id	sid	tid	token	lemma	pos
fnp-3341	1	1	the	the	DET
fnp-3341	1	2	neurovascular	neurovascular	ADJ
fnp-3341	1	3	unit	unit	NOUN
fnp-3341	1	4	in	in	ADP
fnp-3341	1	5	diffuse	diffuse	NOUN
fnp-3341	1	6	intrinsic	intrinsic	ADJ
fnp-3341	1	7	pontine	pontine	ADJ
fnp-3341	1	8	gliomas	glioma	NOUN
fnp-3341	1	9	feel	feel	VERB
fnp-3341	1	10	free	free	ADJ
fnp-3341	1	11	to	to	PART
fnp-3341	1	12	add	add	VERB
fnp-3341	1	13	comments	comment	NOUN
fnp-3341	1	14	by	by	ADP
fnp-3341	1	15	clicking	click	VERB
fnp-3341	1	16	these	these	DET
fnp-3341	1	17	icons	icon	NOUN
fnp-3341	1	18	on	on	ADP
fnp-3341	1	19	the	the	DET
fnp-3341	1	20	sidebar	sidebar	NOUN
fnp-3341	1	21	free	free	ADJ
fnp-3341	1	22	neuropathology	neuropathology	NOUN
fnp-3341	1	23	2:17	2:17	NUM
fnp-3341	1	24	(	(	PUNCT
fnp-3341	1	25	2021	2021	NUM
fnp-3341	1	26	)	)	PUNCT
fnp-3341	1	27	original	original	ADJ
fnp-3341	1	28	paper	paper	NOUN
fnp-3341	1	29	the	the	DET
fnp-3341	1	30	neurovascular	neurovascular	ADJ
fnp-3341	1	31	unit	unit	NOUN
fnp-3341	1	32	in	in	ADP
fnp-3341	1	33	diffuse	diffuse	NOUN
fnp-3341	1	34	intrinsic	intrinsic	ADJ
fnp-3341	1	35	pontine	pontine	ADJ
fnp-3341	1	36	gliomas	glioma	NOUN
fnp-3341	1	37	fatma	fatma	PROPN
fnp-3341	1	38	e.	e.	PROPN
fnp-3341	1	39	el	el	PROPN
fnp-3341	1	40	-	-	PUNCT
fnp-3341	1	41	khouly1,2	khouly1,2	PROPN
fnp-3341	1	42	*	*	PROPN
fnp-3341	1	43	,	,	PUNCT
fnp-3341	1	44	rianne	rianne	PROPN
fnp-3341	1	45	haumann1,2	haumann1,2	PROPN
fnp-3341	1	46	*	*	PROPN
fnp-3341	1	47	,	,	PUNCT
fnp-3341	1	48	marjolein	marjolein	PROPN
fnp-3341	1	49	breur3	breur3	PROPN
fnp-3341	1	50	,	,	PUNCT
fnp-3341	1	51	sophie	sophie	PROPN
fnp-3341	1	52	e.m	e.m	PROPN
fnp-3341	1	53	.	.	PROPN
fnp-3341	1	54	veldhuijzen	veldhuijzen	PROPN
fnp-3341	1	55	van	van	PROPN
fnp-3341	1	56	zanten1,2	zanten1,2	PROPN
fnp-3341	1	57	,	,	PUNCT
fnp-3341	1	58	gertjan	gertjan	PROPN
fnp-3341	1	59	j.l	j.l	PROPN
fnp-3341	1	60	.	.	PUNCT
fnp-3341	2	1	kaspers1,2	kaspers1,2	PROPN
fnp-3341	2	2	,	,	PUNCT
fnp-3341	2	3	n.	n.	PROPN
fnp-3341	2	4	harry	harry	PROPN
fnp-3341	2	5	hendrikse4,5	hendrikse4,5	PROPN
fnp-3341	2	6	,	,	PUNCT
fnp-3341	2	7	esther	esther	PROPN
fnp-3341	2	8	hulleman1,2	hulleman1,2	PROPN
fnp-3341	2	9	,	,	PUNCT
fnp-3341	2	10	dannis	dannis	PROPN
fnp-3341	2	11	g.	g.	PROPN
fnp-3341	2	12	van	van	PROPN
fnp-3341	2	13	vuurden1,2	vuurden1,2	PROPN
fnp-3341	2	14	#	#	SYM
fnp-3341	2	15	,	,	PUNCT
fnp-3341	2	16	marianna	marianna	PROPN
fnp-3341	2	17	bugiani3	bugiani3	PROPN
fnp-3341	2	18	#	#	NOUN
fnp-3341	2	19	1	1	NUM
fnp-3341	2	20	emma	emma	PROPN
fnp-3341	2	21	children	children	PROPN
fnp-3341	2	22	’s	’s	PART
fnp-3341	2	23	hospital	hospital	NOUN
fnp-3341	2	24	,	,	PUNCT
fnp-3341	2	25	amsterdam	amsterdam	PROPN
fnp-3341	2	26	umc	umc	PROPN
fnp-3341	2	27	–	–	PUNCT
fnp-3341	2	28	location	location	NOUN
fnp-3341	2	29	vumc	vumc	NOUN
fnp-3341	2	30	,	,	PUNCT
fnp-3341	2	31	department	department	NOUN
fnp-3341	2	32	of	of	ADP
fnp-3341	2	33	pediatric	pediatric	ADJ
fnp-3341	2	34	oncology	oncology	NOUN
fnp-3341	2	35	,	,	PUNCT
fnp-3341	2	36	cancer	cancer	NOUN
fnp-3341	2	37	center	center	NOUN
fnp-3341	2	38	amsterdam	amsterdam	PROPN
fnp-3341	2	39	,	,	PUNCT
fnp-3341	2	40	de	de	X
fnp-3341	2	41	boelelaan	boelelaan	NOUN
fnp-3341	2	42	1117	1117	NUM
fnp-3341	2	43	,	,	PUNCT
fnp-3341	2	44	amsterdam	amsterdam	PROPN
fnp-3341	2	45	,	,	PUNCT
fnp-3341	2	46	the	the	DET
fnp-3341	2	47	netherlands	netherlands	PROPN
fnp-3341	2	48	2	2	NUM
fnp-3341	2	49	princess	princess	NOUN
fnp-3341	2	50	máxima	máxima	NOUN
fnp-3341	2	51	center	center	NOUN
fnp-3341	2	52	for	for	ADP
fnp-3341	2	53	pediatric	pediatric	ADJ
fnp-3341	2	54	oncology	oncology	NOUN
fnp-3341	2	55	,	,	PUNCT
fnp-3341	2	56	utrecht	utrecht	PROPN
fnp-3341	2	57	,	,	PUNCT
fnp-3341	2	58	the	the	DET
fnp-3341	2	59	netherlands	netherlands	PROPN
fnp-3341	2	60	3	3	NUM
fnp-3341	2	61	amsterdam	amsterdam	PROPN
fnp-3341	2	62	umc	umc	PROPN
fnp-3341	2	63	–	–	PUNCT
fnp-3341	2	64	location	location	NOUN
fnp-3341	2	65	vumc	vumc	NOUN
fnp-3341	2	66	,	,	PUNCT
fnp-3341	2	67	department	department	NOUN
fnp-3341	2	68	of	of	ADP
fnp-3341	2	69	pathology	pathology	PROPN
fnp-3341	2	70	,	,	PUNCT
fnp-3341	2	71	de	de	X
fnp-3341	2	72	boelelaan	boelelaan	NOUN
fnp-3341	2	73	1117	1117	NUM
fnp-3341	2	74	,	,	PUNCT
fnp-3341	2	75	amsterdam	amsterdam	PROPN
fnp-3341	2	76	,	,	PUNCT
fnp-3341	2	77	the	the	DET
fnp-3341	2	78	netherlands	netherlands	PROPN
fnp-3341	2	79	4	4	NUM
fnp-3341	2	80	amsterdam	amsterdam	PROPN
fnp-3341	2	81	umc	umc	PROPN
fnp-3341	2	82	–	–	PUNCT
fnp-3341	2	83	location	location	NOUN
fnp-3341	2	84	vumc	vumc	NOUN
fnp-3341	2	85	,	,	PUNCT
fnp-3341	2	86	department	department	NOUN
fnp-3341	2	87	of	of	ADP
fnp-3341	2	88	clinical	clinical	ADJ
fnp-3341	2	89	pharmacology	pharmacology	NOUN
fnp-3341	2	90	&	&	CCONJ
fnp-3341	2	91	pharmacy	pharmacy	PROPN
fnp-3341	2	92	,	,	PUNCT
fnp-3341	2	93	de	de	X
fnp-3341	2	94	boelelaan	boelelaan	NOUN
fnp-3341	2	95	1117	1117	NUM
fnp-3341	2	96	,	,	PUNCT
fnp-3341	2	97	amsterdam	amsterdam	PROPN
fnp-3341	2	98	,	,	PUNCT
fnp-3341	2	99	the	the	DET
fnp-3341	2	100	netherlands	netherlands	PROPN
fnp-3341	2	101	5	5	NUM
fnp-3341	2	102	amsterdam	amsterdam	PROPN
fnp-3341	2	103	umc	umc	PROPN
fnp-3341	2	104	–	–	PUNCT
fnp-3341	2	105	location	location	NOUN
fnp-3341	2	106	vumc	vumc	NOUN
fnp-3341	2	107	,	,	PUNCT
fnp-3341	2	108	department	department	NOUN
fnp-3341	2	109	of	of	ADP
fnp-3341	2	110	radiology	radiology	NOUN
fnp-3341	2	111	&	&	CCONJ
fnp-3341	2	112	nuclear	nuclear	ADJ
fnp-3341	2	113	medicine	medicine	NOUN
fnp-3341	2	114	,	,	PUNCT
fnp-3341	2	115	de	de	X
fnp-3341	2	116	boelelaan	boelelaan	NOUN
fnp-3341	2	117	1117	1117	NUM
fnp-3341	2	118	,	,	PUNCT
fnp-3341	2	119	amsterdam	amsterdam	PROPN
fnp-3341	2	120	,	,	PUNCT
fnp-3341	2	121	the	the	DET
fnp-3341	2	122	netherlands	netherlands	PROPN
fnp-3341	2	123	*	*	PUNCT
fnp-3341	2	124	co	co	ADJ
fnp-3341	2	125	-	-	ADJ
fnp-3341	2	126	first	first	ADJ
fnp-3341	2	127	authorship	authorship	NOUN
fnp-3341	2	128	#	#	NOUN
fnp-3341	2	129	co	co	NOUN
fnp-3341	2	130	-	-	ADJ
fnp-3341	2	131	last	last	ADJ
fnp-3341	2	132	authorship	authorship	NOUN
fnp-3341	2	133	corresponding	corresponding	ADJ
fnp-3341	2	134	author	author	NOUN
fnp-3341	2	135	:	:	PUNCT
fnp-3341	2	136	fatma	fatma	PROPN
fnp-3341	2	137	e.	e.	PROPN
fnp-3341	2	138	el	el	PROPN
fnp-3341	2	139	-	-	PROPN
fnp-3341	2	140	khouly	khouly	ADV
fnp-3341	2	141	·	·	PUNCT
fnp-3341	2	142	amsterdam	amsterdam	PROPN
fnp-3341	2	143	umc	umc	PROPN
fnp-3341	2	144	,	,	PUNCT
fnp-3341	2	145	location	location	NOUN
fnp-3341	2	146	vumc	vumc	NOUN
fnp-3341	2	147	·	·	PUNCT
fnp-3341	2	148	department	department	NOUN
fnp-3341	2	149	of	of	ADP
fnp-3341	2	150	pediatric	pediatric	ADJ
fnp-3341	2	151	oncology	oncology	NOUN
fnp-3341	2	152	/	/	SYM
fnp-3341	2	153	hematology	hematology	NOUN
fnp-3341	2	154	·	·	PUNCT
fnp-3341	2	155	de	de	X
fnp-3341	2	156	boelelaan	boelelaan	PROPN
fnp-3341	2	157	1117	1117	NUM
fnp-3341	2	158	·	·	SYM
fnp-3341	2	159	1081	1081	NUM
fnp-3341	2	160	hv	hv	PROPN
fnp-3341	2	161	amsterdam	amsterdam	PROPN
fnp-3341	2	162	·	·	PUNCT
fnp-3341	2	163	the	the	DET
fnp-3341	2	164	netherlands	netherlands	PROPN
fnp-3341	2	165	f.el-khouly@amsterdamumc.nl	f.el-khouly@amsterdamumc.nl	PROPN
fnp-3341	2	166	submitted	submit	VERB
fnp-3341	2	167	:	:	PUNCT
fnp-3341	2	168	24	24	NUM
fnp-3341	2	169	april	april	PROPN
fnp-3341	2	170	2021	2021	NUM
fnp-3341	2	171	accepted	accept	VERB
fnp-3341	2	172	:	:	PUNCT
fnp-3341	2	173	27	27	NUM
fnp-3341	2	174	june	june	PROPN
fnp-3341	2	175	2021	2021	NUM
fnp-3341	2	176	copyedited	copyedit	VERB
fnp-3341	2	177	by	by	ADP
fnp-3341	2	178	:	:	PUNCT
fnp-3341	2	179	bert	bert	PROPN
fnp-3341	2	180	m.	m.	PROPN
fnp-3341	2	181	verheijen	verheijen	PROPN
fnp-3341	2	182	published	publish	VERB
fnp-3341	2	183	:	:	PUNCT
fnp-3341	2	184	5	5	NUM
fnp-3341	2	185	july	july	NOUN
fnp-3341	2	186	2021	2021	NUM
fnp-3341	2	187	https://doi.org/10.17879/freeneuropathology-2021-3341	https://doi.org/10.17879/freeneuropathology-2021-3341	VERB
fnp-3341	2	188	additional	additional	ADJ
fnp-3341	2	189	resources	resource	NOUN
fnp-3341	2	190	and	and	CCONJ
fnp-3341	2	191	electronic	electronic	ADJ
fnp-3341	2	192	supplementary	supplementary	ADJ
fnp-3341	2	193	material	material	NOUN
fnp-3341	2	194	:	:	PUNCT
fnp-3341	2	195	supplementary	supplementary	ADJ
fnp-3341	2	196	material	material	NOUN
fnp-3341	2	197	keywords	keyword	NOUN
fnp-3341	2	198	:	:	PUNCT
fnp-3341	2	199	diffuse	diffuse	VERB
fnp-3341	2	200	intrinsic	intrinsic	ADJ
fnp-3341	2	201	pontine	pontine	ADJ
fnp-3341	2	202	glioma	glioma	NOUN
fnp-3341	2	203	(	(	PUNCT
fnp-3341	2	204	dipg	dipg	PROPN
fnp-3341	2	205	)	)	PUNCT
fnp-3341	2	206	,	,	PUNCT
fnp-3341	2	207	neurovascular	neurovascular	ADJ
fnp-3341	2	208	unit	unit	NOUN
fnp-3341	2	209	(	(	PUNCT
fnp-3341	2	210	nvu	nvu	NOUN
fnp-3341	2	211	)	)	PUNCT
fnp-3341	2	212	,	,	PUNCT
fnp-3341	2	213	blood	blood	NOUN
fnp-3341	2	214	-	-	PUNCT
fnp-3341	2	215	brain	brain	NOUN
fnp-3341	2	216	barrier	barrier	NOUN
fnp-3341	2	217	(	(	PUNCT
fnp-3341	2	218	bbb	bbb	PROPN
fnp-3341	2	219	)	)	PUNCT
fnp-3341	2	220	,	,	PUNCT
fnp-3341	2	221	tight	tight	ADJ
fnp-3341	2	222	junctions	junction	NOUN
fnp-3341	2	223	,	,	PUNCT
fnp-3341	2	224	brainstem	brainstem	NOUN
fnp-3341	2	225	,	,	PUNCT
fnp-3341	2	226	pons	pon	NOUN
fnp-3341	2	227	abstract	abstract	ADJ
fnp-3341	2	228	aims	aim	NOUN
fnp-3341	2	229	:	:	PUNCT
fnp-3341	2	230	diffuse	diffuse	VERB
fnp-3341	2	231	intrinsic	intrinsic	ADJ
fnp-3341	2	232	pontine	pontine	ADJ
fnp-3341	2	233	glioma	glioma	NOUN
fnp-3341	2	234	(	(	PUNCT
fnp-3341	2	235	dipg	dipg	PROPN
fnp-3341	2	236	)	)	PUNCT
fnp-3341	2	237	is	be	AUX
fnp-3341	2	238	a	a	DET
fnp-3341	2	239	childhood	childhood	NOUN
fnp-3341	2	240	brainstem	brainstem	NOUN
fnp-3341	2	241	tumor	tumor	NOUN
fnp-3341	2	242	with	with	ADP
fnp-3341	2	243	a	a	DET
fnp-3341	2	244	median	median	ADJ
fnp-3341	2	245	overall	overall	ADJ
fnp-3341	2	246	survival	survival	NOUN
fnp-3341	2	247	of	of	ADP
fnp-3341	2	248	eleven	eleven	NUM
fnp-3341	2	249	months	month	NOUN
fnp-3341	2	250	.	.	PUNCT
fnp-3341	3	1	lack	lack	NOUN
fnp-3341	3	2	of	of	ADP
fnp-3341	3	3	chemotherapy	chemotherapy	NOUN
fnp-3341	3	4	efficacy	efficacy	NOUN
fnp-3341	3	5	may	may	AUX
fnp-3341	3	6	be	be	AUX
fnp-3341	3	7	related	relate	VERB
fnp-3341	3	8	to	to	ADP
fnp-3341	3	9	an	an	DET
fnp-3341	3	10	intact	intact	ADJ
fnp-3341	3	11	blood	blood	NOUN
fnp-3341	3	12	-	-	PUNCT
fnp-3341	3	13	brain	brain	NOUN
fnp-3341	3	14	barrier	barrier	NOUN
fnp-3341	3	15	(	(	PUNCT
fnp-3341	3	16	bbb	bbb	NOUN
fnp-3341	3	17	)	)	PUNCT
fnp-3341	3	18	.	.	PUNCT
fnp-3341	4	1	in	in	ADP
fnp-3341	4	2	this	this	DET
fnp-3341	4	3	study	study	NOUN
fnp-3341	4	4	we	we	PRON
fnp-3341	4	5	aim	aim	VERB
fnp-3341	4	6	to	to	PART
fnp-3341	4	7	investigate	investigate	VERB
fnp-3341	4	8	the	the	DET
fnp-3341	4	9	neurovascular	neurovascular	ADJ
fnp-3341	4	10	unit	unit	NOUN
fnp-3341	4	11	(	(	PUNCT
fnp-3341	4	12	nvu	nvu	NOUN
fnp-3341	4	13	)	)	PUNCT
fnp-3341	4	14	in	in	ADP
fnp-3341	4	15	dipg	dipg	NOUN
fnp-3341	4	16	patients	patient	NOUN
fnp-3341	4	17	.	.	PUNCT
fnp-3341	5	1	methods	method	NOUN
fnp-3341	5	2	:	:	PUNCT
fnp-3341	5	3	dipg	dipg	PROPN
fnp-3341	5	4	biopsy	biopsy	PROPN
fnp-3341	5	5	(	(	PUNCT
fnp-3341	5	6	n	n	NOUN
fnp-3341	5	7	=	=	SYM
fnp-3341	5	8	4	4	NUM
fnp-3341	5	9	)	)	PUNCT
fnp-3341	5	10	and	and	CCONJ
fnp-3341	5	11	autopsy	autopsy	ADJ
fnp-3341	5	12	samples	sample	NOUN
fnp-3341	5	13	(	(	PUNCT
fnp-3341	5	14	n	n	NOUN
fnp-3341	5	15	=	=	SYM
fnp-3341	5	16	6	6	NUM
fnp-3341	5	17	)	)	PUNCT
fnp-3341	5	18	and	and	CCONJ
fnp-3341	5	19	age	age	NOUN
fnp-3341	5	20	-	-	PUNCT
fnp-3341	5	21	matched	match	VERB
fnp-3341	5	22	healthy	healthy	ADJ
fnp-3341	5	23	pons	pon	NOUN
fnp-3341	5	24	samples	sample	NOUN
fnp-3341	5	25	(	(	PUNCT
fnp-3341	5	26	n	n	NOUN
fnp-3341	5	27	=	=	SYM
fnp-3341	5	28	20	20	NUM
fnp-3341	5	29	)	)	PUNCT
fnp-3341	5	30	were	be	AUX
fnp-3341	5	31	immunohistochemically	immunohistochemically	ADV
fnp-3341	5	32	investigated	investigate	VERB
fnp-3341	5	33	for	for	ADP
fnp-3341	5	34	plasma	plasma	NOUN
fnp-3341	5	35	protein	protein	NOUN
fnp-3341	5	36	extravasation	extravasation	NOUN
fnp-3341	5	37	,	,	PUNCT
fnp-3341	5	38	and	and	CCONJ
fnp-3341	5	39	the	the	DET
fnp-3341	5	40	expression	expression	NOUN
fnp-3341	5	41	of	of	ADP
fnp-3341	5	42	tight	tight	ADJ
fnp-3341	5	43	junction	junction	NOUN
fnp-3341	5	44	proteins	protein	NOUN
fnp-3341	5	45	claudin-5	claudin-5	PRON
fnp-3341	5	46	and	and	CCONJ
fnp-3341	5	47	zonula	zonula	NOUN
fnp-3341	5	48	occludens-1	occludens-1	NUM
fnp-3341	5	49	(	(	PUNCT
fnp-3341	5	50	zo-1	zo-1	NUM
fnp-3341	5	51	)	)	PUNCT
fnp-3341	5	52	,	,	PUNCT
fnp-3341	5	53	basement	basement	NOUN
fnp-3341	5	54	membrane	membrane	NOUN
fnp-3341	5	55	component	component	NOUN
fnp-3341	5	56	laminin	laminin	NOUN
fnp-3341	5	57	,	,	PUNCT
fnp-3341	5	58	pericyte	pericyte	NOUN
fnp-3341	5	59	marker	marker	NOUN
fnp-3341	5	60	pdgfr	pdgfr	NOUN
fnp-3341	5	61	-	-	PUNCT
fnp-3341	5	62	β	β	NOUN
fnp-3341	5	63	,	,	PUNCT
fnp-3341	5	64	and	and	CCONJ
fnp-3341	5	65	efflux	efflux	VERB
fnp-3341	5	66	transporters	transporter	NOUN
fnp-3341	5	67	p	p	NOUN
fnp-3341	5	68	-	-	PUNCT
fnp-3341	5	69	gp	gp	NOUN
fnp-3341	5	70	and	and	CCONJ
fnp-3341	5	71	bcrp	bcrp	ADV
fnp-3341	5	72	.	.	PUNCT
fnp-3341	6	1	the	the	DET
fnp-3341	6	2	mean	mean	ADJ
fnp-3341	6	3	vascular	vascular	ADJ
fnp-3341	6	4	density	density	NOUN
fnp-3341	6	5	and	and	CCONJ
fnp-3341	6	6	diameter	diameter	NOUN
fnp-3341	6	7	were	be	AUX
fnp-3341	6	8	also	also	ADV
fnp-3341	6	9	assessed	assess	VERB
fnp-3341	6	10	.	.	PUNCT
fnp-3341	7	1	results	result	NOUN
fnp-3341	7	2	:	:	PUNCT
fnp-3341	7	3	dipgs	dipgs	PROPN
fnp-3341	7	4	show	show	VERB
fnp-3341	7	5	a	a	DET
fnp-3341	7	6	heterogeneity	heterogeneity	NOUN
fnp-3341	7	7	in	in	ADP
fnp-3341	7	8	cell	cell	NOUN
fnp-3341	7	9	morphology	morphology	NOUN
fnp-3341	7	10	and	and	CCONJ
fnp-3341	7	11	evidence	evidence	NOUN
fnp-3341	7	12	of	of	ADP
fnp-3341	7	13	bbb	bbb	PROPN
fnp-3341	7	14	leakage	leakage	NOUN
fnp-3341	7	15	.	.	PUNCT
fnp-3341	8	1	both	both	PRON
fnp-3341	8	2	in	in	ADP
fnp-3341	8	3	tumor	tumor	NOUN
fnp-3341	8	4	biopsy	biopsy	NOUN
fnp-3341	8	5	and	and	CCONJ
fnp-3341	8	6	autopsy	autopsy	ADJ
fnp-3341	8	7	samples	sample	NOUN
fnp-3341	8	8	,	,	PUNCT
fnp-3341	8	9	expression	expression	NOUN
fnp-3341	8	10	of	of	ADP
fnp-3341	8	11	claudin-5	claudin-5	PROPN
fnp-3341	8	12	,	,	PUNCT
fnp-3341	8	13	zo-1	zo-1	PRON
fnp-3341	8	14	,	,	PUNCT
fnp-3341	8	15	laminin	laminin	NOUN
fnp-3341	8	16	,	,	PUNCT
fnp-3341	8	17	pdgfr	pdgfr	NOUN
fnp-3341	8	18	-	-	PUNCT
fnp-3341	8	19	β	β	X
fnp-3341	8	20	and	and	CCONJ
fnp-3341	8	21	p	p	X
fnp-3341	8	22	-	-	PUNCT
fnp-3341	8	23	gp	gp	NOUN
fnp-3341	8	24	was	be	AUX
fnp-3341	8	25	reduced	reduce	VERB
fnp-3341	8	26	compared	compare	VERB
fnp-3341	8	27	to	to	ADP
fnp-3341	8	28	healthy	healthy	ADJ
fnp-3341	8	29	pontine	pontine	ADJ
fnp-3341	8	30	tissues	tissue	NOUN
fnp-3341	8	31	.	.	PUNCT
fnp-3341	9	1	in	in	ADP
fnp-3341	9	2	dipg	dipg	PROPN
fnp-3341	9	3	autopsy	autopsy	ADJ
fnp-3341	9	4	samples	sample	NOUN
fnp-3341	9	5	,	,	PUNCT
fnp-3341	9	6	vascular	vascular	ADJ
fnp-3341	9	7	density	density	NOUN
fnp-3341	9	8	was	be	AUX
fnp-3341	9	9	lower	low	ADJ
fnp-3341	9	10	compared	compare	VERB
fnp-3341	9	11	to	to	ADP
fnp-3341	9	12	healthy	healthy	ADJ
fnp-3341	9	13	pons	pon	NOUN
fnp-3341	9	14	.	.	PUNCT
fnp-3341	10	1	the	the	DET
fnp-3341	10	2	density	density	NOUN
fnp-3341	10	3	of	of	ADP
fnp-3341	10	4	small	small	ADJ
fnp-3341	10	5	vessels	vessel	NOUN
fnp-3341	10	6	(	(	PUNCT
fnp-3341	10	7	<	<	X
fnp-3341	10	8	10	10	NUM
fnp-3341	10	9	µm	µm	NOUN
fnp-3341	10	10	)	)	PUNCT
fnp-3341	10	11	was	be	AUX
fnp-3341	10	12	significantly	significantly	ADV
fnp-3341	10	13	lower	low	ADJ
fnp-3341	10	14	(	(	PUNCT
fnp-3341	10	15	p<0.001	p<0.001	ADJ
fnp-3341	10	16	)	)	PUNCT
fnp-3341	10	17	,	,	PUNCT
fnp-3341	10	18	whereas	whereas	SCONJ
fnp-3341	10	19	the	the	DET
fnp-3341	10	20	density	density	NOUN
fnp-3341	10	21	of	of	ADP
fnp-3341	10	22	large	large	ADJ
fnp-3341	10	23	vessels	vessel	NOUN
fnp-3341	10	24	(	(	PUNCT
fnp-3341	10	25	≥10	≥10	ADJ
fnp-3341	10	26	µm	µm	NOUN
fnp-3341	10	27	)	)	PUNCT
fnp-3341	10	28	did	do	AUX
fnp-3341	10	29	not	not	PART
fnp-3341	10	30	differ	differ	VERB
fnp-3341	10	31	between	between	ADP
fnp-3341	10	32	groups	group	NOUN
fnp-3341	10	33	(	(	PUNCT
fnp-3341	10	34	p	p	X
fnp-3341	10	35	=	=	NOUN
fnp-3341	10	36	0.404	0.404	NUM
fnp-3341	10	37	)	)	PUNCT
fnp-3341	10	38	.	.	PUNCT
fnp-3341	11	1	the	the	DET
fnp-3341	11	2	median	median	ADJ
fnp-3341	11	3	vascular	vascular	ADJ
fnp-3341	11	4	diameter	diameter	NOUN
fnp-3341	11	5	was	be	AUX
fnp-3341	11	6	not	not	PART
fnp-3341	11	7	significantly	significantly	ADV
fnp-3341	11	8	different	different	ADJ
fnp-3341	11	9	:	:	PUNCT
fnp-3341	11	10	6.21	6.21	NUM
fnp-3341	11	11	µm	µm	NOUN
fnp-3341	11	12	in	in	ADP
fnp-3341	11	13	dipg	dipg	NOUN
fnp-3341	11	14	autopsy	autopsy	ADJ
fnp-3341	11	15	samples	sample	NOUN
fnp-3341	11	16	(	(	PUNCT
fnp-3341	11	17	range	range	NOUN
fnp-3341	11	18	2.25	2.25	NUM
fnp-3341	11	19	-	-	SYM
fnp-3341	11	20	94.85	94.85	NUM
fnp-3341	11	21	µm	µm	NOUN
fnp-3341	11	22	)	)	PUNCT
fnp-3341	11	23	,	,	PUNCT
fnp-3341	11	24	and	and	CCONJ
fnp-3341	11	25	6.26	6.26	NUM
fnp-3341	11	26	µm	µm	NOUN
fnp-3341	11	27	in	in	ADP
fnp-3341	11	28	controls	control	NOUN
fnp-3341	11	29	(	(	PUNCT
fnp-3341	11	30	range	range	NOUN
fnp-3341	11	31	1.17	1.17	NUM
fnp-3341	11	32	-	-	SYM
fnp-3341	11	33	264.77	264.77	NUM
fnp-3341	11	34	µm	µm	NOUN
fnp-3341	11	35	)	)	PUNCT
fnp-3341	11	36	.	.	PUNCT
fnp-3341	12	1	conclusion	conclusion	NOUN
fnp-3341	12	2	:	:	PUNCT
fnp-3341	12	3	our	our	PRON
fnp-3341	12	4	study	study	NOUN
fnp-3341	12	5	demonstrates	demonstrate	VERB
fnp-3341	12	6	evidence	evidence	NOUN
fnp-3341	12	7	of	of	ADP
fnp-3341	12	8	structural	structural	ADJ
fnp-3341	12	9	changes	change	NOUN
fnp-3341	12	10	in	in	ADP
fnp-3341	12	11	the	the	DET
fnp-3341	12	12	nvu	nvu	NOUN
fnp-3341	12	13	in	in	ADP
fnp-3341	12	14	dipg	dipg	NOUN
fnp-3341	12	15	patients	patient	NOUN
fnp-3341	12	16	,	,	PUNCT
fnp-3341	12	17	both	both	CCONJ
fnp-3341	12	18	in	in	ADP
fnp-3341	12	19	biopsy	biopsy	NOUN
fnp-3341	12	20	and	and	CCONJ
fnp-3341	12	21	autopsy	autopsy	ADJ
fnp-3341	12	22	samples	sample	NOUN
fnp-3341	12	23	,	,	PUNCT
fnp-3341	12	24	as	as	ADV
fnp-3341	12	25	well	well	ADV
fnp-3341	12	26	as	as	ADP
fnp-3341	12	27	a	a	DET
fnp-3341	12	28	reduced	reduced	ADJ
fnp-3341	12	29	vascular	vascular	ADJ
fnp-3341	12	30	density	density	NOUN
fnp-3341	12	31	in	in	ADP
fnp-3341	12	32	end	end	NOUN
fnp-3341	12	33	-	-	PUNCT
fnp-3341	12	34	stage	stage	NOUN
fnp-3341	12	35	disease	disease	NOUN
fnp-3341	12	36	.	.	PUNCT
fnp-3341	13	1	adding	add	VERB
fnp-3341	13	2	such	such	DET
fnp-3341	13	3	a	a	DET
fnp-3341	13	4	biological	biological	ADJ
fnp-3341	13	5	perspective	perspective	NOUN
fnp-3341	13	6	may	may	AUX
fnp-3341	13	7	help	help	VERB
fnp-3341	13	8	to	to	PART
fnp-3341	13	9	better	well	ADV
fnp-3341	13	10	direct	direct	VERB
fnp-3341	13	11	future	future	ADJ
fnp-3341	13	12	treatment	treatment	NOUN
fnp-3341	13	13	choices	choice	NOUN
fnp-3341	13	14	for	for	ADP
fnp-3341	13	15	dipg	dipg	NOUN
fnp-3341	13	16	patients	patient	NOUN
fnp-3341	13	17	.	.	PUNCT
fnp-3341	14	1	introduction	introduction	NOUN
fnp-3341	14	2	diffuse	diffuse	VERB
fnp-3341	14	3	intrinsic	intrinsic	ADJ
fnp-3341	14	4	pontine	pontine	ADJ
fnp-3341	14	5	gliomas	glioma	NOUN
fnp-3341	14	6	(	(	PUNCT
fnp-3341	14	7	dipgs	dipgs	NOUN
fnp-3341	14	8	)	)	PUNCT
fnp-3341	14	9	are	be	AUX
fnp-3341	14	10	rare	rare	ADJ
fnp-3341	14	11	and	and	CCONJ
fnp-3341	14	12	aggressive	aggressive	ADJ
fnp-3341	14	13	childhood	childhood	NOUN
fnp-3341	14	14	malignancies	malignancy	NOUN
fnp-3341	14	15	of	of	ADP
fnp-3341	14	16	the	the	DET
fnp-3341	14	17	brainstem	brainstem	NOUN
fnp-3341	14	18	.	.	PUNCT
fnp-3341	15	1	these	these	DET
fnp-3341	15	2	tumors	tumor	NOUN
fnp-3341	15	3	are	be	AUX
fnp-3341	15	4	characterized	characterize	VERB
fnp-3341	15	5	by	by	ADP
fnp-3341	15	6	a	a	DET
fnp-3341	15	7	diffuse	diffuse	NOUN
fnp-3341	15	8	growth	growth	NOUN
fnp-3341	15	9	pattern	pattern	NOUN
fnp-3341	15	10	closely	closely	ADV
fnp-3341	15	11	interwoven	interweave	VERB
fnp-3341	15	12	within	within	ADP
fnp-3341	15	13	white	white	ADJ
fnp-3341	15	14	matter	matter	NOUN
fnp-3341	15	15	tracts	tract	NOUN
fnp-3341	15	16	and	and	CCONJ
fnp-3341	15	17	grey	grey	ADJ
fnp-3341	15	18	matter	matter	NOUN
fnp-3341	15	19	structures	structure	NOUN
fnp-3341	15	20	,	,	PUNCT
fnp-3341	15	21	and	and	CCONJ
fnp-3341	15	22	an	an	DET
fnp-3341	15	23	intrinsic	intrinsic	ADJ
fnp-3341	15	24	nature	nature	NOUN
fnp-3341	15	25	,	,	PUNCT
fnp-3341	15	26	uttered	utter	VERB
fnp-3341	15	27	by	by	ADP
fnp-3341	15	28	hypertrophy	hypertrophy	NOUN
fnp-3341	15	29	of	of	ADP
fnp-3341	15	30	the	the	DET
fnp-3341	15	31	brainstem	brainstem	NOUN
fnp-3341	15	32	often	often	ADV
fnp-3341	15	33	encasing	encase	VERB
fnp-3341	15	34	the	the	DET
fnp-3341	15	35	basilar	basilar	ADJ
fnp-3341	15	36	artery	artery	NOUN
fnp-3341	15	37	1,2	1,2	NUM
fnp-3341	15	38	.	.	PUNCT
fnp-3341	16	1	with	with	ADP
fnp-3341	16	2	a	a	DET
fnp-3341	16	3	median	median	ADJ
fnp-3341	16	4	overall	overall	ADJ
fnp-3341	16	5	survival	survival	NOUN
fnp-3341	16	6	of	of	ADP
fnp-3341	16	7	eleven	eleven	NUM
fnp-3341	16	8	months	month	NOUN
fnp-3341	16	9	,	,	PUNCT
fnp-3341	16	10	and	and	CCONJ
fnp-3341	16	11	a	a	DET
fnp-3341	16	12	two	two	NUM
fnp-3341	16	13	-	-	PUNCT
fnp-3341	16	14	year	year	NOUN
fnp-3341	16	15	survival	survival	NOUN
fnp-3341	16	16	rate	rate	NOUN
fnp-3341	16	17	of	of	ADP
fnp-3341	16	18	10	10	NUM
fnp-3341	16	19	%	%	NOUN
fnp-3341	16	20	,	,	PUNCT
fnp-3341	16	21	dipgs	dipgs	PROPN
fnp-3341	16	22	are	be	AUX
fnp-3341	16	23	the	the	DET
fnp-3341	16	24	leading	lead	VERB
fnp-3341	16	25	cause	cause	NOUN
fnp-3341	16	26	of	of	ADP
fnp-3341	16	27	brain	brain	NOUN
fnp-3341	16	28	tumor	tumor	NOUN
fnp-3341	16	29	-	-	PUNCT
fnp-3341	16	30	related	relate	VERB
fnp-3341	16	31	deaths	death	NOUN
fnp-3341	16	32	in	in	ADP
fnp-3341	16	33	children	child	NOUN
fnp-3341	16	34	3	3	NUM
fnp-3341	16	35	-	-	SYM
fnp-3341	16	36	7	7	NUM
fnp-3341	16	37	.	.	PUNCT
fnp-3341	17	1	in	in	ADP
fnp-3341	17	2	the	the	DET
fnp-3341	17	3	recent	recent	ADJ
fnp-3341	17	4	world	world	NOUN
fnp-3341	17	5	health	health	NOUN
fnp-3341	17	6	organization	organization	NOUN
fnp-3341	17	7	(	(	PUNCT
fnp-3341	17	8	who	who	PRON
fnp-3341	17	9	)	)	PUNCT
fnp-3341	17	10	classification	classification	NOUN
fnp-3341	17	11	of	of	ADP
fnp-3341	17	12	tumors	tumor	NOUN
fnp-3341	17	13	of	of	ADP
fnp-3341	17	14	the	the	DET
fnp-3341	17	15	central	central	ADJ
fnp-3341	17	16	nervous	nervous	ADJ
fnp-3341	17	17	system	system	NOUN
fnp-3341	17	18	(	(	PUNCT
fnp-3341	17	19	cns	cns	NOUN
fnp-3341	17	20	)	)	PUNCT
fnp-3341	17	21	,	,	PUNCT
fnp-3341	17	22	dipgs	dipgs	NOUN
fnp-3341	17	23	were	be	AUX
fnp-3341	17	24	reclassified	reclassify	VERB
fnp-3341	17	25	as	as	ADP
fnp-3341	17	26	h3k27	h3k27	NOUN
fnp-3341	17	27	m	m	VERB
fnp-3341	17	28	mutated	mutate	VERB
fnp-3341	17	29	diffuse	diffuse	ADJ
fnp-3341	17	30	midline	midline	NOUN
fnp-3341	17	31	gliomas	glioma	NOUN
fnp-3341	17	32	(	(	PUNCT
fnp-3341	17	33	dmg	dmg	VERB
fnp-3341	17	34	h3k27	h3k27	PROPN
fnp-3341	17	35	m	m	NOUN
fnp-3341	17	36	)	)	PUNCT
fnp-3341	17	37	8	8	NUM
fnp-3341	17	38	.	.	PUNCT
fnp-3341	18	1	though	though	SCONJ
fnp-3341	18	2	much	much	ADJ
fnp-3341	18	3	research	research	NOUN
fnp-3341	18	4	has	have	AUX
fnp-3341	18	5	been	be	AUX
fnp-3341	18	6	dedicated	dedicate	VERB
fnp-3341	18	7	to	to	ADP
fnp-3341	18	8	dipg	dipg	PROPN
fnp-3341	18	9	,	,	PUNCT
fnp-3341	18	10	its	its	PRON
fnp-3341	18	11	poor	poor	ADJ
fnp-3341	18	12	outcome	outcome	NOUN
fnp-3341	18	13	has	have	AUX
fnp-3341	18	14	remained	remain	VERB
fnp-3341	18	15	unchanged	unchanged	ADJ
fnp-3341	18	16	for	for	ADP
fnp-3341	18	17	the	the	DET
fnp-3341	18	18	past	past	ADJ
fnp-3341	18	19	40	40	NUM
fnp-3341	18	20	years	year	NOUN
fnp-3341	18	21	9	9	NUM
fnp-3341	18	22	.	.	PUNCT
fnp-3341	18	23	to	to	ADP
fnp-3341	18	24	date	date	NOUN
fnp-3341	18	25	,	,	PUNCT
fnp-3341	18	26	radiotherapy	radiotherapy	NOUN
fnp-3341	18	27	remains	remain	VERB
fnp-3341	18	28	the	the	DET
fnp-3341	18	29	only	only	ADV
fnp-3341	18	30	(	(	PUNCT
fnp-3341	18	31	temporarily	temporarily	ADV
fnp-3341	18	32	)	)	PUNCT
fnp-3341	18	33	effective	effective	ADJ
fnp-3341	18	34	,	,	PUNCT
fnp-3341	18	35	albeit	albeit	SCONJ
fnp-3341	18	36	palliative	palliative	ADJ
fnp-3341	18	37	treatment	treatment	NOUN
fnp-3341	18	38	,	,	PUNCT
fnp-3341	18	39	and	and	CCONJ
fnp-3341	18	40	no	no	DET
fnp-3341	18	41	chemotherapy	chemotherapy	NOUN
fnp-3341	18	42	regimens	regimen	NOUN
fnp-3341	18	43	prolonging	prolong	VERB
fnp-3341	18	44	survival	survival	NOUN
fnp-3341	18	45	have	have	AUX
fnp-3341	18	46	been	be	AUX
fnp-3341	18	47	identified	identify	VERB
fnp-3341	18	48	yet	yet	ADV
fnp-3341	18	49	.	.	PUNCT
fnp-3341	19	1	since	since	SCONJ
fnp-3341	19	2	in	in	ADP
fnp-3341	19	3	vitro	vitro	X
fnp-3341	19	4	and	and	CCONJ
fnp-3341	19	5	in	in	ADP
fnp-3341	19	6	vivo	vivo	ADJ
fnp-3341	19	7	drug	drug	NOUN
fnp-3341	19	8	testing	testing	NOUN
fnp-3341	19	9	on	on	ADP
fnp-3341	19	10	patient	patient	NOUN
fnp-3341	19	11	-	-	PUNCT
fnp-3341	19	12	derived	derive	VERB
fnp-3341	19	13	tumor	tumor	NOUN
fnp-3341	19	14	cells	cell	NOUN
fnp-3341	19	15	has	have	AUX
fnp-3341	19	16	shown	show	VERB
fnp-3341	19	17	sensitivity	sensitivity	NOUN
fnp-3341	19	18	to	to	ADP
fnp-3341	19	19	conventional	conventional	ADJ
fnp-3341	19	20	cytotoxic	cytotoxic	ADJ
fnp-3341	19	21	agents	agent	NOUN
fnp-3341	19	22	and	and	CCONJ
fnp-3341	19	23	novel	novel	ADJ
fnp-3341	19	24	drugs	drug	NOUN
fnp-3341	19	25	,	,	PUNCT
fnp-3341	19	26	the	the	DET
fnp-3341	19	27	lack	lack	NOUN
fnp-3341	19	28	of	of	ADP
fnp-3341	19	29	efficacy	efficacy	NOUN
fnp-3341	19	30	in	in	ADP
fnp-3341	19	31	patients	patient	NOUN
fnp-3341	19	32	is	be	AUX
fnp-3341	19	33	hypothesized	hypothesize	VERB
fnp-3341	19	34	to	to	PART
fnp-3341	19	35	be	be	AUX
fnp-3341	19	36	related	relate	VERB
fnp-3341	19	37	to	to	ADP
fnp-3341	19	38	ineffective	ineffective	ADJ
fnp-3341	19	39	drug	drug	NOUN
fnp-3341	19	40	delivery	delivery	NOUN
fnp-3341	19	41	due	due	ADP
fnp-3341	19	42	to	to	ADP
fnp-3341	19	43	an	an	DET
fnp-3341	19	44	intact	intact	ADJ
fnp-3341	19	45	blood	blood	NOUN
fnp-3341	19	46	-	-	PUNCT
fnp-3341	19	47	brain	brain	NOUN
fnp-3341	19	48	barrier	barrier	NOUN
fnp-3341	19	49	(	(	PUNCT
fnp-3341	19	50	bbb	bbb	NOUN
fnp-3341	19	51	)	)	PUNCT
fnp-3341	19	52	10	10	NUM
fnp-3341	19	53	-	-	SYM
fnp-3341	19	54	12	12	NUM
fnp-3341	19	55	.	.	PUNCT
fnp-3341	20	1	the	the	DET
fnp-3341	20	2	bbb	bbb	PROPN
fnp-3341	20	3	is	be	AUX
fnp-3341	20	4	formed	form	VERB
fnp-3341	20	5	by	by	ADP
fnp-3341	20	6	endothelial	endothelial	ADJ
fnp-3341	20	7	cells	cell	NOUN
fnp-3341	20	8	interconnected	interconnect	VERB
fnp-3341	20	9	and	and	CCONJ
fnp-3341	20	10	sealed	seal	VERB
fnp-3341	20	11	by	by	ADP
fnp-3341	20	12	tight	tight	ADJ
fnp-3341	20	13	junctions	junction	NOUN
fnp-3341	20	14	.	.	PUNCT
fnp-3341	21	1	the	the	DET
fnp-3341	21	2	abluminal	abluminal	ADJ
fnp-3341	21	3	surface	surface	NOUN
fnp-3341	21	4	of	of	ADP
fnp-3341	21	5	the	the	DET
fnp-3341	21	6	endothelium	endothelium	NOUN
fnp-3341	21	7	is	be	AUX
fnp-3341	21	8	covered	cover	VERB
fnp-3341	21	9	by	by	ADP
fnp-3341	21	10	a	a	DET
fnp-3341	21	11	basement	basement	NOUN
fnp-3341	21	12	membrane	membrane	NOUN
fnp-3341	21	13	in	in	ADP
fnp-3341	21	14	which	which	PRON
fnp-3341	21	15	pericytes	pericyte	NOUN
fnp-3341	21	16	are	be	AUX
fnp-3341	21	17	embedded	embed	VERB
fnp-3341	21	18	.	.	PUNCT
fnp-3341	22	1	pericytes	pericyte	NOUN
fnp-3341	22	2	control	control	VERB
fnp-3341	22	3	the	the	DET
fnp-3341	22	4	cerebral	cerebral	ADJ
fnp-3341	22	5	blood	blood	NOUN
fnp-3341	22	6	flow	flow	NOUN
fnp-3341	22	7	by	by	ADP
fnp-3341	22	8	regulating	regulate	VERB
fnp-3341	22	9	capillary	capillary	ADJ
fnp-3341	22	10	diameter	diameter	NOUN
fnp-3341	22	11	and	and	CCONJ
fnp-3341	22	12	vessel	vessel	NOUN
fnp-3341	22	13	stability	stability	NOUN
fnp-3341	22	14	.	.	PUNCT
fnp-3341	23	1	the	the	DET
fnp-3341	23	2	basement	basement	NOUN
fnp-3341	23	3	membrane	membrane	NOUN
fnp-3341	23	4	is	be	AUX
fnp-3341	23	5	enclosed	enclose	VERB
fnp-3341	23	6	by	by	ADP
fnp-3341	23	7	astrocyte	astrocyte	NOUN
fnp-3341	23	8	end	end	NOUN
fnp-3341	23	9	-	-	PUNCT
fnp-3341	23	10	feet	foot	NOUN
fnp-3341	23	11	,	,	PUNCT
fnp-3341	23	12	also	also	ADV
fnp-3341	23	13	important	important	ADJ
fnp-3341	23	14	for	for	ADP
fnp-3341	23	15	brain	brain	NOUN
fnp-3341	23	16	homeostasis	homeostasis	NOUN
fnp-3341	23	17	.	.	PUNCT
fnp-3341	24	1	together	together	ADV
fnp-3341	24	2	,	,	PUNCT
fnp-3341	24	3	pericytes	pericyte	NOUN
fnp-3341	24	4	and	and	CCONJ
fnp-3341	24	5	astrocyte	astrocyte	NOUN
fnp-3341	24	6	end	end	NOUN
fnp-3341	24	7	-	-	PUNCT
fnp-3341	24	8	feet	foot	NOUN
fnp-3341	24	9	induce	induce	VERB
fnp-3341	24	10	and	and	CCONJ
fnp-3341	24	11	maintain	maintain	VERB
fnp-3341	24	12	the	the	DET
fnp-3341	24	13	integrity	integrity	NOUN
fnp-3341	24	14	of	of	ADP
fnp-3341	24	15	the	the	DET
fnp-3341	24	16	bbb	bbb	PROPN
fnp-3341	24	17	13,14	13,14	NUM
fnp-3341	24	18	.	.	PUNCT
fnp-3341	25	1	the	the	DET
fnp-3341	25	2	bbb	bbb	PROPN
fnp-3341	25	3	regulates	regulate	VERB
fnp-3341	25	4	transport	transport	NOUN
fnp-3341	25	5	of	of	ADP
fnp-3341	25	6	essential	essential	ADJ
fnp-3341	25	7	nutrients	nutrient	NOUN
fnp-3341	25	8	to	to	ADP
fnp-3341	25	9	the	the	DET
fnp-3341	25	10	brain	brain	NOUN
fnp-3341	25	11	through	through	ADP
fnp-3341	25	12	active	active	ADJ
fnp-3341	25	13	transport	transport	NOUN
fnp-3341	25	14	mechanisms	mechanism	NOUN
fnp-3341	25	15	,	,	PUNCT
fnp-3341	25	16	such	such	ADJ
fnp-3341	25	17	as	as	ADP
fnp-3341	25	18	glucose	glucose	NOUN
fnp-3341	25	19	transporters	transporter	NOUN
fnp-3341	25	20	of	of	ADP
fnp-3341	25	21	the	the	DET
fnp-3341	25	22	glut	glut	NOUN
fnp-3341	25	23	-	-	PUNCT
fnp-3341	25	24	family	family	NOUN
fnp-3341	25	25	.	.	PUNCT
fnp-3341	26	1	the	the	DET
fnp-3341	26	2	efflux	efflux	NOUN
fnp-3341	26	3	of	of	ADP
fnp-3341	26	4	waste	waste	NOUN
fnp-3341	26	5	products	product	NOUN
fnp-3341	26	6	and	and	CCONJ
fnp-3341	26	7	exogenous	exogenous	ADJ
fnp-3341	26	8	compounds	compound	NOUN
fnp-3341	26	9	is	be	AUX
fnp-3341	26	10	mediated	mediate	VERB
fnp-3341	26	11	through	through	ADP
fnp-3341	26	12	efflux	efflux	NOUN
fnp-3341	26	13	transporters	transporter	NOUN
fnp-3341	26	14	of	of	ADP
fnp-3341	26	15	the	the	DET
fnp-3341	26	16	atp	atp	NOUN
fnp-3341	26	17	-	-	PUNCT
fnp-3341	26	18	binding	bind	VERB
fnp-3341	26	19	cassette	cassette	NOUN
fnp-3341	26	20	family	family	NOUN
fnp-3341	26	21	(	(	PUNCT
fnp-3341	26	22	e.g.	e.g.	ADV
fnp-3341	26	23	,	,	PUNCT
fnp-3341	26	24	p	p	NOUN
fnp-3341	26	25	-	-	PUNCT
fnp-3341	26	26	gp	gp	NOUN
fnp-3341	26	27	,	,	PUNCT
fnp-3341	26	28	bcrp	bcrp	ADV
fnp-3341	26	29	,	,	PUNCT
fnp-3341	26	30	mrp-1	mrp-1	NOUN
fnp-3341	26	31	)	)	PUNCT
fnp-3341	26	32	14,15	14,15	NUM
fnp-3341	26	33	.	.	PUNCT
fnp-3341	27	1	additionally	additionally	ADV
fnp-3341	27	2	,	,	PUNCT
fnp-3341	27	3	the	the	DET
fnp-3341	27	4	paracellular	paracellular	ADJ
fnp-3341	27	5	barrier	barrier	NOUN
fnp-3341	27	6	capacities	capacity	NOUN
fnp-3341	27	7	of	of	ADP
fnp-3341	27	8	the	the	DET
fnp-3341	27	9	tight	tight	ADJ
fnp-3341	27	10	junctions	junction	NOUN
fnp-3341	27	11	limit	limit	VERB
fnp-3341	27	12	transport	transport	NOUN
fnp-3341	27	13	of	of	ADP
fnp-3341	27	14	circulating	circulate	VERB
fnp-3341	27	15	monoamines	monoamine	NOUN
fnp-3341	27	16	and	and	CCONJ
fnp-3341	27	17	drugs	drug	NOUN
fnp-3341	27	18	across	across	ADP
fnp-3341	27	19	the	the	DET
fnp-3341	27	20	bbb	bbb	PROPN
fnp-3341	27	21	14	14	NUM
fnp-3341	27	22	-	-	SYM
fnp-3341	27	23	16	16	NUM
fnp-3341	27	24	.	.	PUNCT
fnp-3341	28	1	the	the	DET
fnp-3341	28	2	intimate	intimate	ADJ
fnp-3341	28	3	contact	contact	NOUN
fnp-3341	28	4	and	and	CCONJ
fnp-3341	28	5	interaction	interaction	NOUN
fnp-3341	28	6	of	of	ADP
fnp-3341	28	7	the	the	DET
fnp-3341	28	8	bbb	bbb	PROPN
fnp-3341	28	9	complex	complex	NOUN
fnp-3341	28	10	,	,	PUNCT
fnp-3341	28	11	formed	form	VERB
fnp-3341	28	12	by	by	ADP
fnp-3341	28	13	endothelial	endothelial	ADJ
fnp-3341	28	14	cells	cell	NOUN
fnp-3341	28	15	,	,	PUNCT
fnp-3341	28	16	tight	tight	ADJ
fnp-3341	28	17	junctions	junction	NOUN
fnp-3341	28	18	,	,	PUNCT
fnp-3341	28	19	pericytes	pericyte	NOUN
fnp-3341	28	20	and	and	CCONJ
fnp-3341	28	21	astrocyte	astrocyte	NOUN
fnp-3341	28	22	end	end	NOUN
fnp-3341	28	23	-	-	PUNCT
fnp-3341	28	24	feet	foot	NOUN
fnp-3341	28	25	,	,	PUNCT
fnp-3341	28	26	with	with	ADP
fnp-3341	28	27	neurons	neuron	NOUN
fnp-3341	28	28	and	and	CCONJ
fnp-3341	28	29	perivascular	perivascular	ADJ
fnp-3341	28	30	microglia	microglia	ADJ
fnp-3341	28	31	form	form	NOUN
fnp-3341	28	32	a	a	DET
fnp-3341	28	33	dynamic	dynamic	ADJ
fnp-3341	28	34	functional	functional	ADJ
fnp-3341	28	35	unit	unit	NOUN
fnp-3341	28	36	,	,	PUNCT
fnp-3341	28	37	called	call	VERB
fnp-3341	28	38	the	the	DET
fnp-3341	28	39	neurovascular	neurovascular	ADJ
fnp-3341	28	40	unit	unit	NOUN
fnp-3341	28	41	(	(	PUNCT
fnp-3341	28	42	nvu	nvu	NOUN
fnp-3341	28	43	)	)	PUNCT
fnp-3341	28	44	13,14,16	13,14,16	NUM
fnp-3341	28	45	.	.	PUNCT
fnp-3341	29	1	some	some	DET
fnp-3341	29	2	studies	study	NOUN
fnp-3341	29	3	report	report	VERB
fnp-3341	29	4	different	different	ADJ
fnp-3341	29	5	expression	expression	NOUN
fnp-3341	29	6	of	of	ADP
fnp-3341	29	7	tight	tight	ADJ
fnp-3341	29	8	junction	junction	NOUN
fnp-3341	29	9	proteins	protein	NOUN
fnp-3341	29	10	throughout	throughout	ADP
fnp-3341	29	11	the	the	DET
fnp-3341	29	12	brain	brain	NOUN
fnp-3341	29	13	,	,	PUNCT
fnp-3341	29	14	suggestive	suggestive	ADJ
fnp-3341	29	15	of	of	ADP
fnp-3341	29	16	regional	regional	ADJ
fnp-3341	29	17	heterogeneity	heterogeneity	NOUN
fnp-3341	29	18	in	in	ADP
fnp-3341	29	19	bbb	bbb	PROPN
fnp-3341	29	20	permeability	permeability	PROPN
fnp-3341	29	21	17,18	17,18	NUM
fnp-3341	29	22	.	.	PUNCT
fnp-3341	30	1	however	however	ADV
fnp-3341	30	2	,	,	PUNCT
fnp-3341	30	3	little	little	ADJ
fnp-3341	30	4	research	research	NOUN
fnp-3341	30	5	has	have	AUX
fnp-3341	30	6	been	be	AUX
fnp-3341	30	7	done	do	VERB
fnp-3341	30	8	on	on	ADP
fnp-3341	30	9	the	the	DET
fnp-3341	30	10	bbb	bbb	NOUN
fnp-3341	30	11	and	and	CCONJ
fnp-3341	30	12	nvu	nvu	NOUN
fnp-3341	30	13	in	in	ADP
fnp-3341	30	14	the	the	DET
fnp-3341	30	15	brainstem	brainstem	NOUN
fnp-3341	30	16	and	and	CCONJ
fnp-3341	30	17	particularly	particularly	ADV
fnp-3341	30	18	in	in	ADP
fnp-3341	30	19	the	the	DET
fnp-3341	30	20	pons	pon	NOUN
fnp-3341	30	21	.	.	PUNCT
fnp-3341	31	1	yet	yet	ADV
fnp-3341	31	2	,	,	PUNCT
fnp-3341	31	3	better	well	ADJ
fnp-3341	31	4	insight	insight	NOUN
fnp-3341	31	5	into	into	ADP
fnp-3341	31	6	the	the	DET
fnp-3341	31	7	bbb	bbb	NOUN
fnp-3341	31	8	and	and	CCONJ
fnp-3341	31	9	the	the	DET
fnp-3341	31	10	nvu	nvu	NOUN
fnp-3341	31	11	at	at	ADP
fnp-3341	31	12	these	these	DET
fnp-3341	31	13	sites	site	NOUN
fnp-3341	31	14	is	be	AUX
fnp-3341	31	15	needed	need	VERB
fnp-3341	31	16	to	to	PART
fnp-3341	31	17	develop	develop	VERB
fnp-3341	31	18	new	new	ADJ
fnp-3341	31	19	treatment	treatment	NOUN
fnp-3341	31	20	strategies	strategy	NOUN
fnp-3341	31	21	for	for	ADP
fnp-3341	31	22	pediatric	pediatric	ADJ
fnp-3341	31	23	brainstem	brainstem	NOUN
fnp-3341	31	24	tumors	tumor	NOUN
fnp-3341	31	25	.	.	PUNCT
fnp-3341	32	1	this	this	PRON
fnp-3341	32	2	especially	especially	ADV
fnp-3341	32	3	holds	hold	VERB
fnp-3341	32	4	true	true	ADJ
fnp-3341	32	5	for	for	ADP
fnp-3341	32	6	dipg	dipg	NOUN
fnp-3341	32	7	,	,	PUNCT
fnp-3341	32	8	where	where	SCONJ
fnp-3341	32	9	the	the	DET
fnp-3341	32	10	bbb	bbb	PROPN
fnp-3341	32	11	is	be	AUX
fnp-3341	32	12	thought	think	VERB
fnp-3341	32	13	to	to	PART
fnp-3341	32	14	be	be	AUX
fnp-3341	32	15	a	a	DET
fnp-3341	32	16	major	major	ADJ
fnp-3341	32	17	contributor	contributor	NOUN
fnp-3341	32	18	to	to	ADP
fnp-3341	32	19	therapeutic	therapeutic	ADJ
fnp-3341	32	20	inefficacy	inefficacy	NOUN
fnp-3341	32	21	.	.	PUNCT
fnp-3341	33	1	in	in	ADP
fnp-3341	33	2	this	this	DET
fnp-3341	33	3	study	study	NOUN
fnp-3341	33	4	,	,	PUNCT
fnp-3341	33	5	we	we	PRON
fnp-3341	33	6	aim	aim	VERB
fnp-3341	33	7	at	at	ADP
fnp-3341	33	8	determining	determine	VERB
fnp-3341	33	9	and	and	CCONJ
fnp-3341	33	10	comparing	compare	VERB
fnp-3341	33	11	the	the	DET
fnp-3341	33	12	histological	histological	ADJ
fnp-3341	33	13	and	and	CCONJ
fnp-3341	33	14	immunohistochemical	immunohistochemical	ADJ
fnp-3341	33	15	characteristics	characteristic	NOUN
fnp-3341	33	16	of	of	ADP
fnp-3341	33	17	the	the	DET
fnp-3341	33	18	nvu	nvu	NOUN
fnp-3341	33	19	of	of	ADP
fnp-3341	33	20	the	the	DET
fnp-3341	33	21	pons	pon	NOUN
fnp-3341	33	22	in	in	ADP
fnp-3341	33	23	children	child	NOUN
fnp-3341	33	24	with	with	ADP
fnp-3341	33	25	dipg	dipg	NOUN
fnp-3341	33	26	and	and	CCONJ
fnp-3341	33	27	age	age	NOUN
fnp-3341	33	28	-	-	PUNCT
fnp-3341	33	29	matched	match	VERB
fnp-3341	33	30	controls	control	NOUN
fnp-3341	33	31	.	.	PUNCT
fnp-3341	34	1	figure	figure	NOUN
fnp-3341	34	2	1	1	NUM
fnp-3341	34	3	:	:	PUNCT
fnp-3341	34	4	characteristics	characteristic	NOUN
fnp-3341	34	5	of	of	ADP
fnp-3341	34	6	diffuse	diffuse	PROPN
fnp-3341	34	7	intrinsic	intrinsic	ADJ
fnp-3341	34	8	pontine	pontine	ADJ
fnp-3341	34	9	glioma	glioma	NOUN
fnp-3341	34	10	(	(	PUNCT
fnp-3341	34	11	dipg	dipg	PROPN
fnp-3341	34	12	)	)	PUNCT
fnp-3341	34	13	.	.	PUNCT
fnp-3341	35	1	a	a	DET
fnp-3341	35	2	:	:	PUNCT
fnp-3341	35	3	t2	t2	NOUN
fnp-3341	35	4	-	-	PUNCT
fnp-3341	35	5	weighted	weight	VERB
fnp-3341	35	6	mri	mri	NOUN
fnp-3341	35	7	-	-	PUNCT
fnp-3341	35	8	image	image	NOUN
fnp-3341	35	9	of	of	ADP
fnp-3341	35	10	a	a	DET
fnp-3341	35	11	dipg	dipg	NOUN
fnp-3341	35	12	patient	patient	NOUN
fnp-3341	35	13	showing	show	VERB
fnp-3341	35	14	an	an	DET
fnp-3341	35	15	expanded	expand	VERB
fnp-3341	35	16	tumor	tumor	NOUN
fnp-3341	35	17	at	at	ADP
fnp-3341	35	18	the	the	DET
fnp-3341	35	19	basis	basis	NOUN
fnp-3341	35	20	of	of	ADP
fnp-3341	35	21	the	the	DET
fnp-3341	35	22	pons	pon	NOUN
fnp-3341	35	23	.	.	PUNCT
fnp-3341	36	1	the	the	DET
fnp-3341	36	2	arrow	arrow	NOUN
fnp-3341	36	3	indicates	indicate	VERB
fnp-3341	36	4	the	the	DET
fnp-3341	36	5	biopsy	biopsy	NOUN
fnp-3341	36	6	sampling	sample	VERB
fnp-3341	36	7	area	area	NOUN
fnp-3341	36	8	;	;	PUNCT
fnp-3341	36	9	b	b	X
fnp-3341	36	10	:	:	PUNCT
fnp-3341	36	11	gross	gross	ADJ
fnp-3341	36	12	axial	axial	ADJ
fnp-3341	36	13	section	section	NOUN
fnp-3341	36	14	of	of	ADP
fnp-3341	36	15	the	the	DET
fnp-3341	36	16	pons	pon	NOUN
fnp-3341	36	17	and	and	CCONJ
fnp-3341	36	18	cerebellum	cerebellum	NOUN
fnp-3341	36	19	showing	show	VERB
fnp-3341	36	20	the	the	DET
fnp-3341	36	21	presence	presence	NOUN
fnp-3341	36	22	of	of	ADP
fnp-3341	36	23	a	a	DET
fnp-3341	36	24	diffuse	diffuse	NOUN
fnp-3341	36	25	infiltrating	infiltrate	VERB
fnp-3341	36	26	tumor	tumor	NOUN
fnp-3341	36	27	in	in	ADP
fnp-3341	36	28	the	the	DET
fnp-3341	36	29	pons	pon	NOUN
fnp-3341	36	30	,	,	PUNCT
fnp-3341	36	31	reaching	reach	VERB
fnp-3341	36	32	the	the	DET
fnp-3341	36	33	middle	middle	ADJ
fnp-3341	36	34	cerebellar	cerebellar	ADJ
fnp-3341	36	35	peduncles	peduncle	NOUN
fnp-3341	36	36	.	.	PUNCT
fnp-3341	37	1	the	the	DET
fnp-3341	37	2	box	box	PROPN
fnp-3341	37	3	indicates	indicate	VERB
fnp-3341	37	4	the	the	DET
fnp-3341	37	5	sampling	sample	VERB
fnp-3341	37	6	location	location	NOUN
fnp-3341	37	7	of	of	ADP
fnp-3341	37	8	autopsy	autopsy	ADJ
fnp-3341	37	9	tissue	tissue	NOUN
fnp-3341	37	10	at	at	ADP
fnp-3341	37	11	the	the	DET
fnp-3341	37	12	non	non	ADJ
fnp-3341	37	13	-	-	ADJ
fnp-3341	37	14	necrotic	necrotic	ADJ
fnp-3341	37	15	tumor	tumor	NOUN
fnp-3341	37	16	site	site	NOUN
fnp-3341	37	17	;	;	PUNCT
fnp-3341	37	18	c	c	X
fnp-3341	37	19	-	-	PUNCT
fnp-3341	37	20	e	e	NOUN
fnp-3341	37	21	:	:	PUNCT
fnp-3341	37	22	hematoxylin	hematoxylin	NOUN
fnp-3341	37	23	and	and	CCONJ
fnp-3341	37	24	eosin	eosin	PROPN
fnp-3341	37	25	(	(	PUNCT
fnp-3341	37	26	h&e	h&e	PROPN
fnp-3341	37	27	)	)	PUNCT
fnp-3341	37	28	staining	stain	VERB
fnp-3341	37	29	of	of	ADP
fnp-3341	37	30	the	the	DET
fnp-3341	37	31	vital	vital	ADJ
fnp-3341	37	32	tumor	tumor	NOUN
fnp-3341	37	33	bulk	bulk	NOUN
fnp-3341	37	34	showing	show	VERB
fnp-3341	37	35	morphologic	morphologic	ADJ
fnp-3341	37	36	heterogeneity	heterogeneity	NOUN
fnp-3341	37	37	compatible	compatible	ADJ
fnp-3341	37	38	with	with	ADP
fnp-3341	37	39	who	who	PRON
fnp-3341	37	40	grade	grade	NOUN
fnp-3341	37	41	iv	iv	NUM
fnp-3341	37	42	tumors	tumor	NOUN
fnp-3341	37	43	(	(	PUNCT
fnp-3341	37	44	c	c	NOUN
fnp-3341	37	45	and	and	CCONJ
fnp-3341	37	46	d	d	NOUN
fnp-3341	37	47	)	)	PUNCT
fnp-3341	37	48	and	and	CCONJ
fnp-3341	37	49	grade	grade	NOUN
fnp-3341	37	50	i	i	PRON
fnp-3341	37	51	tumors	tumor	NOUN
fnp-3341	37	52	(	(	PUNCT
fnp-3341	37	53	e	e	NOUN
fnp-3341	37	54	)	)	PUNCT
fnp-3341	37	55	;	;	PUNCT
fnp-3341	37	56	f	f	X
fnp-3341	37	57	-	-	PUNCT
fnp-3341	37	58	h	h	NOUN
fnp-3341	37	59	:	:	PUNCT
fnp-3341	37	60	stains	stain	NOUN
fnp-3341	37	61	against	against	ADP
fnp-3341	37	62	intravascular	intravascular	ADJ
fnp-3341	37	63	plasma	plasma	NOUN
fnp-3341	37	64	proteins	protein	NOUN
fnp-3341	37	65	pre	pre	ADJ
fnp-3341	37	66	-	-	ADJ
fnp-3341	37	67	albumin	albumin	ADJ
fnp-3341	37	68	(	(	PUNCT
fnp-3341	37	69	f	f	NOUN
fnp-3341	37	70	)	)	PUNCT
fnp-3341	37	71	,	,	PUNCT
fnp-3341	37	72	fibrinogen	fibrinogen	X
fnp-3341	37	73	(	(	PUNCT
fnp-3341	37	74	g	g	NOUN
fnp-3341	37	75	)	)	PUNCT
fnp-3341	37	76	and	and	CCONJ
fnp-3341	37	77	igg	igg	PROPN
fnp-3341	37	78	(	(	PUNCT
fnp-3341	37	79	h	h	NOUN
fnp-3341	37	80	)	)	PUNCT
fnp-3341	37	81	showing	show	VERB
fnp-3341	37	82	extravasation	extravasation	NOUN
fnp-3341	37	83	of	of	ADP
fnp-3341	37	84	these	these	DET
fnp-3341	37	85	protein	protein	NOUN
fnp-3341	37	86	into	into	ADP
fnp-3341	37	87	the	the	DET
fnp-3341	37	88	dipg	dipg	NOUN
fnp-3341	37	89	tumor	tumor	NOUN
fnp-3341	37	90	parenchyma	parenchyma	NOUN
fnp-3341	37	91	;	;	PUNCT
fnp-3341	37	92	i	i	PROPN
fnp-3341	37	93	-	-	PUNCT
fnp-3341	37	94	k	k	NOUN
fnp-3341	37	95	:	:	PUNCT
fnp-3341	37	96	hypoxia	hypoxia	NOUN
fnp-3341	37	97	inducible	inducible	ADJ
fnp-3341	37	98	factor-1α	factor-1α	PROPN
fnp-3341	37	99	(	(	PUNCT
fnp-3341	37	100	hif-1α	hif-1α	NOUN
fnp-3341	37	101	)	)	PUNCT
fnp-3341	37	102	staining	stain	VERB
fnp-3341	37	103	demonstrating	demonstrate	VERB
fnp-3341	37	104	a	a	DET
fnp-3341	37	105	high	high	ADJ
fnp-3341	37	106	expression	expression	NOUN
fnp-3341	37	107	of	of	ADP
fnp-3341	37	108	hif-1α	hif-1α	NOUN
fnp-3341	37	109	.	.	PUNCT
fnp-3341	38	1	(	(	PUNCT
fnp-3341	38	2	scale	scale	NOUN
fnp-3341	38	3	bar	bar	NOUN
fnp-3341	38	4	:	:	PUNCT
fnp-3341	38	5	5	5	NUM
fnp-3341	38	6	µm	µm	NOUN
fnp-3341	38	7	)	)	PUNCT
fnp-3341	38	8	patients	patient	NOUN
fnp-3341	38	9	and	and	CCONJ
fnp-3341	38	10	methods	method	NOUN
fnp-3341	38	11	patients	patient	NOUN
fnp-3341	38	12	and	and	CCONJ
fnp-3341	38	13	samples	sample	VERB
fnp-3341	38	14	dipg	dipg	NOUN
fnp-3341	38	15	pre	pre	ADJ
fnp-3341	38	16	-	-	ADJ
fnp-3341	38	17	treatment	treatment	ADJ
fnp-3341	38	18	biopsy	biopsy	NOUN
fnp-3341	38	19	samples	sample	NOUN
fnp-3341	38	20	(	(	PUNCT
fnp-3341	38	21	n	n	NOUN
fnp-3341	38	22	=	=	SYM
fnp-3341	38	23	4	4	X
fnp-3341	38	24	)	)	PUNCT
fnp-3341	38	25	were	be	AUX
fnp-3341	38	26	obtained	obtain	VERB
fnp-3341	38	27	from	from	ADP
fnp-3341	38	28	the	the	DET
fnp-3341	38	29	biobank	biobank	NOUN
fnp-3341	38	30	of	of	ADP
fnp-3341	38	31	the	the	DET
fnp-3341	38	32	princess	princess	ADJ
fnp-3341	38	33	máxima	máxima	PROPN
fnp-3341	38	34	center	center	PROPN
fnp-3341	38	35	for	for	ADP
fnp-3341	38	36	pediatric	pediatric	ADJ
fnp-3341	38	37	oncology	oncology	NOUN
fnp-3341	38	38	,	,	PUNCT
fnp-3341	38	39	utrecht	utrecht	PROPN
fnp-3341	38	40	,	,	PUNCT
fnp-3341	38	41	the	the	DET
fnp-3341	38	42	netherlands	netherlands	PROPN
fnp-3341	38	43	,	,	PUNCT
fnp-3341	38	44	and	and	CCONJ
fnp-3341	38	45	processed	process	VERB
fnp-3341	38	46	as	as	ADP
fnp-3341	38	47	formalin	formalin	NOUN
fnp-3341	38	48	-	-	PUNCT
fnp-3341	38	49	fixed	fix	VERB
fnp-3341	38	50	paraffin	paraffin	NOUN
fnp-3341	38	51	-	-	PUNCT
fnp-3341	38	52	embedded	embed	VERB
fnp-3341	38	53	tissue	tissue	NOUN
fnp-3341	38	54	.	.	PUNCT
fnp-3341	39	1	end	end	NOUN
fnp-3341	39	2	-	-	PUNCT
fnp-3341	39	3	stage	stage	NOUN
fnp-3341	39	4	disease	disease	NOUN
fnp-3341	39	5	dipg	dipg	NOUN
fnp-3341	39	6	autopsy	autopsy	ADJ
fnp-3341	39	7	samples	sample	NOUN
fnp-3341	39	8	(	(	PUNCT
fnp-3341	39	9	n	n	NOUN
fnp-3341	39	10	=	=	SYM
fnp-3341	39	11	6	6	NUM
fnp-3341	39	12	)	)	PUNCT
fnp-3341	39	13	were	be	AUX
fnp-3341	39	14	obtained	obtain	VERB
fnp-3341	39	15	from	from	ADP
fnp-3341	39	16	the	the	DET
fnp-3341	39	17	‘	'	PUNCT
fnp-3341	39	18	vumc	vumc	ADJ
fnp-3341	39	19	brain	brain	NOUN
fnp-3341	39	20	autopsy	autopsy	ADJ
fnp-3341	39	21	in	in	ADP
fnp-3341	39	22	children	child	NOUN
fnp-3341	39	23	with	with	ADP
fnp-3341	39	24	dipg	dipg	NOUN
fnp-3341	39	25	’	'	PUNCT
fnp-3341	39	26	study	study	NOUN
fnp-3341	39	27	19	19	NUM
fnp-3341	39	28	.	.	PUNCT
fnp-3341	40	1	this	this	DET
fnp-3341	40	2	study	study	NOUN
fnp-3341	40	3	was	be	AUX
fnp-3341	40	4	approved	approve	VERB
fnp-3341	40	5	by	by	ADP
fnp-3341	40	6	the	the	DET
fnp-3341	40	7	institutional	institutional	ADJ
fnp-3341	40	8	review	review	PROPN
fnp-3341	40	9	board	board	NOUN
fnp-3341	40	10	of	of	ADP
fnp-3341	40	11	amsterdam	amsterdam	PROPN
fnp-3341	40	12	umc	umc	PROPN
fnp-3341	40	13	,	,	PUNCT
fnp-3341	40	14	location	location	NOUN
fnp-3341	40	15	vumc	vumc	NOUN
fnp-3341	40	16	(	(	PUNCT
fnp-3341	40	17	metc	metc	ADJ
fnp-3341	40	18	vumc	vumc	NOUN
fnp-3341	40	19	,	,	PUNCT
fnp-3341	40	20	study	study	NOUN
fnp-3341	40	21	number	number	NOUN
fnp-3341	40	22	:	:	PUNCT
fnp-3341	40	23	vumc2009/237	vumc2009/237	PROPN
fnp-3341	40	24	)	)	PUNCT
fnp-3341	40	25	and	and	CCONJ
fnp-3341	40	26	the	the	DET
fnp-3341	40	27	scientific	scientific	ADJ
fnp-3341	40	28	committee	committee	NOUN
fnp-3341	40	29	of	of	ADP
fnp-3341	40	30	the	the	DET
fnp-3341	40	31	dutch	dutch	ADJ
fnp-3341	40	32	childhood	childhood	PROPN
fnp-3341	40	33	oncology	oncology	NOUN
fnp-3341	40	34	group	group	NOUN
fnp-3341	40	35	(	(	PUNCT
fnp-3341	40	36	dcog	dcog	PROPN
fnp-3341	40	37	)	)	PUNCT
fnp-3341	40	38	.	.	PUNCT
fnp-3341	41	1	in	in	ADP
fnp-3341	41	2	this	this	DET
fnp-3341	41	3	study	study	NOUN
fnp-3341	41	4	,	,	PUNCT
fnp-3341	41	5	brain	brain	NOUN
fnp-3341	41	6	tissue	tissue	NOUN
fnp-3341	41	7	was	be	AUX
fnp-3341	41	8	obtained	obtain	VERB
fnp-3341	41	9	within	within	ADP
fnp-3341	41	10	a	a	DET
fnp-3341	41	11	post	post	ADJ
fnp-3341	41	12	-	-	ADJ
fnp-3341	41	13	mortem	mortem	ADJ
fnp-3341	41	14	interval	interval	NOUN
fnp-3341	41	15	of	of	ADP
fnp-3341	41	16	less	less	ADJ
fnp-3341	41	17	than	than	ADP
fnp-3341	41	18	six	six	NUM
fnp-3341	41	19	hours	hour	NOUN
fnp-3341	41	20	for	for	ADP
fnp-3341	41	21	dutch	dutch	ADJ
fnp-3341	41	22	patients	patient	NOUN
fnp-3341	41	23	and	and	CCONJ
fnp-3341	41	24	less	less	ADJ
fnp-3341	41	25	than	than	ADP
fnp-3341	41	26	nine	nine	NUM
fnp-3341	41	27	hours	hour	NOUN
fnp-3341	41	28	for	for	ADP
fnp-3341	41	29	patients	patient	NOUN
fnp-3341	41	30	from	from	ADP
fnp-3341	41	31	abroad	abroad	ADV
fnp-3341	41	32	,	,	PUNCT
fnp-3341	41	33	and	and	CCONJ
fnp-3341	41	34	was	be	AUX
fnp-3341	41	35	processed	process	VERB
fnp-3341	41	36	as	as	ADP
fnp-3341	41	37	formalin	formalin	NOUN
fnp-3341	41	38	-	-	PUNCT
fnp-3341	41	39	fixed	fix	VERB
fnp-3341	41	40	paraffin	paraffin	NOUN
fnp-3341	41	41	-	-	PUNCT
fnp-3341	41	42	embedded	embed	VERB
fnp-3341	41	43	tissue	tissue	NOUN
fnp-3341	41	44	or	or	CCONJ
fnp-3341	41	45	snap	snap	VERB
fnp-3341	41	46	frozen	freeze	VERB
fnp-3341	41	47	.	.	PUNCT
fnp-3341	42	1	biopsy	biopsy	NOUN
fnp-3341	42	2	samples	sample	NOUN
fnp-3341	42	3	were	be	AUX
fnp-3341	42	4	mri	mri	NOUN
fnp-3341	42	5	-	-	PUNCT
fnp-3341	42	6	guided	guide	VERB
fnp-3341	42	7	and	and	CCONJ
fnp-3341	42	8	taken	take	VERB
fnp-3341	42	9	from	from	ADP
fnp-3341	42	10	the	the	DET
fnp-3341	42	11	tumor	tumor	NOUN
fnp-3341	42	12	area	area	NOUN
fnp-3341	42	13	displaying	display	VERB
fnp-3341	42	14	the	the	DET
fnp-3341	42	15	highest	high	ADJ
fnp-3341	42	16	hyper	hyper	NOUN
fnp-3341	42	17	-	-	NOUN
fnp-3341	42	18	intensity	intensity	NOUN
fnp-3341	42	19	on	on	ADP
fnp-3341	42	20	t2	t2	NOUN
fnp-3341	42	21	-	-	PUNCT
fnp-3341	42	22	weighted	weight	VERB
fnp-3341	42	23	image	image	NOUN
fnp-3341	42	24	(	(	PUNCT
fnp-3341	42	25	figure	figure	NOUN
fnp-3341	42	26	1a	1a	NOUN
fnp-3341	42	27	)	)	PUNCT
fnp-3341	42	28	.	.	PUNCT
fnp-3341	43	1	autopsy	autopsy	ADJ
fnp-3341	43	2	samples	sample	NOUN
fnp-3341	43	3	were	be	AUX
fnp-3341	43	4	obtained	obtain	VERB
fnp-3341	43	5	from	from	ADP
fnp-3341	43	6	the	the	DET
fnp-3341	43	7	non	non	ADJ
fnp-3341	43	8	-	-	ADJ
fnp-3341	43	9	necrotic	necrotic	ADJ
fnp-3341	43	10	tumor	tumor	NOUN
fnp-3341	43	11	core	core	NOUN
fnp-3341	43	12	in	in	ADP
fnp-3341	43	13	the	the	DET
fnp-3341	43	14	pons	pon	NOUN
fnp-3341	43	15	(	(	PUNCT
fnp-3341	43	16	figure	figure	NOUN
fnp-3341	43	17	1b	1b	NUM
fnp-3341	43	18	)	)	PUNCT
fnp-3341	43	19	.	.	PUNCT
fnp-3341	44	1	age	age	NOUN
fnp-3341	44	2	-	-	PUNCT
fnp-3341	44	3	matched	match	VERB
fnp-3341	44	4	,	,	PUNCT
fnp-3341	44	5	healthy	healthy	ADJ
fnp-3341	44	6	pontine	pontine	ADJ
fnp-3341	44	7	tissue	tissue	NOUN
fnp-3341	44	8	samples	sample	NOUN
fnp-3341	44	9	(	(	PUNCT
fnp-3341	44	10	n	n	NOUN
fnp-3341	44	11	=	=	NUM
fnp-3341	44	12	20	20	NUM
fnp-3341	44	13	)	)	PUNCT
fnp-3341	44	14	where	where	SCONJ
fnp-3341	44	15	obtained	obtain	VERB
fnp-3341	44	16	from	from	ADP
fnp-3341	44	17	the	the	DET
fnp-3341	44	18	nih	nih	PROPN
fnp-3341	44	19	neurobiobank	neurobiobank	PROPN
fnp-3341	44	20	,	,	PUNCT
fnp-3341	44	21	maryland	maryland	PROPN
fnp-3341	44	22	,	,	PUNCT
fnp-3341	44	23	united	united	PROPN
fnp-3341	44	24	states	states	PROPN
fnp-3341	44	25	.	.	PUNCT
fnp-3341	45	1	samples	sample	NOUN
fnp-3341	45	2	were	be	AUX
fnp-3341	45	3	selected	select	VERB
fnp-3341	45	4	based	base	VERB
fnp-3341	45	5	on	on	ADP
fnp-3341	45	6	(	(	PUNCT
fnp-3341	45	7	i	i	NOUN
fnp-3341	45	8	)	)	PUNCT
fnp-3341	45	9	brain	brain	NOUN
fnp-3341	45	10	region	region	NOUN
fnp-3341	45	11	(	(	PUNCT
fnp-3341	45	12	pons	pon	NOUN
fnp-3341	45	13	)	)	PUNCT
fnp-3341	45	14	,	,	PUNCT
fnp-3341	45	15	(	(	PUNCT
fnp-3341	45	16	ii	ii	NOUN
fnp-3341	45	17	)	)	PUNCT
fnp-3341	45	18	clinical	clinical	ADJ
fnp-3341	45	19	brain	brain	NOUN
fnp-3341	45	20	diagnosis	diagnosis	NOUN
fnp-3341	45	21	(	(	PUNCT
fnp-3341	45	22	unaffected	unaffected	ADJ
fnp-3341	45	23	control	control	NOUN
fnp-3341	45	24	/	/	SYM
fnp-3341	45	25	sudden	sudden	ADJ
fnp-3341	45	26	deaths	death	NOUN
fnp-3341	45	27	)	)	PUNCT
fnp-3341	45	28	,	,	PUNCT
fnp-3341	45	29	(	(	PUNCT
fnp-3341	45	30	iii	iii	X
fnp-3341	45	31	)	)	PUNCT
fnp-3341	45	32	post	post	ADJ
fnp-3341	45	33	-	-	ADJ
fnp-3341	45	34	mortem	mortem	ADJ
fnp-3341	45	35	interval	interval	NOUN
fnp-3341	45	36	(	(	PUNCT
fnp-3341	45	37	<	<	X
fnp-3341	45	38	17	17	NUM
fnp-3341	45	39	hours	hour	NOUN
fnp-3341	45	40	)	)	PUNCT
fnp-3341	45	41	,	,	PUNCT
fnp-3341	45	42	and	and	CCONJ
fnp-3341	45	43	(	(	PUNCT
fnp-3341	45	44	iv	iv	X
fnp-3341	45	45	)	)	PUNCT
fnp-3341	45	46	presence	presence	NOUN
fnp-3341	45	47	of	of	ADP
fnp-3341	45	48	formalin	formalin	NOUN
fnp-3341	45	49	-	-	PUNCT
fnp-3341	45	50	fixed	fix	VERB
fnp-3341	45	51	tissue	tissue	NOUN
fnp-3341	45	52	and	and	CCONJ
fnp-3341	45	53	frozen	frozen	ADJ
fnp-3341	45	54	tissue	tissue	NOUN
fnp-3341	45	55	.	.	PUNCT
fnp-3341	46	1	table	table	NOUN
fnp-3341	46	2	1	1	NUM
fnp-3341	46	3	shows	show	VERB
fnp-3341	46	4	patient	patient	ADJ
fnp-3341	46	5	and	and	CCONJ
fnp-3341	46	6	treatment	treatment	NOUN
fnp-3341	46	7	characteristics	characteristic	NOUN
fnp-3341	46	8	of	of	ADP
fnp-3341	46	9	the	the	DET
fnp-3341	46	10	dipg	dipg	NOUN
fnp-3341	46	11	patients	patient	NOUN
fnp-3341	46	12	.	.	PUNCT
fnp-3341	47	1	median	median	ADJ
fnp-3341	47	2	age	age	NOUN
fnp-3341	47	3	at	at	ADP
fnp-3341	47	4	diagnosis	diagnosis	NOUN
fnp-3341	47	5	was	be	AUX
fnp-3341	47	6	7.7	7.7	NUM
fnp-3341	47	7	years	year	NOUN
fnp-3341	47	8	(	(	PUNCT
fnp-3341	47	9	range	range	NOUN
fnp-3341	47	10	1.3	1.3	NUM
fnp-3341	47	11	-	-	SYM
fnp-3341	47	12	17.0	17.0	NUM
fnp-3341	47	13	years	year	NOUN
fnp-3341	47	14	)	)	PUNCT
fnp-3341	47	15	.	.	PUNCT
fnp-3341	48	1	all	all	DET
fnp-3341	48	2	patients	patient	NOUN
fnp-3341	48	3	had	have	VERB
fnp-3341	48	4	a	a	DET
fnp-3341	48	5	h3k27	h3k27	PROPN
fnp-3341	48	6	m	m	NUM
fnp-3341	48	7	mutated	mutate	VERB
fnp-3341	48	8	dipg	dipg	NOUN
fnp-3341	48	9	.	.	PUNCT
fnp-3341	49	1	all	all	DET
fnp-3341	49	2	autopsy	autopsy	ADJ
fnp-3341	49	3	patients	patient	NOUN
fnp-3341	49	4	,	,	PUNCT
fnp-3341	49	5	except	except	SCONJ
fnp-3341	49	6	for	for	ADP
fnp-3341	49	7	the	the	DET
fnp-3341	49	8	youngest	young	ADJ
fnp-3341	49	9	,	,	PUNCT
fnp-3341	49	10	received	receive	VERB
fnp-3341	49	11	radiotherapy	radiotherapy	NOUN
fnp-3341	49	12	at	at	ADP
fnp-3341	49	13	diagnosis	diagnosis	NOUN
fnp-3341	49	14	.	.	PUNCT
fnp-3341	50	1	of	of	ADP
fnp-3341	50	2	these	these	PRON
fnp-3341	50	3	,	,	PUNCT
fnp-3341	50	4	at	at	ADP
fnp-3341	50	5	disease	disease	NOUN
fnp-3341	50	6	progression	progression	NOUN
fnp-3341	50	7	,	,	PUNCT
fnp-3341	50	8	three	three	NUM
fnp-3341	50	9	out	out	ADP
fnp-3341	50	10	of	of	ADP
fnp-3341	50	11	six	six	NUM
fnp-3341	50	12	received	receive	VERB
fnp-3341	50	13	different	different	ADJ
fnp-3341	50	14	chemotherapy	chemotherapy	NOUN
fnp-3341	50	15	regimens	regimen	NOUN
fnp-3341	50	16	and	and	CCONJ
fnp-3341	50	17	two	two	NUM
fnp-3341	50	18	patients	patient	NOUN
fnp-3341	50	19	did	do	AUX
fnp-3341	50	20	not	not	PART
fnp-3341	50	21	proceed	proceed	VERB
fnp-3341	50	22	to	to	ADP
fnp-3341	50	23	further	further	ADJ
fnp-3341	50	24	treatment	treatment	NOUN
fnp-3341	50	25	.	.	PUNCT
fnp-3341	51	1	median	median	ADJ
fnp-3341	51	2	overall	overall	ADJ
fnp-3341	51	3	survival	survival	NOUN
fnp-3341	51	4	of	of	ADP
fnp-3341	51	5	patients	patient	NOUN
fnp-3341	51	6	that	that	PRON
fnp-3341	51	7	were	be	AUX
fnp-3341	51	8	autopsied	autopsie	VERB
fnp-3341	51	9	was	be	AUX
fnp-3341	51	10	19.5	19.5	NUM
fnp-3341	51	11	months	month	NOUN
fnp-3341	51	12	(	(	PUNCT
fnp-3341	51	13	range	range	NOUN
fnp-3341	51	14	5.5	5.5	NUM
fnp-3341	51	15	-	-	SYM
fnp-3341	51	16	24.0	24.0	NUM
fnp-3341	51	17	months	month	NOUN
fnp-3341	51	18	)	)	PUNCT
fnp-3341	51	19	.	.	PUNCT
fnp-3341	52	1	supplementary	supplementary	ADJ
fnp-3341	52	2	table	table	NOUN
fnp-3341	52	3	1	1	NUM
fnp-3341	52	4	shows	show	VERB
fnp-3341	52	5	the	the	DET
fnp-3341	52	6	characteristics	characteristic	NOUN
fnp-3341	52	7	of	of	ADP
fnp-3341	52	8	the	the	DET
fnp-3341	52	9	control	control	NOUN
fnp-3341	52	10	group	group	NOUN
fnp-3341	52	11	.	.	PUNCT
fnp-3341	53	1	median	median	ADJ
fnp-3341	53	2	age	age	NOUN
fnp-3341	53	3	was	be	AUX
fnp-3341	53	4	7.0	7.0	NUM
fnp-3341	53	5	years	year	NOUN
fnp-3341	53	6	(	(	PUNCT
fnp-3341	53	7	range	range	NOUN
fnp-3341	53	8	1.0	1.0	NUM
fnp-3341	53	9	-	-	SYM
fnp-3341	53	10	19.0	19.0	NUM
fnp-3341	53	11	years	year	NOUN
fnp-3341	53	12	)	)	PUNCT
fnp-3341	53	13	.	.	PUNCT
fnp-3341	54	1	all	all	DET
fnp-3341	54	2	controls	control	NOUN
fnp-3341	54	3	were	be	AUX
fnp-3341	54	4	healthy	healthy	ADJ
fnp-3341	54	5	and	and	CCONJ
fnp-3341	54	6	had	have	VERB
fnp-3341	54	7	an	an	DET
fnp-3341	54	8	accidental	accidental	ADJ
fnp-3341	54	9	death	death	NOUN
fnp-3341	54	10	.	.	PUNCT
fnp-3341	55	1	immunohistochemistry	immunohistochemistry	PROPN
fnp-3341	55	2	air	air	NOUN
fnp-3341	55	3	-	-	PUNCT
fnp-3341	55	4	dried	dry	VERB
fnp-3341	55	5	five	five	NUM
fnp-3341	55	6	-	-	PUNCT
fnp-3341	55	7	μm	μm	NUM
fnp-3341	55	8	-	-	PUNCT
fnp-3341	55	9	thick	thick	ADJ
fnp-3341	55	10	cryosections	cryosection	NOUN
fnp-3341	55	11	were	be	AUX
fnp-3341	55	12	fixed	fix	VERB
fnp-3341	55	13	in	in	ADP
fnp-3341	55	14	2	2	NUM
fnp-3341	55	15	%	%	NOUN
fnp-3341	55	16	formaldehyde	formaldehyde	NOUN
fnp-3341	55	17	for	for	ADP
fnp-3341	55	18	10	10	NUM
fnp-3341	55	19	min	min	NOUN
fnp-3341	55	20	at	at	ADP
fnp-3341	55	21	room	room	NOUN
fnp-3341	55	22	temperature	temperature	NOUN
fnp-3341	55	23	(	(	PUNCT
fnp-3341	55	24	rt	rt	PROPN
fnp-3341	55	25	)	)	PUNCT
fnp-3341	55	26	.	.	PUNCT
fnp-3341	56	1	aldehyde	aldehyde	NOUN
fnp-3341	56	2	groups	group	NOUN
fnp-3341	56	3	were	be	AUX
fnp-3341	56	4	blocked	block	VERB
fnp-3341	56	5	in	in	ADP
fnp-3341	56	6	0.1	0.1	NUM
fnp-3341	56	7	g	g	NOUN
fnp-3341	56	8	glycine	glycine	NOUN
fnp-3341	56	9	in	in	ADP
fnp-3341	56	10	100	100	NUM
fnp-3341	56	11	ml	ml	ADP
fnp-3341	56	12	distilled	distil	VERB
fnp-3341	56	13	water	water	NOUN
fnp-3341	56	14	for	for	ADP
fnp-3341	56	15	10	10	NUM
fnp-3341	56	16	min	min	NOUN
fnp-3341	56	17	at	at	ADP
fnp-3341	56	18	rt	rt	PROPN
fnp-3341	56	19	.	.	PUNCT
fnp-3341	56	20	sections	section	NOUN
fnp-3341	56	21	were	be	AUX
fnp-3341	56	22	incubated	incubate	VERB
fnp-3341	56	23	overnight	overnight	ADV
fnp-3341	56	24	at	at	ADP
fnp-3341	56	25	rt	rt	PROPN
fnp-3341	56	26	with	with	ADP
fnp-3341	56	27	a	a	DET
fnp-3341	56	28	primary	primary	ADJ
fnp-3341	56	29	antibody	antibody	NOUN
fnp-3341	56	30	:	:	PUNCT
fnp-3341	56	31	(	(	PUNCT
fnp-3341	56	32	i	i	NOUN
fnp-3341	56	33	)	)	PUNCT
fnp-3341	56	34	tight	tight	ADJ
fnp-3341	56	35	junction	junction	NOUN
fnp-3341	56	36	protein	protein	NOUN
fnp-3341	56	37	claudin-5	claudin-5	X
fnp-3341	56	38	(	(	PUNCT
fnp-3341	56	39	1:50	1:50	NUM
fnp-3341	56	40	,	,	PUNCT
fnp-3341	56	41	invitrogen	invitrogen	PROPN
fnp-3341	56	42	,	,	PUNCT
fnp-3341	56	43	carlsbad	carlsbad	PROPN
fnp-3341	56	44	,	,	PUNCT
fnp-3341	56	45	ca	ca	PROPN
fnp-3341	56	46	,	,	PUNCT
fnp-3341	56	47	usa	usa	PROPN
fnp-3341	56	48	)	)	PUNCT
fnp-3341	56	49	;	;	PUNCT
fnp-3341	56	50	(	(	PUNCT
fnp-3341	56	51	ii	ii	NOUN
fnp-3341	56	52	)	)	PUNCT
fnp-3341	56	53	tight	tight	ADJ
fnp-3341	56	54	junction	junction	NOUN
fnp-3341	56	55	protein	protein	NOUN
fnp-3341	56	56	zo-1	zo-1	PUNCT
fnp-3341	56	57	(	(	PUNCT
fnp-3341	56	58	1:50	1:50	NUM
fnp-3341	56	59	,	,	PUNCT
fnp-3341	56	60	invitrogen	invitrogen	PROPN
fnp-3341	56	61	,	,	PUNCT
fnp-3341	56	62	carlsbad	carlsbad	PROPN
fnp-3341	56	63	,	,	PUNCT
fnp-3341	56	64	ca	ca	PROPN
fnp-3341	56	65	,	,	PUNCT
fnp-3341	56	66	usa	usa	PROPN
fnp-3341	56	67	)	)	PUNCT
fnp-3341	56	68	;	;	PUNCT
fnp-3341	56	69	(	(	PUNCT
fnp-3341	56	70	iii	iii	X
fnp-3341	56	71	)	)	PUNCT
fnp-3341	56	72	basement	basement	NOUN
fnp-3341	56	73	membrane	membrane	NOUN
fnp-3341	56	74	component	component	NOUN
fnp-3341	56	75	laminin	laminin	NOUN
fnp-3341	56	76	(	(	PUNCT
fnp-3341	56	77	1:500	1:500	NUM
fnp-3341	56	78	,	,	PUNCT
fnp-3341	56	79	novus	novus	NOUN
fnp-3341	56	80	biologicals	biological	NOUN
fnp-3341	56	81	,	,	PUNCT
fnp-3341	56	82	abingdon	abingdon	PROPN
fnp-3341	56	83	uk	uk	PROPN
fnp-3341	56	84	)	)	PUNCT
fnp-3341	56	85	;	;	PUNCT
fnp-3341	56	86	or	or	CCONJ
fnp-3341	56	87	(	(	PUNCT
fnp-3341	56	88	iv	iv	X
fnp-3341	56	89	)	)	PUNCT
fnp-3341	56	90	pericyte	pericyte	NOUN
fnp-3341	57	1	marker	marker	NOUN
fnp-3341	57	2	pdgfr	pdgfr	NOUN
fnp-3341	57	3	-	-	PUNCT
fnp-3341	57	4	β	β	NOUN
fnp-3341	57	5	(	(	PUNCT
fnp-3341	57	6	1:500	1:500	NUM
fnp-3341	57	7	,	,	PUNCT
fnp-3341	57	8	abcam	abcam	NOUN
fnp-3341	57	9	,	,	PUNCT
fnp-3341	57	10	cambridge	cambridge	PROPN
fnp-3341	57	11	,	,	PUNCT
fnp-3341	57	12	uk	uk	PROPN
fnp-3341	57	13	)	)	PUNCT
fnp-3341	57	14	.	.	PUNCT
fnp-3341	58	1	the	the	DET
fnp-3341	58	2	sections	section	NOUN
fnp-3341	58	3	were	be	AUX
fnp-3341	58	4	co	co	VERB
fnp-3341	58	5	-	-	VERB
fnp-3341	58	6	stained	stained	ADJ
fnp-3341	58	7	with	with	ADP
fnp-3341	58	8	glial	glial	ADJ
fnp-3341	58	9	fibrillary	fibrillary	ADJ
fnp-3341	58	10	acidic	acidic	ADJ
fnp-3341	58	11	protein	protein	NOUN
fnp-3341	58	12	(	(	PUNCT
fnp-3341	58	13	gfap	gfap	ADJ
fnp-3341	58	14	;	;	PUNCT
fnp-3341	58	15	1:1000	1:1000	NUM
fnp-3341	58	16	,	,	PUNCT
fnp-3341	58	17	merck	merck	PROPN
fnp-3341	58	18	,	,	PUNCT
fnp-3341	58	19	darmstadt	darmstadt	PROPN
fnp-3341	58	20	,	,	PUNCT
fnp-3341	58	21	germany	germany	PROPN
fnp-3341	58	22	)	)	PUNCT
fnp-3341	58	23	.	.	PUNCT
fnp-3341	59	1	the	the	DET
fnp-3341	59	2	following	following	ADJ
fnp-3341	59	3	day	day	NOUN
fnp-3341	59	4	,	,	PUNCT
fnp-3341	59	5	the	the	DET
fnp-3341	59	6	sections	section	NOUN
fnp-3341	59	7	were	be	AUX
fnp-3341	59	8	incubated	incubate	VERB
fnp-3341	59	9	with	with	ADP
fnp-3341	59	10	alexa	alexa	ADJ
fnp-3341	59	11	fluor	fluor	NOUN
fnp-3341	59	12	®	®	NOUN
fnp-3341	59	13	-labelled	-labelled	ADJ
fnp-3341	59	14	secondary	secondary	ADJ
fnp-3341	59	15	antibodies	antibody	NOUN
fnp-3341	59	16	,	,	PUNCT
fnp-3341	59	17	background	background	NOUN
fnp-3341	59	18	was	be	AUX
fnp-3341	59	19	quenched	quench	VERB
fnp-3341	59	20	with	with	ADP
fnp-3341	59	21	0.1	0.1	NUM
fnp-3341	59	22	%	%	NOUN
fnp-3341	59	23	sudan	sudan	PROPN
fnp-3341	59	24	black	black	PROPN
fnp-3341	59	25	b	b	PROPN
fnp-3341	59	26	,	,	PUNCT
fnp-3341	59	27	and	and	CCONJ
fnp-3341	59	28	sections	section	NOUN
fnp-3341	59	29	were	be	AUX
fnp-3341	59	30	mounted	mount	VERB
fnp-3341	59	31	in	in	ADP
fnp-3341	59	32	mounting	mount	VERB
fnp-3341	59	33	medium	medium	NOUN
fnp-3341	59	34	(	(	PUNCT
fnp-3341	59	35	vectashield	vectashield	NOUN
fnp-3341	59	36	with	with	ADP
fnp-3341	59	37	4',6	4',6	NUM
fnp-3341	59	38	-	-	PUNCT
fnp-3341	59	39	diamidino-2	diamidino-2	NOUN
fnp-3341	59	40	-	-	PUNCT
fnp-3341	59	41	fenylindool	fenylindool	NOUN
fnp-3341	59	42	(	(	PUNCT
fnp-3341	59	43	dapi	dapi	ADJ
fnp-3341	59	44	)	)	PUNCT
fnp-3341	59	45	;	;	PUNCT
fnp-3341	59	46	vector	vector	NOUN
fnp-3341	59	47	laboratories	laboratories	PROPN
fnp-3341	59	48	inc	inc	PROPN
fnp-3341	59	49	.	.	PROPN
fnp-3341	59	50	,	,	PUNCT
fnp-3341	59	51	burlingame	burlingame	PROPN
fnp-3341	59	52	,	,	PUNCT
fnp-3341	59	53	ca	ca	PROPN
fnp-3341	59	54	,	,	PUNCT
fnp-3341	59	55	usa	usa	PROPN
fnp-3341	59	56	)	)	PUNCT
fnp-3341	59	57	.	.	PUNCT
fnp-3341	60	1	five	five	NUM
fnp-3341	60	2	-	-	PUNCT
fnp-3341	60	3	μm	μm	NUM
fnp-3341	60	4	-	-	PUNCT
fnp-3341	60	5	thick	thick	ADJ
fnp-3341	60	6	formalin‐fixed	formalin‐fixe	VERB
fnp-3341	60	7	paraffin	paraffin	NOUN
fnp-3341	60	8	-	-	PUNCT
fnp-3341	60	9	embedded	embed	VERB
fnp-3341	60	10	tissue	tissue	NOUN
fnp-3341	60	11	sections	section	NOUN
fnp-3341	60	12	were	be	AUX
fnp-3341	60	13	routinely	routinely	ADV
fnp-3341	60	14	stained	stain	VERB
fnp-3341	60	15	with	with	ADP
fnp-3341	60	16	hematoxylin	hematoxylin	PROPN
fnp-3341	60	17	&	&	CCONJ
fnp-3341	60	18	eosin	eosin	PROPN
fnp-3341	60	19	(	(	PUNCT
fnp-3341	60	20	h&e	h&e	PROPN
fnp-3341	60	21	)	)	PUNCT
fnp-3341	60	22	.	.	PUNCT
fnp-3341	61	1	a	a	DET
fnp-3341	61	2	gross	gross	ADJ
fnp-3341	61	3	axial	axial	ADJ
fnp-3341	61	4	section	section	NOUN
fnp-3341	61	5	through	through	ADP
fnp-3341	61	6	the	the	DET
fnp-3341	61	7	pons	pon	NOUN
fnp-3341	61	8	and	and	CCONJ
fnp-3341	61	9	cerebellum	cerebellum	NOUN
fnp-3341	61	10	was	be	AUX
fnp-3341	61	11	stained	stain	VERB
fnp-3341	61	12	with	with	ADP
fnp-3341	61	13	luxol	luxol	NOUN
fnp-3341	61	14	fast	fast	ADJ
fnp-3341	61	15	blue	blue	ADJ
fnp-3341	61	16	-	-	PUNCT
fnp-3341	61	17	periodic	periodic	ADJ
fnp-3341	61	18	acid	acid	NOUN
fnp-3341	61	19	-	-	PUNCT
fnp-3341	61	20	schiff	schiff	NOUN
fnp-3341	61	21	.	.	PUNCT
fnp-3341	62	1	for	for	ADP
fnp-3341	62	2	immunohistochemistry	immunohistochemistry	NOUN
fnp-3341	62	3	,	,	PUNCT
fnp-3341	62	4	sections	section	NOUN
fnp-3341	62	5	were	be	AUX
fnp-3341	62	6	deparaffinized	deparaffinize	VERB
fnp-3341	62	7	using	use	VERB
fnp-3341	62	8	xylene	xylene	NOUN
fnp-3341	62	9	,	,	PUNCT
fnp-3341	62	10	and	and	CCONJ
fnp-3341	62	11	rehydrated	rehydrate	VERB
fnp-3341	62	12	through	through	ADP
fnp-3341	62	13	descending	descend	VERB
fnp-3341	62	14	alcohol	alcohol	NOUN
fnp-3341	62	15	concentrations	concentration	NOUN
fnp-3341	62	16	.	.	PUNCT
fnp-3341	63	1	endogenous	endogenous	ADJ
fnp-3341	63	2	peroxidase	peroxidase	NOUN
fnp-3341	63	3	activity	activity	NOUN
fnp-3341	63	4	was	be	AUX
fnp-3341	63	5	blocked	block	VERB
fnp-3341	63	6	by	by	ADP
fnp-3341	63	7	incubating	incubate	VERB
fnp-3341	63	8	the	the	DET
fnp-3341	63	9	slides	slide	NOUN
fnp-3341	63	10	for	for	ADP
fnp-3341	63	11	30	30	NUM
fnp-3341	63	12	min	min	NOUN
fnp-3341	63	13	in	in	ADP
fnp-3341	63	14	phosphate	phosphate	ADJ
fnp-3341	63	15	buffered	buffer	VERB
fnp-3341	63	16	saline	saline	NOUN
fnp-3341	63	17	(	(	PUNCT
fnp-3341	63	18	pbs	pbs	PROPN
fnp-3341	63	19	)	)	PUNCT
fnp-3341	63	20	containing	contain	VERB
fnp-3341	63	21	0.3	0.3	NUM
fnp-3341	63	22	%	%	NOUN
fnp-3341	63	23	h2o2	h2o2	NOUN
fnp-3341	63	24	.	.	NOUN
fnp-3341	63	25	heat	heat	NOUN
fnp-3341	63	26	-	-	PUNCT
fnp-3341	63	27	induced	induce	VERB
fnp-3341	63	28	antigen	antigen	NOUN
fnp-3341	63	29	retrieval	retrieval	NOUN
fnp-3341	63	30	was	be	AUX
fnp-3341	63	31	performed	perform	VERB
fnp-3341	63	32	in	in	ADP
fnp-3341	63	33	0.01	0.01	NUM
fnp-3341	63	34	m	m	NOUN
fnp-3341	63	35	citrate	citrate	NOUN
fnp-3341	63	36	buffer	buffer	NOUN
fnp-3341	63	37	(	(	PUNCT
fnp-3341	63	38	ph	ph	NOUN
fnp-3341	63	39	6.0	6.0	NUM
fnp-3341	63	40	)	)	PUNCT
fnp-3341	63	41	.	.	PUNCT
fnp-3341	64	1	after	after	ADP
fnp-3341	64	2	washing	wash	VERB
fnp-3341	64	3	in	in	ADP
fnp-3341	64	4	pbs	pbs	PROPN
fnp-3341	64	5	,	,	PUNCT
fnp-3341	64	6	the	the	DET
fnp-3341	64	7	slides	slide	NOUN
fnp-3341	64	8	were	be	AUX
fnp-3341	64	9	incubated	incubate	VERB
fnp-3341	64	10	overnight	overnight	ADV
fnp-3341	64	11	at	at	ADP
fnp-3341	64	12	rt	rt	PROPN
fnp-3341	64	13	with	with	ADP
fnp-3341	64	14	primary	primary	ADJ
fnp-3341	64	15	antibodies	antibody	NOUN
fnp-3341	64	16	against	against	ADP
fnp-3341	64	17	p	p	NOUN
fnp-3341	64	18	-	-	PUNCT
fnp-3341	64	19	gp	gp	NOUN
fnp-3341	64	20	(	(	PUNCT
fnp-3341	64	21	1:20	1:20	NUM
fnp-3341	64	22	;	;	PUNCT
fnp-3341	64	23	millipore	millipore	PROPN
fnp-3341	64	24	,	,	PUNCT
fnp-3341	64	25	ca	ca	PROPN
fnp-3341	64	26	,	,	PUNCT
fnp-3341	64	27	usa	usa	PROPN
fnp-3341	64	28	)	)	PUNCT
fnp-3341	64	29	,	,	PUNCT
fnp-3341	64	30	bcrp	bcrp	ADV
fnp-3341	64	31	(	(	PUNCT
fnp-3341	64	32	1:40	1:40	NUM
fnp-3341	64	33	;	;	PUNCT
fnp-3341	64	34	abcam	abcam	PROPN
fnp-3341	64	35	,	,	PUNCT
fnp-3341	64	36	cambridge	cambridge	PROPN
fnp-3341	64	37	,	,	PUNCT
fnp-3341	64	38	uk	uk	PROPN
fnp-3341	64	39	)	)	PUNCT
fnp-3341	64	40	,	,	PUNCT
fnp-3341	64	41	pre	pre	ADJ
fnp-3341	64	42	-	-	ADJ
fnp-3341	64	43	albumin	albumin	ADJ
fnp-3341	64	44	(	(	PUNCT
fnp-3341	64	45	1:50,000	1:50,000	NUM
fnp-3341	64	46	,	,	PUNCT
fnp-3341	64	47	dako	dako	PROPN
fnp-3341	64	48	,	,	PUNCT
fnp-3341	64	49	glostrup	glostrup	NOUN
fnp-3341	64	50	,	,	PUNCT
fnp-3341	64	51	denmark	denmark	NOUN
fnp-3341	64	52	)	)	PUNCT
fnp-3341	64	53	,	,	PUNCT
fnp-3341	64	54	fibrinogen	fibrinogen	X
fnp-3341	64	55	(	(	PUNCT
fnp-3341	64	56	1:1,600	1:1,600	PROPN
fnp-3341	64	57	,	,	PUNCT
fnp-3341	64	58	dako	dako	PROPN
fnp-3341	64	59	,	,	PUNCT
fnp-3341	64	60	glostrup	glostrup	NOUN
fnp-3341	64	61	,	,	PUNCT
fnp-3341	64	62	denmark	denmark	NOUN
fnp-3341	64	63	)	)	PUNCT
fnp-3341	64	64	,	,	PUNCT
fnp-3341	64	65	igg	igg	PROPN
fnp-3341	64	66	(	(	PUNCT
fnp-3341	64	67	1:800	1:800	PROPN
fnp-3341	64	68	,	,	PUNCT
fnp-3341	64	69	dako	dako	PROPN
fnp-3341	64	70	,	,	PUNCT
fnp-3341	64	71	glostrup	glostrup	NOUN
fnp-3341	64	72	,	,	PUNCT
fnp-3341	64	73	denmark	denmark	NOUN
fnp-3341	64	74	)	)	PUNCT
fnp-3341	64	75	and	and	CCONJ
fnp-3341	64	76	hypoxia	hypoxia	NOUN
fnp-3341	64	77	-	-	PUNCT
fnp-3341	64	78	inducible	inducible	ADJ
fnp-3341	64	79	factor	factor	NOUN
fnp-3341	64	80	1α	1α	NUM
fnp-3341	64	81	(	(	PUNCT
fnp-3341	64	82	hif-1α	hif-1α	NOUN
fnp-3341	64	83	;	;	PUNCT
fnp-3341	64	84	1:40	1:40	NUM
fnp-3341	64	85	,	,	PUNCT
fnp-3341	64	86	cayman	cayman	NOUN
fnp-3341	64	87	chemical	chemical	PROPN
fnp-3341	64	88	,	,	PUNCT
fnp-3341	64	89	michigan	michigan	PROPN
fnp-3341	64	90	,	,	PUNCT
fnp-3341	64	91	usa	usa	PROPN
fnp-3341	64	92	)	)	PUNCT
fnp-3341	64	93	.	.	PUNCT
fnp-3341	65	1	the	the	DET
fnp-3341	65	2	next	next	ADJ
fnp-3341	65	3	day	day	NOUN
fnp-3341	65	4	,	,	PUNCT
fnp-3341	65	5	slides	slide	NOUN
fnp-3341	65	6	were	be	AUX
fnp-3341	65	7	incubated	incubate	VERB
fnp-3341	65	8	with	with	ADP
fnp-3341	65	9	ready	ready	ADJ
fnp-3341	65	10	-	-	PUNCT
fnp-3341	65	11	to	to	PART
fnp-3341	65	12	-	-	PUNCT
fnp-3341	65	13	use	use	VERB
fnp-3341	65	14	envision	envision	NOUN
fnp-3341	65	15	™	™	NOUN
fnp-3341	65	16	-hrp	-hrp	NOUN
fnp-3341	65	17	(	(	PUNCT
fnp-3341	65	18	dako	dako	PROPN
fnp-3341	65	19	,	,	PUNCT
fnp-3341	65	20	glostrup	glostrup	NOUN
fnp-3341	65	21	,	,	PUNCT
fnp-3341	65	22	denmark	denmark	PROPN
fnp-3341	65	23	)	)	PUNCT
fnp-3341	65	24	for	for	ADP
fnp-3341	65	25	1	1	NUM
fnp-3341	65	26	hour	hour	NOUN
fnp-3341	65	27	at	at	ADP
fnp-3341	65	28	rt	rt	NOUN
fnp-3341	65	29	and	and	CCONJ
fnp-3341	65	30	visualized	visualize	VERB
fnp-3341	65	31	with	with	ADP
fnp-3341	65	32	3,3'diaminobenzidine	3,3'diaminobenzidine	NUM
fnp-3341	65	33	(	(	PUNCT
fnp-3341	65	34	dab+	dab+	PROPN
fnp-3341	65	35	dako	dako	PROPN
fnp-3341	65	36	;	;	PUNCT
fnp-3341	65	37	1:50	1:50	NUM
fnp-3341	65	38	,	,	PUNCT
fnp-3341	65	39	glostrup	glostrup	NOUN
fnp-3341	65	40	,	,	PUNCT
fnp-3341	65	41	denmark	denmark	PROPN
fnp-3341	65	42	)	)	PUNCT
fnp-3341	65	43	for	for	ADP
fnp-3341	65	44	10	10	NUM
fnp-3341	65	45	min	min	NOUN
fnp-3341	65	46	.	.	PUNCT
fnp-3341	66	1	the	the	DET
fnp-3341	66	2	slides	slide	NOUN
fnp-3341	66	3	were	be	AUX
fnp-3341	66	4	counterstained	counterstaine	VERB
fnp-3341	66	5	with	with	ADP
fnp-3341	66	6	hematoxylin	hematoxylin	PROPN
fnp-3341	66	7	for	for	ADP
fnp-3341	66	8	1	1	NUM
fnp-3341	66	9	min	min	NOUN
fnp-3341	66	10	and	and	CCONJ
fnp-3341	66	11	mounted	mount	VERB
fnp-3341	66	12	with	with	ADP
fnp-3341	66	13	quick	quick	ADJ
fnp-3341	66	14	-	-	PUNCT
fnp-3341	66	15	d	d	NOUN
fnp-3341	66	16	mounting	mount	VERB
fnp-3341	66	17	medium	medium	NOUN
fnp-3341	66	18	(	(	PUNCT
fnp-3341	66	19	klinipath	klinipath	NOUN
fnp-3341	66	20	,	,	PUNCT
fnp-3341	66	21	duiven	duiven	VERB
fnp-3341	66	22	,	,	PUNCT
fnp-3341	66	23	the	the	DET
fnp-3341	66	24	netherlands	netherlands	PROPN
fnp-3341	66	25	)	)	PUNCT
fnp-3341	66	26	.	.	PUNCT
fnp-3341	67	1	data	datum	NOUN
fnp-3341	67	2	analysis	analysis	NOUN
fnp-3341	67	3	sections	section	NOUN
fnp-3341	67	4	were	be	AUX
fnp-3341	67	5	imaged	image	VERB
fnp-3341	67	6	using	use	VERB
fnp-3341	67	7	a	a	DET
fnp-3341	67	8	leica	leica	PROPN
fnp-3341	67	9	dm6000b	dm6000b	PROPN
fnp-3341	67	10	microscope	microscope	NOUN
fnp-3341	67	11	(	(	PUNCT
fnp-3341	67	12	400x	400x	ADV
fnp-3341	67	13	magnification	magnification	NOUN
fnp-3341	67	14	;	;	PUNCT
fnp-3341	67	15	leica	leica	PROPN
fnp-3341	67	16	microsystems	microsystems	PROPN
fnp-3341	67	17	bv	bv	PROPN
fnp-3341	67	18	,	,	PUNCT
fnp-3341	67	19	rijswijk	rijswijk	NOUN
fnp-3341	67	20	,	,	PUNCT
fnp-3341	67	21	the	the	DET
fnp-3341	67	22	netherlands	netherlands	PROPN
fnp-3341	67	23	)	)	PUNCT
fnp-3341	67	24	.	.	PUNCT
fnp-3341	68	1	from	from	ADP
fnp-3341	68	2	each	each	DET
fnp-3341	68	3	tissue	tissue	NOUN
fnp-3341	68	4	slide	slide	NOUN
fnp-3341	68	5	,	,	PUNCT
fnp-3341	68	6	ten	ten	NUM
fnp-3341	68	7	images	image	NOUN
fnp-3341	68	8	were	be	AUX
fnp-3341	68	9	made	make	VERB
fnp-3341	68	10	.	.	PUNCT
fnp-3341	69	1	a	a	DET
fnp-3341	69	2	semi	semi	ADJ
fnp-3341	69	3	-	-	ADJ
fnp-3341	69	4	quantitative	quantitative	ADJ
fnp-3341	69	5	analysis	analysis	NOUN
fnp-3341	69	6	of	of	ADP
fnp-3341	69	7	the	the	DET
fnp-3341	69	8	bbb	bbb	NOUN
fnp-3341	69	9	staining	stain	VERB
fnp-3341	69	10	,	,	PUNCT
fnp-3341	69	11	comparing	compare	VERB
fnp-3341	69	12	dipg	dipg	NOUN
fnp-3341	69	13	samples	sample	NOUN
fnp-3341	69	14	with	with	ADP
fnp-3341	69	15	control	control	NOUN
fnp-3341	69	16	samples	sample	NOUN
fnp-3341	69	17	,	,	PUNCT
fnp-3341	69	18	was	be	AUX
fnp-3341	69	19	done	do	VERB
fnp-3341	69	20	by	by	ADP
fnp-3341	69	21	two	two	NUM
fnp-3341	69	22	independent	independent	ADJ
fnp-3341	69	23	reviewers	reviewer	NOUN
fnp-3341	69	24	(	(	PUNCT
fnp-3341	69	25	fe	fe	X
fnp-3341	69	26	and	and	CCONJ
fnp-3341	69	27	rh	rh	PROPN
fnp-3341	69	28	)	)	PUNCT
fnp-3341	69	29	using	use	VERB
fnp-3341	69	30	the	the	DET
fnp-3341	69	31	leica	leica	PROPN
fnp-3341	69	32	application	application	NOUN
fnp-3341	69	33	suite	suite	NOUN
fnp-3341	69	34	x	x	X
fnp-3341	69	35	:	:	PUNCT
fnp-3341	69	36	las	las	NOUN
fnp-3341	69	37	x	x	PROPN
fnp-3341	69	38	version	version	PROPN
fnp-3341	69	39	3.1.5.16308	3.1.5.16308	NOUN
fnp-3341	69	40	.	.	PUNCT
fnp-3341	70	1	the	the	DET
fnp-3341	70	2	vascular	vascular	ADJ
fnp-3341	70	3	density	density	NOUN
fnp-3341	70	4	was	be	AUX
fnp-3341	70	5	assessed	assess	VERB
fnp-3341	70	6	on	on	ADP
fnp-3341	70	7	claudin-5	claudin-5	ADV
fnp-3341	70	8	-	-	PUNCT
fnp-3341	70	9	stained	stain	VERB
fnp-3341	70	10	tissue	tissue	NOUN
fnp-3341	70	11	sections	section	NOUN
fnp-3341	70	12	by	by	ADP
fnp-3341	70	13	counting	count	VERB
fnp-3341	70	14	the	the	DET
fnp-3341	70	15	number	number	NOUN
fnp-3341	70	16	of	of	ADP
fnp-3341	70	17	blood	blood	NOUN
fnp-3341	70	18	vessels	vessel	NOUN
fnp-3341	70	19	per	per	ADP
fnp-3341	70	20	mm2	mm2	NOUN
fnp-3341	70	21	.	.	PUNCT
fnp-3341	71	1	the	the	DET
fnp-3341	71	2	luminal	luminal	ADJ
fnp-3341	71	3	diameter	diameter	NOUN
fnp-3341	71	4	of	of	ADP
fnp-3341	71	5	the	the	DET
fnp-3341	71	6	blood	blood	NOUN
fnp-3341	71	7	vessels	vessel	NOUN
fnp-3341	71	8	was	be	AUX
fnp-3341	71	9	measured	measure	VERB
fnp-3341	71	10	with	with	ADP
fnp-3341	71	11	the	the	DET
fnp-3341	71	12	leica	leica	PROPN
fnp-3341	71	13	application	application	NOUN
fnp-3341	71	14	suite	suite	NOUN
fnp-3341	71	15	x	x	X
fnp-3341	71	16	:	:	PUNCT
fnp-3341	71	17	las	las	NOUN
fnp-3341	71	18	x	x	PROPN
fnp-3341	71	19	version	version	PROPN
fnp-3341	71	20	3.1.5.16308	3.1.5.16308	NOUN
fnp-3341	71	21	.	.	PUNCT
fnp-3341	72	1	statistics	statistic	NOUN
fnp-3341	72	2	data	datum	NOUN
fnp-3341	72	3	were	be	AUX
fnp-3341	72	4	analyzed	analyze	VERB
fnp-3341	72	5	using	use	VERB
fnp-3341	72	6	an	an	DET
fnp-3341	72	7	independent	independent	ADJ
fnp-3341	72	8	samples	sample	NOUN
fnp-3341	72	9	t	t	NOUN
fnp-3341	72	10	-	-	PUNCT
fnp-3341	72	11	test	test	NOUN
fnp-3341	72	12	(	(	PUNCT
fnp-3341	72	13	p	p	NOUN
fnp-3341	72	14	-	-	PUNCT
fnp-3341	72	15	value	value	NOUN
fnp-3341	72	16	=	=	NOUN
fnp-3341	72	17	0.05	0.05	NUM
fnp-3341	72	18	)	)	PUNCT
fnp-3341	72	19	using	use	VERB
fnp-3341	72	20	ibm	ibm	PROPN
fnp-3341	72	21	spss	spss	PROPN
fnp-3341	72	22	statistics	statistics	PROPN
fnp-3341	72	23	version	version	PROPN
fnp-3341	72	24	26	26	NUM
fnp-3341	72	25	.	.	PUNCT
fnp-3341	73	1	the	the	DET
fnp-3341	73	2	levene	levene	NOUN
fnp-3341	73	3	’s	’s	PART
fnp-3341	73	4	test	test	NOUN
fnp-3341	73	5	of	of	ADP
fnp-3341	73	6	equality	equality	NOUN
fnp-3341	73	7	of	of	ADP
fnp-3341	73	8	variance	variance	NOUN
fnp-3341	73	9	was	be	AUX
fnp-3341	73	10	used	use	VERB
fnp-3341	73	11	to	to	PART
fnp-3341	73	12	first	first	ADV
fnp-3341	73	13	test	test	VERB
fnp-3341	73	14	the	the	DET
fnp-3341	73	15	assumption	assumption	NOUN
fnp-3341	73	16	of	of	ADP
fnp-3341	73	17	homogeneity	homogeneity	NOUN
fnp-3341	73	18	or	or	CCONJ
fnp-3341	73	19	variance	variance	NOUN
fnp-3341	73	20	between	between	ADP
fnp-3341	73	21	the	the	DET
fnp-3341	73	22	groups	group	NOUN
fnp-3341	73	23	(	(	PUNCT
fnp-3341	73	24	p	p	NOUN
fnp-3341	73	25	-	-	PUNCT
fnp-3341	73	26	value	value	NOUN
fnp-3341	73	27	=	=	NOUN
fnp-3341	73	28	0.05	0.05	NUM
fnp-3341	73	29	)	)	PUNCT
fnp-3341	73	30	.	.	PUNCT
fnp-3341	74	1	when	when	SCONJ
fnp-3341	74	2	equal	equal	ADJ
fnp-3341	74	3	variances	variance	NOUN
fnp-3341	74	4	were	be	AUX
fnp-3341	74	5	assumed	assume	VERB
fnp-3341	74	6	,	,	PUNCT
fnp-3341	74	7	pooled	pool	VERB
fnp-3341	74	8	estimates	estimate	NOUN
fnp-3341	74	9	were	be	AUX
fnp-3341	74	10	used	use	VERB
fnp-3341	74	11	for	for	ADP
fnp-3341	74	12	the	the	DET
fnp-3341	74	13	independent	independent	ADJ
fnp-3341	74	14	t	t	PROPN
fnp-3341	74	15	-	-	PUNCT
fnp-3341	74	16	test	test	NOUN
fnp-3341	74	17	statistics	statistic	NOUN
fnp-3341	74	18	.	.	PUNCT
fnp-3341	75	1	when	when	SCONJ
fnp-3341	75	2	equal	equal	ADJ
fnp-3341	75	3	variances	variance	NOUN
fnp-3341	75	4	were	be	AUX
fnp-3341	75	5	not	not	PART
fnp-3341	75	6	assumed	assume	VERB
fnp-3341	75	7	,	,	PUNCT
fnp-3341	75	8	unpooled	unpoole	VERB
fnp-3341	75	9	data	datum	NOUN
fnp-3341	75	10	and	and	CCONJ
fnp-3341	75	11	an	an	DET
fnp-3341	75	12	adjustment	adjustment	NOUN
fnp-3341	75	13	to	to	ADP
fnp-3341	75	14	the	the	DET
fnp-3341	75	15	degree	degree	NOUN
fnp-3341	75	16	of	of	ADP
fnp-3341	75	17	freedom	freedom	NOUN
fnp-3341	75	18	(	(	PUNCT
fnp-3341	75	19	df	df	NOUN
fnp-3341	75	20	)	)	PUNCT
fnp-3341	75	21	were	be	AUX
fnp-3341	75	22	used	use	VERB
fnp-3341	75	23	for	for	ADP
fnp-3341	75	24	the	the	DET
fnp-3341	75	25	independent	independent	ADJ
fnp-3341	75	26	t	t	PROPN
fnp-3341	75	27	-	-	PUNCT
fnp-3341	75	28	test	test	NOUN
fnp-3341	75	29	statistics	statistic	NOUN
fnp-3341	75	30	.	.	PUNCT
fnp-3341	76	1	results	result	NOUN
fnp-3341	76	2	immunohistochemistry	immunohistochemistry	NOUN
fnp-3341	76	3	figure	figure	NOUN
fnp-3341	76	4	1	1	NUM
fnp-3341	76	5	shows	show	VERB
fnp-3341	76	6	typical	typical	ADJ
fnp-3341	76	7	dipg	dipg	NOUN
fnp-3341	76	8	mri	mri	NOUN
fnp-3341	76	9	features	feature	NOUN
fnp-3341	76	10	with	with	ADP
fnp-3341	76	11	enlargement	enlargement	NOUN
fnp-3341	76	12	of	of	ADP
fnp-3341	76	13	the	the	DET
fnp-3341	76	14	pons	pon	NOUN
fnp-3341	76	15	and	and	CCONJ
fnp-3341	76	16	contrast	contrast	VERB
fnp-3341	76	17	enhancement	enhancement	NOUN
fnp-3341	76	18	.	.	PUNCT
fnp-3341	77	1	gross	gross	ADJ
fnp-3341	77	2	inspection	inspection	NOUN
fnp-3341	77	3	confirms	confirm	VERB
fnp-3341	77	4	the	the	DET
fnp-3341	77	5	presence	presence	NOUN
fnp-3341	77	6	of	of	ADP
fnp-3341	77	7	a	a	DET
fnp-3341	77	8	partly	partly	ADV
fnp-3341	77	9	necrotic	necrotic	ADJ
fnp-3341	77	10	and	and	CCONJ
fnp-3341	77	11	hemorrhagic	hemorrhagic	ADJ
fnp-3341	77	12	tumor	tumor	NOUN
fnp-3341	77	13	center	center	NOUN
fnp-3341	77	14	in	in	ADP
fnp-3341	77	15	the	the	DET
fnp-3341	77	16	pons	pon	NOUN
fnp-3341	77	17	.	.	PUNCT
fnp-3341	78	1	microscopic	microscopic	ADJ
fnp-3341	78	2	examination	examination	NOUN
fnp-3341	78	3	shows	show	VERB
fnp-3341	78	4	variability	variability	NOUN
fnp-3341	78	5	of	of	ADP
fnp-3341	78	6	tumor	tumor	NOUN
fnp-3341	78	7	cell	cell	NOUN
fnp-3341	78	8	morphology	morphology	NOUN
fnp-3341	78	9	,	,	PUNCT
fnp-3341	78	10	ranging	range	VERB
fnp-3341	78	11	from	from	ADP
fnp-3341	78	12	grade	grade	NOUN
fnp-3341	78	13	i	i	PRON
fnp-3341	78	14	to	to	PART
fnp-3341	78	15	grade	grade	VERB
fnp-3341	78	16	iv	iv	NUM
fnp-3341	78	17	according	accord	VERB
fnp-3341	78	18	to	to	ADP
fnp-3341	78	19	the	the	DET
fnp-3341	78	20	2016	2016	NUM
fnp-3341	78	21	who	who	PRON
fnp-3341	78	22	classification	classification	NOUN
fnp-3341	78	23	of	of	ADP
fnp-3341	78	24	cns	cns	NOUN
fnp-3341	78	25	tumors	tumor	NOUN
fnp-3341	78	26	.	.	PUNCT
fnp-3341	79	1	tumor	tumor	NOUN
fnp-3341	79	2	areas	area	NOUN
fnp-3341	79	3	were	be	AUX
fnp-3341	79	4	recognized	recognize	VERB
fnp-3341	79	5	based	base	VERB
fnp-3341	79	6	on	on	ADP
fnp-3341	79	7	cell	cell	NOUN
fnp-3341	79	8	density	density	NOUN
fnp-3341	79	9	,	,	PUNCT
fnp-3341	79	10	the	the	DET
fnp-3341	79	11	presence	presence	NOUN
fnp-3341	79	12	of	of	ADP
fnp-3341	79	13	(	(	PUNCT
fnp-3341	79	14	atypical	atypical	ADJ
fnp-3341	79	15	)	)	PUNCT
fnp-3341	79	16	mitotic	mitotic	ADJ
fnp-3341	79	17	figures	figure	NOUN
fnp-3341	79	18	and	and	CCONJ
fnp-3341	79	19	features	feature	NOUN
fnp-3341	79	20	of	of	ADP
fnp-3341	79	21	high	high	ADJ
fnp-3341	79	22	-	-	PUNCT
fnp-3341	79	23	grade	grade	NOUN
fnp-3341	79	24	glioma	glioma	NOUN
fnp-3341	79	25	,	,	PUNCT
fnp-3341	79	26	including	include	VERB
fnp-3341	79	27	necrosis	necrosis	NOUN
fnp-3341	79	28	and	and	CCONJ
fnp-3341	79	29	microvascular	microvascular	ADJ
fnp-3341	79	30	proliferation	proliferation	NOUN
fnp-3341	79	31	.	.	PUNCT
fnp-3341	80	1	in	in	ADP
fnp-3341	80	2	these	these	DET
fnp-3341	80	3	tumors	tumor	NOUN
fnp-3341	80	4	,	,	PUNCT
fnp-3341	80	5	the	the	DET
fnp-3341	80	6	integrity	integrity	NOUN
fnp-3341	80	7	of	of	ADP
fnp-3341	80	8	the	the	DET
fnp-3341	80	9	bbb	bbb	PROPN
fnp-3341	80	10	is	be	AUX
fnp-3341	80	11	compromised	compromise	VERB
fnp-3341	80	12	,	,	PUNCT
fnp-3341	80	13	as	as	SCONJ
fnp-3341	80	14	demonstrated	demonstrate	VERB
fnp-3341	80	15	by	by	ADP
fnp-3341	80	16	extravasation	extravasation	NOUN
fnp-3341	80	17	of	of	ADP
fnp-3341	80	18	pre	pre	ADJ
fnp-3341	80	19	-	-	ADJ
fnp-3341	80	20	albumin	albumin	ADJ
fnp-3341	80	21	,	,	PUNCT
fnp-3341	80	22	fibrinogen	fibrinogen	NOUN
fnp-3341	80	23	and	and	CCONJ
fnp-3341	80	24	igg	igg	PROPN
fnp-3341	80	25	.	.	PUNCT
fnp-3341	81	1	this	this	PRON
fnp-3341	81	2	corresponds	correspond	VERB
fnp-3341	81	3	with	with	ADP
fnp-3341	81	4	expression	expression	NOUN
fnp-3341	81	5	of	of	ADP
fnp-3341	81	6	hif-1α	hif-1α	NOUN
fnp-3341	81	7	,	,	PUNCT
fnp-3341	81	8	indicating	indicate	VERB
fnp-3341	81	9	tumor	tumor	NOUN
fnp-3341	81	10	hypoxia	hypoxia	NOUN
fnp-3341	81	11	.	.	PUNCT
fnp-3341	82	1	notably	notably	ADV
fnp-3341	82	2	,	,	PUNCT
fnp-3341	82	3	as	as	SCONJ
fnp-3341	82	4	expected	expect	VERB
fnp-3341	82	5	for	for	ADP
fnp-3341	82	6	a	a	DET
fnp-3341	82	7	heterogeneous	heterogeneous	ADJ
fnp-3341	82	8	tumor	tumor	NOUN
fnp-3341	82	9	such	such	ADJ
fnp-3341	82	10	as	as	ADP
fnp-3341	82	11	dipg	dipg	NOUN
fnp-3341	82	12	,	,	PUNCT
fnp-3341	82	13	the	the	DET
fnp-3341	82	14	density	density	NOUN
fnp-3341	82	15	of	of	ADP
fnp-3341	82	16	gfap	gfap	ADJ
fnp-3341	82	17	-	-	PUNCT
fnp-3341	82	18	expressing	express	VERB
fnp-3341	82	19	astrocytes	astrocyte	NOUN
fnp-3341	82	20	varied	varied	ADJ
fnp-3341	82	21	throughout	throughout	ADP
fnp-3341	82	22	the	the	DET
fnp-3341	82	23	tumor	tumor	NOUN
fnp-3341	82	24	20	20	NUM
fnp-3341	82	25	.	.	PUNCT
fnp-3341	83	1	additionally	additionally	ADV
fnp-3341	83	2	,	,	PUNCT
fnp-3341	83	3	tumor	tumor	NOUN
fnp-3341	83	4	cells	cell	NOUN
fnp-3341	83	5	were	be	AUX
fnp-3341	83	6	differentiated	differentiate	VERB
fnp-3341	83	7	from	from	ADP
fnp-3341	83	8	pre	pre	ADJ
fnp-3341	83	9	-	-	ADJ
fnp-3341	83	10	existing	existing	ADJ
fnp-3341	83	11	astrocytes	astrocyte	NOUN
fnp-3341	83	12	by	by	ADP
fnp-3341	83	13	their	their	PRON
fnp-3341	83	14	higher	high	ADJ
fnp-3341	83	15	expression	expression	NOUN
fnp-3341	83	16	levels	level	NOUN
fnp-3341	83	17	of	of	ADP
fnp-3341	83	18	gfap	gfap	ADJ
fnp-3341	83	19	,	,	PUNCT
fnp-3341	83	20	conceivably	conceivably	ADV
fnp-3341	83	21	also	also	ADV
fnp-3341	83	22	related	relate	VERB
fnp-3341	83	23	to	to	ADP
fnp-3341	83	24	their	their	PRON
fnp-3341	83	25	less	less	ADV
fnp-3341	83	26	differentiated	differentiated	ADJ
fnp-3341	83	27	state	state	NOUN
fnp-3341	83	28	20	20	NUM
fnp-3341	83	29	.	.	PUNCT
fnp-3341	84	1	figure	figure	NOUN
fnp-3341	84	2	2	2	NUM
fnp-3341	84	3	:	:	PUNCT
fnp-3341	84	4	expression	expression	NOUN
fnp-3341	84	5	of	of	ADP
fnp-3341	84	6	tight	tight	ADJ
fnp-3341	84	7	junction	junction	NOUN
fnp-3341	84	8	proteins	protein	NOUN
fnp-3341	84	9	claudin-5	claudin-5	PRON
fnp-3341	84	10	and	and	CCONJ
fnp-3341	84	11	zonula	zonula	NOUN
fnp-3341	84	12	occludens-1	occludens-1	NUM
fnp-3341	84	13	(	(	PUNCT
fnp-3341	84	14	zo-1	zo-1	NUM
fnp-3341	84	15	)	)	PUNCT
fnp-3341	84	16	in	in	ADP
fnp-3341	84	17	dipg	dipg	PROPN
fnp-3341	84	18	pre	pre	ADJ
fnp-3341	84	19	-	-	ADJ
fnp-3341	84	20	treatment	treatment	ADJ
fnp-3341	84	21	biopsy	biopsy	NOUN
fnp-3341	84	22	and	and	CCONJ
fnp-3341	84	23	post	post	ADJ
fnp-3341	84	24	-	-	ADJ
fnp-3341	84	25	mortem	mortem	ADJ
fnp-3341	84	26	autopsy	autopsy	ADJ
fnp-3341	84	27	samples	sample	NOUN
fnp-3341	84	28	.	.	PUNCT
fnp-3341	85	1	in	in	ADP
fnp-3341	85	2	controls	control	NOUN
fnp-3341	85	3	,	,	PUNCT
fnp-3341	85	4	claudin-5	claudin-5	PROPN
fnp-3341	85	5	and	and	CCONJ
fnp-3341	85	6	zo-1	zo-1	NUM
fnp-3341	85	7	are	be	AUX
fnp-3341	85	8	sharply	sharply	ADV
fnp-3341	85	9	defined	define	VERB
fnp-3341	85	10	and	and	CCONJ
fnp-3341	85	11	have	have	VERB
fnp-3341	85	12	a	a	DET
fnp-3341	85	13	segmented	segment	VERB
fnp-3341	85	14	pattern	pattern	NOUN
fnp-3341	85	15	(	(	PUNCT
fnp-3341	85	16	a	a	PRON
fnp-3341	85	17	and	and	CCONJ
fnp-3341	85	18	d	d	NOUN
fnp-3341	85	19	)	)	PUNCT
fnp-3341	85	20	.	.	PUNCT
fnp-3341	86	1	claudin-5	claudin-5	PRON
fnp-3341	86	2	and	and	CCONJ
fnp-3341	86	3	zo-1	zo-1	NUM
fnp-3341	86	4	show	show	VERB
fnp-3341	86	5	reduced	reduce	VERB
fnp-3341	86	6	expression	expression	NOUN
fnp-3341	86	7	in	in	ADP
fnp-3341	86	8	dipg	dipg	NOUN
fnp-3341	86	9	samples	sample	NOUN
fnp-3341	86	10	(	(	PUNCT
fnp-3341	86	11	b	b	X
fnp-3341	86	12	,	,	PUNCT
fnp-3341	86	13	c	c	X
fnp-3341	86	14	,	,	PUNCT
fnp-3341	86	15	e	e	NOUN
fnp-3341	86	16	,	,	PUNCT
fnp-3341	86	17	f	f	NOUN
fnp-3341	86	18	)	)	PUNCT
fnp-3341	86	19	.	.	PUNCT
fnp-3341	87	1	please	please	INTJ
fnp-3341	87	2	note	note	VERB
fnp-3341	87	3	the	the	DET
fnp-3341	87	4	non	non	ADJ
fnp-3341	87	5	-	-	ADJ
fnp-3341	87	6	activated	activated	ADJ
fnp-3341	87	7	state	state	NOUN
fnp-3341	87	8	of	of	ADP
fnp-3341	87	9	gfap	gfap	ADJ
fnp-3341	87	10	-	-	PUNCT
fnp-3341	87	11	expressing	express	VERB
fnp-3341	87	12	astrocytes	astrocyte	NOUN
fnp-3341	87	13	in	in	ADP
fnp-3341	87	14	control	control	NOUN
fnp-3341	87	15	tissue	tissue	NOUN
fnp-3341	87	16	.	.	PUNCT
fnp-3341	88	1	(	(	PUNCT
fnp-3341	88	2	blue	blue	ADJ
fnp-3341	88	3	:	:	PUNCT
fnp-3341	88	4	nuclei	nucleus	NOUN
fnp-3341	88	5	;	;	PUNCT
fnp-3341	88	6	green	green	ADJ
fnp-3341	88	7	:	:	PUNCT
fnp-3341	88	8	astrocytes	astrocyte	NOUN
fnp-3341	88	9	;	;	PUNCT
fnp-3341	88	10	red	red	ADJ
fnp-3341	88	11	:	:	PUNCT
fnp-3341	88	12	claudin-5	claudin-5	NUM
fnp-3341	88	13	or	or	CCONJ
fnp-3341	88	14	zo-1	zo-1	NUM
fnp-3341	88	15	;	;	PUNCT
fnp-3341	88	16	scale	scale	NOUN
fnp-3341	88	17	bar	bar	NOUN
fnp-3341	88	18	:	:	PUNCT
fnp-3341	88	19	5	5	NUM
fnp-3341	88	20	µm	µm	NOUN
fnp-3341	88	21	)	)	PUNCT
fnp-3341	88	22	figure	figure	NOUN
fnp-3341	88	23	3	3	NUM
fnp-3341	88	24	:	:	PUNCT
fnp-3341	88	25	expression	expression	NOUN
fnp-3341	88	26	of	of	ADP
fnp-3341	88	27	basement	basement	NOUN
fnp-3341	88	28	membrane	membrane	NOUN
fnp-3341	88	29	component	component	NOUN
fnp-3341	88	30	laminin	laminin	NOUN
fnp-3341	88	31	in	in	ADP
fnp-3341	88	32	dipg	dipg	NOUN
fnp-3341	88	33	pre	pre	ADJ
fnp-3341	88	34	-	-	ADJ
fnp-3341	88	35	treatment	treatment	ADJ
fnp-3341	88	36	biopsy	biopsy	NOUN
fnp-3341	88	37	and	and	CCONJ
fnp-3341	88	38	post	post	ADJ
fnp-3341	88	39	-	-	ADJ
fnp-3341	88	40	mortem	mortem	ADJ
fnp-3341	88	41	autopsy	autopsy	ADJ
fnp-3341	88	42	samples	sample	NOUN
fnp-3341	88	43	.	.	PUNCT
fnp-3341	89	1	in	in	ADP
fnp-3341	89	2	controls	control	NOUN
fnp-3341	89	3	(	(	PUNCT
fnp-3341	89	4	a	a	DET
fnp-3341	89	5	-	-	PUNCT
fnp-3341	89	6	c	c	NOUN
fnp-3341	89	7	)	)	PUNCT
fnp-3341	89	8	,	,	PUNCT
fnp-3341	89	9	laminin	laminin	NOUN
fnp-3341	89	10	shows	show	VERB
fnp-3341	89	11	a	a	DET
fnp-3341	89	12	continuous	continuous	ADJ
fnp-3341	89	13	pattern	pattern	NOUN
fnp-3341	89	14	.	.	PUNCT
fnp-3341	90	1	laminin	laminin	NOUN
fnp-3341	90	2	expression	expression	NOUN
fnp-3341	90	3	was	be	AUX
fnp-3341	90	4	reduced	reduce	VERB
fnp-3341	90	5	at	at	ADP
fnp-3341	90	6	the	the	DET
fnp-3341	90	7	glial	glial	ADJ
fnp-3341	90	8	basement	basement	NOUN
fnp-3341	90	9	membrane	membrane	NOUN
fnp-3341	90	10	in	in	ADP
fnp-3341	90	11	both	both	DET
fnp-3341	90	12	dipg	dipg	NOUN
fnp-3341	90	13	biopsy	biopsy	NOUN
fnp-3341	90	14	(	(	PUNCT
fnp-3341	90	15	d	d	X
fnp-3341	90	16	-	-	PUNCT
fnp-3341	90	17	f	f	NOUN
fnp-3341	90	18	)	)	PUNCT
fnp-3341	90	19	and	and	CCONJ
fnp-3341	90	20	autopsy	autopsy	ADJ
fnp-3341	90	21	samples	sample	NOUN
fnp-3341	90	22	(	(	PUNCT
fnp-3341	90	23	g	g	NOUN
fnp-3341	90	24	-	-	PUNCT
fnp-3341	90	25	i	i	NOUN
fnp-3341	90	26	)	)	PUNCT
fnp-3341	90	27	.	.	PUNCT
fnp-3341	91	1	this	this	PRON
fnp-3341	91	2	was	be	AUX
fnp-3341	91	3	also	also	ADV
fnp-3341	91	4	observed	observe	VERB
fnp-3341	91	5	in	in	ADP
fnp-3341	91	6	neovascularization	neovascularization	NOUN
fnp-3341	91	7	in	in	ADP
fnp-3341	91	8	autopsy	autopsy	ADJ
fnp-3341	91	9	samples	sample	NOUN
fnp-3341	91	10	(	(	PUNCT
fnp-3341	91	11	j	j	NOUN
fnp-3341	91	12	-	-	PROPN
fnp-3341	91	13	l	l	NOUN
fnp-3341	91	14	)	)	PUNCT
fnp-3341	91	15	.	.	PUNCT
fnp-3341	92	1	of	of	ADP
fnp-3341	92	2	note	note	NOUN
fnp-3341	92	3	:	:	PUNCT
fnp-3341	92	4	neovascular	neovascular	NOUN
fnp-3341	92	5	proliferation	proliferation	NOUN
fnp-3341	92	6	was	be	AUX
fnp-3341	92	7	not	not	PART
fnp-3341	92	8	detected	detect	VERB
fnp-3341	92	9	in	in	ADP
fnp-3341	92	10	biopsy	biopsy	NOUN
fnp-3341	92	11	samples	sample	NOUN
fnp-3341	92	12	.	.	PUNCT
fnp-3341	93	1	(	(	PUNCT
fnp-3341	93	2	blue	blue	ADJ
fnp-3341	93	3	:	:	PUNCT
fnp-3341	93	4	nuclei	nucleus	NOUN
fnp-3341	93	5	;	;	PUNCT
fnp-3341	93	6	green	green	ADJ
fnp-3341	93	7	:	:	PUNCT
fnp-3341	93	8	astrocytes	astrocyte	NOUN
fnp-3341	93	9	;	;	PUNCT
fnp-3341	93	10	red	red	ADJ
fnp-3341	93	11	:	:	PUNCT
fnp-3341	93	12	laminin	laminin	NOUN
fnp-3341	93	13	;	;	PUNCT
fnp-3341	93	14	scale	scale	NOUN
fnp-3341	93	15	bar	bar	NOUN
fnp-3341	93	16	:	:	PUNCT
fnp-3341	93	17	5	5	NUM
fnp-3341	93	18	µm	µm	NOUN
fnp-3341	93	19	)	)	PUNCT
fnp-3341	93	20	immunohistochemical	immunohistochemical	ADJ
fnp-3341	93	21	staining	staining	NOUN
fnp-3341	93	22	of	of	ADP
fnp-3341	93	23	claudin-5	claudin-5	PROPN
fnp-3341	93	24	,	,	PUNCT
fnp-3341	93	25	zo-1	zo-1	PRON
fnp-3341	93	26	,	,	PUNCT
fnp-3341	93	27	laminin	laminin	NOUN
fnp-3341	93	28	,	,	PUNCT
fnp-3341	93	29	pdgfr	pdgfr	NOUN
fnp-3341	93	30	-	-	PUNCT
fnp-3341	93	31	β	β	NOUN
fnp-3341	93	32	,	,	PUNCT
fnp-3341	93	33	p	p	NOUN
fnp-3341	93	34	-	-	PUNCT
fnp-3341	93	35	gp	gp	NOUN
fnp-3341	93	36	and	and	CCONJ
fnp-3341	93	37	bcrp	bcrp	PROPN
fnp-3341	93	38	were	be	AUX
fnp-3341	93	39	evaluable	evaluable	ADJ
fnp-3341	93	40	in	in	ADP
fnp-3341	93	41	all	all	DET
fnp-3341	93	42	samples	sample	NOUN
fnp-3341	93	43	.	.	PUNCT
fnp-3341	94	1	expression	expression	NOUN
fnp-3341	94	2	of	of	ADP
fnp-3341	94	3	tight	tight	ADJ
fnp-3341	94	4	junction	junction	NOUN
fnp-3341	94	5	proteins	protein	NOUN
fnp-3341	94	6	claudin-5	claudin-5	PRON
fnp-3341	94	7	and	and	CCONJ
fnp-3341	94	8	zo-1	zo-1	NUM
fnp-3341	94	9	was	be	AUX
fnp-3341	94	10	lower	low	ADJ
fnp-3341	94	11	at	at	ADP
fnp-3341	94	12	inspection	inspection	NOUN
fnp-3341	94	13	in	in	ADP
fnp-3341	94	14	all	all	DET
fnp-3341	94	15	dipg	dipg	NOUN
fnp-3341	94	16	biopsy	biopsy	NOUN
fnp-3341	94	17	and	and	CCONJ
fnp-3341	94	18	autopsy	autopsy	ADJ
fnp-3341	94	19	samples	sample	NOUN
fnp-3341	94	20	compared	compare	VERB
fnp-3341	94	21	to	to	PART
fnp-3341	94	22	control	control	VERB
fnp-3341	94	23	samples	sample	NOUN
fnp-3341	94	24	(	(	PUNCT
fnp-3341	94	25	figure	figure	NOUN
fnp-3341	94	26	2	2	NUM
fnp-3341	94	27	)	)	PUNCT
fnp-3341	94	28	.	.	PUNCT
fnp-3341	95	1	the	the	DET
fnp-3341	95	2	expression	expression	NOUN
fnp-3341	95	3	of	of	ADP
fnp-3341	95	4	basement	basement	NOUN
fnp-3341	95	5	membrane	membrane	NOUN
fnp-3341	95	6	protein	protein	NOUN
fnp-3341	95	7	laminin	laminin	NOUN
fnp-3341	95	8	was	be	AUX
fnp-3341	95	9	lower	low	ADJ
fnp-3341	95	10	at	at	ADP
fnp-3341	95	11	the	the	DET
fnp-3341	95	12	glial	glial	ADJ
fnp-3341	95	13	basement	basement	NOUN
fnp-3341	95	14	membrane	membrane	NOUN
fnp-3341	95	15	in	in	ADP
fnp-3341	95	16	dipg	dipg	PROPN
fnp-3341	95	17	biopsy	biopsy	NOUN
fnp-3341	95	18	and	and	CCONJ
fnp-3341	95	19	autopsy	autopsy	ADJ
fnp-3341	95	20	samples	sample	NOUN
fnp-3341	95	21	.	.	PUNCT
fnp-3341	96	1	interestingly	interestingly	ADV
fnp-3341	96	2	,	,	PUNCT
fnp-3341	96	3	this	this	PRON
fnp-3341	96	4	was	be	AUX
fnp-3341	96	5	observed	observe	VERB
fnp-3341	96	6	in	in	ADP
fnp-3341	96	7	both	both	DET
fnp-3341	96	8	pre	pre	ADJ
fnp-3341	96	9	-	-	ADJ
fnp-3341	96	10	existent	existent	ADJ
fnp-3341	96	11	vessels	vessel	NOUN
fnp-3341	96	12	within	within	ADP
fnp-3341	96	13	the	the	DET
fnp-3341	96	14	tumor	tumor	NOUN
fnp-3341	96	15	cells	cell	NOUN
fnp-3341	96	16	and	and	CCONJ
fnp-3341	96	17	in	in	ADP
fnp-3341	96	18	neovascular	neovascular	NOUN
fnp-3341	96	19	proliferation	proliferation	NOUN
fnp-3341	96	20	(	(	PUNCT
fnp-3341	96	21	figure	figure	NOUN
fnp-3341	96	22	3	3	NUM
fnp-3341	96	23	)	)	PUNCT
fnp-3341	96	24	.	.	PUNCT
fnp-3341	97	1	expression	expression	NOUN
fnp-3341	97	2	of	of	ADP
fnp-3341	97	3	pericyte	pericyte	NOUN
fnp-3341	97	4	marker	marker	NOUN
fnp-3341	97	5	pdgfr	pdgfr	NOUN
fnp-3341	97	6	-	-	PUNCT
fnp-3341	97	7	β	β	PROPN
fnp-3341	97	8	was	be	AUX
fnp-3341	97	9	also	also	ADV
fnp-3341	97	10	reduced	reduce	VERB
fnp-3341	97	11	in	in	ADP
fnp-3341	97	12	both	both	PRON
fnp-3341	97	13	dipg	dipg	NOUN
fnp-3341	97	14	biopsy	biopsy	NOUN
fnp-3341	97	15	and	and	CCONJ
fnp-3341	97	16	autopsy	autopsy	ADJ
fnp-3341	97	17	samples	sample	NOUN
fnp-3341	97	18	(	(	PUNCT
fnp-3341	97	19	figure	figure	NOUN
fnp-3341	97	20	4	4	NUM
fnp-3341	97	21	)	)	PUNCT
fnp-3341	97	22	.	.	PUNCT
fnp-3341	98	1	efflux	efflux	VERB
fnp-3341	98	2	transporter	transporter	NOUN
fnp-3341	98	3	p	p	NOUN
fnp-3341	98	4	-	-	PUNCT
fnp-3341	98	5	gp	gp	NOUN
fnp-3341	98	6	expression	expression	NOUN
fnp-3341	98	7	was	be	AUX
fnp-3341	98	8	lower	low	ADJ
fnp-3341	98	9	in	in	ADP
fnp-3341	98	10	dipg	dipg	PROPN
fnp-3341	98	11	biopsy	biopsy	NOUN
fnp-3341	98	12	and	and	CCONJ
fnp-3341	98	13	autopsy	autopsy	ADJ
fnp-3341	98	14	samples	sample	NOUN
fnp-3341	98	15	,	,	PUNCT
fnp-3341	98	16	whereas	whereas	SCONJ
fnp-3341	98	17	the	the	DET
fnp-3341	98	18	expression	expression	NOUN
fnp-3341	98	19	of	of	ADP
fnp-3341	98	20	bcrp	bcrp	ADV
fnp-3341	98	21	was	be	AUX
fnp-3341	98	22	not	not	PART
fnp-3341	98	23	different	different	ADJ
fnp-3341	98	24	in	in	ADP
fnp-3341	98	25	dipg	dipg	NOUN
fnp-3341	98	26	compared	compare	VERB
fnp-3341	98	27	to	to	ADP
fnp-3341	98	28	controls	control	NOUN
fnp-3341	98	29	(	(	PUNCT
fnp-3341	98	30	figure	figure	NOUN
fnp-3341	98	31	5	5	NUM
fnp-3341	98	32	)	)	PUNCT
fnp-3341	98	33	.	.	PUNCT
fnp-3341	99	1	figure	figure	VERB
fnp-3341	99	2	4	4	NUM
fnp-3341	99	3	:	:	PUNCT
fnp-3341	99	4	expression	expression	NOUN
fnp-3341	99	5	of	of	ADP
fnp-3341	99	6	pericyte	pericyte	NOUN
fnp-3341	99	7	marker	marker	NOUN
fnp-3341	99	8	pdgfr	pdgfr	NOUN
fnp-3341	99	9	-	-	PUNCT
fnp-3341	99	10	β	β	NOUN
fnp-3341	99	11	in	in	ADP
fnp-3341	99	12	dipg	dipg	PROPN
fnp-3341	99	13	pre	pre	ADJ
fnp-3341	99	14	-	-	ADJ
fnp-3341	99	15	treatment	treatment	ADJ
fnp-3341	99	16	biopsy	biopsy	NOUN
fnp-3341	99	17	and	and	CCONJ
fnp-3341	99	18	post	post	ADJ
fnp-3341	99	19	-	-	ADJ
fnp-3341	99	20	mortem	mortem	ADJ
fnp-3341	99	21	autopsy	autopsy	ADJ
fnp-3341	99	22	samples	sample	NOUN
fnp-3341	99	23	.	.	PUNCT
fnp-3341	100	1	in	in	ADP
fnp-3341	100	2	controls	control	NOUN
fnp-3341	100	3	(	(	PUNCT
fnp-3341	100	4	a	a	DET
fnp-3341	100	5	-	-	PUNCT
fnp-3341	100	6	c	c	NOUN
fnp-3341	100	7	)	)	PUNCT
fnp-3341	100	8	,	,	PUNCT
fnp-3341	100	9	pdgfr	pdgfr	ADJ
fnp-3341	100	10	-	-	PUNCT
fnp-3341	100	11	β	β	NOUN
fnp-3341	100	12	shows	show	VERB
fnp-3341	100	13	a	a	DET
fnp-3341	100	14	continuous	continuous	ADJ
fnp-3341	100	15	pattern	pattern	NOUN
fnp-3341	100	16	.	.	PUNCT
fnp-3341	101	1	expression	expression	NOUN
fnp-3341	101	2	of	of	ADP
fnp-3341	101	3	pdgfr	pdgfr	NOUN
fnp-3341	101	4	-	-	PUNCT
fnp-3341	101	5	β	β	PROPN
fnp-3341	101	6	was	be	AUX
fnp-3341	101	7	reduced	reduce	VERB
fnp-3341	101	8	in	in	ADP
fnp-3341	101	9	both	both	DET
fnp-3341	101	10	dipg	dipg	NOUN
fnp-3341	101	11	biopsy	biopsy	NOUN
fnp-3341	101	12	(	(	PUNCT
fnp-3341	101	13	d	d	X
fnp-3341	101	14	-	-	PUNCT
fnp-3341	101	15	f	f	NOUN
fnp-3341	101	16	)	)	PUNCT
fnp-3341	101	17	and	and	CCONJ
fnp-3341	101	18	autopsy	autopsy	ADJ
fnp-3341	101	19	samples	sample	NOUN
fnp-3341	101	20	(	(	PUNCT
fnp-3341	101	21	g	g	NOUN
fnp-3341	101	22	-	-	PUNCT
fnp-3341	101	23	i	i	NOUN
fnp-3341	101	24	)	)	PUNCT
fnp-3341	101	25	.	.	PUNCT
fnp-3341	102	1	(	(	PUNCT
fnp-3341	102	2	blue	blue	ADJ
fnp-3341	102	3	:	:	PUNCT
fnp-3341	102	4	nuclei	nucleus	NOUN
fnp-3341	102	5	;	;	PUNCT
fnp-3341	102	6	green	green	ADJ
fnp-3341	102	7	:	:	PUNCT
fnp-3341	102	8	astrocytes	astrocyte	NOUN
fnp-3341	102	9	;	;	PUNCT
fnp-3341	102	10	red	red	ADJ
fnp-3341	102	11	:	:	PUNCT
fnp-3341	102	12	pdgfr	pdgfr	ADJ
fnp-3341	102	13	-	-	PUNCT
fnp-3341	102	14	β	β	NOUN
fnp-3341	102	15	;	;	PUNCT
fnp-3341	102	16	scale	scale	NOUN
fnp-3341	102	17	bar	bar	NOUN
fnp-3341	102	18	:	:	PUNCT
fnp-3341	102	19	5	5	NUM
fnp-3341	102	20	µm	µm	NOUN
fnp-3341	102	21	)	)	PUNCT
fnp-3341	102	22	.	.	PUNCT
fnp-3341	103	1	figure	figure	VERB
fnp-3341	103	2	5	5	NUM
fnp-3341	103	3	:	:	PUNCT
fnp-3341	103	4	expression	expression	NOUN
fnp-3341	103	5	of	of	ADP
fnp-3341	103	6	efflux	efflux	ADJ
fnp-3341	103	7	transporters	transporter	NOUN
fnp-3341	103	8	p	p	NOUN
fnp-3341	103	9	-	-	PUNCT
fnp-3341	103	10	gp	gp	NOUN
fnp-3341	103	11	and	and	CCONJ
fnp-3341	103	12	bcrp	bcrp	ADV
fnp-3341	103	13	in	in	ADP
fnp-3341	103	14	dipg	dipg	PROPN
fnp-3341	103	15	pre	pre	ADJ
fnp-3341	103	16	-	-	ADJ
fnp-3341	103	17	treatment	treatment	ADJ
fnp-3341	103	18	biopsy	biopsy	NOUN
fnp-3341	103	19	and	and	CCONJ
fnp-3341	103	20	post	post	ADJ
fnp-3341	103	21	-	-	ADJ
fnp-3341	103	22	mortem	mortem	ADJ
fnp-3341	103	23	autopsy	autopsy	ADJ
fnp-3341	103	24	samples	sample	NOUN
fnp-3341	103	25	.	.	PUNCT
fnp-3341	104	1	p	p	X
fnp-3341	104	2	-	-	PUNCT
fnp-3341	104	3	gp	gp	NOUN
fnp-3341	104	4	and	and	CCONJ
fnp-3341	104	5	bcrp	bcrp	ADV
fnp-3341	104	6	are	be	AUX
fnp-3341	104	7	sharply	sharply	ADV
fnp-3341	104	8	defined	define	VERB
fnp-3341	104	9	and	and	CCONJ
fnp-3341	104	10	have	have	VERB
fnp-3341	104	11	a	a	DET
fnp-3341	104	12	segmented	segment	VERB
fnp-3341	104	13	pattern	pattern	NOUN
fnp-3341	104	14	in	in	ADP
fnp-3341	104	15	controls	control	NOUN
fnp-3341	104	16	(	(	PUNCT
fnp-3341	104	17	a	a	PRON
fnp-3341	104	18	and	and	CCONJ
fnp-3341	104	19	d	d	NOUN
fnp-3341	104	20	)	)	PUNCT
fnp-3341	104	21	.	.	PUNCT
fnp-3341	105	1	expression	expression	NOUN
fnp-3341	105	2	of	of	ADP
fnp-3341	105	3	p	p	NOUN
fnp-3341	105	4	-	-	PUNCT
fnp-3341	105	5	gp	gp	NOUN
fnp-3341	105	6	was	be	AUX
fnp-3341	105	7	reduced	reduce	VERB
fnp-3341	105	8	in	in	ADP
fnp-3341	105	9	both	both	DET
fnp-3341	105	10	dipg	dipg	NOUN
fnp-3341	105	11	samples	sample	NOUN
fnp-3341	105	12	(	(	PUNCT
fnp-3341	105	13	b	b	NOUN
fnp-3341	105	14	and	and	CCONJ
fnp-3341	105	15	c	c	NOUN
fnp-3341	105	16	)	)	PUNCT
fnp-3341	105	17	.	.	PUNCT
fnp-3341	106	1	bcrp	bcrp	PROPN
fnp-3341	106	2	expression	expression	NOUN
fnp-3341	106	3	was	be	AUX
fnp-3341	106	4	unchanged	unchanged	ADJ
fnp-3341	106	5	in	in	ADP
fnp-3341	106	6	dipg	dipg	NOUN
fnp-3341	106	7	samples	sample	NOUN
fnp-3341	106	8	(	(	PUNCT
fnp-3341	106	9	e	e	NOUN
fnp-3341	106	10	and	and	CCONJ
fnp-3341	106	11	f	f	PROPN
fnp-3341	106	12	)	)	PUNCT
fnp-3341	106	13	.	.	PUNCT
fnp-3341	107	1	(	(	PUNCT
fnp-3341	107	2	blue	blue	ADJ
fnp-3341	107	3	:	:	PUNCT
fnp-3341	107	4	nuclei	nucleus	NOUN
fnp-3341	107	5	;	;	PUNCT
fnp-3341	107	6	green	green	ADJ
fnp-3341	107	7	:	:	PUNCT
fnp-3341	107	8	astrocytes	astrocyte	NOUN
fnp-3341	107	9	;	;	PUNCT
fnp-3341	107	10	red	red	ADJ
fnp-3341	107	11	:	:	PUNCT
fnp-3341	107	12	p	p	X
fnp-3341	107	13	-	-	PUNCT
fnp-3341	107	14	gp	gp	NOUN
fnp-3341	107	15	or	or	CCONJ
fnp-3341	107	16	bcrp	bcrp	ADV
fnp-3341	107	17	;	;	PUNCT
fnp-3341	107	18	scale	scale	NOUN
fnp-3341	107	19	bar	bar	NOUN
fnp-3341	107	20	:	:	PUNCT
fnp-3341	107	21	5	5	NUM
fnp-3341	107	22	µm	µm	NOUN
fnp-3341	107	23	)	)	PUNCT
fnp-3341	107	24	vascular	vascular	ADJ
fnp-3341	107	25	density	density	NOUN
fnp-3341	107	26	vascular	vascular	ADJ
fnp-3341	107	27	density	density	NOUN
fnp-3341	107	28	per	per	ADP
fnp-3341	107	29	mm2	mm2	NOUN
fnp-3341	107	30	was	be	AUX
fnp-3341	107	31	measured	measure	VERB
fnp-3341	107	32	in	in	ADP
fnp-3341	107	33	non	non	ADJ
fnp-3341	107	34	-	-	ADJ
fnp-3341	107	35	necrotic	necrotic	ADJ
fnp-3341	107	36	biopsy	biopsy	NOUN
fnp-3341	107	37	and	and	CCONJ
fnp-3341	107	38	autopsy	autopsy	ADJ
fnp-3341	107	39	tissue	tissue	NOUN
fnp-3341	107	40	.	.	PUNCT
fnp-3341	108	1	it	it	PRON
fnp-3341	108	2	was	be	AUX
fnp-3341	108	3	significantly	significantly	ADV
fnp-3341	108	4	reduced	reduce	VERB
fnp-3341	108	5	in	in	ADP
fnp-3341	108	6	dipg	dipg	PROPN
fnp-3341	108	7	autopsy	autopsy	ADJ
fnp-3341	108	8	samples	sample	NOUN
fnp-3341	108	9	compared	compare	VERB
fnp-3341	108	10	to	to	ADP
fnp-3341	108	11	controls	control	NOUN
fnp-3341	108	12	(	(	PUNCT
fnp-3341	108	13	1.5±1.2	1.5±1.2	NUM
fnp-3341	108	14	/	/	SYM
fnp-3341	108	15	mm2	mm2	NOUN
fnp-3341	108	16	versus	versus	ADP
fnp-3341	108	17	17.5±9.5	17.5±9.5	NUM
fnp-3341	108	18	/	/	SYM
fnp-3341	108	19	mm2	mm2	PROPN
fnp-3341	108	20	,	,	PUNCT
fnp-3341	108	21	respectively	respectively	ADV
fnp-3341	108	22	;	;	PUNCT
fnp-3341	108	23	t113,890	t113,890	VERB
fnp-3341	108	24	=	=	SYM
fnp-3341	108	25	6.831	6.831	NUM
fnp-3341	108	26	,	,	PUNCT
fnp-3341	108	27	p	p	NOUN
fnp-3341	108	28	-	-	PUNCT
fnp-3341	108	29	value	value	NOUN
fnp-3341	108	30	<	<	NOUN
fnp-3341	108	31	0.001	0.001	NUM
fnp-3341	108	32	;	;	PUNCT
fnp-3341	108	33	figure	figure	NOUN
fnp-3341	108	34	6a	6a	NOUN
fnp-3341	108	35	)	)	PUNCT
fnp-3341	108	36	.	.	PUNCT
fnp-3341	109	1	notably	notably	ADV
fnp-3341	109	2	,	,	PUNCT
fnp-3341	109	3	the	the	DET
fnp-3341	109	4	density	density	NOUN
fnp-3341	109	5	of	of	ADP
fnp-3341	109	6	small	small	ADJ
fnp-3341	109	7	blood	blood	NOUN
fnp-3341	109	8	vessels	vessel	NOUN
fnp-3341	109	9	(	(	PUNCT
fnp-3341	109	10	<	<	X
fnp-3341	109	11	10	10	NUM
fnp-3341	109	12	µm	µm	NOUN
fnp-3341	109	13	)	)	PUNCT
fnp-3341	109	14	was	be	AUX
fnp-3341	109	15	significantly	significantly	ADV
fnp-3341	109	16	lower	low	ADJ
fnp-3341	109	17	in	in	ADP
fnp-3341	109	18	dipg	dipg	NOUN
fnp-3341	109	19	autopsy	autopsy	ADJ
fnp-3341	109	20	samples	sample	NOUN
fnp-3341	109	21	than	than	ADP
fnp-3341	109	22	in	in	ADP
fnp-3341	109	23	controls	control	NOUN
fnp-3341	109	24	(	(	PUNCT
fnp-3341	109	25	t180,609	t180,609	NOUN
fnp-3341	109	26	=	=	SYM
fnp-3341	109	27	-4.303	-4.303	X
fnp-3341	109	28	,	,	PUNCT
fnp-3341	109	29	p	p	NOUN
fnp-3341	109	30	-	-	PUNCT
fnp-3341	109	31	value	value	NOUN
fnp-3341	109	32	<	<	NOUN
fnp-3341	109	33	0.001	0.001	NUM
fnp-3341	109	34	)	)	PUNCT
fnp-3341	109	35	,	,	PUNCT
fnp-3341	109	36	whereas	whereas	SCONJ
fnp-3341	109	37	the	the	DET
fnp-3341	109	38	density	density	NOUN
fnp-3341	109	39	of	of	ADP
fnp-3341	109	40	large	large	ADJ
fnp-3341	109	41	blood	blood	NOUN
fnp-3341	109	42	vessels	vessel	NOUN
fnp-3341	109	43	(	(	PUNCT
fnp-3341	109	44	≥10	≥10	ADJ
fnp-3341	109	45	µm	µm	NOUN
fnp-3341	109	46	)	)	PUNCT
fnp-3341	109	47	did	do	AUX
fnp-3341	109	48	not	not	PART
fnp-3341	109	49	differ	differ	VERB
fnp-3341	109	50	between	between	ADP
fnp-3341	109	51	groups	group	NOUN
fnp-3341	109	52	(	(	PUNCT
fnp-3341	109	53	t597	t597	PROPN
fnp-3341	109	54	=	=	NOUN
fnp-3341	109	55	-0.835	-0.835	NOUN
fnp-3341	109	56	,	,	PUNCT
fnp-3341	109	57	p	p	NOUN
fnp-3341	109	58	-	-	PUNCT
fnp-3341	109	59	value	value	NOUN
fnp-3341	109	60	=	=	NOUN
fnp-3341	109	61	0.404	0.404	NUM
fnp-3341	109	62	)	)	PUNCT
fnp-3341	109	63	.	.	PUNCT
fnp-3341	110	1	most	most	ADJ
fnp-3341	110	2	blood	blood	NOUN
fnp-3341	110	3	vessels	vessel	NOUN
fnp-3341	110	4	in	in	ADP
fnp-3341	110	5	dipg	dipg	PROPN
fnp-3341	110	6	autopsy	autopsy	ADJ
fnp-3341	110	7	and	and	CCONJ
fnp-3341	110	8	control	control	NOUN
fnp-3341	110	9	samples	sample	NOUN
fnp-3341	110	10	had	have	VERB
fnp-3341	110	11	a	a	DET
fnp-3341	110	12	diameter	diameter	NOUN
fnp-3341	110	13	smaller	small	ADJ
fnp-3341	110	14	than	than	ADP
fnp-3341	110	15	10	10	NUM
fnp-3341	110	16	µm	µm	NOUN
fnp-3341	110	17	.	.	PUNCT
fnp-3341	111	1	the	the	DET
fnp-3341	111	2	median	median	ADJ
fnp-3341	111	3	vascular	vascular	ADJ
fnp-3341	111	4	diameter	diameter	NOUN
fnp-3341	111	5	was	be	AUX
fnp-3341	111	6	6.21	6.21	NUM
fnp-3341	111	7	µm	µm	NOUN
fnp-3341	111	8	in	in	ADP
fnp-3341	111	9	dipg	dipg	NOUN
fnp-3341	111	10	autopsy	autopsy	ADJ
fnp-3341	111	11	samples	sample	NOUN
fnp-3341	111	12	(	(	PUNCT
fnp-3341	111	13	range	range	NOUN
fnp-3341	111	14	2.25	2.25	NUM
fnp-3341	111	15	-	-	SYM
fnp-3341	111	16	94.85	94.85	NUM
fnp-3341	111	17	µm	µm	NOUN
fnp-3341	111	18	)	)	PUNCT
fnp-3341	111	19	,	,	PUNCT
fnp-3341	111	20	versus	versus	ADP
fnp-3341	111	21	6.26	6.26	NUM
fnp-3341	111	22	µm	µm	NOUN
fnp-3341	111	23	in	in	ADP
fnp-3341	111	24	controls	control	NOUN
fnp-3341	111	25	(	(	PUNCT
fnp-3341	111	26	range	range	NOUN
fnp-3341	111	27	1.17	1.17	NUM
fnp-3341	111	28	-	-	SYM
fnp-3341	111	29	264.77	264.77	NUM
fnp-3341	111	30	µm	µm	NOUN
fnp-3341	111	31	;	;	PUNCT
fnp-3341	111	32	figure	figure	NOUN
fnp-3341	111	33	6b	6b	NUM
fnp-3341	111	34	)	)	PUNCT
fnp-3341	111	35	.	.	PUNCT
fnp-3341	112	1	due	due	ADP
fnp-3341	112	2	to	to	ADP
fnp-3341	112	3	the	the	DET
fnp-3341	112	4	very	very	ADV
fnp-3341	112	5	small	small	ADJ
fnp-3341	112	6	size	size	NOUN
fnp-3341	112	7	of	of	ADP
fnp-3341	112	8	the	the	DET
fnp-3341	112	9	biopsy	biopsy	NOUN
fnp-3341	112	10	samples	sample	NOUN
fnp-3341	112	11	,	,	PUNCT
fnp-3341	112	12	it	it	PRON
fnp-3341	112	13	was	be	AUX
fnp-3341	112	14	not	not	PART
fnp-3341	112	15	possible	possible	ADJ
fnp-3341	112	16	to	to	PART
fnp-3341	112	17	statistically	statistically	ADV
fnp-3341	112	18	analyze	analyze	VERB
fnp-3341	112	19	the	the	DET
fnp-3341	112	20	vascular	vascular	ADJ
fnp-3341	112	21	density	density	NOUN
fnp-3341	112	22	and	and	CCONJ
fnp-3341	112	23	diameter	diameter	NOUN
fnp-3341	112	24	in	in	ADP
fnp-3341	112	25	these	these	DET
fnp-3341	112	26	tissue	tissue	NOUN
fnp-3341	112	27	samples	sample	NOUN
fnp-3341	112	28	.	.	PUNCT
fnp-3341	113	1	visual	visual	ADJ
fnp-3341	113	2	inspection	inspection	NOUN
fnp-3341	113	3	of	of	ADP
fnp-3341	113	4	three	three	NUM
fnp-3341	113	5	patients	patient	NOUN
fnp-3341	113	6	,	,	PUNCT
fnp-3341	113	7	however	however	ADV
fnp-3341	113	8	,	,	PUNCT
fnp-3341	113	9	showed	show	VERB
fnp-3341	113	10	a	a	DET
fnp-3341	113	11	mean	mean	ADJ
fnp-3341	113	12	vascular	vascular	ADJ
fnp-3341	113	13	density	density	NOUN
fnp-3341	113	14	of	of	ADP
fnp-3341	113	15	7.5	7.5	NUM
fnp-3341	113	16	vessels	vessel	NOUN
fnp-3341	113	17	per	per	ADP
fnp-3341	113	18	mm2	mm2	NOUN
fnp-3341	113	19	,	,	PUNCT
fnp-3341	113	20	and	and	CCONJ
fnp-3341	113	21	a	a	DET
fnp-3341	113	22	median	median	ADJ
fnp-3341	113	23	vascular	vascular	ADJ
fnp-3341	113	24	diameter	diameter	NOUN
fnp-3341	113	25	of	of	ADP
fnp-3341	113	26	8.23	8.23	NUM
fnp-3341	113	27	µm	µm	NOUN
fnp-3341	113	28	(	(	PUNCT
fnp-3341	113	29	data	datum	NOUN
fnp-3341	113	30	not	not	PART
fnp-3341	113	31	shown	show	VERB
fnp-3341	113	32	)	)	PUNCT
fnp-3341	113	33	.	.	PUNCT
fnp-3341	114	1	figure	figure	VERB
fnp-3341	114	2	6	6	NUM
fnp-3341	114	3	:	:	PUNCT
fnp-3341	114	4	vascular	vascular	ADJ
fnp-3341	114	5	density	density	NOUN
fnp-3341	114	6	and	and	CCONJ
fnp-3341	114	7	diameter	diameter	NOUN
fnp-3341	114	8	in	in	ADP
fnp-3341	114	9	dipg	dipg	PROPN
fnp-3341	114	10	post	post	ADJ
fnp-3341	114	11	-	-	ADJ
fnp-3341	114	12	mortem	mortem	ADJ
fnp-3341	114	13	autopsy	autopsy	ADJ
fnp-3341	114	14	and	and	CCONJ
fnp-3341	114	15	healthy	healthy	ADJ
fnp-3341	114	16	control	control	NOUN
fnp-3341	114	17	samples	sample	NOUN
fnp-3341	114	18	.	.	PUNCT
fnp-3341	115	1	a	a	DET
fnp-3341	115	2	:	:	PUNCT
fnp-3341	115	3	vascular	vascular	ADJ
fnp-3341	115	4	density	density	NOUN
fnp-3341	115	5	in	in	ADP
fnp-3341	115	6	dipg	dipg	PROPN
fnp-3341	115	7	post	post	ADJ
fnp-3341	115	8	-	-	ADJ
fnp-3341	115	9	mortem	mortem	ADJ
fnp-3341	115	10	autopsy	autopsy	ADJ
fnp-3341	115	11	samples	sample	NOUN
fnp-3341	115	12	and	and	CCONJ
fnp-3341	115	13	healthy	healthy	ADJ
fnp-3341	115	14	control	control	NOUN
fnp-3341	115	15	samples	sample	NOUN
fnp-3341	115	16	.	.	PUNCT
fnp-3341	116	1	mean	mean	VERB
fnp-3341	116	2	vascular	vascular	ADJ
fnp-3341	116	3	density	density	NOUN
fnp-3341	116	4	was	be	AUX
fnp-3341	116	5	1.5±1.2	1.5±1.2	NUM
fnp-3341	116	6	/	/	SYM
fnp-3341	116	7	mm2	mm2	NOUN
fnp-3341	116	8	in	in	ADP
fnp-3341	116	9	dipg	dipg	NOUN
fnp-3341	116	10	versus	versus	ADP
fnp-3341	116	11	17.5±9.5	17.5±9.5	NUM
fnp-3341	116	12	/	/	SYM
fnp-3341	116	13	mm2	mm2	NOUN
fnp-3341	116	14	in	in	ADP
fnp-3341	116	15	controls	control	NOUN
fnp-3341	116	16	(	(	PUNCT
fnp-3341	116	17	red	red	ADJ
fnp-3341	116	18	line	line	NOUN
fnp-3341	116	19	)	)	PUNCT
fnp-3341	116	20	.	.	PUNCT
fnp-3341	117	1	b	b	X
fnp-3341	117	2	:	:	PUNCT
fnp-3341	117	3	vascular	vascular	ADJ
fnp-3341	117	4	size	size	NOUN
fnp-3341	117	5	distribution	distribution	NOUN
fnp-3341	117	6	in	in	ADP
fnp-3341	117	7	dipg	dipg	PROPN
fnp-3341	117	8	post	post	ADJ
fnp-3341	117	9	-	-	ADJ
fnp-3341	117	10	mortem	mortem	ADJ
fnp-3341	117	11	samples	sample	NOUN
fnp-3341	117	12	and	and	CCONJ
fnp-3341	117	13	healthy	healthy	ADJ
fnp-3341	117	14	control	control	NOUN
fnp-3341	117	15	samples	sample	NOUN
fnp-3341	117	16	.	.	PUNCT
fnp-3341	118	1	discussion	discussion	NOUN
fnp-3341	118	2	little	little	ADJ
fnp-3341	118	3	research	research	NOUN
fnp-3341	118	4	has	have	AUX
fnp-3341	118	5	been	be	AUX
fnp-3341	118	6	done	do	VERB
fnp-3341	118	7	to	to	PART
fnp-3341	118	8	identify	identify	VERB
fnp-3341	118	9	the	the	DET
fnp-3341	118	10	nvu	nvu	NOUN
fnp-3341	118	11	in	in	ADP
fnp-3341	118	12	dipg	dipg	NOUN
fnp-3341	118	13	,	,	PUNCT
fnp-3341	118	14	while	while	SCONJ
fnp-3341	118	15	it	it	PRON
fnp-3341	118	16	is	be	AUX
fnp-3341	118	17	hypothesized	hypothesize	VERB
fnp-3341	118	18	that	that	SCONJ
fnp-3341	118	19	treatment	treatment	NOUN
fnp-3341	118	20	failure	failure	NOUN
fnp-3341	118	21	is	be	AUX
fnp-3341	118	22	caused	cause	VERB
fnp-3341	118	23	by	by	ADP
fnp-3341	118	24	an	an	DET
fnp-3341	118	25	intact	intact	ADJ
fnp-3341	118	26	bbb	bbb	NOUN
fnp-3341	118	27	.	.	PUNCT
fnp-3341	119	1	as	as	SCONJ
fnp-3341	119	2	summarized	summarize	VERB
fnp-3341	119	3	by	by	ADP
fnp-3341	119	4	figure	figure	NOUN
fnp-3341	119	5	7	7	NUM
fnp-3341	119	6	,	,	PUNCT
fnp-3341	119	7	our	our	PRON
fnp-3341	119	8	study	study	NOUN
fnp-3341	119	9	demonstrates	demonstrate	VERB
fnp-3341	119	10	structural	structural	ADJ
fnp-3341	119	11	changes	change	NOUN
fnp-3341	119	12	in	in	ADP
fnp-3341	119	13	the	the	DET
fnp-3341	119	14	nvu	nvu	NOUN
fnp-3341	119	15	of	of	ADP
fnp-3341	119	16	dipg	dipg	NOUN
fnp-3341	119	17	patients	patient	NOUN
fnp-3341	119	18	that	that	PRON
fnp-3341	119	19	are	be	AUX
fnp-3341	119	20	already	already	ADV
fnp-3341	119	21	present	present	ADJ
fnp-3341	119	22	at	at	ADP
fnp-3341	119	23	diagnosis	diagnosis	NOUN
fnp-3341	119	24	,	,	PUNCT
fnp-3341	119	25	suggesting	suggest	VERB
fnp-3341	119	26	these	these	PRON
fnp-3341	119	27	to	to	PART
fnp-3341	119	28	be	be	AUX
fnp-3341	119	29	tumor	tumor	NOUN
fnp-3341	119	30	-	-	PUNCT
fnp-3341	119	31	related	relate	VERB
fnp-3341	119	32	and	and	CCONJ
fnp-3341	119	33	not	not	PART
fnp-3341	119	34	only	only	ADV
fnp-3341	119	35	due	due	ADJ
fnp-3341	119	36	to	to	ADP
fnp-3341	119	37	treatment	treatment	NOUN
fnp-3341	119	38	.	.	PUNCT
fnp-3341	120	1	all	all	DET
fnp-3341	120	2	studied	study	VERB
fnp-3341	120	3	dipg	dipg	NOUN
fnp-3341	120	4	patients	patient	NOUN
fnp-3341	120	5	harbored	harbor	VERB
fnp-3341	120	6	a	a	DET
fnp-3341	120	7	h3k27	h3k27	NOUN
fnp-3341	120	8	m	m	NOUN
fnp-3341	120	9	mutation	mutation	NOUN
fnp-3341	120	10	,	,	PUNCT
fnp-3341	120	11	thus	thus	ADV
fnp-3341	120	12	fulfilling	fulfil	VERB
fnp-3341	120	13	the	the	DET
fnp-3341	120	14	diagnosis	diagnosis	NOUN
fnp-3341	120	15	of	of	ADP
fnp-3341	120	16	dmg	dmg	PROPN
fnp-3341	120	17	h3k27	h3k27	NOUN
fnp-3341	120	18	m	m	VERB
fnp-3341	120	19	according	accord	VERB
fnp-3341	120	20	to	to	ADP
fnp-3341	120	21	the	the	DET
fnp-3341	120	22	revised	revise	VERB
fnp-3341	120	23	who	who	PRON
fnp-3341	120	24	classification	classification	VERB
fnp-3341	120	25	8	8	NUM
fnp-3341	120	26	.	.	PUNCT
fnp-3341	120	27	up	up	ADP
fnp-3341	120	28	to	to	PART
fnp-3341	120	29	85	85	NUM
fnp-3341	120	30	%	%	NOUN
fnp-3341	120	31	of	of	ADP
fnp-3341	120	32	dipg	dipg	NOUN
fnp-3341	120	33	patients	patient	NOUN
fnp-3341	120	34	harbor	harbor	VERB
fnp-3341	120	35	this	this	DET
fnp-3341	120	36	mutation	mutation	NOUN
fnp-3341	120	37	21,22	21,22	NOUN
fnp-3341	120	38	.	.	PUNCT
fnp-3341	121	1	since	since	SCONJ
fnp-3341	121	2	three	three	NUM
fnp-3341	121	3	out	out	ADP
fnp-3341	121	4	of	of	ADP
fnp-3341	121	5	six	six	NUM
fnp-3341	121	6	dipg	dipg	NOUN
fnp-3341	121	7	autopsy	autopsy	ADJ
fnp-3341	121	8	patients	patient	NOUN
fnp-3341	121	9	were	be	AUX
fnp-3341	121	10	long	long	ADJ
fnp-3341	121	11	-	-	PUNCT
fnp-3341	121	12	term	term	NOUN
fnp-3341	121	13	survivors	survivor	NOUN
fnp-3341	121	14	,	,	PUNCT
fnp-3341	121	15	the	the	DET
fnp-3341	121	16	median	median	ADJ
fnp-3341	121	17	overall	overall	ADJ
fnp-3341	121	18	survival	survival	NOUN
fnp-3341	121	19	of	of	ADP
fnp-3341	121	20	the	the	DET
fnp-3341	121	21	patients	patient	NOUN
fnp-3341	121	22	in	in	ADP
fnp-3341	121	23	this	this	DET
fnp-3341	121	24	group	group	NOUN
fnp-3341	121	25	was	be	AUX
fnp-3341	121	26	longer	long	ADJ
fnp-3341	121	27	than	than	SCONJ
fnp-3341	121	28	known	know	VERB
fnp-3341	121	29	from	from	ADP
fnp-3341	121	30	literature	literature	NOUN
fnp-3341	121	31	,	,	PUNCT
fnp-3341	121	32	19.5	19.5	NUM
fnp-3341	121	33	months	month	NOUN
fnp-3341	121	34	versus	versus	ADP
fnp-3341	121	35	11	11	NUM
fnp-3341	121	36	months	month	NOUN
fnp-3341	121	37	,	,	PUNCT
fnp-3341	121	38	respectively	respectively	ADV
fnp-3341	121	39	7	7	NUM
fnp-3341	121	40	.	.	PUNCT
fnp-3341	122	1	whether	whether	SCONJ
fnp-3341	122	2	neuropathological	neuropathological	ADJ
fnp-3341	122	3	grading	grading	NOUN
fnp-3341	122	4	(	(	PUNCT
fnp-3341	122	5	who	who	PRON
fnp-3341	122	6	ii	ii	NOUN
fnp-3341	122	7	-	-	PUNCT
fnp-3341	122	8	iv	iv	NUM
fnp-3341	122	9	)	)	PUNCT
fnp-3341	122	10	,	,	PUNCT
fnp-3341	122	11	tumor	tumor	NOUN
fnp-3341	122	12	location	location	NOUN
fnp-3341	122	13	or	or	CCONJ
fnp-3341	122	14	the	the	DET
fnp-3341	122	15	presence	presence	NOUN
fnp-3341	122	16	of	of	ADP
fnp-3341	122	17	a	a	DET
fnp-3341	122	18	h3k27	h3k27	PROPN
fnp-3341	122	19	m	m	NOUN
fnp-3341	122	20	mutation	mutation	NOUN
fnp-3341	122	21	have	have	VERB
fnp-3341	122	22	an	an	DET
fnp-3341	122	23	impact	impact	NOUN
fnp-3341	122	24	on	on	ADP
fnp-3341	122	25	survival	survival	NOUN
fnp-3341	122	26	is	be	AUX
fnp-3341	122	27	still	still	ADV
fnp-3341	122	28	not	not	PART
fnp-3341	122	29	clear	clear	ADJ
fnp-3341	122	30	22	22	NUM
fnp-3341	122	31	-	-	SYM
fnp-3341	122	32	24	24	NUM
fnp-3341	122	33	.	.	PUNCT
fnp-3341	122	34	figure	figure	VERB
fnp-3341	122	35	7	7	NUM
fnp-3341	122	36	:	:	PUNCT
fnp-3341	122	37	graphical	graphical	ADJ
fnp-3341	122	38	overview	overview	NOUN
fnp-3341	122	39	of	of	ADP
fnp-3341	122	40	the	the	DET
fnp-3341	122	41	structural	structural	ADJ
fnp-3341	122	42	capillary	capillary	ADJ
fnp-3341	122	43	changes	change	NOUN
fnp-3341	122	44	observed	observe	VERB
fnp-3341	122	45	in	in	ADP
fnp-3341	122	46	dipg	dipg	PROPN
fnp-3341	122	47	pre	pre	ADJ
fnp-3341	122	48	-	-	ADJ
fnp-3341	122	49	treatment	treatment	ADJ
fnp-3341	122	50	biopsy	biopsy	NOUN
fnp-3341	122	51	and	and	CCONJ
fnp-3341	122	52	post	post	ADJ
fnp-3341	122	53	-	-	ADJ
fnp-3341	122	54	mortem	mortem	ADJ
fnp-3341	122	55	autopsy	autopsy	ADJ
fnp-3341	122	56	samples	sample	NOUN
fnp-3341	122	57	:	:	PUNCT
fnp-3341	122	58	lower	low	ADJ
fnp-3341	122	59	expression	expression	NOUN
fnp-3341	122	60	of	of	ADP
fnp-3341	122	61	tight	tight	ADJ
fnp-3341	122	62	junction	junction	NOUN
fnp-3341	122	63	proteins	protein	NOUN
fnp-3341	122	64	claudin-5	claudin-5	NUM
fnp-3341	122	65	and	and	CCONJ
fnp-3341	122	66	zo-1	zo-1	NUM
fnp-3341	122	67	,	,	PUNCT
fnp-3341	122	68	basement	basement	NOUN
fnp-3341	122	69	membrane	membrane	NOUN
fnp-3341	122	70	component	component	NOUN
fnp-3341	122	71	laminin	laminin	NOUN
fnp-3341	122	72	,	,	PUNCT
fnp-3341	122	73	pericyte	pericyte	NOUN
fnp-3341	122	74	marker	marker	NOUN
fnp-3341	122	75	pdgfr	pdgfr	NOUN
fnp-3341	122	76	-	-	PUNCT
fnp-3341	122	77	β	β	NOUN
fnp-3341	122	78	and	and	CCONJ
fnp-3341	122	79	efflux	efflux	VERB
fnp-3341	122	80	transporter	transporter	NOUN
fnp-3341	122	81	p	p	NOUN
fnp-3341	122	82	-	-	NOUN
fnp-3341	122	83	gp	gp	NOUN
fnp-3341	122	84	in	in	ADP
fnp-3341	122	85	dipg	dipg	PROPN
fnp-3341	122	86	biopsy	biopsy	PROPN
fnp-3341	122	87	and	and	CCONJ
fnp-3341	122	88	autopsy	autopsy	ADJ
fnp-3341	122	89	samples	sample	NOUN
fnp-3341	122	90	;	;	PUNCT
fnp-3341	122	91	unchanged	unchanged	ADJ
fnp-3341	122	92	expression	expression	NOUN
fnp-3341	122	93	of	of	ADP
fnp-3341	122	94	efflux	efflux	NOUN
fnp-3341	122	95	transporter	transporter	NOUN
fnp-3341	122	96	bcrp-1	bcrp-1	PROPN
fnp-3341	122	97	in	in	ADP
fnp-3341	122	98	dipg	dipg	PROPN
fnp-3341	122	99	biopsy	biopsy	NOUN
fnp-3341	122	100	and	and	CCONJ
fnp-3341	122	101	autopsy	autopsy	ADJ
fnp-3341	122	102	samples	sample	NOUN
fnp-3341	122	103	.	.	PUNCT
fnp-3341	123	1	the	the	DET
fnp-3341	123	2	barrier	barrier	NOUN
fnp-3341	123	3	properties	property	NOUN
fnp-3341	123	4	of	of	ADP
fnp-3341	123	5	the	the	DET
fnp-3341	123	6	nvu	nvu	NOUN
fnp-3341	123	7	strongly	strongly	ADV
fnp-3341	123	8	depend	depend	VERB
fnp-3341	123	9	on	on	ADP
fnp-3341	123	10	the	the	DET
fnp-3341	123	11	complex	complex	ADJ
fnp-3341	123	12	interaction	interaction	NOUN
fnp-3341	123	13	between	between	ADP
fnp-3341	123	14	endothelial	endothelial	ADJ
fnp-3341	123	15	cells	cell	NOUN
fnp-3341	123	16	and	and	CCONJ
fnp-3341	123	17	their	their	PRON
fnp-3341	123	18	tight	tight	ADJ
fnp-3341	123	19	junctions	junction	NOUN
fnp-3341	123	20	,	,	PUNCT
fnp-3341	123	21	pericytes	pericyte	NOUN
fnp-3341	123	22	,	,	PUNCT
fnp-3341	123	23	basement	basement	NOUN
fnp-3341	123	24	membranes	membrane	NOUN
fnp-3341	123	25	and	and	CCONJ
fnp-3341	123	26	astrocytes	astrocyte	NOUN
fnp-3341	123	27	.	.	PUNCT
fnp-3341	124	1	in	in	ADP
fnp-3341	124	2	physiological	physiological	ADJ
fnp-3341	124	3	conditions	condition	NOUN
fnp-3341	124	4	,	,	PUNCT
fnp-3341	124	5	tight	tight	ADJ
fnp-3341	124	6	junctions	junction	NOUN
fnp-3341	124	7	are	be	AUX
fnp-3341	124	8	formed	form	VERB
fnp-3341	124	9	by	by	ADP
fnp-3341	124	10	inter	inter	ADJ
fnp-3341	124	11	-	-	ADJ
fnp-3341	124	12	endothelial	endothelial	ADJ
fnp-3341	124	13	connections	connection	NOUN
fnp-3341	124	14	between	between	ADP
fnp-3341	124	15	transmembrane	transmembrane	ADJ
fnp-3341	124	16	proteins	protein	NOUN
fnp-3341	124	17	of	of	ADP
fnp-3341	124	18	the	the	DET
fnp-3341	124	19	claudin	claudin	NOUN
fnp-3341	124	20	-	-	PUNCT
fnp-3341	124	21	family	family	NOUN
fnp-3341	124	22	(	(	PUNCT
fnp-3341	124	23	claudin-1	claudin-1	PROPN
fnp-3341	124	24	,	,	PUNCT
fnp-3341	124	25	3	3	NUM
fnp-3341	124	26	,	,	PUNCT
fnp-3341	124	27	5	5	NUM
fnp-3341	124	28	,	,	PUNCT
fnp-3341	124	29	and	and	CCONJ
fnp-3341	124	30	12	12	NUM
fnp-3341	124	31	)	)	PUNCT
fnp-3341	124	32	,	,	PUNCT
fnp-3341	124	33	which	which	PRON
fnp-3341	124	34	regulate	regulate	VERB
fnp-3341	124	35	the	the	DET
fnp-3341	124	36	function	function	NOUN
fnp-3341	124	37	of	of	ADP
fnp-3341	124	38	these	these	DET
fnp-3341	124	39	tight	tight	ADJ
fnp-3341	124	40	junctions25,26	junctions25,26	PROPN
fnp-3341	124	41	.	.	PUNCT
fnp-3341	124	42	claudins	claudin	NOUN
fnp-3341	124	43	are	be	AUX
fnp-3341	124	44	anchored	anchor	VERB
fnp-3341	124	45	into	into	ADP
fnp-3341	124	46	the	the	DET
fnp-3341	124	47	endothelial	endothelial	ADJ
fnp-3341	124	48	cells	cell	NOUN
fnp-3341	124	49	by	by	ADP
fnp-3341	124	50	proteins	protein	NOUN
fnp-3341	124	51	from	from	ADP
fnp-3341	124	52	the	the	DET
fnp-3341	124	53	zonula	zonula	NOUN
fnp-3341	124	54	occludens	occludens	PROPN
fnp-3341	124	55	-	-	PUNCT
fnp-3341	124	56	family	family	NOUN
fnp-3341	124	57	(	(	PUNCT
fnp-3341	124	58	zo-1	zo-1	NUM
fnp-3341	124	59	,	,	PUNCT
fnp-3341	124	60	2	2	NUM
fnp-3341	124	61	,	,	PUNCT
fnp-3341	124	62	and	and	CCONJ
fnp-3341	124	63	3	3	X
fnp-3341	124	64	)	)	PUNCT
fnp-3341	124	65	that	that	PRON
fnp-3341	124	66	regulate	regulate	VERB
fnp-3341	124	67	adherens	adheren	NOUN
fnp-3341	124	68	junctions	junction	NOUN
fnp-3341	124	69	and	and	CCONJ
fnp-3341	124	70	influence	influence	NOUN
fnp-3341	124	71	cytoskeletal	cytoskeletal	ADJ
fnp-3341	124	72	organization	organization	NOUN
fnp-3341	124	73	,	,	PUNCT
fnp-3341	124	74	angiogenic	angiogenic	ADJ
fnp-3341	124	75	potential	potential	ADJ
fnp-3341	124	76	and	and	CCONJ
fnp-3341	124	77	cell	cell	NOUN
fnp-3341	124	78	migration	migration	NOUN
fnp-3341	124	79	27	27	NUM
fnp-3341	124	80	.	.	PUNCT
fnp-3341	125	1	moreover	moreover	ADV
fnp-3341	125	2	,	,	PUNCT
fnp-3341	125	3	zo-1	zo-1	PUNCT
fnp-3341	125	4	is	be	AUX
fnp-3341	125	5	responsible	responsible	ADJ
fnp-3341	125	6	for	for	ADP
fnp-3341	125	7	the	the	DET
fnp-3341	125	8	spatial	spatial	ADJ
fnp-3341	125	9	organization	organization	NOUN
fnp-3341	125	10	of	of	ADP
fnp-3341	125	11	claudin-5	claudin-5	NUM
fnp-3341	125	12	by	by	ADP
fnp-3341	125	13	linking	link	VERB
fnp-3341	125	14	it	it	PRON
fnp-3341	125	15	to	to	ADP
fnp-3341	125	16	the	the	DET
fnp-3341	125	17	actin	actin	NOUN
fnp-3341	125	18	cytoskeleton	cytoskeleton	PROPN
fnp-3341	125	19	25	25	NUM
fnp-3341	125	20	.	.	PUNCT
fnp-3341	126	1	downregulation	downregulation	NOUN
fnp-3341	126	2	of	of	ADP
fnp-3341	126	3	zo-1	zo-1	NUM
fnp-3341	126	4	can	can	AUX
fnp-3341	126	5	lead	lead	VERB
fnp-3341	126	6	to	to	ADP
fnp-3341	126	7	tight	tight	ADJ
fnp-3341	126	8	junction	junction	NOUN
fnp-3341	126	9	disruption	disruption	NOUN
fnp-3341	126	10	and	and	CCONJ
fnp-3341	126	11	a	a	DET
fnp-3341	126	12	larger	large	ADJ
fnp-3341	126	13	intercellular	intercellular	ADJ
fnp-3341	126	14	distance	distance	NOUN
fnp-3341	126	15	between	between	ADP
fnp-3341	126	16	endothelial	endothelial	ADJ
fnp-3341	126	17	cells	cell	NOUN
fnp-3341	126	18	and	and	CCONJ
fnp-3341	126	19	thus	thus	ADV
fnp-3341	126	20	pathologically	pathologically	ADV
fnp-3341	126	21	increased	increase	VERB
fnp-3341	126	22	paracellular	paracellular	ADJ
fnp-3341	126	23	transport	transport	NOUN
fnp-3341	126	24	27	27	NUM
fnp-3341	126	25	.	.	PUNCT
fnp-3341	127	1	claudin-5	claudin-5	PRON
fnp-3341	127	2	is	be	AUX
fnp-3341	127	3	most	most	ADV
fnp-3341	127	4	abundant	abundant	ADJ
fnp-3341	127	5	in	in	ADP
fnp-3341	127	6	brain	brain	NOUN
fnp-3341	127	7	vessels	vessel	NOUN
fnp-3341	127	8	(	(	PUNCT
fnp-3341	127	9	600	600	NUM
fnp-3341	127	10	-	-	PUNCT
fnp-3341	127	11	times	time	NOUN
fnp-3341	127	12	higher	high	ADJ
fnp-3341	127	13	expression	expression	NOUN
fnp-3341	127	14	than	than	ADP
fnp-3341	127	15	other	other	ADJ
fnp-3341	127	16	claudins	claudin	NOUN
fnp-3341	127	17	)	)	PUNCT
fnp-3341	127	18	,	,	PUNCT
fnp-3341	127	19	where	where	SCONJ
fnp-3341	127	20	it	it	PRON
fnp-3341	127	21	has	have	VERB
fnp-3341	127	22	a	a	DET
fnp-3341	127	23	heterogeneous	heterogeneous	ADJ
fnp-3341	127	24	distribution	distribution	NOUN
fnp-3341	127	25	26	26	NUM
fnp-3341	127	26	.	.	PUNCT
fnp-3341	128	1	the	the	DET
fnp-3341	128	2	highest	high	ADJ
fnp-3341	128	3	claudin-5	claudin-5	NUM
fnp-3341	128	4	expression	expression	NOUN
fnp-3341	128	5	is	be	AUX
fnp-3341	128	6	seen	see	VERB
fnp-3341	128	7	in	in	ADP
fnp-3341	128	8	capillaries	capillary	NOUN
fnp-3341	128	9	and	and	CCONJ
fnp-3341	128	10	small	small	ADJ
fnp-3341	128	11	post	post	ADJ
fnp-3341	128	12	-	-	ADJ
fnp-3341	128	13	capillary	capillary	ADJ
fnp-3341	128	14	venules	venule	NOUN
fnp-3341	128	15	25,28	25,28	NUM
fnp-3341	128	16	.	.	PUNCT
fnp-3341	129	1	in	in	ADP
fnp-3341	129	2	a	a	DET
fnp-3341	129	3	claudin-5	claudin-5	NUM
fnp-3341	129	4	knockout	knockout	NOUN
fnp-3341	129	5	mouse	mouse	NOUN
fnp-3341	129	6	model	model	NOUN
fnp-3341	129	7	,	,	PUNCT
fnp-3341	129	8	an	an	DET
fnp-3341	129	9	increased	increase	VERB
fnp-3341	129	10	leakage	leakage	NOUN
fnp-3341	129	11	of	of	ADP
fnp-3341	129	12	molecules	molecule	NOUN
fnp-3341	129	13	up	up	ADP
fnp-3341	129	14	to	to	PART
fnp-3341	129	15	800	800	NUM
fnp-3341	129	16	da	da	NOUN
fnp-3341	129	17	was	be	AUX
fnp-3341	129	18	observed	observe	VERB
fnp-3341	129	19	29	29	NUM
fnp-3341	129	20	,	,	PUNCT
fnp-3341	129	21	whereas	whereas	SCONJ
fnp-3341	129	22	the	the	DET
fnp-3341	129	23	permeability	permeability	NOUN
fnp-3341	129	24	of	of	ADP
fnp-3341	129	25	normal	normal	ADJ
fnp-3341	129	26	bbb	bbb	NOUN
fnp-3341	129	27	only	only	ADV
fnp-3341	129	28	allows	allow	VERB
fnp-3341	129	29	passage	passage	NOUN
fnp-3341	129	30	of	of	ADP
fnp-3341	129	31	molecules	molecule	NOUN
fnp-3341	129	32	up	up	ADP
fnp-3341	129	33	to	to	PART
fnp-3341	129	34	500	500	NUM
fnp-3341	129	35	da	da	NOUN
fnp-3341	129	36	30,31	30,31	NUM
fnp-3341	129	37	.	.	PUNCT
fnp-3341	130	1	when	when	SCONJ
fnp-3341	130	2	additional	additional	ADJ
fnp-3341	130	3	tight	tight	ADJ
fnp-3341	130	4	junction	junction	NOUN
fnp-3341	130	5	proteins	protein	NOUN
fnp-3341	130	6	are	be	AUX
fnp-3341	130	7	downregulated	downregulate	VERB
fnp-3341	130	8	,	,	PUNCT
fnp-3341	130	9	a	a	DET
fnp-3341	130	10	size	size	NOUN
fnp-3341	130	11	-	-	PUNCT
fnp-3341	130	12	dependent	dependent	ADJ
fnp-3341	130	13	increase	increase	NOUN
fnp-3341	130	14	in	in	ADP
fnp-3341	130	15	paracellular	paracellular	ADJ
fnp-3341	130	16	transport	transport	NOUN
fnp-3341	130	17	is	be	AUX
fnp-3341	130	18	seen	see	VERB
fnp-3341	130	19	of	of	ADP
fnp-3341	130	20	molecules	molecule	NOUN
fnp-3341	130	21	with	with	ADP
fnp-3341	130	22	a	a	DET
fnp-3341	130	23	size	size	NOUN
fnp-3341	130	24	up	up	ADP
fnp-3341	130	25	to	to	PART
fnp-3341	130	26	10,000	10,000	NUM
fnp-3341	130	27	da	da	NUM
fnp-3341	130	28	29,32	29,32	PROPN
fnp-3341	130	29	.	.	PUNCT
fnp-3341	131	1	in	in	ADP
fnp-3341	131	2	our	our	PRON
fnp-3341	131	3	study	study	NOUN
fnp-3341	131	4	,	,	PUNCT
fnp-3341	131	5	a	a	DET
fnp-3341	131	6	reduced	reduced	ADJ
fnp-3341	131	7	expression	expression	NOUN
fnp-3341	131	8	of	of	ADP
fnp-3341	131	9	claudin-5	claudin-5	PRON
fnp-3341	131	10	and	and	CCONJ
fnp-3341	131	11	zo-1	zo-1	NUM
fnp-3341	131	12	was	be	AUX
fnp-3341	131	13	observed	observe	VERB
fnp-3341	131	14	in	in	ADP
fnp-3341	131	15	dipg	dipg	NOUN
fnp-3341	131	16	patients	patient	NOUN
fnp-3341	131	17	both	both	DET
fnp-3341	131	18	pre	pre	ADJ
fnp-3341	131	19	-	-	NOUN
fnp-3341	131	20	treatment	treatment	NOUN
fnp-3341	131	21	and	and	CCONJ
fnp-3341	131	22	post	post	NOUN
fnp-3341	131	23	-	-	ADJ
fnp-3341	131	24	mortem	mortem	ADJ
fnp-3341	131	25	,	,	PUNCT
fnp-3341	131	26	indicating	indicate	VERB
fnp-3341	131	27	a	a	DET
fnp-3341	131	28	barrier	barrier	NOUN
fnp-3341	131	29	defect	defect	NOUN
fnp-3341	131	30	,	,	PUNCT
fnp-3341	131	31	and	and	CCONJ
fnp-3341	131	32	increasing	increase	VERB
fnp-3341	131	33	paracellular	paracellular	ADJ
fnp-3341	131	34	transport	transport	NOUN
fnp-3341	131	35	across	across	ADP
fnp-3341	131	36	the	the	DET
fnp-3341	131	37	bbb	bbb	PROPN
fnp-3341	131	38	27	27	NUM
fnp-3341	131	39	.	.	PUNCT
fnp-3341	132	1	nevertheless	nevertheless	ADV
fnp-3341	132	2	,	,	PUNCT
fnp-3341	132	3	there	there	PRON
fnp-3341	132	4	are	be	VERB
fnp-3341	132	5	more	more	ADV
fnp-3341	132	6	tight	tight	ADJ
fnp-3341	132	7	junction	junction	NOUN
fnp-3341	132	8	proteins	protein	NOUN
fnp-3341	132	9	of	of	ADP
fnp-3341	132	10	the	the	DET
fnp-3341	132	11	zonula	zonula	NOUN
fnp-3341	132	12	occludens	occluden	NOUN
fnp-3341	132	13	and	and	CCONJ
fnp-3341	132	14	claudin	claudin	NOUN
fnp-3341	132	15	-	-	PUNCT
fnp-3341	132	16	family	family	NOUN
fnp-3341	132	17	expressed	express	VERB
fnp-3341	132	18	by	by	ADP
fnp-3341	132	19	brain	brain	NOUN
fnp-3341	132	20	endothelial	endothelial	ADJ
fnp-3341	132	21	cells	cell	NOUN
fnp-3341	132	22	.	.	PUNCT
fnp-3341	133	1	whether	whether	SCONJ
fnp-3341	133	2	possible	possible	ADJ
fnp-3341	133	3	downregulation	downregulation	NOUN
fnp-3341	133	4	of	of	ADP
fnp-3341	133	5	claudin-5	claudin-5	PRON
fnp-3341	133	6	and	and	CCONJ
fnp-3341	133	7	zo-1	zo-1	NUM
fnp-3341	133	8	is	be	AUX
fnp-3341	133	9	compensated	compensate	VERB
fnp-3341	133	10	by	by	ADP
fnp-3341	133	11	overexpression	overexpression	NOUN
fnp-3341	133	12	of	of	ADP
fnp-3341	133	13	other	other	ADJ
fnp-3341	133	14	tight	tight	ADJ
fnp-3341	133	15	junction	junction	NOUN
fnp-3341	133	16	proteins	protein	NOUN
fnp-3341	133	17	remains	remain	VERB
fnp-3341	133	18	unknown	unknown	ADJ
fnp-3341	133	19	.	.	PUNCT
fnp-3341	134	1	endothelial	endothelial	ADJ
fnp-3341	134	2	cells	cell	NOUN
fnp-3341	134	3	are	be	AUX
fnp-3341	134	4	surrounded	surround	VERB
fnp-3341	134	5	by	by	ADP
fnp-3341	134	6	a	a	DET
fnp-3341	134	7	basement	basement	NOUN
fnp-3341	134	8	membrane	membrane	NOUN
fnp-3341	134	9	that	that	PRON
fnp-3341	134	10	contains	contain	VERB
fnp-3341	134	11	laminin	laminin	NOUN
fnp-3341	134	12	produced	produce	VERB
fnp-3341	134	13	by	by	ADP
fnp-3341	134	14	pericytes	pericyte	NOUN
fnp-3341	134	15	and	and	CCONJ
fnp-3341	134	16	astrocytes	astrocyte	NOUN
fnp-3341	134	17	33,34	33,34	NUM
fnp-3341	134	18	.	.	PUNCT
fnp-3341	135	1	laminin	laminin	NOUN
fnp-3341	135	2	is	be	AUX
fnp-3341	135	3	essential	essential	ADJ
fnp-3341	135	4	for	for	ADP
fnp-3341	135	5	basement	basement	NOUN
fnp-3341	135	6	membrane	membrane	NOUN
fnp-3341	135	7	assembly	assembly	NOUN
fnp-3341	135	8	and	and	CCONJ
fnp-3341	135	9	maintenance	maintenance	NOUN
fnp-3341	135	10	of	of	ADP
fnp-3341	135	11	nvu	nvu	NOUN
fnp-3341	135	12	integrity	integrity	NOUN
fnp-3341	135	13	35	35	NUM
fnp-3341	135	14	.	.	PUNCT
fnp-3341	136	1	in	in	ADP
fnp-3341	136	2	our	our	PRON
fnp-3341	136	3	study	study	NOUN
fnp-3341	136	4	,	,	PUNCT
fnp-3341	136	5	employing	employ	VERB
fnp-3341	136	6	a	a	DET
fnp-3341	136	7	panlaminin	panlaminin	ADJ
fnp-3341	136	8	antibody	antibody	NOUN
fnp-3341	136	9	,	,	PUNCT
fnp-3341	136	10	we	we	PRON
fnp-3341	136	11	found	find	VERB
fnp-3341	136	12	that	that	SCONJ
fnp-3341	136	13	expression	expression	NOUN
fnp-3341	136	14	of	of	ADP
fnp-3341	136	15	laminin	laminin	NOUN
fnp-3341	136	16	was	be	AUX
fnp-3341	136	17	lower	low	ADJ
fnp-3341	136	18	at	at	ADP
fnp-3341	136	19	the	the	DET
fnp-3341	136	20	glial	glial	ADJ
fnp-3341	136	21	basement	basement	NOUN
fnp-3341	136	22	membrane	membrane	NOUN
fnp-3341	136	23	in	in	ADP
fnp-3341	136	24	both	both	PRON
fnp-3341	136	25	dipg	dipg	NOUN
fnp-3341	136	26	biopsy	biopsy	NOUN
fnp-3341	136	27	and	and	CCONJ
fnp-3341	136	28	autopsy	autopsy	ADJ
fnp-3341	136	29	samples	sample	NOUN
fnp-3341	136	30	.	.	PUNCT
fnp-3341	137	1	this	this	PRON
fnp-3341	137	2	was	be	AUX
fnp-3341	137	3	observed	observe	VERB
fnp-3341	137	4	in	in	ADP
fnp-3341	137	5	pre	pre	ADJ
fnp-3341	137	6	-	-	ADJ
fnp-3341	137	7	existent	existent	ADJ
fnp-3341	137	8	vessels	vessel	NOUN
fnp-3341	137	9	amongst	amongst	ADP
fnp-3341	137	10	the	the	DET
fnp-3341	137	11	tumor	tumor	NOUN
fnp-3341	137	12	cells	cell	NOUN
fnp-3341	137	13	and	and	CCONJ
fnp-3341	137	14	in	in	ADP
fnp-3341	137	15	neovascular	neovascular	NOUN
fnp-3341	137	16	proliferation	proliferation	NOUN
fnp-3341	137	17	.	.	PUNCT
fnp-3341	138	1	our	our	PRON
fnp-3341	138	2	results	result	NOUN
fnp-3341	138	3	suggest	suggest	VERB
fnp-3341	138	4	a	a	DET
fnp-3341	138	5	pathological	pathological	ADJ
fnp-3341	138	6	involvement	involvement	NOUN
fnp-3341	138	7	of	of	ADP
fnp-3341	138	8	pericytes	pericyte	NOUN
fnp-3341	138	9	and	and	CCONJ
fnp-3341	138	10	astrocytes	astrocyte	NOUN
fnp-3341	138	11	in	in	ADP
fnp-3341	138	12	dipg	dipg	NOUN
fnp-3341	138	13	that	that	PRON
fnp-3341	138	14	could	could	AUX
fnp-3341	138	15	have	have	VERB
fnp-3341	138	16	consequences	consequence	NOUN
fnp-3341	138	17	on	on	ADP
fnp-3341	138	18	the	the	DET
fnp-3341	138	19	behavior	behavior	NOUN
fnp-3341	138	20	of	of	ADP
fnp-3341	138	21	the	the	DET
fnp-3341	138	22	endothelial	endothelial	ADJ
fnp-3341	138	23	cells	cell	NOUN
fnp-3341	138	24	,	,	PUNCT
fnp-3341	138	25	thus	thus	ADV
fnp-3341	138	26	also	also	ADV
fnp-3341	138	27	disrupting	disrupt	VERB
fnp-3341	138	28	the	the	DET
fnp-3341	138	29	integrity	integrity	NOUN
fnp-3341	138	30	of	of	ADP
fnp-3341	138	31	the	the	DET
fnp-3341	138	32	nvu	nvu	NOUN
fnp-3341	138	33	34	34	NUM
fnp-3341	138	34	.	.	PUNCT
fnp-3341	139	1	immunohistochemistry	immunohistochemistry	PROPN
fnp-3341	139	2	showed	show	VERB
fnp-3341	139	3	also	also	ADV
fnp-3341	139	4	a	a	DET
fnp-3341	139	5	lower	low	ADJ
fnp-3341	139	6	expression	expression	NOUN
fnp-3341	139	7	of	of	ADP
fnp-3341	139	8	pdgfr	pdgfr	NOUN
fnp-3341	139	9	-	-	PUNCT
fnp-3341	139	10	β	β	NOUN
fnp-3341	139	11	in	in	ADP
fnp-3341	139	12	dipg	dipg	PROPN
fnp-3341	139	13	biopsy	biopsy	PROPN
fnp-3341	139	14	and	and	CCONJ
fnp-3341	139	15	autopsy	autopsy	ADJ
fnp-3341	139	16	samples	sample	NOUN
fnp-3341	139	17	,	,	PUNCT
fnp-3341	139	18	suggesting	suggest	VERB
fnp-3341	139	19	a	a	DET
fnp-3341	139	20	reduction	reduction	NOUN
fnp-3341	139	21	in	in	ADP
fnp-3341	139	22	pericytic	pericytic	ADJ
fnp-3341	139	23	coverage	coverage	NOUN
fnp-3341	139	24	in	in	ADP
fnp-3341	139	25	dipg	dipg	PROPN
fnp-3341	139	26	nvu	nvu	NOUN
fnp-3341	139	27	.	.	PUNCT
fnp-3341	140	1	besides	besides	SCONJ
fnp-3341	140	2	contributing	contribute	VERB
fnp-3341	140	3	to	to	ADP
fnp-3341	140	4	secretion	secretion	NOUN
fnp-3341	140	5	of	of	ADP
fnp-3341	140	6	basement	basement	NOUN
fnp-3341	140	7	membrane	membrane	NOUN
fnp-3341	140	8	components	component	NOUN
fnp-3341	140	9	33,34	33,34	NUM
fnp-3341	140	10	,	,	PUNCT
fnp-3341	140	11	pericytes	pericyte	NOUN
fnp-3341	140	12	are	be	AUX
fnp-3341	140	13	essential	essential	ADJ
fnp-3341	140	14	for	for	ADP
fnp-3341	140	15	regulating	regulate	VERB
fnp-3341	140	16	capillary	capillary	ADJ
fnp-3341	140	17	diameter	diameter	NOUN
fnp-3341	140	18	and	and	CCONJ
fnp-3341	140	19	vessel	vessel	NOUN
fnp-3341	140	20	stability	stability	NOUN
fnp-3341	140	21	13	13	NUM
fnp-3341	140	22	.	.	PUNCT
fnp-3341	141	1	the	the	DET
fnp-3341	141	2	possible	possible	ADJ
fnp-3341	141	3	reduction	reduction	NOUN
fnp-3341	141	4	of	of	ADP
fnp-3341	141	5	pericytic	pericytic	ADJ
fnp-3341	141	6	coverage	coverage	NOUN
fnp-3341	141	7	observed	observe	VERB
fnp-3341	141	8	in	in	ADP
fnp-3341	141	9	our	our	PRON
fnp-3341	141	10	study	study	NOUN
fnp-3341	141	11	may	may	AUX
fnp-3341	141	12	explain	explain	VERB
fnp-3341	141	13	the	the	DET
fnp-3341	141	14	possible	possible	ADJ
fnp-3341	141	15	downregulation	downregulation	NOUN
fnp-3341	141	16	of	of	ADP
fnp-3341	141	17	laminin	laminin	NOUN
fnp-3341	141	18	at	at	ADP
fnp-3341	141	19	the	the	DET
fnp-3341	141	20	glial	glial	ADJ
fnp-3341	141	21	basement	basement	NOUN
fnp-3341	141	22	membrane	membrane	NOUN
fnp-3341	141	23	in	in	ADP
fnp-3341	141	24	dipg	dipg	NOUN
fnp-3341	141	25	patients	patient	NOUN
fnp-3341	141	26	.	.	PUNCT
fnp-3341	142	1	under	under	ADP
fnp-3341	142	2	physiological	physiological	ADJ
fnp-3341	142	3	conditions	condition	NOUN
fnp-3341	142	4	,	,	PUNCT
fnp-3341	142	5	p	p	NOUN
fnp-3341	142	6	-	-	PUNCT
fnp-3341	142	7	gp	gp	NOUN
fnp-3341	142	8	and	and	CCONJ
fnp-3341	142	9	bcrp	bcrp	ADV
fnp-3341	142	10	are	be	AUX
fnp-3341	142	11	the	the	DET
fnp-3341	142	12	most	most	ADV
fnp-3341	142	13	dominantly	dominantly	ADV
fnp-3341	142	14	expressed	express	VERB
fnp-3341	142	15	efflux	efflux	NOUN
fnp-3341	142	16	transporters	transporter	NOUN
fnp-3341	142	17	in	in	ADP
fnp-3341	142	18	de	de	X
fnp-3341	142	19	bbb	bbb	PROPN
fnp-3341	142	20	36,37	36,37	NOUN
fnp-3341	142	21	.	.	PUNCT
fnp-3341	143	1	our	our	PRON
fnp-3341	143	2	study	study	NOUN
fnp-3341	143	3	shows	show	VERB
fnp-3341	143	4	a	a	DET
fnp-3341	143	5	decreased	decrease	VERB
fnp-3341	143	6	p	p	NOUN
fnp-3341	143	7	-	-	PUNCT
fnp-3341	143	8	gp	gp	NOUN
fnp-3341	143	9	expression	expression	NOUN
fnp-3341	143	10	and	and	CCONJ
fnp-3341	143	11	unchanged	unchanged	ADJ
fnp-3341	143	12	bcrp	bcrp	ADJ
fnp-3341	143	13	expression	expression	NOUN
fnp-3341	143	14	in	in	ADP
fnp-3341	143	15	dipg	dipg	NOUN
fnp-3341	143	16	pre	pre	NOUN
fnp-3341	143	17	-	-	NOUN
fnp-3341	143	18	treatment	treatment	NOUN
fnp-3341	143	19	and	and	CCONJ
fnp-3341	143	20	post	post	ADJ
fnp-3341	143	21	-	-	ADJ
fnp-3341	143	22	mortem	mortem	ADJ
fnp-3341	143	23	samples	sample	NOUN
fnp-3341	143	24	.	.	PUNCT
fnp-3341	144	1	this	this	PRON
fnp-3341	144	2	is	be	AUX
fnp-3341	144	3	in	in	ADP
fnp-3341	144	4	line	line	NOUN
fnp-3341	144	5	with	with	ADP
fnp-3341	144	6	previous	previous	ADJ
fnp-3341	144	7	work	work	NOUN
fnp-3341	144	8	showing	show	VERB
fnp-3341	144	9	a	a	DET
fnp-3341	144	10	“	"	PUNCT
fnp-3341	144	11	moderate	moderate	ADJ
fnp-3341	144	12	expression	expression	NOUN
fnp-3341	144	13	”	"	PUNCT
fnp-3341	144	14	of	of	ADP
fnp-3341	144	15	p	p	NOUN
fnp-3341	144	16	-	-	PUNCT
fnp-3341	144	17	gp	gp	NOUN
fnp-3341	144	18	and	and	CCONJ
fnp-3341	144	19	intense	intense	ADJ
fnp-3341	144	20	staining	staining	NOUN
fnp-3341	144	21	of	of	ADP
fnp-3341	144	22	bcrp	bcrp	ADV
fnp-3341	144	23	in	in	ADP
fnp-3341	144	24	dipg	dipg	PROPN
fnp-3341	144	25	tumor	tumor	NOUN
fnp-3341	144	26	vasculature	vasculature	NOUN
fnp-3341	144	27	10	10	NUM
fnp-3341	144	28	.	.	PUNCT
fnp-3341	145	1	overall	overall	ADV
fnp-3341	145	2	,	,	PUNCT
fnp-3341	145	3	our	our	PRON
fnp-3341	145	4	results	result	NOUN
fnp-3341	145	5	show	show	VERB
fnp-3341	145	6	alterations	alteration	NOUN
fnp-3341	145	7	of	of	ADP
fnp-3341	145	8	the	the	DET
fnp-3341	145	9	nvu	nvu	NOUN
fnp-3341	145	10	in	in	ADP
fnp-3341	145	11	dipg	dipg	NOUN
fnp-3341	145	12	patients	patient	NOUN
fnp-3341	145	13	,	,	PUNCT
fnp-3341	145	14	which	which	PRON
fnp-3341	145	15	could	could	AUX
fnp-3341	145	16	result	result	VERB
fnp-3341	145	17	in	in	ADP
fnp-3341	145	18	or	or	CCONJ
fnp-3341	145	19	reflect	reflect	VERB
fnp-3341	145	20	a	a	DET
fnp-3341	145	21	more	more	ADV
fnp-3341	145	22	leaky	leaky	ADJ
fnp-3341	145	23	nvu	nvu	NOUN
fnp-3341	145	24	.	.	PUNCT
fnp-3341	146	1	this	this	DET
fnp-3341	146	2	hypothesis	hypothesis	NOUN
fnp-3341	146	3	of	of	ADP
fnp-3341	146	4	a	a	DET
fnp-3341	146	5	leaky	leaky	ADJ
fnp-3341	146	6	nvu	nvu	NOUN
fnp-3341	146	7	is	be	AUX
fnp-3341	146	8	supported	support	VERB
fnp-3341	146	9	by	by	ADP
fnp-3341	146	10	the	the	DET
fnp-3341	146	11	demonstrated	demonstrate	VERB
fnp-3341	146	12	extravasation	extravasation	NOUN
fnp-3341	146	13	of	of	ADP
fnp-3341	146	14	some	some	DET
fnp-3341	146	15	intravascular	intravascular	ADJ
fnp-3341	146	16	proteins	protein	NOUN
fnp-3341	146	17	,	,	PUNCT
fnp-3341	146	18	such	such	ADJ
fnp-3341	146	19	as	as	ADP
fnp-3341	146	20	pre	pre	ADJ
fnp-3341	146	21	-	-	ADJ
fnp-3341	146	22	albumin	albumin	ADJ
fnp-3341	146	23	,	,	PUNCT
fnp-3341	146	24	fibrinogen	fibrinogen	NOUN
fnp-3341	146	25	and	and	CCONJ
fnp-3341	146	26	igg	igg	PROPN
fnp-3341	146	27	.	.	PUNCT
fnp-3341	147	1	theoretically	theoretically	ADV
fnp-3341	147	2	,	,	PUNCT
fnp-3341	147	3	this	this	PRON
fnp-3341	147	4	might	might	AUX
fnp-3341	147	5	positively	positively	ADV
fnp-3341	147	6	influence	influence	VERB
fnp-3341	147	7	influx	influx	NOUN
fnp-3341	147	8	of	of	ADP
fnp-3341	147	9	chemotherapeutic	chemotherapeutic	ADJ
fnp-3341	147	10	agents	agent	NOUN
fnp-3341	147	11	into	into	ADP
fnp-3341	147	12	the	the	DET
fnp-3341	147	13	tumor	tumor	NOUN
fnp-3341	147	14	,	,	PUNCT
fnp-3341	147	15	based	base	VERB
fnp-3341	147	16	on	on	ADP
fnp-3341	147	17	passive	passive	ADJ
fnp-3341	147	18	diffusion	diffusion	NOUN
fnp-3341	147	19	.	.	PUNCT
fnp-3341	148	1	clinical	clinical	ADJ
fnp-3341	148	2	data	datum	NOUN
fnp-3341	148	3	,	,	PUNCT
fnp-3341	148	4	however	however	ADV
fnp-3341	148	5	,	,	PUNCT
fnp-3341	148	6	do	do	AUX
fnp-3341	148	7	not	not	PART
fnp-3341	148	8	support	support	VERB
fnp-3341	148	9	this	this	DET
fnp-3341	148	10	possibility	possibility	NOUN
fnp-3341	148	11	38,39	38,39	NOUN
fnp-3341	148	12	.	.	PUNCT
fnp-3341	149	1	a	a	DET
fnp-3341	149	2	possible	possible	ADJ
fnp-3341	149	3	explanation	explanation	NOUN
fnp-3341	149	4	for	for	ADP
fnp-3341	149	5	this	this	DET
fnp-3341	149	6	discrepancy	discrepancy	NOUN
fnp-3341	149	7	might	might	AUX
fnp-3341	149	8	be	be	AUX
fnp-3341	149	9	the	the	DET
fnp-3341	149	10	markedly	markedly	ADV
fnp-3341	149	11	reduced	reduce	VERB
fnp-3341	149	12	vascular	vascular	ADJ
fnp-3341	149	13	density	density	NOUN
fnp-3341	149	14	in	in	ADP
fnp-3341	149	15	dipg	dipg	NOUN
fnp-3341	149	16	that	that	PRON
fnp-3341	149	17	could	could	AUX
fnp-3341	149	18	overrule	overrule	VERB
fnp-3341	149	19	the	the	DET
fnp-3341	149	20	effects	effect	NOUN
fnp-3341	149	21	of	of	ADP
fnp-3341	149	22	a	a	DET
fnp-3341	149	23	leaky	leaky	ADJ
fnp-3341	149	24	nvu	nvu	NOUN
fnp-3341	149	25	.	.	PUNCT
fnp-3341	150	1	whether	whether	SCONJ
fnp-3341	150	2	the	the	DET
fnp-3341	150	3	reduction	reduction	NOUN
fnp-3341	150	4	of	of	ADP
fnp-3341	150	5	vascular	vascular	ADJ
fnp-3341	150	6	density	density	NOUN
fnp-3341	150	7	is	be	AUX
fnp-3341	150	8	also	also	ADV
fnp-3341	150	9	present	present	ADJ
fnp-3341	150	10	at	at	ADP
fnp-3341	150	11	diagnosis	diagnosis	NOUN
fnp-3341	150	12	remains	remain	VERB
fnp-3341	150	13	to	to	PART
fnp-3341	150	14	be	be	AUX
fnp-3341	150	15	investigated	investigate	VERB
fnp-3341	150	16	.	.	PUNCT
fnp-3341	151	1	lack	lack	NOUN
fnp-3341	151	2	of	of	ADP
fnp-3341	151	3	therapy	therapy	NOUN
fnp-3341	151	4	efficacy	efficacy	NOUN
fnp-3341	151	5	in	in	ADP
fnp-3341	151	6	dipg	dipg	NOUN
fnp-3341	151	7	has	have	AUX
fnp-3341	151	8	been	be	AUX
fnp-3341	151	9	linked	link	VERB
fnp-3341	151	10	to	to	ADP
fnp-3341	151	11	an	an	DET
fnp-3341	151	12	intact	intact	ADJ
fnp-3341	151	13	bbb	bbb	NOUN
fnp-3341	151	14	.	.	PUNCT
fnp-3341	152	1	here	here	ADV
fnp-3341	152	2	,	,	PUNCT
fnp-3341	152	3	we	we	PRON
fnp-3341	152	4	demonstrated	demonstrate	VERB
fnp-3341	152	5	structural	structural	ADJ
fnp-3341	152	6	changes	change	NOUN
fnp-3341	152	7	of	of	ADP
fnp-3341	152	8	the	the	DET
fnp-3341	152	9	nvu	nvu	NOUN
fnp-3341	152	10	together	together	ADV
fnp-3341	152	11	with	with	ADP
fnp-3341	152	12	a	a	DET
fnp-3341	152	13	lower	low	ADJ
fnp-3341	152	14	vascular	vascular	ADJ
fnp-3341	152	15	density	density	NOUN
fnp-3341	152	16	in	in	ADP
fnp-3341	152	17	these	these	DET
fnp-3341	152	18	tumors	tumor	NOUN
fnp-3341	152	19	.	.	PUNCT
fnp-3341	153	1	these	these	DET
fnp-3341	153	2	findings	finding	NOUN
fnp-3341	153	3	have	have	VERB
fnp-3341	153	4	consequences	consequence	NOUN
fnp-3341	153	5	for	for	ADP
fnp-3341	153	6	drug	drug	NOUN
fnp-3341	153	7	administration	administration	NOUN
fnp-3341	153	8	,	,	PUNCT
fnp-3341	153	9	since	since	SCONJ
fnp-3341	153	10	coverage	coverage	NOUN
fnp-3341	153	11	of	of	ADP
fnp-3341	153	12	the	the	DET
fnp-3341	153	13	whole	whole	ADJ
fnp-3341	153	14	tumor	tumor	NOUN
fnp-3341	153	15	,	,	PUNCT
fnp-3341	153	16	including	include	VERB
fnp-3341	153	17	the	the	DET
fnp-3341	153	18	migrating	migrating	NOUN
fnp-3341	153	19	/	/	SYM
fnp-3341	153	20	diffusely	diffusely	ADV
fnp-3341	153	21	growing	grow	VERB
fnp-3341	153	22	tumor	tumor	NOUN
fnp-3341	153	23	cells	cell	NOUN
fnp-3341	153	24	,	,	PUNCT
fnp-3341	153	25	is	be	AUX
fnp-3341	153	26	essential	essential	ADJ
fnp-3341	153	27	.	.	PUNCT
fnp-3341	154	1	our	our	PRON
fnp-3341	154	2	findings	finding	NOUN
fnp-3341	154	3	suggest	suggest	VERB
fnp-3341	154	4	that	that	SCONJ
fnp-3341	154	5	drug	drug	NOUN
fnp-3341	154	6	administration	administration	NOUN
fnp-3341	154	7	techniques	technique	NOUN
fnp-3341	154	8	that	that	PRON
fnp-3341	154	9	mostly	mostly	ADV
fnp-3341	154	10	rely	rely	VERB
fnp-3341	154	11	on	on	ADP
fnp-3341	154	12	vascular	vascular	ADJ
fnp-3341	154	13	density	density	NOUN
fnp-3341	154	14	for	for	ADP
fnp-3341	154	15	drug	drug	NOUN
fnp-3341	154	16	distribution	distribution	NOUN
fnp-3341	154	17	,	,	PUNCT
fnp-3341	154	18	including	include	VERB
fnp-3341	154	19	conventional	conventional	ADJ
fnp-3341	154	20	systemic	systemic	ADJ
fnp-3341	154	21	administration	administration	NOUN
fnp-3341	154	22	and	and	CCONJ
fnp-3341	154	23	microbubble	microbubble	ADJ
fnp-3341	154	24	mediated	mediate	VERB
fnp-3341	154	25	focused	focused	ADJ
fnp-3341	154	26	ultrasound	ultrasound	NOUN
fnp-3341	154	27	,	,	PUNCT
fnp-3341	154	28	might	might	AUX
fnp-3341	154	29	show	show	VERB
fnp-3341	154	30	limited	limited	ADJ
fnp-3341	154	31	efficacy	efficacy	NOUN
fnp-3341	154	32	in	in	ADP
fnp-3341	154	33	dipg	dipg	PROPN
fnp-3341	154	34	12	12	NUM
fnp-3341	154	35	.	.	PUNCT
fnp-3341	155	1	in	in	ADP
fnp-3341	155	2	contrast	contrast	NOUN
fnp-3341	155	3	,	,	PUNCT
fnp-3341	155	4	convection	convection	NOUN
fnp-3341	155	5	-	-	PUNCT
fnp-3341	155	6	enhanced	enhance	VERB
fnp-3341	155	7	delivery	delivery	NOUN
fnp-3341	155	8	might	might	AUX
fnp-3341	155	9	be	be	AUX
fnp-3341	155	10	a	a	DET
fnp-3341	155	11	more	more	ADV
fnp-3341	155	12	suitable	suitable	ADJ
fnp-3341	155	13	technique	technique	NOUN
fnp-3341	155	14	,	,	PUNCT
fnp-3341	155	15	in	in	ADP
fnp-3341	155	16	which	which	PRON
fnp-3341	155	17	drug	drug	NOUN
fnp-3341	155	18	distribution	distribution	NOUN
fnp-3341	155	19	across	across	ADP
fnp-3341	155	20	the	the	DET
fnp-3341	155	21	tumor	tumor	NOUN
fnp-3341	155	22	relies	rely	VERB
fnp-3341	155	23	on	on	ADP
fnp-3341	155	24	a	a	DET
fnp-3341	155	25	positive	positive	ADJ
fnp-3341	155	26	pressure	pressure	NOUN
fnp-3341	155	27	gradient	gradient	NOUN
fnp-3341	155	28	instead	instead	ADV
fnp-3341	155	29	of	of	ADP
fnp-3341	155	30	passive	passive	ADJ
fnp-3341	155	31	diffusion	diffusion	NOUN
fnp-3341	155	32	12,40,41	12,40,41	NOUN
fnp-3341	155	33	.	.	PUNCT
fnp-3341	155	34	adding	add	VERB
fnp-3341	155	35	such	such	DET
fnp-3341	155	36	a	a	DET
fnp-3341	155	37	biological	biological	ADJ
fnp-3341	155	38	nvu	nvu	NOUN
fnp-3341	155	39	perspective	perspective	NOUN
fnp-3341	155	40	may	may	AUX
fnp-3341	155	41	help	help	VERB
fnp-3341	155	42	to	to	PART
fnp-3341	155	43	better	better	VERB
fnp-3341	155	44	direct	direct	VERB
fnp-3341	155	45	treatment	treatment	NOUN
fnp-3341	155	46	choices	choice	NOUN
fnp-3341	155	47	for	for	ADP
fnp-3341	155	48	dipg	dipg	NOUN
fnp-3341	155	49	patients	patient	NOUN
fnp-3341	155	50	in	in	ADP
fnp-3341	155	51	the	the	DET
fnp-3341	155	52	future	future	NOUN
fnp-3341	155	53	.	.	PUNCT
fnp-3341	156	1	acknowledgement	acknowledgement	NOUN
fnp-3341	156	2	we	we	PRON
fnp-3341	156	3	thank	thank	VERB
fnp-3341	156	4	the	the	DET
fnp-3341	156	5	employees	employee	NOUN
fnp-3341	156	6	of	of	ADP
fnp-3341	156	7	the	the	DET
fnp-3341	156	8	expertise	expertise	NOUN
fnp-3341	156	9	center	center	NOUN
fnp-3341	156	10	for	for	ADP
fnp-3341	156	11	post	post	ADJ
fnp-3341	156	12	-	-	ADJ
fnp-3341	156	13	mortem	mortem	ADJ
fnp-3341	156	14	diagnostics	diagnostic	NOUN
fnp-3341	156	15	of	of	ADP
fnp-3341	156	16	the	the	DET
fnp-3341	156	17	amsterdam	amsterdam	PROPN
fnp-3341	156	18	university	university	PROPN
fnp-3341	156	19	medical	medical	ADJ
fnp-3341	156	20	centers	center	NOUN
fnp-3341	156	21	,	,	PUNCT
fnp-3341	156	22	location	location	NOUN
fnp-3341	156	23	vumc	vumc	NOUN
fnp-3341	156	24	,	,	PUNCT
fnp-3341	156	25	for	for	ADP
fnp-3341	156	26	assisting	assist	VERB
fnp-3341	156	27	with	with	ADP
fnp-3341	156	28	the	the	DET
fnp-3341	156	29	autopsies	autopsy	NOUN
fnp-3341	156	30	of	of	ADP
fnp-3341	156	31	the	the	DET
fnp-3341	156	32	dipg	dipg	NOUN
fnp-3341	156	33	patients	patient	NOUN
fnp-3341	156	34	.	.	PUNCT
fnp-3341	157	1	we	we	PRON
fnp-3341	157	2	also	also	ADV
fnp-3341	157	3	thank	thank	VERB
fnp-3341	157	4	the	the	DET
fnp-3341	157	5	nih	nih	PROPN
fnp-3341	157	6	neurobiobank	neurobiobank	PROPN
fnp-3341	157	7	for	for	ADP
fnp-3341	157	8	providing	provide	VERB
fnp-3341	157	9	the	the	DET
fnp-3341	157	10	control	control	NOUN
fnp-3341	157	11	tissue	tissue	NOUN
fnp-3341	157	12	.	.	PUNCT
fnp-3341	158	1	we	we	PRON
fnp-3341	158	2	would	would	AUX
fnp-3341	158	3	also	also	ADV
fnp-3341	158	4	like	like	VERB
fnp-3341	158	5	to	to	PART
fnp-3341	158	6	thank	thank	VERB
fnp-3341	158	7	the	the	DET
fnp-3341	158	8	semmy	semmy	PROPN
fnp-3341	158	9	foundation	foundation	PROPN
fnp-3341	158	10	(	(	PUNCT
fnp-3341	158	11	stichting	stichting	NOUN
fnp-3341	158	12	semmy	semmy	PROPN
fnp-3341	158	13	)	)	PUNCT
fnp-3341	158	14	for	for	ADP
fnp-3341	158	15	financially	financially	ADV
fnp-3341	158	16	supporting	support	VERB
fnp-3341	158	17	dipg	dipg	NOUN
fnp-3341	158	18	research	research	NOUN
fnp-3341	158	19	in	in	ADP
fnp-3341	158	20	the	the	DET
fnp-3341	158	21	amsterdam	amsterdam	PROPN
fnp-3341	158	22	university	university	PROPN
fnp-3341	158	23	medical	medical	ADJ
fnp-3341	158	24	centers	center	NOUN
fnp-3341	158	25	,	,	PUNCT
fnp-3341	158	26	location	location	NOUN
fnp-3341	158	27	vumc	vumc	NOUN
fnp-3341	158	28	.	.	PUNCT
fnp-3341	159	1	ethical	ethical	ADJ
fnp-3341	159	2	approval	approval	NOUN
fnp-3341	159	3	the	the	DET
fnp-3341	159	4	study	study	NOUN
fnp-3341	159	5	was	be	AUX
fnp-3341	159	6	approved	approve	VERB
fnp-3341	159	7	by	by	ADP
fnp-3341	159	8	the	the	DET
fnp-3341	159	9	medical	medical	PROPN
fnp-3341	159	10	ethical	ethical	PROPN
fnp-3341	159	11	committee	committee	NOUN
fnp-3341	159	12	of	of	ADP
fnp-3341	159	13	the	the	DET
fnp-3341	159	14	amsterdam	amsterdam	PROPN
fnp-3341	159	15	university	university	PROPN
fnp-3341	159	16	medical	medical	ADJ
fnp-3341	159	17	center	center	NOUN
fnp-3341	159	18	,	,	PUNCT
fnp-3341	159	19	location	location	NOUN
fnp-3341	159	20	vumc	vumc	NOUN
fnp-3341	159	21	(	(	PUNCT
fnp-3341	159	22	metc	metc	ADJ
fnp-3341	159	23	vumc	vumc	NOUN
fnp-3341	159	24	,	,	PUNCT
fnp-3341	159	25	study	study	NOUN
fnp-3341	159	26	number	number	NOUN
fnp-3341	159	27	vumc2009/237	vumc2009/237	PROPN
fnp-3341	159	28	)	)	PUNCT
fnp-3341	159	29	.	.	PUNCT
fnp-3341	160	1	this	this	DET
fnp-3341	160	2	study	study	NOUN
fnp-3341	160	3	was	be	AUX
fnp-3341	160	4	conducted	conduct	VERB
fnp-3341	160	5	in	in	ADP
fnp-3341	160	6	accordance	accordance	NOUN
fnp-3341	160	7	to	to	ADP
fnp-3341	160	8	the	the	DET
fnp-3341	160	9	declaration	declaration	NOUN
fnp-3341	160	10	of	of	ADP
fnp-3341	160	11	helsinki	helsinki	PROPN
fnp-3341	160	12	.	.	PUNCT
fnp-3341	161	1	data	data	PROPN
fnp-3341	161	2	sharing	sharing	NOUN
fnp-3341	161	3	and	and	CCONJ
fnp-3341	161	4	data	datum	NOUN
fnp-3341	161	5	accessibility	accessibility	NOUN
fnp-3341	161	6	the	the	DET
fnp-3341	161	7	data	datum	NOUN
fnp-3341	161	8	that	that	PRON
fnp-3341	161	9	support	support	VERB
fnp-3341	161	10	the	the	DET
fnp-3341	161	11	findings	finding	NOUN
fnp-3341	161	12	of	of	ADP
fnp-3341	161	13	this	this	DET
fnp-3341	161	14	study	study	NOUN
fnp-3341	161	15	are	be	AUX
fnp-3341	161	16	available	available	ADJ
fnp-3341	161	17	from	from	ADP
fnp-3341	161	18	the	the	DET
fnp-3341	161	19	corresponding	corresponding	ADJ
fnp-3341	161	20	author	author	NOUN
fnp-3341	161	21	upon	upon	SCONJ
fnp-3341	161	22	reasonable	reasonable	ADJ
fnp-3341	161	23	request	request	NOUN
fnp-3341	161	24	.	.	PUNCT
fnp-3341	161	25	  	  	SPACE
fnp-3341	161	26	references	reference	NOUN
fnp-3341	161	27	1	1	NUM
fnp-3341	161	28	.	.	PUNCT
fnp-3341	162	1	epstein	epstein	PROPN
fnp-3341	162	2	f	f	PROPN
fnp-3341	162	3	,	,	PUNCT
fnp-3341	162	4	mccleary	mccleary	PROPN
fnp-3341	162	5	el	el	PROPN
fnp-3341	162	6	.	.	PROPN
fnp-3341	162	7	intrinsic	intrinsic	ADJ
fnp-3341	162	8	brain	brain	NOUN
fnp-3341	162	9	-	-	PUNCT
fnp-3341	162	10	stem	stem	NOUN
fnp-3341	162	11	tumors	tumor	NOUN
fnp-3341	162	12	of	of	ADP
fnp-3341	162	13	childhood	childhood	NOUN
fnp-3341	162	14	:	:	PUNCT
fnp-3341	162	15	surgical	surgical	ADJ
fnp-3341	162	16	indications	indication	NOUN
fnp-3341	162	17	.	.	PUNCT
fnp-3341	163	1	j	j	PROPN
fnp-3341	163	2	neurosurg	neurosurg	PROPN
fnp-3341	163	3	1986	1986	NUM
fnp-3341	163	4	;	;	PUNCT
fnp-3341	163	5	64(1	64(1	NUM
fnp-3341	163	6	):	):	PUNCT
fnp-3341	163	7	11	11	NUM
fnp-3341	163	8	-	-	SYM
fnp-3341	163	9	5	5	NUM
fnp-3341	163	10	.	.	NOUN
fnp-3341	163	11	2	2	NUM
fnp-3341	163	12	.	.	X
fnp-3341	163	13	yoshimura	yoshimura	PROPN
fnp-3341	163	14	j	j	PROPN
fnp-3341	163	15	,	,	PUNCT
fnp-3341	163	16	onda	onda	PROPN
fnp-3341	163	17	k	k	PROPN
fnp-3341	163	18	,	,	PUNCT
fnp-3341	163	19	tanaka	tanaka	PROPN
fnp-3341	163	20	r	r	PROPN
fnp-3341	163	21	,	,	PUNCT
fnp-3341	163	22	takahashi	takahashi	PROPN
fnp-3341	163	23	h.	h.	PROPN
fnp-3341	163	24	clinicopathological	clinicopathological	PROPN
fnp-3341	163	25	study	study	NOUN
fnp-3341	163	26	of	of	ADP
fnp-3341	163	27	diffuse	diffuse	NOUN
fnp-3341	163	28	type	type	NOUN
fnp-3341	163	29	brainstem	brainstem	NOUN
fnp-3341	163	30	gliomas	glioma	NOUN
fnp-3341	163	31	 	 	SPACE
fnp-3341	163	32	:	:	PUNCT
fnp-3341	163	33	analysis	analysis	NOUN
fnp-3341	163	34	of	of	ADP
fnp-3341	163	35	40	40	NUM
fnp-3341	163	36	autopsy	autopsy	ADJ
fnp-3341	163	37	cases	case	NOUN
fnp-3341	163	38	.	.	PUNCT
fnp-3341	164	1	neurol	neurol	PROPN
fnp-3341	164	2	med	me	VERB
fnp-3341	164	3	chir	chir	ADJ
fnp-3341	164	4	(	(	PUNCT
fnp-3341	164	5	tokyo	tokyo	PROPN
fnp-3341	164	6	)	)	PUNCT
fnp-3341	164	7	2003	2003	NUM
fnp-3341	164	8	;	;	PUNCT
fnp-3341	164	9	43	43	NUM
fnp-3341	164	10	:	:	SYM
fnp-3341	164	11	375	375	NUM
fnp-3341	164	12	-	-	SYM
fnp-3341	164	13	82	82	NUM
fnp-3341	164	14	.	.	PUNCT
fnp-3341	165	1	3	3	X
fnp-3341	165	2	.	.	X
fnp-3341	165	3	broniscer	broniscer	PROPN
fnp-3341	165	4	a	a	X
fnp-3341	165	5	,	,	PUNCT
fnp-3341	165	6	gajjar	gajjar	NOUN
fnp-3341	165	7	a.	a.	NOUN
fnp-3341	165	8	supratentorial	supratentorial	ADJ
fnp-3341	165	9	high	high	ADJ
fnp-3341	165	10	-	-	PUNCT
fnp-3341	165	11	grade	grade	NOUN
fnp-3341	165	12	astrocytoma	astrocytoma	NOUN
fnp-3341	165	13	and	and	CCONJ
fnp-3341	165	14	diffuse	diffuse	ADJ
fnp-3341	165	15	brainstem	brainstem	NOUN
fnp-3341	165	16	glioma	glioma	NOUN
fnp-3341	165	17	:	:	PUNCT
fnp-3341	165	18	two	two	NUM
fnp-3341	165	19	challenges	challenge	NOUN
fnp-3341	165	20	for	for	ADP
fnp-3341	165	21	the	the	DET
fnp-3341	165	22	pediatric	pediatric	ADJ
fnp-3341	165	23	oncologist	oncologist	NOUN
fnp-3341	165	24	.	.	PUNCT
fnp-3341	166	1	oncologist	oncologist	NOUN
fnp-3341	166	2	2004	2004	NUM
fnp-3341	166	3	;	;	PUNCT
fnp-3341	166	4	9(2	9(2	NUM
fnp-3341	166	5	):	):	PUNCT
fnp-3341	166	6	197	197	NUM
fnp-3341	166	7	-	-	SYM
fnp-3341	166	8	206	206	NUM
fnp-3341	166	9	.	.	PUNCT
fnp-3341	167	1	4	4	X
fnp-3341	167	2	.	.	X
fnp-3341	167	3	hargrave	hargrave	PROPN
fnp-3341	167	4	d	d	PROPN
fnp-3341	167	5	,	,	PUNCT
fnp-3341	167	6	bartels	bartels	PROPN
fnp-3341	167	7	u	u	PROPN
fnp-3341	167	8	,	,	PUNCT
fnp-3341	167	9	bouffet	bouffet	VERB
fnp-3341	167	10	e.	e.	PROPN
fnp-3341	167	11	diffuse	diffuse	PROPN
fnp-3341	167	12	brainstem	brainstem	NOUN
fnp-3341	167	13	glioma	glioma	NOUN
fnp-3341	167	14	in	in	ADP
fnp-3341	167	15	children	child	NOUN
fnp-3341	167	16	:	:	PUNCT
fnp-3341	167	17	critical	critical	ADJ
fnp-3341	167	18	review	review	NOUN
fnp-3341	167	19	of	of	ADP
fnp-3341	167	20	clinical	clinical	ADJ
fnp-3341	167	21	trials	trial	NOUN
fnp-3341	167	22	.	.	PUNCT
fnp-3341	168	1	the	the	DET
fnp-3341	168	2	lancet	lancet	PROPN
fnp-3341	168	3	oncology	oncology	NOUN
fnp-3341	168	4	2006	2006	NUM
fnp-3341	168	5	;	;	PUNCT
fnp-3341	168	6	7(3	7(3	NUM
fnp-3341	168	7	):	):	PUNCT
fnp-3341	168	8	241	241	NUM
fnp-3341	168	9	-	-	SYM
fnp-3341	168	10	8	8	NUM
fnp-3341	168	11	.	.	NOUN
fnp-3341	168	12	5	5	NUM
fnp-3341	168	13	.	.	PUNCT
fnp-3341	168	14	jansen	jansen	PROPN
fnp-3341	168	15	mh	mh	PROPN
fnp-3341	168	16	,	,	PUNCT
fnp-3341	168	17	veldhuijzen	veldhuijzen	PROPN
fnp-3341	168	18	van	van	PROPN
fnp-3341	168	19	zanten	zanten	PROPN
fnp-3341	168	20	se	se	PROPN
fnp-3341	168	21	,	,	PUNCT
fnp-3341	168	22	sanchez	sanchez	PROPN
fnp-3341	168	23	aliaga	aliaga	PROPN
fnp-3341	168	24	e	e	PROPN
fnp-3341	168	25	,	,	PUNCT
fnp-3341	168	26	et	et	PROPN
fnp-3341	168	27	al	al	PROPN
fnp-3341	168	28	.	.	PROPN
fnp-3341	168	29	survival	survival	PROPN
fnp-3341	168	30	prediction	prediction	NOUN
fnp-3341	168	31	model	model	NOUN
fnp-3341	168	32	of	of	ADP
fnp-3341	168	33	children	child	NOUN
fnp-3341	168	34	with	with	ADP
fnp-3341	168	35	diffuse	diffuse	NOUN
fnp-3341	168	36	intrinsic	intrinsic	ADJ
fnp-3341	168	37	pontine	pontine	ADJ
fnp-3341	168	38	glioma	glioma	NOUN
fnp-3341	168	39	based	base	VERB
fnp-3341	168	40	on	on	ADP
fnp-3341	168	41	clinical	clinical	ADJ
fnp-3341	168	42	and	and	CCONJ
fnp-3341	168	43	radiological	radiological	ADJ
fnp-3341	168	44	criteria	criterion	NOUN
fnp-3341	168	45	.	.	PUNCT
fnp-3341	169	1	neuro	neuro	PROPN
fnp-3341	169	2	oncol	oncol	ADJ
fnp-3341	169	3	2015	2015	NUM
fnp-3341	169	4	;	;	PUNCT
fnp-3341	169	5	17(1	17(1	NUM
fnp-3341	169	6	):	):	PUNCT
fnp-3341	169	7	160	160	NUM
fnp-3341	169	8	-	-	SYM
fnp-3341	169	9	6	6	NUM
fnp-3341	169	10	.	.	NOUN
fnp-3341	169	11	6	6	NUM
fnp-3341	169	12	.	.	X
fnp-3341	169	13	veringa	veringa	PROPN
fnp-3341	169	14	sje	sje	PROPN
fnp-3341	169	15	,	,	PUNCT
fnp-3341	169	16	biesmans	biesman	NOUN
fnp-3341	169	17	d	d	NOUN
fnp-3341	169	18	,	,	PUNCT
fnp-3341	169	19	van	van	PROPN
fnp-3341	169	20	vuurden	vuurden	NOUN
fnp-3341	169	21	dg	dg	PROPN
fnp-3341	169	22	,	,	PUNCT
fnp-3341	169	23	et	et	PROPN
fnp-3341	169	24	al	al	PROPN
fnp-3341	169	25	.	.	PROPN
fnp-3341	170	1	in	in	ADP
fnp-3341	170	2	vitro	vitro	X
fnp-3341	170	3	drug	drug	NOUN
fnp-3341	170	4	response	response	NOUN
fnp-3341	170	5	and	and	CCONJ
fnp-3341	170	6	efflux	efflux	VERB
fnp-3341	170	7	transporters	transporter	NOUN
fnp-3341	170	8	associated	associate	VERB
fnp-3341	170	9	with	with	ADP
fnp-3341	170	10	drug	drug	NOUN
fnp-3341	170	11	resistance	resistance	NOUN
fnp-3341	170	12	in	in	ADP
fnp-3341	170	13	pediatric	pediatric	ADJ
fnp-3341	170	14	high	high	ADJ
fnp-3341	170	15	grade	grade	NOUN
fnp-3341	170	16	glioma	glioma	NOUN
fnp-3341	170	17	and	and	CCONJ
fnp-3341	170	18	diffuse	diffuse	VERB
fnp-3341	170	19	intrinsic	intrinsic	ADJ
fnp-3341	170	20	pontine	pontine	ADJ
fnp-3341	170	21	glioma	glioma	NOUN
fnp-3341	170	22	.	.	PUNCT
fnp-3341	171	1	plos	plos	PROPN
fnp-3341	171	2	one	one	NUM
fnp-3341	171	3	2013	2013	NUM
fnp-3341	171	4	;	;	PUNCT
fnp-3341	171	5	8(4	8(4	NUM
fnp-3341	171	6	):	):	PUNCT
fnp-3341	171	7	e61512	e61512	PROPN
fnp-3341	171	8	-	-	PUNCT
fnp-3341	171	9	e.	e.	PROPN
fnp-3341	171	10	7	7	PROPN
fnp-3341	171	11	.	.	PUNCT
fnp-3341	171	12	hoffman	hoffman	PROPN
fnp-3341	171	13	lm	lm	PROPN
fnp-3341	171	14	,	,	PUNCT
fnp-3341	171	15	veldhuijzen	veldhuijzen	NOUN
fnp-3341	171	16	van	van	PROPN
fnp-3341	171	17	zanten	zanten	PROPN
fnp-3341	171	18	sem	sem	PROPN
fnp-3341	171	19	,	,	PUNCT
fnp-3341	171	20	colditz	colditz	PROPN
fnp-3341	171	21	n	n	CCONJ
fnp-3341	171	22	,	,	PUNCT
fnp-3341	171	23	et	et	PROPN
fnp-3341	171	24	al	al	PROPN
fnp-3341	171	25	.	.	PROPN
fnp-3341	171	26	clinical	clinical	ADJ
fnp-3341	171	27	,	,	PUNCT
fnp-3341	171	28	radiologic	radiologic	ADJ
fnp-3341	171	29	,	,	PUNCT
fnp-3341	171	30	pathologic	pathologic	ADJ
fnp-3341	171	31	,	,	PUNCT
fnp-3341	171	32	and	and	CCONJ
fnp-3341	171	33	molecular	molecular	ADJ
fnp-3341	171	34	characteristics	characteristic	NOUN
fnp-3341	171	35	of	of	ADP
fnp-3341	171	36	long	long	ADJ
fnp-3341	171	37	-	-	PUNCT
fnp-3341	171	38	term	term	NOUN
fnp-3341	171	39	survivors	survivor	NOUN
fnp-3341	171	40	of	of	ADP
fnp-3341	171	41	diffuse	diffuse	NOUN
fnp-3341	171	42	intrinsic	intrinsic	ADJ
fnp-3341	171	43	pontine	pontine	ADJ
fnp-3341	171	44	glioma	glioma	NOUN
fnp-3341	171	45	(	(	PUNCT
fnp-3341	171	46	dipg	dipg	PROPN
fnp-3341	171	47	):	):	PUNCT
fnp-3341	171	48	a	a	DET
fnp-3341	171	49	collaborative	collaborative	ADJ
fnp-3341	171	50	report	report	NOUN
fnp-3341	171	51	from	from	ADP
fnp-3341	171	52	the	the	DET
fnp-3341	171	53	international	international	ADJ
fnp-3341	171	54	and	and	CCONJ
fnp-3341	171	55	european	european	ADJ
fnp-3341	171	56	society	society	NOUN
fnp-3341	171	57	for	for	ADP
fnp-3341	171	58	pediatric	pediatric	ADJ
fnp-3341	171	59	oncology	oncology	NOUN
fnp-3341	171	60	dipg	dipg	NOUN
fnp-3341	171	61	registries	registry	NOUN
fnp-3341	171	62	.	.	PUNCT
fnp-3341	172	1	journal	journal	NOUN
fnp-3341	172	2	of	of	ADP
fnp-3341	172	3	clinical	clinical	ADJ
fnp-3341	172	4	oncology	oncology	NOUN
fnp-3341	172	5	2018	2018	NUM
fnp-3341	172	6	;	;	PUNCT
fnp-3341	173	1	36(19	36(19	NUM
fnp-3341	173	2	):	):	PUNCT
fnp-3341	173	3	1963	1963	NUM
fnp-3341	173	4	-	-	SYM
fnp-3341	173	5	72	72	NUM
fnp-3341	173	6	.	.	NOUN
fnp-3341	173	7	8	8	NUM
fnp-3341	173	8	.	.	X
fnp-3341	173	9	louis	louis	PROPN
fnp-3341	173	10	dn	dn	PROPN
fnp-3341	173	11	,	,	PUNCT
fnp-3341	173	12	perry	perry	PROPN
fnp-3341	173	13	a	a	PRON
fnp-3341	173	14	,	,	PUNCT
fnp-3341	173	15	reifenberger	reifenberger	NOUN
fnp-3341	173	16	g	g	NOUN
fnp-3341	173	17	,	,	PUNCT
fnp-3341	173	18	et	et	PROPN
fnp-3341	173	19	al	al	PROPN
fnp-3341	173	20	.	.	PUNCT
fnp-3341	174	1	the	the	DET
fnp-3341	174	2	2016	2016	NUM
fnp-3341	174	3	world	world	PROPN
fnp-3341	174	4	health	health	NOUN
fnp-3341	174	5	organization	organization	NOUN
fnp-3341	174	6	classification	classification	NOUN
fnp-3341	174	7	of	of	ADP
fnp-3341	174	8	tumors	tumor	NOUN
fnp-3341	174	9	of	of	ADP
fnp-3341	174	10	the	the	DET
fnp-3341	174	11	central	central	ADJ
fnp-3341	174	12	nervous	nervous	ADJ
fnp-3341	174	13	system	system	NOUN
fnp-3341	174	14	:	:	PUNCT
fnp-3341	174	15	a	a	DET
fnp-3341	174	16	summary	summary	NOUN
fnp-3341	174	17	.	.	PUNCT
fnp-3341	175	1	acta	acta	PROPN
fnp-3341	175	2	neuropathol	neuropathol	PROPN
fnp-3341	175	3	2016	2016	NUM
fnp-3341	175	4	;	;	PUNCT
fnp-3341	175	5	131(6	131(6	NUM
fnp-3341	175	6	):	):	PUNCT
fnp-3341	175	7	803	803	NUM
fnp-3341	175	8	-	-	SYM
fnp-3341	175	9	20	20	NUM
fnp-3341	175	10	.	.	NOUN
fnp-3341	175	11	9	9	NUM
fnp-3341	175	12	.	.	X
fnp-3341	176	1	sewing	sew	VERB
fnp-3341	176	2	ac	ac	PROPN
fnp-3341	176	3	,	,	PUNCT
fnp-3341	176	4	caretti	caretti	ADJ
fnp-3341	176	5	v	v	NOUN
fnp-3341	176	6	,	,	PUNCT
fnp-3341	176	7	lagerweij	lagerweij	PROPN
fnp-3341	176	8	t	t	PROPN
fnp-3341	176	9	,	,	PUNCT
fnp-3341	176	10	et	et	PROPN
fnp-3341	176	11	al	al	PROPN
fnp-3341	176	12	.	.	PUNCT
fnp-3341	176	13	convection	convection	NOUN
fnp-3341	176	14	enhanced	enhance	VERB
fnp-3341	176	15	delivery	delivery	NOUN
fnp-3341	176	16	of	of	ADP
fnp-3341	176	17	carmustine	carmustine	NOUN
fnp-3341	176	18	to	to	ADP
fnp-3341	176	19	the	the	DET
fnp-3341	176	20	murine	murine	ADJ
fnp-3341	176	21	brainstem	brainstem	NOUN
fnp-3341	176	22	:	:	PUNCT
fnp-3341	176	23	a	a	DET
fnp-3341	176	24	feasibility	feasibility	NOUN
fnp-3341	176	25	study	study	NOUN
fnp-3341	176	26	.	.	PUNCT
fnp-3341	177	1	j	j	PROPN
fnp-3341	177	2	neurosci	neurosci	PROPN
fnp-3341	177	3	methods	method	NOUN
fnp-3341	177	4	2014	2014	NUM
fnp-3341	177	5	;	;	PUNCT
fnp-3341	177	6	238	238	NUM
fnp-3341	177	7	:	:	SYM
fnp-3341	177	8	88	88	NUM
fnp-3341	177	9	-	-	SYM
fnp-3341	177	10	94	94	NUM
fnp-3341	177	11	.	.	PUNCT
fnp-3341	177	12	10	10	NUM
fnp-3341	177	13	.	.	X
fnp-3341	177	14	veringa	veringa	ADJ
fnp-3341	177	15	sj	sj	PROPN
fnp-3341	177	16	,	,	PUNCT
fnp-3341	177	17	biesmans	biesman	NOUN
fnp-3341	177	18	d	d	NOUN
fnp-3341	177	19	,	,	PUNCT
fnp-3341	177	20	van	van	PROPN
fnp-3341	177	21	vuurden	vuurden	NOUN
fnp-3341	177	22	dg	dg	PROPN
fnp-3341	177	23	,	,	PUNCT
fnp-3341	177	24	et	et	PROPN
fnp-3341	177	25	al	al	PROPN
fnp-3341	177	26	.	.	PROPN
fnp-3341	178	1	in	in	ADP
fnp-3341	178	2	vitro	vitro	X
fnp-3341	178	3	drug	drug	NOUN
fnp-3341	178	4	response	response	NOUN
fnp-3341	178	5	and	and	CCONJ
fnp-3341	178	6	efflux	efflux	VERB
fnp-3341	178	7	transporters	transporter	NOUN
fnp-3341	178	8	associated	associate	VERB
fnp-3341	178	9	with	with	ADP
fnp-3341	178	10	drug	drug	NOUN
fnp-3341	178	11	resistance	resistance	NOUN
fnp-3341	178	12	in	in	ADP
fnp-3341	178	13	pediatric	pediatric	ADJ
fnp-3341	178	14	high	high	ADJ
fnp-3341	178	15	grade	grade	NOUN
fnp-3341	178	16	glioma	glioma	NOUN
fnp-3341	178	17	and	and	CCONJ
fnp-3341	178	18	diffuse	diffuse	VERB
fnp-3341	178	19	intrinsic	intrinsic	ADJ
fnp-3341	178	20	pontine	pontine	ADJ
fnp-3341	178	21	glioma	glioma	NOUN
fnp-3341	178	22	.	.	PUNCT
fnp-3341	179	1	plos	plos	PROPN
fnp-3341	179	2	one	one	NUM
fnp-3341	179	3	2013	2013	NUM
fnp-3341	179	4	;	;	PUNCT
fnp-3341	179	5	8(4	8(4	NUM
fnp-3341	179	6	):	):	PUNCT
fnp-3341	179	7	e61512	e61512	NOUN
fnp-3341	179	8	.	.	PUNCT
fnp-3341	179	9	11	11	NUM
fnp-3341	179	10	.	.	PUNCT
fnp-3341	180	1	grasso	grasso	PROPN
fnp-3341	180	2	cs	cs	PROPN
fnp-3341	180	3	,	,	PUNCT
fnp-3341	180	4	tang	tang	PROPN
fnp-3341	180	5	y	y	PROPN
fnp-3341	180	6	,	,	PUNCT
fnp-3341	180	7	truffaux	truffaux	NOUN
fnp-3341	180	8	n	n	CCONJ
fnp-3341	180	9	,	,	PUNCT
fnp-3341	180	10	et	et	PROPN
fnp-3341	180	11	al	al	PROPN
fnp-3341	180	12	.	.	PUNCT
fnp-3341	181	1	functionally	functionally	ADV
fnp-3341	181	2	defined	define	VERB
fnp-3341	181	3	therapeutic	therapeutic	ADJ
fnp-3341	181	4	targets	target	NOUN
fnp-3341	181	5	in	in	ADP
fnp-3341	181	6	diffuse	diffuse	ADJ
fnp-3341	181	7	intrinsic	intrinsic	ADJ
fnp-3341	181	8	pontine	pontine	ADJ
fnp-3341	181	9	glioma	glioma	NOUN
fnp-3341	181	10	.	.	PUNCT
fnp-3341	182	1	nat	nat	PROPN
fnp-3341	182	2	med	me	VERB
fnp-3341	182	3	2015	2015	NUM
fnp-3341	182	4	;	;	PUNCT
fnp-3341	182	5	21(6	21(6	NUM
fnp-3341	182	6	):	):	PUNCT
fnp-3341	182	7	555	555	NUM
fnp-3341	182	8	-	-	SYM
fnp-3341	182	9	9	9	NUM
fnp-3341	182	10	.	.	NOUN
fnp-3341	182	11	12	12	NUM
fnp-3341	182	12	.	.	PUNCT
fnp-3341	183	1	haumann	haumann	PROPN
fnp-3341	183	2	r	r	PROPN
fnp-3341	183	3	,	,	PUNCT
fnp-3341	183	4	videira	videira	PROPN
fnp-3341	183	5	jc	jc	PROPN
fnp-3341	183	6	,	,	PUNCT
fnp-3341	183	7	kaspers	kasper	NOUN
fnp-3341	183	8	gjl	gjl	PROPN
fnp-3341	183	9	,	,	PUNCT
fnp-3341	183	10	van	van	PROPN
fnp-3341	183	11	vuurden	vuurden	NOUN
fnp-3341	183	12	dg	dg	PROPN
fnp-3341	183	13	,	,	PUNCT
fnp-3341	183	14	hulleman	hulleman	NOUN
fnp-3341	183	15	e.	e.	PROPN
fnp-3341	183	16	overview	overview	NOUN
fnp-3341	183	17	of	of	ADP
fnp-3341	183	18	current	current	ADJ
fnp-3341	183	19	drug	drug	NOUN
fnp-3341	183	20	delivery	delivery	NOUN
fnp-3341	183	21	methods	method	NOUN
fnp-3341	183	22	across	across	ADP
fnp-3341	183	23	the	the	DET
fnp-3341	183	24	blood	blood	NOUN
fnp-3341	183	25	-	-	PUNCT
fnp-3341	183	26	brain	brain	NOUN
fnp-3341	183	27	barrier	barrier	NOUN
fnp-3341	183	28	for	for	ADP
fnp-3341	183	29	the	the	DET
fnp-3341	183	30	treatment	treatment	NOUN
fnp-3341	183	31	of	of	ADP
fnp-3341	183	32	primary	primary	ADJ
fnp-3341	183	33	brain	brain	NOUN
fnp-3341	183	34	tumors	tumor	NOUN
fnp-3341	183	35	.	.	PUNCT
fnp-3341	184	1	cns	cns	NOUN
fnp-3341	184	2	drugs	drug	NOUN
fnp-3341	184	3	2020	2020	NUM
fnp-3341	184	4	;	;	PUNCT
fnp-3341	184	5	34(11	34(11	NUM
fnp-3341	184	6	):	):	PUNCT
fnp-3341	184	7	1121	1121	NUM
fnp-3341	184	8	-	-	SYM
fnp-3341	184	9	31	31	NUM
fnp-3341	184	10	.	.	PUNCT
fnp-3341	184	11	13	13	NUM
fnp-3341	184	12	.	.	X
fnp-3341	184	13	obermeier	obermeier	PROPN
fnp-3341	184	14	b	b	PROPN
fnp-3341	184	15	,	,	PUNCT
fnp-3341	184	16	daneman	daneman	NOUN
fnp-3341	184	17	r	r	NOUN
fnp-3341	184	18	,	,	PUNCT
fnp-3341	184	19	ransohoff	ransohoff	PROPN
fnp-3341	184	20	rm	rm	PROPN
fnp-3341	184	21	.	.	PUNCT
fnp-3341	184	22	development	development	PROPN
fnp-3341	184	23	,	,	PUNCT
fnp-3341	184	24	maintenance	maintenance	NOUN
fnp-3341	184	25	and	and	CCONJ
fnp-3341	184	26	disruption	disruption	NOUN
fnp-3341	184	27	of	of	ADP
fnp-3341	184	28	the	the	DET
fnp-3341	184	29	blood	blood	NOUN
fnp-3341	184	30	-	-	PUNCT
fnp-3341	184	31	brain	brain	NOUN
fnp-3341	184	32	barrier	barrier	NOUN
fnp-3341	184	33	.	.	PUNCT
fnp-3341	185	1	nat	nat	PROPN
fnp-3341	185	2	med	med	PROPN
fnp-3341	185	3	2013	2013	NUM
fnp-3341	185	4	;	;	PUNCT
fnp-3341	185	5	19(12	19(12	NUM
fnp-3341	185	6	):	):	PUNCT
fnp-3341	185	7	1584	1584	NUM
fnp-3341	185	8	-	-	SYM
fnp-3341	185	9	96	96	NUM
fnp-3341	185	10	.	.	PUNCT
fnp-3341	186	1	14	14	NUM
fnp-3341	186	2	.	.	PUNCT
fnp-3341	187	1	serlin	serlin	PROPN
fnp-3341	187	2	y	y	PROPN
fnp-3341	187	3	,	,	PUNCT
fnp-3341	187	4	shelef	shelef	PROPN
fnp-3341	187	5	i	i	PRON
fnp-3341	187	6	,	,	PUNCT
fnp-3341	187	7	knyazer	knyazer	PROPN
fnp-3341	187	8	b	b	PROPN
fnp-3341	187	9	,	,	PUNCT
fnp-3341	187	10	friedman	friedman	PROPN
fnp-3341	187	11	a.	a.	NOUN
fnp-3341	187	12	anatomy	anatomy	NOUN
fnp-3341	187	13	and	and	CCONJ
fnp-3341	187	14	physiology	physiology	NOUN
fnp-3341	187	15	of	of	ADP
fnp-3341	187	16	the	the	DET
fnp-3341	187	17	blood	blood	NOUN
fnp-3341	187	18	-	-	PUNCT
fnp-3341	187	19	brain	brain	NOUN
fnp-3341	187	20	barrier	barrier	NOUN
fnp-3341	187	21	.	.	PUNCT
fnp-3341	188	1	semin	semin	PROPN
fnp-3341	188	2	cell	cell	PROPN
fnp-3341	188	3	dev	dev	PROPN
fnp-3341	188	4	biol	biol	PROPN
fnp-3341	188	5	2015	2015	NUM
fnp-3341	188	6	;	;	PUNCT
fnp-3341	188	7	38	38	NUM
fnp-3341	188	8	:	:	SYM
fnp-3341	188	9	2	2	NUM
fnp-3341	188	10	-	-	SYM
fnp-3341	188	11	6	6	NUM
fnp-3341	188	12	.	.	NOUN
fnp-3341	188	13	15	15	NUM
fnp-3341	188	14	.	.	PUNCT
fnp-3341	189	1	abbott	abbott	PROPN
fnp-3341	189	2	nj	nj	PROPN
fnp-3341	189	3	,	,	PUNCT
fnp-3341	189	4	ronnback	ronnback	PROPN
fnp-3341	189	5	l	l	PROPN
fnp-3341	189	6	,	,	PUNCT
fnp-3341	189	7	hansson	hansson	PROPN
fnp-3341	189	8	e.	e.	PROPN
fnp-3341	189	9	astrocyte	astrocyte	PROPN
fnp-3341	189	10	-	-	PUNCT
fnp-3341	189	11	endothelial	endothelial	ADJ
fnp-3341	189	12	interactions	interaction	NOUN
fnp-3341	189	13	at	at	ADP
fnp-3341	189	14	the	the	DET
fnp-3341	189	15	blood	blood	NOUN
fnp-3341	189	16	-	-	PUNCT
fnp-3341	189	17	brain	brain	NOUN
fnp-3341	189	18	barrier	barrier	NOUN
fnp-3341	189	19	.	.	PUNCT
fnp-3341	190	1	nat	nat	PROPN
fnp-3341	190	2	rev	rev	VERB
fnp-3341	190	3	neurosci	neurosci	PROPN
fnp-3341	190	4	2006	2006	NUM
fnp-3341	190	5	;	;	PUNCT
fnp-3341	190	6	7(1	7(1	NUM
fnp-3341	190	7	):	):	PUNCT
fnp-3341	190	8	41	41	NUM
fnp-3341	190	9	-	-	SYM
fnp-3341	190	10	53	53	NUM
fnp-3341	190	11	.	.	PUNCT
fnp-3341	191	1	16	16	NUM
fnp-3341	191	2	.	.	PUNCT
fnp-3341	192	1	liebner	liebner	PROPN
fnp-3341	192	2	s	s	PROPN
fnp-3341	192	3	,	,	PUNCT
fnp-3341	192	4	dijkhuizen	dijkhuizen	ADJ
fnp-3341	192	5	rm	rm	PROPN
fnp-3341	192	6	,	,	PUNCT
fnp-3341	192	7	reiss	reiss	PROPN
fnp-3341	192	8	y	y	PROPN
fnp-3341	192	9	,	,	PUNCT
fnp-3341	192	10	plate	plate	NOUN
fnp-3341	192	11	kh	kh	PROPN
fnp-3341	192	12	,	,	PUNCT
fnp-3341	192	13	agalliu	agalliu	VERB
fnp-3341	192	14	d	d	PROPN
fnp-3341	192	15	,	,	PUNCT
fnp-3341	192	16	constantin	constantin	PROPN
fnp-3341	192	17	g.	g.	PROPN
fnp-3341	192	18	functional	functional	ADJ
fnp-3341	192	19	morphology	morphology	NOUN
fnp-3341	192	20	of	of	ADP
fnp-3341	192	21	the	the	DET
fnp-3341	192	22	blood	blood	NOUN
fnp-3341	192	23	-	-	PUNCT
fnp-3341	192	24	brain	brain	NOUN
fnp-3341	192	25	barrier	barrier	NOUN
fnp-3341	192	26	in	in	ADP
fnp-3341	192	27	health	health	NOUN
fnp-3341	192	28	and	and	CCONJ
fnp-3341	192	29	disease	disease	NOUN
fnp-3341	192	30	.	.	PUNCT
fnp-3341	193	1	acta	acta	PROPN
fnp-3341	193	2	neuropathol	neuropathol	PROPN
fnp-3341	193	3	2018	2018	NUM
fnp-3341	193	4	;	;	PUNCT
fnp-3341	193	5	135(3	135(3	NUM
fnp-3341	193	6	):	):	PUNCT
fnp-3341	193	7	311	311	NUM
fnp-3341	193	8	-	-	SYM
fnp-3341	193	9	36	36	NUM
fnp-3341	193	10	.	.	PUNCT
fnp-3341	193	11	17	17	NUM
fnp-3341	193	12	.	.	PUNCT
fnp-3341	194	1	wilhelm	wilhelm	PROPN
fnp-3341	194	2	i	i	PROPN
fnp-3341	194	3	,	,	PUNCT
fnp-3341	194	4	nyul	nyul	PROPN
fnp-3341	194	5	-	-	PUNCT
fnp-3341	194	6	toth	toth	PROPN
fnp-3341	194	7	a	a	PROPN
fnp-3341	194	8	,	,	PUNCT
fnp-3341	194	9	suciu	suciu	PROPN
fnp-3341	194	10	m	m	PROPN
fnp-3341	194	11	,	,	PUNCT
fnp-3341	194	12	hermenean	hermenean	PROPN
fnp-3341	194	13	a	a	PROPN
fnp-3341	194	14	,	,	PUNCT
fnp-3341	194	15	krizbai	krizbai	PROPN
fnp-3341	194	16	ia	ia	PROPN
fnp-3341	194	17	.	.	PROPN
fnp-3341	194	18	heterogeneity	heterogeneity	NOUN
fnp-3341	194	19	of	of	ADP
fnp-3341	194	20	the	the	DET
fnp-3341	194	21	blood	blood	NOUN
fnp-3341	194	22	-	-	PUNCT
fnp-3341	194	23	brain	brain	NOUN
fnp-3341	194	24	barrier	barrier	NOUN
fnp-3341	194	25	.	.	PUNCT
fnp-3341	195	1	tissue	tissue	NOUN
fnp-3341	195	2	barriers	barrier	NOUN
fnp-3341	195	3	2016	2016	NUM
fnp-3341	195	4	;	;	PUNCT
fnp-3341	195	5	4(1	4(1	NOUN
fnp-3341	195	6	):	):	PUNCT
fnp-3341	195	7	e1143544	e1143544	PROPN
fnp-3341	195	8	.	.	PROPN
fnp-3341	195	9	18	18	NUM
fnp-3341	195	10	.	.	X
fnp-3341	195	11	villabona	villabona	PROPN
fnp-3341	195	12	-	-	PUNCT
fnp-3341	195	13	rueda	rueda	PROPN
fnp-3341	195	14	a	a	X
fnp-3341	195	15	,	,	PUNCT
fnp-3341	195	16	erice	erice	NOUN
fnp-3341	195	17	c	c	NOUN
fnp-3341	195	18	,	,	PUNCT
fnp-3341	195	19	pardo	pardo	PROPN
fnp-3341	195	20	ca	ca	PROPN
fnp-3341	195	21	,	,	PUNCT
fnp-3341	195	22	stins	stin	NOUN
fnp-3341	195	23	mf	mf	X
fnp-3341	195	24	.	.	PUNCT
fnp-3341	196	1	the	the	DET
fnp-3341	196	2	evolving	evolve	VERB
fnp-3341	196	3	concept	concept	NOUN
fnp-3341	196	4	of	of	ADP
fnp-3341	196	5	the	the	DET
fnp-3341	196	6	blood	blood	NOUN
fnp-3341	196	7	brain	brain	NOUN
fnp-3341	196	8	barrier	barrier	NOUN
fnp-3341	196	9	(	(	PUNCT
fnp-3341	196	10	bbb	bbb	PROPN
fnp-3341	196	11	):	):	PUNCT
fnp-3341	196	12	from	from	ADP
fnp-3341	196	13	a	a	DET
fnp-3341	196	14	single	single	ADJ
fnp-3341	196	15	static	static	ADJ
fnp-3341	196	16	barrier	barrier	NOUN
fnp-3341	196	17	to	to	ADP
fnp-3341	196	18	a	a	DET
fnp-3341	196	19	heterogeneous	heterogeneous	ADJ
fnp-3341	196	20	and	and	CCONJ
fnp-3341	196	21	dynamic	dynamic	ADJ
fnp-3341	196	22	relay	relay	NOUN
fnp-3341	196	23	center	center	NOUN
fnp-3341	196	24	.	.	PUNCT
fnp-3341	197	1	front	front	ADJ
fnp-3341	197	2	cell	cell	NOUN
fnp-3341	197	3	neurosci	neurosci	NOUN
fnp-3341	197	4	2019	2019	NUM
fnp-3341	197	5	;	;	PUNCT
fnp-3341	197	6	13	13	NUM
fnp-3341	197	7	:	:	SYM
fnp-3341	197	8	405	405	NUM
fnp-3341	197	9	.	.	NOUN
fnp-3341	197	10	19	19	NUM
fnp-3341	197	11	.	.	X
fnp-3341	197	12	caretti	caretti	PROPN
fnp-3341	197	13	v	v	PROPN
fnp-3341	197	14	,	,	PUNCT
fnp-3341	197	15	jansen	jansen	PROPN
fnp-3341	197	16	mh	mh	PROPN
fnp-3341	197	17	,	,	PUNCT
fnp-3341	197	18	van	van	PROPN
fnp-3341	197	19	vuurden	vuurden	PROPN
fnp-3341	197	20	dg	dg	PROPN
fnp-3341	197	21	,	,	PUNCT
fnp-3341	197	22	et	et	PROPN
fnp-3341	197	23	al	al	PROPN
fnp-3341	197	24	.	.	PUNCT
fnp-3341	197	25	implementation	implementation	NOUN
fnp-3341	197	26	of	of	ADP
fnp-3341	197	27	a	a	DET
fnp-3341	197	28	multi	multi	ADJ
fnp-3341	197	29	-	-	ADJ
fnp-3341	197	30	institutional	institutional	ADJ
fnp-3341	197	31	diffuse	diffuse	NOUN
fnp-3341	197	32	intrinsic	intrinsic	ADJ
fnp-3341	197	33	pontine	pontine	ADJ
fnp-3341	197	34	glioma	glioma	ADJ
fnp-3341	197	35	autopsy	autopsy	ADJ
fnp-3341	197	36	protocol	protocol	NOUN
fnp-3341	197	37	and	and	CCONJ
fnp-3341	197	38	characterization	characterization	NOUN
fnp-3341	197	39	of	of	ADP
fnp-3341	197	40	a	a	DET
fnp-3341	197	41	primary	primary	ADJ
fnp-3341	197	42	cell	cell	NOUN
fnp-3341	197	43	culture	culture	NOUN
fnp-3341	197	44	.	.	PUNCT
fnp-3341	198	1	neuropathol	neuropathol	PROPN
fnp-3341	198	2	appl	appl	PROPN
fnp-3341	198	3	neurobiol	neurobiol	PROPN
fnp-3341	198	4	2013	2013	NUM
fnp-3341	198	5	;	;	PUNCT
fnp-3341	198	6	39(4	39(4	NUM
fnp-3341	198	7	):	):	PUNCT
fnp-3341	198	8	426	426	NUM
fnp-3341	198	9	-	-	SYM
fnp-3341	198	10	36	36	NUM
fnp-3341	198	11	.	.	PUNCT
fnp-3341	198	12	20	20	NUM
fnp-3341	198	13	.	.	PUNCT
fnp-3341	199	1	bugiani	bugiani	PROPN
fnp-3341	199	2	m	m	PROPN
fnp-3341	199	3	,	,	PUNCT
fnp-3341	199	4	veldhuijzen	veldhuijzen	PROPN
fnp-3341	199	5	van	van	PROPN
fnp-3341	199	6	zanten	zanten	PROPN
fnp-3341	199	7	sem	sem	PROPN
fnp-3341	199	8	,	,	PUNCT
fnp-3341	199	9	caretti	caretti	ADJ
fnp-3341	199	10	v	v	NOUN
fnp-3341	199	11	,	,	PUNCT
fnp-3341	199	12	et	et	PROPN
fnp-3341	199	13	al	al	PROPN
fnp-3341	199	14	.	.	PROPN
fnp-3341	200	1	deceptive	deceptive	ADJ
fnp-3341	200	2	morphologic	morphologic	ADJ
fnp-3341	200	3	and	and	CCONJ
fnp-3341	200	4	epigenetic	epigenetic	ADJ
fnp-3341	200	5	heterogeneity	heterogeneity	NOUN
fnp-3341	200	6	in	in	ADP
fnp-3341	200	7	diffuse	diffuse	NOUN
fnp-3341	200	8	intrinsic	intrinsic	ADJ
fnp-3341	200	9	pontine	pontine	ADJ
fnp-3341	200	10	glioma	glioma	NOUN
fnp-3341	200	11	.	.	PUNCT
fnp-3341	201	1	oncotarget	oncotarget	NOUN
fnp-3341	201	2	2017	2017	NUM
fnp-3341	201	3	;	;	PUNCT
fnp-3341	201	4	8(36	8(36	NUM
fnp-3341	201	5	):	):	PUNCT
fnp-3341	201	6	60447	60447	NUM
fnp-3341	201	7	-	-	SYM
fnp-3341	201	8	52	52	NUM
fnp-3341	201	9	.	.	PUNCT
fnp-3341	201	10	21	21	NUM
fnp-3341	201	11	.	.	PUNCT
fnp-3341	202	1	castel	castel	PROPN
fnp-3341	202	2	d	d	PROPN
fnp-3341	202	3	,	,	PUNCT
fnp-3341	202	4	philippe	philippe	PROPN
fnp-3341	202	5	c	c	PROPN
fnp-3341	202	6	,	,	PUNCT
fnp-3341	202	7	calmon	calmon	ADJ
fnp-3341	202	8	r	r	NOUN
fnp-3341	202	9	,	,	PUNCT
fnp-3341	202	10	et	et	PROPN
fnp-3341	202	11	al	al	PROPN
fnp-3341	202	12	.	.	PUNCT
fnp-3341	203	1	histone	histone	PROPN
fnp-3341	203	2	h3f3a	h3f3a	PUNCT
fnp-3341	203	3	and	and	CCONJ
fnp-3341	203	4	hist1h3b	hist1h3b	PRON
fnp-3341	203	5	k27	k27	PROPN
fnp-3341	203	6	m	m	PROPN
fnp-3341	203	7	mutations	mutation	NOUN
fnp-3341	203	8	define	define	VERB
fnp-3341	203	9	two	two	NUM
fnp-3341	203	10	subgroups	subgroup	NOUN
fnp-3341	203	11	of	of	ADP
fnp-3341	203	12	diffuse	diffuse	NOUN
fnp-3341	203	13	intrinsic	intrinsic	ADJ
fnp-3341	203	14	pontine	pontine	ADJ
fnp-3341	203	15	gliomas	glioma	NOUN
fnp-3341	203	16	with	with	ADP
fnp-3341	203	17	different	different	ADJ
fnp-3341	203	18	prognosis	prognosis	NOUN
fnp-3341	203	19	and	and	CCONJ
fnp-3341	203	20	phenotypes	phenotype	NOUN
fnp-3341	203	21	.	.	PUNCT
fnp-3341	204	1	acta	acta	PROPN
fnp-3341	204	2	neuropathol	neuropathol	PROPN
fnp-3341	204	3	2015	2015	NUM
fnp-3341	204	4	;	;	PUNCT
fnp-3341	204	5	130(6	130(6	NUM
fnp-3341	204	6	):	):	PUNCT
fnp-3341	204	7	815	815	NUM
fnp-3341	204	8	-	-	SYM
fnp-3341	204	9	27	27	NUM
fnp-3341	204	10	.	.	PUNCT
fnp-3341	205	1	22	22	NUM
fnp-3341	205	2	.	.	PUNCT
fnp-3341	206	1	karremann	karremann	PROPN
fnp-3341	206	2	m	m	PROPN
fnp-3341	206	3	,	,	PUNCT
fnp-3341	206	4	gielen	gielen	PROPN
fnp-3341	206	5	gh	gh	PROPN
fnp-3341	206	6	,	,	PUNCT
fnp-3341	206	7	hoffmann	hoffmann	PROPN
fnp-3341	206	8	m	m	PROPN
fnp-3341	206	9	,	,	PUNCT
fnp-3341	206	10	et	et	PROPN
fnp-3341	206	11	al	al	PROPN
fnp-3341	206	12	.	.	PUNCT
fnp-3341	207	1	diffuse	diffuse	VERB
fnp-3341	207	2	high	high	ADJ
fnp-3341	207	3	-	-	PUNCT
fnp-3341	207	4	grade	grade	NOUN
fnp-3341	207	5	gliomas	glioma	NOUN
fnp-3341	207	6	with	with	ADP
fnp-3341	207	7	h3	h3	NOUN
fnp-3341	207	8	k27	k27	PROPN
fnp-3341	207	9	m	m	PROPN
fnp-3341	207	10	mutations	mutation	NOUN
fnp-3341	207	11	carry	carry	VERB
fnp-3341	207	12	a	a	DET
fnp-3341	207	13	dismal	dismal	ADJ
fnp-3341	207	14	prognosis	prognosis	NOUN
fnp-3341	207	15	independent	independent	NOUN
fnp-3341	207	16	of	of	ADP
fnp-3341	207	17	tumor	tumor	NOUN
fnp-3341	207	18	location	location	NOUN
fnp-3341	207	19	.	.	PUNCT
fnp-3341	208	1	neuro	neuro	PROPN
fnp-3341	208	2	oncol	oncol	ADJ
fnp-3341	208	3	2018	2018	NUM
fnp-3341	208	4	;	;	PUNCT
fnp-3341	209	1	20(1	20(1	NUM
fnp-3341	209	2	):	):	PUNCT
fnp-3341	209	3	123	123	NUM
fnp-3341	209	4	-	-	SYM
fnp-3341	209	5	31	31	NUM
fnp-3341	209	6	.	.	PUNCT
fnp-3341	210	1	23	23	NUM
fnp-3341	210	2	.	.	PUNCT
fnp-3341	211	1	wagner	wagner	PROPN
fnp-3341	211	2	s	s	PROPN
fnp-3341	211	3	,	,	PUNCT
fnp-3341	211	4	warmuth	warmuth	NOUN
fnp-3341	211	5	-	-	PUNCT
fnp-3341	211	6	metz	metz	PROPN
fnp-3341	211	7	m	m	PROPN
fnp-3341	211	8	,	,	PUNCT
fnp-3341	211	9	emser	emser	VERB
fnp-3341	211	10	a	a	NOUN
fnp-3341	211	11	,	,	PUNCT
fnp-3341	211	12	et	et	PROPN
fnp-3341	211	13	al	al	PROPN
fnp-3341	211	14	.	.	PUNCT
fnp-3341	211	15	treatment	treatment	NOUN
fnp-3341	211	16	options	option	NOUN
fnp-3341	211	17	in	in	ADP
fnp-3341	211	18	childhood	childhood	NOUN
fnp-3341	211	19	pontine	pontine	NOUN
fnp-3341	211	20	gliomas	glioma	NOUN
fnp-3341	211	21	.	.	PUNCT
fnp-3341	212	1	j	j	PROPN
fnp-3341	212	2	neurooncol	neurooncol	PROPN
fnp-3341	212	3	2006	2006	NUM
fnp-3341	212	4	;	;	PUNCT
fnp-3341	212	5	79(3	79(3	NUM
fnp-3341	212	6	):	):	PUNCT
fnp-3341	212	7	281	281	NUM
fnp-3341	212	8	-	-	SYM
fnp-3341	212	9	7	7	NUM
fnp-3341	212	10	.	.	NUM
fnp-3341	212	11	24	24	NUM
fnp-3341	212	12	.	.	PUNCT
fnp-3341	213	1	von	von	PROPN
fnp-3341	213	2	bueren	bueren	PROPN
fnp-3341	213	3	ao	ao	PROPN
fnp-3341	213	4	,	,	PUNCT
fnp-3341	213	5	karremann	karremann	PROPN
fnp-3341	213	6	m	m	PRON
fnp-3341	213	7	,	,	PUNCT
fnp-3341	213	8	gielen	gielen	PROPN
fnp-3341	213	9	gh	gh	PROPN
fnp-3341	213	10	,	,	PUNCT
fnp-3341	213	11	et	et	PROPN
fnp-3341	213	12	al	al	PROPN
fnp-3341	213	13	.	.	PUNCT
fnp-3341	214	1	a	a	DET
fnp-3341	214	2	suggestion	suggestion	NOUN
fnp-3341	214	3	to	to	PART
fnp-3341	214	4	introduce	introduce	VERB
fnp-3341	214	5	the	the	DET
fnp-3341	214	6	diagnosis	diagnosis	NOUN
fnp-3341	214	7	of	of	ADP
fnp-3341	214	8	"	"	PUNCT
fnp-3341	214	9	diffuse	diffuse	VERB
fnp-3341	214	10	midline	midline	NOUN
fnp-3341	214	11	glioma	glioma	NOUN
fnp-3341	214	12	of	of	ADP
fnp-3341	214	13	the	the	DET
fnp-3341	214	14	pons	pon	NOUN
fnp-3341	214	15	,	,	PUNCT
fnp-3341	214	16	h3	h3	VERB
fnp-3341	214	17	k27	k27	PROPN
fnp-3341	214	18	wildtype	wildtype	NOUN
fnp-3341	214	19	(	(	PUNCT
fnp-3341	214	20	who	who	PRON
fnp-3341	214	21	grade	grade	VERB
fnp-3341	214	22	iv	iv	NUM
fnp-3341	214	23	)	)	PUNCT
fnp-3341	214	24	"	"	PUNCT
fnp-3341	214	25	.	.	PUNCT
fnp-3341	215	1	acta	acta	PROPN
fnp-3341	215	2	neuropathol	neuropathol	PROPN
fnp-3341	215	3	2018	2018	NUM
fnp-3341	215	4	;	;	PUNCT
fnp-3341	215	5	136(1	136(1	NUM
fnp-3341	215	6	):	):	PUNCT
fnp-3341	215	7	171	171	NUM
fnp-3341	215	8	-	-	SYM
fnp-3341	215	9	3	3	NUM
fnp-3341	215	10	.	.	NUM
fnp-3341	215	11	25	25	NUM
fnp-3341	215	12	.	.	PUNCT
fnp-3341	216	1	greene	greene	PROPN
fnp-3341	216	2	c	c	PROPN
fnp-3341	216	3	,	,	PUNCT
fnp-3341	216	4	hanley	hanley	PROPN
fnp-3341	216	5	n	n	CCONJ
fnp-3341	216	6	,	,	PUNCT
fnp-3341	216	7	campbell	campbell	PROPN
fnp-3341	216	8	m.	m.	NOUN
fnp-3341	217	1	claudin-5	claudin-5	NOUN
fnp-3341	217	2	:	:	PUNCT
fnp-3341	217	3	gatekeeper	gatekeeper	NOUN
fnp-3341	217	4	of	of	ADP
fnp-3341	217	5	neurological	neurological	ADJ
fnp-3341	217	6	function	function	NOUN
fnp-3341	217	7	.	.	PUNCT
fnp-3341	218	1	fluids	fluid	NOUN
fnp-3341	218	2	barriers	barrier	NOUN
fnp-3341	218	3	cns	cns	PROPN
fnp-3341	218	4	2019	2019	NUM
fnp-3341	218	5	;	;	PUNCT
fnp-3341	218	6	16(1	16(1	NUM
fnp-3341	218	7	):	):	PUNCT
fnp-3341	218	8	3	3	NUM
fnp-3341	218	9	.	.	NOUN
fnp-3341	218	10	26	26	NUM
fnp-3341	218	11	.	.	PUNCT
fnp-3341	219	1	jia	jia	PROPN
fnp-3341	219	2	w	w	PROPN
fnp-3341	219	3	,	,	PUNCT
fnp-3341	219	4	lu	lu	PROPN
fnp-3341	219	5	r	r	PROPN
fnp-3341	219	6	,	,	PUNCT
fnp-3341	219	7	martin	martin	PROPN
fnp-3341	219	8	ta	ta	PROPN
fnp-3341	219	9	,	,	PUNCT
fnp-3341	219	10	jiang	jiang	PROPN
fnp-3341	219	11	wg	wg	PROPN
fnp-3341	219	12	.	.	PUNCT
fnp-3341	220	1	the	the	DET
fnp-3341	220	2	role	role	NOUN
fnp-3341	220	3	of	of	ADP
fnp-3341	220	4	claudin-5	claudin-5	NUM
fnp-3341	220	5	in	in	ADP
fnp-3341	220	6	blood	blood	NOUN
fnp-3341	220	7	-	-	PUNCT
fnp-3341	220	8	brain	brain	NOUN
fnp-3341	220	9	barrier	barrier	NOUN
fnp-3341	220	10	(	(	PUNCT
fnp-3341	220	11	bbb	bbb	NOUN
fnp-3341	220	12	)	)	PUNCT
fnp-3341	220	13	and	and	CCONJ
fnp-3341	220	14	brain	brain	NOUN
fnp-3341	220	15	metastases	metastasis	NOUN
fnp-3341	220	16	(	(	PUNCT
fnp-3341	220	17	review	review	NOUN
fnp-3341	220	18	)	)	PUNCT
fnp-3341	220	19	.	.	PUNCT
fnp-3341	221	1	mol	mol	ADP
fnp-3341	221	2	med	med	PROPN
fnp-3341	221	3	rep	rep	PROPN
fnp-3341	221	4	2014	2014	NUM
fnp-3341	221	5	;	;	PUNCT
fnp-3341	221	6	9(3	9(3	NUM
fnp-3341	221	7	):	):	PUNCT
fnp-3341	221	8	779	779	NUM
fnp-3341	221	9	-	-	SYM
fnp-3341	221	10	85	85	NUM
fnp-3341	221	11	.	.	PUNCT
fnp-3341	221	12	27	27	NUM
fnp-3341	221	13	.	.	PUNCT
fnp-3341	222	1	tornavaca	tornavaca	PROPN
fnp-3341	222	2	o	o	NOUN
fnp-3341	222	3	,	,	PUNCT
fnp-3341	222	4	chia	chia	PROPN
fnp-3341	222	5	m	m	PROPN
fnp-3341	222	6	,	,	PUNCT
fnp-3341	222	7	dufton	dufton	NOUN
fnp-3341	222	8	n	n	CCONJ
fnp-3341	222	9	,	,	PUNCT
fnp-3341	222	10	et	et	PROPN
fnp-3341	222	11	al	al	PROPN
fnp-3341	222	12	.	.	PROPN
fnp-3341	222	13	zo-1	zo-1	PROPN
fnp-3341	222	14	controls	control	VERB
fnp-3341	222	15	endothelial	endothelial	ADJ
fnp-3341	222	16	adherens	adheren	NOUN
fnp-3341	222	17	junctions	junction	NOUN
fnp-3341	222	18	,	,	PUNCT
fnp-3341	222	19	cell	cell	NOUN
fnp-3341	222	20	-	-	PUNCT
fnp-3341	222	21	cell	cell	NOUN
fnp-3341	222	22	tension	tension	NOUN
fnp-3341	222	23	,	,	PUNCT
fnp-3341	222	24	angiogenesis	angiogenesis	NOUN
fnp-3341	222	25	,	,	PUNCT
fnp-3341	222	26	and	and	CCONJ
fnp-3341	222	27	barrier	barrier	NOUN
fnp-3341	222	28	formation	formation	NOUN
fnp-3341	222	29	.	.	PUNCT
fnp-3341	223	1	j	j	PROPN
fnp-3341	223	2	cell	cell	NOUN
fnp-3341	223	3	biol	biol	PROPN
fnp-3341	223	4	2015	2015	NUM
fnp-3341	223	5	;	;	PUNCT
fnp-3341	223	6	208(6	208(6	NUM
fnp-3341	223	7	):	):	PUNCT
fnp-3341	223	8	821	821	NUM
fnp-3341	223	9	-	-	SYM
fnp-3341	223	10	38	38	NUM
fnp-3341	223	11	.	.	PUNCT
fnp-3341	223	12	28	28	NUM
fnp-3341	223	13	.	.	PUNCT
fnp-3341	224	1	paul	paul	PROPN
fnp-3341	224	2	d	d	PROPN
fnp-3341	224	3	,	,	PUNCT
fnp-3341	224	4	cowan	cowan	PROPN
fnp-3341	224	5	ae	ae	PROPN
fnp-3341	224	6	,	,	PUNCT
fnp-3341	224	7	ge	ge	PROPN
fnp-3341	224	8	s	s	PROPN
fnp-3341	224	9	,	,	PUNCT
fnp-3341	224	10	pachter	pachter	PROPN
fnp-3341	224	11	js	js	PROPN
fnp-3341	224	12	.	.	PUNCT
fnp-3341	225	1	novel	novel	ADJ
fnp-3341	225	2	3d	3d	NUM
fnp-3341	225	3	analysis	analysis	NOUN
fnp-3341	225	4	of	of	ADP
fnp-3341	225	5	claudin-5	claudin-5	PRON
fnp-3341	225	6	reveals	reveal	VERB
fnp-3341	225	7	significant	significant	ADJ
fnp-3341	225	8	endothelial	endothelial	ADJ
fnp-3341	225	9	heterogeneity	heterogeneity	NOUN
fnp-3341	225	10	among	among	ADP
fnp-3341	225	11	cns	cns	NOUN
fnp-3341	225	12	microvessels	microvessel	NOUN
fnp-3341	225	13	.	.	PUNCT
fnp-3341	226	1	microvasc	microvasc	PROPN
fnp-3341	226	2	res	re	NOUN
fnp-3341	226	3	2013	2013	NUM
fnp-3341	226	4	;	;	PUNCT
fnp-3341	226	5	86	86	NUM
fnp-3341	226	6	:	:	SYM
fnp-3341	226	7	1	1	NUM
fnp-3341	226	8	-	-	SYM
fnp-3341	226	9	10	10	NUM
fnp-3341	226	10	.	.	PUNCT
fnp-3341	226	11	29	29	NUM
fnp-3341	226	12	.	.	PUNCT
fnp-3341	227	1	nitta	nitta	PROPN
fnp-3341	227	2	t	t	PROPN
fnp-3341	227	3	,	,	PUNCT
fnp-3341	227	4	hata	hata	NOUN
fnp-3341	227	5	m	m	PROPN
fnp-3341	227	6	,	,	PUNCT
fnp-3341	227	7	gotoh	gotoh	PROPN
fnp-3341	227	8	s	s	PROPN
fnp-3341	227	9	,	,	PUNCT
fnp-3341	227	10	et	et	PROPN
fnp-3341	227	11	al	al	PROPN
fnp-3341	227	12	.	.	PROPN
fnp-3341	227	13	size	size	NOUN
fnp-3341	227	14	-	-	PUNCT
fnp-3341	227	15	selective	selective	ADJ
fnp-3341	227	16	loosening	loosening	NOUN
fnp-3341	227	17	of	of	ADP
fnp-3341	227	18	the	the	DET
fnp-3341	227	19	blood	blood	NOUN
fnp-3341	227	20	-	-	PUNCT
fnp-3341	227	21	brain	brain	NOUN
fnp-3341	227	22	barrier	barrier	NOUN
fnp-3341	227	23	in	in	ADP
fnp-3341	227	24	claudin-5	claudin-5	NOUN
fnp-3341	227	25	-	-	PUNCT
fnp-3341	227	26	deficient	deficient	ADJ
fnp-3341	227	27	mice	mouse	NOUN
fnp-3341	227	28	.	.	PUNCT
fnp-3341	228	1	j	j	PROPN
fnp-3341	228	2	cell	cell	NOUN
fnp-3341	228	3	biol	biol	PROPN
fnp-3341	228	4	2003	2003	NUM
fnp-3341	228	5	;	;	PUNCT
fnp-3341	228	6	161(3	161(3	NUM
fnp-3341	228	7	):	):	PUNCT
fnp-3341	228	8	653	653	NUM
fnp-3341	228	9	-	-	SYM
fnp-3341	228	10	60	60	NUM
fnp-3341	228	11	.	.	PUNCT
fnp-3341	228	12	30	30	NUM
fnp-3341	228	13	.	.	PUNCT
fnp-3341	229	1	el	el	PROPN
fnp-3341	229	2	-	-	PUNCT
fnp-3341	229	3	khouly	khouly	PROPN
fnp-3341	229	4	fe	fe	PROPN
fnp-3341	229	5	,	,	PUNCT
fnp-3341	229	6	van	van	PROPN
fnp-3341	229	7	vuurden	vuurden	PROPN
fnp-3341	229	8	dg	dg	PROPN
fnp-3341	229	9	,	,	PUNCT
fnp-3341	229	10	stroink	stroink	PROPN
fnp-3341	229	11	t	t	PROPN
fnp-3341	229	12	,	,	PUNCT
fnp-3341	229	13	et	et	PROPN
fnp-3341	229	14	al	al	PROPN
fnp-3341	229	15	.	.	PROPN
fnp-3341	229	16	effective	effective	ADJ
fnp-3341	229	17	drug	drug	NOUN
fnp-3341	229	18	delivery	delivery	NOUN
fnp-3341	229	19	in	in	ADP
fnp-3341	229	20	diffuse	diffuse	NOUN
fnp-3341	229	21	intrinsic	intrinsic	ADJ
fnp-3341	229	22	pontine	pontine	ADJ
fnp-3341	229	23	glioma	glioma	NOUN
fnp-3341	229	24	:	:	PUNCT
fnp-3341	229	25	a	a	DET
fnp-3341	229	26	theoretical	theoretical	ADJ
fnp-3341	229	27	model	model	NOUN
fnp-3341	229	28	to	to	PART
fnp-3341	229	29	identify	identify	VERB
fnp-3341	229	30	potential	potential	ADJ
fnp-3341	229	31	candidates	candidate	NOUN
fnp-3341	229	32	.	.	PUNCT
fnp-3341	230	1	front	front	ADJ
fnp-3341	230	2	oncol	oncol	ADJ
fnp-3341	230	3	2017	2017	NUM
fnp-3341	230	4	;	;	PUNCT
fnp-3341	230	5	7	7	NUM
fnp-3341	230	6	:	:	SYM
fnp-3341	230	7	254	254	NUM
fnp-3341	230	8	.	.	X
fnp-3341	231	1	31	31	NUM
fnp-3341	231	2	.	.	PUNCT
fnp-3341	232	1	pike	pike	PROPN
fnp-3341	232	2	vw	vw	PROPN
fnp-3341	232	3	.	.	PUNCT
fnp-3341	232	4	pet	pet	ADJ
fnp-3341	232	5	radiotracers	radiotracer	NOUN
fnp-3341	232	6	:	:	PUNCT
fnp-3341	232	7	crossing	cross	VERB
fnp-3341	232	8	the	the	DET
fnp-3341	232	9	blood	blood	NOUN
fnp-3341	232	10	-	-	PUNCT
fnp-3341	232	11	brain	brain	NOUN
fnp-3341	232	12	barrier	barrier	NOUN
fnp-3341	232	13	and	and	CCONJ
fnp-3341	232	14	surviving	survive	VERB
fnp-3341	232	15	metabolism	metabolism	NOUN
fnp-3341	232	16	.	.	PUNCT
fnp-3341	233	1	trends	trend	NOUN
fnp-3341	233	2	in	in	ADP
fnp-3341	233	3	pharmacological	pharmacological	ADJ
fnp-3341	233	4	sciences	science	NOUN
fnp-3341	233	5	2009	2009	NUM
fnp-3341	233	6	;	;	PUNCT
fnp-3341	233	7	30(8	30(8	NUM
fnp-3341	233	8	):	):	PUNCT
fnp-3341	233	9	431	431	NUM
fnp-3341	233	10	-	-	SYM
fnp-3341	233	11	40	40	NUM
fnp-3341	233	12	.	.	PUNCT
fnp-3341	234	1	32	32	NUM
fnp-3341	234	2	.	.	PUNCT
fnp-3341	235	1	keaney	keaney	PROPN
fnp-3341	235	2	j	j	PROPN
fnp-3341	235	3	,	,	PUNCT
fnp-3341	235	4	walsh	walsh	PROPN
fnp-3341	235	5	dm	dm	PROPN
fnp-3341	235	6	,	,	PUNCT
fnp-3341	235	7	o’malley	o’malley	PROPN
fnp-3341	235	8	t	t	PROPN
fnp-3341	235	9	,	,	PUNCT
fnp-3341	235	10	et	et	PROPN
fnp-3341	235	11	al	al	PROPN
fnp-3341	235	12	.	.	PROPN
fnp-3341	235	13	autoregulated	autoregulate	VERB
fnp-3341	235	14	paracellular	paracellular	ADJ
fnp-3341	235	15	clearance	clearance	NOUN
fnp-3341	235	16	of	of	ADP
fnp-3341	235	17	amyloid	amyloid	NOUN
fnp-3341	235	18	-	-	PUNCT
fnp-3341	235	19	β	β	NOUN
fnp-3341	235	20	across	across	ADP
fnp-3341	235	21	the	the	DET
fnp-3341	235	22	blood	blood	NOUN
fnp-3341	235	23	-	-	PUNCT
fnp-3341	235	24	brain	brain	NOUN
fnp-3341	235	25	barrier	barrier	NOUN
fnp-3341	235	26	.	.	PUNCT
fnp-3341	236	1	science	science	NOUN
fnp-3341	236	2	advances	advance	VERB
fnp-3341	236	3	2015	2015	NUM
fnp-3341	236	4	;	;	PUNCT
fnp-3341	236	5	1(8	1(8	NUM
fnp-3341	236	6	):	):	PUNCT
fnp-3341	236	7	e1500472	e1500472	NOUN
fnp-3341	236	8	.	.	NOUN
fnp-3341	237	1	33	33	NUM
fnp-3341	237	2	.	.	PUNCT
fnp-3341	238	1	gautam	gautam	PROPN
fnp-3341	238	2	j	j	PROPN
fnp-3341	238	3	,	,	PUNCT
fnp-3341	238	4	zhang	zhang	PROPN
fnp-3341	238	5	x	x	PROPN
fnp-3341	238	6	,	,	PUNCT
fnp-3341	238	7	yao	yao	PROPN
fnp-3341	238	8	y.	y.	PROPN
fnp-3341	238	9	the	the	DET
fnp-3341	238	10	role	role	NOUN
fnp-3341	238	11	of	of	ADP
fnp-3341	238	12	pericytic	pericytic	ADJ
fnp-3341	238	13	laminin	laminin	NOUN
fnp-3341	238	14	in	in	ADP
fnp-3341	238	15	blood	blood	NOUN
fnp-3341	238	16	brain	brain	NOUN
fnp-3341	238	17	barrier	barrier	NOUN
fnp-3341	238	18	integrity	integrity	NOUN
fnp-3341	238	19	maintenance	maintenance	NOUN
fnp-3341	238	20	.	.	PUNCT
fnp-3341	239	1	sci	sci	PROPN
fnp-3341	239	2	rep	rep	PROPN
fnp-3341	239	3	2016	2016	NUM
fnp-3341	239	4	;	;	PUNCT
fnp-3341	239	5	6	6	NUM
fnp-3341	239	6	:	:	SYM
fnp-3341	239	7	36450	36450	NUM
fnp-3341	239	8	.	.	PUNCT
fnp-3341	240	1	34	34	NUM
fnp-3341	240	2	.	.	PUNCT
fnp-3341	241	1	yao	yao	PROPN
fnp-3341	241	2	y	y	PROPN
fnp-3341	241	3	,	,	PUNCT
fnp-3341	241	4	chen	chen	PROPN
fnp-3341	241	5	zl	zl	PROPN
fnp-3341	241	6	,	,	PUNCT
fnp-3341	241	7	norris	norris	PROPN
fnp-3341	241	8	eh	eh	PROPN
fnp-3341	241	9	,	,	PUNCT
fnp-3341	241	10	strickland	strickland	PROPN
fnp-3341	241	11	s.	s.	PROPN
fnp-3341	241	12	astrocytic	astrocytic	PROPN
fnp-3341	241	13	laminin	laminin	NOUN
fnp-3341	241	14	regulates	regulate	VERB
fnp-3341	241	15	pericyte	pericyte	NOUN
fnp-3341	241	16	differentiation	differentiation	NOUN
fnp-3341	241	17	and	and	CCONJ
fnp-3341	241	18	maintains	maintain	VERB
fnp-3341	241	19	blood	blood	NOUN
fnp-3341	241	20	brain	brain	NOUN
fnp-3341	241	21	barrier	barrier	NOUN
fnp-3341	241	22	integrity	integrity	NOUN
fnp-3341	241	23	.	.	PUNCT
fnp-3341	242	1	nat	nat	PROPN
fnp-3341	242	2	commun	commun	PROPN
fnp-3341	242	3	2014	2014	NUM
fnp-3341	242	4	;	;	PUNCT
fnp-3341	242	5	5	5	NUM
fnp-3341	242	6	:	:	SYM
fnp-3341	242	7	3413	3413	NUM
fnp-3341	242	8	.	.	PUNCT
fnp-3341	243	1	35	35	NUM
fnp-3341	243	2	.	.	PUNCT
fnp-3341	244	1	givant	givant	PROPN
fnp-3341	244	2	-	-	PUNCT
fnp-3341	244	3	horwitz	horwitz	PROPN
fnp-3341	244	4	v	v	PROPN
fnp-3341	244	5	,	,	PUNCT
fnp-3341	244	6	davidson	davidson	PROPN
fnp-3341	244	7	b	b	PROPN
fnp-3341	244	8	,	,	PUNCT
fnp-3341	244	9	reich	reich	PROPN
fnp-3341	244	10	r.	r.	PROPN
fnp-3341	244	11	laminin	laminin	NOUN
fnp-3341	244	12	-	-	PUNCT
fnp-3341	244	13	induced	induce	VERB
fnp-3341	244	14	signaling	signal	VERB
fnp-3341	244	15	in	in	ADP
fnp-3341	244	16	tumor	tumor	NOUN
fnp-3341	244	17	cells	cell	NOUN
fnp-3341	244	18	.	.	PUNCT
fnp-3341	245	1	cancer	cancer	NOUN
fnp-3341	245	2	lett	lett	PROPN
fnp-3341	245	3	2005	2005	NUM
fnp-3341	245	4	;	;	PUNCT
fnp-3341	245	5	223(1	223(1	NUM
fnp-3341	245	6	):	):	PUNCT
fnp-3341	245	7	1	1	NUM
fnp-3341	245	8	-	-	SYM
fnp-3341	245	9	10	10	NUM
fnp-3341	245	10	.	.	PUNCT
fnp-3341	245	11	36	36	NUM
fnp-3341	245	12	.	.	PUNCT
fnp-3341	246	1	al	al	PROPN
fnp-3341	246	2	-	-	PUNCT
fnp-3341	246	3	majdoub	majdoub	PROPN
fnp-3341	246	4	zm	zm	PROPN
fnp-3341	246	5	,	,	PUNCT
fnp-3341	246	6	al	al	PROPN
fnp-3341	246	7	feteisi	feteisi	PROPN
fnp-3341	246	8	h	h	NOUN
fnp-3341	246	9	,	,	PUNCT
fnp-3341	246	10	achour	achour	PROPN
fnp-3341	246	11	b	b	PROPN
fnp-3341	246	12	,	,	PUNCT
fnp-3341	246	13	et	et	PROPN
fnp-3341	246	14	al	al	PROPN
fnp-3341	246	15	.	.	PROPN
fnp-3341	247	1	proteomic	proteomic	ADJ
fnp-3341	247	2	quantification	quantification	NOUN
fnp-3341	247	3	of	of	ADP
fnp-3341	247	4	human	human	ADJ
fnp-3341	247	5	blood	blood	NOUN
fnp-3341	247	6	-	-	PUNCT
fnp-3341	247	7	brain	brain	NOUN
fnp-3341	247	8	barrier	barrier	NOUN
fnp-3341	247	9	slc	slc	PROPN
fnp-3341	247	10	and	and	CCONJ
fnp-3341	247	11	abc	abc	PROPN
fnp-3341	247	12	transporters	transporter	NOUN
fnp-3341	247	13	in	in	ADP
fnp-3341	247	14	healthy	healthy	ADJ
fnp-3341	247	15	individuals	individual	NOUN
fnp-3341	247	16	and	and	CCONJ
fnp-3341	247	17	dementia	dementia	NOUN
fnp-3341	247	18	patients	patient	NOUN
fnp-3341	247	19	.	.	PUNCT
fnp-3341	248	1	mol	mol	ADP
fnp-3341	248	2	pharm	pharm	NOUN
fnp-3341	248	3	2019	2019	NUM
fnp-3341	248	4	;	;	PUNCT
fnp-3341	248	5	16(3	16(3	NUM
fnp-3341	248	6	):	):	PUNCT
fnp-3341	248	7	1220	1220	NUM
fnp-3341	248	8	-	-	SYM
fnp-3341	248	9	33	33	NUM
fnp-3341	248	10	.	.	PUNCT
fnp-3341	248	11	37	37	NUM
fnp-3341	248	12	.	.	PUNCT
fnp-3341	249	1	uchida	uchida	PROPN
fnp-3341	249	2	y	y	PROPN
fnp-3341	249	3	,	,	PUNCT
fnp-3341	249	4	ohtsuki	ohtsuki	PROPN
fnp-3341	249	5	s	s	PROPN
fnp-3341	249	6	,	,	PUNCT
fnp-3341	249	7	katsukura	katsukura	PROPN
fnp-3341	249	8	y	y	PROPN
fnp-3341	249	9	,	,	PUNCT
fnp-3341	249	10	et	et	PROPN
fnp-3341	249	11	al	al	PROPN
fnp-3341	249	12	.	.	PROPN
fnp-3341	249	13	quantitative	quantitative	ADJ
fnp-3341	249	14	targeted	target	VERB
fnp-3341	249	15	absolute	absolute	ADJ
fnp-3341	249	16	proteomics	proteomic	NOUN
fnp-3341	249	17	of	of	ADP
fnp-3341	249	18	human	human	ADJ
fnp-3341	249	19	blood	blood	NOUN
fnp-3341	249	20	-	-	PUNCT
fnp-3341	249	21	brain	brain	NOUN
fnp-3341	249	22	barrier	barrier	NOUN
fnp-3341	249	23	transporters	transporter	NOUN
fnp-3341	249	24	and	and	CCONJ
fnp-3341	249	25	receptors	receptor	NOUN
fnp-3341	249	26	.	.	PUNCT
fnp-3341	250	1	j	j	PROPN
fnp-3341	250	2	neurochem	neurochem	PROPN
fnp-3341	250	3	2011	2011	NUM
fnp-3341	250	4	;	;	PUNCT
fnp-3341	250	5	117(2	117(2	NUM
fnp-3341	250	6	):	):	PUNCT
fnp-3341	250	7	333	333	NUM
fnp-3341	250	8	-	-	SYM
fnp-3341	250	9	45	45	NUM
fnp-3341	250	10	.	.	PUNCT
fnp-3341	250	11	38	38	NUM
fnp-3341	250	12	.	.	PUNCT
fnp-3341	251	1	el	el	PROPN
fnp-3341	251	2	-	-	PUNCT
fnp-3341	251	3	khouly	khouly	PROPN
fnp-3341	251	4	fe	fe	PROPN
fnp-3341	251	5	,	,	PUNCT
fnp-3341	251	6	veldhuijzen	veldhuijzen	NOUN
fnp-3341	251	7	van	van	PROPN
fnp-3341	251	8	zanten	zanten	PROPN
fnp-3341	251	9	sem	sem	PROPN
fnp-3341	251	10	,	,	PUNCT
fnp-3341	251	11	santa	santa	NOUN
fnp-3341	251	12	-	-	PUNCT
fnp-3341	251	13	maria	maria	PROPN
fnp-3341	251	14	lopez	lopez	PROPN
fnp-3341	251	15	v	v	PROPN
fnp-3341	251	16	,	,	PUNCT
fnp-3341	251	17	et	et	PROPN
fnp-3341	251	18	al	al	PROPN
fnp-3341	251	19	.	.	PUNCT
fnp-3341	251	20	diagnostics	diagnostic	NOUN
fnp-3341	251	21	and	and	CCONJ
fnp-3341	251	22	treatment	treatment	NOUN
fnp-3341	251	23	of	of	ADP
fnp-3341	251	24	diffuse	diffuse	NOUN
fnp-3341	251	25	intrinsic	intrinsic	ADJ
fnp-3341	251	26	pontine	pontine	ADJ
fnp-3341	251	27	glioma	glioma	NOUN
fnp-3341	251	28	:	:	PUNCT
fnp-3341	251	29	where	where	SCONJ
fnp-3341	251	30	do	do	AUX
fnp-3341	251	31	we	we	PRON
fnp-3341	251	32	stand	stand	VERB
fnp-3341	251	33	?	?	PUNCT
fnp-3341	252	1	j	j	PROPN
fnp-3341	252	2	neurooncol	neurooncol	ADV
fnp-3341	252	3	2019	2019	NUM
fnp-3341	252	4	;	;	PUNCT
fnp-3341	252	5	145(1	145(1	NUM
fnp-3341	252	6	):	):	PUNCT
fnp-3341	252	7	177	177	NUM
fnp-3341	252	8	-	-	SYM
fnp-3341	252	9	84	84	NUM
fnp-3341	252	10	.	.	PUNCT
fnp-3341	253	1	39	39	NUM
fnp-3341	253	2	.	.	PUNCT
fnp-3341	254	1	veldhuijzen	veldhuijzen	PROPN
fnp-3341	254	2	van	van	PROPN
fnp-3341	254	3	zanten	zanten	PROPN
fnp-3341	254	4	se	se	PROPN
fnp-3341	254	5	,	,	PUNCT
fnp-3341	254	6	jansen	jansen	PROPN
fnp-3341	254	7	mh	mh	PROPN
fnp-3341	254	8	,	,	PUNCT
fnp-3341	254	9	sanchez	sanchez	PROPN
fnp-3341	254	10	aliaga	aliaga	PROPN
fnp-3341	254	11	e	e	PROPN
fnp-3341	254	12	,	,	PUNCT
fnp-3341	254	13	van	van	PROPN
fnp-3341	254	14	vuurden	vuurden	NOUN
fnp-3341	254	15	dg	dg	PROPN
fnp-3341	254	16	,	,	PUNCT
fnp-3341	254	17	vandertop	vandertop	NOUN
fnp-3341	254	18	wp	wp	PROPN
fnp-3341	254	19	,	,	PUNCT
fnp-3341	254	20	kaspers	kaspers	PROPN
fnp-3341	254	21	gj	gj	PROPN
fnp-3341	254	22	.	.	PUNCT
fnp-3341	255	1	a	a	DET
fnp-3341	255	2	twenty	twenty	NUM
fnp-3341	255	3	-	-	PUNCT
fnp-3341	255	4	year	year	NOUN
fnp-3341	255	5	review	review	NOUN
fnp-3341	255	6	of	of	ADP
fnp-3341	255	7	diagnosing	diagnose	VERB
fnp-3341	255	8	and	and	CCONJ
fnp-3341	255	9	treating	treat	VERB
fnp-3341	255	10	children	child	NOUN
fnp-3341	255	11	with	with	ADP
fnp-3341	255	12	diffuse	diffuse	NOUN
fnp-3341	255	13	intrinsic	intrinsic	ADJ
fnp-3341	255	14	pontine	pontine	ADJ
fnp-3341	255	15	glioma	glioma	NOUN
fnp-3341	255	16	in	in	ADP
fnp-3341	255	17	the	the	DET
fnp-3341	255	18	netherlands	netherlands	PROPN
fnp-3341	255	19	.	.	PUNCT
fnp-3341	256	1	expert	expert	NOUN
fnp-3341	256	2	rev	rev	PROPN
fnp-3341	256	3	anticancer	anticancer	NOUN
fnp-3341	256	4	ther	ther	PROPN
fnp-3341	256	5	2015	2015	NUM
fnp-3341	256	6	;	;	PUNCT
fnp-3341	256	7	15(2	15(2	NUM
fnp-3341	256	8	):	):	PUNCT
fnp-3341	256	9	157	157	NUM
fnp-3341	256	10	-	-	SYM
fnp-3341	256	11	64	64	NUM
fnp-3341	256	12	.	.	PUNCT
fnp-3341	256	13	40	40	NUM
fnp-3341	256	14	.	.	PUNCT
fnp-3341	257	1	barua	barua	PROPN
fnp-3341	257	2	nu	nu	PROPN
fnp-3341	257	3	,	,	PUNCT
fnp-3341	257	4	hopkins	hopkins	PROPN
fnp-3341	257	5	k	k	PROPN
fnp-3341	257	6	,	,	PUNCT
fnp-3341	257	7	woolley	woolley	PROPN
fnp-3341	257	8	m	m	PROPN
fnp-3341	257	9	,	,	PUNCT
fnp-3341	257	10	et	et	PROPN
fnp-3341	257	11	al	al	PROPN
fnp-3341	257	12	.	.	PUNCT
fnp-3341	258	1	a	a	DET
fnp-3341	258	2	novel	novel	ADJ
fnp-3341	258	3	implantable	implantable	ADJ
fnp-3341	258	4	catheter	catheter	NOUN
fnp-3341	258	5	system	system	NOUN
fnp-3341	258	6	with	with	ADP
fnp-3341	258	7	transcutaneous	transcutaneous	ADJ
fnp-3341	258	8	port	port	NOUN
fnp-3341	258	9	for	for	ADP
fnp-3341	258	10	intermittent	intermittent	ADJ
fnp-3341	258	11	convection	convection	NOUN
fnp-3341	258	12	-	-	PUNCT
fnp-3341	258	13	enhanced	enhance	VERB
fnp-3341	258	14	delivery	delivery	NOUN
fnp-3341	258	15	of	of	ADP
fnp-3341	258	16	carboplatin	carboplatin	NOUN
fnp-3341	258	17	for	for	ADP
fnp-3341	258	18	recurrent	recurrent	ADJ
fnp-3341	258	19	glioblastoma	glioblastoma	NOUN
fnp-3341	258	20	.	.	PUNCT
fnp-3341	259	1	drug	drug	NOUN
fnp-3341	259	2	deliv	deliv	VERB
fnp-3341	259	3	2016	2016	NUM
fnp-3341	259	4	;	;	PUNCT
fnp-3341	260	1	23(1	23(1	NUM
fnp-3341	260	2	):	):	PUNCT
fnp-3341	260	3	167	167	NUM
fnp-3341	260	4	-	-	SYM
fnp-3341	260	5	73	73	NUM
fnp-3341	260	6	.	.	PUNCT
fnp-3341	261	1	41	41	NUM
fnp-3341	261	2	.	.	PUNCT
fnp-3341	262	1	lewis	lewis	PROPN
fnp-3341	262	2	o	o	PROPN
fnp-3341	262	3	,	,	PUNCT
fnp-3341	262	4	woolley	woolley	PROPN
fnp-3341	262	5	m	m	PROPN
fnp-3341	262	6	,	,	PUNCT
fnp-3341	262	7	johnson	johnson	PROPN
fnp-3341	262	8	d	d	PROPN
fnp-3341	262	9	,	,	PUNCT
fnp-3341	262	10	et	et	PROPN
fnp-3341	262	11	al	al	PROPN
fnp-3341	262	12	.	.	PROPN
fnp-3341	262	13	chronic	chronic	PROPN
fnp-3341	262	14	,	,	PUNCT
fnp-3341	262	15	intermittent	intermittent	ADJ
fnp-3341	262	16	convection	convection	NOUN
fnp-3341	262	17	-	-	PUNCT
fnp-3341	262	18	enhanced	enhance	VERB
fnp-3341	262	19	delivery	delivery	NOUN
fnp-3341	262	20	devices	device	NOUN
fnp-3341	262	21	.	.	PUNCT
fnp-3341	263	1	j	j	PROPN
fnp-3341	263	2	neurosci	neurosci	PROPN
fnp-3341	263	3	methods	method	NOUN
fnp-3341	263	4	2016	2016	NUM
fnp-3341	263	5	;	;	PUNCT
fnp-3341	263	6	259	259	NUM
fnp-3341	263	7	:	:	PUNCT
fnp-3341	263	8	47	47	NUM
fnp-3341	263	9	-	-	SYM
fnp-3341	263	10	56	56	NUM
fnp-3341	263	11	.	.	PUNCT
fnp-3341	264	1	copyright	copyright	NOUN
fnp-3341	264	2	:	:	PUNCT
fnp-3341	264	3	©	©	PROPN
fnp-3341	264	4	2021	2021	NUM
fnp-3341	264	5	the	the	DET
fnp-3341	264	6	author(s	author(s	NOUN
fnp-3341	264	7	)	)	PUNCT
fnp-3341	264	8	.	.	PUNCT
fnp-3341	265	1	this	this	PRON
fnp-3341	265	2	is	be	AUX
fnp-3341	265	3	an	an	DET
fnp-3341	265	4	open	open	ADJ
fnp-3341	265	5	access	access	NOUN
fnp-3341	265	6	article	article	NOUN
fnp-3341	265	7	distributed	distribute	VERB
fnp-3341	265	8	under	under	ADP
fnp-3341	265	9	the	the	DET
fnp-3341	265	10	terms	term	NOUN
fnp-3341	265	11	of	of	ADP
fnp-3341	265	12	the	the	DET
fnp-3341	265	13	creative	creative	ADJ
fnp-3341	265	14	commons	common	NOUN
fnp-3341	265	15	attribution	attribution	NOUN
fnp-3341	265	16	4.0	4.0	NUM
fnp-3341	265	17	international	international	ADJ
fnp-3341	265	18	license	license	NOUN
fnp-3341	265	19	(	(	PUNCT
fnp-3341	265	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-3341	265	21	)	)	PUNCT
fnp-3341	265	22	,	,	PUNCT
fnp-3341	265	23	which	which	PRON
fnp-3341	265	24	permits	permit	VERB
fnp-3341	265	25	unrestricted	unrestricted	ADJ
fnp-3341	265	26	use	use	NOUN
fnp-3341	265	27	,	,	PUNCT
fnp-3341	265	28	distribution	distribution	NOUN
fnp-3341	265	29	,	,	PUNCT
fnp-3341	265	30	and	and	CCONJ
fnp-3341	265	31	reproduction	reproduction	NOUN
fnp-3341	265	32	in	in	ADP
fnp-3341	265	33	any	any	DET
fnp-3341	265	34	medium	medium	NOUN
fnp-3341	265	35	,	,	PUNCT
fnp-3341	265	36	provided	provide	VERB
fnp-3341	265	37	the	the	DET
fnp-3341	265	38	original	original	ADJ
fnp-3341	265	39	author	author	NOUN
fnp-3341	265	40	and	and	CCONJ
fnp-3341	265	41	source	source	NOUN
fnp-3341	265	42	are	be	AUX
fnp-3341	265	43	credited	credit	VERB
fnp-3341	265	44	,	,	PUNCT
fnp-3341	265	45	a	a	DET
fnp-3341	265	46	link	link	NOUN
fnp-3341	265	47	to	to	ADP
fnp-3341	265	48	the	the	DET
fnp-3341	265	49	creative	creative	ADJ
fnp-3341	265	50	commons	common	NOUN
fnp-3341	265	51	license	license	NOUN
fnp-3341	265	52	is	be	AUX
fnp-3341	265	53	provided	provide	VERB
fnp-3341	265	54	,	,	PUNCT
fnp-3341	265	55	and	and	CCONJ
fnp-3341	265	56	any	any	DET
fnp-3341	265	57	changes	change	NOUN
fnp-3341	265	58	are	be	AUX
fnp-3341	265	59	indicated	indicate	VERB
fnp-3341	265	60	.	.	PUNCT
fnp-3341	266	1	the	the	DET
fnp-3341	266	2	creative	creative	ADJ
fnp-3341	266	3	commons	common	NOUN
fnp-3341	266	4	public	public	ADJ
fnp-3341	266	5	domain	domain	NOUN
fnp-3341	266	6	dedication	dedication	NOUN
fnp-3341	266	7	waiver	waiver	NOUN
fnp-3341	266	8	(	(	PUNCT
fnp-3341	266	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-3341	266	10	)	)	PUNCT
fnp-3341	266	11	applies	apply	VERB
fnp-3341	266	12	to	to	ADP
fnp-3341	266	13	the	the	DET
fnp-3341	266	14	data	datum	NOUN
fnp-3341	266	15	made	make	VERB
fnp-3341	266	16	available	available	ADJ
fnp-3341	266	17	in	in	ADP
fnp-3341	266	18	this	this	DET
fnp-3341	266	19	article	article	NOUN
fnp-3341	266	20	,	,	PUNCT
fnp-3341	266	21	unless	unless	SCONJ
fnp-3341	266	22	otherwise	otherwise	ADV
fnp-3341	266	23	stated	state	VERB
fnp-3341	266	24	.	.	PUNCT