id	sid	tid	token	lemma	pos
fnp-3500	1	1	65th	65th	ADJ
fnp-3500	1	2	annual	annual	ADJ
fnp-3500	1	3	meeting	meeting	NOUN
fnp-3500	1	4	of	of	ADP
fnp-3500	1	5	the	the	DET
fnp-3500	1	6	german	german	ADJ
fnp-3500	1	7	society	society	NOUN
fnp-3500	1	8	of	of	ADP
fnp-3500	1	9	neuropathology	neuropathology	NOUN
fnp-3500	1	10	and	and	CCONJ
fnp-3500	1	11	neuroanatomy	neuroanatomy	NOUN
fnp-3500	1	12	(	(	PUNCT
fnp-3500	1	13	dgnn	dgnn	NOUN
fnp-3500	1	14	)	)	PUNCT
fnp-3500	1	15	meeting	meeting	NOUN
fnp-3500	1	16	abstracts	abstract	NOUN
fnp-3500	1	17	feel	feel	VERB
fnp-3500	1	18	free	free	ADJ
fnp-3500	1	19	to	to	PART
fnp-3500	1	20	add	add	VERB
fnp-3500	1	21	comments	comment	NOUN
fnp-3500	1	22	by	by	ADP
fnp-3500	1	23	clicking	click	VERB
fnp-3500	1	24	these	these	DET
fnp-3500	1	25	icons	icon	NOUN
fnp-3500	1	26	on	on	ADP
fnp-3500	1	27	the	the	DET
fnp-3500	1	28	sidebar	sidebar	NOUN
fnp-3500	1	29	free	free	ADJ
fnp-3500	1	30	neuropathology	neuropathology	NOUN
fnp-3500	1	31	2:22	2:22	NUM
fnp-3500	1	32	(	(	PUNCT
fnp-3500	1	33	2021	2021	NUM
fnp-3500	1	34	)	)	PUNCT
fnp-3500	1	35	meeting	meeting	NOUN
fnp-3500	1	36	abstracts	abstract	VERB
fnp-3500	1	37	65th	65th	ADJ
fnp-3500	1	38	annual	annual	ADJ
fnp-3500	1	39	meeting	meeting	NOUN
fnp-3500	1	40	of	of	ADP
fnp-3500	1	41	the	the	DET
fnp-3500	1	42	german	german	ADJ
fnp-3500	1	43	society	society	NOUN
fnp-3500	1	44	of	of	ADP
fnp-3500	1	45	neuropathology	neuropathology	NOUN
fnp-3500	1	46	and	and	CCONJ
fnp-3500	1	47	neuroanatomy	neuroanatomy	NOUN
fnp-3500	1	48	(	(	PUNCT
fnp-3500	1	49	dgnn	dgnn	NOUN
fnp-3500	1	50	)	)	PUNCT
fnp-3500	1	51	meeting	meeting	NOUN
fnp-3500	1	52	abstracts	abstract	NOUN
fnp-3500	1	53	september	september	PROPN
fnp-3500	1	54	1–3	1–3	NUM
fnp-3500	1	55	,	,	PUNCT
fnp-3500	1	56	2021	2021	NUM
fnp-3500	1	57	submitted	submit	VERB
fnp-3500	1	58	:	:	PUNCT
fnp-3500	1	59	23	23	NUM
fnp-3500	1	60	august	august	PROPN
fnp-3500	1	61	2021	2021	NUM
fnp-3500	1	62	accepted	accept	VERB
fnp-3500	1	63	:	:	PUNCT
fnp-3500	1	64	23	23	NUM
fnp-3500	1	65	august	august	NOUN
fnp-3500	1	66	2021	2021	NUM
fnp-3500	1	67	published	publish	VERB
fnp-3500	1	68	:	:	PUNCT
fnp-3500	1	69	25	25	NUM
fnp-3500	1	70	august	august	PROPN
fnp-3500	1	71	2021	2021	NUM
fnp-3500	1	72	  	  	SPACE
fnp-3500	1	73	dear	dear	ADJ
fnp-3500	1	74	participants	participant	NOUN
fnp-3500	1	75	,	,	PUNCT
fnp-3500	1	76	dear	dear	ADJ
fnp-3500	1	77	colleagues	colleague	NOUN
fnp-3500	1	78	,	,	PUNCT
fnp-3500	1	79	it	it	PRON
fnp-3500	1	80	is	be	AUX
fnp-3500	1	81	our	our	PRON
fnp-3500	1	82	great	great	ADJ
fnp-3500	1	83	pleasure	pleasure	NOUN
fnp-3500	1	84	to	to	PART
fnp-3500	1	85	welcome	welcome	VERB
fnp-3500	1	86	you	you	PRON
fnp-3500	1	87	to	to	ADP
fnp-3500	1	88	the	the	DET
fnp-3500	1	89	65th	65th	ADJ
fnp-3500	1	90	annual	annual	ADJ
fnp-3500	1	91	meeting	meeting	NOUN
fnp-3500	1	92	of	of	ADP
fnp-3500	1	93	the	the	DET
fnp-3500	1	94	german	german	ADJ
fnp-3500	1	95	society	society	NOUN
fnp-3500	1	96	of	of	ADP
fnp-3500	1	97	neuropathology	neuropathology	NOUN
fnp-3500	1	98	and	and	CCONJ
fnp-3500	1	99	neuroanatomy	neuroanatomy	NOUN
fnp-3500	1	100	the	the	DET
fnp-3500	1	101	brain	brain	NOUN
fnp-3500	1	102	and	and	CCONJ
fnp-3500	1	103	nerve	nerve	NOUN
fnp-3500	1	104	microenvironment	microenvironment	NOUN
fnp-3500	1	105	in	in	ADP
fnp-3500	1	106	health	health	NOUN
fnp-3500	1	107	and	and	CCONJ
fnp-3500	1	108	disease	disease	NOUN
fnp-3500	1	109	which	which	PRON
fnp-3500	1	110	will	will	AUX
fnp-3500	1	111	be	be	AUX
fnp-3500	1	112	held	hold	VERB
fnp-3500	1	113	as	as	ADP
fnp-3500	1	114	a	a	DET
fnp-3500	1	115	virtual	virtual	ADJ
fnp-3500	1	116	meeting	meeting	NOUN
fnp-3500	1	117	from	from	ADP
fnp-3500	1	118	september	september	PROPN
fnp-3500	1	119	1–3	1–3	NUM
fnp-3500	1	120	,	,	PUNCT
fnp-3500	1	121	2021	2021	NUM
fnp-3500	1	122	.	.	PUNCT
fnp-3500	2	1	the	the	DET
fnp-3500	2	2	meeting	meeting	NOUN
fnp-3500	2	3	will	will	AUX
fnp-3500	2	4	bring	bring	VERB
fnp-3500	2	5	together	together	ADV
fnp-3500	2	6	basic	basic	ADJ
fnp-3500	2	7	and	and	CCONJ
fnp-3500	2	8	clinical	clinical	ADJ
fnp-3500	2	9	researchers	researcher	NOUN
fnp-3500	2	10	,	,	PUNCT
fnp-3500	2	11	physicians	physician	NOUN
fnp-3500	2	12	as	as	ADV
fnp-3500	2	13	well	well	ADV
fnp-3500	2	14	as	as	ADP
fnp-3500	2	15	junior	junior	ADJ
fnp-3500	2	16	scientists	scientist	NOUN
fnp-3500	2	17	and	and	CCONJ
fnp-3500	2	18	phd	phd	NOUN
fnp-3500	2	19	students	student	NOUN
fnp-3500	2	20	from	from	ADP
fnp-3500	2	21	different	different	ADJ
fnp-3500	2	22	disciplines	discipline	NOUN
fnp-3500	2	23	of	of	ADP
fnp-3500	2	24	basic	basic	ADJ
fnp-3500	2	25	and	and	CCONJ
fnp-3500	2	26	clinical	clinical	ADJ
fnp-3500	2	27	neuroscience	neuroscience	NOUN
fnp-3500	2	28	.	.	PUNCT
fnp-3500	3	1	we	we	PRON
fnp-3500	3	2	will	will	AUX
fnp-3500	3	3	have	have	VERB
fnp-3500	3	4	outstanding	outstanding	ADJ
fnp-3500	3	5	lectures	lecture	NOUN
fnp-3500	3	6	by	by	ADP
fnp-3500	3	7	and	and	CCONJ
fnp-3500	3	8	with	with	ADP
fnp-3500	3	9	some	some	PRON
fnp-3500	3	10	of	of	ADP
fnp-3500	3	11	the	the	DET
fnp-3500	3	12	most	most	ADV
fnp-3500	3	13	renowned	renowned	ADJ
fnp-3500	3	14	international	international	ADJ
fnp-3500	3	15	experts	expert	NOUN
fnp-3500	3	16	in	in	ADP
fnp-3500	3	17	the	the	DET
fnp-3500	3	18	field	field	NOUN
fnp-3500	3	19	of	of	ADP
fnp-3500	3	20	neuro	neuro	NOUN
fnp-3500	3	21	-	-	PUNCT
fnp-3500	3	22	oncology	oncology	NOUN
fnp-3500	3	23	,	,	PUNCT
fnp-3500	3	24	neuroinflammation	neuroinflammation	NOUN
fnp-3500	3	25	,	,	PUNCT
fnp-3500	3	26	neurodegeneration	neurodegeneration	NOUN
fnp-3500	3	27	and	and	CCONJ
fnp-3500	3	28	muscle	muscle	NOUN
fnp-3500	3	29	and	and	CCONJ
fnp-3500	3	30	nerve	nerve	NOUN
fnp-3500	3	31	diseases	disease	NOUN
fnp-3500	3	32	and	and	CCONJ
fnp-3500	3	33	look	look	VERB
fnp-3500	3	34	forward	forward	ADV
fnp-3500	3	35	to	to	ADP
fnp-3500	3	36	exciting	exciting	ADJ
fnp-3500	3	37	scientific	scientific	ADJ
fnp-3500	3	38	discussions	discussion	NOUN
fnp-3500	3	39	.	.	PUNCT
fnp-3500	4	1	there	there	PRON
fnp-3500	4	2	will	will	AUX
fnp-3500	4	3	also	also	ADV
fnp-3500	4	4	be	be	AUX
fnp-3500	4	5	a	a	DET
fnp-3500	4	6	special	special	ADJ
fnp-3500	4	7	and	and	CCONJ
fnp-3500	4	8	timely	timely	ADJ
fnp-3500	4	9	section	section	NOUN
fnp-3500	4	10	on	on	ADP
fnp-3500	4	11	the	the	DET
fnp-3500	4	12	effects	effect	NOUN
fnp-3500	4	13	of	of	ADP
fnp-3500	4	14	covid-19	covid-19	PROPN
fnp-3500	4	15	on	on	ADP
fnp-3500	4	16	the	the	DET
fnp-3500	4	17	central	central	ADJ
fnp-3500	4	18	and	and	CCONJ
fnp-3500	4	19	peripheral	peripheral	ADJ
fnp-3500	4	20	nervous	nervous	ADJ
fnp-3500	4	21	system	system	NOUN
fnp-3500	4	22	.	.	PUNCT
fnp-3500	5	1	the	the	DET
fnp-3500	5	2	three	three	NUM
fnp-3500	5	3	days	day	NOUN
fnp-3500	5	4	will	will	AUX
fnp-3500	5	5	offer	offer	VERB
fnp-3500	5	6	exciting	exciting	ADJ
fnp-3500	5	7	insights	insight	NOUN
fnp-3500	5	8	into	into	ADP
fnp-3500	5	9	different	different	ADJ
fnp-3500	5	10	areas	area	NOUN
fnp-3500	5	11	of	of	ADP
fnp-3500	5	12	basic	basic	ADJ
fnp-3500	5	13	and	and	CCONJ
fnp-3500	5	14	clinical	clinical	ADJ
fnp-3500	5	15	neuroscience	neuroscience	NOUN
fnp-3500	5	16	.	.	PUNCT
fnp-3500	6	1	we	we	PRON
fnp-3500	6	2	have	have	AUX
fnp-3500	6	3	also	also	ADV
fnp-3500	6	4	encouraged	encourage	VERB
fnp-3500	6	5	early	early	ADJ
fnp-3500	6	6	career	career	NOUN
fnp-3500	6	7	scientists	scientist	NOUN
fnp-3500	6	8	to	to	PART
fnp-3500	6	9	present	present	VERB
fnp-3500	6	10	their	their	PRON
fnp-3500	6	11	scientific	scientific	ADJ
fnp-3500	6	12	findings	finding	NOUN
fnp-3500	6	13	in	in	ADP
fnp-3500	6	14	short	short	ADJ
fnp-3500	6	15	talks	talk	NOUN
fnp-3500	6	16	and	and	CCONJ
fnp-3500	6	17	poster	poster	NOUN
fnp-3500	6	18	presentations	presentation	NOUN
fnp-3500	6	19	.	.	PUNCT
fnp-3500	7	1	we	we	PRON
fnp-3500	7	2	are	be	AUX
fnp-3500	7	3	therefore	therefore	ADV
fnp-3500	7	4	particularly	particularly	ADV
fnp-3500	7	5	thankful	thankful	ADJ
fnp-3500	7	6	that	that	SCONJ
fnp-3500	7	7	the	the	DET
fnp-3500	7	8	abstracts	abstract	NOUN
fnp-3500	7	9	of	of	ADP
fnp-3500	7	10	the	the	DET
fnp-3500	7	11	meeting	meeting	NOUN
fnp-3500	7	12	,	,	PUNCT
fnp-3500	7	13	which	which	PRON
fnp-3500	7	14	in	in	ADP
fnp-3500	7	15	their	their	PRON
fnp-3500	7	16	sum	sum	NOUN
fnp-3500	7	17	provide	provide	VERB
fnp-3500	7	18	the	the	DET
fnp-3500	7	19	best	good	ADJ
fnp-3500	7	20	overview	overview	NOUN
fnp-3500	7	21	of	of	ADP
fnp-3500	7	22	the	the	DET
fnp-3500	7	23	high	high	ADJ
fnp-3500	7	24	scientific	scientific	ADJ
fnp-3500	7	25	standing	standing	NOUN
fnp-3500	7	26	of	of	ADP
fnp-3500	7	27	the	the	DET
fnp-3500	7	28	field	field	NOUN
fnp-3500	7	29	,	,	PUNCT
fnp-3500	7	30	will	will	AUX
fnp-3500	7	31	be	be	AUX
fnp-3500	7	32	published	publish	VERB
fnp-3500	7	33	in	in	ADP
fnp-3500	7	34	free	free	ADJ
fnp-3500	7	35	neuropathology	neuropathology	NOUN
fnp-3500	7	36	.	.	PUNCT
fnp-3500	8	1	finally	finally	ADV
fnp-3500	8	2	,	,	PUNCT
fnp-3500	8	3	we	we	PRON
fnp-3500	8	4	would	would	AUX
fnp-3500	8	5	like	like	VERB
fnp-3500	8	6	to	to	PART
fnp-3500	8	7	thank	thank	VERB
fnp-3500	8	8	you	you	PRON
fnp-3500	8	9	all	all	PRON
fnp-3500	8	10	for	for	ADP
fnp-3500	8	11	your	your	PRON
fnp-3500	8	12	active	active	ADJ
fnp-3500	8	13	contribution	contribution	NOUN
fnp-3500	8	14	to	to	ADP
fnp-3500	8	15	this	this	DET
fnp-3500	8	16	conference	conference	NOUN
fnp-3500	8	17	in	in	ADP
fnp-3500	8	18	these	these	DET
fnp-3500	8	19	difficult	difficult	ADJ
fnp-3500	8	20	times	time	NOUN
fnp-3500	8	21	.	.	PUNCT
fnp-3500	9	1	we	we	PRON
fnp-3500	9	2	also	also	ADV
fnp-3500	9	3	thank	thank	VERB
fnp-3500	9	4	all	all	DET
fnp-3500	9	5	supporters	supporter	NOUN
fnp-3500	9	6	for	for	ADP
fnp-3500	9	7	their	their	PRON
fnp-3500	9	8	financial	financial	ADJ
fnp-3500	9	9	help	help	NOUN
fnp-3500	9	10	.	.	PUNCT
fnp-3500	10	1	we	we	PRON
fnp-3500	10	2	wish	wish	VERB
fnp-3500	10	3	you	you	PRON
fnp-3500	10	4	a	a	DET
fnp-3500	10	5	stimulating	stimulating	ADJ
fnp-3500	10	6	and	and	CCONJ
fnp-3500	10	7	exciting	exciting	ADJ
fnp-3500	10	8	conference	conference	NOUN
fnp-3500	10	9	.	.	PUNCT
fnp-3500	11	1	yours	yours	PRON
fnp-3500	11	2	sincerely	sincerely	ADV
fnp-3500	11	3	,	,	PUNCT
fnp-3500	11	4	prof	prof	PROPN
fnp-3500	11	5	.	.	PUNCT
fnp-3500	12	1	dr	dr	PROPN
fnp-3500	12	2	.	.	PROPN
fnp-3500	12	3	med	med	PROPN
fnp-3500	12	4	.	.	PUNCT
fnp-3500	13	1	till	till	SCONJ
fnp-3500	13	2	acker	acker	PROPN
fnp-3500	13	3	conference	conference	PROPN
fnp-3500	13	4	chair	chair	NOUN
fnp-3500	13	5	(	(	PUNCT
fnp-3500	13	6	justus	justus	PROPN
fnp-3500	13	7	liebig	liebig	PROPN
fnp-3500	13	8	university	university	PROPN
fnp-3500	13	9	giessen	giessen	VERB
fnp-3500	13	10	)	)	PUNCT
fnp-3500	13	11	pd	pd	PROPN
fnp-3500	13	12	.	.	PROPN
fnp-3500	13	13	dr	dr	PROPN
fnp-3500	13	14	.	.	PROPN
fnp-3500	13	15	med	med	PROPN
fnp-3500	13	16	.	.	PUNCT
fnp-3500	14	1	anne	anne	PROPN
fnp-3500	14	2	schänzer	schänzer	PROPN
fnp-3500	14	3	dr	dr	PROPN
fnp-3500	14	4	.	.	PROPN
fnp-3500	14	5	med	med	PROPN
fnp-3500	14	6	.	.	PUNCT
fnp-3500	15	1	hildegard	hildegard	PROPN
fnp-3500	15	2	dohmen	dohman	NOUN
fnp-3500	15	3	https://doi.org/10.17879/freeneuropathology-2021-3500	https://doi.org/10.17879/freeneuropathology-2021-3500	PROPN
fnp-3500	15	4	keywords	keyword	NOUN
fnp-3500	15	5	:	:	PUNCT
fnp-3500	15	6	german	german	ADJ
fnp-3500	15	7	society	society	NOUN
fnp-3500	15	8	for	for	ADP
fnp-3500	15	9	neuropathology	neuropathology	NOUN
fnp-3500	15	10	and	and	CCONJ
fnp-3500	15	11	neuroanatomy	neuroanatomy	NOUN
fnp-3500	15	12	,	,	PUNCT
fnp-3500	15	13	dgnn	dgnn	NOUN
fnp-3500	15	14	,	,	PUNCT
fnp-3500	15	15	meeting	meet	VERB
fnp-3500	15	16	abstracts	abstract	NOUN
fnp-3500	15	17	,	,	PUNCT
fnp-3500	15	18	65th	65th	ADJ
fnp-3500	15	19	meeting	meeting	NOUN
fnp-3500	15	20	sep	sep	PROPN
fnp-3500	15	21	.	.	PUNCT
fnp-3500	16	1	2021	2021	NUM
fnp-3500	16	2	contents	content	NOUN
fnp-3500	16	3	neuroinflammation	neuroinflammation	NOUN
fnp-3500	16	4	ni-01	ni-01	VERB
fnp-3500	16	5	ni-02	ni-02	VERB
fnp-3500	16	6	ni-03	ni-03	NUM
fnp-3500	16	7	neurooncology	neurooncology	NOUN
fnp-3500	16	8	adult	adult	NOUN
fnp-3500	17	1	i	i	PRON
fnp-3500	17	2	(	(	PUNCT
fnp-3500	17	3	from	from	ADP
fnp-3500	17	4	mechanisms	mechanism	NOUN
fnp-3500	17	5	to	to	ADP
fnp-3500	17	6	translation	translation	NOUN
fnp-3500	17	7	)	)	PUNCT
fnp-3500	17	8	noa-01	noa-01	ADP
fnp-3500	17	9	noa-02	noa-02	PROPN
fnp-3500	17	10	noa-03	noa-03	PROPN
fnp-3500	17	11	noa-04	noa-04	ADV
fnp-3500	17	12	noa-05	noa-05	PRON
fnp-3500	17	13	noa-06	noa-06	ADJ
fnp-3500	17	14	noa-07	noa-07	NUM
fnp-3500	17	15	muscle	muscle	NOUN
fnp-3500	17	16	&	&	CCONJ
fnp-3500	17	17	nerve	nerve	NOUN
fnp-3500	17	18	diseases	disease	NOUN
fnp-3500	17	19	mnd-01	mnd-01	VERB
fnp-3500	17	20	mnd-02	mnd-02	NOUN
fnp-3500	17	21	neurodegeneration	neurodegeneration	NOUN
fnp-3500	17	22	/	/	SYM
fnp-3500	17	23	covid-19	covid-19	PROPN
fnp-3500	17	24	and	and	CCONJ
fnp-3500	17	25	neuropathology	neuropathology	NOUN
fnp-3500	17	26	nd-01	nd-01	DET
fnp-3500	17	27	nd-02	nd-02	NOUN
fnp-3500	17	28	nd-03	nd-03	PART
fnp-3500	18	1	neurooncology	neurooncology	NOUN
fnp-3500	18	2	pediatrics	pediatric	NOUN
fnp-3500	18	3	nop-01	nop-01	ADJ
fnp-3500	18	4	nop-02	nop-02	NOUN
fnp-3500	18	5	postersession	postersession	NOUN
fnp-3500	18	6	i	i	PRON
fnp-3500	18	7	–	–	PUNCT
fnp-3500	18	8	neuroinflammation	neuroinflammation	NOUN
fnp-3500	18	9	pi-01	pi-01	NOUN
fnp-3500	18	10	pi-02	pi-02	NOUN
fnp-3500	18	11	pi-03	pi-03	NUM
fnp-3500	18	12	postersession	postersession	PROPN
fnp-3500	18	13	ii	ii	PROPN
fnp-3500	18	14	–	–	PUNCT
fnp-3500	18	15	neurooncology	neurooncology	NOUN
fnp-3500	18	16	pii-01	pii-01	PROPN
fnp-3500	18	17	pii-02	pii-02	NOUN
fnp-3500	18	18	pii-03	pii-03	NOUN
fnp-3500	18	19	poster	poster	NOUN
fnp-3500	18	20	session	session	NOUN
fnp-3500	18	21	iii	iii	X
fnp-3500	18	22	–	–	PUNCT
fnp-3500	18	23	muscle	muscle	NOUN
fnp-3500	18	24	&	&	CCONJ
fnp-3500	18	25	nerve	nerve	NOUN
fnp-3500	18	26	piii-01	piii-01	PROPN
fnp-3500	18	27	piii-02	piii-02	PROPN
fnp-3500	18	28	piii-03	piii-03	PROPN
fnp-3500	18	29	piii-04	piii-04	PROPN
fnp-3500	18	30	poster	poster	NOUN
fnp-3500	18	31	session	session	NOUN
fnp-3500	18	32	iv	iv	NUM
fnp-3500	18	33	–	–	PUNCT
fnp-3500	18	34	neurodegeneration	neurodegeneration	NOUN
fnp-3500	18	35	piv-01	piv-01	NUM
fnp-3500	18	36	piv-02	piv-02	ADP
fnp-3500	18	37	piv-03	piv-03	PROPN
fnp-3500	18	38	piv-04	piv-04	NOUN
fnp-3500	18	39	piv-05	piv-05	NOUN
fnp-3500	18	40	piv-06	piv-06	NOUN
fnp-3500	18	41	    	    	SPACE
fnp-3500	18	42	neuroinflammation	neuroinflammation	NOUN
fnp-3500	18	43	ni-01	ni-01	VERB
fnp-3500	18	44	free	free	ADJ
fnp-3500	18	45	neuropathol	neuropathol	NOUN
fnp-3500	18	46	2:22:4	2:22:4	NUM
fnp-3500	18	47	microbiota	microbiota	NOUN
fnp-3500	18	48	-	-	PUNCT
fnp-3500	18	49	derived	derive	VERB
fnp-3500	18	50	acetate	acetate	NOUN
fnp-3500	18	51	enables	enable	VERB
fnp-3500	18	52	the	the	DET
fnp-3500	18	53	metabolic	metabolic	NOUN
fnp-3500	18	54	fitness	fitness	NOUN
fnp-3500	18	55	of	of	ADP
fnp-3500	18	56	the	the	DET
fnp-3500	18	57	cns	cns	NOUN
fnp-3500	18	58	innate	innate	ADJ
fnp-3500	18	59	immune	immune	ADJ
fnp-3500	18	60	system	system	NOUN
fnp-3500	18	61	during	during	ADP
fnp-3500	18	62	health	health	NOUN
fnp-3500	18	63	and	and	CCONJ
fnp-3500	18	64	disease	disease	PROPN
fnp-3500	18	65	d.	d.	PROPN
fnp-3500	18	66	erny1	erny1	PROPN
fnp-3500	18	67	1	1	NUM
fnp-3500	19	1	institut	institut	PROPN
fnp-3500	19	2	für	für	PROPN
fnp-3500	19	3	neuropathologie	neuropathologie	PROPN
fnp-3500	19	4	,	,	PUNCT
fnp-3500	19	5	neurozentrum	neurozentrum	INTJ
fnp-3500	19	6	,	,	PUNCT
fnp-3500	19	7	freiburg	freiburg	PROPN
fnp-3500	19	8	i.	i.	PROPN
fnp-3500	19	9	br	br	PROPN
fnp-3500	19	10	.	.	PROPN
fnp-3500	19	11	,	,	PUNCT
fnp-3500	19	12	germany	germany	PROPN
fnp-3500	19	13	introduction	introduction	NOUN
fnp-3500	19	14	:	:	PUNCT
fnp-3500	19	15	as	as	ADP
fnp-3500	19	16	tissue	tissue	NOUN
fnp-3500	19	17	macrophages	macrophage	NOUN
fnp-3500	19	18	of	of	ADP
fnp-3500	19	19	the	the	DET
fnp-3500	19	20	central	central	ADJ
fnp-3500	19	21	nervous	nervous	ADJ
fnp-3500	19	22	system	system	NOUN
fnp-3500	19	23	(	(	PUNCT
fnp-3500	19	24	cns	cns	NOUN
fnp-3500	19	25	)	)	PUNCT
fnp-3500	19	26	microglia	microglia	NOUN
fnp-3500	19	27	constitute	constitute	VERB
fnp-3500	19	28	the	the	DET
fnp-3500	19	29	pivotal	pivotal	ADJ
fnp-3500	19	30	immune	immune	ADJ
fnp-3500	19	31	cells	cell	NOUN
fnp-3500	19	32	of	of	ADP
fnp-3500	19	33	this	this	DET
fnp-3500	19	34	organ	organ	NOUN
fnp-3500	19	35	.	.	PUNCT
fnp-3500	20	1	microglial	microglial	ADJ
fnp-3500	20	2	features	feature	NOUN
fnp-3500	20	3	are	be	AUX
fnp-3500	20	4	strongly	strongly	ADV
fnp-3500	20	5	dependent	dependent	ADJ
fnp-3500	20	6	on	on	ADP
fnp-3500	20	7	environmental	environmental	ADJ
fnp-3500	20	8	cues	cue	NOUN
fnp-3500	20	9	such	such	ADJ
fnp-3500	20	10	as	as	ADP
fnp-3500	20	11	commensal	commensal	ADJ
fnp-3500	20	12	microbiota	microbiota	NOUN
fnp-3500	20	13	.	.	PUNCT
fnp-3500	21	1	gut	gut	NOUN
fnp-3500	21	2	bacteria	bacteria	NOUN
fnp-3500	21	3	are	be	AUX
fnp-3500	21	4	known	know	VERB
fnp-3500	21	5	to	to	PART
fnp-3500	21	6	continuously	continuously	ADV
fnp-3500	21	7	modulate	modulate	VERB
fnp-3500	21	8	microglia	microglia	ADJ
fnp-3500	21	9	maturation	maturation	NOUN
fnp-3500	21	10	and	and	CCONJ
fnp-3500	21	11	function	function	NOUN
fnp-3500	21	12	by	by	ADP
fnp-3500	21	13	the	the	DET
fnp-3500	21	14	production	production	NOUN
fnp-3500	21	15	of	of	ADP
fnp-3500	21	16	short	short	ADJ
fnp-3500	21	17	-	-	PUNCT
fnp-3500	21	18	chain	chain	NOUN
fnp-3500	21	19	fatty	fatty	NOUN
fnp-3500	21	20	acids	acid	NOUN
fnp-3500	21	21	(	(	PUNCT
fnp-3500	21	22	scfa	scfa	NOUN
fnp-3500	21	23	)	)	PUNCT
fnp-3500	21	24	.	.	PUNCT
fnp-3500	22	1	however	however	ADV
fnp-3500	22	2	,	,	PUNCT
fnp-3500	22	3	the	the	DET
fnp-3500	22	4	precise	precise	ADJ
fnp-3500	22	5	mechanism	mechanism	NOUN
fnp-3500	22	6	of	of	ADP
fnp-3500	22	7	this	this	DET
fnp-3500	22	8	crosstalk	crosstalk	NOUN
fnp-3500	22	9	is	be	AUX
fnp-3500	22	10	unknown	unknown	ADJ
fnp-3500	22	11	.	.	PUNCT
fnp-3500	23	1	objectives	objective	NOUN
fnp-3500	23	2	&	&	CCONJ
fnp-3500	23	3	results	result	NOUN
fnp-3500	23	4	:	:	PUNCT
fnp-3500	23	5	here	here	ADV
fnp-3500	23	6	we	we	PRON
fnp-3500	23	7	determined	determine	VERB
fnp-3500	23	8	that	that	SCONJ
fnp-3500	23	9	the	the	DET
fnp-3500	23	10	immature	immature	ADJ
fnp-3500	23	11	phenotype	phenotype	NOUN
fnp-3500	23	12	of	of	ADP
fnp-3500	23	13	microglia	microglia	NOUN
fnp-3500	23	14	from	from	ADP
fnp-3500	23	15	germ	germ	NOUN
fnp-3500	23	16	-	-	PUNCT
fnp-3500	23	17	free	free	ADJ
fnp-3500	23	18	(	(	PUNCT
fnp-3500	23	19	gf	gf	NOUN
fnp-3500	23	20	)	)	PUNCT
fnp-3500	23	21	mice	mouse	NOUN
fnp-3500	23	22	is	be	AUX
fnp-3500	23	23	epigenetically	epigenetically	ADV
fnp-3500	23	24	imprinted	imprint	VERB
fnp-3500	23	25	by	by	ADP
fnp-3500	23	26	h3k4me3	h3k4me3	X
fnp-3500	23	27	and	and	CCONJ
fnp-3500	23	28	h3k9ac	h3k9ac	NOUN
fnp-3500	23	29	on	on	ADP
fnp-3500	23	30	metabolic	metabolic	NOUN
fnp-3500	23	31	genes	gene	NOUN
fnp-3500	23	32	associated	associate	VERB
fnp-3500	23	33	with	with	ADP
fnp-3500	23	34	substantial	substantial	ADJ
fnp-3500	23	35	functional	functional	ADJ
fnp-3500	23	36	alterations	alteration	NOUN
fnp-3500	23	37	including	include	VERB
fnp-3500	23	38	increased	increase	VERB
fnp-3500	23	39	mitochondrial	mitochondrial	ADJ
fnp-3500	23	40	mass	mass	NOUN
fnp-3500	23	41	and	and	CCONJ
fnp-3500	23	42	specific	specific	ADJ
fnp-3500	23	43	respiratory	respiratory	ADJ
fnp-3500	23	44	chain	chain	NOUN
fnp-3500	23	45	dysfunctions	dysfunction	NOUN
fnp-3500	23	46	.	.	PUNCT
fnp-3500	24	1	we	we	PRON
fnp-3500	24	2	identified	identify	VERB
fnp-3500	24	3	acetate	acetate	NOUN
fnp-3500	24	4	as	as	ADP
fnp-3500	24	5	the	the	DET
fnp-3500	24	6	essential	essential	ADJ
fnp-3500	24	7	microbiome	microbiome	NOUN
fnp-3500	24	8	-	-	PUNCT
fnp-3500	24	9	derived	derive	VERB
fnp-3500	24	10	scfa	scfa	NOUN
fnp-3500	24	11	driving	drive	VERB
fnp-3500	24	12	microglia	microglia	ADJ
fnp-3500	24	13	maturation	maturation	NOUN
fnp-3500	24	14	and	and	CCONJ
fnp-3500	24	15	regulating	regulate	VERB
fnp-3500	24	16	the	the	DET
fnp-3500	24	17	homeostatic	homeostatic	ADJ
fnp-3500	24	18	metabolic	metabolic	NOUN
fnp-3500	24	19	state	state	NOUN
fnp-3500	24	20	,	,	PUNCT
fnp-3500	24	21	and	and	CCONJ
fnp-3500	24	22	further	far	ADV
fnp-3500	24	23	showed	show	VERB
fnp-3500	24	24	that	that	SCONJ
fnp-3500	24	25	it	it	PRON
fnp-3500	24	26	is	be	AUX
fnp-3500	24	27	able	able	ADJ
fnp-3500	24	28	to	to	PART
fnp-3500	24	29	modulate	modulate	VERB
fnp-3500	24	30	microglial	microglial	ADJ
fnp-3500	24	31	phagocytosis	phagocytosis	NOUN
fnp-3500	24	32	and	and	CCONJ
fnp-3500	24	33	disease	disease	NOUN
fnp-3500	24	34	progression	progression	NOUN
fnp-3500	24	35	during	during	ADP
fnp-3500	24	36	neurodegeneration	neurodegeneration	NOUN
fnp-3500	24	37	.	.	PUNCT
fnp-3500	25	1	conclusion	conclusion	NOUN
fnp-3500	25	2	:	:	PUNCT
fnp-3500	25	3	these	these	DET
fnp-3500	25	4	findings	finding	NOUN
fnp-3500	25	5	indicate	indicate	VERB
fnp-3500	25	6	that	that	DET
fnp-3500	25	7	acetate	acetate	NOUN
fnp-3500	25	8	is	be	AUX
fnp-3500	25	9	an	an	DET
fnp-3500	25	10	essential	essential	ADJ
fnp-3500	25	11	bacteria	bacteria	NOUN
fnp-3500	25	12	-	-	PUNCT
fnp-3500	25	13	derived	derive	VERB
fnp-3500	25	14	molecule	molecule	NOUN
fnp-3500	25	15	driving	drive	VERB
fnp-3500	25	16	metabolic	metabolic	NOUN
fnp-3500	25	17	pathways	pathway	NOUN
fnp-3500	25	18	and	and	CCONJ
fnp-3500	25	19	functions	function	NOUN
fnp-3500	25	20	of	of	ADP
fnp-3500	25	21	microglia	microglia	NOUN
fnp-3500	25	22	during	during	ADP
fnp-3500	25	23	health	health	NOUN
fnp-3500	25	24	and	and	CCONJ
fnp-3500	25	25	perturbation	perturbation	NOUN
fnp-3500	25	26	.	.	PUNCT
fnp-3500	25	27	  	  	SPACE
fnp-3500	25	28	ni-02	ni-02	ADV
fnp-3500	25	29	free	free	ADJ
fnp-3500	25	30	neuropathol	neuropathol	NOUN
fnp-3500	25	31	2:22:5	2:22:5	NUM
fnp-3500	25	32	multiple	multiple	ADJ
fnp-3500	25	33	sclerosis	sclerosis	NOUN
fnp-3500	25	34	immunopathological	immunopathological	ADJ
fnp-3500	25	35	patterns	pattern	NOUN
fnp-3500	25	36	and	and	CCONJ
fnp-3500	25	37	their	their	PRON
fnp-3500	25	38	mri	mri	NOUN
fnp-3500	25	39	correlates	correlate	VERB
fnp-3500	25	40	i.	i.	PROPN
fnp-3500	25	41	metz1	metz1	PROPN
fnp-3500	25	42	,	,	PUNCT
fnp-3500	25	43	r.	r.	PROPN
fnp-3500	25	44	gavrilova2	gavrilova2	PROPN
fnp-3500	25	45	,	,	PUNCT
fnp-3500	25	46	s.	s.	PROPN
fnp-3500	25	47	weigand3	weigand3	PROPN
fnp-3500	25	48	,	,	PUNCT
fnp-3500	25	49	y.	y.	PROPN
fnp-3500	25	50	guo2	guo2	PROPN
fnp-3500	25	51	,	,	PUNCT
fnp-3500	25	52	n.	n.	PROPN
fnp-3500	25	53	zalewski2	zalewski2	PROPN
fnp-3500	25	54	,	,	PUNCT
fnp-3500	25	55	m.	m.	NOUN
fnp-3500	25	56	gloth1	gloth1	PROPN
fnp-3500	25	57	,	,	PUNCT
fnp-3500	25	58	o.	o.	PROPN
fnp-3500	25	59	tobin2	tobin2	PROPN
fnp-3500	25	60	,	,	PUNCT
fnp-3500	25	61	h.	h.	PROPN
fnp-3500	25	62	lassmann4	lassmann4	PROPN
fnp-3500	25	63	,	,	PUNCT
fnp-3500	26	1	j.	j.	PROPN
fnp-3500	26	2	tillema2	tillema2	PROPN
fnp-3500	26	3	,	,	PUNCT
fnp-3500	26	4	b.	b.	PROPN
fnp-3500	26	5	erickson2	erickson2	PROPN
fnp-3500	26	6	,	,	PUNCT
fnp-3500	26	7	j.	j.	PROPN
fnp-3500	26	8	parisi5	parisi5	PROPN
fnp-3500	26	9	,	,	PUNCT
fnp-3500	26	10	b.	b.	PROPN
fnp-3500	26	11	popescu6	popescu6	PROPN
fnp-3500	26	12	,	,	PUNCT
fnp-3500	26	13	s.	s.	PROPN
fnp-3500	26	14	becker7	becker7	PROPN
fnp-3500	26	15	,	,	PUNCT
fnp-3500	26	16	f.	f.	PROPN
fnp-3500	26	17	könig8	könig8	PROPN
fnp-3500	26	18	,	,	PUNCT
fnp-3500	26	19	j.	j.	PROPN
fnp-3500	26	20	frischer9	frischer9	PROPN
fnp-3500	26	21	,	,	PUNCT
fnp-3500	26	22	w.	w.	PROPN
fnp-3500	26	23	brück1	brück1	PROPN
fnp-3500	26	24	,	,	PUNCT
fnp-3500	26	25	c.	c.	PROPN
fnp-3500	26	26	lucchinetti2	lucchinetti2	PROPN
fnp-3500	26	27	1	1	NUM
fnp-3500	26	28	university	university	NOUN
fnp-3500	26	29	medical	medical	ADJ
fnp-3500	26	30	center	center	NOUN
fnp-3500	26	31	göttingen	göttingen	NOUN
fnp-3500	26	32	,	,	PUNCT
fnp-3500	26	33	georg	georg	NOUN
fnp-3500	26	34	-	-	PUNCT
fnp-3500	26	35	august	august	NOUN
fnp-3500	26	36	-	-	PUNCT
fnp-3500	26	37	university	university	NOUN
fnp-3500	26	38	,	,	PUNCT
fnp-3500	26	39	institute	institute	NOUN
fnp-3500	26	40	of	of	ADP
fnp-3500	26	41	neuropathology	neuropathology	NOUN
fnp-3500	26	42	,	,	PUNCT
fnp-3500	26	43	göttingen	göttingen	PROPN
fnp-3500	26	44	,	,	PUNCT
fnp-3500	26	45	germany	germany	PROPN
fnp-3500	26	46	2	2	NUM
fnp-3500	26	47	mayo	mayo	NOUN
fnp-3500	26	48	clinic	clinic	NOUN
fnp-3500	26	49	,	,	PUNCT
fnp-3500	26	50	department	department	NOUN
fnp-3500	26	51	of	of	ADP
fnp-3500	26	52	neurology	neurology	NOUN
fnp-3500	26	53	,	,	PUNCT
fnp-3500	26	54	rochester	rochester	PROPN
fnp-3500	26	55	,	,	PUNCT
fnp-3500	26	56	ny	ny	PROPN
fnp-3500	26	57	,	,	PUNCT
fnp-3500	26	58	united	united	PROPN
fnp-3500	26	59	states	states	PROPN
fnp-3500	26	60	3	3	NUM
fnp-3500	26	61	mayo	mayo	NOUN
fnp-3500	26	62	clinic	clinic	PROPN
fnp-3500	26	63	,	,	PUNCT
fnp-3500	26	64	department	department	PROPN
fnp-3500	26	65	of	of	ADP
fnp-3500	26	66	health	health	PROPN
fnp-3500	26	67	sciences	sciences	PROPN
fnp-3500	26	68	research	research	PROPN
fnp-3500	26	69	,	,	PUNCT
fnp-3500	26	70	rochester	rochester	PROPN
fnp-3500	26	71	,	,	PUNCT
fnp-3500	26	72	ny	ny	PROPN
fnp-3500	26	73	,	,	PUNCT
fnp-3500	26	74	united	united	PROPN
fnp-3500	26	75	states	states	PROPN
fnp-3500	26	76	4	4	NUM
fnp-3500	26	77	medical	medical	ADJ
fnp-3500	26	78	university	university	NOUN
fnp-3500	26	79	vienna	vienna	NOUN
fnp-3500	26	80	,	,	PUNCT
fnp-3500	26	81	department	department	NOUN
fnp-3500	26	82	of	of	ADP
fnp-3500	26	83	neuroimmunology	neuroimmunology	PROPN
fnp-3500	26	84	,	,	PUNCT
fnp-3500	26	85	center	center	NOUN
fnp-3500	26	86	for	for	ADP
fnp-3500	26	87	brain	brain	NOUN
fnp-3500	26	88	research	research	NOUN
fnp-3500	26	89	,	,	PUNCT
fnp-3500	26	90	vienna	vienna	PROPN
fnp-3500	26	91	,	,	PUNCT
fnp-3500	26	92	austria	austria	PROPN
fnp-3500	26	93	5	5	NUM
fnp-3500	26	94	mayo	mayo	NOUN
fnp-3500	26	95	clinic	clinic	NOUN
fnp-3500	26	96	,	,	PUNCT
fnp-3500	26	97	department	department	NOUN
fnp-3500	26	98	of	of	ADP
fnp-3500	26	99	laboratory	laboratory	NOUN
fnp-3500	26	100	medicine	medicine	NOUN
fnp-3500	26	101	and	and	CCONJ
fnp-3500	26	102	pathology	pathology	NOUN
fnp-3500	26	103	,	,	PUNCT
fnp-3500	26	104	rochester	rochester	PROPN
fnp-3500	26	105	,	,	PUNCT
fnp-3500	26	106	ny	ny	PROPN
fnp-3500	26	107	,	,	PUNCT
fnp-3500	26	108	united	united	PROPN
fnp-3500	26	109	states	states	PROPN
fnp-3500	26	110	6	6	NUM
fnp-3500	26	111	university	university	NOUN
fnp-3500	26	112	of	of	ADP
fnp-3500	26	113	saskatchewan	saskatchewan	PROPN
fnp-3500	26	114	,	,	PUNCT
fnp-3500	26	115	department	department	NOUN
fnp-3500	26	116	of	of	ADP
fnp-3500	26	117	anatomy	anatomy	PROPN
fnp-3500	26	118	,	,	PUNCT
fnp-3500	26	119	physiology	physiology	NOUN
fnp-3500	26	120	and	and	CCONJ
fnp-3500	26	121	pharmacology	pharmacology	NOUN
fnp-3500	26	122	,	,	PUNCT
fnp-3500	26	123	and	and	CCONJ
fnp-3500	26	124	cameco	cameco	PROPN
fnp-3500	26	125	ms	ms	PROPN
fnp-3500	26	126	neuroscience	neuroscience	PROPN
fnp-3500	26	127	research	research	NOUN
fnp-3500	26	128	center	center	NOUN
fnp-3500	26	129	,	,	PUNCT
fnp-3500	26	130	saskatchewan	saskatchewan	PROPN
fnp-3500	26	131	,	,	PUNCT
fnp-3500	26	132	canada	canada	PROPN
fnp-3500	26	133	7	7	NUM
fnp-3500	26	134	university	university	PROPN
fnp-3500	26	135	medical	medical	ADJ
fnp-3500	26	136	center	center	NOUN
fnp-3500	26	137	göttingen	göttingen	NOUN
fnp-3500	26	138	,	,	PUNCT
fnp-3500	26	139	department	department	NOUN
fnp-3500	26	140	of	of	ADP
fnp-3500	26	141	palliative	palliative	ADJ
fnp-3500	26	142	medicine	medicine	NOUN
fnp-3500	26	143	,	,	PUNCT
fnp-3500	26	144	göttingen	göttingen	NOUN
fnp-3500	26	145	,	,	PUNCT
fnp-3500	26	146	germany	germany	PROPN
fnp-3500	26	147	8	8	NUM
fnp-3500	26	148	klinikum	klinikum	PROPN
fnp-3500	26	149	kassel	kassel	PROPN
fnp-3500	26	150	,	,	PUNCT
fnp-3500	26	151	institute	institute	PROPN
fnp-3500	26	152	of	of	ADP
fnp-3500	26	153	pathology	pathology	PROPN
fnp-3500	26	154	,	,	PUNCT
fnp-3500	26	155	kassel	kassel	PROPN
fnp-3500	26	156	,	,	PUNCT
fnp-3500	26	157	germany	germany	PROPN
fnp-3500	26	158	9	9	NUM
fnp-3500	26	159	medical	medical	PROPN
fnp-3500	26	160	university	university	PROPN
fnp-3500	26	161	vienna	vienna	NOUN
fnp-3500	26	162	,	,	PUNCT
fnp-3500	26	163	department	department	NOUN
fnp-3500	26	164	of	of	ADP
fnp-3500	26	165	neurosurgery	neurosurgery	NOUN
fnp-3500	26	166	,	,	PUNCT
fnp-3500	26	167	vienna	vienna	PROPN
fnp-3500	26	168	,	,	PUNCT
fnp-3500	26	169	austria	austria	PROPN
fnp-3500	26	170	introduction	introduction	NOUN
fnp-3500	26	171	:	:	PUNCT
fnp-3500	26	172	early	early	ADJ
fnp-3500	26	173	active	active	ADJ
fnp-3500	26	174	multiple	multiple	ADJ
fnp-3500	26	175	sclerosis	sclerosis	NOUN
fnp-3500	26	176	lesions	lesion	NOUN
fnp-3500	26	177	can	can	AUX
fnp-3500	26	178	be	be	AUX
fnp-3500	26	179	classified	classify	VERB
fnp-3500	26	180	into	into	ADP
fnp-3500	26	181	three	three	NUM
fnp-3500	26	182	main	main	ADJ
fnp-3500	26	183	immunopathological	immunopathological	ADJ
fnp-3500	26	184	patterns	pattern	NOUN
fnp-3500	26	185	of	of	ADP
fnp-3500	26	186	active	active	ADJ
fnp-3500	26	187	demyelination	demyelination	NOUN
fnp-3500	26	188	(	(	PUNCT
fnp-3500	26	189	patterns	pattern	NOUN
fnp-3500	26	190	i	i	PROPN
fnp-3500	26	191	-	-	PUNCT
fnp-3500	26	192	iii	iii	NOUN
fnp-3500	26	193	)	)	PUNCT
fnp-3500	26	194	by	by	ADP
fnp-3500	26	195	histology	histology	NOUN
fnp-3500	26	196	.	.	PUNCT
fnp-3500	27	1	these	these	DET
fnp-3500	27	2	patterns	pattern	NOUN
fnp-3500	27	3	are	be	AUX
fnp-3500	27	4	inter	inter	ADJ
fnp-3500	27	5	-	-	ADJ
fnp-3500	27	6	individually	individually	ADV
fnp-3500	27	7	heterogeneous	heterogeneous	ADJ
fnp-3500	27	8	but	but	CCONJ
fnp-3500	27	9	intra	intra	ADJ
fnp-3500	27	10	-	-	ADJ
fnp-3500	27	11	individually	individually	ADV
fnp-3500	27	12	stable	stable	ADJ
fnp-3500	27	13	.	.	PUNCT
fnp-3500	28	1	in	in	ADP
fnp-3500	28	2	pattern	pattern	NOUN
fnp-3500	28	3	i	i	PRON
fnp-3500	28	4	and	and	CCONJ
fnp-3500	28	5	ii	ii	PROPN
fnp-3500	28	6	,	,	PUNCT
fnp-3500	28	7	a	a	DET
fnp-3500	28	8	t	t	NOUN
fnp-3500	28	9	-	-	PUNCT
fnp-3500	28	10	celland	celland	NOUN
fnp-3500	28	11	macrophage	macrophage	NOUN
fnp-3500	28	12	-	-	PUNCT
fnp-3500	28	13	associated	associate	VERB
fnp-3500	28	14	demyelination	demyelination	NOUN
fnp-3500	28	15	is	be	AUX
fnp-3500	28	16	suggested	suggest	VERB
fnp-3500	28	17	,	,	PUNCT
fnp-3500	28	18	with	with	ADP
fnp-3500	28	19	pattern	pattern	NOUN
fnp-3500	28	20	ii	ii	NOUN
fnp-3500	28	21	only	only	ADV
fnp-3500	28	22	showing	show	VERB
fnp-3500	28	23	signs	sign	NOUN
fnp-3500	28	24	of	of	ADP
fnp-3500	28	25	a	a	DET
fnp-3500	28	26	humoral	humoral	ADJ
fnp-3500	28	27	immune	immune	ADJ
fnp-3500	28	28	response	response	NOUN
fnp-3500	28	29	.	.	PUNCT
fnp-3500	29	1	pattern	pattern	NOUN
fnp-3500	29	2	iii	iii	NOUN
fnp-3500	29	3	is	be	AUX
fnp-3500	29	4	characterized	characterize	VERB
fnp-3500	29	5	by	by	ADP
fnp-3500	29	6	inflammatory	inflammatory	ADJ
fnp-3500	29	7	lesions	lesion	NOUN
fnp-3500	29	8	with	with	ADP
fnp-3500	29	9	an	an	DET
fnp-3500	29	10	oligodendrocyte	oligodendrocyte	ADJ
fnp-3500	29	11	degeneration	degeneration	NOUN
fnp-3500	29	12	.	.	PUNCT
fnp-3500	30	1	patterns	pattern	NOUN
fnp-3500	30	2	suggest	suggest	VERB
fnp-3500	30	3	pathogenic	pathogenic	ADJ
fnp-3500	30	4	heterogeneity	heterogeneity	NOUN
fnp-3500	30	5	,	,	PUNCT
fnp-3500	30	6	and	and	CCONJ
fnp-3500	30	7	we	we	PRON
fnp-3500	30	8	postulated	postulate	VERB
fnp-3500	30	9	that	that	SCONJ
fnp-3500	30	10	they	they	PRON
fnp-3500	30	11	have	have	VERB
fnp-3500	30	12	distinct	distinct	ADJ
fnp-3500	30	13	mri	mri	NOUN
fnp-3500	30	14	correlates	correlate	VERB
fnp-3500	30	15	that	that	PRON
fnp-3500	30	16	may	may	AUX
fnp-3500	30	17	serve	serve	VERB
fnp-3500	30	18	as	as	ADP
fnp-3500	30	19	biomarkers	biomarker	NOUN
fnp-3500	30	20	.	.	PUNCT
fnp-3500	31	1	objectives	objective	NOUN
fnp-3500	31	2	:	:	PUNCT
fnp-3500	31	3	to	to	PART
fnp-3500	31	4	analyze	analyze	VERB
fnp-3500	31	5	the	the	DET
fnp-3500	31	6	mri	mri	NOUN
fnp-3500	31	7	correlates	correlate	VERB
fnp-3500	31	8	of	of	ADP
fnp-3500	31	9	multiple	multiple	ADJ
fnp-3500	31	10	sclerosis	sclerosis	NOUN
fnp-3500	31	11	immunopathological	immunopathological	ADJ
fnp-3500	31	12	patterns	pattern	NOUN
fnp-3500	31	13	.	.	PUNCT
fnp-3500	32	1	patients	patient	NOUN
fnp-3500	32	2	and	and	CCONJ
fnp-3500	32	3	methods	method	NOUN
fnp-3500	32	4	:	:	PUNCT
fnp-3500	32	5	we	we	PRON
fnp-3500	32	6	evaluated	evaluate	VERB
fnp-3500	32	7	in	in	ADP
fnp-3500	32	8	an	an	DET
fnp-3500	32	9	international	international	ADJ
fnp-3500	32	10	collaborative	collaborative	ADJ
fnp-3500	32	11	retrospective	retrospective	ADJ
fnp-3500	32	12	cohort	cohort	NOUN
fnp-3500	32	13	study	study	VERB
fnp-3500	32	14	the	the	DET
fnp-3500	32	15	mri	mri	NOUN
fnp-3500	32	16	lesion	lesion	NOUN
fnp-3500	32	17	characteristics	characteristic	NOUN
fnp-3500	32	18	of	of	ADP
fnp-3500	32	19	789	789	NUM
fnp-3500	32	20	pre	pre	ADJ
fnp-3500	32	21	-	-	ADJ
fnp-3500	32	22	biopsy	biopsy	ADJ
fnp-3500	32	23	and	and	CCONJ
fnp-3500	32	24	follow	follow	VERB
fnp-3500	32	25	-	-	PUNCT
fnp-3500	32	26	up	up	ADP
fnp-3500	32	27	mris	mris	PROPN
fnp-3500	32	28	in	in	ADP
fnp-3500	32	29	relation	relation	NOUN
fnp-3500	32	30	to	to	ADP
fnp-3500	32	31	their	their	PRON
fnp-3500	32	32	histopathologically	histopathologically	ADV
fnp-3500	32	33	classified	classified	ADJ
fnp-3500	32	34	immunpathological	immunpathological	ADJ
fnp-3500	32	35	patterns	pattern	NOUN
fnp-3500	32	36	(	(	PUNCT
fnp-3500	32	37	n=161	n=161	ADJ
fnp-3500	32	38	subjects	subject	NOUN
fnp-3500	32	39	)	)	PUNCT
fnp-3500	32	40	and	and	CCONJ
fnp-3500	32	41	lesion	lesion	NOUN
fnp-3500	32	42	edge	edge	NOUN
fnp-3500	32	43	features	feature	NOUN
fnp-3500	32	44	(	(	PUNCT
fnp-3500	32	45	n=112	n=112	NOUN
fnp-3500	32	46	)	)	PUNCT
fnp-3500	32	47	.	.	PUNCT
fnp-3500	33	1	results	result	NOUN
fnp-3500	33	2	:	:	PUNCT
fnp-3500	33	3	a	a	DET
fnp-3500	33	4	strong	strong	ADJ
fnp-3500	33	5	association	association	NOUN
fnp-3500	33	6	of	of	ADP
fnp-3500	33	7	a	a	DET
fnp-3500	33	8	ring	ring	NOUN
fnp-3500	33	9	-	-	PUNCT
fnp-3500	33	10	like	like	ADJ
fnp-3500	33	11	enhancement	enhancement	NOUN
fnp-3500	33	12	and	and	CCONJ
fnp-3500	33	13	a	a	DET
fnp-3500	33	14	hypointense	hypointense	NOUN
fnp-3500	33	15	t2	t2	NOUN
fnp-3500	33	16	-	-	PUNCT
fnp-3500	33	17	weighted	weight	VERB
fnp-3500	33	18	rim	rim	NOUN
fnp-3500	33	19	(	(	PUNCT
fnp-3500	33	20	t2w	t2w	NOUN
fnp-3500	33	21	rim	rim	NOUN
fnp-3500	33	22	)	)	PUNCT
fnp-3500	33	23	with	with	ADP
fnp-3500	33	24	pattern	pattern	NOUN
fnp-3500	33	25	i	i	PRON
fnp-3500	33	26	and	and	CCONJ
fnp-3500	33	27	ii	ii	PROPN
fnp-3500	33	28	,	,	PUNCT
fnp-3500	33	29	but	but	CCONJ
fnp-3500	33	30	not	not	PART
fnp-3500	33	31	pattern	pattern	NOUN
fnp-3500	33	32	iii	iii	NOUN
fnp-3500	33	33	,	,	PUNCT
fnp-3500	33	34	was	be	AUX
fnp-3500	33	35	observed	observe	VERB
fnp-3500	33	36	.	.	PUNCT
fnp-3500	34	1	only	only	ADV
fnp-3500	34	2	a	a	DET
fnp-3500	34	3	fraction	fraction	NOUN
fnp-3500	34	4	of	of	ADP
fnp-3500	34	5	pattern	pattern	NOUN
fnp-3500	34	6	iii	iii	NUM
fnp-3500	34	7	patients	patient	NOUN
fnp-3500	34	8	showed	show	VERB
fnp-3500	34	9	a	a	DET
fnp-3500	34	10	ring	ring	NOUN
fnp-3500	34	11	-	-	PUNCT
fnp-3500	34	12	like	like	ADJ
fnp-3500	34	13	enhancement	enhancement	NOUN
fnp-3500	34	14	,	,	PUNCT
fnp-3500	34	15	and	and	CCONJ
fnp-3500	34	16	this	this	PRON
fnp-3500	34	17	was	be	AUX
fnp-3500	34	18	always	always	ADV
fnp-3500	34	19	atypical	atypical	ADJ
fnp-3500	34	20	.	.	PUNCT
fnp-3500	35	1	ring	ring	NOUN
fnp-3500	35	2	-	-	PUNCT
fnp-3500	35	3	like	like	ADJ
fnp-3500	35	4	enhancement	enhancement	NOUN
fnp-3500	35	5	and	and	CCONJ
fnp-3500	35	6	t2w	t2w	ADP
fnp-3500	35	7	rims	rim	NOUN
fnp-3500	35	8	colocalized	colocalize	VERB
fnp-3500	35	9	,	,	PUNCT
fnp-3500	35	10	and	and	CCONJ
fnp-3500	35	11	ring	ring	NOUN
fnp-3500	35	12	-	-	PUNCT
fnp-3500	35	13	like	like	ADJ
fnp-3500	35	14	enhancement	enhancement	NOUN
fnp-3500	35	15	showed	show	VERB
fnp-3500	35	16	a	a	DET
fnp-3500	35	17	strong	strong	ADJ
fnp-3500	35	18	association	association	NOUN
fnp-3500	35	19	with	with	ADP
fnp-3500	35	20	macrophage	macrophage	ADJ
fnp-3500	35	21	rims	rim	NOUN
fnp-3500	35	22	as	as	SCONJ
fnp-3500	35	23	shown	show	VERB
fnp-3500	35	24	by	by	ADP
fnp-3500	35	25	histology	histology	NOUN
fnp-3500	35	26	.	.	PUNCT
fnp-3500	36	1	a	a	DET
fnp-3500	36	2	strong	strong	ADJ
fnp-3500	36	3	concordance	concordance	NOUN
fnp-3500	36	4	of	of	ADP
fnp-3500	36	5	mri	mri	NOUN
fnp-3500	36	6	lesion	lesion	NOUN
fnp-3500	36	7	characteristics	characteristic	NOUN
fnp-3500	36	8	,	,	PUNCT
fnp-3500	36	9	meaning	mean	VERB
fnp-3500	36	10	that	that	SCONJ
fnp-3500	36	11	different	different	ADJ
fnp-3500	36	12	lesions	lesion	NOUN
fnp-3500	36	13	showed	show	VERB
fnp-3500	36	14	the	the	DET
fnp-3500	36	15	same	same	ADJ
fnp-3500	36	16	features	feature	NOUN
fnp-3500	36	17	,	,	PUNCT
fnp-3500	36	18	was	be	AUX
fnp-3500	36	19	found	find	VERB
fnp-3500	36	20	,	,	PUNCT
fnp-3500	36	21	indicating	indicate	VERB
fnp-3500	36	22	lesion	lesion	NOUN
fnp-3500	36	23	homogeneity	homogeneity	NOUN
fnp-3500	36	24	within	within	ADP
fnp-3500	36	25	individual	individual	ADJ
fnp-3500	36	26	patients	patient	NOUN
fnp-3500	36	27	.	.	PUNCT
fnp-3500	37	1	conclusion	conclusion	NOUN
fnp-3500	37	2	:	:	PUNCT
fnp-3500	37	3	we	we	PRON
fnp-3500	37	4	provide	provide	VERB
fnp-3500	37	5	robust	robust	ADJ
fnp-3500	37	6	evidence	evidence	NOUN
fnp-3500	37	7	that	that	SCONJ
fnp-3500	37	8	mri	mri	NOUN
fnp-3500	37	9	characteristics	characteristic	NOUN
fnp-3500	37	10	reflect	reflect	VERB
fnp-3500	37	11	specific	specific	ADJ
fnp-3500	37	12	histological	histological	ADJ
fnp-3500	37	13	features	feature	NOUN
fnp-3500	37	14	of	of	ADP
fnp-3500	37	15	ms	ms	NOUN
fnp-3500	37	16	immunopatterns	immunopattern	NOUN
fnp-3500	37	17	and	and	CCONJ
fnp-3500	37	18	that	that	SCONJ
fnp-3500	37	19	ring	ring	NOUN
fnp-3500	37	20	-	-	PUNCT
fnp-3500	37	21	like	like	ADJ
fnp-3500	37	22	enhancement	enhancement	NOUN
fnp-3500	37	23	and	and	CCONJ
fnp-3500	37	24	t2w	t2w	ADP
fnp-3500	37	25	hypointense	hypointense	NOUN
fnp-3500	37	26	rims	rim	NOUN
fnp-3500	37	27	might	might	AUX
fnp-3500	37	28	serve	serve	VERB
fnp-3500	37	29	as	as	ADP
fnp-3500	37	30	a	a	DET
fnp-3500	37	31	valuable	valuable	ADJ
fnp-3500	37	32	non	non	ADJ
fnp-3500	37	33	-	-	ADJ
fnp-3500	37	34	invasive	invasive	ADJ
fnp-3500	37	35	biomarker	biomarker	NOUN
fnp-3500	37	36	to	to	PART
fnp-3500	37	37	differentiate	differentiate	VERB
fnp-3500	37	38	pathological	pathological	ADJ
fnp-3500	37	39	patterns	pattern	NOUN
fnp-3500	37	40	of	of	ADP
fnp-3500	37	41	demyelination	demyelination	NOUN
fnp-3500	37	42	.	.	PUNCT
fnp-3500	37	43	  	  	SPACE
fnp-3500	38	1	ni-03	ni-03	CCONJ
fnp-3500	38	2	free	free	ADJ
fnp-3500	38	3	neuropathol	neuropathol	NOUN
fnp-3500	38	4	2:22:7	2:22:7	NUM
fnp-3500	38	5	microvascular	microvascular	ADJ
fnp-3500	38	6	vulnerability	vulnerability	NOUN
fnp-3500	38	7	to	to	PART
fnp-3500	38	8	cytokine	cytokine	VERB
fnp-3500	38	9	toxicity	toxicity	NOUN
fnp-3500	38	10	is	be	AUX
fnp-3500	38	11	a	a	DET
fnp-3500	38	12	critical	critical	ADJ
fnp-3500	38	13	initiating	initiate	VERB
fnp-3500	38	14	factor	factor	NOUN
fnp-3500	38	15	in	in	ADP
fnp-3500	38	16	cerebral	cerebral	ADJ
fnp-3500	38	17	interferonopathies	interferonopathies	PROPN
fnp-3500	38	18	b.	b.	PROPN
fnp-3500	38	19	viengkhou1	viengkhou1	PROPN
fnp-3500	38	20	,	,	PUNCT
fnp-3500	38	21	e.	e.	PROPN
fnp-3500	38	22	hayashida1	hayashida1	PROPN
fnp-3500	38	23	,	,	PUNCT
fnp-3500	38	24	s.	s.	PROPN
fnp-3500	38	25	mcglasson2	mcglasson2	PROPN
fnp-3500	38	26	,	,	PUNCT
fnp-3500	38	27	k.	k.	PROPN
fnp-3500	38	28	emelianova2	emelianova2	PROPN
fnp-3500	38	29	,	,	PUNCT
fnp-3500	38	30	y.	y.	PROPN
fnp-3500	38	31	crow2	crow2	PROPN
fnp-3500	38	32	,	,	PUNCT
fnp-3500	38	33	a.	a.	PROPN
fnp-3500	38	34	pagenstecher3	pagenstecher3	PROPN
fnp-3500	38	35	,	,	PUNCT
fnp-3500	38	36	d.	d.	PROPN
fnp-3500	38	37	hunt2	hunt2	PROPN
fnp-3500	38	38	,	,	PUNCT
fnp-3500	38	39	m.	m.	NOUN
fnp-3500	38	40	hofer1	hofer1	NOUN
fnp-3500	38	41	1	1	NUM
fnp-3500	38	42	the	the	DET
fnp-3500	38	43	university	university	PROPN
fnp-3500	38	44	of	of	ADP
fnp-3500	38	45	sydney	sydney	PROPN
fnp-3500	38	46	,	,	PUNCT
fnp-3500	38	47	charles	charles	PROPN
fnp-3500	38	48	perkins	perkins	PROPN
fnp-3500	38	49	centre	centre	PROPN
fnp-3500	38	50	,	,	PUNCT
fnp-3500	38	51	sydney	sydney	PROPN
fnp-3500	38	52	,	,	PUNCT
fnp-3500	38	53	australia	australia	PROPN
fnp-3500	38	54	2	2	NUM
fnp-3500	38	55	the	the	DET
fnp-3500	38	56	university	university	PROPN
fnp-3500	38	57	of	of	ADP
fnp-3500	38	58	edinburgh	edinburgh	PROPN
fnp-3500	38	59	,	,	PUNCT
fnp-3500	38	60	edinburgh	edinburgh	PROPN
fnp-3500	38	61	,	,	PUNCT
fnp-3500	38	62	united	united	PROPN
fnp-3500	38	63	kingdom	kingdom	PROPN
fnp-3500	38	64	3	3	PROPN
fnp-3500	38	65	university	university	PROPN
fnp-3500	38	66	of	of	ADP
fnp-3500	38	67	marburg	marburg	PROPN
fnp-3500	38	68	,	,	PUNCT
fnp-3500	38	69	dept	dept	NOUN
fnp-3500	39	1	.	.	PUNCT
fnp-3500	39	2	neuropathology	neuropathology	PROPN
fnp-3500	39	3	,	,	PUNCT
fnp-3500	39	4	marburg	marburg	PROPN
fnp-3500	39	5	,	,	PUNCT
fnp-3500	39	6	germany	germany	PROPN
fnp-3500	39	7	cerebral	cerebral	ADJ
fnp-3500	39	8	interferonopathies	interferonopathie	NOUN
fnp-3500	39	9	are	be	AUX
fnp-3500	39	10	a	a	DET
fnp-3500	39	11	group	group	NOUN
fnp-3500	39	12	of	of	ADP
fnp-3500	39	13	devastating	devastating	ADJ
fnp-3500	39	14	diseases	disease	NOUN
fnp-3500	39	15	characterised	characterise	VERB
fnp-3500	39	16	by	by	ADP
fnp-3500	39	17	overproduction	overproduction	NOUN
fnp-3500	39	18	of	of	ADP
fnp-3500	39	19	interferon	interferon	ADJ
fnp-3500	39	20	-	-	PUNCT
fnp-3500	39	21	alpha	alpha	NOUN
fnp-3500	39	22	(	(	PUNCT
fnp-3500	39	23	ifn	ifn	PROPN
fnp-3500	39	24	-	-	PUNCT
fnp-3500	39	25	α	α	NOUN
fnp-3500	39	26	)	)	PUNCT
fnp-3500	39	27	,	,	PUNCT
fnp-3500	39	28	leading	lead	VERB
fnp-3500	39	29	to	to	ADP
fnp-3500	39	30	diffuse	diffuse	VERB
fnp-3500	39	31	brain	brain	NOUN
fnp-3500	39	32	damage	damage	NOUN
fnp-3500	39	33	.	.	PUNCT
fnp-3500	40	1	importantly	importantly	ADV
fnp-3500	40	2	,	,	PUNCT
fnp-3500	40	3	the	the	DET
fnp-3500	40	4	critical	critical	ADJ
fnp-3500	40	5	cellular	cellular	ADJ
fnp-3500	40	6	mediators	mediator	NOUN
fnp-3500	40	7	of	of	ADP
fnp-3500	40	8	ifn	ifn	PROPN
fnp-3500	40	9	-	-	PUNCT
fnp-3500	40	10	α	α	NOUN
fnp-3500	40	11	are	be	AUX
fnp-3500	40	12	unknown	unknown	ADJ
fnp-3500	40	13	.	.	PUNCT
fnp-3500	41	1	here	here	ADV
fnp-3500	41	2	we	we	PRON
fnp-3500	41	3	use	use	VERB
fnp-3500	41	4	a	a	DET
fnp-3500	41	5	mouse	mouse	NOUN
fnp-3500	41	6	model	model	NOUN
fnp-3500	41	7	of	of	ADP
fnp-3500	41	8	brain	brain	NOUN
fnp-3500	41	9	-	-	PUNCT
fnp-3500	41	10	targeted	target	VERB
fnp-3500	41	11	ifn	ifn	PROPN
fnp-3500	41	12	-	-	PUNCT
fnp-3500	41	13	α	α	NOUN
fnp-3500	41	14	production	production	NOUN
fnp-3500	41	15	to	to	PART
fnp-3500	41	16	identify	identify	VERB
fnp-3500	41	17	endothelial	endothelial	ADJ
fnp-3500	41	18	cells	cell	NOUN
fnp-3500	41	19	as	as	ADP
fnp-3500	41	20	the	the	DET
fnp-3500	41	21	major	major	ADJ
fnp-3500	41	22	mediator	mediator	NOUN
fnp-3500	41	23	of	of	ADP
fnp-3500	41	24	ifn	ifn	PROPN
fnp-3500	41	25	-	-	PUNCT
fnp-3500	41	26	α	α	NOUN
fnp-3500	41	27	neurotoxicity	neurotoxicity	NOUN
fnp-3500	41	28	.	.	PUNCT
fnp-3500	42	1	specifically	specifically	ADV
fnp-3500	42	2	,	,	PUNCT
fnp-3500	42	3	we	we	PRON
fnp-3500	42	4	have	have	AUX
fnp-3500	42	5	created	create	VERB
fnp-3500	42	6	a	a	DET
fnp-3500	42	7	single	single	ADJ
fnp-3500	42	8	cell	cell	NOUN
fnp-3500	42	9	atlas	atlas	PROPN
fnp-3500	42	10	of	of	ADP
fnp-3500	42	11	the	the	DET
fnp-3500	42	12	"	"	PUNCT
fnp-3500	42	13	cerebral	cerebral	ADJ
fnp-3500	42	14	interferome	interferome	ADJ
fnp-3500	42	15	"	"	PUNCT
fnp-3500	42	16	using	use	VERB
fnp-3500	42	17	single	single	ADJ
fnp-3500	42	18	cell	cell	NOUN
fnp-3500	42	19	rna	rna	NOUN
fnp-3500	42	20	sequencing	sequencing	NOUN
fnp-3500	42	21	of	of	ADP
fnp-3500	42	22	brain	brain	NOUN
fnp-3500	42	23	cells	cell	NOUN
fnp-3500	42	24	of	of	ADP
fnp-3500	42	25	wild	wild	ADJ
fnp-3500	42	26	type	type	NOUN
fnp-3500	42	27	and	and	CCONJ
fnp-3500	42	28	ifn	ifn	PROPN
fnp-3500	42	29	-	-	PUNCT
fnp-3500	42	30	α	α	NOUN
fnp-3500	42	31	transgenic	transgenic	NOUN
fnp-3500	42	32	mice	mouse	NOUN
fnp-3500	42	33	.	.	PUNCT
fnp-3500	43	1	by	by	ADP
fnp-3500	43	2	linking	link	VERB
fnp-3500	43	3	this	this	DET
fnp-3500	43	4	dataset	dataset	NOUN
fnp-3500	43	5	with	with	ADP
fnp-3500	43	6	neuropathological	neuropathological	ADJ
fnp-3500	43	7	studies	study	NOUN
fnp-3500	43	8	of	of	ADP
fnp-3500	43	9	cerebral	cerebral	ADJ
fnp-3500	43	10	interferon	interferon	ADJ
fnp-3500	43	11	overproduction	overproduction	NOUN
fnp-3500	43	12	,	,	PUNCT
fnp-3500	43	13	we	we	PRON
fnp-3500	43	14	identified	identify	VERB
fnp-3500	43	15	a	a	DET
fnp-3500	43	16	role	role	NOUN
fnp-3500	43	17	for	for	ADP
fnp-3500	43	18	cerebral	cerebral	ADJ
fnp-3500	43	19	endothelial	endothelial	ADJ
fnp-3500	43	20	cells	cell	NOUN
fnp-3500	43	21	in	in	ADP
fnp-3500	43	22	the	the	DET
fnp-3500	43	23	initiation	initiation	NOUN
fnp-3500	43	24	of	of	ADP
fnp-3500	43	25	brain	brain	NOUN
fnp-3500	43	26	disease	disease	NOUN
fnp-3500	43	27	.	.	PUNCT
fnp-3500	44	1	we	we	PRON
fnp-3500	44	2	then	then	ADV
fnp-3500	44	3	confirmed	confirm	VERB
fnp-3500	44	4	a	a	DET
fnp-3500	44	5	critical	critical	ADJ
fnp-3500	44	6	role	role	NOUN
fnp-3500	44	7	for	for	ADP
fnp-3500	44	8	endothelial	endothelial	ADJ
fnp-3500	44	9	interferon	interferon	NOUN
fnp-3500	44	10	signalling	signal	VERB
fnp-3500	44	11	through	through	ADP
fnp-3500	44	12	targeted	target	VERB
fnp-3500	44	13	deletion	deletion	NOUN
fnp-3500	44	14	of	of	ADP
fnp-3500	44	15	the	the	DET
fnp-3500	44	16	type	type	NOUN
fnp-3500	44	17	i	i	PRON
fnp-3500	44	18	interferon	interferon	ADJ
fnp-3500	44	19	receptor	receptor	NOUN
fnp-3500	44	20	ifnar	ifnar	PROPN
fnp-3500	44	21	on	on	ADP
fnp-3500	44	22	endothelial	endothelial	ADJ
fnp-3500	44	23	cells	cell	NOUN
fnp-3500	44	24	of	of	ADP
fnp-3500	44	25	the	the	DET
fnp-3500	44	26	transgenic	transgenic	NOUN
fnp-3500	44	27	mice	mouse	NOUN
fnp-3500	44	28	.	.	PUNCT
fnp-3500	45	1	remarkably	remarkably	ADV
fnp-3500	45	2	,	,	PUNCT
fnp-3500	45	3	this	this	DET
fnp-3500	45	4	intervention	intervention	NOUN
fnp-3500	45	5	led	lead	VERB
fnp-3500	45	6	to	to	ADP
fnp-3500	45	7	near	near	ADV
fnp-3500	45	8	-	-	PUNCT
fnp-3500	45	9	complete	complete	ADJ
fnp-3500	45	10	rescue	rescue	NOUN
fnp-3500	45	11	of	of	ADP
fnp-3500	45	12	the	the	DET
fnp-3500	45	13	complex	complex	ADJ
fnp-3500	45	14	multicellular	multicellular	ADJ
fnp-3500	45	15	disease	disease	NOUN
fnp-3500	45	16	phenotype	phenotype	NOUN
fnp-3500	45	17	.	.	PUNCT
fnp-3500	46	1	importantly	importantly	ADV
fnp-3500	46	2	,	,	PUNCT
fnp-3500	46	3	we	we	PRON
fnp-3500	46	4	show	show	VERB
fnp-3500	46	5	that	that	SCONJ
fnp-3500	46	6	diffuse	diffuse	PROPN
fnp-3500	46	7	aspects	aspect	NOUN
fnp-3500	46	8	of	of	ADP
fnp-3500	46	9	interferonopathic	interferonopathic	ADJ
fnp-3500	46	10	brain	brain	NOUN
fnp-3500	46	11	disease	disease	NOUN
fnp-3500	46	12	such	such	ADJ
fnp-3500	46	13	as	as	ADP
fnp-3500	46	14	calcification	calcification	NOUN
fnp-3500	46	15	and	and	CCONJ
fnp-3500	46	16	neuronal	neuronal	ADJ
fnp-3500	46	17	loss	loss	NOUN
fnp-3500	46	18	arise	arise	NOUN
fnp-3500	46	19	as	as	ADP
fnp-3500	46	20	a	a	DET
fnp-3500	46	21	downstream	downstream	ADJ
fnp-3500	46	22	consequence	consequence	NOUN
fnp-3500	46	23	of	of	ADP
fnp-3500	46	24	cytokine	cytokine	NOUN
fnp-3500	46	25	-	-	PUNCT
fnp-3500	46	26	induced	induce	VERB
fnp-3500	46	27	microvascular	microvascular	NOUN
fnp-3500	46	28	disease	disease	NOUN
fnp-3500	46	29	.	.	PUNCT
fnp-3500	47	1	in	in	ADP
fnp-3500	47	2	conclusion	conclusion	NOUN
fnp-3500	47	3	,	,	PUNCT
fnp-3500	47	4	our	our	PRON
fnp-3500	47	5	data	datum	NOUN
fnp-3500	47	6	identify	identify	VERB
fnp-3500	47	7	damage	damage	NOUN
fnp-3500	47	8	to	to	ADP
fnp-3500	47	9	the	the	DET
fnp-3500	47	10	cerebral	cerebral	ADJ
fnp-3500	47	11	microvasculature	microvasculature	NOUN
fnp-3500	47	12	as	as	ADP
fnp-3500	47	13	the	the	DET
fnp-3500	47	14	critical	critical	ADJ
fnp-3500	47	15	first	first	ADJ
fnp-3500	47	16	step	step	NOUN
fnp-3500	47	17	in	in	ADP
fnp-3500	47	18	interferon	interferon	ADJ
fnp-3500	47	19	neurotoxicity	neurotoxicity	NOUN
fnp-3500	47	20	,	,	PUNCT
fnp-3500	47	21	and	and	CCONJ
fnp-3500	47	22	pinpoint	pinpoint	NOUN
fnp-3500	47	23	ifnar	ifnar	PROPN
fnp-3500	47	24	signalling	signal	VERB
fnp-3500	47	25	within	within	ADP
fnp-3500	47	26	endothelial	endothelial	ADJ
fnp-3500	47	27	cells	cell	NOUN
fnp-3500	47	28	as	as	ADP
fnp-3500	47	29	a	a	DET
fnp-3500	47	30	key	key	ADJ
fnp-3500	47	31	site	site	NOUN
fnp-3500	47	32	for	for	ADP
fnp-3500	47	33	potential	potential	ADJ
fnp-3500	47	34	therapeutic	therapeutic	ADJ
fnp-3500	47	35	intervention	intervention	NOUN
fnp-3500	47	36	.	.	PUNCT
fnp-3500	47	37	  	  	SPACE
fnp-3500	48	1	neurooncology	neurooncology	NOUN
fnp-3500	48	2	adult	adult	NOUN
fnp-3500	48	3	i	i	PRON
fnp-3500	48	4	(	(	PUNCT
fnp-3500	48	5	from	from	ADP
fnp-3500	48	6	mechanisms	mechanism	NOUN
fnp-3500	48	7	to	to	ADP
fnp-3500	48	8	translation	translation	NOUN
fnp-3500	48	9	)	)	PUNCT
fnp-3500	48	10	noa-01	noa-01	VERB
fnp-3500	48	11	free	free	ADJ
fnp-3500	48	12	neuropathol	neuropathol	NOUN
fnp-3500	48	13	2:22:8	2:22:8	NUM
fnp-3500	48	14	molecular	molecular	ADJ
fnp-3500	48	15	mechanism	mechanism	NOUN
fnp-3500	48	16	of	of	ADP
fnp-3500	48	17	therapy	therapy	NOUN
fnp-3500	48	18	resistance	resistance	NOUN
fnp-3500	48	19	in	in	ADP
fnp-3500	48	20	malignant	malignant	ADJ
fnp-3500	48	21	melanoma	melanoma	NOUN
fnp-3500	48	22	brain	brain	NOUN
fnp-3500	48	23	metastasis	metastasis	NOUN
fnp-3500	48	24	e.	e.	PROPN
fnp-3500	48	25	schumann1	schumann1	PROPN
fnp-3500	48	26	,	,	PUNCT
fnp-3500	48	27	r.	r.	PROPN
fnp-3500	48	28	koll1	koll1	PROPN
fnp-3500	48	29	,	,	PUNCT
fnp-3500	48	30	j.	j.	PROPN
fnp-3500	48	31	onken2	onken2	PROPN
fnp-3500	48	32	,	,	PUNCT
fnp-3500	48	33	k.	k.	PROPN
fnp-3500	48	34	jürchott3	jürchott3	PROPN
fnp-3500	48	35	,	,	PUNCT
fnp-3500	48	36	t.	t.	PROPN
fnp-3500	48	37	redmer4	redmer4	PROPN
fnp-3500	48	38	,	,	PUNCT
fnp-3500	48	39	j.	j.	PROPN
fnp-3500	48	40	radke1	radke1	PROPN
fnp-3500	48	41	1	1	NUM
fnp-3500	48	42	charité	charité	PROPN
fnp-3500	48	43	–	–	PUNCT
fnp-3500	48	44	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	48	45	berlin	berlin	PROPN
fnp-3500	48	46	,	,	PUNCT
fnp-3500	48	47	department	department	NOUN
fnp-3500	48	48	of	of	ADP
fnp-3500	48	49	neuropathology	neuropathology	NOUN
fnp-3500	48	50	,	,	PUNCT
fnp-3500	48	51	berlin	berlin	PROPN
fnp-3500	48	52	,	,	PUNCT
fnp-3500	48	53	germany	germany	PROPN
fnp-3500	48	54	2	2	NUM
fnp-3500	48	55	charité	charité	PROPN
fnp-3500	48	56	–	–	PUNCT
fnp-3500	48	57	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	48	58	berlin	berlin	PROPN
fnp-3500	48	59	,	,	PUNCT
fnp-3500	48	60	department	department	NOUN
fnp-3500	48	61	of	of	ADP
fnp-3500	48	62	neurosurgery	neurosurgery	NOUN
fnp-3500	48	63	,	,	PUNCT
fnp-3500	48	64	berlin	berlin	PROPN
fnp-3500	48	65	,	,	PUNCT
fnp-3500	48	66	germany	germany	PROPN
fnp-3500	48	67	3	3	NUM
fnp-3500	48	68	charité	charité	PROPN
fnp-3500	48	69	–	–	PUNCT
fnp-3500	48	70	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	48	71	berlin	berlin	PROPN
fnp-3500	48	72	,	,	PUNCT
fnp-3500	48	73	institute	institute	PROPN
fnp-3500	48	74	of	of	ADP
fnp-3500	48	75	medical	medical	ADJ
fnp-3500	48	76	immunology	immunology	NOUN
fnp-3500	48	77	,	,	PUNCT
fnp-3500	48	78	berlin	berlin	PROPN
fnp-3500	48	79	,	,	PUNCT
fnp-3500	48	80	germany	germany	PROPN
fnp-3500	48	81	4	4	NUM
fnp-3500	48	82	university	university	NOUN
fnp-3500	48	83	of	of	ADP
fnp-3500	48	84	veterinary	veterinary	ADJ
fnp-3500	48	85	medicine	medicine	NOUN
fnp-3500	48	86	vienna	vienna	PROPN
fnp-3500	48	87	,	,	PUNCT
fnp-3500	48	88	department	department	NOUN
fnp-3500	48	89	of	of	ADP
fnp-3500	48	90	medical	medical	ADJ
fnp-3500	48	91	biochemistry	biochemistry	PROPN
fnp-3500	48	92	,	,	PUNCT
fnp-3500	48	93	vienna	vienna	PROPN
fnp-3500	48	94	,	,	PUNCT
fnp-3500	48	95	austria	austria	PROPN
fnp-3500	48	96	introduction	introduction	NOUN
fnp-3500	48	97	:	:	PUNCT
fnp-3500	48	98	malignant	malignant	ADJ
fnp-3500	48	99	melanoma	melanoma	NOUN
fnp-3500	48	100	(	(	PUNCT
fnp-3500	48	101	mm	mm	NOUN
fnp-3500	48	102	)	)	PUNCT
fnp-3500	48	103	has	have	VERB
fnp-3500	48	104	the	the	DET
fnp-3500	48	105	highest	high	ADJ
fnp-3500	48	106	potential	potential	NOUN
fnp-3500	48	107	to	to	PART
fnp-3500	48	108	disseminate	disseminate	VERB
fnp-3500	48	109	to	to	ADP
fnp-3500	48	110	the	the	DET
fnp-3500	48	111	cns	cns	NOUN
fnp-3500	48	112	.	.	PUNCT
fnp-3500	49	1	about	about	ADV
fnp-3500	49	2	45	45	NUM
fnp-3500	49	3	%	%	NOUN
fnp-3500	49	4	of	of	ADP
fnp-3500	49	5	patients	patient	NOUN
fnp-3500	49	6	suffer	suffer	VERB
fnp-3500	49	7	from	from	ADP
fnp-3500	49	8	brain	brain	NOUN
fnp-3500	49	9	metastasis	metastasis	NOUN
fnp-3500	49	10	,	,	PUNCT
fnp-3500	49	11	which	which	PRON
fnp-3500	49	12	likely	likely	ADV
fnp-3500	49	13	proceed	proceed	VERB
fnp-3500	49	14	continuously	continuously	ADV
fnp-3500	49	15	during	during	ADP
fnp-3500	49	16	the	the	DET
fnp-3500	49	17	course	course	NOUN
fnp-3500	49	18	of	of	ADP
fnp-3500	49	19	disease	disease	NOUN
fnp-3500	49	20	.	.	PUNCT
fnp-3500	50	1	genetically	genetically	ADV
fnp-3500	50	2	and	and	CCONJ
fnp-3500	50	3	molecularly	molecularly	ADV
fnp-3500	50	4	distinct	distinct	ADJ
fnp-3500	50	5	subclones	subclone	NOUN
fnp-3500	50	6	lead	lead	VERB
fnp-3500	50	7	to	to	ADP
fnp-3500	50	8	tumor	tumor	NOUN
fnp-3500	50	9	heterogeneity	heterogeneity	NOUN
fnp-3500	50	10	,	,	PUNCT
fnp-3500	50	11	therapy	therapy	NOUN
fnp-3500	50	12	resistance	resistance	NOUN
fnp-3500	50	13	and	and	CCONJ
fnp-3500	50	14	poor	poor	ADJ
fnp-3500	50	15	prognosis	prognosis	NOUN
fnp-3500	50	16	.	.	PUNCT
fnp-3500	51	1	previous	previous	ADJ
fnp-3500	51	2	studies	study	NOUN
fnp-3500	51	3	suggested	suggest	VERB
fnp-3500	51	4	increased	increase	VERB
fnp-3500	51	5	metastatic	metastatic	ADJ
fnp-3500	51	6	spread	spread	NOUN
fnp-3500	51	7	to	to	ADP
fnp-3500	51	8	and	and	CCONJ
fnp-3500	51	9	within	within	ADP
fnp-3500	51	10	the	the	DET
fnp-3500	51	11	brain	brain	NOUN
fnp-3500	51	12	during	during	ADP
fnp-3500	51	13	braf	braf	NOUN
fnp-3500	51	14	inhibitor	inhibitor	NOUN
fnp-3500	51	15	(	(	PUNCT
fnp-3500	51	16	brafi	brafi	PROPN
fnp-3500	51	17	)	)	PUNCT
fnp-3500	51	18	therapy	therapy	NOUN
fnp-3500	51	19	,	,	PUNCT
fnp-3500	51	20	which	which	PRON
fnp-3500	51	21	is	be	AUX
fnp-3500	51	22	caused	cause	VERB
fnp-3500	51	23	by	by	ADP
fnp-3500	51	24	upregulation	upregulation	NOUN
fnp-3500	51	25	of	of	ADP
fnp-3500	51	26	a	a	DET
fnp-3500	51	27	subset	subset	NOUN
fnp-3500	51	28	of	of	ADP
fnp-3500	51	29	molecular	molecular	ADJ
fnp-3500	51	30	drivers	driver	NOUN
fnp-3500	51	31	that	that	PRON
fnp-3500	51	32	control	control	VERB
fnp-3500	51	33	migratory	migratory	NOUN
fnp-3500	51	34	and	and	CCONJ
fnp-3500	51	35	invasion	invasion	NOUN
fnp-3500	51	36	such	such	ADJ
fnp-3500	51	37	as	as	ADP
fnp-3500	51	38	the	the	DET
fnp-3500	51	39	nerve	nerve	NOUN
fnp-3500	51	40	growth	growth	NOUN
fnp-3500	51	41	factor	factor	NOUN
fnp-3500	51	42	receptor	receptor	NOUN
fnp-3500	51	43	cd271	cd271	NOUN
fnp-3500	51	44	/	/	SYM
fnp-3500	51	45	ngfr	ngfr	NOUN
fnp-3500	51	46	.	.	PUNCT
fnp-3500	52	1	objectives	objective	NOUN
fnp-3500	52	2	:	:	PUNCT
fnp-3500	52	3	to	to	PART
fnp-3500	52	4	investigate	investigate	VERB
fnp-3500	52	5	the	the	DET
fnp-3500	52	6	molecular	molecular	ADJ
fnp-3500	52	7	features	feature	NOUN
fnp-3500	52	8	of	of	ADP
fnp-3500	52	9	migration	migration	NOUN
fnp-3500	52	10	and	and	CCONJ
fnp-3500	52	11	invasion	invasion	NOUN
fnp-3500	52	12	of	of	ADP
fnp-3500	52	13	patient	patient	ADJ
fnp-3500	52	14	derived	derive	VERB
fnp-3500	52	15	cell	cell	NOUN
fnp-3500	52	16	lines	line	NOUN
fnp-3500	52	17	from	from	ADP
fnp-3500	52	18	mm	mm	NUM
fnp-3500	52	19	brain	brain	NOUN
fnp-3500	52	20	metastases	metastasis	NOUN
fnp-3500	52	21	(	(	PUNCT
fnp-3500	52	22	bm	bm	PROPN
fnp-3500	52	23	)	)	PUNCT
fnp-3500	52	24	that	that	PRON
fnp-3500	52	25	were	be	AUX
fnp-3500	52	26	therapy	therapy	NOUN
fnp-3500	52	27	-	-	PUNCT
fnp-3500	52	28	responsive	responsive	ADJ
fnp-3500	52	29	or	or	CCONJ
fnp-3500	52	30	therapy	therapy	NOUN
fnp-3500	52	31	-	-	PUNCT
fnp-3500	52	32	resistant	resistant	ADJ
fnp-3500	52	33	to	to	ADP
fnp-3500	52	34	brafi	brafi	PROPN
fnp-3500	52	35	,	,	PUNCT
fnp-3500	52	36	radiotherapy	radiotherapy	NOUN
fnp-3500	52	37	and	and	CCONJ
fnp-3500	52	38	immune	immune	ADJ
fnp-3500	52	39	checkpoint	checkpoint	NOUN
fnp-3500	52	40	inhibitors	inhibitor	NOUN
fnp-3500	52	41	.	.	PUNCT
fnp-3500	53	1	patients	patient	NOUN
fnp-3500	53	2	&	&	CCONJ
fnp-3500	53	3	methods	method	NOUN
fnp-3500	53	4	:	:	PUNCT
fnp-3500	53	5	we	we	PRON
fnp-3500	53	6	isolated	isolate	VERB
fnp-3500	53	7	and	and	CCONJ
fnp-3500	53	8	cultured	cultured	ADJ
fnp-3500	53	9	patient	patient	ADJ
fnp-3500	53	10	derived	derive	VERB
fnp-3500	53	11	cell	cell	NOUN
fnp-3500	53	12	lines	line	NOUN
fnp-3500	53	13	from	from	ADP
fnp-3500	53	14	mm	mm	PROPN
fnp-3500	53	15	bm	bm	PROPN
fnp-3500	53	16	(	(	PUNCT
fnp-3500	53	17	n	n	NOUN
fnp-3500	53	18	=	=	NOUN
fnp-3500	53	19	9	9	NUM
fnp-3500	53	20	)	)	PUNCT
fnp-3500	53	21	and	and	CCONJ
fnp-3500	53	22	dna	dna	NOUN
fnp-3500	53	23	-	-	PUNCT
fnp-3500	53	24	sequencing	sequence	VERB
fnp-3500	53	25	(	(	PUNCT
fnp-3500	53	26	n	n	NOUN
fnp-3500	53	27	=	=	SYM
fnp-3500	53	28	5	5	NUM
fnp-3500	53	29	)	)	PUNCT
fnp-3500	53	30	and	and	CCONJ
fnp-3500	53	31	transcriptome	transcriptome	ADJ
fnp-3500	53	32	analyses	analysis	NOUN
fnp-3500	53	33	(	(	PUNCT
fnp-3500	53	34	n	n	NOUN
fnp-3500	53	35	=	=	SYM
fnp-3500	53	36	2	2	NUM
fnp-3500	53	37	)	)	PUNCT
fnp-3500	53	38	of	of	ADP
fnp-3500	53	39	cell	cell	NOUN
fnp-3500	53	40	lines	line	NOUN
fnp-3500	53	41	and	and	CCONJ
fnp-3500	53	42	concordant	concordant	ADJ
fnp-3500	53	43	tumor	tumor	NOUN
fnp-3500	53	44	(	(	PUNCT
fnp-3500	53	45	n	n	NOUN
fnp-3500	53	46	=	=	SYM
fnp-3500	53	47	2	2	NUM
fnp-3500	53	48	)	)	PUNCT
fnp-3500	53	49	.	.	PUNCT
fnp-3500	54	1	the	the	DET
fnp-3500	54	2	incucyte	incucyte	PROPN
fnp-3500	54	3	®	®	NOUN
fnp-3500	54	4	live	live	ADJ
fnp-3500	54	5	-	-	PUNCT
fnp-3500	54	6	cell	cell	NOUN
fnp-3500	54	7	analysis	analysis	NOUN
fnp-3500	54	8	was	be	AUX
fnp-3500	54	9	used	use	VERB
fnp-3500	54	10	to	to	PART
fnp-3500	54	11	perform	perform	VERB
fnp-3500	54	12	high	high	ADJ
fnp-3500	54	13	throughput	throughput	NOUN
fnp-3500	54	14	scratch	scratch	NOUN
fnp-3500	54	15	wound	wound	NOUN
fnp-3500	54	16	assays	assay	NOUN
fnp-3500	54	17	with	with	ADP
fnp-3500	54	18	patient	patient	ADJ
fnp-3500	54	19	derived	derive	VERB
fnp-3500	54	20	cell	cell	NOUN
fnp-3500	54	21	lines	line	NOUN
fnp-3500	54	22	,	,	PUNCT
fnp-3500	54	23	which	which	PRON
fnp-3500	54	24	were	be	AUX
fnp-3500	54	25	genetically	genetically	ADV
fnp-3500	54	26	modified	modify	VERB
fnp-3500	54	27	to	to	ADP
fnp-3500	54	28	overexpress	overexpress	NOUN
fnp-3500	54	29	or	or	CCONJ
fnp-3500	54	30	downregulate	downregulate	VERB
fnp-3500	54	31	the	the	DET
fnp-3500	54	32	expression	expression	NOUN
fnp-3500	54	33	of	of	ADP
fnp-3500	54	34	ngfr	ngfr	NOUN
fnp-3500	54	35	.	.	PUNCT
fnp-3500	55	1	results	result	NOUN
fnp-3500	55	2	:	:	PUNCT
fnp-3500	55	3	transcriptome	transcriptome	ADJ
fnp-3500	55	4	profiling	profiling	NOUN
fnp-3500	55	5	of	of	ADP
fnp-3500	55	6	brafi	brafi	PROPN
fnp-3500	55	7	resistant	resistant	ADJ
fnp-3500	55	8	mm	mm	PROPN
fnp-3500	55	9	bm	bm	PROPN
fnp-3500	55	10	revealed	reveal	VERB
fnp-3500	55	11	that	that	SCONJ
fnp-3500	55	12	the	the	DET
fnp-3500	55	13	invasive	invasive	ADJ
fnp-3500	55	14	potential	potential	NOUN
fnp-3500	55	15	increased	increase	VERB
fnp-3500	55	16	during	during	ADP
fnp-3500	55	17	disease	disease	NOUN
fnp-3500	55	18	progression	progression	NOUN
fnp-3500	55	19	,	,	PUNCT
fnp-3500	55	20	which	which	PRON
fnp-3500	55	21	was	be	AUX
fnp-3500	55	22	accompanied	accompany	VERB
fnp-3500	55	23	by	by	ADP
fnp-3500	55	24	upregulation	upregulation	NOUN
fnp-3500	55	25	of	of	ADP
fnp-3500	55	26	ngfr	ngfr	NOUN
fnp-3500	55	27	expression	expression	NOUN
fnp-3500	55	28	.	.	PUNCT
fnp-3500	56	1	this	this	DET
fnp-3500	56	2	phenotype	phenotype	NOUN
fnp-3500	56	3	was	be	AUX
fnp-3500	56	4	preserved	preserve	VERB
fnp-3500	56	5	in	in	ADP
fnp-3500	56	6	patient	patient	ADJ
fnp-3500	56	7	derived	derive	VERB
fnp-3500	56	8	cells	cell	NOUN
fnp-3500	56	9	lines	line	NOUN
fnp-3500	56	10	,	,	PUNCT
fnp-3500	56	11	which	which	PRON
fnp-3500	56	12	demonstrated	demonstrate	VERB
fnp-3500	56	13	significantly	significantly	ADV
fnp-3500	56	14	higher	high	ADJ
fnp-3500	56	15	potential	potential	NOUN
fnp-3500	56	16	of	of	ADP
fnp-3500	56	17	two	two	NUM
fnp-3500	56	18	-	-	PUNCT
fnp-3500	56	19	dimensional	dimensional	ADJ
fnp-3500	56	20	in	in	ADP
fnp-3500	56	21	vitro	vitro	X
fnp-3500	56	22	migration	migration	NOUN
fnp-3500	56	23	(	(	PUNCT
fnp-3500	56	24	90	90	NUM
fnp-3500	56	25	%	%	NOUN
fnp-3500	56	26	vs.	vs.	ADP
fnp-3500	56	27	76	76	NUM
fnp-3500	56	28	%	%	NOUN
fnp-3500	56	29	after	after	ADP
fnp-3500	56	30	100	100	NUM
fnp-3500	56	31	hours	hour	NOUN
fnp-3500	56	32	)	)	PUNCT
fnp-3500	56	33	.	.	PUNCT
fnp-3500	57	1	furthermore	furthermore	ADV
fnp-3500	57	2	,	,	PUNCT
fnp-3500	57	3	cd271	cd271	PROPN
fnp-3500	57	4	knockdown	knockdown	NOUN
fnp-3500	57	5	was	be	AUX
fnp-3500	57	6	associated	associate	VERB
fnp-3500	57	7	with	with	ADP
fnp-3500	57	8	loss	loss	NOUN
fnp-3500	57	9	-	-	PUNCT
fnp-3500	57	10	of	of	ADP
fnp-3500	57	11	-	-	PUNCT
fnp-3500	57	12	expression	expression	NOUN
fnp-3500	57	13	of	of	ADP
fnp-3500	57	14	several	several	ADJ
fnp-3500	57	15	genes	gene	NOUN
fnp-3500	57	16	involved	involve	VERB
fnp-3500	57	17	in	in	ADP
fnp-3500	57	18	migration	migration	NOUN
fnp-3500	57	19	and	and	CCONJ
fnp-3500	57	20	invasion	invasion	NOUN
fnp-3500	57	21	such	such	ADJ
fnp-3500	57	22	as	as	ADP
fnp-3500	57	23	erbb3	erbb3	PROPN
fnp-3500	57	24	,	,	PUNCT
fnp-3500	57	25	tcf19	tcf19	NOUN
fnp-3500	57	26	and	and	CCONJ
fnp-3500	57	27	baalc	baalc	NOUN
fnp-3500	57	28	.	.	PUNCT
fnp-3500	58	1	conclusion	conclusion	NOUN
fnp-3500	58	2	:	:	PUNCT
fnp-3500	58	3	brain	brain	NOUN
fnp-3500	58	4	metastases	metastasis	NOUN
fnp-3500	58	5	are	be	AUX
fnp-3500	58	6	the	the	DET
fnp-3500	58	7	major	major	ADJ
fnp-3500	58	8	cause	cause	NOUN
fnp-3500	58	9	of	of	ADP
fnp-3500	58	10	death	death	NOUN
fnp-3500	58	11	in	in	ADP
fnp-3500	58	12	metastasized	metastasized	ADJ
fnp-3500	58	13	mm	mm	NOUN
fnp-3500	58	14	.	.	PUNCT
fnp-3500	59	1	our	our	PRON
fnp-3500	59	2	study	study	NOUN
fnp-3500	59	3	provides	provide	VERB
fnp-3500	59	4	a	a	DET
fnp-3500	59	5	longitudinal	longitudinal	ADJ
fnp-3500	59	6	perspective	perspective	NOUN
fnp-3500	59	7	on	on	ADP
fnp-3500	59	8	the	the	DET
fnp-3500	59	9	progression	progression	NOUN
fnp-3500	59	10	of	of	ADP
fnp-3500	59	11	brain	brain	NOUN
fnp-3500	59	12	metastasis	metastasis	NOUN
fnp-3500	59	13	and	and	CCONJ
fnp-3500	59	14	their	their	PRON
fnp-3500	59	15	mechanisms	mechanism	NOUN
fnp-3500	59	16	leading	lead	VERB
fnp-3500	59	17	to	to	ADP
fnp-3500	59	18	therapy	therapy	NOUN
fnp-3500	59	19	resistance	resistance	NOUN
fnp-3500	59	20	.	.	PUNCT
fnp-3500	59	21	  	  	SPACE
fnp-3500	60	1	noa-02	noa-02	PROPN
fnp-3500	60	2	free	free	ADJ
fnp-3500	60	3	neuropathol	neuropathol	NOUN
fnp-3500	60	4	2:22:9	2:22:9	PRON
fnp-3500	60	5	molecular	molecular	ADJ
fnp-3500	60	6	characterization	characterization	NOUN
fnp-3500	60	7	of	of	ADP
fnp-3500	60	8	sporadic	sporadic	ADJ
fnp-3500	60	9	endolymphatic	endolymphatic	ADJ
fnp-3500	60	10	sac	sac	NOUN
fnp-3500	60	11	tumours	tumour	NOUN
fnp-3500	60	12	and	and	CCONJ
fnp-3500	60	13	comparison	comparison	NOUN
fnp-3500	60	14	to	to	ADP
fnp-3500	60	15	von	von	PROPN
fnp-3500	60	16	hippel	hippel	PROPN
fnp-3500	60	17	-	-	PUNCT
fnp-3500	60	18	lindau	lindau	NOUN
fnp-3500	60	19	disease	disease	NOUN
fnp-3500	60	20	-	-	PUNCT
fnp-3500	60	21	related	relate	VERB
fnp-3500	60	22	tumours	tumour	NOUN
fnp-3500	60	23	l.	l.	PROPN
fnp-3500	60	24	schweizer1	schweizer1	PROPN
fnp-3500	60	25	,	,	PUNCT
fnp-3500	60	26	f.	f.	PROPN
fnp-3500	60	27	thierfelder1	thierfelder1	PROPN
fnp-3500	60	28	,	,	PUNCT
fnp-3500	60	29	c.	c.	PROPN
fnp-3500	60	30	thomas2	thomas2	PROPN
fnp-3500	60	31	,	,	PUNCT
fnp-3500	60	32	p.	p.	PROPN
fnp-3500	60	33	soschinski2	soschinski2	PROPN
fnp-3500	60	34	,	,	PUNCT
fnp-3500	60	35	h.	h.	PROPN
fnp-3500	60	36	y.	y.	PROPN
fnp-3500	60	37	kim1	kim1	PROPN
fnp-3500	60	38	,	,	PUNCT
fnp-3500	60	39	r.	r.	PROPN
fnp-3500	60	40	jödicke1	jödicke1	PROPN
fnp-3500	60	41	,	,	PUNCT
fnp-3500	60	42	n.	n.	PROPN
fnp-3500	60	43	woltering2	woltering2	PROPN
fnp-3500	60	44	,	,	PUNCT
fnp-3500	60	45	a.	a.	NOUN
fnp-3500	60	46	förster1	förster1	PROPN
fnp-3500	60	47	,	,	PUNCT
fnp-3500	60	48	d.	d.	PROPN
fnp-3500	60	49	teichmann1	teichmann1	PROPN
fnp-3500	60	50	,	,	PUNCT
fnp-3500	60	51	c.	c.	PROPN
fnp-3500	60	52	siewert1	siewert1	PROPN
fnp-3500	60	53	,	,	PUNCT
fnp-3500	60	54	k.	k.	PROPN
fnp-3500	60	55	klein1	klein1	PROPN
fnp-3500	60	56	,	,	PUNCT
fnp-3500	60	57	s.	s.	PROPN
fnp-3500	60	58	schmid1	schmid1	PROPN
fnp-3500	60	59	,	,	PUNCT
fnp-3500	60	60	m.	m.	NOUN
fnp-3500	60	61	nunninger3	nunninger3	NOUN
fnp-3500	60	62	,	,	PUNCT
fnp-3500	60	63	u.	u.	PROPN
fnp-3500	60	64	w.	w.	PROPN
fnp-3500	60	65	thomale4	thomale4	PROPN
fnp-3500	60	66	,	,	PUNCT
fnp-3500	60	67	j.	j.	PROPN
fnp-3500	60	68	onken5	onken5	PROPN
fnp-3500	60	69	,	,	PUNCT
fnp-3500	60	70	h.	h.	PROPN
fnp-3500	60	71	mühleisen6	mühleisen6	PROPN
fnp-3500	60	72	,	,	PUNCT
fnp-3500	60	73	j.	j.	PROPN
fnp-3500	60	74	schittenhelm7	schittenhelm7	PROPN
fnp-3500	60	75	,	,	PUNCT
fnp-3500	60	76	m.	m.	NOUN
fnp-3500	60	77	tatagiba8	tatagiba8	PROPN
fnp-3500	60	78	,	,	PUNCT
fnp-3500	60	79	a.	a.	PROPN
fnp-3500	60	80	von	von	PROPN
fnp-3500	60	81	deimling9	deimling9	PROPN
fnp-3500	60	82	,	,	PUNCT
fnp-3500	60	83	d.	d.	PROPN
fnp-3500	60	84	e.	e.	PROPN
fnp-3500	60	85	reuss9	reuss9	PROPN
fnp-3500	60	86	,	,	PUNCT
fnp-3500	60	87	d.	d.	PROPN
fnp-3500	60	88	a.	a.	PROPN
fnp-3500	60	89	solomon10	solomon10	PROPN
fnp-3500	60	90	,	,	PUNCT
fnp-3500	60	91	f.	f.	PROPN
fnp-3500	60	92	l.	l.	PROPN
fnp-3500	60	93	heppner1	heppner1	PROPN
fnp-3500	60	94	,	,	PUNCT
fnp-3500	60	95	a.	a.	PROPN
fnp-3500	60	96	koch1	koch1	PROPN
fnp-3500	60	97	,	,	PUNCT
fnp-3500	60	98	c.	c.	PROPN
fnp-3500	60	99	hartmann11	hartmann11	PROPN
fnp-3500	60	100	,	,	PUNCT
fnp-3500	60	101	o.	o.	PROPN
fnp-3500	60	102	staszewski12	staszewski12	PROPN
fnp-3500	60	103	,	,	PUNCT
fnp-3500	60	104	d.	d.	PROPN
fnp-3500	60	105	capper1	capper1	PROPN
fnp-3500	60	106	1	1	NUM
fnp-3500	60	107	charité	charité	ADJ
fnp-3500	60	108	–	–	PUNCT
fnp-3500	60	109	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	60	110	berlin	berlin	PROPN
fnp-3500	60	111	,	,	PUNCT
fnp-3500	60	112	department	department	NOUN
fnp-3500	60	113	of	of	ADP
fnp-3500	60	114	neuropathology	neuropathology	NOUN
fnp-3500	60	115	,	,	PUNCT
fnp-3500	60	116	berlin	berlin	PROPN
fnp-3500	60	117	,	,	PUNCT
fnp-3500	60	118	germany	germany	PROPN
fnp-3500	60	119	2	2	NUM
fnp-3500	60	120	university	university	NOUN
fnp-3500	60	121	hospital	hospital	NOUN
fnp-3500	60	122	münster	münster	NOUN
fnp-3500	60	123	,	,	PUNCT
fnp-3500	60	124	department	department	NOUN
fnp-3500	60	125	of	of	ADP
fnp-3500	60	126	neuropathology	neuropathology	NOUN
fnp-3500	60	127	,	,	PUNCT
fnp-3500	60	128	münster	münster	PROPN
fnp-3500	60	129	,	,	PUNCT
fnp-3500	60	130	germany	germany	PROPN
fnp-3500	60	131	3	3	NUM
fnp-3500	60	132	charité	charité	PROPN
fnp-3500	60	133	–	–	PUNCT
fnp-3500	60	134	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	60	135	berlin	berlin	PROPN
fnp-3500	60	136	,	,	PUNCT
fnp-3500	60	137	department	department	NOUN
fnp-3500	60	138	of	of	ADP
fnp-3500	60	139	radiology	radiology	NOUN
fnp-3500	60	140	,	,	PUNCT
fnp-3500	60	141	berlin	berlin	PROPN
fnp-3500	60	142	,	,	PUNCT
fnp-3500	60	143	germany	germany	PROPN
fnp-3500	60	144	4	4	NUM
fnp-3500	60	145	charité	charité	PROPN
fnp-3500	60	146	–	–	PUNCT
fnp-3500	60	147	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	60	148	berlin	berlin	PROPN
fnp-3500	60	149	,	,	PUNCT
fnp-3500	60	150	department	department	NOUN
fnp-3500	60	151	of	of	ADP
fnp-3500	60	152	neurosurgery	neurosurgery	NOUN
fnp-3500	60	153	,	,	PUNCT
fnp-3500	60	154	division	division	NOUN
fnp-3500	60	155	pediatric	pediatric	ADJ
fnp-3500	60	156	neurosurgery	neurosurgery	NOUN
fnp-3500	60	157	,	,	PUNCT
fnp-3500	60	158	berlin	berlin	PROPN
fnp-3500	60	159	,	,	PUNCT
fnp-3500	60	160	germany	germany	PROPN
fnp-3500	60	161	5	5	NUM
fnp-3500	60	162	charité	charité	PROPN
fnp-3500	60	163	–	–	PUNCT
fnp-3500	60	164	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	60	165	berlin	berlin	PROPN
fnp-3500	60	166	,	,	PUNCT
fnp-3500	60	167	department	department	NOUN
fnp-3500	60	168	of	of	ADP
fnp-3500	60	169	neurosurgery	neurosurgery	NOUN
fnp-3500	60	170	,	,	PUNCT
fnp-3500	60	171	berlin	berlin	PROPN
fnp-3500	60	172	,	,	PUNCT
fnp-3500	60	173	germany	germany	PROPN
fnp-3500	60	174	6	6	NUM
fnp-3500	60	175	synlab	synlab	NOUN
fnp-3500	60	176	labor	labor	PROPN
fnp-3500	60	177	für	für	PROPN
fnp-3500	60	178	pathologie	pathologie	PROPN
fnp-3500	60	179	mutlangen	mutlangen	PROPN
fnp-3500	60	180	,	,	PUNCT
fnp-3500	60	181	mutlangen	mutlangen	PROPN
fnp-3500	60	182	,	,	PUNCT
fnp-3500	60	183	germany	germany	PROPN
fnp-3500	60	184	7	7	NUM
fnp-3500	60	185	institute	institute	PROPN
fnp-3500	60	186	of	of	ADP
fnp-3500	60	187	pathology	pathology	PROPN
fnp-3500	60	188	and	and	CCONJ
fnp-3500	60	189	neuropathology	neuropathology	NOUN
fnp-3500	60	190	,	,	PUNCT
fnp-3500	60	191	university	university	NOUN
fnp-3500	60	192	of	of	ADP
fnp-3500	60	193	tübingen	tübingen	PROPN
fnp-3500	60	194	,	,	PUNCT
fnp-3500	60	195	department	department	NOUN
fnp-3500	60	196	of	of	ADP
fnp-3500	60	197	neuropathology	neuropathology	NOUN
fnp-3500	60	198	,	,	PUNCT
fnp-3500	60	199	tübingen	tübingen	PROPN
fnp-3500	60	200	,	,	PUNCT
fnp-3500	60	201	germany	germany	PROPN
fnp-3500	60	202	8	8	NUM
fnp-3500	60	203	university	university	PROPN
fnp-3500	60	204	hospital	hospital	NOUN
fnp-3500	60	205	tübingen	tübingen	PROPN
fnp-3500	60	206	,	,	PUNCT
fnp-3500	60	207	department	department	NOUN
fnp-3500	60	208	of	of	ADP
fnp-3500	60	209	neurosurgery	neurosurgery	NOUN
fnp-3500	60	210	,	,	PUNCT
fnp-3500	60	211	tübingen	tübingen	PROPN
fnp-3500	60	212	,	,	PUNCT
fnp-3500	60	213	germany	germany	PROPN
fnp-3500	60	214	9	9	NUM
fnp-3500	60	215	heidelberg	heidelberg	PROPN
fnp-3500	60	216	university	university	PROPN
fnp-3500	60	217	hospital	hospital	NOUN
fnp-3500	60	218	,	,	PUNCT
fnp-3500	60	219	department	department	NOUN
fnp-3500	60	220	of	of	ADP
fnp-3500	60	221	neuropathology	neuropathology	NOUN
fnp-3500	60	222	,	,	PUNCT
fnp-3500	60	223	institute	institute	PROPN
fnp-3500	60	224	of	of	ADP
fnp-3500	60	225	pathology	pathology	PROPN
fnp-3500	60	226	,	,	PUNCT
fnp-3500	60	227	heidelberg	heidelberg	PROPN
fnp-3500	60	228	,	,	PUNCT
fnp-3500	60	229	germany	germany	PROPN
fnp-3500	60	230	10	10	NUM
fnp-3500	60	231	university	university	PROPN
fnp-3500	60	232	of	of	ADP
fnp-3500	60	233	california	california	PROPN
fnp-3500	60	234	,	,	PUNCT
fnp-3500	60	235	division	division	NOUN
fnp-3500	60	236	of	of	ADP
fnp-3500	60	237	neuropathology	neuropathology	NOUN
fnp-3500	60	238	,	,	PUNCT
fnp-3500	60	239	department	department	NOUN
fnp-3500	60	240	of	of	ADP
fnp-3500	60	241	pathology	pathology	PROPN
fnp-3500	60	242	,	,	PUNCT
fnp-3500	60	243	san	san	PROPN
fnp-3500	60	244	francisco	francisco	PROPN
fnp-3500	60	245	,	,	PUNCT
fnp-3500	60	246	ca	ca	PROPN
fnp-3500	60	247	,	,	PUNCT
fnp-3500	60	248	united	united	PROPN
fnp-3500	60	249	states	states	PROPN
fnp-3500	60	250	11	11	NUM
fnp-3500	60	251	hannover	hannover	PROPN
fnp-3500	60	252	medical	medical	PROPN
fnp-3500	60	253	school	school	NOUN
fnp-3500	60	254	(	(	PUNCT
fnp-3500	60	255	mhh	mhh	PROPN
fnp-3500	60	256	)	)	PUNCT
fnp-3500	60	257	,	,	PUNCT
fnp-3500	60	258	department	department	NOUN
fnp-3500	60	259	of	of	ADP
fnp-3500	60	260	neuropathology	neuropathology	NOUN
fnp-3500	60	261	,	,	PUNCT
fnp-3500	60	262	hannover	hannover	PROPN
fnp-3500	60	263	,	,	PUNCT
fnp-3500	60	264	germany	germany	PROPN
fnp-3500	60	265	12	12	NUM
fnp-3500	60	266	faculty	faculty	NOUN
fnp-3500	60	267	of	of	ADP
fnp-3500	60	268	medicine	medicine	NOUN
fnp-3500	60	269	,	,	PUNCT
fnp-3500	60	270	university	university	NOUN
fnp-3500	60	271	of	of	ADP
fnp-3500	60	272	freiburg	freiburg	PROPN
fnp-3500	60	273	,	,	PUNCT
fnp-3500	60	274	institute	institute	NOUN
fnp-3500	60	275	of	of	ADP
fnp-3500	60	276	neuropathology	neuropathology	NOUN
fnp-3500	60	277	,	,	PUNCT
fnp-3500	60	278	freiburg	freiburg	PROPN
fnp-3500	60	279	i.	i.	PROPN
fnp-3500	60	280	br	br	PROPN
fnp-3500	60	281	.	.	PROPN
fnp-3500	60	282	,	,	PUNCT
fnp-3500	60	283	germany	germany	PROPN
fnp-3500	60	284	introduction	introduction	NOUN
fnp-3500	60	285	.	.	PUNCT
fnp-3500	61	1	endolymphatic	endolymphatic	ADJ
fnp-3500	61	2	sac	sac	NOUN
fnp-3500	61	3	tumours	tumour	NOUN
fnp-3500	61	4	(	(	PUNCT
fnp-3500	61	5	elsts	elst	NOUN
fnp-3500	61	6	)	)	PUNCT
fnp-3500	61	7	are	be	AUX
fnp-3500	61	8	low	low	ADJ
fnp-3500	61	9	-	-	PUNCT
fnp-3500	61	10	grade	grade	NOUN
fnp-3500	61	11	tumours	tumour	NOUN
fnp-3500	61	12	arising	arise	VERB
fnp-3500	61	13	from	from	ADP
fnp-3500	61	14	the	the	DET
fnp-3500	61	15	endolymphatic	endolymphatic	ADJ
fnp-3500	61	16	sac	sac	NOUN
fnp-3500	61	17	in	in	ADP
fnp-3500	61	18	the	the	DET
fnp-3500	61	19	temporal	temporal	ADJ
fnp-3500	61	20	bone	bone	NOUN
fnp-3500	61	21	.	.	PUNCT
fnp-3500	62	1	elsts	elst	NOUN
fnp-3500	62	2	can	can	AUX
fnp-3500	62	3	be	be	AUX
fnp-3500	62	4	locally	locally	ADV
fnp-3500	62	5	aggressive	aggressive	ADJ
fnp-3500	62	6	and	and	CCONJ
fnp-3500	62	7	may	may	AUX
fnp-3500	62	8	even	even	ADV
fnp-3500	62	9	expand	expand	VERB
fnp-3500	62	10	into	into	ADP
fnp-3500	62	11	the	the	DET
fnp-3500	62	12	posterior	posterior	ADJ
fnp-3500	62	13	fossa	fossa	NOUN
fnp-3500	62	14	representing	represent	VERB
fnp-3500	62	15	a	a	DET
fnp-3500	62	16	rare	rare	ADJ
fnp-3500	62	17	differential	differential	ADJ
fnp-3500	62	18	diagnosis	diagnosis	NOUN
fnp-3500	62	19	for	for	ADP
fnp-3500	62	20	tumours	tumour	NOUN
fnp-3500	62	21	of	of	ADP
fnp-3500	62	22	the	the	DET
fnp-3500	62	23	cerebellopontine	cerebellopontine	NOUN
fnp-3500	62	24	angle	angle	NOUN
fnp-3500	62	25	.	.	PUNCT
fnp-3500	63	1	although	although	SCONJ
fnp-3500	63	2	inactivation	inactivation	NOUN
fnp-3500	63	3	of	of	ADP
fnp-3500	63	4	the	the	DET
fnp-3500	63	5	von	von	PROPN
fnp-3500	63	6	hippel	hippel	PROPN
fnp-3500	63	7	-	-	PUNCT
fnp-3500	63	8	lindau	lindau	NOUN
fnp-3500	63	9	gene	gene	NOUN
fnp-3500	63	10	(	(	PUNCT
fnp-3500	63	11	vhl	vhl	NOUN
fnp-3500	63	12	)	)	PUNCT
fnp-3500	63	13	on	on	ADP
fnp-3500	63	14	chromosome	chromosome	NOUN
fnp-3500	63	15	3p25	3p25	NUM
fnp-3500	63	16	is	be	AUX
fnp-3500	63	17	considered	consider	VERB
fnp-3500	63	18	to	to	PART
fnp-3500	63	19	be	be	AUX
fnp-3500	63	20	the	the	DET
fnp-3500	63	21	major	major	ADJ
fnp-3500	63	22	cause	cause	NOUN
fnp-3500	63	23	of	of	ADP
fnp-3500	63	24	hereditary	hereditary	ADJ
fnp-3500	63	25	endolymphatic	endolymphatic	ADJ
fnp-3500	63	26	sac	sac	NOUN
fnp-3500	63	27	tumours	tumour	NOUN
fnp-3500	63	28	(	(	PUNCT
fnp-3500	63	29	elsts	elsts	PROPN
fnp-3500	63	30	)	)	PUNCT
fnp-3500	63	31	,	,	PUNCT
fnp-3500	63	32	the	the	DET
fnp-3500	63	33	genetic	genetic	ADJ
fnp-3500	63	34	background	background	NOUN
fnp-3500	63	35	of	of	ADP
fnp-3500	63	36	sporadic	sporadic	ADJ
fnp-3500	63	37	elst	elst	NOUN
fnp-3500	63	38	is	be	AUX
fnp-3500	63	39	largely	largely	ADV
fnp-3500	63	40	unknown	unknown	ADJ
fnp-3500	63	41	.	.	PUNCT
fnp-3500	64	1	objectives	objective	NOUN
fnp-3500	64	2	.	.	PUNCT
fnp-3500	65	1	the	the	DET
fnp-3500	65	2	aim	aim	NOUN
fnp-3500	65	3	of	of	ADP
fnp-3500	65	4	this	this	DET
fnp-3500	65	5	study	study	NOUN
fnp-3500	65	6	was	be	AUX
fnp-3500	65	7	to	to	PART
fnp-3500	65	8	determine	determine	VERB
fnp-3500	65	9	the	the	DET
fnp-3500	65	10	prevalence	prevalence	NOUN
fnp-3500	65	11	of	of	ADP
fnp-3500	65	12	vhl	vhl	PROPN
fnp-3500	65	13	alterations	alteration	NOUN
fnp-3500	65	14	in	in	ADP
fnp-3500	65	15	sporadic	sporadic	ADJ
fnp-3500	65	16	elsts	elst	NOUN
fnp-3500	65	17	and	and	CCONJ
fnp-3500	65	18	compare	compare	VERB
fnp-3500	65	19	their	their	PRON
fnp-3500	65	20	characteristics	characteristic	NOUN
fnp-3500	65	21	to	to	ADP
fnp-3500	65	22	vhl	vhl	NOUN
fnp-3500	65	23	-	-	PUNCT
fnp-3500	65	24	disease	disease	NOUN
fnp-3500	65	25	-	-	PUNCT
fnp-3500	65	26	related	relate	VERB
fnp-3500	65	27	tumours	tumour	NOUN
fnp-3500	65	28	.	.	PUNCT
fnp-3500	66	1	materials	material	NOUN
fnp-3500	66	2	and	and	CCONJ
fnp-3500	66	3	methods	method	NOUN
fnp-3500	66	4	.	.	PUNCT
fnp-3500	67	1	we	we	PRON
fnp-3500	67	2	analyzed	analyze	VERB
fnp-3500	67	3	11	11	NUM
fnp-3500	67	4	sporadic	sporadic	ADJ
fnp-3500	67	5	and	and	CCONJ
fnp-3500	67	6	11	11	NUM
fnp-3500	67	7	vhl	vhl	NOUN
fnp-3500	67	8	-	-	PUNCT
fnp-3500	67	9	disease	disease	NOUN
fnp-3500	67	10	-	-	PUNCT
fnp-3500	67	11	related	relate	VERB
fnp-3500	67	12	elsts	elst	NOUN
fnp-3500	67	13	by	by	ADP
fnp-3500	67	14	targeted	target	VERB
fnp-3500	67	15	sequencing	sequencing	NOUN
fnp-3500	67	16	and	and	CCONJ
fnp-3500	67	17	dna	dna	PROPN
fnp-3500	67	18	methylation	methylation	NOUN
fnp-3500	67	19	analysis	analysis	NOUN
fnp-3500	67	20	.	.	PUNCT
fnp-3500	68	1	results	result	NOUN
fnp-3500	68	2	.	.	PUNCT
fnp-3500	69	1	vhl	vhl	NOUN
fnp-3500	69	2	mutations	mutation	NOUN
fnp-3500	69	3	and	and	CCONJ
fnp-3500	69	4	small	small	ADJ
fnp-3500	69	5	deletions	deletion	NOUN
fnp-3500	69	6	detected	detect	VERB
fnp-3500	69	7	by	by	ADP
fnp-3500	69	8	targeted	target	VERB
fnp-3500	69	9	deep	deep	ADJ
fnp-3500	69	10	sequencing	sequencing	NOUN
fnp-3500	69	11	were	be	AUX
fnp-3500	69	12	identified	identify	VERB
fnp-3500	69	13	in	in	ADP
fnp-3500	69	14	9/11	9/11	NUM
fnp-3500	69	15	sporadic	sporadic	ADJ
fnp-3500	69	16	elsts	elst	NOUN
fnp-3500	69	17	(	(	PUNCT
fnp-3500	69	18	82	82	NUM
fnp-3500	69	19	%	%	NOUN
fnp-3500	69	20	)	)	PUNCT
fnp-3500	69	21	.	.	PUNCT
fnp-3500	70	1	no	no	DET
fnp-3500	70	2	other	other	ADJ
fnp-3500	70	3	cancer	cancer	NOUN
fnp-3500	70	4	-	-	PUNCT
fnp-3500	70	5	related	relate	VERB
fnp-3500	70	6	genetic	genetic	ADJ
fnp-3500	70	7	pathway	pathway	NOUN
fnp-3500	70	8	was	be	AUX
fnp-3500	70	9	altered	alter	VERB
fnp-3500	70	10	except	except	SCONJ
fnp-3500	70	11	for	for	ADP
fnp-3500	70	12	tert	tert	NOUN
fnp-3500	70	13	promoter	promoter	NOUN
fnp-3500	70	14	mutations	mutation	NOUN
fnp-3500	70	15	in	in	ADP
fnp-3500	70	16	two	two	NUM
fnp-3500	70	17	sporadic	sporadic	ADJ
fnp-3500	70	18	and	and	CCONJ
fnp-3500	70	19	one	one	NUM
fnp-3500	70	20	vhl	vhl	ADJ
fnp-3500	70	21	-	-	PUNCT
fnp-3500	70	22	disease	disease	NOUN
fnp-3500	70	23	-	-	PUNCT
fnp-3500	70	24	related	relate	VERB
fnp-3500	70	25	elsts	elst	NOUN
fnp-3500	70	26	(	(	PUNCT
fnp-3500	70	27	15	15	NUM
fnp-3500	70	28	%	%	NOUN
fnp-3500	70	29	)	)	PUNCT
fnp-3500	70	30	.	.	PUNCT
fnp-3500	71	1	loss	loss	NOUN
fnp-3500	71	2	of	of	ADP
fnp-3500	71	3	heterozygosity	heterozygosity	NOUN
fnp-3500	71	4	of	of	ADP
fnp-3500	71	5	chromosome	chromosome	NOUN
fnp-3500	71	6	3	3	NUM
fnp-3500	71	7	was	be	AUX
fnp-3500	71	8	found	find	VERB
fnp-3500	71	9	in	in	ADP
fnp-3500	71	10	6/10	6/10	NUM
fnp-3500	71	11	(	(	PUNCT
fnp-3500	71	12	60	60	NUM
fnp-3500	71	13	%	%	NOUN
fnp-3500	71	14	)	)	PUNCT
fnp-3500	71	15	vhl	vhl	NOUN
fnp-3500	71	16	-	-	PUNCT
fnp-3500	71	17	disease	disease	NOUN
fnp-3500	71	18	-	-	PUNCT
fnp-3500	71	19	related	relate	VERB
fnp-3500	71	20	and	and	CCONJ
fnp-3500	71	21	10/11	10/11	NUM
fnp-3500	71	22	(	(	PUNCT
fnp-3500	71	23	91	91	NUM
fnp-3500	71	24	%	%	NOUN
fnp-3500	71	25	)	)	PUNCT
fnp-3500	72	1	sporadic	sporadic	ADJ
fnp-3500	72	2	elsts	elst	NOUN
fnp-3500	72	3	resulting	result	VERB
fnp-3500	72	4	in	in	ADP
fnp-3500	72	5	biallelic	biallelic	ADJ
fnp-3500	72	6	vhl	vhl	NOUN
fnp-3500	72	7	inactivation	inactivation	NOUN
fnp-3500	72	8	in	in	ADP
fnp-3500	72	9	8/10	8/10	NUM
fnp-3500	72	10	(	(	PUNCT
fnp-3500	72	11	73	73	NUM
fnp-3500	72	12	%	%	NOUN
fnp-3500	72	13	)	)	PUNCT
fnp-3500	72	14	sporadic	sporadic	ADJ
fnp-3500	72	15	elsts	elst	NOUN
fnp-3500	72	16	.	.	PUNCT
fnp-3500	73	1	dna	dna	PROPN
fnp-3500	73	2	methylation	methylation	NOUN
fnp-3500	73	3	profiling	profiling	NOUN
fnp-3500	73	4	did	do	AUX
fnp-3500	73	5	not	not	PART
fnp-3500	73	6	reveal	reveal	VERB
fnp-3500	73	7	differences	difference	NOUN
fnp-3500	73	8	between	between	ADP
fnp-3500	73	9	sporadic	sporadic	ADJ
fnp-3500	73	10	and	and	CCONJ
fnp-3500	73	11	vhl	vhl	NOUN
fnp-3500	73	12	-	-	PUNCT
fnp-3500	73	13	disease	disease	NOUN
fnp-3500	73	14	-	-	PUNCT
fnp-3500	73	15	related	relate	VERB
fnp-3500	73	16	elsts	elst	NOUN
fnp-3500	73	17	,	,	PUNCT
fnp-3500	73	18	but	but	CCONJ
fnp-3500	73	19	reliably	reliably	ADV
fnp-3500	73	20	distinguished	distinguish	VERB
fnp-3500	73	21	elst	elst	NOUN
fnp-3500	73	22	from	from	ADP
fnp-3500	73	23	morphological	morphological	ADJ
fnp-3500	73	24	mimics	mimic	NOUN
fnp-3500	73	25	of	of	ADP
fnp-3500	73	26	the	the	DET
fnp-3500	73	27	cerebellopontine	cerebellopontine	NOUN
fnp-3500	73	28	angle	angle	NOUN
fnp-3500	73	29	.	.	PUNCT
fnp-3500	74	1	vhl	vhl	PROPN
fnp-3500	74	2	patients	patient	NOUN
fnp-3500	74	3	were	be	AUX
fnp-3500	74	4	significantly	significantly	ADV
fnp-3500	74	5	younger	young	ADJ
fnp-3500	74	6	at	at	ADP
fnp-3500	74	7	disease	disease	NOUN
fnp-3500	74	8	onset	onset	NOUN
fnp-3500	74	9	compared	compare	VERB
fnp-3500	74	10	to	to	ADP
fnp-3500	74	11	sporadic	sporadic	ADJ
fnp-3500	74	12	elsts	elst	NOUN
fnp-3500	74	13	(	(	PUNCT
fnp-3500	74	14	29	29	NUM
fnp-3500	74	15	vs.	vs.	ADP
fnp-3500	74	16	52	52	NUM
fnp-3500	74	17	years	year	NOUN
fnp-3500	74	18	,	,	PUNCT
fnp-3500	74	19	p	p	X
fnp-3500	74	20	<	<	X
fnp-3500	74	21	0.0001	0.0001	NUM
fnp-3500	74	22	,	,	PUNCT
fnp-3500	74	23	fisher	fisher	PROPN
fnp-3500	74	24	's	's	PART
fnp-3500	74	25	exact	exact	ADJ
fnp-3500	74	26	test	test	NOUN
fnp-3500	74	27	)	)	PUNCT
fnp-3500	74	28	.	.	PUNCT
fnp-3500	75	1	vhl	vhl	NOUN
fnp-3500	75	2	-	-	PUNCT
fnp-3500	75	3	disease	disease	NOUN
fnp-3500	75	4	status	status	NOUN
fnp-3500	75	5	was	be	AUX
fnp-3500	75	6	not	not	PART
fnp-3500	75	7	associated	associate	VERB
fnp-3500	75	8	with	with	ADP
fnp-3500	75	9	an	an	DET
fnp-3500	75	10	increased	increase	VERB
fnp-3500	75	11	risk	risk	NOUN
fnp-3500	75	12	of	of	ADP
fnp-3500	75	13	recurrence	recurrence	NOUN
fnp-3500	75	14	,	,	PUNCT
fnp-3500	75	15	but	but	CCONJ
fnp-3500	75	16	the	the	DET
fnp-3500	75	17	presence	presence	NOUN
fnp-3500	75	18	of	of	ADP
fnp-3500	75	19	clear	clear	ADJ
fnp-3500	75	20	cells	cell	NOUN
fnp-3500	75	21	was	be	AUX
fnp-3500	75	22	found	find	VERB
fnp-3500	75	23	to	to	PART
fnp-3500	75	24	be	be	AUX
fnp-3500	75	25	associated	associate	VERB
fnp-3500	75	26	with	with	ADP
fnp-3500	75	27	shorter	short	ADJ
fnp-3500	75	28	progression	progression	NOUN
fnp-3500	75	29	-	-	PUNCT
fnp-3500	75	30	free	free	ADJ
fnp-3500	75	31	survival	survival	NOUN
fnp-3500	75	32	(	(	PUNCT
fnp-3500	75	33	p	p	X
fnp-3500	75	34	=	=	SYM
fnp-3500	75	35	0.0002	0.0002	NUM
fnp-3500	75	36	,	,	PUNCT
fnp-3500	75	37	log	log	NOUN
fnp-3500	75	38	-	-	PUNCT
fnp-3500	75	39	rank	rank	NOUN
fnp-3500	75	40	test	test	NOUN
fnp-3500	75	41	)	)	PUNCT
fnp-3500	75	42	.	.	PUNCT
fnp-3500	76	1	conclusion	conclusion	NOUN
fnp-3500	76	2	.	.	PUNCT
fnp-3500	77	1	biallelic	biallelic	ADJ
fnp-3500	77	2	inactivation	inactivation	NOUN
fnp-3500	77	3	of	of	ADP
fnp-3500	77	4	vhl	vhl	PROPN
fnp-3500	77	5	is	be	AUX
fnp-3500	77	6	the	the	DET
fnp-3500	77	7	main	main	ADJ
fnp-3500	77	8	mechanism	mechanism	NOUN
fnp-3500	77	9	underlying	underlie	VERB
fnp-3500	77	10	elsts	elst	NOUN
fnp-3500	77	11	,	,	PUNCT
fnp-3500	77	12	but	but	CCONJ
fnp-3500	77	13	unknown	unknown	ADJ
fnp-3500	77	14	mechanisms	mechanism	NOUN
fnp-3500	77	15	beyond	beyond	ADP
fnp-3500	77	16	vhl	vhl	NOUN
fnp-3500	77	17	may	may	AUX
fnp-3500	77	18	rarely	rarely	ADV
fnp-3500	77	19	be	be	AUX
fnp-3500	77	20	involved	involve	VERB
fnp-3500	77	21	in	in	ADP
fnp-3500	77	22	the	the	DET
fnp-3500	77	23	pathogenesis	pathogenesis	NOUN
fnp-3500	77	24	of	of	ADP
fnp-3500	77	25	sporadic	sporadic	ADJ
fnp-3500	77	26	elsts	elst	NOUN
fnp-3500	77	27	.	.	PUNCT
fnp-3500	78	1	fig	fig	NOUN
fnp-3500	78	2	.	.	PUNCT
fnp-3500	79	1	1	1	NUM
fnp-3500	79	2	fig	fig	NOUN
fnp-3500	79	3	.	.	PUNCT
fnp-3500	80	1	2	2	NUM
fnp-3500	80	2	  	  	SPACE
fnp-3500	80	3	noa-03	noa-03	NOUN
fnp-3500	80	4	free	free	ADJ
fnp-3500	80	5	neuropathol	neuropathol	NOUN
fnp-3500	80	6	2:22:12	2:22:12	NUM
fnp-3500	80	7	establishment	establishment	NOUN
fnp-3500	80	8	and	and	CCONJ
fnp-3500	80	9	characterization	characterization	NOUN
fnp-3500	80	10	of	of	ADP
fnp-3500	80	11	a	a	DET
fnp-3500	80	12	meningioma	meningioma	NOUN
fnp-3500	80	13	cell	cell	NOUN
fnp-3500	80	14	model	model	NOUN
fnp-3500	80	15	with	with	ADP
fnp-3500	80	16	ragc	ragc	NOUN
fnp-3500	80	17	knockout	knockout	PROPN
fnp-3500	80	18	r.	r.	PROPN
fnp-3500	80	19	diaz	diaz	PROPN
fnp-3500	80	20	peregrino1	peregrino1	PROPN
fnp-3500	80	21	,	,	PUNCT
fnp-3500	80	22	j.	j.	PROPN
fnp-3500	80	23	kahr1	kahr1	PROPN
fnp-3500	80	24	,	,	PUNCT
fnp-3500	80	25	n.	n.	PROPN
fnp-3500	80	26	waldt1	waldt1	PROPN
fnp-3500	80	27	,	,	PUNCT
fnp-3500	80	28	e.	e.	PROPN
fnp-3500	80	29	kirches1	kirches1	PROPN
fnp-3500	80	30	,	,	PUNCT
fnp-3500	80	31	c.	c.	PROPN
fnp-3500	80	32	mawrin1	mawrin1	PROPN
fnp-3500	80	33	1	1	NUM
fnp-3500	80	34	otto	otto	PROPN
fnp-3500	80	35	-	-	PUNCT
fnp-3500	80	36	von	von	PROPN
fnp-3500	80	37	-	-	PUNCT
fnp-3500	80	38	guericke	guericke	PROPN
fnp-3500	80	39	universität	universität	PROPN
fnp-3500	80	40	magdeburg	magdeburg	PROPN
fnp-3500	80	41	,	,	PUNCT
fnp-3500	80	42	institut	institut	PROPN
fnp-3500	80	43	für	für	PROPN
fnp-3500	80	44	neuropathologie	neuropathologie	PROPN
fnp-3500	80	45	,	,	PUNCT
fnp-3500	80	46	magdeburg	magdeburg	PROPN
fnp-3500	80	47	,	,	PUNCT
fnp-3500	80	48	germany	germany	PROPN
fnp-3500	80	49	amino	amino	PROPN
fnp-3500	80	50	acid	acid	PROPN
fnp-3500	80	51	sensors	sensor	NOUN
fnp-3500	80	52	are	be	AUX
fnp-3500	80	53	essential	essential	ADJ
fnp-3500	80	54	for	for	ADP
fnp-3500	80	55	cell	cell	NOUN
fnp-3500	80	56	growth	growth	NOUN
fnp-3500	80	57	and	and	CCONJ
fnp-3500	80	58	carcinogenesis	carcinogenesis	NOUN
fnp-3500	80	59	via	via	ADP
fnp-3500	80	60	the	the	DET
fnp-3500	80	61	mtorc1	mtorc1	NOUN
fnp-3500	80	62	pathway	pathway	NOUN
fnp-3500	80	63	.	.	PUNCT
fnp-3500	81	1	iomm	iomm	NOUN
fnp-3500	81	2	lee	lee	PROPN
fnp-3500	81	3	cells	cell	NOUN
fnp-3500	81	4	are	be	AUX
fnp-3500	81	5	suitable	suitable	ADJ
fnp-3500	81	6	to	to	PART
fnp-3500	81	7	study	study	VERB
fnp-3500	81	8	the	the	DET
fnp-3500	81	9	meningioma	meningioma	NOUN
fnp-3500	81	10	pathogenesis	pathogenesis	NOUN
fnp-3500	81	11	,	,	PUNCT
fnp-3500	81	12	and	and	CCONJ
fnp-3500	81	13	amino	amino	NOUN
fnp-3500	81	14	acid	acid	NOUN
fnp-3500	81	15	sensors	sensor	NOUN
fnp-3500	81	16	like	like	ADP
fnp-3500	81	17	ragc	ragc	NOUN
fnp-3500	81	18	can	can	AUX
fnp-3500	81	19	be	be	AUX
fnp-3500	81	20	investigated	investigate	VERB
fnp-3500	81	21	in	in	ADP
fnp-3500	81	22	these	these	DET
fnp-3500	81	23	cells	cell	NOUN
fnp-3500	81	24	.	.	PUNCT
fnp-3500	82	1	the	the	DET
fnp-3500	82	2	aims	aim	NOUN
fnp-3500	82	3	of	of	ADP
fnp-3500	82	4	this	this	DET
fnp-3500	82	5	work	work	NOUN
fnp-3500	82	6	are	be	AUX
fnp-3500	82	7	(	(	PUNCT
fnp-3500	82	8	i	i	NOUN
fnp-3500	82	9	)	)	PUNCT
fnp-3500	82	10	generate	generate	VERB
fnp-3500	82	11	a	a	DET
fnp-3500	82	12	meningioma	meningioma	NOUN
fnp-3500	82	13	cell	cell	NOUN
fnp-3500	82	14	line	line	NOUN
fnp-3500	82	15	with	with	ADP
fnp-3500	82	16	ragc	ragc	NOUN
fnp-3500	82	17	deficiency	deficiency	NOUN
fnp-3500	82	18	;	;	PUNCT
fnp-3500	82	19	(	(	PUNCT
fnp-3500	82	20	ii	ii	NOUN
fnp-3500	82	21	)	)	PUNCT
fnp-3500	82	22	determine	determine	VERB
fnp-3500	82	23	its	its	PRON
fnp-3500	82	24	morphology	morphology	NOUN
fnp-3500	82	25	;	;	PUNCT
fnp-3500	82	26	(	(	PUNCT
fnp-3500	82	27	iii	iii	X
fnp-3500	82	28	)	)	PUNCT
fnp-3500	82	29	characterize	characterize	VERB
fnp-3500	82	30	it	it	PRON
fnp-3500	82	31	in	in	ADP
fnp-3500	82	32	vitro	vitro	X
fnp-3500	82	33	using	use	VERB
fnp-3500	82	34	cell	cell	NOUN
fnp-3500	82	35	viability	viability	NOUN
fnp-3500	82	36	assay	assay	VERB
fnp-3500	82	37	,	,	PUNCT
fnp-3500	82	38	trypan	trypan	VERB
fnp-3500	82	39	blue	blue	ADJ
fnp-3500	82	40	cell	cell	NOUN
fnp-3500	82	41	counting	counting	NOUN
fnp-3500	82	42	assay	assay	NOUN
fnp-3500	82	43	,	,	PUNCT
fnp-3500	82	44	colony	colony	NOUN
fnp-3500	82	45	formation	formation	NOUN
fnp-3500	82	46	assay	assay	VERB
fnp-3500	82	47	,	,	PUNCT
fnp-3500	82	48	and	and	CCONJ
fnp-3500	82	49	brdu	brdu	NOUN
fnp-3500	82	50	assay	assay	VERB
fnp-3500	82	51	;	;	PUNCT
fnp-3500	82	52	(	(	PUNCT
fnp-3500	82	53	iv	iv	X
fnp-3500	82	54	)	)	PUNCT
fnp-3500	82	55	and	and	CCONJ
fnp-3500	82	56	measure	measure	VERB
fnp-3500	82	57	its	its	PRON
fnp-3500	82	58	motion	motion	NOUN
fnp-3500	82	59	.	.	PUNCT
fnp-3500	83	1	ragc	ragc	NOUN
fnp-3500	83	2	knockout	knockout	NOUN
fnp-3500	83	3	was	be	AUX
fnp-3500	83	4	achieved	achieve	VERB
fnp-3500	83	5	through	through	ADP
fnp-3500	83	6	crispr	crispr	ADJ
fnp-3500	83	7	-	-	PUNCT
fnp-3500	83	8	cas9	cas9	NOUN
fnp-3500	83	9	system	system	NOUN
fnp-3500	83	10	and	and	CCONJ
fnp-3500	83	11	corroborated	corroborate	VERB
fnp-3500	83	12	by	by	ADP
fnp-3500	83	13	western	western	ADJ
fnp-3500	83	14	blot	blot	NOUN
fnp-3500	83	15	.	.	PUNCT
fnp-3500	84	1	the	the	DET
fnp-3500	84	2	area	area	NOUN
fnp-3500	84	3	and	and	CCONJ
fnp-3500	84	4	circularity	circularity	NOUN
fnp-3500	84	5	of	of	ADP
fnp-3500	84	6	iomm	iomm	NOUN
fnp-3500	84	7	ragcko	ragcko	ADJ
fnp-3500	84	8	and	and	CCONJ
fnp-3500	84	9	iomm	iomm	NOUN
fnp-3500	84	10	scr	scr	NOUN
fnp-3500	84	11	(	(	PUNCT
fnp-3500	84	12	scramble	scramble	VERB
fnp-3500	84	13	control	control	NOUN
fnp-3500	84	14	)	)	PUNCT
fnp-3500	84	15	cells	cell	NOUN
fnp-3500	84	16	were	be	AUX
fnp-3500	84	17	determined	determine	VERB
fnp-3500	84	18	by	by	ADP
fnp-3500	84	19	phalloidin	phalloidin	VERB
fnp-3500	84	20	staining	stain	VERB
fnp-3500	84	21	.	.	PUNCT
fnp-3500	85	1	in	in	ADP
fnp-3500	85	2	vitro	vitro	X
fnp-3500	85	3	assays	assay	NOUN
fnp-3500	85	4	at	at	ADP
fnp-3500	85	5	24	24	NUM
fnp-3500	85	6	and	and	CCONJ
fnp-3500	85	7	48	48	NUM
fnp-3500	85	8	hours	hour	NOUN
fnp-3500	85	9	were	be	AUX
fnp-3500	85	10	performed	perform	VERB
fnp-3500	85	11	to	to	ADP
fnp-3500	85	12	scr	scr	NOUN
fnp-3500	85	13	and	and	CCONJ
fnp-3500	85	14	ragcko	ragcko	ADJ
fnp-3500	85	15	cells	cell	NOUN
fnp-3500	85	16	cultured	cultured	ADJ
fnp-3500	85	17	in	in	ADP
fnp-3500	85	18	normal	normal	ADJ
fnp-3500	85	19	and	and	CCONJ
fnp-3500	85	20	leucine	leucine	NOUN
fnp-3500	85	21	-	-	PUNCT
fnp-3500	85	22	depleted	deplete	VERB
fnp-3500	85	23	medium	medium	NOUN
fnp-3500	85	24	.	.	PUNCT
fnp-3500	86	1	wound	wound	NOUN
fnp-3500	86	2	healing	healing	NOUN
fnp-3500	86	3	assay	assay	NOUN
fnp-3500	86	4	,	,	PUNCT
fnp-3500	86	5	velocity	velocity	NOUN
fnp-3500	86	6	,	,	PUNCT
fnp-3500	86	7	displacement	displacement	NOUN
fnp-3500	86	8	,	,	PUNCT
fnp-3500	86	9	acceleration	acceleration	NOUN
fnp-3500	86	10	,	,	PUNCT
fnp-3500	86	11	and	and	CCONJ
fnp-3500	86	12	percentage	percentage	NOUN
fnp-3500	86	13	of	of	ADP
fnp-3500	86	14	moving	move	VERB
fnp-3500	86	15	cells	cell	NOUN
fnp-3500	86	16	were	be	AUX
fnp-3500	86	17	measured	measure	VERB
fnp-3500	86	18	in	in	ADP
fnp-3500	86	19	both	both	DET
fnp-3500	86	20	cell	cell	NOUN
fnp-3500	86	21	lines	line	NOUN
fnp-3500	86	22	seeded	seed	VERB
fnp-3500	86	23	in	in	ADP
fnp-3500	86	24	the	the	DET
fnp-3500	86	25	standard	standard	ADJ
fnp-3500	86	26	and	and	CCONJ
fnp-3500	86	27	leucine	leucine	NOUN
fnp-3500	86	28	-	-	PUNCT
fnp-3500	86	29	free	free	ADJ
fnp-3500	86	30	medium	medium	NOUN
fnp-3500	86	31	.	.	PUNCT
fnp-3500	87	1	cell	cell	NOUN
fnp-3500	87	2	area	area	NOUN
fnp-3500	87	3	was	be	AUX
fnp-3500	87	4	similar	similar	ADJ
fnp-3500	87	5	between	between	ADP
fnp-3500	87	6	cell	cell	NOUN
fnp-3500	87	7	genotypes	genotype	NOUN
fnp-3500	87	8	,	,	PUNCT
fnp-3500	87	9	but	but	CCONJ
fnp-3500	87	10	ragcko	ragcko	ADJ
fnp-3500	87	11	cells	cell	NOUN
fnp-3500	87	12	were	be	AUX
fnp-3500	87	13	more	more	ADV
fnp-3500	87	14	elongated	elongate	VERB
fnp-3500	87	15	than	than	ADP
fnp-3500	87	16	scr	scr	NOUN
fnp-3500	87	17	cells	cell	NOUN
fnp-3500	87	18	.	.	PUNCT
fnp-3500	88	1	based	base	VERB
fnp-3500	88	2	on	on	ADP
fnp-3500	88	3	cell	cell	NOUN
fnp-3500	88	4	genotype	genotype	NOUN
fnp-3500	88	5	comparison	comparison	NOUN
fnp-3500	88	6	,	,	PUNCT
fnp-3500	88	7	ragcko	ragcko	ADJ
fnp-3500	88	8	cells	cell	NOUN
fnp-3500	88	9	were	be	AUX
fnp-3500	88	10	more	more	ADV
fnp-3500	88	11	metabolically	metabolically	ADV
fnp-3500	88	12	active	active	ADJ
fnp-3500	88	13	and	and	CCONJ
fnp-3500	88	14	displayed	display	VERB
fnp-3500	88	15	more	more	ADJ
fnp-3500	88	16	cell	cell	NOUN
fnp-3500	88	17	proliferation	proliferation	NOUN
fnp-3500	88	18	than	than	ADP
fnp-3500	88	19	scr	scr	NOUN
fnp-3500	88	20	cells	cell	NOUN
fnp-3500	88	21	.	.	PUNCT
fnp-3500	89	1	centered	center	VERB
fnp-3500	89	2	on	on	ADP
fnp-3500	89	3	media	medium	NOUN
fnp-3500	89	4	comparison	comparison	NOUN
fnp-3500	89	5	,	,	PUNCT
fnp-3500	89	6	cell	cell	NOUN
fnp-3500	89	7	numbers	number	NOUN
fnp-3500	89	8	and	and	CCONJ
fnp-3500	89	9	cell	cell	NOUN
fnp-3500	89	10	proliferation	proliferation	NOUN
fnp-3500	89	11	decayed	decay	VERB
fnp-3500	89	12	in	in	ADP
fnp-3500	89	13	both	both	DET
fnp-3500	89	14	cell	cell	NOUN
fnp-3500	89	15	lines	line	NOUN
fnp-3500	89	16	when	when	SCONJ
fnp-3500	89	17	cultivating	cultivate	VERB
fnp-3500	89	18	them	they	PRON
fnp-3500	89	19	in	in	ADP
fnp-3500	89	20	the	the	DET
fnp-3500	89	21	leucine	leucine	NOUN
fnp-3500	89	22	-	-	PUNCT
fnp-3500	89	23	free	free	ADJ
fnp-3500	89	24	medium	medium	NOUN
fnp-3500	89	25	.	.	PUNCT
fnp-3500	90	1	only	only	ADJ
fnp-3500	90	2	ragcko	ragcko	ADJ
fnp-3500	90	3	cells	cell	NOUN
fnp-3500	90	4	had	have	VERB
fnp-3500	90	5	a	a	DET
fnp-3500	90	6	reduction	reduction	NOUN
fnp-3500	90	7	in	in	ADP
fnp-3500	90	8	atp	atp	NOUN
fnp-3500	90	9	production	production	NOUN
fnp-3500	90	10	under	under	ADP
fnp-3500	90	11	leucine	leucine	NOUN
fnp-3500	90	12	withdrawal	withdrawal	NOUN
fnp-3500	90	13	.	.	PUNCT
fnp-3500	91	1	finally	finally	ADV
fnp-3500	91	2	,	,	PUNCT
fnp-3500	91	3	ragcko	ragcko	ADJ
fnp-3500	91	4	cells	cell	NOUN
fnp-3500	91	5	exhibited	exhibit	VERB
fnp-3500	91	6	higher	high	ADJ
fnp-3500	91	7	motility	motility	NOUN
fnp-3500	91	8	than	than	ADP
fnp-3500	91	9	scr	scr	NOUN
fnp-3500	91	10	cells	cell	NOUN
fnp-3500	91	11	judged	judge	VERB
fnp-3500	91	12	by	by	ADP
fnp-3500	91	13	the	the	DET
fnp-3500	91	14	motion	motion	NOUN
fnp-3500	91	15	parameters	parameter	NOUN
fnp-3500	91	16	.	.	PUNCT
fnp-3500	92	1	moreover	moreover	ADV
fnp-3500	92	2	,	,	PUNCT
fnp-3500	92	3	the	the	DET
fnp-3500	92	4	motility	motility	NOUN
fnp-3500	92	5	of	of	ADP
fnp-3500	92	6	ragcko	ragcko	ADJ
fnp-3500	92	7	cells	cell	NOUN
fnp-3500	92	8	was	be	AUX
fnp-3500	92	9	resistant	resistant	ADJ
fnp-3500	92	10	towards	towards	ADP
fnp-3500	92	11	leucine	leucine	NOUN
fnp-3500	92	12	depletion	depletion	NOUN
fnp-3500	92	13	and	and	CCONJ
fnp-3500	92	14	even	even	ADV
fnp-3500	92	15	increased	increase	VERB
fnp-3500	92	16	in	in	ADP
fnp-3500	92	17	comparison	comparison	NOUN
fnp-3500	92	18	to	to	ADP
fnp-3500	92	19	scr	scr	NOUN
fnp-3500	92	20	cells	cell	NOUN
fnp-3500	92	21	.	.	PUNCT
fnp-3500	93	1	ragcko	ragcko	ADJ
fnp-3500	93	2	cells	cell	NOUN
fnp-3500	93	3	displayed	display	VERB
fnp-3500	93	4	increased	increase	VERB
fnp-3500	93	5	proliferation	proliferation	NOUN
fnp-3500	93	6	and	and	CCONJ
fnp-3500	93	7	atp	atp	NOUN
fnp-3500	93	8	production	production	NOUN
fnp-3500	93	9	in	in	ADP
fnp-3500	93	10	leucine	leucine	NOUN
fnp-3500	93	11	-	-	PUNCT
fnp-3500	93	12	supplied	supply	VERB
fnp-3500	93	13	scenarios	scenario	NOUN
fnp-3500	93	14	and	and	CCONJ
fnp-3500	93	15	accelerated	accelerate	VERB
fnp-3500	93	16	migration	migration	NOUN
fnp-3500	93	17	under	under	ADP
fnp-3500	93	18	leucine	leucine	NOUN
fnp-3500	93	19	-	-	PUNCT
fnp-3500	93	20	deprived	deprive	VERB
fnp-3500	93	21	conditions	condition	NOUN
fnp-3500	93	22	.	.	PUNCT
fnp-3500	94	1	changes	change	NOUN
fnp-3500	94	2	in	in	ADP
fnp-3500	94	3	akt	akt	PROPN
fnp-3500	94	4	and	and	CCONJ
fnp-3500	94	5	pp70s6	pp70s6	NOUN
fnp-3500	94	6	signaling	signal	VERB
fnp-3500	94	7	may	may	AUX
fnp-3500	94	8	be	be	AUX
fnp-3500	94	9	involved	involve	VERB
fnp-3500	94	10	in	in	ADP
fnp-3500	94	11	both	both	DET
fnp-3500	94	12	phenomena	phenomenon	NOUN
fnp-3500	94	13	.	.	PUNCT
fnp-3500	95	1	furthermore	furthermore	ADV
fnp-3500	95	2	,	,	PUNCT
fnp-3500	95	3	the	the	DET
fnp-3500	95	4	morphological	morphological	ADJ
fnp-3500	95	5	modifications	modification	NOUN
fnp-3500	95	6	of	of	ADP
fnp-3500	95	7	ragcko	ragcko	ADJ
fnp-3500	95	8	cells	cell	NOUN
fnp-3500	95	9	might	might	AUX
fnp-3500	95	10	enhance	enhance	VERB
fnp-3500	95	11	their	their	PRON
fnp-3500	95	12	motion	motion	NOUN
fnp-3500	95	13	.	.	PUNCT
fnp-3500	95	14	  	  	SPACE
fnp-3500	96	1	noa-04	noa-04	ADV
fnp-3500	96	2	free	free	ADJ
fnp-3500	96	3	neuropathol	neuropathol	NOUN
fnp-3500	96	4	2:22:13	2:22:13	NUM
fnp-3500	96	5	the	the	DET
fnp-3500	96	6	role	role	NOUN
fnp-3500	96	7	of	of	ADP
fnp-3500	96	8	2	2	NUM
fnp-3500	96	9	-	-	PUNCT
fnp-3500	96	10	oxoglutarate	oxoglutarate	ADJ
fnp-3500	96	11	homeostasis	homeostasis	NOUN
fnp-3500	96	12	in	in	ADP
fnp-3500	96	13	tumour	tumour	NOUN
fnp-3500	96	14	invasion	invasion	NOUN
fnp-3500	96	15	and	and	CCONJ
fnp-3500	96	16	metastasis	metastasis	NOUN
fnp-3500	96	17	in	in	ADP
fnp-3500	96	18	glioblastoma	glioblastoma	NOUN
fnp-3500	96	19	a.	a.	PROPN
fnp-3500	96	20	alserw1	alserw1	PROPN
fnp-3500	96	21	,	,	PUNCT
fnp-3500	96	22	n.	n.	NOUN
fnp-3500	96	23	bögürcü	bögürcü	PROPN
fnp-3500	96	24	-	-	PUNCT
fnp-3500	96	25	seidel1	seidel1	PROPN
fnp-3500	96	26	,	,	PUNCT
fnp-3500	96	27	s.	s.	PROPN
fnp-3500	96	28	seidel2	seidel2	PROPN
fnp-3500	96	29	,	,	PUNCT
fnp-3500	96	30	s.	s.	PROPN
fnp-3500	96	31	gräf1	gräf1	PROPN
fnp-3500	96	32	,	,	PUNCT
fnp-3500	96	33	s.	s.	PROPN
fnp-3500	96	34	zukunft3	zukunft3	PROPN
fnp-3500	96	35	,	,	PUNCT
fnp-3500	96	36	i.	i.	PROPN
fnp-3500	96	37	fleming3	fleming3	PROPN
fnp-3500	96	38	,	,	PUNCT
fnp-3500	96	39	s.	s.	PROPN
fnp-3500	96	40	günther4	günther4	PROPN
fnp-3500	96	41	,	,	PUNCT
fnp-3500	96	42	m.	m.	NOUN
fnp-3500	96	43	looso4	looso4	PROPN
fnp-3500	96	44	,	,	PUNCT
fnp-3500	96	45	a.	a.	PROPN
fnp-3500	96	46	németh1	németh1	PROPN
fnp-3500	96	47	,	,	PUNCT
fnp-3500	96	48	b.	b.	PROPN
fnp-3500	96	49	garvalov1,5	garvalov1,5	PROPN
fnp-3500	96	50	,	,	PUNCT
fnp-3500	96	51	t.	t.	PROPN
fnp-3500	96	52	acker1	acker1	PROPN
fnp-3500	96	53	1	1	NUM
fnp-3500	96	54	justus	justus	PROPN
fnp-3500	96	55	-	-	PUNCT
fnp-3500	96	56	liebig	liebig	NOUN
fnp-3500	96	57	-	-	PUNCT
fnp-3500	96	58	university	university	NOUN
fnp-3500	96	59	gießen	gießen	NOUN
fnp-3500	96	60	,	,	PUNCT
fnp-3500	96	61	institute	institute	NOUN
fnp-3500	96	62	for	for	ADP
fnp-3500	96	63	neuropathology	neuropathology	NOUN
fnp-3500	96	64	,	,	PUNCT
fnp-3500	96	65	gießen	gießen	PROPN
fnp-3500	96	66	,	,	PUNCT
fnp-3500	96	67	germany	germany	PROPN
fnp-3500	96	68	2	2	NUM
fnp-3500	96	69	institute	institute	PROPN
fnp-3500	96	70	of	of	ADP
fnp-3500	96	71	cell	cell	NOUN
fnp-3500	96	72	biology	biology	NOUN
fnp-3500	96	73	and	and	CCONJ
fnp-3500	96	74	neuroscience	neuroscience	NOUN
fnp-3500	96	75	and	and	CCONJ
fnp-3500	96	76	buchmann	buchmann	PROPN
fnp-3500	96	77	institute	institute	PROPN
fnp-3500	96	78	for	for	ADP
fnp-3500	96	79	molecular	molecular	ADJ
fnp-3500	96	80	life	life	NOUN
fnp-3500	96	81	sciences	science	NOUN
fnp-3500	96	82	(	(	PUNCT
fnp-3500	96	83	bmls	bmls	NOUN
fnp-3500	96	84	)	)	PUNCT
fnp-3500	96	85	,	,	PUNCT
fnp-3500	96	86	goethe	goethe	PROPN
fnp-3500	96	87	university	university	PROPN
fnp-3500	96	88	,	,	PUNCT
fnp-3500	96	89	frankfurt	frankfurt	PROPN
fnp-3500	96	90	a.	a.	NOUN
fnp-3500	96	91	m.	m.	PROPN
fnp-3500	96	92	,	,	PUNCT
fnp-3500	96	93	germany	germany	PROPN
fnp-3500	96	94	3	3	NUM
fnp-3500	96	95	goethe	goethe	PROPN
fnp-3500	96	96	university	university	PROPN
fnp-3500	96	97	frankfurt	frankfurt	PROPN
fnp-3500	96	98	,	,	PUNCT
fnp-3500	96	99	institute	institute	NOUN
fnp-3500	96	100	for	for	ADP
fnp-3500	96	101	vascular	vascular	ADJ
fnp-3500	96	102	signalling	signalling	NOUN
fnp-3500	96	103	,	,	PUNCT
fnp-3500	96	104	frankfurt	frankfurt	PROPN
fnp-3500	96	105	a.	a.	NOUN
fnp-3500	96	106	m.	m.	PROPN
fnp-3500	96	107	,	,	PUNCT
fnp-3500	96	108	germany	germany	PROPN
fnp-3500	96	109	4	4	NUM
fnp-3500	96	110	max	max	PROPN
fnp-3500	96	111	planck	planck	PROPN
fnp-3500	96	112	institute	institute	PROPN
fnp-3500	96	113	for	for	ADP
fnp-3500	96	114	heart	heart	NOUN
fnp-3500	96	115	and	and	CCONJ
fnp-3500	96	116	lung	lung	NOUN
fnp-3500	96	117	research	research	NOUN
fnp-3500	96	118	,	,	PUNCT
fnp-3500	96	119	bioinformatics	bioinformatics	NOUN
fnp-3500	96	120	core	core	NOUN
fnp-3500	96	121	unit	unit	NOUN
fnp-3500	96	122	(	(	PUNCT
fnp-3500	96	123	m.l	m.l	PROPN
fnp-3500	96	124	.	.	PROPN
fnp-3500	96	125	,	,	PUNCT
fnp-3500	96	126	p.g	p.g	PROPN
fnp-3500	96	127	.	.	PROPN
fnp-3500	96	128	)	)	PUNCT
fnp-3500	96	129	,	,	PUNCT
fnp-3500	96	130	bad	bad	ADJ
fnp-3500	96	131	nauheim	nauheim	PROPN
fnp-3500	96	132	,	,	PUNCT
fnp-3500	96	133	germany	germany	PROPN
fnp-3500	96	134	5	5	NUM
fnp-3500	96	135	european	european	ADJ
fnp-3500	96	136	center	center	NOUN
fnp-3500	96	137	for	for	ADP
fnp-3500	96	138	angioscience	angioscience	NOUN
fnp-3500	96	139	(	(	PUNCT
fnp-3500	96	140	ecas	ecas	PROPN
fnp-3500	96	141	)	)	PUNCT
fnp-3500	96	142	,	,	PUNCT
fnp-3500	96	143	department	department	NOUN
fnp-3500	96	144	of	of	ADP
fnp-3500	96	145	microvascular	microvascular	ADJ
fnp-3500	96	146	biology	biology	NOUN
fnp-3500	96	147	and	and	CCONJ
fnp-3500	96	148	pathobiology	pathobiology	NOUN
fnp-3500	96	149	,	,	PUNCT
fnp-3500	96	150	mannheim	mannheim	PROPN
fnp-3500	96	151	,	,	PUNCT
fnp-3500	96	152	germany	germany	PROPN
fnp-3500	96	153	introduction	introduction	NOUN
fnp-3500	96	154	:	:	PUNCT
fnp-3500	96	155	metabolic	metabolic	NOUN
fnp-3500	96	156	reprogramming	reprogramming	NOUN
fnp-3500	96	157	has	have	AUX
fnp-3500	96	158	been	be	AUX
fnp-3500	96	159	associated	associate	VERB
fnp-3500	96	160	with	with	ADP
fnp-3500	96	161	tumour	tumour	NOUN
fnp-3500	96	162	invasion	invasion	NOUN
fnp-3500	96	163	and	and	CCONJ
fnp-3500	96	164	metastasis	metastasis	NOUN
fnp-3500	96	165	.	.	PUNCT
fnp-3500	97	1	epithelial	epithelial	ADJ
fnp-3500	97	2	/	/	SYM
fnp-3500	97	3	proneural	proneural	ADJ
fnp-3500	97	4	-	-	PUNCT
fnp-3500	97	5	to	to	ADP
fnp-3500	97	6	-	-	PUNCT
fnp-3500	97	7	mesenchymal	mesenchymal	NOUN
fnp-3500	97	8	transition	transition	NOUN
fnp-3500	97	9	(	(	PUNCT
fnp-3500	97	10	emt	emt	NOUN
fnp-3500	97	11	/	/	SYM
fnp-3500	97	12	prmt	prmt	NOUN
fnp-3500	97	13	)	)	PUNCT
fnp-3500	97	14	is	be	AUX
fnp-3500	97	15	a	a	DET
fnp-3500	97	16	key	key	ADJ
fnp-3500	97	17	process	process	NOUN
fnp-3500	97	18	behind	behind	ADP
fnp-3500	97	19	cancer	cancer	NOUN
fnp-3500	97	20	cell	cell	NOUN
fnp-3500	97	21	dissemination	dissemination	NOUN
fnp-3500	97	22	,	,	PUNCT
fnp-3500	97	23	which	which	PRON
fnp-3500	97	24	is	be	AUX
fnp-3500	97	25	regulated	regulate	VERB
fnp-3500	97	26	by	by	ADP
fnp-3500	97	27	several	several	ADJ
fnp-3500	97	28	transcription	transcription	NOUN
fnp-3500	97	29	factors	factor	NOUN
fnp-3500	97	30	,	,	PUNCT
fnp-3500	97	31	including	include	VERB
fnp-3500	97	32	snail	snail	NOUN
fnp-3500	97	33	.	.	PUNCT
fnp-3500	98	1	2	2	NUM
fnp-3500	98	2	-	-	NUM
fnp-3500	98	3	oxoglutarate	oxoglutarate	ADJ
fnp-3500	98	4	(	(	PUNCT
fnp-3500	98	5	2	2	NUM
fnp-3500	98	6	-	-	PUNCT
fnp-3500	98	7	og	og	NOUN
fnp-3500	98	8	)	)	PUNCT
fnp-3500	98	9	is	be	AUX
fnp-3500	98	10	a	a	DET
fnp-3500	98	11	metabolite	metabolite	NOUN
fnp-3500	98	12	whose	whose	DET
fnp-3500	98	13	intracellular	intracellular	ADJ
fnp-3500	98	14	level	level	NOUN
fnp-3500	98	15	depends	depend	VERB
fnp-3500	98	16	on	on	ADP
fnp-3500	98	17	the	the	DET
fnp-3500	98	18	activity	activity	NOUN
fnp-3500	98	19	of	of	ADP
fnp-3500	98	20	isocitrate	isocitrate	ADJ
fnp-3500	98	21	dehydrogenase	dehydrogenase	NOUN
fnp-3500	98	22	1	1	NUM
fnp-3500	98	23	(	(	PUNCT
fnp-3500	98	24	idh1	idh1	PROPN
fnp-3500	98	25	)	)	PUNCT
fnp-3500	98	26	.	.	PUNCT
fnp-3500	99	1	the	the	DET
fnp-3500	99	2	metabolite	metabolite	NOUN
fnp-3500	99	3	acts	act	VERB
fnp-3500	99	4	as	as	ADP
fnp-3500	99	5	a	a	DET
fnp-3500	99	6	co	co	NOUN
fnp-3500	99	7	-	-	NOUN
fnp-3500	99	8	substrate	substrate	NOUN
fnp-3500	99	9	for	for	ADP
fnp-3500	99	10	2	2	NUM
fnp-3500	99	11	-	-	PUNCT
fnp-3500	99	12	og	og	ADJ
fnp-3500	99	13	-	-	PUNCT
fnp-3500	99	14	dependent	dependent	ADJ
fnp-3500	99	15	dioxygenases	dioxygenase	NOUN
fnp-3500	99	16	(	(	PUNCT
fnp-3500	99	17	2	2	NUM
fnp-3500	99	18	-	-	PUNCT
fnp-3500	99	19	ogdds	ogdd	NOUN
fnp-3500	99	20	)	)	PUNCT
fnp-3500	99	21	which	which	PRON
fnp-3500	99	22	regulate	regulate	VERB
fnp-3500	99	23	different	different	ADJ
fnp-3500	99	24	cellular	cellular	ADJ
fnp-3500	99	25	activities	activity	NOUN
fnp-3500	99	26	.	.	PUNCT
fnp-3500	100	1	while	while	SCONJ
fnp-3500	100	2	mutant	mutant	ADJ
fnp-3500	100	3	-	-	PUNCT
fnp-3500	100	4	idh	idh	NOUN
fnp-3500	100	5	-	-	PUNCT
fnp-3500	100	6	induced	induced	ADJ
fnp-3500	100	7	,	,	PUNCT
fnp-3500	100	8	2	2	NUM
fnp-3500	100	9	-	-	PUNCT
fnp-3500	100	10	ogdd	ogdd	NOUN
fnp-3500	100	11	-	-	PUNCT
fnp-3500	100	12	dependent	dependent	ADJ
fnp-3500	100	13	tumorigenic	tumorigenic	ADJ
fnp-3500	100	14	mechanisms	mechanism	NOUN
fnp-3500	100	15	have	have	AUX
fnp-3500	100	16	been	be	AUX
fnp-3500	100	17	described	describe	VERB
fnp-3500	100	18	in	in	ADP
fnp-3500	100	19	detail	detail	NOUN
fnp-3500	100	20	,	,	PUNCT
fnp-3500	100	21	it	it	PRON
fnp-3500	100	22	is	be	AUX
fnp-3500	100	23	less	less	ADV
fnp-3500	100	24	well	well	ADV
fnp-3500	100	25	understood	understand	VERB
fnp-3500	100	26	how	how	SCONJ
fnp-3500	100	27	wildtype	wildtype	NOUN
fnp-3500	100	28	idh	idh	NOUN
fnp-3500	100	29	and	and	CCONJ
fnp-3500	100	30	2	2	NUM
fnp-3500	100	31	-	-	PUNCT
fnp-3500	100	32	og	og	PROPN
fnp-3500	100	33	levels	level	NOUN
fnp-3500	100	34	control	control	VERB
fnp-3500	100	35	emt	emt	NOUN
fnp-3500	100	36	and	and	CCONJ
fnp-3500	100	37	invasion	invasion	NOUN
fnp-3500	100	38	.	.	PUNCT
fnp-3500	101	1	objectives	objective	NOUN
fnp-3500	101	2	:	:	PUNCT
fnp-3500	101	3	we	we	PRON
fnp-3500	101	4	aim	aim	VERB
fnp-3500	101	5	to	to	PART
fnp-3500	101	6	define	define	VERB
fnp-3500	101	7	the	the	DET
fnp-3500	101	8	homeostatic	homeostatic	ADJ
fnp-3500	101	9	function	function	NOUN
fnp-3500	101	10	of	of	ADP
fnp-3500	101	11	idh1	idh1	NOUN
fnp-3500	101	12	and	and	CCONJ
fnp-3500	101	13	2	2	NUM
fnp-3500	101	14	-	-	NUM
fnp-3500	101	15	og	og	PROPN
fnp-3500	101	16	in	in	ADP
fnp-3500	101	17	the	the	DET
fnp-3500	101	18	regulation	regulation	NOUN
fnp-3500	101	19	of	of	ADP
fnp-3500	101	20	emt	emt	NOUN
fnp-3500	101	21	and	and	CCONJ
fnp-3500	101	22	tumour	tumour	NOUN
fnp-3500	101	23	progression	progression	NOUN
fnp-3500	101	24	primarily	primarily	ADV
fnp-3500	101	25	in	in	ADP
fnp-3500	101	26	glioblastoma	glioblastoma	NOUN
fnp-3500	101	27	,	,	PUNCT
fnp-3500	101	28	as	as	ADV
fnp-3500	101	29	well	well	ADV
fnp-3500	101	30	as	as	ADP
fnp-3500	101	31	in	in	ADP
fnp-3500	101	32	breast	breast	NOUN
fnp-3500	101	33	and	and	CCONJ
fnp-3500	101	34	lung	lung	NOUN
fnp-3500	101	35	cancer	cancer	NOUN
fnp-3500	101	36	models	model	NOUN
fnp-3500	101	37	.	.	PUNCT
fnp-3500	102	1	materials	material	NOUN
fnp-3500	102	2	and	and	CCONJ
fnp-3500	102	3	methods	method	NOUN
fnp-3500	102	4	:	:	PUNCT
fnp-3500	102	5	boyden	boyden	PROPN
fnp-3500	102	6	chamber	chamber	PROPN
fnp-3500	102	7	,	,	PUNCT
fnp-3500	102	8	western	western	ADJ
fnp-3500	102	9	blot	blot	NOUN
fnp-3500	102	10	,	,	PUNCT
fnp-3500	102	11	if	if	SCONJ
fnp-3500	102	12	,	,	PUNCT
fnp-3500	102	13	rt	rt	NOUN
fnp-3500	102	14	-	-	PUNCT
fnp-3500	102	15	qpcr	qpcr	ADJ
fnp-3500	102	16	,	,	PUNCT
fnp-3500	102	17	rnaseq	rnaseq	NOUN
fnp-3500	102	18	and	and	CCONJ
fnp-3500	102	19	metabolite	metabolite	NOUN
fnp-3500	102	20	ms	ms	ADJ
fnp-3500	102	21	assays	assay	NOUN
fnp-3500	102	22	are	be	AUX
fnp-3500	102	23	employed	employ	VERB
fnp-3500	102	24	to	to	PART
fnp-3500	102	25	determine	determine	VERB
fnp-3500	102	26	the	the	DET
fnp-3500	102	27	role	role	NOUN
fnp-3500	102	28	of	of	ADP
fnp-3500	102	29	idh1	idh1	NOUN
fnp-3500	102	30	and	and	CCONJ
fnp-3500	102	31	2	2	NUM
fnp-3500	102	32	-	-	PUNCT
fnp-3500	102	33	og	og	PROPN
fnp-3500	102	34	levels	level	NOUN
fnp-3500	102	35	on	on	ADP
fnp-3500	102	36	emt	emt	PROPN
fnp-3500	102	37	regulators	regulator	NOUN
fnp-3500	102	38	and	and	CCONJ
fnp-3500	102	39	cell	cell	NOUN
fnp-3500	102	40	invasion	invasion	NOUN
fnp-3500	102	41	.	.	PUNCT
fnp-3500	103	1	idh1	idh1	PROPN
fnp-3500	103	2	knockdown	knockdown	PROPN
fnp-3500	103	3	and	and	CCONJ
fnp-3500	103	4	several	several	ADJ
fnp-3500	103	5	functional	functional	ADJ
fnp-3500	103	6	assays	assay	NOUN
fnp-3500	103	7	are	be	AUX
fnp-3500	103	8	used	use	VERB
fnp-3500	103	9	to	to	PART
fnp-3500	103	10	further	far	ADV
fnp-3500	103	11	explore	explore	VERB
fnp-3500	103	12	the	the	DET
fnp-3500	103	13	underlying	underlie	VERB
fnp-3500	103	14	mechanisms	mechanism	NOUN
fnp-3500	103	15	.	.	PUNCT
fnp-3500	104	1	results	result	NOUN
fnp-3500	104	2	:	:	PUNCT
fnp-3500	104	3	we	we	PRON
fnp-3500	104	4	observed	observe	VERB
fnp-3500	104	5	that	that	SCONJ
fnp-3500	104	6	tgfβ	tgfβ	ADV
fnp-3500	104	7	;	;	PUNCT
fnp-3500	104	8	an	an	DET
fnp-3500	104	9	established	establish	VERB
fnp-3500	104	10	emt	emt	NOUN
fnp-3500	104	11	inducer	inducer	NOUN
fnp-3500	104	12	results	result	NOUN
fnp-3500	104	13	in	in	ADP
fnp-3500	104	14	idh1	idh1	NOUN
fnp-3500	104	15	downregulation	downregulation	NOUN
fnp-3500	104	16	,	,	PUNCT
fnp-3500	104	17	with	with	ADP
fnp-3500	104	18	a	a	DET
fnp-3500	104	19	concomitant	concomitant	ADJ
fnp-3500	104	20	increase	increase	NOUN
fnp-3500	104	21	in	in	ADP
fnp-3500	104	22	snail	snail	NOUN
fnp-3500	104	23	expression	expression	NOUN
fnp-3500	104	24	and	and	CCONJ
fnp-3500	104	25	invasion	invasion	NOUN
fnp-3500	104	26	.	.	PUNCT
fnp-3500	105	1	strikingly	strikingly	ADV
fnp-3500	105	2	,	,	PUNCT
fnp-3500	105	3	2	2	NUM
fnp-3500	105	4	-	-	PUNCT
fnp-3500	105	5	og	og	PROPN
fnp-3500	105	6	supplementation	supplementation	NOUN
fnp-3500	105	7	reverts	revert	VERB
fnp-3500	105	8	tgfβ	tgfβ	NOUN
fnp-3500	105	9	induced	induce	VERB
fnp-3500	105	10	snail	snail	NOUN
fnp-3500	105	11	at	at	ADP
fnp-3500	105	12	the	the	DET
fnp-3500	105	13	mrna	mrna	NOUN
fnp-3500	105	14	and	and	CCONJ
fnp-3500	105	15	protein	protein	NOUN
fnp-3500	105	16	level	level	NOUN
fnp-3500	105	17	as	as	ADV
fnp-3500	105	18	well	well	ADV
fnp-3500	105	19	as	as	ADP
fnp-3500	105	20	cellular	cellular	ADJ
fnp-3500	105	21	invasion	invasion	NOUN
fnp-3500	105	22	in	in	ADP
fnp-3500	105	23	vitro	vitro	VERB
fnp-3500	105	24	.	.	PUNCT
fnp-3500	106	1	in	in	ADP
fnp-3500	106	2	line	line	NOUN
fnp-3500	106	3	with	with	ADP
fnp-3500	106	4	a	a	DET
fnp-3500	106	5	functional	functional	ADJ
fnp-3500	106	6	role	role	NOUN
fnp-3500	106	7	of	of	ADP
fnp-3500	106	8	idh1	idh1	PROPN
fnp-3500	106	9	in	in	ADP
fnp-3500	106	10	emt	emt	PROPN
fnp-3500	106	11	,	,	PUNCT
fnp-3500	106	12	idh1deficiency	idh1deficiency	PROPN
fnp-3500	106	13	promotes	promote	VERB
fnp-3500	106	14	invasion	invasion	NOUN
fnp-3500	106	15	and	and	CCONJ
fnp-3500	106	16	metastasis	metastasis	NOUN
fnp-3500	106	17	and	and	CCONJ
fnp-3500	106	18	enhances	enhance	VERB
fnp-3500	106	19	a	a	DET
fnp-3500	106	20	cancer	cancer	NOUN
fnp-3500	106	21	stem	stem	NOUN
fnp-3500	106	22	cell	cell	NOUN
fnp-3500	106	23	phenotype	phenotype	NOUN
fnp-3500	106	24	.	.	PUNCT
fnp-3500	107	1	importantly	importantly	ADV
fnp-3500	107	2	,	,	PUNCT
fnp-3500	107	3	we	we	PRON
fnp-3500	107	4	identify	identify	VERB
fnp-3500	107	5	hif	hif	PROPN
fnp-3500	107	6	and	and	CCONJ
fnp-3500	107	7	mtor	mtor	PROPN
fnp-3500	107	8	signalling	signal	VERB
fnp-3500	107	9	as	as	ADP
fnp-3500	107	10	two	two	NUM
fnp-3500	107	11	crucial	crucial	ADJ
fnp-3500	107	12	mechanistic	mechanistic	ADJ
fnp-3500	107	13	pathways	pathway	NOUN
fnp-3500	107	14	involved	involve	VERB
fnp-3500	107	15	in	in	ADP
fnp-3500	107	16	snail	snail	NOUN
fnp-3500	107	17	regulation	regulation	NOUN
fnp-3500	107	18	by	by	ADP
fnp-3500	107	19	2	2	NUM
fnp-3500	107	20	-	-	PUNCT
fnp-3500	107	21	og	og	PROPN
fnp-3500	107	22	.	.	PUNCT
fnp-3500	107	23	conclusion	conclusion	NOUN
fnp-3500	107	24	:	:	PUNCT
fnp-3500	107	25	collectively	collectively	ADV
fnp-3500	107	26	,	,	PUNCT
fnp-3500	107	27	our	our	PRON
fnp-3500	107	28	findings	finding	NOUN
fnp-3500	107	29	emphasize	emphasize	VERB
fnp-3500	107	30	the	the	DET
fnp-3500	107	31	interplay	interplay	NOUN
fnp-3500	107	32	between	between	ADP
fnp-3500	107	33	metabolism	metabolism	NOUN
fnp-3500	107	34	and	and	CCONJ
fnp-3500	107	35	metastasis	metastasis	NOUN
fnp-3500	107	36	and	and	CCONJ
fnp-3500	107	37	reveal	reveal	VERB
fnp-3500	107	38	novel	novel	ADJ
fnp-3500	107	39	mechanistic	mechanistic	ADJ
fnp-3500	107	40	insights	insight	NOUN
fnp-3500	107	41	into	into	ADP
fnp-3500	107	42	the	the	DET
fnp-3500	107	43	role	role	NOUN
fnp-3500	107	44	of	of	ADP
fnp-3500	107	45	wildtype	wildtype	NOUN
fnp-3500	107	46	idh	idh	NOUN
fnp-3500	107	47	and	and	CCONJ
fnp-3500	107	48	intracellular	intracellular	ADJ
fnp-3500	107	49	2	2	NUM
fnp-3500	107	50	-	-	PUNCT
fnp-3500	107	51	og	og	PROPN
fnp-3500	107	52	levels	level	NOUN
fnp-3500	107	53	in	in	ADP
fnp-3500	107	54	the	the	DET
fnp-3500	107	55	metabolic	metabolic	NOUN
fnp-3500	107	56	control	control	NOUN
fnp-3500	107	57	of	of	ADP
fnp-3500	107	58	tumor	tumor	NOUN
fnp-3500	107	59	invasion	invasion	NOUN
fnp-3500	107	60	and	and	CCONJ
fnp-3500	107	61	emt	emt	PROPN
fnp-3500	107	62	/	/	SYM
fnp-3500	107	63	prmt	prmt	NOUN
fnp-3500	107	64	.	.	PUNCT
fnp-3500	107	65	  	  	SPACE
fnp-3500	108	1	noa-05	noa-05	NUM
fnp-3500	108	2	free	free	ADJ
fnp-3500	108	3	neuropathol	neuropathol	NOUN
fnp-3500	108	4	2:22:14	2:22:14	NUM
fnp-3500	108	5	infratentorial	infratentorial	ADJ
fnp-3500	108	6	idh	idh	NOUN
fnp-3500	108	7	mutant	mutant	NOUN
fnp-3500	108	8	astrocytoma	astrocytoma	NOUN
fnp-3500	108	9	is	be	AUX
fnp-3500	108	10	a	a	DET
fnp-3500	108	11	distinct	distinct	ADJ
fnp-3500	108	12	subtype	subtype	NOUN
fnp-3500	108	13	r.	r.	PROPN
fnp-3500	108	14	banan1	banan1	PROPN
fnp-3500	108	15	,	,	PUNCT
fnp-3500	108	16	d.	d.	PROPN
fnp-3500	108	17	stichel1	stichel1	PROPN
fnp-3500	108	18	,	,	PUNCT
fnp-3500	108	19	a.	a.	NOUN
fnp-3500	108	20	bleck2	bleck2	PROPN
fnp-3500	108	21	,	,	PUNCT
fnp-3500	108	22	b.	b.	PROPN
fnp-3500	109	1	hong3	hong3	PROPN
fnp-3500	109	2	,	,	PUNCT
fnp-3500	109	3	u.	u.	PROPN
fnp-3500	109	4	lehmann4	lehmann4	PROPN
fnp-3500	109	5	,	,	PUNCT
fnp-3500	109	6	a.	a.	PROPN
fnp-3500	109	7	suwala1	suwala1	PROPN
fnp-3500	109	8	,	,	PUNCT
fnp-3500	109	9	a.	a.	PROPN
fnp-3500	109	10	reinhardt1	reinhardt1	PROPN
fnp-3500	109	11	,	,	PUNCT
fnp-3500	109	12	d.	d.	PROPN
fnp-3500	109	13	schrimpf1	schrimpf1	PROPN
fnp-3500	109	14	,	,	PUNCT
fnp-3500	109	15	r.	r.	PROPN
fnp-3500	109	16	buslei5	buslei5	PROPN
fnp-3500	109	17	,	,	PUNCT
fnp-3500	109	18	c.	c.	PROPN
fnp-3500	109	19	stadelmann	stadelmann	PROPN
fnp-3500	109	20	-	-	PUNCT
fnp-3500	109	21	nessler6	nessler6	PROPN
fnp-3500	109	22	,	,	PUNCT
fnp-3500	109	23	k.	k.	PROPN
fnp-3500	110	1	ehlert7	ehlert7	PROPN
fnp-3500	110	2	,	,	PUNCT
fnp-3500	110	3	m.	m.	NOUN
fnp-3500	110	4	prinz8	prinz8	PROPN
fnp-3500	110	5	,	,	PUNCT
fnp-3500	110	6	t.	t.	PROPN
fnp-3500	110	7	acker9	acker9	PROPN
fnp-3500	110	8	,	,	PUNCT
fnp-3500	110	9	j.	j.	PROPN
fnp-3500	110	10	schittenhelm10	schittenhelm10	PROPN
fnp-3500	110	11	,	,	PUNCT
fnp-3500	110	12	d.	d.	PROPN
fnp-3500	110	13	kaul11	kaul11	PROPN
fnp-3500	110	14	,	,	PUNCT
fnp-3500	110	15	l.	l.	PROPN
fnp-3500	110	16	schweizer12	schweizer12	PROPN
fnp-3500	110	17	,	,	PUNCT
fnp-3500	110	18	d.	d.	PROPN
fnp-3500	110	19	capper12	capper12	PROPN
fnp-3500	110	20	,	,	PUNCT
fnp-3500	110	21	p.	p.	PROPN
fnp-3500	110	22	n.	n.	PROPN
fnp-3500	110	23	harter13	harter13	PROPN
fnp-3500	110	24	,	,	PUNCT
fnp-3500	110	25	n.	n.	NOUN
fnp-3500	110	26	etminan14	etminan14	PROPN
fnp-3500	110	27	,	,	PUNCT
fnp-3500	110	28	d.	d.	PROPN
fnp-3500	110	29	t.	t.	PROPN
fnp-3500	110	30	w.	w.	PROPN
fnp-3500	110	31	jones15	jones15	PROPN
fnp-3500	110	32	,	,	PUNCT
fnp-3500	110	33	s.	s.	PROPN
fnp-3500	110	34	m.	m.	PROPN
fnp-3500	110	35	pfister16	pfister16	PROPN
fnp-3500	110	36	,	,	PUNCT
fnp-3500	110	37	c.	c.	PROPN
fnp-3500	110	38	herold	herold	PROPN
fnp-3500	110	39	mende17	mende17	PROPN
fnp-3500	110	40	,	,	PUNCT
fnp-3500	110	41	w.	w.	PROPN
fnp-3500	110	42	wick18	wick18	PROPN
fnp-3500	110	43	,	,	PUNCT
fnp-3500	110	44	f.	f.	PROPN
fnp-3500	110	45	sahm1	sahm1	PROPN
fnp-3500	110	46	,	,	PUNCT
fnp-3500	110	47	a.	a.	PROPN
fnp-3500	110	48	von	von	PROPN
fnp-3500	110	49	deimling1	deimling1	PROPN
fnp-3500	110	50	,	,	PUNCT
fnp-3500	110	51	c.	c.	PROPN
fnp-3500	110	52	hartmann2	hartmann2	PROPN
fnp-3500	110	53	,	,	PUNCT
fnp-3500	110	54	d.	d.	PROPN
fnp-3500	110	55	e.	e.	PROPN
fnp-3500	110	56	reuss1	reuss1	PROPN
fnp-3500	110	57	1	1	NUM
fnp-3500	110	58	heidelberg	heidelberg	PROPN
fnp-3500	110	59	university	university	NOUN
fnp-3500	110	60	hospital	hospital	NOUN
fnp-3500	110	61	,	,	PUNCT
fnp-3500	110	62	department	department	NOUN
fnp-3500	110	63	of	of	ADP
fnp-3500	110	64	neuropathology	neuropathology	NOUN
fnp-3500	110	65	,	,	PUNCT
fnp-3500	110	66	institute	institute	PROPN
fnp-3500	110	67	of	of	ADP
fnp-3500	110	68	pathology	pathology	PROPN
fnp-3500	110	69	,	,	PUNCT
fnp-3500	110	70	heidelberg	heidelberg	PROPN
fnp-3500	110	71	,	,	PUNCT
fnp-3500	110	72	germany	germany	PROPN
fnp-3500	110	73	2	2	NUM
fnp-3500	110	74	hannover	hannover	PROPN
fnp-3500	110	75	medical	medical	ADJ
fnp-3500	110	76	school	school	NOUN
fnp-3500	110	77	(	(	PUNCT
fnp-3500	110	78	mhh	mhh	PROPN
fnp-3500	110	79	)	)	PUNCT
fnp-3500	110	80	,	,	PUNCT
fnp-3500	110	81	department	department	NOUN
fnp-3500	110	82	of	of	ADP
fnp-3500	110	83	neuropathology	neuropathology	NOUN
fnp-3500	110	84	,	,	PUNCT
fnp-3500	110	85	institute	institute	PROPN
fnp-3500	110	86	of	of	ADP
fnp-3500	110	87	pathology	pathology	PROPN
fnp-3500	110	88	,	,	PUNCT
fnp-3500	110	89	hannover	hannover	PROPN
fnp-3500	110	90	,	,	PUNCT
fnp-3500	110	91	germany	germany	PROPN
fnp-3500	110	92	3	3	NUM
fnp-3500	110	93	hannover	hannover	PROPN
fnp-3500	110	94	medical	medical	PROPN
fnp-3500	110	95	school	school	PROPN
fnp-3500	110	96	(	(	PUNCT
fnp-3500	110	97	mhh	mhh	PROPN
fnp-3500	110	98	)	)	PUNCT
fnp-3500	110	99	,	,	PUNCT
fnp-3500	110	100	department	department	NOUN
fnp-3500	110	101	of	of	ADP
fnp-3500	110	102	neurosurgery	neurosurgery	NOUN
fnp-3500	110	103	,	,	PUNCT
fnp-3500	110	104	hannover	hannover	PROPN
fnp-3500	110	105	,	,	PUNCT
fnp-3500	110	106	germany	germany	PROPN
fnp-3500	110	107	4	4	NUM
fnp-3500	110	108	hannover	hannover	PROPN
fnp-3500	110	109	medical	medical	ADJ
fnp-3500	110	110	school	school	NOUN
fnp-3500	110	111	(	(	PUNCT
fnp-3500	110	112	mhh	mhh	PROPN
fnp-3500	110	113	)	)	PUNCT
fnp-3500	110	114	,	,	PUNCT
fnp-3500	110	115	institute	institute	NOUN
fnp-3500	110	116	of	of	ADP
fnp-3500	110	117	pathology	pathology	PROPN
fnp-3500	110	118	,	,	PUNCT
fnp-3500	110	119	hannover	hannover	PROPN
fnp-3500	110	120	,	,	PUNCT
fnp-3500	110	121	germany	germany	PROPN
fnp-3500	110	122	5	5	NUM
fnp-3500	110	123	klinikum	klinikum	PROPN
fnp-3500	110	124	bamberg	bamberg	PROPN
fnp-3500	110	125	,	,	PUNCT
fnp-3500	110	126	institute	institute	PROPN
fnp-3500	110	127	of	of	ADP
fnp-3500	110	128	pathology	pathology	PROPN
fnp-3500	110	129	,	,	PUNCT
fnp-3500	110	130	bamberg	bamberg	PROPN
fnp-3500	110	131	,	,	PUNCT
fnp-3500	110	132	germany	germany	PROPN
fnp-3500	110	133	6	6	NUM
fnp-3500	110	134	university	university	PROPN
fnp-3500	110	135	medical	medical	ADJ
fnp-3500	110	136	center	center	NOUN
fnp-3500	110	137	göttingen	göttingen	NOUN
fnp-3500	110	138	,	,	PUNCT
fnp-3500	110	139	institute	institute	NOUN
fnp-3500	110	140	of	of	ADP
fnp-3500	110	141	neuropathology	neuropathology	NOUN
fnp-3500	110	142	,	,	PUNCT
fnp-3500	110	143	göttingen	göttingen	PROPN
fnp-3500	110	144	,	,	PUNCT
fnp-3500	110	145	germany	germany	PROPN
fnp-3500	110	146	7	7	NUM
fnp-3500	110	147	university	university	PROPN
fnp-3500	110	148	of	of	ADP
fnp-3500	110	149	greifswald	greifswald	PROPN
fnp-3500	110	150	,	,	PUNCT
fnp-3500	110	151	department	department	NOUN
fnp-3500	110	152	of	of	ADP
fnp-3500	110	153	pediatric	pediatric	ADJ
fnp-3500	110	154	oncology	oncology	NOUN
fnp-3500	110	155	and	and	CCONJ
fnp-3500	110	156	hematology	hematology	NOUN
fnp-3500	110	157	,	,	PUNCT
fnp-3500	110	158	greifswald	greifswald	PROPN
fnp-3500	110	159	,	,	PUNCT
fnp-3500	110	160	germany	germany	PROPN
fnp-3500	110	161	8	8	NUM
fnp-3500	110	162	university	university	PROPN
fnp-3500	110	163	of	of	ADP
fnp-3500	110	164	freiburg	freiburg	PROPN
fnp-3500	110	165	,	,	PUNCT
fnp-3500	110	166	institute	institute	NOUN
fnp-3500	110	167	of	of	ADP
fnp-3500	110	168	neuropathology	neuropathology	NOUN
fnp-3500	110	169	,	,	PUNCT
fnp-3500	110	170	freiburg	freiburg	PROPN
fnp-3500	110	171	i.	i.	PROPN
fnp-3500	110	172	br	br	PROPN
fnp-3500	110	173	.	.	PROPN
fnp-3500	110	174	,	,	PUNCT
fnp-3500	110	175	germany	germany	PROPN
fnp-3500	110	176	9	9	NUM
fnp-3500	110	177	institute	institute	PROPN
fnp-3500	110	178	of	of	ADP
fnp-3500	110	179	neuropathology	neuropathology	NOUN
fnp-3500	110	180	,	,	PUNCT
fnp-3500	110	181	university	university	NOUN
fnp-3500	110	182	of	of	ADP
fnp-3500	110	183	gießen	gießen	PROPN
fnp-3500	110	184	,	,	PUNCT
fnp-3500	110	185	gießen	gießen	PROPN
fnp-3500	110	186	,	,	PUNCT
fnp-3500	110	187	germany	germany	PROPN
fnp-3500	110	188	10	10	NUM
fnp-3500	110	189	university	university	PROPN
fnp-3500	110	190	hospital	hospital	NOUN
fnp-3500	110	191	tübingen	tübingen	PROPN
fnp-3500	110	192	,	,	PUNCT
fnp-3500	110	193	department	department	NOUN
fnp-3500	110	194	of	of	ADP
fnp-3500	110	195	neuropathology	neuropathology	NOUN
fnp-3500	110	196	,	,	PUNCT
fnp-3500	110	197	tübingen	tübingen	PROPN
fnp-3500	110	198	,	,	PUNCT
fnp-3500	110	199	germany	germany	PROPN
fnp-3500	110	200	11	11	NUM
fnp-3500	110	201	charité	charité	PROPN
fnp-3500	110	202	–	–	PUNCT
fnp-3500	110	203	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	110	204	berlin	berlin	PROPN
fnp-3500	110	205	,	,	PUNCT
fnp-3500	110	206	department	department	NOUN
fnp-3500	110	207	of	of	ADP
fnp-3500	110	208	radiation	radiation	NOUN
fnp-3500	110	209	oncology	oncology	NOUN
fnp-3500	110	210	and	and	CCONJ
fnp-3500	110	211	radiotherapy	radiotherapy	NOUN
fnp-3500	110	212	,	,	PUNCT
fnp-3500	110	213	berlin	berlin	PROPN
fnp-3500	110	214	,	,	PUNCT
fnp-3500	110	215	germany	germany	PROPN
fnp-3500	110	216	12	12	NUM
fnp-3500	110	217	charité	charité	PROPN
fnp-3500	110	218	–	–	PUNCT
fnp-3500	110	219	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	110	220	berlin	berlin	PROPN
fnp-3500	110	221	,	,	PUNCT
fnp-3500	110	222	department	department	NOUN
fnp-3500	110	223	of	of	ADP
fnp-3500	110	224	neuropathology	neuropathology	NOUN
fnp-3500	110	225	,	,	PUNCT
fnp-3500	110	226	berlin	berlin	PROPN
fnp-3500	110	227	,	,	PUNCT
fnp-3500	110	228	germany	germany	PROPN
fnp-3500	110	229	13	13	NUM
fnp-3500	110	230	goethe	goethe	PROPN
fnp-3500	110	231	university	university	PROPN
fnp-3500	110	232	frankfurt	frankfurt	PROPN
fnp-3500	110	233	,	,	PUNCT
fnp-3500	110	234	institute	institute	PROPN
fnp-3500	110	235	of	of	ADP
fnp-3500	110	236	neurology	neurology	NOUN
fnp-3500	110	237	(	(	PUNCT
fnp-3500	110	238	edinger	edinger	PROPN
fnp-3500	110	239	institute	institute	PROPN
fnp-3500	110	240	)	)	PUNCT
fnp-3500	110	241	,	,	PUNCT
fnp-3500	110	242	frankfurt	frankfurt	PROPN
fnp-3500	110	243	a.	a.	NOUN
fnp-3500	110	244	m.	m.	PROPN
fnp-3500	110	245	,	,	PUNCT
fnp-3500	110	246	germany	germany	PROPN
fnp-3500	110	247	14	14	NUM
fnp-3500	110	248	university	university	PROPN
fnp-3500	110	249	hospital	hospital	NOUN
fnp-3500	110	250	mannheim	mannheim	PROPN
fnp-3500	110	251	,	,	PUNCT
fnp-3500	110	252	university	university	NOUN
fnp-3500	110	253	of	of	ADP
fnp-3500	110	254	heidelberg	heidelberg	PROPN
fnp-3500	110	255	,	,	PUNCT
fnp-3500	110	256	department	department	NOUN
fnp-3500	110	257	of	of	ADP
fnp-3500	110	258	neurosurgery	neurosurgery	NOUN
fnp-3500	110	259	,	,	PUNCT
fnp-3500	110	260	mannheim	mannheim	PROPN
fnp-3500	110	261	,	,	PUNCT
fnp-3500	110	262	germany	germany	PROPN
fnp-3500	110	263	15	15	NUM
fnp-3500	110	264	german	german	ADJ
fnp-3500	110	265	cancer	cancer	NOUN
fnp-3500	110	266	research	research	NOUN
fnp-3500	110	267	center	center	NOUN
fnp-3500	110	268	(	(	PUNCT
fnp-3500	110	269	dkfz	dkfz	NOUN
fnp-3500	110	270	)	)	PUNCT
fnp-3500	110	271	,	,	PUNCT
fnp-3500	110	272	pediatric	pediatric	ADJ
fnp-3500	110	273	glioma	glioma	NOUN
fnp-3500	110	274	research	research	NOUN
fnp-3500	110	275	group	group	NOUN
fnp-3500	110	276	,	,	PUNCT
fnp-3500	110	277	heidelberg	heidelberg	PROPN
fnp-3500	110	278	,	,	PUNCT
fnp-3500	110	279	germany	germany	PROPN
fnp-3500	110	280	16	16	NUM
fnp-3500	110	281	university	university	PROPN
fnp-3500	110	282	hospital	hospital	PROPN
fnp-3500	110	283	heidelberg	heidelberg	PROPN
fnp-3500	110	284	,	,	PUNCT
fnp-3500	110	285	department	department	NOUN
fnp-3500	110	286	of	of	ADP
fnp-3500	110	287	pediatric	pediatric	ADJ
fnp-3500	110	288	oncology	oncology	NOUN
fnp-3500	110	289	and	and	CCONJ
fnp-3500	110	290	hematology	hematology	NOUN
fnp-3500	110	291	,	,	PUNCT
fnp-3500	110	292	heidelberg	heidelberg	PROPN
fnp-3500	110	293	,	,	PUNCT
fnp-3500	110	294	germany	germany	PROPN
fnp-3500	110	295	17	17	NUM
fnp-3500	110	296	university	university	PROPN
fnp-3500	110	297	hospital	hospital	PROPN
fnp-3500	110	298	heidelberg	heidelberg	PROPN
fnp-3500	110	299	,	,	PUNCT
fnp-3500	110	300	department	department	NOUN
fnp-3500	110	301	of	of	ADP
fnp-3500	110	302	neurosurgery	neurosurgery	NOUN
fnp-3500	110	303	,	,	PUNCT
fnp-3500	110	304	division	division	NOUN
fnp-3500	110	305	of	of	ADP
fnp-3500	110	306	experimental	experimental	ADJ
fnp-3500	110	307	neurosurgery	neurosurgery	NOUN
fnp-3500	110	308	,	,	PUNCT
fnp-3500	110	309	heidelberg	heidelberg	PROPN
fnp-3500	110	310	,	,	PUNCT
fnp-3500	110	311	germany	germany	PROPN
fnp-3500	110	312	18	18	NUM
fnp-3500	110	313	university	university	PROPN
fnp-3500	110	314	of	of	ADP
fnp-3500	110	315	heidelberg	heidelberg	PROPN
fnp-3500	110	316	medical	medical	ADJ
fnp-3500	110	317	center	center	NOUN
fnp-3500	110	318	,	,	PUNCT
fnp-3500	110	319	neurology	neurology	NOUN
fnp-3500	110	320	clinic	clinic	NOUN
fnp-3500	110	321	,	,	PUNCT
fnp-3500	110	322	heidelberg	heidelberg	PROPN
fnp-3500	110	323	,	,	PUNCT
fnp-3500	110	324	germany	germany	PROPN
fnp-3500	110	325	introduction	introduction	NOUN
fnp-3500	110	326	:	:	PUNCT
fnp-3500	110	327	diffuse	diffuse	VERB
fnp-3500	110	328	idh	idh	NOUN
fnp-3500	110	329	-	-	PUNCT
fnp-3500	110	330	mutant	mutant	NOUN
fnp-3500	110	331	astrocytic	astrocytic	ADJ
fnp-3500	110	332	tumors	tumor	NOUN
fnp-3500	110	333	are	be	AUX
fnp-3500	110	334	rarely	rarely	ADV
fnp-3500	110	335	diagnosed	diagnose	VERB
fnp-3500	110	336	in	in	ADP
fnp-3500	110	337	infratentorial	infratentorial	ADJ
fnp-3500	110	338	structures	structure	NOUN
fnp-3500	110	339	.	.	PUNCT
fnp-3500	111	1	only	only	ADV
fnp-3500	111	2	few	few	ADJ
fnp-3500	111	3	studies	study	NOUN
fnp-3500	111	4	have	have	AUX
fnp-3500	111	5	reported	report	VERB
fnp-3500	111	6	single	single	ADJ
fnp-3500	111	7	cases	case	NOUN
fnp-3500	111	8	of	of	ADP
fnp-3500	111	9	infratentorial	infratentorial	ADJ
fnp-3500	111	10	diffuse	diffuse	NOUN
fnp-3500	111	11	gliomas	glioma	NOUN
fnp-3500	111	12	harboring	harbor	VERB
fnp-3500	111	13	idh	idh	NOUN
fnp-3500	111	14	mutations	mutation	NOUN
fnp-3500	111	15	,	,	PUNCT
fnp-3500	111	16	while	while	SCONJ
fnp-3500	111	17	suffering	suffer	VERB
fnp-3500	111	18	small	small	ADJ
fnp-3500	111	19	case	case	NOUN
fnp-3500	111	20	numbers	number	NOUN
fnp-3500	111	21	.	.	PUNCT
fnp-3500	112	1	objectives	objective	NOUN
fnp-3500	112	2	:	:	PUNCT
fnp-3500	112	3	in	in	ADP
fnp-3500	112	4	this	this	DET
fnp-3500	112	5	multi	multi	ADJ
fnp-3500	112	6	-	-	ADJ
fnp-3500	112	7	institutional	institutional	ADJ
fnp-3500	112	8	study	study	NOUN
fnp-3500	112	9	,	,	PUNCT
fnp-3500	112	10	we	we	PRON
fnp-3500	112	11	aimed	aim	VERB
fnp-3500	112	12	to	to	PART
fnp-3500	112	13	analyze	analyze	VERB
fnp-3500	112	14	infratentorial	infratentorial	ADJ
fnp-3500	112	15	idh	idh	NOUN
fnp-3500	112	16	-	-	PUNCT
fnp-3500	112	17	mutant	mutant	NOUN
fnp-3500	112	18	astrocytomas	astrocytoma	NOUN
fnp-3500	112	19	in	in	ADP
fnp-3500	112	20	a	a	DET
fnp-3500	112	21	larger	large	ADJ
fnp-3500	112	22	series	series	NOUN
fnp-3500	112	23	with	with	ADP
fnp-3500	112	24	respect	respect	NOUN
fnp-3500	112	25	to	to	ADP
fnp-3500	112	26	clinical	clinical	ADJ
fnp-3500	112	27	and	and	CCONJ
fnp-3500	112	28	molecular	molecular	ADJ
fnp-3500	112	29	parameters	parameter	NOUN
fnp-3500	112	30	.	.	PUNCT
fnp-3500	113	1	patients	patient	NOUN
fnp-3500	113	2	and	and	CCONJ
fnp-3500	113	3	methods	method	NOUN
fnp-3500	113	4	:	:	PUNCT
fnp-3500	113	5	tumor	tumor	NOUN
fnp-3500	113	6	samples	sample	NOUN
fnp-3500	113	7	of	of	ADP
fnp-3500	113	8	patients	patient	NOUN
fnp-3500	113	9	with	with	ADP
fnp-3500	113	10	diffuse	diffuse	ADJ
fnp-3500	113	11	infratentorial	infratentorial	ADJ
fnp-3500	113	12	astrocytomas	astrocytoma	NOUN
fnp-3500	113	13	from	from	ADP
fnp-3500	113	14	different	different	ADJ
fnp-3500	113	15	german	german	ADJ
fnp-3500	113	16	neuropathology	neuropathology	NOUN
fnp-3500	113	17	departments	department	NOUN
fnp-3500	113	18	were	be	AUX
fnp-3500	113	19	investigated	investigate	VERB
fnp-3500	113	20	using	use	VERB
fnp-3500	113	21	immunohistochemistry	immunohistochemistry	NOUN
fnp-3500	113	22	,	,	PUNCT
fnp-3500	113	23	pyrosequencing	pyrosequencing	NOUN
fnp-3500	113	24	,	,	PUNCT
fnp-3500	113	25	genome	genome	NOUN
fnp-3500	113	26	-	-	PUNCT
fnp-3500	113	27	wide	wide	ADJ
fnp-3500	113	28	dna	dna	PROPN
fnp-3500	113	29	methylation	methylation	NOUN
fnp-3500	113	30	analysis	analysis	NOUN
fnp-3500	113	31	and	and	CCONJ
fnp-3500	113	32	ngs	ng	NOUN
fnp-3500	113	33	panel	panel	NOUN
fnp-3500	113	34	sequencing	sequence	VERB
fnp-3500	113	35	.	.	PUNCT
fnp-3500	114	1	overall	overall	ADJ
fnp-3500	114	2	survival	survival	NOUN
fnp-3500	114	3	data	datum	NOUN
fnp-3500	114	4	were	be	AUX
fnp-3500	114	5	assessed	assess	VERB
fnp-3500	114	6	using	use	VERB
fnp-3500	114	7	kaplan	kaplan	PROPN
fnp-3500	114	8	–	–	PUNCT
fnp-3500	114	9	meier	meier	PROPN
fnp-3500	114	10	method	method	PROPN
fnp-3500	114	11	.	.	PUNCT
fnp-3500	115	1	results	result	NOUN
fnp-3500	115	2	:	:	PUNCT
fnp-3500	115	3	we	we	PRON
fnp-3500	115	4	identified	identify	VERB
fnp-3500	115	5	a	a	DET
fnp-3500	115	6	series	series	NOUN
fnp-3500	115	7	of	of	ADP
fnp-3500	115	8	43	43	NUM
fnp-3500	115	9	infratentorial	infratentorial	ADJ
fnp-3500	115	10	idh	idh	NOUN
fnp-3500	115	11	-	-	PUNCT
fnp-3500	115	12	mutant	mutant	NOUN
fnp-3500	115	13	astrocytomas	astrocytoma	NOUN
fnp-3500	115	14	from	from	ADP
fnp-3500	115	15	42	42	NUM
fnp-3500	115	16	patients	patient	NOUN
fnp-3500	115	17	.	.	PUNCT
fnp-3500	116	1	about	about	ADV
fnp-3500	116	2	80	80	NUM
fnp-3500	116	3	%	%	NOUN
fnp-3500	116	4	of	of	ADP
fnp-3500	116	5	idh	idh	NOUN
fnp-3500	116	6	mutations	mutation	NOUN
fnp-3500	116	7	were	be	AUX
fnp-3500	116	8	of	of	ADP
fnp-3500	116	9	non	non	ADJ
fnp-3500	116	10	-	-	ADJ
fnp-3500	116	11	idh1	idh1	ADJ
fnp-3500	116	12	-	-	PUNCT
fnp-3500	116	13	r132h	r132h	PROPN
fnp-3500	116	14	variants	variant	NOUN
fnp-3500	116	15	which	which	PRON
fnp-3500	116	16	are	be	AUX
fnp-3500	116	17	rare	rare	ADJ
fnp-3500	116	18	in	in	ADP
fnp-3500	116	19	supratentorial	supratentorial	ADJ
fnp-3500	116	20	astrocytomas	astrocytoma	NOUN
fnp-3500	116	21	.	.	PUNCT
fnp-3500	117	1	most	most	ADV
fnp-3500	117	2	frequently	frequently	ADV
fnp-3500	117	3	,	,	PUNCT
fnp-3500	117	4	idh1	idh1	PROPN
fnp-3500	117	5	-	-	PUNCT
fnp-3500	117	6	r132c	r132c	PROPN
fnp-3500	117	7	/	/	SYM
fnp-3500	117	8	g	g	PROPN
fnp-3500	117	9	and	and	CCONJ
fnp-3500	117	10	idh2	idh2	PROPN
fnp-3500	117	11	-	-	PUNCT
fnp-3500	117	12	r172s	r172s	PROPN
fnp-3500	117	13	/	/	SYM
fnp-3500	117	14	g	g	NOUN
fnp-3500	117	15	mutations	mutation	NOUN
fnp-3500	117	16	were	be	AUX
fnp-3500	117	17	present	present	ADJ
fnp-3500	117	18	.	.	PUNCT
fnp-3500	118	1	moreover	moreover	ADV
fnp-3500	118	2	,	,	PUNCT
fnp-3500	118	3	atrx	atrx	ADJ
fnp-3500	118	4	-	-	PUNCT
fnp-3500	118	5	loss	loss	NOUN
fnp-3500	118	6	and	and	CCONJ
fnp-3500	118	7	mgmt	mgmt	NOUN
fnp-3500	118	8	promoter	promoter	NOUN
fnp-3500	118	9	methylation	methylation	NOUN
fnp-3500	118	10	typically	typically	ADV
fnp-3500	118	11	associated	associate	VERB
fnp-3500	118	12	with	with	ADP
fnp-3500	118	13	idh	idh	NOUN
fnp-3500	118	14	mutations	mutation	NOUN
fnp-3500	118	15	in	in	ADP
fnp-3500	118	16	supratentorial	supratentorial	ADJ
fnp-3500	118	17	astrocytomas	astrocytoma	NOUN
fnp-3500	118	18	,	,	PUNCT
fnp-3500	118	19	were	be	AUX
fnp-3500	118	20	significantly	significantly	ADV
fnp-3500	118	21	less	less	ADV
fnp-3500	118	22	frequent	frequent	ADJ
fnp-3500	118	23	in	in	ADP
fnp-3500	118	24	the	the	DET
fnp-3500	118	25	infratentorial	infratentorial	ADJ
fnp-3500	118	26	compartment	compartment	NOUN
fnp-3500	118	27	.	.	PUNCT
fnp-3500	119	1	panel	panel	NOUN
fnp-3500	119	2	sequencing	sequence	VERB
fnp-3500	119	3	revealed	reveal	VERB
fnp-3500	119	4	two	two	NUM
fnp-3500	119	5	samples	sample	NOUN
fnp-3500	119	6	with	with	ADP
fnp-3500	119	7	idh1	idh1	PROPN
fnp-3500	119	8	-	-	PUNCT
fnp-3500	119	9	r132c	r132c	PROPN
fnp-3500	119	10	/	/	SYM
fnp-3500	119	11	h3f3a	h3f3a	NOUN
fnp-3500	119	12	-	-	PUNCT
fnp-3500	119	13	k27	k27	NOUN
fnp-3500	119	14	m	m	NOUN
fnp-3500	119	15	co	co	NOUN
fnp-3500	119	16	-	-	NOUN
fnp-3500	119	17	mutations	mutation	NOUN
fnp-3500	119	18	.	.	PUNCT
fnp-3500	120	1	methylation	methylation	NOUN
fnp-3500	120	2	analysis	analysis	NOUN
fnp-3500	120	3	and	and	CCONJ
fnp-3500	120	4	copy	copy	VERB
fnp-3500	120	5	number	number	NOUN
fnp-3500	120	6	profiling	profiling	NOUN
fnp-3500	120	7	provided	provide	VERB
fnp-3500	120	8	further	further	ADJ
fnp-3500	120	9	evidence	evidence	NOUN
fnp-3500	120	10	for	for	ADP
fnp-3500	120	11	a	a	DET
fnp-3500	120	12	molecular	molecular	ADJ
fnp-3500	120	13	distinctiveness	distinctiveness	NOUN
fnp-3500	120	14	of	of	ADP
fnp-3500	120	15	these	these	DET
fnp-3500	120	16	tumors	tumor	NOUN
fnp-3500	120	17	.	.	PUNCT
fnp-3500	121	1	clinical	clinical	ADJ
fnp-3500	121	2	outcome	outcome	NOUN
fnp-3500	121	3	of	of	ADP
fnp-3500	121	4	patients	patient	NOUN
fnp-3500	121	5	with	with	ADP
fnp-3500	121	6	infratentorial	infratentorial	ADJ
fnp-3500	121	7	idh	idh	NOUN
fnp-3500	121	8	-	-	PUNCT
fnp-3500	121	9	mutant	mutant	NOUN
fnp-3500	121	10	astrocytomas	astrocytoma	NOUN
fnp-3500	121	11	was	be	AUX
fnp-3500	121	12	significantly	significantly	ADV
fnp-3500	121	13	better	well	ADJ
fnp-3500	121	14	than	than	ADP
fnp-3500	121	15	in	in	ADP
fnp-3500	121	16	patients	patient	NOUN
fnp-3500	121	17	with	with	ADP
fnp-3500	121	18	diffuse	diffuse	ADJ
fnp-3500	121	19	midline	midline	NOUN
fnp-3500	121	20	gliomas	glioma	NOUN
fnp-3500	121	21	,	,	PUNCT
fnp-3500	121	22	h3k27m	h3k27m	NOUN
fnp-3500	121	23	-	-	ADJ
fnp-3500	121	24	mutant	mutant	NOUN
fnp-3500	121	25	(	(	PUNCT
fnp-3500	121	26	p	p	X
fnp-3500	121	27	<	<	X
fnp-3500	121	28	0.005	0.005	NUM
fnp-3500	121	29	)	)	PUNCT
fnp-3500	121	30	and	and	CCONJ
fnp-3500	121	31	poorer	poor	ADJ
fnp-3500	121	32	than	than	ADP
fnp-3500	121	33	in	in	ADP
fnp-3500	121	34	those	those	PRON
fnp-3500	121	35	with	with	ADP
fnp-3500	121	36	supratentorial	supratentorial	ADJ
fnp-3500	121	37	idh	idh	NOUN
fnp-3500	121	38	-	-	PUNCT
fnp-3500	121	39	mutant	mutant	NOUN
fnp-3500	121	40	astrocytomas	astrocytoma	NOUN
fnp-3500	121	41	(	(	PUNCT
fnp-3500	121	42	p	p	X
fnp-3500	121	43	=	=	NOUN
fnp-3500	121	44	0.028	0.028	NUM
fnp-3500	121	45	)	)	PUNCT
fnp-3500	121	46	.	.	PUNCT
fnp-3500	122	1	conclusion	conclusion	NOUN
fnp-3500	122	2	:	:	PUNCT
fnp-3500	122	3	the	the	DET
fnp-3500	122	4	presented	present	VERB
fnp-3500	122	5	data	datum	NOUN
fnp-3500	122	6	highlight	highlight	VERB
fnp-3500	122	7	the	the	DET
fnp-3500	122	8	very	very	ADJ
fnp-3500	122	9	existence	existence	NOUN
fnp-3500	122	10	and	and	CCONJ
fnp-3500	122	11	distinctiveness	distinctiveness	NOUN
fnp-3500	122	12	of	of	ADP
fnp-3500	122	13	infratentorial	infratentorial	ADJ
fnp-3500	122	14	idh	idh	NOUN
fnp-3500	122	15	-	-	PUNCT
fnp-3500	122	16	mutant	mutant	NOUN
fnp-3500	122	17	astrocytomas	astrocytoma	NOUN
fnp-3500	122	18	implying	imply	VERB
fnp-3500	122	19	that	that	SCONJ
fnp-3500	122	20	molecular	molecular	ADJ
fnp-3500	122	21	testing	testing	NOUN
fnp-3500	122	22	is	be	AUX
fnp-3500	122	23	critical	critical	ADJ
fnp-3500	122	24	for	for	ADP
fnp-3500	122	25	detection	detection	NOUN
fnp-3500	122	26	of	of	ADP
fnp-3500	122	27	these	these	DET
fnp-3500	122	28	tumors	tumor	NOUN
fnp-3500	122	29	,	,	PUNCT
fnp-3500	122	30	since	since	SCONJ
fnp-3500	122	31	many	many	ADJ
fnp-3500	122	32	of	of	ADP
fnp-3500	122	33	these	these	DET
fnp-3500	122	34	tumors	tumor	NOUN
fnp-3500	122	35	can	can	AUX
fnp-3500	122	36	not	not	PART
fnp-3500	122	37	be	be	AUX
fnp-3500	122	38	identified	identify	VERB
fnp-3500	122	39	by	by	ADP
fnp-3500	122	40	immunohistochemistry	immunohistochemistry	NOUN
fnp-3500	122	41	applied	apply	VERB
fnp-3500	122	42	for	for	ADP
fnp-3500	122	43	the	the	DET
fnp-3500	122	44	mutated	mutate	VERB
fnp-3500	122	45	idh1	idh1	PROPN
fnp-3500	122	46	-	-	PUNCT
fnp-3500	122	47	r132h	r132h	PROPN
fnp-3500	122	48	protein	protein	NOUN
fnp-3500	122	49	or	or	CCONJ
fnp-3500	122	50	loss	loss	NOUN
fnp-3500	122	51	of	of	ADP
fnp-3500	122	52	atrx	atrx	NOUN
fnp-3500	122	53	.	.	PUNCT
fnp-3500	122	54	  	  	SPACE
fnp-3500	122	55	noa-06	noa-06	ADP
fnp-3500	122	56	free	free	ADJ
fnp-3500	122	57	neuropathol	neuropathol	NOUN
fnp-3500	122	58	2:22:16	2:22:16	NUM
fnp-3500	122	59	dna	dna	PROPN
fnp-3500	122	60	methylation	methylation	NOUN
fnp-3500	122	61	profiling	profiling	NOUN
fnp-3500	122	62	and	and	CCONJ
fnp-3500	122	63	molecular	molecular	ADJ
fnp-3500	122	64	grading	grading	NOUN
fnp-3500	122	65	of	of	ADP
fnp-3500	122	66	stereotaxic	stereotaxic	ADJ
fnp-3500	122	67	brain	brain	NOUN
fnp-3500	122	68	tumor	tumor	NOUN
fnp-3500	122	69	biopsies	biopsy	NOUN
fnp-3500	122	70	k.	k.	PROPN
fnp-3500	122	71	filipski1,2,3	filipski1,2,3	PROPN
fnp-3500	122	72	,	,	PUNCT
fnp-3500	122	73	j.	j.	PROPN
fnp-3500	122	74	hench4	hench4	PROPN
fnp-3500	122	75	,	,	PUNCT
fnp-3500	122	76	m.	m.	NOUN
fnp-3500	122	77	armbrust1	armbrust1	PROPN
fnp-3500	122	78	,	,	PUNCT
fnp-3500	122	79	p.	p.	PROPN
fnp-3500	122	80	s.	s.	PROPN
fnp-3500	122	81	zeiner2,3,5	zeiner2,3,5	PROPN
fnp-3500	122	82	,	,	PUNCT
fnp-3500	122	83	t.	t.	PROPN
fnp-3500	122	84	i.	i.	PROPN
fnp-3500	122	85	hartung1	hartung1	PROPN
fnp-3500	122	86	,	,	PUNCT
fnp-3500	122	87	e.	e.	PROPN
fnp-3500	122	88	steidl6	steidl6	PROPN
fnp-3500	122	89	,	,	PUNCT
fnp-3500	122	90	j.	j.	PROPN
fnp-3500	122	91	quick	quick	ADJ
fnp-3500	122	92	-	-	PUNCT
fnp-3500	122	93	weller7	weller7	NOUN
fnp-3500	122	94	,	,	PUNCT
fnp-3500	122	95	t.	t.	PROPN
fnp-3500	122	96	fenton8	fenton8	PROPN
fnp-3500	122	97	,	,	PUNCT
fnp-3500	122	98	j.	j.	PROPN
fnp-3500	122	99	p.	p.	PROPN
fnp-3500	122	100	steinbach2,3,5	steinbach2,3,5	PROPN
fnp-3500	122	101	,	,	PUNCT
fnp-3500	122	102	m.	m.	PROPN
fnp-3500	122	103	czabanka7	czabanka7	PROPN
fnp-3500	122	104	,	,	PUNCT
fnp-3500	122	105	d.	d.	PROPN
fnp-3500	122	106	capper9,10	capper9,10	PROPN
fnp-3500	122	107	,	,	PUNCT
fnp-3500	122	108	s.	s.	PROPN
fnp-3500	122	109	frank4	frank4	PROPN
fnp-3500	122	110	,	,	PUNCT
fnp-3500	122	111	k.	k.	PROPN
fnp-3500	122	112	h.	h.	PROPN
fnp-3500	122	113	plate1,2,3	plate1,2,3	PROPN
fnp-3500	122	114	,	,	PUNCT
fnp-3500	122	115	m.	m.	NOUN
fnp-3500	122	116	t.	t.	PROPN
fnp-3500	122	117	forster7	forster7	PROPN
fnp-3500	122	118	,	,	PUNCT
fnp-3500	122	119	p.	p.	PROPN
fnp-3500	122	120	n.	n.	PROPN
fnp-3500	123	1	harter1,2,3	harter1,2,3	PROPN
fnp-3500	123	2	1	1	NUM
fnp-3500	123	3	university	university	NOUN
fnp-3500	123	4	hospital	hospital	NOUN
fnp-3500	123	5	frankfurt	frankfurt	PROPN
fnp-3500	123	6	,	,	PUNCT
fnp-3500	123	7	neurological	neurological	ADJ
fnp-3500	123	8	institute	institute	NOUN
fnp-3500	123	9	(	(	PUNCT
fnp-3500	123	10	edinger	edinger	PROPN
fnp-3500	123	11	institute	institute	PROPN
fnp-3500	123	12	)	)	PUNCT
fnp-3500	123	13	,	,	PUNCT
fnp-3500	123	14	frankfurt	frankfurt	PROPN
fnp-3500	123	15	a.	a.	NOUN
fnp-3500	123	16	m.	m.	PROPN
fnp-3500	123	17	,	,	PUNCT
fnp-3500	123	18	germany	germany	PROPN
fnp-3500	123	19	2	2	NUM
fnp-3500	123	20	german	german	ADJ
fnp-3500	123	21	cancer	cancer	NOUN
fnp-3500	123	22	consortium	consortium	NOUN
fnp-3500	123	23	(	(	PUNCT
fnp-3500	123	24	dktk	dktk	NOUN
fnp-3500	123	25	)	)	PUNCT
fnp-3500	123	26	,	,	PUNCT
fnp-3500	123	27	german	german	ADJ
fnp-3500	123	28	cancer	cancer	NOUN
fnp-3500	123	29	research	research	NOUN
fnp-3500	123	30	center	center	NOUN
fnp-3500	123	31	(	(	PUNCT
fnp-3500	123	32	dkfz	dkfz	PROPN
fnp-3500	123	33	)	)	PUNCT
fnp-3500	123	34	,	,	PUNCT
fnp-3500	123	35	heidelberg	heidelberg	PROPN
fnp-3500	123	36	,	,	PUNCT
fnp-3500	123	37	germany	germany	PROPN
fnp-3500	123	38	3	3	NUM
fnp-3500	123	39	frankfurt	frankfurt	PROPN
fnp-3500	123	40	cancer	cancer	PROPN
fnp-3500	123	41	institute	institute	PROPN
fnp-3500	123	42	(	(	PUNCT
fnp-3500	123	43	fci	fci	PROPN
fnp-3500	123	44	)	)	PUNCT
fnp-3500	123	45	,	,	PUNCT
fnp-3500	123	46	frankfurt	frankfurt	PROPN
fnp-3500	123	47	a.	a.	NOUN
fnp-3500	123	48	m.	m.	PROPN
fnp-3500	123	49	,	,	PUNCT
fnp-3500	123	50	germany	germany	PROPN
fnp-3500	123	51	4	4	NUM
fnp-3500	123	52	basel	basel	PROPN
fnp-3500	123	53	university	university	PROPN
fnp-3500	123	54	hospital	hospital	NOUN
fnp-3500	123	55	,	,	PUNCT
fnp-3500	123	56	department	department	NOUN
fnp-3500	123	57	of	of	ADP
fnp-3500	123	58	neuropathology	neuropathology	NOUN
fnp-3500	123	59	,	,	PUNCT
fnp-3500	123	60	institute	institute	PROPN
fnp-3500	123	61	of	of	ADP
fnp-3500	123	62	pathology	pathology	PROPN
fnp-3500	123	63	,	,	PUNCT
fnp-3500	123	64	basel	basel	PROPN
fnp-3500	123	65	,	,	PUNCT
fnp-3500	123	66	switzerland	switzerland	PROPN
fnp-3500	123	67	5	5	NUM
fnp-3500	123	68	university	university	NOUN
fnp-3500	123	69	hospital	hospital	NOUN
fnp-3500	123	70	frankfurt	frankfurt	PROPN
fnp-3500	123	71	,	,	PUNCT
fnp-3500	123	72	dr	dr	PROPN
fnp-3500	123	73	.	.	PROPN
fnp-3500	123	74	senckenberg	senckenberg	PROPN
fnp-3500	123	75	institute	institute	PROPN
fnp-3500	123	76	of	of	ADP
fnp-3500	123	77	neurooncology	neurooncology	PROPN
fnp-3500	123	78	,	,	PUNCT
fnp-3500	123	79	frankfurt	frankfurt	PROPN
fnp-3500	123	80	a.	a.	NOUN
fnp-3500	123	81	m.	m.	PROPN
fnp-3500	123	82	,	,	PUNCT
fnp-3500	123	83	germany	germany	PROPN
fnp-3500	123	84	6	6	NUM
fnp-3500	123	85	university	university	NOUN
fnp-3500	123	86	hospital	hospital	NOUN
fnp-3500	123	87	frankfurt	frankfurt	PROPN
fnp-3500	123	88	,	,	PUNCT
fnp-3500	123	89	institute	institute	PROPN
fnp-3500	123	90	of	of	ADP
fnp-3500	123	91	neuroradiology	neuroradiology	PROPN
fnp-3500	123	92	,	,	PUNCT
fnp-3500	123	93	frankfurt	frankfurt	PROPN
fnp-3500	123	94	a.	a.	NOUN
fnp-3500	123	95	m.	m.	PROPN
fnp-3500	123	96	,	,	PUNCT
fnp-3500	123	97	germany	germany	PROPN
fnp-3500	123	98	7	7	NUM
fnp-3500	123	99	university	university	PROPN
fnp-3500	123	100	hospital	hospital	NOUN
fnp-3500	123	101	frankfurt	frankfurt	PROPN
fnp-3500	123	102	,	,	PUNCT
fnp-3500	123	103	department	department	NOUN
fnp-3500	123	104	of	of	ADP
fnp-3500	123	105	neurosurgery	neurosurgery	NOUN
fnp-3500	123	106	,	,	PUNCT
fnp-3500	123	107	frankfurt	frankfurt	PROPN
fnp-3500	123	108	a.	a.	NOUN
fnp-3500	123	109	m.	m.	PROPN
fnp-3500	123	110	,	,	PUNCT
fnp-3500	123	111	germany	germany	PROPN
fnp-3500	123	112	8	8	NUM
fnp-3500	123	113	university	university	PROPN
fnp-3500	123	114	of	of	ADP
fnp-3500	123	115	kent	kent	PROPN
fnp-3500	123	116	,	,	PUNCT
fnp-3500	123	117	school	school	NOUN
fnp-3500	123	118	of	of	ADP
fnp-3500	123	119	bioscience	bioscience	NOUN
fnp-3500	123	120	,	,	PUNCT
fnp-3500	123	121	kent	kent	PROPN
fnp-3500	123	122	,	,	PUNCT
fnp-3500	123	123	united	united	ADJ
fnp-3500	123	124	kingdom	kingdom	PROPN
fnp-3500	123	125	9	9	NUM
fnp-3500	123	126	charité	charité	PROPN
fnp-3500	123	127	–	–	PUNCT
fnp-3500	123	128	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	123	129	berlin	berlin	PROPN
fnp-3500	123	130	,	,	PUNCT
fnp-3500	123	131	department	department	NOUN
fnp-3500	123	132	of	of	ADP
fnp-3500	123	133	neuropathology	neuropathology	NOUN
fnp-3500	123	134	,	,	PUNCT
fnp-3500	123	135	berlin	berlin	PROPN
fnp-3500	123	136	,	,	PUNCT
fnp-3500	123	137	germany	germany	PROPN
fnp-3500	123	138	10	10	NUM
fnp-3500	123	139	german	german	ADJ
fnp-3500	123	140	cancer	cancer	NOUN
fnp-3500	123	141	consortium	consortium	NOUN
fnp-3500	123	142	(	(	PUNCT
fnp-3500	123	143	dktk	dktk	NOUN
fnp-3500	123	144	)	)	PUNCT
fnp-3500	123	145	,	,	PUNCT
fnp-3500	123	146	partner	partner	NOUN
fnp-3500	123	147	site	site	NOUN
fnp-3500	123	148	berlin	berlin	PROPN
fnp-3500	123	149	,	,	PUNCT
fnp-3500	123	150	german	german	ADJ
fnp-3500	123	151	cancer	cancer	NOUN
fnp-3500	123	152	research	research	NOUN
fnp-3500	123	153	center	center	NOUN
fnp-3500	123	154	(	(	PUNCT
fnp-3500	123	155	dkfz	dkfz	PROPN
fnp-3500	123	156	)	)	PUNCT
fnp-3500	123	157	,	,	PUNCT
fnp-3500	123	158	heidelberg	heidelberg	PROPN
fnp-3500	123	159	,	,	PUNCT
fnp-3500	123	160	germany	germany	PROPN
fnp-3500	123	161	introduction	introduction	NOUN
fnp-3500	123	162	:	:	PUNCT
fnp-3500	123	163	dna	dna	PROPN
fnp-3500	123	164	methylation	methylation	NOUN
fnp-3500	123	165	profiling	profiling	NOUN
fnp-3500	123	166	of	of	ADP
fnp-3500	123	167	cns	cns	PROPN
fnp-3500	123	168	tumors	tumor	NOUN
fnp-3500	123	169	emerges	emerge	VERB
fnp-3500	123	170	as	as	ADP
fnp-3500	123	171	a	a	DET
fnp-3500	123	172	powerful	powerful	ADJ
fnp-3500	123	173	tool	tool	NOUN
fnp-3500	123	174	to	to	PART
fnp-3500	123	175	support	support	VERB
fnp-3500	123	176	and	and	CCONJ
fnp-3500	123	177	refine	refine	VERB
fnp-3500	123	178	histological	histological	ADJ
fnp-3500	123	179	diagnoses	diagnosis	NOUN
fnp-3500	123	180	.	.	PUNCT
fnp-3500	124	1	tumor	tumor	NOUN
fnp-3500	124	2	entity	entity	NOUN
fnp-3500	124	3	-	-	PUNCT
fnp-3500	124	4	specific	specific	ADJ
fnp-3500	124	5	dna	dna	PROPN
fnp-3500	124	6	methylation	methylation	NOUN
fnp-3500	124	7	signatures	signature	NOUN
fnp-3500	124	8	allow	allow	VERB
fnp-3500	124	9	for	for	ADP
fnp-3500	124	10	alignment	alignment	NOUN
fnp-3500	124	11	with	with	ADP
fnp-3500	124	12	methylation	methylation	NOUN
fnp-3500	124	13	classes	class	NOUN
fnp-3500	124	14	and	and	CCONJ
fnp-3500	124	15	copy	copy	VERB
fnp-3500	124	16	number	number	NOUN
fnp-3500	124	17	profiling	profiling	NOUN
fnp-3500	124	18	(	(	PUNCT
fnp-3500	124	19	cnp	cnp	PROPN
fnp-3500	124	20	)	)	PUNCT
fnp-3500	124	21	,	,	PUNCT
fnp-3500	124	22	the	the	DET
fnp-3500	124	23	latter	latter	ADJ
fnp-3500	124	24	being	being	NOUN
fnp-3500	124	25	of	of	ADP
fnp-3500	124	26	particular	particular	ADJ
fnp-3500	124	27	interest	interest	NOUN
fnp-3500	124	28	in	in	ADP
fnp-3500	124	29	terms	term	NOUN
fnp-3500	124	30	of	of	ADP
fnp-3500	124	31	molecular	molecular	ADJ
fnp-3500	124	32	grading	grading	NOUN
fnp-3500	124	33	regarding	regard	VERB
fnp-3500	124	34	the	the	DET
fnp-3500	124	35	upcoming	upcoming	NOUN
fnp-3500	124	36	who	who	PRON
fnp-3500	124	37	classification	classification	VERB
fnp-3500	124	38	.	.	PUNCT
fnp-3500	125	1	when	when	SCONJ
fnp-3500	125	2	gross	gross	ADJ
fnp-3500	125	3	tumor	tumor	NOUN
fnp-3500	125	4	resection	resection	NOUN
fnp-3500	125	5	is	be	AUX
fnp-3500	125	6	precluded	preclude	VERB
fnp-3500	125	7	,	,	PUNCT
fnp-3500	125	8	stereotaxic	stereotaxic	ADJ
fnp-3500	125	9	biopsies	biopsy	NOUN
fnp-3500	125	10	might	might	AUX
fnp-3500	125	11	not	not	PART
fnp-3500	125	12	be	be	AUX
fnp-3500	125	13	representative	representative	ADJ
fnp-3500	125	14	of	of	ADP
fnp-3500	125	15	the	the	DET
fnp-3500	125	16	bulk	bulk	ADJ
fnp-3500	125	17	tumor	tumor	NOUN
fnp-3500	125	18	,	,	PUNCT
fnp-3500	125	19	underlining	underline	VERB
fnp-3500	125	20	the	the	DET
fnp-3500	125	21	need	need	NOUN
fnp-3500	125	22	for	for	ADP
fnp-3500	125	23	objective	objective	ADJ
fnp-3500	125	24	molecular	molecular	ADJ
fnp-3500	125	25	diagnostic	diagnostic	ADJ
fnp-3500	125	26	parameters	parameter	NOUN
fnp-3500	125	27	.	.	PUNCT
fnp-3500	126	1	objective	objective	NOUN
fnp-3500	126	2	:	:	PUNCT
fnp-3500	126	3	here	here	ADV
fnp-3500	126	4	we	we	PRON
fnp-3500	126	5	investigated	investigate	VERB
fnp-3500	126	6	the	the	DET
fnp-3500	126	7	diagnostic	diagnostic	ADJ
fnp-3500	126	8	potential	potential	NOUN
fnp-3500	126	9	and	and	CCONJ
fnp-3500	126	10	accuracy	accuracy	NOUN
fnp-3500	126	11	of	of	ADP
fnp-3500	126	12	dna	dna	PROPN
fnp-3500	126	13	methylation	methylation	NOUN
fnp-3500	126	14	profiling	profiling	NOUN
fnp-3500	126	15	and	and	CCONJ
fnp-3500	126	16	molecular	molecular	ADJ
fnp-3500	126	17	grading	grade	VERB
fnp-3500	126	18	on	on	ADP
fnp-3500	126	19	small	small	ADJ
fnp-3500	126	20	stereotaxic	stereotaxic	ADJ
fnp-3500	126	21	brain	brain	NOUN
fnp-3500	126	22	tumor	tumor	NOUN
fnp-3500	126	23	biopsies	biopsy	NOUN
fnp-3500	126	24	.	.	PUNCT
fnp-3500	127	1	materials	material	NOUN
fnp-3500	127	2	&	&	CCONJ
fnp-3500	127	3	methods	method	NOUN
fnp-3500	127	4	:	:	PUNCT
fnp-3500	127	5	ffpe	ffpe	NOUN
fnp-3500	127	6	samples	sample	NOUN
fnp-3500	127	7	of	of	ADP
fnp-3500	127	8	237	237	NUM
fnp-3500	127	9	patients	patient	NOUN
fnp-3500	127	10	were	be	AUX
fnp-3500	127	11	subjected	subject	VERB
fnp-3500	127	12	to	to	ADP
fnp-3500	127	13	dna	dna	PROPN
fnp-3500	127	14	methylation	methylation	NOUN
fnp-3500	127	15	analysis	analysis	NOUN
fnp-3500	127	16	including	include	VERB
fnp-3500	127	17	the	the	DET
fnp-3500	127	18	heidelberg	heidelberg	NOUN
fnp-3500	127	19	brain	brain	NOUN
fnp-3500	127	20	tumor	tumor	PROPN
fnp-3500	127	21	classifier	classifier	NOUN
fnp-3500	127	22	,	,	PUNCT
fnp-3500	127	23	cnp	cnp	PROPN
fnp-3500	127	24	and	and	CCONJ
fnp-3500	127	25	tumor	tumor	NOUN
fnp-3500	127	26	deconvolution	deconvolution	NOUN
fnp-3500	127	27	using	use	VERB
fnp-3500	127	28	methylcibersort	methylcibersort	NOUN
fnp-3500	127	29	.	.	PUNCT
fnp-3500	128	1	results	result	NOUN
fnp-3500	128	2	:	:	PUNCT
fnp-3500	129	1	median	median	ADJ
fnp-3500	129	2	dna	dna	PROPN
fnp-3500	129	3	concentration	concentration	NOUN
fnp-3500	129	4	was	be	AUX
fnp-3500	129	5	6.26	6.26	NUM
fnp-3500	129	6	ng/µl	ng/µl	NUM
fnp-3500	129	7	.	.	PUNCT
fnp-3500	130	1	90.5	90.5	NUM
fnp-3500	130	2	%	%	NOUN
fnp-3500	130	3	of	of	ADP
fnp-3500	130	4	stx	stx	NOUN
fnp-3500	130	5	samples	sample	NOUN
fnp-3500	130	6	(	(	PUNCT
fnp-3500	130	7	n=232	n=232	NOUN
fnp-3500	130	8	)	)	PUNCT
fnp-3500	130	9	allocated	allocate	VERB
fnp-3500	130	10	to	to	ADP
fnp-3500	130	11	previously	previously	ADV
fnp-3500	130	12	defined	define	VERB
fnp-3500	130	13	dna	dna	PROPN
fnp-3500	130	14	methylation	methylation	NOUN
fnp-3500	130	15	classes	class	NOUN
fnp-3500	130	16	,	,	PUNCT
fnp-3500	130	17	with	with	ADP
fnp-3500	130	18	61.6	61.6	NUM
fnp-3500	130	19	%	%	NOUN
fnp-3500	130	20	reaching	reach	VERB
fnp-3500	130	21	classifier	classifier	NOUN
fnp-3500	130	22	scores	score	NOUN
fnp-3500	130	23	of	of	ADP
fnp-3500	130	24	>	>	DET
fnp-3500	130	25	0.84	0.84	NUM
fnp-3500	130	26	.	.	PUNCT
fnp-3500	131	1	combined	combine	VERB
fnp-3500	131	2	gain	gain	NOUN
fnp-3500	131	3	of	of	ADP
fnp-3500	131	4	chromosome	chromosome	NOUN
fnp-3500	131	5	7	7	NUM
fnp-3500	131	6	and	and	CCONJ
fnp-3500	131	7	loss	loss	NOUN
fnp-3500	131	8	of	of	ADP
fnp-3500	131	9	chromosome	chromosome	NOUN
fnp-3500	131	10	10	10	NUM
fnp-3500	131	11	or	or	CCONJ
fnp-3500	131	12	egfr	egfr	ADJ
fnp-3500	131	13	amplification	amplification	NOUN
fnp-3500	131	14	were	be	AUX
fnp-3500	131	15	detectable	detectable	ADJ
fnp-3500	131	16	in	in	ADP
fnp-3500	131	17	61	61	NUM
fnp-3500	131	18	%	%	NOUN
fnp-3500	131	19	and	and	CCONJ
fnp-3500	131	20	38	38	NUM
fnp-3500	131	21	%	%	NOUN
fnp-3500	131	22	of	of	ADP
fnp-3500	131	23	idh	idh	PROPN
fnp-3500	131	24	wildtype	wildtype	NOUN
fnp-3500	131	25	glioma	glioma	NOUN
fnp-3500	131	26	(	(	PUNCT
fnp-3500	131	27	n=156	n=156	PROPN
fnp-3500	131	28	)	)	PUNCT
fnp-3500	131	29	,	,	PUNCT
fnp-3500	131	30	respectively	respectively	ADV
fnp-3500	131	31	.	.	PUNCT
fnp-3500	132	1	64.5	64.5	NUM
fnp-3500	132	2	%	%	NOUN
fnp-3500	132	3	of	of	ADP
fnp-3500	132	4	histological	histological	ADJ
fnp-3500	132	5	lower	low	ADJ
fnp-3500	132	6	grade	grade	NOUN
fnp-3500	132	7	,	,	PUNCT
fnp-3500	132	8	idh	idh	NOUN
fnp-3500	132	9	wildtype	wildtype	NOUN
fnp-3500	132	10	gliomas	glioma	NOUN
fnp-3500	132	11	(	(	PUNCT
fnp-3500	132	12	n=31	n=31	NOUN
fnp-3500	132	13	)	)	PUNCT
fnp-3500	132	14	were	be	AUX
fnp-3500	132	15	eligible	eligible	ADJ
fnp-3500	132	16	for	for	ADP
fnp-3500	132	17	upgrading	upgrade	VERB
fnp-3500	132	18	to	to	ADP
fnp-3500	132	19	molecular	molecular	ADJ
fnp-3500	132	20	glioblastoma	glioblastoma	NOUN
fnp-3500	132	21	.	.	PUNCT
fnp-3500	133	1	58	58	NUM
fnp-3500	133	2	%	%	NOUN
fnp-3500	133	3	of	of	ADP
fnp-3500	133	4	idh	idh	NOUN
fnp-3500	133	5	mutant	mutant	ADJ
fnp-3500	133	6	gliomas	glioma	NOUN
fnp-3500	133	7	(	(	PUNCT
fnp-3500	133	8	n=31	n=31	NOUN
fnp-3500	133	9	)	)	PUNCT
fnp-3500	133	10	presented	present	VERB
fnp-3500	133	11	with	with	ADP
fnp-3500	133	12	1p/19q	1p/19q	PROPN
fnp-3500	133	13	codeletion	codeletion	NOUN
fnp-3500	133	14	and	and	CCONJ
fnp-3500	133	15	23	23	NUM
fnp-3500	133	16	%	%	NOUN
fnp-3500	133	17	with	with	ADP
fnp-3500	133	18	homozygous	homozygous	ADJ
fnp-3500	133	19	deletion	deletion	NOUN
fnp-3500	133	20	of	of	ADP
fnp-3500	133	21	cdkn2a	cdkn2a	PROPN
fnp-3500	133	22	/	/	SYM
fnp-3500	133	23	b.	b.	PROPN
fnp-3500	133	24	recursive	recursive	ADJ
fnp-3500	133	25	partitioning	partitioning	PROPN
fnp-3500	133	26	pointed	point	VERB
fnp-3500	133	27	at	at	ADP
fnp-3500	133	28	a	a	DET
fnp-3500	133	29	minimum	minimum	NOUN
fnp-3500	133	30	of	of	ADP
fnp-3500	133	31	29.42	29.42	NUM
fnp-3500	133	32	%	%	NOUN
fnp-3500	133	33	cancer	cancer	NOUN
fnp-3500	133	34	cells	cell	NOUN
fnp-3500	133	35	for	for	ADP
fnp-3500	133	36	a	a	DET
fnp-3500	133	37	0.83	0.83	NUM
fnp-3500	133	38	probability	probability	NOUN
fnp-3500	133	39	to	to	PART
fnp-3500	133	40	reach	reach	VERB
fnp-3500	133	41	a	a	DET
fnp-3500	133	42	matching	matching	NOUN
fnp-3500	133	43	calibrated	calibrate	VERB
fnp-3500	133	44	score	score	NOUN
fnp-3500	133	45	in	in	ADP
fnp-3500	133	46	glioblastoma	glioblastoma	NOUN
fnp-3500	133	47	,	,	PUNCT
fnp-3500	133	48	idh	idh	PROPN
fnp-3500	133	49	wildtype	wildtype	PROPN
fnp-3500	133	50	.	.	PUNCT
fnp-3500	134	1	a	a	DET
fnp-3500	134	2	dna	dna	PROPN
fnp-3500	134	3	input	input	NOUN
fnp-3500	134	4	threshold	threshold	NOUN
fnp-3500	134	5	of	of	ADP
fnp-3500	134	6	3.53	3.53	NUM
fnp-3500	134	7	ng/µl	ng/µl	NUM
fnp-3500	134	8	yielded	yielded	ADJ
fnp-3500	134	9	matching	match	VERB
fnp-3500	134	10	dna	dna	PROPN
fnp-3500	134	11	methylation	methylation	NOUN
fnp-3500	134	12	classes	class	NOUN
fnp-3500	134	13	with	with	ADP
fnp-3500	134	14	a	a	DET
fnp-3500	134	15	probability	probability	NOUN
fnp-3500	134	16	of	of	ADP
fnp-3500	134	17	0.69	0.69	NUM
fnp-3500	134	18	.	.	PUNCT
fnp-3500	135	1	conclusion	conclusion	NOUN
fnp-3500	135	2	:	:	PUNCT
fnp-3500	135	3	our	our	PRON
fnp-3500	135	4	findings	finding	NOUN
fnp-3500	135	5	demonstrate	demonstrate	VERB
fnp-3500	135	6	broad	broad	ADJ
fnp-3500	135	7	applicability	applicability	NOUN
fnp-3500	135	8	of	of	ADP
fnp-3500	135	9	dna	dna	PROPN
fnp-3500	135	10	methylation	methylation	NOUN
fnp-3500	135	11	profiling	profiling	NOUN
fnp-3500	135	12	and	and	CCONJ
fnp-3500	135	13	molecular	molecular	ADJ
fnp-3500	135	14	grading	grade	VERB
fnp-3500	135	15	to	to	ADP
fnp-3500	135	16	challengingly	challengingly	ADV
fnp-3500	135	17	small	small	ADJ
fnp-3500	135	18	,	,	PUNCT
fnp-3500	135	19	ill	ill	ADV
fnp-3500	135	20	-	-	PUNCT
fnp-3500	135	21	defined	define	VERB
fnp-3500	135	22	brain	brain	NOUN
fnp-3500	135	23	tumor	tumor	NOUN
fnp-3500	135	24	specimens	specimen	NOUN
fnp-3500	135	25	with	with	ADP
fnp-3500	135	26	a	a	DET
fnp-3500	135	27	special	special	ADJ
fnp-3500	135	28	impact	impact	NOUN
fnp-3500	135	29	on	on	ADP
fnp-3500	135	30	grading	grading	NOUN
fnp-3500	135	31	of	of	ADP
fnp-3500	135	32	histologically	histologically	ADV
fnp-3500	135	33	lower	low	ADJ
fnp-3500	135	34	grade	grade	NOUN
fnp-3500	135	35	,	,	PUNCT
fnp-3500	135	36	non	non	ADJ
fnp-3500	135	37	-	-	ADJ
fnp-3500	135	38	idh	idh	ADJ
fnp-3500	135	39	mutant	mutant	NOUN
fnp-3500	135	40	diffuse	diffuse	NOUN
fnp-3500	135	41	gliomas	glioma	NOUN
fnp-3500	135	42	.	.	PUNCT
fnp-3500	135	43	  	  	SPACE
fnp-3500	135	44	noa-07	noa-07	NUM
fnp-3500	135	45	free	free	ADJ
fnp-3500	135	46	neuropathol	neuropathol	NOUN
fnp-3500	135	47	2:22:18	2:22:18	NUM
fnp-3500	135	48	prediction	prediction	NOUN
fnp-3500	135	49	of	of	ADP
fnp-3500	135	50	meningioma	meningioma	ADJ
fnp-3500	135	51	methylation	methylation	NOUN
fnp-3500	135	52	classes	class	NOUN
fnp-3500	135	53	using	use	VERB
fnp-3500	135	54	ai	ai	NOUN
fnp-3500	135	55	-	-	PUNCT
fnp-3500	135	56	assisted	assist	VERB
fnp-3500	135	57	digital	digital	ADJ
fnp-3500	135	58	histopathology	histopathology	NOUN
fnp-3500	135	59	j.	j.	PROPN
fnp-3500	135	60	sehring1	sehring1	PROPN
fnp-3500	135	61	,	,	PUNCT
fnp-3500	135	62	h.	h.	PROPN
fnp-3500	135	63	dohmen1	dohmen1	PROPN
fnp-3500	135	64	,	,	PUNCT
fnp-3500	135	65	m.	m.	PROPN
fnp-3500	135	66	manke1	manke1	PROPN
fnp-3500	135	67	,	,	PUNCT
fnp-3500	135	68	d.	d.	PROPN
fnp-3500	135	69	amsel1	amsel1	PROPN
fnp-3500	135	70	,	,	PUNCT
fnp-3500	135	71	a.	a.	PROPN
fnp-3500	135	72	németh1	németh1	PROPN
fnp-3500	135	73	,	,	PUNCT
fnp-3500	135	74	a.	a.	NOUN
fnp-3500	135	75	mukhopadhyay2	mukhopadhyay2	NOUN
fnp-3500	135	76	,	,	PUNCT
fnp-3500	135	77	t.	t.	PROPN
fnp-3500	135	78	acker1	acker1	PROPN
fnp-3500	135	79	1	1	NUM
fnp-3500	135	80	justus	justus	PROPN
fnp-3500	135	81	-	-	PUNCT
fnp-3500	135	82	liebig	liebig	NOUN
fnp-3500	135	83	-	-	PUNCT
fnp-3500	135	84	university	university	NOUN
fnp-3500	135	85	gießen	gießen	NOUN
fnp-3500	135	86	,	,	PUNCT
fnp-3500	135	87	institute	institute	NOUN
fnp-3500	135	88	of	of	ADP
fnp-3500	135	89	neuropathology	neuropathology	NOUN
fnp-3500	135	90	,	,	PUNCT
fnp-3500	135	91	gießen	gießen	PROPN
fnp-3500	135	92	,	,	PUNCT
fnp-3500	135	93	germany	germany	PROPN
fnp-3500	135	94	2	2	NUM
fnp-3500	135	95	technical	technical	PROPN
fnp-3500	135	96	university	university	PROPN
fnp-3500	135	97	darmstadt	darmstadt	PROPN
fnp-3500	135	98	,	,	PUNCT
fnp-3500	135	99	medical	medical	ADJ
fnp-3500	135	100	and	and	CCONJ
fnp-3500	135	101	environmental	environmental	ADJ
fnp-3500	135	102	computing	computing	NOUN
fnp-3500	135	103	,	,	PUNCT
fnp-3500	135	104	darmstadt	darmstadt	PROPN
fnp-3500	135	105	,	,	PUNCT
fnp-3500	135	106	germany	germany	PROPN
fnp-3500	135	107	introduction	introduction	NOUN
fnp-3500	135	108	:	:	PUNCT
fnp-3500	135	109	current	current	ADJ
fnp-3500	135	110	studies	study	NOUN
fnp-3500	135	111	suggest	suggest	VERB
fnp-3500	135	112	that	that	SCONJ
fnp-3500	135	113	dna	dna	PROPN
fnp-3500	135	114	methylation	methylation	NOUN
fnp-3500	135	115	-	-	PUNCT
fnp-3500	135	116	based	base	VERB
fnp-3500	135	117	molecular	molecular	ADJ
fnp-3500	135	118	classification	classification	NOUN
fnp-3500	135	119	of	of	ADP
fnp-3500	135	120	meningioma	meningioma	NOUN
fnp-3500	135	121	has	have	VERB
fnp-3500	135	122	a	a	DET
fnp-3500	135	123	higher	high	ADJ
fnp-3500	135	124	predicting	predicting	NOUN
fnp-3500	135	125	power	power	NOUN
fnp-3500	135	126	for	for	ADP
fnp-3500	135	127	tumor	tumor	NOUN
fnp-3500	135	128	recurrence	recurrence	NOUN
fnp-3500	135	129	than	than	ADP
fnp-3500	135	130	the	the	DET
fnp-3500	135	131	current	current	ADJ
fnp-3500	135	132	histology	histology	NOUN
fnp-3500	135	133	-	-	PUNCT
fnp-3500	135	134	based	base	VERB
fnp-3500	135	135	who	who	PRON
fnp-3500	135	136	classification	classification	VERB
fnp-3500	135	137	.	.	PUNCT
fnp-3500	136	1	however	however	ADV
fnp-3500	136	2	dna	dna	PROPN
fnp-3500	136	3	methylation	methylation	NOUN
fnp-3500	136	4	profiling	profiling	NOUN
fnp-3500	136	5	is	be	AUX
fnp-3500	136	6	costly	costly	ADJ
fnp-3500	136	7	,	,	PUNCT
fnp-3500	136	8	time	time	NOUN
fnp-3500	136	9	-	-	PUNCT
fnp-3500	136	10	consuming	consume	VERB
fnp-3500	136	11	and	and	CCONJ
fnp-3500	136	12	not	not	PART
fnp-3500	136	13	widely	widely	ADV
fnp-3500	136	14	available	available	ADJ
fnp-3500	136	15	.	.	PUNCT
fnp-3500	137	1	therefore	therefore	ADV
fnp-3500	137	2	,	,	PUNCT
fnp-3500	137	3	an	an	DET
fnp-3500	137	4	ai	ai	NOUN
fnp-3500	137	5	-	-	PUNCT
fnp-3500	137	6	histology	histology	NOUN
fnp-3500	137	7	-	-	PUNCT
fnp-3500	137	8	based	base	VERB
fnp-3500	137	9	prediction	prediction	NOUN
fnp-3500	137	10	of	of	ADP
fnp-3500	137	11	the	the	DET
fnp-3500	137	12	six	six	NUM
fnp-3500	137	13	dna	dna	PROPN
fnp-3500	137	14	methylation	methylation	NOUN
fnp-3500	137	15	classes	class	NOUN
fnp-3500	137	16	would	would	AUX
fnp-3500	137	17	be	be	AUX
fnp-3500	137	18	very	very	ADV
fnp-3500	137	19	beneficial	beneficial	ADJ
fnp-3500	137	20	and	and	CCONJ
fnp-3500	137	21	could	could	AUX
fnp-3500	137	22	additionally	additionally	ADV
fnp-3500	137	23	complement	complement	VERB
fnp-3500	137	24	the	the	DET
fnp-3500	137	25	molecular	molecular	ADJ
fnp-3500	137	26	classification	classification	NOUN
fnp-3500	137	27	.	.	PUNCT
fnp-3500	138	1	deep	deep	ADJ
fnp-3500	138	2	neural	neural	ADJ
fnp-3500	138	3	networks	network	NOUN
fnp-3500	138	4	and	and	CCONJ
fnp-3500	138	5	their	their	PRON
fnp-3500	138	6	visual	visual	ADJ
fnp-3500	138	7	decoding	decode	VERB
fnp-3500	138	8	power	power	NOUN
fnp-3500	138	9	offer	offer	VERB
fnp-3500	138	10	a	a	DET
fnp-3500	138	11	promising	promising	ADJ
fnp-3500	138	12	tool	tool	NOUN
fnp-3500	138	13	to	to	PART
fnp-3500	138	14	address	address	VERB
fnp-3500	138	15	this	this	DET
fnp-3500	138	16	problem	problem	NOUN
fnp-3500	138	17	.	.	PUNCT
fnp-3500	139	1	objectives	objective	NOUN
fnp-3500	139	2	:	:	PUNCT
fnp-3500	139	3	our	our	PRON
fnp-3500	139	4	goal	goal	NOUN
fnp-3500	139	5	is	be	AUX
fnp-3500	139	6	to	to	PART
fnp-3500	139	7	predict	predict	VERB
fnp-3500	139	8	meningioma	meningioma	NOUN
fnp-3500	139	9	methylation	methylation	NOUN
fnp-3500	139	10	classes	class	NOUN
fnp-3500	139	11	using	use	VERB
fnp-3500	139	12	ai	ai	NOUN
fnp-3500	139	13	-	-	PUNCT
fnp-3500	139	14	assisted	assist	VERB
fnp-3500	139	15	digital	digital	ADJ
fnp-3500	139	16	histopathology	histopathology	NOUN
fnp-3500	139	17	.	.	PUNCT
fnp-3500	140	1	materials	material	NOUN
fnp-3500	140	2	and	and	CCONJ
fnp-3500	140	3	methods	method	NOUN
fnp-3500	140	4	:	:	PUNCT
fnp-3500	140	5	h&e	h&e	PROPN
fnp-3500	140	6	stained	stain	VERB
fnp-3500	140	7	histological	histological	ADJ
fnp-3500	140	8	slides	slide	NOUN
fnp-3500	140	9	were	be	AUX
fnp-3500	140	10	digitized	digitize	VERB
fnp-3500	140	11	with	with	ADP
fnp-3500	140	12	a	a	DET
fnp-3500	140	13	hamamatsu	hamamatsu	NOUN
fnp-3500	140	14	nanozoomer	nanozoomer	NOUN
fnp-3500	140	15	s360	s360	PROPN
fnp-3500	140	16	to	to	PART
fnp-3500	140	17	obtain	obtain	VERB
fnp-3500	140	18	whole	whole	ADJ
fnp-3500	140	19	slide	slide	NOUN
fnp-3500	140	20	images(wsi	images(wsi	NOUN
fnp-3500	140	21	)	)	PUNCT
fnp-3500	140	22	.	.	PUNCT
fnp-3500	141	1	multiple	multiple	ADJ
fnp-3500	141	2	image	image	NOUN
fnp-3500	141	3	patches	patch	NOUN
fnp-3500	141	4	per	per	ADP
fnp-3500	141	5	patient	patient	NOUN
fnp-3500	141	6	were	be	AUX
fnp-3500	141	7	extracted	extract	VERB
fnp-3500	141	8	and	and	CCONJ
fnp-3500	141	9	encoded	encode	VERB
fnp-3500	141	10	into	into	ADP
fnp-3500	141	11	feature	feature	NOUN
fnp-3500	141	12	space	space	NOUN
fnp-3500	141	13	using	use	VERB
fnp-3500	141	14	a	a	DET
fnp-3500	141	15	pre	pre	ADJ
fnp-3500	141	16	-	-	ADJ
fnp-3500	141	17	trained	train	VERB
fnp-3500	141	18	resnet50	resnet50	NOUN
fnp-3500	141	19	.	.	PUNCT
fnp-3500	142	1	those	those	DET
fnp-3500	142	2	features	feature	NOUN
fnp-3500	142	3	were	be	AUX
fnp-3500	142	4	aggregated	aggregate	VERB
fnp-3500	142	5	in	in	ADP
fnp-3500	142	6	a	a	DET
fnp-3500	142	7	multiple	multiple	ADJ
fnp-3500	142	8	instance	instance	NOUN
fnp-3500	142	9	learning	learn	VERB
fnp-3500	142	10	setting	set	VERB
fnp-3500	142	11	using	use	VERB
fnp-3500	142	12	an	an	DET
fnp-3500	142	13	attention	attention	NOUN
fnp-3500	142	14	network	network	NOUN
fnp-3500	142	15	to	to	PART
fnp-3500	142	16	predict	predict	VERB
fnp-3500	142	17	the	the	DET
fnp-3500	142	18	methylation	methylation	NOUN
fnp-3500	142	19	class	class	NOUN
fnp-3500	142	20	.	.	PUNCT
fnp-3500	143	1	results	result	NOUN
fnp-3500	143	2	:	:	PUNCT
fnp-3500	143	3	we	we	PRON
fnp-3500	143	4	have	have	AUX
fnp-3500	143	5	collected	collect	VERB
fnp-3500	143	6	wsi	wsi	PROPN
fnp-3500	143	7	data	datum	NOUN
fnp-3500	143	8	of	of	ADP
fnp-3500	143	9	167	167	NUM
fnp-3500	143	10	patients	patient	NOUN
fnp-3500	143	11	so	so	ADV
fnp-3500	143	12	far	far	ADV
fnp-3500	143	13	.	.	PUNCT
fnp-3500	144	1	most	most	ADJ
fnp-3500	144	2	specimens	specimen	NOUN
fnp-3500	144	3	belong	belong	VERB
fnp-3500	144	4	to	to	ADP
fnp-3500	144	5	the	the	DET
fnp-3500	144	6	most	most	ADV
fnp-3500	144	7	frequently	frequently	ADV
fnp-3500	144	8	diagnosed	diagnose	VERB
fnp-3500	144	9	methylation	methylation	NOUN
fnp-3500	144	10	subgroups	subgroup	NOUN
fnp-3500	144	11	,	,	PUNCT
fnp-3500	144	12	namely	namely	ADV
fnp-3500	144	13	benign-1	benign-1	NUM
fnp-3500	144	14	(	(	PUNCT
fnp-3500	144	15	n=36	n=36	PROPN
fnp-3500	144	16	)	)	PUNCT
fnp-3500	144	17	,	,	PUNCT
fnp-3500	144	18	benign-2	benign-2	NUM
fnp-3500	144	19	(	(	PUNCT
fnp-3500	144	20	n=55	n=55	ADV
fnp-3500	144	21	)	)	PUNCT
fnp-3500	144	22	and	and	CCONJ
fnp-3500	144	23	intermediate	intermediate	ADJ
fnp-3500	144	24	-	-	PUNCT
fnp-3500	144	25	a	a	DET
fnp-3500	144	26	(	(	PUNCT
fnp-3500	144	27	n=60	n=60	NOUN
fnp-3500	144	28	)	)	PUNCT
fnp-3500	144	29	.	.	PUNCT
fnp-3500	145	1	three	three	NUM
fnp-3500	145	2	separate	separate	ADJ
fnp-3500	145	3	two	two	NUM
fnp-3500	145	4	-	-	PUNCT
fnp-3500	145	5	class	class	NOUN
fnp-3500	145	6	classifications	classification	NOUN
fnp-3500	145	7	(	(	PUNCT
fnp-3500	145	8	benign-1	benign-1	NUM
fnp-3500	145	9	vs.	vs.	ADP
fnp-3500	145	10	benign-2	benign-2	NUM
fnp-3500	145	11	,	,	PUNCT
fnp-3500	145	12	benign-1	benign-1	NUM
fnp-3500	145	13	vs.	vs.	X
fnp-3500	145	14	intermediate	intermediate	ADJ
fnp-3500	145	15	-	-	PUNCT
fnp-3500	145	16	a	a	NOUN
fnp-3500	145	17	and	and	CCONJ
fnp-3500	145	18	benign-2	benign-2	NOUN
fnp-3500	145	19	vs.	vs.	X
fnp-3500	145	20	intermediate	intermediate	ADJ
fnp-3500	145	21	-	-	PUNCT
fnp-3500	145	22	a	a	NOUN
fnp-3500	145	23	)	)	PUNCT
fnp-3500	145	24	are	be	AUX
fnp-3500	145	25	currently	currently	ADV
fnp-3500	145	26	under	under	ADP
fnp-3500	145	27	development	development	NOUN
fnp-3500	145	28	.	.	PUNCT
fnp-3500	146	1	patients	patient	NOUN
fnp-3500	146	2	were	be	AUX
fnp-3500	146	3	allocated	allocate	VERB
fnp-3500	146	4	into	into	ADP
fnp-3500	146	5	training	training	NOUN
fnp-3500	146	6	,	,	PUNCT
fnp-3500	146	7	validation	validation	NOUN
fnp-3500	146	8	and	and	CCONJ
fnp-3500	146	9	test	test	NOUN
fnp-3500	146	10	sets	set	NOUN
fnp-3500	146	11	(	(	PUNCT
fnp-3500	146	12	0.7/0.1/0.2	0.7/0.1/0.2	NOUN
fnp-3500	146	13	)	)	PUNCT
fnp-3500	146	14	and	and	CCONJ
fnp-3500	146	15	we	we	PRON
fnp-3500	146	16	evaluated	evaluate	VERB
fnp-3500	146	17	the	the	DET
fnp-3500	146	18	patient	patient	NOUN
fnp-3500	146	19	-	-	PUNCT
fnp-3500	146	20	wise	wise	ADJ
fnp-3500	146	21	balanced	balanced	ADJ
fnp-3500	146	22	accuracy	accuracy	NOUN
fnp-3500	146	23	on	on	ADP
fnp-3500	146	24	the	the	DET
fnp-3500	146	25	test	test	NOUN
fnp-3500	146	26	set	set	VERB
fnp-3500	146	27	in	in	ADP
fnp-3500	146	28	a	a	DET
fnp-3500	146	29	5	5	NUM
fnp-3500	146	30	-	-	ADJ
fnp-3500	146	31	fold	fold	ADJ
fnp-3500	146	32	cross	cross	NOUN
fnp-3500	146	33	-	-	NOUN
fnp-3500	146	34	validation	validation	NOUN
fnp-3500	146	35	.	.	PUNCT
fnp-3500	147	1	in	in	ADP
fnp-3500	147	2	addition	addition	NOUN
fnp-3500	147	3	,	,	PUNCT
fnp-3500	147	4	the	the	DET
fnp-3500	147	5	attention	attention	NOUN
fnp-3500	147	6	weights	weight	VERB
fnp-3500	147	7	for	for	SCONJ
fnp-3500	147	8	the	the	DET
fnp-3500	147	9	image	image	NOUN
fnp-3500	147	10	patches	patch	NOUN
fnp-3500	147	11	of	of	ADP
fnp-3500	147	12	a	a	DET
fnp-3500	147	13	wsi	wsi	NOUN
fnp-3500	147	14	were	be	AUX
fnp-3500	147	15	visualized	visualize	VERB
fnp-3500	147	16	for	for	ADP
fnp-3500	147	17	interpretability	interpretability	NOUN
fnp-3500	147	18	.	.	PUNCT
fnp-3500	148	1	conclusion	conclusion	NOUN
fnp-3500	148	2	:	:	PUNCT
fnp-3500	148	3	we	we	PRON
fnp-3500	148	4	employ	employ	VERB
fnp-3500	148	5	a	a	DET
fnp-3500	148	6	framework	framework	NOUN
fnp-3500	148	7	for	for	ADP
fnp-3500	148	8	the	the	DET
fnp-3500	148	9	prediction	prediction	NOUN
fnp-3500	148	10	of	of	ADP
fnp-3500	148	11	methylation	methylation	NOUN
fnp-3500	148	12	classes	class	NOUN
fnp-3500	148	13	based	base	VERB
fnp-3500	148	14	on	on	ADP
fnp-3500	148	15	histological	histological	ADJ
fnp-3500	148	16	features	feature	NOUN
fnp-3500	148	17	.	.	PUNCT
fnp-3500	149	1	visualization	visualization	NOUN
fnp-3500	149	2	is	be	AUX
fnp-3500	149	3	used	use	VERB
fnp-3500	149	4	for	for	ADP
fnp-3500	149	5	an	an	DET
fnp-3500	149	6	enhanced	enhanced	ADJ
fnp-3500	149	7	interpretability	interpretability	NOUN
fnp-3500	149	8	of	of	ADP
fnp-3500	149	9	the	the	DET
fnp-3500	149	10	black	black	ADJ
fnp-3500	149	11	-	-	PUNCT
fnp-3500	149	12	box	box	NOUN
fnp-3500	149	13	network	network	NOUN
fnp-3500	149	14	.	.	PUNCT
fnp-3500	150	1	this	this	DET
fnp-3500	150	2	ai	ai	NOUN
fnp-3500	150	3	-	-	PUNCT
fnp-3500	150	4	framework	framework	NOUN
fnp-3500	150	5	may	may	AUX
fnp-3500	150	6	support	support	VERB
fnp-3500	150	7	,	,	PUNCT
fnp-3500	150	8	complement	complement	NOUN
fnp-3500	150	9	,	,	PUNCT
fnp-3500	150	10	and	and	CCONJ
fnp-3500	150	11	accelerate	accelerate	VERB
fnp-3500	150	12	meningioma	meningioma	NOUN
fnp-3500	150	13	classification	classification	NOUN
fnp-3500	150	14	in	in	ADP
fnp-3500	150	15	the	the	DET
fnp-3500	150	16	future	future	NOUN
fnp-3500	150	17	.	.	PUNCT
fnp-3500	150	18	  	  	SPACE
fnp-3500	151	1	muscle	muscle	NOUN
fnp-3500	151	2	&	&	CCONJ
fnp-3500	151	3	nerve	nerve	NOUN
fnp-3500	151	4	diseases	disease	NOUN
fnp-3500	151	5	mnd-01	mnd-01	NUM
fnp-3500	151	6	free	free	ADJ
fnp-3500	151	7	neuropathol	neuropathol	NOUN
fnp-3500	151	8	2:22:19	2:22:19	NUM
fnp-3500	151	9	in	in	ADP
fnp-3500	151	10	the	the	DET
fnp-3500	151	11	spotlight	spotlight	NOUN
fnp-3500	151	12	:	:	PUNCT
fnp-3500	151	13	nk	nk	PROPN
fnp-3500	151	14	cell	cell	NOUN
fnp-3500	151	15	receptors	receptor	NOUN
fnp-3500	151	16	in	in	ADP
fnp-3500	151	17	inclusion	inclusion	NOUN
fnp-3500	151	18	body	body	NOUN
fnp-3500	151	19	myositis	myositis	PROPN
fnp-3500	151	20	c.	c.	PROPN
fnp-3500	151	21	nelke1	nelke1	PROPN
fnp-3500	151	22	,	,	PUNCT
fnp-3500	151	23	m.	m.	NOUN
fnp-3500	151	24	pawlitzki2	pawlitzki2	PROPN
fnp-3500	151	25	,	,	PUNCT
fnp-3500	151	26	t.	t.	NOUN
fnp-3500	151	27	ruck1	ruck1	NOUN
fnp-3500	151	28	1	1	NUM
fnp-3500	151	29	university	university	NOUN
fnp-3500	151	30	hospital	hospital	NOUN
fnp-3500	151	31	duesseldorf	duesseldorf	PROPN
fnp-3500	151	32	,	,	PUNCT
fnp-3500	151	33	deparment	deparment	NOUN
fnp-3500	151	34	for	for	ADP
fnp-3500	151	35	neurology	neurology	NOUN
fnp-3500	151	36	,	,	PUNCT
fnp-3500	151	37	neurology	neurology	NOUN
fnp-3500	151	38	,	,	PUNCT
fnp-3500	151	39	düsseldorf	düsseldorf	PROPN
fnp-3500	151	40	,	,	PUNCT
fnp-3500	151	41	germany	germany	PROPN
fnp-3500	151	42	2	2	NUM
fnp-3500	151	43	university	university	NOUN
fnp-3500	151	44	hospital	hospital	NOUN
fnp-3500	151	45	münster	münster	NOUN
fnp-3500	151	46	,	,	PUNCT
fnp-3500	151	47	department	department	NOUN
fnp-3500	151	48	of	of	ADP
fnp-3500	151	49	neurology	neurology	NOUN
fnp-3500	151	50	with	with	ADP
fnp-3500	151	51	intitute	intitute	NOUN
fnp-3500	151	52	of	of	ADP
fnp-3500	151	53	translational	translational	ADJ
fnp-3500	151	54	neurology	neurology	NOUN
fnp-3500	151	55	,	,	PUNCT
fnp-3500	151	56	münster	münster	NOUN
fnp-3500	151	57	,	,	PUNCT
fnp-3500	151	58	germany	germany	PROPN
fnp-3500	151	59	introduction	introduction	NOUN
fnp-3500	151	60	:	:	PUNCT
fnp-3500	151	61	inclusion	inclusion	NOUN
fnp-3500	151	62	body	body	NOUN
fnp-3500	151	63	myositis	myositis	PROPN
fnp-3500	151	64	(	(	PUNCT
fnp-3500	151	65	ibm	ibm	PROPN
fnp-3500	151	66	)	)	PUNCT
fnp-3500	151	67	is	be	AUX
fnp-3500	151	68	the	the	DET
fnp-3500	151	69	most	most	ADV
fnp-3500	151	70	common	common	ADJ
fnp-3500	151	71	inflammatory	inflammatory	ADJ
fnp-3500	151	72	idiopathic	idiopathic	ADJ
fnp-3500	151	73	myopathy	myopathy	ADJ
fnp-3500	151	74	(	(	PUNCT
fnp-3500	151	75	iim	iim	NOUN
fnp-3500	151	76	)	)	PUNCT
fnp-3500	151	77	of	of	ADP
fnp-3500	151	78	old	old	ADJ
fnp-3500	151	79	age	age	NOUN
fnp-3500	151	80	.	.	PUNCT
fnp-3500	152	1	as	as	ADP
fnp-3500	152	2	of	of	ADP
fnp-3500	152	3	yet	yet	ADV
fnp-3500	152	4	,	,	PUNCT
fnp-3500	152	5	effective	effective	ADJ
fnp-3500	152	6	treatment	treatment	NOUN
fnp-3500	152	7	approaches	approach	NOUN
fnp-3500	152	8	are	be	AUX
fnp-3500	152	9	lacking	lack	VERB
fnp-3500	152	10	.	.	PUNCT
fnp-3500	153	1	a	a	DET
fnp-3500	153	2	deeper	deep	ADJ
fnp-3500	153	3	immunological	immunological	ADJ
fnp-3500	153	4	understanding	understanding	NOUN
fnp-3500	153	5	is	be	AUX
fnp-3500	153	6	necessary	necessary	ADJ
fnp-3500	153	7	to	to	PART
fnp-3500	153	8	overcome	overcome	VERB
fnp-3500	153	9	this	this	DET
fnp-3500	153	10	roadblock	roadblock	NOUN
fnp-3500	153	11	.	.	PUNCT
fnp-3500	154	1	as	as	SCONJ
fnp-3500	154	2	natural	natural	ADJ
fnp-3500	154	3	killer	killer	NOUN
fnp-3500	154	4	(	(	PUNCT
fnp-3500	154	5	nk	nk	PROPN
fnp-3500	154	6	)	)	PUNCT
fnp-3500	154	7	cells	cell	NOUN
fnp-3500	154	8	orchestrate	orchestrate	VERB
fnp-3500	154	9	the	the	DET
fnp-3500	154	10	extent	extent	NOUN
fnp-3500	154	11	of	of	ADP
fnp-3500	154	12	inflammatory	inflammatory	ADJ
fnp-3500	154	13	responses	response	NOUN
fnp-3500	154	14	by	by	ADP
fnp-3500	154	15	cytolytic	cytolytic	ADJ
fnp-3500	154	16	properties	property	NOUN
fnp-3500	154	17	in	in	ADP
fnp-3500	154	18	iim	iim	NOUN
fnp-3500	154	19	capable	capable	ADJ
fnp-3500	154	20	of	of	ADP
fnp-3500	154	21	inducing	induce	VERB
fnp-3500	154	22	bystander	bystander	NOUN
fnp-3500	154	23	self	self	NOUN
fnp-3500	154	24	-	-	PUNCT
fnp-3500	154	25	tissue	tissue	NOUN
fnp-3500	154	26	damage	damage	NOUN
fnp-3500	154	27	,	,	PUNCT
fnp-3500	154	28	we	we	PRON
fnp-3500	154	29	aimed	aim	VERB
fnp-3500	154	30	to	to	PART
fnp-3500	154	31	characterize	characterize	VERB
fnp-3500	154	32	nk	nk	PROPN
fnp-3500	154	33	cell	cell	NOUN
fnp-3500	154	34	patterns	pattern	NOUN
fnp-3500	154	35	in	in	ADP
fnp-3500	154	36	ibm	ibm	PROPN
fnp-3500	154	37	.	.	PUNCT
fnp-3500	155	1	objectives	objective	NOUN
fnp-3500	155	2	:	:	PUNCT
fnp-3500	155	3	to	to	PART
fnp-3500	155	4	determine	determine	VERB
fnp-3500	155	5	nk	nk	PROPN
fnp-3500	155	6	cell	cell	NOUN
fnp-3500	155	7	patterns	pattern	NOUN
fnp-3500	155	8	in	in	ADP
fnp-3500	155	9	ibm	ibm	PROPN
fnp-3500	155	10	and	and	CCONJ
fnp-3500	155	11	identify	identify	VERB
fnp-3500	155	12	drivers	driver	NOUN
fnp-3500	155	13	of	of	ADP
fnp-3500	155	14	nk	nk	PROPN
fnp-3500	155	15	cell	cell	NOUN
fnp-3500	155	16	activation	activation	NOUN
fnp-3500	155	17	.	.	PUNCT
fnp-3500	156	1	patients	patient	NOUN
fnp-3500	156	2	&	&	CCONJ
fnp-3500	156	3	methods	method	NOUN
fnp-3500	156	4	:	:	PUNCT
fnp-3500	156	5	we	we	PRON
fnp-3500	156	6	included	include	VERB
fnp-3500	156	7	20	20	NUM
fnp-3500	156	8	ibm	ibm	PROPN
fnp-3500	156	9	patients	patient	NOUN
fnp-3500	156	10	and	and	CCONJ
fnp-3500	156	11	20	20	NUM
fnp-3500	156	12	age	age	NOUN
fnp-3500	156	13	and	and	CCONJ
fnp-3500	156	14	sex	sex	NOUN
fnp-3500	156	15	matched	match	VERB
fnp-3500	156	16	non	non	ADJ
fnp-3500	156	17	diseased	disease	VERB
fnp-3500	156	18	controls	control	NOUN
fnp-3500	156	19	(	(	PUNCT
fnp-3500	156	20	ndc	ndc	NOUN
fnp-3500	156	21	)	)	PUNCT
fnp-3500	156	22	.	.	PUNCT
fnp-3500	157	1	peripheral	peripheral	ADJ
fnp-3500	157	2	blood	blood	NOUN
fnp-3500	157	3	was	be	AUX
fnp-3500	157	4	collected	collect	VERB
fnp-3500	157	5	and	and	CCONJ
fnp-3500	157	6	peripheral	peripheral	ADJ
fnp-3500	157	7	blood	blood	NOUN
fnp-3500	157	8	mononuclear	mononuclear	ADJ
fnp-3500	157	9	cells	cell	NOUN
fnp-3500	157	10	(	(	PUNCT
fnp-3500	157	11	pbmc	pbmc	NOUN
fnp-3500	157	12	)	)	PUNCT
fnp-3500	157	13	were	be	AUX
fnp-3500	157	14	isolated	isolate	VERB
fnp-3500	157	15	by	by	ADP
fnp-3500	157	16	density	density	NOUN
fnp-3500	157	17	gradient	gradient	NOUN
fnp-3500	157	18	centrifugation	centrifugation	NOUN
fnp-3500	157	19	.	.	PUNCT
fnp-3500	158	1	differences	difference	NOUN
fnp-3500	158	2	between	between	ADP
fnp-3500	158	3	groups	group	NOUN
fnp-3500	158	4	were	be	AUX
fnp-3500	158	5	analyzed	analyze	VERB
fnp-3500	158	6	using	use	VERB
fnp-3500	158	7	unpaired	unpaired	ADJ
fnp-3500	158	8	student"s	student"s	PROPN
fnp-3500	158	9	t	t	PROPN
fnp-3500	158	10	test	test	NOUN
fnp-3500	158	11	or	or	CCONJ
fnp-3500	158	12	mann	mann	PROPN
fnp-3500	158	13	–	–	PUNCT
fnp-3500	158	14	whitney	whitney	PROPN
fnp-3500	158	15	-	-	PUNCT
fnp-3500	158	16	u	u	PROPN
fnp-3500	158	17	test	test	NOUN
fnp-3500	158	18	as	as	ADP
fnp-3500	158	19	appropriate	appropriate	ADJ
fnp-3500	158	20	.	.	PUNCT
fnp-3500	159	1	anti	anti	ADJ
fnp-3500	159	2	-	-	ADJ
fnp-3500	159	3	cn-1a	cn-1a	ADJ
fnp-3500	159	4	-	-	PUNCT
fnp-3500	159	5	antibodies	antibody	NOUN
fnp-3500	159	6	were	be	AUX
fnp-3500	159	7	detected	detect	VERB
fnp-3500	159	8	in	in	ADP
fnp-3500	159	9	patient	patient	ADJ
fnp-3500	159	10	serum	serum	NOUN
fnp-3500	159	11	using	use	VERB
fnp-3500	159	12	the	the	DET
fnp-3500	159	13	euroimmun	euroimmun	NOUN
fnp-3500	159	14	immunoassay	immunoassay	PROPN
fnp-3500	159	15	.	.	PUNCT
fnp-3500	160	1	results	result	NOUN
fnp-3500	160	2	:	:	PUNCT
fnp-3500	160	3	the	the	DET
fnp-3500	160	4	activated	activate	VERB
fnp-3500	160	5	cd56dim	cd56dim	PROPN
fnp-3500	160	6	population	population	NOUN
fnp-3500	160	7	was	be	AUX
fnp-3500	160	8	reduced	reduce	VERB
fnp-3500	160	9	in	in	ADP
fnp-3500	160	10	peripheral	peripheral	ADJ
fnp-3500	160	11	blood	blood	NOUN
fnp-3500	160	12	of	of	ADP
fnp-3500	160	13	ibm	ibm	PROPN
fnp-3500	160	14	patients	patient	NOUN
fnp-3500	160	15	as	as	SCONJ
fnp-3500	160	16	compared	compare	VERB
fnp-3500	160	17	to	to	ADP
fnp-3500	160	18	controls	control	NOUN
fnp-3500	160	19	.	.	PUNCT
fnp-3500	161	1	comparing	compare	VERB
fnp-3500	161	2	surface	surface	NOUN
fnp-3500	161	3	expression	expression	NOUN
fnp-3500	161	4	as	as	SCONJ
fnp-3500	161	5	measured	measure	VERB
fnp-3500	161	6	by	by	ADP
fnp-3500	161	7	mean	mean	ADJ
fnp-3500	161	8	fluorescence	fluorescence	NOUN
fnp-3500	161	9	intensity	intensity	NOUN
fnp-3500	161	10	,	,	PUNCT
fnp-3500	161	11	we	we	PRON
fnp-3500	161	12	observed	observe	VERB
fnp-3500	161	13	a	a	DET
fnp-3500	161	14	significant	significant	ADJ
fnp-3500	161	15	increase	increase	NOUN
fnp-3500	161	16	of	of	ADP
fnp-3500	161	17	nkg2a	nkg2a	NUM
fnp-3500	161	18	and	and	CCONJ
fnp-3500	161	19	nkg2d	nkg2d	PROPN
fnp-3500	161	20	levels	level	NOUN
fnp-3500	161	21	on	on	ADP
fnp-3500	161	22	the	the	DET
fnp-3500	161	23	cd56dim	cd56dim	PROPN
fnp-3500	161	24	nk	nk	PROPN
fnp-3500	161	25	cell	cell	NOUN
fnp-3500	161	26	subset	subset	VERB
fnp-3500	161	27	in	in	ADP
fnp-3500	161	28	ibm	ibm	PROPN
fnp-3500	161	29	patients	patient	NOUN
fnp-3500	161	30	as	as	SCONJ
fnp-3500	161	31	compared	compare	VERB
fnp-3500	161	32	to	to	ADP
fnp-3500	161	33	ndc	ndc	PROPN
fnp-3500	161	34	.	.	PUNCT
fnp-3500	162	1	other	other	ADJ
fnp-3500	162	2	surface	surface	NOUN
fnp-3500	162	3	receptors	receptor	NOUN
fnp-3500	162	4	remained	remain	VERB
fnp-3500	162	5	unchanged	unchanged	ADJ
fnp-3500	162	6	.	.	PUNCT
fnp-3500	163	1	next	next	ADV
fnp-3500	163	2	,	,	PUNCT
fnp-3500	163	3	we	we	PRON
fnp-3500	163	4	were	be	AUX
fnp-3500	163	5	interested	interested	ADJ
fnp-3500	163	6	whether	whether	SCONJ
fnp-3500	163	7	the	the	DET
fnp-3500	163	8	antibody	antibody	NOUN
fnp-3500	163	9	status	status	NOUN
fnp-3500	163	10	of	of	ADP
fnp-3500	163	11	ibm	ibm	PROPN
fnp-3500	163	12	patients	patient	NOUN
fnp-3500	163	13	affects	affect	VERB
fnp-3500	163	14	expression	expression	NOUN
fnp-3500	163	15	of	of	ADP
fnp-3500	163	16	surface	surface	NOUN
fnp-3500	163	17	receptors	receptor	NOUN
fnp-3500	163	18	.	.	PUNCT
fnp-3500	164	1	consequently	consequently	ADV
fnp-3500	164	2	,	,	PUNCT
fnp-3500	164	3	comparison	comparison	NOUN
fnp-3500	164	4	of	of	ADP
fnp-3500	164	5	anti	anti	ADJ
fnp-3500	164	6	-	-	ADJ
fnp-3500	164	7	cn-1a	cn-1a	ADJ
fnp-3500	164	8	positive	positive	ADJ
fnp-3500	164	9	and	and	CCONJ
fnp-3500	164	10	anti	anti	ADJ
fnp-3500	164	11	-	-	ADJ
fnp-3500	164	12	cn-1a	cn-1a	ADJ
fnp-3500	164	13	negative	negative	ADJ
fnp-3500	164	14	patients	patient	NOUN
fnp-3500	164	15	revealed	reveal	VERB
fnp-3500	164	16	that	that	SCONJ
fnp-3500	164	17	nkg2a	nkg2a	NUM
fnp-3500	164	18	level	level	NOUN
fnp-3500	164	19	do	do	AUX
fnp-3500	164	20	not	not	PART
fnp-3500	164	21	differ	differ	VERB
fnp-3500	164	22	,	,	PUNCT
fnp-3500	164	23	while	while	SCONJ
fnp-3500	164	24	increased	increased	ADJ
fnp-3500	164	25	nkg2d	nkg2d	PROPN
fnp-3500	164	26	levels	level	NOUN
fnp-3500	164	27	were	be	AUX
fnp-3500	164	28	associated	associate	VERB
fnp-3500	164	29	with	with	ADP
fnp-3500	164	30	anti	anti	ADJ
fnp-3500	164	31	-	-	ADJ
fnp-3500	164	32	cn-1a	cn-1a	ADJ
fnp-3500	164	33	-	-	PUNCT
fnp-3500	164	34	ab	ab	NOUN
fnp-3500	164	35	positivity	positivity	NOUN
fnp-3500	164	36	.	.	PUNCT
fnp-3500	165	1	conclusion	conclusion	NOUN
fnp-3500	165	2	:	:	PUNCT
fnp-3500	165	3	here	here	ADV
fnp-3500	165	4	,	,	PUNCT
fnp-3500	165	5	we	we	PRON
fnp-3500	165	6	report	report	VERB
fnp-3500	165	7	distinct	distinct	ADJ
fnp-3500	165	8	nk	nk	PROPN
fnp-3500	165	9	cell	cell	NOUN
fnp-3500	165	10	patterns	pattern	NOUN
fnp-3500	165	11	in	in	ADP
fnp-3500	165	12	ibm	ibm	PROPN
fnp-3500	165	13	patients	patient	NOUN
fnp-3500	165	14	.	.	PUNCT
fnp-3500	166	1	activated	activate	VERB
fnp-3500	166	2	cd56dim	cd56dim	PROPN
fnp-3500	166	3	nk	nk	PROPN
fnp-3500	166	4	cells	cell	NOUN
fnp-3500	166	5	are	be	AUX
fnp-3500	166	6	reduced	reduce	VERB
fnp-3500	166	7	in	in	ADP
fnp-3500	166	8	peripheral	peripheral	ADJ
fnp-3500	166	9	blood	blood	NOUN
fnp-3500	166	10	as	as	SCONJ
fnp-3500	166	11	compared	compare	VERB
fnp-3500	166	12	to	to	ADP
fnp-3500	166	13	ndc	ndc	PROPN
fnp-3500	166	14	.	.	PUNCT
fnp-3500	166	15	nkg2a	nkg2a	PROPN
fnp-3500	166	16	and	and	CCONJ
fnp-3500	166	17	nkg2d	nkg2d	PROPN
fnp-3500	166	18	levels	level	NOUN
fnp-3500	166	19	are	be	AUX
fnp-3500	166	20	increased	increase	VERB
fnp-3500	166	21	on	on	ADP
fnp-3500	166	22	cd56dim	cd56dim	PROPN
fnp-3500	166	23	nk	nk	PROPN
fnp-3500	166	24	cells	cell	NOUN
fnp-3500	166	25	.	.	PUNCT
fnp-3500	167	1	lastly	lastly	ADV
fnp-3500	167	2	,	,	PUNCT
fnp-3500	167	3	increased	increase	VERB
fnp-3500	167	4	nkg2d	nkg2d	PROPN
fnp-3500	167	5	levels	level	NOUN
fnp-3500	167	6	were	be	AUX
fnp-3500	167	7	associated	associate	VERB
fnp-3500	167	8	with	with	ADP
fnp-3500	167	9	anti	anti	ADJ
fnp-3500	167	10	-	-	ADJ
fnp-3500	167	11	cn-1	cn-1	ADJ
fnp-3500	167	12	-	-	PUNCT
fnp-3500	167	13	ab	ab	NOUN
fnp-3500	167	14	serostatus	serostatus	NOUN
fnp-3500	167	15	.	.	PUNCT
fnp-3500	168	1	fig	fig	NOUN
fnp-3500	168	2	.	.	PUNCT
fnp-3500	169	1	1	1	NUM
fnp-3500	169	2	fig	fig	NOUN
fnp-3500	169	3	.	.	PUNCT
fnp-3500	170	1	2	2	NUM
fnp-3500	170	2	  	  	SPACE
fnp-3500	170	3	mnd-02	mnd-02	NOUN
fnp-3500	170	4	free	free	ADJ
fnp-3500	170	5	neuropathol	neuropathol	NOUN
fnp-3500	170	6	2:22:21	2:22:21	NUM
fnp-3500	170	7	mutations	mutation	NOUN
fnp-3500	170	8	in	in	ADP
fnp-3500	170	9	bves	bve	NOUN
fnp-3500	170	10	can	can	AUX
fnp-3500	170	11	lead	lead	VERB
fnp-3500	170	12	to	to	ADP
fnp-3500	170	13	early	early	ADJ
fnp-3500	170	14	onset	onset	NOUN
fnp-3500	170	15	of	of	ADP
fnp-3500	170	16	cardiac	cardiac	ADJ
fnp-3500	170	17	symptoms	symptom	NOUN
fnp-3500	170	18	without	without	ADP
fnp-3500	170	19	clinical	clinical	ADJ
fnp-3500	170	20	signs	sign	NOUN
fnp-3500	170	21	of	of	ADP
fnp-3500	170	22	muscle	muscle	NOUN
fnp-3500	170	23	dystrophy	dystrophy	NOUN
fnp-3500	170	24	in	in	ADP
fnp-3500	170	25	children	child	NOUN
fnp-3500	170	26	and	and	CCONJ
fnp-3500	170	27	adolescents	adolescent	NOUN
fnp-3500	170	28	a.	a.	PROPN
fnp-3500	170	29	gangfuß1	gangfuß1	PROPN
fnp-3500	170	30	,	,	PUNCT
fnp-3500	170	31	a.	a.	PROPN
fnp-3500	170	32	hentschel2	hentschel2	PROPN
fnp-3500	170	33	,	,	PUNCT
fnp-3500	170	34	m.	m.	PROPN
fnp-3500	170	35	gonzales3	gonzales3	PROPN
fnp-3500	170	36	,	,	PUNCT
fnp-3500	170	37	a.	a.	PROPN
fnp-3500	170	38	schönecker4	schönecker4	PROPN
fnp-3500	170	39	,	,	PUNCT
fnp-3500	170	40	a.	a.	PROPN
fnp-3500	170	41	töpf5	töpf5	PROPN
fnp-3500	170	42	,	,	PUNCT
fnp-3500	170	43	a.	a.	PROPN
fnp-3500	170	44	sickmann2	sickmann2	PROPN
fnp-3500	170	45	,	,	PUNCT
fnp-3500	170	46	a.	a.	PROPN
fnp-3500	170	47	nishimura6	nishimura6	PROPN
fnp-3500	170	48	,	,	PUNCT
fnp-3500	170	49	u.	u.	PROPN
fnp-3500	170	50	schara	schara	PROPN
fnp-3500	170	51	-	-	PUNCT
fnp-3500	170	52	schmidt1	schmidt1	PROPN
fnp-3500	170	53	,	,	PUNCT
fnp-3500	170	54	a.	a.	PROPN
fnp-3500	170	55	hahn7	hahn7	PROPN
fnp-3500	170	56	,	,	PUNCT
fnp-3500	170	57	a.	a.	PROPN
fnp-3500	170	58	roos1	roos1	PROPN
fnp-3500	170	59	,	,	PUNCT
fnp-3500	170	60	a.	a.	PROPN
fnp-3500	170	61	schänzer6	schänzer6	PROPN
fnp-3500	170	62	1	1	NUM
fnp-3500	170	63	university	university	NOUN
fnp-3500	170	64	duisburg	duisburg	PROPN
fnp-3500	170	65	-	-	PUNCT
fnp-3500	170	66	essen	essen	NOUN
fnp-3500	170	67	,	,	PUNCT
fnp-3500	170	68	department	department	NOUN
fnp-3500	170	69	of	of	ADP
fnp-3500	170	70	pediatric	pediatric	ADJ
fnp-3500	170	71	neurology	neurology	NOUN
fnp-3500	170	72	,	,	PUNCT
fnp-3500	170	73	centre	centre	NOUN
fnp-3500	170	74	for	for	ADP
fnp-3500	170	75	neuromuscular	neuromuscular	ADJ
fnp-3500	170	76	disorders	disorder	NOUN
fnp-3500	170	77	,	,	PUNCT
fnp-3500	170	78	centre	centre	NOUN
fnp-3500	170	79	for	for	ADP
fnp-3500	170	80	translational	translational	ADJ
fnp-3500	170	81	neuroand	neuroand	ADJ
fnp-3500	170	82	behavioral	behavioral	ADJ
fnp-3500	170	83	sciences	sciences	PROPN
fnp-3500	170	84	,	,	PUNCT
fnp-3500	170	85	essen	essen	PROPN
fnp-3500	170	86	,	,	PUNCT
fnp-3500	170	87	germany	germany	PROPN
fnp-3500	170	88	2	2	NUM
fnp-3500	170	89	leibniz	leibniz	PROPN
fnp-3500	170	90	-	-	PUNCT
fnp-3500	170	91	institut	institut	PROPN
fnp-3500	170	92	für	für	PROPN
fnp-3500	170	93	analytische	analytische	PROPN
fnp-3500	170	94	wissenschaften	wissenschaften	VERB
fnp-3500	170	95	isas	isas	PROPN
fnp-3500	171	1	e.v	e.v	PROPN
fnp-3500	171	2	.	.	PROPN
fnp-3500	171	3	,	,	PUNCT
fnp-3500	171	4	dortmund	dortmund	PROPN
fnp-3500	171	5	,	,	PUNCT
fnp-3500	171	6	germany	germany	PROPN
fnp-3500	171	7	3	3	NUM
fnp-3500	171	8	justus	justus	PROPN
fnp-3500	171	9	-	-	PUNCT
fnp-3500	171	10	liebig	liebig	NOUN
fnp-3500	171	11	-	-	PUNCT
fnp-3500	171	12	university	university	NOUN
fnp-3500	171	13	gießen	gießen	NOUN
fnp-3500	171	14	,	,	PUNCT
fnp-3500	171	15	pediatric	pediatric	ADJ
fnp-3500	171	16	heart	heart	NOUN
fnp-3500	171	17	center	center	NOUN
fnp-3500	171	18	,	,	PUNCT
fnp-3500	171	19	gießen	gießen	PROPN
fnp-3500	171	20	,	,	PUNCT
fnp-3500	171	21	germany	germany	PROPN
fnp-3500	171	22	4	4	NUM
fnp-3500	171	23	university	university	NOUN
fnp-3500	171	24	duisburg	duisburg	PROPN
fnp-3500	171	25	-	-	PUNCT
fnp-3500	171	26	essen	essen	NOUN
fnp-3500	171	27	,	,	PUNCT
fnp-3500	171	28	department	department	NOUN
fnp-3500	171	29	of	of	ADP
fnp-3500	171	30	pediatric	pediatric	ADJ
fnp-3500	171	31	cardiology	cardiology	NOUN
fnp-3500	171	32	,	,	PUNCT
fnp-3500	171	33	essen	essen	PROPN
fnp-3500	171	34	,	,	PUNCT
fnp-3500	171	35	germany	germany	PROPN
fnp-3500	171	36	5	5	NUM
fnp-3500	171	37	newcastle	newcastle	PROPN
fnp-3500	171	38	university	university	PROPN
fnp-3500	171	39	and	and	CCONJ
fnp-3500	171	40	newcastle	newcastle	PROPN
fnp-3500	171	41	hospitals	hospitals	PROPN
fnp-3500	171	42	nhs	nhs	PROPN
fnp-3500	171	43	foundation	foundation	PROPN
fnp-3500	171	44	trust	trust	PROPN
fnp-3500	171	45	,	,	PUNCT
fnp-3500	171	46	the	the	DET
fnp-3500	171	47	john	john	PROPN
fnp-3500	171	48	walton	walton	PROPN
fnp-3500	171	49	muscular	muscular	ADJ
fnp-3500	171	50	dystrophy	dystrophy	NOUN
fnp-3500	171	51	research	research	NOUN
fnp-3500	171	52	centre	centre	NOUN
fnp-3500	171	53	,	,	PUNCT
fnp-3500	171	54	translational	translational	ADJ
fnp-3500	171	55	and	and	CCONJ
fnp-3500	171	56	clinical	clinical	ADJ
fnp-3500	171	57	research	research	PROPN
fnp-3500	171	58	institute	institute	PROPN
fnp-3500	171	59	,	,	PUNCT
fnp-3500	171	60	newcastle	newcastle	PROPN
fnp-3500	171	61	upon	upon	SCONJ
fnp-3500	171	62	tyne	tyne	PROPN
fnp-3500	171	63	,	,	PUNCT
fnp-3500	171	64	united	united	PROPN
fnp-3500	171	65	kingdom	kingdom	PROPN
fnp-3500	171	66	6	6	NUM
fnp-3500	171	67	newcastle	newcastle	PROPN
fnp-3500	171	68	university	university	PROPN
fnp-3500	171	69	and	and	CCONJ
fnp-3500	171	70	newcastle	newcastle	PROPN
fnp-3500	171	71	hospitals	hospitals	PROPN
fnp-3500	171	72	nhs	nhs	PROPN
fnp-3500	171	73	foundation	foundation	PROPN
fnp-3500	171	74	trust	trust	PROPN
fnp-3500	171	75	,	,	PUNCT
fnp-3500	171	76	the	the	DET
fnp-3500	171	77	john	john	PROPN
fnp-3500	171	78	walton	walton	PROPN
fnp-3500	171	79	muscular	muscular	ADJ
fnp-3500	171	80	dystrophy	dystrophy	NOUN
fnp-3500	171	81	research	research	NOUN
fnp-3500	171	82	centre	centre	NOUN
fnp-3500	171	83	,	,	PUNCT
fnp-3500	171	84	translational	translational	ADJ
fnp-3500	171	85	and	and	CCONJ
fnp-3500	171	86	clinical	clinical	ADJ
fnp-3500	171	87	research	research	PROPN
fnp-3500	171	88	institute	institute	PROPN
fnp-3500	171	89	,	,	PUNCT
fnp-3500	171	90	newcastle	newcastle	PROPN
fnp-3500	171	91	upon	upon	SCONJ
fnp-3500	171	92	tyne	tyne	PROPN
fnp-3500	171	93	,	,	PUNCT
fnp-3500	171	94	united	united	PROPN
fnp-3500	171	95	kingdom	kingdom	PROPN
fnp-3500	171	96	7	7	NUM
fnp-3500	171	97	justus	justus	PROPN
fnp-3500	171	98	-	-	PUNCT
fnp-3500	171	99	liebig	liebig	NOUN
fnp-3500	171	100	-	-	PUNCT
fnp-3500	171	101	university	university	NOUN
fnp-3500	171	102	gießen	gießen	NOUN
fnp-3500	171	103	,	,	PUNCT
fnp-3500	171	104	department	department	NOUN
fnp-3500	171	105	of	of	ADP
fnp-3500	171	106	child	child	NOUN
fnp-3500	171	107	neurology	neurology	NOUN
fnp-3500	171	108	,	,	PUNCT
fnp-3500	171	109	gießen	gießen	PROPN
fnp-3500	171	110	,	,	PUNCT
fnp-3500	171	111	germany	germany	PROPN
fnp-3500	171	112	introduction	introduction	NOUN
fnp-3500	171	113	:	:	PUNCT
fnp-3500	171	114	limb	limb	NOUN
fnp-3500	171	115	-	-	PUNCT
fnp-3500	171	116	girdle	girdle	NOUN
fnp-3500	171	117	muscular	muscular	ADJ
fnp-3500	171	118	dystrophies	dystrophy	NOUN
fnp-3500	171	119	occur	occur	VERB
fnp-3500	171	120	in	in	ADP
fnp-3500	171	121	children	child	NOUN
fnp-3500	171	122	and	and	CCONJ
fnp-3500	171	123	adults	adult	NOUN
fnp-3500	171	124	and	and	CCONJ
fnp-3500	171	125	may	may	AUX
fnp-3500	171	126	be	be	AUX
fnp-3500	171	127	associated	associate	VERB
fnp-3500	171	128	with	with	ADP
fnp-3500	171	129	a	a	DET
fnp-3500	171	130	high	high	ADJ
fnp-3500	171	131	variability	variability	NOUN
fnp-3500	171	132	of	of	ADP
fnp-3500	171	133	the	the	DET
fnp-3500	171	134	clinical	clinical	ADJ
fnp-3500	171	135	phenotype	phenotype	NOUN
fnp-3500	171	136	.	.	PUNCT
fnp-3500	172	1	in	in	ADP
fnp-3500	172	2	some	some	DET
fnp-3500	172	3	subtypes	subtype	NOUN
fnp-3500	172	4	,	,	PUNCT
fnp-3500	172	5	cardiac	cardiac	ADJ
fnp-3500	172	6	involvement	involvement	NOUN
fnp-3500	172	7	is	be	AUX
fnp-3500	172	8	the	the	DET
fnp-3500	172	9	first	first	ADJ
fnp-3500	172	10	and	and	CCONJ
fnp-3500	172	11	thus	thus	ADV
fnp-3500	172	12	key	key	ADJ
fnp-3500	172	13	symptom	symptom	NOUN
fnp-3500	172	14	.	.	PUNCT
fnp-3500	173	1	recently	recently	ADV
fnp-3500	173	2	,	,	PUNCT
fnp-3500	173	3	blood	blood	NOUN
fnp-3500	173	4	vessel	vessel	NOUN
fnp-3500	173	5	endothelial	endothelial	ADJ
fnp-3500	173	6	substance	substance	NOUN
fnp-3500	173	7	(	(	PUNCT
fnp-3500	173	8	bves	bve	NOUN
fnp-3500	173	9	)	)	PUNCT
fnp-3500	173	10	,	,	PUNCT
fnp-3500	173	11	a	a	DET
fnp-3500	173	12	gene	gene	NOUN
fnp-3500	173	13	encoding	encode	VERB
fnp-3500	173	14	popeye	popeye	NOUN
fnp-3500	173	15	domain	domain	NOUN
fnp-3500	173	16	containing	contain	VERB
fnp-3500	173	17	protein	protein	NOUN
fnp-3500	173	18	1	1	NUM
fnp-3500	173	19	(	(	PUNCT
fnp-3500	173	20	popdc1	popdc1	PROPN
fnp-3500	173	21	)	)	PUNCT
fnp-3500	173	22	,	,	PUNCT
fnp-3500	173	23	has	have	AUX
fnp-3500	173	24	been	be	AUX
fnp-3500	173	25	implicated	implicate	VERB
fnp-3500	173	26	as	as	ADP
fnp-3500	173	27	a	a	DET
fnp-3500	173	28	causative	causative	NOUN
fnp-3500	173	29	for	for	ADP
fnp-3500	173	30	limb	limb	NOUN
fnp-3500	173	31	-	-	PUNCT
fnp-3500	173	32	girdle	girdle	NOUN
fnp-3500	173	33	dystrophy	dystrophy	NOUN
fnp-3500	173	34	type	type	NOUN
fnp-3500	173	35	r25	r25	PROPN
fnp-3500	173	36	(	(	PUNCT
fnp-3500	173	37	lgmdr25	lgmdr25	NOUN
fnp-3500	173	38	)	)	PUNCT
fnp-3500	173	39	,	,	PUNCT
fnp-3500	173	40	associated	associate	VERB
fnp-3500	173	41	with	with	ADP
fnp-3500	173	42	cardiac	cardiac	ADJ
fnp-3500	173	43	arrhythmia	arrhythmia	NOUN
fnp-3500	173	44	and	and	CCONJ
fnp-3500	173	45	variable	variable	ADJ
fnp-3500	173	46	skeletal	skeletal	ADJ
fnp-3500	173	47	muscle	muscle	NOUN
fnp-3500	173	48	involvement	involvement	NOUN
fnp-3500	173	49	.	.	PUNCT
fnp-3500	174	1	until	until	ADP
fnp-3500	174	2	today	today	NOUN
fnp-3500	174	3	,	,	PUNCT
fnp-3500	174	4	only	only	ADV
fnp-3500	174	5	10	10	NUM
fnp-3500	174	6	adult	adult	NOUN
fnp-3500	174	7	patients	patient	NOUN
fnp-3500	174	8	with	with	ADP
fnp-3500	174	9	this	this	DET
fnp-3500	174	10	rare	rare	ADJ
fnp-3500	174	11	autosomal	autosomal	ADJ
fnp-3500	174	12	recessive	recessive	ADJ
fnp-3500	174	13	lgmd	lgmd	NOUN
fnp-3500	174	14	have	have	AUX
fnp-3500	174	15	been	be	AUX
fnp-3500	174	16	described	describe	VERB
fnp-3500	174	17	.	.	PUNCT
fnp-3500	175	1	objectives	objective	NOUN
fnp-3500	175	2	:	:	PUNCT
fnp-3500	175	3	with	with	ADP
fnp-3500	175	4	this	this	DET
fnp-3500	175	5	study	study	NOUN
fnp-3500	175	6	,	,	PUNCT
fnp-3500	175	7	we	we	PRON
fnp-3500	175	8	aim	aim	VERB
fnp-3500	175	9	to	to	PART
fnp-3500	175	10	broaden	broaden	VERB
fnp-3500	175	11	the	the	DET
fnp-3500	175	12	phenotypic	phenotypic	ADJ
fnp-3500	175	13	spectrum	spectrum	NOUN
fnp-3500	175	14	and	and	CCONJ
fnp-3500	175	15	improve	improve	VERB
fnp-3500	175	16	the	the	DET
fnp-3500	175	17	pathophysiological	pathophysiological	ADJ
fnp-3500	175	18	understanding	understanding	NOUN
fnp-3500	175	19	of	of	ADP
fnp-3500	175	20	lgmdr25	lgmdr25	NOUN
fnp-3500	175	21	.	.	PUNCT
fnp-3500	176	1	materials	material	NOUN
fnp-3500	176	2	&	&	CCONJ
fnp-3500	176	3	methods	method	NOUN
fnp-3500	176	4	:	:	PUNCT
fnp-3500	176	5	hence	hence	ADV
fnp-3500	176	6	,	,	PUNCT
fnp-3500	176	7	we	we	PRON
fnp-3500	176	8	describe	describe	VERB
fnp-3500	176	9	the	the	DET
fnp-3500	176	10	clinical	clinical	ADJ
fnp-3500	176	11	phenotype	phenotype	NOUN
fnp-3500	176	12	of	of	ADP
fnp-3500	176	13	four	four	NUM
fnp-3500	176	14	affected	affected	ADJ
fnp-3500	176	15	children	child	NOUN
fnp-3500	176	16	of	of	ADP
fnp-3500	176	17	two	two	NUM
fnp-3500	176	18	families	family	NOUN
fnp-3500	176	19	with	with	ADP
fnp-3500	176	20	homozygous	homozygous	ADJ
fnp-3500	176	21	variants	variant	NOUN
fnp-3500	176	22	(	(	PUNCT
fnp-3500	176	23	c.457	c.457	PROPN
fnp-3500	176	24	>	>	X
fnp-3500	176	25	t	t	PROPN
fnp-3500	176	26	;	;	PUNCT
fnp-3500	176	27	p.gln153ter	p.gln153ter	NOUN
fnp-3500	176	28	and	and	CCONJ
fnp-3500	176	29	c.578t	c.578t	PROPN
fnp-3500	176	30	>	>	ADJ
fnp-3500	176	31	g	g	PROPN
fnp-3500	176	32	,	,	PUNCT
fnp-3500	176	33	p.ile193ser	p.ile193ser	NOUN
fnp-3500	176	34	)	)	PUNCT
fnp-3500	176	35	in	in	ADP
fnp-3500	176	36	blood	blood	NOUN
fnp-3500	176	37	vessel	vessel	NOUN
fnp-3500	176	38	endothelial	endothelial	ADJ
fnp-3500	176	39	substance	substance	NOUN
fnp-3500	176	40	(	(	PUNCT
fnp-3500	176	41	bves	bve	NOUN
fnp-3500	176	42	)	)	PUNCT
fnp-3500	176	43	.	.	PUNCT
fnp-3500	177	1	additionally	additionally	ADV
fnp-3500	177	2	,	,	PUNCT
fnp-3500	177	3	we	we	PRON
fnp-3500	177	4	performed	perform	VERB
fnp-3500	177	5	detailed	detailed	ADJ
fnp-3500	177	6	muscle	muscle	NOUN
fnp-3500	177	7	biopsy	biopsy	NOUN
fnp-3500	177	8	analysis	analysis	NOUN
fnp-3500	177	9	from	from	ADP
fnp-3500	177	10	two	two	NUM
fnp-3500	177	11	affected	affected	ADJ
fnp-3500	177	12	patients	patient	NOUN
fnp-3500	177	13	including	include	VERB
fnp-3500	177	14	immunofluorescence	immunofluorescence	NOUN
fnp-3500	177	15	,	,	PUNCT
fnp-3500	177	16	electron	electron	NOUN
fnp-3500	177	17	microscopic	microscopic	ADJ
fnp-3500	177	18	and	and	CCONJ
fnp-3500	177	19	proteomic	proteomic	ADJ
fnp-3500	177	20	studies	study	NOUN
fnp-3500	177	21	.	.	PUNCT
fnp-3500	178	1	results	result	NOUN
fnp-3500	178	2	:	:	PUNCT
fnp-3500	178	3	highly	highly	ADV
fnp-3500	178	4	elevated	elevated	ADJ
fnp-3500	178	5	creatine	creatine	NOUN
fnp-3500	178	6	kinase	kinase	PROPN
fnp-3500	178	7	and	and	CCONJ
fnp-3500	178	8	cardiac	cardiac	ADJ
fnp-3500	178	9	involvement	involvement	NOUN
fnp-3500	178	10	are	be	AUX
fnp-3500	178	11	present	present	ADJ
fnp-3500	178	12	in	in	ADP
fnp-3500	178	13	all	all	DET
fnp-3500	178	14	patients	patient	NOUN
fnp-3500	178	15	.	.	PUNCT
fnp-3500	179	1	muscle	muscle	NOUN
fnp-3500	179	2	weakness	weakness	NOUN
fnp-3500	179	3	was	be	AUX
fnp-3500	179	4	not	not	PART
fnp-3500	179	5	present	present	ADJ
fnp-3500	179	6	in	in	ADP
fnp-3500	179	7	any	any	PRON
fnp-3500	179	8	of	of	ADP
fnp-3500	179	9	the	the	DET
fnp-3500	179	10	patients	patient	NOUN
fnp-3500	179	11	,	,	PUNCT
fnp-3500	179	12	considering	consider	VERB
fnp-3500	179	13	the	the	DET
fnp-3500	179	14	oldest	old	ADJ
fnp-3500	179	15	being	be	AUX
fnp-3500	179	16	19	19	NUM
fnp-3500	179	17	years	year	NOUN
fnp-3500	179	18	old	old	ADJ
fnp-3500	179	19	.	.	PUNCT
fnp-3500	180	1	however	however	ADV
fnp-3500	180	2	,	,	PUNCT
fnp-3500	180	3	histological	histological	ADJ
fnp-3500	180	4	and	and	CCONJ
fnp-3500	180	5	ultrastructural	ultrastructural	ADJ
fnp-3500	180	6	analysis	analysis	NOUN
fnp-3500	180	7	revealed	reveal	VERB
fnp-3500	180	8	a	a	DET
fnp-3500	180	9	myopathy	myopathy	ADJ
fnp-3500	180	10	.	.	PUNCT
fnp-3500	181	1	immunohistochemistry	immunohistochemistry	NOUN
fnp-3500	181	2	showed	show	VERB
fnp-3500	181	3	an	an	DET
fnp-3500	181	4	absence	absence	NOUN
fnp-3500	181	5	of	of	ADP
fnp-3500	181	6	sarcolemnal	sarcolemnal	ADJ
fnp-3500	181	7	expression	expression	NOUN
fnp-3500	181	8	of	of	ADP
fnp-3500	181	9	bves	bve	NOUN
fnp-3500	181	10	confirming	confirm	VERB
fnp-3500	181	11	the	the	DET
fnp-3500	181	12	diagnosis	diagnosis	NOUN
fnp-3500	181	13	.	.	PUNCT
fnp-3500	182	1	additional	additional	ADJ
fnp-3500	182	2	proteomic	proteomic	ADJ
fnp-3500	182	3	analyses	analysis	NOUN
fnp-3500	182	4	were	be	AUX
fnp-3500	182	5	indicative	indicative	ADJ
fnp-3500	182	6	for	for	ADP
fnp-3500	182	7	an	an	DET
fnp-3500	182	8	impairment	impairment	NOUN
fnp-3500	182	9	of	of	ADP
fnp-3500	182	10	the	the	DET
fnp-3500	182	11	calcium	calcium	NOUN
fnp-3500	182	12	balance	balance	NOUN
fnp-3500	182	13	and	and	CCONJ
fnp-3500	182	14	thus	thus	ADV
fnp-3500	182	15	a	a	DET
fnp-3500	182	16	potential	potential	ADJ
fnp-3500	182	17	influence	influence	NOUN
fnp-3500	182	18	on	on	ADP
fnp-3500	182	19	the	the	DET
fnp-3500	182	20	contractile	contractile	NOUN
fnp-3500	182	21	apparatus	apparatus	NOUN
fnp-3500	182	22	.	.	PUNCT
fnp-3500	183	1	conclusion	conclusion	NOUN
fnp-3500	183	2	:	:	PUNCT
fnp-3500	183	3	to	to	PART
fnp-3500	183	4	conclude	conclude	VERB
fnp-3500	183	5	,	,	PUNCT
fnp-3500	183	6	lgmdr25	lgmdr25	PROPN
fnp-3500	183	7	should	should	AUX
fnp-3500	183	8	be	be	AUX
fnp-3500	183	9	considered	consider	VERB
fnp-3500	183	10	in	in	ADP
fnp-3500	183	11	children	child	NOUN
fnp-3500	183	12	with	with	ADP
fnp-3500	183	13	cardiac	cardiac	ADJ
fnp-3500	183	14	symptoms	symptom	NOUN
fnp-3500	183	15	and	and	CCONJ
fnp-3500	183	16	highly	highly	ADV
fnp-3500	183	17	elevated	elevate	VERB
fnp-3500	183	18	creatine	creatine	NOUN
fnp-3500	183	19	kinase	kinase	NOUN
fnp-3500	183	20	,	,	PUNCT
fnp-3500	183	21	even	even	ADV
fnp-3500	183	22	in	in	ADP
fnp-3500	183	23	the	the	DET
fnp-3500	183	24	absence	absence	NOUN
fnp-3500	183	25	of	of	ADP
fnp-3500	183	26	muscle	muscle	NOUN
fnp-3500	183	27	weakness	weakness	NOUN
fnp-3500	183	28	.	.	PUNCT
fnp-3500	184	1	a	a	DET
fnp-3500	184	2	muscle	muscle	NOUN
fnp-3500	184	3	biopsy	biopsy	NOUN
fnp-3500	184	4	is	be	AUX
fnp-3500	184	5	helpful	helpful	ADJ
fnp-3500	184	6	to	to	PART
fnp-3500	184	7	confirm	confirm	VERB
fnp-3500	184	8	the	the	DET
fnp-3500	184	9	diagnosis	diagnosis	NOUN
fnp-3500	184	10	and	and	CCONJ
fnp-3500	184	11	to	to	PART
fnp-3500	184	12	increase	increase	VERB
fnp-3500	184	13	the	the	DET
fnp-3500	184	14	understanding	understanding	NOUN
fnp-3500	184	15	of	of	ADP
fnp-3500	184	16	the	the	DET
fnp-3500	184	17	disease	disease	NOUN
fnp-3500	184	18	pathology	pathology	NOUN
fnp-3500	184	19	.	.	PUNCT
fnp-3500	184	20	  	  	SPACE
fnp-3500	185	1	neurodegeneration	neurodegeneration	NOUN
fnp-3500	185	2	/	/	SYM
fnp-3500	185	3	covid-19	covid-19	PROPN
fnp-3500	185	4	and	and	CCONJ
fnp-3500	185	5	neuropathology	neuropathology	NOUN
fnp-3500	185	6	nd-01	nd-01	ADV
fnp-3500	185	7	free	free	ADJ
fnp-3500	185	8	neuropathol	neuropathol	NOUN
fnp-3500	185	9	2:22:23	2:22:23	NUM
fnp-3500	185	10	combining	combine	VERB
fnp-3500	185	11	postmortem	postmortem	NOUN
fnp-3500	185	12	single	single	ADJ
fnp-3500	185	13	cell	cell	NOUN
fnp-3500	185	14	analysis	analysis	NOUN
fnp-3500	185	15	with	with	ADP
fnp-3500	185	16	an	an	DET
fnp-3500	185	17	induced	induced	ADJ
fnp-3500	185	18	pluripotent	pluripotent	ADJ
fnp-3500	185	19	stem	stem	NOUN
fnp-3500	185	20	cell	cell	NOUN
fnp-3500	185	21	model	model	NOUN
fnp-3500	185	22	to	to	PART
fnp-3500	185	23	study	study	VERB
fnp-3500	185	24	dysregulated	dysregulated	ADJ
fnp-3500	185	25	pathways	pathway	NOUN
fnp-3500	185	26	in	in	ADP
fnp-3500	185	27	frontotemporal	frontotemporal	ADJ
fnp-3500	185	28	dementia	dementia	NOUN
fnp-3500	185	29	o.	o.	PROPN
fnp-3500	185	30	al	al	PROPN
fnp-3500	185	31	dalahmah1	dalahmah1	PROPN
fnp-3500	185	32	,	,	PUNCT
fnp-3500	185	33	r.	r.	PROPN
fnp-3500	185	34	kühn1	kühn1	PROPN
fnp-3500	185	35	,	,	PUNCT
fnp-3500	185	36	t.	t.	PROPN
fnp-3500	185	37	nguyen1	nguyen1	PROPN
fnp-3500	185	38	,	,	PUNCT
fnp-3500	185	39	m.	m.	NOUN
fnp-3500	185	40	deture2	deture2	PROPN
fnp-3500	185	41	,	,	PUNCT
fnp-3500	185	42	m.	m.	NOUN
fnp-3500	185	43	siegelin1	siegelin1	PROPN
fnp-3500	185	44	,	,	PUNCT
fnp-3500	185	45	d.	d.	PROPN
fnp-3500	185	46	dickson2	dickson2	PROPN
fnp-3500	185	47	,	,	PUNCT
fnp-3500	185	48	j.	j.	PROPN
fnp-3500	185	49	p.	p.	PROPN
fnp-3500	185	50	vonsattel1	vonsattel1	PROPN
fnp-3500	185	51	,	,	PUNCT
fnp-3500	185	52	j.	j.	PROPN
fnp-3500	185	53	goldman1	goldman1	PROPN
fnp-3500	185	54	,	,	PUNCT
fnp-3500	185	55	p.	p.	PROPN
fnp-3500	185	56	canoll1	canoll1	PROPN
fnp-3500	185	57	,	,	PUNCT
fnp-3500	185	58	g.	g.	PROPN
fnp-3500	185	59	hargus1	hargus1	PROPN
fnp-3500	186	1	1	1	NUM
fnp-3500	186	2	columbia	columbia	PROPN
fnp-3500	186	3	university	university	PROPN
fnp-3500	186	4	,	,	PUNCT
fnp-3500	186	5	department	department	NOUN
fnp-3500	186	6	of	of	ADP
fnp-3500	186	7	pathology	pathology	NOUN
fnp-3500	186	8	and	and	CCONJ
fnp-3500	186	9	cell	cell	NOUN
fnp-3500	186	10	biology	biology	NOUN
fnp-3500	186	11	,	,	PUNCT
fnp-3500	186	12	new	new	PROPN
fnp-3500	186	13	york	york	PROPN
fnp-3500	186	14	,	,	PUNCT
fnp-3500	186	15	ny	ny	PROPN
fnp-3500	186	16	,	,	PUNCT
fnp-3500	186	17	united	united	PROPN
fnp-3500	186	18	states	states	PROPN
fnp-3500	186	19	2	2	NUM
fnp-3500	186	20	mayo	mayo	NOUN
fnp-3500	186	21	clinic	clinic	NOUN
fnp-3500	186	22	,	,	PUNCT
fnp-3500	186	23	jacksonville	jacksonville	PROPN
fnp-3500	186	24	,	,	PUNCT
fnp-3500	186	25	fl	fl	PROPN
fnp-3500	186	26	,	,	PUNCT
fnp-3500	186	27	united	united	PROPN
fnp-3500	186	28	states	states	PROPN
fnp-3500	186	29	introduction	introduction	NOUN
fnp-3500	186	30	:	:	PUNCT
fnp-3500	186	31	frontotemporal	frontotemporal	ADJ
fnp-3500	186	32	dementia	dementia	NOUN
fnp-3500	186	33	(	(	PUNCT
fnp-3500	186	34	ftd	ftd	NOUN
fnp-3500	186	35	)	)	PUNCT
fnp-3500	186	36	is	be	AUX
fnp-3500	186	37	a	a	DET
fnp-3500	186	38	group	group	NOUN
fnp-3500	186	39	of	of	ADP
fnp-3500	186	40	early	early	ADJ
fnp-3500	186	41	-	-	PUNCT
fnp-3500	186	42	onset	onset	NOUN
fnp-3500	186	43	dementias	dementia	NOUN
fnp-3500	186	44	leading	lead	VERB
fnp-3500	186	45	to	to	ADP
fnp-3500	186	46	an	an	DET
fnp-3500	186	47	impairment	impairment	NOUN
fnp-3500	186	48	of	of	ADP
fnp-3500	186	49	behavior	behavior	NOUN
fnp-3500	186	50	,	,	PUNCT
fnp-3500	186	51	language	language	NOUN
fnp-3500	186	52	and	and	CCONJ
fnp-3500	186	53	cognition	cognition	NOUN
fnp-3500	186	54	.	.	PUNCT
fnp-3500	187	1	ftd	ftd	PROPN
fnp-3500	187	2	can	can	AUX
fnp-3500	187	3	be	be	AUX
fnp-3500	187	4	caused	cause	VERB
fnp-3500	187	5	by	by	ADP
fnp-3500	187	6	mutations	mutation	NOUN
fnp-3500	187	7	in	in	ADP
fnp-3500	187	8	the	the	DET
fnp-3500	187	9	mapt	mapt	NOUN
fnp-3500	187	10	gene	gene	NOUN
fnp-3500	187	11	encoding	encode	VERB
fnp-3500	187	12	the	the	DET
fnp-3500	187	13	microtubule	microtubule	NOUN
fnp-3500	187	14	-	-	PUNCT
fnp-3500	187	15	associated	associate	VERB
fnp-3500	187	16	protein	protein	NOUN
fnp-3500	187	17	tau	tau	PROPN
fnp-3500	187	18	resulting	result	VERB
fnp-3500	187	19	in	in	ADP
fnp-3500	187	20	pronounced	pronounce	VERB
fnp-3500	187	21	atrophy	atrophy	NOUN
fnp-3500	187	22	of	of	ADP
fnp-3500	187	23	the	the	DET
fnp-3500	187	24	frontal	frontal	ADJ
fnp-3500	187	25	and	and	CCONJ
fnp-3500	187	26	temporal	temporal	ADJ
fnp-3500	187	27	lobes	lobe	NOUN
fnp-3500	187	28	,	,	PUNCT
fnp-3500	187	29	basal	basal	ADJ
fnp-3500	187	30	ganglia	ganglia	NOUN
fnp-3500	187	31	and	and	CCONJ
fnp-3500	187	32	brain	brain	NOUN
fnp-3500	187	33	stem	stem	NOUN
fnp-3500	187	34	areas	area	NOUN
fnp-3500	187	35	.	.	PUNCT
fnp-3500	188	1	objectives	objective	NOUN
fnp-3500	188	2	:	:	PUNCT
fnp-3500	188	3	currently	currently	ADV
fnp-3500	188	4	,	,	PUNCT
fnp-3500	188	5	the	the	DET
fnp-3500	188	6	underlying	underlying	ADJ
fnp-3500	188	7	mechanisms	mechanism	NOUN
fnp-3500	188	8	of	of	ADP
fnp-3500	188	9	neurodegeneration	neurodegeneration	NOUN
fnp-3500	188	10	are	be	AUX
fnp-3500	188	11	not	not	PART
fnp-3500	188	12	clearly	clearly	ADV
fnp-3500	188	13	understood	understand	VERB
fnp-3500	188	14	and	and	CCONJ
fnp-3500	188	15	curative	curative	ADJ
fnp-3500	188	16	options	option	NOUN
fnp-3500	188	17	do	do	AUX
fnp-3500	188	18	not	not	PART
fnp-3500	188	19	exit	exit	VERB
fnp-3500	188	20	.	.	PUNCT
fnp-3500	189	1	materials	material	NOUN
fnp-3500	189	2	&	&	CCONJ
fnp-3500	189	3	methods	method	NOUN
fnp-3500	189	4	:	:	PUNCT
fnp-3500	189	5	here	here	ADV
fnp-3500	189	6	,	,	PUNCT
fnp-3500	189	7	we	we	PRON
fnp-3500	189	8	performed	perform	VERB
fnp-3500	189	9	single	single	ADJ
fnp-3500	189	10	nucleus	nucleus	PROPN
fnp-3500	189	11	rna	rna	NOUN
fnp-3500	189	12	sequencing	sequence	VERB
fnp-3500	189	13	(	(	PUNCT
fnp-3500	189	14	snrna	snrna	ADJ
fnp-3500	189	15	-	-	PUNCT
fnp-3500	189	16	seq	seq	NOUN
fnp-3500	189	17	)	)	PUNCT
fnp-3500	189	18	on	on	ADP
fnp-3500	189	19	postmortem	postmortem	NOUN
fnp-3500	189	20	brain	brain	NOUN
fnp-3500	189	21	tissue	tissue	NOUN
fnp-3500	189	22	from	from	ADP
fnp-3500	189	23	ftd	ftd	PROPN
fnp-3500	189	24	patients	patient	NOUN
fnp-3500	189	25	carrying	carry	VERB
fnp-3500	189	26	the	the	DET
fnp-3500	189	27	maptn279k	maptn279k	NOUN
fnp-3500	189	28	mutation	mutation	NOUN
fnp-3500	189	29	and	and	CCONJ
fnp-3500	189	30	from	from	ADP
fnp-3500	189	31	healthy	healthy	ADJ
fnp-3500	189	32	control	control	NOUN
fnp-3500	189	33	individuals	individual	NOUN
fnp-3500	189	34	to	to	PART
fnp-3500	189	35	identify	identify	VERB
fnp-3500	189	36	dysregulated	dysregulated	ADJ
fnp-3500	189	37	pathways	pathway	NOUN
fnp-3500	189	38	in	in	ADP
fnp-3500	189	39	patient	patient	ADJ
fnp-3500	189	40	cells	cell	NOUN
fnp-3500	189	41	at	at	ADP
fnp-3500	189	42	single	single	ADJ
fnp-3500	189	43	cell	cell	NOUN
fnp-3500	189	44	resolution	resolution	NOUN
fnp-3500	189	45	.	.	PUNCT
fnp-3500	190	1	results	result	NOUN
fnp-3500	190	2	:	:	PUNCT
fnp-3500	190	3	we	we	PRON
fnp-3500	190	4	found	find	VERB
fnp-3500	190	5	significant	significant	ADJ
fnp-3500	190	6	changes	change	NOUN
fnp-3500	190	7	in	in	ADP
fnp-3500	190	8	pathways	pathway	NOUN
fnp-3500	190	9	related	relate	VERB
fnp-3500	190	10	to	to	ADP
fnp-3500	190	11	cell	cell	NOUN
fnp-3500	190	12	metabolism	metabolism	NOUN
fnp-3500	190	13	and	and	CCONJ
fnp-3500	190	14	neuroinflammation	neuroinflammation	NOUN
fnp-3500	190	15	in	in	ADP
fnp-3500	190	16	patient	patient	ADJ
fnp-3500	190	17	neurons	neuron	NOUN
fnp-3500	190	18	that	that	PRON
fnp-3500	190	19	we	we	PRON
fnp-3500	190	20	tested	test	VERB
fnp-3500	190	21	further	far	ADV
fnp-3500	190	22	in	in	ADP
fnp-3500	190	23	a	a	DET
fnp-3500	190	24	stem	stem	NOUN
fnp-3500	190	25	cell	cell	NOUN
fnp-3500	190	26	model	model	NOUN
fnp-3500	190	27	of	of	ADP
fnp-3500	190	28	ftd	ftd	PROPN
fnp-3500	190	29	using	use	VERB
fnp-3500	190	30	patientand	patientand	PROPN
fnp-3500	190	31	control	control	PROPN
fnp-3500	190	32	individual	individual	ADJ
fnp-3500	190	33	-	-	PUNCT
fnp-3500	190	34	derived	derive	VERB
fnp-3500	190	35	induced	induce	VERB
fnp-3500	190	36	pluripotent	pluripotent	ADJ
fnp-3500	190	37	stem	stem	NOUN
fnp-3500	190	38	cells	cell	NOUN
fnp-3500	190	39	(	(	PUNCT
fnp-3500	190	40	ipscs	ipscs	NOUN
fnp-3500	190	41	)	)	PUNCT
fnp-3500	190	42	.	.	PUNCT
fnp-3500	191	1	patient	patient	PROPN
fnp-3500	191	2	ipsc	ipsc	NOUN
fnp-3500	191	3	-	-	PUNCT
fnp-3500	191	4	derived	derive	VERB
fnp-3500	191	5	neurons	neuron	NOUN
fnp-3500	191	6	with	with	ADP
fnp-3500	191	7	the	the	DET
fnp-3500	191	8	maptn279k	maptn279k	PROPN
fnp-3500	191	9	mutation	mutation	NOUN
fnp-3500	191	10	demonstrated	demonstrate	VERB
fnp-3500	191	11	tau	tau	PROPN
fnp-3500	191	12	pathology	pathology	NOUN
fnp-3500	191	13	,	,	PUNCT
fnp-3500	191	14	an	an	DET
fnp-3500	191	15	impairment	impairment	NOUN
fnp-3500	191	16	of	of	ADP
fnp-3500	191	17	neurite	neurite	ADJ
fnp-3500	191	18	outgrowth	outgrowth	NOUN
fnp-3500	191	19	and	and	CCONJ
fnp-3500	191	20	an	an	DET
fnp-3500	191	21	increased	increased	ADJ
fnp-3500	191	22	but	but	CCONJ
fnp-3500	191	23	reversible	reversible	ADJ
fnp-3500	191	24	oxidative	oxidative	ADJ
fnp-3500	191	25	stress	stress	NOUN
fnp-3500	191	26	response	response	NOUN
fnp-3500	191	27	.	.	PUNCT
fnp-3500	192	1	ftd	ftd	PROPN
fnp-3500	192	2	neurons	neuron	NOUN
fnp-3500	192	3	also	also	ADV
fnp-3500	192	4	showed	show	VERB
fnp-3500	192	5	altered	alter	VERB
fnp-3500	192	6	metabolic	metabolic	NOUN
fnp-3500	192	7	profiles	profile	NOUN
fnp-3500	192	8	with	with	ADP
fnp-3500	192	9	an	an	DET
fnp-3500	192	10	increased	increase	VERB
fnp-3500	192	11	basal	basal	ADJ
fnp-3500	192	12	mitochondrial	mitochondrial	ADJ
fnp-3500	192	13	respiration	respiration	NOUN
fnp-3500	192	14	and	and	CCONJ
fnp-3500	192	15	increased	increase	VERB
fnp-3500	192	16	atp	atp	NOUN
fnp-3500	192	17	production	production	NOUN
fnp-3500	192	18	indicating	indicate	VERB
fnp-3500	192	19	an	an	DET
fnp-3500	192	20	increased	increase	VERB
fnp-3500	192	21	energy	energy	NOUN
fnp-3500	192	22	demand	demand	NOUN
fnp-3500	192	23	in	in	ADP
fnp-3500	192	24	these	these	DET
fnp-3500	192	25	cells	cell	NOUN
fnp-3500	192	26	.	.	PUNCT
fnp-3500	193	1	interestingly	interestingly	ADV
fnp-3500	193	2	,	,	PUNCT
fnp-3500	193	3	ftd	ftd	PROPN
fnp-3500	193	4	neurons	neuron	NOUN
fnp-3500	193	5	also	also	ADV
fnp-3500	193	6	had	have	VERB
fnp-3500	193	7	a	a	DET
fnp-3500	193	8	significant	significant	ADJ
fnp-3500	193	9	effect	effect	NOUN
fnp-3500	193	10	on	on	ADP
fnp-3500	193	11	the	the	DET
fnp-3500	193	12	survival	survival	NOUN
fnp-3500	193	13	of	of	ADP
fnp-3500	193	14	host	host	NOUN
fnp-3500	193	15	neurons	neuron	NOUN
fnp-3500	193	16	and	and	CCONJ
fnp-3500	193	17	on	on	ADP
fnp-3500	193	18	glial	glial	ADJ
fnp-3500	193	19	cell	cell	NOUN
fnp-3500	193	20	responses	response	NOUN
fnp-3500	193	21	when	when	SCONJ
fnp-3500	193	22	transplanted	transplant	VERB
fnp-3500	193	23	into	into	ADP
fnp-3500	193	24	the	the	DET
fnp-3500	193	25	brains	brain	NOUN
fnp-3500	193	26	of	of	ADP
fnp-3500	193	27	immunocompromised	immunocompromise	VERB
fnp-3500	193	28	mice	mouse	NOUN
fnp-3500	193	29	indicating	indicate	VERB
fnp-3500	193	30	a	a	DET
fnp-3500	193	31	potential	potential	ADJ
fnp-3500	193	32	immunomodulatory	immunomodulatory	ADJ
fnp-3500	193	33	role	role	NOUN
fnp-3500	193	34	of	of	ADP
fnp-3500	193	35	patient	patient	ADJ
fnp-3500	193	36	neurons	neuron	NOUN
fnp-3500	193	37	in	in	ADP
fnp-3500	193	38	vivo	vivo	NOUN
fnp-3500	193	39	.	.	PUNCT
fnp-3500	194	1	conclusion	conclusion	NOUN
fnp-3500	194	2	:	:	PUNCT
fnp-3500	194	3	these	these	DET
fnp-3500	194	4	findings	finding	NOUN
fnp-3500	194	5	demonstrate	demonstrate	VERB
fnp-3500	194	6	that	that	SCONJ
fnp-3500	194	7	a	a	DET
fnp-3500	194	8	combinatorial	combinatorial	ADJ
fnp-3500	194	9	approach	approach	NOUN
fnp-3500	194	10	applying	apply	VERB
fnp-3500	194	11	snrna	snrna	NOUN
fnp-3500	194	12	-	-	PUNCT
fnp-3500	194	13	seq	seq	NOUN
fnp-3500	194	14	on	on	ADP
fnp-3500	194	15	patient	patient	ADJ
fnp-3500	194	16	brain	brain	NOUN
fnp-3500	194	17	tissue	tissue	NOUN
fnp-3500	194	18	and	and	CCONJ
fnp-3500	194	19	a	a	DET
fnp-3500	194	20	dynamic	dynamic	ADJ
fnp-3500	194	21	ipsc	ipsc	NOUN
fnp-3500	194	22	model	model	NOUN
fnp-3500	194	23	comprises	comprise	VERB
fnp-3500	194	24	a	a	DET
fnp-3500	194	25	powerful	powerful	ADJ
fnp-3500	194	26	tool	tool	NOUN
fnp-3500	194	27	to	to	PART
fnp-3500	194	28	identify	identify	VERB
fnp-3500	194	29	disease	disease	NOUN
fnp-3500	194	30	phenotypes	phenotype	NOUN
fnp-3500	194	31	in	in	ADP
fnp-3500	194	32	neural	neural	ADJ
fnp-3500	194	33	cells	cell	NOUN
fnp-3500	194	34	at	at	ADP
fnp-3500	194	35	risk	risk	NOUN
fnp-3500	194	36	in	in	ADP
fnp-3500	194	37	ftd	ftd	PROPN
fnp-3500	194	38	.	.	PUNCT
fnp-3500	195	1	such	such	ADJ
fnp-3500	195	2	stem	stem	NOUN
fnp-3500	195	3	cell	cell	NOUN
fnp-3500	195	4	model	model	NOUN
fnp-3500	195	5	could	could	AUX
fnp-3500	195	6	also	also	ADV
fnp-3500	195	7	be	be	AUX
fnp-3500	195	8	used	use	VERB
fnp-3500	195	9	as	as	ADP
fnp-3500	195	10	a	a	DET
fnp-3500	195	11	cellular	cellular	ADJ
fnp-3500	195	12	platform	platform	NOUN
fnp-3500	195	13	for	for	ADP
fnp-3500	195	14	high	high	ADJ
fnp-3500	195	15	-	-	PUNCT
fnp-3500	195	16	throughput	throughput	NOUN
fnp-3500	195	17	drug	drug	NOUN
fnp-3500	195	18	screening	screen	VERB
fnp-3500	195	19	assays	assay	NOUN
fnp-3500	195	20	to	to	PART
fnp-3500	195	21	identify	identify	VERB
fnp-3500	195	22	potential	potential	ADJ
fnp-3500	195	23	therapeutic	therapeutic	ADJ
fnp-3500	195	24	targets	target	NOUN
fnp-3500	195	25	in	in	ADP
fnp-3500	195	26	ftd	ftd	PROPN
fnp-3500	195	27	.	.	PUNCT
fnp-3500	195	28	  	  	SPACE
fnp-3500	196	1	nd-02	nd-02	CCONJ
fnp-3500	196	2	free	free	ADJ
fnp-3500	196	3	neuropathol	neuropathol	NOUN
fnp-3500	196	4	2:22:24	2:22:24	NUM
fnp-3500	196	5	deep	deep	ADJ
fnp-3500	196	6	learning	learning	NOUN
fnp-3500	196	7	assisted	assist	VERB
fnp-3500	196	8	quantitative	quantitative	ADJ
fnp-3500	196	9	assessment	assessment	NOUN
fnp-3500	196	10	of	of	ADP
fnp-3500	196	11	histopathological	histopathological	ADJ
fnp-3500	196	12	markers	marker	NOUN
fnp-3500	196	13	of	of	ADP
fnp-3500	196	14	alzheimer"s	alzheimer"s	PROPN
fnp-3500	196	15	disease	disease	NOUN
fnp-3500	196	16	and	and	CCONJ
fnp-3500	196	17	cerebral	cerebral	ADJ
fnp-3500	196	18	amyloid	amyloid	NOUN
fnp-3500	196	19	angiopathy	angiopathy	NOUN
fnp-3500	196	20	v.	v.	ADP
fnp-3500	196	21	perosa1,2	perosa1,2	PROPN
fnp-3500	196	22	,	,	PUNCT
fnp-3500	196	23	a.	a.	PROPN
fnp-3500	196	24	scherleck3	scherleck3	PROPN
fnp-3500	196	25	,	,	PUNCT
fnp-3500	196	26	m.	m.	PROPN
fnp-3500	196	27	kozberg1	kozberg1	PROPN
fnp-3500	196	28	,	,	PUNCT
fnp-3500	196	29	l.	l.	PROPN
fnp-3500	196	30	smith4	smith4	PROPN
fnp-3500	196	31	,	,	PUNCT
fnp-3500	196	32	t.	t.	NOUN
fnp-3500	196	33	westerling	westerling	NOUN
fnp-3500	196	34	-	-	PUNCT
fnp-3500	196	35	bui4	bui4	NOUN
fnp-3500	196	36	,	,	PUNCT
fnp-3500	196	37	c.	c.	PROPN
fnp-3500	196	38	a.	a.	PROPN
fnp-3500	196	39	auger5	auger5	PROPN
fnp-3500	196	40	,	,	PUNCT
fnp-3500	196	41	s.	s.	PROPN
fnp-3500	196	42	vasylechko6	vasylechko6	PROPN
fnp-3500	196	43	,	,	PUNCT
fnp-3500	196	44	s.	s.	PROPN
fnp-3500	196	45	m.	m.	PROPN
fnp-3500	196	46	greenberg1	greenberg1	PROPN
fnp-3500	196	47	,	,	PUNCT
fnp-3500	196	48	s.	s.	PROPN
fnp-3500	196	49	j.	j.	PROPN
fnp-3500	196	50	van	van	PROPN
fnp-3500	196	51	veluw1,5	veluw1,5	PROPN
fnp-3500	196	52	1	1	NUM
fnp-3500	196	53	massachusetts	massachusetts	PROPN
fnp-3500	196	54	general	general	ADJ
fnp-3500	196	55	hospital	hospital	NOUN
fnp-3500	196	56	,	,	PUNCT
fnp-3500	196	57	1j	1j	NUM
fnp-3500	196	58	.	.	PUNCT
fnp-3500	197	1	philip	philip	PROPN
fnp-3500	197	2	kistler	kistler	PROPN
fnp-3500	197	3	stroke	stroke	PROPN
fnp-3500	197	4	research	research	PROPN
fnp-3500	197	5	center	center	PROPN
fnp-3500	197	6	,	,	PUNCT
fnp-3500	197	7	boston	boston	PROPN
fnp-3500	197	8	,	,	PUNCT
fnp-3500	197	9	ma	ma	PROPN
fnp-3500	197	10	,	,	PUNCT
fnp-3500	197	11	united	united	PROPN
fnp-3500	197	12	states	states	PROPN
fnp-3500	197	13	2	2	NUM
fnp-3500	197	14	otto	otto	PROPN
fnp-3500	197	15	-	-	PUNCT
fnp-3500	197	16	von	von	PROPN
fnp-3500	197	17	-	-	PUNCT
fnp-3500	197	18	guericke	guericke	PROPN
fnp-3500	197	19	university	university	PROPN
fnp-3500	197	20	,	,	PUNCT
fnp-3500	197	21	department	department	NOUN
fnp-3500	197	22	of	of	ADP
fnp-3500	197	23	neurology	neurology	NOUN
fnp-3500	197	24	,	,	PUNCT
fnp-3500	197	25	magdeburg	magdeburg	PROPN
fnp-3500	197	26	,	,	PUNCT
fnp-3500	197	27	germany	germany	PROPN
fnp-3500	197	28	3	3	NUM
fnp-3500	197	29	rush	rush	PROPN
fnp-3500	197	30	university	university	PROPN
fnp-3500	197	31	medical	medical	ADJ
fnp-3500	197	32	center	center	NOUN
fnp-3500	197	33	,	,	PUNCT
fnp-3500	197	34	3rush	3rush	NUM
fnp-3500	197	35	alzheimer	alzheimer	NOUN
fnp-3500	197	36	disease	disease	NOUN
fnp-3500	197	37	center	center	NOUN
fnp-3500	197	38	,	,	PUNCT
fnp-3500	197	39	chicago	chicago	PROPN
fnp-3500	197	40	,	,	PUNCT
fnp-3500	197	41	il	il	PROPN
fnp-3500	197	42	,	,	PUNCT
fnp-3500	197	43	united	united	PROPN
fnp-3500	197	44	states	states	PROPN
fnp-3500	197	45	4	4	NUM
fnp-3500	197	46	aiforia	aiforia	PROPN
fnp-3500	197	47	inc	inc	PROPN
fnp-3500	197	48	,	,	PUNCT
fnp-3500	197	49	cambridge	cambridge	PROPN
fnp-3500	197	50	,	,	PUNCT
fnp-3500	197	51	ma	ma	PROPN
fnp-3500	197	52	,	,	PUNCT
fnp-3500	197	53	united	united	PROPN
fnp-3500	197	54	states	states	PROPN
fnp-3500	197	55	5	5	NUM
fnp-3500	197	56	massachusetts	massachusetts	PROPN
fnp-3500	197	57	general	general	ADJ
fnp-3500	197	58	hospital	hospital	NOUN
fnp-3500	197	59	,	,	PUNCT
fnp-3500	197	60	massgeneral	massgeneral	PROPN
fnp-3500	197	61	institute	institute	NOUN
fnp-3500	197	62	for	for	ADP
fnp-3500	197	63	neurodegenerative	neurodegenerative	ADJ
fnp-3500	197	64	disease	disease	NOUN
fnp-3500	197	65	,	,	PUNCT
fnp-3500	197	66	charlestown	charlestown	PROPN
fnp-3500	197	67	,	,	PUNCT
fnp-3500	197	68	ma	ma	PROPN
fnp-3500	197	69	,	,	PUNCT
fnp-3500	197	70	united	united	PROPN
fnp-3500	197	71	states	states	PROPN
fnp-3500	197	72	6	6	NUM
fnp-3500	197	73	boston	boston	PROPN
fnp-3500	197	74	children	child	NOUN
fnp-3500	197	75	's	's	PART
fnp-3500	197	76	hospital	hospital	NOUN
fnp-3500	197	77	,	,	PUNCT
fnp-3500	197	78	computational	computational	ADJ
fnp-3500	197	79	radiology	radiology	NOUN
fnp-3500	197	80	laboratory	laboratory	NOUN
fnp-3500	197	81	,	,	PUNCT
fnp-3500	197	82	boston	boston	PROPN
fnp-3500	197	83	,	,	PUNCT
fnp-3500	197	84	ma	ma	PROPN
fnp-3500	197	85	,	,	PUNCT
fnp-3500	197	86	united	united	PROPN
fnp-3500	197	87	states	states	PROPN
fnp-3500	197	88	introduction	introduction	NOUN
fnp-3500	197	89	:	:	PUNCT
fnp-3500	197	90	traditionally	traditionally	ADV
fnp-3500	197	91	,	,	PUNCT
fnp-3500	197	92	analysis	analysis	NOUN
fnp-3500	197	93	of	of	ADP
fnp-3500	197	94	neuropathological	neuropathological	ADJ
fnp-3500	197	95	markers	marker	NOUN
fnp-3500	197	96	in	in	ADP
fnp-3500	197	97	neurodegenerative	neurodegenerative	ADJ
fnp-3500	197	98	diseases	disease	NOUN
fnp-3500	197	99	has	have	AUX
fnp-3500	197	100	relied	rely	VERB
fnp-3500	197	101	on	on	ADP
fnp-3500	197	102	visual	visual	ADJ
fnp-3500	197	103	assessments	assessment	NOUN
fnp-3500	197	104	of	of	ADP
fnp-3500	197	105	stained	stain	VERB
fnp-3500	197	106	sections	section	NOUN
fnp-3500	197	107	.	.	PUNCT
fnp-3500	198	1	resulting	result	VERB
fnp-3500	198	2	semiquantitative	semiquantitative	ADJ
fnp-3500	198	3	scores	score	NOUN
fnp-3500	198	4	often	often	ADV
fnp-3500	198	5	vary	vary	VERB
fnp-3500	198	6	between	between	ADP
fnp-3500	198	7	individual	individual	ADJ
fnp-3500	198	8	raters	rater	NOUN
fnp-3500	198	9	and	and	CCONJ
fnp-3500	198	10	research	research	NOUN
fnp-3500	198	11	centers	center	NOUN
fnp-3500	198	12	,	,	PUNCT
fnp-3500	198	13	limiting	limit	VERB
fnp-3500	198	14	statistical	statistical	ADJ
fnp-3500	198	15	approaches	approach	NOUN
fnp-3500	198	16	.	.	PUNCT
fnp-3500	199	1	to	to	PART
fnp-3500	199	2	overcome	overcome	VERB
fnp-3500	199	3	these	these	DET
fnp-3500	199	4	issues	issue	NOUN
fnp-3500	199	5	,	,	PUNCT
fnp-3500	199	6	we	we	PRON
fnp-3500	199	7	have	have	AUX
fnp-3500	199	8	developed	develop	VERB
fnp-3500	199	9	six	six	NUM
fnp-3500	199	10	deep	deep	ADJ
fnp-3500	199	11	learning	learning	NOUN
fnp-3500	199	12	-	-	PUNCT
fnp-3500	199	13	based	base	VERB
fnp-3500	199	14	models	model	NOUN
fnp-3500	199	15	,	,	PUNCT
fnp-3500	199	16	that	that	PRON
fnp-3500	199	17	identify	identify	VERB
fnp-3500	199	18	some	some	PRON
fnp-3500	199	19	of	of	ADP
fnp-3500	199	20	the	the	DET
fnp-3500	199	21	most	most	ADV
fnp-3500	199	22	characteristic	characteristic	ADJ
fnp-3500	199	23	markers	marker	NOUN
fnp-3500	199	24	of	of	ADP
fnp-3500	199	25	alzheimer"s	alzheimer"s	PROPN
fnp-3500	199	26	disease	disease	NOUN
fnp-3500	199	27	(	(	PUNCT
fnp-3500	199	28	ad	ad	NOUN
fnp-3500	199	29	)	)	PUNCT
fnp-3500	199	30	and	and	CCONJ
fnp-3500	199	31	cerebral	cerebral	ADJ
fnp-3500	199	32	amyloid	amyloid	NOUN
fnp-3500	199	33	angiopathy	angiopathy	ADJ
fnp-3500	199	34	(	(	PUNCT
fnp-3500	199	35	caa	caa	NOUN
fnp-3500	199	36	)	)	PUNCT
fnp-3500	199	37	.	.	PUNCT
fnp-3500	200	1	methods	method	NOUN
fnp-3500	200	2	:	:	PUNCT
fnp-3500	200	3	deep	deep	ADJ
fnp-3500	200	4	learning	learning	NOUN
fnp-3500	200	5	-	-	PUNCT
fnp-3500	200	6	based	base	VERB
fnp-3500	200	7	models	model	NOUN
fnp-3500	200	8	were	be	AUX
fnp-3500	200	9	trained	train	VERB
fnp-3500	200	10	to	to	PART
fnp-3500	200	11	differentially	differentially	ADV
fnp-3500	200	12	detect	detect	VERB
fnp-3500	200	13	parenchymal	parenchymal	ADJ
fnp-3500	200	14	amyloid	amyloid	NOUN
fnp-3500	200	15	β	β	X
fnp-3500	200	16	(	(	PUNCT
fnp-3500	200	17	aβ)-plaques	aβ)-plaque	NOUN
fnp-3500	200	18	,	,	PUNCT
fnp-3500	200	19	vascular	vascular	ADJ
fnp-3500	200	20	aβ	aβ	NOUN
fnp-3500	200	21	-	-	PUNCT
fnp-3500	200	22	deposition	deposition	NOUN
fnp-3500	200	23	,	,	PUNCT
fnp-3500	200	24	iron	iron	NOUN
fnp-3500	200	25	and	and	CCONJ
fnp-3500	200	26	calcium	calcium	NOUN
fnp-3500	200	27	deposition	deposition	NOUN
fnp-3500	200	28	,	,	PUNCT
fnp-3500	200	29	reactive	reactive	ADJ
fnp-3500	200	30	astrocytes	astrocyte	NOUN
fnp-3500	200	31	,	,	PUNCT
fnp-3500	200	32	microglia	microglia	NOUN
fnp-3500	200	33	,	,	PUNCT
fnp-3500	200	34	as	as	ADV
fnp-3500	200	35	well	well	ADV
fnp-3500	200	36	as	as	ADP
fnp-3500	200	37	fibrin	fibrin	NOUN
fnp-3500	200	38	extravasation	extravasation	NOUN
fnp-3500	200	39	.	.	PUNCT
fnp-3500	201	1	the	the	DET
fnp-3500	201	2	models	model	NOUN
fnp-3500	201	3	were	be	AUX
fnp-3500	201	4	trained	train	VERB
fnp-3500	201	5	on	on	ADP
fnp-3500	201	6	digitized	digitize	VERB
fnp-3500	201	7	histopathological	histopathological	ADJ
fnp-3500	201	8	slides	slide	NOUN
fnp-3500	201	9	from	from	ADP
fnp-3500	201	10	brains	brain	NOUN
fnp-3500	201	11	of	of	ADP
fnp-3500	201	12	patients	patient	NOUN
fnp-3500	201	13	with	with	ADP
fnp-3500	201	14	ad	ad	NOUN
fnp-3500	201	15	and	and	CCONJ
fnp-3500	201	16	caa	caa	NOUN
fnp-3500	201	17	,	,	PUNCT
fnp-3500	201	18	using	use	VERB
fnp-3500	201	19	a	a	DET
fnp-3500	201	20	workflow	workflow	NOUN
fnp-3500	201	21	that	that	PRON
fnp-3500	201	22	allows	allow	VERB
fnp-3500	201	23	neuropathology	neuropathology	NOUN
fnp-3500	201	24	experts	expert	NOUN
fnp-3500	201	25	to	to	PART
fnp-3500	201	26	train	train	VERB
fnp-3500	201	27	convolutional	convolutional	ADJ
fnp-3500	201	28	neural	neural	ADJ
fnp-3500	201	29	networks	network	NOUN
fnp-3500	201	30	(	(	PUNCT
fnp-3500	201	31	cnns	cnns	PROPN
fnp-3500	201	32	)	)	PUNCT
fnp-3500	201	33	on	on	ADP
fnp-3500	201	34	a	a	DET
fnp-3500	201	35	cloud	cloud	NOUN
fnp-3500	201	36	-	-	PUNCT
fnp-3500	201	37	based	base	VERB
fnp-3500	201	38	graphical	graphical	ADJ
fnp-3500	201	39	interface	interface	NOUN
fnp-3500	201	40	.	.	PUNCT
fnp-3500	202	1	results	result	NOUN
fnp-3500	202	2	:	:	PUNCT
fnp-3500	202	3	validation	validation	NOUN
fnp-3500	202	4	of	of	ADP
fnp-3500	202	5	all	all	DET
fnp-3500	202	6	models	model	NOUN
fnp-3500	202	7	indicated	indicate	VERB
fnp-3500	202	8	a	a	DET
fnp-3500	202	9	very	very	ADV
fnp-3500	202	10	good	good	ADJ
fnp-3500	202	11	to	to	ADP
fnp-3500	202	12	excellent	excellent	ADJ
fnp-3500	202	13	performance	performance	NOUN
fnp-3500	202	14	compared	compare	VERB
fnp-3500	202	15	to	to	ADP
fnp-3500	202	16	three	three	NUM
fnp-3500	202	17	independent	independent	ADJ
fnp-3500	202	18	expert	expert	ADJ
fnp-3500	202	19	human	human	ADJ
fnp-3500	202	20	raters	rater	NOUN
fnp-3500	202	21	.	.	PUNCT
fnp-3500	203	1	furthermore	furthermore	ADV
fnp-3500	203	2	,	,	PUNCT
fnp-3500	203	3	the	the	DET
fnp-3500	203	4	aβ	aβ	NOUN
fnp-3500	203	5	and	and	CCONJ
fnp-3500	203	6	iron	iron	NOUN
fnp-3500	203	7	models	model	NOUN
fnp-3500	203	8	were	be	AUX
fnp-3500	203	9	consistent	consistent	ADJ
fnp-3500	203	10	with	with	ADP
fnp-3500	203	11	previously	previously	ADV
fnp-3500	203	12	acquired	acquire	VERB
fnp-3500	203	13	semiquantitative	semiquantitative	ADJ
fnp-3500	203	14	scores	score	NOUN
fnp-3500	203	15	in	in	ADP
fnp-3500	203	16	the	the	DET
fnp-3500	203	17	same	same	ADJ
fnp-3500	203	18	dataset	dataset	NOUN
fnp-3500	203	19	and	and	CCONJ
fnp-3500	203	20	allowed	allow	VERB
fnp-3500	203	21	the	the	DET
fnp-3500	203	22	use	use	NOUN
fnp-3500	203	23	of	of	ADP
fnp-3500	203	24	more	more	ADV
fnp-3500	203	25	complex	complex	ADJ
fnp-3500	203	26	statistical	statistical	ADJ
fnp-3500	203	27	approaches	approach	NOUN
fnp-3500	203	28	.	.	PUNCT
fnp-3500	204	1	discussion	discussion	NOUN
fnp-3500	204	2	:	:	PUNCT
fnp-3500	204	3	the	the	DET
fnp-3500	204	4	presented	present	VERB
fnp-3500	204	5	workflow	workflow	NOUN
fnp-3500	204	6	is	be	AUX
fnp-3500	204	7	easy	easy	ADJ
fnp-3500	204	8	for	for	SCONJ
fnp-3500	204	9	researchers	researcher	NOUN
fnp-3500	204	10	with	with	ADP
fnp-3500	204	11	pathological	pathological	ADJ
fnp-3500	204	12	expertise	expertise	NOUN
fnp-3500	204	13	to	to	PART
fnp-3500	204	14	implement	implement	VERB
fnp-3500	204	15	and	and	CCONJ
fnp-3500	204	16	is	be	AUX
fnp-3500	204	17	customizable	customizable	ADJ
fnp-3500	204	18	for	for	ADP
fnp-3500	204	19	additional	additional	ADJ
fnp-3500	204	20	histopathological	histopathological	ADJ
fnp-3500	204	21	markers	marker	NOUN
fnp-3500	204	22	.	.	PUNCT
fnp-3500	205	1	the	the	DET
fnp-3500	205	2	implementation	implementation	NOUN
fnp-3500	205	3	of	of	ADP
fnp-3500	205	4	deep	deep	ADJ
fnp-3500	205	5	learning	learning	NOUN
fnp-3500	205	6	-	-	PUNCT
fnp-3500	205	7	assisted	assist	VERB
fnp-3500	205	8	analyses	analysis	NOUN
fnp-3500	205	9	of	of	ADP
fnp-3500	205	10	histopathological	histopathological	ADJ
fnp-3500	205	11	slides	slide	NOUN
fnp-3500	205	12	is	be	AUX
fnp-3500	205	13	likely	likely	ADJ
fnp-3500	205	14	to	to	PART
fnp-3500	205	15	promote	promote	VERB
fnp-3500	205	16	standardization	standardization	NOUN
fnp-3500	205	17	of	of	ADP
fnp-3500	205	18	the	the	DET
fnp-3500	205	19	assessment	assessment	NOUN
fnp-3500	205	20	of	of	ADP
fnp-3500	205	21	neuropathological	neuropathological	ADJ
fnp-3500	205	22	markers	marker	NOUN
fnp-3500	205	23	across	across	ADP
fnp-3500	205	24	research	research	NOUN
fnp-3500	205	25	centers	center	NOUN
fnp-3500	205	26	,	,	PUNCT
fnp-3500	205	27	which	which	PRON
fnp-3500	205	28	will	will	AUX
fnp-3500	205	29	allow	allow	VERB
fnp-3500	205	30	specific	specific	ADJ
fnp-3500	205	31	pathophysiological	pathophysiological	ADJ
fnp-3500	205	32	questions	question	NOUN
fnp-3500	205	33	in	in	ADP
fnp-3500	205	34	neurodegenerative	neurodegenerative	ADJ
fnp-3500	205	35	disease	disease	NOUN
fnp-3500	205	36	to	to	PART
fnp-3500	205	37	be	be	AUX
fnp-3500	205	38	addressed	address	VERB
fnp-3500	205	39	in	in	ADP
fnp-3500	205	40	a	a	DET
fnp-3500	205	41	harmonized	harmonized	ADJ
fnp-3500	205	42	way	way	NOUN
fnp-3500	205	43	and	and	CCONJ
fnp-3500	205	44	on	on	ADP
fnp-3500	205	45	a	a	DET
fnp-3500	205	46	larger	large	ADJ
fnp-3500	205	47	scale	scale	NOUN
fnp-3500	205	48	.	.	PUNCT
fnp-3500	205	49	  	  	SPACE
fnp-3500	206	1	nd-03	nd-03	X
fnp-3500	206	2	free	free	ADJ
fnp-3500	206	3	neuropathol	neuropathol	NOUN
fnp-3500	206	4	2:22:25	2:22:25	NUM
fnp-3500	206	5	exercise	exercise	NOUN
fnp-3500	206	6	ameliorates	ameliorate	VERB
fnp-3500	206	7	alzheimers	alzheimer	NOUN
fnp-3500	206	8	pathology	pathology	NOUN
fnp-3500	206	9	across	across	ADP
fnp-3500	206	10	generations	generation	NOUN
fnp-3500	206	11	a.	a.	PROPN
fnp-3500	206	12	herring1	herring1	PROPN
fnp-3500	206	13	,	,	PUNCT
fnp-3500	206	14	y.	y.	PROPN
fnp-3500	206	15	münster1	münster1	PROPN
fnp-3500	206	16	,	,	PUNCT
fnp-3500	206	17	n.	n.	PROPN
fnp-3500	206	18	kurapati1	kurapati1	PROPN
fnp-3500	206	19	,	,	PUNCT
fnp-3500	206	20	r.	r.	PROPN
fnp-3500	206	21	khadzhiev1	khadzhiev1	PROPN
fnp-3500	206	22	,	,	PUNCT
fnp-3500	206	23	k.	k.	PROPN
fnp-3500	207	1	keyvani1	keyvani1	PROPN
fnp-3500	207	2	1	1	NUM
fnp-3500	207	3	university	university	NOUN
fnp-3500	207	4	duisburg	duisburg	PROPN
fnp-3500	207	5	-	-	PUNCT
fnp-3500	207	6	essen	essen	NOUN
fnp-3500	207	7	,	,	PUNCT
fnp-3500	207	8	institute	institute	NOUN
fnp-3500	207	9	of	of	ADP
fnp-3500	207	10	neuropathology	neuropathology	NOUN
fnp-3500	207	11	,	,	PUNCT
fnp-3500	207	12	essen	essen	PROPN
fnp-3500	207	13	,	,	PUNCT
fnp-3500	207	14	germany	germany	PROPN
fnp-3500	207	15	introduction	introduction	NOUN
fnp-3500	207	16	:	:	PUNCT
fnp-3500	207	17	an	an	DET
fnp-3500	207	18	active	active	ADJ
fnp-3500	207	19	lifestyle	lifestyle	NOUN
fnp-3500	207	20	reduces	reduce	VERB
fnp-3500	207	21	the	the	DET
fnp-3500	207	22	risk	risk	NOUN
fnp-3500	207	23	of	of	ADP
fnp-3500	207	24	dementia	dementia	NOUN
fnp-3500	207	25	and	and	CCONJ
fnp-3500	207	26	cognitive	cognitive	ADJ
fnp-3500	207	27	decline	decline	NOUN
fnp-3500	207	28	in	in	ADP
fnp-3500	207	29	alzheimer"s	alzheimer"s	ADJ
fnp-3500	207	30	diseases	disease	NOUN
fnp-3500	207	31	(	(	PUNCT
fnp-3500	207	32	ad	ad	NOUN
fnp-3500	207	33	)	)	PUNCT
fnp-3500	207	34	patients	patient	NOUN
fnp-3500	207	35	.	.	PUNCT
fnp-3500	208	1	animal	animal	NOUN
fnp-3500	208	2	studies	study	NOUN
fnp-3500	208	3	have	have	AUX
fnp-3500	208	4	shown	show	VERB
fnp-3500	208	5	that	that	SCONJ
fnp-3500	208	6	environmental	environmental	ADJ
fnp-3500	208	7	enrichment	enrichment	NOUN
fnp-3500	208	8	increases	increase	VERB
fnp-3500	208	9	the	the	DET
fnp-3500	208	10	cognitive	cognitive	ADJ
fnp-3500	208	11	reserve	reserve	NOUN
fnp-3500	208	12	and	and	CCONJ
fnp-3500	208	13	interferes	interfere	VERB
fnp-3500	208	14	with	with	ADP
fnp-3500	208	15	the	the	DET
fnp-3500	208	16	pathomechanisms	pathomechanism	NOUN
fnp-3500	208	17	of	of	ADP
fnp-3500	208	18	ad	ad	NOUN
fnp-3500	208	19	over	over	ADP
fnp-3500	208	20	a	a	DET
fnp-3500	208	21	very	very	ADV
fnp-3500	208	22	extended	extended	ADJ
fnp-3500	208	23	period	period	NOUN
fnp-3500	208	24	of	of	ADP
fnp-3500	208	25	ontogenesis	ontogenesis	NOUN
fnp-3500	208	26	,	,	PUNCT
fnp-3500	208	27	from	from	ADP
fnp-3500	208	28	in	in	ADP
fnp-3500	208	29	utero	utero	ADJ
fnp-3500	208	30	stimulation	stimulation	NOUN
fnp-3500	208	31	via	via	ADP
fnp-3500	208	32	maternal	maternal	ADJ
fnp-3500	208	33	running	running	NOUN
fnp-3500	208	34	during	during	ADP
fnp-3500	208	35	pregnancy	pregnancy	NOUN
fnp-3500	208	36	until	until	ADP
fnp-3500	208	37	late	late	ADJ
fnp-3500	208	38	exercise	exercise	NOUN
fnp-3500	208	39	in	in	ADP
fnp-3500	208	40	a	a	DET
fnp-3500	208	41	full	full	ADV
fnp-3500	208	42	-	-	PUNCT
fnp-3500	208	43	blown	blow	VERB
fnp-3500	208	44	stage	stage	NOUN
fnp-3500	208	45	disease	disease	NOUN
fnp-3500	208	46	.	.	PUNCT
fnp-3500	209	1	objectives	objective	NOUN
fnp-3500	209	2	:	:	PUNCT
fnp-3500	209	3	here	here	ADV
fnp-3500	209	4	we	we	PRON
fnp-3500	209	5	asked	ask	VERB
fnp-3500	209	6	whether	whether	SCONJ
fnp-3500	209	7	protective	protective	ADJ
fnp-3500	209	8	effects	effect	NOUN
fnp-3500	209	9	of	of	ADP
fnp-3500	209	10	exercise	exercise	NOUN
fnp-3500	209	11	against	against	ADP
fnp-3500	209	12	ad	ad	NOUN
fnp-3500	209	13	can	can	AUX
fnp-3500	209	14	be	be	AUX
fnp-3500	209	15	inherited	inherit	VERB
fnp-3500	209	16	across	across	ADP
fnp-3500	209	17	several	several	ADJ
fnp-3500	209	18	generations	generation	NOUN
fnp-3500	209	19	and	and	CCONJ
fnp-3500	209	20	if	if	SCONJ
fnp-3500	209	21	so	so	ADV
fnp-3500	209	22	,	,	PUNCT
fnp-3500	209	23	what	what	DET
fnp-3500	209	24	epigenetic	epigenetic	ADJ
fnp-3500	209	25	modifications	modification	NOUN
fnp-3500	209	26	enable	enable	VERB
fnp-3500	209	27	transgenerational	transgenerational	ADJ
fnp-3500	209	28	transmission	transmission	NOUN
fnp-3500	209	29	.	.	PUNCT
fnp-3500	210	1	materials	material	NOUN
fnp-3500	210	2	&	&	CCONJ
fnp-3500	210	3	methods	method	NOUN
fnp-3500	210	4	:	:	PUNCT
fnp-3500	210	5	in	in	ADP
fnp-3500	210	6	the	the	DET
fnp-3500	210	7	founder	founder	NOUN
fnp-3500	210	8	generation	generation	NOUN
fnp-3500	210	9	(	(	PUNCT
fnp-3500	210	10	f0	f0	PROPN
fnp-3500	210	11	)	)	PUNCT
fnp-3500	210	12	,	,	PUNCT
fnp-3500	210	13	tgcrnd8	tgcrnd8	ADJ
fnp-3500	210	14	mice	mouse	NOUN
fnp-3500	210	15	(	(	PUNCT
fnp-3500	210	16	disease	disease	NOUN
fnp-3500	210	17	onset	onset	VERB
fnp-3500	210	18	around	around	ADP
fnp-3500	210	19	postnatal	postnatal	ADJ
fnp-3500	210	20	day	day	NOUN
fnp-3500	210	21	90	90	NUM
fnp-3500	210	22	,	,	PUNCT
fnp-3500	210	23	p90	p90	NOUN
fnp-3500	210	24	)	)	PUNCT
fnp-3500	210	25	and	and	CCONJ
fnp-3500	210	26	wildtype	wildtype	NOUN
fnp-3500	210	27	littermates	littermate	NOUN
fnp-3500	210	28	had	have	VERB
fnp-3500	210	29	either	either	CCONJ
fnp-3500	210	30	access	access	NOUN
fnp-3500	210	31	to	to	ADP
fnp-3500	210	32	voluntary	voluntary	ADJ
fnp-3500	210	33	wheel	wheel	NOUN
fnp-3500	210	34	running	run	VERB
fnp-3500	210	35	for	for	ADP
fnp-3500	210	36	six	six	NUM
fnp-3500	210	37	months	month	NOUN
fnp-3500	210	38	,	,	PUNCT
fnp-3500	210	39	starting	start	VERB
fnp-3500	210	40	at	at	ADP
fnp-3500	210	41	p30	p30	NOUN
fnp-3500	210	42	,	,	PUNCT
fnp-3500	210	43	or	or	CCONJ
fnp-3500	210	44	were	be	AUX
fnp-3500	210	45	housed	house	VERB
fnp-3500	210	46	without	without	ADP
fnp-3500	210	47	exercise	exercise	NOUN
fnp-3500	210	48	(	(	PUNCT
fnp-3500	210	49	control	control	NOUN
fnp-3500	210	50	)	)	PUNCT
fnp-3500	210	51	.	.	PUNCT
fnp-3500	211	1	from	from	ADP
fnp-3500	211	2	p90	p90	NOUN
fnp-3500	211	3	,	,	PUNCT
fnp-3500	211	4	either	either	CCONJ
fnp-3500	211	5	exercised	exercise	VERB
fnp-3500	211	6	mice	mouse	NOUN
fnp-3500	211	7	were	be	AUX
fnp-3500	211	8	mated	mate	VERB
fnp-3500	211	9	or	or	CCONJ
fnp-3500	211	10	mice	mouse	NOUN
fnp-3500	211	11	that	that	PRON
fnp-3500	211	12	experienced	experience	VERB
fnp-3500	211	13	a	a	DET
fnp-3500	211	14	sedentary	sedentary	ADJ
fnp-3500	211	15	life	life	NOUN
fnp-3500	211	16	style	style	NOUN
fnp-3500	211	17	.	.	PUNCT
fnp-3500	212	1	the	the	DET
fnp-3500	212	2	offspring	offspring	NOUN
fnp-3500	212	3	was	be	AUX
fnp-3500	212	4	solely	solely	ADV
fnp-3500	212	5	housed	house	VERB
fnp-3500	212	6	under	under	ADP
fnp-3500	212	7	control	control	NOUN
fnp-3500	212	8	conditions	condition	NOUN
fnp-3500	212	9	and	and	CCONJ
fnp-3500	212	10	crossed	cross	VERB
fnp-3500	212	11	until	until	ADP
fnp-3500	212	12	the	the	DET
fnp-3500	212	13	third	third	ADJ
fnp-3500	212	14	progenitor	progenitor	NOUN
fnp-3500	212	15	generation	generation	NOUN
fnp-3500	212	16	.	.	PUNCT
fnp-3500	213	1	the	the	DET
fnp-3500	213	2	progeny	progeny	NOUN
fnp-3500	213	3	(	(	PUNCT
fnp-3500	213	4	f1	f1	NOUN
fnp-3500	213	5	-	-	PUNCT
fnp-3500	213	6	f3	f3	NOUN
fnp-3500	213	7	)	)	PUNCT
fnp-3500	213	8	was	be	AUX
fnp-3500	213	9	phenotyped	phenotype	VERB
fnp-3500	213	10	for	for	ADP
fnp-3500	213	11	memory	memory	NOUN
fnp-3500	213	12	and	and	CCONJ
fnp-3500	213	13	explorative	explorative	ADJ
fnp-3500	213	14	behaviour	behaviour	NOUN
fnp-3500	213	15	as	as	ADV
fnp-3500	213	16	well	well	ADV
fnp-3500	213	17	as	as	ADP
fnp-3500	213	18	amyloid	amyloid	NOUN
fnp-3500	213	19	beta	beta	NOUN
fnp-3500	213	20	(	(	PUNCT
fnp-3500	213	21	aβ	aβ	NOUN
fnp-3500	213	22	)	)	PUNCT
fnp-3500	213	23	pathology	pathology	NOUN
fnp-3500	213	24	in	in	ADP
fnp-3500	213	25	an	an	DET
fnp-3500	213	26	advanced	advanced	ADJ
fnp-3500	213	27	stage	stage	NOUN
fnp-3500	213	28	disease	disease	NOUN
fnp-3500	213	29	(	(	PUNCT
fnp-3500	213	30	p210	p210	PROPN
fnp-3500	213	31	)	)	PUNCT
fnp-3500	213	32	.	.	PUNCT
fnp-3500	214	1	to	to	PART
fnp-3500	214	2	detect	detect	VERB
fnp-3500	214	3	epigenetic	epigenetic	ADJ
fnp-3500	214	4	transmitters	transmitter	NOUN
fnp-3500	214	5	,	,	PUNCT
fnp-3500	214	6	we	we	PRON
fnp-3500	214	7	determined	determine	VERB
fnp-3500	214	8	the	the	DET
fnp-3500	214	9	cerebral	cerebral	ADJ
fnp-3500	214	10	expression	expression	NOUN
fnp-3500	214	11	profile	profile	NOUN
fnp-3500	214	12	of	of	ADP
fnp-3500	214	13	micrornas	microrna	NOUN
fnp-3500	214	14	involved	involve	VERB
fnp-3500	214	15	in	in	ADP
fnp-3500	214	16	aβ	aβ	DET
fnp-3500	214	17	metabolism	metabolism	NOUN
fnp-3500	214	18	.	.	PUNCT
fnp-3500	215	1	results	result	NOUN
fnp-3500	215	2	:	:	PUNCT
fnp-3500	215	3	we	we	PRON
fnp-3500	215	4	here	here	ADV
fnp-3500	215	5	show	show	VERB
fnp-3500	215	6	that	that	SCONJ
fnp-3500	215	7	great	great	ADJ
fnp-3500	215	8	-	-	PUNCT
fnp-3500	215	9	grandparental	grandparental	NOUN
fnp-3500	215	10	running	running	NOUN
fnp-3500	215	11	reduced	reduce	VERB
fnp-3500	215	12	aβ	aβ	PRON
fnp-3500	215	13	plaque	plaque	NOUN
fnp-3500	215	14	burden	burden	NOUN
fnp-3500	215	15	,	,	PUNCT
fnp-3500	215	16	enhanced	enhance	VERB
fnp-3500	215	17	cerebral	cerebral	ADJ
fnp-3500	215	18	levels	level	NOUN
fnp-3500	215	19	of	of	ADP
fnp-3500	215	20	the	the	DET
fnp-3500	215	21	aβ	aβ	NOUN
fnp-3500	215	22	efflux	efflux	NOUN
fnp-3500	215	23	transporter	transporter	NOUN
fnp-3500	215	24	mdr1	mdr1	PROPN
fnp-3500	215	25	and	and	CCONJ
fnp-3500	215	26	further	far	ADV
fnp-3500	215	27	increased	increase	VERB
fnp-3500	215	28	recognition	recognition	NOUN
fnp-3500	215	29	memory	memory	NOUN
fnp-3500	215	30	and	and	CCONJ
fnp-3500	215	31	explorative	explorative	ADJ
fnp-3500	215	32	behaviour	behaviour	NOUN
fnp-3500	215	33	in	in	ADP
fnp-3500	215	34	transgenic	transgenic	NOUN
fnp-3500	215	35	mice	mouse	NOUN
fnp-3500	215	36	until	until	ADP
fnp-3500	215	37	the	the	DET
fnp-3500	215	38	f3	f3	ADJ
fnp-3500	215	39	generation	generation	NOUN
fnp-3500	215	40	.	.	PUNCT
fnp-3500	216	1	further	far	ADV
fnp-3500	216	2	,	,	PUNCT
fnp-3500	216	3	the	the	DET
fnp-3500	216	4	cerebral	cerebral	ADJ
fnp-3500	216	5	expression	expression	NOUN
fnp-3500	216	6	of	of	ADP
fnp-3500	216	7	micrornas	microrna	NOUN
fnp-3500	216	8	that	that	PRON
fnp-3500	216	9	promote	promote	VERB
fnp-3500	216	10	aβ	aβ	PRON
fnp-3500	216	11	pathology	pathology	NOUN
fnp-3500	216	12	(	(	PUNCT
fnp-3500	216	13	mirnas	mirna	VERB
fnp-3500	216	14	342	342	NUM
fnp-3500	216	15	-	-	SYM
fnp-3500	216	16	3p	3p	NUM
fnp-3500	216	17	,	,	PUNCT
fnp-3500	216	18	16	16	NUM
fnp-3500	216	19	-	-	PUNCT
fnp-3500	216	20	5p	5p	NUM
fnp-3500	216	21	,	,	PUNCT
fnp-3500	216	22	9	9	NUM
fnp-3500	216	23	-	-	PUNCT
fnp-3500	216	24	5p	5p	NUM
fnp-3500	216	25	)	)	PUNCT
fnp-3500	216	26	was	be	AUX
fnp-3500	216	27	strongly	strongly	ADV
fnp-3500	216	28	reduced	reduce	VERB
fnp-3500	216	29	following	follow	VERB
fnp-3500	216	30	ancestral	ancestral	ADJ
fnp-3500	216	31	exercise	exercise	NOUN
fnp-3500	216	32	.	.	PUNCT
fnp-3500	217	1	conclusion	conclusion	NOUN
fnp-3500	217	2	:	:	PUNCT
fnp-3500	217	3	we	we	PRON
fnp-3500	217	4	conclude	conclude	VERB
fnp-3500	217	5	that	that	SCONJ
fnp-3500	217	6	protective	protective	ADJ
fnp-3500	217	7	effects	effect	NOUN
fnp-3500	217	8	of	of	ADP
fnp-3500	217	9	exercise	exercise	NOUN
fnp-3500	217	10	can	can	AUX
fnp-3500	217	11	propagate	propagate	VERB
fnp-3500	217	12	across	across	ADP
fnp-3500	217	13	generations	generation	NOUN
fnp-3500	217	14	.	.	PUNCT
fnp-3500	218	1	ongoing	ongoing	ADJ
fnp-3500	218	2	experiments	experiment	NOUN
fnp-3500	218	3	aim	aim	VERB
fnp-3500	218	4	to	to	PART
fnp-3500	218	5	decode	decode	VERB
fnp-3500	218	6	further	further	ADJ
fnp-3500	218	7	epigenetic	epigenetic	ADJ
fnp-3500	218	8	modifications	modification	NOUN
fnp-3500	218	9	that	that	PRON
fnp-3500	218	10	enable	enable	VERB
fnp-3500	218	11	transgenerational	transgenerational	ADJ
fnp-3500	218	12	inheritance	inheritance	NOUN
fnp-3500	218	13	.	.	PUNCT
fnp-3500	218	14	  	  	SPACE
fnp-3500	219	1	neurooncology	neurooncology	NOUN
fnp-3500	219	2	pediatrics	pediatric	NOUN
fnp-3500	219	3	nop-01	nop-01	ADP
fnp-3500	219	4	free	free	ADJ
fnp-3500	219	5	neuropathol	neuropathol	NOUN
fnp-3500	219	6	2:22:26	2:22:26	NUM
fnp-3500	219	7	co	co	NOUN
fnp-3500	219	8	-	-	NOUN
fnp-3500	219	9	activation	activation	NOUN
fnp-3500	219	10	of	of	ADP
fnp-3500	219	11	sonic	sonic	ADJ
fnp-3500	219	12	hedgehog	hedgehog	NOUN
fnp-3500	219	13	and	and	CCONJ
fnp-3500	219	14	wnt	wnt	NOUN
fnp-3500	219	15	signaling	signal	VERB
fnp-3500	219	16	in	in	ADP
fnp-3500	219	17	murine	murine	ADJ
fnp-3500	219	18	retinal	retinal	ADJ
fnp-3500	219	19	precursor	precursor	NOUN
fnp-3500	219	20	cells	cell	NOUN
fnp-3500	219	21	drives	drive	VERB
fnp-3500	219	22	ocular	ocular	ADJ
fnp-3500	219	23	lesions	lesion	NOUN
fnp-3500	219	24	resembling	resemble	VERB
fnp-3500	219	25	intraocular	intraocular	ADJ
fnp-3500	219	26	medulloepithelioma	medulloepithelioma	ADJ
fnp-3500	219	27	m.	m.	NOUN
fnp-3500	219	28	dottermusch1,2	dottermusch1,2	PROPN
fnp-3500	219	29	,	,	PUNCT
fnp-3500	219	30	p.	p.	PROPN
fnp-3500	219	31	sumislawski1	sumislawski1	PROPN
fnp-3500	219	32	,	,	PUNCT
fnp-3500	219	33	j.	j.	PROPN
fnp-3500	219	34	krevet3,4	krevet3,4	PROPN
fnp-3500	219	35	,	,	PUNCT
fnp-3500	219	36	h.	h.	PROPN
fnp-3500	219	37	voß5	voß5	PROPN
fnp-3500	219	38	,	,	PUNCT
fnp-3500	219	39	m.	m.	NOUN
fnp-3500	219	40	middelkamp1	middelkamp1	PROPN
fnp-3500	219	41	,	,	PUNCT
fnp-3500	219	42	h.	h.	PROPN
fnp-3500	219	43	bartsch6	bartsch6	PROPN
fnp-3500	219	44	,	,	PUNCT
fnp-3500	219	45	k.	k.	PROPN
fnp-3500	219	46	sotlar6,7	sotlar6,7	PROPN
fnp-3500	219	47	,	,	PUNCT
fnp-3500	219	48	a.	a.	PROPN
fnp-3500	219	49	korshunov8	korshunov8	PROPN
fnp-3500	219	50	,	,	PUNCT
fnp-3500	219	51	m.	m.	PROPN
fnp-3500	219	52	glatzel1	glatzel1	PROPN
fnp-3500	219	53	,	,	PUNCT
fnp-3500	219	54	u.	u.	PROPN
fnp-3500	219	55	schüller1,4,9	schüller1,4,9	PROPN
fnp-3500	219	56	,	,	PUNCT
fnp-3500	219	57	j.	j.	PROPN
fnp-3500	219	58	neumann1,2	neumann1,2	PROPN
fnp-3500	219	59	1	1	NUM
fnp-3500	219	60	university	university	NOUN
fnp-3500	219	61	medical	medical	ADJ
fnp-3500	219	62	center	center	NOUN
fnp-3500	219	63	hamburg	hamburg	PROPN
fnp-3500	219	64	-	-	PUNCT
fnp-3500	219	65	eppendorf	eppendorf	PROPN
fnp-3500	219	66	,	,	PUNCT
fnp-3500	219	67	institute	institute	NOUN
fnp-3500	219	68	of	of	ADP
fnp-3500	219	69	neuropathology	neuropathology	NOUN
fnp-3500	219	70	,	,	PUNCT
fnp-3500	219	71	hamburg	hamburg	PROPN
fnp-3500	219	72	,	,	PUNCT
fnp-3500	219	73	germany	germany	PROPN
fnp-3500	219	74	2	2	NUM
fnp-3500	219	75	university	university	NOUN
fnp-3500	219	76	medical	medical	ADJ
fnp-3500	219	77	center	center	NOUN
fnp-3500	219	78	hamburg	hamburg	PROPN
fnp-3500	219	79	-	-	PUNCT
fnp-3500	219	80	eppendorf	eppendorf	PROPN
fnp-3500	219	81	,	,	PUNCT
fnp-3500	219	82	center	center	NOUN
fnp-3500	219	83	for	for	ADP
fnp-3500	219	84	molecular	molecular	ADJ
fnp-3500	219	85	neurobiology	neurobiology	NOUN
fnp-3500	219	86	(	(	PUNCT
fnp-3500	219	87	zmnh	zmnh	NOUN
fnp-3500	219	88	)	)	PUNCT
fnp-3500	219	89	,	,	PUNCT
fnp-3500	219	90	hamburg	hamburg	PROPN
fnp-3500	219	91	,	,	PUNCT
fnp-3500	219	92	germany	germany	PROPN
fnp-3500	219	93	3	3	NUM
fnp-3500	219	94	ludwig	ludwig	PROPN
fnp-3500	219	95	-	-	PUNCT
fnp-3500	219	96	maximilians	maximilians	PROPN
fnp-3500	219	97	-	-	PUNCT
fnp-3500	219	98	university	university	NOUN
fnp-3500	219	99	munich	munich	PROPN
fnp-3500	219	100	,	,	PUNCT
fnp-3500	219	101	center	center	NOUN
fnp-3500	219	102	for	for	ADP
fnp-3500	219	103	neuropathology	neuropathology	NOUN
fnp-3500	219	104	,	,	PUNCT
fnp-3500	219	105	münchen	münchen	PROPN
fnp-3500	219	106	,	,	PUNCT
fnp-3500	219	107	germany	germany	PROPN
fnp-3500	219	108	4	4	NUM
fnp-3500	219	109	research	research	PROPN
fnp-3500	219	110	institute	institute	NOUN
fnp-3500	219	111	children	child	NOUN
fnp-3500	219	112	’s	’s	PART
fnp-3500	219	113	cancer	cancer	NOUN
fnp-3500	219	114	center	center	PROPN
fnp-3500	219	115	hamburg	hamburg	PROPN
fnp-3500	219	116	,	,	PUNCT
fnp-3500	219	117	hamburg	hamburg	PROPN
fnp-3500	219	118	,	,	PUNCT
fnp-3500	219	119	germany	germany	PROPN
fnp-3500	219	120	5	5	NUM
fnp-3500	219	121	university	university	PROPN
fnp-3500	219	122	medical	medical	ADJ
fnp-3500	219	123	center	center	PROPN
fnp-3500	219	124	hamburg	hamburg	PROPN
fnp-3500	219	125	-	-	PUNCT
fnp-3500	219	126	eppendorf	eppendorf	PROPN
fnp-3500	219	127	,	,	PUNCT
fnp-3500	219	128	institute	institute	NOUN
fnp-3500	219	129	of	of	ADP
fnp-3500	219	130	clinical	clinical	ADJ
fnp-3500	219	131	chemistry	chemistry	NOUN
fnp-3500	219	132	and	and	CCONJ
fnp-3500	219	133	laboratory	laboratory	NOUN
fnp-3500	219	134	medicine	medicine	NOUN
fnp-3500	219	135	,	,	PUNCT
fnp-3500	219	136	hamburg	hamburg	PROPN
fnp-3500	219	137	,	,	PUNCT
fnp-3500	219	138	germany	germany	PROPN
fnp-3500	219	139	6	6	NUM
fnp-3500	219	140	ludwig	ludwig	PROPN
fnp-3500	219	141	-	-	PUNCT
fnp-3500	219	142	maximilians	maximilians	PROPN
fnp-3500	219	143	-	-	PUNCT
fnp-3500	219	144	university	university	NOUN
fnp-3500	219	145	munich	munich	PROPN
fnp-3500	219	146	,	,	PUNCT
fnp-3500	219	147	department	department	PROPN
fnp-3500	219	148	of	of	ADP
fnp-3500	219	149	pathology	pathology	PROPN
fnp-3500	219	150	,	,	PUNCT
fnp-3500	219	151	münchen	münchen	PROPN
fnp-3500	219	152	,	,	PUNCT
fnp-3500	219	153	germany	germany	PROPN
fnp-3500	219	154	7	7	NUM
fnp-3500	219	155	paracelsus	paracelsus	PROPN
fnp-3500	219	156	medical	medical	PROPN
fnp-3500	219	157	university	university	PROPN
fnp-3500	219	158	,	,	PUNCT
fnp-3500	219	159	department	department	NOUN
fnp-3500	219	160	of	of	ADP
fnp-3500	219	161	pathology	pathology	PROPN
fnp-3500	219	162	,	,	PUNCT
fnp-3500	219	163	salzburg	salzburg	PROPN
fnp-3500	219	164	,	,	PUNCT
fnp-3500	219	165	austria	austria	PROPN
fnp-3500	219	166	8	8	NUM
fnp-3500	219	167	german	german	ADJ
fnp-3500	219	168	cancer	cancer	NOUN
fnp-3500	219	169	consortium	consortium	NOUN
fnp-3500	219	170	(	(	PUNCT
fnp-3500	219	171	dktk	dktk	NOUN
fnp-3500	219	172	)	)	PUNCT
fnp-3500	219	173	,	,	PUNCT
fnp-3500	219	174	german	german	ADJ
fnp-3500	219	175	cancer	cancer	NOUN
fnp-3500	219	176	research	research	NOUN
fnp-3500	219	177	center	center	NOUN
fnp-3500	219	178	(	(	PUNCT
fnp-3500	219	179	dkfz	dkfz	NOUN
fnp-3500	219	180	)	)	PUNCT
fnp-3500	219	181	,	,	PUNCT
fnp-3500	219	182	clinical	clinical	ADJ
fnp-3500	219	183	cooperation	cooperation	NOUN
fnp-3500	219	184	unit	unit	NOUN
fnp-3500	219	185	neuropathology	neuropathology	NOUN
fnp-3500	219	186	(	(	PUNCT
fnp-3500	219	187	g380	g380	PROPN
fnp-3500	219	188	)	)	PUNCT
fnp-3500	219	189	,	,	PUNCT
fnp-3500	219	190	heidelberg	heidelberg	PROPN
fnp-3500	219	191	,	,	PUNCT
fnp-3500	219	192	germany	germany	PROPN
fnp-3500	219	193	9	9	NUM
fnp-3500	219	194	university	university	PROPN
fnp-3500	219	195	medical	medical	ADJ
fnp-3500	219	196	center	center	PROPN
fnp-3500	219	197	hamburg	hamburg	PROPN
fnp-3500	219	198	-	-	PUNCT
fnp-3500	219	199	eppendorf	eppendorf	PROPN
fnp-3500	219	200	,	,	PUNCT
fnp-3500	219	201	department	department	NOUN
fnp-3500	219	202	of	of	ADP
fnp-3500	219	203	pediatric	pediatric	ADJ
fnp-3500	219	204	hematology	hematology	NOUN
fnp-3500	219	205	and	and	CCONJ
fnp-3500	219	206	oncology	oncology	NOUN
fnp-3500	219	207	,	,	PUNCT
fnp-3500	219	208	hamburg	hamburg	PROPN
fnp-3500	219	209	,	,	PUNCT
fnp-3500	219	210	germany	germany	PROPN
fnp-3500	219	211	introduction	introduction	NOUN
fnp-3500	219	212	:	:	PUNCT
fnp-3500	219	213	intraocular	intraocular	ADJ
fnp-3500	219	214	medulloepithelioma	medulloepithelioma	NOUN
fnp-3500	219	215	(	(	PUNCT
fnp-3500	219	216	io	io	NOUN
fnp-3500	219	217	-	-	NOUN
fnp-3500	219	218	mepl	mepl	NOUN
fnp-3500	219	219	)	)	PUNCT
fnp-3500	219	220	is	be	AUX
fnp-3500	219	221	a	a	DET
fnp-3500	219	222	rare	rare	ADJ
fnp-3500	219	223	embryonal	embryonal	ADJ
fnp-3500	219	224	ocular	ocular	ADJ
fnp-3500	219	225	neoplasm	neoplasm	NOUN
fnp-3500	219	226	,	,	PUNCT
fnp-3500	219	227	which	which	PRON
fnp-3500	219	228	prevalently	prevalently	ADV
fnp-3500	219	229	occurs	occur	VERB
fnp-3500	219	230	in	in	ADP
fnp-3500	219	231	young	young	ADJ
fnp-3500	219	232	children	child	NOUN
fnp-3500	219	233	and	and	CCONJ
fnp-3500	219	234	is	be	AUX
fnp-3500	219	235	commonly	commonly	ADV
fnp-3500	219	236	treated	treat	VERB
fnp-3500	219	237	by	by	ADP
fnp-3500	219	238	enucleation	enucleation	NOUN
fnp-3500	219	239	of	of	ADP
fnp-3500	219	240	the	the	DET
fnp-3500	219	241	eye	eye	NOUN
fnp-3500	219	242	.	.	PUNCT
fnp-3500	220	1	io	io	NOUN
fnp-3500	220	2	-	-	PROPN
fnp-3500	220	3	mepls	mepls	PROPN
fnp-3500	220	4	share	share	VERB
fnp-3500	220	5	common	common	ADJ
fnp-3500	220	6	histomorphological	histomorphological	ADJ
fnp-3500	220	7	features	feature	NOUN
fnp-3500	220	8	with	with	ADP
fnp-3500	220	9	variants	variant	NOUN
fnp-3500	220	10	of	of	ADP
fnp-3500	220	11	cns	cns	PROPN
fnp-3500	220	12	embryonal	embryonal	ADJ
fnp-3500	220	13	tumors	tumor	NOUN
fnp-3500	220	14	with	with	ADP
fnp-3500	220	15	multilayered	multilayered	ADJ
fnp-3500	220	16	rosettes	rosette	NOUN
fnp-3500	220	17	(	(	PUNCT
fnp-3500	220	18	etmr	etmr	ADV
fnp-3500	220	19	)	)	PUNCT
fnp-3500	220	20	,	,	PUNCT
fnp-3500	220	21	referred	refer	VERB
fnp-3500	220	22	to	to	ADP
fnp-3500	220	23	as	as	ADP
fnp-3500	220	24	intracranial	intracranial	ADJ
fnp-3500	220	25	medulloepitheliomas	medulloepithelioma	NOUN
fnp-3500	220	26	.	.	PUNCT
fnp-3500	221	1	while	while	SCONJ
fnp-3500	221	2	sonic	sonic	ADJ
fnp-3500	221	3	hedgehog	hedgehog	PROPN
fnp-3500	221	4	(	(	PUNCT
fnp-3500	221	5	shh	shh	NOUN
fnp-3500	221	6	)	)	PUNCT
fnp-3500	221	7	and	and	CCONJ
fnp-3500	221	8	wnt	wnt	NOUN
fnp-3500	221	9	signaling	signal	VERB
fnp-3500	221	10	pathways	pathway	NOUN
fnp-3500	221	11	are	be	AUX
fnp-3500	221	12	crucial	crucial	ADJ
fnp-3500	221	13	for	for	ADP
fnp-3500	221	14	etmr	etmr	ADJ
fnp-3500	221	15	pathogenesis	pathogenesis	NOUN
fnp-3500	221	16	,	,	PUNCT
fnp-3500	221	17	the	the	DET
fnp-3500	221	18	impact	impact	NOUN
fnp-3500	221	19	of	of	ADP
fnp-3500	221	20	these	these	DET
fnp-3500	221	21	pathways	pathway	NOUN
fnp-3500	221	22	on	on	ADP
fnp-3500	221	23	human	human	PROPN
fnp-3500	221	24	io	io	PROPN
fnp-3500	221	25	-	-	PROPN
fnp-3500	221	26	mepl	mepl	PROPN
fnp-3500	221	27	development	development	NOUN
fnp-3500	221	28	is	be	AUX
fnp-3500	221	29	unclear	unclear	ADJ
fnp-3500	221	30	.	.	PUNCT
fnp-3500	222	1	objectives	objective	NOUN
fnp-3500	222	2	:	:	PUNCT
fnp-3500	222	3	our	our	PRON
fnp-3500	222	4	objective	objective	NOUN
fnp-3500	222	5	in	in	ADP
fnp-3500	222	6	this	this	DET
fnp-3500	222	7	study	study	NOUN
fnp-3500	222	8	was	be	AUX
fnp-3500	222	9	to	to	PART
fnp-3500	222	10	explore	explore	VERB
fnp-3500	222	11	the	the	DET
fnp-3500	222	12	relevance	relevance	NOUN
fnp-3500	222	13	of	of	ADP
fnp-3500	222	14	shh	shh	NOUN
fnp-3500	222	15	and	and	CCONJ
fnp-3500	222	16	wnt	wnt	NOUN
fnp-3500	222	17	signaling	signal	VERB
fnp-3500	222	18	in	in	ADP
fnp-3500	222	19	human	human	PROPN
fnp-3500	222	20	io	io	PROPN
fnp-3500	222	21	-	-	NOUN
fnp-3500	222	22	mepls	mepls	PROPN
fnp-3500	222	23	and	and	CCONJ
fnp-3500	222	24	demonstrate	demonstrate	VERB
fnp-3500	222	25	the	the	DET
fnp-3500	222	26	effect	effect	NOUN
fnp-3500	222	27	of	of	ADP
fnp-3500	222	28	simultaneous	simultaneous	ADJ
fnp-3500	222	29	shh	shh	NOUN
fnp-3500	222	30	and	and	CCONJ
fnp-3500	222	31	wnt	wnt	PROPN
fnp-3500	222	32	activation	activation	NOUN
fnp-3500	222	33	in	in	ADP
fnp-3500	222	34	mouse	mouse	NOUN
fnp-3500	222	35	retinal	retinal	ADJ
fnp-3500	222	36	precursor	precursor	NOUN
fnp-3500	222	37	cells	cell	NOUN
fnp-3500	222	38	.	.	PUNCT
fnp-3500	223	1	materials	material	NOUN
fnp-3500	223	2	&	&	CCONJ
fnp-3500	223	3	methods	method	NOUN
fnp-3500	223	4	:	:	PUNCT
fnp-3500	223	5	using	use	VERB
fnp-3500	223	6	nanostring	nanostre	VERB
fnp-3500	223	7	technology	technology	NOUN
fnp-3500	223	8	,	,	PUNCT
fnp-3500	223	9	gene	gene	NOUN
fnp-3500	223	10	expression	expression	NOUN
fnp-3500	223	11	data	datum	NOUN
fnp-3500	223	12	was	be	AUX
fnp-3500	223	13	obtained	obtain	VERB
fnp-3500	223	14	from	from	ADP
fnp-3500	223	15	ffpe	ffpe	ADJ
fnp-3500	223	16	tumor	tumor	NOUN
fnp-3500	223	17	samples	sample	NOUN
fnp-3500	223	18	of	of	ADP
fnp-3500	223	19	8	8	NUM
fnp-3500	223	20	human	human	PROPN
fnp-3500	223	21	io	io	PROPN
fnp-3500	223	22	-	-	NOUN
fnp-3500	223	23	mepls	mepls	NOUN
fnp-3500	223	24	,	,	PUNCT
fnp-3500	223	25	as	as	ADV
fnp-3500	223	26	well	well	ADV
fnp-3500	223	27	as	as	ADP
fnp-3500	223	28	16	16	NUM
fnp-3500	223	29	intracranial	intracranial	ADJ
fnp-3500	223	30	embryonal	embryonal	ADJ
fnp-3500	223	31	tumors	tumor	NOUN
fnp-3500	223	32	comprising	comprise	VERB
fnp-3500	223	33	etmrs	etmrs	NOUN
fnp-3500	223	34	,	,	PUNCT
fnp-3500	223	35	shh	shh	NOUN
fnp-3500	223	36	-	-	PUNCT
fnp-3500	223	37	medulloblastomas	medulloblastoma	NOUN
fnp-3500	223	38	(	(	PUNCT
fnp-3500	223	39	mbs	mb	NOUN
fnp-3500	223	40	)	)	PUNCT
fnp-3500	223	41	,	,	PUNCT
fnp-3500	223	42	wnt	wnt	PROPN
fnp-3500	223	43	-	-	PUNCT
fnp-3500	223	44	mbs	mb	NOUN
fnp-3500	223	45	and	and	CCONJ
fnp-3500	223	46	group	group	NOUN
fnp-3500	223	47	4	4	NUM
fnp-3500	223	48	-	-	PUNCT
fnp-3500	223	49	mbs	mbs	NOUN
fnp-3500	223	50	.	.	PUNCT
fnp-3500	224	1	in	in	ADP
fnp-3500	224	2	order	order	NOUN
fnp-3500	224	3	to	to	PART
fnp-3500	224	4	unravel	unravel	VERB
fnp-3500	224	5	the	the	DET
fnp-3500	224	6	function	function	NOUN
fnp-3500	224	7	of	of	ADP
fnp-3500	224	8	shh	shh	NOUN
fnp-3500	224	9	and	and	CCONJ
fnp-3500	224	10	wnt	wnt	NOUN
fnp-3500	224	11	signaling	signal	VERB
fnp-3500	224	12	for	for	ADP
fnp-3500	224	13	io	io	PROPN
fnp-3500	224	14	-	-	PROPN
fnp-3500	224	15	mepl	mepl	PROPN
fnp-3500	224	16	pathogenesis	pathogenesis	NOUN
fnp-3500	224	17	in	in	ADP
fnp-3500	224	18	vivo	vivo	NOUN
fnp-3500	224	19	in	in	ADP
fnp-3500	224	20	a	a	DET
fnp-3500	224	21	time	time	NOUN
fnp-3500	224	22	point	point	NOUN
fnp-3500	224	23	and	and	CCONJ
fnp-3500	224	24	cell	cell	NOUN
fnp-3500	224	25	specific	specific	ADJ
fnp-3500	224	26	manner	manner	NOUN
fnp-3500	224	27	,	,	PUNCT
fnp-3500	224	28	the	the	DET
fnp-3500	224	29	tamoxifen	tamoxifen	NOUN
fnp-3500	224	30	inducible	inducible	ADJ
fnp-3500	224	31	creert2	creert2	NOUN
fnp-3500	224	32	-	-	PUNCT
fnp-3500	224	33	lox	lox	PROPN
fnp-3500	224	34	system	system	NOUN
fnp-3500	224	35	was	be	AUX
fnp-3500	224	36	utilized	utilize	VERB
fnp-3500	224	37	to	to	PART
fnp-3500	224	38	activate	activate	VERB
fnp-3500	224	39	shh	shh	NOUN
fnp-3500	224	40	and	and	CCONJ
fnp-3500	224	41	wnt	wnt	NOUN
fnp-3500	224	42	signaling	signal	VERB
fnp-3500	224	43	in	in	ADP
fnp-3500	224	44	sox2or	sox2or	ADJ
fnp-3500	224	45	raxexpressing	raxexpresse	VERB
fnp-3500	224	46	retinal	retinal	ADJ
fnp-3500	224	47	precursor	precursor	NOUN
fnp-3500	224	48	cells	cell	NOUN
fnp-3500	224	49	.	.	PUNCT
fnp-3500	225	1	results	result	NOUN
fnp-3500	225	2	:	:	PUNCT
fnp-3500	225	3	io	io	NOUN
fnp-3500	225	4	-	-	NOUN
fnp-3500	225	5	mepls	mepls	PROPN
fnp-3500	225	6	and	and	CCONJ
fnp-3500	225	7	etmrs	etmrs	NOUN
fnp-3500	225	8	displayed	display	VERB
fnp-3500	225	9	similar	similar	ADJ
fnp-3500	225	10	gene	gene	NOUN
fnp-3500	225	11	expression	expression	NOUN
fnp-3500	225	12	patterns	pattern	NOUN
fnp-3500	225	13	and	and	CCONJ
fnp-3500	225	14	significant	significant	ADJ
fnp-3500	225	15	simultaneous	simultaneous	ADJ
fnp-3500	225	16	overrepresentation	overrepresentation	NOUN
fnp-3500	225	17	of	of	ADP
fnp-3500	225	18	both	both	CCONJ
fnp-3500	225	19	shh	shh	PROPN
fnp-3500	225	20	and	and	CCONJ
fnp-3500	225	21	wnt	wnt	PROPN
fnp-3500	225	22	target	target	NOUN
fnp-3500	225	23	genes	gene	NOUN
fnp-3500	225	24	.	.	PUNCT
fnp-3500	226	1	co	co	NOUN
fnp-3500	226	2	-	-	NOUN
fnp-3500	226	3	activation	activation	NOUN
fnp-3500	226	4	of	of	ADP
fnp-3500	226	5	both	both	DET
fnp-3500	226	6	pathways	pathway	NOUN
fnp-3500	226	7	in	in	ADP
fnp-3500	226	8	early	early	ADJ
fnp-3500	226	9	sox2or	sox2or	ADJ
fnp-3500	226	10	raxexpressing	raxexpresse	VERB
fnp-3500	226	11	precursor	precursor	NOUN
fnp-3500	226	12	cells	cell	NOUN
fnp-3500	226	13	resulted	result	VERB
fnp-3500	226	14	in	in	ADP
fnp-3500	226	15	infiltrative	infiltrative	ADJ
fnp-3500	226	16	ocular	ocular	ADJ
fnp-3500	226	17	lesions	lesion	NOUN
fnp-3500	226	18	that	that	PRON
fnp-3500	226	19	displayed	display	VERB
fnp-3500	226	20	extraocular	extraocular	ADJ
fnp-3500	226	21	expansion	expansion	NOUN
fnp-3500	226	22	.	.	PUNCT
fnp-3500	227	1	histomorphological	histomorphological	ADJ
fnp-3500	227	2	,	,	PUNCT
fnp-3500	227	3	immunohistochemical	immunohistochemical	ADJ
fnp-3500	227	4	and	and	CCONJ
fnp-3500	227	5	molecular	molecular	ADJ
fnp-3500	227	6	features	feature	NOUN
fnp-3500	227	7	of	of	ADP
fnp-3500	227	8	these	these	DET
fnp-3500	227	9	lesions	lesion	NOUN
fnp-3500	227	10	revealed	reveal	VERB
fnp-3500	227	11	strong	strong	ADJ
fnp-3500	227	12	concordance	concordance	NOUN
fnp-3500	227	13	with	with	ADP
fnp-3500	227	14	those	those	PRON
fnp-3500	227	15	of	of	ADP
fnp-3500	227	16	human	human	PROPN
fnp-3500	227	17	io	io	PROPN
fnp-3500	227	18	-	-	NOUN
fnp-3500	227	19	mepls	mepls	NOUN
fnp-3500	227	20	.	.	PUNCT
fnp-3500	228	1	conclusion	conclusion	NOUN
fnp-3500	228	2	:	:	PUNCT
fnp-3500	228	3	we	we	PRON
fnp-3500	228	4	report	report	VERB
fnp-3500	228	5	a	a	DET
fnp-3500	228	6	relevant	relevant	ADJ
fnp-3500	228	7	role	role	NOUN
fnp-3500	228	8	of	of	ADP
fnp-3500	228	9	wnt	wnt	NOUN
fnp-3500	228	10	and	and	CCONJ
fnp-3500	228	11	shh	shh	NOUN
fnp-3500	228	12	signaling	signal	VERB
fnp-3500	228	13	in	in	ADP
fnp-3500	228	14	io	io	NOUN
fnp-3500	228	15	-	-	NOUN
fnp-3500	228	16	mepl	mepl	PROPN
fnp-3500	228	17	and	and	CCONJ
fnp-3500	228	18	report	report	VERB
fnp-3500	228	19	a	a	DET
fnp-3500	228	20	mouse	mouse	NOUN
fnp-3500	228	21	model	model	NOUN
fnp-3500	228	22	for	for	ADP
fnp-3500	228	23	this	this	DET
fnp-3500	228	24	rare	rare	ADJ
fnp-3500	228	25	disease	disease	NOUN
fnp-3500	228	26	,	,	PUNCT
fnp-3500	228	27	setting	set	VERB
fnp-3500	228	28	the	the	DET
fnp-3500	228	29	foundation	foundation	NOUN
fnp-3500	228	30	for	for	ADP
fnp-3500	228	31	a	a	DET
fnp-3500	228	32	targeted	target	VERB
fnp-3500	228	33	therapeutic	therapeutic	ADJ
fnp-3500	228	34	approach	approach	NOUN
fnp-3500	228	35	with	with	ADP
fnp-3500	228	36	the	the	DET
fnp-3500	228	37	aim	aim	NOUN
fnp-3500	228	38	of	of	ADP
fnp-3500	228	39	more	more	ADV
fnp-3500	228	40	commonly	commonly	ADV
fnp-3500	228	41	feasible	feasible	ADJ
fnp-3500	228	42	eye	eye	NOUN
fnp-3500	228	43	salvage	salvage	NOUN
fnp-3500	228	44	in	in	ADP
fnp-3500	228	45	affected	affected	ADJ
fnp-3500	228	46	patients	patient	NOUN
fnp-3500	228	47	.	.	PUNCT
fnp-3500	228	48	  	  	SPACE
fnp-3500	229	1	nop-02	nop-02	ADV
fnp-3500	229	2	free	free	ADJ
fnp-3500	229	3	neuropathol	neuropathol	NOUN
fnp-3500	229	4	2:22:28	2:22:28	NUM
fnp-3500	229	5	characterisation	characterisation	NOUN
fnp-3500	229	6	of	of	ADP
fnp-3500	229	7	spinal	spinal	ADJ
fnp-3500	229	8	diffuse	diffuse	NOUN
fnp-3500	229	9	midline	midline	NOUN
fnp-3500	229	10	gliomas	glioma	NOUN
fnp-3500	229	11	l.	l.	PROPN
fnp-3500	229	12	stegat1	stegat1	PROPN
fnp-3500	229	13	,	,	PUNCT
fnp-3500	229	14	u.	u.	PROPN
fnp-3500	229	15	schüller1,2,3	schüller1,2,3	PROPN
fnp-3500	229	16	,	,	PUNCT
fnp-3500	229	17	a.	a.	PROPN
fnp-3500	229	18	wefers1	wefers1	PROPN
fnp-3500	229	19	1	1	NUM
fnp-3500	229	20	university	university	PROPN
fnp-3500	229	21	medical	medical	ADJ
fnp-3500	229	22	center	center	NOUN
fnp-3500	229	23	hamburg	hamburg	PROPN
fnp-3500	229	24	-	-	PUNCT
fnp-3500	229	25	eppendorf	eppendorf	PROPN
fnp-3500	229	26	,	,	PUNCT
fnp-3500	229	27	institute	institute	NOUN
fnp-3500	229	28	of	of	ADP
fnp-3500	229	29	neuropathology	neuropathology	NOUN
fnp-3500	229	30	,	,	PUNCT
fnp-3500	229	31	hamburg	hamburg	PROPN
fnp-3500	229	32	,	,	PUNCT
fnp-3500	229	33	germany	germany	PROPN
fnp-3500	229	34	2	2	NUM
fnp-3500	229	35	university	university	NOUN
fnp-3500	229	36	medical	medical	ADJ
fnp-3500	229	37	center	center	NOUN
fnp-3500	229	38	hamburg	hamburg	PROPN
fnp-3500	229	39	-	-	PUNCT
fnp-3500	229	40	eppendorf	eppendorf	PROPN
fnp-3500	229	41	,	,	PUNCT
fnp-3500	229	42	department	department	NOUN
fnp-3500	229	43	of	of	ADP
fnp-3500	229	44	pediatric	pediatric	ADJ
fnp-3500	229	45	hematology	hematology	NOUN
fnp-3500	229	46	and	and	CCONJ
fnp-3500	229	47	oncology	oncology	NOUN
fnp-3500	229	48	,	,	PUNCT
fnp-3500	229	49	hamburg	hamburg	PROPN
fnp-3500	229	50	,	,	PUNCT
fnp-3500	229	51	germany	germany	PROPN
fnp-3500	229	52	3	3	NUM
fnp-3500	229	53	research	research	PROPN
fnp-3500	229	54	institute	institute	PROPN
fnp-3500	229	55	children	child	NOUN
fnp-3500	229	56	’s	’s	PART
fnp-3500	229	57	cancer	cancer	NOUN
fnp-3500	229	58	center	center	PROPN
fnp-3500	229	59	hamburg	hamburg	PROPN
fnp-3500	229	60	,	,	PUNCT
fnp-3500	229	61	hamburg	hamburg	PROPN
fnp-3500	229	62	,	,	PUNCT
fnp-3500	229	63	germany	germany	PROPN
fnp-3500	229	64	introduction	introduction	NOUN
fnp-3500	229	65	:	:	PUNCT
fnp-3500	229	66	diffuse	diffuse	VERB
fnp-3500	229	67	midline	midline	NOUN
fnp-3500	229	68	gliomas	glioma	NOUN
fnp-3500	229	69	(	(	PUNCT
fnp-3500	229	70	dmgs	dmgs	PROPN
fnp-3500	229	71	)	)	PUNCT
fnp-3500	229	72	are	be	AUX
fnp-3500	229	73	malignant	malignant	ADJ
fnp-3500	229	74	gliomas	glioma	NOUN
fnp-3500	229	75	that	that	PRON
fnp-3500	229	76	grow	grow	VERB
fnp-3500	229	77	in	in	ADP
fnp-3500	229	78	midline	midline	NOUN
fnp-3500	229	79	structures	structure	NOUN
fnp-3500	229	80	of	of	ADP
fnp-3500	229	81	the	the	DET
fnp-3500	229	82	central	central	ADJ
fnp-3500	229	83	nervous	nervous	ADJ
fnp-3500	229	84	system	system	NOUN
fnp-3500	229	85	.	.	PUNCT
fnp-3500	230	1	due	due	ADP
fnp-3500	230	2	to	to	ADP
fnp-3500	230	3	their	their	PRON
fnp-3500	230	4	aggressive	aggressive	ADJ
fnp-3500	230	5	and	and	CCONJ
fnp-3500	230	6	diffuse	diffuse	VERB
fnp-3500	230	7	growth	growth	NOUN
fnp-3500	230	8	and	and	CCONJ
fnp-3500	230	9	a	a	DET
fnp-3500	230	10	two	two	NUM
fnp-3500	230	11	-	-	PUNCT
fnp-3500	230	12	year	year	NOUN
fnp-3500	230	13	survival	survival	NOUN
fnp-3500	230	14	rate	rate	NOUN
fnp-3500	230	15	of	of	ADP
fnp-3500	230	16	less	less	ADJ
fnp-3500	230	17	than	than	ADP
fnp-3500	230	18	10	10	NUM
fnp-3500	230	19	%	%	NOUN
fnp-3500	230	20	,	,	PUNCT
fnp-3500	230	21	dmgs	dmgs	PROPN
fnp-3500	230	22	are	be	AUX
fnp-3500	230	23	graded	grade	VERB
fnp-3500	230	24	as	as	ADP
fnp-3500	230	25	who	who	PRON
fnp-3500	230	26	grade	grade	NOUN
fnp-3500	230	27	iv	iv	NUM
fnp-3500	230	28	.	.	PUNCT
fnp-3500	231	1	depending	depend	VERB
fnp-3500	231	2	on	on	ADP
fnp-3500	231	3	the	the	DET
fnp-3500	231	4	localization	localization	NOUN
fnp-3500	231	5	,	,	PUNCT
fnp-3500	231	6	median	median	ADJ
fnp-3500	231	7	age	age	NOUN
fnp-3500	231	8	of	of	ADP
fnp-3500	231	9	patients	patient	NOUN
fnp-3500	231	10	is	be	AUX
fnp-3500	231	11	about	about	ADV
fnp-3500	231	12	11	11	NUM
fnp-3500	231	13	-	-	SYM
fnp-3500	231	14	20	20	NUM
fnp-3500	231	15	years	year	NOUN
fnp-3500	231	16	.	.	PUNCT
fnp-3500	232	1	genetically	genetically	ADV
fnp-3500	232	2	,	,	PUNCT
fnp-3500	232	3	tumors	tumor	NOUN
fnp-3500	232	4	are	be	AUX
fnp-3500	232	5	defined	define	VERB
fnp-3500	232	6	by	by	ADP
fnp-3500	232	7	a	a	DET
fnp-3500	232	8	k27m	k27m	NOUN
fnp-3500	232	9	-	-	NOUN
fnp-3500	232	10	mutation	mutation	NOUN
fnp-3500	232	11	in	in	ADP
fnp-3500	232	12	one	one	NUM
fnp-3500	232	13	of	of	ADP
fnp-3500	232	14	the	the	DET
fnp-3500	232	15	highly	highly	ADV
fnp-3500	232	16	homologous	homologous	ADJ
fnp-3500	232	17	genes	gene	NOUN
fnp-3500	232	18	encoding	encode	VERB
fnp-3500	232	19	histone	histone	NOUN
fnp-3500	232	20	protein	protein	NOUN
fnp-3500	232	21	h3	h3	NOUN
fnp-3500	232	22	.	.	PUNCT
fnp-3500	233	1	while	while	SCONJ
fnp-3500	233	2	some	some	DET
fnp-3500	233	3	studies	study	NOUN
fnp-3500	233	4	state	state	VERB
fnp-3500	233	5	that	that	SCONJ
fnp-3500	233	6	the	the	DET
fnp-3500	233	7	global	global	ADJ
fnp-3500	233	8	dna	dna	PROPN
fnp-3500	233	9	methylation	methylation	NOUN
fnp-3500	233	10	pattern	pattern	NOUN
fnp-3500	233	11	is	be	AUX
fnp-3500	233	12	correlated	correlate	VERB
fnp-3500	233	13	with	with	ADP
fnp-3500	233	14	the	the	DET
fnp-3500	233	15	mutated	mutate	VERB
fnp-3500	233	16	histone	histone	NOUN
fnp-3500	233	17	gene	gene	NOUN
fnp-3500	233	18	,	,	PUNCT
fnp-3500	233	19	others	other	NOUN
fnp-3500	233	20	suggest	suggest	VERB
fnp-3500	233	21	that	that	SCONJ
fnp-3500	233	22	it	it	PRON
fnp-3500	233	23	differs	differ	VERB
fnp-3500	233	24	between	between	ADP
fnp-3500	233	25	dmgs	dmgs	NOUN
fnp-3500	233	26	of	of	ADP
fnp-3500	233	27	different	different	ADJ
fnp-3500	233	28	localisations	localisation	NOUN
fnp-3500	233	29	.	.	PUNCT
fnp-3500	234	1	objectives	objective	NOUN
fnp-3500	234	2	:	:	PUNCT
fnp-3500	234	3	since	since	SCONJ
fnp-3500	234	4	dmgs	dmgs	NOUN
fnp-3500	234	5	most	most	ADV
fnp-3500	234	6	frequently	frequently	ADV
fnp-3500	234	7	occur	occur	VERB
fnp-3500	234	8	in	in	ADP
fnp-3500	234	9	pons	pon	NOUN
fnp-3500	234	10	and	and	CCONJ
fnp-3500	234	11	thalamus	thalamus	VERB
fnp-3500	234	12	,	,	PUNCT
fnp-3500	234	13	comparatively	comparatively	ADV
fnp-3500	234	14	little	little	ADJ
fnp-3500	234	15	is	be	AUX
fnp-3500	234	16	known	know	VERB
fnp-3500	234	17	about	about	ADP
fnp-3500	234	18	spinal	spinal	NOUN
fnp-3500	234	19	dmgs	dmgs	NOUN
fnp-3500	234	20	.	.	PUNCT
fnp-3500	235	1	therefore	therefore	ADV
fnp-3500	235	2	,	,	PUNCT
fnp-3500	235	3	we	we	PRON
fnp-3500	235	4	histologically	histologically	ADV
fnp-3500	235	5	,	,	PUNCT
fnp-3500	235	6	molecularly	molecularly	ADV
fnp-3500	235	7	and	and	CCONJ
fnp-3500	235	8	clinically	clinically	ADV
fnp-3500	235	9	characterised	characterise	VERB
fnp-3500	235	10	spinal	spinal	NOUN
fnp-3500	235	11	dmgs	dmgs	NOUN
fnp-3500	235	12	and	and	CCONJ
fnp-3500	235	13	analysed	analyse	VERB
fnp-3500	235	14	in	in	ADP
fnp-3500	235	15	which	which	PRON
fnp-3500	235	16	aspects	aspect	NOUN
fnp-3500	235	17	they	they	PRON
fnp-3500	235	18	differ	differ	VERB
fnp-3500	235	19	from	from	ADP
fnp-3500	235	20	dmgs	dmgs	NOUN
fnp-3500	235	21	of	of	ADP
fnp-3500	235	22	other	other	ADJ
fnp-3500	235	23	localizations	localization	NOUN
fnp-3500	235	24	as	as	SCONJ
fnp-3500	235	25	this	this	PRON
fnp-3500	235	26	may	may	AUX
fnp-3500	235	27	have	have	VERB
fnp-3500	235	28	diagnostical	diagnostical	ADJ
fnp-3500	235	29	and/or	and/or	CCONJ
fnp-3500	235	30	clinical	clinical	ADJ
fnp-3500	235	31	implications	implication	NOUN
fnp-3500	235	32	.	.	PUNCT
fnp-3500	236	1	materials	material	NOUN
fnp-3500	236	2	&	&	CCONJ
fnp-3500	236	3	methods	method	NOUN
fnp-3500	236	4	:	:	PUNCT
fnp-3500	236	5	our	our	PRON
fnp-3500	236	6	cohort	cohort	NOUN
fnp-3500	236	7	currently	currently	ADV
fnp-3500	236	8	consists	consist	VERB
fnp-3500	236	9	of	of	ADP
fnp-3500	236	10	17	17	NUM
fnp-3500	236	11	spinal	spinal	NOUN
fnp-3500	236	12	dmgs	dmgs	NOUN
fnp-3500	236	13	plus	plus	CCONJ
fnp-3500	236	14	dmgs	dmgs	NOUN
fnp-3500	236	15	of	of	ADP
fnp-3500	236	16	different	different	ADJ
fnp-3500	236	17	localisations	localisation	NOUN
fnp-3500	236	18	.	.	PUNCT
fnp-3500	237	1	histological	histological	ADJ
fnp-3500	237	2	and	and	CCONJ
fnp-3500	237	3	immunohistochemical	immunohistochemical	ADJ
fnp-3500	237	4	analysis	analysis	NOUN
fnp-3500	237	5	as	as	ADV
fnp-3500	237	6	well	well	ADV
fnp-3500	237	7	as	as	ADP
fnp-3500	237	8	molecular	molecular	ADJ
fnp-3500	237	9	analyses	analysis	NOUN
fnp-3500	237	10	(	(	PUNCT
fnp-3500	237	11	dna	dna	NOUN
fnp-3500	237	12	methylation	methylation	NOUN
fnp-3500	237	13	,	,	PUNCT
fnp-3500	237	14	dna	dna	PROPN
fnp-3500	237	15	panel	panel	NOUN
fnp-3500	237	16	sequencing	sequence	VERB
fnp-3500	237	17	)	)	PUNCT
fnp-3500	237	18	were	be	AUX
fnp-3500	237	19	done	do	VERB
fnp-3500	237	20	from	from	ADP
fnp-3500	237	21	ffpe	ffpe	ADJ
fnp-3500	237	22	tissue	tissue	NOUN
fnp-3500	237	23	.	.	PUNCT
fnp-3500	238	1	clinical	clinical	ADJ
fnp-3500	238	2	data	datum	NOUN
fnp-3500	238	3	were	be	AUX
fnp-3500	238	4	analysed	analyse	VERB
fnp-3500	238	5	with	with	ADP
fnp-3500	238	6	prism	prism	NOUN
fnp-3500	238	7	.	.	PUNCT
fnp-3500	239	1	results	result	NOUN
fnp-3500	239	2	:	:	PUNCT
fnp-3500	239	3	spinal	spinal	ADJ
fnp-3500	239	4	dmgs	dmgs	NOUN
fnp-3500	239	5	were	be	AUX
fnp-3500	239	6	histologically	histologically	ADV
fnp-3500	239	7	very	very	ADV
fnp-3500	239	8	heterogeneous	heterogeneous	ADJ
fnp-3500	239	9	,	,	PUNCT
fnp-3500	239	10	both	both	CCONJ
fnp-3500	239	11	with	with	ADP
fnp-3500	239	12	regard	regard	NOUN
fnp-3500	239	13	to	to	ADP
fnp-3500	239	14	different	different	ADJ
fnp-3500	239	15	areas	area	NOUN
fnp-3500	239	16	of	of	ADP
fnp-3500	239	17	single	single	ADJ
fnp-3500	239	18	tumors	tumor	NOUN
fnp-3500	239	19	as	as	ADV
fnp-3500	239	20	well	well	ADV
fnp-3500	239	21	as	as	ADP
fnp-3500	239	22	when	when	SCONJ
fnp-3500	239	23	comparing	compare	VERB
fnp-3500	239	24	different	different	ADJ
fnp-3500	239	25	tumors	tumor	NOUN
fnp-3500	239	26	.	.	PUNCT
fnp-3500	240	1	preliminary	preliminary	ADJ
fnp-3500	240	2	data	datum	NOUN
fnp-3500	240	3	suggest	suggest	VERB
fnp-3500	240	4	that	that	SCONJ
fnp-3500	240	5	there	there	PRON
fnp-3500	240	6	may	may	AUX
fnp-3500	240	7	be	be	AUX
fnp-3500	240	8	some	some	DET
fnp-3500	240	9	differences	difference	NOUN
fnp-3500	240	10	to	to	PART
fnp-3500	240	11	dmgs	dmgs	VERB
fnp-3500	240	12	of	of	ADP
fnp-3500	240	13	different	different	ADJ
fnp-3500	240	14	localisations	localisation	NOUN
fnp-3500	240	15	,	,	PUNCT
fnp-3500	240	16	e.g.	e.g.	ADV
fnp-3500	240	17	with	with	ADP
fnp-3500	240	18	regard	regard	NOUN
fnp-3500	240	19	to	to	ADP
fnp-3500	240	20	cell	cell	NOUN
fnp-3500	240	21	differentiation	differentiation	NOUN
fnp-3500	240	22	.	.	PUNCT
fnp-3500	241	1	first	first	ADJ
fnp-3500	241	2	t	t	PROPN
fnp-3500	241	3	-	-	PUNCT
fnp-3500	241	4	sne	sne	NOUN
fnp-3500	241	5	analyses	analysis	NOUN
fnp-3500	241	6	of	of	ADP
fnp-3500	241	7	dna	dna	PROPN
fnp-3500	241	8	methylation	methylation	NOUN
fnp-3500	241	9	data	datum	NOUN
fnp-3500	241	10	did	do	AUX
fnp-3500	241	11	not	not	PART
fnp-3500	241	12	indicate	indicate	VERB
fnp-3500	241	13	a	a	DET
fnp-3500	241	14	separation	separation	NOUN
fnp-3500	241	15	of	of	ADP
fnp-3500	241	16	spinal	spinal	NOUN
fnp-3500	241	17	dmgs	dmgs	NOUN
fnp-3500	241	18	from	from	ADP
fnp-3500	241	19	those	those	PRON
fnp-3500	241	20	of	of	ADP
fnp-3500	241	21	different	different	ADJ
fnp-3500	241	22	localisations	localisation	NOUN
fnp-3500	241	23	.	.	PUNCT
fnp-3500	242	1	10/11	10/11	NUM
fnp-3500	242	2	spinal	spinal	ADJ
fnp-3500	242	3	dmgs	dmgs	NOUN
fnp-3500	242	4	sequenced	sequence	VERB
fnp-3500	242	5	so	so	ADV
fnp-3500	242	6	far	far	ADV
fnp-3500	242	7	were	be	AUX
fnp-3500	242	8	h3f3a	h3f3a	PUNCT
fnp-3500	242	9	k27m	k27m	NOUN
fnp-3500	242	10	-	-	NOUN
fnp-3500	242	11	mutant	mutant	ADJ
fnp-3500	242	12	,	,	PUNCT
fnp-3500	242	13	while	while	SCONJ
fnp-3500	242	14	one	one	NUM
fnp-3500	242	15	tumor	tumor	NOUN
fnp-3500	242	16	had	have	VERB
fnp-3500	242	17	a	a	DET
fnp-3500	242	18	hist1h3b	hist1h3b	PROPN
fnp-3500	242	19	k27	k27	PROPN
fnp-3500	242	20	m	m	NOUN
fnp-3500	242	21	mutation	mutation	NOUN
fnp-3500	242	22	.	.	PUNCT
fnp-3500	243	1	mean	mean	NOUN
fnp-3500	243	2	age	age	NOUN
fnp-3500	243	3	was	be	AUX
fnp-3500	243	4	22	22	NUM
fnp-3500	243	5	years	year	NOUN
fnp-3500	243	6	.	.	PUNCT
fnp-3500	244	1	conclusion	conclusion	NOUN
fnp-3500	244	2	:	:	PUNCT
fnp-3500	244	3	first	first	ADJ
fnp-3500	244	4	analyses	analysis	NOUN
fnp-3500	244	5	suggest	suggest	VERB
fnp-3500	244	6	slight	slight	ADJ
fnp-3500	244	7	histological	histological	ADJ
fnp-3500	244	8	differences	difference	NOUN
fnp-3500	244	9	of	of	ADP
fnp-3500	244	10	spinal	spinal	ADJ
fnp-3500	244	11	dmgs	dmgs	NOUN
fnp-3500	244	12	compared	compare	VERB
fnp-3500	244	13	to	to	ADP
fnp-3500	244	14	those	those	PRON
fnp-3500	244	15	of	of	ADP
fnp-3500	244	16	other	other	ADJ
fnp-3500	244	17	localisations	localisation	NOUN
fnp-3500	244	18	.	.	PUNCT
fnp-3500	245	1	further	far	ADV
fnp-3500	245	2	histological	histological	ADJ
fnp-3500	245	3	,	,	PUNCT
fnp-3500	245	4	molecular	molecular	ADJ
fnp-3500	245	5	and	and	CCONJ
fnp-3500	245	6	clinical	clinical	ADJ
fnp-3500	245	7	analyses	analysis	NOUN
fnp-3500	245	8	are	be	AUX
fnp-3500	245	9	ongoing	ongoing	ADJ
fnp-3500	245	10	.	.	PUNCT
fnp-3500	245	11	  	  	SPACE
fnp-3500	246	1	postersession	postersession	NOUN
fnp-3500	246	2	i	i	PRON
fnp-3500	246	3	–	–	PUNCT
fnp-3500	246	4	neuroinflammation	neuroinflammation	NOUN
fnp-3500	246	5	pi-01	pi-01	NOUN
fnp-3500	246	6	free	free	ADJ
fnp-3500	246	7	neuropathol	neuropathol	NOUN
fnp-3500	246	8	2:22:29	2:22:29	NUM
fnp-3500	246	9	neurofilament	neurofilament	ADJ
fnp-3500	246	10	light	light	ADJ
fnp-3500	246	11	chains	chain	NOUN
fnp-3500	246	12	in	in	ADP
fnp-3500	246	13	serum	serum	NOUN
fnp-3500	246	14	are	be	AUX
fnp-3500	246	15	a	a	DET
fnp-3500	246	16	biomarker	biomarker	NOUN
fnp-3500	246	17	for	for	ADP
fnp-3500	246	18	the	the	DET
fnp-3500	246	19	acute	acute	ADJ
fnp-3500	246	20	axonal	axonal	ADJ
fnp-3500	246	21	damage	damage	NOUN
fnp-3500	246	22	in	in	ADP
fnp-3500	246	23	ms	ms	ADJ
fnp-3500	246	24	lesions	lesion	NOUN
fnp-3500	246	25	:	:	PUNCT
fnp-3500	246	26	a	a	DET
fnp-3500	246	27	histological	histological	ADJ
fnp-3500	246	28	-	-	PUNCT
fnp-3500	246	29	serological	serological	ADJ
fnp-3500	246	30	correlative	correlative	ADJ
fnp-3500	246	31	study	study	NOUN
fnp-3500	246	32	a.	a.	PROPN
fnp-3500	246	33	s.	s.	PROPN
fnp-3500	246	34	beutler1	beutler1	PROPN
fnp-3500	246	35	,	,	PUNCT
fnp-3500	246	36	n.	n.	PROPN
fnp-3500	246	37	kruse1	kruse1	PROPN
fnp-3500	246	38	,	,	PUNCT
fnp-3500	246	39	l.	l.	PROPN
fnp-3500	246	40	stork1	stork1	PROPN
fnp-3500	246	41	,	,	PUNCT
fnp-3500	246	42	m.	m.	NOUN
fnp-3500	246	43	gloth1	gloth1	PROPN
fnp-3500	246	44	,	,	PUNCT
fnp-3500	246	45	c.	c.	PROPN
fnp-3500	246	46	stadelmann	stadelmann	PROPN
fnp-3500	246	47	-	-	PUNCT
fnp-3500	246	48	nessler1	nessler1	NOUN
fnp-3500	246	49	,	,	PUNCT
fnp-3500	246	50	w.	w.	PROPN
fnp-3500	246	51	brück1	brück1	PROPN
fnp-3500	246	52	,	,	PUNCT
fnp-3500	246	53	i.	i.	PROPN
fnp-3500	246	54	metz1	metz1	PROPN
fnp-3500	246	55	1	1	NUM
fnp-3500	246	56	university	university	NOUN
fnp-3500	246	57	medical	medical	ADJ
fnp-3500	246	58	center	center	NOUN
fnp-3500	246	59	göttingen	göttingen	NOUN
fnp-3500	246	60	,	,	PUNCT
fnp-3500	246	61	georg	georg	NOUN
fnp-3500	246	62	-	-	PUNCT
fnp-3500	246	63	august	august	NOUN
fnp-3500	246	64	-	-	PUNCT
fnp-3500	246	65	university	university	NOUN
fnp-3500	246	66	,	,	PUNCT
fnp-3500	246	67	institute	institute	NOUN
fnp-3500	246	68	of	of	ADP
fnp-3500	246	69	neuropathology	neuropathology	NOUN
fnp-3500	246	70	,	,	PUNCT
fnp-3500	246	71	göttingen	göttingen	NOUN
fnp-3500	246	72	,	,	PUNCT
fnp-3500	246	73	germany	germany	PROPN
fnp-3500	246	74	introduction	introduction	NOUN
fnp-3500	246	75	:	:	PUNCT
fnp-3500	246	76	multiple	multiple	ADJ
fnp-3500	246	77	sclerosis	sclerosis	NOUN
fnp-3500	246	78	(	(	PUNCT
fnp-3500	246	79	ms	ms	NOUN
fnp-3500	246	80	)	)	PUNCT
fnp-3500	246	81	is	be	AUX
fnp-3500	246	82	an	an	DET
fnp-3500	246	83	inflammatory	inflammatory	ADJ
fnp-3500	246	84	demyelinating	demyelinate	VERB
fnp-3500	246	85	disease	disease	NOUN
fnp-3500	246	86	of	of	ADP
fnp-3500	246	87	the	the	DET
fnp-3500	246	88	cns	cns	NOUN
fnp-3500	246	89	,	,	PUNCT
fnp-3500	246	90	associated	associate	VERB
fnp-3500	246	91	with	with	ADP
fnp-3500	246	92	a	a	DET
fnp-3500	246	93	variable	variable	ADJ
fnp-3500	246	94	axonal	axonal	ADJ
fnp-3500	246	95	damage	damage	NOUN
fnp-3500	246	96	.	.	PUNCT
fnp-3500	247	1	the	the	DET
fnp-3500	247	2	axonal	axonal	ADJ
fnp-3500	247	3	damage	damage	NOUN
fnp-3500	247	4	is	be	AUX
fnp-3500	247	5	responsible	responsible	ADJ
fnp-3500	247	6	for	for	ADP
fnp-3500	247	7	the	the	DET
fnp-3500	247	8	irreversible	irreversible	ADJ
fnp-3500	247	9	clinical	clinical	ADJ
fnp-3500	247	10	disability	disability	NOUN
fnp-3500	247	11	,	,	PUNCT
fnp-3500	247	12	and	and	CCONJ
fnp-3500	247	13	within	within	ADP
fnp-3500	247	14	the	the	DET
fnp-3500	247	15	cns	cns	NOUN
fnp-3500	247	16	no	no	DET
fnp-3500	247	17	relevant	relevant	ADJ
fnp-3500	247	18	neuroaxonal	neuroaxonal	ADJ
fnp-3500	247	19	regeneration	regeneration	NOUN
fnp-3500	247	20	occurs	occur	VERB
fnp-3500	247	21	.	.	PUNCT
fnp-3500	248	1	thus	thus	ADV
fnp-3500	248	2	,	,	PUNCT
fnp-3500	248	3	in	in	ADP
fnp-3500	248	4	ms	ms	ADJ
fnp-3500	248	5	patients	patient	NOUN
fnp-3500	248	6	it	it	PRON
fnp-3500	248	7	is	be	AUX
fnp-3500	248	8	of	of	ADP
fnp-3500	248	9	utmost	utmost	ADJ
fnp-3500	248	10	importance	importance	NOUN
fnp-3500	248	11	to	to	PART
fnp-3500	248	12	monitor	monitor	VERB
fnp-3500	248	13	and	and	CCONJ
fnp-3500	248	14	hinder	hinder	VERB
fnp-3500	248	15	the	the	DET
fnp-3500	248	16	axonal	axonal	ADJ
fnp-3500	248	17	damage	damage	NOUN
fnp-3500	248	18	from	from	ADP
fnp-3500	248	19	the	the	DET
fnp-3500	248	20	earliest	early	ADJ
fnp-3500	248	21	stages	stage	NOUN
fnp-3500	248	22	on	on	ADP
fnp-3500	248	23	.	.	PUNCT
fnp-3500	249	1	a	a	DET
fnp-3500	249	2	promising	promising	ADJ
fnp-3500	249	3	biomarker	biomarker	NOUN
fnp-3500	249	4	are	be	AUX
fnp-3500	249	5	neurofilament	neurofilament	ADJ
fnp-3500	249	6	light	light	ADJ
fnp-3500	249	7	chains	chain	NOUN
fnp-3500	249	8	measured	measure	VERB
fnp-3500	249	9	in	in	ADP
fnp-3500	249	10	serum	serum	NOUN
fnp-3500	249	11	(	(	PUNCT
fnp-3500	249	12	snfl	snfl	NOUN
fnp-3500	249	13	)	)	PUNCT
fnp-3500	249	14	.	.	PUNCT
fnp-3500	250	1	however	however	ADV
fnp-3500	250	2	,	,	PUNCT
fnp-3500	250	3	snfl	snfl	PROPN
fnp-3500	250	4	do	do	AUX
fnp-3500	250	5	not	not	PART
fnp-3500	250	6	provide	provide	VERB
fnp-3500	250	7	any	any	DET
fnp-3500	250	8	information	information	NOUN
fnp-3500	250	9	regarding	regard	VERB
fnp-3500	250	10	the	the	DET
fnp-3500	250	11	localization	localization	NOUN
fnp-3500	250	12	of	of	ADP
fnp-3500	250	13	the	the	DET
fnp-3500	250	14	neuroaxonal	neuroaxonal	ADJ
fnp-3500	250	15	damage	damage	NOUN
fnp-3500	250	16	,	,	PUNCT
fnp-3500	250	17	and	and	CCONJ
fnp-3500	250	18	multiple	multiple	ADJ
fnp-3500	250	19	factors	factor	NOUN
fnp-3500	250	20	influence	influence	NOUN
fnp-3500	250	21	snfl	snfl	NOUN
fnp-3500	250	22	levels	level	NOUN
fnp-3500	250	23	.	.	PUNCT
fnp-3500	251	1	objectives	objective	NOUN
fnp-3500	251	2	:	:	PUNCT
fnp-3500	251	3	to	to	PART
fnp-3500	251	4	perform	perform	VERB
fnp-3500	251	5	a	a	DET
fnp-3500	251	6	histopathological	histopathological	ADJ
fnp-3500	251	7	-	-	PUNCT
fnp-3500	251	8	serological	serological	ADJ
fnp-3500	251	9	correlative	correlative	ADJ
fnp-3500	251	10	study	study	NOUN
fnp-3500	251	11	to	to	PART
fnp-3500	251	12	show	show	VERB
fnp-3500	251	13	the	the	DET
fnp-3500	251	14	pathological	pathological	ADJ
fnp-3500	251	15	correlate	correlate	NOUN
fnp-3500	251	16	of	of	ADP
fnp-3500	251	17	elevated	elevated	ADJ
fnp-3500	251	18	snfl	snfl	NOUN
fnp-3500	251	19	levels	level	NOUN
fnp-3500	251	20	in	in	ADP
fnp-3500	251	21	ms	ms	ADJ
fnp-3500	251	22	patients	patient	NOUN
fnp-3500	251	23	.	.	PUNCT
fnp-3500	252	1	patients	patient	NOUN
fnp-3500	252	2	and	and	CCONJ
fnp-3500	252	3	methods	method	NOUN
fnp-3500	252	4	:	:	PUNCT
fnp-3500	252	5	106	106	NUM
fnp-3500	252	6	ms	ms	ADJ
fnp-3500	252	7	subjects	subject	NOUN
fnp-3500	252	8	with	with	ADP
fnp-3500	252	9	biopsy	biopsy	ADJ
fnp-3500	252	10	tissue	tissue	NOUN
fnp-3500	252	11	and	and	CCONJ
fnp-3500	252	12	blood	blood	NOUN
fnp-3500	252	13	sample	sample	NOUN
fnp-3500	252	14	available	available	ADJ
fnp-3500	252	15	were	be	AUX
fnp-3500	252	16	characterized	characterize	VERB
fnp-3500	252	17	for	for	ADP
fnp-3500	252	18	their	their	PRON
fnp-3500	252	19	acute	acute	ADJ
fnp-3500	252	20	axonal	axonal	ADJ
fnp-3500	252	21	damage	damage	NOUN
fnp-3500	252	22	with	with	ADP
fnp-3500	252	23	the	the	DET
fnp-3500	252	24	anti	anti	ADJ
fnp-3500	252	25	-	-	ADJ
fnp-3500	252	26	app	app	ADJ
fnp-3500	252	27	staining	staining	NOUN
fnp-3500	252	28	and	and	CCONJ
fnp-3500	252	29	the	the	DET
fnp-3500	252	30	chronic	chronic	ADJ
fnp-3500	252	31	axonal	axonal	ADJ
fnp-3500	252	32	damage	damage	NOUN
fnp-3500	252	33	with	with	ADP
fnp-3500	252	34	the	the	DET
fnp-3500	252	35	bielschowsky	bielschowsky	NOUN
fnp-3500	252	36	silver	silver	NOUN
fnp-3500	252	37	staining	stain	VERB
fnp-3500	252	38	.	.	PUNCT
fnp-3500	253	1	results	result	NOUN
fnp-3500	253	2	were	be	AUX
fnp-3500	253	3	correlated	correlate	VERB
fnp-3500	253	4	with	with	ADP
fnp-3500	253	5	the	the	DET
fnp-3500	253	6	neurofilament	neurofilament	ADJ
fnp-3500	253	7	light	light	NOUN
fnp-3500	253	8	chain	chain	NOUN
fnp-3500	253	9	levels	level	NOUN
fnp-3500	253	10	in	in	ADP
fnp-3500	253	11	serum	serum	NOUN
fnp-3500	253	12	measured	measure	VERB
fnp-3500	253	13	with	with	ADP
fnp-3500	253	14	the	the	DET
fnp-3500	253	15	single	single	ADJ
fnp-3500	253	16	molecular	molecular	ADJ
fnp-3500	253	17	array	array	NOUN
fnp-3500	253	18	(	(	PUNCT
fnp-3500	253	19	simoa	simoa	NOUN
fnp-3500	253	20	)	)	PUNCT
fnp-3500	253	21	technique	technique	NOUN
fnp-3500	253	22	.	.	PUNCT
fnp-3500	254	1	results	result	NOUN
fnp-3500	254	2	:	:	PUNCT
fnp-3500	254	3	high	high	ADJ
fnp-3500	254	4	snfl	snfl	NOUN
fnp-3500	254	5	levels	level	NOUN
fnp-3500	254	6	were	be	AUX
fnp-3500	254	7	present	present	ADJ
fnp-3500	254	8	in	in	ADP
fnp-3500	254	9	biopsied	biopsied	ADJ
fnp-3500	254	10	ms	ms	NOUN
fnp-3500	254	11	patients	patient	NOUN
fnp-3500	254	12	(	(	PUNCT
fnp-3500	254	13	median	median	NOUN
fnp-3500	254	14	59	59	NUM
fnp-3500	254	15	pg	pg	NOUN
fnp-3500	254	16	/	/	SYM
fnp-3500	254	17	ml	ml	VERB
fnp-3500	254	18	)	)	PUNCT
fnp-3500	254	19	compared	compare	VERB
fnp-3500	254	20	to	to	ADP
fnp-3500	254	21	healthy	healthy	ADJ
fnp-3500	254	22	controls	control	NOUN
fnp-3500	254	23	(	(	PUNCT
fnp-3500	254	24	19	19	NUM
fnp-3500	254	25	pg	pg	NOUN
fnp-3500	254	26	/	/	SYM
fnp-3500	254	27	ml	ml	NOUN
fnp-3500	254	28	)	)	PUNCT
fnp-3500	254	29	,	,	PUNCT
fnp-3500	254	30	and	and	CCONJ
fnp-3500	254	31	levels	level	NOUN
fnp-3500	254	32	were	be	AUX
fnp-3500	254	33	influenced	influence	VERB
fnp-3500	254	34	by	by	ADP
fnp-3500	254	35	the	the	DET
fnp-3500	254	36	age	age	NOUN
fnp-3500	254	37	of	of	ADP
fnp-3500	254	38	patients	patient	NOUN
fnp-3500	254	39	,	,	PUNCT
fnp-3500	254	40	relapses	relapse	VERB
fnp-3500	254	41	prior	prior	ADV
fnp-3500	254	42	blood	blood	NOUN
fnp-3500	254	43	sampling	sample	VERB
fnp-3500	254	44	as	as	ADV
fnp-3500	254	45	well	well	ADV
fnp-3500	254	46	as	as	ADP
fnp-3500	254	47	the	the	DET
fnp-3500	254	48	time	time	NOUN
fnp-3500	254	49	interval	interval	NOUN
fnp-3500	254	50	after	after	ADP
fnp-3500	254	51	biopsy	biopsy	NOUN
fnp-3500	254	52	.	.	PUNCT
fnp-3500	255	1	correlating	correlate	VERB
fnp-3500	255	2	histological	histological	ADJ
fnp-3500	255	3	parameters	parameter	NOUN
fnp-3500	255	4	with	with	ADP
fnp-3500	255	5	snfl	snfl	NOUN
fnp-3500	255	6	,	,	PUNCT
fnp-3500	255	7	multiple	multiple	ADJ
fnp-3500	255	8	regression	regression	NOUN
fnp-3500	255	9	analyses	analysis	NOUN
fnp-3500	255	10	showed	show	VERB
fnp-3500	255	11	that	that	SCONJ
fnp-3500	255	12	the	the	DET
fnp-3500	255	13	acute	acute	ADJ
fnp-3500	255	14	axonal	axonal	ADJ
fnp-3500	255	15	damage	damage	NOUN
fnp-3500	255	16	within	within	ADP
fnp-3500	255	17	early	early	ADJ
fnp-3500	255	18	active	active	ADJ
fnp-3500	255	19	ms	ms	ADJ
fnp-3500	255	20	lesions	lesion	NOUN
fnp-3500	255	21	significantly	significantly	ADV
fnp-3500	255	22	contributed	contribute	VERB
fnp-3500	255	23	to	to	ADP
fnp-3500	255	24	the	the	DET
fnp-3500	255	25	snfl	snfl	NOUN
fnp-3500	255	26	(	(	PUNCT
fnp-3500	255	27	p<0.01	p<0.01	PROPN
fnp-3500	255	28	)	)	PUNCT
fnp-3500	255	29	,	,	PUNCT
fnp-3500	255	30	but	but	CCONJ
fnp-3500	255	31	not	not	PART
fnp-3500	255	32	the	the	DET
fnp-3500	255	33	axonal	axonal	ADJ
fnp-3500	255	34	density	density	NOUN
fnp-3500	255	35	.	.	PUNCT
fnp-3500	256	1	importantly	importantly	ADV
fnp-3500	256	2	,	,	PUNCT
fnp-3500	256	3	snfl	snfl	PROPN
fnp-3500	256	4	correlated	correlate	VERB
fnp-3500	256	5	with	with	ADP
fnp-3500	256	6	the	the	DET
fnp-3500	256	7	clinical	clinical	ADJ
fnp-3500	256	8	disability	disability	NOUN
fnp-3500	256	9	at	at	ADP
fnp-3500	256	10	biopsy	biopsy	NOUN
fnp-3500	256	11	as	as	ADV
fnp-3500	256	12	well	well	ADV
fnp-3500	256	13	as	as	ADP
fnp-3500	256	14	at	at	ADP
fnp-3500	256	15	last	last	ADJ
fnp-3500	256	16	follow	follow	NOUN
fnp-3500	256	17	-	-	PUNCT
fnp-3500	256	18	up	up	NOUN
fnp-3500	256	19	.	.	PUNCT
fnp-3500	257	1	conclusion	conclusion	NOUN
fnp-3500	257	2	:	:	PUNCT
fnp-3500	257	3	snfl	snfl	NOUN
fnp-3500	257	4	mirror	mirror	VERB
fnp-3500	257	5	the	the	DET
fnp-3500	257	6	acute	acute	ADJ
fnp-3500	257	7	axonal	axonal	ADJ
fnp-3500	257	8	damage	damage	NOUN
fnp-3500	257	9	in	in	ADP
fnp-3500	257	10	early	early	ADJ
fnp-3500	257	11	ms	ms	ADJ
fnp-3500	257	12	lesions	lesion	NOUN
fnp-3500	257	13	as	as	SCONJ
fnp-3500	257	14	shown	show	VERB
fnp-3500	257	15	by	by	ADP
fnp-3500	257	16	histology	histology	NOUN
fnp-3500	257	17	,	,	PUNCT
fnp-3500	257	18	and	and	CCONJ
fnp-3500	257	19	correlate	correlate	VERB
fnp-3500	257	20	with	with	ADP
fnp-3500	257	21	the	the	DET
fnp-3500	257	22	clinical	clinical	ADJ
fnp-3500	257	23	disability	disability	NOUN
fnp-3500	257	24	of	of	ADP
fnp-3500	257	25	patients	patient	NOUN
fnp-3500	257	26	.	.	PUNCT
fnp-3500	258	1	they	they	PRON
fnp-3500	258	2	are	be	AUX
fnp-3500	258	3	thus	thus	ADV
fnp-3500	258	4	a	a	DET
fnp-3500	258	5	promising	promising	ADJ
fnp-3500	258	6	biomarker	biomarker	NOUN
fnp-3500	258	7	to	to	PART
fnp-3500	258	8	monitor	monitor	VERB
fnp-3500	258	9	the	the	DET
fnp-3500	258	10	axonal	axonal	ADJ
fnp-3500	258	11	damage	damage	NOUN
fnp-3500	258	12	ex	ex	X
fnp-3500	258	13	vivo	vivo	NOUN
fnp-3500	258	14	in	in	ADP
fnp-3500	258	15	ms	ms	ADJ
fnp-3500	258	16	patients	patient	NOUN
fnp-3500	258	17	.	.	PUNCT
fnp-3500	259	1	this	this	DET
fnp-3500	259	2	study	study	NOUN
fnp-3500	259	3	was	be	AUX
fnp-3500	259	4	sponsored	sponsor	VERB
fnp-3500	259	5	by	by	ADP
fnp-3500	259	6	novartis	novartis	PROPN
fnp-3500	259	7	pharma	pharma	PROPN
fnp-3500	259	8	gmbh	gmbh	PROPN
fnp-3500	259	9	.	.	PUNCT
fnp-3500	259	10	  	  	SPACE
fnp-3500	260	1	pi-02	pi-02	ADV
fnp-3500	260	2	free	free	ADJ
fnp-3500	260	3	neuropathol	neuropathol	NOUN
fnp-3500	260	4	2:22:30	2:22:30	NUM
fnp-3500	260	5	mgmt	mgmt	ADJ
fnp-3500	260	6	-	-	PUNCT
fnp-3500	260	7	promoter	promoter	NOUN
fnp-3500	260	8	methylation	methylation	NOUN
fnp-3500	260	9	in	in	ADP
fnp-3500	260	10	non	non	ADJ
fnp-3500	260	11	-	-	ADJ
fnp-3500	260	12	neoplastic	neoplastic	ADJ
fnp-3500	260	13	diseases	disease	NOUN
fnp-3500	260	14	of	of	ADP
fnp-3500	260	15	the	the	DET
fnp-3500	260	16	central	central	ADJ
fnp-3500	260	17	nervous	nervous	ADJ
fnp-3500	260	18	system	system	NOUN
fnp-3500	260	19	s.	s.	PROPN
fnp-3500	260	20	teuber	teuber	PROPN
fnp-3500	260	21	-	-	PUNCT
fnp-3500	260	22	hanselmann1	hanselmann1	PROPN
fnp-3500	260	23	,	,	PUNCT
fnp-3500	260	24	k.	k.	PROPN
fnp-3500	260	25	worm2	worm2	PROPN
fnp-3500	260	26	,	,	PUNCT
fnp-3500	260	27	a.	a.	NOUN
fnp-3500	260	28	junker1	junker1	NOUN
fnp-3500	260	29	1	1	NUM
fnp-3500	260	30	universitätsklinikum	universitätsklinikum	NOUN
fnp-3500	260	31	essen	essen	NOUN
fnp-3500	260	32	,	,	PUNCT
fnp-3500	260	33	institut	institut	PROPN
fnp-3500	260	34	für	für	PROPN
fnp-3500	260	35	neuropathologie	neuropathologie	PROPN
fnp-3500	260	36	,	,	PUNCT
fnp-3500	260	37	essen	essen	PROPN
fnp-3500	260	38	,	,	PUNCT
fnp-3500	260	39	germany	germany	PROPN
fnp-3500	260	40	2	2	NUM
fnp-3500	260	41	universitätsklinikum	universitätsklinikum	NOUN
fnp-3500	260	42	essen	essen	NOUN
fnp-3500	260	43	,	,	PUNCT
fnp-3500	260	44	institut	institut	PROPN
fnp-3500	260	45	für	für	PROPN
fnp-3500	260	46	pathologie	pathologie	PROPN
fnp-3500	260	47	,	,	PUNCT
fnp-3500	260	48	essen	essen	PROPN
fnp-3500	260	49	,	,	PUNCT
fnp-3500	260	50	germany	germany	PROPN
fnp-3500	260	51	introduction	introduction	NOUN
fnp-3500	260	52	:	:	PUNCT
fnp-3500	260	53	o6	o6	ADJ
fnp-3500	260	54	-	-	PUNCT
fnp-3500	260	55	methylguanine	methylguanine	NOUN
fnp-3500	260	56	-	-	PUNCT
fnp-3500	260	57	dna	dna	NOUN
fnp-3500	260	58	-	-	PUNCT
fnp-3500	260	59	methyltransferase	methyltransferase	NOUN
fnp-3500	260	60	(	(	PUNCT
fnp-3500	260	61	mgmt	mgmt	NOUN
fnp-3500	260	62	)	)	PUNCT
fnp-3500	260	63	plays	play	VERB
fnp-3500	260	64	a	a	DET
fnp-3500	260	65	pivotal	pivotal	ADJ
fnp-3500	260	66	role	role	NOUN
fnp-3500	260	67	in	in	ADP
fnp-3500	260	68	cellular	cellular	ADJ
fnp-3500	260	69	defense	defense	NOUN
fnp-3500	260	70	by	by	ADP
fnp-3500	260	71	repairing	repair	VERB
fnp-3500	260	72	alkylated	alkylated	ADJ
fnp-3500	260	73	dna	dna	PROPN
fnp-3500	260	74	.	.	PUNCT
fnp-3500	261	1	hypermethylation	hypermethylation	NOUN
fnp-3500	261	2	of	of	ADP
fnp-3500	261	3	the	the	DET
fnp-3500	261	4	mgmt	mgmt	PROPN
fnp-3500	261	5	promoter	promoter	NOUN
fnp-3500	261	6	region	region	NOUN
fnp-3500	261	7	results	result	VERB
fnp-3500	261	8	in	in	ADP
fnp-3500	261	9	gene	gene	NOUN
fnp-3500	261	10	silencing	silencing	NOUN
fnp-3500	261	11	,	,	PUNCT
fnp-3500	261	12	an	an	DET
fnp-3500	261	13	effect	effect	NOUN
fnp-3500	261	14	seen	see	VERB
fnp-3500	261	15	in	in	ADP
fnp-3500	261	16	various	various	ADJ
fnp-3500	261	17	tumors	tumor	NOUN
fnp-3500	261	18	,	,	PUNCT
fnp-3500	261	19	like	like	ADP
fnp-3500	261	20	gliomas	glioma	NOUN
fnp-3500	261	21	.	.	PUNCT
fnp-3500	262	1	mgmt	mgmt	PROPN
fnp-3500	262	2	hypermethylation	hypermethylation	NOUN
fnp-3500	262	3	was	be	AUX
fnp-3500	262	4	postulated	postulate	VERB
fnp-3500	262	5	to	to	PART
fnp-3500	262	6	be	be	AUX
fnp-3500	262	7	attributed	attribute	VERB
fnp-3500	262	8	to	to	ADP
fnp-3500	262	9	cancers	cancer	NOUN
fnp-3500	262	10	or	or	CCONJ
fnp-3500	262	11	to	to	ADP
fnp-3500	262	12	malignant	malignant	ADJ
fnp-3500	262	13	transformation	transformation	NOUN
fnp-3500	262	14	of	of	ADP
fnp-3500	262	15	precancerous	precancerous	ADJ
fnp-3500	262	16	lesions	lesion	NOUN
fnp-3500	262	17	and	and	CCONJ
fnp-3500	262	18	that	that	SCONJ
fnp-3500	262	19	consequently	consequently	ADV
fnp-3500	262	20	it	it	PRON
fnp-3500	262	21	could	could	AUX
fnp-3500	262	22	be	be	AUX
fnp-3500	262	23	used	use	VERB
fnp-3500	262	24	as	as	ADP
fnp-3500	262	25	a	a	DET
fnp-3500	262	26	tumor	tumor	NOUN
fnp-3500	262	27	biomarker	biomarker	NOUN
fnp-3500	262	28	.	.	PUNCT
fnp-3500	263	1	but	but	CCONJ
fnp-3500	263	2	while	while	SCONJ
fnp-3500	263	3	mgmt	mgmt	PROPN
fnp-3500	263	4	hypermethylation	hypermethylation	NOUN
fnp-3500	263	5	was	be	AUX
fnp-3500	263	6	also	also	ADV
fnp-3500	263	7	detected	detect	VERB
fnp-3500	263	8	in	in	ADP
fnp-3500	263	9	various	various	ADJ
fnp-3500	263	10	peripheral	peripheral	ADJ
fnp-3500	263	11	inflammatory	inflammatory	ADJ
fnp-3500	263	12	diseases	disease	NOUN
fnp-3500	263	13	,	,	PUNCT
fnp-3500	263	14	it	it	PRON
fnp-3500	263	15	has	have	AUX
fnp-3500	263	16	not	not	PART
fnp-3500	263	17	yet	yet	ADV
fnp-3500	263	18	been	be	AUX
fnp-3500	263	19	investigated	investigate	VERB
fnp-3500	263	20	in	in	ADP
fnp-3500	263	21	non	non	ADJ
fnp-3500	263	22	-	-	ADJ
fnp-3500	263	23	neoplastic	neoplastic	ADJ
fnp-3500	263	24	cns	cns	NOUN
fnp-3500	263	25	diseases	disease	NOUN
fnp-3500	263	26	.	.	PUNCT
fnp-3500	264	1	objectives	objective	NOUN
fnp-3500	264	2	:	:	PUNCT
fnp-3500	264	3	to	to	PART
fnp-3500	264	4	investigate	investigate	VERB
fnp-3500	264	5	mgmt	mgmt	NOUN
fnp-3500	264	6	promoter	promoter	NOUN
fnp-3500	264	7	methylation	methylation	NOUN
fnp-3500	264	8	levels	level	NOUN
fnp-3500	264	9	in	in	ADP
fnp-3500	264	10	various	various	ADJ
fnp-3500	264	11	non	non	ADJ
fnp-3500	264	12	-	-	ADJ
fnp-3500	264	13	neoplastic	neoplastic	ADJ
fnp-3500	264	14	cns	cns	NOUN
fnp-3500	264	15	diseases	disease	NOUN
fnp-3500	264	16	.	.	PUNCT
fnp-3500	265	1	methods	method	NOUN
fnp-3500	265	2	:	:	PUNCT
fnp-3500	265	3	mgmt	mgmt	NOUN
fnp-3500	265	4	promoter	promoter	NOUN
fnp-3500	265	5	methylation	methylation	NOUN
fnp-3500	265	6	and	and	CCONJ
fnp-3500	265	7	expression	expression	NOUN
fnp-3500	265	8	levels	level	NOUN
fnp-3500	265	9	of	of	ADP
fnp-3500	265	10	dna	dna	PROPN
fnp-3500	265	11	demethylases	demethylase	VERB
fnp-3500	265	12	tet1	tet1	NOUN
fnp-3500	265	13	and	and	CCONJ
fnp-3500	265	14	tet2	tet2	NOUN
fnp-3500	265	15	were	be	AUX
fnp-3500	265	16	investigated	investigate	VERB
fnp-3500	265	17	via	via	ADP
fnp-3500	265	18	pyrosequencing	pyrosequencing	NOUN
fnp-3500	265	19	and	and	CCONJ
fnp-3500	265	20	immunohistochemistry	immunohistochemistry	NOUN
fnp-3500	265	21	on	on	ADP
fnp-3500	265	22	human	human	ADJ
fnp-3500	265	23	autopsy	autopsy	ADJ
fnp-3500	265	24	or	or	CCONJ
fnp-3500	265	25	biopsy	biopsy	NOUN
fnp-3500	265	26	ffpe	ffpe	ADJ
fnp-3500	265	27	tissue	tissue	NOUN
fnp-3500	265	28	samples	sample	NOUN
fnp-3500	265	29	with	with	ADP
fnp-3500	265	30	pml	pml	PROPN
fnp-3500	265	31	(	(	PUNCT
fnp-3500	265	32	10	10	NUM
fnp-3500	265	33	)	)	PUNCT
fnp-3500	265	34	,	,	PUNCT
fnp-3500	265	35	ms	ms	PROPN
fnp-3500	265	36	(	(	PUNCT
fnp-3500	265	37	28	28	NUM
fnp-3500	265	38	)	)	PUNCT
fnp-3500	265	39	,	,	PUNCT
fnp-3500	265	40	toxoplasmosis	toxoplasmosis	NOUN
fnp-3500	265	41	(	(	PUNCT
fnp-3500	265	42	6	6	NUM
fnp-3500	265	43	)	)	PUNCT
fnp-3500	265	44	,	,	PUNCT
fnp-3500	265	45	cmv	cmv	NOUN
fnp-3500	265	46	(	(	PUNCT
fnp-3500	265	47	1	1	NUM
fnp-3500	265	48	)	)	PUNCT
fnp-3500	265	49	,	,	PUNCT
fnp-3500	265	50	hsv1	hsv1	PROPN
fnp-3500	265	51	(	(	PUNCT
fnp-3500	265	52	1	1	NUM
fnp-3500	265	53	)	)	PUNCT
fnp-3500	265	54	or	or	CCONJ
fnp-3500	265	55	hiv	hiv	PROPN
fnp-3500	265	56	(	(	PUNCT
fnp-3500	265	57	2	2	NUM
fnp-3500	265	58	)	)	PUNCT
fnp-3500	265	59	infection	infection	NOUN
fnp-3500	265	60	,	,	PUNCT
fnp-3500	265	61	mycotic	mycotic	ADJ
fnp-3500	265	62	encephalitis	encephalitis	NOUN
fnp-3500	265	63	(	(	PUNCT
fnp-3500	265	64	4	4	NUM
fnp-3500	265	65	)	)	PUNCT
fnp-3500	265	66	,	,	PUNCT
fnp-3500	265	67	brain	brain	NOUN
fnp-3500	265	68	abscesses	abscess	NOUN
fnp-3500	265	69	(	(	PUNCT
fnp-3500	265	70	3	3	NUM
fnp-3500	265	71	)	)	PUNCT
fnp-3500	265	72	,	,	PUNCT
fnp-3500	265	73	central	central	ADJ
fnp-3500	265	74	pontine	pontine	ADJ
fnp-3500	265	75	/	/	SYM
fnp-3500	265	76	extrapontine	extrapontine	NOUN
fnp-3500	265	77	myelinolysis	myelinolysis	NOUN
fnp-3500	265	78	(	(	PUNCT
fnp-3500	265	79	cpm	cpm	NOUN
fnp-3500	265	80	/	/	SYM
fnp-3500	265	81	epm	epm	NOUN
fnp-3500	265	82	)	)	PUNCT
fnp-3500	265	83	(	(	PUNCT
fnp-3500	265	84	8)	8)	NUM
fnp-3500	265	85	,	,	PUNCT
fnp-3500	265	86	wallerian	wallerian	ADJ
fnp-3500	265	87	degeneration	degeneration	NOUN
fnp-3500	265	88	(	(	PUNCT
fnp-3500	265	89	3	3	NUM
fnp-3500	265	90	)	)	PUNCT
fnp-3500	265	91	and	and	CCONJ
fnp-3500	265	92	controls	control	NOUN
fnp-3500	265	93	without	without	ADP
fnp-3500	265	94	cns	cns	PROPN
fnp-3500	265	95	pathologies	pathology	NOUN
fnp-3500	265	96	(	(	PUNCT
fnp-3500	265	97	8)	8)	NUM
fnp-3500	265	98	.	.	PUNCT
fnp-3500	265	99	results	result	NOUN
fnp-3500	265	100	:	:	PUNCT
fnp-3500	265	101	slight	slight	ADJ
fnp-3500	265	102	mgmt	mgmt	PROPN
fnp-3500	265	103	hypermethylation	hypermethylation	NOUN
fnp-3500	265	104	was	be	AUX
fnp-3500	265	105	seen	see	VERB
fnp-3500	265	106	in	in	ADP
fnp-3500	265	107	non	non	ADJ
fnp-3500	265	108	-	-	ADJ
fnp-3500	265	109	neoplastic	neoplastic	ADJ
fnp-3500	265	110	cns	cns	NOUN
fnp-3500	265	111	diseases	disease	NOUN
fnp-3500	265	112	,	,	PUNCT
fnp-3500	265	113	all	all	PRON
fnp-3500	265	114	of	of	ADP
fnp-3500	265	115	which	which	PRON
fnp-3500	265	116	were	be	AUX
fnp-3500	265	117	associated	associate	VERB
fnp-3500	265	118	with	with	ADP
fnp-3500	265	119	damaged	damage	VERB
fnp-3500	265	120	myelin	myelin	ADJ
fnp-3500	265	121	sheaths	sheath	NOUN
fnp-3500	265	122	,	,	PUNCT
fnp-3500	265	123	i.e.	i.e.	X
fnp-3500	265	124	inflammatory	inflammatory	ADJ
fnp-3500	265	125	and	and	CCONJ
fnp-3500	265	126	demyelinating	demyelinate	VERB
fnp-3500	265	127	(	(	PUNCT
fnp-3500	265	128	ms	ms	NOUN
fnp-3500	265	129	and	and	CCONJ
fnp-3500	265	130	pml	pml	NOUN
fnp-3500	265	131	)	)	PUNCT
fnp-3500	265	132	,	,	PUNCT
fnp-3500	265	133	as	as	ADV
fnp-3500	265	134	well	well	ADV
fnp-3500	265	135	as	as	ADP
fnp-3500	265	136	non	non	ADJ
fnp-3500	265	137	-	-	ADJ
fnp-3500	265	138	inflammatory	inflammatory	ADJ
fnp-3500	265	139	metabolic	metabolic	NOUN
fnp-3500	265	140	or	or	CCONJ
fnp-3500	265	141	degenerative	degenerative	ADJ
fnp-3500	265	142	cns	cns	NOUN
fnp-3500	265	143	diseases	disease	NOUN
fnp-3500	265	144	(	(	PUNCT
fnp-3500	265	145	cpm	cpm	PROPN
fnp-3500	265	146	/	/	SYM
fnp-3500	265	147	epm	epm	PROPN
fnp-3500	265	148	,	,	PUNCT
fnp-3500	265	149	wallerian	wallerian	NOUN
fnp-3500	265	150	degeneration	degeneration	NOUN
fnp-3500	265	151	)	)	PUNCT
fnp-3500	265	152	,	,	PUNCT
fnp-3500	265	153	while	while	SCONJ
fnp-3500	265	154	there	there	PRON
fnp-3500	265	155	were	be	VERB
fnp-3500	265	156	no	no	DET
fnp-3500	265	157	associations	association	NOUN
fnp-3500	265	158	with	with	ADP
fnp-3500	265	159	infectious	infectious	ADJ
fnp-3500	265	160	non	non	ADJ
fnp-3500	265	161	-	-	ADJ
fnp-3500	265	162	demyelinating	demyelinating	ADJ
fnp-3500	265	163	diseases	disease	NOUN
fnp-3500	265	164	or	or	CCONJ
fnp-3500	265	165	distinct	distinct	ADJ
fnp-3500	265	166	pathogens	pathogen	NOUN
fnp-3500	265	167	.	.	PUNCT
fnp-3500	266	1	reduced	reduce	VERB
fnp-3500	266	2	expression	expression	NOUN
fnp-3500	266	3	levels	level	NOUN
fnp-3500	266	4	of	of	ADP
fnp-3500	266	5	tet1	tet1	NOUN
fnp-3500	266	6	could	could	AUX
fnp-3500	266	7	possibly	possibly	ADV
fnp-3500	266	8	be	be	AUX
fnp-3500	266	9	the	the	DET
fnp-3500	266	10	cause	cause	NOUN
fnp-3500	266	11	for	for	ADP
fnp-3500	266	12	mgmt	mgmt	NOUN
fnp-3500	266	13	hypermethylation	hypermethylation	NOUN
fnp-3500	266	14	.	.	PUNCT
fnp-3500	267	1	conclusion	conclusion	NOUN
fnp-3500	267	2	:	:	PUNCT
fnp-3500	267	3	mgmt	mgmt	NOUN
fnp-3500	267	4	hypermethylation	hypermethylation	NOUN
fnp-3500	267	5	is	be	AUX
fnp-3500	267	6	not	not	PART
fnp-3500	267	7	restricted	restrict	VERB
fnp-3500	267	8	to	to	ADP
fnp-3500	267	9	neoplastic	neoplastic	ADJ
fnp-3500	267	10	or	or	CCONJ
fnp-3500	267	11	infectious	infectious	ADJ
fnp-3500	267	12	diseases	disease	NOUN
fnp-3500	267	13	but	but	CCONJ
fnp-3500	267	14	occurs	occur	VERB
fnp-3500	267	15	in	in	ADP
fnp-3500	267	16	chronic	chronic	ADJ
fnp-3500	267	17	cns	cns	NOUN
fnp-3500	267	18	diseases	disease	NOUN
fnp-3500	267	19	that	that	PRON
fnp-3500	267	20	lead	lead	VERB
fnp-3500	267	21	to	to	ADP
fnp-3500	267	22	damage	damage	NOUN
fnp-3500	267	23	of	of	ADP
fnp-3500	267	24	the	the	DET
fnp-3500	267	25	myelin	myelin	NOUN
fnp-3500	267	26	sheath	sheath	NOUN
fnp-3500	267	27	in	in	ADP
fnp-3500	267	28	various	various	ADJ
fnp-3500	267	29	ways	way	NOUN
fnp-3500	267	30	.	.	PUNCT
fnp-3500	268	1	while	while	SCONJ
fnp-3500	268	2	this	this	PRON
fnp-3500	268	3	gives	give	VERB
fnp-3500	268	4	new	new	ADJ
fnp-3500	268	5	insights	insight	NOUN
fnp-3500	268	6	into	into	ADP
fnp-3500	268	7	epigenetic	epigenetic	ADJ
fnp-3500	268	8	and	and	CCONJ
fnp-3500	268	9	pathophysiological	pathophysiological	ADJ
fnp-3500	268	10	processes	process	NOUN
fnp-3500	268	11	involved	involve	VERB
fnp-3500	268	12	in	in	ADP
fnp-3500	268	13	de-/remyelination	de-/remyelination	PROPN
fnp-3500	268	14	,	,	PUNCT
fnp-3500	268	15	it	it	PRON
fnp-3500	268	16	also	also	ADV
fnp-3500	268	17	reduces	reduce	VERB
fnp-3500	268	18	the	the	DET
fnp-3500	268	19	specificity	specificity	NOUN
fnp-3500	268	20	of	of	ADP
fnp-3500	268	21	mgmt	mgmt	PROPN
fnp-3500	268	22	hypermethylation	hypermethylation	NOUN
fnp-3500	268	23	as	as	ADP
fnp-3500	268	24	a	a	DET
fnp-3500	268	25	tumor	tumor	NOUN
fnp-3500	268	26	biomarker	biomarker	NOUN
fnp-3500	268	27	.	.	PUNCT
fnp-3500	268	28	  	  	SPACE
fnp-3500	269	1	pi-03	pi-03	CCONJ
fnp-3500	269	2	free	free	ADJ
fnp-3500	269	3	neuropathol	neuropathol	NOUN
fnp-3500	269	4	2:22:31	2:22:31	NUM
fnp-3500	269	5	chronic	chronic	ADJ
fnp-3500	269	6	retrotransposon	retrotransposon	NOUN
fnp-3500	269	7	expression	expression	NOUN
fnp-3500	269	8	in	in	ADP
fnp-3500	269	9	mouse	mouse	NOUN
fnp-3500	269	10	glial	glial	ADJ
fnp-3500	269	11	cells	cell	NOUN
fnp-3500	269	12	is	be	AUX
fnp-3500	269	13	associated	associate	VERB
fnp-3500	269	14	with	with	ADP
fnp-3500	269	15	spatial	spatial	ADJ
fnp-3500	269	16	learning	learn	VERB
fnp-3500	269	17	deficits	deficit	NOUN
fnp-3500	269	18	without	without	ADP
fnp-3500	269	19	an	an	DET
fnp-3500	269	20	overt	overt	ADJ
fnp-3500	269	21	inflammatory	inflammatory	ADJ
fnp-3500	269	22	response	response	NOUN
fnp-3500	269	23	r.	r.	PROPN
fnp-3500	269	24	sankowski1	sankowski1	PROPN
fnp-3500	269	25	,	,	PUNCT
fnp-3500	269	26	g.	g.	PROPN
fnp-3500	269	27	monaco1	monaco1	PROPN
fnp-3500	269	28	,	,	PUNCT
fnp-3500	269	29	m.	m.	NOUN
fnp-3500	269	30	prinz1	prinz1	NOUN
fnp-3500	269	31	1	1	NUM
fnp-3500	269	32	universitätsklinikum	universitätsklinikum	NOUN
fnp-3500	269	33	freiburg	freiburg	PROPN
fnp-3500	269	34	,	,	PUNCT
fnp-3500	269	35	institut	institut	PROPN
fnp-3500	269	36	für	für	PROPN
fnp-3500	269	37	neuropathologie	neuropathologie	PROPN
fnp-3500	269	38	,	,	PUNCT
fnp-3500	269	39	freiburg	freiburg	PROPN
fnp-3500	269	40	i.	i.	PROPN
fnp-3500	269	41	br	br	PROPN
fnp-3500	269	42	.	.	PROPN
fnp-3500	269	43	,	,	PUNCT
fnp-3500	270	1	germany	germany	PROPN
fnp-3500	270	2	introduction	introduction	NOUN
fnp-3500	270	3	:	:	PUNCT
fnp-3500	270	4	retrotransposons	retrotransposon	NOUN
fnp-3500	270	5	are	be	AUX
fnp-3500	270	6	mobile	mobile	ADJ
fnp-3500	270	7	genomic	genomic	NOUN
fnp-3500	270	8	elements	element	NOUN
fnp-3500	270	9	comprising	comprise	VERB
fnp-3500	270	10	approximately	approximately	ADV
fnp-3500	270	11	40	40	NUM
fnp-3500	270	12	percent	percent	NOUN
fnp-3500	270	13	of	of	ADP
fnp-3500	270	14	the	the	DET
fnp-3500	270	15	human	human	ADJ
fnp-3500	270	16	and	and	CCONJ
fnp-3500	270	17	mouse	mouse	NOUN
fnp-3500	270	18	genomes	genome	NOUN
fnp-3500	270	19	.	.	PUNCT
fnp-3500	271	1	activation	activation	NOUN
fnp-3500	271	2	of	of	ADP
fnp-3500	271	3	retrotransposons	retrotransposon	NOUN
fnp-3500	271	4	has	have	AUX
fnp-3500	271	5	been	be	AUX
fnp-3500	271	6	associated	associate	VERB
fnp-3500	271	7	with	with	ADP
fnp-3500	271	8	an	an	DET
fnp-3500	271	9	inflammatory	inflammatory	ADJ
fnp-3500	271	10	response	response	NOUN
fnp-3500	271	11	in	in	ADP
fnp-3500	271	12	the	the	DET
fnp-3500	271	13	brain	brain	NOUN
fnp-3500	271	14	and	and	CCONJ
fnp-3500	271	15	peripheral	peripheral	ADJ
fnp-3500	271	16	tissues	tissue	NOUN
fnp-3500	271	17	.	.	PUNCT
fnp-3500	272	1	we	we	PRON
fnp-3500	272	2	have	have	AUX
fnp-3500	272	3	previously	previously	ADV
fnp-3500	272	4	shown	show	VERB
fnp-3500	272	5	that	that	SCONJ
fnp-3500	272	6	chronic	chronic	ADJ
fnp-3500	272	7	retrotransposon	retrotransposon	NOUN
fnp-3500	272	8	activation	activation	NOUN
fnp-3500	272	9	in	in	ADP
fnp-3500	272	10	b	b	PROPN
fnp-3500	272	11	cell	cell	NOUN
fnp-3500	272	12	deficient	deficient	ADJ
fnp-3500	272	13	mice	mouse	NOUN
fnp-3500	272	14	was	be	AUX
fnp-3500	272	15	associated	associate	VERB
fnp-3500	272	16	with	with	ADP
fnp-3500	272	17	astrogliosis	astrogliosis	NOUN
fnp-3500	272	18	and	and	CCONJ
fnp-3500	272	19	spatial	spatial	ADJ
fnp-3500	272	20	learning	learn	VERB
fnp-3500	272	21	deficits	deficit	NOUN
fnp-3500	272	22	.	.	PUNCT
fnp-3500	273	1	objective	objective	NOUN
fnp-3500	273	2	:	:	PUNCT
fnp-3500	273	3	we	we	PRON
fnp-3500	273	4	were	be	AUX
fnp-3500	273	5	wondering	wonder	VERB
fnp-3500	273	6	about	about	ADP
fnp-3500	273	7	cell	cell	NOUN
fnp-3500	273	8	-	-	PUNCT
fnp-3500	273	9	type	type	NOUN
fnp-3500	273	10	dependent	dependent	ADJ
fnp-3500	273	11	retrotransposon	retrotransposon	NOUN
fnp-3500	273	12	expression	expression	NOUN
fnp-3500	273	13	in	in	ADP
fnp-3500	273	14	the	the	DET
fnp-3500	273	15	b	b	PROPN
fnp-3500	273	16	cell	cell	NOUN
fnp-3500	273	17	deficient	deficient	ADJ
fnp-3500	273	18	mouse	mouse	NOUN
fnp-3500	273	19	model	model	NOUN
fnp-3500	273	20	of	of	ADP
fnp-3500	273	21	constitutive	constitutive	ADJ
fnp-3500	273	22	retrotransposon	retrotransposon	NOUN
fnp-3500	273	23	activation	activation	NOUN
fnp-3500	273	24	.	.	PUNCT
fnp-3500	274	1	materials	material	NOUN
fnp-3500	274	2	&	&	CCONJ
fnp-3500	274	3	methods	method	NOUN
fnp-3500	274	4	:	:	PUNCT
fnp-3500	274	5	here	here	ADV
fnp-3500	274	6	,	,	PUNCT
fnp-3500	274	7	we	we	PRON
fnp-3500	274	8	have	have	AUX
fnp-3500	274	9	utilised	utilise	VERB
fnp-3500	274	10	single	single	ADJ
fnp-3500	274	11	-	-	PUNCT
fnp-3500	274	12	nucleus	nucleus	NOUN
fnp-3500	274	13	and	and	CCONJ
fnp-3500	274	14	single	single	ADJ
fnp-3500	274	15	-	-	PUNCT
fnp-3500	274	16	cell	cell	NOUN
fnp-3500	274	17	rna	rna	NOUN
fnp-3500	274	18	-	-	PUNCT
fnp-3500	274	19	sequencing	sequence	VERB
fnp-3500	274	20	to	to	PART
fnp-3500	274	21	profile	profile	VERB
fnp-3500	274	22	the	the	DET
fnp-3500	274	23	expression	expression	NOUN
fnp-3500	274	24	of	of	ADP
fnp-3500	274	25	retrotransposons	retrotransposon	NOUN
fnp-3500	274	26	in	in	ADP
fnp-3500	274	27	hippocampi	hippocampi	ADJ
fnp-3500	274	28	and	and	CCONJ
fnp-3500	274	29	cortices	cortex	NOUN
fnp-3500	274	30	of	of	ADP
fnp-3500	274	31	b	b	NOUN
fnp-3500	274	32	cell	cell	NOUN
fnp-3500	274	33	deficient	deficient	ADJ
fnp-3500	274	34	mice	mouse	NOUN
fnp-3500	274	35	.	.	PUNCT
fnp-3500	275	1	results	result	NOUN
fnp-3500	275	2	:	:	PUNCT
fnp-3500	275	3	we	we	PRON
fnp-3500	275	4	could	could	AUX
fnp-3500	275	5	identify	identify	VERB
fnp-3500	275	6	increased	increase	VERB
fnp-3500	275	7	expression	expression	NOUN
fnp-3500	275	8	of	of	ADP
fnp-3500	275	9	long	long	ADJ
fnp-3500	275	10	-	-	PUNCT
fnp-3500	275	11	terminal	terminal	ADJ
fnp-3500	275	12	repeat	repeat	NOUN
fnp-3500	275	13	and	and	CCONJ
fnp-3500	275	14	non	non	ADJ
fnp-3500	275	15	-	-	ADJ
fnp-3500	275	16	long	long	ADJ
fnp-3500	275	17	terminal	terminal	ADJ
fnp-3500	275	18	repeat	repeat	NOUN
fnp-3500	275	19	retrotransposons	retrotransposon	NOUN
fnp-3500	275	20	in	in	ADP
fnp-3500	275	21	microglia	microglia	NOUN
fnp-3500	275	22	and	and	CCONJ
fnp-3500	275	23	astrocytes	astrocyte	NOUN
fnp-3500	275	24	compared	compare	VERB
fnp-3500	275	25	to	to	ADP
fnp-3500	275	26	other	other	ADJ
fnp-3500	275	27	cell	cell	NOUN
fnp-3500	275	28	types	type	NOUN
fnp-3500	275	29	.	.	PUNCT
fnp-3500	276	1	surprisingly	surprisingly	ADV
fnp-3500	276	2	,	,	PUNCT
fnp-3500	276	3	these	these	DET
fnp-3500	276	4	expression	expression	NOUN
fnp-3500	276	5	changes	change	NOUN
fnp-3500	276	6	were	be	AUX
fnp-3500	276	7	not	not	PART
fnp-3500	276	8	associated	associate	VERB
fnp-3500	276	9	with	with	ADP
fnp-3500	276	10	an	an	DET
fnp-3500	276	11	increased	increase	VERB
fnp-3500	276	12	expression	expression	NOUN
fnp-3500	276	13	of	of	ADP
fnp-3500	276	14	genes	gene	NOUN
fnp-3500	276	15	encoding	encode	VERB
fnp-3500	276	16	inflammatory	inflammatory	ADJ
fnp-3500	276	17	mediators	mediator	NOUN
fnp-3500	276	18	.	.	PUNCT
fnp-3500	277	1	we	we	PRON
fnp-3500	277	2	confirmed	confirm	VERB
fnp-3500	277	3	these	these	DET
fnp-3500	277	4	results	result	NOUN
fnp-3500	277	5	using	use	VERB
fnp-3500	277	6	bulk	bulk	ADJ
fnp-3500	277	7	rna	rna	NOUN
fnp-3500	277	8	sequencing	sequencing	NOUN
fnp-3500	277	9	.	.	PUNCT
fnp-3500	278	1	conclusion	conclusion	NOUN
fnp-3500	278	2	:	:	PUNCT
fnp-3500	278	3	our	our	PRON
fnp-3500	278	4	findings	finding	NOUN
fnp-3500	278	5	underscore	underscore	VERB
fnp-3500	278	6	the	the	DET
fnp-3500	278	7	ability	ability	NOUN
fnp-3500	278	8	of	of	ADP
fnp-3500	278	9	brain	brain	NOUN
fnp-3500	278	10	tissues	tissue	NOUN
fnp-3500	278	11	to	to	PART
fnp-3500	278	12	attenuate	attenuate	VERB
fnp-3500	278	13	an	an	DET
fnp-3500	278	14	inflammatory	inflammatory	ADJ
fnp-3500	278	15	response	response	NOUN
fnp-3500	278	16	despite	despite	SCONJ
fnp-3500	278	17	continuing	continue	VERB
fnp-3500	278	18	presence	presence	NOUN
fnp-3500	278	19	of	of	ADP
fnp-3500	278	20	an	an	DET
fnp-3500	278	21	immunogenic	immunogenic	ADJ
fnp-3500	278	22	agent	agent	NOUN
fnp-3500	278	23	with	with	ADP
fnp-3500	278	24	direct	direct	ADJ
fnp-3500	278	25	therapeutic	therapeutic	ADJ
fnp-3500	278	26	implications	implication	NOUN
fnp-3500	278	27	for	for	ADP
fnp-3500	278	28	unresolving	unresolve	VERB
fnp-3500	278	29	chronic	chronic	ADJ
fnp-3500	278	30	inflammatory	inflammatory	ADJ
fnp-3500	278	31	conditions	condition	NOUN
fnp-3500	278	32	.	.	PUNCT
fnp-3500	278	33	  	  	SPACE
fnp-3500	279	1	postersession	postersession	PROPN
fnp-3500	279	2	ii	ii	PROPN
fnp-3500	279	3	–	–	PUNCT
fnp-3500	279	4	neurooncology	neurooncology	NOUN
fnp-3500	279	5	pii-01	pii-01	NOUN
fnp-3500	279	6	free	free	ADJ
fnp-3500	279	7	neuropathol	neuropathol	NOUN
fnp-3500	279	8	2:22:32	2:22:32	PROPN
fnp-3500	279	9	dna	dna	PROPN
fnp-3500	279	10	methylation	methylation	NOUN
fnp-3500	279	11	-	-	PUNCT
fnp-3500	279	12	based	base	VERB
fnp-3500	279	13	classification	classification	NOUN
fnp-3500	279	14	of	of	ADP
fnp-3500	279	15	sinonasal	sinonasal	ADJ
fnp-3500	279	16	tumors	tumor	NOUN
fnp-3500	279	17	p.	p.	PROPN
fnp-3500	280	1	jurmeister1	jurmeister1	PROPN
fnp-3500	280	2	,	,	PUNCT
fnp-3500	280	3	s.	s.	PROPN
fnp-3500	280	4	glöß2	glöß2	PROPN
fnp-3500	280	5	,	,	PUNCT
fnp-3500	280	6	r.	r.	PROPN
fnp-3500	280	7	roller3	roller3	PROPN
fnp-3500	280	8	,	,	PUNCT
fnp-3500	280	9	s.	s.	PROPN
fnp-3500	280	10	schmid2	schmid2	PROPN
fnp-3500	280	11	,	,	PUNCT
fnp-3500	280	12	r.	r.	PROPN
fnp-3500	280	13	fritz3	fritz3	PROPN
fnp-3500	280	14	,	,	PUNCT
fnp-3500	280	15	a.	a.	NOUN
fnp-3500	280	16	thieme2	thieme2	PROPN
fnp-3500	280	17	,	,	PUNCT
fnp-3500	280	18	c.	c.	PROPN
fnp-3500	280	19	friedrich3	friedrich3	PROPN
fnp-3500	280	20	,	,	PUNCT
fnp-3500	280	21	i.	i.	PROPN
fnp-3500	280	22	hoffmann3	hoffmann3	PROPN
fnp-3500	280	23	,	,	PUNCT
fnp-3500	280	24	m.	m.	NOUN
fnp-3500	280	25	leitheiser3	leitheiser3	PROPN
fnp-3500	280	26	,	,	PUNCT
fnp-3500	280	27	p.	p.	NOUN
fnp-3500	280	28	mertins4	mertins4	PROPN
fnp-3500	280	29	,	,	PUNCT
fnp-3500	280	30	f.	f.	PROPN
fnp-3500	280	31	klauschen1	klauschen1	PROPN
fnp-3500	280	32	,	,	PUNCT
fnp-3500	280	33	d.	d.	PROPN
fnp-3500	280	34	capper2	capper2	PROPN
fnp-3500	281	1	1	1	NUM
fnp-3500	281	2	ludwig	ludwig	PROPN
fnp-3500	281	3	-	-	PUNCT
fnp-3500	281	4	maximilians	maximilians	PROPN
fnp-3500	281	5	-	-	PUNCT
fnp-3500	281	6	university	university	NOUN
fnp-3500	281	7	munich	munich	PROPN
fnp-3500	281	8	,	,	PUNCT
fnp-3500	281	9	institute	institute	PROPN
fnp-3500	281	10	of	of	ADP
fnp-3500	281	11	pathology	pathology	PROPN
fnp-3500	281	12	,	,	PUNCT
fnp-3500	281	13	münchen	münchen	PROPN
fnp-3500	281	14	,	,	PUNCT
fnp-3500	281	15	germany	germany	PROPN
fnp-3500	281	16	2	2	NUM
fnp-3500	281	17	charité	charité	PROPN
fnp-3500	281	18	–	–	PUNCT
fnp-3500	281	19	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	281	20	berlin	berlin	PROPN
fnp-3500	281	21	,	,	PUNCT
fnp-3500	281	22	department	department	NOUN
fnp-3500	281	23	of	of	ADP
fnp-3500	281	24	neuropathology	neuropathology	NOUN
fnp-3500	281	25	,	,	PUNCT
fnp-3500	281	26	berlin	berlin	PROPN
fnp-3500	281	27	,	,	PUNCT
fnp-3500	281	28	germany	germany	PROPN
fnp-3500	281	29	3	3	NUM
fnp-3500	281	30	charité	charité	PROPN
fnp-3500	281	31	–	–	PUNCT
fnp-3500	281	32	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	281	33	berlin	berlin	PROPN
fnp-3500	281	34	,	,	PUNCT
fnp-3500	281	35	institute	institute	PROPN
fnp-3500	281	36	of	of	ADP
fnp-3500	281	37	pathology	pathology	PROPN
fnp-3500	281	38	,	,	PUNCT
fnp-3500	281	39	berlin	berlin	PROPN
fnp-3500	281	40	,	,	PUNCT
fnp-3500	281	41	germany	germany	PROPN
fnp-3500	281	42	4	4	NUM
fnp-3500	281	43	max	max	PROPN
fnp-3500	281	44	-	-	PUNCT
fnp-3500	281	45	delbrück	delbrück	PROPN
fnp-3500	281	46	-	-	PUNCT
fnp-3500	281	47	centrum	centrum	PROPN
fnp-3500	281	48	für	für	PROPN
fnp-3500	281	49	molekulare	molekulare	PROPN
fnp-3500	281	50	medizin	medizin	PROPN
fnp-3500	281	51	,	,	PUNCT
fnp-3500	281	52	berlin	berlin	PROPN
fnp-3500	281	53	,	,	PUNCT
fnp-3500	281	54	germany	germany	PROPN
fnp-3500	281	55	introduction	introduction	NOUN
fnp-3500	281	56	:	:	PUNCT
fnp-3500	281	57	the	the	DET
fnp-3500	281	58	histopathological	histopathological	ADJ
fnp-3500	281	59	diagnosis	diagnosis	NOUN
fnp-3500	281	60	of	of	ADP
fnp-3500	281	61	sinonasal	sinonasal	ADJ
fnp-3500	281	62	tumors	tumor	NOUN
fnp-3500	281	63	is	be	AUX
fnp-3500	281	64	challenging	challenge	VERB
fnp-3500	281	65	as	as	SCONJ
fnp-3500	281	66	it	it	PRON
fnp-3500	281	67	encompasses	encompass	VERB
fnp-3500	281	68	a	a	DET
fnp-3500	281	69	heterogenous	heterogenous	ADJ
fnp-3500	281	70	spectrum	spectrum	NOUN
fnp-3500	281	71	of	of	ADP
fnp-3500	281	72	diverse	diverse	ADJ
fnp-3500	281	73	differential	differential	NOUN
fnp-3500	281	74	diagnoses	diagnosis	NOUN
fnp-3500	281	75	as	as	ADV
fnp-3500	281	76	well	well	ADV
fnp-3500	281	77	as	as	ADP
fnp-3500	281	78	poorly	poorly	ADV
fnp-3500	281	79	defined	define	VERB
fnp-3500	281	80	,	,	PUNCT
fnp-3500	281	81	disputed	dispute	VERB
fnp-3500	281	82	entities	entity	NOUN
fnp-3500	281	83	such	such	ADJ
fnp-3500	281	84	as	as	ADP
fnp-3500	281	85	sinonasal	sinonasal	ADJ
fnp-3500	281	86	undifferentiated	undifferentiated	ADJ
fnp-3500	281	87	carcinomas	carcinoma	NOUN
fnp-3500	281	88	(	(	PUNCT
fnp-3500	281	89	snucs	snucs	NOUN
fnp-3500	281	90	)	)	PUNCT
fnp-3500	281	91	.	.	PUNCT
fnp-3500	282	1	objectives	objective	NOUN
fnp-3500	282	2	:	:	PUNCT
fnp-3500	282	3	in	in	ADP
fnp-3500	282	4	this	this	DET
fnp-3500	282	5	study	study	NOUN
fnp-3500	282	6	,	,	PUNCT
fnp-3500	282	7	we	we	PRON
fnp-3500	282	8	aimed	aim	VERB
fnp-3500	282	9	to	to	PART
fnp-3500	282	10	develop	develop	VERB
fnp-3500	282	11	a	a	DET
fnp-3500	282	12	dna	dna	PROPN
fnp-3500	282	13	methylation	methylation	NOUN
fnp-3500	282	14	-	-	PUNCT
fnp-3500	282	15	based	base	VERB
fnp-3500	282	16	classification	classification	NOUN
fnp-3500	282	17	algorithm	algorithm	NOUN
fnp-3500	282	18	for	for	ADP
fnp-3500	282	19	sinonasal	sinonasal	ADJ
fnp-3500	282	20	tumors	tumor	NOUN
fnp-3500	282	21	and	and	CCONJ
fnp-3500	282	22	to	to	PART
fnp-3500	282	23	elucidate	elucidate	VERB
fnp-3500	282	24	the	the	DET
fnp-3500	282	25	molecular	molecular	ADJ
fnp-3500	282	26	background	background	NOUN
fnp-3500	282	27	of	of	ADP
fnp-3500	282	28	snucs	snucs	NOUN
fnp-3500	282	29	.	.	PUNCT
fnp-3500	283	1	materials	material	NOUN
fnp-3500	283	2	&	&	CCONJ
fnp-3500	283	3	methods	method	NOUN
fnp-3500	283	4	:	:	PUNCT
fnp-3500	283	5	we	we	PRON
fnp-3500	283	6	established	establish	VERB
fnp-3500	283	7	a	a	DET
fnp-3500	283	8	cohort	cohort	NOUN
fnp-3500	283	9	of	of	ADP
fnp-3500	283	10	dna	dna	PROPN
fnp-3500	283	11	methylation	methylation	NOUN
fnp-3500	283	12	profiles	profile	NOUN
fnp-3500	283	13	from	from	ADP
fnp-3500	283	14	374	374	NUM
fnp-3500	283	15	sinonasal	sinonasal	ADJ
fnp-3500	283	16	tumor	tumor	NOUN
fnp-3500	283	17	specimens	specimen	NOUN
fnp-3500	283	18	,	,	PUNCT
fnp-3500	283	19	covering	cover	VERB
fnp-3500	283	20	17	17	NUM
fnp-3500	283	21	tumor	tumor	NOUN
fnp-3500	283	22	entities	entity	NOUN
fnp-3500	283	23	and	and	CCONJ
fnp-3500	283	24	normal	normal	ADJ
fnp-3500	283	25	control	control	NOUN
fnp-3500	283	26	tissue	tissue	NOUN
fnp-3500	283	27	.	.	PUNCT
fnp-3500	284	1	furthermore	furthermore	ADV
fnp-3500	284	2	,	,	PUNCT
fnp-3500	284	3	we	we	PRON
fnp-3500	284	4	performed	perform	VERB
fnp-3500	284	5	dna	dna	NOUN
fnp-3500	284	6	sequencing	sequencing	NOUN
fnp-3500	284	7	and	and	CCONJ
fnp-3500	284	8	mass	mass	ADJ
fnp-3500	284	9	spectrometry	spectrometry	NOUN
fnp-3500	284	10	-	-	PUNCT
fnp-3500	284	11	based	base	VERB
fnp-3500	284	12	proteomics	proteomic	NOUN
fnp-3500	284	13	of	of	ADP
fnp-3500	284	14	selected	select	VERB
fnp-3500	284	15	cases	case	NOUN
fnp-3500	284	16	.	.	PUNCT
fnp-3500	285	1	results	result	NOUN
fnp-3500	285	2	:	:	PUNCT
fnp-3500	285	3	a	a	DET
fnp-3500	285	4	machine	machine	NOUN
fnp-3500	285	5	learning	learn	VERB
fnp-3500	285	6	algorithm	algorithm	NOUN
fnp-3500	285	7	was	be	AUX
fnp-3500	285	8	able	able	ADJ
fnp-3500	285	9	to	to	PART
fnp-3500	285	10	reliably	reliably	ADV
fnp-3500	285	11	classifiy	classifiy	VERB
fnp-3500	285	12	sinonasal	sinonasal	ADJ
fnp-3500	285	13	tumors	tumor	NOUN
fnp-3500	285	14	based	base	VERB
fnp-3500	285	15	on	on	ADP
fnp-3500	285	16	their	their	PRON
fnp-3500	285	17	dna	dna	PROPN
fnp-3500	285	18	methylation	methylation	NOUN
fnp-3500	285	19	profiles	profile	NOUN
fnp-3500	285	20	with	with	ADP
fnp-3500	285	21	clinical	clinical	ADJ
fnp-3500	285	22	-	-	PUNCT
fnp-3500	285	23	grade	grade	NOUN
fnp-3500	285	24	accuracy	accuracy	NOUN
fnp-3500	285	25	.	.	PUNCT
fnp-3500	286	1	we	we	PRON
fnp-3500	286	2	further	far	ADV
fnp-3500	286	3	showed	show	VERB
fnp-3500	286	4	that	that	SCONJ
fnp-3500	286	5	tumors	tumor	NOUN
fnp-3500	286	6	with	with	ADP
fnp-3500	286	7	snuc	snuc	NOUN
fnp-3500	286	8	morphology	morphology	NOUN
fnp-3500	286	9	can	can	AUX
fnp-3500	286	10	be	be	AUX
fnp-3500	286	11	assigned	assign	VERB
fnp-3500	286	12	to	to	ADP
fnp-3500	286	13	four	four	NUM
fnp-3500	286	14	molecular	molecular	ADJ
fnp-3500	286	15	classes	class	NOUN
fnp-3500	286	16	defined	define	VERB
fnp-3500	286	17	by	by	ADP
fnp-3500	286	18	distinct	distinct	ADJ
fnp-3500	286	19	epigenetic	epigenetic	ADJ
fnp-3500	286	20	,	,	PUNCT
fnp-3500	286	21	mutational	mutational	ADJ
fnp-3500	286	22	and	and	CCONJ
fnp-3500	286	23	proteomic	proteomic	ADJ
fnp-3500	286	24	profiles	profile	NOUN
fnp-3500	286	25	.	.	PUNCT
fnp-3500	287	1	this	this	PRON
fnp-3500	287	2	included	include	VERB
fnp-3500	287	3	two	two	NUM
fnp-3500	287	4	classes	class	NOUN
fnp-3500	287	5	with	with	ADP
fnp-3500	287	6	clear	clear	ADJ
fnp-3500	287	7	neuroendocrine	neuroendocrine	ADJ
fnp-3500	287	8	differentiation	differentiation	NOUN
fnp-3500	287	9	in	in	ADP
fnp-3500	287	10	proteomics	proteomic	NOUN
fnp-3500	287	11	analysis	analysis	NOUN
fnp-3500	287	12	which	which	PRON
fnp-3500	287	13	were	be	AUX
fnp-3500	287	14	characterized	characterize	VERB
fnp-3500	287	15	by	by	ADP
fnp-3500	287	16	either	either	DET
fnp-3500	287	17	idh2	idh2	PROPN
fnp-3500	287	18	mutations	mutation	NOUN
fnp-3500	287	19	or	or	CCONJ
fnp-3500	287	20	swi	swi	PROPN
fnp-3500	287	21	/	/	SYM
fnp-3500	287	22	snf	snf	PROPN
fnp-3500	287	23	chromatin	chromatin	NOUN
fnp-3500	287	24	remodeling	remodeling	NOUN
fnp-3500	287	25	complex	complex	NOUN
fnp-3500	287	26	(	(	PUNCT
fnp-3500	287	27	smarca4	smarca4	NOUN
fnp-3500	287	28	/	/	SYM
fnp-3500	287	29	arid1a	arid1a	PROPN
fnp-3500	287	30	)	)	PUNCT
fnp-3500	287	31	mutations	mutation	NOUN
fnp-3500	287	32	and	and	CCONJ
fnp-3500	287	33	overall	overall	ADJ
fnp-3500	287	34	favorable	favorable	ADJ
fnp-3500	287	35	clinical	clinical	ADJ
fnp-3500	287	36	course	course	NOUN
fnp-3500	287	37	.	.	PUNCT
fnp-3500	288	1	the	the	DET
fnp-3500	288	2	third	third	ADJ
fnp-3500	288	3	group	group	NOUN
fnp-3500	288	4	comprised	comprise	VERB
fnp-3500	288	5	highly	highly	ADV
fnp-3500	288	6	aggressive	aggressive	ADJ
fnp-3500	288	7	tumors	tumor	NOUN
fnp-3500	288	8	,	,	PUNCT
fnp-3500	288	9	driven	drive	VERB
fnp-3500	288	10	by	by	ADP
fnp-3500	288	11	smarcb1	smarcb1	NOUN
fnp-3500	288	12	-	-	PUNCT
fnp-3500	288	13	deficiency	deficiency	NOUN
fnp-3500	288	14	.	.	PUNCT
fnp-3500	289	1	the	the	DET
fnp-3500	289	2	fourth	fourth	ADJ
fnp-3500	289	3	snuc	snuc	NOUN
fnp-3500	289	4	class	class	NOUN
fnp-3500	289	5	contained	contain	VERB
fnp-3500	289	6	tumors	tumor	NOUN
fnp-3500	289	7	that	that	PRON
fnp-3500	289	8	actually	actually	ADV
fnp-3500	289	9	represented	represent	VERB
fnp-3500	289	10	previously	previously	ADV
fnp-3500	289	11	misclassified	misclassifie	VERB
fnp-3500	289	12	adenoid	adenoid	ADJ
fnp-3500	289	13	-	-	PUNCT
fnp-3500	289	14	cystic	cystic	ADJ
fnp-3500	289	15	carcinomas	carcinoma	NOUN
fnp-3500	289	16	,	,	PUNCT
fnp-3500	289	17	which	which	PRON
fnp-3500	289	18	was	be	AUX
fnp-3500	289	19	supported	support	VERB
fnp-3500	289	20	by	by	ADP
fnp-3500	289	21	recurrent	recurrent	ADJ
fnp-3500	289	22	myb	myb	NOUN
fnp-3500	289	23	translocations	translocation	NOUN
fnp-3500	289	24	and	and	CCONJ
fnp-3500	289	25	the	the	DET
fnp-3500	289	26	resemeblance	resemeblance	NOUN
fnp-3500	289	27	of	of	ADP
fnp-3500	289	28	these	these	DET
fnp-3500	289	29	specimens	specimen	NOUN
fnp-3500	289	30	with	with	ADP
fnp-3500	289	31	serous	serous	ADJ
fnp-3500	289	32	cell	cell	NOUN
fnp-3500	289	33	of	of	ADP
fnp-3500	289	34	submucosal	submucosal	NOUN
fnp-3500	289	35	glands	gland	NOUN
fnp-3500	289	36	in	in	ADP
fnp-3500	289	37	proteomics	proteomic	NOUN
fnp-3500	289	38	analysis	analysis	NOUN
fnp-3500	289	39	.	.	PUNCT
fnp-3500	290	1	conclusions	conclusion	NOUN
fnp-3500	290	2	:	:	PUNCT
fnp-3500	290	3	our	our	PRON
fnp-3500	290	4	dna	dna	PROPN
fnp-3500	290	5	methylation	methylation	NOUN
fnp-3500	290	6	-	-	PUNCT
fnp-3500	290	7	based	base	VERB
fnp-3500	290	8	machine	machine	NOUN
fnp-3500	290	9	learning	learn	VERB
fnp-3500	290	10	algorithm	algorithm	NOUN
fnp-3500	290	11	could	could	AUX
fnp-3500	290	12	greatly	greatly	ADV
fnp-3500	290	13	improve	improve	VERB
fnp-3500	290	14	the	the	DET
fnp-3500	290	15	diagnostics	diagnostic	NOUN
fnp-3500	290	16	of	of	ADP
fnp-3500	290	17	challenging	challenge	VERB
fnp-3500	290	18	sinonasal	sinonasal	ADJ
fnp-3500	290	19	tumors	tumor	NOUN
fnp-3500	290	20	.	.	PUNCT
fnp-3500	291	1	furthermore	furthermore	ADV
fnp-3500	291	2	,	,	PUNCT
fnp-3500	291	3	we	we	PRON
fnp-3500	291	4	provide	provide	VERB
fnp-3500	291	5	solid	solid	ADJ
fnp-3500	291	6	proof	proof	NOUN
fnp-3500	291	7	that	that	SCONJ
fnp-3500	291	8	sinonasal	sinonasal	ADJ
fnp-3500	291	9	tumors	tumor	NOUN
fnp-3500	291	10	are	be	AUX
fnp-3500	291	11	not	not	PART
fnp-3500	291	12	as	as	ADV
fnp-3500	291	13	undifferentiated	undifferentiated	ADJ
fnp-3500	291	14	as	as	SCONJ
fnp-3500	291	15	their	their	PRON
fnp-3500	291	16	current	current	ADJ
fnp-3500	291	17	terminology	terminology	NOUN
fnp-3500	291	18	implies	imply	VERB
fnp-3500	291	19	,	,	PUNCT
fnp-3500	291	20	but	but	CCONJ
fnp-3500	291	21	rather	rather	ADV
fnp-3500	291	22	represent	represent	VERB
fnp-3500	291	23	distinct	distinct	ADJ
fnp-3500	291	24	molecular	molecular	ADJ
fnp-3500	291	25	groups	group	NOUN
fnp-3500	291	26	with	with	ADP
fnp-3500	291	27	at	at	ADV
fnp-3500	291	28	least	least	ADV
fnp-3500	291	29	two	two	NUM
fnp-3500	291	30	classes	class	NOUN
fnp-3500	291	31	showing	show	VERB
fnp-3500	291	32	clear	clear	ADJ
fnp-3500	291	33	neuroendocrine	neuroendocrine	ADJ
fnp-3500	291	34	differentiation	differentiation	NOUN
fnp-3500	291	35	.	.	PUNCT
fnp-3500	292	1	fig	fig	NOUN
fnp-3500	292	2	.	.	PUNCT
fnp-3500	293	1	1	1	NUM
fnp-3500	293	2	  	  	SPACE
fnp-3500	293	3	pii-02	pii-02	ADV
fnp-3500	293	4	free	free	ADJ
fnp-3500	293	5	neuropathol	neuropathol	NOUN
fnp-3500	293	6	2:22:34	2:22:34	NUM
fnp-3500	293	7	deep	deep	ADJ
fnp-3500	293	8	learning	learning	NOUN
fnp-3500	293	9	aided	aid	VERB
fnp-3500	293	10	mitotic	mitotic	ADJ
fnp-3500	293	11	figure	figure	NOUN
fnp-3500	293	12	count	count	NOUN
fnp-3500	293	13	in	in	ADP
fnp-3500	293	14	human	human	ADJ
fnp-3500	293	15	meningiomas	meningioma	NOUN
fnp-3500	293	16	based	base	VERB
fnp-3500	293	17	on	on	ADP
fnp-3500	293	18	the	the	DET
fnp-3500	293	19	open	open	ADJ
fnp-3500	293	20	-	-	PUNCT
fnp-3500	293	21	source	source	NOUN
fnp-3500	293	22	software	software	NOUN
fnp-3500	293	23	sliderunner	sliderunner	PROPN
fnp-3500	293	24	s.	s.	PROPN
fnp-3500	293	25	jabari1	jabari1	PROPN
fnp-3500	293	26	,	,	PUNCT
fnp-3500	293	27	c.	c.	PROPN
fnp-3500	293	28	bertram2	bertram2	PROPN
fnp-3500	293	29	,	,	PUNCT
fnp-3500	293	30	r.	r.	PROPN
fnp-3500	293	31	coras1	coras1	PROPN
fnp-3500	293	32	,	,	PUNCT
fnp-3500	293	33	a.	a.	NOUN
fnp-3500	293	34	maier3	maier3	PROPN
fnp-3500	293	35	,	,	PUNCT
fnp-3500	293	36	i.	i.	PROPN
fnp-3500	293	37	blümcke1	blümcke1	PROPN
fnp-3500	293	38	,	,	PUNCT
fnp-3500	293	39	m.	m.	NOUN
fnp-3500	293	40	aubreville4	aubreville4	NOUN
fnp-3500	293	41	1	1	NUM
fnp-3500	293	42	university	university	NOUN
fnp-3500	293	43	hospitals	hospital	NOUN
fnp-3500	293	44	erlangen	erlangen	PROPN
fnp-3500	293	45	,	,	PUNCT
fnp-3500	293	46	institute	institute	NOUN
fnp-3500	293	47	for	for	ADP
fnp-3500	293	48	neuropathology	neuropathology	NOUN
fnp-3500	293	49	,	,	PUNCT
fnp-3500	293	50	erlangen	erlangen	PROPN
fnp-3500	293	51	,	,	PUNCT
fnp-3500	293	52	germany	germany	PROPN
fnp-3500	293	53	2	2	NUM
fnp-3500	293	54	veterinärmedizinische	veterinärmedizinische	PROPN
fnp-3500	293	55	universität	universität	PROPN
fnp-3500	293	56	wien	wien	PROPN
fnp-3500	293	57	,	,	PUNCT
fnp-3500	293	58	institut	institut	PROPN
fnp-3500	293	59	für	für	PROPN
fnp-3500	293	60	pathologie	pathologie	PROPN
fnp-3500	293	61	,	,	PUNCT
fnp-3500	293	62	vienna	vienna	PROPN
fnp-3500	293	63	,	,	PUNCT
fnp-3500	293	64	austria	austria	PROPN
fnp-3500	293	65	3	3	NUM
fnp-3500	293	66	lehrstuhl	lehrstuhl	PROPN
fnp-3500	293	67	für	für	PROPN
fnp-3500	293	68	mustererkennung	mustererkennung	PROPN
fnp-3500	293	69	,	,	PUNCT
fnp-3500	293	70	fau	fau	PROPN
fnp-3500	293	71	,	,	PUNCT
fnp-3500	293	72	erlangen	erlangen	PROPN
fnp-3500	293	73	,	,	PUNCT
fnp-3500	293	74	germany	germany	PROPN
fnp-3500	293	75	4	4	NUM
fnp-3500	293	76	image	image	NOUN
fnp-3500	293	77	understanding	understanding	NOUN
fnp-3500	293	78	and	and	CCONJ
fnp-3500	293	79	medical	medical	ADJ
fnp-3500	293	80	application	application	NOUN
fnp-3500	293	81	of	of	ADP
fnp-3500	293	82	artificial	artificial	ADJ
fnp-3500	293	83	intelligence	intelligence	NOUN
fnp-3500	293	84	,	,	PUNCT
fnp-3500	293	85	ingolstadt	ingolstadt	NOUN
fnp-3500	293	86	,	,	PUNCT
fnp-3500	293	87	germany	germany	PROPN
fnp-3500	293	88	introduction	introduction	NOUN
fnp-3500	293	89	:	:	PUNCT
fnp-3500	293	90	the	the	DET
fnp-3500	293	91	world	world	PROPN
fnp-3500	293	92	health	health	NOUN
fnp-3500	293	93	organization	organization	NOUN
fnp-3500	293	94	(	(	PUNCT
fnp-3500	293	95	who	who	PRON
fnp-3500	293	96	)	)	PUNCT
fnp-3500	293	97	classification	classification	NOUN
fnp-3500	293	98	of	of	ADP
fnp-3500	293	99	brain	brain	NOUN
fnp-3500	293	100	tumors	tumor	NOUN
fnp-3500	293	101	describes	describe	VERB
fnp-3500	293	102	three	three	NUM
fnp-3500	293	103	grades	grade	NOUN
fnp-3500	293	104	of	of	ADP
fnp-3500	293	105	meningioma	meningioma	NOUN
fnp-3500	293	106	:	:	PUNCT
fnp-3500	293	107	who	who	PRON
fnp-3500	293	108	i	i	PROPN
fnp-3500	293	109	-	-	PUNCT
fnp-3500	293	110	iii	iii	PROPN
fnp-3500	293	111	.	.	PUNCT
fnp-3500	294	1	a	a	DET
fnp-3500	294	2	major	major	ADJ
fnp-3500	294	3	factor	factor	NOUN
fnp-3500	294	4	that	that	PRON
fnp-3500	294	5	distinguishes	distinguish	VERB
fnp-3500	294	6	the	the	DET
fnp-3500	294	7	classes	class	NOUN
fnp-3500	294	8	is	be	AUX
fnp-3500	294	9	the	the	DET
fnp-3500	294	10	number	number	NOUN
fnp-3500	294	11	of	of	ADP
fnp-3500	294	12	mitotic	mitotic	ADJ
fnp-3500	294	13	figures	figure	NOUN
fnp-3500	294	14	.	.	PUNCT
fnp-3500	295	1	detecting	detect	VERB
fnp-3500	295	2	and	and	CCONJ
fnp-3500	295	3	counting	count	VERB
fnp-3500	295	4	mitotic	mitotic	ADJ
fnp-3500	295	5	figures	figure	NOUN
fnp-3500	295	6	reliably	reliably	ADV
fnp-3500	295	7	in	in	ADP
fnp-3500	295	8	meningioma	meningioma	NOUN
fnp-3500	295	9	is	be	AUX
fnp-3500	295	10	,	,	PUNCT
fnp-3500	295	11	therefore	therefore	ADV
fnp-3500	295	12	,	,	PUNCT
fnp-3500	295	13	an	an	DET
fnp-3500	295	14	essential	essential	ADJ
fnp-3500	295	15	part	part	NOUN
fnp-3500	295	16	of	of	ADP
fnp-3500	295	17	the	the	DET
fnp-3500	295	18	diagnostic	diagnostic	ADJ
fnp-3500	295	19	workup	workup	NOUN
fnp-3500	295	20	.	.	PUNCT
fnp-3500	296	1	objectives	objective	NOUN
fnp-3500	296	2	:	:	PUNCT
fnp-3500	296	3	however	however	ADV
fnp-3500	296	4	,	,	PUNCT
fnp-3500	296	5	detecting	detect	VERB
fnp-3500	296	6	mitotic	mitotic	ADJ
fnp-3500	296	7	figures	figure	NOUN
fnp-3500	296	8	quickly	quickly	ADV
fnp-3500	296	9	,	,	PUNCT
fnp-3500	296	10	reliably	reliably	ADV
fnp-3500	296	11	,	,	PUNCT
fnp-3500	296	12	and	and	CCONJ
fnp-3500	296	13	comprehensively	comprehensively	ADV
fnp-3500	296	14	in	in	ADP
fnp-3500	296	15	a	a	DET
fnp-3500	296	16	tissue	tissue	NOUN
fnp-3500	296	17	section	section	NOUN
fnp-3500	296	18	is	be	AUX
fnp-3500	296	19	a	a	DET
fnp-3500	296	20	major	major	ADJ
fnp-3500	296	21	challenge	challenge	NOUN
fnp-3500	296	22	.	.	PUNCT
fnp-3500	297	1	for	for	ADP
fnp-3500	297	2	this	this	DET
fnp-3500	297	3	reason	reason	NOUN
fnp-3500	297	4	,	,	PUNCT
fnp-3500	297	5	we	we	PRON
fnp-3500	297	6	developed	develop	VERB
fnp-3500	297	7	a	a	DET
fnp-3500	297	8	technical	technical	ADJ
fnp-3500	297	9	assistance	assistance	NOUN
fnp-3500	297	10	system	system	NOUN
fnp-3500	297	11	that	that	PRON
fnp-3500	297	12	detects	detect	VERB
fnp-3500	297	13	mitotic	mitotic	ADJ
fnp-3500	297	14	figures	figure	NOUN
fnp-3500	297	15	on	on	ADP
fnp-3500	297	16	whole	whole	ADJ
fnp-3500	297	17	-	-	PUNCT
fnp-3500	297	18	slide	slide	NOUN
fnp-3500	297	19	-	-	PUNCT
fnp-3500	297	20	images	image	NOUN
fnp-3500	297	21	and	and	CCONJ
fnp-3500	297	22	visualizes	visualize	VERB
fnp-3500	297	23	these	these	PRON
fnp-3500	297	24	as	as	ADP
fnp-3500	297	25	a	a	DET
fnp-3500	297	26	heat	heat	NOUN
fnp-3500	297	27	map	map	NOUN
fnp-3500	297	28	showing	show	VERB
fnp-3500	297	29	the	the	DET
fnp-3500	297	30	mitotic	mitotic	ADJ
fnp-3500	297	31	density	density	NOUN
fnp-3500	297	32	in	in	ADP
fnp-3500	297	33	almost	almost	ADV
fnp-3500	297	34	real	real	ADJ
fnp-3500	297	35	-	-	PUNCT
fnp-3500	297	36	time	time	NOUN
fnp-3500	297	37	.	.	PUNCT
fnp-3500	298	1	patients	patient	NOUN
fnp-3500	298	2	&	&	CCONJ
fnp-3500	298	3	methods	method	NOUN
fnp-3500	298	4	:	:	PUNCT
fnp-3500	298	5	meningioma	meningioma	NOUN
fnp-3500	298	6	samples	sample	NOUN
fnp-3500	298	7	were	be	AUX
fnp-3500	298	8	retrospectively	retrospectively	ADV
fnp-3500	298	9	collected	collect	VERB
fnp-3500	298	10	from	from	ADP
fnp-3500	298	11	the	the	DET
fnp-3500	298	12	dept	dept	NOUN
fnp-3500	298	13	.	.	PROPN
fnp-3500	298	14	of	of	ADP
fnp-3500	298	15	neuropathology	neuropathology	PROPN
fnp-3500	298	16	erlangen	erlangen	PROPN
fnp-3500	298	17	,	,	PUNCT
fnp-3500	298	18	germany	germany	PROPN
fnp-3500	298	19	.	.	PUNCT
fnp-3500	299	1	all	all	DET
fnp-3500	299	2	samples	sample	NOUN
fnp-3500	299	3	were	be	AUX
fnp-3500	299	4	rereviewed	rereviewe	VERB
fnp-3500	299	5	by	by	ADP
fnp-3500	299	6	an	an	DET
fnp-3500	299	7	expert	expert	ADJ
fnp-3500	299	8	neuropathologist	neuropathologist	NOUN
fnp-3500	299	9	and	and	CCONJ
fnp-3500	299	10	subsequently	subsequently	ADV
fnp-3500	299	11	digitized	digitize	VERB
fnp-3500	299	12	using	use	VERB
fnp-3500	299	13	the	the	DET
fnp-3500	299	14	hamamatsu	hamamatsu	NOUN
fnp-3500	299	15	s60	s60	NOUN
fnp-3500	299	16	digital	digital	ADJ
fnp-3500	299	17	slide	slide	NOUN
fnp-3500	299	18	scanner	scanner	NOUN
fnp-3500	299	19	.	.	PUNCT
fnp-3500	300	1	the	the	DET
fnp-3500	300	2	slides	slide	NOUN
fnp-3500	300	3	have	have	AUX
fnp-3500	300	4	been	be	AUX
fnp-3500	300	5	completely	completely	ADV
fnp-3500	300	6	annotated	annotate	VERB
fnp-3500	300	7	for	for	ADP
fnp-3500	300	8	mitotic	mitotic	ADJ
fnp-3500	300	9	figures	figure	NOUN
fnp-3500	300	10	and	and	CCONJ
fnp-3500	300	11	we	we	PRON
fnp-3500	300	12	provide	provide	VERB
fnp-3500	300	13	secondary	secondary	ADJ
fnp-3500	300	14	annotations	annotation	NOUN
fnp-3500	300	15	for	for	ADP
fnp-3500	300	16	mitotic	mitotic	ADJ
fnp-3500	300	17	figure	figure	NOUN
fnp-3500	300	18	look	look	NOUN
fnp-3500	300	19	-	-	PUNCT
fnp-3500	300	20	alikes	alike	NOUN
fnp-3500	300	21	.	.	PUNCT
fnp-3500	301	1	additionally	additionally	ADV
fnp-3500	301	2	to	to	ADP
fnp-3500	301	3	a	a	DET
fnp-3500	301	4	blinded	blind	VERB
fnp-3500	301	5	two	two	NUM
fnp-3500	301	6	-	-	PUNCT
fnp-3500	301	7	expert	expert	NOUN
fnp-3500	301	8	manual	manual	ADJ
fnp-3500	301	9	annotation	annotation	NOUN
fnp-3500	301	10	,	,	PUNCT
fnp-3500	301	11	we	we	PRON
fnp-3500	301	12	developed	develop	VERB
fnp-3500	301	13	an	an	DET
fnp-3500	301	14	algorithm	algorithm	NOUN
fnp-3500	301	15	-	-	PUNCT
fnp-3500	301	16	aided	aid	VERB
fnp-3500	301	17	dataset	dataset	NOUN
fnp-3500	301	18	,	,	PUNCT
fnp-3500	301	19	where	where	SCONJ
fnp-3500	301	20	potentially	potentially	ADV
fnp-3500	301	21	missed	miss	VERB
fnp-3500	301	22	mitotic	mitotic	ADJ
fnp-3500	301	23	figures	figure	NOUN
fnp-3500	301	24	were	be	AUX
fnp-3500	301	25	detected	detect	VERB
fnp-3500	301	26	by	by	ADP
fnp-3500	301	27	a	a	DET
fnp-3500	301	28	deep	deep	ADJ
fnp-3500	301	29	neural	neural	ADJ
fnp-3500	301	30	network	network	NOUN
fnp-3500	301	31	and	and	CCONJ
fnp-3500	301	32	subsequently	subsequently	ADV
fnp-3500	301	33	assessed	assess	VERB
fnp-3500	301	34	by	by	ADP
fnp-3500	301	35	a	a	DET
fnp-3500	301	36	human	human	ADJ
fnp-3500	301	37	expert	expert	NOUN
fnp-3500	301	38	.	.	PUNCT
fnp-3500	302	1	we	we	PRON
fnp-3500	302	2	used	use	VERB
fnp-3500	302	3	a	a	DET
fnp-3500	302	4	pretrained	pretraine	VERB
fnp-3500	302	5	deep	deep	ADJ
fnp-3500	302	6	-	-	PUNCT
fnp-3500	302	7	neuronal	neuronal	ADJ
fnp-3500	302	8	network	network	NOUN
fnp-3500	302	9	approach	approach	NOUN
fnp-3500	302	10	(	(	PUNCT
fnp-3500	302	11	retinanet	retinanet	NOUN
fnp-3500	302	12	)	)	PUNCT
fnp-3500	302	13	to	to	PART
fnp-3500	302	14	validate	validate	VERB
fnp-3500	302	15	our	our	PRON
fnp-3500	302	16	data	datum	NOUN
fnp-3500	302	17	set	set	VERB
fnp-3500	302	18	.	.	PUNCT
fnp-3500	303	1	finally	finally	ADV
fnp-3500	303	2	,	,	PUNCT
fnp-3500	303	3	a	a	DET
fnp-3500	303	4	plugin	plugin	NOUN
fnp-3500	303	5	for	for	ADP
fnp-3500	303	6	sliderunner	sliderunner	NOUN
fnp-3500	303	7	,	,	PUNCT
fnp-3500	303	8	an	an	DET
fnp-3500	303	9	open	open	ADJ
fnp-3500	303	10	-	-	PUNCT
fnp-3500	303	11	source	source	NOUN
fnp-3500	303	12	software	software	NOUN
fnp-3500	303	13	,	,	PUNCT
fnp-3500	303	14	was	be	AUX
fnp-3500	303	15	built	build	VERB
fnp-3500	303	16	for	for	ADP
fnp-3500	303	17	convenience	convenience	NOUN
fnp-3500	303	18	enabling	enable	VERB
fnp-3500	303	19	real	real	ADJ
fnp-3500	303	20	-	-	PUNCT
fnp-3500	303	21	time	time	NOUN
fnp-3500	303	22	identification	identification	NOUN
fnp-3500	303	23	of	of	ADP
fnp-3500	303	24	mitotic	mitotic	ADJ
fnp-3500	303	25	figures	figure	NOUN
fnp-3500	303	26	in	in	ADP
fnp-3500	303	27	virtual	virtual	ADJ
fnp-3500	303	28	slides	slide	NOUN
fnp-3500	303	29	.	.	PUNCT
fnp-3500	304	1	results	result	NOUN
fnp-3500	304	2	:	:	PUNCT
fnp-3500	304	3	out	out	ADP
fnp-3500	304	4	of	of	ADP
fnp-3500	304	5	69	69	NUM
fnp-3500	304	6	whole	whole	ADJ
fnp-3500	304	7	slide	slide	NOUN
fnp-3500	304	8	images	image	NOUN
fnp-3500	304	9	of	of	ADP
fnp-3500	304	10	the	the	DET
fnp-3500	304	11	complete	complete	ADJ
fnp-3500	304	12	data	datum	NOUN
fnp-3500	304	13	set	set	VERB
fnp-3500	304	14	,	,	PUNCT
fnp-3500	304	15	46	46	NUM
fnp-3500	304	16	were	be	AUX
fnp-3500	304	17	randomly	randomly	ADV
fnp-3500	304	18	assigned	assign	VERB
fnp-3500	304	19	to	to	ADP
fnp-3500	304	20	the	the	DET
fnp-3500	304	21	training	training	NOUN
fnp-3500	304	22	set	set	NOUN
fnp-3500	304	23	and	and	CCONJ
fnp-3500	304	24	23	23	NUM
fnp-3500	304	25	to	to	PART
fnp-3500	304	26	be	be	AUX
fnp-3500	304	27	the	the	DET
fnp-3500	304	28	test	test	NOUN
fnp-3500	304	29	set	set	VERB
fnp-3500	304	30	.	.	PUNCT
fnp-3500	305	1	a	a	DET
fnp-3500	305	2	preliminary	preliminary	ADJ
fnp-3500	305	3	evaluation	evaluation	NOUN
fnp-3500	305	4	yielded	yield	VERB
fnp-3500	305	5	an	an	DET
fnp-3500	305	6	f1	f1	ADJ
fnp-3500	305	7	score	score	NOUN
fnp-3500	305	8	of	of	ADP
fnp-3500	305	9	0.659	0.659	NUM
fnp-3500	305	10	.	.	PUNCT
fnp-3500	306	1	conclusion	conclusion	NOUN
fnp-3500	306	2	:	:	PUNCT
fnp-3500	306	3	error	error	NOUN
fnp-3500	306	4	-	-	PUNCT
fnp-3500	306	5	prone	prone	ADJ
fnp-3500	306	6	and	and	CCONJ
fnp-3500	306	7	tedious	tedious	ADJ
fnp-3500	306	8	mitotic	mitotic	ADJ
fnp-3500	306	9	figure	figure	NOUN
fnp-3500	306	10	counts	count	NOUN
fnp-3500	306	11	and	and	CCONJ
fnp-3500	306	12	region	region	NOUN
fnp-3500	306	13	of	of	ADP
fnp-3500	306	14	interest	interest	NOUN
fnp-3500	306	15	identification	identification	NOUN
fnp-3500	306	16	may	may	AUX
fnp-3500	306	17	be	be	AUX
fnp-3500	306	18	assisted	assist	VERB
fnp-3500	306	19	in	in	ADP
fnp-3500	306	20	the	the	DET
fnp-3500	306	21	future	future	NOUN
fnp-3500	306	22	with	with	ADP
fnp-3500	306	23	the	the	DET
fnp-3500	306	24	help	help	NOUN
fnp-3500	306	25	of	of	ADP
fnp-3500	306	26	modern	modern	ADJ
fnp-3500	306	27	deep	deep	ADJ
fnp-3500	306	28	learning	learning	NOUN
fnp-3500	306	29	algorithms	algorithm	NOUN
fnp-3500	306	30	integrated	integrate	VERB
fnp-3500	306	31	into	into	ADP
fnp-3500	306	32	a	a	DET
fnp-3500	306	33	user	user	NOUN
fnp-3500	306	34	-	-	PUNCT
fnp-3500	306	35	friendly	friendly	ADJ
fnp-3500	306	36	software	software	NOUN
fnp-3500	306	37	suite	suite	NOUN
fnp-3500	306	38	.	.	PUNCT
fnp-3500	306	39	  	  	SPACE
fnp-3500	307	1	pii-03	pii-03	NOUN
fnp-3500	307	2	free	free	ADJ
fnp-3500	307	3	neuropathol	neuropathol	NOUN
fnp-3500	307	4	2:22:35	2:22:35	NUM
fnp-3500	307	5	intracranial	intracranial	ADJ
fnp-3500	307	6	ependymoma	ependymoma	NOUN
fnp-3500	307	7	in	in	ADP
fnp-3500	307	8	adults	adult	NOUN
fnp-3500	307	9	,	,	PUNCT
fnp-3500	307	10	a	a	DET
fnp-3500	307	11	methylome	methylome	ADV
fnp-3500	307	12	-	-	PUNCT
fnp-3500	307	13	based	base	VERB
fnp-3500	307	14	analysis	analysis	NOUN
fnp-3500	307	15	m.	m.	NOUN
fnp-3500	307	16	träger1	träger1	PROPN
fnp-3500	307	17	,	,	PUNCT
fnp-3500	307	18	l.	l.	PROPN
fnp-3500	307	19	schweizer2,3	schweizer2,3	PROPN
fnp-3500	307	20	,	,	PUNCT
fnp-3500	307	21	p.	p.	NOUN
fnp-3500	307	22	vajkoczy4	vajkoczy4	PROPN
fnp-3500	307	23	,	,	PUNCT
fnp-3500	307	24	k.	k.	PROPN
fnp-3500	307	25	fukuoka5	fukuoka5	PROPN
fnp-3500	307	26	,	,	PUNCT
fnp-3500	307	27	k.	k.	PROPN
fnp-3500	307	28	ichimura5	ichimura5	PROPN
fnp-3500	307	29	,	,	PUNCT
fnp-3500	307	30	u.	u.	PROPN
fnp-3500	307	31	schüller6	schüller6	PROPN
fnp-3500	307	32	,	,	PUNCT
fnp-3500	307	33	l.	l.	PROPN
fnp-3500	307	34	dührsen7	dührsen7	PROPN
fnp-3500	307	35	,	,	PUNCT
fnp-3500	307	36	m.	m.	NOUN
fnp-3500	307	37	müther8	müther8	PROPN
fnp-3500	307	38	,	,	PUNCT
fnp-3500	307	39	w.	w.	NOUN
fnp-3500	307	40	paulus9	paulus9	PROPN
fnp-3500	307	41	,	,	PUNCT
fnp-3500	307	42	c.	c.	PROPN
fnp-3500	307	43	thomas9	thomas9	PROPN
fnp-3500	307	44	,	,	PUNCT
fnp-3500	307	45	j.	j.	PROPN
fnp-3500	307	46	schittenhelm10	schittenhelm10	PROPN
fnp-3500	307	47	,	,	PUNCT
fnp-3500	307	48	f.	f.	PROPN
fnp-3500	307	49	eckert11	eckert11	PROPN
fnp-3500	307	50	,	,	PUNCT
fnp-3500	307	51	k.	k.	PROPN
fnp-3500	307	52	m.	m.	PROPN
fnp-3500	307	53	niyazi12	niyazi12	PROPN
fnp-3500	307	54	,	,	PUNCT
fnp-3500	307	55	d.	d.	PROPN
fnp-3500	307	56	f.	f.	PROPN
fnp-3500	307	57	fleischmann12	fleischmann12	PROPN
fnp-3500	307	58	,	,	PUNCT
fnp-3500	307	59	m.	m.	NOUN
fnp-3500	307	60	dorostkar13	dorostkar13	NOUN
fnp-3500	307	61	,	,	PUNCT
fnp-3500	307	62	p.	p.	NOUN
fnp-3500	307	63	feyer14	feyer14	NOUN
fnp-3500	307	64	,	,	PUNCT
fnp-3500	307	65	s.	s.	PROPN
fnp-3500	307	66	a.	a.	PROPN
fnp-3500	307	67	may15	may15	PROPN
fnp-3500	307	68	,	,	PUNCT
fnp-3500	307	69	d.	d.	PROPN
fnp-3500	307	70	moskopp16	moskopp16	PROPN
fnp-3500	307	71	,	,	PUNCT
fnp-3500	307	72	h.	h.	PROPN
fnp-3500	307	73	badakhshi17	badakhshi17	PROPN
fnp-3500	307	74	,	,	PUNCT
fnp-3500	307	75	s.	s.	PROPN
fnp-3500	307	76	wecker17	wecker17	PROPN
fnp-3500	307	77	,	,	PUNCT
fnp-3500	307	78	c.	c.	PROPN
fnp-3500	307	79	radke18	radke18	PROPN
fnp-3500	307	80	,	,	PUNCT
fnp-3500	307	81	j.	j.	PROPN
fnp-3500	307	82	walter19	walter19	PROPN
fnp-3500	307	83	,	,	PUNCT
fnp-3500	307	84	d.	d.	PROPN
fnp-3500	307	85	capper2,3	capper2,3	PROPN
fnp-3500	307	86	,	,	PUNCT
fnp-3500	307	87	d.	d.	PROPN
fnp-3500	307	88	kaul1,3	kaul1,3	PROPN
fnp-3500	307	89	1	1	NUM
fnp-3500	307	90	charité	charité	PROPN
fnp-3500	307	91	–	–	PUNCT
fnp-3500	307	92	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	307	93	berlin	berlin	PROPN
fnp-3500	307	94	,	,	PUNCT
fnp-3500	307	95	department	department	NOUN
fnp-3500	307	96	of	of	ADP
fnp-3500	307	97	radiation	radiation	NOUN
fnp-3500	307	98	oncology	oncology	NOUN
fnp-3500	307	99	,	,	PUNCT
fnp-3500	307	100	berlin	berlin	PROPN
fnp-3500	307	101	,	,	PUNCT
fnp-3500	307	102	germany	germany	PROPN
fnp-3500	307	103	2	2	NUM
fnp-3500	307	104	charité	charité	PROPN
fnp-3500	307	105	–	–	PUNCT
fnp-3500	307	106	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	307	107	berlin	berlin	PROPN
fnp-3500	307	108	,	,	PUNCT
fnp-3500	307	109	department	department	NOUN
fnp-3500	307	110	of	of	ADP
fnp-3500	307	111	neuropathology	neuropathology	NOUN
fnp-3500	307	112	,	,	PUNCT
fnp-3500	307	113	berlin	berlin	PROPN
fnp-3500	307	114	,	,	PUNCT
fnp-3500	307	115	germany	germany	PROPN
fnp-3500	307	116	3	3	NUM
fnp-3500	307	117	german	german	ADJ
fnp-3500	307	118	cancer	cancer	NOUN
fnp-3500	307	119	consortium	consortium	NOUN
fnp-3500	307	120	(	(	PUNCT
fnp-3500	307	121	dktk	dktk	NOUN
fnp-3500	307	122	)	)	PUNCT
fnp-3500	307	123	,	,	PUNCT
fnp-3500	307	124	partner	partner	NOUN
fnp-3500	307	125	site	site	NOUN
fnp-3500	307	126	berlin	berlin	PROPN
fnp-3500	307	127	,	,	PUNCT
fnp-3500	307	128	german	german	ADJ
fnp-3500	307	129	cancer	cancer	NOUN
fnp-3500	307	130	research	research	NOUN
fnp-3500	307	131	center	center	NOUN
fnp-3500	307	132	(	(	PUNCT
fnp-3500	307	133	dkfz	dkfz	PROPN
fnp-3500	307	134	)	)	PUNCT
fnp-3500	307	135	,	,	PUNCT
fnp-3500	307	136	heidelberg	heidelberg	PROPN
fnp-3500	307	137	,	,	PUNCT
fnp-3500	307	138	germany	germany	PROPN
fnp-3500	307	139	4	4	NUM
fnp-3500	307	140	charité	charité	PROPN
fnp-3500	307	141	–	–	PUNCT
fnp-3500	307	142	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	307	143	berlin	berlin	PROPN
fnp-3500	307	144	,	,	PUNCT
fnp-3500	307	145	department	department	NOUN
fnp-3500	307	146	of	of	ADP
fnp-3500	307	147	neurosurgery	neurosurgery	NOUN
fnp-3500	307	148	,	,	PUNCT
fnp-3500	307	149	berlin	berlin	PROPN
fnp-3500	307	150	,	,	PUNCT
fnp-3500	307	151	germany	germany	PROPN
fnp-3500	307	152	5	5	NUM
fnp-3500	307	153	national	national	ADJ
fnp-3500	307	154	cancer	cancer	NOUN
fnp-3500	307	155	center	center	PROPN
fnp-3500	307	156	research	research	PROPN
fnp-3500	307	157	institute	institute	PROPN
fnp-3500	307	158	,	,	PUNCT
fnp-3500	307	159	division	division	NOUN
fnp-3500	307	160	of	of	ADP
fnp-3500	307	161	brain	brain	NOUN
fnp-3500	307	162	tumor	tumor	NOUN
fnp-3500	307	163	translational	translational	ADJ
fnp-3500	307	164	research	research	NOUN
fnp-3500	307	165	,	,	PUNCT
fnp-3500	307	166	tokyo	tokyo	PROPN
fnp-3500	307	167	,	,	PUNCT
fnp-3500	307	168	japan	japan	PROPN
fnp-3500	307	169	6	6	NUM
fnp-3500	307	170	university	university	PROPN
fnp-3500	307	171	medical	medical	ADJ
fnp-3500	307	172	center	center	PROPN
fnp-3500	307	173	hamburg	hamburg	PROPN
fnp-3500	307	174	-	-	PUNCT
fnp-3500	307	175	eppendorf	eppendorf	PROPN
fnp-3500	307	176	,	,	PUNCT
fnp-3500	307	177	institute	institute	NOUN
fnp-3500	307	178	of	of	ADP
fnp-3500	307	179	neuropathology	neuropathology	NOUN
fnp-3500	307	180	,	,	PUNCT
fnp-3500	307	181	hamburg	hamburg	PROPN
fnp-3500	307	182	,	,	PUNCT
fnp-3500	307	183	germany	germany	PROPN
fnp-3500	307	184	7	7	NUM
fnp-3500	307	185	university	university	PROPN
fnp-3500	307	186	medical	medical	ADJ
fnp-3500	307	187	center	center	PROPN
fnp-3500	307	188	hamburg	hamburg	PROPN
fnp-3500	307	189	-	-	PUNCT
fnp-3500	307	190	eppendorf	eppendorf	PROPN
fnp-3500	307	191	,	,	PUNCT
fnp-3500	307	192	department	department	NOUN
fnp-3500	307	193	of	of	ADP
fnp-3500	307	194	neurosurgery	neurosurgery	NOUN
fnp-3500	307	195	,	,	PUNCT
fnp-3500	307	196	hamburg	hamburg	PROPN
fnp-3500	307	197	,	,	PUNCT
fnp-3500	307	198	germany	germany	PROPN
fnp-3500	307	199	8	8	NUM
fnp-3500	307	200	university	university	NOUN
fnp-3500	307	201	hospital	hospital	NOUN
fnp-3500	307	202	münster	münster	NOUN
fnp-3500	307	203	,	,	PUNCT
fnp-3500	307	204	department	department	NOUN
fnp-3500	307	205	of	of	ADP
fnp-3500	307	206	neurosurgery	neurosurgery	NOUN
fnp-3500	307	207	,	,	PUNCT
fnp-3500	307	208	münster	münster	NOUN
fnp-3500	307	209	,	,	PUNCT
fnp-3500	307	210	germany	germany	PROPN
fnp-3500	307	211	9	9	NUM
fnp-3500	307	212	university	university	NOUN
fnp-3500	307	213	hospital	hospital	NOUN
fnp-3500	307	214	münster	münster	NOUN
fnp-3500	307	215	,	,	PUNCT
fnp-3500	307	216	institute	institute	NOUN
fnp-3500	307	217	of	of	ADP
fnp-3500	307	218	neuropathology	neuropathology	NOUN
fnp-3500	307	219	,	,	PUNCT
fnp-3500	307	220	münster	münster	PROPN
fnp-3500	307	221	,	,	PUNCT
fnp-3500	307	222	germany	germany	PROPN
fnp-3500	307	223	10	10	NUM
fnp-3500	307	224	university	university	PROPN
fnp-3500	307	225	hospital	hospital	NOUN
fnp-3500	307	226	tübingen	tübingen	PROPN
fnp-3500	307	227	,	,	PUNCT
fnp-3500	307	228	department	department	NOUN
fnp-3500	307	229	of	of	ADP
fnp-3500	307	230	neuropathology	neuropathology	NOUN
fnp-3500	307	231	,	,	PUNCT
fnp-3500	307	232	tübingen	tübingen	PROPN
fnp-3500	307	233	,	,	PUNCT
fnp-3500	307	234	germany	germany	PROPN
fnp-3500	307	235	11	11	NUM
fnp-3500	307	236	university	university	PROPN
fnp-3500	307	237	hospital	hospital	NOUN
fnp-3500	307	238	tübingen	tübingen	PROPN
fnp-3500	307	239	,	,	PUNCT
fnp-3500	307	240	department	department	NOUN
fnp-3500	307	241	of	of	ADP
fnp-3500	307	242	radiation	radiation	NOUN
fnp-3500	307	243	oncology	oncology	NOUN
fnp-3500	307	244	,	,	PUNCT
fnp-3500	307	245	tübingen	tübingen	PROPN
fnp-3500	307	246	,	,	PUNCT
fnp-3500	307	247	germany	germany	PROPN
fnp-3500	307	248	12	12	NUM
fnp-3500	307	249	university	university	NOUN
fnp-3500	307	250	hospital	hospital	NOUN
fnp-3500	307	251	,	,	PUNCT
fnp-3500	307	252	lmu	lmu	PROPN
fnp-3500	307	253	munich	munich	PROPN
fnp-3500	307	254	,	,	PUNCT
fnp-3500	307	255	department	department	NOUN
fnp-3500	307	256	of	of	ADP
fnp-3500	307	257	radiation	radiation	NOUN
fnp-3500	307	258	oncology	oncology	NOUN
fnp-3500	307	259	,	,	PUNCT
fnp-3500	307	260	münchen	münchen	PROPN
fnp-3500	307	261	,	,	PUNCT
fnp-3500	307	262	germany	germany	PROPN
fnp-3500	307	263	13	13	NUM
fnp-3500	307	264	ludwig	ludwig	PROPN
fnp-3500	307	265	-	-	PUNCT
fnp-3500	307	266	maximilians	maximilians	PROPN
fnp-3500	307	267	-	-	PUNCT
fnp-3500	307	268	university	university	NOUN
fnp-3500	307	269	munich	munich	PROPN
fnp-3500	307	270	,	,	PUNCT
fnp-3500	307	271	center	center	NOUN
fnp-3500	307	272	for	for	ADP
fnp-3500	307	273	neuropathology	neuropathology	NOUN
fnp-3500	307	274	,	,	PUNCT
fnp-3500	307	275	münchen	münchen	PROPN
fnp-3500	307	276	,	,	PUNCT
fnp-3500	307	277	germany	germany	PROPN
fnp-3500	307	278	14	14	NUM
fnp-3500	307	279	vivantes	vivante	NOUN
fnp-3500	307	280	hospital	hospital	NOUN
fnp-3500	307	281	neukölln	neukölln	PROPN
fnp-3500	307	282	,	,	PUNCT
fnp-3500	307	283	berlin	berlin	PROPN
fnp-3500	307	284	,	,	PUNCT
fnp-3500	307	285	germany	germany	PROPN
fnp-3500	307	286	15	15	NUM
fnp-3500	307	287	klinikum	klinikum	PROPN
fnp-3500	307	288	chemnitz	chemnitz	PROPN
fnp-3500	307	289	,	,	PUNCT
fnp-3500	307	290	department	department	NOUN
fnp-3500	307	291	of	of	ADP
fnp-3500	307	292	neurosurgery	neurosurgery	NOUN
fnp-3500	307	293	,	,	PUNCT
fnp-3500	307	294	chemnitz	chemnitz	PROPN
fnp-3500	307	295	,	,	PUNCT
fnp-3500	307	296	germany	germany	PROPN
fnp-3500	307	297	16	16	NUM
fnp-3500	307	298	vivantes	vivante	NOUN
fnp-3500	307	299	klinikum	klinikum	VERB
fnp-3500	308	1	i	i	PRON
fnp-3500	308	2	m	m	VERB
fnp-3500	308	3	friedrichshain	friedrichshain	VERB
fnp-3500	308	4	,	,	PUNCT
fnp-3500	308	5	department	department	NOUN
fnp-3500	308	6	of	of	ADP
fnp-3500	308	7	neurosurgery	neurosurgery	NOUN
fnp-3500	308	8	,	,	PUNCT
fnp-3500	308	9	berlin	berlin	PROPN
fnp-3500	308	10	,	,	PUNCT
fnp-3500	308	11	germany	germany	PROPN
fnp-3500	308	12	17	17	NUM
fnp-3500	308	13	ernst	ernst	PROPN
fnp-3500	308	14	von	von	PROPN
fnp-3500	308	15	bergmann	bergmann	PROPN
fnp-3500	308	16	medical	medical	PROPN
fnp-3500	308	17	center	center	PROPN
fnp-3500	308	18	,	,	PUNCT
fnp-3500	308	19	academic	academic	ADJ
fnp-3500	308	20	teaching	teaching	NOUN
fnp-3500	308	21	hospital	hospital	NOUN
fnp-3500	308	22	of	of	ADP
fnp-3500	308	23	humboldt	humboldt	PROPN
fnp-3500	308	24	university	university	PROPN
fnp-3500	308	25	berlin	berlin	PROPN
fnp-3500	308	26	(	(	PUNCT
fnp-3500	308	27	charité	charité	PROPN
fnp-3500	308	28	)	)	PUNCT
fnp-3500	308	29	,	,	PUNCT
fnp-3500	308	30	department	department	NOUN
fnp-3500	308	31	of	of	ADP
fnp-3500	308	32	clinical	clinical	ADJ
fnp-3500	308	33	radiation	radiation	NOUN
fnp-3500	308	34	oncology	oncology	NOUN
fnp-3500	308	35	,	,	PUNCT
fnp-3500	308	36	potsdam	potsdam	PROPN
fnp-3500	308	37	,	,	PUNCT
fnp-3500	308	38	germany	germany	PROPN
fnp-3500	308	39	18	18	NUM
fnp-3500	308	40	ernst	ernst	PROPN
fnp-3500	308	41	von	von	PROPN
fnp-3500	308	42	bergmann	bergmann	PROPN
fnp-3500	308	43	medical	medical	PROPN
fnp-3500	308	44	center	center	PROPN
fnp-3500	308	45	,	,	PUNCT
fnp-3500	308	46	academic	academic	ADJ
fnp-3500	308	47	teaching	teaching	NOUN
fnp-3500	308	48	hospital	hospital	NOUN
fnp-3500	308	49	of	of	ADP
fnp-3500	308	50	humboldt	humboldt	PROPN
fnp-3500	308	51	university	university	PROPN
fnp-3500	308	52	berlin	berlin	PROPN
fnp-3500	308	53	(	(	PUNCT
fnp-3500	308	54	charité	charité	PROPN
fnp-3500	308	55	)	)	PUNCT
fnp-3500	308	56	,	,	PUNCT
fnp-3500	308	57	department	department	NOUN
fnp-3500	308	58	of	of	ADP
fnp-3500	308	59	pathology	pathology	PROPN
fnp-3500	308	60	,	,	PUNCT
fnp-3500	308	61	potsdam	potsdam	PROPN
fnp-3500	308	62	,	,	PUNCT
fnp-3500	308	63	germany	germany	PROPN
fnp-3500	308	64	19	19	NUM
fnp-3500	308	65	medical	medical	ADJ
fnp-3500	308	66	center	center	NOUN
fnp-3500	308	67	saarbruecken	saarbruecken	VERB
fnp-3500	308	68	,	,	PUNCT
fnp-3500	308	69	department	department	NOUN
fnp-3500	308	70	of	of	ADP
fnp-3500	308	71	neurosurgery	neurosurgery	NOUN
fnp-3500	308	72	,	,	PUNCT
fnp-3500	308	73	saarbrücken	saarbrücken	VERB
fnp-3500	308	74	,	,	PUNCT
fnp-3500	308	75	germany	germany	PROPN
fnp-3500	308	76	introduction	introduction	NOUN
fnp-3500	308	77	:	:	PUNCT
fnp-3500	308	78	recently	recently	ADV
fnp-3500	308	79	dna	dna	PROPN
fnp-3500	308	80	methylation	methylation	NOUN
fnp-3500	308	81	profiling	profiling	NOUN
fnp-3500	308	82	became	became	AUX
fnp-3500	308	83	widely	widely	ADV
fnp-3500	308	84	accepted	accept	VERB
fnp-3500	308	85	as	as	ADP
fnp-3500	308	86	a	a	DET
fnp-3500	308	87	method	method	NOUN
fnp-3500	308	88	to	to	PART
fnp-3500	308	89	identify	identify	VERB
fnp-3500	308	90	biologically	biologically	ADV
fnp-3500	308	91	distinct	distinct	ADJ
fnp-3500	308	92	subgroups	subgroup	NOUN
fnp-3500	308	93	of	of	ADP
fnp-3500	308	94	ependymoma	ependymoma	NOUN
fnp-3500	308	95	.	.	PUNCT
fnp-3500	309	1	however	however	ADV
fnp-3500	309	2	,	,	PUNCT
fnp-3500	309	3	due	due	ADP
fnp-3500	309	4	to	to	ADP
fnp-3500	309	5	the	the	DET
fnp-3500	309	6	rarity	rarity	NOUN
fnp-3500	309	7	of	of	ADP
fnp-3500	309	8	these	these	DET
fnp-3500	309	9	tumors	tumor	NOUN
fnp-3500	309	10	in	in	ADP
fnp-3500	309	11	adults	adult	NOUN
fnp-3500	309	12	,	,	PUNCT
fnp-3500	309	13	previous	previous	ADJ
fnp-3500	309	14	studies	study	NOUN
fnp-3500	309	15	have	have	AUX
fnp-3500	309	16	failed	fail	VERB
fnp-3500	309	17	to	to	PART
fnp-3500	309	18	achieve	achieve	VERB
fnp-3500	309	19	a	a	DET
fnp-3500	309	20	sufficient	sufficient	ADJ
fnp-3500	309	21	number	number	NOUN
fnp-3500	309	22	of	of	ADP
fnp-3500	309	23	patients	patient	NOUN
fnp-3500	309	24	to	to	PART
fnp-3500	309	25	characterize	characterize	VERB
fnp-3500	309	26	the	the	DET
fnp-3500	309	27	landscape	landscape	NOUN
fnp-3500	309	28	of	of	ADP
fnp-3500	309	29	dna	dna	PROPN
fnp-3500	309	30	methylation	methylation	NOUN
fnp-3500	309	31	profiles	profile	NOUN
fnp-3500	309	32	,	,	PUNCT
fnp-3500	309	33	their	their	PRON
fnp-3500	309	34	clinical	clinical	ADJ
fnp-3500	309	35	characteristics	characteristic	NOUN
fnp-3500	309	36	and	and	CCONJ
fnp-3500	309	37	prognosis	prognosis	NOUN
fnp-3500	309	38	in	in	ADP
fnp-3500	309	39	this	this	DET
fnp-3500	309	40	age	age	NOUN
fnp-3500	309	41	group	group	NOUN
fnp-3500	309	42	.	.	PUNCT
fnp-3500	310	1	objectives	objective	NOUN
fnp-3500	310	2	:	:	PUNCT
fnp-3500	310	3	we	we	PRON
fnp-3500	310	4	investigated	investigate	VERB
fnp-3500	310	5	dna	dna	PROPN
fnp-3500	310	6	methylation	methylation	NOUN
fnp-3500	310	7	profiles	profile	NOUN
fnp-3500	310	8	of	of	ADP
fnp-3500	310	9	adult	adult	NOUN
fnp-3500	310	10	intracranial	intracranial	ADJ
fnp-3500	310	11	ependymoma	ependymoma	NOUN
fnp-3500	310	12	collected	collect	VERB
fnp-3500	310	13	from	from	ADP
fnp-3500	310	14	12	12	NUM
fnp-3500	310	15	different	different	ADJ
fnp-3500	310	16	centers	center	NOUN
fnp-3500	310	17	and	and	CCONJ
fnp-3500	310	18	sought	seek	VERB
fnp-3500	310	19	to	to	PART
fnp-3500	310	20	correlate	correlate	VERB
fnp-3500	310	21	molecular	molecular	ADJ
fnp-3500	310	22	subgroups	subgroup	NOUN
fnp-3500	310	23	to	to	ADP
fnp-3500	310	24	clinical	clinical	ADJ
fnp-3500	310	25	characteristics	characteristic	NOUN
fnp-3500	310	26	and	and	CCONJ
fnp-3500	310	27	outcome	outcome	NOUN
fnp-3500	310	28	.	.	PUNCT
fnp-3500	311	1	materials	material	NOUN
fnp-3500	311	2	and	and	CCONJ
fnp-3500	311	3	methods	method	NOUN
fnp-3500	311	4	:	:	PUNCT
fnp-3500	311	5	tumors	tumor	NOUN
fnp-3500	311	6	from	from	ADP
fnp-3500	311	7	157	157	NUM
fnp-3500	311	8	adult	adult	NOUN
fnp-3500	311	9	patients	patient	NOUN
fnp-3500	311	10	histologically	histologically	ADV
fnp-3500	311	11	classified	classify	VERB
fnp-3500	311	12	as	as	SCONJ
fnp-3500	311	13	who	who	PRON
fnp-3500	311	14	grade	grade	NOUN
fnp-3500	311	15	ii	ii	PROPN
fnp-3500	311	16	or	or	CCONJ
fnp-3500	311	17	iii	iii	NUM
fnp-3500	311	18	intracranial	intracranial	ADJ
fnp-3500	311	19	ependymoma	ependymoma	NOUN
fnp-3500	311	20	between	between	ADP
fnp-3500	311	21	1990	1990	NUM
fnp-3500	311	22	and	and	CCONJ
fnp-3500	311	23	2020	2020	NUM
fnp-3500	311	24	were	be	AUX
fnp-3500	311	25	subjected	subject	VERB
fnp-3500	311	26	to	to	ADP
fnp-3500	311	27	dna	dna	PROPN
fnp-3500	311	28	methylation	methylation	NOUN
fnp-3500	311	29	profiling	profiling	NOUN
fnp-3500	311	30	using	use	VERB
fnp-3500	311	31	the	the	DET
fnp-3500	311	32	illumina	illumina	PROPN
fnp-3500	311	33	human	human	PROPN
fnp-3500	311	34	methylation	methylation	PROPN
fnp-3500	311	35	450k	450k	PROPN
fnp-3500	311	36	or	or	CCONJ
fnp-3500	311	37	epic	epic	ADJ
fnp-3500	311	38	bead	bead	NOUN
fnp-3500	311	39	chip	chip	NOUN
fnp-3500	311	40	platform	platform	NOUN
fnp-3500	311	41	.	.	PUNCT
fnp-3500	312	1	profiles	profile	NOUN
fnp-3500	312	2	were	be	AUX
fnp-3500	312	3	matched	match	VERB
fnp-3500	312	4	with	with	ADP
fnp-3500	312	5	the	the	DET
fnp-3500	312	6	dkfz	dkfz	ADJ
fnp-3500	312	7	brain	brain	NOUN
fnp-3500	312	8	tumor	tumor	NOUN
fnp-3500	312	9	classifier	classifier	NOUN
fnp-3500	312	10	and	and	CCONJ
fnp-3500	312	11	detected	detect	VERB
fnp-3500	312	12	molecular	molecular	ADJ
fnp-3500	312	13	subgroups	subgroup	NOUN
fnp-3500	312	14	were	be	AUX
fnp-3500	312	15	correlated	correlate	VERB
fnp-3500	312	16	with	with	ADP
fnp-3500	312	17	overall	overall	ADJ
fnp-3500	312	18	survival	survival	NOUN
fnp-3500	312	19	(	(	PUNCT
fnp-3500	312	20	os	os	NOUN
fnp-3500	312	21	)	)	PUNCT
fnp-3500	312	22	and	and	CCONJ
fnp-3500	312	23	progression	progression	NOUN
fnp-3500	312	24	free	free	ADJ
fnp-3500	312	25	-	-	PUNCT
fnp-3500	312	26	survival	survival	NOUN
fnp-3500	312	27	(	(	PUNCT
fnp-3500	312	28	pfs	pfs	PROPN
fnp-3500	312	29	)	)	PUNCT
fnp-3500	312	30	.	.	PUNCT
fnp-3500	313	1	results	result	NOUN
fnp-3500	313	2	:	:	PUNCT
fnp-3500	313	3	in	in	ADP
fnp-3500	313	4	68.8	68.8	NUM
fnp-3500	313	5	%	%	NOUN
fnp-3500	313	6	(	(	PUNCT
fnp-3500	313	7	108/157	108/157	NUM
fnp-3500	313	8	)	)	PUNCT
fnp-3500	313	9	of	of	ADP
fnp-3500	313	10	cases	case	NOUN
fnp-3500	313	11	,	,	PUNCT
fnp-3500	313	12	the	the	DET
fnp-3500	313	13	suggested	suggest	VERB
fnp-3500	313	14	methylation	methylation	NOUN
fnp-3500	313	15	class	class	NOUN
fnp-3500	313	16	confirmed	confirm	VERB
fnp-3500	313	17	diagnosis	diagnosis	NOUN
fnp-3500	313	18	of	of	ADP
fnp-3500	313	19	an	an	DET
fnp-3500	313	20	ependymal	ependymal	ADJ
fnp-3500	313	21	tumor	tumor	NOUN
fnp-3500	313	22	with	with	ADP
fnp-3500	313	23	the	the	DET
fnp-3500	313	24	additional	additional	ADJ
fnp-3500	313	25	assignment	assignment	NOUN
fnp-3500	313	26	of	of	ADP
fnp-3500	313	27	a	a	DET
fnp-3500	313	28	molecular	molecular	ADJ
fnp-3500	313	29	subgroup	subgroup	NOUN
fnp-3500	313	30	(	(	PUNCT
fnp-3500	313	31	49	49	NUM
fnp-3500	313	32	pfb	pfb	NOUN
fnp-3500	313	33	,	,	PUNCT
fnp-3500	313	34	36	36	NUM
fnp-3500	313	35	se	se	X
fnp-3500	313	36	,	,	PUNCT
fnp-3500	313	37	17	17	NUM
fnp-3500	313	38	rela	rela	ADJ
fnp-3500	313	39	,	,	PUNCT
fnp-3500	313	40	3	3	NUM
fnp-3500	313	41	pfa	pfa	NOUN
fnp-3500	313	42	,	,	PUNCT
fnp-3500	313	43	2	2	NUM
fnp-3500	313	44	spinal	spinal	NOUN
fnp-3500	313	45	epn	epn	PROPN
fnp-3500	313	46	and1	and1	PROPN
fnp-3500	313	47	myxopapillary	myxopapillary	PROPN
fnp-3500	313	48	epn	epn	PROPN
fnp-3500	313	49	)	)	PUNCT
fnp-3500	313	50	whereas	whereas	SCONJ
fnp-3500	313	51	5.7	5.7	NUM
fnp-3500	313	52	%	%	NOUN
fnp-3500	313	53	(	(	PUNCT
fnp-3500	313	54	9/157	9/157	NOUN
fnp-3500	313	55	)	)	PUNCT
fnp-3500	313	56	were	be	AUX
fnp-3500	313	57	not	not	PART
fnp-3500	313	58	compatible	compatible	ADJ
fnp-3500	313	59	with	with	ADP
fnp-3500	313	60	the	the	DET
fnp-3500	313	61	initial	initial	ADJ
fnp-3500	313	62	diagnosis	diagnosis	NOUN
fnp-3500	313	63	of	of	ADP
fnp-3500	313	64	ependymoma	ependymoma	NOUN
fnp-3500	313	65	.	.	PUNCT
fnp-3500	314	1	the	the	DET
fnp-3500	314	2	remaining	remain	VERB
fnp-3500	314	3	25.5	25.5	NUM
fnp-3500	314	4	%	%	NOUN
fnp-3500	314	5	(	(	PUNCT
fnp-3500	314	6	40/157	40/157	NOUN
fnp-3500	314	7	)	)	PUNCT
fnp-3500	314	8	did	do	AUX
fnp-3500	314	9	not	not	PART
fnp-3500	314	10	reach	reach	VERB
fnp-3500	314	11	a	a	DET
fnp-3500	314	12	calibrated	calibrate	VERB
fnp-3500	314	13	score	score	NOUN
fnp-3500	314	14	≥0.9	≥0.9	PROPN
fnp-3500	314	15	and	and	CCONJ
fnp-3500	314	16	were	be	AUX
fnp-3500	314	17	considered	consider	VERB
fnp-3500	314	18	not	not	PART
fnp-3500	314	19	classifiable	classifiable	ADJ
fnp-3500	314	20	.	.	PUNCT
fnp-3500	315	1	median	median	ADJ
fnp-3500	315	2	follow	follow	NOUN
fnp-3500	315	3	-	-	PUNCT
fnp-3500	315	4	up	up	NOUN
fnp-3500	315	5	was	be	AUX
fnp-3500	315	6	54	54	NUM
fnp-3500	315	7	months	month	NOUN
fnp-3500	315	8	.	.	PUNCT
fnp-3500	316	1	five	five	NUM
fnp-3500	316	2	and	and	CCONJ
fnp-3500	316	3	10	10	NUM
fnp-3500	316	4	-	-	PUNCT
fnp-3500	316	5	year	year	NOUN
fnp-3500	316	6	pfs	pfs	PROPN
fnp-3500	316	7	rates	rate	NOUN
fnp-3500	316	8	were	be	AUX
fnp-3500	316	9	54.1	54.1	NUM
fnp-3500	316	10	%	%	NOUN
fnp-3500	316	11	and	and	CCONJ
fnp-3500	316	12	40.6	40.6	NUM
fnp-3500	316	13	%	%	NOUN
fnp-3500	316	14	for	for	ADP
fnp-3500	316	15	se	se	X
fnp-3500	316	16	,	,	PUNCT
fnp-3500	316	17	65.2	65.2	NUM
fnp-3500	316	18	%	%	NOUN
fnp-3500	316	19	and	and	CCONJ
fnp-3500	316	20	37.1	37.1	NUM
fnp-3500	316	21	%	%	NOUN
fnp-3500	316	22	for	for	ADP
fnp-3500	316	23	pf	pf	NOUN
fnp-3500	316	24	-	-	PUNCT
fnp-3500	316	25	b	b	NOUN
fnp-3500	316	26	,	,	PUNCT
fnp-3500	316	27	49	49	NUM
fnp-3500	316	28	%	%	NOUN
fnp-3500	316	29	and	and	CCONJ
fnp-3500	316	30	49	49	NUM
fnp-3500	316	31	%	%	NOUN
fnp-3500	316	32	for	for	ADP
fnp-3500	316	33	rela	rela	ADJ
fnp-3500	316	34	tumors	tumor	NOUN
fnp-3500	316	35	.	.	PUNCT
fnp-3500	317	1	the	the	DET
fnp-3500	317	2	5and	5and	NUM
fnp-3500	317	3	10	10	NUM
fnp-3500	317	4	-	-	PUNCT
fnp-3500	317	5	year	year	NOUN
fnp-3500	317	6	os	os	NOUN
fnp-3500	317	7	rates	rate	NOUN
fnp-3500	317	8	were	be	AUX
fnp-3500	317	9	70.1	70.1	NUM
fnp-3500	317	10	%	%	NOUN
fnp-3500	317	11	and	and	CCONJ
fnp-3500	317	12	49.1%for	49.1%for	NUM
fnp-3500	317	13	se	se	X
fnp-3500	317	14	,	,	PUNCT
fnp-3500	317	15	95.4	95.4	NUM
fnp-3500	317	16	%	%	NOUN
fnp-3500	317	17	and	and	CCONJ
fnp-3500	317	18	85.5	85.5	NUM
fnp-3500	317	19	%	%	NOUN
fnp-3500	317	20	for	for	ADP
fnp-3500	317	21	pf	pf	NOUN
fnp-3500	317	22	-	-	PUNCT
fnp-3500	317	23	b	b	NOUN
fnp-3500	317	24	and	and	CCONJ
fnp-3500	317	25	100	100	NUM
fnp-3500	317	26	%	%	NOUN
fnp-3500	317	27	and	and	CCONJ
fnp-3500	317	28	75	75	NUM
fnp-3500	317	29	%	%	NOUN
fnp-3500	317	30	for	for	ADP
fnp-3500	317	31	rela	rela	ADJ
fnp-3500	317	32	tumors	tumor	NOUN
fnp-3500	317	33	.	.	PUNCT
fnp-3500	318	1	conclusion	conclusion	NOUN
fnp-3500	318	2	:	:	PUNCT
fnp-3500	318	3	this	this	DET
fnp-3500	318	4	cohort	cohort	NOUN
fnp-3500	318	5	of	of	ADP
fnp-3500	318	6	adult	adult	NOUN
fnp-3500	318	7	intracranial	intracranial	ADJ
fnp-3500	318	8	ependymoma	ependymoma	NOUN
fnp-3500	318	9	comprises	comprise	VERB
fnp-3500	318	10	various	various	ADJ
fnp-3500	318	11	molecular	molecular	ADJ
fnp-3500	318	12	subgroups	subgroup	NOUN
fnp-3500	318	13	and	and	CCONJ
fnp-3500	318	14	even	even	ADV
fnp-3500	318	15	different	different	ADJ
fnp-3500	318	16	tumor	tumor	NOUN
fnp-3500	318	17	entities	entity	NOUN
fnp-3500	318	18	.	.	PUNCT
fnp-3500	319	1	most	most	ADJ
fnp-3500	319	2	patients	patient	NOUN
fnp-3500	319	3	with	with	ADP
fnp-3500	319	4	ependymal	ependymal	ADJ
fnp-3500	319	5	tumors	tumor	NOUN
fnp-3500	319	6	confirmed	confirm	VERB
fnp-3500	319	7	by	by	ADP
fnp-3500	319	8	dna	dna	PROPN
fnp-3500	319	9	methylation	methylation	NOUN
fnp-3500	319	10	profiling	profiling	NOUN
fnp-3500	319	11	show	show	VERB
fnp-3500	319	12	a	a	DET
fnp-3500	319	13	favorable	favorable	ADJ
fnp-3500	319	14	prognosis	prognosis	NOUN
fnp-3500	319	15	.	.	PUNCT
fnp-3500	320	1	however	however	ADV
fnp-3500	320	2	,	,	PUNCT
fnp-3500	320	3	factors	factor	NOUN
fnp-3500	320	4	that	that	PRON
fnp-3500	320	5	affect	affect	VERB
fnp-3500	320	6	survival	survival	NOUN
fnp-3500	320	7	need	need	VERB
fnp-3500	320	8	to	to	PART
fnp-3500	320	9	be	be	AUX
fnp-3500	320	10	determined	determine	VERB
fnp-3500	320	11	.	.	PUNCT
fnp-3500	320	12	  	  	SPACE
fnp-3500	321	1	poster	poster	NOUN
fnp-3500	321	2	session	session	NOUN
fnp-3500	321	3	iii	iii	X
fnp-3500	321	4	–	–	PUNCT
fnp-3500	321	5	muscle	muscle	NOUN
fnp-3500	321	6	&	&	CCONJ
fnp-3500	321	7	nerve	nerve	NOUN
fnp-3500	321	8	piii-01	piii-01	ADJ
fnp-3500	321	9	free	free	ADJ
fnp-3500	321	10	neuropathol	neuropathol	NOUN
fnp-3500	321	11	2:22:37	2:22:37	NUM
fnp-3500	321	12	imaging	imaging	NOUN
fnp-3500	321	13	of	of	ADP
fnp-3500	321	14	extended	extended	ADJ
fnp-3500	321	15	tissue	tissue	NOUN
fnp-3500	321	16	areas	area	NOUN
fnp-3500	321	17	by	by	ADP
fnp-3500	321	18	automated	automate	VERB
fnp-3500	321	19	large	large	ADJ
fnp-3500	321	20	-	-	PUNCT
fnp-3500	321	21	scale	scale	NOUN
fnp-3500	321	22	electron	electron	NOUN
fnp-3500	321	23	microscopy	microscopy	NOUN
fnp-3500	321	24	c.	c.	PROPN
fnp-3500	321	25	dittmayer1	dittmayer1	PROPN
fnp-3500	321	26	,	,	PUNCT
fnp-3500	321	27	h.	h.	PROPN
fnp-3500	321	28	h.	h.	PROPN
fnp-3500	321	29	goebel1,2	goebel1,2	PROPN
fnp-3500	321	30	,	,	PUNCT
fnp-3500	321	31	f.	f.	PROPN
fnp-3500	321	32	l.	l.	PROPN
fnp-3500	321	33	heppner1	heppner1	PROPN
fnp-3500	321	34	,	,	PUNCT
fnp-3500	321	35	w.	w.	PROPN
fnp-3500	321	36	stenzel1	stenzel1	PROPN
fnp-3500	321	37	1	1	NUM
fnp-3500	321	38	charité	charité	ADJ
fnp-3500	321	39	–	–	PUNCT
fnp-3500	321	40	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	321	41	berlin	berlin	PROPN
fnp-3500	321	42	,	,	PUNCT
fnp-3500	321	43	department	department	NOUN
fnp-3500	321	44	of	of	ADP
fnp-3500	321	45	neuropathology	neuropathology	NOUN
fnp-3500	321	46	,	,	PUNCT
fnp-3500	321	47	berlin	berlin	PROPN
fnp-3500	321	48	,	,	PUNCT
fnp-3500	321	49	germany	germany	PROPN
fnp-3500	321	50	2	2	NUM
fnp-3500	321	51	johannes	johannes	PROPN
fnp-3500	321	52	-	-	PUNCT
fnp-3500	321	53	guttenberg	guttenberg	PROPN
fnp-3500	321	54	universität	universität	PROPN
fnp-3500	321	55	,	,	PUNCT
fnp-3500	321	56	department	department	NOUN
fnp-3500	321	57	of	of	ADP
fnp-3500	321	58	neuropathology	neuropathology	NOUN
fnp-3500	321	59	,	,	PUNCT
fnp-3500	321	60	mainz	mainz	PROPN
fnp-3500	321	61	,	,	PUNCT
fnp-3500	321	62	germany	germany	PROPN
fnp-3500	321	63	introduction	introduction	NOUN
fnp-3500	321	64	:	:	PUNCT
fnp-3500	321	65	traditional	traditional	ADJ
fnp-3500	321	66	imaging	imaging	NOUN
fnp-3500	321	67	of	of	ADP
fnp-3500	321	68	sections	section	NOUN
fnp-3500	321	69	in	in	ADP
fnp-3500	321	70	diagnostic	diagnostic	ADJ
fnp-3500	321	71	or	or	CCONJ
fnp-3500	321	72	research	research	NOUN
fnp-3500	321	73	settings	setting	NOUN
fnp-3500	321	74	using	use	VERB
fnp-3500	321	75	transmission	transmission	NOUN
fnp-3500	321	76	electron	electron	NOUN
fnp-3500	321	77	microscopy	microscopy	NOUN
fnp-3500	321	78	(	(	PUNCT
fnp-3500	321	79	tem	tem	PROPN
fnp-3500	321	80	)	)	PUNCT
fnp-3500	321	81	is	be	AUX
fnp-3500	321	82	limited	limit	VERB
fnp-3500	321	83	by	by	ADP
fnp-3500	321	84	manual	manual	ADJ
fnp-3500	321	85	acquisition	acquisition	NOUN
fnp-3500	321	86	procedures	procedure	NOUN
fnp-3500	321	87	.	.	PUNCT
fnp-3500	322	1	thus	thus	ADV
fnp-3500	322	2	,	,	PUNCT
fnp-3500	322	3	analysis	analysis	NOUN
fnp-3500	322	4	of	of	ADP
fnp-3500	322	5	samples	sample	NOUN
fnp-3500	322	6	is	be	AUX
fnp-3500	322	7	restricted	restrict	VERB
fnp-3500	322	8	to	to	ADP
fnp-3500	322	9	images	image	NOUN
fnp-3500	322	10	of	of	ADP
fnp-3500	322	11	few	few	ADJ
fnp-3500	322	12	preselected	preselecte	VERB
fnp-3500	322	13	regions	region	NOUN
fnp-3500	322	14	that	that	PRON
fnp-3500	322	15	may	may	AUX
fnp-3500	322	16	be	be	AUX
fnp-3500	322	17	non	non	ADJ
fnp-3500	322	18	-	-	ADJ
fnp-3500	322	19	representative	representative	ADJ
fnp-3500	322	20	and	and	CCONJ
fnp-3500	322	21	lack	lack	NOUN
fnp-3500	322	22	correlation	correlation	NOUN
fnp-3500	322	23	to	to	ADP
fnp-3500	322	24	their	their	PRON
fnp-3500	322	25	microanatomical	microanatomical	ADJ
fnp-3500	322	26	context	context	NOUN
fnp-3500	322	27	.	.	PUNCT
fnp-3500	323	1	modern	modern	ADJ
fnp-3500	323	2	scanning	scanning	NOUN
fnp-3500	323	3	electron	electron	NOUN
fnp-3500	323	4	microscopes	microscope	NOUN
fnp-3500	323	5	allow	allow	VERB
fnp-3500	323	6	unbiased	unbiased	ADJ
fnp-3500	323	7	digitization	digitization	NOUN
fnp-3500	323	8	of	of	ADP
fnp-3500	323	9	entire	entire	ADJ
fnp-3500	323	10	large	large	ADJ
fnp-3500	323	11	sections	section	NOUN
fnp-3500	323	12	and	and	CCONJ
fnp-3500	323	13	improved	improve	VERB
fnp-3500	323	14	analysis	analysis	NOUN
fnp-3500	323	15	,	,	PUNCT
fnp-3500	323	16	but	but	CCONJ
fnp-3500	323	17	performance	performance	NOUN
fnp-3500	323	18	is	be	AUX
fnp-3500	323	19	limited	limit	VERB
fnp-3500	323	20	by	by	ADP
fnp-3500	323	21	preparation	preparation	NOUN
fnp-3500	323	22	artifacts	artifact	NOUN
fnp-3500	323	23	.	.	PUNCT
fnp-3500	324	1	objectives	objective	NOUN
fnp-3500	324	2	:	:	PUNCT
fnp-3500	324	3	we	we	PRON
fnp-3500	324	4	aimed	aim	VERB
fnp-3500	324	5	at	at	ADP
fnp-3500	324	6	an	an	DET
fnp-3500	324	7	improved	improved	ADJ
fnp-3500	324	8	preparation	preparation	NOUN
fnp-3500	324	9	of	of	ADP
fnp-3500	324	10	sections	section	NOUN
fnp-3500	324	11	for	for	ADP
fnp-3500	324	12	large	large	ADJ
fnp-3500	324	13	-	-	PUNCT
fnp-3500	324	14	scale	scale	NOUN
fnp-3500	324	15	electron	electron	NOUN
fnp-3500	324	16	microscopy	microscopy	NOUN
fnp-3500	324	17	(	(	PUNCT
fnp-3500	324	18	em	em	PRON
fnp-3500	324	19	)	)	PUNCT
fnp-3500	324	20	and	and	CCONJ
fnp-3500	324	21	at	at	ADP
fnp-3500	324	22	a	a	DET
fnp-3500	324	23	pipeline	pipeline	NOUN
fnp-3500	324	24	for	for	ADP
fnp-3500	324	25	data	data	NOUN
fnp-3500	324	26	processing	processing	NOUN
fnp-3500	324	27	and	and	CCONJ
fnp-3500	324	28	analysis	analysis	NOUN
fnp-3500	324	29	.	.	PUNCT
fnp-3500	325	1	material	material	NOUN
fnp-3500	325	2	&	&	CCONJ
fnp-3500	325	3	methods	method	NOUN
fnp-3500	325	4	:	:	PUNCT
fnp-3500	325	5	we	we	PRON
fnp-3500	325	6	achieved	achieve	VERB
fnp-3500	325	7	wrinkle	wrinkle	NOUN
fnp-3500	325	8	-	-	PUNCT
fnp-3500	325	9	free	free	ADJ
fnp-3500	325	10	collection	collection	NOUN
fnp-3500	325	11	of	of	ADP
fnp-3500	325	12	sections	section	NOUN
fnp-3500	325	13	by	by	ADP
fnp-3500	325	14	a	a	DET
fnp-3500	325	15	combined	combine	VERB
fnp-3500	325	16	glow	glow	NOUN
fnp-3500	325	17	-	-	PUNCT
fnp-3500	325	18	discharge	discharge	NOUN
fnp-3500	325	19	and	and	CCONJ
fnp-3500	325	20	ethanol	ethanol	NOUN
fnp-3500	325	21	-	-	PUNCT
fnp-3500	325	22	based	base	VERB
fnp-3500	325	23	smoothening	smoothen	VERB
fnp-3500	325	24	procedure	procedure	NOUN
fnp-3500	325	25	and	and	CCONJ
fnp-3500	325	26	reduced	reduce	VERB
fnp-3500	325	27	filming	filming	NOUN
fnp-3500	325	28	and	and	CCONJ
fnp-3500	325	29	staining	stain	VERB
fnp-3500	325	30	artifacts	artifact	NOUN
fnp-3500	325	31	.	.	PUNCT
fnp-3500	326	1	a	a	DET
fnp-3500	326	2	scanning	scan	VERB
fnp-3500	326	3	electron	electron	NOUN
fnp-3500	326	4	microscope	microscope	NOUN
fnp-3500	326	5	with	with	ADP
fnp-3500	326	6	a	a	DET
fnp-3500	326	7	scanning	scan	VERB
fnp-3500	326	8	transmission	transmission	NOUN
fnp-3500	326	9	electron	electron	NOUN
fnp-3500	326	10	microscopy	microscopy	NOUN
fnp-3500	326	11	detector	detector	NOUN
fnp-3500	326	12	was	be	AUX
fnp-3500	326	13	used	use	VERB
fnp-3500	326	14	for	for	ADP
fnp-3500	326	15	pre	pre	ADJ
fnp-3500	326	16	-	-	NOUN
fnp-3500	326	17	irradiation	irradiation	NOUN
fnp-3500	326	18	and	and	CCONJ
fnp-3500	326	19	imaging	imaging	NOUN
fnp-3500	326	20	.	.	PUNCT
fnp-3500	327	1	imaging	imaging	NOUN
fnp-3500	327	2	parameters	parameter	NOUN
fnp-3500	327	3	were	be	AUX
fnp-3500	327	4	varied	varied	ADJ
fnp-3500	327	5	to	to	PART
fnp-3500	327	6	achieve	achieve	VERB
fnp-3500	327	7	fast	fast	ADJ
fnp-3500	327	8	imaging	imaging	NOUN
fnp-3500	327	9	and	and	CCONJ
fnp-3500	327	10	adequate	adequate	ADJ
fnp-3500	327	11	image	image	NOUN
fnp-3500	327	12	quality	quality	NOUN
fnp-3500	327	13	.	.	PUNCT
fnp-3500	328	1	we	we	PRON
fnp-3500	328	2	used	use	VERB
fnp-3500	328	3	trakem2	trakem2	NOUN
fnp-3500	328	4	and	and	CCONJ
fnp-3500	328	5	nip2	nip2	VERB
fnp-3500	328	6	for	for	ADP
fnp-3500	328	7	stitching	stitching	NOUN
fnp-3500	328	8	of	of	ADP
fnp-3500	328	9	image	image	NOUN
fnp-3500	328	10	tiles	tile	NOUN
fnp-3500	328	11	to	to	PART
fnp-3500	328	12	generate	generate	VERB
fnp-3500	328	13	coherent	coherent	ADJ
fnp-3500	328	14	bigtif	bigtif	NOUN
fnp-3500	328	15	datasets	dataset	NOUN
fnp-3500	328	16	,	,	PUNCT
fnp-3500	328	17	thus	thus	ADV
fnp-3500	328	18	allowing	allow	VERB
fnp-3500	328	19	in	in	ADP
fnp-3500	328	20	-	-	PUNCT
fnp-3500	328	21	depth	depth	NOUN
fnp-3500	328	22	analysis	analysis	NOUN
fnp-3500	328	23	via	via	ADP
fnp-3500	328	24	qupath	qupath	NOUN
fnp-3500	328	25	.	.	PUNCT
fnp-3500	329	1	results	result	NOUN
fnp-3500	329	2	:	:	PUNCT
fnp-3500	329	3	our	our	PRON
fnp-3500	329	4	preparation	preparation	NOUN
fnp-3500	329	5	workflow	workflow	NOUN
fnp-3500	329	6	allowed	allow	VERB
fnp-3500	329	7	to	to	PART
fnp-3500	329	8	reliably	reliably	ADV
fnp-3500	329	9	prepare	prepare	VERB
fnp-3500	329	10	samples	sample	NOUN
fnp-3500	329	11	with	with	ADP
fnp-3500	329	12	virtual	virtual	ADJ
fnp-3500	329	13	absence	absence	NOUN
fnp-3500	329	14	of	of	ADP
fnp-3500	329	15	limiting	limit	VERB
fnp-3500	329	16	artifacts	artifact	NOUN
fnp-3500	329	17	,	,	PUNCT
fnp-3500	329	18	such	such	ADJ
fnp-3500	329	19	wrinkles	wrinkle	NOUN
fnp-3500	329	20	and	and	CCONJ
fnp-3500	329	21	stain	stain	NOUN
fnp-3500	329	22	precipitates	precipitate	NOUN
fnp-3500	329	23	.	.	PUNCT
fnp-3500	330	1	up	up	ADP
fnp-3500	330	2	to	to	PART
fnp-3500	330	3	12	12	NUM
fnp-3500	330	4	entire	entire	ADJ
fnp-3500	330	5	sections	section	NOUN
fnp-3500	330	6	were	be	AUX
fnp-3500	330	7	automatically	automatically	ADV
fnp-3500	330	8	digitized	digitize	VERB
fnp-3500	330	9	in	in	ADP
fnp-3500	330	10	about	about	ADV
fnp-3500	330	11	6	6	NUM
fnp-3500	330	12	days	day	NOUN
fnp-3500	330	13	using	use	VERB
fnp-3500	330	14	7.3	7.3	NUM
fnp-3500	330	15	nm	nm	ADJ
fnp-3500	330	16	pixel	pixel	NOUN
fnp-3500	330	17	size	size	NOUN
fnp-3500	330	18	and	and	CCONJ
fnp-3500	330	19	1.0	1.0	NUM
fnp-3500	330	20	µs	µs	NOUN
fnp-3500	330	21	dwell	dwell	NOUN
fnp-3500	330	22	time	time	NOUN
fnp-3500	330	23	.	.	PUNCT
fnp-3500	331	1	our	our	PRON
fnp-3500	331	2	data	data	NOUN
fnp-3500	331	3	processing	processing	NOUN
fnp-3500	331	4	pipeline	pipeline	NOUN
fnp-3500	331	5	allowed	allow	VERB
fnp-3500	331	6	batch	batch	NOUN
fnp-3500	331	7	generation	generation	NOUN
fnp-3500	331	8	of	of	ADP
fnp-3500	331	9	bigtif	bigtif	ADJ
fnp-3500	331	10	files	file	NOUN
fnp-3500	331	11	with	with	ADP
fnp-3500	331	12	minimal	minimal	ADJ
fnp-3500	331	13	operator	operator	NOUN
fnp-3500	331	14	involvement	involvement	NOUN
fnp-3500	331	15	.	.	PUNCT
fnp-3500	332	1	conclusion	conclusion	NOUN
fnp-3500	332	2	:	:	PUNCT
fnp-3500	332	3	we	we	PRON
fnp-3500	332	4	propose	propose	VERB
fnp-3500	332	5	a	a	DET
fnp-3500	332	6	highly	highly	ADV
fnp-3500	332	7	reliable	reliable	ADJ
fnp-3500	332	8	workflow	workflow	NOUN
fnp-3500	332	9	for	for	ADP
fnp-3500	332	10	preparation	preparation	NOUN
fnp-3500	332	11	,	,	PUNCT
fnp-3500	332	12	imaging	imaging	NOUN
fnp-3500	332	13	and	and	CCONJ
fnp-3500	332	14	data	datum	NOUN
fnp-3500	332	15	processing	processing	NOUN
fnp-3500	332	16	of	of	ADP
fnp-3500	332	17	samples	sample	NOUN
fnp-3500	332	18	with	with	ADP
fnp-3500	332	19	superior	superior	ADJ
fnp-3500	332	20	quality	quality	NOUN
fnp-3500	332	21	to	to	PART
fnp-3500	332	22	enable	enable	VERB
fnp-3500	332	23	routine	routine	ADJ
fnp-3500	332	24	large	large	ADJ
fnp-3500	332	25	-	-	PUNCT
fnp-3500	332	26	scale	scale	NOUN
fnp-3500	332	27	em	em	PRON
fnp-3500	332	28	in	in	ADP
fnp-3500	332	29	diagnostic	diagnostic	ADJ
fnp-3500	332	30	and	and	CCONJ
fnp-3500	332	31	research	research	NOUN
fnp-3500	332	32	settings	setting	NOUN
fnp-3500	332	33	.	.	PUNCT
fnp-3500	333	1	we	we	PRON
fnp-3500	333	2	demonstrate	demonstrate	VERB
fnp-3500	333	3	the	the	DET
fnp-3500	333	4	high	high	ADJ
fnp-3500	333	5	pragmatic	pragmatic	ADJ
fnp-3500	333	6	value	value	NOUN
fnp-3500	333	7	of	of	ADP
fnp-3500	333	8	our	our	PRON
fnp-3500	333	9	workflow	workflow	NOUN
fnp-3500	333	10	with	with	ADP
fnp-3500	333	11	data	datum	NOUN
fnp-3500	333	12	of	of	ADP
fnp-3500	333	13	different	different	ADJ
fnp-3500	333	14	published	publish	VERB
fnp-3500	333	15	and	and	CCONJ
fnp-3500	333	16	unpublished	unpublished	ADJ
fnp-3500	333	17	projects	project	NOUN
fnp-3500	333	18	in	in	ADP
fnp-3500	333	19	the	the	DET
fnp-3500	333	20	field	field	NOUN
fnp-3500	333	21	of	of	ADP
fnp-3500	333	22	muscle	muscle	NOUN
fnp-3500	333	23	pathology	pathology	NOUN
fnp-3500	333	24	and	and	CCONJ
fnp-3500	333	25	ultrastructural	ultrastructural	ADJ
fnp-3500	333	26	characterization	characterization	NOUN
fnp-3500	333	27	of	of	ADP
fnp-3500	333	28	sars	sar	NOUN
fnp-3500	333	29	-	-	PUNCT
fnp-3500	333	30	cov-2	cov-2	NOUN
fnp-3500	333	31	in	in	ADP
fnp-3500	333	32	autopsy	autopsy	ADJ
fnp-3500	333	33	tissues	tissue	NOUN
fnp-3500	333	34	.	.	PUNCT
fnp-3500	333	35	  	  	SPACE
fnp-3500	334	1	piii-02	piii-02	ADJ
fnp-3500	334	2	free	free	ADJ
fnp-3500	334	3	neuropathol	neuropathol	NOUN
fnp-3500	334	4	2:22:38	2:22:38	NUM
fnp-3500	334	5	nanostring	nanostre	VERB
fnp-3500	334	6	technology	technology	NOUN
fnp-3500	334	7	distinguishes	distinguish	VERB
fnp-3500	334	8	anti	anti	ADJ
fnp-3500	334	9	-	-	NOUN
fnp-3500	334	10	tif-1γ+	tif-1γ+	ADJ
fnp-3500	334	11	from	from	ADP
fnp-3500	334	12	anti	anti	ADJ
fnp-3500	334	13	-	-	NOUN
fnp-3500	334	14	mi-2	mi-2	ADJ
fnp-3500	334	15	+	+	NOUN
fnp-3500	334	16	dermatomyositis	dermatomyositis	NOUN
fnp-3500	334	17	patients	patient	NOUN
fnp-3500	334	18	c.	c.	PROPN
fnp-3500	334	19	preuße1,2	preuße1,2	PROPN
fnp-3500	334	20	,	,	PUNCT
fnp-3500	334	21	p.	p.	PROPN
fnp-3500	334	22	eede1	eede1	PROPN
fnp-3500	334	23	,	,	PUNCT
fnp-3500	334	24	l.	l.	PROPN
fnp-3500	334	25	heinzeling3,4	heinzeling3,4	PROPN
fnp-3500	334	26	,	,	PUNCT
fnp-3500	334	27	k.	k.	PROPN
fnp-3500	334	28	freitag1,5	freitag1,5	PROPN
fnp-3500	334	29	,	,	PUNCT
fnp-3500	334	30	r.	r.	PROPN
fnp-3500	334	31	koll1,6	koll1,6	PROPN
fnp-3500	334	32	,	,	PUNCT
fnp-3500	334	33	w.	w.	PROPN
fnp-3500	334	34	froehlich3	froehlich3	PROPN
fnp-3500	334	35	,	,	PUNCT
fnp-3500	334	36	u.	u.	PROPN
fnp-3500	334	37	schneider7	schneider7	PROPN
fnp-3500	334	38	,	,	PUNCT
fnp-3500	334	39	y.	y.	PROPN
fnp-3500	334	40	allenbach8	allenbach8	PROPN
fnp-3500	334	41	,	,	PUNCT
fnp-3500	334	42	o.	o.	PROPN
fnp-3500	334	43	benveniste8	benveniste8	PROPN
fnp-3500	334	44	,	,	PUNCT
fnp-3500	334	45	a.	a.	NOUN
fnp-3500	334	46	schänzer9	schänzer9	PROPN
fnp-3500	334	47	,	,	PUNCT
fnp-3500	334	48	h.	h.	PROPN
fnp-3500	334	49	h.	h.	PROPN
fnp-3500	334	50	goebel1	goebel1	PROPN
fnp-3500	334	51	,	,	PUNCT
fnp-3500	334	52	w.	w.	PROPN
fnp-3500	334	53	stenzel1	stenzel1	PROPN
fnp-3500	334	54	,	,	PUNCT
fnp-3500	334	55	j.	j.	PROPN
fnp-3500	334	56	radke1,6	radke1,6	PROPN
fnp-3500	334	57	1	1	NUM
fnp-3500	334	58	charité	charité	PROPN
fnp-3500	334	59	–	–	PUNCT
fnp-3500	334	60	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	334	61	berlin	berlin	PROPN
fnp-3500	334	62	,	,	PUNCT
fnp-3500	334	63	neuropathology	neuropathology	NOUN
fnp-3500	334	64	,	,	PUNCT
fnp-3500	334	65	berlin	berlin	PROPN
fnp-3500	334	66	,	,	PUNCT
fnp-3500	334	67	germany	germany	PROPN
fnp-3500	334	68	2	2	NUM
fnp-3500	334	69	münster	münster	NOUN
fnp-3500	334	70	university	university	NOUN
fnp-3500	334	71	hospital	hospital	NOUN
fnp-3500	334	72	,	,	PUNCT
fnp-3500	334	73	neurology	neurology	NOUN
fnp-3500	334	74	with	with	ADP
fnp-3500	334	75	institute	institute	PROPN
fnp-3500	334	76	for	for	ADP
fnp-3500	334	77	translational	translational	ADJ
fnp-3500	334	78	neurology	neurology	NOUN
fnp-3500	334	79	,	,	PUNCT
fnp-3500	334	80	münster	münster	NOUN
fnp-3500	334	81	,	,	PUNCT
fnp-3500	334	82	germany	germany	PROPN
fnp-3500	334	83	3	3	NUM
fnp-3500	334	84	university	university	NOUN
fnp-3500	334	85	hospital	hospital	NOUN
fnp-3500	334	86	of	of	ADP
fnp-3500	334	87	erlangen	erlangen	PROPN
fnp-3500	334	88	,	,	PUNCT
fnp-3500	334	89	dermatology	dermatology	NOUN
fnp-3500	334	90	,	,	PUNCT
fnp-3500	334	91	erlangen	erlangen	PROPN
fnp-3500	334	92	,	,	PUNCT
fnp-3500	334	93	germany	germany	PROPN
fnp-3500	334	94	4	4	NUM
fnp-3500	334	95	lmu	lmu	NOUN
fnp-3500	334	96	klinikum	klinikum	NOUN
fnp-3500	334	97	,	,	PUNCT
fnp-3500	334	98	dermatology	dermatology	NOUN
fnp-3500	334	99	,	,	PUNCT
fnp-3500	334	100	münchen	münchen	NOUN
fnp-3500	334	101	,	,	PUNCT
fnp-3500	334	102	germany	germany	PROPN
fnp-3500	334	103	5	5	NUM
fnp-3500	334	104	german	german	ADJ
fnp-3500	334	105	center	center	NOUN
fnp-3500	334	106	for	for	ADP
fnp-3500	334	107	neurodegenerative	neurodegenerative	ADJ
fnp-3500	334	108	diseases	disease	NOUN
fnp-3500	334	109	(	(	PUNCT
fnp-3500	334	110	dzne	dzne	NOUN
fnp-3500	334	111	)	)	PUNCT
fnp-3500	334	112	within	within	ADP
fnp-3500	334	113	the	the	DET
fnp-3500	334	114	helmholtz	helmholtz	PROPN
fnp-3500	334	115	association	association	PROPN
fnp-3500	334	116	,	,	PUNCT
fnp-3500	334	117	berlin	berlin	PROPN
fnp-3500	334	118	,	,	PUNCT
fnp-3500	334	119	germany	germany	PROPN
fnp-3500	334	120	6	6	NUM
fnp-3500	334	121	german	german	ADJ
fnp-3500	334	122	cancer	cancer	NOUN
fnp-3500	334	123	consortium	consortium	NOUN
fnp-3500	334	124	(	(	PUNCT
fnp-3500	334	125	dktk	dktk	NOUN
fnp-3500	334	126	)	)	PUNCT
fnp-3500	334	127	,	,	PUNCT
fnp-3500	334	128	german	german	ADJ
fnp-3500	334	129	cancer	cancer	NOUN
fnp-3500	334	130	research	research	NOUN
fnp-3500	334	131	center	center	NOUN
fnp-3500	334	132	(	(	PUNCT
fnp-3500	334	133	dkfz	dkfz	PROPN
fnp-3500	334	134	)	)	PUNCT
fnp-3500	334	135	,	,	PUNCT
fnp-3500	334	136	berlin	berlin	PROPN
fnp-3500	334	137	,	,	PUNCT
fnp-3500	334	138	germany	germany	PROPN
fnp-3500	334	139	7	7	NUM
fnp-3500	334	140	charité	charité	PROPN
fnp-3500	334	141	–	–	PUNCT
fnp-3500	334	142	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	334	143	berlin	berlin	PROPN
fnp-3500	334	144	,	,	PUNCT
fnp-3500	334	145	rheumatology	rheumatology	NOUN
fnp-3500	334	146	,	,	PUNCT
fnp-3500	334	147	berlin	berlin	PROPN
fnp-3500	334	148	,	,	PUNCT
fnp-3500	334	149	germany	germany	PROPN
fnp-3500	334	150	8	8	NUM
fnp-3500	334	151	pitié	pitié	PROPN
fnp-3500	334	152	-	-	PUNCT
fnp-3500	334	153	salpêtrière	salpêtrière	PROPN
fnp-3500	334	154	university	university	NOUN
fnp-3500	334	155	hospital	hospital	NOUN
fnp-3500	334	156	,	,	PUNCT
fnp-3500	334	157	internal	internal	ADJ
fnp-3500	334	158	medicine	medicine	NOUN
fnp-3500	334	159	and	and	CCONJ
fnp-3500	334	160	clinical	clinical	ADJ
fnp-3500	334	161	immunology	immunology	NOUN
fnp-3500	334	162	,	,	PUNCT
fnp-3500	334	163	paris	paris	PROPN
fnp-3500	334	164	,	,	PUNCT
fnp-3500	334	165	france	france	PROPN
fnp-3500	334	166	9	9	NUM
fnp-3500	334	167	justus	justus	PROPN
fnp-3500	334	168	-	-	PUNCT
fnp-3500	334	169	liebig	liebig	NOUN
fnp-3500	334	170	-	-	PUNCT
fnp-3500	334	171	university	university	NOUN
fnp-3500	334	172	gießen	gießen	NOUN
fnp-3500	334	173	,	,	PUNCT
fnp-3500	334	174	neuropathology	neuropathology	NOUN
fnp-3500	334	175	,	,	PUNCT
fnp-3500	334	176	gießen	gießen	PROPN
fnp-3500	334	177	,	,	PUNCT
fnp-3500	334	178	germany	germany	PROPN
fnp-3500	334	179	introduction	introduction	NOUN
fnp-3500	334	180	:	:	PUNCT
fnp-3500	334	181	dermatomyositis	dermatomyositis	PROPN
fnp-3500	334	182	(	(	PUNCT
fnp-3500	334	183	dm	dm	PROPN
fnp-3500	334	184	)	)	PUNCT
fnp-3500	334	185	is	be	AUX
fnp-3500	334	186	a	a	DET
fnp-3500	334	187	systemic	systemic	ADJ
fnp-3500	334	188	idiopathic	idiopathic	ADJ
fnp-3500	334	189	inflammatory	inflammatory	ADJ
fnp-3500	334	190	disease	disease	NOUN
fnp-3500	334	191	affecting	affect	VERB
fnp-3500	334	192	skeletal	skeletal	ADJ
fnp-3500	334	193	muscle	muscle	NOUN
fnp-3500	334	194	and	and	CCONJ
fnp-3500	334	195	skin	skin	NOUN
fnp-3500	334	196	,	,	PUNCT
fnp-3500	334	197	clinically	clinically	ADV
fnp-3500	334	198	characterized	characterize	VERB
fnp-3500	334	199	by	by	ADP
fnp-3500	334	200	symmetrical	symmetrical	ADJ
fnp-3500	334	201	proximal	proximal	ADJ
fnp-3500	334	202	muscle	muscle	NOUN
fnp-3500	334	203	weakness	weakness	NOUN
fnp-3500	334	204	and	and	CCONJ
fnp-3500	334	205	typical	typical	ADJ
fnp-3500	334	206	skin	skin	NOUN
fnp-3500	334	207	lesions	lesion	NOUN
fnp-3500	334	208	.	.	PUNCT
fnp-3500	335	1	recently	recently	ADV
fnp-3500	335	2	,	,	PUNCT
fnp-3500	335	3	myositis	myositis	NOUN
fnp-3500	335	4	-	-	PUNCT
fnp-3500	335	5	specific	specific	ADJ
fnp-3500	335	6	autoantibodies	autoantibody	NOUN
fnp-3500	335	7	(	(	PUNCT
fnp-3500	335	8	msa	msa	PROPN
fnp-3500	335	9	)	)	PUNCT
fnp-3500	335	10	became	become	VERB
fnp-3500	335	11	of	of	ADP
fnp-3500	335	12	utmost	utmost	ADJ
fnp-3500	335	13	importance	importance	NOUN
fnp-3500	335	14	because	because	SCONJ
fnp-3500	335	15	they	they	PRON
fnp-3500	335	16	strongly	strongly	ADV
fnp-3500	335	17	correlate	correlate	VERB
fnp-3500	335	18	with	with	ADP
fnp-3500	335	19	distinct	distinct	ADJ
fnp-3500	335	20	clinical	clinical	ADJ
fnp-3500	335	21	manifestations	manifestation	NOUN
fnp-3500	335	22	and	and	CCONJ
fnp-3500	335	23	prognosis	prognosis	NOUN
fnp-3500	335	24	.	.	PUNCT
fnp-3500	336	1	antibodies	antibodie	VERB
fnp-3500	336	2	against	against	ADP
fnp-3500	336	3	transcription	transcription	NOUN
fnp-3500	336	4	intermediary	intermediary	ADJ
fnp-3500	336	5	factor	factor	NOUN
fnp-3500	336	6	1γ	1γ	NUM
fnp-3500	336	7	(	(	PUNCT
fnp-3500	336	8	tif-1γ	tif-1γ	PROPN
fnp-3500	336	9	)	)	PUNCT
fnp-3500	336	10	are	be	AUX
fnp-3500	336	11	frequently	frequently	ADV
fnp-3500	336	12	associated	associate	VERB
fnp-3500	336	13	with	with	ADP
fnp-3500	336	14	increased	increase	VERB
fnp-3500	336	15	risk	risk	NOUN
fnp-3500	336	16	of	of	ADP
fnp-3500	336	17	malignancy	malignancy	NOUN
fnp-3500	336	18	,	,	PUNCT
fnp-3500	336	19	a	a	DET
fnp-3500	336	20	specific	specific	ADJ
fnp-3500	336	21	cutaneous	cutaneous	ADJ
fnp-3500	336	22	phenotype	phenotype	NOUN
fnp-3500	336	23	and	and	CCONJ
fnp-3500	336	24	limited	limited	ADJ
fnp-3500	336	25	response	response	NOUN
fnp-3500	336	26	to	to	ADP
fnp-3500	336	27	therapy	therapy	NOUN
fnp-3500	336	28	in	in	ADP
fnp-3500	336	29	adult	adult	NOUN
fnp-3500	336	30	dm	dm	NOUN
fnp-3500	336	31	patients	patient	NOUN
fnp-3500	336	32	.	.	PUNCT
fnp-3500	337	1	anti	anti	ADJ
fnp-3500	337	2	-	-	ADJ
fnp-3500	337	3	mi-2	mi-2	ADJ
fnp-3500	337	4	autoantibodies	autoantibody	NOUN
fnp-3500	337	5	,	,	PUNCT
fnp-3500	337	6	in	in	ADP
fnp-3500	337	7	contrast	contrast	NOUN
fnp-3500	337	8	,	,	PUNCT
fnp-3500	337	9	are	be	AUX
fnp-3500	337	10	typically	typically	ADV
fnp-3500	337	11	associated	associate	VERB
fnp-3500	337	12	with	with	ADP
fnp-3500	337	13	classic	classic	ADJ
fnp-3500	337	14	dm	dm	PROPN
fnp-3500	337	15	rashes	rash	NOUN
fnp-3500	337	16	,	,	PUNCT
fnp-3500	337	17	prominent	prominent	ADJ
fnp-3500	337	18	skeletal	skeletal	ADJ
fnp-3500	337	19	muscle	muscle	NOUN
fnp-3500	337	20	weakness	weakness	NOUN
fnp-3500	337	21	,	,	PUNCT
fnp-3500	337	22	better	well	ADJ
fnp-3500	337	23	therapeutic	therapeutic	ADJ
fnp-3500	337	24	response	response	NOUN
fnp-3500	337	25	and	and	CCONJ
fnp-3500	337	26	prognosis	prognosis	NOUN
fnp-3500	337	27	,	,	PUNCT
fnp-3500	337	28	and	and	CCONJ
fnp-3500	337	29	less	less	ADV
fnp-3500	337	30	frequently	frequently	ADV
fnp-3500	337	31	with	with	ADP
fnp-3500	337	32	cancer	cancer	NOUN
fnp-3500	337	33	.	.	PUNCT
fnp-3500	338	1	the	the	DET
fnp-3500	338	2	correlation	correlation	NOUN
fnp-3500	338	3	of	of	ADP
fnp-3500	338	4	cancer	cancer	NOUN
fnp-3500	338	5	and	and	CCONJ
fnp-3500	338	6	mi-2	mi-2	NOUN
fnp-3500	338	7	autoantibodies	autoantibody	NOUN
fnp-3500	338	8	,	,	PUNCT
fnp-3500	338	9	however	however	ADV
fnp-3500	338	10	,	,	PUNCT
fnp-3500	338	11	remains	remain	VERB
fnp-3500	338	12	debated	debate	VERB
fnp-3500	338	13	.	.	PUNCT
fnp-3500	339	1	objectives	objective	NOUN
fnp-3500	339	2	:	:	PUNCT
fnp-3500	339	3	to	to	PART
fnp-3500	339	4	further	far	ADV
fnp-3500	339	5	investigate	investigate	VERB
fnp-3500	339	6	the	the	DET
fnp-3500	339	7	both	both	PRON
fnp-3500	339	8	clinically	clinically	ADV
fnp-3500	339	9	distinct	distinct	ADJ
fnp-3500	339	10	dm	dm	NOUN
fnp-3500	339	11	subgroups	subgroup	NOUN
fnp-3500	339	12	and	and	CCONJ
fnp-3500	339	13	visualize	visualize	VERB
fnp-3500	339	14	differences	difference	NOUN
fnp-3500	339	15	or	or	CCONJ
fnp-3500	339	16	similarities	similarity	NOUN
fnp-3500	339	17	on	on	ADP
fnp-3500	339	18	gene	gene	NOUN
fnp-3500	339	19	and	and	CCONJ
fnp-3500	339	20	protein	protein	NOUN
fnp-3500	339	21	level	level	NOUN
fnp-3500	339	22	.	.	PUNCT
fnp-3500	340	1	patients	patient	NOUN
fnp-3500	340	2	&	&	CCONJ
fnp-3500	340	3	methods	method	NOUN
fnp-3500	340	4	:	:	PUNCT
fnp-3500	340	5	we	we	PRON
fnp-3500	340	6	analyzed	analyze	VERB
fnp-3500	340	7	30	30	NUM
fnp-3500	340	8	dm	dm	PROPN
fnp-3500	340	9	patients	patient	NOUN
fnp-3500	340	10	(	(	PUNCT
fnp-3500	340	11	n=15	n=15	ADV
fnp-3500	340	12	mi2	mi2	PROPN
fnp-3500	340	13	+	+	PROPN
fnp-3500	340	14	and	and	CCONJ
fnp-3500	340	15	n=15	n=15	ADV
fnp-3500	340	16	tif-1γ+	tif-1γ+	ADJ
fnp-3500	340	17	)	)	PUNCT
fnp-3500	340	18	and	and	CCONJ
fnp-3500	340	19	8	8	NUM
fnp-3500	340	20	non	non	ADJ
fnp-3500	340	21	-	-	ADJ
fnp-3500	340	22	disease	disease	ADJ
fnp-3500	340	23	controls	control	NOUN
fnp-3500	340	24	(	(	PUNCT
fnp-3500	340	25	ndc	ndc	NOUN
fnp-3500	340	26	)	)	PUNCT
fnp-3500	340	27	by	by	ADP
fnp-3500	340	28	nanostring	nanostre	VERB
fnp-3500	340	29	,	,	PUNCT
fnp-3500	340	30	qpcr	qpcr	ADJ
fnp-3500	340	31	,	,	PUNCT
fnp-3500	340	32	and	and	CCONJ
fnp-3500	340	33	immunohistochmistry	immunohistochmistry	NOUN
fnp-3500	340	34	.	.	PUNCT
fnp-3500	341	1	results	result	NOUN
fnp-3500	341	2	:	:	PUNCT
fnp-3500	341	3	both	both	DET
fnp-3500	341	4	anti	anti	ADJ
fnp-3500	341	5	-	-	ADJ
fnp-3500	341	6	tif-1γ+	tif-1γ+	ADJ
fnp-3500	341	7	and	and	CCONJ
fnp-3500	341	8	anti	anti	ADJ
fnp-3500	341	9	-	-	NOUN
fnp-3500	341	10	mi-2	mi-2	ADJ
fnp-3500	341	11	+	+	CCONJ
fnp-3500	341	12	patients	patient	NOUN
fnp-3500	341	13	"	"	PUNCT
fnp-3500	341	14	skeletal	skeletal	ADJ
fnp-3500	341	15	muscle	muscle	NOUN
fnp-3500	341	16	biopsies	biopsy	NOUN
fnp-3500	341	17	revealed	reveal	VERB
fnp-3500	341	18	strong	strong	ADJ
fnp-3500	341	19	dysregulation	dysregulation	NOUN
fnp-3500	341	20	of	of	ADP
fnp-3500	341	21	immune	immune	ADJ
fnp-3500	341	22	response	response	NOUN
fnp-3500	341	23	-	-	PUNCT
fnp-3500	341	24	related	relate	VERB
fnp-3500	341	25	genes	gene	NOUN
fnp-3500	341	26	compared	compare	VERB
fnp-3500	341	27	to	to	ADP
fnp-3500	341	28	ndcs	ndc	NOUN
fnp-3500	341	29	.	.	PUNCT
fnp-3500	342	1	in	in	ADP
fnp-3500	342	2	line	line	NOUN
fnp-3500	342	3	with	with	ADP
fnp-3500	342	4	previous	previous	ADJ
fnp-3500	342	5	reports	report	NOUN
fnp-3500	342	6	,	,	PUNCT
fnp-3500	342	7	these	these	PRON
fnp-3500	342	8	included	include	VERB
fnp-3500	342	9	well	well	ADV
fnp-3500	342	10	-	-	PUNCT
fnp-3500	342	11	known	know	VERB
fnp-3500	342	12	type	type	NOUN
fnp-3500	342	13	1	1	NUM
fnp-3500	342	14	ifn	ifn	NOUN
fnp-3500	342	15	-	-	PUNCT
fnp-3500	342	16	inducible	inducible	ADJ
fnp-3500	342	17	genes	gene	NOUN
fnp-3500	342	18	;	;	PUNCT
fnp-3500	342	19	however	however	ADV
fnp-3500	342	20	,	,	PUNCT
fnp-3500	342	21	we	we	PRON
fnp-3500	342	22	also	also	ADV
fnp-3500	342	23	identified	identify	VERB
fnp-3500	342	24	subgroup	subgroup	NOUN
fnp-3500	342	25	-	-	PUNCT
fnp-3500	342	26	specific	specific	ADJ
fnp-3500	342	27	differences	difference	NOUN
fnp-3500	342	28	.	.	PUNCT
fnp-3500	343	1	conclusion	conclusion	NOUN
fnp-3500	343	2	:	:	PUNCT
fnp-3500	343	3	our	our	PRON
fnp-3500	343	4	results	result	NOUN
fnp-3500	343	5	help	help	VERB
fnp-3500	343	6	to	to	PART
fnp-3500	343	7	stratify	stratify	VERB
fnp-3500	343	8	both	both	DET
fnp-3500	343	9	subgroups	subgroup	NOUN
fnp-3500	343	10	and	and	CCONJ
fnp-3500	343	11	predict	predict	VERB
fnp-3500	343	12	,	,	PUNCT
fnp-3500	343	13	which	which	PRON
fnp-3500	343	14	dm	dm	NUM
fnp-3500	343	15	patients	patient	NOUN
fnp-3500	343	16	require	require	VERB
fnp-3500	343	17	an	an	DET
fnp-3500	343	18	intensified	intensified	ADJ
fnp-3500	343	19	diagnostic	diagnostic	ADJ
fnp-3500	343	20	procedure	procedure	NOUN
fnp-3500	343	21	and	and	CCONJ
fnp-3500	343	22	might	might	AUX
fnp-3500	343	23	have	have	VERB
fnp-3500	343	24	a	a	DET
fnp-3500	343	25	poorer	poor	ADJ
fnp-3500	343	26	outcome	outcome	NOUN
fnp-3500	343	27	.	.	PUNCT
fnp-3500	344	1	additionally	additionally	ADV
fnp-3500	344	2	,	,	PUNCT
fnp-3500	344	3	we	we	PRON
fnp-3500	344	4	demonstrate	demonstrate	VERB
fnp-3500	344	5	that	that	SCONJ
fnp-3500	344	6	the	the	DET
fnp-3500	344	7	nanostring	nanostre	VERB
fnp-3500	344	8	technology	technology	NOUN
fnp-3500	344	9	can	can	AUX
fnp-3500	344	10	be	be	AUX
fnp-3500	344	11	used	use	VERB
fnp-3500	344	12	as	as	ADP
fnp-3500	344	13	a	a	DET
fnp-3500	344	14	very	very	ADV
fnp-3500	344	15	sensitive	sensitive	ADJ
fnp-3500	344	16	method	method	NOUN
fnp-3500	344	17	to	to	PART
fnp-3500	344	18	clearly	clearly	ADV
fnp-3500	344	19	differentiate	differentiate	VERB
fnp-3500	344	20	two	two	NUM
fnp-3500	344	21	clinically	clinically	ADV
fnp-3500	344	22	distinct	distinct	ADJ
fnp-3500	344	23	dm	dm	PROPN
fnp-3500	344	24	subgroups	subgroup	NOUN
fnp-3500	344	25	,	,	PUNCT
fnp-3500	344	26	namely	namely	ADV
fnp-3500	344	27	mi2	mi2	PROPN
fnp-3500	344	28	+	+	PROPN
fnp-3500	344	29	and	and	CCONJ
fnp-3500	344	30	tif-1γ+	tif-1γ+	PROPN
fnp-3500	344	31	dermatomyositis	dermatomyositis	PROPN
fnp-3500	344	32	.	.	PUNCT
fnp-3500	345	1	potentially	potentially	ADV
fnp-3500	345	2	,	,	PUNCT
fnp-3500	345	3	this	this	PRON
fnp-3500	345	4	could	could	AUX
fnp-3500	345	5	also	also	ADV
fnp-3500	345	6	have	have	VERB
fnp-3500	345	7	implications	implication	NOUN
fnp-3500	345	8	for	for	ADP
fnp-3500	345	9	the	the	DET
fnp-3500	345	10	therapeutic	therapeutic	ADJ
fnp-3500	345	11	approach	approach	NOUN
fnp-3500	345	12	.	.	PUNCT
fnp-3500	345	13	  	  	SPACE
fnp-3500	346	1	piii-03	piii-03	PROPN
fnp-3500	346	2	free	free	ADJ
fnp-3500	346	3	neuropathol	neuropathol	NOUN
fnp-3500	346	4	2:22:40	2:22:40	NUM
fnp-3500	346	5	immunomodulatory	immunomodulatory	ADJ
fnp-3500	346	6	function	function	NOUN
fnp-3500	346	7	of	of	ADP
fnp-3500	346	8	gm	gm	PROPN
fnp-3500	346	9	-	-	PUNCT
fnp-3500	346	10	csf	csf	ADJ
fnp-3500	346	11	in	in	ADP
fnp-3500	346	12	idiopathic	idiopathic	ADJ
fnp-3500	346	13	inflammatory	inflammatory	ADJ
fnp-3500	346	14	myopathies	myopathy	NOUN
fnp-3500	346	15	d.	d.	PROPN
fnp-3500	346	16	cengiz1,2	cengiz1,2	PROPN
fnp-3500	346	17	,	,	PUNCT
fnp-3500	346	18	t.	t.	PROPN
fnp-3500	346	19	müntefering2	müntefering2	PROPN
fnp-3500	346	20	,	,	PUNCT
fnp-3500	346	21	j.	j.	PROPN
fnp-3500	346	22	schubert1	schubert1	PROPN
fnp-3500	346	23	,	,	PUNCT
fnp-3500	346	24	c.	c.	PROPN
fnp-3500	346	25	preuße3	preuße3	PROPN
fnp-3500	346	26	,	,	PUNCT
fnp-3500	346	27	w.	w.	PROPN
fnp-3500	346	28	stenzel3	stenzel3	PROPN
fnp-3500	346	29	,	,	PUNCT
fnp-3500	346	30	s.	s.	PROPN
fnp-3500	346	31	meuth2	meuth2	PROPN
fnp-3500	346	32	,	,	PUNCT
fnp-3500	346	33	t.	t.	PROPN
fnp-3500	346	34	ruck2	ruck2	PROPN
fnp-3500	346	35	1	1	NUM
fnp-3500	346	36	clinic	clinic	NOUN
fnp-3500	346	37	for	for	ADP
fnp-3500	346	38	neurology	neurology	NOUN
fnp-3500	346	39	with	with	ADP
fnp-3500	346	40	institute	institute	NOUN
fnp-3500	346	41	for	for	ADP
fnp-3500	346	42	translational	translational	ADJ
fnp-3500	346	43	neurology	neurology	NOUN
fnp-3500	346	44	,	,	PUNCT
fnp-3500	346	45	university	university	NOUN
fnp-3500	346	46	hospital	hospital	NOUN
fnp-3500	346	47	,	,	PUNCT
fnp-3500	346	48	münster	münster	NOUN
fnp-3500	346	49	,	,	PUNCT
fnp-3500	346	50	germany	germany	PROPN
fnp-3500	346	51	2	2	NUM
fnp-3500	346	52	heinrich	heinrich	PROPN
fnp-3500	346	53	-	-	PUNCT
fnp-3500	346	54	heine	heine	PROPN
fnp-3500	346	55	university	university	PROPN
fnp-3500	346	56	düsseldorf	düsseldorf	PROPN
fnp-3500	346	57	,	,	PUNCT
fnp-3500	346	58	department	department	PROPN
fnp-3500	346	59	of	of	ADP
fnp-3500	346	60	neurology	neurology	NOUN
fnp-3500	346	61	,	,	PUNCT
fnp-3500	346	62	medical	medical	ADJ
fnp-3500	346	63	faculty	faculty	NOUN
fnp-3500	346	64	,	,	PUNCT
fnp-3500	346	65	düsseldorf	düsseldorf	PROPN
fnp-3500	346	66	,	,	PUNCT
fnp-3500	346	67	germany	germany	PROPN
fnp-3500	346	68	3	3	NUM
fnp-3500	346	69	charité	charité	PROPN
fnp-3500	346	70	universitätsmedizin	universitätsmedizin	PROPN
fnp-3500	346	71	,	,	PUNCT
fnp-3500	346	72	department	department	NOUN
fnp-3500	346	73	of	of	ADP
fnp-3500	346	74	neuropathology	neuropathology	NOUN
fnp-3500	346	75	,	,	PUNCT
fnp-3500	346	76	berlin	berlin	PROPN
fnp-3500	346	77	,	,	PUNCT
fnp-3500	346	78	germany	germany	PROPN
fnp-3500	346	79	introduction	introduction	NOUN
fnp-3500	346	80	:	:	PUNCT
fnp-3500	346	81	idiopathic	idiopathic	ADJ
fnp-3500	346	82	inflammatory	inflammatory	ADJ
fnp-3500	346	83	myopathies	myopathy	NOUN
fnp-3500	346	84	(	(	PUNCT
fnp-3500	346	85	iims	iim	NOUN
fnp-3500	346	86	)	)	PUNCT
fnp-3500	346	87	are	be	AUX
fnp-3500	346	88	characterized	characterize	VERB
fnp-3500	346	89	by	by	ADP
fnp-3500	346	90	chronic	chronic	ADJ
fnp-3500	346	91	inflammation	inflammation	NOUN
fnp-3500	346	92	of	of	ADP
fnp-3500	346	93	the	the	DET
fnp-3500	346	94	muscle	muscle	NOUN
fnp-3500	346	95	,	,	PUNCT
fnp-3500	346	96	resulting	result	VERB
fnp-3500	346	97	in	in	ADP
fnp-3500	346	98	muscle	muscle	NOUN
fnp-3500	346	99	weakness	weakness	NOUN
fnp-3500	346	100	and	and	CCONJ
fnp-3500	346	101	pain	pain	NOUN
fnp-3500	346	102	.	.	PUNCT
fnp-3500	347	1	pathogenesis	pathogenesis	NOUN
fnp-3500	347	2	is	be	AUX
fnp-3500	347	3	driven	drive	VERB
fnp-3500	347	4	by	by	ADP
fnp-3500	347	5	the	the	DET
fnp-3500	347	6	interaction	interaction	NOUN
fnp-3500	347	7	of	of	ADP
fnp-3500	347	8	skeletal	skeletal	ADJ
fnp-3500	347	9	muscle	muscle	NOUN
fnp-3500	347	10	,	,	PUNCT
fnp-3500	347	11	muscle	muscle	NOUN
fnp-3500	347	12	endothelial	endothelial	ADJ
fnp-3500	347	13	and	and	CCONJ
fnp-3500	347	14	immune	immune	ADJ
fnp-3500	347	15	cells	cell	NOUN
fnp-3500	347	16	.	.	PUNCT
fnp-3500	348	1	cytokines	cytokine	NOUN
fnp-3500	348	2	play	play	VERB
fnp-3500	348	3	a	a	DET
fnp-3500	348	4	central	central	ADJ
fnp-3500	348	5	role	role	NOUN
fnp-3500	348	6	in	in	ADP
fnp-3500	348	7	controlling	control	VERB
fnp-3500	348	8	these	these	DET
fnp-3500	348	9	interactions	interaction	NOUN
fnp-3500	348	10	.	.	PUNCT
fnp-3500	349	1	gm	gm	ADJ
fnp-3500	349	2	-	-	PUNCT
fnp-3500	349	3	csf	csf	PROPN
fnp-3500	349	4	is	be	AUX
fnp-3500	349	5	a	a	DET
fnp-3500	349	6	cytokine	cytokine	NOUN
fnp-3500	349	7	,	,	PUNCT
fnp-3500	349	8	which	which	PRON
fnp-3500	349	9	is	be	AUX
fnp-3500	349	10	significantly	significantly	ADV
fnp-3500	349	11	involved	involve	VERB
fnp-3500	349	12	in	in	ADP
fnp-3500	349	13	the	the	DET
fnp-3500	349	14	development	development	NOUN
fnp-3500	349	15	of	of	ADP
fnp-3500	349	16	autoimmune	autoimmune	ADJ
fnp-3500	349	17	diseases	disease	NOUN
fnp-3500	349	18	and	and	CCONJ
fnp-3500	349	19	is	be	AUX
fnp-3500	349	20	currently	currently	ADV
fnp-3500	349	21	being	be	AUX
fnp-3500	349	22	investigated	investigate	VERB
fnp-3500	349	23	in	in	ADP
fnp-3500	349	24	clinical	clinical	ADJ
fnp-3500	349	25	trials	trial	NOUN
fnp-3500	349	26	for	for	ADP
fnp-3500	349	27	therapy	therapy	NOUN
fnp-3500	349	28	.	.	PUNCT
fnp-3500	350	1	objectives	objective	NOUN
fnp-3500	350	2	:	:	PUNCT
fnp-3500	350	3	the	the	DET
fnp-3500	350	4	role	role	NOUN
fnp-3500	350	5	of	of	ADP
fnp-3500	350	6	gm	gm	PROPN
fnp-3500	350	7	-	-	PUNCT
fnp-3500	350	8	csf	csf	NOUN
fnp-3500	350	9	in	in	ADP
fnp-3500	350	10	the	the	DET
fnp-3500	350	11	inflammatory	inflammatory	ADJ
fnp-3500	350	12	processes	process	NOUN
fnp-3500	350	13	of	of	ADP
fnp-3500	350	14	iims	iims	NOUN
fnp-3500	350	15	is	be	AUX
fnp-3500	350	16	largely	largely	ADV
fnp-3500	350	17	unknown	unknown	ADJ
fnp-3500	350	18	.	.	PUNCT
fnp-3500	351	1	therefore	therefore	ADV
fnp-3500	351	2	,	,	PUNCT
fnp-3500	351	3	the	the	DET
fnp-3500	351	4	aim	aim	NOUN
fnp-3500	351	5	of	of	ADP
fnp-3500	351	6	this	this	DET
fnp-3500	351	7	work	work	NOUN
fnp-3500	351	8	is	be	AUX
fnp-3500	351	9	to	to	PART
fnp-3500	351	10	investigate	investigate	VERB
fnp-3500	351	11	its	its	PRON
fnp-3500	351	12	immunomodulatory	immunomodulatory	ADJ
fnp-3500	351	13	function	function	NOUN
fnp-3500	351	14	.	.	PUNCT
fnp-3500	352	1	materials	material	NOUN
fnp-3500	352	2	&	&	CCONJ
fnp-3500	352	3	methods	method	NOUN
fnp-3500	352	4	:	:	PUNCT
fnp-3500	352	5	murine	murine	ADJ
fnp-3500	352	6	skeletal	skeletal	ADJ
fnp-3500	352	7	muscle	muscle	NOUN
fnp-3500	352	8	and	and	CCONJ
fnp-3500	352	9	endothelial	endothelial	NOUN
fnp-3500	352	10	cells	cell	NOUN
fnp-3500	352	11	were	be	AUX
fnp-3500	352	12	stimulated	stimulate	VERB
fnp-3500	352	13	with	with	ADP
fnp-3500	352	14	gm	gm	PROPN
fnp-3500	352	15	-	-	PUNCT
fnp-3500	352	16	csf	csf	ADJ
fnp-3500	352	17	and	and	CCONJ
fnp-3500	352	18	other	other	ADJ
fnp-3500	352	19	proand	proand	ADJ
fnp-3500	352	20	anti	anti	ADJ
fnp-3500	352	21	-	-	ADJ
fnp-3500	352	22	inflammatory	inflammatory	ADJ
fnp-3500	352	23	cytokines	cytokine	NOUN
fnp-3500	352	24	.	.	PUNCT
fnp-3500	353	1	to	to	PART
fnp-3500	353	2	analyze	analyze	VERB
fnp-3500	353	3	the	the	DET
fnp-3500	353	4	impact	impact	NOUN
fnp-3500	353	5	of	of	ADP
fnp-3500	353	6	these	these	DET
fnp-3500	353	7	conditions	condition	NOUN
fnp-3500	353	8	,	,	PUNCT
fnp-3500	353	9	flow	flow	VERB
fnp-3500	353	10	cytometric	cytometric	ADJ
fnp-3500	353	11	analysis	analysis	NOUN
fnp-3500	353	12	was	be	AUX
fnp-3500	353	13	performed	perform	VERB
fnp-3500	353	14	.	.	PUNCT
fnp-3500	354	1	furthermore	furthermore	ADV
fnp-3500	354	2	,	,	PUNCT
fnp-3500	354	3	the	the	DET
fnp-3500	354	4	immunological	immunological	ADJ
fnp-3500	354	5	relevance	relevance	NOUN
fnp-3500	354	6	of	of	ADP
fnp-3500	354	7	gm	gm	PROPN
fnp-3500	354	8	-	-	PUNCT
fnp-3500	354	9	csf	csf	ADJ
fnp-3500	354	10	on	on	ADP
fnp-3500	354	11	immune	immune	ADJ
fnp-3500	354	12	cell	cell	NOUN
fnp-3500	354	13	migration	migration	NOUN
fnp-3500	354	14	and	and	CCONJ
fnp-3500	354	15	adhesion	adhesion	NOUN
fnp-3500	354	16	were	be	AUX
fnp-3500	354	17	investigated	investigate	VERB
fnp-3500	354	18	.	.	PUNCT
fnp-3500	355	1	the	the	DET
fnp-3500	355	2	expression	expression	NOUN
fnp-3500	355	3	of	of	ADP
fnp-3500	355	4	gm	gm	PROPN
fnp-3500	355	5	-	-	PUNCT
fnp-3500	355	6	csf	csf	PROPN
fnp-3500	355	7	was	be	AUX
fnp-3500	355	8	also	also	ADV
fnp-3500	355	9	evaluated	evaluate	VERB
fnp-3500	355	10	in	in	ADP
fnp-3500	355	11	human	human	ADJ
fnp-3500	355	12	muscle	muscle	NOUN
fnp-3500	355	13	biopsies	biopsy	NOUN
fnp-3500	355	14	of	of	ADP
fnp-3500	355	15	iim	iim	NOUN
fnp-3500	355	16	patients	patient	NOUN
fnp-3500	355	17	.	.	PUNCT
fnp-3500	356	1	results	result	NOUN
fnp-3500	356	2	:	:	PUNCT
fnp-3500	356	3	stimulation	stimulation	VERB
fnp-3500	356	4	with	with	ADP
fnp-3500	356	5	proand	proand	NOUN
fnp-3500	356	6	anti	anti	ADJ
fnp-3500	356	7	-	-	ADJ
fnp-3500	356	8	inflammatory	inflammatory	ADJ
fnp-3500	356	9	cytokines	cytokine	NOUN
fnp-3500	356	10	regulate	regulate	VERB
fnp-3500	356	11	the	the	DET
fnp-3500	356	12	expression	expression	NOUN
fnp-3500	356	13	of	of	ADP
fnp-3500	356	14	gm	gm	PROPN
fnp-3500	356	15	-	-	PUNCT
fnp-3500	356	16	csf	csf	NOUN
fnp-3500	356	17	and	and	CCONJ
fnp-3500	356	18	the	the	DET
fnp-3500	356	19	gm	gm	NOUN
fnp-3500	356	20	-	-	PUNCT
fnp-3500	356	21	csf	csf	ADJ
fnp-3500	356	22	receptor	receptor	NOUN
fnp-3500	356	23	in	in	ADP
fnp-3500	356	24	muscle	muscle	NOUN
fnp-3500	356	25	and	and	CCONJ
fnp-3500	356	26	endothelial	endothelial	NOUN
fnp-3500	356	27	cells	cell	NOUN
fnp-3500	356	28	.	.	PUNCT
fnp-3500	357	1	gm	gm	ADJ
fnp-3500	357	2	-	-	PUNCT
fnp-3500	357	3	csf	csf	NOUN
fnp-3500	357	4	led	lead	VERB
fnp-3500	357	5	to	to	ADP
fnp-3500	357	6	increased	increase	VERB
fnp-3500	357	7	expression	expression	NOUN
fnp-3500	357	8	of	of	ADP
fnp-3500	357	9	costimulatory	costimulatory	ADJ
fnp-3500	357	10	molecules	molecule	NOUN
fnp-3500	357	11	on	on	ADP
fnp-3500	357	12	skeletal	skeletal	ADJ
fnp-3500	357	13	muscle	muscle	NOUN
fnp-3500	357	14	cells	cell	NOUN
fnp-3500	357	15	,	,	PUNCT
fnp-3500	357	16	as	as	ADV
fnp-3500	357	17	well	well	ADV
fnp-3500	357	18	as	as	ADP
fnp-3500	357	19	decreased	decrease	VERB
fnp-3500	357	20	expression	expression	NOUN
fnp-3500	357	21	of	of	ADP
fnp-3500	357	22	adhesion	adhesion	NOUN
fnp-3500	357	23	molecules	molecule	NOUN
fnp-3500	357	24	on	on	ADP
fnp-3500	357	25	endothelial	endothelial	ADJ
fnp-3500	357	26	cells	cell	NOUN
fnp-3500	357	27	.	.	PUNCT
fnp-3500	358	1	stimulation	stimulation	NOUN
fnp-3500	358	2	also	also	ADV
fnp-3500	358	3	resulted	result	VERB
fnp-3500	358	4	in	in	ADP
fnp-3500	358	5	increased	increase	VERB
fnp-3500	358	6	immune	immune	ADJ
fnp-3500	358	7	cell	cell	NOUN
fnp-3500	358	8	migration	migration	NOUN
fnp-3500	358	9	across	across	ADP
fnp-3500	358	10	muscle	muscle	NOUN
fnp-3500	358	11	endothelial	endothelial	ADJ
fnp-3500	358	12	barriers	barrier	NOUN
fnp-3500	358	13	.	.	PUNCT
fnp-3500	359	1	in	in	ADP
fnp-3500	359	2	human	human	ADJ
fnp-3500	359	3	muscle	muscle	NOUN
fnp-3500	359	4	biopsies	biopsy	NOUN
fnp-3500	359	5	of	of	ADP
fnp-3500	359	6	iim	iim	NOUN
fnp-3500	359	7	patients	patient	NOUN
fnp-3500	359	8	,	,	PUNCT
fnp-3500	359	9	histological	histological	ADJ
fnp-3500	359	10	analysis	analysis	NOUN
fnp-3500	359	11	revealed	reveal	VERB
fnp-3500	359	12	high	high	ADJ
fnp-3500	359	13	expression	expression	NOUN
fnp-3500	359	14	of	of	ADP
fnp-3500	359	15	gm	gm	PROPN
fnp-3500	359	16	-	-	PUNCT
fnp-3500	359	17	csf	csf	PROPN
fnp-3500	359	18	.	.	PROPN
fnp-3500	359	19	conclusion	conclusion	NOUN
fnp-3500	359	20	:	:	PUNCT
fnp-3500	359	21	the	the	DET
fnp-3500	359	22	gm	gm	PROPN
fnp-3500	359	23	-	-	PUNCT
fnp-3500	359	24	csf	csf	ADJ
fnp-3500	359	25	signaling	signal	VERB
fnp-3500	359	26	pathway	pathway	NOUN
fnp-3500	359	27	affects	affect	VERB
fnp-3500	359	28	the	the	DET
fnp-3500	359	29	cellular	cellular	ADJ
fnp-3500	359	30	interactions	interaction	NOUN
fnp-3500	359	31	of	of	ADP
fnp-3500	359	32	muscle	muscle	NOUN
fnp-3500	359	33	,	,	PUNCT
fnp-3500	359	34	endothelial	endothelial	NOUN
fnp-3500	359	35	,	,	PUNCT
fnp-3500	359	36	and	and	CCONJ
fnp-3500	359	37	immune	immune	ADJ
fnp-3500	359	38	cells	cell	NOUN
fnp-3500	359	39	in	in	ADP
fnp-3500	359	40	the	the	DET
fnp-3500	359	41	skeletal	skeletal	ADJ
fnp-3500	359	42	muscle	muscle	NOUN
fnp-3500	359	43	.	.	PUNCT
fnp-3500	360	1	these	these	DET
fnp-3500	360	2	findings	finding	NOUN
fnp-3500	360	3	could	could	AUX
fnp-3500	360	4	contribute	contribute	VERB
fnp-3500	360	5	to	to	PART
fnp-3500	360	6	elucidate	elucidate	VERB
fnp-3500	360	7	autoimmune	autoimmune	ADJ
fnp-3500	360	8	processes	process	NOUN
fnp-3500	360	9	in	in	ADP
fnp-3500	360	10	iims	iim	NOUN
fnp-3500	360	11	and	and	CCONJ
fnp-3500	360	12	identify	identify	VERB
fnp-3500	360	13	new	new	ADJ
fnp-3500	360	14	therapeutic	therapeutic	ADJ
fnp-3500	360	15	targets	target	NOUN
fnp-3500	360	16	.	.	PUNCT
fnp-3500	360	17	  	  	SPACE
fnp-3500	361	1	piii-04	piii-04	ADJ
fnp-3500	361	2	free	free	ADJ
fnp-3500	361	3	neuropathol	neuropathol	NOUN
fnp-3500	361	4	2:22:41	2:22:41	NUM
fnp-3500	361	5	effect	effect	NOUN
fnp-3500	361	6	of	of	ADP
fnp-3500	361	7	vasoactive	vasoactive	ADJ
fnp-3500	361	8	therapy	therapy	NOUN
fnp-3500	361	9	in	in	ADP
fnp-3500	361	10	patients	patient	NOUN
fnp-3500	361	11	with	with	ADP
fnp-3500	361	12	systemic	systemic	ADJ
fnp-3500	361	13	sclerosis	sclerosis	NOUN
fnp-3500	361	14	on	on	ADP
fnp-3500	361	15	dermal	dermal	ADJ
fnp-3500	361	16	small	small	ADJ
fnp-3500	361	17	nerve	nerve	NOUN
fnp-3500	361	18	fibers	fiber	NOUN
fnp-3500	361	19	,	,	PUNCT
fnp-3500	361	20	langerhans	langerhan	NOUN
fnp-3500	361	21	-	-	NOUN
fnp-3500	361	22	cells	cell	NOUN
fnp-3500	361	23	and	and	CCONJ
fnp-3500	361	24	vessel	vessel	NOUN
fnp-3500	361	25	density	density	NOUN
fnp-3500	361	26	.	.	PUNCT
fnp-3500	362	1	l.	l.	PROPN
fnp-3500	362	2	bajors1	bajors1	PROPN
fnp-3500	362	3	,	,	PUNCT
fnp-3500	362	4	f.	f.	PROPN
fnp-3500	362	5	höcketstaller2	höcketstaller2	PROPN
fnp-3500	362	6	,	,	PUNCT
fnp-3500	362	7	m.	m.	PROPN
fnp-3500	362	8	köhm2,3	köhm2,3	PROPN
fnp-3500	362	9	,	,	PUNCT
fnp-3500	362	10	s.	s.	PROPN
fnp-3500	362	11	seidel4	seidel4	PROPN
fnp-3500	362	12	,	,	PUNCT
fnp-3500	362	13	r.	r.	PROPN
fnp-3500	362	14	wolf5	wolf5	PROPN
fnp-3500	362	15	,	,	PUNCT
fnp-3500	362	16	a.	a.	NOUN
fnp-3500	362	17	roth1	roth1	PROPN
fnp-3500	362	18	,	,	PUNCT
fnp-3500	362	19	u.	u.	PROPN
fnp-3500	362	20	drott2,6	drott2,6	PROPN
fnp-3500	362	21	,	,	PUNCT
fnp-3500	362	22	a.	a.	NOUN
fnp-3500	362	23	schänzer1	schänzer1	PROPN
fnp-3500	363	1	1	1	NUM
fnp-3500	363	2	justus	justus	PROPN
fnp-3500	363	3	-	-	PUNCT
fnp-3500	363	4	liebig	liebig	NOUN
fnp-3500	363	5	-	-	PUNCT
fnp-3500	363	6	university	university	NOUN
fnp-3500	363	7	gießen	gießen	NOUN
fnp-3500	363	8	,	,	PUNCT
fnp-3500	363	9	institute	institute	NOUN
fnp-3500	363	10	of	of	ADP
fnp-3500	363	11	neuropathology	neuropathology	NOUN
fnp-3500	363	12	,	,	PUNCT
fnp-3500	363	13	gießen	gießen	PROPN
fnp-3500	363	14	,	,	PUNCT
fnp-3500	363	15	germany	germany	PROPN
fnp-3500	363	16	2	2	NUM
fnp-3500	363	17	goethe	goethe	PROPN
fnp-3500	363	18	university	university	PROPN
fnp-3500	363	19	frankfurt	frankfurt	PROPN
fnp-3500	363	20	,	,	PUNCT
fnp-3500	363	21	department	department	NOUN
fnp-3500	363	22	of	of	ADP
fnp-3500	363	23	rheumatology	rheumatology	NOUN
fnp-3500	363	24	,	,	PUNCT
fnp-3500	363	25	frankfurt	frankfurt	PROPN
fnp-3500	363	26	a.	a.	NOUN
fnp-3500	363	27	m.	m.	PROPN
fnp-3500	363	28	,	,	PUNCT
fnp-3500	363	29	germany	germany	PROPN
fnp-3500	363	30	3	3	NUM
fnp-3500	363	31	goethe	goethe	PROPN
fnp-3500	363	32	university	university	PROPN
fnp-3500	363	33	frankfurt	frankfurt	PROPN
fnp-3500	363	34	,	,	PUNCT
fnp-3500	363	35	fraunhofer	fraunhofer	PROPN
fnp-3500	363	36	project	project	PROPN
fnp-3500	363	37	group	group	NOUN
fnp-3500	363	38	translational	translational	ADJ
fnp-3500	363	39	medicine	medicine	NOUN
fnp-3500	363	40	and	and	CCONJ
fnp-3500	363	41	pharmacology	pharmacology	NOUN
fnp-3500	363	42	,	,	PUNCT
fnp-3500	363	43	ime	ime	PROPN
fnp-3500	363	44	,	,	PUNCT
fnp-3500	363	45	frankfurt	frankfurt	PROPN
fnp-3500	363	46	a.	a.	NOUN
fnp-3500	363	47	m.	m.	PROPN
fnp-3500	363	48	,	,	PUNCT
fnp-3500	363	49	germany	germany	PROPN
fnp-3500	363	50	4	4	NUM
fnp-3500	363	51	goethe	goethe	PROPN
fnp-3500	363	52	university	university	PROPN
fnp-3500	363	53	frankfurt	frankfurt	PROPN
fnp-3500	363	54	,	,	PUNCT
fnp-3500	363	55	institute	institute	NOUN
fnp-3500	363	56	of	of	ADP
fnp-3500	363	57	cell	cell	NOUN
fnp-3500	363	58	biology	biology	NOUN
fnp-3500	363	59	and	and	CCONJ
fnp-3500	363	60	neuroscience	neuroscience	NOUN
fnp-3500	363	61	and	and	CCONJ
fnp-3500	363	62	buchmann	buchmann	PROPN
fnp-3500	363	63	institute	institute	PROPN
fnp-3500	363	64	for	for	ADP
fnp-3500	363	65	molecular	molecular	ADJ
fnp-3500	363	66	life	life	NOUN
fnp-3500	363	67	sciences	science	NOUN
fnp-3500	363	68	(	(	PUNCT
fnp-3500	363	69	bmls	bmls	NOUN
fnp-3500	363	70	)	)	PUNCT
fnp-3500	363	71	,	,	PUNCT
fnp-3500	363	72	frankfurt	frankfurt	PROPN
fnp-3500	363	73	a.	a.	NOUN
fnp-3500	363	74	m.	m.	PROPN
fnp-3500	363	75	,	,	PUNCT
fnp-3500	363	76	germany	germany	PROPN
fnp-3500	363	77	5	5	NUM
fnp-3500	363	78	philipps	philipps	PROPN
fnp-3500	363	79	university	university	PROPN
fnp-3500	363	80	marburg	marburg	PROPN
fnp-3500	363	81	,	,	PUNCT
fnp-3500	363	82	department	department	NOUN
fnp-3500	363	83	of	of	ADP
fnp-3500	363	84	dermatology	dermatology	NOUN
fnp-3500	363	85	and	and	CCONJ
fnp-3500	363	86	allergology	allergology	NOUN
fnp-3500	363	87	,	,	PUNCT
fnp-3500	363	88	marburg	marburg	PROPN
fnp-3500	363	89	,	,	PUNCT
fnp-3500	363	90	germany	germany	PROPN
fnp-3500	363	91	6	6	NUM
fnp-3500	363	92	median	median	PROPN
fnp-3500	363	93	klinik	klinik	PROPN
fnp-3500	363	94	schlangenbad	schlangenbad	PROPN
fnp-3500	363	95	,	,	PUNCT
fnp-3500	363	96	department	department	NOUN
fnp-3500	363	97	of	of	ADP
fnp-3500	363	98	rheumatology	rheumatology	PROPN
fnp-3500	363	99	,	,	PUNCT
fnp-3500	363	100	wiesbaden	wiesbaden	PROPN
fnp-3500	363	101	,	,	PUNCT
fnp-3500	363	102	germany	germany	PROPN
fnp-3500	363	103	introduction	introduction	NOUN
fnp-3500	363	104	:	:	PUNCT
fnp-3500	363	105	systemic	systemic	ADJ
fnp-3500	363	106	sclerosis	sclerosis	NOUN
fnp-3500	363	107	(	(	PUNCT
fnp-3500	363	108	ssc	ssc	NOUN
fnp-3500	363	109	)	)	PUNCT
fnp-3500	363	110	is	be	AUX
fnp-3500	363	111	an	an	DET
fnp-3500	363	112	orphan	orphan	NOUN
fnp-3500	363	113	immune	immune	NOUN
fnp-3500	363	114	-	-	PUNCT
fnp-3500	363	115	mediated	mediate	VERB
fnp-3500	363	116	disease	disease	NOUN
fnp-3500	363	117	affecting	affect	VERB
fnp-3500	363	118	multiple	multiple	ADJ
fnp-3500	363	119	organ	organ	NOUN
fnp-3500	363	120	systems	system	NOUN
fnp-3500	363	121	.	.	PUNCT
fnp-3500	364	1	most	most	ADV
fnp-3500	364	2	commonly	commonly	ADV
fnp-3500	364	3	,	,	PUNCT
fnp-3500	364	4	clinical	clinical	ADJ
fnp-3500	364	5	symptoms	symptom	NOUN
fnp-3500	364	6	such	such	ADJ
fnp-3500	364	7	as	as	ADP
fnp-3500	364	8	skin	skin	NOUN
fnp-3500	364	9	fibrosis	fibrosis	NOUN
fnp-3500	364	10	and	and	CCONJ
fnp-3500	364	11	digital	digital	ADJ
fnp-3500	364	12	ulceration	ulceration	NOUN
fnp-3500	364	13	occur	occur	VERB
fnp-3500	364	14	early	early	ADV
fnp-3500	364	15	in	in	ADP
fnp-3500	364	16	disease	disease	NOUN
fnp-3500	364	17	course	course	NOUN
fnp-3500	364	18	.	.	PUNCT
fnp-3500	365	1	here	here	ADV
fnp-3500	365	2	,	,	PUNCT
fnp-3500	365	3	vasculopathy	vasculopathy	NOUN
fnp-3500	365	4	is	be	AUX
fnp-3500	365	5	an	an	DET
fnp-3500	365	6	underlying	underlie	VERB
fnp-3500	365	7	aetiology	aetiology	NOUN
fnp-3500	365	8	.	.	PUNCT
fnp-3500	366	1	additional	additional	ADJ
fnp-3500	366	2	,	,	PUNCT
fnp-3500	366	3	small	small	ADJ
fnp-3500	366	4	nerve	nerve	NOUN
fnp-3500	366	5	fibers	fiber	NOUN
fnp-3500	366	6	(	(	PUNCT
fnp-3500	366	7	snf	snf	PROPN
fnp-3500	366	8	)	)	PUNCT
fnp-3500	366	9	might	might	AUX
fnp-3500	366	10	be	be	AUX
fnp-3500	366	11	affected	affect	VERB
fnp-3500	366	12	in	in	ADP
fnp-3500	366	13	in	in	ADP
fnp-3500	366	14	ssc	ssc	NOUN
fnp-3500	366	15	patients	patient	NOUN
fnp-3500	366	16	and	and	CCONJ
fnp-3500	366	17	contribute	contribute	VERB
fnp-3500	366	18	to	to	ADP
fnp-3500	366	19	disease	disease	NOUN
fnp-3500	366	20	progression	progression	NOUN
fnp-3500	366	21	.	.	PUNCT
fnp-3500	367	1	material	material	NOUN
fnp-3500	367	2	and	and	CCONJ
fnp-3500	367	3	methods	method	NOUN
fnp-3500	367	4	:	:	PUNCT
fnp-3500	367	5	21	21	NUM
fnp-3500	367	6	ssc	ssc	NOUN
fnp-3500	367	7	patients	patient	NOUN
fnp-3500	367	8	received	receive	VERB
fnp-3500	367	9	intravenous	intravenous	ADJ
fnp-3500	367	10	medication	medication	NOUN
fnp-3500	367	11	iloprost	iloprost	NOUN
fnp-3500	367	12	for	for	ADP
fnp-3500	367	13	10	10	NUM
fnp-3500	367	14	days	day	NOUN
fnp-3500	367	15	(	(	PUNCT
fnp-3500	367	16	95	95	NUM
fnp-3500	367	17	%	%	NOUN
fnp-3500	367	18	females	female	NOUN
fnp-3500	367	19	;	;	PUNCT
fnp-3500	367	20	56,1±11,9	56,1±11,9	NUM
fnp-3500	367	21	years	year	NOUN
fnp-3500	367	22	)	)	PUNCT
fnp-3500	367	23	.	.	PUNCT
fnp-3500	368	1	7	7	NUM
fnp-3500	368	2	healthy	healthy	ADJ
fnp-3500	368	3	subjects	subject	NOUN
fnp-3500	368	4	served	serve	VERB
fnp-3500	368	5	as	as	ADP
fnp-3500	368	6	controls	control	NOUN
fnp-3500	368	7	(	(	PUNCT
fnp-3500	368	8	71	71	NUM
fnp-3500	368	9	%	%	NOUN
fnp-3500	368	10	f	f	X
fnp-3500	368	11	;	;	PUNCT
fnp-3500	368	12	51,6±18,3	51,6±18,3	NUM
fnp-3500	368	13	y	y	NOUN
fnp-3500	368	14	)	)	PUNCT
fnp-3500	368	15	.	.	PUNCT
fnp-3500	369	1	skin	skin	NOUN
fnp-3500	369	2	biopsies	biopsy	NOUN
fnp-3500	369	3	were	be	AUX
fnp-3500	369	4	taken	take	VERB
fnp-3500	369	5	from	from	ADP
fnp-3500	369	6	the	the	DET
fnp-3500	369	7	volar	volar	ADJ
fnp-3500	369	8	forearm	forearm	NOUN
fnp-3500	369	9	before	before	ADV
fnp-3500	369	10	and	and	CCONJ
fnp-3500	369	11	3	3	NUM
fnp-3500	369	12	months	month	NOUN
fnp-3500	369	13	after	after	ADP
fnp-3500	369	14	treatment	treatment	NOUN
fnp-3500	369	15	.	.	PUNCT
fnp-3500	370	1	epidermal	epidermal	ADJ
fnp-3500	370	2	nerve	nerve	NOUN
fnp-3500	370	3	density	density	NOUN
fnp-3500	370	4	(	(	PUNCT
fnp-3500	370	5	end	end	NOUN
fnp-3500	370	6	)	)	PUNCT
fnp-3500	370	7	,	,	PUNCT
fnp-3500	370	8	langerhans	langerhans	PROPN
fnp-3500	370	9	cells	cell	NOUN
fnp-3500	370	10	(	(	PUNCT
fnp-3500	370	11	lc	lc	NOUN
fnp-3500	370	12	)	)	PUNCT
fnp-3500	370	13	and	and	CCONJ
fnp-3500	370	14	vessel	vessel	NOUN
fnp-3500	370	15	density	density	NOUN
fnp-3500	370	16	(	(	PUNCT
fnp-3500	370	17	vd	vd	NOUN
fnp-3500	370	18	)	)	PUNCT
fnp-3500	370	19	were	be	AUX
fnp-3500	370	20	analysed	analyse	VERB
fnp-3500	370	21	at	at	ADP
fnp-3500	370	22	immunofluorescence	immunofluorescence	NOUN
fnp-3500	370	23	-	-	PUNCT
fnp-3500	370	24	stained	stain	VERB
fnp-3500	370	25	sections	section	NOUN
fnp-3500	370	26	using	use	VERB
fnp-3500	370	27	a	a	DET
fnp-3500	370	28	zeiss	zeiss	ADJ
fnp-3500	370	29	axioscanner	axioscanner	NOUN
fnp-3500	370	30	and	and	CCONJ
fnp-3500	370	31	imagej	imagej	ADJ
fnp-3500	370	32	software	software	NOUN
fnp-3500	370	33	.	.	PUNCT
fnp-3500	371	1	the	the	DET
fnp-3500	371	2	skin	skin	NOUN
fnp-3500	371	3	pathology	pathology	NOUN
fnp-3500	371	4	was	be	AUX
fnp-3500	371	5	categorized	categorize	VERB
fnp-3500	371	6	with	with	ADP
fnp-3500	371	7	a	a	DET
fnp-3500	371	8	histological	histological	ADJ
fnp-3500	371	9	skin	skin	NOUN
fnp-3500	371	10	score	score	NOUN
fnp-3500	371	11	.	.	PUNCT
fnp-3500	372	1	results	result	NOUN
fnp-3500	372	2	:	:	PUNCT
fnp-3500	372	3	the	the	DET
fnp-3500	372	4	ssc	ssc	PROPN
fnp-3500	372	5	group	group	NOUN
fnp-3500	372	6	showed	show	VERB
fnp-3500	372	7	no	no	DET
fnp-3500	372	8	significant	significant	ADJ
fnp-3500	372	9	difference	difference	NOUN
fnp-3500	372	10	of	of	ADP
fnp-3500	372	11	end	end	NOUN
fnp-3500	372	12	and	and	CCONJ
fnp-3500	372	13	lc	lc	NOUN
fnp-3500	372	14	density	density	NOUN
fnp-3500	372	15	(	(	PUNCT
fnp-3500	372	16	13,09±4,26	13,09±4,26	NUM
fnp-3500	372	17	snf	snf	PROPN
fnp-3500	372	18	/	/	SYM
fnp-3500	372	19	mm	mm	PROPN
fnp-3500	372	20	;	;	PUNCT
fnp-3500	372	21	259,8±121,5	259,8±121,5	NUM
fnp-3500	372	22	lc	lc	PROPN
fnp-3500	372	23	/	/	SYM
fnp-3500	372	24	mm²	mm²	PROPN
fnp-3500	372	25	)	)	PUNCT
fnp-3500	372	26	compared	compare	VERB
fnp-3500	372	27	to	to	ADP
fnp-3500	372	28	controls	control	NOUN
fnp-3500	372	29	(	(	PUNCT
fnp-3500	372	30	10,8±3,11	10,8±3,11	NUM
fnp-3500	372	31	sfn	sfn	PROPN
fnp-3500	372	32	/	/	SYM
fnp-3500	372	33	mm	mm	PROPN
fnp-3500	372	34	,	,	PUNCT
fnp-3500	372	35	p=0,198	p=0,198	PROPN
fnp-3500	372	36	;	;	PUNCT
fnp-3500	372	37	335,4±124,86	335,4±124,86	NUM
fnp-3500	372	38	lc	lc	PROPN
fnp-3500	372	39	/	/	SYM
fnp-3500	372	40	mm²	mm²	PROPN
fnp-3500	372	41	,	,	PUNCT
fnp-3500	372	42	p=0,091	p=0,091	ADJ
fnp-3500	372	43	)	)	PUNCT
fnp-3500	372	44	or	or	CCONJ
fnp-3500	372	45	after	after	ADP
fnp-3500	372	46	treatment	treatment	NOUN
fnp-3500	372	47	(	(	PUNCT
fnp-3500	372	48	12,71±5,82	12,71±5,82	NUM
fnp-3500	372	49	snf	snf	PROPN
fnp-3500	372	50	/	/	SYM
fnp-3500	372	51	mm	mm	PROPN
fnp-3500	372	52	,	,	PUNCT
fnp-3500	372	53	p=0,49	p=0,49	PROPN
fnp-3500	372	54	;	;	PUNCT
fnp-3500	372	55	305,4±98,5	305,4±98,5	NUM
fnp-3500	372	56	lc	lc	PROPN
fnp-3500	372	57	/	/	SYM
fnp-3500	372	58	mm²	mm²	PROPN
fnp-3500	372	59	,	,	PUNCT
fnp-3500	372	60	p=0,098	p=0,098	PROPN
fnp-3500	372	61	)	)	PUNCT
fnp-3500	372	62	.	.	PUNCT
fnp-3500	373	1	the	the	DET
fnp-3500	373	2	vd	vd	NOUN
fnp-3500	373	3	was	be	AUX
fnp-3500	373	4	significantly	significantly	ADV
fnp-3500	373	5	increased	increase	VERB
fnp-3500	373	6	in	in	ADP
fnp-3500	373	7	the	the	DET
fnp-3500	373	8	ssc	ssc	NOUN
fnp-3500	373	9	group	group	NOUN
fnp-3500	373	10	compared	compare	VERB
fnp-3500	373	11	to	to	ADP
fnp-3500	373	12	controls	control	NOUN
fnp-3500	373	13	(	(	PUNCT
fnp-3500	373	14	3,01±1,10µm²/100µm²	3,01±1,10µm²/100µm²	NUM
fnp-3500	373	15	;	;	PUNCT
fnp-3500	373	16	2,18±1,12µm²/100µm²	2,18±1,12µm²/100µm²	NUM
fnp-3500	373	17	;	;	PUNCT
fnp-3500	373	18	p=0,046	p=0,046	NOUN
fnp-3500	373	19	)	)	PUNCT
fnp-3500	373	20	.	.	PUNCT
fnp-3500	374	1	in	in	ADP
fnp-3500	374	2	the	the	DET
fnp-3500	374	3	ssc	ssc	NOUN
fnp-3500	374	4	group	group	NOUN
fnp-3500	374	5	,	,	PUNCT
fnp-3500	374	6	the	the	DET
fnp-3500	374	7	vd	vd	NOUN
fnp-3500	374	8	was	be	AUX
fnp-3500	374	9	significantly	significantly	ADV
fnp-3500	374	10	decreased	decrease	VERB
fnp-3500	374	11	after	after	ADP
fnp-3500	374	12	treatment	treatment	NOUN
fnp-3500	374	13	(	(	PUNCT
fnp-3500	374	14	2,51±0,78µm²/100µm²	2,51±0,78µm²/100µm²	NUM
fnp-3500	374	15	;	;	PUNCT
fnp-3500	374	16	p=0,044	p=0,044	PROPN
fnp-3500	374	17	)	)	PUNCT
fnp-3500	374	18	.	.	PUNCT
fnp-3500	375	1	the	the	DET
fnp-3500	375	2	histological	histological	ADJ
fnp-3500	375	3	skin	skin	NOUN
fnp-3500	375	4	score	score	NOUN
fnp-3500	375	5	showed	show	VERB
fnp-3500	375	6	overall	overall	ADJ
fnp-3500	375	7	low	low	ADJ
fnp-3500	375	8	fibrotic	fibrotic	ADJ
fnp-3500	375	9	alterations	alteration	NOUN
fnp-3500	375	10	in	in	ADP
fnp-3500	375	11	both	both	DET
fnp-3500	375	12	groups	group	NOUN
fnp-3500	375	13	.	.	PUNCT
fnp-3500	376	1	conclusion	conclusion	NOUN
fnp-3500	376	2	:	:	PUNCT
fnp-3500	376	3	in	in	ADP
fnp-3500	376	4	our	our	PRON
fnp-3500	376	5	study	study	NOUN
fnp-3500	376	6	,	,	PUNCT
fnp-3500	376	7	ssc	ssc	PROPN
fnp-3500	376	8	patients	patient	NOUN
fnp-3500	376	9	showed	show	VERB
fnp-3500	376	10	a	a	DET
fnp-3500	376	11	higher	high	ADJ
fnp-3500	376	12	vd	vd	NOUN
fnp-3500	376	13	compared	compare	VERB
fnp-3500	376	14	to	to	ADP
fnp-3500	376	15	controls	control	NOUN
fnp-3500	376	16	and	and	CCONJ
fnp-3500	376	17	vd	vd	NOUN
fnp-3500	376	18	was	be	AUX
fnp-3500	376	19	affected	affect	VERB
fnp-3500	376	20	during	during	ADP
fnp-3500	376	21	short	short	ADJ
fnp-3500	376	22	-	-	PUNCT
fnp-3500	376	23	term	term	NOUN
fnp-3500	376	24	iloprost	iloprost	NOUN
fnp-3500	376	25	-	-	NOUN
fnp-3500	376	26	therapy	therapy	NOUN
fnp-3500	376	27	.	.	PUNCT
fnp-3500	377	1	megacapillaries	megacapillarie	NOUN
fnp-3500	377	2	is	be	AUX
fnp-3500	377	3	a	a	DET
fnp-3500	377	4	key	key	ADJ
fnp-3500	377	5	feature	feature	NOUN
fnp-3500	377	6	of	of	ADP
fnp-3500	377	7	ssc	ssc	NOUN
fnp-3500	377	8	and	and	CCONJ
fnp-3500	377	9	the	the	DET
fnp-3500	377	10	results	result	NOUN
fnp-3500	377	11	should	should	AUX
fnp-3500	377	12	be	be	AUX
fnp-3500	377	13	correlated	correlate	VERB
fnp-3500	377	14	with	with	ADP
fnp-3500	377	15	results	result	NOUN
fnp-3500	377	16	of	of	ADP
fnp-3500	377	17	capillary	capillary	ADJ
fnp-3500	377	18	microscopy	microscopy	NOUN
fnp-3500	377	19	.	.	PUNCT
fnp-3500	378	1	end	end	NOUN
fnp-3500	378	2	and	and	CCONJ
fnp-3500	378	3	lc	lc	NOUN
fnp-3500	378	4	were	be	AUX
fnp-3500	378	5	not	not	PART
fnp-3500	378	6	altered	alter	VERB
fnp-3500	378	7	during	during	ADP
fnp-3500	378	8	treatment	treatment	NOUN
fnp-3500	378	9	in	in	ADP
fnp-3500	378	10	ssc	ssc	NOUN
fnp-3500	378	11	patients	patient	NOUN
fnp-3500	378	12	.	.	PUNCT
fnp-3500	379	1	maybe	maybe	ADV
fnp-3500	379	2	these	these	DET
fnp-3500	379	3	findings	finding	NOUN
fnp-3500	379	4	depend	depend	VERB
fnp-3500	379	5	on	on	ADP
fnp-3500	379	6	the	the	DET
fnp-3500	379	7	low	low	ADJ
fnp-3500	379	8	skin	skin	NOUN
fnp-3500	379	9	score	score	NOUN
fnp-3500	379	10	showed	show	VERB
fnp-3500	379	11	in	in	ADP
fnp-3500	379	12	the	the	DET
fnp-3500	379	13	patients	patient	NOUN
fnp-3500	379	14	.	.	PUNCT
fnp-3500	380	1	to	to	PART
fnp-3500	380	2	investigate	investigate	VERB
fnp-3500	380	3	further	further	ADJ
fnp-3500	380	4	correlations	correlation	NOUN
fnp-3500	380	5	,	,	PUNCT
fnp-3500	380	6	the	the	DET
fnp-3500	380	7	results	result	NOUN
fnp-3500	380	8	will	will	AUX
fnp-3500	380	9	be	be	AUX
fnp-3500	380	10	correlated	correlate	VERB
fnp-3500	380	11	with	with	ADP
fnp-3500	380	12	clinical	clinical	ADJ
fnp-3500	380	13	parameters	parameter	NOUN
fnp-3500	380	14	.	.	PUNCT
fnp-3500	380	15	  	  	SPACE
fnp-3500	381	1	poster	poster	NOUN
fnp-3500	381	2	session	session	NOUN
fnp-3500	381	3	iv	iv	NUM
fnp-3500	381	4	–	–	PUNCT
fnp-3500	381	5	neurodegeneration	neurodegeneration	NOUN
fnp-3500	381	6	piv-01	piv-01	NUM
fnp-3500	381	7	free	free	ADJ
fnp-3500	381	8	neuropathol	neuropathol	NOUN
fnp-3500	381	9	2:22:42	2:22:42	NUM
fnp-3500	381	10	the	the	DET
fnp-3500	381	11	interplay	interplay	NOUN
fnp-3500	381	12	between	between	ADP
fnp-3500	381	13	neuroimmune	neuroimmune	NOUN
fnp-3500	381	14	activation	activation	NOUN
fnp-3500	381	15	and	and	CCONJ
fnp-3500	381	16	blood	blood	NOUN
fnp-3500	381	17	brain	brain	NOUN
fnp-3500	381	18	barrier	barrier	NOUN
fnp-3500	381	19	dysfunction	dysfunction	NOUN
fnp-3500	381	20	in	in	ADP
fnp-3500	381	21	alzheimer	alzheimer	PROPN
fnp-3500	381	22	's	's	PART
fnp-3500	381	23	disease	disease	NOUN
fnp-3500	381	24	m.	m.	NOUN
fnp-3500	381	25	armbrust1	armbrust1	PROPN
fnp-3500	381	26	,	,	PUNCT
fnp-3500	381	27	a.	a.	PROPN
fnp-3500	381	28	dominguez	dominguez	PROPN
fnp-3500	381	29	-	-	PUNCT
fnp-3500	381	30	belloso1	belloso1	PROPN
fnp-3500	381	31	,	,	PUNCT
fnp-3500	381	32	r.	r.	PROPN
fnp-3500	381	33	figueiredo2	figueiredo2	PROPN
fnp-3500	381	34	,	,	PUNCT
fnp-3500	381	35	k.	k.	PROPN
fnp-3500	381	36	gneiding1	gneiding1	PROPN
fnp-3500	381	37	,	,	PUNCT
fnp-3500	381	38	s.	s.	PROPN
fnp-3500	381	39	guérit1	guérit1	PROPN
fnp-3500	381	40	,	,	PUNCT
fnp-3500	381	41	s.	s.	PROPN
fnp-3500	381	42	thom1	thom1	PROPN
fnp-3500	381	43	,	,	PUNCT
fnp-3500	381	44	p.	p.	PROPN
fnp-3500	381	45	winter2	winter2	PROPN
fnp-3500	381	46	,	,	PUNCT
fnp-3500	381	47	k.	k.	PROPN
fnp-3500	381	48	h.	h.	PROPN
fnp-3500	381	49	plate1	plate1	PROPN
fnp-3500	381	50	,	,	PUNCT
fnp-3500	381	51	p.	p.	PROPN
fnp-3500	381	52	n.	n.	PROPN
fnp-3500	382	1	harter1	harter1	PROPN
fnp-3500	382	2	,	,	PUNCT
fnp-3500	382	3	k.	k.	PROPN
fnp-3500	383	1	devraj1	devraj1	PROPN
fnp-3500	383	2	,	,	PUNCT
fnp-3500	383	3	s.	s.	PROPN
fnp-3500	383	4	liebner1	liebner1	PROPN
fnp-3500	383	5	1	1	NUM
fnp-3500	383	6	goethe	goethe	PROPN
fnp-3500	383	7	university	university	NOUN
fnp-3500	383	8	hospital	hospital	NOUN
fnp-3500	383	9	,	,	PUNCT
fnp-3500	383	10	neurological	neurological	ADJ
fnp-3500	383	11	institute	institute	NOUN
fnp-3500	383	12	,	,	PUNCT
fnp-3500	383	13	edinger	edinger	PROPN
fnp-3500	383	14	institute	institute	PROPN
fnp-3500	383	15	,	,	PUNCT
fnp-3500	383	16	frankfurt	frankfurt	PROPN
fnp-3500	383	17	a.	a.	NOUN
fnp-3500	383	18	m.	m.	PROPN
fnp-3500	383	19	,	,	PUNCT
fnp-3500	383	20	germany	germany	PROPN
fnp-3500	383	21	2	2	NUM
fnp-3500	383	22	genxpro	genxpro	PROPN
fnp-3500	383	23	gmbh	gmbh	PROPN
fnp-3500	383	24	,	,	PUNCT
fnp-3500	383	25	frankfurt	frankfurt	PROPN
fnp-3500	383	26	a.	a.	NOUN
fnp-3500	383	27	m.	m.	PROPN
fnp-3500	383	28	,	,	PUNCT
fnp-3500	383	29	germany	germany	PROPN
fnp-3500	383	30	introduction	introduction	NOUN
fnp-3500	383	31	:	:	PUNCT
fnp-3500	383	32	alzheimer	alzheimer	PROPN
fnp-3500	383	33	's	's	PART
fnp-3500	383	34	disease	disease	NOUN
fnp-3500	383	35	(	(	PUNCT
fnp-3500	383	36	ad	ad	NOUN
fnp-3500	383	37	)	)	PUNCT
fnp-3500	383	38	is	be	AUX
fnp-3500	383	39	characterized	characterize	VERB
fnp-3500	383	40	by	by	ADP
fnp-3500	383	41	amyloid	amyloid	NOUN
fnp-3500	383	42	-	-	PUNCT
fnp-3500	383	43	β	β	NOUN
fnp-3500	383	44	aggregation	aggregation	NOUN
fnp-3500	383	45	,	,	PUNCT
fnp-3500	383	46	hyperphosphorylated	hyperphosphorylate	VERB
fnp-3500	383	47	tau	tau	PROPN
fnp-3500	383	48	protein	protein	NOUN
fnp-3500	383	49	,	,	PUNCT
fnp-3500	383	50	neuroimmune	neuroimmune	ADJ
fnp-3500	383	51	activation	activation	NOUN
fnp-3500	383	52	,	,	PUNCT
fnp-3500	383	53	neuronal	neuronal	ADJ
fnp-3500	383	54	loss	loss	NOUN
fnp-3500	383	55	and	and	CCONJ
fnp-3500	383	56	blood	blood	NOUN
fnp-3500	383	57	brain	brain	NOUN
fnp-3500	383	58	barrier	barrier	NOUN
fnp-3500	383	59	(	(	PUNCT
fnp-3500	383	60	bbb	bbb	NOUN
fnp-3500	383	61	)	)	PUNCT
fnp-3500	383	62	dysfunction	dysfunction	NOUN
fnp-3500	383	63	.	.	PUNCT
fnp-3500	384	1	the	the	DET
fnp-3500	384	2	contribution	contribution	NOUN
fnp-3500	384	3	of	of	ADP
fnp-3500	384	4	the	the	DET
fnp-3500	384	5	latter	latter	ADJ
fnp-3500	384	6	to	to	ADP
fnp-3500	384	7	disease	disease	NOUN
fnp-3500	384	8	genesis	genesis	NOUN
fnp-3500	384	9	and	and	CCONJ
fnp-3500	384	10	progression	progression	NOUN
fnp-3500	384	11	is	be	AUX
fnp-3500	384	12	poorly	poorly	ADV
fnp-3500	384	13	understood	understand	VERB
fnp-3500	384	14	.	.	PUNCT
fnp-3500	385	1	objectives	objective	NOUN
fnp-3500	385	2	:	:	PUNCT
fnp-3500	385	3	to	to	PART
fnp-3500	385	4	investigate	investigate	VERB
fnp-3500	385	5	wnt	wnt	PROPN
fnp-3500	385	6	/	/	SYM
fnp-3500	385	7	β	β	NOUN
fnp-3500	385	8	-	-	ADJ
fnp-3500	385	9	catenin	catenin	ADJ
fnp-3500	385	10	and	and	CCONJ
fnp-3500	385	11	bbb	bbb	NOUN
fnp-3500	385	12	-	-	PUNCT
fnp-3500	385	13	specific	specific	ADJ
fnp-3500	385	14	alterations	alteration	NOUN
fnp-3500	385	15	in	in	ADP
fnp-3500	385	16	ad	ad	NOUN
fnp-3500	385	17	.	.	PUNCT
fnp-3500	386	1	materials	material	NOUN
fnp-3500	386	2	and	and	CCONJ
fnp-3500	386	3	methods	method	NOUN
fnp-3500	386	4	:	:	PUNCT
fnp-3500	386	5	transgenic	transgenic	NOUN
fnp-3500	386	6	mice	mouse	NOUN
fnp-3500	386	7	harbouring	harbour	VERB
fnp-3500	386	8	triple	triple	ADJ
fnp-3500	386	9	-	-	PUNCT
fnp-3500	386	10	mutated	mutate	VERB
fnp-3500	386	11	(	(	PUNCT
fnp-3500	386	12	swdi	swdi	NOUN
fnp-3500	386	13	)	)	PUNCT
fnp-3500	386	14	human	human	ADJ
fnp-3500	386	15	app	app	NOUN
fnp-3500	386	16	were	be	AUX
fnp-3500	386	17	used	use	VERB
fnp-3500	386	18	for	for	ADP
fnp-3500	386	19	3'-rna	3'-rna	NOUN
fnp-3500	386	20	-	-	PUNCT
fnp-3500	386	21	sequencing	sequence	VERB
fnp-3500	386	22	(	(	PUNCT
fnp-3500	386	23	massive	massive	ADJ
fnp-3500	386	24	analysis	analysis	NOUN
fnp-3500	386	25	of	of	ADP
fnp-3500	386	26	cdna	cdna	PROPN
fnp-3500	386	27	ends	end	VERB
fnp-3500	386	28	:	:	PUNCT
fnp-3500	386	29	mace	mace	PROPN
fnp-3500	386	30	)	)	PUNCT
fnp-3500	386	31	of	of	ADP
fnp-3500	386	32	isolated	isolated	ADJ
fnp-3500	386	33	mouse	mouse	NOUN
fnp-3500	386	34	brain	brain	NOUN
fnp-3500	386	35	microvessels	microvessel	NOUN
fnp-3500	386	36	(	(	PUNCT
fnp-3500	386	37	mbmvs	mbmvs	PROPN
fnp-3500	386	38	)	)	PUNCT
fnp-3500	386	39	and	and	CCONJ
fnp-3500	386	40	of	of	ADP
fnp-3500	386	41	facs	fac	NOUN
fnp-3500	386	42	-	-	PUNCT
fnp-3500	386	43	sorted	sort	VERB
fnp-3500	386	44	cells	cell	NOUN
fnp-3500	386	45	of	of	ADP
fnp-3500	386	46	the	the	DET
fnp-3500	386	47	neurovascular	neurovascular	ADJ
fnp-3500	386	48	unit	unit	NOUN
fnp-3500	386	49	(	(	PUNCT
fnp-3500	386	50	endothelial	endothelial	ADJ
fnp-3500	386	51	cells	cell	NOUN
fnp-3500	386	52	(	(	PUNCT
fnp-3500	386	53	ecs	ecs	PROPN
fnp-3500	386	54	)	)	PUNCT
fnp-3500	386	55	,	,	PUNCT
fnp-3500	386	56	mural	mural	ADJ
fnp-3500	386	57	cells	cell	NOUN
fnp-3500	386	58	,	,	PUNCT
fnp-3500	386	59	astrocytes	astrocyte	NOUN
fnp-3500	386	60	and	and	CCONJ
fnp-3500	386	61	microglia	microglia	ADJ
fnp-3500	386	62	(	(	PUNCT
fnp-3500	386	63	mg	mg	PROPN
fnp-3500	386	64	)	)	PUNCT
fnp-3500	386	65	)	)	PUNCT
fnp-3500	386	66	.	.	PUNCT
fnp-3500	387	1	an	an	DET
fnp-3500	387	2	activation	activation	NOUN
fnp-3500	387	3	of	of	ADP
fnp-3500	387	4	the	the	DET
fnp-3500	387	5	wnt	wnt	PROPN
fnp-3500	387	6	/	/	SYM
fnp-3500	387	7	β	β	NOUN
fnp-3500	387	8	-	-	ADJ
fnp-3500	387	9	catenin	catenin	ADJ
fnp-3500	387	10	pathway	pathway	NOUN
fnp-3500	387	11	in	in	ADP
fnp-3500	387	12	ecs	ecs	PROPN
fnp-3500	387	13	was	be	AUX
fnp-3500	387	14	conducted	conduct	VERB
fnp-3500	387	15	in	in	ADP
fnp-3500	387	16	a	a	DET
fnp-3500	387	17	cre	cre	PROPN
fnp-3500	387	18	-	-	PUNCT
fnp-3500	387	19	loxp	loxp	NOUN
fnp-3500	387	20	-	-	PUNCT
fnp-3500	387	21	based	base	VERB
fnp-3500	387	22	β	β	NOUN
fnp-3500	387	23	-	-	ADJ
fnp-3500	387	24	catenin	catenin	ADJ
fnp-3500	387	25	gain	gain	NOUN
fnp-3500	387	26	-	-	PUNCT
fnp-3500	387	27	of	of	ADP
fnp-3500	387	28	-	-	PUNCT
fnp-3500	387	29	function	function	NOUN
fnp-3500	387	30	(	(	PUNCT
fnp-3500	387	31	gof)-ad	gof)-ad	ADJ
fnp-3500	387	32	mouse	mouse	NOUN
fnp-3500	387	33	model	model	NOUN
fnp-3500	387	34	.	.	PUNCT
fnp-3500	388	1	tracer	tracer	NOUN
fnp-3500	388	2	permeability	permeability	NOUN
fnp-3500	388	3	assays	assay	NOUN
fnp-3500	388	4	,	,	PUNCT
fnp-3500	388	5	immunohistochemistry	immunohistochemistry	NOUN
fnp-3500	388	6	and	and	CCONJ
fnp-3500	388	7	immunofluorescence	immunofluorescence	NOUN
fnp-3500	388	8	analyses	analysis	NOUN
fnp-3500	388	9	as	as	ADV
fnp-3500	388	10	well	well	ADV
fnp-3500	388	11	as	as	ADP
fnp-3500	389	1	behavourial	behavourial	ADJ
fnp-3500	389	2	tests	test	NOUN
fnp-3500	389	3	were	be	AUX
fnp-3500	389	4	performed	perform	VERB
fnp-3500	389	5	in	in	ADP
fnp-3500	389	6	ad	ad	NOUN
fnp-3500	389	7	and	and	CCONJ
fnp-3500	389	8	ad	ad	NOUN
fnp-3500	389	9	-	-	PUNCT
fnp-3500	389	10	gof	gof	NOUN
fnp-3500	389	11	mice	mouse	NOUN
fnp-3500	389	12	.	.	PUNCT
fnp-3500	390	1	results	result	NOUN
fnp-3500	390	2	:	:	PUNCT
fnp-3500	390	3	gene	gene	NOUN
fnp-3500	390	4	ontology	ontology	NOUN
fnp-3500	390	5	analysis	analysis	NOUN
fnp-3500	390	6	revealed	reveal	VERB
fnp-3500	390	7	a	a	DET
fnp-3500	390	8	downregulation	downregulation	NOUN
fnp-3500	390	9	of	of	ADP
fnp-3500	390	10	wnt	wnt	PROPN
fnp-3500	390	11	/	/	SYM
fnp-3500	390	12	β	β	NOUN
fnp-3500	390	13	-	-	ADJ
fnp-3500	390	14	catenin	catenin	NOUN
fnp-3500	390	15	signalling	signalling	NOUN
fnp-3500	390	16	in	in	ADP
fnp-3500	390	17	mbmvs	mbmvs	NOUN
fnp-3500	390	18	and	and	CCONJ
fnp-3500	390	19	facs	fac	NOUN
fnp-3500	390	20	-	-	PUNCT
fnp-3500	390	21	sorted	sort	VERB
fnp-3500	390	22	ecs	ec	NOUN
fnp-3500	390	23	of	of	ADP
fnp-3500	390	24	ad	ad	NOUN
fnp-3500	390	25	mice	mouse	NOUN
fnp-3500	390	26	.	.	PUNCT
fnp-3500	391	1	dkk2	dkk2	PROPN
fnp-3500	391	2	,	,	PUNCT
fnp-3500	391	3	encoding	encode	VERB
fnp-3500	391	4	dickkopf	dickkopf	VERB
fnp-3500	391	5	wnt	wnt	PROPN
fnp-3500	391	6	pathway	pathway	NOUN
fnp-3500	391	7	inhibitor	inhibitor	NOUN
fnp-3500	391	8	2	2	NUM
fnp-3500	391	9	,	,	PUNCT
fnp-3500	391	10	was	be	AUX
fnp-3500	391	11	upregulated	upregulate	VERB
fnp-3500	391	12	in	in	ADP
fnp-3500	391	13	mbmvs	mbmvs	NOUN
fnp-3500	391	14	and	and	CCONJ
fnp-3500	391	15	mg	mg	PROPN
fnp-3500	391	16	.	.	PUNCT
fnp-3500	392	1	in	in	ADP
fnp-3500	392	2	human	human	ADJ
fnp-3500	392	3	ad	ad	NOUN
fnp-3500	392	4	brain	brain	NOUN
fnp-3500	392	5	tissue	tissue	NOUN
fnp-3500	392	6	,	,	PUNCT
fnp-3500	392	7	dkk2	dkk2	PROPN
fnp-3500	392	8	was	be	AUX
fnp-3500	392	9	detected	detect	VERB
fnp-3500	392	10	in	in	ADP
fnp-3500	392	11	mg	mg	PROPN
fnp-3500	392	12	.	.	PUNCT
fnp-3500	393	1	additionally	additionally	ADV
fnp-3500	393	2	,	,	PUNCT
fnp-3500	393	3	an	an	DET
fnp-3500	393	4	increase	increase	NOUN
fnp-3500	393	5	in	in	ADP
fnp-3500	393	6	bbb	bbb	NOUN
fnp-3500	393	7	permeability	permeability	NOUN
fnp-3500	393	8	correlating	correlate	VERB
fnp-3500	393	9	with	with	ADP
fnp-3500	393	10	cognitive	cognitive	ADJ
fnp-3500	393	11	decline	decline	NOUN
fnp-3500	393	12	and	and	CCONJ
fnp-3500	393	13	a	a	DET
fnp-3500	393	14	decrease	decrease	NOUN
fnp-3500	393	15	of	of	ADP
fnp-3500	393	16	vascular	vascular	ADJ
fnp-3500	393	17	lymphoid	lymphoid	NOUN
fnp-3500	393	18	enhancer	enhancer	NOUN
fnp-3500	393	19	-	-	PUNCT
fnp-3500	393	20	binding	bind	VERB
fnp-3500	393	21	factor	factor	NOUN
fnp-3500	393	22	1	1	NUM
fnp-3500	393	23	expression	expression	NOUN
fnp-3500	393	24	,	,	PUNCT
fnp-3500	393	25	a	a	DET
fnp-3500	393	26	target	target	NOUN
fnp-3500	393	27	and	and	CCONJ
fnp-3500	393	28	key	key	ADJ
fnp-3500	393	29	player	player	NOUN
fnp-3500	393	30	in	in	ADP
fnp-3500	393	31	wnt	wnt	PROPN
fnp-3500	393	32	/	/	SYM
fnp-3500	393	33	β	β	NOUN
fnp-3500	393	34	-	-	ADJ
fnp-3500	393	35	catenin	catenin	ADJ
fnp-3500	393	36	signalling	signalling	NOUN
fnp-3500	393	37	,	,	PUNCT
fnp-3500	393	38	was	be	AUX
fnp-3500	393	39	observed	observe	VERB
fnp-3500	393	40	in	in	ADP
fnp-3500	393	41	ad	ad	NOUN
fnp-3500	393	42	mice	mouse	NOUN
fnp-3500	393	43	.	.	PUNCT
fnp-3500	394	1	a	a	DET
fnp-3500	394	2	presymptomatic	presymptomatic	ADJ
fnp-3500	394	3	activation	activation	NOUN
fnp-3500	394	4	of	of	ADP
fnp-3500	394	5	the	the	DET
fnp-3500	394	6	wnt	wnt	PROPN
fnp-3500	394	7	/	/	SYM
fnp-3500	394	8	β	β	NOUN
fnp-3500	394	9	-	-	ADJ
fnp-3500	394	10	catenin	catenin	ADJ
fnp-3500	394	11	pathway	pathway	NOUN
fnp-3500	394	12	in	in	ADP
fnp-3500	394	13	ecs	ecs	PROPN
fnp-3500	394	14	of	of	ADP
fnp-3500	394	15	gof	gof	ADJ
fnp-3500	394	16	-	-	PUNCT
fnp-3500	394	17	ad	ad	NOUN
fnp-3500	394	18	mice	mouse	NOUN
fnp-3500	394	19	partially	partially	ADV
fnp-3500	394	20	prevented	prevent	VERB
fnp-3500	394	21	cognitive	cognitive	ADJ
fnp-3500	394	22	decline	decline	NOUN
fnp-3500	394	23	.	.	PUNCT
fnp-3500	395	1	conclusion	conclusion	NOUN
fnp-3500	395	2	:	:	PUNCT
fnp-3500	395	3	dkk2	dkk2	PROPN
fnp-3500	395	4	upregulation	upregulation	NOUN
fnp-3500	395	5	in	in	ADP
fnp-3500	395	6	microvessel	microvessel	NOUN
fnp-3500	395	7	-	-	PUNCT
fnp-3500	395	8	associated	associate	VERB
fnp-3500	395	9	mg	mg	PROPN
fnp-3500	395	10	could	could	AUX
fnp-3500	395	11	contribute	contribute	VERB
fnp-3500	395	12	to	to	ADP
fnp-3500	395	13	the	the	DET
fnp-3500	395	14	wnt	wnt	NOUN
fnp-3500	395	15	/	/	SYM
fnp-3500	395	16	β	β	NOUN
fnp-3500	395	17	-	-	ADJ
fnp-3500	395	18	catenin	catenin	ADJ
fnp-3500	395	19	pathway	pathway	NOUN
fnp-3500	395	20	repression	repression	NOUN
fnp-3500	395	21	observed	observe	VERB
fnp-3500	395	22	at	at	ADP
fnp-3500	395	23	the	the	DET
fnp-3500	395	24	bbb	bbb	NOUN
fnp-3500	395	25	in	in	ADP
fnp-3500	395	26	ad	ad	NOUN
fnp-3500	395	27	.	.	PUNCT
fnp-3500	396	1	together	together	ADV
fnp-3500	396	2	with	with	ADP
fnp-3500	396	3	the	the	DET
fnp-3500	396	4	prevention	prevention	NOUN
fnp-3500	396	5	of	of	ADP
fnp-3500	396	6	cognitive	cognitive	ADJ
fnp-3500	396	7	decline	decline	NOUN
fnp-3500	396	8	after	after	ADP
fnp-3500	396	9	presymptomatic	presymptomatic	ADJ
fnp-3500	396	10	activation	activation	NOUN
fnp-3500	396	11	of	of	ADP
fnp-3500	396	12	the	the	DET
fnp-3500	396	13	wnt	wnt	PROPN
fnp-3500	396	14	/	/	SYM
fnp-3500	396	15	β	β	NOUN
fnp-3500	396	16	-	-	ADJ
fnp-3500	396	17	catenin	catenin	ADJ
fnp-3500	396	18	pathway	pathway	NOUN
fnp-3500	396	19	,	,	PUNCT
fnp-3500	396	20	our	our	PRON
fnp-3500	396	21	findings	finding	NOUN
fnp-3500	396	22	indicate	indicate	VERB
fnp-3500	396	23	a	a	DET
fnp-3500	396	24	potential	potential	ADJ
fnp-3500	396	25	link	link	NOUN
fnp-3500	396	26	between	between	ADP
fnp-3500	396	27	neuroimmune	neuroimmune	NOUN
fnp-3500	396	28	activation	activation	NOUN
fnp-3500	396	29	and	and	CCONJ
fnp-3500	396	30	bbb	bbb	NUM
fnp-3500	396	31	dysfunction	dysfunction	NOUN
fnp-3500	396	32	and	and	CCONJ
fnp-3500	396	33	propose	propose	VERB
fnp-3500	396	34	the	the	DET
fnp-3500	396	35	wnt	wnt	NOUN
fnp-3500	396	36	/	/	SYM
fnp-3500	396	37	β	β	NOUN
fnp-3500	396	38	-	-	ADJ
fnp-3500	396	39	catenin	catenin	ADJ
fnp-3500	396	40	pathway	pathway	NOUN
fnp-3500	396	41	as	as	ADP
fnp-3500	396	42	a	a	DET
fnp-3500	396	43	potential	potential	ADJ
fnp-3500	396	44	therapeutic	therapeutic	ADJ
fnp-3500	396	45	target	target	NOUN
fnp-3500	396	46	.	.	PUNCT
fnp-3500	396	47	  	  	SPACE
fnp-3500	397	1	piv-02	piv-02	ADP
fnp-3500	397	2	a	a	DET
fnp-3500	397	3	deep	deep	ADJ
fnp-3500	397	4	learning	learning	NOUN
fnp-3500	397	5	approach	approach	NOUN
fnp-3500	397	6	for	for	ADP
fnp-3500	397	7	monitoring	monitor	VERB
fnp-3500	397	8	parietal	parietal	ADJ
fnp-3500	397	9	-	-	PUNCT
fnp-3500	397	10	dominant	dominant	ADJ
fnp-3500	397	11	alzheimer	alzheimer	PROPN
fnp-3500	397	12	's	's	PART
fnp-3500	397	13	disease	disease	NOUN
fnp-3500	397	14	in	in	ADP
fnp-3500	397	15	world	world	NOUN
fnp-3500	397	16	trade	trade	NOUN
fnp-3500	397	17	center	center	NOUN
fnp-3500	397	18	responders	responder	NOUN
fnp-3500	397	19	at	at	ADP
fnp-3500	397	20	midlife	midlife	NOUN
fnp-3500	397	21	not	not	PART
fnp-3500	397	22	available	available	ADJ
fnp-3500	397	23	for	for	ADP
fnp-3500	397	24	publication	publication	NOUN
fnp-3500	397	25	  	  	SPACE
fnp-3500	397	26	piv-03	piv-03	PROPN
fnp-3500	397	27	free	free	ADJ
fnp-3500	397	28	neuropathol	neuropathol	NOUN
fnp-3500	397	29	2:22:44	2:22:44	NUM
fnp-3500	397	30	amyloid	amyloid	NOUN
fnp-3500	397	31	-	-	PUNCT
fnp-3500	397	32	β	β	NOUN
fnp-3500	397	33	dimers	dimer	NOUN
fnp-3500	397	34	(	(	PUNCT
fnp-3500	397	35	aβ	aβ	NOUN
fnp-3500	397	36	-	-	PUNCT
fnp-3500	397	37	s8c	s8c	NOUN
fnp-3500	397	38	)	)	PUNCT
fnp-3500	397	39	are	be	AUX
fnp-3500	397	40	antiprions	antiprion	NOUN
fnp-3500	397	41	inhibiting	inhibit	VERB
fnp-3500	397	42	seeded	seeded	ADJ
fnp-3500	397	43	nucleation	nucleation	NOUN
fnp-3500	397	44	in	in	ADP
fnp-3500	397	45	vivo	vivo	PROPN
fnp-3500	397	46	e.	e.	PROPN
fnp-3500	397	47	van	van	PROPN
fnp-3500	397	48	gerresheim1	gerresheim1	PROPN
fnp-3500	397	49	,	,	PUNCT
fnp-3500	397	50	a.	a.	PROPN
fnp-3500	397	51	müller	müller	PROPN
fnp-3500	397	52	-	-	PUNCT
fnp-3500	397	53	schiffmann1	schiffmann1	PROPN
fnp-3500	397	54	,	,	PUNCT
fnp-3500	397	55	s.	s.	PROPN
fnp-3500	397	56	schäble2	schäble2	PROPN
fnp-3500	397	57	,	,	PUNCT
fnp-3500	397	58	c.	c.	PROPN
fnp-3500	397	59	korth1	korth1	PROPN
fnp-3500	397	60	1	1	NUM
fnp-3500	397	61	heinrich	heinrich	PROPN
fnp-3500	397	62	-	-	PUNCT
fnp-3500	397	63	heine	heine	PROPN
fnp-3500	397	64	university	university	PROPN
fnp-3500	397	65	düsseldorf	düsseldorf	PROPN
fnp-3500	397	66	,	,	PUNCT
fnp-3500	397	67	neuropathology	neuropathology	NOUN
fnp-3500	397	68	,	,	PUNCT
fnp-3500	397	69	düsseldorf	düsseldorf	PROPN
fnp-3500	397	70	,	,	PUNCT
fnp-3500	397	71	germany	germany	PROPN
fnp-3500	397	72	2	2	NUM
fnp-3500	397	73	heinrich	heinrich	PROPN
fnp-3500	397	74	-	-	PUNCT
fnp-3500	397	75	heine	heine	PROPN
fnp-3500	397	76	university	university	PROPN
fnp-3500	397	77	düsseldorf	düsseldorf	PROPN
fnp-3500	397	78	,	,	PUNCT
fnp-3500	397	79	experimental	experimental	ADJ
fnp-3500	397	80	psychology	psychology	NOUN
fnp-3500	397	81	,	,	PUNCT
fnp-3500	397	82	düsseldorf	düsseldorf	PROPN
fnp-3500	397	83	,	,	PUNCT
fnp-3500	397	84	germany	germany	PROPN
fnp-3500	397	85	introduction	introduction	NOUN
fnp-3500	397	86	:	:	PUNCT
fnp-3500	397	87	alzheimer"s	alzheimer"s	NUM
fnp-3500	397	88	disease	disease	NOUN
fnp-3500	397	89	(	(	PUNCT
fnp-3500	397	90	ad	ad	NOUN
fnp-3500	397	91	)	)	PUNCT
fnp-3500	397	92	is	be	AUX
fnp-3500	397	93	a	a	DET
fnp-3500	397	94	neurologic	neurologic	ADJ
fnp-3500	397	95	disorder	disorder	NOUN
fnp-3500	397	96	,	,	PUNCT
fnp-3500	397	97	were	be	AUX
fnp-3500	397	98	amyloid	amyloid	NOUN
fnp-3500	397	99	-	-	PUNCT
fnp-3500	397	100	beta	beta	NOUN
fnp-3500	397	101	(	(	PUNCT
fnp-3500	397	102	aβ	aβ	NOUN
fnp-3500	397	103	)	)	PUNCT
fnp-3500	397	104	aggregation	aggregation	NOUN
fnp-3500	397	105	causes	cause	VERB
fnp-3500	397	106	massive	massive	ADJ
fnp-3500	397	107	neuronal	neuronal	ADJ
fnp-3500	397	108	death	death	NOUN
fnp-3500	397	109	.	.	PUNCT
fnp-3500	398	1	aβ	aβ	DET
fnp-3500	398	2	expansion	expansion	NOUN
fnp-3500	398	3	can	can	AUX
fnp-3500	398	4	follow	follow	VERB
fnp-3500	398	5	prion	prion	NOUN
fnp-3500	398	6	-	-	PUNCT
fnp-3500	398	7	like	like	ADJ
fnp-3500	398	8	replication	replication	NOUN
fnp-3500	398	9	from	from	ADP
fnp-3500	398	10	aβ	aβ	DET
fnp-3500	398	11	seeds	seed	NOUN
fnp-3500	398	12	.	.	PUNCT
fnp-3500	399	1	with	with	ADP
fnp-3500	399	2	the	the	DET
fnp-3500	399	3	current	current	ADJ
fnp-3500	399	4	animal	animal	NOUN
fnp-3500	399	5	models	model	NOUN
fnp-3500	399	6	,	,	PUNCT
fnp-3500	399	7	based	base	VERB
fnp-3500	399	8	on	on	ADP
fnp-3500	399	9	the	the	DET
fnp-3500	399	10	overexpression	overexpression	NOUN
fnp-3500	399	11	of	of	ADP
fnp-3500	399	12	aβ	aβ	NOUN
fnp-3500	399	13	,	,	PUNCT
fnp-3500	399	14	used	use	VERB
fnp-3500	399	15	to	to	PART
fnp-3500	399	16	study	study	VERB
fnp-3500	399	17	the	the	DET
fnp-3500	399	18	aβ	aβ	NOUN
fnp-3500	399	19	cascade	cascade	NOUN
fnp-3500	399	20	and	and	CCONJ
fnp-3500	399	21	prion	prion	NOUN
fnp-3500	399	22	-	-	PUNCT
fnp-3500	399	23	like	like	ADJ
fnp-3500	399	24	expansion	expansion	NOUN
fnp-3500	399	25	,	,	PUNCT
fnp-3500	399	26	it	it	PRON
fnp-3500	399	27	is	be	AUX
fnp-3500	399	28	impossible	impossible	ADJ
fnp-3500	399	29	to	to	PART
fnp-3500	399	30	distinguish	distinguish	VERB
fnp-3500	399	31	between	between	ADP
fnp-3500	399	32	exogenous	exogenous	ADJ
fnp-3500	399	33	de	de	X
fnp-3500	399	34	novo	novo	NOUN
fnp-3500	399	35	seeding	seed	VERB
fnp-3500	399	36	and	and	CCONJ
fnp-3500	399	37	accelerated	accelerate	VERB
fnp-3500	399	38	spontaneous	spontaneous	ADJ
fnp-3500	399	39	plaque	plaque	NOUN
fnp-3500	399	40	development	development	NOUN
fnp-3500	399	41	.	.	PUNCT
fnp-3500	400	1	so	so	ADV
fnp-3500	400	2	far	far	ADV
fnp-3500	400	3	,	,	PUNCT
fnp-3500	400	4	seeding	seed	VERB
fnp-3500	400	5	of	of	ADP
fnp-3500	400	6	aβ	aβ	NOUN
fnp-3500	400	7	in	in	ADP
fnp-3500	400	8	wild	wild	ADJ
fnp-3500	400	9	type	type	NOUN
fnp-3500	400	10	animals	animal	NOUN
fnp-3500	400	11	has	have	AUX
fnp-3500	400	12	not	not	PART
fnp-3500	400	13	been	be	AUX
fnp-3500	400	14	successful	successful	ADJ
fnp-3500	400	15	.	.	PUNCT
fnp-3500	401	1	objectives	objective	NOUN
fnp-3500	401	2	:	:	PUNCT
fnp-3500	401	3	here	here	ADV
fnp-3500	401	4	we	we	PRON
fnp-3500	401	5	studied	study	VERB
fnp-3500	401	6	the	the	DET
fnp-3500	401	7	effects	effect	NOUN
fnp-3500	401	8	of	of	ADP
fnp-3500	401	9	aβ	aβ	NOUN
fnp-3500	401	10	-	-	PUNCT
fnp-3500	401	11	s8c	s8c	NOUN
fnp-3500	401	12	dimers	dimer	NOUN
fnp-3500	401	13	on	on	ADP
fnp-3500	401	14	aβ	aβ	PRON
fnp-3500	401	15	prion	prion	NOUN
fnp-3500	401	16	spreading	spread	VERB
fnp-3500	401	17	and	and	CCONJ
fnp-3500	401	18	induced	induce	VERB
fnp-3500	401	19	behavioral	behavioral	ADJ
fnp-3500	401	20	changes	change	NOUN
fnp-3500	401	21	.	.	PUNCT
fnp-3500	402	1	materials	material	NOUN
fnp-3500	402	2	and	and	CCONJ
fnp-3500	402	3	methods	method	NOUN
fnp-3500	402	4	:	:	PUNCT
fnp-3500	402	5	tgdimer	tgdimer	NOUN
fnp-3500	402	6	mice	mouse	NOUN
fnp-3500	402	7	,	,	PUNCT
fnp-3500	402	8	expressing	express	VERB
fnp-3500	402	9	human	human	ADJ
fnp-3500	402	10	app751	app751	PROPN
fnp-3500	402	11	(	(	PUNCT
fnp-3500	402	12	swe	swe	NOUN
fnp-3500	402	13	,	,	PUNCT
fnp-3500	402	14	k670	k670	PROPN
fnp-3500	402	15	n/	n/	ADV
fnp-3500	402	16	m671l	m671l	PROPN
fnp-3500	402	17	,	,	PUNCT
fnp-3500	402	18	s679c	s679c	PROPN
fnp-3500	402	19	)	)	PUNCT
fnp-3500	402	20	,	,	PUNCT
fnp-3500	402	21	only	only	ADV
fnp-3500	402	22	develop	develop	VERB
fnp-3500	402	23	aβ	aβ	NUM
fnp-3500	402	24	-	-	PUNCT
fnp-3500	402	25	s8c	s8c	NOUN
fnp-3500	402	26	dimers	dimer	NOUN
fnp-3500	402	27	and	and	CCONJ
fnp-3500	402	28	do	do	AUX
fnp-3500	402	29	not	not	PART
fnp-3500	402	30	develop	develop	VERB
fnp-3500	402	31	aβ	aβ	ADP
fnp-3500	402	32	plaques	plaque	NOUN
fnp-3500	402	33	,	,	PUNCT
fnp-3500	402	34	but	but	CCONJ
fnp-3500	402	35	do	do	AUX
fnp-3500	402	36	associate	associate	VERB
fnp-3500	402	37	to	to	ADP
fnp-3500	402	38	existing	exist	VERB
fnp-3500	402	39	plaques	plaque	NOUN
fnp-3500	402	40	,	,	PUNCT
fnp-3500	402	41	were	be	AUX
fnp-3500	402	42	crossed	cross	VERB
fnp-3500	402	43	with	with	ADP
fnp-3500	402	44	gfap	gfap	ADJ
fnp-3500	402	45	-	-	PUNCT
fnp-3500	402	46	luc	luc	NOUN
fnp-3500	402	47	mice	mouse	NOUN
fnp-3500	402	48	,	,	PUNCT
fnp-3500	402	49	enabling	enable	VERB
fnp-3500	402	50	bioluminescence	bioluminescence	NOUN
fnp-3500	402	51	(	(	PUNCT
fnp-3500	402	52	bli	bli	NOUN
fnp-3500	402	53	)	)	PUNCT
fnp-3500	402	54	monitoring	monitoring	NOUN
fnp-3500	402	55	of	of	ADP
fnp-3500	402	56	aβ	aβ	DET
fnp-3500	402	57	aggregation	aggregation	NOUN
fnp-3500	402	58	-	-	PUNCT
fnp-3500	402	59	associated	associate	VERB
fnp-3500	402	60	astrogliosis	astrogliosis	NOUN
fnp-3500	402	61	.	.	PUNCT
fnp-3500	403	1	mice	mouse	NOUN
fnp-3500	403	2	were	be	AUX
fnp-3500	403	3	intra	intra	ADJ
fnp-3500	403	4	-	-	ADJ
fnp-3500	403	5	hippocampal	hippocampal	ADJ
fnp-3500	403	6	inoculated	inoculate	VERB
fnp-3500	403	7	with	with	ADP
fnp-3500	403	8	aβ	aβ	ADP
fnp-3500	403	9	aggregates	aggregate	NOUN
fnp-3500	403	10	.	.	PUNCT
fnp-3500	404	1	wild	wild	ADJ
fnp-3500	404	2	type	type	NOUN
fnp-3500	404	3	and	and	CCONJ
fnp-3500	404	4	app23	app23	PROPN
fnp-3500	404	5	mice	mouse	NOUN
fnp-3500	404	6	,	,	PUNCT
fnp-3500	404	7	aβ	aβ	PRON
fnp-3500	404	8	aggregate	aggregate	NOUN
fnp-3500	404	9	inoculated	inoculate	VERB
fnp-3500	404	10	,	,	PUNCT
fnp-3500	404	11	were	be	AUX
fnp-3500	404	12	used	use	VERB
fnp-3500	404	13	as	as	ADP
fnp-3500	404	14	controls	control	NOUN
fnp-3500	404	15	.	.	PUNCT
fnp-3500	405	1	cognition	cognition	NOUN
fnp-3500	405	2	was	be	AUX
fnp-3500	405	3	probed	probe	VERB
fnp-3500	405	4	in	in	ADP
fnp-3500	405	5	the	the	DET
fnp-3500	405	6	observer	observer	NOUN
fnp-3500	405	7	-	-	PUNCT
fnp-3500	405	8	free	free	ADJ
fnp-3500	405	9	paradigm	paradigm	NOUN
fnp-3500	405	10	,	,	PUNCT
fnp-3500	405	11	the	the	DET
fnp-3500	405	12	cognitionwall	cognitionwall	NOUN
fnp-3500	405	13	,	,	PUNCT
fnp-3500	405	14	for	for	ADP
fnp-3500	405	15	reward	reward	NOUN
fnp-3500	405	16	-	-	PUNCT
fnp-3500	405	17	dependent	dependent	ADJ
fnp-3500	405	18	learning	learning	NOUN
fnp-3500	405	19	and	and	CCONJ
fnp-3500	405	20	burrowing	burrowing	NOUN
fnp-3500	405	21	as	as	ADP
fnp-3500	405	22	species	species	NOUN
fnp-3500	405	23	-	-	PUNCT
fnp-3500	405	24	specific	specific	ADJ
fnp-3500	405	25	behavior	behavior	NOUN
fnp-3500	405	26	.	.	PUNCT
fnp-3500	406	1	results	result	NOUN
fnp-3500	406	2	:	:	PUNCT
fnp-3500	406	3	we	we	PRON
fnp-3500	406	4	observed	observe	VERB
fnp-3500	406	5	no	no	DET
fnp-3500	406	6	aβ	aβ	PRON
fnp-3500	406	7	aggregation	aggregation	NOUN
fnp-3500	406	8	-	-	PUNCT
fnp-3500	406	9	associated	associate	VERB
fnp-3500	406	10	astrogliosis	astrogliosis	NOUN
fnp-3500	406	11	or	or	CCONJ
fnp-3500	406	12	impaired	impaired	ADJ
fnp-3500	406	13	cognition	cognition	NOUN
fnp-3500	406	14	in	in	ADP
fnp-3500	406	15	the	the	DET
fnp-3500	406	16	tgdimer	tgdimer	NOUN
fnp-3500	406	17	mice	mouse	NOUN
fnp-3500	406	18	inoculated	inoculate	VERB
fnp-3500	406	19	with	with	ADP
fnp-3500	406	20	aβ	aβ	NOUN
fnp-3500	406	21	aggregate	aggregate	ADJ
fnp-3500	406	22	.	.	PUNCT
fnp-3500	407	1	for	for	ADP
fnp-3500	407	2	the	the	DET
fnp-3500	407	3	positive	positive	ADJ
fnp-3500	407	4	control	control	NOUN
fnp-3500	407	5	,	,	PUNCT
fnp-3500	407	6	the	the	DET
fnp-3500	407	7	app23	app23	PROPN
fnp-3500	407	8	mice	mouse	NOUN
fnp-3500	407	9	,	,	PUNCT
fnp-3500	407	10	an	an	DET
fnp-3500	407	11	increase	increase	NOUN
fnp-3500	407	12	in	in	ADP
fnp-3500	407	13	bli	bli	PROPN
fnp-3500	407	14	signal	signal	PROPN
fnp-3500	407	15	started	start	VERB
fnp-3500	407	16	at	at	ADP
fnp-3500	407	17	11	11	NUM
fnp-3500	407	18	months	month	NOUN
fnp-3500	407	19	of	of	ADP
fnp-3500	407	20	age	age	NOUN
fnp-3500	407	21	and	and	CCONJ
fnp-3500	407	22	at	at	ADP
fnp-3500	407	23	18	18	NUM
fnp-3500	407	24	months	month	NOUN
fnp-3500	407	25	of	of	ADP
fnp-3500	407	26	age	age	NOUN
fnp-3500	407	27	,	,	PUNCT
fnp-3500	407	28	app23	app23	PROPN
fnp-3500	407	29	mice	mouse	NOUN
fnp-3500	407	30	showed	show	VERB
fnp-3500	407	31	impaired	impaired	ADJ
fnp-3500	407	32	discrimination	discrimination	NOUN
fnp-3500	407	33	learning	learning	NOUN
fnp-3500	407	34	in	in	ADP
fnp-3500	407	35	the	the	DET
fnp-3500	407	36	cognitionwall	cognitionwall	NOUN
fnp-3500	407	37	.	.	PUNCT
fnp-3500	408	1	conclusions	conclusion	NOUN
fnp-3500	408	2	:	:	PUNCT
fnp-3500	408	3	aβ	aβ	NUM
fnp-3500	408	4	-	-	PUNCT
fnp-3500	408	5	s8c	s8c	NOUN
fnp-3500	408	6	dimers	dimer	NOUN
fnp-3500	408	7	inhibit	inhibit	VERB
fnp-3500	408	8	aβ	aβ	PRON
fnp-3500	408	9	aggregate	aggregate	ADJ
fnp-3500	408	10	spreading	spread	VERB
fnp-3500	408	11	and	and	CCONJ
fnp-3500	408	12	are	be	AUX
fnp-3500	408	13	thus	thus	ADV
fnp-3500	408	14	anti	anti	NOUN
fnp-3500	408	15	-	-	NOUN
fnp-3500	408	16	prions	prion	NOUN
fnp-3500	408	17	.	.	PUNCT
fnp-3500	409	1	they	they	PRON
fnp-3500	409	2	may	may	AUX
fnp-3500	409	3	have	have	VERB
fnp-3500	409	4	a	a	DET
fnp-3500	409	5	regulatory	regulatory	ADJ
fnp-3500	409	6	role	role	NOUN
fnp-3500	409	7	for	for	ADP
fnp-3500	409	8	aggregate	aggregate	ADJ
fnp-3500	409	9	spreading	spreading	NOUN
fnp-3500	409	10	suggesting	suggest	VERB
fnp-3500	409	11	that	that	SCONJ
fnp-3500	409	12	aβ	aβ	NOUN
fnp-3500	409	13	prion	prion	NOUN
fnp-3500	409	14	effects	effect	NOUN
fnp-3500	409	15	are	be	AUX
fnp-3500	409	16	actively	actively	ADV
fnp-3500	409	17	regulated	regulate	VERB
fnp-3500	409	18	rather	rather	ADV
fnp-3500	409	19	than	than	ADP
fnp-3500	409	20	a	a	DET
fnp-3500	409	21	passive	passive	ADJ
fnp-3500	409	22	process	process	NOUN
fnp-3500	409	23	.	.	PUNCT
fnp-3500	410	1	the	the	DET
fnp-3500	410	2	difference	difference	NOUN
fnp-3500	410	3	in	in	ADP
fnp-3500	410	4	time	time	NOUN
fnp-3500	410	5	of	of	ADP
fnp-3500	410	6	start	start	NOUN
fnp-3500	410	7	of	of	ADP
fnp-3500	410	8	aβ	aβ	NOUN
fnp-3500	410	9	aggregate	aggregate	ADJ
fnp-3500	410	10	spreading	spread	VERB
fnp-3500	410	11	and	and	CCONJ
fnp-3500	410	12	impaired	impaired	ADJ
fnp-3500	410	13	discrimination	discrimination	NOUN
fnp-3500	410	14	learning	learning	NOUN
fnp-3500	410	15	in	in	ADP
fnp-3500	410	16	app23	app23	PROPN
fnp-3500	410	17	mice	mouse	NOUN
fnp-3500	410	18	suggests	suggest	VERB
fnp-3500	410	19	that	that	SCONJ
fnp-3500	410	20	behavioral	behavioral	ADJ
fnp-3500	410	21	consequences	consequence	NOUN
fnp-3500	410	22	are	be	AUX
fnp-3500	410	23	disparate	disparate	ADJ
fnp-3500	410	24	from	from	ADP
fnp-3500	410	25	initial	initial	ADJ
fnp-3500	410	26	neuropathological	neuropathological	ADJ
fnp-3500	410	27	signs	sign	NOUN
fnp-3500	410	28	.	.	PUNCT
fnp-3500	410	29	  	  	SPACE
fnp-3500	411	1	piv-04	piv-04	ADV
fnp-3500	411	2	free	free	ADJ
fnp-3500	411	3	neuropathol	neuropathol	NOUN
fnp-3500	411	4	2:22:45	2:22:45	NUM
fnp-3500	411	5	a	a	DET
fnp-3500	411	6	decline	decline	NOUN
fnp-3500	411	7	in	in	ADP
fnp-3500	411	8	peroxisomal	peroxisomal	ADJ
fnp-3500	411	9	numerical	numerical	PROPN
fnp-3500	411	10	abundance	abundance	PROPN
fnp-3500	411	11	occurs	occur	VERB
fnp-3500	411	12	late	late	ADV
fnp-3500	411	13	during	during	ADP
fnp-3500	411	14	alzheimer´s	alzheimer´s	NOUN
fnp-3500	411	15	disease	disease	NOUN
fnp-3500	411	16	progression	progression	NOUN
fnp-3500	411	17	and	and	CCONJ
fnp-3500	411	18	is	be	AUX
fnp-3500	411	19	particulary	particulary	ADJ
fnp-3500	411	20	found	find	VERB
fnp-3500	411	21	in	in	ADP
fnp-3500	411	22	the	the	DET
fnp-3500	411	23	hippocampus	hippocampus	PROPN
fnp-3500	411	24	e.	e.	PROPN
fnp-3500	411	25	semikasev1	semikasev1	PROPN
fnp-3500	411	26	,	,	PUNCT
fnp-3500	411	27	b.	b.	PROPN
fnp-3500	411	28	ahlemeyer1	ahlemeyer1	PROPN
fnp-3500	411	29	,	,	PUNCT
fnp-3500	411	30	t.	t.	PROPN
fnp-3500	411	31	acker2	acker2	PROPN
fnp-3500	411	32	,	,	PUNCT
fnp-3500	411	33	a.	a.	NOUN
fnp-3500	411	34	schänzer2	schänzer2	PROPN
fnp-3500	411	35	,	,	PUNCT
fnp-3500	411	36	e.	e.	PROPN
fnp-3500	411	37	baumgart	baumgart	PROPN
fnp-3500	411	38	-	-	PUNCT
fnp-3500	411	39	vogt1	vogt1	NOUN
fnp-3500	411	40	1	1	NUM
fnp-3500	411	41	institute	institute	NOUN
fnp-3500	411	42	of	of	ADP
fnp-3500	411	43	anatomy	anatomy	NOUN
fnp-3500	411	44	and	and	CCONJ
fnp-3500	411	45	cell	cell	NOUN
fnp-3500	411	46	biology	biology	NOUN
fnp-3500	411	47	,	,	PUNCT
fnp-3500	411	48	medical	medical	ADJ
fnp-3500	411	49	cell	cell	NOUN
fnp-3500	411	50	biology	biology	NOUN
fnp-3500	411	51	,	,	PUNCT
fnp-3500	411	52	jl	jl	PROPN
fnp-3500	411	53	university	university	NOUN
fnp-3500	411	54	,	,	PUNCT
fnp-3500	411	55	gießen	gießen	PROPN
fnp-3500	411	56	,	,	PUNCT
fnp-3500	411	57	germany	germany	PROPN
fnp-3500	411	58	2	2	NUM
fnp-3500	411	59	institute	institute	PROPN
fnp-3500	411	60	of	of	ADP
fnp-3500	411	61	neuropathology	neuropathology	NOUN
fnp-3500	411	62	,	,	PUNCT
fnp-3500	411	63	jl	jl	PROPN
fnp-3500	411	64	university	university	NOUN
fnp-3500	411	65	,	,	PUNCT
fnp-3500	411	66	gießen	gießen	PROPN
fnp-3500	411	67	,	,	PUNCT
fnp-3500	411	68	germany	germany	PROPN
fnp-3500	411	69	peroxisomal	peroxisomal	ADJ
fnp-3500	411	70	biogenesis	biogenesis	NOUN
fnp-3500	411	71	disorders	disorder	NOUN
fnp-3500	411	72	are	be	AUX
fnp-3500	411	73	inherited	inherit	VERB
fnp-3500	411	74	metabolic	metabolic	NOUN
fnp-3500	411	75	diseases	disease	NOUN
fnp-3500	411	76	caused	cause	VERB
fnp-3500	411	77	by	by	ADP
fnp-3500	411	78	mutations	mutation	NOUN
fnp-3500	411	79	in	in	ADP
fnp-3500	411	80	the	the	DET
fnp-3500	411	81	pex	pex	PROPN
fnp-3500	411	82	genes	gene	NOUN
fnp-3500	411	83	.	.	PUNCT
fnp-3500	412	1	in	in	ADP
fnp-3500	412	2	severe	severe	ADJ
fnp-3500	412	3	forms	form	NOUN
fnp-3500	412	4	,	,	PUNCT
fnp-3500	412	5	patients	patient	NOUN
fnp-3500	412	6	have	have	VERB
fnp-3500	412	7	profound	profound	ADJ
fnp-3500	412	8	defects	defect	NOUN
fnp-3500	412	9	in	in	ADP
fnp-3500	412	10	the	the	DET
fnp-3500	412	11	brain	brain	NOUN
fnp-3500	412	12	demonstrating	demonstrate	VERB
fnp-3500	412	13	the	the	DET
fnp-3500	412	14	importance	importance	NOUN
fnp-3500	412	15	of	of	ADP
fnp-3500	412	16	this	this	DET
fnp-3500	412	17	organelle	organelle	NOUN
fnp-3500	412	18	for	for	ADP
fnp-3500	412	19	neuronal	neuronal	ADJ
fnp-3500	412	20	survival	survival	NOUN
fnp-3500	412	21	and	and	CCONJ
fnp-3500	412	22	function	function	NOUN
fnp-3500	412	23	.	.	PUNCT
fnp-3500	413	1	additionally	additionally	ADV
fnp-3500	413	2	,	,	PUNCT
fnp-3500	413	3	dysfunction	dysfunction	NOUN
fnp-3500	413	4	of	of	ADP
fnp-3500	413	5	the	the	DET
fnp-3500	413	6	peroxisomal	peroxisomal	ADJ
fnp-3500	413	7	metabolism	metabolism	NOUN
fnp-3500	413	8	,	,	PUNCT
fnp-3500	413	9	e.g.	e.g.	ADV
fnp-3500	413	10	plasmalogen	plasmalogen	NOUN
fnp-3500	413	11	synthesis	synthesis	NOUN
fnp-3500	413	12	or	or	CCONJ
fnp-3500	413	13	the	the	DET
fnp-3500	413	14	degradation	degradation	NOUN
fnp-3500	413	15	of	of	ADP
fnp-3500	413	16	very	very	ADV
fnp-3500	413	17	long	long	ADV
fnp-3500	413	18	-	-	PUNCT
fnp-3500	413	19	chained	chain	VERB
fnp-3500	413	20	fatty	fatty	NOUN
fnp-3500	413	21	acids	acid	NOUN
fnp-3500	413	22	,	,	PUNCT
fnp-3500	413	23	has	have	VERB
fnp-3500	413	24	to	to	PART
fnp-3500	413	25	been	be	AUX
fnp-3500	413	26	linked	link	VERB
fnp-3500	413	27	to	to	ADP
fnp-3500	413	28	neurodegenerative	neurodegenerative	ADJ
fnp-3500	413	29	diseases	disease	NOUN
fnp-3500	413	30	such	such	ADJ
fnp-3500	413	31	as	as	ADP
fnp-3500	413	32	alzheimer´s	alzheimer´s	NOUN
fnp-3500	413	33	disease	disease	NOUN
fnp-3500	413	34	(	(	PUNCT
fnp-3500	413	35	ad	ad	NOUN
fnp-3500	413	36	)	)	PUNCT
fnp-3500	413	37	.	.	PUNCT
fnp-3500	414	1	to	to	PART
fnp-3500	414	2	study	study	VERB
fnp-3500	414	3	the	the	DET
fnp-3500	414	4	role	role	NOUN
fnp-3500	414	5	of	of	ADP
fnp-3500	414	6	peroxisomes	peroxisome	NOUN
fnp-3500	414	7	in	in	ADP
fnp-3500	414	8	ad	ad	NOUN
fnp-3500	414	9	,	,	PUNCT
fnp-3500	414	10	we	we	PRON
fnp-3500	414	11	analyzed	analyze	VERB
fnp-3500	414	12	the	the	DET
fnp-3500	414	13	density	density	NOUN
fnp-3500	414	14	of	of	ADP
fnp-3500	414	15	this	this	DET
fnp-3500	414	16	organelle	organelle	NOUN
fnp-3500	414	17	in	in	ADP
fnp-3500	414	18	the	the	DET
fnp-3500	414	19	perikarya	perikarya	NOUN
fnp-3500	414	20	of	of	ADP
fnp-3500	414	21	pyramidal	pyramidal	ADJ
fnp-3500	414	22	cells	cell	NOUN
fnp-3500	414	23	in	in	ADP
fnp-3500	414	24	the	the	DET
fnp-3500	414	25	hippocampus	hippocampus	NOUN
fnp-3500	414	26	(	(	PUNCT
fnp-3500	414	27	cornu	cornu	NOUN
fnp-3500	414	28	ammonis	ammonis	ADJ
fnp-3500	414	29	,	,	PUNCT
fnp-3500	414	30	subiculum	subiculum	NOUN
fnp-3500	414	31	and	and	CCONJ
fnp-3500	414	32	the	the	DET
fnp-3500	414	33	entorhinal	entorhinal	ADJ
fnp-3500	414	34	cortex	cortex	NOUN
fnp-3500	414	35	layer	layer	NOUN
fnp-3500	414	36	iii	iii	PROPN
fnp-3500	414	37	)	)	PUNCT
fnp-3500	414	38	as	as	ADV
fnp-3500	414	39	well	well	ADV
fnp-3500	414	40	as	as	ADP
fnp-3500	414	41	neocortical	neocortical	ADJ
fnp-3500	414	42	regions	region	NOUN
fnp-3500	414	43	(	(	PUNCT
fnp-3500	414	44	frontal	frontal	ADJ
fnp-3500	414	45	,	,	PUNCT
fnp-3500	414	46	temporal	temporal	ADJ
fnp-3500	414	47	,	,	PUNCT
fnp-3500	414	48	parietal	parietal	ADJ
fnp-3500	414	49	und	und	NOUN
fnp-3500	414	50	occipital	occipital	NOUN
fnp-3500	414	51	)	)	PUNCT
fnp-3500	414	52	of	of	ADP
fnp-3500	414	53	brain	brain	NOUN
fnp-3500	414	54	from	from	ADP
fnp-3500	414	55	patients	patient	NOUN
fnp-3500	414	56	with	with	ADP
fnp-3500	414	57	different	different	ADJ
fnp-3500	414	58	neuropathological	neuropathological	ADJ
fnp-3500	414	59	stages	stage	NOUN
fnp-3500	414	60	.	.	PUNCT
fnp-3500	415	1	we	we	PRON
fnp-3500	415	2	used	use	VERB
fnp-3500	415	3	double	double	ADJ
fnp-3500	415	4	immunofluorescence	immunofluorescence	NOUN
fnp-3500	415	5	staining	stain	VERB
fnp-3500	415	6	techniques	technique	NOUN
fnp-3500	415	7	to	to	PART
fnp-3500	415	8	detect	detect	VERB
fnp-3500	415	9	pex14	pex14	NOUN
fnp-3500	415	10	(	(	PUNCT
fnp-3500	415	11	as	as	ADP
fnp-3500	415	12	marker	marker	NOUN
fnp-3500	415	13	for	for	ADP
fnp-3500	415	14	the	the	DET
fnp-3500	415	15	total	total	ADJ
fnp-3500	415	16	peroxisome	peroxisome	PROPN
fnp-3500	415	17	numerical	numerical	PROPN
fnp-3500	415	18	abundance	abundance	PROPN
fnp-3500	415	19	)	)	PUNCT
fnp-3500	415	20	and	and	CCONJ
fnp-3500	415	21	β	β	X
fnp-3500	415	22	-	-	ADJ
fnp-3500	415	23	amlyoid	amlyoid	ADJ
fnp-3500	415	24	plaques	plaque	NOUN
fnp-3500	415	25	or	or	CCONJ
fnp-3500	415	26	neurofibrillary	neurofibrillary	ADJ
fnp-3500	415	27	tangles	tangle	NOUN
fnp-3500	415	28	(	(	PUNCT
fnp-3500	415	29	nfts)s	nfts)s	NOUN
fnp-3500	415	30	in	in	ADP
fnp-3500	415	31	different	different	ADJ
fnp-3500	415	32	brain	brain	NOUN
fnp-3500	415	33	regions	region	NOUN
fnp-3500	415	34	.	.	PUNCT
fnp-3500	416	1	human	human	ADJ
fnp-3500	416	2	brains	brain	NOUN
fnp-3500	416	3	were	be	AUX
fnp-3500	416	4	genderand	genderand	NOUN
fnp-3500	416	5	age	age	NOUN
fnp-3500	416	6	-	-	PUNCT
fnp-3500	416	7	matched	match	VERB
fnp-3500	416	8	and	and	CCONJ
fnp-3500	416	9	classified	classify	VERB
fnp-3500	416	10	into	into	ADP
fnp-3500	416	11	5	5	NUM
fnp-3500	416	12	patient	patient	ADJ
fnp-3500	416	13	groups	group	NOUN
fnp-3500	416	14	based	base	VERB
fnp-3500	416	15	to	to	ADP
fnp-3500	416	16	the	the	DET
fnp-3500	416	17	abc	abc	PROPN
fnp-3500	416	18	-	-	PUNCT
fnp-3500	416	19	score	score	NOUN
fnp-3500	416	20	.	.	PUNCT
fnp-3500	417	1	all	all	DET
fnp-3500	417	2	42	42	NUM
fnp-3500	417	3	brain	brain	NOUN
fnp-3500	417	4	samples	sample	NOUN
fnp-3500	417	5	were	be	AUX
fnp-3500	417	6	from	from	ADP
fnp-3500	417	7	the	the	DET
fnp-3500	417	8	institute	institute	NOUN
fnp-3500	417	9	of	of	ADP
fnp-3500	417	10	neuropathology	neuropathology	NOUN
fnp-3500	417	11	in	in	ADP
fnp-3500	417	12	gießen	gießen	NOUN
fnp-3500	417	13	.	.	PUNCT
fnp-3500	418	1	quantification	quantification	NOUN
fnp-3500	418	2	of	of	ADP
fnp-3500	418	3	peroxisome	peroxisome	NOUN
fnp-3500	418	4	number	number	NOUN
fnp-3500	418	5	per	per	ADP
fnp-3500	418	6	area	area	NOUN
fnp-3500	418	7	(	(	PUNCT
fnp-3500	418	8	density	density	NOUN
fnp-3500	418	9	)	)	PUNCT
fnp-3500	418	10	was	be	AUX
fnp-3500	418	11	performed	perform	VERB
fnp-3500	418	12	by	by	ADP
fnp-3500	418	13	imagej	imagej	ADJ
fnp-3500	418	14	free	free	ADJ
fnp-3500	418	15	software	software	NOUN
fnp-3500	418	16	.	.	PUNCT
fnp-3500	419	1	with	with	ADP
fnp-3500	419	2	ongoing	ongoing	ADJ
fnp-3500	419	3	stages	stage	NOUN
fnp-3500	419	4	of	of	ADP
fnp-3500	419	5	ad	ad	NOUN
fnp-3500	419	6	,	,	PUNCT
fnp-3500	419	7	we	we	PRON
fnp-3500	419	8	measured	measure	VERB
fnp-3500	419	9	a	a	DET
fnp-3500	419	10	progressive	progressive	ADJ
fnp-3500	419	11	decline	decline	NOUN
fnp-3500	419	12	in	in	ADP
fnp-3500	419	13	the	the	DET
fnp-3500	419	14	density	density	NOUN
fnp-3500	419	15	of	of	ADP
fnp-3500	419	16	peroxisomes	peroxisome	NOUN
fnp-3500	419	17	in	in	ADP
fnp-3500	419	18	pyramidal	pyramidal	ADJ
fnp-3500	419	19	cells	cell	NOUN
fnp-3500	419	20	of	of	ADP
fnp-3500	419	21	all	all	DET
fnp-3500	419	22	hippocampal	hippocampal	ADJ
fnp-3500	419	23	and	and	CCONJ
fnp-3500	419	24	neocortical	neocortical	ADJ
fnp-3500	419	25	areas	area	NOUN
fnp-3500	419	26	.	.	PUNCT
fnp-3500	420	1	the	the	DET
fnp-3500	420	2	effect	effect	NOUN
fnp-3500	420	3	was	be	AUX
fnp-3500	420	4	even	even	ADV
fnp-3500	420	5	more	more	ADV
fnp-3500	420	6	pronounced	pronounced	ADJ
fnp-3500	420	7	when	when	SCONJ
fnp-3500	420	8	we	we	PRON
fnp-3500	420	9	included	include	VERB
fnp-3500	420	10	known	know	VERB
fnp-3500	420	11	ad	ad	NOUN
fnp-3500	420	12	risk	risk	NOUN
fnp-3500	420	13	factors	factor	NOUN
fnp-3500	420	14	such	such	ADJ
fnp-3500	420	15	as	as	ADP
fnp-3500	420	16	vascular	vascular	ADJ
fnp-3500	420	17	angiopathies	angiopathy	NOUN
fnp-3500	420	18	.	.	PUNCT
fnp-3500	421	1	interestingly	interestingly	ADV
fnp-3500	421	2	,	,	PUNCT
fnp-3500	421	3	the	the	DET
fnp-3500	421	4	decrease	decrease	NOUN
fnp-3500	421	5	in	in	ADP
fnp-3500	421	6	the	the	DET
fnp-3500	421	7	density	density	NOUN
fnp-3500	421	8	of	of	ADP
fnp-3500	421	9	peroxisomes	peroxisome	NOUN
fnp-3500	421	10	at	at	ADP
fnp-3500	421	11	late	late	ADJ
fnp-3500	421	12	stages	stage	NOUN
fnp-3500	421	13	in	in	ADP
fnp-3500	421	14	ad	ad	NOUN
fnp-3500	421	15	was	be	AUX
fnp-3500	421	16	more	more	ADV
fnp-3500	421	17	evident	evident	ADJ
fnp-3500	421	18	in	in	ADP
fnp-3500	421	19	patients	patient	NOUN
fnp-3500	421	20	≤80	≤80	PROPN
fnp-3500	421	21	years	year	NOUN
fnp-3500	421	22	old	old	ADJ
fnp-3500	421	23	than	than	ADP
fnp-3500	421	24	in	in	ADP
fnp-3500	421	25	patients	patient	NOUN
fnp-3500	421	26	>	>	PUNCT
fnp-3500	421	27	81	81	NUM
fnp-3500	421	28	years	year	NOUN
fnp-3500	421	29	old	old	ADJ
fnp-3500	421	30	.	.	PUNCT
fnp-3500	422	1	however	however	ADV
fnp-3500	422	2	,	,	PUNCT
fnp-3500	422	3	we	we	PRON
fnp-3500	422	4	did	do	AUX
fnp-3500	422	5	not	not	PART
fnp-3500	422	6	find	find	VERB
fnp-3500	422	7	a	a	DET
fnp-3500	422	8	correlation	correlation	NOUN
fnp-3500	422	9	between	between	ADP
fnp-3500	422	10	the	the	DET
fnp-3500	422	11	intraneuronal	intraneuronal	PROPN
fnp-3500	422	12	peroxisome	peroxisome	NOUN
fnp-3500	422	13	density	density	NOUN
fnp-3500	422	14	and	and	CCONJ
fnp-3500	422	15	the	the	DET
fnp-3500	422	16	amount	amount	NOUN
fnp-3500	422	17	of	of	ADP
fnp-3500	422	18	β	β	NOUN
fnp-3500	422	19	-	-	NOUN
fnp-3500	422	20	amyloid	amyloid	NOUN
fnp-3500	422	21	and	and	CCONJ
fnp-3500	422	22	nfts	nft	NOUN
fnp-3500	422	23	.	.	PUNCT
fnp-3500	423	1	our	our	PRON
fnp-3500	423	2	data	datum	NOUN
fnp-3500	423	3	suggest	suggest	VERB
fnp-3500	423	4	that	that	SCONJ
fnp-3500	423	5	peroxisomes	peroxisome	NOUN
fnp-3500	423	6	may	may	AUX
fnp-3500	423	7	play	play	VERB
fnp-3500	423	8	a	a	DET
fnp-3500	423	9	protective	protective	ADJ
fnp-3500	423	10	role	role	NOUN
fnp-3500	423	11	in	in	ADP
fnp-3500	423	12	ad	ad	NOUN
fnp-3500	423	13	and	and	CCONJ
fnp-3500	423	14	their	their	PRON
fnp-3500	423	15	decline	decline	NOUN
fnp-3500	423	16	in	in	ADP
fnp-3500	423	17	numerical	numerical	ADJ
fnp-3500	423	18	density	density	NOUN
fnp-3500	423	19	–	–	PUNCT
fnp-3500	423	20	especially	especially	ADV
fnp-3500	423	21	in	in	ADP
fnp-3500	423	22	the	the	DET
fnp-3500	423	23	hippocampus	hippocampus	NOUN
fnp-3500	423	24	–	–	PUNCT
fnp-3500	423	25	occurs	occur	VERB
fnp-3500	423	26	late	late	ADV
fnp-3500	423	27	during	during	ADP
fnp-3500	423	28	ad	ad	NOUN
fnp-3500	423	29	progression	progression	NOUN
fnp-3500	423	30	.	.	PUNCT
fnp-3500	423	31	  	  	SPACE
fnp-3500	424	1	piv-05	piv-05	NOUN
fnp-3500	424	2	free	free	ADJ
fnp-3500	424	3	neuropathol	neuropathol	NOUN
fnp-3500	424	4	2:22:46	2:22:46	NUM
fnp-3500	424	5	its	its	PRON
fnp-3500	424	6	not	not	PART
fnp-3500	424	7	all	all	ADV
fnp-3500	424	8	about	about	ADP
fnp-3500	424	9	covid19	covid19	NOUN
fnp-3500	424	10	incidental	incidental	ADJ
fnp-3500	424	11	finding	finding	NOUN
fnp-3500	424	12	of	of	ADP
fnp-3500	424	13	hereditary	hereditary	ADJ
fnp-3500	424	14	neuroferritinopathy	neuroferritinopathy	NOUN
fnp-3500	424	15	in	in	ADP
fnp-3500	424	16	a	a	DET
fnp-3500	424	17	78	78	NUM
fnp-3500	424	18	-	-	PUNCT
fnp-3500	424	19	year	year	NOUN
fnp-3500	424	20	-	-	PUNCT
fnp-3500	424	21	old	old	ADJ
fnp-3500	424	22	woman	woman	NOUN
fnp-3500	424	23	diagnosed	diagnose	VERB
fnp-3500	424	24	with	with	ADP
fnp-3500	424	25	covid-19	covid-19	PROPN
fnp-3500	424	26	associated	associated	ADJ
fnp-3500	424	27	pneumonia	pneumonia	NOUN
fnp-3500	424	28	v.	v.	ADP
fnp-3500	424	29	umathum1,2	umathum1,2	PROPN
fnp-3500	424	30	,	,	PUNCT
fnp-3500	424	31	d.	d.	PROPN
fnp-3500	424	32	amsel1	amsel1	PROPN
fnp-3500	424	33	,	,	PUNCT
fnp-3500	424	34	a.	a.	PROPN
fnp-3500	424	35	weber3	weber3	PROPN
fnp-3500	424	36	,	,	PUNCT
fnp-3500	424	37	c.	c.	PROPN
fnp-3500	424	38	becker4	becker4	PROPN
fnp-3500	424	39	,	,	PUNCT
fnp-3500	424	40	c.	c.	PROPN
fnp-3500	424	41	kasan4	kasan4	PROPN
fnp-3500	424	42	,	,	PUNCT
fnp-3500	424	43	a.	a.	NOUN
fnp-3500	424	44	may5	may5	PROPN
fnp-3500	424	45	,	,	PUNCT
fnp-3500	424	46	t.	t.	PROPN
fnp-3500	424	47	acker1	acker1	PROPN
fnp-3500	424	48	,	,	PUNCT
fnp-3500	424	49	a.	a.	PROPN
fnp-3500	424	50	schänzer1	schänzer1	PROPN
fnp-3500	424	51	1	1	NUM
fnp-3500	424	52	justus	justus	PROPN
fnp-3500	424	53	-	-	PUNCT
fnp-3500	424	54	liebig	liebig	NOUN
fnp-3500	424	55	-	-	PUNCT
fnp-3500	424	56	university	university	NOUN
fnp-3500	424	57	gießen	gießen	NOUN
fnp-3500	424	58	,	,	PUNCT
fnp-3500	424	59	institute	institute	NOUN
fnp-3500	424	60	of	of	ADP
fnp-3500	424	61	neuropathology	neuropathology	NOUN
fnp-3500	424	62	,	,	PUNCT
fnp-3500	424	63	gießen	gießen	PROPN
fnp-3500	424	64	,	,	PUNCT
fnp-3500	424	65	germany	germany	PROPN
fnp-3500	424	66	2	2	NUM
fnp-3500	424	67	bundeswehrkrankenhaus	bundeswehrkrankenhaus	PROPN
fnp-3500	424	68	ulm	ulm	PROPN
fnp-3500	424	69	,	,	PUNCT
fnp-3500	424	70	institute	institute	NOUN
fnp-3500	424	71	of	of	ADP
fnp-3500	424	72	pathology	pathology	PROPN
fnp-3500	424	73	and	and	CCONJ
fnp-3500	424	74	molecular	molecular	ADJ
fnp-3500	424	75	pathology	pathology	NOUN
fnp-3500	424	76	,	,	PUNCT
fnp-3500	424	77	ulm	ulm	PROPN
fnp-3500	424	78	,	,	PUNCT
fnp-3500	424	79	germany	germany	PROPN
fnp-3500	424	80	3	3	NUM
fnp-3500	424	81	justus	justus	PROPN
fnp-3500	424	82	-	-	PUNCT
fnp-3500	424	83	liebig	liebig	NOUN
fnp-3500	424	84	-	-	PUNCT
fnp-3500	424	85	university	university	NOUN
fnp-3500	424	86	gießen	gießen	NOUN
fnp-3500	424	87	,	,	PUNCT
fnp-3500	424	88	institute	institute	NOUN
fnp-3500	424	89	of	of	ADP
fnp-3500	424	90	human	human	ADJ
fnp-3500	424	91	genetics	genetic	NOUN
fnp-3500	424	92	,	,	PUNCT
fnp-3500	424	93	gießen	gießen	PROPN
fnp-3500	424	94	,	,	PUNCT
fnp-3500	424	95	germany	germany	PROPN
fnp-3500	424	96	4	4	NUM
fnp-3500	424	97	institute	institute	PROPN
fnp-3500	424	98	of	of	ADP
fnp-3500	424	99	pathology	pathology	PROPN
fnp-3500	424	100	,	,	PUNCT
fnp-3500	424	101	cytology	cytology	NOUN
fnp-3500	424	102	and	and	CCONJ
fnp-3500	424	103	molecular	molecular	ADJ
fnp-3500	424	104	pathology	pathology	NOUN
fnp-3500	424	105	,	,	PUNCT
fnp-3500	424	106	wetzlar	wetzlar	ADJ
fnp-3500	424	107	,	,	PUNCT
fnp-3500	424	108	germany	germany	PROPN
fnp-3500	424	109	5	5	NUM
fnp-3500	424	110	agaplesion	agaplesion	NOUN
fnp-3500	424	111	evangelisches	evangelisches	ADP
fnp-3500	424	112	krankenhaus	krankenhaus	PROPN
fnp-3500	424	113	,	,	PUNCT
fnp-3500	424	114	department	department	PROPN
fnp-3500	424	115	of	of	ADP
fnp-3500	424	116	pulmonology	pulmonology	NOUN
fnp-3500	424	117	,	,	PUNCT
fnp-3500	424	118	gießen	gießen	PROPN
fnp-3500	424	119	,	,	PUNCT
fnp-3500	424	120	germany	germany	PROPN
fnp-3500	424	121	introduction	introduction	NOUN
fnp-3500	424	122	:	:	PUNCT
fnp-3500	424	123	neuroferritinopathy	neuroferritinopathy	ADJ
fnp-3500	424	124	(	(	PUNCT
fnp-3500	424	125	nf	nf	INTJ
fnp-3500	424	126	)	)	PUNCT
fnp-3500	424	127	is	be	AUX
fnp-3500	424	128	an	an	DET
fnp-3500	424	129	autosomal	autosomal	ADJ
fnp-3500	424	130	-	-	PUNCT
fnp-3500	424	131	dominant	dominant	NOUN
fnp-3500	424	132	movement	movement	NOUN
fnp-3500	424	133	disorder	disorder	NOUN
fnp-3500	424	134	due	due	ADP
fnp-3500	424	135	to	to	ADP
fnp-3500	424	136	mutations	mutation	NOUN
fnp-3500	424	137	in	in	ADP
fnp-3500	424	138	the	the	DET
fnp-3500	424	139	l	l	NOUN
fnp-3500	424	140	-	-	ADJ
fnp-3500	424	141	ferritin	ferritin	ADJ
fnp-3500	424	142	gene	gene	NOUN
fnp-3500	424	143	(	(	PUNCT
fnp-3500	424	144	ftl	ftl	NOUN
fnp-3500	424	145	)	)	PUNCT
fnp-3500	424	146	on	on	ADP
fnp-3500	424	147	chromosome	chromosome	NOUN
fnp-3500	424	148	19q13.33	19q13.33	NUM
fnp-3500	424	149	.	.	PUNCT
fnp-3500	425	1	nf	nf	PROPN
fnp-3500	425	2	belongs	belong	VERB
fnp-3500	425	3	to	to	ADP
fnp-3500	425	4	neurodegeneration	neurodegeneration	NOUN
fnp-3500	425	5	with	with	ADP
fnp-3500	425	6	brain	brain	NOUN
fnp-3500	425	7	iron	iron	NOUN
fnp-3500	425	8	accumulation	accumulation	NOUN
fnp-3500	425	9	(	(	PUNCT
fnp-3500	425	10	nbia	nbia	NOUN
fnp-3500	425	11	)	)	PUNCT
fnp-3500	425	12	disorders	disorder	NOUN
fnp-3500	425	13	,	,	PUNCT
fnp-3500	425	14	a	a	DET
fnp-3500	425	15	group	group	NOUN
fnp-3500	425	16	of	of	ADP
fnp-3500	425	17	hereditary	hereditary	ADJ
fnp-3500	425	18	neurodegenerative	neurodegenerative	ADJ
fnp-3500	425	19	diseases	disease	NOUN
fnp-3500	425	20	with	with	ADP
fnp-3500	425	21	a	a	DET
fnp-3500	425	22	prevalence	prevalence	NOUN
fnp-3500	425	23	of	of	ADP
fnp-3500	425	24	1/1.000.000	1/1.000.000	NUM
fnp-3500	425	25	.	.	PUNCT
fnp-3500	426	1	patients	patient	NOUN
fnp-3500	426	2	with	with	ADP
fnp-3500	426	3	nf	nf	ADJ
fnp-3500	426	4	present	present	ADJ
fnp-3500	426	5	clinically	clinically	ADV
fnp-3500	426	6	with	with	ADP
fnp-3500	426	7	progressive	progressive	ADJ
fnp-3500	426	8	extrapyramidal	extrapyramidal	ADJ
fnp-3500	426	9	movement	movement	NOUN
fnp-3500	426	10	symptoms	symptom	NOUN
fnp-3500	426	11	with	with	ADP
fnp-3500	426	12	variable	variable	ADJ
fnp-3500	426	13	phenotype	phenotype	NOUN
fnp-3500	426	14	.	.	PUNCT
fnp-3500	427	1	histopathologically	histopathologically	ADV
fnp-3500	427	2	,	,	PUNCT
fnp-3500	427	3	nf	nf	X
fnp-3500	427	4	is	be	AUX
fnp-3500	427	5	characterized	characterize	VERB
fnp-3500	427	6	by	by	ADP
fnp-3500	427	7	iron	iron	NOUN
fnp-3500	427	8	deposits	deposit	NOUN
fnp-3500	427	9	and	and	CCONJ
fnp-3500	427	10	formation	formation	NOUN
fnp-3500	427	11	of	of	ADP
fnp-3500	427	12	ferritin	ferritin	ADJ
fnp-3500	427	13	inclusion	inclusion	NOUN
fnp-3500	427	14	bodies	body	NOUN
fnp-3500	427	15	(	(	PUNCT
fnp-3500	427	16	ibs	ibs	PROPN
fnp-3500	427	17	)	)	PUNCT
fnp-3500	427	18	.	.	PUNCT
fnp-3500	428	1	clinical	clinical	ADJ
fnp-3500	428	2	history	history	NOUN
fnp-3500	428	3	:	:	PUNCT
fnp-3500	428	4	a	a	DET
fnp-3500	428	5	78	78	NUM
fnp-3500	428	6	-	-	PUNCT
fnp-3500	428	7	year	year	NOUN
fnp-3500	428	8	-	-	PUNCT
fnp-3500	428	9	old	old	ADJ
fnp-3500	428	10	woman	woman	NOUN
fnp-3500	428	11	was	be	AUX
fnp-3500	428	12	hospitalized	hospitalize	VERB
fnp-3500	428	13	with	with	ADP
fnp-3500	428	14	a	a	DET
fnp-3500	428	15	severe	severe	ADJ
fnp-3500	428	16	covid-19	covid-19	PROPN
fnp-3500	428	17	pneumonia	pneumonia	NOUN
fnp-3500	428	18	and	and	CCONJ
fnp-3500	428	19	after	after	ADP
fnp-3500	428	20	three	three	NUM
fnp-3500	428	21	months	month	NOUN
fnp-3500	428	22	died	die	VERB
fnp-3500	428	23	from	from	ADP
fnp-3500	428	24	covid19	covid19	NOUN
fnp-3500	428	25	-	-	PUNCT
fnp-3500	428	26	associated	associate	VERB
fnp-3500	428	27	pneumonia	pneumonia	NOUN
fnp-3500	428	28	.	.	PUNCT
fnp-3500	429	1	during	during	ADP
fnp-3500	429	2	her	her	PRON
fnp-3500	429	3	3	3	NUM
fnp-3500	429	4	-	-	PUNCT
fnp-3500	429	5	month	month	NOUN
fnp-3500	429	6	clinical	clinical	ADJ
fnp-3500	429	7	course	course	NOUN
fnp-3500	429	8	she	she	PRON
fnp-3500	429	9	showed	show	VERB
fnp-3500	429	10	neurological	neurological	ADJ
fnp-3500	429	11	symptoms	symptom	NOUN
fnp-3500	429	12	of	of	ADP
fnp-3500	429	13	delirium	delirium	NOUN
fnp-3500	429	14	and	and	CCONJ
fnp-3500	429	15	restlessness	restlessness	NOUN
fnp-3500	429	16	.	.	PUNCT
fnp-3500	430	1	cranial	cranial	ADJ
fnp-3500	430	2	mri	mri	NOUN
fnp-3500	430	3	was	be	AUX
fnp-3500	430	4	not	not	PART
fnp-3500	430	5	performed	perform	VERB
fnp-3500	430	6	.	.	PUNCT
fnp-3500	431	1	neuropathological	neuropathological	ADJ
fnp-3500	431	2	findings	finding	NOUN
fnp-3500	431	3	:	:	PUNCT
fnp-3500	431	4	brain	brain	NOUN
fnp-3500	431	5	weight	weight	NOUN
fnp-3500	431	6	was	be	AUX
fnp-3500	431	7	1172	1172	NUM
fnp-3500	431	8	g.	g.	NOUN
fnp-3500	432	1	no	no	DET
fnp-3500	432	2	abnormalities	abnormality	NOUN
fnp-3500	432	3	were	be	AUX
fnp-3500	432	4	seen	see	VERB
fnp-3500	432	5	in	in	ADP
fnp-3500	432	6	cross	cross	NOUN
fnp-3500	432	7	sections	section	NOUN
fnp-3500	432	8	.	.	PUNCT
fnp-3500	433	1	histological	histological	ADJ
fnp-3500	433	2	examination	examination	NOUN
fnp-3500	433	3	revealed	reveal	VERB
fnp-3500	433	4	frequent	frequent	ADJ
fnp-3500	433	5	atypical	atypical	ADJ
fnp-3500	433	6	iron	iron	NOUN
fnp-3500	433	7	accumulation	accumulation	NOUN
fnp-3500	433	8	throughout	throughout	ADP
fnp-3500	433	9	the	the	DET
fnp-3500	433	10	brain	brain	NOUN
fnp-3500	433	11	particularly	particularly	ADV
fnp-3500	433	12	in	in	ADP
fnp-3500	433	13	the	the	DET
fnp-3500	433	14	basal	basal	ADJ
fnp-3500	433	15	ganglia	ganglia	NOUN
fnp-3500	433	16	.	.	PUNCT
fnp-3500	434	1	the	the	DET
fnp-3500	434	2	nuclear	nuclear	ADJ
fnp-3500	434	3	spherical	spherical	ADJ
fnp-3500	434	4	iron	iron	NOUN
fnp-3500	434	5	inclusions	inclusion	NOUN
fnp-3500	434	6	were	be	AUX
fnp-3500	434	7	localized	localize	VERB
fnp-3500	434	8	in	in	ADP
fnp-3500	434	9	neurons	neuron	NOUN
fnp-3500	434	10	,	,	PUNCT
fnp-3500	434	11	microglia	microglia	ADJ
fnp-3500	434	12	and	and	CCONJ
fnp-3500	434	13	oligodendrocytes	oligodendrocyte	NOUN
fnp-3500	434	14	stained	stain	VERB
fnp-3500	434	15	for	for	ADP
fnp-3500	434	16	prussian	prussian	ADJ
fnp-3500	434	17	blue	blue	NOUN
fnp-3500	434	18	and	and	CCONJ
fnp-3500	434	19	immunohistochemically	immunohistochemically	ADV
fnp-3500	434	20	with	with	ADP
fnp-3500	434	21	antibodies	antibody	NOUN
fnp-3500	434	22	against	against	ADP
fnp-3500	434	23	anti	anti	ADJ
fnp-3500	434	24	-	-	ADJ
fnp-3500	434	25	ferritin	ferritin	ADJ
fnp-3500	434	26	light	light	ADJ
fnp-3500	434	27	chain	chain	NOUN
fnp-3500	434	28	.	.	PUNCT
fnp-3500	435	1	electron	electron	NOUN
fnp-3500	435	2	microscopy	microscopy	NOUN
fnp-3500	435	3	showed	show	VERB
fnp-3500	435	4	fragmented	fragmented	ADJ
fnp-3500	435	5	nuclei	nucleus	NOUN
fnp-3500	435	6	with	with	ADP
fnp-3500	435	7	inclusions	inclusion	NOUN
fnp-3500	435	8	and	and	CCONJ
fnp-3500	435	9	chromatin	chromatin	NOUN
fnp-3500	435	10	accumulation	accumulation	NOUN
fnp-3500	435	11	toward	toward	ADP
fnp-3500	435	12	the	the	DET
fnp-3500	435	13	membrane	membrane	NOUN
fnp-3500	435	14	consistent	consistent	ADJ
fnp-3500	435	15	with	with	ADP
fnp-3500	435	16	ibs	ibs	PROPN
fnp-3500	435	17	.	.	PUNCT
fnp-3500	435	18	moderate	moderate	ADJ
fnp-3500	435	19	microcystic	microcystic	ADJ
fnp-3500	435	20	vacuolization	vacuolization	NOUN
fnp-3500	435	21	and	and	CCONJ
fnp-3500	435	22	partial	partial	ADJ
fnp-3500	435	23	loss	loss	NOUN
fnp-3500	435	24	of	of	ADP
fnp-3500	435	25	myelination	myelination	NOUN
fnp-3500	435	26	of	of	ADP
fnp-3500	435	27	nerve	nerve	NOUN
fnp-3500	435	28	fibres	fibre	NOUN
fnp-3500	435	29	were	be	AUX
fnp-3500	435	30	evident	evident	ADJ
fnp-3500	435	31	.	.	PUNCT
fnp-3500	436	1	discussion	discussion	NOUN
fnp-3500	436	2	and	and	CCONJ
fnp-3500	436	3	conclusion:131	conclusion:131	NOUN
fnp-3500	436	4	cases	case	NOUN
fnp-3500	436	5	of	of	ADP
fnp-3500	436	6	nf	nf	NOUN
fnp-3500	436	7	have	have	AUX
fnp-3500	436	8	been	be	AUX
fnp-3500	436	9	described	describe	VERB
fnp-3500	436	10	so	so	ADV
fnp-3500	436	11	far	far	ADV
fnp-3500	436	12	in	in	ADP
fnp-3500	436	13	the	the	DET
fnp-3500	436	14	literature	literature	NOUN
fnp-3500	436	15	with	with	ADP
fnp-3500	436	16	80	80	NUM
fnp-3500	436	17	%	%	NOUN
fnp-3500	436	18	in	in	ADP
fnp-3500	436	19	france	france	PROPN
fnp-3500	436	20	and	and	CCONJ
fnp-3500	436	21	the	the	DET
fnp-3500	436	22	uk	uk	PROPN
fnp-3500	436	23	and	and	CCONJ
fnp-3500	436	24	20	20	NUM
fnp-3500	436	25	%	%	NOUN
fnp-3500	436	26	throughout	throughout	ADP
fnp-3500	436	27	the	the	DET
fnp-3500	436	28	world	world	NOUN
fnp-3500	436	29	.	.	PUNCT
fnp-3500	437	1	movement	movement	NOUN
fnp-3500	437	2	disorders	disorder	NOUN
fnp-3500	437	3	or	or	CCONJ
fnp-3500	437	4	cognitive	cognitive	ADJ
fnp-3500	437	5	impairments	impairment	NOUN
fnp-3500	437	6	were	be	AUX
fnp-3500	437	7	not	not	PART
fnp-3500	437	8	reported	report	VERB
fnp-3500	437	9	in	in	ADP
fnp-3500	437	10	our	our	PRON
fnp-3500	437	11	patient	patient	NOUN
fnp-3500	437	12	,	,	PUNCT
fnp-3500	437	13	maybe	maybe	ADV
fnp-3500	437	14	due	due	ADP
fnp-3500	437	15	to	to	ADP
fnp-3500	437	16	a	a	DET
fnp-3500	437	17	lack	lack	NOUN
fnp-3500	437	18	of	of	ADP
fnp-3500	437	19	full	full	ADJ
fnp-3500	437	20	penetrance	penetrance	NOUN
fnp-3500	437	21	that	that	PRON
fnp-3500	437	22	occurs	occur	VERB
fnp-3500	437	23	at	at	ADP
fnp-3500	437	24	the	the	DET
fnp-3500	437	25	age	age	NOUN
fnp-3500	437	26	of	of	ADP
fnp-3500	437	27	60	60	NUM
fnp-3500	437	28	,	,	PUNCT
fnp-3500	437	29	in	in	ADP
fnp-3500	437	30	general	general	ADJ
fnp-3500	437	31	.	.	PUNCT
fnp-3500	438	1	in	in	ADP
fnp-3500	438	2	our	our	PRON
fnp-3500	438	3	patient	patient	NOUN
fnp-3500	438	4	,	,	PUNCT
fnp-3500	438	5	the	the	DET
fnp-3500	438	6	brain	brain	NOUN
fnp-3500	438	7	pathology	pathology	NOUN
fnp-3500	438	8	is	be	AUX
fnp-3500	438	9	suspicious	suspicious	ADJ
fnp-3500	438	10	for	for	ADP
fnp-3500	438	11	a	a	DET
fnp-3500	438	12	nf	nf	NOUN
fnp-3500	438	13	.	.	PUNCT
fnp-3500	439	1	most	most	ADJ
fnp-3500	439	2	of	of	ADP
fnp-3500	439	3	the	the	DET
fnp-3500	439	4	patients	patient	NOUN
fnp-3500	439	5	harbour	harbour	VERB
fnp-3500	439	6	an	an	DET
fnp-3500	439	7	adenine	adenine	ADJ
fnp-3500	439	8	insertion	insertion	NOUN
fnp-3500	439	9	at	at	ADP
fnp-3500	439	10	position	position	NOUN
fnp-3500	439	11	460	460	NUM
fnp-3500	439	12	-	-	SYM
fnp-3500	439	13	461	461	NUM
fnp-3500	439	14	of	of	ADP
fnp-3500	439	15	the	the	DET
fnp-3500	439	16	ftl	ftl	NOUN
fnp-3500	439	17	-	-	PUNCT
fnp-3500	439	18	gene	gene	NOUN
fnp-3500	439	19	.	.	PUNCT
fnp-3500	440	1	whole	whole	ADJ
fnp-3500	440	2	exome	exome	NOUN
fnp-3500	440	3	sequencing	sequence	VERB
fnp-3500	440	4	from	from	ADP
fnp-3500	440	5	brain	brain	NOUN
fnp-3500	440	6	tissue	tissue	NOUN
fnp-3500	440	7	is	be	AUX
fnp-3500	440	8	in	in	ADP
fnp-3500	440	9	progress	progress	NOUN
fnp-3500	440	10	to	to	PART
fnp-3500	440	11	confirm	confirm	VERB
fnp-3500	440	12	the	the	DET
fnp-3500	440	13	diagnosis	diagnosis	NOUN
fnp-3500	440	14	.	.	PUNCT
fnp-3500	440	15	  	  	SPACE
fnp-3500	441	1	piv-06	piv-06	NOUN
fnp-3500	441	2	free	free	ADJ
fnp-3500	441	3	neuropathol	neuropathol	NOUN
fnp-3500	441	4	2:22:47	2:22:47	NUM
fnp-3500	441	5	role	role	NOUN
fnp-3500	441	6	of	of	ADP
fnp-3500	441	7	purinergic	purinergic	NOUN
fnp-3500	441	8	receptor	receptor	NOUN
fnp-3500	441	9	p2y12	p2y12	PROPN
fnp-3500	441	10	in	in	ADP
fnp-3500	441	11	alzheimer	alzheimer	PROPN
fnp-3500	441	12	's	's	PART
fnp-3500	441	13	disease	disease	NOUN
fnp-3500	441	14	r.	r.	PROPN
fnp-3500	441	15	maruccia1,2	maruccia1,2	PROPN
fnp-3500	441	16	,	,	PUNCT
fnp-3500	441	17	a.	a.	NOUN
fnp-3500	441	18	a.	a.	NOUN
fnp-3500	441	19	gabr1	gabr1	PROPN
fnp-3500	441	20	,	,	PUNCT
fnp-3500	441	21	m.	m.	PROPN
fnp-3500	441	22	j.	j.	PROPN
fnp-3500	441	23	pietrowski1	pietrowski1	PROPN
fnp-3500	441	24	,	,	PUNCT
fnp-3500	441	25	b.	b.	PROPN
fnp-3500	441	26	a.	a.	PROPN
fnp-3500	441	27	tambe1	tambe1	PROPN
fnp-3500	441	28	,	,	PUNCT
fnp-3500	441	29	a.	a.	PROPN
fnp-3500	441	30	halle1,2	halle1,2	PROPN
fnp-3500	441	31	1	1	NUM
fnp-3500	441	32	deutsches	deutsche	NOUN
fnp-3500	441	33	zentrum	zentrum	PROPN
fnp-3500	441	34	für	für	PROPN
fnp-3500	441	35	neurodegenerative	neurodegenerative	ADJ
fnp-3500	441	36	erkrankungen	erkrankungen	PROPN
fnp-3500	441	37	,	,	PUNCT
fnp-3500	441	38	bonn	bonn	PROPN
fnp-3500	441	39	,	,	PUNCT
fnp-3500	441	40	germany	germany	PROPN
fnp-3500	441	41	2	2	NUM
fnp-3500	441	42	universitätsklinikum	universitätsklinikum	NOUN
fnp-3500	441	43	bonn	bonn	PROPN
fnp-3500	441	44	,	,	PUNCT
fnp-3500	441	45	institut	institut	PROPN
fnp-3500	441	46	für	für	PROPN
fnp-3500	441	47	neuropathologie	neuropathologie	PROPN
fnp-3500	441	48	,	,	PUNCT
fnp-3500	441	49	bonn	bonn	PROPN
fnp-3500	441	50	,	,	PUNCT
fnp-3500	441	51	germany	germany	PROPN
fnp-3500	441	52	microglia	microglia	NOUN
fnp-3500	441	53	have	have	AUX
fnp-3500	441	54	recently	recently	ADV
fnp-3500	441	55	moved	move	VERB
fnp-3500	441	56	into	into	ADP
fnp-3500	441	57	prime	prime	ADJ
fnp-3500	441	58	focus	focus	NOUN
fnp-3500	441	59	of	of	ADP
fnp-3500	441	60	ad	ad	NOUN
fnp-3500	441	61	research	research	NOUN
fnp-3500	441	62	due	due	ADP
fnp-3500	441	63	to	to	ADP
fnp-3500	441	64	the	the	DET
fnp-3500	441	65	discovery	discovery	NOUN
fnp-3500	441	66	of	of	ADP
fnp-3500	441	67	risk	risk	NOUN
fnp-3500	441	68	loci	locus	NOUN
fnp-3500	441	69	and	and	CCONJ
fnp-3500	441	70	genes	gene	NOUN
fnp-3500	441	71	that	that	PRON
fnp-3500	441	72	are	be	AUX
fnp-3500	441	73	linked	link	VERB
fnp-3500	441	74	to	to	ADP
fnp-3500	441	75	immune	immune	ADJ
fnp-3500	441	76	mechanisms	mechanism	NOUN
fnp-3500	441	77	,	,	PUNCT
fnp-3500	441	78	some	some	PRON
fnp-3500	441	79	of	of	ADP
fnp-3500	441	80	them	they	PRON
fnp-3500	441	81	highly	highly	ADV
fnp-3500	441	82	expressed	express	VERB
fnp-3500	441	83	in	in	ADP
fnp-3500	441	84	microglia	microglia	NOUN
fnp-3500	441	85	.	.	PUNCT
fnp-3500	442	1	however	however	ADV
fnp-3500	442	2	,	,	PUNCT
fnp-3500	442	3	immune	immune	ADJ
fnp-3500	442	4	signaling	signal	VERB
fnp-3500	442	5	pathways	pathway	NOUN
fnp-3500	442	6	in	in	ADP
fnp-3500	442	7	microglia	microglia	NOUN
fnp-3500	442	8	that	that	PRON
fnp-3500	442	9	modulate	modulate	VERB
fnp-3500	442	10	ad	ad	NOUN
fnp-3500	442	11	progression	progression	NOUN
fnp-3500	442	12	,	,	PUNCT
fnp-3500	442	13	for	for	ADP
fnp-3500	442	14	example	example	NOUN
fnp-3500	442	15	by	by	ADP
fnp-3500	442	16	removing	remove	VERB
fnp-3500	442	17	aβ	aβ	ADP
fnp-3500	442	18	plaques	plaque	NOUN
fnp-3500	442	19	,	,	PUNCT
fnp-3500	442	20	have	have	AUX
fnp-3500	442	21	remained	remained	AUX
fnp-3500	442	22	poorly	poorly	ADV
fnp-3500	442	23	understood	understand	VERB
fnp-3500	442	24	.	.	PUNCT
fnp-3500	443	1	the	the	DET
fnp-3500	443	2	purinergic	purinergic	NOUN
fnp-3500	443	3	receptor	receptor	NOUN
fnp-3500	443	4	p2y12	p2y12	INTJ
fnp-3500	443	5	is	be	AUX
fnp-3500	443	6	activated	activate	VERB
fnp-3500	443	7	by	by	ADP
fnp-3500	443	8	extracellular	extracellular	ADJ
fnp-3500	443	9	atp	atp	PROPN
fnp-3500	443	10	and	and	CCONJ
fnp-3500	443	11	adp	adp	PROPN
fnp-3500	443	12	and	and	CCONJ
fnp-3500	443	13	is	be	AUX
fnp-3500	443	14	highly	highly	ADV
fnp-3500	443	15	expressed	express	VERB
fnp-3500	443	16	in	in	ADP
fnp-3500	443	17	platelets	platelet	NOUN
fnp-3500	443	18	and	and	CCONJ
fnp-3500	443	19	microglia	microglia	NOUN
fnp-3500	443	20	.	.	PUNCT
fnp-3500	444	1	p2y12	p2y12	PROPN
fnp-3500	444	2	is	be	AUX
fnp-3500	444	3	crucial	crucial	ADJ
fnp-3500	444	4	for	for	ADP
fnp-3500	444	5	several	several	ADJ
fnp-3500	444	6	microglial	microglial	ADJ
fnp-3500	444	7	functions	function	NOUN
fnp-3500	444	8	such	such	ADJ
fnp-3500	444	9	as	as	ADP
fnp-3500	444	10	chemotaxis	chemotaxis	ADJ
fnp-3500	444	11	,	,	PUNCT
fnp-3500	444	12	blood	blood	NOUN
fnp-3500	444	13	-	-	PUNCT
fnp-3500	444	14	brain	brain	NOUN
fnp-3500	444	15	barrier	barrier	NOUN
fnp-3500	444	16	closure	closure	NOUN
fnp-3500	444	17	,	,	PUNCT
fnp-3500	444	18	synaptic	synaptic	ADJ
fnp-3500	444	19	plasticity	plasticity	NOUN
fnp-3500	444	20	,	,	PUNCT
fnp-3500	444	21	interaction	interaction	NOUN
fnp-3500	444	22	with	with	ADP
fnp-3500	444	23	neuronal	neuronal	ADJ
fnp-3500	444	24	somata	somata	NOUN
fnp-3500	444	25	and	and	CCONJ
fnp-3500	444	26	phagocytosis	phagocytosis	NOUN
fnp-3500	444	27	.	.	PUNCT
fnp-3500	445	1	thus	thus	ADV
fnp-3500	445	2	,	,	PUNCT
fnp-3500	445	3	a	a	DET
fnp-3500	445	4	compromised	compromise	VERB
fnp-3500	445	5	microglial	microglial	ADJ
fnp-3500	445	6	phagocytic	phagocytic	ADJ
fnp-3500	445	7	removal	removal	NOUN
fnp-3500	445	8	of	of	ADP
fnp-3500	445	9	aβ	aβ	PRON
fnp-3500	445	10	and	and	CCONJ
fnp-3500	445	11	impaired	impair	VERB
fnp-3500	445	12	plaque	plaque	NOUN
fnp-3500	445	13	barrier	barrier	NOUN
fnp-3500	445	14	formation	formation	NOUN
fnp-3500	445	15	upon	upon	SCONJ
fnp-3500	445	16	p2y12	p2y12	NOUN
fnp-3500	445	17	deletion	deletion	NOUN
fnp-3500	445	18	may	may	AUX
fnp-3500	445	19	affect	affect	VERB
fnp-3500	445	20	ad	ad	NOUN
fnp-3500	445	21	progression	progression	NOUN
fnp-3500	445	22	.	.	PUNCT
fnp-3500	446	1	here	here	ADV
fnp-3500	446	2	we	we	PRON
fnp-3500	446	3	analyze	analyze	VERB
fnp-3500	446	4	3d	3d	ADV
fnp-3500	446	5	-	-	PUNCT
fnp-3500	446	6	reconstructed	reconstruct	VERB
fnp-3500	446	7	confocal	confocal	ADJ
fnp-3500	446	8	images	image	NOUN
fnp-3500	446	9	of	of	ADP
fnp-3500	446	10	brain	brain	NOUN
fnp-3500	446	11	tissue	tissue	NOUN
fnp-3500	446	12	from	from	ADP
fnp-3500	446	13	ad	ad	NOUN
fnp-3500	446	14	models	model	NOUN
fnp-3500	446	15	to	to	PART
fnp-3500	446	16	assess	assess	VERB
fnp-3500	446	17	the	the	DET
fnp-3500	446	18	role	role	NOUN
fnp-3500	446	19	of	of	ADP
fnp-3500	446	20	p2y12	p2y12	PROPN
fnp-3500	446	21	in	in	ADP
fnp-3500	446	22	the	the	DET
fnp-3500	446	23	progression	progression	NOUN
fnp-3500	446	24	of	of	ADP
fnp-3500	446	25	aβ	aβ	DET
fnp-3500	446	26	pathology	pathology	NOUN
fnp-3500	446	27	,	,	PUNCT
fnp-3500	446	28	microglia	microglia	ADJ
fnp-3500	446	29	-	-	ADJ
fnp-3500	446	30	plaque	plaque	NOUN
fnp-3500	446	31	interaction	interaction	NOUN
fnp-3500	446	32	and	and	CCONJ
fnp-3500	446	33	inter	inter	ADJ
fnp-3500	446	34	-	-	ADJ
fnp-3500	446	35	cellular	cellular	ADJ
fnp-3500	446	36	interaction	interaction	NOUN
fnp-3500	446	37	between	between	ADP
fnp-3500	446	38	microglial	microglial	ADJ
fnp-3500	446	39	cells	cell	NOUN
fnp-3500	446	40	under	under	ADP
fnp-3500	446	41	neurodegenerative	neurodegenerative	ADJ
fnp-3500	446	42	conditions	condition	NOUN
fnp-3500	446	43	.	.	PUNCT
fnp-3500	447	1	our	our	PRON
fnp-3500	447	2	preliminary	preliminary	ADJ
fnp-3500	447	3	findings	finding	NOUN
fnp-3500	447	4	suggest	suggest	VERB
fnp-3500	447	5	a	a	DET
fnp-3500	447	6	region	region	NOUN
fnp-3500	447	7	-	-	PUNCT
fnp-3500	447	8	dependent	dependent	ADJ
fnp-3500	447	9	modulation	modulation	NOUN
fnp-3500	447	10	of	of	ADP
fnp-3500	447	11	microglial	microglial	ADJ
fnp-3500	447	12	coverage	coverage	NOUN
fnp-3500	447	13	and	and	CCONJ
fnp-3500	447	14	co	co	NOUN
fnp-3500	447	15	-	-	NOUN
fnp-3500	447	16	localization	localization	NOUN
fnp-3500	447	17	with	with	ADP
fnp-3500	447	18	plaques	plaque	NOUN
fnp-3500	447	19	in	in	ADP
fnp-3500	447	20	models	model	NOUN
fnp-3500	447	21	with	with	ADP
fnp-3500	447	22	p2y12	p2y12	NOUN
fnp-3500	447	23	deletion	deletion	NOUN
fnp-3500	447	24	and	and	CCONJ
fnp-3500	447	25	therefore	therefore	ADV
fnp-3500	447	26	that	that	SCONJ
fnp-3500	447	27	this	this	DET
fnp-3500	447	28	receptor	receptor	NOUN
fnp-3500	447	29	may	may	AUX
fnp-3500	447	30	affect	affect	VERB
fnp-3500	447	31	microglial	microglial	ADJ
fnp-3500	447	32	interaction	interaction	NOUN
fnp-3500	447	33	with	with	ADP
fnp-3500	447	34	aβ	aβ	ADP
fnp-3500	447	35	plaques	plaque	NOUN
fnp-3500	447	36	.	.	PUNCT
fnp-3500	448	1	future	future	ADJ
fnp-3500	448	2	studies	study	NOUN
fnp-3500	448	3	investigating	investigate	VERB
fnp-3500	448	4	plaque	plaque	NOUN
fnp-3500	448	5	load	load	NOUN
fnp-3500	448	6	changes	change	NOUN
fnp-3500	448	7	and	and	CCONJ
fnp-3500	448	8	the	the	DET
fnp-3500	448	9	interplay	interplay	NOUN
fnp-3500	448	10	between	between	ADP
fnp-3500	448	11	microglia	microglia	NOUN
fnp-3500	448	12	,	,	PUNCT
fnp-3500	448	13	astrocytes	astrocyte	NOUN
fnp-3500	448	14	and	and	CCONJ
fnp-3500	448	15	neurons	neuron	NOUN
fnp-3500	448	16	will	will	AUX
fnp-3500	448	17	be	be	AUX
fnp-3500	448	18	needed	need	VERB
fnp-3500	448	19	to	to	PART
fnp-3500	448	20	better	well	ADV
fnp-3500	448	21	understand	understand	VERB
fnp-3500	448	22	inter	inter	ADJ
fnp-3500	448	23	-	-	ADJ
fnp-3500	448	24	cellular	cellular	ADJ
fnp-3500	448	25	pathways	pathway	NOUN
fnp-3500	448	26	that	that	PRON
fnp-3500	448	27	contribute	contribute	VERB
fnp-3500	448	28	to	to	ADP
fnp-3500	448	29	p2y12	p2y12	ADV
fnp-3500	448	30	-	-	PUNCT
fnp-3500	448	31	related	relate	VERB
fnp-3500	448	32	effects	effect	NOUN
fnp-3500	448	33	in	in	ADP
fnp-3500	448	34	ad	ad	NOUN
fnp-3500	448	35	pathology	pathology	NOUN
fnp-3500	448	36	.	.	PUNCT
fnp-3500	449	1	copyright	copyright	NOUN
fnp-3500	449	2	:	:	PUNCT
fnp-3500	449	3	©	©	PROPN
fnp-3500	449	4	2021	2021	NUM
fnp-3500	449	5	the	the	DET
fnp-3500	449	6	author(s	author(s	NOUN
fnp-3500	449	7	)	)	PUNCT
fnp-3500	449	8	.	.	PUNCT
fnp-3500	450	1	this	this	PRON
fnp-3500	450	2	is	be	AUX
fnp-3500	450	3	an	an	DET
fnp-3500	450	4	open	open	ADJ
fnp-3500	450	5	access	access	NOUN
fnp-3500	450	6	article	article	NOUN
fnp-3500	450	7	distributed	distribute	VERB
fnp-3500	450	8	under	under	ADP
fnp-3500	450	9	the	the	DET
fnp-3500	450	10	terms	term	NOUN
fnp-3500	450	11	of	of	ADP
fnp-3500	450	12	the	the	DET
fnp-3500	450	13	creative	creative	ADJ
fnp-3500	450	14	commons	common	NOUN
fnp-3500	450	15	attribution	attribution	NOUN
fnp-3500	450	16	4.0	4.0	NUM
fnp-3500	450	17	international	international	ADJ
fnp-3500	450	18	license	license	NOUN
fnp-3500	450	19	(	(	PUNCT
fnp-3500	450	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-3500	450	21	)	)	PUNCT
fnp-3500	450	22	,	,	PUNCT
fnp-3500	450	23	which	which	PRON
fnp-3500	450	24	permits	permit	VERB
fnp-3500	450	25	unrestricted	unrestricted	ADJ
fnp-3500	450	26	use	use	NOUN
fnp-3500	450	27	,	,	PUNCT
fnp-3500	450	28	distribution	distribution	NOUN
fnp-3500	450	29	,	,	PUNCT
fnp-3500	450	30	and	and	CCONJ
fnp-3500	450	31	reproduction	reproduction	NOUN
fnp-3500	450	32	in	in	ADP
fnp-3500	450	33	any	any	DET
fnp-3500	450	34	medium	medium	NOUN
fnp-3500	450	35	,	,	PUNCT
fnp-3500	450	36	provided	provide	VERB
fnp-3500	450	37	the	the	DET
fnp-3500	450	38	original	original	ADJ
fnp-3500	450	39	author	author	NOUN
fnp-3500	450	40	and	and	CCONJ
fnp-3500	450	41	source	source	NOUN
fnp-3500	450	42	are	be	AUX
fnp-3500	450	43	credited	credit	VERB
fnp-3500	450	44	,	,	PUNCT
fnp-3500	450	45	a	a	DET
fnp-3500	450	46	link	link	NOUN
fnp-3500	450	47	to	to	ADP
fnp-3500	450	48	the	the	DET
fnp-3500	450	49	creative	creative	ADJ
fnp-3500	450	50	commons	common	NOUN
fnp-3500	450	51	license	license	NOUN
fnp-3500	450	52	is	be	AUX
fnp-3500	450	53	provided	provide	VERB
fnp-3500	450	54	,	,	PUNCT
fnp-3500	450	55	and	and	CCONJ
fnp-3500	450	56	any	any	DET
fnp-3500	450	57	changes	change	NOUN
fnp-3500	450	58	are	be	AUX
fnp-3500	450	59	indicated	indicate	VERB
fnp-3500	450	60	.	.	PUNCT
fnp-3500	451	1	the	the	DET
fnp-3500	451	2	creative	creative	ADJ
fnp-3500	451	3	commons	common	NOUN
fnp-3500	451	4	public	public	ADJ
fnp-3500	451	5	domain	domain	NOUN
fnp-3500	451	6	dedication	dedication	NOUN
fnp-3500	451	7	waiver	waiver	NOUN
fnp-3500	451	8	(	(	PUNCT
fnp-3500	451	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-3500	451	10	)	)	PUNCT
fnp-3500	451	11	applies	apply	VERB
fnp-3500	451	12	to	to	ADP
fnp-3500	451	13	the	the	DET
fnp-3500	451	14	data	datum	NOUN
fnp-3500	451	15	made	make	VERB
fnp-3500	451	16	available	available	ADJ
fnp-3500	451	17	in	in	ADP
fnp-3500	451	18	this	this	DET
fnp-3500	451	19	article	article	NOUN
fnp-3500	451	20	,	,	PUNCT
fnp-3500	451	21	unless	unless	SCONJ
fnp-3500	451	22	otherwise	otherwise	ADV
fnp-3500	451	23	stated	state	VERB
fnp-3500	451	24	.	.	PUNCT