id sid tid token lemma pos fnp-3684 1 1 medulloblastoma medulloblastoma PROPN fnp-3684 1 2 and and CCONJ fnp-3684 1 3 cowden cowden PROPN fnp-3684 1 4 syndrome syndrome PROPN fnp-3684 1 5 : : PUNCT fnp-3684 1 6 further further ADJ fnp-3684 1 7 evidence evidence NOUN fnp-3684 1 8 of of ADP fnp-3684 1 9 an an DET fnp-3684 1 10 association association NOUN fnp-3684 1 11 feel feel VERB fnp-3684 1 12 free free ADJ fnp-3684 1 13 to to PART fnp-3684 1 14 add add VERB fnp-3684 1 15 comments comment NOUN fnp-3684 1 16 by by ADP fnp-3684 1 17 clicking click VERB fnp-3684 1 18 these these DET fnp-3684 1 19 icons icon NOUN fnp-3684 1 20 on on ADP fnp-3684 1 21 the the DET fnp-3684 1 22 sidebar sidebar NOUN fnp-3684 1 23 free free PROPN fnp-3684 1 24 neuropathology neuropathology NOUN fnp-3684 1 25 3:1 3:1 NUM fnp-3684 1 26 ( ( PUNCT fnp-3684 1 27 2022 2022 NUM fnp-3684 1 28 ) ) PUNCT fnp-3684 1 29 case case NOUN fnp-3684 1 30 report report NOUN fnp-3684 1 31 medulloblastoma medulloblastoma NOUN fnp-3684 1 32 and and CCONJ fnp-3684 1 33 cowden cowden PROPN fnp-3684 1 34 syndrome syndrome PROPN fnp-3684 1 35 : : PUNCT fnp-3684 1 36 further further ADJ fnp-3684 1 37 evidence evidence NOUN fnp-3684 1 38 of of ADP fnp-3684 1 39 an an DET fnp-3684 1 40 association association NOUN fnp-3684 1 41 steffen steffen PROPN fnp-3684 1 42 albrecht1 albrecht1 PROPN fnp-3684 1 43 , , PUNCT fnp-3684 1 44 * * PUNCT fnp-3684 1 45 , , PUNCT fnp-3684 1 46 barbara barbara PROPN fnp-3684 1 47 miedzybrodzki2 miedzybrodzki2 PROPN fnp-3684 1 48 , , PUNCT fnp-3684 1 49 laura laura PROPN fnp-3684 1 50 palma3,4 palma3,4 PROPN fnp-3684 1 51 , , PUNCT fnp-3684 1 52 van van PROPN fnp-3684 1 53 hung hung PROPN fnp-3684 1 54 nguyen1 nguyen1 PROPN fnp-3684 1 55 , , PUNCT fnp-3684 1 56 roy roy PROPN fnp-3684 1 57 w.r w.r PROPN fnp-3684 1 58 . . PROPN fnp-3684 2 1 dudley5 dudley5 PROPN fnp-3684 2 2 , , PUNCT fnp-3684 2 3 torsten torsten PROPN fnp-3684 2 4 pietsch6 pietsch6 PROPN fnp-3684 2 5 , , PUNCT fnp-3684 2 6 tobias tobias PROPN fnp-3684 2 7 goschzik6 goschzik6 PROPN fnp-3684 2 8 , , PUNCT fnp-3684 2 9 nada nada PROPN fnp-3684 2 10 jabado3,7,8 jabado3,7,8 PROPN fnp-3684 2 11 , , PUNCT fnp-3684 2 12 catherine catherine PROPN fnp-3684 2 13 goudie8,9 goudie8,9 PROPN fnp-3684 2 14 , , PUNCT fnp-3684 2 15 william william PROPN fnp-3684 2 16 d. d. PROPN fnp-3684 2 17 foulkes3,10,11,12 foulkes3,10,11,12 PROPN fnp-3684 2 18 1 1 NUM fnp-3684 2 19 department department NOUN fnp-3684 2 20 of of ADP fnp-3684 2 21 pathology pathology PROPN fnp-3684 2 22 , , PUNCT fnp-3684 2 23 mcgill mcgill PROPN fnp-3684 2 24 university university PROPN fnp-3684 2 25 , , PUNCT fnp-3684 2 26 montreal montreal PROPN fnp-3684 2 27 , , PUNCT fnp-3684 2 28 qc qc PROPN fnp-3684 2 29 , , PUNCT fnp-3684 2 30 canada canada PROPN fnp-3684 2 31 2 2 NUM fnp-3684 2 32 division division NOUN fnp-3684 2 33 of of ADP fnp-3684 2 34 dermatology dermatology NOUN fnp-3684 2 35 , , PUNCT fnp-3684 2 36 department department NOUN fnp-3684 2 37 of of ADP fnp-3684 2 38 pediatrics pediatric NOUN fnp-3684 2 39 , , PUNCT fnp-3684 2 40 mcgill mcgill PROPN fnp-3684 2 41 university university PROPN fnp-3684 2 42 health health PROPN fnp-3684 2 43 centre centre PROPN fnp-3684 2 44 , , PUNCT fnp-3684 2 45 montreal montreal PROPN fnp-3684 2 46 children child NOUN fnp-3684 2 47 's 's PART fnp-3684 2 48 hospital hospital NOUN fnp-3684 2 49 , , PUNCT fnp-3684 2 50 montreal montreal PROPN fnp-3684 2 51 , , PUNCT fnp-3684 2 52 qc qc PROPN fnp-3684 2 53 , , PUNCT fnp-3684 2 54 canada canada PROPN fnp-3684 2 55 3 3 NUM fnp-3684 2 56 department department PROPN fnp-3684 2 57 of of ADP fnp-3684 2 58 human human ADJ fnp-3684 2 59 genetics genetics PROPN fnp-3684 2 60 , , PUNCT fnp-3684 2 61 mcgill mcgill PROPN fnp-3684 2 62 university university PROPN fnp-3684 2 63 , , PUNCT fnp-3684 2 64 montreal montreal PROPN fnp-3684 2 65 , , PUNCT fnp-3684 2 66 qc qc PROPN fnp-3684 2 67 , , PUNCT fnp-3684 2 68 canada canada PROPN fnp-3684 2 69 4 4 NUM fnp-3684 2 70 division division NOUN fnp-3684 2 71 of of ADP fnp-3684 2 72 medical medical ADJ fnp-3684 2 73 genetics genetic NOUN fnp-3684 2 74 , , PUNCT fnp-3684 2 75 department department NOUN fnp-3684 2 76 of of ADP fnp-3684 2 77 specialized specialized ADJ fnp-3684 2 78 medicine medicine NOUN fnp-3684 2 79 , , PUNCT fnp-3684 2 80 mcgill mcgill PROPN fnp-3684 2 81 university university PROPN fnp-3684 2 82 health health PROPN fnp-3684 2 83 centre centre PROPN fnp-3684 2 84 , , PUNCT fnp-3684 2 85 montreal montreal PROPN fnp-3684 2 86 , , PUNCT fnp-3684 2 87 qc qc PROPN fnp-3684 2 88 , , PUNCT fnp-3684 2 89 canada canada PROPN fnp-3684 2 90 5 5 NUM fnp-3684 2 91 division division NOUN fnp-3684 2 92 of of ADP fnp-3684 2 93 neurosurgery neurosurgery NOUN fnp-3684 2 94 , , PUNCT fnp-3684 2 95 department department NOUN fnp-3684 2 96 of of ADP fnp-3684 2 97 pediatric pediatric ADJ fnp-3684 2 98 surgery surgery NOUN fnp-3684 2 99 , , PUNCT fnp-3684 2 100 montreal montreal PROPN fnp-3684 2 101 children child NOUN fnp-3684 2 102 's 's PART fnp-3684 2 103 hospital hospital NOUN fnp-3684 2 104 , , PUNCT fnp-3684 2 105 mcgill mcgill PROPN fnp-3684 2 106 university university PROPN fnp-3684 2 107 health health PROPN fnp-3684 2 108 centre centre PROPN fnp-3684 2 109 , , PUNCT fnp-3684 2 110 montreal montreal PROPN fnp-3684 2 111 , , PUNCT fnp-3684 2 112 qc qc PROPN fnp-3684 2 113 , , PUNCT fnp-3684 2 114 canada canada PROPN fnp-3684 2 115 6 6 NUM fnp-3684 2 116 department department NOUN fnp-3684 2 117 of of ADP fnp-3684 2 118 neuropathology neuropathology NOUN fnp-3684 2 119 , , PUNCT fnp-3684 2 120 dgnn dgnn NOUN fnp-3684 2 121 brain brain NOUN fnp-3684 2 122 tumor tumor PROPN fnp-3684 2 123 reference reference NOUN fnp-3684 2 124 center center NOUN fnp-3684 2 125 , , PUNCT fnp-3684 2 126 university university NOUN fnp-3684 2 127 of of ADP fnp-3684 2 128 bonn bonn PROPN fnp-3684 2 129 medical medical ADJ fnp-3684 2 130 center center NOUN fnp-3684 2 131 , , PUNCT fnp-3684 2 132 bonn bonn PROPN fnp-3684 2 133 , , PUNCT fnp-3684 2 134 germany germany PROPN fnp-3684 2 135 7 7 NUM fnp-3684 2 136 department department NOUN fnp-3684 2 137 of of ADP fnp-3684 2 138 pediatrics pediatric NOUN fnp-3684 2 139 , , PUNCT fnp-3684 2 140 mcgill mcgill PROPN fnp-3684 2 141 university university PROPN fnp-3684 2 142 , , PUNCT fnp-3684 2 143 montreal montreal PROPN fnp-3684 2 144 , , PUNCT fnp-3684 2 145 qc qc PROPN fnp-3684 2 146 , , PUNCT fnp-3684 2 147 canada canada PROPN fnp-3684 2 148 8 8 NUM fnp-3684 2 149 the the DET fnp-3684 2 150 research research PROPN fnp-3684 2 151 institute institute PROPN fnp-3684 2 152 of of ADP fnp-3684 2 153 the the DET fnp-3684 2 154 mcgill mcgill PROPN fnp-3684 2 155 university university PROPN fnp-3684 2 156 health health NOUN fnp-3684 2 157 centre centre NOUN fnp-3684 2 158 , , PUNCT fnp-3684 2 159 child child NOUN fnp-3684 2 160 health health NOUN fnp-3684 2 161 and and CCONJ fnp-3684 2 162 human human PROPN fnp-3684 2 163 development development PROPN fnp-3684 2 164 program program PROPN fnp-3684 2 165 , , PUNCT fnp-3684 2 166 montreal montreal PROPN fnp-3684 2 167 , , PUNCT fnp-3684 2 168 qc qc PROPN fnp-3684 2 169 , , PUNCT fnp-3684 2 170 canada canada PROPN fnp-3684 2 171 9 9 NUM fnp-3684 2 172 division division NOUN fnp-3684 2 173 of of ADP fnp-3684 2 174 hematology hematology NOUN fnp-3684 2 175 - - PUNCT fnp-3684 2 176 oncology oncology NOUN fnp-3684 2 177 , , PUNCT fnp-3684 2 178 montreal montreal PROPN fnp-3684 2 179 children child NOUN fnp-3684 2 180 's 's PART fnp-3684 2 181 hospital hospital NOUN fnp-3684 2 182 , , PUNCT fnp-3684 2 183 department department NOUN fnp-3684 2 184 of of ADP fnp-3684 2 185 pediatrics pediatric NOUN fnp-3684 2 186 , , PUNCT fnp-3684 2 187 mcgill mcgill PROPN fnp-3684 2 188 university university PROPN fnp-3684 2 189 , , PUNCT fnp-3684 2 190 montreal montreal PROPN fnp-3684 2 191 , , PUNCT fnp-3684 2 192 qc qc PROPN fnp-3684 2 193 , , PUNCT fnp-3684 2 194 canada canada PROPN fnp-3684 2 195 10 10 NUM fnp-3684 2 196 cancer cancer NOUN fnp-3684 2 197 axis axis NOUN fnp-3684 2 198 , , PUNCT fnp-3684 2 199 lady lady PROPN fnp-3684 2 200 davis davis PROPN fnp-3684 2 201 institute institute PROPN fnp-3684 2 202 , , PUNCT fnp-3684 2 203 the the DET fnp-3684 2 204 jewish jewish ADJ fnp-3684 2 205 general general ADJ fnp-3684 2 206 hospital hospital PROPN fnp-3684 2 207 , , PUNCT fnp-3684 2 208 montreal montreal PROPN fnp-3684 2 209 , , PUNCT fnp-3684 2 210 qc qc PROPN fnp-3684 2 211 , , PUNCT fnp-3684 2 212 canada canada PROPN fnp-3684 2 213 11 11 NUM fnp-3684 2 214 cancer cancer NOUN fnp-3684 2 215 research research NOUN fnp-3684 2 216 program program NOUN fnp-3684 2 217 , , PUNCT fnp-3684 2 218 the the DET fnp-3684 2 219 research research PROPN fnp-3684 2 220 institute institute PROPN fnp-3684 2 221 of of ADP fnp-3684 2 222 the the DET fnp-3684 2 223 mcgill mcgill PROPN fnp-3684 2 224 university university PROPN fnp-3684 2 225 health health PROPN fnp-3684 2 226 centre centre PROPN fnp-3684 2 227 , , PUNCT fnp-3684 2 228 montreal montreal PROPN fnp-3684 2 229 , , PUNCT fnp-3684 2 230 qc qc PROPN fnp-3684 2 231 , , PUNCT fnp-3684 2 232 canada canada PROPN fnp-3684 2 233 12 12 NUM fnp-3684 2 234 gerald gerald PROPN fnp-3684 2 235 bronfman bronfman PROPN fnp-3684 2 236 department department PROPN fnp-3684 2 237 of of ADP fnp-3684 2 238 oncology oncology PROPN fnp-3684 2 239 , , PUNCT fnp-3684 2 240 mcgill mcgill PROPN fnp-3684 2 241 university university PROPN fnp-3684 2 242 , , PUNCT fnp-3684 2 243 montreal montreal PROPN fnp-3684 2 244 , , PUNCT fnp-3684 2 245 qc qc PROPN fnp-3684 2 246 , , PUNCT fnp-3684 2 247 canada canada PROPN fnp-3684 2 248 * * PUNCT fnp-3684 2 249 retired retire VERB fnp-3684 2 250 since since SCONJ fnp-3684 2 251 aug aug PROPN fnp-3684 2 252 . . PROPN fnp-3684 2 253 2021 2021 NUM fnp-3684 2 254 corresponding correspond VERB fnp-3684 2 255 author author NOUN fnp-3684 2 256 : : PUNCT fnp-3684 2 257 steffen steffen PROPN fnp-3684 2 258 albrecht albrecht PROPN fnp-3684 2 259 · · PUNCT fnp-3684 2 260 511 511 NUM fnp-3684 2 261 - - SYM fnp-3684 2 262 244 244 NUM fnp-3684 2 263 sherbrooke sherbrooke PROPN fnp-3684 2 264 street street PROPN fnp-3684 2 265 east east PROPN fnp-3684 2 266 · · PUNCT fnp-3684 2 267 montreal montreal PROPN fnp-3684 2 268 , , PUNCT fnp-3684 2 269 qc qc PROPN fnp-3684 2 270 · · PUNCT fnp-3684 2 271 h2x h2x PROPN fnp-3684 2 272 1e1 1e1 NUM fnp-3684 2 273 · · PUNCT fnp-3684 2 274 canada canada PROPN fnp-3684 2 275 steffen.albrecht@hotmail.com steffen.albrecht@hotmail.com PROPN fnp-3684 2 276 submitted submit VERB fnp-3684 2 277 : : PUNCT fnp-3684 2 278 02 02 NUM fnp-3684 2 279 december december PROPN fnp-3684 2 280 2021 2021 NUM fnp-3684 2 281 accepted accept VERB fnp-3684 2 282 : : PUNCT fnp-3684 2 283 02 02 NUM fnp-3684 2 284 january january PROPN fnp-3684 2 285 2022 2022 NUM fnp-3684 2 286 copyedited copyedit VERB fnp-3684 2 287 by by ADP fnp-3684 2 288 : : PUNCT fnp-3684 2 289 jeffrey jeffrey PROPN fnp-3684 2 290 nirschl nirschl PROPN fnp-3684 2 291 published publish VERB fnp-3684 2 292 : : PUNCT fnp-3684 3 1 11 11 NUM fnp-3684 3 2 january january PROPN fnp-3684 3 3 2022 2022 NUM fnp-3684 3 4 https://doi.org/10.17879/freeneuropathology-2022-3684 https://doi.org/10.17879/freeneuropathology-2022-3684 NOUN fnp-3684 3 5 keywords keyword NOUN fnp-3684 3 6 : : PUNCT fnp-3684 3 7 medulloblastoma medulloblastoma ADJ fnp-3684 3 8 , , PUNCT fnp-3684 3 9 cowden cowden PROPN fnp-3684 3 10 syndrome syndrome PROPN fnp-3684 3 11 , , PUNCT fnp-3684 3 12 pten pten VERB fnp-3684 3 13 abstract abstract PROPN fnp-3684 3 14 cowden cowden PROPN fnp-3684 3 15 syndrome syndrome PROPN fnp-3684 3 16 ( ( PUNCT fnp-3684 3 17 cs cs PROPN fnp-3684 3 18 ) ) PUNCT fnp-3684 3 19 is be AUX fnp-3684 3 20 an an DET fnp-3684 3 21 autosomal autosomal ADJ fnp-3684 3 22 dominant dominant ADJ fnp-3684 3 23 hamartoma hamartoma NOUN fnp-3684 3 24 and and CCONJ fnp-3684 3 25 tumor tumor NOUN fnp-3684 3 26 predisposition predisposition NOUN fnp-3684 3 27 syndrome syndrome NOUN fnp-3684 3 28 caused cause VERB fnp-3684 3 29 by by ADP fnp-3684 3 30 heterozygous heterozygous ADJ fnp-3684 3 31 pathogenic pathogenic ADJ fnp-3684 3 32 germline germline NOUN fnp-3684 3 33 variants variant NOUN fnp-3684 3 34 in in ADP fnp-3684 3 35 pten pten NOUN fnp-3684 3 36 in in ADP fnp-3684 3 37 most most ADV fnp-3684 3 38 affected affect VERB fnp-3684 3 39 individuals individual NOUN fnp-3684 3 40 . . PUNCT fnp-3684 4 1 major major ADJ fnp-3684 4 2 features feature NOUN fnp-3684 4 3 include include VERB fnp-3684 4 4 macrocrania macrocrania NOUN fnp-3684 4 5 , , PUNCT fnp-3684 4 6 multiple multiple ADJ fnp-3684 4 7 facial facial ADJ fnp-3684 4 8 tricholemmomas tricholemmoma NOUN fnp-3684 4 9 , , PUNCT fnp-3684 4 10 acral acral ADJ fnp-3684 4 11 and and CCONJ fnp-3684 4 12 oral oral ADJ fnp-3684 4 13 keratoses keratose NOUN fnp-3684 4 14 and and CCONJ fnp-3684 4 15 papillomas papilloma NOUN fnp-3684 4 16 , , PUNCT fnp-3684 4 17 as as ADV fnp-3684 4 18 well well ADV fnp-3684 4 19 as as ADP fnp-3684 4 20 mammary mammary ADJ fnp-3684 4 21 , , PUNCT fnp-3684 4 22 non non ADJ fnp-3684 4 23 - - ADJ fnp-3684 4 24 medullary medullary ADJ fnp-3684 4 25 thyroid thyroid NOUN fnp-3684 4 26 , , PUNCT fnp-3684 4 27 renal renal ADJ fnp-3684 4 28 , , PUNCT fnp-3684 4 29 and and CCONJ fnp-3684 4 30 endometrial endometrial ADJ fnp-3684 4 31 carcinomas carcinoma NOUN fnp-3684 4 32 . . PUNCT fnp-3684 5 1 lhermitte lhermitte NOUN fnp-3684 5 2 - - PUNCT fnp-3684 5 3 duclos duclo NOUN fnp-3684 5 4 disease disease NOUN fnp-3684 5 5 ( ( PUNCT fnp-3684 5 6 ldd ldd PROPN fnp-3684 5 7 ) ) PUNCT fnp-3684 5 8 , , PUNCT fnp-3684 5 9 or or CCONJ fnp-3684 5 10 dysplastic dysplastic ADJ fnp-3684 5 11 gangliocytoma gangliocytoma NOUN fnp-3684 5 12 of of ADP fnp-3684 5 13 the the DET fnp-3684 5 14 cerebellum cerebellum NOUN fnp-3684 5 15 , , PUNCT fnp-3684 5 16 is be AUX fnp-3684 5 17 the the DET fnp-3684 5 18 typical typical ADJ fnp-3684 5 19 brain brain NOUN fnp-3684 5 20 tumor tumor NOUN fnp-3684 5 21 associated associate VERB fnp-3684 5 22 with with ADP fnp-3684 5 23 cs cs PROPN fnp-3684 5 24 ; ; PUNCT fnp-3684 5 25 the the DET fnp-3684 5 26 lifetime lifetime NOUN fnp-3684 5 27 risk risk NOUN fnp-3684 5 28 for for ADP fnp-3684 5 29 ldd ldd PROPN fnp-3684 5 30 in in ADP fnp-3684 5 31 cs cs ADJ fnp-3684 5 32 patients patient NOUN fnp-3684 5 33 has have AUX fnp-3684 5 34 been be AUX fnp-3684 5 35 estimated estimate VERB fnp-3684 5 36 to to PART fnp-3684 5 37 be be AUX fnp-3684 5 38 as as ADV fnp-3684 5 39 high high ADJ fnp-3684 5 40 as as ADP fnp-3684 5 41 30 30 NUM fnp-3684 5 42 % % NOUN fnp-3684 5 43 . . PUNCT fnp-3684 6 1 in in ADP fnp-3684 6 2 contrast contrast NOUN fnp-3684 6 3 , , PUNCT fnp-3684 6 4 medulloblastoma medulloblastoma NOUN fnp-3684 6 5 is be AUX fnp-3684 6 6 much much ADV fnp-3684 6 7 rarer rare ADJ fnp-3684 6 8 in in ADP fnp-3684 6 9 cs cs PROPN fnp-3684 6 10 , , PUNCT fnp-3684 6 11 with with ADP fnp-3684 6 12 only only ADV fnp-3684 6 13 4 4 NUM fnp-3684 6 14 reported report VERB fnp-3684 6 15 cases case NOUN fnp-3684 6 16 in in ADP fnp-3684 6 17 the the DET fnp-3684 6 18 literature literature NOUN fnp-3684 6 19 . . PUNCT fnp-3684 7 1 we we PRON fnp-3684 7 2 report report VERB fnp-3684 7 3 a a DET fnp-3684 7 4 5th 5th ADJ fnp-3684 7 5 such such ADJ fnp-3684 7 6 patient patient NOUN fnp-3684 7 7 . . PUNCT fnp-3684 8 1 all all DET fnp-3684 8 2 5 5 NUM fnp-3684 8 3 patients patient NOUN fnp-3684 8 4 were be AUX fnp-3684 8 5 diagnosed diagnose VERB fnp-3684 8 6 between between ADP fnp-3684 8 7 1 1 NUM fnp-3684 8 8 and and CCONJ fnp-3684 8 9 2 2 NUM fnp-3684 8 10 years year NOUN fnp-3684 8 11 of of ADP fnp-3684 8 12 age age NOUN fnp-3684 8 13 and and CCONJ fnp-3684 8 14 not not PART fnp-3684 8 15 all all PRON fnp-3684 8 16 showed show VERB fnp-3684 8 17 the the DET fnp-3684 8 18 pathognomonic pathognomonic ADJ fnp-3684 8 19 clinical clinical ADJ fnp-3684 8 20 stigmata stigmata NOUN fnp-3684 8 21 of of ADP fnp-3684 8 22 cs cs PROPN fnp-3684 8 23 at at ADP fnp-3684 8 24 the the DET fnp-3684 8 25 time time NOUN fnp-3684 8 26 of of ADP fnp-3684 8 27 their their PRON fnp-3684 8 28 medulloblastoma medulloblastoma ADJ fnp-3684 8 29 diagnosis diagnosis NOUN fnp-3684 8 30 . . PUNCT fnp-3684 9 1 where where SCONJ fnp-3684 9 2 detailed detailed ADJ fnp-3684 9 3 information information NOUN fnp-3684 9 4 was be AUX fnp-3684 9 5 available available ADJ fnp-3684 9 6 , , PUNCT fnp-3684 9 7 the the DET fnp-3684 9 8 medulloblastoma medulloblastoma NOUN fnp-3684 9 9 was be AUX fnp-3684 9 10 of of ADP fnp-3684 9 11 the the DET fnp-3684 9 12 shh shh NOUN fnp-3684 9 13 - - NOUN fnp-3684 9 14 subtype subtype NOUN fnp-3684 9 15 , , PUNCT fnp-3684 9 16 in in ADP fnp-3684 9 17 keeping keep VERB fnp-3684 9 18 with with ADP fnp-3684 9 19 the the DET fnp-3684 9 20 observation observation NOUN fnp-3684 9 21 that that SCONJ fnp-3684 9 22 in in ADP fnp-3684 9 23 sporadic sporadic ADJ fnp-3684 9 24 medulloblastomas medulloblastoma NOUN fnp-3684 9 25 , , PUNCT fnp-3684 9 26 pten pten NOUN fnp-3684 9 27 - - PUNCT fnp-3684 9 28 alterations alteration NOUN fnp-3684 9 29 are be AUX fnp-3684 9 30 usually usually ADV fnp-3684 9 31 encountered encounter VERB fnp-3684 9 32 in in ADP fnp-3684 9 33 the the DET fnp-3684 9 34 shh shh NOUN fnp-3684 9 35 - - NOUN fnp-3684 9 36 subtype subtype NOUN fnp-3684 9 37 . . PUNCT fnp-3684 10 1 medulloblastomas medulloblastoma NOUN fnp-3684 10 2 can can AUX fnp-3684 10 3 be be AUX fnp-3684 10 4 associated associate VERB fnp-3684 10 5 with with ADP fnp-3684 10 6 several several ADJ fnp-3684 10 7 tumor tumor NOUN fnp-3684 10 8 - - PUNCT fnp-3684 10 9 predisposition predisposition NOUN fnp-3684 10 10 syndromes syndrome NOUN fnp-3684 10 11 and and CCONJ fnp-3684 10 12 of of ADP fnp-3684 10 13 the the DET fnp-3684 10 14 4 4 NUM fnp-3684 10 15 medulloblastoma medulloblastoma NOUN fnp-3684 10 16 subtypes subtype NOUN fnp-3684 10 17 , , PUNCT fnp-3684 10 18 shh shh NOUN fnp-3684 10 19 - - PUNCT fnp-3684 10 20 medulloblastomas medulloblastoma NOUN fnp-3684 10 21 in in ADP fnp-3684 10 22 children child NOUN fnp-3684 10 23 have have VERB fnp-3684 10 24 the the DET fnp-3684 10 25 highest high ADJ fnp-3684 10 26 prevalence prevalence NOUN fnp-3684 10 27 of of ADP fnp-3684 10 28 predisposing predispose VERB fnp-3684 10 29 germline germline NOUN fnp-3684 10 30 variants variant NOUN fnp-3684 10 31 ( ( PUNCT fnp-3684 10 32 approx approx PROPN fnp-3684 10 33 . . PUNCT fnp-3684 11 1 40 40 NUM fnp-3684 11 2 % % NOUN fnp-3684 11 3 ) ) PUNCT fnp-3684 11 4 . . PUNCT fnp-3684 12 1 cs cs PROPN fnp-3684 12 2 should should AUX fnp-3684 12 3 be be AUX fnp-3684 12 4 added add VERB fnp-3684 12 5 to to ADP fnp-3684 12 6 the the DET fnp-3684 12 7 list list NOUN fnp-3684 12 8 of of ADP fnp-3684 12 9 shh shh NOUN fnp-3684 12 10 - - PUNCT fnp-3684 12 11 medulloblastoma medulloblastoma ADV fnp-3684 12 12 - - PUNCT fnp-3684 12 13 associated associate VERB fnp-3684 12 14 syndromes syndrome NOUN fnp-3684 12 15 . . PUNCT fnp-3684 13 1 germline germline VERB fnp-3684 13 2 analysis analysis NOUN fnp-3684 13 3 of of ADP fnp-3684 13 4 pten pten NOUN fnp-3684 13 5 should should AUX fnp-3684 13 6 be be AUX fnp-3684 13 7 performed perform VERB fnp-3684 13 8 in in ADP fnp-3684 13 9 infants infant NOUN fnp-3684 13 10 with with ADP fnp-3684 13 11 shh shh NOUN fnp-3684 13 12 - - PUNCT fnp-3684 13 13 medulloblastomas medulloblastoma NOUN fnp-3684 13 14 , , PUNCT fnp-3684 13 15 regardless regardless ADV fnp-3684 13 16 of of ADP fnp-3684 13 17 their their PRON fnp-3684 13 18 clinical clinical ADJ fnp-3684 13 19 phenotype phenotype NOUN fnp-3684 13 20 , , PUNCT fnp-3684 13 21 especially especially ADV fnp-3684 13 22 if if SCONJ fnp-3684 13 23 they they PRON fnp-3684 13 24 do do AUX fnp-3684 13 25 not not PART fnp-3684 13 26 carry carry VERB fnp-3684 13 27 pathogenic pathogenic ADJ fnp-3684 13 28 germline germline NOUN fnp-3684 13 29 variants variant NOUN fnp-3684 13 30 in in ADP fnp-3684 13 31 ptch1 ptch1 PROPN fnp-3684 13 32 or or CCONJ fnp-3684 13 33 sufu sufu PROPN fnp-3684 13 34 , , PUNCT fnp-3684 13 35 the the DET fnp-3684 13 36 most most ADV fnp-3684 13 37 commonly commonly ADV fnp-3684 13 38 altered alter VERB fnp-3684 13 39 predisposing predispose VERB fnp-3684 13 40 genes gene NOUN fnp-3684 13 41 in in ADP fnp-3684 13 42 this this DET fnp-3684 13 43 age age NOUN fnp-3684 13 44 - - PUNCT fnp-3684 13 45 group group NOUN fnp-3684 13 46 . . PUNCT fnp-3684 14 1 in in ADP fnp-3684 14 2 addition addition NOUN fnp-3684 14 3 , , PUNCT fnp-3684 14 4 these these DET fnp-3684 14 5 cases case NOUN fnp-3684 14 6 show show VERB fnp-3684 14 7 that that SCONJ fnp-3684 14 8 cs cs PROPN fnp-3684 14 9 has have VERB fnp-3684 14 10 a a DET fnp-3684 14 11 biphasic biphasic ADJ fnp-3684 14 12 brain brain NOUN fnp-3684 14 13 tumor tumor NOUN fnp-3684 14 14 distribution distribution NOUN fnp-3684 14 15 , , PUNCT fnp-3684 14 16 both both CCONJ fnp-3684 14 17 in in ADP fnp-3684 14 18 regards regard NOUN fnp-3684 14 19 to to ADP fnp-3684 14 20 the the DET fnp-3684 14 21 age age NOUN fnp-3684 14 22 of of ADP fnp-3684 14 23 onset onset NOUN fnp-3684 14 24 and and CCONJ fnp-3684 14 25 the the DET fnp-3684 14 26 tumor tumor NOUN fnp-3684 14 27 type type NOUN fnp-3684 14 28 : : PUNCT fnp-3684 14 29 a a DET fnp-3684 14 30 small small ADJ fnp-3684 14 31 number number NOUN fnp-3684 14 32 of of ADP fnp-3684 14 33 cs cs PROPN fnp-3684 14 34 patients patient NOUN fnp-3684 14 35 develop develop VERB fnp-3684 14 36 a a DET fnp-3684 14 37 medulloblastoma medulloblastoma NOUN fnp-3684 14 38 in in ADP fnp-3684 14 39 infancy infancy NOUN fnp-3684 14 40 while while SCONJ fnp-3684 14 41 many many ADJ fnp-3684 14 42 more more ADV fnp-3684 14 43 develop develop VERB fnp-3684 14 44 ldd ldd PROPN fnp-3684 14 45 in in ADP fnp-3684 14 46 adulthood adulthood NOUN fnp-3684 14 47 . . PUNCT fnp-3684 15 1 case case NOUN fnp-3684 15 2 history history NOUN fnp-3684 15 3 the the DET fnp-3684 15 4 patient patient NOUN fnp-3684 15 5 was be AUX fnp-3684 15 6 born bear VERB fnp-3684 15 7 at at ADP fnp-3684 15 8 term term NOUN fnp-3684 15 9 after after ADP fnp-3684 15 10 an an DET fnp-3684 15 11 uneventful uneventful ADJ fnp-3684 15 12 pregnancy pregnancy NOUN fnp-3684 15 13 ; ; PUNCT fnp-3684 15 14 however however ADV fnp-3684 15 15 , , PUNCT fnp-3684 15 16 she she PRON fnp-3684 15 17 was be AUX fnp-3684 15 18 noted note VERB fnp-3684 15 19 to to PART fnp-3684 15 20 have have AUX fnp-3684 15 21 pronounced pronounce VERB fnp-3684 15 22 frontal frontal ADJ fnp-3684 15 23 bossing bossing NOUN fnp-3684 15 24 and and CCONJ fnp-3684 15 25 macrocrania macrocrania NOUN fnp-3684 15 26 , , PUNCT fnp-3684 15 27 ( ( PUNCT fnp-3684 15 28 head head NOUN fnp-3684 15 29 circumference circumference NOUN fnp-3684 15 30 > > X fnp-3684 15 31 98th 98th ADJ fnp-3684 15 32 percentile percentile NOUN fnp-3684 15 33 ) ) PUNCT fnp-3684 15 34 . . PUNCT fnp-3684 16 1 she she PRON fnp-3684 16 2 presented present VERB fnp-3684 16 3 at at ADP fnp-3684 16 4 age age NOUN fnp-3684 16 5 15 15 NUM fnp-3684 16 6 months month NOUN fnp-3684 16 7 because because SCONJ fnp-3684 16 8 of of ADP fnp-3684 16 9 rapidly rapidly ADV fnp-3684 16 10 increasing increase VERB fnp-3684 16 11 head head NOUN fnp-3684 16 12 circumference circumference NOUN fnp-3684 16 13 . . PUNCT fnp-3684 17 1 mri mri NOUN fnp-3684 17 2 showed show VERB fnp-3684 17 3 an an DET fnp-3684 17 4 extra extra ADJ fnp-3684 17 5 - - ADJ fnp-3684 17 6 axial axial ADJ fnp-3684 17 7 posterior posterior ADJ fnp-3684 17 8 fossa fossa NOUN fnp-3684 17 9 mass mass NOUN fnp-3684 17 10 within within ADP fnp-3684 17 11 the the DET fnp-3684 17 12 cisterna cisterna PROPN fnp-3684 17 13 magna magna PROPN fnp-3684 17 14 , , PUNCT fnp-3684 17 15 measuring measure VERB fnp-3684 17 16 5.3 5.3 NUM fnp-3684 17 17 x x SYM fnp-3684 17 18 4.4 4.4 NUM fnp-3684 17 19 x x SYM fnp-3684 17 20 3.2 3.2 NUM fnp-3684 17 21 cm cm NOUN fnp-3684 17 22 . . PUNCT fnp-3684 18 1 the the DET fnp-3684 18 2 tumor tumor NOUN fnp-3684 18 3 was be AUX fnp-3684 18 4 resected resect VERB fnp-3684 18 5 ; ; PUNCT fnp-3684 18 6 post post ADJ fnp-3684 18 7 - - ADJ fnp-3684 18 8 operative operative ADJ fnp-3684 18 9 mri mri NOUN fnp-3684 18 10 confirmed confirm VERB fnp-3684 18 11 gross gross ADJ fnp-3684 18 12 total total ADJ fnp-3684 18 13 resection resection NOUN fnp-3684 18 14 . . PUNCT fnp-3684 19 1 histologically histologically ADV fnp-3684 19 2 , , PUNCT fnp-3684 19 3 it it PRON fnp-3684 19 4 was be AUX fnp-3684 19 5 a a DET fnp-3684 19 6 medulloblastoma medulloblastoma NOUN fnp-3684 19 7 with with ADP fnp-3684 19 8 extensive extensive ADJ fnp-3684 19 9 nodularity nodularity NOUN fnp-3684 19 10 ( ( PUNCT fnp-3684 19 11 mben mben PROPN fnp-3684 19 12 ) ) PUNCT fnp-3684 19 13 . . PUNCT fnp-3684 20 1 she she PRON fnp-3684 20 2 was be AUX fnp-3684 20 3 treated treat VERB fnp-3684 20 4 according accord VERB fnp-3684 20 5 to to ADP fnp-3684 20 6 the the DET fnp-3684 20 7 ccg-99703 ccg-99703 NOUN fnp-3684 20 8 protocol protocol NOUN fnp-3684 20 9 , , PUNCT fnp-3684 20 10 which which PRON fnp-3684 20 11 consists consist VERB fnp-3684 20 12 of of ADP fnp-3684 20 13 3 3 NUM fnp-3684 20 14 cycles cycle NOUN fnp-3684 20 15 of of ADP fnp-3684 20 16 induction induction NOUN fnp-3684 20 17 chemotherapy chemotherapy NOUN fnp-3684 20 18 followed follow VERB fnp-3684 20 19 by by ADP fnp-3684 20 20 3 3 NUM fnp-3684 20 21 cycles cycle NOUN fnp-3684 20 22 of of ADP fnp-3684 20 23 marrow marrow NOUN fnp-3684 20 24 - - PUNCT fnp-3684 20 25 ablative ablative ADJ fnp-3684 20 26 consolidation consolidation NOUN fnp-3684 20 27 chemotherapy chemotherapy NOUN fnp-3684 20 28 with with ADP fnp-3684 20 29 autologous autologous ADJ fnp-3684 20 30 stem stem NOUN fnp-3684 20 31 - - PUNCT fnp-3684 20 32 cell cell NOUN fnp-3684 20 33 rescue rescue NOUN fnp-3684 21 1 [ [ X fnp-3684 21 2 cohen cohen X fnp-3684 21 3 et et PROPN fnp-3684 21 4 al al PROPN fnp-3684 21 5 . . PROPN fnp-3684 21 6 2015 2015 NUM fnp-3684 21 7 ] ] PUNCT fnp-3684 21 8 ; ; PUNCT fnp-3684 21 9 however however ADV fnp-3684 21 10 , , PUNCT fnp-3684 21 11 she she PRON fnp-3684 21 12 only only ADV fnp-3684 21 13 received receive VERB fnp-3684 21 14 2 2 NUM fnp-3684 21 15 of of ADP fnp-3684 21 16 the the DET fnp-3684 21 17 latter latter ADJ fnp-3684 21 18 due due ADP fnp-3684 21 19 to to ADP fnp-3684 21 20 hematological hematological ADJ fnp-3684 21 21 toxicity toxicity NOUN fnp-3684 21 22 . . PUNCT fnp-3684 22 1 during during ADP fnp-3684 22 2 follow follow NOUN fnp-3684 22 3 - - PUNCT fnp-3684 22 4 up up NOUN fnp-3684 22 5 , , PUNCT fnp-3684 22 6 some some DET fnp-3684 22 7 keratotic keratotic ADJ fnp-3684 22 8 papules papule NOUN fnp-3684 22 9 on on ADP fnp-3684 22 10 the the DET fnp-3684 22 11 fingers finger NOUN fnp-3684 22 12 and and CCONJ fnp-3684 22 13 buttocks buttock NOUN fnp-3684 22 14 were be AUX fnp-3684 22 15 noted note VERB fnp-3684 22 16 and and CCONJ fnp-3684 22 17 therefore therefore ADV fnp-3684 22 18 gorlin gorlin PROPN fnp-3684 22 19 syndrome syndrome PROPN fnp-3684 22 20 ( ( PUNCT fnp-3684 22 21 nevoid nevoid PROPN fnp-3684 22 22 basal basal PROPN fnp-3684 22 23 cell cell NOUN fnp-3684 22 24 carcinoma carcinoma NOUN fnp-3684 22 25 syndrome syndrome NOUN fnp-3684 22 26 ; ; PUNCT fnp-3684 22 27 online online ADJ fnp-3684 22 28 mendelian mendelian ADJ fnp-3684 22 29 inheritance inheritance NOUN fnp-3684 22 30 in in ADP fnp-3684 22 31 man man NOUN fnp-3684 22 32 ( ( PUNCT fnp-3684 22 33 omim omim PROPN fnp-3684 22 34 ) ) PUNCT fnp-3684 22 35 # # SYM fnp-3684 22 36 109400 109400 NUM fnp-3684 22 37 ) ) PUNCT fnp-3684 22 38 was be AUX fnp-3684 22 39 suspected suspect VERB fnp-3684 22 40 clinically clinically ADV fnp-3684 22 41 . . PUNCT fnp-3684 23 1 some some PRON fnp-3684 23 2 of of ADP fnp-3684 23 3 these these DET fnp-3684 23 4 cutaneous cutaneous ADJ fnp-3684 23 5 lesions lesion NOUN fnp-3684 23 6 were be AUX fnp-3684 23 7 biopsied biopsie VERB fnp-3684 23 8 but but CCONJ fnp-3684 23 9 consisted consist VERB fnp-3684 23 10 of of ADP fnp-3684 23 11 non non ADJ fnp-3684 23 12 - - ADJ fnp-3684 23 13 specific specific ADJ fnp-3684 23 14 keratoses keratose NOUN fnp-3684 23 15 or or CCONJ fnp-3684 23 16 warts wart NOUN fnp-3684 23 17 ; ; PUNCT fnp-3684 23 18 there there PRON fnp-3684 23 19 were be VERB fnp-3684 23 20 no no DET fnp-3684 23 21 basal basal ADJ fnp-3684 23 22 carcinomas carcinoma NOUN fnp-3684 23 23 . . PUNCT fnp-3684 24 1 initial initial ADJ fnp-3684 24 2 germline germline VERB fnp-3684 24 3 genetic genetic ADJ fnp-3684 24 4 testing testing NOUN fnp-3684 24 5 at at ADP fnp-3684 24 6 age age NOUN fnp-3684 24 7 2 2 NUM fnp-3684 24 8 consisted consist VERB fnp-3684 24 9 of of ADP fnp-3684 24 10 deletion deletion NOUN fnp-3684 24 11 analysis analysis NOUN fnp-3684 24 12 and and CCONJ fnp-3684 24 13 sanger sanger PROPN fnp-3684 24 14 sequencing sequencing NOUN fnp-3684 24 15 of of ADP fnp-3684 24 16 ptch1 ptch1 PROPN fnp-3684 24 17 , , PUNCT fnp-3684 24 18 which which PRON fnp-3684 24 19 were be AUX fnp-3684 24 20 negative negative ADJ fnp-3684 24 21 . . PUNCT fnp-3684 25 1 sanger sanger PROPN fnp-3684 25 2 sequencing sequencing NOUN fnp-3684 25 3 of of ADP fnp-3684 25 4 sufu sufu NOUN fnp-3684 25 5 was be AUX fnp-3684 25 6 done do VERB fnp-3684 25 7 at at ADP fnp-3684 25 8 age age NOUN fnp-3684 25 9 5 5 NUM fnp-3684 25 10 and and CCONJ fnp-3684 25 11 was be AUX fnp-3684 25 12 negative negative ADJ fnp-3684 25 13 . . PUNCT fnp-3684 26 1 at at ADP fnp-3684 26 2 age age NOUN fnp-3684 26 3 8 8 NUM fnp-3684 26 4 , , PUNCT fnp-3684 26 5 a a DET fnp-3684 26 6 firm firm ADJ fnp-3684 26 7 papule papule NOUN fnp-3684 26 8 was be AUX fnp-3684 26 9 noted note VERB fnp-3684 26 10 on on ADP fnp-3684 26 11 the the DET fnp-3684 26 12 neck neck NOUN fnp-3684 26 13 ; ; PUNCT fnp-3684 26 14 histologically histologically ADV fnp-3684 26 15 , , PUNCT fnp-3684 26 16 it it PRON fnp-3684 26 17 was be AUX fnp-3684 26 18 a a DET fnp-3684 26 19 sclerotic sclerotic ADJ fnp-3684 26 20 fibroma fibroma NOUN fnp-3684 26 21 . . PUNCT fnp-3684 27 1 ( ( PUNCT fnp-3684 27 2 a a DET fnp-3684 27 3 similar similar ADJ fnp-3684 27 4 lesion lesion NOUN fnp-3684 27 5 was be AUX fnp-3684 27 6 also also ADV fnp-3684 27 7 noted note VERB fnp-3684 27 8 on on ADP fnp-3684 27 9 the the DET fnp-3684 27 10 left left ADJ fnp-3684 27 11 thigh thigh NOUN fnp-3684 27 12 , , PUNCT fnp-3684 27 13 but but CCONJ fnp-3684 27 14 not not PART fnp-3684 27 15 excised excise VERB fnp-3684 27 16 . . PUNCT fnp-3684 27 17 ) ) PUNCT fnp-3684 28 1 at at ADP fnp-3684 28 2 age age NOUN fnp-3684 28 3 9 9 NUM fnp-3684 28 4 , , PUNCT fnp-3684 28 5 four four NUM fnp-3684 28 6 palmar palmar NOUN fnp-3684 28 7 pits pit NOUN fnp-3684 28 8 were be AUX fnp-3684 28 9 noted note VERB fnp-3684 28 10 on on ADP fnp-3684 28 11 the the DET fnp-3684 28 12 right right ADJ fnp-3684 28 13 hand hand NOUN fnp-3684 28 14 . . PUNCT fnp-3684 29 1 although although SCONJ fnp-3684 29 2 the the DET fnp-3684 29 3 combination combination NOUN fnp-3684 29 4 of of ADP fnp-3684 29 5 palmar palmar NOUN fnp-3684 29 6 pits pit NOUN fnp-3684 29 7 , , PUNCT fnp-3684 29 8 mben mben NOUN fnp-3684 29 9 , , PUNCT fnp-3684 29 10 and and CCONJ fnp-3684 29 11 macrocrania macrocrania NOUN fnp-3684 29 12 was be AUX fnp-3684 29 13 suggestive suggestive ADJ fnp-3684 29 14 of of ADP fnp-3684 29 15 gorlin gorlin PROPN fnp-3684 29 16 syndrome syndrome PROPN fnp-3684 29 17 , , PUNCT fnp-3684 29 18 sclerotic sclerotic ADJ fnp-3684 29 19 fibroma fibroma NOUN fnp-3684 29 20 has have AUX fnp-3684 29 21 been be AUX fnp-3684 29 22 associated associate VERB fnp-3684 29 23 with with ADP fnp-3684 29 24 cowden cowden PROPN fnp-3684 29 25 syndrome syndrome PROPN fnp-3684 29 26 ( ( PUNCT fnp-3684 29 27 cs cs PROPN fnp-3684 29 28 ; ; PUNCT fnp-3684 29 29 omim omim PROPN fnp-3684 29 30 # # SYM fnp-3684 29 31 158350 158350 NUM fnp-3684 29 32 ) ) PUNCT fnp-3684 30 1 [ [ X fnp-3684 30 2 kieselova kieselova X fnp-3684 30 3 et et PROPN fnp-3684 30 4 al al PROPN fnp-3684 30 5 . . PROPN fnp-3684 30 6 2017 2017 NUM fnp-3684 30 7 ] ] PUNCT fnp-3684 30 8 . . PUNCT fnp-3684 31 1 therefore therefore ADV fnp-3684 31 2 , , PUNCT fnp-3684 31 3 next next ADJ fnp-3684 31 4 - - PUNCT fnp-3684 31 5 generation generation NOUN fnp-3684 31 6 germline germline NOUN fnp-3684 31 7 sequencing sequencing NOUN fnp-3684 31 8 of of ADP fnp-3684 31 9 ptch1 ptch1 PROPN fnp-3684 31 10 , , PUNCT fnp-3684 31 11 ptch2 ptch2 PROPN fnp-3684 31 12 , , PUNCT fnp-3684 31 13 sufu sufu NOUN fnp-3684 31 14 , , PUNCT fnp-3684 31 15 and and CCONJ fnp-3684 31 16 pten pten NOUN fnp-3684 31 17 was be AUX fnp-3684 31 18 performed perform VERB fnp-3684 31 19 . . PUNCT fnp-3684 32 1 a a DET fnp-3684 32 2 previously previously ADV fnp-3684 32 3 reported report VERB fnp-3684 32 4 pathogenic pathogenic ADJ fnp-3684 32 5 variant variant NOUN fnp-3684 32 6 in in ADP fnp-3684 32 7 pten pten NOUN fnp-3684 32 8 , , PUNCT fnp-3684 32 9 c.388c c.388c PROPN fnp-3684 32 10 > > PROPN fnp-3684 32 11 t t PROPN fnp-3684 32 12 , , PUNCT fnp-3684 32 13 p.r130 p.r130 NOUN fnp-3684 32 14 * * PUNCT fnp-3684 32 15 ( ( PUNCT fnp-3684 32 16 cosv64288463 cosv64288463 PROPN fnp-3684 32 17 ) ) PUNCT fnp-3684 32 18 , , PUNCT fnp-3684 32 19 was be AUX fnp-3684 32 20 identified identify VERB fnp-3684 32 21 . . PUNCT fnp-3684 33 1 no no DET fnp-3684 33 2 variants variant NOUN fnp-3684 33 3 were be AUX fnp-3684 33 4 found find VERB fnp-3684 33 5 in in ADP fnp-3684 33 6 the the DET fnp-3684 33 7 other other ADJ fnp-3684 33 8 genes gene NOUN fnp-3684 33 9 . . PUNCT fnp-3684 34 1 parental parental ADJ fnp-3684 34 2 studies study NOUN fnp-3684 34 3 were be AUX fnp-3684 34 4 negative negative ADJ fnp-3684 34 5 , , PUNCT fnp-3684 34 6 suggesting suggest VERB fnp-3684 34 7 most most ADV fnp-3684 34 8 likely likely ADJ fnp-3684 34 9 a a DET fnp-3684 34 10 de de X fnp-3684 34 11 novo novo NOUN fnp-3684 34 12 mutation mutation NOUN fnp-3684 34 13 , , PUNCT fnp-3684 34 14 although although SCONJ fnp-3684 34 15 gonadal gonadal ADJ fnp-3684 34 16 mosaicism mosaicism NOUN fnp-3684 34 17 in in ADP fnp-3684 34 18 one one NUM fnp-3684 34 19 of of ADP fnp-3684 34 20 the the DET fnp-3684 34 21 parents parent NOUN fnp-3684 34 22 can can AUX fnp-3684 34 23 not not PART fnp-3684 34 24 be be AUX fnp-3684 34 25 ruled rule VERB fnp-3684 34 26 out out ADP fnp-3684 34 27 . . PUNCT fnp-3684 35 1 at at ADP fnp-3684 35 2 age age NOUN fnp-3684 35 3 10 10 NUM fnp-3684 35 4 , , PUNCT fnp-3684 35 5 a a DET fnp-3684 35 6 posterior posterior ADJ fnp-3684 35 7 fossa fossa ADJ fnp-3684 35 8 dural dural ADJ fnp-3684 35 9 arterio arterio NOUN fnp-3684 35 10 - - PUNCT fnp-3684 35 11 venous venous ADJ fnp-3684 35 12 fistula fistula NOUN fnp-3684 35 13 ( ( PUNCT fnp-3684 35 14 davf davf NOUN fnp-3684 35 15 ) ) PUNCT fnp-3684 35 16 was be AUX fnp-3684 35 17 suspected suspect VERB fnp-3684 35 18 on on ADP fnp-3684 35 19 a a DET fnp-3684 35 20 routine routine ADJ fnp-3684 35 21 follow follow VERB fnp-3684 35 22 - - PUNCT fnp-3684 35 23 up up NOUN fnp-3684 35 24 mri mri NOUN fnp-3684 35 25 and and CCONJ fnp-3684 35 26 confirmed confirm VERB fnp-3684 35 27 by by ADP fnp-3684 35 28 cerebral cerebral ADJ fnp-3684 35 29 angiogram angiogram NOUN fnp-3684 35 30 to to PART fnp-3684 35 31 be be AUX fnp-3684 35 32 a a DET fnp-3684 35 33 borden borden NOUN fnp-3684 35 34 type type NOUN fnp-3684 35 35 1 1 NUM fnp-3684 35 36 davf davf NOUN fnp-3684 35 37 draining drain VERB fnp-3684 35 38 into into ADP fnp-3684 35 39 an an DET fnp-3684 35 40 ectopic ectopic ADJ fnp-3684 35 41 pouch pouch NOUN fnp-3684 35 42 of of ADP fnp-3684 35 43 the the DET fnp-3684 35 44 right right ADJ fnp-3684 35 45 transverse transverse NOUN fnp-3684 35 46 sinus sinus NOUN fnp-3684 35 47 ; ; PUNCT fnp-3684 35 48 it it PRON fnp-3684 35 49 was be AUX fnp-3684 35 50 fed feed VERB fnp-3684 35 51 by by ADP fnp-3684 35 52 branches branch NOUN fnp-3684 35 53 of of ADP fnp-3684 35 54 the the DET fnp-3684 35 55 right right NOUN fnp-3684 35 56 and and CCONJ fnp-3684 35 57 left leave VERB fnp-3684 35 58 external external ADJ fnp-3684 35 59 carotid carotid NOUN fnp-3684 35 60 arteries artery NOUN fnp-3684 35 61 and and CCONJ fnp-3684 35 62 the the DET fnp-3684 35 63 right right ADJ fnp-3684 35 64 posterior posterior ADJ fnp-3684 35 65 cerebral cerebral ADJ fnp-3684 35 66 artery artery NOUN fnp-3684 35 67 . . PUNCT fnp-3684 36 1 although although SCONJ fnp-3684 36 2 hemorrhage hemorrhage NOUN fnp-3684 36 3 from from ADP fnp-3684 36 4 intracranial intracranial ADJ fnp-3684 36 5 avfs avfs NOUN fnp-3684 36 6 has have AUX fnp-3684 36 7 been be AUX fnp-3684 36 8 reported report VERB fnp-3684 36 9 in in ADP fnp-3684 36 10 patients patient NOUN fnp-3684 36 11 with with ADP fnp-3684 36 12 cs cs PROPN fnp-3684 36 13 [ [ X fnp-3684 36 14 prats prat NOUN fnp-3684 36 15 - - PUNCT fnp-3684 36 16 sánchez sánchez NOUN fnp-3684 36 17 et et PROPN fnp-3684 36 18 al al PROPN fnp-3684 36 19 . . PROPN fnp-3684 36 20 2016 2016 NUM fnp-3684 36 21 ] ] PUNCT fnp-3684 36 22 , , PUNCT fnp-3684 36 23 borden borden PROPN fnp-3684 36 24 type type NOUN fnp-3684 36 25 1 1 NUM fnp-3684 36 26 davfs davfs NOUN fnp-3684 36 27 have have VERB fnp-3684 36 28 a a DET fnp-3684 36 29 very very ADV fnp-3684 36 30 low low ADJ fnp-3684 36 31 risk risk NOUN fnp-3684 36 32 of of ADP fnp-3684 36 33 hemorrhage hemorrhage NOUN fnp-3684 37 1 [ [ X fnp-3684 37 2 gandhi gandhi PROPN fnp-3684 37 3 et et PROPN fnp-3684 37 4 al al PROPN fnp-3684 37 5 . . PROPN fnp-3684 37 6 2012 2012 NUM fnp-3684 37 7 ] ] PUNCT fnp-3684 37 8 and and CCONJ fnp-3684 37 9 the the DET fnp-3684 37 10 lesion lesion NOUN fnp-3684 37 11 was be AUX fnp-3684 37 12 completely completely ADV fnp-3684 37 13 asymptomatic asymptomatic ADJ fnp-3684 37 14 . . PUNCT fnp-3684 38 1 it it PRON fnp-3684 38 2 was be AUX fnp-3684 38 3 therefore therefore ADV fnp-3684 38 4 not not PART fnp-3684 38 5 treated treat VERB fnp-3684 38 6 . . PUNCT fnp-3684 39 1 it it PRON fnp-3684 39 2 was be AUX fnp-3684 39 3 no no ADV fnp-3684 39 4 longer long ADV fnp-3684 39 5 seen see VERB fnp-3684 39 6 on on ADP fnp-3684 39 7 repeat repeat NOUN fnp-3684 39 8 imaging imaging NOUN fnp-3684 39 9 a a DET fnp-3684 39 10 year year NOUN fnp-3684 39 11 later later ADV fnp-3684 39 12 , , PUNCT fnp-3684 39 13 suggesting suggest VERB fnp-3684 39 14 spontaneous spontaneous ADJ fnp-3684 39 15 involution involution NOUN fnp-3684 39 16 - - PUNCT fnp-3684 39 17 resolution resolution NOUN fnp-3684 39 18 . . PUNCT fnp-3684 40 1 at at ADP fnp-3684 40 2 age age NOUN fnp-3684 40 3 12 12 NUM fnp-3684 40 4 , , PUNCT fnp-3684 40 5 multiple multiple ADJ fnp-3684 40 6 thyroid thyroid NOUN fnp-3684 40 7 nodules nodule NOUN fnp-3684 40 8 were be AUX fnp-3684 40 9 noted note VERB fnp-3684 40 10 bilaterally bilaterally ADV fnp-3684 40 11 on on ADP fnp-3684 40 12 ultrasound ultrasound NOUN fnp-3684 40 13 ; ; PUNCT fnp-3684 40 14 fine fine ADJ fnp-3684 40 15 needle needle NOUN fnp-3684 40 16 aspiration aspiration NOUN fnp-3684 40 17 cytology cytology NOUN fnp-3684 40 18 was be AUX fnp-3684 40 19 consistent consistent ADJ fnp-3684 40 20 with with ADP fnp-3684 40 21 benign benign ADJ fnp-3684 40 22 follicular follicular ADJ fnp-3684 40 23 nodules nodule NOUN fnp-3684 40 24 . . PUNCT fnp-3684 41 1 now now ADV fnp-3684 41 2 age age NOUN fnp-3684 41 3 13 13 NUM fnp-3684 41 4 ( ( PUNCT fnp-3684 41 5 i.e. i.e. X fnp-3684 41 6 , , PUNCT fnp-3684 41 7 12 12 NUM fnp-3684 41 8 years year NOUN fnp-3684 41 9 post post ADJ fnp-3684 41 10 - - NOUN fnp-3684 41 11 diagnosis diagnosis NOUN fnp-3684 41 12 ) ) PUNCT fnp-3684 41 13 , , PUNCT fnp-3684 41 14 the the DET fnp-3684 41 15 patient patient NOUN fnp-3684 41 16 is be AUX fnp-3684 41 17 alive alive ADJ fnp-3684 41 18 and and CCONJ fnp-3684 41 19 well well ADV fnp-3684 41 20 without without ADP fnp-3684 41 21 evidence evidence NOUN fnp-3684 41 22 of of ADP fnp-3684 41 23 recurrent recurrent ADJ fnp-3684 41 24 medulloblastoma medulloblastoma NOUN fnp-3684 41 25 . . PUNCT fnp-3684 42 1 she she PRON fnp-3684 42 2 does do AUX fnp-3684 42 3 not not PART fnp-3684 42 4 have have VERB fnp-3684 42 5 facial facial ADJ fnp-3684 42 6 or or CCONJ fnp-3684 42 7 oral oral ADJ fnp-3684 42 8 lesions lesion NOUN fnp-3684 42 9 . . PUNCT fnp-3684 43 1 figure figure NOUN fnp-3684 43 2 1 1 NUM fnp-3684 43 3 . . PUNCT fnp-3684 43 4 representative representative ADJ fnp-3684 43 5 images image NOUN fnp-3684 43 6 of of ADP fnp-3684 43 7 the the DET fnp-3684 43 8 cerebellar cerebellar ADJ fnp-3684 43 9 tumor tumor PROPN fnp-3684 43 10 ’s ’s PART fnp-3684 43 11 histology histology NOUN fnp-3684 43 12 and and CCONJ fnp-3684 43 13 immunophenotype immunophenotype NOUN fnp-3684 43 14 . . PUNCT fnp-3684 44 1 individual individual ADJ fnp-3684 44 2 images image NOUN fnp-3684 44 3 are be AUX fnp-3684 44 4 labelled label VERB fnp-3684 44 5 with with ADP fnp-3684 44 6 the the DET fnp-3684 44 7 respective respective ADJ fnp-3684 44 8 stain stain NOUN fnp-3684 44 9 . . PUNCT fnp-3684 45 1 on on ADP fnp-3684 45 2 low low ADJ fnp-3684 45 3 power power NOUN fnp-3684 45 4 , , PUNCT fnp-3684 45 5 the the DET fnp-3684 45 6 tumor tumor NOUN fnp-3684 45 7 is be AUX fnp-3684 45 8 biphasic biphasic ADJ fnp-3684 45 9 and and CCONJ fnp-3684 45 10 distinctly distinctly ADV fnp-3684 45 11 nodular nodular ADJ fnp-3684 45 12 . . PUNCT fnp-3684 46 1 most most ADJ fnp-3684 46 2 of of ADP fnp-3684 46 3 the the DET fnp-3684 46 4 tumor tumor NOUN fnp-3684 46 5 is be AUX fnp-3684 46 6 made make VERB fnp-3684 46 7 up up ADP fnp-3684 46 8 of of ADP fnp-3684 46 9 neurocytic neurocytic ADJ fnp-3684 46 10 to to ADP fnp-3684 46 11 gangliocytic gangliocytic ADJ fnp-3684 46 12 cells cell NOUN fnp-3684 46 13 ( ( PUNCT fnp-3684 46 14 high high ADJ fnp-3684 46 15 power power NOUN fnp-3684 46 16 inset inset NOUN fnp-3684 46 17 ) ) PUNCT fnp-3684 46 18 that that PRON fnp-3684 46 19 are be AUX fnp-3684 46 20 strongly strongly ADV fnp-3684 46 21 neun neun X fnp-3684 46 22 immunoreactive immunoreactive ADJ fnp-3684 46 23 and and CCONJ fnp-3684 46 24 embedded embed VERB fnp-3684 46 25 in in ADP fnp-3684 46 26 a a DET fnp-3684 46 27 synaptophysin synaptophysin NOUN fnp-3684 46 28 - - PUNCT fnp-3684 46 29 positive positive ADJ fnp-3684 46 30 neuropil neuropil NOUN fnp-3684 46 31 - - PUNCT fnp-3684 46 32 like like ADJ fnp-3684 46 33 matrix matrix NOUN fnp-3684 46 34 that that PRON fnp-3684 46 35 contains contain VERB fnp-3684 46 36 bundles bundle NOUN fnp-3684 46 37 of of ADP fnp-3684 46 38 neurites neurite NOUN fnp-3684 46 39 . . PUNCT fnp-3684 47 1 the the DET fnp-3684 47 2 highly highly ADV fnp-3684 47 3 cellular cellular ADJ fnp-3684 47 4 desmoplastic desmoplastic ADJ fnp-3684 47 5 component component NOUN fnp-3684 47 6 shows show VERB fnp-3684 47 7 some some DET fnp-3684 47 8 staining stain VERB fnp-3684 47 9 for for ADP fnp-3684 47 10 gfap gfap NOUN fnp-3684 47 11 and and CCONJ fnp-3684 47 12 is be AUX fnp-3684 47 13 strongly strongly ADV fnp-3684 47 14 positive positive ADJ fnp-3684 47 15 for for ADP fnp-3684 47 16 gab1 gab1 ADJ fnp-3684 47 17 and and CCONJ fnp-3684 47 18 yap1 yap1 PROPN fnp-3684 47 19 . . PUNCT fnp-3684 48 1 ki-67 ki-67 PUNCT fnp-3684 48 2 labelling labelling NOUN fnp-3684 48 3 is be AUX fnp-3684 48 4 seen see VERB fnp-3684 48 5 almost almost ADV fnp-3684 48 6 exclusively exclusively ADV fnp-3684 48 7 in in ADP fnp-3684 48 8 the the DET fnp-3684 48 9 desmoplastic desmoplastic ADJ fnp-3684 48 10 component component NOUN fnp-3684 48 11 . . PUNCT fnp-3684 49 1 both both DET fnp-3684 49 2 components component NOUN fnp-3684 49 3 lack lack VERB fnp-3684 49 4 expression expression NOUN fnp-3684 49 5 of of ADP fnp-3684 49 6 pten pten NOUN fnp-3684 49 7 , , PUNCT fnp-3684 49 8 which which PRON fnp-3684 49 9 is be AUX fnp-3684 49 10 retained retain VERB fnp-3684 49 11 in in ADP fnp-3684 49 12 endothelial endothelial ADJ fnp-3684 49 13 cells cell NOUN fnp-3684 49 14 . . PUNCT fnp-3684 50 1 clicking click VERB fnp-3684 50 2 the the DET fnp-3684 50 3 figure figure NOUN fnp-3684 50 4 will will AUX fnp-3684 50 5 lead lead VERB fnp-3684 50 6 you you PRON fnp-3684 50 7 to to ADP fnp-3684 50 8 the the DET fnp-3684 50 9 full full ADJ fnp-3684 50 10 virtual virtual ADJ fnp-3684 50 11 slides slide NOUN fnp-3684 50 12 . . PUNCT fnp-3684 51 1 pathology pathology NOUN fnp-3684 51 2 representative representative NOUN fnp-3684 51 3 images image NOUN fnp-3684 51 4 of of ADP fnp-3684 51 5 the the DET fnp-3684 51 6 cerebellar cerebellar ADJ fnp-3684 51 7 tumor tumor NOUN fnp-3684 51 8 are be AUX fnp-3684 51 9 shown show VERB fnp-3684 51 10 in in ADP fnp-3684 51 11 figure figure NOUN fnp-3684 51 12 1 1 NUM fnp-3684 51 13 . . PUNCT fnp-3684 52 1 the the DET fnp-3684 52 2 tumor tumor NOUN fnp-3684 52 3 was be AUX fnp-3684 52 4 biphasic biphasic ADJ fnp-3684 52 5 and and CCONJ fnp-3684 52 6 had have VERB fnp-3684 52 7 a a DET fnp-3684 52 8 distinctly distinctly ADV fnp-3684 52 9 nodular nodular ADJ fnp-3684 52 10 growth growth NOUN fnp-3684 52 11 pattern pattern NOUN fnp-3684 52 12 . . PUNCT fnp-3684 53 1 most most ADJ fnp-3684 53 2 of of ADP fnp-3684 53 3 the the DET fnp-3684 53 4 tumor tumor NOUN fnp-3684 53 5 consisted consist VERB fnp-3684 53 6 of of ADP fnp-3684 53 7 large large ADJ fnp-3684 53 8 confluent confluent ADJ fnp-3684 53 9 islands island NOUN fnp-3684 53 10 of of ADP fnp-3684 53 11 isomorphic isomorphic ADJ fnp-3684 53 12 cells cell NOUN fnp-3684 53 13 with with ADP fnp-3684 53 14 a a DET fnp-3684 53 15 neurocytic neurocytic NOUN fnp-3684 53 16 to to ADP fnp-3684 53 17 gangliocytic gangliocytic ADJ fnp-3684 53 18 appearance appearance NOUN fnp-3684 53 19 , , PUNCT fnp-3684 53 20 embedded embed VERB fnp-3684 53 21 in in ADP fnp-3684 53 22 a a DET fnp-3684 53 23 finely finely ADV fnp-3684 53 24 fibrillary fibrillary ADJ fnp-3684 53 25 neuropil neuropil NOUN fnp-3684 53 26 - - PUNCT fnp-3684 53 27 like like ADJ fnp-3684 53 28 matrix matrix NOUN fnp-3684 53 29 . . PUNCT fnp-3684 54 1 these these DET fnp-3684 54 2 cells cell NOUN fnp-3684 54 3 were be AUX fnp-3684 54 4 strongly strongly ADV fnp-3684 54 5 positive positive ADJ fnp-3684 54 6 for for ADP fnp-3684 54 7 neun neun NOUN fnp-3684 54 8 and and CCONJ fnp-3684 54 9 the the DET fnp-3684 54 10 neuropil neuropil NOUN fnp-3684 54 11 stained stain VERB fnp-3684 54 12 intensely intensely ADV fnp-3684 54 13 for for ADP fnp-3684 54 14 synaptophysin synaptophysin NOUN fnp-3684 54 15 and and CCONJ fnp-3684 54 16 showed show VERB fnp-3684 54 17 bundles bundle NOUN fnp-3684 54 18 of of ADP fnp-3684 54 19 neurites neurite NOUN fnp-3684 54 20 on on ADP fnp-3684 54 21 a a DET fnp-3684 54 22 neurofilament neurofilament ADJ fnp-3684 54 23 immunostain immunostain NOUN fnp-3684 54 24 . . PUNCT fnp-3684 55 1 there there PRON fnp-3684 55 2 was be VERB fnp-3684 55 3 virtually virtually ADV fnp-3684 55 4 no no DET fnp-3684 55 5 ki-67 ki-67 ADJ fnp-3684 55 6 labelling labelling NOUN fnp-3684 55 7 in in ADP fnp-3684 55 8 this this DET fnp-3684 55 9 component component NOUN fnp-3684 55 10 and and CCONJ fnp-3684 55 11 it it PRON fnp-3684 55 12 was be AUX fnp-3684 55 13 negative negative ADJ fnp-3684 55 14 for for ADP fnp-3684 55 15 yap1 yap1 NOUN fnp-3684 55 16 and and CCONJ fnp-3684 55 17 gab1 gab1 PROPN fnp-3684 55 18 . . PUNCT fnp-3684 56 1 the the DET fnp-3684 56 2 remainder remainder NOUN fnp-3684 56 3 of of ADP fnp-3684 56 4 the the DET fnp-3684 56 5 tumor tumor NOUN fnp-3684 56 6 was be AUX fnp-3684 56 7 made make VERB fnp-3684 56 8 up up ADP fnp-3684 56 9 of of ADP fnp-3684 56 10 a a DET fnp-3684 56 11 very very ADV fnp-3684 56 12 cellular cellular ADJ fnp-3684 56 13 " " PUNCT fnp-3684 56 14 small small ADJ fnp-3684 56 15 blue blue ADJ fnp-3684 56 16 cell cell NOUN fnp-3684 56 17 " " PUNCT fnp-3684 56 18 component component NOUN fnp-3684 56 19 , , PUNCT fnp-3684 56 20 which which PRON fnp-3684 56 21 was be AUX fnp-3684 56 22 rich rich ADJ fnp-3684 56 23 in in ADP fnp-3684 56 24 reticulin reticulin ADJ fnp-3684 56 25 fibers fiber NOUN fnp-3684 56 26 , , PUNCT fnp-3684 56 27 had have VERB fnp-3684 56 28 a a DET fnp-3684 56 29 high high ADJ fnp-3684 56 30 mitotic mitotic ADJ fnp-3684 56 31 rate rate NOUN fnp-3684 56 32 with with ADP fnp-3684 56 33 approximately approximately ADV fnp-3684 56 34 50 50 NUM fnp-3684 56 35 % % NOUN fnp-3684 56 36 ki-67 ki-67 ADJ fnp-3684 56 37 labelling labelling NOUN fnp-3684 56 38 , , PUNCT fnp-3684 56 39 and and CCONJ fnp-3684 56 40 focal focal ADJ fnp-3684 56 41 immunoreactivity immunoreactivity NOUN fnp-3684 56 42 for for ADP fnp-3684 56 43 gfap gfap NOUN fnp-3684 56 44 along along ADV fnp-3684 56 45 with with ADP fnp-3684 56 46 strong strong ADJ fnp-3684 56 47 staining stain VERB fnp-3684 56 48 for for ADP fnp-3684 56 49 yap1 yap1 NOUN fnp-3684 56 50 and and CCONJ fnp-3684 56 51 gab1 gab1 PROPN fnp-3684 56 52 . . PUNCT fnp-3684 57 1 the the DET fnp-3684 57 2 features feature NOUN fnp-3684 57 3 were be AUX fnp-3684 57 4 typical typical ADJ fnp-3684 57 5 of of ADP fnp-3684 57 6 an an DET fnp-3684 57 7 mben mben NOUN fnp-3684 57 8 , , PUNCT fnp-3684 57 9 shh shh NOUN fnp-3684 57 10 - - VERB fnp-3684 57 11 activated activated ADJ fnp-3684 57 12 . . PUNCT fnp-3684 58 1 immunostaining immunostaine VERB fnp-3684 58 2 for for ADP fnp-3684 58 3 pten pten ADJ fnp-3684 58 4 and and CCONJ fnp-3684 58 5 genetic genetic ADJ fnp-3684 58 6 analysis analysis NOUN fnp-3684 58 7 of of ADP fnp-3684 58 8 the the DET fnp-3684 58 9 tumor tumor NOUN fnp-3684 58 10 were be AUX fnp-3684 58 11 performed perform VERB fnp-3684 58 12 after after SCONJ fnp-3684 58 13 the the DET fnp-3684 58 14 pten pten NOUN fnp-3684 58 15 germline germline NOUN fnp-3684 58 16 variant variant NOUN fnp-3684 58 17 was be AUX fnp-3684 58 18 identified identify VERB fnp-3684 58 19 . . PUNCT fnp-3684 59 1 expression expression NOUN fnp-3684 59 2 of of ADP fnp-3684 59 3 pten pten NOUN fnp-3684 59 4 was be AUX fnp-3684 59 5 retained retain VERB fnp-3684 59 6 in in ADP fnp-3684 59 7 vessels vessel NOUN fnp-3684 59 8 but but CCONJ fnp-3684 59 9 lost lose VERB fnp-3684 59 10 in in ADP fnp-3684 59 11 both both DET fnp-3684 59 12 tumor tumor NOUN fnp-3684 59 13 components component NOUN fnp-3684 59 14 . . PUNCT fnp-3684 60 1 the the DET fnp-3684 60 2 tumor tumor NOUN fnp-3684 60 3 carried carry VERB fnp-3684 60 4 the the DET fnp-3684 60 5 pten pten ADJ fnp-3684 60 6 p.r130 p.r130 NOUN fnp-3684 60 7 * * NOUN fnp-3684 60 8 variant variant NOUN fnp-3684 60 9 , , PUNCT fnp-3684 60 10 as as SCONJ fnp-3684 60 11 expected expect VERB fnp-3684 60 12 . . PUNCT fnp-3684 61 1 in in ADP fnp-3684 61 2 addition addition NOUN fnp-3684 61 3 , , PUNCT fnp-3684 61 4 using use VERB fnp-3684 61 5 a a DET fnp-3684 61 6 truseq truseq NOUN fnp-3684 61 7 custom custom NOUN fnp-3684 61 8 amplicon amplicon NOUN fnp-3684 61 9 ( ( PUNCT fnp-3684 61 10 illumina illumina PROPN fnp-3684 61 11 ) ) PUNCT fnp-3684 61 12 for for ADP fnp-3684 61 13 13 13 NUM fnp-3684 61 14 genes gene NOUN fnp-3684 61 15 frequently frequently ADV fnp-3684 61 16 mutated mutate VERB fnp-3684 61 17 in in ADP fnp-3684 61 18 shh shh NOUN fnp-3684 61 19 - - PUNCT fnp-3684 61 20 medulloblastomas medulloblastoma NOUN fnp-3684 61 21 [ [ X fnp-3684 61 22 goschzik goschzik NOUN fnp-3684 61 23 et et PROPN fnp-3684 61 24 al al PROPN fnp-3684 61 25 . . PROPN fnp-3684 61 26 2021 2021 NUM fnp-3684 61 27 ] ] PUNCT fnp-3684 61 28 , , PUNCT fnp-3684 61 29 a a DET fnp-3684 61 30 known know VERB fnp-3684 61 31 pathogenic pathogenic ADJ fnp-3684 61 32 variant variant NOUN fnp-3684 61 33 in in ADP fnp-3684 61 34 smo smo PROPN fnp-3684 61 35 , , PUNCT fnp-3684 61 36 c.1234c c.1234c NOUN fnp-3684 61 37 > > X fnp-3684 61 38 t t PROPN fnp-3684 61 39 , , PUNCT fnp-3684 61 40 p.l412f p.l412f NOUN fnp-3684 61 41 ( ( PUNCT fnp-3684 61 42 cosv50824425 cosv50824425 PROPN fnp-3684 61 43 ) ) PUNCT fnp-3684 61 44 , , PUNCT fnp-3684 61 45 was be AUX fnp-3684 61 46 identified identify VERB fnp-3684 61 47 , , PUNCT fnp-3684 61 48 which which PRON fnp-3684 61 49 was be AUX fnp-3684 61 50 confirmed confirm VERB fnp-3684 61 51 by by ADP fnp-3684 61 52 sanger sanger PROPN fnp-3684 61 53 sequencing sequencing NOUN fnp-3684 61 54 . . PUNCT fnp-3684 62 1 molecular molecular ADJ fnp-3684 62 2 inversion inversion NOUN fnp-3684 62 3 probe probe NOUN fnp-3684 62 4 technology technology NOUN fnp-3684 62 5 was be AUX fnp-3684 62 6 used use VERB fnp-3684 62 7 to to PART fnp-3684 62 8 perform perform VERB fnp-3684 62 9 high high ADJ fnp-3684 62 10 - - PUNCT fnp-3684 62 11 resolution resolution NOUN fnp-3684 62 12 genome genome NOUN fnp-3684 62 13 - - PUNCT fnp-3684 62 14 wide wide ADJ fnp-3684 62 15 copy copy NOUN fnp-3684 62 16 number number NOUN fnp-3684 62 17 analysis analysis NOUN fnp-3684 62 18 as as SCONJ fnp-3684 62 19 described describe VERB fnp-3684 62 20 previously previously ADV fnp-3684 62 21 [ [ X fnp-3684 62 22 wang wang PROPN fnp-3684 62 23 et et PROPN fnp-3684 62 24 al al PROPN fnp-3684 62 25 . . PROPN fnp-3684 62 26 2012 2012 NUM fnp-3684 62 27 ] ] PUNCT fnp-3684 62 28 . . PUNCT fnp-3684 63 1 it it PRON fnp-3684 63 2 showed show VERB fnp-3684 63 3 a a DET fnp-3684 63 4 stable stable ADJ fnp-3684 63 5 genome genome NOUN fnp-3684 63 6 with with ADP fnp-3684 63 7 copy copy NOUN fnp-3684 63 8 - - PUNCT fnp-3684 63 9 neutral neutral ADJ fnp-3684 63 10 allelic allelic ADJ fnp-3684 63 11 loss loss NOUN fnp-3684 63 12 on on ADP fnp-3684 63 13 chromosome chromosome NOUN fnp-3684 63 14 arm arm NOUN fnp-3684 63 15 10q 10q NOUN fnp-3684 63 16 . . PUNCT fnp-3684 64 1 there there PRON fnp-3684 64 2 was be VERB fnp-3684 64 3 no no DET fnp-3684 64 4 amplification amplification NOUN fnp-3684 64 5 of of ADP fnp-3684 64 6 myc myc NOUN fnp-3684 64 7 or or CCONJ fnp-3684 64 8 mycn mycn NOUN fnp-3684 64 9 . . PUNCT fnp-3684 65 1 discussion discussion NOUN fnp-3684 65 2 cowden cowden PROPN fnp-3684 65 3 syndrome syndrome PROPN fnp-3684 65 4 ( ( PUNCT fnp-3684 65 5 omim omim PROPN fnp-3684 65 6 # # SYM fnp-3684 65 7 158350 158350 NUM fnp-3684 65 8 ) ) PUNCT fnp-3684 65 9 is be AUX fnp-3684 65 10 an an DET fnp-3684 65 11 autosomal autosomal ADJ fnp-3684 65 12 dominant dominant ADJ fnp-3684 65 13 hamartoma hamartoma NOUN fnp-3684 65 14 and and CCONJ fnp-3684 65 15 tumor tumor NOUN fnp-3684 65 16 predisposition predisposition NOUN fnp-3684 65 17 syndrome syndrome NOUN fnp-3684 65 18 caused cause VERB fnp-3684 65 19 by by ADP fnp-3684 65 20 heterozygous heterozygous ADJ fnp-3684 65 21 pathogenic pathogenic ADJ fnp-3684 65 22 germline germline NOUN fnp-3684 65 23 variants variant NOUN fnp-3684 65 24 in in ADP fnp-3684 65 25 pten pten NOUN fnp-3684 65 26 in in ADP fnp-3684 65 27 about about ADV fnp-3684 65 28 80 80 NUM fnp-3684 65 29 % % NOUN fnp-3684 65 30 of of ADP fnp-3684 65 31 affected affect VERB fnp-3684 65 32 individuals individual NOUN fnp-3684 65 33 [ [ X fnp-3684 65 34 yehia yehia PROPN fnp-3684 65 35 & & CCONJ fnp-3684 65 36 eng eng PROPN fnp-3684 65 37 2001/2021 2001/2021 NUM fnp-3684 65 38 ] ] PUNCT fnp-3684 65 39 . . PUNCT fnp-3684 66 1 major major ADJ fnp-3684 66 2 features feature NOUN fnp-3684 66 3 include include VERB fnp-3684 66 4 macrocrania macrocrania NOUN fnp-3684 66 5 , , PUNCT fnp-3684 66 6 multiple multiple ADJ fnp-3684 66 7 facial facial ADJ fnp-3684 66 8 tricholemmomas tricholemmoma NOUN fnp-3684 66 9 , , PUNCT fnp-3684 66 10 acral acral ADJ fnp-3684 66 11 and and CCONJ fnp-3684 66 12 oral oral ADJ fnp-3684 66 13 keratoses keratose NOUN fnp-3684 66 14 and and CCONJ fnp-3684 66 15 papillomas papilloma NOUN fnp-3684 66 16 , , PUNCT fnp-3684 66 17 as as ADV fnp-3684 66 18 well well ADV fnp-3684 66 19 as as ADP fnp-3684 66 20 mammary mammary ADJ fnp-3684 66 21 , , PUNCT fnp-3684 66 22 non non ADJ fnp-3684 66 23 - - ADJ fnp-3684 66 24 medullary medullary ADJ fnp-3684 66 25 thyroid thyroid NOUN fnp-3684 66 26 , , PUNCT fnp-3684 66 27 renal renal ADJ fnp-3684 66 28 , , PUNCT fnp-3684 66 29 and and CCONJ fnp-3684 66 30 endometrial endometrial ADJ fnp-3684 66 31 carcinomas carcinoma NOUN fnp-3684 66 32 [ [ PUNCT fnp-3684 66 33 yehia yehia NOUN fnp-3684 66 34 & & CCONJ fnp-3684 66 35 eng eng PROPN fnp-3684 66 36 2001/2021 2001/2021 NUM fnp-3684 66 37 ] ] PUNCT fnp-3684 66 38 . . PUNCT fnp-3684 67 1 lhermitte lhermitte NOUN fnp-3684 67 2 - - PUNCT fnp-3684 67 3 duclos duclo NOUN fnp-3684 67 4 disease disease NOUN fnp-3684 67 5 ( ( PUNCT fnp-3684 67 6 ldd ldd PROPN fnp-3684 67 7 ) ) PUNCT fnp-3684 67 8 , , PUNCT fnp-3684 67 9 or or CCONJ fnp-3684 67 10 dysplastic dysplastic ADJ fnp-3684 67 11 gangliocytoma gangliocytoma NOUN fnp-3684 67 12 of of ADP fnp-3684 67 13 the the DET fnp-3684 67 14 cerebellum cerebellum NOUN fnp-3684 67 15 , , PUNCT fnp-3684 67 16 is be AUX fnp-3684 67 17 the the DET fnp-3684 67 18 typical typical ADJ fnp-3684 67 19 brain brain NOUN fnp-3684 67 20 tumor tumor NOUN fnp-3684 67 21 associated associate VERB fnp-3684 67 22 with with ADP fnp-3684 67 23 cs cs PROPN fnp-3684 67 24 ; ; PUNCT fnp-3684 67 25 in in ADP fnp-3684 67 26 fact fact NOUN fnp-3684 67 27 , , PUNCT fnp-3684 67 28 in in ADP fnp-3684 67 29 adults adult NOUN fnp-3684 67 30 , , PUNCT fnp-3684 67 31 ldd ldd PROPN fnp-3684 67 32 is be AUX fnp-3684 67 33 considered consider VERB fnp-3684 67 34 pathognomonic pathognomonic ADJ fnp-3684 67 35 of of ADP fnp-3684 67 36 cs cs PROPN fnp-3684 67 37 [ [ X fnp-3684 67 38 yehia yehia PROPN fnp-3684 67 39 & & CCONJ fnp-3684 67 40 eng eng PROPN fnp-3684 67 41 2001/2021 2001/2021 NUM fnp-3684 67 42 ] ] PUNCT fnp-3684 67 43 . . PUNCT fnp-3684 68 1 conversely conversely ADV fnp-3684 68 2 , , PUNCT fnp-3684 68 3 the the DET fnp-3684 68 4 lifetime lifetime NOUN fnp-3684 68 5 risk risk NOUN fnp-3684 68 6 for for ADP fnp-3684 68 7 ldd ldd PROPN fnp-3684 68 8 in in ADP fnp-3684 68 9 cs cs ADJ fnp-3684 68 10 patients patient NOUN fnp-3684 68 11 has have AUX fnp-3684 68 12 been be AUX fnp-3684 68 13 reported report VERB fnp-3684 68 14 to to PART fnp-3684 68 15 be be AUX fnp-3684 68 16 as as ADV fnp-3684 68 17 high high ADJ fnp-3684 68 18 as as ADP fnp-3684 68 19 30 30 NUM fnp-3684 68 20 % % NOUN fnp-3684 69 1 [ [ X fnp-3684 69 2 riegert riegert NOUN fnp-3684 69 3 - - PUNCT fnp-3684 69 4 johnson johnson PROPN fnp-3684 69 5 et et PROPN fnp-3684 69 6 al al PROPN fnp-3684 69 7 . . PROPN fnp-3684 69 8 2010 2010 NUM fnp-3684 69 9 ] ] PUNCT fnp-3684 69 10 . . PUNCT fnp-3684 70 1 in in ADP fnp-3684 70 2 contrast contrast NOUN fnp-3684 70 3 , , PUNCT fnp-3684 70 4 the the DET fnp-3684 70 5 association association NOUN fnp-3684 70 6 between between ADP fnp-3684 70 7 cs cs PROPN fnp-3684 70 8 and and CCONJ fnp-3684 70 9 medulloblastoma medulloblastoma NOUN fnp-3684 70 10 is be AUX fnp-3684 70 11 very very ADV fnp-3684 70 12 rare rare ADJ fnp-3684 70 13 . . PUNCT fnp-3684 71 1 in in ADP fnp-3684 71 2 a a DET fnp-3684 71 3 study study NOUN fnp-3684 71 4 of of ADP fnp-3684 71 5 914 914 NUM fnp-3684 71 6 children child NOUN fnp-3684 71 7 and and CCONJ fnp-3684 71 8 adolescents adolescent NOUN fnp-3684 71 9 with with ADP fnp-3684 71 10 cancer cancer NOUN fnp-3684 71 11 , , PUNCT fnp-3684 71 12 including include VERB fnp-3684 71 13 227 227 NUM fnp-3684 71 14 with with ADP fnp-3684 71 15 medulloblastoma medulloblastoma NOUN fnp-3684 71 16 , , PUNCT fnp-3684 71 17 no no DET fnp-3684 71 18 pten pten NOUN fnp-3684 71 19 germline germline NOUN fnp-3684 71 20 variants variant NOUN fnp-3684 71 21 were be AUX fnp-3684 71 22 identified identify VERB fnp-3684 71 23 [ [ PUNCT fnp-3684 71 24 gröbner gröbner NOUN fnp-3684 71 25 et et PROPN fnp-3684 71 26 al al PROPN fnp-3684 71 27 . . PROPN fnp-3684 71 28 2018 2018 NUM fnp-3684 71 29 ] ] PUNCT fnp-3684 71 30 . . PUNCT fnp-3684 72 1 similarly similarly ADV fnp-3684 72 2 , , PUNCT fnp-3684 72 3 among among ADP fnp-3684 72 4 1022 1022 NUM fnp-3684 72 5 medulloblastoma medulloblastoma NOUN fnp-3684 72 6 patients patient NOUN fnp-3684 72 7 screened screen VERB fnp-3684 72 8 for for ADP fnp-3684 72 9 germline germline NOUN fnp-3684 72 10 variants variant NOUN fnp-3684 72 11 in in ADP fnp-3684 72 12 110 110 NUM fnp-3684 72 13 cancer cancer NOUN fnp-3684 72 14 predisposition predisposition NOUN fnp-3684 72 15 genes gene NOUN fnp-3684 72 16 , , PUNCT fnp-3684 72 17 only only ADV fnp-3684 72 18 one one NUM fnp-3684 72 19 pathogenic pathogenic ADJ fnp-3684 72 20 variant variant NOUN fnp-3684 72 21 was be AUX fnp-3684 72 22 reported report VERB fnp-3684 72 23 in in ADP fnp-3684 72 24 pten pten NOUN fnp-3684 73 1 [ [ PUNCT fnp-3684 73 2 waszak waszak X fnp-3684 73 3 et et PROPN fnp-3684 73 4 al al PROPN fnp-3684 73 5 . . PROPN fnp-3684 73 6 2018 2018 NUM fnp-3684 73 7 ] ] PUNCT fnp-3684 73 8 . . PUNCT fnp-3684 74 1 in in ADP fnp-3684 74 2 a a DET fnp-3684 74 3 clinical clinical ADJ fnp-3684 74 4 cohort cohort NOUN fnp-3684 74 5 of of ADP fnp-3684 74 6 368 368 NUM fnp-3684 74 7 patients patient NOUN fnp-3684 74 8 with with ADP fnp-3684 74 9 cowden cowden PROPN fnp-3684 74 10 syndrome syndrome PROPN fnp-3684 74 11 and and CCONJ fnp-3684 74 12 pathogenic pathogenic ADJ fnp-3684 74 13 pten pten NOUN fnp-3684 74 14 germline germline NOUN fnp-3684 74 15 variants variant NOUN fnp-3684 74 16 ( ( PUNCT fnp-3684 74 17 including include VERB fnp-3684 74 18 98 98 NUM fnp-3684 74 19 patients patient NOUN fnp-3684 74 20 under under ADP fnp-3684 74 21 the the DET fnp-3684 74 22 age age NOUN fnp-3684 74 23 of of ADP fnp-3684 74 24 18 18 NUM fnp-3684 74 25 years year NOUN fnp-3684 74 26 ) ) PUNCT fnp-3684 74 27 recruited recruit VERB fnp-3684 74 28 and and CCONJ fnp-3684 74 29 followed follow VERB fnp-3684 74 30 prospectively prospectively ADV fnp-3684 74 31 by by ADP fnp-3684 74 32 an an DET fnp-3684 74 33 international international ADJ fnp-3684 74 34 consortium consortium NOUN fnp-3684 74 35 between between ADP fnp-3684 74 36 2000 2000 NUM fnp-3684 74 37 and and CCONJ fnp-3684 74 38 2010 2010 NUM fnp-3684 74 39 , , PUNCT fnp-3684 74 40 no no DET fnp-3684 74 41 cases case NOUN fnp-3684 74 42 of of ADP fnp-3684 74 43 medulloblastoma medulloblastoma NOUN fnp-3684 74 44 were be AUX fnp-3684 74 45 reported report VERB fnp-3684 75 1 [ [ PUNCT fnp-3684 75 2 tan tan NOUN fnp-3684 75 3 et et PROPN fnp-3684 75 4 al al PROPN fnp-3684 75 5 . . PROPN fnp-3684 75 6 2012 2012 NUM fnp-3684 75 7 ] ] PUNCT fnp-3684 75 8 . . PUNCT fnp-3684 76 1 on on ADP fnp-3684 76 2 the the DET fnp-3684 76 3 other other ADJ fnp-3684 76 4 hand hand NOUN fnp-3684 76 5 , , PUNCT fnp-3684 76 6 including include VERB fnp-3684 76 7 this this DET fnp-3684 76 8 case case NOUN fnp-3684 76 9 , , PUNCT fnp-3684 76 10 five five NUM fnp-3684 76 11 patients patient NOUN fnp-3684 76 12 with with ADP fnp-3684 76 13 cs cs PROPN fnp-3684 76 14 and and CCONJ fnp-3684 76 15 medulloblastoma medulloblastoma NOUN fnp-3684 76 16 have have AUX fnp-3684 76 17 now now ADV fnp-3684 76 18 been be AUX fnp-3684 76 19 reported report VERB fnp-3684 76 20 in in ADP fnp-3684 76 21 the the DET fnp-3684 76 22 literature literature NOUN fnp-3684 76 23 ; ; PUNCT fnp-3684 76 24 they they PRON fnp-3684 76 25 are be AUX fnp-3684 76 26 summarized summarize VERB fnp-3684 76 27 in in ADP fnp-3684 76 28 table table NOUN fnp-3684 76 29 1 1 NUM fnp-3684 76 30 . . PUNCT fnp-3684 77 1 patient patient NOUN fnp-3684 77 2 1 1 NUM fnp-3684 77 3 was be AUX fnp-3684 77 4 reported report VERB fnp-3684 77 5 before before SCONJ fnp-3684 77 6 the the DET fnp-3684 77 7 genetic genetic ADJ fnp-3684 77 8 defect defect NOUN fnp-3684 77 9 in in ADP fnp-3684 77 10 cs cs PROPN fnp-3684 77 11 was be AUX fnp-3684 77 12 known know VERB fnp-3684 77 13 [ [ PUNCT fnp-3684 77 14 bagan bagan X fnp-3684 77 15 et et PROPN fnp-3684 77 16 al al PROPN fnp-3684 77 17 . . PROPN fnp-3684 77 18 1989 1989 NUM fnp-3684 77 19 ] ] PUNCT fnp-3684 77 20 , , PUNCT fnp-3684 77 21 hence hence ADV fnp-3684 77 22 the the DET fnp-3684 77 23 diagnosis diagnosis NOUN fnp-3684 77 24 of of ADP fnp-3684 77 25 cs cs PROPN fnp-3684 77 26 is be AUX fnp-3684 77 27 based base VERB fnp-3684 77 28 on on ADP fnp-3684 77 29 the the DET fnp-3684 77 30 clinical clinical ADJ fnp-3684 77 31 findings finding NOUN fnp-3684 78 1 [ [ X fnp-3684 78 2 eng eng NOUN fnp-3684 78 3 2000 2000 NUM fnp-3684 78 4 ] ] PUNCT fnp-3684 78 5 ; ; PUNCT fnp-3684 78 6 he he PRON fnp-3684 78 7 has have AUX fnp-3684 78 8 since since ADV fnp-3684 78 9 been be AUX fnp-3684 78 10 lost lose VERB fnp-3684 78 11 to to PART fnp-3684 78 12 follow follow VERB fnp-3684 78 13 - - PUNCT fnp-3684 78 14 up up NOUN fnp-3684 78 15 ( ( PUNCT fnp-3684 78 16 j.v j.v PROPN fnp-3684 78 17 . . PROPN fnp-3684 78 18 bagan bagan PROPN fnp-3684 78 19 , , PUNCT fnp-3684 78 20 personal personal ADJ fnp-3684 78 21 communication communication NOUN fnp-3684 78 22 ) ) PUNCT fnp-3684 78 23 . . PUNCT fnp-3684 79 1 the the DET fnp-3684 79 2 four four NUM fnp-3684 79 3 other other ADJ fnp-3684 79 4 patients patient NOUN fnp-3684 79 5 carried carry VERB fnp-3684 79 6 a a DET fnp-3684 79 7 pathogenic pathogenic ADJ fnp-3684 79 8 germline germline NOUN fnp-3684 79 9 variant variant NOUN fnp-3684 79 10 in in ADP fnp-3684 79 11 pten pten NOUN fnp-3684 79 12 . . PUNCT fnp-3684 80 1 given give VERB fnp-3684 80 2 the the DET fnp-3684 80 3 rarity rarity NOUN fnp-3684 80 4 of of ADP fnp-3684 80 5 cs cs PROPN fnp-3684 80 6 , , PUNCT fnp-3684 80 7 with with ADP fnp-3684 80 8 an an DET fnp-3684 80 9 estimated estimate VERB fnp-3684 80 10 prevalence prevalence NOUN fnp-3684 80 11 of of ADP fnp-3684 80 12 1 1 NUM fnp-3684 80 13 in in ADP fnp-3684 80 14 200,000 200,000 NUM fnp-3684 80 15 [ [ PUNCT fnp-3684 80 16 yehia yehia PROPN fnp-3684 80 17 & & CCONJ fnp-3684 80 18 eng eng PROPN fnp-3684 80 19 2001/2021 2001/2021 NUM fnp-3684 80 20 ] ] PUNCT fnp-3684 80 21 , , PUNCT fnp-3684 80 22 this this PRON fnp-3684 80 23 is be AUX fnp-3684 80 24 unlikely unlikely ADJ fnp-3684 80 25 to to PART fnp-3684 80 26 be be AUX fnp-3684 80 27 a a DET fnp-3684 80 28 coincidence coincidence NOUN fnp-3684 80 29 . . PUNCT fnp-3684 81 1 table table NOUN fnp-3684 81 2 1 1 NUM fnp-3684 81 3 : : PUNCT fnp-3684 81 4 patients patient NOUN fnp-3684 81 5 with with ADP fnp-3684 81 6 cowden cowden PROPN fnp-3684 81 7 syndrome syndrome PROPN fnp-3684 81 8 and and CCONJ fnp-3684 81 9 medulloblastoma medulloblastoma NOUN fnp-3684 81 10 . . PUNCT fnp-3684 82 1 case case NOUN fnp-3684 82 2 sex sex NOUN fnp-3684 82 3 / / SYM fnp-3684 82 4 age age NOUN fnp-3684 82 5 at at ADP fnp-3684 82 6 diagnosis diagnosis NOUN fnp-3684 82 7 ( ( PUNCT fnp-3684 82 8 case case NOUN fnp-3684 83 1 i i PRON fnp-3684 83 2 d d NOUN fnp-3684 83 3 if if SCONJ fnp-3684 83 4 applicable applicable ADJ fnp-3684 83 5 ) ) PUNCT fnp-3684 83 6 mb mb ADP fnp-3684 83 7 subtype subtype NOUN fnp-3684 83 8 ( ( PUNCT fnp-3684 83 9 histology histology NOUN fnp-3684 83 10 if if SCONJ fnp-3684 83 11 known know VERB fnp-3684 83 12 ) ) PUNCT fnp-3684 83 13 germline germline NOUN fnp-3684 83 14 pten pten VERB fnp-3684 83 15 variant variant ADJ fnp-3684 83 16 additional additional ADJ fnp-3684 83 17 variants variant NOUN fnp-3684 83 18 and/or and/or CCONJ fnp-3684 83 19 other other ADJ fnp-3684 83 20 genetic genetic ADJ fnp-3684 83 21 changes change NOUN fnp-3684 83 22 in in ADP fnp-3684 83 23 tumor tumor NOUN fnp-3684 83 24 status status NOUN fnp-3684 83 25 reference reference NOUN fnp-3684 83 26                             SPACE fnp-3684 83 27 1 1 NUM fnp-3684 83 28 m/2 m/2 NUM fnp-3684 83 29 y y PROPN fnp-3684 83 30 ( ( PUNCT fnp-3684 83 31 case case NOUN fnp-3684 83 32 2 2 NUM fnp-3684 83 33 ) ) PUNCT fnp-3684 83 34 na na PART fnp-3684 83 35 na na VERB fnp-3684 83 36 na na PART fnp-3684 83 37 ned ne VERB fnp-3684 83 38 at at ADP fnp-3684 83 39 19 19 NUM fnp-3684 83 40 y y PROPN fnp-3684 83 41 bagan bagan PROPN fnp-3684 83 42 et et PROPN fnp-3684 83 43 al al PROPN fnp-3684 83 44 . . PROPN fnp-3684 83 45 1989 1989 NUM fnp-3684 83 46                             SPACE fnp-3684 83 47 2 2 NUM fnp-3684 83 48 m/2 m/2 NUM fnp-3684 83 49 y y PROPN fnp-3684 83 50 ns ns INTJ fnp-3684 83 51 c.697c c.697c PROPN fnp-3684 83 52 > > SYM fnp-3684 83 53 t t PROPN fnp-3684 83 54 , , PUNCT fnp-3684 83 55 p.r233 p.r233 PROPN fnp-3684 83 56 * * NOUN fnp-3684 83 57 nd nd PRON fnp-3684 83 58 ned ne VERB fnp-3684 83 59 at at ADP fnp-3684 83 60 14 14 NUM fnp-3684 83 61 y y PROPN fnp-3684 83 62 patini patini PROPN fnp-3684 83 63 et et PROPN fnp-3684 83 64 al al PROPN fnp-3684 83 65 . . PROPN fnp-3684 83 66 2016 2016 NUM fnp-3684 83 67                             SPACE fnp-3684 83 68 3 3 NUM fnp-3684 83 69 f/1 f/1 PROPN fnp-3684 83 70 y y PROPN fnp-3684 83 71 ( ( PUNCT fnp-3684 83 72 icgc_mb217 icgc_mb217 NOUN fnp-3684 83 73 ) ) PUNCT fnp-3684 83 74 shh shh PROPN fnp-3684 83 75 c.856dela c.856dela PROPN fnp-3684 83 76 , , PUNCT fnp-3684 83 77 p.t286pfs*5 p.t286pfs*5 PROPN fnp-3684 83 78 loss loss NOUN fnp-3684 83 79 of of ADP fnp-3684 83 80 heterozygosity heterozygosity NOUN fnp-3684 83 81 ns ns INTJ fnp-3684 83 82 waszak waszak NOUN fnp-3684 83 83 et et PROPN fnp-3684 83 84 al al PROPN fnp-3684 83 85 . . PROPN fnp-3684 83 86 2018 2018 NUM fnp-3684 83 87                             SPACE fnp-3684 83 88 4 4 NUM fnp-3684 83 89 f/14 f/14 PROPN fnp-3684 83 90 mo mo PROPN fnp-3684 83 91 shh shh PROPN fnp-3684 83 92 ( ( PUNCT fnp-3684 83 93 dn¶ dn¶ ADJ fnp-3684 83 94 ) ) PUNCT fnp-3684 83 95 c.18dup c.18dup NOUN fnp-3684 83 96 , , PUNCT fnp-3684 83 97 p.e7rfs*4 p.e7rfs*4 PROPN fnp-3684 83 98 sufu sufu X fnp-3684 83 99 c.412delinscc c.412delinscc PROPN fnp-3684 83 100 , , PUNCT fnp-3684 83 101 p.a138pfs*32 p.a138pfs*32 PROPN fnp-3684 83 102 kdr kdr PROPN fnp-3684 83 103 c.787c c.787c PROPN fnp-3684 83 104 > > PROPN fnp-3684 83 105 a a PRON fnp-3684 83 106 , , PUNCT fnp-3684 83 107 p.p263 p.p263 PROPN fnp-3684 83 108 t t NOUN fnp-3684 83 109 ned ne VERB fnp-3684 83 110 at at ADP fnp-3684 83 111 5½ 5½ PROPN fnp-3684 83 112 y¶ y¶ PUNCT fnp-3684 83 113 tolonen tolonen NOUN fnp-3684 83 114 et et PROPN fnp-3684 83 115 al al PROPN fnp-3684 83 116 . . PROPN fnp-3684 83 117 2020 2020 NUM fnp-3684 83 118                             SPACE fnp-3684 83 119 5 5 NUM fnp-3684 83 120 f/15 f/15 PROPN fnp-3684 83 121 mo mo PROPN fnp-3684 83 122 shh shh PROPN fnp-3684 83 123 ( ( PUNCT fnp-3684 83 124 mben mben PROPN fnp-3684 83 125 ) ) PUNCT fnp-3684 83 126 c.388c c.388c PROPN fnp-3684 83 127 > > PROPN fnp-3684 83 128 t t PROPN fnp-3684 83 129 , , PUNCT fnp-3684 83 130 p.r130 p.r130 PROPN fnp-3684 83 131 * * PUNCT fnp-3684 83 132 smo smo PROPN fnp-3684 83 133 c.1234c c.1234c PROPN fnp-3684 83 134 > > X fnp-3684 83 135 t t PROPN fnp-3684 83 136 , , PUNCT fnp-3684 83 137 p.l412f p.l412f NOUN fnp-3684 83 138 copy copy NOUN fnp-3684 83 139 - - PUNCT fnp-3684 83 140 neutral neutral ADJ fnp-3684 83 141 allelic allelic ADJ fnp-3684 83 142 loss loss NOUN fnp-3684 83 143 on on ADP fnp-3684 83 144 10q 10q NOUN fnp-3684 83 145 ned ne VERB fnp-3684 83 146 at at ADP fnp-3684 83 147 13 13 NUM fnp-3684 83 148 y y PROPN fnp-3684 83 149 current current ADJ fnp-3684 83 150 report report NOUN fnp-3684 83 151 abbreviations abbreviation NOUN fnp-3684 83 152 : : PUNCT fnp-3684 83 153 dn dn ADJ fnp-3684 83 154 , , PUNCT fnp-3684 83 155 desmoplastic desmoplastic ADJ fnp-3684 83 156 nodular nodular ADJ fnp-3684 83 157 ; ; PUNCT fnp-3684 83 158 mb mb ADJ fnp-3684 83 159 , , PUNCT fnp-3684 83 160 medulloblastoma medulloblastoma ADJ fnp-3684 83 161 ; ; PUNCT fnp-3684 83 162 mben mben NOUN fnp-3684 83 163 , , PUNCT fnp-3684 83 164 medulloblastoma medulloblastoma ADJ fnp-3684 83 165 with with ADP fnp-3684 83 166 extensive extensive ADJ fnp-3684 83 167 nodularity nodularity NOUN fnp-3684 83 168 ; ; PUNCT fnp-3684 83 169 mo mo NOUN fnp-3684 83 170 , , PUNCT fnp-3684 83 171 month month NOUN fnp-3684 83 172 ; ; PUNCT fnp-3684 83 173 na na PART fnp-3684 83 174 , , PUNCT fnp-3684 83 175 not not PART fnp-3684 83 176 applicable applicable ADJ fnp-3684 83 177 ; ; PUNCT fnp-3684 83 178 nd nd X fnp-3684 83 179 , , PUNCT fnp-3684 83 180 not not PART fnp-3684 83 181 done do VERB fnp-3684 83 182 ; ; PUNCT fnp-3684 83 183 ned ne VERB fnp-3684 83 184 , , PUNCT fnp-3684 83 185 no no DET fnp-3684 83 186 evidence evidence NOUN fnp-3684 83 187 of of ADP fnp-3684 83 188 disease disease NOUN fnp-3684 83 189 ; ; PUNCT fnp-3684 83 190 ns ns X fnp-3684 83 191 , , PUNCT fnp-3684 83 192 not not PART fnp-3684 83 193 stated state VERB fnp-3684 83 194 ; ; PUNCT fnp-3684 83 195 y y PROPN fnp-3684 83 196 , , PUNCT fnp-3684 83 197 year year PROPN fnp-3684 83 198 ¶ ¶ PROPN fnp-3684 83 199 r. r. PROPN fnp-3684 83 200 niinimäki niinimäki PROPN fnp-3684 83 201 , , PUNCT fnp-3684 83 202 personal personal ADJ fnp-3684 83 203 communication communication NOUN fnp-3684 83 204 interestingly interestingly ADV fnp-3684 83 205 , , PUNCT fnp-3684 83 206 in in ADP fnp-3684 83 207 the the DET fnp-3684 83 208 three three NUM fnp-3684 83 209 cases case NOUN fnp-3684 83 210 in in ADP fnp-3684 83 211 which which PRON fnp-3684 83 212 a a DET fnp-3684 83 213 detailed detailed ADJ fnp-3684 83 214 analysis analysis NOUN fnp-3684 83 215 of of ADP fnp-3684 83 216 the the DET fnp-3684 83 217 medulloblastoma medulloblastoma NOUN fnp-3684 83 218 was be AUX fnp-3684 83 219 performed perform VERB fnp-3684 83 220 , , PUNCT fnp-3684 83 221 it it PRON fnp-3684 83 222 was be AUX fnp-3684 83 223 an an DET fnp-3684 83 224 shh shh NOUN fnp-3684 83 225 - - PUNCT fnp-3684 83 226 activated activate VERB fnp-3684 83 227 medulloblastoma medulloblastoma NOUN fnp-3684 83 228 . . PUNCT fnp-3684 84 1 two two NUM fnp-3684 84 2 of of ADP fnp-3684 84 3 them they PRON fnp-3684 84 4 also also ADV fnp-3684 84 5 had have VERB fnp-3684 84 6 an an DET fnp-3684 84 7 additional additional ADJ fnp-3684 84 8 pathogenic pathogenic ADJ fnp-3684 84 9 variant variant NOUN fnp-3684 84 10 in in ADP fnp-3684 84 11 a a DET fnp-3684 84 12 component component NOUN fnp-3684 84 13 of of ADP fnp-3684 84 14 the the DET fnp-3684 84 15 shh shh NOUN fnp-3684 84 16 - - NOUN fnp-3684 84 17 pathway pathway NOUN fnp-3684 84 18 and and CCONJ fnp-3684 84 19 2 2 NUM fnp-3684 84 20 showed show VERB fnp-3684 84 21 allelic allelic ADJ fnp-3684 84 22 loss loss NOUN fnp-3684 84 23 involving involve VERB fnp-3684 84 24 pten/10q pten/10q NOUN fnp-3684 84 25 . . PUNCT fnp-3684 85 1 this this DET fnp-3684 85 2 mirrors mirror NOUN fnp-3684 85 3 findings finding VERB fnp-3684 85 4 in in ADP fnp-3684 85 5 sporadic sporadic ADJ fnp-3684 85 6 medulloblastomas medulloblastoma NOUN fnp-3684 85 7 , , PUNCT fnp-3684 85 8 where where SCONJ fnp-3684 85 9 mutations mutation NOUN fnp-3684 85 10 or or CCONJ fnp-3684 85 11 deletions deletion NOUN fnp-3684 85 12 of of ADP fnp-3684 85 13 pten pten NOUN fnp-3684 85 14 are be AUX fnp-3684 85 15 more more ADV fnp-3684 85 16 frequent frequent ADJ fnp-3684 85 17 in in ADP fnp-3684 85 18 shh shh NOUN fnp-3684 85 19 - - PUNCT fnp-3684 85 20 medulloblastomas medulloblastoma NOUN fnp-3684 85 21 than than ADP fnp-3684 85 22 in in ADP fnp-3684 85 23 other other ADJ fnp-3684 85 24 medulloblastoma medulloblastoma ADJ fnp-3684 85 25 subtypes subtype NOUN fnp-3684 85 26 [ [ X fnp-3684 85 27 northcott northcott PROPN fnp-3684 85 28 et et PROPN fnp-3684 85 29 al al PROPN fnp-3684 85 30 . . PROPN fnp-3684 85 31 2012 2012 NUM fnp-3684 85 32 ] ] PUNCT fnp-3684 85 33 . . PUNCT fnp-3684 86 1 furthermore furthermore ADV fnp-3684 86 2 , , PUNCT fnp-3684 86 3 in in ADP fnp-3684 86 4 mouse mouse NOUN fnp-3684 86 5 models model NOUN fnp-3684 86 6 of of ADP fnp-3684 86 7 shh shh NOUN fnp-3684 86 8 - - PUNCT fnp-3684 86 9 medulloblastomas medulloblastoma NOUN fnp-3684 86 10 driven drive VERB fnp-3684 86 11 either either CCONJ fnp-3684 86 12 by by ADP fnp-3684 86 13 inactivation inactivation NOUN fnp-3684 86 14 of of ADP fnp-3684 86 15 ptch1 ptch1 PROPN fnp-3684 87 1 [ [ X fnp-3684 87 2 metcalfe metcalfe PROPN fnp-3684 87 3 et et PROPN fnp-3684 87 4 al al PROPN fnp-3684 87 5 . . PROPN fnp-3684 87 6 2013 2013 NUM fnp-3684 87 7 ] ] PUNCT fnp-3684 87 8 or or CCONJ fnp-3684 87 9 activation activation NOUN fnp-3684 87 10 of of ADP fnp-3684 87 11 smo smo PROPN fnp-3684 87 12 [ [ X fnp-3684 87 13 castellino castellino X fnp-3684 87 14 et et PROPN fnp-3684 87 15 al al PROPN fnp-3684 87 16 . . PROPN fnp-3684 87 17 2010 2010 NUM fnp-3684 87 18 ] ] PUNCT fnp-3684 87 19 , , PUNCT fnp-3684 87 20 additional additional ADJ fnp-3684 87 21 loss loss NOUN fnp-3684 87 22 of of ADP fnp-3684 87 23 pten pten NOUN fnp-3684 87 24 changed change VERB fnp-3684 87 25 the the DET fnp-3684 87 26 tumor tumor NOUN fnp-3684 87 27 histology histology NOUN fnp-3684 87 28 from from ADP fnp-3684 87 29 tumors tumor NOUN fnp-3684 87 30 resembling resemble VERB fnp-3684 87 31 classic classic ADJ fnp-3684 87 32 medulloblastomas medulloblastoma NOUN fnp-3684 87 33 to to ADP fnp-3684 87 34 tumors tumor NOUN fnp-3684 87 35 resembling resemble VERB fnp-3684 87 36 mben mben NOUN fnp-3684 87 37 . . PUNCT fnp-3684 88 1 using use VERB fnp-3684 88 2 similarity similarity NOUN fnp-3684 88 3 network network NOUN fnp-3684 88 4 fusion fusion NOUN fnp-3684 88 5 applied apply VERB fnp-3684 88 6 to to ADP fnp-3684 88 7 genome genome NOUN fnp-3684 88 8 - - PUNCT fnp-3684 88 9 wide wide ADJ fnp-3684 88 10 dna dna PROPN fnp-3684 88 11 methylation methylation NOUN fnp-3684 88 12 and and CCONJ fnp-3684 88 13 gene gene NOUN fnp-3684 88 14 expression expression NOUN fnp-3684 88 15 data datum NOUN fnp-3684 88 16 , , PUNCT fnp-3684 88 17 shh shh NOUN fnp-3684 88 18 - - PUNCT fnp-3684 88 19 medulloblastomas medulloblastoma NOUN fnp-3684 88 20 can can AUX fnp-3684 88 21 be be AUX fnp-3684 88 22 divided divide VERB fnp-3684 88 23 into into ADP fnp-3684 88 24 4 4 NUM fnp-3684 88 25 distinct distinct ADJ fnp-3684 88 26 subtypes subtype NOUN fnp-3684 89 1 [ [ X fnp-3684 89 2 cavalli cavalli X fnp-3684 89 3 et et PROPN fnp-3684 89 4 al al PROPN fnp-3684 89 5 . . PROPN fnp-3684 89 6 2017 2017 NUM fnp-3684 89 7 ] ] PUNCT fnp-3684 89 8 ; ; PUNCT fnp-3684 89 9 we we PRON fnp-3684 89 10 did do AUX fnp-3684 89 11 not not PART fnp-3684 89 12 perform perform VERB fnp-3684 89 13 this this DET fnp-3684 89 14 type type NOUN fnp-3684 89 15 of of ADP fnp-3684 89 16 analysis analysis NOUN fnp-3684 89 17 on on ADP fnp-3684 89 18 our our PRON fnp-3684 89 19 patient patient NOUN fnp-3684 89 20 ’s ’s PART fnp-3684 89 21 tumor tumor NOUN fnp-3684 89 22 and and CCONJ fnp-3684 89 23 based base VERB fnp-3684 89 24 on on ADP fnp-3684 89 25 the the DET fnp-3684 89 26 published publish VERB fnp-3684 89 27 data datum NOUN fnp-3684 89 28 , , PUNCT fnp-3684 89 29 neither neither CCONJ fnp-3684 89 30 did do VERB fnp-3684 89 31 the the DET fnp-3684 89 32 authors author NOUN fnp-3684 89 33 of of ADP fnp-3684 89 34 the the DET fnp-3684 89 35 two two NUM fnp-3684 89 36 other other ADJ fnp-3684 89 37 cases case NOUN fnp-3684 89 38 where where SCONJ fnp-3684 89 39 the the DET fnp-3684 89 40 tumor tumor NOUN fnp-3684 89 41 was be AUX fnp-3684 89 42 analyzed analyze VERB fnp-3684 89 43 ( ( PUNCT fnp-3684 89 44 cases case NOUN fnp-3684 89 45 3 3 NUM fnp-3684 89 46 and and CCONJ fnp-3684 89 47 4 4 NUM fnp-3684 89 48 ) ) PUNCT fnp-3684 89 49 . . PUNCT fnp-3684 90 1 brain brain NOUN fnp-3684 90 2 - - PUNCT fnp-3684 90 3 specific specific ADJ fnp-3684 90 4 suppression suppression NOUN fnp-3684 90 5 of of ADP fnp-3684 90 6 pten pten NOUN fnp-3684 90 7 in in ADP fnp-3684 90 8 mice mice NOUN fnp-3684 90 9 produces produce VERB fnp-3684 90 10 cerebellar cerebellar ADJ fnp-3684 90 11 lesions lesion NOUN fnp-3684 90 12 resembling resemble VERB fnp-3684 90 13 ldd ldd PROPN fnp-3684 90 14 , , PUNCT fnp-3684 90 15 but but CCONJ fnp-3684 90 16 not not PART fnp-3684 90 17 medulloblastomas medulloblastoma NOUN fnp-3684 90 18 [ [ X fnp-3684 90 19 backman backman NOUN fnp-3684 90 20 et et PROPN fnp-3684 90 21 al al PROPN fnp-3684 90 22 . . PROPN fnp-3684 90 23 2001 2001 NUM fnp-3684 90 24 ; ; PUNCT fnp-3684 90 25 kwon kwon VERB fnp-3684 90 26 et et PROPN fnp-3684 90 27 al al PROPN fnp-3684 90 28 . . PROPN fnp-3684 90 29 2001 2001 NUM fnp-3684 90 30 ] ] PUNCT fnp-3684 90 31 . . PUNCT fnp-3684 91 1 in in ADP fnp-3684 91 2 human human PROPN fnp-3684 91 3 shh shh PROPN fnp-3684 91 4 - - PUNCT fnp-3684 91 5 medulloblastomas medulloblastoma NOUN fnp-3684 91 6 , , PUNCT fnp-3684 91 7 loss loss NOUN fnp-3684 91 8 of of ADP fnp-3684 91 9 pten pten NOUN fnp-3684 91 10 almost almost ADV fnp-3684 91 11 never never ADV fnp-3684 91 12 occurs occur VERB fnp-3684 91 13 in in ADP fnp-3684 91 14 isolation isolation NOUN fnp-3684 91 15 . . PUNCT fnp-3684 92 1 in in ADP fnp-3684 92 2 a a DET fnp-3684 92 3 detailed detailed ADJ fnp-3684 92 4 analysis analysis NOUN fnp-3684 92 5 of of ADP fnp-3684 92 6 196 196 NUM fnp-3684 92 7 sporadic sporadic ADJ fnp-3684 92 8 shh shh NOUN fnp-3684 92 9 - - PUNCT fnp-3684 92 10 medulloblastomas medulloblastoma NOUN fnp-3684 93 1 [ [ X fnp-3684 93 2 skowron skowron X fnp-3684 93 3 et et PROPN fnp-3684 93 4 al al PROPN fnp-3684 93 5 . . PROPN fnp-3684 93 6 2021 2021 NUM fnp-3684 93 7 , , PUNCT fnp-3684 93 8 figure figure NOUN fnp-3684 93 9 2a 2a NUM fnp-3684 93 10 ] ] PUNCT fnp-3684 93 11 , , PUNCT fnp-3684 93 12 nine nine NUM fnp-3684 93 13 had have VERB fnp-3684 93 14 a a DET fnp-3684 93 15 deletion deletion NOUN fnp-3684 93 16 and/or and/or CCONJ fnp-3684 93 17 mutation mutation NOUN fnp-3684 93 18 of of ADP fnp-3684 93 19 pten pten NOUN fnp-3684 93 20 . . PUNCT fnp-3684 94 1 eight eight NUM fnp-3684 94 2 of of ADP fnp-3684 94 3 these these DET fnp-3684 94 4 tumors tumor NOUN fnp-3684 94 5 had have VERB fnp-3684 94 6 additional additional ADJ fnp-3684 94 7 , , PUNCT fnp-3684 94 8 often often ADV fnp-3684 94 9 multiple multiple ADJ fnp-3684 94 10 , , PUNCT fnp-3684 94 11 genetic genetic ADJ fnp-3684 94 12 alterations alteration NOUN fnp-3684 94 13 , , PUNCT fnp-3684 94 14 typically typically ADV fnp-3684 94 15 involving involve VERB fnp-3684 94 16 a a DET fnp-3684 94 17 gene gene NOUN fnp-3684 94 18 of of ADP fnp-3684 94 19 the the DET fnp-3684 94 20 shh shh NOUN fnp-3684 94 21 - - NOUN fnp-3684 94 22 pathway pathway NOUN fnp-3684 94 23 , , PUNCT fnp-3684 94 24 loss loss NOUN fnp-3684 94 25 of of ADP fnp-3684 94 26 9q 9q NOUN fnp-3684 94 27 ( ( PUNCT fnp-3684 94 28 which which PRON fnp-3684 94 29 deletes delete VERB fnp-3684 94 30 ptch1 ptch1 PROPN fnp-3684 94 31 ) ) PUNCT fnp-3684 94 32 , , PUNCT fnp-3684 94 33 loss loss NOUN fnp-3684 94 34 of of ADP fnp-3684 94 35 10q 10q NOUN fnp-3684 94 36 ( ( PUNCT fnp-3684 94 37 which which PRON fnp-3684 94 38 deletes delete VERB fnp-3684 94 39 pten pten VERB fnp-3684 94 40 and and CCONJ fnp-3684 94 41 sufu sufu NOUN fnp-3684 94 42 ) ) PUNCT fnp-3684 94 43 , , PUNCT fnp-3684 94 44 or or CCONJ fnp-3684 94 45 mutations mutation NOUN fnp-3684 94 46 and and CCONJ fnp-3684 94 47 fusions fusion NOUN fnp-3684 94 48 in in ADP fnp-3684 94 49 other other ADJ fnp-3684 94 50 genes gene NOUN fnp-3684 94 51 . . PUNCT fnp-3684 95 1 only only ADV fnp-3684 95 2 one one NUM fnp-3684 95 3 tumor tumor NOUN fnp-3684 95 4 had have VERB fnp-3684 95 5 an an DET fnp-3684 95 6 isolated isolated ADJ fnp-3684 95 7 variant variant NOUN fnp-3684 95 8 in in ADP fnp-3684 95 9 pten pten NOUN fnp-3684 95 10 , , PUNCT fnp-3684 95 11 but but CCONJ fnp-3684 95 12 the the DET fnp-3684 95 13 analyses analysis NOUN fnp-3684 95 14 may may AUX fnp-3684 95 15 not not PART fnp-3684 95 16 have have AUX fnp-3684 95 17 captured capture VERB fnp-3684 95 18 all all DET fnp-3684 95 19 possible possible ADJ fnp-3684 95 20 genetic genetic ADJ fnp-3684 95 21 alterations alteration NOUN fnp-3684 95 22 ( ( PUNCT fnp-3684 95 23 p. p. NOUN fnp-3684 95 24 skowron skowron NOUN fnp-3684 95 25 and and CCONJ fnp-3684 95 26 m. m. PROPN fnp-3684 95 27 taylor taylor PROPN fnp-3684 95 28 , , PUNCT fnp-3684 95 29 personal personal ADJ fnp-3684 95 30 communications communication NOUN fnp-3684 95 31 ) ) PUNCT fnp-3684 95 32 . . PUNCT fnp-3684 96 1 these these DET fnp-3684 96 2 findings finding NOUN fnp-3684 96 3 indicate indicate VERB fnp-3684 96 4 that that SCONJ fnp-3684 96 5 in in ADP fnp-3684 96 6 most most ADJ fnp-3684 96 7 instances instance NOUN fnp-3684 96 8 , , PUNCT fnp-3684 96 9 loss loss NOUN fnp-3684 96 10 of of ADP fnp-3684 96 11 pten pten NOUN fnp-3684 96 12 alone alone ADV fnp-3684 96 13 is be AUX fnp-3684 96 14 insufficient insufficient ADJ fnp-3684 96 15 to to PART fnp-3684 96 16 produce produce VERB fnp-3684 96 17 medulloblastomas medulloblastoma NOUN fnp-3684 96 18 . . PUNCT fnp-3684 97 1 shh shh VERB fnp-3684 97 2 - - PUNCT fnp-3684 97 3 activated activate VERB fnp-3684 97 4 medulloblastomas medulloblastoma NOUN fnp-3684 97 5 are be AUX fnp-3684 97 6 thought think VERB fnp-3684 97 7 to to PART fnp-3684 97 8 arise arise VERB fnp-3684 97 9 from from ADP fnp-3684 97 10 granule granule NOUN fnp-3684 97 11 cell cell NOUN fnp-3684 97 12 precursors precursor NOUN fnp-3684 97 13 that that PRON fnp-3684 97 14 form form VERB fnp-3684 97 15 the the DET fnp-3684 97 16 external external ADJ fnp-3684 97 17 granular granular ADJ fnp-3684 97 18 layer layer NOUN fnp-3684 97 19 ( ( PUNCT fnp-3684 97 20 egl egl NOUN fnp-3684 97 21 ) ) PUNCT fnp-3684 97 22 of of ADP fnp-3684 97 23 the the DET fnp-3684 97 24 cerebellar cerebellar ADJ fnp-3684 97 25 cortex cortex NOUN fnp-3684 97 26 ; ; PUNCT fnp-3684 97 27 their their PRON fnp-3684 97 28 proliferation proliferation NOUN fnp-3684 97 29 and and CCONJ fnp-3684 97 30 inward inward ADP fnp-3684 97 31 migration migration NOUN fnp-3684 97 32 to to PART fnp-3684 97 33 form form VERB fnp-3684 97 34 the the DET fnp-3684 97 35 internal internal ADJ fnp-3684 97 36 granule granule NOUN fnp-3684 97 37 cell cell NOUN fnp-3684 97 38 layer layer NOUN fnp-3684 97 39 is be AUX fnp-3684 97 40 driven drive VERB fnp-3684 97 41 by by ADP fnp-3684 97 42 purkinje purkinje PROPN fnp-3684 97 43 cell cell NOUN fnp-3684 97 44 - - PUNCT fnp-3684 97 45 derived derive VERB fnp-3684 97 46 shh shh NOUN fnp-3684 98 1 [ [ X fnp-3684 98 2 tamayo tamayo NOUN fnp-3684 98 3 - - PUNCT fnp-3684 98 4 orreo orreo PROPN fnp-3684 98 5 & & CCONJ fnp-3684 98 6 charron charron PROPN fnp-3684 98 7 2019 2019 NUM fnp-3684 98 8 ] ] PUNCT fnp-3684 98 9 . . PUNCT fnp-3684 99 1 in in ADP fnp-3684 99 2 humans human NOUN fnp-3684 99 3 , , PUNCT fnp-3684 99 4 the the DET fnp-3684 99 5 egl egl NOUN fnp-3684 99 6 persists persist VERB fnp-3684 99 7 after after ADP fnp-3684 99 8 birth birth NOUN fnp-3684 99 9 . . PUNCT fnp-3684 100 1 it it PRON fnp-3684 100 2 starts start VERB fnp-3684 100 3 to to PART fnp-3684 100 4 involute involute VERB fnp-3684 100 5 by by ADP fnp-3684 100 6 the the DET fnp-3684 100 7 2nd 2nd ADJ fnp-3684 100 8 to to ADP fnp-3684 100 9 4th 4th ADJ fnp-3684 100 10 post post ADJ fnp-3684 100 11 - - ADJ fnp-3684 100 12 natal natal ADJ fnp-3684 100 13 month month NOUN fnp-3684 100 14 and and CCONJ fnp-3684 100 15 usually usually ADV fnp-3684 100 16 has have AUX fnp-3684 100 17 disappeared disappear VERB fnp-3684 100 18 by by ADP fnp-3684 100 19 1 1 NUM fnp-3684 100 20 year year NOUN fnp-3684 100 21 , , PUNCT fnp-3684 100 22 although although SCONJ fnp-3684 100 23 rare rare ADJ fnp-3684 100 24 cases case NOUN fnp-3684 100 25 of of ADP fnp-3684 100 26 persistence persistence NOUN fnp-3684 100 27 until until ADP fnp-3684 100 28 2 2 NUM fnp-3684 100 29 years year NOUN fnp-3684 100 30 have have AUX fnp-3684 100 31 been be AUX fnp-3684 100 32 reported report VERB fnp-3684 100 33 [ [ PUNCT fnp-3684 100 34 friede friede ADJ fnp-3684 100 35 1989 1989 NUM fnp-3684 100 36 ] ] PUNCT fnp-3684 100 37 . . PUNCT fnp-3684 101 1 in in ADP fnp-3684 101 2 a a DET fnp-3684 101 3 patient patient NOUN fnp-3684 101 4 with with ADP fnp-3684 101 5 cs cs PROPN fnp-3684 101 6 , , PUNCT fnp-3684 101 7 all all DET fnp-3684 101 8 granule granule NOUN fnp-3684 101 9 cell cell NOUN fnp-3684 101 10 precursors precursor NOUN fnp-3684 101 11 in in ADP fnp-3684 101 12 the the DET fnp-3684 101 13 egl egl NOUN fnp-3684 101 14 are be AUX fnp-3684 101 15 haploinsufficient haploinsufficient ADJ fnp-3684 101 16 for for ADP fnp-3684 101 17 pten pten NOUN fnp-3684 101 18 , , PUNCT fnp-3684 101 19 but but CCONJ fnp-3684 101 20 this this PRON fnp-3684 101 21 is be AUX fnp-3684 101 22 not not PART fnp-3684 101 23 sufficient sufficient ADJ fnp-3684 101 24 to to PART fnp-3684 101 25 produce produce VERB fnp-3684 101 26 a a DET fnp-3684 101 27 medulloblastoma medulloblastoma NOUN fnp-3684 101 28 . . PUNCT fnp-3684 102 1 however however ADV fnp-3684 102 2 , , PUNCT fnp-3684 102 3 if if SCONJ fnp-3684 102 4 one one NUM fnp-3684 102 5 of of ADP fnp-3684 102 6 these these DET fnp-3684 102 7 cells cell NOUN fnp-3684 102 8 acquires acquire VERB fnp-3684 102 9 additional additional ADJ fnp-3684 102 10 alterations alteration NOUN fnp-3684 102 11 of of ADP fnp-3684 102 12 the the DET fnp-3684 102 13 type type NOUN fnp-3684 102 14 described describe VERB fnp-3684 102 15 by by ADP fnp-3684 102 16 skowron skowron PROPN fnp-3684 102 17 et et PROPN fnp-3684 102 18 al al PROPN fnp-3684 102 19 . . PUNCT fnp-3684 103 1 [ [ X fnp-3684 103 2 skowron skowron X fnp-3684 103 3 et et PROPN fnp-3684 103 4 al al PROPN fnp-3684 103 5 . . PROPN fnp-3684 103 6 2021 2021 NUM fnp-3684 103 7 ] ] PUNCT fnp-3684 103 8 , , PUNCT fnp-3684 103 9 it it PRON fnp-3684 103 10 can can AUX fnp-3684 103 11 give give VERB fnp-3684 103 12 rise rise NOUN fnp-3684 103 13 to to ADP fnp-3684 103 14 an an DET fnp-3684 103 15 shh shh NOUN fnp-3684 103 16 - - PUNCT fnp-3684 103 17 medulloblastoma medulloblastoma NOUN fnp-3684 103 18 . . PUNCT fnp-3684 104 1 this this PRON fnp-3684 104 2 would would AUX fnp-3684 104 3 be be AUX fnp-3684 104 4 a a DET fnp-3684 104 5 rare rare ADJ fnp-3684 104 6 event event NOUN fnp-3684 104 7 , , PUNCT fnp-3684 104 8 resulting result VERB fnp-3684 104 9 in in ADP fnp-3684 104 10 a a DET fnp-3684 104 11 low low ADJ fnp-3684 104 12 frequency frequency NOUN fnp-3684 104 13 of of ADP fnp-3684 104 14 medulloblastomas medulloblastoma NOUN fnp-3684 104 15 in in ADP fnp-3684 104 16 cs cs ADJ fnp-3684 104 17 patients patient NOUN fnp-3684 104 18 . . PUNCT fnp-3684 105 1 furthermore furthermore ADV fnp-3684 105 2 , , PUNCT fnp-3684 105 3 given give VERB fnp-3684 105 4 the the DET fnp-3684 105 5 rapid rapid ADJ fnp-3684 105 6 disappearance disappearance NOUN fnp-3684 105 7 of of ADP fnp-3684 105 8 the the DET fnp-3684 105 9 egl egl NOUN fnp-3684 105 10 after after ADP fnp-3684 105 11 birth birth NOUN fnp-3684 105 12 , , PUNCT fnp-3684 105 13 the the DET fnp-3684 105 14 " " PUNCT fnp-3684 105 15 window window NOUN fnp-3684 105 16 of of ADP fnp-3684 105 17 opportunity opportunity NOUN fnp-3684 105 18 " " PUNCT fnp-3684 105 19 for for ADP fnp-3684 105 20 the the DET fnp-3684 105 21 development development NOUN fnp-3684 105 22 of of ADP fnp-3684 105 23 a a DET fnp-3684 105 24 medulloblastoma medulloblastoma NOUN fnp-3684 105 25 in in ADP fnp-3684 105 26 cs cs PROPN fnp-3684 105 27 is be AUX fnp-3684 105 28 brief brief ADJ fnp-3684 105 29 and and CCONJ fnp-3684 105 30 explains explain VERB fnp-3684 105 31 why why SCONJ fnp-3684 105 32 they they PRON fnp-3684 105 33 only only ADV fnp-3684 105 34 occur occur VERB fnp-3684 105 35 in in ADP fnp-3684 105 36 infants infant NOUN fnp-3684 105 37 in in ADP fnp-3684 105 38 these these DET fnp-3684 105 39 patients patient NOUN fnp-3684 105 40 . . PUNCT fnp-3684 106 1 cs cs PROPN fnp-3684 106 2 may may AUX fnp-3684 106 3 be be AUX fnp-3684 106 4 under under ADV fnp-3684 106 5 - - PUNCT fnp-3684 106 6 recognized recognize VERB fnp-3684 106 7 in in ADP fnp-3684 106 8 medulloblastoma medulloblastoma ADJ fnp-3684 106 9 patients patient NOUN fnp-3684 106 10 . . PUNCT fnp-3684 107 1 while while SCONJ fnp-3684 107 2 90 90 NUM fnp-3684 107 3 % % NOUN fnp-3684 107 4 of of ADP fnp-3684 107 5 patients patient NOUN fnp-3684 107 6 with with ADP fnp-3684 107 7 cs cs PROPN fnp-3684 107 8 will will AUX fnp-3684 107 9 have have VERB fnp-3684 107 10 some some DET fnp-3684 107 11 features feature NOUN fnp-3684 107 12 of of ADP fnp-3684 107 13 cs cs PROPN fnp-3684 107 14 by by ADP fnp-3684 107 15 age age NOUN fnp-3684 107 16 20 20 NUM fnp-3684 107 17 [ [ X fnp-3684 107 18 yehia yehia PROPN fnp-3684 107 19 & & CCONJ fnp-3684 107 20 eng eng PROPN fnp-3684 107 21 2002/2021 2002/2021 NUM fnp-3684 107 22 ] ] PUNCT fnp-3684 107 23 , , PUNCT fnp-3684 107 24 infants infant NOUN fnp-3684 107 25 and and CCONJ fnp-3684 107 26 young young ADJ fnp-3684 107 27 children child NOUN fnp-3684 107 28 may may AUX fnp-3684 107 29 not not PART fnp-3684 107 30 show show VERB fnp-3684 107 31 some some PRON fnp-3684 107 32 of of ADP fnp-3684 107 33 the the DET fnp-3684 107 34 pathognomonic pathognomonic ADJ fnp-3684 107 35 features feature NOUN fnp-3684 107 36 , , PUNCT fnp-3684 107 37 such such ADJ fnp-3684 107 38 as as ADP fnp-3684 107 39 multiple multiple ADJ fnp-3684 107 40 facial facial ADJ fnp-3684 107 41 tricholemmomas tricholemmoma NOUN fnp-3684 107 42 , , PUNCT fnp-3684 107 43 and and CCONJ fnp-3684 107 44 present present ADJ fnp-3684 107 45 instead instead ADV fnp-3684 107 46 with with ADP fnp-3684 107 47 non non ADJ fnp-3684 107 48 - - ADJ fnp-3684 107 49 specific specific ADJ fnp-3684 107 50 findings finding NOUN fnp-3684 107 51 , , PUNCT fnp-3684 107 52 like like ADP fnp-3684 107 53 macrocrania macrocrania NOUN fnp-3684 107 54 , , PUNCT fnp-3684 107 55 autism autism NOUN fnp-3684 107 56 , , PUNCT fnp-3684 107 57 or or CCONJ fnp-3684 107 58 developmental developmental ADJ fnp-3684 107 59 delay delay NOUN fnp-3684 108 1 [ [ X fnp-3684 108 2 busa busa NOUN fnp-3684 108 3 et et PROPN fnp-3684 108 4 al al PROPN fnp-3684 108 5 . . PROPN fnp-3684 108 6 2015 2015 NUM fnp-3684 108 7 ] ] PUNCT fnp-3684 108 8 . . PUNCT fnp-3684 109 1 among among ADP fnp-3684 109 2 the the DET fnp-3684 109 3 5 5 NUM fnp-3684 109 4 patients patient NOUN fnp-3684 109 5 with with ADP fnp-3684 109 6 cs cs PROPN fnp-3684 109 7 and and CCONJ fnp-3684 109 8 medulloblastoma medulloblastoma ADJ fnp-3684 109 9 , , PUNCT fnp-3684 109 10 patient patient ADJ fnp-3684 109 11 1 1 NUM fnp-3684 109 12 had have VERB fnp-3684 109 13 oral oral ADJ fnp-3684 109 14 papillomas papilloma NOUN fnp-3684 109 15 at at ADP fnp-3684 109 16 the the DET fnp-3684 109 17 time time NOUN fnp-3684 109 18 of of ADP fnp-3684 109 19 his his PRON fnp-3684 109 20 medulloblastoma medulloblastoma ADJ fnp-3684 109 21 diagnosis diagnosis NOUN fnp-3684 109 22 [ [ X fnp-3684 109 23 bagan bagan X fnp-3684 109 24 et et PROPN fnp-3684 109 25 al al PROPN fnp-3684 109 26 . . PROPN fnp-3684 109 27 1989 1989 NUM fnp-3684 109 28 ] ] PUNCT fnp-3684 109 29 . . PUNCT fnp-3684 110 1 patient patient ADJ fnp-3684 110 2 2 2 NUM fnp-3684 110 3 developed develop VERB fnp-3684 110 4 gastro gastro ADJ fnp-3684 110 5 - - PUNCT fnp-3684 110 6 intestinal intestinal ADJ fnp-3684 110 7 polyps polyp NOUN fnp-3684 110 8 after after ADP fnp-3684 110 9 his his PRON fnp-3684 110 10 medulloblastoma medulloblastoma NOUN fnp-3684 110 11 and and CCONJ fnp-3684 110 12 sought seek VERB fnp-3684 110 13 medical medical ADJ fnp-3684 110 14 attention attention NOUN fnp-3684 110 15 for for ADP fnp-3684 110 16 oral oral ADJ fnp-3684 110 17 and and CCONJ fnp-3684 110 18 cutaneous cutaneous ADJ fnp-3684 110 19 lesions lesion NOUN fnp-3684 110 20 at at ADP fnp-3684 110 21 age age NOUN fnp-3684 110 22 14 14 NUM fnp-3684 110 23 , , PUNCT fnp-3684 110 24 at at ADP fnp-3684 110 25 which which DET fnp-3684 110 26 time time NOUN fnp-3684 110 27 the the DET fnp-3684 110 28 diagnosis diagnosis NOUN fnp-3684 110 29 of of ADP fnp-3684 110 30 cs cs PROPN fnp-3684 110 31 was be AUX fnp-3684 110 32 made make VERB fnp-3684 110 33 [ [ PUNCT fnp-3684 110 34 palatini palatini X fnp-3684 110 35 et et PROPN fnp-3684 110 36 al al PROPN fnp-3684 110 37 . . PROPN fnp-3684 110 38 2016 2016 NUM fnp-3684 110 39 ] ] PUNCT fnp-3684 110 40 . . PUNCT fnp-3684 111 1 no no DET fnp-3684 111 2 clinical clinical ADJ fnp-3684 111 3 details detail NOUN fnp-3684 111 4 are be AUX fnp-3684 111 5 available available ADJ fnp-3684 111 6 on on ADP fnp-3684 111 7 patient patient ADJ fnp-3684 111 8 3 3 NUM fnp-3684 112 1 [ [ X fnp-3684 112 2 waszak waszak X fnp-3684 112 3 et et PROPN fnp-3684 112 4 al al PROPN fnp-3684 112 5 . . PROPN fnp-3684 112 6 2018 2018 NUM fnp-3684 112 7 ] ] PUNCT fnp-3684 112 8 . . PUNCT fnp-3684 113 1 patient patient NOUN fnp-3684 113 2 4 4 NUM fnp-3684 113 3 showed show VERB fnp-3684 113 4 only only ADV fnp-3684 113 5 macrocrania macrocrania NOUN fnp-3684 113 6 at at ADP fnp-3684 113 7 the the DET fnp-3684 113 8 time time NOUN fnp-3684 113 9 her her PRON fnp-3684 113 10 medulloblastoma medulloblastoma NOUN fnp-3684 113 11 was be AUX fnp-3684 113 12 diagnosed diagnose VERB fnp-3684 114 1 [ [ X fnp-3684 114 2 tolonen tolonen X fnp-3684 114 3 et et PROPN fnp-3684 114 4 al al PROPN fnp-3684 114 5 . . PROPN fnp-3684 114 6 2020 2020 NUM fnp-3684 114 7 ] ] PUNCT fnp-3684 114 8 and and CCONJ fnp-3684 114 9 still still ADV fnp-3684 114 10 does do AUX fnp-3684 114 11 not not PART fnp-3684 114 12 have have VERB fnp-3684 114 13 other other ADJ fnp-3684 114 14 stigmata stigmata NOUN fnp-3684 114 15 of of ADP fnp-3684 114 16 cs cs PROPN fnp-3684 114 17 ( ( PUNCT fnp-3684 114 18 r. r. PROPN fnp-3684 114 19 niinimäki niinimäki PROPN fnp-3684 114 20 , , PUNCT fnp-3684 114 21 personal personal ADJ fnp-3684 114 22 communication communication NOUN fnp-3684 114 23 ) ) PUNCT fnp-3684 114 24 . . PUNCT fnp-3684 115 1 in in ADP fnp-3684 115 2 our our PRON fnp-3684 115 3 patient patient NOUN fnp-3684 115 4 , , PUNCT fnp-3684 115 5 sequencing sequence VERB fnp-3684 115 6 of of ADP fnp-3684 115 7 pten pten NOUN fnp-3684 115 8 was be AUX fnp-3684 115 9 only only ADV fnp-3684 115 10 undertaken undertake VERB fnp-3684 115 11 at at ADP fnp-3684 115 12 age age NOUN fnp-3684 115 13 9 9 NUM fnp-3684 115 14 , , PUNCT fnp-3684 115 15 after after ADP fnp-3684 115 16 the the DET fnp-3684 115 17 diagnosis diagnosis NOUN fnp-3684 115 18 of of ADP fnp-3684 115 19 the the DET fnp-3684 115 20 sclerotic sclerotic ADJ fnp-3684 115 21 fibroma fibroma NOUN fnp-3684 115 22 . . PUNCT fnp-3684 116 1 thus thus ADV fnp-3684 116 2 , , PUNCT fnp-3684 116 3 in in ADP fnp-3684 116 4 some some PRON fnp-3684 116 5 of of ADP fnp-3684 116 6 these these DET fnp-3684 116 7 young young ADJ fnp-3684 116 8 patients patient NOUN fnp-3684 116 9 , , PUNCT fnp-3684 116 10 the the DET fnp-3684 116 11 diagnosis diagnosis NOUN fnp-3684 116 12 of of ADP fnp-3684 116 13 cs cs PROPN fnp-3684 116 14 was be AUX fnp-3684 116 15 not not PART fnp-3684 116 16 clinically clinically ADV fnp-3684 116 17 obvious obvious ADJ fnp-3684 116 18 at at ADP fnp-3684 116 19 the the DET fnp-3684 116 20 time time NOUN fnp-3684 116 21 they they PRON fnp-3684 116 22 presented present VERB fnp-3684 116 23 with with ADP fnp-3684 116 24 a a DET fnp-3684 116 25 medulloblastoma medulloblastoma NOUN fnp-3684 116 26 ; ; PUNCT fnp-3684 116 27 we we PRON fnp-3684 116 28 therefore therefore ADV fnp-3684 116 29 suspect suspect VERB fnp-3684 116 30 that that SCONJ fnp-3684 116 31 cs cs PROPN fnp-3684 116 32 may may AUX fnp-3684 116 33 be be AUX fnp-3684 116 34 underdiagnosed underdiagnose VERB fnp-3684 116 35 in in ADP fnp-3684 116 36 medulloblastoma medulloblastoma ADJ fnp-3684 116 37 patients patient NOUN fnp-3684 116 38 . . PUNCT fnp-3684 117 1 a a DET fnp-3684 117 2 high high ADJ fnp-3684 117 3 prevalence prevalence NOUN fnp-3684 117 4 of of ADP fnp-3684 117 5 tumor tumor NOUN fnp-3684 117 6 predisposition predisposition NOUN fnp-3684 117 7 syndromes syndrome NOUN fnp-3684 117 8 in in ADP fnp-3684 117 9 children child NOUN fnp-3684 117 10 with with ADP fnp-3684 117 11 shh shh NOUN fnp-3684 117 12 - - PUNCT fnp-3684 117 13 medulloblastomas medulloblastoma NOUN fnp-3684 117 14 , , PUNCT fnp-3684 117 15 especially especially ADV fnp-3684 117 16 infants infant NOUN fnp-3684 117 17 , , PUNCT fnp-3684 117 18 has have AUX fnp-3684 117 19 long long ADV fnp-3684 117 20 been be AUX fnp-3684 117 21 known know VERB fnp-3684 117 22 . . PUNCT fnp-3684 118 1 for for ADP fnp-3684 118 2 instance instance NOUN fnp-3684 118 3 , , PUNCT fnp-3684 118 4 in in ADP fnp-3684 118 5 a a DET fnp-3684 118 6 single single ADJ fnp-3684 118 7 - - PUNCT fnp-3684 118 8 institution institution NOUN fnp-3684 118 9 series series NOUN fnp-3684 118 10 of of ADP fnp-3684 118 11 82 82 NUM fnp-3684 118 12 medulloblastoma medulloblastoma ADJ fnp-3684 118 13 patients patient NOUN fnp-3684 118 14 , , PUNCT fnp-3684 118 15 6 6 NUM fnp-3684 118 16 of of ADP fnp-3684 118 17 12 12 NUM fnp-3684 118 18 patients patient NOUN fnp-3684 118 19 with with ADP fnp-3684 118 20 an an DET fnp-3684 118 21 mben mben NOUN fnp-3684 118 22 had have VERB fnp-3684 118 23 a a DET fnp-3684 118 24 genetic genetic ADJ fnp-3684 118 25 syndrome syndrome NOUN fnp-3684 118 26 ( ( PUNCT fnp-3684 118 27 5 5 NUM fnp-3684 118 28 gorlin gorlin NOUN fnp-3684 118 29 , , PUNCT fnp-3684 118 30 1 1 NUM fnp-3684 118 31 fragile fragile ADJ fnp-3684 118 32 - - PUNCT fnp-3684 118 33 x x NOUN fnp-3684 118 34 ) ) PUNCT fnp-3684 118 35 ; ; PUNCT fnp-3684 118 36 5 5 NUM fnp-3684 118 37 of of ADP fnp-3684 118 38 these these DET fnp-3684 118 39 6 6 NUM fnp-3684 118 40 were be AUX fnp-3684 118 41 less less ADJ fnp-3684 118 42 than than ADP fnp-3684 118 43 24 24 NUM fnp-3684 118 44 months month NOUN fnp-3684 118 45 of of ADP fnp-3684 118 46 age age NOUN fnp-3684 118 47 [ [ X fnp-3684 118 48 garrè garrè NOUN fnp-3684 118 49 et et PROPN fnp-3684 118 50 al al PROPN fnp-3684 118 51 . . PROPN fnp-3684 118 52 2009 2009 NUM fnp-3684 118 53 ] ] PUNCT fnp-3684 118 54 . . PUNCT fnp-3684 119 1 in in ADP fnp-3684 119 2 the the DET fnp-3684 119 3 aforementioned aforementioned ADJ fnp-3684 119 4 series series NOUN fnp-3684 119 5 of of ADP fnp-3684 119 6 1022 1022 NUM fnp-3684 119 7 medulloblastomas medulloblastoma NOUN fnp-3684 119 8 , , PUNCT fnp-3684 119 9 predisposing predispose VERB fnp-3684 119 10 germline germline NOUN fnp-3684 119 11 variants variant NOUN fnp-3684 119 12 in in ADP fnp-3684 119 13 apc apc PROPN fnp-3684 119 14 , , PUNCT fnp-3684 119 15 brca2 brca2 PROPN fnp-3684 119 16 , , PUNCT fnp-3684 119 17 palpb2 palpb2 PROPN fnp-3684 119 18 , , PUNCT fnp-3684 119 19 ptch1 ptch1 PROPN fnp-3684 119 20 , , PUNCT fnp-3684 119 21 sufu sufu PROPN fnp-3684 119 22 , , PUNCT fnp-3684 119 23 and and CCONJ fnp-3684 119 24 tp53 tp53 PROPN fnp-3684 119 25 occurred occur VERB fnp-3684 119 26 in in ADP fnp-3684 119 27 6 6 NUM fnp-3684 119 28 % % NOUN fnp-3684 119 29 of of ADP fnp-3684 119 30 patients patient NOUN fnp-3684 119 31 overall overall ADJ fnp-3684 119 32 , , PUNCT fnp-3684 119 33 and and CCONJ fnp-3684 119 34 in in ADP fnp-3684 119 35 20 20 NUM fnp-3684 119 36 % % NOUN fnp-3684 119 37 of of ADP fnp-3684 119 38 those those PRON fnp-3684 119 39 with with ADP fnp-3684 119 40 shh shh NOUN fnp-3684 119 41 - - PUNCT fnp-3684 119 42 medulloblastomas medulloblastoma NOUN fnp-3684 120 1 [ [ X fnp-3684 120 2 waszak waszak X fnp-3684 120 3 et et PROPN fnp-3684 120 4 al al PROPN fnp-3684 120 5 . . PROPN fnp-3684 120 6 2018 2018 NUM fnp-3684 120 7 ] ] PUNCT fnp-3684 120 8 . . PUNCT fnp-3684 121 1 a a DET fnp-3684 121 2 further further ADJ fnp-3684 121 3 analysis analysis NOUN fnp-3684 121 4 by by ADP fnp-3684 121 5 the the DET fnp-3684 121 6 same same ADJ fnp-3684 121 7 group group NOUN fnp-3684 121 8 [ [ X fnp-3684 121 9 waszak waszak X fnp-3684 121 10 et et PROPN fnp-3684 121 11 al al PROPN fnp-3684 121 12 . . PROPN fnp-3684 121 13 2020 2020 NUM fnp-3684 121 14 ] ] PUNCT fnp-3684 121 15 identified identify VERB fnp-3684 121 16 in in ADP fnp-3684 121 17 addition addition NOUN fnp-3684 121 18 pathogenic pathogenic ADJ fnp-3684 121 19 germline germline NOUN fnp-3684 121 20 variants variant NOUN fnp-3684 121 21 in in ADP fnp-3684 121 22 elp1 elp1 PROPN fnp-3684 121 23 in in ADP fnp-3684 121 24 14 14 NUM fnp-3684 121 25 % % NOUN fnp-3684 121 26 of of ADP fnp-3684 121 27 pediatric pediatric ADJ fnp-3684 121 28 patients patient NOUN fnp-3684 121 29 with with ADP fnp-3684 121 30 shh shh NOUN fnp-3684 121 31 - - PUNCT fnp-3684 121 32 medulloblastomas medulloblastoma NOUN fnp-3684 121 33 ; ; PUNCT fnp-3684 121 34 all all PRON fnp-3684 121 35 in in ADV fnp-3684 121 36 all all PRON fnp-3684 121 37 , , PUNCT fnp-3684 121 38 77 77 NUM fnp-3684 121 39 of of ADP fnp-3684 121 40 202 202 NUM fnp-3684 121 41 children child NOUN fnp-3684 121 42 ( ( PUNCT fnp-3684 121 43 38 38 NUM fnp-3684 121 44 % % NOUN fnp-3684 121 45 ) ) PUNCT fnp-3684 121 46 with with ADP fnp-3684 121 47 an an DET fnp-3684 121 48 shh shh NOUN fnp-3684 121 49 - - PUNCT fnp-3684 121 50 medulloblastoma medulloblastoma NOUN fnp-3684 121 51 had have VERB fnp-3684 121 52 a a DET fnp-3684 121 53 predisposing predispose VERB fnp-3684 121 54 germline germline NOUN fnp-3684 121 55 variant variant NOUN fnp-3684 121 56 in in ADP fnp-3684 121 57 one one NUM fnp-3684 121 58 of of ADP fnp-3684 121 59 7 7 NUM fnp-3684 121 60 genes gene NOUN fnp-3684 121 61 . . PUNCT fnp-3684 122 1 here here ADV fnp-3684 122 2 , , PUNCT fnp-3684 122 3 we we PRON fnp-3684 122 4 present present VERB fnp-3684 122 5 evidence evidence NOUN fnp-3684 122 6 that that SCONJ fnp-3684 122 7 cs cs X fnp-3684 122 8 , , PUNCT fnp-3684 122 9 too too ADV fnp-3684 122 10 , , PUNCT fnp-3684 122 11 can can AUX fnp-3684 122 12 be be AUX fnp-3684 122 13 associated associate VERB fnp-3684 122 14 with with ADP fnp-3684 122 15 shh shh NOUN fnp-3684 122 16 - - PUNCT fnp-3684 122 17 medulloblastomas medulloblastoma NOUN fnp-3684 122 18 in in ADP fnp-3684 122 19 infants infant NOUN fnp-3684 122 20 . . PUNCT fnp-3684 123 1 therefore therefore ADV fnp-3684 123 2 , , PUNCT fnp-3684 123 3 pten pten VERB fnp-3684 123 4 should should AUX fnp-3684 123 5 be be AUX fnp-3684 123 6 analyzed analyze VERB fnp-3684 123 7 in in ADP fnp-3684 123 8 these these DET fnp-3684 123 9 patients patient NOUN fnp-3684 123 10 , , PUNCT fnp-3684 123 11 regardless regardless ADV fnp-3684 123 12 of of ADP fnp-3684 123 13 their their PRON fnp-3684 123 14 clinical clinical ADJ fnp-3684 123 15 phenotype phenotype NOUN fnp-3684 123 16 , , PUNCT fnp-3684 123 17 especially especially ADV fnp-3684 123 18 if if SCONJ fnp-3684 123 19 they they PRON fnp-3684 123 20 do do AUX fnp-3684 123 21 not not PART fnp-3684 123 22 carry carry VERB fnp-3684 123 23 pathogenic pathogenic ADJ fnp-3684 123 24 germline germline NOUN fnp-3684 123 25 variants variant NOUN fnp-3684 123 26 in in ADP fnp-3684 123 27 ptch1 ptch1 PROPN fnp-3684 123 28 or or CCONJ fnp-3684 123 29 sufu sufu PROPN fnp-3684 123 30 , , PUNCT fnp-3684 123 31 the the DET fnp-3684 123 32 most most ADV fnp-3684 123 33 commonly commonly ADV fnp-3684 123 34 altered alter VERB fnp-3684 123 35 predisposing predispose VERB fnp-3684 123 36 genes gene NOUN fnp-3684 123 37 in in ADP fnp-3684 123 38 infant infant NOUN fnp-3684 123 39 shh shh NOUN fnp-3684 123 40 - - PUNCT fnp-3684 123 41 medulloblastomas medulloblastoma NOUN fnp-3684 124 1 [ [ X fnp-3684 124 2 waszak waszak X fnp-3684 124 3 et et PROPN fnp-3684 124 4 al al PROPN fnp-3684 124 5 . . PROPN fnp-3684 124 6 2020 2020 NUM fnp-3684 124 7 ] ] PUNCT fnp-3684 124 8 . . PUNCT fnp-3684 125 1 whether whether SCONJ fnp-3684 125 2 cs cs PROPN fnp-3684 125 3 also also ADV fnp-3684 125 4 predisposes predispose VERB fnp-3684 125 5 to to ADP fnp-3684 125 6 other other ADJ fnp-3684 125 7 types type NOUN fnp-3684 125 8 of of ADP fnp-3684 125 9 medulloblastoma medulloblastoma NOUN fnp-3684 125 10 ( ( PUNCT fnp-3684 125 11 i.e. i.e. X fnp-3684 125 12 , , PUNCT fnp-3684 125 13 wnt wnt PROPN fnp-3684 125 14 , , PUNCT fnp-3684 125 15 group group NOUN fnp-3684 125 16 3 3 NUM fnp-3684 125 17 , , PUNCT fnp-3684 125 18 or or CCONJ fnp-3684 125 19 group group NOUN fnp-3684 125 20 4 4 NUM fnp-3684 125 21 ) ) PUNCT fnp-3684 125 22 remains remain VERB fnp-3684 125 23 to to PART fnp-3684 125 24 be be AUX fnp-3684 125 25 seen see VERB fnp-3684 125 26 . . PUNCT fnp-3684 126 1 in in ADP fnp-3684 126 2 addition addition NOUN fnp-3684 126 3 , , PUNCT fnp-3684 126 4 these these DET fnp-3684 126 5 cases case NOUN fnp-3684 126 6 show show VERB fnp-3684 126 7 that that SCONJ fnp-3684 126 8 cowden cowden PROPN fnp-3684 126 9 syndrome syndrome PROPN fnp-3684 126 10 has have VERB fnp-3684 126 11 a a DET fnp-3684 126 12 biphasic biphasic ADJ fnp-3684 126 13 brain brain NOUN fnp-3684 126 14 tumor tumor NOUN fnp-3684 126 15 distribution distribution NOUN fnp-3684 126 16 , , PUNCT fnp-3684 126 17 both both CCONJ fnp-3684 126 18 in in ADP fnp-3684 126 19 regards regard NOUN fnp-3684 126 20 to to ADP fnp-3684 126 21 the the DET fnp-3684 126 22 age age NOUN fnp-3684 126 23 of of ADP fnp-3684 126 24 onset onset NOUN fnp-3684 126 25 and and CCONJ fnp-3684 126 26 the the DET fnp-3684 126 27 tumor tumor NOUN fnp-3684 126 28 type type NOUN fnp-3684 126 29 : : PUNCT fnp-3684 126 30 a a DET fnp-3684 126 31 small small ADJ fnp-3684 126 32 number number NOUN fnp-3684 126 33 of of ADP fnp-3684 126 34 cowden cowden PROPN fnp-3684 126 35 patients patient NOUN fnp-3684 126 36 develop develop VERB fnp-3684 126 37 a a DET fnp-3684 126 38 medulloblastoma medulloblastoma NOUN fnp-3684 126 39 in in ADP fnp-3684 126 40 infancy infancy NOUN fnp-3684 126 41 while while SCONJ fnp-3684 126 42 many many ADJ fnp-3684 126 43 more more ADV fnp-3684 126 44 develop develop VERB fnp-3684 126 45 ldd ldd PROPN fnp-3684 126 46 in in ADP fnp-3684 126 47 adulthood adulthood NOUN fnp-3684 126 48 . . PUNCT fnp-3684 127 1 acknowledgements acknowledgement NOUN fnp-3684 127 2 we we PRON fnp-3684 127 3 thank thank VERB fnp-3684 127 4 j.v j.v PROPN fnp-3684 127 5 . . PROPN fnp-3684 127 6 bagan bagan PROPN fnp-3684 127 7 , , PUNCT fnp-3684 127 8 r. r. PROPN fnp-3684 127 9 niinimäki niinimäki PROPN fnp-3684 127 10 , , PUNCT fnp-3684 127 11 s. s. PROPN fnp-3684 127 12 pfister pfister PROPN fnp-3684 127 13 , , PUNCT fnp-3684 127 14 p. p. NOUN fnp-3684 127 15 skowron skowron NOUN fnp-3684 127 16 , , PUNCT fnp-3684 127 17 and and CCONJ fnp-3684 127 18 m.d m.d PROPN fnp-3684 127 19 . . PROPN fnp-3684 127 20 taylor taylor PROPN fnp-3684 127 21 for for ADP fnp-3684 127 22 kindly kindly ADV fnp-3684 127 23 providing provide VERB fnp-3684 127 24 additional additional ADJ fnp-3684 127 25 information information NOUN fnp-3684 127 26 on on ADP fnp-3684 127 27 previously previously ADV fnp-3684 127 28 published publish VERB fnp-3684 127 29 cases case NOUN fnp-3684 127 30 . . PUNCT fnp-3684 128 1 w. w. PROPN fnp-3684 128 2 foulkes foulkes PROPN fnp-3684 128 3 receives receive VERB fnp-3684 128 4 funding funding NOUN fnp-3684 128 5 from from ADP fnp-3684 128 6 the the DET fnp-3684 128 7 canadian canadian ADJ fnp-3684 128 8 institutes institutes PROPN fnp-3684 128 9 of of ADP fnp-3684 128 10 health health PROPN fnp-3684 128 11 research research NOUN fnp-3684 128 12 ( ( PUNCT fnp-3684 128 13 grant grant NOUN fnp-3684 128 14 fdn-148390 fdn-148390 NOUN fnp-3684 128 15 ) ) PUNCT fnp-3684 128 16 and and CCONJ fnp-3684 128 17 so so ADV fnp-3684 128 18 does do VERB fnp-3684 128 19 n. n. PROPN fnp-3684 128 20 jabado jabado PROPN fnp-3684 128 21 ( ( PUNCT fnp-3684 128 22 grant grant NOUN fnp-3684 128 23 mop-286756 mop-286756 NOUN fnp-3684 128 24 and and CCONJ fnp-3684 128 25 fdn-154307 fdn-154307 ADJ fnp-3684 128 26 ) ) PUNCT fnp-3684 128 27 . . PUNCT fnp-3684 129 1 references reference NOUN fnp-3684 129 2 backman backman PROPN fnp-3684 129 3 sa sa PROPN fnp-3684 129 4 et et PROPN fnp-3684 129 5 al al PROPN fnp-3684 129 6 . . PROPN fnp-3684 129 7 deletion deletion NOUN fnp-3684 129 8 of of ADP fnp-3684 129 9 pten pten NOUN fnp-3684 129 10 in in ADP fnp-3684 129 11 mouse mouse NOUN fnp-3684 129 12 brain brain NOUN fnp-3684 129 13 causes cause VERB fnp-3684 129 14 seizures seizure NOUN fnp-3684 129 15 , , PUNCT fnp-3684 129 16 ataxia ataxia NOUN fnp-3684 129 17 and and CCONJ fnp-3684 129 18 defects defect NOUN fnp-3684 129 19 in in ADP fnp-3684 129 20 soma soma NOUN fnp-3684 129 21 size size NOUN fnp-3684 129 22 resembling resemble VERB fnp-3684 129 23 lhermitte lhermitte NOUN fnp-3684 129 24 - - PUNCT fnp-3684 129 25 duclos duclo NOUN fnp-3684 129 26 disease disease NOUN fnp-3684 129 27 . . PUNCT fnp-3684 130 1 nat nat PROPN fnp-3684 130 2 genet genet PROPN fnp-3684 130 3 29 29 NUM fnp-3684 130 4 : : PUNCT fnp-3684 130 5 396–403 396–403 NUM fnp-3684 130 6 , , PUNCT fnp-3684 130 7 2001 2001 NUM fnp-3684 130 8 . . PUNCT fnp-3684 131 1 https://doi.org/10.1038/ng782 https://doi.org/10.1038/ng782 PROPN fnp-3684 131 2 bagan bagan PROPN fnp-3684 131 3 jv jv PROPN fnp-3684 131 4 et et PROPN fnp-3684 131 5 al al PROPN fnp-3684 131 6 . . PROPN fnp-3684 132 1 cowden cowden PROPN fnp-3684 132 2 syndrome syndrome PROPN fnp-3684 132 3 : : PUNCT fnp-3684 132 4 clinical clinical ADJ fnp-3684 132 5 and and CCONJ fnp-3684 132 6 pathological pathological ADJ fnp-3684 132 7 consideration consideration NOUN fnp-3684 132 8 in in ADP fnp-3684 132 9 two two NUM fnp-3684 132 10 new new ADJ fnp-3684 132 11 cases case NOUN fnp-3684 132 12 . . PUNCT fnp-3684 133 1 j j PROPN fnp-3684 133 2 oral oral ADJ fnp-3684 133 3 maxillofac maxillofac NOUN fnp-3684 133 4 surg surg NOUN fnp-3684 133 5 47 47 NUM fnp-3684 133 6 : : PUNCT fnp-3684 133 7 291–4 291–4 NOUN fnp-3684 133 8 , , PUNCT fnp-3684 133 9 1989 1989 NUM fnp-3684 133 10 . . PUNCT fnp-3684 134 1 https://doi.org/10.1016/0278-2391(89)90234-6 https://doi.org/10.1016/0278-2391(89)90234-6 PROPN fnp-3684 134 2 busa busa PROPN fnp-3684 134 3 t t PROPN fnp-3684 134 4 et et PROPN fnp-3684 134 5 al al PROPN fnp-3684 134 6 . . PROPN fnp-3684 135 1 clinical clinical ADJ fnp-3684 135 2 presentation presentation NOUN fnp-3684 135 3 of of ADP fnp-3684 135 4 pten pten ADJ fnp-3684 135 5 mutations mutation NOUN fnp-3684 135 6 in in ADP fnp-3684 135 7 childhood childhood NOUN fnp-3684 135 8 in in ADP fnp-3684 135 9 the the DET fnp-3684 135 10 absence absence NOUN fnp-3684 135 11 of of ADP fnp-3684 135 12 family family NOUN fnp-3684 135 13 history history NOUN fnp-3684 135 14 of of ADP fnp-3684 135 15 cowden cowden PROPN fnp-3684 135 16 syndrome syndrome PROPN fnp-3684 135 17 . . PUNCT fnp-3684 136 1 eur eur PROPN fnp-3684 136 2 j j PROPN fnp-3684 136 3 paediatr paediatr NOUN fnp-3684 136 4 neurol neurol NOUN fnp-3684 136 5 19 19 NUM fnp-3684 136 6 : : PUNCT fnp-3684 136 7 188–92 188–92 NUM fnp-3684 136 8 , , PUNCT fnp-3684 136 9 2015 2015 NUM fnp-3684 136 10 . . PUNCT fnp-3684 137 1 https://doi.org/10.1016/j.ejpn.2014.11.012 https://doi.org/10.1016/j.ejpn.2014.11.012 NOUN fnp-3684 137 2 castellino castellino PROPN fnp-3684 137 3 rc rc PROPN fnp-3684 137 4 et et PROPN fnp-3684 137 5 al al PROPN fnp-3684 137 6 . . PROPN fnp-3684 137 7 heterozygosity heterozygosity NOUN fnp-3684 137 8 for for ADP fnp-3684 137 9 pten pten NOUN fnp-3684 137 10 promotes promote VERB fnp-3684 137 11 tumorigenesis tumorigenesis NOUN fnp-3684 137 12 in in ADP fnp-3684 137 13 a a DET fnp-3684 137 14 mouse mouse NOUN fnp-3684 137 15 model model NOUN fnp-3684 137 16 of of ADP fnp-3684 137 17 medulloblastoma medulloblastoma NOUN fnp-3684 137 18 . . PUNCT fnp-3684 138 1 plos plos PROPN fnp-3684 138 2 one one NUM fnp-3684 138 3 5 5 NUM fnp-3684 138 4 : : PUNCT fnp-3684 138 5 e10849 e10849 NUM fnp-3684 138 6 , , PUNCT fnp-3684 138 7 2010 2010 NUM fnp-3684 138 8 . . PUNCT fnp-3684 139 1 https://doi.org/10.1371/journal.pone.0010849 https://doi.org/10.1371/journal.pone.0010849 PROPN fnp-3684 139 2 cavalli cavalli PROPN fnp-3684 139 3 fmg fmg PROPN fnp-3684 139 4 et et PROPN fnp-3684 139 5 al al PROPN fnp-3684 139 6 . . PROPN fnp-3684 140 1 intertumoral intertumoral ADJ fnp-3684 140 2 heterogeneity heterogeneity NOUN fnp-3684 140 3 within within ADP fnp-3684 140 4 medulloblastoma medulloblastoma ADJ fnp-3684 140 5 subgroups subgroup NOUN fnp-3684 140 6 . . PUNCT fnp-3684 141 1 cancer cancer NOUN fnp-3684 141 2 cell cell NOUN fnp-3684 141 3 31 31 NUM fnp-3684 141 4 : : PUNCT fnp-3684 141 5 737–54.e6 737–54.e6 NUM fnp-3684 141 6 , , PUNCT fnp-3684 141 7 2017 2017 NUM fnp-3684 141 8 . . PUNCT fnp-3684 142 1 https://doi.org/10.1016/j.ccell.2017.05.005 https://doi.org/10.1016/j.ccell.2017.05.005 VERB fnp-3684 142 2 cohen cohen PROPN fnp-3684 142 3 bh bh PROPN fnp-3684 142 4 et et PROPN fnp-3684 142 5 al al PROPN fnp-3684 142 6 . . PROPN fnp-3684 142 7 pilot pilot PROPN fnp-3684 142 8 study study NOUN fnp-3684 142 9 of of ADP fnp-3684 142 10 intensive intensive ADJ fnp-3684 142 11 chemotherapy chemotherapy NOUN fnp-3684 142 12 with with ADP fnp-3684 142 13 peripheral peripheral ADJ fnp-3684 142 14 hematopoietic hematopoietic ADJ fnp-3684 142 15 cell cell NOUN fnp-3684 142 16 support support NOUN fnp-3684 142 17 for for ADP fnp-3684 142 18 children child NOUN fnp-3684 142 19 less less ADJ fnp-3684 142 20 than than ADP fnp-3684 142 21 3 3 NUM fnp-3684 142 22 years year NOUN fnp-3684 142 23 of of ADP fnp-3684 142 24 age age NOUN fnp-3684 142 25 with with ADP fnp-3684 142 26 malignant malignant ADJ fnp-3684 142 27 brain brain NOUN fnp-3684 142 28 tumors tumor NOUN fnp-3684 142 29 , , PUNCT fnp-3684 142 30 the the DET fnp-3684 142 31 ccg-99703 ccg-99703 NOUN fnp-3684 142 32 phase phase NOUN fnp-3684 142 33 i i PROPN fnp-3684 142 34 / / SYM fnp-3684 142 35 ii ii PROPN fnp-3684 142 36 study study NOUN fnp-3684 142 37 . . PUNCT fnp-3684 143 1 a a DET fnp-3684 143 2 report report NOUN fnp-3684 143 3 from from ADP fnp-3684 143 4 the the DET fnp-3684 143 5 children child NOUN fnp-3684 143 6 's 's PART fnp-3684 143 7 oncology oncology NOUN fnp-3684 143 8 group group NOUN fnp-3684 143 9 . . PUNCT fnp-3684 144 1 pediatr pediatr PROPN fnp-3684 144 2 neurol neurol NOUN fnp-3684 144 3 53 53 NUM fnp-3684 144 4 : : PUNCT fnp-3684 144 5 31–46 31–46 NUM fnp-3684 144 6 , , PUNCT fnp-3684 144 7 2015 2015 NUM fnp-3684 144 8 . . PUNCT fnp-3684 145 1 https://doi.org/10.1016/j.pediatrneurol.2015.03.019 https://doi.org/10.1016/j.pediatrneurol.2015.03.019 VERB fnp-3684 145 2 eng eng PROPN fnp-3684 145 3 c. c. PROPN fnp-3684 145 4 will will AUX fnp-3684 145 5 the the DET fnp-3684 145 6 real real PROPN fnp-3684 145 7 cowden cowden PROPN fnp-3684 145 8 syndrome syndrome PROPN fnp-3684 145 9 please please INTJ fnp-3684 145 10 stand stand VERB fnp-3684 145 11 up up ADP fnp-3684 145 12 : : PUNCT fnp-3684 145 13 revised revise VERB fnp-3684 145 14 diagnostic diagnostic ADJ fnp-3684 145 15 criteria criterion NOUN fnp-3684 145 16 . . PUNCT fnp-3684 146 1 j j PROPN fnp-3684 146 2 med med PROPN fnp-3684 146 3 genet genet PROPN fnp-3684 146 4 . . PUNCT fnp-3684 147 1 37 37 NUM fnp-3684 147 2 : : PUNCT fnp-3684 147 3 828–30 828–30 NUM fnp-3684 147 4 , , PUNCT fnp-3684 147 5 2000 2000 NUM fnp-3684 147 6 . . PUNCT fnp-3684 148 1 https://doi.org/10.1136/jmg.37.11.828 https://doi.org/10.1136/jmg.37.11.828 PROPN fnp-3684 148 2 friede friede PROPN fnp-3684 148 3 rl rl PROPN fnp-3684 148 4 . . PUNCT fnp-3684 148 5 developmental developmental ADJ fnp-3684 148 6 neuropathology neuropathology NOUN fnp-3684 148 7 . . PUNCT fnp-3684 149 1 2nd 2nd ADJ fnp-3684 149 2 ed ed NOUN fnp-3684 149 3 , , PUNCT fnp-3684 149 4 springer springer NOUN fnp-3684 149 5 , , PUNCT fnp-3684 149 6 1989 1989 NUM fnp-3684 149 7 , , PUNCT fnp-3684 149 8 p. p. NOUN fnp-3684 149 9 15–6 15–6 PROPN fnp-3684 149 10 . . PUNCT fnp-3684 150 1 gandhi gandhi PROPN fnp-3684 151 1 d d PROPN fnp-3684 151 2 et et PROPN fnp-3684 151 3 al al PROPN fnp-3684 151 4 . . PUNCT fnp-3684 152 1 intracranial intracranial ADJ fnp-3684 152 2 dural dural ADJ fnp-3684 152 3 arteriovenous arteriovenous ADJ fnp-3684 152 4 fistulas fistula NOUN fnp-3684 152 5 : : PUNCT fnp-3684 152 6 classification classification NOUN fnp-3684 152 7 , , PUNCT fnp-3684 152 8 imaging imaging NOUN fnp-3684 152 9 findings finding NOUN fnp-3684 152 10 , , PUNCT fnp-3684 152 11 and and CCONJ fnp-3684 152 12 treatment treatment NOUN fnp-3684 152 13 . . PUNCT fnp-3684 153 1 ajnr ajnr PROPN fnp-3684 153 2 am be AUX fnp-3684 153 3 j j PROPN fnp-3684 153 4 neuroradiol neuroradiol PROPN fnp-3684 153 5 . . PUNCT fnp-3684 154 1 33 33 NUM fnp-3684 154 2 : : PUNCT fnp-3684 154 3 1007–13 1007–13 NUM fnp-3684 154 4 , , PUNCT fnp-3684 154 5 2012 2012 NUM fnp-3684 154 6 . . PUNCT fnp-3684 155 1 https://doi.org/10.3174/ajnr.a2798 https://doi.org/10.3174/ajnr.a2798 VERB fnp-3684 155 2 garrè garrè NOUN fnp-3684 155 3 ml ml NOUN fnp-3684 156 1 et et PROPN fnp-3684 156 2 al al PROPN fnp-3684 156 3 . . PROPN fnp-3684 156 4 medulloblastoma medulloblastoma PROPN fnp-3684 156 5 variants variant NOUN fnp-3684 156 6 : : PUNCT fnp-3684 156 7 age age NOUN fnp-3684 156 8 - - PUNCT fnp-3684 156 9 dependent dependent ADJ fnp-3684 156 10 occurrence occurrence NOUN fnp-3684 156 11 and and CCONJ fnp-3684 156 12 relation relation NOUN fnp-3684 156 13 to to ADP fnp-3684 156 14 gorlin gorlin PROPN fnp-3684 156 15 syndrome syndrome PROPN fnp-3684 156 16 — — PUNCT fnp-3684 156 17 a a DET fnp-3684 156 18 new new ADJ fnp-3684 156 19 clinical clinical ADJ fnp-3684 156 20 perspective perspective NOUN fnp-3684 156 21 . . PUNCT fnp-3684 157 1 clin clin PROPN fnp-3684 157 2 cancer cancer NOUN fnp-3684 157 3 res re VERB fnp-3684 157 4 15 15 NUM fnp-3684 157 5 : : PUNCT fnp-3684 157 6 2463–71 2463–71 NUM fnp-3684 157 7 , , PUNCT fnp-3684 157 8 2009 2009 NUM fnp-3684 157 9 . . PUNCT fnp-3684 158 1 https://doi.org/10.1158/1078-0432.ccr-08-2023 https://doi.org/10.1158/1078-0432.ccr-08-2023 PUNCT fnp-3684 158 2 goschzik goschzik NOUN fnp-3684 158 3 t t PROPN fnp-3684 158 4 et et PROPN fnp-3684 158 5 al al PROPN fnp-3684 158 6 . . PROPN fnp-3684 158 7 medulloblastoma medulloblastoma PROPN fnp-3684 158 8 in in ADP fnp-3684 158 9 adults adult NOUN fnp-3684 158 10 : : PUNCT fnp-3684 158 11 cytogenetic cytogenetic ADJ fnp-3684 158 12 phenotypes phenotype NOUN fnp-3684 158 13 identify identify VERB fnp-3684 158 14 prognostic prognostic ADJ fnp-3684 158 15 subgroups subgroup NOUN fnp-3684 158 16 . . PUNCT fnp-3684 159 1 j j PROPN fnp-3684 159 2 neuropathol neuropathol PROPN fnp-3684 159 3 exp exp PROPN fnp-3684 159 4 neurol neurol PROPN fnp-3684 159 5 80 80 NUM fnp-3684 159 6 : : PUNCT fnp-3684 159 7 419–30 419–30 NUM fnp-3684 159 8 , , PUNCT fnp-3684 159 9 2021 2021 NUM fnp-3684 159 10 . . PUNCT fnp-3684 160 1 https://doi.org/10.1093/jnen/nlab020 https://doi.org/10.1093/jnen/nlab020 NOUN fnp-3684 160 2 gröbner gröbner NOUN fnp-3684 160 3 sn sn PROPN fnp-3684 160 4 et et PROPN fnp-3684 160 5 al al PROPN fnp-3684 160 6 . . PUNCT fnp-3684 161 1 the the DET fnp-3684 161 2 landscape landscape NOUN fnp-3684 161 3 of of ADP fnp-3684 161 4 genomic genomic ADJ fnp-3684 161 5 alterations alteration NOUN fnp-3684 161 6 across across ADP fnp-3684 161 7 childhood childhood NOUN fnp-3684 161 8 cancers cancer NOUN fnp-3684 161 9 . . PUNCT fnp-3684 162 1 nature nature NOUN fnp-3684 162 2 555 555 NUM fnp-3684 162 3 : : PUNCT fnp-3684 162 4 321–27 321–27 NUM fnp-3684 162 5 , , PUNCT fnp-3684 162 6 2018 2018 NUM fnp-3684 162 7 . . PUNCT fnp-3684 163 1 https://doi.org/10.1038/nature25480 https://doi.org/10.1038/nature25480 AUX fnp-3684 163 2 kieselova kieselova VERB fnp-3684 163 3 k k PROPN fnp-3684 163 4 et et PROPN fnp-3684 163 5 al al PROPN fnp-3684 163 6 . . PROPN fnp-3684 163 7 multiple multiple ADJ fnp-3684 163 8 sclerotic sclerotic ADJ fnp-3684 163 9 fibromas fibroma NOUN fnp-3684 163 10 of of ADP fnp-3684 163 11 the the DET fnp-3684 163 12 skin skin NOUN fnp-3684 163 13 : : PUNCT fnp-3684 163 14 an an DET fnp-3684 163 15 important important ADJ fnp-3684 163 16 clue clue NOUN fnp-3684 163 17 for for ADP fnp-3684 163 18 the the DET fnp-3684 163 19 diagnosis diagnosis NOUN fnp-3684 163 20 of of ADP fnp-3684 163 21 cowden cowden PROPN fnp-3684 163 22 syndrome syndrome PROPN fnp-3684 163 23 . . PUNCT fnp-3684 164 1 bmj bmj PROPN fnp-3684 164 2 case case NOUN fnp-3684 164 3 rep rep PROPN fnp-3684 164 4 2017 2017 NUM fnp-3684 164 5 . . PUNCT fnp-3684 165 1 https://doi.org/10.1136/bcr-2017-221695 https://doi.org/10.1136/bcr-2017-221695 PROPN fnp-3684 165 2 kwon kwon VERB fnp-3684 165 3 ch ch PROPN fnp-3684 165 4 et et PROPN fnp-3684 165 5 al al PROPN fnp-3684 165 6 . . PROPN fnp-3684 165 7 pten pten PROPN fnp-3684 165 8 regulates regulate VERB fnp-3684 165 9 neuronal neuronal ADJ fnp-3684 165 10 soma soma NOUN fnp-3684 165 11 size size NOUN fnp-3684 165 12 : : PUNCT fnp-3684 165 13 a a DET fnp-3684 165 14 mouse mouse NOUN fnp-3684 165 15 model model NOUN fnp-3684 165 16 of of ADP fnp-3684 165 17 lhermitte lhermitte NOUN fnp-3684 165 18 - - PUNCT fnp-3684 165 19 duclos duclo NOUN fnp-3684 165 20 disease disease NOUN fnp-3684 165 21 . . PUNCT fnp-3684 166 1 nat nat PROPN fnp-3684 166 2 genet genet PROPN fnp-3684 166 3 29 29 NUM fnp-3684 166 4 : : PUNCT fnp-3684 166 5 404–11 404–11 NUM fnp-3684 166 6 , , PUNCT fnp-3684 166 7 2001 2001 NUM fnp-3684 166 8 . . PUNCT fnp-3684 167 1 https://doi.org/10.1038/ng781 https://doi.org/10.1038/ng781 PROPN fnp-3684 167 2 metcalfe metcalfe PROPN fnp-3684 167 3 c c PROPN fnp-3684 167 4 et et PROPN fnp-3684 167 5 al al PROPN fnp-3684 167 6 . . PROPN fnp-3684 167 7 pten pten PROPN fnp-3684 167 8 loss loss NOUN fnp-3684 167 9 mitigates mitigate VERB fnp-3684 167 10 the the DET fnp-3684 167 11 response response NOUN fnp-3684 167 12 of of ADP fnp-3684 167 13 medulloblastoma medulloblastoma NOUN fnp-3684 167 14 to to ADP fnp-3684 167 15 hedgehog hedgehog NOUN fnp-3684 167 16 pathway pathway NOUN fnp-3684 167 17 inhibition inhibition NOUN fnp-3684 167 18 . . PUNCT fnp-3684 168 1 cancer cancer NOUN fnp-3684 168 2 res re VERB fnp-3684 168 3 73 73 NUM fnp-3684 168 4 : : PUNCT fnp-3684 168 5 7034–42 7034–42 NUM fnp-3684 168 6 , , PUNCT fnp-3684 168 7 2013 2013 NUM fnp-3684 168 8 . . PUNCT fnp-3684 168 9 https://doi.org/10.1158/0008-5472.can-13-1222 https://doi.org/10.1158/0008-5472.can-13-1222 PUNCT fnp-3684 169 1 northcott northcott PROPN fnp-3684 169 2 pa pa PROPN fnp-3684 169 3 et et PROPN fnp-3684 169 4 al al PROPN fnp-3684 169 5 . . PROPN fnp-3684 169 6 subgroup subgroup PROPN fnp-3684 169 7 - - PUNCT fnp-3684 169 8 specific specific ADJ fnp-3684 169 9 structural structural ADJ fnp-3684 169 10 variation variation NOUN fnp-3684 169 11 across across ADP fnp-3684 169 12 1,000 1,000 NUM fnp-3684 169 13 medulloblastoma medulloblastoma NOUN fnp-3684 169 14 genomes genome NOUN fnp-3684 169 15 . . PUNCT fnp-3684 170 1 nature nature NOUN fnp-3684 170 2 488 488 NUM fnp-3684 170 3 : : PUNCT fnp-3684 170 4 49–56 49–56 NUM fnp-3684 170 5 , , PUNCT fnp-3684 170 6 2012 2012 NUM fnp-3684 170 7 . . PUNCT fnp-3684 171 1 https://doi.org/10.1038/nature11327 https://doi.org/10.1038/nature11327 PROPN fnp-3684 171 2 prats prats PROPN fnp-3684 171 3 - - PUNCT fnp-3684 171 4 sánchez sánchez NOUN fnp-3684 171 5 la la PROPN fnp-3684 171 6 et et PROPN fnp-3684 171 7 al al PROPN fnp-3684 171 8 . . PUNCT fnp-3684 171 9 multiple multiple ADJ fnp-3684 171 10 intracranial intracranial ADJ fnp-3684 171 11 arteriovenous arteriovenous ADJ fnp-3684 171 12 fistulas fistula NOUN fnp-3684 171 13 in in ADP fnp-3684 171 14 cowden cowden PROPN fnp-3684 171 15 syndrome syndrome PROPN fnp-3684 171 16 . . PUNCT fnp-3684 172 1 j j PROPN fnp-3684 172 2 stroke stroke PROPN fnp-3684 172 3 cerebrovasc cerebrovasc PROPN fnp-3684 172 4 dis dis PROPN fnp-3684 172 5 25 25 NUM fnp-3684 172 6 : : PUNCT fnp-3684 172 7 e93–4 e93–4 NOUN fnp-3684 172 8 , , PUNCT fnp-3684 172 9 2016 2016 NUM fnp-3684 172 10 . . PUNCT fnp-3684 173 1 https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.03.048 https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.03.048 PROPN fnp-3684 173 2 riegert riegert PROPN fnp-3684 173 3 - - PUNCT fnp-3684 173 4 johnson johnson PROPN fnp-3684 173 5 dl dl PROPN fnp-3684 173 6 et et PROPN fnp-3684 173 7 al al PROPN fnp-3684 173 8 . . PUNCT fnp-3684 173 9 cancer cancer NOUN fnp-3684 173 10 and and CCONJ fnp-3684 173 11 lhermitte lhermitte NOUN fnp-3684 173 12 - - PUNCT fnp-3684 173 13 duclos duclo NOUN fnp-3684 173 14 disease disease NOUN fnp-3684 173 15 are be AUX fnp-3684 173 16 common common ADJ fnp-3684 173 17 in in ADP fnp-3684 173 18 cowden cowden PROPN fnp-3684 173 19 syndrome syndrome PROPN fnp-3684 173 20 patients patient NOUN fnp-3684 173 21 . . PUNCT fnp-3684 174 1 hered here VERB fnp-3684 174 2 cancer cancer NOUN fnp-3684 174 3 clin clin PROPN fnp-3684 174 4 pract pract PROPN fnp-3684 174 5 8 8 NUM fnp-3684 174 6 : : SYM fnp-3684 174 7 6 6 NUM fnp-3684 174 8 , , PUNCT fnp-3684 174 9 2010 2010 NUM fnp-3684 174 10 . . PUNCT fnp-3684 175 1 https://doi.org/10.1186/1897-4287-8-6 https://doi.org/10.1186/1897-4287-8-6 VERB fnp-3684 175 2 skowron skowron ADJ fnp-3684 175 3 p p PROPN fnp-3684 175 4 et et PROPN fnp-3684 175 5 al al PROPN fnp-3684 175 6 . . PUNCT fnp-3684 176 1 the the DET fnp-3684 176 2 transcriptional transcriptional ADJ fnp-3684 176 3 landscape landscape NOUN fnp-3684 176 4 of of ADP fnp-3684 176 5 shh shh INTJ fnp-3684 176 6 medulloblastoma medulloblastoma PROPN fnp-3684 176 7 . . PUNCT fnp-3684 177 1 nat nat PROPN fnp-3684 177 2 commun commun PROPN fnp-3684 177 3 12 12 NUM fnp-3684 177 4 : : SYM fnp-3684 177 5 1749 1749 NUM fnp-3684 177 6 , , PUNCT fnp-3684 177 7 2021 2021 NUM fnp-3684 177 8 . . PUNCT fnp-3684 178 1 https://doi.org/10.1038/s41467-021-21883-0 https://doi.org/10.1038/s41467-021-21883-0 PROPN fnp-3684 178 2 tamayo tamayo PROPN fnp-3684 178 3 - - PUNCT fnp-3684 178 4 orrego orrego NOUN fnp-3684 178 5 l l NOUN fnp-3684 178 6 , , PUNCT fnp-3684 178 7 charron charron PROPN fnp-3684 178 8 f. f. PROPN fnp-3684 178 9 recent recent ADJ fnp-3684 178 10 advances advance NOUN fnp-3684 178 11 in in ADP fnp-3684 178 12 shh shh INTJ fnp-3684 178 13 medulloblastoma medulloblastoma ADJ fnp-3684 178 14 progression progression NOUN fnp-3684 178 15 : : PUNCT fnp-3684 178 16 tumor tumor NOUN fnp-3684 178 17 suppressor suppressor NOUN fnp-3684 178 18 mechanisms mechanism NOUN fnp-3684 178 19 and and CCONJ fnp-3684 178 20 the the DET fnp-3684 178 21 tumor tumor NOUN fnp-3684 178 22 microenvironment microenvironment NOUN fnp-3684 178 23 . . PUNCT fnp-3684 179 1 f1000res f1000re VERB fnp-3684 179 2 8 8 NUM fnp-3684 179 3 : : SYM fnp-3684 179 4 f1000 f1000 NUM fnp-3684 179 5 faculty faculty NOUN fnp-3684 179 6 rev-1823 rev-1823 NOUN fnp-3684 179 7 , , PUNCT fnp-3684 179 8 2019 2019 NUM fnp-3684 179 9 . . PUNCT fnp-3684 180 1 https://doi.org/10.12688/f1000research.20013.1 https://doi.org/10.12688/f1000research.20013.1 PROPN fnp-3684 180 2 tan tan PROPN fnp-3684 180 3 mh mh PROPN fnp-3684 180 4 et et PROPN fnp-3684 180 5 al al PROPN fnp-3684 180 6 . . PROPN fnp-3684 180 7 lifetime lifetime NOUN fnp-3684 180 8 cancer cancer NOUN fnp-3684 180 9 risks risk NOUN fnp-3684 180 10 in in ADP fnp-3684 180 11 individuals individual NOUN fnp-3684 180 12 with with ADP fnp-3684 180 13 germline germline NOUN fnp-3684 180 14 pten pten VERB fnp-3684 180 15 mutations mutation NOUN fnp-3684 180 16 . . PUNCT fnp-3684 181 1 clin clin PROPN fnp-3684 181 2 cancer cancer NOUN fnp-3684 181 3 res re VERB fnp-3684 181 4 18 18 NUM fnp-3684 181 5 : : SYM fnp-3684 181 6 400–7 400–7 NUM fnp-3684 181 7 , , PUNCT fnp-3684 181 8 2012 2012 NUM fnp-3684 181 9 . . PUNCT fnp-3684 182 1 https://doi.org/10.1158/1078-0432.ccr-11-2283 https://doi.org/10.1158/1078-0432.ccr-11-2283 PROPN fnp-3684 182 2 tolonen tolonen NOUN fnp-3684 182 3 jp jp INTJ fnp-3684 182 4 et et PROPN fnp-3684 182 5 al al PROPN fnp-3684 182 6 . . PROPN fnp-3684 182 7 medulloblastoma medulloblastoma PROPN fnp-3684 182 8 , , PUNCT fnp-3684 182 9 macrocephaly macrocephaly PROPN fnp-3684 182 10 , , PUNCT fnp-3684 182 11 and and CCONJ fnp-3684 182 12 a a DET fnp-3684 182 13 pathogenic pathogenic ADJ fnp-3684 182 14 germline germline NOUN fnp-3684 182 15 pten pten VERB fnp-3684 182 16 variant variant NOUN fnp-3684 182 17 : : PUNCT fnp-3684 182 18 cause cause NOUN fnp-3684 182 19 or or CCONJ fnp-3684 182 20 coincidence coincidence NOUN fnp-3684 182 21 ? ? PUNCT fnp-3684 183 1 molec molec PROPN fnp-3684 183 2 genet genet PROPN fnp-3684 183 3 genomic genomic PROPN fnp-3684 183 4 med me VERB fnp-3684 183 5 8 8 NUM fnp-3684 183 6 : : PUNCT fnp-3684 183 7 e1302 e1302 PROPN fnp-3684 183 8 , , PUNCT fnp-3684 183 9 2020 2020 NUM fnp-3684 183 10 . . PUNCT fnp-3684 184 1 https://doi.org/10.1002/mgg3.1302 https://doi.org/10.1002/mgg3.1302 X fnp-3684 184 2 waszak waszak NOUN fnp-3684 185 1 sm sm INTJ fnp-3684 185 2 et et PROPN fnp-3684 185 3 al al PROPN fnp-3684 185 4 . . PROPN fnp-3684 185 5 spectrum spectrum PROPN fnp-3684 185 6 and and CCONJ fnp-3684 185 7 prevalence prevalence NOUN fnp-3684 185 8 of of ADP fnp-3684 185 9 genetic genetic ADJ fnp-3684 185 10 predisposition predisposition NOUN fnp-3684 185 11 in in ADP fnp-3684 185 12 medulloblastoma medulloblastoma NOUN fnp-3684 185 13 : : PUNCT fnp-3684 185 14 a a DET fnp-3684 185 15 retrospective retrospective ADJ fnp-3684 185 16 genetic genetic ADJ fnp-3684 185 17 study study NOUN fnp-3684 185 18 and and CCONJ fnp-3684 185 19 prospective prospective ADJ fnp-3684 185 20 validation validation NOUN fnp-3684 185 21 in in ADP fnp-3684 185 22 a a DET fnp-3684 185 23 clinical clinical ADJ fnp-3684 185 24 trial trial NOUN fnp-3684 185 25 cohort cohort NOUN fnp-3684 185 26 . . PUNCT fnp-3684 186 1 lancet lancet PROPN fnp-3684 186 2 . . PUNCT fnp-3684 187 1 oncol oncol ADJ fnp-3684 187 2 19 19 NUM fnp-3684 187 3 : : PUNCT fnp-3684 187 4 785–98 785–98 NUM fnp-3684 187 5 , , PUNCT fnp-3684 187 6 2018 2018 NUM fnp-3684 187 7 . . PUNCT fnp-3684 188 1 https://doi.org/10.1016/s1470-2045(18)30242-0 https://doi.org/10.1016/s1470-2045(18)30242-0 ADV fnp-3684 188 2 waszak waszak NOUN fnp-3684 188 3 sm sm INTJ fnp-3684 188 4 et et PROPN fnp-3684 188 5 al al PROPN fnp-3684 188 6 . . PROPN fnp-3684 189 1 germline germline PROPN fnp-3684 189 2 elongator elongator NOUN fnp-3684 189 3 mutations mutation NOUN fnp-3684 189 4 in in ADP fnp-3684 189 5 sonic sonic ADJ fnp-3684 189 6 hedgehog hedgehog ADJ fnp-3684 189 7 medulloblastoma medulloblastoma NOUN fnp-3684 189 8 . . PUNCT fnp-3684 190 1 nature nature NOUN fnp-3684 190 2 580 580 NUM fnp-3684 190 3 : : PUNCT fnp-3684 190 4 396–401 396–401 NUM fnp-3684 190 5 , , PUNCT fnp-3684 190 6 2020 2020 NUM fnp-3684 190 7 . . PUNCT fnp-3684 191 1 https://doi.org/10.1038/s41586-020-2164-5 https://doi.org/10.1038/s41586-020-2164-5 NUM fnp-3684 191 2 yehia yehia PROPN fnp-3684 191 3 l l PROPN fnp-3684 191 4 , , PUNCT fnp-3684 191 5 eng eng PROPN fnp-3684 191 6 c. c. PROPN fnp-3684 191 7 pten pten PROPN fnp-3684 191 8 hamartoma hamartoma PROPN fnp-3684 191 9 tumor tumor NOUN fnp-3684 191 10 syndrome syndrome NOUN fnp-3684 191 11 . . PUNCT fnp-3684 192 1 2001 2001 NUM fnp-3684 192 2 nov nov NOUN fnp-3684 192 3 29 29 NUM fnp-3684 192 4 [ [ X fnp-3684 192 5 updated update VERB fnp-3684 192 6 2021 2021 NUM fnp-3684 192 7 feb feb NOUN fnp-3684 192 8 11 11 NUM fnp-3684 192 9 ] ] PUNCT fnp-3684 192 10 . . PUNCT fnp-3684 193 1 in in ADP fnp-3684 193 2 : : PUNCT fnp-3684 193 3 adam adam PROPN fnp-3684 193 4 mp mp PROPN fnp-3684 193 5 , , PUNCT fnp-3684 193 6 ardinger ardinger NOUN fnp-3684 193 7 hh hh PROPN fnp-3684 193 8 , , PUNCT fnp-3684 193 9 pagon pagon PROPN fnp-3684 193 10 ra ra PROPN fnp-3684 193 11 , , PUNCT fnp-3684 193 12 et et PROPN fnp-3684 193 13 al al PROPN fnp-3684 193 14 . . PROPN fnp-3684 193 15 , , PUNCT fnp-3684 193 16 editors editor NOUN fnp-3684 193 17 . . PUNCT fnp-3684 194 1 genereviews genereview NOUN fnp-3684 194 2 ® ® NOUN fnp-3684 194 3 [ [ X fnp-3684 194 4 internet internet NOUN fnp-3684 194 5 ] ] PUNCT fnp-3684 194 6 . . PUNCT fnp-3684 195 1 seattle seattle PROPN fnp-3684 195 2 ( ( PUNCT fnp-3684 195 3 wa wa PROPN fnp-3684 195 4 ): ): PUNCT fnp-3684 195 5 university university PROPN fnp-3684 195 6 of of ADP fnp-3684 195 7 washington washington PROPN fnp-3684 195 8 , , PUNCT fnp-3684 195 9 seattle seattle PROPN fnp-3684 195 10 ; ; PUNCT fnp-3684 195 11 1993 1993 NUM fnp-3684 195 12 - - SYM fnp-3684 195 13 2021 2021 NUM fnp-3684 195 14 . . PUNCT fnp-3684 196 1 copyright copyright NOUN fnp-3684 196 2 : : PUNCT fnp-3684 196 3 © © PROPN fnp-3684 196 4 2022 2022 NUM fnp-3684 196 5 the the DET fnp-3684 196 6 author(s author(s NOUN fnp-3684 196 7 ) ) PUNCT fnp-3684 196 8 . . PUNCT fnp-3684 197 1 this this PRON fnp-3684 197 2 is be AUX fnp-3684 197 3 an an DET fnp-3684 197 4 open open ADJ fnp-3684 197 5 access access NOUN fnp-3684 197 6 article article NOUN fnp-3684 197 7 distributed distribute VERB fnp-3684 197 8 under under ADP fnp-3684 197 9 the the DET fnp-3684 197 10 terms term NOUN fnp-3684 197 11 of of ADP fnp-3684 197 12 the the DET fnp-3684 197 13 creative creative ADJ fnp-3684 197 14 commons common NOUN fnp-3684 197 15 attribution attribution NOUN fnp-3684 197 16 4.0 4.0 NUM fnp-3684 197 17 international international ADJ fnp-3684 197 18 license license NOUN fnp-3684 197 19 ( ( PUNCT fnp-3684 197 20 https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/ PROPN fnp-3684 197 21 ) ) PUNCT fnp-3684 197 22 , , PUNCT fnp-3684 197 23 which which PRON fnp-3684 197 24 permits permit VERB fnp-3684 197 25 unrestricted unrestricted ADJ fnp-3684 197 26 use use NOUN fnp-3684 197 27 , , PUNCT fnp-3684 197 28 distribution distribution NOUN fnp-3684 197 29 , , PUNCT fnp-3684 197 30 and and CCONJ fnp-3684 197 31 reproduction reproduction NOUN fnp-3684 197 32 in in ADP fnp-3684 197 33 any any DET fnp-3684 197 34 medium medium NOUN fnp-3684 197 35 , , PUNCT fnp-3684 197 36 provided provide VERB fnp-3684 197 37 the the DET fnp-3684 197 38 original original ADJ fnp-3684 197 39 author author NOUN fnp-3684 197 40 and and CCONJ fnp-3684 197 41 source source NOUN fnp-3684 197 42 are be AUX fnp-3684 197 43 credited credit VERB fnp-3684 197 44 , , PUNCT fnp-3684 197 45 a a DET fnp-3684 197 46 link link NOUN fnp-3684 197 47 to to ADP fnp-3684 197 48 the the DET fnp-3684 197 49 creative creative ADJ fnp-3684 197 50 commons common NOUN fnp-3684 197 51 license license NOUN fnp-3684 197 52 is be AUX fnp-3684 197 53 provided provide VERB fnp-3684 197 54 , , PUNCT fnp-3684 197 55 and and CCONJ fnp-3684 197 56 any any DET fnp-3684 197 57 changes change NOUN fnp-3684 197 58 are be AUX fnp-3684 197 59 indicated indicate VERB fnp-3684 197 60 . . PUNCT fnp-3684 198 1 the the DET fnp-3684 198 2 creative creative ADJ fnp-3684 198 3 commons common NOUN fnp-3684 198 4 public public ADJ fnp-3684 198 5 domain domain NOUN fnp-3684 198 6 dedication dedication NOUN fnp-3684 198 7 waiver waiver NOUN fnp-3684 198 8 ( ( PUNCT fnp-3684 198 9 https://creativecommons.org/publicdomain/zero/1.0/ https://creativecommons.org/publicdomain/zero/1.0/ PROPN fnp-3684 198 10 ) ) PUNCT fnp-3684 198 11 applies apply VERB fnp-3684 198 12 to to ADP fnp-3684 198 13 the the DET fnp-3684 198 14 data datum NOUN fnp-3684 198 15 made make VERB fnp-3684 198 16 available available ADJ fnp-3684 198 17 in in ADP fnp-3684 198 18 this this DET fnp-3684 198 19 article article NOUN fnp-3684 198 20 , , PUNCT fnp-3684 198 21 unless unless SCONJ fnp-3684 198 22 otherwise otherwise ADV fnp-3684 198 23 stated state VERB fnp-3684 198 24 . . PUNCT