id sid tid token lemma pos fnp-3682 1 1 63rd 63rd ADJ fnp-3682 1 2 meeting meeting NOUN fnp-3682 1 3 of of ADP fnp-3682 1 4 the the DET fnp-3682 1 5 french french ADJ fnp-3682 1 6 society society NOUN fnp-3682 1 7 of of ADP fnp-3682 1 8 neuropathology neuropathology NOUN fnp-3682 1 9 meeting meeting NOUN fnp-3682 1 10 abstracts abstract NOUN fnp-3682 1 11 , , PUNCT fnp-3682 1 12 december december PROPN fnp-3682 1 13 3rd 3rd NOUN fnp-3682 1 14 . . PUNCT fnp-3682 2 1 2021 2021 NUM fnp-3682 2 2 feel feel VERB fnp-3682 2 3 free free ADJ fnp-3682 2 4 to to PART fnp-3682 2 5 add add VERB fnp-3682 2 6 comments comment NOUN fnp-3682 2 7 by by ADP fnp-3682 2 8 clicking click VERB fnp-3682 2 9 these these DET fnp-3682 2 10 icons icon NOUN fnp-3682 2 11 on on ADP fnp-3682 2 12 the the DET fnp-3682 2 13 sidebar sidebar NOUN fnp-3682 2 14 free free ADJ fnp-3682 2 15 neuropathology neuropathology NOUN fnp-3682 2 16 2:32 2:32 NUM fnp-3682 2 17 ( ( PUNCT fnp-3682 2 18 2021 2021 NUM fnp-3682 2 19 ) ) PUNCT fnp-3682 2 20 meeting meeting NOUN fnp-3682 2 21 abstracts abstract VERB fnp-3682 2 22 63rd 63rd ADJ fnp-3682 2 23 meeting meeting NOUN fnp-3682 2 24 of of ADP fnp-3682 2 25 the the DET fnp-3682 2 26 french french ADJ fnp-3682 2 27 society society NOUN fnp-3682 2 28 of of ADP fnp-3682 2 29 neuropathology neuropathology NOUN fnp-3682 2 30 meeting meeting NOUN fnp-3682 2 31 abstracts abstract NOUN fnp-3682 2 32 december december PROPN fnp-3682 2 33 3rd 3rd NOUN fnp-3682 2 34 , , PUNCT fnp-3682 2 35 2021 2021 NUM fnp-3682 2 36     SPACE fnp-3682 2 37 the the DET fnp-3682 2 38 meeting meeting NOUN fnp-3682 2 39 will will AUX fnp-3682 2 40 take take VERB fnp-3682 2 41 place place NOUN fnp-3682 2 42 online online ADV fnp-3682 2 43 at at ADP fnp-3682 2 44 : : PUNCT fnp-3682 2 45 https://us02web.zoom.us/s/87471519403 https://us02web.zoom.us/s/87471519403 PROPN fnp-3682 2 46 the the DET fnp-3682 2 47 french french ADJ fnp-3682 2 48 society society NOUN fnp-3682 2 49 of of ADP fnp-3682 2 50 neuropathology neuropathology NOUN fnp-3682 2 51 was be AUX fnp-3682 2 52 created create VERB fnp-3682 2 53 in in ADP fnp-3682 2 54 1989 1989 NUM fnp-3682 2 55 , , PUNCT fnp-3682 2 56 succeeding succeed VERB fnp-3682 2 57 the the DET fnp-3682 2 58 french french ADJ fnp-3682 2 59 club club NOUN fnp-3682 2 60 of of ADP fnp-3682 2 61 neuropathology neuropathology NOUN fnp-3682 2 62 set set VERB fnp-3682 2 63 up up ADP fnp-3682 2 64 in in ADP fnp-3682 2 65 1965 1965 NUM fnp-3682 2 66 . . PUNCT fnp-3682 2 67     SPACE fnp-3682 2 68 submitted submit VERB fnp-3682 2 69 : : PUNCT fnp-3682 2 70 19 19 NUM fnp-3682 2 71 november november PROPN fnp-3682 2 72 2021 2021 NUM fnp-3682 2 73 accepted accept VERB fnp-3682 2 74 : : PUNCT fnp-3682 2 75 19 19 NUM fnp-3682 2 76 november november PROPN fnp-3682 2 77 2021 2021 NUM fnp-3682 2 78 published publish VERB fnp-3682 2 79 : : PUNCT fnp-3682 2 80 23 23 NUM fnp-3682 2 81 november november NOUN fnp-3682 2 82 2021 2021 NUM fnp-3682 2 83 https://doi.org/10.17879/freeneuropathology-2021-3682 https://doi.org/10.17879/freeneuropathology-2021-3682 NOUN fnp-3682 2 84 keywords keyword NOUN fnp-3682 2 85 : : PUNCT fnp-3682 2 86 french french ADJ fnp-3682 2 87 society society NOUN fnp-3682 2 88 of of ADP fnp-3682 2 89 neuropathology neuropathology NOUN fnp-3682 2 90 , , PUNCT fnp-3682 2 91 sfnp sfnp PROPN fnp-3682 2 92 , , PUNCT fnp-3682 2 93 meeting meet VERB fnp-3682 2 94 abstracts abstract NOUN fnp-3682 2 95 , , PUNCT fnp-3682 2 96 63rd 63rd ADJ fnp-3682 2 97 meeting meeting NOUN fnp-3682 2 98 dec dec PROPN fnp-3682 2 99 . . PROPN fnp-3682 2 100 2021 2021 NUM fnp-3682 2 101     SPACE fnp-3682 2 102 9:00 9:00 NUM fnp-3682 2 103 introduction introduction NOUN fnp-3682 2 104             SPACE fnp-3682 2 105 short short ADJ fnp-3682 2 106 communications communication NOUN fnp-3682 2 107 9:00 9:00 NUM fnp-3682 2 108 deciphering decipher VERB fnp-3682 2 109 the the DET fnp-3682 2 110 genetic genetic ADJ fnp-3682 2 111 and and CCONJ fnp-3682 2 112 epigenetic epigenetic ADJ fnp-3682 2 113 landscape landscape NOUN fnp-3682 2 114 of of ADP fnp-3682 2 115 pediatric pediatric ADJ fnp-3682 2 116 bithalamic bithalamic ADJ fnp-3682 2 117 tumors tumor NOUN fnp-3682 2 118 9:15 9:15 NUM fnp-3682 2 119 hedgehog hedgehog ADJ fnp-3682 2 120 - - PUNCT fnp-3682 2 121 activated activate VERB fnp-3682 2 122 anterior anterior ADJ fnp-3682 2 123 skull skull PROPN fnp-3682 2 124 base base PROPN fnp-3682 2 125 meningiomas meningiomas PROPN fnp-3682 2 126 overexpress overexpress NOUN fnp-3682 2 127 gab1 gab1 PROPN fnp-3682 2 128 9:30 9:30 NUM fnp-3682 2 129 1p 1p NUM fnp-3682 2 130 deletion deletion NOUN fnp-3682 2 131 and and CCONJ fnp-3682 2 132 fgfr1 fgfr1 NOUN fnp-3682 2 133 alterations alteration NOUN fnp-3682 2 134 as as ADP fnp-3682 2 135 specific specific ADJ fnp-3682 2 136 diagnostic diagnostic ADJ fnp-3682 2 137 tools tool NOUN fnp-3682 2 138 to to PART fnp-3682 2 139 discriminate discriminate VERB fnp-3682 2 140 dlgnt dlgnt PROPN fnp-3682 2 141 from from ADP fnp-3682 2 142 pa pa PROPN fnp-3682 2 143 in in ADP fnp-3682 2 144 medullary medullary ADJ fnp-3682 2 145 location location NOUN fnp-3682 2 146 : : PUNCT fnp-3682 2 147 an an DET fnp-3682 2 148 integrative integrative ADJ fnp-3682 2 149 radiological radiological ADJ fnp-3682 2 150 and and CCONJ fnp-3682 2 151 histomolecular histomolecular ADJ fnp-3682 2 152 series series NOUN fnp-3682 2 153 of of ADP fnp-3682 2 154 28 28 NUM fnp-3682 2 155 cases case NOUN fnp-3682 2 156 9:45 9:45 NUM fnp-3682 2 157 classification classification NOUN fnp-3682 2 158 of of ADP fnp-3682 2 159 pituitary pituitary ADJ fnp-3682 2 160 neuroendocrine neuroendocrine ADJ fnp-3682 2 161 tumors tumor NOUN fnp-3682 2 162 : : PUNCT fnp-3682 2 163 genomic genomic NOUN fnp-3682 2 164 data datum NOUN fnp-3682 2 165 on on ADP fnp-3682 2 166 cell cell NOUN fnp-3682 2 167 lineage lineage NOUN fnp-3682 2 168 10:00 10:00 NUM fnp-3682 2 169 large large ADJ fnp-3682 2 170 brain brain NOUN fnp-3682 2 171 vessel vessel NOUN fnp-3682 2 172 vasculitis vasculitis PROPN fnp-3682 2 173 in in ADP fnp-3682 2 174 immunocompromised immunocompromise VERB fnp-3682 2 175 patients patient NOUN fnp-3682 2 176 10:15 10:15 NUM fnp-3682 2 177 cerebellar cerebellar X fnp-3682 2 178 ataxia ataxia NOUN fnp-3682 2 179 with with ADP fnp-3682 2 180 neuropathy neuropathy ADJ fnp-3682 2 181 and and CCONJ fnp-3682 2 182 vestibular vestibular ADJ fnp-3682 2 183 areflexia areflexia PROPN fnp-3682 2 184 syndrome syndrome NOUN fnp-3682 2 185 ( ( PUNCT fnp-3682 2 186 canvas canvas NOUN fnp-3682 2 187 ): ): PUNCT fnp-3682 2 188 a a DET fnp-3682 2 189 case case NOUN fnp-3682 2 190 report report VERB fnp-3682 2 191 10:30 10:30 NUM fnp-3682 2 192 neuropathological neuropathological ADJ fnp-3682 2 193 and and CCONJ fnp-3682 2 194 amyloid amyloid NOUN fnp-3682 2 195 peptide peptide NOUN fnp-3682 2 196 differences difference NOUN fnp-3682 2 197 between between ADP fnp-3682 2 198 down down ADP fnp-3682 2 199 syndrome syndrome NOUN fnp-3682 2 200 and and CCONJ fnp-3682 2 201 familial familial ADJ fnp-3682 2 202 alzheimer alzheimer PROPN fnp-3682 2 203 ’s ’s PART fnp-3682 2 204 disease disease NOUN fnp-3682 2 205 with with ADP fnp-3682 2 206 duplications duplication NOUN fnp-3682 2 207 and and CCONJ fnp-3682 2 208 missense missense VERB fnp-3682 2 209 mutations mutation NOUN fnp-3682 2 210 in in ADP fnp-3682 2 211 app app PROPN fnp-3682 2 212 gene gene NOUN fnp-3682 3 1 10:45 10:45 NUM fnp-3682 3 2 characterization characterization NOUN fnp-3682 3 3 of of ADP fnp-3682 3 4 the the DET fnp-3682 3 5 endolysosomal endolysosomal ADJ fnp-3682 3 6 compartment compartment NOUN fnp-3682 3 7 of of ADP fnp-3682 3 8 noradrenergic noradrenergic ADJ fnp-3682 3 9 neurons neuron NOUN fnp-3682 3 10 of of ADP fnp-3682 3 11 the the DET fnp-3682 3 12 locus locus ADJ fnp-3682 3 13 cœruleus cœruleus NOUN fnp-3682 3 14 in in ADP fnp-3682 3 15 neurodegenerative neurodegenerative ADJ fnp-3682 3 16 diseases disease NOUN fnp-3682 3 17 11:00 11:00 NUM fnp-3682 3 18 neuropathology neuropathology NOUN fnp-3682 3 19 analysis analysis NOUN fnp-3682 3 20 as as ADP fnp-3682 3 21 a a DET fnp-3682 3 22 precious precious ADJ fnp-3682 3 23 tool tool NOUN fnp-3682 3 24 to to PART fnp-3682 3 25 ascertain ascertain VERB fnp-3682 3 26 the the DET fnp-3682 3 27 pathogenicity pathogenicity NOUN fnp-3682 3 28 of of ADP fnp-3682 3 29 nearsplice nearsplice NOUN fnp-3682 3 30 / / SYM fnp-3682 3 31 intronic intronic ADJ fnp-3682 3 32 variants variant NOUN fnp-3682 3 33 in in ADP fnp-3682 3 34 amyotrophic amyotrophic ADJ fnp-3682 3 35 lateral lateral ADJ fnp-3682 3 36 sclerosis sclerosis NOUN fnp-3682 3 37 : : PUNCT fnp-3682 3 38 example example NOUN fnp-3682 3 39 of of ADP fnp-3682 3 40 a a DET fnp-3682 3 41 sod1 sod1 ADJ fnp-3682 3 42 nearsplice nearsplice NOUN fnp-3682 3 43 / / SYM fnp-3682 3 44 intronic intronic ADJ fnp-3682 3 45 mutation mutation NOUN fnp-3682 3 46             SPACE fnp-3682 3 47 conferences conference VERB fnp-3682 3 48 11:15 11:15 NUM fnp-3682 3 49 implication implication NOUN fnp-3682 3 50 of of ADP fnp-3682 3 51 microglial microglial ADJ fnp-3682 3 52 cells cell NOUN fnp-3682 3 53 and and CCONJ fnp-3682 3 54 peripheral peripheral ADJ fnp-3682 3 55 macrophages macrophage NOUN fnp-3682 3 56 in in ADP fnp-3682 3 57 amyotrophic amyotrophic ADJ fnp-3682 3 58 lateral lateral ADJ fnp-3682 3 59 sclerosis sclerosis NOUN fnp-3682 3 60 ( ( PUNCT fnp-3682 3 61 als als NOUN fnp-3682 3 62 ) ) PUNCT fnp-3682 3 63 14:15 14:15 NUM fnp-3682 3 64 the the DET fnp-3682 3 65 neuro neuro PROPN fnp-3682 3 66 - - PUNCT fnp-3682 3 67 ceb ceb PROPN fnp-3682 3 68 brainbank brainbank NOUN fnp-3682 3 69 : : PUNCT fnp-3682 3 70 a a DET fnp-3682 3 71 brief brief ADJ fnp-3682 3 72 history history NOUN fnp-3682 3 73 ( ( PUNCT fnp-3682 3 74 15 15 NUM fnp-3682 3 75 years year NOUN fnp-3682 3 76 ! ! PUNCT fnp-3682 3 77 ) ) PUNCT fnp-3682 3 78 of of ADP fnp-3682 3 79 neuropathology neuropathology NOUN fnp-3682 3 80 14:30 14:30 NUM fnp-3682 3 81 human human ADJ fnp-3682 3 82 brain brain NOUN fnp-3682 3 83 imaging imaging NOUN fnp-3682 3 84 with with ADP fnp-3682 3 85 stochastic stochastic ADJ fnp-3682 3 86 optical optical ADJ fnp-3682 3 87 reconstruction reconstruction NOUN fnp-3682 3 88 microscopy microscopy NOUN fnp-3682 3 89 ( ( PUNCT fnp-3682 3 90 storm storm NOUN fnp-3682 3 91 ) ) PUNCT fnp-3682 3 92 14:45 14:45 NUM fnp-3682 3 93 ai ai AUX fnp-3682 3 94 applied apply VERB fnp-3682 3 95 in in ADP fnp-3682 3 96 neuropathology neuropathology NOUN fnp-3682 3 97 : : PUNCT fnp-3682 3 98 automated automate VERB fnp-3682 3 99 detection detection NOUN fnp-3682 3 100 of of ADP fnp-3682 3 101 intraepidermal intraepidermal ADJ fnp-3682 3 102 nerve nerve NOUN fnp-3682 3 103 fibers fiber NOUN fnp-3682 3 104 for for ADP fnp-3682 3 105 the the DET fnp-3682 3 106 diagnosis diagnosis NOUN fnp-3682 3 107 of of ADP fnp-3682 3 108 small small ADJ fnp-3682 3 109 - - PUNCT fnp-3682 3 110 fiber fiber NOUN fnp-3682 3 111 neuropathies neuropathie VERB fnp-3682 3 112 15:00 15:00 NUM fnp-3682 3 113 histological histological ADJ fnp-3682 3 114 description description NOUN fnp-3682 3 115 of of ADP fnp-3682 3 116 myopathy myopathy ADJ fnp-3682 3 117 related relate VERB fnp-3682 3 118 to to ADP fnp-3682 3 119 chronic chronic ADJ fnp-3682 3 120 graft graft NOUN fnp-3682 3 121 versus versus ADP fnp-3682 3 122 host host NOUN fnp-3682 3 123 disease disease NOUN fnp-3682 3 124 and and CCONJ fnp-3682 3 125 characterization characterization NOUN fnp-3682 3 126 of of ADP fnp-3682 3 127 inflammatory inflammatory ADJ fnp-3682 3 128 infiltrate infiltrate NOUN fnp-3682 3 129 by by ADP fnp-3682 3 130 imaging image VERB fnp-3682 3 131 mass mass PROPN fnp-3682 3 132 cytometry cytometry NOUN fnp-3682 3 133 15:15 15:15 NUM fnp-3682 3 134 highlighting highlighting NOUN fnp-3682 3 135 autophagy autophagy NOUN fnp-3682 3 136 in in ADP fnp-3682 3 137 a a DET fnp-3682 3 138 fatal fatal ADJ fnp-3682 3 139 case case NOUN fnp-3682 3 140 of of ADP fnp-3682 3 141 pompe pompe PROPN fnp-3682 3 142 ’s ’s PART fnp-3682 3 143 disease disease NOUN fnp-3682 3 144 15:30 15:30 NUM fnp-3682 3 145 diagnosis diagnosis NOUN fnp-3682 3 146 and and CCONJ fnp-3682 3 147 classification classification NOUN fnp-3682 3 148 of of ADP fnp-3682 3 149 peripheral peripheral ADJ fnp-3682 3 150 nerve nerve NOUN fnp-3682 3 151 vasculitis vasculitis NOUN fnp-3682 3 152 : : PUNCT fnp-3682 3 153 attempt attempt VERB fnp-3682 3 154 at at ADP fnp-3682 3 155 simplification simplification NOUN fnp-3682 3 156 bases basis NOUN fnp-3682 3 157 on on ADP fnp-3682 3 158 a a DET fnp-3682 3 159 retrospective retrospective ADJ fnp-3682 3 160 study study NOUN fnp-3682 3 161 at at ADP fnp-3682 3 162 limoges limoges PROPN fnp-3682 3 163 university university NOUN fnp-3682 3 164 hospital hospital NOUN fnp-3682 3 165 between between ADP fnp-3682 3 166 2014 2014 NUM fnp-3682 3 167 and and CCONJ fnp-3682 3 168 2020 2020 NUM fnp-3682 3 169 15:45 15:45 NUM fnp-3682 3 170 experimental experimental ADJ fnp-3682 3 171 evaluation evaluation NOUN fnp-3682 3 172 of of ADP fnp-3682 3 173 myosuppressive myosuppressive ADJ fnp-3682 3 174 effects effect NOUN fnp-3682 3 175 of of ADP fnp-3682 3 176 ifn ifn PROPN fnp-3682 3 177 - - PUNCT fnp-3682 3 178 gamma gamma NOUN fnp-3682 3 179             SPACE fnp-3682 3 180 general general PROPN fnp-3682 3 181 assembly assembly NOUN fnp-3682 3 182 ( ( PUNCT fnp-3682 3 183 members member NOUN fnp-3682 3 184 only only ADV fnp-3682 3 185 ) ) PUNCT fnp-3682 3 186 short short ADJ fnp-3682 3 187 communications communication NOUN fnp-3682 3 188 : : PUNCT fnp-3682 3 189     SPACE fnp-3682 3 190 free free ADJ fnp-3682 3 191 neuropathol neuropathol NOUN fnp-3682 3 192 2:32:3 2:32:3 NUM fnp-3682 3 193 deciphering decipher VERB fnp-3682 3 194 the the DET fnp-3682 3 195 genetic genetic ADJ fnp-3682 3 196 and and CCONJ fnp-3682 3 197 epigenetic epigenetic ADJ fnp-3682 3 198 landscape landscape NOUN fnp-3682 3 199 of of ADP fnp-3682 3 200 pediatric pediatric ADJ fnp-3682 3 201 bithalamic bithalamic NOUN fnp-3682 3 202 tumors tumor NOUN fnp-3682 3 203 arnault arnault VERB fnp-3682 3 204 tauziède tauziède VERB fnp-3682 3 205 - - PUNCT fnp-3682 3 206 espariat1 espariat1 NOUN fnp-3682 3 207 , , PUNCT fnp-3682 3 208 marie marie PROPN fnp-3682 3 209 - - PUNCT fnp-3682 3 210 anne anne PROPN fnp-3682 3 211 debily2,3 debily2,3 PROPN fnp-3682 3 212 , , PUNCT fnp-3682 3 213 david david PROPN fnp-3682 3 214 castel2,4 castel2,4 PROPN fnp-3682 3 215 , , PUNCT fnp-3682 3 216 jacques jacques PROPN fnp-3682 3 217 grill2,4 grill2,4 PROPN fnp-3682 3 218 , , PUNCT fnp-3682 3 219 stéphanie stéphanie NOUN fnp-3682 3 220 puget5 puget5 PROPN fnp-3682 3 221 , , PUNCT fnp-3682 3 222 alexandre alexandre PROPN fnp-3682 3 223 roux6 roux6 PROPN fnp-3682 3 224 , , PUNCT fnp-3682 3 225 raphaël raphaël NOUN fnp-3682 3 226 saffroy7 saffroy7 PROPN fnp-3682 3 227 , , PUNCT fnp-3682 3 228 guillaume guillaume PROPN fnp-3682 3 229 gauchotte8 gauchotte8 PROPN fnp-3682 3 230 , , PUNCT fnp-3682 3 231 ellen ellen PROPN fnp-3682 3 232 wahler1 wahler1 PROPN fnp-3682 3 233 , , PUNCT fnp-3682 3 234 lauren lauren PROPN fnp-3682 3 235 hasty1 hasty1 PROPN fnp-3682 3 236 , , PUNCT fnp-3682 3 237 fabrice fabrice PROPN fnp-3682 3 238 chrétien1 chrétien1 PROPN fnp-3682 3 239 , , PUNCT fnp-3682 3 240 emmanuèle emmanuèle VERB fnp-3682 3 241 lechapt1 lechapt1 ADJ fnp-3682 3 242 , , PUNCT fnp-3682 3 243 volodia volodia NOUN fnp-3682 3 244 dangouloff dangouloff NOUN fnp-3682 3 245 - - PUNCT fnp-3682 3 246 ros9 ros9 PROPN fnp-3682 3 247 , , PUNCT fnp-3682 3 248 nathalie nathalie PROPN fnp-3682 3 249 boddaert9 boddaert9 PROPN fnp-3682 3 250 , , PUNCT fnp-3682 3 251 philipp philipp PROPN fnp-3682 3 252 sievers10,11 sievers10,11 PROPN fnp-3682 3 253 # # PART fnp-3682 3 254 , , PUNCT fnp-3682 3 255 pascale pascale PROPN fnp-3682 3 256 varlet1 varlet1 NOUN fnp-3682 3 257 # # NOUN fnp-3682 3 258 1 1 NUM fnp-3682 3 259 department department NOUN fnp-3682 3 260 of of ADP fnp-3682 3 261 neuropathology neuropathology NOUN fnp-3682 3 262 , , PUNCT fnp-3682 3 263 ghu ghu PROPN fnp-3682 3 264 paris paris PROPN fnp-3682 3 265 - - PUNCT fnp-3682 3 266 psychiatrie psychiatrie PROPN fnp-3682 3 267 et et NOUN fnp-3682 3 268 neurosciences neuroscience NOUN fnp-3682 3 269 , , PUNCT fnp-3682 3 270 sainte sainte PROPN fnp-3682 3 271 - - PUNCT fnp-3682 3 272 anne anne PROPN fnp-3682 3 273 hospital hospital PROPN fnp-3682 3 274 , , PUNCT fnp-3682 3 275 75014 75014 NUM fnp-3682 3 276 paris paris PROPN fnp-3682 3 277 , , PUNCT fnp-3682 3 278 france france PROPN fnp-3682 3 279 2 2 NUM fnp-3682 3 280 u981 u981 PROPN fnp-3682 3 281 , , PUNCT fnp-3682 3 282 molecular molecular ADJ fnp-3682 3 283 predictors predictor NOUN fnp-3682 3 284 and and CCONJ fnp-3682 3 285 new new ADJ fnp-3682 3 286 targets target NOUN fnp-3682 3 287 in in ADP fnp-3682 3 288 oncology oncology NOUN fnp-3682 3 289 , , PUNCT fnp-3682 3 290 inserm inserm NOUN fnp-3682 3 291 , , PUNCT fnp-3682 3 292 gustave gustave NOUN fnp-3682 3 293 roussy roussy NOUN fnp-3682 3 294 , , PUNCT fnp-3682 3 295 université université PROPN fnp-3682 3 296 paris paris PROPN fnp-3682 3 297 - - PUNCT fnp-3682 3 298 saclay saclay NOUN fnp-3682 3 299 , , PUNCT fnp-3682 3 300 94805 94805 NUM fnp-3682 3 301 villejuif villejuif NOUN fnp-3682 3 302 , , PUNCT fnp-3682 3 303 france france PROPN fnp-3682 3 304 3 3 NUM fnp-3682 3 305 université université NOUN fnp-3682 3 306 evry evry PROPN fnp-3682 3 307 , , PUNCT fnp-3682 3 308 université université PROPN fnp-3682 3 309 paris paris PROPN fnp-3682 3 310 - - PUNCT fnp-3682 3 311 saclay saclay NOUN fnp-3682 3 312 , , PUNCT fnp-3682 3 313 91000 91000 NUM fnp-3682 3 314 evry evry VERB fnp-3682 3 315 , , PUNCT fnp-3682 3 316 france france PROPN fnp-3682 3 317 4 4 NUM fnp-3682 3 318 department department NOUN fnp-3682 3 319 of of ADP fnp-3682 3 320 pediatric pediatric ADJ fnp-3682 3 321 oncology oncology NOUN fnp-3682 3 322 , , PUNCT fnp-3682 3 323 gustave gustave NOUN fnp-3682 3 324 roussy roussy NOUN fnp-3682 3 325 , , PUNCT fnp-3682 3 326 université université PROPN fnp-3682 3 327 paris paris PROPN fnp-3682 3 328 - - PUNCT fnp-3682 3 329 saclay saclay NOUN fnp-3682 3 330 , , PUNCT fnp-3682 3 331 94805 94805 NUM fnp-3682 3 332 villejuif villejuif NOUN fnp-3682 3 333 , , PUNCT fnp-3682 3 334 france france PROPN fnp-3682 3 335 5 5 NUM fnp-3682 3 336 department department NOUN fnp-3682 3 337 of of ADP fnp-3682 3 338 pediatric pediatric ADJ fnp-3682 3 339 neurosurgery neurosurgery NOUN fnp-3682 3 340 , , PUNCT fnp-3682 3 341 necker necker NOUN fnp-3682 3 342 hospital hospital NOUN fnp-3682 3 343 , , PUNCT fnp-3682 3 344 aphp aphp VERB fnp-3682 3 345 , , PUNCT fnp-3682 3 346 université université PROPN fnp-3682 3 347 paris paris PROPN fnp-3682 3 348 descartes descartes PROPN fnp-3682 3 349 , , PUNCT fnp-3682 3 350 sorbonne sorbonne PROPN fnp-3682 3 351 paris paris PROPN fnp-3682 3 352 cite cite VERB fnp-3682 3 353 , , PUNCT fnp-3682 3 354 75015 75015 NUM fnp-3682 3 355 paris paris PROPN fnp-3682 3 356 , , PUNCT fnp-3682 3 357 france france PROPN fnp-3682 3 358 6 6 NUM fnp-3682 3 359 department department NOUN fnp-3682 3 360 of of ADP fnp-3682 3 361 neurosurgery neurosurgery NOUN fnp-3682 3 362 , , PUNCT fnp-3682 3 363 ghu ghu PROPN fnp-3682 3 364 paris paris PROPN fnp-3682 3 365 - - PUNCT fnp-3682 3 366 psychiatrie psychiatrie PROPN fnp-3682 3 367 et et NOUN fnp-3682 3 368 neurosciences neuroscience NOUN fnp-3682 3 369 , , PUNCT fnp-3682 3 370 sainte sainte PROPN fnp-3682 3 371 - - PUNCT fnp-3682 3 372 anne anne PROPN fnp-3682 3 373 hospital hospital PROPN fnp-3682 3 374 , , PUNCT fnp-3682 3 375 75014 75014 NUM fnp-3682 3 376 paris paris PROPN fnp-3682 3 377 , , PUNCT fnp-3682 3 378 france france PROPN fnp-3682 3 379 7 7 NUM fnp-3682 3 380 department department PROPN fnp-3682 3 381 of of ADP fnp-3682 3 382 biochemistry biochemistry NOUN fnp-3682 3 383 and and CCONJ fnp-3682 3 384 oncogenetic oncogenetic NOUN fnp-3682 3 385 , , PUNCT fnp-3682 3 386 paul paul PROPN fnp-3682 3 387 brousse brousse PROPN fnp-3682 3 388 hospital hospital PROPN fnp-3682 3 389 , , PUNCT fnp-3682 3 390 94804 94804 NUM fnp-3682 3 391 villejuif villejuif NOUN fnp-3682 3 392 , , PUNCT fnp-3682 3 393 france france PROPN fnp-3682 3 394 8 8 NUM fnp-3682 3 395 department department NOUN fnp-3682 3 396 of of ADP fnp-3682 3 397 pathology pathology PROPN fnp-3682 3 398 , , PUNCT fnp-3682 3 399 chru chru PROPN fnp-3682 3 400 , , PUNCT fnp-3682 3 401 nancy nancy PROPN fnp-3682 3 402 , , PUNCT fnp-3682 3 403 france france PROPN fnp-3682 3 404 9 9 NUM fnp-3682 3 405 pediatric pediatric ADJ fnp-3682 3 406 radiology radiology NOUN fnp-3682 3 407 department department NOUN fnp-3682 3 408 , , PUNCT fnp-3682 3 409 hôpital hôpital PROPN fnp-3682 3 410 necker necker PROPN fnp-3682 3 411 enfants enfants X fnp-3682 3 412 malades malades PROPN fnp-3682 3 413 , , PUNCT fnp-3682 3 414 ap ap PROPN fnp-3682 3 415 - - PUNCT fnp-3682 3 416 hp hp PROPN fnp-3682 3 417 , , PUNCT fnp-3682 3 418 university university PROPN fnp-3682 3 419 de de X fnp-3682 3 420 paris paris PROPN fnp-3682 3 421 , , PUNCT fnp-3682 3 422 france france PROPN fnp-3682 3 423 10 10 NUM fnp-3682 3 424 department department NOUN fnp-3682 3 425 of of ADP fnp-3682 3 426 neuropathology neuropathology NOUN fnp-3682 3 427 , , PUNCT fnp-3682 3 428 institute institute PROPN fnp-3682 3 429 of of ADP fnp-3682 3 430 pathology pathology PROPN fnp-3682 3 431 , , PUNCT fnp-3682 3 432 university university NOUN fnp-3682 3 433 hospital hospital NOUN fnp-3682 3 434 heidelberg heidelberg PROPN fnp-3682 3 435 , , PUNCT fnp-3682 3 436 heidelberg heidelberg PROPN fnp-3682 3 437 , , PUNCT fnp-3682 3 438 germany germany PROPN fnp-3682 3 439 11 11 NUM fnp-3682 3 440 clinical clinical ADJ fnp-3682 3 441 cooperation cooperation NOUN fnp-3682 3 442 unit unit NOUN fnp-3682 3 443 neuropathology neuropathology NOUN fnp-3682 3 444 , , PUNCT fnp-3682 3 445 german german ADJ fnp-3682 3 446 consortium consortium NOUN fnp-3682 3 447 for for ADP fnp-3682 3 448 translational translational ADJ fnp-3682 3 449 cancer cancer NOUN fnp-3682 3 450 research research NOUN fnp-3682 3 451 ( ( PUNCT fnp-3682 3 452 dktk dktk NOUN fnp-3682 3 453 ) ) PUNCT fnp-3682 3 454 , , PUNCT fnp-3682 3 455 german german ADJ fnp-3682 3 456 cancer cancer NOUN fnp-3682 3 457 research research NOUN fnp-3682 3 458 center center PROPN fnp-3682 3 459 dkfz dkfz NOUN fnp-3682 3 460 , , PUNCT fnp-3682 3 461 heidelberg heidelberg PROPN fnp-3682 3 462 , , PUNCT fnp-3682 3 463 germany germany PROPN fnp-3682 3 464 # # PROPN fnp-3682 3 465 these these DET fnp-3682 3 466 authors author NOUN fnp-3682 3 467 contributed contribute VERB fnp-3682 3 468 equally equally ADV fnp-3682 3 469 to to ADP fnp-3682 3 470 this this DET fnp-3682 3 471 work work NOUN fnp-3682 3 472 . . PUNCT fnp-3682 4 1 over over ADP fnp-3682 4 2 the the DET fnp-3682 4 3 past past ADJ fnp-3682 4 4 several several ADJ fnp-3682 4 5 years year NOUN fnp-3682 4 6 , , PUNCT fnp-3682 4 7 based base VERB fnp-3682 4 8 on on ADP fnp-3682 4 9 the the DET fnp-3682 4 10 results result NOUN fnp-3682 4 11 of of ADP fnp-3682 4 12 the the DET fnp-3682 4 13 literature literature NOUN fnp-3682 4 14 : : PUNCT fnp-3682 4 15 1 1 X fnp-3682 4 16 ) ) PUNCT fnp-3682 4 17 diffuse diffuse VERB fnp-3682 4 18 midline midline NOUN fnp-3682 4 19 gliomas glioma NOUN fnp-3682 4 20 ( ( PUNCT fnp-3682 4 21 dmg dmg NOUN fnp-3682 4 22 ) ) PUNCT fnp-3682 4 23 were be AUX fnp-3682 4 24 defined define VERB fnp-3682 4 25 as as ADP fnp-3682 4 26 a a DET fnp-3682 4 27 new new ADJ fnp-3682 4 28 tumoral tumoral ADJ fnp-3682 4 29 type type NOUN fnp-3682 4 30 in in ADP fnp-3682 4 31 the the DET fnp-3682 4 32 2016 2016 NUM fnp-3682 4 33 who who PRON fnp-3682 4 34 classification classification VERB fnp-3682 4 35 , , PUNCT fnp-3682 4 36 and and CCONJ fnp-3682 4 37 2 2 X fnp-3682 4 38 ) ) PUNCT fnp-3682 4 39 four four NUM fnp-3682 4 40 different different ADJ fnp-3682 4 41 subtypes subtype NOUN fnp-3682 4 42 are be AUX fnp-3682 4 43 now now ADV fnp-3682 4 44 defined define VERB fnp-3682 4 45 depending depend VERB fnp-3682 4 46 on on ADP fnp-3682 4 47 their their PRON fnp-3682 4 48 molecular molecular ADJ fnp-3682 4 49 characteristics characteristic NOUN fnp-3682 4 50 , , PUNCT fnp-3682 4 51 and/or and/or CCONJ fnp-3682 4 52 locations location NOUN fnp-3682 4 53 : : PUNCT fnp-3682 4 54 dmg dmg NOUN fnp-3682 4 55 h3.3 h3.3 NOUN fnp-3682 4 56 k27 k27 NOUN fnp-3682 4 57 – – PUNCT fnp-3682 4 58 mutant mutant NOUN fnp-3682 4 59 , , PUNCT fnp-3682 4 60 dmg dmg VERB fnp-3682 4 61 h3.1 h3.1 ADJ fnp-3682 4 62 or or CCONJ fnp-3682 4 63 h3.2 h3.2 NOUN fnp-3682 4 64 k27 k27 NOUN fnp-3682 4 65 – – PUNCT fnp-3682 4 66 mutant mutant NOUN fnp-3682 4 67 , , PUNCT fnp-3682 4 68 dmg dmg PROPN fnp-3682 4 69 h3 h3 NOUN fnp-3682 4 70 - - PUNCT fnp-3682 4 71 wildtype wildtype NOUN fnp-3682 4 72 with with ADP fnp-3682 4 73 ezhip ezhip NOUN fnp-3682 4 74 overexpression overexpression NOUN fnp-3682 4 75 , , PUNCT fnp-3682 4 76 and and CCONJ fnp-3682 4 77 dmg dmg VERB fnp-3682 4 78 egfr egfr NOUN fnp-3682 4 79 - - PUNCT fnp-3682 4 80 altered alter VERB fnp-3682 4 81 . . PUNCT fnp-3682 5 1 however however ADV fnp-3682 5 2 , , PUNCT fnp-3682 5 3 in in ADP fnp-3682 5 4 this this DET fnp-3682 5 5 rapidly rapidly ADV fnp-3682 5 6 evolving evolve VERB fnp-3682 5 7 field field NOUN fnp-3682 5 8 , , PUNCT fnp-3682 5 9 a a DET fnp-3682 5 10 more more ADV fnp-3682 5 11 comprehensive comprehensive ADJ fnp-3682 5 12 analysis analysis NOUN fnp-3682 5 13 of of ADP fnp-3682 5 14 pediatric pediatric ADJ fnp-3682 5 15 bithalamic bithalamic ADJ fnp-3682 5 16 gliomas glioma NOUN fnp-3682 5 17 is be AUX fnp-3682 5 18 needed need VERB fnp-3682 5 19 . . PUNCT fnp-3682 6 1 we we PRON fnp-3682 6 2 investigated investigate VERB fnp-3682 6 3 retrospectively retrospectively ADV fnp-3682 6 4 data datum NOUN fnp-3682 6 5 from from ADP fnp-3682 6 6 19 19 NUM fnp-3682 6 7 pediatric pediatric ADJ fnp-3682 6 8 bithalamic bithalamic NOUN fnp-3682 6 9 gliomas glioma NOUN fnp-3682 6 10 , , PUNCT fnp-3682 6 11 confirmed confirm VERB fnp-3682 6 12 by by ADP fnp-3682 6 13 a a DET fnp-3682 6 14 central central ADJ fnp-3682 6 15 radiological radiological ADJ fnp-3682 6 16 review review NOUN fnp-3682 6 17 . . PUNCT fnp-3682 7 1 we we PRON fnp-3682 7 2 also also ADV fnp-3682 7 3 performed perform VERB fnp-3682 7 4 a a DET fnp-3682 7 5 comprehensive comprehensive ADJ fnp-3682 7 6 clinical clinical NOUN fnp-3682 7 7 , , PUNCT fnp-3682 7 8 histopathological histopathological ADJ fnp-3682 7 9 and and CCONJ fnp-3682 7 10 molecular molecular ADJ fnp-3682 7 11 evaluation evaluation NOUN fnp-3682 7 12 , , PUNCT fnp-3682 7 13 as as ADV fnp-3682 7 14 well well ADV fnp-3682 7 15 as as ADP fnp-3682 7 16 dna dna PROPN fnp-3682 7 17 methylation methylation NOUN fnp-3682 7 18 profiling profiling NOUN fnp-3682 7 19 . . PUNCT fnp-3682 7 20         SPACE fnp-3682 8 1 free free ADJ fnp-3682 8 2 neuropathol neuropathol NOUN fnp-3682 8 3 2:32:4 2:32:4 NUM fnp-3682 8 4 hedgehog hedgehog ADJ fnp-3682 8 5 - - PUNCT fnp-3682 8 6 activated activate VERB fnp-3682 8 7 anterior anterior ADJ fnp-3682 8 8 skull skull PROPN fnp-3682 8 9 base base PROPN fnp-3682 8 10 meningiomas meningiomas PROPN fnp-3682 8 11 overexpress overexpress PROPN fnp-3682 8 12 gab1 gab1 PROPN fnp-3682 8 13 julien julien PROPN fnp-3682 8 14 boetto1,2 boetto1,2 PROPN fnp-3682 8 15 , , PUNCT fnp-3682 8 16 julie julie PROPN fnp-3682 8 17 lerond2,3 lerond2,3 PROPN fnp-3682 8 18 , , PUNCT fnp-3682 8 19 matthieu matthieu PROPN fnp-3682 8 20 peyre2,4,5 peyre2,4,5 PROPN fnp-3682 8 21 , , PUNCT fnp-3682 8 22 suzanne suzanne PROPN fnp-3682 8 23 tran5,6 tran5,6 PROPN fnp-3682 8 24 , , PUNCT fnp-3682 8 25 pauline pauline PROPN fnp-3682 8 26 marijon2,4 marijon2,4 PROPN fnp-3682 8 27 , , PUNCT fnp-3682 8 28 michel michel PROPN fnp-3682 8 29 kalamarides2,4,5 kalamarides2,4,5 PROPN fnp-3682 8 30 , , PUNCT fnp-3682 8 31 franck franck X fnp-3682 8 32 bielle2,3,5,6,7 bielle2,3,5,6,7 PROPN fnp-3682 8 33 1 1 NUM fnp-3682 8 34 department department NOUN fnp-3682 8 35 of of ADP fnp-3682 8 36 neurosurgery neurosurgery NOUN fnp-3682 8 37 , , PUNCT fnp-3682 8 38 gui gui NOUN fnp-3682 8 39 de de PROPN fnp-3682 8 40 chauliac chauliac PROPN fnp-3682 8 41 hospital hospital PROPN fnp-3682 8 42 , , PUNCT fnp-3682 8 43 montpellier montpellier PROPN fnp-3682 8 44 university university PROPN fnp-3682 8 45 hospital hospital NOUN fnp-3682 8 46 center center NOUN fnp-3682 8 47 , , PUNCT fnp-3682 8 48 montpellier montpellier NOUN fnp-3682 8 49 , , PUNCT fnp-3682 8 50 france france PROPN fnp-3682 8 51 2 2 NUM fnp-3682 8 52 icm icm PROPN fnp-3682 8 53 inserm inserm NOUN fnp-3682 8 54 u1127 u1127 PROPN fnp-3682 8 55 cnrs cnrs VERB fnp-3682 8 56 umr umr ADP fnp-3682 8 57 7225 7225 NUM fnp-3682 8 58 , , PUNCT fnp-3682 8 59 paris paris PROPN fnp-3682 8 60 brain brain PROPN fnp-3682 8 61 institute institute PROPN fnp-3682 8 62 , , PUNCT fnp-3682 8 63 paris paris PROPN fnp-3682 8 64 , , PUNCT fnp-3682 8 65 france france PROPN fnp-3682 8 66 3 3 NUM fnp-3682 8 67 siric siric NOUN fnp-3682 8 68 curamus curamus NOUN fnp-3682 8 69 ( ( PUNCT fnp-3682 8 70 cancer cancer NOUN fnp-3682 8 71 united united PROPN fnp-3682 8 72 research research PROPN fnp-3682 8 73 associating associate VERB fnp-3682 8 74 medicine medicine NOUN fnp-3682 8 75 , , PUNCT fnp-3682 8 76 university university NOUN fnp-3682 8 77 & & CCONJ fnp-3682 8 78 society society NOUN fnp-3682 8 79 ) ) PUNCT fnp-3682 8 80 site site NOUN fnp-3682 8 81 de de X fnp-3682 8 82 recherche recherche X fnp-3682 8 83 intégrée intégrée VERB fnp-3682 8 84 sur sur PROPN fnp-3682 8 85 le le X fnp-3682 8 86 cancer cancer NOUN fnp-3682 8 87 iuc iuc NOUN fnp-3682 8 88 aphp.6 aphp.6 PROPN fnp-3682 8 89 sorbonne sorbonne PROPN fnp-3682 8 90 université université PROPN fnp-3682 8 91 , , PUNCT fnp-3682 8 92 paris paris PROPN fnp-3682 8 93 , , PUNCT fnp-3682 8 94 france france PROPN fnp-3682 8 95 4 4 NUM fnp-3682 8 96 department department NOUN fnp-3682 8 97 of of ADP fnp-3682 8 98 neurosurgery neurosurgery NOUN fnp-3682 8 99 , , PUNCT fnp-3682 8 100 ap ap PROPN fnp-3682 8 101 - - PUNCT fnp-3682 8 102 hp hp PROPN fnp-3682 8 103 , , PUNCT fnp-3682 8 104 hôpital hôpital ADJ fnp-3682 8 105 pitié pitié PROPN fnp-3682 8 106 - - PUNCT fnp-3682 8 107 salpêtrière salpêtrière PROPN fnp-3682 8 108 , , PUNCT fnp-3682 8 109 paris paris PROPN fnp-3682 8 110 , , PUNCT fnp-3682 8 111 france france PROPN fnp-3682 8 112 5 5 NUM fnp-3682 8 113 sorbonne sorbonne PROPN fnp-3682 8 114 université université PROPN fnp-3682 8 115 , , PUNCT fnp-3682 8 116 upmc upmc PROPN fnp-3682 8 117 université université PROPN fnp-3682 8 118 paris paris PROPN fnp-3682 8 119 06 06 NUM fnp-3682 8 120 , , PUNCT fnp-3682 8 121 paris paris PROPN fnp-3682 8 122 , , PUNCT fnp-3682 8 123 france france PROPN fnp-3682 8 124 6 6 NUM fnp-3682 8 125 department department NOUN fnp-3682 8 126 of of ADP fnp-3682 8 127 neuropathology neuropathology NOUN fnp-3682 8 128 , , PUNCT fnp-3682 8 129 ap ap PROPN fnp-3682 8 130 - - PUNCT fnp-3682 8 131 hp hp PROPN fnp-3682 8 132 , , PUNCT fnp-3682 8 133 hôpital hôpital PROPN fnp-3682 8 134 pitié pitié PROPN fnp-3682 8 135 salpêtrière salpêtrière PROPN fnp-3682 8 136 , , PUNCT fnp-3682 8 137 paris paris PROPN fnp-3682 8 138 , , PUNCT fnp-3682 8 139 france france PROPN fnp-3682 8 140 7 7 NUM fnp-3682 8 141 onconeurotek onconeurotek NOUN fnp-3682 8 142 , , PUNCT fnp-3682 8 143 ap ap PROPN fnp-3682 8 144 - - PUNCT fnp-3682 8 145 hp hp PROPN fnp-3682 8 146 , , PUNCT fnp-3682 8 147 hôpital hôpital ADJ fnp-3682 8 148 pitié pitié PROPN fnp-3682 8 149 - - PUNCT fnp-3682 8 150 salpêtrière salpêtrière PROPN fnp-3682 8 151 , , PUNCT fnp-3682 8 152 paris paris PROPN fnp-3682 8 153 , , PUNCT fnp-3682 8 154 france france PROPN fnp-3682 8 155 anterior anterior PROPN fnp-3682 8 156 skull skull PROPN fnp-3682 8 157 base base PROPN fnp-3682 8 158 meningiomas meningioma NOUN fnp-3682 8 159 were be AUX fnp-3682 8 160 previously previously ADV fnp-3682 8 161 showed show VERB fnp-3682 8 162 to to PART fnp-3682 8 163 have have VERB fnp-3682 8 164 mutations mutation NOUN fnp-3682 8 165 activating activate VERB fnp-3682 8 166 the the DET fnp-3682 8 167 hedgehog hedgehog NOUN fnp-3682 8 168 ( ( PUNCT fnp-3682 8 169 hh hh NOUN fnp-3682 8 170 ) ) PUNCT fnp-3682 8 171 signalling signal VERB fnp-3682 8 172 pathway pathway NOUN fnp-3682 8 173 . . PUNCT fnp-3682 9 1 however however ADV fnp-3682 9 2 , , PUNCT fnp-3682 9 3 identification identification NOUN fnp-3682 9 4 of of ADP fnp-3682 9 5 hh hh ADJ fnp-3682 9 6 - - PUNCT fnp-3682 9 7 activated activated ADJ fnp-3682 9 8 tumours tumour NOUN fnp-3682 9 9 is be AUX fnp-3682 9 10 hampered hamper VERB fnp-3682 9 11 by by ADP fnp-3682 9 12 the the DET fnp-3682 9 13 lack lack NOUN fnp-3682 9 14 of of ADP fnp-3682 9 15 a a DET fnp-3682 9 16 reliable reliable ADJ fnp-3682 9 17 immunohistochemical immunohistochemical ADJ fnp-3682 9 18 marker marker NOUN fnp-3682 9 19 . . PUNCT fnp-3682 10 1 we we PRON fnp-3682 10 2 report report VERB fnp-3682 10 3 gab1 gab1 ADV fnp-3682 10 4 as as ADP fnp-3682 10 5 a a DET fnp-3682 10 6 potential potential ADJ fnp-3682 10 7 immunohistochemical immunohistochemical ADJ fnp-3682 10 8 marker marker NOUN fnp-3682 10 9 of of ADP fnp-3682 10 10 hh hh ADJ fnp-3682 10 11 - - PUNCT fnp-3682 10 12 activated activate VERB fnp-3682 10 13 meningiomas meningioma NOUN fnp-3682 10 14 . . PUNCT fnp-3682 11 1 gab1 gab1 ADJ fnp-3682 11 2 immunolabeling immunolabeling NOUN fnp-3682 11 3 was be AUX fnp-3682 11 4 compared compare VERB fnp-3682 11 5 to to ADP fnp-3682 11 6 smo smo PROPN fnp-3682 11 7 mutation mutation NOUN fnp-3682 11 8 detection detection NOUN fnp-3682 11 9 with with ADP fnp-3682 11 10 sanger sanger PROPN fnp-3682 11 11 and and CCONJ fnp-3682 11 12 ngs ng NOUN fnp-3682 11 13 techniques technique NOUN fnp-3682 11 14 as as ADV fnp-3682 11 15 well well ADV fnp-3682 11 16 as as ADP fnp-3682 11 17 hh hh PROPN fnp-3682 11 18 pathway pathway NOUN fnp-3682 11 19 activation activation NOUN fnp-3682 11 20 study study NOUN fnp-3682 11 21 through through ADP fnp-3682 11 22 mrna mrna PROPN fnp-3682 11 23 expression expression NOUN fnp-3682 11 24 level level NOUN fnp-3682 11 25 analyses analysis NOUN fnp-3682 11 26 in in ADP fnp-3682 11 27 a a DET fnp-3682 11 28 discovery discovery NOUN fnp-3682 11 29 set set NOUN fnp-3682 11 30 of of ADP fnp-3682 11 31 110 110 NUM fnp-3682 11 32 anterior anterior ADJ fnp-3682 11 33 skull skull NOUN fnp-3682 11 34 base base NOUN fnp-3682 11 35 meningiomas meningioma NOUN fnp-3682 11 36 . . PUNCT fnp-3682 12 1 we we PRON fnp-3682 12 2 showed show VERB fnp-3682 12 3 that that SCONJ fnp-3682 12 4 a a DET fnp-3682 12 5 cut cut VERB fnp-3682 12 6 - - PUNCT fnp-3682 12 7 off off ADP fnp-3682 12 8 score score NOUN fnp-3682 12 9 of of ADP fnp-3682 12 10 250 250 NUM fnp-3682 12 11 for for ADP fnp-3682 12 12 the the DET fnp-3682 12 13 gab1 gab1 ADJ fnp-3682 12 14 expression expression NOUN fnp-3682 12 15 score score NOUN fnp-3682 12 16 ( ( PUNCT fnp-3682 12 17 from from ADP fnp-3682 12 18 0 0 NUM fnp-3682 12 19 to to ADP fnp-3682 12 20 400 400 NUM fnp-3682 12 21 ) ) PUNCT fnp-3682 12 22 lead lead VERB fnp-3682 12 23 to to ADP fnp-3682 12 24 excellent excellent ADJ fnp-3682 12 25 detection detection NOUN fnp-3682 12 26 of of ADP fnp-3682 12 27 hh hh PROPN fnp-3682 12 28 pathway pathway NOUN fnp-3682 12 29 mutations mutation NOUN fnp-3682 12 30 ( ( PUNCT fnp-3682 12 31 sensitivity sensitivity NOUN fnp-3682 12 32 100 100 NUM fnp-3682 12 33 % % NOUN fnp-3682 12 34 , , PUNCT fnp-3682 12 35 specificity specificity NOUN fnp-3682 12 36 86 86 NUM fnp-3682 12 37 % % NOUN fnp-3682 12 38 ) ) PUNCT fnp-3682 12 39 . . PUNCT fnp-3682 13 1 the the DET fnp-3682 13 2 prospective prospective ADJ fnp-3682 13 3 validation validation NOUN fnp-3682 13 4 set set NOUN fnp-3682 13 5 of of ADP fnp-3682 13 6 21 21 NUM fnp-3682 13 7 meningiomas meningioma NOUN fnp-3682 13 8 confirmed confirm VERB fnp-3682 13 9 the the DET fnp-3682 13 10 excellent excellent ADJ fnp-3682 13 11 negative negative ADJ fnp-3682 13 12 predictive predictive ADJ fnp-3682 13 13 value value NOUN fnp-3682 13 14 of of ADP fnp-3682 13 15 gab1 gab1 ADJ fnp-3682 13 16 expression expression NOUN fnp-3682 13 17 score score NOUN fnp-3682 13 18 . . PUNCT fnp-3682 14 1 gab1 gab1 ADJ fnp-3682 14 2 immunohistochemistry immunohistochemistry NOUN fnp-3682 14 3 is be AUX fnp-3682 14 4 a a DET fnp-3682 14 5 fast fast ADJ fnp-3682 14 6 and and CCONJ fnp-3682 14 7 cost cost NOUN fnp-3682 14 8 - - PUNCT fnp-3682 14 9 efficient efficient ADJ fnp-3682 14 10 tool tool NOUN fnp-3682 14 11 to to PART fnp-3682 14 12 screen screen VERB fnp-3682 14 13 anterior anterior PROPN fnp-3682 14 14 skull skull PROPN fnp-3682 14 15 base base PROPN fnp-3682 14 16 meningiomas meningioma NOUN fnp-3682 14 17 and and CCONJ fnp-3682 14 18 to to PART fnp-3682 14 19 facilitate facilitate VERB fnp-3682 14 20 the the DET fnp-3682 14 21 identification identification NOUN fnp-3682 14 22 of of ADP fnp-3682 14 23 candidate candidate NOUN fnp-3682 14 24 tumours tumour NOUN fnp-3682 14 25 for for ADP fnp-3682 14 26 targeted target VERB fnp-3682 14 27 therapy therapy NOUN fnp-3682 14 28 . . PUNCT fnp-3682 14 29         SPACE fnp-3682 15 1 free free ADJ fnp-3682 15 2 neuropathol neuropathol NOUN fnp-3682 15 3 2:32:5 2:32:5 NUM fnp-3682 15 4 1p 1p ADJ fnp-3682 15 5 deletion deletion NOUN fnp-3682 15 6 and and CCONJ fnp-3682 15 7 fgfr1 fgfr1 NOUN fnp-3682 15 8 alterations alteration NOUN fnp-3682 15 9 as as ADP fnp-3682 15 10 specific specific ADJ fnp-3682 15 11 diagnostic diagnostic ADJ fnp-3682 15 12 tools tool NOUN fnp-3682 15 13 to to PART fnp-3682 15 14 discriminate discriminate VERB fnp-3682 15 15 dlgnt dlgnt PROPN fnp-3682 15 16 from from ADP fnp-3682 15 17 pa pa PROPN fnp-3682 15 18 in in ADP fnp-3682 15 19 medullary medullary ADJ fnp-3682 15 20 location location NOUN fnp-3682 15 21 : : PUNCT fnp-3682 15 22 an an DET fnp-3682 15 23 integrative integrative ADJ fnp-3682 15 24 radiological radiological ADJ fnp-3682 15 25 and and CCONJ fnp-3682 15 26 histomolecular histomolecular ADJ fnp-3682 15 27 series series NOUN fnp-3682 15 28 of of ADP fnp-3682 15 29 28 28 NUM fnp-3682 15 30 cases case NOUN fnp-3682 15 31 alice alice PROPN fnp-3682 15 32 métais1 métais1 NOUN fnp-3682 15 33 , , PUNCT fnp-3682 15 34 arnault arnault VERB fnp-3682 15 35 tauziède tauziède VERB fnp-3682 15 36 - - PUNCT fnp-3682 15 37 espariat1 espariat1 NOUN fnp-3682 15 38 , , PUNCT fnp-3682 15 39 wael wael PROPN fnp-3682 15 40 yacoub2 yacoub2 PROPN fnp-3682 15 41 , , PUNCT fnp-3682 15 42 thomas thomas PROPN fnp-3682 15 43 kergrohan3 kergrohan3 PROPN fnp-3682 15 44 , , PUNCT fnp-3682 15 45 raphael raphael PROPN fnp-3682 15 46 saffroy4 saffroy4 PROPN fnp-3682 15 47 , , PUNCT fnp-3682 15 48 dominique dominique PROPN fnp-3682 15 49 figarella figarella NOUN fnp-3682 15 50 - - PUNCT fnp-3682 15 51 branger5 branger5 PROPN fnp-3682 15 52 , , PUNCT fnp-3682 15 53 emmanuele emmanuele PROPN fnp-3682 15 54 uro uro PROPN fnp-3682 15 55 - - PUNCT fnp-3682 15 56 coste6 coste6 PROPN fnp-3682 15 57 , , PUNCT fnp-3682 15 58 annick annick PROPN fnp-3682 15 59 sevely7 sevely7 PROPN fnp-3682 15 60 , , PUNCT fnp-3682 15 61 delphine delphine PROPN fnp-3682 15 62 larrieu larrieu PROPN fnp-3682 15 63 - - PUNCT fnp-3682 15 64 cirron8,9 cirron8,9 PROPN fnp-3682 15 65 , , PUNCT fnp-3682 15 66 alexandre alexandre PROPN fnp-3682 15 67 roux10 roux10 PROPN fnp-3682 15 68 , , PUNCT fnp-3682 15 69 sandro sandro PROPN fnp-3682 15 70 benichi11 benichi11 PROPN fnp-3682 15 71 , , PUNCT fnp-3682 15 72 lila lila PROPN fnp-3682 15 73 saidoun3 saidoun3 PROPN fnp-3682 15 74 , , PUNCT fnp-3682 15 75 yassine yassine PROPN fnp-3682 15 76 bouchoucha12 bouchoucha12 PROPN fnp-3682 15 77 , , PUNCT fnp-3682 15 78 françois françois PROPN fnp-3682 15 79 doz12 doz12 PROPN fnp-3682 15 80 , , PUNCT fnp-3682 15 81 volodia volodia NOUN fnp-3682 15 82 dangoulof dangoulof NOUN fnp-3682 15 83 - - PUNCT fnp-3682 15 84 ros2 ros2 PROPN fnp-3682 15 85 , , PUNCT fnp-3682 15 86 jacques jacques PROPN fnp-3682 15 87 grill3 grill3 PROPN fnp-3682 15 88 , , PUNCT fnp-3682 15 89 pascale pascale PROPN fnp-3682 15 90 varlet1 varlet1 NOUN fnp-3682 15 91 1 1 NUM fnp-3682 15 92 department department NOUN fnp-3682 15 93 of of ADP fnp-3682 15 94 neuropathology neuropathology NOUN fnp-3682 15 95 , , PUNCT fnp-3682 15 96 ghu ghu PROPN fnp-3682 15 97 paris paris PROPN fnp-3682 15 98 - - PUNCT fnp-3682 15 99 psychiatrie psychiatrie PROPN fnp-3682 15 100 and and CCONJ fnp-3682 15 101 neurosciences neuroscience NOUN fnp-3682 15 102 , , PUNCT fnp-3682 15 103 sainte sainte PROPN fnp-3682 15 104 - - PUNCT fnp-3682 15 105 anne anne PROPN fnp-3682 15 106 hospital hospital PROPN fnp-3682 15 107 , , PUNCT fnp-3682 15 108 paris paris PROPN fnp-3682 15 109 , , PUNCT fnp-3682 15 110 france france PROPN fnp-3682 15 111 2 2 NUM fnp-3682 15 112 department department NOUN fnp-3682 15 113 of of ADP fnp-3682 15 114 pediatric pediatric ADJ fnp-3682 15 115 radiology radiology NOUN fnp-3682 15 116 , , PUNCT fnp-3682 15 117 hôpital hôpital PROPN fnp-3682 15 118 necker necker PROPN fnp-3682 15 119 - - PUNCT fnp-3682 15 120 enfants enfants X fnp-3682 15 121 malades malades PROPN fnp-3682 15 122 , , PUNCT fnp-3682 15 123 paris paris PROPN fnp-3682 15 124 , , PUNCT fnp-3682 15 125 france france PROPN fnp-3682 15 126 3 3 NUM fnp-3682 15 127 département département X fnp-3682 15 128 de de X fnp-3682 15 129 cancérologie cancérologie X fnp-3682 15 130 de de X fnp-3682 15 131 l'enfant l'enfant X fnp-3682 15 132 et et PROPN fnp-3682 15 133 de de X fnp-3682 15 134 l'adolescent l'adolescent PROPN fnp-3682 15 135 , , PUNCT fnp-3682 15 136 institut institut PROPN fnp-3682 15 137 gustave gustave PROPN fnp-3682 15 138 roussy roussy PROPN fnp-3682 15 139 , , PUNCT fnp-3682 15 140 université université PROPN fnp-3682 15 141 paris paris PROPN fnp-3682 15 142 - - PUNCT fnp-3682 15 143 sud sud PROPN fnp-3682 15 144 , , PUNCT fnp-3682 15 145 villejuif villejuif NOUN fnp-3682 15 146 , , PUNCT fnp-3682 15 147 france france PROPN fnp-3682 15 148 4 4 NUM fnp-3682 15 149 department department PROPN fnp-3682 15 150 of of ADP fnp-3682 15 151 biochemistry biochemistry NOUN fnp-3682 15 152 , , PUNCT fnp-3682 15 153 paul paul PROPN fnp-3682 15 154 - - PUNCT fnp-3682 15 155 brousse brousse PROPN fnp-3682 15 156 hospital hospital NOUN fnp-3682 15 157 , , PUNCT fnp-3682 15 158 villejuif villejuif NOUN fnp-3682 15 159 , , PUNCT fnp-3682 15 160 france france PROPN fnp-3682 15 161 5 5 NUM fnp-3682 15 162 department department NOUN fnp-3682 15 163 of of ADP fnp-3682 15 164 pathology pathology NOUN fnp-3682 15 165 and and CCONJ fnp-3682 15 166 neuropathology neuropathology NOUN fnp-3682 15 167 , , PUNCT fnp-3682 15 168 timone timone ADJ fnp-3682 15 169 hospital hospital NOUN fnp-3682 15 170 , , PUNCT fnp-3682 15 171 marseille marseille PROPN fnp-3682 15 172 , , PUNCT fnp-3682 15 173 france france PROPN fnp-3682 15 174 6 6 NUM fnp-3682 15 175 département département PROPN fnp-3682 15 176 d'anatomie d'anatomie PROPN fnp-3682 15 177 et et PROPN fnp-3682 15 178 cytologie cytologie PROPN fnp-3682 15 179 pathologiques pathologique NOUN fnp-3682 15 180 , , PUNCT fnp-3682 15 181 chu chu PROPN fnp-3682 15 182 de de NOUN fnp-3682 15 183 toulouse toulouse NOUN fnp-3682 15 184 , , PUNCT fnp-3682 15 185 iuct iuct NOUN fnp-3682 15 186 - - PUNCT fnp-3682 15 187 oncopole oncopole NOUN fnp-3682 15 188 , , PUNCT fnp-3682 15 189 toulouse toulouse NOUN fnp-3682 15 190 , , PUNCT fnp-3682 15 191 france france PROPN fnp-3682 15 192 7 7 NUM fnp-3682 15 193 department department NOUN fnp-3682 15 194 of of ADP fnp-3682 15 195 radiology radiology NOUN fnp-3682 15 196 , , PUNCT fnp-3682 15 197 purpan purpan PROPN fnp-3682 15 198 university university NOUN fnp-3682 15 199 hospital hospital NOUN fnp-3682 15 200 , , PUNCT fnp-3682 15 201 toulouse toulouse NOUN fnp-3682 15 202 , , PUNCT fnp-3682 15 203 france france PROPN fnp-3682 15 204 8 8 NUM fnp-3682 15 205 department department PROPN fnp-3682 15 206 of of ADP fnp-3682 15 207 neurology neurology NOUN fnp-3682 15 208 , , PUNCT fnp-3682 15 209 toulouse toulouse NOUN fnp-3682 15 210 university university NOUN fnp-3682 15 211 hospital hospital NOUN fnp-3682 15 212 , , PUNCT fnp-3682 15 213 toulouse toulouse NOUN fnp-3682 15 214 , , PUNCT fnp-3682 15 215 france france PROPN fnp-3682 15 216 9 9 NUM fnp-3682 15 217 department department NOUN fnp-3682 15 218 of of ADP fnp-3682 15 219 medical medical ADJ fnp-3682 15 220 oncology oncology NOUN fnp-3682 15 221 , , PUNCT fnp-3682 15 222 iuct iuct NOUN fnp-3682 15 223 - - PUNCT fnp-3682 15 224 oncopole oncopole NOUN fnp-3682 15 225 , , PUNCT fnp-3682 15 226 toulouse toulouse NOUN fnp-3682 15 227 , , PUNCT fnp-3682 15 228 france france PROPN fnp-3682 15 229 10 10 NUM fnp-3682 15 230 department department NOUN fnp-3682 15 231 of of ADP fnp-3682 15 232 neurosurgery neurosurgery NOUN fnp-3682 15 233 , , PUNCT fnp-3682 15 234 ghu ghu PROPN fnp-3682 15 235 paris paris PROPN fnp-3682 15 236 - - PUNCT fnp-3682 15 237 psychiatrie psychiatrie PROPN fnp-3682 15 238 et et PROPN fnp-3682 15 239 neurosciences neurosciences PROPN fnp-3682 15 240 sainte sainte PROPN fnp-3682 15 241 - - PUNCT fnp-3682 15 242 anne anne PROPN fnp-3682 15 243 hospital hospital PROPN fnp-3682 15 244 , , PUNCT fnp-3682 15 245 paris paris PROPN fnp-3682 15 246 , , PUNCT fnp-3682 15 247 france france PROPN fnp-3682 15 248 11 11 NUM fnp-3682 15 249 department department NOUN fnp-3682 15 250 of of ADP fnp-3682 15 251 pediatric pediatric ADJ fnp-3682 15 252 neurosurgery neurosurgery NOUN fnp-3682 15 253 , , PUNCT fnp-3682 15 254 hôpital hôpital PROPN fnp-3682 15 255 necker necker PROPN fnp-3682 15 256 - - PUNCT fnp-3682 15 257 enfants enfants X fnp-3682 15 258 malades malades PROPN fnp-3682 15 259 , , PUNCT fnp-3682 15 260 paris paris PROPN fnp-3682 15 261 , , PUNCT fnp-3682 15 262 france france PROPN fnp-3682 15 263 12 12 NUM fnp-3682 15 264 siredo siredo PROPN fnp-3682 15 265 center center NOUN fnp-3682 15 266 ( ( PUNCT fnp-3682 15 267 care care NOUN fnp-3682 15 268 , , PUNCT fnp-3682 15 269 innovation innovation NOUN fnp-3682 15 270 , , PUNCT fnp-3682 15 271 research research NOUN fnp-3682 15 272 in in ADP fnp-3682 15 273 , , PUNCT fnp-3682 15 274 children child NOUN fnp-3682 15 275 , , PUNCT fnp-3682 15 276 adolescent adolescent ADJ fnp-3682 15 277 and and CCONJ fnp-3682 15 278 young young ADJ fnp-3682 15 279 adults adult NOUN fnp-3682 15 280 oncology oncology NOUN fnp-3682 15 281 ) ) PUNCT fnp-3682 15 282 , , PUNCT fnp-3682 15 283 institut institut PROPN fnp-3682 15 284 curie curie PROPN fnp-3682 15 285 , , PUNCT fnp-3682 15 286 paris paris PROPN fnp-3682 15 287 , , PUNCT fnp-3682 15 288 france france PROPN fnp-3682 15 289 new new ADJ fnp-3682 15 290 tumor tumor NOUN fnp-3682 15 291 types type NOUN fnp-3682 15 292 such such ADJ fnp-3682 15 293 as as ADP fnp-3682 15 294 diffuse diffuse PROPN fnp-3682 15 295 leptomeningeal leptomeningeal ADJ fnp-3682 15 296 glioneuronal glioneuronal ADJ fnp-3682 15 297 tumors tumor NOUN fnp-3682 15 298 ( ( PUNCT fnp-3682 15 299 dlgnt dlgnt X fnp-3682 15 300 ) ) PUNCT fnp-3682 15 301 have have AUX fnp-3682 15 302 been be AUX fnp-3682 15 303 added add VERB fnp-3682 15 304 to to ADP fnp-3682 15 305 the the DET fnp-3682 15 306 2016 2016 NUM fnp-3682 15 307 who who PRON fnp-3682 15 308 . . PUNCT fnp-3682 16 1 their their PRON fnp-3682 16 2 distinction distinction NOUN fnp-3682 16 3 from from ADP fnp-3682 16 4 others other NOUN fnp-3682 16 5 intramedullary intramedullary ADJ fnp-3682 16 6 gliomas glioma NOUN fnp-3682 16 7 is be AUX fnp-3682 16 8 poorly poorly ADV fnp-3682 16 9 defined define VERB fnp-3682 16 10 . . PUNCT fnp-3682 17 1 we we PRON fnp-3682 17 2 retrospectively retrospectively ADV fnp-3682 17 3 studied study VERB fnp-3682 17 4 a a DET fnp-3682 17 5 cohort cohort NOUN fnp-3682 17 6 of of ADP fnp-3682 17 7 28 28 NUM fnp-3682 17 8 children child NOUN fnp-3682 17 9 with with ADP fnp-3682 17 10 low low ADJ fnp-3682 17 11 - - PUNCT fnp-3682 17 12 grade grade NOUN fnp-3682 17 13 intramedullary intramedullary ADJ fnp-3682 17 14 tumors tumor NOUN fnp-3682 17 15 . . PUNCT fnp-3682 18 1 the the DET fnp-3682 18 2 radiological radiological ADJ fnp-3682 18 3 , , PUNCT fnp-3682 18 4 histopathological histopathological ADJ fnp-3682 18 5 and and CCONJ fnp-3682 18 6 molecular molecular ADJ fnp-3682 18 7 portrait portrait NOUN fnp-3682 18 8 including include VERB fnp-3682 18 9 methylation methylation NOUN fnp-3682 18 10 profiling profiling NOUN fnp-3682 18 11 was be AUX fnp-3682 18 12 established establish VERB fnp-3682 18 13 as as ADV fnp-3682 18 14 well well ADV fnp-3682 18 15 oncological oncological ADJ fnp-3682 18 16 treatments treatment NOUN fnp-3682 18 17 data datum NOUN fnp-3682 18 18 . . PUNCT fnp-3682 19 1 we we PRON fnp-3682 19 2 observed observe VERB fnp-3682 19 3 two two NUM fnp-3682 19 4 main main ADJ fnp-3682 19 5 tumor tumor NOUN fnp-3682 19 6 types type NOUN fnp-3682 19 7 : : PUNCT fnp-3682 19 8 dlgnt dlgnt VERB fnp-3682 19 9 and and CCONJ fnp-3682 19 10 pilocytic pilocytic ADJ fnp-3682 19 11 astrocytomas astrocytoma NOUN fnp-3682 19 12 ( ( PUNCT fnp-3682 19 13 pa pa PROPN fnp-3682 19 14 ) ) PUNCT fnp-3682 19 15 that that PRON fnp-3682 19 16 were be AUX fnp-3682 19 17 hardly hardly ADV fnp-3682 19 18 distinguishable distinguishable ADJ fnp-3682 19 19 by by ADP fnp-3682 19 20 neuroradiology neuroradiology NOUN fnp-3682 19 21 or or CCONJ fnp-3682 19 22 histopathology histopathology NOUN fnp-3682 19 23 alone alone ADV fnp-3682 19 24 . . PUNCT fnp-3682 20 1 the the DET fnp-3682 20 2 major major ADJ fnp-3682 20 3 criteria criterion NOUN fnp-3682 20 4 to to PART fnp-3682 20 5 segregate segregate VERB fnp-3682 20 6 these these DET fnp-3682 20 7 two two NUM fnp-3682 20 8 tumor tumor NOUN fnp-3682 20 9 types type NOUN fnp-3682 20 10 presenting present VERB fnp-3682 20 11 a a DET fnp-3682 20 12 mapkinase mapkinase NOUN fnp-3682 20 13 alteration alteration NOUN fnp-3682 20 14 was be AUX fnp-3682 20 15 the the DET fnp-3682 20 16 1p 1p NUM fnp-3682 20 17 deletion deletion NOUN fnp-3682 20 18 . . PUNCT fnp-3682 21 1 we we PRON fnp-3682 21 2 observed observe VERB fnp-3682 21 3 that that SCONJ fnp-3682 21 4 these these DET fnp-3682 21 5 tumors tumor NOUN fnp-3682 21 6 interested interest VERB fnp-3682 21 7 different different ADJ fnp-3682 21 8 populations population NOUN fnp-3682 21 9 ( ( PUNCT fnp-3682 21 10 infants infant NOUN fnp-3682 21 11 for for ADP fnp-3682 21 12 pa pa PROPN fnp-3682 21 13 , , PUNCT fnp-3682 21 14 school school NOUN fnp-3682 21 15 children child NOUN fnp-3682 21 16 for for ADP fnp-3682 21 17 dlgnt dlgnt NUM fnp-3682 21 18 ) ) PUNCT fnp-3682 21 19 . . PUNCT fnp-3682 22 1 these these DET fnp-3682 22 2 tumors tumor NOUN fnp-3682 22 3 evolved evolve VERB fnp-3682 22 4 insidiously insidiously ADV fnp-3682 22 5 during during ADP fnp-3682 22 6 a a DET fnp-3682 22 7 long long ADJ fnp-3682 22 8 period period NOUN fnp-3682 22 9 of of ADP fnp-3682 22 10 time time NOUN fnp-3682 22 11 , , PUNCT fnp-3682 22 12 remission remission NOUN fnp-3682 22 13 was be AUX fnp-3682 22 14 rarely rarely ADV fnp-3682 22 15 achieved achieve VERB fnp-3682 22 16 ( ( PUNCT fnp-3682 22 17 5/28 5/28 NUM fnp-3682 22 18 ) ) PUNCT fnp-3682 22 19 . . PUNCT fnp-3682 23 1 two two NUM fnp-3682 23 2 cases case NOUN fnp-3682 23 3 had have VERB fnp-3682 23 4 a a DET fnp-3682 23 5 deadly deadly ADJ fnp-3682 23 6 evolution evolution NOUN fnp-3682 23 7 . . PUNCT fnp-3682 24 1 we we PRON fnp-3682 24 2 recommend recommend VERB fnp-3682 24 3 to to AUX fnp-3682 24 4 systematically systematically ADV fnp-3682 24 5 assess assess VERB fnp-3682 24 6 1p 1p NUM fnp-3682 24 7 deletion deletion NOUN fnp-3682 24 8 in in ADP fnp-3682 24 9 intramedullary intramedullary ADJ fnp-3682 24 10 low low ADJ fnp-3682 24 11 - - PUNCT fnp-3682 24 12 grade grade NOUN fnp-3682 24 13 glioma glioma NOUN fnp-3682 24 14 . . PUNCT fnp-3682 25 1 improving improve VERB fnp-3682 25 2 the the DET fnp-3682 25 3 management management NOUN fnp-3682 25 4 of of ADP fnp-3682 25 5 these these DET fnp-3682 25 6 diseases disease NOUN fnp-3682 25 7 remains remain VERB fnp-3682 25 8 a a DET fnp-3682 25 9 major major ADJ fnp-3682 25 10 challenge challenge NOUN fnp-3682 25 11 . . PUNCT fnp-3682 25 12         SPACE fnp-3682 26 1 free free ADJ fnp-3682 26 2 neuropathol neuropathol NOUN fnp-3682 26 3 2:32:6 2:32:6 NUM fnp-3682 26 4 classification classification NOUN fnp-3682 26 5 of of ADP fnp-3682 26 6 pituitary pituitary ADJ fnp-3682 26 7 neuroendocrine neuroendocrine ADJ fnp-3682 26 8 tumors tumor NOUN fnp-3682 26 9 : : PUNCT fnp-3682 26 10 genomic genomic NOUN fnp-3682 26 11 data datum NOUN fnp-3682 26 12 on on ADP fnp-3682 26 13 cell cell NOUN fnp-3682 26 14 lineage lineage NOUN fnp-3682 26 15 villa villa PROPN fnp-3682 26 16 c.1,2 c.1,2 PROPN fnp-3682 26 17 , , PUNCT fnp-3682 26 18 armignacco armignacco NOUN fnp-3682 26 19 r.2 r.2 ADJ fnp-3682 26 20 , , PUNCT fnp-3682 26 21 jouinot jouinot ADV fnp-3682 26 22 a.2 a.2 PUNCT fnp-3682 26 23 , , PUNCT fnp-3682 26 24 perlemoine perlemoine ADJ fnp-3682 26 25 k.2 k.2 NOUN fnp-3682 26 26 , , PUNCT fnp-3682 26 27 baussart baussart PROPN fnp-3682 26 28 b.3 b.3 PROPN fnp-3682 26 29 , , PUNCT fnp-3682 26 30 bertherat bertherat NOUN fnp-3682 26 31 j.4,2 j.4,2 PROPN fnp-3682 26 32 , , PUNCT fnp-3682 26 33 gaillard gaillard PROPN fnp-3682 26 34 s.3 s.3 PROPN fnp-3682 26 35 , , PUNCT fnp-3682 26 36 assié assié ADJ fnp-3682 26 37 g. g. NOUN fnp-3682 26 38 4,2 4,2 NUM fnp-3682 26 39 1 1 NUM fnp-3682 26 40 department department NOUN fnp-3682 26 41 of of ADP fnp-3682 26 42 neuropathology neuropathology NOUN fnp-3682 26 43 , , PUNCT fnp-3682 26 44 hôpital hôpital PROPN fnp-3682 26 45 de de PROPN fnp-3682 26 46 la la PROPN fnp-3682 26 47 pitié pitié PROPN fnp-3682 26 48 - - PUNCT fnp-3682 26 49 salpêtrière salpêtrière NOUN fnp-3682 26 50 aphp aphp PROPN fnp-3682 26 51 sorbonne sorbonne PROPN fnp-3682 26 52 université université PROPN fnp-3682 26 53 , , PUNCT fnp-3682 26 54 47 47 NUM fnp-3682 26 55 - - SYM fnp-3682 26 56 83 83 NUM fnp-3682 26 57 bd bd PROPN fnp-3682 26 58 de de PROPN fnp-3682 26 59 l’hôpital l’hôpital PROPN fnp-3682 26 60 75651 75651 NUM fnp-3682 26 61 paris paris PROPN fnp-3682 26 62 , , PUNCT fnp-3682 26 63 france france PROPN fnp-3682 26 64 2 2 NUM fnp-3682 26 65 inserm inserm NOUN fnp-3682 26 66 u1016 u1016 PROPN fnp-3682 26 67 , , PUNCT fnp-3682 26 68 institut institut PROPN fnp-3682 26 69 cochin cochin PROPN fnp-3682 26 70 , , PUNCT fnp-3682 26 71 75014 75014 NUM fnp-3682 26 72 paris paris PROPN fnp-3682 26 73 , , PUNCT fnp-3682 26 74 france france PROPN fnp-3682 26 75 ; ; PUNCT fnp-3682 26 76 cnrs cnrs NOUN fnp-3682 26 77 umr umr PROPN fnp-3682 26 78 8104 8104 NUM fnp-3682 26 79 , , PUNCT fnp-3682 26 80 75014 75014 NUM fnp-3682 26 81 paris paris PROPN fnp-3682 26 82 , , PUNCT fnp-3682 26 83 france france PROPN fnp-3682 26 84 ; ; PUNCT fnp-3682 26 85 université université PROPN fnp-3682 26 86 paris paris PROPN fnp-3682 26 87 descartes descartes PROPN fnp-3682 26 88 - - PUNCT fnp-3682 26 89 université université PROPN fnp-3682 26 90 de de PROPN fnp-3682 26 91 paris paris PROPN fnp-3682 26 92 , , PUNCT fnp-3682 26 93 75006 75006 NUM fnp-3682 26 94 paris paris PROPN fnp-3682 26 95 , , PUNCT fnp-3682 26 96 france france PROPN fnp-3682 26 97 3 3 NUM fnp-3682 26 98 department department NOUN fnp-3682 26 99 of of ADP fnp-3682 26 100 neurosurgery neurosurgery NOUN fnp-3682 26 101 , , PUNCT fnp-3682 26 102 hôpital hôpital PROPN fnp-3682 26 103 de de PROPN fnp-3682 26 104 la la PROPN fnp-3682 26 105 pitié pitié PROPN fnp-3682 26 106 - - PUNCT fnp-3682 26 107 salpêtrière salpêtrière NOUN fnp-3682 26 108 aphp aphp PROPN fnp-3682 26 109 sorbonne sorbonne PROPN fnp-3682 26 110 université université PROPN fnp-3682 26 111 , , PUNCT fnp-3682 26 112 76561 76561 PROPN fnp-3682 26 113 paris paris PROPN fnp-3682 26 114 , , PUNCT fnp-3682 26 115 france france PROPN fnp-3682 26 116 4 4 NUM fnp-3682 26 117 department department NOUN fnp-3682 26 118 of of ADP fnp-3682 26 119 endocrinology endocrinology NOUN fnp-3682 26 120 , , PUNCT fnp-3682 26 121 center center NOUN fnp-3682 26 122 for for ADP fnp-3682 26 123 rare rare ADJ fnp-3682 26 124 adrenal adrenal ADJ fnp-3682 26 125 diseases disease NOUN fnp-3682 26 126 , , PUNCT fnp-3682 26 127 assistance assistance NOUN fnp-3682 26 128 publique publique ADJ fnp-3682 26 129 - - PUNCT fnp-3682 26 130 hôpitaux hôpitaux PROPN fnp-3682 26 131 de de PROPN fnp-3682 26 132 paris paris PROPN fnp-3682 26 133 , , PUNCT fnp-3682 26 134 hôpital hôpital PROPN fnp-3682 26 135 cochin cochin PROPN fnp-3682 26 136 , , PUNCT fnp-3682 26 137 75014 75014 NUM fnp-3682 26 138 paris paris PROPN fnp-3682 26 139 , , PUNCT fnp-3682 26 140 france france PROPN fnp-3682 26 141 the the DET fnp-3682 26 142 2017 2017 NUM fnp-3682 26 143 world world NOUN fnp-3682 26 144 health health NOUN fnp-3682 26 145 organization organization NOUN fnp-3682 26 146 ( ( PUNCT fnp-3682 26 147 who who PRON fnp-3682 26 148 ) ) PUNCT fnp-3682 26 149 classification classification NOUN fnp-3682 26 150 of of ADP fnp-3682 26 151 pituitary pituitary ADJ fnp-3682 26 152 adenomas adenoma NOUN fnp-3682 26 153 is be AUX fnp-3682 26 154 based base VERB fnp-3682 26 155 on on ADP fnp-3682 26 156 cell cell NOUN fnp-3682 26 157 lineage lineage NOUN fnp-3682 26 158 and and CCONJ fnp-3682 26 159 transcription transcription NOUN fnp-3682 26 160 factors factor NOUN fnp-3682 26 161 ( ( PUNCT fnp-3682 26 162 tfs tfs PROPN fnp-3682 26 163 ) ) PUNCT fnp-3682 26 164 . . PUNCT fnp-3682 27 1 transcriptome transcriptome NOUN fnp-3682 27 2 of of ADP fnp-3682 27 3 134 134 NUM fnp-3682 27 4 pitnets pitnet NOUN fnp-3682 27 5 ( ( PUNCT fnp-3682 27 6 rna rna NOUN fnp-3682 27 7 sequencing sequencing NOUN fnp-3682 27 8 ) ) PUNCT fnp-3682 27 9 was be AUX fnp-3682 27 10 used use VERB fnp-3682 27 11 to to PART fnp-3682 27 12 determine determine VERB fnp-3682 27 13 tfs tfs PROPN fnp-3682 27 14 expression expression NOUN fnp-3682 27 15 at at ADP fnp-3682 27 16 mrna mrna PROPN fnp-3682 27 17 level level NOUN fnp-3682 27 18 , , PUNCT fnp-3682 27 19 and and CCONJ fnp-3682 27 20 to to PART fnp-3682 27 21 provide provide VERB fnp-3682 27 22 a a DET fnp-3682 27 23 canonical canonical ADJ fnp-3682 27 24 transcriptome transcriptome ADJ fnp-3682 27 25 signature signature NOUN fnp-3682 27 26 for for ADP fnp-3682 27 27 each each DET fnp-3682 27 28 cell cell NOUN fnp-3682 27 29 - - PUNCT fnp-3682 27 30 types type NOUN fnp-3682 27 31 . . PUNCT fnp-3682 28 1 pathological pathological ADJ fnp-3682 28 2 study study NOUN fnp-3682 28 3 of of ADP fnp-3682 28 4 the the DET fnp-3682 28 5 present present ADJ fnp-3682 28 6 serie serie NOUN fnp-3682 28 7 of of ADP fnp-3682 28 8 pitnets pitnet NOUN fnp-3682 28 9 included include VERB fnp-3682 28 10 the the DET fnp-3682 28 11 histological histological ADJ fnp-3682 28 12 examination examination NOUN fnp-3682 28 13 and and CCONJ fnp-3682 28 14 the the DET fnp-3682 28 15 immunohistochemical immunohistochemical ADJ fnp-3682 28 16 tests test NOUN fnp-3682 28 17 for for ADP fnp-3682 28 18 all all DET fnp-3682 28 19 pituitary pituitary ADJ fnp-3682 28 20 hormones hormone NOUN fnp-3682 28 21 , , PUNCT fnp-3682 28 22 proliferation proliferation NOUN fnp-3682 28 23 markers marker NOUN fnp-3682 28 24 and and CCONJ fnp-3682 28 25 tfs tfs PROPN fnp-3682 28 26 including include VERB fnp-3682 28 27 gata3 gata3 PROPN fnp-3682 28 28 . . PUNCT fnp-3682 29 1 pit1 pit1 NOUN fnp-3682 29 2 lineage lineage NOUN fnp-3682 29 3 : : PUNCT fnp-3682 29 4 based base VERB fnp-3682 29 5 on on ADP fnp-3682 29 6 transcriptome transcriptome ADJ fnp-3682 29 7 classification classification NOUN fnp-3682 29 8 , , PUNCT fnp-3682 29 9 accurate accurate ADJ fnp-3682 29 10 thresholds threshold NOUN fnp-3682 29 11 of of ADP fnp-3682 29 12 immunoexpression immunoexpression NOUN fnp-3682 29 13 for for ADP fnp-3682 29 14 gh gh PROPN fnp-3682 29 15 , , PUNCT fnp-3682 29 16 prl prl PROPN fnp-3682 29 17 and and CCONJ fnp-3682 29 18 tsh tsh NOUN fnp-3682 29 19 were be AUX fnp-3682 29 20 established establish VERB fnp-3682 29 21 in in ADP fnp-3682 29 22 order order NOUN fnp-3682 29 23 to to PART fnp-3682 29 24 define define VERB fnp-3682 29 25 the the DET fnp-3682 29 26 different different ADJ fnp-3682 29 27 pit-1 pit-1 PUNCT fnp-3682 29 28 subtypes subtype NOUN fnp-3682 29 29 . . PUNCT fnp-3682 30 1 t t NOUN fnp-3682 30 2 - - PUNCT fnp-3682 30 3 pit pit NOUN fnp-3682 30 4 lineage lineage NOUN fnp-3682 30 5 : : PUNCT fnp-3682 30 6 t t NOUN fnp-3682 30 7 - - PUNCT fnp-3682 30 8 pit pit NOUN fnp-3682 30 9 mrna mrna PROPN fnp-3682 30 10 showed show VERB fnp-3682 30 11 the the DET fnp-3682 30 12 expected expect VERB fnp-3682 30 13 expression expression NOUN fnp-3682 30 14 in in ADP fnp-3682 30 15 corticotroph corticotroph ADJ fnp-3682 30 16 pitnets pitnet NOUN fnp-3682 30 17 ( ( PUNCT fnp-3682 30 18 35/35 35/35 NUM fnp-3682 30 19 ) ) PUNCT fnp-3682 30 20 , , PUNCT fnp-3682 30 21 lower low ADJ fnp-3682 30 22 in in ADP fnp-3682 30 23 silent silent ADJ fnp-3682 30 24 ones one NOUN fnp-3682 30 25 ( ( PUNCT fnp-3682 30 26 wilcoxon wilcoxon PROPN fnp-3682 30 27 p<10 p<10 NOUN fnp-3682 30 28 - - PUNCT fnp-3682 30 29 5 5 NUM fnp-3682 30 30 ) ) PUNCT fnp-3682 30 31 . . PUNCT fnp-3682 31 1 gonadotroph gonadotroph NOUN fnp-3682 31 2 lineage lineage NOUN fnp-3682 31 3 : : PUNCT fnp-3682 31 4 sf1 sf1 PROPN fnp-3682 31 5 mrna mrna PROPN fnp-3682 31 6 expression expression NOUN fnp-3682 31 7 showed show VERB fnp-3682 31 8 the the DET fnp-3682 31 9 expected expect VERB fnp-3682 31 10 high high ADJ fnp-3682 31 11 expression expression NOUN fnp-3682 31 12 in in ADP fnp-3682 31 13 gonadotroph gonadotroph NOUN fnp-3682 31 14 pitnets pitnet NOUN fnp-3682 31 15 ( ( PUNCT fnp-3682 31 16 29/29 29/29 NUM fnp-3682 31 17 ) ) PUNCT fnp-3682 31 18 , , PUNCT fnp-3682 31 19 but but CCONJ fnp-3682 31 20 also also ADV fnp-3682 31 21 in in ADP fnp-3682 31 22 a a DET fnp-3682 31 23 subset subset NOUN fnp-3682 31 24 of of ADP fnp-3682 31 25 somatotroph somatotroph PROPN fnp-3682 31 26 pitnets pitnet NOUN fnp-3682 31 27 ( ( PUNCT fnp-3682 31 28 9/21 9/21 NUM fnp-3682 31 29 ) ) PUNCT fnp-3682 31 30 . . PUNCT fnp-3682 32 1 sf1 sf1 PROPN fnp-3682 32 2 immunopositivity immunopositivity NOUN fnp-3682 32 3 was be AUX fnp-3682 32 4 confirmed confirm VERB fnp-3682 32 5 in in ADP fnp-3682 32 6 this this DET fnp-3682 32 7 somatotroph somatotroph PROPN fnp-3682 32 8 subgroup subgroup PROPN fnp-3682 32 9 . . PUNCT fnp-3682 32 10         SPACE fnp-3682 33 1 free free ADJ fnp-3682 33 2 neuropathol neuropathol NOUN fnp-3682 33 3 2:32:7 2:32:7 NUM fnp-3682 33 4 large large ADJ fnp-3682 33 5 brain brain NOUN fnp-3682 33 6 vessel vessel NOUN fnp-3682 33 7 vasculitis vasculitis PROPN fnp-3682 33 8 in in ADP fnp-3682 33 9 immunocompromised immunocompromise VERB fnp-3682 33 10 patients patient NOUN fnp-3682 33 11 isabelle isabelle PROPN fnp-3682 33 12 plu1 plu1 PROPN fnp-3682 33 13 , , PUNCT fnp-3682 33 14 elie elie PROPN fnp-3682 33 15 haddad2 haddad2 PROPN fnp-3682 33 16 , , PUNCT fnp-3682 33 17 arnaud arnaud PROPN fnp-3682 33 18 fekkar3 fekkar3 PROPN fnp-3682 33 19 , , PUNCT fnp-3682 33 20 sophie sophie PROPN fnp-3682 33 21 bonnin4 bonnin4 PROPN fnp-3682 33 22 , , PUNCT fnp-3682 33 23 natalia natalia PROPN fnp-3682 33 24 shor5 shor5 PROPN fnp-3682 33 25 , , PUNCT fnp-3682 33 26 valérie valérie ADJ fnp-3682 33 27 touitou4 touitou4 NOUN fnp-3682 33 28 , , PUNCT fnp-3682 33 29 véronique véronique ADJ fnp-3682 33 30 leblond6 leblond6 NOUN fnp-3682 33 31 , , PUNCT fnp-3682 33 32 nicolas nicolas PROPN fnp-3682 33 33 weiss7 weiss7 PROPN fnp-3682 33 34 , , PUNCT fnp-3682 33 35 eric eric PROPN fnp-3682 33 36 caumes2 caumes2 PROPN fnp-3682 33 37 , , PUNCT fnp-3682 33 38 sophie sophie PROPN fnp-3682 33 39 demeret7 demeret7 NOUN fnp-3682 33 40 , , PUNCT fnp-3682 33 41 valérie valérie ADJ fnp-3682 33 42 pourcher2 pourcher2 PROPN fnp-3682 33 43 , , PUNCT fnp-3682 33 44 danielle danielle PROPN fnp-3682 33 45 seilhean1 seilhean1 X fnp-3682 34 1 sorbonne sorbonne PROPN fnp-3682 34 2 université université PROPN fnp-3682 34 3 , , PUNCT fnp-3682 34 4 ap ap PROPN fnp-3682 34 5 - - PUNCT fnp-3682 34 6 hp hp PROPN fnp-3682 34 7 , , PUNCT fnp-3682 34 8 hôpitaux hôpitaux NOUN fnp-3682 34 9 universitaires universitaire NOUN fnp-3682 34 10 pitié pitié PROPN fnp-3682 34 11 - - PUNCT fnp-3682 34 12 salpêtrière salpêtrière PROPN fnp-3682 34 13 charles charles PROPN fnp-3682 34 14 foix foix PROPN fnp-3682 34 15 , , PUNCT fnp-3682 34 16 75013 75013 NUM fnp-3682 34 17 paris paris PROPN fnp-3682 34 18 , , PUNCT fnp-3682 34 19 france france PROPN fnp-3682 34 20 1 1 NUM fnp-3682 34 21 département département X fnp-3682 34 22 de de X fnp-3682 34 23 neuropathologie neuropathologie X fnp-3682 34 24 2 2 NUM fnp-3682 34 25 service service NOUN fnp-3682 34 26 de de X fnp-3682 34 27 maladies malady NOUN fnp-3682 34 28 infectieuses infectieuse NOUN fnp-3682 34 29 et et NOUN fnp-3682 34 30 tropicales tropicale VERB fnp-3682 34 31 3 3 NUM fnp-3682 34 32 service service NOUN fnp-3682 34 33 de de X fnp-3682 34 34 parasitologie parasitologie X fnp-3682 34 35 - - PUNCT fnp-3682 34 36 mycologie mycologie NOUN fnp-3682 34 37 4 4 NUM fnp-3682 34 38 service service NOUN fnp-3682 34 39 d’ophtalmologie d’ophtalmologie NOUN fnp-3682 34 40 5 5 NUM fnp-3682 34 41 département département X fnp-3682 34 42 de de X fnp-3682 34 43 neuroradiology neuroradiology NOUN fnp-3682 34 44 6 6 NUM fnp-3682 34 45 service service NOUN fnp-3682 34 46 d’hématologie d’hématologie NOUN fnp-3682 34 47 7 7 NUM fnp-3682 34 48 service service NOUN fnp-3682 34 49 de de X fnp-3682 34 50 neurologie neurologie X fnp-3682 34 51 inflammation inflammation NOUN fnp-3682 34 52 of of ADP fnp-3682 34 53 the the DET fnp-3682 34 54 large large ADJ fnp-3682 34 55 arteries artery NOUN fnp-3682 34 56 of of ADP fnp-3682 34 57 the the DET fnp-3682 34 58 brain brain NOUN fnp-3682 34 59 is be AUX fnp-3682 34 60 a a DET fnp-3682 34 61 relatively relatively ADV fnp-3682 34 62 rare rare ADJ fnp-3682 34 63 condition condition NOUN fnp-3682 34 64 whose whose DET fnp-3682 34 65 best well ADV fnp-3682 34 66 known know VERB fnp-3682 34 67 mechanism mechanism NOUN fnp-3682 34 68 is be AUX fnp-3682 34 69 hyperimmunity hyperimmunity NOUN fnp-3682 34 70 with with ADP fnp-3682 34 71 granulomatous granulomatous ADJ fnp-3682 34 72 reaction reaction NOUN fnp-3682 34 73 or or CCONJ fnp-3682 34 74 circulating circulating ADJ fnp-3682 34 75 immune immune ADJ fnp-3682 34 76 complexes complex NOUN fnp-3682 34 77 . . PUNCT fnp-3682 35 1 some some DET fnp-3682 35 2 vasculitides vasculitide NOUN fnp-3682 35 3 are be AUX fnp-3682 35 4 secondary secondary ADJ fnp-3682 35 5 to to ADP fnp-3682 35 6 a a DET fnp-3682 35 7 systemic systemic ADJ fnp-3682 35 8 hyperimmune hyperimmune NOUN fnp-3682 35 9 disease disease NOUN fnp-3682 35 10 or or CCONJ fnp-3682 35 11 to to ADP fnp-3682 35 12 an an DET fnp-3682 35 13 infectious infectious ADJ fnp-3682 35 14 disease disease NOUN fnp-3682 35 15 ( ( PUNCT fnp-3682 35 16 purulent purulent ADJ fnp-3682 35 17 or or CCONJ fnp-3682 35 18 tuberculous tuberculous ADJ fnp-3682 35 19 meningitis meningiti NOUN fnp-3682 35 20 ) ) PUNCT fnp-3682 35 21 . . PUNCT fnp-3682 36 1 we we PRON fnp-3682 36 2 describe describe VERB fnp-3682 36 3 here here ADV fnp-3682 36 4 the the DET fnp-3682 36 5 occurrence occurrence NOUN fnp-3682 36 6 of of ADP fnp-3682 36 7 cerebral cerebral ADJ fnp-3682 36 8 infarcts infarct NOUN fnp-3682 36 9 in in ADP fnp-3682 36 10 three three NUM fnp-3682 36 11 immunocompromised immunocompromise VERB fnp-3682 36 12 patients patient NOUN fnp-3682 36 13 with with ADP fnp-3682 36 14 neutrophilic neutrophilic ADJ fnp-3682 36 15 aseptic aseptic ADJ fnp-3682 36 16 meningitis meningitis NOUN fnp-3682 36 17 . . PUNCT fnp-3682 37 1 the the DET fnp-3682 37 2 mri mri NOUN fnp-3682 37 3 appearance appearance NOUN fnp-3682 37 4 was be AUX fnp-3682 37 5 vasculitis vasculiti VERB fnp-3682 37 6 of of ADP fnp-3682 37 7 the the DET fnp-3682 37 8 anterior anterior ADJ fnp-3682 37 9 cerebral cerebral ADJ fnp-3682 37 10 arteries artery NOUN fnp-3682 37 11 ( ( PUNCT fnp-3682 37 12 one one NUM fnp-3682 37 13 case case NOUN fnp-3682 37 14 ) ) PUNCT fnp-3682 37 15 or or CCONJ fnp-3682 37 16 basilar basilar ADJ fnp-3682 37 17 arteries artery NOUN fnp-3682 37 18 ( ( PUNCT fnp-3682 37 19 two two NUM fnp-3682 37 20 cases case NOUN fnp-3682 37 21 ) ) PUNCT fnp-3682 37 22 . . PUNCT fnp-3682 38 1 pcr pcr PROPN fnp-3682 38 2 found find VERB fnp-3682 38 3 aspergillus aspergillus ADJ fnp-3682 38 4 fumigatus fumigatus NOUN fnp-3682 38 5 in in ADP fnp-3682 38 6 the the DET fnp-3682 38 7 csf csf ADJ fnp-3682 38 8 two two NUM fnp-3682 38 9 days day NOUN fnp-3682 38 10 before before SCONJ fnp-3682 38 11 a a DET fnp-3682 38 12 positive positive ADJ fnp-3682 38 13 cavum cavum NOUN fnp-3682 38 14 biopsy biopsy VERB fnp-3682 38 15 in in ADP fnp-3682 38 16 one one NUM fnp-3682 38 17 case case NOUN fnp-3682 38 18 . . PUNCT fnp-3682 39 1 in in ADP fnp-3682 39 2 the the DET fnp-3682 39 3 other other ADJ fnp-3682 39 4 two two NUM fnp-3682 39 5 cases case NOUN fnp-3682 39 6 , , PUNCT fnp-3682 39 7 aspergillus aspergillus ADJ fnp-3682 39 8 fumigatus fumigatus NOUN fnp-3682 39 9 was be AUX fnp-3682 39 10 found find VERB fnp-3682 39 11 postmortem postmortem NOUN fnp-3682 39 12 . . PUNCT fnp-3682 40 1 the the DET fnp-3682 40 2 neuropathologic neuropathologic ADJ fnp-3682 40 3 appearance appearance NOUN fnp-3682 40 4 was be AUX fnp-3682 40 5 that that PRON fnp-3682 40 6 of of ADP fnp-3682 40 7 filament filament NOUN fnp-3682 40 8 - - PUNCT fnp-3682 40 9 rich rich ADJ fnp-3682 40 10 necrotizing necrotizing NOUN fnp-3682 40 11 arteritis arteritis NOUN fnp-3682 40 12 . . PUNCT fnp-3682 41 1 there there PRON fnp-3682 41 2 was be VERB fnp-3682 41 3 no no DET fnp-3682 41 4 other other ADJ fnp-3682 41 5 organ organ NOUN fnp-3682 41 6 involvement involvement NOUN fnp-3682 41 7 . . PUNCT fnp-3682 42 1 these these DET fnp-3682 42 2 observations observation NOUN fnp-3682 42 3 highlight highlight VERB fnp-3682 42 4 a a DET fnp-3682 42 5 probably probably ADV fnp-3682 42 6 underestimated underestimate VERB fnp-3682 42 7 cause cause NOUN fnp-3682 42 8 of of ADP fnp-3682 42 9 central central ADJ fnp-3682 42 10 nervous nervous ADJ fnp-3682 42 11 system system NOUN fnp-3682 42 12 arteritis arteritis NOUN fnp-3682 42 13 whose whose DET fnp-3682 42 14 curability curability NOUN fnp-3682 42 15 relies rely VERB fnp-3682 42 16 on on ADP fnp-3682 42 17 early early ADJ fnp-3682 42 18 diagnosis diagnosis NOUN fnp-3682 42 19 based base VERB fnp-3682 42 20 on on ADP fnp-3682 42 21 repeated repeat VERB fnp-3682 42 22 and and CCONJ fnp-3682 42 23 extensive extensive ADJ fnp-3682 42 24 mycological mycological ADJ fnp-3682 42 25 testing testing NOUN fnp-3682 42 26 in in ADP fnp-3682 42 27 csf csf PROPN fnp-3682 42 28 . . PUNCT fnp-3682 42 29         SPACE fnp-3682 42 30 free free ADJ fnp-3682 42 31 neuropathol neuropathol NOUN fnp-3682 42 32 2:32:8 2:32:8 NUM fnp-3682 42 33 cerebellar cerebellar X fnp-3682 42 34 ataxia ataxia NOUN fnp-3682 42 35 with with ADP fnp-3682 42 36 neuropathy neuropathy ADJ fnp-3682 42 37 and and CCONJ fnp-3682 42 38 vestibular vestibular ADJ fnp-3682 42 39 areflexia areflexia PROPN fnp-3682 42 40 syndrome syndrome NOUN fnp-3682 42 41 ( ( PUNCT fnp-3682 42 42 canvas canvas NOUN fnp-3682 42 43 ): ): PUNCT fnp-3682 42 44 a a DET fnp-3682 42 45 case case NOUN fnp-3682 42 46 report report VERB fnp-3682 42 47 susana susana PROPN fnp-3682 42 48 boluda1 boluda1 PROPN fnp-3682 42 49 , , PUNCT fnp-3682 42 50 david david PROPN fnp-3682 42 51 grabli2 grabli2 PROPN fnp-3682 42 52 , , PUNCT fnp-3682 42 53 vincent vincent PROPN fnp-3682 42 54 huin3 huin3 PROPN fnp-3682 42 55 , , PUNCT fnp-3682 42 56 giulia giulia PROPN fnp-3682 42 57 coarelli4 coarelli4 PROPN fnp-3682 42 58 , , PUNCT fnp-3682 42 59 alexandra alexandra PROPN fnp-3682 42 60 durr4 durr4 PROPN fnp-3682 42 61 , , PUNCT fnp-3682 42 62 danielle danielle PROPN fnp-3682 42 63 seilhean1 seilhean1 X fnp-3682 42 64 1 1 NUM fnp-3682 42 65 sorbonne sorbonne PROPN fnp-3682 42 66 université université NOUN fnp-3682 42 67 , , PUNCT fnp-3682 42 68 institut institut PROPN fnp-3682 42 69 du du PROPN fnp-3682 42 70 cerveau cerveau PROPN fnp-3682 42 71 paris paris PROPN fnp-3682 42 72 brain brain PROPN fnp-3682 42 73 institute institute PROPN fnp-3682 42 74 icm icm PROPN fnp-3682 42 75 , , PUNCT fnp-3682 42 76 inserm inserm NOUN fnp-3682 42 77 , , PUNCT fnp-3682 42 78 cnrs cnrs NOUN fnp-3682 42 79 , , PUNCT fnp-3682 42 80 aphp aphp ADJ fnp-3682 42 81 , , PUNCT fnp-3682 42 82 laboratoire laboratoire PROPN fnp-3682 42 83 neuropathologie neuropathologie PROPN fnp-3682 42 84 raymond raymond PROPN fnp-3682 42 85 escourolle escourolle PROPN fnp-3682 42 86 , , PUNCT fnp-3682 42 87 hôpital hôpital PROPN fnp-3682 42 88 de de PROPN fnp-3682 42 89 la la PROPN fnp-3682 42 90 pitié pitié NOUN fnp-3682 42 91 salpêtrière salpêtrière NOUN fnp-3682 42 92 , , PUNCT fnp-3682 42 93 paris paris PROPN fnp-3682 42 94 , , PUNCT fnp-3682 42 95 france france PROPN fnp-3682 42 96 2 2 NUM fnp-3682 42 97 ap ap PROPN fnp-3682 42 98 - - PUNCT fnp-3682 42 99 hp hp PROPN fnp-3682 42 100 , , PUNCT fnp-3682 42 101 pitié pitié NOUN fnp-3682 42 102 salpêtrière salpêtrière NOUN fnp-3682 42 103 university university NOUN fnp-3682 42 104 hospital hospital NOUN fnp-3682 42 105 , , PUNCT fnp-3682 42 106 department department NOUN fnp-3682 42 107 of of ADP fnp-3682 42 108 neurology neurology NOUN fnp-3682 42 109 , , PUNCT fnp-3682 42 110 sorbonne sorbonne PROPN fnp-3682 42 111 university university PROPN fnp-3682 42 112 , , PUNCT fnp-3682 42 113 paris paris PROPN fnp-3682 42 114 , , PUNCT fnp-3682 42 115 france france PROPN fnp-3682 42 116 3 3 NUM fnp-3682 42 117 sorbonne sorbonne PROPN fnp-3682 42 118 université université PROPN fnp-3682 42 119 , , PUNCT fnp-3682 42 120 institut institut PROPN fnp-3682 42 121 du du PROPN fnp-3682 42 122 cerveau cerveau PROPN fnp-3682 42 123 paris paris PROPN fnp-3682 42 124 brain brain PROPN fnp-3682 42 125 instituteicm instituteicm PROPN fnp-3682 42 126 , , PUNCT fnp-3682 42 127 inserm inserm NOUN fnp-3682 42 128 , , PUNCT fnp-3682 42 129 cnrs cnrs NOUN fnp-3682 42 130 ; ; PUNCT fnp-3682 42 131 university university NOUN fnp-3682 42 132 of of ADP fnp-3682 42 133 lille lille PROPN fnp-3682 42 134 , , PUNCT fnp-3682 42 135 univ univ PROPN fnp-3682 42 136 . . PUNCT fnp-3682 43 1 lille lille PROPN fnp-3682 43 2 , , PUNCT fnp-3682 43 3 inserm inserm PROPN fnp-3682 43 4 , , PUNCT fnp-3682 43 5 chu chu PROPN fnp-3682 43 6 lille lille PROPN fnp-3682 43 7 , , PUNCT fnp-3682 43 8 u1172 u1172 NOUN fnp-3682 43 9 lilncog lilncog VERB fnp-3682 43 10 ( ( PUNCT fnp-3682 43 11 jparc jparc PROPN fnp-3682 43 12 ) ) PUNCT fnp-3682 43 13 lille lille PROPN fnp-3682 43 14 neuroscience neuroscience NOUN fnp-3682 43 15 & & CCONJ fnp-3682 43 16 cognition cognition NOUN fnp-3682 43 17 , , PUNCT fnp-3682 43 18 lille lille PROPN fnp-3682 43 19 , , PUNCT fnp-3682 43 20 france france PROPN fnp-3682 43 21 4 4 NUM fnp-3682 43 22 sorbonne sorbonne PROPN fnp-3682 43 23 université université NOUN fnp-3682 43 24 , , PUNCT fnp-3682 43 25 institut institut PROPN fnp-3682 43 26 du du PROPN fnp-3682 43 27 cerveau cerveau PROPN fnp-3682 43 28 paris paris PROPN fnp-3682 43 29 brain brain PROPN fnp-3682 43 30 institute institute PROPN fnp-3682 43 31 icm icm PROPN fnp-3682 43 32 , , PUNCT fnp-3682 43 33 inserm inserm NOUN fnp-3682 43 34 , , PUNCT fnp-3682 43 35 cnrs cnrs NOUN fnp-3682 43 36 , , PUNCT fnp-3682 43 37 aphp aphp ADJ fnp-3682 43 38 , , PUNCT fnp-3682 43 39 genetics genetics PROPN fnp-3682 43 40 department department NOUN fnp-3682 43 41 , , PUNCT fnp-3682 43 42 hôpital hôpital PROPN fnp-3682 43 43 de de PROPN fnp-3682 43 44 la la PROPN fnp-3682 43 45 pitié pitié NOUN fnp-3682 43 46 salpêtrière salpêtrière NOUN fnp-3682 43 47 , , PUNCT fnp-3682 43 48 paris paris PROPN fnp-3682 43 49 , , PUNCT fnp-3682 43 50 france france PROPN fnp-3682 43 51 canvas canvas NOUN fnp-3682 43 52 is be AUX fnp-3682 43 53 a a DET fnp-3682 43 54 rare rare ADJ fnp-3682 43 55 disease disease NOUN fnp-3682 43 56 characterized characterize VERB fnp-3682 43 57 by by ADP fnp-3682 43 58 an an DET fnp-3682 43 59 intronic intronic ADJ fnp-3682 43 60 biallelic biallelic PROPN fnp-3682 43 61 aaggg aaggg NOUN fnp-3682 43 62 expansion expansion NOUN fnp-3682 43 63 in in ADP fnp-3682 43 64 rfc1 rfc1 PROPN fnp-3682 43 65 . . PUNCT fnp-3682 44 1 we we PRON fnp-3682 44 2 report report VERB fnp-3682 44 3 the the DET fnp-3682 44 4 case case NOUN fnp-3682 44 5 of of ADP fnp-3682 44 6 a a DET fnp-3682 44 7 74 74 NUM fnp-3682 44 8 - - PUNCT fnp-3682 44 9 year year NOUN fnp-3682 44 10 - - PUNCT fnp-3682 44 11 old old ADJ fnp-3682 44 12 man man NOUN fnp-3682 44 13 who who PRON fnp-3682 44 14 presented present VERB fnp-3682 44 15 with with ADP fnp-3682 44 16 cramps cramp NOUN fnp-3682 44 17 , , PUNCT fnp-3682 44 18 mixed mixed ADJ fnp-3682 44 19 sensory sensory ADJ fnp-3682 44 20 and and CCONJ fnp-3682 44 21 cerebellar cerebellar ADJ fnp-3682 44 22 ataxia ataxia NOUN fnp-3682 44 23 , , PUNCT fnp-3682 44 24 vestibular vestibular ADJ fnp-3682 44 25 areflexia areflexia NOUN fnp-3682 44 26 and and CCONJ fnp-3682 44 27 neuropathic neuropathic ADJ fnp-3682 44 28 pain pain NOUN fnp-3682 44 29 in in ADP fnp-3682 44 30 addition addition NOUN fnp-3682 44 31 to to ADP fnp-3682 44 32 parkinsonian parkinsonian ADJ fnp-3682 44 33 symptoms symptom NOUN fnp-3682 44 34 . . PUNCT fnp-3682 45 1 macroscopic macroscopic ADJ fnp-3682 45 2 examination examination NOUN fnp-3682 45 3 showed show VERB fnp-3682 45 4 atrophy atrophy NOUN fnp-3682 45 5 of of ADP fnp-3682 45 6 the the DET fnp-3682 45 7 cerebellar cerebellar ADJ fnp-3682 45 8 vermis vermis NOUN fnp-3682 45 9 and and CCONJ fnp-3682 45 10 pallor pallor NOUN fnp-3682 45 11 and and CCONJ fnp-3682 45 12 atrophy atrophy NOUN fnp-3682 45 13 of of ADP fnp-3682 45 14 the the DET fnp-3682 45 15 posterior posterior ADJ fnp-3682 45 16 columns column NOUN fnp-3682 45 17 . . PUNCT fnp-3682 46 1 microscopic microscopic ADJ fnp-3682 46 2 examination examination NOUN fnp-3682 46 3 revealed reveal VERB fnp-3682 46 4 , , PUNCT fnp-3682 46 5 in in ADP fnp-3682 46 6 addition addition NOUN fnp-3682 46 7 to to PART fnp-3682 46 8 diffuse diffuse VERB fnp-3682 46 9 lewy lewy ADJ fnp-3682 46 10 body body NOUN fnp-3682 46 11 pathology pathology NOUN fnp-3682 46 12 , , PUNCT fnp-3682 46 13 axonal axonal ADJ fnp-3682 46 14 loss loss NOUN fnp-3682 46 15 in in ADP fnp-3682 46 16 the the DET fnp-3682 46 17 dorsal dorsal NOUN fnp-3682 46 18 columns column NOUN fnp-3682 46 19 and and CCONJ fnp-3682 46 20 a a DET fnp-3682 46 21 moderate moderate ADJ fnp-3682 46 22 loss loss NOUN fnp-3682 46 23 of of ADP fnp-3682 46 24 purkinje purkinje PROPN fnp-3682 46 25 cells cell NOUN fnp-3682 46 26 in in ADP fnp-3682 46 27 the the DET fnp-3682 46 28 cerebellum cerebellum NOUN fnp-3682 46 29 . . PUNCT fnp-3682 47 1 there there PRON fnp-3682 47 2 was be AUX fnp-3682 47 3 marked mark VERB fnp-3682 47 4 astrocytic astrocytic ADJ fnp-3682 47 5 gliosis gliosis NOUN fnp-3682 47 6 in in ADP fnp-3682 47 7 contact contact NOUN fnp-3682 47 8 with with ADP fnp-3682 47 9 the the DET fnp-3682 47 10 dendrites dendrite NOUN fnp-3682 47 11 in in ADP fnp-3682 47 12 the the DET fnp-3682 47 13 spinal spinal ADJ fnp-3682 47 14 cord cord NOUN fnp-3682 47 15 and and CCONJ fnp-3682 47 16 molecular molecular ADJ fnp-3682 47 17 layer layer NOUN fnp-3682 47 18 of of ADP fnp-3682 47 19 the the DET fnp-3682 47 20 cerebellum cerebellum NOUN fnp-3682 47 21 as as ADV fnp-3682 47 22 well well ADV fnp-3682 47 23 as as ADP fnp-3682 47 24 disorganization disorganization NOUN fnp-3682 47 25 of of ADP fnp-3682 47 26 the the DET fnp-3682 47 27 radial radial ADJ fnp-3682 47 28 glia glia NOUN fnp-3682 47 29 in in ADP fnp-3682 47 30 the the DET fnp-3682 47 31 cerebellum cerebellum NOUN fnp-3682 47 32 . . PUNCT fnp-3682 48 1 we we PRON fnp-3682 48 2 report report VERB fnp-3682 48 3 the the DET fnp-3682 48 4 first first ADJ fnp-3682 48 5 complete complete ADJ fnp-3682 48 6 neuropathological neuropathological ADJ fnp-3682 48 7 examination examination NOUN fnp-3682 48 8 of of ADP fnp-3682 48 9 the the DET fnp-3682 48 10 brain brain NOUN fnp-3682 48 11 and and CCONJ fnp-3682 48 12 spinal spinal ADJ fnp-3682 48 13 cord cord NOUN fnp-3682 48 14 of of ADP fnp-3682 48 15 an an DET fnp-3682 48 16 rfc1 rfc1 ADJ fnp-3682 48 17 patient patient NOUN fnp-3682 48 18 and and CCONJ fnp-3682 48 19 describe describe VERB fnp-3682 48 20 astrocytic astrocytic ADJ fnp-3682 48 21 abnormalities abnormality NOUN fnp-3682 48 22 that that PRON fnp-3682 48 23 would would AUX fnp-3682 48 24 explain explain VERB fnp-3682 48 25 the the DET fnp-3682 48 26 severe severe ADJ fnp-3682 48 27 clinical clinical ADJ fnp-3682 48 28 phenotype phenotype NOUN fnp-3682 48 29 in in ADP fnp-3682 48 30 the the DET fnp-3682 48 31 absence absence NOUN fnp-3682 48 32 of of ADP fnp-3682 48 33 severe severe ADJ fnp-3682 48 34 neuronal neuronal ADJ fnp-3682 48 35 loss loss NOUN fnp-3682 48 36 . . PUNCT fnp-3682 48 37         SPACE fnp-3682 49 1 free free ADJ fnp-3682 49 2 neuropathol neuropathol NOUN fnp-3682 49 3 2:32:9 2:32:9 NUM fnp-3682 49 4 neuropathological neuropathological ADJ fnp-3682 49 5 and and CCONJ fnp-3682 49 6 amyloid amyloid NOUN fnp-3682 49 7 peptide peptide NOUN fnp-3682 49 8 differences difference NOUN fnp-3682 49 9 between between ADP fnp-3682 49 10 down down ADP fnp-3682 49 11 syndrome syndrome NOUN fnp-3682 49 12 and and CCONJ fnp-3682 49 13 familial familial ADJ fnp-3682 49 14 alzheimer alzheimer PROPN fnp-3682 49 15 ’s ’s PART fnp-3682 49 16 disease disease NOUN fnp-3682 49 17 with with ADP fnp-3682 49 18 duplications duplication NOUN fnp-3682 49 19 and and CCONJ fnp-3682 49 20 missense missense VERB fnp-3682 49 21 mutations mutation NOUN fnp-3682 49 22 in in ADP fnp-3682 49 23 app app PROPN fnp-3682 49 24 gene gene NOUN fnp-3682 49 25 amal amal PROPN fnp-3682 49 26 kasri1 kasri1 PROPN fnp-3682 49 27 , , PUNCT fnp-3682 49 28 léa léa PROPN fnp-3682 49 29 durix1 durix1 NOUN fnp-3682 49 30 , , PUNCT fnp-3682 49 31 susana susana PROPN fnp-3682 49 32 boluda1,2 boluda1,2 PROPN fnp-3682 49 33 , , PUNCT fnp-3682 49 34 lev lev ADJ fnp-3682 49 35 stimmer1 stimmer1 NOUN fnp-3682 49 36 , , PUNCT fnp-3682 49 37 eleni eleni PROPN fnp-3682 49 38 . . PUNCT fnp-3682 50 1 gkanatsiou3 gkanatsiou3 PROPN fnp-3682 50 2 , , PUNCT fnp-3682 50 3 gunnar gunnar PROPN fnp-3682 50 4 brinkmalm3 brinkmalm3 PROPN fnp-3682 50 5 , , PUNCT fnp-3682 50 6 yannick yannick PROPN fnp-3682 50 7 vermeiren4,5 vermeiren4,5 PROPN fnp-3682 50 8 , , PUNCT fnp-3682 50 9 sarah sarah PROPN fnp-3682 50 10 e. e. PROPN fnp-3682 51 1 pape6 pape6 PROPN fnp-3682 51 2 , , PUNCT fnp-3682 51 3 peter peter PROPN fnp-3682 51 4 p. p. PROPN fnp-3682 51 5 de de PROPN fnp-3682 51 6 deyn4,5 deyn4,5 PROPN fnp-3682 51 7 , , PUNCT fnp-3682 51 8 charles charles PROPN fnp-3682 51 9 duyckaerts1,2 duyckaerts1,2 PROPN fnp-3682 51 10 , , PUNCT fnp-3682 51 11 henrik henrik PROPN fnp-3682 51 12 zetterberg3,7 zetterberg3,7 PROPN fnp-3682 51 13 , , PUNCT fnp-3682 51 14 andre andre PROPN fnp-3682 51 15 strydom6 strydom6 PROPN fnp-3682 51 16 , , PUNCT fnp-3682 51 17 marie marie PROPN fnp-3682 51 18 - - PUNCT fnp-3682 51 19 claude claude PROPN fnp-3682 51 20 potier1 potier1 NOUN fnp-3682 51 21 1 1 NUM fnp-3682 51 22 paris paris PROPN fnp-3682 51 23 brain brain PROPN fnp-3682 51 24 institute institute PROPN fnp-3682 51 25 , , PUNCT fnp-3682 51 26 icm icm PROPN fnp-3682 51 27 , , PUNCT fnp-3682 51 28 cnrs cnrs NOUN fnp-3682 51 29 umr7225 umr7225 ADJ fnp-3682 51 30 inserm inserm PROPN fnp-3682 51 31 u1127 u1127 PROPN fnp-3682 51 32 – – PUNCT fnp-3682 51 33 upmc upmc PROPN fnp-3682 51 34 , , PUNCT fnp-3682 51 35 paris paris PROPN fnp-3682 51 36 , , PUNCT fnp-3682 51 37 france france PROPN fnp-3682 51 38 2 2 NUM fnp-3682 51 39 laboratoire laboratoire X fnp-3682 51 40 de de PROPN fnp-3682 51 41 neuropathologie neuropathologie PROPN fnp-3682 51 42 r r PROPN fnp-3682 51 43 escourolle escourolle NOUN fnp-3682 51 44 , , PUNCT fnp-3682 51 45 hôpital hôpital PROPN fnp-3682 51 46 de de PROPN fnp-3682 51 47 la la PROPN fnp-3682 51 48 pitié pitié PROPN fnp-3682 51 49 - - PUNCT fnp-3682 51 50 salpêtrière salpêtrière PROPN fnp-3682 51 51 , , PUNCT fnp-3682 51 52 ap ap PROPN fnp-3682 51 53 - - PUNCT fnp-3682 51 54 hp hp PROPN fnp-3682 51 55 , , PUNCT fnp-3682 51 56 paris paris PROPN fnp-3682 51 57 , , PUNCT fnp-3682 51 58 france france PROPN fnp-3682 51 59 3 3 NUM fnp-3682 51 60 institute institute PROPN fnp-3682 51 61 of of ADP fnp-3682 51 62 neuroscience neuroscience NOUN fnp-3682 51 63 and and CCONJ fnp-3682 51 64 physiology physiology NOUN fnp-3682 51 65 , , PUNCT fnp-3682 51 66 the the DET fnp-3682 51 67 sahlgrenska sahlgrenska PROPN fnp-3682 51 68 academy academy NOUN fnp-3682 51 69 at at ADP fnp-3682 51 70 the the DET fnp-3682 51 71 university university PROPN fnp-3682 51 72 of of ADP fnp-3682 51 73 gothenburg gothenburg PROPN fnp-3682 51 74 , , PUNCT fnp-3682 51 75 gothenburg gothenburg PROPN fnp-3682 51 76 , , PUNCT fnp-3682 51 77 sweden sweden PROPN fnp-3682 51 78 4 4 NUM fnp-3682 51 79 department department NOUN fnp-3682 51 80 of of ADP fnp-3682 51 81 biomedical biomedical ADJ fnp-3682 51 82 sciences science NOUN fnp-3682 51 83 , , PUNCT fnp-3682 51 84 neurochemistry neurochemistry NOUN fnp-3682 51 85 and and CCONJ fnp-3682 51 86 behavior behavior PROPN fnp-3682 51 87 , , PUNCT fnp-3682 51 88 institute institute NOUN fnp-3682 51 89 born bear VERB fnp-3682 51 90 - - PUNCT fnp-3682 51 91 bunge bunge NOUN fnp-3682 51 92 , , PUNCT fnp-3682 51 93 university university PROPN fnp-3682 51 94 of of ADP fnp-3682 51 95 antwerp antwerp PROPN fnp-3682 51 96 , , PUNCT fnp-3682 51 97 antwerp antwerp PROPN fnp-3682 51 98 , , PUNCT fnp-3682 51 99 belgium belgium PROPN fnp-3682 51 100 5 5 NUM fnp-3682 51 101 department department PROPN fnp-3682 51 102 of of ADP fnp-3682 51 103 neurology neurology NOUN fnp-3682 51 104 and and CCONJ fnp-3682 51 105 alzheimer alzheimer PROPN fnp-3682 51 106 center center NOUN fnp-3682 51 107 , , PUNCT fnp-3682 51 108 university university NOUN fnp-3682 51 109 of of ADP fnp-3682 51 110 groningen groningen PROPN fnp-3682 51 111 , , PUNCT fnp-3682 51 112 university university NOUN fnp-3682 51 113 medical medical ADJ fnp-3682 51 114 center center NOUN fnp-3682 51 115 groningen groningen PROPN fnp-3682 51 116 ( ( PUNCT fnp-3682 51 117 umcg umcg PROPN fnp-3682 51 118 ) ) PUNCT fnp-3682 51 119 , , PUNCT fnp-3682 51 120 groningen groningen PROPN fnp-3682 51 121 , , PUNCT fnp-3682 51 122 netherlands netherlands PROPN fnp-3682 51 123 6 6 NUM fnp-3682 51 124 institute institute PROPN fnp-3682 51 125 of of ADP fnp-3682 51 126 psychology psychology NOUN fnp-3682 51 127 and and CCONJ fnp-3682 51 128 neuroscience neuroscience NOUN fnp-3682 51 129 , , PUNCT fnp-3682 51 130 king king NOUN fnp-3682 51 131 ’s ’s PART fnp-3682 51 132 college college PROPN fnp-3682 51 133 london london PROPN fnp-3682 51 134 , , PUNCT fnp-3682 51 135 16 16 NUM fnp-3682 51 136 de de PROPN fnp-3682 51 137 crespigny crespigny PROPN fnp-3682 51 138 park park PROPN fnp-3682 51 139 , , PUNCT fnp-3682 51 140 london london PROPN fnp-3682 51 141 , , PUNCT fnp-3682 51 142 united united PROPN fnp-3682 51 143 kingdom kingdom PROPN fnp-3682 51 144 7 7 NUM fnp-3682 51 145 sahlgrenska sahlgrenska PROPN fnp-3682 51 146 university university NOUN fnp-3682 51 147 hospital hospital NOUN fnp-3682 51 148 , , PUNCT fnp-3682 51 149 clinical clinical ADJ fnp-3682 51 150 neurochemistry neurochemistry PROPN fnp-3682 51 151 laboratory laboratory NOUN fnp-3682 51 152 , , PUNCT fnp-3682 51 153 mölndal mölndal PROPN fnp-3682 51 154 , , PUNCT fnp-3682 51 155 sweden sweden PROPN fnp-3682 51 156 cerebral cerebral ADJ fnp-3682 51 157 amyloid amyloid NOUN fnp-3682 51 158 angiopathy angiopathy ADJ fnp-3682 51 159 ( ( PUNCT fnp-3682 51 160 caa caa NOUN fnp-3682 51 161 ) ) PUNCT fnp-3682 51 162 is be AUX fnp-3682 51 163 present present ADJ fnp-3682 51 164 in in ADP fnp-3682 51 165 80 80 NUM fnp-3682 51 166 % % NOUN fnp-3682 51 167 of of ADP fnp-3682 51 168 alzheimer alzheimer PROPN fnp-3682 51 169 's 's PART fnp-3682 51 170 disease disease NOUN fnp-3682 51 171 ( ( PUNCT fnp-3682 51 172 ad ad NOUN fnp-3682 51 173 ) ) PUNCT fnp-3682 51 174 patients patient NOUN fnp-3682 51 175 . . PUNCT fnp-3682 52 1 however however ADV fnp-3682 52 2 , , PUNCT fnp-3682 52 3 caa caa PROPN fnp-3682 52 4 is be AUX fnp-3682 52 5 more more ADV fnp-3682 52 6 prominent prominent ADJ fnp-3682 52 7 in in ADP fnp-3682 52 8 familial familial ADJ fnp-3682 52 9 cases case NOUN fnp-3682 52 10 with with ADP fnp-3682 52 11 app app NOUN fnp-3682 52 12 mutations mutation NOUN fnp-3682 52 13 or or CCONJ fnp-3682 52 14 duplications duplication NOUN fnp-3682 52 15 ( ( PUNCT fnp-3682 52 16 dupapp dupapp NOUN fnp-3682 52 17 ) ) PUNCT fnp-3682 52 18 and and CCONJ fnp-3682 52 19 in in ADP fnp-3682 52 20 individuals individual NOUN fnp-3682 52 21 with with ADP fnp-3682 52 22 down down ADP fnp-3682 52 23 syndrome syndrome NOUN fnp-3682 52 24 ( ( PUNCT fnp-3682 52 25 ds ds NOUN fnp-3682 52 26 ) ) PUNCT fnp-3682 52 27 . . PUNCT fnp-3682 53 1 in in ADP fnp-3682 53 2 order order NOUN fnp-3682 53 3 to to PART fnp-3682 53 4 explain explain VERB fnp-3682 53 5 these these DET fnp-3682 53 6 differences difference NOUN fnp-3682 53 7 , , PUNCT fnp-3682 53 8 we we PRON fnp-3682 53 9 investigated investigate VERB fnp-3682 53 10 the the DET fnp-3682 53 11 alterations alteration NOUN fnp-3682 53 12 in in ADP fnp-3682 53 13 the the DET fnp-3682 53 14 endo endo NOUN fnp-3682 53 15 - - PUNCT fnp-3682 53 16 lysosomal lysosomal ADJ fnp-3682 53 17 pathway pathway NOUN fnp-3682 53 18 , , PUNCT fnp-3682 53 19 aβ aβ DET fnp-3682 53 20 species specie NOUN fnp-3682 53 21 and and CCONJ fnp-3682 53 22 caa caa NOUN fnp-3682 53 23 grading grade VERB fnp-3682 53 24 in in ADP fnp-3682 53 25 post post ADJ fnp-3682 53 26 - - ADJ fnp-3682 53 27 mortem mortem ADJ fnp-3682 53 28 human human ADJ fnp-3682 53 29 brain brain NOUN fnp-3682 53 30 tissues tissue NOUN fnp-3682 53 31 . . PUNCT fnp-3682 54 1 using use VERB fnp-3682 54 2 immunohistochemistry immunohistochemistry NOUN fnp-3682 54 3 , , PUNCT fnp-3682 54 4 we we PRON fnp-3682 54 5 identified identify VERB fnp-3682 54 6 increased increase VERB fnp-3682 54 7 rab5 rab5 NOUN fnp-3682 54 8 puncta puncta NOUN fnp-3682 54 9 size size NOUN fnp-3682 54 10 in in ADP fnp-3682 54 11 all all DET fnp-3682 54 12 cases case NOUN fnp-3682 54 13 except except SCONJ fnp-3682 54 14 those those PRON fnp-3682 54 15 with with ADP fnp-3682 54 16 app app NOUN fnp-3682 54 17 mutations mutation NOUN fnp-3682 54 18 compared compare VERB fnp-3682 54 19 to to ADP fnp-3682 54 20 controls control NOUN fnp-3682 54 21 . . PUNCT fnp-3682 55 1 moreover moreover ADV fnp-3682 55 2 , , PUNCT fnp-3682 55 3 we we PRON fnp-3682 55 4 found find VERB fnp-3682 55 5 elevated elevated ADJ fnp-3682 55 6 levels level NOUN fnp-3682 55 7 of of ADP fnp-3682 55 8 aβ40 aβ40 PROPN fnp-3682 55 9 but but CCONJ fnp-3682 55 10 not not PART fnp-3682 55 11 aβ42 aβ42 PROPN fnp-3682 55 12 in in ADP fnp-3682 55 13 dupapp dupapp NOUN fnp-3682 55 14 and and CCONJ fnp-3682 55 15 in in ADP fnp-3682 55 16 ds ds PRON fnp-3682 55 17 correlating correlate VERB fnp-3682 55 18 with with ADP fnp-3682 55 19 caa caa NOUN fnp-3682 55 20 grading grade VERB fnp-3682 55 21 . . PUNCT fnp-3682 56 1 altogether altogether ADV fnp-3682 56 2 , , PUNCT fnp-3682 56 3 these these DET fnp-3682 56 4 results result NOUN fnp-3682 56 5 suggest suggest VERB fnp-3682 56 6 that that SCONJ fnp-3682 56 7 caa caa NOUN fnp-3682 56 8 arises arise VERB fnp-3682 56 9 from from ADP fnp-3682 56 10 specific specific ADJ fnp-3682 56 11 accumulation accumulation NOUN fnp-3682 56 12 of of ADP fnp-3682 56 13 aβ40 aβ40 PROPN fnp-3682 56 14 species specie NOUN fnp-3682 56 15 or or CCONJ fnp-3682 56 16 , , PUNCT fnp-3682 56 17 alternatively alternatively ADV fnp-3682 56 18 , , PUNCT fnp-3682 56 19 that that SCONJ fnp-3682 56 20 aβ40 aβ40 PROPN fnp-3682 56 21 is be AUX fnp-3682 56 22 the the DET fnp-3682 56 23 principal principal NOUN fnp-3682 56 24 aβ aβ DET fnp-3682 56 25 species specie NOUN fnp-3682 56 26 produced produce VERB fnp-3682 56 27 in in ADP fnp-3682 56 28 dupapp dupapp NOUN fnp-3682 56 29 and and CCONJ fnp-3682 56 30 ds ds VERB fnp-3682 56 31 and and CCONJ fnp-3682 56 32 is be AUX fnp-3682 56 33 more more ADV fnp-3682 56 34 prone prone ADJ fnp-3682 56 35 to to ADP fnp-3682 56 36 aggregation aggregation NOUN fnp-3682 56 37 in in ADP fnp-3682 56 38 blood blood NOUN fnp-3682 56 39 vessels vessel NOUN fnp-3682 56 40 . . PUNCT fnp-3682 57 1 the the DET fnp-3682 57 2 ongoing ongoing ADJ fnp-3682 57 3 aβ aβ NOUN fnp-3682 57 4 and and CCONJ fnp-3682 57 5 caa caa NOUN fnp-3682 57 6 grading grade VERB fnp-3682 57 7 analysis analysis NOUN fnp-3682 57 8 aim aim VERB fnp-3682 57 9 to to PART fnp-3682 57 10 unravel unravel VERB fnp-3682 57 11 pathophysiological pathophysiological ADJ fnp-3682 57 12 mechanisms mechanism NOUN fnp-3682 57 13 involved involve VERB fnp-3682 57 14 in in ADP fnp-3682 57 15 specific specific ADJ fnp-3682 57 16 aβ aβ NOUN fnp-3682 57 17 production production NOUN fnp-3682 57 18 and and CCONJ fnp-3682 57 19 deposits deposit NOUN fnp-3682 57 20 . . PUNCT fnp-3682 57 21         SPACE fnp-3682 58 1 free free ADJ fnp-3682 58 2 neuropathol neuropathol NOUN fnp-3682 58 3 2:32:10 2:32:10 NUM fnp-3682 58 4 characterization characterization NOUN fnp-3682 58 5 of of ADP fnp-3682 58 6 the the DET fnp-3682 58 7 endolysosomal endolysosomal ADJ fnp-3682 58 8 compartment compartment NOUN fnp-3682 58 9 of of ADP fnp-3682 58 10 noradrenergic noradrenergic ADJ fnp-3682 58 11 neurons neuron NOUN fnp-3682 58 12 of of ADP fnp-3682 58 13 the the DET fnp-3682 58 14 locus locus ADJ fnp-3682 58 15 cœruleus cœruleus NOUN fnp-3682 58 16 in in ADP fnp-3682 58 17 neurodegenerative neurodegenerative ADJ fnp-3682 58 18 diseases disease NOUN fnp-3682 58 19 marta marta PROPN fnp-3682 58 20 fructuoso1 fructuoso1 PROPN fnp-3682 58 21 , , PUNCT fnp-3682 58 22 susana susana PROPN fnp-3682 58 23 boluda1,2 boluda1,2 PROPN fnp-3682 58 24 , , PUNCT fnp-3682 58 25 lev lev ADJ fnp-3682 58 26 stimmer1 stimmer1 NOUN fnp-3682 58 27 , , PUNCT fnp-3682 58 28 yannick yannick PROPN fnp-3682 58 29 vermeiren3 vermeiren3 PROPN fnp-3682 58 30 , , PUNCT fnp-3682 58 31 peter peter PROPN fnp-3682 58 32 p. p. PROPN fnp-3682 58 33 de de PROPN fnp-3682 58 34 deyn3 deyn3 PROPN fnp-3682 58 35 , , PUNCT fnp-3682 58 36 debby debby PROPN fnp-3682 58 37 van van PROPN fnp-3682 58 38 dam3 dam3 PROPN fnp-3682 58 39 , , PUNCT fnp-3682 58 40 andre andre PROPN fnp-3682 58 41 strydom4 strydom4 PROPN fnp-3682 58 42 , , PUNCT fnp-3682 58 43 charles charles PROPN fnp-3682 58 44 duyckaerts1,2 duyckaerts1,2 PROPN fnp-3682 58 45 , , PUNCT fnp-3682 58 46 marie marie PROPN fnp-3682 58 47 - - PUNCT fnp-3682 58 48 claude claude PROPN fnp-3682 58 49 potier1 potier1 NOUN fnp-3682 58 50 1 1 NUM fnp-3682 58 51 icm icm PROPN fnp-3682 58 52 institut institut PROPN fnp-3682 58 53 du du PROPN fnp-3682 58 54 cerveau cerveau PROPN fnp-3682 58 55 et et PROPN fnp-3682 58 56 de de PROPN fnp-3682 58 57 la la X fnp-3682 58 58 moelle moelle PROPN fnp-3682 58 59 épinière épinière NOUN fnp-3682 58 60 , , PUNCT fnp-3682 58 61 cnrs cnrs NOUN fnp-3682 58 62 umr7225 umr7225 ADV fnp-3682 58 63 , , PUNCT fnp-3682 58 64 inserm inserm VERB fnp-3682 58 65 u1127 u1127 PROPN fnp-3682 58 66 , , PUNCT fnp-3682 58 67 upmc upmc PROPN fnp-3682 58 68 , , PUNCT fnp-3682 58 69 hôpital hôpital PROPN fnp-3682 58 70 de de PROPN fnp-3682 58 71 la la PROPN fnp-3682 58 72 pitié pitié PROPN fnp-3682 58 73 - - PUNCT fnp-3682 58 74 salpêtrière salpêtrière PROPN fnp-3682 58 75 , , PUNCT fnp-3682 58 76 47 47 NUM fnp-3682 58 77 bd bd PROPN fnp-3682 58 78 de de PROPN fnp-3682 58 79 l’hôpital l’hôpital PROPN fnp-3682 58 80 , , PUNCT fnp-3682 58 81 paris paris PROPN fnp-3682 58 82 , , PUNCT fnp-3682 58 83 france france PROPN fnp-3682 58 84 2 2 NUM fnp-3682 58 85 laboratoire laboratoire X fnp-3682 58 86 de de PROPN fnp-3682 58 87 neuropathologie neuropathologie PROPN fnp-3682 58 88 r r PROPN fnp-3682 58 89 escourolle escourolle NOUN fnp-3682 58 90 , , PUNCT fnp-3682 58 91 hôpital hôpital PROPN fnp-3682 58 92 de de PROPN fnp-3682 58 93 la la PROPN fnp-3682 58 94 pitié pitié PROPN fnp-3682 58 95 - - PUNCT fnp-3682 58 96 salpêtrière salpêtrière PROPN fnp-3682 58 97 , , PUNCT fnp-3682 58 98 ap ap PROPN fnp-3682 58 99 - - PUNCT fnp-3682 58 100 hp hp PROPN fnp-3682 58 101 , , PUNCT fnp-3682 58 102 75013 75013 NUM fnp-3682 58 103 paris paris PROPN fnp-3682 58 104 , , PUNCT fnp-3682 58 105 france france PROPN fnp-3682 58 106 3 3 NUM fnp-3682 58 107 department department PROPN fnp-3682 58 108 of of ADP fnp-3682 58 109 neurology neurology NOUN fnp-3682 58 110 and and CCONJ fnp-3682 58 111 alzheimer alzheimer PROPN fnp-3682 58 112 center center NOUN fnp-3682 58 113 , , PUNCT fnp-3682 58 114 university university NOUN fnp-3682 58 115 medical medical ADJ fnp-3682 58 116 center center NOUN fnp-3682 58 117 groningen groningen PROPN fnp-3682 58 118 , , PUNCT fnp-3682 58 119 university university NOUN fnp-3682 58 120 of of ADP fnp-3682 58 121 groningen groningen PROPN fnp-3682 58 122 , , PUNCT fnp-3682 58 123 groningen groningen PROPN fnp-3682 58 124 , , PUNCT fnp-3682 58 125 the the DET fnp-3682 58 126 netherlands netherlands PROPN fnp-3682 58 127 . . PUNCT fnp-3682 59 1 laboratory laboratory NOUN fnp-3682 59 2 of of ADP fnp-3682 59 3 neurochemistry neurochemistry NOUN fnp-3682 59 4 and and CCONJ fnp-3682 59 5 behavior behavior NOUN fnp-3682 59 6 , , PUNCT fnp-3682 59 7 department department NOUN fnp-3682 59 8 of of ADP fnp-3682 59 9 biomedical biomedical ADJ fnp-3682 59 10 sciences sciences PROPN fnp-3682 59 11 , , PUNCT fnp-3682 59 12 institute institute NOUN fnp-3682 59 13 born bear VERB fnp-3682 59 14 - - PUNCT fnp-3682 59 15 bunge bunge NOUN fnp-3682 59 16 , , PUNCT fnp-3682 59 17 university university PROPN fnp-3682 59 18 of of ADP fnp-3682 59 19 antwerp antwerp PROPN fnp-3682 59 20 , , PUNCT fnp-3682 59 21 antwerp antwerp PROPN fnp-3682 59 22 , , PUNCT fnp-3682 59 23 belgium belgium PROPN fnp-3682 59 24 4 4 NUM fnp-3682 59 25 department department NOUN fnp-3682 59 26 of of ADP fnp-3682 59 27 forensic forensic ADJ fnp-3682 59 28 and and CCONJ fnp-3682 59 29 neurodevelopmental neurodevelopmental ADJ fnp-3682 59 30 sciences sciences PROPN fnp-3682 59 31 , , PUNCT fnp-3682 59 32 institute institute NOUN fnp-3682 59 33 of of ADP fnp-3682 59 34 psychiatry psychiatry NOUN fnp-3682 59 35 , , PUNCT fnp-3682 59 36 psychology psychology NOUN fnp-3682 59 37 & & CCONJ fnp-3682 59 38 neuroscience neuroscience NOUN fnp-3682 59 39 , , PUNCT fnp-3682 59 40 king king NOUN fnp-3682 59 41 's 's PART fnp-3682 59 42 college college PROPN fnp-3682 59 43 london london PROPN fnp-3682 59 44 , , PUNCT fnp-3682 59 45 london london PROPN fnp-3682 59 46 , , PUNCT fnp-3682 59 47 uk uk PROPN fnp-3682 59 48 degeneration degeneration NOUN fnp-3682 59 49 of of ADP fnp-3682 59 50 the the DET fnp-3682 59 51 locus locus ADJ fnp-3682 59 52 coeruleus coeruleus NOUN fnp-3682 59 53 ( ( PUNCT fnp-3682 59 54 lc lc NOUN fnp-3682 59 55 ) ) PUNCT fnp-3682 59 56 is be AUX fnp-3682 59 57 a a DET fnp-3682 59 58 common common ADJ fnp-3682 59 59 feature feature NOUN fnp-3682 59 60 in in ADP fnp-3682 59 61 parkinson parkinson NOUN fnp-3682 59 62 's 's PART fnp-3682 59 63 disease disease NOUN fnp-3682 59 64 ( ( PUNCT fnp-3682 59 65 pd pd NOUN fnp-3682 59 66 ) ) PUNCT fnp-3682 59 67 , , PUNCT fnp-3682 59 68 alzheimer alzheimer PROPN fnp-3682 59 69 's 's PART fnp-3682 59 70 disease disease NOUN fnp-3682 59 71 ( ( PUNCT fnp-3682 59 72 ad ad NOUN fnp-3682 59 73 ) ) PUNCT fnp-3682 59 74 , , PUNCT fnp-3682 59 75 and and CCONJ fnp-3682 59 76 down down ADP fnp-3682 59 77 syndrome syndrome NOUN fnp-3682 59 78 ( ( PUNCT fnp-3682 59 79 ds ds NOUN fnp-3682 59 80 ) ) PUNCT fnp-3682 59 81 . . PUNCT fnp-3682 60 1 lc lc PROPN fnp-3682 60 2 is be AUX fnp-3682 60 3 the the DET fnp-3682 60 4 main main ADJ fnp-3682 60 5 source source NOUN fnp-3682 60 6 of of ADP fnp-3682 60 7 noradrenaline noradrenaline NOUN fnp-3682 60 8 in in ADP fnp-3682 60 9 the the DET fnp-3682 60 10 brain brain NOUN fnp-3682 60 11 , , PUNCT fnp-3682 60 12 and and CCONJ fnp-3682 60 13 neuronal neuronal ADJ fnp-3682 60 14 loss loss NOUN fnp-3682 60 15 in in ADP fnp-3682 60 16 this this DET fnp-3682 60 17 nucleus nucleus NOUN fnp-3682 60 18 is be AUX fnp-3682 60 19 associated associate VERB fnp-3682 60 20 with with ADP fnp-3682 60 21 dementia dementia NOUN fnp-3682 60 22 . . PUNCT fnp-3682 61 1 endolysosomal endolysosomal ADJ fnp-3682 61 2 abnormalities abnormality NOUN fnp-3682 61 3 may may AUX fnp-3682 61 4 contribute contribute VERB fnp-3682 61 5 to to ADP fnp-3682 61 6 the the DET fnp-3682 61 7 accumulation accumulation NOUN fnp-3682 61 8 of of ADP fnp-3682 61 9 toxic toxic ADJ fnp-3682 61 10 proteins protein NOUN fnp-3682 61 11 . . PUNCT fnp-3682 62 1 we we PRON fnp-3682 62 2 hypothesize hypothesize VERB fnp-3682 62 3 that that SCONJ fnp-3682 62 4 this this PRON fnp-3682 62 5 could could AUX fnp-3682 62 6 be be AUX fnp-3682 62 7 one one NUM fnp-3682 62 8 mechanism mechanism NOUN fnp-3682 62 9 of of ADP fnp-3682 62 10 lc lc PROPN fnp-3682 62 11 neurons neuron NOUN fnp-3682 62 12 vulnerability vulnerability NOUN fnp-3682 62 13 ( ( PUNCT fnp-3682 62 14 jpnd jpnd NOUN fnp-3682 62 15 - - PUNCT fnp-3682 62 16 heroes hero NOUN fnp-3682 62 17 , , PUNCT fnp-3682 62 18 www.heroes-jpnd.eu www.heroes-jpnd.eu NOUN fnp-3682 62 19 ) ) PUNCT fnp-3682 62 20 . . PUNCT fnp-3682 63 1 using use VERB fnp-3682 63 2 post post ADJ fnp-3682 63 3 - - ADJ fnp-3682 63 4 mortem mortem ADJ fnp-3682 63 5 paraffin paraffin NOUN fnp-3682 63 6 fixed fix VERB fnp-3682 63 7 lc lc PROPN fnp-3682 63 8 of of ADP fnp-3682 63 9 control control NOUN fnp-3682 63 10 and and CCONJ fnp-3682 63 11 pathological pathological ADJ fnp-3682 63 12 cases case NOUN fnp-3682 63 13 , , PUNCT fnp-3682 63 14 we we PRON fnp-3682 63 15 confirm confirm VERB fnp-3682 63 16 the the DET fnp-3682 63 17 presence presence NOUN fnp-3682 63 18 of of ADP fnp-3682 63 19 aβ aβ DET fnp-3682 63 20 plaques plaque NOUN fnp-3682 63 21 and and CCONJ fnp-3682 63 22 p p NOUN fnp-3682 63 23 - - PUNCT fnp-3682 63 24 tau tau NOUN fnp-3682 63 25 in in ADP fnp-3682 63 26 ad ad NOUN fnp-3682 63 27 and and CCONJ fnp-3682 63 28 ds ds ADJ fnp-3682 63 29 brains brain NOUN fnp-3682 63 30 , , PUNCT fnp-3682 63 31 and and CCONJ fnp-3682 63 32 lewy lewy PROPN fnp-3682 63 33 bodies body NOUN fnp-3682 63 34 in in ADP fnp-3682 63 35 pd pd NOUN fnp-3682 63 36 samples sample NOUN fnp-3682 63 37 . . PUNCT fnp-3682 64 1 analysis analysis NOUN fnp-3682 64 2 of of ADP fnp-3682 64 3 confocal confocal ADJ fnp-3682 64 4 microscopy microscopy NOUN fnp-3682 64 5 images image NOUN fnp-3682 64 6 of of ADP fnp-3682 64 7 immunofluorescence immunofluorescence NOUN fnp-3682 64 8 revealed reveal VERB fnp-3682 64 9 that that SCONJ fnp-3682 64 10 area area NOUN fnp-3682 64 11 of of ADP fnp-3682 64 12 the the DET fnp-3682 64 13 rab5 rab5 NOUN fnp-3682 64 14 positive positive ADJ fnp-3682 64 15 puncta puncta NOUN fnp-3682 64 16 of of ADP fnp-3682 64 17 endosomes endosome NOUN fnp-3682 64 18 was be AUX fnp-3682 64 19 increased increase VERB fnp-3682 64 20 in in ADP fnp-3682 64 21 ad ad NOUN fnp-3682 64 22 whereas whereas SCONJ fnp-3682 64 23 the the DET fnp-3682 64 24 area area NOUN fnp-3682 64 25 cathepsin cathepsin VERB fnp-3682 64 26 b b PROPN fnp-3682 64 27 positive positive ADJ fnp-3682 64 28 puncta puncta NOUN fnp-3682 64 29 of of ADP fnp-3682 64 30 lysosomes lysosome NOUN fnp-3682 64 31 was be AUX fnp-3682 64 32 reduced reduce VERB fnp-3682 64 33 in in ADP fnp-3682 64 34 pd pd PROPN fnp-3682 64 35 . . PUNCT fnp-3682 65 1 our our PRON fnp-3682 65 2 results result NOUN fnp-3682 65 3 suggest suggest VERB fnp-3682 65 4 that that SCONJ fnp-3682 65 5 endolysosomal endolysosomal ADJ fnp-3682 65 6 alterations alteration NOUN fnp-3682 65 7 could could AUX fnp-3682 65 8 be be AUX fnp-3682 65 9 a a DET fnp-3682 65 10 mechanism mechanism NOUN fnp-3682 65 11 implicated implicate VERB fnp-3682 65 12 in in ADP fnp-3682 65 13 the the DET fnp-3682 65 14 degeneration degeneration NOUN fnp-3682 65 15 of of ADP fnp-3682 65 16 noradrenergic noradrenergic ADJ fnp-3682 65 17 neurons neuron NOUN fnp-3682 65 18 , , PUNCT fnp-3682 65 19 and and CCONJ fnp-3682 65 20 might might AUX fnp-3682 65 21 be be AUX fnp-3682 65 22 disorder disorder NOUN fnp-3682 65 23 - - PUNCT fnp-3682 65 24 specific specific ADJ fnp-3682 65 25 . . PUNCT fnp-3682 65 26         SPACE fnp-3682 65 27 free free ADJ fnp-3682 65 28 neuropathol neuropathol NOUN fnp-3682 65 29 2:32:11 2:32:11 NUM fnp-3682 65 30 - - SYM fnp-3682 65 31 12 12 NUM fnp-3682 65 32 neuropathology neuropathology NOUN fnp-3682 65 33 analysis analysis NOUN fnp-3682 65 34 as as ADP fnp-3682 65 35 a a DET fnp-3682 65 36 precious precious ADJ fnp-3682 65 37 tool tool NOUN fnp-3682 65 38 to to PART fnp-3682 65 39 ascertain ascertain VERB fnp-3682 65 40 the the DET fnp-3682 65 41 pathogenicity pathogenicity NOUN fnp-3682 65 42 of of ADP fnp-3682 65 43 nearsplice nearsplice NOUN fnp-3682 65 44 / / SYM fnp-3682 65 45 intronic intronic ADJ fnp-3682 65 46 variants variant NOUN fnp-3682 65 47 in in ADP fnp-3682 65 48 amyotrophic amyotrophic ADJ fnp-3682 65 49 lateral lateral ADJ fnp-3682 65 50 sclerosis sclerosis NOUN fnp-3682 65 51 : : PUNCT fnp-3682 65 52 example example NOUN fnp-3682 65 53 of of ADP fnp-3682 65 54 a a DET fnp-3682 65 55 sod1 sod1 ADJ fnp-3682 65 56 nearsplice nearsplice NOUN fnp-3682 65 57 / / SYM fnp-3682 65 58 intronic intronic ADJ fnp-3682 65 59 mutation mutation NOUN fnp-3682 65 60 françois françois PROPN fnp-3682 65 61 muratet1 muratet1 PROPN fnp-3682 65 62 , , PUNCT fnp-3682 65 63 elisa elisa PROPN fnp-3682 65 64 teyssou1 teyssou1 PROPN fnp-3682 65 65 , , PUNCT fnp-3682 65 66 aude aude PROPN fnp-3682 65 67 chiot1 chiot1 PROPN fnp-3682 65 68 , , PUNCT fnp-3682 65 69 séverine séverine NOUN fnp-3682 65 70 boillée1 boillée1 NOUN fnp-3682 65 71 , , PUNCT fnp-3682 65 72 christian christian PROPN fnp-3682 65 73 s. s. PROPN fnp-3682 65 74 lobsiger1 lobsiger1 PROPN fnp-3682 65 75 , , PUNCT fnp-3682 65 76 delphine delphine PROPN fnp-3682 65 77 bohl1 bohl1 PROPN fnp-3682 65 78 , , PUNCT fnp-3682 65 79 beata beata PROPN fnp-3682 65 80 gyorgy1 gyorgy1 PROPN fnp-3682 65 81 , , PUNCT fnp-3682 65 82 justine justine PROPN fnp-3682 65 83 guegan1 guegan1 PROPN fnp-3682 65 84 , , PUNCT fnp-3682 65 85 yannick yannick PROPN fnp-3682 65 86 marie1 marie1 PROPN fnp-3682 65 87 , , PUNCT fnp-3682 65 88 maria maria PROPN fnp-3682 65 89 - - PUNCT fnp-3682 65 90 del del PROPN fnp-3682 65 91 - - PROPN fnp-3682 65 92 mar mar PROPN fnp-3682 65 93 amador1,2 amador1,2 PROPN fnp-3682 65 94 , , PUNCT fnp-3682 65 95 françois françois PROPN fnp-3682 65 96 salachas1,2 salachas1,2 PROPN fnp-3682 65 97 , , PUNCT fnp-3682 65 98 vincent vincent NOUN fnp-3682 65 99 meininger3 meininger3 PROPN fnp-3682 65 100 , , PUNCT fnp-3682 65 101 emilien emilien NOUN fnp-3682 65 102 bernard4,5 bernard4,5 PROPN fnp-3682 65 103 , , PUNCT fnp-3682 65 104 jean jean PROPN fnp-3682 65 105 - - PUNCT fnp-3682 65 106 christophe christophe PROPN fnp-3682 65 107 antoine6 antoine6 PROPN fnp-3682 65 108 , , PUNCT fnp-3682 65 109 jean jean PROPN fnp-3682 65 110 - - PUNCT fnp-3682 65 111 philippe philippe PROPN fnp-3682 65 112 camdessanché6 camdessanché6 PROPN fnp-3682 65 113 , , PUNCT fnp-3682 65 114 william william PROPN fnp-3682 65 115 camu7 camu7 PROPN fnp-3682 65 116 , , PUNCT fnp-3682 65 117 cécile cécile PROPN fnp-3682 65 118 cazeneuve8 cazeneuve8 PROPN fnp-3682 65 119 , , PUNCT fnp-3682 65 120 anne anne PROPN fnp-3682 65 121 - - PUNCT fnp-3682 65 122 laure laure PROPN fnp-3682 65 123 fauret fauret PROPN fnp-3682 65 124 - - PUNCT fnp-3682 65 125 amsellem8 amsellem8 NOUN fnp-3682 65 126 , , PUNCT fnp-3682 65 127 eric eric PROPN fnp-3682 65 128 leguern1,8 leguern1,8 PROPN fnp-3682 65 129 , , PUNCT fnp-3682 65 130 kevin kevin PROPN fnp-3682 65 131 mouzat9 mouzat9 PROPN fnp-3682 65 132 , , PUNCT fnp-3682 65 133 claire claire PROPN fnp-3682 65 134 guissart9 guissart9 PROPN fnp-3682 65 135 , , PUNCT fnp-3682 65 136 serge serge PROPN fnp-3682 65 137 lumbroso9 lumbroso9 PROPN fnp-3682 65 138 , , PUNCT fnp-3682 65 139 philippe philippe PROPN fnp-3682 65 140 corcia10,11 corcia10,11 PROPN fnp-3682 65 141 , , PUNCT fnp-3682 65 142 patrick patrick PROPN fnp-3682 65 143 vourc’h11,12 vourc’h11,12 PROPN fnp-3682 65 144 , , PUNCT fnp-3682 65 145 aude aude PROPN fnp-3682 65 146 - - PROPN fnp-3682 65 147 marie marie PROPN fnp-3682 65 148 grapperon13 grapperon13 PROPN fnp-3682 65 149 , , PUNCT fnp-3682 65 150 shahram shahram PROPN fnp-3682 65 151 attarian13 attarian13 PROPN fnp-3682 65 152 , , PUNCT fnp-3682 65 153 annie annie PROPN fnp-3682 65 154 verschueren13 verschueren13 NOUN fnp-3682 65 155 , , PUNCT fnp-3682 65 156 danielle danielle PROPN fnp-3682 65 157 seilhean1,14 seilhean1,14 AUX fnp-3682 65 158 * * PUNCT fnp-3682 65 159 and and CCONJ fnp-3682 65 160 stéphanie stéphanie PROPN fnp-3682 65 161 millecamps1 millecamps1 PROPN fnp-3682 65 162 * * PROPN fnp-3682 65 163 1 1 NUM fnp-3682 65 164 cm cm NOUN fnp-3682 65 165 , , PUNCT fnp-3682 65 166 institut institut PROPN fnp-3682 65 167 du du PROPN fnp-3682 65 168 cerveau cerveau PROPN fnp-3682 65 169 , , PUNCT fnp-3682 65 170 inserm inserm VERB fnp-3682 65 171 u1127 u1127 PROPN fnp-3682 65 172 , , PUNCT fnp-3682 65 173 cnrs cnrs VERB fnp-3682 65 174 umr7225 umr7225 ADV fnp-3682 65 175 , , PUNCT fnp-3682 65 176 sorbonne sorbonne PROPN fnp-3682 65 177 université université PROPN fnp-3682 65 178 , , PUNCT fnp-3682 65 179 paris paris PROPN fnp-3682 65 180 , , PUNCT fnp-3682 65 181 france france PROPN fnp-3682 65 182 2 2 NUM fnp-3682 65 183 ap ap PROPN fnp-3682 65 184 - - PUNCT fnp-3682 65 185 hp hp PROPN fnp-3682 65 186 , , PUNCT fnp-3682 65 187 département département X fnp-3682 65 188 de de X fnp-3682 65 189 neurologie neurologie X fnp-3682 65 190 , , PUNCT fnp-3682 65 191 centre centre NOUN fnp-3682 65 192 de de X fnp-3682 65 193 référence référence PROPN fnp-3682 65 194 sla sla PROPN fnp-3682 65 195 ile ile PROPN fnp-3682 65 196 de de PROPN fnp-3682 65 197 france france PROPN fnp-3682 65 198 , , PUNCT fnp-3682 65 199 hôpital hôpital PROPN fnp-3682 65 200 de de PROPN fnp-3682 65 201 la la PROPN fnp-3682 65 202 pitié pitié PROPN fnp-3682 65 203 - - PUNCT fnp-3682 65 204 salpêtrière salpêtrière PROPN fnp-3682 65 205 , , PUNCT fnp-3682 65 206 paris paris PROPN fnp-3682 65 207 , , PUNCT fnp-3682 65 208 france france PROPN fnp-3682 65 209 3 3 NUM fnp-3682 65 210 hôpital hôpital PROPN fnp-3682 65 211 des des PROPN fnp-3682 65 212 peupliers peupliers PROPN fnp-3682 65 213 , , PUNCT fnp-3682 65 214 ramsay ramsay PROPN fnp-3682 65 215 générale générale X fnp-3682 65 216 de de X fnp-3682 65 217 santé santé X fnp-3682 65 218 , , PUNCT fnp-3682 65 219 paris paris PROPN fnp-3682 65 220 , , PUNCT fnp-3682 65 221 france france PROPN fnp-3682 65 222 4 4 NUM fnp-3682 65 223 centre centre NOUN fnp-3682 65 224 de de X fnp-3682 65 225 référence référence NOUN fnp-3682 65 226 sla sla PROPN fnp-3682 65 227 , , PUNCT fnp-3682 65 228 hôpital hôpital ADJ fnp-3682 65 229 neurologique neurologique PROPN fnp-3682 65 230 pierre pierre PROPN fnp-3682 65 231 wertheimer wertheimer PROPN fnp-3682 65 232 , , PUNCT fnp-3682 65 233 hospices hospice VERB fnp-3682 65 234 civils civils PROPN fnp-3682 65 235 de de PROPN fnp-3682 65 236 lyon lyon PROPN fnp-3682 65 237 , , PUNCT fnp-3682 65 238 université université PROPN fnp-3682 65 239 de de PROPN fnp-3682 65 240 lyon lyon PROPN fnp-3682 65 241 , , PUNCT fnp-3682 65 242 bron bron PROPN fnp-3682 65 243 , , PUNCT fnp-3682 65 244 france france PROPN fnp-3682 65 245 5 5 NUM fnp-3682 65 246 institut institut PROPN fnp-3682 65 247 neuromyogène neuromyogène PROPN fnp-3682 65 248 , , PUNCT fnp-3682 65 249 cnrs cnrs NOUN fnp-3682 65 250 umr5310 umr5310 NOUN fnp-3682 65 251 , , PUNCT fnp-3682 65 252 inserm inserm NOUN fnp-3682 65 253 u1217 u1217 NOUN fnp-3682 65 254 , , PUNCT fnp-3682 65 255 faculté faculté PROPN fnp-3682 65 256 de de X fnp-3682 65 257 médecine médecine PROPN fnp-3682 65 258 rockefeller rockefeller NOUN fnp-3682 65 259 , , PUNCT fnp-3682 65 260 université université PROPN fnp-3682 65 261 claude claude PROPN fnp-3682 65 262 bernard bernard PROPN fnp-3682 65 263 lyon lyon PROPN fnp-3682 65 264 i i PROPN fnp-3682 65 265 , , PUNCT fnp-3682 65 266 lyon lyon PROPN fnp-3682 65 267 , , PUNCT fnp-3682 65 268 france france PROPN fnp-3682 65 269 6 6 NUM fnp-3682 65 270 service service NOUN fnp-3682 65 271 de de X fnp-3682 65 272 neurologie neurologie X fnp-3682 65 273 , , PUNCT fnp-3682 65 274 centre centre NOUN fnp-3682 65 275 de de X fnp-3682 65 276 ressource ressource PROPN fnp-3682 65 277 et et PROPN fnp-3682 65 278 de de PROPN fnp-3682 65 279 compétence compétence PROPN fnp-3682 65 280 sla sla PROPN fnp-3682 65 281 , , PUNCT fnp-3682 65 282 hôpital hôpital PROPN fnp-3682 65 283 nord nord PROPN fnp-3682 65 284 , , PUNCT fnp-3682 65 285 chu chu PROPN fnp-3682 65 286 de de PROPN fnp-3682 65 287 saint saint PROPN fnp-3682 65 288 - - PUNCT fnp-3682 65 289 etienne etienne PROPN fnp-3682 65 290 , , PUNCT fnp-3682 65 291 saint saint PROPN fnp-3682 65 292 - - PUNCT fnp-3682 65 293 etienne etienne PROPN fnp-3682 65 294 , , PUNCT fnp-3682 65 295 france france PROPN fnp-3682 65 296 7 7 NUM fnp-3682 65 297 centre centre NOUN fnp-3682 65 298 de de X fnp-3682 65 299 référence référence NOUN fnp-3682 65 300 sla sla PROPN fnp-3682 65 301 , , PUNCT fnp-3682 65 302 hôpital hôpital PROPN fnp-3682 65 303 gui gui PROPN fnp-3682 65 304 de de PROPN fnp-3682 65 305 chauliac chauliac PROPN fnp-3682 65 306 , , PUNCT fnp-3682 65 307 chu chu PROPN fnp-3682 65 308 et et PROPN fnp-3682 65 309 université université PROPN fnp-3682 65 310 de de PROPN fnp-3682 65 311 montpellier montpellier NOUN fnp-3682 65 312 , , PUNCT fnp-3682 65 313 montpellier montpellier NOUN fnp-3682 65 314 , , PUNCT fnp-3682 65 315 france france PROPN fnp-3682 65 316 8 8 NUM fnp-3682 65 317 département département X fnp-3682 65 318 de de X fnp-3682 65 319 génétique génétique X fnp-3682 65 320 et et PROPN fnp-3682 65 321 cytogénétique cytogénétique NOUN fnp-3682 65 322 , , PUNCT fnp-3682 65 323 unité unité NOUN fnp-3682 65 324 fonctionnelle fonctionnelle NOUN fnp-3682 65 325 de de ADP fnp-3682 65 326 neurogénétique neurogénétique NOUN fnp-3682 65 327 moléculaire moléculaire NOUN fnp-3682 65 328 et et PROPN fnp-3682 65 329 cellulaire cellulaire PROPN fnp-3682 65 330 , , PUNCT fnp-3682 65 331 aphp aphp ADJ fnp-3682 65 332 , , PUNCT fnp-3682 65 333 hôpital hôpital ADJ fnp-3682 65 334 pitié pitié PROPN fnp-3682 65 335 - - PUNCT fnp-3682 65 336 salpêtrière salpêtrière PROPN fnp-3682 65 337 , , PUNCT fnp-3682 65 338 paris paris PROPN fnp-3682 65 339 , , PUNCT fnp-3682 65 340 france france PROPN fnp-3682 65 341 9 9 NUM fnp-3682 65 342 laboratoire laboratoire PROPN fnp-3682 65 343 de de PROPN fnp-3682 65 344 biochimie biochimie PROPN fnp-3682 65 345 et et PROPN fnp-3682 65 346 biologie biologie PROPN fnp-3682 65 347 moleculaire moleculaire PROPN fnp-3682 65 348 , , PUNCT fnp-3682 65 349 chu chu PROPN fnp-3682 65 350 nimes nime NOUN fnp-3682 65 351 , , PUNCT fnp-3682 65 352 nîmes nîme NOUN fnp-3682 65 353 , , PUNCT fnp-3682 65 354 motoneuron motoneuron NOUN fnp-3682 65 355 disease disease NOUN fnp-3682 65 356 : : PUNCT fnp-3682 65 357 pathophysiology pathophysiology NOUN fnp-3682 65 358 and and CCONJ fnp-3682 65 359 therapy therapy NOUN fnp-3682 65 360 , , PUNCT fnp-3682 65 361 inm inm PROPN fnp-3682 65 362 , , PUNCT fnp-3682 65 363 inserm inserm PROPN fnp-3682 65 364 , , PUNCT fnp-3682 65 365 univ univ PROPN fnp-3682 65 366 . . PUNCT fnp-3682 65 367 montpellier montpellier NOUN fnp-3682 65 368 , , PUNCT fnp-3682 65 369 montpellier montpellier NOUN fnp-3682 65 370 , , PUNCT fnp-3682 65 371 france france PROPN fnp-3682 65 372 10 10 NUM fnp-3682 65 373 centre centre PROPN fnp-3682 65 374 sla sla PROPN fnp-3682 65 375 , , PUNCT fnp-3682 65 376 chu chu PROPN fnp-3682 65 377 tours tour NOUN fnp-3682 65 378 , , PUNCT fnp-3682 65 379 tours tour NOUN fnp-3682 65 380 , , PUNCT fnp-3682 65 381 france france PROPN fnp-3682 65 382 11 11 NUM fnp-3682 65 383 umr umr ADP fnp-3682 65 384 1253 1253 NUM fnp-3682 65 385 , , PUNCT fnp-3682 65 386 université université PROPN fnp-3682 65 387 de de PROPN fnp-3682 65 388 tours tour NOUN fnp-3682 65 389 , , PUNCT fnp-3682 65 390 inserm inserm NOUN fnp-3682 65 391 , , PUNCT fnp-3682 65 392 tours tour NOUN fnp-3682 65 393 , , PUNCT fnp-3682 65 394 france france PROPN fnp-3682 65 395 12 12 NUM fnp-3682 65 396 service service NOUN fnp-3682 65 397 de de ADP fnp-3682 65 398 biochimie biochimie X fnp-3682 65 399 et et PROPN fnp-3682 65 400 biologie biologie PROPN fnp-3682 65 401 moléculaire moléculaire PROPN fnp-3682 65 402 , , PUNCT fnp-3682 65 403 chu chu PROPN fnp-3682 65 404 tours tour NOUN fnp-3682 65 405 , , PUNCT fnp-3682 65 406 tours tour NOUN fnp-3682 65 407 , , PUNCT fnp-3682 65 408 france france PROPN fnp-3682 65 409 13 13 NUM fnp-3682 65 410 centre centre NOUN fnp-3682 65 411 de de X fnp-3682 65 412 référence référence NOUN fnp-3682 65 413 pour pour NOUN fnp-3682 65 414 les les PROPN fnp-3682 65 415 maladies malady NOUN fnp-3682 65 416 neuromusculaire neuromusculaire ADV fnp-3682 65 417 et et PROPN fnp-3682 65 418 la la PROPN fnp-3682 65 419 sla sla PROPN fnp-3682 65 420 , , PUNCT fnp-3682 65 421 chu chu PROPN fnp-3682 65 422 de de X fnp-3682 65 423 marseille marseille PROPN fnp-3682 65 424 , , PUNCT fnp-3682 65 425 hôpital hôpital PROPN fnp-3682 65 426 de de X fnp-3682 65 427 la la PROPN fnp-3682 65 428 timone timone PROPN fnp-3682 65 429 , , PUNCT fnp-3682 65 430 marseille marseille PROPN fnp-3682 65 431 , , PUNCT fnp-3682 65 432 france france PROPN fnp-3682 65 433 14 14 NUM fnp-3682 65 434 ap ap PROPN fnp-3682 65 435 - - PUNCT fnp-3682 65 436 hp hp PROPN fnp-3682 65 437 , , PUNCT fnp-3682 65 438 département département X fnp-3682 65 439 de de X fnp-3682 65 440 neuropathologie neuropathologie NOUN fnp-3682 65 441 , , PUNCT fnp-3682 65 442 hôpital hôpital ADJ fnp-3682 65 443 pitié pitié PROPN fnp-3682 65 444 - - PUNCT fnp-3682 65 445 salpêtrière salpêtrière PROPN fnp-3682 65 446 , , PUNCT fnp-3682 65 447 paris paris PROPN fnp-3682 65 448 , , PUNCT fnp-3682 65 449 france france PROPN fnp-3682 65 450 * * PUNCT fnp-3682 65 451 equal equal ADJ fnp-3682 65 452 contribution contribution NOUN fnp-3682 65 453 among among ADP fnp-3682 65 454 etiologic etiologic ADJ fnp-3682 65 455 factors factor NOUN fnp-3682 65 456 assumed assume VERB fnp-3682 65 457 to to PART fnp-3682 65 458 be be AUX fnp-3682 65 459 responsible responsible ADJ fnp-3682 65 460 of of ADP fnp-3682 65 461 amyotrophic amyotrophic ADJ fnp-3682 65 462 lateral lateral ADJ fnp-3682 65 463 sclerosis sclerosis NOUN fnp-3682 65 464 ( ( PUNCT fnp-3682 65 465 als als NOUN fnp-3682 65 466 ) ) PUNCT fnp-3682 65 467 , , PUNCT fnp-3682 65 468 several several ADJ fnp-3682 65 469 plausible plausible ADJ fnp-3682 65 470 causative causative ADJ fnp-3682 65 471 genes gene NOUN fnp-3682 65 472 have have AUX fnp-3682 65 473 emerged emerge VERB fnp-3682 65 474 . . PUNCT fnp-3682 66 1 it it PRON fnp-3682 66 2 becomes become VERB fnp-3682 66 3 crucial crucial ADJ fnp-3682 66 4 to to PART fnp-3682 66 5 determine determine VERB fnp-3682 66 6 the the DET fnp-3682 66 7 pathogenicity pathogenicity NOUN fnp-3682 66 8 of of ADP fnp-3682 66 9 any any DET fnp-3682 66 10 genetic genetic ADJ fnp-3682 66 11 variant variant NOUN fnp-3682 66 12 identified identify VERB fnp-3682 66 13 through through ADP fnp-3682 66 14 whole whole ADJ fnp-3682 66 15 exome exome NOUN fnp-3682 66 16 / / SYM fnp-3682 66 17 genome genome NOUN fnp-3682 66 18 sequencing sequencing NOUN fnp-3682 66 19 analysis analysis NOUN fnp-3682 66 20 , , PUNCT fnp-3682 66 21 including include VERB fnp-3682 66 22 those those PRON fnp-3682 66 23 located locate VERB fnp-3682 66 24 in in ADP fnp-3682 66 25 non non ADJ fnp-3682 66 26 - - ADJ fnp-3682 66 27 coding coding ADJ fnp-3682 66 28 regions region NOUN fnp-3682 66 29 . . PUNCT fnp-3682 67 1 we we PRON fnp-3682 67 2 describe describe VERB fnp-3682 67 3 a a DET fnp-3682 67 4 c.358 c.358 NOUN fnp-3682 67 5 - - NOUN fnp-3682 67 6 10t 10t NOUN fnp-3682 67 7 > > SYM fnp-3682 67 8 g g NOUN fnp-3682 67 9 nearsplice nearsplice NOUN fnp-3682 67 10 / / SYM fnp-3682 67 11 intronic intronic ADJ fnp-3682 67 12 variant variant NOUN fnp-3682 67 13 in in ADP fnp-3682 67 14 the the DET fnp-3682 67 15 sod1 sod1 ADJ fnp-3682 67 16 gene gene NOUN fnp-3682 67 17 , , PUNCT fnp-3682 67 18 encoding encode VERB fnp-3682 67 19 superoxide superoxide NOUN fnp-3682 67 20 dismutase dismutase NOUN fnp-3682 67 21 1 1 NUM fnp-3682 67 22 , , PUNCT fnp-3682 67 23 as as ADP fnp-3682 67 24 the the DET fnp-3682 67 25 second second ADJ fnp-3682 67 26 prominent prominent ADJ fnp-3682 67 27 mutation mutation NOUN fnp-3682 67 28 among among ADP fnp-3682 67 29 the the DET fnp-3682 67 30 sod1 sod1 ADV fnp-3682 67 31 related relate VERB fnp-3682 67 32 - - PUNCT fnp-3682 67 33 french french NOUN fnp-3682 67 34 als als NOUN fnp-3682 67 35 families family NOUN fnp-3682 67 36 . . PUNCT fnp-3682 68 1 this this DET fnp-3682 68 2 variant variant NOUN fnp-3682 68 3 leads lead VERB fnp-3682 68 4 to to ADP fnp-3682 68 5 the the DET fnp-3682 68 6 addition addition NOUN fnp-3682 68 7 of of ADP fnp-3682 68 8 three three NUM fnp-3682 68 9 amino amino ADJ fnp-3682 68 10 acids acid NOUN fnp-3682 68 11 in in ADP fnp-3682 68 12 the the DET fnp-3682 68 13 protein protein NOUN fnp-3682 68 14 sequence sequence NOUN fnp-3682 68 15 and and CCONJ fnp-3682 68 16 impairs impair VERB fnp-3682 68 17 the the DET fnp-3682 68 18 protein protein NOUN fnp-3682 68 19 secondary secondary ADJ fnp-3682 68 20 structure structure NOUN fnp-3682 68 21 . . PUNCT fnp-3682 69 1 biochemical biochemical ADJ fnp-3682 69 2 and and CCONJ fnp-3682 69 3 neuropathological neuropathological ADJ fnp-3682 69 4 analyses analysis NOUN fnp-3682 69 5 performed perform VERB fnp-3682 69 6 on on ADP fnp-3682 69 7 patient patient ADJ fnp-3682 69 8 tissue tissue NOUN fnp-3682 69 9 revealed reveal VERB fnp-3682 69 10 massive massive ADJ fnp-3682 69 11 cytoplasmic cytoplasmic ADJ fnp-3682 69 12 sod1 sod1 ADJ fnp-3682 69 13 and and CCONJ fnp-3682 69 14 neurofilament neurofilament ADJ fnp-3682 69 15 accumulation accumulation NOUN fnp-3682 69 16 in in ADP fnp-3682 69 17 spinal spinal ADJ fnp-3682 69 18 motor motor NOUN fnp-3682 69 19 neurons neuron NOUN fnp-3682 69 20 , , PUNCT fnp-3682 69 21 similar similar ADJ fnp-3682 69 22 to to ADP fnp-3682 69 23 those those PRON fnp-3682 69 24 observed observe VERB fnp-3682 69 25 in in ADP fnp-3682 69 26 spinal spinal ADJ fnp-3682 69 27 cord cord NOUN fnp-3682 69 28 of of ADP fnp-3682 69 29 patients patient NOUN fnp-3682 69 30 with with ADP fnp-3682 69 31 d83 d83 PROPN fnp-3682 69 32 g g PROPN fnp-3682 69 33 or or CCONJ fnp-3682 69 34 g93d g93d VERB fnp-3682 69 35 sod1 sod1 ADJ fnp-3682 69 36 mutations mutation NOUN fnp-3682 69 37 . . PUNCT fnp-3682 70 1 these these DET fnp-3682 70 2 neuropathology neuropathology NOUN fnp-3682 70 3 findings finding NOUN fnp-3682 70 4 ascertain ascertain VERB fnp-3682 70 5 this this DET fnp-3682 70 6 variant variant ADJ fnp-3682 70 7 pathogenicity pathogenicity NOUN fnp-3682 70 8 , , PUNCT fnp-3682 70 9 which which PRON fnp-3682 70 10 is be AUX fnp-3682 70 11 a a DET fnp-3682 70 12 crucial crucial ADJ fnp-3682 70 13 information information NOUN fnp-3682 70 14 in in ADP fnp-3682 70 15 the the DET fnp-3682 70 16 context context NOUN fnp-3682 70 17 of of ADP fnp-3682 70 18 patient patient ADJ fnp-3682 70 19 enrolment enrolment NOUN fnp-3682 70 20 in in ADP fnp-3682 70 21 ongoing ongoing ADJ fnp-3682 70 22 clinical clinical ADJ fnp-3682 70 23 trials trial NOUN fnp-3682 70 24 targeting target VERB fnp-3682 70 25 sod1 sod1 NOUN fnp-3682 70 26 by by ADP fnp-3682 70 27 antisense antisense NOUN fnp-3682 70 28 oligonucleotides oligonucleotide NOUN fnp-3682 70 29         SPACE fnp-3682 70 30 conferences conference NOUN fnp-3682 70 31 : : PUNCT fnp-3682 70 32     SPACE fnp-3682 70 33 free free ADJ fnp-3682 70 34 neuropathol neuropathol NOUN fnp-3682 70 35 2:32:13 2:32:13 NUM fnp-3682 70 36 implication implication NOUN fnp-3682 70 37 of of ADP fnp-3682 70 38 microglial microglial ADJ fnp-3682 70 39 cells cell NOUN fnp-3682 70 40 and and CCONJ fnp-3682 70 41 peripheral peripheral ADJ fnp-3682 70 42 macrophages macrophage NOUN fnp-3682 70 43 in in ADP fnp-3682 70 44 amyotrophic amyotrophic ADJ fnp-3682 70 45 lateral lateral ADJ fnp-3682 70 46 sclerosis sclerosis NOUN fnp-3682 70 47 ( ( PUNCT fnp-3682 70 48 als als NOUN fnp-3682 70 49 ) ) PUNCT fnp-3682 70 50 aude aude PROPN fnp-3682 70 51 chiot1,2 chiot1,2 PROPN fnp-3682 70 52 , , PUNCT fnp-3682 70 53 félix félix ADJ fnp-3682 70 54 berriat berriat NOUN fnp-3682 70 55 f1 f1 PROPN fnp-3682 70 56 , , PUNCT fnp-3682 70 57 matthieu matthieu PROPN fnp-3682 70 58 ribon1 ribon1 PROPN fnp-3682 70 59 , , PUNCT fnp-3682 70 60 sakina sakina PROPN fnp-3682 70 61 zaïdi1 zaïdi1 PROPN fnp-3682 70 62 , , PUNCT fnp-3682 70 63 charlène charlène PROPN fnp-3682 70 64 iltis1,3 iltis1,3 PROPN fnp-3682 70 65 , , PUNCT fnp-3682 70 66 michel michel PROPN fnp-3682 70 67 mallat1 mallat1 PROPN fnp-3682 70 68 , , PUNCT fnp-3682 70 69 delphine delphine PROPN fnp-3682 70 70 bohl1 bohl1 PROPN fnp-3682 70 71 , , PUNCT fnp-3682 70 72 stéphanie stéphanie PROPN fnp-3682 70 73 millecamps1 millecamps1 PROPN fnp-3682 70 74 , , PUNCT fnp-3682 70 75 danielle danielle PROPN fnp-3682 70 76 seilhean1,4 seilhean1,4 PROPN fnp-3682 70 77 , , PUNCT fnp-3682 70 78 christian christian PROPN fnp-3682 70 79 s s PART fnp-3682 70 80 lobsiger1 lobsiger1 NOUN fnp-3682 70 81 , , PUNCT fnp-3682 70 82 séverine séverine VERB fnp-3682 70 83 boillée1 boillée1 NOUN fnp-3682 70 84 1 1 NUM fnp-3682 70 85 sorbonne sorbonne PROPN fnp-3682 70 86 université université PROPN fnp-3682 70 87 , , PUNCT fnp-3682 70 88 institut institut PROPN fnp-3682 70 89 du du PROPN fnp-3682 70 90 cerveau cerveau PROPN fnp-3682 70 91 – – PUNCT fnp-3682 70 92 paris paris PROPN fnp-3682 70 93 brain brain PROPN fnp-3682 70 94 institute institute PROPN fnp-3682 70 95 icm icm PROPN fnp-3682 70 96 , , PUNCT fnp-3682 70 97 inserm inserm NOUN fnp-3682 70 98 , , PUNCT fnp-3682 70 99 cnrs cnrs NOUN fnp-3682 70 100 ap ap PROPN fnp-3682 70 101 - - PUNCT fnp-3682 70 102 hp hp PROPN fnp-3682 70 103 , , PUNCT fnp-3682 70 104 hôpital hôpital X fnp-3682 70 105 de de PROPN fnp-3682 70 106 la la PROPN fnp-3682 70 107 pitié pitié PROPN fnp-3682 70 108 - - PUNCT fnp-3682 70 109 salpêtrière salpêtrière PROPN fnp-3682 70 110 , , PUNCT fnp-3682 70 111 paris paris PROPN fnp-3682 70 112 , , PUNCT fnp-3682 70 113 france france PROPN fnp-3682 70 114 2 2 NUM fnp-3682 70 115 current current ADJ fnp-3682 70 116 address address NOUN fnp-3682 70 117 : : PUNCT fnp-3682 70 118 department department NOUN fnp-3682 70 119 of of ADP fnp-3682 70 120 molecular molecular ADJ fnp-3682 70 121 microbiology microbiology NOUN fnp-3682 70 122 and and CCONJ fnp-3682 70 123 immunology immunology NOUN fnp-3682 70 124 , , PUNCT fnp-3682 70 125 oregon oregon PROPN fnp-3682 70 126 health health PROPN fnp-3682 70 127 and and CCONJ fnp-3682 70 128 science science PROPN fnp-3682 70 129 university university PROPN fnp-3682 70 130 , , PUNCT fnp-3682 70 131 portland portland PROPN fnp-3682 70 132 , , PUNCT fnp-3682 70 133 or or CCONJ fnp-3682 70 134 97239 97239 NUM fnp-3682 70 135 , , PUNCT fnp-3682 70 136 usa usa PROPN fnp-3682 70 137 3 3 NUM fnp-3682 70 138 current current ADJ fnp-3682 70 139 address address NOUN fnp-3682 70 140 : : PUNCT fnp-3682 70 141 cancer cancer NOUN fnp-3682 70 142 biology biology NOUN fnp-3682 70 143 & & CCONJ fnp-3682 70 144 genetics genetics PROPN fnp-3682 70 145 program program NOUN fnp-3682 70 146 , , PUNCT fnp-3682 70 147 memorial memorial ADJ fnp-3682 70 148 sloan sloan NOUN fnp-3682 70 149 kettering kettering PROPN fnp-3682 70 150 cancer cancer PROPN fnp-3682 70 151 center center PROPN fnp-3682 70 152 , , PUNCT fnp-3682 70 153 new new PROPN fnp-3682 70 154 york york PROPN fnp-3682 70 155 , , PUNCT fnp-3682 70 156 ny ny PROPN fnp-3682 70 157 10065 10065 NUM fnp-3682 70 158 , , PUNCT fnp-3682 70 159 usa usa PROPN fnp-3682 70 160 4 4 NUM fnp-3682 70 161 département département X fnp-3682 70 162 de de X fnp-3682 70 163 neuropathologie neuropathologie NOUN fnp-3682 70 164 , , PUNCT fnp-3682 70 165 assistance assistance NOUN fnp-3682 70 166 publique publique PROPN fnp-3682 70 167 hôpitaux hôpitaux PROPN fnp-3682 70 168 de de X fnp-3682 70 169 paris paris PROPN fnp-3682 70 170 ( ( PUNCT fnp-3682 70 171 ap ap PROPN fnp-3682 70 172 - - PUNCT fnp-3682 70 173 hp hp PROPN fnp-3682 70 174 ) ) PUNCT fnp-3682 70 175 , , PUNCT fnp-3682 70 176 hôpital hôpital PROPN fnp-3682 70 177 pitié pitié PROPN fnp-3682 70 178 - - PUNCT fnp-3682 70 179 salpêtrière salpêtrière PROPN fnp-3682 70 180 , , PUNCT fnp-3682 70 181 paris paris PROPN fnp-3682 70 182 , , PUNCT fnp-3682 70 183 france france PROPN fnp-3682 70 184 in in ADP fnp-3682 70 185 mouse mouse NOUN fnp-3682 70 186 models model NOUN fnp-3682 70 187 of of ADP fnp-3682 70 188 amyotrophic amyotrophic ADJ fnp-3682 70 189 lateral lateral ADJ fnp-3682 70 190 sclerosis sclerosis NOUN fnp-3682 70 191 ( ( PUNCT fnp-3682 70 192 als als NOUN fnp-3682 70 193 ) ) PUNCT fnp-3682 70 194 , , PUNCT fnp-3682 70 195 the the DET fnp-3682 70 196 most most ADV fnp-3682 70 197 common common ADJ fnp-3682 70 198 motor motor NOUN fnp-3682 70 199 neuron neuron PROPN fnp-3682 70 200 ( ( PUNCT fnp-3682 70 201 mn mn NOUN fnp-3682 70 202 ) ) PUNCT fnp-3682 70 203 disease disease NOUN fnp-3682 70 204 of of ADP fnp-3682 70 205 the the DET fnp-3682 70 206 adult adult NOUN fnp-3682 70 207 , , PUNCT fnp-3682 70 208 microglial microglial ADJ fnp-3682 70 209 cells/ cells/ NUM fnp-3682 70 210 macrophages macrophage NOUN fnp-3682 70 211 have have AUX fnp-3682 70 212 been be AUX fnp-3682 70 213 shown show VERB fnp-3682 70 214 to to PART fnp-3682 70 215 participate participate VERB fnp-3682 70 216 to to ADP fnp-3682 70 217 disease disease NOUN fnp-3682 70 218 progression progression NOUN fnp-3682 70 219 . . PUNCT fnp-3682 71 1 however however ADV fnp-3682 71 2 , , PUNCT fnp-3682 71 3 the the DET fnp-3682 71 4 respective respective ADJ fnp-3682 71 5 contributions contribution NOUN fnp-3682 71 6 of of ADP fnp-3682 71 7 microglial microglial ADJ fnp-3682 71 8 cells cell NOUN fnp-3682 71 9 ( ( PUNCT fnp-3682 71 10 mg mg ADJ fnp-3682 71 11 ) ) PUNCT fnp-3682 71 12 and and CCONJ fnp-3682 71 13 peripheral peripheral ADJ fnp-3682 71 14 macrophages macrophage NOUN fnp-3682 71 15 ( ( PUNCT fnp-3682 71 16 pm pm NOUN fnp-3682 71 17 ) ) PUNCT fnp-3682 71 18 were be AUX fnp-3682 71 19 not not PART fnp-3682 71 20 documented document VERB fnp-3682 71 21 . . PUNCT fnp-3682 72 1 we we PRON fnp-3682 72 2 have have AUX fnp-3682 72 3 now now ADV fnp-3682 72 4 shown show VERB fnp-3682 72 5 that that SCONJ fnp-3682 72 6 pm pm NOUN fnp-3682 72 7 were be AUX fnp-3682 72 8 present present ADJ fnp-3682 72 9 around around ADP fnp-3682 72 10 mn mn PROPN fnp-3682 72 11 axons axon NOUN fnp-3682 72 12 of of ADP fnp-3682 72 13 als als NOUN fnp-3682 72 14 patients patient NOUN fnp-3682 72 15 , , PUNCT fnp-3682 72 16 both both CCONJ fnp-3682 72 17 in in ADP fnp-3682 72 18 motor motor NOUN fnp-3682 72 19 roots root NOUN fnp-3682 72 20 and and CCONJ fnp-3682 72 21 peripheral peripheral ADJ fnp-3682 72 22 nerves nerve NOUN fnp-3682 72 23 . . PUNCT fnp-3682 73 1 in in ADP fnp-3682 73 2 als als NOUN fnp-3682 73 3 mice mouse NOUN fnp-3682 73 4 , , PUNCT fnp-3682 73 5 pm pm PROPN fnp-3682 73 6 were be AUX fnp-3682 73 7 progressively progressively ADV fnp-3682 73 8 activated activate VERB fnp-3682 73 9 and and CCONJ fnp-3682 73 10 their their PRON fnp-3682 73 11 infiltration infiltration NOUN fnp-3682 73 12 into into ADP fnp-3682 73 13 the the DET fnp-3682 73 14 spinal spinal ADJ fnp-3682 73 15 cord cord NOUN fnp-3682 73 16 was be AUX fnp-3682 73 17 very very ADV fnp-3682 73 18 limited limited ADJ fnp-3682 73 19 and and CCONJ fnp-3682 73 20 disease disease NOUN fnp-3682 73 21 - - PUNCT fnp-3682 73 22 length length NOUN fnp-3682 73 23 dependent dependent ADJ fnp-3682 73 24 . . PUNCT fnp-3682 74 1 transcriptomics transcriptomic NOUN fnp-3682 74 2 analysis analysis NOUN fnp-3682 74 3 showed show VERB fnp-3682 74 4 that that SCONJ fnp-3682 74 5 mg mg PROPN fnp-3682 74 6 and and CCONJ fnp-3682 74 7 pm pm NOUN fnp-3682 74 8 reacted react VERB fnp-3682 74 9 differently differently ADV fnp-3682 74 10 to to ADP fnp-3682 74 11 mn mn PROPN fnp-3682 74 12 degeneration degeneration NOUN fnp-3682 74 13 . . PUNCT fnp-3682 75 1 replacing replace VERB fnp-3682 75 2 pm pm NOUN fnp-3682 75 3 by by ADP fnp-3682 75 4 macrophages macrophage NOUN fnp-3682 75 5 more more ADV fnp-3682 75 6 neurotrophic neurotrophic ADJ fnp-3682 75 7 , , PUNCT fnp-3682 75 8 at at ADP fnp-3682 75 9 disease disease NOUN fnp-3682 75 10 onset onset VERB fnp-3682 75 11 , , PUNCT fnp-3682 75 12 increased increase VERB fnp-3682 75 13 als als NOUN fnp-3682 75 14 mouse mouse NOUN fnp-3682 75 15 survival survival NOUN fnp-3682 75 16 and and CCONJ fnp-3682 75 17 downregulated downregulate VERB fnp-3682 75 18 not not PART fnp-3682 75 19 only only ADV fnp-3682 75 20 pm pm VERB fnp-3682 75 21 activation activation NOUN fnp-3682 75 22 in in ADP fnp-3682 75 23 peripheral peripheral ADJ fnp-3682 75 24 nerves nerve NOUN fnp-3682 75 25 but but CCONJ fnp-3682 75 26 also also ADV fnp-3682 75 27 suppressed suppress VERB fnp-3682 75 28 proinflammatory proinflammatory ADJ fnp-3682 75 29 responses response NOUN fnp-3682 75 30 of of ADP fnp-3682 75 31 mg mg PROPN fnp-3682 75 32 in in ADP fnp-3682 75 33 the the DET fnp-3682 75 34 spinal spinal NOUN fnp-3682 75 35 cord cord NOUN fnp-3682 75 36 , , PUNCT fnp-3682 75 37 with with ADP fnp-3682 75 38 a a DET fnp-3682 75 39 switch switch NOUN fnp-3682 75 40 toward toward ADP fnp-3682 75 41 neuronal neuronal ADJ fnp-3682 75 42 support support NOUN fnp-3682 75 43 . . PUNCT fnp-3682 76 1 thus thus ADV fnp-3682 76 2 , , PUNCT fnp-3682 76 3 targeting target VERB fnp-3682 76 4 pm pm NOUN fnp-3682 76 5 , , PUNCT fnp-3682 76 6 directly directly ADV fnp-3682 76 7 at at ADP fnp-3682 76 8 the the DET fnp-3682 76 9 periphery periphery NOUN fnp-3682 76 10 , , PUNCT fnp-3682 76 11 could could AUX fnp-3682 76 12 be be AUX fnp-3682 76 13 of of ADP fnp-3682 76 14 therapeutic therapeutic ADJ fnp-3682 76 15 value value NOUN fnp-3682 76 16 in in ADP fnp-3682 76 17 als al NOUN fnp-3682 76 18 . . PUNCT fnp-3682 76 19         SPACE fnp-3682 77 1 free free ADJ fnp-3682 77 2 neuropathol neuropathol NOUN fnp-3682 77 3 2:32:14 2:32:14 NUM fnp-3682 77 4 the the DET fnp-3682 77 5 neuro neuro PROPN fnp-3682 77 6 - - PUNCT fnp-3682 77 7 ceb ceb PROPN fnp-3682 77 8 brainbank brainbank NOUN fnp-3682 77 9 : : PUNCT fnp-3682 77 10 a a DET fnp-3682 77 11 brief brief ADJ fnp-3682 77 12 history history NOUN fnp-3682 77 13 ( ( PUNCT fnp-3682 77 14 15 15 NUM fnp-3682 77 15 years year NOUN fnp-3682 77 16 ! ! PUNCT fnp-3682 77 17 ) ) PUNCT fnp-3682 77 18 of of ADP fnp-3682 77 19 neuropathology neuropathology PROPN fnp-3682 77 20 marie marie PROPN fnp-3682 77 21 - - PUNCT fnp-3682 77 22 claire claire PROPN fnp-3682 77 23 artaud artaud PROPN fnp-3682 77 24 - - PUNCT fnp-3682 77 25 botté1 botté1 PROPN fnp-3682 77 26 , , PUNCT fnp-3682 77 27 sabrina sabrina PROPN fnp-3682 77 28 leclère leclère PROPN fnp-3682 77 29 - - PUNCT fnp-3682 77 30 turbant2 turbant2 ADJ fnp-3682 77 31 , , PUNCT fnp-3682 77 32 charles charles PROPN fnp-3682 77 33 duyckaerts2 duyckaerts2 PROPN fnp-3682 77 34 , , PUNCT fnp-3682 77 35 marie marie PROPN fnp-3682 77 36 laure laure PROPN fnp-3682 77 37 martin martin PROPN fnp-3682 77 38 - - PUNCT fnp-3682 77 39 négrier3 négrier3 PROPN fnp-3682 77 40 , , PUNCT fnp-3682 77 41 franck franck PROPN fnp-3682 77 42 letournel4 letournel4 PROPN fnp-3682 77 43 , , PUNCT fnp-3682 77 44 neuro neuro NOUN fnp-3682 77 45 - - PUNCT fnp-3682 77 46 ceb ceb PROPN fnp-3682 77 47 neuropathologist neuropathologist NOUN fnp-3682 77 48 ’ ' PUNCT fnp-3682 77 49 network5 network5 PROPN fnp-3682 77 50 , , PUNCT fnp-3682 77 51 isabelle isabelle PROPN fnp-3682 77 52 plu6 plu6 PROPN fnp-3682 77 53 , , PUNCT fnp-3682 77 54 susana susana PROPN fnp-3682 77 55 boluda2,6 boluda2,6 PROPN fnp-3682 77 56 , , PUNCT fnp-3682 77 57 danielle danielle PROPN fnp-3682 77 58 seilhean2,6 seilhean2,6 PROPN fnp-3682 77 59 1 1 NUM fnp-3682 77 60 association association PROPN fnp-3682 77 61 neuro neuro PROPN fnp-3682 77 62 - - PUNCT fnp-3682 77 63 ceb ceb PROPN fnp-3682 77 64 ( ( PUNCT fnp-3682 77 65 paris paris PROPN fnp-3682 77 66 , , PUNCT fnp-3682 77 67 france france PROPN fnp-3682 77 68 ): ): PUNCT fnp-3682 77 69 arsla arsla PROPN fnp-3682 77 70 , , PUNCT fnp-3682 77 71 association association PROPN fnp-3682 77 72 france france PROPN fnp-3682 77 73 dft dft PROPN fnp-3682 77 74 , , PUNCT fnp-3682 77 75 association association PROPN fnp-3682 77 76 france france PROPN fnp-3682 77 77 parkinson parkinson PROPN fnp-3682 77 78 , , PUNCT fnp-3682 77 79 csc csc PROPN fnp-3682 77 80 , , PUNCT fnp-3682 77 81 fondation fondation PROPN fnp-3682 77 82 arsep arsep PROPN fnp-3682 77 83 , , PUNCT fnp-3682 77 84 fondation fondation PROPN fnp-3682 77 85 vaincre vaincre PROPN fnp-3682 77 86 alzheimer alzheimer PROPN fnp-3682 77 87 2 2 NUM fnp-3682 77 88 icm icm PROPN fnp-3682 77 89 - - PUNCT fnp-3682 77 90 paris paris PROPN fnp-3682 77 91 brain brain PROPN fnp-3682 77 92 institute institute PROPN fnp-3682 77 93 cnrs cnrs PROPN fnp-3682 77 94 umr7225 umr7225 PROPN fnp-3682 77 95 inserm inserm PROPN fnp-3682 77 96 u1127 u1127 PROPN fnp-3682 77 97 – – PUNCT fnp-3682 77 98 sorbonne sorbonne PROPN fnp-3682 77 99 university university PROPN fnp-3682 77 100 gh gh PROPN fnp-3682 77 101 pitié pitié PROPN fnp-3682 77 102 - - PUNCT fnp-3682 77 103 salpêtrière salpêtrière PROPN fnp-3682 77 104 , , PUNCT fnp-3682 77 105 paris paris PROPN fnp-3682 77 106 france france PROPN fnp-3682 77 107 3 3 NUM fnp-3682 77 108 gh gh PROPN fnp-3682 77 109 pellegrin pellegrin NOUN fnp-3682 77 110 , , PUNCT fnp-3682 77 111 bordeaux bordeaux NOUN fnp-3682 77 112 , , PUNCT fnp-3682 77 113 france france PROPN fnp-3682 77 114 4 4 NUM fnp-3682 77 115 chu chu PROPN fnp-3682 77 116 d’angers d’angers PROPN fnp-3682 77 117 , , PUNCT fnp-3682 77 118 france france PROPN fnp-3682 77 119 5 5 NUM fnp-3682 77 120 neuro neuro PROPN fnp-3682 77 121 - - PUNCT fnp-3682 77 122 ceb ceb NOUN fnp-3682 77 123 neuropathologist neuropathologist NOUN fnp-3682 77 124 ’ ' PUNCT fnp-3682 77 125 network network NOUN fnp-3682 77 126 : : PUNCT fnp-3682 77 127 susana susana PROPN fnp-3682 77 128 boluda boluda PROPN fnp-3682 77 129 ( ( PUNCT fnp-3682 77 130 gh gh PROPN fnp-3682 77 131 pitié pitié PROPN fnp-3682 77 132 - - PUNCT fnp-3682 77 133 salpêtrière salpêtrière PROPN fnp-3682 77 134 , , PUNCT fnp-3682 77 135 paris paris PROPN fnp-3682 77 136 , , PUNCT fnp-3682 77 137 france france PROPN fnp-3682 77 138 ) ) PUNCT fnp-3682 77 139 , , PUNCT fnp-3682 77 140 jean jean PROPN fnp-3682 77 141 boutonnat boutonnat PROPN fnp-3682 77 142 ( ( PUNCT fnp-3682 77 143 hôpital hôpital PROPN fnp-3682 77 144 michalon michalon PROPN fnp-3682 77 145 , , PUNCT fnp-3682 77 146 grenoble grenoble PROPN fnp-3682 77 147 , , PUNCT fnp-3682 77 148 france france PROPN fnp-3682 77 149 ) ) PUNCT fnp-3682 77 150 , , PUNCT fnp-3682 77 151 fanny fanny NOUN fnp-3682 77 152 burel burel NOUN fnp-3682 77 153 - - PUNCT fnp-3682 77 154 vandenbos vandenbos PROPN fnp-3682 77 155 ( ( PUNCT fnp-3682 77 156 hôpital hôpital PROPN fnp-3682 77 157 pasteur pasteur PROPN fnp-3682 77 158 , , PUNCT fnp-3682 77 159 nice nice PROPN fnp-3682 77 160 , , PUNCT fnp-3682 77 161 france france PROPN fnp-3682 77 162 ) ) PUNCT fnp-3682 77 163 , , PUNCT fnp-3682 77 164 françoise françoise PROPN fnp-3682 77 165 chapon chapon PROPN fnp-3682 77 166 ( ( PUNCT fnp-3682 77 167 hôpital hôpital ADJ fnp-3682 77 168 côte côte PROPN fnp-3682 77 169 de de X fnp-3682 77 170 nacre nacre PROPN fnp-3682 77 171 , , PUNCT fnp-3682 77 172 caen caen PROPN fnp-3682 77 173 , , PUNCT fnp-3682 77 174 france france PROPN fnp-3682 77 175 ) ) PUNCT fnp-3682 77 176 , , PUNCT fnp-3682 77 177 dan dan PROPN fnp-3682 77 178 - - PUNCT fnp-3682 77 179 christian christian PROPN fnp-3682 77 180 chiforeanu chiforeanu NOUN fnp-3682 77 181 ( ( PUNCT fnp-3682 77 182 hôpital hôpital ADJ fnp-3682 77 183 pontchaillou pontchaillou PROPN fnp-3682 77 184 , , PUNCT fnp-3682 77 185 rennes renne NOUN fnp-3682 77 186 , , PUNCT fnp-3682 77 187 france france PROPN fnp-3682 77 188 ) ) PUNCT fnp-3682 77 189 , , PUNCT fnp-3682 77 190 vincent vincent PROPN fnp-3682 77 191 deramecourt deramecourt PROPN fnp-3682 77 192 ( ( PUNCT fnp-3682 77 193 chu chu PROPN fnp-3682 77 194 salengro salengro PROPN fnp-3682 77 195 , , PUNCT fnp-3682 77 196 lille lille PROPN fnp-3682 77 197 , , PUNCT fnp-3682 77 198 france france PROPN fnp-3682 77 199 ) ) PUNCT fnp-3682 77 200 , , PUNCT fnp-3682 77 201 charles charles PROPN fnp-3682 77 202 duyckaerts duyckaert NOUN fnp-3682 77 203 ( ( PUNCT fnp-3682 77 204 gh gh PROPN fnp-3682 77 205 pitié pitié PROPN fnp-3682 77 206 - - PUNCT fnp-3682 77 207 salpêtrière salpêtrière PROPN fnp-3682 77 208 , , PUNCT fnp-3682 77 209 paris paris PROPN fnp-3682 77 210 , , PUNCT fnp-3682 77 211 france france PROPN fnp-3682 77 212 ) ) PUNCT fnp-3682 77 213 , , PUNCT fnp-3682 77 214 maxime maxime NOUN fnp-3682 77 215 faisant faisant NOUN fnp-3682 77 216 ( ( PUNCT fnp-3682 77 217 hôpital hôpital ADJ fnp-3682 77 218 côte côte PROPN fnp-3682 77 219 de de X fnp-3682 77 220 nacre nacre PROPN fnp-3682 77 221 , , PUNCT fnp-3682 77 222 caen caen PROPN fnp-3682 77 223 , , PUNCT fnp-3682 77 224 france france PROPN fnp-3682 77 225 ) ) PUNCT fnp-3682 77 226 , , PUNCT fnp-3682 77 227 catherine catherine PROPN fnp-3682 77 228 godfraind godfraind PROPN fnp-3682 77 229 ( ( PUNCT fnp-3682 77 230 chu chu PROPN fnp-3682 77 231 gabriel gabriel PROPN fnp-3682 77 232 montpied montpie VERB fnp-3682 77 233 , , PUNCT fnp-3682 77 234 clermont clermont NOUN fnp-3682 77 235 - - PUNCT fnp-3682 77 236 ferrand ferrand NOUN fnp-3682 77 237 , , PUNCT fnp-3682 77 238 france france PROPN fnp-3682 77 239 ) ) PUNCT fnp-3682 77 240 , , PUNCT fnp-3682 77 241 béatrice béatrice NOUN fnp-3682 77 242 lannes lanne NOUN fnp-3682 77 243 ( ( PUNCT fnp-3682 77 244 hôpital hôpital X fnp-3682 77 245 de de X fnp-3682 77 246 hautepierre hautepierre PROPN fnp-3682 77 247 , , PUNCT fnp-3682 77 248 strasbourg strasbourg NOUN fnp-3682 77 249 , , PUNCT fnp-3682 77 250 france france PROPN fnp-3682 77 251 ) ) PUNCT fnp-3682 77 252 , , PUNCT fnp-3682 77 253 annie annie NOUN fnp-3682 77 254 laquerrière laquerrière PROPN fnp-3682 77 255 ( ( PUNCT fnp-3682 77 256 chu chu PROPN fnp-3682 77 257 charles charles PROPN fnp-3682 77 258 nicolle nicolle PROPN fnp-3682 77 259 , , PUNCT fnp-3682 77 260 rouen rouen PROPN fnp-3682 77 261 , , PUNCT fnp-3682 77 262 france france PROPN fnp-3682 77 263 ) ) PUNCT fnp-3682 77 264 , , PUNCT fnp-3682 77 265 franck franck PROPN fnp-3682 77 266 letournel letournel PROPN fnp-3682 77 267 ( ( PUNCT fnp-3682 77 268 chu chu PROPN fnp-3682 77 269 d’angers d’angers PROPN fnp-3682 77 270 , , PUNCT fnp-3682 77 271 france france PROPN fnp-3682 77 272 ) ) PUNCT fnp-3682 77 273 , , PUNCT fnp-3682 77 274 benoit benoit NOUN fnp-3682 77 275 lhermitte lhermitte PROPN fnp-3682 77 276 ( ( PUNCT fnp-3682 77 277 hôpital hôpital PROPN fnp-3682 77 278 de de X fnp-3682 77 279 hautepierre hautepierre PROPN fnp-3682 77 280 , , PUNCT fnp-3682 77 281 strasbourg strasbourg NOUN fnp-3682 77 282 , , PUNCT fnp-3682 77 283 france france PROPN fnp-3682 77 284 ) ) PUNCT fnp-3682 77 285 , , PUNCT fnp-3682 77 286 florent florent NOUN fnp-3682 77 287 marguet marguet PROPN fnp-3682 77 288 ( ( PUNCT fnp-3682 77 289 chu chu PROPN fnp-3682 77 290 charles charles PROPN fnp-3682 77 291 nicolle nicolle PROPN fnp-3682 77 292 , , PUNCT fnp-3682 77 293 rouen rouen PROPN fnp-3682 77 294 , , PUNCT fnp-3682 77 295 france france PROPN fnp-3682 77 296 ) ) PUNCT fnp-3682 77 297 , , PUNCT fnp-3682 77 298 marie marie PROPN fnp-3682 77 299 - - PUNCT fnp-3682 77 300 laure laure PROPN fnp-3682 77 301 martin martin PROPN fnp-3682 77 302 - - PUNCT fnp-3682 77 303 négrier négrier PROPN fnp-3682 77 304 ( ( PUNCT fnp-3682 77 305 gh gh PROPN fnp-3682 77 306 pellegrin pellegrin PROPN fnp-3682 77 307 , , PUNCT fnp-3682 77 308 bordeaux bordeaux NOUN fnp-3682 77 309 , , PUNCT fnp-3682 77 310 france france PROPN fnp-3682 77 311 ) ) PUNCT fnp-3682 77 312 , , PUNCT fnp-3682 77 313 andré andré VERB fnp-3682 77 314 maues maues PROPN fnp-3682 77 315 de de PROPN fnp-3682 77 316 paula paula PROPN fnp-3682 77 317 ( ( PUNCT fnp-3682 77 318 chu chu PROPN fnp-3682 77 319 timone timone NOUN fnp-3682 77 320 2 2 NUM fnp-3682 77 321 , , PUNCT fnp-3682 77 322 marseille marseille NOUN fnp-3682 77 323 , , PUNCT fnp-3682 77 324 france france PROPN fnp-3682 77 325 ) ) PUNCT fnp-3682 77 326 , , PUNCT fnp-3682 77 327 claude claude PROPN fnp-3682 77 328 - - PUNCT fnp-3682 77 329 alain alain PROPN fnp-3682 77 330 maurage maurage PROPN fnp-3682 77 331 ( ( PUNCT fnp-3682 77 332 chu chu PROPN fnp-3682 77 333 salengro salengro PROPN fnp-3682 77 334 , , PUNCT fnp-3682 77 335 lille lille PROPN fnp-3682 77 336 , , PUNCT fnp-3682 77 337 france france PROPN fnp-3682 77 338 ) ) PUNCT fnp-3682 77 339 , , PUNCT fnp-3682 77 340 david david PROPN fnp-3682 77 341 meyronet meyronet PROPN fnp-3682 77 342 ( ( PUNCT fnp-3682 77 343 hôpital hôpital ADJ fnp-3682 77 344 pierre pierre PROPN fnp-3682 77 345 wertheimer wertheimer X fnp-3682 77 346 , , PUNCT fnp-3682 77 347 lyon lyon PROPN fnp-3682 77 348 , , PUNCT fnp-3682 77 349 france france PROPN fnp-3682 77 350 ) ) PUNCT fnp-3682 77 351 , , PUNCT fnp-3682 77 352 isabelle isabelle PROPN fnp-3682 77 353 plu plu PROPN fnp-3682 77 354 ( ( PUNCT fnp-3682 77 355 gh gh PROPN fnp-3682 77 356 pitié pitié PROPN fnp-3682 77 357 - - PUNCT fnp-3682 77 358 salpêtrière salpêtrière PROPN fnp-3682 77 359 , , PUNCT fnp-3682 77 360 paris paris PROPN fnp-3682 77 361 , , PUNCT fnp-3682 77 362 france france PROPN fnp-3682 77 363 ) ) PUNCT fnp-3682 77 364 , , PUNCT fnp-3682 77 365 valérie valérie ADJ fnp-3682 77 366 rigau rigau NOUN fnp-3682 77 367 ( ( PUNCT fnp-3682 77 368 hôpital hôpital PROPN fnp-3682 77 369 gui gui PROPN fnp-3682 77 370 de de PROPN fnp-3682 77 371 chauliac chauliac PROPN fnp-3682 77 372 , , PUNCT fnp-3682 77 373 ( ( PUNCT fnp-3682 77 374 montpellier montpellier NOUN fnp-3682 77 375 , , PUNCT fnp-3682 77 376 france france PROPN fnp-3682 77 377 ) ) PUNCT fnp-3682 77 378 6 6 NUM fnp-3682 77 379 laboratoire laboratoire PROPN fnp-3682 77 380 de de X fnp-3682 77 381 neuropathologie neuropathologie NOUN fnp-3682 77 382 , , PUNCT fnp-3682 77 383 gh gh PROPN fnp-3682 77 384 pitié pitié PROPN fnp-3682 77 385 - - PUNCT fnp-3682 77 386 salpêtrière salpêtrière PROPN fnp-3682 77 387 , , PUNCT fnp-3682 77 388 ap ap PROPN fnp-3682 77 389 - - PUNCT fnp-3682 77 390 hp hp PROPN fnp-3682 77 391 - - PROPN fnp-3682 77 392 sorbonne sorbonne PROPN fnp-3682 77 393 université université PROPN fnp-3682 77 394 , , PUNCT fnp-3682 77 395 paris paris PROPN fnp-3682 77 396 , , PUNCT fnp-3682 77 397 france france PROPN fnp-3682 77 398 the the DET fnp-3682 77 399 neuro neuro PROPN fnp-3682 77 400 - - PUNCT fnp-3682 77 401 ceb ceb PROPN fnp-3682 77 402 national national ADJ fnp-3682 77 403 brainbank brainbank PROPN fnp-3682 77 404 was be AUX fnp-3682 77 405 founded found VERB fnp-3682 77 406 in in ADP fnp-3682 77 407 2006 2006 NUM fnp-3682 77 408 at at ADP fnp-3682 77 409 the the DET fnp-3682 77 410 initiative initiative NOUN fnp-3682 77 411 of of ADP fnp-3682 77 412 patients patient NOUN fnp-3682 77 413 ’ ' PUNCT fnp-3682 77 414 associations association NOUN fnp-3682 77 415 , , PUNCT fnp-3682 77 416 to to PART fnp-3682 77 417 support support VERB fnp-3682 77 418 a a DET fnp-3682 77 419 post post NOUN fnp-3682 77 420 mortem mortem X fnp-3682 77 421 brain brain NOUN fnp-3682 77 422 donation donation NOUN fnp-3682 77 423 program program NOUN fnp-3682 77 424 . . PUNCT fnp-3682 78 1 the the DET fnp-3682 78 2 missions mission NOUN fnp-3682 78 3 are be AUX fnp-3682 78 4 to to PART fnp-3682 78 5 collect collect VERB fnp-3682 78 6 , , PUNCT fnp-3682 78 7 sample sample NOUN fnp-3682 78 8 , , PUNCT fnp-3682 78 9 prepare prepare VERB fnp-3682 78 10 and and CCONJ fnp-3682 78 11 store store VERB fnp-3682 78 12 nervous nervous ADJ fnp-3682 78 13 tissues tissue NOUN fnp-3682 78 14 ( ( PUNCT fnp-3682 78 15 brain brain NOUN fnp-3682 78 16 and and CCONJ fnp-3682 78 17 spinal spinal ADJ fnp-3682 78 18 cord cord NOUN fnp-3682 78 19 ) ) PUNCT fnp-3682 78 20 , , PUNCT fnp-3682 78 21 taken take VERB fnp-3682 78 22 post post NOUN fnp-3682 78 23 mortem mortem NOUN fnp-3682 78 24 from from ADP fnp-3682 78 25 " " PUNCT fnp-3682 78 26 control control NOUN fnp-3682 78 27 " " PUNCT fnp-3682 78 28 subjects subject NOUN fnp-3682 78 29 ( ( PUNCT fnp-3682 78 30 not not PART fnp-3682 78 31 suffering suffer VERB fnp-3682 78 32 from from ADP fnp-3682 78 33 neurological neurological ADJ fnp-3682 78 34 diseases disease NOUN fnp-3682 78 35 ) ) PUNCT fnp-3682 78 36 and and CCONJ fnp-3682 78 37 from from ADP fnp-3682 78 38 patients patient NOUN fnp-3682 78 39 suffering suffer VERB fnp-3682 78 40 from from ADP fnp-3682 78 41 alzheimer alzheimer NOUN fnp-3682 78 42 or or CCONJ fnp-3682 78 43 parkinson parkinson NOUN fnp-3682 78 44 disease disease NOUN fnp-3682 78 45 , , PUNCT fnp-3682 78 46 multiple multiple ADJ fnp-3682 78 47 sclerosis sclerosis NOUN fnp-3682 78 48 , , PUNCT fnp-3682 78 49 ataxia ataxia NOUN fnp-3682 78 50 , , PUNCT fnp-3682 78 51 amyotrophic amyotrophic ADJ fnp-3682 78 52 lateral lateral ADJ fnp-3682 78 53 sclerosis sclerosis NOUN fnp-3682 78 54 , , PUNCT fnp-3682 78 55 frontotemporal frontotemporal ADJ fnp-3682 78 56 lobar lobar ADJ fnp-3682 78 57 degeneration degeneration NOUN fnp-3682 78 58 , , PUNCT fnp-3682 78 59 or or CCONJ fnp-3682 78 60 cadasil cadasil NOUN fnp-3682 78 61 . . PUNCT fnp-3682 79 1 the the DET fnp-3682 79 2 biological biological ADJ fnp-3682 79 3 ressources ressource NOUN fnp-3682 79 4 are be AUX fnp-3682 79 5 provided provide VERB fnp-3682 79 6 to to ADP fnp-3682 79 7 research research NOUN fnp-3682 79 8 teams team NOUN fnp-3682 79 9 presenting present VERB fnp-3682 79 10 a a DET fnp-3682 79 11 suitable suitable ADJ fnp-3682 79 12 project project NOUN fnp-3682 79 13 reviewed review VERB fnp-3682 79 14 by by ADP fnp-3682 79 15 a a DET fnp-3682 79 16 scientific scientific ADJ fnp-3682 79 17 committee committee NOUN fnp-3682 79 18 . . PUNCT fnp-3682 80 1 the the DET fnp-3682 80 2 organization organization NOUN fnp-3682 80 3 relies rely VERB fnp-3682 80 4 on on ADP fnp-3682 80 5 a a DET fnp-3682 80 6 network network NOUN fnp-3682 80 7 of of ADP fnp-3682 80 8 neuropathologists neuropathologist NOUN fnp-3682 80 9 from from ADP fnp-3682 80 10 14 14 NUM fnp-3682 80 11 hospitals hospital NOUN fnp-3682 80 12 . . PUNCT fnp-3682 81 1 they they PRON fnp-3682 81 2 are be AUX fnp-3682 81 3 in in ADP fnp-3682 81 4 charge charge NOUN fnp-3682 81 5 of of ADP fnp-3682 81 6 brain brain NOUN fnp-3682 81 7 sampling sampling NOUN fnp-3682 81 8 and and CCONJ fnp-3682 81 9 neuropathological neuropathological ADJ fnp-3682 81 10 diagnosis diagnosis NOUN fnp-3682 81 11 . . PUNCT fnp-3682 82 1 the the DET fnp-3682 82 2 expertise expertise NOUN fnp-3682 82 3 of of ADP fnp-3682 82 4 these these DET fnp-3682 82 5 neuropathologists neuropathologist NOUN fnp-3682 82 6 ensures ensure VERB fnp-3682 82 7 a a DET fnp-3682 82 8 high high ADJ fnp-3682 82 9 quality quality NOUN fnp-3682 82 10 of of ADP fnp-3682 82 11 the the DET fnp-3682 82 12 samples sample NOUN fnp-3682 82 13 . . PUNCT fnp-3682 83 1 their their PRON fnp-3682 83 2 involvement involvement NOUN fnp-3682 83 3 over over ADP fnp-3682 83 4 the the DET fnp-3682 83 5 past past ADJ fnp-3682 83 6 15 15 NUM fnp-3682 83 7 years year NOUN fnp-3682 83 8 alongside alongside ADP fnp-3682 83 9 research research NOUN fnp-3682 83 10 teams team NOUN fnp-3682 83 11 , , PUNCT fnp-3682 83 12 has have AUX fnp-3682 83 13 led lead VERB fnp-3682 83 14 to to ADP fnp-3682 83 15 the the DET fnp-3682 83 16 publication publication NOUN fnp-3682 83 17 of of ADP fnp-3682 83 18 more more ADJ fnp-3682 83 19 than than ADP fnp-3682 83 20 100 100 NUM fnp-3682 83 21 scientific scientific ADJ fnp-3682 83 22 articles article NOUN fnp-3682 83 23 . . PUNCT fnp-3682 84 1 this this PRON fnp-3682 84 2 illustrates illustrate VERB fnp-3682 84 3 the the DET fnp-3682 84 4 impact impact NOUN fnp-3682 84 5 of of ADP fnp-3682 84 6 the the DET fnp-3682 84 7 neuro neuro PROPN fnp-3682 84 8 - - PUNCT fnp-3682 84 9 ceb ceb PROPN fnp-3682 84 10 biobank biobank NOUN fnp-3682 84 11 at at ADP fnp-3682 84 12 an an DET fnp-3682 84 13 international international ADJ fnp-3682 84 14 level level NOUN fnp-3682 84 15 . . PUNCT fnp-3682 84 16         SPACE fnp-3682 85 1 free free ADJ fnp-3682 85 2 neuropathol neuropathol NOUN fnp-3682 85 3 2:32:15 2:32:15 NUM fnp-3682 85 4 human human ADJ fnp-3682 85 5 brain brain NOUN fnp-3682 85 6 imaging imaging NOUN fnp-3682 85 7 with with ADP fnp-3682 85 8 stochastic stochastic ADJ fnp-3682 85 9 optical optical ADJ fnp-3682 85 10 reconstruction reconstruction NOUN fnp-3682 85 11 microscopy microscopy NOUN fnp-3682 85 12 ( ( PUNCT fnp-3682 85 13 storm storm NOUN fnp-3682 85 14 ) ) PUNCT fnp-3682 85 15 philippe philippe PROPN fnp-3682 85 16 codron1,2,3 codron1,2,3 PROPN fnp-3682 85 17 , , PUNCT fnp-3682 85 18 franck franck X fnp-3682 86 1 letournel1,2 letournel1,2 PROPN fnp-3682 86 2 , , PUNCT fnp-3682 86 3 guy guy NOUN fnp-3682 86 4 lenaers1,3 lenaers1,3 PROPN fnp-3682 86 5 , , PUNCT fnp-3682 86 6 arnaud arnaud NOUN fnp-3682 86 7 chevrollier3 chevrollier3 VERB fnp-3682 86 8 1 1 NUM fnp-3682 86 9 service service NOUN fnp-3682 86 10 de de X fnp-3682 86 11 neurologie neurologie X fnp-3682 86 12 , , PUNCT fnp-3682 86 13 centre centre NOUN fnp-3682 86 14 hospitalier hospitalier ADJ fnp-3682 86 15 universitaire universitaire NOUN fnp-3682 86 16 d’angers d’anger NOUN fnp-3682 86 17 , , PUNCT fnp-3682 86 18 angers anger NOUN fnp-3682 86 19 , , PUNCT fnp-3682 86 20 france france PROPN fnp-3682 86 21 2 2 NUM fnp-3682 86 22 service service NOUN fnp-3682 86 23 de de X fnp-3682 86 24 neurobiologie neurobiologie PROPN fnp-3682 86 25 et et PROPN fnp-3682 86 26 neuropathologie neuropathologie NOUN fnp-3682 86 27 , , PUNCT fnp-3682 86 28 centre centre NOUN fnp-3682 86 29 hospitalier hospitalier ADJ fnp-3682 86 30 universitaire universitaire NOUN fnp-3682 86 31 d’angers d’anger NOUN fnp-3682 86 32 , , PUNCT fnp-3682 86 33 angers anger VERB fnp-3682 86 34 , , PUNCT fnp-3682 86 35 france france PROPN fnp-3682 86 36 3 3 NUM fnp-3682 86 37 équipe équipe PROPN fnp-3682 86 38 mitolab mitolab PROPN fnp-3682 86 39 , , PUNCT fnp-3682 86 40 institut institut PROPN fnp-3682 86 41 mitovasc mitovasc PROPN fnp-3682 86 42 , , PUNCT fnp-3682 86 43 inserm inserm NOUN fnp-3682 86 44 u1083 u1083 PROPN fnp-3682 86 45 , , PUNCT fnp-3682 86 46 cnrs cnrs NOUN fnp-3682 86 47 6015 6015 NUM fnp-3682 86 48 , , PUNCT fnp-3682 86 49 université université PROPN fnp-3682 86 50 d'angers d'anger NOUN fnp-3682 86 51 , , PUNCT fnp-3682 86 52 angers anger VERB fnp-3682 86 53 , , PUNCT fnp-3682 86 54 france france PROPN fnp-3682 86 55 the the DET fnp-3682 86 56 recent recent ADJ fnp-3682 86 57 development development NOUN fnp-3682 86 58 of of ADP fnp-3682 86 59 stochastic stochastic ADJ fnp-3682 86 60 optical optical ADJ fnp-3682 86 61 reconstruction reconstruction NOUN fnp-3682 86 62 microscopy microscopy NOUN fnp-3682 86 63 ( ( PUNCT fnp-3682 86 64 storm storm NOUN fnp-3682 86 65 ) ) PUNCT fnp-3682 86 66 has have AUX fnp-3682 86 67 contributed contribute VERB fnp-3682 86 68 to to ADP fnp-3682 86 69 major major ADJ fnp-3682 86 70 advances advance NOUN fnp-3682 86 71 in in ADP fnp-3682 86 72 neuroscience neuroscience NOUN fnp-3682 86 73 . . PUNCT fnp-3682 87 1 however however ADV fnp-3682 87 2 this this DET fnp-3682 87 3 technique technique NOUN fnp-3682 87 4 is be AUX fnp-3682 87 5 restricted restrict VERB fnp-3682 87 6 to to ADP fnp-3682 87 7 cultured cultured ADJ fnp-3682 87 8 cells cell NOUN fnp-3682 87 9 and and CCONJ fnp-3682 87 10 rodent rodent ADJ fnp-3682 87 11 brain brain NOUN fnp-3682 87 12 , , PUNCT fnp-3682 87 13 and and CCONJ fnp-3682 87 14 no no DET fnp-3682 87 15 experiment experiment NOUN fnp-3682 87 16 on on ADP fnp-3682 87 17 human human ADJ fnp-3682 87 18 samples sample NOUN fnp-3682 87 19 has have AUX fnp-3682 87 20 been be AUX fnp-3682 87 21 reported report VERB fnp-3682 87 22 so so ADV fnp-3682 87 23 far far ADV fnp-3682 87 24 . . PUNCT fnp-3682 88 1 to to ADP fnp-3682 88 2 this this DET fnp-3682 88 3 end end NOUN fnp-3682 88 4 , , PUNCT fnp-3682 88 5 we we PRON fnp-3682 88 6 combined combine VERB fnp-3682 88 7 cellular cellular ADJ fnp-3682 88 8 microscopy microscopy NOUN fnp-3682 88 9 protocols protocol NOUN fnp-3682 88 10 with with ADP fnp-3682 88 11 neuropathology neuropathology NOUN fnp-3682 88 12 tissue tissue NOUN fnp-3682 88 13 preparation preparation NOUN fnp-3682 88 14 techniques technique NOUN fnp-3682 88 15 to to PART fnp-3682 88 16 characterize characterize VERB fnp-3682 88 17 physiological physiological ADJ fnp-3682 88 18 and and CCONJ fnp-3682 88 19 pathological pathological ADJ fnp-3682 88 20 structures structure NOUN fnp-3682 88 21 in in ADP fnp-3682 88 22 brain brain NOUN fnp-3682 88 23 samples sample NOUN fnp-3682 88 24 with with ADP fnp-3682 88 25 2d- 2d- NUM fnp-3682 88 26 , , PUNCT fnp-3682 88 27 3dand 3dand NUM fnp-3682 88 28 two two NUM fnp-3682 88 29 - - PUNCT fnp-3682 88 30 color color NOUN fnp-3682 88 31 storm storm NOUN fnp-3682 88 32 . . PUNCT fnp-3682 89 1 this this DET fnp-3682 89 2 approach approach NOUN fnp-3682 89 3 proved prove VERB fnp-3682 89 4 to to PART fnp-3682 89 5 be be AUX fnp-3682 89 6 particularly particularly ADV fnp-3682 89 7 effective effective ADJ fnp-3682 89 8 at at ADP fnp-3682 89 9 visualizing visualize VERB fnp-3682 89 10 the the DET fnp-3682 89 11 organization organization NOUN fnp-3682 89 12 of of ADP fnp-3682 89 13 dense dense ADJ fnp-3682 89 14 protein protein NOUN fnp-3682 89 15 inclusions inclusion NOUN fnp-3682 89 16 in in ADP fnp-3682 89 17 samples sample NOUN fnp-3682 89 18 from from ADP fnp-3682 89 19 patients patient NOUN fnp-3682 89 20 affected affect VERB fnp-3682 89 21 with with ADP fnp-3682 89 22 neurodegenerative neurodegenerative ADJ fnp-3682 89 23 diseases disease NOUN fnp-3682 89 24 . . PUNCT fnp-3682 90 1 these these DET fnp-3682 90 2 very very ADV fnp-3682 90 3 first first ADJ fnp-3682 90 4 results result NOUN fnp-3682 90 5 open open VERB fnp-3682 90 6 further further ADJ fnp-3682 90 7 gates gate NOUN fnp-3682 90 8 to to ADP fnp-3682 90 9 a a DET fnp-3682 90 10 more more ADV fnp-3682 90 11 comprehensive comprehensive ADJ fnp-3682 90 12 understanding understanding NOUN fnp-3682 90 13 of of ADP fnp-3682 90 14 the the DET fnp-3682 90 15 human human ADJ fnp-3682 90 16 brain brain NOUN fnp-3682 90 17 organization organization NOUN fnp-3682 90 18 and and CCONJ fnp-3682 90 19 revelations revelation NOUN fnp-3682 90 20 about about ADP fnp-3682 90 21 the the DET fnp-3682 90 22 underlying underlie VERB fnp-3682 90 23 mechanisms mechanism NOUN fnp-3682 90 24 responsible responsible ADJ fnp-3682 90 25 for for ADP fnp-3682 90 26 neurodegenerative neurodegenerative ADJ fnp-3682 90 27 disorders disorder NOUN fnp-3682 90 28 . . PUNCT fnp-3682 90 29         SPACE fnp-3682 91 1 free free ADJ fnp-3682 91 2 neuropathol neuropathol NOUN fnp-3682 91 3 2:32:16 2:32:16 NUM fnp-3682 91 4 ai ai AUX fnp-3682 91 5 applied apply VERB fnp-3682 91 6 in in ADP fnp-3682 91 7 neuropathology neuropathology NOUN fnp-3682 91 8 : : PUNCT fnp-3682 91 9 automated automate VERB fnp-3682 91 10 detection detection NOUN fnp-3682 91 11 of of ADP fnp-3682 91 12 intraepidermal intraepidermal ADJ fnp-3682 91 13 nerve nerve NOUN fnp-3682 91 14 fibers fiber NOUN fnp-3682 91 15 for for ADP fnp-3682 91 16 the the DET fnp-3682 91 17 diagnosis diagnosis NOUN fnp-3682 91 18 of of ADP fnp-3682 91 19 small small ADJ fnp-3682 91 20 - - PUNCT fnp-3682 91 21 fiber fiber NOUN fnp-3682 91 22 neuropathies neuropathy NOUN fnp-3682 91 23 labeyrie labeyrie VERB fnp-3682 91 24 c1,2,3 c1,2,3 PROPN fnp-3682 91 25 , , PUNCT fnp-3682 91 26 adam adam PROPN fnp-3682 91 27 c.2,3 c.2,3 PROPN fnp-3682 91 28 , , PUNCT fnp-3682 91 29 lorenzo lorenzo VERB fnp-3682 91 30 a.4 a.4 PROPN fnp-3682 91 31 , , PUNCT fnp-3682 91 32 brunel brunel PROPN fnp-3682 91 33 n.4 n.4 PROPN fnp-3682 91 34 , , PUNCT fnp-3682 91 35 blot blot NOUN fnp-3682 91 36 v.4 v.4 NOUN fnp-3682 91 37 , , PUNCT fnp-3682 91 38 sevillia sevillia NOUN fnp-3682 91 39 h.4 h.4 NOUN fnp-3682 91 40 , , PUNCT fnp-3682 91 41 hervault hervault NOUN fnp-3682 91 42 d.4 d.4 NOUN fnp-3682 91 43 , , PUNCT fnp-3682 91 44 trassard trassard ADV fnp-3682 91 45 o.3 o.3 VERB fnp-3682 91 46 , , PUNCT fnp-3682 91 47 morassi morassi ADJ fnp-3682 91 48 o.1 o.1 X fnp-3682 91 49 , , PUNCT fnp-3682 91 50 adams adams PROPN fnp-3682 91 51 d.1,4 d.1,4 PROPN fnp-3682 91 52 , , PUNCT fnp-3682 91 53 guettier guettier NOUN fnp-3682 91 54 c2,3 c2,3 NOUN fnp-3682 91 55 1 1 NUM fnp-3682 91 56 service service NOUN fnp-3682 91 57 de de X fnp-3682 91 58 neurologie neurologie X fnp-3682 91 59 adulte adulte PROPN fnp-3682 91 60 , , PUNCT fnp-3682 91 61 crmr crmr PROPN fnp-3682 91 62 neuropathie neuropathie PROPN fnp-3682 91 63 amyloïde amyloïde PROPN fnp-3682 91 64 familiale familiale PROPN fnp-3682 91 65 et et PROPN fnp-3682 91 66 autres autres PROPN fnp-3682 91 67 neuropathies neuropathies PROPN fnp-3682 91 68 périphériques périphériques PROPN fnp-3682 91 69 rares rare NOUN fnp-3682 91 70 ( ( PUNCT fnp-3682 91 71 nnerf nnerf NOUN fnp-3682 91 72 ) ) PUNCT fnp-3682 91 73 , , PUNCT fnp-3682 91 74 chu chu PROPN fnp-3682 91 75 bicêtre bicêtre PROPN fnp-3682 91 76 , , PUNCT fnp-3682 91 77 78 78 NUM fnp-3682 91 78 rue rue X fnp-3682 91 79 du du PROPN fnp-3682 91 80 gal gal PROPN fnp-3682 91 81 leclerc leclerc PROPN fnp-3682 91 82 , , PUNCT fnp-3682 91 83 94275 94275 NUM fnp-3682 91 84 le le ADP fnp-3682 91 85 kremlin kremlin PROPN fnp-3682 91 86 - - PUNCT fnp-3682 91 87 bicêre bicêre PROPN fnp-3682 91 88 , , PUNCT fnp-3682 91 89 aphp aphp PROPN fnp-3682 91 90 , , PUNCT fnp-3682 91 91 france france PROPN fnp-3682 91 92 2 2 NUM fnp-3682 91 93 service service NOUN fnp-3682 91 94 d’anatomopathologie d’anatomopathologie PROPN fnp-3682 91 95 , , PUNCT fnp-3682 91 96 chu chu PROPN fnp-3682 91 97 bicêtre bicêtre NOUN fnp-3682 91 98 , , PUNCT fnp-3682 91 99 78 78 NUM fnp-3682 91 100 rue rue X fnp-3682 91 101 du du PROPN fnp-3682 91 102 gal gal PROPN fnp-3682 91 103 leclerc leclerc PROPN fnp-3682 91 104 , , PUNCT fnp-3682 91 105 94275 94275 NUM fnp-3682 91 106 le le ADP fnp-3682 91 107 kremlin kremlin PROPN fnp-3682 91 108 - - PUNCT fnp-3682 91 109 bicêre bicêre PROPN fnp-3682 91 110 , , PUNCT fnp-3682 91 111 aphp aphp PROPN fnp-3682 91 112 , , PUNCT fnp-3682 91 113 france france PROPN fnp-3682 91 114 3 3 NUM fnp-3682 91 115 institut institut PROPN fnp-3682 91 116 biomédical biomédical PROPN fnp-3682 91 117 de de PROPN fnp-3682 91 118 bicêtre bicêtre NOUN fnp-3682 91 119 , , PUNCT fnp-3682 91 120 ums32 ums32 PROPN fnp-3682 91 121 , , PUNCT fnp-3682 91 122 chu chu NOUN fnp-3682 91 123 bicêtre bicêtre NOUN fnp-3682 91 124 , , PUNCT fnp-3682 91 125 78 78 NUM fnp-3682 91 126 rue rue X fnp-3682 91 127 du du PROPN fnp-3682 91 128 gal gal PROPN fnp-3682 91 129 leclerc leclerc PROPN fnp-3682 91 130 , , PUNCT fnp-3682 91 131 94275 94275 NUM fnp-3682 91 132 le le ADP fnp-3682 91 133 kremlin kremlin PROPN fnp-3682 91 134 - - PUNCT fnp-3682 91 135 bicêre bicêre PROPN fnp-3682 91 136 , , PUNCT fnp-3682 91 137 aphp aphp PROPN fnp-3682 91 138 , , PUNCT fnp-3682 91 139 france france PROPN fnp-3682 91 140 4 4 NUM fnp-3682 91 141 quantmetry quantmetry NOUN fnp-3682 91 142 , , PUNCT fnp-3682 91 143 52 52 NUM fnp-3682 91 144 rue rue X fnp-3682 91 145 d’anjou d’anjou NOUN fnp-3682 91 146 , , PUNCT fnp-3682 91 147 75008 75008 NUM fnp-3682 91 148 paris paris PROPN fnp-3682 91 149 , , PUNCT fnp-3682 91 150 france france PROPN fnp-3682 91 151 5 5 NUM fnp-3682 91 152 umr1195 umr1195 ADV fnp-3682 91 153 , , PUNCT fnp-3682 91 154 université université PROPN fnp-3682 91 155 paris paris PROPN fnp-3682 91 156 sud sud PROPN fnp-3682 91 157 , , PUNCT fnp-3682 91 158 faculté faculté PROPN fnp-3682 91 159 de de X fnp-3682 91 160 médecine médecine PROPN fnp-3682 91 161 bicêtre bicêtre NOUN fnp-3682 91 162 , , PUNCT fnp-3682 91 163 80 80 NUM fnp-3682 91 164 rue rue X fnp-3682 91 165 du du PROPN fnp-3682 91 166 gal gal PROPN fnp-3682 91 167 leclerc leclerc PROPN fnp-3682 91 168 , , PUNCT fnp-3682 91 169 94276 94276 NUM fnp-3682 91 170 le le ADP fnp-3682 91 171 kremlin kremlin PROPN fnp-3682 91 172 - - PUNCT fnp-3682 91 173 bicêre bicêre PROPN fnp-3682 91 174 , , PUNCT fnp-3682 91 175 aphp aphp PROPN fnp-3682 91 176 , , PUNCT fnp-3682 91 177 france france PROPN fnp-3682 91 178 the the DET fnp-3682 91 179 measurement measurement NOUN fnp-3682 91 180 of of ADP fnp-3682 91 181 intra intra ADJ fnp-3682 91 182 - - ADJ fnp-3682 91 183 epidermal epidermal ADJ fnp-3682 91 184 nerve nerve NOUN fnp-3682 91 185 fiber fiber NOUN fnp-3682 91 186 density density NOUN fnp-3682 91 187 ( ( PUNCT fnp-3682 91 188 ienfd ienfd PROPN fnp-3682 91 189 ) ) PUNCT fnp-3682 91 190 in in ADP fnp-3682 91 191 skin skin NOUN fnp-3682 91 192 biopsy biopsy NOUN fnp-3682 91 193 is be AUX fnp-3682 91 194 the the DET fnp-3682 91 195 gold gold ADJ fnp-3682 91 196 standard standard NOUN fnp-3682 91 197 for for ADP fnp-3682 91 198 the the DET fnp-3682 91 199 diagnosis diagnosis NOUN fnp-3682 91 200 of of ADP fnp-3682 91 201 small small ADJ fnp-3682 91 202 fiber fiber NOUN fnp-3682 91 203 neuropathy neuropathy ADJ fnp-3682 91 204 ( ( PUNCT fnp-3682 91 205 sfn sfn PROPN fnp-3682 91 206 ) ) PUNCT fnp-3682 91 207 . . PUNCT fnp-3682 92 1 this this PRON fnp-3682 92 2 recently recently ADV fnp-3682 92 3 described describe VERB fnp-3682 92 4 entity entity NOUN fnp-3682 92 5 causes cause VERB fnp-3682 92 6 neuropathic neuropathic ADJ fnp-3682 92 7 pain pain NOUN fnp-3682 92 8 and and CCONJ fnp-3682 92 9 dysautonomia dysautonomia NOUN fnp-3682 92 10 . . PUNCT fnp-3682 93 1 numerous numerous ADJ fnp-3682 93 2 etiologies etiology NOUN fnp-3682 93 3 are be AUX fnp-3682 93 4 described describe VERB fnp-3682 93 5 , , PUNCT fnp-3682 93 6 although although SCONJ fnp-3682 93 7 the the DET fnp-3682 93 8 majority majority NOUN fnp-3682 93 9 of of ADP fnp-3682 93 10 them they PRON fnp-3682 93 11 remain remain VERB fnp-3682 93 12 idiopathic idiopathic ADJ fnp-3682 93 13 . . PUNCT fnp-3682 94 1 the the DET fnp-3682 94 2 classic classic ADJ fnp-3682 94 3 dfnie dfnie PROPN fnp-3682 94 4 reading reading NOUN fnp-3682 94 5 method method NOUN fnp-3682 94 6 , , PUNCT fnp-3682 94 7 derived derive VERB fnp-3682 94 8 from from ADP fnp-3682 94 9 a a DET fnp-3682 94 10 3 3 NUM fnp-3682 94 11 mm mm NOUN fnp-3682 94 12 punch punch NOUN fnp-3682 94 13 biopsy biopsy NOUN fnp-3682 94 14 and and CCONJ fnp-3682 94 15 50 50 NUM fnp-3682 94 16 micron micron NOUN fnp-3682 94 17 sections section NOUN fnp-3682 94 18 , , PUNCT fnp-3682 94 19 is be AUX fnp-3682 94 20 based base VERB fnp-3682 94 21 on on ADP fnp-3682 94 22 the the DET fnp-3682 94 23 anti anti ADJ fnp-3682 94 24 - - ADJ fnp-3682 94 25 pgp9.5 pgp9.5 NOUN fnp-3682 94 26 labelling labelling NOUN fnp-3682 94 27 with with ADP fnp-3682 94 28 a a DET fnp-3682 94 29 visual visual ADJ fnp-3682 94 30 count count NOUN fnp-3682 94 31 related relate VERB fnp-3682 94 32 to to ADP fnp-3682 94 33 the the DET fnp-3682 94 34 analyzed analyze VERB fnp-3682 94 35 length length NOUN fnp-3682 94 36 , , PUNCT fnp-3682 94 37 a a DET fnp-3682 94 38 long long ADJ fnp-3682 94 39 process process NOUN fnp-3682 94 40 thus thus ADV fnp-3682 94 41 slowing slow VERB fnp-3682 94 42 down down ADP fnp-3682 94 43 its its PRON fnp-3682 94 44 development development NOUN fnp-3682 94 45 . . PUNCT fnp-3682 95 1 thanks thank NOUN fnp-3682 95 2 to to ADP fnp-3682 95 3 the the DET fnp-3682 95 4 digitization digitization NOUN fnp-3682 95 5 of of ADP fnp-3682 95 6 the the DET fnp-3682 95 7 double double ADJ fnp-3682 95 8 - - PUNCT fnp-3682 95 9 labeled label VERB fnp-3682 95 10 slides slide NOUN fnp-3682 95 11 in in ADP fnp-3682 95 12 immunofluorescence immunofluorescence NOUN fnp-3682 95 13 anti anti NOUN fnp-3682 95 14 - - NOUN fnp-3682 95 15 pgp9.5 pgp9.5 NOUN fnp-3682 95 16 and and CCONJ fnp-3682 95 17 anti anti ADJ fnp-3682 95 18 - - ADJ fnp-3682 95 19 coll coll ADJ fnp-3682 95 20 iv iv NUM fnp-3682 95 21 since since SCONJ fnp-3682 95 22 2012 2012 NUM fnp-3682 95 23 allowing allow VERB fnp-3682 95 24 the the DET fnp-3682 95 25 computer computer NOUN fnp-3682 95 26 labeling labeling NOUN fnp-3682 95 27 of of ADP fnp-3682 95 28 the the DET fnp-3682 95 29 traversing traverse VERB fnp-3682 95 30 fibers fiber NOUN fnp-3682 95 31 , , PUNCT fnp-3682 95 32 we we PRON fnp-3682 95 33 were be AUX fnp-3682 95 34 able able ADJ fnp-3682 95 35 to to PART fnp-3682 95 36 train train VERB fnp-3682 95 37 an an DET fnp-3682 95 38 automated automate VERB fnp-3682 95 39 reading reading NOUN fnp-3682 95 40 algorithm algorithm NOUN fnp-3682 95 41 which which PRON fnp-3682 95 42 obtains obtain VERB fnp-3682 95 43 an an DET fnp-3682 95 44 accuracy accuracy NOUN fnp-3682 95 45 of of ADP fnp-3682 95 46 71 71 NUM fnp-3682 95 47 % % NOUN fnp-3682 95 48 and and CCONJ fnp-3682 95 49 a a DET fnp-3682 95 50 recall recall NOUN fnp-3682 95 51 of of ADP fnp-3682 95 52 77 77 NUM fnp-3682 95 53 % % NOUN fnp-3682 95 54 . . PUNCT fnp-3682 95 55         SPACE fnp-3682 96 1 free free ADJ fnp-3682 96 2 neuropathol neuropathol NOUN fnp-3682 96 3 2:32:17 2:32:17 NUM fnp-3682 96 4 histological histological ADJ fnp-3682 96 5 description description NOUN fnp-3682 96 6 of of ADP fnp-3682 96 7 myopathy myopathy ADJ fnp-3682 96 8 related relate VERB fnp-3682 96 9 to to ADP fnp-3682 96 10 chronic chronic ADJ fnp-3682 96 11 graft graft NOUN fnp-3682 96 12 versus versus ADP fnp-3682 96 13 host host NOUN fnp-3682 96 14 disease disease NOUN fnp-3682 96 15 and and CCONJ fnp-3682 96 16 characterization characterization NOUN fnp-3682 96 17 of of ADP fnp-3682 96 18 inflammatory inflammatory ADJ fnp-3682 96 19 infiltrate infiltrate NOUN fnp-3682 96 20 by by ADP fnp-3682 96 21 imaging image VERB fnp-3682 96 22 mass mass PROPN fnp-3682 96 23 cytometry cytometry PROPN fnp-3682 96 24 amélie amélie PROPN fnp-3682 96 25 bourhis1,2 bourhis1,2 PROPN fnp-3682 96 26 , , PUNCT fnp-3682 96 27 baptiste baptiste PROPN fnp-3682 96 28 hervier3,4 hervier3,4 PROPN fnp-3682 96 29 , , PUNCT fnp-3682 96 30 arnaud arnaud PROPN fnp-3682 96 31 uguen1,2 uguen1,2 PROPN fnp-3682 96 32 , , PUNCT fnp-3682 96 33 pascale pascale PROPN fnp-3682 96 34 marcorelles1 marcorelles1 PROPN fnp-3682 96 35 , , PUNCT fnp-3682 96 36 patrice patrice NOUN fnp-3682 96 37 hemon2 hemon2 PROPN fnp-3682 96 38 , , PUNCT fnp-3682 96 39 sarah sarah PROPN fnp-3682 96 40 léonard léonard PROPN fnp-3682 96 41 - - PUNCT fnp-3682 96 42 louis5,6 louis5,6 PROPN fnp-3682 96 43 1 1 NUM fnp-3682 96 44 pathology pathology NOUN fnp-3682 96 45 department department NOUN fnp-3682 96 46 , , PUNCT fnp-3682 96 47 hospital hospital NOUN fnp-3682 96 48 morvan morvan PROPN fnp-3682 96 49 , , PUNCT fnp-3682 96 50 brest brest NOUN fnp-3682 96 51 , , PUNCT fnp-3682 96 52 france france PROPN fnp-3682 96 53 2 2 NUM fnp-3682 96 54 lbai lbai NOUN fnp-3682 96 55 , , PUNCT fnp-3682 96 56 umr1227 umr1227 PROPN fnp-3682 96 57 , , PUNCT fnp-3682 96 58 univ univ ADJ fnp-3682 96 59 brest brest NOUN fnp-3682 96 60 , , PUNCT fnp-3682 96 61 inserm inserm NOUN fnp-3682 96 62 , , PUNCT fnp-3682 96 63 labex labex PROPN fnp-3682 96 64 igo igo PROPN fnp-3682 96 65 , , PUNCT fnp-3682 96 66 brest brest NOUN fnp-3682 96 67 , , PUNCT fnp-3682 96 68 france france PROPN fnp-3682 96 69 3 3 NUM fnp-3682 96 70 internal internal ADJ fnp-3682 96 71 medicine medicine NOUN fnp-3682 96 72 and and CCONJ fnp-3682 96 73 clinical clinical ADJ fnp-3682 96 74 immunology immunology NOUN fnp-3682 96 75 department department NOUN fnp-3682 96 76 , , PUNCT fnp-3682 96 77 french french ADJ fnp-3682 96 78 referral referral ADJ fnp-3682 96 79 centre centre NOUN fnp-3682 96 80 for for ADP fnp-3682 96 81 rare rare ADJ fnp-3682 96 82 neuromuscular neuromuscular ADJ fnp-3682 96 83 disorders disorder NOUN fnp-3682 96 84 , , PUNCT fnp-3682 96 85 hôpital hôpital ADJ fnp-3682 96 86 pitié pitié PROPN fnp-3682 96 87 - - PUNCT fnp-3682 96 88 salpêtrière salpêtrière PROPN fnp-3682 96 89 , , PUNCT fnp-3682 96 90 aphp aphp ADJ fnp-3682 96 91 , , PUNCT fnp-3682 96 92 paris paris PROPN fnp-3682 96 93 , , PUNCT fnp-3682 96 94 france france PROPN fnp-3682 96 95 4 4 NUM fnp-3682 96 96 inserm inserm VERB fnp-3682 96 97 umr umr PROPN fnp-3682 96 98 - - PUNCT fnp-3682 96 99 s s PART fnp-3682 96 100 1135 1135 NUM fnp-3682 96 101 , , PUNCT fnp-3682 96 102 cimi cimi NOUN fnp-3682 96 103 - - PUNCT fnp-3682 96 104 paris paris PROPN fnp-3682 96 105 , , PUNCT fnp-3682 96 106 upmc upmc PROPN fnp-3682 96 107 & & CCONJ fnp-3682 96 108 sorbonne sorbonne PROPN fnp-3682 96 109 université université PROPN fnp-3682 96 110 , , PUNCT fnp-3682 96 111 paris paris PROPN fnp-3682 96 112 , , PUNCT fnp-3682 96 113 france france PROPN fnp-3682 96 114 5 5 NUM fnp-3682 96 115 neuropathology neuropathology NOUN fnp-3682 96 116 department department NOUN fnp-3682 96 117 , , PUNCT fnp-3682 96 118 aphp aphp PROPN fnp-3682 96 119 , , PUNCT fnp-3682 96 120 pitié pitié PROPN fnp-3682 96 121 salpétrière salpétrière PROPN fnp-3682 96 122 , , PUNCT fnp-3682 96 123 sorbonne sorbonne PROPN fnp-3682 96 124 university university PROPN fnp-3682 96 125 , , PUNCT fnp-3682 96 126 paris paris PROPN fnp-3682 96 127 , , PUNCT fnp-3682 96 128 france france PROPN fnp-3682 96 129 6 6 NUM fnp-3682 96 130 institute institute NOUN fnp-3682 96 131 of of ADP fnp-3682 96 132 myology myology NOUN fnp-3682 96 133 , , PUNCT fnp-3682 96 134 neuromuscular neuromuscular ADJ fnp-3682 96 135 reference reference NOUN fnp-3682 96 136 center center NOUN fnp-3682 96 137 nord nord PROPN fnp-3682 96 138 / / SYM fnp-3682 96 139 est est PROPN fnp-3682 96 140 / / SYM fnp-3682 96 141 ile ile PROPN fnp-3682 96 142 de de PROPN fnp-3682 96 143 france france PROPN fnp-3682 96 144 , , PUNCT fnp-3682 96 145 ap ap PROPN fnp-3682 96 146 - - PUNCT fnp-3682 96 147 hp hp PROPN fnp-3682 96 148 , , PUNCT fnp-3682 96 149 pitié pitié NOUN fnp-3682 96 150 - - PUNCT fnp-3682 96 151 salpêtrière salpêtrière NOUN fnp-3682 96 152 hospital hospital NOUN fnp-3682 96 153 , , PUNCT fnp-3682 96 154 sorbonne sorbonne PROPN fnp-3682 96 155 university university PROPN fnp-3682 96 156 , , PUNCT fnp-3682 96 157 paris paris PROPN fnp-3682 96 158 , , PUNCT fnp-3682 96 159 france france PROPN fnp-3682 96 160 chronic chronic ADJ fnp-3682 96 161 graft graft NOUN fnp-3682 96 162 versus versus ADP fnp-3682 96 163 host host NOUN fnp-3682 96 164 disease disease NOUN fnp-3682 96 165 ( ( PUNCT fnp-3682 96 166 cgvhd cgvhd NOUN fnp-3682 96 167 ) ) PUNCT fnp-3682 96 168 is be AUX fnp-3682 96 169 a a DET fnp-3682 96 170 long long ADJ fnp-3682 96 171 - - PUNCT fnp-3682 96 172 term term NOUN fnp-3682 96 173 side side NOUN fnp-3682 96 174 effect effect NOUN fnp-3682 96 175 of of ADP fnp-3682 96 176 allogenic allogenic ADJ fnp-3682 96 177 hematopoietic hematopoietic ADJ fnp-3682 96 178 cells cell NOUN fnp-3682 96 179 transplantation transplantation NOUN fnp-3682 96 180 , , PUNCT fnp-3682 96 181 affecting affect VERB fnp-3682 96 182 muscles muscle NOUN fnp-3682 96 183 in in ADP fnp-3682 96 184 3,4 3,4 NUM fnp-3682 96 185 to to ADP fnp-3682 96 186 7,7 7,7 NUM fnp-3682 96 187 % % NOUN fnp-3682 96 188 of of ADP fnp-3682 96 189 patients patient NOUN fnp-3682 96 190 . . PUNCT fnp-3682 97 1 this this DET fnp-3682 97 2 study study NOUN fnp-3682 97 3 proposes propose VERB fnp-3682 97 4 a a DET fnp-3682 97 5 complete complete ADJ fnp-3682 97 6 histological histological ADJ fnp-3682 97 7 and and CCONJ fnp-3682 97 8 immunohistological immunohistological ADJ fnp-3682 97 9 description description NOUN fnp-3682 97 10 of of ADP fnp-3682 97 11 myopathy myopathy ADJ fnp-3682 97 12 in in ADP fnp-3682 97 13 the the DET fnp-3682 97 14 context context NOUN fnp-3682 97 15 of of ADP fnp-3682 97 16 cgvhd cgvhd NOUN fnp-3682 97 17 and and CCONJ fnp-3682 97 18 a a DET fnp-3682 97 19 characterization characterization NOUN fnp-3682 97 20 of of ADP fnp-3682 97 21 the the DET fnp-3682 97 22 inflammatory inflammatory ADJ fnp-3682 97 23 infiltrate infiltrate NOUN fnp-3682 97 24 by by ADP fnp-3682 97 25 imaging image VERB fnp-3682 97 26 mass mass PROPN fnp-3682 97 27 cytometry cytometry PROPN fnp-3682 97 28 technology technology NOUN fnp-3682 97 29 ( ( PUNCT fnp-3682 97 30 imc imc PROPN fnp-3682 97 31 ) ) PUNCT fnp-3682 97 32 . . PUNCT fnp-3682 98 1 histological histological ADJ fnp-3682 98 2 description description NOUN fnp-3682 98 3 was be AUX fnp-3682 98 4 performed perform VERB fnp-3682 98 5 on on ADP fnp-3682 98 6 19 19 NUM fnp-3682 98 7 patients patient NOUN fnp-3682 98 8 and and CCONJ fnp-3682 98 9 divided divide VERB fnp-3682 98 10 patients patient NOUN fnp-3682 98 11 into into ADP fnp-3682 98 12 three three NUM fnp-3682 98 13 groups group NOUN fnp-3682 98 14 : : PUNCT fnp-3682 98 15 10 10 NUM fnp-3682 98 16 patients patient NOUN fnp-3682 98 17 with with ADP fnp-3682 98 18 no no DET fnp-3682 98 19 fiber fiber NOUN fnp-3682 98 20 necrosis necrosis NOUN fnp-3682 98 21 and and CCONJ fnp-3682 98 22 no no DET fnp-3682 98 23 or or CCONJ fnp-3682 98 24 very very ADV fnp-3682 98 25 low low ADJ fnp-3682 98 26 inflammatory inflammatory ADJ fnp-3682 98 27 infiltrate infiltrate NOUN fnp-3682 98 28 , , PUNCT fnp-3682 98 29 6 6 NUM fnp-3682 98 30 patients patient NOUN fnp-3682 98 31 with with ADP fnp-3682 98 32 fiber fiber NOUN fnp-3682 98 33 necrosis necrosis NOUN fnp-3682 98 34 and and CCONJ fnp-3682 98 35 high high ADJ fnp-3682 98 36 inflammatory inflammatory ADJ fnp-3682 98 37 infiltrate infiltrate NOUN fnp-3682 98 38 and and CCONJ fnp-3682 98 39 3 3 NUM fnp-3682 98 40 patients patient NOUN fnp-3682 98 41 with with ADP fnp-3682 98 42 fasciitis fasciitis NOUN fnp-3682 98 43 . . PUNCT fnp-3682 99 1 all all DET fnp-3682 99 2 patients patient NOUN fnp-3682 99 3 had have VERB fnp-3682 99 4 variations variation NOUN fnp-3682 99 5 in in ADP fnp-3682 99 6 fiber fiber NOUN fnp-3682 99 7 size size NOUN fnp-3682 99 8 , , PUNCT fnp-3682 99 9 diffuse diffuse PROPN fnp-3682 99 10 mch mch PROPN fnp-3682 99 11 - - PUNCT fnp-3682 99 12 i i PROPN fnp-3682 99 13 and and CCONJ fnp-3682 99 14 perifascicular perifascicular ADJ fnp-3682 99 15 mch mch PROPN fnp-3682 99 16 - - PUNCT fnp-3682 99 17 ii ii PROPN fnp-3682 99 18 immunostaining immunostaining NOUN fnp-3682 99 19 . . PUNCT fnp-3682 100 1 7 7 NUM fnp-3682 100 2 patients patient NOUN fnp-3682 100 3 were be AUX fnp-3682 100 4 analyzed analyze VERB fnp-3682 100 5 by by ADP fnp-3682 100 6 imc imc PROPN fnp-3682 100 7 . . PUNCT fnp-3682 101 1 the the DET fnp-3682 101 2 main main ADJ fnp-3682 101 3 inflammatory inflammatory ADJ fnp-3682 101 4 population population NOUN fnp-3682 101 5 was be AUX fnp-3682 101 6 macrophage macrophage ADJ fnp-3682 101 7 cells cell NOUN fnp-3682 101 8 , , PUNCT fnp-3682 101 9 but but CCONJ fnp-3682 101 10 eosinophils eosinophil NOUN fnp-3682 101 11 represented represent VERB fnp-3682 101 12 more more ADJ fnp-3682 101 13 than than ADP fnp-3682 101 14 5 5 NUM fnp-3682 101 15 % % NOUN fnp-3682 101 16 of of ADP fnp-3682 101 17 inflammatory inflammatory ADJ fnp-3682 101 18 cells cell NOUN fnp-3682 101 19 in in ADP fnp-3682 101 20 5 5 NUM fnp-3682 101 21 cases case NOUN fnp-3682 101 22 and and CCONJ fnp-3682 101 23 seemed seem VERB fnp-3682 101 24 to to PART fnp-3682 101 25 be be AUX fnp-3682 101 26 specific specific ADJ fnp-3682 101 27 of of ADP fnp-3682 101 28 cgvhd cgvhd NOUN fnp-3682 101 29 induced induce VERB fnp-3682 101 30 myopathy myopathy ADJ fnp-3682 101 31 as as SCONJ fnp-3682 101 32 they they PRON fnp-3682 101 33 were be AUX fnp-3682 101 34 already already ADV fnp-3682 101 35 described describe VERB fnp-3682 101 36 in in ADP fnp-3682 101 37 other other ADJ fnp-3682 101 38 cgvhd cgvhd NOUN fnp-3682 101 39 locations location NOUN fnp-3682 101 40 . . PUNCT fnp-3682 101 41         SPACE fnp-3682 102 1 free free ADJ fnp-3682 102 2 neuropathol neuropathol NOUN fnp-3682 102 3 2:32:18 2:32:18 PROPN fnp-3682 102 4 highlighting highlight VERB fnp-3682 102 5 autophagy autophagy ADV fnp-3682 102 6 in in ADP fnp-3682 102 7 a a DET fnp-3682 102 8 fatal fatal ADJ fnp-3682 102 9 case case NOUN fnp-3682 102 10 of of ADP fnp-3682 102 11 pompe pompe PROPN fnp-3682 102 12 ’s ’s PART fnp-3682 102 13 disease disease NOUN fnp-3682 102 14 julien julien PROPN fnp-3682 102 15 gouju1 gouju1 PROPN fnp-3682 102 16 , , PUNCT fnp-3682 102 17 philippe philippe PROPN fnp-3682 102 18 codron1,2 codron1,2 PROPN fnp-3682 102 19 , , PUNCT fnp-3682 102 20 caroline caroline PROPN fnp-3682 102 21 savary1 savary1 PROPN fnp-3682 102 22 , , PUNCT fnp-3682 102 23 aleksandra aleksandra PROPN fnp-3682 102 24 nadaj nadaj NOUN fnp-3682 102 25 - - PUNCT fnp-3682 102 26 pakleza3 pakleza3 NOUN fnp-3682 102 27 , , PUNCT fnp-3682 102 28 marco marco PROPN fnp-3682 102 29 spinazzi1,2 spinazzi1,2 PROPN fnp-3682 102 30 , , PUNCT fnp-3682 102 31 franck franck X fnp-3682 102 32 letournel1 letournel1 PROPN fnp-3682 102 33 1 1 NUM fnp-3682 102 34 département département X fnp-3682 102 35 de de X fnp-3682 102 36 pathologie pathologie X fnp-3682 102 37 – – PUNCT fnp-3682 102 38 chu chu PROPN fnp-3682 102 39 angers anger NOUN fnp-3682 102 40 , , PUNCT fnp-3682 102 41 angers anger NOUN fnp-3682 102 42 , , PUNCT fnp-3682 102 43 france france PROPN fnp-3682 102 44 2 2 NUM fnp-3682 102 45 département département X fnp-3682 102 46 de de X fnp-3682 102 47 neurologie neurologie X fnp-3682 102 48 – – PUNCT fnp-3682 102 49 chu chu NOUN fnp-3682 102 50 angers anger NOUN fnp-3682 102 51 , , PUNCT fnp-3682 102 52 angers anger NOUN fnp-3682 102 53 , , PUNCT fnp-3682 102 54 france france PROPN fnp-3682 102 55 3 3 NUM fnp-3682 102 56 centre centre NOUN fnp-3682 102 57 de de X fnp-3682 102 58 référence référence PROPN fnp-3682 102 59 des des PROPN fnp-3682 102 60 maladies malady NOUN fnp-3682 102 61 neuromusculaires neuromusculaire VERB fnp-3682 102 62 nord nord PROPN fnp-3682 102 63 - - PUNCT fnp-3682 102 64 est est NOUN fnp-3682 102 65 - - PUNCT fnp-3682 102 66 ile ile PROPN fnp-3682 102 67 de de PROPN fnp-3682 102 68 france france PROPN fnp-3682 102 69 , , PUNCT fnp-3682 102 70 service service NOUN fnp-3682 102 71 de de X fnp-3682 102 72 neurologie neurologie X fnp-3682 102 73 , , PUNCT fnp-3682 102 74 hôpitaux hôpitaux NOUN fnp-3682 102 75 universitaires universitaire NOUN fnp-3682 102 76 de de X fnp-3682 102 77 strasbourg strasbourg NOUN fnp-3682 102 78 , , PUNCT fnp-3682 102 79 strasbourg strasbourg NOUN fnp-3682 102 80 , , PUNCT fnp-3682 102 81 france france PROPN fnp-3682 102 82 pompe pompe PROPN fnp-3682 102 83 ’s ’s PART fnp-3682 102 84 disease disease NOUN fnp-3682 102 85 is be AUX fnp-3682 102 86 a a DET fnp-3682 102 87 rare rare ADJ fnp-3682 102 88 autosomal autosomal ADJ fnp-3682 102 89 recessive recessive ADJ fnp-3682 102 90 disorder disorder NOUN fnp-3682 102 91 caused cause VERB fnp-3682 102 92 by by ADP fnp-3682 102 93 mutations mutation NOUN fnp-3682 102 94 in in ADP fnp-3682 102 95 the the DET fnp-3682 102 96 acid acid PROPN fnp-3682 102 97 α α NOUN fnp-3682 102 98 - - NOUN fnp-3682 102 99 glucosidase glucosidase ADJ fnp-3682 102 100 ( ( PUNCT fnp-3682 102 101 gaa gaa NOUN fnp-3682 102 102 ) ) PUNCT fnp-3682 102 103 gene gene NOUN fnp-3682 102 104 . . PUNCT fnp-3682 103 1 alpha alpha NOUN fnp-3682 103 2 - - PUNCT fnp-3682 103 3 glucosidase glucosidase ADJ fnp-3682 103 4 deficit deficit NOUN fnp-3682 103 5 leads lead VERB fnp-3682 103 6 to to ADP fnp-3682 103 7 lysosomal lysosomal ADJ fnp-3682 103 8 and and CCONJ fnp-3682 103 9 non non ADJ fnp-3682 103 10 - - ADJ fnp-3682 103 11 lysosomal lysosomal ADJ fnp-3682 103 12 accumulation accumulation NOUN fnp-3682 103 13 of of ADP fnp-3682 103 14 glycogen glycogen NOUN fnp-3682 103 15 with with ADP fnp-3682 103 16 different different ADJ fnp-3682 103 17 forms form NOUN fnp-3682 103 18 of of ADP fnp-3682 103 19 the the DET fnp-3682 103 20 disease disease NOUN fnp-3682 103 21 , , PUNCT fnp-3682 103 22 ranging range VERB fnp-3682 103 23 from from ADP fnp-3682 103 24 early early ADJ fnp-3682 103 25 - - PUNCT fnp-3682 103 26 onset onset NOUN fnp-3682 103 27 to to ADP fnp-3682 103 28 late late ADJ fnp-3682 103 29 - - PUNCT fnp-3682 103 30 onset onset NOUN fnp-3682 103 31 form form NOUN fnp-3682 103 32 ( ( PUNCT fnp-3682 103 33 lof lof PROPN fnp-3682 103 34 ) ) PUNCT fnp-3682 103 35 . . PUNCT fnp-3682 104 1 we we PRON fnp-3682 104 2 report report VERB fnp-3682 104 3 the the DET fnp-3682 104 4 case case NOUN fnp-3682 104 5 of of ADP fnp-3682 104 6 a a DET fnp-3682 104 7 lof lof NOUN fnp-3682 104 8 treated treat VERB fnp-3682 104 9 by by ADP fnp-3682 104 10 enzyme enzyme NOUN fnp-3682 104 11 replacement replacement NOUN fnp-3682 104 12 therapy therapy NOUN fnp-3682 104 13 ( ( PUNCT fnp-3682 104 14 ert ert PROPN fnp-3682 104 15 ) ) PUNCT fnp-3682 104 16 , , PUNCT fnp-3682 104 17 who who PRON fnp-3682 104 18 died die VERB fnp-3682 104 19 of of ADP fnp-3682 104 20 myocardial myocardial ADJ fnp-3682 104 21 infarct infarct NOUN fnp-3682 104 22 . . PUNCT fnp-3682 105 1 we we PRON fnp-3682 105 2 describe describe VERB fnp-3682 105 3 expression expression NOUN fnp-3682 105 4 of of ADP fnp-3682 105 5 several several ADJ fnp-3682 105 6 lysosomal lysosomal ADJ fnp-3682 105 7 and and CCONJ fnp-3682 105 8 autophagy autophagy ADJ fnp-3682 105 9 markers marker NOUN fnp-3682 105 10 in in ADP fnp-3682 105 11 several several ADJ fnp-3682 105 12 tissues tissue NOUN fnp-3682 105 13 . . PUNCT fnp-3682 106 1 we we PRON fnp-3682 106 2 observed observe VERB fnp-3682 106 3 a a DET fnp-3682 106 4 glycogen glycogen NOUN fnp-3682 106 5 - - PUNCT fnp-3682 106 6 accumulation accumulation NOUN fnp-3682 106 7 in in ADP fnp-3682 106 8 brain brain NOUN fnp-3682 106 9 , , PUNCT fnp-3682 106 10 associated associate VERB fnp-3682 106 11 to to ADP fnp-3682 106 12 increased increase VERB fnp-3682 106 13 expression expression NOUN fnp-3682 106 14 of of ADP fnp-3682 106 15 p62 p62 NOUN fnp-3682 106 16 , , PUNCT fnp-3682 106 17 lc3a lc3a PROPN fnp-3682 106 18 / / SYM fnp-3682 106 19 b b PROPN fnp-3682 106 20 and and CCONJ fnp-3682 106 21 lamp-2 lamp-2 PROPN fnp-3682 106 22 localized localize VERB fnp-3682 106 23 in in ADP fnp-3682 106 24 the the DET fnp-3682 106 25 neocortex neocortex NOUN fnp-3682 106 26 and and CCONJ fnp-3682 106 27 hippocampus hippocampus NOUN fnp-3682 106 28 . . PUNCT fnp-3682 107 1 both both DET fnp-3682 107 2 neurons neuron NOUN fnp-3682 107 3 and and CCONJ fnp-3682 107 4 glial glial ADJ fnp-3682 107 5 cells cell NOUN fnp-3682 107 6 were be AUX fnp-3682 107 7 affected affect VERB fnp-3682 107 8 , , PUNCT fnp-3682 107 9 however however ADV fnp-3682 107 10 cerebral cerebral ADJ fnp-3682 107 11 vessels vessel NOUN fnp-3682 107 12 were be AUX fnp-3682 107 13 normal normal ADJ fnp-3682 107 14 . . PUNCT fnp-3682 108 1 similar similar ADJ fnp-3682 108 2 results result NOUN fnp-3682 108 3 were be AUX fnp-3682 108 4 observed observe VERB fnp-3682 108 5 in in ADP fnp-3682 108 6 muscle muscle NOUN fnp-3682 108 7 , , PUNCT fnp-3682 108 8 heart heart NOUN fnp-3682 108 9 and and CCONJ fnp-3682 108 10 liver liver NOUN fnp-3682 108 11 . . PUNCT fnp-3682 109 1 our our PRON fnp-3682 109 2 data datum NOUN fnp-3682 109 3 suggest suggest VERB fnp-3682 109 4 that that SCONJ fnp-3682 109 5 autophagy autophagy ADJ fnp-3682 109 6 impairment impairment NOUN fnp-3682 109 7 could could AUX fnp-3682 109 8 be be AUX fnp-3682 109 9 an an DET fnp-3682 109 10 important important ADJ fnp-3682 109 11 pathogenic pathogenic ADJ fnp-3682 109 12 mechanism mechanism NOUN fnp-3682 109 13 in in ADP fnp-3682 109 14 the the DET fnp-3682 109 15 muscles muscle NOUN fnp-3682 109 16 and and CCONJ fnp-3682 109 17 the the DET fnp-3682 109 18 nervous nervous ADJ fnp-3682 109 19 system system NOUN fnp-3682 109 20 of of ADP fnp-3682 109 21 patients patient NOUN fnp-3682 109 22 with with ADP fnp-3682 109 23 pompe pompe PROPN fnp-3682 109 24 ’s ’s PART fnp-3682 109 25 disease disease NOUN fnp-3682 109 26         SPACE fnp-3682 109 27 free free ADJ fnp-3682 109 28 neuropathol neuropathol NOUN fnp-3682 109 29 2:32:19 2:32:19 NUM fnp-3682 109 30 diagnosis diagnosis NOUN fnp-3682 109 31 and and CCONJ fnp-3682 109 32 classification classification NOUN fnp-3682 109 33 of of ADP fnp-3682 109 34 peripheral peripheral ADJ fnp-3682 109 35 nerve nerve NOUN fnp-3682 109 36 vasculitis vasculitis NOUN fnp-3682 109 37 : : PUNCT fnp-3682 109 38 attempt attempt VERB fnp-3682 109 39 at at ADP fnp-3682 109 40 simplification simplification NOUN fnp-3682 109 41 bases basis NOUN fnp-3682 109 42 on on ADP fnp-3682 109 43 a a DET fnp-3682 109 44 retrospective retrospective ADJ fnp-3682 109 45 study study NOUN fnp-3682 109 46 at at ADP fnp-3682 109 47 limoges limoges PROPN fnp-3682 109 48 university university NOUN fnp-3682 109 49 hospital hospital NOUN fnp-3682 109 50 between between ADP fnp-3682 109 51 2014 2014 NUM fnp-3682 109 52 and and CCONJ fnp-3682 109 53 2020 2020 NUM fnp-3682 109 54 camille camille PROPN fnp-3682 109 55 guibert1 guibert1 PROPN fnp-3682 109 56 , , PUNCT fnp-3682 109 57 laurent laurent PROPN fnp-3682 109 58 magy2 magy2 PROPN fnp-3682 109 59 , , PUNCT fnp-3682 109 60 mathilde mathilde X fnp-3682 109 61 duchesne3 duchesne3 NOUN fnp-3682 109 62 1 1 NUM fnp-3682 109 63 service service NOUN fnp-3682 109 64 d’anatomie d’anatomie NOUN fnp-3682 109 65 pathologique pathologique NOUN fnp-3682 109 66 , , PUNCT fnp-3682 109 67 chu chu X fnp-3682 109 68 de de X fnp-3682 109 69 dijon dijon NOUN fnp-3682 109 70 , , PUNCT fnp-3682 109 71 france france PROPN fnp-3682 109 72 2 2 NUM fnp-3682 109 73 service service NOUN fnp-3682 109 74 de de X fnp-3682 109 75 neurologie neurologie X fnp-3682 109 76 , , PUNCT fnp-3682 109 77 chu chu PROPN fnp-3682 109 78 de de PROPN fnp-3682 109 79 limoges limoges PROPN fnp-3682 109 80 , , PUNCT fnp-3682 109 81 france france PROPN fnp-3682 109 82 3 3 NUM fnp-3682 109 83 service service NOUN fnp-3682 109 84 d’anatomie d’anatomie NOUN fnp-3682 109 85 pathologique pathologique NOUN fnp-3682 109 86 et et PROPN fnp-3682 109 87 laboratoire laboratoire PROPN fnp-3682 109 88 de de X fnp-3682 109 89 neurologie neurologie X fnp-3682 109 90 , , PUNCT fnp-3682 109 91 chu chu PROPN fnp-3682 109 92 de de PROPN fnp-3682 109 93 limoges limoges PROPN fnp-3682 109 94 , , PUNCT fnp-3682 109 95 france france PROPN fnp-3682 109 96 peripheral peripheral ADJ fnp-3682 109 97 nerve nerve NOUN fnp-3682 109 98 vasculitis vasculiti NOUN fnp-3682 109 99 remain remain VERB fnp-3682 109 100 rare rare ADJ fnp-3682 109 101 and and CCONJ fnp-3682 109 102 challenging challenging ADJ fnp-3682 109 103 to to PART fnp-3682 109 104 diagnose diagnose VERB fnp-3682 109 105 . . PUNCT fnp-3682 110 1 we we PRON fnp-3682 110 2 tried try VERB fnp-3682 110 3 to to PART fnp-3682 110 4 simplify simplify VERB fnp-3682 110 5 criteria criterion NOUN fnp-3682 110 6 of of ADP fnp-3682 110 7 the the DET fnp-3682 110 8 pns pns NOUN fnp-3682 110 9 2010 2010 NUM fnp-3682 110 10 by by ADP fnp-3682 110 11 searching search VERB fnp-3682 110 12 for for ADP fnp-3682 110 13 those those PRON fnp-3682 110 14 strongly strongly ADV fnp-3682 110 15 associated associate VERB fnp-3682 110 16 with with ADP fnp-3682 110 17 certain certain ADJ fnp-3682 110 18 and and CCONJ fnp-3682 110 19 probable probable ADJ fnp-3682 110 20 vasculitis vasculitis NOUN fnp-3682 110 21 , , PUNCT fnp-3682 110 22 and and CCONJ fnp-3682 110 23 to to PART fnp-3682 110 24 propose propose VERB fnp-3682 110 25 a a DET fnp-3682 110 26 management management NOUN fnp-3682 110 27 of of ADP fnp-3682 110 28 the the DET fnp-3682 110 29 biopsy biopsy NOUN fnp-3682 110 30 . . PUNCT fnp-3682 111 1 this this DET fnp-3682 111 2 retrospective retrospective ADJ fnp-3682 111 3 study study NOUN fnp-3682 111 4 included include VERB fnp-3682 111 5 46 46 NUM fnp-3682 111 6 patients patient NOUN fnp-3682 111 7 with with ADP fnp-3682 111 8 definite definite ADJ fnp-3682 111 9 and and CCONJ fnp-3682 111 10 probable probable ADJ fnp-3682 111 11 vasculitis vasculitis NOUN fnp-3682 111 12 according accord VERB fnp-3682 111 13 to to ADP fnp-3682 111 14 the the DET fnp-3682 111 15 criteria criterion NOUN fnp-3682 111 16 of of ADP fnp-3682 111 17 the the DET fnp-3682 111 18 pns pns PROPN fnp-3682 111 19 2010 2010 NUM fnp-3682 111 20 who who PRON fnp-3682 111 21 underwent undergo VERB fnp-3682 111 22 neuromuscular neuromuscular ADJ fnp-3682 111 23 biopsy biopsy NOUN fnp-3682 111 24 and and CCONJ fnp-3682 111 25 21 21 NUM fnp-3682 111 26 controls control NOUN fnp-3682 111 27 ( ( PUNCT fnp-3682 111 28 neurolymphomatosis neurolymphomatosis NOUN fnp-3682 111 29 and and CCONJ fnp-3682 111 30 cidp cidp NOUN fnp-3682 111 31 ) ) PUNCT fnp-3682 111 32 . . PUNCT fnp-3682 112 1 clinical clinical ADJ fnp-3682 112 2 , , PUNCT fnp-3682 112 3 biological biological ADJ fnp-3682 112 4 and and CCONJ fnp-3682 112 5 pathological pathological ADJ fnp-3682 112 6 features feature NOUN fnp-3682 112 7 were be AUX fnp-3682 112 8 collected collect VERB fnp-3682 112 9 . . PUNCT fnp-3682 113 1 criteria criterion NOUN fnp-3682 113 2 discriminating discriminate VERB fnp-3682 113 3 vasculitis vasculitis PROPN fnp-3682 113 4 from from ADP fnp-3682 113 5 controls control NOUN fnp-3682 113 6 were be AUX fnp-3682 113 7 asymmetry asymmetry NOUN fnp-3682 113 8 , , PUNCT fnp-3682 113 9 axonal axonal ADJ fnp-3682 113 10 involvement involvement NOUN fnp-3682 113 11 , , PUNCT fnp-3682 113 12 biological biological ADJ fnp-3682 113 13 inflammation inflammation NOUN fnp-3682 113 14 , , PUNCT fnp-3682 113 15 t t PROPN fnp-3682 113 16 cells cell NOUN fnp-3682 113 17 in in ADP fnp-3682 113 18 vessel vessel NOUN fnp-3682 113 19 wall wall NOUN fnp-3682 113 20 , , PUNCT fnp-3682 113 21 and and CCONJ fnp-3682 113 22 nerve nerve NOUN fnp-3682 113 23 haemosiderin haemosiderin NOUN fnp-3682 113 24 deposits deposit NOUN fnp-3682 113 25 . . PUNCT fnp-3682 114 1 two two NUM fnp-3682 114 2 criteria criterion NOUN fnp-3682 114 3 distinguish distinguish VERB fnp-3682 114 4 definite definite ADJ fnp-3682 114 5 and and CCONJ fnp-3682 114 6 probable probable ADJ fnp-3682 114 7 vasculitis vasculitis NOUN fnp-3682 114 8 : : PUNCT fnp-3682 114 9 ovoid ovoid ADJ fnp-3682 114 10 and and CCONJ fnp-3682 114 11 endoneurial endoneurial ADJ fnp-3682 114 12 haemosiderin haemosiderin ADJ fnp-3682 114 13 deposits deposit NOUN fnp-3682 114 14 . . PUNCT fnp-3682 115 1 the the DET fnp-3682 115 2 techniques technique NOUN fnp-3682 115 3 useful useful ADJ fnp-3682 115 4 for for ADP fnp-3682 115 5 pathological pathological ADJ fnp-3682 115 6 diagnosis diagnosis NOUN fnp-3682 115 7 are be AUX fnp-3682 115 8 serial serial ADJ fnp-3682 115 9 cuts cut NOUN fnp-3682 115 10 , , PUNCT fnp-3682 115 11 typing type VERB fnp-3682 115 12 of of ADP fnp-3682 115 13 inflammatory inflammatory ADJ fnp-3682 115 14 elements element NOUN fnp-3682 115 15 and and CCONJ fnp-3682 115 16 perls perl NOUN fnp-3682 115 17 staining stain VERB fnp-3682 115 18 . . PUNCT fnp-3682 116 1 we we PRON fnp-3682 116 2 proposed propose VERB fnp-3682 116 3 a a DET fnp-3682 116 4 slightly slightly ADV fnp-3682 116 5 simplified simplified ADJ fnp-3682 116 6 classification classification NOUN fnp-3682 116 7 of of ADP fnp-3682 116 8 vasculitis vasculitis NOUN fnp-3682 116 9 according accord VERB fnp-3682 116 10 to to ADP fnp-3682 116 11 the the DET fnp-3682 116 12 pns pns NOUN fnp-3682 116 13 2010 2010 NUM fnp-3682 116 14 and and CCONJ fnp-3682 116 15 a a DET fnp-3682 116 16 management management NOUN fnp-3682 116 17 of of ADP fnp-3682 116 18 neuromuscular neuromuscular ADJ fnp-3682 116 19 biopsy biopsy NOUN fnp-3682 116 20 in in ADP fnp-3682 116 21 this this DET fnp-3682 116 22 indication indication NOUN fnp-3682 116 23 . . PUNCT fnp-3682 116 24         SPACE fnp-3682 117 1 free free ADJ fnp-3682 117 2 neuropathol neuropathol NOUN fnp-3682 117 3 2:32:20 2:32:20 NUM fnp-3682 117 4 experimental experimental ADJ fnp-3682 117 5 evaluation evaluation NOUN fnp-3682 117 6 of of ADP fnp-3682 117 7 myosuppressive myosuppressive ADJ fnp-3682 117 8 effects effect NOUN fnp-3682 117 9 of of ADP fnp-3682 117 10 ifn ifn PROPN fnp-3682 117 11 - - PUNCT fnp-3682 117 12 gamma gamma NOUN fnp-3682 117 13 cyrielle cyrielle PROPN fnp-3682 117 14 hou1 hou1 PROPN fnp-3682 117 15 ; ; PUNCT fnp-3682 117 16 baptiste baptiste ADJ fnp-3682 117 17 périou1 périou1 NOUN fnp-3682 117 18 , , PUNCT fnp-3682 117 19 marianne marianne PROPN fnp-3682 117 20 gervais1 gervais1 PROPN fnp-3682 117 21 , , PUNCT fnp-3682 117 22 juliette juliette PROPN fnp-3682 117 23 berthier1 berthier1 PROPN fnp-3682 117 24 , , PUNCT fnp-3682 117 25 yasmine yasmine PROPN fnp-3682 117 26 baba baba PROPN fnp-3682 117 27 - - PUNCT fnp-3682 117 28 amer1 amer1 PROPN fnp-3682 117 29 , , PUNCT fnp-3682 117 30 sarah sarah PROPN fnp-3682 117 31 souvannanorath1,2 souvannanorath1,2 PROPN fnp-3682 117 32 , , PUNCT fnp-3682 117 33 edoardo edoardo PROPN fnp-3682 117 34 malfatti1,2 malfatti1,2 PROPN fnp-3682 117 35 , , PUNCT fnp-3682 117 36 frédéric frédéric ADJ fnp-3682 117 37 relaix1,2 relaix1,2 PROPN fnp-3682 117 38 , , PUNCT fnp-3682 117 39 françois françois PROPN fnp-3682 117 40 jérôme jérôme PROPN fnp-3682 117 41 authier1,2 authier1,2 PROPN fnp-3682 117 42 1 1 NUM fnp-3682 117 43 inserm inserm NOUN fnp-3682 117 44 u955 u955 NUM fnp-3682 117 45 - - PUNCT fnp-3682 117 46 eq eq NOUN fnp-3682 117 47 . . PUNCT fnp-3682 118 1 relaix relaix PROPN fnp-3682 118 2 , , PUNCT fnp-3682 118 3 faculté faculté PROPN fnp-3682 118 4 de de X fnp-3682 118 5 santé santé PROPN fnp-3682 118 6 , , PUNCT fnp-3682 118 7 université université PROPN fnp-3682 118 8 paris paris PROPN fnp-3682 118 9 est est X fnp-3682 118 10 - - PUNCT fnp-3682 118 11 créteil créteil NOUN fnp-3682 118 12 ; ; PUNCT fnp-3682 118 13 créteil créteil NOUN fnp-3682 118 14 , , PUNCT fnp-3682 118 15 france france PROPN fnp-3682 118 16 2 2 NUM fnp-3682 118 17 hu hu PROPN fnp-3682 118 18 henri henri PROPN fnp-3682 118 19 mondor mondor PROPN fnp-3682 118 20 ( ( PUNCT fnp-3682 118 21 aphp aphp PROPN fnp-3682 118 22 ) ) PUNCT fnp-3682 118 23 , , PUNCT fnp-3682 118 24 centre centre NOUN fnp-3682 118 25 de de X fnp-3682 118 26 référence référence PROPN fnp-3682 118 27 des des PROPN fnp-3682 118 28 maladies malady NOUN fnp-3682 118 29 neuromusculaires neuromusculaire NOUN fnp-3682 118 30 , , PUNCT fnp-3682 118 31 département département PROPN fnp-3682 118 32 de de X fnp-3682 118 33 pathologie pathologie PROPN fnp-3682 118 34 , , PUNCT fnp-3682 118 35 créteil créteil PROPN fnp-3682 118 36 , , PUNCT fnp-3682 118 37 france france PROPN fnp-3682 118 38 dysimmune dysimmune NOUN fnp-3682 118 39 and and CCONJ fnp-3682 118 40 inflammatory inflammatory ADJ fnp-3682 118 41 myopathies myopathy NOUN fnp-3682 118 42 ( ( PUNCT fnp-3682 118 43 dims dim NOUN fnp-3682 118 44 ) ) PUNCT fnp-3682 118 45 are be AUX fnp-3682 118 46 acquired acquire VERB fnp-3682 118 47 idiopathic idiopathic ADJ fnp-3682 118 48 myopathy myopathy NOUN fnp-3682 118 49 associated associate VERB fnp-3682 118 50 with with ADP fnp-3682 118 51 immune immune ADJ fnp-3682 118 52 response response NOUN fnp-3682 118 53 dysregulation dysregulation NOUN fnp-3682 118 54 . . PUNCT fnp-3682 119 1 inclusion inclusion NOUN fnp-3682 119 2 body body NOUN fnp-3682 119 3 myositis myositis PROPN fnp-3682 119 4 ( ( PUNCT fnp-3682 119 5 ibm ibm PROPN fnp-3682 119 6 ) ) PUNCT fnp-3682 119 7 , , PUNCT fnp-3682 119 8 the the DET fnp-3682 119 9 most most ADV fnp-3682 119 10 common common ADJ fnp-3682 119 11 dims dim NOUN fnp-3682 119 12 , , PUNCT fnp-3682 119 13 is be AUX fnp-3682 119 14 characterized characterize VERB fnp-3682 119 15 by by ADP fnp-3682 119 16 endomysial endomysial ADJ fnp-3682 119 17 infiltrates infiltrate NOUN fnp-3682 119 18 of of ADP fnp-3682 119 19 cytotoxic cytotoxic ADJ fnp-3682 119 20 t t NOUN fnp-3682 119 21 lymphocytes lymphocyte VERB fnp-3682 119 22 cd8 cd8 PROPN fnp-3682 119 23 , , PUNCT fnp-3682 119 24 muscle muscle NOUN fnp-3682 119 25 type type NOUN fnp-3682 119 26 ii ii PROPN fnp-3682 119 27 - - NOUN fnp-3682 119 28 interferon interferon ADJ fnp-3682 119 29 ( ( PUNCT fnp-3682 119 30 ifnγ ifnγ NOUN fnp-3682 119 31 ) ) PUNCT fnp-3682 119 32 signature signature NOUN fnp-3682 119 33 , , PUNCT fnp-3682 119 34 and and CCONJ fnp-3682 119 35 by by ADP fnp-3682 119 36 the the DET fnp-3682 119 37 lack lack NOUN fnp-3682 119 38 of of ADP fnp-3682 119 39 response response NOUN fnp-3682 119 40 to to ADP fnp-3682 119 41 immunomodulatory immunomodulatory ADJ fnp-3682 119 42 therapies therapy NOUN fnp-3682 119 43 . . PUNCT fnp-3682 120 1 we we PRON fnp-3682 120 2 showed show VERB fnp-3682 120 3 that that SCONJ fnp-3682 120 4 ibm ibm PROPN fnp-3682 120 5 differs differ VERB fnp-3682 120 6 from from ADP fnp-3682 120 7 other other ADJ fnp-3682 120 8 myopathies myopathy NOUN fnp-3682 120 9 by by ADP fnp-3682 120 10 the the DET fnp-3682 120 11 presence presence NOUN fnp-3682 120 12 of of ADP fnp-3682 120 13 chronic chronic ADJ fnp-3682 120 14 degenerative degenerative ADJ fnp-3682 120 15 myopathic myopathic ADJ fnp-3682 120 16 features feature NOUN fnp-3682 120 17 including include VERB fnp-3682 120 18 the the DET fnp-3682 120 19 altered altered ADJ fnp-3682 120 20 functions function NOUN fnp-3682 120 21 of of ADP fnp-3682 120 22 skeletal skeletal ADJ fnp-3682 120 23 muscle muscle NOUN fnp-3682 120 24 stem stem NOUN fnp-3682 120 25 cells cell NOUN fnp-3682 120 26 . . PUNCT fnp-3682 121 1 here here ADV fnp-3682 121 2 , , PUNCT fnp-3682 121 3 we we PRON fnp-3682 121 4 demonstrated demonstrate VERB fnp-3682 121 5 that that SCONJ fnp-3682 121 6 , , PUNCT fnp-3682 121 7 in in ADP fnp-3682 121 8 vitro vitro X fnp-3682 121 9 , , PUNCT fnp-3682 121 10 protracted protract VERB fnp-3682 121 11 ifnγ ifnγ NOUN fnp-3682 121 12 treatment treatment NOUN fnp-3682 121 13 inhibits inhibit VERB fnp-3682 121 14 the the DET fnp-3682 121 15 activation activation NOUN fnp-3682 121 16 , , PUNCT fnp-3682 121 17 proliferation proliferation NOUN fnp-3682 121 18 , , PUNCT fnp-3682 121 19 migration migration NOUN fnp-3682 121 20 , , PUNCT fnp-3682 121 21 differentiation differentiation NOUN fnp-3682 121 22 , , PUNCT fnp-3682 121 23 and and CCONJ fnp-3682 121 24 fusion fusion NOUN fnp-3682 121 25 of of ADP fnp-3682 121 26 myogenic myogenic ADJ fnp-3682 121 27 progenitor progenitor NOUN fnp-3682 121 28 cells cell NOUN fnp-3682 121 29 and and CCONJ fnp-3682 121 30 promotes promote VERB fnp-3682 121 31 their their PRON fnp-3682 121 32 senescence senescence NOUN fnp-3682 121 33 through through ADP fnp-3682 121 34 jak jak PROPN fnp-3682 121 35 - - PUNCT fnp-3682 121 36 stat stat NOUN fnp-3682 121 37 - - PUNCT fnp-3682 121 38 dependent dependent ADJ fnp-3682 121 39 activation activation NOUN fnp-3682 121 40 . . PUNCT fnp-3682 122 1 jak jak PROPN fnp-3682 122 2 - - PUNCT fnp-3682 122 3 stat stat PROPN fnp-3682 122 4 inhibitor inhibitor NOUN fnp-3682 122 5 , , PUNCT fnp-3682 122 6 ruxolitinib ruxolitinib NOUN fnp-3682 122 7 abrogates abrogate VERB fnp-3682 122 8 the the DET fnp-3682 122 9 deleterious deleterious ADJ fnp-3682 122 10 effects effect NOUN fnp-3682 122 11 of of ADP fnp-3682 122 12 ifnγ ifnγ NOUN fnp-3682 122 13 , , PUNCT fnp-3682 122 14 in in ADP fnp-3682 122 15 conclusion conclusion NOUN fnp-3682 122 16 , , PUNCT fnp-3682 122 17 our our PRON fnp-3682 122 18 results result NOUN fnp-3682 122 19 indicate indicate VERB fnp-3682 122 20 that that SCONJ fnp-3682 122 21 ifnγ ifnγ NOUN fnp-3682 122 22 could could AUX fnp-3682 122 23 impair impair VERB fnp-3682 122 24 muscle muscle NOUN fnp-3682 122 25 regeneration regeneration NOUN fnp-3682 122 26 in in ADP fnp-3682 122 27 the the DET fnp-3682 122 28 context context NOUN fnp-3682 122 29 of of ADP fnp-3682 122 30 inflammatory inflammatory ADJ fnp-3682 122 31 myopathies myopathy NOUN fnp-3682 122 32 and and CCONJ fnp-3682 122 33 that that SCONJ fnp-3682 122 34 jak jak PROPN fnp-3682 122 35 inhibitors inhibitor NOUN fnp-3682 122 36 could could AUX fnp-3682 122 37 represent represent VERB fnp-3682 122 38 interesting interesting ADJ fnp-3682 122 39 therapies therapy NOUN fnp-3682 122 40 for for ADP fnp-3682 122 41 immune immune ADJ fnp-3682 122 42 myopathies myopathy NOUN fnp-3682 122 43 with with ADP fnp-3682 122 44 ifnγ ifnγ NOUN fnp-3682 122 45 signature signature NOUN fnp-3682 122 46 . . PUNCT fnp-3682 122 47     SPACE fnp-3682 123 1 copyright copyright NOUN fnp-3682 123 2 : : PUNCT fnp-3682 123 3 © © PROPN fnp-3682 123 4 2021 2021 NUM fnp-3682 123 5 the the DET fnp-3682 123 6 author(s author(s NOUN fnp-3682 123 7 ) ) PUNCT fnp-3682 123 8 . . PUNCT fnp-3682 124 1 this this PRON fnp-3682 124 2 is be AUX fnp-3682 124 3 an an DET fnp-3682 124 4 open open ADJ fnp-3682 124 5 access access NOUN fnp-3682 124 6 article article NOUN fnp-3682 124 7 distributed distribute VERB fnp-3682 124 8 under under ADP fnp-3682 124 9 the the DET fnp-3682 124 10 terms term NOUN fnp-3682 124 11 of of ADP fnp-3682 124 12 the the DET fnp-3682 124 13 creative creative ADJ fnp-3682 124 14 commons common NOUN fnp-3682 124 15 attribution attribution NOUN fnp-3682 124 16 4.0 4.0 NUM fnp-3682 124 17 international international ADJ fnp-3682 124 18 license license NOUN fnp-3682 124 19 ( ( PUNCT fnp-3682 124 20 https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/ PROPN fnp-3682 124 21 ) ) PUNCT fnp-3682 124 22 , , PUNCT fnp-3682 124 23 which which PRON fnp-3682 124 24 permits permit VERB fnp-3682 124 25 unrestricted unrestricted ADJ fnp-3682 124 26 use use NOUN fnp-3682 124 27 , , PUNCT fnp-3682 124 28 distribution distribution NOUN fnp-3682 124 29 , , PUNCT fnp-3682 124 30 and and CCONJ fnp-3682 124 31 reproduction reproduction NOUN fnp-3682 124 32 in in ADP fnp-3682 124 33 any any DET fnp-3682 124 34 medium medium NOUN fnp-3682 124 35 , , PUNCT fnp-3682 124 36 provided provide VERB fnp-3682 124 37 the the DET fnp-3682 124 38 original original ADJ fnp-3682 124 39 author author NOUN fnp-3682 124 40 and and CCONJ fnp-3682 124 41 source source NOUN fnp-3682 124 42 are be AUX fnp-3682 124 43 credited credit VERB fnp-3682 124 44 , , PUNCT fnp-3682 124 45 a a DET fnp-3682 124 46 link link NOUN fnp-3682 124 47 to to ADP fnp-3682 124 48 the the DET fnp-3682 124 49 creative creative ADJ fnp-3682 124 50 commons common NOUN fnp-3682 124 51 license license NOUN fnp-3682 124 52 is be AUX fnp-3682 124 53 provided provide VERB fnp-3682 124 54 , , PUNCT fnp-3682 124 55 and and CCONJ fnp-3682 124 56 any any DET fnp-3682 124 57 changes change NOUN fnp-3682 124 58 are be AUX fnp-3682 124 59 indicated indicate VERB fnp-3682 124 60 . . PUNCT fnp-3682 125 1 the the DET fnp-3682 125 2 creative creative ADJ fnp-3682 125 3 commons common NOUN fnp-3682 125 4 public public ADJ fnp-3682 125 5 domain domain NOUN fnp-3682 125 6 dedication dedication NOUN fnp-3682 125 7 waiver waiver NOUN fnp-3682 125 8 ( ( PUNCT fnp-3682 125 9 https://creativecommons.org/publicdomain/zero/1.0/ https://creativecommons.org/publicdomain/zero/1.0/ PROPN fnp-3682 125 10 ) ) PUNCT fnp-3682 125 11 applies apply VERB fnp-3682 125 12 to to ADP fnp-3682 125 13 the the DET fnp-3682 125 14 data datum NOUN fnp-3682 125 15 made make VERB fnp-3682 125 16 available available ADJ fnp-3682 125 17 in in ADP fnp-3682 125 18 this this DET fnp-3682 125 19 article article NOUN fnp-3682 125 20 , , PUNCT fnp-3682 125 21 unless unless SCONJ fnp-3682 125 22 otherwise otherwise ADV fnp-3682 125 23 stated state VERB fnp-3682 125 24 . . PUNCT