id	sid	tid	token	lemma	pos
fnp-3801	1	1	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	1	2	disorders	disorder	NOUN
fnp-3801	1	3	:	:	PUNCT
fnp-3801	1	4	2022	2022	NUM
fnp-3801	1	5	update	update	NOUN
fnp-3801	1	6	feel	feel	VERB
fnp-3801	1	7	free	free	ADJ
fnp-3801	1	8	to	to	PART
fnp-3801	1	9	add	add	VERB
fnp-3801	1	10	comments	comment	NOUN
fnp-3801	1	11	by	by	ADP
fnp-3801	1	12	clicking	click	VERB
fnp-3801	1	13	these	these	DET
fnp-3801	1	14	icons	icon	NOUN
fnp-3801	1	15	on	on	ADP
fnp-3801	1	16	the	the	DET
fnp-3801	1	17	sidebar	sidebar	NOUN
fnp-3801	1	18	free	free	ADJ
fnp-3801	1	19	neuropathology	neuropathology	NOUN
fnp-3801	1	20	3:8	3:8	NUM
fnp-3801	1	21	(	(	PUNCT
fnp-3801	1	22	2022	2022	NUM
fnp-3801	1	23	)	)	PUNCT
fnp-3801	1	24	review	review	VERB
fnp-3801	1	25	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	1	26	disorders	disorder	NOUN
fnp-3801	1	27	:	:	PUNCT
fnp-3801	1	28	2022	2022	NUM
fnp-3801	1	29	update	update	NOUN
fnp-3801	1	30	miguel	miguel	PROPN
fnp-3801	1	31	sabariego	sabariego	PROPN
fnp-3801	1	32	-	-	PUNCT
fnp-3801	1	33	navarro1	navarro1	PROPN
fnp-3801	1	34	,	,	PUNCT
fnp-3801	1	35	álvaro	álvaro	PROPN
fnp-3801	1	36	fernández	fernández	PROPN
fnp-3801	1	37	-	-	PUNCT
fnp-3801	1	38	blanco1	blanco1	NOUN
fnp-3801	1	39	,	,	PUNCT
fnp-3801	1	40	cesar	cesar	PROPN
fnp-3801	1	41	sierra1	sierra1	PROPN
fnp-3801	1	42	,	,	PUNCT
fnp-3801	1	43	mara	mara	PROPN
fnp-3801	1	44	dierssen1,2,3,4	dierssen1,2,3,4	ADJ
fnp-3801	1	45	1	1	NUM
fnp-3801	1	46	center	center	NOUN
fnp-3801	1	47	for	for	ADP
fnp-3801	1	48	genomic	genomic	ADJ
fnp-3801	1	49	regulation	regulation	NOUN
fnp-3801	1	50	,	,	PUNCT
fnp-3801	1	51	the	the	DET
fnp-3801	1	52	barcelona	barcelona	PROPN
fnp-3801	1	53	institute	institute	PROPN
fnp-3801	1	54	for	for	ADP
fnp-3801	1	55	science	science	NOUN
fnp-3801	1	56	and	and	CCONJ
fnp-3801	1	57	technology	technology	NOUN
fnp-3801	1	58	,	,	PUNCT
fnp-3801	1	59	barcelona	barcelona	PROPN
fnp-3801	1	60	,	,	PUNCT
fnp-3801	1	61	spain	spain	PROPN
fnp-3801	1	62	2	2	NUM
fnp-3801	1	63	neurosciences	neuroscience	NOUN
fnp-3801	1	64	research	research	NOUN
fnp-3801	1	65	program	program	NOUN
fnp-3801	1	66	,	,	PUNCT
fnp-3801	1	67	hospital	hospital	NOUN
fnp-3801	1	68	del	del	PROPN
fnp-3801	1	69	mar	mar	PROPN
fnp-3801	1	70	medical	medical	PROPN
fnp-3801	1	71	research	research	PROPN
fnp-3801	1	72	institute	institute	PROPN
fnp-3801	1	73	,	,	PUNCT
fnp-3801	1	74	barcelona	barcelona	PROPN
fnp-3801	1	75	,	,	PUNCT
fnp-3801	1	76	spain	spain	PROPN
fnp-3801	1	77	3	3	NUM
fnp-3801	1	78	university	university	NOUN
fnp-3801	1	79	pompeu	pompeu	NOUN
fnp-3801	1	80	fabra	fabra	PROPN
fnp-3801	1	81	,	,	PUNCT
fnp-3801	1	82	barcelona	barcelona	PROPN
fnp-3801	1	83	,	,	PUNCT
fnp-3801	1	84	spain	spain	PROPN
fnp-3801	1	85	4	4	NUM
fnp-3801	1	86	biomedical	biomedical	ADJ
fnp-3801	1	87	research	research	NOUN
fnp-3801	1	88	networking	network	VERB
fnp-3801	1	89	center	center	NOUN
fnp-3801	1	90	for	for	ADP
fnp-3801	1	91	rare	rare	ADJ
fnp-3801	1	92	diseases	disease	NOUN
fnp-3801	1	93	(	(	PUNCT
fnp-3801	1	94	ciberer	ciberer	NOUN
fnp-3801	1	95	)	)	PUNCT
fnp-3801	1	96	,	,	PUNCT
fnp-3801	1	97	barcelona	barcelona	PROPN
fnp-3801	1	98	,	,	PUNCT
fnp-3801	1	99	spain	spain	PROPN
fnp-3801	1	100	corresponding	corresponding	PROPN
fnp-3801	1	101	author	author	NOUN
fnp-3801	1	102	:	:	PUNCT
fnp-3801	1	103	mara	mara	PROPN
fnp-3801	1	104	dierssen	dierssen	PROPN
fnp-3801	1	105	·	·	PUNCT
fnp-3801	1	106	systems	system	NOUN
fnp-3801	1	107	biology	biology	NOUN
fnp-3801	1	108	program	program	NOUN
fnp-3801	1	109	·	·	PUNCT
fnp-3801	1	110	crg	crg	NOUN
fnp-3801	1	111	-	-	PUNCT
fnp-3801	1	112	center	center	NOUN
fnp-3801	1	113	for	for	ADP
fnp-3801	1	114	genomic	genomic	ADJ
fnp-3801	1	115	regulation	regulation	NOUN
fnp-3801	1	116	·	·	PUNCT
fnp-3801	1	117	c/	c/	NOUN
fnp-3801	1	118	dr	dr	PROPN
fnp-3801	1	119	.	.	PROPN
fnp-3801	1	120	aiguader	aiguader	PROPN
fnp-3801	1	121	,	,	PUNCT
fnp-3801	1	122	88	88	NUM
fnp-3801	1	123	·	·	PUNCT
fnp-3801	1	124	prbb	prbb	NOUN
fnp-3801	1	125	building	build	VERB
fnp-3801	1	126	·	·	PUNCT
fnp-3801	1	127	08003	08003	NUM
fnp-3801	2	1	barcelona	barcelona	PROPN
fnp-3801	2	2	·	·	PUNCT
fnp-3801	2	3	spain	spain	PROPN
fnp-3801	2	4	mara.dierssen@crg.eu	mara.dierssen@crg.eu	PROPN
fnp-3801	2	5	submitted	submit	VERB
fnp-3801	2	6	:	:	PUNCT
fnp-3801	2	7	09	09	NUM
fnp-3801	2	8	february	february	NOUN
fnp-3801	2	9	2022	2022	NUM
fnp-3801	2	10	accepted	accept	VERB
fnp-3801	2	11	:	:	PUNCT
fnp-3801	2	12	08	08	NUM
fnp-3801	2	13	march	march	PROPN
fnp-3801	2	14	2022	2022	NUM
fnp-3801	2	15	copyedited	copyedit	VERB
fnp-3801	2	16	by	by	ADP
fnp-3801	2	17	:	:	PUNCT
fnp-3801	2	18	christian	christian	PROPN
fnp-3801	2	19	thomas	thomas	PROPN
fnp-3801	2	20	published	publish	VERB
fnp-3801	2	21	:	:	PUNCT
fnp-3801	2	22	21	21	NUM
fnp-3801	2	23	march	march	NOUN
fnp-3801	2	24	2022	2022	NUM
fnp-3801	2	25	https://doi.org/10.17879/freeneuropathology-2022-3801	https://doi.org/10.17879/freeneuropathology-2022-3801	CCONJ
fnp-3801	2	26	keywords	keyword	NOUN
fnp-3801	2	27	:	:	PUNCT
fnp-3801	2	28	mitovesicles	mitovesicle	NOUN
fnp-3801	2	29	,	,	PUNCT
fnp-3801	2	30	repeatome	repeatome	NOUN
fnp-3801	2	31	,	,	PUNCT
fnp-3801	2	32	trnas	trnas	NOUN
fnp-3801	2	33	methylation	methylation	NOUN
fnp-3801	2	34	,	,	PUNCT
fnp-3801	2	35	chromatin	chromatin	NOUN
fnp-3801	2	36	remodeler	remodeler	NOUN
fnp-3801	2	37	,	,	PUNCT
fnp-3801	2	38	autism	autism	NOUN
fnp-3801	2	39	spectrum	spectrum	NOUN
fnp-3801	2	40	disorder	disorder	NOUN
fnp-3801	2	41	,	,	PUNCT
fnp-3801	2	42	aicardi	aicardi	NOUN
fnp-3801	2	43	-	-	PUNCT
fnp-3801	2	44	goutières	goutière	NOUN
fnp-3801	2	45	syndrome	syndrome	NOUN
fnp-3801	2	46	abstract	abstract	NOUN
fnp-3801	2	47	with	with	ADP
fnp-3801	2	48	a	a	DET
fnp-3801	2	49	prevalence	prevalence	NOUN
fnp-3801	2	50	of	of	ADP
fnp-3801	2	51	2	2	NUM
fnp-3801	2	52	-	-	SYM
fnp-3801	2	53	4	4	NUM
fnp-3801	2	54	%	%	NOUN
fnp-3801	2	55	of	of	ADP
fnp-3801	2	56	the	the	DET
fnp-3801	2	57	worldwide	worldwide	ADJ
fnp-3801	2	58	population	population	NOUN
fnp-3801	2	59	,	,	PUNCT
fnp-3801	2	60	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	2	61	disorders	disorder	NOUN
fnp-3801	2	62	(	(	PUNCT
fnp-3801	2	63	ndds	ndds	X
fnp-3801	2	64	)	)	PUNCT
fnp-3801	2	65	comprise	comprise	VERB
fnp-3801	2	66	a	a	DET
fnp-3801	2	67	heterogeneous	heterogeneous	ADJ
fnp-3801	2	68	group	group	NOUN
fnp-3801	2	69	of	of	ADP
fnp-3801	2	70	disorders	disorder	NOUN
fnp-3801	2	71	associated	associate	VERB
fnp-3801	2	72	with	with	ADP
fnp-3801	2	73	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	2	74	dysfunction	dysfunction	NOUN
fnp-3801	2	75	,	,	PUNCT
fnp-3801	2	76	including	include	VERB
fnp-3801	2	77	intellectual	intellectual	ADJ
fnp-3801	2	78	disability	disability	NOUN
fnp-3801	2	79	(	(	PUNCT
fnp-3801	2	80	i	i	PROPN
fnp-3801	2	81	d	d	PROPN
fnp-3801	2	82	)	)	PUNCT
fnp-3801	2	83	,	,	PUNCT
fnp-3801	2	84	autism	autism	NOUN
fnp-3801	2	85	spectrum	spectrum	NOUN
fnp-3801	2	86	disorder	disorder	NOUN
fnp-3801	2	87	(	(	PUNCT
fnp-3801	2	88	asd	asd	PROPN
fnp-3801	2	89	)	)	PUNCT
fnp-3801	2	90	,	,	PUNCT
fnp-3801	2	91	down	down	ADP
fnp-3801	2	92	syndrome	syndrome	NOUN
fnp-3801	2	93	(	(	PUNCT
fnp-3801	2	94	ds	ds	ADJ
fnp-3801	2	95	)	)	PUNCT
fnp-3801	2	96	and	and	CCONJ
fnp-3801	2	97	attention	attention	NOUN
fnp-3801	2	98	-	-	PUNCT
fnp-3801	2	99	deficit	deficit	NOUN
fnp-3801	2	100	/	/	SYM
fnp-3801	2	101	hyperactivity	hyperactivity	NOUN
fnp-3801	2	102	disorder	disorder	NOUN
fnp-3801	2	103	(	(	PUNCT
fnp-3801	2	104	adhd	adhd	NOUN
fnp-3801	2	105	)	)	PUNCT
fnp-3801	2	106	among	among	ADP
fnp-3801	2	107	others	other	NOUN
fnp-3801	2	108	.	.	PUNCT
fnp-3801	3	1	however	however	ADV
fnp-3801	3	2	,	,	PUNCT
fnp-3801	3	3	due	due	ADP
fnp-3801	3	4	to	to	ADP
fnp-3801	3	5	their	their	PRON
fnp-3801	3	6	heterogeneity	heterogeneity	NOUN
fnp-3801	3	7	and	and	CCONJ
fnp-3801	3	8	overlapping	overlap	VERB
fnp-3801	3	9	clinical	clinical	ADJ
fnp-3801	3	10	features	feature	NOUN
fnp-3801	3	11	,	,	PUNCT
fnp-3801	3	12	ndds	ndd	NOUN
fnp-3801	3	13	such	such	ADJ
fnp-3801	3	14	as	as	SCONJ
fnp-3801	3	15	asd	asd	PROPN
fnp-3801	3	16	are	be	AUX
fnp-3801	3	17	often	often	ADV
fnp-3801	3	18	misdiagnosed	misdiagnose	VERB
fnp-3801	3	19	,	,	PUNCT
fnp-3801	3	20	while	while	SCONJ
fnp-3801	3	21	for	for	SCONJ
fnp-3801	3	22	others	other	NOUN
fnp-3801	3	23	with	with	ADP
fnp-3801	3	24	more	more	ADJ
fnp-3801	3	25	distinct	distinct	ADJ
fnp-3801	3	26	symptoms	symptom	NOUN
fnp-3801	3	27	,	,	PUNCT
fnp-3801	3	28	such	such	ADJ
fnp-3801	3	29	as	as	ADP
fnp-3801	3	30	rett	rett	PROPN
fnp-3801	3	31	syndrome	syndrome	PROPN
fnp-3801	3	32	or	or	CCONJ
fnp-3801	3	33	ds	ds	PROPN
fnp-3801	3	34	,	,	PUNCT
fnp-3801	3	35	the	the	DET
fnp-3801	3	36	mechanisms	mechanism	NOUN
fnp-3801	3	37	underlying	underlie	VERB
fnp-3801	3	38	their	their	PRON
fnp-3801	3	39	pathogenesis	pathogenesis	NOUN
fnp-3801	3	40	remain	remain	VERB
fnp-3801	3	41	elusive	elusive	ADJ
fnp-3801	3	42	.	.	PUNCT
fnp-3801	4	1	last	last	ADJ
fnp-3801	4	2	year	year	NOUN
fnp-3801	4	3	,	,	PUNCT
fnp-3801	4	4	important	important	ADJ
fnp-3801	4	5	steps	step	NOUN
fnp-3801	4	6	in	in	ADP
fnp-3801	4	7	the	the	DET
fnp-3801	4	8	mechanistic	mechanistic	ADJ
fnp-3801	4	9	understanding	understanding	NOUN
fnp-3801	4	10	of	of	ADP
fnp-3801	4	11	several	several	ADJ
fnp-3801	4	12	ndds	ndd	NOUN
fnp-3801	4	13	have	have	AUX
fnp-3801	4	14	been	be	AUX
fnp-3801	4	15	achieved	achieve	VERB
fnp-3801	4	16	.	.	PUNCT
fnp-3801	5	1	new	new	ADJ
fnp-3801	5	2	preclinical	preclinical	ADJ
fnp-3801	5	3	models	model	NOUN
fnp-3801	5	4	demonstrated	demonstrate	VERB
fnp-3801	5	5	causality	causality	NOUN
fnp-3801	5	6	between	between	ADP
fnp-3801	5	7	pak3	pak3	NOUN
fnp-3801	5	8	mutations	mutation	NOUN
fnp-3801	5	9	and	and	CCONJ
fnp-3801	5	10	disorders	disorder	NOUN
fnp-3801	5	11	associated	associate	VERB
fnp-3801	5	12	with	with	ADP
fnp-3801	5	13	social	social	ADJ
fnp-3801	5	14	deficiencies	deficiency	NOUN
fnp-3801	5	15	.	.	PUNCT
fnp-3801	6	1	arid1b	arid1b	PROPN
fnp-3801	6	2	mutations	mutation	NOUN
fnp-3801	6	3	have	have	AUX
fnp-3801	6	4	been	be	AUX
fnp-3801	6	5	linked	link	VERB
fnp-3801	6	6	to	to	ADP
fnp-3801	6	7	neuroectoderm	neuroectoderm	NOUN
fnp-3801	6	8	specification	specification	NOUN
fnp-3801	6	9	in	in	ADP
fnp-3801	6	10	coffin	coffin	NOUN
fnp-3801	6	11	-	-	PUNCT
fnp-3801	6	12	siris	siris	NOUN
fnp-3801	6	13	syndrome	syndrome	NOUN
fnp-3801	6	14	and	and	CCONJ
fnp-3801	6	15	dna	dna	PROPN
fnp-3801	6	16	damage	damage	NOUN
fnp-3801	6	17	was	be	AUX
fnp-3801	6	18	established	establish	VERB
fnp-3801	6	19	as	as	ADP
fnp-3801	6	20	an	an	DET
fnp-3801	6	21	important	important	ADJ
fnp-3801	6	22	pathologic	pathologic	ADJ
fnp-3801	6	23	mechanism	mechanism	NOUN
fnp-3801	6	24	in	in	ADP
fnp-3801	6	25	aicardi	aicardi	NOUN
fnp-3801	6	26	-	-	PUNCT
fnp-3801	6	27	goutières	goutière	NOUN
fnp-3801	6	28	syndrome	syndrome	NOUN
fnp-3801	6	29	.	.	PUNCT
fnp-3801	7	1	moreover	moreover	ADV
fnp-3801	7	2	,	,	PUNCT
fnp-3801	7	3	alterations	alteration	NOUN
fnp-3801	7	4	in	in	ADP
fnp-3801	7	5	basic	basic	ADJ
fnp-3801	7	6	molecular	molecular	ADJ
fnp-3801	7	7	processes	process	NOUN
fnp-3801	7	8	including	include	VERB
fnp-3801	7	9	translation	translation	NOUN
fnp-3801	7	10	and	and	CCONJ
fnp-3801	7	11	histone	histone	NOUN
fnp-3801	7	12	acetylation	acetylation	NOUN
fnp-3801	7	13	have	have	AUX
fnp-3801	7	14	been	be	AUX
fnp-3801	7	15	established	establish	VERB
fnp-3801	7	16	as	as	ADP
fnp-3801	7	17	major	major	ADJ
fnp-3801	7	18	traits	trait	NOUN
fnp-3801	7	19	in	in	ADP
fnp-3801	7	20	the	the	DET
fnp-3801	7	21	pathology	pathology	NOUN
fnp-3801	7	22	of	of	ADP
fnp-3801	7	23	x	x	ADV
fnp-3801	7	24	-	-	VERB
fnp-3801	7	25	linked	link	VERB
fnp-3801	7	26	i	i	PROPN
fnp-3801	7	27	d	d	PROPN
fnp-3801	7	28	and	and	CCONJ
fnp-3801	7	29	rett	rett	PROPN
fnp-3801	7	30	syndrome	syndrome	PROPN
fnp-3801	7	31	,	,	PUNCT
fnp-3801	7	32	revealing	reveal	VERB
fnp-3801	7	33	new	new	ADJ
fnp-3801	7	34	pathogenetic	pathogenetic	ADJ
fnp-3801	7	35	mechanisms	mechanism	NOUN
fnp-3801	7	36	.	.	PUNCT
fnp-3801	8	1	last	last	ADJ
fnp-3801	8	2	year	year	NOUN
fnp-3801	8	3	,	,	PUNCT
fnp-3801	8	4	advances	advance	NOUN
fnp-3801	8	5	in	in	ADP
fnp-3801	8	6	bioinformatics	bioinformatics	NOUN
fnp-3801	8	7	have	have	AUX
fnp-3801	8	8	begun	begin	VERB
fnp-3801	8	9	to	to	PART
fnp-3801	8	10	shed	shed	VERB
fnp-3801	8	11	light	light	NOUN
fnp-3801	8	12	on	on	ADP
fnp-3801	8	13	the	the	DET
fnp-3801	8	14	human	human	ADJ
fnp-3801	8	15	repeatome	repeatome	NOUN
fnp-3801	8	16	,	,	PUNCT
fnp-3801	8	17	a	a	DET
fnp-3801	8	18	largely	largely	ADV
fnp-3801	8	19	unexplored	unexplored	ADJ
fnp-3801	8	20	part	part	NOUN
fnp-3801	8	21	of	of	ADP
fnp-3801	8	22	our	our	PRON
fnp-3801	8	23	genome	genome	NOUN
fnp-3801	8	24	,	,	PUNCT
fnp-3801	8	25	and	and	CCONJ
fnp-3801	8	26	how	how	SCONJ
fnp-3801	8	27	alterations	alteration	NOUN
fnp-3801	8	28	in	in	ADP
fnp-3801	8	29	these	these	DET
fnp-3801	8	30	sequences	sequence	NOUN
fnp-3801	8	31	have	have	VERB
fnp-3801	8	32	a	a	DET
fnp-3801	8	33	central	central	ADJ
fnp-3801	8	34	role	role	NOUN
fnp-3801	8	35	in	in	ADP
fnp-3801	8	36	asd	asd	PROPN
fnp-3801	8	37	.	.	PUNCT
fnp-3801	9	1	the	the	DET
fnp-3801	9	2	role	role	NOUN
fnp-3801	9	3	of	of	ADP
fnp-3801	9	4	mitochondria	mitochondria	NOUN
fnp-3801	9	5	in	in	ADP
fnp-3801	9	6	neuropathology	neuropathology	NOUN
fnp-3801	9	7	was	be	AUX
fnp-3801	9	8	clarified	clarify	VERB
fnp-3801	9	9	last	last	ADJ
fnp-3801	9	10	year	year	NOUN
fnp-3801	9	11	with	with	ADP
fnp-3801	9	12	the	the	DET
fnp-3801	9	13	discovery	discovery	NOUN
fnp-3801	9	14	of	of	ADP
fnp-3801	9	15	previously	previously	ADV
fnp-3801	9	16	unknown	unknown	ADJ
fnp-3801	9	17	vesicles	vesicle	NOUN
fnp-3801	9	18	derived	derive	VERB
fnp-3801	9	19	from	from	ADP
fnp-3801	9	20	mitochondria	mitochondria	NOUN
fnp-3801	9	21	with	with	ADP
fnp-3801	9	22	a	a	DET
fnp-3801	9	23	putative	putative	ADJ
fnp-3801	9	24	role	role	NOUN
fnp-3801	9	25	in	in	ADP
fnp-3801	9	26	ds	ds	PROPN
fnp-3801	9	27	.	.	PUNCT
fnp-3801	10	1	an	an	DET
fnp-3801	10	2	interesting	interesting	ADJ
fnp-3801	10	3	discovery	discovery	NOUN
fnp-3801	10	4	in	in	ADP
fnp-3801	10	5	the	the	DET
fnp-3801	10	6	field	field	NOUN
fnp-3801	10	7	of	of	ADP
fnp-3801	10	8	basic	basic	ADJ
fnp-3801	10	9	neurodevelopment	neurodevelopment	NOUN
fnp-3801	10	10	showed	show	VERB
fnp-3801	10	11	that	that	SCONJ
fnp-3801	10	12	during	during	ADP
fnp-3801	10	13	postnatal	postnatal	ADJ
fnp-3801	10	14	brain	brain	NOUN
fnp-3801	10	15	development	development	NOUN
fnp-3801	10	16	,	,	PUNCT
fnp-3801	10	17	changes	change	NOUN
fnp-3801	10	18	in	in	ADP
fnp-3801	10	19	genome	genome	NOUN
fnp-3801	10	20	architecture	architecture	NOUN
fnp-3801	10	21	and	and	CCONJ
fnp-3801	10	22	transcriptional	transcriptional	ADJ
fnp-3801	10	23	dynamics	dynamic	NOUN
fnp-3801	10	24	progress	progress	VERB
fnp-3801	10	25	independently	independently	ADV
fnp-3801	10	26	of	of	ADP
fnp-3801	10	27	sensory	sensory	ADJ
fnp-3801	10	28	experience	experience	NOUN
fnp-3801	10	29	.	.	PUNCT
fnp-3801	11	1	finally	finally	ADV
fnp-3801	11	2	,	,	PUNCT
fnp-3801	11	3	our	our	PRON
fnp-3801	11	4	neurocentric	neurocentric	ADJ
fnp-3801	11	5	views	view	NOUN
fnp-3801	11	6	of	of	ADP
fnp-3801	11	7	ndds	ndd	NOUN
fnp-3801	11	8	are	be	AUX
fnp-3801	11	9	changing	change	VERB
fnp-3801	11	10	as	as	SCONJ
fnp-3801	11	11	new	new	ADJ
fnp-3801	11	12	players	player	NOUN
fnp-3801	11	13	such	such	ADJ
fnp-3801	11	14	as	as	ADP
fnp-3801	11	15	astrocytes	astrocyte	NOUN
fnp-3801	11	16	are	be	AUX
fnp-3801	11	17	revealed	reveal	VERB
fnp-3801	11	18	to	to	PART
fnp-3801	11	19	be	be	AUX
fnp-3801	11	20	crucial	crucial	ADJ
fnp-3801	11	21	in	in	ADP
fnp-3801	11	22	neuropathology	neuropathology	NOUN
fnp-3801	11	23	.	.	PUNCT
fnp-3801	12	1	the	the	DET
fnp-3801	12	2	role	role	NOUN
fnp-3801	12	3	of	of	ADP
fnp-3801	12	4	astrocytes	astrocyte	NOUN
fnp-3801	12	5	has	have	AUX
fnp-3801	12	6	been	be	AUX
fnp-3801	12	7	clarified	clarify	VERB
fnp-3801	12	8	for	for	ADP
fnp-3801	12	9	some	some	DET
fnp-3801	12	10	pathologies	pathology	NOUN
fnp-3801	12	11	such	such	ADJ
fnp-3801	12	12	as	as	ADP
fnp-3801	12	13	asd	asd	NOUN
fnp-3801	12	14	and	and	CCONJ
fnp-3801	12	15	ds	ds	ADJ
fnp-3801	12	16	,	,	PUNCT
fnp-3801	12	17	linking	link	VERB
fnp-3801	12	18	well	well	ADV
fnp-3801	12	19	-	-	PUNCT
fnp-3801	12	20	known	know	VERB
fnp-3801	12	21	genetic	genetic	ADJ
fnp-3801	12	22	mutations	mutation	NOUN
fnp-3801	12	23	to	to	ADP
fnp-3801	12	24	impaired	impaired	ADJ
fnp-3801	12	25	astrocyte	astrocyte	NOUN
fnp-3801	12	26	function	function	NOUN
fnp-3801	12	27	.	.	PUNCT
fnp-3801	13	1	abbreviations	abbreviation	NOUN
fnp-3801	13	2	adar1	adar1	NOUN
fnp-3801	13	3	double	double	ADV
fnp-3801	13	4	-	-	PUNCT
fnp-3801	13	5	stranded	strand	VERB
fnp-3801	13	6	rna	rna	NOUN
fnp-3801	13	7	-	-	PUNCT
fnp-3801	13	8	specific	specific	ADJ
fnp-3801	13	9	adenosine	adenosine	NOUN
fnp-3801	13	10	deaminase	deaminase	NOUN
fnp-3801	13	11	,	,	PUNCT
fnp-3801	13	12	ags	ag	NOUN
fnp-3801	13	13	aicardi	aicardi	NOUN
fnp-3801	13	14	-	-	PUNCT
fnp-3801	13	15	goutières	goutière	NOUN
fnp-3801	13	16	syndrome	syndrome	NOUN
fnp-3801	13	17	,	,	PUNCT
fnp-3801	13	18	asd	asd	PROPN
fnp-3801	13	19	autism	autism	NOUN
fnp-3801	13	20	spectrum	spectrum	NOUN
fnp-3801	13	21	disorder	disorder	NOUN
fnp-3801	13	22	,	,	PUNCT
fnp-3801	13	23	atp	atp	NOUN
fnp-3801	13	24	adenosine	adenosine	NOUN
fnp-3801	13	25	triphosphate	triphosphate	NOUN
fnp-3801	13	26	,	,	PUNCT
fnp-3801	13	27	cgas	cgas	ADJ
fnp-3801	13	28	gmp	gmp	PROPN
fnp-3801	13	29	-	-	PUNCT
fnp-3801	13	30	amp	amp	NOUN
fnp-3801	13	31	synthase	synthase	NOUN
fnp-3801	13	32	,	,	PUNCT
fnp-3801	13	33	cko	cko	PROPN
fnp-3801	13	34	conditional	conditional	ADJ
fnp-3801	13	35	knockout	knockout	PROPN
fnp-3801	13	36	,	,	PUNCT
fnp-3801	13	37	dip	dip	NOUN
fnp-3801	13	38	-	-	PUNCT
fnp-3801	13	39	c	c	NOUN
fnp-3801	13	40	diploid	diploid	ADJ
fnp-3801	13	41	chromatin	chromatin	NOUN
fnp-3801	13	42	conformation	conformation	NOUN
fnp-3801	13	43	capture	capture	NOUN
fnp-3801	13	44	,	,	PUNCT
fnp-3801	13	45	dna	dna	PROPN
fnp-3801	13	46	deoxyribonucleic	deoxyribonucleic	VERB
fnp-3801	13	47	acid	acid	NOUN
fnp-3801	13	48	,	,	PUNCT
fnp-3801	13	49	ds	ds	VERB
fnp-3801	13	50	down	down	ADP
fnp-3801	13	51	syndrome	syndrome	NOUN
fnp-3801	13	52	,	,	PUNCT
fnp-3801	13	53	ev	ev	INTJ
fnp-3801	13	54	extracellular	extracellular	ADJ
fnp-3801	13	55	vesicles	vesicle	NOUN
fnp-3801	13	56	,	,	PUNCT
fnp-3801	13	57	gaba	gaba	PROPN
fnp-3801	13	58	gamma	gamma	NOUN
fnp-3801	13	59	-	-	PUNCT
fnp-3801	13	60	aminobutyric	aminobutyric	ADJ
fnp-3801	13	61	acid	acid	NOUN
fnp-3801	13	62	,	,	PUNCT
fnp-3801	13	63	γh2ax	γh2ax	NUM
fnp-3801	13	64	:	:	PUNCT
fnp-3801	13	65	h2a	h2a	ADP
fnp-3801	13	66	histone	histone	NOUN
fnp-3801	13	67	family	family	NOUN
fnp-3801	13	68	member	member	NOUN
fnp-3801	13	69	x	x	PROPN
fnp-3801	13	70	,	,	PUNCT
fnp-3801	13	71	hipsc	hipsc	ADJ
fnp-3801	13	72	human	human	ADJ
fnp-3801	13	73	induced	induce	VERB
fnp-3801	13	74	pluripotent	pluripotent	ADJ
fnp-3801	13	75	stem	stem	NOUN
fnp-3801	13	76	cells	cell	NOUN
fnp-3801	13	77	,	,	PUNCT
fnp-3801	13	78	iba1	iba1	X
fnp-3801	13	79	ionized	ionize	VERB
fnp-3801	13	80	calcium	calcium	NOUN
fnp-3801	13	81	-	-	PUNCT
fnp-3801	13	82	binding	bind	VERB
fnp-3801	13	83	adaptor	adaptor	NOUN
fnp-3801	13	84	molecule	molecule	NOUN
fnp-3801	13	85	1	1	NUM
fnp-3801	13	86	,	,	PUNCT
fnp-3801	13	87	i	i	PROPN
fnp-3801	13	88	d	d	PROPN
fnp-3801	13	89	intellectual	intellectual	PROPN
fnp-3801	13	90	disability	disability	PROPN
fnp-3801	13	91	,	,	PUNCT
fnp-3801	13	92	ifn	ifn	PROPN
fnp-3801	13	93	interferon	interferon	ADJ
fnp-3801	13	94	,	,	PUNCT
fnp-3801	13	95	ip3r2	ip3r2	PROPN
fnp-3801	13	96	2	2	NUM
fnp-3801	13	97	inositol	inositol	NOUN
fnp-3801	13	98	1,4,5	1,4,5	NUM
fnp-3801	13	99	-	-	PUNCT
fnp-3801	13	100	trisphosphate	trisphosphate	NOUN
fnp-3801	13	101	receptors	receptor	NOUN
fnp-3801	13	102	,	,	PUNCT
fnp-3801	13	103	lc	lc	NOUN
fnp-3801	13	104	-	-	PUNCT
fnp-3801	13	105	ms	ms	NOUN
fnp-3801	13	106	liquid	liquid	ADJ
fnp-3801	13	107	chromatography	chromatography	NOUN
fnp-3801	13	108	-	-	PUNCT
fnp-3801	13	109	mass	mass	NOUN
fnp-3801	13	110	spectrometry	spectrometry	NOUN
fnp-3801	13	111	,	,	PUNCT
fnp-3801	13	112	mecp2	mecp2	NOUN
fnp-3801	13	113	methyl	methyl	NOUN
fnp-3801	13	114	cpg	cpg	NOUN
fnp-3801	13	115	binding	bind	VERB
fnp-3801	13	116	protein	protein	NOUN
fnp-3801	13	117	2	2	NUM
fnp-3801	13	118	,	,	PUNCT
fnp-3801	13	119	ndd	ndd	PROPN
fnp-3801	13	120	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	13	121	disorder	disorder	NOUN
fnp-3801	13	122	,	,	PUNCT
fnp-3801	13	123	rna	rna	NOUN
fnp-3801	13	124	ribonucleic	ribonucleic	NOUN
fnp-3801	13	125	acid	acid	NOUN
fnp-3801	13	126	,	,	PUNCT
fnp-3801	13	127	rnaseh2	rnaseh2	NOUN
fnp-3801	13	128	ribonuclease	ribonuclease	NOUN
fnp-3801	13	129	h2	h2	PROPN
fnp-3801	13	130	,	,	PUNCT
fnp-3801	13	131	nmda	nmda	ADJ
fnp-3801	13	132	n	n	CCONJ
fnp-3801	13	133	-	-	PUNCT
fnp-3801	13	134	methyl	methyl	NOUN
fnp-3801	13	135	-	-	PUNCT
fnp-3801	13	136	d	d	NOUN
fnp-3801	13	137	-	-	NOUN
fnp-3801	13	138	aspartic	aspartic	ADJ
fnp-3801	13	139	acid	acid	NOUN
fnp-3801	13	140	or	or	CCONJ
fnp-3801	13	141	n	n	CCONJ
fnp-3801	13	142	-	-	PUNCT
fnp-3801	13	143	methyl	methyl	NOUN
fnp-3801	13	144	-	-	PUNCT
fnp-3801	13	145	d	d	NOUN
fnp-3801	13	146	-	-	NOUN
fnp-3801	13	147	aspartate	aspartate	NOUN
fnp-3801	13	148	,	,	PUNCT
fnp-3801	13	149	nova1	nova1	NOUN
fnp-3801	13	150	neuro	neuro	NOUN
fnp-3801	13	151	-	-	PUNCT
fnp-3801	13	152	oncological	oncological	ADJ
fnp-3801	13	153	ventral	ventral	NOUN
fnp-3801	13	154	antigen	antigen	ADJ
fnp-3801	13	155	1	1	NUM
fnp-3801	13	156	,	,	PUNCT
fnp-3801	13	157	  	  	SPACE
fnp-3801	13	158	psd95	psd95	VERB
fnp-3801	13	159	postsynaptic	postsynaptic	ADJ
fnp-3801	13	160	density	density	NOUN
fnp-3801	13	161	95	95	NUM
fnp-3801	13	162	,	,	PUNCT
fnp-3801	13	163	rtt	rtt	PROPN
fnp-3801	13	164	rett	rett	PROPN
fnp-3801	13	165	syndrome	syndrome	PROPN
fnp-3801	13	166	,	,	PUNCT
fnp-3801	13	167	rps4y1	rps4y1	NOUN
fnp-3801	13	168	40s	40	NOUN
fnp-3801	13	169	ribosomal	ribosomal	NOUN
fnp-3801	13	170	protein	protein	NOUN
fnp-3801	13	171	s4	s4	NOUN
fnp-3801	13	172	,	,	PUNCT
fnp-3801	13	173	tads	tad	NOUN
fnp-3801	13	174	topologically	topologically	ADV
fnp-3801	13	175	associated	associate	VERB
fnp-3801	13	176	domains	domain	NOUN
fnp-3801	13	177	,	,	PUNCT
fnp-3801	13	178	trs	trs	PROPN
fnp-3801	13	179	tandem	tandem	PROPN
fnp-3801	13	180	-	-	PUNCT
fnp-3801	13	181	repeat	repeat	NOUN
fnp-3801	13	182	sequence	sequence	NOUN
fnp-3801	13	183	,	,	PUNCT
fnp-3801	13	184	trex1	trex1	NOUN
fnp-3801	14	1	three	three	NUM
fnp-3801	14	2	prime	prime	ADJ
fnp-3801	14	3	repair	repair	NOUN
fnp-3801	14	4	exonuclease	exonuclease	NOUN
fnp-3801	14	5	1	1	NUM
fnp-3801	14	6	,	,	PUNCT
fnp-3801	14	7	trna	trna	NOUN
fnp-3801	14	8	transfer	transfer	NOUN
fnp-3801	14	9	rnas	rna	NOUN
fnp-3801	14	10	,	,	PUNCT
fnp-3801	14	11	xlid	xlid	PROPN
fnp-3801	14	12	x	x	VERB
fnp-3801	14	13	-	-	VERB
fnp-3801	14	14	linked	link	VERB
fnp-3801	14	15	intellectual	intellectual	ADJ
fnp-3801	14	16	disability	disability	NOUN
fnp-3801	14	17	.	.	PUNCT
fnp-3801	15	1	introduction	introduction	NOUN
fnp-3801	15	2	single	single	ADJ
fnp-3801	15	3	-	-	PUNCT
fnp-3801	15	4	term	term	NOUN
fnp-3801	15	5	search	search	NOUN
fnp-3801	15	6	in	in	ADP
fnp-3801	15	7	the	the	DET
fnp-3801	15	8	pubmed	pubmed	PROPN
fnp-3801	15	9	database	database	NOUN
fnp-3801	15	10	with	with	ADP
fnp-3801	15	11	the	the	DET
fnp-3801	15	12	search	search	NOUN
fnp-3801	15	13	term	term	NOUN
fnp-3801	15	14	“	"	PUNCT
fnp-3801	15	15	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	15	16	disorders	disorder	NOUN
fnp-3801	15	17	”	"	PUNCT
fnp-3801	15	18	from	from	ADP
fnp-3801	15	19	january	january	PROPN
fnp-3801	15	20	1st	1st	NOUN
fnp-3801	15	21	to	to	ADP
fnp-3801	15	22	december	december	PROPN
fnp-3801	15	23	31st	31st	NOUN
fnp-3801	15	24	2021	2021	NUM
fnp-3801	15	25	retrieved	retrieve	VERB
fnp-3801	15	26	more	more	ADJ
fnp-3801	15	27	than	than	ADP
fnp-3801	15	28	10,000	10,000	NUM
fnp-3801	15	29	papers	paper	NOUN
fnp-3801	15	30	.	.	PUNCT
fnp-3801	16	1	in	in	ADP
fnp-3801	16	2	this	this	DET
fnp-3801	16	3	review	review	NOUN
fnp-3801	16	4	,	,	PUNCT
fnp-3801	16	5	we	we	PRON
fnp-3801	16	6	selected	select	VERB
fnp-3801	16	7	the	the	DET
fnp-3801	16	8	10	10	NUM
fnp-3801	16	9	most	most	ADV
fnp-3801	16	10	interesting	interesting	ADJ
fnp-3801	16	11	discoveries	discovery	NOUN
fnp-3801	16	12	in	in	ADP
fnp-3801	16	13	the	the	DET
fnp-3801	16	14	field	field	NOUN
fnp-3801	16	15	during	during	ADP
fnp-3801	16	16	the	the	DET
fnp-3801	16	17	last	last	ADJ
fnp-3801	16	18	year	year	NOUN
fnp-3801	16	19	.	.	PUNCT
fnp-3801	17	1	instead	instead	ADV
fnp-3801	17	2	of	of	ADP
fnp-3801	17	3	centering	center	VERB
fnp-3801	17	4	our	our	PRON
fnp-3801	17	5	efforts	effort	NOUN
fnp-3801	17	6	around	around	ADP
fnp-3801	17	7	papers	paper	NOUN
fnp-3801	17	8	published	publish	VERB
fnp-3801	17	9	in	in	ADP
fnp-3801	17	10	the	the	DET
fnp-3801	17	11	highest	high	ADJ
fnp-3801	17	12	impact	impact	NOUN
fnp-3801	17	13	factor	factor	NOUN
fnp-3801	17	14	journals	journal	NOUN
fnp-3801	17	15	,	,	PUNCT
fnp-3801	17	16	we	we	PRON
fnp-3801	17	17	decided	decide	VERB
fnp-3801	17	18	to	to	PART
fnp-3801	17	19	select	select	VERB
fnp-3801	17	20	the	the	DET
fnp-3801	17	21	discoveries	discovery	NOUN
fnp-3801	17	22	that	that	PRON
fnp-3801	17	23	open	open	VERB
fnp-3801	17	24	new	new	ADJ
fnp-3801	17	25	research	research	NOUN
fnp-3801	17	26	avenues	avenue	NOUN
fnp-3801	17	27	and	and	CCONJ
fnp-3801	17	28	that	that	PRON
fnp-3801	17	29	can	can	AUX
fnp-3801	17	30	be	be	AUX
fnp-3801	17	31	expected	expect	VERB
fnp-3801	17	32	to	to	PART
fnp-3801	17	33	have	have	VERB
fnp-3801	17	34	substantial	substantial	ADJ
fnp-3801	17	35	implications	implication	NOUN
fnp-3801	17	36	in	in	ADP
fnp-3801	17	37	the	the	DET
fnp-3801	17	38	study	study	NOUN
fnp-3801	17	39	of	of	ADP
fnp-3801	17	40	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	17	41	disorders	disorder	NOUN
fnp-3801	17	42	paving	pave	VERB
fnp-3801	17	43	the	the	DET
fnp-3801	17	44	way	way	NOUN
fnp-3801	17	45	to	to	ADP
fnp-3801	17	46	a	a	DET
fnp-3801	17	47	change	change	NOUN
fnp-3801	17	48	of	of	ADP
fnp-3801	17	49	paradigms	paradigm	NOUN
fnp-3801	17	50	.	.	PUNCT
fnp-3801	18	1	the	the	DET
fnp-3801	18	2	major	major	ADJ
fnp-3801	18	3	steps	step	NOUN
fnp-3801	18	4	made	make	VERB
fnp-3801	18	5	during	during	ADP
fnp-3801	18	6	2021	2021	NUM
fnp-3801	18	7	comprise	comprise	VERB
fnp-3801	18	8	very	very	ADV
fnp-3801	18	9	different	different	ADJ
fnp-3801	18	10	topics	topic	NOUN
fnp-3801	18	11	,	,	PUNCT
fnp-3801	18	12	from	from	ADP
fnp-3801	18	13	the	the	DET
fnp-3801	18	14	discovery	discovery	NOUN
fnp-3801	18	15	of	of	ADP
fnp-3801	18	16	new	new	ADJ
fnp-3801	18	17	shared	share	VERB
fnp-3801	18	18	molecular	molecular	ADJ
fnp-3801	18	19	mechanisms	mechanism	NOUN
fnp-3801	18	20	involved	involve	VERB
fnp-3801	18	21	in	in	ADP
fnp-3801	18	22	several	several	ADJ
fnp-3801	18	23	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	18	24	syndromes	syndrome	NOUN
fnp-3801	18	25	such	such	ADJ
fnp-3801	18	26	as	as	ADP
fnp-3801	18	27	aicardi	aicardi	NOUN
fnp-3801	18	28	-	-	PUNCT
fnp-3801	18	29	goutières	goutière	NOUN
fnp-3801	18	30	syndrome	syndrome	NOUN
fnp-3801	18	31	or	or	CCONJ
fnp-3801	18	32	coffin	coffin	NOUN
fnp-3801	18	33	-	-	PUNCT
fnp-3801	18	34	siris	siris	NOUN
fnp-3801	18	35	to	to	ADP
fnp-3801	18	36	disentangling	disentangle	VERB
fnp-3801	18	37	the	the	DET
fnp-3801	18	38	complexity	complexity	NOUN
fnp-3801	18	39	of	of	ADP
fnp-3801	18	40	autism	autism	NOUN
fnp-3801	18	41	spectrum	spectrum	NOUN
fnp-3801	18	42	disorders	disorder	NOUN
fnp-3801	18	43	by	by	ADP
fnp-3801	18	44	the	the	DET
fnp-3801	18	45	identification	identification	NOUN
fnp-3801	18	46	of	of	ADP
fnp-3801	18	47	new	new	ADJ
fnp-3801	18	48	players	player	NOUN
fnp-3801	18	49	at	at	ADP
fnp-3801	18	50	the	the	DET
fnp-3801	18	51	network	network	NOUN
fnp-3801	18	52	,	,	PUNCT
fnp-3801	18	53	on	on	ADP
fnp-3801	18	54	the	the	DET
fnp-3801	18	55	cellular	cellular	NOUN
fnp-3801	18	56	and	and	CCONJ
fnp-3801	18	57	the	the	DET
fnp-3801	18	58	molecular	molecular	ADJ
fnp-3801	18	59	levels	level	NOUN
fnp-3801	18	60	.	.	PUNCT
fnp-3801	19	1	advancement	advancement	NOUN
fnp-3801	19	2	in	in	ADP
fnp-3801	19	3	modeling	model	VERB
fnp-3801	19	4	tools	tool	NOUN
fnp-3801	19	5	holds	hold	VERB
fnp-3801	19	6	the	the	DET
fnp-3801	19	7	promise	promise	NOUN
fnp-3801	19	8	to	to	PART
fnp-3801	19	9	not	not	PART
fnp-3801	19	10	only	only	ADV
fnp-3801	19	11	increase	increase	VERB
fnp-3801	19	12	our	our	PRON
fnp-3801	19	13	understanding	understanding	NOUN
fnp-3801	19	14	of	of	ADP
fnp-3801	19	15	the	the	DET
fnp-3801	19	16	origin	origin	NOUN
fnp-3801	19	17	of	of	ADP
fnp-3801	19	18	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	19	19	disorders	disorder	NOUN
fnp-3801	19	20	,	,	PUNCT
fnp-3801	19	21	including	include	VERB
fnp-3801	19	22	their	their	PRON
fnp-3801	19	23	evolutionary	evolutionary	ADJ
fnp-3801	19	24	aspects	aspect	NOUN
fnp-3801	19	25	,	,	PUNCT
fnp-3801	19	26	but	but	CCONJ
fnp-3801	19	27	also	also	ADV
fnp-3801	19	28	to	to	PART
fnp-3801	19	29	start	start	VERB
fnp-3801	19	30	proving	prove	VERB
fnp-3801	19	31	causality	causality	NOUN
fnp-3801	19	32	.	.	PUNCT
fnp-3801	20	1	in	in	ADP
fnp-3801	20	2	the	the	DET
fnp-3801	20	3	last	last	ADJ
fnp-3801	20	4	year	year	NOUN
fnp-3801	20	5	,	,	PUNCT
fnp-3801	20	6	the	the	DET
fnp-3801	20	7	role	role	NOUN
fnp-3801	20	8	of	of	ADP
fnp-3801	20	9	several	several	ADJ
fnp-3801	20	10	underexplored	underexplored	ADJ
fnp-3801	20	11	biological	biological	ADJ
fnp-3801	20	12	underpinnings	underpinning	NOUN
fnp-3801	20	13	such	such	ADJ
fnp-3801	20	14	as	as	ADP
fnp-3801	20	15	trnas	trnas	NOUN
fnp-3801	20	16	methylation	methylation	NOUN
fnp-3801	20	17	or	or	CCONJ
fnp-3801	20	18	mitochondrial	mitochondrial	ADJ
fnp-3801	20	19	-	-	PUNCT
fnp-3801	20	20	derived	derive	VERB
fnp-3801	20	21	extracellular	extracellular	ADJ
fnp-3801	20	22	vesicles	vesicle	NOUN
fnp-3801	20	23	were	be	AUX
fnp-3801	20	24	clarified	clarify	VERB
fnp-3801	20	25	in	in	ADP
fnp-3801	20	26	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	20	27	disorders	disorder	NOUN
fnp-3801	20	28	,	,	PUNCT
fnp-3801	20	29	opening	open	VERB
fnp-3801	20	30	new	new	ADJ
fnp-3801	20	31	perspectives	perspective	NOUN
fnp-3801	20	32	for	for	ADP
fnp-3801	20	33	diagnosis	diagnosis	NOUN
fnp-3801	20	34	and	and	CCONJ
fnp-3801	20	35	treatment	treatment	NOUN
fnp-3801	20	36	.	.	PUNCT
fnp-3801	21	1	finally	finally	ADV
fnp-3801	21	2	,	,	PUNCT
fnp-3801	21	3	new	new	ADJ
fnp-3801	21	4	tools	tool	NOUN
fnp-3801	21	5	appeared	appear	VERB
fnp-3801	21	6	to	to	PART
fnp-3801	21	7	study	study	VERB
fnp-3801	21	8	human	human	ADJ
fnp-3801	21	9	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	21	10	disorders	disorder	NOUN
fnp-3801	21	11	,	,	PUNCT
fnp-3801	21	12	partially	partially	ADV
fnp-3801	21	13	solving	solve	VERB
fnp-3801	21	14	some	some	PRON
fnp-3801	21	15	of	of	ADP
fnp-3801	21	16	the	the	DET
fnp-3801	21	17	associated	associated	ADJ
fnp-3801	21	18	problems	problem	NOUN
fnp-3801	21	19	with	with	ADP
fnp-3801	21	20	the	the	DET
fnp-3801	21	21	use	use	NOUN
fnp-3801	21	22	of	of	ADP
fnp-3801	21	23	animal	animal	NOUN
fnp-3801	21	24	models	model	NOUN
fnp-3801	21	25	.	.	PUNCT
fnp-3801	22	1	the	the	DET
fnp-3801	22	2	final	final	ADJ
fnp-3801	22	3	list	list	NOUN
fnp-3801	22	4	of	of	ADP
fnp-3801	22	5	papers	paper	NOUN
fnp-3801	22	6	and	and	CCONJ
fnp-3801	22	7	topics	topic	NOUN
fnp-3801	22	8	of	of	ADP
fnp-3801	22	9	2021	2021	NUM
fnp-3801	22	10	,	,	PUNCT
fnp-3801	22	11	selected	select	VERB
fnp-3801	22	12	as	as	ADP
fnp-3801	22	13	very	very	ADV
fnp-3801	22	14	interesting	interesting	ADJ
fnp-3801	22	15	and/or	and/or	CCONJ
fnp-3801	22	16	important	important	ADJ
fnp-3801	22	17	for	for	ADP
fnp-3801	22	18	the	the	DET
fnp-3801	22	19	field	field	NOUN
fnp-3801	22	20	of	of	ADP
fnp-3801	22	21	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	22	22	disorders	disorder	NOUN
fnp-3801	22	23	,	,	PUNCT
fnp-3801	22	24	comprises	comprise	NOUN
fnp-3801	22	25	:	:	PUNCT
fnp-3801	22	26	reconsidering	reconsider	VERB
fnp-3801	22	27	the	the	DET
fnp-3801	22	28	molecular	molecular	ADJ
fnp-3801	22	29	neuropathological	neuropathological	ADJ
fnp-3801	22	30	basis	basis	NOUN
fnp-3801	22	31	of	of	ADP
fnp-3801	22	32	aicardi	aicardi	NOUN
fnp-3801	22	33	-	-	PUNCT
fnp-3801	22	34	goutières	goutière	NOUN
fnp-3801	22	35	syndrome	syndrome	NOUN
fnp-3801	22	36	(	(	PUNCT
fnp-3801	22	37	ags	ag	NOUN
fnp-3801	22	38	)	)	PUNCT
fnp-3801	22	39	.	.	PUNCT
fnp-3801	23	1	understanding	understand	VERB
fnp-3801	23	2	cortical	cortical	ADJ
fnp-3801	23	3	neurodevelopment	neurodevelopment	ADJ
fnp-3801	23	4	from	from	ADP
fnp-3801	23	5	evolution	evolution	NOUN
fnp-3801	23	6	.	.	PUNCT
fnp-3801	24	1	new	new	ADJ
fnp-3801	24	2	3d	3d	PROPN
fnp-3801	24	3	in	in	ADP
fnp-3801	24	4	vitro	vitro	X
fnp-3801	24	5	models	model	NOUN
fnp-3801	24	6	to	to	PART
fnp-3801	24	7	unveil	unveil	VERB
fnp-3801	24	8	neuropathological	neuropathological	ADJ
fnp-3801	24	9	mechanisms	mechanism	NOUN
fnp-3801	24	10	of	of	ADP
fnp-3801	24	11	human	human	ADJ
fnp-3801	24	12	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	24	13	disorders	disorder	NOUN
fnp-3801	24	14	.	.	PUNCT
fnp-3801	25	1	new	new	ADJ
fnp-3801	25	2	insights	insight	NOUN
fnp-3801	25	3	and	and	CCONJ
fnp-3801	25	4	tools	tool	NOUN
fnp-3801	25	5	to	to	PART
fnp-3801	25	6	explore	explore	VERB
fnp-3801	25	7	the	the	DET
fnp-3801	25	8	genome	genome	NOUN
fnp-3801	25	9	architecture	architecture	NOUN
fnp-3801	25	10	and	and	CCONJ
fnp-3801	25	11	transcriptional	transcriptional	ADJ
fnp-3801	25	12	dynamics	dynamic	NOUN
fnp-3801	25	13	in	in	ADP
fnp-3801	25	14	the	the	DET
fnp-3801	25	15	mammalian	mammalian	ADJ
fnp-3801	25	16	brain	brain	NOUN
fnp-3801	25	17	development	development	NOUN
fnp-3801	25	18	.	.	PUNCT
fnp-3801	26	1	new	new	ADJ
fnp-3801	26	2	cellular	cellular	ADJ
fnp-3801	26	3	mechanisms	mechanism	NOUN
fnp-3801	26	4	and	and	CCONJ
fnp-3801	26	5	new	new	ADJ
fnp-3801	26	6	tools	tool	NOUN
fnp-3801	26	7	to	to	PART
fnp-3801	26	8	establish	establish	VERB
fnp-3801	26	9	causality	causality	NOUN
fnp-3801	26	10	in	in	ADP
fnp-3801	26	11	asd	asd	PROPN
fnp-3801	26	12	.	.	PUNCT
fnp-3801	27	1	new	new	ADJ
fnp-3801	27	2	mechanism	mechanism	NOUN
fnp-3801	27	3	in	in	ADP
fnp-3801	27	4	asd	asd	PROPN
fnp-3801	27	5	pathology	pathology	PROPN
fnp-3801	27	6	:	:	PUNCT
fnp-3801	27	7	astrocytes	astrocyte	NOUN
fnp-3801	27	8	,	,	PUNCT
fnp-3801	27	9	atp	atp	PROPN
fnp-3801	27	10	and	and	CCONJ
fnp-3801	27	11	gabaergic	gabaergic	ADJ
fnp-3801	27	12	signaling	signaling	NOUN
fnp-3801	27	13	.	.	PUNCT
fnp-3801	28	1	disentangling	disentangle	VERB
fnp-3801	28	2	the	the	DET
fnp-3801	28	3	role	role	NOUN
fnp-3801	28	4	of	of	ADP
fnp-3801	28	5	repeatome	repeatome	NOUN
fnp-3801	28	6	in	in	ADP
fnp-3801	28	7	asd	asd	PROPN
fnp-3801	28	8	.	.	PUNCT
fnp-3801	29	1	key	key	ADJ
fnp-3801	29	2	switch	switch	NOUN
fnp-3801	29	3	between	between	ADP
fnp-3801	29	4	chromatin	chromatin	NOUN
fnp-3801	29	5	remodeler	remodel	ADJ
fnp-3801	29	6	baf	baf	PROPN
fnp-3801	29	7	subunits	subunit	NOUN
fnp-3801	29	8	explains	explain	VERB
fnp-3801	29	9	coffin	coffin	NOUN
fnp-3801	29	10	-	-	PUNCT
fnp-3801	29	11	siris	siris	NOUN
fnp-3801	29	12	syndrome	syndrome	PROPN
fnp-3801	29	13	neuropathology	neuropathology	PROPN
fnp-3801	29	14	.	.	PUNCT
fnp-3801	30	1	trnas	trnas	PROPN
fnp-3801	30	2	methylation	methylation	NOUN
fnp-3801	30	3	and	and	CCONJ
fnp-3801	30	4	intellectual	intellectual	ADJ
fnp-3801	30	5	disability	disability	NOUN
fnp-3801	30	6	.	.	PUNCT
fnp-3801	31	1	mitovesicles	mitovesicle	NOUN
fnp-3801	31	2	:	:	PUNCT
fnp-3801	31	3	a	a	DET
fnp-3801	31	4	new	new	ADJ
fnp-3801	31	5	player	player	NOUN
fnp-3801	31	6	in	in	ADP
fnp-3801	31	7	the	the	DET
fnp-3801	31	8	neuropathology	neuropathology	NOUN
fnp-3801	31	9	of	of	ADP
fnp-3801	31	10	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	31	11	disorders	disorder	NOUN
fnp-3801	31	12	.	.	PUNCT
fnp-3801	32	1	reconsidering	reconsider	VERB
fnp-3801	32	2	the	the	DET
fnp-3801	32	3	molecular	molecular	ADJ
fnp-3801	32	4	neuropathological	neuropathological	ADJ
fnp-3801	32	5	basis	basis	NOUN
fnp-3801	32	6	of	of	ADP
fnp-3801	32	7	aicardi	aicardi	NOUN
fnp-3801	32	8	-	-	PUNCT
fnp-3801	32	9	goutières	goutière	NOUN
fnp-3801	32	10	syndrome	syndrome	NOUN
fnp-3801	32	11	(	(	PUNCT
fnp-3801	32	12	ags	ag	NOUN
fnp-3801	32	13	)	)	PUNCT
fnp-3801	32	14	aicardi	aicardi	NOUN
fnp-3801	32	15	-	-	PUNCT
fnp-3801	32	16	goutières	goutière	NOUN
fnp-3801	32	17	syndrome	syndrome	NOUN
fnp-3801	32	18	(	(	PUNCT
fnp-3801	32	19	ags	ag	NOUN
fnp-3801	32	20	)	)	PUNCT
fnp-3801	32	21	is	be	AUX
fnp-3801	32	22	a	a	DET
fnp-3801	32	23	rare	rare	ADJ
fnp-3801	32	24	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	32	25	disorder	disorder	NOUN
fnp-3801	32	26	.	.	PUNCT
fnp-3801	33	1	the	the	DET
fnp-3801	33	2	main	main	ADJ
fnp-3801	33	3	neuropathological	neuropathological	ADJ
fnp-3801	33	4	signs	sign	NOUN
fnp-3801	33	5	are	be	AUX
fnp-3801	33	6	progressive	progressive	ADJ
fnp-3801	33	7	microcephaly	microcephaly	NOUN
fnp-3801	33	8	associated	associate	VERB
fnp-3801	33	9	with	with	ADP
fnp-3801	33	10	basal	basal	ADJ
fnp-3801	33	11	ganglia	ganglion	NOUN
fnp-3801	33	12	and	and	CCONJ
fnp-3801	33	13	white	white	ADJ
fnp-3801	33	14	matter	matter	NOUN
fnp-3801	33	15	calcifications	calcification	NOUN
fnp-3801	33	16	,	,	PUNCT
fnp-3801	33	17	leukodystrophy	leukodystrophy	NOUN
fnp-3801	33	18	,	,	PUNCT
fnp-3801	33	19	cerebral	cerebral	ADJ
fnp-3801	33	20	atrophy	atrophy	NOUN
fnp-3801	33	21	,	,	PUNCT
fnp-3801	33	22	and	and	CCONJ
fnp-3801	33	23	variable	variable	ADJ
fnp-3801	33	24	increase	increase	NOUN
fnp-3801	33	25	of	of	ADP
fnp-3801	33	26	lymphocyte	lymphocyte	ADJ
fnp-3801	33	27	count	count	NOUN
fnp-3801	33	28	in	in	ADP
fnp-3801	33	29	the	the	DET
fnp-3801	33	30	cerebrospinal	cerebrospinal	ADJ
fnp-3801	33	31	fluid	fluid	NOUN
fnp-3801	33	32	.	.	PUNCT
fnp-3801	34	1	it	it	PRON
fnp-3801	34	2	is	be	AUX
fnp-3801	34	3	caused	cause	VERB
fnp-3801	34	4	by	by	ADP
fnp-3801	34	5	recessive	recessive	ADJ
fnp-3801	34	6	mutations	mutation	NOUN
fnp-3801	34	7	in	in	ADP
fnp-3801	34	8	nine	nine	NUM
fnp-3801	34	9	known	know	VERB
fnp-3801	34	10	genes	gene	NOUN
fnp-3801	34	11	identified	identify	VERB
fnp-3801	34	12	until	until	ADP
fnp-3801	34	13	now	now	ADV
fnp-3801	34	14	,	,	PUNCT
fnp-3801	34	15	namely	namely	ADV
fnp-3801	34	16	trex1	trex1	NOUN
fnp-3801	34	17	,	,	PUNCT
fnp-3801	34	18	rnaseh2a	rnaseh2a	PROPN
fnp-3801	34	19	,	,	PUNCT
fnp-3801	34	20	rnaseh2b	rnaseh2b	PROPN
fnp-3801	34	21	,	,	PUNCT
fnp-3801	34	22	rnaseh2c	rnaseh2c	PROPN
fnp-3801	34	23	,	,	PUNCT
fnp-3801	34	24	samhd1	samhd1	PROPN
fnp-3801	34	25	,	,	PUNCT
fnp-3801	34	26	adar1	adar1	PROPN
fnp-3801	34	27	,	,	PUNCT
fnp-3801	34	28	mda5	mda5	PROPN
fnp-3801	34	29	,	,	PUNCT
fnp-3801	34	30	lsm11	lsm11	PROPN
fnp-3801	34	31	and	and	CCONJ
fnp-3801	34	32	rnu7	rnu7	PROPN
fnp-3801	34	33	-	-	PUNCT
fnp-3801	34	34	1	1	NUM
fnp-3801	34	35	that	that	PRON
fnp-3801	34	36	result	result	VERB
fnp-3801	34	37	in	in	ADP
fnp-3801	34	38	upregulation	upregulation	NOUN
fnp-3801	34	39	of	of	ADP
fnp-3801	34	40	type	type	NOUN
fnp-3801	34	41	i	i	PRON
fnp-3801	34	42	interferon	interferon	ADJ
fnp-3801	34	43	(	(	PUNCT
fnp-3801	34	44	ifn	ifn	PROPN
fnp-3801	34	45	)	)	PUNCT
fnp-3801	34	46	signaling	signal	VERB
fnp-3801	34	47	and	and	CCONJ
fnp-3801	34	48	is	be	AUX
fnp-3801	34	49	accompanied	accompany	VERB
fnp-3801	34	50	by	by	ADP
fnp-3801	34	51	neuroinflammation	neuroinflammation	NOUN
fnp-3801	34	52	[	[	X
fnp-3801	34	53	1	1	NUM
fnp-3801	34	54	]	]	PUNCT
fnp-3801	34	55	.	.	PUNCT
fnp-3801	35	1	increased	increase	VERB
fnp-3801	35	2	type	type	NOUN
fnp-3801	35	3	i	i	PRON
fnp-3801	35	4	ifn	ifn	NOUN
fnp-3801	35	5	activity	activity	NOUN
fnp-3801	35	6	is	be	AUX
fnp-3801	35	7	detected	detect	VERB
fnp-3801	35	8	in	in	ADP
fnp-3801	35	9	cerebrospinal	cerebrospinal	ADJ
fnp-3801	35	10	fluid	fluid	NOUN
fnp-3801	35	11	and	and	CCONJ
fnp-3801	35	12	serum	serum	NOUN
fnp-3801	35	13	,	,	PUNCT
fnp-3801	35	14	and	and	CCONJ
fnp-3801	35	15	increased	increase	VERB
fnp-3801	35	16	expression	expression	NOUN
fnp-3801	35	17	of	of	ADP
fnp-3801	35	18	ifn	ifn	NOUN
fnp-3801	35	19	-	-	PUNCT
fnp-3801	35	20	stimulated	stimulate	VERB
fnp-3801	35	21	gene	gene	NOUN
fnp-3801	35	22	transcripts	transcript	NOUN
fnp-3801	35	23	in	in	ADP
fnp-3801	35	24	peripheral	peripheral	ADJ
fnp-3801	35	25	blood	blood	NOUN
fnp-3801	35	26	.	.	PUNCT
fnp-3801	36	1	moreover	moreover	ADV
fnp-3801	36	2	,	,	PUNCT
fnp-3801	36	3	a	a	DET
fnp-3801	36	4	positive	positive	ADJ
fnp-3801	36	5	correlation	correlation	NOUN
fnp-3801	36	6	between	between	ADP
fnp-3801	36	7	the	the	DET
fnp-3801	36	8	level	level	NOUN
fnp-3801	36	9	of	of	ADP
fnp-3801	36	10	cerebrospinal	cerebrospinal	ADJ
fnp-3801	36	11	fluid	fluid	ADJ
fnp-3801	36	12	ifn	ifn	NOUN
fnp-3801	36	13	activity	activity	NOUN
fnp-3801	36	14	and	and	CCONJ
fnp-3801	36	15	the	the	DET
fnp-3801	36	16	degree	degree	NOUN
fnp-3801	36	17	of	of	ADP
fnp-3801	36	18	motor	motor	NOUN
fnp-3801	36	19	and	and	CCONJ
fnp-3801	36	20	intellectual	intellectual	ADJ
fnp-3801	36	21	disability	disability	NOUN
fnp-3801	36	22	has	have	AUX
fnp-3801	36	23	been	be	AUX
fnp-3801	36	24	reported	report	VERB
fnp-3801	36	25	[	[	PUNCT
fnp-3801	36	26	2	2	NUM
fnp-3801	36	27	]	]	PUNCT
fnp-3801	36	28	.	.	PUNCT
fnp-3801	37	1	astrocytes	astrocyte	NOUN
fnp-3801	37	2	are	be	AUX
fnp-3801	37	3	the	the	DET
fnp-3801	37	4	main	main	ADJ
fnp-3801	37	5	cell	cell	NOUN
fnp-3801	37	6	type	type	NOUN
fnp-3801	37	7	that	that	PRON
fnp-3801	37	8	produce	produce	VERB
fnp-3801	37	9	ifn	ifn	PROPN
fnp-3801	37	10	-	-	PUNCT
fnp-3801	37	11	α	α	NOUN
fnp-3801	37	12	in	in	ADP
fnp-3801	37	13	the	the	DET
fnp-3801	37	14	brain	brain	NOUN
fnp-3801	37	15	and	and	CCONJ
fnp-3801	37	16	magnetic	magnetic	ADJ
fnp-3801	37	17	resonance	resonance	NOUN
fnp-3801	37	18	image	image	NOUN
fnp-3801	37	19	studies	study	NOUN
fnp-3801	37	20	in	in	ADP
fnp-3801	37	21	patients	patient	NOUN
fnp-3801	37	22	suffering	suffer	VERB
fnp-3801	37	23	ags	ag	NOUN
fnp-3801	37	24	show	show	VERB
fnp-3801	37	25	calcifications	calcification	NOUN
fnp-3801	37	26	in	in	ADP
fnp-3801	37	27	the	the	DET
fnp-3801	37	28	white	white	ADJ
fnp-3801	37	29	matter	matter	NOUN
fnp-3801	37	30	and	and	CCONJ
fnp-3801	37	31	white	white	ADJ
fnp-3801	37	32	matter	matter	NOUN
fnp-3801	37	33	signal	signal	NOUN
fnp-3801	37	34	changes	change	NOUN
fnp-3801	37	35	in	in	ADP
fnp-3801	37	36	the	the	DET
fnp-3801	37	37	frontotemporal	frontotemporal	ADJ
fnp-3801	37	38	regions	region	NOUN
fnp-3801	37	39	with	with	ADP
fnp-3801	37	40	associated	associated	ADJ
fnp-3801	37	41	astrocytosis	astrocytosis	NOUN
fnp-3801	37	42	[	[	X
fnp-3801	37	43	3	3	NUM
fnp-3801	37	44	]	]	PUNCT
fnp-3801	37	45	.	.	PUNCT
fnp-3801	38	1	interestingly	interestingly	ADV
fnp-3801	38	2	,	,	PUNCT
fnp-3801	38	3	ags	ag	NOUN
fnp-3801	38	4	-	-	PUNCT
fnp-3801	38	5	related	relate	VERB
fnp-3801	38	6	genes	gene	NOUN
fnp-3801	38	7	are	be	AUX
fnp-3801	38	8	critical	critical	ADJ
fnp-3801	38	9	in	in	ADP
fnp-3801	38	10	nucleic	nucleic	ADJ
fnp-3801	38	11	acid	acid	NOUN
fnp-3801	38	12	metabolism	metabolism	NOUN
fnp-3801	38	13	function	function	NOUN
fnp-3801	38	14	[	[	X
fnp-3801	38	15	4	4	NUM
fnp-3801	38	16	,	,	PUNCT
fnp-3801	38	17	5	5	NUM
fnp-3801	38	18	]	]	PUNCT
fnp-3801	38	19	,	,	PUNCT
fnp-3801	38	20	and	and	CCONJ
fnp-3801	38	21	involved	involve	VERB
fnp-3801	38	22	in	in	ADP
fnp-3801	38	23	the	the	DET
fnp-3801	38	24	removal	removal	NOUN
fnp-3801	38	25	of	of	ADP
fnp-3801	38	26	redundant	redundant	ADJ
fnp-3801	38	27	endogenous	endogenous	ADJ
fnp-3801	38	28	or	or	CCONJ
fnp-3801	38	29	exogenous	exogenous	ADJ
fnp-3801	38	30	dna	dna	NOUN
fnp-3801	38	31	,	,	PUNCT
fnp-3801	38	32	rna	rna	NOUN
fnp-3801	38	33	,	,	PUNCT
fnp-3801	38	34	or	or	CCONJ
fnp-3801	38	35	dna	dna	PROPN
fnp-3801	38	36	/	/	SYM
fnp-3801	38	37	rna	rna	NOUN
fnp-3801	38	38	hybrids	hybrid	NOUN
fnp-3801	38	39	.	.	PUNCT
fnp-3801	39	1	it	it	PRON
fnp-3801	39	2	is	be	AUX
fnp-3801	39	3	assumed	assume	VERB
fnp-3801	39	4	that	that	SCONJ
fnp-3801	39	5	failure	failure	NOUN
fnp-3801	39	6	to	to	PART
fnp-3801	39	7	remove	remove	VERB
fnp-3801	39	8	intracellular	intracellular	ADJ
fnp-3801	39	9	remnants	remnant	NOUN
fnp-3801	39	10	of	of	ADP
fnp-3801	39	11	nucleic	nucleic	ADJ
fnp-3801	39	12	acids	acid	NOUN
fnp-3801	39	13	leads	lead	VERB
fnp-3801	39	14	to	to	ADP
fnp-3801	39	15	stimulation	stimulation	NOUN
fnp-3801	39	16	of	of	ADP
fnp-3801	39	17	the	the	DET
fnp-3801	39	18	innate	innate	ADJ
fnp-3801	39	19	and	and	CCONJ
fnp-3801	39	20	adaptive	adaptive	ADJ
fnp-3801	39	21	immune	immune	ADJ
fnp-3801	39	22	responses	response	NOUN
fnp-3801	39	23	,	,	PUNCT
fnp-3801	39	24	so	so	SCONJ
fnp-3801	39	25	that	that	DET
fnp-3801	39	26	type	type	NOUN
fnp-3801	39	27	i	i	PRON
fnp-3801	39	28	interferonopathies	interferonopathie	NOUN
fnp-3801	39	29	would	would	AUX
fnp-3801	39	30	represent	represent	VERB
fnp-3801	39	31	a	a	DET
fnp-3801	39	32	failure	failure	NOUN
fnp-3801	39	33	of	of	ADP
fnp-3801	39	34	selfversus	selfversus	NOUN
fnp-3801	39	35	non	non	ADJ
fnp-3801	39	36	-	-	ADJ
fnp-3801	39	37	self	self	NOUN
fnp-3801	39	38	-	-	PUNCT
fnp-3801	39	39	discrimination	discrimination	NOUN
fnp-3801	39	40	,	,	PUNCT
fnp-3801	39	41	as	as	SCONJ
fnp-3801	39	42	these	these	DET
fnp-3801	39	43	essential	essential	ADJ
fnp-3801	39	44	antiviral	antiviral	ADJ
fnp-3801	39	45	systems	system	NOUN
fnp-3801	39	46	can	can	AUX
fnp-3801	39	47	also	also	ADV
fnp-3801	39	48	be	be	AUX
fnp-3801	39	49	triggered	trigger	VERB
fnp-3801	39	50	by	by	ADP
fnp-3801	39	51	host	host	NOUN
fnp-3801	39	52	dna	dna	NOUN
fnp-3801	39	53	and	and	CCONJ
fnp-3801	39	54	rna	rna	PROPN
fnp-3801	39	55	.	.	PUNCT
fnp-3801	40	1	the	the	DET
fnp-3801	40	2	ribonuclease	ribonuclease	NOUN
fnp-3801	40	3	h2	h2	NOUN
fnp-3801	40	4	(	(	PUNCT
fnp-3801	40	5	rnaseh2	rnaseh2	NOUN
fnp-3801	40	6	)	)	PUNCT
fnp-3801	40	7	,	,	PUNCT
fnp-3801	40	8	linked	link	VERB
fnp-3801	40	9	to	to	ADP
fnp-3801	40	10	ags	ag	NOUN
fnp-3801	40	11	,	,	PUNCT
fnp-3801	40	12	is	be	AUX
fnp-3801	40	13	a	a	DET
fnp-3801	40	14	genome	genome	NOUN
fnp-3801	40	15	surveillance	surveillance	NOUN
fnp-3801	40	16	factor	factor	NOUN
fnp-3801	40	17	,	,	PUNCT
fnp-3801	40	18	which	which	PRON
fnp-3801	40	19	has	have	VERB
fnp-3801	40	20	the	the	DET
fnp-3801	40	21	role	role	NOUN
fnp-3801	40	22	of	of	ADP
fnp-3801	40	23	constantly	constantly	ADV
fnp-3801	40	24	inspecting	inspect	VERB
fnp-3801	40	25	dna	dna	PROPN
fnp-3801	40	26	integrity	integrity	NOUN
fnp-3801	40	27	and	and	CCONJ
fnp-3801	40	28	removing	remove	VERB
fnp-3801	40	29	ribonucleotides	ribonucleotide	NOUN
fnp-3801	40	30	that	that	SCONJ
fnp-3801	40	31	incorporate	incorporate	VERB
fnp-3801	40	32	by	by	ADP
fnp-3801	40	33	error	error	NOUN
fnp-3801	40	34	into	into	ADP
fnp-3801	40	35	replicating	replicate	VERB
fnp-3801	40	36	dna	dna	NOUN
fnp-3801	40	37	[	[	X
fnp-3801	40	38	2	2	NUM
fnp-3801	40	39	]	]	PUNCT
fnp-3801	40	40	.	.	PUNCT
fnp-3801	41	1	however	however	ADV
fnp-3801	41	2	,	,	PUNCT
fnp-3801	41	3	the	the	DET
fnp-3801	41	4	role	role	NOUN
fnp-3801	41	5	of	of	ADP
fnp-3801	41	6	ifn	ifn	PROPN
fnp-3801	41	7	hyperactivity	hyperactivity	NOUN
fnp-3801	41	8	and	and	CCONJ
fnp-3801	41	9	rnaseh2	rnaseh2	NOUN
fnp-3801	41	10	mutations	mutation	NOUN
fnp-3801	41	11	and	and	CCONJ
fnp-3801	41	12	their	their	PRON
fnp-3801	41	13	possible	possible	ADJ
fnp-3801	41	14	functional	functional	ADJ
fnp-3801	41	15	interaction	interaction	NOUN
fnp-3801	41	16	on	on	ADP
fnp-3801	41	17	ags	ag	NOUN
fnp-3801	41	18	neuropathology	neuropathology	NOUN
fnp-3801	41	19	is	be	AUX
fnp-3801	41	20	poorly	poorly	ADV
fnp-3801	41	21	understood	understand	VERB
fnp-3801	41	22	.	.	PUNCT
fnp-3801	42	1	although	although	SCONJ
fnp-3801	42	2	the	the	DET
fnp-3801	42	3	neurotoxic	neurotoxic	ADJ
fnp-3801	42	4	potential	potential	NOUN
fnp-3801	42	5	of	of	ADP
fnp-3801	42	6	type	type	NOUN
fnp-3801	42	7	i	i	PRON
fnp-3801	42	8	ifn	ifn	VERB
fnp-3801	42	9	was	be	AUX
fnp-3801	42	10	highlighted	highlight	VERB
fnp-3801	42	11	by	by	ADP
fnp-3801	42	12	studies	study	NOUN
fnp-3801	42	13	that	that	PRON
fnp-3801	42	14	recapitulated	recapitulate	VERB
fnp-3801	42	15	the	the	DET
fnp-3801	42	16	neuropathological	neuropathological	ADJ
fnp-3801	42	17	features	feature	NOUN
fnp-3801	42	18	of	of	ADP
fnp-3801	42	19	ags	ag	NOUN
fnp-3801	42	20	in	in	ADP
fnp-3801	42	21	transgenic	transgenic	NOUN
fnp-3801	42	22	mice	mouse	NOUN
fnp-3801	42	23	chronically	chronically	ADV
fnp-3801	42	24	producing	produce	VERB
fnp-3801	42	25	ifn	ifn	PROPN
fnp-3801	42	26	-	-	PUNCT
fnp-3801	42	27	α	α	NOUN
fnp-3801	42	28	from	from	ADP
fnp-3801	42	29	astrocytes	astrocyte	NOUN
fnp-3801	42	30	[	[	X
fnp-3801	42	31	6	6	NUM
fnp-3801	42	32	]	]	PUNCT
fnp-3801	42	33	,	,	PUNCT
fnp-3801	42	34	available	available	ADJ
fnp-3801	42	35	genetic	genetic	ADJ
fnp-3801	42	36	ags	ag	NOUN
fnp-3801	42	37	mouse	mouse	NOUN
fnp-3801	42	38	models	model	NOUN
fnp-3801	42	39	fail	fail	VERB
fnp-3801	42	40	to	to	PART
fnp-3801	42	41	show	show	VERB
fnp-3801	42	42	type	type	NOUN
fnp-3801	42	43	i	i	PRON
fnp-3801	42	44	ifn	ifn	VERB
fnp-3801	42	45	response	response	NOUN
fnp-3801	42	46	and	and	CCONJ
fnp-3801	42	47	inflammation	inflammation	NOUN
fnp-3801	42	48	in	in	ADP
fnp-3801	42	49	the	the	DET
fnp-3801	42	50	brain	brain	NOUN
fnp-3801	43	1	[	[	X
fnp-3801	43	2	7	7	NUM
fnp-3801	43	3	,	,	PUNCT
fnp-3801	43	4	8	8	NUM
fnp-3801	43	5	]	]	PUNCT
fnp-3801	43	6	.	.	PUNCT
fnp-3801	44	1	now	now	ADV
fnp-3801	44	2	,	,	PUNCT
fnp-3801	44	3	aditi	aditi	PROPN
fnp-3801	44	4	et	et	PROPN
fnp-3801	44	5	al	al	PROPN
fnp-3801	44	6	.	.	PROPN
fnp-3801	44	7	have	have	AUX
fnp-3801	44	8	provided	provide	VERB
fnp-3801	44	9	evidence	evidence	NOUN
fnp-3801	44	10	that	that	SCONJ
fnp-3801	44	11	dna	dna	PROPN
fnp-3801	44	12	damage	damage	NOUN
fnp-3801	44	13	-	-	PUNCT
fnp-3801	44	14	dependent	dependent	ADJ
fnp-3801	44	15	signaling	signal	VERB
fnp-3801	44	16	rather	rather	ADV
fnp-3801	44	17	than	than	ADP
fnp-3801	44	18	type	type	NOUN
fnp-3801	44	19	i	i	PRON
fnp-3801	44	20	ifn	ifn	AUX
fnp-3801	44	21	signaling	signal	VERB
fnp-3801	44	22	underlies	underlie	VERB
fnp-3801	44	23	neurodegeneration	neurodegeneration	NOUN
fnp-3801	44	24	,	,	PUNCT
fnp-3801	44	25	in	in	ADP
fnp-3801	44	26	this	this	DET
fnp-3801	44	27	class	class	NOUN
fnp-3801	44	28	of	of	ADP
fnp-3801	44	29	interferonopathy	interferonopathy	NOUN
fnp-3801	44	30	.	.	PUNCT
fnp-3801	45	1	they	they	PRON
fnp-3801	45	2	generated	generate	VERB
fnp-3801	45	3	a	a	DET
fnp-3801	45	4	murine	murine	ADJ
fnp-3801	45	5	model	model	NOUN
fnp-3801	45	6	of	of	ADP
fnp-3801	45	7	neural	neural	ADJ
fnp-3801	45	8	rnaseh2b	rnaseh2b	PROPN
fnp-3801	45	9	inactivation	inactivation	NOUN
fnp-3801	45	10	(	(	PUNCT
fnp-3801	45	11	rnaseh2bnes	rnaseh2bnes	PROPN
fnp-3801	45	12	-	-	PUNCT
fnp-3801	45	13	cre	cre	NOUN
fnp-3801	45	14	)	)	PUNCT
fnp-3801	46	1	[	[	X
fnp-3801	46	2	9	9	NUM
fnp-3801	46	3	]	]	PUNCT
fnp-3801	46	4	.	.	PUNCT
fnp-3801	47	1	these	these	DET
fnp-3801	47	2	mice	mouse	NOUN
fnp-3801	47	3	showed	show	VERB
fnp-3801	47	4	smaller	small	ADJ
fnp-3801	47	5	cerebellar	cerebellar	ADJ
fnp-3801	47	6	volume	volume	NOUN
fnp-3801	47	7	and	and	CCONJ
fnp-3801	47	8	reduced	reduced	ADJ
fnp-3801	47	9	granule	granule	NOUN
fnp-3801	47	10	cell	cell	NOUN
fnp-3801	47	11	and	and	CCONJ
fnp-3801	47	12	interneuron	interneuron	NOUN
fnp-3801	47	13	number	number	NOUN
fnp-3801	47	14	.	.	PUNCT
fnp-3801	48	1	the	the	DET
fnp-3801	48	2	authors	author	NOUN
fnp-3801	48	3	found	find	VERB
fnp-3801	48	4	that	that	SCONJ
fnp-3801	48	5	reduced	reduce	VERB
fnp-3801	48	6	cerebellar	cerebellar	ADJ
fnp-3801	48	7	volume	volume	NOUN
fnp-3801	48	8	was	be	AUX
fnp-3801	48	9	explained	explain	VERB
fnp-3801	48	10	by	by	ADP
fnp-3801	48	11	the	the	DET
fnp-3801	48	12	loss	loss	NOUN
fnp-3801	48	13	of	of	ADP
fnp-3801	48	14	proliferative	proliferative	ADJ
fnp-3801	48	15	neurons	neuron	NOUN
fnp-3801	48	16	as	as	ADP
fnp-3801	48	17	a	a	DET
fnp-3801	48	18	consequence	consequence	NOUN
fnp-3801	48	19	of	of	ADP
fnp-3801	48	20	dna	dna	NOUN
fnp-3801	48	21	damage	damage	NOUN
fnp-3801	48	22	-	-	PUNCT
fnp-3801	48	23	induced	induce	VERB
fnp-3801	48	24	cell	cell	NOUN
fnp-3801	48	25	death	death	NOUN
fnp-3801	48	26	.	.	PUNCT
fnp-3801	49	1	they	they	PRON
fnp-3801	49	2	found	find	VERB
fnp-3801	49	3	increased	increase	VERB
fnp-3801	49	4	dna	dna	ADJ
fnp-3801	49	5	double	double	ADJ
fnp-3801	49	6	-	-	PUNCT
fnp-3801	49	7	strand	strand	NOUN
fnp-3801	49	8	breaks	break	NOUN
fnp-3801	49	9	in	in	ADP
fnp-3801	49	10	cells	cell	NOUN
fnp-3801	49	11	using	use	VERB
fnp-3801	49	12	the	the	DET
fnp-3801	49	13	h2a	h2a	ADJ
fnp-3801	49	14	histone	histone	NOUN
fnp-3801	49	15	family	family	NOUN
fnp-3801	49	16	member	member	NOUN
fnp-3801	49	17	x	x	INTJ
fnp-3801	49	18	(	(	PUNCT
fnp-3801	49	19	γh2ax	γh2ax	PROPN
fnp-3801	49	20	)	)	PUNCT
fnp-3801	49	21	marker	marker	NOUN
fnp-3801	49	22	.	.	PUNCT
fnp-3801	50	1	the	the	DET
fnp-3801	50	2	authors	author	NOUN
fnp-3801	50	3	used	use	VERB
fnp-3801	50	4	rna	rna	NOUN
fnp-3801	50	5	-	-	PUNCT
fnp-3801	50	6	sequencing	sequence	VERB
fnp-3801	50	7	to	to	PART
fnp-3801	50	8	compare	compare	VERB
fnp-3801	50	9	cerebellar	cerebellar	ADJ
fnp-3801	50	10	tissue	tissue	NOUN
fnp-3801	50	11	of	of	ADP
fnp-3801	50	12	rnaseh2bnes	rnaseh2bne	NOUN
fnp-3801	50	13	-	-	PUNCT
fnp-3801	50	14	cre	cre	PROPN
fnp-3801	50	15	and	and	CCONJ
fnp-3801	50	16	controls	control	NOUN
fnp-3801	50	17	.	.	PUNCT
fnp-3801	51	1	they	they	PRON
fnp-3801	51	2	found	find	VERB
fnp-3801	51	3	that	that	SCONJ
fnp-3801	51	4	genes	gene	NOUN
fnp-3801	51	5	involved	involve	VERB
fnp-3801	51	6	in	in	ADP
fnp-3801	51	7	type	type	NOUN
fnp-3801	51	8	i	i	PRON
fnp-3801	51	9	ifn	ifn	NOUN
fnp-3801	51	10	-	-	PUNCT
fnp-3801	51	11	α	α	NOUN
fnp-3801	51	12	response	response	NOUN
fnp-3801	51	13	pathway	pathway	NOUN
fnp-3801	51	14	were	be	AUX
fnp-3801	51	15	particularly	particularly	ADV
fnp-3801	51	16	enriched	enrich	VERB
fnp-3801	51	17	in	in	ADP
fnp-3801	51	18	rnaseh2bnes	rnaseh2bne	NOUN
fnp-3801	51	19	-	-	PUNCT
fnp-3801	51	20	cre	cre	PROPN
fnp-3801	51	21	cerebellar	cerebellar	PROPN
fnp-3801	51	22	cells	cell	NOUN
fnp-3801	51	23	indicating	indicate	VERB
fnp-3801	51	24	that	that	SCONJ
fnp-3801	51	25	rnaseh2	rnaseh2	NOUN
fnp-3801	51	26	deficiency	deficiency	NOUN
fnp-3801	51	27	leads	lead	VERB
fnp-3801	51	28	to	to	ADP
fnp-3801	51	29	an	an	DET
fnp-3801	51	30	increased	increase	VERB
fnp-3801	51	31	type	type	NOUN
fnp-3801	51	32	i	i	PRON
fnp-3801	51	33	ifn	ifn	VERB
fnp-3801	51	34	response	response	NOUN
fnp-3801	51	35	.	.	PUNCT
fnp-3801	52	1	consistent	consistent	ADJ
fnp-3801	52	2	with	with	ADP
fnp-3801	52	3	the	the	DET
fnp-3801	52	4	upregulation	upregulation	NOUN
fnp-3801	52	5	of	of	ADP
fnp-3801	52	6	neuroinflammatory	neuroinflammatory	ADJ
fnp-3801	52	7	genes	gene	NOUN
fnp-3801	52	8	in	in	ADP
fnp-3801	52	9	rnaseh2bnes	rnaseh2bne	NOUN
fnp-3801	52	10	-	-	PUNCT
fnp-3801	52	11	cre	cre	NOUN
fnp-3801	52	12	cerebellum	cerebellum	NOUN
fnp-3801	52	13	,	,	PUNCT
fnp-3801	52	14	they	they	PRON
fnp-3801	52	15	also	also	ADV
fnp-3801	52	16	found	find	VERB
fnp-3801	52	17	astroand	astroand	ADJ
fnp-3801	52	18	microglial	microglial	ADJ
fnp-3801	52	19	genes	gene	NOUN
fnp-3801	52	20	such	such	ADJ
fnp-3801	52	21	as	as	ADP
fnp-3801	52	22	glial	glial	ADJ
fnp-3801	52	23	fibrillary	fibrillary	ADJ
fnp-3801	52	24	acidic	acidic	ADJ
fnp-3801	52	25	protein	protein	NOUN
fnp-3801	52	26	(	(	PUNCT
fnp-3801	52	27	gfap	gfap	ADJ
fnp-3801	52	28	)	)	PUNCT
fnp-3801	52	29	and	and	CCONJ
fnp-3801	52	30	ionized	ionized	ADJ
fnp-3801	52	31	calcium	calcium	NOUN
fnp-3801	52	32	-	-	PUNCT
fnp-3801	52	33	binding	bind	VERB
fnp-3801	52	34	adaptor	adaptor	NOUN
fnp-3801	52	35	molecule	molecule	NOUN
fnp-3801	52	36	1	1	NUM
fnp-3801	52	37	(	(	PUNCT
fnp-3801	52	38	iba1	iba1	PROPN
fnp-3801	52	39	)	)	PUNCT
fnp-3801	52	40	were	be	AUX
fnp-3801	52	41	particularly	particularly	ADV
fnp-3801	52	42	upregulated	upregulate	VERB
fnp-3801	52	43	in	in	ADP
fnp-3801	52	44	rnaseh2bnes	rnaseh2bne	NOUN
fnp-3801	52	45	-	-	PUNCT
fnp-3801	52	46	cre	cre	NOUN
fnp-3801	52	47	cerebellum	cerebellum	NOUN
fnp-3801	52	48	.	.	PUNCT
fnp-3801	53	1	these	these	DET
fnp-3801	53	2	data	datum	NOUN
fnp-3801	53	3	suggest	suggest	VERB
fnp-3801	53	4	an	an	DET
fnp-3801	53	5	ongoing	ongoing	ADJ
fnp-3801	53	6	astrocytosis	astrocytosis	NOUN
fnp-3801	53	7	and	and	CCONJ
fnp-3801	53	8	microglial	microglial	ADJ
fnp-3801	53	9	activation	activation	NOUN
fnp-3801	53	10	that	that	PRON
fnp-3801	53	11	are	be	AUX
fnp-3801	53	12	hallmarks	hallmark	NOUN
fnp-3801	53	13	of	of	ADP
fnp-3801	53	14	neuroinflammation	neuroinflammation	NOUN
fnp-3801	53	15	.	.	PUNCT
fnp-3801	54	1	remarkably	remarkably	ADV
fnp-3801	54	2	,	,	PUNCT
fnp-3801	54	3	inactivation	inactivation	NOUN
fnp-3801	54	4	of	of	ADP
fnp-3801	54	5	tumor	tumor	NOUN
fnp-3801	54	6	protein	protein	NOUN
fnp-3801	54	7	p53	p53	NOUN
fnp-3801	54	8	,	,	PUNCT
fnp-3801	54	9	which	which	PRON
fnp-3801	54	10	induces	induce	VERB
fnp-3801	54	11	apoptosis	apoptosis	NOUN
fnp-3801	54	12	in	in	ADP
fnp-3801	54	13	damaged	damage	VERB
fnp-3801	54	14	cells	cell	NOUN
fnp-3801	54	15	,	,	PUNCT
fnp-3801	54	16	rescued	rescue	VERB
fnp-3801	54	17	dna	dna	NOUN
fnp-3801	54	18	damage	damage	NOUN
fnp-3801	54	19	-	-	PUNCT
fnp-3801	54	20	induced	induce	VERB
fnp-3801	54	21	cell	cell	NOUN
fnp-3801	54	22	death	death	NOUN
fnp-3801	54	23	and	and	CCONJ
fnp-3801	54	24	cerebellar	cerebellar	ADJ
fnp-3801	54	25	atrophy	atrophy	NOUN
fnp-3801	54	26	but	but	CCONJ
fnp-3801	54	27	led	lead	VERB
fnp-3801	54	28	to	to	ADP
fnp-3801	54	29	accumulation	accumulation	NOUN
fnp-3801	54	30	of	of	ADP
fnp-3801	54	31	cytoplasmic	cytoplasmic	ADJ
fnp-3801	54	32	dna	dna	PROPN
fnp-3801	54	33	damage	damage	NOUN
fnp-3801	54	34	that	that	PRON
fnp-3801	54	35	resulted	result	VERB
fnp-3801	54	36	in	in	ADP
fnp-3801	54	37	the	the	DET
fnp-3801	54	38	development	development	NOUN
fnp-3801	54	39	of	of	ADP
fnp-3801	54	40	medulloblastoma	medulloblastoma	NOUN
fnp-3801	54	41	.	.	PUNCT
fnp-3801	55	1	the	the	DET
fnp-3801	55	2	authors	author	NOUN
fnp-3801	55	3	also	also	ADV
fnp-3801	55	4	demonstrated	demonstrate	VERB
fnp-3801	55	5	that	that	SCONJ
fnp-3801	55	6	neurodegeneration	neurodegeneration	NOUN
fnp-3801	55	7	of	of	ADP
fnp-3801	55	8	rnaseh2bnes	rnaseh2bnes	PROPN
fnp-3801	55	9	-	-	PUNCT
fnp-3801	55	10	cre	cre	NOUN
fnp-3801	55	11	mice	mouse	NOUN
fnp-3801	55	12	was	be	AUX
fnp-3801	55	13	not	not	PART
fnp-3801	55	14	driven	drive	VERB
fnp-3801	55	15	by	by	ADP
fnp-3801	55	16	type	type	NOUN
fnp-3801	55	17	i	i	PRON
fnp-3801	55	18	ifn	ifn	VERB
fnp-3801	55	19	signaling	signal	VERB
fnp-3801	55	20	since	since	SCONJ
fnp-3801	55	21	the	the	DET
fnp-3801	55	22	deletion	deletion	NOUN
fnp-3801	55	23	of	of	ADP
fnp-3801	55	24	cyclic	cyclic	PROPN
fnp-3801	55	25	gmp	gmp	PROPN
fnp-3801	55	26	–	–	PUNCT
fnp-3801	55	27	amp	amp	NOUN
fnp-3801	55	28	synthase	synthase	NOUN
fnp-3801	55	29	(	(	PUNCT
fnp-3801	55	30	cgas	cgas	ADJ
fnp-3801	55	31	)	)	PUNCT
fnp-3801	55	32	,	,	PUNCT
fnp-3801	55	33	a	a	DET
fnp-3801	55	34	factor	factor	NOUN
fnp-3801	55	35	that	that	PRON
fnp-3801	55	36	is	be	AUX
fnp-3801	55	37	required	require	VERB
fnp-3801	55	38	for	for	ADP
fnp-3801	55	39	type	type	NOUN
fnp-3801	55	40	i	i	PRON
fnp-3801	55	41	ifn	ifn	VERB
fnp-3801	55	42	activation	activation	NOUN
fnp-3801	55	43	,	,	PUNCT
fnp-3801	55	44	led	lead	VERB
fnp-3801	55	45	to	to	ADP
fnp-3801	55	46	similar	similar	ADJ
fnp-3801	55	47	phenotypes	phenotype	NOUN
fnp-3801	55	48	in	in	ADP
fnp-3801	55	49	rnaseh2bnes	rnaseh2bne	NOUN
fnp-3801	55	50	-	-	PUNCT
fnp-3801	55	51	cre	cre	NOUN
fnp-3801	55	52	mice	mouse	NOUN
fnp-3801	55	53	.	.	PUNCT
fnp-3801	56	1	all	all	DET
fnp-3801	56	2	these	these	DET
fnp-3801	56	3	data	datum	NOUN
fnp-3801	56	4	together	together	ADV
fnp-3801	56	5	provide	provide	VERB
fnp-3801	56	6	new	new	ADJ
fnp-3801	56	7	levels	level	NOUN
fnp-3801	56	8	of	of	ADP
fnp-3801	56	9	understanding	understanding	NOUN
fnp-3801	56	10	about	about	ADP
fnp-3801	56	11	ags	ag	NOUN
fnp-3801	56	12	neuropathology	neuropathology	NOUN
fnp-3801	56	13	and	and	CCONJ
fnp-3801	56	14	suggest	suggest	VERB
fnp-3801	56	15	that	that	SCONJ
fnp-3801	56	16	neuroinflammation	neuroinflammation	NOUN
fnp-3801	56	17	is	be	AUX
fnp-3801	56	18	not	not	PART
fnp-3801	56	19	the	the	DET
fnp-3801	56	20	main	main	ADJ
fnp-3801	56	21	cause	cause	NOUN
fnp-3801	56	22	of	of	ADP
fnp-3801	56	23	ags	ag	NOUN
fnp-3801	56	24	phenotypes	phenotype	NOUN
fnp-3801	56	25	,	,	PUNCT
fnp-3801	56	26	but	but	CCONJ
fnp-3801	56	27	is	be	AUX
fnp-3801	56	28	a	a	DET
fnp-3801	56	29	consequence	consequence	NOUN
fnp-3801	56	30	derived	derive	VERB
fnp-3801	56	31	from	from	ADP
fnp-3801	56	32	increased	increase	VERB
fnp-3801	56	33	dna	dna	PROPN
fnp-3801	56	34	damage	damage	NOUN
fnp-3801	56	35	due	due	ADP
fnp-3801	56	36	to	to	ADP
fnp-3801	56	37	rnaseh2b	rnaseh2b	PROPN
fnp-3801	56	38	mutations	mutation	NOUN
fnp-3801	56	39	.	.	PUNCT
fnp-3801	57	1	in	in	ADP
fnp-3801	57	2	this	this	DET
fnp-3801	57	3	regard	regard	NOUN
fnp-3801	57	4	,	,	PUNCT
fnp-3801	57	5	those	those	DET
fnp-3801	57	6	individuals	individual	NOUN
fnp-3801	57	7	with	with	ADP
fnp-3801	57	8	additional	additional	ADJ
fnp-3801	57	9	mutations	mutation	NOUN
fnp-3801	57	10	in	in	ADP
fnp-3801	57	11	dna	dna	PROPN
fnp-3801	57	12	repair	repair	NOUN
fnp-3801	57	13	genes	gene	NOUN
fnp-3801	57	14	might	might	AUX
fnp-3801	57	15	be	be	AUX
fnp-3801	57	16	more	more	ADV
fnp-3801	57	17	prone	prone	ADJ
fnp-3801	57	18	to	to	PART
fnp-3801	57	19	present	present	VERB
fnp-3801	57	20	exaggerated	exaggerated	ADJ
fnp-3801	57	21	immune	immune	ADJ
fnp-3801	57	22	responses	response	NOUN
fnp-3801	57	23	as	as	ADP
fnp-3801	57	24	a	a	DET
fnp-3801	57	25	consequence	consequence	NOUN
fnp-3801	57	26	of	of	ADP
fnp-3801	57	27	increased	increase	VERB
fnp-3801	57	28	dna	dna	PROPN
fnp-3801	57	29	damage	damage	NOUN
fnp-3801	57	30	.	.	PUNCT
fnp-3801	58	1	this	this	DET
fnp-3801	58	2	discovery	discovery	NOUN
fnp-3801	58	3	constitutes	constitute	VERB
fnp-3801	58	4	a	a	DET
fnp-3801	58	5	paradigm	paradigm	NOUN
fnp-3801	58	6	-	-	PUNCT
fnp-3801	58	7	shift	shift	NOUN
fnp-3801	58	8	in	in	ADP
fnp-3801	58	9	interferonopathies	interferonopathie	NOUN
fnp-3801	58	10	and	and	CCONJ
fnp-3801	58	11	changes	change	VERB
fnp-3801	58	12	the	the	DET
fnp-3801	58	13	assumptions	assumption	NOUN
fnp-3801	58	14	about	about	ADP
fnp-3801	58	15	the	the	DET
fnp-3801	58	16	genetic	genetic	ADJ
fnp-3801	58	17	and	and	CCONJ
fnp-3801	58	18	molecular	molecular	ADJ
fnp-3801	58	19	causes	cause	NOUN
fnp-3801	58	20	of	of	ADP
fnp-3801	58	21	ags	ag	NOUN
fnp-3801	58	22	.	.	PUNCT
fnp-3801	58	23	reconsidering	reconsider	VERB
fnp-3801	58	24	the	the	DET
fnp-3801	58	25	leading	lead	VERB
fnp-3801	58	26	cause	cause	NOUN
fnp-3801	58	27	of	of	ADP
fnp-3801	58	28	ags	ag	NOUN
fnp-3801	58	29	neuropathology	neuropathology	NOUN
fnp-3801	58	30	can	can	AUX
fnp-3801	58	31	help	help	VERB
fnp-3801	58	32	not	not	PART
fnp-3801	58	33	only	only	ADV
fnp-3801	58	34	to	to	PART
fnp-3801	58	35	disentangle	disentangle	VERB
fnp-3801	58	36	the	the	DET
fnp-3801	58	37	complex	complex	ADJ
fnp-3801	58	38	neuropathology	neuropathology	NOUN
fnp-3801	58	39	of	of	ADP
fnp-3801	58	40	this	this	DET
fnp-3801	58	41	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	58	42	disorder	disorder	NOUN
fnp-3801	58	43	,	,	PUNCT
fnp-3801	58	44	but	but	CCONJ
fnp-3801	58	45	also	also	ADV
fnp-3801	58	46	to	to	PART
fnp-3801	58	47	specifically	specifically	ADV
fnp-3801	58	48	design	design	VERB
fnp-3801	58	49	strategies	strategy	NOUN
fnp-3801	58	50	that	that	PRON
fnp-3801	58	51	would	would	AUX
fnp-3801	58	52	help	help	VERB
fnp-3801	58	53	to	to	PART
fnp-3801	58	54	ameliorate	ameliorate	VERB
fnp-3801	58	55	the	the	DET
fnp-3801	58	56	symptoms	symptom	NOUN
fnp-3801	58	57	associated	associate	VERB
fnp-3801	58	58	with	with	ADP
fnp-3801	58	59	dna	dna	PROPN
fnp-3801	58	60	damage	damage	NOUN
fnp-3801	58	61	-	-	PUNCT
fnp-3801	58	62	driven	drive	VERB
fnp-3801	58	63	neuroinflammatory	neuroinflammatory	ADJ
fnp-3801	58	64	response	response	NOUN
fnp-3801	58	65	in	in	ADP
fnp-3801	58	66	ags	ag	NOUN
fnp-3801	58	67	.	.	PUNCT
fnp-3801	59	1	understanding	understand	VERB
fnp-3801	59	2	cortical	cortical	ADJ
fnp-3801	59	3	neurodevelopment	neurodevelopment	NOUN
fnp-3801	59	4	from	from	ADP
fnp-3801	59	5	evolution	evolution	NOUN
fnp-3801	59	6	genetic	genetic	ADJ
fnp-3801	59	7	disease	disease	NOUN
fnp-3801	59	8	is	be	AUX
fnp-3801	59	9	a	a	DET
fnp-3801	59	10	necessary	necessary	ADJ
fnp-3801	59	11	product	product	NOUN
fnp-3801	59	12	of	of	ADP
fnp-3801	59	13	evolution	evolution	NOUN
fnp-3801	59	14	.	.	PUNCT
fnp-3801	60	1	in	in	ADP
fnp-3801	60	2	fact	fact	NOUN
fnp-3801	60	3	,	,	PUNCT
fnp-3801	60	4	evolutionary	evolutionary	ADJ
fnp-3801	60	5	pressures	pressure	NOUN
fnp-3801	60	6	have	have	AUX
fnp-3801	60	7	established	establish	VERB
fnp-3801	60	8	the	the	DET
fnp-3801	60	9	risk	risk	NOUN
fnp-3801	60	10	for	for	ADP
fnp-3801	60	11	many	many	ADJ
fnp-3801	60	12	neuropsychiatric	neuropsychiatric	ADJ
fnp-3801	60	13	or	or	CCONJ
fnp-3801	60	14	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	60	15	diseases	disease	NOUN
fnp-3801	60	16	.	.	PUNCT
fnp-3801	61	1	nearly	nearly	ADV
fnp-3801	61	2	all	all	PRON
fnp-3801	61	3	genetic	genetic	ADJ
fnp-3801	61	4	variants	variant	NOUN
fnp-3801	61	5	that	that	PRON
fnp-3801	61	6	influence	influence	NOUN
fnp-3801	61	7	disease	disease	NOUN
fnp-3801	61	8	risk	risk	NOUN
fnp-3801	61	9	have	have	VERB
fnp-3801	61	10	human	human	ADJ
fnp-3801	61	11	-	-	PUNCT
fnp-3801	61	12	specific	specific	ADJ
fnp-3801	61	13	origins	origin	NOUN
fnp-3801	61	14	.	.	PUNCT
fnp-3801	62	1	fundamental	fundamental	ADJ
fnp-3801	62	2	biological	biological	ADJ
fnp-3801	62	3	systems	system	NOUN
fnp-3801	62	4	,	,	PUNCT
fnp-3801	62	5	such	such	ADJ
fnp-3801	62	6	as	as	ADP
fnp-3801	62	7	dna	dna	PROPN
fnp-3801	62	8	replication	replication	NOUN
fnp-3801	62	9	,	,	PUNCT
fnp-3801	62	10	transcription	transcription	NOUN
fnp-3801	62	11	and	and	CCONJ
fnp-3801	62	12	translation	translation	NOUN
fnp-3801	62	13	,	,	PUNCT
fnp-3801	62	14	evolved	evolve	VERB
fnp-3801	62	15	very	very	ADV
fnp-3801	62	16	early	early	ADV
fnp-3801	62	17	in	in	ADP
fnp-3801	62	18	the	the	DET
fnp-3801	62	19	history	history	NOUN
fnp-3801	62	20	of	of	ADP
fnp-3801	62	21	life	life	NOUN
fnp-3801	62	22	,	,	PUNCT
fnp-3801	62	23	to	to	PART
fnp-3801	62	24	give	give	VERB
fnp-3801	62	25	rise	rise	NOUN
fnp-3801	62	26	to	to	ADP
fnp-3801	62	27	cellular	cellular	ADJ
fnp-3801	62	28	life	life	NOUN
fnp-3801	62	29	,	,	PUNCT
fnp-3801	62	30	but	but	CCONJ
fnp-3801	62	31	also	also	ADV
fnp-3801	62	32	created	create	VERB
fnp-3801	62	33	the	the	DET
fnp-3801	62	34	potential	potential	NOUN
fnp-3801	62	35	for	for	ADP
fnp-3801	62	36	disease	disease	NOUN
fnp-3801	62	37	.	.	PUNCT
fnp-3801	63	1	among	among	ADP
fnp-3801	63	2	those	those	PRON
fnp-3801	63	3	,	,	PUNCT
fnp-3801	63	4	alternative	alternative	ADJ
fnp-3801	63	5	splicing	splicing	NOUN
fnp-3801	63	6	is	be	AUX
fnp-3801	63	7	a	a	DET
fnp-3801	63	8	form	form	NOUN
fnp-3801	63	9	of	of	ADP
fnp-3801	63	10	genetic	genetic	ADJ
fnp-3801	63	11	regulation	regulation	NOUN
fnp-3801	63	12	that	that	PRON
fnp-3801	63	13	enables	enable	VERB
fnp-3801	63	14	the	the	DET
fnp-3801	63	15	production	production	NOUN
fnp-3801	63	16	of	of	ADP
fnp-3801	63	17	multiple	multiple	ADJ
fnp-3801	63	18	proteins	protein	NOUN
fnp-3801	63	19	from	from	ADP
fnp-3801	63	20	a	a	DET
fnp-3801	63	21	single	single	ADJ
fnp-3801	63	22	gene	gene	NOUN
fnp-3801	63	23	.	.	PUNCT
fnp-3801	64	1	differences	difference	NOUN
fnp-3801	64	2	in	in	ADP
fnp-3801	64	3	splicing	splicing	NOUN
fnp-3801	64	4	arose	arise	VERB
fnp-3801	64	5	rapidly	rapidly	ADV
fnp-3801	64	6	during	during	ADP
fnp-3801	64	7	a	a	DET
fnp-3801	64	8	recent	recent	ADJ
fnp-3801	64	9	evolutionary	evolutionary	ADJ
fnp-3801	64	10	transition	transition	NOUN
fnp-3801	64	11	and	and	CCONJ
fnp-3801	64	12	appear	appear	VERB
fnp-3801	64	13	to	to	PART
fnp-3801	64	14	contribute	contribute	VERB
fnp-3801	64	15	to	to	ADP
fnp-3801	64	16	adaptation	adaptation	NOUN
fnp-3801	64	17	but	but	CCONJ
fnp-3801	64	18	also	also	ADV
fnp-3801	64	19	to	to	ADP
fnp-3801	64	20	brain	brain	NOUN
fnp-3801	64	21	disorder	disorder	NOUN
fnp-3801	64	22	.	.	PUNCT
fnp-3801	65	1	it	it	PRON
fnp-3801	65	2	is	be	AUX
fnp-3801	65	3	known	know	VERB
fnp-3801	65	4	that	that	SCONJ
fnp-3801	65	5	the	the	DET
fnp-3801	65	6	transcriptional	transcriptional	ADJ
fnp-3801	65	7	machinery	machinery	NOUN
fnp-3801	65	8	is	be	AUX
fnp-3801	65	9	often	often	ADV
fnp-3801	65	10	mutated	mutate	VERB
fnp-3801	65	11	in	in	ADP
fnp-3801	65	12	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	65	13	disorders	disorder	NOUN
fnp-3801	65	14	[	[	X
fnp-3801	65	15	10	10	NUM
fnp-3801	65	16	]	]	PUNCT
fnp-3801	65	17	.	.	PUNCT
fnp-3801	66	1	the	the	DET
fnp-3801	66	2	brain	brain	NOUN
fnp-3801	66	3	displays	display	VERB
fnp-3801	66	4	the	the	DET
fnp-3801	66	5	most	most	ADV
fnp-3801	66	6	complex	complex	ADJ
fnp-3801	66	7	pattern	pattern	NOUN
fnp-3801	66	8	of	of	ADP
fnp-3801	66	9	alternative	alternative	ADJ
fnp-3801	66	10	splicing	splicing	NOUN
fnp-3801	66	11	of	of	ADP
fnp-3801	66	12	the	the	DET
fnp-3801	66	13	body	body	NOUN
fnp-3801	66	14	[	[	X
fnp-3801	66	15	10	10	NUM
fnp-3801	66	16	]	]	PUNCT
fnp-3801	66	17	,	,	PUNCT
fnp-3801	66	18	with	with	ADP
fnp-3801	66	19	neuron	neuron	NOUN
fnp-3801	66	20	-	-	PUNCT
fnp-3801	66	21	specific	specific	ADJ
fnp-3801	66	22	alternative	alternative	ADJ
fnp-3801	66	23	exons	exon	NOUN
fnp-3801	66	24	such	such	ADJ
fnp-3801	66	25	as	as	ADP
fnp-3801	66	26	dna	dna	NOUN
fnp-3801	66	27	-	-	PUNCT
fnp-3801	66	28	binding	bind	VERB
fnp-3801	66	29	proteins	protein	NOUN
fnp-3801	66	30	and	and	CCONJ
fnp-3801	66	31	histone	histone	NOUN
fnp-3801	66	32	modifying	modify	VERB
fnp-3801	66	33	enzymes	enzyme	NOUN
fnp-3801	66	34	that	that	PRON
fnp-3801	66	35	regulate	regulate	VERB
fnp-3801	66	36	evolutionarily	evolutionarily	ADV
fnp-3801	66	37	conserved	conserve	VERB
fnp-3801	66	38	transcription	transcription	NOUN
fnp-3801	66	39	.	.	PUNCT
fnp-3801	67	1	given	give	VERB
fnp-3801	67	2	that	that	DET
fnp-3801	67	3	alternative	alternative	ADJ
fnp-3801	67	4	splicing	splicing	NOUN
fnp-3801	67	5	is	be	AUX
fnp-3801	67	6	necessary	necessary	ADJ
fnp-3801	67	7	for	for	ADP
fnp-3801	67	8	the	the	DET
fnp-3801	67	9	proper	proper	ADJ
fnp-3801	67	10	cortical	cortical	ADJ
fnp-3801	67	11	development	development	NOUN
fnp-3801	67	12	[	[	X
fnp-3801	67	13	11	11	NUM
fnp-3801	67	14	,	,	PUNCT
fnp-3801	67	15	12	12	NUM
fnp-3801	67	16	]	]	PUNCT
fnp-3801	67	17	,	,	PUNCT
fnp-3801	67	18	a	a	DET
fnp-3801	67	19	better	well	ADJ
fnp-3801	67	20	understanding	understanding	NOUN
fnp-3801	67	21	of	of	ADP
fnp-3801	67	22	how	how	SCONJ
fnp-3801	67	23	mutations	mutation	NOUN
fnp-3801	67	24	in	in	ADP
fnp-3801	67	25	genes	gene	NOUN
fnp-3801	67	26	associated	associate	VERB
fnp-3801	67	27	with	with	ADP
fnp-3801	67	28	alternative	alternative	ADJ
fnp-3801	67	29	splicing	splicing	NOUN
fnp-3801	67	30	would	would	AUX
fnp-3801	67	31	help	help	VERB
fnp-3801	67	32	to	to	PART
fnp-3801	67	33	unravel	unravel	VERB
fnp-3801	67	34	the	the	DET
fnp-3801	67	35	enormous	enormous	ADJ
fnp-3801	67	36	complexity	complexity	NOUN
fnp-3801	67	37	of	of	ADP
fnp-3801	67	38	several	several	ADJ
fnp-3801	67	39	ndds	ndd	NOUN
fnp-3801	67	40	.	.	PUNCT
fnp-3801	68	1	one	one	NUM
fnp-3801	68	2	interesting	interesting	ADJ
fnp-3801	68	3	example	example	NOUN
fnp-3801	68	4	is	be	AUX
fnp-3801	68	5	the	the	DET
fnp-3801	68	6	neuro	neuro	NOUN
fnp-3801	68	7	-	-	PUNCT
fnp-3801	68	8	oncological	oncological	ADJ
fnp-3801	68	9	ventral	ventral	ADJ
fnp-3801	68	10	antigen	antigen	NOUN
fnp-3801	68	11	1	1	NUM
fnp-3801	68	12	(	(	PUNCT
fnp-3801	68	13	nova1	nova1	NOUN
fnp-3801	68	14	)	)	PUNCT
fnp-3801	68	15	,	,	PUNCT
fnp-3801	68	16	which	which	PRON
fnp-3801	68	17	encodes	encode	VERB
fnp-3801	68	18	a	a	DET
fnp-3801	68	19	rna	rna	NOUN
fnp-3801	68	20	-	-	PUNCT
fnp-3801	68	21	binding	bind	VERB
fnp-3801	68	22	protein	protein	NOUN
fnp-3801	68	23	that	that	PRON
fnp-3801	68	24	acts	act	VERB
fnp-3801	68	25	as	as	ADP
fnp-3801	68	26	a	a	DET
fnp-3801	68	27	brain	brain	NOUN
fnp-3801	68	28	-	-	PUNCT
fnp-3801	68	29	specific	specific	ADJ
fnp-3801	68	30	splicing	splicing	NOUN
fnp-3801	68	31	factor	factor	NOUN
fnp-3801	68	32	.	.	PUNCT
fnp-3801	69	1	it	it	PRON
fnp-3801	69	2	regulates	regulate	VERB
fnp-3801	69	3	neuronal	neuronal	ADJ
fnp-3801	69	4	alternative	alternative	ADJ
fnp-3801	69	5	splicing	splicing	NOUN
fnp-3801	69	6	of	of	ADP
fnp-3801	69	7	genes	gene	NOUN
fnp-3801	69	8	responsible	responsible	ADJ
fnp-3801	69	9	for	for	ADP
fnp-3801	69	10	synapse	synapse	ADJ
fnp-3801	69	11	formation	formation	NOUN
fnp-3801	69	12	in	in	ADP
fnp-3801	69	13	the	the	DET
fnp-3801	69	14	developing	develop	VERB
fnp-3801	69	15	nervous	nervous	ADJ
fnp-3801	69	16	system	system	NOUN
fnp-3801	69	17	[	[	X
fnp-3801	69	18	13	13	NUM
fnp-3801	69	19	]	]	PUNCT
fnp-3801	69	20	.	.	PUNCT
fnp-3801	70	1	increasing	increase	VERB
fnp-3801	70	2	evidence	evidence	NOUN
fnp-3801	70	3	has	have	AUX
fnp-3801	70	4	implicated	implicate	VERB
fnp-3801	70	5	nova1	nova1	NOUN
fnp-3801	70	6	in	in	ADP
fnp-3801	70	7	numerous	numerous	ADJ
fnp-3801	70	8	pathological	pathological	ADJ
fnp-3801	70	9	processes	process	NOUN
fnp-3801	70	10	and	and	CCONJ
fnp-3801	70	11	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	70	12	disorders	disorder	NOUN
fnp-3801	70	13	[	[	X
fnp-3801	70	14	14	14	NUM
fnp-3801	70	15	,	,	PUNCT
fnp-3801	70	16	15	15	NUM
fnp-3801	70	17	]	]	PUNCT
fnp-3801	70	18	.	.	PUNCT
fnp-3801	71	1	mutations	mutation	NOUN
fnp-3801	71	2	in	in	ADP
fnp-3801	71	3	nova1	nova1	NOUN
fnp-3801	71	4	have	have	AUX
fnp-3801	71	5	been	be	AUX
fnp-3801	71	6	associated	associate	VERB
fnp-3801	71	7	with	with	ADP
fnp-3801	71	8	impairment	impairment	NOUN
fnp-3801	71	9	in	in	ADP
fnp-3801	71	10	the	the	DET
fnp-3801	71	11	development	development	NOUN
fnp-3801	71	12	of	of	ADP
fnp-3801	71	13	the	the	DET
fnp-3801	71	14	motor	motor	NOUN
fnp-3801	71	15	system	system	NOUN
fnp-3801	71	16	[	[	X
fnp-3801	71	17	16	16	NUM
fnp-3801	71	18	]	]	PUNCT
fnp-3801	71	19	and	and	CCONJ
fnp-3801	71	20	severe	severe	ADJ
fnp-3801	71	21	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	71	22	delays	delay	NOUN
fnp-3801	72	1	[	[	X
fnp-3801	72	2	17	17	NUM
fnp-3801	72	3	]	]	PUNCT
fnp-3801	72	4	.	.	PUNCT
fnp-3801	73	1	last	last	ADJ
fnp-3801	73	2	year	year	NOUN
fnp-3801	73	3	,	,	PUNCT
fnp-3801	73	4	a	a	DET
fnp-3801	73	5	comprehensive	comprehensive	ADJ
fnp-3801	73	6	analysis	analysis	NOUN
fnp-3801	73	7	of	of	ADP
fnp-3801	73	8	genetic	genetic	ADJ
fnp-3801	73	9	variation	variation	NOUN
fnp-3801	73	10	between	between	ADP
fnp-3801	73	11	modern	modern	ADJ
fnp-3801	73	12	humans	human	NOUN
fnp-3801	73	13	and	and	CCONJ
fnp-3801	73	14	neanderthals	neanderthal	NOUN
fnp-3801	73	15	performed	perform	VERB
fnp-3801	73	16	by	by	ADP
fnp-3801	73	17	trujillo	trujillo	PROPN
fnp-3801	73	18	et	et	PROPN
fnp-3801	73	19	al	al	PROPN
fnp-3801	73	20	.	.	PROPN
fnp-3801	73	21	detected	detect	VERB
fnp-3801	73	22	a	a	DET
fnp-3801	73	23	specific	specific	ADJ
fnp-3801	73	24	nova1	nova1	NOUN
fnp-3801	73	25	genetic	genetic	ADJ
fnp-3801	73	26	variation	variation	NOUN
fnp-3801	73	27	[	[	X
fnp-3801	73	28	18	18	NUM
fnp-3801	73	29	]	]	PUNCT
fnp-3801	73	30	.	.	PUNCT
fnp-3801	74	1	even	even	ADV
fnp-3801	74	2	though	though	SCONJ
fnp-3801	74	3	the	the	DET
fnp-3801	74	4	genomes	genome	NOUN
fnp-3801	74	5	of	of	ADP
fnp-3801	74	6	humans	human	NOUN
fnp-3801	74	7	and	and	CCONJ
fnp-3801	74	8	neanderthals	neanderthal	NOUN
fnp-3801	74	9	are	be	AUX
fnp-3801	74	10	very	very	ADV
fnp-3801	74	11	similar	similar	ADJ
fnp-3801	74	12	,	,	PUNCT
fnp-3801	74	13	this	this	DET
fnp-3801	74	14	archaic	archaic	ADJ
fnp-3801	74	15	nova1	nova1	NOUN
fnp-3801	74	16	version	version	NOUN
fnp-3801	74	17	could	could	AUX
fnp-3801	74	18	help	help	VERB
fnp-3801	74	19	to	to	PART
fnp-3801	74	20	explain	explain	VERB
fnp-3801	74	21	how	how	SCONJ
fnp-3801	75	1	nova1	nova1	NOUN
fnp-3801	76	1	variants	variant	NOUN
fnp-3801	76	2	can	can	AUX
fnp-3801	76	3	differentially	differentially	ADV
fnp-3801	76	4	regulate	regulate	VERB
fnp-3801	76	5	alternative	alternative	ADJ
fnp-3801	76	6	splicing	splicing	NOUN
fnp-3801	76	7	during	during	ADP
fnp-3801	76	8	human	human	ADJ
fnp-3801	76	9	brain	brain	NOUN
fnp-3801	76	10	development	development	NOUN
fnp-3801	76	11	.	.	PUNCT
fnp-3801	77	1	to	to	PART
fnp-3801	77	2	study	study	VERB
fnp-3801	77	3	the	the	DET
fnp-3801	77	4	functional	functional	ADJ
fnp-3801	77	5	relevance	relevance	NOUN
fnp-3801	77	6	of	of	ADP
fnp-3801	77	7	nova1	nova1	NOUN
fnp-3801	77	8	mutations	mutation	NOUN
fnp-3801	77	9	,	,	PUNCT
fnp-3801	77	10	authors	author	NOUN
fnp-3801	77	11	used	use	VERB
fnp-3801	77	12	crispr	crispr	ADJ
fnp-3801	77	13	-	-	PUNCT
fnp-3801	77	14	cas9	cas9	NOUN
fnp-3801	77	15	genome	genome	NOUN
fnp-3801	77	16	-	-	PUNCT
fnp-3801	77	17	editing	edit	VERB
fnp-3801	77	18	technology	technology	NOUN
fnp-3801	77	19	to	to	PART
fnp-3801	77	20	introduce	introduce	VERB
fnp-3801	77	21	the	the	DET
fnp-3801	77	22	archaic	archaic	ADJ
fnp-3801	77	23	variant	variant	NOUN
fnp-3801	77	24	into	into	ADP
fnp-3801	77	25	the	the	DET
fnp-3801	77	26	genome	genome	NOUN
fnp-3801	77	27	of	of	ADP
fnp-3801	77	28	human	human	ADJ
fnp-3801	77	29	induced	induced	ADJ
fnp-3801	77	30	pluripotent	pluripotent	ADJ
fnp-3801	77	31	stem	stem	NOUN
fnp-3801	77	32	cells	cell	NOUN
fnp-3801	77	33	(	(	PUNCT
fnp-3801	77	34	hipscs	hipsc	NOUN
fnp-3801	77	35	)	)	PUNCT
fnp-3801	77	36	.	.	PUNCT
fnp-3801	78	1	hipscs	hipsc	NOUN
fnp-3801	78	2	carrying	carry	VERB
fnp-3801	78	3	the	the	DET
fnp-3801	78	4	archaic	archaic	ADJ
fnp-3801	78	5	mutation	mutation	NOUN
fnp-3801	78	6	(	(	PUNCT
fnp-3801	78	7	nova1ar	nova1ar	PROPN
fnp-3801	78	8	/	/	SYM
fnp-3801	78	9	ar	ar	NOUN
fnp-3801	78	10	)	)	PUNCT
fnp-3801	78	11	and	and	CCONJ
fnp-3801	78	12	control	control	PROPN
fnp-3801	78	13	hipscs	hipsc	NOUN
fnp-3801	78	14	(	(	PUNCT
fnp-3801	78	15	nova1hu	nova1hu	PROPN
fnp-3801	78	16	/	/	SYM
fnp-3801	78	17	hu	hu	PROPN
fnp-3801	78	18	)	)	PUNCT
fnp-3801	78	19	were	be	AUX
fnp-3801	78	20	used	use	VERB
fnp-3801	78	21	to	to	PART
fnp-3801	78	22	generate	generate	VERB
fnp-3801	78	23	cortical	cortical	ADJ
fnp-3801	78	24	organoids	organoid	NOUN
fnp-3801	78	25	to	to	PART
fnp-3801	78	26	investigate	investigate	VERB
fnp-3801	78	27	the	the	DET
fnp-3801	78	28	impact	impact	NOUN
fnp-3801	78	29	of	of	ADP
fnp-3801	78	30	the	the	DET
fnp-3801	78	31	nova1ar	nova1ar	PROPN
fnp-3801	78	32	/	/	SYM
fnp-3801	78	33	ar	ar	NOUN
fnp-3801	78	34	variant	variant	NOUN
fnp-3801	78	35	on	on	ADP
fnp-3801	78	36	the	the	DET
fnp-3801	78	37	human	human	ADJ
fnp-3801	78	38	brain	brain	NOUN
fnp-3801	78	39	.	.	PUNCT
fnp-3801	79	1	trujillo	trujillo	PROPN
fnp-3801	79	2	and	and	CCONJ
fnp-3801	79	3	colleagues	colleague	NOUN
fnp-3801	79	4	found	find	VERB
fnp-3801	79	5	that	that	SCONJ
fnp-3801	79	6	nova1ar	nova1ar	PROPN
fnp-3801	79	7	/	/	SYM
fnp-3801	79	8	ar	ar	NOUN
fnp-3801	79	9	cortical	cortical	ADJ
fnp-3801	79	10	organoids	organoid	NOUN
fnp-3801	79	11	were	be	AUX
fnp-3801	79	12	smaller	small	ADJ
fnp-3801	79	13	than	than	ADP
fnp-3801	79	14	nova1hu	nova1hu	PROPN
fnp-3801	79	15	/	/	SYM
fnp-3801	79	16	hu	hu	PROPN
fnp-3801	79	17	,	,	PUNCT
fnp-3801	79	18	a	a	DET
fnp-3801	79	19	phenotype	phenotype	NOUN
fnp-3801	79	20	that	that	PRON
fnp-3801	79	21	was	be	AUX
fnp-3801	79	22	explained	explain	VERB
fnp-3801	79	23	by	by	ADP
fnp-3801	79	24	a	a	DET
fnp-3801	79	25	reduced	reduce	VERB
fnp-3801	79	26	number	number	NOUN
fnp-3801	79	27	of	of	ADP
fnp-3801	79	28	rosettes	rosette	NOUN
fnp-3801	79	29	and	and	CCONJ
fnp-3801	79	30	a	a	DET
fnp-3801	79	31	higher	high	ADJ
fnp-3801	79	32	number	number	NOUN
fnp-3801	79	33	of	of	ADP
fnp-3801	79	34	apoptotic	apoptotic	ADJ
fnp-3801	79	35	cells	cell	NOUN
fnp-3801	79	36	in	in	ADP
fnp-3801	79	37	nova1ar	nova1ar	PROPN
fnp-3801	79	38	/	/	SYM
fnp-3801	79	39	ar	ar	NOUN
fnp-3801	79	40	along	along	ADP
fnp-3801	79	41	with	with	ADP
fnp-3801	79	42	a	a	DET
fnp-3801	79	43	reduced	reduce	VERB
fnp-3801	79	44	number	number	NOUN
fnp-3801	79	45	of	of	ADP
fnp-3801	79	46	proliferating	proliferate	VERB
fnp-3801	79	47	cells	cell	NOUN
fnp-3801	79	48	compared	compare	VERB
fnp-3801	79	49	to	to	ADP
fnp-3801	79	50	the	the	DET
fnp-3801	79	51	nova1hu	nova1hu	PROPN
fnp-3801	79	52	/	/	SYM
fnp-3801	79	53	hu	hu	PROPN
fnp-3801	79	54	organoids	organoid	NOUN
fnp-3801	79	55	.	.	PUNCT
fnp-3801	80	1	the	the	DET
fnp-3801	80	2	authors	author	NOUN
fnp-3801	80	3	also	also	ADV
fnp-3801	80	4	found	find	VERB
fnp-3801	80	5	several	several	ADJ
fnp-3801	80	6	genes	gene	NOUN
fnp-3801	80	7	differentially	differentially	ADV
fnp-3801	80	8	expressed	express	VERB
fnp-3801	80	9	in	in	ADP
fnp-3801	80	10	nova1ar	nova1ar	PROPN
fnp-3801	80	11	/	/	SYM
fnp-3801	80	12	ar	ar	NOUN
fnp-3801	80	13	such	such	ADJ
fnp-3801	80	14	as	as	ADP
fnp-3801	80	15	rps4y1	rps4y1	NOUN
fnp-3801	80	16	and	and	CCONJ
fnp-3801	80	17	nnat	nnat	NOUN
fnp-3801	80	18	,	,	PUNCT
fnp-3801	80	19	which	which	PRON
fnp-3801	80	20	are	be	AUX
fnp-3801	80	21	involved	involve	VERB
fnp-3801	80	22	in	in	ADP
fnp-3801	80	23	neuronal	neuronal	ADJ
fnp-3801	80	24	differentiation	differentiation	NOUN
fnp-3801	80	25	,	,	PUNCT
fnp-3801	80	26	tdgf1	tdgf1	NOUN
fnp-3801	80	27	,	,	PUNCT
fnp-3801	80	28	involved	involve	VERB
fnp-3801	80	29	in	in	ADP
fnp-3801	80	30	cell	cell	NOUN
fnp-3801	80	31	migration	migration	NOUN
fnp-3801	80	32	and	and	CCONJ
fnp-3801	80	33	proliferation	proliferation	NOUN
fnp-3801	80	34	,	,	PUNCT
fnp-3801	80	35	or	or	CCONJ
fnp-3801	80	36	pax6	pax6	PROPN
fnp-3801	80	37	and	and	CCONJ
fnp-3801	80	38	lhx5	lhx5	PROPN
fnp-3801	80	39	,	,	PUNCT
fnp-3801	80	40	transcription	transcription	NOUN
fnp-3801	80	41	factors	factor	NOUN
fnp-3801	80	42	associated	associate	VERB
fnp-3801	80	43	with	with	ADP
fnp-3801	80	44	cell	cell	NOUN
fnp-3801	80	45	differentiation	differentiation	NOUN
fnp-3801	80	46	during	during	ADP
fnp-3801	80	47	brain	brain	NOUN
fnp-3801	80	48	development	development	NOUN
fnp-3801	80	49	.	.	PUNCT
fnp-3801	81	1	trujillo	trujillo	PROPN
fnp-3801	81	2	and	and	CCONJ
fnp-3801	81	3	colleagues	colleague	NOUN
fnp-3801	81	4	investigated	investigate	VERB
fnp-3801	81	5	the	the	DET
fnp-3801	81	6	gene	gene	NOUN
fnp-3801	81	7	-	-	PUNCT
fnp-3801	81	8	splicing	splicing	NOUN
fnp-3801	81	9	variants	variant	NOUN
fnp-3801	81	10	of	of	ADP
fnp-3801	81	11	nova1ar	nova1ar	PROPN
fnp-3801	81	12	/	/	SYM
fnp-3801	81	13	ar	ar	PROPN
fnp-3801	81	14	and	and	CCONJ
fnp-3801	81	15	nova1hu	nova1hu	PROPN
fnp-3801	81	16	/	/	SYM
fnp-3801	81	17	hu	hu	PROPN
fnp-3801	81	18	using	use	VERB
fnp-3801	81	19	single	single	ADJ
fnp-3801	81	20	-	-	PUNCT
fnp-3801	81	21	nuclei	nuclei	NOUN
fnp-3801	81	22	rna	rna	NOUN
fnp-3801	81	23	-	-	PUNCT
fnp-3801	81	24	seq	seq	NOUN
fnp-3801	81	25	and	and	CCONJ
fnp-3801	81	26	identified	identify	VERB
fnp-3801	81	27	differences	difference	NOUN
fnp-3801	81	28	in	in	ADP
fnp-3801	81	29	alternative	alternative	ADJ
fnp-3801	81	30	splicing	splicing	NOUN
fnp-3801	81	31	events	event	NOUN
fnp-3801	81	32	affecting	affect	VERB
fnp-3801	81	33	122	122	NUM
fnp-3801	81	34	genes	gene	NOUN
fnp-3801	81	35	.	.	PUNCT
fnp-3801	82	1	remarkably	remarkably	ADV
fnp-3801	82	2	,	,	PUNCT
fnp-3801	82	3	most	most	ADJ
fnp-3801	82	4	of	of	ADP
fnp-3801	82	5	the	the	DET
fnp-3801	82	6	differentially	differentially	ADV
fnp-3801	82	7	spliced	splice	VERB
fnp-3801	82	8	genes	gene	NOUN
fnp-3801	82	9	in	in	ADP
fnp-3801	82	10	nova1ar	nova1ar	PROPN
fnp-3801	82	11	/	/	SYM
fnp-3801	82	12	ar	ar	NOUN
fnp-3801	82	13	organoids	organoid	NOUN
fnp-3801	82	14	are	be	AUX
fnp-3801	82	15	involved	involve	VERB
fnp-3801	82	16	in	in	ADP
fnp-3801	82	17	synaptogenesis	synaptogenesis	NOUN
fnp-3801	82	18	and	and	CCONJ
fnp-3801	82	19	neuronal	neuronal	ADJ
fnp-3801	82	20	connectivity	connectivity	NOUN
fnp-3801	82	21	.	.	PUNCT
fnp-3801	83	1	more	more	ADJ
fnp-3801	83	2	in	in	ADP
fnp-3801	83	3	detail	detail	NOUN
fnp-3801	83	4	,	,	PUNCT
fnp-3801	83	5	nova1ar	nova1ar	PROPN
fnp-3801	83	6	/	/	SYM
fnp-3801	83	7	ar	ar	NOUN
fnp-3801	83	8	cells	cell	NOUN
fnp-3801	83	9	had	have	VERB
fnp-3801	83	10	reduced	reduce	VERB
fnp-3801	83	11	levels	level	NOUN
fnp-3801	83	12	of	of	ADP
fnp-3801	83	13	preand	preand	NOUN
fnp-3801	83	14	postsynaptic	postsynaptic	ADJ
fnp-3801	83	15	markers	marker	NOUN
fnp-3801	83	16	such	such	ADJ
fnp-3801	83	17	as	as	ADP
fnp-3801	83	18	psd95	psd95	NOUN
fnp-3801	83	19	and	and	CCONJ
fnp-3801	83	20	nmda	nmda	ADJ
fnp-3801	83	21	,	,	PUNCT
fnp-3801	83	22	closely	closely	ADV
fnp-3801	83	23	related	relate	VERB
fnp-3801	83	24	with	with	ADP
fnp-3801	83	25	activity	activity	NOUN
fnp-3801	83	26	-	-	PUNCT
fnp-3801	83	27	dependent	dependent	ADJ
fnp-3801	83	28	plasticity	plasticity	NOUN
fnp-3801	83	29	.	.	PUNCT
fnp-3801	84	1	finally	finally	ADV
fnp-3801	84	2	,	,	PUNCT
fnp-3801	84	3	they	they	PRON
fnp-3801	84	4	evaluated	evaluate	VERB
fnp-3801	84	5	how	how	SCONJ
fnp-3801	84	6	these	these	DET
fnp-3801	84	7	synaptic	synaptic	ADJ
fnp-3801	84	8	changes	change	NOUN
fnp-3801	84	9	could	could	AUX
fnp-3801	84	10	impact	impact	VERB
fnp-3801	84	11	neuronal	neuronal	ADJ
fnp-3801	84	12	network	network	NOUN
fnp-3801	84	13	activity	activity	NOUN
fnp-3801	84	14	using	use	VERB
fnp-3801	84	15	a	a	DET
fnp-3801	84	16	multielectrode	multielectrode	NOUN
fnp-3801	84	17	array	array	NOUN
fnp-3801	84	18	that	that	SCONJ
fnp-3801	84	19	measures	measure	VERB
fnp-3801	84	20	several	several	ADJ
fnp-3801	84	21	electrophysiological	electrophysiological	ADJ
fnp-3801	84	22	properties	property	NOUN
fnp-3801	84	23	.	.	PUNCT
fnp-3801	85	1	nova1ar	nova1ar	PROPN
fnp-3801	85	2	/	/	SYM
fnp-3801	85	3	ar	ar	NOUN
fnp-3801	85	4	cells	cell	NOUN
fnp-3801	85	5	showed	show	VERB
fnp-3801	85	6	increased	increase	VERB
fnp-3801	85	7	number	number	NOUN
fnp-3801	85	8	of	of	ADP
fnp-3801	85	9	bursts	burst	NOUN
fnp-3801	85	10	,	,	PUNCT
fnp-3801	85	11	lower	low	ADJ
fnp-3801	85	12	synchrony	synchrony	NOUN
fnp-3801	85	13	and	and	CCONJ
fnp-3801	85	14	increased	increase	VERB
fnp-3801	85	15	variability	variability	NOUN
fnp-3801	85	16	compared	compare	VERB
fnp-3801	85	17	with	with	ADP
fnp-3801	85	18	nova1hu	nova1hu	PROPN
fnp-3801	85	19	/	/	SYM
fnp-3801	85	20	hu	hu	PROPN
fnp-3801	85	21	organoids	organoid	NOUN
fnp-3801	85	22	(	(	PUNCT
fnp-3801	85	23	fig	fig	NOUN
fnp-3801	85	24	.	.	PUNCT
fnp-3801	85	25	1	1	NUM
fnp-3801	85	26	)	)	PUNCT
fnp-3801	85	27	.	.	PUNCT
fnp-3801	86	1	overall	overall	ADV
fnp-3801	86	2	,	,	PUNCT
fnp-3801	86	3	their	their	PRON
fnp-3801	86	4	results	result	NOUN
fnp-3801	86	5	suggest	suggest	VERB
fnp-3801	86	6	that	that	SCONJ
fnp-3801	86	7	the	the	DET
fnp-3801	86	8	archaic	archaic	ADJ
fnp-3801	86	9	nova1	nova1	NOUN
fnp-3801	86	10	variant	variant	NOUN
fnp-3801	86	11	causes	cause	VERB
fnp-3801	86	12	changes	change	NOUN
fnp-3801	86	13	in	in	ADP
fnp-3801	86	14	alternative	alternative	ADJ
fnp-3801	86	15	splicing	splicing	NOUN
fnp-3801	86	16	of	of	ADP
fnp-3801	86	17	genes	gene	NOUN
fnp-3801	86	18	involved	involve	VERB
fnp-3801	86	19	in	in	ADP
fnp-3801	86	20	brain	brain	NOUN
fnp-3801	86	21	development	development	NOUN
fnp-3801	86	22	,	,	PUNCT
fnp-3801	86	23	proliferation	proliferation	NOUN
fnp-3801	86	24	and	and	CCONJ
fnp-3801	86	25	synaptic	synaptic	ADJ
fnp-3801	86	26	plasticity	plasticity	NOUN
fnp-3801	86	27	that	that	PRON
fnp-3801	86	28	might	might	AUX
fnp-3801	86	29	explain	explain	VERB
fnp-3801	86	30	how	how	SCONJ
fnp-3801	86	31	mutations	mutation	NOUN
fnp-3801	86	32	of	of	ADP
fnp-3801	86	33	the	the	DET
fnp-3801	86	34	nova1	nova1	NOUN
fnp-3801	86	35	gene	gene	NOUN
fnp-3801	86	36	can	can	AUX
fnp-3801	86	37	contribute	contribute	VERB
fnp-3801	86	38	to	to	ADP
fnp-3801	86	39	different	different	ADJ
fnp-3801	86	40	alterations	alteration	NOUN
fnp-3801	86	41	in	in	ADP
fnp-3801	86	42	ndds	ndd	NOUN
fnp-3801	86	43	.	.	PUNCT
fnp-3801	87	1	specifically	specifically	ADV
fnp-3801	87	2	,	,	PUNCT
fnp-3801	87	3	nova1	nova1	VERB
fnp-3801	87	4	would	would	AUX
fnp-3801	87	5	negatively	negatively	ADV
fnp-3801	87	6	impact	impact	VERB
fnp-3801	87	7	neuronal	neuronal	ADJ
fnp-3801	87	8	proliferation	proliferation	NOUN
fnp-3801	87	9	and	and	CCONJ
fnp-3801	87	10	survival	survival	NOUN
fnp-3801	87	11	,	,	PUNCT
fnp-3801	87	12	but	but	CCONJ
fnp-3801	87	13	also	also	ADV
fnp-3801	87	14	synaptic	synaptic	ADJ
fnp-3801	87	15	connectivity	connectivity	NOUN
fnp-3801	87	16	as	as	ADP
fnp-3801	87	17	a	a	DET
fnp-3801	87	18	result	result	NOUN
fnp-3801	87	19	of	of	ADP
fnp-3801	87	20	the	the	DET
fnp-3801	87	21	reduced	reduce	VERB
fnp-3801	87	22	expression	expression	NOUN
fnp-3801	87	23	of	of	ADP
fnp-3801	87	24	proteins	protein	NOUN
fnp-3801	87	25	important	important	ADJ
fnp-3801	87	26	for	for	ADP
fnp-3801	87	27	activity	activity	NOUN
fnp-3801	87	28	-	-	PUNCT
fnp-3801	87	29	dependent	dependent	ADJ
fnp-3801	87	30	plasticity	plasticity	NOUN
fnp-3801	87	31	.	.	PUNCT
fnp-3801	88	1	this	this	DET
fnp-3801	88	2	new	new	ADJ
fnp-3801	88	3	study	study	NOUN
fnp-3801	88	4	helps	help	VERB
fnp-3801	88	5	disentangle	disentangle	VERB
fnp-3801	88	6	the	the	DET
fnp-3801	88	7	evolutionary	evolutionary	ADJ
fnp-3801	88	8	origins	origin	NOUN
fnp-3801	88	9	of	of	ADP
fnp-3801	88	10	ndds	ndd	NOUN
fnp-3801	88	11	,	,	PUNCT
fnp-3801	88	12	also	also	ADV
fnp-3801	88	13	pointing	point	VERB
fnp-3801	88	14	to	to	ADP
fnp-3801	88	15	relevant	relevant	ADJ
fnp-3801	88	16	biological	biological	ADJ
fnp-3801	88	17	processes	process	NOUN
fnp-3801	88	18	.	.	PUNCT
fnp-3801	89	1	fig	fig	NOUN
fnp-3801	89	2	.	.	PUNCT
fnp-3801	90	1	1	1	NUM
fnp-3801	90	2	.	.	X
fnp-3801	90	3	schematic	schematic	ADJ
fnp-3801	90	4	representation	representation	NOUN
fnp-3801	90	5	of	of	ADP
fnp-3801	90	6	how	how	SCONJ
fnp-3801	90	7	the	the	DET
fnp-3801	90	8	archaic	archaic	ADJ
fnp-3801	90	9	nova1	nova1	X
fnp-3801	90	10	variant	variant	NOUN
fnp-3801	90	11	affects	affect	VERB
fnp-3801	90	12	cellular	cellular	ADJ
fnp-3801	90	13	,	,	PUNCT
fnp-3801	90	14	molecular	molecular	ADJ
fnp-3801	90	15	and	and	CCONJ
fnp-3801	90	16	neuronal	neuronal	ADJ
fnp-3801	90	17	network	network	NOUN
fnp-3801	90	18	activity	activity	NOUN
fnp-3801	90	19	in	in	ADP
fnp-3801	90	20	cortical	cortical	ADJ
fnp-3801	90	21	organoids	organoid	NOUN
fnp-3801	90	22	.	.	PUNCT
fnp-3801	91	1	a	a	X
fnp-3801	91	2	)	)	PUNCT
fnp-3801	91	3	nova1	nova1	NOUN
fnp-3801	91	4	archaic	archaic	ADJ
fnp-3801	91	5	version	version	NOUN
fnp-3801	91	6	was	be	AUX
fnp-3801	91	7	introduced	introduce	VERB
fnp-3801	91	8	in	in	ADP
fnp-3801	91	9	ipscs	ipsc	NOUN
fnp-3801	91	10	derived	derive	VERB
fnp-3801	91	11	from	from	ADP
fnp-3801	91	12	humans	human	NOUN
fnp-3801	91	13	.	.	PUNCT
fnp-3801	92	1	nova1hu	nova1hu	PROPN
fnp-3801	92	2	/	/	SYM
fnp-3801	92	3	hu	hu	PROPN
fnp-3801	92	4	and	and	CCONJ
fnp-3801	92	5	nova1ar	nova1ar	PROPN
fnp-3801	92	6	/	/	SYM
fnp-3801	92	7	ar	ar	PROPN
fnp-3801	92	8	hipscs	hipsc	NOUN
fnp-3801	92	9	were	be	AUX
fnp-3801	92	10	differentiated	differentiate	VERB
fnp-3801	92	11	into	into	ADP
fnp-3801	92	12	cortical	cortical	ADJ
fnp-3801	92	13	organoids	organoid	NOUN
fnp-3801	92	14	and	and	CCONJ
fnp-3801	92	15	their	their	PRON
fnp-3801	92	16	cellular	cellular	ADJ
fnp-3801	92	17	,	,	PUNCT
fnp-3801	92	18	molecular	molecular	ADJ
fnp-3801	92	19	and	and	CCONJ
fnp-3801	92	20	physiology	physiology	NOUN
fnp-3801	92	21	were	be	AUX
fnp-3801	92	22	studied	study	VERB
fnp-3801	92	23	.	.	PUNCT
fnp-3801	93	1	b	b	X
fnp-3801	93	2	)	)	PUNCT
fnp-3801	93	3	size	size	NOUN
fnp-3801	93	4	of	of	ADP
fnp-3801	93	5	nova1ar	nova1ar	PROPN
fnp-3801	93	6	/	/	SYM
fnp-3801	93	7	ar	ar	NOUN
fnp-3801	93	8	organoids	organoid	NOUN
fnp-3801	93	9	was	be	AUX
fnp-3801	93	10	smaller	small	ADJ
fnp-3801	93	11	than	than	ADP
fnp-3801	93	12	nova1ar	nova1ar	PROPN
fnp-3801	93	13	/	/	SYM
fnp-3801	93	14	ar	ar	NOUN
fnp-3801	93	15	organoids	organoid	NOUN
fnp-3801	93	16	due	due	ADJ
fnp-3801	93	17	to	to	ADP
fnp-3801	93	18	decreased	decrease	VERB
fnp-3801	93	19	neuronal	neuronal	ADJ
fnp-3801	93	20	proliferation	proliferation	NOUN
fnp-3801	93	21	and	and	CCONJ
fnp-3801	93	22	increased	increase	VERB
fnp-3801	93	23	apoptosis	apoptosis	NOUN
fnp-3801	93	24	.	.	PUNCT
fnp-3801	94	1	single	single	ADJ
fnp-3801	94	2	-	-	PUNCT
fnp-3801	94	3	nuclei	nuclei	PROPN
fnp-3801	94	4	rna	rna	NOUN
fnp-3801	94	5	-	-	PUNCT
fnp-3801	94	6	seq	seq	NOUN
fnp-3801	94	7	revealed	reveal	VERB
fnp-3801	94	8	reduced	reduced	ADJ
fnp-3801	94	9	levels	level	NOUN
fnp-3801	94	10	of	of	ADP
fnp-3801	94	11	synaptic	synaptic	ADJ
fnp-3801	94	12	proteins	protein	NOUN
fnp-3801	94	13	such	such	ADJ
fnp-3801	94	14	as	as	ADP
fnp-3801	94	15	psd95	psd95	NOUN
fnp-3801	94	16	.	.	PUNCT
fnp-3801	95	1	the	the	DET
fnp-3801	95	2	study	study	NOUN
fnp-3801	95	3	of	of	ADP
fnp-3801	95	4	electrophysiological	electrophysiological	ADJ
fnp-3801	95	5	properties	property	NOUN
fnp-3801	95	6	by	by	ADP
fnp-3801	95	7	means	mean	NOUN
fnp-3801	95	8	of	of	ADP
fnp-3801	95	9	a	a	DET
fnp-3801	95	10	multielectrode	multielectrode	NOUN
fnp-3801	95	11	array	array	NOUN
fnp-3801	95	12	revealed	reveal	VERB
fnp-3801	95	13	an	an	DET
fnp-3801	95	14	increased	increase	VERB
fnp-3801	95	15	burst	burst	ADJ
fnp-3801	95	16	activity	activity	NOUN
fnp-3801	95	17	in	in	ADP
fnp-3801	95	18	nova1ar	nova1ar	PROPN
fnp-3801	95	19	/	/	SYM
fnp-3801	95	20	ar	ar	NOUN
fnp-3801	95	21	cells	cell	NOUN
fnp-3801	95	22	along	along	ADP
fnp-3801	95	23	with	with	ADP
fnp-3801	95	24	higher	high	ADJ
fnp-3801	95	25	variability	variability	NOUN
fnp-3801	95	26	and	and	CCONJ
fnp-3801	95	27	reduced	reduced	ADJ
fnp-3801	95	28	levels	level	NOUN
fnp-3801	95	29	of	of	ADP
fnp-3801	95	30	synchrony	synchrony	NOUN
fnp-3801	95	31	when	when	SCONJ
fnp-3801	95	32	compared	compare	VERB
fnp-3801	95	33	to	to	ADP
fnp-3801	95	34	nova1hu	nova1hu	PROPN
fnp-3801	95	35	/	/	SYM
fnp-3801	95	36	hu	hu	PROPN
fnp-3801	95	37	.	.	PUNCT
fnp-3801	96	1	new	new	ADJ
fnp-3801	96	2	3d	3d	PROPN
fnp-3801	96	3	in	in	ADP
fnp-3801	96	4	vitro	vitro	X
fnp-3801	96	5	models	model	NOUN
fnp-3801	96	6	to	to	PART
fnp-3801	96	7	unveil	unveil	VERB
fnp-3801	96	8	neuropathological	neuropathological	ADJ
fnp-3801	96	9	mechanisms	mechanism	NOUN
fnp-3801	96	10	of	of	ADP
fnp-3801	96	11	human	human	ADJ
fnp-3801	96	12	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	96	13	disorders	disorder	NOUN
fnp-3801	96	14	until	until	ADP
fnp-3801	96	15	recently	recently	ADV
fnp-3801	96	16	,	,	PUNCT
fnp-3801	96	17	the	the	DET
fnp-3801	96	18	study	study	NOUN
fnp-3801	96	19	of	of	ADP
fnp-3801	96	20	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	96	21	disorders	disorder	NOUN
fnp-3801	96	22	(	(	PUNCT
fnp-3801	96	23	ndds	ndds	PROPN
fnp-3801	96	24	)	)	PUNCT
fnp-3801	96	25	has	have	AUX
fnp-3801	96	26	mainly	mainly	ADV
fnp-3801	96	27	relied	rely	VERB
fnp-3801	96	28	on	on	ADP
fnp-3801	96	29	in	in	ADP
fnp-3801	96	30	vivo	vivo	NOUN
fnp-3801	96	31	animal	animal	NOUN
fnp-3801	96	32	models	model	NOUN
fnp-3801	96	33	to	to	PART
fnp-3801	96	34	characterize	characterize	VERB
fnp-3801	96	35	the	the	DET
fnp-3801	96	36	changes	change	NOUN
fnp-3801	96	37	occurring	occur	VERB
fnp-3801	96	38	during	during	ADP
fnp-3801	96	39	early	early	ADJ
fnp-3801	96	40	brain	brain	NOUN
fnp-3801	96	41	development	development	NOUN
fnp-3801	96	42	.	.	PUNCT
fnp-3801	97	1	however	however	ADV
fnp-3801	97	2	,	,	PUNCT
fnp-3801	97	3	the	the	DET
fnp-3801	97	4	establishment	establishment	NOUN
fnp-3801	97	5	of	of	ADP
fnp-3801	97	6	in	in	ADP
fnp-3801	97	7	vitro	vitro	X
fnp-3801	97	8	models	model	NOUN
fnp-3801	97	9	of	of	ADP
fnp-3801	97	10	brain	brain	NOUN
fnp-3801	97	11	development	development	NOUN
fnp-3801	97	12	derived	derive	VERB
fnp-3801	97	13	from	from	ADP
fnp-3801	97	14	hipscs	hipsc	NOUN
fnp-3801	97	15	represents	represent	VERB
fnp-3801	97	16	an	an	DET
fnp-3801	97	17	unprecedented	unprecedented	ADJ
fnp-3801	97	18	opportunity	opportunity	NOUN
fnp-3801	97	19	to	to	PART
fnp-3801	97	20	study	study	VERB
fnp-3801	97	21	key	key	ADJ
fnp-3801	97	22	brain	brain	NOUN
fnp-3801	97	23	developmental	developmental	ADJ
fnp-3801	97	24	processes	process	NOUN
fnp-3801	97	25	,	,	PUNCT
fnp-3801	97	26	such	such	ADJ
fnp-3801	97	27	as	as	ADP
fnp-3801	97	28	neuronal	neuronal	ADJ
fnp-3801	97	29	cell	cell	NOUN
fnp-3801	97	30	morphogenesis	morphogenesis	NOUN
fnp-3801	97	31	,	,	PUNCT
fnp-3801	97	32	migration	migration	NOUN
fnp-3801	97	33	and	and	CCONJ
fnp-3801	97	34	connectivity	connectivity	NOUN
fnp-3801	97	35	in	in	ADP
fnp-3801	97	36	human	human	ADJ
fnp-3801	97	37	tissue	tissue	NOUN
fnp-3801	97	38	.	.	PUNCT
fnp-3801	98	1	although	although	SCONJ
fnp-3801	98	2	this	this	DET
fnp-3801	98	3	field	field	NOUN
fnp-3801	98	4	is	be	AUX
fnp-3801	98	5	still	still	ADV
fnp-3801	98	6	in	in	ADP
fnp-3801	98	7	its	its	PRON
fnp-3801	98	8	infancy	infancy	NOUN
fnp-3801	98	9	,	,	PUNCT
fnp-3801	98	10	an	an	DET
fnp-3801	98	11	increasing	increase	VERB
fnp-3801	98	12	number	number	NOUN
fnp-3801	98	13	of	of	ADP
fnp-3801	98	14	studies	study	NOUN
fnp-3801	98	15	demonstrate	demonstrate	VERB
fnp-3801	98	16	its	its	PRON
fnp-3801	98	17	potential	potential	NOUN
fnp-3801	98	18	to	to	PART
fnp-3801	98	19	shed	shed	VERB
fnp-3801	98	20	light	light	NOUN
fnp-3801	98	21	on	on	ADP
fnp-3801	98	22	the	the	DET
fnp-3801	98	23	mechanisms	mechanism	NOUN
fnp-3801	98	24	underlying	underlie	VERB
fnp-3801	98	25	ndds	ndd	NOUN
fnp-3801	98	26	.	.	PUNCT
fnp-3801	99	1	this	this	DET
fnp-3801	99	2	potential	potential	NOUN
fnp-3801	99	3	is	be	AUX
fnp-3801	99	4	illustrated	illustrate	VERB
fnp-3801	99	5	by	by	ADP
fnp-3801	99	6	recent	recent	ADJ
fnp-3801	99	7	advances	advance	NOUN
fnp-3801	99	8	in	in	ADP
fnp-3801	99	9	the	the	DET
fnp-3801	99	10	study	study	NOUN
fnp-3801	99	11	of	of	ADP
fnp-3801	99	12	rett	rett	PROPN
fnp-3801	99	13	syndrome	syndrome	PROPN
fnp-3801	99	14	(	(	PUNCT
fnp-3801	99	15	rtt	rtt	PROPN
fnp-3801	99	16	)	)	PUNCT
fnp-3801	99	17	,	,	PUNCT
fnp-3801	99	18	a	a	DET
fnp-3801	99	19	ndd	ndd	NOUN
fnp-3801	99	20	characterized	characterize	VERB
fnp-3801	99	21	by	by	ADP
fnp-3801	99	22	cognitive	cognitive	ADJ
fnp-3801	99	23	,	,	PUNCT
fnp-3801	99	24	speech	speech	NOUN
fnp-3801	99	25	,	,	PUNCT
fnp-3801	99	26	behavioral	behavioral	ADJ
fnp-3801	99	27	and	and	CCONJ
fnp-3801	99	28	motor	motor	NOUN
fnp-3801	99	29	problems	problem	NOUN
fnp-3801	99	30	,	,	PUNCT
fnp-3801	99	31	that	that	PRON
fnp-3801	99	32	starts	start	VERB
fnp-3801	99	33	in	in	ADP
fnp-3801	99	34	the	the	DET
fnp-3801	99	35	first	first	ADJ
fnp-3801	99	36	year	year	NOUN
fnp-3801	99	37	of	of	ADP
fnp-3801	99	38	life	life	NOUN
fnp-3801	99	39	and	and	CCONJ
fnp-3801	99	40	that	that	PRON
fnp-3801	99	41	predominantly	predominantly	ADV
fnp-3801	99	42	affects	affect	VERB
fnp-3801	99	43	females	female	NOUN
fnp-3801	99	44	.	.	PUNCT
fnp-3801	100	1	rett	rett	PROPN
fnp-3801	100	2	syndrome	syndrome	PROPN
fnp-3801	100	3	is	be	AUX
fnp-3801	100	4	a	a	DET
fnp-3801	100	5	rare	rare	ADJ
fnp-3801	100	6	and	and	CCONJ
fnp-3801	100	7	complex	complex	ADJ
fnp-3801	100	8	x	x	ADV
fnp-3801	100	9	-	-	ADJ
fnp-3801	100	10	linked	link	VERB
fnp-3801	100	11	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	100	12	disorder	disorder	NOUN
fnp-3801	100	13	associated	associate	VERB
fnp-3801	100	14	with	with	ADP
fnp-3801	100	15	mutations	mutation	NOUN
fnp-3801	100	16	in	in	ADP
fnp-3801	100	17	methyl	methyl	NOUN
fnp-3801	100	18	cpg	cpg	NOUN
fnp-3801	100	19	binding	bind	VERB
fnp-3801	100	20	protein	protein	NOUN
fnp-3801	100	21	2	2	NUM
fnp-3801	100	22	(	(	PUNCT
fnp-3801	100	23	mecp2	mecp2	NOUN
fnp-3801	100	24	)	)	PUNCT
fnp-3801	100	25	that	that	PRON
fnp-3801	100	26	cause	cause	VERB
fnp-3801	100	27	its	its	PRON
fnp-3801	100	28	loss	loss	NOUN
fnp-3801	100	29	of	of	ADP
fnp-3801	100	30	function	function	NOUN
fnp-3801	100	31	.	.	PUNCT
fnp-3801	101	1	mecp2	mecp2	NOUN
fnp-3801	101	2	is	be	AUX
fnp-3801	101	3	an	an	DET
fnp-3801	101	4	epigenetic	epigenetic	ADJ
fnp-3801	101	5	reader	reader	NOUN
fnp-3801	101	6	that	that	PRON
fnp-3801	101	7	binds	bind	VERB
fnp-3801	101	8	to	to	ADP
fnp-3801	101	9	methylated	methylate	VERB
fnp-3801	101	10	dna	dna	NOUN
fnp-3801	101	11	to	to	PART
fnp-3801	101	12	promote	promote	VERB
fnp-3801	101	13	transcriptional	transcriptional	ADJ
fnp-3801	101	14	repression	repression	NOUN
fnp-3801	101	15	.	.	PUNCT
fnp-3801	102	1	male	male	ADJ
fnp-3801	102	2	homozygous	homozygous	ADJ
fnp-3801	102	3	mecp2-/y	mecp2-/y	PROPN
fnp-3801	102	4	mice	mouse	NOUN
fnp-3801	102	5	are	be	AUX
fnp-3801	102	6	the	the	DET
fnp-3801	102	7	most	most	ADV
fnp-3801	102	8	frequently	frequently	ADV
fnp-3801	102	9	used	use	VERB
fnp-3801	102	10	rtt	rtt	NOUN
fnp-3801	102	11	model	model	NOUN
fnp-3801	102	12	due	due	ADP
fnp-3801	102	13	to	to	ADP
fnp-3801	102	14	the	the	DET
fnp-3801	102	15	early	early	ADJ
fnp-3801	102	16	development	development	NOUN
fnp-3801	102	17	of	of	ADP
fnp-3801	102	18	severe	severe	ADJ
fnp-3801	102	19	phenotypes	phenotype	NOUN
fnp-3801	102	20	,	,	PUNCT
fnp-3801	102	21	but	but	CCONJ
fnp-3801	102	22	even	even	ADV
fnp-3801	102	23	though	though	SCONJ
fnp-3801	102	24	the	the	DET
fnp-3801	102	25	use	use	NOUN
fnp-3801	102	26	of	of	ADP
fnp-3801	102	27	these	these	DET
fnp-3801	102	28	models	model	NOUN
fnp-3801	102	29	has	have	AUX
fnp-3801	102	30	significantly	significantly	ADV
fnp-3801	102	31	contributed	contribute	VERB
fnp-3801	102	32	to	to	ADP
fnp-3801	102	33	the	the	DET
fnp-3801	102	34	understanding	understanding	NOUN
fnp-3801	102	35	of	of	ADP
fnp-3801	102	36	the	the	DET
fnp-3801	102	37	mechanisms	mechanism	NOUN
fnp-3801	102	38	underlying	underlie	VERB
fnp-3801	102	39	rtt	rtt	NOUN
fnp-3801	102	40	,	,	PUNCT
fnp-3801	102	41	their	their	PRON
fnp-3801	102	42	clinical	clinical	ADJ
fnp-3801	102	43	relevance	relevance	NOUN
fnp-3801	102	44	might	might	AUX
fnp-3801	102	45	be	be	AUX
fnp-3801	102	46	limited	limit	VERB
fnp-3801	102	47	.	.	PUNCT
fnp-3801	103	1	in	in	ADP
fnp-3801	103	2	fact	fact	NOUN
fnp-3801	103	3	,	,	PUNCT
fnp-3801	103	4	their	their	PRON
fnp-3801	103	5	face	face	NOUN
fnp-3801	103	6	validity	validity	NOUN
fnp-3801	103	7	is	be	AUX
fnp-3801	103	8	constrained	constrain	VERB
fnp-3801	103	9	as	as	SCONJ
fnp-3801	103	10	male	male	ADJ
fnp-3801	103	11	mice	mouse	NOUN
fnp-3801	103	12	are	be	AUX
fnp-3801	103	13	used	use	VERB
fnp-3801	103	14	to	to	PART
fnp-3801	103	15	model	model	VERB
fnp-3801	103	16	a	a	DET
fnp-3801	103	17	disease	disease	NOUN
fnp-3801	103	18	mainly	mainly	ADV
fnp-3801	103	19	affecting	affect	VERB
fnp-3801	103	20	females	female	NOUN
fnp-3801	103	21	,	,	PUNCT
fnp-3801	103	22	and	and	CCONJ
fnp-3801	103	23	female	female	ADJ
fnp-3801	103	24	patients	patient	NOUN
fnp-3801	103	25	have	have	VERB
fnp-3801	103	26	a	a	DET
fnp-3801	103	27	milder	mild	ADJ
fnp-3801	103	28	phenotype	phenotype	NOUN
fnp-3801	103	29	than	than	ADP
fnp-3801	103	30	the	the	DET
fnp-3801	103	31	one	one	NUM
fnp-3801	103	32	observed	observe	VERB
fnp-3801	103	33	in	in	ADP
fnp-3801	103	34	mice	mouse	NOUN
fnp-3801	103	35	.	.	PUNCT
fnp-3801	104	1	to	to	PART
fnp-3801	104	2	overcome	overcome	VERB
fnp-3801	104	3	these	these	DET
fnp-3801	104	4	limitations	limitation	NOUN
fnp-3801	104	5	,	,	PUNCT
fnp-3801	104	6	several	several	ADJ
fnp-3801	104	7	methodologies	methodology	NOUN
fnp-3801	104	8	have	have	AUX
fnp-3801	104	9	been	be	AUX
fnp-3801	104	10	established	establish	VERB
fnp-3801	104	11	to	to	PART
fnp-3801	104	12	model	model	VERB
fnp-3801	104	13	rtt	rtt	PROPN
fnp-3801	104	14	with	with	ADP
fnp-3801	104	15	hipscs	hipsc	NOUN
fnp-3801	104	16	from	from	ADP
fnp-3801	104	17	patients	patient	NOUN
fnp-3801	104	18	by	by	ADP
fnp-3801	104	19	developing	develop	VERB
fnp-3801	104	20	2d	2d	NOUN
fnp-3801	104	21	-	-	PUNCT
fnp-3801	104	22	based	base	VERB
fnp-3801	104	23	neuronal	neuronal	ADJ
fnp-3801	104	24	differentiation	differentiation	NOUN
fnp-3801	104	25	protocols	protocol	NOUN
fnp-3801	104	26	.	.	PUNCT
fnp-3801	105	1	more	more	ADV
fnp-3801	105	2	recently	recently	ADV
fnp-3801	105	3	,	,	PUNCT
fnp-3801	105	4	the	the	DET
fnp-3801	105	5	generation	generation	NOUN
fnp-3801	105	6	of	of	ADP
fnp-3801	105	7	3d	3d	PROPN
fnp-3801	105	8	human	human	ADJ
fnp-3801	105	9	brain	brain	NOUN
fnp-3801	105	10	organoids	organoid	NOUN
fnp-3801	105	11	,	,	PUNCT
fnp-3801	105	12	a	a	DET
fnp-3801	105	13	more	more	ADV
fnp-3801	105	14	complex	complex	ADJ
fnp-3801	105	15	approach	approach	NOUN
fnp-3801	105	16	that	that	PRON
fnp-3801	105	17	better	well	ADJ
fnp-3801	105	18	recapitulates	recapitulate	VERB
fnp-3801	105	19	human	human	ADJ
fnp-3801	105	20	neurodevelopment	neurodevelopment	NOUN
fnp-3801	105	21	in	in	ADP
fnp-3801	105	22	vitro	vitro	X
fnp-3801	105	23	,	,	PUNCT
fnp-3801	105	24	has	have	AUX
fnp-3801	105	25	been	be	AUX
fnp-3801	105	26	established	establish	VERB
fnp-3801	105	27	.	.	PUNCT
fnp-3801	106	1	these	these	DET
fnp-3801	106	2	culture	culture	NOUN
fnp-3801	106	3	platforms	platform	NOUN
fnp-3801	106	4	are	be	AUX
fnp-3801	106	5	increasingly	increasingly	ADV
fnp-3801	106	6	contributing	contribute	VERB
fnp-3801	106	7	to	to	ADP
fnp-3801	106	8	a	a	DET
fnp-3801	106	9	better	well	ADJ
fnp-3801	106	10	understanding	understanding	NOUN
fnp-3801	106	11	of	of	ADP
fnp-3801	106	12	the	the	DET
fnp-3801	106	13	rtt	rtt	PROPN
fnp-3801	106	14	etiology	etiology	NOUN
fnp-3801	106	15	.	.	PUNCT
fnp-3801	107	1	the	the	DET
fnp-3801	107	2	tremendous	tremendous	ADJ
fnp-3801	107	3	potential	potential	NOUN
fnp-3801	107	4	of	of	ADP
fnp-3801	107	5	such	such	ADJ
fnp-3801	107	6	methodologies	methodology	NOUN
fnp-3801	107	7	is	be	AUX
fnp-3801	107	8	illustrated	illustrate	VERB
fnp-3801	107	9	by	by	ADP
fnp-3801	107	10	the	the	DET
fnp-3801	107	11	recent	recent	ADJ
fnp-3801	107	12	work	work	NOUN
fnp-3801	107	13	of	of	ADP
fnp-3801	107	14	samarasinghe	samarasinghe	NOUN
fnp-3801	107	15	et	et	PROPN
fnp-3801	107	16	al	al	PROPN
fnp-3801	107	17	.	.	PUNCT
fnp-3801	108	1	[	[	X
fnp-3801	108	2	19	19	NUM
fnp-3801	108	3	]	]	PUNCT
fnp-3801	108	4	who	who	PRON
fnp-3801	108	5	showed	show	VERB
fnp-3801	108	6	that	that	SCONJ
fnp-3801	108	7	brain	brain	NOUN
fnp-3801	108	8	organoids	organoid	NOUN
fnp-3801	108	9	derived	derive	VERB
fnp-3801	108	10	from	from	ADP
fnp-3801	108	11	induced	induced	ADJ
fnp-3801	108	12	pluripotent	pluripotent	ADJ
fnp-3801	108	13	stem	stem	NOUN
fnp-3801	108	14	cells	cell	NOUN
fnp-3801	108	15	from	from	ADP
fnp-3801	108	16	individuals	individual	NOUN
fnp-3801	108	17	with	with	ADP
fnp-3801	108	18	rtt	rtt	NOUN
fnp-3801	108	19	reproduce	reproduce	NOUN
fnp-3801	108	20	patterns	pattern	NOUN
fnp-3801	108	21	of	of	ADP
fnp-3801	108	22	electrical	electrical	ADJ
fnp-3801	108	23	brain	brain	NOUN
fnp-3801	108	24	activity	activity	NOUN
fnp-3801	108	25	that	that	PRON
fnp-3801	108	26	resembled	resemble	VERB
fnp-3801	108	27	seizures	seizure	NOUN
fnp-3801	108	28	,	,	PUNCT
fnp-3801	108	29	a	a	DET
fnp-3801	108	30	hallmark	hallmark	NOUN
fnp-3801	108	31	of	of	ADP
fnp-3801	108	32	the	the	DET
fnp-3801	108	33	condition	condition	NOUN
fnp-3801	108	34	.	.	PUNCT
fnp-3801	109	1	using	use	VERB
fnp-3801	109	2	calcium	calcium	NOUN
fnp-3801	109	3	sensor	sensor	NOUN
fnp-3801	109	4	imaging	imaging	NOUN
fnp-3801	109	5	and	and	CCONJ
fnp-3801	109	6	extracellular	extracellular	ADJ
fnp-3801	109	7	recording	recording	NOUN
fnp-3801	109	8	approaches	approach	NOUN
fnp-3801	109	9	,	,	PUNCT
fnp-3801	109	10	they	they	PRON
fnp-3801	109	11	demonstrated	demonstrate	VERB
fnp-3801	109	12	highly	highly	ADV
fnp-3801	109	13	abnormal	abnormal	ADJ
fnp-3801	109	14	and	and	CCONJ
fnp-3801	109	15	epileptiform	epileptiform	NOUN
fnp-3801	109	16	-	-	PUNCT
fnp-3801	109	17	like	like	ADJ
fnp-3801	109	18	activity	activity	NOUN
fnp-3801	109	19	,	,	PUNCT
fnp-3801	109	20	accompanied	accompany	VERB
fnp-3801	109	21	by	by	ADP
fnp-3801	109	22	transcriptomic	transcriptomic	ADJ
fnp-3801	109	23	differences	difference	NOUN
fnp-3801	109	24	revealed	reveal	VERB
fnp-3801	109	25	by	by	ADP
fnp-3801	109	26	single	single	ADJ
fnp-3801	109	27	-	-	PUNCT
fnp-3801	109	28	cell	cell	NOUN
fnp-3801	109	29	analyses	analysis	NOUN
fnp-3801	109	30	.	.	PUNCT
fnp-3801	110	1	interestingly	interestingly	ADV
fnp-3801	110	2	,	,	PUNCT
fnp-3801	110	3	trujillo	trujillo	PROPN
fnp-3801	110	4	et	et	PROPN
fnp-3801	110	5	al	al	PROPN
fnp-3801	110	6	.	.	PUNCT
fnp-3801	111	1	[	[	X
fnp-3801	111	2	20	20	NUM
fnp-3801	111	3	]	]	PUNCT
fnp-3801	111	4	used	use	VERB
fnp-3801	111	5	an	an	DET
fnp-3801	111	6	innovative	innovative	ADJ
fnp-3801	111	7	pipeline	pipeline	NOUN
fnp-3801	111	8	to	to	PART
fnp-3801	111	9	model	model	VERB
fnp-3801	111	10	rtt	rtt	PROPN
fnp-3801	111	11	neurodevelopment	neurodevelopment	ADJ
fnp-3801	111	12	demonstrating	demonstrating	NOUN
fnp-3801	111	13	that	that	SCONJ
fnp-3801	111	14	neurons	neuron	NOUN
fnp-3801	111	15	differentiated	differentiate	VERB
fnp-3801	111	16	from	from	ADP
fnp-3801	111	17	human	human	ADJ
fnp-3801	111	18	mecp2	mecp2	NOUN
fnp-3801	111	19	-	-	PUNCT
fnp-3801	111	20	ko	ko	PROPN
fnp-3801	111	21	hipscs	hipscs	PROPN
fnp-3801	111	22	show	show	VERB
fnp-3801	111	23	altered	alter	VERB
fnp-3801	111	24	expression	expression	NOUN
fnp-3801	111	25	of	of	ADP
fnp-3801	111	26	synapse	synapse	NOUN
fnp-3801	111	27	-	-	PUNCT
fnp-3801	111	28	relevant	relevant	ADJ
fnp-3801	111	29	genes	gene	NOUN
fnp-3801	111	30	,	,	PUNCT
fnp-3801	111	31	synaptic	synaptic	ADJ
fnp-3801	111	32	morphology	morphology	NOUN
fnp-3801	111	33	,	,	PUNCT
fnp-3801	111	34	and	and	CCONJ
fnp-3801	111	35	decreased	decrease	VERB
fnp-3801	111	36	calcium	calcium	NOUN
fnp-3801	111	37	and	and	CCONJ
fnp-3801	111	38	network	network	NOUN
fnp-3801	111	39	activities	activity	NOUN
fnp-3801	111	40	compared	compare	VERB
fnp-3801	111	41	to	to	ADP
fnp-3801	111	42	control	control	NOUN
fnp-3801	111	43	neurons	neuron	NOUN
fnp-3801	111	44	.	.	PUNCT
fnp-3801	112	1	an	an	DET
fnp-3801	112	2	in	in	ADP
fnp-3801	112	3	silico	silico	NOUN
fnp-3801	112	4	neural	neural	ADJ
fnp-3801	112	5	network	network	NOUN
fnp-3801	112	6	simulation	simulation	NOUN
fnp-3801	112	7	affirmed	affirm	VERB
fnp-3801	112	8	that	that	SCONJ
fnp-3801	112	9	synaptic	synaptic	ADJ
fnp-3801	112	10	structural	structural	ADJ
fnp-3801	112	11	parameters	parameter	NOUN
fnp-3801	112	12	link	link	VERB
fnp-3801	112	13	with	with	ADP
fnp-3801	112	14	neural	neural	ADJ
fnp-3801	112	15	network	network	NOUN
fnp-3801	112	16	activity	activity	NOUN
fnp-3801	112	17	,	,	PUNCT
fnp-3801	112	18	supporting	support	VERB
fnp-3801	112	19	the	the	DET
fnp-3801	112	20	approach	approach	NOUN
fnp-3801	112	21	of	of	ADP
fnp-3801	112	22	rescuing	rescue	VERB
fnp-3801	112	23	synaptic	synaptic	ADJ
fnp-3801	112	24	structure	structure	NOUN
fnp-3801	112	25	and	and	CCONJ
fnp-3801	112	26	increasing	increase	VERB
fnp-3801	112	27	activity	activity	NOUN
fnp-3801	112	28	.	.	PUNCT
fnp-3801	113	1	they	they	PRON
fnp-3801	113	2	differentiated	differentiate	VERB
fnp-3801	113	3	mecp2	mecp2	NOUN
fnp-3801	113	4	-	-	PUNCT
fnp-3801	113	5	ko	ko	NOUN
fnp-3801	113	6	hipsc	hipsc	PROPN
fnp-3801	113	7	into	into	ADP
fnp-3801	113	8	in	in	ADP
fnp-3801	113	9	vitro	vitro	X
fnp-3801	113	10	models	model	NOUN
fnp-3801	113	11	of	of	ADP
fnp-3801	113	12	increasing	increase	VERB
fnp-3801	113	13	complexity	complexity	NOUN
fnp-3801	113	14	.	.	PUNCT
fnp-3801	114	1	first	first	ADV
fnp-3801	114	2	,	,	PUNCT
fnp-3801	114	3	2d	2d	NUM
fnp-3801	114	4	monolayer	monolayer	NOUN
fnp-3801	114	5	neuronal	neuronal	ADJ
fnp-3801	114	6	cultures	culture	NOUN
fnp-3801	114	7	revealed	reveal	VERB
fnp-3801	114	8	an	an	DET
fnp-3801	114	9	impaired	impaired	ADJ
fnp-3801	114	10	neurotransmission	neurotransmission	NOUN
fnp-3801	114	11	.	.	PUNCT
fnp-3801	115	1	the	the	DET
fnp-3801	115	2	same	same	ADJ
fnp-3801	115	3	hipsc	hipsc	NOUN
fnp-3801	115	4	were	be	AUX
fnp-3801	115	5	then	then	ADV
fnp-3801	115	6	used	use	VERB
fnp-3801	115	7	to	to	PART
fnp-3801	115	8	produce	produce	VERB
fnp-3801	115	9	a	a	DET
fnp-3801	115	10	novel	novel	ADJ
fnp-3801	115	11	system	system	NOUN
fnp-3801	115	12	of	of	ADP
fnp-3801	115	13	3d	3d	NUM
fnp-3801	115	14	brain	brain	NOUN
fnp-3801	115	15	neurospheres	neurosphere	NOUN
fnp-3801	115	16	derived	derive	VERB
fnp-3801	115	17	from	from	ADP
fnp-3801	115	18	a	a	DET
fnp-3801	115	19	50/50	50/50	NUM
fnp-3801	115	20	mixture	mixture	NOUN
fnp-3801	115	21	of	of	ADP
fnp-3801	115	22	healthy	healthy	ADJ
fnp-3801	115	23	and	and	CCONJ
fnp-3801	115	24	mecp2	mecp2	NOUN
fnp-3801	115	25	-	-	PUNCT
fnp-3801	115	26	ko	ko	NOUN
fnp-3801	115	27	hipsc	hipsc	PROPN
fnp-3801	115	28	to	to	PART
fnp-3801	115	29	better	well	ADV
fnp-3801	115	30	mimic	mimic	VERB
fnp-3801	115	31	the	the	DET
fnp-3801	115	32	mosaicism	mosaicism	NOUN
fnp-3801	115	33	observed	observe	VERB
fnp-3801	115	34	in	in	ADP
fnp-3801	115	35	female	female	ADJ
fnp-3801	115	36	patients	patient	NOUN
fnp-3801	115	37	,	,	PUNCT
fnp-3801	115	38	a	a	DET
fnp-3801	115	39	phenomenon	phenomenon	NOUN
fnp-3801	115	40	produced	produce	VERB
fnp-3801	115	41	by	by	ADP
fnp-3801	115	42	random	random	ADJ
fnp-3801	115	43	x	x	NOUN
fnp-3801	115	44	-	-	NOUN
fnp-3801	115	45	inactivation	inactivation	NOUN
fnp-3801	115	46	.	.	PUNCT
fnp-3801	116	1	this	this	DET
fnp-3801	116	2	new	new	ADJ
fnp-3801	116	3	model	model	NOUN
fnp-3801	116	4	will	will	AUX
fnp-3801	116	5	be	be	AUX
fnp-3801	116	6	of	of	ADP
fnp-3801	116	7	great	great	ADJ
fnp-3801	116	8	utility	utility	NOUN
fnp-3801	116	9	to	to	PART
fnp-3801	116	10	investigate	investigate	VERB
fnp-3801	116	11	rtt	rtt	NOUN
fnp-3801	116	12	and	and	CCONJ
fnp-3801	116	13	other	other	ADJ
fnp-3801	116	14	x	x	ADJ
fnp-3801	116	15	-	-	ADJ
fnp-3801	116	16	linked	link	VERB
fnp-3801	116	17	genetic	genetic	ADJ
fnp-3801	116	18	conditions	condition	NOUN
fnp-3801	116	19	.	.	PUNCT
fnp-3801	117	1	as	as	ADP
fnp-3801	117	2	a	a	DET
fnp-3801	117	3	last	last	ADJ
fnp-3801	117	4	step	step	NOUN
fnp-3801	117	5	,	,	PUNCT
fnp-3801	117	6	complex	complex	ADJ
fnp-3801	117	7	3d	3d	PROPN
fnp-3801	117	8	mecp2	mecp2	NOUN
fnp-3801	117	9	-	-	PUNCT
fnp-3801	117	10	ko	ko	NOUN
fnp-3801	117	11	cortical	cortical	ADJ
fnp-3801	117	12	organoids	organoid	NOUN
fnp-3801	117	13	were	be	AUX
fnp-3801	117	14	also	also	ADV
fnp-3801	117	15	produced	produce	VERB
fnp-3801	117	16	.	.	PUNCT
fnp-3801	118	1	interestingly	interestingly	ADV
fnp-3801	118	2	,	,	PUNCT
fnp-3801	118	3	this	this	DET
fnp-3801	118	4	pipeline	pipeline	NOUN
fnp-3801	118	5	revealed	reveal	VERB
fnp-3801	118	6	important	important	ADJ
fnp-3801	118	7	features	feature	NOUN
fnp-3801	118	8	of	of	ADP
fnp-3801	118	9	rtt	rtt	PROPN
fnp-3801	118	10	pathology	pathology	PROPN
fnp-3801	118	11	.	.	PUNCT
fnp-3801	119	1	the	the	DET
fnp-3801	119	2	researchers	researcher	NOUN
fnp-3801	119	3	found	find	VERB
fnp-3801	119	4	that	that	SCONJ
fnp-3801	119	5	rtt	rtt	PROPN
fnp-3801	119	6	organoids	organoid	NOUN
fnp-3801	119	7	displayed	display	VERB
fnp-3801	119	8	smaller	small	ADJ
fnp-3801	119	9	diameters	diameter	NOUN
fnp-3801	119	10	and	and	CCONJ
fnp-3801	119	11	both	both	DET
fnp-3801	119	12	mecp	mecp	NOUN
fnp-3801	119	13	-	-	PUNCT
fnp-3801	119	14	ko	ko	ADJ
fnp-3801	119	15	neuronal	neuronal	ADJ
fnp-3801	119	16	cultures	culture	NOUN
fnp-3801	119	17	and	and	CCONJ
fnp-3801	119	18	organoids	organoid	NOUN
fnp-3801	119	19	showed	show	VERB
fnp-3801	119	20	that	that	SCONJ
fnp-3801	119	21	synaptic	synaptic	ADJ
fnp-3801	119	22	and	and	CCONJ
fnp-3801	119	23	neurotransmitter	neurotransmitter	NOUN
fnp-3801	119	24	pathophysiology	pathophysiology	NOUN
fnp-3801	119	25	principally	principally	ADV
fnp-3801	119	26	concentrated	concentrate	VERB
fnp-3801	119	27	in	in	ADP
fnp-3801	119	28	glutamatergic	glutamatergic	ADJ
fnp-3801	119	29	and	and	CCONJ
fnp-3801	119	30	cholinergic	cholinergic	ADJ
fnp-3801	119	31	dysregulation	dysregulation	NOUN
fnp-3801	119	32	.	.	PUNCT
fnp-3801	120	1	furthermore	furthermore	ADV
fnp-3801	120	2	,	,	PUNCT
fnp-3801	120	3	nefiracetam	nefiracetam	VERB
fnp-3801	120	4	,	,	PUNCT
fnp-3801	120	5	a	a	DET
fnp-3801	120	6	cholinergic	cholinergic	NOUN
fnp-3801	120	7	,	,	PUNCT
fnp-3801	120	8	gabaergic	gabaergic	ADJ
fnp-3801	120	9	,	,	PUNCT
fnp-3801	120	10	and	and	CCONJ
fnp-3801	120	11	glutamatergic	glutamatergic	ADJ
fnp-3801	120	12	agonist	agonist	NOUN
fnp-3801	120	13	,	,	PUNCT
fnp-3801	120	14	and	and	CCONJ
fnp-3801	120	15	pha	pha	PROPN
fnp-3801	120	16	543613	543613	NUM
fnp-3801	120	17	,	,	PUNCT
fnp-3801	120	18	a	a	DET
fnp-3801	120	19	α7	α7	NOUN
fnp-3801	120	20	-	-	PUNCT
fnp-3801	120	21	nachr	nachr	NOUN
fnp-3801	120	22	agonist	agonist	NOUN
fnp-3801	120	23	,	,	PUNCT
fnp-3801	120	24	had	have	VERB
fnp-3801	120	25	a	a	DET
fnp-3801	120	26	rescuing	rescue	VERB
fnp-3801	120	27	effect	effect	NOUN
fnp-3801	120	28	supporting	support	VERB
fnp-3801	120	29	glutamatergic	glutamatergic	ADJ
fnp-3801	120	30	and	and	CCONJ
fnp-3801	120	31	cholinergic	cholinergic	ADJ
fnp-3801	120	32	dysregulation	dysregulation	NOUN
fnp-3801	120	33	.	.	PUNCT
fnp-3801	121	1	new	new	ADJ
fnp-3801	121	2	insights	insight	NOUN
fnp-3801	121	3	and	and	CCONJ
fnp-3801	121	4	tools	tool	NOUN
fnp-3801	121	5	to	to	PART
fnp-3801	121	6	explore	explore	VERB
fnp-3801	121	7	the	the	DET
fnp-3801	121	8	genome	genome	NOUN
fnp-3801	121	9	architecture	architecture	NOUN
fnp-3801	121	10	and	and	CCONJ
fnp-3801	121	11	transcriptional	transcriptional	ADJ
fnp-3801	121	12	dynamics	dynamic	NOUN
fnp-3801	121	13	in	in	ADP
fnp-3801	121	14	the	the	DET
fnp-3801	121	15	mammalian	mammalian	ADJ
fnp-3801	121	16	brain	brain	NOUN
fnp-3801	121	17	development	development	NOUN
fnp-3801	121	18	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	121	19	processes	process	NOUN
fnp-3801	121	20	rely	rely	VERB
fnp-3801	121	21	on	on	ADP
fnp-3801	121	22	the	the	DET
fnp-3801	121	23	orchestration	orchestration	NOUN
fnp-3801	121	24	of	of	ADP
fnp-3801	121	25	finely	finely	ADV
fnp-3801	121	26	tuned	tune	VERB
fnp-3801	121	27	gene	gene	NOUN
fnp-3801	121	28	expression	expression	NOUN
fnp-3801	121	29	programs	program	NOUN
fnp-3801	121	30	,	,	PUNCT
fnp-3801	121	31	which	which	PRON
fnp-3801	121	32	depend	depend	VERB
fnp-3801	121	33	on	on	ADP
fnp-3801	121	34	the	the	DET
fnp-3801	121	35	regulation	regulation	NOUN
fnp-3801	121	36	of	of	ADP
fnp-3801	121	37	chromatin	chromatin	NOUN
fnp-3801	121	38	structure	structure	NOUN
fnp-3801	121	39	.	.	PUNCT
fnp-3801	122	1	over	over	ADP
fnp-3801	122	2	the	the	DET
fnp-3801	122	3	last	last	ADJ
fnp-3801	122	4	few	few	ADJ
fnp-3801	122	5	years	year	NOUN
fnp-3801	122	6	,	,	PUNCT
fnp-3801	122	7	mutations	mutation	NOUN
fnp-3801	122	8	in	in	ADP
fnp-3801	122	9	genes	gene	NOUN
fnp-3801	122	10	encoding	encode	VERB
fnp-3801	122	11	factors	factor	NOUN
fnp-3801	122	12	that	that	PRON
fnp-3801	122	13	can	can	AUX
fnp-3801	122	14	modify	modify	VERB
fnp-3801	122	15	chromatin	chromatin	NOUN
fnp-3801	122	16	regulation	regulation	NOUN
fnp-3801	122	17	and	and	CCONJ
fnp-3801	122	18	nuclear	nuclear	ADJ
fnp-3801	122	19	architecture	architecture	NOUN
fnp-3801	122	20	have	have	AUX
fnp-3801	122	21	emerged	emerge	VERB
fnp-3801	122	22	as	as	ADP
fnp-3801	122	23	a	a	DET
fnp-3801	122	24	frequent	frequent	ADJ
fnp-3801	122	25	cause	cause	NOUN
fnp-3801	122	26	of	of	ADP
fnp-3801	122	27	ndds	ndd	NOUN
fnp-3801	122	28	.	.	PUNCT
fnp-3801	123	1	post	post	PROPN
fnp-3801	123	2	mortem	mortem	PROPN
fnp-3801	123	3	studies	study	NOUN
fnp-3801	123	4	on	on	ADP
fnp-3801	123	5	brains	brain	NOUN
fnp-3801	123	6	from	from	ADP
fnp-3801	123	7	patients	patient	NOUN
fnp-3801	123	8	with	with	ADP
fnp-3801	123	9	different	different	ADJ
fnp-3801	123	10	ndds	ndd	NOUN
fnp-3801	123	11	found	find	VERB
fnp-3801	123	12	chromatin	chromatin	NOUN
fnp-3801	123	13	and	and	CCONJ
fnp-3801	123	14	other	other	ADJ
fnp-3801	123	15	epigenetic	epigenetic	ADJ
fnp-3801	123	16	alterations	alteration	NOUN
fnp-3801	123	17	linked	link	VERB
fnp-3801	123	18	with	with	ADP
fnp-3801	123	19	abnormalities	abnormality	NOUN
fnp-3801	123	20	in	in	ADP
fnp-3801	123	21	neural	neural	ADJ
fnp-3801	123	22	development	development	NOUN
fnp-3801	123	23	.	.	PUNCT
fnp-3801	124	1	this	this	PRON
fnp-3801	124	2	is	be	AUX
fnp-3801	124	3	the	the	DET
fnp-3801	124	4	case	case	NOUN
fnp-3801	124	5	of	of	ADP
fnp-3801	124	6	opitz	opitz	NOUN
fnp-3801	124	7	-	-	PUNCT
fnp-3801	124	8	kaveggia	kaveggia	NOUN
fnp-3801	124	9	and	and	CCONJ
fnp-3801	124	10	fryns	fryns	ADJ
fnp-3801	124	11	-	-	PUNCT
fnp-3801	124	12	lujan	lujan	NOUN
fnp-3801	124	13	syndromes	syndrome	NOUN
fnp-3801	124	14	,	,	PUNCT
fnp-3801	124	15	caused	cause	VERB
fnp-3801	124	16	by	by	ADP
fnp-3801	124	17	mutations	mutation	NOUN
fnp-3801	124	18	in	in	ADP
fnp-3801	124	19	med12	med12	PROPN
fnp-3801	124	20	[	[	X
fnp-3801	124	21	21	21	NUM
fnp-3801	124	22	]	]	PUNCT
fnp-3801	124	23	,	,	PUNCT
fnp-3801	124	24	and	and	CCONJ
fnp-3801	124	25	cornelia	cornelia	PROPN
fnp-3801	124	26	de	de	PROPN
fnp-3801	124	27	lange	lange	PROPN
fnp-3801	124	28	syndrome	syndrome	NOUN
fnp-3801	124	29	,	,	PUNCT
fnp-3801	124	30	which	which	PRON
fnp-3801	124	31	results	result	VERB
fnp-3801	124	32	from	from	ADP
fnp-3801	124	33	mutations	mutation	NOUN
fnp-3801	124	34	in	in	ADP
fnp-3801	124	35	nipbl	nipbl	NOUN
fnp-3801	124	36	or	or	CCONJ
fnp-3801	124	37	in	in	ADP
fnp-3801	124	38	the	the	DET
fnp-3801	124	39	cohesin	cohesin	NOUN
fnp-3801	124	40	subunits	subunit	NOUN
fnp-3801	124	41	coding	code	VERB
fnp-3801	124	42	genes	gene	NOUN
fnp-3801	124	43	smc1	smc1	PROPN
fnp-3801	124	44	and	and	CCONJ
fnp-3801	124	45	smc3	smc3	VERB
fnp-3801	125	1	[	[	PUNCT
fnp-3801	125	2	22	22	NUM
fnp-3801	125	3	]	]	PUNCT
fnp-3801	125	4	.	.	PUNCT
fnp-3801	126	1	mutations	mutation	NOUN
fnp-3801	126	2	in	in	ADP
fnp-3801	126	3	the	the	DET
fnp-3801	126	4	ctcf	ctcf	ADJ
fnp-3801	126	5	gene	gene	NOUN
fnp-3801	126	6	are	be	AUX
fnp-3801	126	7	also	also	ADV
fnp-3801	126	8	associated	associate	VERB
fnp-3801	126	9	with	with	ADP
fnp-3801	126	10	intellectual	intellectual	ADJ
fnp-3801	126	11	disability	disability	NOUN
fnp-3801	126	12	[	[	X
fnp-3801	126	13	23	23	NUM
fnp-3801	126	14	,	,	PUNCT
fnp-3801	126	15	24	24	NUM
fnp-3801	126	16	]	]	PUNCT
fnp-3801	126	17	.	.	PUNCT
fnp-3801	127	1	on	on	ADP
fnp-3801	127	2	the	the	DET
fnp-3801	127	3	other	other	ADJ
fnp-3801	127	4	hand	hand	NOUN
fnp-3801	127	5	,	,	PUNCT
fnp-3801	127	6	our	our	PRON
fnp-3801	127	7	knowledge	knowledge	NOUN
fnp-3801	127	8	of	of	ADP
fnp-3801	127	9	the	the	DET
fnp-3801	127	10	critical	critical	ADJ
fnp-3801	127	11	role	role	NOUN
fnp-3801	127	12	of	of	ADP
fnp-3801	127	13	the	the	DET
fnp-3801	127	14	genome	genome	NOUN
fnp-3801	127	15	’s	’s	PART
fnp-3801	127	16	3d	3d	PROPN
fnp-3801	127	17	organization	organization	NOUN
fnp-3801	127	18	in	in	ADP
fnp-3801	127	19	gene	gene	NOUN
fnp-3801	127	20	regulation	regulation	NOUN
fnp-3801	127	21	is	be	AUX
fnp-3801	127	22	steadily	steadily	ADV
fnp-3801	127	23	increasing	increase	VERB
fnp-3801	127	24	.	.	PUNCT
fnp-3801	128	1	this	this	PRON
fnp-3801	128	2	is	be	AUX
fnp-3801	128	3	important	important	ADJ
fnp-3801	128	4	since	since	SCONJ
fnp-3801	128	5	the	the	DET
fnp-3801	128	6	expression	expression	NOUN
fnp-3801	128	7	of	of	ADP
fnp-3801	128	8	a	a	DET
fnp-3801	128	9	given	give	VERB
fnp-3801	128	10	gene	gene	NOUN
fnp-3801	128	11	in	in	ADP
fnp-3801	128	12	a	a	DET
fnp-3801	128	13	specific	specific	ADJ
fnp-3801	128	14	time	time	NOUN
fnp-3801	128	15	and	and	CCONJ
fnp-3801	128	16	cellular	cellular	ADJ
fnp-3801	128	17	type	type	NOUN
fnp-3801	128	18	is	be	AUX
fnp-3801	128	19	known	know	VERB
fnp-3801	128	20	to	to	PART
fnp-3801	128	21	depend	depend	VERB
fnp-3801	128	22	on	on	ADP
fnp-3801	128	23	its	its	PRON
fnp-3801	128	24	location	location	NOUN
fnp-3801	128	25	within	within	ADP
fnp-3801	128	26	the	the	DET
fnp-3801	128	27	nucleus	nucleus	NOUN
fnp-3801	128	28	and	and	CCONJ
fnp-3801	128	29	on	on	ADP
fnp-3801	128	30	its	its	PRON
fnp-3801	128	31	contacts	contact	NOUN
fnp-3801	128	32	with	with	ADP
fnp-3801	128	33	other	other	ADJ
fnp-3801	128	34	loci	loci	NOUN
fnp-3801	128	35	,	,	PUNCT
fnp-3801	128	36	forming	form	VERB
fnp-3801	128	37	topologically	topologically	ADV
fnp-3801	128	38	associated	associate	VERB
fnp-3801	128	39	domains	domain	NOUN
fnp-3801	128	40	(	(	PUNCT
fnp-3801	128	41	tads	tad	NOUN
fnp-3801	128	42	)	)	PUNCT
fnp-3801	128	43	.	.	PUNCT
fnp-3801	129	1	however	however	ADV
fnp-3801	129	2	,	,	PUNCT
fnp-3801	129	3	although	although	SCONJ
fnp-3801	129	4	previous	previous	ADJ
fnp-3801	129	5	studies	study	NOUN
fnp-3801	129	6	have	have	AUX
fnp-3801	129	7	contributed	contribute	VERB
fnp-3801	129	8	to	to	PART
fnp-3801	129	9	characterize	characterize	VERB
fnp-3801	129	10	the	the	DET
fnp-3801	129	11	transcriptome	transcriptome	NOUN
fnp-3801	129	12	and	and	CCONJ
fnp-3801	129	13	3d	3d	NUM
fnp-3801	129	14	genome	genome	NOUN
fnp-3801	129	15	in	in	ADP
fnp-3801	129	16	the	the	DET
fnp-3801	129	17	brain	brain	NOUN
fnp-3801	129	18	,	,	PUNCT
fnp-3801	129	19	they	they	PRON
fnp-3801	129	20	failed	fail	VERB
fnp-3801	129	21	to	to	PART
fnp-3801	129	22	answer	answer	VERB
fnp-3801	129	23	this	this	DET
fnp-3801	129	24	question	question	NOUN
fnp-3801	129	25	mainly	mainly	ADV
fnp-3801	129	26	due	due	ADP
fnp-3801	129	27	to	to	ADP
fnp-3801	129	28	the	the	DET
fnp-3801	129	29	use	use	NOUN
fnp-3801	129	30	of	of	ADP
fnp-3801	129	31	bulk	bulk	ADJ
fnp-3801	129	32	chromatin	chromatin	NOUN
fnp-3801	129	33	conformation	conformation	NOUN
fnp-3801	129	34	capture	capture	NOUN
fnp-3801	129	35	techniques	technique	NOUN
fnp-3801	129	36	,	,	PUNCT
fnp-3801	129	37	which	which	PRON
fnp-3801	129	38	can	can	AUX
fnp-3801	129	39	only	only	ADV
fnp-3801	129	40	assess	assess	VERB
fnp-3801	129	41	averaged	average	VERB
fnp-3801	129	42	maps	map	NOUN
fnp-3801	129	43	of	of	ADP
fnp-3801	129	44	the	the	DET
fnp-3801	129	45	3d	3d	NUM
fnp-3801	129	46	genome	genome	NOUN
fnp-3801	129	47	.	.	PUNCT
fnp-3801	130	1	this	this	PRON
fnp-3801	130	2	constitutes	constitute	VERB
fnp-3801	130	3	an	an	DET
fnp-3801	130	4	important	important	ADJ
fnp-3801	130	5	limitation	limitation	NOUN
fnp-3801	130	6	in	in	ADP
fnp-3801	130	7	a	a	DET
fnp-3801	130	8	highly	highly	ADV
fnp-3801	130	9	heterogeneous	heterogeneous	ADJ
fnp-3801	130	10	tissue	tissue	NOUN
fnp-3801	130	11	such	such	ADJ
fnp-3801	130	12	as	as	ADP
fnp-3801	130	13	the	the	DET
fnp-3801	130	14	brain	brain	NOUN
fnp-3801	130	15	.	.	PUNCT
fnp-3801	131	1	now	now	ADV
fnp-3801	131	2	,	,	PUNCT
fnp-3801	131	3	tan	tan	PROPN
fnp-3801	131	4	et	et	PROPN
fnp-3801	131	5	al	al	PROPN
fnp-3801	131	6	.	.	PUNCT
fnp-3801	132	1	[	[	X
fnp-3801	132	2	25	25	NUM
fnp-3801	132	3	]	]	PUNCT
fnp-3801	132	4	have	have	AUX
fnp-3801	132	5	overcome	overcome	VERB
fnp-3801	132	6	this	this	DET
fnp-3801	132	7	limitation	limitation	NOUN
fnp-3801	132	8	thanks	thank	NOUN
fnp-3801	132	9	to	to	ADP
fnp-3801	132	10	the	the	DET
fnp-3801	132	11	use	use	NOUN
fnp-3801	132	12	of	of	ADP
fnp-3801	132	13	a	a	DET
fnp-3801	132	14	new	new	ADJ
fnp-3801	132	15	diploid	diploid	ADJ
fnp-3801	132	16	chromatin	chromatin	NOUN
fnp-3801	132	17	conformation	conformation	NOUN
fnp-3801	132	18	capture	capture	NOUN
fnp-3801	132	19	(	(	PUNCT
fnp-3801	132	20	dip	dip	NOUN
fnp-3801	132	21	-	-	PUNCT
fnp-3801	132	22	c	c	NOUN
fnp-3801	132	23	)	)	PUNCT
fnp-3801	132	24	method	method	NOUN
fnp-3801	132	25	[	[	X
fnp-3801	132	26	26	26	NUM
fnp-3801	132	27	]	]	X
fnp-3801	132	28	,	,	PUNCT
fnp-3801	132	29	a	a	DET
fnp-3801	132	30	chromatin	chromatin	NOUN
fnp-3801	132	31	conformation	conformation	NOUN
fnp-3801	132	32	capture	capture	NOUN
fnp-3801	132	33	method	method	NOUN
fnp-3801	132	34	that	that	PRON
fnp-3801	132	35	allows	allow	VERB
fnp-3801	132	36	to	to	PART
fnp-3801	132	37	distinguish	distinguish	VERB
fnp-3801	132	38	between	between	ADP
fnp-3801	132	39	the	the	DET
fnp-3801	132	40	two	two	NUM
fnp-3801	132	41	haplotypes	haplotype	NOUN
fnp-3801	132	42	of	of	ADP
fnp-3801	132	43	each	each	DET
fnp-3801	132	44	chromosome	chromosome	NOUN
fnp-3801	132	45	,	,	PUNCT
fnp-3801	132	46	which	which	PRON
fnp-3801	132	47	allowed	allow	VERB
fnp-3801	132	48	them	they	PRON
fnp-3801	132	49	to	to	PART
fnp-3801	132	50	create	create	VERB
fnp-3801	132	51	a	a	DET
fnp-3801	132	52	3d	3d	NUM
fnp-3801	132	53	genome	genome	NOUN
fnp-3801	132	54	atlas	atlas	PROPN
fnp-3801	132	55	of	of	ADP
fnp-3801	132	56	the	the	DET
fnp-3801	132	57	developing	develop	VERB
fnp-3801	132	58	mouse	mouse	NOUN
fnp-3801	132	59	forebrain	forebrain	NOUN
fnp-3801	132	60	,	,	PUNCT
fnp-3801	132	61	including	include	VERB
fnp-3801	132	62	~2,000	~2,000	NUM
fnp-3801	132	63	single	single	ADJ
fnp-3801	132	64	-	-	PUNCT
fnp-3801	132	65	cell	cell	NOUN
fnp-3801	132	66	contact	contact	NOUN
fnp-3801	132	67	maps	map	NOUN
fnp-3801	132	68	and	and	CCONJ
fnp-3801	132	69	~800	~800	NUM
fnp-3801	132	70	3d	3d	NUM
fnp-3801	132	71	structures	structure	NOUN
fnp-3801	132	72	from	from	ADP
fnp-3801	132	73	two	two	NUM
fnp-3801	132	74	brain	brain	NOUN
fnp-3801	132	75	regions	region	NOUN
fnp-3801	132	76	and	and	CCONJ
fnp-3801	132	77	6	6	NUM
fnp-3801	132	78	time	time	NOUN
fnp-3801	132	79	points	point	NOUN
fnp-3801	132	80	.	.	PUNCT
fnp-3801	133	1	in	in	ADP
fnp-3801	133	2	parallel	parallel	NOUN
fnp-3801	133	3	,	,	PUNCT
fnp-3801	133	4	they	they	PRON
fnp-3801	133	5	also	also	ADV
fnp-3801	133	6	produced	produce	VERB
fnp-3801	133	7	a	a	DET
fnp-3801	133	8	single	single	ADJ
fnp-3801	133	9	-	-	PUNCT
fnp-3801	133	10	cell	cell	NOUN
fnp-3801	133	11	transcriptomic	transcriptomic	ADJ
fnp-3801	133	12	atlas	atlas	PROPN
fnp-3801	133	13	to	to	PART
fnp-3801	133	14	shed	shed	VERB
fnp-3801	133	15	light	light	NOUN
fnp-3801	133	16	on	on	ADP
fnp-3801	133	17	the	the	DET
fnp-3801	133	18	“	"	PUNCT
fnp-3801	133	19	structure	structure	NOUN
fnp-3801	133	20	-	-	PUNCT
fnp-3801	133	21	function	function	NOUN
fnp-3801	133	22	”	"	PUNCT
fnp-3801	133	23	relationship	relationship	NOUN
fnp-3801	133	24	question	question	NOUN
fnp-3801	133	25	during	during	ADP
fnp-3801	133	26	neurodevelopment	neurodevelopment	NOUN
fnp-3801	133	27	.	.	PUNCT
fnp-3801	134	1	importantly	importantly	ADV
fnp-3801	134	2	,	,	PUNCT
fnp-3801	134	3	this	this	DET
fnp-3801	134	4	approach	approach	NOUN
fnp-3801	134	5	revealed	reveal	VERB
fnp-3801	134	6	a	a	DET
fnp-3801	134	7	major	major	ADJ
fnp-3801	134	8	post	post	ADJ
fnp-3801	134	9	-	-	ADJ
fnp-3801	134	10	natal	natal	ADJ
fnp-3801	134	11	transcriptomic	transcriptomic	ADJ
fnp-3801	134	12	and	and	CCONJ
fnp-3801	134	13	3d	3d	NUM
fnp-3801	134	14	structure	structure	NOUN
fnp-3801	134	15	reorganization	reorganization	NOUN
fnp-3801	134	16	.	.	PUNCT
fnp-3801	135	1	in	in	ADP
fnp-3801	135	2	other	other	ADJ
fnp-3801	135	3	words	word	NOUN
fnp-3801	135	4	,	,	PUNCT
fnp-3801	135	5	the	the	DET
fnp-3801	135	6	gene	gene	NOUN
fnp-3801	135	7	expression	expression	NOUN
fnp-3801	135	8	and	and	CCONJ
fnp-3801	135	9	chromatin	chromatin	NOUN
fnp-3801	135	10	architecture	architecture	NOUN
fnp-3801	135	11	profiles	profile	NOUN
fnp-3801	135	12	of	of	ADP
fnp-3801	135	13	postmitotic	postmitotic	ADJ
fnp-3801	135	14	neurons	neuron	NOUN
fnp-3801	135	15	continue	continue	VERB
fnp-3801	135	16	to	to	PART
fnp-3801	135	17	mature	mature	VERB
fnp-3801	135	18	during	during	ADP
fnp-3801	135	19	postnatal	postnatal	ADJ
fnp-3801	135	20	development	development	NOUN
fnp-3801	135	21	.	.	PUNCT
fnp-3801	136	1	at	at	ADP
fnp-3801	136	2	the	the	DET
fnp-3801	136	3	3d	3d	NUM
fnp-3801	136	4	genome	genome	NOUN
fnp-3801	136	5	architecture	architecture	NOUN
fnp-3801	136	6	level	level	NOUN
fnp-3801	136	7	,	,	PUNCT
fnp-3801	136	8	the	the	DET
fnp-3801	136	9	radial	radial	ADJ
fnp-3801	136	10	positioning	positioning	NOUN
fnp-3801	136	11	(	(	PUNCT
fnp-3801	136	12	preference	preference	NOUN
fnp-3801	136	13	for	for	ADP
fnp-3801	136	14	the	the	DET
fnp-3801	136	15	nuclear	nuclear	ADJ
fnp-3801	136	16	periphery	periphery	NOUN
fnp-3801	136	17	or	or	CCONJ
fnp-3801	136	18	nuclear	nuclear	ADJ
fnp-3801	136	19	core	core	NOUN
fnp-3801	136	20	)	)	PUNCT
fnp-3801	136	21	of	of	ADP
fnp-3801	136	22	genes	gene	NOUN
fnp-3801	136	23	was	be	AUX
fnp-3801	136	24	the	the	DET
fnp-3801	136	25	most	most	ADV
fnp-3801	136	26	prominent	prominent	ADJ
fnp-3801	136	27	difference	difference	NOUN
fnp-3801	136	28	between	between	ADP
fnp-3801	136	29	neonatal	neonatal	ADJ
fnp-3801	136	30	and	and	CCONJ
fnp-3801	136	31	adult	adult	NOUN
fnp-3801	136	32	neurons	neuron	NOUN
fnp-3801	136	33	.	.	PUNCT
fnp-3801	137	1	a	a	DET
fnp-3801	137	2	similar	similar	ADJ
fnp-3801	137	3	phenomenon	phenomenon	NOUN
fnp-3801	137	4	was	be	AUX
fnp-3801	137	5	previously	previously	ADV
fnp-3801	137	6	thought	think	VERB
fnp-3801	137	7	to	to	PART
fnp-3801	137	8	be	be	AUX
fnp-3801	137	9	unique	unique	ADJ
fnp-3801	137	10	for	for	ADP
fnp-3801	137	11	certain	certain	ADJ
fnp-3801	137	12	gene	gene	NOUN
fnp-3801	137	13	clusters	cluster	NOUN
fnp-3801	137	14	,	,	PUNCT
fnp-3801	137	15	such	such	ADJ
fnp-3801	137	16	as	as	ADP
fnp-3801	137	17	olfactory	olfactory	ADJ
fnp-3801	137	18	receptors	receptor	NOUN
fnp-3801	137	19	(	(	PUNCT
fnp-3801	137	20	or	or	CCONJ
fnp-3801	137	21	)	)	PUNCT
fnp-3801	137	22	,	,	PUNCT
fnp-3801	137	23	in	in	ADP
fnp-3801	137	24	olfactory	olfactory	ADJ
fnp-3801	137	25	receptor	receptor	NOUN
fnp-3801	137	26	neurons	neuron	NOUN
fnp-3801	137	27	[	[	X
fnp-3801	137	28	27	27	NUM
fnp-3801	137	29	]	]	PUNCT
fnp-3801	137	30	development	development	NOUN
fnp-3801	137	31	.	.	PUNCT
fnp-3801	138	1	importantly	importantly	ADV
fnp-3801	138	2	,	,	PUNCT
fnp-3801	138	3	during	during	ADP
fnp-3801	138	4	developmental	developmental	ADJ
fnp-3801	138	5	stages	stage	NOUN
fnp-3801	138	6	,	,	PUNCT
fnp-3801	138	7	ors	or	NOUN
fnp-3801	138	8	genes	gene	NOUN
fnp-3801	138	9	move	move	VERB
fnp-3801	138	10	to	to	ADP
fnp-3801	138	11	the	the	DET
fnp-3801	138	12	nuclear	nuclear	ADJ
fnp-3801	138	13	interior	interior	NOUN
fnp-3801	138	14	,	,	PUNCT
fnp-3801	138	15	detaching	detach	VERB
fnp-3801	138	16	from	from	ADP
fnp-3801	138	17	the	the	DET
fnp-3801	138	18	nuclear	nuclear	ADJ
fnp-3801	138	19	laminin	laminin	NOUN
fnp-3801	138	20	,	,	PUNCT
fnp-3801	138	21	thereby	thereby	ADV
fnp-3801	138	22	allowing	allow	VERB
fnp-3801	138	23	their	their	PRON
fnp-3801	138	24	activation	activation	NOUN
fnp-3801	138	25	,	,	PUNCT
fnp-3801	138	26	to	to	PART
fnp-3801	138	27	ensure	ensure	VERB
fnp-3801	138	28	that	that	SCONJ
fnp-3801	138	29	each	each	DET
fnp-3801	138	30	olfactory	olfactory	ADJ
fnp-3801	138	31	receptor	receptor	NOUN
fnp-3801	138	32	neuron	neuron	NOUN
fnp-3801	138	33	expresses	express	VERB
fnp-3801	138	34	one	one	NUM
fnp-3801	138	35	,	,	PUNCT
fnp-3801	138	36	and	and	CCONJ
fnp-3801	138	37	only	only	ADV
fnp-3801	138	38	one	one	NUM
fnp-3801	138	39	,	,	PUNCT
fnp-3801	138	40	or	or	CCONJ
fnp-3801	138	41	,	,	PUNCT
fnp-3801	138	42	a	a	DET
fnp-3801	138	43	phenomenon	phenomenon	NOUN
fnp-3801	138	44	called	call	VERB
fnp-3801	138	45	the	the	DET
fnp-3801	138	46	“	"	PUNCT
fnp-3801	138	47	one	one	NUM
fnp-3801	138	48	neuron	neuron	NOUN
fnp-3801	138	49	-	-	PUNCT
fnp-3801	138	50	one	one	NUM
fnp-3801	138	51	receptor	receptor	NOUN
fnp-3801	138	52	expression	expression	NOUN
fnp-3801	138	53	”	"	PUNCT
fnp-3801	139	1	[	[	X
fnp-3801	139	2	27	27	NUM
fnp-3801	139	3	]	]	PUNCT
fnp-3801	139	4	.	.	PUNCT
fnp-3801	140	1	these	these	DET
fnp-3801	140	2	results	result	NOUN
fnp-3801	140	3	,	,	PUNCT
fnp-3801	140	4	however	however	ADV
fnp-3801	140	5	,	,	PUNCT
fnp-3801	140	6	show	show	VERB
fnp-3801	140	7	that	that	SCONJ
fnp-3801	140	8	this	this	DET
fnp-3801	140	9	behavior	behavior	NOUN
fnp-3801	140	10	might	might	AUX
fnp-3801	140	11	represent	represent	VERB
fnp-3801	140	12	a	a	DET
fnp-3801	140	13	generalizable	generalizable	ADJ
fnp-3801	140	14	principle	principle	NOUN
fnp-3801	140	15	of	of	ADP
fnp-3801	140	16	neuron	neuron	PROPN
fnp-3801	140	17	development	development	NOUN
fnp-3801	140	18	not	not	PART
fnp-3801	140	19	restricted	restrict	VERB
fnp-3801	140	20	to	to	PART
fnp-3801	140	21	olfactory	olfactory	ADJ
fnp-3801	140	22	receptor	receptor	NOUN
fnp-3801	140	23	neurons	neuron	NOUN
fnp-3801	140	24	.	.	PUNCT
fnp-3801	141	1	strikingly	strikingly	ADV
fnp-3801	141	2	,	,	PUNCT
fnp-3801	141	3	tan	tan	PROPN
fnp-3801	141	4	et	et	PROPN
fnp-3801	141	5	al	al	PROPN
fnp-3801	141	6	.	.	PROPN
fnp-3801	141	7	also	also	ADV
fnp-3801	141	8	showed	show	VERB
fnp-3801	141	9	that	that	SCONJ
fnp-3801	141	10	these	these	DET
fnp-3801	141	11	transformations	transformation	NOUN
fnp-3801	141	12	of	of	ADP
fnp-3801	141	13	the	the	DET
fnp-3801	141	14	3d	3d	NUM
fnp-3801	141	15	genome	genome	NOUN
fnp-3801	141	16	are	be	AUX
fnp-3801	141	17	independent	independent	ADJ
fnp-3801	141	18	of	of	ADP
fnp-3801	141	19	sensory	sensory	ADJ
fnp-3801	141	20	experience	experience	NOUN
fnp-3801	141	21	,	,	PUNCT
fnp-3801	141	22	suggesting	suggest	VERB
fnp-3801	141	23	that	that	SCONJ
fnp-3801	141	24	the	the	DET
fnp-3801	141	25	3d	3d	PROPN
fnp-3801	141	26	transformation	transformation	NOUN
fnp-3801	141	27	is	be	AUX
fnp-3801	141	28	genetically	genetically	ADV
fnp-3801	141	29	predetermined	predetermine	VERB
fnp-3801	141	30	.	.	PUNCT
fnp-3801	142	1	altogether	altogether	ADV
fnp-3801	142	2	,	,	PUNCT
fnp-3801	142	3	these	these	DET
fnp-3801	142	4	results	result	NOUN
fnp-3801	142	5	provide	provide	VERB
fnp-3801	142	6	new	new	ADJ
fnp-3801	142	7	tools	tool	NOUN
fnp-3801	142	8	and	and	CCONJ
fnp-3801	142	9	a	a	DET
fnp-3801	142	10	conceptual	conceptual	ADJ
fnp-3801	142	11	framework	framework	NOUN
fnp-3801	142	12	to	to	PART
fnp-3801	142	13	shed	shed	VERB
fnp-3801	142	14	light	light	NOUN
fnp-3801	142	15	on	on	ADP
fnp-3801	142	16	the	the	DET
fnp-3801	142	17	molecular	molecular	ADJ
fnp-3801	142	18	mechanisms	mechanism	NOUN
fnp-3801	142	19	governing	govern	VERB
fnp-3801	142	20	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	142	21	processes	process	NOUN
fnp-3801	142	22	at	at	ADP
fnp-3801	142	23	an	an	DET
fnp-3801	142	24	unprecedented	unprecedented	ADJ
fnp-3801	142	25	resolution	resolution	NOUN
fnp-3801	142	26	.	.	PUNCT
fnp-3801	143	1	new	new	ADJ
fnp-3801	143	2	cellular	cellular	ADJ
fnp-3801	143	3	mechanisms	mechanism	NOUN
fnp-3801	143	4	and	and	CCONJ
fnp-3801	143	5	new	new	ADJ
fnp-3801	143	6	tools	tool	NOUN
fnp-3801	143	7	to	to	PART
fnp-3801	143	8	establish	establish	VERB
fnp-3801	143	9	causality	causality	NOUN
fnp-3801	143	10	in	in	ADP
fnp-3801	143	11	asd	asd	PROPN
fnp-3801	143	12	throughout	throughout	ADP
fnp-3801	143	13	the	the	DET
fnp-3801	143	14	last	last	ADJ
fnp-3801	143	15	years	year	NOUN
fnp-3801	143	16	,	,	PUNCT
fnp-3801	143	17	advances	advance	NOUN
fnp-3801	143	18	in	in	ADP
fnp-3801	143	19	the	the	DET
fnp-3801	143	20	field	field	NOUN
fnp-3801	143	21	of	of	ADP
fnp-3801	143	22	genetics	genetic	NOUN
fnp-3801	143	23	have	have	AUX
fnp-3801	143	24	led	lead	VERB
fnp-3801	143	25	to	to	ADP
fnp-3801	143	26	the	the	DET
fnp-3801	143	27	discovery	discovery	NOUN
fnp-3801	143	28	of	of	ADP
fnp-3801	143	29	hundreds	hundred	NOUN
fnp-3801	143	30	of	of	ADP
fnp-3801	143	31	genes	gene	NOUN
fnp-3801	143	32	that	that	PRON
fnp-3801	143	33	contribute	contribute	VERB
fnp-3801	143	34	to	to	ADP
fnp-3801	143	35	serious	serious	ADJ
fnp-3801	143	36	deficits	deficit	NOUN
fnp-3801	143	37	in	in	ADP
fnp-3801	143	38	communication	communication	NOUN
fnp-3801	143	39	,	,	PUNCT
fnp-3801	143	40	social	social	ADJ
fnp-3801	143	41	cognition	cognition	NOUN
fnp-3801	143	42	,	,	PUNCT
fnp-3801	143	43	and	and	CCONJ
fnp-3801	143	44	behavior	behavior	NOUN
fnp-3801	143	45	of	of	ADP
fnp-3801	143	46	autism	autism	NOUN
fnp-3801	143	47	spectrum	spectrum	NOUN
fnp-3801	143	48	disorder	disorder	NOUN
fnp-3801	143	49	(	(	PUNCT
fnp-3801	143	50	asd	asd	NOUN
fnp-3801	143	51	)	)	PUNCT
fnp-3801	143	52	.	.	PUNCT
fnp-3801	144	1	however	however	ADV
fnp-3801	144	2	,	,	PUNCT
fnp-3801	144	3	these	these	DET
fnp-3801	144	4	genes	gene	NOUN
fnp-3801	144	5	only	only	ADV
fnp-3801	144	6	account	account	VERB
fnp-3801	144	7	for	for	ADP
fnp-3801	144	8	10–20	10–20	NUM
fnp-3801	144	9	%	%	NOUN
fnp-3801	144	10	of	of	ADP
fnp-3801	144	11	cases	case	NOUN
fnp-3801	144	12	,	,	PUNCT
fnp-3801	144	13	and	and	CCONJ
fnp-3801	144	14	similar	similar	ADJ
fnp-3801	144	15	pathogenic	pathogenic	ADJ
fnp-3801	144	16	variants	variant	NOUN
fnp-3801	144	17	may	may	AUX
fnp-3801	144	18	lead	lead	VERB
fnp-3801	144	19	to	to	ADP
fnp-3801	144	20	very	very	ADV
fnp-3801	144	21	different	different	ADJ
fnp-3801	144	22	levels	level	NOUN
fnp-3801	144	23	of	of	ADP
fnp-3801	144	24	affectation	affectation	NOUN
fnp-3801	144	25	.	.	PUNCT
fnp-3801	145	1	in	in	ADP
fnp-3801	145	2	fact	fact	NOUN
fnp-3801	145	3	,	,	PUNCT
fnp-3801	145	4	understanding	understand	VERB
fnp-3801	145	5	causal	causal	ADJ
fnp-3801	145	6	relationships	relationship	NOUN
fnp-3801	145	7	between	between	ADP
fnp-3801	145	8	genes	gene	NOUN
fnp-3801	145	9	and	and	CCONJ
fnp-3801	145	10	phenotypes	phenotype	NOUN
fnp-3801	145	11	remains	remain	VERB
fnp-3801	145	12	a	a	DET
fnp-3801	145	13	challenge	challenge	NOUN
fnp-3801	145	14	.	.	PUNCT
fnp-3801	146	1	recent	recent	ADJ
fnp-3801	146	2	evidence	evidence	NOUN
fnp-3801	146	3	suggests	suggest	VERB
fnp-3801	146	4	that	that	SCONJ
fnp-3801	146	5	dysfunction	dysfunction	NOUN
fnp-3801	146	6	of	of	ADP
fnp-3801	146	7	rho	rho	ADJ
fnp-3801	146	8	family	family	NOUN
fnp-3801	146	9	guanosine	guanosine	NOUN
fnp-3801	146	10	triphosphatases	triphosphatase	NOUN
fnp-3801	146	11	(	(	PUNCT
fnp-3801	146	12	rho	rho	NOUN
fnp-3801	146	13	-	-	PUNCT
fnp-3801	146	14	gtpases	gtpase	NOUN
fnp-3801	146	15	)	)	PUNCT
fnp-3801	146	16	contributes	contribute	VERB
fnp-3801	146	17	substantially	substantially	ADV
fnp-3801	146	18	to	to	ADP
fnp-3801	146	19	the	the	DET
fnp-3801	146	20	pathogenesis	pathogenesis	NOUN
fnp-3801	146	21	of	of	ADP
fnp-3801	146	22	ndds	ndd	NOUN
fnp-3801	147	1	[	[	X
fnp-3801	147	2	28	28	NUM
fnp-3801	147	3	,	,	PUNCT
fnp-3801	147	4	29	29	NUM
fnp-3801	147	5	]	]	PUNCT
fnp-3801	147	6	,	,	PUNCT
fnp-3801	147	7	and	and	CCONJ
fnp-3801	147	8	as	as	ADV
fnp-3801	147	9	many	many	ADJ
fnp-3801	147	10	as	as	ADP
fnp-3801	147	11	20	20	NUM
fnp-3801	147	12	genes	gene	NOUN
fnp-3801	147	13	encoding	encode	VERB
fnp-3801	147	14	rho	rho	ADJ
fnp-3801	147	15	gtpase	gtpase	NOUN
fnp-3801	147	16	regulators	regulator	NOUN
fnp-3801	147	17	and	and	CCONJ
fnp-3801	147	18	effectors	effector	NOUN
fnp-3801	147	19	are	be	AUX
fnp-3801	147	20	listed	list	VERB
fnp-3801	147	21	as	as	ADP
fnp-3801	147	22	asd	asd	NOUN
fnp-3801	147	23	risk	risk	NOUN
fnp-3801	147	24	genes	gene	NOUN
fnp-3801	147	25	[	[	X
fnp-3801	147	26	30	30	NUM
fnp-3801	147	27	,	,	PUNCT
fnp-3801	147	28	31	31	NUM
fnp-3801	147	29	]	]	PUNCT
fnp-3801	147	30	.	.	PUNCT
fnp-3801	148	1	those	those	DET
fnp-3801	148	2	genes	gene	NOUN
fnp-3801	148	3	are	be	AUX
fnp-3801	148	4	promising	promise	VERB
fnp-3801	148	5	candidates	candidate	NOUN
fnp-3801	148	6	to	to	PART
fnp-3801	148	7	explain	explain	VERB
fnp-3801	148	8	asd	asd	PROPN
fnp-3801	148	9	neuropathology	neuropathology	NOUN
fnp-3801	148	10	.	.	PUNCT
fnp-3801	149	1	rho	rho	ADJ
fnp-3801	149	2	gtpase	gtpase	NOUN
fnp-3801	149	3	signaling	signal	VERB
fnp-3801	149	4	is	be	AUX
fnp-3801	149	5	essential	essential	ADJ
fnp-3801	149	6	for	for	ADP
fnp-3801	149	7	cellular	cellular	ADJ
fnp-3801	149	8	signaling	signaling	NOUN
fnp-3801	149	9	and	and	CCONJ
fnp-3801	149	10	cytoskeleton	cytoskeleton	NOUN
fnp-3801	149	11	dynamics	dynamic	NOUN
fnp-3801	149	12	[	[	X
fnp-3801	149	13	32	32	NUM
fnp-3801	149	14	,	,	PUNCT
fnp-3801	149	15	33	33	NUM
fnp-3801	149	16	]	]	PUNCT
fnp-3801	149	17	.	.	PUNCT
fnp-3801	150	1	one	one	NUM
fnp-3801	150	2	interesting	interesting	ADJ
fnp-3801	150	3	example	example	NOUN
fnp-3801	150	4	is	be	AUX
fnp-3801	150	5	the	the	DET
fnp-3801	150	6	p21	p21	NOUN
fnp-3801	150	7	-	-	PUNCT
fnp-3801	150	8	activated	activate	VERB
fnp-3801	150	9	kinase	kinase	NOUN
fnp-3801	150	10	3	3	NUM
fnp-3801	150	11	(	(	PUNCT
fnp-3801	150	12	pak3	pak3	PROPN
fnp-3801	150	13	)	)	PUNCT
fnp-3801	150	14	,	,	PUNCT
fnp-3801	150	15	which	which	PRON
fnp-3801	150	16	is	be	AUX
fnp-3801	150	17	a	a	DET
fnp-3801	150	18	downstream	downstream	ADJ
fnp-3801	150	19	component	component	NOUN
fnp-3801	150	20	of	of	ADP
fnp-3801	150	21	the	the	DET
fnp-3801	150	22	rho	rho	ADJ
fnp-3801	150	23	-	-	PUNCT
fnp-3801	150	24	gtpase	gtpase	NOUN
fnp-3801	150	25	cascade	cascade	NOUN
fnp-3801	150	26	.	.	PUNCT
fnp-3801	151	1	genetic	genetic	ADJ
fnp-3801	151	2	studies	study	NOUN
fnp-3801	151	3	in	in	ADP
fnp-3801	151	4	humans	human	NOUN
fnp-3801	151	5	revealed	reveal	VERB
fnp-3801	151	6	that	that	SCONJ
fnp-3801	151	7	mutations	mutation	NOUN
fnp-3801	151	8	of	of	ADP
fnp-3801	151	9	pak3	pak3	NOUN
fnp-3801	151	10	are	be	AUX
fnp-3801	151	11	associated	associate	VERB
fnp-3801	151	12	with	with	ADP
fnp-3801	151	13	moderate	moderate	ADJ
fnp-3801	151	14	to	to	ADP
fnp-3801	151	15	severe	severe	ADJ
fnp-3801	151	16	intellectual	intellectual	ADJ
fnp-3801	151	17	disability	disability	NOUN
fnp-3801	151	18	(	(	PUNCT
fnp-3801	151	19	i	i	NOUN
fnp-3801	151	20	d	d	PROPN
fnp-3801	151	21	)	)	PUNCT
fnp-3801	151	22	and	and	CCONJ
fnp-3801	151	23	with	with	ADP
fnp-3801	151	24	synaptic	synaptic	ADJ
fnp-3801	151	25	alterations	alteration	NOUN
fnp-3801	151	26	in	in	ADP
fnp-3801	151	27	post	post	NOUN
fnp-3801	151	28	mortem	mortem	X
fnp-3801	151	29	human	human	ADJ
fnp-3801	151	30	tissues	tissue	NOUN
fnp-3801	151	31	[	[	X
fnp-3801	151	32	34	34	NUM
fnp-3801	151	33	-	-	SYM
fnp-3801	151	34	36	36	NUM
fnp-3801	151	35	]	]	PUNCT
fnp-3801	151	36	.	.	PUNCT
fnp-3801	152	1	animal	animal	NOUN
fnp-3801	152	2	models	model	NOUN
fnp-3801	152	3	with	with	ADP
fnp-3801	152	4	pak3	pak3	NOUN
fnp-3801	152	5	mutations	mutation	NOUN
fnp-3801	152	6	(	(	PUNCT
fnp-3801	152	7	mpak3	mpak3	NOUN
fnp-3801	152	8	)	)	PUNCT
fnp-3801	152	9	also	also	ADV
fnp-3801	152	10	recapitulate	recapitulate	VERB
fnp-3801	152	11	these	these	DET
fnp-3801	152	12	phenotypes	phenotype	NOUN
fnp-3801	152	13	and	and	CCONJ
fnp-3801	152	14	have	have	AUX
fnp-3801	152	15	shown	show	VERB
fnp-3801	152	16	that	that	SCONJ
fnp-3801	152	17	pak3	pak3	NOUN
fnp-3801	152	18	is	be	AUX
fnp-3801	152	19	important	important	ADJ
fnp-3801	152	20	for	for	ADP
fnp-3801	152	21	recognition	recognition	NOUN
fnp-3801	152	22	memory	memory	NOUN
fnp-3801	153	1	[	[	X
fnp-3801	153	2	37	37	NUM
fnp-3801	153	3	,	,	PUNCT
fnp-3801	153	4	38	38	NUM
fnp-3801	153	5	]	]	PUNCT
fnp-3801	153	6	.	.	PUNCT
fnp-3801	154	1	in	in	ADP
fnp-3801	154	2	fact	fact	NOUN
fnp-3801	154	3	,	,	PUNCT
fnp-3801	154	4	pak	pak	NOUN
fnp-3801	154	5	activity	activity	NOUN
fnp-3801	154	6	,	,	PUNCT
fnp-3801	154	7	in	in	ADP
fnp-3801	154	8	combination	combination	NOUN
fnp-3801	154	9	with	with	ADP
fnp-3801	154	10	rac	rac	PROPN
fnp-3801	154	11	(	(	PUNCT
fnp-3801	154	12	a	a	DET
fnp-3801	154	13	rho	rho	ADJ
fnp-3801	154	14	-	-	PUNCT
fnp-3801	154	15	gtpase	gtpase	NOUN
fnp-3801	154	16	)	)	PUNCT
fnp-3801	154	17	,	,	PUNCT
fnp-3801	154	18	has	have	AUX
fnp-3801	154	19	been	be	AUX
fnp-3801	154	20	suggested	suggest	VERB
fnp-3801	154	21	to	to	PART
fnp-3801	154	22	be	be	AUX
fnp-3801	154	23	responsible	responsible	ADJ
fnp-3801	154	24	for	for	ADP
fnp-3801	154	25	the	the	DET
fnp-3801	154	26	autistic	autistic	ADJ
fnp-3801	154	27	cellular	cellular	ADJ
fnp-3801	154	28	and	and	CCONJ
fnp-3801	154	29	clinical	clinical	ADJ
fnp-3801	154	30	phenotypes	phenotype	NOUN
fnp-3801	154	31	in	in	ADP
fnp-3801	154	32	mouse	mouse	NOUN
fnp-3801	154	33	models	model	NOUN
fnp-3801	154	34	of	of	ADP
fnp-3801	154	35	asd	asd	NOUN
fnp-3801	154	36	,	,	PUNCT
fnp-3801	154	37	and	and	CCONJ
fnp-3801	154	38	may	may	AUX
fnp-3801	154	39	be	be	AUX
fnp-3801	154	40	related	relate	VERB
fnp-3801	154	41	to	to	ADP
fnp-3801	154	42	synaptic	synaptic	ADJ
fnp-3801	154	43	plasticity	plasticity	NOUN
fnp-3801	154	44	alterations	alteration	NOUN
fnp-3801	154	45	[	[	X
fnp-3801	154	46	39	39	NUM
fnp-3801	154	47	]	]	PUNCT
fnp-3801	154	48	.	.	PUNCT
fnp-3801	155	1	however	however	ADV
fnp-3801	155	2	,	,	PUNCT
fnp-3801	155	3	a	a	DET
fnp-3801	155	4	causal	causal	NOUN
fnp-3801	155	5	link	link	NOUN
fnp-3801	155	6	between	between	ADP
fnp-3801	155	7	these	these	DET
fnp-3801	155	8	mutations	mutation	NOUN
fnp-3801	155	9	and	and	CCONJ
fnp-3801	155	10	autistic	autistic	ADJ
fnp-3801	155	11	phenotypes	phenotype	NOUN
fnp-3801	155	12	has	have	AUX
fnp-3801	155	13	not	not	PART
fnp-3801	155	14	yet	yet	ADV
fnp-3801	155	15	been	be	AUX
fnp-3801	155	16	directly	directly	ADV
fnp-3801	155	17	demonstrated	demonstrate	VERB
fnp-3801	155	18	.	.	PUNCT
fnp-3801	156	1	one	one	NUM
fnp-3801	156	2	possible	possible	ADJ
fnp-3801	156	3	problem	problem	NOUN
fnp-3801	156	4	is	be	AUX
fnp-3801	156	5	the	the	DET
fnp-3801	156	6	lack	lack	NOUN
fnp-3801	156	7	of	of	ADP
fnp-3801	156	8	spatial	spatial	ADJ
fnp-3801	156	9	-	-	PUNCT
fnp-3801	156	10	temporal	temporal	ADJ
fnp-3801	156	11	resolution	resolution	NOUN
fnp-3801	156	12	of	of	ADP
fnp-3801	156	13	the	the	DET
fnp-3801	156	14	investigations	investigation	NOUN
fnp-3801	156	15	.	.	PUNCT
fnp-3801	157	1	for	for	ADP
fnp-3801	157	2	example	example	NOUN
fnp-3801	157	3	,	,	PUNCT
fnp-3801	157	4	a	a	DET
fnp-3801	157	5	gene	gene	NOUN
fnp-3801	157	6	mutation	mutation	NOUN
fnp-3801	157	7	may	may	AUX
fnp-3801	157	8	have	have	VERB
fnp-3801	157	9	specific	specific	ADJ
fnp-3801	157	10	neuropathological	neuropathological	ADJ
fnp-3801	157	11	impact	impact	NOUN
fnp-3801	157	12	on	on	ADP
fnp-3801	157	13	a	a	DET
fnp-3801	157	14	subpopulation	subpopulation	NOUN
fnp-3801	157	15	of	of	ADP
fnp-3801	157	16	cells	cell	NOUN
fnp-3801	157	17	,	,	PUNCT
fnp-3801	157	18	which	which	PRON
fnp-3801	157	19	can	can	AUX
fnp-3801	157	20	not	not	PART
fnp-3801	157	21	be	be	AUX
fnp-3801	157	22	selectively	selectively	ADV
fnp-3801	157	23	targeted	target	VERB
fnp-3801	157	24	.	.	PUNCT
fnp-3801	158	1	this	this	PRON
fnp-3801	158	2	is	be	AUX
fnp-3801	158	3	the	the	DET
fnp-3801	158	4	case	case	NOUN
fnp-3801	158	5	with	with	ADP
fnp-3801	158	6	memories	memory	NOUN
fnp-3801	158	7	,	,	PUNCT
fnp-3801	158	8	which	which	PRON
fnp-3801	158	9	are	be	AUX
fnp-3801	158	10	believed	believe	VERB
fnp-3801	158	11	to	to	PART
fnp-3801	158	12	be	be	AUX
fnp-3801	158	13	stored	store	VERB
fnp-3801	158	14	in	in	ADP
fnp-3801	158	15	a	a	DET
fnp-3801	158	16	subpopulation	subpopulation	NOUN
fnp-3801	158	17	of	of	ADP
fnp-3801	158	18	neurons	neuron	NOUN
fnp-3801	158	19	that	that	PRON
fnp-3801	158	20	get	get	AUX
fnp-3801	158	21	activated	activate	VERB
fnp-3801	158	22	and	and	CCONJ
fnp-3801	158	23	modify	modify	VERB
fnp-3801	158	24	their	their	PRON
fnp-3801	158	25	functional	functional	ADJ
fnp-3801	158	26	properties	property	NOUN
fnp-3801	158	27	during	during	ADP
fnp-3801	158	28	learning	learn	VERB
fnp-3801	158	29	.	.	PUNCT
fnp-3801	159	1	those	those	PRON
fnp-3801	159	2	are	be	AUX
fnp-3801	159	3	called	call	VERB
fnp-3801	159	4	engram	engram	PROPN
fnp-3801	159	5	cells	cell	NOUN
fnp-3801	159	6	[	[	X
fnp-3801	159	7	40	40	NUM
fnp-3801	159	8	,	,	PUNCT
fnp-3801	159	9	41	41	NUM
fnp-3801	159	10	]	]	PUNCT
fnp-3801	159	11	,	,	PUNCT
fnp-3801	159	12	and	and	CCONJ
fnp-3801	159	13	might	might	AUX
fnp-3801	159	14	be	be	AUX
fnp-3801	159	15	specifically	specifically	ADV
fnp-3801	159	16	affected	affect	VERB
fnp-3801	159	17	by	by	ADP
fnp-3801	159	18	pak3	pak3	NOUN
fnp-3801	159	19	mutations	mutation	NOUN
fnp-3801	159	20	.	.	PUNCT
fnp-3801	160	1	for	for	ADP
fnp-3801	160	2	this	this	DET
fnp-3801	160	3	reason	reason	NOUN
fnp-3801	160	4	,	,	PUNCT
fnp-3801	160	5	zhou	zhou	PROPN
fnp-3801	160	6	et	et	PROPN
fnp-3801	160	7	al	al	PROPN
fnp-3801	160	8	.	.	PROPN
fnp-3801	160	9	designed	design	VERB
fnp-3801	160	10	a	a	DET
fnp-3801	160	11	tetracycline	tetracycline	NOUN
fnp-3801	160	12	-	-	PUNCT
fnp-3801	160	13	inducible	inducible	ADJ
fnp-3801	160	14	system	system	NOUN
fnp-3801	160	15	(	(	PUNCT
fnp-3801	160	16	tta	tta	PROPN
fnp-3801	160	17	/	/	SYM
fnp-3801	160	18	teto	teto	PROPN
fnp-3801	160	19	)	)	PUNCT
fnp-3801	160	20	under	under	ADP
fnp-3801	160	21	the	the	DET
fnp-3801	160	22	control	control	NOUN
fnp-3801	160	23	of	of	ADP
fnp-3801	160	24	cfos	cfos	PROPN
fnp-3801	160	25	,	,	PUNCT
fnp-3801	160	26	to	to	PART
fnp-3801	160	27	express	express	VERB
fnp-3801	160	28	a	a	DET
fnp-3801	160	29	mutant	mutant	ADJ
fnp-3801	160	30	pak3	pak3	NOUN
fnp-3801	160	31	form	form	NOUN
fnp-3801	160	32	tagged	tag	VERB
fnp-3801	160	33	with	with	ADP
fnp-3801	160	34	green	green	ADJ
fnp-3801	160	35	fluorescent	fluorescent	ADJ
fnp-3801	160	36	protein	protein	NOUN
fnp-3801	160	37	(	(	PUNCT
fnp-3801	160	38	mpak3	mpak3	NOUN
fnp-3801	160	39	-	-	PUNCT
fnp-3801	160	40	gfp	gfp	NOUN
fnp-3801	160	41	)	)	PUNCT
fnp-3801	160	42	specifically	specifically	ADV
fnp-3801	160	43	in	in	ADP
fnp-3801	160	44	neurons	neuron	NOUN
fnp-3801	160	45	that	that	PRON
fnp-3801	160	46	were	be	AUX
fnp-3801	160	47	activated	activate	VERB
fnp-3801	160	48	during	during	ADP
fnp-3801	160	49	social	social	ADJ
fnp-3801	160	50	interaction	interaction	NOUN
fnp-3801	161	1	[	[	X
fnp-3801	161	2	42	42	NUM
fnp-3801	161	3	]	]	PUNCT
fnp-3801	161	4	.	.	PUNCT
fnp-3801	162	1	cfos	cfos	PROPN
fnp-3801	162	2	is	be	AUX
fnp-3801	162	3	an	an	DET
fnp-3801	162	4	immediate	immediate	ADJ
fnp-3801	162	5	early	early	ADJ
fnp-3801	162	6	gene	gene	NOUN
fnp-3801	162	7	associated	associate	VERB
fnp-3801	162	8	with	with	ADP
fnp-3801	162	9	neuronal	neuronal	ADJ
fnp-3801	162	10	activity	activity	NOUN
fnp-3801	162	11	and	and	CCONJ
fnp-3801	162	12	synaptic	synaptic	ADJ
fnp-3801	162	13	plasticity	plasticity	NOUN
fnp-3801	162	14	and	and	CCONJ
fnp-3801	162	15	is	be	AUX
fnp-3801	162	16	often	often	ADV
fnp-3801	162	17	used	use	VERB
fnp-3801	162	18	to	to	PART
fnp-3801	162	19	identify	identify	VERB
fnp-3801	162	20	engram	engram	PROPN
fnp-3801	162	21	cells	cell	NOUN
fnp-3801	162	22	[	[	X
fnp-3801	162	23	40	40	NUM
fnp-3801	162	24	,	,	PUNCT
fnp-3801	162	25	41	41	NUM
fnp-3801	162	26	,	,	PUNCT
fnp-3801	162	27	43	43	NUM
fnp-3801	162	28	]	]	PUNCT
fnp-3801	162	29	.	.	PUNCT
fnp-3801	163	1	the	the	DET
fnp-3801	163	2	authors	author	NOUN
fnp-3801	163	3	showed	show	VERB
fnp-3801	163	4	that	that	SCONJ
fnp-3801	163	5	disrupting	disrupt	VERB
fnp-3801	163	6	pak3	pak3	NOUN
fnp-3801	163	7	signaling	signal	VERB
fnp-3801	163	8	by	by	ADP
fnp-3801	163	9	the	the	DET
fnp-3801	163	10	expression	expression	NOUN
fnp-3801	163	11	of	of	ADP
fnp-3801	163	12	mpak3	mpak3	NOUN
fnp-3801	163	13	in	in	ADP
fnp-3801	163	14	cfos	cfos	NOUN
fnp-3801	163	15	-	-	PUNCT
fnp-3801	163	16	expressing	express	VERB
fnp-3801	163	17	neurons	neuron	NOUN
fnp-3801	163	18	during	during	ADP
fnp-3801	163	19	social	social	ADJ
fnp-3801	163	20	interactions	interaction	NOUN
fnp-3801	163	21	in	in	ADP
fnp-3801	163	22	fact	fact	NOUN
fnp-3801	163	23	was	be	AUX
fnp-3801	163	24	sufficient	sufficient	ADJ
fnp-3801	163	25	to	to	PART
fnp-3801	163	26	impair	impair	VERB
fnp-3801	163	27	social	social	ADJ
fnp-3801	163	28	memory	memory	NOUN
fnp-3801	163	29	.	.	PUNCT
fnp-3801	164	1	contrarily	contrarily	ADV
fnp-3801	164	2	,	,	PUNCT
fnp-3801	164	3	rescuing	rescue	VERB
fnp-3801	164	4	mpak3	mpak3	NOUN
fnp-3801	164	5	levels	level	NOUN
fnp-3801	164	6	in	in	ADP
fnp-3801	164	7	the	the	DET
fnp-3801	164	8	same	same	ADJ
fnp-3801	164	9	animals	animal	NOUN
fnp-3801	164	10	restored	restore	VERB
fnp-3801	164	11	social	social	ADJ
fnp-3801	164	12	memory	memory	NOUN
fnp-3801	164	13	deficits	deficit	NOUN
fnp-3801	164	14	.	.	PUNCT
fnp-3801	165	1	the	the	DET
fnp-3801	165	2	fact	fact	NOUN
fnp-3801	165	3	that	that	SCONJ
fnp-3801	165	4	pak3	pak3	NOUN
fnp-3801	165	5	disruption	disruption	NOUN
fnp-3801	165	6	in	in	ADP
fnp-3801	165	7	just	just	ADV
fnp-3801	165	8	a	a	DET
fnp-3801	165	9	subset	subset	NOUN
fnp-3801	165	10	of	of	ADP
fnp-3801	165	11	cfos	cfos	PROPN
fnp-3801	165	12	positive	positive	ADJ
fnp-3801	165	13	cells	cell	NOUN
fnp-3801	165	14	is	be	AUX
fnp-3801	165	15	sufficient	sufficient	ADJ
fnp-3801	165	16	to	to	PART
fnp-3801	165	17	produce	produce	VERB
fnp-3801	165	18	social	social	ADJ
fnp-3801	165	19	memory	memory	NOUN
fnp-3801	165	20	impairment	impairment	NOUN
fnp-3801	165	21	underscores	underscore	VERB
fnp-3801	165	22	the	the	DET
fnp-3801	165	23	critical	critical	ADJ
fnp-3801	165	24	importance	importance	NOUN
fnp-3801	165	25	of	of	ADP
fnp-3801	165	26	increasing	increase	VERB
fnp-3801	165	27	the	the	DET
fnp-3801	165	28	resolution	resolution	NOUN
fnp-3801	165	29	of	of	ADP
fnp-3801	165	30	the	the	DET
fnp-3801	165	31	techniques	technique	NOUN
fnp-3801	165	32	we	we	PRON
fnp-3801	165	33	use	use	VERB
fnp-3801	165	34	.	.	PUNCT
fnp-3801	166	1	in	in	ADP
fnp-3801	166	2	this	this	DET
fnp-3801	166	3	regard	regard	NOUN
fnp-3801	166	4	,	,	PUNCT
fnp-3801	166	5	an	an	DET
fnp-3801	166	6	increasing	increase	VERB
fnp-3801	166	7	number	number	NOUN
fnp-3801	166	8	of	of	ADP
fnp-3801	166	9	studies	study	NOUN
fnp-3801	166	10	are	be	AUX
fnp-3801	166	11	using	use	VERB
fnp-3801	166	12	single	single	ADJ
fnp-3801	166	13	-	-	PUNCT
fnp-3801	166	14	cell	cell	NOUN
fnp-3801	166	15	omics	omic	NOUN
fnp-3801	166	16	for	for	ADP
fnp-3801	166	17	resolving	resolve	VERB
fnp-3801	166	18	the	the	DET
fnp-3801	166	19	cell	cell	NOUN
fnp-3801	166	20	-	-	PUNCT
fnp-3801	166	21	specific	specific	ADJ
fnp-3801	166	22	impact	impact	NOUN
fnp-3801	166	23	of	of	ADP
fnp-3801	166	24	specific	specific	ADJ
fnp-3801	166	25	mutations	mutation	NOUN
fnp-3801	166	26	,	,	PUNCT
fnp-3801	166	27	and	and	CCONJ
fnp-3801	166	28	single	single	ADJ
fnp-3801	166	29	-	-	PUNCT
fnp-3801	166	30	cell	cell	NOUN
fnp-3801	166	31	rna	rna	NOUN
fnp-3801	166	32	seq	seq	NOUN
fnp-3801	166	33	data	datum	NOUN
fnp-3801	166	34	are	be	AUX
fnp-3801	166	35	available	available	ADJ
fnp-3801	166	36	from	from	ADP
fnp-3801	166	37	post	post	NOUN
fnp-3801	166	38	mortem	mortem	X
fnp-3801	166	39	neurotypical	neurotypical	ADJ
fnp-3801	166	40	human	human	ADJ
fnp-3801	166	41	brain	brain	NOUN
fnp-3801	166	42	regions	region	NOUN
fnp-3801	166	43	.	.	PUNCT
fnp-3801	167	1	even	even	ADV
fnp-3801	167	2	though	though	SCONJ
fnp-3801	167	3	the	the	DET
fnp-3801	167	4	mechanisms	mechanism	NOUN
fnp-3801	167	5	by	by	ADP
fnp-3801	167	6	which	which	PRON
fnp-3801	167	7	mpak3	mpak3	NOUN
fnp-3801	167	8	was	be	AUX
fnp-3801	167	9	altering	alter	VERB
fnp-3801	167	10	social	social	ADJ
fnp-3801	167	11	memory	memory	NOUN
fnp-3801	167	12	engrams	engram	NOUN
fnp-3801	167	13	were	be	AUX
fnp-3801	167	14	not	not	PART
fnp-3801	167	15	covered	cover	VERB
fnp-3801	167	16	in	in	ADP
fnp-3801	167	17	this	this	DET
fnp-3801	167	18	study	study	NOUN
fnp-3801	167	19	,	,	PUNCT
fnp-3801	167	20	to	to	ADP
fnp-3801	167	21	date	date	NOUN
fnp-3801	167	22	this	this	PRON
fnp-3801	167	23	is	be	AUX
fnp-3801	167	24	the	the	DET
fnp-3801	167	25	first	first	ADJ
fnp-3801	167	26	experimental	experimental	ADJ
fnp-3801	167	27	demonstration	demonstration	NOUN
fnp-3801	167	28	that	that	PRON
fnp-3801	167	29	establishes	establish	VERB
fnp-3801	167	30	the	the	DET
fnp-3801	167	31	necessity	necessity	NOUN
fnp-3801	167	32	of	of	ADP
fnp-3801	167	33	pak	pak	NOUN
fnp-3801	167	34	-	-	PUNCT
fnp-3801	167	35	dependent	dependent	ADJ
fnp-3801	167	36	molecular	molecular	ADJ
fnp-3801	167	37	changes	change	NOUN
fnp-3801	167	38	in	in	ADP
fnp-3801	167	39	engram	engram	PROPN
fnp-3801	167	40	cells	cell	NOUN
fnp-3801	167	41	underlying	underlie	VERB
fnp-3801	167	42	social	social	ADJ
fnp-3801	167	43	memory	memory	NOUN
fnp-3801	167	44	pathology	pathology	NOUN
fnp-3801	167	45	.	.	PUNCT
fnp-3801	168	1	certainly	certainly	ADV
fnp-3801	168	2	,	,	PUNCT
fnp-3801	168	3	this	this	DET
fnp-3801	168	4	cell	cell	NOUN
fnp-3801	168	5	-	-	PUNCT
fnp-3801	168	6	specific	specific	ADJ
fnp-3801	168	7	system	system	NOUN
fnp-3801	168	8	can	can	AUX
fnp-3801	168	9	be	be	AUX
fnp-3801	168	10	used	use	VERB
fnp-3801	168	11	to	to	PART
fnp-3801	168	12	establish	establish	VERB
fnp-3801	168	13	molecular	molecular	ADJ
fnp-3801	168	14	causality	causality	NOUN
fnp-3801	168	15	of	of	ADP
fnp-3801	168	16	memory	memory	NOUN
fnp-3801	168	17	deficits	deficit	NOUN
fnp-3801	168	18	in	in	ADP
fnp-3801	168	19	different	different	ADJ
fnp-3801	168	20	mouse	mouse	NOUN
fnp-3801	168	21	models	model	NOUN
fnp-3801	168	22	of	of	ADP
fnp-3801	168	23	ndds	ndd	NOUN
fnp-3801	168	24	given	give	VERB
fnp-3801	168	25	the	the	DET
fnp-3801	168	26	ability	ability	NOUN
fnp-3801	168	27	to	to	ADP
fnp-3801	168	28	fine	fine	ADJ
fnp-3801	168	29	-	-	PUNCT
fnp-3801	168	30	tune	tune	NOUN
fnp-3801	168	31	the	the	DET
fnp-3801	168	32	expression	expression	NOUN
fnp-3801	168	33	of	of	ADP
fnp-3801	168	34	particular	particular	ADJ
fnp-3801	168	35	genes	gene	NOUN
fnp-3801	168	36	that	that	PRON
fnp-3801	168	37	could	could	AUX
fnp-3801	168	38	be	be	AUX
fnp-3801	168	39	potentially	potentially	ADV
fnp-3801	168	40	implicated	implicate	VERB
fnp-3801	168	41	in	in	ADP
fnp-3801	168	42	the	the	DET
fnp-3801	168	43	neuropathology	neuropathology	NOUN
fnp-3801	168	44	of	of	ADP
fnp-3801	168	45	these	these	DET
fnp-3801	168	46	disorders	disorder	NOUN
fnp-3801	168	47	in	in	ADP
fnp-3801	168	48	an	an	DET
fnp-3801	168	49	inducible	inducible	ADJ
fnp-3801	168	50	manner	manner	NOUN
fnp-3801	168	51	.	.	PUNCT
fnp-3801	169	1	increasing	increase	VERB
fnp-3801	169	2	the	the	DET
fnp-3801	169	3	resolution	resolution	NOUN
fnp-3801	169	4	and	and	CCONJ
fnp-3801	169	5	selectivity	selectivity	NOUN
fnp-3801	169	6	of	of	ADP
fnp-3801	169	7	our	our	PRON
fnp-3801	169	8	experimental	experimental	ADJ
fnp-3801	169	9	approaches	approach	NOUN
fnp-3801	169	10	will	will	AUX
fnp-3801	169	11	certainly	certainly	ADV
fnp-3801	169	12	uncover	uncover	VERB
fnp-3801	169	13	new	new	ADJ
fnp-3801	169	14	neuropathological	neuropathological	ADJ
fnp-3801	169	15	mechanisms	mechanism	NOUN
fnp-3801	169	16	and	and	CCONJ
fnp-3801	169	17	possibly	possibly	ADV
fnp-3801	169	18	help	help	VERB
fnp-3801	169	19	to	to	PART
fnp-3801	169	20	understand	understand	VERB
fnp-3801	169	21	the	the	DET
fnp-3801	169	22	actual	actual	ADJ
fnp-3801	169	23	contribution	contribution	NOUN
fnp-3801	169	24	of	of	ADP
fnp-3801	169	25	risk	risk	NOUN
fnp-3801	169	26	genes	gene	NOUN
fnp-3801	169	27	to	to	ADP
fnp-3801	169	28	the	the	DET
fnp-3801	169	29	pathogenesis	pathogenesis	NOUN
fnp-3801	169	30	of	of	ADP
fnp-3801	169	31	autism	autism	NOUN
fnp-3801	169	32	and	and	CCONJ
fnp-3801	169	33	other	other	ADJ
fnp-3801	169	34	ndds	ndd	NOUN
fnp-3801	169	35	.	.	PUNCT
fnp-3801	170	1	new	new	ADJ
fnp-3801	170	2	mechanisms	mechanism	NOUN
fnp-3801	170	3	in	in	ADP
fnp-3801	170	4	asd	asd	PROPN
fnp-3801	170	5	pathology	pathology	PROPN
fnp-3801	170	6	:	:	PUNCT
fnp-3801	170	7	astrocytes	astrocyte	NOUN
fnp-3801	170	8	,	,	PUNCT
fnp-3801	170	9	atp	atp	PROPN
fnp-3801	170	10	and	and	CCONJ
fnp-3801	170	11	gabaergic	gabaergic	NOUN
fnp-3801	170	12	signaling	signal	VERB
fnp-3801	170	13	the	the	DET
fnp-3801	170	14	research	research	NOUN
fnp-3801	170	15	in	in	ADP
fnp-3801	170	16	asd	asd	PROPN
fnp-3801	170	17	has	have	AUX
fnp-3801	170	18	traditionally	traditionally	ADV
fnp-3801	170	19	focused	focus	VERB
fnp-3801	170	20	on	on	ADP
fnp-3801	170	21	neuronal	neuronal	ADJ
fnp-3801	170	22	dysfunction	dysfunction	NOUN
fnp-3801	170	23	,	,	PUNCT
fnp-3801	170	24	as	as	SCONJ
fnp-3801	170	25	many	many	ADJ
fnp-3801	170	26	asd	asd	NOUN
fnp-3801	170	27	genes	gene	NOUN
fnp-3801	170	28	encode	encode	VERB
fnp-3801	170	29	for	for	ADP
fnp-3801	170	30	proteins	protein	NOUN
fnp-3801	170	31	that	that	PRON
fnp-3801	170	32	have	have	VERB
fnp-3801	170	33	a	a	DET
fnp-3801	170	34	role	role	NOUN
fnp-3801	170	35	in	in	ADP
fnp-3801	170	36	synaptic	synaptic	ADJ
fnp-3801	170	37	function	function	NOUN
fnp-3801	170	38	,	,	PUNCT
fnp-3801	170	39	thus	thus	ADV
fnp-3801	170	40	making	make	VERB
fnp-3801	170	41	the	the	DET
fnp-3801	170	42	views	view	NOUN
fnp-3801	170	43	of	of	ADP
fnp-3801	170	44	the	the	DET
fnp-3801	170	45	pathological	pathological	ADJ
fnp-3801	170	46	features	feature	NOUN
fnp-3801	170	47	of	of	ADP
fnp-3801	170	48	asd	asd	NOUN
fnp-3801	170	49	mainly	mainly	ADV
fnp-3801	170	50	“	"	PUNCT
fnp-3801	170	51	neurocentric	neurocentric	ADJ
fnp-3801	170	52	”	"	PUNCT
fnp-3801	170	53	.	.	PUNCT
fnp-3801	171	1	however	however	ADV
fnp-3801	171	2	,	,	PUNCT
fnp-3801	171	3	selectively	selectively	ADV
fnp-3801	171	4	focusing	focus	VERB
fnp-3801	171	5	on	on	ADP
fnp-3801	171	6	neuronal	neuronal	ADJ
fnp-3801	171	7	mechanisms	mechanism	NOUN
fnp-3801	171	8	has	have	AUX
fnp-3801	171	9	proven	prove	VERB
fnp-3801	171	10	to	to	PART
fnp-3801	171	11	be	be	AUX
fnp-3801	171	12	limited	limit	VERB
fnp-3801	171	13	,	,	PUNCT
fnp-3801	171	14	and	and	CCONJ
fnp-3801	171	15	thus	thus	ADV
fnp-3801	171	16	,	,	PUNCT
fnp-3801	171	17	alternative	alternative	ADJ
fnp-3801	171	18	biological	biological	ADJ
fnp-3801	171	19	analyses	analysis	NOUN
fnp-3801	171	20	may	may	AUX
fnp-3801	171	21	help	help	VERB
fnp-3801	171	22	to	to	PART
fnp-3801	171	23	reveal	reveal	VERB
fnp-3801	171	24	previously	previously	ADV
fnp-3801	171	25	unknown	unknown	ADJ
fnp-3801	171	26	cellular	cellular	ADJ
fnp-3801	171	27	and	and	CCONJ
fnp-3801	171	28	molecular	molecular	ADJ
fnp-3801	171	29	mechanisms	mechanism	NOUN
fnp-3801	171	30	.	.	PUNCT
fnp-3801	172	1	astrocytes	astrocyte	NOUN
fnp-3801	172	2	are	be	AUX
fnp-3801	172	3	newly	newly	ADV
fnp-3801	172	4	identified	identify	VERB
fnp-3801	172	5	players	player	NOUN
fnp-3801	172	6	in	in	ADP
fnp-3801	172	7	several	several	ADJ
fnp-3801	172	8	brain	brain	NOUN
fnp-3801	172	9	pathologies	pathology	NOUN
fnp-3801	172	10	,	,	PUNCT
fnp-3801	172	11	and	and	CCONJ
fnp-3801	172	12	could	could	AUX
fnp-3801	172	13	play	play	VERB
fnp-3801	172	14	an	an	DET
fnp-3801	172	15	important	important	ADJ
fnp-3801	172	16	role	role	NOUN
fnp-3801	172	17	in	in	ADP
fnp-3801	172	18	asd	asd	PROPN
fnp-3801	172	19	.	.	PUNCT
fnp-3801	173	1	in	in	ADP
fnp-3801	173	2	fact	fact	NOUN
fnp-3801	173	3	,	,	PUNCT
fnp-3801	173	4	rna	rna	NOUN
fnp-3801	173	5	sequencing	sequencing	NOUN
fnp-3801	173	6	revealed	reveal	VERB
fnp-3801	173	7	a	a	DET
fnp-3801	173	8	close	close	ADJ
fnp-3801	173	9	association	association	NOUN
fnp-3801	173	10	between	between	ADP
fnp-3801	173	11	asd	asd	PROPN
fnp-3801	173	12	and	and	CCONJ
fnp-3801	173	13	the	the	DET
fnp-3801	173	14	genes	gene	NOUN
fnp-3801	173	15	related	relate	VERB
fnp-3801	173	16	to	to	ADP
fnp-3801	173	17	glial	glial	ADJ
fnp-3801	173	18	cell	cell	NOUN
fnp-3801	173	19	activation	activation	NOUN
fnp-3801	173	20	,	,	PUNCT
fnp-3801	173	21	immune	immune	ADJ
fnp-3801	173	22	and	and	CCONJ
fnp-3801	173	23	inflammatory	inflammatory	ADJ
fnp-3801	173	24	categories	category	NOUN
fnp-3801	173	25	[	[	X
fnp-3801	173	26	44	44	NUM
fnp-3801	173	27	]	]	PUNCT
fnp-3801	173	28	.	.	PUNCT
fnp-3801	174	1	studies	study	NOUN
fnp-3801	174	2	in	in	ADP
fnp-3801	174	3	post	post	X
fnp-3801	174	4	mortem	mortem	X
fnp-3801	174	5	brain	brain	NOUN
fnp-3801	174	6	tissue	tissue	NOUN
fnp-3801	174	7	from	from	ADP
fnp-3801	174	8	donors	donor	NOUN
fnp-3801	174	9	affected	affect	VERB
fnp-3801	174	10	by	by	ADP
fnp-3801	174	11	asd	asd	PROPN
fnp-3801	174	12	have	have	AUX
fnp-3801	174	13	shown	show	VERB
fnp-3801	174	14	alterations	alteration	NOUN
fnp-3801	174	15	in	in	ADP
fnp-3801	174	16	the	the	DET
fnp-3801	174	17	expression	expression	NOUN
fnp-3801	174	18	of	of	ADP
fnp-3801	174	19	astrocyte	astrocyte	NOUN
fnp-3801	174	20	markers	marker	NOUN
fnp-3801	174	21	,	,	PUNCT
fnp-3801	174	22	and	and	CCONJ
fnp-3801	174	23	ipscs	ipsc	NOUN
fnp-3801	174	24	derived	derive	VERB
fnp-3801	174	25	from	from	ADP
fnp-3801	174	26	asd	asd	PROPN
fnp-3801	174	27	patients	patient	NOUN
fnp-3801	174	28	present	present	ADJ
fnp-3801	174	29	alterations	alteration	NOUN
fnp-3801	174	30	in	in	ADP
fnp-3801	174	31	astrocytic	astrocytic	ADJ
fnp-3801	174	32	development	development	NOUN
fnp-3801	175	1	[	[	X
fnp-3801	175	2	45	45	NUM
fnp-3801	175	3	,	,	PUNCT
fnp-3801	175	4	46	46	NUM
fnp-3801	175	5	]	]	PUNCT
fnp-3801	175	6	.	.	PUNCT
fnp-3801	176	1	one	one	NUM
fnp-3801	176	2	recent	recent	ADJ
fnp-3801	176	3	preprint	preprint	NOUN
fnp-3801	176	4	shows	show	VERB
fnp-3801	176	5	that	that	SCONJ
fnp-3801	176	6	astrocytes	astrocyte	NOUN
fnp-3801	176	7	from	from	ADP
fnp-3801	176	8	asd	asd	PROPN
fnp-3801	176	9	patients	patient	NOUN
fnp-3801	176	10	cause	cause	VERB
fnp-3801	176	11	autistic	autistic	ADJ
fnp-3801	176	12	phenotypes	phenotype	NOUN
fnp-3801	176	13	when	when	SCONJ
fnp-3801	176	14	engrafted	engraft	VERB
fnp-3801	176	15	in	in	ADP
fnp-3801	176	16	mouse	mouse	NOUN
fnp-3801	176	17	pups	pup	NOUN
fnp-3801	176	18	,	,	PUNCT
fnp-3801	176	19	establishing	establish	VERB
fnp-3801	176	20	an	an	DET
fnp-3801	176	21	important	important	ADJ
fnp-3801	176	22	milestone	milestone	NOUN
fnp-3801	176	23	in	in	ADP
fnp-3801	176	24	the	the	DET
fnp-3801	176	25	asd	asd	NOUN
fnp-3801	176	26	field	field	NOUN
fnp-3801	177	1	[	[	X
fnp-3801	177	2	47	47	NUM
fnp-3801	177	3	]	]	PUNCT
fnp-3801	177	4	.	.	PUNCT
fnp-3801	178	1	however	however	ADV
fnp-3801	178	2	,	,	PUNCT
fnp-3801	178	3	whether	whether	SCONJ
fnp-3801	178	4	astrocytes	astrocyte	NOUN
fnp-3801	178	5	alterations	alteration	NOUN
fnp-3801	178	6	are	be	AUX
fnp-3801	178	7	the	the	DET
fnp-3801	178	8	cause	cause	NOUN
fnp-3801	178	9	or	or	CCONJ
fnp-3801	178	10	the	the	DET
fnp-3801	178	11	consequence	consequence	NOUN
fnp-3801	178	12	of	of	ADP
fnp-3801	178	13	asd	asd	NOUN
fnp-3801	178	14	and	and	CCONJ
fnp-3801	178	15	how	how	SCONJ
fnp-3801	178	16	this	this	DET
fnp-3801	178	17	glial	glial	ADJ
fnp-3801	178	18	cell	cell	NOUN
fnp-3801	178	19	type	type	NOUN
fnp-3801	178	20	contributes	contribute	VERB
fnp-3801	178	21	to	to	ADP
fnp-3801	178	22	asd	asd	PROPN
fnp-3801	178	23	pathology	pathology	NOUN
fnp-3801	178	24	remains	remain	VERB
fnp-3801	178	25	unclear	unclear	ADJ
fnp-3801	178	26	.	.	PUNCT
fnp-3801	179	1	interestingly	interestingly	ADV
fnp-3801	179	2	,	,	PUNCT
fnp-3801	179	3	de	de	ADP
fnp-3801	179	4	novo	novo	NOUN
fnp-3801	179	5	mutations	mutation	NOUN
fnp-3801	179	6	in	in	ADP
fnp-3801	179	7	type	type	NOUN
fnp-3801	179	8	2	2	NUM
fnp-3801	179	9	inositol	inositol	NOUN
fnp-3801	179	10	1,4,5	1,4,5	NUM
fnp-3801	179	11	-	-	PUNCT
fnp-3801	179	12	trisphosphate	trisphosphate	NOUN
fnp-3801	179	13	receptors	receptor	NOUN
fnp-3801	179	14	(	(	PUNCT
fnp-3801	179	15	ip3r2	ip3r2	NOUN
fnp-3801	179	16	)	)	PUNCT
fnp-3801	179	17	gene	gene	NOUN
fnp-3801	179	18	have	have	AUX
fnp-3801	179	19	been	be	AUX
fnp-3801	179	20	identified	identify	VERB
fnp-3801	179	21	in	in	ADP
fnp-3801	179	22	asd	asd	PROPN
fnp-3801	179	23	patients	patient	NOUN
fnp-3801	179	24	[	[	X
fnp-3801	179	25	48	48	NUM
fnp-3801	179	26	]	]	PUNCT
fnp-3801	179	27	.	.	PUNCT
fnp-3801	180	1	this	this	DET
fnp-3801	180	2	receptor	receptor	NOUN
fnp-3801	180	3	mediates	mediate	VERB
fnp-3801	180	4	the	the	DET
fnp-3801	180	5	activation	activation	NOUN
fnp-3801	180	6	of	of	ADP
fnp-3801	180	7	astrocytes	astrocyte	NOUN
fnp-3801	180	8	by	by	ADP
fnp-3801	180	9	increasing	increase	VERB
fnp-3801	180	10	cytoplasmic	cytoplasmic	ADJ
fnp-3801	180	11	calcium	calcium	NOUN
fnp-3801	180	12	signaling	signal	VERB
fnp-3801	180	13	[	[	X
fnp-3801	180	14	49	49	NUM
fnp-3801	180	15	]	]	PUNCT
fnp-3801	180	16	,	,	PUNCT
fnp-3801	180	17	and	and	CCONJ
fnp-3801	180	18	previous	previous	ADJ
fnp-3801	180	19	studies	study	NOUN
fnp-3801	180	20	in	in	ADP
fnp-3801	180	21	ip3r2	ip3r2	PROPN
fnp-3801	180	22	knockout	knockout	NOUN
fnp-3801	180	23	(	(	PUNCT
fnp-3801	180	24	ip3r2	ip3r2	PROPN
fnp-3801	180	25	ko	ko	NOUN
fnp-3801	180	26	)	)	PUNCT
fnp-3801	180	27	mice	mouse	NOUN
fnp-3801	180	28	showed	show	VERB
fnp-3801	180	29	selective	selective	ADJ
fnp-3801	180	30	dysfunction	dysfunction	NOUN
fnp-3801	180	31	of	of	ADP
fnp-3801	180	32	astrocytes	astrocyte	NOUN
fnp-3801	180	33	but	but	CCONJ
fnp-3801	180	34	not	not	PART
fnp-3801	180	35	neurons	neuron	NOUN
fnp-3801	180	36	leading	lead	VERB
fnp-3801	180	37	to	to	ADP
fnp-3801	180	38	social	social	ADJ
fnp-3801	180	39	behavior	behavior	NOUN
fnp-3801	180	40	impairment	impairment	ADJ
fnp-3801	180	41	,	,	PUNCT
fnp-3801	180	42	as	as	SCONJ
fnp-3801	180	43	revealed	reveal	VERB
fnp-3801	180	44	by	by	ADP
fnp-3801	180	45	increased	increase	VERB
fnp-3801	180	46	repetitive	repetitive	ADJ
fnp-3801	180	47	behaviors	behavior	NOUN
fnp-3801	180	48	and	and	CCONJ
fnp-3801	180	49	impaired	impaired	ADJ
fnp-3801	180	50	social	social	ADJ
fnp-3801	180	51	approach	approach	NOUN
fnp-3801	180	52	[	[	X
fnp-3801	180	53	50	50	NUM
fnp-3801	180	54	]	]	PUNCT
fnp-3801	180	55	.	.	PUNCT
fnp-3801	181	1	wang	wang	PROPN
fnp-3801	181	2	et	et	PROPN
fnp-3801	181	3	al	al	PROPN
fnp-3801	181	4	.	.	PUNCT
fnp-3801	182	1	[	[	X
fnp-3801	182	2	51	51	NUM
fnp-3801	182	3	]	]	PUNCT
fnp-3801	182	4	now	now	ADV
fnp-3801	182	5	show	show	VERB
fnp-3801	182	6	that	that	PRON
fnp-3801	182	7	astrocyte	astrocyte	NOUN
fnp-3801	182	8	calcium	calcium	NOUN
fnp-3801	182	9	signaling	signal	VERB
fnp-3801	182	10	dysfunction	dysfunction	NOUN
fnp-3801	182	11	can	can	AUX
fnp-3801	182	12	result	result	VERB
fnp-3801	182	13	in	in	ADP
fnp-3801	182	14	asd	asd	PROPN
fnp-3801	182	15	-	-	PUNCT
fnp-3801	182	16	like	like	ADJ
fnp-3801	182	17	behavior	behavior	NOUN
fnp-3801	182	18	in	in	ADP
fnp-3801	182	19	mice	mouse	NOUN
fnp-3801	182	20	.	.	PUNCT
fnp-3801	183	1	the	the	DET
fnp-3801	183	2	authors	author	NOUN
fnp-3801	183	3	generated	generate	VERB
fnp-3801	183	4	a	a	DET
fnp-3801	183	5	conditional	conditional	ADJ
fnp-3801	183	6	knockout	knockout	NOUN
fnp-3801	183	7	(	(	PUNCT
fnp-3801	183	8	cko	cko	PROPN
fnp-3801	183	9	)	)	PUNCT
fnp-3801	183	10	mouse	mouse	NOUN
fnp-3801	183	11	for	for	ADP
fnp-3801	183	12	ip3r2	ip3r2	NOUN
fnp-3801	183	13	using	use	VERB
fnp-3801	183	14	an	an	DET
fnp-3801	183	15	astrocyte	astrocyte	NOUN
fnp-3801	183	16	-	-	PUNCT
fnp-3801	183	17	specific	specific	ADJ
fnp-3801	183	18	promoter	promoter	NOUN
fnp-3801	183	19	,	,	PUNCT
fnp-3801	183	20	aldh1l1	aldh1l1	NOUN
fnp-3801	183	21	,	,	PUNCT
fnp-3801	183	22	that	that	PRON
fnp-3801	183	23	induces	induce	VERB
fnp-3801	183	24	the	the	DET
fnp-3801	183	25	ip3r2	ip3r2	PROPN
fnp-3801	183	26	knockout	knockout	NOUN
fnp-3801	183	27	during	during	ADP
fnp-3801	183	28	adulthood	adulthood	NOUN
fnp-3801	183	29	.	.	PUNCT
fnp-3801	184	1	this	this	DET
fnp-3801	184	2	astrocyte	astrocyte	NOUN
fnp-3801	184	3	specific	specific	ADJ
fnp-3801	184	4	ip3r2	ip3r2	PROPN
fnp-3801	184	5	ko	ko	NOUN
fnp-3801	184	6	in	in	ADP
fnp-3801	184	7	adult	adult	NOUN
fnp-3801	184	8	mice	mouse	NOUN
fnp-3801	184	9	was	be	AUX
fnp-3801	184	10	sufficient	sufficient	ADJ
fnp-3801	184	11	to	to	PART
fnp-3801	184	12	produce	produce	VERB
fnp-3801	184	13	autism	autism	NOUN
fnp-3801	184	14	-	-	PUNCT
fnp-3801	184	15	related	relate	VERB
fnp-3801	184	16	behaviors	behavior	NOUN
fnp-3801	184	17	,	,	PUNCT
fnp-3801	184	18	suggesting	suggest	VERB
fnp-3801	184	19	that	that	SCONJ
fnp-3801	184	20	these	these	DET
fnp-3801	184	21	phenotypes	phenotype	NOUN
fnp-3801	184	22	are	be	AUX
fnp-3801	184	23	not	not	PART
fnp-3801	184	24	just	just	ADV
fnp-3801	184	25	a	a	DET
fnp-3801	184	26	consequence	consequence	NOUN
fnp-3801	184	27	of	of	ADP
fnp-3801	184	28	altered	altered	ADJ
fnp-3801	184	29	neurodevelopment	neurodevelopment	NOUN
fnp-3801	184	30	.	.	PUNCT
fnp-3801	185	1	to	to	PART
fnp-3801	185	2	further	far	ADV
fnp-3801	185	3	investigate	investigate	VERB
fnp-3801	185	4	the	the	DET
fnp-3801	185	5	mechanism	mechanism	NOUN
fnp-3801	185	6	underlying	underlie	VERB
fnp-3801	185	7	social	social	ADJ
fnp-3801	185	8	behavior	behavior	NOUN
fnp-3801	185	9	alterations	alteration	NOUN
fnp-3801	185	10	and	and	CCONJ
fnp-3801	185	11	astrocyte	astrocyte	NOUN
fnp-3801	185	12	dysfunction	dysfunction	NOUN
fnp-3801	185	13	in	in	ADP
fnp-3801	185	14	ip3r2	ip3r2	NOUN
fnp-3801	185	15	mutant	mutant	ADJ
fnp-3801	185	16	mice	mouse	NOUN
fnp-3801	185	17	,	,	PUNCT
fnp-3801	185	18	they	they	PRON
fnp-3801	185	19	analyzed	analyze	VERB
fnp-3801	185	20	the	the	DET
fnp-3801	185	21	levels	level	NOUN
fnp-3801	185	22	of	of	ADP
fnp-3801	185	23	different	different	ADJ
fnp-3801	185	24	gliotransmitters	gliotransmitter	NOUN
fnp-3801	185	25	.	.	PUNCT
fnp-3801	186	1	they	they	PRON
fnp-3801	186	2	found	find	VERB
fnp-3801	186	3	a	a	DET
fnp-3801	186	4	strong	strong	ADJ
fnp-3801	186	5	reduction	reduction	NOUN
fnp-3801	186	6	in	in	ADP
fnp-3801	186	7	atp	atp	PROPN
fnp-3801	186	8	levels	level	NOUN
fnp-3801	186	9	,	,	PUNCT
fnp-3801	186	10	a	a	DET
fnp-3801	186	11	known	know	VERB
fnp-3801	186	12	gliotransmitter	gliotransmitter	NOUN
fnp-3801	186	13	,	,	PUNCT
fnp-3801	186	14	in	in	ADP
fnp-3801	186	15	ipr32	ipr32	PROPN
fnp-3801	186	16	cko	cko	PROPN
fnp-3801	186	17	mice	mouse	NOUN
fnp-3801	186	18	.	.	PUNCT
fnp-3801	187	1	this	this	DET
fnp-3801	187	2	reduction	reduction	NOUN
fnp-3801	187	3	in	in	ADP
fnp-3801	187	4	atp	atp	NOUN
fnp-3801	187	5	concentrations	concentration	NOUN
fnp-3801	187	6	was	be	AUX
fnp-3801	187	7	only	only	ADV
fnp-3801	187	8	found	find	VERB
fnp-3801	187	9	in	in	ADP
fnp-3801	187	10	astrocytes	astrocyte	NOUN
fnp-3801	187	11	but	but	CCONJ
fnp-3801	187	12	not	not	PART
fnp-3801	187	13	in	in	ADP
fnp-3801	187	14	neurons	neuron	NOUN
fnp-3801	187	15	isolated	isolate	VERB
fnp-3801	187	16	from	from	ADP
fnp-3801	187	17	ipr32	ipr32	PROPN
fnp-3801	187	18	cko	cko	PROPN
fnp-3801	187	19	mice	mouse	NOUN
fnp-3801	187	20	,	,	PUNCT
fnp-3801	187	21	indicating	indicate	VERB
fnp-3801	187	22	astrocytes	astrocyte	NOUN
fnp-3801	187	23	-	-	PUNCT
fnp-3801	187	24	specific	specific	ADJ
fnp-3801	187	25	alterations	alteration	NOUN
fnp-3801	187	26	.	.	PUNCT
fnp-3801	188	1	using	use	VERB
fnp-3801	188	2	chemogenetic	chemogenetic	ADJ
fnp-3801	188	3	techniques	technique	NOUN
fnp-3801	188	4	and	and	CCONJ
fnp-3801	188	5	an	an	DET
fnp-3801	188	6	atp	atp	NOUN
fnp-3801	188	7	sensor	sensor	NOUN
fnp-3801	188	8	under	under	ADP
fnp-3801	188	9	an	an	DET
fnp-3801	188	10	astrocytic	astrocytic	ADJ
fnp-3801	188	11	promoter	promoter	NOUN
fnp-3801	188	12	,	,	PUNCT
fnp-3801	188	13	they	they	PRON
fnp-3801	188	14	demonstrated	demonstrate	VERB
fnp-3801	188	15	that	that	SCONJ
fnp-3801	188	16	atp	atp	PROPN
fnp-3801	188	17	release	release	NOUN
fnp-3801	188	18	was	be	AUX
fnp-3801	188	19	significantly	significantly	ADV
fnp-3801	188	20	reduced	reduce	VERB
fnp-3801	188	21	in	in	ADP
fnp-3801	188	22	ip3r2	ip3r2	PROPN
fnp-3801	188	23	cko	cko	NOUN
fnp-3801	188	24	and	and	CCONJ
fnp-3801	188	25	that	that	SCONJ
fnp-3801	188	26	atp	atp	PROPN
fnp-3801	188	27	administration	administration	NOUN
fnp-3801	188	28	led	lead	VERB
fnp-3801	188	29	to	to	ADP
fnp-3801	188	30	a	a	DET
fnp-3801	188	31	total	total	ADJ
fnp-3801	188	32	rescue	rescue	NOUN
fnp-3801	188	33	of	of	ADP
fnp-3801	188	34	social	social	ADJ
fnp-3801	188	35	interaction	interaction	NOUN
fnp-3801	188	36	.	.	PUNCT
fnp-3801	189	1	this	this	PRON
fnp-3801	189	2	indicates	indicate	VERB
fnp-3801	189	3	the	the	DET
fnp-3801	189	4	need	need	NOUN
fnp-3801	189	5	of	of	ADP
fnp-3801	189	6	atp	atp	PROPN
fnp-3801	189	7	release	release	NOUN
fnp-3801	189	8	by	by	ADP
fnp-3801	189	9	astrocytes	astrocyte	NOUN
fnp-3801	189	10	for	for	ADP
fnp-3801	189	11	proper	proper	ADJ
fnp-3801	189	12	social	social	ADJ
fnp-3801	189	13	interaction	interaction	NOUN
fnp-3801	189	14	.	.	PUNCT
fnp-3801	190	1	this	this	DET
fnp-3801	190	2	finding	finding	NOUN
fnp-3801	190	3	establishes	establish	VERB
fnp-3801	190	4	a	a	DET
fnp-3801	190	5	new	new	ADJ
fnp-3801	190	6	pathogenic	pathogenic	ADJ
fnp-3801	190	7	mechanism	mechanism	NOUN
fnp-3801	190	8	:	:	PUNCT
fnp-3801	190	9	lower	low	ADJ
fnp-3801	190	10	release	release	NOUN
fnp-3801	190	11	of	of	ADP
fnp-3801	190	12	atp	atp	PROPN
fnp-3801	190	13	after	after	ADP
fnp-3801	190	14	astrocyte	astrocyte	NOUN
fnp-3801	190	15	activation	activation	NOUN
fnp-3801	190	16	leads	lead	VERB
fnp-3801	190	17	to	to	ADP
fnp-3801	190	18	an	an	DET
fnp-3801	190	19	increase	increase	NOUN
fnp-3801	190	20	of	of	ADP
fnp-3801	190	21	gabaergic	gabaergic	ADJ
fnp-3801	190	22	inhibitory	inhibitory	ADJ
fnp-3801	190	23	activity	activity	NOUN
fnp-3801	190	24	.	.	PUNCT
fnp-3801	191	1	however	however	ADV
fnp-3801	191	2	,	,	PUNCT
fnp-3801	191	3	the	the	DET
fnp-3801	191	4	pathogenetic	pathogenetic	ADJ
fnp-3801	191	5	mechanisms	mechanism	NOUN
fnp-3801	191	6	are	be	AUX
fnp-3801	191	7	certainly	certainly	ADV
fnp-3801	191	8	more	more	ADV
fnp-3801	191	9	complicated	complicated	ADJ
fnp-3801	191	10	,	,	PUNCT
fnp-3801	191	11	as	as	SCONJ
fnp-3801	191	12	shown	show	VERB
fnp-3801	191	13	by	by	ADP
fnp-3801	191	14	other	other	ADJ
fnp-3801	191	15	recent	recent	ADJ
fnp-3801	191	16	studies	study	NOUN
fnp-3801	191	17	reporting	report	VERB
fnp-3801	191	18	that	that	SCONJ
fnp-3801	191	19	astrocyte	astrocyte	NOUN
fnp-3801	191	20	dysfunction	dysfunction	NOUN
fnp-3801	191	21	could	could	AUX
fnp-3801	191	22	lead	lead	VERB
fnp-3801	191	23	to	to	ADP
fnp-3801	191	24	an	an	DET
fnp-3801	191	25	altered	altered	ADJ
fnp-3801	191	26	microglial	microglial	ADJ
fnp-3801	191	27	state	state	NOUN
fnp-3801	191	28	[	[	X
fnp-3801	191	29	52	52	NUM
fnp-3801	191	30	]	]	PUNCT
fnp-3801	191	31	,	,	PUNCT
fnp-3801	191	32	and	and	CCONJ
fnp-3801	191	33	lead	lead	VERB
fnp-3801	191	34	to	to	ADP
fnp-3801	191	35	increased	increase	VERB
fnp-3801	191	36	neuroinflammatory	neuroinflammatory	ADJ
fnp-3801	191	37	processes	process	NOUN
fnp-3801	191	38	.	.	PUNCT
fnp-3801	192	1	in	in	ADP
fnp-3801	192	2	conclusion	conclusion	NOUN
fnp-3801	192	3	,	,	PUNCT
fnp-3801	192	4	astrocyte	astrocyte	NOUN
fnp-3801	192	5	activity	activity	NOUN
fnp-3801	192	6	,	,	PUNCT
fnp-3801	192	7	mediated	mediate	VERB
fnp-3801	192	8	by	by	ADP
fnp-3801	192	9	calcium	calcium	NOUN
fnp-3801	192	10	signaling	signal	VERB
fnp-3801	192	11	pathways	pathway	NOUN
fnp-3801	192	12	,	,	PUNCT
fnp-3801	192	13	plays	play	VERB
fnp-3801	192	14	a	a	DET
fnp-3801	192	15	pivotal	pivotal	ADJ
fnp-3801	192	16	role	role	NOUN
fnp-3801	192	17	in	in	ADP
fnp-3801	192	18	asd	asd	PROPN
fnp-3801	192	19	pathology	pathology	PROPN
fnp-3801	192	20	.	.	PUNCT
fnp-3801	193	1	disentangling	disentangle	VERB
fnp-3801	193	2	the	the	DET
fnp-3801	193	3	role	role	NOUN
fnp-3801	193	4	of	of	ADP
fnp-3801	193	5	repeatome	repeatome	NOUN
fnp-3801	193	6	in	in	ADP
fnp-3801	193	7	asd	asd	PROPN
fnp-3801	193	8	approximately	approximately	ADV
fnp-3801	193	9	half	half	NOUN
fnp-3801	193	10	of	of	ADP
fnp-3801	193	11	the	the	DET
fnp-3801	193	12	human	human	ADJ
fnp-3801	193	13	genome	genome	NOUN
fnp-3801	193	14	consists	consist	VERB
fnp-3801	193	15	of	of	ADP
fnp-3801	193	16	repetitive	repetitive	ADJ
fnp-3801	193	17	dna	dna	NOUN
fnp-3801	193	18	sequences	sequence	NOUN
fnp-3801	193	19	,	,	PUNCT
fnp-3801	193	20	and	and	CCONJ
fnp-3801	193	21	is	be	AUX
fnp-3801	193	22	called	call	VERB
fnp-3801	193	23	the	the	DET
fnp-3801	193	24	repeatome	repeatome	NOUN
fnp-3801	193	25	.	.	PUNCT
fnp-3801	194	1	repetitive	repetitive	ADJ
fnp-3801	194	2	dna	dna	PROPN
fnp-3801	194	3	consists	consist	VERB
fnp-3801	194	4	of	of	ADP
fnp-3801	194	5	more	more	ADJ
fnp-3801	194	6	than	than	ADP
fnp-3801	194	7	one	one	NUM
fnp-3801	194	8	million	million	NUM
fnp-3801	194	9	tandem	tandem	NOUN
fnp-3801	194	10	repeats	repeat	NOUN
fnp-3801	194	11	,	,	PUNCT
fnp-3801	194	12	sections	section	NOUN
fnp-3801	194	13	of	of	ADP
fnp-3801	194	14	dna	dna	PROPN
fnp-3801	194	15	in	in	ADP
fnp-3801	194	16	which	which	PRON
fnp-3801	194	17	a	a	DET
fnp-3801	194	18	sequence	sequence	NOUN
fnp-3801	194	19	is	be	AUX
fnp-3801	194	20	replicated	replicate	VERB
fnp-3801	194	21	many	many	ADJ
fnp-3801	194	22	times	time	NOUN
fnp-3801	194	23	in	in	ADP
fnp-3801	194	24	tandems	tandem	NOUN
fnp-3801	194	25	,	,	PUNCT
fnp-3801	194	26	interspersed	intersperse	VERB
fnp-3801	194	27	repeats	repeat	NOUN
fnp-3801	194	28	and	and	CCONJ
fnp-3801	194	29	copy	copy	VERB
fnp-3801	194	30	number	number	NOUN
fnp-3801	194	31	variants	variant	NOUN
fnp-3801	194	32	,	,	PUNCT
fnp-3801	194	33	which	which	DET
fnp-3801	194	34	biology	biology	NOUN
fnp-3801	194	35	remains	remain	VERB
fnp-3801	194	36	under	under	ADV
fnp-3801	194	37	-	-	PUNCT
fnp-3801	194	38	studied	study	VERB
fnp-3801	194	39	and	and	CCONJ
fnp-3801	194	40	poorly	poorly	ADV
fnp-3801	194	41	annotated	annotate	VERB
fnp-3801	194	42	,	,	PUNCT
fnp-3801	194	43	being	be	AUX
fnp-3801	194	44	considered	consider	VERB
fnp-3801	194	45	as	as	ADP
fnp-3801	194	46	“	"	PUNCT
fnp-3801	194	47	junk	junk	NOUN
fnp-3801	194	48	dna	dna	NOUN
fnp-3801	194	49	”	"	PUNCT
fnp-3801	194	50	compared	compare	VERB
fnp-3801	194	51	to	to	ADP
fnp-3801	194	52	the	the	DET
fnp-3801	194	53	protein	protein	NOUN
fnp-3801	194	54	coding	code	VERB
fnp-3801	194	55	dna	dna	NOUN
fnp-3801	195	1	[	[	X
fnp-3801	195	2	53	53	NUM
fnp-3801	195	3	]	]	PUNCT
fnp-3801	195	4	.	.	PUNCT
fnp-3801	196	1	however	however	ADV
fnp-3801	196	2	,	,	PUNCT
fnp-3801	196	3	more	more	ADJ
fnp-3801	196	4	than	than	ADP
fnp-3801	196	5	50	50	NUM
fnp-3801	196	6	diseases	disease	NOUN
fnp-3801	196	7	such	such	ADJ
fnp-3801	196	8	as	as	ADP
fnp-3801	196	9	huntington	huntington	PROPN
fnp-3801	196	10	disease	disease	PROPN
fnp-3801	196	11	,	,	PUNCT
fnp-3801	196	12	fragile	fragile	ADJ
fnp-3801	196	13	x	x	NOUN
fnp-3801	196	14	,	,	PUNCT
fnp-3801	196	15	various	various	ADJ
fnp-3801	196	16	ataxias	ataxia	NOUN
fnp-3801	196	17	and	and	CCONJ
fnp-3801	196	18	a	a	DET
fnp-3801	196	19	major	major	ADJ
fnp-3801	196	20	subset	subset	NOUN
fnp-3801	196	21	of	of	ADP
fnp-3801	196	22	amyotrophic	amyotrophic	ADJ
fnp-3801	196	23	lateral	lateral	ADJ
fnp-3801	196	24	sclerosis	sclerosis	NOUN
fnp-3801	196	25	and	and	CCONJ
fnp-3801	196	26	frontotemporal	frontotemporal	ADJ
fnp-3801	196	27	dementia	dementia	NOUN
fnp-3801	196	28	cases	case	NOUN
fnp-3801	196	29	are	be	AUX
fnp-3801	196	30	caused	cause	VERB
fnp-3801	196	31	by	by	ADP
fnp-3801	196	32	an	an	DET
fnp-3801	196	33	expansion	expansion	NOUN
fnp-3801	196	34	of	of	ADP
fnp-3801	196	35	a	a	DET
fnp-3801	196	36	tandem	tandem	NOUN
fnp-3801	196	37	-	-	PUNCT
fnp-3801	196	38	repeat	repeat	NOUN
fnp-3801	196	39	sequence	sequence	NOUN
fnp-3801	196	40	(	(	PUNCT
fnp-3801	196	41	trs	trs	PROPN
fnp-3801	196	42	)	)	PUNCT
fnp-3801	196	43	,	,	PUNCT
fnp-3801	196	44	showing	show	VERB
fnp-3801	196	45	the	the	DET
fnp-3801	196	46	importance	importance	NOUN
fnp-3801	196	47	of	of	ADP
fnp-3801	196	48	this	this	DET
fnp-3801	196	49	non	non	ADJ
fnp-3801	196	50	-	-	ADJ
fnp-3801	196	51	coding	coding	ADJ
fnp-3801	196	52	dna	dna	NOUN
fnp-3801	196	53	in	in	ADP
fnp-3801	196	54	some	some	DET
fnp-3801	196	55	pathologies	pathology	NOUN
fnp-3801	196	56	[	[	X
fnp-3801	196	57	54	54	NUM
fnp-3801	196	58	]	]	PUNCT
fnp-3801	196	59	.	.	PUNCT
fnp-3801	197	1	repeat	repeat	NOUN
fnp-3801	197	2	-	-	PUNCT
fnp-3801	197	3	associated	associate	VERB
fnp-3801	197	4	non	non	ADJ
fnp-3801	197	5	-	-	ADJ
fnp-3801	197	6	atg	atg	ADJ
fnp-3801	197	7	translation	translation	NOUN
fnp-3801	197	8	(	(	PUNCT
fnp-3801	197	9	ran	run	VERB
fnp-3801	197	10	translation	translation	NOUN
fnp-3801	197	11	)	)	PUNCT
fnp-3801	197	12	of	of	ADP
fnp-3801	197	13	toxic	toxic	ADJ
fnp-3801	197	14	peptides	peptide	NOUN
fnp-3801	197	15	may	may	AUX
fnp-3801	197	16	contribute	contribute	VERB
fnp-3801	197	17	to	to	ADP
fnp-3801	197	18	the	the	DET
fnp-3801	197	19	pathogenesis	pathogenesis	NOUN
fnp-3801	197	20	of	of	ADP
fnp-3801	197	21	those	those	DET
fnp-3801	197	22	disorders	disorder	NOUN
fnp-3801	197	23	and	and	CCONJ
fnp-3801	197	24	emerging	emerge	VERB
fnp-3801	197	25	evidence	evidence	NOUN
fnp-3801	197	26	suggests	suggest	VERB
fnp-3801	197	27	that	that	SCONJ
fnp-3801	197	28	trs	trs	PROPN
fnp-3801	197	29	can	can	AUX
fnp-3801	197	30	also	also	ADV
fnp-3801	197	31	regulate	regulate	VERB
fnp-3801	197	32	gene	gene	NOUN
fnp-3801	197	33	expression	expression	NOUN
fnp-3801	197	34	in	in	ADP
fnp-3801	197	35	healthy	healthy	ADJ
fnp-3801	197	36	individuals	individual	NOUN
fnp-3801	197	37	[	[	X
fnp-3801	197	38	54	54	NUM
fnp-3801	197	39	]	]	PUNCT
fnp-3801	197	40	.	.	PUNCT
fnp-3801	198	1	nonetheless	nonetheless	ADV
fnp-3801	198	2	,	,	PUNCT
fnp-3801	198	3	the	the	DET
fnp-3801	198	4	role	role	NOUN
fnp-3801	198	5	of	of	ADP
fnp-3801	198	6	trs	trs	PROPN
fnp-3801	198	7	in	in	ADP
fnp-3801	198	8	polygenic	polygenic	ADJ
fnp-3801	198	9	pathologies	pathology	NOUN
fnp-3801	198	10	such	such	ADJ
fnp-3801	198	11	as	as	SCONJ
fnp-3801	198	12	asd	asd	PROPN
fnp-3801	198	13	remains	remain	VERB
fnp-3801	198	14	largely	largely	ADV
fnp-3801	198	15	unexplored	unexplored	ADJ
fnp-3801	198	16	.	.	PUNCT
fnp-3801	199	1	even	even	ADV
fnp-3801	199	2	though	though	SCONJ
fnp-3801	199	3	changes	change	NOUN
fnp-3801	199	4	in	in	ADP
fnp-3801	199	5	the	the	DET
fnp-3801	199	6	number	number	NOUN
fnp-3801	199	7	of	of	ADP
fnp-3801	199	8	copies	copy	NOUN
fnp-3801	199	9	of	of	ADP
fnp-3801	199	10	large	large	ADJ
fnp-3801	199	11	segments	segment	NOUN
fnp-3801	199	12	of	of	ADP
fnp-3801	199	13	dna	dna	PROPN
fnp-3801	199	14	have	have	AUX
fnp-3801	199	15	been	be	AUX
fnp-3801	199	16	implicated	implicate	VERB
fnp-3801	199	17	in	in	ADP
fnp-3801	199	18	asd	asd	PROPN
fnp-3801	199	19	pathology	pathology	NOUN
fnp-3801	199	20	[	[	X
fnp-3801	199	21	55	55	NUM
fnp-3801	199	22	]	]	PUNCT
fnp-3801	199	23	,	,	PUNCT
fnp-3801	199	24	the	the	DET
fnp-3801	199	25	capacity	capacity	NOUN
fnp-3801	199	26	to	to	PART
fnp-3801	199	27	analyze	analyze	VERB
fnp-3801	199	28	alterations	alteration	NOUN
fnp-3801	199	29	in	in	ADP
fnp-3801	199	30	trs	trs	PROPN
fnp-3801	199	31	from	from	ADP
fnp-3801	199	32	a	a	DET
fnp-3801	199	33	genome	genome	NOUN
fnp-3801	199	34	-	-	PUNCT
fnp-3801	199	35	wide	wide	ADJ
fnp-3801	199	36	point	point	NOUN
fnp-3801	199	37	of	of	ADP
fnp-3801	199	38	view	view	NOUN
fnp-3801	199	39	was	be	AUX
fnp-3801	199	40	,	,	PUNCT
fnp-3801	199	41	until	until	SCONJ
fnp-3801	199	42	now	now	ADV
fnp-3801	199	43	,	,	PUNCT
fnp-3801	199	44	unachievable	unachievable	ADJ
fnp-3801	199	45	.	.	PUNCT
fnp-3801	200	1	mitra	mitra	PROPN
fnp-3801	200	2	et	et	PROPN
fnp-3801	200	3	al	al	PROPN
fnp-3801	200	4	.	.	PROPN
fnp-3801	200	5	have	have	AUX
fnp-3801	200	6	now	now	ADV
fnp-3801	200	7	developed	develop	VERB
fnp-3801	200	8	a	a	DET
fnp-3801	200	9	new	new	ADJ
fnp-3801	200	10	bioinformatic	bioinformatic	ADJ
fnp-3801	200	11	tool	tool	NOUN
fnp-3801	200	12	capable	capable	ADJ
fnp-3801	200	13	of	of	ADP
fnp-3801	200	14	analyzing	analyze	VERB
fnp-3801	200	15	trs	trs	PROPN
fnp-3801	200	16	in	in	ADP
fnp-3801	200	17	people	people	NOUN
fnp-3801	200	18	with	with	ADP
fnp-3801	200	19	asd	asd	NOUN
fnp-3801	200	20	and	and	CCONJ
fnp-3801	200	21	their	their	PRON
fnp-3801	200	22	family	family	NOUN
fnp-3801	200	23	members	member	NOUN
fnp-3801	200	24	[	[	X
fnp-3801	200	25	56	56	NUM
fnp-3801	200	26	]	]	PUNCT
fnp-3801	200	27	.	.	PUNCT
fnp-3801	201	1	this	this	DET
fnp-3801	201	2	new	new	ADJ
fnp-3801	201	3	bioinformatic	bioinformatic	ADJ
fnp-3801	201	4	tool	tool	NOUN
fnp-3801	201	5	that	that	PRON
fnp-3801	201	6	the	the	DET
fnp-3801	201	7	authors	author	NOUN
fnp-3801	201	8	named	name	VERB
fnp-3801	201	9	monstr	monstr	NOUN
fnp-3801	201	10	,	,	PUNCT
fnp-3801	201	11	allowed	allow	VERB
fnp-3801	201	12	the	the	DET
fnp-3801	201	13	researchers	researcher	NOUN
fnp-3801	201	14	to	to	PART
fnp-3801	201	15	discover	discover	VERB
fnp-3801	201	16	that	that	SCONJ
fnp-3801	201	17	trs	trs	PROPN
fnp-3801	201	18	expansions	expansion	NOUN
fnp-3801	201	19	are	be	AUX
fnp-3801	201	20	more	more	ADV
fnp-3801	201	21	common	common	ADJ
fnp-3801	201	22	in	in	ADP
fnp-3801	201	23	people	people	NOUN
fnp-3801	201	24	with	with	ADP
fnp-3801	201	25	asd	asd	NOUN
fnp-3801	201	26	than	than	ADP
fnp-3801	201	27	in	in	ADP
fnp-3801	201	28	their	their	PRON
fnp-3801	201	29	unaffected	unaffected	ADJ
fnp-3801	201	30	siblings	sibling	NOUN
fnp-3801	201	31	.	.	PUNCT
fnp-3801	202	1	the	the	DET
fnp-3801	202	2	expansions	expansion	NOUN
fnp-3801	202	3	occurred	occur	VERB
fnp-3801	202	4	in	in	ADP
fnp-3801	202	5	genes	gene	NOUN
fnp-3801	202	6	involved	involve	VERB
fnp-3801	202	7	in	in	ADP
fnp-3801	202	8	brain	brain	NOUN
fnp-3801	202	9	development	development	NOUN
fnp-3801	202	10	such	such	ADJ
fnp-3801	202	11	as	as	ADP
fnp-3801	202	12	foxp1	foxp1	ADJ
fnp-3801	202	13	.	.	PUNCT
fnp-3801	203	1	some	some	DET
fnp-3801	203	2	genes	gene	NOUN
fnp-3801	203	3	previously	previously	ADV
fnp-3801	203	4	associated	associate	VERB
fnp-3801	203	5	with	with	ADP
fnp-3801	203	6	asd	asd	NOUN
fnp-3801	203	7	,	,	PUNCT
fnp-3801	203	8	e.g.	e.g.	ADV
fnp-3801	203	9	pdcd1	pdcd1	NOUN
fnp-3801	203	10	or	or	CCONJ
fnp-3801	203	11	kcnb1	kcnb1	VERB
fnp-3801	203	12	present	present	VERB
fnp-3801	203	13	some	some	DET
fnp-3801	203	14	tandem	tandem	NOUN
fnp-3801	203	15	-	-	PUNCT
fnp-3801	203	16	repeat	repeat	NOUN
fnp-3801	203	17	mutations	mutation	NOUN
fnp-3801	203	18	,	,	PUNCT
fnp-3801	203	19	increasing	increase	VERB
fnp-3801	203	20	the	the	DET
fnp-3801	203	21	possibility	possibility	NOUN
fnp-3801	203	22	that	that	SCONJ
fnp-3801	203	23	these	these	DET
fnp-3801	203	24	repeats	repeat	NOUN
fnp-3801	203	25	are	be	AUX
fnp-3801	203	26	involved	involve	VERB
fnp-3801	203	27	in	in	ADP
fnp-3801	203	28	asd	asd	PROPN
fnp-3801	203	29	pathology	pathology	PROPN
fnp-3801	203	30	.	.	PUNCT
fnp-3801	204	1	in	in	ADP
fnp-3801	204	2	a	a	DET
fnp-3801	204	3	recent	recent	ADJ
fnp-3801	204	4	paper	paper	NOUN
fnp-3801	204	5	,	,	PUNCT
fnp-3801	204	6	trost	trost	PROPN
fnp-3801	204	7	et	et	PROPN
fnp-3801	204	8	al	al	PROPN
fnp-3801	204	9	.	.	PUNCT
fnp-3801	205	1	[	[	X
fnp-3801	205	2	57	57	NUM
fnp-3801	205	3	]	]	PUNCT
fnp-3801	205	4	also	also	ADV
fnp-3801	205	5	analyzed	analyze	VERB
fnp-3801	205	6	the	the	DET
fnp-3801	205	7	role	role	NOUN
fnp-3801	205	8	of	of	ADP
fnp-3801	205	9	trs	trs	PROPN
fnp-3801	205	10	in	in	ADP
fnp-3801	205	11	asd	asd	PROPN
fnp-3801	205	12	but	but	CCONJ
fnp-3801	205	13	with	with	ADP
fnp-3801	205	14	a	a	DET
fnp-3801	205	15	different	different	ADJ
fnp-3801	205	16	approach	approach	NOUN
fnp-3801	205	17	,	,	PUNCT
fnp-3801	205	18	not	not	PART
fnp-3801	205	19	taking	take	VERB
fnp-3801	205	20	into	into	ADP
fnp-3801	205	21	account	account	NOUN
fnp-3801	205	22	the	the	DET
fnp-3801	205	23	appearance	appearance	NOUN
fnp-3801	205	24	of	of	ADP
fnp-3801	205	25	de	de	X
fnp-3801	205	26	novo	novo	NOUN
fnp-3801	205	27	mutations	mutation	NOUN
fnp-3801	205	28	.	.	PUNCT
fnp-3801	206	1	this	this	DET
fnp-3801	206	2	study	study	NOUN
fnp-3801	206	3	used	use	VERB
fnp-3801	206	4	three	three	NUM
fnp-3801	206	5	times	time	NOUN
fnp-3801	206	6	more	more	ADJ
fnp-3801	206	7	genomes	genome	NOUN
fnp-3801	206	8	as	as	SCONJ
fnp-3801	206	9	compared	compare	VERB
fnp-3801	206	10	to	to	ADP
fnp-3801	206	11	the	the	DET
fnp-3801	206	12	analysis	analysis	NOUN
fnp-3801	206	13	of	of	ADP
fnp-3801	206	14	mitra	mitra	PROPN
fnp-3801	206	15	et	et	PROPN
fnp-3801	206	16	al	al	PROPN
fnp-3801	206	17	.	.	PROPN
fnp-3801	206	18	,	,	PUNCT
fnp-3801	206	19	thus	thus	ADV
fnp-3801	206	20	substantially	substantially	ADV
fnp-3801	206	21	increasing	increase	VERB
fnp-3801	206	22	the	the	DET
fnp-3801	206	23	statistical	statistical	ADJ
fnp-3801	206	24	power	power	NOUN
fnp-3801	206	25	.	.	PUNCT
fnp-3801	207	1	although	although	SCONJ
fnp-3801	207	2	the	the	DET
fnp-3801	207	3	studies	study	NOUN
fnp-3801	207	4	identified	identify	VERB
fnp-3801	207	5	different	different	ADJ
fnp-3801	207	6	mutations	mutation	NOUN
fnp-3801	207	7	,	,	PUNCT
fnp-3801	207	8	probably	probably	ADV
fnp-3801	207	9	due	due	ADP
fnp-3801	207	10	to	to	ADP
fnp-3801	207	11	the	the	DET
fnp-3801	207	12	differences	difference	NOUN
fnp-3801	207	13	in	in	ADP
fnp-3801	207	14	their	their	PRON
fnp-3801	207	15	methodological	methodological	ADJ
fnp-3801	207	16	approach	approach	NOUN
fnp-3801	207	17	,	,	PUNCT
fnp-3801	207	18	they	they	PRON
fnp-3801	207	19	were	be	AUX
fnp-3801	207	20	more	more	ADV
fnp-3801	207	21	complementary	complementary	ADJ
fnp-3801	207	22	than	than	ADP
fnp-3801	207	23	controversial	controversial	ADJ
fnp-3801	207	24	.	.	PUNCT
fnp-3801	208	1	interestingly	interestingly	ADV
fnp-3801	208	2	,	,	PUNCT
fnp-3801	208	3	the	the	DET
fnp-3801	208	4	study	study	NOUN
fnp-3801	208	5	from	from	ADP
fnp-3801	208	6	trost	trost	PROPN
fnp-3801	208	7	et	et	PROPN
fnp-3801	208	8	al	al	PROPN
fnp-3801	208	9	.	.	PROPN
fnp-3801	208	10	relates	relate	VERB
fnp-3801	208	11	several	several	ADJ
fnp-3801	208	12	trs	trs	PROPN
fnp-3801	208	13	expansions	expansion	NOUN
fnp-3801	208	14	with	with	ADP
fnp-3801	208	15	particular	particular	ADJ
fnp-3801	208	16	clinical	clinical	ADJ
fnp-3801	208	17	features	feature	NOUN
fnp-3801	208	18	like	like	ADP
fnp-3801	208	19	cognitive	cognitive	ADJ
fnp-3801	208	20	disturbances	disturbance	NOUN
fnp-3801	208	21	.	.	PUNCT
fnp-3801	209	1	the	the	DET
fnp-3801	209	2	findings	finding	NOUN
fnp-3801	209	3	open	open	VERB
fnp-3801	209	4	a	a	DET
fnp-3801	209	5	new	new	ADJ
fnp-3801	209	6	research	research	NOUN
fnp-3801	209	7	line	line	NOUN
fnp-3801	209	8	that	that	PRON
fnp-3801	209	9	could	could	AUX
fnp-3801	209	10	contribute	contribute	VERB
fnp-3801	209	11	to	to	PART
fnp-3801	209	12	disentangle	disentangle	VERB
fnp-3801	209	13	the	the	DET
fnp-3801	209	14	contribution	contribution	NOUN
fnp-3801	209	15	of	of	ADP
fnp-3801	209	16	trs	trs	PROPN
fnp-3801	209	17	to	to	ADP
fnp-3801	209	18	other	other	ADJ
fnp-3801	209	19	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	209	20	disorders	disorder	NOUN
fnp-3801	209	21	and	and	CCONJ
fnp-3801	209	22	pathologies	pathology	NOUN
fnp-3801	209	23	.	.	PUNCT
fnp-3801	210	1	however	however	ADV
fnp-3801	210	2	,	,	PUNCT
fnp-3801	210	3	the	the	DET
fnp-3801	210	4	most	most	ADV
fnp-3801	210	5	critical	critical	ADJ
fnp-3801	210	6	question	question	NOUN
fnp-3801	210	7	now	now	ADV
fnp-3801	210	8	is	be	AUX
fnp-3801	210	9	how	how	SCONJ
fnp-3801	210	10	these	these	DET
fnp-3801	210	11	alterations	alteration	NOUN
fnp-3801	210	12	in	in	ADP
fnp-3801	210	13	trs	trs	PROPN
fnp-3801	210	14	generate	generate	NOUN
fnp-3801	210	15	disturbances	disturbance	NOUN
fnp-3801	210	16	in	in	ADP
fnp-3801	210	17	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	210	18	processes	process	NOUN
fnp-3801	210	19	,	,	PUNCT
fnp-3801	210	20	accounting	account	VERB
fnp-3801	210	21	for	for	ADP
fnp-3801	210	22	the	the	DET
fnp-3801	210	23	multifactorial	multifactorial	ADJ
fnp-3801	210	24	nature	nature	NOUN
fnp-3801	210	25	of	of	ADP
fnp-3801	210	26	asd	asd	NOUN
fnp-3801	210	27	with	with	ADP
fnp-3801	210	28	the	the	DET
fnp-3801	210	29	environment	environment	NOUN
fnp-3801	210	30	playing	play	VERB
fnp-3801	210	31	a	a	DET
fnp-3801	210	32	pivotal	pivotal	ADJ
fnp-3801	210	33	role	role	NOUN
fnp-3801	210	34	,	,	PUNCT
fnp-3801	210	35	thus	thus	ADV
fnp-3801	210	36	opening	open	VERB
fnp-3801	210	37	the	the	DET
fnp-3801	210	38	question	question	NOUN
fnp-3801	210	39	of	of	ADP
fnp-3801	210	40	how	how	SCONJ
fnp-3801	210	41	the	the	DET
fnp-3801	210	42	environment	environment	NOUN
fnp-3801	210	43	interacts	interact	VERB
fnp-3801	210	44	with	with	ADP
fnp-3801	210	45	these	these	DET
fnp-3801	210	46	alterations	alteration	NOUN
fnp-3801	210	47	in	in	ADP
fnp-3801	210	48	trs	trs	PROPN
fnp-3801	210	49	.	.	PUNCT
fnp-3801	211	1	key	key	ADJ
fnp-3801	211	2	switch	switch	NOUN
fnp-3801	211	3	between	between	ADP
fnp-3801	211	4	chromatin	chromatin	NOUN
fnp-3801	211	5	remodeler	remodel	ADJ
fnp-3801	211	6	baf	baf	PROPN
fnp-3801	211	7	subunits	subunit	NOUN
fnp-3801	211	8	explains	explain	VERB
fnp-3801	211	9	coffin	coffin	NOUN
fnp-3801	211	10	-	-	PUNCT
fnp-3801	211	11	siris	siris	NOUN
fnp-3801	211	12	syndrome	syndrome	PROPN
fnp-3801	211	13	neuropathology	neuropathology	NOUN
fnp-3801	211	14	the	the	DET
fnp-3801	211	15	brain	brain	NOUN
fnp-3801	211	16	exhibits	exhibit	VERB
fnp-3801	211	17	an	an	DET
fnp-3801	211	18	extraordinarily	extraordinarily	ADV
fnp-3801	211	19	precise	precise	ADJ
fnp-3801	211	20	morphogenesis	morphogenesis	NOUN
fnp-3801	211	21	that	that	PRON
fnp-3801	211	22	leads	lead	VERB
fnp-3801	211	23	to	to	ADP
fnp-3801	211	24	the	the	DET
fnp-3801	211	25	correct	correct	ADJ
fnp-3801	211	26	cell	cell	NOUN
fnp-3801	211	27	types	type	NOUN
fnp-3801	211	28	and	and	CCONJ
fnp-3801	211	29	proportions	proportion	NOUN
fnp-3801	211	30	at	at	ADP
fnp-3801	211	31	the	the	DET
fnp-3801	211	32	appropriate	appropriate	ADJ
fnp-3801	211	33	sites	site	NOUN
fnp-3801	211	34	.	.	PUNCT
fnp-3801	212	1	during	during	ADP
fnp-3801	212	2	the	the	DET
fnp-3801	212	3	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	212	4	processes	process	NOUN
fnp-3801	212	5	that	that	PRON
fnp-3801	212	6	lead	lead	VERB
fnp-3801	212	7	to	to	ADP
fnp-3801	212	8	the	the	DET
fnp-3801	212	9	formation	formation	NOUN
fnp-3801	212	10	of	of	ADP
fnp-3801	212	11	the	the	DET
fnp-3801	212	12	central	central	ADJ
fnp-3801	212	13	nervous	nervous	ADJ
fnp-3801	212	14	system	system	NOUN
fnp-3801	212	15	,	,	PUNCT
fnp-3801	212	16	cell	cell	NOUN
fnp-3801	212	17	fate	fate	NOUN
fnp-3801	212	18	is	be	AUX
fnp-3801	212	19	acquired	acquire	VERB
fnp-3801	212	20	by	by	ADP
fnp-3801	212	21	the	the	DET
fnp-3801	212	22	decline	decline	NOUN
fnp-3801	212	23	in	in	ADP
fnp-3801	212	24	neural	neural	ADJ
fnp-3801	212	25	stem	stem	NOUN
fnp-3801	212	26	cell	cell	NOUN
fnp-3801	212	27	self	self	NOUN
fnp-3801	212	28	-	-	PUNCT
fnp-3801	212	29	renewal	renewal	NOUN
fnp-3801	212	30	and	and	CCONJ
fnp-3801	212	31	amplification	amplification	NOUN
fnp-3801	212	32	potential	potential	NOUN
fnp-3801	212	33	to	to	PART
fnp-3801	212	34	give	give	VERB
fnp-3801	212	35	rise	rise	NOUN
fnp-3801	212	36	to	to	ADP
fnp-3801	212	37	fate	fate	NOUN
fnp-3801	212	38	-	-	PUNCT
fnp-3801	212	39	committed	commit	VERB
fnp-3801	212	40	progenitors	progenitor	NOUN
fnp-3801	212	41	that	that	PRON
fnp-3801	212	42	will	will	AUX
fnp-3801	212	43	ultimately	ultimately	ADV
fnp-3801	212	44	undergo	undergo	VERB
fnp-3801	212	45	differentiation	differentiation	NOUN
fnp-3801	212	46	into	into	ADP
fnp-3801	212	47	neurons	neuron	NOUN
fnp-3801	212	48	(	(	PUNCT
fnp-3801	212	49	neurogenic	neurogenic	ADJ
fnp-3801	212	50	)	)	PUNCT
fnp-3801	212	51	or	or	CCONJ
fnp-3801	212	52	glial	glial	ADJ
fnp-3801	212	53	cells	cell	NOUN
fnp-3801	212	54	(	(	PUNCT
fnp-3801	212	55	gliogenic	gliogenic	ADJ
fnp-3801	212	56	)	)	PUNCT
fnp-3801	213	1	[	[	X
fnp-3801	213	2	58	58	NUM
fnp-3801	213	3	]	]	PUNCT
fnp-3801	213	4	.	.	PUNCT
fnp-3801	214	1	the	the	DET
fnp-3801	214	2	establishment	establishment	NOUN
fnp-3801	214	3	of	of	ADP
fnp-3801	214	4	these	these	DET
fnp-3801	214	5	cell	cell	NOUN
fnp-3801	214	6	fates	fate	NOUN
fnp-3801	214	7	requires	require	VERB
fnp-3801	214	8	the	the	DET
fnp-3801	214	9	orchestration	orchestration	NOUN
fnp-3801	214	10	of	of	ADP
fnp-3801	214	11	timely	timely	ADJ
fnp-3801	214	12	regulated	regulated	ADJ
fnp-3801	214	13	gene	gene	NOUN
fnp-3801	214	14	expression	expression	NOUN
fnp-3801	214	15	programs	program	NOUN
fnp-3801	214	16	which	which	PRON
fnp-3801	214	17	,	,	PUNCT
fnp-3801	214	18	in	in	ADP
fnp-3801	214	19	turn	turn	NOUN
fnp-3801	214	20	,	,	PUNCT
fnp-3801	214	21	depend	depend	VERB
fnp-3801	214	22	upon	upon	SCONJ
fnp-3801	214	23	epigenetic	epigenetic	ADJ
fnp-3801	214	24	and	and	CCONJ
fnp-3801	214	25	chromatin	chromatin	NOUN
fnp-3801	214	26	regulators	regulator	NOUN
fnp-3801	214	27	.	.	PUNCT
fnp-3801	215	1	atp	atp	NOUN
fnp-3801	215	2	-	-	PUNCT
fnp-3801	215	3	dependent	dependent	ADJ
fnp-3801	215	4	chromatin	chromatin	NOUN
fnp-3801	215	5	remodeling	remodeling	NOUN
fnp-3801	215	6	factors	factor	NOUN
fnp-3801	215	7	have	have	AUX
fnp-3801	215	8	been	be	AUX
fnp-3801	215	9	described	describe	VERB
fnp-3801	215	10	to	to	PART
fnp-3801	215	11	be	be	AUX
fnp-3801	215	12	vigorous	vigorous	ADJ
fnp-3801	215	13	regulators	regulator	NOUN
fnp-3801	215	14	of	of	ADP
fnp-3801	215	15	chromatin	chromatin	NOUN
fnp-3801	215	16	state	state	NOUN
fnp-3801	215	17	and	and	CCONJ
fnp-3801	215	18	dna	dna	PROPN
fnp-3801	215	19	accessibility	accessibility	NOUN
fnp-3801	215	20	,	,	PUNCT
fnp-3801	215	21	both	both	PRON
fnp-3801	215	22	of	of	ADP
fnp-3801	215	23	which	which	PRON
fnp-3801	215	24	have	have	VERB
fnp-3801	215	25	an	an	DET
fnp-3801	215	26	important	important	ADJ
fnp-3801	215	27	impact	impact	NOUN
fnp-3801	215	28	on	on	ADP
fnp-3801	215	29	the	the	DET
fnp-3801	215	30	coordination	coordination	NOUN
fnp-3801	215	31	of	of	ADP
fnp-3801	215	32	gene	gene	NOUN
fnp-3801	215	33	expression	expression	NOUN
fnp-3801	215	34	.	.	PUNCT
fnp-3801	216	1	interestingly	interestingly	ADV
fnp-3801	216	2	,	,	PUNCT
fnp-3801	216	3	a	a	DET
fnp-3801	216	4	substantial	substantial	ADJ
fnp-3801	216	5	proportion	proportion	NOUN
fnp-3801	216	6	of	of	ADP
fnp-3801	216	7	ndd	ndd	PROPN
fnp-3801	216	8	associated	associate	VERB
fnp-3801	216	9	genes	gene	NOUN
fnp-3801	216	10	are	be	AUX
fnp-3801	216	11	involved	involve	VERB
fnp-3801	216	12	in	in	ADP
fnp-3801	216	13	chromatin	chromatin	NOUN
fnp-3801	216	14	and/or	and/or	CCONJ
fnp-3801	216	15	transcriptional	transcriptional	ADJ
fnp-3801	216	16	regulation	regulation	NOUN
fnp-3801	216	17	including	include	VERB
fnp-3801	216	18	the	the	DET
fnp-3801	216	19	broad	broad	ADJ
fnp-3801	216	20	family	family	NOUN
fnp-3801	216	21	of	of	ADP
fnp-3801	216	22	atp	atp	PROPN
fnp-3801	216	23	-	-	PUNCT
fnp-3801	216	24	dependent	dependent	ADJ
fnp-3801	216	25	chromatin	chromatin	NOUN
fnp-3801	216	26	remodelers	remodeler	NOUN
fnp-3801	216	27	including	include	VERB
fnp-3801	216	28	the	the	DET
fnp-3801	216	29	multi	multi	ADJ
fnp-3801	216	30	-	-	ADJ
fnp-3801	216	31	subunit	subunit	ADJ
fnp-3801	216	32	brg1	brg1	PROPN
fnp-3801	216	33	/	/	SYM
fnp-3801	216	34	brm	brm	NOUN
fnp-3801	216	35	associated	associate	VERB
fnp-3801	216	36	factor	factor	NOUN
fnp-3801	216	37	(	(	PUNCT
fnp-3801	216	38	baf	baf	PROPN
fnp-3801	216	39	)	)	PUNCT
fnp-3801	216	40	chromatin	chromatin	NOUN
fnp-3801	216	41	modifier	modifier	NOUN
fnp-3801	216	42	family	family	NOUN
fnp-3801	216	43	,	,	PUNCT
fnp-3801	216	44	also	also	ADV
fnp-3801	216	45	known	know	VERB
fnp-3801	216	46	as	as	ADP
fnp-3801	216	47	switch	switch	NOUN
fnp-3801	216	48	/	/	SYM
fnp-3801	216	49	sucrose	sucrose	NOUN
fnp-3801	216	50	non	non	ADJ
fnp-3801	216	51	-	-	ADJ
fnp-3801	216	52	fermentable	fermentable	ADJ
fnp-3801	216	53	(	(	PUNCT
fnp-3801	216	54	mswi	mswi	NOUN
fnp-3801	216	55	/	/	SYM
fnp-3801	216	56	snf	snf	PROPN
fnp-3801	216	57	)	)	PUNCT
fnp-3801	216	58	chromatin	chromatin	NOUN
fnp-3801	216	59	remodeling	remodeling	NOUN
fnp-3801	216	60	complex	complex	NOUN
fnp-3801	216	61	.	.	PUNCT
fnp-3801	217	1	a	a	DET
fnp-3801	217	2	dna	dna	NOUN
fnp-3801	217	3	-	-	PUNCT
fnp-3801	217	4	binding	bind	VERB
fnp-3801	217	5	domain	domain	NOUN
fnp-3801	217	6	targets	target	VERB
fnp-3801	217	7	the	the	DET
fnp-3801	217	8	swi	swi	PROPN
fnp-3801	217	9	/	/	SYM
fnp-3801	217	10	snf	snf	PROPN
fnp-3801	217	11	complex	complex	NOUN
fnp-3801	217	12	to	to	ADP
fnp-3801	217	13	specific	specific	ADJ
fnp-3801	217	14	genes	gene	NOUN
fnp-3801	217	15	and	and	CCONJ
fnp-3801	217	16	facilitates	facilitate	VERB
fnp-3801	217	17	dna	dna	PROPN
fnp-3801	217	18	access	access	NOUN
fnp-3801	217	19	for	for	ADP
fnp-3801	217	20	transcription	transcription	NOUN
fnp-3801	217	21	factors	factor	NOUN
fnp-3801	217	22	.	.	PUNCT
fnp-3801	218	1	these	these	DET
fnp-3801	218	2	complexes	complex	NOUN
fnp-3801	218	3	play	play	VERB
fnp-3801	218	4	a	a	DET
fnp-3801	218	5	central	central	ADJ
fnp-3801	218	6	role	role	NOUN
fnp-3801	218	7	in	in	ADP
fnp-3801	218	8	different	different	ADJ
fnp-3801	218	9	developmental	developmental	ADJ
fnp-3801	218	10	processes	process	NOUN
fnp-3801	218	11	.	.	PUNCT
fnp-3801	219	1	all	all	PRON
fnp-3801	219	2	described	describe	VERB
fnp-3801	219	3	canonical	canonical	ADJ
fnp-3801	219	4	configurations	configuration	NOUN
fnp-3801	219	5	of	of	ADP
fnp-3801	219	6	baf	baf	PROPN
fnp-3801	219	7	require	require	VERB
fnp-3801	219	8	the	the	DET
fnp-3801	219	9	presence	presence	NOUN
fnp-3801	219	10	of	of	ADP
fnp-3801	219	11	a	a	DET
fnp-3801	219	12	subunit	subunit	NOUN
fnp-3801	219	13	containing	contain	VERB
fnp-3801	219	14	an	an	DET
fnp-3801	219	15	at	at	ADP
fnp-3801	219	16	-	-	PUNCT
fnp-3801	219	17	rich	rich	ADJ
fnp-3801	219	18	dna	dna	NOUN
fnp-3801	219	19	binding	bind	VERB
fnp-3801	219	20	domain	domain	NOUN
fnp-3801	219	21	(	(	PUNCT
fnp-3801	219	22	arid	arid	NOUN
fnp-3801	219	23	)	)	PUNCT
fnp-3801	219	24	.	.	PUNCT
fnp-3801	220	1	namely	namely	ADV
fnp-3801	220	2	,	,	PUNCT
fnp-3801	220	3	arid1b	arid1b	NOUN
fnp-3801	220	4	and	and	CCONJ
fnp-3801	220	5	its	its	PRON
fnp-3801	220	6	paralog	paralog	NOUN
fnp-3801	220	7	arid1a	arid1a	PROPN
fnp-3801	220	8	encode	encode	ADJ
fnp-3801	220	9	for	for	ADP
fnp-3801	220	10	the	the	DET
fnp-3801	220	11	two	two	NUM
fnp-3801	220	12	largest	large	ADJ
fnp-3801	220	13	,	,	PUNCT
fnp-3801	220	14	mutually	mutually	ADV
fnp-3801	220	15	exclusive	exclusive	ADJ
fnp-3801	220	16	,	,	PUNCT
fnp-3801	220	17	subunits	subunit	NOUN
fnp-3801	220	18	of	of	ADP
fnp-3801	220	19	the	the	DET
fnp-3801	220	20	complex	complex	NOUN
fnp-3801	220	21	:	:	PUNCT
fnp-3801	220	22	arid1a	arid1a	PROPN
fnp-3801	220	23	and	and	CCONJ
fnp-3801	220	24	arid1b	arid1b	NOUN
fnp-3801	220	25	.	.	PUNCT
fnp-3801	221	1	interestingly	interestingly	ADV
fnp-3801	221	2	,	,	PUNCT
fnp-3801	221	3	the	the	DET
fnp-3801	221	4	arid1b	arid1b	NOUN
fnp-3801	221	5	gene	gene	NOUN
fnp-3801	221	6	,	,	PUNCT
fnp-3801	221	7	but	but	CCONJ
fnp-3801	221	8	not	not	PART
fnp-3801	221	9	arid1a	arid1a	PROPN
fnp-3801	221	10	,	,	PUNCT
fnp-3801	221	11	is	be	AUX
fnp-3801	221	12	among	among	ADP
fnp-3801	221	13	the	the	DET
fnp-3801	221	14	most	most	ADV
fnp-3801	221	15	commonly	commonly	ADV
fnp-3801	221	16	mutated	mutate	VERB
fnp-3801	221	17	genes	gene	NOUN
fnp-3801	221	18	in	in	ADP
fnp-3801	221	19	asd	asd	NOUN
fnp-3801	221	20	and	and	CCONJ
fnp-3801	221	21	in	in	ADP
fnp-3801	221	22	syndromic	syndromic	ADJ
fnp-3801	221	23	and	and	CCONJ
fnp-3801	221	24	non	non	ADJ
fnp-3801	221	25	-	-	ADJ
fnp-3801	221	26	syndromic	syndromic	ADJ
fnp-3801	221	27	ids	id	NOUN
fnp-3801	221	28	[	[	X
fnp-3801	221	29	59	59	NUM
fnp-3801	221	30	]	]	PUNCT
fnp-3801	221	31	.	.	PUNCT
fnp-3801	222	1	mutations	mutation	NOUN
fnp-3801	222	2	observed	observe	VERB
fnp-3801	222	3	include	include	VERB
fnp-3801	222	4	deletions	deletion	NOUN
fnp-3801	222	5	and	and	CCONJ
fnp-3801	222	6	truncations	truncation	NOUN
fnp-3801	222	7	due	due	ADJ
fnp-3801	222	8	to	to	ADP
fnp-3801	222	9	de	de	X
fnp-3801	222	10	novo	novo	NOUN
fnp-3801	222	11	nonsense	nonsense	NOUN
fnp-3801	222	12	or	or	CCONJ
fnp-3801	222	13	frameshift	frameshift	ADJ
fnp-3801	222	14	mutations	mutation	NOUN
fnp-3801	222	15	as	as	ADV
fnp-3801	222	16	well	well	ADV
fnp-3801	222	17	as	as	ADP
fnp-3801	222	18	translocations	translocation	NOUN
fnp-3801	222	19	leading	lead	VERB
fnp-3801	222	20	to	to	ADP
fnp-3801	222	21	arid1b	arid1b	NOUN
fnp-3801	222	22	haploinsufficiency	haploinsufficiency	PROPN
fnp-3801	222	23	in	in	ADP
fnp-3801	222	24	the	the	DET
fnp-3801	222	25	individuals	individual	NOUN
fnp-3801	222	26	with	with	ADP
fnp-3801	222	27	intellectual	intellectual	ADJ
fnp-3801	222	28	disability	disability	NOUN
fnp-3801	222	29	.	.	PUNCT
fnp-3801	223	1	furthermore	furthermore	ADV
fnp-3801	223	2	,	,	PUNCT
fnp-3801	223	3	de	de	X
fnp-3801	223	4	novo	novo	NOUN
fnp-3801	223	5	haploinsufficient	haploinsufficient	ADJ
fnp-3801	223	6	mutations	mutation	NOUN
fnp-3801	223	7	in	in	ADP
fnp-3801	223	8	this	this	DET
fnp-3801	223	9	gene	gene	NOUN
fnp-3801	223	10	are	be	AUX
fnp-3801	223	11	found	find	VERB
fnp-3801	223	12	in	in	ADP
fnp-3801	223	13	~75	~75	ADV
fnp-3801	223	14	%	%	NOUN
fnp-3801	223	15	of	of	ADP
fnp-3801	223	16	coffin	coffin	NOUN
fnp-3801	223	17	-	-	PUNCT
fnp-3801	223	18	siris	siris	NOUN
fnp-3801	223	19	syndrome	syndrome	NOUN
fnp-3801	223	20	patients	patient	NOUN
fnp-3801	223	21	,	,	PUNCT
fnp-3801	223	22	a	a	DET
fnp-3801	223	23	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	223	24	condition	condition	NOUN
fnp-3801	223	25	characterized	characterize	VERB
fnp-3801	223	26	by	by	ADP
fnp-3801	223	27	learning	learn	VERB
fnp-3801	223	28	disability	disability	NOUN
fnp-3801	223	29	and	and	CCONJ
fnp-3801	223	30	craniofacial	craniofacial	ADJ
fnp-3801	223	31	features	feature	NOUN
fnp-3801	223	32	.	.	PUNCT
fnp-3801	224	1	despite	despite	SCONJ
fnp-3801	224	2	the	the	DET
fnp-3801	224	3	biochemical	biochemical	ADJ
fnp-3801	224	4	knowledge	knowledge	NOUN
fnp-3801	224	5	on	on	ADP
fnp-3801	224	6	their	their	PRON
fnp-3801	224	7	mechanisms	mechanism	NOUN
fnp-3801	224	8	of	of	ADP
fnp-3801	224	9	action	action	NOUN
fnp-3801	224	10	,	,	PUNCT
fnp-3801	224	11	the	the	DET
fnp-3801	224	12	roles	role	NOUN
fnp-3801	224	13	of	of	ADP
fnp-3801	224	14	chromatin	chromatin	NOUN
fnp-3801	224	15	remodeling	remodeling	NOUN
fnp-3801	224	16	factors	factor	NOUN
fnp-3801	224	17	during	during	ADP
fnp-3801	224	18	brain	brain	NOUN
fnp-3801	224	19	development	development	NOUN
fnp-3801	224	20	have	have	AUX
fnp-3801	224	21	not	not	PART
fnp-3801	224	22	been	be	AUX
fnp-3801	224	23	identified	identify	VERB
fnp-3801	224	24	.	.	PUNCT
fnp-3801	225	1	furthermore	furthermore	ADV
fnp-3801	225	2	,	,	PUNCT
fnp-3801	225	3	the	the	DET
fnp-3801	225	4	brain	brain	NOUN
fnp-3801	225	5	defects	defect	NOUN
fnp-3801	225	6	that	that	PRON
fnp-3801	225	7	arise	arise	VERB
fnp-3801	225	8	as	as	ADP
fnp-3801	225	9	a	a	DET
fnp-3801	225	10	consequence	consequence	NOUN
fnp-3801	225	11	of	of	ADP
fnp-3801	225	12	changes	change	NOUN
fnp-3801	225	13	in	in	ADP
fnp-3801	225	14	chromatin	chromatin	NOUN
fnp-3801	225	15	structure	structure	NOUN
fnp-3801	225	16	,	,	PUNCT
fnp-3801	225	17	dynamics	dynamic	NOUN
fnp-3801	225	18	and	and	CCONJ
fnp-3801	225	19	function	function	NOUN
fnp-3801	225	20	remain	remain	VERB
fnp-3801	225	21	largely	largely	ADV
fnp-3801	225	22	unexplored	unexplored	ADJ
fnp-3801	225	23	.	.	PUNCT
fnp-3801	226	1	paglaroli	paglaroli	PROPN
fnp-3801	226	2	et	et	PROPN
fnp-3801	226	3	al	al	PROPN
fnp-3801	226	4	.	.	PUNCT
fnp-3801	227	1	[	[	X
fnp-3801	227	2	60	60	NUM
fnp-3801	227	3	]	]	PUNCT
fnp-3801	227	4	have	have	AUX
fnp-3801	227	5	studied	study	VERB
fnp-3801	227	6	the	the	DET
fnp-3801	227	7	molecular	molecular	ADJ
fnp-3801	227	8	role	role	NOUN
fnp-3801	227	9	of	of	ADP
fnp-3801	227	10	arid1b	arid1b	NOUN
fnp-3801	227	11	in	in	ADP
fnp-3801	227	12	cell	cell	NOUN
fnp-3801	227	13	fate	fate	NOUN
fnp-3801	227	14	commitment	commitment	NOUN
fnp-3801	227	15	during	during	ADP
fnp-3801	227	16	neurodevelopment	neurodevelopment	NOUN
fnp-3801	227	17	.	.	PUNCT
fnp-3801	228	1	using	use	VERB
fnp-3801	228	2	arid1b+/	arid1b+/	NOUN
fnp-3801	228	3	–	–	PUNCT
fnp-3801	228	4	coffin	coffin	NOUN
fnp-3801	228	5	-	-	PUNCT
fnp-3801	228	6	siris	siris	NOUN
fnp-3801	228	7	patient	patient	NOUN
fnp-3801	228	8	-	-	PUNCT
fnp-3801	228	9	derived	derive	VERB
fnp-3801	228	10	hipscs	hipsc	NOUN
fnp-3801	228	11	,	,	PUNCT
fnp-3801	228	12	they	they	PRON
fnp-3801	228	13	described	describe	VERB
fnp-3801	228	14	for	for	ADP
fnp-3801	228	15	the	the	DET
fnp-3801	228	16	first	first	ADJ
fnp-3801	228	17	time	time	NOUN
fnp-3801	228	18	that	that	SCONJ
fnp-3801	228	19	a	a	DET
fnp-3801	228	20	switching	switch	VERB
fnp-3801	228	21	mechanism	mechanism	NOUN
fnp-3801	228	22	between	between	ADP
fnp-3801	228	23	arid1b	arid1b	NOUN
fnp-3801	228	24	containing	contain	VERB
fnp-3801	228	25	baf	baf	PROPN
fnp-3801	228	26	(	(	PUNCT
fnp-3801	228	27	arid1b	arid1b	NOUN
fnp-3801	228	28	-	-	PUNCT
fnp-3801	228	29	baf	baf	PROPN
fnp-3801	228	30	)	)	PUNCT
fnp-3801	228	31	and	and	CCONJ
fnp-3801	228	32	arid1a	arid1a	PROPN
fnp-3801	228	33	-	-	PUNCT
fnp-3801	228	34	baf	baf	PROPN
fnp-3801	228	35	is	be	AUX
fnp-3801	228	36	required	require	VERB
fnp-3801	228	37	for	for	ADP
fnp-3801	228	38	lineage	lineage	NOUN
fnp-3801	228	39	specification	specification	NOUN
fnp-3801	228	40	and	and	CCONJ
fnp-3801	228	41	for	for	ADP
fnp-3801	228	42	exiting	exit	VERB
fnp-3801	228	43	the	the	DET
fnp-3801	228	44	pluripotent	pluripotent	ADJ
fnp-3801	228	45	state	state	NOUN
fnp-3801	228	46	.	.	PUNCT
fnp-3801	229	1	in	in	ADP
fnp-3801	229	2	pscs	psc	NOUN
fnp-3801	229	3	,	,	PUNCT
fnp-3801	229	4	pluripotency	pluripotency	NOUN
fnp-3801	229	5	is	be	AUX
fnp-3801	229	6	conveyed	convey	VERB
fnp-3801	229	7	via	via	ADP
fnp-3801	229	8	binding	bind	VERB
fnp-3801	229	9	of	of	ADP
fnp-3801	229	10	an	an	DET
fnp-3801	229	11	arid1a	arid1a	NOUN
fnp-3801	229	12	-	-	PUNCT
fnp-3801	229	13	containing	contain	VERB
fnp-3801	229	14	baf	baf	NOUN
fnp-3801	229	15	to	to	ADP
fnp-3801	229	16	pluripotency	pluripotency	NOUN
fnp-3801	229	17	-	-	PUNCT
fnp-3801	229	18	associated	associate	VERB
fnp-3801	229	19	enhancers	enhancer	NOUN
fnp-3801	229	20	of	of	ADP
fnp-3801	229	21	the	the	DET
fnp-3801	229	22	sox2	sox2	NOUN
fnp-3801	229	23	and	and	CCONJ
fnp-3801	229	24	nanog	nanog	PROPN
fnp-3801	229	25	networks	network	NOUN
fnp-3801	229	26	.	.	PUNCT
fnp-3801	230	1	in	in	ADP
fnp-3801	230	2	order	order	NOUN
fnp-3801	230	3	to	to	PART
fnp-3801	230	4	perform	perform	VERB
fnp-3801	230	5	transition	transition	NOUN
fnp-3801	230	6	to	to	ADP
fnp-3801	230	7	a	a	DET
fnp-3801	230	8	multipotent	multipotent	NOUN
fnp-3801	230	9	state	state	NOUN
fnp-3801	230	10	,	,	PUNCT
fnp-3801	230	11	arid1b	arid1b	NOUN
fnp-3801	230	12	-	-	PUNCT
fnp-3801	230	13	baf	baf	PROPN
fnp-3801	230	14	is	be	AUX
fnp-3801	230	15	transiently	transiently	ADV
fnp-3801	230	16	activated	activate	VERB
fnp-3801	230	17	to	to	PART
fnp-3801	230	18	replace	replace	VERB
fnp-3801	230	19	arid1a	arid1a	PROPN
fnp-3801	230	20	-	-	PUNCT
fnp-3801	230	21	baf	baf	PROPN
fnp-3801	230	22	at	at	ADP
fnp-3801	230	23	the	the	DET
fnp-3801	230	24	sox2	sox2	PROPN
fnp-3801	230	25	/	/	SYM
fnp-3801	230	26	nanog	nanog	PROPN
fnp-3801	230	27	enhancers	enhancer	NOUN
fnp-3801	230	28	and	and	CCONJ
fnp-3801	230	29	elicits	elicit	VERB
fnp-3801	230	30	their	their	PRON
fnp-3801	230	31	repression	repression	NOUN
fnp-3801	230	32	(	(	PUNCT
fnp-3801	230	33	see	see	VERB
fnp-3801	230	34	fig	fig	NOUN
fnp-3801	230	35	.	.	PUNCT
fnp-3801	231	1	2	2	NUM
fnp-3801	231	2	)	)	PUNCT
fnp-3801	231	3	.	.	PUNCT
fnp-3801	232	1	the	the	DET
fnp-3801	232	2	haploinsufficient	haploinsufficient	ADJ
fnp-3801	232	3	mutation	mutation	NOUN
fnp-3801	232	4	of	of	ADP
fnp-3801	232	5	arid1b	arid1b	NOUN
fnp-3801	232	6	in	in	ADP
fnp-3801	232	7	coffin	coffin	NOUN
fnp-3801	232	8	-	-	PUNCT
fnp-3801	232	9	siris	siris	NOUN
fnp-3801	232	10	syndrome	syndrome	NOUN
fnp-3801	232	11	impairs	impair	VERB
fnp-3801	232	12	the	the	DET
fnp-3801	232	13	switch	switch	NOUN
fnp-3801	232	14	from	from	ADP
fnp-3801	232	15	arid1a	arid1a	NOUN
fnp-3801	232	16	-	-	PUNCT
fnp-3801	232	17	baf	baf	PROPN
fnp-3801	232	18	to	to	ADP
fnp-3801	232	19	arid1b	arid1b	NOUN
fnp-3801	232	20	-	-	PUNCT
fnp-3801	232	21	baf	baf	PROPN
fnp-3801	232	22	,	,	PUNCT
fnp-3801	232	23	thus	thus	ADV
fnp-3801	232	24	maintaining	maintain	VERB
fnp-3801	232	25	arid1a	arid1a	PROPN
fnp-3801	232	26	-	-	PUNCT
fnp-3801	232	27	baf	baf	PROPN
fnp-3801	232	28	at	at	ADP
fnp-3801	232	29	pluripotency	pluripotency	ADJ
fnp-3801	232	30	enhancers	enhancer	NOUN
fnp-3801	232	31	.	.	PUNCT
fnp-3801	233	1	this	this	PRON
fnp-3801	233	2	leads	lead	VERB
fnp-3801	233	3	to	to	ADP
fnp-3801	233	4	aberrant	aberrant	ADJ
fnp-3801	233	5	binding	binding	NOUN
fnp-3801	233	6	of	of	ADP
fnp-3801	233	7	sox2	sox2	NOUN
fnp-3801	233	8	that	that	PRON
fnp-3801	233	9	interferes	interfere	VERB
fnp-3801	233	10	with	with	ADP
fnp-3801	233	11	the	the	DET
fnp-3801	233	12	gene	gene	NOUN
fnp-3801	233	13	expression	expression	NOUN
fnp-3801	233	14	patterns	pattern	NOUN
fnp-3801	233	15	required	require	VERB
fnp-3801	233	16	for	for	ADP
fnp-3801	233	17	neurodevelopment	neurodevelopment	NOUN
fnp-3801	233	18	.	.	PUNCT
fnp-3801	234	1	altogether	altogether	ADV
fnp-3801	234	2	,	,	PUNCT
fnp-3801	234	3	these	these	DET
fnp-3801	234	4	alterations	alteration	NOUN
fnp-3801	234	5	result	result	VERB
fnp-3801	234	6	in	in	ADP
fnp-3801	234	7	an	an	DET
fnp-3801	234	8	impaired	impaired	ADJ
fnp-3801	234	9	cranial	cranial	ADJ
fnp-3801	234	10	neural	neural	ADJ
fnp-3801	234	11	crest	crest	NOUN
fnp-3801	234	12	differentiation	differentiation	NOUN
fnp-3801	234	13	that	that	PRON
fnp-3801	234	14	accounts	account	VERB
fnp-3801	234	15	for	for	ADP
fnp-3801	234	16	the	the	DET
fnp-3801	234	17	phenotypes	phenotype	NOUN
fnp-3801	234	18	observed	observe	VERB
fnp-3801	234	19	in	in	ADP
fnp-3801	234	20	coffin	coffin	NOUN
fnp-3801	234	21	-	-	PUNCT
fnp-3801	234	22	siris	siris	NOUN
fnp-3801	234	23	patients	patient	NOUN
fnp-3801	234	24	.	.	PUNCT
fnp-3801	235	1	these	these	DET
fnp-3801	235	2	findings	finding	NOUN
fnp-3801	235	3	provide	provide	VERB
fnp-3801	235	4	the	the	DET
fnp-3801	235	5	molecular	molecular	ADJ
fnp-3801	235	6	mechanisms	mechanism	NOUN
fnp-3801	235	7	underlying	underlie	VERB
fnp-3801	235	8	not	not	PART
fnp-3801	235	9	only	only	ADV
fnp-3801	235	10	coffin	coffin	NOUN
fnp-3801	235	11	-	-	PUNCT
fnp-3801	235	12	siris	siris	NOUN
fnp-3801	235	13	syndrome	syndrome	NOUN
fnp-3801	235	14	but	but	CCONJ
fnp-3801	235	15	also	also	ADV
fnp-3801	235	16	in	in	ADP
fnp-3801	235	17	some	some	DET
fnp-3801	235	18	non	non	ADJ
fnp-3801	235	19	-	-	ADJ
fnp-3801	235	20	syndromic	syndromic	ADJ
fnp-3801	235	21	ids	id	NOUN
fnp-3801	235	22	and	and	CCONJ
fnp-3801	235	23	asd	asd	NOUN
fnp-3801	235	24	in	in	ADP
fnp-3801	235	25	which	which	PRON
fnp-3801	235	26	arid1b	arid1b	NOUN
fnp-3801	235	27	is	be	AUX
fnp-3801	235	28	frequently	frequently	ADV
fnp-3801	235	29	mutated	mutate	VERB
fnp-3801	235	30	[	[	X
fnp-3801	235	31	59	59	NUM
fnp-3801	235	32	]	]	PUNCT
fnp-3801	235	33	.	.	PUNCT
fnp-3801	236	1	fig	fig	NOUN
fnp-3801	236	2	.	.	PUNCT
fnp-3801	237	1	2	2	NUM
fnp-3801	237	2	.	.	X
fnp-3801	237	3	schematic	schematic	ADJ
fnp-3801	237	4	representation	representation	NOUN
fnp-3801	237	5	of	of	ADP
fnp-3801	237	6	arid1a	arid1a	PROPN
fnp-3801	237	7	-	-	PUNCT
fnp-3801	237	8	baf	baf	PROPN
fnp-3801	237	9	switch	switch	NOUN
fnp-3801	237	10	to	to	ADP
fnp-3801	237	11	arid1b	arid1b	NOUN
fnp-3801	237	12	-	-	PUNCT
fnp-3801	237	13	baf	baf	PROPN
fnp-3801	237	14	during	during	ADP
fnp-3801	237	15	psc	psc	PROPN
fnp-3801	237	16	to	to	PART
fnp-3801	237	17	multipotent	multipotent	VERB
fnp-3801	237	18	state	state	NOUN
fnp-3801	237	19	transition	transition	NOUN
fnp-3801	237	20	(	(	PUNCT
fnp-3801	237	21	top	top	NOUN
fnp-3801	237	22	)	)	PUNCT
fnp-3801	237	23	.	.	PUNCT
fnp-3801	238	1	in	in	ADP
fnp-3801	238	2	arid1b+/mutations	arid1b+/mutation	NOUN
fnp-3801	238	3	,	,	PUNCT
fnp-3801	238	4	arid1a	arid1a	NOUN
fnp-3801	238	5	-	-	PUNCT
fnp-3801	238	6	baf	baf	PROPN
fnp-3801	238	7	is	be	AUX
fnp-3801	238	8	maintained	maintain	VERB
fnp-3801	238	9	at	at	ADP
fnp-3801	238	10	pluripotent	pluripotent	ADJ
fnp-3801	238	11	enhancers	enhancer	NOUN
fnp-3801	238	12	,	,	PUNCT
fnp-3801	238	13	leading	lead	VERB
fnp-3801	238	14	to	to	ADP
fnp-3801	238	15	an	an	DET
fnp-3801	238	16	impaired	impaired	ADJ
fnp-3801	238	17	neurodevelopment	neurodevelopment	NOUN
fnp-3801	238	18	(	(	PUNCT
fnp-3801	238	19	bottom	bottom	NOUN
fnp-3801	238	20	)	)	PUNCT
fnp-3801	238	21	.	.	PUNCT
fnp-3801	239	1	trnas	trnas	PROPN
fnp-3801	239	2	methylation	methylation	NOUN
fnp-3801	239	3	and	and	CCONJ
fnp-3801	239	4	intellectual	intellectual	ADJ
fnp-3801	239	5	disability	disability	NOUN
fnp-3801	239	6	transfer	transfer	NOUN
fnp-3801	239	7	rnas	rna	NOUN
fnp-3801	239	8	(	(	PUNCT
fnp-3801	239	9	trna	trna	PROPN
fnp-3801	239	10	)	)	PUNCT
fnp-3801	239	11	are	be	AUX
fnp-3801	239	12	small	small	ADJ
fnp-3801	239	13	and	and	CCONJ
fnp-3801	239	14	highly	highly	ADV
fnp-3801	239	15	abundant	abundant	ADJ
fnp-3801	239	16	rna	rna	NOUN
fnp-3801	239	17	molecules	molecule	NOUN
fnp-3801	239	18	in	in	ADP
fnp-3801	239	19	the	the	DET
fnp-3801	239	20	cell	cell	NOUN
fnp-3801	239	21	,	,	PUNCT
fnp-3801	239	22	representing	represent	VERB
fnp-3801	239	23	around	around	ADP
fnp-3801	239	24	10	10	NUM
fnp-3801	239	25	%	%	NOUN
fnp-3801	239	26	of	of	ADP
fnp-3801	239	27	the	the	DET
fnp-3801	239	28	total	total	ADJ
fnp-3801	239	29	cell	cell	NOUN
fnp-3801	239	30	’s	’s	PART
fnp-3801	239	31	rna	rna	NOUN
fnp-3801	239	32	pool	pool	NOUN
fnp-3801	239	33	[	[	X
fnp-3801	239	34	61	61	NUM
fnp-3801	239	35	]	]	PUNCT
fnp-3801	239	36	.	.	PUNCT
fnp-3801	240	1	trna	trna	PROPN
fnp-3801	240	2	help	help	AUX
fnp-3801	240	3	decode	decode	VERB
fnp-3801	240	4	a	a	DET
fnp-3801	240	5	messenger	messenger	NOUN
fnp-3801	240	6	rna	rna	NOUN
fnp-3801	240	7	(	(	PUNCT
fnp-3801	240	8	mrna	mrna	PROPN
fnp-3801	240	9	)	)	PUNCT
fnp-3801	240	10	sequence	sequence	NOUN
fnp-3801	240	11	into	into	ADP
fnp-3801	240	12	a	a	DET
fnp-3801	240	13	protein	protein	NOUN
fnp-3801	240	14	,	,	PUNCT
fnp-3801	240	15	coupling	couple	VERB
fnp-3801	240	16	transcriptional	transcriptional	ADJ
fnp-3801	240	17	and	and	CCONJ
fnp-3801	240	18	translational	translational	ADJ
fnp-3801	240	19	processes	process	NOUN
fnp-3801	240	20	.	.	PUNCT
fnp-3801	241	1	trnas	trnas	PROPN
fnp-3801	241	2	are	be	AUX
fnp-3801	241	3	highly	highly	ADV
fnp-3801	241	4	structured	structured	ADJ
fnp-3801	241	5	and	and	CCONJ
fnp-3801	241	6	contain	contain	VERB
fnp-3801	241	7	a	a	DET
fnp-3801	241	8	high	high	ADJ
fnp-3801	241	9	number	number	NOUN
fnp-3801	241	10	of	of	ADP
fnp-3801	241	11	post	post	ADJ
fnp-3801	241	12	-	-	ADJ
fnp-3801	241	13	translational	translational	ADJ
fnp-3801	241	14	modifications	modification	NOUN
fnp-3801	241	15	such	such	ADJ
fnp-3801	241	16	as	as	ADP
fnp-3801	241	17	methylation	methylation	NOUN
fnp-3801	241	18	and	and	CCONJ
fnp-3801	241	19	acylation	acylation	NOUN
fnp-3801	241	20	.	.	PUNCT
fnp-3801	242	1	these	these	DET
fnp-3801	242	2	modifications	modification	NOUN
fnp-3801	242	3	contribute	contribute	VERB
fnp-3801	242	4	to	to	ADP
fnp-3801	242	5	the	the	DET
fnp-3801	242	6	stability	stability	NOUN
fnp-3801	242	7	and	and	CCONJ
fnp-3801	242	8	integrity	integrity	NOUN
fnp-3801	242	9	of	of	ADP
fnp-3801	242	10	trnas	trnas	NOUN
fnp-3801	242	11	,	,	PUNCT
fnp-3801	242	12	to	to	ADP
fnp-3801	242	13	the	the	DET
fnp-3801	242	14	codon	codon	NOUN
fnp-3801	242	15	-	-	PUNCT
fnp-3801	242	16	anticodon	anticodon	NOUN
fnp-3801	242	17	interaction	interaction	NOUN
fnp-3801	242	18	,	,	PUNCT
fnp-3801	242	19	which	which	PRON
fnp-3801	242	20	contributes	contribute	VERB
fnp-3801	242	21	to	to	ADP
fnp-3801	242	22	translation	translation	NOUN
fnp-3801	242	23	efficiency	efficiency	NOUN
fnp-3801	242	24	and	and	CCONJ
fnp-3801	242	25	to	to	ADP
fnp-3801	242	26	the	the	DET
fnp-3801	242	27	rna	rna	NOUN
fnp-3801	242	28	quality	quality	NOUN
fnp-3801	242	29	control	control	NOUN
fnp-3801	242	30	and	and	CCONJ
fnp-3801	242	31	regulation	regulation	NOUN
fnp-3801	242	32	of	of	ADP
fnp-3801	242	33	trna	trna	NOUN
fnp-3801	242	34	localization	localization	NOUN
fnp-3801	242	35	in	in	ADP
fnp-3801	242	36	the	the	DET
fnp-3801	242	37	cell	cell	NOUN
fnp-3801	242	38	.	.	PUNCT
fnp-3801	243	1	neuronal	neuronal	ADJ
fnp-3801	243	2	function	function	NOUN
fnp-3801	243	3	requires	require	VERB
fnp-3801	243	4	high	high	ADJ
fnp-3801	243	5	translation	translation	NOUN
fnp-3801	243	6	efficiency	efficiency	NOUN
fnp-3801	243	7	due	due	ADP
fnp-3801	243	8	to	to	ADP
fnp-3801	243	9	the	the	DET
fnp-3801	243	10	high	high	ADJ
fnp-3801	243	11	translation	translation	NOUN
fnp-3801	243	12	rate	rate	NOUN
fnp-3801	243	13	and	and	CCONJ
fnp-3801	243	14	alterations	alteration	NOUN
fnp-3801	243	15	in	in	ADP
fnp-3801	243	16	translation	translation	NOUN
fnp-3801	243	17	are	be	AUX
fnp-3801	243	18	now	now	ADV
fnp-3801	243	19	considered	consider	VERB
fnp-3801	243	20	a	a	DET
fnp-3801	243	21	pivotal	pivotal	ADJ
fnp-3801	243	22	pathogenic	pathogenic	ADJ
fnp-3801	243	23	mechanism	mechanism	NOUN
fnp-3801	243	24	in	in	ADP
fnp-3801	243	25	several	several	ADJ
fnp-3801	243	26	neurologic	neurologic	ADJ
fnp-3801	243	27	disorders	disorder	NOUN
fnp-3801	243	28	,	,	PUNCT
fnp-3801	243	29	especially	especially	ADV
fnp-3801	243	30	in	in	ADP
fnp-3801	243	31	ndds	ndd	NOUN
fnp-3801	244	1	[	[	X
fnp-3801	244	2	62	62	NUM
fnp-3801	244	3	]	]	PUNCT
fnp-3801	244	4	.	.	PUNCT
fnp-3801	245	1	one	one	NUM
fnp-3801	245	2	of	of	ADP
fnp-3801	245	3	the	the	DET
fnp-3801	245	4	most	most	ADV
fnp-3801	245	5	common	common	ADJ
fnp-3801	245	6	trna	trna	NOUN
fnp-3801	245	7	modifications	modification	NOUN
fnp-3801	245	8	is	be	AUX
fnp-3801	245	9	methylation	methylation	NOUN
fnp-3801	245	10	,	,	PUNCT
fnp-3801	245	11	with	with	ADP
fnp-3801	245	12	more	more	ADJ
fnp-3801	245	13	than	than	ADP
fnp-3801	245	14	30	30	NUM
fnp-3801	245	15	methylated	methylate	VERB
fnp-3801	245	16	nucleotides	nucleotide	NOUN
fnp-3801	245	17	found	find	VERB
fnp-3801	245	18	at	at	ADP
fnp-3801	245	19	different	different	ADJ
fnp-3801	245	20	positions	position	NOUN
fnp-3801	245	21	in	in	ADP
fnp-3801	245	22	trnas	trnas	NOUN
fnp-3801	245	23	.	.	PUNCT
fnp-3801	246	1	trnas	trnas	PROPN
fnp-3801	246	2	methylation	methylation	NOUN
fnp-3801	246	3	is	be	AUX
fnp-3801	246	4	fundamental	fundamental	ADJ
fnp-3801	246	5	for	for	ADP
fnp-3801	246	6	the	the	DET
fnp-3801	246	7	normal	normal	ADJ
fnp-3801	246	8	function	function	NOUN
fnp-3801	246	9	of	of	ADP
fnp-3801	246	10	different	different	ADJ
fnp-3801	246	11	organs	organ	NOUN
fnp-3801	246	12	,	,	PUNCT
fnp-3801	246	13	and	and	CCONJ
fnp-3801	246	14	the	the	DET
fnp-3801	246	15	disruption	disruption	NOUN
fnp-3801	246	16	of	of	ADP
fnp-3801	246	17	this	this	DET
fnp-3801	246	18	process	process	NOUN
fnp-3801	246	19	is	be	AUX
fnp-3801	246	20	associated	associate	VERB
fnp-3801	246	21	with	with	ADP
fnp-3801	246	22	cancer	cancer	NOUN
fnp-3801	246	23	,	,	PUNCT
fnp-3801	246	24	neurodegeneration	neurodegeneration	NOUN
fnp-3801	246	25	and	and	CCONJ
fnp-3801	246	26	intellectual	intellectual	ADJ
fnp-3801	246	27	disability	disability	NOUN
fnp-3801	246	28	(	(	PUNCT
fnp-3801	246	29	i	i	NOUN
fnp-3801	246	30	d	d	PROPN
fnp-3801	246	31	)	)	PUNCT
fnp-3801	246	32	and	and	CCONJ
fnp-3801	246	33	neurological	neurological	ADJ
fnp-3801	246	34	phenotypes	phenotype	NOUN
fnp-3801	246	35	are	be	AUX
fnp-3801	246	36	often	often	ADV
fnp-3801	246	37	the	the	DET
fnp-3801	246	38	primary	primary	ADJ
fnp-3801	246	39	manifestation	manifestation	NOUN
fnp-3801	246	40	of	of	ADP
fnp-3801	246	41	mutations	mutation	NOUN
fnp-3801	246	42	affecting	affect	VERB
fnp-3801	246	43	the	the	DET
fnp-3801	246	44	trna	trna	NOUN
fnp-3801	246	45	regulome	regulome	NOUN
fnp-3801	246	46	[	[	X
fnp-3801	246	47	63	63	NUM
fnp-3801	246	48	,	,	PUNCT
fnp-3801	246	49	64	64	NUM
fnp-3801	246	50	]	]	PUNCT
fnp-3801	246	51	.	.	PUNCT
fnp-3801	247	1	trna	trna	PROPN
fnp-3801	247	2	methyltransferase	methyltransferase	NOUN
fnp-3801	247	3	genes	gene	NOUN
fnp-3801	247	4	such	such	ADJ
fnp-3801	247	5	as	as	ADP
fnp-3801	247	6	trmt10a	trmt10a	NOUN
fnp-3801	247	7	,	,	PUNCT
fnp-3801	247	8	trmt1	trmt1	PROPN
fnp-3801	247	9	,	,	PUNCT
fnp-3801	247	10	ftsj1	ftsj1	PROPN
fnp-3801	247	11	,	,	PUNCT
fnp-3801	247	12	elp1	elp1	PROPN
fnp-3801	247	13	,	,	PUNCT
fnp-3801	247	14	wdr4	wdr4	NOUN
fnp-3801	247	15	and	and	CCONJ
fnp-3801	247	16	nsun2	nsun2	NOUN
fnp-3801	247	17	have	have	AUX
fnp-3801	247	18	been	be	AUX
fnp-3801	247	19	linked	link	VERB
fnp-3801	247	20	to	to	ADP
fnp-3801	247	21	different	different	ADJ
fnp-3801	247	22	forms	form	NOUN
fnp-3801	247	23	of	of	ADP
fnp-3801	247	24	i	i	PROPN
fnp-3801	247	25	d	d	PROPN
fnp-3801	248	1	[	[	X
fnp-3801	248	2	65	65	NUM
fnp-3801	248	3	-	-	SYM
fnp-3801	248	4	67	67	NUM
fnp-3801	248	5	]	]	PUNCT
fnp-3801	248	6	.	.	PUNCT
fnp-3801	249	1	the	the	DET
fnp-3801	249	2	human	human	PROPN
fnp-3801	249	3	ftsj1rna	ftsj1rna	PROPN
fnp-3801	249	4	2’-o	2’-o	PROPN
fnp-3801	249	5	-	-	NOUN
fnp-3801	249	6	methyltransferase	methyltransferase	NOUN
fnp-3801	249	7	1	1	NUM
fnp-3801	249	8	(	(	PUNCT
fnp-3801	249	9	ftsj1	ftsj1	PROPN
fnp-3801	249	10	)	)	PUNCT
fnp-3801	249	11	gene	gene	NOUN
fnp-3801	249	12	is	be	AUX
fnp-3801	249	13	located	locate	VERB
fnp-3801	249	14	on	on	ADP
fnp-3801	249	15	the	the	DET
fnp-3801	249	16	x	x	NOUN
fnp-3801	249	17	chromosome	chromosome	NOUN
fnp-3801	249	18	and	and	CCONJ
fnp-3801	249	19	several	several	ADJ
fnp-3801	249	20	mutations	mutation	NOUN
fnp-3801	249	21	in	in	ADP
fnp-3801	249	22	this	this	DET
fnp-3801	249	23	gene	gene	NOUN
fnp-3801	249	24	have	have	AUX
fnp-3801	249	25	been	be	AUX
fnp-3801	249	26	associated	associate	VERB
fnp-3801	249	27	with	with	ADP
fnp-3801	249	28	the	the	DET
fnp-3801	249	29	development	development	NOUN
fnp-3801	249	30	of	of	ADP
fnp-3801	249	31	x	x	ADJ
fnp-3801	249	32	-	-	ADJ
fnp-3801	249	33	linked	link	VERB
fnp-3801	249	34	intellectual	intellectual	ADJ
fnp-3801	249	35	disability	disability	NOUN
fnp-3801	249	36	(	(	PUNCT
fnp-3801	249	37	xlid	xlid	PROPN
fnp-3801	249	38	)	)	PUNCT
fnp-3801	249	39	in	in	ADP
fnp-3801	249	40	several	several	ADJ
fnp-3801	249	41	families	family	NOUN
fnp-3801	249	42	[	[	X
fnp-3801	249	43	68	68	NUM
fnp-3801	249	44	]	]	PUNCT
fnp-3801	249	45	.	.	PUNCT
fnp-3801	250	1	nagayoshi	nagayoshi	PROPN
fnp-3801	250	2	et	et	PROPN
fnp-3801	250	3	al	al	PROPN
fnp-3801	250	4	.	.	PROPN
fnp-3801	250	5	have	have	AUX
fnp-3801	250	6	analyzed	analyze	VERB
fnp-3801	250	7	why	why	SCONJ
fnp-3801	250	8	the	the	DET
fnp-3801	250	9	loss	loss	NOUN
fnp-3801	250	10	of	of	ADP
fnp-3801	250	11	ftsj1	ftsj1	NOUN
fnp-3801	250	12	and	and	CCONJ
fnp-3801	250	13	its	its	PRON
fnp-3801	250	14	methyltransferase	methyltransferase	NOUN
fnp-3801	250	15	activity	activity	NOUN
fnp-3801	250	16	would	would	AUX
fnp-3801	250	17	lead	lead	VERB
fnp-3801	250	18	to	to	ADP
fnp-3801	250	19	the	the	DET
fnp-3801	250	20	development	development	NOUN
fnp-3801	250	21	of	of	ADP
fnp-3801	250	22	i	i	PROPN
fnp-3801	250	23	d	d	PROPN
fnp-3801	250	24	despite	despite	SCONJ
fnp-3801	250	25	its	its	PRON
fnp-3801	250	26	ubiquitous	ubiquitous	ADJ
fnp-3801	250	27	expression	expression	NOUN
fnp-3801	250	28	[	[	X
fnp-3801	250	29	69	69	NUM
fnp-3801	250	30	]	]	PUNCT
fnp-3801	250	31	.	.	PUNCT
fnp-3801	251	1	using	use	VERB
fnp-3801	251	2	ftsj1	ftsj1	PROPN
fnp-3801	251	3	ko	ko	PROPN
fnp-3801	251	4	mice	mice	PROPN
fnp-3801	251	5	and	and	CCONJ
fnp-3801	251	6	xlid	xlid	PROPN
fnp-3801	251	7	patient	patient	NOUN
fnp-3801	251	8	-	-	PUNCT
fnp-3801	251	9	derived	derive	VERB
fnp-3801	251	10	cells	cell	NOUN
fnp-3801	251	11	,	,	PUNCT
fnp-3801	251	12	they	they	PRON
fnp-3801	251	13	observed	observe	VERB
fnp-3801	251	14	a	a	DET
fnp-3801	251	15	reduction	reduction	NOUN
fnp-3801	251	16	in	in	ADP
fnp-3801	251	17	2’o	2’o	ADV
fnp-3801	251	18	-	-	PUNCT
fnp-3801	251	19	methylated	methylate	VERB
fnp-3801	251	20	nucleotides	nucleotide	NOUN
fnp-3801	251	21	in	in	ADP
fnp-3801	251	22	11	11	NUM
fnp-3801	251	23	species	specie	NOUN
fnp-3801	251	24	of	of	ADP
fnp-3801	251	25	trna	trna	NOUN
fnp-3801	251	26	including	include	VERB
fnp-3801	251	27	trnaphe	trnaphe	NOUN
fnp-3801	251	28	,	,	PUNCT
fnp-3801	251	29	a	a	DET
fnp-3801	251	30	ftsj1	ftsj1	NOUN
fnp-3801	251	31	substrate	substrate	NOUN
fnp-3801	251	32	.	.	PUNCT
fnp-3801	252	1	among	among	ADP
fnp-3801	252	2	all	all	DET
fnp-3801	252	3	trna	trna	PROPN
fnp-3801	252	4	species	specie	NOUN
fnp-3801	252	5	,	,	PUNCT
fnp-3801	252	6	trnaphe	trnaphe	NOUN
fnp-3801	252	7	is	be	AUX
fnp-3801	252	8	the	the	DET
fnp-3801	252	9	most	most	ADV
fnp-3801	252	10	reduced	reduce	VERB
fnp-3801	252	11	in	in	ADP
fnp-3801	252	12	ftsj1	ftsj1	PROPN
fnp-3801	252	13	ko	ko	PROPN
fnp-3801	252	14	mouse	mouse	PROPN
fnp-3801	252	15	brain	brain	NOUN
fnp-3801	252	16	compared	compare	VERB
fnp-3801	252	17	to	to	ADP
fnp-3801	252	18	the	the	DET
fnp-3801	252	19	subtle	subtle	ADJ
fnp-3801	252	20	reduction	reduction	NOUN
fnp-3801	252	21	of	of	ADP
fnp-3801	252	22	the	the	DET
fnp-3801	252	23	other	other	ADJ
fnp-3801	252	24	trnas	trnas	NOUN
fnp-3801	252	25	.	.	PUNCT
fnp-3801	253	1	trna	trna	NOUN
fnp-3801	253	2	-	-	PUNCT
fnp-3801	253	3	sequencing	sequencing	NOUN
fnp-3801	253	4	demonstrated	demonstrate	VERB
fnp-3801	253	5	an	an	DET
fnp-3801	253	6	accumulation	accumulation	NOUN
fnp-3801	253	7	of	of	ADP
fnp-3801	253	8	fragments	fragment	NOUN
fnp-3801	253	9	of	of	ADP
fnp-3801	253	10	trnaphe	trnaphe	NOUN
fnp-3801	253	11	in	in	ADP
fnp-3801	253	12	the	the	DET
fnp-3801	253	13	ftsj1	ftsj1	PROPN
fnp-3801	253	14	ko	ko	PROPN
fnp-3801	253	15	mouse	mouse	PROPN
fnp-3801	253	16	brains	brain	NOUN
fnp-3801	253	17	.	.	PUNCT
fnp-3801	254	1	these	these	DET
fnp-3801	254	2	findings	finding	NOUN
fnp-3801	254	3	revealed	reveal	VERB
fnp-3801	254	4	that	that	SCONJ
fnp-3801	254	5	the	the	DET
fnp-3801	254	6	absence	absence	NOUN
fnp-3801	254	7	of	of	ADP
fnp-3801	254	8	the	the	DET
fnp-3801	254	9	ftsj1	ftsj1	PROPN
fnp-3801	254	10	methylation	methylation	NOUN
fnp-3801	254	11	leads	lead	VERB
fnp-3801	254	12	to	to	ADP
fnp-3801	254	13	a	a	DET
fnp-3801	254	14	cleavage	cleavage	NOUN
fnp-3801	254	15	in	in	ADP
fnp-3801	254	16	specific	specific	ADJ
fnp-3801	254	17	positions	position	NOUN
fnp-3801	254	18	,	,	PUNCT
fnp-3801	254	19	and	and	CCONJ
fnp-3801	254	20	,	,	PUNCT
fnp-3801	254	21	ultimately	ultimately	ADV
fnp-3801	254	22	,	,	PUNCT
fnp-3801	254	23	to	to	PART
fnp-3801	254	24	perturbed	perturb	VERB
fnp-3801	254	25	decoding	decode	VERB
fnp-3801	254	26	at	at	ADP
fnp-3801	254	27	phenylalanine	phenylalanine	NOUN
fnp-3801	254	28	(	(	PUNCT
fnp-3801	254	29	phe	phe	NOUN
fnp-3801	254	30	)	)	PUNCT
fnp-3801	254	31	codons	codon	NOUN
fnp-3801	254	32	.	.	PUNCT
fnp-3801	255	1	the	the	DET
fnp-3801	255	2	authors	author	NOUN
fnp-3801	255	3	hypothesized	hypothesize	VERB
fnp-3801	255	4	that	that	SCONJ
fnp-3801	255	5	alterations	alteration	NOUN
fnp-3801	255	6	in	in	ADP
fnp-3801	255	7	phe	phe	PROPN
fnp-3801	255	8	codon	codon	PROPN
fnp-3801	255	9	translation	translation	NOUN
fnp-3801	255	10	leads	lead	VERB
fnp-3801	255	11	to	to	ADP
fnp-3801	255	12	dysfunction	dysfunction	NOUN
fnp-3801	255	13	in	in	ADP
fnp-3801	255	14	the	the	DET
fnp-3801	255	15	translation	translation	NOUN
fnp-3801	255	16	of	of	ADP
fnp-3801	255	17	fundamental	fundamental	ADJ
fnp-3801	255	18	proteins	protein	NOUN
fnp-3801	255	19	for	for	ADP
fnp-3801	255	20	neuron	neuron	NOUN
fnp-3801	255	21	function	function	NOUN
fnp-3801	255	22	as	as	SCONJ
fnp-3801	255	23	they	they	PRON
fnp-3801	255	24	found	find	VERB
fnp-3801	255	25	dysregulation	dysregulation	NOUN
fnp-3801	255	26	in	in	ADP
fnp-3801	255	27	genes	gene	NOUN
fnp-3801	255	28	involved	involve	VERB
fnp-3801	255	29	in	in	ADP
fnp-3801	255	30	synapse	synapse	NOUN
fnp-3801	255	31	organization	organization	NOUN
fnp-3801	255	32	and	and	CCONJ
fnp-3801	255	33	cell	cell	NOUN
fnp-3801	255	34	projection	projection	NOUN
fnp-3801	255	35	,	,	PUNCT
fnp-3801	255	36	including	include	VERB
fnp-3801	255	37	wnt7b	wnt7b	PROPN
fnp-3801	255	38	and	and	CCONJ
fnp-3801	255	39	ctnnb1	ctnnb1	NOUN
fnp-3801	255	40	as	as	ADP
fnp-3801	255	41	two	two	NUM
fnp-3801	255	42	interesting	interesting	ADJ
fnp-3801	255	43	candidates	candidate	NOUN
fnp-3801	255	44	related	relate	VERB
fnp-3801	255	45	to	to	ADP
fnp-3801	255	46	the	the	DET
fnp-3801	255	47	wnt	wnt	NOUN
fnp-3801	255	48	signaling	signal	VERB
fnp-3801	255	49	pathway	pathway	NOUN
fnp-3801	255	50	[	[	X
fnp-3801	255	51	70	70	NUM
fnp-3801	255	52	]	]	PUNCT
fnp-3801	255	53	.	.	PUNCT
fnp-3801	256	1	ftsj1	ftsj1	PROPN
fnp-3801	256	2	ko	ko	PROPN
fnp-3801	256	3	showed	show	VERB
fnp-3801	256	4	an	an	DET
fnp-3801	256	5	increase	increase	NOUN
fnp-3801	256	6	of	of	ADP
fnp-3801	256	7	thin	thin	ADJ
fnp-3801	256	8	dendritic	dendritic	ADJ
fnp-3801	256	9	spines	spine	NOUN
fnp-3801	256	10	indicating	indicate	VERB
fnp-3801	256	11	immaturity	immaturity	NOUN
fnp-3801	256	12	of	of	ADP
fnp-3801	256	13	synapses	synapsis	NOUN
fnp-3801	256	14	,	,	PUNCT
fnp-3801	256	15	and	and	CCONJ
fnp-3801	256	16	a	a	DET
fnp-3801	256	17	decrease	decrease	NOUN
fnp-3801	256	18	in	in	ADP
fnp-3801	256	19	the	the	DET
fnp-3801	256	20	length	length	NOUN
fnp-3801	256	21	and	and	CCONJ
fnp-3801	256	22	width	width	NOUN
fnp-3801	256	23	of	of	ADP
fnp-3801	256	24	the	the	DET
fnp-3801	256	25	postsynaptic	postsynaptic	ADJ
fnp-3801	256	26	density	density	NOUN
fnp-3801	256	27	indicating	indicate	VERB
fnp-3801	256	28	alterations	alteration	NOUN
fnp-3801	256	29	in	in	ADP
fnp-3801	256	30	connectivity	connectivity	NOUN
fnp-3801	256	31	.	.	PUNCT
fnp-3801	257	1	finally	finally	ADV
fnp-3801	257	2	,	,	PUNCT
fnp-3801	257	3	the	the	DET
fnp-3801	257	4	authors	author	NOUN
fnp-3801	257	5	demonstrate	demonstrate	VERB
fnp-3801	257	6	that	that	SCONJ
fnp-3801	257	7	ftsj1	ftsj1	PROPN
fnp-3801	257	8	ko	ko	PROPN
fnp-3801	257	9	mice	mice	PROPN
fnp-3801	257	10	show	show	PROPN
fnp-3801	257	11	altered	alter	VERB
fnp-3801	257	12	ltp	ltp	PROPN
fnp-3801	257	13	and	and	CCONJ
fnp-3801	257	14	ltd	ltd	PROPN
fnp-3801	257	15	,	,	PUNCT
fnp-3801	257	16	and	and	CCONJ
fnp-3801	257	17	behavioral	behavioral	ADJ
fnp-3801	257	18	impairment	impairment	NOUN
fnp-3801	257	19	with	with	ADP
fnp-3801	257	20	increased	increase	VERB
fnp-3801	257	21	anxiety	anxiety	NOUN
fnp-3801	257	22	,	,	PUNCT
fnp-3801	257	23	slower	slow	ADJ
fnp-3801	257	24	spatial	spatial	ADJ
fnp-3801	257	25	learning	learning	NOUN
fnp-3801	257	26	and	and	CCONJ
fnp-3801	257	27	poor	poor	ADJ
fnp-3801	257	28	associative	associative	ADJ
fnp-3801	257	29	learning	learning	NOUN
fnp-3801	257	30	.	.	PUNCT
fnp-3801	258	1	these	these	DET
fnp-3801	258	2	results	result	NOUN
fnp-3801	258	3	establish	establish	VERB
fnp-3801	258	4	for	for	ADP
fnp-3801	258	5	the	the	DET
fnp-3801	258	6	first	first	ADJ
fnp-3801	258	7	time	time	NOUN
fnp-3801	258	8	how	how	SCONJ
fnp-3801	258	9	alterations	alteration	NOUN
fnp-3801	258	10	in	in	ADP
fnp-3801	258	11	the	the	DET
fnp-3801	258	12	normal	normal	ADJ
fnp-3801	258	13	physiology	physiology	NOUN
fnp-3801	258	14	of	of	ADP
fnp-3801	258	15	trna	trna	PROPN
fnp-3801	258	16	methyltransferases	methyltransferase	NOUN
fnp-3801	258	17	lead	lead	VERB
fnp-3801	258	18	to	to	ADP
fnp-3801	258	19	aberrant	aberrant	ADJ
fnp-3801	258	20	translation	translation	NOUN
fnp-3801	258	21	,	,	PUNCT
fnp-3801	258	22	altered	alter	VERB
fnp-3801	258	23	cell	cell	NOUN
fnp-3801	258	24	biology	biology	NOUN
fnp-3801	258	25	,	,	PUNCT
fnp-3801	258	26	impaired	impaired	ADJ
fnp-3801	258	27	electrophysiological	electrophysiological	ADJ
fnp-3801	258	28	properties	property	NOUN
fnp-3801	258	29	and	and	CCONJ
fnp-3801	258	30	,	,	PUNCT
fnp-3801	258	31	ultimately	ultimately	ADV
fnp-3801	258	32	,	,	PUNCT
fnp-3801	258	33	behavioral	behavioral	ADJ
fnp-3801	258	34	deterioration	deterioration	NOUN
fnp-3801	258	35	.	.	PUNCT
fnp-3801	259	1	mitovesicles	mitovesicle	NOUN
fnp-3801	259	2	:	:	PUNCT
fnp-3801	259	3	a	a	DET
fnp-3801	259	4	new	new	ADJ
fnp-3801	259	5	player	player	NOUN
fnp-3801	259	6	in	in	ADP
fnp-3801	259	7	the	the	DET
fnp-3801	259	8	neuropathology	neuropathology	NOUN
fnp-3801	259	9	of	of	ADP
fnp-3801	259	10	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	259	11	disorders	disorder	NOUN
fnp-3801	259	12	mitochondria	mitochondria	VERB
fnp-3801	259	13	,	,	PUNCT
fnp-3801	259	14	the	the	DET
fnp-3801	259	15	organelles	organelle	NOUN
fnp-3801	259	16	classically	classically	ADV
fnp-3801	259	17	seen	see	VERB
fnp-3801	259	18	as	as	ADP
fnp-3801	259	19	the	the	DET
fnp-3801	259	20	powerhouse	powerhouse	NOUN
fnp-3801	259	21	of	of	ADP
fnp-3801	259	22	the	the	DET
fnp-3801	259	23	cell	cell	NOUN
fnp-3801	259	24	,	,	PUNCT
fnp-3801	259	25	also	also	ADV
fnp-3801	259	26	play	play	VERB
fnp-3801	259	27	a	a	DET
fnp-3801	259	28	role	role	NOUN
fnp-3801	259	29	in	in	ADP
fnp-3801	259	30	a	a	DET
fnp-3801	259	31	plethora	plethora	NOUN
fnp-3801	259	32	of	of	ADP
fnp-3801	259	33	crucial	crucial	ADJ
fnp-3801	259	34	cellular	cellular	ADJ
fnp-3801	259	35	functions	function	NOUN
fnp-3801	259	36	,	,	PUNCT
fnp-3801	259	37	from	from	ADP
fnp-3801	259	38	regulation	regulation	NOUN
fnp-3801	259	39	of	of	ADP
fnp-3801	259	40	calcium	calcium	NOUN
fnp-3801	259	41	homeostasis	homeostasis	NOUN
fnp-3801	259	42	,	,	PUNCT
fnp-3801	259	43	initiation	initiation	NOUN
fnp-3801	259	44	of	of	ADP
fnp-3801	259	45	apoptosis	apoptosis	NOUN
fnp-3801	259	46	,	,	PUNCT
fnp-3801	259	47	thermoregulation	thermoregulation	NOUN
fnp-3801	259	48	,	,	PUNCT
fnp-3801	259	49	red	red	ADJ
fnp-3801	259	50	-	-	PUNCT
fnp-3801	259	51	ox	ox	NOUN
fnp-3801	259	52	balance	balance	NOUN
fnp-3801	259	53	,	,	PUNCT
fnp-3801	259	54	to	to	ADP
fnp-3801	259	55	epigenetic	epigenetic	ADJ
fnp-3801	259	56	regulation	regulation	NOUN
fnp-3801	259	57	by	by	ADP
fnp-3801	259	58	means	mean	NOUN
fnp-3801	259	59	of	of	ADP
fnp-3801	259	60	methylation	methylation	NOUN
fnp-3801	259	61	,	,	PUNCT
fnp-3801	259	62	acetylation	acetylation	NOUN
fnp-3801	259	63	,	,	PUNCT
fnp-3801	259	64	or	or	CCONJ
fnp-3801	259	65	phosphorylation	phosphorylation	NOUN
fnp-3801	259	66	.	.	PUNCT
fnp-3801	260	1	genes	gene	NOUN
fnp-3801	260	2	encoding	encode	VERB
fnp-3801	260	3	mitochondrial	mitochondrial	ADJ
fnp-3801	260	4	proteins	protein	NOUN
fnp-3801	260	5	are	be	AUX
fnp-3801	260	6	increasingly	increasingly	ADV
fnp-3801	260	7	associated	associate	VERB
fnp-3801	260	8	with	with	ADP
fnp-3801	260	9	a	a	DET
fnp-3801	260	10	wide	wide	ADJ
fnp-3801	260	11	variety	variety	NOUN
fnp-3801	260	12	of	of	ADP
fnp-3801	260	13	ndds	ndd	NOUN
fnp-3801	260	14	such	such	ADJ
fnp-3801	260	15	as	as	ADP
fnp-3801	260	16	epileptic	epileptic	ADJ
fnp-3801	260	17	encephalopathy	encephalopathy	NOUN
fnp-3801	260	18	,	,	PUNCT
fnp-3801	260	19	i	i	PROPN
fnp-3801	260	20	d	d	PROPN
fnp-3801	260	21	,	,	PUNCT
fnp-3801	260	22	or	or	CCONJ
fnp-3801	260	23	asd	asd	NOUN
fnp-3801	260	24	and	and	CCONJ
fnp-3801	260	25	recent	recent	ADJ
fnp-3801	260	26	reports	report	NOUN
fnp-3801	260	27	show	show	VERB
fnp-3801	260	28	that	that	SCONJ
fnp-3801	260	29	proteins	protein	NOUN
fnp-3801	260	30	associated	associate	VERB
fnp-3801	260	31	with	with	ADP
fnp-3801	260	32	intellectual	intellectual	ADJ
fnp-3801	260	33	disability	disability	NOUN
fnp-3801	260	34	are	be	AUX
fnp-3801	260	35	linked	link	VERB
fnp-3801	260	36	to	to	ADP
fnp-3801	260	37	mitochondrial	mitochondrial	ADJ
fnp-3801	260	38	function	function	NOUN
fnp-3801	260	39	.	.	PUNCT
fnp-3801	261	1	interestingly	interestingly	ADV
fnp-3801	261	2	,	,	PUNCT
fnp-3801	261	3	mitochondrial	mitochondrial	ADJ
fnp-3801	261	4	components	component	NOUN
fnp-3801	261	5	can	can	AUX
fnp-3801	261	6	be	be	AUX
fnp-3801	261	7	mediators	mediator	NOUN
fnp-3801	261	8	for	for	ADP
fnp-3801	261	9	intraand	intraand	X
fnp-3801	261	10	inter	inter	ADJ
fnp-3801	261	11	-	-	ADJ
fnp-3801	261	12	cellular	cellular	ADJ
fnp-3801	261	13	communication	communication	NOUN
fnp-3801	261	14	under	under	ADP
fnp-3801	261	15	physiological	physiological	ADJ
fnp-3801	261	16	and	and	CCONJ
fnp-3801	261	17	pathological	pathological	ADJ
fnp-3801	261	18	conditions	condition	NOUN
fnp-3801	261	19	,	,	PUNCT
fnp-3801	261	20	being	be	AUX
fnp-3801	261	21	transferred	transfer	VERB
fnp-3801	261	22	through	through	ADP
fnp-3801	261	23	extracellular	extracellular	ADJ
fnp-3801	261	24	vesicles	vesicle	NOUN
fnp-3801	261	25	(	(	PUNCT
fnp-3801	261	26	evs	evs	NOUN
fnp-3801	261	27	)	)	PUNCT
fnp-3801	261	28	.	.	PUNCT
fnp-3801	262	1	the	the	DET
fnp-3801	262	2	study	study	NOUN
fnp-3801	262	3	of	of	ADP
fnp-3801	262	4	evs	evs	PROPN
fnp-3801	262	5	,	,	PUNCT
fnp-3801	262	6	defined	define	VERB
fnp-3801	262	7	as	as	ADP
fnp-3801	262	8	heterogeneous	heterogeneous	ADJ
fnp-3801	262	9	nanoscale	nanoscale	NOUN
fnp-3801	262	10	vesicles	vesicle	NOUN
fnp-3801	262	11	secreted	secrete	VERB
fnp-3801	262	12	into	into	ADP
fnp-3801	262	13	the	the	DET
fnp-3801	262	14	extracellular	extracellular	ADJ
fnp-3801	262	15	space	space	NOUN
fnp-3801	262	16	,	,	PUNCT
fnp-3801	262	17	is	be	AUX
fnp-3801	262	18	a	a	DET
fnp-3801	262	19	growing	grow	VERB
fnp-3801	262	20	field	field	NOUN
fnp-3801	262	21	in	in	ADP
fnp-3801	262	22	biomedicine	biomedicine	NOUN
fnp-3801	262	23	and	and	CCONJ
fnp-3801	262	24	particularly	particularly	ADV
fnp-3801	262	25	in	in	ADP
fnp-3801	262	26	neuroscience	neuroscience	NOUN
fnp-3801	262	27	due	due	ADP
fnp-3801	262	28	to	to	ADP
fnp-3801	262	29	its	its	PRON
fnp-3801	262	30	potential	potential	NOUN
fnp-3801	262	31	as	as	ADP
fnp-3801	262	32	a	a	DET
fnp-3801	262	33	biomarker	biomarker	NOUN
fnp-3801	262	34	.	.	PUNCT
fnp-3801	263	1	microvesicles	microvesicle	NOUN
fnp-3801	263	2	and	and	CCONJ
fnp-3801	263	3	exosomes	exosome	NOUN
fnp-3801	263	4	are	be	AUX
fnp-3801	263	5	the	the	DET
fnp-3801	263	6	main	main	ADJ
fnp-3801	263	7	types	type	NOUN
fnp-3801	263	8	of	of	ADP
fnp-3801	263	9	ev	ev	NOUN
fnp-3801	263	10	,	,	PUNCT
fnp-3801	263	11	with	with	ADP
fnp-3801	263	12	subtle	subtle	ADJ
fnp-3801	263	13	differences	difference	NOUN
fnp-3801	263	14	in	in	ADP
fnp-3801	263	15	composition	composition	NOUN
fnp-3801	263	16	[	[	X
fnp-3801	263	17	71	71	NUM
fnp-3801	263	18	]	]	PUNCT
fnp-3801	263	19	.	.	PUNCT
fnp-3801	264	1	in	in	ADP
fnp-3801	264	2	a	a	DET
fnp-3801	264	3	recent	recent	ADJ
fnp-3801	264	4	study	study	NOUN
fnp-3801	264	5	,	,	PUNCT
fnp-3801	264	6	the	the	DET
fnp-3801	264	7	ability	ability	NOUN
fnp-3801	264	8	of	of	ADP
fnp-3801	264	9	evs	evs	NOUN
fnp-3801	264	10	to	to	PART
fnp-3801	264	11	transfer	transfer	VERB
fnp-3801	264	12	mitochondrial	mitochondrial	ADJ
fnp-3801	264	13	components	component	NOUN
fnp-3801	264	14	was	be	AUX
fnp-3801	264	15	examined	examine	VERB
fnp-3801	264	16	in	in	ADP
fnp-3801	264	17	fmr1	fmr1	PROPN
fnp-3801	264	18	knockout	knockout	NOUN
fnp-3801	264	19	mice	mouse	NOUN
fnp-3801	264	20	,	,	PUNCT
fnp-3801	264	21	a	a	DET
fnp-3801	264	22	model	model	NOUN
fnp-3801	264	23	of	of	ADP
fnp-3801	264	24	fxs	fxs	PROPN
fnp-3801	264	25	[	[	X
fnp-3801	264	26	72	72	NUM
fnp-3801	264	27	]	]	PUNCT
fnp-3801	264	28	.	.	PUNCT
fnp-3801	265	1	the	the	DET
fnp-3801	265	2	authors	author	NOUN
fnp-3801	265	3	found	find	VERB
fnp-3801	265	4	reduced	reduce	VERB
fnp-3801	265	5	mitochondrial	mitochondrial	ADJ
fnp-3801	265	6	components	component	NOUN
fnp-3801	265	7	in	in	ADP
fnp-3801	265	8	mitochondrial	mitochondrial	ADJ
fnp-3801	265	9	fractions	fraction	NOUN
fnp-3801	265	10	from	from	ADP
fnp-3801	265	11	cortical	cortical	ADJ
fnp-3801	265	12	tissues	tissue	NOUN
fnp-3801	265	13	and	and	CCONJ
fnp-3801	265	14	astrocytes	astrocyte	NOUN
fnp-3801	265	15	of	of	ADP
fnp-3801	265	16	fmr1	fmr1	PROPN
fnp-3801	265	17	ko	ko	PROPN
fnp-3801	265	18	mouse	mouse	PROPN
fnp-3801	265	19	brains	brain	NOUN
fnp-3801	265	20	,	,	PUNCT
fnp-3801	265	21	and	and	CCONJ
fnp-3801	265	22	were	be	AUX
fnp-3801	265	23	able	able	ADJ
fnp-3801	265	24	to	to	PART
fnp-3801	265	25	monitor	monitor	VERB
fnp-3801	265	26	mitochondrial	mitochondrial	ADJ
fnp-3801	265	27	dysfunction	dysfunction	NOUN
fnp-3801	265	28	in	in	ADP
fnp-3801	265	29	evs	evs	NOUN
fnp-3801	265	30	.	.	PUNCT
fnp-3801	266	1	in	in	ADP
fnp-3801	266	2	fact	fact	NOUN
fnp-3801	266	3	,	,	PUNCT
fnp-3801	266	4	mitochondrial	mitochondrial	ADJ
fnp-3801	266	5	components	component	NOUN
fnp-3801	266	6	are	be	AUX
fnp-3801	266	7	the	the	DET
fnp-3801	266	8	least	least	ADJ
fnp-3801	266	9	studied	study	VERB
fnp-3801	266	10	components	component	NOUN
fnp-3801	266	11	in	in	ADP
fnp-3801	266	12	evs	evs	NOUN
fnp-3801	266	13	[	[	X
fnp-3801	266	14	73	73	NUM
fnp-3801	266	15	]	]	PUNCT
fnp-3801	266	16	.	.	PUNCT
fnp-3801	267	1	during	during	ADP
fnp-3801	267	2	years	year	NOUN
fnp-3801	267	3	,	,	PUNCT
fnp-3801	267	4	there	there	PRON
fnp-3801	267	5	was	be	VERB
fnp-3801	267	6	a	a	DET
fnp-3801	267	7	controversy	controversy	NOUN
fnp-3801	267	8	about	about	ADP
fnp-3801	267	9	the	the	DET
fnp-3801	267	10	nature	nature	NOUN
fnp-3801	267	11	of	of	ADP
fnp-3801	267	12	this	this	DET
fnp-3801	267	13	secreted	secrete	VERB
fnp-3801	267	14	mitochondrial	mitochondrial	ADJ
fnp-3801	267	15	material	material	NOUN
fnp-3801	267	16	with	with	ADP
fnp-3801	267	17	evidences	evidence	NOUN
fnp-3801	267	18	suggesting	suggest	VERB
fnp-3801	267	19	the	the	DET
fnp-3801	267	20	secretion	secretion	NOUN
fnp-3801	267	21	of	of	ADP
fnp-3801	267	22	exosomes	exosome	NOUN
fnp-3801	267	23	packed	pack	VERB
fnp-3801	267	24	with	with	ADP
fnp-3801	267	25	mitochondrial	mitochondrial	ADJ
fnp-3801	267	26	material	material	NOUN
fnp-3801	267	27	or	or	CCONJ
fnp-3801	267	28	the	the	DET
fnp-3801	267	29	secretion	secretion	NOUN
fnp-3801	267	30	of	of	ADP
fnp-3801	267	31	whole	whole	ADJ
fnp-3801	267	32	mitochondria	mitochondria	NOUN
fnp-3801	267	33	,	,	PUNCT
fnp-3801	267	34	leading	lead	VERB
fnp-3801	267	35	to	to	ADP
fnp-3801	267	36	exchange	exchange	NOUN
fnp-3801	267	37	of	of	ADP
fnp-3801	267	38	these	these	DET
fnp-3801	267	39	organelles	organelle	NOUN
fnp-3801	267	40	between	between	ADP
fnp-3801	267	41	cells	cell	NOUN
fnp-3801	267	42	[	[	X
fnp-3801	267	43	74	74	NUM
fnp-3801	267	44	-	-	SYM
fnp-3801	267	45	76	76	NUM
fnp-3801	267	46	]	]	PUNCT
fnp-3801	267	47	.	.	PUNCT
fnp-3801	268	1	however	however	ADV
fnp-3801	268	2	,	,	PUNCT
fnp-3801	268	3	the	the	DET
fnp-3801	268	4	lack	lack	NOUN
fnp-3801	268	5	of	of	ADP
fnp-3801	268	6	standardized	standardized	ADJ
fnp-3801	268	7	methodologies	methodology	NOUN
fnp-3801	268	8	to	to	PART
fnp-3801	268	9	accurately	accurately	ADV
fnp-3801	268	10	separate	separate	VERB
fnp-3801	268	11	these	these	DET
fnp-3801	268	12	different	different	ADJ
fnp-3801	268	13	components	component	NOUN
fnp-3801	268	14	impeded	impede	VERB
fnp-3801	268	15	the	the	DET
fnp-3801	268	16	proper	proper	ADJ
fnp-3801	268	17	study	study	NOUN
fnp-3801	268	18	of	of	ADP
fnp-3801	268	19	the	the	DET
fnp-3801	268	20	biological	biological	ADJ
fnp-3801	268	21	mechanisms	mechanism	NOUN
fnp-3801	268	22	behind	behind	ADP
fnp-3801	268	23	the	the	DET
fnp-3801	268	24	different	different	ADJ
fnp-3801	268	25	subtypes	subtype	NOUN
fnp-3801	268	26	of	of	ADP
fnp-3801	268	27	evs	evs	NOUN
fnp-3801	268	28	[	[	X
fnp-3801	268	29	77	77	NUM
fnp-3801	268	30	]	]	PUNCT
fnp-3801	268	31	.	.	PUNCT
fnp-3801	269	1	d’acunzo	d’acunzo	NOUN
fnp-3801	269	2	et	et	PROPN
fnp-3801	269	3	al	al	PROPN
fnp-3801	269	4	.	.	PROPN
fnp-3801	269	5	now	now	ADV
fnp-3801	269	6	developed	develop	VERB
fnp-3801	269	7	a	a	DET
fnp-3801	269	8	new	new	ADJ
fnp-3801	269	9	method	method	NOUN
fnp-3801	269	10	based	base	VERB
fnp-3801	269	11	on	on	ADP
fnp-3801	269	12	density	density	NOUN
fnp-3801	269	13	gradients	gradient	NOUN
fnp-3801	269	14	to	to	PART
fnp-3801	269	15	achieve	achieve	VERB
fnp-3801	269	16	high	high	ADJ
fnp-3801	269	17	resolution	resolution	NOUN
fnp-3801	269	18	isolation	isolation	NOUN
fnp-3801	269	19	of	of	ADP
fnp-3801	269	20	different	different	ADJ
fnp-3801	269	21	ev	ev	NOUN
fnp-3801	269	22	subpopulations	subpopulation	NOUN
fnp-3801	269	23	.	.	PUNCT
fnp-3801	270	1	this	this	DET
fnp-3801	270	2	new	new	ADJ
fnp-3801	270	3	method	method	NOUN
fnp-3801	270	4	led	lead	VERB
fnp-3801	270	5	to	to	ADP
fnp-3801	270	6	the	the	DET
fnp-3801	270	7	finding	finding	NOUN
fnp-3801	270	8	of	of	ADP
fnp-3801	270	9	a	a	DET
fnp-3801	270	10	new	new	ADJ
fnp-3801	270	11	class	class	NOUN
fnp-3801	270	12	of	of	ADP
fnp-3801	270	13	previously	previously	ADV
fnp-3801	270	14	unknown	unknown	ADJ
fnp-3801	270	15	,	,	PUNCT
fnp-3801	270	16	mitochondria	mitochondria	NOUN
fnp-3801	270	17	-	-	PUNCT
fnp-3801	270	18	derived	derive	VERB
fnp-3801	270	19	evs	evs	NOUN
fnp-3801	270	20	[	[	X
fnp-3801	270	21	78	78	NUM
fnp-3801	270	22	]	]	PUNCT
fnp-3801	270	23	.	.	PUNCT
fnp-3801	271	1	first	first	ADV
fnp-3801	271	2	,	,	PUNCT
fnp-3801	271	3	by	by	ADP
fnp-3801	271	4	using	use	VERB
fnp-3801	271	5	a	a	DET
fnp-3801	271	6	high	high	ADJ
fnp-3801	271	7	-	-	PUNCT
fnp-3801	271	8	resolution	resolution	NOUN
fnp-3801	271	9	step	step	NOUN
fnp-3801	271	10	gradient	gradient	NOUN
fnp-3801	271	11	,	,	PUNCT
fnp-3801	271	12	the	the	DET
fnp-3801	271	13	authors	author	NOUN
fnp-3801	271	14	purified	purify	VERB
fnp-3801	271	15	different	different	ADJ
fnp-3801	271	16	ev	ev	ADP
fnp-3801	271	17	fractions	fraction	NOUN
fnp-3801	271	18	from	from	ADP
fnp-3801	271	19	mouse	mouse	NOUN
fnp-3801	271	20	brains	brain	NOUN
fnp-3801	271	21	and	and	CCONJ
fnp-3801	271	22	demonstrated	demonstrate	VERB
fnp-3801	271	23	that	that	SCONJ
fnp-3801	271	24	the	the	DET
fnp-3801	271	25	content	content	NOUN
fnp-3801	271	26	and	and	CCONJ
fnp-3801	271	27	composition	composition	NOUN
fnp-3801	271	28	of	of	ADP
fnp-3801	271	29	evs	evs	NOUN
fnp-3801	271	30	was	be	AUX
fnp-3801	271	31	different	different	ADJ
fnp-3801	271	32	between	between	ADP
fnp-3801	271	33	the	the	DET
fnp-3801	271	34	isolated	isolated	ADJ
fnp-3801	271	35	fractions	fraction	NOUN
fnp-3801	271	36	.	.	PUNCT
fnp-3801	272	1	using	use	VERB
fnp-3801	272	2	cryogenic	cryogenic	NOUN
fnp-3801	272	3	electron	electron	NOUN
fnp-3801	272	4	microscopy	microscopy	NOUN
fnp-3801	272	5	,	,	PUNCT
fnp-3801	272	6	they	they	PRON
fnp-3801	272	7	identified	identify	VERB
fnp-3801	272	8	three	three	NUM
fnp-3801	272	9	brain	brain	NOUN
fnp-3801	272	10	ev	ev	ADP
fnp-3801	272	11	subtypes	subtype	NOUN
fnp-3801	272	12	based	base	VERB
fnp-3801	272	13	on	on	ADP
fnp-3801	272	14	protein	protein	NOUN
fnp-3801	272	15	content	content	NOUN
fnp-3801	272	16	,	,	PUNCT
fnp-3801	272	17	morphology	morphology	NOUN
fnp-3801	272	18	,	,	PUNCT
fnp-3801	272	19	electron	electron	NOUN
fnp-3801	272	20	density	density	NOUN
fnp-3801	272	21	and	and	CCONJ
fnp-3801	272	22	size	size	NOUN
fnp-3801	272	23	.	.	PUNCT
fnp-3801	273	1	then	then	ADV
fnp-3801	273	2	,	,	PUNCT
fnp-3801	273	3	they	they	PRON
fnp-3801	273	4	analyzed	analyze	VERB
fnp-3801	273	5	the	the	DET
fnp-3801	273	6	protein	protein	NOUN
fnp-3801	273	7	composition	composition	NOUN
fnp-3801	273	8	of	of	ADP
fnp-3801	273	9	these	these	DET
fnp-3801	273	10	different	different	ADJ
fnp-3801	273	11	fractions	fraction	NOUN
fnp-3801	273	12	,	,	PUNCT
fnp-3801	273	13	and	and	CCONJ
fnp-3801	273	14	identified	identify	VERB
fnp-3801	273	15	a	a	DET
fnp-3801	273	16	new	new	ADJ
fnp-3801	273	17	class	class	NOUN
fnp-3801	273	18	of	of	ADP
fnp-3801	273	19	vesicles	vesicle	NOUN
fnp-3801	273	20	with	with	ADP
fnp-3801	273	21	high	high	ADJ
fnp-3801	273	22	abundance	abundance	NOUN
fnp-3801	273	23	in	in	ADP
fnp-3801	273	24	mitochondrial	mitochondrial	ADJ
fnp-3801	273	25	markers	marker	NOUN
fnp-3801	273	26	,	,	PUNCT
fnp-3801	273	27	“	"	PUNCT
fnp-3801	273	28	mitovesicles	mitovesicle	NOUN
fnp-3801	273	29	”	"	PUNCT
fnp-3801	273	30	,	,	PUNCT
fnp-3801	273	31	of	of	ADP
fnp-3801	273	32	mitochondrial	mitochondrial	ADJ
fnp-3801	273	33	origin	origin	NOUN
fnp-3801	273	34	.	.	PUNCT
fnp-3801	274	1	using	use	VERB
fnp-3801	274	2	liquid	liquid	ADJ
fnp-3801	274	3	chromatography	chromatography	NOUN
fnp-3801	274	4	-	-	PUNCT
fnp-3801	274	5	mass	mass	NOUN
fnp-3801	274	6	spectrometry	spectrometry	NOUN
fnp-3801	274	7	(	(	PUNCT
fnp-3801	274	8	lc	lc	PROPN
fnp-3801	274	9	-	-	PUNCT
fnp-3801	274	10	ms	ms	NOUN
fnp-3801	274	11	)	)	PUNCT
fnp-3801	274	12	on	on	ADP
fnp-3801	274	13	the	the	DET
fnp-3801	274	14	fraction	fraction	NOUN
fnp-3801	274	15	enriched	enrich	VERB
fnp-3801	274	16	with	with	ADP
fnp-3801	274	17	mitovesicles	mitovesicle	NOUN
fnp-3801	274	18	,	,	PUNCT
fnp-3801	274	19	the	the	DET
fnp-3801	274	20	authors	author	NOUN
fnp-3801	274	21	provide	provide	VERB
fnp-3801	274	22	data	datum	NOUN
fnp-3801	274	23	about	about	ADP
fnp-3801	274	24	their	their	PRON
fnp-3801	274	25	protein	protein	NOUN
fnp-3801	274	26	composition	composition	NOUN
fnp-3801	274	27	,	,	PUNCT
fnp-3801	274	28	with	with	ADP
fnp-3801	274	29	279	279	NUM
fnp-3801	274	30	mitochondria	mitochondria	NOUN
fnp-3801	274	31	-	-	PUNCT
fnp-3801	274	32	specific	specific	ADJ
fnp-3801	274	33	proteins	protein	NOUN
fnp-3801	274	34	of	of	ADP
fnp-3801	274	35	673	673	NUM
fnp-3801	274	36	proteins	protein	NOUN
fnp-3801	274	37	identified	identify	VERB
fnp-3801	274	38	in	in	ADP
fnp-3801	274	39	this	this	DET
fnp-3801	274	40	fraction	fraction	NOUN
fnp-3801	274	41	.	.	PUNCT
fnp-3801	275	1	alterations	alteration	NOUN
fnp-3801	275	2	in	in	ADP
fnp-3801	275	3	mitochondria	mitochondria	PROPN
fnp-3801	275	4	,	,	PUNCT
fnp-3801	275	5	from	from	ADP
fnp-3801	275	6	the	the	DET
fnp-3801	275	7	fetal	fetal	NOUN
fnp-3801	275	8	to	to	ADP
fnp-3801	275	9	the	the	DET
fnp-3801	275	10	adult	adult	NOUN
fnp-3801	275	11	stage	stage	NOUN
fnp-3801	275	12	,	,	PUNCT
fnp-3801	275	13	are	be	AUX
fnp-3801	275	14	a	a	DET
fnp-3801	275	15	pathological	pathological	ADJ
fnp-3801	275	16	signature	signature	NOUN
fnp-3801	275	17	of	of	ADP
fnp-3801	275	18	patients	patient	NOUN
fnp-3801	275	19	with	with	ADP
fnp-3801	275	20	down	down	ADP
fnp-3801	275	21	syndrome	syndrome	NOUN
fnp-3801	275	22	(	(	PUNCT
fnp-3801	275	23	ds	ds	PROPN
fnp-3801	275	24	)	)	PUNCT
fnp-3801	276	1	[	[	X
fnp-3801	276	2	79	79	NUM
fnp-3801	276	3	]	]	PUNCT
fnp-3801	276	4	.	.	PUNCT
fnp-3801	277	1	the	the	DET
fnp-3801	277	2	authors	author	NOUN
fnp-3801	277	3	hypothesized	hypothesize	VERB
fnp-3801	277	4	that	that	SCONJ
fnp-3801	277	5	the	the	DET
fnp-3801	277	6	newly	newly	ADV
fnp-3801	277	7	described	describe	VERB
fnp-3801	277	8	mitovesicles	mitovesicle	NOUN
fnp-3801	277	9	were	be	AUX
fnp-3801	277	10	aberrant	aberrant	ADJ
fnp-3801	277	11	in	in	ADP
fnp-3801	277	12	ds	ds	PROPN
fnp-3801	277	13	.	.	PUNCT
fnp-3801	278	1	in	in	ADP
fnp-3801	278	2	a	a	DET
fnp-3801	278	3	trisomic	trisomic	ADJ
fnp-3801	278	4	mouse	mouse	NOUN
fnp-3801	278	5	model	model	NOUN
fnp-3801	278	6	of	of	ADP
fnp-3801	278	7	ds	ds	PROPN
fnp-3801	278	8	,	,	PUNCT
fnp-3801	278	9	ts[rb(12.17)]2cje	ts[rb(12.17)]2cje	PROPN
fnp-3801	278	10	(	(	PUNCT
fnp-3801	278	11	ts2	ts2	PROPN
fnp-3801	278	12	)	)	PUNCT
fnp-3801	278	13	,	,	PUNCT
fnp-3801	278	14	the	the	DET
fnp-3801	278	15	authors	author	NOUN
fnp-3801	278	16	found	find	VERB
fnp-3801	278	17	alterations	alteration	NOUN
fnp-3801	278	18	in	in	ADP
fnp-3801	278	19	mitochondrial	mitochondrial	ADJ
fnp-3801	278	20	proteins	protein	NOUN
fnp-3801	278	21	in	in	ADP
fnp-3801	278	22	ev	ev	ADP
fnp-3801	278	23	fractions	fraction	NOUN
fnp-3801	278	24	and	and	CCONJ
fnp-3801	278	25	a	a	DET
fnp-3801	278	26	higher	high	ADJ
fnp-3801	278	27	number	number	NOUN
fnp-3801	278	28	of	of	ADP
fnp-3801	278	29	mitovesicles	mitovesicle	NOUN
fnp-3801	278	30	in	in	ADP
fnp-3801	278	31	the	the	DET
fnp-3801	278	32	parenchyma	parenchyma	NOUN
fnp-3801	278	33	.	.	PUNCT
fnp-3801	279	1	they	they	PRON
fnp-3801	279	2	replicated	replicate	VERB
fnp-3801	279	3	these	these	DET
fnp-3801	279	4	results	result	NOUN
fnp-3801	279	5	in	in	ADP
fnp-3801	279	6	humans	human	NOUN
fnp-3801	279	7	using	use	VERB
fnp-3801	279	8	post	post	NOUN
fnp-3801	279	9	mortem	mortem	X
fnp-3801	279	10	brains	brain	NOUN
fnp-3801	279	11	of	of	ADP
fnp-3801	279	12	individuals	individual	NOUN
fnp-3801	279	13	with	with	ADP
fnp-3801	279	14	ds	ds	PROPN
fnp-3801	279	15	.	.	PUNCT
fnp-3801	280	1	although	although	SCONJ
fnp-3801	280	2	the	the	DET
fnp-3801	280	3	pathogenic	pathogenic	ADJ
fnp-3801	280	4	role	role	NOUN
fnp-3801	280	5	of	of	ADP
fnp-3801	280	6	these	these	DET
fnp-3801	280	7	alterations	alteration	NOUN
fnp-3801	280	8	in	in	ADP
fnp-3801	280	9	number	number	NOUN
fnp-3801	280	10	and	and	CCONJ
fnp-3801	280	11	in	in	ADP
fnp-3801	280	12	protein	protein	NOUN
fnp-3801	280	13	composition	composition	NOUN
fnp-3801	280	14	of	of	ADP
fnp-3801	280	15	mitovesicles	mitovesicle	NOUN
fnp-3801	280	16	remains	remain	VERB
fnp-3801	280	17	unknown	unknown	ADJ
fnp-3801	280	18	,	,	PUNCT
fnp-3801	280	19	ds	ds	ADJ
fnp-3801	280	20	cells	cell	NOUN
fnp-3801	280	21	are	be	AUX
fnp-3801	280	22	deficient	deficient	ADJ
fnp-3801	280	23	in	in	ADP
fnp-3801	280	24	the	the	DET
fnp-3801	280	25	elimination	elimination	NOUN
fnp-3801	280	26	of	of	ADP
fnp-3801	280	27	mitochondria	mitochondria	NOUN
fnp-3801	280	28	,	,	PUNCT
fnp-3801	280	29	a	a	DET
fnp-3801	280	30	process	process	NOUN
fnp-3801	280	31	called	call	VERB
fnp-3801	280	32	mitophagy	mitophagy	NOUN
fnp-3801	280	33	,	,	PUNCT
fnp-3801	280	34	and	and	CCONJ
fnp-3801	280	35	thus	thus	ADV
fnp-3801	280	36	,	,	PUNCT
fnp-3801	280	37	the	the	DET
fnp-3801	280	38	excess	excess	NOUN
fnp-3801	280	39	of	of	ADP
fnp-3801	280	40	mitovesicles	mitovesicle	NOUN
fnp-3801	280	41	could	could	AUX
fnp-3801	280	42	contribute	contribute	VERB
fnp-3801	280	43	to	to	ADP
fnp-3801	280	44	the	the	DET
fnp-3801	280	45	removal	removal	NOUN
fnp-3801	280	46	of	of	ADP
fnp-3801	280	47	damaged	damage	VERB
fnp-3801	280	48	mitochondria	mitochondria	NOUN
fnp-3801	280	49	,	,	PUNCT
fnp-3801	280	50	working	work	VERB
fnp-3801	280	51	as	as	ADP
fnp-3801	280	52	a	a	DET
fnp-3801	280	53	homeostatic	homeostatic	ADJ
fnp-3801	280	54	process	process	NOUN
fnp-3801	280	55	to	to	PART
fnp-3801	280	56	reduce	reduce	VERB
fnp-3801	280	57	cellular	cellular	ADJ
fnp-3801	280	58	stress	stress	NOUN
fnp-3801	280	59	.	.	PUNCT
fnp-3801	281	1	another	another	DET
fnp-3801	281	2	possibility	possibility	NOUN
fnp-3801	281	3	is	be	AUX
fnp-3801	281	4	that	that	SCONJ
fnp-3801	281	5	mitovesicles	mitovesicle	NOUN
fnp-3801	281	6	may	may	AUX
fnp-3801	281	7	activate	activate	VERB
fnp-3801	281	8	microglia	microglia	NOUN
fnp-3801	281	9	through	through	ADP
fnp-3801	281	10	acting	act	VERB
fnp-3801	281	11	as	as	ADP
fnp-3801	281	12	proinflammatory	proinflammatory	ADJ
fnp-3801	281	13	agents	agent	NOUN
fnp-3801	281	14	,	,	PUNCT
fnp-3801	281	15	which	which	PRON
fnp-3801	281	16	would	would	AUX
fnp-3801	281	17	explain	explain	VERB
fnp-3801	281	18	the	the	DET
fnp-3801	281	19	over	over	ADV
fnp-3801	281	20	-	-	PUNCT
fnp-3801	281	21	activated	activate	VERB
fnp-3801	281	22	microglia	microglia	NOUN
fnp-3801	281	23	detected	detect	VERB
fnp-3801	281	24	in	in	ADP
fnp-3801	281	25	several	several	ADJ
fnp-3801	281	26	ds	ds	ADJ
fnp-3801	281	27	mouse	mouse	NOUN
fnp-3801	281	28	models	model	NOUN
fnp-3801	281	29	[	[	X
fnp-3801	281	30	80	80	NUM
fnp-3801	281	31	]	]	PUNCT
fnp-3801	281	32	.	.	PUNCT
fnp-3801	282	1	this	this	DET
fnp-3801	282	2	study	study	NOUN
fnp-3801	282	3	describes	describe	VERB
fnp-3801	282	4	and	and	CCONJ
fnp-3801	282	5	characterizes	characterize	VERB
fnp-3801	282	6	for	for	ADP
fnp-3801	282	7	the	the	DET
fnp-3801	282	8	first	first	ADJ
fnp-3801	282	9	time	time	NOUN
fnp-3801	282	10	a	a	DET
fnp-3801	282	11	new	new	ADJ
fnp-3801	282	12	type	type	NOUN
fnp-3801	282	13	of	of	ADP
fnp-3801	282	14	ev	ev	NOUN
fnp-3801	282	15	derived	derive	VERB
fnp-3801	282	16	from	from	ADP
fnp-3801	282	17	mitochondria	mitochondria	NOUN
fnp-3801	282	18	and	and	CCONJ
fnp-3801	282	19	also	also	ADV
fnp-3801	282	20	describes	describe	VERB
fnp-3801	282	21	a	a	DET
fnp-3801	282	22	potential	potential	ADJ
fnp-3801	282	23	role	role	NOUN
fnp-3801	282	24	in	in	ADP
fnp-3801	282	25	an	an	DET
fnp-3801	282	26	ndd	ndd	NOUN
fnp-3801	282	27	such	such	ADJ
fnp-3801	282	28	as	as	ADP
fnp-3801	282	29	ds	ds	PROPN
fnp-3801	282	30	.	.	NOUN
fnp-3801	282	31	discussion	discussion	NOUN
fnp-3801	282	32	the	the	DET
fnp-3801	282	33	complexity	complexity	NOUN
fnp-3801	282	34	and	and	CCONJ
fnp-3801	282	35	heterogeneity	heterogeneity	NOUN
fnp-3801	282	36	of	of	ADP
fnp-3801	282	37	the	the	DET
fnp-3801	282	38	myriad	myriad	NOUN
fnp-3801	282	39	of	of	ADP
fnp-3801	282	40	ndds	ndd	NOUN
fnp-3801	282	41	makes	make	VERB
fnp-3801	282	42	it	it	PRON
fnp-3801	282	43	difficult	difficult	ADJ
fnp-3801	282	44	to	to	PART
fnp-3801	282	45	decipher	decipher	VERB
fnp-3801	282	46	the	the	DET
fnp-3801	282	47	ultimate	ultimate	ADJ
fnp-3801	282	48	mechanisms	mechanism	NOUN
fnp-3801	282	49	of	of	ADP
fnp-3801	282	50	ndd	ndd	PROPN
fnp-3801	282	51	neuropathology	neuropathology	NOUN
fnp-3801	282	52	.	.	PUNCT
fnp-3801	283	1	accumulating	accumulate	VERB
fnp-3801	283	2	evidence	evidence	NOUN
fnp-3801	283	3	suggests	suggest	VERB
fnp-3801	283	4	that	that	SCONJ
fnp-3801	283	5	their	their	PRON
fnp-3801	283	6	multidimensional	multidimensional	ADJ
fnp-3801	283	7	nature	nature	NOUN
fnp-3801	283	8	can	can	AUX
fnp-3801	283	9	be	be	AUX
fnp-3801	283	10	explained	explain	VERB
fnp-3801	283	11	by	by	ADP
fnp-3801	283	12	the	the	DET
fnp-3801	283	13	interaction	interaction	NOUN
fnp-3801	283	14	of	of	ADP
fnp-3801	283	15	numerous	numerous	ADJ
fnp-3801	283	16	genetic	genetic	ADJ
fnp-3801	283	17	and	and	CCONJ
fnp-3801	283	18	environmental	environmental	ADJ
fnp-3801	283	19	factors	factor	NOUN
fnp-3801	283	20	.	.	PUNCT
fnp-3801	284	1	luckily	luckily	ADV
fnp-3801	284	2	,	,	PUNCT
fnp-3801	284	3	we	we	PRON
fnp-3801	284	4	are	be	AUX
fnp-3801	284	5	now	now	ADV
fnp-3801	284	6	facing	face	VERB
fnp-3801	284	7	exciting	exciting	ADJ
fnp-3801	284	8	times	time	NOUN
fnp-3801	284	9	in	in	ADP
fnp-3801	284	10	which	which	PRON
fnp-3801	284	11	we	we	PRON
fnp-3801	284	12	can	can	AUX
fnp-3801	284	13	study	study	VERB
fnp-3801	284	14	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	284	15	disorder	disorder	NOUN
fnp-3801	284	16	from	from	ADP
fnp-3801	284	17	a	a	DET
fnp-3801	284	18	holistic	holistic	ADJ
fnp-3801	284	19	perspective	perspective	NOUN
fnp-3801	284	20	using	use	VERB
fnp-3801	284	21	advanced	advanced	ADJ
fnp-3801	284	22	omics	omic	NOUN
fnp-3801	284	23	and	and	CCONJ
fnp-3801	284	24	cell	cell	NOUN
fnp-3801	284	25	engineering	engineering	NOUN
fnp-3801	284	26	techniques	technique	NOUN
fnp-3801	284	27	that	that	PRON
fnp-3801	284	28	are	be	AUX
fnp-3801	284	29	increasing	increase	VERB
fnp-3801	284	30	the	the	DET
fnp-3801	284	31	temporo	temporo	NOUN
fnp-3801	284	32	-	-	PUNCT
fnp-3801	284	33	spatial	spatial	ADJ
fnp-3801	284	34	resolution	resolution	NOUN
fnp-3801	284	35	of	of	ADP
fnp-3801	284	36	our	our	PRON
fnp-3801	284	37	mechanistic	mechanistic	ADJ
fnp-3801	284	38	understanding	understanding	NOUN
fnp-3801	284	39	.	.	PUNCT
fnp-3801	285	1	techniques	technique	NOUN
fnp-3801	285	2	such	such	ADJ
fnp-3801	285	3	as	as	ADP
fnp-3801	285	4	single	single	ADJ
fnp-3801	285	5	cell	cell	NOUN
fnp-3801	285	6	omics	omic	NOUN
fnp-3801	285	7	or	or	CCONJ
fnp-3801	285	8	spatial	spatial	ADJ
fnp-3801	285	9	transcriptomics	transcriptomic	NOUN
fnp-3801	285	10	and	and	CCONJ
fnp-3801	285	11	proteomics	proteomic	NOUN
fnp-3801	285	12	help	help	VERB
fnp-3801	285	13	us	we	PRON
fnp-3801	285	14	to	to	PART
fnp-3801	285	15	unravel	unravel	VERB
fnp-3801	285	16	the	the	DET
fnp-3801	285	17	enormous	enormous	ADJ
fnp-3801	285	18	diversity	diversity	NOUN
fnp-3801	285	19	and	and	CCONJ
fnp-3801	285	20	complexity	complexity	NOUN
fnp-3801	285	21	of	of	ADP
fnp-3801	285	22	both	both	DET
fnp-3801	285	23	cell	cell	NOUN
fnp-3801	285	24	composition	composition	NOUN
fnp-3801	285	25	and	and	CCONJ
fnp-3801	285	26	cell	cell	NOUN
fnp-3801	285	27	type	type	NOUN
fnp-3801	285	28	-	-	PUNCT
fnp-3801	285	29	specific	specific	ADJ
fnp-3801	285	30	molecular	molecular	ADJ
fnp-3801	285	31	signatures	signature	NOUN
fnp-3801	285	32	throughout	throughout	ADP
fnp-3801	285	33	the	the	DET
fnp-3801	285	34	brain	brain	NOUN
fnp-3801	285	35	.	.	PUNCT
fnp-3801	286	1	the	the	DET
fnp-3801	286	2	number	number	NOUN
fnp-3801	286	3	of	of	ADP
fnp-3801	286	4	publications	publication	NOUN
fnp-3801	286	5	associating	associate	VERB
fnp-3801	286	6	new	new	ADJ
fnp-3801	286	7	cellular	cellular	ADJ
fnp-3801	286	8	players	player	NOUN
fnp-3801	286	9	such	such	ADJ
fnp-3801	286	10	as	as	ADP
fnp-3801	286	11	the	the	DET
fnp-3801	286	12	astrocytes	astrocyte	NOUN
fnp-3801	286	13	with	with	ADP
fnp-3801	286	14	brain	brain	NOUN
fnp-3801	286	15	alterations	alteration	NOUN
fnp-3801	286	16	have	have	AUX
fnp-3801	286	17	increased	increase	VERB
fnp-3801	286	18	exponentially	exponentially	ADV
fnp-3801	286	19	in	in	ADP
fnp-3801	286	20	the	the	DET
fnp-3801	286	21	last	last	ADJ
fnp-3801	286	22	three	three	NUM
fnp-3801	286	23	decades	decade	NOUN
fnp-3801	286	24	suggesting	suggest	VERB
fnp-3801	286	25	an	an	DET
fnp-3801	286	26	important	important	ADJ
fnp-3801	286	27	role	role	NOUN
fnp-3801	286	28	of	of	ADP
fnp-3801	286	29	this	this	DET
fnp-3801	286	30	cell	cell	NOUN
fnp-3801	286	31	type	type	NOUN
fnp-3801	286	32	in	in	ADP
fnp-3801	286	33	the	the	DET
fnp-3801	286	34	onset	onset	NOUN
fnp-3801	286	35	and	and	CCONJ
fnp-3801	286	36	progression	progression	NOUN
fnp-3801	286	37	of	of	ADP
fnp-3801	286	38	several	several	ADJ
fnp-3801	286	39	ndds	ndd	NOUN
fnp-3801	286	40	.	.	PUNCT
fnp-3801	287	1	every	every	DET
fnp-3801	287	2	year	year	NOUN
fnp-3801	287	3	,	,	PUNCT
fnp-3801	287	4	selected	select	VERB
fnp-3801	287	5	discoveries	discovery	NOUN
fnp-3801	287	6	open	open	VERB
fnp-3801	287	7	new	new	ADJ
fnp-3801	287	8	avenues	avenue	NOUN
fnp-3801	287	9	to	to	PART
fnp-3801	287	10	investigate	investigate	VERB
fnp-3801	287	11	ndds	ndd	NOUN
fnp-3801	287	12	from	from	ADP
fnp-3801	287	13	completely	completely	ADV
fnp-3801	287	14	unexplored	unexplored	ADJ
fnp-3801	287	15	perspectives	perspective	NOUN
fnp-3801	287	16	and	and	CCONJ
fnp-3801	287	17	serve	serve	VERB
fnp-3801	287	18	as	as	ADP
fnp-3801	287	19	building	build	VERB
fnp-3801	287	20	blocks	block	NOUN
fnp-3801	287	21	to	to	PART
fnp-3801	287	22	better	well	ADV
fnp-3801	287	23	comprehend	comprehend	VERB
fnp-3801	287	24	the	the	DET
fnp-3801	287	25	enormous	enormous	ADJ
fnp-3801	287	26	complexity	complexity	NOUN
fnp-3801	287	27	of	of	ADP
fnp-3801	287	28	ndds	ndd	NOUN
fnp-3801	287	29	,	,	PUNCT
fnp-3801	287	30	hopefully	hopefully	ADV
fnp-3801	287	31	leading	lead	VERB
fnp-3801	287	32	to	to	ADP
fnp-3801	287	33	better	well	ADJ
fnp-3801	287	34	diagnostics	diagnostic	NOUN
fnp-3801	287	35	and	and	CCONJ
fnp-3801	287	36	new	new	ADJ
fnp-3801	287	37	therapeutic	therapeutic	ADJ
fnp-3801	287	38	avenues	avenue	NOUN
fnp-3801	287	39	.	.	PUNCT
fnp-3801	288	1	acknowledgements	acknowledgement	NOUN
fnp-3801	288	2	the	the	DET
fnp-3801	288	3	lab	lab	NOUN
fnp-3801	288	4	of	of	ADP
fnp-3801	288	5	md	md	PROPN
fnp-3801	288	6	is	be	AUX
fnp-3801	288	7	supported	support	VERB
fnp-3801	288	8	by	by	ADP
fnp-3801	288	9	the	the	DET
fnp-3801	288	10	secretaria	secretaria	PROPN
fnp-3801	288	11	d’universitats	d’universitats	PROPN
fnp-3801	288	12	i	i	PRON
fnp-3801	288	13	recerca	recerca	VERB
fnp-3801	288	14	del	del	ADV
fnp-3801	288	15	departament	departament	NOUN
fnp-3801	289	1	d’economia	d’economia	ADV
fnp-3801	289	2	i	i	PRON
fnp-3801	289	3	coneixement	coneixement	ADJ
fnp-3801	289	4	de	de	X
fnp-3801	289	5	la	la	X
fnp-3801	289	6	generalitat	generalitat	PROPN
fnp-3801	289	7	de	de	PROPN
fnp-3801	289	8	catalunya	catalunya	PROPN
fnp-3801	289	9	(	(	PUNCT
fnp-3801	289	10	grups	grup	NOUN
fnp-3801	289	11	consolidats	consolidat	VERB
fnp-3801	289	12	2017	2017	NUM
fnp-3801	289	13	sgr	sgr	PROPN
fnp-3801	289	14	926	926	NUM
fnp-3801	289	15	)	)	PUNCT
fnp-3801	289	16	.	.	PUNCT
fnp-3801	290	1	we	we	PRON
fnp-3801	290	2	also	also	ADV
fnp-3801	290	3	acknowledge	acknowledge	VERB
fnp-3801	290	4	the	the	DET
fnp-3801	290	5	support	support	NOUN
fnp-3801	290	6	of	of	ADP
fnp-3801	290	7	the	the	DET
fnp-3801	290	8	agencia	agencia	PROPN
fnp-3801	290	9	estatal	estatal	PROPN
fnp-3801	290	10	de	de	PROPN
fnp-3801	290	11	investigación	investigación	PROPN
fnp-3801	290	12	(	(	PUNCT
fnp-3801	290	13	pid2019	pid2019	NOUN
fnp-3801	290	14	-	-	PUNCT
fnp-3801	290	15	110755rb	110755rb	NOUN
fnp-3801	290	16	-	-	PUNCT
fnp-3801	290	17	i00	i00	NOUN
fnp-3801	290	18	/	/	SYM
fnp-3801	290	19	aei	aei	PROPN
fnp-3801	290	20	/	/	SYM
fnp-3801	290	21	10.13039/501100011033	10.13039/501100011033	NUM
fnp-3801	290	22	)	)	PUNCT
fnp-3801	290	23	,	,	PUNCT
fnp-3801	290	24	h2020	h2020	VERB
fnp-3801	290	25	sc1	sc1	PROPN
fnp-3801	290	26	go	go	VERB
fnp-3801	290	27	-	-	PUNCT
fnp-3801	290	28	ds21	ds21	PROPN
fnp-3801	290	29	-	-	PUNCT
fnp-3801	290	30	848077	848077	NUM
fnp-3801	290	31	and	and	CCONJ
fnp-3801	290	32	101057454	101057454	NUM
fnp-3801	290	33	-	-	PUNCT
fnp-3801	290	34	psych	psych	NOUN
fnp-3801	290	35	-	-	PUNCT
fnp-3801	290	36	strata	strata	NOUN
fnp-3801	290	37	,	,	PUNCT
fnp-3801	290	38	jerôme	jerôme	PROPN
fnp-3801	290	39	lejeune	lejeune	PROPN
fnp-3801	290	40	foundation	foundation	PROPN
fnp-3801	290	41	#	#	SYM
fnp-3801	290	42	2002	2002	NUM
fnp-3801	290	43	,	,	PUNCT
fnp-3801	290	44	nih	nih	PROPN
fnp-3801	290	45	(	(	PUNCT
fnp-3801	290	46	grant	grant	PROPN
fnp-3801	290	47	number	number	NOUN
fnp-3801	290	48	:	:	PUNCT
fnp-3801	290	49	1r01eb	1r01eb	NUM
fnp-3801	290	50	028159	028159	NUM
fnp-3801	290	51	-	-	SYM
fnp-3801	290	52	01	01	NUM
fnp-3801	290	53	)	)	PUNCT
fnp-3801	290	54	,	,	PUNCT
fnp-3801	290	55	fundació	fundació	PROPN
fnp-3801	290	56	la	la	PROPN
fnp-3801	290	57	marató	marató	PROPN
fnp-3801	290	58	-	-	PUNCT
fnp-3801	290	59	tv3	tv3	PROPN
fnp-3801	290	60	(	(	PUNCT
fnp-3801	290	61	#	#	SYM
fnp-3801	290	62	2016/20	2016/20	NUM
fnp-3801	290	63	-	-	SYM
fnp-3801	290	64	30	30	NUM
fnp-3801	290	65	)	)	PUNCT
fnp-3801	290	66	,	,	PUNCT
fnp-3801	290	67	ministerio	ministerio	PROPN
fnp-3801	290	68	de	de	PROPN
fnp-3801	290	69	ciencia	ciencia	PROPN
fnp-3801	290	70	innovación	innovación	PROPN
fnp-3801	290	71	y	y	PROPN
fnp-3801	290	72	universidades	universidades	PROPN
fnp-3801	290	73	(	(	PUNCT
fnp-3801	290	74	rtc2019	rtc2019	NOUN
fnp-3801	290	75	-	-	PUNCT
fnp-3801	290	76	007230	007230	NUM
fnp-3801	290	77	-	-	PUNCT
fnp-3801	290	78	1	1	NUM
fnp-3801	290	79	and	and	CCONJ
fnp-3801	290	80	rtc2019	rtc2019	NOUN
fnp-3801	290	81	-	-	PUNCT
fnp-3801	290	82	007329	007329	NUM
fnp-3801	290	83	-	-	PUNCT
fnp-3801	290	84	1	1	NUM
fnp-3801	290	85	)	)	PUNCT
fnp-3801	290	86	.	.	PUNCT
fnp-3801	291	1	cs	cs	PROPN
fnp-3801	291	2	received	receive	VERB
fnp-3801	291	3	an	an	DET
fnp-3801	291	4	fi	fi	NOUN
fnp-3801	291	5	grant	grant	NOUN
fnp-3801	291	6	(	(	PUNCT
fnp-3801	291	7	2020fi_b2	2020fi_b2	NUM
fnp-3801	291	8	00143	00143	NUM
fnp-3801	291	9	)	)	PUNCT
fnp-3801	291	10	from	from	ADP
fnp-3801	291	11	the	the	DET
fnp-3801	291	12	agència	agència	PROPN
fnp-3801	291	13	de	de	X
fnp-3801	291	14	gestió	gestió	PROPN
fnp-3801	291	15	d’ajuts	d’ajut	NOUN
fnp-3801	291	16	universitaris	universitaris	NOUN
fnp-3801	291	17	i	i	PROPN
fnp-3801	291	18	de	de	PROPN
fnp-3801	291	19	recerca	recerca	PROPN
fnp-3801	291	20	(	(	PUNCT
fnp-3801	291	21	agaur	agaur	NOUN
fnp-3801	291	22	)	)	PUNCT
fnp-3801	291	23	de	de	X
fnp-3801	291	24	la	la	X
fnp-3801	291	25	generalitat	generalitat	PROPN
fnp-3801	291	26	de	de	PROPN
fnp-3801	291	27	catalunya	catalunya	PROPN
fnp-3801	291	28	;	;	PUNCT
fnp-3801	291	29	ms	ms	PROPN
fnp-3801	291	30	received	receive	VERB
fnp-3801	291	31	an	an	DET
fnp-3801	291	32	fpu	fpu	NOUN
fnp-3801	291	33	fellowship	fellowship	NOUN
fnp-3801	291	34	(	(	PUNCT
fnp-3801	291	35	fpu19/04789	fpu19/04789	NOUN
fnp-3801	291	36	)	)	PUNCT
fnp-3801	291	37	and	and	CCONJ
fnp-3801	291	38	afb	afb	PROPN
fnp-3801	291	39	received	receive	VERB
fnp-3801	291	40	an	an	DET
fnp-3801	291	41	fpi	fpi	PROPN
fnp-3801	291	42	-	-	PUNCT
fnp-3801	291	43	so	so	PROPN
fnp-3801	291	44	fellowship	fellowship	NOUN
fnp-3801	291	45	(	(	PUNCT
fnp-3801	291	46	pre2018	pre2018	NOUN
fnp-3801	291	47	-	-	PUNCT
fnp-3801	291	48	084504	084504	NUM
fnp-3801	291	49	)	)	PUNCT
fnp-3801	291	50	of	of	ADP
fnp-3801	291	51	the	the	DET
fnp-3801	291	52	ministerio	ministerio	PROPN
fnp-3801	291	53	de	de	PROPN
fnp-3801	291	54	universidades	universidades	PROPN
fnp-3801	291	55	,	,	PUNCT
fnp-3801	291	56	spain	spain	PROPN
fnp-3801	291	57	.	.	PUNCT
fnp-3801	292	1	we	we	PRON
fnp-3801	292	2	acknowledge	acknowledge	VERB
fnp-3801	292	3	support	support	NOUN
fnp-3801	292	4	of	of	ADP
fnp-3801	292	5	the	the	DET
fnp-3801	292	6	spanish	spanish	PROPN
fnp-3801	292	7	ministry	ministry	PROPN
fnp-3801	292	8	of	of	ADP
fnp-3801	292	9	science	science	NOUN
fnp-3801	292	10	and	and	CCONJ
fnp-3801	292	11	innovation	innovation	NOUN
fnp-3801	292	12	to	to	ADP
fnp-3801	292	13	the	the	DET
fnp-3801	292	14	embl	embl	PROPN
fnp-3801	292	15	partnership	partnership	PROPN
fnp-3801	292	16	,	,	PUNCT
fnp-3801	292	17	the	the	DET
fnp-3801	292	18	centro	centro	PROPN
fnp-3801	292	19	de	de	X
fnp-3801	292	20	excelencia	excelencia	PROPN
fnp-3801	292	21	severo	severo	PROPN
fnp-3801	292	22	ochoa	ochoa	PROPN
fnp-3801	292	23	and	and	CCONJ
fnp-3801	292	24	the	the	DET
fnp-3801	292	25	cerca	cerca	PROPN
fnp-3801	292	26	programme	programme	PROPN
fnp-3801	292	27	/generalitat	/generalitat	PUNCT
fnp-3801	292	28	de	de	PROPN
fnp-3801	292	29	catalunya	catalunya	PROPN
fnp-3801	292	30	.	.	PUNCT
fnp-3801	293	1	the	the	DET
fnp-3801	293	2	ciber	ciber	NOUN
fnp-3801	293	3	of	of	ADP
fnp-3801	293	4	rare	rare	ADJ
fnp-3801	293	5	diseases	disease	NOUN
fnp-3801	293	6	is	be	AUX
fnp-3801	293	7	an	an	DET
fnp-3801	293	8	initiative	initiative	NOUN
fnp-3801	293	9	of	of	ADP
fnp-3801	293	10	the	the	DET
fnp-3801	293	11	isciii	isciii	PROPN
fnp-3801	293	12	.	.	PUNCT
fnp-3801	294	1	references	reference	NOUN
fnp-3801	294	2	crow	crow	VERB
fnp-3801	294	3	,	,	PUNCT
fnp-3801	294	4	y.j	y.j	PROPN
fnp-3801	294	5	.	.	PROPN
fnp-3801	294	6	and	and	CCONJ
fnp-3801	294	7	n.	n.	PROPN
fnp-3801	294	8	manel	manel	PROPN
fnp-3801	294	9	,	,	PUNCT
fnp-3801	294	10	aicardi	aicardi	NOUN
fnp-3801	294	11	-	-	PUNCT
fnp-3801	294	12	goutieres	goutiere	NOUN
fnp-3801	294	13	syndrome	syndrome	NOUN
fnp-3801	294	14	and	and	CCONJ
fnp-3801	294	15	the	the	DET
fnp-3801	294	16	type	type	NOUN
fnp-3801	294	17	i	i	PRON
fnp-3801	294	18	interferonopathies	interferonopathie	NOUN
fnp-3801	294	19	.	.	PUNCT
fnp-3801	295	1	nat	nat	PROPN
fnp-3801	295	2	rev	rev	PROPN
fnp-3801	295	3	immunol	immunol	NOUN
fnp-3801	295	4	,	,	PUNCT
fnp-3801	295	5	2015	2015	NUM
fnp-3801	295	6	.	.	PUNCT
fnp-3801	296	1	15(7	15(7	NUM
fnp-3801	296	2	):	):	PUNCT
fnp-3801	297	1	p.	p.	NOUN
fnp-3801	297	2	429	429	NUM
fnp-3801	297	3	-	-	SYM
fnp-3801	297	4	40	40	NUM
fnp-3801	297	5	.	.	PUNCT
fnp-3801	298	1	crow	crow	PROPN
fnp-3801	298	2	,	,	PUNCT
fnp-3801	298	3	y.j	y.j	PROPN
fnp-3801	298	4	.	.	PROPN
fnp-3801	298	5	,	,	PUNCT
fnp-3801	298	6	et	et	PROPN
fnp-3801	298	7	al	al	PROPN
fnp-3801	298	8	.	.	PROPN
fnp-3801	298	9	,	,	PUNCT
fnp-3801	298	10	characterization	characterization	NOUN
fnp-3801	298	11	of	of	ADP
fnp-3801	298	12	human	human	ADJ
fnp-3801	298	13	disease	disease	NOUN
fnp-3801	298	14	phenotypes	phenotype	NOUN
fnp-3801	298	15	associated	associate	VERB
fnp-3801	298	16	with	with	ADP
fnp-3801	298	17	mutations	mutation	NOUN
fnp-3801	298	18	in	in	ADP
fnp-3801	298	19	trex1	trex1	NOUN
fnp-3801	298	20	,	,	PUNCT
fnp-3801	298	21	rnaseh2a	rnaseh2a	PROPN
fnp-3801	298	22	,	,	PUNCT
fnp-3801	298	23	rnaseh2b	rnaseh2b	PROPN
fnp-3801	298	24	,	,	PUNCT
fnp-3801	298	25	rnaseh2c	rnaseh2c	PROPN
fnp-3801	298	26	,	,	PUNCT
fnp-3801	298	27	samhd1	samhd1	PROPN
fnp-3801	298	28	,	,	PUNCT
fnp-3801	298	29	adar	adar	PROPN
fnp-3801	298	30	,	,	PUNCT
fnp-3801	298	31	and	and	CCONJ
fnp-3801	298	32	ifih1	ifih1	NOUN
fnp-3801	298	33	.	.	PUNCT
fnp-3801	298	34	am	be	AUX
fnp-3801	298	35	j	j	PROPN
fnp-3801	298	36	med	med	PROPN
fnp-3801	298	37	genet	genet	PROPN
fnp-3801	298	38	a	a	PRON
fnp-3801	298	39	,	,	PUNCT
fnp-3801	298	40	2015	2015	NUM
fnp-3801	298	41	.	.	PUNCT
fnp-3801	299	1	167a(2	167a(2	NUM
fnp-3801	299	2	):	):	PUNCT
fnp-3801	299	3	p.	p.	NOUN
fnp-3801	299	4	296	296	NUM
fnp-3801	299	5	-	-	SYM
fnp-3801	299	6	312	312	NUM
fnp-3801	299	7	.	.	PUNCT
fnp-3801	299	8	cuadrado	cuadrado	PROPN
fnp-3801	299	9	,	,	PUNCT
fnp-3801	299	10	e.	e.	PROPN
fnp-3801	299	11	,	,	PUNCT
fnp-3801	299	12	et	et	PROPN
fnp-3801	299	13	al	al	PROPN
fnp-3801	299	14	.	.	PROPN
fnp-3801	299	15	,	,	PUNCT
fnp-3801	299	16	chronic	chronic	ADJ
fnp-3801	299	17	exposure	exposure	NOUN
fnp-3801	299	18	of	of	ADP
fnp-3801	299	19	astrocytes	astrocyte	NOUN
fnp-3801	299	20	to	to	ADP
fnp-3801	299	21	interferon	interferon	ADJ
fnp-3801	299	22	-	-	PUNCT
fnp-3801	299	23	alpha	alpha	NOUN
fnp-3801	299	24	reveals	reveal	VERB
fnp-3801	299	25	molecular	molecular	ADJ
fnp-3801	299	26	changes	change	NOUN
fnp-3801	299	27	related	relate	VERB
fnp-3801	299	28	to	to	ADP
fnp-3801	299	29	aicardi	aicardi	NOUN
fnp-3801	299	30	-	-	PUNCT
fnp-3801	299	31	goutieres	goutiere	NOUN
fnp-3801	299	32	syndrome	syndrome	NOUN
fnp-3801	299	33	.	.	PUNCT
fnp-3801	300	1	brain	brain	NOUN
fnp-3801	300	2	,	,	PUNCT
fnp-3801	300	3	2013	2013	NUM
fnp-3801	300	4	.	.	PUNCT
fnp-3801	301	1	136(pt	136(pt	NUM
fnp-3801	301	2	1	1	NUM
fnp-3801	301	3	):	):	PUNCT
fnp-3801	301	4	p.	p.	NOUN
fnp-3801	301	5	245	245	NUM
fnp-3801	301	6	-	-	SYM
fnp-3801	301	7	58	58	NUM
fnp-3801	301	8	.	.	PUNCT
fnp-3801	302	1	rice	rice	PROPN
fnp-3801	302	2	,	,	PUNCT
fnp-3801	302	3	g.i	g.i	PROPN
fnp-3801	302	4	.	.	PROPN
fnp-3801	302	5	,	,	PUNCT
fnp-3801	302	6	et	et	PROPN
fnp-3801	302	7	al	al	PROPN
fnp-3801	302	8	.	.	PROPN
fnp-3801	302	9	,	,	PUNCT
fnp-3801	302	10	mutations	mutation	NOUN
fnp-3801	302	11	involved	involve	VERB
fnp-3801	302	12	in	in	ADP
fnp-3801	302	13	aicardi	aicardi	NOUN
fnp-3801	302	14	-	-	PUNCT
fnp-3801	302	15	goutieres	goutiere	NOUN
fnp-3801	302	16	syndrome	syndrome	NOUN
fnp-3801	302	17	implicate	implicate	VERB
fnp-3801	302	18	samhd1	samhd1	NOUN
fnp-3801	302	19	as	as	ADP
fnp-3801	302	20	regulator	regulator	NOUN
fnp-3801	302	21	of	of	ADP
fnp-3801	302	22	the	the	DET
fnp-3801	302	23	innate	innate	ADJ
fnp-3801	302	24	immune	immune	ADJ
fnp-3801	302	25	response	response	NOUN
fnp-3801	302	26	.	.	PUNCT
fnp-3801	303	1	nat	nat	PROPN
fnp-3801	303	2	genet	genet	PROPN
fnp-3801	303	3	,	,	PUNCT
fnp-3801	303	4	2009	2009	NUM
fnp-3801	303	5	.	.	PUNCT
fnp-3801	304	1	41(7	41(7	NUM
fnp-3801	304	2	):	):	PUNCT
fnp-3801	305	1	p.	p.	NOUN
fnp-3801	305	2	829	829	NUM
fnp-3801	305	3	-	-	SYM
fnp-3801	305	4	32	32	NUM
fnp-3801	305	5	.	.	PUNCT
fnp-3801	306	1	lee	lee	PROPN
fnp-3801	306	2	-	-	PUNCT
fnp-3801	306	3	kirsch	kirsch	PROPN
fnp-3801	306	4	,	,	PUNCT
fnp-3801	306	5	m.a	m.a	PROPN
fnp-3801	306	6	.	.	PROPN
fnp-3801	306	7	,	,	PUNCT
fnp-3801	306	8	the	the	DET
fnp-3801	306	9	type	type	NOUN
fnp-3801	306	10	i	i	PRON
fnp-3801	306	11	interferonopathies	interferonopathie	NOUN
fnp-3801	306	12	.	.	PUNCT
fnp-3801	307	1	annu	annu	PROPN
fnp-3801	307	2	rev	rev	VERB
fnp-3801	307	3	med	med	PROPN
fnp-3801	307	4	,	,	PUNCT
fnp-3801	307	5	2017	2017	NUM
fnp-3801	307	6	.	.	PUNCT
fnp-3801	308	1	68	68	NUM
fnp-3801	308	2	:	:	PUNCT
fnp-3801	309	1	p.	p.	NOUN
fnp-3801	309	2	297	297	NUM
fnp-3801	309	3	-	-	SYM
fnp-3801	309	4	315	315	NUM
fnp-3801	309	5	.	.	PUNCT
fnp-3801	310	1	campbell	campbell	PROPN
fnp-3801	310	2	,	,	PUNCT
fnp-3801	310	3	i.l	i.l	PROPN
fnp-3801	310	4	.	.	PROPN
fnp-3801	310	5	,	,	PUNCT
fnp-3801	310	6	et	et	PROPN
fnp-3801	310	7	al	al	PROPN
fnp-3801	310	8	.	.	PROPN
fnp-3801	310	9	,	,	PUNCT
fnp-3801	310	10	structural	structural	ADJ
fnp-3801	310	11	and	and	CCONJ
fnp-3801	310	12	functional	functional	ADJ
fnp-3801	310	13	neuropathology	neuropathology	NOUN
fnp-3801	310	14	in	in	ADP
fnp-3801	310	15	transgenic	transgenic	NOUN
fnp-3801	310	16	mice	mouse	NOUN
fnp-3801	310	17	with	with	ADP
fnp-3801	310	18	cns	cns	NOUN
fnp-3801	310	19	expression	expression	NOUN
fnp-3801	310	20	of	of	ADP
fnp-3801	310	21	ifn	ifn	PROPN
fnp-3801	310	22	-	-	PUNCT
fnp-3801	310	23	alpha	alpha	NOUN
fnp-3801	310	24	.	.	PUNCT
fnp-3801	311	1	brain	brain	NOUN
fnp-3801	311	2	res	re	NOUN
fnp-3801	311	3	,	,	PUNCT
fnp-3801	311	4	1999	1999	NUM
fnp-3801	311	5	.	.	PUNCT
fnp-3801	312	1	835(1	835(1	NUM
fnp-3801	312	2	):	):	PUNCT
fnp-3801	312	3	p.	p.	NOUN
fnp-3801	312	4	46	46	NUM
fnp-3801	312	5	-	-	SYM
fnp-3801	312	6	61	61	NUM
fnp-3801	312	7	.	.	PUNCT
fnp-3801	313	1	pokatayev	pokatayev	PROPN
fnp-3801	313	2	,	,	PUNCT
fnp-3801	313	3	v.	v.	ADV
fnp-3801	313	4	,	,	PUNCT
fnp-3801	313	5	et	et	PROPN
fnp-3801	313	6	al	al	PROPN
fnp-3801	313	7	.	.	PROPN
fnp-3801	313	8	,	,	PUNCT
fnp-3801	313	9	rnase	rnase	PROPN
fnp-3801	313	10	h2	h2	PROPN
fnp-3801	313	11	catalytic	catalytic	ADJ
fnp-3801	313	12	core	core	NOUN
fnp-3801	313	13	aicardi	aicardi	NOUN
fnp-3801	313	14	-	-	PUNCT
fnp-3801	313	15	goutieres	goutiere	NOUN
fnp-3801	313	16	syndrome	syndrome	NOUN
fnp-3801	313	17	-	-	PUNCT
fnp-3801	313	18	related	relate	VERB
fnp-3801	313	19	mutant	mutant	NOUN
fnp-3801	313	20	invokes	invoke	VERB
fnp-3801	313	21	cgas	cgas	ADV
fnp-3801	313	22	-	-	PUNCT
fnp-3801	313	23	sting	sting	ADJ
fnp-3801	313	24	innate	innate	ADJ
fnp-3801	313	25	immune	immune	NOUN
fnp-3801	313	26	-	-	PUNCT
fnp-3801	313	27	sensing	sense	VERB
fnp-3801	313	28	pathway	pathway	NOUN
fnp-3801	313	29	in	in	ADP
fnp-3801	313	30	mice	mouse	NOUN
fnp-3801	313	31	.	.	PUNCT
fnp-3801	314	1	j	j	PROPN
fnp-3801	314	2	exp	exp	NOUN
fnp-3801	314	3	med	med	PROPN
fnp-3801	314	4	,	,	PUNCT
fnp-3801	314	5	2016	2016	NUM
fnp-3801	314	6	.	.	PUNCT
fnp-3801	315	1	213(3	213(3	NUM
fnp-3801	315	2	):	):	PUNCT
fnp-3801	316	1	p.	p.	NOUN
fnp-3801	316	2	329	329	NUM
fnp-3801	316	3	-	-	SYM
fnp-3801	316	4	36	36	NUM
fnp-3801	316	5	.	.	PUNCT
fnp-3801	317	1	mackenzie	mackenzie	PROPN
fnp-3801	317	2	,	,	PUNCT
fnp-3801	317	3	k.j	k.j	PROPN
fnp-3801	317	4	.	.	PROPN
fnp-3801	317	5	,	,	PUNCT
fnp-3801	317	6	et	et	PROPN
fnp-3801	317	7	al	al	PROPN
fnp-3801	317	8	.	.	PROPN
fnp-3801	317	9	,	,	PUNCT
fnp-3801	317	10	ribonuclease	ribonuclease	NOUN
fnp-3801	317	11	h2	h2	NOUN
fnp-3801	317	12	mutations	mutation	NOUN
fnp-3801	317	13	induce	induce	VERB
fnp-3801	317	14	a	a	DET
fnp-3801	317	15	cgas	cgas	ADV
fnp-3801	317	16	/	/	SYM
fnp-3801	317	17	sting	sting	ADJ
fnp-3801	317	18	-	-	PUNCT
fnp-3801	317	19	dependent	dependent	ADJ
fnp-3801	317	20	innate	innate	ADJ
fnp-3801	317	21	immune	immune	ADJ
fnp-3801	317	22	response	response	NOUN
fnp-3801	317	23	.	.	PUNCT
fnp-3801	318	1	embo	embo	PROPN
fnp-3801	318	2	j	j	PROPN
fnp-3801	318	3	,	,	PUNCT
fnp-3801	318	4	2016	2016	NUM
fnp-3801	318	5	.	.	PUNCT
fnp-3801	319	1	35(8	35(8	NUM
fnp-3801	319	2	):	):	PUNCT
fnp-3801	320	1	p.	p.	NOUN
fnp-3801	320	2	831	831	NUM
fnp-3801	320	3	-	-	SYM
fnp-3801	320	4	44	44	NUM
fnp-3801	320	5	.	.	PUNCT
fnp-3801	321	1	aditi	aditi	PROPN
fnp-3801	321	2	,	,	PUNCT
fnp-3801	321	3	s.m.d	s.m.d	PROPN
fnp-3801	321	4	.	.	PUNCT
fnp-3801	321	5	,	,	PUNCT
fnp-3801	321	6	et	et	PROPN
fnp-3801	321	7	al	al	PROPN
fnp-3801	321	8	.	.	PROPN
fnp-3801	321	9	,	,	PUNCT
fnp-3801	321	10	genome	genome	NOUN
fnp-3801	321	11	instability	instability	NOUN
fnp-3801	321	12	independent	independent	ADJ
fnp-3801	321	13	of	of	ADP
fnp-3801	321	14	type	type	NOUN
fnp-3801	321	15	i	i	PRON
fnp-3801	321	16	interferon	interferon	ADJ
fnp-3801	321	17	signaling	signal	VERB
fnp-3801	321	18	drives	drive	NOUN
fnp-3801	321	19	neuropathology	neuropathology	NOUN
fnp-3801	321	20	caused	cause	VERB
fnp-3801	321	21	by	by	ADP
fnp-3801	321	22	impaired	impaired	ADJ
fnp-3801	321	23	ribonucleotide	ribonucleotide	NOUN
fnp-3801	321	24	excision	excision	NOUN
fnp-3801	321	25	repair	repair	NOUN
fnp-3801	321	26	.	.	PUNCT
fnp-3801	322	1	neuron	neuron	PROPN
fnp-3801	322	2	,	,	PUNCT
fnp-3801	322	3	2021	2021	NUM
fnp-3801	322	4	.	.	PUNCT
fnp-3801	323	1	109(24	109(24	NUM
fnp-3801	323	2	):	):	PUNCT
fnp-3801	323	3	p.	p.	NOUN
fnp-3801	323	4	3962	3962	NUM
fnp-3801	323	5	-	-	SYM
fnp-3801	323	6	3979	3979	NUM
fnp-3801	323	7	e6	e6	NOUN
fnp-3801	323	8	.	.	PUNCT
fnp-3801	324	1	porter	porter	PROPN
fnp-3801	324	2	,	,	PUNCT
fnp-3801	324	3	r.s	r.s	PROPN
fnp-3801	324	4	.	.	PROPN
fnp-3801	324	5	,	,	PUNCT
fnp-3801	324	6	et	et	PROPN
fnp-3801	324	7	al	al	PROPN
fnp-3801	324	8	.	.	PROPN
fnp-3801	324	9	,	,	PUNCT
fnp-3801	324	10	neuron	neuron	NOUN
fnp-3801	324	11	-	-	PUNCT
fnp-3801	324	12	specific	specific	ADJ
fnp-3801	324	13	alternative	alternative	ADJ
fnp-3801	324	14	splicing	splicing	NOUN
fnp-3801	324	15	of	of	ADP
fnp-3801	324	16	transcriptional	transcriptional	ADJ
fnp-3801	324	17	machineries	machinery	NOUN
fnp-3801	324	18	:	:	PUNCT
fnp-3801	324	19	implications	implication	NOUN
fnp-3801	324	20	for	for	ADP
fnp-3801	324	21	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	324	22	disorders	disorder	NOUN
fnp-3801	324	23	.	.	PUNCT
fnp-3801	325	1	mol	mol	ADP
fnp-3801	325	2	cell	cell	NOUN
fnp-3801	325	3	neurosci	neurosci	NOUN
fnp-3801	325	4	,	,	PUNCT
fnp-3801	325	5	2018	2018	NUM
fnp-3801	325	6	.	.	PUNCT
fnp-3801	326	1	87	87	NUM
fnp-3801	326	2	:	:	PUNCT
fnp-3801	326	3	p.	p.	NOUN
fnp-3801	326	4	35	35	NUM
fnp-3801	326	5	-	-	SYM
fnp-3801	326	6	45	45	NUM
fnp-3801	326	7	.	.	PUNCT
fnp-3801	326	8	su	su	PROPN
fnp-3801	326	9	,	,	PUNCT
fnp-3801	326	10	c.h	c.h	PROPN
fnp-3801	326	11	.	.	PROPN
fnp-3801	326	12	,	,	PUNCT
fnp-3801	326	13	et	et	PROPN
fnp-3801	326	14	al	al	PROPN
fnp-3801	326	15	.	.	PROPN
fnp-3801	326	16	,	,	PUNCT
fnp-3801	326	17	alternative	alternative	ADJ
fnp-3801	326	18	splicing	splicing	NOUN
fnp-3801	326	19	in	in	ADP
fnp-3801	326	20	neurogenesis	neurogenesis	NOUN
fnp-3801	326	21	and	and	CCONJ
fnp-3801	326	22	brain	brain	NOUN
fnp-3801	326	23	development	development	NOUN
fnp-3801	326	24	.	.	PUNCT
fnp-3801	327	1	front	front	NOUN
fnp-3801	327	2	mol	mol	ADP
fnp-3801	327	3	biosci	biosci	PROPN
fnp-3801	327	4	,	,	PUNCT
fnp-3801	327	5	2018	2018	NUM
fnp-3801	327	6	.	.	PUNCT
fnp-3801	328	1	5	5	NUM
fnp-3801	328	2	:	:	PUNCT
fnp-3801	328	3	p.	p.	NOUN
fnp-3801	328	4	12	12	NUM
fnp-3801	328	5	.	.	PUNCT
fnp-3801	329	1	weyn	weyn	VERB
fnp-3801	329	2	-	-	PUNCT
fnp-3801	329	3	vanhentenryck	vanhentenryck	NOUN
fnp-3801	329	4	,	,	PUNCT
fnp-3801	329	5	s.m	s.m	PROPN
fnp-3801	329	6	.	.	PROPN
fnp-3801	329	7	,	,	PUNCT
fnp-3801	329	8	et	et	PROPN
fnp-3801	329	9	al	al	PROPN
fnp-3801	329	10	.	.	PROPN
fnp-3801	329	11	,	,	PUNCT
fnp-3801	329	12	precise	precise	ADJ
fnp-3801	329	13	temporal	temporal	ADJ
fnp-3801	329	14	regulation	regulation	NOUN
fnp-3801	329	15	of	of	ADP
fnp-3801	329	16	alternative	alternative	ADJ
fnp-3801	329	17	splicing	splicing	NOUN
fnp-3801	329	18	during	during	ADP
fnp-3801	329	19	neural	neural	ADJ
fnp-3801	329	20	development	development	NOUN
fnp-3801	329	21	.	.	PUNCT
fnp-3801	330	1	nat	nat	PROPN
fnp-3801	330	2	commun	commun	PROPN
fnp-3801	330	3	,	,	PUNCT
fnp-3801	330	4	2018	2018	NUM
fnp-3801	330	5	.	.	PUNCT
fnp-3801	331	1	9(1	9(1	NUM
fnp-3801	331	2	):	):	PUNCT
fnp-3801	331	3	p.	p.	NOUN
fnp-3801	331	4	2189	2189	NUM
fnp-3801	331	5	.	.	PUNCT
fnp-3801	332	1	meldolesi	meldolesi	PROPN
fnp-3801	332	2	,	,	PUNCT
fnp-3801	332	3	j.	j.	PROPN
fnp-3801	332	4	,	,	PUNCT
fnp-3801	332	5	alternative	alternative	ADJ
fnp-3801	332	6	splicing	splicing	NOUN
fnp-3801	332	7	by	by	ADP
fnp-3801	332	8	nova	nova	PROPN
fnp-3801	332	9	factors	factor	NOUN
fnp-3801	332	10	:	:	PUNCT
fnp-3801	332	11	from	from	ADP
fnp-3801	332	12	gene	gene	NOUN
fnp-3801	332	13	expression	expression	NOUN
fnp-3801	332	14	to	to	PART
fnp-3801	332	15	cell	cell	NOUN
fnp-3801	332	16	physiology	physiology	NOUN
fnp-3801	332	17	and	and	CCONJ
fnp-3801	332	18	pathology	pathology	NOUN
fnp-3801	332	19	.	.	PUNCT
fnp-3801	333	1	int	int	PROPN
fnp-3801	333	2	j	j	PROPN
fnp-3801	333	3	mol	mol	ADP
fnp-3801	333	4	sci	sci	PROPN
fnp-3801	333	5	,	,	PUNCT
fnp-3801	333	6	2020	2020	NUM
fnp-3801	333	7	.	.	PUNCT
fnp-3801	334	1	21(11	21(11	NUM
fnp-3801	334	2	):	):	PUNCT
fnp-3801	334	3	p.	p.	NOUN
fnp-3801	334	4	3941	3941	NUM
fnp-3801	334	5	.	.	PUNCT
fnp-3801	335	1	xin	xin	PROPN
fnp-3801	335	2	,	,	PUNCT
fnp-3801	335	3	y.	y.	PROPN
fnp-3801	335	4	,	,	PUNCT
fnp-3801	335	5	et	et	PROPN
fnp-3801	335	6	al	al	PROPN
fnp-3801	335	7	.	.	PROPN
fnp-3801	335	8	,	,	PUNCT
fnp-3801	335	9	neuro	neuro	NOUN
fnp-3801	335	10	-	-	PUNCT
fnp-3801	335	11	oncological	oncological	ADJ
fnp-3801	335	12	ventral	ventral	ADJ
fnp-3801	335	13	antigen	antigen	NOUN
fnp-3801	335	14	1	1	NUM
fnp-3801	335	15	(	(	PUNCT
fnp-3801	335	16	nova1	nova1	X
fnp-3801	335	17	):	):	PUNCT
fnp-3801	335	18	implications	implication	NOUN
fnp-3801	335	19	in	in	ADP
fnp-3801	335	20	neurological	neurological	ADJ
fnp-3801	335	21	diseases	disease	NOUN
fnp-3801	335	22	and	and	CCONJ
fnp-3801	335	23	cancers	cancer	NOUN
fnp-3801	335	24	.	.	PUNCT
fnp-3801	336	1	cell	cell	NOUN
fnp-3801	336	2	prolif	prolif	NOUN
fnp-3801	336	3	,	,	PUNCT
fnp-3801	336	4	2017	2017	NUM
fnp-3801	336	5	.	.	PUNCT
fnp-3801	337	1	50(4	50(4	NUM
fnp-3801	337	2	):	):	PUNCT
fnp-3801	337	3	p.	p.	NOUN
fnp-3801	337	4	e12348	e12348	PROPN
fnp-3801	337	5	.	.	PUNCT
fnp-3801	338	1	parikshak	parikshak	PROPN
fnp-3801	338	2	,	,	PUNCT
fnp-3801	338	3	n.n	n.n	PROPN
fnp-3801	338	4	.	.	PROPN
fnp-3801	338	5	,	,	PUNCT
fnp-3801	338	6	et	et	PROPN
fnp-3801	338	7	al	al	PROPN
fnp-3801	338	8	.	.	PROPN
fnp-3801	338	9	,	,	PUNCT
fnp-3801	338	10	genome	genome	NOUN
fnp-3801	338	11	-	-	PUNCT
fnp-3801	338	12	wide	wide	ADJ
fnp-3801	338	13	changes	change	NOUN
fnp-3801	338	14	in	in	ADP
fnp-3801	338	15	lncrna	lncrna	NOUN
fnp-3801	338	16	,	,	PUNCT
fnp-3801	338	17	splicing	splicing	NOUN
fnp-3801	338	18	,	,	PUNCT
fnp-3801	338	19	and	and	CCONJ
fnp-3801	338	20	regional	regional	ADJ
fnp-3801	338	21	gene	gene	NOUN
fnp-3801	338	22	expression	expression	NOUN
fnp-3801	338	23	patterns	pattern	NOUN
fnp-3801	338	24	in	in	ADP
fnp-3801	338	25	autism	autism	NOUN
fnp-3801	338	26	.	.	PUNCT
fnp-3801	339	1	nature	nature	NOUN
fnp-3801	339	2	,	,	PUNCT
fnp-3801	339	3	2016	2016	NUM
fnp-3801	339	4	.	.	PUNCT
fnp-3801	340	1	540(7633	540(7633	NUM
fnp-3801	340	2	):	):	PUNCT
fnp-3801	341	1	p.	p.	NOUN
fnp-3801	341	2	423	423	NUM
fnp-3801	341	3	-	-	SYM
fnp-3801	341	4	7	7	NUM
fnp-3801	341	5	.	.	PUNCT
fnp-3801	342	1	jensen	jensen	PROPN
fnp-3801	342	2	,	,	PUNCT
fnp-3801	342	3	k.b	k.b	PROPN
fnp-3801	342	4	.	.	PROPN
fnp-3801	342	5	,	,	PUNCT
fnp-3801	342	6	et	et	PROPN
fnp-3801	342	7	al	al	PROPN
fnp-3801	342	8	.	.	PROPN
fnp-3801	342	9	,	,	PUNCT
fnp-3801	342	10	nova-1	nova-1	NUM
fnp-3801	342	11	regulates	regulate	VERB
fnp-3801	342	12	neuron	neuron	NOUN
fnp-3801	342	13	-	-	PUNCT
fnp-3801	342	14	specific	specific	ADJ
fnp-3801	342	15	alternative	alternative	ADJ
fnp-3801	342	16	splicing	splicing	NOUN
fnp-3801	342	17	and	and	CCONJ
fnp-3801	342	18	is	be	AUX
fnp-3801	342	19	essential	essential	ADJ
fnp-3801	342	20	for	for	ADP
fnp-3801	342	21	neuronal	neuronal	ADJ
fnp-3801	342	22	viability	viability	NOUN
fnp-3801	342	23	.	.	PUNCT
fnp-3801	343	1	neuron	neuron	PROPN
fnp-3801	343	2	,	,	PUNCT
fnp-3801	343	3	2000	2000	NUM
fnp-3801	343	4	.	.	PUNCT
fnp-3801	344	1	25(2	25(2	NUM
fnp-3801	344	2	):	):	PUNCT
fnp-3801	344	3	p.	p.	NOUN
fnp-3801	344	4	359	359	NUM
fnp-3801	344	5	-	-	SYM
fnp-3801	344	6	71	71	NUM
fnp-3801	344	7	.	.	PUNCT
fnp-3801	345	1	ruggiu	ruggiu	NOUN
fnp-3801	345	2	,	,	PUNCT
fnp-3801	345	3	m.	m.	NOUN
fnp-3801	345	4	,	,	PUNCT
fnp-3801	345	5	et	et	PROPN
fnp-3801	345	6	al	al	PROPN
fnp-3801	345	7	.	.	PROPN
fnp-3801	345	8	,	,	PUNCT
fnp-3801	345	9	rescuing	rescue	VERB
fnp-3801	345	10	z+	z+	NUM
fnp-3801	345	11	agrin	agrin	NOUN
fnp-3801	345	12	splicing	splicing	NOUN
fnp-3801	345	13	in	in	ADP
fnp-3801	345	14	nova	nova	PROPN
fnp-3801	345	15	null	null	ADJ
fnp-3801	345	16	mice	mouse	NOUN
fnp-3801	345	17	restores	restore	VERB
fnp-3801	345	18	synapse	synapse	NOUN
fnp-3801	345	19	formation	formation	NOUN
fnp-3801	345	20	and	and	CCONJ
fnp-3801	345	21	unmasks	unmask	VERB
fnp-3801	345	22	a	a	DET
fnp-3801	345	23	physiologic	physiologic	ADJ
fnp-3801	345	24	defect	defect	NOUN
fnp-3801	345	25	in	in	ADP
fnp-3801	345	26	motor	motor	NOUN
fnp-3801	345	27	neuron	neuron	NOUN
fnp-3801	345	28	firing	fire	VERB
fnp-3801	345	29	.	.	PUNCT
fnp-3801	346	1	proc	proc	PROPN
fnp-3801	346	2	natl	natl	PROPN
fnp-3801	346	3	acad	acad	PROPN
fnp-3801	346	4	sci	sci	PROPN
fnp-3801	346	5	u	u	PROPN
fnp-3801	346	6	s	s	PROPN
fnp-3801	346	7	a	a	PRON
fnp-3801	346	8	,	,	PUNCT
fnp-3801	346	9	2009	2009	NUM
fnp-3801	346	10	.	.	PUNCT
fnp-3801	347	1	106(9	106(9	NUM
fnp-3801	347	2	):	):	PUNCT
fnp-3801	347	3	p.	p.	NOUN
fnp-3801	347	4	3513	3513	NUM
fnp-3801	347	5	-	-	SYM
fnp-3801	347	6	8	8	NUM
fnp-3801	347	7	.	.	X
fnp-3801	347	8	trujillo	trujillo	PROPN
fnp-3801	347	9	,	,	PUNCT
fnp-3801	347	10	c.a	c.a	PROPN
fnp-3801	347	11	.	.	PROPN
fnp-3801	347	12	,	,	PUNCT
fnp-3801	347	13	et	et	PROPN
fnp-3801	347	14	al	al	PROPN
fnp-3801	347	15	.	.	PROPN
fnp-3801	347	16	,	,	PUNCT
fnp-3801	347	17	reintroduction	reintroduction	NOUN
fnp-3801	347	18	of	of	ADP
fnp-3801	347	19	the	the	DET
fnp-3801	347	20	archaic	archaic	ADJ
fnp-3801	347	21	variant	variant	NOUN
fnp-3801	347	22	of	of	ADP
fnp-3801	347	23	nova1	nova1	NOUN
fnp-3801	347	24	in	in	ADP
fnp-3801	347	25	cortical	cortical	ADJ
fnp-3801	347	26	organoids	organoid	NOUN
fnp-3801	347	27	alters	alter	VERB
fnp-3801	347	28	neurodevelopment	neurodevelopment	ADJ
fnp-3801	347	29	.	.	PUNCT
fnp-3801	348	1	science	science	NOUN
fnp-3801	348	2	,	,	PUNCT
fnp-3801	348	3	2021	2021	NUM
fnp-3801	348	4	.	.	PUNCT
fnp-3801	349	1	371(6530	371(6530	NUM
fnp-3801	349	2	)	)	PUNCT
fnp-3801	349	3	.	.	PUNCT
fnp-3801	350	1	samarasinghe	samarasinghe	PROPN
fnp-3801	350	2	,	,	PUNCT
fnp-3801	350	3	r.a	r.a	PROPN
fnp-3801	350	4	.	.	PROPN
fnp-3801	350	5	,	,	PUNCT
fnp-3801	350	6	et	et	PROPN
fnp-3801	350	7	al	al	PROPN
fnp-3801	350	8	.	.	PROPN
fnp-3801	350	9	,	,	PUNCT
fnp-3801	350	10	identification	identification	NOUN
fnp-3801	350	11	of	of	ADP
fnp-3801	350	12	neural	neural	ADJ
fnp-3801	350	13	oscillations	oscillation	NOUN
fnp-3801	350	14	and	and	CCONJ
fnp-3801	350	15	epileptiform	epileptiform	NOUN
fnp-3801	350	16	changes	change	NOUN
fnp-3801	350	17	in	in	ADP
fnp-3801	350	18	human	human	ADJ
fnp-3801	350	19	brain	brain	NOUN
fnp-3801	350	20	organoids	organoid	NOUN
fnp-3801	350	21	.	.	PUNCT
fnp-3801	351	1	nat	nat	PROPN
fnp-3801	351	2	neurosci	neurosci	PROPN
fnp-3801	351	3	,	,	PUNCT
fnp-3801	351	4	2021	2021	NUM
fnp-3801	351	5	.	.	PUNCT
fnp-3801	352	1	24(10	24(10	NUM
fnp-3801	352	2	):	):	PUNCT
fnp-3801	352	3	p.	p.	NOUN
fnp-3801	352	4	1488	1488	NUM
fnp-3801	352	5	-	-	SYM
fnp-3801	352	6	1500	1500	NUM
fnp-3801	352	7	.	.	PUNCT
fnp-3801	353	1	trujillo	trujillo	PROPN
fnp-3801	353	2	,	,	PUNCT
fnp-3801	353	3	c.a	c.a	PROPN
fnp-3801	353	4	.	.	PROPN
fnp-3801	353	5	,	,	PUNCT
fnp-3801	353	6	et	et	PROPN
fnp-3801	353	7	al	al	PROPN
fnp-3801	353	8	.	.	PROPN
fnp-3801	353	9	,	,	PUNCT
fnp-3801	353	10	pharmacological	pharmacological	ADJ
fnp-3801	353	11	reversal	reversal	NOUN
fnp-3801	353	12	of	of	ADP
fnp-3801	353	13	synaptic	synaptic	ADJ
fnp-3801	353	14	and	and	CCONJ
fnp-3801	353	15	network	network	NOUN
fnp-3801	353	16	pathology	pathology	NOUN
fnp-3801	353	17	in	in	ADP
fnp-3801	353	18	human	human	ADJ
fnp-3801	353	19	mecp2	mecp2	NOUN
fnp-3801	353	20	-	-	PUNCT
fnp-3801	353	21	ko	ko	NOUN
fnp-3801	353	22	neurons	neuron	NOUN
fnp-3801	353	23	and	and	CCONJ
fnp-3801	353	24	cortical	cortical	ADJ
fnp-3801	353	25	organoids	organoid	NOUN
fnp-3801	353	26	.	.	PUNCT
fnp-3801	354	1	embo	embo	NOUN
fnp-3801	354	2	mol	mol	ADP
fnp-3801	354	3	med	med	PROPN
fnp-3801	354	4	,	,	PUNCT
fnp-3801	354	5	2021	2021	NUM
fnp-3801	354	6	.	.	PUNCT
fnp-3801	355	1	13(1	13(1	NUM
fnp-3801	355	2	):	):	PUNCT
fnp-3801	356	1	p.	p.	PROPN
fnp-3801	356	2	e12523	e12523	PROPN
fnp-3801	356	3	.	.	PUNCT
fnp-3801	357	1	philibert	philibert	PROPN
fnp-3801	357	2	,	,	PUNCT
fnp-3801	357	3	r.a	r.a	PROPN
fnp-3801	357	4	.	.	PROPN
fnp-3801	357	5	and	and	CCONJ
fnp-3801	357	6	a.	a.	PROPN
fnp-3801	357	7	madan	madan	PROPN
fnp-3801	357	8	,	,	PUNCT
fnp-3801	357	9	role	role	NOUN
fnp-3801	357	10	of	of	ADP
fnp-3801	357	11	med12	med12	PROPN
fnp-3801	357	12	in	in	ADP
fnp-3801	357	13	transcription	transcription	NOUN
fnp-3801	357	14	and	and	CCONJ
fnp-3801	357	15	human	human	ADJ
fnp-3801	357	16	behavior	behavior	NOUN
fnp-3801	357	17	.	.	PUNCT
fnp-3801	358	1	pharmacogenomics	pharmacogenomic	NOUN
fnp-3801	358	2	,	,	PUNCT
fnp-3801	358	3	2007	2007	NUM
fnp-3801	358	4	.	.	PUNCT
fnp-3801	359	1	8(8	8(8	NUM
fnp-3801	359	2	):	):	PUNCT
fnp-3801	360	1	p.	p.	NOUN
fnp-3801	360	2	909	909	NUM
fnp-3801	360	3	-	-	SYM
fnp-3801	360	4	16	16	NUM
fnp-3801	360	5	.	.	PUNCT
fnp-3801	361	1	remeseiro	remeseiro	PROPN
fnp-3801	361	2	,	,	PUNCT
fnp-3801	361	3	s.	s.	PROPN
fnp-3801	361	4	,	,	PUNCT
fnp-3801	361	5	et	et	PROPN
fnp-3801	361	6	al	al	PROPN
fnp-3801	361	7	.	.	PROPN
fnp-3801	361	8	,	,	PUNCT
fnp-3801	361	9	reduction	reduction	NOUN
fnp-3801	361	10	of	of	ADP
fnp-3801	361	11	nipbl	nipbl	PROPN
fnp-3801	361	12	impairs	impair	VERB
fnp-3801	361	13	cohesin	cohesin	NOUN
fnp-3801	361	14	loading	loading	NOUN
fnp-3801	361	15	locally	locally	ADV
fnp-3801	361	16	and	and	CCONJ
fnp-3801	361	17	affects	affect	VERB
fnp-3801	361	18	transcription	transcription	NOUN
fnp-3801	361	19	but	but	CCONJ
fnp-3801	361	20	not	not	PART
fnp-3801	361	21	cohesion	cohesion	NOUN
fnp-3801	361	22	-	-	PUNCT
fnp-3801	361	23	dependent	dependent	ADJ
fnp-3801	361	24	functions	function	NOUN
fnp-3801	361	25	in	in	ADP
fnp-3801	361	26	a	a	DET
fnp-3801	361	27	mouse	mouse	NOUN
fnp-3801	361	28	model	model	NOUN
fnp-3801	361	29	of	of	ADP
fnp-3801	361	30	cornelia	cornelia	PROPN
fnp-3801	361	31	de	de	PROPN
fnp-3801	361	32	lange	lange	PROPN
fnp-3801	361	33	syndrome	syndrome	NOUN
fnp-3801	361	34	.	.	PUNCT
fnp-3801	362	1	biochim	biochim	PROPN
fnp-3801	362	2	biophys	biophy	NOUN
fnp-3801	362	3	acta	acta	PROPN
fnp-3801	362	4	,	,	PUNCT
fnp-3801	362	5	2013	2013	NUM
fnp-3801	362	6	.	.	PUNCT
fnp-3801	363	1	1832(12	1832(12	NUM
fnp-3801	363	2	):	):	PUNCT
fnp-3801	363	3	p.	p.	NOUN
fnp-3801	363	4	2097	2097	NUM
fnp-3801	363	5	-	-	SYM
fnp-3801	363	6	102	102	NUM
fnp-3801	363	7	.	.	PUNCT
fnp-3801	364	1	gregor	gregor	PROPN
fnp-3801	364	2	,	,	PUNCT
fnp-3801	364	3	a.	a.	PROPN
fnp-3801	364	4	,	,	PUNCT
fnp-3801	364	5	et	et	PROPN
fnp-3801	364	6	al	al	PROPN
fnp-3801	364	7	.	.	PROPN
fnp-3801	364	8	,	,	PUNCT
fnp-3801	364	9	de	de	PROPN
fnp-3801	364	10	novo	novo	NOUN
fnp-3801	364	11	mutations	mutation	NOUN
fnp-3801	364	12	in	in	ADP
fnp-3801	364	13	the	the	DET
fnp-3801	364	14	genome	genome	NOUN
fnp-3801	364	15	organizer	organizer	NOUN
fnp-3801	364	16	ctcf	ctcf	NOUN
fnp-3801	364	17	cause	cause	VERB
fnp-3801	364	18	intellectual	intellectual	ADJ
fnp-3801	364	19	disability	disability	NOUN
fnp-3801	364	20	.	.	PUNCT
fnp-3801	365	1	am	be	AUX
fnp-3801	365	2	j	j	PROPN
fnp-3801	365	3	hum	hum	PROPN
fnp-3801	365	4	genet	genet	PROPN
fnp-3801	365	5	,	,	PUNCT
fnp-3801	365	6	2013	2013	NUM
fnp-3801	365	7	.	.	PUNCT
fnp-3801	366	1	93(1	93(1	NUM
fnp-3801	366	2	):	):	PUNCT
fnp-3801	367	1	p.	p.	NOUN
fnp-3801	367	2	124	124	NUM
fnp-3801	367	3	-	-	SYM
fnp-3801	367	4	31	31	NUM
fnp-3801	367	5	.	.	PUNCT
fnp-3801	368	1	jaitner	jaitner	PROPN
fnp-3801	368	2	,	,	PUNCT
fnp-3801	368	3	c.	c.	PROPN
fnp-3801	368	4	,	,	PUNCT
fnp-3801	368	5	et	et	PROPN
fnp-3801	368	6	al	al	PROPN
fnp-3801	368	7	.	.	PROPN
fnp-3801	368	8	,	,	PUNCT
fnp-3801	368	9	satb2	satb2	NOUN
fnp-3801	368	10	determines	determine	VERB
fnp-3801	368	11	mirna	mirna	NOUN
fnp-3801	368	12	expression	expression	NOUN
fnp-3801	368	13	and	and	CCONJ
fnp-3801	368	14	long	long	ADJ
fnp-3801	368	15	-	-	PUNCT
fnp-3801	368	16	term	term	NOUN
fnp-3801	368	17	memory	memory	NOUN
fnp-3801	368	18	in	in	ADP
fnp-3801	368	19	the	the	DET
fnp-3801	368	20	adult	adult	NOUN
fnp-3801	368	21	central	central	ADJ
fnp-3801	368	22	nervous	nervous	ADJ
fnp-3801	368	23	system	system	NOUN
fnp-3801	368	24	.	.	PUNCT
fnp-3801	369	1	elife	elife	NOUN
fnp-3801	369	2	,	,	PUNCT
fnp-3801	369	3	2016	2016	NUM
fnp-3801	369	4	.	.	PUNCT
fnp-3801	370	1	5	5	NUM
fnp-3801	370	2	:	:	PUNCT
fnp-3801	370	3	p.	p.	NOUN
fnp-3801	370	4	e17361	e17361	PROPN
fnp-3801	370	5	.	.	PUNCT
fnp-3801	371	1	tan	tan	PROPN
fnp-3801	371	2	,	,	PUNCT
fnp-3801	371	3	l.	l.	PROPN
fnp-3801	371	4	,	,	PUNCT
fnp-3801	371	5	et	et	PROPN
fnp-3801	371	6	al	al	PROPN
fnp-3801	371	7	.	.	PROPN
fnp-3801	371	8	,	,	PUNCT
fnp-3801	371	9	changes	change	NOUN
fnp-3801	371	10	in	in	ADP
fnp-3801	371	11	genome	genome	NOUN
fnp-3801	371	12	architecture	architecture	NOUN
fnp-3801	371	13	and	and	CCONJ
fnp-3801	371	14	transcriptional	transcriptional	ADJ
fnp-3801	371	15	dynamics	dynamic	NOUN
fnp-3801	371	16	progress	progress	VERB
fnp-3801	371	17	independently	independently	ADV
fnp-3801	371	18	of	of	ADP
fnp-3801	371	19	sensory	sensory	ADJ
fnp-3801	371	20	experience	experience	NOUN
fnp-3801	371	21	during	during	ADP
fnp-3801	371	22	post	post	ADJ
fnp-3801	371	23	-	-	ADJ
fnp-3801	371	24	natal	natal	ADJ
fnp-3801	371	25	brain	brain	NOUN
fnp-3801	371	26	development	development	NOUN
fnp-3801	371	27	.	.	PUNCT
fnp-3801	372	1	cell	cell	NOUN
fnp-3801	372	2	,	,	PUNCT
fnp-3801	372	3	2021	2021	NUM
fnp-3801	372	4	.	.	PUNCT
fnp-3801	373	1	184(3	184(3	NUM
fnp-3801	373	2	):	):	PUNCT
fnp-3801	373	3	p.	p.	NOUN
fnp-3801	373	4	741	741	NUM
fnp-3801	373	5	-	-	SYM
fnp-3801	373	6	758	758	NUM
fnp-3801	373	7	e17	e17	NOUN
fnp-3801	373	8	.	.	PUNCT
fnp-3801	374	1	tan	tan	PROPN
fnp-3801	374	2	,	,	PUNCT
fnp-3801	374	3	l.	l.	PROPN
fnp-3801	374	4	,	,	PUNCT
fnp-3801	374	5	et	et	PROPN
fnp-3801	374	6	al	al	PROPN
fnp-3801	374	7	.	.	PROPN
fnp-3801	374	8	,	,	PUNCT
fnp-3801	374	9	three	three	NUM
fnp-3801	374	10	-	-	PUNCT
fnp-3801	374	11	dimensional	dimensional	ADJ
fnp-3801	374	12	genome	genome	NOUN
fnp-3801	374	13	structures	structure	NOUN
fnp-3801	374	14	of	of	ADP
fnp-3801	374	15	single	single	ADJ
fnp-3801	374	16	diploid	diploid	ADJ
fnp-3801	374	17	human	human	ADJ
fnp-3801	374	18	cells	cell	NOUN
fnp-3801	374	19	.	.	PUNCT
fnp-3801	375	1	science	science	NOUN
fnp-3801	375	2	,	,	PUNCT
fnp-3801	375	3	2018	2018	NUM
fnp-3801	375	4	.	.	PUNCT
fnp-3801	376	1	361(6405	361(6405	NUM
fnp-3801	376	2	):	):	PUNCT
fnp-3801	376	3	p.	p.	NOUN
fnp-3801	376	4	924	924	NUM
fnp-3801	376	5	-	-	SYM
fnp-3801	376	6	8	8	NUM
fnp-3801	376	7	.	.	PUNCT
fnp-3801	377	1	winick	winick	PROPN
fnp-3801	377	2	-	-	PUNCT
fnp-3801	377	3	ng	ng	PROPN
fnp-3801	377	4	,	,	PUNCT
fnp-3801	377	5	w.	w.	PROPN
fnp-3801	377	6	,	,	PUNCT
fnp-3801	377	7	et	et	PROPN
fnp-3801	377	8	al	al	PROPN
fnp-3801	377	9	.	.	PROPN
fnp-3801	377	10	,	,	PUNCT
fnp-3801	377	11	cell	cell	NOUN
fnp-3801	377	12	-	-	PUNCT
fnp-3801	377	13	type	type	NOUN
fnp-3801	377	14	specialization	specialization	NOUN
fnp-3801	377	15	is	be	AUX
fnp-3801	377	16	encoded	encode	VERB
fnp-3801	377	17	by	by	ADP
fnp-3801	377	18	specific	specific	ADJ
fnp-3801	377	19	chromatin	chromatin	NOUN
fnp-3801	377	20	topologies	topology	NOUN
fnp-3801	377	21	.	.	PUNCT
fnp-3801	378	1	nature	nature	NOUN
fnp-3801	378	2	,	,	PUNCT
fnp-3801	378	3	2021	2021	NUM
fnp-3801	378	4	.	.	PUNCT
fnp-3801	379	1	599(7886	599(7886	NUM
fnp-3801	379	2	):	):	PUNCT
fnp-3801	379	3	p.	p.	NOUN
fnp-3801	379	4	684	684	NUM
fnp-3801	379	5	-	-	SYM
fnp-3801	379	6	91	91	NUM
fnp-3801	379	7	.	.	PUNCT
fnp-3801	380	1	reichova	reichova	PROPN
fnp-3801	380	2	,	,	PUNCT
fnp-3801	380	3	a.	a.	PROPN
fnp-3801	380	4	,	,	PUNCT
fnp-3801	380	5	et	et	PROPN
fnp-3801	380	6	al	al	PROPN
fnp-3801	380	7	.	.	PROPN
fnp-3801	380	8	,	,	PUNCT
fnp-3801	380	9	abnormalities	abnormality	NOUN
fnp-3801	380	10	in	in	ADP
fnp-3801	380	11	interactions	interaction	NOUN
fnp-3801	380	12	of	of	ADP
fnp-3801	380	13	rho	rho	ADJ
fnp-3801	380	14	gtpases	gtpase	NOUN
fnp-3801	380	15	with	with	ADP
fnp-3801	380	16	scaffolding	scaffold	VERB
fnp-3801	380	17	proteins	protein	NOUN
fnp-3801	380	18	contribute	contribute	VERB
fnp-3801	380	19	to	to	ADP
fnp-3801	380	20	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	380	21	disorders	disorder	NOUN
fnp-3801	380	22	.	.	PUNCT
fnp-3801	381	1	j	j	PROPN
fnp-3801	381	2	neurosci	neurosci	PROPN
fnp-3801	381	3	res	re	NOUN
fnp-3801	381	4	,	,	PUNCT
fnp-3801	381	5	2018	2018	NUM
fnp-3801	381	6	.	.	PUNCT
fnp-3801	382	1	96(5	96(5	NUM
fnp-3801	382	2	):	):	PUNCT
fnp-3801	383	1	p.	p.	NOUN
fnp-3801	383	2	781	781	NUM
fnp-3801	383	3	-	-	SYM
fnp-3801	383	4	8	8	NUM
fnp-3801	383	5	.	.	PUNCT
fnp-3801	384	1	scala	scala	PROPN
fnp-3801	384	2	,	,	PUNCT
fnp-3801	384	3	m.	m.	NOUN
fnp-3801	384	4	,	,	PUNCT
fnp-3801	384	5	et	et	PROPN
fnp-3801	384	6	al	al	PROPN
fnp-3801	384	7	.	.	PROPN
fnp-3801	384	8	,	,	PUNCT
fnp-3801	384	9	pathophysiological	pathophysiological	ADJ
fnp-3801	384	10	mechanisms	mechanism	NOUN
fnp-3801	384	11	in	in	ADP
fnp-3801	384	12	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	384	13	disorders	disorder	NOUN
fnp-3801	384	14	caused	cause	VERB
fnp-3801	384	15	by	by	ADP
fnp-3801	384	16	rac	rac	PROPN
fnp-3801	384	17	gtpases	gtpases	PROPN
fnp-3801	384	18	dysregulation	dysregulation	NOUN
fnp-3801	384	19	:	:	PUNCT
fnp-3801	384	20	what	what	PRON
fnp-3801	384	21	's	be	AUX
fnp-3801	384	22	behind	behind	ADP
fnp-3801	384	23	neuro	neuro	NOUN
fnp-3801	384	24	-	-	PUNCT
fnp-3801	384	25	racopathies	racopathie	NOUN
fnp-3801	384	26	.	.	PUNCT
fnp-3801	385	1	cells	cell	NOUN
fnp-3801	385	2	,	,	PUNCT
fnp-3801	385	3	2021	2021	NUM
fnp-3801	385	4	.	.	PUNCT
fnp-3801	386	1	10(12	10(12	NUM
fnp-3801	386	2	):	):	PUNCT
fnp-3801	386	3	p.	p.	NOUN
fnp-3801	386	4	3395	3395	NUM
fnp-3801	386	5	.	.	PUNCT
fnp-3801	387	1	zeidan	zeidan	PROPN
fnp-3801	387	2	-	-	PUNCT
fnp-3801	387	3	chulia	chulia	PROPN
fnp-3801	387	4	,	,	PUNCT
fnp-3801	387	5	f.	f.	PROPN
fnp-3801	387	6	,	,	PUNCT
fnp-3801	387	7	et	et	PROPN
fnp-3801	387	8	al	al	PROPN
fnp-3801	387	9	.	.	PROPN
fnp-3801	387	10	,	,	PUNCT
fnp-3801	387	11	exploring	explore	VERB
fnp-3801	387	12	the	the	DET
fnp-3801	387	13	multifactorial	multifactorial	ADJ
fnp-3801	387	14	nature	nature	NOUN
fnp-3801	387	15	of	of	ADP
fnp-3801	387	16	autism	autism	NOUN
fnp-3801	387	17	through	through	ADP
fnp-3801	387	18	computational	computational	ADJ
fnp-3801	387	19	systems	system	NOUN
fnp-3801	387	20	biology	biology	NOUN
fnp-3801	387	21	:	:	PUNCT
fnp-3801	387	22	calcium	calcium	NOUN
fnp-3801	387	23	and	and	CCONJ
fnp-3801	387	24	the	the	DET
fnp-3801	387	25	rho	rho	ADJ
fnp-3801	387	26	gtpase	gtpase	NOUN
fnp-3801	387	27	rac1	rac1	NOUN
fnp-3801	387	28	under	under	ADP
fnp-3801	387	29	the	the	DET
fnp-3801	387	30	spotlight	spotlight	NOUN
fnp-3801	387	31	.	.	PUNCT
fnp-3801	388	1	neuromolecular	neuromolecular	PROPN
fnp-3801	388	2	med	med	PROPN
fnp-3801	388	3	,	,	PUNCT
fnp-3801	388	4	2013	2013	NUM
fnp-3801	388	5	.	.	PUNCT
fnp-3801	389	1	15(2	15(2	NUM
fnp-3801	389	2	):	):	PUNCT
fnp-3801	389	3	p.	p.	NOUN
fnp-3801	389	4	364	364	NUM
fnp-3801	389	5	-	-	SYM
fnp-3801	389	6	83	83	NUM
fnp-3801	389	7	.	.	PUNCT
fnp-3801	390	1	guo	guo	PROPN
fnp-3801	390	2	,	,	PUNCT
fnp-3801	390	3	d.	d.	PROPN
fnp-3801	390	4	,	,	PUNCT
fnp-3801	390	5	et	et	PROPN
fnp-3801	390	6	al	al	PROPN
fnp-3801	390	7	.	.	PROPN
fnp-3801	390	8	,	,	PUNCT
fnp-3801	390	9	rho	rho	ADJ
fnp-3801	390	10	gtpase	gtpase	NOUN
fnp-3801	390	11	regulators	regulator	NOUN
fnp-3801	390	12	and	and	CCONJ
fnp-3801	390	13	effectors	effector	NOUN
fnp-3801	390	14	in	in	ADP
fnp-3801	390	15	autism	autism	NOUN
fnp-3801	390	16	spectrum	spectrum	NOUN
fnp-3801	390	17	disorders	disorder	NOUN
fnp-3801	390	18	:	:	PUNCT
fnp-3801	390	19	animal	animal	NOUN
fnp-3801	390	20	models	model	NOUN
fnp-3801	390	21	and	and	CCONJ
fnp-3801	390	22	insights	insight	NOUN
fnp-3801	390	23	for	for	ADP
fnp-3801	390	24	therapeutics	therapeutic	NOUN
fnp-3801	390	25	.	.	PUNCT
fnp-3801	391	1	cells	cell	NOUN
fnp-3801	391	2	,	,	PUNCT
fnp-3801	391	3	2020	2020	NUM
fnp-3801	391	4	.	.	PUNCT
fnp-3801	392	1	9(4	9(4	NUM
fnp-3801	392	2	):	):	PUNCT
fnp-3801	393	1	p.	p.	NOUN
fnp-3801	393	2	835	835	NUM
fnp-3801	393	3	.	.	PUNCT
fnp-3801	394	1	sit	sit	VERB
fnp-3801	394	2	,	,	PUNCT
fnp-3801	394	3	s.t	s.t	PROPN
fnp-3801	394	4	.	.	PROPN
fnp-3801	394	5	and	and	CCONJ
fnp-3801	394	6	e.	e.	PROPN
fnp-3801	394	7	manser	manser	PROPN
fnp-3801	394	8	,	,	PUNCT
fnp-3801	394	9	rho	rho	ADJ
fnp-3801	394	10	gtpases	gtpase	NOUN
fnp-3801	394	11	and	and	CCONJ
fnp-3801	394	12	their	their	PRON
fnp-3801	394	13	role	role	NOUN
fnp-3801	394	14	in	in	ADP
fnp-3801	394	15	organizing	organize	VERB
fnp-3801	394	16	the	the	DET
fnp-3801	394	17	actin	actin	NOUN
fnp-3801	394	18	cytoskeleton	cytoskeleton	PROPN
fnp-3801	394	19	.	.	PUNCT
fnp-3801	395	1	j	j	PROPN
fnp-3801	395	2	cell	cell	PROPN
fnp-3801	395	3	sci	sci	PROPN
fnp-3801	395	4	,	,	PUNCT
fnp-3801	395	5	2011	2011	NUM
fnp-3801	395	6	.	.	PUNCT
fnp-3801	396	1	124(pt	124(pt	NUM
fnp-3801	397	1	5	5	NUM
fnp-3801	397	2	):	):	PUNCT
fnp-3801	397	3	p.	p.	NOUN
fnp-3801	397	4	679	679	NUM
fnp-3801	397	5	-	-	SYM
fnp-3801	397	6	83	83	NUM
fnp-3801	397	7	.	.	PUNCT
fnp-3801	398	1	hall	hall	PROPN
fnp-3801	398	2	,	,	PUNCT
fnp-3801	398	3	a.	a.	NOUN
fnp-3801	398	4	and	and	CCONJ
fnp-3801	398	5	c.d	c.d	PROPN
fnp-3801	398	6	.	.	PROPN
fnp-3801	398	7	nobes	nobes	PROPN
fnp-3801	398	8	,	,	PUNCT
fnp-3801	398	9	rho	rho	ADJ
fnp-3801	398	10	gtpases	gtpase	NOUN
fnp-3801	398	11	:	:	PUNCT
fnp-3801	398	12	molecular	molecular	ADJ
fnp-3801	398	13	switches	switch	NOUN
fnp-3801	398	14	that	that	PRON
fnp-3801	398	15	control	control	VERB
fnp-3801	398	16	the	the	DET
fnp-3801	398	17	organization	organization	NOUN
fnp-3801	398	18	and	and	CCONJ
fnp-3801	398	19	dynamics	dynamic	NOUN
fnp-3801	398	20	of	of	ADP
fnp-3801	398	21	the	the	DET
fnp-3801	398	22	actin	actin	NOUN
fnp-3801	398	23	cytoskeleton	cytoskeleton	PROPN
fnp-3801	398	24	.	.	PUNCT
fnp-3801	399	1	philos	philos	PROPN
fnp-3801	399	2	trans	trans	PROPN
fnp-3801	399	3	r	r	PROPN
fnp-3801	399	4	soc	soc	PROPN
fnp-3801	399	5	lond	lond	PROPN
fnp-3801	399	6	b	b	PROPN
fnp-3801	399	7	biol	biol	PROPN
fnp-3801	399	8	sci	sci	PROPN
fnp-3801	399	9	,	,	PUNCT
fnp-3801	399	10	2000	2000	NUM
fnp-3801	399	11	.	.	PUNCT
fnp-3801	400	1	355(1399	355(1399	NUM
fnp-3801	400	2	):	):	PUNCT
fnp-3801	400	3	p.	p.	NOUN
fnp-3801	400	4	965	965	NUM
fnp-3801	400	5	-	-	SYM
fnp-3801	400	6	70	70	NUM
fnp-3801	400	7	.	.	PUNCT
fnp-3801	401	1	allen	allen	PROPN
fnp-3801	401	2	,	,	PUNCT
fnp-3801	401	3	k.m	k.m	PROPN
fnp-3801	401	4	.	.	PROPN
fnp-3801	401	5	,	,	PUNCT
fnp-3801	401	6	et	et	PROPN
fnp-3801	401	7	al	al	PROPN
fnp-3801	401	8	.	.	PROPN
fnp-3801	401	9	,	,	PUNCT
fnp-3801	401	10	pak3	pak3	NOUN
fnp-3801	401	11	mutation	mutation	NOUN
fnp-3801	401	12	in	in	ADP
fnp-3801	401	13	nonsyndromic	nonsyndromic	ADJ
fnp-3801	401	14	x	x	VERB
fnp-3801	401	15	-	-	VERB
fnp-3801	401	16	linked	link	VERB
fnp-3801	401	17	mental	mental	ADJ
fnp-3801	401	18	retardation	retardation	NOUN
fnp-3801	401	19	.	.	PUNCT
fnp-3801	402	1	nat	nat	PROPN
fnp-3801	402	2	genet	genet	PROPN
fnp-3801	402	3	,	,	PUNCT
fnp-3801	402	4	1998	1998	NUM
fnp-3801	402	5	.	.	PUNCT
fnp-3801	403	1	20(1	20(1	NUM
fnp-3801	403	2	):	):	PUNCT
fnp-3801	403	3	p.	p.	NOUN
fnp-3801	403	4	25	25	NUM
fnp-3801	403	5	-	-	SYM
fnp-3801	403	6	30	30	NUM
fnp-3801	403	7	.	.	PUNCT
fnp-3801	404	1	bienvenu	bienvenu	PROPN
fnp-3801	404	2	,	,	PUNCT
fnp-3801	404	3	t.	t.	PROPN
fnp-3801	404	4	,	,	PUNCT
fnp-3801	404	5	et	et	PROPN
fnp-3801	404	6	al	al	PROPN
fnp-3801	404	7	.	.	PROPN
fnp-3801	404	8	,	,	PUNCT
fnp-3801	404	9	missense	missense	VERB
fnp-3801	404	10	mutation	mutation	NOUN
fnp-3801	404	11	in	in	ADP
fnp-3801	404	12	pak3	pak3	PROPN
fnp-3801	404	13	,	,	PUNCT
fnp-3801	404	14	r67c	r67c	X
fnp-3801	404	15	,	,	PUNCT
fnp-3801	404	16	causes	cause	VERB
fnp-3801	404	17	x	x	ADJ
fnp-3801	404	18	-	-	VERB
fnp-3801	404	19	linked	link	VERB
fnp-3801	404	20	nonspecific	nonspecific	ADJ
fnp-3801	404	21	mental	mental	ADJ
fnp-3801	404	22	retardation	retardation	NOUN
fnp-3801	404	23	.	.	PUNCT
fnp-3801	405	1	am	be	AUX
fnp-3801	405	2	j	j	PROPN
fnp-3801	405	3	med	med	PROPN
fnp-3801	405	4	genet	genet	PROPN
fnp-3801	405	5	,	,	PUNCT
fnp-3801	405	6	2000	2000	NUM
fnp-3801	405	7	.	.	PUNCT
fnp-3801	406	1	93(4	93(4	NOUN
fnp-3801	406	2	):	):	PUNCT
fnp-3801	407	1	p.	p.	NOUN
fnp-3801	407	2	294	294	NUM
fnp-3801	407	3	-	-	SYM
fnp-3801	407	4	8	8	NUM
fnp-3801	407	5	.	.	PUNCT
fnp-3801	408	1	magini	magini	NOUN
fnp-3801	408	2	,	,	PUNCT
fnp-3801	408	3	p.	p.	PROPN
fnp-3801	408	4	,	,	PUNCT
fnp-3801	408	5	et	et	PROPN
fnp-3801	408	6	al	al	PROPN
fnp-3801	408	7	.	.	PROPN
fnp-3801	408	8	,	,	PUNCT
fnp-3801	408	9	a	a	DET
fnp-3801	408	10	mutation	mutation	NOUN
fnp-3801	408	11	in	in	ADP
fnp-3801	408	12	pak3	pak3	NOUN
fnp-3801	408	13	with	with	ADP
fnp-3801	408	14	a	a	DET
fnp-3801	408	15	dual	dual	ADJ
fnp-3801	408	16	molecular	molecular	ADJ
fnp-3801	408	17	effect	effect	NOUN
fnp-3801	408	18	deregulates	deregulate	VERB
fnp-3801	408	19	the	the	DET
fnp-3801	408	20	ras	ras	PROPN
fnp-3801	408	21	/	/	SYM
fnp-3801	408	22	mapk	mapk	NOUN
fnp-3801	408	23	pathway	pathway	NOUN
fnp-3801	408	24	and	and	CCONJ
fnp-3801	408	25	drives	drive	VERB
fnp-3801	408	26	an	an	DET
fnp-3801	408	27	x	x	ADV
fnp-3801	408	28	-	-	ADJ
fnp-3801	408	29	linked	link	VERB
fnp-3801	408	30	syndromic	syndromic	ADJ
fnp-3801	408	31	phenotype	phenotype	NOUN
fnp-3801	408	32	.	.	PUNCT
fnp-3801	409	1	hum	hum	PROPN
fnp-3801	409	2	mol	mol	ADP
fnp-3801	409	3	genet	genet	PROPN
fnp-3801	409	4	,	,	PUNCT
fnp-3801	409	5	2014	2014	NUM
fnp-3801	409	6	.	.	PUNCT
fnp-3801	410	1	23(13	23(13	NUM
fnp-3801	410	2	):	):	PUNCT
fnp-3801	410	3	p.	p.	NOUN
fnp-3801	410	4	3607	3607	NUM
fnp-3801	410	5	-	-	SYM
fnp-3801	410	6	17	17	NUM
fnp-3801	410	7	.	.	PUNCT
fnp-3801	411	1	hayashi	hayashi	PROPN
fnp-3801	411	2	,	,	PUNCT
fnp-3801	411	3	m.l	m.l	PROPN
fnp-3801	411	4	.	.	PROPN
fnp-3801	411	5	,	,	PUNCT
fnp-3801	411	6	et	et	PROPN
fnp-3801	411	7	al	al	PROPN
fnp-3801	411	8	.	.	PROPN
fnp-3801	411	9	,	,	PUNCT
fnp-3801	411	10	altered	alter	VERB
fnp-3801	411	11	cortical	cortical	ADJ
fnp-3801	411	12	synaptic	synaptic	ADJ
fnp-3801	411	13	morphology	morphology	NOUN
fnp-3801	411	14	and	and	CCONJ
fnp-3801	411	15	impaired	impaired	ADJ
fnp-3801	411	16	memory	memory	NOUN
fnp-3801	411	17	consolidation	consolidation	NOUN
fnp-3801	411	18	in	in	ADP
fnp-3801	411	19	forebrainspecific	forebrainspecific	ADJ
fnp-3801	411	20	dominant	dominant	ADJ
fnp-3801	411	21	-	-	PUNCT
fnp-3801	411	22	negative	negative	ADJ
fnp-3801	411	23	pak	pak	NOUN
fnp-3801	411	24	transgenic	transgenic	NOUN
fnp-3801	411	25	mice	mouse	NOUN
fnp-3801	411	26	.	.	PUNCT
fnp-3801	412	1	neuron	neuron	PROPN
fnp-3801	412	2	,	,	PUNCT
fnp-3801	412	3	2004	2004	NUM
fnp-3801	412	4	.	.	PUNCT
fnp-3801	413	1	42(5	42(5	NOUN
fnp-3801	413	2	):	):	PUNCT
fnp-3801	413	3	p.	p.	NOUN
fnp-3801	413	4	773	773	NUM
fnp-3801	413	5	-	-	SYM
fnp-3801	413	6	87	87	NUM
fnp-3801	413	7	.	.	PUNCT
fnp-3801	414	1	castillon	castillon	NOUN
fnp-3801	414	2	,	,	PUNCT
fnp-3801	414	3	c.	c.	PROPN
fnp-3801	414	4	,	,	PUNCT
fnp-3801	414	5	et	et	PROPN
fnp-3801	414	6	al	al	PROPN
fnp-3801	414	7	.	.	PROPN
fnp-3801	414	8	,	,	PUNCT
fnp-3801	414	9	the	the	DET
fnp-3801	414	10	intellectual	intellectual	ADJ
fnp-3801	414	11	disability	disability	NOUN
fnp-3801	414	12	pak3	pak3	NOUN
fnp-3801	414	13	r67c	r67c	VERB
fnp-3801	414	14	mutation	mutation	NOUN
fnp-3801	414	15	impacts	impact	VERB
fnp-3801	414	16	cognitive	cognitive	ADJ
fnp-3801	414	17	functions	function	NOUN
fnp-3801	414	18	and	and	CCONJ
fnp-3801	414	19	adult	adult	NOUN
fnp-3801	414	20	hippocampal	hippocampal	ADJ
fnp-3801	414	21	neurogenesis	neurogenesis	NOUN
fnp-3801	414	22	.	.	PUNCT
fnp-3801	415	1	hum	hum	PROPN
fnp-3801	415	2	mol	mol	ADP
fnp-3801	415	3	genet	genet	PROPN
fnp-3801	415	4	,	,	PUNCT
fnp-3801	415	5	2020	2020	NUM
fnp-3801	415	6	.	.	PUNCT
fnp-3801	416	1	29(12	29(12	NUM
fnp-3801	416	2	):	):	PUNCT
fnp-3801	416	3	p.	p.	NOUN
fnp-3801	416	4	1950	1950	NUM
fnp-3801	416	5	-	-	SYM
fnp-3801	416	6	68	68	NUM
fnp-3801	416	7	.	.	PUNCT
fnp-3801	417	1	dong	dong	PROPN
fnp-3801	417	2	,	,	PUNCT
fnp-3801	417	3	t.	t.	PROPN
fnp-3801	417	4	,	,	PUNCT
fnp-3801	417	5	et	et	PROPN
fnp-3801	417	6	al	al	PROPN
fnp-3801	417	7	.	.	PROPN
fnp-3801	417	8	,	,	PUNCT
fnp-3801	417	9	inability	inability	NOUN
fnp-3801	417	10	to	to	PART
fnp-3801	417	11	activate	activate	VERB
fnp-3801	417	12	rac1	rac1	NOUN
fnp-3801	417	13	-	-	PUNCT
fnp-3801	417	14	dependent	dependent	ADJ
fnp-3801	417	15	forgetting	forgetting	NOUN
fnp-3801	417	16	contributes	contribute	VERB
fnp-3801	417	17	to	to	ADP
fnp-3801	417	18	behavioral	behavioral	ADJ
fnp-3801	417	19	inflexibility	inflexibility	NOUN
fnp-3801	417	20	in	in	ADP
fnp-3801	417	21	mutants	mutant	NOUN
fnp-3801	417	22	of	of	ADP
fnp-3801	417	23	multiple	multiple	ADJ
fnp-3801	417	24	autism	autism	NOUN
fnp-3801	417	25	-	-	PUNCT
fnp-3801	417	26	risk	risk	NOUN
fnp-3801	417	27	genes	gene	NOUN
fnp-3801	417	28	.	.	PUNCT
fnp-3801	418	1	proc	proc	PROPN
fnp-3801	418	2	natl	natl	PROPN
fnp-3801	418	3	acad	acad	PROPN
fnp-3801	418	4	sci	sci	PROPN
fnp-3801	418	5	u	u	PROPN
fnp-3801	418	6	s	s	PROPN
fnp-3801	418	7	a	a	PRON
fnp-3801	418	8	,	,	PUNCT
fnp-3801	418	9	2016	2016	NUM
fnp-3801	418	10	.	.	PUNCT
fnp-3801	419	1	113(27	113(27	NUM
fnp-3801	419	2	):	):	PUNCT
fnp-3801	420	1	p.	p.	NOUN
fnp-3801	420	2	7644	7644	NUM
fnp-3801	420	3	-	-	SYM
fnp-3801	420	4	9	9	NUM
fnp-3801	420	5	.	.	PUNCT
fnp-3801	420	6	ryan	ryan	PROPN
fnp-3801	420	7	,	,	PUNCT
fnp-3801	420	8	t.j	t.j	PROPN
fnp-3801	420	9	.	.	PROPN
fnp-3801	420	10	,	,	PUNCT
fnp-3801	420	11	et	et	PROPN
fnp-3801	420	12	al	al	PROPN
fnp-3801	420	13	.	.	PROPN
fnp-3801	420	14	,	,	PUNCT
fnp-3801	420	15	memory	memory	NOUN
fnp-3801	420	16	.	.	PUNCT
fnp-3801	421	1	engram	engram	PROPN
fnp-3801	421	2	cells	cell	NOUN
fnp-3801	421	3	retain	retain	VERB
fnp-3801	421	4	memory	memory	NOUN
fnp-3801	421	5	under	under	ADP
fnp-3801	421	6	retrograde	retrograde	ADJ
fnp-3801	421	7	amnesia	amnesia	NOUN
fnp-3801	421	8	.	.	PUNCT
fnp-3801	422	1	science	science	NOUN
fnp-3801	422	2	,	,	PUNCT
fnp-3801	422	3	2015	2015	NUM
fnp-3801	422	4	.	.	PUNCT
fnp-3801	423	1	348(6238	348(6238	NUM
fnp-3801	423	2	):	):	PUNCT
fnp-3801	423	3	p.	p.	NOUN
fnp-3801	423	4	1007	1007	NUM
fnp-3801	423	5	-	-	SYM
fnp-3801	423	6	13	13	NUM
fnp-3801	423	7	.	.	PUNCT
fnp-3801	424	1	ramirez	ramirez	PROPN
fnp-3801	424	2	,	,	PUNCT
fnp-3801	424	3	s.	s.	PROPN
fnp-3801	424	4	,	,	PUNCT
fnp-3801	424	5	et	et	PROPN
fnp-3801	424	6	al	al	PROPN
fnp-3801	424	7	.	.	PROPN
fnp-3801	424	8	,	,	PUNCT
fnp-3801	424	9	creating	create	VERB
fnp-3801	424	10	a	a	DET
fnp-3801	424	11	false	false	ADJ
fnp-3801	424	12	memory	memory	NOUN
fnp-3801	424	13	in	in	ADP
fnp-3801	424	14	the	the	DET
fnp-3801	424	15	hippocampus	hippocampus	NOUN
fnp-3801	424	16	.	.	PUNCT
fnp-3801	425	1	science	science	NOUN
fnp-3801	425	2	,	,	PUNCT
fnp-3801	425	3	2013	2013	NUM
fnp-3801	425	4	.	.	PUNCT
fnp-3801	426	1	341(6144	341(6144	NUM
fnp-3801	426	2	):	):	PUNCT
fnp-3801	426	3	p.	p.	NOUN
fnp-3801	426	4	387	387	NUM
fnp-3801	426	5	-	-	SYM
fnp-3801	426	6	91	91	NUM
fnp-3801	426	7	.	.	PUNCT
fnp-3801	427	1	zhou	zhou	PROPN
fnp-3801	427	2	,	,	PUNCT
fnp-3801	427	3	s.	s.	PROPN
fnp-3801	427	4	and	and	CCONJ
fnp-3801	427	5	z.	z.	PROPN
fnp-3801	427	6	jia	jia	PROPN
fnp-3801	427	7	,	,	PUNCT
fnp-3801	427	8	disruption	disruption	NOUN
fnp-3801	427	9	of	of	ADP
fnp-3801	427	10	pak3	pak3	NOUN
fnp-3801	427	11	signaling	signal	VERB
fnp-3801	427	12	in	in	ADP
fnp-3801	427	13	social	social	ADJ
fnp-3801	427	14	interaction	interaction	NOUN
fnp-3801	427	15	induced	induce	VERB
fnp-3801	427	16	cfos	cfos	PROPN
fnp-3801	427	17	positive	positive	ADJ
fnp-3801	427	18	cells	cell	NOUN
fnp-3801	427	19	impairs	impair	VERB
fnp-3801	427	20	social	social	ADJ
fnp-3801	427	21	recognition	recognition	NOUN
fnp-3801	427	22	memory	memory	NOUN
fnp-3801	427	23	.	.	PUNCT
fnp-3801	428	1	cells	cell	NOUN
fnp-3801	428	2	,	,	PUNCT
fnp-3801	428	3	2021	2021	NUM
fnp-3801	428	4	.	.	PUNCT
fnp-3801	429	1	10(11	10(11	NUM
fnp-3801	429	2	):	):	PUNCT
fnp-3801	429	3	p.	p.	NOUN
fnp-3801	429	4	3010	3010	NUM
fnp-3801	429	5	.	.	PUNCT
fnp-3801	430	1	reijmers	reijmer	NOUN
fnp-3801	430	2	,	,	PUNCT
fnp-3801	430	3	l.g	l.g	PROPN
fnp-3801	430	4	.	.	PROPN
fnp-3801	430	5	,	,	PUNCT
fnp-3801	430	6	et	et	PROPN
fnp-3801	430	7	al	al	PROPN
fnp-3801	430	8	.	.	PROPN
fnp-3801	430	9	,	,	PUNCT
fnp-3801	430	10	localization	localization	NOUN
fnp-3801	430	11	of	of	ADP
fnp-3801	430	12	a	a	DET
fnp-3801	430	13	stable	stable	ADJ
fnp-3801	430	14	neural	neural	ADJ
fnp-3801	430	15	correlate	correlate	NOUN
fnp-3801	430	16	of	of	ADP
fnp-3801	430	17	associative	associative	ADJ
fnp-3801	430	18	memory	memory	NOUN
fnp-3801	430	19	.	.	PUNCT
fnp-3801	431	1	science	science	NOUN
fnp-3801	431	2	,	,	PUNCT
fnp-3801	431	3	2007	2007	NUM
fnp-3801	431	4	.	.	PUNCT
fnp-3801	432	1	317(5842	317(5842	NUM
fnp-3801	432	2	):	):	PUNCT
fnp-3801	433	1	p.	p.	NOUN
fnp-3801	433	2	1230	1230	NUM
fnp-3801	433	3	-	-	SYM
fnp-3801	433	4	3	3	NUM
fnp-3801	433	5	.	.	X
fnp-3801	434	1	voineagu	voineagu	PROPN
fnp-3801	434	2	,	,	PUNCT
fnp-3801	434	3	i.	i.	PROPN
fnp-3801	434	4	,	,	PUNCT
fnp-3801	434	5	et	et	PROPN
fnp-3801	434	6	al	al	PROPN
fnp-3801	434	7	.	.	PROPN
fnp-3801	434	8	,	,	PUNCT
fnp-3801	434	9	transcriptomic	transcriptomic	ADJ
fnp-3801	434	10	analysis	analysis	NOUN
fnp-3801	434	11	of	of	ADP
fnp-3801	434	12	autistic	autistic	ADJ
fnp-3801	434	13	brain	brain	NOUN
fnp-3801	434	14	reveals	reveal	VERB
fnp-3801	434	15	convergent	convergent	ADJ
fnp-3801	434	16	molecular	molecular	ADJ
fnp-3801	434	17	pathology	pathology	NOUN
fnp-3801	434	18	.	.	PUNCT
fnp-3801	435	1	nature	nature	NOUN
fnp-3801	435	2	,	,	PUNCT
fnp-3801	435	3	2011	2011	NUM
fnp-3801	435	4	.	.	PUNCT
fnp-3801	436	1	474(7351	474(7351	NUM
fnp-3801	436	2	):	):	PUNCT
fnp-3801	437	1	p.	p.	NOUN
fnp-3801	437	2	380	380	NUM
fnp-3801	437	3	-	-	SYM
fnp-3801	437	4	4	4	NUM
fnp-3801	437	5	.	.	PUNCT
fnp-3801	438	1	edmonson	edmonson	PROPN
fnp-3801	438	2	,	,	PUNCT
fnp-3801	438	3	c.	c.	PROPN
fnp-3801	438	4	,	,	PUNCT
fnp-3801	438	5	m.n	m.n	PROPN
fnp-3801	438	6	.	.	PROPN
fnp-3801	438	7	ziats	ziat	NOUN
fnp-3801	438	8	,	,	PUNCT
fnp-3801	438	9	and	and	CCONJ
fnp-3801	438	10	o.m	o.m	PROPN
fnp-3801	438	11	.	.	PROPN
fnp-3801	438	12	rennert	rennert	PROPN
fnp-3801	438	13	,	,	PUNCT
fnp-3801	438	14	altered	alter	VERB
fnp-3801	438	15	glial	glial	ADJ
fnp-3801	438	16	marker	marker	NOUN
fnp-3801	438	17	expression	expression	NOUN
fnp-3801	438	18	in	in	ADP
fnp-3801	438	19	autistic	autistic	ADJ
fnp-3801	438	20	post	post	ADJ
fnp-3801	438	21	-	-	ADJ
fnp-3801	438	22	mortem	mortem	ADJ
fnp-3801	438	23	prefrontal	prefrontal	ADJ
fnp-3801	438	24	cortex	cortex	NOUN
fnp-3801	438	25	and	and	CCONJ
fnp-3801	438	26	cerebellum	cerebellum	ADJ
fnp-3801	438	27	.	.	PUNCT
fnp-3801	439	1	mol	mol	ADP
fnp-3801	439	2	autism	autism	NOUN
fnp-3801	439	3	,	,	PUNCT
fnp-3801	439	4	2014	2014	NUM
fnp-3801	439	5	.	.	PUNCT
fnp-3801	440	1	5(1	5(1	NUM
fnp-3801	440	2	):	):	PUNCT
fnp-3801	440	3	p.	p.	NOUN
fnp-3801	440	4	3	3	NUM
fnp-3801	440	5	.	.	PUNCT
fnp-3801	441	1	russo	russo	PROPN
fnp-3801	441	2	,	,	PUNCT
fnp-3801	441	3	f.b	f.b	PROPN
fnp-3801	441	4	.	.	PROPN
fnp-3801	441	5	,	,	PUNCT
fnp-3801	441	6	et	et	PROPN
fnp-3801	441	7	al	al	PROPN
fnp-3801	441	8	.	.	PROPN
fnp-3801	441	9	,	,	PUNCT
fnp-3801	441	10	modeling	model	VERB
fnp-3801	441	11	the	the	DET
fnp-3801	441	12	interplay	interplay	NOUN
fnp-3801	441	13	between	between	ADP
fnp-3801	441	14	neurons	neuron	NOUN
fnp-3801	441	15	and	and	CCONJ
fnp-3801	441	16	astrocytes	astrocyte	NOUN
fnp-3801	441	17	in	in	ADP
fnp-3801	441	18	autism	autism	NOUN
fnp-3801	441	19	using	use	VERB
fnp-3801	441	20	human	human	ADJ
fnp-3801	441	21	induced	induced	ADJ
fnp-3801	441	22	pluripotent	pluripotent	ADJ
fnp-3801	441	23	stem	stem	NOUN
fnp-3801	441	24	cells	cell	NOUN
fnp-3801	441	25	.	.	PUNCT
fnp-3801	442	1	biol	biol	PROPN
fnp-3801	442	2	psychiatry	psychiatry	NOUN
fnp-3801	442	3	,	,	PUNCT
fnp-3801	442	4	2018	2018	NUM
fnp-3801	442	5	.	.	PUNCT
fnp-3801	443	1	83(7	83(7	NUM
fnp-3801	443	2	):	):	PUNCT
fnp-3801	443	3	p.	p.	NOUN
fnp-3801	443	4	569	569	NUM
fnp-3801	443	5	-	-	SYM
fnp-3801	443	6	78	78	NUM
fnp-3801	443	7	.	.	PUNCT
fnp-3801	444	1	allen	allen	PROPN
fnp-3801	444	2	,	,	PUNCT
fnp-3801	444	3	m.	m.	NOUN
fnp-3801	444	4	,	,	PUNCT
fnp-3801	444	5	et	et	PROPN
fnp-3801	444	6	al	al	PROPN
fnp-3801	444	7	.	.	PROPN
fnp-3801	444	8	,	,	PUNCT
fnp-3801	444	9	astrocytes	astrocyte	NOUN
fnp-3801	444	10	derived	derive	VERB
fnp-3801	444	11	from	from	ADP
fnp-3801	444	12	asd	asd	PROPN
fnp-3801	444	13	patients	patient	NOUN
fnp-3801	444	14	alter	alter	VERB
fnp-3801	444	15	behavior	behavior	NOUN
fnp-3801	444	16	and	and	CCONJ
fnp-3801	444	17	destabilize	destabilize	VERB
fnp-3801	444	18	neuronal	neuronal	ADJ
fnp-3801	444	19	activity	activity	NOUN
fnp-3801	444	20	through	through	ADP
fnp-3801	444	21	aberrant	aberrant	ADJ
fnp-3801	444	22	ca2	ca2	PROPN
fnp-3801	444	23	+	+	PROPN
fnp-3801	444	24	signaling	signal	VERB
fnp-3801	444	25	.	.	PUNCT
fnp-3801	445	1	biorxiv	biorxiv	NOUN
fnp-3801	445	2	,	,	PUNCT
fnp-3801	445	3	2021	2021	NUM
fnp-3801	445	4	..	..	PUNCT
fnp-3801	446	1	gilman	gilman	PROPN
fnp-3801	446	2	,	,	PUNCT
fnp-3801	446	3	s.r	s.r	PROPN
fnp-3801	446	4	.	.	PROPN
fnp-3801	446	5	,	,	PUNCT
fnp-3801	446	6	et	et	PROPN
fnp-3801	446	7	al	al	PROPN
fnp-3801	446	8	.	.	PROPN
fnp-3801	446	9	,	,	PUNCT
fnp-3801	446	10	rare	rare	ADJ
fnp-3801	446	11	de	de	PROPN
fnp-3801	446	12	novo	novo	NOUN
fnp-3801	446	13	variants	variant	NOUN
fnp-3801	446	14	associated	associate	VERB
fnp-3801	446	15	with	with	ADP
fnp-3801	446	16	autism	autism	NOUN
fnp-3801	446	17	implicate	implicate	VERB
fnp-3801	446	18	a	a	DET
fnp-3801	446	19	large	large	ADJ
fnp-3801	446	20	functional	functional	ADJ
fnp-3801	446	21	network	network	NOUN
fnp-3801	446	22	of	of	ADP
fnp-3801	446	23	genes	gene	NOUN
fnp-3801	446	24	involved	involve	VERB
fnp-3801	446	25	in	in	ADP
fnp-3801	446	26	formation	formation	NOUN
fnp-3801	446	27	and	and	CCONJ
fnp-3801	446	28	function	function	NOUN
fnp-3801	446	29	of	of	ADP
fnp-3801	446	30	synapses	synapsis	NOUN
fnp-3801	446	31	.	.	PUNCT
fnp-3801	447	1	neuron	neuron	PROPN
fnp-3801	447	2	,	,	PUNCT
fnp-3801	447	3	2011	2011	NUM
fnp-3801	447	4	.	.	PUNCT
fnp-3801	448	1	70(5	70(5	NUM
fnp-3801	448	2	):	):	PUNCT
fnp-3801	448	3	p.	p.	NOUN
fnp-3801	448	4	898	898	NUM
fnp-3801	448	5	-	-	SYM
fnp-3801	448	6	907	907	NUM
fnp-3801	448	7	.	.	PUNCT
fnp-3801	449	1	srinivasan	srinivasan	NOUN
fnp-3801	449	2	,	,	PUNCT
fnp-3801	449	3	r.	r.	PROPN
fnp-3801	449	4	,	,	PUNCT
fnp-3801	449	5	et	et	PROPN
fnp-3801	449	6	al	al	PROPN
fnp-3801	449	7	.	.	PROPN
fnp-3801	449	8	,	,	PUNCT
fnp-3801	449	9	ca(2	ca(2	NOUN
fnp-3801	449	10	+	+	NOUN
fnp-3801	449	11	)	)	PUNCT
fnp-3801	449	12	signaling	signal	VERB
fnp-3801	449	13	in	in	ADP
fnp-3801	449	14	astrocytes	astrocyte	NOUN
fnp-3801	449	15	from	from	ADP
fnp-3801	449	16	ip3r2(-/-	ip3r2(-/-	NOUN
fnp-3801	449	17	)	)	PUNCT
fnp-3801	449	18	mice	mouse	NOUN
fnp-3801	449	19	in	in	ADP
fnp-3801	449	20	brain	brain	NOUN
fnp-3801	449	21	slices	slice	NOUN
fnp-3801	449	22	and	and	CCONJ
fnp-3801	449	23	during	during	ADP
fnp-3801	449	24	startle	startle	ADJ
fnp-3801	449	25	responses	response	NOUN
fnp-3801	449	26	in	in	ADP
fnp-3801	449	27	vivo	vivo	NOUN
fnp-3801	449	28	.	.	PUNCT
fnp-3801	450	1	nat	nat	PROPN
fnp-3801	450	2	neurosci	neurosci	PROPN
fnp-3801	450	3	,	,	PUNCT
fnp-3801	450	4	2015	2015	NUM
fnp-3801	450	5	.	.	PUNCT
fnp-3801	451	1	18(5	18(5	NUM
fnp-3801	451	2	):	):	PUNCT
fnp-3801	452	1	p.	p.	NOUN
fnp-3801	452	2	708	708	NUM
fnp-3801	452	3	-	-	SYM
fnp-3801	452	4	17	17	NUM
fnp-3801	452	5	.	.	PUNCT
fnp-3801	453	1	petravicz	petravicz	NOUN
fnp-3801	453	2	,	,	PUNCT
fnp-3801	453	3	j.	j.	PROPN
fnp-3801	453	4	,	,	PUNCT
fnp-3801	453	5	et	et	PROPN
fnp-3801	453	6	al	al	PROPN
fnp-3801	453	7	.	.	PROPN
fnp-3801	453	8	,	,	PUNCT
fnp-3801	453	9	loss	loss	NOUN
fnp-3801	453	10	of	of	ADP
fnp-3801	453	11	ip3	ip3	NOUN
fnp-3801	453	12	receptor	receptor	NOUN
fnp-3801	453	13	-	-	PUNCT
fnp-3801	453	14	dependent	dependent	ADJ
fnp-3801	453	15	ca2	ca2	PROPN
fnp-3801	453	16	+	+	NOUN
fnp-3801	453	17	increases	increase	NOUN
fnp-3801	453	18	in	in	ADP
fnp-3801	453	19	hippocampal	hippocampal	ADJ
fnp-3801	453	20	astrocytes	astrocyte	NOUN
fnp-3801	453	21	does	do	AUX
fnp-3801	453	22	not	not	PART
fnp-3801	453	23	affect	affect	VERB
fnp-3801	453	24	baseline	baseline	NOUN
fnp-3801	453	25	ca1	ca1	PROPN
fnp-3801	453	26	pyramidal	pyramidal	ADJ
fnp-3801	453	27	neuron	neuron	NOUN
fnp-3801	453	28	synaptic	synaptic	ADJ
fnp-3801	453	29	activity	activity	NOUN
fnp-3801	453	30	.	.	PUNCT
fnp-3801	454	1	j	j	PROPN
fnp-3801	454	2	neurosci	neurosci	PROPN
fnp-3801	454	3	,	,	PUNCT
fnp-3801	454	4	2008	2008	NUM
fnp-3801	454	5	.	.	PUNCT
fnp-3801	455	1	28(19	28(19	NUM
fnp-3801	455	2	):	):	PUNCT
fnp-3801	456	1	p.	p.	NOUN
fnp-3801	456	2	4967	4967	NUM
fnp-3801	456	3	-	-	SYM
fnp-3801	456	4	73	73	NUM
fnp-3801	456	5	.	.	PUNCT
fnp-3801	457	1	wang	wang	PROPN
fnp-3801	457	2	,	,	PUNCT
fnp-3801	457	3	q.	q.	PROPN
fnp-3801	457	4	,	,	PUNCT
fnp-3801	457	5	et	et	PROPN
fnp-3801	457	6	al	al	PROPN
fnp-3801	457	7	.	.	PROPN
fnp-3801	457	8	,	,	PUNCT
fnp-3801	457	9	impaired	impaired	ADJ
fnp-3801	457	10	calcium	calcium	NOUN
fnp-3801	457	11	signaling	signal	VERB
fnp-3801	457	12	in	in	ADP
fnp-3801	457	13	astrocytes	astrocyte	NOUN
fnp-3801	457	14	modulates	modulate	VERB
fnp-3801	457	15	autism	autism	NOUN
fnp-3801	457	16	spectrum	spectrum	NOUN
fnp-3801	457	17	disorder	disorder	NOUN
fnp-3801	457	18	-	-	PUNCT
fnp-3801	457	19	like	like	ADJ
fnp-3801	457	20	behaviors	behavior	NOUN
fnp-3801	457	21	in	in	ADP
fnp-3801	457	22	mice	mouse	NOUN
fnp-3801	457	23	.	.	PUNCT
fnp-3801	458	1	nat	nat	PROPN
fnp-3801	458	2	commun	commun	PROPN
fnp-3801	458	3	,	,	PUNCT
fnp-3801	458	4	2021	2021	NUM
fnp-3801	458	5	.	.	PUNCT
fnp-3801	459	1	12(1	12(1	NUM
fnp-3801	459	2	):	):	PUNCT
fnp-3801	459	3	p.	p.	NOUN
fnp-3801	459	4	3321	3321	NUM
fnp-3801	459	5	.	.	PUNCT
fnp-3801	460	1	traetta	traetta	NOUN
fnp-3801	460	2	,	,	PUNCT
fnp-3801	460	3	m.e	m.e	PROPN
fnp-3801	460	4	.	.	PROPN
fnp-3801	460	5	,	,	PUNCT
fnp-3801	460	6	et	et	PROPN
fnp-3801	460	7	al	al	PROPN
fnp-3801	460	8	.	.	PROPN
fnp-3801	460	9	,	,	PUNCT
fnp-3801	460	10	long	long	ADV
fnp-3801	460	11	-	-	PUNCT
fnp-3801	460	12	lasting	last	VERB
fnp-3801	460	13	changes	change	NOUN
fnp-3801	460	14	in	in	ADP
fnp-3801	460	15	glial	glial	ADJ
fnp-3801	460	16	cells	cell	NOUN
fnp-3801	460	17	isolated	isolate	VERB
fnp-3801	460	18	from	from	ADP
fnp-3801	460	19	rats	rat	NOUN
fnp-3801	460	20	subjected	subject	VERB
fnp-3801	460	21	to	to	ADP
fnp-3801	460	22	the	the	DET
fnp-3801	460	23	valproic	valproic	ADJ
fnp-3801	460	24	acid	acid	NOUN
fnp-3801	460	25	model	model	NOUN
fnp-3801	460	26	of	of	ADP
fnp-3801	460	27	autism	autism	NOUN
fnp-3801	460	28	spectrum	spectrum	NOUN
fnp-3801	460	29	disorder	disorder	NOUN
fnp-3801	460	30	.	.	PUNCT
fnp-3801	461	1	front	front	ADJ
fnp-3801	461	2	pharmacol	pharmacol	PROPN
fnp-3801	461	3	,	,	PUNCT
fnp-3801	461	4	2021	2021	NUM
fnp-3801	461	5	.	.	PUNCT
fnp-3801	462	1	12	12	NUM
fnp-3801	462	2	:	:	PUNCT
fnp-3801	463	1	p.	p.	NOUN
fnp-3801	463	2	707859	707859	NUM
fnp-3801	463	3	.	.	PUNCT
fnp-3801	464	1	hannan	hannan	PROPN
fnp-3801	464	2	,	,	PUNCT
fnp-3801	464	3	a.j	a.j	PROPN
fnp-3801	464	4	.	.	PROPN
fnp-3801	464	5	,	,	PUNCT
fnp-3801	464	6	tandem	tandem	VERB
fnp-3801	464	7	repeats	repeat	NOUN
fnp-3801	464	8	and	and	CCONJ
fnp-3801	464	9	repeatomes	repeatome	NOUN
fnp-3801	464	10	:	:	PUNCT
fnp-3801	464	11	delving	delve	VERB
fnp-3801	464	12	deeper	deep	ADJ
fnp-3801	464	13	into	into	ADP
fnp-3801	464	14	the	the	DET
fnp-3801	464	15	'	'	PUNCT
fnp-3801	464	16	dark	dark	ADJ
fnp-3801	464	17	matter	matter	NOUN
fnp-3801	464	18	'	'	PUNCT
fnp-3801	464	19	of	of	ADP
fnp-3801	464	20	genomes	genome	NOUN
fnp-3801	464	21	.	.	PUNCT
fnp-3801	465	1	ebiomedicine	ebiomedicine	ADJ
fnp-3801	465	2	,	,	PUNCT
fnp-3801	465	3	2018	2018	NUM
fnp-3801	465	4	.	.	PUNCT
fnp-3801	466	1	31	31	NUM
fnp-3801	466	2	:	:	PUNCT
fnp-3801	467	1	p.	p.	NOUN
fnp-3801	467	2	3	3	NUM
fnp-3801	467	3	-	-	SYM
fnp-3801	467	4	4	4	NUM
fnp-3801	467	5	.	.	PUNCT
fnp-3801	468	1	hannan	hannan	PROPN
fnp-3801	468	2	,	,	PUNCT
fnp-3801	468	3	a.j	a.j	PROPN
fnp-3801	468	4	.	.	PROPN
fnp-3801	468	5	,	,	PUNCT
fnp-3801	468	6	tandem	tandem	NOUN
fnp-3801	468	7	repeats	repeat	NOUN
fnp-3801	468	8	mediating	mediate	VERB
fnp-3801	468	9	genetic	genetic	ADJ
fnp-3801	468	10	plasticity	plasticity	NOUN
fnp-3801	468	11	in	in	ADP
fnp-3801	468	12	health	health	NOUN
fnp-3801	468	13	and	and	CCONJ
fnp-3801	468	14	disease	disease	NOUN
fnp-3801	468	15	.	.	PUNCT
fnp-3801	469	1	nat	nat	PROPN
fnp-3801	469	2	rev	rev	PROPN
fnp-3801	469	3	genet	genet	PROPN
fnp-3801	469	4	,	,	PUNCT
fnp-3801	469	5	2018	2018	NUM
fnp-3801	469	6	.	.	PUNCT
fnp-3801	470	1	19(5	19(5	X
fnp-3801	470	2	):	):	PUNCT
fnp-3801	470	3	p.	p.	NOUN
fnp-3801	470	4	286	286	NUM
fnp-3801	470	5	-	-	SYM
fnp-3801	470	6	98	98	NUM
fnp-3801	470	7	.	.	PUNCT
fnp-3801	471	1	schaaf	schaaf	PROPN
fnp-3801	471	2	,	,	PUNCT
fnp-3801	471	3	c.p	c.p	PROPN
fnp-3801	471	4	.	.	PROPN
fnp-3801	471	5	,	,	PUNCT
fnp-3801	471	6	et	et	PROPN
fnp-3801	471	7	al	al	PROPN
fnp-3801	471	8	.	.	PROPN
fnp-3801	471	9	,	,	PUNCT
fnp-3801	471	10	a	a	DET
fnp-3801	471	11	framework	framework	NOUN
fnp-3801	471	12	for	for	ADP
fnp-3801	471	13	an	an	DET
fnp-3801	471	14	evidence	evidence	NOUN
fnp-3801	471	15	-	-	PUNCT
fnp-3801	471	16	based	base	VERB
fnp-3801	471	17	gene	gene	NOUN
fnp-3801	471	18	list	list	NOUN
fnp-3801	471	19	relevant	relevant	ADJ
fnp-3801	471	20	to	to	ADP
fnp-3801	471	21	autism	autism	NOUN
fnp-3801	471	22	spectrum	spectrum	NOUN
fnp-3801	471	23	disorder	disorder	NOUN
fnp-3801	471	24	.	.	PUNCT
fnp-3801	472	1	nat	nat	PROPN
fnp-3801	472	2	rev	rev	PROPN
fnp-3801	472	3	genet	genet	PROPN
fnp-3801	472	4	,	,	PUNCT
fnp-3801	472	5	2020	2020	NUM
fnp-3801	472	6	.	.	PUNCT
fnp-3801	473	1	21(6	21(6	NUM
fnp-3801	473	2	):	):	PUNCT
fnp-3801	474	1	p.	p.	NOUN
fnp-3801	474	2	367	367	NUM
fnp-3801	474	3	-	-	SYM
fnp-3801	474	4	76	76	NUM
fnp-3801	474	5	.	.	PUNCT
fnp-3801	475	1	mitra	mitra	PROPN
fnp-3801	475	2	,	,	PUNCT
fnp-3801	475	3	i.	i.	PROPN
fnp-3801	475	4	,	,	PUNCT
fnp-3801	475	5	et	et	PROPN
fnp-3801	475	6	al	al	PROPN
fnp-3801	475	7	.	.	PROPN
fnp-3801	475	8	,	,	PUNCT
fnp-3801	475	9	patterns	pattern	NOUN
fnp-3801	475	10	of	of	ADP
fnp-3801	475	11	de	de	X
fnp-3801	475	12	novo	novo	PROPN
fnp-3801	475	13	tandem	tandem	PROPN
fnp-3801	475	14	repeat	repeat	NOUN
fnp-3801	475	15	mutations	mutation	NOUN
fnp-3801	475	16	and	and	CCONJ
fnp-3801	475	17	their	their	PRON
fnp-3801	475	18	role	role	NOUN
fnp-3801	475	19	in	in	ADP
fnp-3801	475	20	autism	autism	NOUN
fnp-3801	475	21	.	.	PUNCT
fnp-3801	476	1	nature	nature	NOUN
fnp-3801	476	2	,	,	PUNCT
fnp-3801	476	3	2021	2021	NUM
fnp-3801	476	4	.	.	PUNCT
fnp-3801	477	1	589(7841	589(7841	NUM
fnp-3801	477	2	):	):	PUNCT
fnp-3801	478	1	p.	p.	NOUN
fnp-3801	478	2	246	246	NUM
fnp-3801	478	3	-	-	SYM
fnp-3801	478	4	50	50	NUM
fnp-3801	478	5	.	.	PUNCT
fnp-3801	479	1	trost	trost	PROPN
fnp-3801	479	2	,	,	PUNCT
fnp-3801	479	3	b.	b.	PROPN
fnp-3801	479	4	,	,	PUNCT
fnp-3801	479	5	et	et	PROPN
fnp-3801	479	6	al	al	PROPN
fnp-3801	479	7	.	.	PROPN
fnp-3801	479	8	,	,	PUNCT
fnp-3801	479	9	genome	genome	NOUN
fnp-3801	479	10	-	-	PUNCT
fnp-3801	479	11	wide	wide	ADJ
fnp-3801	479	12	detection	detection	NOUN
fnp-3801	479	13	of	of	ADP
fnp-3801	479	14	tandem	tandem	PROPN
fnp-3801	479	15	dna	dna	PROPN
fnp-3801	479	16	repeats	repeat	NOUN
fnp-3801	479	17	that	that	PRON
fnp-3801	479	18	are	be	AUX
fnp-3801	479	19	expanded	expand	VERB
fnp-3801	479	20	in	in	ADP
fnp-3801	479	21	autism	autism	NOUN
fnp-3801	479	22	.	.	PUNCT
fnp-3801	480	1	nature	nature	NOUN
fnp-3801	480	2	,	,	PUNCT
fnp-3801	480	3	2020	2020	NUM
fnp-3801	480	4	.	.	PUNCT
fnp-3801	481	1	586(7827	586(7827	NUM
fnp-3801	481	2	):	):	PUNCT
fnp-3801	482	1	p.	p.	NOUN
fnp-3801	482	2	80	80	NUM
fnp-3801	482	3	-	-	SYM
fnp-3801	482	4	6	6	NUM
fnp-3801	482	5	.	.	PUNCT
fnp-3801	483	1	sokpor	sokpor	PROPN
fnp-3801	483	2	,	,	PUNCT
fnp-3801	483	3	g.	g.	PROPN
fnp-3801	483	4	,	,	PUNCT
fnp-3801	483	5	et	et	PROPN
fnp-3801	483	6	al	al	PROPN
fnp-3801	483	7	.	.	PROPN
fnp-3801	483	8	,	,	PUNCT
fnp-3801	483	9	chromatin	chromatin	NOUN
fnp-3801	483	10	remodeling	remodeling	NOUN
fnp-3801	483	11	baf	baf	PROPN
fnp-3801	483	12	(	(	PUNCT
fnp-3801	483	13	swi	swi	PROPN
fnp-3801	483	14	/	/	SYM
fnp-3801	483	15	snf	snf	PROPN
fnp-3801	483	16	)	)	PUNCT
fnp-3801	483	17	complexes	complex	NOUN
fnp-3801	483	18	in	in	ADP
fnp-3801	483	19	neural	neural	ADJ
fnp-3801	483	20	development	development	NOUN
fnp-3801	483	21	and	and	CCONJ
fnp-3801	483	22	disorders	disorder	NOUN
fnp-3801	483	23	.	.	PUNCT
fnp-3801	484	1	front	front	NOUN
fnp-3801	484	2	mol	mol	ADP
fnp-3801	484	3	neurosci	neurosci	PROPN
fnp-3801	484	4	,	,	PUNCT
fnp-3801	484	5	2017	2017	NUM
fnp-3801	484	6	.	.	PUNCT
fnp-3801	485	1	10	10	NUM
fnp-3801	485	2	:	:	PUNCT
fnp-3801	485	3	p.	p.	NOUN
fnp-3801	485	4	243	243	NUM
fnp-3801	485	5	.	.	PUNCT
fnp-3801	486	1	hoyer	hoyer	PROPN
fnp-3801	486	2	,	,	PUNCT
fnp-3801	486	3	j.	j.	PROPN
fnp-3801	486	4	,	,	PUNCT
fnp-3801	486	5	et	et	PROPN
fnp-3801	486	6	al	al	PROPN
fnp-3801	486	7	.	.	PROPN
fnp-3801	486	8	,	,	PUNCT
fnp-3801	486	9	haploinsufficiency	haploinsufficiency	NOUN
fnp-3801	486	10	of	of	ADP
fnp-3801	486	11	arid1b	arid1b	NOUN
fnp-3801	486	12	,	,	PUNCT
fnp-3801	486	13	a	a	DET
fnp-3801	486	14	member	member	NOUN
fnp-3801	486	15	of	of	ADP
fnp-3801	486	16	the	the	DET
fnp-3801	486	17	swi	swi	PROPN
fnp-3801	486	18	/	/	SYM
fnp-3801	486	19	snf	snf	PROPN
fnp-3801	486	20	-	-	PUNCT
fnp-3801	486	21	a	a	DET
fnp-3801	486	22	chromatin	chromatin	NOUN
fnp-3801	486	23	-	-	PUNCT
fnp-3801	486	24	remodeling	remodeling	NOUN
fnp-3801	486	25	complex	complex	NOUN
fnp-3801	486	26	,	,	PUNCT
fnp-3801	486	27	is	be	AUX
fnp-3801	486	28	a	a	DET
fnp-3801	486	29	frequent	frequent	ADJ
fnp-3801	486	30	cause	cause	NOUN
fnp-3801	486	31	of	of	ADP
fnp-3801	486	32	intellectual	intellectual	ADJ
fnp-3801	486	33	disability	disability	NOUN
fnp-3801	486	34	.	.	PUNCT
fnp-3801	487	1	am	be	AUX
fnp-3801	487	2	j	j	PROPN
fnp-3801	487	3	hum	hum	PROPN
fnp-3801	487	4	genet	genet	PROPN
fnp-3801	487	5	,	,	PUNCT
fnp-3801	487	6	2012	2012	NUM
fnp-3801	487	7	.	.	PUNCT
fnp-3801	488	1	90(3	90(3	NOUN
fnp-3801	488	2	):	):	PUNCT
fnp-3801	488	3	p.	p.	NOUN
fnp-3801	488	4	565	565	NUM
fnp-3801	488	5	-	-	SYM
fnp-3801	488	6	72	72	NUM
fnp-3801	488	7	.	.	PUNCT
fnp-3801	489	1	pagliaroli	pagliaroli	PROPN
fnp-3801	489	2	,	,	PUNCT
fnp-3801	489	3	l.	l.	PROPN
fnp-3801	489	4	,	,	PUNCT
fnp-3801	489	5	et	et	PROPN
fnp-3801	489	6	al	al	PROPN
fnp-3801	489	7	.	.	PROPN
fnp-3801	489	8	,	,	PUNCT
fnp-3801	489	9	inability	inability	NOUN
fnp-3801	489	10	to	to	PART
fnp-3801	489	11	switch	switch	VERB
fnp-3801	489	12	from	from	ADP
fnp-3801	489	13	arid1a	arid1a	PROPN
fnp-3801	489	14	-	-	PUNCT
fnp-3801	489	15	baf	baf	PROPN
fnp-3801	489	16	to	to	ADP
fnp-3801	489	17	arid1b	arid1b	NOUN
fnp-3801	489	18	-	-	PUNCT
fnp-3801	489	19	baf	baf	PROPN
fnp-3801	489	20	impairs	impair	VERB
fnp-3801	489	21	exit	exit	NOUN
fnp-3801	489	22	from	from	ADP
fnp-3801	489	23	pluripotency	pluripotency	NOUN
fnp-3801	489	24	and	and	CCONJ
fnp-3801	489	25	commitment	commitment	NOUN
fnp-3801	489	26	towards	towards	ADP
fnp-3801	489	27	neural	neural	ADJ
fnp-3801	489	28	crest	crest	NOUN
fnp-3801	489	29	formation	formation	NOUN
fnp-3801	489	30	in	in	ADP
fnp-3801	489	31	arid1b	arid1b	NOUN
fnp-3801	489	32	-	-	PUNCT
fnp-3801	489	33	related	relate	VERB
fnp-3801	489	34	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	489	35	disorders	disorder	NOUN
fnp-3801	489	36	.	.	PUNCT
fnp-3801	490	1	nat	nat	PROPN
fnp-3801	490	2	commun	commun	PROPN
fnp-3801	490	3	,	,	PUNCT
fnp-3801	490	4	2021	2021	NUM
fnp-3801	490	5	.	.	PUNCT
fnp-3801	491	1	12(1	12(1	NUM
fnp-3801	491	2	):	):	PUNCT
fnp-3801	491	3	p.	p.	NOUN
fnp-3801	491	4	6469	6469	NUM
fnp-3801	491	5	.	.	PUNCT
fnp-3801	492	1	jurkin	jurkin	PROPN
fnp-3801	492	2	,	,	PUNCT
fnp-3801	492	3	j.	j.	PROPN
fnp-3801	492	4	,	,	PUNCT
fnp-3801	492	5	et	et	PROPN
fnp-3801	492	6	al	al	PROPN
fnp-3801	492	7	.	.	PROPN
fnp-3801	492	8	,	,	PUNCT
fnp-3801	492	9	the	the	DET
fnp-3801	492	10	mammalian	mammalian	PROPN
fnp-3801	492	11	trna	trna	PROPN
fnp-3801	492	12	ligase	ligase	PROPN
fnp-3801	492	13	complex	complex	PROPN
fnp-3801	492	14	mediates	mediate	NOUN
fnp-3801	492	15	splicing	splicing	NOUN
fnp-3801	492	16	of	of	ADP
fnp-3801	492	17	xbp1	xbp1	PROPN
fnp-3801	492	18	mrna	mrna	PROPN
fnp-3801	492	19	and	and	CCONJ
fnp-3801	492	20	controls	control	VERB
fnp-3801	492	21	antibody	antibody	NOUN
fnp-3801	492	22	secretion	secretion	NOUN
fnp-3801	492	23	in	in	ADP
fnp-3801	492	24	plasma	plasma	NOUN
fnp-3801	492	25	cells	cell	NOUN
fnp-3801	492	26	.	.	PUNCT
fnp-3801	493	1	embo	embo	PROPN
fnp-3801	493	2	j	j	PROPN
fnp-3801	493	3	,	,	PUNCT
fnp-3801	493	4	2014	2014	NUM
fnp-3801	493	5	.	.	PUNCT
fnp-3801	494	1	33(24	33(24	NUM
fnp-3801	494	2	):	):	PUNCT
fnp-3801	494	3	p.	p.	NOUN
fnp-3801	494	4	2922	2922	NUM
fnp-3801	494	5	-	-	SYM
fnp-3801	494	6	36	36	NUM
fnp-3801	494	7	.	.	PUNCT
fnp-3801	495	1	parenti	parenti	PROPN
fnp-3801	495	2	,	,	PUNCT
fnp-3801	495	3	i.	i.	PROPN
fnp-3801	495	4	,	,	PUNCT
fnp-3801	495	5	et	et	PROPN
fnp-3801	495	6	al	al	PROPN
fnp-3801	495	7	.	.	PROPN
fnp-3801	495	8	,	,	PUNCT
fnp-3801	495	9	neurodevelopmental	neurodevelopmental	ADJ
fnp-3801	495	10	disorders	disorder	NOUN
fnp-3801	495	11	:	:	PUNCT
fnp-3801	495	12	from	from	ADP
fnp-3801	495	13	genetics	genetic	NOUN
fnp-3801	495	14	to	to	ADP
fnp-3801	495	15	functional	functional	ADJ
fnp-3801	495	16	pathways	pathway	NOUN
fnp-3801	495	17	.	.	PUNCT
fnp-3801	496	1	trends	trend	NOUN
fnp-3801	496	2	neurosci	neurosci	PROPN
fnp-3801	496	3	,	,	PUNCT
fnp-3801	496	4	2020	2020	NUM
fnp-3801	496	5	.	.	PUNCT
fnp-3801	497	1	43(8	43(8	NUM
fnp-3801	497	2	):	):	PUNCT
fnp-3801	497	3	p.	p.	NOUN
fnp-3801	497	4	608	608	NUM
fnp-3801	497	5	-	-	SYM
fnp-3801	497	6	21	21	NUM
fnp-3801	497	7	.	.	PUNCT
fnp-3801	498	1	swinehart	swinehart	PROPN
fnp-3801	498	2	,	,	PUNCT
fnp-3801	498	3	w.e	w.e	PROPN
fnp-3801	498	4	.	.	PROPN
fnp-3801	498	5	and	and	CCONJ
fnp-3801	498	6	j.e	j.e	PROPN
fnp-3801	498	7	.	.	PROPN
fnp-3801	498	8	jackman	jackman	PROPN
fnp-3801	498	9	,	,	PUNCT
fnp-3801	498	10	diversity	diversity	NOUN
fnp-3801	498	11	in	in	ADP
fnp-3801	498	12	mechanism	mechanism	NOUN
fnp-3801	498	13	and	and	CCONJ
fnp-3801	498	14	function	function	NOUN
fnp-3801	498	15	of	of	ADP
fnp-3801	498	16	trna	trna	PROPN
fnp-3801	498	17	methyltransferases	methyltransferase	NOUN
fnp-3801	498	18	.	.	PUNCT
fnp-3801	499	1	rna	rna	PROPN
fnp-3801	499	2	biol	biol	PROPN
fnp-3801	499	3	,	,	PUNCT
fnp-3801	499	4	2015	2015	NUM
fnp-3801	499	5	.	.	PUNCT
fnp-3801	500	1	12(4	12(4	NUM
fnp-3801	500	2	):	):	PUNCT
fnp-3801	501	1	p.	p.	NOUN
fnp-3801	501	2	398	398	NUM
fnp-3801	501	3	-	-	SYM
fnp-3801	501	4	411	411	NUM
fnp-3801	501	5	.	.	PUNCT
fnp-3801	502	1	abedini	abedini	PROPN
fnp-3801	502	2	,	,	PUNCT
fnp-3801	502	3	s.s	s.s	PROPN
fnp-3801	502	4	.	.	PROPN
fnp-3801	502	5	,	,	PUNCT
fnp-3801	502	6	et	et	PROPN
fnp-3801	502	7	al	al	PROPN
fnp-3801	502	8	.	.	PROPN
fnp-3801	502	9	,	,	PUNCT
fnp-3801	502	10	trna	trna	NOUN
fnp-3801	502	11	methyltransferase	methyltransferase	NOUN
fnp-3801	502	12	defects	defect	NOUN
fnp-3801	502	13	and	and	CCONJ
fnp-3801	502	14	intellectual	intellectual	ADJ
fnp-3801	502	15	disability	disability	NOUN
fnp-3801	502	16	.	.	PUNCT
fnp-3801	503	1	arch	arch	PROPN
fnp-3801	503	2	iran	iran	PROPN
fnp-3801	503	3	med	me	VERB
fnp-3801	503	4	,	,	PUNCT
fnp-3801	503	5	2018	2018	NUM
fnp-3801	503	6	.	.	PUNCT
fnp-3801	504	1	21(10	21(10	NUM
fnp-3801	504	2	):	):	PUNCT
fnp-3801	504	3	p.	p.	NOUN
fnp-3801	504	4	478	478	NUM
fnp-3801	504	5	-	-	SYM
fnp-3801	504	6	85	85	NUM
fnp-3801	504	7	.	.	PUNCT
fnp-3801	505	1	yew	yew	PROPN
fnp-3801	505	2	,	,	PUNCT
fnp-3801	505	3	t.w	t.w	PROPN
fnp-3801	505	4	.	.	PROPN
fnp-3801	505	5	,	,	PUNCT
fnp-3801	505	6	et	et	PROPN
fnp-3801	505	7	al	al	PROPN
fnp-3801	505	8	.	.	PROPN
fnp-3801	505	9	,	,	PUNCT
fnp-3801	505	10	trna	trna	PROPN
fnp-3801	505	11	methyltransferase	methyltransferase	NOUN
fnp-3801	505	12	homologue	homologue	NOUN
fnp-3801	505	13	gene	gene	NOUN
fnp-3801	505	14	trmt10a	trmt10a	NOUN
fnp-3801	505	15	mutation	mutation	NOUN
fnp-3801	505	16	in	in	ADP
fnp-3801	505	17	young	young	ADJ
fnp-3801	505	18	adult	adult	NOUN
fnp-3801	505	19	-	-	PUNCT
fnp-3801	505	20	onset	onset	NOUN
fnp-3801	505	21	diabetes	diabetes	NOUN
fnp-3801	505	22	with	with	ADP
fnp-3801	505	23	intellectual	intellectual	ADJ
fnp-3801	505	24	disability	disability	NOUN
fnp-3801	505	25	,	,	PUNCT
fnp-3801	505	26	microcephaly	microcephaly	NOUN
fnp-3801	505	27	and	and	CCONJ
fnp-3801	505	28	epilepsy	epilepsy	PROPN
fnp-3801	505	29	.	.	PUNCT
fnp-3801	506	1	diabet	diabet	PROPN
fnp-3801	506	2	med	med	PROPN
fnp-3801	506	3	,	,	PUNCT
fnp-3801	506	4	2016	2016	NUM
fnp-3801	506	5	.	.	PUNCT
fnp-3801	507	1	33(9	33(9	X
fnp-3801	507	2	):	):	PUNCT
fnp-3801	507	3	p.	p.	PROPN
fnp-3801	507	4	e21	e21	PROPN
fnp-3801	507	5	-	-	SYM
fnp-3801	507	6	5	5	NUM
fnp-3801	507	7	.	.	X
fnp-3801	507	8	zhang	zhang	PROPN
fnp-3801	507	9	,	,	PUNCT
fnp-3801	507	10	k.	k.	PROPN
fnp-3801	507	11	,	,	PUNCT
fnp-3801	507	12	et	et	PROPN
fnp-3801	507	13	al	al	PROPN
fnp-3801	507	14	.	.	PROPN
fnp-3801	507	15	,	,	PUNCT
fnp-3801	507	16	an	an	DET
fnp-3801	507	17	intellectual	intellectual	ADJ
fnp-3801	507	18	disability	disability	NOUN
fnp-3801	507	19	-	-	PUNCT
fnp-3801	507	20	associated	associate	VERB
fnp-3801	507	21	missense	missense	NOUN
fnp-3801	507	22	variant	variant	NOUN
fnp-3801	507	23	in	in	ADP
fnp-3801	507	24	trmt1	trmt1	PROPN
fnp-3801	507	25	impairs	impair	VERB
fnp-3801	507	26	trna	trna	PROPN
fnp-3801	507	27	modification	modification	NOUN
fnp-3801	507	28	and	and	CCONJ
fnp-3801	507	29	reconstitution	reconstitution	NOUN
fnp-3801	507	30	of	of	ADP
fnp-3801	507	31	enzymatic	enzymatic	ADJ
fnp-3801	507	32	activity	activity	NOUN
fnp-3801	507	33	.	.	PUNCT
fnp-3801	508	1	hum	hum	PROPN
fnp-3801	508	2	mutat	mutat	PROPN
fnp-3801	508	3	,	,	PUNCT
fnp-3801	508	4	2020	2020	NUM
fnp-3801	508	5	.	.	PUNCT
fnp-3801	509	1	41(3	41(3	NUM
fnp-3801	509	2	):	):	PUNCT
fnp-3801	510	1	p.	p.	NOUN
fnp-3801	510	2	600	600	NUM
fnp-3801	510	3	-	-	SYM
fnp-3801	510	4	7	7	NUM
fnp-3801	510	5	.	.	PUNCT
fnp-3801	510	6	abbasi	abbasi	NOUN
fnp-3801	510	7	-	-	PUNCT
fnp-3801	510	8	moheb	moheb	PROPN
fnp-3801	510	9	,	,	PUNCT
fnp-3801	510	10	l.	l.	PROPN
fnp-3801	510	11	,	,	PUNCT
fnp-3801	510	12	et	et	PROPN
fnp-3801	510	13	al	al	PROPN
fnp-3801	510	14	.	.	PROPN
fnp-3801	510	15	,	,	PUNCT
fnp-3801	510	16	mutations	mutation	NOUN
fnp-3801	510	17	in	in	ADP
fnp-3801	510	18	nsun2	nsun2	NOUN
fnp-3801	510	19	cause	cause	VERB
fnp-3801	510	20	autosomal	autosomal	ADJ
fnp-3801	510	21	-	-	PUNCT
fnp-3801	510	22	recessive	recessive	ADJ
fnp-3801	510	23	intellectual	intellectual	ADJ
fnp-3801	510	24	disability	disability	NOUN
fnp-3801	510	25	.	.	PUNCT
fnp-3801	511	1	am	be	AUX
fnp-3801	511	2	j	j	PROPN
fnp-3801	511	3	hum	hum	PROPN
fnp-3801	511	4	genet	genet	PROPN
fnp-3801	511	5	,	,	PUNCT
fnp-3801	511	6	2012	2012	NUM
fnp-3801	511	7	.	.	PUNCT
fnp-3801	512	1	90(5	90(5	NUM
fnp-3801	512	2	):	):	PUNCT
fnp-3801	512	3	p.	p.	NOUN
fnp-3801	512	4	847	847	NUM
fnp-3801	512	5	-	-	SYM
fnp-3801	512	6	55	55	NUM
fnp-3801	512	7	.	.	PUNCT
fnp-3801	513	1	dai	dai	PROPN
fnp-3801	513	2	,	,	PUNCT
fnp-3801	513	3	l.	l.	PROPN
fnp-3801	513	4	,	,	PUNCT
fnp-3801	513	5	et	et	PROPN
fnp-3801	513	6	al	al	PROPN
fnp-3801	513	7	.	.	PROPN
fnp-3801	513	8	,	,	PUNCT
fnp-3801	513	9	positive	positive	ADJ
fnp-3801	513	10	association	association	NOUN
fnp-3801	513	11	of	of	ADP
fnp-3801	513	12	the	the	DET
fnp-3801	513	13	ftsj1	ftsj1	PROPN
fnp-3801	513	14	gene	gene	NOUN
fnp-3801	513	15	polymorphisms	polymorphism	NOUN
fnp-3801	513	16	with	with	ADP
fnp-3801	513	17	nonsyndromic	nonsyndromic	ADJ
fnp-3801	513	18	x	x	VERB
fnp-3801	513	19	-	-	VERB
fnp-3801	513	20	linked	link	VERB
fnp-3801	513	21	mental	mental	ADJ
fnp-3801	513	22	retardation	retardation	NOUN
fnp-3801	513	23	in	in	ADP
fnp-3801	513	24	young	young	ADJ
fnp-3801	513	25	chinese	chinese	ADJ
fnp-3801	513	26	male	male	ADJ
fnp-3801	513	27	subjects	subject	NOUN
fnp-3801	513	28	.	.	PUNCT
fnp-3801	514	1	j	j	PROPN
fnp-3801	514	2	hum	hum	PROPN
fnp-3801	514	3	genet	genet	PROPN
fnp-3801	514	4	,	,	PUNCT
fnp-3801	514	5	2008	2008	NUM
fnp-3801	514	6	.	.	PUNCT
fnp-3801	515	1	53(7	53(7	NUM
fnp-3801	515	2	):	):	PUNCT
fnp-3801	515	3	p.	p.	NOUN
fnp-3801	515	4	592	592	NUM
fnp-3801	515	5	-	-	SYM
fnp-3801	515	6	7	7	NUM
fnp-3801	515	7	.	.	PUNCT
fnp-3801	516	1	nagayoshi	nagayoshi	PROPN
fnp-3801	516	2	,	,	PUNCT
fnp-3801	516	3	y.	y.	PROPN
fnp-3801	516	4	,	,	PUNCT
fnp-3801	516	5	et	et	PROPN
fnp-3801	516	6	al	al	PROPN
fnp-3801	516	7	.	.	PROPN
fnp-3801	516	8	,	,	PUNCT
fnp-3801	516	9	loss	loss	NOUN
fnp-3801	516	10	of	of	ADP
fnp-3801	516	11	ftsj1	ftsj1	PROPN
fnp-3801	516	12	perturbs	perturb	VERB
fnp-3801	516	13	codon	codon	NOUN
fnp-3801	516	14	-	-	PUNCT
fnp-3801	516	15	specific	specific	ADJ
fnp-3801	516	16	translation	translation	NOUN
fnp-3801	516	17	efficiency	efficiency	NOUN
fnp-3801	516	18	in	in	ADP
fnp-3801	516	19	the	the	DET
fnp-3801	516	20	brain	brain	NOUN
fnp-3801	516	21	and	and	CCONJ
fnp-3801	516	22	is	be	AUX
fnp-3801	516	23	associated	associate	VERB
fnp-3801	516	24	with	with	ADP
fnp-3801	516	25	x	x	ADJ
fnp-3801	516	26	-	-	ADJ
fnp-3801	516	27	linked	link	VERB
fnp-3801	516	28	intellectual	intellectual	ADJ
fnp-3801	516	29	disability	disability	NOUN
fnp-3801	516	30	.	.	PUNCT
fnp-3801	517	1	sci	sci	PROPN
fnp-3801	517	2	adv	adv	PROPN
fnp-3801	517	3	,	,	PUNCT
fnp-3801	517	4	2021	2021	NUM
fnp-3801	517	5	.	.	PUNCT
fnp-3801	518	1	7(13	7(13	NUM
fnp-3801	518	2	):	):	PUNCT
fnp-3801	518	3	p.	p.	PROPN
fnp-3801	518	4	eabf3072	eabf3072	PROPN
fnp-3801	518	5	.	.	PUNCT
fnp-3801	519	1	brafman	brafman	PROPN
fnp-3801	519	2	,	,	PUNCT
fnp-3801	519	3	d.	d.	PROPN
fnp-3801	519	4	and	and	CCONJ
fnp-3801	519	5	willert	willert	PROPN
fnp-3801	519	6	,	,	PUNCT
fnp-3801	519	7	k.	k.	PROPN
fnp-3801	519	8	,	,	PUNCT
fnp-3801	519	9	wnt	wnt	PROPN
fnp-3801	519	10	/	/	SYM
fnp-3801	519	11	beta	beta	NOUN
fnp-3801	519	12	-	-	PUNCT
fnp-3801	519	13	catenin	catenin	NOUN
fnp-3801	519	14	signaling	signal	VERB
fnp-3801	519	15	during	during	ADP
fnp-3801	519	16	early	early	ADJ
fnp-3801	519	17	vertebrate	vertebrate	ADJ
fnp-3801	519	18	neural	neural	ADJ
fnp-3801	519	19	development	development	NOUN
fnp-3801	519	20	.	.	PUNCT
fnp-3801	520	1	dev	dev	PROPN
fnp-3801	520	2	neurobiol	neurobiol	PROPN
fnp-3801	520	3	,	,	PUNCT
fnp-3801	520	4	2017	2017	NUM
fnp-3801	520	5	.	.	PUNCT
fnp-3801	521	1	77(11	77(11	NUM
fnp-3801	521	2	):	):	PUNCT
fnp-3801	521	3	p.	p.	NOUN
fnp-3801	521	4	1239	1239	NUM
fnp-3801	521	5	-	-	SYM
fnp-3801	521	6	59	59	NUM
fnp-3801	521	7	.	.	PUNCT
fnp-3801	522	1	stahl	stahl	PROPN
fnp-3801	522	2	,	,	PUNCT
fnp-3801	522	3	a.l	a.l	PROPN
fnp-3801	522	4	.	.	PROPN
fnp-3801	522	5	,	,	PUNCT
fnp-3801	522	6	et	et	PROPN
fnp-3801	522	7	al	al	PROPN
fnp-3801	522	8	.	.	PROPN
fnp-3801	522	9	,	,	PUNCT
fnp-3801	522	10	exosomes	exosome	NOUN
fnp-3801	522	11	and	and	CCONJ
fnp-3801	522	12	microvesicles	microvesicle	NOUN
fnp-3801	522	13	in	in	ADP
fnp-3801	522	14	normal	normal	ADJ
fnp-3801	522	15	physiology	physiology	NOUN
fnp-3801	522	16	,	,	PUNCT
fnp-3801	522	17	pathophysiology	pathophysiology	NOUN
fnp-3801	522	18	,	,	PUNCT
fnp-3801	522	19	and	and	CCONJ
fnp-3801	522	20	renal	renal	ADJ
fnp-3801	522	21	diseases	disease	NOUN
fnp-3801	522	22	.	.	PUNCT
fnp-3801	523	1	pediatr	pediatr	ADJ
fnp-3801	523	2	nephrol	nephrol	NOUN
fnp-3801	523	3	,	,	PUNCT
fnp-3801	523	4	2019	2019	NUM
fnp-3801	523	5	.	.	PUNCT
fnp-3801	524	1	34(1	34(1	NUM
fnp-3801	524	2	):	):	PUNCT
fnp-3801	525	1	p.	p.	NOUN
fnp-3801	525	2	11	11	NUM
fnp-3801	525	3	-	-	SYM
fnp-3801	525	4	30	30	NUM
fnp-3801	525	5	.	.	PUNCT
fnp-3801	526	1	ha	ha	INTJ
fnp-3801	526	2	,	,	PUNCT
fnp-3801	526	3	b.g	b.g	PROPN
fnp-3801	526	4	.	.	PROPN
fnp-3801	526	5	,	,	PUNCT
fnp-3801	526	6	et	et	PROPN
fnp-3801	526	7	al	al	PROPN
fnp-3801	526	8	.	.	PROPN
fnp-3801	526	9	,	,	PUNCT
fnp-3801	526	10	depletion	depletion	NOUN
fnp-3801	526	11	of	of	ADP
fnp-3801	526	12	mitochondrial	mitochondrial	ADJ
fnp-3801	526	13	components	component	NOUN
fnp-3801	526	14	from	from	ADP
fnp-3801	526	15	extracellular	extracellular	ADJ
fnp-3801	526	16	vesicles	vesicle	NOUN
fnp-3801	526	17	secreted	secrete	VERB
fnp-3801	526	18	from	from	ADP
fnp-3801	526	19	astrocytes	astrocyte	NOUN
fnp-3801	526	20	in	in	ADP
fnp-3801	526	21	a	a	DET
fnp-3801	526	22	mouse	mouse	NOUN
fnp-3801	526	23	model	model	NOUN
fnp-3801	526	24	of	of	ADP
fnp-3801	526	25	fragile	fragile	ADJ
fnp-3801	526	26	x	x	NOUN
fnp-3801	526	27	syndrome	syndrome	NOUN
fnp-3801	526	28	.	.	PUNCT
fnp-3801	527	1	int	int	PROPN
fnp-3801	527	2	j	j	PROPN
fnp-3801	527	3	mol	mol	ADP
fnp-3801	527	4	sci	sci	PROPN
fnp-3801	527	5	,	,	PUNCT
fnp-3801	527	6	2021	2021	NUM
fnp-3801	527	7	.	.	PUNCT
fnp-3801	528	1	22(1	22(1	NUM
fnp-3801	528	2	):	):	PUNCT
fnp-3801	528	3	p.	p.	NOUN
fnp-3801	528	4	410	410	NUM
fnp-3801	528	5	.	.	PUNCT
fnp-3801	529	1	zhang	zhang	PROPN
fnp-3801	529	2	,	,	PUNCT
fnp-3801	529	3	b.	b.	PROPN
fnp-3801	529	4	,	,	PUNCT
fnp-3801	529	5	et	et	PROPN
fnp-3801	529	6	al	al	PROPN
fnp-3801	529	7	.	.	PROPN
fnp-3801	529	8	,	,	PUNCT
fnp-3801	529	9	stimulated	stimulate	VERB
fnp-3801	529	10	human	human	ADJ
fnp-3801	529	11	mast	mast	NOUN
fnp-3801	529	12	cells	cell	NOUN
fnp-3801	529	13	secrete	secrete	VERB
fnp-3801	529	14	mitochondrial	mitochondrial	ADJ
fnp-3801	529	15	components	component	NOUN
fnp-3801	529	16	that	that	PRON
fnp-3801	529	17	have	have	AUX
fnp-3801	529	18	autocrine	autocrine	NOUN
fnp-3801	529	19	and	and	CCONJ
fnp-3801	529	20	paracrine	paracrine	VERB
fnp-3801	529	21	inflammatory	inflammatory	ADJ
fnp-3801	529	22	actions	action	NOUN
fnp-3801	529	23	.	.	PUNCT
fnp-3801	530	1	plos	plos	PROPN
fnp-3801	530	2	one	one	NUM
fnp-3801	530	3	,	,	PUNCT
fnp-3801	530	4	2012	2012	NUM
fnp-3801	530	5	.	.	PUNCT
fnp-3801	531	1	7(12	7(12	NUM
fnp-3801	531	2	):	):	PUNCT
fnp-3801	531	3	p.	p.	NOUN
fnp-3801	531	4	e49767	e49767	PROPN
fnp-3801	531	5	.	.	PUNCT
fnp-3801	532	1	guescini	guescini	NOUN
fnp-3801	532	2	,	,	PUNCT
fnp-3801	532	3	m.	m.	NOUN
fnp-3801	532	4	,	,	PUNCT
fnp-3801	532	5	et	et	PROPN
fnp-3801	532	6	al	al	PROPN
fnp-3801	532	7	.	.	PROPN
fnp-3801	532	8	,	,	PUNCT
fnp-3801	532	9	astrocytes	astrocyte	NOUN
fnp-3801	532	10	and	and	CCONJ
fnp-3801	532	11	glioblastoma	glioblastoma	NOUN
fnp-3801	532	12	cells	cell	NOUN
fnp-3801	532	13	release	release	VERB
fnp-3801	532	14	exosomes	exosome	NOUN
fnp-3801	532	15	carrying	carry	VERB
fnp-3801	532	16	mtdna	mtdna	ADV
fnp-3801	532	17	.	.	PUNCT
fnp-3801	533	1	j	j	PROPN
fnp-3801	533	2	neural	neural	ADJ
fnp-3801	533	3	transm	transm	PROPN
fnp-3801	533	4	(	(	PUNCT
fnp-3801	533	5	vienna	vienna	PROPN
fnp-3801	533	6	)	)	PUNCT
fnp-3801	533	7	,	,	PUNCT
fnp-3801	533	8	2010	2010	NUM
fnp-3801	533	9	.	.	PUNCT
fnp-3801	534	1	117(1	117(1	NUM
fnp-3801	534	2	):	):	PUNCT
fnp-3801	534	3	p.	p.	NOUN
fnp-3801	534	4	1	1	NUM
fnp-3801	534	5	-	-	SYM
fnp-3801	534	6	4	4	NUM
fnp-3801	534	7	.	.	PUNCT
fnp-3801	535	1	phinney	phinney	PROPN
fnp-3801	535	2	,	,	PUNCT
fnp-3801	535	3	d.g	d.g	PROPN
fnp-3801	535	4	.	.	PROPN
fnp-3801	535	5	,	,	PUNCT
fnp-3801	535	6	et	et	PROPN
fnp-3801	535	7	al	al	PROPN
fnp-3801	535	8	.	.	PROPN
fnp-3801	535	9	,	,	PUNCT
fnp-3801	535	10	mesenchymal	mesenchymal	NOUN
fnp-3801	535	11	stem	stem	NOUN
fnp-3801	535	12	cells	cell	NOUN
fnp-3801	535	13	use	use	VERB
fnp-3801	535	14	extracellular	extracellular	ADJ
fnp-3801	535	15	vesicles	vesicle	NOUN
fnp-3801	535	16	to	to	PART
fnp-3801	535	17	outsource	outsource	VERB
fnp-3801	535	18	mitophagy	mitophagy	NOUN
fnp-3801	535	19	and	and	CCONJ
fnp-3801	535	20	shuttle	shuttle	NOUN
fnp-3801	535	21	micrornas	microrna	NOUN
fnp-3801	535	22	.	.	PUNCT
fnp-3801	536	1	nat	nat	PROPN
fnp-3801	536	2	commun	commun	PROPN
fnp-3801	536	3	,	,	PUNCT
fnp-3801	536	4	2015	2015	NUM
fnp-3801	536	5	.	.	PUNCT
fnp-3801	537	1	6	6	NUM
fnp-3801	537	2	:	:	PUNCT
fnp-3801	537	3	p.	p.	NOUN
fnp-3801	537	4	8472	8472	NUM
fnp-3801	537	5	.	.	PUNCT
fnp-3801	538	1	hayakawa	hayakawa	PROPN
fnp-3801	538	2	,	,	PUNCT
fnp-3801	538	3	k.	k.	PROPN
fnp-3801	538	4	,	,	PUNCT
fnp-3801	538	5	et	et	PROPN
fnp-3801	538	6	al	al	PROPN
fnp-3801	538	7	.	.	PROPN
fnp-3801	538	8	,	,	PUNCT
fnp-3801	538	9	transfer	transfer	NOUN
fnp-3801	538	10	of	of	ADP
fnp-3801	538	11	mitochondria	mitochondria	NOUN
fnp-3801	538	12	from	from	ADP
fnp-3801	538	13	astrocytes	astrocyte	NOUN
fnp-3801	538	14	to	to	ADP
fnp-3801	538	15	neurons	neuron	NOUN
fnp-3801	538	16	after	after	ADP
fnp-3801	538	17	stroke	stroke	NOUN
fnp-3801	538	18	.	.	PUNCT
fnp-3801	539	1	nature	nature	NOUN
fnp-3801	539	2	,	,	PUNCT
fnp-3801	539	3	2016	2016	NUM
fnp-3801	539	4	.	.	PUNCT
fnp-3801	540	1	535(7613	535(7613	NUM
fnp-3801	540	2	):	):	PUNCT
fnp-3801	540	3	p.	p.	NOUN
fnp-3801	540	4	551	551	NUM
fnp-3801	540	5	-	-	SYM
fnp-3801	540	6	5	5	NUM
fnp-3801	540	7	.	.	PUNCT
fnp-3801	541	1	jeppesen	jeppesen	PROPN
fnp-3801	541	2	,	,	PUNCT
fnp-3801	541	3	d.k	d.k	PROPN
fnp-3801	541	4	.	.	PROPN
fnp-3801	541	5	,	,	PUNCT
fnp-3801	541	6	et	et	PROPN
fnp-3801	541	7	al	al	PROPN
fnp-3801	541	8	.	.	PROPN
fnp-3801	541	9	,	,	PUNCT
fnp-3801	541	10	reassessment	reassessment	NOUN
fnp-3801	541	11	of	of	ADP
fnp-3801	541	12	exosome	exosome	PROPN
fnp-3801	541	13	composition	composition	NOUN
fnp-3801	541	14	.	.	PUNCT
fnp-3801	542	1	cell	cell	NOUN
fnp-3801	542	2	,	,	PUNCT
fnp-3801	542	3	2019	2019	NUM
fnp-3801	542	4	.	.	PUNCT
fnp-3801	543	1	177(2	177(2	NUM
fnp-3801	543	2	):	):	PUNCT
fnp-3801	543	3	p.	p.	NOUN
fnp-3801	543	4	428	428	NUM
fnp-3801	543	5	-	-	SYM
fnp-3801	543	6	45	45	NUM
fnp-3801	543	7	e18	e18	PROPN
fnp-3801	543	8	.	.	PROPN
fnp-3801	543	9	d'acunzo	d'acunzo	PROPN
fnp-3801	543	10	,	,	PUNCT
fnp-3801	543	11	p.	p.	PROPN
fnp-3801	543	12	,	,	PUNCT
fnp-3801	543	13	et	et	PROPN
fnp-3801	543	14	al	al	PROPN
fnp-3801	543	15	.	.	PROPN
fnp-3801	543	16	,	,	PUNCT
fnp-3801	543	17	mitovesicles	mitovesicle	NOUN
fnp-3801	543	18	are	be	AUX
fnp-3801	543	19	a	a	DET
fnp-3801	543	20	novel	novel	ADJ
fnp-3801	543	21	population	population	NOUN
fnp-3801	543	22	of	of	ADP
fnp-3801	543	23	extracellular	extracellular	ADJ
fnp-3801	543	24	vesicles	vesicle	NOUN
fnp-3801	543	25	of	of	ADP
fnp-3801	543	26	mitochondrial	mitochondrial	ADJ
fnp-3801	543	27	origin	origin	NOUN
fnp-3801	543	28	altered	alter	VERB
fnp-3801	543	29	in	in	ADP
fnp-3801	543	30	down	down	ADP
fnp-3801	543	31	syndrome	syndrome	NOUN
fnp-3801	543	32	.	.	PUNCT
fnp-3801	544	1	sci	sci	PROPN
fnp-3801	544	2	adv	adv	PROPN
fnp-3801	544	3	,	,	PUNCT
fnp-3801	544	4	2021	2021	NUM
fnp-3801	544	5	.	.	PUNCT
fnp-3801	545	1	7(7	7(7	NUM
fnp-3801	545	2	):	):	PUNCT
fnp-3801	546	1	p.	p.	PROPN
fnp-3801	546	2	eabe5085	eabe5085	PROPN
fnp-3801	546	3	.	.	PUNCT
fnp-3801	547	1	izzo	izzo	PROPN
fnp-3801	547	2	,	,	PUNCT
fnp-3801	547	3	a.	a.	PROPN
fnp-3801	547	4	,	,	PUNCT
fnp-3801	547	5	et	et	PROPN
fnp-3801	547	6	al	al	PROPN
fnp-3801	547	7	.	.	PROPN
fnp-3801	547	8	,	,	PUNCT
fnp-3801	547	9	mitochondrial	mitochondrial	ADJ
fnp-3801	547	10	dysfunction	dysfunction	NOUN
fnp-3801	547	11	in	in	ADP
fnp-3801	547	12	down	down	ADP
fnp-3801	547	13	syndrome	syndrome	NOUN
fnp-3801	547	14	:	:	PUNCT
fnp-3801	547	15	molecular	molecular	ADJ
fnp-3801	547	16	mechanisms	mechanism	NOUN
fnp-3801	547	17	and	and	CCONJ
fnp-3801	547	18	therapeutic	therapeutic	ADJ
fnp-3801	547	19	targets	target	NOUN
fnp-3801	547	20	.	.	PUNCT
fnp-3801	548	1	mol	mol	ADP
fnp-3801	548	2	med	med	ADJ
fnp-3801	548	3	,	,	PUNCT
fnp-3801	548	4	2018	2018	NUM
fnp-3801	548	5	.	.	PUNCT
fnp-3801	549	1	24(1	24(1	NUM
fnp-3801	549	2	):	):	PUNCT
fnp-3801	549	3	p.	p.	NOUN
fnp-3801	549	4	2	2	NUM
fnp-3801	549	5	.	.	X
fnp-3801	550	1	pinto	pinto	NOUN
fnp-3801	550	2	,	,	PUNCT
fnp-3801	550	3	b.	b.	PROPN
fnp-3801	550	4	,	,	PUNCT
fnp-3801	550	5	et	et	PROPN
fnp-3801	550	6	al	al	PROPN
fnp-3801	550	7	.	.	PROPN
fnp-3801	550	8	,	,	PUNCT
fnp-3801	550	9	rescuing	rescue	VERB
fnp-3801	550	10	over	over	ADV
fnp-3801	550	11	-	-	PUNCT
fnp-3801	550	12	activated	activate	VERB
fnp-3801	550	13	microglia	microglia	NOUN
fnp-3801	550	14	restores	restore	VERB
fnp-3801	550	15	cognitive	cognitive	ADJ
fnp-3801	550	16	performance	performance	NOUN
fnp-3801	550	17	in	in	ADP
fnp-3801	550	18	juvenile	juvenile	ADJ
fnp-3801	550	19	animals	animal	NOUN
fnp-3801	550	20	of	of	ADP
fnp-3801	550	21	the	the	DET
fnp-3801	550	22	dp(16	dp(16	PROPN
fnp-3801	550	23	)	)	PUNCT
fnp-3801	550	24	mouse	mouse	NOUN
fnp-3801	550	25	model	model	NOUN
fnp-3801	550	26	of	of	ADP
fnp-3801	550	27	down	down	ADP
fnp-3801	550	28	syndrome	syndrome	NOUN
fnp-3801	550	29	.	.	PUNCT
fnp-3801	551	1	neuron	neuron	PROPN
fnp-3801	551	2	,	,	PUNCT
fnp-3801	551	3	2020	2020	NUM
fnp-3801	551	4	.	.	PUNCT
fnp-3801	552	1	108(5	108(5	NUM
fnp-3801	552	2	):	):	PUNCT
fnp-3801	552	3	p.	p.	NOUN
fnp-3801	552	4	887	887	NUM
fnp-3801	552	5	-	-	SYM
fnp-3801	552	6	904	904	NUM
fnp-3801	552	7	e12	e12	NOUN
fnp-3801	552	8	.	.	PUNCT
fnp-3801	553	1	copyright	copyright	NOUN
fnp-3801	553	2	:	:	PUNCT
fnp-3801	553	3	©	©	PROPN
fnp-3801	553	4	2022	2022	NUM
fnp-3801	553	5	the	the	DET
fnp-3801	553	6	author(s	author(s	NOUN
fnp-3801	553	7	)	)	PUNCT
fnp-3801	553	8	.	.	PUNCT
fnp-3801	554	1	this	this	PRON
fnp-3801	554	2	is	be	AUX
fnp-3801	554	3	an	an	DET
fnp-3801	554	4	open	open	ADJ
fnp-3801	554	5	access	access	NOUN
fnp-3801	554	6	article	article	NOUN
fnp-3801	554	7	distributed	distribute	VERB
fnp-3801	554	8	under	under	ADP
fnp-3801	554	9	the	the	DET
fnp-3801	554	10	terms	term	NOUN
fnp-3801	554	11	of	of	ADP
fnp-3801	554	12	the	the	DET
fnp-3801	554	13	creative	creative	ADJ
fnp-3801	554	14	commons	common	NOUN
fnp-3801	554	15	attribution	attribution	NOUN
fnp-3801	554	16	4.0	4.0	NUM
fnp-3801	554	17	international	international	ADJ
fnp-3801	554	18	license	license	NOUN
fnp-3801	554	19	(	(	PUNCT
fnp-3801	554	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-3801	554	21	)	)	PUNCT
fnp-3801	554	22	,	,	PUNCT
fnp-3801	554	23	which	which	PRON
fnp-3801	554	24	permits	permit	VERB
fnp-3801	554	25	unrestricted	unrestricted	ADJ
fnp-3801	554	26	use	use	NOUN
fnp-3801	554	27	,	,	PUNCT
fnp-3801	554	28	distribution	distribution	NOUN
fnp-3801	554	29	,	,	PUNCT
fnp-3801	554	30	and	and	CCONJ
fnp-3801	554	31	reproduction	reproduction	NOUN
fnp-3801	554	32	in	in	ADP
fnp-3801	554	33	any	any	DET
fnp-3801	554	34	medium	medium	NOUN
fnp-3801	554	35	,	,	PUNCT
fnp-3801	554	36	provided	provide	VERB
fnp-3801	554	37	the	the	DET
fnp-3801	554	38	original	original	ADJ
fnp-3801	554	39	author	author	NOUN
fnp-3801	554	40	and	and	CCONJ
fnp-3801	554	41	source	source	NOUN
fnp-3801	554	42	are	be	AUX
fnp-3801	554	43	credited	credit	VERB
fnp-3801	554	44	,	,	PUNCT
fnp-3801	554	45	a	a	DET
fnp-3801	554	46	link	link	NOUN
fnp-3801	554	47	to	to	ADP
fnp-3801	554	48	the	the	DET
fnp-3801	554	49	creative	creative	ADJ
fnp-3801	554	50	commons	common	NOUN
fnp-3801	554	51	license	license	NOUN
fnp-3801	554	52	is	be	AUX
fnp-3801	554	53	provided	provide	VERB
fnp-3801	554	54	,	,	PUNCT
fnp-3801	554	55	and	and	CCONJ
fnp-3801	554	56	any	any	DET
fnp-3801	554	57	changes	change	NOUN
fnp-3801	554	58	are	be	AUX
fnp-3801	554	59	indicated	indicate	VERB
fnp-3801	554	60	.	.	PUNCT
fnp-3801	555	1	the	the	DET
fnp-3801	555	2	creative	creative	ADJ
fnp-3801	555	3	commons	common	NOUN
fnp-3801	555	4	public	public	ADJ
fnp-3801	555	5	domain	domain	NOUN
fnp-3801	555	6	dedication	dedication	NOUN
fnp-3801	555	7	waiver	waiver	NOUN
fnp-3801	555	8	(	(	PUNCT
fnp-3801	555	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-3801	555	10	)	)	PUNCT
fnp-3801	555	11	applies	apply	VERB
fnp-3801	555	12	to	to	ADP
fnp-3801	555	13	the	the	DET
fnp-3801	555	14	data	datum	NOUN
fnp-3801	555	15	made	make	VERB
fnp-3801	555	16	available	available	ADJ
fnp-3801	555	17	in	in	ADP
fnp-3801	555	18	this	this	DET
fnp-3801	555	19	article	article	NOUN
fnp-3801	555	20	,	,	PUNCT
fnp-3801	555	21	unless	unless	SCONJ
fnp-3801	555	22	otherwise	otherwise	ADV
fnp-3801	555	23	stated	state	VERB
fnp-3801	555	24	.	.	PUNCT