id	sid	tid	token	lemma	pos
fnp-3459	1	1	hypothesis	hypothesis	NOUN
fnp-3459	1	2	:	:	PUNCT
fnp-3459	1	3	entrapment	entrapment	NOUN
fnp-3459	1	4	of	of	ADP
fnp-3459	1	5	lipoprotein	lipoprotein	ADJ
fnp-3459	1	6	particles	particle	NOUN
fnp-3459	1	7	in	in	ADP
fnp-3459	1	8	the	the	DET
fnp-3459	1	9	brain	brain	NOUN
fnp-3459	1	10	causes	cause	VERB
fnp-3459	1	11	alzheimer	alzheimer	PROPN
fnp-3459	1	12	’s	’s	PART
fnp-3459	1	13	disease	disease	NOUN
fnp-3459	1	14	feel	feel	VERB
fnp-3459	1	15	free	free	ADJ
fnp-3459	1	16	to	to	PART
fnp-3459	1	17	add	add	VERB
fnp-3459	1	18	comments	comment	NOUN
fnp-3459	1	19	by	by	ADP
fnp-3459	1	20	clicking	click	VERB
fnp-3459	1	21	these	these	DET
fnp-3459	1	22	icons	icon	NOUN
fnp-3459	1	23	on	on	ADP
fnp-3459	1	24	the	the	DET
fnp-3459	1	25	sidebar	sidebar	NOUN
fnp-3459	1	26	free	free	ADJ
fnp-3459	1	27	neuropathology	neuropathology	NOUN
fnp-3459	1	28	2:30	2:30	NUM
fnp-3459	1	29	(	(	PUNCT
fnp-3459	1	30	2021	2021	NUM
fnp-3459	1	31	)	)	PUNCT
fnp-3459	1	32	opinion	opinion	NOUN
fnp-3459	1	33	piece	piece	NOUN
fnp-3459	1	34	hypothesis	hypothesis	NOUN
fnp-3459	1	35	:	:	PUNCT
fnp-3459	1	36	entrapment	entrapment	NOUN
fnp-3459	1	37	of	of	ADP
fnp-3459	1	38	lipoprotein	lipoprotein	ADJ
fnp-3459	1	39	particles	particle	NOUN
fnp-3459	1	40	in	in	ADP
fnp-3459	1	41	the	the	DET
fnp-3459	1	42	brain	brain	NOUN
fnp-3459	1	43	causes	cause	VERB
fnp-3459	1	44	alzheimer	alzheimer	PROPN
fnp-3459	1	45	’s	’s	PART
fnp-3459	1	46	disease	disease	PROPN
fnp-3459	1	47	delphine	delphine	PROPN
fnp-3459	1	48	boche1	boche1	PROPN
fnp-3459	1	49	,	,	PUNCT
fnp-3459	1	50	james	james	PROPN
fnp-3459	1	51	ar	ar	PROPN
fnp-3459	1	52	nicoll1,2	nicoll1,2	PROPN
fnp-3459	1	53	1	1	NUM
fnp-3459	1	54	clinical	clinical	ADJ
fnp-3459	1	55	neurosciences	neuroscience	NOUN
fnp-3459	1	56	,	,	PUNCT
fnp-3459	1	57	clinical	clinical	ADJ
fnp-3459	1	58	and	and	CCONJ
fnp-3459	1	59	experimental	experimental	ADJ
fnp-3459	1	60	science	science	NOUN
fnp-3459	1	61	,	,	PUNCT
fnp-3459	1	62	faculty	faculty	NOUN
fnp-3459	1	63	of	of	ADP
fnp-3459	1	64	medicine	medicine	NOUN
fnp-3459	1	65	,	,	PUNCT
fnp-3459	1	66	university	university	PROPN
fnp-3459	1	67	of	of	ADP
fnp-3459	1	68	southampton	southampton	PROPN
fnp-3459	1	69	,	,	PUNCT
fnp-3459	1	70	southampton	southampton	PROPN
fnp-3459	1	71	,	,	PUNCT
fnp-3459	1	72	united	united	PROPN
fnp-3459	1	73	kingdom	kingdom	PROPN
fnp-3459	1	74	2	2	NUM
fnp-3459	1	75	department	department	NOUN
fnp-3459	1	76	of	of	ADP
fnp-3459	1	77	cellular	cellular	ADJ
fnp-3459	1	78	pathology	pathology	NOUN
fnp-3459	1	79	,	,	PUNCT
fnp-3459	1	80	university	university	NOUN
fnp-3459	1	81	hospital	hospital	PROPN
fnp-3459	1	82	southampton	southampton	PROPN
fnp-3459	1	83	nhs	nhs	PROPN
fnp-3459	1	84	foundation	foundation	PROPN
fnp-3459	1	85	trust	trust	PROPN
fnp-3459	1	86	,	,	PUNCT
fnp-3459	1	87	southampton	southampton	PROPN
fnp-3459	1	88	,	,	PUNCT
fnp-3459	1	89	united	united	PROPN
fnp-3459	1	90	kingdom	kingdom	PROPN
fnp-3459	1	91	corresponding	corresponding	ADJ
fnp-3459	1	92	author	author	NOUN
fnp-3459	1	93	:	:	PUNCT
fnp-3459	1	94	delphine	delphine	PROPN
fnp-3459	1	95	boche	boche	PROPN
fnp-3459	1	96	·	·	PUNCT
fnp-3459	1	97	clinical	clinical	ADJ
fnp-3459	1	98	neurosciences	neuroscience	NOUN
fnp-3459	1	99	,	,	PUNCT
fnp-3459	1	100	clinical	clinical	ADJ
fnp-3459	1	101	and	and	CCONJ
fnp-3459	1	102	experimental	experimental	ADJ
fnp-3459	1	103	sciences	sciences	PROPN
fnp-3459	1	104	academic	academic	ADJ
fnp-3459	1	105	unit	unit	NOUN
fnp-3459	1	106	·	·	PUNCT
fnp-3459	1	107	faculty	faculty	NOUN
fnp-3459	1	108	of	of	ADP
fnp-3459	1	109	medicine	medicine	NOUN
fnp-3459	1	110	·	·	PUNCT
fnp-3459	1	111	university	university	NOUN
fnp-3459	1	112	of	of	ADP
fnp-3459	1	113	southampton	southampton	PROPN
fnp-3459	1	114	·	·	PUNCT
fnp-3459	1	115	southampton	southampton	PROPN
fnp-3459	1	116	general	general	PROPN
fnp-3459	1	117	hospital	hospital	PROPN
fnp-3459	1	118	·	·	PUNCT
fnp-3459	1	119	mailpoint	mailpoint	NOUN
fnp-3459	1	120	806	806	NUM
fnp-3459	1	121	·	·	PUNCT
fnp-3459	1	122	southampton	southampton	PROPN
fnp-3459	1	123	so16	so16	PROPN
fnp-3459	1	124	6	6	NUM
fnp-3459	1	125	yd	yd	NOUN
fnp-3459	1	126	·	·	PUNCT
fnp-3459	1	127	united	united	ADJ
fnp-3459	1	128	kingdom	kingdom	PROPN
fnp-3459	1	129	d.boche@soton.ac.uk	d.boche@soton.ac.uk	PROPN
fnp-3459	1	130	submitted	submit	VERB
fnp-3459	1	131	:	:	PUNCT
fnp-3459	1	132	05	05	NUM
fnp-3459	1	133	august	august	PROPN
fnp-3459	1	134	2021	2021	NUM
fnp-3459	1	135	accepted	accept	VERB
fnp-3459	1	136	:	:	PUNCT
fnp-3459	1	137	21	21	NUM
fnp-3459	1	138	october	october	NOUN
fnp-3459	1	139	2021	2021	NUM
fnp-3459	1	140	copyedited	copyedit	VERB
fnp-3459	1	141	by	by	ADP
fnp-3459	1	142	:	:	PUNCT
fnp-3459	1	143	cinthya	cinthya	NOUN
fnp-3459	1	144	agüero	agüero	NOUN
fnp-3459	1	145	published	publish	VERB
fnp-3459	1	146	:	:	PUNCT
fnp-3459	1	147	02	02	NUM
fnp-3459	1	148	november	november	PROPN
fnp-3459	1	149	2021	2021	NUM
fnp-3459	1	150	https://doi.org/10.17879/freeneuropathology-2021-3459	https://doi.org/10.17879/freeneuropathology-2021-3459	NOUN
fnp-3459	1	151	keywords	keyword	NOUN
fnp-3459	1	152	:	:	PUNCT
fnp-3459	1	153	lipoprotein	lipoprotein	ADJ
fnp-3459	1	154	particles	particle	NOUN
fnp-3459	1	155	,	,	PUNCT
fnp-3459	1	156	extracellular	extracellular	ADJ
fnp-3459	1	157	matrix	matrix	NOUN
fnp-3459	1	158	,	,	PUNCT
fnp-3459	1	159	cholesterol	cholesterol	NOUN
fnp-3459	1	160	transport	transport	NOUN
fnp-3459	1	161	,	,	PUNCT
fnp-3459	1	162	apolipoprotein	apolipoprotein	ADJ
fnp-3459	1	163	e	e	PROPN
fnp-3459	1	164	,	,	PUNCT
fnp-3459	1	165	alzheimer	alzheimer	PROPN
fnp-3459	1	166	’s	’s	PART
fnp-3459	1	167	disease	disease	NOUN
fnp-3459	1	168	abstract	abstract	NOUN
fnp-3459	1	169	we	we	PRON
fnp-3459	1	170	present	present	VERB
fnp-3459	1	171	for	for	ADP
fnp-3459	1	172	consideration	consideration	NOUN
fnp-3459	1	173	a	a	DET
fnp-3459	1	174	hypothesis	hypothesis	NOUN
fnp-3459	1	175	that	that	SCONJ
fnp-3459	1	176	impaired	impaired	ADJ
fnp-3459	1	177	movement	movement	NOUN
fnp-3459	1	178	of	of	ADP
fnp-3459	1	179	lipoprotein	lipoprotein	ADJ
fnp-3459	1	180	particles	particle	NOUN
fnp-3459	1	181	in	in	ADP
fnp-3459	1	182	the	the	DET
fnp-3459	1	183	extracellular	extracellular	ADJ
fnp-3459	1	184	space	space	NOUN
fnp-3459	1	185	in	in	ADP
fnp-3459	1	186	the	the	DET
fnp-3459	1	187	brain	brain	NOUN
fnp-3459	1	188	in	in	ADP
fnp-3459	1	189	ageing	ageing	NOUN
fnp-3459	1	190	is	be	AUX
fnp-3459	1	191	central	central	ADJ
fnp-3459	1	192	to	to	PART
fnp-3459	1	193	and	and	CCONJ
fnp-3459	1	194	causes	cause	VERB
fnp-3459	1	195	all	all	DET
fnp-3459	1	196	the	the	DET
fnp-3459	1	197	key	key	ADJ
fnp-3459	1	198	pathophysiological	pathophysiological	ADJ
fnp-3459	1	199	features	feature	NOUN
fnp-3459	1	200	of	of	ADP
fnp-3459	1	201	alzheimer	alzheimer	PROPN
fnp-3459	1	202	’s	’s	PART
fnp-3459	1	203	disease	disease	NOUN
fnp-3459	1	204	(	(	PUNCT
fnp-3459	1	205	ad	ad	NOUN
fnp-3459	1	206	)	)	PUNCT
fnp-3459	1	207	.	.	PUNCT
fnp-3459	2	1	the	the	DET
fnp-3459	2	2	role	role	NOUN
fnp-3459	2	3	of	of	ADP
fnp-3459	2	4	lipoprotein	lipoprotein	ADJ
fnp-3459	2	5	particles	particle	NOUN
fnp-3459	2	6	is	be	AUX
fnp-3459	2	7	to	to	PART
fnp-3459	2	8	transport	transport	VERB
fnp-3459	2	9	cholesterol	cholesterol	NOUN
fnp-3459	2	10	from	from	ADP
fnp-3459	2	11	glial	glial	ADJ
fnp-3459	2	12	cells	cell	NOUN
fnp-3459	2	13	,	,	PUNCT
fnp-3459	2	14	where	where	SCONJ
fnp-3459	2	15	it	it	PRON
fnp-3459	2	16	is	be	AUX
fnp-3459	2	17	synthesised	synthesise	VERB
fnp-3459	2	18	,	,	PUNCT
fnp-3459	2	19	to	to	ADP
fnp-3459	2	20	neurons	neuron	NOUN
fnp-3459	2	21	,	,	PUNCT
fnp-3459	2	22	which	which	PRON
fnp-3459	2	23	require	require	VERB
fnp-3459	2	24	cholesterol	cholesterol	NOUN
fnp-3459	2	25	for	for	ADP
fnp-3459	2	26	synaptic	synaptic	ADJ
fnp-3459	2	27	plasticity	plasticity	NOUN
fnp-3459	2	28	.	.	PUNCT
fnp-3459	3	1	the	the	DET
fnp-3459	3	2	lipoprotein	lipoprotein	ADJ
fnp-3459	3	3	particles	particle	NOUN
fnp-3459	3	4	have	have	VERB
fnp-3459	3	5	a	a	DET
fnp-3459	3	6	cholesterol	cholesterol	NOUN
fnp-3459	3	7	-	-	PUNCT
fnp-3459	3	8	containing	contain	VERB
fnp-3459	3	9	hydrophobic	hydrophobic	NOUN
fnp-3459	3	10	core	core	NOUN
fnp-3459	3	11	,	,	PUNCT
fnp-3459	3	12	in	in	ADP
fnp-3459	3	13	which	which	PRON
fnp-3459	3	14	amyloid	amyloid	NOUN
fnp-3459	3	15	-	-	PUNCT
fnp-3459	3	16	β	β	X
fnp-3459	3	17	(	(	PUNCT
fnp-3459	3	18	aβ	aβ	NOUN
fnp-3459	3	19	)	)	PUNCT
fnp-3459	3	20	can	can	AUX
fnp-3459	3	21	be	be	AUX
fnp-3459	3	22	solubilised	solubilise	VERB
fnp-3459	3	23	.	.	PUNCT
fnp-3459	4	1	the	the	DET
fnp-3459	4	2	core	core	NOUN
fnp-3459	4	3	is	be	AUX
fnp-3459	4	4	surrounded	surround	VERB
fnp-3459	4	5	by	by	ADP
fnp-3459	4	6	a	a	DET
fnp-3459	4	7	hydrophilic	hydrophilic	ADJ
fnp-3459	4	8	surface	surface	NOUN
fnp-3459	4	9	containing	contain	VERB
fnp-3459	4	10	apolipoprotein	apolipoprotein	ADJ
fnp-3459	4	11	e	e	PROPN
fnp-3459	4	12	(	(	PUNCT
fnp-3459	4	13	apoe	apoe	PROPN
fnp-3459	4	14	)	)	PUNCT
fnp-3459	4	15	which	which	PRON
fnp-3459	4	16	,	,	PUNCT
fnp-3459	4	17	as	as	SCONJ
fnp-3459	4	18	neurons	neuron	NOUN
fnp-3459	4	19	bear	bear	VERB
fnp-3459	4	20	receptors	receptor	NOUN
fnp-3459	4	21	for	for	ADP
fnp-3459	4	22	apoe	apoe	NOUN
fnp-3459	4	23	,	,	PUNCT
fnp-3459	4	24	determines	determine	VERB
fnp-3459	4	25	the	the	DET
fnp-3459	4	26	destination	destination	NOUN
fnp-3459	4	27	of	of	ADP
fnp-3459	4	28	the	the	DET
fnp-3459	4	29	particles	particle	NOUN
fnp-3459	4	30	.	.	PUNCT
fnp-3459	5	1	the	the	DET
fnp-3459	5	2	problem	problem	NOUN
fnp-3459	5	3	arises	arise	VERB
fnp-3459	5	4	because	because	SCONJ
fnp-3459	5	5	the	the	DET
fnp-3459	5	6	extracellular	extracellular	ADJ
fnp-3459	5	7	space	space	NOUN
fnp-3459	5	8	is	be	AUX
fnp-3459	5	9	a	a	DET
fnp-3459	5	10	narrow	narrow	ADJ
fnp-3459	5	11	cleft	cleft	NOUN
fnp-3459	5	12	,	,	PUNCT
fnp-3459	5	13	barely	barely	ADV
fnp-3459	5	14	wider	wide	ADJ
fnp-3459	5	15	than	than	ADP
fnp-3459	5	16	the	the	DET
fnp-3459	5	17	lipoprotein	lipoprotein	ADJ
fnp-3459	5	18	particles	particle	NOUN
fnp-3459	5	19	themselves	themselves	PRON
fnp-3459	5	20	,	,	PUNCT
fnp-3459	5	21	which	which	PRON
fnp-3459	5	22	they	they	PRON
fnp-3459	5	23	have	have	VERB
fnp-3459	5	24	to	to	PART
fnp-3459	5	25	navigate	navigate	VERB
fnp-3459	5	26	in	in	ADP
fnp-3459	5	27	order	order	NOUN
fnp-3459	5	28	to	to	PART
fnp-3459	5	29	perform	perform	VERB
fnp-3459	5	30	their	their	PRON
fnp-3459	5	31	crucial	crucial	ADJ
fnp-3459	5	32	cholesterol	cholesterol	NOUN
fnp-3459	5	33	-	-	PUNCT
fnp-3459	5	34	transporting	transport	VERB
fnp-3459	5	35	function	function	NOUN
fnp-3459	5	36	.	.	PUNCT
fnp-3459	6	1	we	we	PRON
fnp-3459	6	2	explain	explain	VERB
fnp-3459	6	3	how	how	SCONJ
fnp-3459	6	4	lipoprotein	lipoprotein	ADJ
fnp-3459	6	5	particles	particle	NOUN
fnp-3459	6	6	could	could	AUX
fnp-3459	6	7	become	become	VERB
fnp-3459	6	8	trapped	trapped	ADJ
fnp-3459	6	9	in	in	ADP
fnp-3459	6	10	the	the	DET
fnp-3459	6	11	ageing	age	VERB
fnp-3459	6	12	extracellular	extracellular	ADJ
fnp-3459	6	13	matrix	matrix	NOUN
fnp-3459	6	14	and	and	CCONJ
fnp-3459	6	15	that	that	SCONJ
fnp-3459	6	16	this	this	DET
fnp-3459	6	17	primary	primary	ADJ
fnp-3459	6	18	abnormality	abnormality	NOUN
fnp-3459	6	19	results	result	NOUN
fnp-3459	6	20	in	in	ADP
fnp-3459	6	21	reduced	reduced	ADJ
fnp-3459	6	22	delivery	delivery	NOUN
fnp-3459	6	23	of	of	ADP
fnp-3459	6	24	cholesterol	cholesterol	NOUN
fnp-3459	6	25	to	to	ADP
fnp-3459	6	26	neurons	neuron	NOUN
fnp-3459	6	27	leading	lead	VERB
fnp-3459	6	28	to	to	ADP
fnp-3459	6	29	impaired	impaired	ADJ
fnp-3459	6	30	synaptic	synaptic	ADJ
fnp-3459	6	31	plasticity	plasticity	NOUN
fnp-3459	6	32	,	,	PUNCT
fnp-3459	6	33	crucial	crucial	ADJ
fnp-3459	6	34	for	for	ADP
fnp-3459	6	35	learning	learning	NOUN
fnp-3459	6	36	and	and	CCONJ
fnp-3459	6	37	memory	memory	NOUN
fnp-3459	6	38	.	.	PUNCT
fnp-3459	7	1	it	it	PRON
fnp-3459	7	2	can	can	AUX
fnp-3459	7	3	also	also	ADV
fnp-3459	7	4	explain	explain	VERB
fnp-3459	7	5	extracellular	extracellular	ADJ
fnp-3459	7	6	aβ	aβ	NOUN
fnp-3459	7	7	accumulation	accumulation	NOUN
fnp-3459	7	8	,	,	PUNCT
fnp-3459	7	9	to	to	PART
fnp-3459	7	10	which	which	PRON
fnp-3459	7	11	a	a	DET
fnp-3459	7	12	microglial	microglial	ADJ
fnp-3459	7	13	response	response	NOUN
fnp-3459	7	14	generates	generate	VERB
fnp-3459	7	15	a	a	DET
fnp-3459	7	16	neurotoxic	neurotoxic	ADJ
fnp-3459	7	17	reaction	reaction	NOUN
fnp-3459	7	18	,	,	PUNCT
fnp-3459	7	19	and	and	CCONJ
fnp-3459	7	20	intraneuronal	intraneuronal	ADJ
fnp-3459	7	21	tau	tau	PROPN
fnp-3459	7	22	aggregation	aggregation	NOUN
fnp-3459	7	23	,	,	PUNCT
fnp-3459	7	24	each	each	PRON
fnp-3459	7	25	of	of	ADP
fnp-3459	7	26	which	which	PRON
fnp-3459	7	27	exacerbate	exacerbate	VERB
fnp-3459	7	28	the	the	DET
fnp-3459	7	29	problem	problem	NOUN
fnp-3459	7	30	.	.	PUNCT
fnp-3459	8	1	all	all	DET
fnp-3459	8	2	these	these	DET
fnp-3459	8	3	players	player	NOUN
fnp-3459	8	4	have	have	AUX
fnp-3459	8	5	been	be	AUX
fnp-3459	8	6	known	know	VERB
fnp-3459	8	7	for	for	ADP
fnp-3459	8	8	many	many	ADJ
fnp-3459	8	9	years	year	NOUN
fnp-3459	8	10	to	to	PART
fnp-3459	8	11	be	be	AUX
fnp-3459	8	12	important	important	ADJ
fnp-3459	8	13	in	in	ADP
fnp-3459	8	14	alzheimer	alzheimer	PROPN
fnp-3459	8	15	’s	’s	PART
fnp-3459	8	16	pathogenesis	pathogenesis	NOUN
fnp-3459	8	17	but	but	CCONJ
fnp-3459	8	18	a	a	DET
fnp-3459	8	19	single	single	ADJ
fnp-3459	8	20	unifying	unifying	ADJ
fnp-3459	8	21	mechanism	mechanism	NOUN
fnp-3459	8	22	to	to	PART
fnp-3459	8	23	explain	explain	VERB
fnp-3459	8	24	how	how	SCONJ
fnp-3459	8	25	they	they	PRON
fnp-3459	8	26	are	be	AUX
fnp-3459	8	27	linked	link	VERB
fnp-3459	8	28	has	have	AUX
fnp-3459	8	29	been	be	AUX
fnp-3459	8	30	lacking	lack	VERB
fnp-3459	8	31	.	.	PUNCT
fnp-3459	9	1	this	this	DET
fnp-3459	9	2	proposed	propose	VERB
fnp-3459	9	3	mechanism	mechanism	NOUN
fnp-3459	9	4	,	,	PUNCT
fnp-3459	9	5	with	with	ADP
fnp-3459	9	6	entrapment	entrapment	NOUN
fnp-3459	9	7	of	of	ADP
fnp-3459	9	8	lipoproteins	lipoprotein	NOUN
fnp-3459	9	9	particles	particle	NOUN
fnp-3459	9	10	as	as	ADP
fnp-3459	9	11	key	key	ADJ
fnp-3459	9	12	to	to	ADP
fnp-3459	9	13	the	the	DET
fnp-3459	9	14	development	development	NOUN
fnp-3459	9	15	of	of	ADP
fnp-3459	9	16	ad	ad	NOUN
fnp-3459	9	17	,	,	PUNCT
fnp-3459	9	18	can	can	AUX
fnp-3459	9	19	explain	explain	VERB
fnp-3459	9	20	the	the	DET
fnp-3459	9	21	failure	failure	NOUN
fnp-3459	9	22	of	of	ADP
fnp-3459	9	23	so	so	ADV
fnp-3459	9	24	many	many	ADJ
fnp-3459	9	25	clinical	clinical	ADJ
fnp-3459	9	26	trials	trial	NOUN
fnp-3459	9	27	and	and	CCONJ
fnp-3459	9	28	points	point	VERB
fnp-3459	9	29	out	out	ADP
fnp-3459	9	30	new	new	ADJ
fnp-3459	9	31	directions	direction	NOUN
fnp-3459	9	32	to	to	PART
fnp-3459	9	33	be	be	AUX
fnp-3459	9	34	taken	take	VERB
fnp-3459	9	35	.	.	PUNCT
fnp-3459	10	1	genetics	genetic	NOUN
fnp-3459	10	2	shows	show	VERB
fnp-3459	10	3	the	the	DET
fnp-3459	10	4	overriding	override	VERB
fnp-3459	10	5	importance	importance	NOUN
fnp-3459	10	6	of	of	ADP
fnp-3459	10	7	apolipoprotein	apolipoprotein	ADJ
fnp-3459	10	8	e	e	NOUN
fnp-3459	10	9	in	in	ADP
fnp-3459	10	10	a	a	DET
fnp-3459	10	11	complex	complex	ADJ
fnp-3459	10	12	multifaceted	multifaceted	ADJ
fnp-3459	10	13	disease	disease	NOUN
fnp-3459	10	14	process	process	NOUN
fnp-3459	10	15	,	,	PUNCT
fnp-3459	10	16	such	such	ADJ
fnp-3459	10	17	as	as	ADP
fnp-3459	10	18	alzheimer	alzheimer	PROPN
fnp-3459	10	19	’s	’s	PART
fnp-3459	10	20	disease	disease	NOUN
fnp-3459	10	21	(	(	PUNCT
fnp-3459	10	22	ad	ad	NOUN
fnp-3459	10	23	)	)	PUNCT
fnp-3459	10	24	,	,	PUNCT
fnp-3459	10	25	genetic	genetic	ADJ
fnp-3459	10	26	factors	factor	NOUN
fnp-3459	10	27	are	be	AUX
fnp-3459	10	28	important	important	ADJ
fnp-3459	10	29	in	in	ADP
fnp-3459	10	30	highlighting	highlight	VERB
fnp-3459	10	31	key	key	ADJ
fnp-3459	10	32	elements	element	NOUN
fnp-3459	10	33	relevant	relevant	ADJ
fnp-3459	10	34	to	to	ADP
fnp-3459	10	35	the	the	DET
fnp-3459	10	36	onset	onset	NOUN
fnp-3459	10	37	of	of	ADP
fnp-3459	10	38	the	the	DET
fnp-3459	10	39	disease	disease	NOUN
fnp-3459	10	40	.	.	PUNCT
fnp-3459	11	1	by	by	ADP
fnp-3459	11	2	far	far	ADV
fnp-3459	11	3	the	the	DET
fnp-3459	11	4	major	major	ADJ
fnp-3459	11	5	genetic	genetic	ADJ
fnp-3459	11	6	risk	risk	NOUN
fnp-3459	11	7	factor	factor	NOUN
fnp-3459	11	8	for	for	ADP
fnp-3459	11	9	ad	ad	NOUN
fnp-3459	11	10	,	,	PUNCT
fnp-3459	11	11	in	in	ADP
fnp-3459	11	12	terms	term	NOUN
fnp-3459	11	13	of	of	ADP
fnp-3459	11	14	scale	scale	NOUN
fnp-3459	11	15	of	of	ADP
fnp-3459	11	16	effect	effect	NOUN
fnp-3459	11	17	,	,	PUNCT
fnp-3459	11	18	is	be	AUX
fnp-3459	11	19	the	the	DET
fnp-3459	11	20	apolipoprotein	apolipoprotein	ADJ
fnp-3459	11	21	e	e	PROPN
fnp-3459	11	22	genotype	genotype	NOUN
fnp-3459	11	23	(	(	PUNCT
fnp-3459	11	24	gene	gene	NOUN
fnp-3459	11	25	:	:	PUNCT
fnp-3459	11	26	apoe	apoe	ADJ
fnp-3459	11	27	,	,	PUNCT
fnp-3459	11	28	protein	protein	NOUN
fnp-3459	11	29	:	:	PUNCT
fnp-3459	11	30	apoe	apoe	ADJ
fnp-3459	11	31	)	)	PUNCT
fnp-3459	11	32	.	.	PUNCT
fnp-3459	12	1	there	there	PRON
fnp-3459	12	2	are	be	VERB
fnp-3459	12	3	3	3	NUM
fnp-3459	12	4	common	common	ADJ
fnp-3459	12	5	apoe	apoe	ADJ
fnp-3459	12	6	gene	gene	NOUN
fnp-3459	12	7	alleles	allele	NOUN
fnp-3459	12	8	(	(	PUNCT
fnp-3459	12	9	ε2	ε2	ADJ
fnp-3459	12	10	,	,	PUNCT
fnp-3459	12	11	ε3	ε3	PROPN
fnp-3459	12	12	and	and	CCONJ
fnp-3459	12	13	ε4	ε4	PROPN
fnp-3459	12	14	)	)	PUNCT
fnp-3459	12	15	;	;	PUNCT
fnp-3459	12	16	as	as	SCONJ
fnp-3459	12	17	each	each	DET
fnp-3459	12	18	person	person	NOUN
fnp-3459	12	19	inherits	inherit	VERB
fnp-3459	12	20	one	one	NUM
fnp-3459	12	21	allele	allele	NOUN
fnp-3459	12	22	from	from	ADP
fnp-3459	12	23	either	either	DET
fnp-3459	12	24	parent	parent	NOUN
fnp-3459	12	25	there	there	PRON
fnp-3459	12	26	is	be	VERB
fnp-3459	12	27	a	a	DET
fnp-3459	12	28	total	total	NOUN
fnp-3459	12	29	of	of	ADP
fnp-3459	12	30	6	6	NUM
fnp-3459	12	31	apoe	apoe	ADJ
fnp-3459	12	32	genotypes	genotype	NOUN
fnp-3459	12	33	(	(	PUNCT
fnp-3459	12	34	ε2	ε2	NOUN
fnp-3459	12	35	/	/	SYM
fnp-3459	12	36	ε2	ε2	ADJ
fnp-3459	12	37	,	,	PUNCT
fnp-3459	12	38	ε2	ε2	PROPN
fnp-3459	12	39	/	/	SYM
fnp-3459	12	40	ε3	ε3	PROPN
fnp-3459	12	41	,	,	PUNCT
fnp-3459	12	42	ε3	ε3	PROPN
fnp-3459	12	43	/	/	SYM
fnp-3459	12	44	ε3	ε3	PROPN
fnp-3459	12	45	,	,	PUNCT
fnp-3459	12	46	ε3	ε3	PROPN
fnp-3459	12	47	/	/	SYM
fnp-3459	12	48	ε4	ε4	PROPN
fnp-3459	12	49	and	and	CCONJ
fnp-3459	12	50	ε4	ε4	PROPN
fnp-3459	12	51	/	/	SYM
fnp-3459	12	52	ε4	ε4	PROPN
fnp-3459	12	53	)	)	PUNCT
fnp-3459	12	54	.	.	PUNCT
fnp-3459	13	1	the	the	DET
fnp-3459	13	2	apoe	apoe	PROPN
fnp-3459	13	3	ε4	ε4	PROPN
fnp-3459	13	4	allele	allele	NOUN
fnp-3459	13	5	carriage	carriage	NOUN
fnp-3459	13	6	rate	rate	NOUN
fnp-3459	13	7	(	(	PUNCT
fnp-3459	13	8	i.e.	i.e.	X
fnp-3459	13	9	the	the	DET
fnp-3459	13	10	proportion	proportion	NOUN
fnp-3459	13	11	of	of	ADP
fnp-3459	13	12	people	people	NOUN
fnp-3459	13	13	in	in	ADP
fnp-3459	13	14	a	a	DET
fnp-3459	13	15	population	population	NOUN
fnp-3459	13	16	who	who	PRON
fnp-3459	13	17	possess	possess	VERB
fnp-3459	13	18	one	one	NUM
fnp-3459	13	19	or	or	CCONJ
fnp-3459	13	20	two	two	NUM
fnp-3459	13	21	ε4	ε4	NOUN
fnp-3459	13	22	alleles	allele	NOUN
fnp-3459	13	23	)	)	PUNCT
fnp-3459	13	24	is	be	AUX
fnp-3459	13	25	typically	typically	ADV
fnp-3459	13	26	about	about	ADV
fnp-3459	13	27	25	25	NUM
fnp-3459	13	28	%	%	NOUN
fnp-3459	13	29	of	of	ADP
fnp-3459	13	30	people	people	NOUN
fnp-3459	13	31	of	of	ADP
fnp-3459	13	32	european	european	PROPN
fnp-3459	13	33	ancestry	ancestry	PROPN
fnp-3459	14	1	[	[	X
fnp-3459	14	2	1	1	NUM
fnp-3459	14	3	]	]	PUNCT
fnp-3459	14	4	,	,	PUNCT
fnp-3459	14	5	but	but	CCONJ
fnp-3459	14	6	varies	vary	VERB
fnp-3459	14	7	considerably	considerably	ADV
fnp-3459	14	8	around	around	ADP
fnp-3459	14	9	the	the	DET
fnp-3459	14	10	world	world	NOUN
fnp-3459	14	11	among	among	ADP
fnp-3459	14	12	different	different	ADJ
fnp-3459	14	13	populations	population	NOUN
fnp-3459	14	14	[	[	X
fnp-3459	14	15	2	2	NUM
fnp-3459	14	16	]	]	PUNCT
fnp-3459	14	17	.	.	PUNCT
fnp-3459	15	1	a	a	DET
fnp-3459	15	2	single	single	ADJ
fnp-3459	15	3	copy	copy	NOUN
fnp-3459	15	4	of	of	ADP
fnp-3459	15	5	the	the	DET
fnp-3459	15	6	apoe	apoe	PROPN
fnp-3459	15	7	ε4	ε4	NOUN
fnp-3459	15	8	allele	allele	NOUN
fnp-3459	15	9	confers	confer	VERB
fnp-3459	15	10	a	a	DET
fnp-3459	15	11	two	two	NUM
fnp-3459	15	12	to	to	PART
fnp-3459	15	13	fourfold	fourfold	VERB
fnp-3459	15	14	increased	increase	VERB
fnp-3459	15	15	risk	risk	NOUN
fnp-3459	15	16	of	of	ADP
fnp-3459	15	17	developing	develop	VERB
fnp-3459	15	18	ad	ad	NOUN
fnp-3459	15	19	,	,	PUNCT
fnp-3459	15	20	with	with	ADP
fnp-3459	15	21	ε4	ε4	NOUN
fnp-3459	15	22	homozygotes	homozygote	NOUN
fnp-3459	15	23	at	at	ADP
fnp-3459	15	24	fourteen	fourteen	NUM
fnp-3459	15	25	times	time	NOUN
fnp-3459	15	26	increased	increase	VERB
fnp-3459	15	27	risk	risk	NOUN
fnp-3459	15	28	of	of	ADP
fnp-3459	15	29	developing	develop	VERB
fnp-3459	15	30	ad	ad	NOUN
fnp-3459	15	31	,	,	PUNCT
fnp-3459	15	32	whereas	whereas	SCONJ
fnp-3459	15	33	the	the	DET
fnp-3459	15	34	less	less	ADV
fnp-3459	15	35	common	common	ADJ
fnp-3459	15	36	ε2	ε2	ADJ
fnp-3459	15	37	allele	allele	NOUN
fnp-3459	15	38	confers	confer	NOUN
fnp-3459	15	39	relative	relative	ADJ
fnp-3459	15	40	protection	protection	NOUN
fnp-3459	15	41	,	,	PUNCT
fnp-3459	15	42	approximately	approximately	ADV
fnp-3459	15	43	halving	halve	VERB
fnp-3459	15	44	the	the	DET
fnp-3459	15	45	risk	risk	NOUN
fnp-3459	15	46	[	[	X
fnp-3459	15	47	3	3	NUM
fnp-3459	15	48	]	]	PUNCT
fnp-3459	15	49	.	.	PUNCT
fnp-3459	16	1	the	the	DET
fnp-3459	16	2	effect	effect	NOUN
fnp-3459	16	3	is	be	AUX
fnp-3459	16	4	so	so	ADV
fnp-3459	16	5	substantial	substantial	ADJ
fnp-3459	16	6	that	that	SCONJ
fnp-3459	16	7	a	a	DET
fnp-3459	16	8	person	person	NOUN
fnp-3459	16	9	who	who	PRON
fnp-3459	16	10	is	be	AUX
fnp-3459	16	11	ε4	ε4	NOUN
fnp-3459	16	12	homozygous	homozygous	ADJ
fnp-3459	16	13	and	and	CCONJ
fnp-3459	16	14	lives	live	VERB
fnp-3459	16	15	to	to	ADP
fnp-3459	16	16	85	85	NUM
fnp-3459	16	17	years	year	NOUN
fnp-3459	16	18	of	of	ADP
fnp-3459	16	19	age	age	NOUN
fnp-3459	16	20	has	have	VERB
fnp-3459	16	21	a	a	DET
fnp-3459	16	22	lifetime	lifetime	NOUN
fnp-3459	16	23	risk	risk	NOUN
fnp-3459	16	24	of	of	ADP
fnp-3459	16	25	ad	ad	NOUN
fnp-3459	16	26	of	of	ADP
fnp-3459	16	27	more	more	ADJ
fnp-3459	16	28	than	than	ADP
fnp-3459	16	29	50	50	NUM
fnp-3459	16	30	%	%	NOUN
fnp-3459	16	31	,	,	PUNCT
fnp-3459	16	32	comparable	comparable	ADJ
fnp-3459	16	33	to	to	ADP
fnp-3459	16	34	the	the	DET
fnp-3459	16	35	risk	risk	NOUN
fnp-3459	16	36	associated	associate	VERB
fnp-3459	16	37	with	with	ADP
fnp-3459	16	38	brca1	brca1	PROPN
fnp-3459	16	39	mutation	mutation	NOUN
fnp-3459	16	40	in	in	ADP
fnp-3459	16	41	breast	breast	NOUN
fnp-3459	16	42	cancer	cancer	NOUN
fnp-3459	16	43	[	[	X
fnp-3459	16	44	4	4	NUM
fnp-3459	16	45	]	]	PUNCT
fnp-3459	16	46	.	.	PUNCT
fnp-3459	17	1	on	on	ADP
fnp-3459	17	2	the	the	DET
fnp-3459	17	3	other	other	ADJ
fnp-3459	17	4	hand	hand	NOUN
fnp-3459	17	5	,	,	PUNCT
fnp-3459	17	6	the	the	DET
fnp-3459	17	7	protective	protective	ADJ
fnp-3459	17	8	effect	effect	NOUN
fnp-3459	17	9	of	of	ADP
fnp-3459	17	10	apoe	apoe	NOUN
fnp-3459	17	11	ε2	ε2	NOUN
fnp-3459	17	12	is	be	AUX
fnp-3459	17	13	so	so	ADV
fnp-3459	17	14	substantial	substantial	ADJ
fnp-3459	17	15	that	that	SCONJ
fnp-3459	17	16	ε2	ε2	ADJ
fnp-3459	17	17	homozygotes	homozygote	NOUN
fnp-3459	17	18	have	have	VERB
fnp-3459	17	19	a	a	DET
fnp-3459	17	20	very	very	ADV
fnp-3459	17	21	low	low	ADJ
fnp-3459	17	22	likelihood	likelihood	NOUN
fnp-3459	17	23	of	of	ADP
fnp-3459	17	24	developing	develop	VERB
fnp-3459	17	25	ad	ad	NOUN
fnp-3459	17	26	;	;	PUNCT
fnp-3459	17	27	ε2	ε2	ADJ
fnp-3459	17	28	homozygotes	homozygote	NOUN
fnp-3459	17	29	have	have	VERB
fnp-3459	17	30	a	a	DET
fnp-3459	17	31	87	87	NUM
fnp-3459	17	32	%	%	NOUN
fnp-3459	17	33	lower	low	ADJ
fnp-3459	17	34	odds	odd	NOUN
fnp-3459	17	35	ratio	ratio	NOUN
fnp-3459	17	36	than	than	ADP
fnp-3459	17	37	ε3	ε3	ADJ
fnp-3459	17	38	homozygotes	homozygote	NOUN
fnp-3459	17	39	and	and	CCONJ
fnp-3459	17	40	a	a	DET
fnp-3459	17	41	99.6	99.6	NUM
fnp-3459	17	42	%	%	NOUN
fnp-3459	17	43	lower	low	ADJ
fnp-3459	17	44	odds	odd	NOUN
fnp-3459	17	45	ratio	ratio	NOUN
fnp-3459	17	46	than	than	ADP
fnp-3459	17	47	ε4	ε4	NOUN
fnp-3459	17	48	homozygotes	homozygote	NOUN
fnp-3459	17	49	[	[	X
fnp-3459	17	50	5	5	NUM
fnp-3459	17	51	]	]	PUNCT
fnp-3459	17	52	.	.	PUNCT
fnp-3459	18	1	the	the	DET
fnp-3459	18	2	apoe	apoe	ADJ
fnp-3459	18	3	gene	gene	NOUN
fnp-3459	18	4	polymorphism	polymorphism	NOUN
fnp-3459	18	5	is	be	AUX
fnp-3459	18	6	lacking	lack	VERB
fnp-3459	18	7	from	from	ADP
fnp-3459	18	8	non	non	ADJ
fnp-3459	18	9	-	-	ADJ
fnp-3459	18	10	human	human	ADJ
fnp-3459	18	11	primates	primate	NOUN
fnp-3459	18	12	[	[	X
fnp-3459	18	13	6	6	NUM
fnp-3459	18	14	,	,	PUNCT
fnp-3459	18	15	7	7	NUM
fnp-3459	18	16	]	]	PUNCT
fnp-3459	18	17	although	although	SCONJ
fnp-3459	18	18	,	,	PUNCT
fnp-3459	18	19	interestingly	interestingly	ADV
fnp-3459	18	20	,	,	PUNCT
fnp-3459	18	21	rhesus	rhesus	NOUN
fnp-3459	18	22	monkeys	monkey	NOUN
fnp-3459	18	23	which	which	PRON
fnp-3459	18	24	have	have	VERB
fnp-3459	18	25	an	an	DET
fnp-3459	18	26	ε4	ε4	NOUN
fnp-3459	18	27	-	-	PUNCT
fnp-3459	18	28	like	like	ADJ
fnp-3459	18	29	apoe	apoe	NOUN
fnp-3459	18	30	sequence	sequence	NOUN
fnp-3459	18	31	develop	develop	VERB
fnp-3459	18	32	aβ	aβ	ADP
fnp-3459	18	33	plaques	plaque	NOUN
fnp-3459	18	34	as	as	SCONJ
fnp-3459	18	35	they	they	PRON
fnp-3459	18	36	age	age	VERB
fnp-3459	19	1	[	[	X
fnp-3459	19	2	8	8	NUM
fnp-3459	19	3	]	]	PUNCT
fnp-3459	19	4	.	.	PUNCT
fnp-3459	20	1	the	the	DET
fnp-3459	20	2	fact	fact	NOUN
fnp-3459	20	3	that	that	SCONJ
fnp-3459	20	4	there	there	PRON
fnp-3459	20	5	are	be	VERB
fnp-3459	20	6	more	more	ADJ
fnp-3459	20	7	than	than	ADP
fnp-3459	20	8	200	200	NUM
fnp-3459	20	9	animal	animal	NOUN
fnp-3459	20	10	models	model	NOUN
fnp-3459	20	11	of	of	ADP
fnp-3459	20	12	ad	ad	NOUN
fnp-3459	20	13	highlights	highlight	NOUN
fnp-3459	20	14	the	the	DET
fnp-3459	20	15	difficulty	difficulty	NOUN
fnp-3459	20	16	in	in	ADP
fnp-3459	20	17	mimicking	mimic	VERB
fnp-3459	20	18	the	the	DET
fnp-3459	20	19	complexity	complexity	NOUN
fnp-3459	20	20	of	of	ADP
fnp-3459	20	21	the	the	DET
fnp-3459	20	22	human	human	ADJ
fnp-3459	20	23	disease	disease	NOUN
fnp-3459	20	24	in	in	ADP
fnp-3459	20	25	experimental	experimental	ADJ
fnp-3459	20	26	animals	animal	NOUN
fnp-3459	20	27	.	.	PUNCT
fnp-3459	21	1	a	a	DET
fnp-3459	21	2	complete	complete	ADJ
fnp-3459	21	3	understanding	understanding	NOUN
fnp-3459	21	4	of	of	ADP
fnp-3459	21	5	the	the	DET
fnp-3459	21	6	pathophysiology	pathophysiology	NOUN
fnp-3459	21	7	of	of	ADP
fnp-3459	21	8	ad	ad	NOUN
fnp-3459	21	9	ideally	ideally	ADV
fnp-3459	21	10	would	would	AUX
fnp-3459	21	11	explain	explain	VERB
fnp-3459	21	12	all	all	DET
fnp-3459	21	13	aspects	aspect	NOUN
fnp-3459	21	14	of	of	ADP
fnp-3459	21	15	the	the	DET
fnp-3459	21	16	human	human	ADJ
fnp-3459	21	17	disease	disease	NOUN
fnp-3459	21	18	,	,	PUNCT
fnp-3459	21	19	and	and	CCONJ
fnp-3459	21	20	in	in	ADP
fnp-3459	21	21	particular	particular	ADJ
fnp-3459	21	22	incorporate	incorporate	VERB
fnp-3459	21	23	the	the	DET
fnp-3459	21	24	role	role	NOUN
fnp-3459	21	25	of	of	ADP
fnp-3459	21	26	the	the	DET
fnp-3459	21	27	apoe	apoe	ADJ
fnp-3459	21	28	protein	protein	NOUN
fnp-3459	21	29	;	;	PUNCT
fnp-3459	21	30	how	how	SCONJ
fnp-3459	21	31	it	it	PRON
fnp-3459	21	32	causes	cause	VERB
fnp-3459	21	33	and	and	CCONJ
fnp-3459	21	34	interacts	interact	VERB
fnp-3459	21	35	with	with	ADP
fnp-3459	21	36	the	the	DET
fnp-3459	21	37	accumulation	accumulation	NOUN
fnp-3459	21	38	of	of	ADP
fnp-3459	21	39	amyloid	amyloid	NOUN
fnp-3459	21	40	-	-	PUNCT
fnp-3459	21	41	β	β	X
fnp-3459	21	42	(	(	PUNCT
fnp-3459	21	43	aβ	aβ	NOUN
fnp-3459	21	44	)	)	PUNCT
fnp-3459	21	45	and	and	CCONJ
fnp-3459	21	46	tau	tau	PROPN
fnp-3459	21	47	proteins	protein	NOUN
fnp-3459	21	48	,	,	PUNCT
fnp-3459	21	49	the	the	DET
fnp-3459	21	50	glial	glial	ADJ
fnp-3459	21	51	cell	cell	NOUN
fnp-3459	21	52	activity	activity	NOUN
fnp-3459	21	53	and	and	CCONJ
fnp-3459	21	54	most	most	ADV
fnp-3459	21	55	importantly	importantly	ADV
fnp-3459	21	56	,	,	PUNCT
fnp-3459	21	57	the	the	DET
fnp-3459	21	58	neuronal	neuronal	ADJ
fnp-3459	21	59	and	and	CCONJ
fnp-3459	21	60	synaptic	synaptic	ADJ
fnp-3459	21	61	dysfunction	dysfunction	NOUN
fnp-3459	21	62	and	and	CCONJ
fnp-3459	21	63	loss	loss	NOUN
fnp-3459	21	64	.	.	PUNCT
fnp-3459	22	1	the	the	DET
fnp-3459	22	2	function	function	NOUN
fnp-3459	22	3	of	of	ADP
fnp-3459	22	4	apoe	apoe	NOUN
fnp-3459	22	5	is	be	AUX
fnp-3459	22	6	to	to	PART
fnp-3459	22	7	deliver	deliver	VERB
fnp-3459	22	8	cholesterol	cholesterol	NOUN
fnp-3459	22	9	,	,	PUNCT
fnp-3459	22	10	packaged	package	VERB
fnp-3459	22	11	in	in	ADP
fnp-3459	22	12	lipoprotein	lipoprotein	ADJ
fnp-3459	22	13	particles	particle	NOUN
fnp-3459	22	14	,	,	PUNCT
fnp-3459	22	15	to	to	ADP
fnp-3459	22	16	neurons	neuron	NOUN
fnp-3459	22	17	apoe	apoe	NOUN
fnp-3459	22	18	is	be	AUX
fnp-3459	22	19	the	the	DET
fnp-3459	22	20	principal	principal	ADJ
fnp-3459	22	21	cholesterol	cholesterol	NOUN
fnp-3459	22	22	carrier	carrier	NOUN
fnp-3459	22	23	in	in	ADP
fnp-3459	22	24	the	the	DET
fnp-3459	22	25	brain	brain	NOUN
fnp-3459	22	26	,	,	PUNCT
fnp-3459	22	27	acting	act	VERB
fnp-3459	22	28	as	as	ADP
fnp-3459	22	29	a	a	DET
fnp-3459	22	30	detergent	detergent	NOUN
fnp-3459	22	31	with	with	ADP
fnp-3459	22	32	hydrophobic	hydrophobic	NOUN
fnp-3459	22	33	and	and	CCONJ
fnp-3459	22	34	hydrophilic	hydrophilic	ADJ
fnp-3459	22	35	moieties	moiety	NOUN
fnp-3459	22	36	.	.	PUNCT
fnp-3459	23	1	its	its	PRON
fnp-3459	23	2	main	main	ADJ
fnp-3459	23	3	role	role	NOUN
fnp-3459	23	4	is	be	AUX
fnp-3459	23	5	to	to	PART
fnp-3459	23	6	solubilise	solubilise	VERB
fnp-3459	23	7	cholesterol	cholesterol	NOUN
fnp-3459	23	8	and	and	CCONJ
fnp-3459	23	9	other	other	ADJ
fnp-3459	23	10	lipids	lipid	NOUN
fnp-3459	23	11	and	and	CCONJ
fnp-3459	23	12	lipid	lipid	NOUN
fnp-3459	23	13	-	-	PUNCT
fnp-3459	23	14	soluble	soluble	ADJ
fnp-3459	23	15	substances	substance	NOUN
fnp-3459	23	16	to	to	PART
fnp-3459	23	17	enable	enable	VERB
fnp-3459	23	18	them	they	PRON
fnp-3459	23	19	to	to	PART
fnp-3459	23	20	be	be	AUX
fnp-3459	23	21	transported	transport	VERB
fnp-3459	23	22	in	in	ADP
fnp-3459	23	23	the	the	DET
fnp-3459	23	24	aqueous	aqueous	ADJ
fnp-3459	23	25	extracellular	extracellular	ADJ
fnp-3459	23	26	environment	environment	NOUN
fnp-3459	23	27	of	of	ADP
fnp-3459	23	28	the	the	DET
fnp-3459	23	29	brain	brain	NOUN
fnp-3459	23	30	.	.	PUNCT
fnp-3459	24	1	the	the	DET
fnp-3459	24	2	importance	importance	NOUN
fnp-3459	24	3	of	of	ADP
fnp-3459	24	4	cholesterol	cholesterol	NOUN
fnp-3459	24	5	to	to	ADP
fnp-3459	24	6	the	the	DET
fnp-3459	24	7	brain	brain	NOUN
fnp-3459	24	8	is	be	AUX
fnp-3459	24	9	highlighted	highlight	VERB
fnp-3459	24	10	by	by	ADP
fnp-3459	24	11	the	the	DET
fnp-3459	24	12	fact	fact	NOUN
fnp-3459	24	13	that	that	SCONJ
fnp-3459	24	14	25	25	NUM
fnp-3459	24	15	%	%	NOUN
fnp-3459	24	16	of	of	ADP
fnp-3459	24	17	the	the	DET
fnp-3459	24	18	body	body	NOUN
fnp-3459	24	19	’s	’s	PART
fnp-3459	24	20	cholesterol	cholesterol	NOUN
fnp-3459	24	21	is	be	AUX
fnp-3459	24	22	contained	contain	VERB
fnp-3459	24	23	within	within	ADP
fnp-3459	24	24	the	the	DET
fnp-3459	24	25	brain	brain	NOUN
fnp-3459	24	26	,	,	PUNCT
fnp-3459	24	27	despite	despite	SCONJ
fnp-3459	24	28	the	the	DET
fnp-3459	24	29	brain	brain	NOUN
fnp-3459	24	30	representing	represent	VERB
fnp-3459	24	31	only	only	ADV
fnp-3459	24	32	2	2	NUM
fnp-3459	24	33	%	%	NOUN
fnp-3459	24	34	of	of	ADP
fnp-3459	24	35	the	the	DET
fnp-3459	24	36	body	body	NOUN
fnp-3459	24	37	weight	weight	NOUN
fnp-3459	25	1	[	[	X
fnp-3459	25	2	9	9	NUM
fnp-3459	25	3	]	]	PUNCT
fnp-3459	25	4	.	.	PUNCT
fnp-3459	26	1	cholesterol	cholesterol	NOUN
fnp-3459	26	2	forms	form	NOUN
fnp-3459	26	3	about	about	ADV
fnp-3459	26	4	30	30	NUM
fnp-3459	26	5	%	%	NOUN
fnp-3459	26	6	of	of	ADP
fnp-3459	26	7	the	the	DET
fnp-3459	26	8	lipid	lipid	ADJ
fnp-3459	26	9	bilayer	bilayer	NOUN
fnp-3459	26	10	of	of	ADP
fnp-3459	26	11	the	the	DET
fnp-3459	26	12	membrane	membrane	NOUN
fnp-3459	26	13	of	of	ADP
fnp-3459	26	14	all	all	DET
fnp-3459	26	15	cells	cell	NOUN
fnp-3459	26	16	and	and	CCONJ
fnp-3459	26	17	is	be	AUX
fnp-3459	26	18	important	important	ADJ
fnp-3459	26	19	in	in	ADP
fnp-3459	26	20	maintaining	maintain	VERB
fnp-3459	26	21	membrane	membrane	NOUN
fnp-3459	26	22	fluidity	fluidity	NOUN
fnp-3459	26	23	.	.	PUNCT
fnp-3459	27	1	in	in	ADP
fnp-3459	27	2	the	the	DET
fnp-3459	27	3	brain	brain	NOUN
fnp-3459	27	4	,	,	PUNCT
fnp-3459	27	5	the	the	DET
fnp-3459	27	6	cell	cell	NOUN
fnp-3459	27	7	membrane	membrane	NOUN
fnp-3459	27	8	is	be	AUX
fnp-3459	27	9	essential	essential	ADJ
fnp-3459	27	10	for	for	ADP
fnp-3459	27	11	conducting	conduct	VERB
fnp-3459	27	12	the	the	DET
fnp-3459	27	13	action	action	NOUN
fnp-3459	27	14	potential	potential	NOUN
fnp-3459	27	15	and	and	CCONJ
fnp-3459	27	16	for	for	ADP
fnp-3459	27	17	communication	communication	NOUN
fnp-3459	27	18	between	between	ADP
fnp-3459	27	19	neurons	neuron	NOUN
fnp-3459	27	20	at	at	ADP
fnp-3459	27	21	synapses	synapsis	NOUN
fnp-3459	27	22	.	.	PUNCT
fnp-3459	28	1	however	however	ADV
fnp-3459	28	2	,	,	PUNCT
fnp-3459	28	3	despite	despite	SCONJ
fnp-3459	28	4	its	its	PRON
fnp-3459	28	5	importance	importance	NOUN
fnp-3459	28	6	to	to	ADP
fnp-3459	28	7	neuronal	neuronal	ADJ
fnp-3459	28	8	function	function	NOUN
fnp-3459	28	9	,	,	PUNCT
fnp-3459	28	10	neurons	neuron	NOUN
fnp-3459	28	11	do	do	AUX
fnp-3459	28	12	not	not	PART
fnp-3459	28	13	synthesise	synthesise	VERB
fnp-3459	28	14	their	their	PRON
fnp-3459	28	15	own	own	ADJ
fnp-3459	28	16	cholesterol	cholesterol	NOUN
fnp-3459	28	17	,	,	PUNCT
fnp-3459	28	18	but	but	CCONJ
fnp-3459	28	19	rely	rely	VERB
fnp-3459	28	20	on	on	ADP
fnp-3459	28	21	cholesterol	cholesterol	NOUN
fnp-3459	28	22	which	which	PRON
fnp-3459	28	23	is	be	AUX
fnp-3459	28	24	synthesised	synthesise	VERB
fnp-3459	28	25	by	by	ADP
fnp-3459	28	26	glial	glial	ADJ
fnp-3459	28	27	cells	cell	NOUN
fnp-3459	28	28	and	and	CCONJ
fnp-3459	28	29	then	then	ADV
fnp-3459	28	30	transported	transport	VERB
fnp-3459	28	31	to	to	ADP
fnp-3459	28	32	neurons	neuron	NOUN
fnp-3459	28	33	[	[	X
fnp-3459	28	34	10	10	NUM
fnp-3459	28	35	]	]	PUNCT
fnp-3459	28	36	.	.	PUNCT
fnp-3459	29	1	delivery	delivery	NOUN
fnp-3459	29	2	of	of	ADP
fnp-3459	29	3	cholesterol	cholesterol	NOUN
fnp-3459	29	4	to	to	ADP
fnp-3459	29	5	neurons	neuron	NOUN
fnp-3459	29	6	is	be	AUX
fnp-3459	29	7	in	in	ADP
fnp-3459	29	8	particular	particular	ADJ
fnp-3459	29	9	demand	demand	NOUN
fnp-3459	29	10	when	when	SCONJ
fnp-3459	29	11	the	the	DET
fnp-3459	29	12	neuron	neuron	NOUN
fnp-3459	29	13	changes	change	VERB
fnp-3459	29	14	,	,	PUNCT
fnp-3459	29	15	as	as	ADP
fnp-3459	29	16	in	in	ADP
fnp-3459	29	17	synaptic	synaptic	ADJ
fnp-3459	29	18	plasticity	plasticity	NOUN
fnp-3459	29	19	which	which	PRON
fnp-3459	29	20	underpins	underpin	VERB
fnp-3459	29	21	learning	learning	NOUN
fnp-3459	29	22	and	and	CCONJ
fnp-3459	29	23	memory	memory	NOUN
fnp-3459	29	24	which	which	PRON
fnp-3459	29	25	are	be	AUX
fnp-3459	29	26	particularly	particularly	ADV
fnp-3459	29	27	affected	affect	VERB
fnp-3459	29	28	in	in	ADP
fnp-3459	29	29	ad	ad	NOUN
fnp-3459	29	30	[	[	X
fnp-3459	29	31	11	11	NUM
fnp-3459	29	32	]	]	PUNCT
fnp-3459	29	33	.	.	PUNCT
fnp-3459	30	1	of	of	ADP
fnp-3459	30	2	note	note	NOUN
fnp-3459	30	3	,	,	PUNCT
fnp-3459	30	4	genome	genome	NOUN
fnp-3459	30	5	-	-	PUNCT
fnp-3459	30	6	wide	wide	ADJ
fnp-3459	30	7	association	association	NOUN
fnp-3459	30	8	studies	study	NOUN
fnp-3459	30	9	have	have	AUX
fnp-3459	30	10	highlighted	highlight	VERB
fnp-3459	30	11	polymorphisms	polymorphism	NOUN
fnp-3459	30	12	in	in	ADP
fnp-3459	30	13	genes	gene	NOUN
fnp-3459	30	14	in	in	ADP
fnp-3459	30	15	addition	addition	NOUN
fnp-3459	30	16	to	to	ADP
fnp-3459	30	17	apoe	apoe	NOUN
fnp-3459	30	18	that	that	PRON
fnp-3459	30	19	are	be	AUX
fnp-3459	30	20	involved	involve	VERB
fnp-3459	30	21	in	in	ADP
fnp-3459	30	22	cholesterol	cholesterol	NOUN
fnp-3459	30	23	handling	handling	NOUN
fnp-3459	30	24	(	(	PUNCT
fnp-3459	30	25	clu	clu	PROPN
fnp-3459	30	26	,	,	PUNCT
fnp-3459	30	27	picalm	picalm	ADJ
fnp-3459	30	28	,	,	PUNCT
fnp-3459	30	29	bin1	bin1	NOUN
fnp-3459	30	30	and	and	CCONJ
fnp-3459	30	31	abca7	abca7	PROPN
fnp-3459	30	32	)	)	PUNCT
fnp-3459	30	33	as	as	ADP
fnp-3459	30	34	risk	risk	NOUN
fnp-3459	30	35	factors	factor	NOUN
fnp-3459	30	36	for	for	ADP
fnp-3459	30	37	ad	ad	NOUN
fnp-3459	30	38	[	[	X
fnp-3459	30	39	12	12	NUM
fnp-3459	30	40	,	,	PUNCT
fnp-3459	30	41	13	13	NUM
fnp-3459	30	42	]	]	PUNCT
fnp-3459	30	43	,	,	PUNCT
fnp-3459	30	44	supporting	support	VERB
fnp-3459	30	45	an	an	DET
fnp-3459	30	46	important	important	ADJ
fnp-3459	30	47	role	role	NOUN
fnp-3459	30	48	for	for	ADP
fnp-3459	30	49	cholesterol	cholesterol	NOUN
fnp-3459	30	50	handling	handling	NOUN
fnp-3459	30	51	in	in	ADP
fnp-3459	30	52	the	the	DET
fnp-3459	30	53	disease	disease	NOUN
fnp-3459	30	54	mechanism	mechanism	NOUN
fnp-3459	30	55	[	[	X
fnp-3459	30	56	14	14	NUM
fnp-3459	30	57	,	,	PUNCT
fnp-3459	30	58	15	15	NUM
fnp-3459	30	59	]	]	PUNCT
fnp-3459	30	60	.	.	PUNCT
fnp-3459	31	1	apoe	apoe	PROPN
fnp-3459	31	2	is	be	AUX
fnp-3459	31	3	located	locate	VERB
fnp-3459	31	4	in	in	ADP
fnp-3459	31	5	the	the	DET
fnp-3459	31	6	shell	shell	NOUN
fnp-3459	31	7	of	of	ADP
fnp-3459	31	8	lipoprotein	lipoprotein	ADJ
fnp-3459	31	9	particles	particle	NOUN
fnp-3459	31	10	,	,	PUNCT
fnp-3459	31	11	with	with	ADP
fnp-3459	31	12	hydrophobic	hydrophobic	NOUN
fnp-3459	31	13	substances	substance	NOUN
fnp-3459	31	14	including	include	VERB
fnp-3459	31	15	cholesterol	cholesterol	NOUN
fnp-3459	31	16	,	,	PUNCT
fnp-3459	31	17	which	which	PRON
fnp-3459	31	18	is	be	AUX
fnp-3459	31	19	loaded	load	VERB
fnp-3459	31	20	onto	onto	ADP
fnp-3459	31	21	the	the	DET
fnp-3459	31	22	lipoprotein	lipoprotein	ADJ
fnp-3459	31	23	particle	particle	NOUN
fnp-3459	31	24	by	by	ADP
fnp-3459	31	25	the	the	DET
fnp-3459	31	26	enzyme	enzyme	NOUN
fnp-3459	31	27	abca1	abca1	NOUN
fnp-3459	31	28	,	,	PUNCT
fnp-3459	31	29	being	be	AUX
fnp-3459	31	30	transported	transport	VERB
fnp-3459	31	31	in	in	ADP
fnp-3459	31	32	the	the	DET
fnp-3459	31	33	core	core	NOUN
fnp-3459	31	34	[	[	X
fnp-3459	31	35	16	16	NUM
fnp-3459	31	36	]	]	PUNCT
fnp-3459	31	37	.	.	PUNCT
fnp-3459	32	1	the	the	DET
fnp-3459	32	2	destination	destination	NOUN
fnp-3459	32	3	of	of	ADP
fnp-3459	32	4	the	the	DET
fnp-3459	32	5	lipoprotein	lipoprotein	ADJ
fnp-3459	32	6	particles	particle	NOUN
fnp-3459	32	7	is	be	AUX
fnp-3459	32	8	determined	determine	VERB
fnp-3459	32	9	by	by	ADP
fnp-3459	32	10	the	the	DET
fnp-3459	32	11	receptors	receptor	NOUN
fnp-3459	32	12	for	for	ADP
fnp-3459	32	13	the	the	DET
fnp-3459	32	14	proteins	protein	NOUN
fnp-3459	32	15	on	on	ADP
fnp-3459	32	16	the	the	DET
fnp-3459	32	17	surface	surface	NOUN
fnp-3459	32	18	of	of	ADP
fnp-3459	32	19	the	the	DET
fnp-3459	32	20	lipoprotein	lipoprotein	ADJ
fnp-3459	32	21	shell	shell	NOUN
fnp-3459	32	22	.	.	PUNCT
fnp-3459	33	1	apoe	apoe	PROPN
fnp-3459	33	2	,	,	PUNCT
fnp-3459	33	3	on	on	ADP
fnp-3459	33	4	the	the	DET
fnp-3459	33	5	outer	outer	ADJ
fnp-3459	33	6	surface	surface	NOUN
fnp-3459	33	7	of	of	ADP
fnp-3459	33	8	the	the	DET
fnp-3459	33	9	lipoprotein	lipoprotein	ADJ
fnp-3459	33	10	particles	particle	NOUN
fnp-3459	33	11	,	,	PUNCT
fnp-3459	33	12	binds	bind	VERB
fnp-3459	33	13	to	to	ADP
fnp-3459	33	14	receptors	receptor	NOUN
fnp-3459	33	15	of	of	ADP
fnp-3459	33	16	the	the	DET
fnp-3459	33	17	low	low	ADJ
fnp-3459	33	18	-	-	PUNCT
fnp-3459	33	19	density	density	NOUN
fnp-3459	33	20	lipoprotein	lipoprotein	ADJ
fnp-3459	33	21	(	(	PUNCT
fnp-3459	33	22	ldl	ldl	NOUN
fnp-3459	33	23	)	)	PUNCT
fnp-3459	33	24	receptor	receptor	NOUN
fnp-3459	33	25	family	family	NOUN
fnp-3459	33	26	(	(	PUNCT
fnp-3459	33	27	principally	principally	ADV
fnp-3459	33	28	lrp1	lrp1	NOUN
fnp-3459	33	29	/	/	SYM
fnp-3459	33	30	apoe	apoe	ADJ
fnp-3459	33	31	receptor	receptor	NOUN
fnp-3459	33	32	)	)	PUNCT
fnp-3459	33	33	present	present	ADJ
fnp-3459	33	34	on	on	ADP
fnp-3459	33	35	neuronal	neuronal	ADJ
fnp-3459	33	36	cell	cell	NOUN
fnp-3459	33	37	membranes	membrane	NOUN
fnp-3459	33	38	and	and	CCONJ
fnp-3459	33	39	,	,	PUNCT
fnp-3459	33	40	by	by	ADP
fnp-3459	33	41	this	this	DET
fnp-3459	33	42	mechanism	mechanism	NOUN
fnp-3459	33	43	,	,	PUNCT
fnp-3459	33	44	the	the	DET
fnp-3459	33	45	cholesterol	cholesterol	NOUN
fnp-3459	33	46	is	be	AUX
fnp-3459	33	47	internalised	internalise	VERB
fnp-3459	33	48	within	within	ADP
fnp-3459	33	49	the	the	DET
fnp-3459	33	50	neurons	neuron	NOUN
fnp-3459	33	51	.	.	PUNCT
fnp-3459	34	1	some	some	DET
fnp-3459	34	2	cns	cns	NOUN
fnp-3459	34	3	lipoprotein	lipoprotein	ADJ
fnp-3459	34	4	particles	particle	NOUN
fnp-3459	34	5	also	also	ADV
fnp-3459	34	6	bear	bear	VERB
fnp-3459	34	7	apoj	apoj	PROPN
fnp-3459	34	8	(	(	PUNCT
fnp-3459	34	9	clusterin	clusterin	NOUN
fnp-3459	34	10	)	)	PUNCT
fnp-3459	34	11	on	on	ADP
fnp-3459	34	12	their	their	PRON
fnp-3459	34	13	surface	surface	NOUN
fnp-3459	34	14	;	;	PUNCT
fnp-3459	34	15	ependymal	ependymal	ADJ
fnp-3459	34	16	cells	cell	NOUN
fnp-3459	34	17	,	,	PUNCT
fnp-3459	34	18	but	but	CCONJ
fnp-3459	34	19	not	not	PART
fnp-3459	34	20	neurons	neuron	NOUN
fnp-3459	34	21	or	or	CCONJ
fnp-3459	34	22	other	other	ADJ
fnp-3459	34	23	glia	glia	NOUN
fnp-3459	34	24	,	,	PUNCT
fnp-3459	34	25	bear	bear	VERB
fnp-3459	34	26	apoj	apoj	NOUN
fnp-3459	34	27	receptors	receptor	NOUN
fnp-3459	34	28	so	so	SCONJ
fnp-3459	34	29	it	it	PRON
fnp-3459	34	30	is	be	AUX
fnp-3459	34	31	unlikely	unlikely	ADJ
fnp-3459	34	32	to	to	PART
fnp-3459	34	33	be	be	AUX
fnp-3459	34	34	relevant	relevant	ADJ
fnp-3459	34	35	for	for	ADP
fnp-3459	34	36	cholesterol	cholesterol	NOUN
fnp-3459	34	37	delivery	delivery	NOUN
fnp-3459	34	38	to	to	ADP
fnp-3459	34	39	neurons	neuron	NOUN
fnp-3459	34	40	[	[	X
fnp-3459	34	41	17	17	NUM
fnp-3459	34	42	]	]	PUNCT
fnp-3459	34	43	.	.	PUNCT
fnp-3459	35	1	however	however	ADV
fnp-3459	35	2	,	,	PUNCT
fnp-3459	35	3	it	it	PRON
fnp-3459	35	4	is	be	AUX
fnp-3459	35	5	notable	notable	ADJ
fnp-3459	35	6	that	that	SCONJ
fnp-3459	35	7	in	in	ADP
fnp-3459	35	8	genome	genome	NOUN
fnp-3459	35	9	-	-	PUNCT
fnp-3459	35	10	wide	wide	ADJ
fnp-3459	35	11	association	association	NOUN
fnp-3459	35	12	studies	study	NOUN
fnp-3459	35	13	,	,	PUNCT
fnp-3459	35	14	polymorphism	polymorphism	NOUN
fnp-3459	35	15	of	of	ADP
fnp-3459	35	16	apoj	apoj	PROPN
fnp-3459	35	17	/	/	SYM
fnp-3459	35	18	clusterin	clusterin	NOUN
fnp-3459	35	19	gene	gene	NOUN
fnp-3459	35	20	has	have	AUX
fnp-3459	35	21	also	also	ADV
fnp-3459	35	22	been	be	AUX
fnp-3459	35	23	shown	show	VERB
fnp-3459	35	24	to	to	PART
fnp-3459	35	25	influence	influence	VERB
fnp-3459	35	26	risk	risk	NOUN
fnp-3459	35	27	for	for	ADP
fnp-3459	35	28	ad	ad	NOUN
fnp-3459	35	29	[	[	X
fnp-3459	35	30	18	18	NUM
fnp-3459	35	31	]	]	PUNCT
fnp-3459	35	32	,	,	PUNCT
fnp-3459	35	33	raising	raise	VERB
fnp-3459	35	34	the	the	DET
fnp-3459	35	35	possible	possible	ADJ
fnp-3459	35	36	importance	importance	NOUN
fnp-3459	35	37	of	of	ADP
fnp-3459	35	38	clearance	clearance	NOUN
fnp-3459	35	39	of	of	ADP
fnp-3459	35	40	lipoprotein	lipoprotein	ADJ
fnp-3459	35	41	particles	particle	NOUN
fnp-3459	35	42	and	and	CCONJ
fnp-3459	35	43	cholesterol	cholesterol	NOUN
fnp-3459	35	44	to	to	ADP
fnp-3459	35	45	the	the	DET
fnp-3459	35	46	csf	csf	PROPN
fnp-3459	35	47	.	.	PROPN
fnp-3459	35	48	outside	outside	ADP
fnp-3459	35	49	the	the	DET
fnp-3459	35	50	brain	brain	NOUN
fnp-3459	35	51	,	,	PUNCT
fnp-3459	35	52	in	in	ADP
fnp-3459	35	53	the	the	DET
fnp-3459	35	54	rest	rest	NOUN
fnp-3459	35	55	of	of	ADP
fnp-3459	35	56	the	the	DET
fnp-3459	35	57	body	body	NOUN
fnp-3459	35	58	,	,	PUNCT
fnp-3459	35	59	there	there	PRON
fnp-3459	35	60	are	be	VERB
fnp-3459	35	61	several	several	ADJ
fnp-3459	35	62	other	other	ADJ
fnp-3459	35	63	lipoproteins	lipoprotein	NOUN
fnp-3459	35	64	that	that	PRON
fnp-3459	35	65	can	can	AUX
fnp-3459	35	66	fulfil	fulfil	VERB
fnp-3459	35	67	the	the	DET
fnp-3459	35	68	function	function	NOUN
fnp-3459	35	69	of	of	ADP
fnp-3459	35	70	cholesterol	cholesterol	NOUN
fnp-3459	35	71	transport	transport	NOUN
fnp-3459	35	72	in	in	ADP
fnp-3459	35	73	addition	addition	NOUN
fnp-3459	35	74	to	to	ADP
fnp-3459	35	75	apoe	apoe	NOUN
fnp-3459	35	76	,	,	PUNCT
fnp-3459	35	77	including	include	VERB
fnp-3459	35	78	apoa	apoa	NOUN
fnp-3459	35	79	which	which	PRON
fnp-3459	35	80	is	be	AUX
fnp-3459	35	81	synthesised	synthesise	VERB
fnp-3459	35	82	in	in	ADP
fnp-3459	35	83	the	the	DET
fnp-3459	35	84	liver	liver	NOUN
fnp-3459	35	85	[	[	X
fnp-3459	35	86	19	19	NUM
fnp-3459	35	87	]	]	PUNCT
fnp-3459	35	88	.	.	PUNCT
fnp-3459	36	1	apoa	apoa	NOUN
fnp-3459	36	2	-	-	PUNCT
fnp-3459	36	3	containing	contain	VERB
fnp-3459	36	4	lipoprotein	lipoprotein	ADJ
fnp-3459	36	5	particles	particle	NOUN
fnp-3459	36	6	are	be	AUX
fnp-3459	36	7	detectable	detectable	ADJ
fnp-3459	36	8	in	in	ADP
fnp-3459	36	9	the	the	DET
fnp-3459	36	10	csf	csf	NOUN
fnp-3459	36	11	but	but	CCONJ
fnp-3459	36	12	appear	appear	VERB
fnp-3459	36	13	to	to	PART
fnp-3459	36	14	be	be	AUX
fnp-3459	36	15	excluded	exclude	VERB
fnp-3459	36	16	from	from	ADP
fnp-3459	36	17	the	the	DET
fnp-3459	36	18	brain	brain	NOUN
fnp-3459	36	19	parenchyma	parenchyma	NOUN
fnp-3459	36	20	by	by	ADP
fnp-3459	36	21	the	the	DET
fnp-3459	36	22	blood	blood	NOUN
fnp-3459	36	23	-	-	PUNCT
fnp-3459	36	24	brain	brain	NOUN
fnp-3459	36	25	barrier	barrier	NOUN
fnp-3459	36	26	.	.	PUNCT
fnp-3459	37	1	consequently	consequently	ADV
fnp-3459	37	2	,	,	PUNCT
fnp-3459	37	3	the	the	DET
fnp-3459	37	4	cholesterol	cholesterol	NOUN
fnp-3459	37	5	required	require	VERB
fnp-3459	37	6	by	by	ADP
fnp-3459	37	7	neurons	neuron	NOUN
fnp-3459	37	8	is	be	AUX
fnp-3459	37	9	synthesised	synthesise	VERB
fnp-3459	37	10	within	within	ADP
fnp-3459	37	11	the	the	DET
fnp-3459	37	12	brain	brain	NOUN
fnp-3459	37	13	and	and	CCONJ
fnp-3459	37	14	delivered	deliver	VERB
fnp-3459	37	15	to	to	ADP
fnp-3459	37	16	neurons	neuron	NOUN
fnp-3459	37	17	by	by	ADP
fnp-3459	37	18	apoe	apoe	NOUN
fnp-3459	37	19	-	-	PUNCT
fnp-3459	37	20	containing	contain	VERB
fnp-3459	37	21	lipoprotein	lipoprotein	ADJ
fnp-3459	37	22	particles	particle	NOUN
fnp-3459	37	23	[	[	X
fnp-3459	37	24	20	20	NUM
fnp-3459	37	25	]	]	X
fnp-3459	38	1	[	[	X
fnp-3459	38	2	9	9	NUM
fnp-3459	38	3	,	,	PUNCT
fnp-3459	38	4	21	21	NUM
fnp-3459	38	5	]	]	PUNCT
fnp-3459	38	6	.	.	PUNCT
fnp-3459	39	1	lipoprotein	lipoprotein	ADJ
fnp-3459	39	2	particles	particle	NOUN
fnp-3459	39	3	become	become	VERB
fnp-3459	39	4	entrapped	entrap	VERB
fnp-3459	39	5	in	in	ADP
fnp-3459	39	6	the	the	DET
fnp-3459	39	7	ageing	age	VERB
fnp-3459	39	8	extracellular	extracellular	ADJ
fnp-3459	39	9	matrix	matrix	NOUN
fnp-3459	39	10	the	the	DET
fnp-3459	39	11	lipoprotein	lipoprotein	ADJ
fnp-3459	39	12	particles	particle	NOUN
fnp-3459	39	13	,	,	PUNCT
fnp-3459	39	14	which	which	PRON
fnp-3459	39	15	resemble	resemble	VERB
fnp-3459	39	16	the	the	DET
fnp-3459	39	17	high	high	ADJ
fnp-3459	39	18	-	-	PUNCT
fnp-3459	39	19	density	density	NOUN
fnp-3459	39	20	lipoproteins	lipoprotein	NOUN
fnp-3459	39	21	(	(	PUNCT
fnp-3459	39	22	hdl	hdl	NOUN
fnp-3459	39	23	)	)	PUNCT
fnp-3459	39	24	present	present	NOUN
fnp-3459	39	25	in	in	ADP
fnp-3459	39	26	the	the	DET
fnp-3459	39	27	bloodstream	bloodstream	NOUN
fnp-3459	39	28	,	,	PUNCT
fnp-3459	39	29	are	be	AUX
fnp-3459	39	30	in	in	ADP
fnp-3459	39	31	the	the	DET
fnp-3459	39	32	region	region	NOUN
fnp-3459	39	33	of	of	ADP
fnp-3459	39	34	11	11	NUM
fnp-3459	39	35	-	-	SYM
fnp-3459	39	36	20	20	NUM
fnp-3459	39	37	nm	nm	NOUN
fnp-3459	39	38	in	in	ADP
fnp-3459	39	39	diameter	diameter	NOUN
fnp-3459	40	1	[	[	X
fnp-3459	40	2	22	22	NUM
fnp-3459	40	3	]	]	PUNCT
fnp-3459	40	4	.	.	PUNCT
fnp-3459	41	1	in	in	ADP
fnp-3459	41	2	order	order	NOUN
fnp-3459	41	3	to	to	PART
fnp-3459	41	4	transport	transport	VERB
fnp-3459	41	5	cholesterol	cholesterol	NOUN
fnp-3459	41	6	to	to	ADP
fnp-3459	41	7	neurons	neuron	NOUN
fnp-3459	41	8	,	,	PUNCT
fnp-3459	41	9	they	they	PRON
fnp-3459	41	10	have	have	VERB
fnp-3459	41	11	to	to	PART
fnp-3459	41	12	travel	travel	VERB
fnp-3459	41	13	in	in	ADP
fnp-3459	41	14	the	the	DET
fnp-3459	41	15	extracellular	extracellular	ADJ
fnp-3459	41	16	space	space	NOUN
fnp-3459	41	17	in	in	ADP
fnp-3459	41	18	the	the	DET
fnp-3459	41	19	brain	brain	NOUN
fnp-3459	41	20	which	which	PRON
fnp-3459	41	21	itself	itself	PRON
fnp-3459	41	22	measures	measure	VERB
fnp-3459	41	23	only	only	ADV
fnp-3459	41	24	about	about	ADV
fnp-3459	41	25	40	40	NUM
fnp-3459	41	26	nm	nm	NOUN
fnp-3459	41	27	between	between	ADP
fnp-3459	41	28	adjacent	adjacent	ADJ
fnp-3459	41	29	cells	cell	NOUN
fnp-3459	41	30	[	[	X
fnp-3459	41	31	23	23	NUM
fnp-3459	41	32	]	]	PUNCT
fnp-3459	41	33	,	,	PUNCT
fnp-3459	41	34	below	below	ADP
fnp-3459	41	35	the	the	DET
fnp-3459	41	36	resolution	resolution	NOUN
fnp-3459	41	37	of	of	ADP
fnp-3459	41	38	light	light	ADJ
fnp-3459	41	39	microscopy	microscopy	NOUN
fnp-3459	41	40	.	.	PUNCT
fnp-3459	42	1	small	small	ADJ
fnp-3459	42	2	molecules	molecule	NOUN
fnp-3459	42	3	can	can	AUX
fnp-3459	42	4	pass	pass	VERB
fnp-3459	42	5	readily	readily	ADV
fnp-3459	42	6	,	,	PUNCT
fnp-3459	42	7	by	by	ADP
fnp-3459	42	8	diffusion	diffusion	NOUN
fnp-3459	42	9	and	and	CCONJ
fnp-3459	42	10	potentially	potentially	ADV
fnp-3459	42	11	by	by	ADP
fnp-3459	42	12	active	active	ADJ
fnp-3459	42	13	flow	flow	NOUN
fnp-3459	42	14	,	,	PUNCT
fnp-3459	42	15	through	through	ADP
fnp-3459	42	16	the	the	DET
fnp-3459	42	17	extracellular	extracellular	ADJ
fnp-3459	42	18	space	space	NOUN
fnp-3459	42	19	but	but	CCONJ
fnp-3459	42	20	diffusion	diffusion	NOUN
fnp-3459	42	21	even	even	ADV
fnp-3459	42	22	of	of	ADP
fnp-3459	42	23	conventional	conventional	ADJ
fnp-3459	42	24	macromolecules	macromolecule	NOUN
fnp-3459	42	25	much	much	ADV
fnp-3459	42	26	smaller	small	ADJ
fnp-3459	42	27	that	that	SCONJ
fnp-3459	42	28	lipoprotein	lipoprotein	ADJ
fnp-3459	42	29	particles	particle	NOUN
fnp-3459	42	30	is	be	AUX
fnp-3459	42	31	hindered	hinder	VERB
fnp-3459	42	32	,	,	PUNCT
fnp-3459	42	33	particularly	particularly	ADV
fnp-3459	42	34	in	in	ADP
fnp-3459	42	35	pathological	pathological	ADJ
fnp-3459	42	36	processes	process	NOUN
fnp-3459	42	37	such	such	ADJ
fnp-3459	42	38	as	as	ADP
fnp-3459	42	39	gliosis	gliosis	NOUN
fnp-3459	42	40	(	(	PUNCT
fnp-3459	42	41	activation	activation	NOUN
fnp-3459	42	42	of	of	ADP
fnp-3459	42	43	glial	glial	ADJ
fnp-3459	42	44	cells	cell	NOUN
fnp-3459	42	45	)	)	PUNCT
fnp-3459	43	1	[	[	X
fnp-3459	43	2	24	24	NUM
fnp-3459	43	3	]	]	PUNCT
fnp-3459	43	4	,	,	PUNCT
fnp-3459	43	5	which	which	PRON
fnp-3459	43	6	occurs	occur	VERB
fnp-3459	43	7	in	in	ADP
fnp-3459	43	8	association	association	NOUN
fnp-3459	43	9	with	with	ADP
fnp-3459	43	10	ageing	ageing	NOUN
fnp-3459	43	11	and	and	CCONJ
fnp-3459	43	12	the	the	DET
fnp-3459	43	13	neurodegeneration	neurodegeneration	NOUN
fnp-3459	43	14	in	in	ADP
fnp-3459	43	15	ad	ad	NOUN
fnp-3459	43	16	.	.	PUNCT
fnp-3459	44	1	an	an	DET
fnp-3459	44	2	additional	additional	ADJ
fnp-3459	44	3	complexity	complexity	NOUN
fnp-3459	44	4	is	be	AUX
fnp-3459	44	5	that	that	SCONJ
fnp-3459	44	6	the	the	DET
fnp-3459	44	7	extracellular	extracellular	ADJ
fnp-3459	44	8	space	space	NOUN
fnp-3459	44	9	resembles	resemble	VERB
fnp-3459	44	10	a	a	DET
fnp-3459	44	11	sponge	sponge	NOUN
fnp-3459	44	12	,	,	PUNCT
fnp-3459	44	13	containing	contain	VERB
fnp-3459	44	14	the	the	DET
fnp-3459	44	15	extracellular	extracellular	ADJ
fnp-3459	44	16	matrix	matrix	NOUN
fnp-3459	44	17	(	(	PUNCT
fnp-3459	44	18	ecm	ecm	PROPN
fnp-3459	44	19	)	)	PUNCT
fnp-3459	44	20	.	.	PUNCT
fnp-3459	45	1	in	in	ADP
fnp-3459	45	2	the	the	DET
fnp-3459	45	3	brain	brain	NOUN
fnp-3459	45	4	,	,	PUNCT
fnp-3459	45	5	the	the	DET
fnp-3459	45	6	ecm	ecm	PROPN
fnp-3459	45	7	is	be	AUX
fnp-3459	45	8	a	a	DET
fnp-3459	45	9	complex	complex	ADJ
fnp-3459	45	10	multimolecular	multimolecular	ADJ
fnp-3459	45	11	three	three	NUM
fnp-3459	45	12	-	-	PUNCT
fnp-3459	45	13	dimensional	dimensional	ADJ
fnp-3459	45	14	structure	structure	NOUN
fnp-3459	45	15	consisting	consist	VERB
fnp-3459	45	16	of	of	ADP
fnp-3459	45	17	proteoglycans	proteoglycan	NOUN
fnp-3459	45	18	/	/	SYM
fnp-3459	45	19	glycosaminoglycans	glycosaminoglycan	NOUN
fnp-3459	45	20	,	,	PUNCT
fnp-3459	45	21	proteins	protein	NOUN
fnp-3459	45	22	,	,	PUNCT
fnp-3459	45	23	proteinases	proteinase	NOUN
fnp-3459	45	24	,	,	PUNCT
fnp-3459	45	25	and	and	CCONJ
fnp-3459	45	26	cytokines	cytokine	VERB
fnp-3459	45	27	[	[	X
fnp-3459	45	28	25	25	NUM
fnp-3459	45	29	]	]	PUNCT
fnp-3459	45	30	.	.	PUNCT
fnp-3459	46	1	expression	expression	NOUN
fnp-3459	46	2	of	of	ADP
fnp-3459	46	3	collagen	collagen	NOUN
fnp-3459	46	4	iv	iv	NOUN
fnp-3459	46	5	,	,	PUNCT
fnp-3459	46	6	laminin	laminin	NOUN
fnp-3459	46	7	and	and	CCONJ
fnp-3459	46	8	fibronectin	fibronectin	NOUN
fnp-3459	46	9	is	be	AUX
fnp-3459	46	10	upregulated	upregulate	VERB
fnp-3459	46	11	in	in	ADP
fnp-3459	46	12	the	the	DET
fnp-3459	46	13	cerebral	cerebral	ADJ
fnp-3459	46	14	cortex	cortex	NOUN
fnp-3459	46	15	in	in	ADP
fnp-3459	46	16	early	early	ADJ
fnp-3459	46	17	ad	ad	NOUN
fnp-3459	46	18	.	.	PUNCT
fnp-3459	47	1	with	with	ADP
fnp-3459	47	2	ageing	age	VERB
fnp-3459	47	3	-	-	PUNCT
fnp-3459	47	4	related	relate	VERB
fnp-3459	47	5	changes	change	NOUN
fnp-3459	47	6	to	to	ADP
fnp-3459	47	7	the	the	DET
fnp-3459	47	8	extracellular	extracellular	ADJ
fnp-3459	47	9	matrix	matrix	NOUN
fnp-3459	47	10	,	,	PUNCT
fnp-3459	47	11	exacerbated	exacerbate	VERB
fnp-3459	47	12	by	by	ADP
fnp-3459	47	13	other	other	ADJ
fnp-3459	47	14	risk	risk	NOUN
fnp-3459	47	15	factors	factor	NOUN
fnp-3459	47	16	for	for	ADP
fnp-3459	47	17	ad	ad	NOUN
fnp-3459	47	18	(	(	PUNCT
fnp-3459	47	19	hypertension	hypertension	NOUN
fnp-3459	47	20	,	,	PUNCT
fnp-3459	47	21	diabetes	diabetes	NOUN
fnp-3459	47	22	,	,	PUNCT
fnp-3459	47	23	obesity	obesity	NOUN
fnp-3459	47	24	,	,	PUNCT
fnp-3459	47	25	inflammation	inflammation	NOUN
fnp-3459	47	26	and	and	CCONJ
fnp-3459	47	27	physical	physical	ADJ
fnp-3459	47	28	inactivity	inactivity	NOUN
fnp-3459	47	29	)	)	PUNCT
fnp-3459	47	30	,	,	PUNCT
fnp-3459	47	31	the	the	DET
fnp-3459	47	32	narrow	narrow	ADJ
fnp-3459	47	33	extracellular	extracellular	ADJ
fnp-3459	47	34	space	space	NOUN
fnp-3459	47	35	likely	likely	ADV
fnp-3459	47	36	becomes	becomes	AUX
fnp-3459	47	37	compromised	compromise	VERB
fnp-3459	47	38	(	(	PUNCT
fnp-3459	47	39	‘	'	PUNCT
fnp-3459	47	40	fibrosed	fibrose	VERB
fnp-3459	47	41	’	'	PUNCT
fnp-3459	47	42	)	)	PUNCT
fnp-3459	47	43	,	,	PUNCT
fnp-3459	47	44	impeding	impede	VERB
fnp-3459	47	45	the	the	DET
fnp-3459	47	46	movement	movement	NOUN
fnp-3459	47	47	of	of	ADP
fnp-3459	47	48	,	,	PUNCT
fnp-3459	47	49	and	and	CCONJ
fnp-3459	47	50	trapping	trap	VERB
fnp-3459	47	51	,	,	PUNCT
fnp-3459	47	52	lipoprotein	lipoprotein	ADJ
fnp-3459	47	53	particles	particle	NOUN
fnp-3459	47	54	in	in	ADP
fnp-3459	47	55	between	between	ADP
fnp-3459	47	56	cells	cell	NOUN
fnp-3459	47	57	.	.	PUNCT
fnp-3459	48	1	interestingly	interestingly	ADV
fnp-3459	48	2	,	,	PUNCT
fnp-3459	48	3	oxidative	oxidative	ADJ
fnp-3459	48	4	modification	modification	NOUN
fnp-3459	48	5	of	of	ADP
fnp-3459	48	6	plasma	plasma	NOUN
fnp-3459	48	7	lipoproteins	lipoprotein	NOUN
fnp-3459	48	8	is	be	AUX
fnp-3459	48	9	one	one	NUM
fnp-3459	48	10	of	of	ADP
fnp-3459	48	11	the	the	DET
fnp-3459	48	12	earliest	early	ADJ
fnp-3459	48	13	steps	step	NOUN
fnp-3459	48	14	in	in	ADP
fnp-3459	48	15	the	the	DET
fnp-3459	48	16	development	development	NOUN
fnp-3459	48	17	of	of	ADP
fnp-3459	48	18	atherosclerosis	atherosclerosis	NOUN
fnp-3459	48	19	,	,	PUNCT
fnp-3459	48	20	involving	involve	VERB
fnp-3459	48	21	accumulation	accumulation	NOUN
fnp-3459	48	22	of	of	ADP
fnp-3459	48	23	lipoprotein	lipoprotein	ADJ
fnp-3459	48	24	particles	particle	NOUN
fnp-3459	48	25	in	in	ADP
fnp-3459	48	26	the	the	DET
fnp-3459	48	27	vessel	vessel	NOUN
fnp-3459	48	28	wall	wall	NOUN
fnp-3459	48	29	provoking	provoke	VERB
fnp-3459	48	30	inflammatory	inflammatory	ADJ
fnp-3459	48	31	reaction	reaction	NOUN
fnp-3459	48	32	[	[	X
fnp-3459	48	33	26	26	NUM
fnp-3459	48	34	]	]	PUNCT
fnp-3459	48	35	.	.	PUNCT
fnp-3459	49	1	in	in	ADP
fnp-3459	49	2	ad	ad	NOUN
fnp-3459	49	3	patients	patient	NOUN
fnp-3459	49	4	,	,	PUNCT
fnp-3459	49	5	there	there	PRON
fnp-3459	49	6	is	be	VERB
fnp-3459	49	7	evidence	evidence	NOUN
fnp-3459	49	8	of	of	ADP
fnp-3459	49	9	greater	great	ADJ
fnp-3459	49	10	oxidation	oxidation	NOUN
fnp-3459	49	11	of	of	ADP
fnp-3459	49	12	plasma	plasma	NOUN
fnp-3459	49	13	and	and	CCONJ
fnp-3459	49	14	csf	csf	ADJ
fnp-3459	49	15	lipoproteins	lipoprotein	NOUN
fnp-3459	49	16	[	[	X
fnp-3459	49	17	26	26	NUM
fnp-3459	49	18	]	]	PUNCT
fnp-3459	49	19	and	and	CCONJ
fnp-3459	49	20	this	this	PRON
fnp-3459	49	21	could	could	AUX
fnp-3459	49	22	conceivably	conceivably	ADV
fnp-3459	49	23	further	far	ADV
fnp-3459	49	24	impair	impair	VERB
fnp-3459	49	25	the	the	DET
fnp-3459	49	26	passage	passage	NOUN
fnp-3459	49	27	of	of	ADP
fnp-3459	49	28	lipoprotein	lipoprotein	ADJ
fnp-3459	49	29	particles	particle	NOUN
fnp-3459	49	30	through	through	ADP
fnp-3459	49	31	the	the	DET
fnp-3459	49	32	extracellular	extracellular	ADJ
fnp-3459	49	33	space	space	NOUN
fnp-3459	49	34	in	in	ADP
fnp-3459	49	35	the	the	DET
fnp-3459	49	36	brain	brain	NOUN
fnp-3459	49	37	.	.	PUNCT
fnp-3459	50	1	consequently	consequently	ADV
fnp-3459	50	2	,	,	PUNCT
fnp-3459	50	3	the	the	DET
fnp-3459	50	4	apoe	apoe	NOUN
fnp-3459	50	5	-	-	PUNCT
fnp-3459	50	6	mediated	mediate	VERB
fnp-3459	50	7	system	system	NOUN
fnp-3459	50	8	for	for	ADP
fnp-3459	50	9	transporting	transport	VERB
fnp-3459	50	10	cholesterol	cholesterol	NOUN
fnp-3459	50	11	and	and	CCONJ
fnp-3459	50	12	lipids	lipid	NOUN
fnp-3459	50	13	from	from	ADP
fnp-3459	50	14	glial	glial	ADJ
fnp-3459	50	15	cells	cell	NOUN
fnp-3459	50	16	to	to	ADP
fnp-3459	50	17	neurons	neuron	NOUN
fnp-3459	50	18	in	in	ADP
fnp-3459	50	19	the	the	DET
fnp-3459	50	20	brain	brain	NOUN
fnp-3459	50	21	is	be	AUX
fnp-3459	50	22	unique	unique	ADJ
fnp-3459	50	23	,	,	PUNCT
fnp-3459	50	24	crucial	crucial	ADJ
fnp-3459	50	25	for	for	ADP
fnp-3459	50	26	neuronal	neuronal	ADJ
fnp-3459	50	27	function	function	NOUN
fnp-3459	50	28	and	and	CCONJ
fnp-3459	50	29	plasticity	plasticity	NOUN
fnp-3459	50	30	and	and	CCONJ
fnp-3459	50	31	vulnerable	vulnerable	ADJ
fnp-3459	50	32	to	to	ADP
fnp-3459	50	33	age	age	NOUN
fnp-3459	50	34	-	-	PUNCT
fnp-3459	50	35	related	relate	VERB
fnp-3459	50	36	failure	failure	NOUN
fnp-3459	50	37	(	(	PUNCT
fnp-3459	50	38	figure	figure	NOUN
fnp-3459	50	39	1	1	NUM
fnp-3459	50	40	)	)	PUNCT
fnp-3459	50	41	.	.	PUNCT
fnp-3459	51	1	it	it	PRON
fnp-3459	51	2	is	be	AUX
fnp-3459	51	3	proposed	propose	VERB
fnp-3459	51	4	that	that	SCONJ
fnp-3459	51	5	this	this	DET
fnp-3459	51	6	results	result	VERB
fnp-3459	51	7	in	in	ADP
fnp-3459	51	8	a	a	DET
fnp-3459	51	9	number	number	NOUN
fnp-3459	51	10	of	of	ADP
fnp-3459	51	11	consequences	consequence	NOUN
fnp-3459	51	12	leading	lead	VERB
fnp-3459	51	13	to	to	ADP
fnp-3459	51	14	the	the	DET
fnp-3459	51	15	key	key	ADJ
fnp-3459	51	16	features	feature	NOUN
fnp-3459	51	17	of	of	ADP
fnp-3459	51	18	ad	ad	NOUN
fnp-3459	51	19	pathophysiology	pathophysiology	NOUN
fnp-3459	51	20	as	as	SCONJ
fnp-3459	51	21	follows	follow	VERB
fnp-3459	51	22	.	.	PUNCT
fnp-3459	52	1	figure	figure	NOUN
fnp-3459	52	2	1	1	NUM
fnp-3459	52	3	.	.	PUNCT
fnp-3459	53	1	entrapment	entrapment	NOUN
fnp-3459	53	2	of	of	ADP
fnp-3459	53	3	lipoprotein	lipoprotein	ADJ
fnp-3459	53	4	particles	particle	NOUN
fnp-3459	53	5	in	in	ADP
fnp-3459	53	6	the	the	DET
fnp-3459	53	7	brain	brain	NOUN
fnp-3459	53	8	causes	cause	VERB
fnp-3459	53	9	alzheimer	alzheimer	PROPN
fnp-3459	53	10	’s	’s	PART
fnp-3459	53	11	disease	disease	NOUN
fnp-3459	53	12	.	.	PUNCT
fnp-3459	54	1	lipoprotein	lipoprotein	ADJ
fnp-3459	54	2	particles	particle	NOUN
fnp-3459	54	3	transport	transport	VERB
fnp-3459	54	4	cholesterol	cholesterol	NOUN
fnp-3459	54	5	from	from	ADP
fnp-3459	54	6	glial	glial	ADJ
fnp-3459	54	7	cells	cell	NOUN
fnp-3459	54	8	,	,	PUNCT
fnp-3459	54	9	where	where	SCONJ
fnp-3459	54	10	it	it	PRON
fnp-3459	54	11	is	be	AUX
fnp-3459	54	12	synthesised	synthesise	VERB
fnp-3459	54	13	,	,	PUNCT
fnp-3459	54	14	to	to	ADP
fnp-3459	54	15	neurons	neuron	NOUN
fnp-3459	54	16	which	which	PRON
fnp-3459	54	17	require	require	VERB
fnp-3459	54	18	cholesterol	cholesterol	NOUN
fnp-3459	54	19	for	for	ADP
fnp-3459	54	20	synaptic	synaptic	ADJ
fnp-3459	54	21	plasticity	plasticity	NOUN
fnp-3459	54	22	.	.	PUNCT
fnp-3459	55	1	the	the	DET
fnp-3459	55	2	lipoprotein	lipoprotein	ADJ
fnp-3459	55	3	particles	particle	NOUN
fnp-3459	55	4	have	have	VERB
fnp-3459	55	5	a	a	DET
fnp-3459	55	6	cholesterol	cholesterol	NOUN
fnp-3459	55	7	-	-	PUNCT
fnp-3459	55	8	containing	contain	VERB
fnp-3459	55	9	hydrophobic	hydrophobic	NOUN
fnp-3459	55	10	core	core	NOUN
fnp-3459	55	11	,	,	PUNCT
fnp-3459	55	12	in	in	ADP
fnp-3459	55	13	which	which	PRON
fnp-3459	55	14	aβ	aβ	NOUN
fnp-3459	55	15	is	be	AUX
fnp-3459	55	16	solubilised	solubilise	VERB
fnp-3459	55	17	,	,	PUNCT
fnp-3459	55	18	and	and	CCONJ
fnp-3459	55	19	a	a	DET
fnp-3459	55	20	hydrophilic	hydrophilic	ADJ
fnp-3459	55	21	surface	surface	NOUN
fnp-3459	55	22	containing	contain	VERB
fnp-3459	55	23	apolipoprotein	apolipoprotein	ADJ
fnp-3459	55	24	e.	e.	PROPN
fnp-3459	55	25	receptors	receptor	NOUN
fnp-3459	55	26	for	for	ADP
fnp-3459	55	27	apoe	apoe	NOUN
fnp-3459	55	28	on	on	ADP
fnp-3459	55	29	the	the	DET
fnp-3459	55	30	neuronal	neuronal	ADJ
fnp-3459	55	31	cell	cell	NOUN
fnp-3459	55	32	membrane	membrane	NOUN
fnp-3459	55	33	determine	determine	VERB
fnp-3459	55	34	the	the	DET
fnp-3459	55	35	destination	destination	NOUN
fnp-3459	55	36	of	of	ADP
fnp-3459	55	37	the	the	DET
fnp-3459	55	38	particles	particle	NOUN
fnp-3459	55	39	.	.	PUNCT
fnp-3459	56	1	the	the	DET
fnp-3459	56	2	lipoprotein	lipoprotein	ADJ
fnp-3459	56	3	particles	particle	NOUN
fnp-3459	56	4	must	must	AUX
fnp-3459	56	5	navigate	navigate	VERB
fnp-3459	56	6	the	the	DET
fnp-3459	56	7	extracellular	extracellular	ADJ
fnp-3459	56	8	space	space	NOUN
fnp-3459	56	9	to	to	PART
fnp-3459	56	10	reach	reach	VERB
fnp-3459	56	11	the	the	DET
fnp-3459	56	12	neurons	neuron	NOUN
fnp-3459	56	13	,	,	PUNCT
fnp-3459	56	14	a	a	DET
fnp-3459	56	15	narrow	narrow	ADJ
fnp-3459	56	16	cleft	cleft	NOUN
fnp-3459	56	17	barely	barely	ADV
fnp-3459	56	18	wider	wide	ADJ
fnp-3459	56	19	than	than	ADP
fnp-3459	56	20	the	the	DET
fnp-3459	56	21	particles	particle	NOUN
fnp-3459	56	22	themselves	themselves	PRON
fnp-3459	56	23	.	.	PUNCT
fnp-3459	57	1	as	as	SCONJ
fnp-3459	57	2	the	the	DET
fnp-3459	57	3	extracellular	extracellular	ADJ
fnp-3459	57	4	matrix	matrix	NOUN
fnp-3459	57	5	ages	age	NOUN
fnp-3459	57	6	,	,	PUNCT
fnp-3459	57	7	lipoprotein	lipoprotein	ADJ
fnp-3459	57	8	particles	particle	NOUN
fnp-3459	57	9	become	become	VERB
fnp-3459	57	10	trapped	trap	VERB
fnp-3459	57	11	between	between	ADP
fnp-3459	57	12	cells	cell	NOUN
fnp-3459	57	13	and	and	CCONJ
fnp-3459	57	14	this	this	DET
fnp-3459	57	15	primary	primary	ADJ
fnp-3459	57	16	abnormality	abnormality	NOUN
fnp-3459	57	17	results	result	NOUN
fnp-3459	57	18	in	in	ADP
fnp-3459	57	19	reduced	reduced	ADJ
fnp-3459	57	20	delivery	delivery	NOUN
fnp-3459	57	21	of	of	ADP
fnp-3459	57	22	cholesterol	cholesterol	NOUN
fnp-3459	57	23	to	to	ADP
fnp-3459	57	24	neurons	neuron	NOUN
fnp-3459	57	25	leading	lead	VERB
fnp-3459	57	26	to	to	ADP
fnp-3459	57	27	impaired	impaired	ADJ
fnp-3459	57	28	synaptic	synaptic	ADJ
fnp-3459	57	29	plasticity	plasticity	NOUN
fnp-3459	57	30	,	,	PUNCT
fnp-3459	57	31	crucial	crucial	ADJ
fnp-3459	57	32	for	for	ADP
fnp-3459	57	33	learning	learning	NOUN
fnp-3459	57	34	and	and	CCONJ
fnp-3459	57	35	memory	memory	NOUN
fnp-3459	57	36	.	.	PUNCT
fnp-3459	58	1	impaired	impaired	ADJ
fnp-3459	58	2	movement	movement	NOUN
fnp-3459	58	3	of	of	ADP
fnp-3459	58	4	lipoprotein	lipoprotein	ADJ
fnp-3459	58	5	particles	particle	NOUN
fnp-3459	58	6	in	in	ADP
fnp-3459	58	7	the	the	DET
fnp-3459	58	8	extracellular	extracellular	ADJ
fnp-3459	58	9	space	space	NOUN
fnp-3459	58	10	in	in	ADP
fnp-3459	58	11	the	the	DET
fnp-3459	58	12	brain	brain	NOUN
fnp-3459	58	13	in	in	ADP
fnp-3459	58	14	ageing	ageing	NOUN
fnp-3459	58	15	is	be	AUX
fnp-3459	58	16	central	central	ADJ
fnp-3459	58	17	to	to	PART
fnp-3459	58	18	and	and	CCONJ
fnp-3459	58	19	causes	cause	VERB
fnp-3459	58	20	all	all	DET
fnp-3459	58	21	the	the	DET
fnp-3459	58	22	key	key	ADJ
fnp-3459	58	23	pathophysiological	pathophysiological	ADJ
fnp-3459	58	24	features	feature	NOUN
fnp-3459	58	25	of	of	ADP
fnp-3459	58	26	alzheimer	alzheimer	PROPN
fnp-3459	58	27	’s	’s	PART
fnp-3459	58	28	disease	disease	NOUN
fnp-3459	58	29	:	:	PUNCT
fnp-3459	58	30	degeneration	degeneration	NOUN
fnp-3459	58	31	of	of	ADP
fnp-3459	58	32	entrapped	entrapped	ADJ
fnp-3459	58	33	lipoprotein	lipoprotein	ADJ
fnp-3459	58	34	particles	particle	NOUN
fnp-3459	58	35	releases	release	NOUN
fnp-3459	58	36	aβ	aβ	VERB
fnp-3459	58	37	which	which	PRON
fnp-3459	58	38	aggregates	aggregate	VERB
fnp-3459	58	39	in	in	ADP
fnp-3459	58	40	the	the	DET
fnp-3459	58	41	aqueous	aqueous	ADJ
fnp-3459	58	42	environment	environment	NOUN
fnp-3459	58	43	of	of	ADP
fnp-3459	58	44	the	the	DET
fnp-3459	58	45	extracellular	extracellular	ADJ
fnp-3459	58	46	space	space	NOUN
fnp-3459	58	47	;	;	PUNCT
fnp-3459	58	48	a	a	DET
fnp-3459	58	49	microglial	microglial	ADJ
fnp-3459	58	50	reaction	reaction	NOUN
fnp-3459	58	51	to	to	ADP
fnp-3459	58	52	the	the	DET
fnp-3459	58	53	aβ	aβ	NOUN
fnp-3459	58	54	results	result	NOUN
fnp-3459	58	55	in	in	ADP
fnp-3459	58	56	secretion	secretion	NOUN
fnp-3459	58	57	of	of	ADP
fnp-3459	58	58	neurotoxic	neurotoxic	ADJ
fnp-3459	58	59	substances	substance	NOUN
fnp-3459	58	60	;	;	PUNCT
fnp-3459	58	61	neuronal	neuronal	ADJ
fnp-3459	58	62	cholesterol	cholesterol	NOUN
fnp-3459	58	63	deficiency	deficiency	NOUN
fnp-3459	58	64	causes	cause	VERB
fnp-3459	58	65	intraneuronal	intraneuronal	ADJ
fnp-3459	58	66	tau	tau	PROPN
fnp-3459	58	67	accumulation	accumulation	NOUN
fnp-3459	58	68	.	.	PUNCT
fnp-3459	59	1	[	[	X
fnp-3459	59	2	artwork	artwork	NOUN
fnp-3459	59	3	by	by	ADP
fnp-3459	59	4	dr	dr	PROPN
fnp-3459	59	5	jennifer	jennifer	PROPN
fnp-3459	59	6	m	m	PROPN
fnp-3459	59	7	dewing	dewe	VERB
fnp-3459	59	8	]	]	PUNCT
fnp-3459	59	9	entrapment	entrapment	NOUN
fnp-3459	59	10	of	of	ADP
fnp-3459	59	11	lipoprotein	lipoprotein	ADJ
fnp-3459	59	12	particles	particle	NOUN
fnp-3459	59	13	can	can	AUX
fnp-3459	59	14	explain	explain	VERB
fnp-3459	59	15	the	the	DET
fnp-3459	59	16	key	key	ADJ
fnp-3459	59	17	features	feature	NOUN
fnp-3459	59	18	of	of	ADP
fnp-3459	59	19	alzheimer	alzheimer	PROPN
fnp-3459	59	20	’s	’s	PART
fnp-3459	59	21	disease	disease	NOUN
fnp-3459	59	22	aβ	aβ	ADP
fnp-3459	59	23	deposition	deposition	NOUN
fnp-3459	59	24	in	in	ADP
fnp-3459	59	25	the	the	DET
fnp-3459	59	26	parenchyma	parenchyma	NOUN
fnp-3459	59	27	as	as	ADP
fnp-3459	59	28	plaques	plaque	NOUN
fnp-3459	59	29	:	:	PUNCT
fnp-3459	59	30	aβ	aβ	PRON
fnp-3459	59	31	peptide	peptide	NOUN
fnp-3459	59	32	is	be	AUX
fnp-3459	59	33	notoriously	notoriously	ADV
fnp-3459	59	34	insoluble	insoluble	ADJ
fnp-3459	59	35	in	in	ADP
fnp-3459	59	36	an	an	DET
fnp-3459	59	37	aqueous	aqueous	ADJ
fnp-3459	59	38	environment	environment	NOUN
fnp-3459	59	39	,	,	PUNCT
fnp-3459	59	40	but	but	CCONJ
fnp-3459	59	41	it	it	PRON
fnp-3459	59	42	is	be	AUX
fnp-3459	59	43	lipid	lipid	NOUN
fnp-3459	59	44	soluble	soluble	ADJ
fnp-3459	59	45	and	and	CCONJ
fnp-3459	59	46	is	be	AUX
fnp-3459	59	47	transported	transport	VERB
fnp-3459	59	48	in	in	ADP
fnp-3459	59	49	the	the	DET
fnp-3459	59	50	hydrophobic	hydrophobic	NOUN
fnp-3459	59	51	core	core	NOUN
fnp-3459	59	52	of	of	ADP
fnp-3459	59	53	lipoprotein	lipoprotein	ADJ
fnp-3459	59	54	particles	particle	NOUN
fnp-3459	59	55	[	[	X
fnp-3459	59	56	27	27	NUM
fnp-3459	59	57	-	-	SYM
fnp-3459	59	58	30	30	NUM
fnp-3459	59	59	]	]	PUNCT
fnp-3459	59	60	.	.	PUNCT
fnp-3459	60	1	therefore	therefore	ADV
fnp-3459	60	2	,	,	PUNCT
fnp-3459	60	3	trapping	trap	VERB
fnp-3459	60	4	lipoprotein	lipoprotein	ADJ
fnp-3459	60	5	particles	particle	NOUN
fnp-3459	60	6	would	would	AUX
fnp-3459	60	7	immobilise	immobilise	VERB
fnp-3459	60	8	aβ	aβ	NOUN
fnp-3459	60	9	in	in	ADP
fnp-3459	60	10	the	the	DET
fnp-3459	60	11	extracellular	extracellular	ADJ
fnp-3459	60	12	space	space	NOUN
fnp-3459	60	13	.	.	PUNCT
fnp-3459	61	1	as	as	SCONJ
fnp-3459	61	2	the	the	DET
fnp-3459	61	3	trapped	trap	VERB
fnp-3459	61	4	particles	particle	NOUN
fnp-3459	61	5	degrade	degrade	VERB
fnp-3459	61	6	and	and	CCONJ
fnp-3459	61	7	rupture	rupture	NOUN
fnp-3459	61	8	,	,	PUNCT
fnp-3459	61	9	we	we	PRON
fnp-3459	61	10	propose	propose	VERB
fnp-3459	61	11	they	they	PRON
fnp-3459	61	12	release	release	VERB
fnp-3459	61	13	aβ	aβ	PRON
fnp-3459	61	14	peptide	peptide	NOUN
fnp-3459	61	15	into	into	ADP
fnp-3459	61	16	the	the	DET
fnp-3459	61	17	surrounding	surround	VERB
fnp-3459	61	18	aqueous	aqueous	ADJ
fnp-3459	61	19	environment	environment	NOUN
fnp-3459	61	20	where	where	SCONJ
fnp-3459	61	21	it	it	PRON
fnp-3459	61	22	aggregates	aggregate	VERB
fnp-3459	61	23	,	,	PUNCT
fnp-3459	61	24	initiating	initiate	VERB
fnp-3459	61	25	the	the	DET
fnp-3459	61	26	formation	formation	NOUN
fnp-3459	61	27	of	of	ADP
fnp-3459	61	28	extracellular	extracellular	ADJ
fnp-3459	61	29	aβ	aβ	NOUN
fnp-3459	61	30	plaques	plaque	NOUN
fnp-3459	61	31	.	.	PUNCT
fnp-3459	62	1	co	co	NOUN
fnp-3459	62	2	-	-	NOUN
fnp-3459	62	3	localisation	localisation	NOUN
fnp-3459	62	4	of	of	ADP
fnp-3459	62	5	apoe	apoe	NOUN
fnp-3459	62	6	with	with	ADP
fnp-3459	62	7	aβ	aβ	ADP
fnp-3459	62	8	plaques	plaque	NOUN
fnp-3459	62	9	is	be	AUX
fnp-3459	62	10	consistent	consistent	ADJ
fnp-3459	62	11	with	with	ADP
fnp-3459	62	12	the	the	DET
fnp-3459	62	13	origin	origin	NOUN
fnp-3459	62	14	of	of	ADP
fnp-3459	62	15	the	the	DET
fnp-3459	62	16	aβ	aβ	NOUN
fnp-3459	62	17	as	as	ADP
fnp-3459	62	18	being	be	AUX
fnp-3459	62	19	from	from	ADP
fnp-3459	62	20	apoe	apoe	NOUN
fnp-3459	62	21	-	-	PUNCT
fnp-3459	62	22	containing	contain	VERB
fnp-3459	62	23	lipoprotein	lipoprotein	ADJ
fnp-3459	62	24	particles	particle	NOUN
fnp-3459	62	25	[	[	X
fnp-3459	62	26	31	31	NUM
fnp-3459	62	27	]	]	PUNCT
fnp-3459	62	28	.	.	PUNCT
fnp-3459	63	1	immunohistochemistry	immunohistochemistry	NOUN
fnp-3459	63	2	for	for	ADP
fnp-3459	63	3	aβ	aβ	NOUN
fnp-3459	63	4	on	on	ADP
fnp-3459	63	5	semi	semi	ADJ
fnp-3459	63	6	-	-	ADJ
fnp-3459	63	7	thin	thin	ADJ
fnp-3459	63	8	sections	section	NOUN
fnp-3459	63	9	(	(	PUNCT
fnp-3459	63	10	1μm	1μm	ADV
fnp-3459	63	11	)	)	PUNCT
fnp-3459	63	12	shows	show	VERB
fnp-3459	63	13	that	that	SCONJ
fnp-3459	63	14	diffuse	diffuse	NOUN
fnp-3459	63	15	plaques	plaque	NOUN
fnp-3459	63	16	,	,	PUNCT
fnp-3459	63	17	usually	usually	ADV
fnp-3459	63	18	interpreted	interpret	VERB
fnp-3459	63	19	as	as	ADP
fnp-3459	63	20	the	the	DET
fnp-3459	63	21	earliest	early	ADJ
fnp-3459	63	22	stage	stage	NOUN
fnp-3459	63	23	of	of	ADP
fnp-3459	63	24	aβ	aβ	PRON
fnp-3459	63	25	deposition	deposition	NOUN
fnp-3459	63	26	,	,	PUNCT
fnp-3459	63	27	are	be	AUX
fnp-3459	63	28	formed	form	VERB
fnp-3459	63	29	from	from	ADP
fnp-3459	63	30	a	a	DET
fnp-3459	63	31	cluster	cluster	NOUN
fnp-3459	63	32	of	of	ADP
fnp-3459	63	33	dot	dot	NOUN
fnp-3459	63	34	-	-	PUNCT
fnp-3459	63	35	like	like	ADJ
fnp-3459	63	36	structures	structure	NOUN
fnp-3459	63	37	[	[	X
fnp-3459	63	38	32	32	NUM
fnp-3459	63	39	]	]	PUNCT
fnp-3459	63	40	,	,	PUNCT
fnp-3459	63	41	and	and	CCONJ
fnp-3459	63	42	electron	electron	NOUN
fnp-3459	63	43	microscopy	microscopy	NOUN
fnp-3459	63	44	shows	show	VERB
fnp-3459	63	45	small	small	ADJ
fnp-3459	63	46	vesicles	vesicle	NOUN
fnp-3459	63	47	associated	associate	VERB
fnp-3459	63	48	with	with	ADP
fnp-3459	63	49	amyloid	amyloid	NOUN
fnp-3459	63	50	fibrils	fibril	NOUN
fnp-3459	63	51	in	in	ADP
fnp-3459	63	52	the	the	DET
fnp-3459	63	53	extracellular	extracellular	ADJ
fnp-3459	63	54	space	space	NOUN
fnp-3459	63	55	[	[	X
fnp-3459	63	56	32	32	NUM
fnp-3459	63	57	]	]	PUNCT
fnp-3459	63	58	.	.	PUNCT
fnp-3459	64	1	in	in	ADP
fnp-3459	64	2	the	the	DET
fnp-3459	64	3	context	context	NOUN
fnp-3459	64	4	of	of	ADP
fnp-3459	64	5	the	the	DET
fnp-3459	64	6	current	current	ADJ
fnp-3459	64	7	hypothesis	hypothesis	NOUN
fnp-3459	64	8	,	,	PUNCT
fnp-3459	64	9	it	it	PRON
fnp-3459	64	10	is	be	AUX
fnp-3459	64	11	intriguing	intriguing	ADJ
fnp-3459	64	12	to	to	PART
fnp-3459	64	13	speculate	speculate	VERB
fnp-3459	64	14	that	that	SCONJ
fnp-3459	64	15	these	these	PRON
fnp-3459	64	16	might	might	AUX
fnp-3459	64	17	be	be	AUX
fnp-3459	64	18	entrapped	entrap	VERB
fnp-3459	64	19	lipoprotein	lipoprotein	ADJ
fnp-3459	64	20	particles	particle	NOUN
fnp-3459	64	21	from	from	ADP
fnp-3459	64	22	which	which	PRON
fnp-3459	64	23	the	the	DET
fnp-3459	64	24	amyloid	amyloid	NOUN
fnp-3459	64	25	has	have	AUX
fnp-3459	64	26	originated	originate	VERB
fnp-3459	64	27	.	.	PUNCT
fnp-3459	65	1	app	app	NOUN
fnp-3459	65	2	transgenic	transgenic	NOUN
fnp-3459	65	3	mice	mouse	NOUN
fnp-3459	65	4	,	,	PUNCT
fnp-3459	65	5	over	over	ADP
fnp-3459	65	6	-	-	PUNCT
fnp-3459	65	7	expressing	express	VERB
fnp-3459	65	8	the	the	DET
fnp-3459	65	9	v717f	v717f	PROPN
fnp-3459	65	10	human	human	ADJ
fnp-3459	65	11	amyloid	amyloid	NOUN
fnp-3459	65	12	precursor	precursor	NOUN
fnp-3459	65	13	protein	protein	NOUN
fnp-3459	65	14	,	,	PUNCT
fnp-3459	65	15	develop	develop	VERB
fnp-3459	65	16	aβ	aβ	PRON
fnp-3459	65	17	plaques	plaque	NOUN
fnp-3459	65	18	as	as	SCONJ
fnp-3459	65	19	they	they	PRON
fnp-3459	65	20	age	age	VERB
fnp-3459	65	21	.	.	PUNCT
fnp-3459	66	1	interestingly	interestingly	ADV
fnp-3459	66	2	,	,	PUNCT
fnp-3459	66	3	when	when	SCONJ
fnp-3459	66	4	crossed	cross	VERB
fnp-3459	66	5	with	with	ADP
fnp-3459	66	6	apoe	apoe	NOUN
fnp-3459	66	7	knock	knock	VERB
fnp-3459	66	8	out	out	ADP
fnp-3459	66	9	mice	mouse	NOUN
fnp-3459	66	10	so	so	SCONJ
fnp-3459	66	11	that	that	SCONJ
fnp-3459	66	12	they	they	PRON
fnp-3459	66	13	lack	lack	VERB
fnp-3459	66	14	apoe	apoe	ADV
fnp-3459	66	15	,	,	PUNCT
fnp-3459	66	16	these	these	DET
fnp-3459	66	17	mice	mouse	NOUN
fnp-3459	66	18	do	do	AUX
fnp-3459	66	19	not	not	PART
fnp-3459	66	20	accumulate	accumulate	VERB
fnp-3459	66	21	plaques	plaque	NOUN
fnp-3459	66	22	[	[	X
fnp-3459	66	23	33	33	NUM
fnp-3459	66	24	]	]	PUNCT
fnp-3459	66	25	.	.	PUNCT
fnp-3459	67	1	this	this	DET
fnp-3459	67	2	finding	finding	NOUN
fnp-3459	67	3	indicates	indicate	VERB
fnp-3459	67	4	that	that	SCONJ
fnp-3459	67	5	apoe	apoe	NOUN
fnp-3459	67	6	is	be	AUX
fnp-3459	67	7	essential	essential	ADJ
fnp-3459	67	8	for	for	ADP
fnp-3459	67	9	the	the	DET
fnp-3459	67	10	deposition	deposition	NOUN
fnp-3459	67	11	of	of	ADP
fnp-3459	67	12	aβ	aβ	DET
fnp-3459	67	13	plaques	plaque	NOUN
fnp-3459	67	14	,	,	PUNCT
fnp-3459	67	15	supporting	support	VERB
fnp-3459	67	16	the	the	DET
fnp-3459	67	17	mechanism	mechanism	NOUN
fnp-3459	67	18	we	we	PRON
fnp-3459	67	19	propose	propose	VERB
fnp-3459	67	20	.	.	PUNCT
fnp-3459	68	1	with	with	ADP
fnp-3459	68	2	ageing	age	VERB
fnp-3459	68	3	,	,	PUNCT
fnp-3459	68	4	the	the	DET
fnp-3459	68	5	primary	primary	ADJ
fnp-3459	68	6	risk	risk	NOUN
fnp-3459	68	7	factor	factor	NOUN
fnp-3459	68	8	for	for	ADP
fnp-3459	68	9	ad	ad	NOUN
fnp-3459	68	10	,	,	PUNCT
fnp-3459	68	11	the	the	DET
fnp-3459	68	12	human	human	ADJ
fnp-3459	68	13	brain	brain	NOUN
fnp-3459	68	14	decreases	decrease	VERB
fnp-3459	68	15	in	in	ADP
fnp-3459	68	16	weight	weight	NOUN
fnp-3459	68	17	and	and	CCONJ
fnp-3459	68	18	size	size	NOUN
fnp-3459	68	19	with	with	ADP
fnp-3459	68	20	an	an	DET
fnp-3459	68	21	overall	overall	ADJ
fnp-3459	68	22	decline	decline	NOUN
fnp-3459	68	23	in	in	ADP
fnp-3459	68	24	cortical	cortical	ADJ
fnp-3459	68	25	cholesterol	cholesterol	NOUN
fnp-3459	68	26	that	that	PRON
fnp-3459	68	27	accelerates	accelerate	VERB
fnp-3459	68	28	from	from	ADP
fnp-3459	68	29	the	the	DET
fnp-3459	68	30	age	age	NOUN
fnp-3459	68	31	of	of	ADP
fnp-3459	68	32	80	80	NUM
fnp-3459	68	33	[	[	SYM
fnp-3459	68	34	34	34	NUM
fnp-3459	68	35	,	,	PUNCT
fnp-3459	68	36	35	35	NUM
fnp-3459	68	37	]	]	PUNCT
fnp-3459	68	38	.	.	PUNCT
fnp-3459	69	1	this	this	PRON
fnp-3459	69	2	is	be	AUX
fnp-3459	69	3	consistent	consistent	ADJ
fnp-3459	69	4	with	with	ADP
fnp-3459	69	5	age	age	NOUN
fnp-3459	69	6	-	-	PUNCT
fnp-3459	69	7	associated	associate	VERB
fnp-3459	69	8	entrapment	entrapment	NOUN
fnp-3459	69	9	of	of	ADP
fnp-3459	69	10	the	the	DET
fnp-3459	69	11	lipoprotein	lipoprotein	ADJ
fnp-3459	69	12	particles	particle	NOUN
fnp-3459	69	13	impairing	impair	VERB
fnp-3459	69	14	delivery	delivery	NOUN
fnp-3459	69	15	of	of	ADP
fnp-3459	69	16	cholesterol	cholesterol	NOUN
fnp-3459	69	17	to	to	ADP
fnp-3459	69	18	neurons	neuron	NOUN
fnp-3459	69	19	and	and	CCONJ
fnp-3459	69	20	resulting	result	VERB
fnp-3459	69	21	in	in	ADP
fnp-3459	69	22	neuronal	neuronal	ADJ
fnp-3459	69	23	cholesterol	cholesterol	NOUN
fnp-3459	69	24	deficiency	deficiency	NOUN
fnp-3459	69	25	[	[	X
fnp-3459	69	26	36	36	NUM
fnp-3459	69	27	]	]	PUNCT
fnp-3459	69	28	.	.	PUNCT
fnp-3459	70	1	this	this	PRON
fnp-3459	70	2	has	have	VERB
fnp-3459	70	3	further	further	ADJ
fnp-3459	70	4	effects	effect	NOUN
fnp-3459	70	5	on	on	ADP
fnp-3459	70	6	aβ	aβ	NOUN
fnp-3459	70	7	as	as	SCONJ
fnp-3459	70	8	cholesterol	cholesterol	NOUN
fnp-3459	70	9	deficiency	deficiency	NOUN
fnp-3459	70	10	leads	lead	VERB
fnp-3459	70	11	to	to	ADP
fnp-3459	70	12	thinning	thinning	NOUN
fnp-3459	70	13	of	of	ADP
fnp-3459	70	14	the	the	DET
fnp-3459	70	15	cell	cell	NOUN
fnp-3459	70	16	membrane	membrane	NOUN
fnp-3459	70	17	,	,	PUNCT
fnp-3459	70	18	shifting	shift	VERB
fnp-3459	70	19	the	the	DET
fnp-3459	70	20	site	site	NOUN
fnp-3459	70	21	for	for	ADP
fnp-3459	70	22	secretase	secretase	NOUN
fnp-3459	70	23	cleavage	cleavage	NOUN
fnp-3459	70	24	of	of	ADP
fnp-3459	70	25	the	the	DET
fnp-3459	70	26	amyloid	amyloid	NOUN
fnp-3459	70	27	protein	protein	NOUN
fnp-3459	70	28	precursor	precursor	NOUN
fnp-3459	70	29	(	(	PUNCT
fnp-3459	70	30	app	app	PROPN
fnp-3459	70	31	)	)	PUNCT
fnp-3459	70	32	from	from	ADP
fnp-3459	70	33	producing	produce	VERB
fnp-3459	70	34	predominantly	predominantly	ADV
fnp-3459	70	35	the	the	DET
fnp-3459	70	36	shorter	short	ADJ
fnp-3459	70	37	form	form	NOUN
fnp-3459	70	38	of	of	ADP
fnp-3459	70	39	aβ	aβ	PRON
fnp-3459	70	40	(	(	PUNCT
fnp-3459	70	41	aβ40	aβ40	PROPN
fnp-3459	70	42	)	)	PUNCT
fnp-3459	70	43	to	to	ADP
fnp-3459	70	44	the	the	DET
fnp-3459	70	45	longer	long	ADJ
fnp-3459	70	46	form	form	NOUN
fnp-3459	70	47	(	(	PUNCT
fnp-3459	70	48	aβ42	aβ42	PROPN
fnp-3459	70	49	)	)	PUNCT
fnp-3459	70	50	which	which	PRON
fnp-3459	70	51	is	be	AUX
fnp-3459	70	52	relatively	relatively	ADV
fnp-3459	70	53	even	even	ADV
fnp-3459	70	54	more	more	ADV
fnp-3459	70	55	insoluble	insoluble	ADJ
fnp-3459	70	56	and	and	CCONJ
fnp-3459	70	57	prone	prone	ADJ
fnp-3459	70	58	to	to	ADP
fnp-3459	70	59	aggregation	aggregation	NOUN
fnp-3459	70	60	[	[	X
fnp-3459	70	61	37	37	NUM
fnp-3459	70	62	,	,	PUNCT
fnp-3459	70	63	38	38	NUM
fnp-3459	70	64	]	]	PUNCT
fnp-3459	70	65	.	.	PUNCT
fnp-3459	71	1	this	this	PRON
fnp-3459	71	2	exacerbates	exacerbate	VERB
fnp-3459	71	3	the	the	DET
fnp-3459	71	4	effect	effect	NOUN
fnp-3459	71	5	of	of	ADP
fnp-3459	71	6	trapped	trap	VERB
fnp-3459	71	7	lipoprotein	lipoprotein	ADJ
fnp-3459	71	8	particles	particle	NOUN
fnp-3459	71	9	as	as	SCONJ
fnp-3459	71	10	the	the	DET
fnp-3459	71	11	aβ42	aβ42	PROPN
fnp-3459	71	12	then	then	ADV
fnp-3459	71	13	coalesces	coalesce	VERB
fnp-3459	71	14	onto	onto	ADP
fnp-3459	71	15	the	the	DET
fnp-3459	71	16	initial	initial	ADJ
fnp-3459	71	17	plaque	plaque	NOUN
fnp-3459	71	18	seeds	seed	NOUN
fnp-3459	71	19	facilitating	facilitate	VERB
fnp-3459	71	20	their	their	PRON
fnp-3459	71	21	growth	growth	NOUN
fnp-3459	71	22	.	.	PUNCT
fnp-3459	72	1	in	in	ADP
fnp-3459	72	2	physiological	physiological	ADJ
fnp-3459	72	3	conditions	condition	NOUN
fnp-3459	72	4	,	,	PUNCT
fnp-3459	72	5	aβ	aβ	PRON
fnp-3459	72	6	is	be	AUX
fnp-3459	72	7	suggested	suggest	VERB
fnp-3459	72	8	to	to	PART
fnp-3459	72	9	act	act	VERB
fnp-3459	72	10	as	as	ADP
fnp-3459	72	11	a	a	DET
fnp-3459	72	12	regulator	regulator	NOUN
fnp-3459	72	13	of	of	ADP
fnp-3459	72	14	cholesterol	cholesterol	NOUN
fnp-3459	72	15	homeostasis	homeostasis	NOUN
fnp-3459	72	16	as	as	SCONJ
fnp-3459	72	17	observed	observe	VERB
fnp-3459	72	18	in	in	ADP
fnp-3459	72	19	experimental	experimental	ADJ
fnp-3459	72	20	models	model	NOUN
fnp-3459	72	21	[	[	X
fnp-3459	72	22	39	39	NUM
fnp-3459	72	23	]	]	PUNCT
fnp-3459	72	24	.	.	PUNCT
fnp-3459	73	1	in	in	ADP
fnp-3459	73	2	humans	human	NOUN
fnp-3459	73	3	,	,	PUNCT
fnp-3459	73	4	the	the	DET
fnp-3459	73	5	familial	familial	ADJ
fnp-3459	73	6	forms	form	NOUN
fnp-3459	73	7	of	of	ADP
fnp-3459	73	8	alzheimer	alzheimer	PROPN
fnp-3459	73	9	’s	’s	PART
fnp-3459	73	10	disease	disease	NOUN
fnp-3459	73	11	are	be	AUX
fnp-3459	73	12	due	due	ADJ
fnp-3459	73	13	to	to	ADP
fnp-3459	73	14	an	an	DET
fnp-3459	73	15	imbalance	imbalance	NOUN
fnp-3459	73	16	in	in	ADP
fnp-3459	73	17	aβ	aβ	ADP
fnp-3459	73	18	production	production	NOUN
fnp-3459	73	19	and	and	CCONJ
fnp-3459	73	20	are	be	AUX
fnp-3459	73	21	associated	associate	VERB
fnp-3459	73	22	with	with	ADP
fnp-3459	73	23	increased	increase	VERB
fnp-3459	73	24	cholesterol	cholesterol	NOUN
fnp-3459	73	25	levels	level	NOUN
fnp-3459	73	26	[	[	X
fnp-3459	73	27	40	40	NUM
fnp-3459	73	28	]	]	PUNCT
fnp-3459	73	29	.	.	PUNCT
fnp-3459	74	1	the	the	DET
fnp-3459	74	2	binding	binding	NOUN
fnp-3459	74	3	of	of	ADP
fnp-3459	74	4	apoe	apoe	NOUN
fnp-3459	74	5	to	to	ADP
fnp-3459	74	6	lipoprotein	lipoprotein	ADJ
fnp-3459	74	7	receptor	receptor	NOUN
fnp-3459	74	8	-	-	PUNCT
fnp-3459	74	9	related	relate	VERB
fnp-3459	74	10	protein	protein	NOUN
fnp-3459	74	11	(	(	PUNCT
fnp-3459	74	12	lrp	lrp	PROPN
fnp-3459	74	13	)	)	PUNCT
fnp-3459	75	1	[	[	X
fnp-3459	75	2	41	41	NUM
fnp-3459	75	3	]	]	PUNCT
fnp-3459	75	4	,	,	PUNCT
fnp-3459	75	5	the	the	DET
fnp-3459	75	6	major	major	ADJ
fnp-3459	75	7	apoe	apoe	ADJ
fnp-3459	75	8	receptor	receptor	NOUN
fnp-3459	75	9	on	on	ADP
fnp-3459	75	10	neurons	neuron	NOUN
fnp-3459	75	11	,	,	PUNCT
fnp-3459	75	12	is	be	AUX
fnp-3459	75	13	also	also	ADV
fnp-3459	75	14	involved	involve	VERB
fnp-3459	75	15	in	in	ADP
fnp-3459	75	16	the	the	DET
fnp-3459	75	17	cellular	cellular	ADJ
fnp-3459	75	18	uptake	uptake	NOUN
fnp-3459	75	19	of	of	ADP
fnp-3459	75	20	cholesterol	cholesterol	NOUN
fnp-3459	75	21	and	and	CCONJ
fnp-3459	75	22	aβ	aβ	NOUN
fnp-3459	75	23	,	,	PUNCT
fnp-3459	75	24	consistent	consistent	ADJ
fnp-3459	75	25	with	with	ADP
fnp-3459	75	26	apoe	apoe	NOUN
fnp-3459	75	27	,	,	PUNCT
fnp-3459	75	28	cholesterol	cholesterol	NOUN
fnp-3459	75	29	and	and	CCONJ
fnp-3459	75	30	aβ	aβ	NOUN
fnp-3459	75	31	all	all	PRON
fnp-3459	75	32	being	be	AUX
fnp-3459	75	33	components	component	NOUN
fnp-3459	75	34	of	of	ADP
fnp-3459	75	35	the	the	DET
fnp-3459	75	36	lipoprotein	lipoprotein	ADJ
fnp-3459	75	37	particle	particle	NOUN
fnp-3459	75	38	.	.	PUNCT
fnp-3459	76	1	in	in	ADP
fnp-3459	76	2	the	the	DET
fnp-3459	76	3	blood	blood	NOUN
fnp-3459	76	4	vessel	vessel	NOUN
fnp-3459	76	5	walls	wall	NOUN
fnp-3459	76	6	as	as	ADP
fnp-3459	76	7	cerebral	cerebral	ADJ
fnp-3459	76	8	amyloid	amyloid	NOUN
fnp-3459	76	9	angiopathy	angiopathy	ADJ
fnp-3459	76	10	(	(	PUNCT
fnp-3459	76	11	caa	caa	NOUN
fnp-3459	76	12	):	):	PUNCT
fnp-3459	76	13	aβ	aβ	PRON
fnp-3459	76	14	also	also	ADV
fnp-3459	76	15	colocalises	colocalise	VERB
fnp-3459	76	16	with	with	ADP
fnp-3459	76	17	apoe	apoe	NOUN
fnp-3459	76	18	in	in	ADP
fnp-3459	76	19	the	the	DET
fnp-3459	76	20	walls	wall	NOUN
fnp-3459	76	21	of	of	ADP
fnp-3459	76	22	cerebral	cerebral	ADJ
fnp-3459	76	23	blood	blood	NOUN
fnp-3459	76	24	vessels	vessel	NOUN
fnp-3459	76	25	suggesting	suggest	VERB
fnp-3459	76	26	that	that	SCONJ
fnp-3459	76	27	lipoprotein	lipoprotein	ADJ
fnp-3459	76	28	particles	particle	NOUN
fnp-3459	76	29	become	become	VERB
fnp-3459	76	30	trapped	trapped	ADJ
fnp-3459	76	31	in	in	ADP
fnp-3459	76	32	the	the	DET
fnp-3459	76	33	extracellular	extracellular	ADJ
fnp-3459	76	34	space	space	NOUN
fnp-3459	76	35	of	of	ADP
fnp-3459	76	36	the	the	DET
fnp-3459	76	37	vessel	vessel	NOUN
fnp-3459	76	38	wall	wall	PROPN
fnp-3459	76	39	basement	basement	PROPN
fnp-3459	76	40	membrane	membrane	NOUN
fnp-3459	76	41	as	as	ADP
fnp-3459	76	42	a	a	DET
fnp-3459	76	43	consequence	consequence	NOUN
fnp-3459	76	44	of	of	ADP
fnp-3459	76	45	age	age	NOUN
fnp-3459	76	46	-	-	PUNCT
fnp-3459	76	47	related	relate	VERB
fnp-3459	76	48	changes	change	NOUN
fnp-3459	76	49	.	.	PUNCT
fnp-3459	77	1	the	the	DET
fnp-3459	77	2	blood	blood	NOUN
fnp-3459	77	3	vessel	vessel	NOUN
fnp-3459	77	4	dysfunction	dysfunction	NOUN
fnp-3459	77	5	caused	cause	VERB
fnp-3459	77	6	by	by	ADP
fnp-3459	77	7	the	the	DET
fnp-3459	77	8	presence	presence	NOUN
fnp-3459	77	9	of	of	ADP
fnp-3459	77	10	caa	caa	PROPN
fnp-3459	77	11	further	far	ADV
fnp-3459	77	12	compromises	compromise	VERB
fnp-3459	77	13	brain	brain	NOUN
fnp-3459	77	14	function	function	NOUN
fnp-3459	77	15	by	by	ADP
fnp-3459	77	16	haemorrhage	haemorrhage	NOUN
fnp-3459	77	17	,	,	PUNCT
fnp-3459	77	18	ischaemia	ischaemia	NOUN
fnp-3459	77	19	and	and	CCONJ
fnp-3459	77	20	paralysing	paralyse	VERB
fnp-3459	77	21	autoregulation	autoregulation	NOUN
fnp-3459	77	22	of	of	ADP
fnp-3459	77	23	cerebral	cerebral	ADJ
fnp-3459	77	24	blood	blood	NOUN
fnp-3459	77	25	flow	flow	NOUN
fnp-3459	77	26	[	[	X
fnp-3459	77	27	42	42	NUM
fnp-3459	77	28	]	]	PUNCT
fnp-3459	77	29	.	.	PUNCT
fnp-3459	78	1	impaired	impair	VERB
fnp-3459	78	2	neuronal	neuronal	ADJ
fnp-3459	78	3	and	and	CCONJ
fnp-3459	78	4	synaptic	synaptic	ADJ
fnp-3459	78	5	function	function	NOUN
fnp-3459	78	6	deficiency	deficiency	NOUN
fnp-3459	78	7	of	of	ADP
fnp-3459	78	8	neuronal	neuronal	ADJ
fnp-3459	78	9	cholesterol	cholesterol	NOUN
fnp-3459	78	10	results	result	NOUN
fnp-3459	78	11	in	in	ADP
fnp-3459	78	12	impaired	impaired	ADJ
fnp-3459	78	13	communication	communication	NOUN
fnp-3459	78	14	between	between	ADP
fnp-3459	78	15	neurons	neuron	NOUN
fnp-3459	78	16	at	at	ADP
fnp-3459	78	17	the	the	DET
fnp-3459	78	18	synapse	synapse	NOUN
fnp-3459	78	19	,	,	PUNCT
fnp-3459	78	20	and	and	CCONJ
fnp-3459	78	21	particularly	particularly	ADV
fnp-3459	78	22	it	it	PRON
fnp-3459	78	23	interferes	interfere	VERB
fnp-3459	78	24	with	with	ADP
fnp-3459	78	25	the	the	DET
fnp-3459	78	26	alterations	alteration	NOUN
fnp-3459	78	27	in	in	ADP
fnp-3459	78	28	neurons	neuron	NOUN
fnp-3459	78	29	which	which	PRON
fnp-3459	78	30	underpin	underpin	VERB
fnp-3459	78	31	learning	learning	NOUN
fnp-3459	78	32	and	and	CCONJ
fnp-3459	78	33	memory	memory	NOUN
fnp-3459	78	34	(	(	PUNCT
fnp-3459	78	35	i.e.	i.e.	X
fnp-3459	78	36	synaptic	synaptic	ADJ
fnp-3459	78	37	plasticity	plasticity	NOUN
fnp-3459	78	38	)	)	PUNCT
fnp-3459	79	1	[	[	X
fnp-3459	79	2	43	43	NUM
fnp-3459	79	3	-	-	SYM
fnp-3459	79	4	46	46	NUM
fnp-3459	79	5	]	]	PUNCT
fnp-3459	79	6	.	.	PUNCT
fnp-3459	80	1	synaptic	synaptic	ADJ
fnp-3459	80	2	plasticity	plasticity	NOUN
fnp-3459	80	3	requires	require	VERB
fnp-3459	80	4	neuronal	neuronal	ADJ
fnp-3459	80	5	cell	cell	NOUN
fnp-3459	80	6	membrane	membrane	NOUN
fnp-3459	80	7	to	to	PART
fnp-3459	80	8	be	be	AUX
fnp-3459	80	9	synthesised	synthesise	VERB
fnp-3459	80	10	to	to	PART
fnp-3459	80	11	form	form	VERB
fnp-3459	80	12	and	and	CCONJ
fnp-3459	80	13	re	re	NOUN
fnp-3459	80	14	-	-	NOUN
fnp-3459	80	15	form	form	NOUN
fnp-3459	80	16	synapses	synapsis	NOUN
fnp-3459	80	17	as	as	SCONJ
fnp-3459	80	18	they	they	PRON
fnp-3459	80	19	are	be	AUX
fnp-3459	80	20	remodelled	remodelle	VERB
fnp-3459	80	21	.	.	PUNCT
fnp-3459	81	1	in	in	ADP
fnp-3459	81	2	neuronal	neuronal	ADJ
fnp-3459	81	3	cultures	culture	NOUN
fnp-3459	81	4	,	,	PUNCT
fnp-3459	81	5	the	the	DET
fnp-3459	81	6	presence	presence	NOUN
fnp-3459	81	7	of	of	ADP
fnp-3459	81	8	glial	glial	ADJ
fnp-3459	81	9	cells	cell	NOUN
fnp-3459	81	10	enhances	enhance	VERB
fnp-3459	81	11	the	the	DET
fnp-3459	81	12	formation	formation	NOUN
fnp-3459	81	13	and	and	CCONJ
fnp-3459	81	14	function	function	NOUN
fnp-3459	81	15	of	of	ADP
fnp-3459	81	16	synapses	synapsis	NOUN
fnp-3459	81	17	and	and	CCONJ
fnp-3459	81	18	the	the	DET
fnp-3459	81	19	essential	essential	ADJ
fnp-3459	81	20	factor	factor	NOUN
fnp-3459	81	21	mediating	mediate	VERB
fnp-3459	81	22	this	this	DET
fnp-3459	81	23	effect	effect	NOUN
fnp-3459	81	24	has	have	AUX
fnp-3459	81	25	been	be	AUX
fnp-3459	81	26	identified	identify	VERB
fnp-3459	81	27	as	as	ADP
fnp-3459	81	28	glia	glia	NOUN
fnp-3459	81	29	-	-	PUNCT
fnp-3459	81	30	derived	derive	VERB
fnp-3459	81	31	cholesterol	cholesterol	NOUN
fnp-3459	81	32	,	,	PUNCT
fnp-3459	81	33	delivered	deliver	VERB
fnp-3459	81	34	to	to	ADP
fnp-3459	81	35	the	the	DET
fnp-3459	81	36	neurons	neuron	NOUN
fnp-3459	81	37	by	by	ADP
fnp-3459	81	38	apoe	apoe	NOUN
fnp-3459	81	39	-	-	PUNCT
fnp-3459	81	40	containing	contain	VERB
fnp-3459	81	41	lipoprotein	lipoprotein	ADJ
fnp-3459	81	42	particles	particle	NOUN
fnp-3459	81	43	binding	bind	VERB
fnp-3459	81	44	to	to	ADP
fnp-3459	81	45	the	the	DET
fnp-3459	81	46	neuronal	neuronal	ADJ
fnp-3459	81	47	ldl	ldl	NOUN
fnp-3459	81	48	receptors	receptor	NOUN
fnp-3459	81	49	[	[	X
fnp-3459	81	50	11	11	NUM
fnp-3459	81	51	,	,	PUNCT
fnp-3459	81	52	47	47	NUM
fnp-3459	81	53	,	,	PUNCT
fnp-3459	81	54	48	48	NUM
fnp-3459	81	55	]	]	PUNCT
fnp-3459	81	56	.	.	PUNCT
fnp-3459	82	1	interestingly	interestingly	ADV
fnp-3459	82	2	,	,	PUNCT
fnp-3459	82	3	in	in	ADP
fnp-3459	82	4	a	a	DET
fnp-3459	82	5	number	number	NOUN
fnp-3459	82	6	of	of	ADP
fnp-3459	82	7	clinical	clinical	ADJ
fnp-3459	82	8	studies	study	NOUN
fnp-3459	82	9	of	of	ADP
fnp-3459	82	10	traumatic	traumatic	ADJ
fnp-3459	82	11	brain	brain	NOUN
fnp-3459	82	12	injury	injury	NOUN
fnp-3459	82	13	,	,	PUNCT
fnp-3459	82	14	the	the	DET
fnp-3459	82	15	possession	possession	NOUN
fnp-3459	82	16	of	of	ADP
fnp-3459	82	17	apoe	apoe	PROPN
fnp-3459	82	18	ε4	ε4	PROPN
fnp-3459	82	19	is	be	AUX
fnp-3459	82	20	associated	associate	VERB
fnp-3459	82	21	with	with	ADP
fnp-3459	82	22	a	a	DET
fnp-3459	82	23	worse	bad	ADJ
fnp-3459	82	24	outcome	outcome	NOUN
fnp-3459	82	25	and	and	CCONJ
fnp-3459	82	26	severe	severe	ADJ
fnp-3459	82	27	neurologic	neurologic	ADJ
fnp-3459	82	28	deficits	deficit	NOUN
fnp-3459	82	29	[	[	X
fnp-3459	82	30	49	49	NUM
fnp-3459	82	31	-	-	SYM
fnp-3459	82	32	51	51	NUM
fnp-3459	82	33	]	]	PUNCT
fnp-3459	82	34	.	.	PUNCT
fnp-3459	83	1	this	this	PRON
fnp-3459	83	2	seems	seem	VERB
fnp-3459	83	3	particularly	particularly	ADV
fnp-3459	83	4	so	so	ADV
fnp-3459	83	5	in	in	ADP
fnp-3459	83	6	young	young	ADJ
fnp-3459	83	7	people	people	NOUN
fnp-3459	83	8	in	in	ADP
fnp-3459	83	9	whom	whom	PRON
fnp-3459	83	10	neuronal	neuronal	ADJ
fnp-3459	83	11	plasticity	plasticity	NOUN
fnp-3459	83	12	after	after	ADP
fnp-3459	83	13	injury	injury	NOUN
fnp-3459	83	14	might	might	AUX
fnp-3459	83	15	otherwise	otherwise	ADV
fnp-3459	83	16	be	be	AUX
fnp-3459	83	17	more	more	ADV
fnp-3459	83	18	pronounced	pronounced	ADJ
fnp-3459	83	19	[	[	X
fnp-3459	83	20	50	50	NUM
fnp-3459	83	21	]	]	PUNCT
fnp-3459	83	22	.	.	PUNCT
fnp-3459	84	1	experimental	experimental	ADJ
fnp-3459	84	2	studies	study	NOUN
fnp-3459	84	3	in	in	ADP
fnp-3459	84	4	apoe	apoe	ADJ
fnp-3459	84	5	ε4	ε4	NOUN
fnp-3459	84	6	transgenic	transgenic	NOUN
fnp-3459	84	7	mice	mouse	NOUN
fnp-3459	84	8	confirmed	confirm	VERB
fnp-3459	84	9	impaired	impaired	ADJ
fnp-3459	84	10	neuronal	neuronal	ADJ
fnp-3459	84	11	plasticity	plasticity	NOUN
fnp-3459	84	12	after	after	ADP
fnp-3459	84	13	brain	brain	NOUN
fnp-3459	84	14	injury	injury	NOUN
fnp-3459	84	15	[	[	X
fnp-3459	84	16	52	52	NUM
fnp-3459	84	17	-	-	SYM
fnp-3459	84	18	56	56	NUM
fnp-3459	84	19	]	]	PUNCT
fnp-3459	84	20	.	.	PUNCT
fnp-3459	85	1	further	further	ADJ
fnp-3459	85	2	evidence	evidence	NOUN
fnp-3459	85	3	comes	come	VERB
fnp-3459	85	4	from	from	ADP
fnp-3459	85	5	experimental	experimental	ADJ
fnp-3459	85	6	models	model	NOUN
fnp-3459	85	7	of	of	ADP
fnp-3459	85	8	global	global	ADJ
fnp-3459	85	9	cerebral	cerebral	ADJ
fnp-3459	85	10	ischaemia	ischaemia	NOUN
fnp-3459	85	11	in	in	ADP
fnp-3459	85	12	which	which	PRON
fnp-3459	85	13	apoe	apoe	ADJ
fnp-3459	85	14	-	-	PUNCT
fnp-3459	85	15	deficient	deficient	ADJ
fnp-3459	85	16	mice	mouse	NOUN
fnp-3459	85	17	have	have	AUX
fnp-3459	85	18	increased	increase	VERB
fnp-3459	85	19	neuronal	neuronal	ADJ
fnp-3459	85	20	damage	damage	NOUN
fnp-3459	85	21	which	which	PRON
fnp-3459	85	22	is	be	AUX
fnp-3459	85	23	ameliorated	ameliorate	VERB
fnp-3459	85	24	by	by	ADP
fnp-3459	85	25	intraventricular	intraventricular	ADJ
fnp-3459	85	26	infusion	infusion	NOUN
fnp-3459	85	27	of	of	ADP
fnp-3459	85	28	lipoprotein	lipoprotein	ADJ
fnp-3459	85	29	particles	particle	NOUN
fnp-3459	85	30	[	[	X
fnp-3459	85	31	57	57	NUM
fnp-3459	85	32	]	]	PUNCT
fnp-3459	85	33	.	.	PUNCT
fnp-3459	86	1	in	in	ADP
fnp-3459	86	2	addition	addition	NOUN
fnp-3459	86	3	,	,	PUNCT
fnp-3459	86	4	agonists	agonist	NOUN
fnp-3459	86	5	of	of	ADP
fnp-3459	86	6	liver	liver	NOUN
fnp-3459	86	7	x	x	NOUN
fnp-3459	86	8	receptors	receptor	NOUN
fnp-3459	86	9	(	(	PUNCT
fnp-3459	86	10	lxr	lxr	PROPN
fnp-3459	86	11	)	)	PUNCT
fnp-3459	86	12	,	,	PUNCT
fnp-3459	86	13	which	which	PRON
fnp-3459	86	14	act	act	VERB
fnp-3459	86	15	as	as	ADP
fnp-3459	86	16	cholesterol	cholesterol	NOUN
fnp-3459	86	17	sensors	sensor	NOUN
fnp-3459	86	18	and	and	CCONJ
fnp-3459	86	19	promote	promote	VERB
fnp-3459	86	20	lipidation	lipidation	NOUN
fnp-3459	86	21	of	of	ADP
fnp-3459	86	22	apoe	apoe	NOUN
fnp-3459	86	23	by	by	ADP
fnp-3459	86	24	atp	atp	NOUN
fnp-3459	86	25	-	-	PUNCT
fnp-3459	86	26	binding	bind	VERB
fnp-3459	86	27	cassette	cassette	NOUN
fnp-3459	86	28	transporter	transporter	NOUN
fnp-3459	86	29	a1	a1	NOUN
fnp-3459	86	30	(	(	PUNCT
fnp-3459	86	31	abca1	abca1	NOUN
fnp-3459	86	32	)	)	PUNCT
fnp-3459	86	33	,	,	PUNCT
fnp-3459	86	34	ameliorate	ameliorate	VERB
fnp-3459	86	35	neuronal	neuronal	ADJ
fnp-3459	86	36	injury	injury	NOUN
fnp-3459	86	37	in	in	ADP
fnp-3459	86	38	experimental	experimental	ADJ
fnp-3459	86	39	models	model	NOUN
fnp-3459	86	40	of	of	ADP
fnp-3459	86	41	trauma	trauma	NOUN
fnp-3459	86	42	[	[	X
fnp-3459	86	43	58	58	NUM
fnp-3459	86	44	]	]	PUNCT
fnp-3459	86	45	and	and	CCONJ
fnp-3459	86	46	reverse	reverse	VERB
fnp-3459	86	47	deficits	deficit	NOUN
fnp-3459	86	48	in	in	ADP
fnp-3459	86	49	mouse	mouse	NOUN
fnp-3459	86	50	models	model	NOUN
fnp-3459	86	51	of	of	ADP
fnp-3459	86	52	ad	ad	NOUN
fnp-3459	86	53	[	[	X
fnp-3459	86	54	59	59	NUM
fnp-3459	86	55	]	]	PUNCT
fnp-3459	86	56	.	.	PUNCT
fnp-3459	87	1	the	the	DET
fnp-3459	87	2	effects	effect	NOUN
fnp-3459	87	3	of	of	ADP
fnp-3459	87	4	neuronal	neuronal	ADJ
fnp-3459	87	5	and	and	CCONJ
fnp-3459	87	6	synaptic	synaptic	ADJ
fnp-3459	87	7	dysfunction	dysfunction	NOUN
fnp-3459	87	8	due	due	ADP
fnp-3459	87	9	to	to	ADP
fnp-3459	87	10	lack	lack	NOUN
fnp-3459	87	11	of	of	ADP
fnp-3459	87	12	cholesterol	cholesterol	NOUN
fnp-3459	87	13	[	[	X
fnp-3459	87	14	60	60	NUM
fnp-3459	87	15	]	]	PUNCT
fnp-3459	87	16	would	would	AUX
fnp-3459	87	17	be	be	AUX
fnp-3459	87	18	expected	expect	VERB
fnp-3459	87	19	to	to	PART
fnp-3459	87	20	be	be	AUX
fnp-3459	87	21	most	most	ADV
fnp-3459	87	22	pronounced	pronounce	VERB
fnp-3459	87	23	in	in	ADP
fnp-3459	87	24	neuroanatomical	neuroanatomical	ADJ
fnp-3459	87	25	locations	location	NOUN
fnp-3459	87	26	in	in	ADP
fnp-3459	87	27	which	which	PRON
fnp-3459	87	28	plasticity	plasticity	NOUN
fnp-3459	87	29	is	be	AUX
fnp-3459	87	30	greatest	great	ADJ
fnp-3459	87	31	(	(	PUNCT
fnp-3459	87	32	i.e.	i.e.	X
fnp-3459	87	33	hippocampus	hippocampus	NOUN
fnp-3459	87	34	involved	involve	VERB
fnp-3459	87	35	in	in	ADP
fnp-3459	87	36	memory	memory	NOUN
fnp-3459	87	37	,	,	PUNCT
fnp-3459	87	38	association	association	NOUN
fnp-3459	87	39	cortex	cortex	NOUN
fnp-3459	87	40	involved	involve	VERB
fnp-3459	87	41	in	in	ADP
fnp-3459	87	42	interpretation	interpretation	NOUN
fnp-3459	87	43	of	of	ADP
fnp-3459	87	44	sensations	sensation	NOUN
fnp-3459	87	45	)	)	PUNCT
fnp-3459	87	46	and	and	CCONJ
fnp-3459	87	47	less	less	ADV
fnp-3459	87	48	severe	severe	ADJ
fnp-3459	87	49	or	or	CCONJ
fnp-3459	87	50	absent	absent	ADJ
fnp-3459	87	51	where	where	SCONJ
fnp-3459	87	52	plasticity	plasticity	NOUN
fnp-3459	87	53	is	be	AUX
fnp-3459	87	54	least	least	ADJ
fnp-3459	87	55	(	(	PUNCT
fnp-3459	87	56	i.e.	i.e.	X
fnp-3459	87	57	primary	primary	ADJ
fnp-3459	87	58	motor	motor	NOUN
fnp-3459	87	59	and	and	CCONJ
fnp-3459	87	60	sensory	sensory	ADJ
fnp-3459	87	61	cortex	cortex	NOUN
fnp-3459	87	62	,	,	PUNCT
fnp-3459	87	63	cerebellum	cerebellum	ADJ
fnp-3459	87	64	,	,	PUNCT
fnp-3459	87	65	spinal	spinal	ADJ
fnp-3459	87	66	cord	cord	NOUN
fnp-3459	87	67	)	)	PUNCT
fnp-3459	87	68	.	.	PUNCT
fnp-3459	88	1	this	this	PRON
fnp-3459	88	2	is	be	AUX
fnp-3459	88	3	consistent	consistent	ADJ
fnp-3459	88	4	with	with	ADP
fnp-3459	88	5	the	the	DET
fnp-3459	88	6	clinical	clinical	ADJ
fnp-3459	88	7	observations	observation	NOUN
fnp-3459	88	8	that	that	PRON
fnp-3459	88	9	the	the	DET
fnp-3459	88	10	hierarchical	hierarchical	ADJ
fnp-3459	88	11	sequence	sequence	NOUN
fnp-3459	88	12	of	of	ADP
fnp-3459	88	13	loss	loss	NOUN
fnp-3459	88	14	of	of	ADP
fnp-3459	88	15	functions	function	NOUN
fnp-3459	88	16	over	over	ADP
fnp-3459	88	17	time	time	NOUN
fnp-3459	88	18	in	in	ADP
fnp-3459	88	19	ad	ad	NOUN
fnp-3459	88	20	follows	follow	VERB
fnp-3459	88	21	the	the	DET
fnp-3459	88	22	distribution	distribution	NOUN
fnp-3459	88	23	of	of	ADP
fnp-3459	88	24	neuroplasticity	neuroplasticity	NOUN
fnp-3459	88	25	[	[	X
fnp-3459	88	26	61	61	NUM
fnp-3459	88	27	]	]	PUNCT
fnp-3459	88	28	.	.	PUNCT
fnp-3459	89	1	tau	tau	PROPN
fnp-3459	89	2	protein	protein	NOUN
fnp-3459	89	3	accumulation	accumulation	NOUN
fnp-3459	89	4	we	we	PRON
fnp-3459	89	5	propose	propose	VERB
fnp-3459	89	6	that	that	SCONJ
fnp-3459	89	7	neuronal	neuronal	ADJ
fnp-3459	89	8	cholesterol	cholesterol	NOUN
fnp-3459	89	9	deficiency	deficiency	NOUN
fnp-3459	89	10	,	,	PUNCT
fnp-3459	89	11	resulting	result	VERB
fnp-3459	89	12	from	from	ADP
fnp-3459	89	13	the	the	DET
fnp-3459	89	14	entrapment	entrapment	NOUN
fnp-3459	89	15	of	of	ADP
fnp-3459	89	16	lipoprotein	lipoprotein	ADJ
fnp-3459	89	17	particles	particle	NOUN
fnp-3459	89	18	,	,	PUNCT
fnp-3459	89	19	leads	lead	VERB
fnp-3459	89	20	to	to	ADP
fnp-3459	89	21	the	the	DET
fnp-3459	89	22	intracellular	intracellular	ADJ
fnp-3459	89	23	aggregation	aggregation	NOUN
fnp-3459	89	24	of	of	ADP
fnp-3459	89	25	tau	tau	PROPN
fnp-3459	89	26	.	.	PUNCT
fnp-3459	90	1	tau	tau	PROPN
fnp-3459	90	2	is	be	AUX
fnp-3459	90	3	involved	involve	VERB
fnp-3459	90	4	in	in	ADP
fnp-3459	90	5	maintaining	maintain	VERB
fnp-3459	90	6	the	the	DET
fnp-3459	90	7	cytoskeletal	cytoskeletal	ADJ
fnp-3459	90	8	structure	structure	NOUN
fnp-3459	90	9	of	of	ADP
fnp-3459	90	10	neurons	neuron	NOUN
fnp-3459	90	11	and	and	CCONJ
fnp-3459	90	12	,	,	PUNCT
fnp-3459	90	13	in	in	ADP
fnp-3459	90	14	particular	particular	ADJ
fnp-3459	90	15	,	,	PUNCT
fnp-3459	90	16	the	the	DET
fnp-3459	90	17	transport	transport	NOUN
fnp-3459	90	18	of	of	ADP
fnp-3459	90	19	proteins	protein	NOUN
fnp-3459	90	20	from	from	ADP
fnp-3459	90	21	the	the	DET
fnp-3459	90	22	cell	cell	NOUN
fnp-3459	90	23	body	body	NOUN
fnp-3459	90	24	along	along	ADP
fnp-3459	90	25	axons	axon	NOUN
fnp-3459	90	26	to	to	ADP
fnp-3459	90	27	the	the	DET
fnp-3459	90	28	synapses	synapsis	NOUN
fnp-3459	90	29	.	.	PUNCT
fnp-3459	91	1	accumulation	accumulation	NOUN
fnp-3459	91	2	of	of	ADP
fnp-3459	91	3	hyperphosphorylated	hyperphosphorylated	ADJ
fnp-3459	91	4	tau	tau	PROPN
fnp-3459	91	5	occurs	occur	VERB
fnp-3459	91	6	early	early	ADV
fnp-3459	91	7	in	in	ADP
fnp-3459	91	8	regions	region	NOUN
fnp-3459	91	9	where	where	SCONJ
fnp-3459	91	10	the	the	DET
fnp-3459	91	11	cholesterol	cholesterol	NOUN
fnp-3459	91	12	is	be	AUX
fnp-3459	91	13	most	most	ADV
fnp-3459	91	14	in	in	ADP
fnp-3459	91	15	demand	demand	NOUN
fnp-3459	91	16	,	,	PUNCT
fnp-3459	91	17	that	that	PRON
fnp-3459	91	18	is	be	AUX
fnp-3459	91	19	where	where	SCONJ
fnp-3459	91	20	the	the	DET
fnp-3459	91	21	rate	rate	NOUN
fnp-3459	91	22	of	of	ADP
fnp-3459	91	23	plasticity	plasticity	NOUN
fnp-3459	91	24	and	and	CCONJ
fnp-3459	91	25	synaptic	synaptic	ADJ
fnp-3459	91	26	remodelling	remodelling	NOUN
fnp-3459	91	27	is	be	AUX
fnp-3459	91	28	greatest	great	ADJ
fnp-3459	91	29	(	(	PUNCT
fnp-3459	91	30	i.e.	i.e.	X
fnp-3459	91	31	hippocampus	hippocampus	NOUN
fnp-3459	91	32	,	,	PUNCT
fnp-3459	91	33	association	association	NOUN
fnp-3459	91	34	cortex	cortex	NOUN
fnp-3459	91	35	)	)	PUNCT
fnp-3459	91	36	and	and	CCONJ
fnp-3459	91	37	later	later	ADV
fnp-3459	91	38	or	or	CCONJ
fnp-3459	91	39	not	not	PART
fnp-3459	91	40	at	at	ADV
fnp-3459	91	41	all	all	ADV
fnp-3459	91	42	where	where	SCONJ
fnp-3459	91	43	plasticity	plasticity	NOUN
fnp-3459	91	44	is	be	AUX
fnp-3459	91	45	least	least	ADJ
fnp-3459	91	46	(	(	PUNCT
fnp-3459	91	47	i.e.	i.e.	X
fnp-3459	91	48	primary	primary	ADJ
fnp-3459	91	49	motor	motor	NOUN
fnp-3459	91	50	and	and	CCONJ
fnp-3459	91	51	sensory	sensory	ADJ
fnp-3459	91	52	cortex	cortex	NOUN
fnp-3459	91	53	,	,	PUNCT
fnp-3459	91	54	cerebellum	cerebellum	ADJ
fnp-3459	91	55	,	,	PUNCT
fnp-3459	91	56	spinal	spinal	ADJ
fnp-3459	91	57	cord	cord	NOUN
fnp-3459	91	58	)	)	PUNCT
fnp-3459	91	59	.	.	PUNCT
fnp-3459	92	1	a	a	DET
fnp-3459	92	2	difficulty	difficulty	NOUN
fnp-3459	92	3	in	in	ADP
fnp-3459	92	4	trying	try	VERB
fnp-3459	92	5	to	to	PART
fnp-3459	92	6	explain	explain	VERB
fnp-3459	92	7	a	a	DET
fnp-3459	92	8	direct	direct	ADJ
fnp-3459	92	9	link	link	NOUN
fnp-3459	92	10	between	between	ADP
fnp-3459	92	11	aβ	aβ	PROPN
fnp-3459	92	12	and	and	CCONJ
fnp-3459	92	13	tau	tau	PROPN
fnp-3459	92	14	pathology	pathology	NOUN
fnp-3459	92	15	in	in	ADP
fnp-3459	92	16	ad	ad	NOUN
fnp-3459	92	17	has	have	AUX
fnp-3459	92	18	been	be	AUX
fnp-3459	92	19	that	that	SCONJ
fnp-3459	92	20	they	they	PRON
fnp-3459	92	21	appear	appear	VERB
fnp-3459	92	22	to	to	PART
fnp-3459	92	23	arise	arise	VERB
fnp-3459	92	24	in	in	ADP
fnp-3459	92	25	different	different	ADJ
fnp-3459	92	26	neuroanatomical	neuroanatomical	ADJ
fnp-3459	92	27	locations	location	NOUN
fnp-3459	92	28	;	;	PUNCT
fnp-3459	92	29	tau	tau	PROPN
fnp-3459	92	30	accumulation	accumulation	NOUN
fnp-3459	92	31	occurs	occur	VERB
fnp-3459	92	32	earlier	early	ADV
fnp-3459	92	33	in	in	ADP
fnp-3459	92	34	the	the	DET
fnp-3459	92	35	hippocampus	hippocampus	NOUN
fnp-3459	92	36	and	and	CCONJ
fnp-3459	92	37	associated	associated	ADJ
fnp-3459	92	38	structures	structure	NOUN
fnp-3459	92	39	,	,	PUNCT
fnp-3459	92	40	only	only	ADV
fnp-3459	92	41	spreading	spread	VERB
fnp-3459	92	42	later	later	ADV
fnp-3459	92	43	to	to	ADP
fnp-3459	92	44	the	the	DET
fnp-3459	92	45	cerebral	cerebral	ADJ
fnp-3459	92	46	neocortex	neocortex	NOUN
fnp-3459	92	47	,	,	PUNCT
fnp-3459	92	48	whereas	whereas	SCONJ
fnp-3459	92	49	aβ	aβ	DET
fnp-3459	92	50	accumulation	accumulation	NOUN
fnp-3459	92	51	occurs	occur	VERB
fnp-3459	92	52	early	early	ADV
fnp-3459	92	53	in	in	ADP
fnp-3459	92	54	the	the	DET
fnp-3459	92	55	cerebral	cerebral	ADJ
fnp-3459	92	56	neocortex	neocortex	NOUN
fnp-3459	92	57	.	.	PUNCT
fnp-3459	93	1	the	the	DET
fnp-3459	93	2	hypothesis	hypothesis	NOUN
fnp-3459	93	3	proposed	propose	VERB
fnp-3459	93	4	here	here	ADV
fnp-3459	93	5	that	that	SCONJ
fnp-3459	93	6	there	there	PRON
fnp-3459	93	7	is	be	VERB
fnp-3459	93	8	not	not	PART
fnp-3459	93	9	a	a	DET
fnp-3459	93	10	direct	direct	ADJ
fnp-3459	93	11	link	link	NOUN
fnp-3459	93	12	between	between	ADP
fnp-3459	93	13	aβ	aβ	NOUN
fnp-3459	93	14	and	and	CCONJ
fnp-3459	93	15	tau	tau	PROPN
fnp-3459	93	16	pathology	pathology	NOUN
fnp-3459	93	17	,	,	PUNCT
fnp-3459	93	18	but	but	CCONJ
fnp-3459	93	19	rather	rather	ADV
fnp-3459	93	20	that	that	SCONJ
fnp-3459	93	21	they	they	PRON
fnp-3459	93	22	are	be	AUX
fnp-3459	93	23	each	each	PRON
fnp-3459	93	24	driven	drive	VERB
fnp-3459	93	25	by	by	ADP
fnp-3459	93	26	cholesterol	cholesterol	NOUN
fnp-3459	93	27	deficiency	deficiency	NOUN
fnp-3459	93	28	,	,	PUNCT
fnp-3459	93	29	resolves	resolve	VERB
fnp-3459	93	30	this	this	DET
fnp-3459	93	31	conundrum	conundrum	NOUN
fnp-3459	93	32	.	.	PUNCT
fnp-3459	94	1	direct	direct	ADJ
fnp-3459	94	2	experimental	experimental	ADJ
fnp-3459	94	3	support	support	NOUN
fnp-3459	94	4	comes	come	VERB
fnp-3459	94	5	from	from	ADP
fnp-3459	94	6	cholesterol	cholesterol	NOUN
fnp-3459	94	7	depletion	depletion	NOUN
fnp-3459	94	8	in	in	ADP
fnp-3459	94	9	neuronal	neuronal	ADJ
fnp-3459	94	10	cultures	culture	NOUN
fnp-3459	94	11	which	which	PRON
fnp-3459	94	12	induces	induce	VERB
fnp-3459	94	13	tau	tau	PROPN
fnp-3459	94	14	hyperphosphorylation	hyperphosphorylation	NOUN
fnp-3459	94	15	that	that	PRON
fnp-3459	94	16	can	can	AUX
fnp-3459	94	17	be	be	AUX
fnp-3459	94	18	prevented	prevent	VERB
fnp-3459	94	19	by	by	ADP
fnp-3459	94	20	treatment	treatment	NOUN
fnp-3459	94	21	with	with	ADP
fnp-3459	94	22	lipoproteins	lipoprotein	NOUN
fnp-3459	94	23	and	and	CCONJ
fnp-3459	94	24	cholesterol	cholesterol	NOUN
fnp-3459	94	25	[	[	X
fnp-3459	94	26	62	62	NUM
fnp-3459	94	27	]	]	PUNCT
fnp-3459	94	28	.	.	PUNCT
fnp-3459	95	1	the	the	DET
fnp-3459	95	2	link	link	NOUN
fnp-3459	95	3	between	between	ADP
fnp-3459	95	4	neuronal	neuronal	ADJ
fnp-3459	95	5	cholesterol	cholesterol	NOUN
fnp-3459	95	6	deficiency	deficiency	NOUN
fnp-3459	95	7	and	and	CCONJ
fnp-3459	95	8	tau	tau	PROPN
fnp-3459	95	9	accumulation	accumulation	NOUN
fnp-3459	95	10	is	be	AUX
fnp-3459	95	11	further	far	ADV
fnp-3459	95	12	highlighted	highlight	VERB
fnp-3459	95	13	by	by	ADP
fnp-3459	95	14	the	the	DET
fnp-3459	95	15	occurrence	occurrence	NOUN
fnp-3459	95	16	of	of	ADP
fnp-3459	95	17	tangles	tangle	NOUN
fnp-3459	95	18	at	at	ADP
fnp-3459	95	19	a	a	DET
fnp-3459	95	20	young	young	ADJ
fnp-3459	95	21	age	age	NOUN
fnp-3459	95	22	in	in	ADP
fnp-3459	95	23	niemann	niemann	PROPN
fnp-3459	95	24	-	-	PUNCT
fnp-3459	95	25	pick	pick	NOUN
fnp-3459	95	26	type	type	NOUN
fnp-3459	95	27	disease	disease	NOUN
fnp-3459	95	28	type	type	NOUN
fnp-3459	95	29	c	c	NOUN
fnp-3459	95	30	,	,	PUNCT
fnp-3459	95	31	a	a	DET
fnp-3459	95	32	rare	rare	ADJ
fnp-3459	95	33	progressive	progressive	ADJ
fnp-3459	95	34	genetic	genetic	ADJ
fnp-3459	95	35	disorder	disorder	NOUN
fnp-3459	95	36	characterised	characterise	VERB
fnp-3459	95	37	by	by	ADP
fnp-3459	95	38	the	the	DET
fnp-3459	95	39	inability	inability	NOUN
fnp-3459	95	40	of	of	ADP
fnp-3459	95	41	the	the	DET
fnp-3459	95	42	body	body	NOUN
fnp-3459	95	43	to	to	PART
fnp-3459	95	44	transport	transport	VERB
fnp-3459	95	45	cholesterol	cholesterol	NOUN
fnp-3459	95	46	and	and	CCONJ
fnp-3459	95	47	lipids	lipid	VERB
fnp-3459	95	48	[	[	X
fnp-3459	95	49	63	63	NUM
fnp-3459	95	50	-	-	SYM
fnp-3459	95	51	64	64	NUM
fnp-3459	95	52	]	]	PUNCT
fnp-3459	95	53	.	.	PUNCT
fnp-3459	96	1	additional	additional	ADJ
fnp-3459	96	2	circumstantial	circumstantial	ADJ
fnp-3459	96	3	evidence	evidence	NOUN
fnp-3459	96	4	supporting	support	VERB
fnp-3459	96	5	a	a	DET
fnp-3459	96	6	link	link	NOUN
fnp-3459	96	7	between	between	ADP
fnp-3459	96	8	cholesterol	cholesterol	NOUN
fnp-3459	96	9	deficiency	deficiency	NOUN
fnp-3459	96	10	and	and	CCONJ
fnp-3459	96	11	tangle	tangle	VERB
fnp-3459	96	12	formation	formation	NOUN
fnp-3459	96	13	potentially	potentially	ADV
fnp-3459	96	14	comes	come	VERB
fnp-3459	96	15	from	from	ADP
fnp-3459	96	16	the	the	DET
fnp-3459	96	17	study	study	NOUN
fnp-3459	96	18	of	of	ADP
fnp-3459	96	19	chronic	chronic	ADJ
fnp-3459	96	20	traumatic	traumatic	ADJ
fnp-3459	96	21	encephalopathy	encephalopathy	NOUN
fnp-3459	96	22	(	(	PUNCT
fnp-3459	96	23	cte	cte	NOUN
fnp-3459	96	24	)	)	PUNCT
fnp-3459	96	25	.	.	PUNCT
fnp-3459	97	1	cte	cte	PROPN
fnp-3459	97	2	is	be	AUX
fnp-3459	97	3	a	a	DET
fnp-3459	97	4	condition	condition	NOUN
fnp-3459	97	5	caused	cause	VERB
fnp-3459	97	6	by	by	ADP
fnp-3459	97	7	repeated	repeat	VERB
fnp-3459	97	8	blows	blow	NOUN
fnp-3459	97	9	to	to	ADP
fnp-3459	97	10	the	the	DET
fnp-3459	97	11	head	head	NOUN
fnp-3459	97	12	,	,	PUNCT
fnp-3459	97	13	typically	typically	ADV
fnp-3459	97	14	in	in	ADP
fnp-3459	97	15	boxing	boxing	NOUN
fnp-3459	97	16	and	and	CCONJ
fnp-3459	97	17	other	other	ADJ
fnp-3459	97	18	sports	sport	NOUN
fnp-3459	97	19	,	,	PUNCT
fnp-3459	97	20	and	and	CCONJ
fnp-3459	97	21	is	be	AUX
fnp-3459	97	22	associated	associate	VERB
fnp-3459	97	23	with	with	ADP
fnp-3459	97	24	the	the	DET
fnp-3459	97	25	development	development	NOUN
fnp-3459	97	26	of	of	ADP
fnp-3459	97	27	dementia	dementia	NOUN
fnp-3459	97	28	with	with	ADP
fnp-3459	97	29	the	the	DET
fnp-3459	97	30	formation	formation	NOUN
fnp-3459	97	31	of	of	ADP
fnp-3459	97	32	tangles	tangle	NOUN
fnp-3459	97	33	as	as	ADP
fnp-3459	97	34	the	the	DET
fnp-3459	97	35	key	key	ADJ
fnp-3459	97	36	pathological	pathological	ADJ
fnp-3459	97	37	feature	feature	NOUN
fnp-3459	97	38	[	[	X
fnp-3459	97	39	65	65	NUM
fnp-3459	97	40	]	]	PUNCT
fnp-3459	97	41	.	.	PUNCT
fnp-3459	98	1	it	it	PRON
fnp-3459	98	2	has	have	AUX
fnp-3459	98	3	been	be	AUX
fnp-3459	98	4	found	find	VERB
fnp-3459	98	5	that	that	SCONJ
fnp-3459	98	6	after	after	ADP
fnp-3459	98	7	a	a	DET
fnp-3459	98	8	head	head	NOUN
fnp-3459	98	9	injury	injury	NOUN
fnp-3459	98	10	,	,	PUNCT
fnp-3459	98	11	levels	level	NOUN
fnp-3459	98	12	of	of	ADP
fnp-3459	98	13	apoe	apoe	NOUN
fnp-3459	98	14	and	and	CCONJ
fnp-3459	98	15	cholesterol	cholesterol	NOUN
fnp-3459	98	16	-	-	PUNCT
fnp-3459	98	17	containing	contain	VERB
fnp-3459	98	18	lipoproteins	lipoprotein	NOUN
fnp-3459	98	19	in	in	ADP
fnp-3459	98	20	the	the	DET
fnp-3459	98	21	cerebrospinal	cerebrospinal	ADJ
fnp-3459	98	22	fluid	fluid	NOUN
fnp-3459	98	23	plummet	plummet	NOUN
fnp-3459	98	24	,	,	PUNCT
fnp-3459	98	25	just	just	ADV
fnp-3459	98	26	at	at	ADP
fnp-3459	98	27	the	the	DET
fnp-3459	98	28	time	time	NOUN
fnp-3459	98	29	when	when	SCONJ
fnp-3459	98	30	there	there	PRON
fnp-3459	98	31	is	be	VERB
fnp-3459	98	32	an	an	DET
fnp-3459	98	33	increased	increase	VERB
fnp-3459	98	34	demand	demand	NOUN
fnp-3459	98	35	for	for	ADP
fnp-3459	98	36	cholesterol	cholesterol	NOUN
fnp-3459	98	37	for	for	ADP
fnp-3459	98	38	neuronal	neuronal	ADJ
fnp-3459	98	39	repair	repair	NOUN
fnp-3459	98	40	[	[	X
fnp-3459	98	41	66	66	NUM
fnp-3459	98	42	-	-	SYM
fnp-3459	98	43	68	68	NUM
fnp-3459	98	44	]	]	PUNCT
fnp-3459	98	45	.	.	PUNCT
fnp-3459	99	1	this	this	DET
fnp-3459	99	2	relative	relative	ADJ
fnp-3459	99	3	deficiency	deficiency	NOUN
fnp-3459	99	4	of	of	ADP
fnp-3459	99	5	cholesterol	cholesterol	NOUN
fnp-3459	99	6	,	,	PUNCT
fnp-3459	99	7	when	when	SCONJ
fnp-3459	99	8	recurrent	recurrent	ADJ
fnp-3459	99	9	over	over	ADP
fnp-3459	99	10	time	time	NOUN
fnp-3459	99	11	with	with	ADP
fnp-3459	99	12	repeated	repeat	VERB
fnp-3459	99	13	blows	blow	NOUN
fnp-3459	99	14	to	to	ADP
fnp-3459	99	15	the	the	DET
fnp-3459	99	16	head	head	NOUN
fnp-3459	99	17	,	,	PUNCT
fnp-3459	99	18	could	could	AUX
fnp-3459	99	19	explain	explain	VERB
fnp-3459	99	20	the	the	DET
fnp-3459	99	21	development	development	NOUN
fnp-3459	99	22	of	of	ADP
fnp-3459	99	23	tangles	tangle	NOUN
fnp-3459	99	24	in	in	ADP
fnp-3459	99	25	cte	cte	NOUN
fnp-3459	99	26	[	[	X
fnp-3459	99	27	51	51	NUM
fnp-3459	99	28	-	-	SYM
fnp-3459	99	29	56	56	NUM
fnp-3459	99	30	]	]	PUNCT
fnp-3459	100	1	[	[	X
fnp-3459	100	2	65	65	NUM
fnp-3459	100	3	]	]	X
fnp-3459	100	4	studies	study	NOUN
fnp-3459	100	5	using	use	VERB
fnp-3459	100	6	cerebral	cerebral	ADJ
fnp-3459	100	7	organoids	organoid	NOUN
fnp-3459	100	8	derived	derive	VERB
fnp-3459	100	9	from	from	ADP
fnp-3459	100	10	ad	ad	NOUN
fnp-3459	100	11	patients	patient	NOUN
fnp-3459	100	12	highlight	highlight	VERB
fnp-3459	100	13	an	an	DET
fnp-3459	100	14	association	association	NOUN
fnp-3459	100	15	of	of	ADP
fnp-3459	100	16	tau	tau	PROPN
fnp-3459	100	17	pathology	pathology	NOUN
fnp-3459	100	18	with	with	ADP
fnp-3459	100	19	apoe	apoe	PROPN
fnp-3459	100	20	ε4	ε4	NOUN
fnp-3459	100	21	carriage	carriage	NOUN
fnp-3459	100	22	[	[	X
fnp-3459	100	23	69	69	NUM
fnp-3459	100	24	]	]	PUNCT
fnp-3459	100	25	.	.	PUNCT
fnp-3459	101	1	glial	glial	ADJ
fnp-3459	101	2	cell	cell	NOUN
fnp-3459	101	3	dysfunction	dysfunction	NOUN
fnp-3459	101	4	astrocytes	astrocyte	NOUN
fnp-3459	101	5	and	and	CCONJ
fnp-3459	101	6	microglia	microglia	NOUN
fnp-3459	101	7	have	have	VERB
fnp-3459	101	8	a	a	DET
fnp-3459	101	9	major	major	ADJ
fnp-3459	101	10	role	role	NOUN
fnp-3459	101	11	in	in	ADP
fnp-3459	101	12	supporting	support	VERB
fnp-3459	101	13	neurons	neuron	NOUN
fnp-3459	101	14	and	and	CCONJ
fnp-3459	101	15	activation	activation	NOUN
fnp-3459	101	16	of	of	ADP
fnp-3459	101	17	glial	glial	ADJ
fnp-3459	101	18	cells	cell	NOUN
fnp-3459	101	19	is	be	AUX
fnp-3459	101	20	a	a	DET
fnp-3459	101	21	hallmark	hallmark	NOUN
fnp-3459	101	22	of	of	ADP
fnp-3459	101	23	ad	ad	NOUN
fnp-3459	101	24	.	.	PUNCT
fnp-3459	102	1	in	in	ADP
fnp-3459	102	2	particular	particular	ADJ
fnp-3459	102	3	,	,	PUNCT
fnp-3459	102	4	they	they	PRON
fnp-3459	102	5	play	play	VERB
fnp-3459	102	6	an	an	DET
fnp-3459	102	7	important	important	ADJ
fnp-3459	102	8	role	role	NOUN
fnp-3459	102	9	in	in	ADP
fnp-3459	102	10	the	the	DET
fnp-3459	102	11	cycling	cycling	NOUN
fnp-3459	102	12	of	of	ADP
fnp-3459	102	13	lipoprotein	lipoprotein	ADJ
fnp-3459	102	14	particles	particle	NOUN
fnp-3459	102	15	,	,	PUNCT
fnp-3459	102	16	scavenging	scavenge	VERB
fnp-3459	102	17	lipid	lipid	NOUN
fnp-3459	102	18	debris	debris	NOUN
fnp-3459	102	19	from	from	ADP
fnp-3459	102	20	degenerating	degenerate	VERB
fnp-3459	102	21	neuron	neuron	NOUN
fnp-3459	102	22	/	/	SYM
fnp-3459	102	23	synapses	synapsis	NOUN
fnp-3459	102	24	,	,	PUNCT
fnp-3459	102	25	lipidation	lipidation	VERB
fnp-3459	102	26	the	the	DET
fnp-3459	102	27	particles	particle	NOUN
fnp-3459	102	28	and	and	CCONJ
fnp-3459	102	29	releasing	release	VERB
fnp-3459	102	30	them	they	PRON
fnp-3459	102	31	for	for	ADP
fnp-3459	102	32	transport	transport	NOUN
fnp-3459	102	33	and	and	CCONJ
fnp-3459	102	34	uptake	uptake	ADJ
fnp-3459	102	35	by	by	ADP
fnp-3459	102	36	neurons	neuron	NOUN
fnp-3459	102	37	[	[	X
fnp-3459	102	38	70	70	NUM
fnp-3459	102	39	]	]	PUNCT
fnp-3459	102	40	.	.	PUNCT
fnp-3459	103	1	in	in	ADP
fnp-3459	103	2	apoe	apoe	ADJ
fnp-3459	103	3	ε4	ε4	NOUN
fnp-3459	103	4	carriers	carrier	NOUN
fnp-3459	103	5	,	,	PUNCT
fnp-3459	103	6	the	the	DET
fnp-3459	103	7	brain	brain	NOUN
fnp-3459	103	8	is	be	AUX
fnp-3459	103	9	relatively	relatively	ADV
fnp-3459	103	10	deficient	deficient	ADJ
fnp-3459	103	11	in	in	ADP
fnp-3459	103	12	apoe	apoe	NOUN
fnp-3459	103	13	and	and	CCONJ
fnp-3459	103	14	the	the	DET
fnp-3459	103	15	lipoprotein	lipoprotein	ADJ
fnp-3459	103	16	particles	particle	NOUN
fnp-3459	103	17	are	be	AUX
fnp-3459	103	18	smaller	small	ADJ
fnp-3459	104	1	[	[	X
fnp-3459	104	2	71	71	NUM
fnp-3459	104	3	]	]	X
fnp-3459	104	4	,	,	PUNCT
fnp-3459	104	5	more	more	ADV
fnp-3459	104	6	prone	prone	ADJ
fnp-3459	104	7	to	to	PART
fnp-3459	104	8	aggregate	aggregate	VERB
fnp-3459	104	9	and	and	CCONJ
fnp-3459	104	10	carry	carry	VERB
fnp-3459	104	11	less	less	ADJ
fnp-3459	104	12	cholesterol	cholesterol	NOUN
fnp-3459	104	13	,	,	PUNCT
fnp-3459	104	14	rendering	render	VERB
fnp-3459	104	15	them	they	PRON
fnp-3459	104	16	particularly	particularly	ADV
fnp-3459	104	17	vulnerable	vulnerable	ADJ
fnp-3459	104	18	to	to	ADP
fnp-3459	104	19	the	the	DET
fnp-3459	104	20	effects	effect	NOUN
fnp-3459	104	21	of	of	ADP
fnp-3459	104	22	age	age	NOUN
fnp-3459	104	23	-	-	PUNCT
fnp-3459	104	24	related	relate	VERB
fnp-3459	104	25	cholesterol	cholesterol	NOUN
fnp-3459	104	26	deficiency	deficiency	NOUN
fnp-3459	104	27	.	.	PUNCT
fnp-3459	105	1	human	human	ADJ
fnp-3459	105	2	induced	induce	VERB
fnp-3459	105	3	pluripotent	pluripotent	NOUN
fnp-3459	105	4	cell	cell	NOUN
fnp-3459	105	5	(	(	PUNCT
fnp-3459	105	6	ipsc)-derived	ipsc)-derive	VERB
fnp-3459	105	7	astrocytes	astrocyte	NOUN
fnp-3459	105	8	from	from	ADP
fnp-3459	105	9	ε4	ε4	PROPN
fnp-3459	105	10	homozygotes	homozygote	NOUN
fnp-3459	105	11	produce	produce	VERB
fnp-3459	105	12	lipoprotein	lipoprotein	ADJ
fnp-3459	105	13	particles	particle	NOUN
fnp-3459	105	14	that	that	PRON
fnp-3459	105	15	are	be	AUX
fnp-3459	105	16	smaller	small	ADJ
fnp-3459	105	17	,	,	PUNCT
fnp-3459	105	18	carry	carry	VERB
fnp-3459	105	19	less	less	ADJ
fnp-3459	105	20	cholesterol	cholesterol	NOUN
fnp-3459	105	21	and	and	CCONJ
fnp-3459	105	22	support	support	NOUN
fnp-3459	105	23	neurons	neuron	NOUN
fnp-3459	105	24	less	less	ADV
fnp-3459	105	25	well	well	ADV
fnp-3459	105	26	in	in	ADP
fnp-3459	105	27	terms	term	NOUN
fnp-3459	105	28	of	of	ADP
fnp-3459	105	29	viability	viability	NOUN
fnp-3459	105	30	and	and	CCONJ
fnp-3459	105	31	expression	expression	NOUN
fnp-3459	105	32	of	of	ADP
fnp-3459	105	33	synaptic	synaptic	ADJ
fnp-3459	105	34	proteins	protein	NOUN
fnp-3459	105	35	compared	compare	VERB
fnp-3459	105	36	with	with	ADP
fnp-3459	105	37	those	those	PRON
fnp-3459	105	38	from	from	ADP
fnp-3459	105	39	ε3	ε3	ADJ
fnp-3459	105	40	carriers	carrier	NOUN
fnp-3459	105	41	[	[	X
fnp-3459	105	42	72	72	NUM
fnp-3459	105	43	]	]	PUNCT
fnp-3459	105	44	.	.	PUNCT
fnp-3459	106	1	microglia	microglia	PROPN
fnp-3459	106	2	are	be	AUX
fnp-3459	106	3	the	the	DET
fnp-3459	106	4	immune	immune	ADJ
fnp-3459	106	5	cells	cell	NOUN
fnp-3459	106	6	of	of	ADP
fnp-3459	106	7	the	the	DET
fnp-3459	106	8	brain	brain	NOUN
fnp-3459	106	9	and	and	CCONJ
fnp-3459	106	10	are	be	AUX
fnp-3459	106	11	markedly	markedly	ADV
fnp-3459	106	12	activated	activate	VERB
fnp-3459	106	13	in	in	ADP
fnp-3459	106	14	ad	ad	NOUN
fnp-3459	106	15	[	[	X
fnp-3459	106	16	73	73	NUM
fnp-3459	106	17	,	,	PUNCT
fnp-3459	106	18	74	74	NUM
fnp-3459	106	19	]	]	PUNCT
fnp-3459	106	20	.	.	PUNCT
fnp-3459	107	1	many	many	ADJ
fnp-3459	107	2	of	of	ADP
fnp-3459	107	3	the	the	DET
fnp-3459	107	4	genes	gene	NOUN
fnp-3459	107	5	identified	identify	VERB
fnp-3459	107	6	in	in	ADP
fnp-3459	107	7	genome	genome	NOUN
fnp-3459	107	8	-	-	PUNCT
fnp-3459	107	9	wide	wide	ADJ
fnp-3459	107	10	association	association	NOUN
fnp-3459	107	11	studies	study	NOUN
fnp-3459	107	12	are	be	AUX
fnp-3459	107	13	expressed	express	VERB
fnp-3459	107	14	by	by	ADP
fnp-3459	107	15	microglia	microglia	NOUN
fnp-3459	107	16	,	,	PUNCT
fnp-3459	107	17	indicating	indicate	VERB
fnp-3459	107	18	that	that	SCONJ
fnp-3459	107	19	they	they	PRON
fnp-3459	107	20	play	play	VERB
fnp-3459	107	21	an	an	DET
fnp-3459	107	22	important	important	ADJ
fnp-3459	107	23	role	role	NOUN
fnp-3459	107	24	in	in	ADP
fnp-3459	107	25	the	the	DET
fnp-3459	107	26	development	development	NOUN
fnp-3459	107	27	and/or	and/or	CCONJ
fnp-3459	107	28	progression	progression	NOUN
fnp-3459	107	29	of	of	ADP
fnp-3459	107	30	the	the	DET
fnp-3459	107	31	disease	disease	NOUN
fnp-3459	107	32	[	[	X
fnp-3459	107	33	75	75	NUM
fnp-3459	107	34	]	]	PUNCT
fnp-3459	107	35	.	.	PUNCT
fnp-3459	108	1	the	the	DET
fnp-3459	108	2	presence	presence	NOUN
fnp-3459	108	3	of	of	ADP
fnp-3459	108	4	extracellular	extracellular	ADJ
fnp-3459	108	5	aβ	aβ	NOUN
fnp-3459	108	6	expelled	expel	VERB
fnp-3459	108	7	by	by	ADP
fnp-3459	108	8	trapped	trap	VERB
fnp-3459	108	9	and	and	CCONJ
fnp-3459	108	10	degraded	degraded	ADJ
fnp-3459	108	11	lipoprotein	lipoprotein	ADJ
fnp-3459	108	12	particles	particle	NOUN
fnp-3459	108	13	is	be	AUX
fnp-3459	108	14	putatively	putatively	ADV
fnp-3459	108	15	recognised	recognise	VERB
fnp-3459	108	16	by	by	ADP
fnp-3459	108	17	the	the	DET
fnp-3459	108	18	microglial	microglial	ADJ
fnp-3459	108	19	pattern	pattern	NOUN
fnp-3459	108	20	recognition	recognition	NOUN
fnp-3459	108	21	receptors	receptor	NOUN
fnp-3459	108	22	(	(	PUNCT
fnp-3459	108	23	pprs	pprs	ADJ
fnp-3459	108	24	)	)	PUNCT
fnp-3459	108	25	evolved	evolve	VERB
fnp-3459	108	26	to	to	PART
fnp-3459	108	27	detect	detect	VERB
fnp-3459	108	28	molecular	molecular	ADJ
fnp-3459	108	29	patterns	pattern	NOUN
fnp-3459	108	30	associated	associate	VERB
fnp-3459	108	31	with	with	ADP
fnp-3459	108	32	the	the	DET
fnp-3459	108	33	bacterial	bacterial	ADJ
fnp-3459	108	34	cell	cell	NOUN
fnp-3459	108	35	walls	wall	NOUN
fnp-3459	108	36	.	.	PUNCT
fnp-3459	109	1	the	the	DET
fnp-3459	109	2	consequent	consequent	ADJ
fnp-3459	109	3	pro	pro	ADJ
fnp-3459	109	4	-	-	ADJ
fnp-3459	109	5	inflammatory	inflammatory	ADJ
fnp-3459	109	6	state	state	NOUN
fnp-3459	109	7	provoked	provoke	VERB
fnp-3459	109	8	by	by	ADP
fnp-3459	109	9	this	this	DET
fnp-3459	109	10	response	response	NOUN
fnp-3459	109	11	causes	cause	VERB
fnp-3459	109	12	release	release	NOUN
fnp-3459	109	13	of	of	ADP
fnp-3459	109	14	cytotoxic	cytotoxic	ADJ
fnp-3459	109	15	substance	substance	NOUN
fnp-3459	109	16	evolved	evolve	VERB
fnp-3459	109	17	to	to	PART
fnp-3459	109	18	destroy	destroy	VERB
fnp-3459	109	19	invading	invade	VERB
fnp-3459	109	20	micro	micro	NOUN
fnp-3459	109	21	-	-	NOUN
fnp-3459	109	22	organisms	organism	NOUN
fnp-3459	109	23	,	,	PUNCT
fnp-3459	109	24	which	which	PRON
fnp-3459	109	25	inadvertently	inadvertently	ADV
fnp-3459	109	26	has	have	VERB
fnp-3459	109	27	a	a	DET
fnp-3459	109	28	harmful	harmful	ADJ
fnp-3459	109	29	effect	effect	NOUN
fnp-3459	109	30	on	on	ADP
fnp-3459	109	31	neurons	neuron	NOUN
fnp-3459	109	32	,	,	PUNCT
fnp-3459	109	33	compounding	compound	VERB
fnp-3459	109	34	the	the	DET
fnp-3459	109	35	effects	effect	NOUN
fnp-3459	109	36	of	of	ADP
fnp-3459	109	37	cholesterol	cholesterol	NOUN
fnp-3459	109	38	deficiency	deficiency	NOUN
fnp-3459	109	39	[	[	X
fnp-3459	109	40	73	73	NUM
fnp-3459	109	41	,	,	PUNCT
fnp-3459	109	42	76	76	NUM
fnp-3459	109	43	]	]	PUNCT
fnp-3459	109	44	.	.	PUNCT
fnp-3459	110	1	weaknesses	weakness	NOUN
fnp-3459	110	2	/	/	SYM
fnp-3459	110	3	limitations	limitation	NOUN
fnp-3459	110	4	of	of	ADP
fnp-3459	110	5	the	the	DET
fnp-3459	110	6	hypothesis	hypothesis	NOUN
fnp-3459	110	7	the	the	DET
fnp-3459	110	8	ideas	idea	NOUN
fnp-3459	110	9	presented	present	VERB
fnp-3459	110	10	here	here	ADV
fnp-3459	110	11	form	form	VERB
fnp-3459	110	12	a	a	DET
fnp-3459	110	13	hypothesis	hypothesis	NOUN
fnp-3459	110	14	to	to	PART
fnp-3459	110	15	explain	explain	VERB
fnp-3459	110	16	the	the	DET
fnp-3459	110	17	development	development	NOUN
fnp-3459	110	18	of	of	ADP
fnp-3459	110	19	ad	ad	NOUN
fnp-3459	110	20	which	which	PRON
fnp-3459	110	21	is	be	AUX
fnp-3459	110	22	coherent	coherent	ADJ
fnp-3459	110	23	and	and	CCONJ
fnp-3459	110	24	explains	explain	VERB
fnp-3459	110	25	many	many	ADJ
fnp-3459	110	26	facets	facet	NOUN
fnp-3459	110	27	of	of	ADP
fnp-3459	110	28	the	the	DET
fnp-3459	110	29	disease	disease	NOUN
fnp-3459	110	30	.	.	PUNCT
fnp-3459	111	1	it	it	PRON
fnp-3459	111	2	is	be	AUX
fnp-3459	111	3	important	important	ADJ
fnp-3459	111	4	to	to	PART
fnp-3459	111	5	emphasise	emphasise	VERB
fnp-3459	111	6	that	that	SCONJ
fnp-3459	111	7	a	a	DET
fnp-3459	111	8	hypothesis	hypothesis	NOUN
fnp-3459	111	9	is	be	AUX
fnp-3459	111	10	also	also	ADV
fnp-3459	111	11	an	an	DET
fnp-3459	111	12	extrapolation	extrapolation	NOUN
fnp-3459	111	13	of	of	ADP
fnp-3459	111	14	what	what	PRON
fnp-3459	111	15	is	be	AUX
fnp-3459	111	16	currently	currently	ADV
fnp-3459	111	17	known	know	VERB
fnp-3459	111	18	and	and	CCONJ
fnp-3459	111	19	so	so	ADV
fnp-3459	111	20	some	some	PRON
fnp-3459	111	21	of	of	ADP
fnp-3459	111	22	the	the	DET
fnp-3459	111	23	statements	statement	NOUN
fnp-3459	111	24	above	above	ADV
fnp-3459	111	25	are	be	AUX
fnp-3459	111	26	not	not	PART
fnp-3459	111	27	firmly	firmly	ADV
fnp-3459	111	28	established	establish	VERB
fnp-3459	111	29	but	but	CCONJ
fnp-3459	111	30	are	be	AUX
fnp-3459	111	31	potentially	potentially	ADV
fnp-3459	111	32	controversial	controversial	ADJ
fnp-3459	111	33	and	and	CCONJ
fnp-3459	111	34	remain	remain	VERB
fnp-3459	111	35	to	to	PART
fnp-3459	111	36	be	be	AUX
fnp-3459	111	37	explored	explore	VERB
fnp-3459	111	38	in	in	ADP
fnp-3459	111	39	the	the	DET
fnp-3459	111	40	testing	testing	NOUN
fnp-3459	111	41	of	of	ADP
fnp-3459	111	42	the	the	DET
fnp-3459	111	43	hypothesis	hypothesis	NOUN
fnp-3459	111	44	.	.	PUNCT
fnp-3459	112	1	potential	potential	ADJ
fnp-3459	112	2	thorns	thorn	NOUN
fnp-3459	112	3	in	in	ADP
fnp-3459	112	4	the	the	DET
fnp-3459	112	5	side	side	NOUN
fnp-3459	112	6	of	of	ADP
fnp-3459	112	7	this	this	DET
fnp-3459	112	8	hypothesis	hypothesis	NOUN
fnp-3459	112	9	include	include	VERB
fnp-3459	112	10	:	:	PUNCT
fnp-3459	112	11	localisation	localisation	NOUN
fnp-3459	112	12	of	of	ADP
fnp-3459	112	13	aβ	aβ	NOUN
fnp-3459	112	14	within	within	ADP
fnp-3459	112	15	apoe	apoe	NOUN
fnp-3459	112	16	-	-	PUNCT
fnp-3459	112	17	containing	contain	VERB
fnp-3459	112	18	lipoprotein	lipoprotein	ADJ
fnp-3459	112	19	particles	particle	NOUN
fnp-3459	112	20	has	have	AUX
fnp-3459	112	21	not	not	PART
fnp-3459	112	22	been	be	AUX
fnp-3459	112	23	directly	directly	ADV
fnp-3459	112	24	demonstrated	demonstrate	VERB
fnp-3459	112	25	in	in	ADP
fnp-3459	112	26	the	the	DET
fnp-3459	112	27	human	human	ADJ
fnp-3459	112	28	brain	brain	NOUN
fnp-3459	112	29	.	.	PUNCT
fnp-3459	113	1	this	this	PRON
fnp-3459	113	2	needs	need	VERB
fnp-3459	113	3	to	to	PART
fnp-3459	113	4	be	be	AUX
fnp-3459	113	5	explored	explore	VERB
fnp-3459	113	6	and	and	CCONJ
fnp-3459	113	7	represents	represent	VERB
fnp-3459	113	8	an	an	DET
fnp-3459	113	9	important	important	ADJ
fnp-3459	113	10	gap	gap	NOUN
fnp-3459	113	11	in	in	ADP
fnp-3459	113	12	our	our	PRON
fnp-3459	113	13	knowledge	knowledge	NOUN
fnp-3459	113	14	.	.	PUNCT
fnp-3459	114	1	available	available	ADJ
fnp-3459	114	2	technology	technology	NOUN
fnp-3459	114	3	is	be	AUX
fnp-3459	114	4	a	a	DET
fnp-3459	114	5	limitation	limitation	NOUN
fnp-3459	114	6	because	because	SCONJ
fnp-3459	114	7	the	the	DET
fnp-3459	114	8	lipoprotein	lipoprotein	ADJ
fnp-3459	114	9	particles	particle	NOUN
fnp-3459	114	10	are	be	AUX
fnp-3459	114	11	below	below	ADP
fnp-3459	114	12	the	the	DET
fnp-3459	114	13	resolution	resolution	NOUN
fnp-3459	114	14	of	of	ADP
fnp-3459	114	15	light	light	ADJ
fnp-3459	114	16	/	/	SYM
fnp-3459	114	17	confocal	confocal	ADJ
fnp-3459	114	18	microscopy	microscopy	NOUN
fnp-3459	114	19	but	but	CCONJ
fnp-3459	114	20	are	be	AUX
fnp-3459	114	21	potentially	potentially	ADV
fnp-3459	114	22	amenable	amenable	ADJ
fnp-3459	114	23	to	to	PART
fnp-3459	114	24	study	study	VERB
fnp-3459	114	25	by	by	ADP
fnp-3459	114	26	novel	novel	NOUN
fnp-3459	114	27	3d	3d	NUM
fnp-3459	114	28	electron	electron	NOUN
fnp-3459	114	29	microscopy	microscopy	NOUN
fnp-3459	114	30	methods	method	NOUN
fnp-3459	114	31	combined	combine	VERB
fnp-3459	114	32	with	with	ADP
fnp-3459	114	33	multilabel	multilabel	NOUN
fnp-3459	114	34	immunostaining	immunostaine	VERB
fnp-3459	114	35	.	.	PUNCT
fnp-3459	115	1	direct	direct	ADJ
fnp-3459	115	2	evidence	evidence	NOUN
fnp-3459	115	3	that	that	SCONJ
fnp-3459	115	4	lipoprotein	lipoprotein	ADJ
fnp-3459	115	5	particles	particle	NOUN
fnp-3459	115	6	become	become	VERB
fnp-3459	115	7	trapped	trapped	ADJ
fnp-3459	115	8	in	in	ADP
fnp-3459	115	9	the	the	DET
fnp-3459	115	10	extracellular	extracellular	ADJ
fnp-3459	115	11	space	space	NOUN
fnp-3459	115	12	,	,	PUNCT
fnp-3459	115	13	disintegrate	disintegrate	VERB
fnp-3459	115	14	and	and	CCONJ
fnp-3459	115	15	release	release	VERB
fnp-3459	115	16	aβ	aβ	NOUN
fnp-3459	115	17	is	be	AUX
fnp-3459	115	18	currently	currently	ADV
fnp-3459	115	19	lacking	lack	VERB
fnp-3459	115	20	.	.	PUNCT
fnp-3459	116	1	studies	study	NOUN
fnp-3459	116	2	of	of	ADP
fnp-3459	116	3	immunohistochemistry	immunohistochemistry	NOUN
fnp-3459	116	4	for	for	ADP
fnp-3459	116	5	aβ	aβ	PRON
fnp-3459	116	6	and	and	CCONJ
fnp-3459	116	7	apoe	apoe	PROPN
fnp-3459	116	8	identify	identify	VERB
fnp-3459	116	9	apoe	apoe	ADV
fnp-3459	116	10	in	in	ADP
fnp-3459	116	11	some	some	PRON
fnp-3459	116	12	,	,	PUNCT
fnp-3459	116	13	but	but	CCONJ
fnp-3459	116	14	not	not	PART
fnp-3459	116	15	all	all	DET
fnp-3459	116	16	plaques	plaque	NOUN
fnp-3459	116	17	.	.	PUNCT
fnp-3459	117	1	apoe	apoe	PROPN
fnp-3459	117	2	seems	seem	VERB
fnp-3459	117	3	to	to	PART
fnp-3459	117	4	be	be	AUX
fnp-3459	117	5	present	present	ADJ
fnp-3459	117	6	particularly	particularly	ADV
fnp-3459	117	7	in	in	ADP
fnp-3459	117	8	cored	cored	ADJ
fnp-3459	117	9	plaques	plaque	NOUN
fnp-3459	117	10	,	,	PUNCT
fnp-3459	117	11	which	which	PRON
fnp-3459	117	12	are	be	AUX
fnp-3459	117	13	interpreted	interpret	VERB
fnp-3459	117	14	as	as	ADP
fnp-3459	117	15	later	later	ADJ
fnp-3459	117	16	stage	stage	NOUN
fnp-3459	117	17	plaques	plaque	NOUN
fnp-3459	117	18	,	,	PUNCT
fnp-3459	117	19	rather	rather	ADV
fnp-3459	117	20	than	than	ADP
fnp-3459	117	21	early	early	ADJ
fnp-3459	117	22	diffuse	diffuse	NOUN
fnp-3459	117	23	plaques	plaque	NOUN
fnp-3459	117	24	as	as	SCONJ
fnp-3459	117	25	might	might	AUX
fnp-3459	117	26	be	be	AUX
fnp-3459	117	27	predicted	predict	VERB
fnp-3459	117	28	from	from	ADP
fnp-3459	117	29	the	the	DET
fnp-3459	117	30	hypothesis	hypothesis	NOUN
fnp-3459	117	31	.	.	PUNCT
fnp-3459	118	1	the	the	DET
fnp-3459	118	2	presence	presence	NOUN
fnp-3459	118	3	of	of	ADP
fnp-3459	118	4	apoe	apoe	NOUN
fnp-3459	118	5	in	in	ADP
fnp-3459	118	6	later	later	ADJ
fnp-3459	118	7	stage	stage	NOUN
fnp-3459	118	8	plaques	plaque	NOUN
fnp-3459	118	9	could	could	AUX
fnp-3459	118	10	possibly	possibly	ADV
fnp-3459	118	11	reflect	reflect	VERB
fnp-3459	118	12	involvement	involvement	NOUN
fnp-3459	118	13	of	of	ADP
fnp-3459	118	14	apoe	apoe	NOUN
fnp-3459	118	15	-	-	PUNCT
fnp-3459	118	16	containing	contain	VERB
fnp-3459	118	17	lipoprotein	lipoprotein	ADJ
fnp-3459	118	18	particles	particle	NOUN
fnp-3459	118	19	in	in	ADP
fnp-3459	118	20	attempted	attempt	VERB
fnp-3459	118	21	removal	removal	NOUN
fnp-3459	118	22	of	of	ADP
fnp-3459	118	23	aβ	aβ	NOUN
fnp-3459	118	24	,	,	PUNCT
fnp-3459	118	25	in	in	ADP
fnp-3459	118	26	addition	addition	NOUN
fnp-3459	118	27	to	to	ADP
fnp-3459	118	28	a	a	DET
fnp-3459	118	29	role	role	NOUN
fnp-3459	118	30	in	in	ADP
fnp-3459	118	31	plaque	plaque	NOUN
fnp-3459	118	32	formation	formation	NOUN
fnp-3459	118	33	.	.	PUNCT
fnp-3459	119	1	evidence	evidence	NOUN
fnp-3459	119	2	that	that	SCONJ
fnp-3459	119	3	high	high	ADJ
fnp-3459	119	4	peripheral	peripheral	ADJ
fnp-3459	119	5	cholesterol	cholesterol	NOUN
fnp-3459	119	6	levels	level	NOUN
fnp-3459	119	7	are	be	AUX
fnp-3459	119	8	associated	associate	VERB
fnp-3459	119	9	with	with	ADP
fnp-3459	119	10	increased	increase	VERB
fnp-3459	119	11	risk	risk	NOUN
fnp-3459	119	12	of	of	ADP
fnp-3459	119	13	ad	ad	NOUN
fnp-3459	119	14	and	and	CCONJ
fnp-3459	119	15	that	that	SCONJ
fnp-3459	119	16	statins	statin	NOUN
fnp-3459	119	17	,	,	PUNCT
fnp-3459	119	18	which	which	PRON
fnp-3459	119	19	reduce	reduce	VERB
fnp-3459	119	20	circulating	circulate	VERB
fnp-3459	119	21	cholesterol	cholesterol	NOUN
fnp-3459	119	22	by	by	ADP
fnp-3459	119	23	inhibiting	inhibit	VERB
fnp-3459	119	24	the	the	DET
fnp-3459	119	25	cholesterol	cholesterol	NOUN
fnp-3459	119	26	-	-	PUNCT
fnp-3459	119	27	synthesising	synthesise	VERB
fnp-3459	119	28	enzyme	enzyme	NOUN
fnp-3459	119	29	hmg	hmg	NOUN
fnp-3459	119	30	-	-	PUNCT
fnp-3459	119	31	coa	coa	NOUN
fnp-3459	119	32	reductase	reductase	NOUN
fnp-3459	119	33	,	,	PUNCT
fnp-3459	119	34	may	may	AUX
fnp-3459	119	35	reduce	reduce	VERB
fnp-3459	119	36	risk	risk	NOUN
fnp-3459	119	37	for	for	SCONJ
fnp-3459	119	38	ad	ad	NOUN
fnp-3459	119	39	[	[	X
fnp-3459	119	40	77	77	NUM
fnp-3459	119	41	]	]	PUNCT
fnp-3459	119	42	might	might	AUX
fnp-3459	119	43	seem	seem	VERB
fnp-3459	119	44	to	to	PART
fnp-3459	119	45	contradict	contradict	VERB
fnp-3459	119	46	the	the	DET
fnp-3459	119	47	hypothesis	hypothesis	NOUN
fnp-3459	119	48	presented	present	VERB
fnp-3459	119	49	here	here	ADV
fnp-3459	119	50	.	.	PUNCT
fnp-3459	120	1	it	it	PRON
fnp-3459	120	2	seems	seem	VERB
fnp-3459	120	3	that	that	SCONJ
fnp-3459	120	4	statins	statin	NOUN
fnp-3459	120	5	do	do	AUX
fnp-3459	120	6	reduce	reduce	VERB
fnp-3459	120	7	cholesterol	cholesterol	NOUN
fnp-3459	120	8	levels	level	NOUN
fnp-3459	120	9	in	in	ADP
fnp-3459	120	10	the	the	DET
fnp-3459	120	11	brain	brain	NOUN
fnp-3459	121	1	[	[	X
fnp-3459	121	2	78	78	NUM
fnp-3459	121	3	]	]	PUNCT
fnp-3459	121	4	.	.	PUNCT
fnp-3459	122	1	however	however	ADV
fnp-3459	122	2	,	,	PUNCT
fnp-3459	122	3	it	it	PRON
fnp-3459	122	4	may	may	AUX
fnp-3459	122	5	be	be	AUX
fnp-3459	122	6	that	that	SCONJ
fnp-3459	122	7	the	the	DET
fnp-3459	122	8	relative	relative	ADJ
fnp-3459	122	9	amounts	amount	NOUN
fnp-3459	122	10	of	of	ADP
fnp-3459	122	11	cholesterol	cholesterol	NOUN
fnp-3459	122	12	,	,	PUNCT
fnp-3459	122	13	aβ	aβ	NOUN
fnp-3459	122	14	and	and	CCONJ
fnp-3459	122	15	apoe	apoe	PROPN
fnp-3459	122	16	are	be	AUX
fnp-3459	122	17	important	important	ADJ
fnp-3459	122	18	i.e.	i.e.	ADV
fnp-3459	122	19	,	,	PUNCT
fnp-3459	122	20	that	that	SCONJ
fnp-3459	122	21	there	there	PRON
fnp-3459	122	22	is	be	VERB
fnp-3459	122	23	sufficient	sufficient	ADJ
fnp-3459	122	24	cholesterol	cholesterol	NOUN
fnp-3459	122	25	as	as	SCONJ
fnp-3459	122	26	required	require	VERB
fnp-3459	122	27	by	by	ADP
fnp-3459	122	28	neurons	neuron	NOUN
fnp-3459	122	29	,	,	PUNCT
fnp-3459	122	30	sufficient	sufficient	ADJ
fnp-3459	122	31	apoe	apoe	NOUN
fnp-3459	122	32	to	to	PART
fnp-3459	122	33	solubilise	solubilise	VERB
fnp-3459	122	34	the	the	DET
fnp-3459	122	35	cholesterol	cholesterol	NOUN
fnp-3459	122	36	and	and	CCONJ
fnp-3459	122	37	a	a	DET
fnp-3459	122	38	sufficient	sufficient	ADJ
fnp-3459	122	39	volume	volume	NOUN
fnp-3459	122	40	of	of	ADP
fnp-3459	122	41	lipophilic	lipophilic	ADJ
fnp-3459	122	42	core	core	NOUN
fnp-3459	122	43	within	within	ADP
fnp-3459	122	44	the	the	DET
fnp-3459	122	45	lipoprotein	lipoprotein	ADJ
fnp-3459	122	46	particles	particle	NOUN
fnp-3459	122	47	to	to	PART
fnp-3459	122	48	transport	transport	VERB
fnp-3459	122	49	aβ	aβ	NOUN
fnp-3459	122	50	and	and	CCONJ
fnp-3459	122	51	prevent	prevent	VERB
fnp-3459	122	52	its	its	PRON
fnp-3459	122	53	escape	escape	NOUN
fnp-3459	122	54	into	into	ADP
fnp-3459	122	55	the	the	DET
fnp-3459	122	56	aqueous	aqueous	ADJ
fnp-3459	122	57	environment	environment	NOUN
fnp-3459	122	58	of	of	ADP
fnp-3459	122	59	the	the	DET
fnp-3459	122	60	extracellular	extracellular	ADJ
fnp-3459	122	61	space	space	NOUN
fnp-3459	122	62	where	where	SCONJ
fnp-3459	122	63	it	it	PRON
fnp-3459	122	64	is	be	AUX
fnp-3459	122	65	prone	prone	ADJ
fnp-3459	122	66	to	to	PART
fnp-3459	122	67	aggregate	aggregate	VERB
fnp-3459	122	68	.	.	PUNCT
fnp-3459	123	1	therapeutic	therapeutic	ADJ
fnp-3459	123	2	consequences	consequence	NOUN
fnp-3459	123	3	over	over	ADP
fnp-3459	123	4	the	the	DET
fnp-3459	123	5	past	past	ADJ
fnp-3459	123	6	decades	decade	NOUN
fnp-3459	123	7	,	,	PUNCT
fnp-3459	123	8	human	human	ADJ
fnp-3459	123	9	clinical	clinical	ADJ
fnp-3459	123	10	trials	trial	NOUN
fnp-3459	123	11	of	of	ADP
fnp-3459	123	12	new	new	ADJ
fnp-3459	123	13	therapies	therapy	NOUN
fnp-3459	123	14	for	for	ADP
fnp-3459	123	15	ad	ad	NOUN
fnp-3459	123	16	have	have	AUX
fnp-3459	123	17	been	be	AUX
fnp-3459	123	18	unrelentingly	unrelentingly	ADV
fnp-3459	123	19	disappointing	disappointing	ADJ
fnp-3459	123	20	.	.	PUNCT
fnp-3459	124	1	this	this	PRON
fnp-3459	124	2	is	be	AUX
fnp-3459	124	3	despite	despite	SCONJ
fnp-3459	124	4	there	there	PRON
fnp-3459	124	5	being	be	AUX
fnp-3459	124	6	no	no	DET
fnp-3459	124	7	shortage	shortage	NOUN
fnp-3459	124	8	of	of	ADP
fnp-3459	124	9	endeavour	endeavour	NOUN
fnp-3459	124	10	and	and	CCONJ
fnp-3459	124	11	expenditure	expenditure	NOUN
fnp-3459	124	12	,	,	PUNCT
fnp-3459	124	13	and	and	CCONJ
fnp-3459	124	14	no	no	DET
fnp-3459	124	15	lack	lack	NOUN
fnp-3459	124	16	of	of	ADP
fnp-3459	124	17	successful	successful	ADJ
fnp-3459	124	18	therapeutic	therapeutic	ADJ
fnp-3459	124	19	studies	study	NOUN
fnp-3459	124	20	in	in	ADP
fnp-3459	124	21	animal	animal	NOUN
fnp-3459	124	22	models	model	NOUN
fnp-3459	124	23	of	of	ADP
fnp-3459	124	24	specific	specific	ADJ
fnp-3459	124	25	aspects	aspect	NOUN
fnp-3459	124	26	of	of	ADP
fnp-3459	124	27	ad	ad	NOUN
fnp-3459	124	28	.	.	PUNCT
fnp-3459	125	1	why	why	SCONJ
fnp-3459	125	2	is	be	AUX
fnp-3459	125	3	this	this	PRON
fnp-3459	125	4	?	?	PUNCT
fnp-3459	126	1	we	we	PRON
fnp-3459	126	2	suggest	suggest	VERB
fnp-3459	126	3	it	it	PRON
fnp-3459	126	4	is	be	AUX
fnp-3459	126	5	because	because	SCONJ
fnp-3459	126	6	the	the	DET
fnp-3459	126	7	wrong	wrong	ADJ
fnp-3459	126	8	targets	target	NOUN
fnp-3459	126	9	have	have	AUX
fnp-3459	126	10	been	be	AUX
fnp-3459	126	11	addressed	address	VERB
fnp-3459	126	12	.	.	PUNCT
fnp-3459	127	1	whereas	whereas	SCONJ
fnp-3459	127	2	each	each	PRON
fnp-3459	127	3	of	of	ADP
fnp-3459	127	4	the	the	DET
fnp-3459	127	5	major	major	ADJ
fnp-3459	127	6	suspects	suspect	NOUN
fnp-3459	127	7	listed	list	VERB
fnp-3459	127	8	above	above	ADV
fnp-3459	127	9	(	(	PUNCT
fnp-3459	127	10	aβ	aβ	PROPN
fnp-3459	127	11	,	,	PUNCT
fnp-3459	127	12	tau	tau	PROPN
fnp-3459	127	13	,	,	PUNCT
fnp-3459	127	14	glial	glial	ADJ
fnp-3459	127	15	cells	cell	NOUN
fnp-3459	127	16	)	)	PUNCT
fnp-3459	127	17	may	may	AUX
fnp-3459	127	18	exacerbate	exacerbate	VERB
fnp-3459	127	19	the	the	DET
fnp-3459	127	20	neurodegeneration	neurodegeneration	NOUN
fnp-3459	127	21	and	and	CCONJ
fnp-3459	127	22	set	set	VERB
fnp-3459	127	23	up	up	ADP
fnp-3459	127	24	self	self	NOUN
fnp-3459	127	25	-	-	PUNCT
fnp-3459	127	26	perpetuating	perpetuate	VERB
fnp-3459	127	27	vicious	vicious	ADJ
fnp-3459	127	28	cycles	cycle	NOUN
fnp-3459	127	29	,	,	PUNCT
fnp-3459	127	30	we	we	PRON
fnp-3459	127	31	propose	propose	VERB
fnp-3459	127	32	they	they	PRON
fnp-3459	127	33	are	be	AUX
fnp-3459	127	34	not	not	PART
fnp-3459	127	35	the	the	DET
fnp-3459	127	36	initiating	initiate	VERB
fnp-3459	127	37	factor	factor	NOUN
fnp-3459	127	38	in	in	ADP
fnp-3459	127	39	sporadic	sporadic	ADJ
fnp-3459	127	40	ad	ad	NOUN
fnp-3459	127	41	,	,	PUNCT
fnp-3459	127	42	either	either	CCONJ
fnp-3459	127	43	singly	singly	ADV
fnp-3459	127	44	or	or	CCONJ
fnp-3459	127	45	in	in	ADP
fnp-3459	127	46	combination	combination	NOUN
fnp-3459	127	47	.	.	PUNCT
fnp-3459	128	1	the	the	DET
fnp-3459	128	2	pathophysiological	pathophysiological	ADJ
fnp-3459	128	3	scheme	scheme	NOUN
fnp-3459	128	4	outlined	outline	VERB
fnp-3459	128	5	above	above	ADV
fnp-3459	128	6	indicates	indicate	VERB
fnp-3459	128	7	that	that	SCONJ
fnp-3459	128	8	,	,	PUNCT
fnp-3459	128	9	according	accord	VERB
fnp-3459	128	10	to	to	ADP
fnp-3459	128	11	this	this	DET
fnp-3459	128	12	hypothesis	hypothesis	NOUN
fnp-3459	128	13	,	,	PUNCT
fnp-3459	128	14	aβ	aβ	PRON
fnp-3459	128	15	and	and	CCONJ
fnp-3459	128	16	tau	tau	PROPN
fnp-3459	128	17	are	be	AUX
fnp-3459	128	18	not	not	PART
fnp-3459	128	19	the	the	DET
fnp-3459	128	20	cause	cause	NOUN
fnp-3459	128	21	of	of	ADP
fnp-3459	128	22	ad	ad	NOUN
fnp-3459	128	23	but	but	CCONJ
fnp-3459	128	24	are	be	AUX
fnp-3459	128	25	a	a	DET
fnp-3459	128	26	consequence	consequence	NOUN
fnp-3459	128	27	of	of	ADP
fnp-3459	128	28	the	the	DET
fnp-3459	128	29	primary	primary	ADJ
fnp-3459	128	30	abnormality	abnormality	NOUN
fnp-3459	128	31	,	,	PUNCT
fnp-3459	128	32	which	which	PRON
fnp-3459	128	33	is	be	AUX
fnp-3459	128	34	trapping	trap	VERB
fnp-3459	128	35	of	of	ADP
fnp-3459	128	36	lipoprotein	lipoprotein	ADJ
fnp-3459	128	37	particles	particle	NOUN
fnp-3459	128	38	in	in	ADP
fnp-3459	128	39	the	the	DET
fnp-3459	128	40	extracellular	extracellular	ADJ
fnp-3459	128	41	space	space	NOUN
fnp-3459	128	42	resulting	result	VERB
fnp-3459	128	43	in	in	ADP
fnp-3459	128	44	disruption	disruption	NOUN
fnp-3459	128	45	of	of	ADP
fnp-3459	128	46	the	the	DET
fnp-3459	128	47	normal	normal	ADJ
fnp-3459	128	48	system	system	NOUN
fnp-3459	128	49	of	of	ADP
fnp-3459	128	50	delivery	delivery	NOUN
fnp-3459	128	51	of	of	ADP
fnp-3459	128	52	cholesterol	cholesterol	NOUN
fnp-3459	128	53	to	to	ADP
fnp-3459	128	54	neurons	neuron	NOUN
fnp-3459	128	55	.	.	PUNCT
fnp-3459	129	1	this	this	PRON
fnp-3459	129	2	implies	imply	VERB
fnp-3459	129	3	that	that	SCONJ
fnp-3459	129	4	even	even	ADV
fnp-3459	129	5	if	if	SCONJ
fnp-3459	129	6	,	,	PUNCT
fnp-3459	129	7	for	for	ADP
fnp-3459	129	8	example	example	NOUN
fnp-3459	129	9	,	,	PUNCT
fnp-3459	129	10	the	the	DET
fnp-3459	129	11	ad	ad	NOUN
fnp-3459	129	12	brain	brain	NOUN
fnp-3459	129	13	can	can	AUX
fnp-3459	129	14	be	be	AUX
fnp-3459	129	15	completely	completely	ADV
fnp-3459	129	16	cleared	clear	VERB
fnp-3459	129	17	of	of	ADP
fnp-3459	129	18	aβ	aβ	DET
fnp-3459	129	19	plaques	plaque	NOUN
fnp-3459	129	20	,	,	PUNCT
fnp-3459	129	21	this	this	PRON
fnp-3459	129	22	will	will	AUX
fnp-3459	129	23	not	not	PART
fnp-3459	129	24	halt	halt	VERB
fnp-3459	129	25	the	the	DET
fnp-3459	129	26	neurodegenerative	neurodegenerative	ADJ
fnp-3459	129	27	decline	decline	NOUN
fnp-3459	129	28	as	as	SCONJ
fnp-3459	129	29	observed	observe	VERB
fnp-3459	129	30	first	first	ADV
fnp-3459	129	31	in	in	ADP
fnp-3459	129	32	the	the	DET
fnp-3459	129	33	long	long	ADJ
fnp-3459	129	34	-	-	PUNCT
fnp-3459	129	35	term	term	NOUN
fnp-3459	129	36	follow	follow	VERB
fnp-3459	129	37	up	up	ADP
fnp-3459	129	38	of	of	ADP
fnp-3459	129	39	ad	ad	NOUN
fnp-3459	129	40	patients	patient	NOUN
fnp-3459	129	41	immunised	immunise	VERB
fnp-3459	129	42	against	against	ADP
fnp-3459	129	43	aβ	aβ	NOUN
fnp-3459	129	44	using	use	VERB
fnp-3459	129	45	an1792	an1792	NOUN
fnp-3459	130	1	[	[	X
fnp-3459	130	2	79	79	NUM
fnp-3459	130	3	]	]	PUNCT
fnp-3459	130	4	and	and	CCONJ
fnp-3459	130	5	also	also	ADV
fnp-3459	130	6	in	in	ADP
fnp-3459	130	7	subsequent	subsequent	ADJ
fnp-3459	130	8	trials	trial	NOUN
fnp-3459	130	9	.	.	PUNCT
fnp-3459	131	1	instead	instead	ADV
fnp-3459	131	2	,	,	PUNCT
fnp-3459	131	3	therapy	therapy	NOUN
fnp-3459	131	4	for	for	ADP
fnp-3459	131	5	ad	ad	NOUN
fnp-3459	131	6	must	must	AUX
fnp-3459	131	7	be	be	AUX
fnp-3459	131	8	directed	direct	VERB
fnp-3459	131	9	at	at	ADP
fnp-3459	131	10	the	the	DET
fnp-3459	131	11	health	health	NOUN
fnp-3459	131	12	of	of	ADP
fnp-3459	131	13	the	the	DET
fnp-3459	131	14	extracellular	extracellular	ADJ
fnp-3459	131	15	space	space	NOUN
fnp-3459	131	16	,	,	PUNCT
fnp-3459	131	17	cholesterol	cholesterol	NOUN
fnp-3459	131	18	and	and	CCONJ
fnp-3459	131	19	apoe	apoe	ADJ
fnp-3459	131	20	,	,	PUNCT
fnp-3459	131	21	lubricating	lubricate	VERB
fnp-3459	131	22	the	the	DET
fnp-3459	131	23	passage	passage	NOUN
fnp-3459	131	24	of	of	ADP
fnp-3459	131	25	cholesterol	cholesterol	NOUN
fnp-3459	131	26	-	-	PUNCT
fnp-3459	131	27	containing	contain	VERB
fnp-3459	131	28	lipoprotein	lipoprotein	ADJ
fnp-3459	131	29	particles	particle	NOUN
fnp-3459	131	30	.	.	PUNCT
fnp-3459	132	1	references	reference	NOUN
fnp-3459	132	2	wolters	wolters	PROPN
fnp-3459	132	3	fj	fj	PROPN
fnp-3459	132	4	,	,	PUNCT
fnp-3459	132	5	yang	yang	PROPN
fnp-3459	132	6	q	q	PROPN
fnp-3459	132	7	,	,	PUNCT
fnp-3459	132	8	biggs	biggs	PROPN
fnp-3459	132	9	ml	ml	PROPN
fnp-3459	132	10	,	,	PUNCT
fnp-3459	132	11	jakobsdottir	jakobsdottir	PROPN
fnp-3459	132	12	j	j	PROPN
fnp-3459	132	13	,	,	PUNCT
fnp-3459	132	14	li	li	PROPN
fnp-3459	132	15	s	s	PROPN
fnp-3459	132	16	,	,	PUNCT
fnp-3459	132	17	evans	evans	PROPN
fnp-3459	132	18	ds	ds	PROPN
fnp-3459	132	19	,	,	PUNCT
fnp-3459	132	20	et	et	PROPN
fnp-3459	132	21	al	al	PROPN
fnp-3459	132	22	.	.	PUNCT
fnp-3459	133	1	the	the	DET
fnp-3459	133	2	impact	impact	NOUN
fnp-3459	133	3	of	of	ADP
fnp-3459	133	4	apoe	apoe	ADJ
fnp-3459	133	5	genotype	genotype	NOUN
fnp-3459	133	6	on	on	ADP
fnp-3459	133	7	survival	survival	NOUN
fnp-3459	133	8	:	:	PUNCT
fnp-3459	133	9	results	result	NOUN
fnp-3459	133	10	of	of	ADP
fnp-3459	133	11	38,537	38,537	NUM
fnp-3459	133	12	participants	participant	NOUN
fnp-3459	133	13	from	from	ADP
fnp-3459	133	14	six	six	NUM
fnp-3459	133	15	population	population	NOUN
fnp-3459	133	16	-	-	PUNCT
fnp-3459	133	17	based	base	VERB
fnp-3459	133	18	cohorts	cohort	NOUN
fnp-3459	133	19	(	(	PUNCT
fnp-3459	133	20	e2	e2	NOUN
fnp-3459	133	21	-	-	PUNCT
fnp-3459	133	22	charge	charge	NOUN
fnp-3459	133	23	)	)	PUNCT
fnp-3459	133	24	.	.	PUNCT
fnp-3459	134	1	plos	plos	PROPN
fnp-3459	134	2	one	one	NUM
fnp-3459	134	3	.	.	PUNCT
fnp-3459	135	1	2019;14(7):e0219668	2019;14(7):e0219668	X
fnp-3459	135	2	.	.	PUNCT
fnp-3459	135	3	https://doi.org/10.1371/journal.pone.0219668	https://doi.org/10.1371/journal.pone.0219668	PROPN
fnp-3459	135	4	corbo	corbo	PROPN
fnp-3459	135	5	rm	rm	PROPN
fnp-3459	135	6	,	,	PUNCT
fnp-3459	135	7	scacchi	scacchi	PROPN
fnp-3459	135	8	r.	r.	PROPN
fnp-3459	135	9	apolipoprotein	apolipoprotein	PROPN
fnp-3459	135	10	e	e	PROPN
fnp-3459	135	11	(	(	PUNCT
fnp-3459	135	12	apoe	apoe	ADJ
fnp-3459	135	13	)	)	PUNCT
fnp-3459	135	14	allele	allele	NOUN
fnp-3459	135	15	distribution	distribution	NOUN
fnp-3459	135	16	in	in	ADP
fnp-3459	135	17	the	the	DET
fnp-3459	135	18	world	world	NOUN
fnp-3459	135	19	.	.	PUNCT
fnp-3459	135	20	is	be	AUX
fnp-3459	135	21	apoe*4	apoe*4	NOUN
fnp-3459	135	22	a	a	DET
fnp-3459	135	23	'	'	PUNCT
fnp-3459	135	24	thrifty	thrifty	ADJ
fnp-3459	135	25	'	'	PUNCT
fnp-3459	135	26	allele	allele	NOUN
fnp-3459	135	27	?	?	PUNCT
fnp-3459	136	1	ann	ann	PROPN
fnp-3459	136	2	hum	hum	PROPN
fnp-3459	136	3	genet	genet	PROPN
fnp-3459	136	4	.	.	PUNCT
fnp-3459	137	1	1999;63(pt	1999;63(pt	NUM
fnp-3459	137	2	4):301	4):301	NUM
fnp-3459	137	3	-	-	PUNCT
fnp-3459	137	4	10	10	NUM
fnp-3459	137	5	.	.	PUNCT
fnp-3459	138	1	https://doi.org/10.1046/j.1469-1809.1999.6340301.x	https://doi.org/10.1046/j.1469-1809.1999.6340301.x	NOUN
fnp-3459	138	2	saunders	saunder	NOUN
fnp-3459	138	3	am	be	AUX
fnp-3459	138	4	,	,	PUNCT
fnp-3459	138	5	strittmatter	strittmatter	NOUN
fnp-3459	138	6	wj	wj	PROPN
fnp-3459	138	7	,	,	PUNCT
fnp-3459	138	8	schmechel	schmechel	PROPN
fnp-3459	138	9	d	d	PROPN
fnp-3459	138	10	,	,	PUNCT
fnp-3459	138	11	george	george	PROPN
fnp-3459	138	12	-	-	PUNCT
fnp-3459	138	13	hyslop	hyslop	NOUN
fnp-3459	138	14	ph	ph	VERB
fnp-3459	138	15	,	,	PUNCT
fnp-3459	138	16	pericak	pericak	ADJ
fnp-3459	138	17	-	-	PUNCT
fnp-3459	138	18	vance	vance	NOUN
fnp-3459	138	19	ma	ma	PROPN
fnp-3459	138	20	,	,	PUNCT
fnp-3459	138	21	joo	joo	PROPN
fnp-3459	138	22	sh	sh	PROPN
fnp-3459	138	23	,	,	PUNCT
fnp-3459	138	24	et	et	PROPN
fnp-3459	138	25	al	al	PROPN
fnp-3459	138	26	.	.	PROPN
fnp-3459	138	27	association	association	PROPN
fnp-3459	138	28	of	of	ADP
fnp-3459	138	29	apolipoprotein	apolipoprotein	ADJ
fnp-3459	138	30	e	e	PROPN
fnp-3459	138	31	allele	allele	PROPN
fnp-3459	138	32	epsilon	epsilon	PROPN
fnp-3459	138	33	4	4	NUM
fnp-3459	138	34	with	with	ADP
fnp-3459	138	35	late	late	ADJ
fnp-3459	138	36	-	-	PUNCT
fnp-3459	138	37	onset	onset	NOUN
fnp-3459	138	38	familial	familial	ADJ
fnp-3459	138	39	and	and	CCONJ
fnp-3459	138	40	sporadic	sporadic	ADJ
fnp-3459	138	41	alzheimer	alzheimer	PROPN
fnp-3459	138	42	's	's	PART
fnp-3459	138	43	disease	disease	NOUN
fnp-3459	138	44	.	.	PUNCT
fnp-3459	139	1	neurology	neurology	NOUN
fnp-3459	139	2	.	.	PUNCT
fnp-3459	140	1	1993;43(8):1467	1993;43(8):1467	PROPN
fnp-3459	140	2	-	-	SYM
fnp-3459	140	3	72	72	NUM
fnp-3459	140	4	.	.	PUNCT
fnp-3459	141	1	genin	genin	PROPN
fnp-3459	141	2	e	e	NOUN
fnp-3459	141	3	,	,	PUNCT
fnp-3459	141	4	hannequin	hannequin	PROPN
fnp-3459	141	5	d	d	PROPN
fnp-3459	141	6	,	,	PUNCT
fnp-3459	141	7	wallon	wallon	PROPN
fnp-3459	141	8	d	d	PROPN
fnp-3459	141	9	,	,	PUNCT
fnp-3459	141	10	sleegers	sleeger	NOUN
fnp-3459	141	11	k	k	PROPN
fnp-3459	141	12	,	,	PUNCT
fnp-3459	141	13	hiltunen	hiltunen	PROPN
fnp-3459	141	14	m	m	PROPN
fnp-3459	141	15	,	,	PUNCT
fnp-3459	141	16	combarros	combarros	PROPN
fnp-3459	141	17	o	o	NOUN
fnp-3459	141	18	,	,	PUNCT
fnp-3459	141	19	et	et	PROPN
fnp-3459	141	20	al	al	PROPN
fnp-3459	141	21	.	.	PROPN
fnp-3459	142	1	apoe	apoe	PROPN
fnp-3459	142	2	and	and	CCONJ
fnp-3459	142	3	alzheimer	alzheimer	PROPN
fnp-3459	142	4	disease	disease	PROPN
fnp-3459	142	5	:	:	PUNCT
fnp-3459	142	6	a	a	DET
fnp-3459	142	7	major	major	ADJ
fnp-3459	142	8	gene	gene	NOUN
fnp-3459	142	9	with	with	ADP
fnp-3459	142	10	semi	semi	ADJ
fnp-3459	142	11	-	-	ADJ
fnp-3459	142	12	dominant	dominant	ADJ
fnp-3459	142	13	inheritance	inheritance	NOUN
fnp-3459	142	14	.	.	PUNCT
fnp-3459	143	1	mol	mol	ADP
fnp-3459	143	2	psychiatry	psychiatry	NOUN
fnp-3459	143	3	.	.	PUNCT
fnp-3459	144	1	2011;16(9):903	2011;16(9):903	NUM
fnp-3459	144	2	-	-	SYM
fnp-3459	144	3	7	7	NUM
fnp-3459	144	4	.	.	NUM
fnp-3459	145	1	https://doi.org/10.1038/mp.2011.52	https://doi.org/10.1038/mp.2011.52	PROPN
fnp-3459	145	2	reiman	reiman	VERB
fnp-3459	145	3	em	em	PRON
fnp-3459	145	4	,	,	PUNCT
fnp-3459	145	5	arboleda	arboleda	PROPN
fnp-3459	145	6	-	-	PUNCT
fnp-3459	145	7	velasquez	velasquez	PROPN
fnp-3459	145	8	jf	jf	PROPN
fnp-3459	145	9	,	,	PUNCT
fnp-3459	145	10	quiroz	quiroz	PROPN
fnp-3459	145	11	yt	yt	PROPN
fnp-3459	145	12	,	,	PUNCT
fnp-3459	145	13	huentelman	huentelman	PROPN
fnp-3459	145	14	mj	mj	PROPN
fnp-3459	145	15	,	,	PUNCT
fnp-3459	145	16	beach	beach	PROPN
fnp-3459	145	17	tg	tg	PROPN
fnp-3459	145	18	,	,	PUNCT
fnp-3459	145	19	caselli	caselli	PROPN
fnp-3459	145	20	rj	rj	PROPN
fnp-3459	145	21	,	,	PUNCT
fnp-3459	145	22	et	et	PROPN
fnp-3459	145	23	al	al	PROPN
fnp-3459	145	24	.	.	PUNCT
fnp-3459	146	1	exceptionally	exceptionally	ADV
fnp-3459	146	2	low	low	ADJ
fnp-3459	146	3	likelihood	likelihood	NOUN
fnp-3459	146	4	of	of	ADP
fnp-3459	146	5	alzheimer	alzheimer	PROPN
fnp-3459	146	6	's	's	PART
fnp-3459	146	7	dementia	dementia	NOUN
fnp-3459	146	8	in	in	ADP
fnp-3459	146	9	apoe2	apoe2	PROPN
fnp-3459	146	10	homozygotes	homozygote	NOUN
fnp-3459	146	11	from	from	ADP
fnp-3459	146	12	a	a	DET
fnp-3459	146	13	5,000	5,000	NUM
fnp-3459	146	14	-	-	PUNCT
fnp-3459	146	15	person	person	NOUN
fnp-3459	146	16	neuropathological	neuropathological	ADJ
fnp-3459	146	17	study	study	NOUN
fnp-3459	146	18	.	.	PUNCT
fnp-3459	147	1	nat	nat	PROPN
fnp-3459	147	2	commun	commun	PROPN
fnp-3459	147	3	.	.	PUNCT
fnp-3459	148	1	2020;11(1):667	2020;11(1):667	NOUN
fnp-3459	148	2	.	.	PUNCT
fnp-3459	149	1	https://doi.org/10.1038/s41467-019-14279-8	https://doi.org/10.1038/s41467-019-14279-8	NUM
fnp-3459	149	2	zannis	zannis	PROPN
fnp-3459	149	3	vi	vi	PROPN
fnp-3459	149	4	,	,	PUNCT
fnp-3459	149	5	nicolosi	nicolosi	PROPN
fnp-3459	149	6	rj	rj	PROPN
fnp-3459	149	7	,	,	PUNCT
fnp-3459	149	8	jensen	jensen	PROPN
fnp-3459	149	9	e	e	PROPN
fnp-3459	149	10	,	,	PUNCT
fnp-3459	149	11	breslow	breslow	ADJ
fnp-3459	149	12	jl	jl	NOUN
fnp-3459	149	13	,	,	PUNCT
fnp-3459	149	14	hayes	hayes	PROPN
fnp-3459	149	15	kc	kc	PROPN
fnp-3459	149	16	.	.	PUNCT
fnp-3459	150	1	plasma	plasma	PROPN
fnp-3459	150	2	and	and	CCONJ
fnp-3459	150	3	hepatic	hepatic	ADJ
fnp-3459	150	4	apoe	apoe	ADJ
fnp-3459	150	5	isoproteins	isoprotein	NOUN
fnp-3459	150	6	of	of	ADP
fnp-3459	150	7	nonhuman	nonhuman	ADJ
fnp-3459	150	8	primates	primate	NOUN
fnp-3459	150	9	.	.	PUNCT
fnp-3459	151	1	differences	difference	NOUN
fnp-3459	151	2	in	in	ADP
fnp-3459	151	3	apoe	apoe	NOUN
fnp-3459	151	4	among	among	ADP
fnp-3459	151	5	humans	human	NOUN
fnp-3459	151	6	,	,	PUNCT
fnp-3459	151	7	apes	ape	NOUN
fnp-3459	151	8	,	,	PUNCT
fnp-3459	151	9	and	and	CCONJ
fnp-3459	151	10	new	new	ADJ
fnp-3459	151	11	and	and	CCONJ
fnp-3459	151	12	old	old	ADJ
fnp-3459	151	13	world	world	NOUN
fnp-3459	151	14	monkeys	monkey	NOUN
fnp-3459	151	15	.	.	PUNCT
fnp-3459	152	1	j	j	PROPN
fnp-3459	152	2	lipid	lipid	PROPN
fnp-3459	152	3	res	re	NOUN
fnp-3459	152	4	.	.	PUNCT
fnp-3459	153	1	1985;26(12):1421	1985;26(12):1421	NUM
fnp-3459	153	2	-	-	SYM
fnp-3459	153	3	30	30	NUM
fnp-3459	153	4	.	.	PUNCT
fnp-3459	154	1	mcintosh	mcintosh	PROPN
fnp-3459	154	2	am	am	PROPN
fnp-3459	154	3	,	,	PUNCT
fnp-3459	154	4	bennett	bennett	PROPN
fnp-3459	154	5	c	c	PROPN
fnp-3459	154	6	,	,	PUNCT
fnp-3459	154	7	dickson	dickson	PROPN
fnp-3459	154	8	d	d	PROPN
fnp-3459	154	9	,	,	PUNCT
fnp-3459	154	10	anestis	anestis	PROPN
fnp-3459	154	11	sf	sf	PROPN
fnp-3459	154	12	,	,	PUNCT
fnp-3459	154	13	watts	watts	PROPN
fnp-3459	154	14	dp	dp	PROPN
fnp-3459	154	15	,	,	PUNCT
fnp-3459	154	16	webster	webster	PROPN
fnp-3459	154	17	th	th	PROPN
fnp-3459	154	18	,	,	PUNCT
fnp-3459	154	19	et	et	PROPN
fnp-3459	154	20	al	al	PROPN
fnp-3459	154	21	.	.	PUNCT
fnp-3459	155	1	the	the	DET
fnp-3459	155	2	apolipoprotein	apolipoprotein	ADJ
fnp-3459	155	3	e	e	PROPN
fnp-3459	155	4	(	(	PUNCT
fnp-3459	155	5	apoe	apoe	ADJ
fnp-3459	155	6	)	)	PUNCT
fnp-3459	155	7	gene	gene	NOUN
fnp-3459	155	8	appears	appear	VERB
fnp-3459	155	9	functionally	functionally	ADV
fnp-3459	155	10	monomorphic	monomorphic	ADJ
fnp-3459	155	11	in	in	ADP
fnp-3459	155	12	chimpanzees	chimpanzee	NOUN
fnp-3459	155	13	(	(	PUNCT
fnp-3459	155	14	pan	pan	NOUN
fnp-3459	155	15	troglodytes	troglodyte	NOUN
fnp-3459	155	16	)	)	PUNCT
fnp-3459	155	17	.	.	PUNCT
fnp-3459	156	1	plos	plos	PROPN
fnp-3459	156	2	one	one	NUM
fnp-3459	156	3	.	.	PUNCT
fnp-3459	157	1	2012;7(10):e47760	2012;7(10):e47760	NOUN
fnp-3459	157	2	.	.	PUNCT
fnp-3459	158	1	https://doi.org/10.1371/journal.pone.0047760	https://doi.org/10.1371/journal.pone.0047760	PROPN
fnp-3459	158	2	poduri	poduri	NOUN
fnp-3459	158	3	a	a	X
fnp-3459	158	4	,	,	PUNCT
fnp-3459	158	5	gearing	gear	VERB
fnp-3459	158	6	m	m	PRON
fnp-3459	158	7	,	,	PUNCT
fnp-3459	158	8	rebeck	rebeck	PROPN
fnp-3459	158	9	gw	gw	PROPN
fnp-3459	158	10	,	,	PUNCT
fnp-3459	158	11	mirra	mirra	PROPN
fnp-3459	158	12	ss	ss	PROPN
fnp-3459	158	13	,	,	PUNCT
fnp-3459	158	14	tigges	tigge	VERB
fnp-3459	158	15	j	j	PROPN
fnp-3459	158	16	,	,	PUNCT
fnp-3459	158	17	hyman	hyman	PROPN
fnp-3459	158	18	bt	bt	PROPN
fnp-3459	158	19	.	.	PROPN
fnp-3459	158	20	apolipoprotein	apolipoprotein	PROPN
fnp-3459	158	21	e4	e4	PROPN
fnp-3459	158	22	and	and	CCONJ
fnp-3459	158	23	beta	beta	ADJ
fnp-3459	158	24	amyloid	amyloid	NOUN
fnp-3459	158	25	in	in	ADP
fnp-3459	158	26	senile	senile	ADJ
fnp-3459	158	27	plaques	plaque	NOUN
fnp-3459	158	28	and	and	CCONJ
fnp-3459	158	29	cerebral	cerebral	ADJ
fnp-3459	158	30	blood	blood	NOUN
fnp-3459	158	31	vessels	vessel	NOUN
fnp-3459	158	32	of	of	ADP
fnp-3459	158	33	aged	aged	ADJ
fnp-3459	158	34	rhesus	rhesus	NOUN
fnp-3459	158	35	monkeys	monkey	NOUN
fnp-3459	158	36	.	.	PUNCT
fnp-3459	159	1	am	be	AUX
fnp-3459	159	2	j	j	PROPN
fnp-3459	159	3	pathol	pathol	NOUN
fnp-3459	159	4	.	.	PUNCT
fnp-3459	160	1	1994;144(6):1183	1994;144(6):1183	NUM
fnp-3459	160	2	-	-	SYM
fnp-3459	160	3	7	7	NUM
fnp-3459	160	4	.	.	PUNCT
fnp-3459	161	1	dietschy	dietschy	PROPN
fnp-3459	161	2	jm	jm	PROPN
fnp-3459	161	3	,	,	PUNCT
fnp-3459	161	4	turley	turley	PROPN
fnp-3459	161	5	sd	sd	PROPN
fnp-3459	161	6	.	.	PUNCT
fnp-3459	162	1	thematic	thematic	ADJ
fnp-3459	162	2	review	review	NOUN
fnp-3459	162	3	series	series	NOUN
fnp-3459	162	4	:	:	PUNCT
fnp-3459	162	5	brain	brain	NOUN
fnp-3459	162	6	lipids	lipids	PROPN
fnp-3459	162	7	.	.	PUNCT
fnp-3459	163	1	cholesterol	cholesterol	NOUN
fnp-3459	163	2	metabolism	metabolism	NOUN
fnp-3459	163	3	in	in	ADP
fnp-3459	163	4	the	the	DET
fnp-3459	163	5	central	central	ADJ
fnp-3459	163	6	nervous	nervous	ADJ
fnp-3459	163	7	system	system	NOUN
fnp-3459	163	8	during	during	ADP
fnp-3459	163	9	early	early	ADJ
fnp-3459	163	10	development	development	NOUN
fnp-3459	163	11	and	and	CCONJ
fnp-3459	163	12	in	in	ADP
fnp-3459	163	13	the	the	DET
fnp-3459	163	14	mature	mature	ADJ
fnp-3459	163	15	animal	animal	NOUN
fnp-3459	163	16	.	.	PUNCT
fnp-3459	164	1	j	j	PROPN
fnp-3459	164	2	lipid	lipid	PROPN
fnp-3459	164	3	res	re	NOUN
fnp-3459	164	4	.	.	PUNCT
fnp-3459	165	1	2004;45(8):1375	2004;45(8):1375	NUM
fnp-3459	165	2	-	-	SYM
fnp-3459	165	3	97	97	NUM
fnp-3459	165	4	.	.	PUNCT
fnp-3459	166	1	https://doi.org/10.1194/jlr.r400004-jlr200	https://doi.org/10.1194/jlr.r400004-jlr200	NOUN
fnp-3459	166	2	poirier	poirier	PROPN
fnp-3459	166	3	j.	j.	PROPN
fnp-3459	166	4	apolipoprotein	apolipoprotein	PROPN
fnp-3459	166	5	e	e	PROPN
fnp-3459	166	6	and	and	CCONJ
fnp-3459	166	7	cholesterol	cholesterol	NOUN
fnp-3459	166	8	metabolism	metabolism	NOUN
fnp-3459	166	9	in	in	ADP
fnp-3459	166	10	the	the	DET
fnp-3459	166	11	pathogenesis	pathogenesis	NOUN
fnp-3459	166	12	and	and	CCONJ
fnp-3459	166	13	treatment	treatment	NOUN
fnp-3459	166	14	of	of	ADP
fnp-3459	166	15	alzheimer	alzheimer	PROPN
fnp-3459	166	16	's	's	PART
fnp-3459	166	17	disease	disease	NOUN
fnp-3459	166	18	.	.	PUNCT
fnp-3459	167	1	trends	trend	NOUN
fnp-3459	167	2	in	in	ADP
fnp-3459	167	3	molecular	molecular	ADJ
fnp-3459	167	4	medicine	medicine	NOUN
fnp-3459	167	5	.	.	PUNCT
fnp-3459	168	1	2003;9(3):94	2003;9(3):94	NUM
fnp-3459	168	2	-	-	SYM
fnp-3459	168	3	101	101	NUM
fnp-3459	168	4	.	.	PUNCT
fnp-3459	169	1	https://doi.org/10.1016/s1471-4914(03)00007-8	https://doi.org/10.1016/s1471-4914(03)00007-8	NOUN
fnp-3459	169	2	pfrieger	pfrieger	NOUN
fnp-3459	169	3	fw	fw	PROPN
fnp-3459	169	4	.	.	PROPN
fnp-3459	169	5	cholesterol	cholesterol	NOUN
fnp-3459	169	6	homeostasis	homeostasis	NOUN
fnp-3459	169	7	and	and	CCONJ
fnp-3459	169	8	function	function	NOUN
fnp-3459	169	9	in	in	ADP
fnp-3459	169	10	neurons	neuron	NOUN
fnp-3459	169	11	of	of	ADP
fnp-3459	169	12	the	the	DET
fnp-3459	169	13	central	central	ADJ
fnp-3459	169	14	nervous	nervous	ADJ
fnp-3459	169	15	system	system	NOUN
fnp-3459	169	16	.	.	PUNCT
fnp-3459	170	1	cell	cell	NOUN
fnp-3459	170	2	mol	mol	ADP
fnp-3459	170	3	life	life	PROPN
fnp-3459	170	4	sci	sci	PROPN
fnp-3459	170	5	.	.	PUNCT
fnp-3459	171	1	2003;60(6):1158	2003;60(6):1158	NUM
fnp-3459	171	2	-	-	SYM
fnp-3459	171	3	71	71	NUM
fnp-3459	171	4	.	.	PUNCT
fnp-3459	171	5	https://doi.org/10.1007/s00018-003-3018-7	https://doi.org/10.1007/s00018-003-3018-7	NUM
fnp-3459	171	6	jones	jones	PROPN
fnp-3459	171	7	l	l	PROPN
fnp-3459	171	8	,	,	PUNCT
fnp-3459	171	9	harold	harold	PROPN
fnp-3459	171	10	d	d	PROPN
fnp-3459	171	11	,	,	PUNCT
fnp-3459	171	12	williams	williams	PROPN
fnp-3459	171	13	j.	j.	PROPN
fnp-3459	171	14	genetic	genetic	ADJ
fnp-3459	171	15	evidence	evidence	NOUN
fnp-3459	171	16	for	for	ADP
fnp-3459	171	17	the	the	DET
fnp-3459	171	18	involvement	involvement	NOUN
fnp-3459	171	19	of	of	ADP
fnp-3459	171	20	lipid	lipid	ADJ
fnp-3459	171	21	metabolism	metabolism	NOUN
fnp-3459	171	22	in	in	ADP
fnp-3459	171	23	alzheimer	alzheimer	PROPN
fnp-3459	171	24	's	's	PART
fnp-3459	171	25	disease	disease	NOUN
fnp-3459	171	26	.	.	PUNCT
fnp-3459	172	1	biochim	biochim	PROPN
fnp-3459	172	2	biophys	biophy	NOUN
fnp-3459	172	3	acta	acta	PROPN
fnp-3459	172	4	.	.	PUNCT
fnp-3459	173	1	2010;1801(8):754	2010;1801(8):754	NUM
fnp-3459	173	2	-	-	SYM
fnp-3459	173	3	61	61	NUM
fnp-3459	173	4	.	.	PUNCT
fnp-3459	174	1	https://doi.org/10.1016/j.bbalip.2010.04.005	https://doi.org/10.1016/j.bbalip.2010.04.005	VERB
fnp-3459	174	2	hollingworth	hollingworth	NOUN
fnp-3459	174	3	p	p	NOUN
fnp-3459	174	4	,	,	PUNCT
fnp-3459	174	5	harold	harold	PROPN
fnp-3459	174	6	d	d	PROPN
fnp-3459	174	7	,	,	PUNCT
fnp-3459	174	8	sims	sim	NOUN
fnp-3459	174	9	r	r	NOUN
fnp-3459	174	10	,	,	PUNCT
fnp-3459	174	11	gerrish	gerrish	VERB
fnp-3459	174	12	a	a	PRON
fnp-3459	174	13	,	,	PUNCT
fnp-3459	174	14	lambert	lambert	PROPN
fnp-3459	174	15	jc	jc	PROPN
fnp-3459	174	16	,	,	PUNCT
fnp-3459	174	17	carrasquillo	carrasquillo	PROPN
fnp-3459	174	18	mm	mm	PROPN
fnp-3459	174	19	,	,	PUNCT
fnp-3459	174	20	et	et	PROPN
fnp-3459	174	21	al	al	PROPN
fnp-3459	174	22	.	.	PROPN
fnp-3459	175	1	common	common	ADJ
fnp-3459	175	2	variants	variant	NOUN
fnp-3459	175	3	at	at	ADP
fnp-3459	175	4	abca7	abca7	PROPN
fnp-3459	175	5	,	,	PUNCT
fnp-3459	175	6	ms4a6a	ms4a6a	PROPN
fnp-3459	175	7	/	/	SYM
fnp-3459	175	8	ms4a4e	ms4a4e	PROPN
fnp-3459	175	9	,	,	PUNCT
fnp-3459	175	10	epha1	epha1	PROPN
fnp-3459	175	11	,	,	PUNCT
fnp-3459	175	12	cd33	cd33	PROPN
fnp-3459	175	13	and	and	CCONJ
fnp-3459	175	14	cd2ap	cd2ap	NOUN
fnp-3459	175	15	are	be	AUX
fnp-3459	175	16	associated	associate	VERB
fnp-3459	175	17	with	with	ADP
fnp-3459	175	18	alzheimer	alzheimer	PROPN
fnp-3459	175	19	's	's	PART
fnp-3459	175	20	disease	disease	NOUN
fnp-3459	175	21	.	.	PUNCT
fnp-3459	176	1	nat	nat	PROPN
fnp-3459	176	2	genet	genet	PROPN
fnp-3459	176	3	.	.	PUNCT
fnp-3459	177	1	2011;43(5):429	2011;43(5):429	NUM
fnp-3459	177	2	-	-	SYM
fnp-3459	177	3	35	35	NUM
fnp-3459	177	4	.	.	PUNCT
fnp-3459	178	1	https://doi.org/10.1038/ng.803	https://doi.org/10.1038/ng.803	PROPN
fnp-3459	178	2	lamartiniere	lamartiniere	VERB
fnp-3459	178	3	y	y	PROPN
fnp-3459	178	4	,	,	PUNCT
fnp-3459	178	5	boucau	boucau	PROPN
fnp-3459	178	6	mc	mc	PROPN
fnp-3459	178	7	,	,	PUNCT
fnp-3459	178	8	dehouck	dehouck	VERB
fnp-3459	178	9	l	l	PROPN
fnp-3459	178	10	,	,	PUNCT
fnp-3459	178	11	krohn	krohn	PROPN
fnp-3459	178	12	m	m	PROPN
fnp-3459	178	13	,	,	PUNCT
fnp-3459	178	14	pahnke	pahnke	PROPN
fnp-3459	178	15	j	j	PROPN
fnp-3459	178	16	,	,	PUNCT
fnp-3459	178	17	candela	candela	NOUN
fnp-3459	178	18	p	p	NOUN
fnp-3459	178	19	,	,	PUNCT
fnp-3459	178	20	et	et	PROPN
fnp-3459	178	21	al	al	PROPN
fnp-3459	178	22	.	.	PUNCT
fnp-3459	179	1	abca7	abca7	PROPN
fnp-3459	179	2	downregulation	downregulation	NOUN
fnp-3459	179	3	modifies	modify	VERB
fnp-3459	179	4	cellular	cellular	ADJ
fnp-3459	179	5	cholesterol	cholesterol	NOUN
fnp-3459	179	6	homeostasis	homeostasis	NOUN
fnp-3459	179	7	and	and	CCONJ
fnp-3459	179	8	decreases	decrease	VERB
fnp-3459	179	9	amyloid	amyloid	NOUN
fnp-3459	179	10	-	-	PUNCT
fnp-3459	179	11	beta	beta	NOUN
fnp-3459	179	12	peptide	peptide	NOUN
fnp-3459	179	13	efflux	efflux	VERB
fnp-3459	179	14	in	in	ADP
fnp-3459	179	15	an	an	DET
fnp-3459	179	16	in	in	X
fnp-3459	179	17	vitro	vitro	X
fnp-3459	179	18	model	model	NOUN
fnp-3459	179	19	of	of	ADP
fnp-3459	179	20	the	the	DET
fnp-3459	179	21	blood	blood	NOUN
fnp-3459	179	22	-	-	PUNCT
fnp-3459	179	23	brain	brain	NOUN
fnp-3459	179	24	barrier	barrier	NOUN
fnp-3459	179	25	.	.	PUNCT
fnp-3459	180	1	j	j	PROPN
fnp-3459	180	2	alzheimers	alzheimers	PROPN
fnp-3459	180	3	dis	dis	PROPN
fnp-3459	180	4	.	.	PUNCT
fnp-3459	181	1	2018;64(4):1195	2018;64(4):1195	PROPN
fnp-3459	181	2	-	-	SYM
fnp-3459	181	3	211	211	NUM
fnp-3459	181	4	.	.	PUNCT
fnp-3459	182	1	https://doi.org/10.3233/jad-170883	https://doi.org/10.3233/jad-170883	PROPN
fnp-3459	183	1	dib	dib	PROPN
fnp-3459	183	2	s	s	PROPN
fnp-3459	183	3	,	,	PUNCT
fnp-3459	183	4	pahnke	pahnke	PROPN
fnp-3459	183	5	j	j	PROPN
fnp-3459	183	6	,	,	PUNCT
fnp-3459	183	7	gosselet	gosselet	ADJ
fnp-3459	183	8	f.	f.	PROPN
fnp-3459	183	9	role	role	NOUN
fnp-3459	183	10	of	of	ADP
fnp-3459	183	11	abca7	abca7	PROPN
fnp-3459	183	12	in	in	ADP
fnp-3459	183	13	human	human	ADJ
fnp-3459	183	14	health	health	NOUN
fnp-3459	183	15	and	and	CCONJ
fnp-3459	183	16	in	in	ADP
fnp-3459	183	17	alzheimer	alzheimer	PROPN
fnp-3459	183	18	's	's	PART
fnp-3459	183	19	disease	disease	NOUN
fnp-3459	183	20	.	.	PUNCT
fnp-3459	184	1	int	int	PROPN
fnp-3459	184	2	j	j	PROPN
fnp-3459	184	3	mol	mol	ADP
fnp-3459	184	4	sci	sci	PROPN
fnp-3459	184	5	.	.	PUNCT
fnp-3459	184	6	2021;22(9	2021;22(9	NUM
fnp-3459	184	7	)	)	PUNCT
fnp-3459	184	8	:	:	PUNCT
fnp-3459	184	9	4603	4603	NUM
fnp-3459	184	10	.	.	PUNCT
fnp-3459	185	1	https://doi.org/10.3390/ijms22094603	https://doi.org/10.3390/ijms22094603	PROPN
fnp-3459	185	2	wahrle	wahrle	PROPN
fnp-3459	185	3	se	se	PROPN
fnp-3459	185	4	,	,	PUNCT
fnp-3459	185	5	jiang	jiang	PROPN
fnp-3459	185	6	h	h	PROPN
fnp-3459	185	7	,	,	PUNCT
fnp-3459	185	8	parsadanian	parsadanian	PROPN
fnp-3459	185	9	m	m	PROPN
fnp-3459	185	10	,	,	PUNCT
fnp-3459	185	11	legleiter	legleiter	PROPN
fnp-3459	185	12	j	j	PROPN
fnp-3459	185	13	,	,	PUNCT
fnp-3459	185	14	han	han	PROPN
fnp-3459	185	15	x	x	PROPN
fnp-3459	185	16	,	,	PUNCT
fnp-3459	185	17	fryer	fryer	PROPN
fnp-3459	185	18	jd	jd	PROPN
fnp-3459	185	19	,	,	PUNCT
fnp-3459	185	20	et	et	PROPN
fnp-3459	185	21	al	al	PROPN
fnp-3459	185	22	.	.	PROPN
fnp-3459	185	23	abca1	abca1	PROPN
fnp-3459	185	24	is	be	AUX
fnp-3459	185	25	required	require	VERB
fnp-3459	185	26	for	for	ADP
fnp-3459	185	27	normal	normal	ADJ
fnp-3459	185	28	central	central	ADJ
fnp-3459	185	29	nervous	nervous	ADJ
fnp-3459	185	30	system	system	NOUN
fnp-3459	185	31	apoe	apoe	NOUN
fnp-3459	185	32	levels	level	NOUN
fnp-3459	185	33	and	and	CCONJ
fnp-3459	185	34	for	for	ADP
fnp-3459	185	35	lipidation	lipidation	NOUN
fnp-3459	185	36	of	of	ADP
fnp-3459	185	37	astrocyte	astrocyte	NOUN
fnp-3459	185	38	-	-	PUNCT
fnp-3459	185	39	secreted	secrete	VERB
fnp-3459	185	40	apoe	apoe	NOUN
fnp-3459	185	41	.	.	PUNCT
fnp-3459	186	1	j	j	PROPN
fnp-3459	186	2	biol	biol	PROPN
fnp-3459	186	3	chem	chem	NOUN
fnp-3459	186	4	.	.	PUNCT
fnp-3459	187	1	2004;279(39):40987	2004;279(39):40987	NUM
fnp-3459	187	2	-	-	SYM
fnp-3459	187	3	93	93	NUM
fnp-3459	187	4	.	.	PUNCT
fnp-3459	188	1	https://doi.org/10.1074/jbc.m407963200	https://doi.org/10.1074/jbc.m407963200	X
fnp-3459	188	2	ladu	ladu	PROPN
fnp-3459	188	3	mj	mj	PROPN
fnp-3459	188	4	,	,	PUNCT
fnp-3459	188	5	gilligan	gilligan	PROPN
fnp-3459	188	6	sm	sm	PROPN
fnp-3459	188	7	,	,	PUNCT
fnp-3459	188	8	lukens	lukens	PROPN
fnp-3459	188	9	jr	jr	PROPN
fnp-3459	188	10	,	,	PUNCT
fnp-3459	188	11	cabana	cabana	NOUN
fnp-3459	188	12	vg	vg	PROPN
fnp-3459	188	13	,	,	PUNCT
fnp-3459	188	14	reardon	reardon	PROPN
fnp-3459	188	15	ca	ca	PROPN
fnp-3459	188	16	,	,	PUNCT
fnp-3459	188	17	van	van	PROPN
fnp-3459	188	18	eldik	eldik	X
fnp-3459	189	1	lj	lj	PROPN
fnp-3459	189	2	,	,	PUNCT
fnp-3459	189	3	et	et	PROPN
fnp-3459	189	4	al	al	PROPN
fnp-3459	189	5	.	.	PUNCT
fnp-3459	189	6	nascent	nascent	ADJ
fnp-3459	189	7	astrocyte	astrocyte	NOUN
fnp-3459	189	8	particles	particle	NOUN
fnp-3459	189	9	differ	differ	VERB
fnp-3459	189	10	from	from	ADP
fnp-3459	189	11	lipoproteins	lipoprotein	NOUN
fnp-3459	189	12	in	in	ADP
fnp-3459	189	13	csf	csf	PROPN
fnp-3459	189	14	.	.	PROPN
fnp-3459	190	1	j	j	PROPN
fnp-3459	190	2	neurochem	neurochem	PROPN
fnp-3459	190	3	.	.	PUNCT
fnp-3459	191	1	1998;70(5):2070	1998;70(5):2070	NUM
fnp-3459	191	2	-	-	SYM
fnp-3459	191	3	81	81	NUM
fnp-3459	191	4	.	.	PUNCT
fnp-3459	192	1	https://doi.org/10.1046/j.1471-4159.1998.70052070.x	https://doi.org/10.1046/j.1471-4159.1998.70052070.x	PROPN
fnp-3459	192	2	lambert	lambert	PROPN
fnp-3459	192	3	jc	jc	PROPN
fnp-3459	192	4	,	,	PUNCT
fnp-3459	192	5	heath	heath	PROPN
fnp-3459	192	6	s	s	PROPN
fnp-3459	192	7	,	,	PUNCT
fnp-3459	192	8	even	even	ADV
fnp-3459	192	9	g	g	PROPN
fnp-3459	192	10	,	,	PUNCT
fnp-3459	192	11	campion	campion	NOUN
fnp-3459	192	12	d	d	PROPN
fnp-3459	192	13	,	,	PUNCT
fnp-3459	192	14	sleegers	sleeger	NOUN
fnp-3459	192	15	k	k	PROPN
fnp-3459	192	16	,	,	PUNCT
fnp-3459	192	17	hiltunen	hiltunen	PROPN
fnp-3459	192	18	m	m	PROPN
fnp-3459	192	19	,	,	PUNCT
fnp-3459	192	20	et	et	PROPN
fnp-3459	192	21	al	al	PROPN
fnp-3459	192	22	.	.	PUNCT
fnp-3459	192	23	genome	genome	NOUN
fnp-3459	192	24	-	-	PUNCT
fnp-3459	192	25	wide	wide	ADJ
fnp-3459	192	26	association	association	NOUN
fnp-3459	192	27	study	study	NOUN
fnp-3459	192	28	identifies	identify	VERB
fnp-3459	192	29	variants	variant	NOUN
fnp-3459	192	30	at	at	ADP
fnp-3459	192	31	clu	clu	PROPN
fnp-3459	192	32	and	and	CCONJ
fnp-3459	192	33	cr1	cr1	PROPN
fnp-3459	192	34	associated	associate	VERB
fnp-3459	192	35	with	with	ADP
fnp-3459	192	36	alzheimer	alzheimer	PROPN
fnp-3459	192	37	's	's	PART
fnp-3459	192	38	disease	disease	NOUN
fnp-3459	192	39	.	.	PUNCT
fnp-3459	193	1	nat	nat	PROPN
fnp-3459	193	2	genet	genet	PROPN
fnp-3459	193	3	.	.	PUNCT
fnp-3459	194	1	2009;41(10):1094	2009;41(10):1094	X
fnp-3459	194	2	-	-	SYM
fnp-3459	194	3	9	9	NUM
fnp-3459	194	4	.	.	PUNCT
fnp-3459	195	1	https://doi.org/10.1038/ng.439	https://doi.org/10.1038/ng.439	PROPN
fnp-3459	196	1	koch	koch	PROPN
fnp-3459	196	2	s	s	PROPN
fnp-3459	196	3	,	,	PUNCT
fnp-3459	196	4	donarski	donarski	PROPN
fnp-3459	196	5	n	n	CCONJ
fnp-3459	196	6	,	,	PUNCT
fnp-3459	196	7	goetze	goetze	PROPN
fnp-3459	196	8	k	k	PROPN
fnp-3459	196	9	,	,	PUNCT
fnp-3459	196	10	kreckel	kreckel	PROPN
fnp-3459	196	11	m	m	PROPN
fnp-3459	196	12	,	,	PUNCT
fnp-3459	196	13	stuerenburg	stuerenburg	PROPN
fnp-3459	196	14	h	h	PROPN
fnp-3459	196	15	-	-	PUNCT
fnp-3459	196	16	j	j	PROPN
fnp-3459	196	17	,	,	PUNCT
fnp-3459	196	18	buhmann	buhmann	PROPN
fnp-3459	196	19	c	c	X
fnp-3459	196	20	,	,	PUNCT
fnp-3459	196	21	et	et	PROPN
fnp-3459	196	22	al	al	PROPN
fnp-3459	196	23	.	.	PUNCT
fnp-3459	197	1	characterization	characterization	NOUN
fnp-3459	197	2	of	of	ADP
fnp-3459	197	3	four	four	NUM
fnp-3459	197	4	lipoprotein	lipoprotein	ADJ
fnp-3459	197	5	classes	class	NOUN
fnp-3459	197	6	in	in	ADP
fnp-3459	197	7	human	human	ADJ
fnp-3459	197	8	cerebrospinal	cerebrospinal	ADJ
fnp-3459	197	9	fluid	fluid	NOUN
fnp-3459	197	10	.	.	PUNCT
fnp-3459	198	1	journal	journal	NOUN
fnp-3459	198	2	of	of	ADP
fnp-3459	198	3	lipid	lipid	PROPN
fnp-3459	198	4	research	research	NOUN
fnp-3459	198	5	.	.	PUNCT
fnp-3459	199	1	2001;42(7):1143	2001;42(7):1143	PROPN
fnp-3459	199	2	-	-	SYM
fnp-3459	199	3	51	51	NUM
fnp-3459	199	4	.	.	PUNCT
fnp-3459	200	1	https://doi.org/10.1016/s0022-2275(20)31605-9	https://doi.org/10.1016/s0022-2275(20)31605-9	NOUN
fnp-3459	200	2	mahley	mahley	ADJ
fnp-3459	200	3	rw	rw	NOUN
fnp-3459	200	4	.	.	PUNCT
fnp-3459	201	1	central	central	ADJ
fnp-3459	201	2	nervous	nervous	ADJ
fnp-3459	201	3	system	system	NOUN
fnp-3459	201	4	lipoproteins	lipoprotein	VERB
fnp-3459	201	5	:	:	PUNCT
fnp-3459	201	6	apoe	apoe	NOUN
fnp-3459	201	7	and	and	CCONJ
fnp-3459	201	8	regulation	regulation	NOUN
fnp-3459	201	9	of	of	ADP
fnp-3459	201	10	cholesterol	cholesterol	NOUN
fnp-3459	201	11	metabolism	metabolism	NOUN
fnp-3459	201	12	.	.	PUNCT
fnp-3459	202	1	arterioscler	arterioscler	PROPN
fnp-3459	202	2	thromb	thromb	PROPN
fnp-3459	202	3	vasc	vasc	PROPN
fnp-3459	202	4	biol	biol	PROPN
fnp-3459	202	5	.	.	PUNCT
fnp-3459	203	1	2016;36(7):1305	2016;36(7):1305	X
fnp-3459	203	2	-	-	SYM
fnp-3459	203	3	15	15	NUM
fnp-3459	203	4	.	.	PUNCT
fnp-3459	204	1	https://doi.org/10.1161/atvbaha.116.307023	https://doi.org/10.1161/atvbaha.116.307023	PROPN
fnp-3459	204	2	linton	linton	PROPN
fnp-3459	204	3	mf	mf	PROPN
fnp-3459	204	4	,	,	PUNCT
fnp-3459	204	5	gish	gish	NOUN
fnp-3459	204	6	r	r	PROPN
fnp-3459	204	7	,	,	PUNCT
fnp-3459	204	8	hubl	hubl	PROPN
fnp-3459	204	9	st	st	PROPN
fnp-3459	204	10	,	,	PUNCT
fnp-3459	204	11	bütler	bütler	NOUN
fnp-3459	204	12	e	e	NOUN
fnp-3459	204	13	,	,	PUNCT
fnp-3459	204	14	esquivel	esquivel	PROPN
fnp-3459	204	15	c	c	PROPN
fnp-3459	204	16	,	,	PUNCT
fnp-3459	204	17	bry	bry	VERB
fnp-3459	204	18	wi	wi	PROPN
fnp-3459	204	19	,	,	PUNCT
fnp-3459	204	20	et	et	PROPN
fnp-3459	204	21	al	al	PROPN
fnp-3459	204	22	.	.	PUNCT
fnp-3459	205	1	phenotypes	phenotype	NOUN
fnp-3459	205	2	of	of	ADP
fnp-3459	205	3	apolipoprotein	apolipoprotein	ADJ
fnp-3459	205	4	b	b	PROPN
fnp-3459	205	5	and	and	CCONJ
fnp-3459	205	6	apolipoprotein	apolipoprotein	ADJ
fnp-3459	205	7	e	e	NOUN
fnp-3459	205	8	after	after	ADP
fnp-3459	205	9	liver	liver	NOUN
fnp-3459	205	10	transplantation	transplantation	NOUN
fnp-3459	205	11	.	.	PUNCT
fnp-3459	206	1	j	j	PROPN
fnp-3459	206	2	clin	clin	PROPN
fnp-3459	206	3	invest	invest	PROPN
fnp-3459	206	4	.	.	PUNCT
fnp-3459	207	1	1991;88(1):270	1991;88(1):270	NUM
fnp-3459	207	2	-	-	SYM
fnp-3459	207	3	81	81	NUM
fnp-3459	207	4	.	.	PUNCT
fnp-3459	208	1	https://doi.org/10.1172/jci115288	https://doi.org/10.1172/jci115288	ADJ
fnp-3459	208	2	stukas	stukas	PROPN
fnp-3459	208	3	s	s	PROPN
fnp-3459	208	4	,	,	PUNCT
fnp-3459	208	5	kulis	kulis	PROPN
fnp-3459	208	6	i	i	PRON
fnp-3459	208	7	,	,	PUNCT
fnp-3459	208	8	zareyan	zareyan	PROPN
fnp-3459	208	9	s	s	PROPN
fnp-3459	208	10	,	,	PUNCT
fnp-3459	208	11	wellington	wellington	PROPN
fnp-3459	208	12	cl	cl	NOUN
fnp-3459	208	13	.	.	PUNCT
fnp-3459	209	1	lipids	lipid	NOUN
fnp-3459	209	2	and	and	CCONJ
fnp-3459	209	3	lipoproteins	lipoprotein	NOUN
fnp-3459	209	4	in	in	ADP
fnp-3459	209	5	alzheimer	alzheimer	PROPN
fnp-3459	209	6	’s	’s	PART
fnp-3459	209	7	disease	disease	NOUN
fnp-3459	209	8	.	.	PUNCT
fnp-3459	210	1	in	in	ADP
fnp-3459	210	2	:	:	PUNCT
fnp-3459	210	3	zerr	zerr	PROPN
fnp-3459	210	4	i	i	PROPN
fnp-3459	210	5	,	,	PUNCT
fnp-3459	210	6	editor	editor	NOUN
fnp-3459	210	7	.	.	PUNCT
fnp-3459	211	1	alzheimer	alzheimer	PROPN
fnp-3459	211	2	's	's	PART
fnp-3459	211	3	disease	disease	NOUN
fnp-3459	211	4	challenges	challenge	VERB
fnp-3459	211	5	for	for	ADP
fnp-3459	211	6	the	the	DET
fnp-3459	211	7	future	future	NOUN
fnp-3459	211	8	:	:	PUNCT
fnp-3459	211	9	intechopen	intechopen	ADJ
fnp-3459	211	10	;	;	PUNCT
fnp-3459	211	11	2015	2015	NUM
fnp-3459	211	12	.	.	PUNCT
fnp-3459	212	1	nicholson	nicholson	PROPN
fnp-3459	212	2	c	c	PROPN
fnp-3459	212	3	,	,	PUNCT
fnp-3459	212	4	hrabetova	hrabetova	PROPN
fnp-3459	212	5	s.	s.	PROPN
fnp-3459	212	6	brain	brain	VERB
fnp-3459	212	7	extracellular	extracellular	ADJ
fnp-3459	212	8	space	space	NOUN
fnp-3459	212	9	:	:	PUNCT
fnp-3459	212	10	the	the	DET
fnp-3459	212	11	final	final	ADJ
fnp-3459	212	12	frontier	frontier	NOUN
fnp-3459	212	13	of	of	ADP
fnp-3459	212	14	neuroscience	neuroscience	NOUN
fnp-3459	212	15	.	.	PUNCT
fnp-3459	213	1	biophys	biophys	PROPN
fnp-3459	213	2	j.	j.	PROPN
fnp-3459	213	3	2017;113(10):2133	2017;113(10):2133	PROPN
fnp-3459	213	4	-	-	PROPN
fnp-3459	213	5	42	42	NUM
fnp-3459	213	6	.	.	PUNCT
fnp-3459	214	1	https://doi.org/10.1016/j.bpj.2017.06.052	https://doi.org/10.1016/j.bpj.2017.06.052	X
fnp-3459	214	2	nicholson	nicholson	PROPN
fnp-3459	214	3	c	c	PROPN
fnp-3459	214	4	,	,	PUNCT
fnp-3459	214	5	sykova	sykova	PROPN
fnp-3459	214	6	e.	e.	PROPN
fnp-3459	214	7	extracellular	extracellular	PROPN
fnp-3459	214	8	space	space	NOUN
fnp-3459	214	9	structure	structure	NOUN
fnp-3459	214	10	revealed	reveal	VERB
fnp-3459	214	11	by	by	ADP
fnp-3459	214	12	diffusion	diffusion	NOUN
fnp-3459	214	13	analysis	analysis	NOUN
fnp-3459	214	14	.	.	PUNCT
fnp-3459	215	1	trends	trend	NOUN
fnp-3459	215	2	neurosci	neurosci	PROPN
fnp-3459	215	3	.	.	PUNCT
fnp-3459	216	1	1998;21(5):207	1998;21(5):207	NOUN
fnp-3459	216	2	-	-	SYM
fnp-3459	216	3	15	15	NUM
fnp-3459	216	4	.	.	PUNCT
fnp-3459	217	1	https://doi.org/10.1016/s0166-2236(98)01261-2	https://doi.org/10.1016/s0166-2236(98)01261-2	PROPN
fnp-3459	217	2	ma	ma	PROPN
fnp-3459	217	3	j	j	PROPN
fnp-3459	217	4	,	,	PUNCT
fnp-3459	217	5	ma	ma	PROPN
fnp-3459	217	6	c	c	PROPN
fnp-3459	217	7	,	,	PUNCT
fnp-3459	217	8	li	li	PROPN
fnp-3459	217	9	j	j	PROPN
fnp-3459	217	10	,	,	PUNCT
fnp-3459	217	11	sun	sun	PROPN
fnp-3459	217	12	y	y	PROPN
fnp-3459	217	13	,	,	PUNCT
fnp-3459	217	14	ye	ye	PROPN
fnp-3459	217	15	f	f	PROPN
fnp-3459	217	16	,	,	PUNCT
fnp-3459	217	17	liu	liu	PROPN
fnp-3459	217	18	k	k	PROPN
fnp-3459	217	19	,	,	PUNCT
fnp-3459	217	20	et	et	PROPN
fnp-3459	217	21	al	al	PROPN
fnp-3459	217	22	.	.	PUNCT
fnp-3459	217	23	extracellular	extracellular	ADJ
fnp-3459	217	24	matrix	matrix	NOUN
fnp-3459	217	25	proteins	protein	NOUN
fnp-3459	217	26	involved	involve	VERB
fnp-3459	217	27	in	in	ADP
fnp-3459	217	28	alzheimer	alzheimer	PROPN
fnp-3459	217	29	's	's	PART
fnp-3459	217	30	disease	disease	NOUN
fnp-3459	217	31	.	.	PUNCT
fnp-3459	218	1	chemistry	chemistry	NOUN
fnp-3459	218	2	.	.	PUNCT
fnp-3459	219	1	2020;26(53):12101	2020;26(53):12101	NUM
fnp-3459	219	2	-	-	SYM
fnp-3459	219	3	10	10	NUM
fnp-3459	219	4	.	.	PUNCT
fnp-3459	220	1	https://doi.org/10.1002/chem.202000782	https://doi.org/10.1002/chem.202000782	PROPN
fnp-3459	220	2	martins	martin	VERB
fnp-3459	220	3	ij	ij	NOUN
fnp-3459	220	4	,	,	PUNCT
fnp-3459	220	5	berger	berger	PROPN
fnp-3459	220	6	t	t	PROPN
fnp-3459	220	7	,	,	PUNCT
fnp-3459	220	8	sharman	sharman	PROPN
fnp-3459	220	9	mj	mj	PROPN
fnp-3459	220	10	,	,	PUNCT
fnp-3459	220	11	verdile	verdile	NOUN
fnp-3459	220	12	g	g	NOUN
fnp-3459	220	13	,	,	PUNCT
fnp-3459	220	14	fuller	full	ADJ
fnp-3459	220	15	sj	sj	NOUN
fnp-3459	220	16	,	,	PUNCT
fnp-3459	220	17	martins	martins	PROPN
fnp-3459	220	18	rn	rn	PROPN
fnp-3459	220	19	.	.	PUNCT
fnp-3459	220	20	cholesterol	cholesterol	NOUN
fnp-3459	220	21	metabolism	metabolism	NOUN
fnp-3459	220	22	and	and	CCONJ
fnp-3459	220	23	transport	transport	NOUN
fnp-3459	220	24	in	in	ADP
fnp-3459	220	25	the	the	DET
fnp-3459	220	26	pathogenesis	pathogenesis	NOUN
fnp-3459	220	27	of	of	ADP
fnp-3459	220	28	alzheimer	alzheimer	PROPN
fnp-3459	220	29	's	's	PART
fnp-3459	220	30	disease	disease	NOUN
fnp-3459	220	31	.	.	PUNCT
fnp-3459	221	1	j	j	PROPN
fnp-3459	221	2	neurochem	neurochem	PROPN
fnp-3459	221	3	.	.	PUNCT
fnp-3459	222	1	2009;111(6):1275	2009;111(6):1275	NUM
fnp-3459	222	2	-	-	SYM
fnp-3459	222	3	308	308	NUM
fnp-3459	222	4	.	.	PUNCT
fnp-3459	222	5	https://doi.org/10.1111/j.1471-4159.2009.06408.x	https://doi.org/10.1111/j.1471-4159.2009.06408.x	ADJ
fnp-3459	222	6	beffert	beffert	PROPN
fnp-3459	222	7	u	u	PROPN
fnp-3459	222	8	,	,	PUNCT
fnp-3459	222	9	poirier	poirier	PROPN
fnp-3459	222	10	j.	j.	PROPN
fnp-3459	222	11	apolipoprotein	apolipoprotein	PROPN
fnp-3459	222	12	e	e	PROPN
fnp-3459	222	13	,	,	PUNCT
fnp-3459	222	14	plaques	plaque	NOUN
fnp-3459	222	15	,	,	PUNCT
fnp-3459	222	16	tangles	tangle	NOUN
fnp-3459	222	17	and	and	CCONJ
fnp-3459	222	18	cholinergic	cholinergic	ADJ
fnp-3459	222	19	dysfunction	dysfunction	NOUN
fnp-3459	222	20	in	in	ADP
fnp-3459	222	21	alzheimer	alzheimer	PROPN
fnp-3459	222	22	's	's	PART
fnp-3459	222	23	disease	disease	NOUN
fnp-3459	222	24	.	.	PUNCT
fnp-3459	223	1	ann	ann	PROPN
fnp-3459	223	2	n	n	PROPN
fnp-3459	223	3	y	y	PROPN
fnp-3459	223	4	acad	acad	PROPN
fnp-3459	223	5	sci	sci	PROPN
fnp-3459	223	6	.	.	PROPN
fnp-3459	224	1	1996;777:166	1996;777:166	NUM
fnp-3459	224	2	-	-	SYM
fnp-3459	224	3	74	74	NUM
fnp-3459	224	4	.	.	PUNCT
fnp-3459	225	1	https://doi.org/10.1111/j.1749-6632.1996.tb34415.x	https://doi.org/10.1111/j.1749-6632.1996.tb34415.x	PROPN
fnp-3459	225	2	biere	biere	PROPN
fnp-3459	225	3	al	al	PROPN
fnp-3459	225	4	,	,	PUNCT
fnp-3459	225	5	ostaszewski	ostaszewski	PROPN
fnp-3459	225	6	b	b	PROPN
fnp-3459	225	7	,	,	PUNCT
fnp-3459	225	8	stimson	stimson	PROPN
fnp-3459	225	9	er	er	INTJ
fnp-3459	225	10	,	,	PUNCT
fnp-3459	225	11	hyman	hyman	PROPN
fnp-3459	225	12	bt	bt	PROPN
fnp-3459	225	13	,	,	PUNCT
fnp-3459	225	14	maggio	maggio	PROPN
fnp-3459	225	15	je	je	PROPN
fnp-3459	225	16	,	,	PUNCT
fnp-3459	225	17	selkoe	selkoe	PROPN
fnp-3459	225	18	dj	dj	X
fnp-3459	225	19	.	.	PUNCT
fnp-3459	225	20	amyloid	amyloid	NOUN
fnp-3459	225	21	beta	beta	NOUN
fnp-3459	225	22	-	-	PUNCT
fnp-3459	225	23	peptide	peptide	NOUN
fnp-3459	225	24	is	be	AUX
fnp-3459	225	25	transported	transport	VERB
fnp-3459	225	26	on	on	ADP
fnp-3459	225	27	lipoproteins	lipoprotein	NOUN
fnp-3459	225	28	and	and	CCONJ
fnp-3459	225	29	albumin	albumin	NOUN
fnp-3459	225	30	in	in	ADP
fnp-3459	225	31	human	human	ADJ
fnp-3459	225	32	plasma	plasma	NOUN
fnp-3459	225	33	.	.	PUNCT
fnp-3459	226	1	j	j	PROPN
fnp-3459	226	2	biol	biol	PROPN
fnp-3459	226	3	chem	chem	NOUN
fnp-3459	226	4	.	.	PUNCT
fnp-3459	227	1	1996;271(51):32916	1996;271(51):32916	NUM
fnp-3459	227	2	-	-	SYM
fnp-3459	227	3	22	22	NUM
fnp-3459	227	4	.	.	PUNCT
fnp-3459	228	1	https://doi.org/10.1074/jbc.271.51.32916	https://doi.org/10.1074/jbc.271.51.32916	PROPN
fnp-3459	228	2	cole	cole	PROPN
fnp-3459	228	3	gm	gm	PROPN
fnp-3459	228	4	,	,	PUNCT
fnp-3459	228	5	ard	ard	PROPN
fnp-3459	228	6	md	md	PROPN
fnp-3459	228	7	.	.	PUNCT
fnp-3459	229	1	influence	influence	NOUN
fnp-3459	229	2	of	of	ADP
fnp-3459	229	3	lipoproteins	lipoprotein	NOUN
fnp-3459	229	4	on	on	ADP
fnp-3459	229	5	microglial	microglial	ADJ
fnp-3459	229	6	degradation	degradation	NOUN
fnp-3459	229	7	of	of	ADP
fnp-3459	229	8	alzheimer	alzheimer	PROPN
fnp-3459	229	9	's	's	PART
fnp-3459	229	10	amyloid	amyloid	NOUN
fnp-3459	229	11	beta	beta	NOUN
fnp-3459	229	12	-	-	PUNCT
fnp-3459	229	13	protein	protein	NOUN
fnp-3459	229	14	.	.	PUNCT
fnp-3459	230	1	microsc	microsc	ADJ
fnp-3459	230	2	res	re	NOUN
fnp-3459	230	3	tech	tech	NOUN
fnp-3459	230	4	.	.	PUNCT
fnp-3459	231	1	2000;50(4):316	2000;50(4):316	NUM
fnp-3459	231	2	-	-	SYM
fnp-3459	231	3	24	24	NUM
fnp-3459	231	4	.	.	PUNCT
fnp-3459	232	1	https://doi.org/10.1002/1097-0029(20000815)50:4%3c316::aid-jemt11%3e3.0.co;2-e	https://doi.org/10.1002/1097-0029(20000815)50:4%3c316::aid-jemt11%3e3.0.co;2-e	PROPN
fnp-3459	232	2	tamamizu	tamamizu	PROPN
fnp-3459	232	3	-	-	PUNCT
fnp-3459	232	4	kato	kato	PROPN
fnp-3459	232	5	s	s	PROPN
fnp-3459	232	6	,	,	PUNCT
fnp-3459	232	7	cohen	cohen	PROPN
fnp-3459	232	8	jk	jk	PROPN
fnp-3459	232	9	,	,	PUNCT
fnp-3459	232	10	drake	drake	PROPN
fnp-3459	232	11	cb	cb	PROPN
fnp-3459	232	12	,	,	PUNCT
fnp-3459	232	13	kosaraju	kosaraju	PROPN
fnp-3459	232	14	mg	mg	PROPN
fnp-3459	232	15	,	,	PUNCT
fnp-3459	232	16	drury	drury	PROPN
fnp-3459	232	17	j	j	PROPN
fnp-3459	232	18	,	,	PUNCT
fnp-3459	232	19	narayanaswami	narayanaswami	PROPN
fnp-3459	232	20	v.	v.	ADP
fnp-3459	232	21	interaction	interaction	NOUN
fnp-3459	232	22	with	with	ADP
fnp-3459	232	23	amyloid	amyloid	NOUN
fnp-3459	232	24	beta	beta	NOUN
fnp-3459	232	25	peptide	peptide	NOUN
fnp-3459	232	26	compromises	compromise	VERB
fnp-3459	232	27	the	the	DET
fnp-3459	232	28	lipid	lipid	NOUN
fnp-3459	232	29	binding	bind	VERB
fnp-3459	232	30	function	function	NOUN
fnp-3459	232	31	of	of	ADP
fnp-3459	232	32	apolipoprotein	apolipoprotein	ADJ
fnp-3459	232	33	e.	e.	PROPN
fnp-3459	232	34	biochemistry	biochemistry	PROPN
fnp-3459	232	35	.	.	PUNCT
fnp-3459	233	1	2008;47(18):5225	2008;47(18):5225	NUM
fnp-3459	233	2	-	-	SYM
fnp-3459	233	3	34	34	NUM
fnp-3459	233	4	.	.	PUNCT
fnp-3459	234	1	https://doi.org/10.1021/bi702097s	https://doi.org/10.1021/bi702097s	PROPN
fnp-3459	234	2	arold	arold	PROPN
fnp-3459	234	3	s	s	PROPN
fnp-3459	234	4	,	,	PUNCT
fnp-3459	234	5	sullivan	sullivan	PROPN
fnp-3459	234	6	p	p	PROPN
fnp-3459	234	7	,	,	PUNCT
fnp-3459	234	8	bilousova	bilousova	PROPN
fnp-3459	234	9	t	t	PROPN
fnp-3459	234	10	,	,	PUNCT
fnp-3459	234	11	teng	teng	PROPN
fnp-3459	234	12	e	e	PROPN
fnp-3459	234	13	,	,	PUNCT
fnp-3459	234	14	miller	miller	PROPN
fnp-3459	234	15	ca	ca	PROPN
fnp-3459	234	16	,	,	PUNCT
fnp-3459	234	17	poon	poon	NOUN
fnp-3459	234	18	ww	ww	PROPN
fnp-3459	234	19	,	,	PUNCT
fnp-3459	234	20	et	et	PROPN
fnp-3459	234	21	al	al	PROPN
fnp-3459	234	22	.	.	PROPN
fnp-3459	235	1	apolipoprotein	apolipoprotein	PROPN
fnp-3459	235	2	e	e	NOUN
fnp-3459	235	3	level	level	NOUN
fnp-3459	235	4	and	and	CCONJ
fnp-3459	235	5	cholesterol	cholesterol	NOUN
fnp-3459	235	6	are	be	AUX
fnp-3459	235	7	associated	associate	VERB
fnp-3459	235	8	with	with	ADP
fnp-3459	235	9	reduced	reduce	VERB
fnp-3459	235	10	synaptic	synaptic	ADJ
fnp-3459	235	11	amyloid	amyloid	NOUN
fnp-3459	235	12	beta	beta	NOUN
fnp-3459	235	13	in	in	ADP
fnp-3459	235	14	alzheimer	alzheimer	PROPN
fnp-3459	235	15	's	's	PART
fnp-3459	235	16	disease	disease	NOUN
fnp-3459	235	17	and	and	CCONJ
fnp-3459	235	18	apoe	apoe	ADJ
fnp-3459	235	19	tr	tr	PROPN
fnp-3459	235	20	mouse	mouse	NOUN
fnp-3459	235	21	cortex	cortex	NOUN
fnp-3459	235	22	.	.	PUNCT
fnp-3459	236	1	acta	acta	PROPN
fnp-3459	236	2	neuropathol	neuropathol	PROPN
fnp-3459	236	3	.	.	PUNCT
fnp-3459	237	1	2012;123(1):39	2012;123(1):39	NUM
fnp-3459	237	2	-	-	SYM
fnp-3459	237	3	52	52	NUM
fnp-3459	237	4	.	.	PUNCT
fnp-3459	238	1	https://doi.org/10.1007/s00401-011-0892-1	https://doi.org/10.1007/s00401-011-0892-1	PROPN
fnp-3459	238	2	yamaguchi	yamaguchi	PROPN
fnp-3459	238	3	h	h	PROPN
fnp-3459	238	4	,	,	PUNCT
fnp-3459	238	5	nakazato	nakazato	PROPN
fnp-3459	238	6	y	y	PROPN
fnp-3459	238	7	,	,	PUNCT
fnp-3459	238	8	hirai	hirai	PROPN
fnp-3459	238	9	s	s	PROPN
fnp-3459	238	10	,	,	PUNCT
fnp-3459	238	11	shoji	shoji	PROPN
fnp-3459	238	12	m	m	PROPN
fnp-3459	238	13	,	,	PUNCT
fnp-3459	238	14	harigaya	harigaya	PROPN
fnp-3459	238	15	y.	y.	PROPN
fnp-3459	238	16	electron	electron	PROPN
fnp-3459	238	17	micrograph	micrograph	NOUN
fnp-3459	238	18	of	of	ADP
fnp-3459	238	19	diffuse	diffuse	ADJ
fnp-3459	238	20	plaques	plaque	NOUN
fnp-3459	238	21	.	.	PUNCT
fnp-3459	239	1	initial	initial	ADJ
fnp-3459	239	2	stage	stage	NOUN
fnp-3459	239	3	of	of	ADP
fnp-3459	239	4	senile	senile	ADJ
fnp-3459	239	5	plaque	plaque	NOUN
fnp-3459	239	6	formation	formation	NOUN
fnp-3459	239	7	in	in	ADP
fnp-3459	239	8	the	the	DET
fnp-3459	239	9	alzheimer	alzheimer	PROPN
fnp-3459	239	10	brain	brain	NOUN
fnp-3459	239	11	.	.	PUNCT
fnp-3459	240	1	am	be	AUX
fnp-3459	240	2	j	j	PROPN
fnp-3459	240	3	pathol	pathol	NOUN
fnp-3459	240	4	.	.	PUNCT
fnp-3459	241	1	1989;135(4):593	1989;135(4):593	NUM
fnp-3459	241	2	-	-	SYM
fnp-3459	241	3	7	7	NUM
fnp-3459	241	4	.	.	PUNCT
fnp-3459	241	5	bales	bale	NOUN
fnp-3459	241	6	kr	kr	PROPN
fnp-3459	241	7	,	,	PUNCT
fnp-3459	241	8	verina	verina	PROPN
fnp-3459	241	9	t	t	PROPN
fnp-3459	241	10	,	,	PUNCT
fnp-3459	241	11	cummins	cummins	PROPN
fnp-3459	241	12	dj	dj	PROPN
fnp-3459	241	13	,	,	PUNCT
fnp-3459	241	14	du	du	PROPN
fnp-3459	241	15	y	y	PROPN
fnp-3459	241	16	,	,	PUNCT
fnp-3459	241	17	dodel	dodel	PROPN
fnp-3459	241	18	rc	rc	PROPN
fnp-3459	241	19	,	,	PUNCT
fnp-3459	241	20	saura	saura	PROPN
fnp-3459	241	21	j	j	PROPN
fnp-3459	241	22	,	,	PUNCT
fnp-3459	241	23	et	et	PROPN
fnp-3459	241	24	al	al	PROPN
fnp-3459	241	25	.	.	PROPN
fnp-3459	242	1	apolipoprotein	apolipoprotein	PROPN
fnp-3459	242	2	e	e	PROPN
fnp-3459	242	3	is	be	AUX
fnp-3459	242	4	essential	essential	ADJ
fnp-3459	242	5	for	for	ADP
fnp-3459	242	6	amyloid	amyloid	NOUN
fnp-3459	242	7	deposition	deposition	NOUN
fnp-3459	242	8	in	in	ADP
fnp-3459	242	9	the	the	DET
fnp-3459	242	10	app(v717f	app(v717f	PROPN
fnp-3459	242	11	)	)	PUNCT
fnp-3459	242	12	transgenic	transgenic	NOUN
fnp-3459	242	13	mouse	mouse	NOUN
fnp-3459	242	14	model	model	NOUN
fnp-3459	242	15	of	of	ADP
fnp-3459	242	16	alzheimer	alzheimer	PROPN
fnp-3459	242	17	's	's	PART
fnp-3459	242	18	disease	disease	NOUN
fnp-3459	242	19	.	.	PUNCT
fnp-3459	243	1	proc	proc	PROPN
fnp-3459	243	2	natl	natl	PROPN
fnp-3459	243	3	acad	acad	PROPN
fnp-3459	243	4	sci	sci	PROPN
fnp-3459	243	5	u	u	PROPN
fnp-3459	243	6	s	s	NOUN
fnp-3459	243	7	a.	a.	NOUN
fnp-3459	243	8	1999;96(26):15233	1999;96(26):15233	NUM
fnp-3459	243	9	-	-	SYM
fnp-3459	243	10	8	8	NUM
fnp-3459	243	11	.	.	PUNCT
fnp-3459	243	12	https://doi.org/10.1073/pnas.96.26.15233	https://doi.org/10.1073/pnas.96.26.15233	PROPN
fnp-3459	243	13	soderberg	soderberg	PROPN
fnp-3459	243	14	m	m	PROPN
fnp-3459	243	15	,	,	PUNCT
fnp-3459	243	16	edlund	edlund	PROPN
fnp-3459	243	17	c	c	PROPN
fnp-3459	243	18	,	,	PUNCT
fnp-3459	243	19	kristensson	kristensson	NOUN
fnp-3459	243	20	k	k	NOUN
fnp-3459	243	21	,	,	PUNCT
fnp-3459	243	22	dallner	dallner	NOUN
fnp-3459	243	23	g.	g.	PROPN
fnp-3459	243	24	lipid	lipid	PROPN
fnp-3459	243	25	compositions	composition	NOUN
fnp-3459	243	26	of	of	ADP
fnp-3459	243	27	different	different	ADJ
fnp-3459	243	28	regions	region	NOUN
fnp-3459	243	29	of	of	ADP
fnp-3459	243	30	the	the	DET
fnp-3459	243	31	human	human	ADJ
fnp-3459	243	32	brain	brain	NOUN
fnp-3459	243	33	during	during	ADP
fnp-3459	243	34	aging	aging	NOUN
fnp-3459	243	35	.	.	PUNCT
fnp-3459	244	1	j	j	PROPN
fnp-3459	244	2	neurochem	neurochem	PROPN
fnp-3459	244	3	.	.	PUNCT
fnp-3459	245	1	1990;54(2):415	1990;54(2):415	NUM
fnp-3459	245	2	-	-	PUNCT
fnp-3459	245	3	23	23	NUM
fnp-3459	245	4	.	.	PUNCT
fnp-3459	246	1	https://doi.org/10.1111/j.1471-4159.1990.tb01889.x	https://doi.org/10.1111/j.1471-4159.1990.tb01889.x	PRON
fnp-3459	246	2	svennerholm	svennerholm	PROPN
fnp-3459	246	3	l	l	PROPN
fnp-3459	246	4	,	,	PUNCT
fnp-3459	246	5	bostrom	bostrom	PROPN
fnp-3459	246	6	k	k	PROPN
fnp-3459	246	7	,	,	PUNCT
fnp-3459	246	8	jungbjer	jungbjer	PROPN
fnp-3459	246	9	b	b	PROPN
fnp-3459	246	10	,	,	PUNCT
fnp-3459	246	11	olsson	olsson	PROPN
fnp-3459	246	12	l.	l.	PROPN
fnp-3459	246	13	membrane	membrane	PROPN
fnp-3459	246	14	lipids	lipid	NOUN
fnp-3459	246	15	of	of	ADP
fnp-3459	246	16	adult	adult	NOUN
fnp-3459	246	17	human	human	ADJ
fnp-3459	246	18	brain	brain	NOUN
fnp-3459	246	19	:	:	PUNCT
fnp-3459	246	20	lipid	lipid	NOUN
fnp-3459	246	21	composition	composition	NOUN
fnp-3459	246	22	of	of	ADP
fnp-3459	246	23	frontal	frontal	ADJ
fnp-3459	246	24	and	and	CCONJ
fnp-3459	246	25	temporal	temporal	ADJ
fnp-3459	246	26	lobe	lobe	NOUN
fnp-3459	246	27	in	in	ADP
fnp-3459	246	28	subjects	subject	NOUN
fnp-3459	246	29	of	of	ADP
fnp-3459	246	30	age	age	NOUN
fnp-3459	246	31	20	20	NUM
fnp-3459	246	32	to	to	PART
fnp-3459	246	33	100	100	NUM
fnp-3459	246	34	years	year	NOUN
fnp-3459	246	35	.	.	PUNCT
fnp-3459	247	1	j	j	PROPN
fnp-3459	247	2	neurochem	neurochem	PROPN
fnp-3459	247	3	.	.	PUNCT
fnp-3459	248	1	1994;63(5):1802	1994;63(5):1802	NUM
fnp-3459	248	2	-	-	SYM
fnp-3459	248	3	11	11	NUM
fnp-3459	248	4	.	.	PUNCT
fnp-3459	248	5	https://doi.org/10.1046/j.1471-4159.1994.63051802.x	https://doi.org/10.1046/j.1471-4159.1994.63051802.x	NOUN
fnp-3459	248	6	de	de	PROPN
fnp-3459	248	7	chaves	chaves	PROPN
fnp-3459	248	8	ep	ep	PROPN
fnp-3459	248	9	,	,	PUNCT
fnp-3459	248	10	narayanaswami	narayanaswami	PROPN
fnp-3459	248	11	v.	v.	ADP
fnp-3459	248	12	apolipoprotein	apolipoprotein	ADJ
fnp-3459	248	13	e	e	PROPN
fnp-3459	248	14	and	and	CCONJ
fnp-3459	248	15	cholesterol	cholesterol	NOUN
fnp-3459	248	16	in	in	ADP
fnp-3459	248	17	aging	aging	NOUN
fnp-3459	248	18	and	and	CCONJ
fnp-3459	248	19	disease	disease	NOUN
fnp-3459	248	20	in	in	ADP
fnp-3459	248	21	the	the	DET
fnp-3459	248	22	brain	brain	NOUN
fnp-3459	248	23	.	.	PUNCT
fnp-3459	249	1	future	future	ADJ
fnp-3459	249	2	lipidol	lipidol	NOUN
fnp-3459	249	3	.	.	PUNCT
fnp-3459	250	1	2008;3(5):505	2008;3(5):505	X
fnp-3459	250	2	-	-	SYM
fnp-3459	250	3	30	30	NUM
fnp-3459	250	4	.	.	PUNCT
fnp-3459	251	1	https://doi.org/10.2217/17460875.3.5.505	https://doi.org/10.2217/17460875.3.5.505	PROPN
fnp-3459	251	2	welander	welander	PROPN
fnp-3459	251	3	h	h	PROPN
fnp-3459	251	4	,	,	PUNCT
fnp-3459	251	5	frånberg	frånberg	PROPN
fnp-3459	251	6	j	j	PROPN
fnp-3459	251	7	,	,	PUNCT
fnp-3459	251	8	graff	graff	VERB
fnp-3459	251	9	c	c	NOUN
fnp-3459	251	10	,	,	PUNCT
fnp-3459	251	11	sundström	sundström	PROPN
fnp-3459	251	12	e	e	NOUN
fnp-3459	251	13	,	,	PUNCT
fnp-3459	251	14	winblad	winblad	PROPN
fnp-3459	251	15	b	b	NUM
fnp-3459	251	16	,	,	PUNCT
fnp-3459	251	17	tjernberg	tjernberg	PROPN
fnp-3459	251	18	lo	lo	PROPN
fnp-3459	251	19	.	.	PROPN
fnp-3459	251	20	abeta43	abeta43	PROPN
fnp-3459	251	21	is	be	AUX
fnp-3459	251	22	more	more	ADV
fnp-3459	251	23	frequent	frequent	ADJ
fnp-3459	251	24	than	than	ADP
fnp-3459	251	25	abeta40	abeta40	NOUN
fnp-3459	251	26	in	in	ADP
fnp-3459	251	27	amyloid	amyloid	NOUN
fnp-3459	251	28	plaque	plaque	NOUN
fnp-3459	251	29	cores	core	NOUN
fnp-3459	251	30	from	from	ADP
fnp-3459	251	31	alzheimer	alzheimer	PROPN
fnp-3459	251	32	disease	disease	NOUN
fnp-3459	251	33	brains	brain	NOUN
fnp-3459	251	34	.	.	PUNCT
fnp-3459	252	1	j	j	PROPN
fnp-3459	252	2	neurochem	neurochem	PROPN
fnp-3459	252	3	.	.	PUNCT
fnp-3459	253	1	2009;110(2):697	2009;110(2):697	NUM
fnp-3459	253	2	-	-	SYM
fnp-3459	253	3	706	706	NUM
fnp-3459	253	4	.	.	PUNCT
fnp-3459	254	1	https://doi.org/10.1111/j.1471-4159.2009.06170.x	https://doi.org/10.1111/j.1471-4159.2009.06170.x	PROPN
fnp-3459	254	2	saito	saito	PROPN
fnp-3459	254	3	t	t	PROPN
fnp-3459	254	4	,	,	PUNCT
fnp-3459	254	5	suemoto	suemoto	NOUN
fnp-3459	254	6	t	t	PROPN
fnp-3459	254	7	,	,	PUNCT
fnp-3459	254	8	brouwers	brouwer	NOUN
fnp-3459	254	9	n	n	CCONJ
fnp-3459	254	10	,	,	PUNCT
fnp-3459	254	11	sleegers	sleeger	NOUN
fnp-3459	254	12	k	k	PROPN
fnp-3459	254	13	,	,	PUNCT
fnp-3459	254	14	funamoto	funamoto	PROPN
fnp-3459	254	15	s	s	PROPN
fnp-3459	254	16	,	,	PUNCT
fnp-3459	254	17	mihira	mihira	PROPN
fnp-3459	254	18	n	n	CCONJ
fnp-3459	254	19	,	,	PUNCT
fnp-3459	254	20	et	et	PROPN
fnp-3459	254	21	al	al	PROPN
fnp-3459	254	22	.	.	PROPN
fnp-3459	255	1	potent	potent	ADJ
fnp-3459	255	2	amyloidogenicity	amyloidogenicity	NOUN
fnp-3459	255	3	and	and	CCONJ
fnp-3459	255	4	pathogenicity	pathogenicity	NOUN
fnp-3459	255	5	of	of	ADP
fnp-3459	255	6	abeta43	abeta43	NOUN
fnp-3459	255	7	.	.	PUNCT
fnp-3459	256	1	nat	nat	PROPN
fnp-3459	256	2	neurosci	neurosci	PROPN
fnp-3459	256	3	.	.	PUNCT
fnp-3459	257	1	2011;14(8):1023	2011;14(8):1023	NUM
fnp-3459	257	2	-	-	SYM
fnp-3459	257	3	32	32	NUM
fnp-3459	257	4	.	.	PUNCT
fnp-3459	258	1	https://doi.org/10.1038/nn.2858	https://doi.org/10.1038/nn.2858	PRON
fnp-3459	258	2	grimm	grimm	PROPN
fnp-3459	258	3	mo	mo	PROPN
fnp-3459	258	4	,	,	PUNCT
fnp-3459	258	5	grimm	grimm	PROPN
fnp-3459	258	6	hs	hs	PROPN
fnp-3459	258	7	,	,	PUNCT
fnp-3459	258	8	hartmann	hartmann	PROPN
fnp-3459	258	9	t.	t.	PROPN
fnp-3459	258	10	amyloid	amyloid	PROPN
fnp-3459	258	11	beta	beta	NOUN
fnp-3459	258	12	as	as	ADP
fnp-3459	258	13	a	a	DET
fnp-3459	258	14	regulator	regulator	NOUN
fnp-3459	258	15	of	of	ADP
fnp-3459	258	16	lipid	lipid	ADJ
fnp-3459	258	17	homeostasis	homeostasis	NOUN
fnp-3459	258	18	.	.	PUNCT
fnp-3459	259	1	trends	trend	NOUN
fnp-3459	259	2	mol	mol	ADP
fnp-3459	259	3	med	med	PROPN
fnp-3459	259	4	.	.	PUNCT
fnp-3459	260	1	2007;13(8):337	2007;13(8):337	NUM
fnp-3459	260	2	-	-	SYM
fnp-3459	260	3	44	44	NUM
fnp-3459	260	4	.	.	PUNCT
fnp-3459	261	1	https://doi.org/10.1016/j.molmed.2007.06.004	https://doi.org/10.1016/j.molmed.2007.06.004	NUM
fnp-3459	261	2	grimm	grimm	PROPN
fnp-3459	261	3	mo	mo	PROPN
fnp-3459	261	4	,	,	PUNCT
fnp-3459	261	5	grimm	grimm	PROPN
fnp-3459	261	6	hs	hs	PROPN
fnp-3459	261	7	,	,	PUNCT
fnp-3459	261	8	patzold	patzold	PROPN
fnp-3459	261	9	aj	aj	PROPN
fnp-3459	261	10	,	,	PUNCT
fnp-3459	261	11	zinser	zinser	PROPN
fnp-3459	261	12	eg	eg	PROPN
fnp-3459	261	13	,	,	PUNCT
fnp-3459	261	14	halonen	halonen	NOUN
fnp-3459	261	15	r	r	NOUN
fnp-3459	261	16	,	,	PUNCT
fnp-3459	261	17	duering	duere	VERB
fnp-3459	261	18	m	m	PRON
fnp-3459	261	19	,	,	PUNCT
fnp-3459	261	20	et	et	PROPN
fnp-3459	261	21	al	al	PROPN
fnp-3459	261	22	.	.	PUNCT
fnp-3459	261	23	regulation	regulation	NOUN
fnp-3459	261	24	of	of	ADP
fnp-3459	261	25	cholesterol	cholesterol	NOUN
fnp-3459	261	26	and	and	CCONJ
fnp-3459	261	27	sphingomyelin	sphingomyelin	NOUN
fnp-3459	261	28	metabolism	metabolism	NOUN
fnp-3459	261	29	by	by	ADP
fnp-3459	261	30	amyloid	amyloid	NOUN
fnp-3459	261	31	-	-	PUNCT
fnp-3459	261	32	beta	beta	NOUN
fnp-3459	261	33	and	and	CCONJ
fnp-3459	261	34	presenilin	presenilin	PROPN
fnp-3459	261	35	.	.	PUNCT
fnp-3459	262	1	nat	nat	PROPN
fnp-3459	262	2	cell	cell	NOUN
fnp-3459	262	3	biol	biol	PROPN
fnp-3459	262	4	.	.	PUNCT
fnp-3459	263	1	2005;7(11):1118	2005;7(11):1118	NUM
fnp-3459	263	2	-	-	SYM
fnp-3459	263	3	23	23	NUM
fnp-3459	263	4	.	.	PUNCT
fnp-3459	264	1	https://doi.org/10.1038/ncb1313	https://doi.org/10.1038/ncb1313	VERB
fnp-3459	264	2	tachibana	tachibana	PROPN
fnp-3459	264	3	m	m	PROPN
fnp-3459	264	4	,	,	PUNCT
fnp-3459	264	5	holm	holm	PROPN
fnp-3459	264	6	ml	ml	PROPN
fnp-3459	264	7	,	,	PUNCT
fnp-3459	264	8	liu	liu	PROPN
fnp-3459	264	9	cc	cc	PROPN
fnp-3459	264	10	,	,	PUNCT
fnp-3459	264	11	shinohara	shinohara	PROPN
fnp-3459	264	12	m	m	PROPN
fnp-3459	264	13	,	,	PUNCT
fnp-3459	264	14	aikawa	aikawa	PROPN
fnp-3459	264	15	t	t	PROPN
fnp-3459	264	16	,	,	PUNCT
fnp-3459	264	17	oue	oue	PROPN
fnp-3459	264	18	h	h	PROPN
fnp-3459	264	19	,	,	PUNCT
fnp-3459	264	20	et	et	PROPN
fnp-3459	264	21	al	al	PROPN
fnp-3459	264	22	.	.	PUNCT
fnp-3459	265	1	apoe4	apoe4	PROPN
fnp-3459	265	2	-	-	PUNCT
fnp-3459	265	3	mediated	mediate	VERB
fnp-3459	265	4	amyloid	amyloid	NOUN
fnp-3459	265	5	-	-	PUNCT
fnp-3459	265	6	beta	beta	NOUN
fnp-3459	265	7	pathology	pathology	NOUN
fnp-3459	265	8	depends	depend	VERB
fnp-3459	265	9	on	on	ADP
fnp-3459	265	10	its	its	PRON
fnp-3459	265	11	neuronal	neuronal	ADJ
fnp-3459	265	12	receptor	receptor	NOUN
fnp-3459	265	13	lrp1	lrp1	NOUN
fnp-3459	265	14	.	.	PUNCT
fnp-3459	266	1	j	j	PROPN
fnp-3459	266	2	clin	clin	PROPN
fnp-3459	266	3	invest	invest	PROPN
fnp-3459	266	4	.	.	PUNCT
fnp-3459	267	1	2019;129(3):1272	2019;129(3):1272	NUM
fnp-3459	267	2	-	-	SYM
fnp-3459	267	3	7	7	NUM
fnp-3459	267	4	.	.	PUNCT
fnp-3459	267	5	https://doi.org/10.1172/jci124853	https://doi.org/10.1172/jci124853	NOUN
fnp-3459	267	6	dumas	dumas	PROPN
fnp-3459	267	7	a	a	PRON
fnp-3459	267	8	,	,	PUNCT
fnp-3459	267	9	dierksen	dierksen	PROPN
fnp-3459	267	10	ga	ga	PROPN
fnp-3459	267	11	,	,	PUNCT
fnp-3459	267	12	gurol	gurol	VERB
fnp-3459	267	13	me	i	PRON
fnp-3459	267	14	,	,	PUNCT
fnp-3459	267	15	halpin	halpin	PROPN
fnp-3459	267	16	a	a	PROPN
fnp-3459	267	17	,	,	PUNCT
fnp-3459	267	18	martinez	martinez	PROPN
fnp-3459	267	19	-	-	PROPN
fnp-3459	267	20	ramirez	ramirez	PROPN
fnp-3459	267	21	s	s	PART
fnp-3459	267	22	,	,	PUNCT
fnp-3459	267	23	schwab	schwab	PROPN
fnp-3459	267	24	k	k	PROPN
fnp-3459	267	25	,	,	PUNCT
fnp-3459	267	26	et	et	PROPN
fnp-3459	267	27	al	al	PROPN
fnp-3459	267	28	.	.	PROPN
fnp-3459	268	1	functional	functional	ADJ
fnp-3459	268	2	magnetic	magnetic	ADJ
fnp-3459	268	3	resonance	resonance	NOUN
fnp-3459	268	4	imaging	imaging	NOUN
fnp-3459	268	5	detection	detection	NOUN
fnp-3459	268	6	of	of	ADP
fnp-3459	268	7	vascular	vascular	ADJ
fnp-3459	268	8	reactivity	reactivity	NOUN
fnp-3459	268	9	in	in	ADP
fnp-3459	268	10	cerebral	cerebral	ADJ
fnp-3459	268	11	amyloid	amyloid	NOUN
fnp-3459	268	12	angiopathy	angiopathy	NOUN
fnp-3459	268	13	.	.	PUNCT
fnp-3459	269	1	ann	ann	PROPN
fnp-3459	269	2	neurol	neurol	PROPN
fnp-3459	269	3	.	.	PUNCT
fnp-3459	270	1	2012;72(1):76	2012;72(1):76	NUM
fnp-3459	270	2	-	-	SYM
fnp-3459	270	3	81	81	NUM
fnp-3459	270	4	.	.	PUNCT
fnp-3459	271	1	https://doi.org/10.1002/ana.23566	https://doi.org/10.1002/ana.23566	PROPN
fnp-3459	271	2	frank	frank	PROPN
fnp-3459	271	3	c	c	PROPN
fnp-3459	271	4	,	,	PUNCT
fnp-3459	271	5	rufini	rufini	PROPN
fnp-3459	271	6	s	s	PROPN
fnp-3459	271	7	,	,	PUNCT
fnp-3459	271	8	tancredi	tancredi	NOUN
fnp-3459	271	9	v	v	NOUN
fnp-3459	271	10	,	,	PUNCT
fnp-3459	271	11	forcina	forcina	VERB
fnp-3459	271	12	r	r	NOUN
fnp-3459	271	13	,	,	PUNCT
fnp-3459	271	14	grossi	grossi	PROPN
fnp-3459	271	15	d	d	NOUN
fnp-3459	271	16	,	,	PUNCT
fnp-3459	271	17	d'arcangelo	d'arcangelo	PRON
fnp-3459	271	18	g.	g.	PROPN
fnp-3459	271	19	cholesterol	cholesterol	NOUN
fnp-3459	271	20	depletion	depletion	NOUN
fnp-3459	271	21	inhibits	inhibit	VERB
fnp-3459	271	22	synaptic	synaptic	ADJ
fnp-3459	271	23	transmission	transmission	NOUN
fnp-3459	271	24	and	and	CCONJ
fnp-3459	271	25	synaptic	synaptic	ADJ
fnp-3459	271	26	plasticity	plasticity	NOUN
fnp-3459	271	27	in	in	ADP
fnp-3459	271	28	rat	rat	NOUN
fnp-3459	271	29	hippocampus	hippocampus	NOUN
fnp-3459	271	30	.	.	PUNCT
fnp-3459	272	1	exp	exp	NOUN
fnp-3459	272	2	neurol	neurol	NOUN
fnp-3459	272	3	.	.	PUNCT
fnp-3459	273	1	2008;212(2):407	2008;212(2):407	NUM
fnp-3459	273	2	-	-	SYM
fnp-3459	273	3	14	14	NUM
fnp-3459	273	4	.	.	PUNCT
fnp-3459	274	1	https://doi.org/10.1016/j.expneurol.2008.04.019	https://doi.org/10.1016/j.expneurol.2008.04.019	NUM
fnp-3459	274	2	maggo	maggo	NOUN
fnp-3459	274	3	s	s	PROPN
fnp-3459	274	4	,	,	PUNCT
fnp-3459	274	5	ashton	ashton	PROPN
fnp-3459	274	6	jc	jc	PROPN
fnp-3459	274	7	.	.	PUNCT
fnp-3459	275	1	effects	effect	NOUN
fnp-3459	275	2	of	of	ADP
fnp-3459	275	3	hmg	hmg	NOUN
fnp-3459	275	4	-	-	PUNCT
fnp-3459	275	5	coa	coa	NOUN
fnp-3459	275	6	reductase	reductase	NOUN
fnp-3459	275	7	inhibitors	inhibitor	NOUN
fnp-3459	275	8	on	on	ADP
fnp-3459	275	9	learning	learning	NOUN
fnp-3459	275	10	and	and	CCONJ
fnp-3459	275	11	memory	memory	NOUN
fnp-3459	275	12	in	in	ADP
fnp-3459	275	13	the	the	DET
fnp-3459	275	14	guinea	guinea	NOUN
fnp-3459	275	15	pig	pig	NOUN
fnp-3459	275	16	.	.	PUNCT
fnp-3459	276	1	european	european	PROPN
fnp-3459	276	2	journal	journal	PROPN
fnp-3459	276	3	of	of	ADP
fnp-3459	276	4	pharmacology	pharmacology	NOUN
fnp-3459	276	5	.	.	PUNCT
fnp-3459	277	1	2014;723:294	2014;723:294	NUM
fnp-3459	277	2	-	-	SYM
fnp-3459	277	3	304	304	NUM
fnp-3459	277	4	.	.	PUNCT
fnp-3459	278	1	https://doi.org/10.1016/j.ejphar.2013.11.018	https://doi.org/10.1016/j.ejphar.2013.11.018	NOUN
fnp-3459	278	2	korinek	korinek	ADJ
fnp-3459	278	3	m	m	PROPN
fnp-3459	278	4	,	,	PUNCT
fnp-3459	278	5	gonzalez	gonzalez	PROPN
fnp-3459	278	6	-	-	PUNCT
fnp-3459	278	7	gonzalez	gonzalez	PROPN
fnp-3459	279	1	i	i	PRON
fnp-3459	279	2	m	m	PROPN
fnp-3459	279	3	,	,	PUNCT
fnp-3459	279	4	smejkalova	smejkalova	PROPN
fnp-3459	279	5	t	t	PROPN
fnp-3459	279	6	,	,	PUNCT
fnp-3459	279	7	hajdukovic	hajdukovic	PROPN
fnp-3459	279	8	d	d	PROPN
fnp-3459	279	9	,	,	PUNCT
fnp-3459	279	10	skrenkova	skrenkova	X
fnp-3459	279	11	k	k	X
fnp-3459	279	12	,	,	PUNCT
fnp-3459	279	13	krusek	krusek	PROPN
fnp-3459	279	14	j	j	PROPN
fnp-3459	279	15	,	,	PUNCT
fnp-3459	279	16	et	et	PROPN
fnp-3459	279	17	al	al	PROPN
fnp-3459	279	18	.	.	PUNCT
fnp-3459	280	1	cholesterol	cholesterol	NOUN
fnp-3459	280	2	modulates	modulate	NOUN
fnp-3459	280	3	presynaptic	presynaptic	ADJ
fnp-3459	280	4	and	and	CCONJ
fnp-3459	280	5	postsynaptic	postsynaptic	ADJ
fnp-3459	280	6	properties	property	NOUN
fnp-3459	280	7	of	of	ADP
fnp-3459	280	8	excitatory	excitatory	ADJ
fnp-3459	280	9	synaptic	synaptic	ADJ
fnp-3459	280	10	transmission	transmission	NOUN
fnp-3459	280	11	.	.	PUNCT
fnp-3459	281	1	scientific	scientific	ADJ
fnp-3459	281	2	reports	report	NOUN
fnp-3459	281	3	.	.	PUNCT
fnp-3459	282	1	2020;10(1):12651	2020;10(1):12651	X
fnp-3459	282	2	.	.	PUNCT
fnp-3459	282	3	https://doi.org/10.1038/s41598-020-69454-5	https://doi.org/10.1038/s41598-020-69454-5	VERB
fnp-3459	282	4	yujun	yujun	PROPN
fnp-3459	282	5	g	g	PROPN
fnp-3459	282	6	,	,	PUNCT
fnp-3459	282	7	guichang	guichang	PROPN
fnp-3459	282	8	z	z	PROPN
fnp-3459	282	9	,	,	PUNCT
fnp-3459	282	10	jin	jin	PROPN
fnp-3459	282	11	j	j	PROPN
fnp-3459	282	12	,	,	PUNCT
fnp-3459	282	13	lei	lei	PROPN
fnp-3459	282	14	y	y	PROPN
fnp-3459	282	15	,	,	PUNCT
fnp-3459	282	16	keke	keke	PROPN
fnp-3459	282	17	q	q	PROPN
fnp-3459	282	18	,	,	PUNCT
fnp-3459	282	19	yang	yang	PROPN
fnp-3459	282	20	p	p	PROPN
fnp-3459	282	21	,	,	PUNCT
fnp-3459	283	1	et	et	PROPN
fnp-3459	283	2	al	al	PROPN
fnp-3459	283	3	.	.	PROPN
fnp-3459	283	4	simvastatin	simvastatin	PROPN
fnp-3459	283	5	impairs	impair	VERB
fnp-3459	283	6	hippocampal	hippocampal	ADJ
fnp-3459	283	7	synaptic	synaptic	ADJ
fnp-3459	283	8	plasticity	plasticity	NOUN
fnp-3459	283	9	and	and	CCONJ
fnp-3459	283	10	cognitive	cognitive	ADJ
fnp-3459	283	11	function	function	NOUN
fnp-3459	283	12	in	in	ADP
fnp-3459	283	13	mice	mouse	NOUN
fnp-3459	283	14	.	.	PUNCT
fnp-3459	284	1	molecular	molecular	ADJ
fnp-3459	284	2	brain	brain	NOUN
fnp-3459	284	3	.	.	PUNCT
fnp-3459	285	1	2020	2020	NUM
fnp-3459	285	2	.	.	PUNCT
fnp-3459	286	1	https://doi.org/10.21203/rs.3.rs-76680/v1	https://doi.org/10.21203/rs.3.rs-76680/v1	PROPN
fnp-3459	286	2	mauch	mauch	PROPN
fnp-3459	286	3	dh	dh	PROPN
fnp-3459	286	4	,	,	PUNCT
fnp-3459	286	5	nagler	nagler	PROPN
fnp-3459	286	6	k	k	PROPN
fnp-3459	286	7	,	,	PUNCT
fnp-3459	286	8	schumacher	schumacher	PROPN
fnp-3459	286	9	s	s	PROPN
fnp-3459	286	10	,	,	PUNCT
fnp-3459	286	11	goritz	goritz	NOUN
fnp-3459	286	12	c	c	PROPN
fnp-3459	286	13	,	,	PUNCT
fnp-3459	286	14	muller	muller	PROPN
fnp-3459	286	15	ec	ec	PROPN
fnp-3459	286	16	,	,	PUNCT
fnp-3459	286	17	otto	otto	PROPN
fnp-3459	286	18	a	a	PROPN
fnp-3459	286	19	,	,	PUNCT
fnp-3459	286	20	et	et	PROPN
fnp-3459	286	21	al	al	PROPN
fnp-3459	286	22	.	.	PUNCT
fnp-3459	286	23	cns	cns	PROPN
fnp-3459	286	24	synaptogenesis	synaptogenesis	NOUN
fnp-3459	286	25	promoted	promote	VERB
fnp-3459	286	26	by	by	ADP
fnp-3459	286	27	glia	glia	NOUN
fnp-3459	286	28	-	-	PUNCT
fnp-3459	286	29	derived	derive	VERB
fnp-3459	286	30	cholesterol	cholesterol	NOUN
fnp-3459	286	31	.	.	PUNCT
fnp-3459	287	1	science	science	NOUN
fnp-3459	287	2	.	.	PUNCT
fnp-3459	288	1	2001;294(5545):1354	2001;294(5545):1354	NUM
fnp-3459	288	2	-	-	SYM
fnp-3459	288	3	7	7	NUM
fnp-3459	288	4	.	.	PUNCT
fnp-3459	289	1	https://doi.org/10.1126/science.294.5545.1354	https://doi.org/10.1126/science.294.5545.1354	NOUN
fnp-3459	289	2	pfrieger	pfrieger	NOUN
fnp-3459	289	3	fw	fw	PROPN
fnp-3459	289	4	.	.	PROPN
fnp-3459	289	5	role	role	NOUN
fnp-3459	289	6	of	of	ADP
fnp-3459	289	7	cholesterol	cholesterol	NOUN
fnp-3459	289	8	in	in	ADP
fnp-3459	289	9	synapse	synapse	NOUN
fnp-3459	289	10	formation	formation	NOUN
fnp-3459	289	11	and	and	CCONJ
fnp-3459	289	12	function	function	NOUN
fnp-3459	289	13	.	.	PUNCT
fnp-3459	290	1	biochim	biochim	PROPN
fnp-3459	290	2	biophys	biophy	NOUN
fnp-3459	290	3	acta	acta	PROPN
fnp-3459	290	4	.	.	PUNCT
fnp-3459	291	1	2003;1610(2):271	2003;1610(2):271	NUM
fnp-3459	291	2	-	-	PUNCT
fnp-3459	291	3	80	80	NUM
fnp-3459	291	4	.	.	PUNCT
fnp-3459	292	1	https://doi.org/10.1016/s0005-2736(03)00024-5	https://doi.org/10.1016/s0005-2736(03)00024-5	PROPN
fnp-3459	292	2	teasdale	teasdale	PROPN
fnp-3459	292	3	gm	gm	PROPN
fnp-3459	292	4	,	,	PUNCT
fnp-3459	292	5	nicoll	nicoll	PROPN
fnp-3459	292	6	ja	ja	PROPN
fnp-3459	292	7	,	,	PUNCT
fnp-3459	292	8	murray	murray	PROPN
fnp-3459	292	9	g	g	PROPN
fnp-3459	292	10	,	,	PUNCT
fnp-3459	292	11	fiddes	fidde	VERB
fnp-3459	292	12	m.	m.	NOUN
fnp-3459	292	13	association	association	NOUN
fnp-3459	292	14	of	of	ADP
fnp-3459	292	15	apolipoprotein	apolipoprotein	ADJ
fnp-3459	292	16	e	e	PROPN
fnp-3459	292	17	polymorphism	polymorphism	NOUN
fnp-3459	292	18	with	with	ADP
fnp-3459	292	19	outcome	outcome	NOUN
fnp-3459	292	20	after	after	ADP
fnp-3459	292	21	head	head	NOUN
fnp-3459	292	22	injury	injury	NOUN
fnp-3459	292	23	.	.	PUNCT
fnp-3459	293	1	lancet	lancet	PROPN
fnp-3459	293	2	.	.	PUNCT
fnp-3459	294	1	1997;350(9084):1069	1997;350(9084):1069	NUM
fnp-3459	294	2	-	-	SYM
fnp-3459	294	3	71	71	NUM
fnp-3459	294	4	.	.	PUNCT
fnp-3459	295	1	https://doi.org/10.1016/s0140-6736(97)04318-3	https://doi.org/10.1016/s0140-6736(97)04318-3	PROPN
fnp-3459	295	2	teasdale	teasdale	PROPN
fnp-3459	295	3	gm	gm	PROPN
fnp-3459	295	4	,	,	PUNCT
fnp-3459	295	5	murray	murray	PROPN
fnp-3459	295	6	gd	gd	PROPN
fnp-3459	295	7	,	,	PUNCT
fnp-3459	295	8	nicoll	nicoll	PROPN
fnp-3459	295	9	ja	ja	PROPN
fnp-3459	295	10	.	.	PUNCT
fnp-3459	296	1	the	the	DET
fnp-3459	296	2	association	association	NOUN
fnp-3459	296	3	between	between	ADP
fnp-3459	296	4	apoe	apoe	PROPN
fnp-3459	296	5	epsilon4	epsilon4	NOUN
fnp-3459	296	6	,	,	PUNCT
fnp-3459	296	7	age	age	NOUN
fnp-3459	296	8	and	and	CCONJ
fnp-3459	296	9	outcome	outcome	NOUN
fnp-3459	296	10	after	after	ADP
fnp-3459	296	11	head	head	NOUN
fnp-3459	296	12	injury	injury	PROPN
fnp-3459	296	13	:	:	PUNCT
fnp-3459	296	14	a	a	DET
fnp-3459	296	15	prospective	prospective	ADJ
fnp-3459	296	16	cohort	cohort	NOUN
fnp-3459	296	17	study	study	NOUN
fnp-3459	296	18	.	.	PUNCT
fnp-3459	297	1	brain	brain	NOUN
fnp-3459	297	2	.	.	PUNCT
fnp-3459	298	1	2005;128(pt	2005;128(pt	PROPN
fnp-3459	298	2	11):2556	11):2556	NUM
fnp-3459	298	3	-	-	SYM
fnp-3459	298	4	61	61	NUM
fnp-3459	298	5	.	.	PUNCT
fnp-3459	299	1	https://doi.org/10.1093/brain/awh595	https://doi.org/10.1093/brain/awh595	ADJ
fnp-3459	299	2	deng	deng	PROPN
fnp-3459	299	3	h	h	PROPN
fnp-3459	299	4	,	,	PUNCT
fnp-3459	299	5	ordaz	ordaz	VERB
fnp-3459	299	6	a	a	PRON
fnp-3459	299	7	,	,	PUNCT
fnp-3459	299	8	upadhyayula	upadhyayula	PROPN
fnp-3459	299	9	ps	ps	PROPN
fnp-3459	299	10	,	,	PUNCT
fnp-3459	299	11	gillis	gillis	PROPN
fnp-3459	299	12	-	-	PUNCT
fnp-3459	299	13	buck	buck	PROPN
fnp-3459	299	14	em	em	PRON
fnp-3459	299	15	,	,	PUNCT
fnp-3459	299	16	suen	suen	PROPN
fnp-3459	299	17	cg	cg	PROPN
fnp-3459	299	18	,	,	PUNCT
fnp-3459	299	19	melhado	melhado	PROPN
fnp-3459	299	20	cg	cg	PROPN
fnp-3459	299	21	,	,	PUNCT
fnp-3459	299	22	et	et	PROPN
fnp-3459	299	23	al	al	PROPN
fnp-3459	299	24	.	.	PROPN
fnp-3459	300	1	apolipoprotein	apolipoprotein	PROPN
fnp-3459	300	2	e	e	PROPN
fnp-3459	300	3	epsilon	epsilon	PROPN
fnp-3459	300	4	4	4	NUM
fnp-3459	300	5	genotype	genotype	NOUN
fnp-3459	300	6	,	,	PUNCT
fnp-3459	300	7	mild	mild	ADJ
fnp-3459	300	8	traumatic	traumatic	ADJ
fnp-3459	300	9	brain	brain	NOUN
fnp-3459	300	10	injury	injury	NOUN
fnp-3459	300	11	,	,	PUNCT
fnp-3459	300	12	and	and	CCONJ
fnp-3459	300	13	the	the	DET
fnp-3459	300	14	development	development	NOUN
fnp-3459	300	15	of	of	ADP
fnp-3459	300	16	chronic	chronic	ADJ
fnp-3459	300	17	traumatic	traumatic	ADJ
fnp-3459	300	18	encephalopathy	encephalopathy	NOUN
fnp-3459	300	19	.	.	PUNCT
fnp-3459	301	1	med	med	PROPN
fnp-3459	301	2	sci	sci	PROPN
fnp-3459	301	3	(	(	PUNCT
fnp-3459	301	4	basel	basel	PROPN
fnp-3459	301	5	)	)	PUNCT
fnp-3459	301	6	.	.	PUNCT
fnp-3459	302	1	2018;6(3):78	2018;6(3):78	X
fnp-3459	302	2	.	.	PUNCT
fnp-3459	303	1	https://doi.org/10.3390/medsci6030078	https://doi.org/10.3390/medsci6030078	PROPN
fnp-3459	303	2	poirier	poirier	PROPN
fnp-3459	303	3	j.	j.	PROPN
fnp-3459	303	4	apolipoprotein	apolipoprotein	PROPN
fnp-3459	303	5	e	e	PROPN
fnp-3459	303	6	in	in	ADP
fnp-3459	303	7	animal	animal	NOUN
fnp-3459	303	8	models	model	NOUN
fnp-3459	303	9	of	of	ADP
fnp-3459	303	10	cns	cns	NOUN
fnp-3459	303	11	injury	injury	NOUN
fnp-3459	303	12	and	and	CCONJ
fnp-3459	303	13	in	in	ADP
fnp-3459	303	14	alzheimer	alzheimer	PROPN
fnp-3459	303	15	's	's	PART
fnp-3459	303	16	disease	disease	NOUN
fnp-3459	303	17	.	.	PUNCT
fnp-3459	304	1	trends	trend	NOUN
fnp-3459	304	2	neurosci	neurosci	PROPN
fnp-3459	304	3	.	.	PUNCT
fnp-3459	305	1	1994;17(12):525	1994;17(12):525	PROPN
fnp-3459	305	2	-	-	PUNCT
fnp-3459	305	3	30	30	NUM
fnp-3459	305	4	.	.	PUNCT
fnp-3459	306	1	https://doi.org/10.1016/0166-2236(94)90156-2	https://doi.org/10.1016/0166-2236(94)90156-2	PROPN
fnp-3459	306	2	sabo	sabo	PROPN
fnp-3459	306	3	t	t	PROPN
fnp-3459	306	4	,	,	PUNCT
fnp-3459	306	5	lomnitski	lomnitski	ADJ
fnp-3459	306	6	l	l	PROPN
fnp-3459	306	7	,	,	PUNCT
fnp-3459	306	8	nyska	nyska	VERB
fnp-3459	306	9	a	a	X
fnp-3459	306	10	,	,	PUNCT
fnp-3459	306	11	beni	beni	PROPN
fnp-3459	306	12	s	s	PROPN
fnp-3459	306	13	,	,	PUNCT
fnp-3459	306	14	maronpot	maronpot	PROPN
fnp-3459	306	15	rr	rr	PROPN
fnp-3459	306	16	,	,	PUNCT
fnp-3459	306	17	shohami	shohami	NOUN
fnp-3459	306	18	e	e	PROPN
fnp-3459	306	19	,	,	PUNCT
fnp-3459	306	20	et	et	PROPN
fnp-3459	306	21	al	al	PROPN
fnp-3459	306	22	.	.	PROPN
fnp-3459	307	1	susceptibility	susceptibility	NOUN
fnp-3459	307	2	of	of	ADP
fnp-3459	307	3	transgenic	transgenic	NOUN
fnp-3459	307	4	mice	mouse	NOUN
fnp-3459	307	5	expressing	express	VERB
fnp-3459	307	6	human	human	ADJ
fnp-3459	307	7	apolipoprotein	apolipoprotein	ADJ
fnp-3459	307	8	e	e	NOUN
fnp-3459	307	9	to	to	PART
fnp-3459	307	10	closed	close	VERB
fnp-3459	307	11	head	head	NOUN
fnp-3459	307	12	injury	injury	NOUN
fnp-3459	307	13	:	:	PUNCT
fnp-3459	307	14	the	the	DET
fnp-3459	307	15	allele	allele	NOUN
fnp-3459	307	16	e3	e3	NOUN
fnp-3459	307	17	is	be	AUX
fnp-3459	307	18	neuroprotective	neuroprotective	ADJ
fnp-3459	307	19	whereas	whereas	SCONJ
fnp-3459	307	20	e4	e4	PROPN
fnp-3459	307	21	increases	increase	VERB
fnp-3459	307	22	fatalities	fatality	NOUN
fnp-3459	307	23	.	.	PUNCT
fnp-3459	308	1	neuroscience	neuroscience	NOUN
fnp-3459	308	2	.	.	PUNCT
fnp-3459	309	1	2000;101(4):879	2000;101(4):879	NUM
fnp-3459	309	2	-	-	SYM
fnp-3459	309	3	84	84	NUM
fnp-3459	309	4	.	.	PUNCT
fnp-3459	310	1	https://doi.org/10.1016/s0306-4522(00)00438-3	https://doi.org/10.1016/s0306-4522(00)00438-3	ADJ
fnp-3459	310	2	white	white	PROPN
fnp-3459	310	3	f	f	PROPN
fnp-3459	310	4	,	,	PUNCT
fnp-3459	310	5	nicoll	nicoll	PROPN
fnp-3459	310	6	ja	ja	PROPN
fnp-3459	310	7	,	,	PUNCT
fnp-3459	310	8	roses	rose	NOUN
fnp-3459	310	9	ad	ad	NOUN
fnp-3459	310	10	,	,	PUNCT
fnp-3459	310	11	horsburgh	horsburgh	PROPN
fnp-3459	310	12	k.	k.	PROPN
fnp-3459	310	13	impaired	impair	VERB
fnp-3459	310	14	neuronal	neuronal	ADJ
fnp-3459	310	15	plasticity	plasticity	NOUN
fnp-3459	310	16	in	in	ADP
fnp-3459	310	17	transgenic	transgenic	NOUN
fnp-3459	310	18	mice	mouse	NOUN
fnp-3459	310	19	expressing	express	VERB
fnp-3459	310	20	human	human	ADJ
fnp-3459	310	21	apolipoprotein	apolipoprotein	ADJ
fnp-3459	310	22	e4	e4	PROPN
fnp-3459	310	23	compared	compare	VERB
fnp-3459	310	24	to	to	ADP
fnp-3459	310	25	e3	e3	VERB
fnp-3459	310	26	in	in	ADP
fnp-3459	310	27	a	a	DET
fnp-3459	310	28	model	model	NOUN
fnp-3459	310	29	of	of	ADP
fnp-3459	310	30	entorhinal	entorhinal	ADJ
fnp-3459	310	31	cortex	cortex	NOUN
fnp-3459	310	32	lesion	lesion	NOUN
fnp-3459	310	33	.	.	PUNCT
fnp-3459	311	1	neurobiol	neurobiol	PROPN
fnp-3459	312	1	dis	dis	PROPN
fnp-3459	312	2	.	.	PUNCT
fnp-3459	313	1	2001;8(4):611	2001;8(4):611	NUM
fnp-3459	313	2	-	-	SYM
fnp-3459	313	3	25	25	NUM
fnp-3459	313	4	.	.	PUNCT
fnp-3459	314	1	https://doi.org/10.1006/nbdi.2001.0401	https://doi.org/10.1006/nbdi.2001.0401	PROPN
fnp-3459	314	2	mannix	mannix	PROPN
fnp-3459	314	3	rc	rc	PROPN
fnp-3459	314	4	,	,	PUNCT
fnp-3459	314	5	zhang	zhang	PROPN
fnp-3459	314	6	j	j	PROPN
fnp-3459	314	7	,	,	PUNCT
fnp-3459	314	8	park	park	PROPN
fnp-3459	314	9	j	j	PROPN
fnp-3459	314	10	,	,	PUNCT
fnp-3459	314	11	zhang	zhang	PROPN
fnp-3459	314	12	x	x	PROPN
fnp-3459	314	13	,	,	PUNCT
fnp-3459	314	14	bilal	bilal	PROPN
fnp-3459	314	15	k	k	PROPN
fnp-3459	314	16	,	,	PUNCT
fnp-3459	314	17	walker	walker	PROPN
fnp-3459	314	18	k	k	PROPN
fnp-3459	314	19	,	,	PUNCT
fnp-3459	314	20	et	et	PROPN
fnp-3459	314	21	al	al	PROPN
fnp-3459	314	22	.	.	PUNCT
fnp-3459	315	1	age	age	NOUN
fnp-3459	315	2	-	-	PUNCT
fnp-3459	315	3	dependent	dependent	ADJ
fnp-3459	315	4	effect	effect	NOUN
fnp-3459	315	5	of	of	ADP
fnp-3459	315	6	apolipoprotein	apolipoprotein	ADJ
fnp-3459	315	7	e4	e4	PROPN
fnp-3459	315	8	on	on	ADP
fnp-3459	315	9	functional	functional	ADJ
fnp-3459	315	10	outcome	outcome	NOUN
fnp-3459	315	11	after	after	ADP
fnp-3459	315	12	controlled	control	VERB
fnp-3459	315	13	cortical	cortical	ADJ
fnp-3459	315	14	impact	impact	NOUN
fnp-3459	315	15	in	in	ADP
fnp-3459	315	16	mice	mouse	NOUN
fnp-3459	315	17	.	.	PUNCT
fnp-3459	316	1	j	j	PROPN
fnp-3459	316	2	cereb	cereb	PROPN
fnp-3459	316	3	blood	blood	NOUN
fnp-3459	316	4	flow	flow	NOUN
fnp-3459	316	5	metab	metab	NOUN
fnp-3459	316	6	.	.	PUNCT
fnp-3459	317	1	2011;31(1):351	2011;31(1):351	NUM
fnp-3459	317	2	-	-	SYM
fnp-3459	317	3	61	61	NUM
fnp-3459	317	4	.	.	PUNCT
fnp-3459	318	1	https://doi.org/10.1038/jcbfm.2010.99	https://doi.org/10.1038/jcbfm.2010.99	PROPN
fnp-3459	318	2	tensaouti	tensaouti	PROPN
fnp-3459	318	3	y	y	PROPN
fnp-3459	318	4	,	,	PUNCT
fnp-3459	318	5	yu	yu	PROPN
fnp-3459	318	6	t	t	PROPN
fnp-3459	318	7	-	-	PUNCT
fnp-3459	318	8	s	s	PROPN
fnp-3459	318	9	,	,	PUNCT
fnp-3459	318	10	kernie	kernie	PROPN
fnp-3459	318	11	sg	sg	PROPN
fnp-3459	318	12	.	.	PUNCT
fnp-3459	319	1	apolipoprotein	apolipoprotein	PROPN
fnp-3459	319	2	e	e	PROPN
fnp-3459	319	3	regulates	regulate	VERB
fnp-3459	319	4	the	the	DET
fnp-3459	319	5	maturation	maturation	NOUN
fnp-3459	319	6	of	of	ADP
fnp-3459	319	7	injury	injury	NOUN
fnp-3459	319	8	-	-	PUNCT
fnp-3459	319	9	induced	induce	VERB
fnp-3459	319	10	adult	adult	NOUN
fnp-3459	319	11	-	-	PUNCT
fnp-3459	319	12	born	bear	VERB
fnp-3459	319	13	hippocampal	hippocampal	ADJ
fnp-3459	319	14	neurons	neuron	NOUN
fnp-3459	319	15	following	follow	VERB
fnp-3459	319	16	traumatic	traumatic	ADJ
fnp-3459	319	17	brain	brain	NOUN
fnp-3459	319	18	injury	injury	NOUN
fnp-3459	319	19	.	.	PUNCT
fnp-3459	320	1	plos	plos	PROPN
fnp-3459	320	2	one	one	NUM
fnp-3459	320	3	.	.	PUNCT
fnp-3459	321	1	2020;15(3):e0229240	2020;15(3):e0229240	NUM
fnp-3459	321	2	.	.	PUNCT
fnp-3459	322	1	https://doi.org/10.1371/journal.pone.0229240	https://doi.org/10.1371/journal.pone.0229240	PROPN
fnp-3459	322	2	horsburgh	horsburgh	PROPN
fnp-3459	322	3	k	k	PROPN
fnp-3459	322	4	,	,	PUNCT
fnp-3459	322	5	mcculloch	mcculloch	PROPN
fnp-3459	322	6	j	j	PROPN
fnp-3459	322	7	,	,	PUNCT
fnp-3459	322	8	nilsen	nilsen	PROPN
fnp-3459	322	9	m	m	PROPN
fnp-3459	322	10	,	,	PUNCT
fnp-3459	322	11	mccracken	mccracken	PROPN
fnp-3459	322	12	e	e	PROPN
fnp-3459	322	13	,	,	PUNCT
fnp-3459	322	14	large	large	ADJ
fnp-3459	322	15	c	c	NOUN
fnp-3459	322	16	,	,	PUNCT
fnp-3459	322	17	roses	rose	NOUN
fnp-3459	322	18	ad	ad	NOUN
fnp-3459	322	19	,	,	PUNCT
fnp-3459	322	20	et	et	PROPN
fnp-3459	322	21	al	al	PROPN
fnp-3459	322	22	.	.	PUNCT
fnp-3459	323	1	intraventricular	intraventricular	ADJ
fnp-3459	323	2	infusion	infusion	NOUN
fnp-3459	323	3	of	of	ADP
fnp-3459	323	4	apolipoprotein	apolipoprotein	ADJ
fnp-3459	323	5	e	e	NOUN
fnp-3459	323	6	ameliorates	ameliorate	VERB
fnp-3459	323	7	acute	acute	ADJ
fnp-3459	323	8	neuronal	neuronal	ADJ
fnp-3459	323	9	damage	damage	NOUN
fnp-3459	323	10	after	after	ADP
fnp-3459	323	11	global	global	ADJ
fnp-3459	323	12	cerebral	cerebral	ADJ
fnp-3459	323	13	ischemia	ischemia	NOUN
fnp-3459	323	14	in	in	ADP
fnp-3459	323	15	mice	mouse	NOUN
fnp-3459	323	16	.	.	PUNCT
fnp-3459	324	1	j	j	PROPN
fnp-3459	324	2	cereb	cereb	PROPN
fnp-3459	324	3	blood	blood	NOUN
fnp-3459	324	4	flow	flow	NOUN
fnp-3459	324	5	metab	metab	NOUN
fnp-3459	324	6	.	.	PUNCT
fnp-3459	325	1	2000;20(3):458	2000;20(3):458	NUM
fnp-3459	325	2	-	-	SYM
fnp-3459	325	3	62	62	NUM
fnp-3459	325	4	.	.	PUNCT
fnp-3459	326	1	https://doi.org/10.1097/00004647-200003000-00003	https://doi.org/10.1097/00004647-200003000-00003	PRON
fnp-3459	326	2	báez	báez	NOUN
fnp-3459	326	3	-	-	PUNCT
fnp-3459	326	4	becerra	becerra	PROPN
fnp-3459	326	5	c	c	NOUN
fnp-3459	326	6	,	,	PUNCT
fnp-3459	326	7	filipello	filipello	PROPN
fnp-3459	326	8	f	f	PROPN
fnp-3459	326	9	,	,	PUNCT
fnp-3459	326	10	sandoval	sandoval	PROPN
fnp-3459	326	11	-	-	PUNCT
fnp-3459	326	12	hernández	hernández	PROPN
fnp-3459	326	13	a	a	X
fnp-3459	326	14	,	,	PUNCT
fnp-3459	326	15	arboleda	arboleda	PROPN
fnp-3459	326	16	h	h	NOUN
fnp-3459	326	17	,	,	PUNCT
fnp-3459	326	18	arboleda	arboleda	PROPN
fnp-3459	326	19	g.	g.	PROPN
fnp-3459	326	20	liver	liver	NOUN
fnp-3459	326	21	x	x	ADP
fnp-3459	326	22	receptor	receptor	NOUN
fnp-3459	326	23	agonist	agonist	NOUN
fnp-3459	326	24	gw3965	gw3965	NOUN
fnp-3459	326	25	regulates	regulate	VERB
fnp-3459	326	26	synaptic	synaptic	ADJ
fnp-3459	326	27	function	function	NOUN
fnp-3459	326	28	upon	upon	SCONJ
fnp-3459	326	29	amyloid	amyloid	NOUN
fnp-3459	326	30	beta	beta	ADJ
fnp-3459	326	31	exposure	exposure	NOUN
fnp-3459	326	32	in	in	ADP
fnp-3459	326	33	hippocampal	hippocampal	ADJ
fnp-3459	326	34	neurons	neuron	NOUN
fnp-3459	326	35	.	.	PUNCT
fnp-3459	327	1	neurotox	neurotox	PROPN
fnp-3459	327	2	res	res	PROPN
fnp-3459	327	3	.	.	PUNCT
fnp-3459	328	1	2018;33(3):569	2018;33(3):569	PROPN
fnp-3459	328	2	-	-	PUNCT
fnp-3459	328	3	79	79	NUM
fnp-3459	328	4	.	.	PUNCT
fnp-3459	329	1	https://doi.org/10.1007/s12640-017-9845-3	https://doi.org/10.1007/s12640-017-9845-3	PROPN
fnp-3459	329	2	cramer	cramer	PROPN
fnp-3459	329	3	pe	pe	PROPN
fnp-3459	329	4	,	,	PUNCT
fnp-3459	329	5	cirrito	cirrito	PROPN
fnp-3459	329	6	jr	jr	PROPN
fnp-3459	329	7	,	,	PUNCT
fnp-3459	329	8	wesson	wesson	PROPN
fnp-3459	329	9	dw	dw	PROPN
fnp-3459	329	10	,	,	PUNCT
fnp-3459	329	11	lee	lee	PROPN
fnp-3459	329	12	cyd	cyd	PROPN
fnp-3459	329	13	,	,	PUNCT
fnp-3459	329	14	karlo	karlo	PROPN
fnp-3459	329	15	jc	jc	PROPN
fnp-3459	329	16	,	,	PUNCT
fnp-3459	329	17	zinn	zinn	PROPN
fnp-3459	329	18	ae	ae	PROPN
fnp-3459	329	19	,	,	PUNCT
fnp-3459	329	20	et	et	PROPN
fnp-3459	329	21	al	al	PROPN
fnp-3459	329	22	.	.	PROPN
fnp-3459	329	23	apoe	apoe	PROPN
fnp-3459	329	24	-	-	PUNCT
fnp-3459	329	25	directed	direct	VERB
fnp-3459	329	26	therapeutics	therapeutic	NOUN
fnp-3459	329	27	rapidly	rapidly	ADV
fnp-3459	329	28	clear	clear	VERB
fnp-3459	329	29	β	β	NOUN
fnp-3459	329	30	-	-	NOUN
fnp-3459	329	31	amyloid	amyloid	NOUN
fnp-3459	329	32	and	and	CCONJ
fnp-3459	329	33	reverse	reverse	ADJ
fnp-3459	329	34	deficits	deficit	NOUN
fnp-3459	329	35	in	in	ADP
fnp-3459	329	36	ad	ad	NOUN
fnp-3459	329	37	mouse	mouse	NOUN
fnp-3459	329	38	models	model	NOUN
fnp-3459	329	39	.	.	PUNCT
fnp-3459	330	1	science	science	NOUN
fnp-3459	330	2	(	(	PUNCT
fnp-3459	330	3	new	new	PROPN
fnp-3459	330	4	york	york	PROPN
fnp-3459	330	5	,	,	PUNCT
fnp-3459	330	6	ny	ny	PROPN
fnp-3459	330	7	)	)	PUNCT
fnp-3459	330	8	.	.	PUNCT
fnp-3459	331	1	2012;335(6075):1503	2012;335(6075):1503	NUM
fnp-3459	331	2	-	-	SYM
fnp-3459	331	3	6	6	NUM
fnp-3459	331	4	.	.	PUNCT
fnp-3459	331	5	https://doi.org/10.1126/science.1217697	https://doi.org/10.1126/science.1217697	PROPN
fnp-3459	331	6	koudinov	koudinov	PROPN
fnp-3459	331	7	ar	ar	PROPN
fnp-3459	331	8	,	,	PUNCT
fnp-3459	331	9	koudinova	koudinova	PROPN
fnp-3459	331	10	nv	nv	PROPN
fnp-3459	331	11	.	.	PUNCT
fnp-3459	331	12	cholesterol	cholesterol	NOUN
fnp-3459	331	13	homeostasis	homeostasis	NOUN
fnp-3459	331	14	failure	failure	NOUN
fnp-3459	331	15	as	as	ADP
fnp-3459	331	16	a	a	DET
fnp-3459	331	17	unifying	unifying	ADJ
fnp-3459	331	18	cause	cause	NOUN
fnp-3459	331	19	of	of	ADP
fnp-3459	331	20	synaptic	synaptic	ADJ
fnp-3459	331	21	degeneration	degeneration	NOUN
fnp-3459	331	22	.	.	PUNCT
fnp-3459	332	1	j	j	PROPN
fnp-3459	332	2	neurol	neurol	PROPN
fnp-3459	332	3	sci	sci	PROPN
fnp-3459	332	4	.	.	PUNCT
fnp-3459	333	1	2005;229	2005;229	NUM
fnp-3459	333	2	-	-	PUNCT
fnp-3459	333	3	230:233	230:233	NUM
fnp-3459	333	4	-	-	PUNCT
fnp-3459	333	5	40	40	NUM
fnp-3459	333	6	.	.	PUNCT
fnp-3459	334	1	https://doi.org/10.1016/j.jns.2004.11.036	https://doi.org/10.1016/j.jns.2004.11.036	VERB
fnp-3459	334	2	mesulam	mesulam	PROPN
fnp-3459	334	3	mm	mm	PROPN
fnp-3459	334	4	.	.	PUNCT
fnp-3459	335	1	a	a	DET
fnp-3459	335	2	plasticity	plasticity	NOUN
fnp-3459	335	3	-	-	PUNCT
fnp-3459	335	4	based	base	VERB
fnp-3459	335	5	theory	theory	NOUN
fnp-3459	335	6	of	of	ADP
fnp-3459	335	7	the	the	DET
fnp-3459	335	8	pathogenesis	pathogenesis	NOUN
fnp-3459	335	9	of	of	ADP
fnp-3459	335	10	alzheimer	alzheimer	PROPN
fnp-3459	335	11	's	's	PART
fnp-3459	335	12	disease	disease	NOUN
fnp-3459	335	13	.	.	PUNCT
fnp-3459	336	1	ann	ann	PROPN
fnp-3459	336	2	n	n	PROPN
fnp-3459	336	3	y	y	PROPN
fnp-3459	336	4	acad	acad	PROPN
fnp-3459	336	5	sci	sci	PROPN
fnp-3459	336	6	.	.	PUNCT
fnp-3459	336	7	2000;924:42	2000;924:42	NUM
fnp-3459	336	8	-	-	SYM
fnp-3459	336	9	52	52	NUM
fnp-3459	336	10	.	.	PUNCT
fnp-3459	337	1	https://doi.org/10.1111/j.1749-6632.2000.tb05559.x	https://doi.org/10.1111/j.1749-6632.2000.tb05559.x	PROPN
fnp-3459	337	2	fan	fan	PROPN
fnp-3459	337	3	qw	qw	PROPN
fnp-3459	337	4	,	,	PUNCT
fnp-3459	337	5	yu	yu	PROPN
fnp-3459	337	6	w	w	PROPN
fnp-3459	337	7	,	,	PUNCT
fnp-3459	337	8	senda	senda	PROPN
fnp-3459	337	9	t	t	PROPN
fnp-3459	337	10	,	,	PUNCT
fnp-3459	337	11	yanagisawa	yanagisawa	PROPN
fnp-3459	337	12	k	k	PROPN
fnp-3459	337	13	,	,	PUNCT
fnp-3459	337	14	michikawa	michikawa	PROPN
fnp-3459	337	15	m.	m.	NOUN
fnp-3459	337	16	cholesterol	cholesterol	NOUN
fnp-3459	337	17	-	-	PUNCT
fnp-3459	337	18	dependent	dependent	ADJ
fnp-3459	337	19	modulation	modulation	NOUN
fnp-3459	337	20	of	of	ADP
fnp-3459	337	21	tau	tau	PROPN
fnp-3459	337	22	phosphorylation	phosphorylation	NOUN
fnp-3459	337	23	in	in	ADP
fnp-3459	337	24	cultured	cultured	ADJ
fnp-3459	337	25	neurons	neuron	NOUN
fnp-3459	337	26	.	.	PUNCT
fnp-3459	338	1	j	j	PROPN
fnp-3459	338	2	neurochem	neurochem	PROPN
fnp-3459	338	3	.	.	PUNCT
fnp-3459	339	1	2001;76(2):391	2001;76(2):391	NUM
fnp-3459	339	2	-	-	PUNCT
fnp-3459	339	3	400	400	NUM
fnp-3459	339	4	.	.	PUNCT
fnp-3459	340	1	https://doi.org/10.1046/j.1471-4159.2001.00063.x	https://doi.org/10.1046/j.1471-4159.2001.00063.x	VERB
fnp-3459	340	2	love	love	PROPN
fnp-3459	340	3	s	s	PROPN
fnp-3459	340	4	,	,	PUNCT
fnp-3459	340	5	bridges	bridge	NOUN
fnp-3459	340	6	lr	lr	NOUN
fnp-3459	340	7	,	,	PUNCT
fnp-3459	340	8	case	case	NOUN
fnp-3459	340	9	cp	cp	PROPN
fnp-3459	340	10	.	.	PROPN
fnp-3459	340	11	neurofibrillary	neurofibrillary	ADJ
fnp-3459	340	12	tangles	tangle	NOUN
fnp-3459	340	13	in	in	ADP
fnp-3459	340	14	niemann	niemann	PROPN
fnp-3459	340	15	-	-	PUNCT
fnp-3459	340	16	pick	pick	NOUN
fnp-3459	340	17	disease	disease	NOUN
fnp-3459	340	18	type	type	NOUN
fnp-3459	340	19	c.	c.	PROPN
fnp-3459	340	20	brain	brain	NOUN
fnp-3459	340	21	.	.	PUNCT
fnp-3459	341	1	1995;118	1995;118	NUM
fnp-3459	341	2	(	(	PUNCT
fnp-3459	341	3	pt	pt	NOUN
fnp-3459	341	4	1):119	1):119	PROPN
fnp-3459	341	5	-	-	SYM
fnp-3459	341	6	29	29	NUM
fnp-3459	341	7	.	.	PUNCT
fnp-3459	342	1	https://doi.org/10.1093/brain/118.1.119	https://doi.org/10.1093/brain/118.1.119	PROPN
fnp-3459	342	2	suzuki	suzuki	PROPN
fnp-3459	342	3	k	k	PROPN
fnp-3459	342	4	,	,	PUNCT
fnp-3459	342	5	parker	parker	PROPN
fnp-3459	342	6	cc	cc	PROPN
fnp-3459	342	7	,	,	PUNCT
fnp-3459	342	8	pentchev	pentchev	PROPN
fnp-3459	342	9	pg	pg	PROPN
fnp-3459	342	10	,	,	PUNCT
fnp-3459	342	11	katz	katz	PROPN
fnp-3459	342	12	d	d	PROPN
fnp-3459	342	13	,	,	PUNCT
fnp-3459	342	14	ghetti	ghetti	PROPN
fnp-3459	342	15	b	b	PROPN
fnp-3459	342	16	,	,	PUNCT
fnp-3459	342	17	d'agostino	d'agostino	PROPN
fnp-3459	342	18	an	an	PROPN
fnp-3459	342	19	,	,	PUNCT
fnp-3459	342	20	et	et	PROPN
fnp-3459	342	21	al	al	PROPN
fnp-3459	342	22	.	.	PROPN
fnp-3459	342	23	neurofibrillary	neurofibrillary	ADJ
fnp-3459	342	24	tangles	tangle	NOUN
fnp-3459	342	25	in	in	ADP
fnp-3459	342	26	niemann	niemann	PROPN
fnp-3459	342	27	-	-	PUNCT
fnp-3459	342	28	pick	pick	NOUN
fnp-3459	342	29	disease	disease	NOUN
fnp-3459	342	30	type	type	NOUN
fnp-3459	342	31	c.	c.	PROPN
fnp-3459	342	32	acta	acta	PROPN
fnp-3459	342	33	neuropathol	neuropathol	PROPN
fnp-3459	342	34	.	.	PUNCT
fnp-3459	343	1	1995;89(3):227	1995;89(3):227	NUM
fnp-3459	343	2	-	-	SYM
fnp-3459	343	3	38	38	NUM
fnp-3459	343	4	.	.	PUNCT
fnp-3459	344	1	https://doi.org/10.1007/bf00309338	https://doi.org/10.1007/bf00309338	PRON
fnp-3459	344	2	mckee	mckee	PROPN
fnp-3459	344	3	ac	ac	PROPN
fnp-3459	344	4	,	,	PUNCT
fnp-3459	344	5	cairns	cairns	PROPN
fnp-3459	344	6	nj	nj	PROPN
fnp-3459	344	7	,	,	PUNCT
fnp-3459	344	8	dickson	dickson	PROPN
fnp-3459	344	9	dw	dw	PROPN
fnp-3459	344	10	,	,	PUNCT
fnp-3459	344	11	folkerth	folkerth	PROPN
fnp-3459	344	12	rd	rd	PROPN
fnp-3459	344	13	,	,	PUNCT
fnp-3459	344	14	keene	keene	PROPN
fnp-3459	344	15	cd	cd	PROPN
fnp-3459	344	16	,	,	PUNCT
fnp-3459	344	17	litvan	litvan	PROPN
fnp-3459	344	18	i	i	PRON
fnp-3459	344	19	,	,	PUNCT
fnp-3459	344	20	et	et	PROPN
fnp-3459	344	21	al	al	PROPN
fnp-3459	344	22	.	.	PUNCT
fnp-3459	345	1	the	the	DET
fnp-3459	345	2	first	first	ADJ
fnp-3459	345	3	ninds	nind	NOUN
fnp-3459	345	4	/	/	SYM
fnp-3459	345	5	nibib	nibib	NOUN
fnp-3459	345	6	consensus	consensus	NOUN
fnp-3459	345	7	meeting	meeting	NOUN
fnp-3459	345	8	to	to	PART
fnp-3459	345	9	define	define	VERB
fnp-3459	345	10	neuropathological	neuropathological	ADJ
fnp-3459	345	11	criteria	criterion	NOUN
fnp-3459	345	12	for	for	ADP
fnp-3459	345	13	the	the	DET
fnp-3459	345	14	diagnosis	diagnosis	NOUN
fnp-3459	345	15	of	of	ADP
fnp-3459	345	16	chronic	chronic	ADJ
fnp-3459	345	17	traumatic	traumatic	ADJ
fnp-3459	345	18	encephalopathy	encephalopathy	NOUN
fnp-3459	345	19	.	.	PUNCT
fnp-3459	346	1	acta	acta	PROPN
fnp-3459	346	2	neuropathol	neuropathol	PROPN
fnp-3459	346	3	.	.	PUNCT
fnp-3459	347	1	2016;131(1):75	2016;131(1):75	PROPN
fnp-3459	347	2	-	-	SYM
fnp-3459	347	3	86	86	NUM
fnp-3459	347	4	.	.	PUNCT
fnp-3459	348	1	https://doi.org/10.1007/s00401-015-1515-z	https://doi.org/10.1007/s00401-015-1515-z	INTJ
fnp-3459	348	2	kay	kay	PROPN
fnp-3459	348	3	ad	ad	NOUN
fnp-3459	348	4	,	,	PUNCT
fnp-3459	348	5	petzold	petzold	VERB
fnp-3459	348	6	a	a	PRON
fnp-3459	348	7	,	,	PUNCT
fnp-3459	348	8	kerr	kerr	PROPN
fnp-3459	348	9	m	m	PROPN
fnp-3459	348	10	,	,	PUNCT
fnp-3459	348	11	keir	keir	PROPN
fnp-3459	348	12	g	g	PROPN
fnp-3459	348	13	,	,	PUNCT
fnp-3459	348	14	thompson	thompson	PROPN
fnp-3459	348	15	ej	ej	PROPN
fnp-3459	348	16	,	,	PUNCT
fnp-3459	348	17	nicoll	nicoll	PROPN
fnp-3459	348	18	ja	ja	PROPN
fnp-3459	348	19	.	.	PUNCT
fnp-3459	348	20	cerebrospinal	cerebrospinal	ADJ
fnp-3459	348	21	fluid	fluid	NOUN
fnp-3459	348	22	apolipoprotein	apolipoprotein	NOUN
fnp-3459	348	23	e	e	NOUN
fnp-3459	348	24	concentration	concentration	NOUN
fnp-3459	348	25	decreases	decrease	NOUN
fnp-3459	348	26	after	after	ADP
fnp-3459	348	27	traumatic	traumatic	ADJ
fnp-3459	348	28	brain	brain	NOUN
fnp-3459	348	29	injury	injury	NOUN
fnp-3459	348	30	.	.	PUNCT
fnp-3459	349	1	j	j	PROPN
fnp-3459	349	2	neurotrauma	neurotrauma	PROPN
fnp-3459	349	3	.	.	PUNCT
fnp-3459	350	1	2003;20(3):243	2003;20(3):243	NUM
fnp-3459	350	2	-	-	PUNCT
fnp-3459	350	3	50	50	NUM
fnp-3459	350	4	.	.	PUNCT
fnp-3459	351	1	https://doi.org/10.1089/089771503321532824	https://doi.org/10.1089/089771503321532824	NUM
fnp-3459	351	2	kay	kay	PROPN
fnp-3459	351	3	ad	ad	NOUN
fnp-3459	351	4	,	,	PUNCT
fnp-3459	351	5	day	day	NOUN
fnp-3459	351	6	sp	sp	NOUN
fnp-3459	351	7	,	,	PUNCT
fnp-3459	351	8	kerr	kerr	PROPN
fnp-3459	351	9	m	m	PROPN
fnp-3459	351	10	,	,	PUNCT
fnp-3459	351	11	nicoll	nicoll	PROPN
fnp-3459	351	12	ja	ja	PROPN
fnp-3459	351	13	,	,	PUNCT
fnp-3459	351	14	packard	packard	PROPN
fnp-3459	351	15	cj	cj	PROPN
fnp-3459	351	16	,	,	PUNCT
fnp-3459	351	17	caslake	caslake	PROPN
fnp-3459	351	18	mj	mj	PROPN
fnp-3459	351	19	.	.	PUNCT
fnp-3459	352	1	remodeling	remodeling	NOUN
fnp-3459	352	2	of	of	ADP
fnp-3459	352	3	cerebrospinal	cerebrospinal	ADJ
fnp-3459	352	4	fluid	fluid	ADJ
fnp-3459	352	5	lipoprotein	lipoprotein	ADJ
fnp-3459	352	6	particles	particle	NOUN
fnp-3459	352	7	after	after	ADP
fnp-3459	352	8	human	human	PROPN
fnp-3459	352	9	traumatic	traumatic	ADJ
fnp-3459	352	10	brain	brain	NOUN
fnp-3459	352	11	injury	injury	NOUN
fnp-3459	352	12	.	.	PUNCT
fnp-3459	353	1	j	j	PROPN
fnp-3459	353	2	neurotrauma	neurotrauma	PROPN
fnp-3459	353	3	.	.	PUNCT
fnp-3459	354	1	2003;20(8):717	2003;20(8):717	PROPN
fnp-3459	354	2	-	-	PUNCT
fnp-3459	354	3	23	23	NUM
fnp-3459	354	4	.	.	PUNCT
fnp-3459	355	1	https://doi.org/10.1089/089771503767869953	https://doi.org/10.1089/089771503767869953	NUM
fnp-3459	355	2	kay	kay	PROPN
fnp-3459	355	3	ad	ad	NOUN
fnp-3459	355	4	,	,	PUNCT
fnp-3459	355	5	petzold	petzold	VERB
fnp-3459	355	6	a	a	PRON
fnp-3459	355	7	,	,	PUNCT
fnp-3459	355	8	kerr	kerr	PROPN
fnp-3459	355	9	m	m	PROPN
fnp-3459	355	10	,	,	PUNCT
fnp-3459	355	11	keir	keir	PROPN
fnp-3459	355	12	g	g	PROPN
fnp-3459	355	13	,	,	PUNCT
fnp-3459	355	14	thompson	thompson	PROPN
fnp-3459	355	15	e	e	PROPN
fnp-3459	355	16	,	,	PUNCT
fnp-3459	355	17	nicoll	nicoll	PROPN
fnp-3459	355	18	ja	ja	PROPN
fnp-3459	355	19	.	.	PUNCT
fnp-3459	355	20	alterations	alteration	NOUN
fnp-3459	355	21	in	in	ADP
fnp-3459	355	22	cerebrospinal	cerebrospinal	ADJ
fnp-3459	355	23	fluid	fluid	NOUN
fnp-3459	355	24	apolipoprotein	apolipoprotein	ADJ
fnp-3459	355	25	e	e	NOUN
fnp-3459	355	26	and	and	CCONJ
fnp-3459	355	27	amyloid	amyloid	VERB
fnp-3459	355	28	beta	beta	NOUN
fnp-3459	355	29	-	-	PUNCT
fnp-3459	355	30	protein	protein	NOUN
fnp-3459	355	31	after	after	ADP
fnp-3459	355	32	traumatic	traumatic	ADJ
fnp-3459	355	33	brain	brain	NOUN
fnp-3459	355	34	injury	injury	NOUN
fnp-3459	355	35	.	.	PUNCT
fnp-3459	356	1	j	j	PROPN
fnp-3459	356	2	neurotrauma	neurotrauma	PROPN
fnp-3459	356	3	.	.	PUNCT
fnp-3459	357	1	2003;20(10):943	2003;20(10):943	PROPN
fnp-3459	357	2	-	-	PUNCT
fnp-3459	357	3	52	52	NUM
fnp-3459	357	4	.	.	PUNCT
fnp-3459	358	1	https://doi.org/10.1089/089771503770195795	https://doi.org/10.1089/089771503770195795	PUNCT
fnp-3459	358	2	zhao	zhao	PROPN
fnp-3459	358	3	j	j	PROPN
fnp-3459	358	4	,	,	PUNCT
fnp-3459	358	5	fu	fu	PROPN
fnp-3459	358	6	y	y	PROPN
fnp-3459	358	7	,	,	PUNCT
fnp-3459	358	8	yamazaki	yamazaki	PROPN
fnp-3459	358	9	y	y	PROPN
fnp-3459	358	10	,	,	PUNCT
fnp-3459	358	11	ren	ren	PROPN
fnp-3459	358	12	y	y	PROPN
fnp-3459	358	13	,	,	PUNCT
fnp-3459	358	14	davis	davis	PROPN
fnp-3459	358	15	md	md	PROPN
fnp-3459	358	16	,	,	PUNCT
fnp-3459	358	17	liu	liu	PROPN
fnp-3459	358	18	c	c	PROPN
fnp-3459	358	19	-	-	PUNCT
fnp-3459	358	20	c	c	PROPN
fnp-3459	358	21	,	,	PUNCT
fnp-3459	358	22	et	et	PROPN
fnp-3459	358	23	al	al	PROPN
fnp-3459	358	24	.	.	PUNCT
fnp-3459	358	25	apoe4	apoe4	PROPN
fnp-3459	358	26	exacerbates	exacerbate	VERB
fnp-3459	358	27	synapse	synapse	VERB
fnp-3459	358	28	loss	loss	NOUN
fnp-3459	358	29	and	and	CCONJ
fnp-3459	358	30	neurodegeneration	neurodegeneration	NOUN
fnp-3459	358	31	in	in	ADP
fnp-3459	358	32	alzheimer	alzheimer	PROPN
fnp-3459	358	33	’s	’s	PART
fnp-3459	358	34	disease	disease	PROPN
fnp-3459	358	35	patient	patient	PROPN
fnp-3459	358	36	ipsc	ipsc	NOUN
fnp-3459	358	37	-	-	PUNCT
fnp-3459	358	38	derived	derive	VERB
fnp-3459	358	39	cerebral	cerebral	ADJ
fnp-3459	358	40	organoids	organoid	NOUN
fnp-3459	358	41	.	.	PUNCT
fnp-3459	359	1	nature	nature	NOUN
fnp-3459	359	2	communications	communication	NOUN
fnp-3459	359	3	.	.	PUNCT
fnp-3459	360	1	2020;11(1):5540	2020;11(1):5540	NUM
fnp-3459	360	2	.	.	PUNCT
fnp-3459	361	1	https://doi.org/10.1038/s41467-020-19264-0	https://doi.org/10.1038/s41467-020-19264-0	PROPN
fnp-3459	361	2	horsburgh	horsburgh	PROPN
fnp-3459	361	3	k	k	PROPN
fnp-3459	361	4	,	,	PUNCT
fnp-3459	361	5	mccarron	mccarron	PROPN
fnp-3459	361	6	mo	mo	PROPN
fnp-3459	361	7	,	,	PUNCT
fnp-3459	361	8	white	white	PROPN
fnp-3459	361	9	f	f	PROPN
fnp-3459	361	10	,	,	PUNCT
fnp-3459	361	11	nicoll	nicoll	PROPN
fnp-3459	361	12	ja	ja	PROPN
fnp-3459	361	13	.	.	PUNCT
fnp-3459	362	1	the	the	DET
fnp-3459	362	2	role	role	NOUN
fnp-3459	362	3	of	of	ADP
fnp-3459	362	4	apolipoprotein	apolipoprotein	ADJ
fnp-3459	362	5	e	e	PROPN
fnp-3459	362	6	in	in	ADP
fnp-3459	362	7	alzheimer	alzheimer	PROPN
fnp-3459	362	8	's	's	PART
fnp-3459	362	9	disease	disease	NOUN
fnp-3459	362	10	,	,	PUNCT
fnp-3459	362	11	acute	acute	ADJ
fnp-3459	362	12	brain	brain	NOUN
fnp-3459	362	13	injury	injury	NOUN
fnp-3459	362	14	and	and	CCONJ
fnp-3459	362	15	cerebrovascular	cerebrovascular	ADJ
fnp-3459	362	16	disease	disease	NOUN
fnp-3459	362	17	:	:	PUNCT
fnp-3459	362	18	evidence	evidence	NOUN
fnp-3459	362	19	of	of	ADP
fnp-3459	362	20	common	common	ADJ
fnp-3459	362	21	mechanisms	mechanism	NOUN
fnp-3459	362	22	and	and	CCONJ
fnp-3459	362	23	utility	utility	NOUN
fnp-3459	362	24	of	of	ADP
fnp-3459	362	25	animal	animal	NOUN
fnp-3459	362	26	models	model	NOUN
fnp-3459	362	27	.	.	PUNCT
fnp-3459	363	1	neurobiol	neurobiol	PROPN
fnp-3459	363	2	aging	aging	NOUN
fnp-3459	363	3	.	.	PUNCT
fnp-3459	364	1	2000;21(2):245	2000;21(2):245	NUM
fnp-3459	364	2	-	-	PROPN
fnp-3459	364	3	55	55	NUM
fnp-3459	364	4	.	.	PUNCT
fnp-3459	365	1	https://doi.org/10.1016/s0197-4580(00)00097-x	https://doi.org/10.1016/s0197-4580(00)00097-x	VERB
fnp-3459	365	2	heinsinger	heinsinger	PROPN
fnp-3459	365	3	nm	nm	PROPN
fnp-3459	365	4	,	,	PUNCT
fnp-3459	365	5	gachechiladze	gachechiladze	PROPN
fnp-3459	365	6	ma	ma	PROPN
fnp-3459	365	7	,	,	PUNCT
fnp-3459	365	8	rebeck	rebeck	VERB
fnp-3459	365	9	gw	gw	PROPN
fnp-3459	365	10	.	.	PUNCT
fnp-3459	366	1	apolipoprotein	apolipoprotein	PROPN
fnp-3459	366	2	e	e	PROPN
fnp-3459	366	3	genotype	genotype	NOUN
fnp-3459	366	4	affects	affect	VERB
fnp-3459	366	5	size	size	NOUN
fnp-3459	366	6	of	of	ADP
fnp-3459	366	7	apoe	apoe	ADJ
fnp-3459	366	8	complexes	complex	NOUN
fnp-3459	366	9	in	in	ADP
fnp-3459	366	10	cerebrospinal	cerebrospinal	ADJ
fnp-3459	366	11	fluid	fluid	NOUN
fnp-3459	366	12	.	.	PUNCT
fnp-3459	367	1	journal	journal	NOUN
fnp-3459	367	2	of	of	ADP
fnp-3459	367	3	neuropathology	neuropathology	NOUN
fnp-3459	367	4	&	&	CCONJ
fnp-3459	367	5	experimental	experimental	ADJ
fnp-3459	367	6	neurology	neurology	NOUN
fnp-3459	367	7	.	.	PUNCT
fnp-3459	368	1	2016;75(10):918	2016;75(10):918	NOUN
fnp-3459	368	2	-	-	SYM
fnp-3459	368	3	24	24	NUM
fnp-3459	368	4	.	.	PUNCT
fnp-3459	369	1	https://doi.org/10.1093/jnen/nlw067	https://doi.org/10.1093/jnen/nlw067	PROPN
fnp-3459	369	2	zhao	zhao	PROPN
fnp-3459	369	3	j	j	PROPN
fnp-3459	369	4	,	,	PUNCT
fnp-3459	369	5	davis	davis	PROPN
fnp-3459	369	6	md	md	PROPN
fnp-3459	369	7	,	,	PUNCT
fnp-3459	369	8	martens	martens	PROPN
fnp-3459	369	9	ya	ya	PROPN
fnp-3459	369	10	,	,	PUNCT
fnp-3459	369	11	shinohara	shinohara	PROPN
fnp-3459	369	12	m	m	PROPN
fnp-3459	369	13	,	,	PUNCT
fnp-3459	369	14	graff	graff	NOUN
fnp-3459	369	15	-	-	PUNCT
fnp-3459	369	16	radford	radford	PROPN
fnp-3459	369	17	nr	nr	PROPN
fnp-3459	369	18	,	,	PUNCT
fnp-3459	369	19	younkin	younkin	NOUN
fnp-3459	369	20	sg	sg	PROPN
fnp-3459	369	21	,	,	PUNCT
fnp-3459	369	22	et	et	PROPN
fnp-3459	369	23	al	al	PROPN
fnp-3459	369	24	.	.	PROPN
fnp-3459	370	1	apoe	apoe	PROPN
fnp-3459	370	2	epsilon4	epsilon4	NOUN
fnp-3459	370	3	/	/	SYM
fnp-3459	370	4	epsilon4	epsilon4	PROPN
fnp-3459	370	5	diminishes	diminish	VERB
fnp-3459	370	6	neurotrophic	neurotrophic	ADJ
fnp-3459	370	7	function	function	NOUN
fnp-3459	370	8	of	of	ADP
fnp-3459	370	9	human	human	ADJ
fnp-3459	370	10	ipsc	ipsc	NOUN
fnp-3459	370	11	-	-	PUNCT
fnp-3459	370	12	derived	derive	VERB
fnp-3459	370	13	astrocytes	astrocyte	NOUN
fnp-3459	370	14	.	.	PUNCT
fnp-3459	371	1	hum	hum	PROPN
fnp-3459	371	2	mol	mol	ADP
fnp-3459	371	3	genet	genet	NOUN
fnp-3459	371	4	.	.	PUNCT
fnp-3459	372	1	2017;26(14):2690	2017;26(14):2690	NUM
fnp-3459	372	2	-	-	SYM
fnp-3459	372	3	700	700	NUM
fnp-3459	372	4	.	.	PUNCT
fnp-3459	373	1	https://doi.org/10.1093/hmg/ddx155	https://doi.org/10.1093/hmg/ddx155	PROPN
fnp-3459	373	2	boche	boche	PROPN
fnp-3459	373	3	d	d	PROPN
fnp-3459	373	4	,	,	PUNCT
fnp-3459	373	5	nicoll	nicoll	PROPN
fnp-3459	373	6	jar	jar	PROPN
fnp-3459	373	7	.	.	PROPN
fnp-3459	373	8	invited	invite	VERB
fnp-3459	373	9	review	review	NOUN
fnp-3459	373	10	understanding	understanding	NOUN
fnp-3459	373	11	cause	cause	NOUN
fnp-3459	373	12	and	and	CCONJ
fnp-3459	373	13	effect	effect	NOUN
fnp-3459	373	14	in	in	ADP
fnp-3459	373	15	alzheimer	alzheimer	PROPN
fnp-3459	373	16	's	's	PART
fnp-3459	373	17	pathophysiology	pathophysiology	NOUN
fnp-3459	373	18	:	:	PUNCT
fnp-3459	373	19	implications	implication	NOUN
fnp-3459	373	20	for	for	ADP
fnp-3459	373	21	clinical	clinical	ADJ
fnp-3459	373	22	trials	trial	NOUN
fnp-3459	373	23	.	.	PUNCT
fnp-3459	374	1	neuropathol	neuropathol	NOUN
fnp-3459	374	2	appl	appl	PROPN
fnp-3459	374	3	neurobiol	neurobiol	PROPN
fnp-3459	374	4	.	.	PUNCT
fnp-3459	375	1	2020;46(7):623	2020;46(7):623	NUM
fnp-3459	375	2	-	-	PUNCT
fnp-3459	375	3	40	40	NUM
fnp-3459	375	4	.	.	PUNCT
fnp-3459	376	1	https://doi.org/10.1111/nan.12642	https://doi.org/10.1111/nan.12642	PROPN
fnp-3459	376	2	franco	franco	PROPN
fnp-3459	376	3	-	-	PUNCT
fnp-3459	376	4	bocanegra	bocanegra	PROPN
fnp-3459	376	5	dk	dk	PROPN
fnp-3459	376	6	,	,	PUNCT
fnp-3459	376	7	gourari	gourari	PROPN
fnp-3459	376	8	y	y	PROPN
fnp-3459	376	9	,	,	PUNCT
fnp-3459	376	10	mcauley	mcauley	PROPN
fnp-3459	376	11	c	c	PROPN
fnp-3459	376	12	,	,	PUNCT
fnp-3459	376	13	chatelet	chatelet	PROPN
fnp-3459	376	14	ds	ds	PROPN
fnp-3459	376	15	,	,	PUNCT
fnp-3459	376	16	johnston	johnston	PROPN
fnp-3459	376	17	da	da	PROPN
fnp-3459	376	18	,	,	PUNCT
fnp-3459	376	19	nicoll	nicoll	PROPN
fnp-3459	376	20	jar	jar	PROPN
fnp-3459	376	21	,	,	PUNCT
fnp-3459	376	22	et	et	PROPN
fnp-3459	376	23	al	al	PROPN
fnp-3459	376	24	.	.	PROPN
fnp-3459	376	25	microglial	microglial	ADJ
fnp-3459	376	26	morphology	morphology	NOUN
fnp-3459	376	27	in	in	ADP
fnp-3459	376	28	alzheimer	alzheimer	PROPN
fnp-3459	376	29	's	's	PART
fnp-3459	376	30	disease	disease	NOUN
fnp-3459	376	31	and	and	CCONJ
fnp-3459	376	32	after	after	ADP
fnp-3459	376	33	abeta	abeta	PRON
fnp-3459	376	34	immunotherapy	immunotherapy	NOUN
fnp-3459	376	35	.	.	PUNCT
fnp-3459	377	1	sci	sci	PROPN
fnp-3459	377	2	rep	rep	PROPN
fnp-3459	377	3	.	.	PROPN
fnp-3459	377	4	2021;11(1):15955	2021;11(1):15955	NUM
fnp-3459	377	5	.	.	PUNCT
fnp-3459	377	6	https://doi.org/10.1038/s41598-021-95535-0	https://doi.org/10.1038/s41598-021-95535-0	NUM
fnp-3459	377	7	jones	jones	PROPN
fnp-3459	377	8	l	l	PROPN
fnp-3459	377	9	,	,	PUNCT
fnp-3459	377	10	holmans	holmans	PROPN
fnp-3459	377	11	pa	pa	PROPN
fnp-3459	377	12	,	,	PUNCT
fnp-3459	377	13	hamshere	hamshere	NOUN
fnp-3459	377	14	ml	ml	PROPN
fnp-3459	377	15	,	,	PUNCT
fnp-3459	377	16	harold	harold	PROPN
fnp-3459	377	17	d	d	PROPN
fnp-3459	377	18	,	,	PUNCT
fnp-3459	377	19	moskvina	moskvina	PROPN
fnp-3459	377	20	v	v	NOUN
fnp-3459	377	21	,	,	PUNCT
fnp-3459	377	22	ivanov	ivanov	PROPN
fnp-3459	377	23	d	d	PROPN
fnp-3459	377	24	,	,	PUNCT
fnp-3459	377	25	et	et	PROPN
fnp-3459	377	26	al	al	PROPN
fnp-3459	377	27	.	.	PUNCT
fnp-3459	378	1	genetic	genetic	ADJ
fnp-3459	378	2	evidence	evidence	NOUN
fnp-3459	378	3	implicates	implicate	VERB
fnp-3459	378	4	the	the	DET
fnp-3459	378	5	immune	immune	ADJ
fnp-3459	378	6	system	system	NOUN
fnp-3459	378	7	and	and	CCONJ
fnp-3459	378	8	cholesterol	cholesterol	NOUN
fnp-3459	378	9	metabolism	metabolism	NOUN
fnp-3459	378	10	in	in	ADP
fnp-3459	378	11	the	the	DET
fnp-3459	378	12	aetiology	aetiology	NOUN
fnp-3459	378	13	of	of	ADP
fnp-3459	378	14	alzheimer	alzheimer	PROPN
fnp-3459	378	15	's	's	PART
fnp-3459	378	16	disease	disease	NOUN
fnp-3459	378	17	.	.	PUNCT
fnp-3459	379	1	plos	plos	PROPN
fnp-3459	379	2	one	one	NUM
fnp-3459	379	3	.	.	PUNCT
fnp-3459	380	1	2010;5(11):e13950	2010;5(11):e13950	NUM
fnp-3459	380	2	.	.	PUNCT
fnp-3459	381	1	https://doi.org/10.1371/journal.pone.0013950	https://doi.org/10.1371/journal.pone.0013950	PROPN
fnp-3459	381	2	boche	boche	PROPN
fnp-3459	381	3	d	d	PROPN
fnp-3459	381	4	,	,	PUNCT
fnp-3459	381	5	perry	perry	PROPN
fnp-3459	381	6	vh	vh	PROPN
fnp-3459	381	7	,	,	PUNCT
fnp-3459	381	8	nicoll	nicoll	PROPN
fnp-3459	381	9	jar	jar	PROPN
fnp-3459	381	10	.	.	PUNCT
fnp-3459	382	1	review	review	NOUN
fnp-3459	382	2	:	:	PUNCT
fnp-3459	382	3	activation	activation	NOUN
fnp-3459	382	4	patterns	pattern	NOUN
fnp-3459	382	5	of	of	ADP
fnp-3459	382	6	microglia	microglia	NOUN
fnp-3459	382	7	and	and	CCONJ
fnp-3459	382	8	their	their	PRON
fnp-3459	382	9	identification	identification	NOUN
fnp-3459	382	10	in	in	ADP
fnp-3459	382	11	the	the	DET
fnp-3459	382	12	human	human	ADJ
fnp-3459	382	13	brain	brain	NOUN
fnp-3459	382	14	.	.	PUNCT
fnp-3459	383	1	neuropathology	neuropathology	NOUN
fnp-3459	383	2	and	and	CCONJ
fnp-3459	383	3	applied	apply	VERB
fnp-3459	383	4	neurobiology	neurobiology	NOUN
fnp-3459	383	5	.	.	PUNCT
fnp-3459	384	1	2013;39(1):3	2013;39(1):3	NUM
fnp-3459	384	2	-	-	SYM
fnp-3459	384	3	18	18	NUM
fnp-3459	384	4	.	.	PUNCT
fnp-3459	385	1	https://doi.org/10.1111/nan.12011	https://doi.org/10.1111/nan.12011	ADJ
fnp-3459	385	2	torrandell	torrandell	NOUN
fnp-3459	385	3	-	-	PUNCT
fnp-3459	385	4	haro	haro	NOUN
fnp-3459	385	5	g	g	NOUN
fnp-3459	385	6	,	,	PUNCT
fnp-3459	385	7	branigan	branigan	PROPN
fnp-3459	385	8	gl	gl	PROPN
fnp-3459	385	9	,	,	PUNCT
fnp-3459	385	10	vitali	vitali	PROPN
fnp-3459	385	11	f	f	PROPN
fnp-3459	385	12	,	,	PUNCT
fnp-3459	385	13	geifman	geifman	NOUN
fnp-3459	385	14	n	n	PRON
fnp-3459	385	15	,	,	PUNCT
fnp-3459	385	16	zissimopoulos	zissimopoulos	PROPN
fnp-3459	385	17	jm	jm	PROPN
fnp-3459	385	18	,	,	PUNCT
fnp-3459	385	19	brinton	brinton	PROPN
fnp-3459	385	20	rd	rd	PROPN
fnp-3459	385	21	.	.	PUNCT
fnp-3459	386	1	statin	statin	PROPN
fnp-3459	386	2	therapy	therapy	NOUN
fnp-3459	386	3	and	and	CCONJ
fnp-3459	386	4	risk	risk	NOUN
fnp-3459	386	5	of	of	ADP
fnp-3459	386	6	alzheimer	alzheimer	PROPN
fnp-3459	386	7	's	's	PART
fnp-3459	386	8	and	and	CCONJ
fnp-3459	386	9	age	age	NOUN
fnp-3459	386	10	-	-	PUNCT
fnp-3459	386	11	related	relate	VERB
fnp-3459	386	12	neurodegenerative	neurodegenerative	ADJ
fnp-3459	386	13	diseases	disease	NOUN
fnp-3459	386	14	.	.	PUNCT
fnp-3459	387	1	alzheimers	alzheimers	PROPN
fnp-3459	387	2	dement	dement	PROPN
fnp-3459	387	3	(	(	PUNCT
fnp-3459	387	4	n	n	NOUN
fnp-3459	387	5	y	y	PROPN
fnp-3459	387	6	)	)	PUNCT
fnp-3459	387	7	.	.	PUNCT
fnp-3459	388	1	2020;6(1):e12108	2020;6(1):e12108	NUM
fnp-3459	388	2	.	.	PUNCT
fnp-3459	389	1	https://doi.org/10.1002/trc2.12108	https://doi.org/10.1002/trc2.12108	PROPN
fnp-3459	389	2	cibičková	cibičková	PROPN
fnp-3459	389	3	l.	l.	PROPN
fnp-3459	389	4	statins	statins	PROPN
fnp-3459	389	5	and	and	CCONJ
fnp-3459	389	6	their	their	PRON
fnp-3459	389	7	influence	influence	NOUN
fnp-3459	389	8	on	on	ADP
fnp-3459	389	9	brain	brain	NOUN
fnp-3459	389	10	cholesterol	cholesterol	NOUN
fnp-3459	389	11	.	.	PUNCT
fnp-3459	390	1	j	j	PROPN
fnp-3459	390	2	clin	clin	PROPN
fnp-3459	390	3	lipidol	lipidol	VERB
fnp-3459	390	4	.	.	PUNCT
fnp-3459	391	1	2011;5(5):373	2011;5(5):373	NUM
fnp-3459	391	2	-	-	SYM
fnp-3459	391	3	9	9	NUM
fnp-3459	391	4	.	.	PUNCT
fnp-3459	392	1	https://doi.org/10.1016/j.jacl.2011.06.007	https://doi.org/10.1016/j.jacl.2011.06.007	ADJ
fnp-3459	392	2	holmes	holmes	PROPN
fnp-3459	392	3	c	c	PROPN
fnp-3459	392	4	,	,	PUNCT
fnp-3459	392	5	boche	boche	PROPN
fnp-3459	392	6	d	d	PROPN
fnp-3459	392	7	,	,	PUNCT
fnp-3459	392	8	wilkinson	wilkinson	PROPN
fnp-3459	392	9	d	d	PROPN
fnp-3459	392	10	,	,	PUNCT
fnp-3459	392	11	yadegarfar	yadegarfar	ADV
fnp-3459	392	12	g	g	PROPN
fnp-3459	392	13	,	,	PUNCT
fnp-3459	392	14	hopkins	hopkins	PROPN
fnp-3459	392	15	v	v	NOUN
fnp-3459	392	16	,	,	PUNCT
fnp-3459	392	17	bayer	bayer	PROPN
fnp-3459	392	18	a	a	PROPN
fnp-3459	392	19	,	,	PUNCT
fnp-3459	392	20	et	et	PROPN
fnp-3459	392	21	al	al	PROPN
fnp-3459	392	22	.	.	PUNCT
fnp-3459	393	1	long	long	ADJ
fnp-3459	393	2	-	-	PUNCT
fnp-3459	393	3	term	term	NOUN
fnp-3459	393	4	effects	effect	NOUN
fnp-3459	393	5	of	of	ADP
fnp-3459	393	6	abeta42	abeta42	NOUN
fnp-3459	393	7	immunisation	immunisation	NOUN
fnp-3459	393	8	in	in	ADP
fnp-3459	393	9	alzheimer	alzheimer	PROPN
fnp-3459	393	10	's	's	PART
fnp-3459	393	11	disease	disease	NOUN
fnp-3459	393	12	:	:	PUNCT
fnp-3459	393	13	follow	follow	VERB
fnp-3459	393	14	-	-	PUNCT
fnp-3459	393	15	up	up	NOUN
fnp-3459	393	16	of	of	ADP
fnp-3459	393	17	a	a	DET
fnp-3459	393	18	randomised	randomise	VERB
fnp-3459	393	19	,	,	PUNCT
fnp-3459	393	20	placebo	placebo	NOUN
fnp-3459	393	21	-	-	PUNCT
fnp-3459	393	22	controlled	control	VERB
fnp-3459	393	23	phase	phase	NOUN
fnp-3459	393	24	i	i	PRON
fnp-3459	393	25	trial	trial	NOUN
fnp-3459	393	26	.	.	PUNCT
fnp-3459	394	1	lancet	lancet	NOUN
fnp-3459	394	2	.	.	PUNCT
fnp-3459	395	1	2008;372(9634):216	2008;372(9634):216	NUM
fnp-3459	395	2	-	-	SYM
fnp-3459	395	3	23	23	NUM
fnp-3459	395	4	.	.	PUNCT
fnp-3459	396	1	https://doi.org/10.1016/s0140-6736(08)61075-2	https://doi.org/10.1016/s0140-6736(08)61075-2	VERB
fnp-3459	396	2	copyright	copyright	NOUN
fnp-3459	396	3	:	:	PUNCT
fnp-3459	396	4	©	©	PROPN
fnp-3459	396	5	2021	2021	NUM
fnp-3459	396	6	the	the	DET
fnp-3459	396	7	author(s	author(s	NOUN
fnp-3459	396	8	)	)	PUNCT
fnp-3459	396	9	.	.	PUNCT
fnp-3459	397	1	this	this	PRON
fnp-3459	397	2	is	be	AUX
fnp-3459	397	3	an	an	DET
fnp-3459	397	4	open	open	ADJ
fnp-3459	397	5	access	access	NOUN
fnp-3459	397	6	article	article	NOUN
fnp-3459	397	7	distributed	distribute	VERB
fnp-3459	397	8	under	under	ADP
fnp-3459	397	9	the	the	DET
fnp-3459	397	10	terms	term	NOUN
fnp-3459	397	11	of	of	ADP
fnp-3459	397	12	the	the	DET
fnp-3459	397	13	creative	creative	ADJ
fnp-3459	397	14	commons	common	NOUN
fnp-3459	397	15	attribution	attribution	NOUN
fnp-3459	397	16	4.0	4.0	NUM
fnp-3459	397	17	international	international	ADJ
fnp-3459	397	18	license	license	NOUN
fnp-3459	397	19	(	(	PUNCT
fnp-3459	397	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-3459	397	21	)	)	PUNCT
fnp-3459	397	22	,	,	PUNCT
fnp-3459	397	23	which	which	PRON
fnp-3459	397	24	permits	permit	VERB
fnp-3459	397	25	unrestricted	unrestricted	ADJ
fnp-3459	397	26	use	use	NOUN
fnp-3459	397	27	,	,	PUNCT
fnp-3459	397	28	distribution	distribution	NOUN
fnp-3459	397	29	,	,	PUNCT
fnp-3459	397	30	and	and	CCONJ
fnp-3459	397	31	reproduction	reproduction	NOUN
fnp-3459	397	32	in	in	ADP
fnp-3459	397	33	any	any	DET
fnp-3459	397	34	medium	medium	NOUN
fnp-3459	397	35	,	,	PUNCT
fnp-3459	397	36	provided	provide	VERB
fnp-3459	397	37	the	the	DET
fnp-3459	397	38	original	original	ADJ
fnp-3459	397	39	author	author	NOUN
fnp-3459	397	40	and	and	CCONJ
fnp-3459	397	41	source	source	NOUN
fnp-3459	397	42	are	be	AUX
fnp-3459	397	43	credited	credit	VERB
fnp-3459	397	44	,	,	PUNCT
fnp-3459	397	45	a	a	DET
fnp-3459	397	46	link	link	NOUN
fnp-3459	397	47	to	to	ADP
fnp-3459	397	48	the	the	DET
fnp-3459	397	49	creative	creative	ADJ
fnp-3459	397	50	commons	common	NOUN
fnp-3459	397	51	license	license	NOUN
fnp-3459	397	52	is	be	AUX
fnp-3459	397	53	provided	provide	VERB
fnp-3459	397	54	,	,	PUNCT
fnp-3459	397	55	and	and	CCONJ
fnp-3459	397	56	any	any	DET
fnp-3459	397	57	changes	change	NOUN
fnp-3459	397	58	are	be	AUX
fnp-3459	397	59	indicated	indicate	VERB
fnp-3459	397	60	.	.	PUNCT
fnp-3459	398	1	the	the	DET
fnp-3459	398	2	creative	creative	ADJ
fnp-3459	398	3	commons	common	NOUN
fnp-3459	398	4	public	public	ADJ
fnp-3459	398	5	domain	domain	NOUN
fnp-3459	398	6	dedication	dedication	NOUN
fnp-3459	398	7	waiver	waiver	NOUN
fnp-3459	398	8	(	(	PUNCT
fnp-3459	398	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-3459	398	10	)	)	PUNCT
fnp-3459	398	11	applies	apply	VERB
fnp-3459	398	12	to	to	ADP
fnp-3459	398	13	the	the	DET
fnp-3459	398	14	data	datum	NOUN
fnp-3459	398	15	made	make	VERB
fnp-3459	398	16	available	available	ADJ
fnp-3459	398	17	in	in	ADP
fnp-3459	398	18	this	this	DET
fnp-3459	398	19	article	article	NOUN
fnp-3459	398	20	,	,	PUNCT
fnp-3459	398	21	unless	unless	SCONJ
fnp-3459	398	22	otherwise	otherwise	ADV
fnp-3459	398	23	stated	state	VERB
fnp-3459	398	24	.	.	PUNCT