	what	what	PRON
fnp-3049	389	2	effects	effect	NOUN
fnp-3049	389	3	might	might	AUX
fnp-3049	389	4	exenatide	exenatide	VERB
fnp-3049	389	5	have	have	VERB
fnp-3049	389	6	on	on	ADP
fnp-3049	389	7	non	non	ADJ
fnp-3049	389	8	-	-	ADJ
fnp-3049	389	9	motor	motor	ADJ
fnp-3049	389	10	symptoms	symptom	NOUN
fnp-3049	389	11	in	in	ADP
fnp-3049	389	12	parkinson	parkinson	NOUN
fnp-3049	389	13	’s	’s	PART
fnp-3049	389	14	disease	disease	NOUN
fnp-3049	389	15	:	:	PUNCT
fnp-3049	389	16	a	a	DET
fnp-3049	389	17	post	post	X
fnp-3049	389	18	hoc	hoc	X
fnp-3049	389	19	analysis	analysis	NOUN
fnp-3049	389	20	.	.	PUNCT
fnp-3049	390	1	jpd	jpd	ADP
fnp-3049	390	2	8	8	NUM
fnp-3049	390	3	,	,	PUNCT
fnp-3049	390	4	247–258	247–258	NUM
fnp-3049	390	5	(	(	PUNCT
fnp-3049	390	6	2018	2018	NUM
fnp-3049	390	7	)	)	PUNCT
fnp-3049	390	8	.	.	PUNCT
fnp-3049	391	1	8	8	X
fnp-3049	391	2	.	.	X
fnp-3049	391	3	ninds	nind	VERB
fnp-3049	391	4	exploratory	exploratory	ADJ
fnp-3049	391	5	trials	trial	NOUN
fnp-3049	391	6	in	in	ADP
fnp-3049	391	7	parkinson	parkinson	NOUN
fnp-3049	391	8	disease	disease	NOUN
fnp-3049	391	9	net	net	ADJ
fnp-3049	391	10	-	-	PUNCT
fnp-3049	391	11	pd	pd	INTJ
fnp-3049	391	12	fs	fs	PROPN
fnp-3049	391	13	-	-	NOUN
fnp-3049	391	14	zone	zone	NOUN
fnp-3049	391	15	.	.	PUNCT
fnp-3049	392	1	pioglitazone	pioglitazone	NOUN
fnp-3049	392	2	in	in	ADP
fnp-3049	392	3	early	early	ADJ
fnp-3049	392	4	parkinson	parkinson	NOUN
fnp-3049	392	5	’s	’s	PART
fnp-3049	392	6	disease	disease	NOUN
fnp-3049	392	7	:	:	PUNCT
fnp-3049	392	8	a	a	DET
fnp-3049	392	9	phase	phase	NOUN
fnp-3049	392	10	2	2	NUM
fnp-3049	392	11	,	,	PUNCT
fnp-3049	392	12	multicenter	multicenter	NOUN
fnp-3049	392	13	,	,	PUNCT
fnp-3049	392	14	double	double	ADJ
fnp-3049	392	15	-	-	PUNCT
fnp-3049	392	16	blind	blind	ADJ
fnp-3049	392	17	,	,	PUNCT
fnp-3049	392	18	randomized	randomize	VERB
fnp-3049	392	19	trial	trial	NOUN
fnp-3049	392	20	.	.	PUNCT
fnp-3049	393	1	the	the	DET
fnp-3049	393	2	lancet	lancet	PROPN
fnp-3049	393	3	neurology	neurology	NOUN
fnp-3049	393	4	14	14	NUM
fnp-3049	393	5	,	,	PUNCT
fnp-3049	393	6	795–803	795–803	NUM
fnp-3049	393	7	(	(	PUNCT
fnp-3049	393	8	2015	2015	NUM
fnp-3049	393	9	)	)	PUNCT
fnp-3049	393	10	.	.	PUNCT
fnp-3049	394	1	9	9	X
fnp-3049	394	2	.	.	X
fnp-3049	394	3	chen	chen	PROPN
fnp-3049	394	4	,	,	PUNCT
fnp-3049	394	5	z.	z.	PROPN
fnp-3049	394	6	et	et	PROPN
fnp-3049	394	7	al	al	PROPN
fnp-3049	394	8	.	.	PROPN
fnp-3049	394	9	insulin	insulin	NOUN
fnp-3049	394	10	resistance	resistance	NOUN
fnp-3049	394	11	and	and	CCONJ
fnp-3049	394	12	metabolic	metabolic	NOUN
fnp-3049	394	13	derangements	derangement	NOUN
fnp-3049	394	14	in	in	ADP
fnp-3049	394	15	obese	obese	ADJ
fnp-3049	394	16	mice	mouse	NOUN
fnp-3049	394	17	are	be	AUX
fnp-3049	394	18	ameliorated	ameliorate	VERB
fnp-3049	394	19	by	by	ADP
fnp-3049	394	20	a	a	DET
fnp-3049	394	21	novel	novel	NOUN
fnp-3049	394	22	peroxisome	peroxisome	NOUN
fnp-3049	394	23	proliferator	proliferator	NOUN
fnp-3049	394	24	-	-	PUNCT
fnp-3049	394	25	activated	activate	VERB
fnp-3049	394	26	receptor	receptor	NOUN
fnp-3049	394	27	γ	γ	NOUN
fnp-3049	394	28	-	-	ADJ
fnp-3049	394	29	sparing	spare	VERB
fnp-3049	394	30	thiazolidinedione	thiazolidinedione	NOUN
fnp-3049	394	31	.	.	PUNCT
fnp-3049	395	1	j.	j.	PROPN
fnp-3049	395	2	biol	biol	PROPN
fnp-3049	395	3	.	.	PUNCT
fnp-3049	396	1	chem	chem	PROPN
fnp-3049	396	2	.	.	PUNCT
fnp-3049	397	1	287	287	NUM
fnp-3049	397	2	,	,	PUNCT
fnp-3049	397	3	23537–23548	23537–23548	NUM
fnp-3049	397	4	(	(	PUNCT
fnp-3049	397	5	2012	2012	NUM
fnp-3049	397	6	)	)	PUNCT
fnp-3049	397	7	.	.	PUNCT
fnp-3049	398	1	10	10	NUM
fnp-3049	398	2	.	.	X
fnp-3049	399	1	ghosh	ghosh	PROPN
fnp-3049	399	2	,	,	PUNCT
fnp-3049	399	3	a.	a.	PROPN
fnp-3049	399	4	et	et	PROPN
fnp-3049	399	5	al	al	PROPN
fnp-3049	399	6	.	.	PROPN
fnp-3049	400	1	mitochondrial	mitochondrial	ADJ
fnp-3049	400	2	pyruvate	pyruvate	NOUN
fnp-3049	400	3	carrier	carrier	NOUN
fnp-3049	400	4	regulates	regulate	VERB
fnp-3049	400	5	autophagy	autophagy	NOUN
fnp-3049	400	6	,	,	PUNCT
fnp-3049	400	7	inflammation	inflammation	NOUN
fnp-3049	400	8	,	,	PUNCT
fnp-3049	400	9	and	and	CCONJ
fnp-3049	400	10	neurodegeneration	neurodegeneration	NOUN
fnp-3049	400	11	in	in	ADP
fnp-3049	400	12	experimental	experimental	ADJ
fnp-3049	400	13	models	model	NOUN
fnp-3049	400	14	of	of	ADP
fnp-3049	400	15	parkinson	parkinson	NOUN
fnp-3049	400	16	’s	’s	PART
fnp-3049	400	17	disease	disease	NOUN
fnp-3049	400	18	.	.	PUNCT
fnp-3049	401	1	science	science	NOUN
fnp-3049	401	2	translational	translational	ADJ
fnp-3049	401	3	medicine	medicine	NOUN
fnp-3049	401	4	1–18	1–18	PROPN
fnp-3049	401	5	(	(	PUNCT
fnp-3049	401	6	2016	2016	NUM
fnp-3049	401	7	)	)	PUNCT
fnp-3049	401	8	.	.	PUNCT
fnp-3049	402	1	11	11	NUM
fnp-3049	402	2	.	.	X
fnp-3049	403	1	sonnier	sonnier	PROPN
fnp-3049	403	2	,	,	PUNCT
fnp-3049	403	3	l.	l.	PROPN
fnp-3049	403	4	et	et	PROPN
fnp-3049	403	5	al	al	PROPN
fnp-3049	403	6	.	.	PROPN
fnp-3049	403	7	progressive	progressive	ADJ
fnp-3049	403	8	loss	loss	NOUN
fnp-3049	403	9	of	of	ADP
fnp-3049	403	10	dopaminergic	dopaminergic	ADJ
fnp-3049	403	11	neurons	neuron	NOUN
fnp-3049	403	12	in	in	ADP
fnp-3049	403	13	the	the	DET
fnp-3049	403	14	ventral	ventral	ADJ
fnp-3049	403	15	midbrain	midbrain	NOUN
fnp-3049	403	16	of	of	ADP
fnp-3049	403	17	adult	adult	NOUN
fnp-3049	403	18	mice	mouse	NOUN
fnp-3049	403	19	heterozygote	heterozygote	NOUN
fnp-3049	403	20	for	for	ADP
fnp-3049	403	21	engrailed1	engrailed1	PROPN
fnp-3049	403	22	.	.	PUNCT
fnp-3049	404	1	j.	j.	PROPN
fnp-3049	404	2	neurosci	neurosci	PROPN
fnp-3049	404	3	.	.	PUNCT
fnp-3049	405	1	27	27	NUM
fnp-3049	405	2	,	,	PUNCT
fnp-3049	405	3	1063–1071	1063–1071	NUM
fnp-3049	405	4	(	(	PUNCT
fnp-3049	405	5	2007	2007	NUM
fnp-3049	405	6	)	)	PUNCT
fnp-3049	405	7	.	.	PUNCT
fnp-3049	406	1	12	12	NUM
fnp-3049	406	2	.	.	PUNCT
fnp-3049	406	3	becker	becker	PROPN
fnp-3049	406	4	,	,	PUNCT
fnp-3049	406	5	k.	k.	PROPN
fnp-3049	406	6	et	et	PROPN
fnp-3049	406	7	al	al	PROPN
fnp-3049	406	8	.	.	PUNCT
fnp-3049	407	1	detecting	detect	VERB
fnp-3049	407	2	alpha	alpha	NOUN
fnp-3049	407	3	synuclein	synuclein	NOUN
fnp-3049	407	4	seeding	seed	VERB
fnp-3049	407	5	activity	activity	NOUN
fnp-3049	407	6	in	in	ADP
fnp-3049	407	7	formaldehyde	formaldehyde	NOUN
fnp-3049	407	8	-	-	PUNCT
fnp-3049	407	9	fixed	fix	VERB
fnp-3049	407	10	msa	msa	PROPN
fnp-3049	407	11	patient	patient	ADJ
fnp-3049	407	12	tissue	tissue	NOUN
fnp-3049	407	13	by	by	ADP
fnp-3049	407	14	pmca	pmca	NOUN
fnp-3049	407	15	.	.	PUNCT
fnp-3049	408	1	mol	mol	ADP
fnp-3049	408	2	neurobiol	neurobiol	PROPN
fnp-3049	408	3	55	55	NUM
fnp-3049	408	4	,	,	PUNCT
fnp-3049	408	5	1–10	1–10	NOUN
fnp-3049	408	6	(	(	PUNCT
fnp-3049	408	7	2018	2018	NUM
fnp-3049	408	8	)	)	PUNCT
fnp-3049	408	9	.	.	PUNCT
fnp-3049	409	1	13	13	NUM
fnp-3049	409	2	.	.	X
fnp-3049	409	3	george	george	PROPN
fnp-3049	409	4	,	,	PUNCT
fnp-3049	409	5	s.	s.	PROPN
fnp-3049	409	6	et	et	PROPN
fnp-3049	409	7	al	al	PROPN
fnp-3049	409	8	.	.	PUNCT
fnp-3049	410	1	microglia	microglia	PROPN
fnp-3049	410	2	affect	affect	VERB
fnp-3049	410	3	α	α	NUM
fnp-3049	410	4	-	-	PUNCT
fnp-3049	410	5	synuclein	synuclein	NOUN
fnp-3049	410	6	cell	cell	NOUN
fnp-3049	410	7	-	-	PUNCT
fnp-3049	410	8	to	to	ADP
fnp-3049	410	9	-	-	PUNCT
fnp-3049	410	10	cell	cell	NOUN
fnp-3049	410	11	transfer	transfer	NOUN
fnp-3049	410	12	in	in	ADP
fnp-3049	410	13	a	a	DET
fnp-3049	410	14	mouse	mouse	NOUN
fnp-3049	410	15	model	model	NOUN
fnp-3049	410	16	of	of	ADP
fnp-3049	410	17	parkinson	parkinson	NOUN
fnp-3049	410	18	’s	’s	PART
fnp-3049	410	19	disease	disease	NOUN
fnp-3049	410	20	.	.	PUNCT
fnp-3049	411	1	mol	mol	ADP
fnp-3049	411	2	neurodegeneration	neurodegeneration	NOUN
fnp-3049	411	3	14	14	NUM
fnp-3049	411	4	,	,	PUNCT
fnp-3049	411	5	1–22	1–22	PROPN
fnp-3049	411	6	(	(	PUNCT
fnp-3049	411	7	2019	2019	NUM
fnp-3049	411	8	)	)	PUNCT
fnp-3049	411	9	.	.	PUNCT
fnp-3049	412	1	14	14	NUM
fnp-3049	412	2	.	.	PUNCT
fnp-3049	413	1	van	van	PROPN
fnp-3049	413	2	der	der	PROPN
fnp-3049	413	3	perren	perren	NOUN
fnp-3049	413	4	,	,	PUNCT
fnp-3049	413	5	a.	a.	PROPN
fnp-3049	413	6	et	et	PROPN
fnp-3049	413	7	al	al	PROPN
fnp-3049	413	8	.	.	PROPN
fnp-3049	413	9	development	development	NOUN
fnp-3049	413	10	of	of	ADP
fnp-3049	413	11	an	an	DET
fnp-3049	413	12	alpha	alpha	NOUN
fnp-3049	413	13	-	-	PUNCT
fnp-3049	413	14	synuclein	synuclein	NOUN
fnp-3049	413	15	based	base	VERB
fnp-3049	413	16	rat	rat	NOUN
fnp-3049	413	17	model	model	NOUN
fnp-3049	413	18	for	for	ADP
fnp-3049	413	19	parkinson	parkinson	NOUN
fnp-3049	413	20	's	's	PART
fnp-3049	413	21	disease	disease	NOUN
fnp-3049	413	22	via	via	ADP
fnp-3049	413	23	stereotactic	stereotactic	ADJ
fnp-3049	413	24	injection	injection	NOUN
fnp-3049	413	25	of	of	ADP
fnp-3049	413	26	a	a	DET
fnp-3049	413	27	recombinant	recombinant	ADJ
fnp-3049	413	28	adeno	adeno	NOUN
fnp-3049	413	29	-	-	PUNCT
fnp-3049	413	30	associated	associate	VERB
fnp-3049	413	31	viral	viral	ADJ
fnp-3049	413	32	vector	vector	NOUN
fnp-3049	413	33	.	.	PUNCT
fnp-3049	414	1	jove	jove	PROPN
fnp-3049	414	2	1–8	1–8	PROPN
fnp-3049	414	3	(	(	PUNCT
fnp-3049	414	4	2016	2016	NUM
fnp-3049	414	5	)	)	PUNCT
fnp-3049	414	6	.	.	PUNCT
fnp-3049	415	1	doi:10.3791/53670	doi:10.3791/53670	VERB
fnp-3049	415	2	15	15	NUM
fnp-3049	415	3	.	.	PUNCT
fnp-3049	416	1	colca	colca	NOUN
fnp-3049	416	2	,	,	PUNCT
fnp-3049	416	3	j.	j.	PROPN
fnp-3049	416	4	r.	r.	PROPN
fnp-3049	416	5	et	et	PROPN
fnp-3049	416	6	al	al	PROPN
fnp-3049	416	7	.	.	PUNCT
fnp-3049	417	1	clinical	clinical	ADJ
fnp-3049	417	2	proof	proof	NOUN
fnp-3049	417	3	-	-	PUNCT
fnp-3049	417	4	of	of	ADP
fnp-3049	417	5	-	-	PUNCT
fnp-3049	417	6	concept	concept	NOUN
fnp-3049	417	7	study	study	NOUN
fnp-3049	417	8	with	with	ADP
fnp-3049	417	9	msdc-0160	msdc-0160	ADJ
fnp-3049	417	10	,	,	PUNCT
fnp-3049	417	11	a	a	DET
fnp-3049	417	12	prototype	prototype	NOUN
fnp-3049	417	13	mtot	mtot	NOUN
fnp-3049	417	14	-	-	PUNCT
fnp-3049	417	15	modulating	modulate	VERB
fnp-3049	417	16	insulin	insulin	NOUN
fnp-3049	417	17	sensitizer	sensitizer	NOUN
fnp-3049	417	18	.	.	PUNCT
fnp-3049	418	1	clin	clin	PROPN
fnp-3049	418	2	pharmacol	pharmacol	PROPN
fnp-3049	418	3	ther	ther	PROPN
fnp-3049	418	4	93	93	NUM
fnp-3049	418	5	,	,	PUNCT
fnp-3049	418	6	352–359	352–359	NUM
fnp-3049	418	7	(	(	PUNCT
fnp-3049	418	8	2013	2013	NUM
fnp-3049	418	9	)	)	PUNCT
fnp-3049	418	10	.	.	PUNCT
fnp-3049	419	1	16	16	NUM
fnp-3049	419	2	.	.	PUNCT
fnp-3049	420	1	johnson	johnson	PROPN
fnp-3049	420	2	,	,	PUNCT
fnp-3049	420	3	m.	m.	PROPN
fnp-3049	420	4	e.	e.	PROPN
fnp-3049	420	5	et	et	PROPN
fnp-3049	420	6	al	al	PROPN
fnp-3049	420	7	.	.	PROPN
fnp-3049	420	8	deficits	deficit	NOUN
fnp-3049	420	9	in	in	ADP
fnp-3049	420	10	olfactory	olfactory	ADJ
fnp-3049	420	11	sensitivity	sensitivity	NOUN
fnp-3049	420	12	in	in	ADP
fnp-3049	420	13	a	a	DET
fnp-3049	420	14	mouse	mouse	NOUN
fnp-3049	420	15	model	model	NOUN
fnp-3049	420	16	of	of	ADP
fnp-3049	420	17	parkinson	parkinson	NOUN
fnp-3049	420	18	’s	’s	PART
fnp-3049	420	19	disease	disease	NOUN
fnp-3049	420	20	revealed	reveal	VERB
fnp-3049	420	21	by	by	ADP
fnp-3049	420	22	plethysmography	plethysmography	NOUN
fnp-3049	420	23	of	of	ADP
fnp-3049	420	24	odor	odor	NOUN
fnp-3049	420	25	-	-	PUNCT
fnp-3049	420	26	evoked	evoke	VERB
fnp-3049	420	27	sniffing	sniffing	NOUN
fnp-3049	420	28	.	.	PUNCT
fnp-3049	421	1	scientific	scientific	ADJ
fnp-3049	421	2	reports	report	NOUN
fnp-3049	421	3	1–13	1–13	NOUN
fnp-3049	421	4	(	(	PUNCT
fnp-3049	421	5	2020	2020	NUM
fnp-3049	421	6	)	)	PUNCT
fnp-3049	421	7	.	.	PUNCT
fnp-3049	422	1	doi:10.1038	doi:10.1038	NOUN
fnp-3049	422	2	/	/	SYM
fnp-3049	422	3	s41598	s41598	NOUN
fnp-3049	422	4	-	-	PUNCT
fnp-3049	422	5	020	020	NUM
fnp-3049	422	6	-	-	PUNCT
fnp-3049	422	7	66201	66201	NUM
fnp-3049	422	8	-	-	SYM
fnp-3049	422	9	8	8	NUM
fnp-3049	422	10	17	17	NUM
fnp-3049	422	11	.	.	PUNCT
fnp-3049	422	12	di	di	PROPN
fnp-3049	422	13	maio	maio	PROPN
fnp-3049	422	14	,	,	PUNCT
fnp-3049	422	15	r.	r.	PROPN
fnp-3049	422	16	et	et	PROPN
fnp-3049	422	17	al	al	PROPN
fnp-3049	422	18	.	.	PUNCT
fnp-3049	423	1	α	α	X
fnp-3049	423	2	-	-	PUNCT
fnp-3049	423	3	synuclein	synuclein	NOUN
fnp-3049	423	4	binds	bind	VERB
fnp-3049	423	5	to	to	ADP
fnp-3049	423	6	tom20	tom20	NOUN
fnp-3049	423	7	and	and	CCONJ
fnp-3049	423	8	inhibits	inhibit	VERB
fnp-3049	423	9	mitochondrial	mitochondrial	ADJ
fnp-3049	423	10	protein	protein	NOUN
fnp-3049	423	11	import	import	NOUN
fnp-3049	423	12	in	in	ADP
fnp-3049	423	13	parkinson	parkinson	NOUN
fnp-3049	423	14	's	's	PART
fnp-3049	423	15	disease	disease	NOUN
fnp-3049	423	16	.	.	PUNCT
fnp-3049	424	1	science	science	NOUN
fnp-3049	424	2	translational	translational	ADJ
fnp-3049	424	3	medicine	medicine	NOUN
fnp-3049	424	4	8	8	NUM
fnp-3049	424	5	,	,	PUNCT
fnp-3049	424	6	342ra78–342ra78	342ra78–342ra78	NUM
fnp-3049	424	7	(	(	PUNCT
fnp-3049	424	8	2016	2016	NUM
fnp-3049	424	9	)	)	PUNCT
fnp-3049	424	10	.	.	PUNCT
fnp-3049	425	1	18	18	NUM
fnp-3049	425	2	.	.	PUNCT
fnp-3049	425	3	ryan	ryan	PROPN
fnp-3049	425	4	,	,	PUNCT
fnp-3049	425	5	t.	t.	PROPN
fnp-3049	425	6	et	et	PROPN
fnp-3049	425	7	al	al	PROPN
fnp-3049	425	8	.	.	PUNCT
fnp-3049	425	9	cardiolipin	cardiolipin	PROPN
fnp-3049	425	10	exposure	exposure	NOUN
fnp-3049	425	11	on	on	ADP
fnp-3049	425	12	the	the	DET
fnp-3049	425	13	outer	outer	ADJ
fnp-3049	425	14	mitochondrial	mitochondrial	ADJ
fnp-3049	425	15	membrane	membrane	NOUN
fnp-3049	425	16	modulates	modulate	NOUN
fnp-3049	425	17	α	α	NOUN
fnp-3049	425	18	-	-	PUNCT
fnp-3049	425	19	synuclein	synuclein	NOUN
fnp-3049	425	20	.	.	PUNCT
fnp-3049	426	1	nature	nature	NOUN
fnp-3049	426	2	communications	communications	PROPN
fnp-3049	426	3	1–17	1–17	PROPN
fnp-3049	426	4	(	(	PUNCT
fnp-3049	426	5	2018	2018	NUM
fnp-3049	426	6	)	)	PUNCT
fnp-3049	426	7	.	.	PUNCT
fnp-3049	427	1	doi:10.1038	doi:10.1038	NOUN
fnp-3049	427	2	/	/	SYM
fnp-3049	427	3	s41467	s41467	NOUN
fnp-3049	427	4	-	-	PUNCT
fnp-3049	427	5	018	018	NUM
fnp-3049	427	6	-	-	PUNCT
fnp-3049	427	7	03241	03241	NUM
fnp-3049	427	8	-	-	SYM
fnp-3049	427	9	9	9	NUM
fnp-3049	427	10	19	19	NUM
fnp-3049	427	11	.	.	PUNCT
fnp-3049	427	12	winklhofer	winklhofer	PROPN
fnp-3049	427	13	,	,	PUNCT
fnp-3049	427	14	k.	k.	PROPN
fnp-3049	427	15	f.	f.	PROPN
fnp-3049	427	16	&	&	CCONJ
fnp-3049	427	17	haass	haass	PROPN
fnp-3049	427	18	,	,	PUNCT
fnp-3049	427	19	c.	c.	PROPN
fnp-3049	427	20	mitochondrial	mitochondrial	ADJ
fnp-3049	427	21	dysfunction	dysfunction	NOUN
fnp-3049	427	22	in	in	ADP
fnp-3049	427	23	parkinson	parkinson	NOUN
fnp-3049	427	24	's	's	PART
fnp-3049	427	25	disease	disease	NOUN
fnp-3049	427	26	.	.	PUNCT
fnp-3049	428	1	bba	bba	PROPN
fnp-3049	428	2	molecular	molecular	ADJ
fnp-3049	428	3	basis	basis	NOUN
fnp-3049	428	4	of	of	ADP
fnp-3049	428	5	disease	disease	NOUN
fnp-3049	428	6	1802	1802	NUM
fnp-3049	428	7	,	,	PUNCT
fnp-3049	428	8	29–44	29–44	NUM
fnp-3049	428	9	(	(	PUNCT
fnp-3049	428	10	2010	2010	NUM
fnp-3049	428	11	)	)	PUNCT
fnp-3049	428	12	.	.	PUNCT
fnp-3049	429	1	20	20	NUM
fnp-3049	429	2	.	.	PUNCT
fnp-3049	429	3	rey	rey	PROPN
fnp-3049	429	4	,	,	PUNCT
fnp-3049	429	5	n.	n.	PROPN
fnp-3049	429	6	l.	l.	PROPN
fnp-3049	429	7	et	et	PROPN
fnp-3049	429	8	al	al	PROPN
fnp-3049	429	9	.	.	PROPN
fnp-3049	430	1	widespread	widespread	ADJ
fnp-3049	430	2	transneuronal	transneuronal	ADJ
fnp-3049	430	3	propagation	propagation	NOUN
fnp-3049	430	4	of	of	ADP
fnp-3049	430	5	α	α	NOUN
fnp-3049	430	6	-	-	PUNCT
fnp-3049	430	7	synucleinopathy	synucleinopathy	NOUN
fnp-3049	430	8	triggered	trigger	VERB
fnp-3049	430	9	in	in	ADP
fnp-3049	430	10	olfactory	olfactory	ADJ
fnp-3049	430	11	bulb	bulb	NOUN
fnp-3049	430	12	mimics	mimic	VERB
fnp-3049	430	13	prodromal	prodromal	ADJ
fnp-3049	430	14	parkinson	parkinson	NOUN
fnp-3049	430	15	’s	’s	PART
fnp-3049	430	16	disease	disease	NOUN
fnp-3049	430	17	.	.	PUNCT
fnp-3049	431	1	the	the	DET
fnp-3049	431	2	journal	journal	NOUN
fnp-3049	431	3	of	of	ADP
fnp-3049	431	4	experimental	experimental	ADJ
fnp-3049	431	5	medicine	medicine	NOUN
fnp-3049	431	6	213	213	NUM
fnp-3049	431	7	,	,	PUNCT
fnp-3049	431	8	1759–1778	1759–1778	NUM
fnp-3049	431	9	(	(	PUNCT
fnp-3049	431	10	2016	2016	NUM
fnp-3049	431	11	)	)	PUNCT
fnp-3049	431	12	.	.	PUNCT
fnp-3049	432	1	21	21	NUM
fnp-3049	432	2	.	.	PUNCT
fnp-3049	432	3	klingstedt	klingstedt	PROPN
fnp-3049	432	4	,	,	PUNCT
fnp-3049	432	5	t.	t.	PROPN
fnp-3049	432	6	et	et	PROPN
fnp-3049	432	7	al	al	PROPN
fnp-3049	432	8	.	.	PUNCT
fnp-3049	432	9	synthesis	synthesis	NOUN
fnp-3049	432	10	of	of	ADP
fnp-3049	432	11	a	a	DET
fnp-3049	432	12	library	library	NOUN
fnp-3049	432	13	of	of	ADP
fnp-3049	432	14	oligothiophenes	oligothiophene	NOUN
fnp-3049	432	15	and	and	CCONJ
fnp-3049	432	16	their	their	PRON
fnp-3049	432	17	utilization	utilization	NOUN
fnp-3049	432	18	as	as	ADP
fnp-3049	432	19	fluorescent	fluorescent	ADJ
fnp-3049	432	20	ligands	ligand	NOUN
fnp-3049	432	21	for	for	ADP
fnp-3049	432	22	spectral	spectral	ADJ
fnp-3049	432	23	assignment	assignment	NOUN
fnp-3049	432	24	of	of	ADP
fnp-3049	432	25	protein	protein	NOUN
fnp-3049	432	26	aggregates	aggregate	NOUN
fnp-3049	432	27	.	.	PUNCT
fnp-3049	433	1	org	org	NOUN
fnp-3049	433	2	.	.	PUNCT
fnp-3049	433	3	biomol	biomol	PROPN
fnp-3049	433	4	.	.	PUNCT
fnp-3049	434	1	chem	chem	NOUN
fnp-3049	434	2	.	.	PUNCT
fnp-3049	435	1	9	9	NUM
fnp-3049	435	2	,	,	PUNCT
fnp-3049	435	3	8356–25	8356–25	NUM
fnp-3049	435	4	(	(	PUNCT
fnp-3049	435	5	2011	2011	NUM
fnp-3049	435	6	)	)	PUNCT
fnp-3049	435	7	.	.	PUNCT
fnp-3049	436	1	22	22	NUM
fnp-3049	436	2	.	.	PUNCT
fnp-3049	437	1	cheong	cheong	PROPN
fnp-3049	437	2	,	,	PUNCT
fnp-3049	437	3	j.	j.	PROPN
fnp-3049	437	4	l.	l.	PROPN
fnp-3049	437	5	y.	y.	PROPN
fnp-3049	437	6	,	,	PUNCT
fnp-3049	437	7	de	de	ADP
fnp-3049	437	8	pablo	pablo	NOUN
fnp-3049	437	9	-	-	PUNCT
fnp-3049	437	10	fernandez	fernandez	PROPN
fnp-3049	437	11	,	,	PUNCT
fnp-3049	437	12	e.	e.	PROPN
fnp-3049	437	13	,	,	PUNCT
fnp-3049	437	14	foltynie	foltynie	PROPN
fnp-3049	437	15	,	,	PUNCT
fnp-3049	437	16	t.	t.	PROPN
fnp-3049	437	17	&	&	CCONJ
fnp-3049	437	18	noyce	noyce	PROPN
fnp-3049	437	19	,	,	PUNCT
fnp-3049	437	20	a.	a.	PROPN
fnp-3049	437	21	j.	j.	PROPN
fnp-3049	437	22	the	the	DET
fnp-3049	437	23	association	association	NOUN
fnp-3049	437	24	between	between	ADP
fnp-3049	437	25	type	type	NOUN
fnp-3049	437	26	2	2	NUM
fnp-3049	437	27	diabetes	diabetes	NOUN
fnp-3049	437	28	mellitus	mellitus	NOUN
fnp-3049	437	29	and	and	CCONJ
fnp-3049	437	30	parkinson	parkinson	NOUN
fnp-3049	437	31	’s	’s	PART
fnp-3049	437	32	disease	disease	NOUN
fnp-3049	437	33	.	.	PUNCT
fnp-3049	438	1	jpd	jpd	ADP
fnp-3049	438	2	10	10	NUM
fnp-3049	438	3	,	,	PUNCT
fnp-3049	438	4	775–789	775–789	NUM
fnp-3049	438	5	(	(	PUNCT
fnp-3049	438	6	2020	2020	NUM
fnp-3049	438	7	)	)	PUNCT
fnp-3049	438	8	.	.	PUNCT
fnp-3049	439	1	23	23	NUM
fnp-3049	439	2	.	.	PUNCT
fnp-3049	440	1	peelaerts	peelaert	NOUN
fnp-3049	440	2	,	,	PUNCT
fnp-3049	440	3	w.	w.	PROPN
fnp-3049	440	4	&	&	CCONJ
fnp-3049	440	5	baekelandt	baekelandt	PROPN
fnp-3049	440	6	,	,	PUNCT
fnp-3049	440	7	v.	v.	ADP
fnp-3049	440	8	α	α	X
fnp-3049	440	9	-	-	PUNCT
fnp-3049	440	10	synuclein	synuclein	NOUN
fnp-3049	440	11	strains	strain	NOUN
fnp-3049	440	12	and	and	CCONJ
fnp-3049	440	13	the	the	DET
fnp-3049	440	14	variable	variable	ADJ
fnp-3049	440	15	pathologies	pathology	NOUN
fnp-3049	440	16	of	of	ADP
fnp-3049	440	17	synucleinopathies	synucleinopathie	NOUN
fnp-3049	440	18	.	.	PUNCT
fnp-3049	441	1	j.	j.	PROPN
fnp-3049	441	2	neurochem	neurochem	PROPN
fnp-3049	441	3	.	.	PUNCT
fnp-3049	442	1	256–274	256–274	NUM
fnp-3049	442	2	(	(	PUNCT
fnp-3049	442	3	2016	2016	NUM
fnp-3049	442	4	)	)	PUNCT
fnp-3049	442	5	.	.	PUNCT
fnp-3049	443	1	doi:10.1111/(issn)1471	doi:10.1111/(issn)1471	NOUN
fnp-3049	443	2	-	-	PUNCT
fnp-3049	443	3	4159	4159	NUM
fnp-3049	443	4	/	/	SYM
fnp-3049	443	5	homepage	homepage	NOUN
fnp-3049	443	6	/	/	SYM
fnp-3049	443	7	special_issues.htm	special_issues.htm	NOUN
fnp-3049	443	8	24	24	NUM
fnp-3049	443	9	.	.	PUNCT
fnp-3049	443	10	galvagnion	galvagnion	NOUN
fnp-3049	443	11	,	,	PUNCT
fnp-3049	443	12	c.	c.	PROPN
fnp-3049	443	13	et	et	PROPN
fnp-3049	443	14	al	al	PROPN
fnp-3049	443	15	.	.	PROPN
fnp-3049	443	16	lipid	lipid	PROPN
fnp-3049	443	17	vesicles	vesicle	NOUN
fnp-3049	443	18	trigger	trigger	VERB
fnp-3049	443	19	α	α	NOUN
fnp-3049	443	20	-	-	PUNCT
fnp-3049	443	21	synuclein	synuclein	NOUN
fnp-3049	443	22	aggregation	aggregation	NOUN
fnp-3049	443	23	by	by	ADP
fnp-3049	443	24	stimulating	stimulate	VERB
fnp-3049	443	25	primary	primary	ADJ
fnp-3049	443	26	nucleation	nucleation	NOUN
fnp-3049	443	27	.	.	PUNCT
fnp-3049	444	1	nat	nat	PROPN
fnp-3049	444	2	chem	chem	NOUN
fnp-3049	444	3	biol	biol	PROPN
fnp-3049	444	4	11	11	NUM
fnp-3049	444	5	,	,	PUNCT
fnp-3049	444	6	229–234	229–234	NUM
fnp-3049	444	7	(	(	PUNCT
fnp-3049	444	8	2015	2015	NUM
fnp-3049	444	9	)	)	PUNCT
fnp-3049	444	10	.	.	PUNCT
fnp-3049	445	1	25	25	NUM
fnp-3049	445	2	.	.	PUNCT
fnp-3049	446	1	parihar	parihar	PROPN
fnp-3049	446	2	,	,	PUNCT
fnp-3049	446	3	m.	m.	PROPN
fnp-3049	446	4	s.	s.	PROPN
fnp-3049	446	5	,	,	PUNCT
fnp-3049	446	6	parihar	parihar	PROPN
fnp-3049	446	7	,	,	PUNCT
fnp-3049	446	8	a.	a.	PROPN
fnp-3049	446	9	,	,	PUNCT
fnp-3049	446	10	fujita	fujita	PROPN
fnp-3049	446	11	,	,	PUNCT
fnp-3049	446	12	m.	m.	NOUN
fnp-3049	446	13	,	,	PUNCT
fnp-3049	446	14	hashimoto	hashimoto	NOUN
fnp-3049	446	15	,	,	PUNCT
fnp-3049	446	16	m.	m.	NOUN
fnp-3049	446	17	&	&	CCONJ
fnp-3049	446	18	ghafourifar	ghafourifar	PROPN
fnp-3049	446	19	,	,	PUNCT
fnp-3049	446	20	p.	p.	PROPN
fnp-3049	446	21	mitochondrial	mitochondrial	ADJ
fnp-3049	446	22	association	association	NOUN
fnp-3049	446	23	of	of	ADP
fnp-3049	446	24	alpha	alpha	PROPN
fnp-3049	446	25	-	-	PUNCT
fnp-3049	446	26	synuclein	synuclein	NOUN
fnp-3049	446	27	causes	cause	VERB
fnp-3049	446	28	oxidative	oxidative	ADJ
fnp-3049	446	29	stress	stress	NOUN
fnp-3049	446	30	.	.	PUNCT
fnp-3049	447	1	cell	cell	NOUN
fnp-3049	447	2	.	.	PUNCT
fnp-3049	448	1	mol	mol	PROPN
fnp-3049	448	2	.	.	PROPN
fnp-3049	448	3	life	life	PROPN
fnp-3049	448	4	sci	sci	PROPN
fnp-3049	448	5	.	.	PROPN
fnp-3049	448	6	65	65	NUM
fnp-3049	448	7	,	,	PUNCT
fnp-3049	448	8	1272–1284	1272–1284	NUM
fnp-3049	448	9	(	(	PUNCT
fnp-3049	448	10	2008	2008	NUM
fnp-3049	448	11	)	)	PUNCT
fnp-3049	448	12	.	.	PUNCT
fnp-3049	449	1	26	26	NUM
fnp-3049	449	2	.	.	X
fnp-3049	449	3	rocha	rocha	PROPN
fnp-3049	449	4	,	,	PUNCT
fnp-3049	449	5	e.	e.	PROPN
fnp-3049	449	6	m.	m.	PROPN
fnp-3049	449	7	,	,	PUNCT
fnp-3049	449	8	de	de	PROPN
fnp-3049	449	9	miranda	miranda	PROPN
fnp-3049	449	10	,	,	PUNCT
fnp-3049	449	11	b.	b.	PROPN
fnp-3049	449	12	&	&	CCONJ
fnp-3049	449	13	sanders	sanders	PROPN
fnp-3049	449	14	,	,	PUNCT
fnp-3049	449	15	l.	l.	PROPN
fnp-3049	449	16	h.	h.	PROPN
fnp-3049	449	17	alpha	alpha	PROPN
fnp-3049	449	18	-	-	PUNCT
fnp-3049	449	19	synuclein	synuclein	NOUN
fnp-3049	449	20	:	:	PUNCT
fnp-3049	449	21	pathology	pathology	NOUN
fnp-3049	449	22	,	,	PUNCT
fnp-3049	449	23	mitochondrial	mitochondrial	ADJ
fnp-3049	449	24	dysfunction	dysfunction	NOUN
fnp-3049	449	25	and	and	CCONJ
fnp-3049	449	26	neuroinflammation	neuroinflammation	NOUN
fnp-3049	449	27	in	in	ADP
fnp-3049	449	28	parkinson	parkinson	NOUN
fnp-3049	449	29	’s	’s	PART
fnp-3049	449	30	disease	disease	NOUN
fnp-3049	449	31	.	.	PUNCT
fnp-3049	450	1	neurobiology	neurobiology	NOUN
fnp-3049	450	2	of	of	ADP
fnp-3049	450	3	disease	disease	NOUN
fnp-3049	450	4	109	109	NUM
fnp-3049	450	5	,	,	PUNCT
fnp-3049	450	6	249–257	249–257	NUM
fnp-3049	450	7	(	(	PUNCT
fnp-3049	450	8	2018	2018	NUM
fnp-3049	450	9	)	)	PUNCT
fnp-3049	450	10	.	.	PUNCT
fnp-3049	451	1	27	27	NUM
fnp-3049	451	2	.	.	X
fnp-3049	451	3	yu	yu	PROPN
fnp-3049	451	4	,	,	PUNCT
fnp-3049	451	5	z.	z.	PROPN
fnp-3049	451	6	et	et	PROPN
fnp-3049	451	7	al	al	PROPN
fnp-3049	451	8	.	.	PROPN
fnp-3049	452	1	nitrated	nitrated	PROPN
fnp-3049	452	2	α	α	X
fnp-3049	452	3	-	-	PUNCT
fnp-3049	452	4	synuclein	synuclein	NOUN
fnp-3049	452	5	induces	induce	VERB
fnp-3049	452	6	the	the	DET
fnp-3049	452	7	loss	loss	NOUN
fnp-3049	452	8	of	of	ADP
fnp-3049	452	9	dopaminergic	dopaminergic	ADJ
fnp-3049	452	10	neurons	neuron	NOUN
fnp-3049	452	11	in	in	ADP
fnp-3049	452	12	the	the	DET
fnp-3049	452	13	substantia	substantia	NOUN
fnp-3049	452	14	nigra	nigra	NOUN
fnp-3049	452	15	of	of	ADP
fnp-3049	452	16	rats	rat	NOUN
fnp-3049	452	17	.	.	PUNCT
fnp-3049	453	1	plos	plos	PROPN
fnp-3049	453	2	one	one	NUM
fnp-3049	453	3	5	5	NUM
fnp-3049	453	4	,	,	PUNCT
fnp-3049	453	5	e9956–17	e9956–17	NUM
fnp-3049	453	6	(	(	PUNCT
fnp-3049	453	7	2010	2010	NUM
fnp-3049	453	8	)	)	PUNCT
fnp-3049	453	9	.	.	PUNCT
fnp-3049	454	1	28	28	NUM
fnp-3049	454	2	.	.	PUNCT
fnp-3049	455	1	uversky	uversky	PROPN
fnp-3049	455	2	,	,	PUNCT
fnp-3049	455	3	v.	v.	CCONJ
fnp-3049	455	4	n.	n.	PROPN
fnp-3049	455	5	et	et	PROPN
fnp-3049	455	6	al	al	PROPN
fnp-3049	455	7	.	.	PUNCT
fnp-3049	455	8	effects	effect	NOUN
fnp-3049	455	9	of	of	ADP
fnp-3049	455	10	nitration	nitration	NOUN
fnp-3049	455	11	on	on	ADP
fnp-3049	455	12	the	the	DET
fnp-3049	455	13	structure	structure	NOUN
fnp-3049	455	14	and	and	CCONJ
fnp-3049	455	15	aggregation	aggregation	NOUN
fnp-3049	455	16	of	of	ADP
fnp-3049	455	17	α	α	NOUN
fnp-3049	455	18	-	-	PUNCT
fnp-3049	455	19	synuclein	synuclein	NOUN
fnp-3049	455	20	.	.	PUNCT
fnp-3049	456	1	molecular	molecular	ADJ
fnp-3049	456	2	brain	brain	NOUN
fnp-3049	456	3	research	research	NOUN
fnp-3049	456	4	134	134	NUM
fnp-3049	456	5	,	,	PUNCT
fnp-3049	456	6	84–102	84–102	NUM
fnp-3049	456	7	(	(	PUNCT
fnp-3049	456	8	2005	2005	NUM
fnp-3049	456	9	)	)	PUNCT
fnp-3049	456	10	.	.	PUNCT
fnp-3049	457	1	29	29	NUM
fnp-3049	457	2	.	.	PUNCT
fnp-3049	457	3	shirani	shirani	PROPN
fnp-3049	457	4	,	,	PUNCT
fnp-3049	457	5	h.	h.	PROPN
fnp-3049	457	6	et	et	PROPN
fnp-3049	457	7	al	al	PROPN
fnp-3049	457	8	.	.	PUNCT
fnp-3049	458	1	a	a	DET
fnp-3049	458	2	palette	palette	NOUN
fnp-3049	458	3	of	of	ADP
fnp-3049	458	4	fluorescent	fluorescent	ADJ
fnp-3049	458	5	thiophene	thiophene	NOUN
fnp-3049	458	6	-	-	PUNCT
fnp-3049	458	7	based	base	VERB
fnp-3049	458	8	ligands	ligand	NOUN
fnp-3049	458	9	for	for	ADP
fnp-3049	458	10	the	the	DET
fnp-3049	458	11	identification	identification	NOUN
fnp-3049	458	12	of	of	ADP
fnp-3049	458	13	protein	protein	NOUN
fnp-3049	458	14	aggregates	aggregate	NOUN
fnp-3049	458	15	.	.	PUNCT
fnp-3049	459	1	chem	chem	NOUN
fnp-3049	459	2	.	.	PUNCT
fnp-3049	460	1	eur	eur	PROPN
fnp-3049	460	2	.	.	PUNCT
fnp-3049	461	1	j.	j.	PROPN
fnp-3049	461	2	21	21	PROPN
fnp-3049	461	3	,	,	PUNCT
fnp-3049	461	4	15133–15137	15133–15137	NUM
fnp-3049	461	5	(	(	PUNCT
fnp-3049	461	6	2015	2015	NUM
fnp-3049	461	7	)	)	PUNCT
fnp-3049	461	8	.	.	PUNCT
fnp-3049	462	1	30	30	NUM
fnp-3049	462	2	.	.	PUNCT
fnp-3049	463	1	shahnawaz	shahnawaz	PROPN
fnp-3049	463	2	,	,	PUNCT
fnp-3049	463	3	m.	m.	NOUN
fnp-3049	463	4	et	et	PROPN
fnp-3049	463	5	al	al	PROPN
fnp-3049	463	6	.	.	PUNCT
fnp-3049	464	1	discriminating	discriminate	VERB
fnp-3049	464	2	α	α	PROPN
fnp-3049	464	3	-	-	PUNCT
fnp-3049	464	4	synuclein	synuclein	NOUN
fnp-3049	464	5	strains	strain	NOUN
fnp-3049	464	6	in	in	ADP
fnp-3049	464	7	parkinson	parkinson	NOUN
fnp-3049	464	8	’s	’s	PART
fnp-3049	464	9	disease	disease	NOUN
fnp-3049	464	10	and	and	CCONJ
fnp-3049	464	11	multiple	multiple	ADJ
fnp-3049	464	12	system	system	NOUN
fnp-3049	464	13	atrophy	atrophy	NOUN
fnp-3049	464	14	.	.	PUNCT
fnp-3049	465	1	nature	nature	PROPN
fnp-3049	465	2	1–23	1–23	PROPN
fnp-3049	465	3	(	(	PUNCT
fnp-3049	465	4	2020	2020	NUM
fnp-3049	465	5	)	)	PUNCT
fnp-3049	465	6	.	.	PUNCT
fnp-3049	466	1	doi:10.1038	doi:10.1038	NOUN
fnp-3049	466	2	/	/	SYM
fnp-3049	466	3	s41586	s41586	PROPN
fnp-3049	466	4	-	-	PUNCT
fnp-3049	466	5	020	020	NUM
fnp-3049	466	6	-	-	PUNCT
fnp-3049	466	7	1984	1984	NUM
fnp-3049	466	8	-	-	SYM
fnp-3049	466	9	7	7	NUM
fnp-3049	466	10	31	31	NUM
fnp-3049	466	11	.	.	PUNCT
fnp-3049	467	1	gómez	gómez	NOUN
fnp-3049	467	2	-	-	PUNCT
fnp-3049	467	3	benito	benito	PROPN
fnp-3049	467	4	,	,	PUNCT
fnp-3049	467	5	m.	m.	NOUN
fnp-3049	467	6	et	et	PROPN
fnp-3049	467	7	al	al	PROPN
fnp-3049	467	8	.	.	PROPN
fnp-3049	468	1	modeling	model	VERB
fnp-3049	468	2	parkinson	parkinson	NOUN
fnp-3049	468	3	’s	’s	PART
fnp-3049	468	4	disease	disease	NOUN
fnp-3049	468	5	with	with	ADP
fnp-3049	468	6	the	the	DET
fnp-3049	468	7	alpha	alpha	NOUN
fnp-3049	468	8	-	-	PUNCT
fnp-3049	468	9	synuclein	synuclein	NOUN
fnp-3049	468	10	protein	protein	NOUN
fnp-3049	468	11	.	.	PUNCT
fnp-3049	469	1	front	front	NOUN
fnp-3049	469	2	.	.	PUNCT
fnp-3049	470	1	pharmacol	pharmacol	NOUN
fnp-3049	470	2	.	.	PUNCT
fnp-3049	471	1	11	11	NUM
fnp-3049	471	2	,	,	PUNCT
fnp-3049	471	3	1–15	1–15	NUM
fnp-3049	471	4	(	(	PUNCT
fnp-3049	471	5	2020	2020	NUM
fnp-3049	471	6	)	)	PUNCT
fnp-3049	471	7	.	.	PUNCT
fnp-3049	472	1	copyright	copyright	NOUN
fnp-3049	472	2	:	:	PUNCT
fnp-3049	472	3	©	©	PROPN
fnp-3049	472	4	2020	2020	NUM
fnp-3049	472	5	the	the	DET
fnp-3049	472	6	author(s	author(s	NOUN
fnp-3049	472	7	)	)	PUNCT
fnp-3049	472	8	.	.	PUNCT
fnp-3049	473	1	this	this	PRON
fnp-3049	473	2	is	be	AUX
fnp-3049	473	3	an	an	DET
fnp-3049	473	4	open	open	ADJ
fnp-3049	473	5	access	access	NOUN
fnp-3049	473	6	article	article	NOUN
fnp-3049	473	7	distributed	distribute	VERB
fnp-3049	473	8	under	under	ADP
fnp-3049	473	9	the	the	DET
fnp-3049	473	10	terms	term	NOUN
fnp-3049	473	11	of	of	ADP
fnp-3049	473	12	the	the	DET
fnp-3049	473	13	creative	creative	ADJ
fnp-3049	473	14	commons	common	NOUN
fnp-3049	473	15	attribution	attribution	NOUN
fnp-3049	473	16	4.0	4.0	NUM
fnp-3049	473	17	international	international	ADJ
fnp-3049	473	18	license	license	NOUN
fnp-3049	473	19	(	(	PUNCT
fnp-3049	473	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-3049	473	21	)	)	PUNCT
fnp-3049	473	22	,	,	PUNCT
fnp-3049	473	23	which	which	PRON
fnp-3049	473	24	permits	permit	VERB
fnp-3049	473	25	unrestricted	unrestricted	ADJ
fnp-3049	473	26	use	use	NOUN
fnp-3049	473	27	,	,	PUNCT
fnp-3049	473	28	distribution	distribution	NOUN
fnp-3049	473	29	,	,	PUNCT
fnp-3049	473	30	and	and	CCONJ
fnp-3049	473	31	reproduction	reproduction	NOUN
fnp-3049	473	32	in	in	ADP
fnp-3049	473	33	any	any	DET
fnp-3049	473	34	medium	medium	NOUN
fnp-3049	473	35	,	,	PUNCT
fnp-3049	473	36	provided	provide	VERB
fnp-3049	473	37	the	the	DET
fnp-3049	473	38	original	original	ADJ
fnp-3049	473	39	author	author	NOUN
fnp-3049	473	40	and	and	CCONJ
fnp-3049	473	41	source	source	NOUN
fnp-3049	473	42	are	be	AUX
fnp-3049	473	43	credited	credit	VERB
fnp-3049	473	44	,	,	PUNCT
fnp-3049	473	45	a	a	DET
fnp-3049	473	46	link	link	NOUN
fnp-3049	473	47	to	to	ADP
fnp-3049	473	48	the	the	DET
fnp-3049	473	49	creative	creative	ADJ
fnp-3049	473	50	commons	common	NOUN
fnp-3049	473	51	license	license	NOUN
fnp-3049	473	52	is	be	AUX
fnp-3049	473	53	provided	provide	VERB
fnp-3049	473	54	,	,	PUNCT
fnp-3049	473	55	and	and	CCONJ
fnp-3049	473	56	any	any	DET
fnp-3049	473	57	changes	change	NOUN
fnp-3049	473	58	are	be	AUX
fnp-3049	473	59	indicated	indicate	VERB
fnp-3049	473	60	.	.	PUNCT
fnp-3049	474	1	the	the	DET
fnp-3049	474	2	creative	creative	ADJ
fnp-3049	474	3	commons	common	NOUN
fnp-3049	474	4	public	public	ADJ
fnp-3049	474	5	domain	domain	NOUN
fnp-3049	474	6	dedication	dedication	NOUN
fnp-3049	474	7	waiver	waiver	NOUN
fnp-3049	474	8	(	(	PUNCT
fnp-3049	474	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-3049	474	10	)	)	PUNCT
fnp-3049	474	11	applies	apply	VERB
fnp-3049	474	12	to	to	ADP
fnp-3049	474	13	the	the	DET
fnp-3049	474	14	data	datum	NOUN
fnp-3049	474	15	made	make	VERB
fnp-3049	474	16	available	available	ADJ
fnp-3049	474	17	in	in	ADP
fnp-3049	474	18	this	this	DET
fnp-3049	474	19	article	article	NOUN
fnp-3049	474	20	,	,	PUNCT
fnp-3049	474	21	unless	unless	SCONJ
fnp-3049	474	22	otherwise	otherwise	ADV
fnp-3049	474	23	stated	state	VERB
fnp-3049	474	24	.	.	PUNCT