id	sid	tid	token	lemma	pos
fnp-3806	1	1	alzheimer	alzheimer	PROPN
fnp-3806	1	2	’s	’s	PART
fnp-3806	1	3	disease	disease	NOUN
fnp-3806	1	4	is	be	AUX
fnp-3806	1	5	an	an	DET
fnp-3806	1	6	inherent	inherent	ADJ
fnp-3806	1	7	,	,	PUNCT
fnp-3806	1	8	natural	natural	ADJ
fnp-3806	1	9	part	part	NOUN
fnp-3806	1	10	of	of	ADP
fnp-3806	1	11	human	human	ADJ
fnp-3806	1	12	brain	brain	NOUN
fnp-3806	1	13	aging	aging	NOUN
fnp-3806	1	14	:	:	PUNCT
fnp-3806	1	15	an	an	DET
fnp-3806	1	16	integrated	integrated	ADJ
fnp-3806	1	17	perspective	perspective	NOUN
fnp-3806	1	18	feel	feel	VERB
fnp-3806	1	19	free	free	ADJ
fnp-3806	1	20	to	to	PART
fnp-3806	1	21	add	add	VERB
fnp-3806	1	22	comments	comment	NOUN
fnp-3806	1	23	by	by	ADP
fnp-3806	1	24	clicking	click	VERB
fnp-3806	1	25	these	these	DET
fnp-3806	1	26	icons	icon	NOUN
fnp-3806	1	27	on	on	ADP
fnp-3806	1	28	the	the	DET
fnp-3806	1	29	sidebar	sidebar	NOUN
fnp-3806	1	30	free	free	ADJ
fnp-3806	1	31	neuropathology	neuropathology	NOUN
fnp-3806	1	32	3:17	3:17	NUM
fnp-3806	1	33	(	(	PUNCT
fnp-3806	1	34	2022	2022	NUM
fnp-3806	1	35	)	)	PUNCT
fnp-3806	1	36	review	review	VERB
fnp-3806	1	37	alzheimer	alzheimer	PROPN
fnp-3806	1	38	’s	’s	PART
fnp-3806	1	39	disease	disease	NOUN
fnp-3806	1	40	is	be	AUX
fnp-3806	1	41	an	an	DET
fnp-3806	1	42	inherent	inherent	ADJ
fnp-3806	1	43	,	,	PUNCT
fnp-3806	1	44	natural	natural	ADJ
fnp-3806	1	45	part	part	NOUN
fnp-3806	1	46	of	of	ADP
fnp-3806	1	47	human	human	ADJ
fnp-3806	1	48	brain	brain	NOUN
fnp-3806	1	49	aging	aging	NOUN
fnp-3806	1	50	:	:	PUNCT
fnp-3806	1	51	an	an	DET
fnp-3806	1	52	integrated	integrated	ADJ
fnp-3806	1	53	perspective	perspective	NOUN
fnp-3806	1	54	isidro	isidro	PROPN
fnp-3806	1	55	ferrer	ferrer	PROPN
fnp-3806	1	56	department	department	PROPN
fnp-3806	1	57	of	of	ADP
fnp-3806	1	58	pathology	pathology	PROPN
fnp-3806	1	59	and	and	CCONJ
fnp-3806	1	60	experimental	experimental	ADJ
fnp-3806	1	61	therapeutics	therapeutic	NOUN
fnp-3806	1	62	,	,	PUNCT
fnp-3806	1	63	university	university	PROPN
fnp-3806	1	64	of	of	ADP
fnp-3806	1	65	barcelona	barcelona	PROPN
fnp-3806	1	66	;	;	PUNCT
fnp-3806	1	67	emeritus	emeritus	ADJ
fnp-3806	1	68	researcher	researcher	NOUN
fnp-3806	1	69	of	of	ADP
fnp-3806	1	70	the	the	DET
fnp-3806	1	71	bellvitge	bellvitge	VERB
fnp-3806	1	72	institute	institute	NOUN
fnp-3806	1	73	of	of	ADP
fnp-3806	1	74	biomedical	biomedical	ADJ
fnp-3806	1	75	research	research	NOUN
fnp-3806	1	76	(	(	PUNCT
fnp-3806	1	77	idibell	idibell	PROPN
fnp-3806	1	78	)	)	PUNCT
fnp-3806	1	79	;	;	PUNCT
fnp-3806	1	80	biomedical	biomedical	ADJ
fnp-3806	1	81	research	research	NOUN
fnp-3806	1	82	network	network	NOUN
fnp-3806	1	83	of	of	ADP
fnp-3806	1	84	neurodegenerative	neurodegenerative	ADJ
fnp-3806	1	85	diseases	disease	NOUN
fnp-3806	1	86	(	(	PUNCT
fnp-3806	1	87	ciberned	ciberne	VERB
fnp-3806	1	88	)	)	PUNCT
fnp-3806	1	89	;	;	PUNCT
fnp-3806	1	90	institute	institute	NOUN
fnp-3806	1	91	of	of	ADP
fnp-3806	1	92	neurosciences	neuroscience	NOUN
fnp-3806	1	93	,	,	PUNCT
fnp-3806	1	94	university	university	PROPN
fnp-3806	1	95	of	of	ADP
fnp-3806	1	96	barcelona	barcelona	PROPN
fnp-3806	1	97	;	;	PUNCT
fnp-3806	1	98	hospitalet	hospitalet	PROPN
fnp-3806	1	99	de	de	PROPN
fnp-3806	1	100	llobregat	llobregat	PROPN
fnp-3806	1	101	,	,	PUNCT
fnp-3806	1	102	barcelona	barcelona	PROPN
fnp-3806	1	103	,	,	PUNCT
fnp-3806	1	104	spain	spain	PROPN
fnp-3806	1	105	corresponding	corresponding	PROPN
fnp-3806	1	106	author	author	NOUN
fnp-3806	1	107	:	:	PUNCT
fnp-3806	1	108	i.	i.	PROPN
fnp-3806	1	109	ferrer	ferrer	PROPN
fnp-3806	1	110	·	·	PUNCT
fnp-3806	1	111	department	department	PROPN
fnp-3806	1	112	of	of	ADP
fnp-3806	1	113	pathology	pathology	NOUN
fnp-3806	1	114	and	and	CCONJ
fnp-3806	1	115	experimental	experimental	ADJ
fnp-3806	1	116	therapeutics	therapeutic	NOUN
fnp-3806	1	117	·	·	PUNCT
fnp-3806	1	118	university	university	NOUN
fnp-3806	1	119	of	of	ADP
fnp-3806	1	120	barcelona	barcelona	PROPN
fnp-3806	1	121	·	·	PUNCT
fnp-3806	1	122	campus	campus	NOUN
fnp-3806	1	123	bellvitge	bellvitge	VERB
fnp-3806	1	124	·	·	PUNCT
fnp-3806	1	125	carrer	carrer	NOUN
fnp-3806	1	126	feixa	feixa	NOUN
fnp-3806	1	127	llarga	llarga	ADV
fnp-3806	1	128	sn	sn	PROPN
fnp-3806	1	129	·	·	PUNCT
fnp-3806	1	130	08907	08907	NUM
fnp-3806	1	131	hospitalet	hospitalet	PROPN
fnp-3806	1	132	de	de	PROPN
fnp-3806	1	133	llobregat	llobregat	PROPN
fnp-3806	1	134	·	·	PUNCT
fnp-3806	1	135	spain	spain	PROPN
fnp-3806	1	136	8082ifa@gmail.com	8082ifa@gmail.com	NUM
fnp-3806	1	137	submitted	submit	VERB
fnp-3806	1	138	:	:	PUNCT
fnp-3806	1	139	25	25	NUM
fnp-3806	1	140	february	february	NOUN
fnp-3806	1	141	2022	2022	NUM
fnp-3806	1	142	accepted	accept	VERB
fnp-3806	1	143	:	:	PUNCT
fnp-3806	1	144	21	21	NUM
fnp-3806	1	145	june	june	PROPN
fnp-3806	1	146	2022	2022	NUM
fnp-3806	1	147	copyedited	copyedit	VERB
fnp-3806	1	148	by	by	ADP
fnp-3806	1	149	:	:	PUNCT
fnp-3806	1	150	félicia	félicia	PROPN
fnp-3806	1	151	jeannelle	jeannelle	NOUN
fnp-3806	1	152	published	publish	VERB
fnp-3806	1	153	:	:	PUNCT
fnp-3806	1	154	08	08	NUM
fnp-3806	1	155	july	july	PROPN
fnp-3806	1	156	2022	2022	NUM
fnp-3806	1	157	https://doi.org/10.17879/freeneuropathology-2022-3806	https://doi.org/10.17879/freeneuropathology-2022-3806	ADP
fnp-3806	1	158	keywords	keyword	NOUN
fnp-3806	1	159	:	:	PUNCT
fnp-3806	1	160	alzheimer	alzheimer	PROPN
fnp-3806	1	161	’s	’s	PART
fnp-3806	1	162	disease	disease	NOUN
fnp-3806	1	163	,	,	PUNCT
fnp-3806	1	164	human	human	ADJ
fnp-3806	1	165	brain	brain	NOUN
fnp-3806	1	166	aging	aging	NOUN
fnp-3806	1	167	,	,	PUNCT
fnp-3806	1	168	genetics	genetic	NOUN
fnp-3806	1	169	,	,	PUNCT
fnp-3806	1	170	epigenetics	epigenetic	NOUN
fnp-3806	1	171	,	,	PUNCT
fnp-3806	1	172	new	new	ADJ
fnp-3806	1	173	therapies	therapy	NOUN
fnp-3806	1	174	abstract	abstract	ADJ
fnp-3806	1	175	alzheimer	alzheimer	PROPN
fnp-3806	1	176	disease	disease	NOUN
fnp-3806	1	177	is	be	AUX
fnp-3806	1	178	one	one	NUM
fnp-3806	1	179	of	of	ADP
fnp-3806	1	180	the	the	DET
fnp-3806	1	181	most	most	ADV
fnp-3806	1	182	challenging	challenging	ADJ
fnp-3806	1	183	demons	demon	NOUN
fnp-3806	1	184	in	in	ADP
fnp-3806	1	185	our	our	PRON
fnp-3806	1	186	society	society	NOUN
fnp-3806	1	187	due	due	ADP
fnp-3806	1	188	to	to	ADP
fnp-3806	1	189	its	its	PRON
fnp-3806	1	190	very	very	ADV
fnp-3806	1	191	high	high	ADJ
fnp-3806	1	192	prevalence	prevalence	NOUN
fnp-3806	1	193	and	and	CCONJ
fnp-3806	1	194	its	its	PRON
fnp-3806	1	195	clinical	clinical	ADJ
fnp-3806	1	196	manifestations	manifestation	NOUN
fnp-3806	1	197	which	which	PRON
fnp-3806	1	198	cause	cause	VERB
fnp-3806	1	199	deterioration	deterioration	NOUN
fnp-3806	1	200	of	of	ADP
fnp-3806	1	201	cognition	cognition	NOUN
fnp-3806	1	202	,	,	PUNCT
fnp-3806	1	203	intelligence	intelligence	NOUN
fnp-3806	1	204	,	,	PUNCT
fnp-3806	1	205	and	and	CCONJ
fnp-3806	1	206	emotions	emotion	NOUN
fnp-3806	1	207	–	–	PUNCT
fnp-3806	1	208	the	the	DET
fnp-3806	1	209	very	very	ADJ
fnp-3806	1	210	capacities	capacity	NOUN
fnp-3806	1	211	that	that	PRON
fnp-3806	1	212	distinguish	distinguish	VERB
fnp-3806	1	213	homo	homo	NOUN
fnp-3806	1	214	sapiens	sapiens	ADJ
fnp-3806	1	215	from	from	ADP
fnp-3806	1	216	other	other	ADJ
fnp-3806	1	217	animal	animal	NOUN
fnp-3806	1	218	species	specie	NOUN
fnp-3806	1	219	.	.	PUNCT
fnp-3806	2	1	besides	besides	SCONJ
fnp-3806	2	2	the	the	DET
fnp-3806	2	3	personal	personal	ADJ
fnp-3806	2	4	,	,	PUNCT
fnp-3806	2	5	social	social	ADJ
fnp-3806	2	6	,	,	PUNCT
fnp-3806	2	7	and	and	CCONJ
fnp-3806	2	8	economical	economical	ADJ
fnp-3806	2	9	costs	cost	NOUN
fnp-3806	2	10	,	,	PUNCT
fnp-3806	2	11	late	late	ADJ
fnp-3806	2	12	stages	stage	NOUN
fnp-3806	2	13	of	of	ADP
fnp-3806	2	14	ad	ad	NOUN
fnp-3806	2	15	are	be	AUX
fnp-3806	2	16	vivid	vivid	ADJ
fnp-3806	2	17	experiences	experience	NOUN
fnp-3806	2	18	for	for	ADP
fnp-3806	2	19	the	the	DET
fnp-3806	2	20	family	family	NOUN
fnp-3806	2	21	,	,	PUNCT
fnp-3806	2	22	relatives	relative	NOUN
fnp-3806	2	23	,	,	PUNCT
fnp-3806	2	24	friends	friend	NOUN
fnp-3806	2	25	,	,	PUNCT
fnp-3806	2	26	and	and	CCONJ
fnp-3806	2	27	general	general	ADJ
fnp-3806	2	28	observers	observer	NOUN
fnp-3806	2	29	of	of	ADP
fnp-3806	2	30	the	the	DET
fnp-3806	2	31	progressive	progressive	ADJ
fnp-3806	2	32	ruin	ruin	NOUN
fnp-3806	2	33	of	of	ADP
fnp-3806	2	34	an	an	DET
fnp-3806	2	35	individual	individual	NOUN
fnp-3806	2	36	who	who	PRON
fnp-3806	2	37	turns	turn	VERB
fnp-3806	2	38	into	into	ADP
fnp-3806	2	39	a	a	DET
fnp-3806	2	40	being	being	NOUN
fnp-3806	2	41	with	with	ADP
fnp-3806	2	42	lower	low	ADJ
fnp-3806	2	43	mental	mental	ADJ
fnp-3806	2	44	and	and	CCONJ
fnp-3806	2	45	physical	physical	ADJ
fnp-3806	2	46	capacities	capacity	NOUN
fnp-3806	2	47	than	than	ADP
fnp-3806	2	48	less	less	ADJ
fnp-3806	2	49	evolved	evolved	ADJ
fnp-3806	2	50	species	specie	NOUN
fnp-3806	2	51	.	.	PUNCT
fnp-3806	3	1	a	a	DET
fnp-3806	3	2	human	human	ADJ
fnp-3806	3	3	brain	brain	NOUN
fnp-3806	3	4	with	with	ADP
fnp-3806	3	5	healthy	healthy	ADJ
fnp-3806	3	6	cognition	cognition	NOUN
fnp-3806	3	7	,	,	PUNCT
fnp-3806	3	8	conscience	conscience	NOUN
fnp-3806	3	9	,	,	PUNCT
fnp-3806	3	10	and	and	CCONJ
fnp-3806	3	11	emotions	emotion	NOUN
fnp-3806	3	12	can	can	AUX
fnp-3806	3	13	succeed	succeed	VERB
fnp-3806	3	14	in	in	ADP
fnp-3806	3	15	dealing	deal	VERB
fnp-3806	3	16	with	with	ADP
fnp-3806	3	17	most	most	ADJ
fnp-3806	3	18	difficulties	difficulty	NOUN
fnp-3806	3	19	that	that	PRON
fnp-3806	3	20	life	life	NOUN
fnp-3806	3	21	may	may	AUX
fnp-3806	3	22	pose	pose	VERB
fnp-3806	3	23	.	.	PUNCT
fnp-3806	4	1	without	without	ADP
fnp-3806	4	2	these	these	DET
fnp-3806	4	3	capacities	capacity	NOUN
fnp-3806	4	4	,	,	PUNCT
fnp-3806	4	5	the	the	DET
fnp-3806	4	6	same	same	ADJ
fnp-3806	4	7	person	person	NOUN
fnp-3806	4	8	probably	probably	ADV
fnp-3806	4	9	can	can	AUX
fnp-3806	4	10	not	not	PART
fnp-3806	4	11	.	.	PUNCT
fnp-3806	5	1	due	due	ADJ
fnp-3806	5	2	,	,	PUNCT
fnp-3806	5	3	in	in	ADP
fnp-3806	5	4	part	part	NOUN
fnp-3806	5	5	,	,	PUNCT
fnp-3806	5	6	to	to	ADP
fnp-3806	5	7	this	this	DET
fnp-3806	5	8	emotional	emotional	ADJ
fnp-3806	5	9	impact	impact	NOUN
fnp-3806	5	10	,	,	PUNCT
fnp-3806	5	11	the	the	DET
fnp-3806	5	12	absorbing	absorb	VERB
fnp-3806	5	13	study	study	NOUN
fnp-3806	5	14	of	of	ADP
fnp-3806	5	15	ad	ad	NOUN
fnp-3806	5	16	has	have	AUX
fnp-3806	5	17	generated	generate	VERB
fnp-3806	5	18	,	,	PUNCT
fnp-3806	5	19	over	over	ADP
fnp-3806	5	20	the	the	DET
fnp-3806	5	21	years	year	NOUN
fnp-3806	5	22	,	,	PUNCT
fnp-3806	5	23	a	a	DET
fnp-3806	5	24	fascinating	fascinating	ADJ
fnp-3806	5	25	and	and	CCONJ
fnp-3806	5	26	complex	complex	ADJ
fnp-3806	5	27	story	story	NOUN
fnp-3806	5	28	of	of	ADP
fnp-3806	5	29	theories	theory	NOUN
fnp-3806	5	30	,	,	PUNCT
fnp-3806	5	31	hypotheses	hypothesis	NOUN
fnp-3806	5	32	,	,	PUNCT
fnp-3806	5	33	controversies	controversy	NOUN
fnp-3806	5	34	,	,	PUNCT
fnp-3806	5	35	fashion	fashion	NOUN
fnp-3806	5	36	swings	swing	NOUN
fnp-3806	5	37	,	,	PUNCT
fnp-3806	5	38	and	and	CCONJ
fnp-3806	5	39	passionate	passionate	ADJ
fnp-3806	5	40	clashes	clash	NOUN
fnp-3806	5	41	,	,	PUNCT
fnp-3806	5	42	together	together	ADV
fnp-3806	5	43	with	with	ADP
fnp-3806	5	44	tremendous	tremendous	ADJ
fnp-3806	5	45	efforts	effort	NOUN
fnp-3806	5	46	and	and	CCONJ
fnp-3806	5	47	achievements	achievement	NOUN
fnp-3806	5	48	geared	gear	VERB
fnp-3806	5	49	to	to	PART
fnp-3806	5	50	improve	improve	VERB
fnp-3806	5	51	understanding	understanding	NOUN
fnp-3806	5	52	of	of	ADP
fnp-3806	5	53	the	the	DET
fnp-3806	5	54	pathogenesis	pathogenesis	NOUN
fnp-3806	5	55	and	and	CCONJ
fnp-3806	5	56	treatment	treatment	NOUN
fnp-3806	5	57	of	of	ADP
fnp-3806	5	58	the	the	DET
fnp-3806	5	59	disorder	disorder	NOUN
fnp-3806	5	60	.	.	PUNCT
fnp-3806	6	1	familal	familal	NOUN
fnp-3806	6	2	ad	ad	NOUN
fnp-3806	6	3	is	be	AUX
fnp-3806	6	4	rare	rare	ADJ
fnp-3806	6	5	and	and	CCONJ
fnp-3806	6	6	linked	link	VERB
fnp-3806	6	7	to	to	PART
fnp-3806	6	8	altered	alter	VERB
fnp-3806	6	9	genetic	genetic	ADJ
fnp-3806	6	10	information	information	NOUN
fnp-3806	6	11	associated	associate	VERB
fnp-3806	6	12	with	with	ADP
fnp-3806	6	13	three	three	NUM
fnp-3806	6	14	genes	gene	NOUN
fnp-3806	6	15	.	.	PUNCT
fnp-3806	7	1	sporadic	sporadic	ADJ
fnp-3806	7	2	ad	ad	NOUN
fnp-3806	7	3	(	(	PUNCT
fnp-3806	7	4	sad	sad	ADJ
fnp-3806	7	5	)	)	PUNCT
fnp-3806	7	6	is	be	AUX
fnp-3806	7	7	much	much	ADV
fnp-3806	7	8	more	more	ADV
fnp-3806	7	9	common	common	ADJ
fnp-3806	7	10	and	and	CCONJ
fnp-3806	7	11	multifactorial	multifactorial	ADJ
fnp-3806	7	12	.	.	PUNCT
fnp-3806	8	1	a	a	DET
fnp-3806	8	2	major	major	ADJ
fnp-3806	8	3	point	point	NOUN
fnp-3806	8	4	of	of	ADP
fnp-3806	8	5	clinical	clinical	ADJ
fnp-3806	8	6	discussion	discussion	NOUN
fnp-3806	8	7	has	have	AUX
fnp-3806	8	8	been	be	AUX
fnp-3806	8	9	,	,	PUNCT
fnp-3806	8	10	and	and	CCONJ
fnp-3806	8	11	still	still	ADV
fnp-3806	8	12	is	be	AUX
fnp-3806	8	13	,	,	PUNCT
fnp-3806	8	14	establishing	establish	VERB
fnp-3806	8	15	the	the	DET
fnp-3806	8	16	differences	difference	NOUN
fnp-3806	8	17	between	between	ADP
fnp-3806	8	18	brain	brain	NOUN
fnp-3806	8	19	aging	aging	NOUN
fnp-3806	8	20	and	and	CCONJ
fnp-3806	8	21	sad	sad	ADJ
fnp-3806	8	22	.	.	PUNCT
fnp-3806	9	1	this	this	PRON
fnp-3806	9	2	is	be	AUX
fnp-3806	9	3	not	not	PART
fnp-3806	9	4	a	a	DET
fnp-3806	9	5	trivial	trivial	ADJ
fnp-3806	9	6	question	question	NOUN
fnp-3806	9	7	,	,	PUNCT
fnp-3806	9	8	as	as	SCONJ
fnp-3806	9	9	the	the	DET
fnp-3806	9	10	neuropathological	neuropathological	ADJ
fnp-3806	9	11	and	and	CCONJ
fnp-3806	9	12	molecular	molecular	ADJ
fnp-3806	9	13	characteristics	characteristic	NOUN
fnp-3806	9	14	of	of	ADP
fnp-3806	9	15	normal	normal	ADJ
fnp-3806	9	16	brain	brain	NOUN
fnp-3806	9	17	aging	aging	NOUN
fnp-3806	9	18	and	and	CCONJ
fnp-3806	9	19	the	the	DET
fnp-3806	9	20	first	first	ADJ
fnp-3806	9	21	appearance	appearance	NOUN
fnp-3806	9	22	of	of	ADP
fnp-3806	9	23	early	early	ADJ
fnp-3806	9	24	stages	stage	NOUN
fnp-3806	9	25	of	of	ADP
fnp-3806	9	26	sad	sad	ADJ
fnp-3806	9	27	-	-	PUNCT
fnp-3806	9	28	related	relate	VERB
fnp-3806	9	29	pathology	pathology	NOUN
fnp-3806	9	30	are	be	AUX
fnp-3806	9	31	not	not	PART
fnp-3806	9	32	easily	easily	ADV
fnp-3806	9	33	distinguishable	distinguishable	ADJ
fnp-3806	9	34	in	in	ADP
fnp-3806	9	35	most	most	ADJ
fnp-3806	9	36	individuals	individual	NOUN
fnp-3806	9	37	.	.	PUNCT
fnp-3806	10	1	another	another	DET
fnp-3806	10	2	important	important	ADJ
fnp-3806	10	3	point	point	NOUN
fnp-3806	10	4	is	be	AUX
fnp-3806	10	5	confidence	confidence	NOUN
fnp-3806	10	6	in	in	ADP
fnp-3806	10	7	assigning	assign	VERB
fnp-3806	10	8	responsibility	responsibility	NOUN
fnp-3806	10	9	for	for	ADP
fnp-3806	10	10	the	the	DET
fnp-3806	10	11	beginning	beginning	NOUN
fnp-3806	10	12	of	of	ADP
fnp-3806	10	13	sad	sad	ADJ
fnp-3806	10	14	to	to	ADP
fnp-3806	10	15	a	a	DET
fnp-3806	10	16	few	few	ADJ
fnp-3806	10	17	triggering	trigger	VERB
fnp-3806	10	18	molecules	molecule	NOUN
fnp-3806	10	19	,	,	PUNCT
fnp-3806	10	20	without	without	ADP
fnp-3806	10	21	considering	consider	VERB
fnp-3806	10	22	the	the	DET
fnp-3806	10	23	wide	wide	ADJ
fnp-3806	10	24	number	number	NOUN
fnp-3806	10	25	of	of	ADP
fnp-3806	10	26	alterations	alteration	NOUN
fnp-3806	10	27	that	that	PRON
fnp-3806	10	28	converge	converge	VERB
fnp-3806	10	29	in	in	ADP
fnp-3806	10	30	the	the	DET
fnp-3806	10	31	pathogenesis	pathogenesis	NOUN
fnp-3806	10	32	of	of	ADP
fnp-3806	10	33	aging	aging	NOUN
fnp-3806	10	34	and	and	CCONJ
fnp-3806	10	35	sad	sad	ADJ
fnp-3806	10	36	.	.	PUNCT
fnp-3806	11	1	genetic	genetic	ADJ
fnp-3806	11	2	risk	risk	NOUN
fnp-3806	11	3	factors	factor	NOUN
fnp-3806	11	4	covering	cover	VERB
fnp-3806	11	5	multiple	multiple	ADJ
fnp-3806	11	6	molecular	molecular	ADJ
fnp-3806	11	7	signals	signal	NOUN
fnp-3806	11	8	are	be	AUX
fnp-3806	11	9	increasing	increase	VERB
fnp-3806	11	10	in	in	ADP
fnp-3806	11	11	number	number	NOUN
fnp-3806	11	12	.	.	PUNCT
fnp-3806	12	1	in	in	ADP
fnp-3806	12	2	the	the	DET
fnp-3806	12	3	same	same	ADJ
fnp-3806	12	4	line	line	NOUN
fnp-3806	12	5	,	,	PUNCT
fnp-3806	12	6	molecular	molecular	ADJ
fnp-3806	12	7	pathways	pathway	NOUN
fnp-3806	12	8	are	be	AUX
fnp-3806	12	9	altered	alter	VERB
fnp-3806	12	10	at	at	ADP
fnp-3806	12	11	early	early	ADJ
fnp-3806	12	12	stages	stage	NOUN
fnp-3806	12	13	of	of	ADP
fnp-3806	12	14	sad	sad	ADJ
fnp-3806	12	15	pathology	pathology	NOUN
fnp-3806	12	16	,	,	PUNCT
fnp-3806	12	17	currently	currently	ADV
fnp-3806	12	18	grouped	group	VERB
fnp-3806	12	19	under	under	ADP
fnp-3806	12	20	the	the	DET
fnp-3806	12	21	aegis	aegis	NOUN
fnp-3806	12	22	of	of	ADP
fnp-3806	12	23	normal	normal	ADJ
fnp-3806	12	24	brain	brain	NOUN
fnp-3806	12	25	aging	aging	NOUN
fnp-3806	12	26	,	,	PUNCT
fnp-3806	12	27	only	only	ADV
fnp-3806	12	28	to	to	PART
fnp-3806	12	29	increase	increase	VERB
fnp-3806	12	30	massively	massively	ADV
fnp-3806	12	31	at	at	ADP
fnp-3806	12	32	advanced	advanced	ADJ
fnp-3806	12	33	stages	stage	NOUN
fnp-3806	12	34	of	of	ADP
fnp-3806	12	35	the	the	DET
fnp-3806	12	36	process	process	NOUN
fnp-3806	12	37	.	.	PUNCT
fnp-3806	13	1	sporadic	sporadic	ADJ
fnp-3806	13	2	ad	ad	NOUN
fnp-3806	13	3	is	be	AUX
fnp-3806	13	4	here	here	ADV
fnp-3806	13	5	considered	consider	VERB
fnp-3806	13	6	an	an	DET
fnp-3806	13	7	inherent	inherent	ADJ
fnp-3806	13	8	,	,	PUNCT
fnp-3806	13	9	natural	natural	ADJ
fnp-3806	13	10	part	part	NOUN
fnp-3806	13	11	of	of	ADP
fnp-3806	13	12	human	human	ADJ
fnp-3806	13	13	brain	brain	NOUN
fnp-3806	13	14	aging	aging	NOUN
fnp-3806	13	15	,	,	PUNCT
fnp-3806	13	16	which	which	PRON
fnp-3806	13	17	is	be	AUX
fnp-3806	13	18	prevalent	prevalent	ADJ
fnp-3806	13	19	in	in	ADP
fnp-3806	13	20	all	all	DET
fnp-3806	13	21	humans	human	NOUN
fnp-3806	13	22	,	,	PUNCT
fnp-3806	13	23	and	and	CCONJ
fnp-3806	13	24	variably	variably	ADV
fnp-3806	13	25	present	present	ADJ
fnp-3806	13	26	or	or	CCONJ
fnp-3806	13	27	not	not	PART
fnp-3806	13	28	in	in	ADP
fnp-3806	13	29	a	a	DET
fnp-3806	13	30	few	few	ADJ
fnp-3806	13	31	individuals	individual	NOUN
fnp-3806	13	32	in	in	ADP
fnp-3806	13	33	other	other	ADJ
fnp-3806	13	34	species	specie	NOUN
fnp-3806	13	35	.	.	PUNCT
fnp-3806	14	1	the	the	DET
fnp-3806	14	2	progression	progression	NOUN
fnp-3806	14	3	of	of	ADP
fnp-3806	14	4	the	the	DET
fnp-3806	14	5	process	process	NOUN
fnp-3806	14	6	has	have	VERB
fnp-3806	14	7	devastating	devastating	ADJ
fnp-3806	14	8	effects	effect	NOUN
fnp-3806	14	9	in	in	ADP
fnp-3806	14	10	a	a	DET
fnp-3806	14	11	relatively	relatively	ADV
fnp-3806	14	12	low	low	ADJ
fnp-3806	14	13	percentage	percentage	NOUN
fnp-3806	14	14	of	of	ADP
fnp-3806	14	15	human	human	ADJ
fnp-3806	14	16	beings	being	NOUN
fnp-3806	14	17	eventually	eventually	ADV
fnp-3806	14	18	evolving	evolve	VERB
fnp-3806	14	19	to	to	ADP
fnp-3806	14	20	dementia	dementia	NOUN
fnp-3806	14	21	.	.	PUNCT
fnp-3806	15	1	the	the	DET
fnp-3806	15	2	continuum	continuum	NOUN
fnp-3806	15	3	of	of	ADP
fnp-3806	15	4	brain	brain	NOUN
fnp-3806	15	5	aging	aging	NOUN
fnp-3806	15	6	and	and	CCONJ
fnp-3806	15	7	sad	sad	ADJ
fnp-3806	15	8	implies	imply	VERB
fnp-3806	15	9	the	the	DET
fnp-3806	15	10	search	search	NOUN
fnp-3806	15	11	for	for	ADP
fnp-3806	15	12	a	a	DET
fnp-3806	15	13	different	different	ADJ
fnp-3806	15	14	approach	approach	NOUN
fnp-3806	15	15	in	in	ADP
fnp-3806	15	16	the	the	DET
fnp-3806	15	17	study	study	NOUN
fnp-3806	15	18	of	of	ADP
fnp-3806	15	19	human	human	ADJ
fnp-3806	15	20	brain	brain	NOUN
fnp-3806	15	21	aging	aging	NOUN
fnp-3806	15	22	at	at	ADP
fnp-3806	15	23	the	the	DET
fnp-3806	15	24	first	first	ADJ
fnp-3806	15	25	stages	stage	NOUN
fnp-3806	15	26	of	of	ADP
fnp-3806	15	27	the	the	DET
fnp-3806	15	28	biological	biological	ADJ
fnp-3806	15	29	process	process	NOUN
fnp-3806	15	30	,	,	PUNCT
fnp-3806	15	31	and	and	CCONJ
fnp-3806	15	32	advances	advance	NOUN
fnp-3806	15	33	in	in	ADP
fnp-3806	15	34	the	the	DET
fnp-3806	15	35	use	use	NOUN
fnp-3806	15	36	of	of	ADP
fnp-3806	15	37	new	new	ADJ
fnp-3806	15	38	technologies	technology	NOUN
fnp-3806	15	39	aimed	aim	VERB
fnp-3806	15	40	at	at	ADP
fnp-3806	15	41	slowing	slow	VERB
fnp-3806	15	42	down	down	ADP
fnp-3806	15	43	the	the	DET
fnp-3806	15	44	molecular	molecular	ADJ
fnp-3806	15	45	defects	defect	NOUN
fnp-3806	15	46	underlying	underlie	VERB
fnp-3806	15	47	human	human	ADJ
fnp-3806	15	48	brain	brain	NOUN
fnp-3806	15	49	aging	aging	NOUN
fnp-3806	15	50	and	and	CCONJ
fnp-3806	15	51	sad	sad	ADJ
fnp-3806	15	52	at	at	ADP
fnp-3806	15	53	the	the	DET
fnp-3806	15	54	outset	outset	NOUN
fnp-3806	15	55	,	,	PUNCT
fnp-3806	15	56	and	and	CCONJ
fnp-3806	15	57	transfering	transfer	VERB
fnp-3806	15	58	information	information	NOUN
fnp-3806	15	59	and	and	CCONJ
fnp-3806	15	60	tasks	task	NOUN
fnp-3806	15	61	to	to	PART
fnp-3806	15	62	ai	ai	VERB
fnp-3806	15	63	and	and	CCONJ
fnp-3806	15	64	coordinated	coordinated	ADJ
fnp-3806	15	65	devices	device	NOUN
fnp-3806	15	66	.	.	PUNCT
fnp-3806	16	1	index	index	NOUN
fnp-3806	16	2	summary	summary	NOUN
fnp-3806	16	3	1	1	NUM
fnp-3806	16	4	.	.	PUNCT
fnp-3806	16	5	introduction	introduction	NOUN
fnp-3806	16	6	2	2	NUM
fnp-3806	16	7	.	.	PUNCT
fnp-3806	17	1	β	β	X
fnp-3806	17	2	-	-	PUNCT
fnp-3806	17	3	amyloid	amyloid	NOUN
fnp-3806	17	4	and	and	CCONJ
fnp-3806	17	5	tau	tau	PROPN
fnp-3806	17	6	2a	2a	NUM
fnp-3806	17	7	.	.	PUNCT
fnp-3806	18	1	β	β	X
fnp-3806	18	2	-	-	PUNCT
fnp-3806	18	3	amyloid	amyloid	NOUN
fnp-3806	18	4	(	(	PUNCT
fnp-3806	18	5	aβ	aβ	NOUN
fnp-3806	18	6	)	)	PUNCT
fnp-3806	18	7	2b	2b	NOUN
fnp-3806	18	8	.	.	PUNCT
fnp-3806	19	1	tau	tau	PROPN
fnp-3806	19	2	3	3	NUM
fnp-3806	19	3	.	.	PUNCT
fnp-3806	19	4	familial	familial	ADJ
fnp-3806	19	5	ad	ad	NOUN
fnp-3806	19	6	(	(	PUNCT
fnp-3806	19	7	fad	fad	NOUN
fnp-3806	19	8	;	;	PUNCT
fnp-3806	19	9	early	early	ADJ
fnp-3806	19	10	-	-	PUNCT
fnp-3806	19	11	onset	onset	NOUN
fnp-3806	19	12	familial	familial	ADJ
fnp-3806	19	13	alzheimer	alzheimer	PROPN
fnp-3806	19	14	’s	’s	PART
fnp-3806	19	15	disease	disease	NOUN
fnp-3806	19	16	:	:	PUNCT
fnp-3806	19	17	eofad	eofad	NOUN
fnp-3806	19	18	)	)	PUNCT
fnp-3806	19	19	,	,	PUNCT
fnp-3806	19	20	and	and	CCONJ
fnp-3806	19	21	the	the	DET
fnp-3806	19	22	β	β	NOUN
fnp-3806	19	23	-	-	ADJ
fnp-3806	19	24	amyloid	amyloid	ADJ
fnp-3806	19	25	cascade	cascade	NOUN
fnp-3806	19	26	hypothesis	hypothesis	NOUN
fnp-3806	19	27	4	4	NUM
fnp-3806	19	28	.	.	PUNCT
fnp-3806	19	29	sporadic	sporadic	ADJ
fnp-3806	19	30	ad	ad	NOUN
fnp-3806	19	31	(	(	PUNCT
fnp-3806	19	32	sad	sad	ADJ
fnp-3806	19	33	;	;	PUNCT
fnp-3806	19	34	late	late	ADJ
fnp-3806	19	35	-	-	PUNCT
fnp-3806	19	36	onset	onset	NOUN
fnp-3806	19	37	alzheimer	alzheimer	NOUN
fnp-3806	19	38	disease	disease	NOUN
fnp-3806	19	39	:	:	PUNCT
fnp-3806	19	40	load	load	NOUN
fnp-3806	19	41	)	)	PUNCT
fnp-3806	19	42	5	5	NUM
fnp-3806	19	43	.	.	NOUN
fnp-3806	19	44	nfts	nft	NOUN
fnp-3806	19	45	and	and	CCONJ
fnp-3806	19	46	sps	sps	PROPN
fnp-3806	19	47	in	in	ADP
fnp-3806	19	48	non	non	ADJ
fnp-3806	19	49	-	-	ADJ
fnp-3806	19	50	human	human	ADJ
fnp-3806	19	51	brain	brain	NOUN
fnp-3806	19	52	aging	age	VERB
fnp-3806	19	53	6	6	NUM
fnp-3806	19	54	.	.	PUNCT
fnp-3806	19	55	synapses	synapse	VERB
fnp-3806	19	56	7	7	NUM
fnp-3806	19	57	.	.	PUNCT
fnp-3806	19	58	neurotransmitters	neurotransmitter	NOUN
fnp-3806	19	59	,	,	PUNCT
fnp-3806	19	60	neuromodulators	neuromodulator	NOUN
fnp-3806	19	61	,	,	PUNCT
fnp-3806	19	62	and	and	CCONJ
fnp-3806	19	63	related	related	ADJ
fnp-3806	19	64	receptors	receptor	NOUN
fnp-3806	19	65	7a	7a	NOUN
fnp-3806	19	66	.	.	PUNCT
fnp-3806	20	1	acetylcholine	acetylcholine	NOUN
fnp-3806	20	2	(	(	PUNCT
fnp-3806	20	3	ach	ach	PROPN
fnp-3806	20	4	)	)	PUNCT
fnp-3806	20	5	and	and	CCONJ
fnp-3806	20	6	acetylcholine	acetylcholine	NOUN
fnp-3806	20	7	receptors	receptor	NOUN
fnp-3806	20	8	(	(	PUNCT
fnp-3806	20	9	achr	achr	NOUN
fnp-3806	20	10	)	)	PUNCT
fnp-3806	21	1	7b	7b	NOUN
fnp-3806	21	2	.	.	PUNCT
fnp-3806	22	1	glutamate	glutamate	NOUN
fnp-3806	22	2	and	and	CCONJ
fnp-3806	22	3	glutamate	glutamate	ADJ
fnp-3806	22	4	receptors	receptor	NOUN
fnp-3806	22	5	(	(	PUNCT
fnp-3806	22	6	glurs	glur	NOUN
fnp-3806	22	7	)	)	PUNCT
fnp-3806	22	8	7c	7c	NOUN
fnp-3806	22	9	.	.	PUNCT
fnp-3806	23	1	γ	γ	X
fnp-3806	23	2	-	-	ADJ
fnp-3806	23	3	aminobutyric	aminobutyric	ADJ
fnp-3806	23	4	acid	acid	NOUN
fnp-3806	23	5	(	(	PUNCT
fnp-3806	23	6	gaba	gaba	PROPN
fnp-3806	23	7	)	)	PUNCT
fnp-3806	23	8	and	and	CCONJ
fnp-3806	23	9	gaba	gaba	NOUN
fnp-3806	23	10	receptors	receptor	NOUN
fnp-3806	23	11	7d	7d	NUM
fnp-3806	23	12	.	.	PUNCT
fnp-3806	23	13	serotonin	serotonin	VERB
fnp-3806	23	14	and	and	CCONJ
fnp-3806	23	15	5	5	NUM
fnp-3806	23	16	-	-	PUNCT
fnp-3806	23	17	hydroxytryptamine	hydroxytryptamine	NOUN
fnp-3806	23	18	(	(	PUNCT
fnp-3806	23	19	5	5	NUM
fnp-3806	23	20	-	-	PUNCT
fnp-3806	23	21	ht	ht	NOUN
fnp-3806	23	22	)	)	PUNCT
fnp-3806	23	23	receptors	receptor	NOUN
fnp-3806	23	24	7e	7e	NUM
fnp-3806	23	25	.	.	PUNCT
fnp-3806	24	1	noradrenergic	noradrenergic	ADJ
fnp-3806	24	2	system	system	NOUN
fnp-3806	24	3	7f	7f	X
fnp-3806	24	4	.	.	PUNCT
fnp-3806	25	1	adenosine	adenosine	NOUN
fnp-3806	25	2	receptors	receptor	NOUN
fnp-3806	25	3	7	7	NUM
fnp-3806	25	4	g.	g.	NOUN
fnp-3806	25	5	endocannabinoids	endocannabinoid	NOUN
fnp-3806	25	6	and	and	CCONJ
fnp-3806	25	7	cannabinoid	cannabinoid	NOUN
fnp-3806	25	8	receptors	receptor	NOUN
fnp-3806	25	9	(	(	PUNCT
fnp-3806	25	10	cbrs	cbrs	NOUN
fnp-3806	25	11	)	)	PUNCT
fnp-3806	25	12	8	8	NUM
fnp-3806	25	13	.	.	PUNCT
fnp-3806	25	14	trophic	trophic	ADJ
fnp-3806	25	15	factors	factor	NOUN
fnp-3806	25	16	and	and	CCONJ
fnp-3806	25	17	receptors	receptor	NOUN
fnp-3806	25	18	9	9	NUM
fnp-3806	25	19	.	.	PUNCT
fnp-3806	25	20	endoplasmic	endoplasmic	ADJ
fnp-3806	25	21	reticulum	reticulum	NOUN
fnp-3806	25	22	stress	stress	NOUN
fnp-3806	25	23	10	10	NUM
fnp-3806	25	24	.	.	PUNCT
fnp-3806	26	1	failure	failure	NOUN
fnp-3806	26	2	to	to	PART
fnp-3806	26	3	remove	remove	VERB
fnp-3806	26	4	debris	debris	NOUN
fnp-3806	26	5	:	:	PUNCT
fnp-3806	26	6	the	the	DET
fnp-3806	26	7	ubiquitin	ubiquitin	ADJ
fnp-3806	26	8	-	-	PUNCT
fnp-3806	26	9	proteasome	proteasome	NOUN
fnp-3806	26	10	system	system	NOUN
fnp-3806	26	11	(	(	PUNCT
fnp-3806	26	12	ups	up	NOUN
fnp-3806	26	13	)	)	PUNCT
fnp-3806	26	14	and	and	CCONJ
fnp-3806	26	15	autophagy	autophagy	VERB
fnp-3806	26	16	in	in	ADP
fnp-3806	26	17	sad	sad	ADJ
fnp-3806	26	18	11	11	NUM
fnp-3806	26	19	.	.	PUNCT
fnp-3806	27	1	granulovacuolar	granulovacuolar	ADJ
fnp-3806	27	2	degeneration	degeneration	NOUN
fnp-3806	27	3	(	(	PUNCT
fnp-3806	27	4	gvd	gvd	PROPN
fnp-3806	27	5	)	)	PUNCT
fnp-3806	27	6	12	12	NUM
fnp-3806	27	7	.	.	PUNCT
fnp-3806	28	1	glial	glial	ADJ
fnp-3806	28	2	alterations	alteration	NOUN
fnp-3806	28	3	in	in	ADP
fnp-3806	28	4	aging	age	VERB
fnp-3806	28	5	and	and	CCONJ
fnp-3806	28	6	sad	sad	ADJ
fnp-3806	28	7	12a	12a	NOUN
fnp-3806	28	8	.	.	PUNCT
fnp-3806	28	9	astrocytes	astrocyte	NOUN
fnp-3806	28	10	12b	12b	NOUN
fnp-3806	28	11	.	.	PUNCT
fnp-3806	29	1	microglia	microglia	ADJ
fnp-3806	29	2	12c	12c	NUM
fnp-3806	29	3	.	.	PUNCT
fnp-3806	30	1	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	30	2	13	13	NUM
fnp-3806	30	3	.	.	PUNCT
fnp-3806	31	1	the	the	DET
fnp-3806	31	2	neurovascular	neurovascular	ADJ
fnp-3806	31	3	system	system	NOUN
fnp-3806	31	4	in	in	ADP
fnp-3806	31	5	ad	ad	NOUN
fnp-3806	31	6	14	14	NUM
fnp-3806	31	7	.	.	PUNCT
fnp-3806	32	1	purine	purine	NOUN
fnp-3806	32	2	and	and	CCONJ
fnp-3806	32	3	pyrimidine	pyrimidine	NOUN
fnp-3806	32	4	metabolism	metabolism	NOUN
fnp-3806	32	5	in	in	ADP
fnp-3806	32	6	sad	sad	ADJ
fnp-3806	32	7	15	15	NUM
fnp-3806	32	8	.	.	PUNCT
fnp-3806	33	1	epigenetics	epigenetic	NOUN
fnp-3806	33	2	in	in	ADP
fnp-3806	33	3	brain	brain	NOUN
fnp-3806	33	4	aging	aging	NOUN
fnp-3806	33	5	and	and	CCONJ
fnp-3806	33	6	sad	sad	ADJ
fnp-3806	33	7	15a	15a	NOUN
fnp-3806	33	8	.	.	PUNCT
fnp-3806	34	1	histone	histone	NOUN
fnp-3806	34	2	modifications	modification	NOUN
fnp-3806	34	3	,	,	PUNCT
fnp-3806	34	4	dna	dna	PROPN
fnp-3806	34	5	methylation	methylation	NOUN
fnp-3806	34	6	,	,	PUNCT
fnp-3806	34	7	and	and	CCONJ
fnp-3806	34	8	hydroxymethylation	hydroxymethylation	NOUN
fnp-3806	34	9	15b	15b	NOUN
fnp-3806	34	10	.	.	PUNCT
fnp-3806	35	1	non	non	ADJ
fnp-3806	35	2	-	-	ADJ
fnp-3806	35	3	coding	coding	ADJ
fnp-3806	35	4	rnas	rna	NOUN
fnp-3806	35	5	16	16	NUM
fnp-3806	35	6	.	.	PUNCT
fnp-3806	36	1	microorganisms	microorganism	NOUN
fnp-3806	36	2	and	and	CCONJ
fnp-3806	36	3	sad	sad	ADJ
fnp-3806	36	4	16a	16a	NOUN
fnp-3806	36	5	.	.	PUNCT
fnp-3806	37	1	microorganisms	microorganism	NOUN
fnp-3806	37	2	in	in	ADP
fnp-3806	37	3	the	the	DET
fnp-3806	37	4	brain	brain	NOUN
fnp-3806	37	5	and	and	CCONJ
fnp-3806	37	6	oral	oral	ADJ
fnp-3806	37	7	cavity	cavity	NOUN
fnp-3806	37	8	16b	16b	X
fnp-3806	37	9	.	.	PUNCT
fnp-3806	38	1	gut	gut	VERB
fnp-3806	38	2	microbiota	microbiota	NOUN
fnp-3806	38	3	17	17	NUM
fnp-3806	38	4	.	.	PUNCT
fnp-3806	39	1	seeding	seed	VERB
fnp-3806	39	2	and	and	CCONJ
fnp-3806	39	3	spreading	spread	VERB
fnp-3806	39	4	of	of	ADP
fnp-3806	39	5	β	β	NOUN
fnp-3806	39	6	-	-	NOUN
fnp-3806	39	7	amyloid	amyloid	NOUN
fnp-3806	39	8	and	and	CCONJ
fnp-3806	39	9	tau	tau	PROPN
fnp-3806	39	10	17a	17a	PROPN
fnp-3806	39	11	.	.	PUNCT
fnp-3806	40	1	seeding	seed	VERB
fnp-3806	40	2	β	β	NOUN
fnp-3806	40	3	-	-	NOUN
fnp-3806	40	4	amyloid	amyloid	ADJ
fnp-3806	40	5	17b	17b	NUM
fnp-3806	40	6	.	.	PUNCT
fnp-3806	41	1	tau	tau	PROPN
fnp-3806	41	2	seeding	seed	VERB
fnp-3806	41	3	17c	17c	NOUN
fnp-3806	41	4	.	.	PUNCT
fnp-3806	42	1	multiple	multiple	ADJ
fnp-3806	42	2	seeding	seed	VERB
fnp-3806	42	3	foci	focus	NOUN
fnp-3806	42	4	of	of	ADP
fnp-3806	42	5	β	β	NOUN
fnp-3806	42	6	-	-	NOUN
fnp-3806	42	7	amyloid	amyloid	NOUN
fnp-3806	42	8	and	and	CCONJ
fnp-3806	42	9	tau	tau	PROPN
fnp-3806	42	10	pathology	pathology	NOUN
fnp-3806	42	11	;	;	PUNCT
fnp-3806	42	12	vulnerable	vulnerable	ADJ
fnp-3806	42	13	and	and	CCONJ
fnp-3806	42	14	resistant	resistant	ADJ
fnp-3806	42	15	populations	population	NOUN
fnp-3806	42	16	to	to	ADP
fnp-3806	42	17	tau	tau	PROPN
fnp-3806	42	18	seeding	seed	VERB
fnp-3806	42	19	in	in	ADP
fnp-3806	42	20	brain	brain	NOUN
fnp-3806	42	21	aging	aging	NOUN
fnp-3806	42	22	and	and	CCONJ
fnp-3806	42	23	sad	sad	ADJ
fnp-3806	42	24	18	18	NUM
fnp-3806	42	25	.	.	PUNCT
fnp-3806	42	26	neuronal	neuronal	ADJ
fnp-3806	42	27	death	death	NOUN
fnp-3806	42	28	19	19	NUM
fnp-3806	42	29	.	.	PUNCT
fnp-3806	42	30	neuronal	neuronal	ADJ
fnp-3806	42	31	connectivity	connectivity	NOUN
fnp-3806	42	32	networks	network	NOUN
fnp-3806	42	33	in	in	ADP
fnp-3806	42	34	brain	brain	NOUN
fnp-3806	42	35	aging	aging	NOUN
fnp-3806	42	36	and	and	CCONJ
fnp-3806	42	37	sad	sad	ADJ
fnp-3806	42	38	20	20	NUM
fnp-3806	42	39	.	.	PUNCT
fnp-3806	43	1	human	human	ADJ
fnp-3806	43	2	brain	brain	NOUN
fnp-3806	43	3	aging	aging	NOUN
fnp-3806	43	4	and	and	CCONJ
fnp-3806	43	5	preclinical	preclinical	ADJ
fnp-3806	43	6	ad	ad	NOUN
fnp-3806	43	7	21	21	NUM
fnp-3806	43	8	.	.	PUNCT
fnp-3806	44	1	primary	primary	ADJ
fnp-3806	44	2	age	age	NOUN
fnp-3806	44	3	-	-	PUNCT
fnp-3806	44	4	related	relate	VERB
fnp-3806	44	5	tauopathy	tauopathy	NOUN
fnp-3806	44	6	(	(	PUNCT
fnp-3806	44	7	part	part	NOUN
fnp-3806	44	8	)	)	PUNCT
fnp-3806	44	9	,	,	PUNCT
fnp-3806	44	10	rapidly	rapidly	ADV
fnp-3806	44	11	progressive	progressive	ADJ
fnp-3806	44	12	sad	sad	ADJ
fnp-3806	44	13	,	,	PUNCT
fnp-3806	44	14	and	and	CCONJ
fnp-3806	44	15	sad	sad	ADJ
fnp-3806	44	16	resilience	resilience	NOUN
fnp-3806	44	17	21a	21a	NUM
fnp-3806	44	18	.	.	PUNCT
fnp-3806	45	1	part	part	NOUN
fnp-3806	45	2	21b	21b	NOUN
fnp-3806	45	3	.	.	PUNCT
fnp-3806	46	1	rapidly	rapidly	ADV
fnp-3806	46	2	progressive	progressive	ADJ
fnp-3806	46	3	ad	ad	NOUN
fnp-3806	46	4	21c	21c	NUM
fnp-3806	46	5	.	.	PUNCT
fnp-3806	47	1	sad	sad	ADJ
fnp-3806	47	2	resilience	resilience	NOUN
fnp-3806	47	3	22	22	NUM
fnp-3806	47	4	.	.	PUNCT
fnp-3806	48	1	biochemical	biochemical	ADJ
fnp-3806	48	2	changes	change	NOUN
fnp-3806	48	3	beyond	beyond	ADP
fnp-3806	48	4	tau	tau	PROPN
fnp-3806	48	5	and	and	CCONJ
fnp-3806	48	6	β	β	NOUN
fnp-3806	48	7	-	-	NOUN
fnp-3806	48	8	amyloid	amyloid	NOUN
fnp-3806	48	9	at	at	ADP
fnp-3806	48	10	the	the	DET
fnp-3806	48	11	the	the	DET
fnp-3806	48	12	first	first	ADJ
fnp-3806	48	13	stages	stage	NOUN
fnp-3806	48	14	of	of	ADP
fnp-3806	48	15	nft	nft	PROPN
fnp-3806	48	16	pathology	pathology	PROPN
fnp-3806	48	17	22a	22a	PROPN
fnp-3806	48	18	.	.	PUNCT
fnp-3806	49	1	aberrant	aberrant	ADJ
fnp-3806	49	2	cell	cell	NOUN
fnp-3806	49	3	-	-	PUNCT
fnp-3806	49	4	cycle	cycle	NOUN
fnp-3806	49	5	re	re	NOUN
fnp-3806	49	6	-	-	NOUN
fnp-3806	49	7	entry	entry	NOUN
fnp-3806	49	8	,	,	PUNCT
fnp-3806	49	9	and	and	CCONJ
fnp-3806	49	10	altered	alter	VERB
fnp-3806	49	11	adult	adult	NOUN
fnp-3806	49	12	neurogenesis	neurogenesis	NOUN
fnp-3806	49	13	22b	22b	NUM
fnp-3806	49	14	.	.	PUNCT
fnp-3806	50	1	brain	brain	NOUN
fnp-3806	50	2	lipids	lipid	VERB
fnp-3806	50	3	22c	22c	NOUN
fnp-3806	50	4	.	.	PUNCT
fnp-3806	51	1	lipid	lipid	ADJ
fnp-3806	51	2	rafts	raft	NOUN
fnp-3806	51	3	and	and	CCONJ
fnp-3806	51	4	cell	cell	NOUN
fnp-3806	51	5	membranes	membrane	NOUN
fnp-3806	51	6	22d	22d	NOUN
fnp-3806	51	7	.	.	PUNCT
fnp-3806	52	1	mitochondria	mitochondria	PROPN
fnp-3806	52	2	22e	22e	PROPN
fnp-3806	52	3	.	.	PUNCT
fnp-3806	53	1	oxidative	oxidative	ADJ
fnp-3806	53	2	stress	stress	NOUN
fnp-3806	53	3	damage	damage	NOUN
fnp-3806	53	4	22f	22f	NOUN
fnp-3806	53	5	.	.	PUNCT
fnp-3806	54	1	inflammation	inflammation	NOUN
fnp-3806	54	2	22	22	NUM
fnp-3806	54	3	g.	g.	NOUN
fnp-3806	54	4	protein	protein	NOUN
fnp-3806	54	5	synthesis	synthesis	NOUN
fnp-3806	54	6	impairment	impairment	NOUN
fnp-3806	54	7	22h	22h	NOUN
fnp-3806	54	8	.	.	PUNCT
fnp-3806	55	1	dysregulated	dysregulate	VERB
fnp-3806	55	2	protein	protein	NOUN
fnp-3806	55	3	phosphorylation	phosphorylation	NOUN
fnp-3806	55	4	23	23	NUM
fnp-3806	55	5	.	.	PUNCT
fnp-3806	56	1	concluding	conclude	VERB
fnp-3806	56	2	comments	comment	NOUN
fnp-3806	56	3	abbreviations	abbreviation	NOUN
fnp-3806	56	4	funding	funding	NOUN
fnp-3806	56	5	acknowledgements	acknowledgement	NOUN
fnp-3806	56	6	references	reference	NOUN
fnp-3806	56	7	summary	summary	VERB
fnp-3806	56	8	this	this	PRON
fnp-3806	56	9	is	be	AUX
fnp-3806	56	10	a	a	DET
fnp-3806	56	11	comprehensive	comprehensive	ADJ
fnp-3806	56	12	historical	historical	ADJ
fnp-3806	56	13	and	and	CCONJ
fnp-3806	56	14	up	up	ADV
fnp-3806	56	15	-	-	PUNCT
fnp-3806	56	16	dated	date	VERB
fnp-3806	56	17	review	review	NOUN
fnp-3806	56	18	on	on	ADP
fnp-3806	56	19	the	the	DET
fnp-3806	56	20	pathogenesis	pathogenesis	NOUN
fnp-3806	56	21	of	of	ADP
fnp-3806	56	22	alzheimer	alzheimer	PROPN
fnp-3806	56	23	’s	’s	PART
fnp-3806	56	24	disease	disease	NOUN
fnp-3806	56	25	(	(	PUNCT
fnp-3806	56	26	ad	ad	NOUN
fnp-3806	56	27	)	)	PUNCT
fnp-3806	56	28	in	in	ADP
fnp-3806	56	29	relation	relation	NOUN
fnp-3806	56	30	to	to	ADP
fnp-3806	56	31	intrinsic	intrinsic	ADJ
fnp-3806	56	32	process	process	NOUN
fnp-3806	56	33	of	of	ADP
fnp-3806	56	34	natural	natural	ADJ
fnp-3806	56	35	brain	brain	NOUN
fnp-3806	56	36	aging	aging	NOUN
fnp-3806	56	37	.	.	PUNCT
fnp-3806	57	1	the	the	DET
fnp-3806	57	2	study	study	NOUN
fnp-3806	57	3	covers	cover	VERB
fnp-3806	57	4	,	,	PUNCT
fnp-3806	57	5	in	in	ADP
fnp-3806	57	6	addition	addition	NOUN
fnp-3806	57	7	to	to	ADP
fnp-3806	57	8	β	β	NOUN
fnp-3806	57	9	-	-	NOUN
fnp-3806	57	10	amyloid	amyloid	NOUN
fnp-3806	57	11	and	and	CCONJ
fnp-3806	57	12	tau	tau	PROPN
fnp-3806	57	13	pathology	pathology	NOUN
fnp-3806	57	14	,	,	PUNCT
fnp-3806	57	15	alterations	alteration	NOUN
fnp-3806	57	16	in	in	ADP
fnp-3806	57	17	multiple	multiple	ADJ
fnp-3806	57	18	merging	merge	VERB
fnp-3806	57	19	molecular	molecular	ADJ
fnp-3806	57	20	pathways	pathway	NOUN
fnp-3806	57	21	and	and	CCONJ
fnp-3806	57	22	sub	sub	ADJ
fnp-3806	57	23	-	-	ADJ
fnp-3806	57	24	cellular	cellular	ADJ
fnp-3806	57	25	structures	structure	NOUN
fnp-3806	57	26	underpinning	underpin	VERB
fnp-3806	57	27	brain	brain	NOUN
fnp-3806	57	28	aging	aging	NOUN
fnp-3806	57	29	and	and	CCONJ
fnp-3806	57	30	ad	ad	NOUN
fnp-3806	57	31	.	.	PUNCT
fnp-3806	58	1	familial	familial	ADJ
fnp-3806	58	2	ad	ad	NOUN
fnp-3806	58	3	(	(	PUNCT
fnp-3806	58	4	fad	fad	NOUN
fnp-3806	58	5	)	)	PUNCT
fnp-3806	58	6	is	be	AUX
fnp-3806	58	7	rare	rare	ADJ
fnp-3806	58	8	and	and	CCONJ
fnp-3806	58	9	linked	link	VERB
fnp-3806	58	10	to	to	PART
fnp-3806	58	11	altered	alter	VERB
fnp-3806	58	12	genetic	genetic	ADJ
fnp-3806	58	13	information	information	NOUN
fnp-3806	58	14	associated	associate	VERB
fnp-3806	58	15	with	with	ADP
fnp-3806	58	16	three	three	NUM
fnp-3806	58	17	genes	gene	NOUN
fnp-3806	58	18	.	.	PUNCT
fnp-3806	59	1	sporadic	sporadic	ADJ
fnp-3806	59	2	ad	ad	NOUN
fnp-3806	59	3	(	(	PUNCT
fnp-3806	59	4	sad	sad	ADJ
fnp-3806	59	5	)	)	PUNCT
fnp-3806	59	6	is	be	AUX
fnp-3806	59	7	much	much	ADV
fnp-3806	59	8	more	more	ADV
fnp-3806	59	9	common	common	ADJ
fnp-3806	59	10	and	and	CCONJ
fnp-3806	59	11	multifactorial	multifactorial	ADJ
fnp-3806	59	12	.	.	PUNCT
fnp-3806	60	1	a	a	DET
fnp-3806	60	2	major	major	ADJ
fnp-3806	60	3	point	point	NOUN
fnp-3806	60	4	of	of	ADP
fnp-3806	60	5	clinical	clinical	ADJ
fnp-3806	60	6	discussion	discussion	NOUN
fnp-3806	60	7	has	have	AUX
fnp-3806	60	8	been	be	AUX
fnp-3806	60	9	,	,	PUNCT
fnp-3806	60	10	and	and	CCONJ
fnp-3806	60	11	remains	remain	VERB
fnp-3806	60	12	,	,	PUNCT
fnp-3806	60	13	establishing	establish	VERB
fnp-3806	60	14	the	the	DET
fnp-3806	60	15	differences	difference	NOUN
fnp-3806	60	16	between	between	ADP
fnp-3806	60	17	brain	brain	NOUN
fnp-3806	60	18	aging	aging	NOUN
fnp-3806	60	19	and	and	CCONJ
fnp-3806	60	20	sad	sad	ADJ
fnp-3806	60	21	.	.	PUNCT
fnp-3806	61	1	this	this	PRON
fnp-3806	61	2	is	be	AUX
fnp-3806	61	3	not	not	PART
fnp-3806	61	4	a	a	DET
fnp-3806	61	5	trivial	trivial	ADJ
fnp-3806	61	6	question	question	NOUN
fnp-3806	61	7	,	,	PUNCT
fnp-3806	61	8	as	as	SCONJ
fnp-3806	61	9	the	the	DET
fnp-3806	61	10	neuropathological	neuropathological	ADJ
fnp-3806	61	11	and	and	CCONJ
fnp-3806	61	12	molecular	molecular	ADJ
fnp-3806	61	13	characteristics	characteristic	NOUN
fnp-3806	61	14	of	of	ADP
fnp-3806	61	15	normal	normal	ADJ
fnp-3806	61	16	brain	brain	NOUN
fnp-3806	61	17	aging	aging	NOUN
fnp-3806	61	18	and	and	CCONJ
fnp-3806	61	19	the	the	DET
fnp-3806	61	20	first	first	ADJ
fnp-3806	61	21	appearance	appearance	NOUN
fnp-3806	61	22	of	of	ADP
fnp-3806	61	23	early	early	ADJ
fnp-3806	61	24	stages	stage	NOUN
fnp-3806	61	25	of	of	ADP
fnp-3806	61	26	sad	sad	ADJ
fnp-3806	61	27	-	-	PUNCT
fnp-3806	61	28	related	relate	VERB
fnp-3806	61	29	pathology	pathology	NOUN
fnp-3806	61	30	are	be	AUX
fnp-3806	61	31	not	not	PART
fnp-3806	61	32	easily	easily	ADV
fnp-3806	61	33	distinguishable	distinguishable	ADJ
fnp-3806	61	34	in	in	ADP
fnp-3806	61	35	most	most	ADJ
fnp-3806	61	36	individuals	individual	NOUN
fnp-3806	61	37	.	.	PUNCT
fnp-3806	62	1	another	another	DET
fnp-3806	62	2	important	important	ADJ
fnp-3806	62	3	point	point	NOUN
fnp-3806	62	4	is	be	AUX
fnp-3806	62	5	confidence	confidence	NOUN
fnp-3806	62	6	in	in	ADP
fnp-3806	62	7	assigning	assign	VERB
fnp-3806	62	8	responsibility	responsibility	NOUN
fnp-3806	62	9	for	for	ADP
fnp-3806	62	10	the	the	DET
fnp-3806	62	11	beginning	beginning	NOUN
fnp-3806	62	12	of	of	ADP
fnp-3806	62	13	sad	sad	ADJ
fnp-3806	62	14	to	to	ADP
fnp-3806	62	15	a	a	DET
fnp-3806	62	16	few	few	ADJ
fnp-3806	62	17	triggering	trigger	VERB
fnp-3806	62	18	molecules	molecule	NOUN
fnp-3806	62	19	,	,	PUNCT
fnp-3806	62	20	without	without	ADP
fnp-3806	62	21	considering	consider	VERB
fnp-3806	62	22	the	the	DET
fnp-3806	62	23	wide	wide	ADJ
fnp-3806	62	24	number	number	NOUN
fnp-3806	62	25	of	of	ADP
fnp-3806	62	26	alterations	alteration	NOUN
fnp-3806	62	27	that	that	PRON
fnp-3806	62	28	converge	converge	VERB
fnp-3806	62	29	in	in	ADP
fnp-3806	62	30	the	the	DET
fnp-3806	62	31	pathogenesis	pathogenesis	NOUN
fnp-3806	62	32	of	of	ADP
fnp-3806	62	33	aging	aging	NOUN
fnp-3806	62	34	and	and	CCONJ
fnp-3806	62	35	sad	sad	ADJ
fnp-3806	62	36	.	.	PUNCT
fnp-3806	63	1	recognized	recognize	VERB
fnp-3806	63	2	genetic	genetic	ADJ
fnp-3806	63	3	risk	risk	NOUN
fnp-3806	63	4	factors	factor	NOUN
fnp-3806	63	5	covering	cover	VERB
fnp-3806	63	6	multiple	multiple	ADJ
fnp-3806	63	7	molecular	molecular	ADJ
fnp-3806	63	8	signals	signal	NOUN
fnp-3806	63	9	are	be	AUX
fnp-3806	63	10	increasing	increase	VERB
fnp-3806	63	11	in	in	ADP
fnp-3806	63	12	number	number	NOUN
fnp-3806	63	13	.	.	PUNCT
fnp-3806	64	1	molecular	molecular	ADJ
fnp-3806	64	2	alterations	alteration	NOUN
fnp-3806	64	3	of	of	ADP
fnp-3806	64	4	lipid	lipid	ADJ
fnp-3806	64	5	rafts	raft	NOUN
fnp-3806	64	6	,	,	PUNCT
fnp-3806	64	7	protein	protein	NOUN
fnp-3806	64	8	synthesis	synthesis	NOUN
fnp-3806	64	9	from	from	ADP
fnp-3806	64	10	the	the	DET
fnp-3806	64	11	nucleolus	nucleolus	NOUN
fnp-3806	64	12	to	to	ADP
fnp-3806	64	13	the	the	DET
fnp-3806	64	14	ribosome	ribosome	ADJ
fnp-3806	64	15	,	,	PUNCT
fnp-3806	64	16	protein	protein	NOUN
fnp-3806	64	17	phosphorylation	phosphorylation	NOUN
fnp-3806	64	18	,	,	PUNCT
fnp-3806	64	19	kinase	kinase	NOUN
fnp-3806	64	20	activation	activation	NOUN
fnp-3806	64	21	,	,	PUNCT
fnp-3806	64	22	purine	purine	NOUN
fnp-3806	64	23	metabolism	metabolism	NOUN
fnp-3806	64	24	,	,	PUNCT
fnp-3806	64	25	epigenetic	epigenetic	ADJ
fnp-3806	64	26	regulation	regulation	NOUN
fnp-3806	64	27	of	of	ADP
fnp-3806	64	28	dna	dna	PROPN
fnp-3806	64	29	and	and	CCONJ
fnp-3806	64	30	rna	rna	PROPN
fnp-3806	64	31	,	,	PUNCT
fnp-3806	64	32	mitochondria	mitochondria	NOUN
fnp-3806	64	33	and	and	CCONJ
fnp-3806	64	34	energy	energy	NOUN
fnp-3806	64	35	metabolism	metabolism	NOUN
fnp-3806	64	36	,	,	PUNCT
fnp-3806	64	37	inflammation	inflammation	NOUN
fnp-3806	64	38	,	,	PUNCT
fnp-3806	64	39	oxidative	oxidative	ADJ
fnp-3806	64	40	stress	stress	NOUN
fnp-3806	64	41	,	,	PUNCT
fnp-3806	64	42	cell	cell	NOUN
fnp-3806	64	43	-	-	PUNCT
fnp-3806	64	44	cycle	cycle	NOUN
fnp-3806	64	45	re	re	NOUN
fnp-3806	64	46	-	-	NOUN
fnp-3806	64	47	entry	entry	NOUN
fnp-3806	64	48	,	,	PUNCT
fnp-3806	64	49	and	and	CCONJ
fnp-3806	64	50	cell	cell	NOUN
fnp-3806	64	51	death	death	NOUN
fnp-3806	64	52	precede	precede	NOUN
fnp-3806	64	53	,	,	PUNCT
fnp-3806	64	54	in	in	ADP
fnp-3806	64	55	some	some	DET
fnp-3806	64	56	regions	region	NOUN
fnp-3806	64	57	(	(	PUNCT
fnp-3806	64	58	i.e.	i.e.	X
fnp-3806	64	59	,	,	PUNCT
fnp-3806	64	60	frontal	frontal	ADJ
fnp-3806	64	61	cortex	cortex	NOUN
fnp-3806	64	62	)	)	PUNCT
fnp-3806	64	63	,	,	PUNCT
fnp-3806	64	64	abnormal	abnormal	ADJ
fnp-3806	64	65	tau	tau	PROPN
fnp-3806	64	66	deposition	deposition	NOUN
fnp-3806	64	67	and	and	CCONJ
fnp-3806	64	68	amyloid	amyloid	NOUN
fnp-3806	64	69	plaques	plaque	NOUN
fnp-3806	64	70	.	.	PUNCT
fnp-3806	65	1	human	human	ADJ
fnp-3806	65	2	brain	brain	NOUN
fnp-3806	65	3	aging	aging	NOUN
fnp-3806	65	4	and	and	CCONJ
fnp-3806	65	5	sad	sad	ADJ
fnp-3806	65	6	do	do	AUX
fnp-3806	65	7	not	not	PART
fnp-3806	65	8	follow	follow	VERB
fnp-3806	65	9	a	a	DET
fnp-3806	65	10	linear	linear	ADJ
fnp-3806	65	11	logic	logic	NOUN
fnp-3806	65	12	based	base	VERB
fnp-3806	65	13	on	on	ADP
fnp-3806	65	14	the	the	DET
fnp-3806	65	15	assumption	assumption	NOUN
fnp-3806	65	16	that	that	SCONJ
fnp-3806	65	17	a	a	DET
fnp-3806	65	18	cause	cause	NOUN
fnp-3806	65	19	results	result	NOUN
fnp-3806	65	20	in	in	ADP
fnp-3806	65	21	one	one	NUM
fnp-3806	65	22	or	or	CCONJ
fnp-3806	65	23	several	several	ADJ
fnp-3806	65	24	effects	effect	NOUN
fnp-3806	65	25	;	;	PUNCT
fnp-3806	65	26	several	several	ADJ
fnp-3806	65	27	separate	separate	ADJ
fnp-3806	65	28	alterations	alteration	NOUN
fnp-3806	65	29	converge	converge	VERB
fnp-3806	65	30	and	and	CCONJ
fnp-3806	65	31	potentiate	potentiate	VERB
fnp-3806	65	32	each	each	DET
fnp-3806	65	33	other	other	ADJ
fnp-3806	65	34	to	to	PART
fnp-3806	65	35	incorporate	incorporate	VERB
fnp-3806	65	36	anomalies	anomaly	NOUN
fnp-3806	65	37	in	in	ADP
fnp-3806	65	38	additional	additional	ADJ
fnp-3806	65	39	pathways	pathway	NOUN
fnp-3806	65	40	.	.	PUNCT
fnp-3806	66	1	tau	tau	PROPN
fnp-3806	66	2	seeding	seed	VERB
fnp-3806	66	3	and	and	CCONJ
fnp-3806	66	4	spreading	spread	VERB
fnp-3806	66	5	are	be	AUX
fnp-3806	66	6	active	active	ADJ
fnp-3806	66	7	intercellular	intercellular	ADJ
fnp-3806	66	8	and	and	CCONJ
fnp-3806	66	9	intracellular	intracellular	ADJ
fnp-3806	66	10	processes	process	NOUN
fnp-3806	66	11	that	that	PRON
fnp-3806	66	12	explain	explain	VERB
fnp-3806	66	13	,	,	PUNCT
fnp-3806	66	14	only	only	ADV
fnp-3806	66	15	in	in	ADP
fnp-3806	66	16	part	part	NOUN
fnp-3806	66	17	,	,	PUNCT
fnp-3806	66	18	disease	disease	NOUN
fnp-3806	66	19	progression	progression	NOUN
fnp-3806	66	20	.	.	PUNCT
fnp-3806	67	1	cell	cell	NOUN
fnp-3806	67	2	and	and	CCONJ
fnp-3806	67	3	region	region	NOUN
fnp-3806	67	4	vulnerability	vulnerability	NOUN
fnp-3806	67	5	are	be	AUX
fnp-3806	67	6	essential	essential	ADJ
fnp-3806	67	7	elements	element	NOUN
fnp-3806	67	8	.	.	PUNCT
fnp-3806	68	1	brain	brain	NOUN
fnp-3806	68	2	aging	aging	NOUN
fnp-3806	68	3	with	with	ADP
fnp-3806	68	4	neurofibrillary	neurofibrillary	ADJ
fnp-3806	68	5	tangles	tangle	NOUN
fnp-3806	68	6	(	(	PUNCT
fnp-3806	68	7	nfts	nft	NOUN
fnp-3806	68	8	)	)	PUNCT
fnp-3806	68	9	restricted	restrict	VERB
fnp-3806	68	10	to	to	ADP
fnp-3806	68	11	the	the	DET
fnp-3806	68	12	temporal	temporal	ADJ
fnp-3806	68	13	lobe	lobe	NOUN
fnp-3806	68	14	and	and	CCONJ
fnp-3806	68	15	selected	select	VERB
fnp-3806	68	16	nuclei	nucleus	NOUN
fnp-3806	68	17	of	of	ADP
fnp-3806	68	18	the	the	DET
fnp-3806	68	19	brain	brain	NOUN
fnp-3806	68	20	stem	stem	NOUN
fnp-3806	68	21	,	,	PUNCT
fnp-3806	68	22	primary	primary	ADJ
fnp-3806	68	23	age	age	NOUN
fnp-3806	68	24	-	-	PUNCT
fnp-3806	68	25	related	relate	VERB
fnp-3806	68	26	tauopathy	tauopathy	NOUN
fnp-3806	68	27	,	,	PUNCT
fnp-3806	68	28	preclinical	preclinical	ADJ
fnp-3806	68	29	ad	ad	NOUN
fnp-3806	68	30	,	,	PUNCT
fnp-3806	68	31	mild	mild	ADJ
fnp-3806	68	32	cognitive	cognitive	ADJ
fnp-3806	68	33	impairment	impairment	NOUN
fnp-3806	68	34	(	(	PUNCT
fnp-3806	68	35	mci	mci	NOUN
fnp-3806	68	36	)	)	PUNCT
fnp-3806	68	37	of	of	ADP
fnp-3806	68	38	alzheimer	alzheimer	PROPN
fnp-3806	68	39	type	type	NOUN
fnp-3806	68	40	,	,	PUNCT
fnp-3806	68	41	typical	typical	ADJ
fnp-3806	68	42	ad	ad	NOUN
fnp-3806	68	43	,	,	PUNCT
fnp-3806	68	44	rapid	rapid	ADJ
fnp-3806	68	45	progressive	progressive	ADJ
fnp-3806	68	46	ad	ad	NOUN
fnp-3806	68	47	,	,	PUNCT
fnp-3806	68	48	and	and	CCONJ
fnp-3806	68	49	ad	ad	NOUN
fnp-3806	68	50	subtypes	subtype	NOUN
fnp-3806	68	51	,	,	PUNCT
fnp-3806	68	52	are	be	AUX
fnp-3806	68	53	forms	form	NOUN
fnp-3806	68	54	of	of	ADP
fnp-3806	68	55	sad	sad	ADJ
fnp-3806	68	56	modulated	modulate	VERB
fnp-3806	68	57	by	by	ADP
fnp-3806	68	58	individual	individual	ADJ
fnp-3806	68	59	genetic	genetic	ADJ
fnp-3806	68	60	and	and	CCONJ
fnp-3806	68	61	molecular	molecular	ADJ
fnp-3806	68	62	factors	factor	NOUN
fnp-3806	68	63	.	.	PUNCT
fnp-3806	69	1	as	as	ADP
fnp-3806	69	2	in	in	ADP
fnp-3806	69	3	atherosclerosis	atherosclerosis	NOUN
fnp-3806	69	4	,	,	PUNCT
fnp-3806	69	5	the	the	DET
fnp-3806	69	6	progression	progression	NOUN
fnp-3806	69	7	of	of	ADP
fnp-3806	69	8	the	the	DET
fnp-3806	69	9	process	process	NOUN
fnp-3806	69	10	has	have	VERB
fnp-3806	69	11	devastating	devastating	ADJ
fnp-3806	69	12	effects	effect	NOUN
fnp-3806	69	13	in	in	ADP
fnp-3806	69	14	a	a	DET
fnp-3806	69	15	relatively	relatively	ADV
fnp-3806	69	16	low	low	ADJ
fnp-3806	69	17	percentage	percentage	NOUN
fnp-3806	69	18	of	of	ADP
fnp-3806	69	19	human	human	ADJ
fnp-3806	69	20	beings	being	NOUN
fnp-3806	69	21	.	.	PUNCT
fnp-3806	70	1	future	future	ADJ
fnp-3806	70	2	modulation	modulation	NOUN
fnp-3806	70	3	of	of	ADP
fnp-3806	70	4	human	human	ADJ
fnp-3806	70	5	brain	brain	NOUN
fnp-3806	70	6	aging	aging	NOUN
fnp-3806	70	7	and	and	CCONJ
fnp-3806	70	8	sad	sad	ADJ
fnp-3806	70	9	will	will	AUX
fnp-3806	70	10	require	require	VERB
fnp-3806	70	11	the	the	DET
fnp-3806	70	12	combined	combined	ADJ
fnp-3806	70	13	application	application	NOUN
fnp-3806	70	14	of	of	ADP
fnp-3806	70	15	artificial	artificial	ADJ
fnp-3806	70	16	intelligence	intelligence	NOUN
fnp-3806	70	17	,	,	PUNCT
fnp-3806	70	18	brain	brain	NOUN
fnp-3806	70	19	dna	dna	PROPN
fnp-3806	70	20	editing	editing	NOUN
fnp-3806	70	21	,	,	PUNCT
fnp-3806	70	22	external	external	ADJ
fnp-3806	70	23	electrical	electrical	ADJ
fnp-3806	70	24	or	or	CCONJ
fnp-3806	70	25	wave	wave	NOUN
fnp-3806	70	26	-	-	PUNCT
fnp-3806	70	27	based	base	VERB
fnp-3806	70	28	signals	signal	NOUN
fnp-3806	70	29	to	to	PART
fnp-3806	70	30	reduce	reduce	VERB
fnp-3806	70	31	energy	energy	NOUN
fnp-3806	70	32	consumption	consumption	NOUN
fnp-3806	70	33	,	,	PUNCT
fnp-3806	70	34	and	and	CCONJ
fnp-3806	70	35	optimization	optimization	NOUN
fnp-3806	70	36	of	of	ADP
fnp-3806	70	37	mitochondrial	mitochondrial	ADJ
fnp-3806	70	38	function	function	NOUN
fnp-3806	70	39	,	,	PUNCT
fnp-3806	70	40	together	together	ADV
fnp-3806	70	41	with	with	ADP
fnp-3806	70	42	implantation	implantation	NOUN
fnp-3806	70	43	of	of	ADP
fnp-3806	70	44	microdevices	microdevice	NOUN
fnp-3806	70	45	,	,	PUNCT
fnp-3806	70	46	to	to	PART
fnp-3806	70	47	facilitate	facilitate	VERB
fnp-3806	70	48	cooperative	cooperative	ADJ
fnp-3806	70	49	human	human	ADJ
fnp-3806	70	50	-	-	PUNCT
fnp-3806	70	51	machine	machine	NOUN
fnp-3806	70	52	operation	operation	NOUN
fnp-3806	70	53	,	,	PUNCT
fnp-3806	70	54	pharmacological	pharmacological	ADJ
fnp-3806	70	55	protection	protection	NOUN
fnp-3806	70	56	of	of	ADP
fnp-3806	70	57	lipid	lipid	NOUN
fnp-3806	70	58	-	-	PUNCT
fnp-3806	70	59	protein	protein	NOUN
fnp-3806	70	60	interactions	interaction	NOUN
fnp-3806	70	61	,	,	PUNCT
fnp-3806	70	62	high	high	ADJ
fnp-3806	70	63	-	-	PUNCT
fnp-3806	70	64	throughput	throughput	NOUN
fnp-3806	70	65	molecular	molecular	ADJ
fnp-3806	70	66	technology	technology	NOUN
fnp-3806	70	67	,	,	PUNCT
fnp-3806	70	68	and	and	CCONJ
fnp-3806	70	69	resetting	reset	VERB
fnp-3806	70	70	during	during	ADP
fnp-3806	70	71	sleep	sleep	NOUN
fnp-3806	70	72	stages	stage	NOUN
fnp-3806	70	73	.	.	PUNCT
fnp-3806	71	1	1	1	X
fnp-3806	71	2	.	.	X
fnp-3806	71	3	introduction	introduction	NOUN
fnp-3806	71	4	the	the	DET
fnp-3806	71	5	clinical	clinical	ADJ
fnp-3806	71	6	and	and	CCONJ
fnp-3806	71	7	neuropathological	neuropathological	ADJ
fnp-3806	71	8	characteristics	characteristic	NOUN
fnp-3806	71	9	and	and	CCONJ
fnp-3806	71	10	clinical	clinical	ADJ
fnp-3806	71	11	correlates	correlate	NOUN
fnp-3806	71	12	of	of	ADP
fnp-3806	71	13	alzheimer	alzheimer	PROPN
fnp-3806	71	14	disease	disease	NOUN
fnp-3806	71	15	(	(	PUNCT
fnp-3806	71	16	ad	ad	NOUN
fnp-3806	71	17	)	)	PUNCT
fnp-3806	71	18	have	have	AUX
fnp-3806	71	19	been	be	AUX
fnp-3806	71	20	described	describe	VERB
fnp-3806	71	21	in	in	ADP
fnp-3806	71	22	several	several	ADJ
fnp-3806	71	23	recent	recent	ADJ
fnp-3806	71	24	reviews	review	NOUN
fnp-3806	71	25	(	(	PUNCT
fnp-3806	71	26	1	1	NUM
fnp-3806	71	27	-	-	SYM
fnp-3806	71	28	9	9	NUM
fnp-3806	71	29	)	)	PUNCT
fnp-3806	71	30	.	.	PUNCT
fnp-3806	72	1	however	however	ADV
fnp-3806	72	2	,	,	PUNCT
fnp-3806	72	3	the	the	DET
fnp-3806	72	4	study	study	NOUN
fnp-3806	72	5	of	of	ADP
fnp-3806	72	6	ad	ad	NOUN
fnp-3806	72	7	has	have	AUX
fnp-3806	72	8	generated	generate	VERB
fnp-3806	72	9	a	a	DET
fnp-3806	72	10	fascinating	fascinating	ADJ
fnp-3806	72	11	and	and	CCONJ
fnp-3806	72	12	complex	complex	ADJ
fnp-3806	72	13	compendium	compendium	NOUN
fnp-3806	72	14	of	of	ADP
fnp-3806	72	15	theories	theory	NOUN
fnp-3806	72	16	,	,	PUNCT
fnp-3806	72	17	hypotheses	hypothesis	NOUN
fnp-3806	72	18	,	,	PUNCT
fnp-3806	72	19	controversies	controversy	NOUN
fnp-3806	72	20	,	,	PUNCT
fnp-3806	72	21	fashion	fashion	NOUN
fnp-3806	72	22	swings	swing	NOUN
fnp-3806	72	23	,	,	PUNCT
fnp-3806	72	24	and	and	CCONJ
fnp-3806	72	25	passionate	passionate	ADJ
fnp-3806	72	26	clashes	clash	NOUN
fnp-3806	72	27	,	,	PUNCT
fnp-3806	72	28	together	together	ADV
fnp-3806	72	29	with	with	ADP
fnp-3806	72	30	tremendous	tremendous	ADJ
fnp-3806	72	31	efforts	effort	NOUN
fnp-3806	72	32	and	and	CCONJ
fnp-3806	72	33	achievements	achievement	NOUN
fnp-3806	72	34	geared	gear	VERB
fnp-3806	72	35	to	to	PART
fnp-3806	72	36	improve	improve	VERB
fnp-3806	72	37	understanding	understanding	NOUN
fnp-3806	72	38	of	of	ADP
fnp-3806	72	39	the	the	DET
fnp-3806	72	40	pathogenesis	pathogenesis	NOUN
fnp-3806	72	41	and	and	CCONJ
fnp-3806	72	42	treatment	treatment	NOUN
fnp-3806	72	43	of	of	ADP
fnp-3806	72	44	the	the	DET
fnp-3806	72	45	disorder	disorder	NOUN
fnp-3806	72	46	.	.	PUNCT
fnp-3806	73	1	the	the	DET
fnp-3806	73	2	present	present	ADJ
fnp-3806	73	3	paper	paper	NOUN
fnp-3806	73	4	is	be	AUX
fnp-3806	73	5	a	a	DET
fnp-3806	73	6	critical	critical	ADJ
fnp-3806	73	7	review	review	NOUN
fnp-3806	73	8	of	of	ADP
fnp-3806	73	9	brain	brain	NOUN
fnp-3806	73	10	aging	aging	NOUN
fnp-3806	73	11	and	and	CCONJ
fnp-3806	73	12	ad	ad	NOUN
fnp-3806	73	13	that	that	PRON
fnp-3806	73	14	includes	include	VERB
fnp-3806	73	15	molecular	molecular	ADJ
fnp-3806	73	16	abnormalities	abnormality	NOUN
fnp-3806	73	17	and	and	CCONJ
fnp-3806	73	18	early	early	ADJ
fnp-3806	73	19	metabolic	metabolic	NOUN
fnp-3806	73	20	alterations	alteration	NOUN
fnp-3806	73	21	beyond	beyond	ADP
fnp-3806	73	22	β	β	NOUN
fnp-3806	73	23	-	-	NOUN
fnp-3806	73	24	amyloid	amyloid	NOUN
fnp-3806	73	25	and	and	CCONJ
fnp-3806	73	26	tau	tau	PROPN
fnp-3806	73	27	pathology	pathology	NOUN
fnp-3806	73	28	.	.	PUNCT
fnp-3806	74	1	these	these	DET
fnp-3806	74	2	changes	change	NOUN
fnp-3806	74	3	,	,	PUNCT
fnp-3806	74	4	together	together	ADV
fnp-3806	74	5	with	with	ADP
fnp-3806	74	6	genetic	genetic	ADJ
fnp-3806	74	7	factors	factor	NOUN
fnp-3806	74	8	,	,	PUNCT
fnp-3806	74	9	converge	converge	VERB
fnp-3806	74	10	in	in	ADP
fnp-3806	74	11	the	the	DET
fnp-3806	74	12	pathogenesis	pathogenesis	NOUN
fnp-3806	74	13	of	of	ADP
fnp-3806	74	14	ad	ad	NOUN
fnp-3806	74	15	.	.	PUNCT
fnp-3806	75	1	learning	learn	VERB
fnp-3806	75	2	about	about	ADP
fnp-3806	75	3	early	early	ADJ
fnp-3806	75	4	molecular	molecular	ADJ
fnp-3806	75	5	modifications	modification	NOUN
fnp-3806	75	6	preceding	precede	VERB
fnp-3806	75	7	by	by	ADP
fnp-3806	75	8	many	many	ADJ
fnp-3806	75	9	years	year	NOUN
fnp-3806	75	10	the	the	DET
fnp-3806	75	11	appearance	appearance	NOUN
fnp-3806	75	12	of	of	ADP
fnp-3806	75	13	clinical	clinical	ADJ
fnp-3806	75	14	symptoms	symptom	NOUN
fnp-3806	75	15	,	,	PUNCT
fnp-3806	75	16	when	when	SCONJ
fnp-3806	75	17	present	present	ADJ
fnp-3806	75	18	,	,	PUNCT
fnp-3806	75	19	will	will	AUX
fnp-3806	75	20	serve	serve	VERB
fnp-3806	75	21	to	to	PART
fnp-3806	75	22	improve	improve	VERB
fnp-3806	75	23	understanding	understanding	NOUN
fnp-3806	75	24	of	of	ADP
fnp-3806	75	25	brain	brain	NOUN
fnp-3806	75	26	aging	aging	NOUN
fnp-3806	75	27	and	and	CCONJ
fnp-3806	75	28	the	the	DET
fnp-3806	75	29	ad	ad	NOUN
fnp-3806	75	30	continuum	continuum	PROPN
fnp-3806	75	31	.	.	PUNCT
fnp-3806	76	1	figure	figure	NOUN
fnp-3806	76	2	1	1	NUM
fnp-3806	76	3	:	:	PUNCT
fnp-3806	76	4	dystrophic	dystrophic	ADJ
fnp-3806	76	5	neurites	neurite	NOUN
fnp-3806	76	6	of	of	ADP
fnp-3806	76	7	sps	sps	PROPN
fnp-3806	76	8	and	and	CCONJ
fnp-3806	76	9	nfts	nft	NOUN
fnp-3806	76	10	in	in	ADP
fnp-3806	76	11	the	the	DET
fnp-3806	76	12	frontal	frontal	ADJ
fnp-3806	76	13	cortex	cortex	NOUN
fnp-3806	76	14	of	of	ADP
fnp-3806	76	15	a	a	DET
fnp-3806	76	16	76	76	NUM
fnp-3806	76	17	-	-	PUNCT
fnp-3806	76	18	year	year	NOUN
fnp-3806	76	19	-	-	PUNCT
fnp-3806	76	20	old	old	ADJ
fnp-3806	76	21	woman	woman	NOUN
fnp-3806	76	22	with	with	ADP
fnp-3806	76	23	dementia	dementia	NOUN
fnp-3806	76	24	.	.	PUNCT
fnp-3806	77	1	paraffin	paraffin	NOUN
fnp-3806	77	2	section	section	NOUN
fnp-3806	77	3	,	,	PUNCT
fnp-3806	77	4	gros	gros	X
fnp-3806	77	5	-	-	ADJ
fnp-3806	77	6	bielschowsky	bielschowsky	NOUN
fnp-3806	77	7	silver	silver	NOUN
fnp-3806	77	8	method	method	NOUN
fnp-3806	77	9	without	without	ADP
fnp-3806	77	10	counterstaining	counterstaine	VERB
fnp-3806	77	11	,	,	PUNCT
fnp-3806	77	12	black	black	ADJ
fnp-3806	77	13	and	and	CCONJ
fnp-3806	77	14	white	white	ADJ
fnp-3806	77	15	figure	figure	NOUN
fnp-3806	77	16	,	,	PUNCT
fnp-3806	77	17	bar	bar	NOUN
fnp-3806	77	18	=	=	SYM
fnp-3806	77	19	25μm	25μm	NOUN
fnp-3806	77	20	.	.	PUNCT
fnp-3806	78	1	until	until	ADP
fnp-3806	78	2	the	the	DET
fnp-3806	78	3	beginning	beginning	NOUN
fnp-3806	78	4	of	of	ADP
fnp-3806	78	5	the	the	DET
fnp-3806	78	6	last	last	ADJ
fnp-3806	78	7	century	century	NOUN
fnp-3806	78	8	,	,	PUNCT
fnp-3806	78	9	cognitive	cognitive	ADJ
fnp-3806	78	10	impairment	impairment	NOUN
fnp-3806	78	11	and	and	CCONJ
fnp-3806	78	12	dementia	dementia	NOUN
fnp-3806	78	13	were	be	AUX
fnp-3806	78	14	considered	consider	VERB
fnp-3806	78	15	natural	natural	ADJ
fnp-3806	78	16	features	feature	NOUN
fnp-3806	78	17	of	of	ADP
fnp-3806	78	18	old	old	ADJ
fnp-3806	78	19	age	age	NOUN
fnp-3806	78	20	.	.	PUNCT
fnp-3806	79	1	multiple	multiple	ADJ
fnp-3806	79	2	brain	brain	NOUN
fnp-3806	79	3	infarcts	infarct	NOUN
fnp-3806	79	4	were	be	AUX
fnp-3806	79	5	common	common	ADJ
fnp-3806	79	6	in	in	ADP
fnp-3806	79	7	old	old	ADJ
fnp-3806	79	8	people	people	NOUN
fnp-3806	79	9	,	,	PUNCT
fnp-3806	79	10	and	and	CCONJ
fnp-3806	79	11	vascular	vascular	ADJ
fnp-3806	79	12	dementia	dementia	NOUN
fnp-3806	79	13	due	due	ADJ
fnp-3806	79	14	to	to	ADP
fnp-3806	79	15	arteriopathy	arteriopathy	PROPN
fnp-3806	79	16	was	be	AUX
fnp-3806	79	17	thought	think	VERB
fnp-3806	79	18	to	to	PART
fnp-3806	79	19	be	be	AUX
fnp-3806	79	20	the	the	DET
fnp-3806	79	21	main	main	ADJ
fnp-3806	79	22	cause	cause	NOUN
fnp-3806	79	23	of	of	ADP
fnp-3806	79	24	senile	senile	ADJ
fnp-3806	79	25	dementia	dementia	NOUN
fnp-3806	79	26	.	.	PUNCT
fnp-3806	80	1	however	however	ADV
fnp-3806	80	2	,	,	PUNCT
fnp-3806	80	3	microscopic	microscopic	ADJ
fnp-3806	80	4	study	study	NOUN
fnp-3806	80	5	of	of	ADP
fnp-3806	80	6	post	post	ADJ
fnp-3806	80	7	-	-	ADJ
fnp-3806	80	8	mortem	mortem	ADJ
fnp-3806	80	9	brains	brain	NOUN
fnp-3806	80	10	stained	stain	VERB
fnp-3806	80	11	with	with	ADP
fnp-3806	80	12	the	the	DET
fnp-3806	80	13	dyes	dye	NOUN
fnp-3806	80	14	available	available	ADJ
fnp-3806	80	15	at	at	ADP
fnp-3806	80	16	that	that	DET
fnp-3806	80	17	time	time	NOUN
fnp-3806	80	18	revealed	reveal	VERB
fnp-3806	80	19	the	the	DET
fnp-3806	80	20	presence	presence	NOUN
fnp-3806	80	21	of	of	ADP
fnp-3806	80	22	certain	certain	ADJ
fnp-3806	80	23	structural	structural	ADJ
fnp-3806	80	24	anomalies	anomaly	NOUN
fnp-3806	80	25	in	in	ADP
fnp-3806	80	26	aged	aged	ADJ
fnp-3806	80	27	individuals	individual	NOUN
fnp-3806	80	28	.	.	PUNCT
fnp-3806	81	1	paul	paul	PROPN
fnp-3806	81	2	block	block	PROPN
fnp-3806	81	3	and	and	CCONJ
fnp-3806	81	4	georges	georges	PROPN
fnp-3806	81	5	marinesco	marinesco	PROPN
fnp-3806	81	6	(	(	PUNCT
fnp-3806	81	7	10	10	NUM
fnp-3806	81	8	)	)	PUNCT
fnp-3806	81	9	described	describe	VERB
fnp-3806	81	10	“	"	PUNCT
fnp-3806	81	11	amas	amas	PROPN
fnp-3806	81	12	ronds	rond	NOUN
fnp-3806	81	13	”	"	PUNCT
fnp-3806	81	14	,	,	PUNCT
fnp-3806	81	15	and	and	CCONJ
fnp-3806	81	16	emil	emil	PROPN
fnp-3806	81	17	redlich	redlich	PROPN
fnp-3806	81	18	(	(	PUNCT
fnp-3806	81	19	11	11	NUM
fnp-3806	81	20	)	)	PUNCT
fnp-3806	81	21	“	"	PUNCT
fnp-3806	81	22	miliare	miliare	NOUN
fnp-3806	81	23	sklerose	sklerose	ADJ
fnp-3806	81	24	”	"	PUNCT
fnp-3806	81	25	in	in	ADP
fnp-3806	81	26	the	the	DET
fnp-3806	81	27	neuropil	neuropil	NOUN
fnp-3806	81	28	,	,	PUNCT
fnp-3806	81	29	interpreted	interpret	VERB
fnp-3806	81	30	at	at	ADP
fnp-3806	81	31	that	that	DET
fnp-3806	81	32	time	time	NOUN
fnp-3806	81	33	as	as	ADP
fnp-3806	81	34	nodules	nodule	NOUN
fnp-3806	81	35	of	of	ADP
fnp-3806	81	36	glial	glial	ADJ
fnp-3806	81	37	sclerosis	sclerosis	NOUN
fnp-3806	81	38	,	,	PUNCT
fnp-3806	81	39	which	which	PRON
fnp-3806	81	40	we	we	PRON
fnp-3806	81	41	now	now	ADV
fnp-3806	81	42	know	know	VERB
fnp-3806	81	43	as	as	ADP
fnp-3806	81	44	senile	senile	ADJ
fnp-3806	81	45	plaques	plaque	NOUN
fnp-3806	81	46	(	(	PUNCT
fnp-3806	81	47	sps	sps	PROPN
fnp-3806	81	48	)	)	PUNCT
fnp-3806	81	49	.	.	PUNCT
fnp-3806	82	1	the	the	DET
fnp-3806	82	2	introduction	introduction	NOUN
fnp-3806	82	3	of	of	ADP
fnp-3806	82	4	the	the	DET
fnp-3806	82	5	max	max	PROPN
fnp-3806	82	6	bielschowsky	bielschowsky	PROPN
fnp-3806	82	7	silver	silver	NOUN
fnp-3806	82	8	method	method	NOUN
fnp-3806	82	9	allowed	allow	VERB
fnp-3806	82	10	visualisation	visualisation	NOUN
fnp-3806	82	11	of	of	ADP
fnp-3806	82	12	argyrophilic	argyrophilic	ADJ
fnp-3806	82	13	structures	structure	NOUN
fnp-3806	82	14	in	in	ADP
fnp-3806	82	15	neurons	neuron	NOUN
fnp-3806	82	16	.	.	PUNCT
fnp-3806	83	1	using	use	VERB
fnp-3806	83	2	this	this	DET
fnp-3806	83	3	method	method	NOUN
fnp-3806	83	4	,	,	PUNCT
fnp-3806	83	5	alois	alois	PROPN
fnp-3806	83	6	alzheimer	alzheimer	PROPN
fnp-3806	83	7	described	describe	VERB
fnp-3806	83	8	for	for	ADP
fnp-3806	83	9	the	the	DET
fnp-3806	83	10	first	first	ADJ
fnp-3806	83	11	time	time	NOUN
fnp-3806	83	12	large	large	ADJ
fnp-3806	83	13	numbers	number	NOUN
fnp-3806	83	14	of	of	ADP
fnp-3806	83	15	argyrophilic	argyrophilic	ADJ
fnp-3806	83	16	neurofibrillary	neurofibrillary	ADJ
fnp-3806	83	17	tangles	tangle	NOUN
fnp-3806	83	18	(	(	PUNCT
fnp-3806	83	19	nfts	nft	NOUN
fnp-3806	83	20	)	)	PUNCT
fnp-3806	83	21	and	and	CCONJ
fnp-3806	83	22	aggregates	aggregate	NOUN
fnp-3806	83	23	of	of	ADP
fnp-3806	83	24	dystrophic	dystrophic	ADJ
fnp-3806	83	25	neurites	neurite	NOUN
fnp-3806	83	26	in	in	ADP
fnp-3806	83	27	the	the	DET
fnp-3806	83	28	brain	brain	NOUN
fnp-3806	83	29	of	of	ADP
fnp-3806	83	30	a	a	DET
fnp-3806	83	31	51	51	NUM
fnp-3806	83	32	-	-	PUNCT
fnp-3806	83	33	year	year	NOUN
fnp-3806	83	34	-	-	PUNCT
fnp-3806	83	35	old	old	ADJ
fnp-3806	83	36	woman	woman	NOUN
fnp-3806	83	37	who	who	PRON
fnp-3806	83	38	had	have	AUX
fnp-3806	83	39	suffered	suffer	VERB
fnp-3806	83	40	from	from	ADP
fnp-3806	83	41	progressive	progressive	ADJ
fnp-3806	83	42	dementia	dementia	NOUN
fnp-3806	83	43	and	and	CCONJ
fnp-3806	83	44	hallucinations	hallucination	NOUN
fnp-3806	83	45	in	in	ADP
fnp-3806	83	46	the	the	DET
fnp-3806	83	47	previous	previous	ADJ
fnp-3806	83	48	four	four	NUM
fnp-3806	83	49	and	and	CCONJ
fnp-3806	83	50	half	half	NOUN
fnp-3806	83	51	years	year	NOUN
fnp-3806	83	52	(	(	PUNCT
fnp-3806	83	53	12	12	NUM
fnp-3806	83	54	)	)	PUNCT
fnp-3806	83	55	.	.	PUNCT
fnp-3806	84	1	other	other	ADJ
fnp-3806	84	2	cases	case	NOUN
fnp-3806	84	3	were	be	AUX
fnp-3806	84	4	published	publish	VERB
fnp-3806	84	5	shortly	shortly	ADV
fnp-3806	84	6	afterwards	afterwards	ADV
fnp-3806	84	7	(	(	PUNCT
fnp-3806	84	8	13	13	NUM
fnp-3806	84	9	)	)	PUNCT
fnp-3806	84	10	.	.	PUNCT
fnp-3806	85	1	the	the	DET
fnp-3806	85	2	term	term	NOUN
fnp-3806	85	3	alzheimer	alzheimer	PROPN
fnp-3806	85	4	’s	’s	PART
fnp-3806	85	5	pre	pre	ADJ
fnp-3806	85	6	-	-	ADJ
fnp-3806	85	7	senile	senile	ADJ
fnp-3806	85	8	dementia	dementia	NOUN
fnp-3806	85	9	was	be	AUX
fnp-3806	85	10	introduced	introduce	VERB
fnp-3806	85	11	by	by	ADP
fnp-3806	85	12	emil	emil	PROPN
fnp-3806	85	13	kraepelin	kraepelin	PROPN
fnp-3806	85	14	(	(	PUNCT
fnp-3806	85	15	14	14	NUM
fnp-3806	85	16	)	)	PUNCT
fnp-3806	85	17	to	to	PART
fnp-3806	85	18	define	define	VERB
fnp-3806	85	19	the	the	DET
fnp-3806	85	20	combination	combination	NOUN
fnp-3806	85	21	of	of	ADP
fnp-3806	85	22	pre	pre	ADJ
fnp-3806	85	23	-	-	ADJ
fnp-3806	85	24	senile	senile	ADJ
fnp-3806	85	25	(	(	PUNCT
fnp-3806	85	26	before	before	ADP
fnp-3806	85	27	the	the	DET
fnp-3806	85	28	age	age	NOUN
fnp-3806	85	29	of	of	ADP
fnp-3806	85	30	65	65	NUM
fnp-3806	85	31	)	)	PUNCT
fnp-3806	85	32	dementia	dementia	NOUN
fnp-3806	85	33	in	in	ADP
fnp-3806	85	34	individuals	individual	NOUN
fnp-3806	85	35	with	with	ADP
fnp-3806	85	36	the	the	DET
fnp-3806	85	37	morphological	morphological	ADJ
fnp-3806	85	38	lesions	lesion	NOUN
fnp-3806	85	39	described	describe	VERB
fnp-3806	85	40	by	by	ADP
fnp-3806	85	41	alzheimer	alzheimer	PROPN
fnp-3806	85	42	.	.	PUNCT
fnp-3806	86	1	oskar	oskar	PROPN
fnp-3806	86	2	fischer	fischer	PROPN
fnp-3806	86	3	(	(	PUNCT
fnp-3806	86	4	15	15	NUM
fnp-3806	86	5	)	)	PUNCT
fnp-3806	86	6	,	,	PUNCT
fnp-3806	86	7	using	use	VERB
fnp-3806	86	8	the	the	DET
fnp-3806	86	9	same	same	ADJ
fnp-3806	86	10	method	method	NOUN
fnp-3806	86	11	,	,	PUNCT
fnp-3806	86	12	described	describe	VERB
fnp-3806	86	13	the	the	DET
fnp-3806	86	14	presence	presence	NOUN
fnp-3806	86	15	of	of	ADP
fnp-3806	86	16	‘	'	PUNCT
fnp-3806	86	17	drusen	drusen	NOUN
fnp-3806	86	18	’	'	PUNCT
fnp-3806	86	19	or	or	CCONJ
fnp-3806	86	20	‘	'	PUNCT
fnp-3806	86	21	drusige	drusige	ADJ
fnp-3806	86	22	nekrosen	nekrosen	NOUN
fnp-3806	86	23	’	'	PUNCT
fnp-3806	86	24	in	in	ADP
fnp-3806	86	25	16	16	NUM
fnp-3806	86	26	cases	case	NOUN
fnp-3806	86	27	of	of	ADP
fnp-3806	86	28	senile	senile	ADJ
fnp-3806	86	29	dementia	dementia	NOUN
fnp-3806	86	30	characterized	characterize	VERB
fnp-3806	86	31	by	by	ADP
fnp-3806	86	32	loss	loss	NOUN
fnp-3806	86	33	of	of	ADP
fnp-3806	86	34	memory	memory	NOUN
fnp-3806	86	35	and	and	CCONJ
fnp-3806	86	36	sense	sense	NOUN
fnp-3806	86	37	of	of	ADP
fnp-3806	86	38	location	location	NOUN
fnp-3806	86	39	,	,	PUNCT
fnp-3806	86	40	disorientation	disorientation	NOUN
fnp-3806	86	41	,	,	PUNCT
fnp-3806	86	42	and	and	CCONJ
fnp-3806	86	43	confabulation	confabulation	NOUN
fnp-3806	86	44	.	.	PUNCT
fnp-3806	87	1	subsequent	subsequent	ADJ
fnp-3806	87	2	fischer	fischer	PROPN
fnp-3806	87	3	reports	report	NOUN
fnp-3806	87	4	(	(	PUNCT
fnp-3806	87	5	16	16	NUM
fnp-3806	87	6	,	,	PUNCT
fnp-3806	87	7	17	17	NUM
fnp-3806	87	8	)	)	PUNCT
fnp-3806	87	9	detailed	detail	VERB
fnp-3806	87	10	the	the	DET
fnp-3806	87	11	morphology	morphology	NOUN
fnp-3806	87	12	of	of	ADP
fnp-3806	87	13	abnormal	abnormal	ADJ
fnp-3806	87	14	fibrils	fibril	NOUN
fnp-3806	87	15	and	and	CCONJ
fnp-3806	87	16	abnormal	abnormal	ADJ
fnp-3806	87	17	neurites	neurite	NOUN
fnp-3806	87	18	,	,	PUNCT
fnp-3806	87	19	and	and	CCONJ
fnp-3806	87	20	their	their	PRON
fnp-3806	87	21	stages	stage	NOUN
fnp-3806	87	22	of	of	ADP
fnp-3806	87	23	formation	formation	NOUN
fnp-3806	87	24	,	,	PUNCT
fnp-3806	87	25	in	in	ADP
fnp-3806	87	26	a	a	DET
fnp-3806	87	27	large	large	ADJ
fnp-3806	87	28	series	series	NOUN
fnp-3806	87	29	of	of	ADP
fnp-3806	87	30	older	old	ADJ
fnp-3806	87	31	individuals	individual	NOUN
fnp-3806	87	32	.	.	PUNCT
fnp-3806	88	1	the	the	DET
fnp-3806	88	2	term	term	NOUN
fnp-3806	88	3	‘	'	PUNCT
fnp-3806	88	4	‘	'	PUNCT
fnp-3806	88	5	senile	senile	ADJ
fnp-3806	88	6	plaque	plaque	NOUN
fnp-3806	88	7	’’	’'	PUNCT
fnp-3806	88	8	(	(	PUNCT
fnp-3806	88	9	sp	sp	NOUN
fnp-3806	88	10	)	)	PUNCT
fnp-3806	88	11	for	for	ADP
fnp-3806	88	12	these	these	DET
fnp-3806	88	13	structures	structure	NOUN
fnp-3806	88	14	was	be	AUX
fnp-3806	88	15	proposed	propose	VERB
fnp-3806	88	16	by	by	ADP
fnp-3806	88	17	simchowitz	simchowitz	NOUN
fnp-3806	88	18	(	(	PUNCT
fnp-3806	88	19	18	18	NUM
fnp-3806	88	20	)	)	PUNCT
fnp-3806	88	21	.	.	PUNCT
fnp-3806	89	1	fischer	fischer	PROPN
fnp-3806	89	2	also	also	ADV
fnp-3806	89	3	described	describe	VERB
fnp-3806	89	4	“	"	PUNCT
fnp-3806	89	5	drusige	drusige	PROPN
fnp-3806	89	6	entartung	entartung	PROPN
fnp-3806	89	7	der	der	PROPN
fnp-3806	89	8	gefässe	gefässe	NOUN
fnp-3806	89	9	”	"	PUNCT
fnp-3806	89	10	which	which	PRON
fnp-3806	89	11	corresponds	correspond	VERB
fnp-3806	89	12	to	to	ADP
fnp-3806	89	13	amyloid	amyloid	VERB
fnp-3806	89	14	angiopathy	angiopathy	ADJ
fnp-3806	89	15	.	.	PUNCT
fnp-3806	90	1	interestingly	interestingly	ADV
fnp-3806	90	2	,	,	PUNCT
fnp-3806	90	3	fischer	fischer	PROPN
fnp-3806	90	4	also	also	ADV
fnp-3806	90	5	reported	report	VERB
fnp-3806	90	6	and	and	CCONJ
fnp-3806	90	7	illustrated	illustrate	VERB
fnp-3806	90	8	the	the	DET
fnp-3806	90	9	presence	presence	NOUN
fnp-3806	90	10	of	of	ADP
fnp-3806	90	11	nfts	nft	NOUN
fnp-3806	90	12	in	in	ADP
fnp-3806	90	13	the	the	DET
fnp-3806	90	14	same	same	ADJ
fnp-3806	90	15	cases	case	NOUN
fnp-3806	90	16	with	with	ADP
fnp-3806	90	17	dementia	dementia	NOUN
fnp-3806	90	18	(	(	PUNCT
fnp-3806	90	19	19	19	NUM
fnp-3806	90	20	)	)	PUNCT
fnp-3806	90	21	.	.	PUNCT
fnp-3806	91	1	hundreds	hundred	NOUN
fnp-3806	91	2	of	of	ADP
fnp-3806	91	3	articles	article	NOUN
fnp-3806	91	4	appeared	appear	VERB
fnp-3806	91	5	in	in	ADP
fnp-3806	91	6	the	the	DET
fnp-3806	91	7	succeeding	succeed	VERB
fnp-3806	91	8	years	year	NOUN
fnp-3806	91	9	.	.	PUNCT
fnp-3806	92	1	alzheimer	alzheimer	PROPN
fnp-3806	92	2	focused	focus	VERB
fnp-3806	92	3	on	on	ADP
fnp-3806	92	4	nfts	nft	NOUN
fnp-3806	92	5	as	as	ADP
fnp-3806	92	6	the	the	DET
fnp-3806	92	7	main	main	ADJ
fnp-3806	92	8	cause	cause	NOUN
fnp-3806	92	9	of	of	ADP
fnp-3806	92	10	dementia	dementia	NOUN
fnp-3806	92	11	,	,	PUNCT
fnp-3806	92	12	whereas	whereas	SCONJ
fnp-3806	92	13	fischer	fischer	PROPN
fnp-3806	92	14	thought	think	VERB
fnp-3806	92	15	that	that	SCONJ
fnp-3806	92	16	sps	sps	PROPN
fnp-3806	92	17	were	be	AUX
fnp-3806	92	18	the	the	DET
fnp-3806	92	19	main	main	ADJ
fnp-3806	92	20	substrate	substrate	NOUN
fnp-3806	92	21	of	of	ADP
fnp-3806	92	22	dementia	dementia	NOUN
fnp-3806	92	23	in	in	ADP
fnp-3806	92	24	older	old	ADJ
fnp-3806	92	25	cases	case	NOUN
fnp-3806	92	26	.	.	PUNCT
fnp-3806	93	1	moreover	moreover	ADV
fnp-3806	93	2	,	,	PUNCT
fnp-3806	93	3	alzheimer	alzheimer	PROPN
fnp-3806	93	4	contemplated	contemplate	VERB
fnp-3806	93	5	nfts	nft	NOUN
fnp-3806	93	6	as	as	ADP
fnp-3806	93	7	aggregates	aggregate	NOUN
fnp-3806	93	8	of	of	ADP
fnp-3806	93	9	abnormal	abnormal	ADJ
fnp-3806	93	10	neurofibrils	neurofibril	NOUN
fnp-3806	93	11	,	,	PUNCT
fnp-3806	93	12	while	while	SCONJ
fnp-3806	93	13	fischer	fischer	PROPN
fnp-3806	93	14	considered	consider	VERB
fnp-3806	93	15	dystrophic	dystrophic	ADJ
fnp-3806	93	16	neurites	neurite	NOUN
fnp-3806	93	17	of	of	ADP
fnp-3806	93	18	sps	sps	PROPN
fnp-3806	93	19	composed	compose	VERB
fnp-3806	93	20	of	of	ADP
fnp-3806	93	21	abnormal	abnormal	ADJ
fnp-3806	93	22	neurofibrils	neurofibril	NOUN
fnp-3806	93	23	,	,	PUNCT
fnp-3806	93	24	and	and	CCONJ
fnp-3806	93	25	nfts	nft	VERB
fnp-3806	93	26	a	a	DET
fnp-3806	93	27	particular	particular	ADJ
fnp-3806	93	28	abnormality	abnormality	NOUN
fnp-3806	93	29	of	of	ADP
fnp-3806	93	30	nerve	nerve	NOUN
fnp-3806	93	31	cells	cell	NOUN
fnp-3806	93	32	(	(	PUNCT
fnp-3806	93	33	19	19	NUM
fnp-3806	93	34	)	)	PUNCT
fnp-3806	93	35	.	.	PUNCT
fnp-3806	94	1	bielschowsky	bielschowsky	PROPN
fnp-3806	94	2	proposed	propose	VERB
fnp-3806	94	3	a	a	DET
fnp-3806	94	4	link	link	NOUN
fnp-3806	94	5	between	between	ADP
fnp-3806	94	6	tangles	tangle	NOUN
fnp-3806	94	7	and	and	CCONJ
fnp-3806	94	8	neuritic	neuritic	ADJ
fnp-3806	94	9	changes	change	NOUN
fnp-3806	94	10	(	(	PUNCT
fnp-3806	94	11	20	20	NUM
fnp-3806	94	12	)	)	PUNCT
fnp-3806	94	13	(	(	PUNCT
fnp-3806	94	14	figures	figure	NOUN
fnp-3806	94	15	1	1	NUM
fnp-3806	94	16	and	and	CCONJ
fnp-3806	94	17	2	2	NUM
fnp-3806	94	18	)	)	PUNCT
fnp-3806	94	19	.	.	PUNCT
fnp-3806	95	1	nfts	nft	NOUN
fnp-3806	95	2	and	and	CCONJ
fnp-3806	95	3	sps	sps	NOUN
fnp-3806	95	4	are	be	AUX
fnp-3806	95	5	now	now	ADV
fnp-3806	95	6	considered	consider	VERB
fnp-3806	95	7	ad	ad	NOUN
fnp-3806	95	8	-	-	PUNCT
fnp-3806	95	9	related	relate	VERB
fnp-3806	95	10	pathology	pathology	NOUN
fnp-3806	95	11	or	or	CCONJ
fnp-3806	95	12	ad	ad	NOUN
fnp-3806	95	13	-	-	PUNCT
fnp-3806	95	14	neuropathologic	neuropathologic	NOUN
fnp-3806	95	15	change	change	NOUN
fnp-3806	95	16	(	(	PUNCT
fnp-3806	95	17	adnc	adnc	ADJ
fnp-3806	95	18	)	)	PUNCT
fnp-3806	95	19	(	(	PUNCT
fnp-3806	95	20	https://www.alz.org/media/documents/alzheimers-facts-and-figures.pdf	https://www.alz.org/media/documents/alzheimers-facts-and-figures.pdf	PROPN
fnp-3806	95	21	)	)	PUNCT
fnp-3806	95	22	.	.	PUNCT
fnp-3806	96	1	the	the	DET
fnp-3806	96	2	term	term	NOUN
fnp-3806	96	3	pick	pick	PROPN
fnp-3806	96	4	’s	’s	PART
fnp-3806	96	5	disease	disease	NOUN
fnp-3806	96	6	(	(	PUNCT
fnp-3806	96	7	pid	pid	NOUN
fnp-3806	96	8	)	)	PUNCT
fnp-3806	96	9	was	be	AUX
fnp-3806	96	10	coined	coin	VERB
fnp-3806	96	11	in	in	ADP
fnp-3806	96	12	1926	1926	NUM
fnp-3806	96	13	to	to	PART
fnp-3806	96	14	distinguish	distinguish	VERB
fnp-3806	96	15	ad	ad	NOUN
fnp-3806	96	16	from	from	ADP
fnp-3806	96	17	pid	pid	X
fnp-3806	96	18	primary	primary	ADJ
fnp-3806	96	19	frontotemporal	frontotemporal	ADJ
fnp-3806	96	20	degenerative	degenerative	ADJ
fnp-3806	96	21	atrophy	atrophy	NOUN
fnp-3806	96	22	(	(	PUNCT
fnp-3806	96	23	21	21	NUM
fnp-3806	96	24	)	)	PUNCT
fnp-3806	96	25	.	.	PUNCT
fnp-3806	97	1	as	as	ADV
fnp-3806	97	2	late	late	ADV
fnp-3806	97	3	as	as	ADP
fnp-3806	97	4	the	the	DET
fnp-3806	97	5	1960s	1960	NOUN
fnp-3806	97	6	,	,	PUNCT
fnp-3806	97	7	ad	ad	NOUN
fnp-3806	97	8	and	and	CCONJ
fnp-3806	97	9	pid	pid	NOUN
fnp-3806	97	10	were	be	AUX
fnp-3806	97	11	considered	consider	VERB
fnp-3806	97	12	early	early	ADJ
fnp-3806	97	13	dementias	dementia	NOUN
fnp-3806	97	14	,	,	PUNCT
fnp-3806	97	15	whereas	whereas	SCONJ
fnp-3806	97	16	pure	pure	ADJ
fnp-3806	97	17	senile	senile	ADJ
fnp-3806	97	18	dementia	dementia	NOUN
fnp-3806	97	19	,	,	PUNCT
fnp-3806	97	20	vascular	vascular	ADJ
fnp-3806	97	21	dementias	dementia	NOUN
fnp-3806	97	22	,	,	PUNCT
fnp-3806	97	23	and	and	CCONJ
fnp-3806	97	24	mixed	mixed	ADJ
fnp-3806	97	25	(	(	PUNCT
fnp-3806	97	26	vascular	vascular	ADJ
fnp-3806	97	27	and	and	CCONJ
fnp-3806	97	28	degenerative	degenerative	ADJ
fnp-3806	97	29	)	)	PUNCT
fnp-3806	97	30	were	be	AUX
fnp-3806	97	31	classified	classify	VERB
fnp-3806	97	32	as	as	ADP
fnp-3806	97	33	dementias	dementia	NOUN
fnp-3806	97	34	in	in	ADP
fnp-3806	97	35	old	old	ADJ
fnp-3806	97	36	age	age	NOUN
fnp-3806	97	37	(	(	PUNCT
fnp-3806	97	38	22	22	NUM
fnp-3806	97	39	)	)	PUNCT
fnp-3806	97	40	.	.	PUNCT
fnp-3806	98	1	the	the	DET
fnp-3806	98	2	frontiers	frontier	NOUN
fnp-3806	98	3	between	between	ADP
fnp-3806	98	4	ad	ad	NOUN
fnp-3806	98	5	and	and	CCONJ
fnp-3806	98	6	pure	pure	ADJ
fnp-3806	98	7	senile	senile	ADJ
fnp-3806	98	8	dementia	dementia	NOUN
fnp-3806	98	9	were	be	AUX
fnp-3806	98	10	not	not	PART
fnp-3806	98	11	clear	clear	ADJ
fnp-3806	98	12	,	,	PUNCT
fnp-3806	98	13	as	as	SCONJ
fnp-3806	98	14	the	the	DET
fnp-3806	98	15	onset	onset	NOUN
fnp-3806	98	16	of	of	ADP
fnp-3806	98	17	clinical	clinical	ADJ
fnp-3806	98	18	symptoms	symptom	NOUN
fnp-3806	98	19	in	in	ADP
fnp-3806	98	20	many	many	ADJ
fnp-3806	98	21	cases	case	NOUN
fnp-3806	98	22	classified	classify	VERB
fnp-3806	98	23	as	as	SCONJ
fnp-3806	98	24	ad	ad	NOUN
fnp-3806	98	25	was	be	AUX
fnp-3806	98	26	after	after	ADP
fnp-3806	98	27	the	the	DET
fnp-3806	98	28	age	age	NOUN
fnp-3806	98	29	of	of	ADP
fnp-3806	98	30	sixty	sixty	NUM
fnp-3806	98	31	(	(	PUNCT
fnp-3806	98	32	23	23	NUM
fnp-3806	98	33	)	)	PUNCT
fnp-3806	98	34	.	.	PUNCT
fnp-3806	99	1	it	it	PRON
fnp-3806	99	2	was	be	AUX
fnp-3806	99	3	not	not	PART
fnp-3806	99	4	until	until	ADP
fnp-3806	99	5	the	the	DET
fnp-3806	99	6	1970s	1970	NOUN
fnp-3806	99	7	that	that	SCONJ
fnp-3806	99	8	alzheimer	alzheimer	PROPN
fnp-3806	99	9	’s	’s	PART
fnp-3806	99	10	pre	pre	ADJ
fnp-3806	99	11	-	-	ADJ
fnp-3806	99	12	senile	senile	ADJ
fnp-3806	99	13	dementia	dementia	NOUN
fnp-3806	99	14	and	and	CCONJ
fnp-3806	99	15	senile	senile	ADJ
fnp-3806	99	16	dementia	dementia	NOUN
fnp-3806	99	17	with	with	ADP
fnp-3806	99	18	changes	change	NOUN
fnp-3806	99	19	of	of	ADP
fnp-3806	99	20	alzheimer	alzheimer	NOUN
fnp-3806	99	21	type	type	NOUN
fnp-3806	99	22	were	be	AUX
fnp-3806	99	23	considered	consider	VERB
fnp-3806	99	24	to	to	PART
fnp-3806	99	25	be	be	AUX
fnp-3806	99	26	within	within	ADP
fnp-3806	99	27	the	the	DET
fnp-3806	99	28	same	same	ADJ
fnp-3806	99	29	spectrum	spectrum	NOUN
fnp-3806	99	30	(	(	PUNCT
fnp-3806	99	31	24	24	NUM
fnp-3806	99	32	-	-	SYM
fnp-3806	99	33	27	27	NUM
fnp-3806	99	34	)	)	PUNCT
fnp-3806	99	35	.	.	PUNCT
fnp-3806	100	1	the	the	DET
fnp-3806	100	2	inclusive	inclusive	ADJ
fnp-3806	100	3	term	term	NOUN
fnp-3806	100	4	“	"	PUNCT
fnp-3806	100	5	alzheimer	alzheimer	PROPN
fnp-3806	100	6	-	-	PUNCT
fnp-3806	100	7	fischer	fischer	PROPN
fnp-3806	100	8	dementia	dementia	NOUN
fnp-3806	100	9	”	"	PUNCT
fnp-3806	100	10	was	be	AUX
fnp-3806	100	11	never	never	ADV
fnp-3806	100	12	contemplated	contemplate	VERB
fnp-3806	100	13	.	.	PUNCT
fnp-3806	101	1	figure	figure	NOUN
fnp-3806	101	2	2	2	NUM
fnp-3806	101	3	:	:	PUNCT
fnp-3806	101	4	neurofibrillary	neurofibrillary	ADJ
fnp-3806	101	5	tangles	tangle	NOUN
fnp-3806	101	6	in	in	ADP
fnp-3806	101	7	the	the	DET
fnp-3806	101	8	ca1	ca1	PROPN
fnp-3806	101	9	region	region	NOUN
fnp-3806	101	10	of	of	ADP
fnp-3806	101	11	the	the	DET
fnp-3806	101	12	hippocampus	hippocampus	NOUN
fnp-3806	101	13	of	of	ADP
fnp-3806	101	14	a	a	DET
fnp-3806	101	15	man	man	NOUN
fnp-3806	101	16	aged	age	VERB
fnp-3806	101	17	69	69	NUM
fnp-3806	101	18	years	year	NOUN
fnp-3806	101	19	with	with	ADP
fnp-3806	101	20	no	no	DET
fnp-3806	101	21	apparent	apparent	ADJ
fnp-3806	101	22	cognitive	cognitive	ADJ
fnp-3806	101	23	impairment	impairment	NOUN
fnp-3806	101	24	.	.	PUNCT
fnp-3806	102	1	paraffin	paraffin	NOUN
fnp-3806	102	2	section	section	NOUN
fnp-3806	102	3	,	,	PUNCT
fnp-3806	102	4	gallyas	gallyas	NOUN
fnp-3806	102	5	staining	staining	NOUN
fnp-3806	102	6	,	,	PUNCT
fnp-3806	102	7	lightly	lightly	ADV
fnp-3806	102	8	counterstained	counterstaine	VERB
fnp-3806	102	9	with	with	ADP
fnp-3806	102	10	haemtoxylin	haemtoxylin	NOUN
fnp-3806	102	11	,	,	PUNCT
fnp-3806	102	12	bar	bar	NOUN
fnp-3806	102	13	=	=	SYM
fnp-3806	102	14	25μm	25μm	NOUN
fnp-3806	102	15	.	.	PUNCT
fnp-3806	103	1	the	the	DET
fnp-3806	103	2	first	first	ADJ
fnp-3806	103	3	approach	approach	NOUN
fnp-3806	103	4	toward	toward	ADP
fnp-3806	103	5	a	a	DET
fnp-3806	103	6	clinical	clinical	ADJ
fnp-3806	103	7	consensus	consensus	NOUN
fnp-3806	103	8	on	on	ADP
fnp-3806	103	9	ad	ad	NOUN
fnp-3806	103	10	was	be	AUX
fnp-3806	103	11	made	make	VERB
fnp-3806	103	12	in	in	ADP
fnp-3806	103	13	1984	1984	NUM
fnp-3806	103	14	;	;	PUNCT
fnp-3806	103	15	clinical	clinical	ADJ
fnp-3806	103	16	diagnosis	diagnosis	NOUN
fnp-3806	103	17	of	of	ADP
fnp-3806	103	18	ad	ad	NOUN
fnp-3806	103	19	was	be	AUX
fnp-3806	103	20	set	set	VERB
fnp-3806	103	21	up	up	ADP
fnp-3806	103	22	in	in	ADP
fnp-3806	103	23	three	three	NUM
fnp-3806	103	24	categories	category	NOUN
fnp-3806	103	25	–	–	PUNCT
fnp-3806	103	26	possible	possible	ADJ
fnp-3806	103	27	,	,	PUNCT
fnp-3806	103	28	probable	probable	ADJ
fnp-3806	103	29	,	,	PUNCT
fnp-3806	103	30	and	and	CCONJ
fnp-3806	103	31	definite	definite	NOUN
fnp-3806	103	32	(	(	PUNCT
fnp-3806	103	33	requiring	require	VERB
fnp-3806	103	34	neuropathological	neuropathological	ADJ
fnp-3806	103	35	verification	verification	NOUN
fnp-3806	103	36	)	)	PUNCT
fnp-3806	103	37	(	(	PUNCT
fnp-3806	103	38	28	28	NUM
fnp-3806	103	39	)	)	PUNCT
fnp-3806	103	40	.	.	PUNCT
fnp-3806	104	1	definite	definite	ADJ
fnp-3806	104	2	ad	ad	NOUN
fnp-3806	104	3	was	be	AUX
fnp-3806	104	4	fixed	fix	VERB
fnp-3806	104	5	as	as	ADP
fnp-3806	104	6	a	a	DET
fnp-3806	104	7	neurodegenerative	neurodegenerative	ADJ
fnp-3806	104	8	disease	disease	NOUN
fnp-3806	104	9	manifested	manifest	VERB
fnp-3806	104	10	by	by	ADP
fnp-3806	104	11	progressive	progressive	ADJ
fnp-3806	104	12	dementia	dementia	NOUN
fnp-3806	104	13	with	with	ADP
fnp-3806	104	14	a	a	DET
fnp-3806	104	15	neuropathological	neuropathological	ADJ
fnp-3806	104	16	substrate	substrate	NOUN
fnp-3806	104	17	characterized	characterize	VERB
fnp-3806	104	18	by	by	ADP
fnp-3806	104	19	brain	brain	NOUN
fnp-3806	104	20	atrophy	atrophy	NOUN
fnp-3806	104	21	,	,	PUNCT
fnp-3806	104	22	neuronal	neuronal	ADJ
fnp-3806	104	23	death	death	NOUN
fnp-3806	104	24	,	,	PUNCT
fnp-3806	104	25	and	and	CCONJ
fnp-3806	104	26	a	a	DET
fnp-3806	104	27	particular	particular	ADJ
fnp-3806	104	28	distribution	distribution	NOUN
fnp-3806	104	29	of	of	ADP
fnp-3806	104	30	abundant	abundant	ADJ
fnp-3806	104	31	sps	sps	NOUN
fnp-3806	104	32	and	and	CCONJ
fnp-3806	104	33	nfts	nft	NOUN
fnp-3806	104	34	in	in	ADP
fnp-3806	104	35	the	the	DET
fnp-3806	104	36	brain	brain	NOUN
fnp-3806	104	37	.	.	PUNCT
fnp-3806	105	1	box	box	PROPN
fnp-3806	105	2	1	1	NUM
fnp-3806	105	3	:	:	PUNCT
fnp-3806	105	4	clinical	clinical	ADJ
fnp-3806	105	5	classification	classification	NOUN
fnp-3806	105	6	of	of	ADP
fnp-3806	105	7	alzheimer	alzheimer	PROPN
fnp-3806	105	8	’s	’s	PART
fnp-3806	105	9	disease	disease	NOUN
fnp-3806	105	10	(	(	PUNCT
fnp-3806	105	11	https://www.alz.org/media/documents/alzheimers-facts-and-figures.pdf	https://www.alz.org/media/documents/alzheimers-facts-and-figures.pdf	PROPN
fnp-3806	105	12	)	)	PUNCT
fnp-3806	105	13	.	.	PUNCT
fnp-3806	106	1	preclinical	preclinical	ADJ
fnp-3806	106	2	alzheimer	alzheimer	PROPN
fnp-3806	106	3	’s	’s	PART
fnp-3806	106	4	disease	disease	NOUN
fnp-3806	106	5	in	in	ADP
fnp-3806	106	6	this	this	DET
fnp-3806	106	7	phase	phase	NOUN
fnp-3806	106	8	,	,	PUNCT
fnp-3806	106	9	individuals	individual	NOUN
fnp-3806	106	10	may	may	AUX
fnp-3806	106	11	have	have	VERB
fnp-3806	106	12	measurable	measurable	ADJ
fnp-3806	106	13	brain	brain	NOUN
fnp-3806	106	14	changes	change	NOUN
fnp-3806	106	15	that	that	PRON
fnp-3806	106	16	indicate	indicate	VERB
fnp-3806	106	17	the	the	DET
fnp-3806	106	18	earliest	early	ADJ
fnp-3806	106	19	signs	sign	NOUN
fnp-3806	106	20	of	of	ADP
fnp-3806	106	21	ad	ad	NOUN
fnp-3806	106	22	(	(	PUNCT
fnp-3806	106	23	biomarkers	biomarker	NOUN
fnp-3806	106	24	)	)	PUNCT
fnp-3806	106	25	,	,	PUNCT
fnp-3806	106	26	but	but	CCONJ
fnp-3806	106	27	they	they	PRON
fnp-3806	106	28	have	have	AUX
fnp-3806	106	29	not	not	PART
fnp-3806	106	30	yet	yet	ADV
fnp-3806	106	31	developed	develop	VERB
fnp-3806	106	32	symptoms	symptom	NOUN
fnp-3806	106	33	such	such	ADJ
fnp-3806	106	34	as	as	ADP
fnp-3806	106	35	memory	memory	NOUN
fnp-3806	106	36	loss	loss	NOUN
fnp-3806	106	37	.	.	PUNCT
fnp-3806	107	1	mild	mild	ADJ
fnp-3806	107	2	cognitive	cognitive	ADJ
fnp-3806	107	3	impairment	impairment	NOUN
fnp-3806	107	4	due	due	ADP
fnp-3806	107	5	to	to	ADP
fnp-3806	107	6	alzheimer	alzheimer	PROPN
fnp-3806	107	7	’s	’s	PART
fnp-3806	107	8	disease	disease	NOUN
fnp-3806	107	9	people	people	NOUN
fnp-3806	107	10	with	with	ADP
fnp-3806	107	11	mci	mci	PROPN
fnp-3806	107	12	due	due	ADP
fnp-3806	107	13	to	to	ADP
fnp-3806	107	14	ad	ad	NOUN
fnp-3806	107	15	have	have	AUX
fnp-3806	107	16	biomarker	biomarker	NOUN
fnp-3806	107	17	evidence	evidence	NOUN
fnp-3806	107	18	of	of	ADP
fnp-3806	107	19	alzheimer	alzheimer	PROPN
fnp-3806	107	20	’s	’s	PART
fnp-3806	107	21	brain	brain	NOUN
fnp-3806	107	22	changes	change	NOUN
fnp-3806	107	23	plus	plus	CCONJ
fnp-3806	107	24	new	new	ADJ
fnp-3806	107	25	but	but	CCONJ
fnp-3806	107	26	subtle	subtle	ADJ
fnp-3806	107	27	symptoms	symptom	NOUN
fnp-3806	107	28	such	such	ADJ
fnp-3806	107	29	as	as	ADP
fnp-3806	107	30	problems	problem	NOUN
fnp-3806	107	31	with	with	ADP
fnp-3806	107	32	memory	memory	NOUN
fnp-3806	107	33	,	,	PUNCT
fnp-3806	107	34	language	language	NOUN
fnp-3806	107	35	and	and	CCONJ
fnp-3806	107	36	thinking	thinking	NOUN
fnp-3806	107	37	.	.	PUNCT
fnp-3806	108	1	these	these	DET
fnp-3806	108	2	cognitive	cognitive	ADJ
fnp-3806	108	3	problems	problem	NOUN
fnp-3806	108	4	may	may	AUX
fnp-3806	108	5	be	be	AUX
fnp-3806	108	6	noticeable	noticeable	ADJ
fnp-3806	108	7	to	to	ADP
fnp-3806	108	8	the	the	DET
fnp-3806	108	9	individual	individual	ADJ
fnp-3806	108	10	,	,	PUNCT
fnp-3806	108	11	family	family	NOUN
fnp-3806	108	12	members	member	NOUN
fnp-3806	108	13	and	and	CCONJ
fnp-3806	108	14	friends	friend	NOUN
fnp-3806	108	15	,	,	PUNCT
fnp-3806	108	16	but	but	CCONJ
fnp-3806	108	17	not	not	PART
fnp-3806	108	18	to	to	ADP
fnp-3806	108	19	others	other	NOUN
fnp-3806	108	20	,	,	PUNCT
fnp-3806	108	21	and	and	CCONJ
fnp-3806	108	22	they	they	PRON
fnp-3806	108	23	may	may	AUX
fnp-3806	108	24	not	not	PART
fnp-3806	108	25	interfere	interfere	VERB
fnp-3806	108	26	with	with	ADP
fnp-3806	108	27	individuals	individual	NOUN
fnp-3806	108	28	’	'	PUNCT
fnp-3806	108	29	ability	ability	NOUN
fnp-3806	108	30	to	to	PART
fnp-3806	108	31	carry	carry	VERB
fnp-3806	108	32	out	out	ADP
fnp-3806	108	33	everyday	everyday	ADJ
fnp-3806	108	34	activities	activity	NOUN
fnp-3806	108	35	.	.	PUNCT
fnp-3806	109	1	mild	mild	ADJ
fnp-3806	109	2	alzheimer	alzheimer	PROPN
fnp-3806	109	3	’s	’s	PART
fnp-3806	109	4	dementia	dementia	NOUN
fnp-3806	109	5	in	in	ADP
fnp-3806	109	6	the	the	DET
fnp-3806	109	7	mild	mild	ADJ
fnp-3806	109	8	stage	stage	NOUN
fnp-3806	109	9	of	of	ADP
fnp-3806	109	10	alzheimer	alzheimer	PROPN
fnp-3806	109	11	’s	’s	PART
fnp-3806	109	12	dementia	dementia	NOUN
fnp-3806	109	13	,	,	PUNCT
fnp-3806	109	14	most	most	ADJ
fnp-3806	109	15	people	people	NOUN
fnp-3806	109	16	are	be	AUX
fnp-3806	109	17	able	able	ADJ
fnp-3806	109	18	to	to	PART
fnp-3806	109	19	function	function	VERB
fnp-3806	109	20	independently	independently	ADV
fnp-3806	109	21	in	in	ADP
fnp-3806	109	22	many	many	ADJ
fnp-3806	109	23	areas	area	NOUN
fnp-3806	109	24	but	but	CCONJ
fnp-3806	109	25	are	be	AUX
fnp-3806	109	26	likely	likely	ADJ
fnp-3806	109	27	to	to	PART
fnp-3806	109	28	require	require	VERB
fnp-3806	109	29	assistance	assistance	NOUN
fnp-3806	109	30	with	with	ADP
fnp-3806	109	31	some	some	DET
fnp-3806	109	32	activities	activity	NOUN
fnp-3806	109	33	to	to	PART
fnp-3806	109	34	maximize	maximize	VERB
fnp-3806	109	35	independence	independence	NOUN
fnp-3806	109	36	and	and	CCONJ
fnp-3806	109	37	remain	remain	VERB
fnp-3806	109	38	safe	safe	ADJ
fnp-3806	109	39	.	.	PUNCT
fnp-3806	110	1	handling	handle	VERB
fnp-3806	110	2	money	money	NOUN
fnp-3806	110	3	and	and	CCONJ
fnp-3806	110	4	paying	pay	VERB
fnp-3806	110	5	bills	bill	NOUN
fnp-3806	110	6	may	may	AUX
fnp-3806	110	7	be	be	AUX
fnp-3806	110	8	especially	especially	ADV
fnp-3806	110	9	challenging	challenging	ADJ
fnp-3806	110	10	,	,	PUNCT
fnp-3806	110	11	and	and	CCONJ
fnp-3806	110	12	they	they	PRON
fnp-3806	110	13	may	may	AUX
fnp-3806	110	14	need	need	VERB
fnp-3806	110	15	more	more	ADJ
fnp-3806	110	16	time	time	NOUN
fnp-3806	110	17	to	to	PART
fnp-3806	110	18	complete	complete	VERB
fnp-3806	110	19	common	common	ADJ
fnp-3806	110	20	daily	daily	ADJ
fnp-3806	110	21	tasks	task	NOUN
fnp-3806	110	22	.	.	PUNCT
fnp-3806	111	1	they	they	PRON
fnp-3806	111	2	may	may	AUX
fnp-3806	111	3	still	still	ADV
fnp-3806	111	4	be	be	AUX
fnp-3806	111	5	able	able	ADJ
fnp-3806	111	6	to	to	PART
fnp-3806	111	7	drive	drive	VERB
fnp-3806	111	8	,	,	PUNCT
fnp-3806	111	9	work	work	NOUN
fnp-3806	111	10	and	and	CCONJ
fnp-3806	111	11	participate	participate	VERB
fnp-3806	111	12	in	in	ADP
fnp-3806	111	13	their	their	PRON
fnp-3806	111	14	favorite	favorite	ADJ
fnp-3806	111	15	activities	activity	NOUN
fnp-3806	111	16	.	.	PUNCT
fnp-3806	112	1	moderate	moderate	PROPN
fnp-3806	112	2	alzheimer	alzheimer	PROPN
fnp-3806	112	3	’s	’s	PROPN
fnp-3806	112	4	dementia	dementia	NOUN
fnp-3806	112	5	in	in	ADP
fnp-3806	112	6	the	the	DET
fnp-3806	112	7	moderate	moderate	ADJ
fnp-3806	112	8	stage	stage	NOUN
fnp-3806	112	9	of	of	ADP
fnp-3806	112	10	alzheimer	alzheimer	PROPN
fnp-3806	112	11	’s	’s	PART
fnp-3806	112	12	dementia	dementia	NOUN
fnp-3806	112	13	,	,	PUNCT
fnp-3806	112	14	which	which	PRON
fnp-3806	112	15	is	be	AUX
fnp-3806	112	16	often	often	ADV
fnp-3806	112	17	the	the	DET
fnp-3806	112	18	longest	long	ADJ
fnp-3806	112	19	stage	stage	NOUN
fnp-3806	113	1	,	,	PUNCT
fnp-3806	113	2	individuals	individual	NOUN
fnp-3806	113	3	experience	experience	VERB
fnp-3806	113	4	more	more	ADJ
fnp-3806	113	5	problems	problem	NOUN
fnp-3806	113	6	with	with	ADP
fnp-3806	113	7	memory	memory	NOUN
fnp-3806	113	8	and	and	CCONJ
fnp-3806	113	9	language	language	NOUN
fnp-3806	113	10	,	,	PUNCT
fnp-3806	113	11	are	be	AUX
fnp-3806	113	12	more	more	ADV
fnp-3806	113	13	likely	likely	ADJ
fnp-3806	113	14	to	to	PART
fnp-3806	113	15	become	become	VERB
fnp-3806	113	16	confused	confused	ADJ
fnp-3806	113	17	,	,	PUNCT
fnp-3806	113	18	and	and	CCONJ
fnp-3806	113	19	find	find	VERB
fnp-3806	113	20	it	it	PRON
fnp-3806	113	21	harder	hard	ADJ
fnp-3806	113	22	to	to	PART
fnp-3806	113	23	complete	complete	VERB
fnp-3806	113	24	multistep	multistep	ADJ
fnp-3806	113	25	tasks	task	NOUN
fnp-3806	113	26	such	such	ADJ
fnp-3806	113	27	as	as	ADP
fnp-3806	113	28	bathing	bathe	VERB
fnp-3806	113	29	and	and	CCONJ
fnp-3806	113	30	dressing	dressing	NOUN
fnp-3806	113	31	.	.	PUNCT
fnp-3806	114	1	they	they	PRON
fnp-3806	114	2	may	may	AUX
fnp-3806	114	3	become	become	VERB
fnp-3806	114	4	incontinent	incontinent	ADJ
fnp-3806	114	5	at	at	ADP
fnp-3806	114	6	times	time	NOUN
fnp-3806	114	7	,	,	PUNCT
fnp-3806	114	8	and	and	CCONJ
fnp-3806	114	9	they	they	PRON
fnp-3806	114	10	may	may	AUX
fnp-3806	114	11	start	start	VERB
fnp-3806	114	12	having	have	VERB
fnp-3806	114	13	personality	personality	NOUN
fnp-3806	114	14	and	and	CCONJ
fnp-3806	114	15	behavioral	behavioral	ADJ
fnp-3806	114	16	changes	change	NOUN
fnp-3806	114	17	,	,	PUNCT
fnp-3806	114	18	including	include	VERB
fnp-3806	114	19	suspiciousness	suspiciousness	NOUN
fnp-3806	114	20	and	and	CCONJ
fnp-3806	114	21	agitation	agitation	NOUN
fnp-3806	114	22	.	.	PUNCT
fnp-3806	115	1	they	they	PRON
fnp-3806	115	2	may	may	AUX
fnp-3806	115	3	also	also	ADV
fnp-3806	115	4	begin	begin	VERB
fnp-3806	115	5	to	to	PART
fnp-3806	115	6	have	have	VERB
fnp-3806	115	7	problems	problem	NOUN
fnp-3806	115	8	recognizing	recognize	VERB
fnp-3806	115	9	loved	love	VERB
fnp-3806	115	10	ones	one	NOUN
fnp-3806	115	11	.	.	PUNCT
fnp-3806	116	1	severe	severe	ADJ
fnp-3806	116	2	alzheimer	alzheimer	PROPN
fnp-3806	116	3	’s	’s	PART
fnp-3806	116	4	dementia	dementia	NOUN
fnp-3806	116	5	in	in	ADP
fnp-3806	116	6	the	the	DET
fnp-3806	116	7	severe	severe	ADJ
fnp-3806	116	8	stage	stage	NOUN
fnp-3806	116	9	of	of	ADP
fnp-3806	116	10	alzheimer	alzheimer	PROPN
fnp-3806	116	11	’s	’s	PART
fnp-3806	116	12	dementia	dementia	NOUN
fnp-3806	116	13	,	,	PUNCT
fnp-3806	116	14	individuals	individual	NOUN
fnp-3806	116	15	’	'	PUNCT
fnp-3806	116	16	ability	ability	NOUN
fnp-3806	116	17	to	to	PART
fnp-3806	116	18	communicate	communicate	VERB
fnp-3806	116	19	verbally	verbally	ADV
fnp-3806	116	20	is	be	AUX
fnp-3806	116	21	greatly	greatly	ADV
fnp-3806	116	22	diminished	diminish	VERB
fnp-3806	116	23	,	,	PUNCT
fnp-3806	116	24	and	and	CCONJ
fnp-3806	116	25	they	they	PRON
fnp-3806	116	26	are	be	AUX
fnp-3806	116	27	likely	likely	ADJ
fnp-3806	116	28	to	to	PART
fnp-3806	116	29	require	require	VERB
fnp-3806	116	30	around	around	ADP
fnp-3806	116	31	-	-	PUNCT
fnp-3806	116	32	the	the	DET
fnp-3806	116	33	-	-	PUNCT
fnp-3806	116	34	clock	clock	NOUN
fnp-3806	116	35	care	care	NOUN
fnp-3806	116	36	.	.	PUNCT
fnp-3806	117	1	because	because	SCONJ
fnp-3806	117	2	of	of	ADP
fnp-3806	117	3	damage	damage	NOUN
fnp-3806	117	4	to	to	ADP
fnp-3806	117	5	areas	area	NOUN
fnp-3806	117	6	of	of	ADP
fnp-3806	117	7	the	the	DET
fnp-3806	117	8	brain	brain	NOUN
fnp-3806	117	9	involved	involve	VERB
fnp-3806	117	10	in	in	ADP
fnp-3806	117	11	movement	movement	NOUN
fnp-3806	117	12	,	,	PUNCT
fnp-3806	117	13	individuals	individual	NOUN
fnp-3806	117	14	become	become	VERB
fnp-3806	117	15	bed	bed	NOUN
fnp-3806	117	16	-	-	PUNCT
fnp-3806	117	17	bound	bind	VERB
fnp-3806	117	18	.	.	PUNCT
fnp-3806	118	1	being	be	AUX
fnp-3806	118	2	bed	bed	NOUN
fnp-3806	118	3	-	-	PUNCT
fnp-3806	118	4	bound	bind	VERB
fnp-3806	118	5	makes	make	VERB
fnp-3806	118	6	them	they	PRON
fnp-3806	118	7	vulnerable	vulnerable	ADJ
fnp-3806	118	8	to	to	ADP
fnp-3806	118	9	physical	physical	ADJ
fnp-3806	118	10	complications	complication	NOUN
fnp-3806	118	11	including	include	VERB
fnp-3806	118	12	blood	blood	NOUN
fnp-3806	118	13	clots	clot	NOUN
fnp-3806	118	14	,	,	PUNCT
fnp-3806	118	15	skin	skin	NOUN
fnp-3806	118	16	infections	infection	NOUN
fnp-3806	118	17	and	and	CCONJ
fnp-3806	118	18	sepsis	sepsis	NOUN
fnp-3806	118	19	,	,	PUNCT
fnp-3806	118	20	which	which	PRON
fnp-3806	118	21	triggers	trigger	VERB
fnp-3806	118	22	body	body	NOUN
fnp-3806	118	23	-	-	PUNCT
fnp-3806	118	24	wide	wide	ADJ
fnp-3806	118	25	inflammation	inflammation	NOUN
fnp-3806	118	26	that	that	PRON
fnp-3806	118	27	can	can	AUX
fnp-3806	118	28	result	result	VERB
fnp-3806	118	29	in	in	ADP
fnp-3806	118	30	organ	organ	NOUN
fnp-3806	118	31	failure	failure	NOUN
fnp-3806	118	32	.	.	PUNCT
fnp-3806	119	1	damage	damage	NOUN
fnp-3806	119	2	to	to	ADP
fnp-3806	119	3	areas	area	NOUN
fnp-3806	119	4	of	of	ADP
fnp-3806	119	5	the	the	DET
fnp-3806	119	6	brain	brain	NOUN
fnp-3806	119	7	that	that	PRON
fnp-3806	119	8	control	control	NOUN
fnp-3806	119	9	swallowing	swallow	VERB
fnp-3806	119	10	makes	make	VERB
fnp-3806	119	11	it	it	PRON
fnp-3806	119	12	difficult	difficult	ADJ
fnp-3806	119	13	to	to	PART
fnp-3806	119	14	eat	eat	VERB
fnp-3806	119	15	and	and	CCONJ
fnp-3806	119	16	drink	drink	VERB
fnp-3806	119	17	.	.	PUNCT
fnp-3806	120	1	because	because	SCONJ
fnp-3806	120	2	of	of	ADP
fnp-3806	120	3	this	this	PRON
fnp-3806	120	4	,	,	PUNCT
fnp-3806	120	5	food	food	NOUN
fnp-3806	120	6	particles	particle	NOUN
fnp-3806	120	7	may	may	AUX
fnp-3806	120	8	be	be	AUX
fnp-3806	120	9	deposited	deposit	VERB
fnp-3806	120	10	in	in	ADP
fnp-3806	120	11	the	the	DET
fnp-3806	120	12	lungs	lung	NOUN
fnp-3806	120	13	and	and	CCONJ
fnp-3806	120	14	cause	cause	VERB
fnp-3806	120	15	lung	lung	NOUN
fnp-3806	120	16	infection	infection	NOUN
fnp-3806	120	17	.	.	PUNCT
fnp-3806	121	1	in	in	ADP
fnp-3806	121	2	contrast	contrast	NOUN
fnp-3806	121	3	to	to	ADP
fnp-3806	121	4	ad	ad	NOUN
fnp-3806	121	5	dementia	dementia	NOUN
fnp-3806	121	6	,	,	PUNCT
fnp-3806	121	7	well	well	ADV
fnp-3806	121	8	-	-	PUNCT
fnp-3806	121	9	tolerated	tolerate	VERB
fnp-3806	121	10	progressive	progressive	ADJ
fnp-3806	121	11	slower	slow	ADJ
fnp-3806	121	12	processing	processing	NOUN
fnp-3806	121	13	,	,	PUNCT
fnp-3806	121	14	memory	memory	NOUN
fnp-3806	121	15	loss	loss	NOUN
fnp-3806	121	16	particularly	particularly	ADV
fnp-3806	121	17	related	relate	VERB
fnp-3806	121	18	to	to	ADP
fnp-3806	121	19	recent	recent	ADJ
fnp-3806	121	20	events	event	NOUN
fnp-3806	121	21	,	,	PUNCT
fnp-3806	121	22	more	more	ADJ
fnp-3806	121	23	trouble	trouble	NOUN
fnp-3806	121	24	multitasking	multitaske	VERB
fnp-3806	121	25	,	,	PUNCT
fnp-3806	121	26	slight	slight	ADJ
fnp-3806	121	27	cognitive	cognitive	ADJ
fnp-3806	121	28	decline	decline	NOUN
fnp-3806	121	29	,	,	PUNCT
fnp-3806	121	30	sleep	sleep	NOUN
fnp-3806	121	31	disorder	disorder	NOUN
fnp-3806	121	32	,	,	PUNCT
fnp-3806	121	33	emotional	emotional	ADJ
fnp-3806	121	34	changes	change	NOUN
fnp-3806	121	35	,	,	PUNCT
fnp-3806	121	36	slight	slight	ADJ
fnp-3806	121	37	or	or	CCONJ
fnp-3806	121	38	moderate	moderate	ADJ
fnp-3806	121	39	depression	depression	NOUN
fnp-3806	121	40	,	,	PUNCT
fnp-3806	121	41	and	and	CCONJ
fnp-3806	121	42	bilateral	bilateral	ADJ
fnp-3806	121	43	brain	brain	NOUN
fnp-3806	121	44	activation	activation	NOUN
fnp-3806	121	45	for	for	ADP
fnp-3806	121	46	memory	memory	NOUN
fnp-3806	121	47	functions	function	NOUN
fnp-3806	121	48	developing	develop	VERB
fnp-3806	121	49	around	around	ADP
fnp-3806	121	50	the	the	DET
fnp-3806	121	51	sixties	sixty	NOUN
fnp-3806	121	52	are	be	AUX
fnp-3806	121	53	all	all	ADV
fnp-3806	121	54	consistent	consistent	ADJ
fnp-3806	121	55	with	with	ADP
fnp-3806	121	56	“	"	PUNCT
fnp-3806	121	57	normal	normal	ADJ
fnp-3806	121	58	brain	brain	NOUN
fnp-3806	121	59	aging	aging	NOUN
fnp-3806	121	60	”	"	PUNCT
fnp-3806	121	61	.	.	PUNCT
fnp-3806	122	1	neuropathological	neuropathological	ADJ
fnp-3806	122	2	alterations	alteration	NOUN
fnp-3806	122	3	in	in	ADP
fnp-3806	122	4	normal	normal	ADJ
fnp-3806	122	5	old	old	ADJ
fnp-3806	122	6	-	-	PUNCT
fnp-3806	122	7	aged	aged	ADJ
fnp-3806	122	8	individuals	individual	NOUN
fnp-3806	122	9	are	be	AUX
fnp-3806	122	10	nfts	nft	NOUN
fnp-3806	122	11	in	in	ADP
fnp-3806	122	12	the	the	DET
fnp-3806	122	13	hippocampus	hippocampus	NOUN
fnp-3806	122	14	,	,	PUNCT
fnp-3806	122	15	entorhinal	entorhinal	ADJ
fnp-3806	122	16	cortex	cortex	NOUN
fnp-3806	122	17	,	,	PUNCT
fnp-3806	122	18	and	and	CCONJ
fnp-3806	122	19	inferior	inferior	ADJ
fnp-3806	122	20	temporal	temporal	ADJ
fnp-3806	122	21	cortex	cortex	NOUN
fnp-3806	122	22	,	,	PUNCT
fnp-3806	122	23	and	and	CCONJ
fnp-3806	122	24	very	very	ADV
fnp-3806	122	25	rarely	rarely	ADV
fnp-3806	122	26	in	in	ADP
fnp-3806	122	27	the	the	DET
fnp-3806	122	28	frontal	frontal	ADJ
fnp-3806	122	29	neocortex	neocortex	NOUN
fnp-3806	122	30	;	;	PUNCT
fnp-3806	122	31	the	the	DET
fnp-3806	122	32	distribution	distribution	NOUN
fnp-3806	122	33	of	of	ADP
fnp-3806	122	34	sps	sps	NOUN
fnp-3806	122	35	,	,	PUNCT
fnp-3806	122	36	if	if	SCONJ
fnp-3806	122	37	present	present	ADJ
fnp-3806	122	38	,	,	PUNCT
fnp-3806	122	39	is	be	AUX
fnp-3806	122	40	more	more	ADV
fnp-3806	122	41	heterogeneous	heterogeneous	ADJ
fnp-3806	122	42	(	(	PUNCT
fnp-3806	122	43	29	29	NUM
fnp-3806	122	44	-	-	SYM
fnp-3806	122	45	35	35	NUM
fnp-3806	122	46	)	)	PUNCT
fnp-3806	122	47	.	.	PUNCT
fnp-3806	123	1	clinical	clinical	ADJ
fnp-3806	123	2	and	and	CCONJ
fnp-3806	123	3	neuropathological	neuropathological	ADJ
fnp-3806	123	4	criteria	criterion	NOUN
fnp-3806	123	5	to	to	PART
fnp-3806	123	6	identify	identify	VERB
fnp-3806	123	7	borderline	borderline	NOUN
fnp-3806	123	8	cases	case	NOUN
fnp-3806	123	9	between	between	ADP
fnp-3806	123	10	ad	ad	NOUN
fnp-3806	123	11	and	and	CCONJ
fnp-3806	123	12	cognitive	cognitive	ADJ
fnp-3806	123	13	impairment	impairment	NOUN
fnp-3806	123	14	due	due	ADP
fnp-3806	123	15	to	to	ADP
fnp-3806	123	16	normal	normal	ADJ
fnp-3806	123	17	brain	brain	NOUN
fnp-3806	123	18	aging	aging	NOUN
fnp-3806	123	19	yielded	yield	VERB
fnp-3806	123	20	only	only	ADV
fnp-3806	123	21	a	a	DET
fnp-3806	123	22	limited	limited	ADJ
fnp-3806	123	23	consensus	consensus	NOUN
fnp-3806	123	24	(	(	PUNCT
fnp-3806	123	25	36	36	NUM
fnp-3806	123	26	,	,	PUNCT
fnp-3806	123	27	37	37	NUM
fnp-3806	123	28	)	)	PUNCT
fnp-3806	123	29	.	.	PUNCT
fnp-3806	124	1	a	a	DET
fnp-3806	124	2	few	few	ADJ
fnp-3806	124	3	years	year	NOUN
fnp-3806	124	4	later	later	ADV
fnp-3806	124	5	,	,	PUNCT
fnp-3806	124	6	cerad	cerad	PROPN
fnp-3806	124	7	proposed	propose	VERB
fnp-3806	124	8	a	a	DET
fnp-3806	124	9	neuritic	neuritic	ADJ
fnp-3806	124	10	plaque	plaque	NOUN
fnp-3806	124	11	score	score	NOUN
fnp-3806	124	12	based	base	VERB
fnp-3806	124	13	on	on	ADP
fnp-3806	124	14	the	the	DET
fnp-3806	124	15	number	number	NOUN
fnp-3806	124	16	of	of	ADP
fnp-3806	124	17	plaques	plaque	NOUN
fnp-3806	124	18	per	per	ADP
fnp-3806	124	19	mm2	mm2	NOUN
fnp-3806	124	20	and	and	CCONJ
fnp-3806	124	21	the	the	DET
fnp-3806	124	22	age	age	NOUN
fnp-3806	124	23	of	of	ADP
fnp-3806	124	24	the	the	DET
fnp-3806	124	25	individual	individual	NOUN
fnp-3806	124	26	to	to	PART
fnp-3806	124	27	categorize	categorize	VERB
fnp-3806	124	28	ad	ad	NOUN
fnp-3806	124	29	in	in	ADP
fnp-3806	124	30	comparison	comparison	NOUN
fnp-3806	124	31	to	to	ADP
fnp-3806	124	32	normal	normal	ADJ
fnp-3806	124	33	brain	brain	NOUN
fnp-3806	124	34	aging	aging	NOUN
fnp-3806	124	35	(	(	PUNCT
fnp-3806	124	36	38	38	NUM
fnp-3806	124	37	,	,	PUNCT
fnp-3806	124	38	39	39	NUM
fnp-3806	124	39	)	)	PUNCT
fnp-3806	124	40	.	.	PUNCT
fnp-3806	125	1	evidence	evidence	NOUN
fnp-3806	125	2	of	of	ADP
fnp-3806	125	3	a	a	DET
fnp-3806	125	4	clinical	clinical	ADJ
fnp-3806	125	5	progression	progression	NOUN
fnp-3806	125	6	and	and	CCONJ
fnp-3806	125	7	post	post	ADJ
fnp-3806	125	8	-	-	ADJ
fnp-3806	125	9	mortem	mortem	ADJ
fnp-3806	125	10	neuropathological	neuropathological	ADJ
fnp-3806	125	11	observations	observation	NOUN
fnp-3806	125	12	showing	show	VERB
fnp-3806	125	13	a	a	DET
fnp-3806	125	14	concatenation	concatenation	NOUN
fnp-3806	125	15	of	of	ADP
fnp-3806	125	16	ad	ad	NOUN
fnp-3806	125	17	-	-	PUNCT
fnp-3806	125	18	related	relate	VERB
fnp-3806	125	19	changes	change	NOUN
fnp-3806	125	20	in	in	ADP
fnp-3806	125	21	old	old	ADJ
fnp-3806	125	22	age	age	NOUN
fnp-3806	125	23	and	and	CCONJ
fnp-3806	125	24	sad	sad	ADJ
fnp-3806	125	25	(	(	PUNCT
fnp-3806	125	26	29	29	NUM
fnp-3806	125	27	-	-	SYM
fnp-3806	125	28	32	32	NUM
fnp-3806	125	29	,	,	PUNCT
fnp-3806	125	30	40	40	NUM
fnp-3806	125	31	-	-	SYM
fnp-3806	125	32	43	43	NUM
fnp-3806	125	33	)	)	PUNCT
fnp-3806	125	34	prompted	prompt	VERB
fnp-3806	125	35	a	a	DET
fnp-3806	125	36	clinical	clinical	ADJ
fnp-3806	125	37	redefinition	redefinition	NOUN
fnp-3806	125	38	of	of	ADP
fnp-3806	125	39	ad	ad	NOUN
fnp-3806	125	40	at	at	ADP
fnp-3806	125	41	the	the	DET
fnp-3806	125	42	beginning	beginning	NOUN
fnp-3806	125	43	of	of	ADP
fnp-3806	125	44	the	the	DET
fnp-3806	125	45	second	second	ADJ
fnp-3806	125	46	decade	decade	NOUN
fnp-3806	125	47	of	of	ADP
fnp-3806	125	48	this	this	DET
fnp-3806	125	49	century	century	NOUN
fnp-3806	125	50	.	.	PUNCT
fnp-3806	126	1	a	a	DET
fnp-3806	126	2	crucial	crucial	ADJ
fnp-3806	126	3	approach	approach	NOUN
fnp-3806	126	4	was	be	AUX
fnp-3806	126	5	the	the	DET
fnp-3806	126	6	combination	combination	NOUN
fnp-3806	126	7	of	of	ADP
fnp-3806	126	8	clinical	clinical	ADJ
fnp-3806	126	9	criteria	criterion	NOUN
fnp-3806	126	10	,	,	PUNCT
fnp-3806	126	11	biochemical	biochemical	ADJ
fnp-3806	126	12	biomarkers	biomarker	NOUN
fnp-3806	126	13	in	in	ADP
fnp-3806	126	14	body	body	NOUN
fnp-3806	126	15	fluids	fluid	NOUN
fnp-3806	126	16	,	,	PUNCT
fnp-3806	126	17	and	and	CCONJ
fnp-3806	126	18	neuroimaging	neuroimaging	NOUN
fnp-3806	126	19	techniques	technique	NOUN
fnp-3806	126	20	to	to	PART
fnp-3806	126	21	define	define	VERB
fnp-3806	126	22	the	the	DET
fnp-3806	126	23	diagnosis	diagnosis	NOUN
fnp-3806	126	24	of	of	ADP
fnp-3806	126	25	preclinical	preclinical	ADJ
fnp-3806	126	26	ad	ad	NOUN
fnp-3806	126	27	,	,	PUNCT
fnp-3806	126	28	mild	mild	ADJ
fnp-3806	126	29	cognitive	cognitive	ADJ
fnp-3806	126	30	impairment	impairment	NOUN
fnp-3806	126	31	(	(	PUNCT
fnp-3806	126	32	mci	mci	NOUN
fnp-3806	126	33	)	)	PUNCT
fnp-3806	126	34	due	due	ADP
fnp-3806	126	35	to	to	ADP
fnp-3806	126	36	ad	ad	NOUN
fnp-3806	126	37	,	,	PUNCT
fnp-3806	126	38	and	and	CCONJ
fnp-3806	126	39	ad	ad	NOUN
fnp-3806	126	40	(	(	PUNCT
fnp-3806	126	41	44	44	NUM
fnp-3806	126	42	-	-	SYM
fnp-3806	126	43	50	50	NUM
fnp-3806	126	44	)	)	PUNCT
fnp-3806	126	45	.	.	PUNCT
fnp-3806	127	1	more	more	ADV
fnp-3806	127	2	precise	precise	ADJ
fnp-3806	127	3	clinical	clinical	ADJ
fnp-3806	127	4	definitions	definition	NOUN
fnp-3806	127	5	have	have	AUX
fnp-3806	127	6	been	be	AUX
fnp-3806	127	7	proposed	propose	VERB
fnp-3806	127	8	to	to	PART
fnp-3806	127	9	categorize	categorize	VERB
fnp-3806	127	10	different	different	ADJ
fnp-3806	127	11	stages	stage	NOUN
fnp-3806	127	12	of	of	ADP
fnp-3806	127	13	ad	ad	NOUN
fnp-3806	127	14	(	(	PUNCT
fnp-3806	127	15	51	51	NUM
fnp-3806	127	16	)	)	PUNCT
fnp-3806	127	17	.	.	PUNCT
fnp-3806	128	1	the	the	DET
fnp-3806	128	2	classification	classification	NOUN
fnp-3806	128	3	shown	show	VERB
fnp-3806	128	4	in	in	ADP
fnp-3806	128	5	box	box	PROPN
fnp-3806	128	6	1	1	NUM
fnp-3806	128	7	is	be	AUX
fnp-3806	128	8	a	a	DET
fnp-3806	128	9	summarized	summarize	VERB
fnp-3806	128	10	transcription	transcription	NOUN
fnp-3806	128	11	of	of	ADP
fnp-3806	128	12	the	the	DET
fnp-3806	128	13	alzheimer	alzheimer	PROPN
fnp-3806	128	14	’s	’s	PROPN
fnp-3806	128	15	association	association	NOUN
fnp-3806	128	16	report	report	NOUN
fnp-3806	128	17	:	:	PUNCT
fnp-3806	128	18	2022	2022	NUM
fnp-3806	128	19	alzheimer	alzheimer	PROPN
fnp-3806	128	20	’s	’s	PART
fnp-3806	128	21	disease	disease	NOUN
fnp-3806	128	22	facts	fact	NOUN
fnp-3806	128	23	and	and	CCONJ
fnp-3806	128	24	figures	figure	NOUN
fnp-3806	128	25	(	(	PUNCT
fnp-3806	128	26	https://www.alz.org/media/documents/alzheimers-facts-and-figures.pdf	https://www.alz.org/media/documents/alzheimers-facts-and-figures.pdf	PROPN
fnp-3806	128	27	)	)	PUNCT
fnp-3806	128	28	.	.	PUNCT
fnp-3806	129	1	the	the	DET
fnp-3806	129	2	american	american	PROPN
fnp-3806	129	3	academy	academy	PROPN
fnp-3806	129	4	of	of	ADP
fnp-3806	129	5	neurology	neurology	NOUN
fnp-3806	129	6	estimates	estimate	VERB
fnp-3806	129	7	that	that	SCONJ
fnp-3806	129	8	mci	mci	PROPN
fnp-3806	129	9	is	be	AUX
fnp-3806	129	10	present	present	ADJ
fnp-3806	129	11	in	in	ADP
fnp-3806	129	12	about	about	ADV
fnp-3806	129	13	8	8	NUM
fnp-3806	129	14	%	%	NOUN
fnp-3806	129	15	of	of	ADP
fnp-3806	129	16	people	people	NOUN
fnp-3806	129	17	age	age	NOUN
fnp-3806	129	18	65	65	NUM
fnp-3806	129	19	to	to	PART
fnp-3806	129	20	69	69	NUM
fnp-3806	129	21	,	,	PUNCT
fnp-3806	129	22	in	in	ADP
fnp-3806	129	23	15	15	NUM
fnp-3806	129	24	%	%	NOUN
fnp-3806	129	25	of	of	ADP
fnp-3806	129	26	75to	75to	ADJ
fnp-3806	129	27	79	79	NUM
fnp-3806	129	28	-	-	PUNCT
fnp-3806	129	29	year	year	NOUN
fnp-3806	129	30	-	-	PUNCT
fnp-3806	129	31	olds	old	NOUN
fnp-3806	129	32	,	,	PUNCT
fnp-3806	129	33	in	in	ADP
fnp-3806	129	34	25	25	NUM
fnp-3806	129	35	%	%	NOUN
fnp-3806	129	36	of	of	ADP
fnp-3806	129	37	those	those	DET
fnp-3806	129	38	age	age	NOUN
fnp-3806	129	39	80	80	NUM
fnp-3806	129	40	to	to	ADP
fnp-3806	129	41	84	84	NUM
fnp-3806	129	42	,	,	PUNCT
fnp-3806	129	43	and	and	CCONJ
fnp-3806	129	44	in	in	ADP
fnp-3806	129	45	about	about	ADV
fnp-3806	129	46	37	37	NUM
fnp-3806	129	47	%	%	NOUN
fnp-3806	129	48	of	of	ADP
fnp-3806	129	49	people	people	NOUN
fnp-3806	129	50	85	85	NUM
fnp-3806	129	51	years	year	NOUN
fnp-3806	129	52	of	of	ADP
fnp-3806	129	53	age	age	NOUN
fnp-3806	129	54	and	and	CCONJ
fnp-3806	129	55	older	old	ADJ
fnp-3806	129	56	.	.	PUNCT
fnp-3806	130	1	about	about	ADV
fnp-3806	130	2	7.5	7.5	NUM
fnp-3806	130	3	%	%	NOUN
fnp-3806	130	4	will	will	AUX
fnp-3806	130	5	develop	develop	VERB
fnp-3806	130	6	dementia	dementia	NOUN
fnp-3806	130	7	in	in	ADP
fnp-3806	130	8	the	the	DET
fnp-3806	130	9	first	first	ADJ
fnp-3806	130	10	year	year	NOUN
fnp-3806	130	11	after	after	ADP
fnp-3806	130	12	diagnosis	diagnosis	NOUN
fnp-3806	130	13	of	of	ADP
fnp-3806	130	14	mci	mci	NOUN
fnp-3806	130	15	;	;	PUNCT
fnp-3806	130	16	about	about	ADV
fnp-3806	130	17	15	15	NUM
fnp-3806	130	18	%	%	NOUN
fnp-3806	130	19	will	will	AUX
fnp-3806	130	20	develop	develop	VERB
fnp-3806	130	21	dementia	dementia	NOUN
fnp-3806	130	22	in	in	ADP
fnp-3806	130	23	the	the	DET
fnp-3806	130	24	second	second	ADJ
fnp-3806	130	25	year	year	NOUN
fnp-3806	130	26	;	;	PUNCT
fnp-3806	130	27	about	about	ADV
fnp-3806	130	28	one	one	NUM
fnp-3806	130	29	third	third	NOUN
fnp-3806	130	30	will	will	AUX
fnp-3806	130	31	develop	develop	VERB
fnp-3806	130	32	dementia	dementia	NOUN
fnp-3806	130	33	due	due	ADP
fnp-3806	130	34	to	to	ADP
fnp-3806	130	35	ad	ad	NOUN
fnp-3806	130	36	within	within	ADP
fnp-3806	130	37	five	five	NUM
fnp-3806	130	38	years	year	NOUN
fnp-3806	130	39	(	(	PUNCT
fnp-3806	130	40	52	52	NUM
fnp-3806	130	41	,	,	PUNCT
fnp-3806	130	42	53	53	NUM
fnp-3806	130	43	)	)	PUNCT
fnp-3806	130	44	.	.	PUNCT
fnp-3806	131	1	the	the	DET
fnp-3806	131	2	prevalence	prevalence	NOUN
fnp-3806	131	3	of	of	ADP
fnp-3806	131	4	dementia	dementia	NOUN
fnp-3806	131	5	in	in	ADP
fnp-3806	131	6	65	65	NUM
fnp-3806	131	7	-	-	SYM
fnp-3806	131	8	69	69	NUM
fnp-3806	131	9	-	-	PUNCT
fnp-3806	131	10	year	year	NOUN
fnp-3806	131	11	-	-	PUNCT
fnp-3806	131	12	olds	old	NOUN
fnp-3806	131	13	is	be	AUX
fnp-3806	131	14	approximately	approximately	ADV
fnp-3806	131	15	0.01	0.01	NUM
fnp-3806	131	16	%	%	NOUN
fnp-3806	131	17	of	of	ADP
fnp-3806	131	18	individuals	individual	NOUN
fnp-3806	131	19	;	;	PUNCT
fnp-3806	131	20	the	the	DET
fnp-3806	131	21	prevalence	prevalence	NOUN
fnp-3806	131	22	of	of	ADP
fnp-3806	131	23	dementia	dementia	NOUN
fnp-3806	131	24	doubles	double	VERB
fnp-3806	131	25	with	with	ADP
fnp-3806	131	26	increments	increment	NOUN
fnp-3806	131	27	of	of	ADP
fnp-3806	131	28	five	five	NUM
fnp-3806	131	29	years	year	NOUN
fnp-3806	131	30	;	;	PUNCT
fnp-3806	131	31	thereby	thereby	ADV
fnp-3806	131	32	,	,	PUNCT
fnp-3806	131	33	between	between	SCONJ
fnp-3806	131	34	25	25	NUM
fnp-3806	131	35	%	%	NOUN
fnp-3806	131	36	and	and	CCONJ
fnp-3806	131	37	50	50	NUM
fnp-3806	131	38	%	%	NOUN
fnp-3806	131	39	of	of	ADP
fnp-3806	131	40	individuals	individual	NOUN
fnp-3806	131	41	over	over	ADP
fnp-3806	131	42	the	the	DET
fnp-3806	131	43	age	age	NOUN
fnp-3806	131	44	of	of	ADP
fnp-3806	131	45	85	85	NUM
fnp-3806	131	46	suffer	suffer	VERB
fnp-3806	131	47	from	from	ADP
fnp-3806	131	48	dementia	dementia	NOUN
fnp-3806	131	49	(	(	PUNCT
fnp-3806	131	50	2	2	NUM
fnp-3806	131	51	)	)	PUNCT
fnp-3806	131	52	.	.	PUNCT
fnp-3806	132	1	it	it	PRON
fnp-3806	132	2	is	be	AUX
fnp-3806	132	3	estimated	estimate	VERB
fnp-3806	132	4	that	that	SCONJ
fnp-3806	132	5	between	between	ADP
fnp-3806	132	6	50	50	NUM
fnp-3806	132	7	%	%	NOUN
fnp-3806	132	8	and	and	CCONJ
fnp-3806	132	9	80	80	NUM
fnp-3806	132	10	%	%	NOUN
fnp-3806	132	11	of	of	ADP
fnp-3806	132	12	cases	case	NOUN
fnp-3806	132	13	with	with	ADP
fnp-3806	132	14	dementia	dementia	NOUN
fnp-3806	132	15	have	have	VERB
fnp-3806	132	16	ad	ad	NOUN
fnp-3806	132	17	(	(	PUNCT
fnp-3806	132	18	2	2	NUM
fnp-3806	132	19	)	)	PUNCT
fnp-3806	132	20	.	.	PUNCT
fnp-3806	133	1	age	age	NOUN
fnp-3806	133	2	,	,	PUNCT
fnp-3806	133	3	gender	gender	NOUN
fnp-3806	133	4	,	,	PUNCT
fnp-3806	133	5	race	race	NOUN
fnp-3806	133	6	,	,	PUNCT
fnp-3806	133	7	living	living	NOUN
fnp-3806	133	8	conditions	condition	NOUN
fnp-3806	133	9	,	,	PUNCT
fnp-3806	133	10	and	and	CCONJ
fnp-3806	133	11	genetic	genetic	ADJ
fnp-3806	133	12	factors	factor	NOUN
fnp-3806	133	13	mark	mark	VERB
fnp-3806	133	14	differences	difference	NOUN
fnp-3806	133	15	in	in	ADP
fnp-3806	133	16	the	the	DET
fnp-3806	133	17	duration	duration	NOUN
fnp-3806	133	18	of	of	ADP
fnp-3806	133	19	preclinical	preclinical	ADJ
fnp-3806	133	20	and	and	CCONJ
fnp-3806	133	21	dementia	dementia	NOUN
fnp-3806	133	22	stages	stage	NOUN
fnp-3806	133	23	in	in	ADP
fnp-3806	133	24	sad	sad	ADJ
fnp-3806	133	25	(	(	PUNCT
fnp-3806	133	26	54	54	NUM
fnp-3806	133	27	,	,	PUNCT
fnp-3806	133	28	55	55	NUM
fnp-3806	133	29	)	)	PUNCT
fnp-3806	133	30	.	.	PUNCT
fnp-3806	134	1	2	2	X
fnp-3806	134	2	.	.	X
fnp-3806	134	3	β	β	X
fnp-3806	134	4	-	-	PUNCT
fnp-3806	134	5	amyloid	amyloid	NOUN
fnp-3806	134	6	and	and	CCONJ
fnp-3806	134	7	tau	tau	PROPN
fnp-3806	134	8	electron	electron	NOUN
fnp-3806	134	9	microscopic	microscopic	PROPN
fnp-3806	134	10	studies	study	NOUN
fnp-3806	134	11	revealed	reveal	VERB
fnp-3806	134	12	that	that	SCONJ
fnp-3806	134	13	nfts	nft	NOUN
fnp-3806	134	14	were	be	AUX
fnp-3806	134	15	composed	compose	VERB
fnp-3806	134	16	of	of	ADP
fnp-3806	134	17	paired	pair	VERB
fnp-3806	134	18	helical	helical	ADJ
fnp-3806	134	19	filaments	filament	NOUN
fnp-3806	134	20	(	(	PUNCT
fnp-3806	134	21	phfs	phfs	NOUN
fnp-3806	134	22	)	)	PUNCT
fnp-3806	134	23	that	that	PRON
fnp-3806	134	24	disrupted	disrupt	VERB
fnp-3806	134	25	the	the	DET
fnp-3806	134	26	architecture	architecture	NOUN
fnp-3806	134	27	of	of	ADP
fnp-3806	134	28	the	the	DET
fnp-3806	134	29	cyto	cyto	PROPN
fnp-3806	134	30	-	-	PUNCT
fnp-3806	134	31	skeleton	skeleton	PROPN
fnp-3806	134	32	.	.	PUNCT
fnp-3806	135	1	sps	sps	PROPN
fnp-3806	135	2	were	be	AUX
fnp-3806	135	3	forged	forge	VERB
fnp-3806	135	4	from	from	ADP
fnp-3806	135	5	a	a	DET
fnp-3806	135	6	core	core	NOUN
fnp-3806	135	7	of	of	ADP
fnp-3806	135	8	compact	compact	ADJ
fnp-3806	135	9	fibrils	fibril	NOUN
fnp-3806	135	10	consistent	consistent	ADJ
fnp-3806	135	11	with	with	ADP
fnp-3806	135	12	amyloids	amyloid	NOUN
fnp-3806	135	13	surrounded	surround	VERB
fnp-3806	135	14	by	by	ADP
fnp-3806	135	15	dystrophic	dystrophic	ADJ
fnp-3806	135	16	neurites	neurite	NOUN
fnp-3806	135	17	filled	fill	VERB
fnp-3806	135	18	with	with	ADP
fnp-3806	135	19	altered	altered	ADJ
fnp-3806	135	20	mitochondria	mitochondria	NOUN
fnp-3806	135	21	,	,	PUNCT
fnp-3806	135	22	vesicles	vesicle	NOUN
fnp-3806	135	23	,	,	PUNCT
fnp-3806	135	24	numerous	numerous	ADJ
fnp-3806	135	25	pleomorphic	pleomorphic	ADJ
fnp-3806	135	26	residual	residual	ADJ
fnp-3806	135	27	bodies	body	NOUN
fnp-3806	135	28	,	,	PUNCT
fnp-3806	135	29	and	and	CCONJ
fnp-3806	135	30	phfs	phfs	ADJ
fnp-3806	135	31	(	(	PUNCT
fnp-3806	135	32	56	56	NUM
fnp-3806	135	33	-	-	SYM
fnp-3806	135	34	61	61	NUM
fnp-3806	135	35	)	)	PUNCT
fnp-3806	135	36	(	(	PUNCT
fnp-3806	135	37	figure	figure	NOUN
fnp-3806	135	38	3	3	NUM
fnp-3806	135	39	)	)	PUNCT
fnp-3806	135	40	.	.	PUNCT
fnp-3806	136	1	figure	figure	VERB
fnp-3806	136	2	3	3	NUM
fnp-3806	136	3	:	:	PUNCT
fnp-3806	136	4	electron	electron	NOUN
fnp-3806	136	5	microscopy	microscopy	NOUN
fnp-3806	136	6	of	of	ADP
fnp-3806	136	7	an	an	DET
fnp-3806	136	8	sp	sp	NOUN
fnp-3806	136	9	showing	show	VERB
fnp-3806	136	10	the	the	DET
fnp-3806	136	11	central	central	ADJ
fnp-3806	136	12	core	core	NOUN
fnp-3806	136	13	of	of	ADP
fnp-3806	136	14	amyloid	amyloid	NOUN
fnp-3806	136	15	fibrils	fibril	NOUN
fnp-3806	136	16	(	(	PUNCT
fnp-3806	136	17	asterisk	asterisk	NOUN
fnp-3806	136	18	)	)	PUNCT
fnp-3806	136	19	and	and	CCONJ
fnp-3806	136	20	peripheral	peripheral	ADJ
fnp-3806	136	21	dystrophic	dystrophic	ADJ
fnp-3806	136	22	neurites	neurite	NOUN
fnp-3806	136	23	(	(	PUNCT
fnp-3806	136	24	black	black	ADJ
fnp-3806	136	25	arrows	arrow	NOUN
fnp-3806	136	26	)	)	PUNCT
fnp-3806	136	27	filled	fill	VERB
fnp-3806	136	28	with	with	ADP
fnp-3806	136	29	vesicles	vesicle	NOUN
fnp-3806	136	30	,	,	PUNCT
fnp-3806	136	31	dense	dense	ADJ
fnp-3806	136	32	bodies	body	NOUN
fnp-3806	136	33	,	,	PUNCT
fnp-3806	136	34	abnormal	abnormal	ADJ
fnp-3806	136	35	mitochondria	mitochondria	NOUN
fnp-3806	136	36	,	,	PUNCT
fnp-3806	136	37	and	and	CCONJ
fnp-3806	136	38	paired	pair	VERB
fnp-3806	136	39	helical	helical	ADJ
fnp-3806	136	40	filaments	filament	NOUN
fnp-3806	136	41	;	;	PUNCT
fnp-3806	136	42	bar	bar	NOUN
fnp-3806	136	43	=	=	SYM
fnp-3806	136	44	5μm	5μm	NUM
fnp-3806	136	45	.	.	PUNCT
fnp-3806	137	1	2a	2a	NUM
fnp-3806	137	2	.	.	PUNCT
fnp-3806	138	1	β	β	X
fnp-3806	138	2	-	-	PUNCT
fnp-3806	138	3	amyloid	amyloid	NOUN
fnp-3806	138	4	(	(	PUNCT
fnp-3806	138	5	aβ	aβ	NOUN
fnp-3806	138	6	)	)	PUNCT
fnp-3806	138	7	subsequently	subsequently	ADV
fnp-3806	138	8	,	,	PUNCT
fnp-3806	138	9	molecular	molecular	ADJ
fnp-3806	138	10	studies	study	NOUN
fnp-3806	138	11	identified	identify	VERB
fnp-3806	138	12	β	β	NOUN
fnp-3806	138	13	-	-	NOUN
fnp-3806	138	14	amyloid	amyloid	NOUN
fnp-3806	138	15	as	as	ADP
fnp-3806	138	16	the	the	DET
fnp-3806	138	17	main	main	ADJ
fnp-3806	138	18	component	component	NOUN
fnp-3806	138	19	of	of	ADP
fnp-3806	138	20	cerebral	cerebral	ADJ
fnp-3806	138	21	amyloid	amyloid	NOUN
fnp-3806	138	22	in	in	ADP
fnp-3806	138	23	β	β	NOUN
fnp-3806	138	24	-	-	NOUN
fnp-3806	138	25	amyloid	amyloid	ADJ
fnp-3806	138	26	angiopathy	angiopathy	NOUN
fnp-3806	138	27	and	and	CCONJ
fnp-3806	138	28	sps	sps	PROPN
fnp-3806	138	29	(	(	PUNCT
fnp-3806	138	30	62	62	NUM
fnp-3806	138	31	-	-	SYM
fnp-3806	138	32	66	66	NUM
fnp-3806	138	33	)	)	PUNCT
fnp-3806	138	34	.	.	PUNCT
fnp-3806	139	1	the	the	DET
fnp-3806	139	2	amyloid	amyloid	NOUN
fnp-3806	139	3	precursor	precursor	NOUN
fnp-3806	139	4	protein	protein	NOUN
fnp-3806	139	5	(	(	PUNCT
fnp-3806	139	6	app	app	X
fnp-3806	139	7	)	)	PUNCT
fnp-3806	139	8	is	be	AUX
fnp-3806	139	9	a	a	DET
fnp-3806	139	10	transmembrane	transmembrane	ADJ
fnp-3806	139	11	protein	protein	NOUN
fnp-3806	139	12	which	which	PRON
fnp-3806	139	13	modulates	modulate	VERB
fnp-3806	139	14	brain	brain	NOUN
fnp-3806	139	15	cell	cell	NOUN
fnp-3806	139	16	adhesion	adhesion	NOUN
fnp-3806	139	17	,	,	PUNCT
fnp-3806	139	18	synaptic	synaptic	ADJ
fnp-3806	139	19	plasticity	plasticity	NOUN
fnp-3806	139	20	,	,	PUNCT
fnp-3806	139	21	and	and	CCONJ
fnp-3806	139	22	multiple	multiple	ADJ
fnp-3806	139	23	intracellular	intracellular	NOUN
fnp-3806	139	24	signaling	signal	VERB
fnp-3806	139	25	through	through	ADP
fnp-3806	139	26	the	the	DET
fnp-3806	139	27	small	small	ADJ
fnp-3806	139	28	endodomain	endodomain	NOUN
fnp-3806	139	29	of	of	ADP
fnp-3806	139	30	the	the	DET
fnp-3806	139	31	molecule	molecule	NOUN
fnp-3806	139	32	.	.	PUNCT
fnp-3806	140	1	app	app	NOUN
fnp-3806	140	2	processing	processing	NOUN
fnp-3806	140	3	is	be	AUX
fnp-3806	140	4	regulated	regulate	VERB
fnp-3806	140	5	by	by	ADP
fnp-3806	140	6	cytoplasmic	cytoplasmic	ADJ
fnp-3806	140	7	phosphorylation	phosphorylation	NOUN
fnp-3806	140	8	(	(	PUNCT
fnp-3806	140	9	67	67	NUM
fnp-3806	140	10	)	)	PUNCT
fnp-3806	140	11	.	.	PUNCT
fnp-3806	141	1	cleavage	cleavage	NOUN
fnp-3806	141	2	of	of	ADP
fnp-3806	141	3	app	app	PROPN
fnp-3806	141	4	occurs	occur	VERB
fnp-3806	141	5	through	through	ADP
fnp-3806	141	6	the	the	DET
fnp-3806	141	7	combined	combine	VERB
fnp-3806	141	8	action	action	NOUN
fnp-3806	141	9	of	of	ADP
fnp-3806	141	10	α-	α-	NUM
fnp-3806	141	11	,	,	PUNCT
fnp-3806	141	12	β-	β-	X
fnp-3806	141	13	,	,	PUNCT
fnp-3806	141	14	and	and	CCONJ
fnp-3806	141	15	δ	δ	NOUN
fnp-3806	141	16	-	-	PUNCT
fnp-3806	141	17	secretases	secretase	NOUN
fnp-3806	141	18	.	.	PUNCT
fnp-3806	142	1	β	β	X
fnp-3806	142	2	-	-	PUNCT
fnp-3806	142	3	secretase	secretase	ADJ
fnp-3806	142	4	(	(	PUNCT
fnp-3806	142	5	bace	bace	PROPN
fnp-3806	142	6	)	)	PUNCT
fnp-3806	142	7	is	be	AUX
fnp-3806	142	8	a	a	DET
fnp-3806	142	9	gpi	gpi	NOUN
fnp-3806	142	10	-	-	PUNCT
fnp-3806	142	11	anchored	anchor	VERB
fnp-3806	142	12	aspartyl	aspartyl	NOUN
fnp-3806	142	13	protease	protease	NOUN
fnp-3806	142	14	(	(	PUNCT
fnp-3806	142	15	68	68	NUM
fnp-3806	142	16	)	)	PUNCT
fnp-3806	142	17	.	.	PUNCT
fnp-3806	143	1	γ	γ	X
fnp-3806	143	2	-	-	PUNCT
fnp-3806	143	3	secretase	secretase	NOUN
fnp-3806	143	4	is	be	AUX
fnp-3806	143	5	a	a	DET
fnp-3806	143	6	coprotein	coprotein	ADJ
fnp-3806	143	7	complex	complex	NOUN
fnp-3806	143	8	mainly	mainly	ADV
fnp-3806	143	9	composed	compose	VERB
fnp-3806	143	10	of	of	ADP
fnp-3806	143	11	presenilin	presenilin	PROPN
fnp-3806	143	12	1	1	NUM
fnp-3806	143	13	(	(	PUNCT
fnp-3806	143	14	psen1	psen1	ADJ
fnp-3806	143	15	)	)	PUNCT
fnp-3806	143	16	and	and	CCONJ
fnp-3806	143	17	presenilin	presenilin	PROPN
fnp-3806	143	18	2	2	NUM
fnp-3806	143	19	(	(	PUNCT
fnp-3806	143	20	psen2	psen2	NOUN
fnp-3806	143	21	)	)	PUNCT
fnp-3806	143	22	;	;	PUNCT
fnp-3806	143	23	components	component	NOUN
fnp-3806	143	24	of	of	ADP
fnp-3806	143	25	the	the	DET
fnp-3806	143	26	γ	γ	PROPN
fnp-3806	143	27	-	-	ADJ
fnp-3806	143	28	secretase	secretase	ADJ
fnp-3806	143	29	complex	complex	NOUN
fnp-3806	143	30	aph-1	aph-1	PUNCT
fnp-3806	143	31	homolog	homolog	NOUN
fnp-3806	143	32	a	a	X
fnp-3806	143	33	;	;	PUNCT
fnp-3806	143	34	γ	γ	X
fnp-3806	143	35	-	-	PUNCT
fnp-3806	143	36	secretase	secretase	ADJ
fnp-3806	143	37	subunit	subunit	NOUN
fnp-3806	143	38	(	(	PUNCT
fnp-3806	143	39	aph1a	aph1a	PROPN
fnp-3806	143	40	)	)	PUNCT
fnp-3806	143	41	;	;	PUNCT
fnp-3806	143	42	aph1b	aph1b	PROPN
fnp-3806	143	43	;	;	PUNCT
fnp-3806	143	44	nicastrin	nicastrin	X
fnp-3806	143	45	(	(	PUNCT
fnp-3806	143	46	nct	nct	ADJ
fnp-3806	143	47	/	/	SYM
fnp-3806	143	48	ncstn	ncstn	NOUN
fnp-3806	143	49	)	)	PUNCT
fnp-3806	143	50	;	;	PUNCT
fnp-3806	143	51	and	and	CCONJ
fnp-3806	143	52	presenilin	presenilin	PROPN
fnp-3806	143	53	enhancer	enhancer	NOUN
fnp-3806	143	54	γ	γ	PROPN
fnp-3806	143	55	-	-	ADJ
fnp-3806	143	56	secretase	secretase	ADJ
fnp-3806	143	57	subunit	subunit	NOUN
fnp-3806	143	58	(	(	PUNCT
fnp-3806	143	59	pen2	pen2	NOUN
fnp-3806	143	60	/	/	SYM
fnp-3806	143	61	psenen	psenen	NOUN
fnp-3806	143	62	)	)	PUNCT
fnp-3806	143	63	,	,	PUNCT
fnp-3806	143	64	together	together	ADV
fnp-3806	143	65	with	with	ADP
fnp-3806	143	66	the	the	DET
fnp-3806	143	67	modulators	modulator	NOUN
fnp-3806	143	68	neprilysin	neprilysin	NOUN
fnp-3806	143	69	(	(	PUNCT
fnp-3806	143	70	nep	nep	NOUN
fnp-3806	143	71	/	/	SYM
fnp-3806	143	72	mme	mme	NOUN
fnp-3806	143	73	)	)	PUNCT
fnp-3806	143	74	and	and	CCONJ
fnp-3806	143	75	insulin	insulin	NOUN
fnp-3806	143	76	-	-	PUNCT
fnp-3806	143	77	degrading	degrade	VERB
fnp-3806	143	78	enzyme	enzyme	NOUN
fnp-3806	143	79	(	(	PUNCT
fnp-3806	143	80	ide	ide	NOUN
fnp-3806	143	81	)	)	PUNCT
fnp-3806	143	82	.	.	PUNCT
fnp-3806	144	1	the	the	DET
fnp-3806	144	2	γ	γ	PROPN
fnp-3806	144	3	-	-	ADJ
fnp-3806	144	4	secretase	secretase	ADJ
fnp-3806	144	5	complex	complex	NOUN
fnp-3806	144	6	is	be	AUX
fnp-3806	144	7	considered	consider	VERB
fnp-3806	144	8	the	the	DET
fnp-3806	144	9	“	"	PUNCT
fnp-3806	144	10	proteasome	proteasome	NOUN
fnp-3806	144	11	of	of	ADP
fnp-3806	144	12	the	the	DET
fnp-3806	144	13	membrane	membrane	NOUN
fnp-3806	144	14	”	"	PUNCT
fnp-3806	144	15	because	because	SCONJ
fnp-3806	144	16	of	of	ADP
fnp-3806	144	17	its	its	PRON
fnp-3806	144	18	capacity	capacity	NOUN
fnp-3806	144	19	to	to	PART
fnp-3806	144	20	act	act	VERB
fnp-3806	144	21	as	as	ADP
fnp-3806	144	22	a	a	DET
fnp-3806	144	23	protelytic	protelytic	ADJ
fnp-3806	144	24	enzyme	enzyme	NOUN
fnp-3806	144	25	on	on	ADP
fnp-3806	144	26	more	more	ADJ
fnp-3806	144	27	than	than	ADP
fnp-3806	144	28	90	90	NUM
fnp-3806	144	29	substrates	substrate	NOUN
fnp-3806	144	30	(	(	PUNCT
fnp-3806	144	31	69	69	NUM
fnp-3806	144	32	-	-	SYM
fnp-3806	144	33	71	71	NUM
fnp-3806	144	34	)	)	PUNCT
fnp-3806	144	35	.	.	PUNCT
fnp-3806	145	1	cleavage	cleavage	NOUN
fnp-3806	145	2	of	of	ADP
fnp-3806	145	3	app	app	NOUN
fnp-3806	145	4	through	through	ADP
fnp-3806	145	5	αand	αand	PROPN
fnp-3806	145	6	δ	δ	PROPN
fnp-3806	145	7	-	-	PUNCT
fnp-3806	145	8	secretase	secretase	NOUN
fnp-3806	145	9	leads	lead	VERB
fnp-3806	145	10	to	to	ADP
fnp-3806	145	11	the	the	DET
fnp-3806	145	12	non	non	ADJ
fnp-3806	145	13	-	-	ADJ
fnp-3806	145	14	amyloidogenic	amyloidogenic	ADJ
fnp-3806	145	15	pathway	pathway	NOUN
fnp-3806	145	16	of	of	ADP
fnp-3806	145	17	app	app	NOUN
fnp-3806	145	18	degradation	degradation	NOUN
fnp-3806	145	19	,	,	PUNCT
fnp-3806	145	20	whereas	whereas	SCONJ
fnp-3806	145	21	the	the	DET
fnp-3806	145	22	combined	combined	ADJ
fnp-3806	145	23	action	action	NOUN
fnp-3806	145	24	of	of	ADP
fnp-3806	145	25	βand	βand	NOUN
fnp-3806	145	26	δ	δ	NOUN
fnp-3806	145	27	-	-	PUNCT
fnp-3806	145	28	secretases	secretase	NOUN
fnp-3806	145	29	generates	generate	VERB
fnp-3806	145	30	small	small	ADJ
fnp-3806	145	31	truncated	truncated	ADJ
fnp-3806	145	32	c	c	NOUN
fnp-3806	145	33	-	-	PUNCT
fnp-3806	145	34	teminal	teminal	ADJ
fnp-3806	145	35	peptides	peptide	NOUN
fnp-3806	145	36	at	at	ADP
fnp-3806	145	37	positions	position	NOUN
fnp-3806	145	38	42	42	NUM
fnp-3806	145	39	(	(	PUNCT
fnp-3806	145	40	aβ1	aβ1	NOUN
fnp-3806	145	41	-	-	PUNCT
fnp-3806	145	42	42	42	NUM
fnp-3806	145	43	or	or	CCONJ
fnp-3806	145	44	aβ42	aβ42	PROPN
fnp-3806	145	45	)	)	PUNCT
fnp-3806	145	46	or	or	CCONJ
fnp-3806	145	47	40	40	NUM
fnp-3806	145	48	(	(	PUNCT
fnp-3806	145	49	aβ1	aβ1	NOUN
fnp-3806	145	50	-	-	PUNCT
fnp-3806	145	51	40	40	NUM
fnp-3806	145	52	or	or	CCONJ
fnp-3806	145	53	aβ40	aβ40	PROPN
fnp-3806	145	54	)	)	PUNCT
fnp-3806	145	55	,	,	PUNCT
fnp-3806	145	56	depending	depend	VERB
fnp-3806	145	57	on	on	ADP
fnp-3806	145	58	the	the	DET
fnp-3806	145	59	thickness	thickness	NOUN
fnp-3806	145	60	of	of	ADP
fnp-3806	145	61	the	the	DET
fnp-3806	145	62	membrane	membrane	NOUN
fnp-3806	145	63	,	,	PUNCT
fnp-3806	145	64	and	and	CCONJ
fnp-3806	145	65	many	many	ADJ
fnp-3806	145	66	other	other	ADJ
fnp-3806	145	67	small	small	ADJ
fnp-3806	145	68	forms	form	NOUN
fnp-3806	145	69	are	be	AUX
fnp-3806	145	70	amyloidogenic	amyloidogenic	ADJ
fnp-3806	145	71	as	as	ADV
fnp-3806	145	72	well	well	ADV
fnp-3806	145	73	(	(	PUNCT
fnp-3806	145	74	72	72	NUM
fnp-3806	145	75	-	-	SYM
fnp-3806	145	76	75	75	NUM
fnp-3806	145	77	)	)	PUNCT
fnp-3806	145	78	.	.	PUNCT
fnp-3806	146	1	local	local	ADJ
fnp-3806	146	2	cholesterol	cholesterol	NOUN
fnp-3806	146	3	content	content	NOUN
fnp-3806	146	4	affects	affect	VERB
fnp-3806	146	5	the	the	DET
fnp-3806	146	6	various	various	ADJ
fnp-3806	146	7	secretase	secretase	NOUN
fnp-3806	146	8	activities	activity	NOUN
fnp-3806	146	9	(	(	PUNCT
fnp-3806	146	10	76	76	NUM
fnp-3806	146	11	)	)	PUNCT
fnp-3806	146	12	,	,	PUNCT
fnp-3806	146	13	including	include	VERB
fnp-3806	146	14	cholesterol	cholesterol	NOUN
fnp-3806	146	15	derived	derive	VERB
fnp-3806	146	16	from	from	ADP
fnp-3806	146	17	astrocytes	astrocyte	NOUN
fnp-3806	146	18	(	(	PUNCT
fnp-3806	146	19	77	77	NUM
fnp-3806	146	20	)	)	PUNCT
fnp-3806	146	21	.	.	PUNCT
fnp-3806	147	1	low	low	ADJ
fnp-3806	147	2	physiological	physiological	ADJ
fnp-3806	147	3	concentrations	concentration	NOUN
fnp-3806	147	4	of	of	ADP
fnp-3806	147	5	aβ	aβ	PRON
fnp-3806	147	6	seem	seem	VERB
fnp-3806	147	7	necessary	necessary	ADJ
fnp-3806	147	8	for	for	ADP
fnp-3806	147	9	long	long	ADJ
fnp-3806	147	10	-	-	PUNCT
fnp-3806	147	11	term	term	NOUN
fnp-3806	147	12	potentiation	potentiation	NOUN
fnp-3806	147	13	induction	induction	NOUN
fnp-3806	147	14	and	and	CCONJ
fnp-3806	147	15	for	for	ADP
fnp-3806	147	16	memory	memory	NOUN
fnp-3806	147	17	formation	formation	NOUN
fnp-3806	147	18	,	,	PUNCT
fnp-3806	147	19	probably	probably	ADV
fnp-3806	147	20	acting	act	VERB
fnp-3806	147	21	on	on	ADP
fnp-3806	147	22	camp	camp	NOUN
fnp-3806	147	23	and	and	CCONJ
fnp-3806	147	24	cgmp	cgmp	PROPN
fnp-3806	147	25	(	(	PUNCT
fnp-3806	147	26	78	78	NUM
fnp-3806	147	27	)	)	PUNCT
fnp-3806	147	28	.	.	PUNCT
fnp-3806	148	1	however	however	ADV
fnp-3806	148	2	,	,	PUNCT
fnp-3806	148	3	in	in	ADP
fnp-3806	148	4	aging	aging	NOUN
fnp-3806	148	5	and	and	CCONJ
fnp-3806	148	6	ad	ad	NOUN
fnp-3806	148	7	there	there	PRON
fnp-3806	148	8	is	be	VERB
fnp-3806	148	9	not	not	PART
fnp-3806	148	10	only	only	ADV
fnp-3806	148	11	abnormal	abnormal	ADJ
fnp-3806	148	12	production	production	NOUN
fnp-3806	148	13	of	of	ADP
fnp-3806	148	14	β	β	NOUN
fnp-3806	148	15	-	-	NOUN
fnp-3806	148	16	amyloid	amyloid	NOUN
fnp-3806	148	17	.	.	PUNCT
fnp-3806	149	1	aβ	aβ	PRON
fnp-3806	149	2	is	be	AUX
fnp-3806	149	3	aggregated	aggregate	VERB
fnp-3806	149	4	and	and	CCONJ
fnp-3806	149	5	accumulates	accumulate	VERB
fnp-3806	149	6	in	in	ADP
fnp-3806	149	7	the	the	DET
fnp-3806	149	8	extracellular	extracellular	ADJ
fnp-3806	149	9	space	space	NOUN
fnp-3806	149	10	due	due	ADP
fnp-3806	149	11	to	to	ADP
fnp-3806	149	12	its	its	PRON
fnp-3806	149	13	hydrofobicity	hydrofobicity	NOUN
fnp-3806	149	14	,	,	PUNCT
fnp-3806	149	15	facility	facility	NOUN
fnp-3806	149	16	for	for	ADP
fnp-3806	149	17	oligomerization	oligomerization	NOUN
fnp-3806	149	18	,	,	PUNCT
fnp-3806	149	19	and	and	CCONJ
fnp-3806	149	20	transformation	transformation	NOUN
fnp-3806	149	21	from	from	ADP
fnp-3806	149	22	an	an	DET
fnp-3806	149	23	α	α	NOUN
fnp-3806	149	24	-	-	NOUN
fnp-3806	149	25	helix	helix	NOUN
fnp-3806	149	26	to	to	ADP
fnp-3806	149	27	a	a	DET
fnp-3806	149	28	β	β	ADJ
fnp-3806	149	29	-	-	ADJ
fnp-3806	149	30	sheet	sheet	NOUN
fnp-3806	149	31	conformation	conformation	NOUN
fnp-3806	149	32	(	(	PUNCT
fnp-3806	149	33	66	66	NUM
fnp-3806	149	34	,	,	PUNCT
fnp-3806	149	35	73	73	NUM
fnp-3806	149	36	,	,	PUNCT
fnp-3806	149	37	74	74	NUM
fnp-3806	149	38	)	)	PUNCT
fnp-3806	149	39	.	.	PUNCT
fnp-3806	150	1	several	several	ADJ
fnp-3806	150	2	enzymes	enzyme	NOUN
fnp-3806	150	3	can	can	AUX
fnp-3806	150	4	degrade	degrade	VERB
fnp-3806	150	5	β	β	NOUN
fnp-3806	150	6	-	-	NOUN
fnp-3806	150	7	amyloid	amyloid	NOUN
fnp-3806	150	8	such	such	ADJ
fnp-3806	150	9	as	as	ADP
fnp-3806	150	10	neprilysin	neprilysin	NOUN
fnp-3806	150	11	,	,	PUNCT
fnp-3806	150	12	plasmin	plasmin	NOUN
fnp-3806	150	13	,	,	PUNCT
fnp-3806	150	14	endothelin	endothelin	NOUN
fnp-3806	150	15	-	-	PUNCT
fnp-3806	150	16	converting	convert	VERB
fnp-3806	150	17	enzymes	enzyme	NOUN
fnp-3806	150	18	,	,	PUNCT
fnp-3806	150	19	angiotensin	angiotensin	NOUN
fnp-3806	150	20	-	-	PUNCT
fnp-3806	150	21	converting	convert	VERB
fnp-3806	150	22	enzymes	enzyme	NOUN
fnp-3806	150	23	,	,	PUNCT
fnp-3806	150	24	insulin	insulin	NOUN
fnp-3806	150	25	-	-	PUNCT
fnp-3806	150	26	degrading	degrade	VERB
fnp-3806	150	27	enzyme	enzyme	NOUN
fnp-3806	150	28	,	,	PUNCT
fnp-3806	150	29	several	several	ADJ
fnp-3806	150	30	matrix	matrix	NOUN
fnp-3806	150	31	proteinases	proteinase	NOUN
fnp-3806	150	32	,	,	PUNCT
fnp-3806	150	33	and	and	CCONJ
fnp-3806	150	34	cathepsins	cathepsin	NOUN
fnp-3806	150	35	a	a	PRON
fnp-3806	150	36	and	and	CCONJ
fnp-3806	150	37	b	b	PROPN
fnp-3806	150	38	(	(	PUNCT
fnp-3806	150	39	79	79	NUM
fnp-3806	150	40	,	,	PUNCT
fnp-3806	150	41	80	80	NUM
fnp-3806	150	42	)	)	PUNCT
fnp-3806	150	43	.	.	PUNCT
fnp-3806	151	1	soluble	soluble	ADJ
fnp-3806	151	2	aβ	aβ	NOUN
fnp-3806	151	3	is	be	AUX
fnp-3806	151	4	drained	drain	VERB
fnp-3806	151	5	across	across	ADP
fnp-3806	151	6	the	the	DET
fnp-3806	151	7	lymphatic	lymphatic	ADJ
fnp-3806	151	8	wall	wall	NOUN
fnp-3806	151	9	,	,	PUNCT
fnp-3806	151	10	binding	bind	VERB
fnp-3806	151	11	to	to	ADP
fnp-3806	151	12	low	low	ADJ
fnp-3806	151	13	-	-	PUNCT
fnp-3806	151	14	density	density	NOUN
fnp-3806	151	15	lipoprotein	lipoprotein	ADJ
fnp-3806	151	16	receptor	receptor	NOUN
fnp-3806	151	17	-	-	PUNCT
fnp-3806	151	18	related	relate	VERB
fnp-3806	151	19	protein	protein	NOUN
fnp-3806	151	20	(	(	PUNCT
fnp-3806	151	21	lrp-1	lrp-1	NOUN
fnp-3806	151	22	)	)	PUNCT
fnp-3806	151	23	.	.	PUNCT
fnp-3806	152	1	the	the	DET
fnp-3806	152	2	expression	expression	NOUN
fnp-3806	152	3	levels	level	NOUN
fnp-3806	152	4	of	of	ADP
fnp-3806	152	5	some	some	PRON
fnp-3806	152	6	of	of	ADP
fnp-3806	152	7	these	these	DET
fnp-3806	152	8	enzymes	enzyme	NOUN
fnp-3806	152	9	and	and	CCONJ
fnp-3806	152	10	transporters	transporter	NOUN
fnp-3806	152	11	are	be	AUX
fnp-3806	152	12	reduced	reduce	VERB
fnp-3806	152	13	in	in	ADP
fnp-3806	152	14	ad	ad	NOUN
fnp-3806	152	15	(	(	PUNCT
fnp-3806	152	16	81	81	NUM
fnp-3806	152	17	-	-	PUNCT
fnp-3806	152	18	85	85	NUM
fnp-3806	152	19	)	)	PUNCT
fnp-3806	152	20	.	.	PUNCT
fnp-3806	153	1	impaired	impair	VERB
fnp-3806	153	2	lymphatic	lymphatic	ADJ
fnp-3806	153	3	drainage	drainage	NOUN
fnp-3806	153	4	and	and	CCONJ
fnp-3806	153	5	altered	alter	VERB
fnp-3806	153	6	blood	blood	NOUN
fnp-3806	153	7	vessel	vessel	NOUN
fnp-3806	153	8	walls	wall	NOUN
fnp-3806	153	9	impair	impair	VERB
fnp-3806	153	10	the	the	DET
fnp-3806	153	11	elimination	elimination	NOUN
fnp-3806	153	12	of	of	ADP
fnp-3806	153	13	soluble	soluble	ADJ
fnp-3806	153	14	β	β	NOUN
fnp-3806	153	15	-	-	NOUN
fnp-3806	153	16	amyloid	amyloid	NOUN
fnp-3806	153	17	via	via	ADP
fnp-3806	153	18	the	the	DET
fnp-3806	153	19	circulatory	circulatory	ADJ
fnp-3806	153	20	system	system	NOUN
fnp-3806	153	21	(	(	PUNCT
fnp-3806	153	22	86	86	NUM
fnp-3806	153	23	,	,	PUNCT
fnp-3806	153	24	87	87	NUM
fnp-3806	153	25	)	)	PUNCT
fnp-3806	153	26	(	(	PUNCT
fnp-3806	153	27	see	see	VERB
fnp-3806	153	28	section	section	NOUN
fnp-3806	153	29	13	13	NUM
fnp-3806	153	30	)	)	PUNCT
fnp-3806	153	31	.	.	PUNCT
fnp-3806	154	1	astrocytes	astrocyte	NOUN
fnp-3806	154	2	followed	follow	VERB
fnp-3806	154	3	by	by	ADP
fnp-3806	154	4	neurons	neuron	NOUN
fnp-3806	154	5	are	be	AUX
fnp-3806	154	6	the	the	DET
fnp-3806	154	7	main	main	ADJ
fnp-3806	154	8	source	source	NOUN
fnp-3806	154	9	of	of	ADP
fnp-3806	154	10	clusterin	clusterin	NOUN
fnp-3806	154	11	in	in	ADP
fnp-3806	154	12	brain	brain	NOUN
fnp-3806	154	13	;	;	PUNCT
fnp-3806	154	14	clusterin	clusterin	NOUN
fnp-3806	154	15	is	be	AUX
fnp-3806	154	16	then	then	ADV
fnp-3806	154	17	released	release	VERB
fnp-3806	154	18	to	to	ADP
fnp-3806	154	19	the	the	DET
fnp-3806	154	20	extracellular	extracellular	ADJ
fnp-3806	154	21	space	space	NOUN
fnp-3806	154	22	(	(	PUNCT
fnp-3806	154	23	88	88	NUM
fnp-3806	154	24	)	)	PUNCT
fnp-3806	154	25	.	.	PUNCT
fnp-3806	155	1	clusterin	clusterin	ADJ
fnp-3806	155	2	expression	expression	NOUN
fnp-3806	155	3	is	be	AUX
fnp-3806	155	4	increased	increase	VERB
fnp-3806	155	5	in	in	ADP
fnp-3806	155	6	ad	ad	NOUN
fnp-3806	155	7	(	(	PUNCT
fnp-3806	155	8	87	87	NUM
fnp-3806	155	9	,	,	PUNCT
fnp-3806	155	10	88	88	NUM
fnp-3806	155	11	)	)	PUNCT
fnp-3806	155	12	,	,	PUNCT
fnp-3806	155	13	and	and	CCONJ
fnp-3806	155	14	co	co	VERB
fnp-3806	155	15	-	-	VERB
fnp-3806	155	16	localizes	localize	VERB
fnp-3806	155	17	with	with	ADP
fnp-3806	155	18	β	β	NOUN
fnp-3806	155	19	-	-	ADJ
fnp-3806	155	20	amyloid	amyloid	ADJ
fnp-3806	155	21	deposits	deposit	NOUN
fnp-3806	155	22	(	(	PUNCT
fnp-3806	155	23	91	91	NUM
fnp-3806	155	24	)	)	PUNCT
fnp-3806	155	25	,	,	PUNCT
fnp-3806	155	26	more	more	ADV
fnp-3806	155	27	specifically	specifically	ADV
fnp-3806	155	28	with	with	ADP
fnp-3806	155	29	aβ1	aβ1	NOUN
fnp-3806	155	30	-	-	SYM
fnp-3806	155	31	40	40	NUM
fnp-3806	155	32	(	(	PUNCT
fnp-3806	155	33	92	92	NUM
fnp-3806	155	34	)	)	PUNCT
fnp-3806	155	35	.	.	PUNCT
fnp-3806	156	1	clusterin	clusterin	PROPN
fnp-3806	156	2	may	may	AUX
fnp-3806	156	3	act	act	VERB
fnp-3806	156	4	as	as	ADP
fnp-3806	156	5	an	an	DET
fnp-3806	156	6	extracellular	extracellular	ADJ
fnp-3806	156	7	chaperone	chaperone	NOUN
fnp-3806	156	8	(	(	PUNCT
fnp-3806	156	9	93	93	NUM
fnp-3806	156	10	)	)	PUNCT
fnp-3806	156	11	and	and	CCONJ
fnp-3806	156	12	it	it	PRON
fnp-3806	156	13	contributes	contribute	VERB
fnp-3806	156	14	to	to	ADP
fnp-3806	156	15	early	early	ADJ
fnp-3806	156	16	stages	stage	NOUN
fnp-3806	156	17	of	of	ADP
fnp-3806	156	18	β	β	NOUN
fnp-3806	156	19	-	-	ADJ
fnp-3806	156	20	amyloid	amyloid	ADJ
fnp-3806	156	21	plaque	plaque	NOUN
fnp-3806	156	22	pathology	pathology	NOUN
fnp-3806	156	23	(	(	PUNCT
fnp-3806	156	24	94	94	NUM
fnp-3806	156	25	)	)	PUNCT
fnp-3806	156	26	.	.	PUNCT
fnp-3806	157	1	in	in	ADP
fnp-3806	157	2	addition	addition	NOUN
fnp-3806	157	3	to	to	ADP
fnp-3806	157	4	being	be	AUX
fnp-3806	157	5	involved	involve	VERB
fnp-3806	157	6	in	in	ADP
fnp-3806	157	7	aβ	aβ	DET
fnp-3806	157	8	aggregation	aggregation	NOUN
fnp-3806	157	9	and	and	CCONJ
fnp-3806	157	10	clearance	clearance	NOUN
fnp-3806	157	11	and	and	CCONJ
fnp-3806	157	12	in	in	ADP
fnp-3806	157	13	the	the	DET
fnp-3806	157	14	modulation	modulation	NOUN
fnp-3806	157	15	of	of	ADP
fnp-3806	157	16	aβ	aβ	NOUN
fnp-3806	157	17	transport	transport	NOUN
fnp-3806	157	18	across	across	ADP
fnp-3806	157	19	the	the	DET
fnp-3806	157	20	blood	blood	NOUN
fnp-3806	157	21	brain	brain	NOUN
fnp-3806	157	22	barrier	barrier	NOUN
fnp-3806	157	23	(	(	PUNCT
fnp-3806	157	24	bbb	bbb	PROPN
fnp-3806	157	25	)	)	PUNCT
fnp-3806	157	26	(	(	PUNCT
fnp-3806	157	27	95	95	NUM
fnp-3806	157	28	-	-	SYM
fnp-3806	157	29	97	97	NUM
fnp-3806	157	30	)	)	PUNCT
fnp-3806	157	31	,	,	PUNCT
fnp-3806	157	32	clusterin	clusterin	NOUN
fnp-3806	157	33	is	be	AUX
fnp-3806	157	34	also	also	ADV
fnp-3806	157	35	known	know	VERB
fnp-3806	157	36	to	to	PART
fnp-3806	157	37	reduce	reduce	VERB
fnp-3806	157	38	aβ	aβ	DET
fnp-3806	157	39	toxicity	toxicity	NOUN
fnp-3806	157	40	(	(	PUNCT
fnp-3806	157	41	98	98	NUM
fnp-3806	157	42	,	,	PUNCT
fnp-3806	157	43	99	99	NUM
fnp-3806	157	44	)	)	PUNCT
fnp-3806	157	45	.	.	PUNCT
fnp-3806	158	1	in	in	ADP
fnp-3806	158	2	addition	addition	NOUN
fnp-3806	158	3	,	,	PUNCT
fnp-3806	158	4	clusterin	clusterin	NOUN
fnp-3806	158	5	seems	seem	VERB
fnp-3806	158	6	to	to	PART
fnp-3806	158	7	interact	interact	VERB
fnp-3806	158	8	with	with	ADP
fnp-3806	158	9	bridging	bridge	VERB
fnp-3806	158	10	integrator	integrator	NOUN
fnp-3806	158	11	protein	protein	NOUN
fnp-3806	158	12	1	1	NUM
fnp-3806	158	13	(	(	PUNCT
fnp-3806	158	14	bin1	bin1	PROPN
fnp-3806	158	15	)	)	PUNCT
fnp-3806	158	16	and	and	CCONJ
fnp-3806	158	17	tau	tau	PROPN
fnp-3806	158	18	(	(	PUNCT
fnp-3806	158	19	100	100	NUM
fnp-3806	158	20	)	)	PUNCT
fnp-3806	158	21	.	.	PUNCT
fnp-3806	159	1	the	the	PRON
fnp-3806	159	2	main	main	ADJ
fnp-3806	159	3	β	β	NOUN
fnp-3806	159	4	-	-	NOUN
fnp-3806	159	5	amyloid	amyloid	NOUN
fnp-3806	159	6	that	that	PRON
fnp-3806	159	7	circulates	circulate	VERB
fnp-3806	159	8	in	in	ADP
fnp-3806	159	9	brain	brain	NOUN
fnp-3806	159	10	interstitial	interstitial	ADJ
fnp-3806	159	11	fluid	fluid	NOUN
fnp-3806	159	12	and	and	CCONJ
fnp-3806	159	13	cerebrospinal	cerebrospinal	ADJ
fnp-3806	159	14	fluid	fluid	NOUN
fnp-3806	159	15	(	(	PUNCT
fnp-3806	159	16	csf	csf	NOUN
fnp-3806	159	17	)	)	PUNCT
fnp-3806	159	18	is	be	AUX
fnp-3806	159	19	soluble	soluble	ADJ
fnp-3806	159	20	aβ40	aβ40	PROPN
fnp-3806	159	21	.	.	PUNCT
fnp-3806	160	1	β	β	X
fnp-3806	160	2	-	-	ADJ
fnp-3806	160	3	amyloid	amyloid	ADJ
fnp-3806	160	4	deposits	deposit	NOUN
fnp-3806	160	5	in	in	ADP
fnp-3806	160	6	ad	ad	NOUN
fnp-3806	160	7	are	be	AUX
fnp-3806	160	8	categorized	categorize	VERB
fnp-3806	160	9	as	as	ADP
fnp-3806	160	10	primitive	primitive	ADJ
fnp-3806	160	11	or	or	CCONJ
fnp-3806	160	12	immature	immature	ADJ
fnp-3806	160	13	plaques	plaque	NOUN
fnp-3806	160	14	,	,	PUNCT
fnp-3806	160	15	mature	mature	ADJ
fnp-3806	160	16	or	or	CCONJ
fnp-3806	160	17	neuritic	neuritic	ADJ
fnp-3806	160	18	plaques	plaque	NOUN
fnp-3806	160	19	(	(	PUNCT
fnp-3806	160	20	classical	classical	ADJ
fnp-3806	160	21	sps	sps	NOUN
fnp-3806	160	22	)	)	PUNCT
fnp-3806	160	23	,	,	PUNCT
fnp-3806	160	24	compact	compact	ADJ
fnp-3806	160	25	or	or	CCONJ
fnp-3806	160	26	burned	burn	VERB
fnp-3806	160	27	-	-	PUNCT
fnp-3806	160	28	out	out	NOUN
fnp-3806	160	29	,	,	PUNCT
fnp-3806	160	30	cotton	cotton	NOUN
fnp-3806	160	31	-	-	PUNCT
fnp-3806	160	32	wool	wool	NOUN
fnp-3806	160	33	plaques	plaque	NOUN
fnp-3806	160	34	,	,	PUNCT
fnp-3806	160	35	diffuse	diffuse	NOUN
fnp-3806	160	36	plaques	plaque	NOUN
fnp-3806	160	37	,	,	PUNCT
fnp-3806	160	38	subpial	subpial	ADJ
fnp-3806	160	39	β	β	NOUN
fnp-3806	160	40	-	-	ADJ
fnp-3806	160	41	amyloid	amyloid	ADJ
fnp-3806	160	42	deposits	deposit	NOUN
fnp-3806	160	43	,	,	PUNCT
fnp-3806	160	44	β	β	NOUN
fnp-3806	160	45	-	-	NOUN
fnp-3806	160	46	amyloid	amyloid	ADJ
fnp-3806	160	47	angiopathy	angiopathy	NOUN
fnp-3806	160	48	,	,	PUNCT
fnp-3806	160	49	and	and	CCONJ
fnp-3806	160	50	perivascular	perivascular	ADJ
fnp-3806	160	51	plaques	plaque	NOUN
fnp-3806	160	52	(	(	PUNCT
fnp-3806	160	53	dyshoric	dyshoric	NOUN
fnp-3806	160	54	angiopathy	angiopathy	NOUN
fnp-3806	160	55	)	)	PUNCT
fnp-3806	160	56	(	(	PUNCT
fnp-3806	160	57	figure	figure	NOUN
fnp-3806	160	58	4	4	NUM
fnp-3806	160	59	)	)	PUNCT
fnp-3806	160	60	.	.	PUNCT
fnp-3806	161	1	β	β	X
fnp-3806	161	2	-	-	PUNCT
fnp-3806	161	3	amyloid	amyloid	NOUN
fnp-3806	161	4	can	can	AUX
fnp-3806	161	5	also	also	ADV
fnp-3806	161	6	be	be	AUX
fnp-3806	161	7	found	find	VERB
fnp-3806	161	8	in	in	ADP
fnp-3806	161	9	the	the	DET
fnp-3806	161	10	cytoplasm	cytoplasm	NOUN
fnp-3806	161	11	of	of	ADP
fnp-3806	161	12	neurons	neuron	NOUN
fnp-3806	161	13	,	,	PUNCT
fnp-3806	161	14	and	and	CCONJ
fnp-3806	161	15	in	in	ADP
fnp-3806	161	16	astrocytes	astrocyte	NOUN
fnp-3806	161	17	at	at	ADP
fnp-3806	161	18	the	the	DET
fnp-3806	161	19	periphery	periphery	NOUN
fnp-3806	161	20	of	of	ADP
fnp-3806	161	21	sps	sps	PROPN
fnp-3806	161	22	.	.	PUNCT
fnp-3806	162	1	β	β	X
fnp-3806	162	2	-	-	PUNCT
fnp-3806	162	3	amyloid	amyloid	NOUN
fnp-3806	162	4	is	be	AUX
fnp-3806	162	5	composed	compose	VERB
fnp-3806	162	6	of	of	ADP
fnp-3806	162	7	a	a	DET
fnp-3806	162	8	mixture	mixture	NOUN
fnp-3806	162	9	of	of	ADP
fnp-3806	162	10	peptides	peptide	NOUN
fnp-3806	162	11	of	of	ADP
fnp-3806	162	12	different	different	ADJ
fnp-3806	162	13	molecular	molecular	ADJ
fnp-3806	162	14	weight	weight	NOUN
fnp-3806	162	15	:	:	PUNCT
fnp-3806	162	16	aβ40	aβ40	PROPN
fnp-3806	162	17	and	and	CCONJ
fnp-3806	162	18	aβ42	aβ42	PROPN
fnp-3806	162	19	are	be	AUX
fnp-3806	162	20	predominant	predominant	ADJ
fnp-3806	162	21	in	in	ADP
fnp-3806	162	22	sps	sps	PROPN
fnp-3806	162	23	,	,	PUNCT
fnp-3806	162	24	while	while	SCONJ
fnp-3806	162	25	aβ40	aβ40	PROPN
fnp-3806	162	26	is	be	AUX
fnp-3806	162	27	mainly	mainly	ADV
fnp-3806	162	28	located	locate	VERB
fnp-3806	162	29	at	at	ADP
fnp-3806	162	30	the	the	DET
fnp-3806	162	31	core	core	NOUN
fnp-3806	162	32	of	of	ADP
fnp-3806	162	33	sps	sps	PROPN
fnp-3806	162	34	and	and	CCONJ
fnp-3806	162	35	aβ42	aβ42	PROPN
fnp-3806	162	36	at	at	ADP
fnp-3806	162	37	their	their	PRON
fnp-3806	162	38	periphery	periphery	NOUN
fnp-3806	162	39	.	.	PUNCT
fnp-3806	163	1	diffuse	diffuse	VERB
fnp-3806	163	2	plaques	plaque	NOUN
fnp-3806	163	3	contain	contain	VERB
fnp-3806	163	4	aβ42	aβ42	PROPN
fnp-3806	163	5	and	and	CCONJ
fnp-3806	163	6	truncated	truncated	ADJ
fnp-3806	163	7	forms	form	NOUN
fnp-3806	163	8	aβ17	aβ17	PROPN
fnp-3806	163	9	-	-	PUNCT
fnp-3806	163	10	42	42	NUM
fnp-3806	163	11	.	.	PUNCT
fnp-3806	164	1	subpial	subpial	ADJ
fnp-3806	164	2	β	β	NOUN
fnp-3806	164	3	-	-	ADJ
fnp-3806	164	4	amyloid	amyloid	ADJ
fnp-3806	164	5	deposits	deposit	NOUN
fnp-3806	164	6	are	be	AUX
fnp-3806	164	7	mainly	mainly	ADV
fnp-3806	164	8	composed	compose	VERB
fnp-3806	164	9	of	of	ADP
fnp-3806	164	10	amino	amino	NOUN
fnp-3806	164	11	-	-	PUNCT
fnp-3806	164	12	terminal	terminal	ADJ
fnp-3806	164	13	truncated	truncate	VERB
fnp-3806	164	14	species	specie	NOUN
fnp-3806	164	15	.	.	PUNCT
fnp-3806	165	1	β	β	X
fnp-3806	165	2	-	-	PUNCT
fnp-3806	165	3	amyloid	amyloid	ADJ
fnp-3806	165	4	species	specie	NOUN
fnp-3806	165	5	have	have	VERB
fnp-3806	165	6	different	different	ADJ
fnp-3806	165	7	aggregation	aggregation	NOUN
fnp-3806	165	8	properties	property	NOUN
fnp-3806	165	9	.	.	PUNCT
fnp-3806	166	1	n	n	CCONJ
fnp-3806	166	2	-	-	PUNCT
fnp-3806	166	3	terminal	terminal	NOUN
fnp-3806	166	4	truncated	truncate	VERB
fnp-3806	166	5	aβ	aβ	NOUN
fnp-3806	166	6	with	with	ADP
fnp-3806	166	7	pyroglutamate	pyroglutamate	NOUN
fnp-3806	166	8	modification	modification	NOUN
fnp-3806	166	9	at	at	ADP
fnp-3806	166	10	position	position	NOUN
fnp-3806	166	11	3	3	NUM
fnp-3806	166	12	and	and	CCONJ
fnp-3806	166	13	aβ	aβ	PRON
fnp-3806	166	14	phosphorylated	phosphorylate	VERB
fnp-3806	166	15	at	at	ADP
fnp-3806	166	16	serine	serine	NOUN
fnp-3806	166	17	8	8	NUM
fnp-3806	166	18	show	show	NOUN
fnp-3806	166	19	enhanced	enhance	VERB
fnp-3806	166	20	aggregation	aggregation	NOUN
fnp-3806	166	21	into	into	ADP
fnp-3806	166	22	oligomers	oligomer	NOUN
fnp-3806	166	23	and	and	CCONJ
fnp-3806	166	24	fibrils	fibril	NOUN
fnp-3806	166	25	.	.	PUNCT
fnp-3806	167	1	these	these	DET
fnp-3806	167	2	forms	form	NOUN
fnp-3806	167	3	appear	appear	VERB
fnp-3806	167	4	at	at	ADP
fnp-3806	167	5	late	late	ADJ
fnp-3806	167	6	stages	stage	NOUN
fnp-3806	167	7	(	(	PUNCT
fnp-3806	167	8	biochemical	biochemical	ADJ
fnp-3806	167	9	stages	stage	NOUN
fnp-3806	167	10	2	2	NUM
fnp-3806	167	11	and	and	CCONJ
fnp-3806	167	12	3	3	NUM
fnp-3806	167	13	)	)	PUNCT
fnp-3806	167	14	of	of	ADP
fnp-3806	167	15	β	β	NOUN
fnp-3806	167	16	-	-	ADJ
fnp-3806	167	17	amyloid	amyloid	ADJ
fnp-3806	167	18	formation	formation	NOUN
fnp-3806	167	19	,	,	PUNCT
fnp-3806	167	20	whereas	whereas	SCONJ
fnp-3806	167	21	soluble	soluble	ADJ
fnp-3806	167	22	and	and	CCONJ
fnp-3806	167	23	insoluble	insoluble	ADJ
fnp-3806	167	24	aggregates	aggregate	NOUN
fnp-3806	167	25	composed	compose	VERB
fnp-3806	167	26	of	of	ADP
fnp-3806	167	27	non	non	ADJ
fnp-3806	167	28	-	-	ADJ
fnp-3806	167	29	modified	modified	ADJ
fnp-3806	167	30	aβ	aβ	NOUN
fnp-3806	167	31	are	be	AUX
fnp-3806	167	32	found	find	VERB
fnp-3806	167	33	at	at	ADP
fnp-3806	167	34	early	early	ADJ
fnp-3806	167	35	stages	stage	NOUN
fnp-3806	167	36	(	(	PUNCT
fnp-3806	167	37	stage	stage	NOUN
fnp-3806	167	38	1	1	NUM
fnp-3806	167	39	)	)	PUNCT
fnp-3806	167	40	(	(	PUNCT
fnp-3806	167	41	101	101	NUM
fnp-3806	167	42	,	,	PUNCT
fnp-3806	167	43	102	102	NUM
fnp-3806	167	44	)	)	PUNCT
fnp-3806	167	45	.	.	PUNCT
fnp-3806	168	1	figure	figure	VERB
fnp-3806	168	2	4	4	NUM
fnp-3806	168	3	:	:	PUNCT
fnp-3806	168	4	β	β	NOUN
fnp-3806	168	5	-	-	NOUN
fnp-3806	168	6	amyloid	amyloid	ADJ
fnp-3806	168	7	deposits	deposit	NOUN
fnp-3806	168	8	in	in	ADP
fnp-3806	168	9	the	the	DET
fnp-3806	168	10	temporal	temporal	ADJ
fnp-3806	168	11	cortex	cortex	NOUN
fnp-3806	168	12	.	.	PUNCT
fnp-3806	169	1	paraffin	paraffin	NOUN
fnp-3806	169	2	section	section	NOUN
fnp-3806	169	3	,	,	PUNCT
fnp-3806	169	4	β	β	NOUN
fnp-3806	169	5	-	-	NOUN
fnp-3806	169	6	amyloid	amyloid	NOUN
fnp-3806	169	7	immunohistochemistry	immunohistochemistry	NOUN
fnp-3806	169	8	,	,	PUNCT
fnp-3806	169	9	slight	slight	ADJ
fnp-3806	169	10	hematoxylin	hematoxylin	PROPN
fnp-3806	169	11	counterstaing	counterstaing	NOUN
fnp-3806	169	12	,	,	PUNCT
fnp-3806	169	13	bar	bar	NOUN
fnp-3806	169	14	=	=	SYM
fnp-3806	169	15	50μm	50μm	NOUN
fnp-3806	169	16	.	.	PUNCT
fnp-3806	170	1	soluble	soluble	ADJ
fnp-3806	170	2	β	β	NOUN
fnp-3806	170	3	-	-	ADJ
fnp-3806	170	4	amyloid	amyloid	ADJ
fnp-3806	170	5	oligomers	oligomer	NOUN
fnp-3806	170	6	(	(	PUNCT
fnp-3806	170	7	aβos	aβos	PROPN
fnp-3806	170	8	)	)	PUNCT
fnp-3806	170	9	and	and	CCONJ
fnp-3806	170	10	amyloid	amyloid	NOUN
fnp-3806	170	11	-	-	PUNCT
fnp-3806	170	12	β	β	NOUN
fnp-3806	170	13	derived	derive	VERB
fnp-3806	170	14	diffusible	diffusible	ADJ
fnp-3806	170	15	ligands	ligand	NOUN
fnp-3806	170	16	(	(	PUNCT
fnp-3806	170	17	addls	addls	PROPN
fnp-3806	170	18	)	)	PUNCT
fnp-3806	170	19	,	,	PUNCT
fnp-3806	170	20	acting	act	VERB
fnp-3806	170	21	through	through	ADP
fnp-3806	170	22	specific	specific	ADJ
fnp-3806	170	23	cell	cell	NOUN
fnp-3806	170	24	surface	surface	NOUN
fnp-3806	170	25	receptors	receptor	NOUN
fnp-3806	170	26	rather	rather	ADV
fnp-3806	170	27	than	than	ADP
fnp-3806	170	28	fibrils	fibril	NOUN
fnp-3806	170	29	,	,	PUNCT
fnp-3806	170	30	are	be	AUX
fnp-3806	170	31	toxic	toxic	ADJ
fnp-3806	170	32	and	and	CCONJ
fnp-3806	170	33	cause	cause	VERB
fnp-3806	170	34	neurodegeneration	neurodegeneration	NOUN
fnp-3806	170	35	(	(	PUNCT
fnp-3806	170	36	103	103	NUM
fnp-3806	170	37	-	-	SYM
fnp-3806	170	38	115	115	NUM
fnp-3806	170	39	)	)	PUNCT
fnp-3806	170	40	.	.	PUNCT
fnp-3806	171	1	high	high	ADJ
fnp-3806	171	2	-	-	PUNCT
fnp-3806	171	3	molecular	molecular	NOUN
fnp-3806	171	4	-	-	PUNCT
fnp-3806	171	5	weight	weight	NOUN
fnp-3806	171	6	β	β	NOUN
fnp-3806	171	7	-	-	ADJ
fnp-3806	171	8	amyloid	amyloid	ADJ
fnp-3806	171	9	oligomer	oligomer	ADJ
fnp-3806	171	10	levels	level	NOUN
fnp-3806	171	11	are	be	AUX
fnp-3806	171	12	elevated	elevate	VERB
fnp-3806	171	13	in	in	ADP
fnp-3806	171	14	the	the	DET
fnp-3806	171	15	csf	csf	NOUN
fnp-3806	171	16	in	in	ADP
fnp-3806	171	17	ad	ad	NOUN
fnp-3806	171	18	(	(	PUNCT
fnp-3806	171	19	116	116	NUM
fnp-3806	171	20	)	)	PUNCT
fnp-3806	171	21	.	.	PUNCT
fnp-3806	172	1	yet	yet	ADV
fnp-3806	172	2	in	in	ADP
fnp-3806	172	3	the	the	DET
fnp-3806	172	4	cerebral	cerebral	ADJ
fnp-3806	172	5	tissue	tissue	NOUN
fnp-3806	172	6	,	,	PUNCT
fnp-3806	172	7	the	the	DET
fnp-3806	172	8	ratio	ratio	NOUN
fnp-3806	172	9	of	of	ADP
fnp-3806	172	10	aβ	aβ	PRON
fnp-3806	172	11	oligomer	oligomer	ADJ
fnp-3806	172	12	levels	level	NOUN
fnp-3806	172	13	to	to	ADP
fnp-3806	172	14	plaque	plaque	NOUN
fnp-3806	172	15	density	density	NOUN
fnp-3806	172	16	distinguishes	distinguish	VERB
fnp-3806	172	17	demented	demente	VERB
fnp-3806	172	18	from	from	ADP
fnp-3806	172	19	non	non	ADJ
fnp-3806	172	20	-	-	ADJ
fnp-3806	172	21	demented	demented	ADJ
fnp-3806	172	22	patients	patient	NOUN
fnp-3806	172	23	(	(	PUNCT
fnp-3806	172	24	117	117	NUM
fnp-3806	172	25	)	)	PUNCT
fnp-3806	172	26	.	.	PUNCT
fnp-3806	173	1	several	several	ADJ
fnp-3806	173	2	membrane	membrane	NOUN
fnp-3806	173	3	receptors	receptor	NOUN
fnp-3806	173	4	can	can	AUX
fnp-3806	173	5	bind	bind	VERB
fnp-3806	173	6	to	to	ADP
fnp-3806	173	7	aβ	aβ	NOUN
fnp-3806	173	8	oligomers	oligomer	NOUN
fnp-3806	173	9	.	.	PUNCT
fnp-3806	174	1	these	these	DET
fnp-3806	174	2	receptors	receptor	NOUN
fnp-3806	174	3	include	include	VERB
fnp-3806	174	4	the	the	DET
fnp-3806	174	5	cellular	cellular	ADJ
fnp-3806	174	6	prion	prion	NOUN
fnp-3806	174	7	protein	protein	NOUN
fnp-3806	174	8	(	(	PUNCT
fnp-3806	174	9	prpc	prpc	NOUN
fnp-3806	174	10	)	)	PUNCT
fnp-3806	174	11	;	;	PUNCT
fnp-3806	174	12	the	the	DET
fnp-3806	174	13	α7	α7	NOUN
fnp-3806	174	14	nicotinic	nicotinic	ADJ
fnp-3806	174	15	acetylcholine	acetylcholine	NOUN
fnp-3806	174	16	receptor	receptor	NOUN
fnp-3806	174	17	(	(	PUNCT
fnp-3806	174	18	α7nachr	α7nachr	NOUN
fnp-3806	174	19	)	)	PUNCT
fnp-3806	174	20	;	;	PUNCT
fnp-3806	174	21	fcγ	fcγ	NOUN
fnp-3806	174	22	receptor	receptor	NOUN
fnp-3806	174	23	ii	ii	PROPN
fnp-3806	174	24	-	-	PUNCT
fnp-3806	174	25	b	b	PROPN
fnp-3806	174	26	(	(	PUNCT
fnp-3806	174	27	fcγriib	fcγriib	NOUN
fnp-3806	174	28	)	)	PUNCT
fnp-3806	174	29	;	;	PUNCT
fnp-3806	174	30	the	the	DET
fnp-3806	174	31	p75	p75	ADJ
fnp-3806	174	32	neurotrophin	neurotrophin	ADJ
fnp-3806	174	33	receptor	receptor	NOUN
fnp-3806	174	34	(	(	PUNCT
fnp-3806	174	35	p75ntr	p75ntr	PROPN
fnp-3806	174	36	)	)	PUNCT
fnp-3806	174	37	;	;	PUNCT
fnp-3806	174	38	the	the	DET
fnp-3806	174	39	paired	pair	VERB
fnp-3806	174	40	immunoglobulin	immunoglobulin	NOUN
fnp-3806	174	41	-	-	PUNCT
fnp-3806	174	42	like	like	ADJ
fnp-3806	174	43	receptor	receptor	NOUN
fnp-3806	174	44	b	b	PROPN
fnp-3806	174	45	(	(	PUNCT
fnp-3806	174	46	pirb	pirb	NOUN
fnp-3806	174	47	)	)	PUNCT
fnp-3806	174	48	;	;	PUNCT
fnp-3806	174	49	the	the	DET
fnp-3806	174	50	pirb	pirb	NOUN
fnp-3806	174	51	human	human	ADJ
fnp-3806	174	52	orthologue	orthologue	NOUN
fnp-3806	174	53	receptor	receptor	NOUN
fnp-3806	174	54	(	(	PUNCT
fnp-3806	174	55	lilrb2	lilrb2	PROPN
fnp-3806	174	56	)	)	PUNCT
fnp-3806	174	57	;	;	PUNCT
fnp-3806	174	58	the	the	DET
fnp-3806	174	59	β	β	ADJ
fnp-3806	174	60	-	-	ADJ
fnp-3806	174	61	adrenergic	adrenergic	ADJ
fnp-3806	174	62	receptors	receptor	NOUN
fnp-3806	174	63	(	(	PUNCT
fnp-3806	174	64	β	β	NOUN
fnp-3806	174	65	-	-	NOUN
fnp-3806	174	66	ars	ar	NOUN
fnp-3806	174	67	)	)	PUNCT
fnp-3806	174	68	;	;	PUNCT
fnp-3806	174	69	and	and	CCONJ
fnp-3806	174	70	the	the	DET
fnp-3806	174	71	eph	eph	NOUN
fnp-3806	174	72	receptors	receptor	NOUN
fnp-3806	174	73	(	(	PUNCT
fnp-3806	174	74	118	118	NUM
fnp-3806	174	75	)	)	PUNCT
fnp-3806	174	76	,	,	PUNCT
fnp-3806	174	77	among	among	ADP
fnp-3806	174	78	others	other	NOUN
fnp-3806	174	79	.	.	PUNCT
fnp-3806	175	1	prpc	prpc	NOUN
fnp-3806	175	2	is	be	AUX
fnp-3806	175	3	one	one	NUM
fnp-3806	175	4	of	of	ADP
fnp-3806	175	5	the	the	DET
fnp-3806	175	6	binding	bind	VERB
fnp-3806	175	7	partners	partner	NOUN
fnp-3806	175	8	for	for	ADP
fnp-3806	175	9	aβ	aβ	X
fnp-3806	175	10	oligomers	oligomer	NOUN
fnp-3806	175	11	(	(	PUNCT
fnp-3806	175	12	119	119	NUM
fnp-3806	175	13	-	-	SYM
fnp-3806	175	14	125	125	NUM
fnp-3806	175	15	)	)	PUNCT
fnp-3806	175	16	,	,	PUNCT
fnp-3806	175	17	and	and	CCONJ
fnp-3806	175	18	prpc	prpc	NOUN
fnp-3806	175	19	mediates	mediate	NOUN
fnp-3806	175	20	impairment	impairment	NOUN
fnp-3806	175	21	of	of	ADP
fnp-3806	175	22	synaptic	synaptic	ADJ
fnp-3806	175	23	plasticity	plasticity	NOUN
fnp-3806	175	24	by	by	ADP
fnp-3806	175	25	aβ	aβ	X
fnp-3806	175	26	oligomers	oligomer	NOUN
fnp-3806	175	27	(	(	PUNCT
fnp-3806	175	28	124	124	NUM
fnp-3806	175	29	)	)	PUNCT
fnp-3806	175	30	.	.	PUNCT
fnp-3806	176	1	besides	besides	SCONJ
fnp-3806	176	2	β	β	NOUN
fnp-3806	176	3	-	-	ADJ
fnp-3806	176	4	amyloid	amyloid	ADJ
fnp-3806	176	5	species	specie	NOUN
fnp-3806	176	6	,	,	PUNCT
fnp-3806	176	7	several	several	ADJ
fnp-3806	176	8	molecules	molecule	NOUN
fnp-3806	176	9	are	be	AUX
fnp-3806	176	10	also	also	ADV
fnp-3806	176	11	components	component	NOUN
fnp-3806	176	12	of	of	ADP
fnp-3806	176	13	sps	sps	NOUN
fnp-3806	176	14	including	include	VERB
fnp-3806	176	15	metal	metal	NOUN
fnp-3806	176	16	ions	ion	NOUN
fnp-3806	176	17	,	,	PUNCT
fnp-3806	176	18	lipids	lipid	NOUN
fnp-3806	176	19	,	,	PUNCT
fnp-3806	176	20	mucopolysaccharides	mucopolysaccharide	NOUN
fnp-3806	176	21	,	,	PUNCT
fnp-3806	176	22	immunoglobulins	immunoglobulin	NOUN
fnp-3806	176	23	,	,	PUNCT
fnp-3806	176	24	members	member	NOUN
fnp-3806	176	25	of	of	ADP
fnp-3806	176	26	the	the	DET
fnp-3806	176	27	complement	complement	NOUN
fnp-3806	176	28	system	system	NOUN
fnp-3806	176	29	,	,	PUNCT
fnp-3806	176	30	molecules	molecule	NOUN
fnp-3806	176	31	linked	link	VERB
fnp-3806	176	32	to	to	ADP
fnp-3806	176	33	lipid	lipid	ADJ
fnp-3806	176	34	metabolism	metabolism	NOUN
fnp-3806	176	35	and	and	CCONJ
fnp-3806	176	36	lipid	lipid	NOUN
fnp-3806	176	37	transport	transport	NOUN
fnp-3806	176	38	,	,	PUNCT
fnp-3806	176	39	blood	blood	NOUN
fnp-3806	176	40	coagulation	coagulation	NOUN
fnp-3806	176	41	/	/	SYM
fnp-3806	176	42	haemostasis	haemostasis	NOUN
fnp-3806	176	43	factors	factor	NOUN
fnp-3806	176	44	,	,	PUNCT
fnp-3806	176	45	proteins	protein	NOUN
fnp-3806	176	46	linked	link	VERB
fnp-3806	176	47	to	to	ADP
fnp-3806	176	48	metabolism	metabolism	NOUN
fnp-3806	176	49	and	and	CCONJ
fnp-3806	176	50	molecular	molecular	ADJ
fnp-3806	176	51	transport	transport	NOUN
fnp-3806	176	52	,	,	PUNCT
fnp-3806	176	53	neural	neural	ADJ
fnp-3806	176	54	,	,	PUNCT
fnp-3806	176	55	cell	cell	NOUN
fnp-3806	176	56	adhesion	adhesion	NOUN
fnp-3806	176	57	and	and	CCONJ
fnp-3806	176	58	extracellular	extracellular	ADJ
fnp-3806	176	59	matrix	matrix	NOUN
fnp-3806	176	60	proteins	protein	NOUN
fnp-3806	176	61	,	,	PUNCT
fnp-3806	176	62	proteoglycans	proteoglycan	NOUN
fnp-3806	176	63	,	,	PUNCT
fnp-3806	176	64	and	and	CCONJ
fnp-3806	176	65	other	other	ADJ
fnp-3806	176	66	cellular	cellular	ADJ
fnp-3806	176	67	proteins	protein	NOUN
fnp-3806	176	68	(	(	PUNCT
fnp-3806	176	69	126	126	NUM
fnp-3806	176	70	,	,	PUNCT
fnp-3806	176	71	127	127	NUM
fnp-3806	176	72	)	)	PUNCT
fnp-3806	176	73	.	.	PUNCT
fnp-3806	177	1	the	the	DET
fnp-3806	177	2	large	large	ADJ
fnp-3806	177	3	amount	amount	NOUN
fnp-3806	177	4	of	of	ADP
fnp-3806	177	5	proteins	protein	NOUN
fnp-3806	177	6	in	in	ADP
fnp-3806	177	7	sps	sps	PROPN
fnp-3806	177	8	is	be	AUX
fnp-3806	177	9	likely	likely	ADJ
fnp-3806	177	10	the	the	DET
fnp-3806	177	11	consequence	consequence	NOUN
fnp-3806	177	12	of	of	ADP
fnp-3806	177	13	co	co	NOUN
fnp-3806	177	14	-	-	NOUN
fnp-3806	177	15	aggregation	aggregation	NOUN
fnp-3806	177	16	and	and	CCONJ
fnp-3806	177	17	alteration	alteration	NOUN
fnp-3806	177	18	of	of	ADP
fnp-3806	177	19	associated	associated	ADJ
fnp-3806	177	20	biochemical	biochemical	ADJ
fnp-3806	177	21	processes	process	NOUN
fnp-3806	177	22	by	by	ADP
fnp-3806	177	23	which	which	PRON
fnp-3806	177	24	β	β	NOUN
fnp-3806	177	25	-	-	NOUN
fnp-3806	177	26	amyloid	amyloid	ADJ
fnp-3806	177	27	formation	formation	NOUN
fnp-3806	177	28	leads	lead	VERB
fnp-3806	177	29	to	to	ADP
fnp-3806	177	30	neurodegeneration	neurodegeneration	NOUN
fnp-3806	177	31	(	(	PUNCT
fnp-3806	177	32	127	127	NUM
fnp-3806	177	33	)	)	PUNCT
fnp-3806	177	34	.	.	PUNCT
fnp-3806	178	1	moreover	moreover	ADV
fnp-3806	178	2	,	,	PUNCT
fnp-3806	178	3	prpc	prpc	ADJ
fnp-3806	178	4	co	co	VERB
fnp-3806	178	5	-	-	VERB
fnp-3806	178	6	localizes	localize	VERB
fnp-3806	178	7	with	with	ADP
fnp-3806	178	8	aβ	aβ	PRON
fnp-3806	178	9	in	in	ADP
fnp-3806	178	10	sps	sps	PROPN
fnp-3806	178	11	(	(	PUNCT
fnp-3806	178	12	128	128	NUM
fnp-3806	178	13	)	)	PUNCT
fnp-3806	178	14	.	.	PUNCT
fnp-3806	179	1	β	β	X
fnp-3806	179	2	-	-	PUNCT
fnp-3806	179	3	amyloid	amyloid	ADJ
fnp-3806	179	4	plaques	plaque	NOUN
fnp-3806	179	5	are	be	AUX
fnp-3806	179	6	associated	associate	VERB
fnp-3806	179	7	with	with	ADP
fnp-3806	179	8	variable	variable	ADJ
fnp-3806	179	9	alteration	alteration	NOUN
fnp-3806	179	10	of	of	ADP
fnp-3806	179	11	neuronal	neuronal	ADJ
fnp-3806	179	12	processes	process	NOUN
fnp-3806	179	13	,	,	PUNCT
fnp-3806	179	14	reactive	reactive	ADJ
fnp-3806	179	15	astrocytes	astrocyte	NOUN
fnp-3806	179	16	,	,	PUNCT
fnp-3806	179	17	and	and	CCONJ
fnp-3806	179	18	microglia	microglia	PROPN
fnp-3806	179	19	.	.	PUNCT
fnp-3806	180	1	altered	alter	VERB
fnp-3806	180	2	synaptic	synaptic	ADJ
fnp-3806	180	3	protein	protein	NOUN
fnp-3806	180	4	deposition	deposition	NOUN
fnp-3806	180	5	with	with	ADP
fnp-3806	180	6	a	a	DET
fnp-3806	180	7	granular	granular	ADJ
fnp-3806	180	8	pattern	pattern	NOUN
fnp-3806	180	9	is	be	AUX
fnp-3806	180	10	found	find	VERB
fnp-3806	180	11	in	in	ADP
fnp-3806	180	12	diffuse	diffuse	ADJ
fnp-3806	180	13	plaques	plaque	NOUN
fnp-3806	180	14	(	(	PUNCT
fnp-3806	180	15	129	129	NUM
fnp-3806	180	16	)	)	PUNCT
fnp-3806	180	17	.	.	PUNCT
fnp-3806	181	1	neurotransmitter	neurotransmitter	NOUN
fnp-3806	181	2	-	-	PUNCT
fnp-3806	181	3	containing	contain	VERB
fnp-3806	181	4	and	and	CCONJ
fnp-3806	181	5	peptidergic	peptidergic	ADJ
fnp-3806	181	6	dystrophic	dystrophic	ADJ
fnp-3806	181	7	neurites	neurite	NOUN
fnp-3806	181	8	precede	precede	VERB
fnp-3806	181	9	those	those	PRON
fnp-3806	181	10	containing	contain	VERB
fnp-3806	181	11	paired	pair	VERB
fnp-3806	181	12	helical	helical	ADJ
fnp-3806	181	13	filaments	filament	NOUN
fnp-3806	181	14	within	within	ADP
fnp-3806	181	15	sps	sps	NOUN
fnp-3806	181	16	(	(	PUNCT
fnp-3806	181	17	130	130	NUM
fnp-3806	181	18	-	-	NUM
fnp-3806	181	19	132	132	NUM
fnp-3806	181	20	)	)	PUNCT
fnp-3806	181	21	.	.	PUNCT
fnp-3806	182	1	altered	alter	VERB
fnp-3806	182	2	neuronal	neuronal	ADJ
fnp-3806	182	3	structure	structure	NOUN
fnp-3806	182	4	,	,	PUNCT
fnp-3806	182	5	accumulation	accumulation	NOUN
fnp-3806	182	6	of	of	ADP
fnp-3806	182	7	abnormal	abnormal	ADJ
fnp-3806	182	8	molecules	molecule	NOUN
fnp-3806	182	9	,	,	PUNCT
fnp-3806	182	10	and	and	CCONJ
fnp-3806	182	11	abnormal	abnormal	ADJ
fnp-3806	182	12	organelles	organelle	NOUN
fnp-3806	182	13	and	and	CCONJ
fnp-3806	182	14	debris	debris	NOUN
fnp-3806	182	15	are	be	AUX
fnp-3806	182	16	characteristic	characteristic	ADJ
fnp-3806	182	17	of	of	ADP
fnp-3806	182	18	dystrophic	dystrophic	ADJ
fnp-3806	182	19	neurites	neurite	NOUN
fnp-3806	182	20	of	of	ADP
fnp-3806	182	21	mature	mature	ADJ
fnp-3806	182	22	sps	sps	NOUN
fnp-3806	182	23	(	(	PUNCT
fnp-3806	182	24	133	133	NUM
fnp-3806	182	25	,	,	PUNCT
fnp-3806	182	26	135	135	NUM
fnp-3806	182	27	)	)	PUNCT
fnp-3806	182	28	.	.	PUNCT
fnp-3806	183	1	in	in	ADP
fnp-3806	183	2	addition	addition	NOUN
fnp-3806	183	3	to	to	ADP
fnp-3806	183	4	synaptic	synaptic	ADJ
fnp-3806	183	5	proteins	protein	NOUN
fnp-3806	183	6	,	,	PUNCT
fnp-3806	183	7	components	component	NOUN
fnp-3806	183	8	of	of	ADP
fnp-3806	183	9	dense	dense	ADJ
fnp-3806	183	10	-	-	PUNCT
fnp-3806	183	11	core	core	NOUN
fnp-3806	183	12	vesicles	vesicle	NOUN
fnp-3806	183	13	accumulate	accumulate	VERB
fnp-3806	183	14	in	in	ADP
fnp-3806	183	15	dystrophic	dystrophic	ADJ
fnp-3806	183	16	neurites	neurite	NOUN
fnp-3806	183	17	of	of	ADP
fnp-3806	183	18	sps	sps	PROPN
fnp-3806	183	19	(	(	PUNCT
fnp-3806	183	20	129	129	NUM
fnp-3806	183	21	,	,	PUNCT
fnp-3806	183	22	135	135	NUM
fnp-3806	183	23	-	-	NUM
fnp-3806	183	24	138	138	NUM
fnp-3806	183	25	)	)	PUNCT
fnp-3806	183	26	.	.	PUNCT
fnp-3806	184	1	immunohistochemical	immunohistochemical	ADJ
fnp-3806	184	2	studies	study	NOUN
fnp-3806	184	3	have	have	AUX
fnp-3806	184	4	shown	show	VERB
fnp-3806	184	5	that	that	PRON
fnp-3806	184	6	dystrophic	dystrophic	ADJ
fnp-3806	184	7	neurites	neurite	NOUN
fnp-3806	184	8	of	of	ADP
fnp-3806	184	9	sps	sps	PROPN
fnp-3806	184	10	contain	contain	VERB
fnp-3806	184	11	3rtau	3rtau	NUM
fnp-3806	184	12	and	and	CCONJ
fnp-3806	184	13	4rtau	4rtau	NUM
fnp-3806	184	14	;	;	PUNCT
fnp-3806	184	15	several	several	ADJ
fnp-3806	184	16	phospho	phospho	ADJ
fnp-3806	184	17	-	-	PUNCT
fnp-3806	184	18	tau	tau	NOUN
fnp-3806	184	19	species	specie	NOUN
fnp-3806	184	20	;	;	PUNCT
fnp-3806	184	21	map2	map2	NOUN
fnp-3806	184	22	-	-	PUNCT
fnp-3806	184	23	p	p	NOUN
fnp-3806	184	24	;	;	PUNCT
fnp-3806	184	25	phosphorylated	phosphorylate	VERB
fnp-3806	184	26	neurofilaments	neurofilament	NOUN
fnp-3806	184	27	light	light	ADJ
fnp-3806	184	28	;	;	PUNCT
fnp-3806	184	29	medium	medium	ADJ
fnp-3806	184	30	and	and	CCONJ
fnp-3806	184	31	heavy	heavy	ADJ
fnp-3806	184	32	chains	chain	NOUN
fnp-3806	184	33	;	;	PUNCT
fnp-3806	184	34	and	and	CCONJ
fnp-3806	184	35	active	active	ADJ
fnp-3806	184	36	kinases	kinase	NOUN
fnp-3806	184	37	p38	p38	PROPN
fnp-3806	184	38	,	,	PUNCT
fnp-3806	184	39	sapk	sapk	PROPN
fnp-3806	184	40	/	/	SYM
fnp-3806	184	41	jnk	jnk	PROPN
fnp-3806	184	42	,	,	PUNCT
fnp-3806	184	43	gsk3β	gsk3β	PROPN
fnp-3806	184	44	,	,	PUNCT
fnp-3806	184	45	and	and	CCONJ
fnp-3806	184	46	ck1	ck1	PROPN
fnp-3806	184	47	-	-	PUNCT
fnp-3806	184	48	δ	δ	PROPN
fnp-3806	184	49	,	,	PUNCT
fnp-3806	184	50	in	in	ADP
fnp-3806	184	51	addition	addition	NOUN
fnp-3806	184	52	to	to	ADP
fnp-3806	184	53	markers	marker	NOUN
fnp-3806	184	54	of	of	ADP
fnp-3806	184	55	the	the	DET
fnp-3806	184	56	ubiquitin	ubiquitin	ADJ
fnp-3806	184	57	-	-	PUNCT
fnp-3806	184	58	proteasome	proteasome	NOUN
fnp-3806	184	59	system	system	NOUN
fnp-3806	184	60	(	(	PUNCT
fnp-3806	184	61	ups	up	NOUN
fnp-3806	184	62	)	)	PUNCT
fnp-3806	184	63	and	and	CCONJ
fnp-3806	184	64	autophagy	autophagy	NOUN
fnp-3806	184	65	(	(	PUNCT
fnp-3806	184	66	139	139	NUM
fnp-3806	184	67	)	)	PUNCT
fnp-3806	184	68	.	.	PUNCT
fnp-3806	185	1	mitochondria	mitochondria	PROPN
fnp-3806	185	2	are	be	AUX
fnp-3806	185	3	altered	alter	VERB
fnp-3806	185	4	in	in	ADP
fnp-3806	185	5	dystrophic	dystrophic	ADJ
fnp-3806	185	6	neurites	neurite	NOUN
fnp-3806	185	7	of	of	ADP
fnp-3806	185	8	sps	sps	PROPN
fnp-3806	185	9	with	with	ADP
fnp-3806	185	10	variable	variable	ADJ
fnp-3806	185	11	vulnerability	vulnerability	NOUN
fnp-3806	185	12	of	of	ADP
fnp-3806	185	13	the	the	DET
fnp-3806	185	14	mitochondrial	mitochondrial	ADJ
fnp-3806	185	15	complexes	complex	NOUN
fnp-3806	185	16	of	of	ADP
fnp-3806	185	17	the	the	DET
fnp-3806	185	18	respiratory	respiratory	ADJ
fnp-3806	185	19	chain	chain	NOUN
fnp-3806	185	20	(	(	PUNCT
fnp-3806	185	21	140	140	NUM
fnp-3806	185	22	,	,	PUNCT
fnp-3806	185	23	141	141	NUM
fnp-3806	185	24	)	)	PUNCT
fnp-3806	185	25	.	.	PUNCT
fnp-3806	186	1	dystrophic	dystrophic	ADJ
fnp-3806	186	2	neurites	neurite	NOUN
fnp-3806	186	3	are	be	AUX
fnp-3806	186	4	likely	likely	ADV
fnp-3806	186	5	derived	derive	VERB
fnp-3806	186	6	from	from	ADP
fnp-3806	186	7	axons	axon	NOUN
fnp-3806	186	8	arising	arise	VERB
fnp-3806	186	9	from	from	ADP
fnp-3806	186	10	diverse	diverse	ADJ
fnp-3806	186	11	neuronal	neuronal	ADJ
fnp-3806	186	12	populations	population	NOUN
fnp-3806	186	13	,	,	PUNCT
fnp-3806	186	14	as	as	SCONJ
fnp-3806	186	15	revealed	reveal	VERB
fnp-3806	186	16	by	by	ADP
fnp-3806	186	17	specific	specific	ADJ
fnp-3806	186	18	neuronal	neuronal	ADJ
fnp-3806	186	19	markers	marker	NOUN
fnp-3806	186	20	(	(	PUNCT
fnp-3806	186	21	130	130	NUM
fnp-3806	186	22	-	-	SYM
fnp-3806	186	23	132	132	NUM
fnp-3806	186	24	,	,	PUNCT
fnp-3806	186	25	142	142	NUM
fnp-3806	186	26	-	-	SYM
fnp-3806	186	27	146	146	NUM
fnp-3806	186	28	)	)	PUNCT
fnp-3806	186	29	therefore	therefore	ADV
fnp-3806	186	30	indicating	indicate	VERB
fnp-3806	186	31	that	that	SCONJ
fnp-3806	186	32	neuronal	neuronal	ADJ
fnp-3806	186	33	vulnerability	vulnerability	NOUN
fnp-3806	186	34	is	be	AUX
fnp-3806	186	35	not	not	PART
fnp-3806	186	36	restricted	restrict	VERB
fnp-3806	186	37	to	to	ADP
fnp-3806	186	38	a	a	DET
fnp-3806	186	39	single	single	ADJ
fnp-3806	186	40	cellular	cellular	ADJ
fnp-3806	186	41	population	population	NOUN
fnp-3806	186	42	.	.	PUNCT
fnp-3806	187	1	pyramidal	pyramidal	ADJ
fnp-3806	187	2	cells	cell	NOUN
fnp-3806	187	3	in	in	ADP
fnp-3806	187	4	the	the	DET
fnp-3806	187	5	vicinity	vicinity	NOUN
fnp-3806	187	6	of	of	ADP
fnp-3806	187	7	sps	sps	PROPN
fnp-3806	187	8	show	show	NOUN
fnp-3806	187	9	distorted	distort	VERB
fnp-3806	187	10	dendrites	dendrite	NOUN
fnp-3806	187	11	and	and	CCONJ
fnp-3806	187	12	loss	loss	NOUN
fnp-3806	187	13	of	of	ADP
fnp-3806	187	14	dendritic	dendritic	ADJ
fnp-3806	187	15	spines	spine	NOUN
fnp-3806	187	16	(	(	PUNCT
fnp-3806	187	17	147	147	NUM
fnp-3806	187	18	-	-	SYM
fnp-3806	187	19	149	149	NUM
fnp-3806	187	20	)	)	PUNCT
fnp-3806	187	21	.	.	PUNCT
fnp-3806	188	1	2b	2b	NOUN
fnp-3806	188	2	.	.	PUNCT
fnp-3806	189	1	tau	tau	PROPN
fnp-3806	189	2	the	the	DET
fnp-3806	189	3	microtubule	microtubule	NOUN
fnp-3806	189	4	-	-	PUNCT
fnp-3806	189	5	associated	associate	VERB
fnp-3806	189	6	protein	protein	NOUN
fnp-3806	189	7	tau	tau	NOUN
fnp-3806	189	8	,	,	PUNCT
fnp-3806	189	9	encoded	encode	VERB
fnp-3806	189	10	by	by	ADP
fnp-3806	189	11	mapt	mapt	NOUN
fnp-3806	189	12	,	,	PUNCT
fnp-3806	189	13	participates	participate	VERB
fnp-3806	189	14	in	in	ADP
fnp-3806	189	15	microtubule	microtubule	NOUN
fnp-3806	189	16	stability	stability	NOUN
fnp-3806	189	17	,	,	PUNCT
fnp-3806	189	18	cellular	cellular	ADJ
fnp-3806	189	19	polarity	polarity	NOUN
fnp-3806	189	20	,	,	PUNCT
fnp-3806	189	21	and	and	CCONJ
fnp-3806	189	22	anterograde	anterograde	VERB
fnp-3806	189	23	and	and	CCONJ
fnp-3806	189	24	retrograde	retrograde	VERB
fnp-3806	189	25	axonal	axonal	ADJ
fnp-3806	189	26	transport	transport	NOUN
fnp-3806	189	27	of	of	ADP
fnp-3806	189	28	organelles	organelle	NOUN
fnp-3806	189	29	and	and	CCONJ
fnp-3806	189	30	vesicles	vesicle	NOUN
fnp-3806	189	31	.	.	PUNCT
fnp-3806	190	1	in	in	ADP
fnp-3806	190	2	addition	addition	NOUN
fnp-3806	190	3	to	to	ADP
fnp-3806	190	4	microtubules	microtubule	NOUN
fnp-3806	190	5	and	and	CCONJ
fnp-3806	190	6	actin	actin	NOUN
fnp-3806	190	7	,	,	PUNCT
fnp-3806	190	8	tau	tau	PROPN
fnp-3806	190	9	interacts	interact	VERB
fnp-3806	190	10	with	with	ADP
fnp-3806	190	11	a	a	DET
fnp-3806	190	12	large	large	ADJ
fnp-3806	190	13	number	number	NOUN
fnp-3806	190	14	of	of	ADP
fnp-3806	190	15	proteins	protein	NOUN
fnp-3806	190	16	and	and	CCONJ
fnp-3806	190	17	lipids	lipid	NOUN
fnp-3806	190	18	in	in	ADP
fnp-3806	190	19	the	the	DET
fnp-3806	190	20	cytoplasm	cytoplasm	NOUN
fnp-3806	190	21	,	,	PUNCT
fnp-3806	190	22	cell	cell	NOUN
fnp-3806	190	23	membranes	membrane	NOUN
fnp-3806	190	24	,	,	PUNCT
fnp-3806	190	25	and	and	CCONJ
fnp-3806	190	26	synapses	synapsis	NOUN
fnp-3806	190	27	,	,	PUNCT
fnp-3806	190	28	and	and	CCONJ
fnp-3806	190	29	with	with	ADP
fnp-3806	190	30	dna	dna	NOUN
fnp-3806	190	31	and	and	CCONJ
fnp-3806	190	32	proteins	protein	NOUN
fnp-3806	190	33	involved	involve	VERB
fnp-3806	190	34	in	in	ADP
fnp-3806	190	35	dna	dna	PROPN
fnp-3806	190	36	protection	protection	NOUN
fnp-3806	190	37	,	,	PUNCT
fnp-3806	190	38	among	among	ADP
fnp-3806	190	39	many	many	ADJ
fnp-3806	190	40	other	other	ADJ
fnp-3806	190	41	substrates	substrate	NOUN
fnp-3806	190	42	(	(	PUNCT
fnp-3806	190	43	150	150	NUM
fnp-3806	190	44	,	,	PUNCT
fnp-3806	190	45	151	151	NUM
fnp-3806	190	46	)	)	PUNCT
fnp-3806	190	47	.	.	PUNCT
fnp-3806	191	1	the	the	DET
fnp-3806	191	2	various	various	ADJ
fnp-3806	191	3	functions	function	NOUN
fnp-3806	191	4	of	of	ADP
fnp-3806	191	5	tau	tau	PROPN
fnp-3806	191	6	require	require	VERB
fnp-3806	191	7	interaction	interaction	NOUN
fnp-3806	191	8	with	with	ADP
fnp-3806	191	9	multiple	multiple	ADJ
fnp-3806	191	10	partners	partner	NOUN
fnp-3806	191	11	(	(	PUNCT
fnp-3806	191	12	151	151	NUM
fnp-3806	191	13	-	-	SYM
fnp-3806	191	14	157	157	NUM
fnp-3806	191	15	)	)	PUNCT
fnp-3806	191	16	.	.	PUNCT
fnp-3806	192	1	figure	figure	VERB
fnp-3806	192	2	5	5	NUM
fnp-3806	192	3	:	:	PUNCT
fnp-3806	192	4	neurofibrillary	neurofibrillary	ADJ
fnp-3806	192	5	tangles	tangle	NOUN
fnp-3806	192	6	in	in	ADP
fnp-3806	192	7	the	the	DET
fnp-3806	192	8	ca1	ca1	PROPN
fnp-3806	192	9	region	region	NOUN
fnp-3806	192	10	of	of	ADP
fnp-3806	192	11	the	the	DET
fnp-3806	192	12	hippocampus	hippocampus	NOUN
fnp-3806	192	13	.	.	PUNCT
fnp-3806	193	1	paraffin	paraffin	NOUN
fnp-3806	193	2	section	section	NOUN
fnp-3806	193	3	,	,	PUNCT
fnp-3806	193	4	at8	at8	PROPN
fnp-3806	193	5	immunohistochemistry	immunohistochemistry	NOUN
fnp-3806	193	6	,	,	PUNCT
fnp-3806	193	7	slight	slight	ADJ
fnp-3806	193	8	haematoxylin	haematoxylin	NOUN
fnp-3806	193	9	counterstaining	counterstaining	NOUN
fnp-3806	193	10	,	,	PUNCT
fnp-3806	193	11	bar	bar	NOUN
fnp-3806	193	12	=	=	SYM
fnp-3806	193	13	25μm	25μm	NOUN
fnp-3806	193	14	.	.	PUNCT
fnp-3806	194	1	the	the	DET
fnp-3806	194	2	main	main	ADJ
fnp-3806	194	3	constituent	constituent	NOUN
fnp-3806	194	4	of	of	ADP
fnp-3806	194	5	nfts	nft	NOUN
fnp-3806	194	6	dystrophic	dystrophic	ADJ
fnp-3806	194	7	neurites	neurite	NOUN
fnp-3806	194	8	of	of	ADP
fnp-3806	194	9	sps	sps	PROPN
fnp-3806	194	10	and	and	CCONJ
fnp-3806	194	11	neuropil	neuropil	PROPN
fnp-3806	194	12	threads	thread	NOUN
fnp-3806	194	13	is	be	AUX
fnp-3806	194	14	abnormal	abnormal	ADJ
fnp-3806	194	15	tau	tau	NOUN
fnp-3806	194	16	(	(	PUNCT
fnp-3806	194	17	158	158	NUM
fnp-3806	194	18	-	-	SYM
fnp-3806	194	19	173	173	NUM
fnp-3806	194	20	)	)	PUNCT
fnp-3806	194	21	(	(	PUNCT
fnp-3806	194	22	figures	figure	NOUN
fnp-3806	194	23	5	5	NUM
fnp-3806	194	24	,	,	PUNCT
fnp-3806	194	25	6	6	NUM
fnp-3806	194	26	,	,	PUNCT
fnp-3806	194	27	and	and	CCONJ
fnp-3806	194	28	7	7	NUM
fnp-3806	194	29	)	)	PUNCT
fnp-3806	194	30	.	.	PUNCT
fnp-3806	195	1	a	a	DET
fnp-3806	195	2	combination	combination	NOUN
fnp-3806	195	3	of	of	ADP
fnp-3806	195	4	all	all	DET
fnp-3806	195	5	six	six	NUM
fnp-3806	195	6	hyper	hyper	ADV
fnp-3806	195	7	-	-	ADJ
fnp-3806	195	8	phosphorylated	phosphorylate	VERB
fnp-3806	195	9	brain	brain	NOUN
fnp-3806	195	10	tau	tau	NOUN
fnp-3806	195	11	isoforms	isoform	VERB
fnp-3806	195	12	(	(	PUNCT
fnp-3806	195	13	3rtau	3rtau	NUM
fnp-3806	195	14	and	and	CCONJ
fnp-3806	195	15	4rtau	4rtau	NUM
fnp-3806	195	16	expressed	express	VERB
fnp-3806	195	17	in	in	ADP
fnp-3806	195	18	brain	brain	NOUN
fnp-3806	195	19	)	)	PUNCT
fnp-3806	195	20	,	,	PUNCT
fnp-3806	195	21	generated	generate	VERB
fnp-3806	195	22	from	from	ADP
fnp-3806	195	23	alternative	alternative	ADJ
fnp-3806	195	24	tau	tau	PROPN
fnp-3806	195	25	splicing	splicing	NOUN
fnp-3806	195	26	,	,	PUNCT
fnp-3806	195	27	is	be	AUX
fnp-3806	195	28	characteristic	characteristic	ADJ
fnp-3806	195	29	of	of	ADP
fnp-3806	195	30	ad	ad	NOUN
fnp-3806	195	31	tau	tau	PROPN
fnp-3806	195	32	(	(	PUNCT
fnp-3806	195	33	163	163	NUM
fnp-3806	195	34	,	,	PUNCT
fnp-3806	195	35	174	174	NUM
fnp-3806	195	36	,	,	PUNCT
fnp-3806	195	37	175	175	NUM
fnp-3806	195	38	)	)	PUNCT
fnp-3806	195	39	.	.	PUNCT
fnp-3806	196	1	the	the	DET
fnp-3806	196	2	amount	amount	NOUN
fnp-3806	196	3	of	of	ADP
fnp-3806	196	4	3rtau	3rtau	NUM
fnp-3806	196	5	is	be	AUX
fnp-3806	196	6	similar	similar	ADJ
fnp-3806	196	7	to	to	ADP
fnp-3806	196	8	4rtau	4rtau	NUM
fnp-3806	196	9	in	in	ADP
fnp-3806	196	10	the	the	DET
fnp-3806	196	11	human	human	ADJ
fnp-3806	196	12	adult	adult	NOUN
fnp-3806	196	13	brain	brain	NOUN
fnp-3806	196	14	and	and	CCONJ
fnp-3806	196	15	in	in	ADP
fnp-3806	196	16	ad	ad	NOUN
fnp-3806	196	17	.	.	PUNCT
fnp-3806	197	1	however	however	ADV
fnp-3806	197	2	,	,	PUNCT
fnp-3806	197	3	possible	possible	ADJ
fnp-3806	197	4	variations	variation	NOUN
fnp-3806	197	5	in	in	ADP
fnp-3806	197	6	the	the	DET
fnp-3806	197	7	ratio	ratio	NOUN
fnp-3806	197	8	of	of	ADP
fnp-3806	197	9	3rtau/4rtau	3rtau/4rtau	NUM
fnp-3806	197	10	among	among	ADP
fnp-3806	197	11	cell	cell	NOUN
fnp-3806	197	12	types	type	NOUN
fnp-3806	197	13	in	in	ADP
fnp-3806	197	14	the	the	DET
fnp-3806	197	15	human	human	ADJ
fnp-3806	197	16	brain	brain	NOUN
fnp-3806	197	17	have	have	AUX
fnp-3806	197	18	not	not	PART
fnp-3806	197	19	been	be	AUX
fnp-3806	197	20	adequately	adequately	ADV
fnp-3806	197	21	assessed	assess	VERB
fnp-3806	197	22	.	.	PUNCT
fnp-3806	198	1	abnormal	abnormal	ADJ
fnp-3806	198	2	tau	tau	PROPN
fnp-3806	198	3	in	in	ADP
fnp-3806	198	4	ad	ad	NOUN
fnp-3806	198	5	includes	include	VERB
fnp-3806	198	6	several	several	ADJ
fnp-3806	198	7	species	specie	NOUN
fnp-3806	198	8	resulting	result	VERB
fnp-3806	198	9	from	from	ADP
fnp-3806	198	10	hyper	hyper	NOUN
fnp-3806	198	11	-	-	NOUN
fnp-3806	198	12	phosphorylation	phosphorylation	NOUN
fnp-3806	198	13	at	at	ADP
fnp-3806	198	14	different	different	ADJ
fnp-3806	198	15	sites	site	NOUN
fnp-3806	198	16	,	,	PUNCT
fnp-3806	198	17	acetylation	acetylation	NOUN
fnp-3806	198	18	,	,	PUNCT
fnp-3806	198	19	glycosylation	glycosylation	NOUN
fnp-3806	198	20	,	,	PUNCT
fnp-3806	198	21	altered	alter	VERB
fnp-3806	198	22	confor	confor	PROPN
fnp-3806	198	23	mation	mation	PROPN
fnp-3806	198	24	,	,	PUNCT
fnp-3806	198	25	truncation	truncation	NOUN
fnp-3806	198	26	at	at	ADP
fnp-3806	198	27	glutamic	glutamic	ADJ
fnp-3806	198	28	acid	acid	NOUN
fnp-3806	198	29	391	391	NUM
fnp-3806	198	30	and	and	CCONJ
fnp-3806	198	31	at	at	ADP
fnp-3806	198	32	aspartic	aspartic	ADJ
fnp-3806	198	33	acid	acid	NOUN
fnp-3806	198	34	421	421	NUM
fnp-3806	198	35	(	(	PUNCT
fnp-3806	198	36	mediated	mediate	VERB
fnp-3806	198	37	by	by	ADP
fnp-3806	198	38	caspase	caspase	PROPN
fnp-3806	198	39	3	3	NUM
fnp-3806	198	40	)	)	PUNCT
fnp-3806	198	41	,	,	PUNCT
fnp-3806	198	42	oligomerization	oligomerization	NOUN
fnp-3806	198	43	,	,	PUNCT
fnp-3806	198	44	and	and	CCONJ
fnp-3806	198	45	β	β	X
fnp-3806	198	46	-	-	ADJ
fnp-3806	198	47	sheet	sheet	NOUN
fnp-3806	198	48	-	-	PUNCT
fnp-3806	198	49	rich	rich	ADJ
fnp-3806	198	50	fibril	fibril	ADJ
fnp-3806	198	51	aggregation	aggregation	NOUN
fnp-3806	198	52	,	,	PUNCT
fnp-3806	198	53	among	among	ADP
fnp-3806	198	54	others	other	NOUN
fnp-3806	198	55	(	(	PUNCT
fnp-3806	198	56	171	171	NUM
fnp-3806	198	57	-	-	SYM
fnp-3806	198	58	173	173	NUM
fnp-3806	198	59	,	,	PUNCT
fnp-3806	198	60	176	176	NUM
fnp-3806	198	61	-	-	SYM
fnp-3806	198	62	196	196	NUM
fnp-3806	198	63	)	)	PUNCT
fnp-3806	198	64	.	.	PUNCT
fnp-3806	199	1	the	the	DET
fnp-3806	199	2	site	site	NOUN
fnp-3806	199	3	of	of	ADP
fnp-3806	199	4	tau	tau	PROPN
fnp-3806	199	5	phosphorylation	phosphorylation	NOUN
fnp-3806	199	6	and	and	CCONJ
fnp-3806	199	7	other	other	ADJ
fnp-3806	199	8	post	post	ADJ
fnp-3806	199	9	-	-	ADJ
fnp-3806	199	10	translational	translational	ADJ
fnp-3806	199	11	modifications	modification	NOUN
fnp-3806	199	12	in	in	ADP
fnp-3806	199	13	tau	tau	PROPN
fnp-3806	199	14	have	have	VERB
fnp-3806	199	15	commonalities	commonality	NOUN
fnp-3806	199	16	and	and	CCONJ
fnp-3806	199	17	differences	difference	NOUN
fnp-3806	199	18	among	among	ADP
fnp-3806	199	19	tauopathies	tauopathie	NOUN
fnp-3806	199	20	(	(	PUNCT
fnp-3806	199	21	197	197	NUM
fnp-3806	199	22	,	,	PUNCT
fnp-3806	199	23	198	198	NUM
fnp-3806	199	24	)	)	PUNCT
fnp-3806	199	25	.	.	PUNCT
fnp-3806	200	1	tau	tau	PROPN
fnp-3806	200	2	inclusions	inclusion	NOUN
fnp-3806	200	3	in	in	ADP
fnp-3806	200	4	glial	glial	ADJ
fnp-3806	200	5	cells	cell	NOUN
fnp-3806	200	6	are	be	AUX
fnp-3806	200	7	not	not	PART
fnp-3806	200	8	found	find	VERB
fnp-3806	200	9	in	in	ADP
fnp-3806	200	10	ad	ad	NOUN
fnp-3806	200	11	,	,	PUNCT
fnp-3806	200	12	unless	unless	SCONJ
fnp-3806	200	13	accompanied	accompany	VERB
fnp-3806	200	14	by	by	ADP
fnp-3806	200	15	other	other	ADJ
fnp-3806	200	16	tau	tau	PROPN
fnp-3806	200	17	co	co	NOUN
fnp-3806	200	18	-	-	NOUN
fnp-3806	200	19	morbidities	morbidity	NOUN
fnp-3806	200	20	including	include	VERB
fnp-3806	200	21	aging	age	VERB
fnp-3806	200	22	-	-	PUNCT
fnp-3806	200	23	related	relate	VERB
fnp-3806	200	24	tau	tau	PROPN
fnp-3806	200	25	astrogliopathy	astrogliopathy	ADJ
fnp-3806	200	26	(	(	PUNCT
fnp-3806	200	27	artag	artag	ADJ
fnp-3806	200	28	)	)	PUNCT
fnp-3806	200	29	and	and	CCONJ
fnp-3806	200	30	argyrophilic	argyrophilic	ADJ
fnp-3806	200	31	grain	grain	NOUN
fnp-3806	200	32	disease	disease	NOUN
fnp-3806	200	33	(	(	PUNCT
fnp-3806	200	34	agd	agd	PROPN
fnp-3806	200	35	)	)	PUNCT
fnp-3806	200	36	which	which	PRON
fnp-3806	200	37	are	be	AUX
fnp-3806	200	38	4rtau	4rtau	ADV
fnp-3806	200	39	-	-	PUNCT
fnp-3806	200	40	only	only	ADV
fnp-3806	200	41	tauopathies	tauopathie	NOUN
fnp-3806	200	42	.	.	PUNCT
fnp-3806	201	1	figure	figure	VERB
fnp-3806	201	2	6	6	NUM
fnp-3806	201	3	:	:	PUNCT
fnp-3806	201	4	dystrophic	dystrophic	ADJ
fnp-3806	201	5	neurites	neurite	NOUN
fnp-3806	201	6	of	of	ADP
fnp-3806	201	7	sps	sps	PROPN
fnp-3806	201	8	in	in	ADP
fnp-3806	201	9	the	the	DET
fnp-3806	201	10	entorhinal	entorhinal	ADJ
fnp-3806	201	11	cortex	cortex	NOUN
fnp-3806	201	12	containing	contain	VERB
fnp-3806	201	13	hyper	hyper	ADV
fnp-3806	201	14	-	-	ADJ
fnp-3806	201	15	phosphorylated	phosphorylate	VERB
fnp-3806	201	16	tau	tau	NOUN
fnp-3806	201	17	.	.	PUNCT
fnp-3806	202	1	paraffin	paraffin	NOUN
fnp-3806	202	2	section	section	NOUN
fnp-3806	202	3	,	,	PUNCT
fnp-3806	202	4	at8	at8	PROPN
fnp-3806	202	5	immunohistochemistry	immunohistochemistry	NOUN
fnp-3806	202	6	,	,	PUNCT
fnp-3806	202	7	slight	slight	ADJ
fnp-3806	202	8	haematoxylin	haematoxylin	NOUN
fnp-3806	202	9	counterstaing	counterstaing	NOUN
fnp-3806	202	10	,	,	PUNCT
fnp-3806	202	11	bar	bar	NOUN
fnp-3806	202	12	=	=	SYM
fnp-3806	202	13	25μm	25μm	NUM
fnp-3806	202	14	figure	figure	NOUN
fnp-3806	202	15	7	7	NUM
fnp-3806	202	16	:	:	PUNCT
fnp-3806	202	17	immunoelectron	immunoelectron	ADJ
fnp-3806	202	18	microscopy	microscopy	NOUN
fnp-3806	202	19	showing	show	VERB
fnp-3806	202	20	phospho	phospho	ADJ
fnp-3806	202	21	-	-	PUNCT
fnp-3806	202	22	tau	tau	NOUN
fnp-3806	202	23	deposits	deposit	NOUN
fnp-3806	202	24	(	(	PUNCT
fnp-3806	202	25	black	black	ADJ
fnp-3806	202	26	dots	dot	NOUN
fnp-3806	202	27	)	)	PUNCT
fnp-3806	202	28	in	in	ADP
fnp-3806	202	29	paired	pair	VERB
fnp-3806	202	30	helical	helical	ADJ
fnp-3806	202	31	filaments	filament	NOUN
fnp-3806	202	32	.	.	PUNCT
fnp-3806	203	1	at8	at8	NOUN
fnp-3806	203	2	antibody	antibody	NOUN
fnp-3806	203	3	,	,	PUNCT
fnp-3806	203	4	bar	bar	NOUN
fnp-3806	203	5	=	=	SYM
fnp-3806	203	6	0.2μm	0.2μm	PROPN
fnp-3806	203	7	.	.	PUNCT
fnp-3806	204	1	tau	tau	PROPN
fnp-3806	204	2	hyper	hyper	NOUN
fnp-3806	204	3	-	-	NOUN
fnp-3806	204	4	phosphorylation	phosphorylation	NOUN
fnp-3806	204	5	,	,	PUNCT
fnp-3806	204	6	the	the	DET
fnp-3806	204	7	first	first	ADJ
fnp-3806	204	8	step	step	NOUN
fnp-3806	204	9	in	in	ADP
fnp-3806	204	10	nft	nft	PROPN
fnp-3806	204	11	formation	formation	NOUN
fnp-3806	204	12	,	,	PUNCT
fnp-3806	204	13	is	be	AUX
fnp-3806	204	14	geared	gear	VERB
fnp-3806	204	15	by	by	ADP
fnp-3806	204	16	the	the	DET
fnp-3806	204	17	activation	activation	NOUN
fnp-3806	204	18	of	of	ADP
fnp-3806	204	19	specific	specific	ADJ
fnp-3806	204	20	kinases	kinase	NOUN
fnp-3806	204	21	,	,	PUNCT
fnp-3806	204	22	and	and	CCONJ
fnp-3806	204	23	probably	probably	ADV
fnp-3806	204	24	also	also	ADV
fnp-3806	204	25	by	by	ADP
fnp-3806	204	26	accompanying	accompany	VERB
fnp-3806	204	27	inhibition	inhibition	NOUN
fnp-3806	204	28	of	of	ADP
fnp-3806	204	29	phosphatases	phosphatase	NOUN
fnp-3806	204	30	(	(	PUNCT
fnp-3806	204	31	171	171	NUM
fnp-3806	204	32	,	,	PUNCT
fnp-3806	204	33	199	199	NUM
fnp-3806	204	34	)	)	PUNCT
fnp-3806	204	35	.	.	PUNCT
fnp-3806	205	1	several	several	ADJ
fnp-3806	205	2	kinases	kinase	NOUN
fnp-3806	205	3	are	be	AUX
fnp-3806	205	4	implicated	implicate	VERB
fnp-3806	205	5	in	in	ADP
fnp-3806	205	6	both	both	CCONJ
fnp-3806	205	7	the	the	DET
fnp-3806	205	8	physiological	physiological	NOUN
fnp-3806	205	9	and	and	CCONJ
fnp-3806	205	10	the	the	DET
fnp-3806	205	11	pathological	pathological	ADJ
fnp-3806	205	12	phosphorylation	phosphorylation	NOUN
fnp-3806	205	13	of	of	ADP
fnp-3806	205	14	tau	tau	PROPN
fnp-3806	205	15	,	,	PUNCT
fnp-3806	205	16	including	include	VERB
fnp-3806	205	17	glycogen	glycogen	NOUN
fnp-3806	205	18	synthase	synthase	NOUN
fnp-3806	205	19	kinase	kinase	PROPN
fnp-3806	205	20	3β	3β	NUM
fnp-3806	205	21	(	(	PUNCT
fnp-3806	205	22	gsk3β	gsk3β	PROPN
fnp-3806	205	23	)	)	PUNCT
fnp-3806	205	24	;	;	PUNCT
fnp-3806	205	25	cyclin	cyclin	NOUN
fnp-3806	205	26	-	-	PUNCT
fnp-3806	205	27	dependent	dependent	ADJ
fnp-3806	205	28	kinase	kinase	NOUN
fnp-3806	205	29	5	5	NUM
fnp-3806	205	30	(	(	PUNCT
fnp-3806	205	31	cdk5	cdk5	PROPN
fnp-3806	205	32	)	)	PUNCT
fnp-3806	205	33	;	;	PUNCT
fnp-3806	205	34	protein	protein	NOUN
fnp-3806	205	35	kinase	kinase	NOUN
fnp-3806	205	36	a	a	DET
fnp-3806	205	37	(	(	PUNCT
fnp-3806	205	38	pka	pka	PROPN
fnp-3806	205	39	)	)	PUNCT
fnp-3806	205	40	;	;	PUNCT
fnp-3806	205	41	jun	jun	PROPN
fnp-3806	205	42	n	n	CCONJ
fnp-3806	205	43	-	-	PUNCT
fnp-3806	205	44	terminal	terminal	ADJ
fnp-3806	205	45	kinase	kinase	NOUN
fnp-3806	205	46	(	(	PUNCT
fnp-3806	205	47	jnk	jnk	PROPN
fnp-3806	205	48	)	)	PUNCT
fnp-3806	205	49	;	;	PUNCT
fnp-3806	205	50	p38	p38	NOUN
fnp-3806	205	51	;	;	PUNCT
fnp-3806	205	52	and	and	CCONJ
fnp-3806	205	53	others	other	NOUN
fnp-3806	205	54	(	(	PUNCT
fnp-3806	205	55	200	200	NUM
fnp-3806	205	56	)	)	PUNCT
fnp-3806	205	57	.	.	PUNCT
fnp-3806	206	1	co	co	NOUN
fnp-3806	206	2	-	-	NOUN
fnp-3806	206	3	localization	localization	NOUN
fnp-3806	206	4	of	of	ADP
fnp-3806	206	5	selected	select	VERB
fnp-3806	206	6	active	active	ADJ
fnp-3806	206	7	kinases	kinase	NOUN
fnp-3806	206	8	and	and	CCONJ
fnp-3806	206	9	tau	tau	PROPN
fnp-3806	206	10	deposits	deposit	NOUN
fnp-3806	206	11	can	can	AUX
fnp-3806	206	12	be	be	AUX
fnp-3806	206	13	visualized	visualize	VERB
fnp-3806	206	14	in	in	ADP
fnp-3806	206	15	brain	brain	NOUN
fnp-3806	206	16	tissue	tissue	NOUN
fnp-3806	206	17	(	(	PUNCT
fnp-3806	206	18	201	201	NUM
fnp-3806	206	19	-	-	SYM
fnp-3806	206	20	203	203	NUM
fnp-3806	206	21	)	)	PUNCT
fnp-3806	206	22	.	.	PUNCT
fnp-3806	207	1	g	g	NOUN
fnp-3806	207	2	-	-	PUNCT
fnp-3806	207	3	protein	protein	NOUN
fnp-3806	207	4	-	-	PUNCT
fnp-3806	207	5	coupled	couple	VERB
fnp-3806	207	6	receptor	receptor	NOUN
fnp-3806	207	7	(	(	PUNCT
fnp-3806	207	8	gpcr	gpcr	ADJ
fnp-3806	207	9	)	)	PUNCT
fnp-3806	207	10	kinases	kinase	NOUN
fnp-3806	207	11	are	be	AUX
fnp-3806	207	12	also	also	ADV
fnp-3806	207	13	associated	associate	VERB
fnp-3806	207	14	with	with	ADP
fnp-3806	207	15	nfts	nft	NOUN
fnp-3806	207	16	and	and	CCONJ
fnp-3806	207	17	β	β	NOUN
fnp-3806	207	18	-	-	ADJ
fnp-3806	207	19	amyloid	amyloid	ADJ
fnp-3806	207	20	plaques	plaque	NOUN
fnp-3806	207	21	in	in	ADP
fnp-3806	207	22	ad	ad	NOUN
fnp-3806	207	23	(	(	PUNCT
fnp-3806	207	24	204	204	NUM
fnp-3806	207	25	)	)	PUNCT
fnp-3806	207	26	.	.	PUNCT
fnp-3806	208	1	these	these	DET
fnp-3806	208	2	alterations	alteration	NOUN
fnp-3806	208	3	are	be	AUX
fnp-3806	208	4	cumulative	cumulative	ADJ
fnp-3806	208	5	but	but	CCONJ
fnp-3806	208	6	not	not	PART
fnp-3806	208	7	homogeneous	homogeneous	ADJ
fnp-3806	208	8	.	.	PUNCT
fnp-3806	209	1	more	more	ADJ
fnp-3806	209	2	than	than	ADP
fnp-3806	209	3	one	one	NUM
fnp-3806	209	4	tau	tau	PROPN
fnp-3806	209	5	species	specie	NOUN
fnp-3806	209	6	may	may	AUX
fnp-3806	209	7	be	be	AUX
fnp-3806	209	8	present	present	ADJ
fnp-3806	209	9	in	in	ADP
fnp-3806	209	10	a	a	DET
fnp-3806	209	11	particular	particular	ADJ
fnp-3806	209	12	neuron	neuron	NOUN
fnp-3806	209	13	.	.	PUNCT
fnp-3806	210	1	furthermore	furthermore	ADV
fnp-3806	210	2	,	,	PUNCT
fnp-3806	210	3	distinct	distinct	ADJ
fnp-3806	210	4	defects	defect	NOUN
fnp-3806	210	5	may	may	AUX
fnp-3806	210	6	result	result	VERB
fnp-3806	210	7	depending	depend	VERB
fnp-3806	210	8	on	on	ADP
fnp-3806	210	9	the	the	DET
fnp-3806	210	10	type	type	NOUN
fnp-3806	210	11	of	of	ADP
fnp-3806	210	12	accumulated	accumulate	VERB
fnp-3806	210	13	tau	tau	PROPN
fnp-3806	210	14	,	,	PUNCT
fnp-3806	210	15	ranging	range	VERB
fnp-3806	210	16	from	from	ADP
fnp-3806	210	17	reversible	reversible	ADJ
fnp-3806	210	18	dysfunction	dysfunction	NOUN
fnp-3806	210	19	to	to	ADP
fnp-3806	210	20	irreversible	irreversible	ADJ
fnp-3806	210	21	disruption	disruption	NOUN
fnp-3806	210	22	of	of	ADP
fnp-3806	210	23	the	the	DET
fnp-3806	210	24	cytoskeleton	cytoskeleton	NOUN
fnp-3806	210	25	,	,	PUNCT
fnp-3806	210	26	altered	alter	VERB
fnp-3806	210	27	axonal	axonal	ADJ
fnp-3806	210	28	transport	transport	NOUN
fnp-3806	210	29	,	,	PUNCT
fnp-3806	210	30	undermined	undermined	ADJ
fnp-3806	210	31	cell	cell	NOUN
fnp-3806	210	32	signaling	signal	VERB
fnp-3806	210	33	,	,	PUNCT
fnp-3806	210	34	synaptic	synaptic	ADJ
fnp-3806	210	35	dysfunction	dysfunction	NOUN
fnp-3806	210	36	,	,	PUNCT
fnp-3806	210	37	and	and	CCONJ
fnp-3806	210	38	cell	cell	NOUN
fnp-3806	210	39	death	death	NOUN
fnp-3806	210	40	.	.	PUNCT
fnp-3806	211	1	tau	tau	NOUN
fnp-3806	211	2	-	-	PUNCT
fnp-3806	211	3	linked	link	VERB
fnp-3806	211	4	alterations	alteration	NOUN
fnp-3806	211	5	can	can	AUX
fnp-3806	211	6	be	be	AUX
fnp-3806	211	7	the	the	DET
fnp-3806	211	8	direct	direct	ADJ
fnp-3806	211	9	result	result	NOUN
fnp-3806	211	10	of	of	ADP
fnp-3806	211	11	toxic	toxic	ADJ
fnp-3806	211	12	species	specie	NOUN
fnp-3806	211	13	or	or	CCONJ
fnp-3806	211	14	the	the	DET
fnp-3806	211	15	interactions	interaction	NOUN
fnp-3806	211	16	of	of	ADP
fnp-3806	211	17	multiple	multiple	ADJ
fnp-3806	211	18	partners	partner	NOUN
fnp-3806	211	19	(	(	PUNCT
fnp-3806	211	20	156	156	NUM
fnp-3806	211	21	)	)	PUNCT
fnp-3806	211	22	.	.	PUNCT
fnp-3806	212	1	soluble	soluble	ADJ
fnp-3806	212	2	and	and	CCONJ
fnp-3806	212	3	insoluble	insoluble	ADJ
fnp-3806	212	4	tau	tau	PROPN
fnp-3806	212	5	oligomers	oligomer	NOUN
fnp-3806	212	6	,	,	PUNCT
fnp-3806	212	7	both	both	CCONJ
fnp-3806	212	8	phosphorylated	phosphorylate	VERB
fnp-3806	212	9	and	and	CCONJ
fnp-3806	212	10	non	non	ADJ
fnp-3806	212	11	-	-	ADJ
fnp-3806	212	12	phosphorylated	phosphorylated	ADJ
fnp-3806	212	13	,	,	PUNCT
fnp-3806	212	14	may	may	AUX
fnp-3806	212	15	be	be	AUX
fnp-3806	212	16	involved	involve	VERB
fnp-3806	212	17	in	in	ADP
fnp-3806	212	18	neurodegeneration	neurodegeneration	NOUN
fnp-3806	212	19	(	(	PUNCT
fnp-3806	212	20	191	191	NUM
fnp-3806	212	21	,	,	PUNCT
fnp-3806	212	22	205	205	NUM
fnp-3806	212	23	)	)	PUNCT
fnp-3806	212	24	.	.	PUNCT
fnp-3806	213	1	the	the	DET
fnp-3806	213	2	association	association	NOUN
fnp-3806	213	3	of	of	ADP
fnp-3806	213	4	tau	tau	PROPN
fnp-3806	213	5	with	with	ADP
fnp-3806	213	6	the	the	DET
fnp-3806	213	7	plasma	plasma	NOUN
fnp-3806	213	8	membrane	membrane	NOUN
fnp-3806	213	9	is	be	AUX
fnp-3806	213	10	determined	determine	VERB
fnp-3806	213	11	by	by	ADP
fnp-3806	213	12	its	its	PRON
fnp-3806	213	13	phosphorylation	phosphorylation	NOUN
fnp-3806	213	14	pattern	pattern	NOUN
fnp-3806	213	15	.	.	PUNCT
fnp-3806	214	1	tau	tau	PROPN
fnp-3806	214	2	associated	associate	VERB
fnp-3806	214	3	with	with	ADP
fnp-3806	214	4	the	the	DET
fnp-3806	214	5	plasma	plasma	NOUN
fnp-3806	214	6	membrane	membrane	NOUN
fnp-3806	214	7	can	can	AUX
fnp-3806	214	8	move	move	VERB
fnp-3806	214	9	to	to	ADP
fnp-3806	214	10	the	the	DET
fnp-3806	214	11	cytosol	cytosol	NOUN
fnp-3806	214	12	upon	upon	SCONJ
fnp-3806	214	13	tau	tau	PROPN
fnp-3806	214	14	hyper	hyper	NOUN
fnp-3806	214	15	-	-	NOUN
fnp-3806	214	16	phosphorlation	phosphorlation	NOUN
fnp-3806	214	17	(	(	PUNCT
fnp-3806	214	18	206	206	NUM
fnp-3806	214	19	,	,	PUNCT
fnp-3806	214	20	207	207	NUM
fnp-3806	214	21	)	)	PUNCT
fnp-3806	214	22	.	.	PUNCT
fnp-3806	215	1	the	the	DET
fnp-3806	215	2	phosphorylation	phosphorylation	NOUN
fnp-3806	215	3	of	of	ADP
fnp-3806	215	4	tau	tau	PROPN
fnp-3806	215	5	also	also	ADV
fnp-3806	215	6	depends	depend	VERB
fnp-3806	215	7	on	on	ADP
fnp-3806	215	8	phosphatidyl	phosphatidyl	ADJ
fnp-3806	215	9	choline	choline	NOUN
fnp-3806	215	10	and	and	CCONJ
fnp-3806	215	11	phosphatidyl	phosphatidyl	NOUN
fnp-3806	215	12	serine	serine	NOUN
fnp-3806	215	13	(	(	PUNCT
fnp-3806	215	14	208	208	NUM
fnp-3806	215	15	)	)	PUNCT
fnp-3806	215	16	.	.	PUNCT
fnp-3806	216	1	therefore	therefore	ADV
fnp-3806	216	2	,	,	PUNCT
fnp-3806	216	3	the	the	DET
fnp-3806	216	4	composition	composition	NOUN
fnp-3806	216	5	of	of	ADP
fnp-3806	216	6	lipids	lipid	NOUN
fnp-3806	216	7	at	at	ADP
fnp-3806	216	8	the	the	DET
fnp-3806	216	9	membrane	membrane	NOUN
fnp-3806	216	10	may	may	AUX
fnp-3806	216	11	modify	modify	VERB
fnp-3806	216	12	the	the	DET
fnp-3806	216	13	phosphorylation	phosphorylation	NOUN
fnp-3806	216	14	of	of	ADP
fnp-3806	216	15	tau	tau	PROPN
fnp-3806	216	16	and	and	CCONJ
fnp-3806	216	17	its	its	PRON
fnp-3806	216	18	capacity	capacity	NOUN
fnp-3806	216	19	to	to	PART
fnp-3806	216	20	shift	shift	VERB
fnp-3806	216	21	its	its	PRON
fnp-3806	216	22	binding	binding	NOUN
fnp-3806	216	23	with	with	ADP
fnp-3806	216	24	actin	actin	NOUN
fnp-3806	216	25	and	and	CCONJ
fnp-3806	216	26	cytosolic	cytosolic	ADJ
fnp-3806	216	27	proteins	protein	NOUN
fnp-3806	216	28	(	(	PUNCT
fnp-3806	216	29	209	209	NUM
fnp-3806	216	30	-	-	SYM
fnp-3806	216	31	211	211	NUM
fnp-3806	216	32	)	)	PUNCT
fnp-3806	216	33	.	.	PUNCT
fnp-3806	217	1	tau	tau	PROPN
fnp-3806	217	2	interactions	interaction	NOUN
fnp-3806	217	3	with	with	ADP
fnp-3806	217	4	the	the	DET
fnp-3806	217	5	membrane	membrane	NOUN
fnp-3806	217	6	have	have	VERB
fnp-3806	217	7	several	several	ADJ
fnp-3806	217	8	implications	implication	NOUN
fnp-3806	217	9	(	(	PUNCT
fnp-3806	217	10	155	155	NUM
fnp-3806	217	11	,	,	PUNCT
fnp-3806	217	12	212	212	NUM
fnp-3806	217	13	)	)	PUNCT
fnp-3806	217	14	.	.	PUNCT
fnp-3806	218	1	in	in	ADP
fnp-3806	218	2	addition	addition	NOUN
fnp-3806	218	3	to	to	ADP
fnp-3806	218	4	stabilizing	stabilize	VERB
fnp-3806	218	5	membrane	membrane	NOUN
fnp-3806	218	6	-	-	PUNCT
fnp-3806	218	7	cytosol	cytosol	NOUN
fnp-3806	218	8	interactions	interaction	NOUN
fnp-3806	218	9	,	,	PUNCT
fnp-3806	218	10	tau	tau	PROPN
fnp-3806	218	11	is	be	AUX
fnp-3806	218	12	secreted	secrete	VERB
fnp-3806	218	13	associated	associate	VERB
fnp-3806	218	14	to	to	ADP
fnp-3806	218	15	vesicles	vesicle	NOUN
fnp-3806	218	16	,	,	PUNCT
fnp-3806	218	17	or	or	CCONJ
fnp-3806	218	18	vesicle	vesicle	NOUN
fnp-3806	218	19	-	-	PUNCT
fnp-3806	218	20	free	free	ADJ
fnp-3806	218	21	,	,	PUNCT
fnp-3806	218	22	key	key	ADJ
fnp-3806	218	23	features	feature	NOUN
fnp-3806	218	24	in	in	ADP
fnp-3806	218	25	tau	tau	PROPN
fnp-3806	218	26	transmission	transmission	NOUN
fnp-3806	218	27	(	(	PUNCT
fnp-3806	218	28	213	213	NUM
fnp-3806	218	29	-	-	SYM
fnp-3806	218	30	215	215	NUM
fnp-3806	218	31	)	)	PUNCT
fnp-3806	218	32	.	.	PUNCT
fnp-3806	219	1	morphologically	morphologically	ADV
fnp-3806	219	2	,	,	PUNCT
fnp-3806	219	3	abnormal	abnormal	ADJ
fnp-3806	219	4	neuronal	neuronal	ADJ
fnp-3806	219	5	tau	tau	NOUN
fnp-3806	219	6	deposits	deposit	NOUN
fnp-3806	219	7	in	in	ADP
fnp-3806	219	8	ad	ad	NOUN
fnp-3806	219	9	are	be	AUX
fnp-3806	219	10	manifested	manifest	VERB
fnp-3806	219	11	as	as	ADP
fnp-3806	219	12	perinuclear	perinuclear	ADJ
fnp-3806	219	13	tau	tau	PROPN
fnp-3806	219	14	deposits	deposit	NOUN
fnp-3806	219	15	,	,	PUNCT
fnp-3806	219	16	granular	granular	ADJ
fnp-3806	219	17	cytoplasmic	cytoplasmic	ADJ
fnp-3806	219	18	deposits	deposit	NOUN
fnp-3806	219	19	,	,	PUNCT
fnp-3806	219	20	diffuse	diffuse	VERB
fnp-3806	219	21	cytoplasmic	cytoplasmic	ADJ
fnp-3806	219	22	deposits	deposit	NOUN
fnp-3806	219	23	(	(	PUNCT
fnp-3806	219	24	all	all	PRON
fnp-3806	219	25	considered	consider	VERB
fnp-3806	219	26	pre	pre	ADJ
fnp-3806	219	27	-	-	ADJ
fnp-3806	219	28	tangle	tangle	ADJ
fnp-3806	219	29	stages	stage	NOUN
fnp-3806	219	30	)	)	PUNCT
fnp-3806	219	31	,	,	PUNCT
fnp-3806	219	32	neurofibrillary	neurofibrillary	ADJ
fnp-3806	219	33	tangles	tangle	NOUN
fnp-3806	219	34	(	(	PUNCT
fnp-3806	219	35	classical	classical	ADJ
fnp-3806	219	36	nfts	nft	NOUN
fnp-3806	219	37	)	)	PUNCT
fnp-3806	219	38	,	,	PUNCT
fnp-3806	219	39	ghost	ghost	NOUN
fnp-3806	219	40	tangles	tangle	NOUN
fnp-3806	219	41	(	(	PUNCT
fnp-3806	219	42	remains	remain	VERB
fnp-3806	219	43	of	of	ADP
fnp-3806	219	44	nfts	nft	NOUN
fnp-3806	219	45	in	in	ADP
fnp-3806	219	46	the	the	DET
fnp-3806	219	47	neuropil	neuropil	NOUN
fnp-3806	219	48	)	)	PUNCT
fnp-3806	219	49	,	,	PUNCT
fnp-3806	219	50	dystrophic	dystrophic	ADJ
fnp-3806	219	51	neurites	neurite	NOUN
fnp-3806	219	52	of	of	ADP
fnp-3806	219	53	sps	sps	PROPN
fnp-3806	219	54	,	,	PUNCT
fnp-3806	219	55	and	and	CCONJ
fnp-3806	219	56	neuropil	neuropil	NOUN
fnp-3806	219	57	threads	thread	NOUN
fnp-3806	219	58	.	.	PUNCT
fnp-3806	220	1	the	the	DET
fnp-3806	220	2	redistribution	redistribution	NOUN
fnp-3806	220	3	of	of	ADP
fnp-3806	220	4	abnormal	abnormal	ADJ
fnp-3806	220	5	tau	tau	PROPN
fnp-3806	220	6	from	from	ADP
fnp-3806	220	7	axons	axon	NOUN
fnp-3806	220	8	to	to	ADP
fnp-3806	220	9	the	the	DET
fnp-3806	220	10	somatodendritic	somatodendritic	ADJ
fnp-3806	220	11	compartment	compartment	NOUN
fnp-3806	220	12	of	of	ADP
fnp-3806	220	13	neurons	neuron	NOUN
fnp-3806	220	14	and	and	CCONJ
fnp-3806	220	15	dendritic	dendritic	ADJ
fnp-3806	220	16	spines	spine	NOUN
fnp-3806	220	17	is	be	AUX
fnp-3806	220	18	a	a	DET
fnp-3806	220	19	characteristic	characteristic	ADJ
fnp-3806	220	20	consequence	consequence	NOUN
fnp-3806	220	21	of	of	ADP
fnp-3806	220	22	tau	tau	PROPN
fnp-3806	220	23	pathology	pathology	NOUN
fnp-3806	220	24	in	in	ADP
fnp-3806	220	25	ad	ad	NOUN
fnp-3806	220	26	and	and	CCONJ
fnp-3806	220	27	other	other	ADJ
fnp-3806	220	28	tauopathies	tauopathie	NOUN
fnp-3806	220	29	.	.	PUNCT
fnp-3806	221	1	phfs	phfs	ADV
fnp-3806	221	2	induce	induce	VERB
fnp-3806	221	3	tau	tau	PROPN
fnp-3806	221	4	accumulation	accumulation	NOUN
fnp-3806	221	5	into	into	ADP
fnp-3806	221	6	aggresomes	aggresome	NOUN
fnp-3806	221	7	that	that	PRON
fnp-3806	221	8	gather	gather	VERB
fnp-3806	221	9	misfolded	misfolde	VERB
fnp-3806	221	10	proteins	protein	NOUN
fnp-3806	221	11	when	when	SCONJ
fnp-3806	221	12	the	the	DET
fnp-3806	221	13	protein	protein	NOUN
fnp-3806	221	14	degradation	degradation	NOUN
fnp-3806	221	15	system	system	NOUN
fnp-3806	221	16	is	be	AUX
fnp-3806	221	17	overloaded	overload	VERB
fnp-3806	221	18	(	(	PUNCT
fnp-3806	221	19	216	216	NUM
fnp-3806	221	20	)	)	PUNCT
fnp-3806	221	21	.	.	PUNCT
fnp-3806	222	1	the	the	DET
fnp-3806	222	2	structure	structure	NOUN
fnp-3806	222	3	of	of	ADP
fnp-3806	222	4	tau	tau	PROPN
fnp-3806	222	5	filaments	filament	NOUN
fnp-3806	222	6	in	in	ADP
fnp-3806	222	7	the	the	DET
fnp-3806	222	8	different	different	ADJ
fnp-3806	222	9	tauopathies	tauopathie	NOUN
fnp-3806	222	10	largely	largely	ADV
fnp-3806	222	11	depends	depend	VERB
fnp-3806	222	12	on	on	ADP
fnp-3806	222	13	tau	tau	PROPN
fnp-3806	222	14	composition	composition	NOUN
fnp-3806	222	15	(	(	PUNCT
fnp-3806	222	16	3rtau	3rtau	NUM
fnp-3806	222	17	and	and	CCONJ
fnp-3806	222	18	4rtau	4rtau	NUM
fnp-3806	222	19	)	)	PUNCT
fnp-3806	222	20	and	and	CCONJ
fnp-3806	222	21	on	on	ADP
fnp-3806	222	22	post	post	ADJ
fnp-3806	222	23	-	-	ADJ
fnp-3806	222	24	translational	translational	ADJ
fnp-3806	222	25	modifications	modification	NOUN
fnp-3806	222	26	including	include	VERB
fnp-3806	222	27	conformation	conformation	NOUN
fnp-3806	222	28	and	and	CCONJ
fnp-3806	222	29	truncation	truncation	NOUN
fnp-3806	222	30	,	,	PUNCT
fnp-3806	222	31	as	as	SCONJ
fnp-3806	222	32	revealed	reveal	VERB
fnp-3806	222	33	by	by	ADP
fnp-3806	222	34	transmission	transmission	NOUN
fnp-3806	222	35	electron	electron	NOUN
fnp-3806	222	36	microscopy	microscopy	NOUN
fnp-3806	222	37	,	,	PUNCT
fnp-3806	222	38	and	and	CCONJ
fnp-3806	222	39	more	more	ADV
fnp-3806	222	40	recently	recently	ADV
fnp-3806	222	41	by	by	ADP
fnp-3806	222	42	optimized	optimize	VERB
fnp-3806	222	43	cryo	cryo	NOUN
fnp-3806	222	44	-	-	PUNCT
fnp-3806	222	45	electronmicroscopy	electronmicroscopy	NOUN
fnp-3806	222	46	and	and	CCONJ
fnp-3806	222	47	mass	mass	ADJ
fnp-3806	222	48	spectrometry	spectrometry	NOUN
fnp-3806	222	49	(	(	PUNCT
fnp-3806	222	50	193	193	NUM
fnp-3806	222	51	,	,	PUNCT
fnp-3806	222	52	217	217	NUM
fnp-3806	222	53	-	-	NUM
fnp-3806	222	54	222	222	NUM
fnp-3806	222	55	)	)	PUNCT
fnp-3806	222	56	.	.	PUNCT
fnp-3806	223	1	the	the	DET
fnp-3806	223	2	different	different	ADJ
fnp-3806	223	3	structure	structure	NOUN
fnp-3806	223	4	of	of	ADP
fnp-3806	223	5	tau	tau	PROPN
fnp-3806	223	6	aggregates	aggregate	NOUN
fnp-3806	223	7	in	in	ADP
fnp-3806	223	8	tauopathies	tauopathie	NOUN
fnp-3806	223	9	indicates	indicate	VERB
fnp-3806	223	10	the	the	DET
fnp-3806	223	11	formation	formation	NOUN
fnp-3806	223	12	of	of	ADP
fnp-3806	223	13	different	different	ADJ
fnp-3806	223	14	tau	tau	PROPN
fnp-3806	223	15	strains	strain	NOUN
fnp-3806	223	16	which	which	PRON
fnp-3806	223	17	are	be	AUX
fnp-3806	223	18	specific	specific	ADJ
fnp-3806	223	19	to	to	ADP
fnp-3806	223	20	each	each	DET
fnp-3806	223	21	tauopathy	tauopathy	NOUN
fnp-3806	223	22	(	(	PUNCT
fnp-3806	223	23	223	223	NUM
fnp-3806	223	24	)	)	PUNCT
fnp-3806	223	25	.	.	PUNCT
fnp-3806	224	1	the	the	DET
fnp-3806	224	2	accumulation	accumulation	NOUN
fnp-3806	224	3	rate	rate	NOUN
fnp-3806	224	4	of	of	ADP
fnp-3806	224	5	tau	tau	PROPN
fnp-3806	224	6	aggregates	aggregate	NOUN
fnp-3806	224	7	is	be	AUX
fnp-3806	224	8	greater	great	ADJ
fnp-3806	224	9	in	in	ADP
fnp-3806	224	10	females	female	NOUN
fnp-3806	224	11	and	and	CCONJ
fnp-3806	224	12	younger	young	ADJ
fnp-3806	224	13	β	β	NOUN
fnp-3806	224	14	-	-	ADJ
fnp-3806	224	15	amyloid	amyloid	NOUN
fnp-3806	224	16	-	-	PUNCT
fnp-3806	224	17	positive	positive	ADJ
fnp-3806	224	18	subjects	subject	NOUN
fnp-3806	224	19	(	(	PUNCT
fnp-3806	224	20	224	224	NUM
fnp-3806	224	21	)	)	PUNCT
fnp-3806	224	22	.	.	PUNCT
fnp-3806	225	1	increased	increase	VERB
fnp-3806	225	2	expression	expression	NOUN
fnp-3806	225	3	of	of	ADP
fnp-3806	225	4	19	19	NUM
fnp-3806	225	5	genes	gene	NOUN
fnp-3806	225	6	in	in	ADP
fnp-3806	225	7	chromosome	chromosome	NOUN
fnp-3806	225	8	x	x	PUNCT
fnp-3806	225	9	is	be	AUX
fnp-3806	225	10	associated	associate	VERB
fnp-3806	225	11	with	with	ADP
fnp-3806	225	12	tau	tau	PROPN
fnp-3806	225	13	burden	burden	NOUN
fnp-3806	225	14	and	and	CCONJ
fnp-3806	225	15	slower	slow	ADJ
fnp-3806	225	16	cognitive	cognitive	ADJ
fnp-3806	225	17	decline	decline	NOUN
fnp-3806	225	18	in	in	ADP
fnp-3806	225	19	women	woman	NOUN
fnp-3806	225	20	but	but	CCONJ
fnp-3806	225	21	not	not	PART
fnp-3806	225	22	in	in	ADP
fnp-3806	225	23	men	man	NOUN
fnp-3806	225	24	,	,	PUNCT
fnp-3806	225	25	suggesting	suggest	VERB
fnp-3806	225	26	that	that	PRON
fnp-3806	225	27	specific	specific	ADJ
fnp-3806	225	28	x	x	VERB
fnp-3806	225	29	chromosome	chromosome	NOUN
fnp-3806	225	30	factors	factor	NOUN
fnp-3806	225	31	could	could	AUX
fnp-3806	225	32	confer	confer	VERB
fnp-3806	225	33	risk	risk	NOUN
fnp-3806	225	34	or	or	CCONJ
fnp-3806	225	35	resilience	resilience	NOUN
fnp-3806	225	36	in	in	ADP
fnp-3806	225	37	aging	aging	NOUN
fnp-3806	225	38	and	and	CCONJ
fnp-3806	225	39	ad	ad	NOUN
fnp-3806	225	40	(	(	PUNCT
fnp-3806	225	41	225	225	NUM
fnp-3806	225	42	)	)	PUNCT
fnp-3806	225	43	.	.	PUNCT
fnp-3806	226	1	in	in	ADP
fnp-3806	226	2	addition	addition	NOUN
fnp-3806	226	3	to	to	ADP
fnp-3806	226	4	abnormal	abnormal	ADJ
fnp-3806	226	5	tau	tau	PROPN
fnp-3806	226	6	,	,	PUNCT
fnp-3806	226	7	nfts	nft	NOUN
fnp-3806	226	8	contain	contain	VERB
fnp-3806	226	9	numerous	numerous	ADJ
fnp-3806	226	10	proteins	protein	NOUN
fnp-3806	226	11	.	.	PUNCT
fnp-3806	227	1	total	total	ADJ
fnp-3806	227	2	tau	tau	PROPN
fnp-3806	227	3	interacts	interact	VERB
fnp-3806	227	4	with	with	ADP
fnp-3806	227	5	a	a	DET
fnp-3806	227	6	good	good	ADJ
fnp-3806	227	7	number	number	NOUN
fnp-3806	227	8	of	of	ADP
fnp-3806	227	9	proteins	protein	NOUN
fnp-3806	227	10	in	in	ADP
fnp-3806	227	11	ad	ad	NOUN
fnp-3806	227	12	(	(	PUNCT
fnp-3806	227	13	226	226	NUM
fnp-3806	227	14	,	,	PUNCT
fnp-3806	227	15	227	227	NUM
fnp-3806	227	16	)	)	PUNCT
fnp-3806	227	17	.	.	PUNCT
fnp-3806	228	1	laser	laser	NOUN
fnp-3806	228	2	-	-	PUNCT
fnp-3806	228	3	capture	capture	NOUN
fnp-3806	228	4	micro	micro	NOUN
fnp-3806	228	5	-	-	NOUN
fnp-3806	228	6	dissection	dissection	NOUN
fnp-3806	228	7	of	of	ADP
fnp-3806	228	8	nfts	nft	NOUN
fnp-3806	228	9	and	and	CCONJ
fnp-3806	228	10	liquid	liquid	ADJ
fnp-3806	228	11	chromatography-/tandem	chromatography-/tandem	NOUN
fnp-3806	228	12	mass	mass	PROPN
fnp-3806	228	13	spectrometry	spectrometry	NOUN
fnp-3806	228	14	(	(	PUNCT
fnp-3806	228	15	lc	lc	PROPN
fnp-3806	228	16	-	-	PUNCT
fnp-3806	228	17	ms	ms	PROPN
fnp-3806	228	18	/	/	SYM
fnp-3806	228	19	ms	ms	NOUN
fnp-3806	228	20	)	)	PUNCT
fnp-3806	228	21	analysis	analysis	NOUN
fnp-3806	228	22	in	in	ADP
fnp-3806	228	23	sad	sad	ADJ
fnp-3806	228	24	followed	follow	VERB
fnp-3806	228	25	by	by	ADP
fnp-3806	228	26	affinity	affinity	NOUN
fnp-3806	228	27	purification	purification	NOUN
fnp-3806	228	28	mass	mass	NOUN
fnp-3806	228	29	spectrometry	spectrometry	NOUN
fnp-3806	228	30	revealed	reveal	VERB
fnp-3806	228	31	that	that	SCONJ
fnp-3806	228	32	seventy	seventy	NUM
fnp-3806	228	33	-	-	PUNCT
fnp-3806	228	34	five	five	NUM
fnp-3806	228	35	proteins	protein	NOUN
fnp-3806	228	36	present	present	ADJ
fnp-3806	228	37	in	in	ADP
fnp-3806	228	38	nfts	nft	NOUN
fnp-3806	228	39	interacted	interact	VERB
fnp-3806	228	40	with	with	ADP
fnp-3806	228	41	phf1	phf1	NOUN
fnp-3806	228	42	-	-	PUNCT
fnp-3806	228	43	immunoreactive	immunoreactive	ADJ
fnp-3806	228	44	phosphorylated	phosphorylate	VERB
fnp-3806	228	45	tau	tau	PROPN
fnp-3806	228	46	(	(	PUNCT
fnp-3806	228	47	228	228	NUM
fnp-3806	228	48	)	)	PUNCT
fnp-3806	228	49	.	.	PUNCT
fnp-3806	229	1	nfts	nft	NOUN
fnp-3806	229	2	also	also	ADV
fnp-3806	229	3	contain	contain	VERB
fnp-3806	229	4	markers	marker	NOUN
fnp-3806	229	5	of	of	ADP
fnp-3806	229	6	the	the	DET
fnp-3806	229	7	sequestosome	sequestosome	NOUN
fnp-3806	229	8	/	/	SYM
fnp-3806	229	9	p62	p62	NOUN
fnp-3806	229	10	,	,	PUNCT
fnp-3806	229	11	ubiquitin	ubiquitin	NOUN
fnp-3806	229	12	,	,	PUNCT
fnp-3806	229	13	and	and	CCONJ
fnp-3806	229	14	mutant	mutant	ADJ
fnp-3806	229	15	ubiquitin	ubiquitin	NOUN
fnp-3806	229	16	(	(	PUNCT
fnp-3806	229	17	229	229	NUM
fnp-3806	229	18	,	,	PUNCT
fnp-3806	229	19	230	230	NUM
fnp-3806	229	20	)	)	PUNCT
fnp-3806	229	21	.	.	PUNCT
fnp-3806	230	1	increased	increase	VERB
fnp-3806	230	2	prpc	prpc	ADJ
fnp-3806	230	3	expression	expression	NOUN
fnp-3806	230	4	downregulates	downregulate	VERB
fnp-3806	230	5	tau	tau	PROPN
fnp-3806	230	6	protein	protein	NOUN
fnp-3806	230	7	(	(	PUNCT
fnp-3806	230	8	231	231	NUM
fnp-3806	230	9	-	-	SYM
fnp-3806	230	10	234	234	NUM
fnp-3806	230	11	)	)	PUNCT
fnp-3806	230	12	.	.	PUNCT
fnp-3806	231	1	conversely	conversely	ADV
fnp-3806	231	2	,	,	PUNCT
fnp-3806	231	3	reduction	reduction	NOUN
fnp-3806	231	4	or	or	CCONJ
fnp-3806	231	5	ablation	ablation	NOUN
fnp-3806	231	6	of	of	ADP
fnp-3806	231	7	prpc	prpc	NOUN
fnp-3806	231	8	levels	level	NOUN
fnp-3806	231	9	induces	induce	VERB
fnp-3806	231	10	an	an	DET
fnp-3806	231	11	increase	increase	NOUN
fnp-3806	231	12	in	in	ADP
fnp-3806	231	13	tau	tau	PROPN
fnp-3806	231	14	3rtau/4rtau	3rtau/4rtau	NUM
fnp-3806	231	15	balance	balance	NOUN
fnp-3806	231	16	through	through	ADP
fnp-3806	231	17	downregulation	downregulation	NOUN
fnp-3806	231	18	of	of	ADP
fnp-3806	231	19	gsk3β	gsk3β	PROPN
fnp-3806	231	20	activity	activity	NOUN
fnp-3806	231	21	,	,	PUNCT
fnp-3806	231	22	thus	thus	ADV
fnp-3806	231	23	indicating	indicate	VERB
fnp-3806	231	24	that	that	SCONJ
fnp-3806	231	25	prpc	prpc	NOUN
fnp-3806	231	26	plays	play	VERB
fnp-3806	231	27	a	a	DET
fnp-3806	231	28	role	role	NOUN
fnp-3806	231	29	in	in	ADP
fnp-3806	231	30	tau	tau	PROPN
fnp-3806	231	31	exon	exon	PROPN
fnp-3806	231	32	10	10	NUM
fnp-3806	231	33	inclusion	inclusion	NOUN
fnp-3806	231	34	through	through	ADP
fnp-3806	231	35	the	the	DET
fnp-3806	231	36	inhibitory	inhibitory	ADJ
fnp-3806	231	37	capacity	capacity	NOUN
fnp-3806	231	38	of	of	ADP
fnp-3806	231	39	gsk3β	gsk3β	PROPN
fnp-3806	231	40	(	(	PUNCT
fnp-3806	231	41	235	235	NUM
fnp-3806	231	42	)	)	PUNCT
fnp-3806	231	43	.	.	PUNCT
fnp-3806	232	1	increased	increase	VERB
fnp-3806	232	2	prpc	prpc	ADJ
fnp-3806	232	3	levels	level	NOUN
fnp-3806	232	4	at	at	ADP
fnp-3806	232	5	early	early	ADJ
fnp-3806	232	6	and	and	CCONJ
fnp-3806	232	7	middle	middle	ADJ
fnp-3806	232	8	stages	stage	NOUN
fnp-3806	232	9	of	of	ADP
fnp-3806	232	10	nft	nft	PROPN
fnp-3806	232	11	pathology	pathology	PROPN
fnp-3806	232	12	yields	yield	VERB
fnp-3806	232	13	lower	low	ADJ
fnp-3806	232	14	tau	tau	PROPN
fnp-3806	232	15	and	and	CCONJ
fnp-3806	232	16	hosphor	hosphor	PROPN
fnp-3806	232	17	-	-	PUNCT
fnp-3806	232	18	tau	tau	PROPN
fnp-3806	232	19	.	.	PUNCT
fnp-3806	233	1	in	in	ADP
fnp-3806	233	2	contrast	contrast	NOUN
fnp-3806	233	3	,	,	PUNCT
fnp-3806	233	4	prpc	prpc	ADJ
fnp-3806	233	5	levels	level	NOUN
fnp-3806	233	6	decrease	decrease	VERB
fnp-3806	233	7	at	at	ADP
fnp-3806	233	8	advanced	advanced	ADJ
fnp-3806	233	9	stages	stage	NOUN
fnp-3806	233	10	of	of	ADP
fnp-3806	233	11	nft	nft	PROPN
fnp-3806	233	12	pathology	pathology	PROPN
fnp-3806	233	13	,	,	PUNCT
fnp-3806	233	14	which	which	PRON
fnp-3806	233	15	correlates	correlate	VERB
fnp-3806	233	16	with	with	ADP
fnp-3806	233	17	increased	increase	VERB
fnp-3806	233	18	amounts	amount	NOUN
fnp-3806	233	19	of	of	ADP
fnp-3806	233	20	tau	tau	PROPN
fnp-3806	233	21	and	and	CCONJ
fnp-3806	233	22	hosphor	hosphor	PROPN
fnp-3806	233	23	-	-	PUNCT
fnp-3806	233	24	tau	tau	PROPN
fnp-3806	233	25	.	.	PUNCT
fnp-3806	234	1	taken	take	VERB
fnp-3806	234	2	together	together	ADV
fnp-3806	234	3	,	,	PUNCT
fnp-3806	234	4	these	these	DET
fnp-3806	234	5	observations	observation	NOUN
fnp-3806	234	6	suggest	suggest	VERB
fnp-3806	234	7	a	a	DET
fnp-3806	234	8	protective	protective	ADJ
fnp-3806	234	9	role	role	NOUN
fnp-3806	234	10	for	for	ADP
fnp-3806	234	11	prpc	prpc	NOUN
fnp-3806	234	12	in	in	ADP
fnp-3806	234	13	early	early	ADJ
fnp-3806	234	14	stages	stage	NOUN
fnp-3806	234	15	of	of	ADP
fnp-3806	234	16	ad	ad	NOUN
fnp-3806	234	17	(	(	PUNCT
fnp-3806	234	18	236	236	NUM
fnp-3806	234	19	)	)	PUNCT
fnp-3806	234	20	.	.	PUNCT
fnp-3806	235	1	these	these	DET
fnp-3806	235	2	observations	observation	NOUN
fnp-3806	235	3	linking	link	VERB
fnp-3806	235	4	an	an	DET
fnp-3806	235	5	interaction	interaction	NOUN
fnp-3806	235	6	of	of	ADP
fnp-3806	235	7	prion	prion	NOUN
fnp-3806	235	8	protein	protein	NOUN
fnp-3806	235	9	and	and	CCONJ
fnp-3806	235	10	tau	tau	PROPN
fnp-3806	235	11	may	may	AUX
fnp-3806	235	12	have	have	VERB
fnp-3806	235	13	implications	implication	NOUN
fnp-3806	235	14	in	in	ADP
fnp-3806	235	15	certain	certain	ADJ
fnp-3806	235	16	familial	familial	ADJ
fnp-3806	235	17	prion	prion	NOUN
fnp-3806	235	18	diseases	disease	NOUN
fnp-3806	235	19	grouped	group	VERB
fnp-3806	235	20	under	under	ADP
fnp-3806	235	21	the	the	DET
fnp-3806	235	22	term	term	NOUN
fnp-3806	235	23	gerstmann	gerstmann	NOUN
fnp-3806	235	24	-	-	PUNCT
fnp-3806	235	25	sträussler	sträussler	NOUN
fnp-3806	235	26	-	-	PUNCT
fnp-3806	235	27	scheinker	scheinker	NOUN
fnp-3806	235	28	disease	disease	NOUN
fnp-3806	235	29	,	,	PUNCT
fnp-3806	235	30	in	in	ADP
fnp-3806	235	31	which	which	PRON
fnp-3806	235	32	abundant	abundant	ADJ
fnp-3806	235	33	prpres	prpre	NOUN
fnp-3806	235	34	-	-	PUNCT
fnp-3806	235	35	amyloid	amyloid	NOUN
fnp-3806	235	36	deposits	deposit	NOUN
fnp-3806	235	37	are	be	AUX
fnp-3806	235	38	accompanied	accompany	VERB
fnp-3806	235	39	by	by	ADP
fnp-3806	235	40	extensive	extensive	ADJ
fnp-3806	235	41	tau	tau	PROPN
fnp-3806	235	42	pathology	pathology	NOUN
fnp-3806	235	43	(	(	PUNCT
fnp-3806	235	44	see	see	VERB
fnp-3806	235	45	section	section	NOUN
fnp-3806	235	46	3	3	NUM
fnp-3806	235	47	)	)	PUNCT
fnp-3806	235	48	.	.	PUNCT
fnp-3806	236	1	3	3	X
fnp-3806	236	2	.	.	X
fnp-3806	236	3	familial	familial	ADJ
fnp-3806	236	4	ad	ad	NOUN
fnp-3806	236	5	(	(	PUNCT
fnp-3806	236	6	fad	fad	NOUN
fnp-3806	236	7	;	;	PUNCT
fnp-3806	236	8	early	early	ADJ
fnp-3806	236	9	-	-	PUNCT
fnp-3806	236	10	onset	onset	NOUN
fnp-3806	236	11	familial	familial	ADJ
fnp-3806	236	12	alzheimer	alzheimer	PROPN
fnp-3806	236	13	’s	’s	PART
fnp-3806	236	14	disease	disease	NOUN
fnp-3806	236	15	:	:	PUNCT
fnp-3806	236	16	eofad	eofad	NOUN
fnp-3806	236	17	)	)	PUNCT
fnp-3806	236	18	,	,	PUNCT
fnp-3806	236	19	and	and	CCONJ
fnp-3806	236	20	the	the	DET
fnp-3806	236	21	β	β	NOUN
fnp-3806	236	22	-	-	ADJ
fnp-3806	236	23	amyloid	amyloid	ADJ
fnp-3806	236	24	cascade	cascade	NOUN
fnp-3806	236	25	hypothesis	hypothesis	NOUN
fnp-3806	236	26	from	from	ADP
fnp-3806	236	27	the	the	DET
fnp-3806	236	28	early	early	ADJ
fnp-3806	236	29	nineties	ninety	NOUN
fnp-3806	236	30	,	,	PUNCT
fnp-3806	236	31	mutations	mutation	NOUN
fnp-3806	236	32	in	in	ADP
fnp-3806	236	33	the	the	DET
fnp-3806	236	34	genes	gene	NOUN
fnp-3806	236	35	app	app	NOUN
fnp-3806	236	36	(	(	PUNCT
fnp-3806	236	37	β	β	NOUN
fnp-3806	236	38	-	-	ADJ
fnp-3806	236	39	amyloid	amyloid	ADJ
fnp-3806	236	40	precursor	precursor	NOUN
fnp-3806	236	41	protein	protein	NOUN
fnp-3806	236	42	)	)	PUNCT
fnp-3806	236	43	,	,	PUNCT
fnp-3806	236	44	psen1	psen1	ADJ
fnp-3806	236	45	(	(	PUNCT
fnp-3806	236	46	presenilin1	presenilin1	NOUN
fnp-3806	236	47	)	)	PUNCT
fnp-3806	236	48	,	,	PUNCT
fnp-3806	236	49	and	and	CCONJ
fnp-3806	236	50	psen2	psen2	NOUN
fnp-3806	236	51	(	(	PUNCT
fnp-3806	236	52	presenilin2	presenilin2	NOUN
fnp-3806	236	53	)	)	PUNCT
fnp-3806	236	54	,	,	PUNCT
fnp-3806	236	55	all	all	PRON
fnp-3806	236	56	of	of	ADP
fnp-3806	236	57	them	they	PRON
fnp-3806	236	58	involved	involve	VERB
fnp-3806	236	59	in	in	ADP
fnp-3806	236	60	the	the	DET
fnp-3806	236	61	production	production	NOUN
fnp-3806	236	62	of	of	ADP
fnp-3806	236	63	β	β	NOUN
fnp-3806	236	64	-	-	NOUN
fnp-3806	236	65	amyloid	amyloid	NOUN
fnp-3806	236	66	,	,	PUNCT
fnp-3806	236	67	have	have	AUX
fnp-3806	236	68	been	be	AUX
fnp-3806	236	69	identified	identify	VERB
fnp-3806	236	70	in	in	ADP
fnp-3806	236	71	several	several	ADJ
fnp-3806	236	72	families	family	NOUN
fnp-3806	236	73	with	with	ADP
fnp-3806	236	74	pre	pre	ADJ
fnp-3806	236	75	-	-	ADJ
fnp-3806	236	76	senile	senile	ADJ
fnp-3806	236	77	dementia	dementia	NOUN
fnp-3806	236	78	of	of	ADP
fnp-3806	236	79	alzheimer	alzheimer	PROPN
fnp-3806	236	80	’s	’s	PART
fnp-3806	236	81	type	type	NOUN
fnp-3806	236	82	(	(	PUNCT
fnp-3806	236	83	early	early	ADJ
fnp-3806	236	84	-	-	PUNCT
fnp-3806	236	85	onset	onset	NOUN
fnp-3806	236	86	familial	familial	ADJ
fnp-3806	236	87	alzheimer	alzheimer	NOUN
fnp-3806	236	88	disease	disease	NOUN
fnp-3806	236	89	:	:	PUNCT
fnp-3806	236	90	eofad	eofad	NOUN
fnp-3806	236	91	,	,	PUNCT
fnp-3806	236	92	or	or	CCONJ
fnp-3806	236	93	fad	fad	NOUN
fnp-3806	236	94	)	)	PUNCT
fnp-3806	236	95	;	;	PUNCT
fnp-3806	236	96	increased	increase	VERB
fnp-3806	236	97	app	app	NOUN
fnp-3806	236	98	dosage	dosage	NOUN
fnp-3806	236	99	was	be	AUX
fnp-3806	236	100	also	also	ADV
fnp-3806	236	101	causative	causative	ADJ
fnp-3806	236	102	of	of	ADP
fnp-3806	236	103	ad	ad	NOUN
fnp-3806	236	104	and	and	CCONJ
fnp-3806	236	105	β	β	NOUN
fnp-3806	236	106	-	-	NOUN
fnp-3806	236	107	amyloid	amyloid	ADJ
fnp-3806	236	108	angiopathy	angiopathy	NOUN
fnp-3806	236	109	(	(	PUNCT
fnp-3806	236	110	237	237	NUM
fnp-3806	236	111	-	-	SYM
fnp-3806	236	112	244	244	NUM
fnp-3806	236	113	)	)	PUNCT
fnp-3806	236	114	.	.	PUNCT
fnp-3806	237	1	recent	recent	ADJ
fnp-3806	237	2	genetic	genetic	ADJ
fnp-3806	237	3	studies	study	NOUN
fnp-3806	237	4	of	of	ADP
fnp-3806	237	5	the	the	DET
fnp-3806	237	6	first	first	PROPN
fnp-3806	237	7	alzheimer	alzheimer	PROPN
fnp-3806	237	8	’s	’s	PART
fnp-3806	237	9	case	case	NOUN
fnp-3806	237	10	identified	identify	VERB
fnp-3806	237	11	that	that	SCONJ
fnp-3806	237	12	the	the	DET
fnp-3806	237	13	patient	patient	NOUN
fnp-3806	237	14	carried	carry	VERB
fnp-3806	237	15	a	a	DET
fnp-3806	237	16	mutation	mutation	NOUN
fnp-3806	237	17	in	in	ADP
fnp-3806	237	18	psen1	psen1	ADJ
fnp-3806	237	19	.	.	PUNCT
fnp-3806	238	1	these	these	DET
fnp-3806	238	2	groundbreaking	groundbreake	VERB
fnp-3806	238	3	discoveries	discovery	NOUN
fnp-3806	238	4	led	lead	VERB
fnp-3806	238	5	to	to	ADP
fnp-3806	238	6	the	the	DET
fnp-3806	238	7	“	"	PUNCT
fnp-3806	238	8	β	β	NOUN
fnp-3806	238	9	-	-	ADJ
fnp-3806	238	10	amyloid	amyloid	ADJ
fnp-3806	238	11	cascade	cascade	NOUN
fnp-3806	238	12	hypothesis	hypothesis	NOUN
fnp-3806	238	13	”	"	PUNCT
fnp-3806	238	14	,	,	PUNCT
fnp-3806	238	15	which	which	PRON
fnp-3806	238	16	supports	support	VERB
fnp-3806	238	17	the	the	DET
fnp-3806	238	18	idea	idea	NOUN
fnp-3806	238	19	that	that	SCONJ
fnp-3806	238	20	the	the	DET
fnp-3806	238	21	production	production	NOUN
fnp-3806	238	22	of	of	ADP
fnp-3806	238	23	β	β	NOUN
fnp-3806	238	24	-	-	ADJ
fnp-3806	238	25	amyloid	amyloid	ADJ
fnp-3806	238	26	species	specie	NOUN
fnp-3806	238	27	is	be	AUX
fnp-3806	238	28	the	the	DET
fnp-3806	238	29	primary	primary	ADJ
fnp-3806	238	30	factor	factor	NOUN
fnp-3806	238	31	triggering	trigger	VERB
fnp-3806	238	32	nft	nft	PROPN
fnp-3806	238	33	formation	formation	NOUN
fnp-3806	238	34	and	and	CCONJ
fnp-3806	238	35	ad	ad	NOUN
fnp-3806	238	36	progression	progression	NOUN
fnp-3806	238	37	(	(	PUNCT
fnp-3806	238	38	245	245	NUM
fnp-3806	238	39	)	)	PUNCT
fnp-3806	238	40	.	.	PUNCT
fnp-3806	239	1	the	the	DET
fnp-3806	239	2	amyloid	amyloid	NOUN
fnp-3806	239	3	cascade	cascade	NOUN
fnp-3806	239	4	hypothesis	hypothesis	NOUN
fnp-3806	239	5	was	be	AUX
fnp-3806	239	6	further	far	ADV
fnp-3806	239	7	supported	support	VERB
fnp-3806	239	8	by	by	ADP
fnp-3806	239	9	the	the	DET
fnp-3806	239	10	production	production	NOUN
fnp-3806	239	11	of	of	ADP
fnp-3806	239	12	β	β	NOUN
fnp-3806	239	13	-	-	NOUN
fnp-3806	239	14	amyloid	amyloid	NOUN
fnp-3806	239	15	in	in	ADP
fnp-3806	239	16	transgenic	transgenic	NOUN
fnp-3806	239	17	mice	mouse	NOUN
fnp-3806	239	18	bearing	bear	VERB
fnp-3806	239	19	human	human	ADJ
fnp-3806	239	20	mutations	mutation	NOUN
fnp-3806	239	21	causative	causative	ADJ
fnp-3806	239	22	of	of	ADP
fnp-3806	239	23	ad	ad	NOUN
fnp-3806	239	24	.	.	PUNCT
fnp-3806	240	1	yet	yet	CCONJ
fnp-3806	240	2	mutations	mutation	NOUN
fnp-3806	240	3	in	in	ADP
fnp-3806	240	4	these	these	DET
fnp-3806	240	5	genes	gene	NOUN
fnp-3806	240	6	did	do	AUX
fnp-3806	240	7	not	not	PART
fnp-3806	240	8	result	result	VERB
fnp-3806	240	9	in	in	ADP
fnp-3806	240	10	nft	nft	PROPN
fnp-3806	240	11	formation	formation	NOUN
fnp-3806	240	12	in	in	ADP
fnp-3806	240	13	transgenic	transgenic	NOUN
fnp-3806	240	14	mice	mouse	NOUN
fnp-3806	240	15	,	,	PUNCT
fnp-3806	240	16	although	although	SCONJ
fnp-3806	240	17	a	a	DET
fnp-3806	240	18	few	few	ADJ
fnp-3806	240	19	small	small	ADJ
fnp-3806	240	20	hyper	hyper	ADV
fnp-3806	240	21	-	-	ADJ
fnp-3806	240	22	phosphorylated	phosphorylate	VERB
fnp-3806	240	23	tau	tau	NOUN
fnp-3806	240	24	deposits	deposit	NOUN
fnp-3806	240	25	did	do	AUX
fnp-3806	240	26	appear	appear	VERB
fnp-3806	240	27	in	in	ADP
fnp-3806	240	28	dystrophic	dystrophic	ADJ
fnp-3806	240	29	neurites	neurite	NOUN
fnp-3806	240	30	around	around	ADP
fnp-3806	240	31	β	β	NOUN
fnp-3806	240	32	-	-	NOUN
fnp-3806	240	33	amyloid	amyloid	ADJ
fnp-3806	240	34	plaques	plaque	NOUN
fnp-3806	240	35	.	.	PUNCT
fnp-3806	241	1	at	at	ADP
fnp-3806	241	2	most	most	ADV
fnp-3806	241	3	,	,	PUNCT
fnp-3806	241	4	the	the	DET
fnp-3806	241	5	joint	joint	ADJ
fnp-3806	241	6	production	production	NOUN
fnp-3806	241	7	of	of	ADP
fnp-3806	241	8	sps	sps	PROPN
fnp-3806	241	9	and	and	CCONJ
fnp-3806	241	10	tau	tau	PROPN
fnp-3806	241	11	deposits	deposit	VERB
fnp-3806	241	12	similar	similar	ADJ
fnp-3806	241	13	to	to	ADP
fnp-3806	241	14	nfts	nft	NOUN
fnp-3806	241	15	in	in	ADP
fnp-3806	241	16	mice	mouse	NOUN
fnp-3806	241	17	requires	require	VERB
fnp-3806	241	18	the	the	DET
fnp-3806	241	19	cumulative	cumulative	ADJ
fnp-3806	241	20	expression	expression	NOUN
fnp-3806	241	21	of	of	ADP
fnp-3806	241	22	different	different	ADJ
fnp-3806	241	23	mutated	mutate	VERB
fnp-3806	241	24	genes	gene	NOUN
fnp-3806	241	25	involved	involve	VERB
fnp-3806	241	26	in	in	ADP
fnp-3806	241	27	human	human	ADJ
fnp-3806	241	28	ad	ad	NOUN
fnp-3806	241	29	and	and	CCONJ
fnp-3806	241	30	tauopathies	tauopathie	NOUN
fnp-3806	241	31	(	(	PUNCT
fnp-3806	241	32	246	246	NUM
fnp-3806	241	33	-	-	SYM
fnp-3806	241	34	248	248	NUM
fnp-3806	241	35	)	)	PUNCT
fnp-3806	241	36	.	.	PUNCT
fnp-3806	242	1	however	however	ADV
fnp-3806	242	2	,	,	PUNCT
fnp-3806	242	3	in	in	ADP
fnp-3806	242	4	vitro	vitro	X
fnp-3806	242	5	and	and	CCONJ
fnp-3806	242	6	in	in	ADP
fnp-3806	242	7	vivo	vivo	ADJ
fnp-3806	242	8	studies	study	NOUN
fnp-3806	242	9	have	have	AUX
fnp-3806	242	10	shown	show	VERB
fnp-3806	242	11	the	the	DET
fnp-3806	242	12	capacity	capacity	NOUN
fnp-3806	242	13	of	of	ADP
fnp-3806	242	14	β	β	NOUN
fnp-3806	242	15	-	-	NOUN
fnp-3806	242	16	amyloid	amyloid	NOUN
fnp-3806	242	17	to	to	PART
fnp-3806	242	18	phosphorylate	phosphorylate	VERB
fnp-3806	242	19	tau	tau	PROPN
fnp-3806	242	20	and	and	CCONJ
fnp-3806	242	21	enhance	enhance	VERB
fnp-3806	242	22	tau	tau	PROPN
fnp-3806	242	23	aggregation	aggregation	NOUN
fnp-3806	242	24	,	,	PUNCT
fnp-3806	242	25	thus	thus	ADV
fnp-3806	242	26	giving	give	VERB
fnp-3806	242	27	a	a	DET
fnp-3806	242	28	boost	boost	NOUN
fnp-3806	242	29	to	to	ADP
fnp-3806	242	30	the	the	DET
fnp-3806	242	31	β	β	NOUN
fnp-3806	242	32	-	-	ADJ
fnp-3806	242	33	amyloid	amyloid	ADJ
fnp-3806	242	34	cascade	cascade	NOUN
fnp-3806	242	35	hypothesis	hypothesis	NOUN
fnp-3806	242	36	(	(	PUNCT
fnp-3806	242	37	249	249	NUM
fnp-3806	242	38	)	)	PUNCT
fnp-3806	242	39	.	.	PUNCT
fnp-3806	243	1	the	the	DET
fnp-3806	243	2	β	β	NOUN
fnp-3806	243	3	-	-	ADJ
fnp-3806	243	4	amyloid	amyloid	ADJ
fnp-3806	243	5	cascade	cascade	NOUN
fnp-3806	243	6	hypothesis	hypothesis	NOUN
fnp-3806	243	7	fits	fit	VERB
fnp-3806	243	8	with	with	ADP
fnp-3806	243	9	fad	fad	NOUN
fnp-3806	243	10	linked	link	VERB
fnp-3806	243	11	to	to	ADP
fnp-3806	243	12	mutations	mutation	NOUN
fnp-3806	243	13	of	of	ADP
fnp-3806	243	14	app	app	NOUN
fnp-3806	243	15	,	,	PUNCT
fnp-3806	243	16	psen1	psen1	ADJ
fnp-3806	243	17	,	,	PUNCT
fnp-3806	243	18	and	and	CCONJ
fnp-3806	243	19	psen2	psen2	NOUN
fnp-3806	243	20	.	.	PUNCT
fnp-3806	244	1	another	another	DET
fnp-3806	244	2	genetic	genetic	ADJ
fnp-3806	244	3	condition	condition	NOUN
fnp-3806	244	4	linked	link	VERB
fnp-3806	244	5	to	to	ADP
fnp-3806	244	6	increased	increase	VERB
fnp-3806	244	7	risk	risk	NOUN
fnp-3806	244	8	of	of	ADP
fnp-3806	244	9	ad	ad	NOUN
fnp-3806	244	10	is	be	AUX
fnp-3806	244	11	down	down	ADP
fnp-3806	244	12	syndrome	syndrome	NOUN
fnp-3806	244	13	.	.	PUNCT
fnp-3806	245	1	middle	middle	ADJ
fnp-3806	245	2	-	-	PUNCT
fnp-3806	245	3	aged	aged	ADJ
fnp-3806	245	4	individuals	individual	NOUN
fnp-3806	245	5	(	(	PUNCT
fnp-3806	245	6	ma	ma	PROPN
fnp-3806	245	7	)	)	PUNCT
fnp-3806	245	8	with	with	ADP
fnp-3806	245	9	down	down	ADP
fnp-3806	245	10	syndrome	syndrome	NOUN
fnp-3806	245	11	have	have	VERB
fnp-3806	245	12	neuropathological	neuropathological	ADJ
fnp-3806	245	13	lesions	lesion	NOUN
fnp-3806	245	14	of	of	ADP
fnp-3806	245	15	ad	ad	NOUN
fnp-3806	245	16	.	.	PUNCT
fnp-3806	246	1	amyloid	amyloid	NOUN
fnp-3806	246	2	deposits	deposit	NOUN
fnp-3806	246	3	may	may	AUX
fnp-3806	246	4	start	start	VERB
fnp-3806	246	5	as	as	ADV
fnp-3806	246	6	early	early	ADV
fnp-3806	246	7	as	as	ADP
fnp-3806	246	8	12	12	NUM
fnp-3806	246	9	years	year	NOUN
fnp-3806	246	10	of	of	ADP
fnp-3806	246	11	age	age	NOUN
fnp-3806	246	12	and	and	CCONJ
fnp-3806	246	13	they	they	PRON
fnp-3806	246	14	are	be	AUX
fnp-3806	246	15	universal	universal	ADJ
fnp-3806	246	16	by	by	ADP
fnp-3806	246	17	the	the	DET
fnp-3806	246	18	age	age	NOUN
fnp-3806	246	19	of	of	ADP
fnp-3806	246	20	31	31	NUM
fnp-3806	246	21	.	.	PUNCT
fnp-3806	247	1	nfts	nft	NOUN
fnp-3806	247	2	appear	appear	VERB
fnp-3806	247	3	later	later	ADV
fnp-3806	247	4	in	in	ADP
fnp-3806	247	5	the	the	DET
fnp-3806	247	6	entorhinal	entorhinal	ADJ
fnp-3806	247	7	cortex	cortex	NOUN
fnp-3806	247	8	,	,	PUNCT
fnp-3806	247	9	hippocampus	hippocampus	NOUN
fnp-3806	247	10	,	,	PUNCT
fnp-3806	247	11	and	and	CCONJ
fnp-3806	247	12	neocortex	neocortex	NOUN
fnp-3806	247	13	(	(	PUNCT
fnp-3806	247	14	250	250	NUM
fnp-3806	247	15	-	-	SYM
fnp-3806	247	16	253	253	NUM
fnp-3806	247	17	)	)	PUNCT
fnp-3806	247	18	.	.	PUNCT
fnp-3806	248	1	the	the	DET
fnp-3806	248	2	discovery	discovery	NOUN
fnp-3806	248	3	of	of	ADP
fnp-3806	248	4	β	β	NOUN
fnp-3806	248	5	-	-	NOUN
fnp-3806	248	6	oligomers	oligomer	NOUN
fnp-3806	248	7	and	and	CCONJ
fnp-3806	248	8	cumulative	cumulative	ADJ
fnp-3806	248	9	evidence	evidence	NOUN
fnp-3806	248	10	of	of	ADP
fnp-3806	248	11	their	their	PRON
fnp-3806	248	12	toxicity	toxicity	NOUN
fnp-3806	248	13	has	have	AUX
fnp-3806	248	14	led	lead	VERB
fnp-3806	248	15	to	to	ADP
fnp-3806	248	16	modification	modification	NOUN
fnp-3806	248	17	of	of	ADP
fnp-3806	248	18	the	the	DET
fnp-3806	248	19	“	"	PUNCT
fnp-3806	248	20	β	β	NOUN
fnp-3806	248	21	-	-	ADJ
fnp-3806	248	22	amyloid	amyloid	ADJ
fnp-3806	248	23	cascade	cascade	NOUN
fnp-3806	248	24	”	"	PUNCT
fnp-3806	248	25	hypothesis	hypothesis	NOUN
fnp-3806	248	26	,	,	PUNCT
fnp-3806	248	27	leading	lead	VERB
fnp-3806	248	28	to	to	ADP
fnp-3806	248	29	the	the	DET
fnp-3806	248	30	“	"	PUNCT
fnp-3806	248	31	amyloid	amyloid	NOUN
fnp-3806	248	32	-	-	PUNCT
fnp-3806	248	33	β	β	X
fnp-3806	248	34	oligomer	oligomer	ADJ
fnp-3806	248	35	hypothesis	hypothesis	NOUN
fnp-3806	248	36	”	"	PUNCT
fnp-3806	248	37	(	(	PUNCT
fnp-3806	248	38	103	103	NUM
fnp-3806	248	39	-	-	SYM
fnp-3806	248	40	108	108	NUM
fnp-3806	248	41	)	)	PUNCT
fnp-3806	248	42	.	.	PUNCT
fnp-3806	249	1	according	accord	VERB
fnp-3806	249	2	to	to	ADP
fnp-3806	249	3	the	the	DET
fnp-3806	249	4	new	new	ADJ
fnp-3806	249	5	proposal	proposal	NOUN
fnp-3806	249	6	,	,	PUNCT
fnp-3806	249	7	it	it	PRON
fnp-3806	249	8	is	be	AUX
fnp-3806	249	9	not	not	PART
fnp-3806	249	10	the	the	DET
fnp-3806	249	11	presence	presence	NOUN
fnp-3806	249	12	of	of	ADP
fnp-3806	249	13	fibrillar	fibrillar	ADJ
fnp-3806	249	14	β	β	NOUN
fnp-3806	249	15	-	-	NOUN
fnp-3806	249	16	amyloid	amyloid	NOUN
fnp-3806	249	17	and	and	CCONJ
fnp-3806	249	18	deposition	deposition	NOUN
fnp-3806	249	19	into	into	ADP
fnp-3806	249	20	definite	definite	ADJ
fnp-3806	249	21	aggregates	aggregate	NOUN
fnp-3806	249	22	,	,	PUNCT
fnp-3806	249	23	but	but	CCONJ
fnp-3806	249	24	rather	rather	ADV
fnp-3806	249	25	soluble	soluble	ADJ
fnp-3806	249	26	β	β	NOUN
fnp-3806	249	27	-	-	NOUN
fnp-3806	249	28	oligomers	oligomer	NOUN
fnp-3806	249	29	that	that	PRON
fnp-3806	249	30	are	be	AUX
fnp-3806	249	31	causative	causative	ADJ
fnp-3806	249	32	of	of	ADP
fnp-3806	249	33	cell	cell	NOUN
fnp-3806	249	34	damage	damage	NOUN
fnp-3806	249	35	and	and	CCONJ
fnp-3806	249	36	that	that	PRON
fnp-3806	249	37	trigger	trigger	VERB
fnp-3806	249	38	the	the	DET
fnp-3806	249	39	process	process	NOUN
fnp-3806	249	40	of	of	ADP
fnp-3806	249	41	neurodegeneration	neurodegeneration	NOUN
fnp-3806	249	42	in	in	ADP
fnp-3806	249	43	ad	ad	NOUN
fnp-3806	249	44	(	(	PUNCT
fnp-3806	249	45	103	103	NUM
fnp-3806	249	46	-	-	SYM
fnp-3806	249	47	106	106	NUM
fnp-3806	249	48	,	,	PUNCT
fnp-3806	249	49	254	254	NUM
fnp-3806	249	50	-	-	SYM
fnp-3806	249	51	257	257	NUM
fnp-3806	249	52	)	)	PUNCT
fnp-3806	249	53	.	.	PUNCT
fnp-3806	250	1	however	however	ADV
fnp-3806	250	2	,	,	PUNCT
fnp-3806	250	3	several	several	ADJ
fnp-3806	250	4	points	point	NOUN
fnp-3806	250	5	are	be	AUX
fnp-3806	250	6	still	still	ADV
fnp-3806	250	7	obscure	obscure	ADJ
fnp-3806	250	8	.	.	PUNCT
fnp-3806	251	1	the	the	DET
fnp-3806	251	2	level	level	NOUN
fnp-3806	251	3	of	of	ADP
fnp-3806	251	4	insoluble	insoluble	ADJ
fnp-3806	251	5	aβ	aβ	NOUN
fnp-3806	251	6	rises	rise	NOUN
fnp-3806	251	7	with	with	ADP
fnp-3806	251	8	age	age	NOUN
fnp-3806	251	9	and	and	CCONJ
fnp-3806	251	10	is	be	AUX
fnp-3806	251	11	further	far	ADV
fnp-3806	251	12	increased	increase	VERB
fnp-3806	251	13	in	in	ADP
fnp-3806	251	14	ad	ad	NOUN
fnp-3806	251	15	whereas	whereas	SCONJ
fnp-3806	251	16	the	the	DET
fnp-3806	251	17	total	total	ADJ
fnp-3806	251	18	level	level	NOUN
fnp-3806	251	19	of	of	ADP
fnp-3806	251	20	aβ40	aβ40	PROPN
fnp-3806	251	21	in	in	ADP
fnp-3806	251	22	both	both	CCONJ
fnp-3806	251	23	soluble	soluble	ADJ
fnp-3806	251	24	and	and	CCONJ
fnp-3806	251	25	insoluble	insoluble	ADJ
fnp-3806	251	26	fractions	fraction	NOUN
fnp-3806	251	27	and	and	CCONJ
fnp-3806	251	28	the	the	DET
fnp-3806	251	29	level	level	NOUN
fnp-3806	251	30	of	of	ADP
fnp-3806	251	31	aβ42	aβ42	PROPN
fnp-3806	251	32	in	in	ADP
fnp-3806	251	33	the	the	DET
fnp-3806	251	34	soluble	soluble	ADJ
fnp-3806	251	35	fraction	fraction	NOUN
fnp-3806	251	36	decline	decline	NOUN
fnp-3806	251	37	with	with	ADP
fnp-3806	251	38	age	age	NOUN
fnp-3806	251	39	before	before	ADP
fnp-3806	251	40	about	about	ADV
fnp-3806	251	41	50	50	NUM
fnp-3806	251	42	years	year	NOUN
fnp-3806	251	43	.	.	PUNCT
fnp-3806	252	1	differential	differential	ADJ
fnp-3806	252	2	production	production	NOUN
fnp-3806	252	3	or	or	CCONJ
fnp-3806	252	4	retention	retention	NOUN
fnp-3806	252	5	of	of	ADP
fnp-3806	252	6	aβ40	aβ40	PROPN
fnp-3806	252	7	and	and	CCONJ
fnp-3806	252	8	aβ42	aβ42	PROPN
fnp-3806	252	9	likely	likely	ADV
fnp-3806	252	10	contributes	contribute	VERB
fnp-3806	252	11	to	to	ADP
fnp-3806	252	12	the	the	DET
fnp-3806	252	13	influence	influence	NOUN
fnp-3806	252	14	of	of	ADP
fnp-3806	252	15	age	age	NOUN
fnp-3806	252	16	on	on	ADP
fnp-3806	252	17	the	the	DET
fnp-3806	252	18	risk	risk	NOUN
fnp-3806	252	19	of	of	ADP
fnp-3806	252	20	sporadic	sporadic	ADJ
fnp-3806	252	21	ad	ad	NOUN
fnp-3806	252	22	,	,	PUNCT
fnp-3806	252	23	but	but	CCONJ
fnp-3806	252	24	the	the	DET
fnp-3806	252	25	levels	level	NOUN
fnp-3806	252	26	of	of	ADP
fnp-3806	252	27	soluble	soluble	ADJ
fnp-3806	252	28	aβ	aβ	NOUN
fnp-3806	252	29	concentrations	concentration	NOUN
fnp-3806	252	30	,	,	PUNCT
fnp-3806	252	31	higher	high	ADJ
fnp-3806	252	32	in	in	ADP
fnp-3806	252	33	young	young	ADJ
fnp-3806	252	34	adults	adult	NOUN
fnp-3806	252	35	than	than	ADP
fnp-3806	252	36	in	in	ADP
fnp-3806	252	37	older	old	ADJ
fnp-3806	252	38	individuals	individual	NOUN
fnp-3806	252	39	and	and	CCONJ
fnp-3806	252	40	in	in	ADP
fnp-3806	252	41	subjects	subject	NOUN
fnp-3806	252	42	with	with	ADP
fnp-3806	252	43	ad	ad	NOUN
fnp-3806	252	44	,	,	PUNCT
fnp-3806	252	45	do	do	AUX
fnp-3806	252	46	not	not	PART
fnp-3806	252	47	match	match	VERB
fnp-3806	252	48	the	the	DET
fnp-3806	252	49	proposed	propose	VERB
fnp-3806	252	50	toxic	toxic	ADJ
fnp-3806	252	51	role	role	NOUN
fnp-3806	252	52	of	of	ADP
fnp-3806	252	53	oligomers	oligomer	NOUN
fnp-3806	252	54	in	in	ADP
fnp-3806	252	55	ad	ad	NOUN
fnp-3806	252	56	(	(	PUNCT
fnp-3806	252	57	258	258	NUM
fnp-3806	252	58	,	,	PUNCT
fnp-3806	252	59	259	259	NUM
fnp-3806	252	60	)	)	PUNCT
fnp-3806	252	61	.	.	PUNCT
fnp-3806	253	1	tau	tau	PROPN
fnp-3806	253	2	deposits	deposit	NOUN
fnp-3806	253	3	,	,	PUNCT
fnp-3806	253	4	other	other	ADJ
fnp-3806	253	5	than	than	ADP
fnp-3806	253	6	those	those	PRON
fnp-3806	253	7	located	locate	VERB
fnp-3806	253	8	in	in	ADP
fnp-3806	253	9	dystrophic	dystrophic	ADJ
fnp-3806	253	10	neurites	neurite	NOUN
fnp-3806	253	11	of	of	ADP
fnp-3806	253	12	sps	sps	PROPN
fnp-3806	253	13	,	,	PUNCT
fnp-3806	253	14	are	be	AUX
fnp-3806	253	15	largely	largely	ADV
fnp-3806	253	16	independent	independent	ADJ
fnp-3806	253	17	of	of	ADP
fnp-3806	253	18	β	β	NOUN
fnp-3806	253	19	-	-	NOUN
fnp-3806	253	20	amyloid	amyloid	NOUN
fnp-3806	253	21	.	.	PUNCT
fnp-3806	254	1	other	other	ADJ
fnp-3806	254	2	factors	factor	NOUN
fnp-3806	254	3	,	,	PUNCT
fnp-3806	254	4	including	include	VERB
fnp-3806	254	5	apolipoprotein	apolipoprotein	ADJ
fnp-3806	254	6	e	e	PROPN
fnp-3806	254	7	(	(	PUNCT
fnp-3806	254	8	apoe	apoe	ADJ
fnp-3806	254	9	)	)	PUNCT
fnp-3806	254	10	,	,	PUNCT
fnp-3806	254	11	the	the	DET
fnp-3806	254	12	endocytic	endocytic	ADJ
fnp-3806	254	13	system	system	NOUN
fnp-3806	254	14	,	,	PUNCT
fnp-3806	254	15	cholesterol	cholesterol	NOUN
fnp-3806	254	16	metabolism	metabolism	NOUN
fnp-3806	254	17	,	,	PUNCT
fnp-3806	254	18	and	and	CCONJ
fnp-3806	254	19	microglial	microglial	ADJ
fnp-3806	254	20	activation	activation	NOUN
fnp-3806	254	21	,	,	PUNCT
fnp-3806	254	22	are	be	AUX
fnp-3806	254	23	regulators	regulator	NOUN
fnp-3806	254	24	of	of	ADP
fnp-3806	254	25	tau	tau	PROPN
fnp-3806	254	26	pathology	pathology	NOUN
fnp-3806	254	27	(	(	PUNCT
fnp-3806	254	28	260	260	NUM
fnp-3806	254	29	)	)	PUNCT
fnp-3806	254	30	.	.	PUNCT
fnp-3806	255	1	neurons	neuron	NOUN
fnp-3806	255	2	derived	derive	VERB
fnp-3806	255	3	from	from	ADP
fnp-3806	255	4	induced	induced	ADJ
fnp-3806	255	5	pluripotent	pluripotent	ADJ
fnp-3806	255	6	stem	stem	NOUN
fnp-3806	255	7	cell	cell	NOUN
fnp-3806	255	8	(	(	PUNCT
fnp-3806	255	9	ipsc	ipsc	NOUN
fnp-3806	255	10	)	)	PUNCT
fnp-3806	255	11	lines	line	NOUN
fnp-3806	255	12	from	from	ADP
fnp-3806	255	13	sad	sad	ADJ
fnp-3806	255	14	and	and	CCONJ
fnp-3806	255	15	fad	fad	NOUN
fnp-3806	255	16	linked	link	VERB
fnp-3806	255	17	to	to	ADP
fnp-3806	255	18	psen1	psen1	ADJ
fnp-3806	255	19	mutations	mutation	NOUN
fnp-3806	255	20	show	show	VERB
fnp-3806	255	21	increased	increase	VERB
fnp-3806	255	22	phosphorylation	phosphorylation	NOUN
fnp-3806	255	23	of	of	ADP
fnp-3806	255	24	tau	tau	PROPN
fnp-3806	255	25	at	at	ADP
fnp-3806	255	26	different	different	ADJ
fnp-3806	255	27	sites	site	NOUN
fnp-3806	255	28	,	,	PUNCT
fnp-3806	255	29	increased	increase	VERB
fnp-3806	255	30	levels	level	NOUN
fnp-3806	255	31	of	of	ADP
fnp-3806	255	32	active	active	ADJ
fnp-3806	255	33	gsk3β	gsk3β	PROPN
fnp-3806	255	34	,	,	PUNCT
fnp-3806	255	35	and	and	CCONJ
fnp-3806	255	36	a	a	DET
fnp-3806	255	37	significant	significant	ADJ
fnp-3806	255	38	upregulation	upregulation	NOUN
fnp-3806	255	39	of	of	ADP
fnp-3806	255	40	app	app	NOUN
fnp-3806	255	41	synthesis	synthesis	NOUN
fnp-3806	255	42	and	and	CCONJ
fnp-3806	255	43	app	app	NOUN
fnp-3806	255	44	carboxy	carboxy	ADJ
fnp-3806	255	45	-	-	PUNCT
fnp-3806	255	46	terminal	terminal	ADJ
fnp-3806	255	47	fragment	fragment	NOUN
fnp-3806	255	48	cleavage	cleavage	NOUN
fnp-3806	255	49	.	.	PUNCT
fnp-3806	256	1	however	however	ADV
fnp-3806	256	2	,	,	PUNCT
fnp-3806	256	3	significantly	significantly	ADV
fnp-3806	256	4	increased	increase	VERB
fnp-3806	256	5	aβ1	aβ1	NOUN
fnp-3806	256	6	-	-	PUNCT
fnp-3806	256	7	42	42	NUM
fnp-3806	256	8	/	/	SYM
fnp-3806	256	9	aβ1	aβ1	NOUN
fnp-3806	256	10	-	-	PUNCT
fnp-3806	256	11	40	40	NUM
fnp-3806	256	12	ratios	ratio	NOUN
fnp-3806	256	13	are	be	AUX
fnp-3806	256	14	observed	observe	VERB
fnp-3806	256	15	in	in	ADP
fnp-3806	256	16	fad	fad	NOUN
fnp-3806	256	17	but	but	CCONJ
fnp-3806	256	18	not	not	PART
fnp-3806	256	19	in	in	ADP
fnp-3806	256	20	sad	sad	ADJ
fnp-3806	256	21	(	(	PUNCT
fnp-3806	256	22	261	261	NUM
fnp-3806	256	23	)	)	PUNCT
fnp-3806	256	24	.	.	PUNCT
fnp-3806	257	1	other	other	ADJ
fnp-3806	257	2	amyloids	amyloid	NOUN
fnp-3806	257	3	are	be	AUX
fnp-3806	257	4	the	the	DET
fnp-3806	257	5	main	main	ADJ
fnp-3806	257	6	constituents	constituent	NOUN
fnp-3806	257	7	,	,	PUNCT
fnp-3806	257	8	in	in	ADP
fnp-3806	257	9	combination	combination	NOUN
fnp-3806	257	10	with	with	ADP
fnp-3806	257	11	nfts	nft	NOUN
fnp-3806	257	12	,	,	PUNCT
fnp-3806	257	13	of	of	ADP
fnp-3806	257	14	different	different	ADJ
fnp-3806	257	15	genetic	genetic	ADJ
fnp-3806	257	16	neurodegenerative	neurodegenerative	ADJ
fnp-3806	257	17	diseases	disease	NOUN
fnp-3806	257	18	causing	cause	VERB
fnp-3806	257	19	dementia	dementia	NOUN
fnp-3806	257	20	.	.	PUNCT
fnp-3806	258	1	familial	familial	ADJ
fnp-3806	258	2	british	british	ADJ
fnp-3806	258	3	dementia	dementia	NOUN
fnp-3806	258	4	(	(	PUNCT
fnp-3806	258	5	fbd	fbd	PROPN
fnp-3806	258	6	)	)	PUNCT
fnp-3806	258	7	and	and	CCONJ
fnp-3806	258	8	familial	familial	ADJ
fnp-3806	258	9	danish	danish	ADJ
fnp-3806	258	10	dementia	dementia	NOUN
fnp-3806	258	11	(	(	PUNCT
fnp-3806	258	12	fdd	fdd	PROPN
fnp-3806	258	13	)	)	PUNCT
fnp-3806	258	14	are	be	AUX
fnp-3806	258	15	linked	link	VERB
fnp-3806	258	16	to	to	ADP
fnp-3806	258	17	specific	specific	ADJ
fnp-3806	258	18	mutations	mutation	NOUN
fnp-3806	258	19	in	in	ADP
fnp-3806	258	20	the	the	DET
fnp-3806	258	21	bri2	bri2	NOUN
fnp-3806	258	22	gene	gene	NOUN
fnp-3806	258	23	;	;	PUNCT
fnp-3806	258	24	the	the	DET
fnp-3806	258	25	cleavage	cleavage	NOUN
fnp-3806	258	26	of	of	ADP
fnp-3806	258	27	integral	integral	ADJ
fnp-3806	258	28	membrane	membrane	NOUN
fnp-3806	258	29	protein	protein	NOUN
fnp-3806	258	30	2b	2b	NOUN
fnp-3806	258	31	(	(	PUNCT
fnp-3806	258	32	bri2	bri2	PROPN
fnp-3806	258	33	)	)	PUNCT
fnp-3806	258	34	produces	produce	VERB
fnp-3806	258	35	abri	abri	PROPN
fnp-3806	258	36	and	and	CCONJ
fnp-3806	258	37	adan	adan	PROPN
fnp-3806	258	38	amyloidogenic	amyloidogenic	ADJ
fnp-3806	258	39	peptides	peptide	NOUN
fnp-3806	258	40	,	,	PUNCT
fnp-3806	258	41	respectively	respectively	ADV
fnp-3806	258	42	.	.	PUNCT
fnp-3806	259	1	amyloid	amyloid	NOUN
fnp-3806	259	2	plaques	plaque	NOUN
fnp-3806	259	3	and	and	CCONJ
fnp-3806	259	4	amyloid	amyloid	NOUN
fnp-3806	259	5	angiopathy	angiopathy	ADJ
fnp-3806	259	6	,	,	PUNCT
fnp-3806	259	7	and	and	CCONJ
fnp-3806	259	8	nfts	nft	NOUN
fnp-3806	259	9	with	with	ADP
fnp-3806	259	10	a	a	DET
fnp-3806	259	11	tau	tau	PROPN
fnp-3806	259	12	composition	composition	NOUN
fnp-3806	259	13	identical	identical	ADJ
fnp-3806	259	14	to	to	ADP
fnp-3806	259	15	ad	ad	PROPN
fnp-3806	259	16	tau	tau	PROPN
fnp-3806	259	17	,	,	PUNCT
fnp-3806	259	18	are	be	AUX
fnp-3806	259	19	found	find	VERB
fnp-3806	259	20	in	in	ADP
fnp-3806	259	21	both	both	DET
fnp-3806	259	22	diseases	disease	NOUN
fnp-3806	259	23	(	(	PUNCT
fnp-3806	259	24	262	262	NUM
fnp-3806	259	25	,	,	PUNCT
fnp-3806	259	26	263	263	NUM
fnp-3806	259	27	)	)	PUNCT
fnp-3806	259	28	.	.	PUNCT
fnp-3806	260	1	gerstmann	gerstmann	PROPN
fnp-3806	260	2	-	-	PUNCT
fnp-3806	260	3	sträussler	sträussler	NOUN
fnp-3806	260	4	-	-	PUNCT
fnp-3806	260	5	scheinker	scheinker	NOUN
fnp-3806	260	6	disease	disease	NOUN
fnp-3806	260	7	(	(	PUNCT
fnp-3806	260	8	gss	gss	PROPN
fnp-3806	260	9	)	)	PUNCT
fnp-3806	260	10	is	be	AUX
fnp-3806	260	11	linked	link	VERB
fnp-3806	260	12	to	to	ADP
fnp-3806	260	13	mutations	mutation	NOUN
fnp-3806	260	14	in	in	ADP
fnp-3806	260	15	the	the	DET
fnp-3806	260	16	prion	prion	NOUN
fnp-3806	260	17	protein	protein	NOUN
fnp-3806	260	18	gene	gene	NOUN
fnp-3806	260	19	(	(	PUNCT
fnp-3806	260	20	prnp	prnp	PROPN
fnp-3806	260	21	)	)	PUNCT
fnp-3806	260	22	that	that	PRON
fnp-3806	260	23	cause	cause	VERB
fnp-3806	260	24	a	a	DET
fnp-3806	260	25	prionopathy	prionopathy	NOUN
fnp-3806	260	26	.	.	PUNCT
fnp-3806	261	1	depending	depend	VERB
fnp-3806	261	2	on	on	ADP
fnp-3806	261	3	the	the	DET
fnp-3806	261	4	muta	muta	PROPN
fnp-3806	261	5	-	-	PUNCT
fnp-3806	261	6	tion	tion	NOUN
fnp-3806	261	7	,	,	PUNCT
fnp-3806	261	8	gss	gss	PROPN
fnp-3806	261	9	is	be	AUX
fnp-3806	261	10	manifested	manifest	VERB
fnp-3806	261	11	pathologically	pathologically	ADV
fnp-3806	261	12	by	by	ADP
fnp-3806	261	13	a	a	DET
fnp-3806	261	14	combination	combination	NOUN
fnp-3806	261	15	of	of	ADP
fnp-3806	261	16	abundant	abundant	ADJ
fnp-3806	261	17	prion	prion	NOUN
fnp-3806	261	18	-	-	PUNCT
fnp-3806	261	19	immunoreactive	immunoreactive	ADJ
fnp-3806	261	20	plaques	plaque	NOUN
fnp-3806	261	21	surrounded	surround	VERB
fnp-3806	261	22	by	by	ADP
fnp-3806	261	23	dystrophic	dystrophic	ADJ
fnp-3806	261	24	neurites	neurite	NOUN
fnp-3806	261	25	,	,	PUNCT
fnp-3806	261	26	together	together	ADV
fnp-3806	261	27	with	with	ADP
fnp-3806	261	28	numerous	numerous	ADJ
fnp-3806	261	29	nfts	nft	NOUN
fnp-3806	261	30	indistinguishable	indistinguishable	ADJ
fnp-3806	261	31	from	from	ADP
fnp-3806	261	32	ad	ad	NOUN
fnp-3806	261	33	-	-	PUNCT
fnp-3806	261	34	nfts	nft	NOUN
fnp-3806	261	35	(	(	PUNCT
fnp-3806	261	36	264	264	NUM
fnp-3806	261	37	-	-	SYM
fnp-3806	261	38	266	266	NUM
fnp-3806	261	39	)	)	PUNCT
fnp-3806	261	40	.	.	PUNCT
fnp-3806	262	1	interestingly	interestingly	ADV
fnp-3806	262	2	,	,	PUNCT
fnp-3806	262	3	app	app	PROPN
fnp-3806	262	4	,	,	PUNCT
fnp-3806	262	5	bri2	bri2	NOUN
fnp-3806	262	6	,	,	PUNCT
fnp-3806	262	7	and	and	CCONJ
fnp-3806	262	8	prion	prion	NOUN
fnp-3806	262	9	are	be	AUX
fnp-3806	262	10	proteins	protein	NOUN
fnp-3806	262	11	located	locate	VERB
fnp-3806	262	12	at	at	ADP
fnp-3806	262	13	the	the	DET
fnp-3806	262	14	cell	cell	NOUN
fnp-3806	262	15	membrane	membrane	NOUN
fnp-3806	262	16	,	,	PUNCT
fnp-3806	262	17	and	and	CCONJ
fnp-3806	262	18	they	they	PRON
fnp-3806	262	19	interact	interact	VERB
fnp-3806	262	20	with	with	ADP
fnp-3806	262	21	each	each	DET
fnp-3806	262	22	other	other	ADJ
fnp-3806	262	23	in	in	ADP
fnp-3806	262	24	normal	normal	ADJ
fnp-3806	262	25	conditions	condition	NOUN
fnp-3806	262	26	.	.	PUNCT
fnp-3806	263	1	the	the	DET
fnp-3806	263	2	non	non	ADJ
fnp-3806	263	3	-	-	ADJ
fnp-3806	263	4	fibrillar	fibrillar	ADJ
fnp-3806	263	5	,	,	PUNCT
fnp-3806	263	6	soluble	soluble	ADJ
fnp-3806	263	7	bri2	bri2	NOUN
fnp-3806	263	8	-	-	PUNCT
fnp-3806	263	9	derived	derive	VERB
fnp-3806	263	10	amyloids	amyloid	NOUN
fnp-3806	263	11	are	be	AUX
fnp-3806	263	12	also	also	ADV
fnp-3806	263	13	toxic	toxic	ADJ
fnp-3806	263	14	,	,	PUNCT
fnp-3806	263	15	and	and	CCONJ
fnp-3806	263	16	probably	probably	ADV
fnp-3806	263	17	play	play	VERB
fnp-3806	263	18	a	a	DET
fnp-3806	263	19	central	central	ADJ
fnp-3806	263	20	role	role	NOUN
fnp-3806	263	21	in	in	ADP
fnp-3806	263	22	the	the	DET
fnp-3806	263	23	pathogenesis	pathogenesis	NOUN
fnp-3806	263	24	of	of	ADP
fnp-3806	263	25	bri2	bri2	PROPN
fnp-3806	263	26	-	-	PUNCT
fnp-3806	263	27	linked	link	VERB
fnp-3806	263	28	dementias	dementia	NOUN
fnp-3806	263	29	(	(	PUNCT
fnp-3806	263	30	267	267	NUM
fnp-3806	263	31	)	)	PUNCT
fnp-3806	263	32	.	.	PUNCT
fnp-3806	264	1	the	the	DET
fnp-3806	264	2	common	common	ADJ
fnp-3806	264	3	structure	structure	NOUN
fnp-3806	264	4	of	of	ADP
fnp-3806	264	5	soluble	soluble	ADJ
fnp-3806	264	6	amyloid	amyloid	NOUN
fnp-3806	264	7	oligomers	oligomer	NOUN
fnp-3806	264	8	suggests	suggest	VERB
fnp-3806	264	9	a	a	DET
fnp-3806	264	10	common	common	ADJ
fnp-3806	264	11	mechanism	mechanism	NOUN
fnp-3806	264	12	of	of	ADP
fnp-3806	264	13	pathogenesis	pathogenesis	NOUN
fnp-3806	264	14	(	(	PUNCT
fnp-3806	264	15	109	109	NUM
fnp-3806	264	16	,	,	PUNCT
fnp-3806	264	17	113	113	NUM
fnp-3806	264	18	)	)	PUNCT
fnp-3806	264	19	.	.	PUNCT
fnp-3806	265	1	despite	despite	SCONJ
fnp-3806	265	2	the	the	DET
fnp-3806	265	3	differing	differ	VERB
fnp-3806	265	4	genetic	genetic	ADJ
fnp-3806	265	5	nature	nature	NOUN
fnp-3806	265	6	of	of	ADP
fnp-3806	265	7	these	these	DET
fnp-3806	265	8	disorders	disorder	NOUN
fnp-3806	265	9	,	,	PUNCT
fnp-3806	265	10	plaques	plaque	NOUN
fnp-3806	265	11	and	and	CCONJ
fnp-3806	265	12	nfts	nft	NOUN
fnp-3806	265	13	do	do	AUX
fnp-3806	265	14	not	not	PART
fnp-3806	265	15	appear	appear	VERB
fnp-3806	265	16	until	until	ADP
fnp-3806	265	17	middle	middle	ADJ
fnp-3806	265	18	age	age	NOUN
fnp-3806	265	19	.	.	PUNCT
fnp-3806	266	1	understanding	understanding	NOUN
fnp-3806	266	2	of	of	ADP
fnp-3806	266	3	the	the	DET
fnp-3806	266	4	mechanisms	mechanism	NOUN
fnp-3806	266	5	that	that	PRON
fnp-3806	266	6	control	control	VERB
fnp-3806	266	7	the	the	DET
fnp-3806	266	8	metabolic	metabolic	NOUN
fnp-3806	266	9	pathways	pathway	NOUN
fnp-3806	266	10	,	,	PUNCT
fnp-3806	266	11	that	that	PRON
fnp-3806	266	12	delay	delay	VERB
fnp-3806	266	13	the	the	DET
fnp-3806	266	14	beginning	beginning	NOUN
fnp-3806	266	15	of	of	ADP
fnp-3806	266	16	the	the	DET
fnp-3806	266	17	molecular	molecular	ADJ
fnp-3806	266	18	and	and	CCONJ
fnp-3806	266	19	clinical	clinical	ADJ
fnp-3806	266	20	manifestations	manifestation	NOUN
fnp-3806	266	21	of	of	ADP
fnp-3806	266	22	the	the	DET
fnp-3806	266	23	disease	disease	NOUN
fnp-3806	266	24	for	for	ADP
fnp-3806	266	25	years	year	NOUN
fnp-3806	266	26	,	,	PUNCT
fnp-3806	266	27	is	be	AUX
fnp-3806	266	28	a	a	DET
fnp-3806	266	29	major	major	ADJ
fnp-3806	266	30	challenge	challenge	NOUN
fnp-3806	266	31	in	in	ADP
fnp-3806	266	32	neurodegenerative	neurodegenerative	ADJ
fnp-3806	266	33	diseases	disease	NOUN
fnp-3806	266	34	linked	link	VERB
fnp-3806	266	35	to	to	ADP
fnp-3806	266	36	mutations	mutation	NOUN
fnp-3806	266	37	in	in	ADP
fnp-3806	266	38	specific	specific	ADJ
fnp-3806	266	39	genes	gene	NOUN
fnp-3806	266	40	.	.	PUNCT
fnp-3806	267	1	in	in	ADP
fnp-3806	267	2	contrast	contrast	NOUN
fnp-3806	267	3	to	to	ADP
fnp-3806	267	4	mutations	mutation	NOUN
fnp-3806	267	5	linked	link	VERB
fnp-3806	267	6	to	to	ADP
fnp-3806	267	7	β	β	NOUN
fnp-3806	267	8	-	-	NOUN
fnp-3806	267	9	amyloid	amyloid	ADJ
fnp-3806	267	10	production	production	NOUN
fnp-3806	267	11	,	,	PUNCT
fnp-3806	267	12	mutations	mutation	NOUN
fnp-3806	267	13	in	in	ADP
fnp-3806	267	14	mapt	mapt	NOUN
fnp-3806	267	15	are	be	AUX
fnp-3806	267	16	causative	causative	ADJ
fnp-3806	267	17	of	of	ADP
fnp-3806	267	18	familial	familial	ADJ
fnp-3806	267	19	tauopathy	tauopathy	NOUN
fnp-3806	267	20	and	and	CCONJ
fnp-3806	267	21	are	be	AUX
fnp-3806	267	22	never	never	ADV
fnp-3806	267	23	associated	associate	VERB
fnp-3806	267	24	with	with	ADP
fnp-3806	267	25	β	β	NOUN
fnp-3806	267	26	-	-	NOUN
fnp-3806	267	27	amyloid	amyloid	NOUN
fnp-3806	267	28	or	or	CCONJ
fnp-3806	267	29	other	other	ADJ
fnp-3806	267	30	amyloid	amyloid	NOUN
fnp-3806	267	31	deposits	deposit	NOUN
fnp-3806	267	32	(	(	PUNCT
fnp-3806	267	33	170	170	NUM
fnp-3806	267	34	,	,	PUNCT
fnp-3806	267	35	171	171	NUM
fnp-3806	267	36	)	)	PUNCT
fnp-3806	267	37	.	.	PUNCT
fnp-3806	268	1	4	4	X
fnp-3806	268	2	.	.	X
fnp-3806	268	3	sporadic	sporadic	ADJ
fnp-3806	268	4	ad	ad	NOUN
fnp-3806	268	5	(	(	PUNCT
fnp-3806	268	6	sad	sad	ADJ
fnp-3806	268	7	;	;	PUNCT
fnp-3806	268	8	late	late	ADJ
fnp-3806	268	9	-	-	PUNCT
fnp-3806	268	10	onset	onset	NOUN
fnp-3806	268	11	alzheimer	alzheimer	NOUN
fnp-3806	268	12	disease	disease	NOUN
fnp-3806	268	13	:	:	PUNCT
fnp-3806	268	14	load	load	NOUN
fnp-3806	268	15	)	)	PUNCT
fnp-3806	268	16	most	most	ADJ
fnp-3806	268	17	cases	case	NOUN
fnp-3806	268	18	of	of	ADP
fnp-3806	268	19	ad	ad	NOUN
fnp-3806	268	20	(	(	PUNCT
fnp-3806	268	21	more	more	ADJ
fnp-3806	268	22	than	than	ADP
fnp-3806	268	23	95	95	NUM
fnp-3806	268	24	%	%	NOUN
fnp-3806	268	25	)	)	PUNCT
fnp-3806	268	26	are	be	AUX
fnp-3806	268	27	sporadic	sporadic	ADJ
fnp-3806	268	28	(	(	PUNCT
fnp-3806	268	29	sad	sad	ADJ
fnp-3806	268	30	)	)	PUNCT
fnp-3806	268	31	and	and	CCONJ
fnp-3806	268	32	occur	occur	VERB
fnp-3806	268	33	in	in	ADP
fnp-3806	268	34	older	old	ADJ
fnp-3806	268	35	individuals	individual	NOUN
fnp-3806	268	36	(	(	PUNCT
fnp-3806	268	37	late	late	ADJ
fnp-3806	268	38	-	-	PUNCT
fnp-3806	268	39	onset	onset	NOUN
fnp-3806	268	40	alzheimer	alzheimer	PROPN
fnp-3806	268	41	’s	’s	PART
fnp-3806	268	42	disease	disease	NOUN
fnp-3806	268	43	:	:	PUNCT
fnp-3806	268	44	load	load	NOUN
fnp-3806	268	45	)	)	PUNCT
fnp-3806	268	46	.	.	PUNCT
fnp-3806	269	1	sad	sad	ADJ
fnp-3806	269	2	has	have	VERB
fnp-3806	269	3	an	an	DET
fnp-3806	269	4	insidious	insidious	ADJ
fnp-3806	269	5	onset	onset	NOUN
fnp-3806	269	6	and	and	CCONJ
fnp-3806	269	7	a	a	DET
fnp-3806	269	8	progressive	progressive	ADJ
fnp-3806	269	9	course	course	NOUN
fnp-3806	269	10	leading	lead	VERB
fnp-3806	269	11	to	to	ADP
fnp-3806	269	12	death	death	NOUN
fnp-3806	269	13	about	about	ADV
fnp-3806	269	14	10	10	NUM
fnp-3806	269	15	-	-	SYM
fnp-3806	269	16	15	15	NUM
fnp-3806	269	17	years	year	NOUN
fnp-3806	269	18	after	after	ADP
fnp-3806	269	19	the	the	DET
fnp-3806	269	20	first	first	ADJ
fnp-3806	269	21	clinical	clinical	ADJ
fnp-3806	269	22	symptoms	symptom	NOUN
fnp-3806	269	23	of	of	ADP
fnp-3806	269	24	dementia	dementia	NOUN
fnp-3806	269	25	.	.	PUNCT
fnp-3806	270	1	aging	aging	NOUN
fnp-3806	270	2	is	be	AUX
fnp-3806	270	3	the	the	DET
fnp-3806	270	4	main	main	ADJ
fnp-3806	270	5	contributory	contributory	NOUN
fnp-3806	270	6	factor	factor	NOUN
fnp-3806	270	7	.	.	PUNCT
fnp-3806	271	1	sad	sad	ADJ
fnp-3806	271	2	is	be	AUX
fnp-3806	271	3	favoured	favour	VERB
fnp-3806	271	4	by	by	ADP
fnp-3806	271	5	individual	individual	ADJ
fnp-3806	271	6	or	or	CCONJ
fnp-3806	271	7	combined	combine	VERB
fnp-3806	271	8	low	low	ADJ
fnp-3806	271	9	penetrating	penetrate	VERB
fnp-3806	271	10	genetic	genetic	ADJ
fnp-3806	271	11	factors	factor	NOUN
fnp-3806	271	12	,	,	PUNCT
fnp-3806	271	13	mainly	mainly	ADV
fnp-3806	271	14	allele	allele	PROPN
fnp-3806	271	15	ε4	ε4	PROPN
fnp-3806	271	16	of	of	ADP
fnp-3806	271	17	apoe	apoe	PROPN
fnp-3806	271	18	(	(	PUNCT
fnp-3806	271	19	268	268	NUM
fnp-3806	271	20	-	-	NUM
fnp-3806	271	21	271	271	NUM
fnp-3806	271	22	)	)	PUNCT
fnp-3806	271	23	.	.	PUNCT
fnp-3806	272	1	genome	genome	NOUN
fnp-3806	272	2	-	-	PUNCT
fnp-3806	272	3	wide	wide	ADJ
fnp-3806	272	4	association	association	NOUN
fnp-3806	272	5	studies	study	NOUN
fnp-3806	272	6	(	(	PUNCT
fnp-3806	272	7	gwas	gwas	PROPN
fnp-3806	272	8	)	)	PUNCT
fnp-3806	272	9	have	have	AUX
fnp-3806	272	10	identified	identify	VERB
fnp-3806	272	11	other	other	ADJ
fnp-3806	272	12	risk	risk	NOUN
fnp-3806	272	13	genes	gene	NOUN
fnp-3806	272	14	of	of	ADP
fnp-3806	272	15	sad	sad	ADJ
fnp-3806	272	16	:	:	PUNCT
fnp-3806	272	17	ldl	ldl	NOUN
fnp-3806	272	18	receptor	receptor	NOUN
fnp-3806	272	19	related	relate	VERB
fnp-3806	272	20	protein	protein	NOUN
fnp-3806	272	21	1	1	NUM
fnp-3806	272	22	(	(	PUNCT
fnp-3806	272	23	lrp1	lrp1	PROPN
fnp-3806	272	24	)	)	PUNCT
fnp-3806	272	25	;	;	PUNCT
fnp-3806	272	26	low	low	ADJ
fnp-3806	272	27	density	density	NOUN
fnp-3806	272	28	lipoprotein	lipoprotein	ADJ
fnp-3806	272	29	protein	protein	NOUN
fnp-3806	272	30	receptor	receptor	NOUN
fnp-3806	272	31	1	1	NUM
fnp-3806	272	32	(	(	PUNCT
fnp-3806	272	33	ldlr	ldlr	PROPN
fnp-3806	272	34	)	)	PUNCT
fnp-3806	272	35	;	;	PUNCT
fnp-3806	272	36	interleukin	interleukin	NOUN
fnp-3806	272	37	1a	1a	NOUN
fnp-3806	272	38	;	;	PUNCT
fnp-3806	273	1	clusterin	clusterin	NOUN
fnp-3806	273	2	(	(	PUNCT
fnp-3806	273	3	clu	clu	PROPN
fnp-3806	273	4	)	)	PUNCT
fnp-3806	273	5	;	;	PUNCT
fnp-3806	273	6	phosphatidylinositol	phosphatidylinositol	NOUN
fnp-3806	273	7	binding	bind	VERB
fnp-3806	273	8	clathrin	clathrin	NOUN
fnp-3806	273	9	assembly	assembly	NOUN
fnp-3806	273	10	protein	protein	NOUN
fnp-3806	273	11	(	(	PUNCT
fnp-3806	273	12	picalm	picalm	ADJ
fnp-3806	273	13	)	)	PUNCT
fnp-3806	273	14	;	;	PUNCT
fnp-3806	273	15	complement	complement	NOUN
fnp-3806	273	16	component	component	NOUN
fnp-3806	273	17	(	(	PUNCT
fnp-3806	273	18	3b/4b	3b/4b	NUM
fnp-3806	273	19	)	)	PUNCT
fnp-3806	273	20	receptor	receptor	NOUN
fnp-3806	273	21	1	1	NUM
fnp-3806	273	22	(	(	PUNCT
fnp-3806	273	23	cr1	cr1	PROPN
fnp-3806	273	24	)	)	PUNCT
fnp-3806	273	25	;	;	PUNCT
fnp-3806	273	26	bridging	bridge	VERB
fnp-3806	273	27	integrator	integrator	NOUN
fnp-3806	273	28	1	1	NUM
fnp-3806	273	29	(	(	PUNCT
fnp-3806	273	30	bin1	bin1	PROPN
fnp-3806	273	31	)	)	PUNCT
fnp-3806	273	32	,	,	PUNCT
fnp-3806	273	33	involved	involve	VERB
fnp-3806	273	34	in	in	ADP
fnp-3806	273	35	synaptic	synaptic	ADJ
fnp-3806	273	36	vesicles	vesicle	NOUN
fnp-3806	273	37	and	and	CCONJ
fnp-3806	273	38	endocytosis	endocytosis	NOUN
fnp-3806	273	39	;	;	PUNCT
fnp-3806	273	40	triggering	trigger	VERB
fnp-3806	273	41	receptor	receptor	NOUN
fnp-3806	273	42	expressed	express	VERB
fnp-3806	273	43	on	on	ADP
fnp-3806	273	44	myeloid	myeloid	ADJ
fnp-3806	273	45	cells	cell	NOUN
fnp-3806	273	46	2	2	NUM
fnp-3806	273	47	(	(	PUNCT
fnp-3806	273	48	trem2	trem2	NOUN
fnp-3806	273	49	)	)	PUNCT
fnp-3806	273	50	;	;	PUNCT
fnp-3806	273	51	sortilin	sortilin	PROPN
fnp-3806	273	52	-	-	PUNCT
fnp-3806	273	53	related	relate	VERB
fnp-3806	273	54	receptor	receptor	NOUN
fnp-3806	273	55	1	1	NUM
fnp-3806	273	56	(	(	PUNCT
fnp-3806	273	57	sorl1	sorl1	PROPN
fnp-3806	273	58	)	)	PUNCT
fnp-3806	273	59	,	,	PUNCT
fnp-3806	273	60	involved	involve	VERB
fnp-3806	273	61	in	in	ADP
fnp-3806	273	62	endocytosis	endocytosis	NOUN
fnp-3806	273	63	and	and	CCONJ
fnp-3806	273	64	sorting	sorting	NOUN
fnp-3806	273	65	;	;	PUNCT
fnp-3806	273	66	adam	adam	PROPN
fnp-3806	273	67	metallopeptidase	metallopeptidase	PROPN
fnp-3806	273	68	domain	domain	NOUN
fnp-3806	273	69	10	10	NUM
fnp-3806	273	70	(	(	PUNCT
fnp-3806	273	71	adam10	adam10	X
fnp-3806	273	72	)	)	PUNCT
fnp-3806	273	73	,	,	PUNCT
fnp-3806	273	74	involved	involve	VERB
fnp-3806	273	75	in	in	ADP
fnp-3806	273	76	the	the	DET
fnp-3806	273	77	cleavage	cleavage	NOUN
fnp-3806	273	78	of	of	ADP
fnp-3806	273	79	several	several	ADJ
fnp-3806	273	80	proteins	protein	NOUN
fnp-3806	273	81	;	;	PUNCT
fnp-3806	273	82	atp	atp	NOUN
fnp-3806	273	83	binding	bind	VERB
fnp-3806	273	84	cassette	cassette	NOUN
fnp-3806	273	85	subfamily	subfamily	ADV
fnp-3806	273	86	a	a	DET
fnp-3806	273	87	member	member	NOUN
fnp-3806	273	88	7	7	NUM
fnp-3806	273	89	(	(	PUNCT
fnp-3806	273	90	abca7	abca7	PROPN
fnp-3806	273	91	)	)	PUNCT
fnp-3806	273	92	;	;	PUNCT
fnp-3806	273	93	spi-1	spi-1	NUM
fnp-3806	273	94	proto	proto	NOUN
fnp-3806	273	95	-	-	PUNCT
fnp-3806	273	96	oncogene	oncogene	NOUN
fnp-3806	273	97	(	(	PUNCT
fnp-3806	273	98	spi1	spi1	PROPN
fnp-3806	273	99	)	)	PUNCT
fnp-3806	273	100	;	;	PUNCT
fnp-3806	273	101	paired	pair	VERB
fnp-3806	273	102	immunoglobin	immunoglobin	NOUN
fnp-3806	273	103	like	like	ADP
fnp-3806	273	104	type	type	NOUN
fnp-3806	273	105	2	2	NUM
fnp-3806	273	106	receptor	receptor	NOUN
fnp-3806	273	107	alpha	alpha	NOUN
fnp-3806	273	108	(	(	PUNCT
fnp-3806	273	109	pilra	pilra	NOUN
fnp-3806	273	110	)	)	PUNCT
fnp-3806	273	111	;	;	PUNCT
fnp-3806	273	112	membrane	membrane	NOUN
fnp-3806	273	113	-	-	PUNCT
fnp-3806	273	114	spanning	span	VERB
fnp-3806	273	115	4	4	NUM
fnp-3806	273	116	-	-	PUNCT
fnp-3806	273	117	domains	domain	NOUN
fnp-3806	273	118	subfamily	subfamily	ADV
fnp-3806	273	119	a	a	PRON
fnp-3806	273	120	(	(	PUNCT
fnp-3806	273	121	msa4	msa4	PROPN
fnp-3806	273	122	)	)	PUNCT
fnp-3806	273	123	,	,	PUNCT
fnp-3806	273	124	linked	link	VERB
fnp-3806	273	125	to	to	ADP
fnp-3806	273	126	inflammation	inflammation	NOUN
fnp-3806	273	127	;	;	PUNCT
fnp-3806	273	128	cd2	cd2	PROPN
fnp-3806	273	129	-	-	PUNCT
fnp-3806	273	130	associated	associate	VERB
fnp-3806	273	131	protein	protein	NOUN
fnp-3806	273	132	(	(	PUNCT
fnp-3806	273	133	cd2ap	cd2ap	NOUN
fnp-3806	273	134	)	)	PUNCT
fnp-3806	273	135	that	that	PRON
fnp-3806	273	136	regulates	regulate	VERB
fnp-3806	273	137	actin	actin	NOUN
fnp-3806	273	138	cytoskeleton	cytoskeleton	PROPN
fnp-3806	273	139	;	;	PUNCT
fnp-3806	273	140	and	and	CCONJ
fnp-3806	273	141	ephrin	ephrin	ADJ
fnp-3806	273	142	receptor	receptor	NOUN
fnp-3806	273	143	a1	a1	NOUN
fnp-3806	273	144	(	(	PUNCT
fnp-3806	273	145	epha1	epha1	PROPN
fnp-3806	273	146	)	)	PUNCT
fnp-3806	273	147	,	,	PUNCT
fnp-3806	273	148	among	among	ADP
fnp-3806	273	149	others	other	NOUN
fnp-3806	273	150	(	(	PUNCT
fnp-3806	273	151	272	272	NUM
fnp-3806	273	152	-	-	SYM
fnp-3806	273	153	288	288	NUM
fnp-3806	273	154	)	)	PUNCT
fnp-3806	273	155	.	.	PUNCT
fnp-3806	274	1	the	the	DET
fnp-3806	274	2	regional	regional	ADJ
fnp-3806	274	3	and	and	CCONJ
fnp-3806	274	4	areal	areal	VERB
fnp-3806	274	5	distribution	distribution	NOUN
fnp-3806	274	6	of	of	ADP
fnp-3806	274	7	nfts	nft	NOUN
fnp-3806	274	8	and	and	CCONJ
fnp-3806	274	9	sps	sps	NOUN
fnp-3806	274	10	in	in	ADP
fnp-3806	274	11	the	the	DET
fnp-3806	274	12	cerebral	cerebral	ADJ
fnp-3806	274	13	cortex	cortex	NOUN
fnp-3806	274	14	is	be	AUX
fnp-3806	274	15	not	not	PART
fnp-3806	274	16	homogeneous	homogeneous	ADJ
fnp-3806	274	17	.	.	PUNCT
fnp-3806	275	1	in	in	ADP
fnp-3806	275	2	the	the	DET
fnp-3806	275	3	hippocampal	hippocampal	ADJ
fnp-3806	275	4	complex	complex	NOUN
fnp-3806	275	5	,	,	PUNCT
fnp-3806	275	6	nfts	nft	NOUN
fnp-3806	275	7	predominate	predominate	ADJ
fnp-3806	275	8	in	in	ADP
fnp-3806	275	9	the	the	DET
fnp-3806	275	10	ca1	ca1	PROPN
fnp-3806	275	11	region	region	NOUN
fnp-3806	275	12	and	and	CCONJ
fnp-3806	275	13	subiculum	subiculum	NOUN
fnp-3806	275	14	,	,	PUNCT
fnp-3806	275	15	the	the	DET
fnp-3806	275	16	ca2	ca2	PROPN
fnp-3806	275	17	,	,	PUNCT
fnp-3806	275	18	ca3	ca3	PROPN
fnp-3806	275	19	and	and	CCONJ
fnp-3806	275	20	hilus	hilus	NOUN
fnp-3806	275	21	are	be	AUX
fnp-3806	275	22	less	less	ADV
fnp-3806	275	23	affected	affected	ADJ
fnp-3806	275	24	,	,	PUNCT
fnp-3806	275	25	and	and	CCONJ
fnp-3806	275	26	the	the	DET
fnp-3806	275	27	dentate	dentate	ADJ
fnp-3806	275	28	gyrus	gyrus	NOUN
fnp-3806	275	29	is	be	AUX
fnp-3806	275	30	spared	spare	VERB
fnp-3806	275	31	in	in	ADP
fnp-3806	275	32	pure	pure	ADJ
fnp-3806	275	33	sad	sad	ADJ
fnp-3806	275	34	cases	case	NOUN
fnp-3806	275	35	.	.	PUNCT
fnp-3806	276	1	in	in	ADP
fnp-3806	276	2	the	the	DET
fnp-3806	276	3	entorhinal	entorhinal	ADJ
fnp-3806	276	4	cortex	cortex	NOUN
fnp-3806	276	5	,	,	PUNCT
fnp-3806	276	6	nfts	nft	NOUN
fnp-3806	276	7	are	be	AUX
fnp-3806	276	8	more	more	ADV
fnp-3806	276	9	abundant	abundant	ADJ
fnp-3806	276	10	in	in	ADP
fnp-3806	276	11	layers	layer	NOUN
fnp-3806	276	12	ii	ii	PROPN
fnp-3806	276	13	and	and	CCONJ
fnp-3806	276	14	v	v	ADP
fnp-3806	276	15	,	,	PUNCT
fnp-3806	276	16	whereas	whereas	SCONJ
fnp-3806	276	17	in	in	ADP
fnp-3806	276	18	the	the	DET
fnp-3806	276	19	neocortex	neocortex	NOUN
fnp-3806	276	20	,	,	PUNCT
fnp-3806	276	21	nfts	nft	NOUN
fnp-3806	276	22	predominate	predominate	ADJ
fnp-3806	276	23	in	in	ADP
fnp-3806	276	24	layers	layer	NOUN
fnp-3806	276	25	iii	iii	PROPN
fnp-3806	276	26	and	and	CCONJ
fnp-3806	276	27	v	v	NOUN
fnp-3806	276	28	,	,	PUNCT
fnp-3806	276	29	with	with	ADP
fnp-3806	276	30	marked	mark	VERB
fnp-3806	276	31	regional	regional	ADJ
fnp-3806	276	32	variations	variation	NOUN
fnp-3806	276	33	(	(	PUNCT
fnp-3806	276	34	the	the	DET
fnp-3806	276	35	primary	primary	ADJ
fnp-3806	276	36	motor	motor	NOUN
fnp-3806	276	37	and	and	CCONJ
fnp-3806	276	38	sensory	sensory	ADJ
fnp-3806	276	39	cortices	cortex	NOUN
fnp-3806	276	40	have	have	VERB
fnp-3806	276	41	fewer	few	ADJ
fnp-3806	276	42	nfts	nft	NOUN
fnp-3806	276	43	than	than	ADP
fnp-3806	276	44	the	the	DET
fnp-3806	276	45	association	association	NOUN
fnp-3806	276	46	areas	area	NOUN
fnp-3806	276	47	)	)	PUNCT
fnp-3806	276	48	.	.	PUNCT
fnp-3806	277	1	nfts	nft	NOUN
fnp-3806	277	2	are	be	AUX
fnp-3806	277	3	found	find	VERB
fnp-3806	277	4	more	more	ADV
fnp-3806	277	5	abundant	abundant	ADJ
fnp-3806	277	6	in	in	ADP
fnp-3806	277	7	the	the	DET
fnp-3806	277	8	temporal	temporal	ADJ
fnp-3806	277	9	cortex	cortex	NOUN
fnp-3806	277	10	,	,	PUNCT
fnp-3806	277	11	followed	follow	VERB
fnp-3806	277	12	by	by	ADP
fnp-3806	277	13	the	the	DET
fnp-3806	277	14	frontal	frontal	ADJ
fnp-3806	277	15	and	and	CCONJ
fnp-3806	277	16	parietal	parietal	ADJ
fnp-3806	277	17	cortex	cortex	NOUN
fnp-3806	277	18	,	,	PUNCT
fnp-3806	277	19	and	and	CCONJ
fnp-3806	277	20	the	the	DET
fnp-3806	277	21	occipital	occipital	ADJ
fnp-3806	277	22	cortex	cortex	NOUN
fnp-3806	277	23	.	.	PUNCT
fnp-3806	278	1	in	in	ADP
fnp-3806	278	2	subcortical	subcortical	ADJ
fnp-3806	278	3	regions	region	NOUN
fnp-3806	278	4	,	,	PUNCT
fnp-3806	278	5	nfts	nft	NOUN
fnp-3806	278	6	are	be	AUX
fnp-3806	278	7	localized	localize	VERB
fnp-3806	278	8	in	in	ADP
fnp-3806	278	9	the	the	DET
fnp-3806	278	10	basal	basal	ADJ
fnp-3806	278	11	nucleus	nucleus	NOUN
fnp-3806	278	12	of	of	ADP
fnp-3806	278	13	meynert	meynert	PROPN
fnp-3806	278	14	and	and	CCONJ
fnp-3806	278	15	nuclei	nucleus	NOUN
fnp-3806	278	16	of	of	ADP
fnp-3806	278	17	the	the	DET
fnp-3806	278	18	basal	basal	ADJ
fnp-3806	278	19	forebrain	forebrain	NOUN
fnp-3806	278	20	,	,	PUNCT
fnp-3806	278	21	amygdala	amygdala	NOUN
fnp-3806	278	22	,	,	PUNCT
fnp-3806	278	23	hypothalamic	hypothalamic	ADJ
fnp-3806	278	24	nuclei	nucleus	NOUN
fnp-3806	278	25	,	,	PUNCT
fnp-3806	278	26	relay	relay	NOUN
fnp-3806	278	27	neurons	neuron	NOUN
fnp-3806	278	28	within	within	ADP
fnp-3806	278	29	intralaminar	intralaminar	NOUN
fnp-3806	278	30	and	and	CCONJ
fnp-3806	278	31	limbic	limbic	ADJ
fnp-3806	278	32	thalamic	thalamic	ADJ
fnp-3806	278	33	nuclei	nucleus	NOUN
fnp-3806	278	34	,	,	PUNCT
fnp-3806	278	35	ventral	ventral	ADJ
fnp-3806	278	36	tegmental	tegmental	ADJ
fnp-3806	278	37	area	area	NOUN
fnp-3806	278	38	,	,	PUNCT
fnp-3806	278	39	raphe	raphe	NOUN
fnp-3806	278	40	nuclei	nucleus	NOUN
fnp-3806	278	41	,	,	PUNCT
fnp-3806	278	42	locus	locus	NOUN
fnp-3806	278	43	ceruleus	ceruleus	NOUN
fnp-3806	278	44	,	,	PUNCT
fnp-3806	278	45	and	and	CCONJ
fnp-3806	278	46	olfactory	olfactory	ADJ
fnp-3806	278	47	bulb	bulb	NOUN
fnp-3806	278	48	.	.	PUNCT
fnp-3806	279	1	the	the	DET
fnp-3806	279	2	cerebellar	cerebellar	ADJ
fnp-3806	279	3	cortex	cortex	NOUN
fnp-3806	279	4	is	be	AUX
fnp-3806	279	5	spared	spare	VERB
fnp-3806	279	6	of	of	ADP
fnp-3806	279	7	nft	nft	PROPN
fnp-3806	279	8	pathology	pathology	PROPN
fnp-3806	279	9	.	.	PUNCT
fnp-3806	280	1	cortical	cortical	ADJ
fnp-3806	280	2	neurons	neuron	NOUN
fnp-3806	280	3	with	with	ADP
fnp-3806	280	4	nfts	nft	NOUN
fnp-3806	280	5	are	be	AUX
fnp-3806	280	6	mainly	mainly	ADV
fnp-3806	280	7	subpopulations	subpopulation	NOUN
fnp-3806	280	8	of	of	ADP
fnp-3806	280	9	large	large	ADJ
fnp-3806	280	10	pyramidal	pyramidal	ADJ
fnp-3806	280	11	glutamatergic	glutamatergic	ADJ
fnp-3806	280	12	neurons	neuron	NOUN
fnp-3806	280	13	(	(	PUNCT
fnp-3806	280	14	289	289	NUM
fnp-3806	280	15	-	-	SYM
fnp-3806	280	16	291	291	NUM
fnp-3806	280	17	)	)	PUNCT
fnp-3806	280	18	.	.	PUNCT
fnp-3806	281	1	this	this	PRON
fnp-3806	281	2	is	be	AUX
fnp-3806	281	3	consistent	consistent	ADJ
fnp-3806	281	4	with	with	ADP
fnp-3806	281	5	the	the	DET
fnp-3806	281	6	observation	observation	NOUN
fnp-3806	281	7	that	that	SCONJ
fnp-3806	281	8	neurons	neuron	NOUN
fnp-3806	281	9	with	with	ADP
fnp-3806	281	10	high	high	ADJ
fnp-3806	281	11	content	content	NOUN
fnp-3806	281	12	of	of	ADP
fnp-3806	281	13	neurofilaments	neurofilament	NOUN
fnp-3806	281	14	are	be	AUX
fnp-3806	281	15	more	more	ADV
fnp-3806	281	16	susceptible	susceptible	ADJ
fnp-3806	281	17	to	to	ADP
fnp-3806	281	18	nft	nft	PROPN
fnp-3806	281	19	formation	formation	NOUN
fnp-3806	281	20	(	(	PUNCT
fnp-3806	281	21	290	290	NUM
fnp-3806	281	22	-	-	SYM
fnp-3806	281	23	295	295	NUM
fnp-3806	281	24	)	)	PUNCT
fnp-3806	281	25	.	.	PUNCT
fnp-3806	282	1	gabaergic	gabaergic	ADJ
fnp-3806	282	2	neurons	neuron	NOUN
fnp-3806	282	3	are	be	AUX
fnp-3806	282	4	more	more	ADV
fnp-3806	282	5	resistant	resistant	ADJ
fnp-3806	282	6	to	to	ADP
fnp-3806	282	7	nft	nft	PROPN
fnp-3806	282	8	pathology	pathology	PROPN
fnp-3806	282	9	,	,	PUNCT
fnp-3806	282	10	although	although	SCONJ
fnp-3806	282	11	the	the	DET
fnp-3806	282	12	density	density	NOUN
fnp-3806	282	13	of	of	ADP
fnp-3806	282	14	gabaergic	gabaergic	ADJ
fnp-3806	282	15	neurons	neuron	NOUN
fnp-3806	282	16	decreases	decrease	NOUN
fnp-3806	282	17	and	and	CCONJ
fnp-3806	282	18	gaba	gaba	NOUN
fnp-3806	282	19	-	-	PUNCT
fnp-3806	282	20	uptake	uptake	ADJ
fnp-3806	282	21	is	be	AUX
fnp-3806	282	22	impaired	impair	VERB
fnp-3806	282	23	in	in	ADP
fnp-3806	282	24	sad	sad	ADJ
fnp-3806	282	25	(	(	PUNCT
fnp-3806	282	26	296	296	NUM
fnp-3806	282	27	-	-	SYM
fnp-3806	282	28	300	300	NUM
fnp-3806	282	29	)	)	PUNCT
fnp-3806	282	30	(	(	PUNCT
fnp-3806	282	31	see	see	VERB
fnp-3806	282	32	section	section	NOUN
fnp-3806	282	33	6	6	NUM
fnp-3806	282	34	for	for	ADP
fnp-3806	282	35	details	detail	NOUN
fnp-3806	282	36	)	)	PUNCT
fnp-3806	282	37	.	.	PUNCT
fnp-3806	283	1	somatostain	somatostain	NOUN
fnp-3806	283	2	,	,	PUNCT
fnp-3806	283	3	which	which	PRON
fnp-3806	283	4	is	be	AUX
fnp-3806	283	5	expressed	express	VERB
fnp-3806	283	6	in	in	ADP
fnp-3806	283	7	a	a	DET
fnp-3806	283	8	subpopulation	subpopulation	NOUN
fnp-3806	283	9	of	of	ADP
fnp-3806	283	10	inhibitory	inhibitory	ADJ
fnp-3806	283	11	neurons	neuron	NOUN
fnp-3806	283	12	,	,	PUNCT
fnp-3806	283	13	and	and	CCONJ
fnp-3806	283	14	somatostatin	somatostatin	NOUN
fnp-3806	283	15	receptors	receptor	NOUN
fnp-3806	283	16	are	be	AUX
fnp-3806	283	17	also	also	ADV
fnp-3806	283	18	reduced	reduce	VERB
fnp-3806	283	19	in	in	ADP
fnp-3806	283	20	sad	sad	ADJ
fnp-3806	283	21	(	(	PUNCT
fnp-3806	283	22	296	296	NUM
fnp-3806	283	23	,	,	PUNCT
fnp-3806	283	24	301	301	NUM
fnp-3806	283	25	,	,	PUNCT
fnp-3806	283	26	302	302	NUM
fnp-3806	283	27	)	)	PUNCT
fnp-3806	283	28	.	.	PUNCT
fnp-3806	284	1	calcium	calcium	NOUN
fnp-3806	284	2	-	-	PUNCT
fnp-3806	284	3	binding	bind	VERB
fnp-3806	284	4	proteins	protein	NOUN
fnp-3806	284	5	parvalbumin	parvalbumin	NOUN
fnp-3806	284	6	(	(	PUNCT
fnp-3806	284	7	pv	pv	NOUN
fnp-3806	284	8	)	)	PUNCT
fnp-3806	284	9	,	,	PUNCT
fnp-3806	284	10	calbindin	calbindin	VERB
fnp-3806	284	11	d28k	d28k	PROPN
fnp-3806	284	12	(	(	PUNCT
fnp-3806	284	13	cb	cb	PROPN
fnp-3806	284	14	)	)	PUNCT
fnp-3806	284	15	and	and	CCONJ
fnp-3806	284	16	caretinin	caretinin	ADJ
fnp-3806	284	17	(	(	PUNCT
fnp-3806	284	18	cr	cr	NOUN
fnp-3806	284	19	)	)	PUNCT
fnp-3806	284	20	are	be	AUX
fnp-3806	284	21	expressed	express	VERB
fnp-3806	284	22	in	in	ADP
fnp-3806	284	23	subpopulations	subpopulation	NOUN
fnp-3806	284	24	of	of	ADP
fnp-3806	284	25	gabaergic	gabaergic	ADJ
fnp-3806	284	26	neurons	neuron	NOUN
fnp-3806	284	27	(	(	PUNCT
fnp-3806	284	28	303	303	NUM
fnp-3806	284	29	-	-	SYM
fnp-3806	284	30	305	305	NUM
fnp-3806	284	31	)	)	PUNCT
fnp-3806	284	32	.	.	PUNCT
fnp-3806	285	1	pv	pv	VERB
fnp-3806	285	2	-	-	PUNCT
fnp-3806	285	3	positive	positive	ADJ
fnp-3806	285	4	neuron	neuron	NOUN
fnp-3806	285	5	numbers	number	NOUN
fnp-3806	285	6	in	in	ADP
fnp-3806	285	7	the	the	DET
fnp-3806	285	8	temporal	temporal	ADJ
fnp-3806	285	9	,	,	PUNCT
fnp-3806	285	10	visual	visual	ADJ
fnp-3806	285	11	,	,	PUNCT
fnp-3806	285	12	and	and	CCONJ
fnp-3806	285	13	prefrontal	prefrontal	ADJ
fnp-3806	285	14	cortex	cortex	NOUN
fnp-3806	285	15	are	be	AUX
fnp-3806	285	16	preserved	preserve	VERB
fnp-3806	285	17	in	in	ADP
fnp-3806	285	18	ad	ad	NOUN
fnp-3806	285	19	(	(	PUNCT
fnp-3806	285	20	306	306	NUM
fnp-3806	285	21	-	-	SYM
fnp-3806	285	22	309	309	NUM
fnp-3806	285	23	)	)	PUNCT
fnp-3806	285	24	,	,	PUNCT
fnp-3806	285	25	but	but	CCONJ
fnp-3806	285	26	pv	pv	X
fnp-3806	285	27	-	-	PUNCT
fnp-3806	285	28	immunoreactive	immunoreactive	ADJ
fnp-3806	285	29	neurons	neuron	NOUN
fnp-3806	285	30	are	be	AUX
fnp-3806	285	31	decreased	decrease	VERB
fnp-3806	285	32	in	in	ADP
fnp-3806	285	33	the	the	DET
fnp-3806	285	34	entorhinal	entorhinal	ADJ
fnp-3806	285	35	cortex	cortex	NOUN
fnp-3806	285	36	and	and	CCONJ
fnp-3806	285	37	hippocampus	hippocampus	NOUN
fnp-3806	285	38	in	in	ADP
fnp-3806	285	39	sad	sad	ADJ
fnp-3806	285	40	(	(	PUNCT
fnp-3806	285	41	310	310	NUM
fnp-3806	285	42	-	-	SYM
fnp-3806	285	43	316	316	NUM
fnp-3806	285	44	)	)	PUNCT
fnp-3806	285	45	.	.	PUNCT
fnp-3806	286	1	cb	cb	NOUN
fnp-3806	286	2	-	-	ADJ
fnp-3806	286	3	immunoreactive	immunoreactive	ADJ
fnp-3806	286	4	neurons	neuron	NOUN
fnp-3806	286	5	in	in	ADP
fnp-3806	286	6	the	the	DET
fnp-3806	286	7	hippocampus	hippocampus	NOUN
fnp-3806	286	8	,	,	PUNCT
fnp-3806	286	9	entorhinal	entorhinal	ADJ
fnp-3806	286	10	cortex	cortex	NOUN
fnp-3806	286	11	,	,	PUNCT
fnp-3806	286	12	and	and	CCONJ
fnp-3806	286	13	cortical	cortical	ADJ
fnp-3806	286	14	layers	layer	NOUN
fnp-3806	286	15	v	v	NOUN
fnp-3806	286	16	and	and	CCONJ
fnp-3806	286	17	vi	vi	PROPN
fnp-3806	286	18	are	be	AUX
fnp-3806	286	19	vulnerable	vulnerable	ADJ
fnp-3806	286	20	,	,	PUNCT
fnp-3806	286	21	whereas	whereas	SCONJ
fnp-3806	286	22	cb	cb	ADJ
fnp-3806	286	23	-	-	ADJ
fnp-3806	286	24	positive	positive	ADJ
fnp-3806	286	25	neurons	neuron	NOUN
fnp-3806	286	26	in	in	ADP
fnp-3806	286	27	the	the	DET
fnp-3806	286	28	occipital	occipital	ADJ
fnp-3806	286	29	cortex	cortex	NOUN
fnp-3806	286	30	and	and	CCONJ
fnp-3806	286	31	upper	upper	ADJ
fnp-3806	286	32	layers	layer	NOUN
fnp-3806	286	33	of	of	ADP
fnp-3806	286	34	the	the	DET
fnp-3806	286	35	frontal	frontal	ADJ
fnp-3806	286	36	cortex	cortex	NOUN
fnp-3806	286	37	are	be	AUX
fnp-3806	286	38	resistant	resistant	ADJ
fnp-3806	286	39	(	(	PUNCT
fnp-3806	286	40	309	309	NUM
fnp-3806	286	41	,	,	PUNCT
fnp-3806	286	42	314	314	NUM
fnp-3806	286	43	,	,	PUNCT
fnp-3806	286	44	314	314	NUM
fnp-3806	286	45	,	,	PUNCT
fnp-3806	286	46	317	317	NUM
fnp-3806	286	47	)	)	PUNCT
fnp-3806	286	48	.	.	PUNCT
fnp-3806	287	1	cr	cr	X
fnp-3806	287	2	-	-	PUNCT
fnp-3806	287	3	positive	positive	ADJ
fnp-3806	287	4	neurons	neuron	NOUN
fnp-3806	287	5	are	be	AUX
fnp-3806	287	6	not	not	PART
fnp-3806	287	7	affected	affect	VERB
fnp-3806	287	8	in	in	ADP
fnp-3806	287	9	the	the	DET
fnp-3806	287	10	prefrontal	prefrontal	ADJ
fnp-3806	287	11	,	,	PUNCT
fnp-3806	287	12	temporal	temporal	ADJ
fnp-3806	287	13	,	,	PUNCT
fnp-3806	287	14	and	and	CCONJ
fnp-3806	287	15	visual	visual	ADJ
fnp-3806	287	16	cortices	cortex	NOUN
fnp-3806	287	17	(	(	PUNCT
fnp-3806	287	18	309	309	NUM
fnp-3806	287	19	,	,	PUNCT
fnp-3806	287	20	319	319	NUM
fnp-3806	287	21	,	,	PUNCT
fnp-3806	287	22	320	320	NUM
fnp-3806	287	23	)	)	PUNCT
fnp-3806	287	24	,	,	PUNCT
fnp-3806	287	25	but	but	CCONJ
fnp-3806	287	26	their	their	PRON
fnp-3806	287	27	number	number	NOUN
fnp-3806	287	28	is	be	AUX
fnp-3806	287	29	reduced	reduce	VERB
fnp-3806	287	30	in	in	ADP
fnp-3806	287	31	the	the	DET
fnp-3806	287	32	hippocampus	hippocampus	NOUN
fnp-3806	287	33	and	and	CCONJ
fnp-3806	287	34	entorhinal	entorhinal	ADJ
fnp-3806	287	35	cortex	cortex	NOUN
fnp-3806	287	36	(	(	PUNCT
fnp-3806	287	37	314	314	NUM
fnp-3806	287	38	,	,	PUNCT
fnp-3806	287	39	321	321	NUM
fnp-3806	287	40	)	)	PUNCT
fnp-3806	287	41	.	.	PUNCT
fnp-3806	288	1	pv	pv	NOUN
fnp-3806	288	2	and	and	CCONJ
fnp-3806	288	3	somatostin	somatostin	ADJ
fnp-3806	288	4	,	,	PUNCT
fnp-3806	288	5	together	together	ADV
fnp-3806	288	6	with	with	ADP
fnp-3806	288	7	neuropeptide	neuropeptide	NOUN
fnp-3806	288	8	y	y	NOUN
fnp-3806	288	9	,	,	PUNCT
fnp-3806	288	10	cholecystokinin	cholecystokinin	NOUN
fnp-3806	288	11	and	and	CCONJ
fnp-3806	288	12	substance	substance	NOUN
fnp-3806	288	13	p	p	NOUN
fnp-3806	288	14	,	,	PUNCT
fnp-3806	288	15	are	be	AUX
fnp-3806	288	16	found	find	VERB
fnp-3806	288	17	in	in	ADP
fnp-3806	288	18	dystrophic	dystrophic	ADJ
fnp-3806	288	19	neurites	neurite	NOUN
fnp-3806	288	20	of	of	ADP
fnp-3806	288	21	sps	sps	PROPN
fnp-3806	288	22	,	,	PUNCT
fnp-3806	288	23	thus	thus	ADV
fnp-3806	288	24	evidencing	evidence	VERB
fnp-3806	288	25	the	the	DET
fnp-3806	288	26	involvement	involvement	NOUN
fnp-3806	288	27	of	of	ADP
fnp-3806	288	28	inhibitory	inhibitory	ADJ
fnp-3806	288	29	and	and	CCONJ
fnp-3806	288	30	peptidergic	peptidergic	ADJ
fnp-3806	288	31	neurons	neuron	NOUN
fnp-3806	288	32	in	in	ADP
fnp-3806	288	33	sps	sps	PROPN
fnp-3806	288	34	(	(	PUNCT
fnp-3806	288	35	130	130	NUM
fnp-3806	288	36	,	,	PUNCT
fnp-3806	288	37	144	144	NUM
fnp-3806	288	38	)	)	PUNCT
fnp-3806	288	39	.	.	PUNCT
fnp-3806	289	1	neuron	neuron	PROPN
fnp-3806	289	2	loss	loss	NOUN
fnp-3806	289	3	is	be	AUX
fnp-3806	289	4	negligible	negligible	ADJ
fnp-3806	289	5	in	in	ADP
fnp-3806	289	6	cognitively	cognitively	ADV
fnp-3806	289	7	normal	normal	ADJ
fnp-3806	289	8	subjects	subject	NOUN
fnp-3806	289	9	,	,	PUNCT
fnp-3806	289	10	but	but	CCONJ
fnp-3806	289	11	the	the	DET
fnp-3806	289	12	number	number	NOUN
fnp-3806	289	13	of	of	ADP
fnp-3806	289	14	neurons	neuron	NOUN
fnp-3806	289	15	decreases	decrease	VERB
fnp-3806	289	16	in	in	ADP
fnp-3806	289	17	the	the	DET
fnp-3806	289	18	hippocampus	hippocampus	NOUN
fnp-3806	289	19	and	and	CCONJ
fnp-3806	289	20	entorhinal	entorhinal	ADJ
fnp-3806	289	21	cortex	cortex	NOUN
fnp-3806	289	22	with	with	ADP
fnp-3806	289	23	nft	nft	PROPN
fnp-3806	289	24	progression	progression	NOUN
fnp-3806	289	25	(	(	PUNCT
fnp-3806	289	26	322	322	NUM
fnp-3806	289	27	-	-	SYM
fnp-3806	289	28	324	324	NUM
fnp-3806	289	29	)	)	PUNCT
fnp-3806	289	30	.	.	PUNCT
fnp-3806	290	1	the	the	DET
fnp-3806	290	2	rate	rate	NOUN
fnp-3806	290	3	of	of	ADP
fnp-3806	290	4	this	this	DET
fnp-3806	290	5	process	process	NOUN
fnp-3806	290	6	is	be	AUX
fnp-3806	290	7	extremely	extremely	ADV
fnp-3806	290	8	variable	variable	ADJ
fnp-3806	290	9	among	among	ADP
fnp-3806	290	10	individuals	individual	NOUN
fnp-3806	290	11	.	.	PUNCT
fnp-3806	291	1	a	a	DET
fnp-3806	291	2	major	major	ADJ
fnp-3806	291	3	achievement	achievement	NOUN
fnp-3806	291	4	in	in	ADP
fnp-3806	291	5	improving	improve	VERB
fnp-3806	291	6	our	our	PRON
fnp-3806	291	7	understanding	understanding	NOUN
fnp-3806	291	8	of	of	ADP
fnp-3806	291	9	the	the	DET
fnp-3806	291	10	progression	progression	NOUN
fnp-3806	291	11	of	of	ADP
fnp-3806	291	12	sad	sad	ADJ
fnp-3806	291	13	pathology	pathology	NOUN
fnp-3806	291	14	was	be	AUX
fnp-3806	291	15	the	the	DET
fnp-3806	291	16	staging	staging	NOUN
fnp-3806	291	17	of	of	ADP
fnp-3806	291	18	nfts	nft	NOUN
fnp-3806	291	19	and	and	CCONJ
fnp-3806	291	20	sps	sps	NOUN
fnp-3806	291	21	in	in	ADP
fnp-3806	291	22	the	the	DET
fnp-3806	291	23	post	post	ADJ
fnp-3806	291	24	-	-	ADJ
fnp-3806	291	25	mortem	mortem	ADJ
fnp-3806	291	26	brain	brain	NOUN
fnp-3806	291	27	of	of	ADP
fnp-3806	291	28	large	large	ADJ
fnp-3806	291	29	cohorts	cohort	NOUN
fnp-3806	291	30	of	of	ADP
fnp-3806	291	31	non	non	ADJ
fnp-3806	291	32	-	-	ADJ
fnp-3806	291	33	demented	demented	ADJ
fnp-3806	291	34	and	and	CCONJ
fnp-3806	291	35	demented	demented	ADJ
fnp-3806	291	36	individuals	individual	NOUN
fnp-3806	291	37	covering	cover	VERB
fnp-3806	291	38	a	a	DET
fnp-3806	291	39	natural	natural	ADJ
fnp-3806	291	40	human	human	ADJ
fnp-3806	291	41	population	population	NOUN
fnp-3806	291	42	.	.	PUNCT
fnp-3806	292	1	in	in	ADP
fnp-3806	292	2	the	the	DET
fnp-3806	292	3	telencephalon	telencephalon	NOUN
fnp-3806	292	4	,	,	PUNCT
fnp-3806	292	5	the	the	DET
fnp-3806	292	6	first	first	ADJ
fnp-3806	292	7	nfts	nft	NOUN
fnp-3806	292	8	appear	appear	VERB
fnp-3806	292	9	in	in	ADP
fnp-3806	292	10	the	the	DET
fnp-3806	292	11	entorhinal	entorhinal	ADJ
fnp-3806	292	12	and	and	CCONJ
fnp-3806	292	13	transentorhinal	transentorhinal	ADJ
fnp-3806	292	14	cortex	cortex	NOUN
fnp-3806	292	15	(	(	PUNCT
fnp-3806	292	16	stages	stage	NOUN
fnp-3806	292	17	i	i	PROPN
fnp-3806	292	18	-	-	PUNCT
fnp-3806	292	19	ii	ii	NOUN
fnp-3806	292	20	)	)	PUNCT
fnp-3806	292	21	,	,	PUNCT
fnp-3806	292	22	followed	follow	VERB
fnp-3806	292	23	by	by	ADP
fnp-3806	292	24	the	the	DET
fnp-3806	292	25	hippocampus	hippocampus	NOUN
fnp-3806	292	26	,	,	PUNCT
fnp-3806	292	27	temporal	temporal	ADJ
fnp-3806	292	28	cortex	cortex	NOUN
fnp-3806	292	29	,	,	PUNCT
fnp-3806	292	30	and	and	CCONJ
fnp-3806	292	31	other	other	ADJ
fnp-3806	292	32	nuclei	nucleus	NOUN
fnp-3806	292	33	of	of	ADP
fnp-3806	292	34	limbic	limbic	ADJ
fnp-3806	292	35	system	system	NOUN
fnp-3806	292	36	(	(	PUNCT
fnp-3806	292	37	stages	stage	NOUN
fnp-3806	292	38	iii	iii	NOUN
fnp-3806	292	39	-	-	PUNCT
fnp-3806	292	40	iv	iv	NUM
fnp-3806	292	41	)	)	PUNCT
fnp-3806	292	42	,	,	PUNCT
fnp-3806	292	43	and	and	CCONJ
fnp-3806	292	44	then	then	ADV
fnp-3806	292	45	continue	continue	VERB
fnp-3806	292	46	on	on	ADP
fnp-3806	292	47	to	to	ADP
fnp-3806	292	48	most	most	ADJ
fnp-3806	292	49	areas	area	NOUN
fnp-3806	292	50	of	of	ADP
fnp-3806	292	51	the	the	DET
fnp-3806	292	52	neocortex	neocortex	NOUN
fnp-3806	292	53	(	(	PUNCT
fnp-3806	292	54	stages	stage	NOUN
fnp-3806	292	55	v	v	NOUN
fnp-3806	292	56	-	-	PUNCT
fnp-3806	292	57	vi	vi	NOUN
fnp-3806	292	58	)	)	PUNCT
fnp-3806	292	59	.	.	PUNCT
fnp-3806	293	1	the	the	DET
fnp-3806	293	2	spreading	spreading	NOUN
fnp-3806	293	3	of	of	ADP
fnp-3806	293	4	nfts	nft	NOUN
fnp-3806	293	5	is	be	AUX
fnp-3806	293	6	accompanied	accompany	VERB
fnp-3806	293	7	by	by	ADP
fnp-3806	293	8	a	a	DET
fnp-3806	293	9	dramatic	dramatic	ADJ
fnp-3806	293	10	increase	increase	NOUN
fnp-3806	293	11	in	in	ADP
fnp-3806	293	12	the	the	DET
fnp-3806	293	13	number	number	NOUN
fnp-3806	293	14	of	of	ADP
fnp-3806	293	15	neurons	neuron	NOUN
fnp-3806	293	16	with	with	ADP
fnp-3806	293	17	nft	nft	PROPN
fnp-3806	293	18	pathology	pathology	PROPN
fnp-3806	293	19	across	across	ADP
fnp-3806	293	20	stage	stage	NOUN
fnp-3806	293	21	progression	progression	NOUN
fnp-3806	293	22	(	(	PUNCT
fnp-3806	293	23	41	41	NUM
fnp-3806	293	24	,	,	PUNCT
fnp-3806	293	25	325	325	NUM
fnp-3806	293	26	-	-	SYM
fnp-3806	293	27	327	327	NUM
fnp-3806	293	28	)	)	PUNCT
fnp-3806	293	29	.	.	PUNCT
fnp-3806	294	1	about	about	ADV
fnp-3806	294	2	85	85	NUM
fnp-3806	294	3	%	%	NOUN
fnp-3806	294	4	of	of	ADP
fnp-3806	294	5	individuals	individual	NOUN
fnp-3806	294	6	aged	age	VERB
fnp-3806	294	7	65	65	NUM
fnp-3806	294	8	have	have	VERB
fnp-3806	294	9	nft	nft	PROPN
fnp-3806	294	10	pathology	pathology	PROPN
fnp-3806	294	11	,	,	PUNCT
fnp-3806	294	12	at	at	ADP
fnp-3806	294	13	least	least	ADJ
fnp-3806	294	14	restricted	restrict	VERB
fnp-3806	294	15	to	to	ADP
fnp-3806	294	16	stages	stage	NOUN
fnp-3806	294	17	i	i	PROPN
fnp-3806	294	18	-	-	PUNCT
fnp-3806	294	19	iii	iii	PROPN
fnp-3806	294	20	(	(	PUNCT
fnp-3806	294	21	41	41	NUM
fnp-3806	294	22	,	,	PUNCT
fnp-3806	294	23	325	325	NUM
fnp-3806	294	24	,	,	PUNCT
fnp-3806	294	25	328	328	NUM
fnp-3806	294	26	,	,	PUNCT
fnp-3806	294	27	329	329	NUM
fnp-3806	294	28	)	)	PUNCT
fnp-3806	294	29	.	.	PUNCT
fnp-3806	295	1	all	all	PRON
fnp-3806	295	2	of	of	ADP
fnp-3806	295	3	them	they	PRON
fnp-3806	295	4	,	,	PUNCT
fnp-3806	295	5	excluding	exclude	VERB
fnp-3806	295	6	those	those	PRON
fnp-3806	295	7	having	have	VERB
fnp-3806	295	8	concomitant	concomitant	ADJ
fnp-3806	295	9	pathologies	pathology	NOUN
fnp-3806	295	10	,	,	PUNCT
fnp-3806	295	11	are	be	AUX
fnp-3806	295	12	considered	consider	VERB
fnp-3806	295	13	“	"	PUNCT
fnp-3806	295	14	cognitively	cognitively	ADV
fnp-3806	295	15	normal	normal	ADJ
fnp-3806	295	16	for	for	ADP
fnp-3806	295	17	age	age	NOUN
fnp-3806	295	18	”	"	PUNCT
fnp-3806	295	19	(	(	PUNCT
fnp-3806	295	20	330	330	NUM
fnp-3806	295	21	)	)	PUNCT
fnp-3806	295	22	.	.	PUNCT
fnp-3806	296	1	some	some	DET
fnp-3806	296	2	individuals	individual	NOUN
fnp-3806	296	3	at	at	ADP
fnp-3806	296	4	stage	stage	NOUN
fnp-3806	296	5	iv	iv	NUM
fnp-3806	296	6	-	-	PUNCT
fnp-3806	296	7	v	v	NOUN
fnp-3806	296	8	suffer	suffer	VERB
fnp-3806	296	9	from	from	ADP
fnp-3806	296	10	moderate	moderate	ADJ
fnp-3806	296	11	cognitive	cognitive	ADJ
fnp-3806	296	12	impairment	impairment	NOUN
fnp-3806	296	13	;	;	PUNCT
fnp-3806	296	14	only	only	ADV
fnp-3806	296	15	about	about	ADV
fnp-3806	296	16	5	5	NUM
fnp-3806	296	17	%	%	NOUN
fnp-3806	296	18	have	have	VERB
fnp-3806	296	19	dementia	dementia	NOUN
fnp-3806	296	20	.	.	PUNCT
fnp-3806	297	1	however	however	ADV
fnp-3806	297	2	,	,	PUNCT
fnp-3806	297	3	dementia	dementia	NOUN
fnp-3806	297	4	of	of	ADP
fnp-3806	297	5	ad	ad	NOUN
fnp-3806	297	6	type	type	NOUN
fnp-3806	297	7	accounts	account	VERB
fnp-3806	297	8	for	for	ADP
fnp-3806	297	9	about	about	ADP
fnp-3806	297	10	25%-30	25%-30	NUM
fnp-3806	297	11	%	%	NOUN
fnp-3806	297	12	of	of	ADP
fnp-3806	297	13	the	the	DET
fnp-3806	297	14	population	population	NOUN
fnp-3806	297	15	at	at	ADP
fnp-3806	297	16	the	the	DET
fnp-3806	297	17	age	age	NOUN
fnp-3806	297	18	of	of	ADP
fnp-3806	297	19	85	85	NUM
fnp-3806	297	20	years	year	NOUN
fnp-3806	297	21	,	,	PUNCT
fnp-3806	297	22	all	all	PRON
fnp-3806	297	23	of	of	ADP
fnp-3806	297	24	them	they	PRON
fnp-3806	297	25	categorized	categorize	VERB
fnp-3806	297	26	as	as	ADP
fnp-3806	297	27	nft	nft	PROPN
fnp-3806	297	28	stages	stage	NOUN
fnp-3806	297	29	v	v	PROPN
fnp-3806	297	30	-	-	PUNCT
fnp-3806	297	31	vi	vi	NOUN
fnp-3806	297	32	(	(	PUNCT
fnp-3806	297	33	331	331	NUM
fnp-3806	297	34	)	)	PUNCT
fnp-3806	297	35	.	.	PUNCT
fnp-3806	298	1	regionaland	regionaland	NOUN
fnp-3806	298	2	stage	stage	NOUN
fnp-3806	298	3	-	-	PUNCT
fnp-3806	298	4	dependent	dependent	ADJ
fnp-3806	298	5	neuropathological	neuropathological	ADJ
fnp-3806	298	6	alterations	alteration	NOUN
fnp-3806	298	7	in	in	ADP
fnp-3806	298	8	sad	sad	ADJ
fnp-3806	298	9	are	be	AUX
fnp-3806	298	10	accompanied	accompany	VERB
fnp-3806	298	11	by	by	ADP
fnp-3806	298	12	specified	specify	VERB
fnp-3806	298	13	patterns	pattern	NOUN
fnp-3806	298	14	of	of	ADP
fnp-3806	298	15	altered	altered	ADJ
fnp-3806	298	16	gene	gene	NOUN
fnp-3806	298	17	expression	expression	NOUN
fnp-3806	298	18	,	,	PUNCT
fnp-3806	298	19	that	that	PRON
fnp-3806	298	20	extend	extend	VERB
fnp-3806	298	21	beyond	beyond	ADP
fnp-3806	298	22	the	the	DET
fnp-3806	298	23	genes	gene	NOUN
fnp-3806	298	24	implicated	implicate	VERB
fnp-3806	298	25	in	in	ADP
fnp-3806	298	26	tau	tau	PROPN
fnp-3806	298	27	and	and	CCONJ
fnp-3806	298	28	β	β	NOUN
fnp-3806	298	29	-	-	ADJ
fnp-3806	298	30	amyloid	amyloid	ADJ
fnp-3806	298	31	pathology	pathology	NOUN
fnp-3806	298	32	(	(	PUNCT
fnp-3806	298	33	332	332	NUM
fnp-3806	298	34	)	)	PUNCT
fnp-3806	298	35	.	.	PUNCT
fnp-3806	299	1	the	the	DET
fnp-3806	299	2	braak	braak	NOUN
fnp-3806	299	3	staging	stage	VERB
fnp-3806	299	4	scheme	scheme	NOUN
fnp-3806	299	5	does	do	AUX
fnp-3806	299	6	not	not	PART
fnp-3806	299	7	rule	rule	VERB
fnp-3806	299	8	out	out	ADP
fnp-3806	299	9	the	the	DET
fnp-3806	299	10	occurrence	occurrence	NOUN
fnp-3806	299	11	of	of	ADP
fnp-3806	299	12	exceptions	exception	NOUN
fnp-3806	299	13	that	that	PRON
fnp-3806	299	14	do	do	AUX
fnp-3806	299	15	not	not	PART
fnp-3806	299	16	fulfil	fulfil	VERB
fnp-3806	299	17	the	the	DET
fnp-3806	299	18	strict	strict	ADJ
fnp-3806	299	19	neuropathological	neuropathological	ADJ
fnp-3806	299	20	criteria	criterion	NOUN
fnp-3806	299	21	.	.	PUNCT
fnp-3806	300	1	these	these	DET
fnp-3806	300	2	untypical	untypical	ADJ
fnp-3806	300	3	cases	case	NOUN
fnp-3806	300	4	are	be	AUX
fnp-3806	300	5	considered	consider	VERB
fnp-3806	300	6	ad	ad	NOUN
fnp-3806	300	7	subtypes	subtype	NOUN
fnp-3806	300	8	:	:	PUNCT
fnp-3806	300	9	hippocampal	hippocampal	ADJ
fnp-3806	300	10	sparing	sparing	NOUN
fnp-3806	300	11	,	,	PUNCT
fnp-3806	300	12	limbic	limbic	NOUN
fnp-3806	300	13	-	-	PUNCT
fnp-3806	300	14	predominant	predominant	ADJ
fnp-3806	300	15	,	,	PUNCT
fnp-3806	300	16	and	and	CCONJ
fnp-3806	300	17	minimal	minimal	ADJ
fnp-3806	300	18	atrophy	atrophy	NOUN
fnp-3806	300	19	sad	sad	ADJ
fnp-3806	300	20	subtypes	subtype	NOUN
fnp-3806	300	21	might	might	AUX
fnp-3806	300	22	account	account	VERB
fnp-3806	300	23	for	for	ADP
fnp-3806	300	24	about	about	ADV
fnp-3806	300	25	25	25	NUM
fnp-3806	300	26	%	%	NOUN
fnp-3806	300	27	of	of	ADP
fnp-3806	300	28	cases	case	NOUN
fnp-3806	300	29	(	(	PUNCT
fnp-3806	300	30	333	333	NUM
fnp-3806	300	31	)	)	PUNCT
fnp-3806	300	32	.	.	PUNCT
fnp-3806	301	1	in	in	ADP
fnp-3806	301	2	addition	addition	NOUN
fnp-3806	301	3	,	,	PUNCT
fnp-3806	301	4	several	several	ADJ
fnp-3806	301	5	clinical	clinical	ADJ
fnp-3806	301	6	sad	sad	ADJ
fnp-3806	301	7	variants	variant	NOUN
fnp-3806	301	8	including	include	VERB
fnp-3806	301	9	non	non	ADJ
fnp-3806	301	10	-	-	ADJ
fnp-3806	301	11	amnestic	amnestic	ADJ
fnp-3806	301	12	,	,	PUNCT
fnp-3806	301	13	corticobasal	corticobasal	NOUN
fnp-3806	301	14	syndromal	syndromal	NOUN
fnp-3806	301	15	,	,	PUNCT
fnp-3806	301	16	primary	primary	ADJ
fnp-3806	301	17	progressive	progressive	ADJ
fnp-3806	301	18	aphasia	aphasia	NOUN
fnp-3806	301	19	,	,	PUNCT
fnp-3806	301	20	posterior	posterior	ADJ
fnp-3806	301	21	cortical	cortical	ADJ
fnp-3806	301	22	atrophy	atrophy	NOUN
fnp-3806	301	23	,	,	PUNCT
fnp-3806	301	24	behavioral	behavioral	ADJ
fnp-3806	301	25	/	/	SYM
fnp-3806	301	26	dysexecutive	dysexecutive	ADJ
fnp-3806	301	27	,	,	PUNCT
fnp-3806	301	28	and	and	CCONJ
fnp-3806	301	29	mild	mild	ADJ
fnp-3806	301	30	dementia	dementia	NOUN
fnp-3806	301	31	variants	variant	NOUN
fnp-3806	301	32	have	have	AUX
fnp-3806	301	33	been	be	AUX
fnp-3806	301	34	categorized	categorize	VERB
fnp-3806	301	35	(	(	PUNCT
fnp-3806	301	36	334	334	NUM
fnp-3806	301	37	)	)	PUNCT
fnp-3806	301	38	.	.	PUNCT
fnp-3806	302	1	the	the	DET
fnp-3806	302	2	olfactory	olfactory	NOUN
fnp-3806	302	3	bulb	bulb	NOUN
fnp-3806	302	4	and	and	CCONJ
fnp-3806	302	5	tract	tract	NOUN
fnp-3806	302	6	,	,	PUNCT
fnp-3806	302	7	and	and	CCONJ
fnp-3806	302	8	several	several	ADJ
fnp-3806	302	9	nuclei	nucleus	NOUN
fnp-3806	302	10	of	of	ADP
fnp-3806	302	11	the	the	DET
fnp-3806	302	12	brain	brain	NOUN
fnp-3806	302	13	stem	stem	NOUN
fnp-3806	302	14	including	include	VERB
fnp-3806	302	15	the	the	DET
fnp-3806	302	16	raphe	raphe	NOUN
fnp-3806	302	17	nuclei	nucleus	NOUN
fnp-3806	302	18	and	and	CCONJ
fnp-3806	302	19	the	the	DET
fnp-3806	302	20	locus	locus	NOUN
fnp-3806	302	21	coeruleus	coeruleus	NOUN
fnp-3806	302	22	,	,	PUNCT
fnp-3806	302	23	are	be	AUX
fnp-3806	302	24	affected	affect	VERB
fnp-3806	302	25	by	by	ADP
fnp-3806	302	26	nft	nft	PROPN
fnp-3806	302	27	formation	formation	NOUN
fnp-3806	302	28	at	at	ADP
fnp-3806	302	29	the	the	DET
fnp-3806	302	30	first	first	ADJ
fnp-3806	302	31	stages	stage	NOUN
fnp-3806	302	32	of	of	ADP
fnp-3806	302	33	nft	nft	PROPN
fnp-3806	302	34	pathology	pathology	PROPN
fnp-3806	302	35	.	.	PUNCT
fnp-3806	303	1	the	the	DET
fnp-3806	303	2	involvement	involvement	NOUN
fnp-3806	303	3	of	of	ADP
fnp-3806	303	4	the	the	DET
fnp-3806	303	5	olfactory	olfactory	NOUN
fnp-3806	303	6	bulb	bulb	NOUN
fnp-3806	303	7	and	and	CCONJ
fnp-3806	303	8	tracts	tract	NOUN
fnp-3806	303	9	may	may	AUX
fnp-3806	303	10	contribute	contribute	VERB
fnp-3806	303	11	to	to	ADP
fnp-3806	303	12	the	the	DET
fnp-3806	303	13	altered	altered	ADJ
fnp-3806	303	14	olfaction	olfaction	NOUN
fnp-3806	303	15	arising	arise	VERB
fnp-3806	303	16	in	in	ADP
fnp-3806	303	17	sad	sad	ADJ
fnp-3806	303	18	.	.	PUNCT
fnp-3806	304	1	damage	damage	NOUN
fnp-3806	304	2	to	to	ADP
fnp-3806	304	3	selected	select	VERB
fnp-3806	304	4	nuclei	nucleus	NOUN
fnp-3806	304	5	of	of	ADP
fnp-3806	304	6	the	the	DET
fnp-3806	304	7	brainstem	brainstem	NOUN
fnp-3806	304	8	,	,	PUNCT
fnp-3806	304	9	which	which	PRON
fnp-3806	304	10	are	be	AUX
fnp-3806	304	11	the	the	DET
fnp-3806	304	12	origin	origin	NOUN
fnp-3806	304	13	of	of	ADP
fnp-3806	304	14	major	major	ADJ
fnp-3806	304	15	serotoninergic	serotoninergic	ADJ
fnp-3806	304	16	and	and	CCONJ
fnp-3806	304	17	noradrenergic	noradrenergic	ADJ
fnp-3806	304	18	innervation	innervation	NOUN
fnp-3806	304	19	of	of	ADP
fnp-3806	304	20	the	the	DET
fnp-3806	304	21	entire	entire	ADJ
fnp-3806	304	22	brain	brain	NOUN
fnp-3806	304	23	,	,	PUNCT
fnp-3806	304	24	underlies	underlie	VERB
fnp-3806	304	25	a	a	DET
fnp-3806	304	26	large	large	ADJ
fnp-3806	304	27	series	series	NOUN
fnp-3806	304	28	of	of	ADP
fnp-3806	304	29	clinical	clinical	ADJ
fnp-3806	304	30	symptoms	symptom	NOUN
fnp-3806	304	31	including	include	VERB
fnp-3806	304	32	impaired	impaired	ADJ
fnp-3806	304	33	arousal	arousal	NOUN
fnp-3806	304	34	,	,	PUNCT
fnp-3806	304	35	loss	loss	NOUN
fnp-3806	304	36	of	of	ADP
fnp-3806	304	37	attention	attention	NOUN
fnp-3806	304	38	and	and	CCONJ
fnp-3806	304	39	memory	memory	NOUN
fnp-3806	304	40	,	,	PUNCT
fnp-3806	304	41	impaired	impaired	ADJ
fnp-3806	304	42	decision	decision	NOUN
fnp-3806	304	43	making	making	NOUN
fnp-3806	304	44	,	,	PUNCT
fnp-3806	304	45	apathy	apathy	NOUN
fnp-3806	304	46	,	,	PUNCT
fnp-3806	304	47	depression	depression	NOUN
fnp-3806	304	48	,	,	PUNCT
fnp-3806	304	49	anxiety	anxiety	NOUN
fnp-3806	304	50	,	,	PUNCT
fnp-3806	304	51	and	and	CCONJ
fnp-3806	304	52	altered	alter	VERB
fnp-3806	304	53	reward	reward	NOUN
fnp-3806	304	54	processing	processing	NOUN
fnp-3806	304	55	,	,	PUNCT
fnp-3806	304	56	among	among	ADP
fnp-3806	304	57	others	other	NOUN
fnp-3806	304	58	(	(	PUNCT
fnp-3806	304	59	335	335	NUM
fnp-3806	304	60	-	-	SYM
fnp-3806	304	61	340	340	NUM
fnp-3806	304	62	)	)	PUNCT
fnp-3806	304	63	.	.	PUNCT
fnp-3806	305	1	considered	consider	VERB
fnp-3806	305	2	together	together	ADV
fnp-3806	305	3	,	,	PUNCT
fnp-3806	305	4	nft	nft	PROPN
fnp-3806	305	5	generation	generation	NOUN
fnp-3806	305	6	and	and	CCONJ
fnp-3806	305	7	neuron	neuron	PROPN
fnp-3806	305	8	loss	loss	NOUN
fnp-3806	305	9	largely	largely	ADV
fnp-3806	305	10	depend	depend	VERB
fnp-3806	305	11	on	on	ADP
fnp-3806	305	12	the	the	DET
fnp-3806	305	13	specific	specific	ADJ
fnp-3806	305	14	cell	cell	NOUN
fnp-3806	305	15	and	and	CCONJ
fnp-3806	305	16	regional	regional	ADJ
fnp-3806	305	17	vulnerability	vulnerability	NOUN
fnp-3806	305	18	of	of	ADP
fnp-3806	305	19	specific	specific	ADJ
fnp-3806	305	20	neuronal	neuronal	ADJ
fnp-3806	305	21	populations	population	NOUN
fnp-3806	305	22	.	.	PUNCT
fnp-3806	306	1	moreover	moreover	ADV
fnp-3806	306	2	,	,	PUNCT
fnp-3806	306	3	the	the	DET
fnp-3806	306	4	simultaneous	simultaneous	ADJ
fnp-3806	306	5	presence	presence	NOUN
fnp-3806	306	6	of	of	ADP
fnp-3806	306	7	nft	nft	PROPN
fnp-3806	306	8	lesions	lesion	NOUN
fnp-3806	306	9	in	in	ADP
fnp-3806	306	10	separate	separate	ADJ
fnp-3806	306	11	brain	brain	NOUN
fnp-3806	306	12	regions	region	NOUN
fnp-3806	306	13	indicates	indicate	VERB
fnp-3806	306	14	that	that	SCONJ
fnp-3806	306	15	there	there	PRON
fnp-3806	306	16	is	be	VERB
fnp-3806	306	17	no	no	DET
fnp-3806	306	18	single	single	ADJ
fnp-3806	306	19	origin	origin	NOUN
fnp-3806	306	20	of	of	ADP
fnp-3806	306	21	nft	nft	PROPN
fnp-3806	306	22	pathology	pathology	PROPN
fnp-3806	306	23	that	that	PRON
fnp-3806	306	24	spreads	spread	VERB
fnp-3806	306	25	through	through	ADP
fnp-3806	306	26	the	the	DET
fnp-3806	306	27	brain	brain	NOUN
fnp-3806	306	28	,	,	PUNCT
fnp-3806	306	29	but	but	CCONJ
fnp-3806	306	30	rather	rather	ADV
fnp-3806	306	31	various	various	ADJ
fnp-3806	306	32	and	and	CCONJ
fnp-3806	306	33	cumulative	cumulative	ADJ
fnp-3806	306	34	original	original	ADJ
fnp-3806	306	35	sources	source	NOUN
fnp-3806	306	36	of	of	ADP
fnp-3806	306	37	tau	tau	PROPN
fnp-3806	306	38	pathology	pathology	NOUN
fnp-3806	306	39	in	in	ADP
fnp-3806	306	40	the	the	DET
fnp-3806	306	41	aging	age	VERB
fnp-3806	306	42	brain	brain	NOUN
fnp-3806	306	43	.	.	PUNCT
fnp-3806	307	1	additionally	additionally	ADV
fnp-3806	307	2	,	,	PUNCT
fnp-3806	307	3	the	the	DET
fnp-3806	307	4	rates	rate	NOUN
fnp-3806	307	5	of	of	ADP
fnp-3806	307	6	nft	nft	PROPN
fnp-3806	307	7	progression	progression	NOUN
fnp-3806	307	8	,	,	PUNCT
fnp-3806	307	9	although	although	SCONJ
fnp-3806	307	10	variable	variable	ADJ
fnp-3806	307	11	from	from	ADP
fnp-3806	307	12	one	one	NUM
fnp-3806	307	13	individual	individual	NOUN
fnp-3806	307	14	to	to	ADP
fnp-3806	307	15	another	another	PRON
fnp-3806	307	16	,	,	PUNCT
fnp-3806	307	17	appear	appear	VERB
fnp-3806	307	18	slowly	slowly	ADV
fnp-3806	307	19	at	at	ADP
fnp-3806	307	20	early	early	ADJ
fnp-3806	307	21	nft	nft	PROPN
fnp-3806	307	22	stages	stage	NOUN
fnp-3806	307	23	and	and	CCONJ
fnp-3806	307	24	progress	progress	VERB
fnp-3806	307	25	rapidly	rapidly	ADV
fnp-3806	307	26	at	at	ADP
fnp-3806	307	27	advanced	advanced	ADJ
fnp-3806	307	28	stages	stage	NOUN
fnp-3806	307	29	of	of	ADP
fnp-3806	307	30	the	the	DET
fnp-3806	307	31	disease	disease	NOUN
fnp-3806	307	32	(	(	PUNCT
fnp-3806	307	33	41	41	NUM
fnp-3806	307	34	)	)	PUNCT
fnp-3806	307	35	.	.	PUNCT
fnp-3806	308	1	the	the	DET
fnp-3806	308	2	distribution	distribution	NOUN
fnp-3806	308	3	of	of	ADP
fnp-3806	308	4	sps	sps	PROPN
fnp-3806	308	5	differs	differ	VERB
fnp-3806	308	6	from	from	ADP
fnp-3806	308	7	nfts	nft	NOUN
fnp-3806	308	8	in	in	ADP
fnp-3806	308	9	the	the	DET
fnp-3806	308	10	cerebral	cerebral	ADJ
fnp-3806	308	11	cortex	cortex	NOUN
fnp-3806	308	12	in	in	ADP
fnp-3806	308	13	patients	patient	NOUN
fnp-3806	308	14	with	with	ADP
fnp-3806	308	15	sad	sad	ADJ
fnp-3806	308	16	(	(	PUNCT
fnp-3806	308	17	341	341	NUM
fnp-3806	308	18	)	)	PUNCT
fnp-3806	308	19	.	.	PUNCT
fnp-3806	309	1	assessing	assess	VERB
fnp-3806	309	2	the	the	DET
fnp-3806	309	3	same	same	ADJ
fnp-3806	309	4	series	series	NOUN
fnp-3806	309	5	of	of	ADP
fnp-3806	309	6	cases	case	NOUN
fnp-3806	309	7	for	for	ADP
fnp-3806	309	8	the	the	DET
fnp-3806	309	9	study	study	NOUN
fnp-3806	309	10	of	of	ADP
fnp-3806	309	11	nft	nft	PROPN
fnp-3806	309	12	progression	progression	NOUN
fnp-3806	309	13	evidenced	evidence	VERB
fnp-3806	309	14	that	that	SCONJ
fnp-3806	309	15	the	the	DET
fnp-3806	309	16	localization	localization	NOUN
fnp-3806	309	17	and	and	CCONJ
fnp-3806	309	18	distribution	distribution	NOUN
fnp-3806	309	19	of	of	ADP
fnp-3806	309	20	sps	sps	NOUN
fnp-3806	309	21	largely	largely	ADV
fnp-3806	309	22	differ	differ	VERB
fnp-3806	309	23	from	from	ADP
fnp-3806	309	24	nft	nft	PROPN
fnp-3806	309	25	staging	staging	NOUN
fnp-3806	309	26	.	.	PUNCT
fnp-3806	310	1	the	the	DET
fnp-3806	310	2	majority	majority	NOUN
fnp-3806	310	3	of	of	ADP
fnp-3806	310	4	individuals	individual	NOUN
fnp-3806	310	5	at	at	ADP
fnp-3806	310	6	nft	nft	PROPN
fnp-3806	310	7	stages	stage	NOUN
fnp-3806	310	8	i	i	PROPN
fnp-3806	310	9	-	-	PUNCT
fnp-3806	310	10	ii	ii	PROPN
fnp-3806	310	11	and	and	CCONJ
fnp-3806	310	12	almost	almost	ADV
fnp-3806	310	13	half	half	NOUN
fnp-3806	310	14	of	of	ADP
fnp-3806	310	15	those	those	PRON
fnp-3806	310	16	at	at	ADP
fnp-3806	310	17	stage	stage	NOUN
fnp-3806	310	18	iii	iii	NUM
fnp-3806	310	19	do	do	AUX
fnp-3806	310	20	not	not	PART
fnp-3806	310	21	have	have	VERB
fnp-3806	310	22	sps	sps	NOUN
fnp-3806	310	23	or	or	CCONJ
fnp-3806	310	24	β	β	NOUN
fnp-3806	310	25	-	-	ADJ
fnp-3806	310	26	amyloid	amyloid	ADJ
fnp-3806	310	27	deposits	deposit	NOUN
fnp-3806	310	28	(	(	PUNCT
fnp-3806	310	29	41	41	NUM
fnp-3806	310	30	,	,	PUNCT
fnp-3806	310	31	342	342	NUM
fnp-3806	310	32	)	)	PUNCT
fnp-3806	310	33	.	.	PUNCT
fnp-3806	311	1	stages	stage	NOUN
fnp-3806	311	2	0	0	NUM
fnp-3806	311	3	,	,	PUNCT
fnp-3806	311	4	a	a	DET
fnp-3806	311	5	,	,	PUNCT
fnp-3806	311	6	b	b	NOUN
fnp-3806	311	7	,	,	PUNCT
fnp-3806	311	8	c	c	PROPN
fnp-3806	311	9	of	of	ADP
fnp-3806	311	10	braak	braak	NOUN
fnp-3806	311	11	define	define	VERB
fnp-3806	311	12	the	the	DET
fnp-3806	311	13	progression	progression	NOUN
fnp-3806	311	14	of	of	ADP
fnp-3806	311	15	sps	sps	PROPN
fnp-3806	311	16	through	through	ADP
fnp-3806	311	17	the	the	DET
fnp-3806	311	18	neocortex	neocortex	NOUN
fnp-3806	311	19	.	.	PUNCT
fnp-3806	312	1	the	the	DET
fnp-3806	312	2	phases	phase	NOUN
fnp-3806	312	3	of	of	ADP
fnp-3806	312	4	thal	thal	PROPN
fnp-3806	312	5	represent	represent	PROPN
fnp-3806	312	6	,	,	PUNCT
fnp-3806	312	7	from	from	ADP
fnp-3806	312	8	phase	phase	NOUN
fnp-3806	312	9	1	1	NUM
fnp-3806	312	10	to	to	ADP
fnp-3806	312	11	6	6	NUM
fnp-3806	312	12	,	,	PUNCT
fnp-3806	312	13	the	the	DET
fnp-3806	312	14	progressive	progressive	ADJ
fnp-3806	312	15	and	and	CCONJ
fnp-3806	312	16	cumulative	cumulative	ADJ
fnp-3806	312	17	appearance	appearance	NOUN
fnp-3806	312	18	of	of	ADP
fnp-3806	312	19	sps	sps	NOUN
fnp-3806	312	20	from	from	ADP
fnp-3806	312	21	the	the	DET
fnp-3806	312	22	neocortex	neocortex	NOUN
fnp-3806	312	23	,	,	PUNCT
fnp-3806	312	24	allocortex	allocortex	NOUN
fnp-3806	312	25	,	,	PUNCT
fnp-3806	312	26	diencephalic	diencephalic	ADJ
fnp-3806	312	27	nuclei	nucleus	NOUN
fnp-3806	312	28	,	,	PUNCT
fnp-3806	312	29	striatum	striatum	NOUN
fnp-3806	312	30	,	,	PUNCT
fnp-3806	312	31	and	and	CCONJ
fnp-3806	312	32	cholinergic	cholinergic	ADJ
fnp-3806	312	33	nuclei	nucleus	NOUN
fnp-3806	312	34	of	of	ADP
fnp-3806	312	35	the	the	DET
fnp-3806	312	36	basal	basal	ADJ
fnp-3806	312	37	forebrain	forebrain	NOUN
fnp-3806	312	38	,	,	PUNCT
fnp-3806	312	39	the	the	DET
fnp-3806	312	40	brainstem	brainstem	NOUN
fnp-3806	312	41	,	,	PUNCT
fnp-3806	312	42	and	and	CCONJ
fnp-3806	312	43	the	the	DET
fnp-3806	312	44	cerebellum	cerebellum	NOUN
fnp-3806	312	45	(	(	PUNCT
fnp-3806	312	46	343	343	NUM
fnp-3806	312	47	)	)	PUNCT
fnp-3806	312	48	.	.	PUNCT
fnp-3806	313	1	the	the	DET
fnp-3806	313	2	early	early	ADJ
fnp-3806	313	3	appearance	appearance	NOUN
fnp-3806	313	4	of	of	ADP
fnp-3806	313	5	tau	tau	PROPN
fnp-3806	313	6	pathology	pathology	NOUN
fnp-3806	313	7	compared	compare	VERB
fnp-3806	313	8	with	with	ADP
fnp-3806	313	9	the	the	DET
fnp-3806	313	10	later	later	ADJ
fnp-3806	313	11	appearance	appearance	NOUN
fnp-3806	313	12	of	of	ADP
fnp-3806	313	13	β	β	NOUN
fnp-3806	313	14	-	-	ADJ
fnp-3806	313	15	amyloid	amyloid	ADJ
fnp-3806	313	16	plaques	plaque	NOUN
fnp-3806	313	17	in	in	ADP
fnp-3806	313	18	a	a	DET
fnp-3806	313	19	series	series	NOUN
fnp-3806	313	20	of	of	ADP
fnp-3806	313	21	2366	2366	NUM
fnp-3806	313	22	cases	case	NOUN
fnp-3806	313	23	from	from	ADP
fnp-3806	313	24	children	child	NOUN
fnp-3806	313	25	to	to	ADP
fnp-3806	313	26	centenarians	centenarian	NOUN
fnp-3806	313	27	has	have	AUX
fnp-3806	313	28	been	be	AUX
fnp-3806	313	29	recently	recently	ADV
fnp-3806	313	30	revisited	revisit	VERB
fnp-3806	313	31	(	(	PUNCT
fnp-3806	313	32	344	344	NUM
fnp-3806	313	33	)	)	PUNCT
fnp-3806	313	34	.	.	PUNCT
fnp-3806	314	1	based	base	VERB
fnp-3806	314	2	on	on	ADP
fnp-3806	314	3	the	the	DET
fnp-3806	314	4	results	result	NOUN
fnp-3806	314	5	of	of	ADP
fnp-3806	314	6	these	these	DET
fnp-3806	314	7	observations	observation	NOUN
fnp-3806	314	8	and	and	CCONJ
fnp-3806	314	9	many	many	ADJ
fnp-3806	314	10	previous	previous	ADJ
fnp-3806	314	11	studies	study	NOUN
fnp-3806	314	12	,	,	PUNCT
fnp-3806	314	13	the	the	DET
fnp-3806	314	14	paper	paper	NOUN
fnp-3806	314	15	hypothesizes	hypothesize	VERB
fnp-3806	314	16	that	that	PRON
fnp-3806	314	17	tau	tau	PROPN
fnp-3806	314	18	pathology	pathology	NOUN
fnp-3806	314	19	is	be	AUX
fnp-3806	314	20	an	an	DET
fnp-3806	314	21	initiating	initiate	VERB
fnp-3806	314	22	factor	factor	NOUN
fnp-3806	314	23	in	in	ADP
fnp-3806	314	24	sad	sad	ADJ
fnp-3806	314	25	(	(	PUNCT
fnp-3806	314	26	344	344	NUM
fnp-3806	314	27	)	)	PUNCT
fnp-3806	314	28	.	.	PUNCT
fnp-3806	315	1	indeed	indeed	ADV
fnp-3806	315	2	,	,	PUNCT
fnp-3806	315	3	the	the	DET
fnp-3806	315	4	lack	lack	NOUN
fnp-3806	315	5	of	of	ADP
fnp-3806	315	6	temporal	temporal	ADJ
fnp-3806	315	7	and	and	CCONJ
fnp-3806	315	8	regional	regional	ADJ
fnp-3806	315	9	concordance	concordance	NOUN
fnp-3806	315	10	between	between	ADP
fnp-3806	315	11	nfts	nft	NOUN
fnp-3806	315	12	and	and	CCONJ
fnp-3806	315	13	sps	sps	PROPN
fnp-3806	315	14	in	in	ADP
fnp-3806	315	15	sad	sad	ADJ
fnp-3806	315	16	is	be	AUX
fnp-3806	315	17	intuitively	intuitively	ADV
fnp-3806	315	18	barely	barely	ADV
fnp-3806	315	19	consistent	consistent	ADJ
fnp-3806	315	20	with	with	ADP
fnp-3806	315	21	the	the	DET
fnp-3806	315	22	β	β	NOUN
fnp-3806	315	23	-	-	ADJ
fnp-3806	315	24	amyloid	amyloid	ADJ
fnp-3806	315	25	cascade	cascade	NOUN
fnp-3806	315	26	hypothesis	hypothesis	NOUN
fnp-3806	315	27	,	,	PUNCT
fnp-3806	315	28	unless	unless	SCONJ
fnp-3806	315	29	non	non	ADJ
fnp-3806	315	30	-	-	ADJ
fnp-3806	315	31	identified	identify	VERB
fnp-3806	315	32	soluble	soluble	ADJ
fnp-3806	315	33	or	or	CCONJ
fnp-3806	315	34	other	other	ADJ
fnp-3806	315	35	species	specie	NOUN
fnp-3806	315	36	of	of	ADP
fnp-3806	315	37	β	β	NOUN
fnp-3806	315	38	-	-	ADJ
fnp-3806	315	39	amyloid	amyloid	ADJ
fnp-3806	315	40	interact	interact	NOUN
fnp-3806	315	41	with	with	ADP
fnp-3806	315	42	neurons	neuron	NOUN
fnp-3806	315	43	,	,	PUNCT
fnp-3806	315	44	thus	thus	ADV
fnp-3806	315	45	triggering	trigger	VERB
fnp-3806	315	46	nft	nft	PROPN
fnp-3806	315	47	pathology	pathology	PROPN
fnp-3806	315	48	(	(	PUNCT
fnp-3806	315	49	345	345	NUM
fnp-3806	315	50	)	)	PUNCT
fnp-3806	315	51	.	.	PUNCT
fnp-3806	316	1	these	these	DET
fnp-3806	316	2	comments	comment	NOUN
fnp-3806	316	3	do	do	AUX
fnp-3806	316	4	not	not	PART
fnp-3806	316	5	mean	mean	VERB
fnp-3806	316	6	that	that	SCONJ
fnp-3806	316	7	there	there	PRON
fnp-3806	316	8	is	be	VERB
fnp-3806	316	9	no	no	DET
fnp-3806	316	10	interaction	interaction	NOUN
fnp-3806	316	11	between	between	ADP
fnp-3806	316	12	the	the	DET
fnp-3806	316	13	two	two	NUM
fnp-3806	316	14	proteins	protein	NOUN
fnp-3806	316	15	.	.	PUNCT
fnp-3806	317	1	tauopathy	tauopathy	NOUN
fnp-3806	317	2	fuelled	fuel	VERB
fnp-3806	317	3	by	by	ADP
fnp-3806	317	4	β	β	NOUN
fnp-3806	317	5	-	-	NOUN
fnp-3806	317	6	amyloid	amyloid	NOUN
fnp-3806	317	7	in	in	ADP
fnp-3806	317	8	a	a	DET
fnp-3806	317	9	synergetic	synergetic	ADJ
fnp-3806	317	10	mechanism	mechanism	NOUN
fnp-3806	317	11	is	be	AUX
fnp-3806	317	12	well	well	ADV
fnp-3806	317	13	documented	document	VERB
fnp-3806	317	14	in	in	ADP
fnp-3806	317	15	ad	ad	NOUN
fnp-3806	317	16	(	(	PUNCT
fnp-3806	317	17	346	346	NUM
fnp-3806	317	18	-	-	SYM
fnp-3806	317	19	348	348	NUM
fnp-3806	317	20	)	)	PUNCT
fnp-3806	317	21	.	.	PUNCT
fnp-3806	318	1	the	the	DET
fnp-3806	318	2	arguments	argument	NOUN
fnp-3806	318	3	between	between	ADP
fnp-3806	318	4	supporters	supporter	NOUN
fnp-3806	318	5	of	of	ADP
fnp-3806	318	6	β	β	NOUN
fnp-3806	318	7	-	-	NOUN
fnp-3806	318	8	amyloid	amyloid	NOUN
fnp-3806	318	9	and	and	CCONJ
fnp-3806	318	10	of	of	ADP
fnp-3806	318	11	tau	tau	PROPN
fnp-3806	318	12	as	as	ADP
fnp-3806	318	13	the	the	DET
fnp-3806	318	14	primal	primal	ADJ
fnp-3806	318	15	origin	origin	NOUN
fnp-3806	318	16	of	of	ADP
fnp-3806	318	17	sad	sad	ADJ
fnp-3806	318	18	have	have	AUX
fnp-3806	318	19	consumed	consume	VERB
fnp-3806	318	20	a	a	DET
fnp-3806	318	21	great	great	ADJ
fnp-3806	318	22	deal	deal	NOUN
fnp-3806	318	23	of	of	ADP
fnp-3806	318	24	effort	effort	NOUN
fnp-3806	318	25	,	,	PUNCT
fnp-3806	318	26	time	time	NOUN
fnp-3806	318	27	,	,	PUNCT
fnp-3806	318	28	and	and	CCONJ
fnp-3806	318	29	financial	financial	ADJ
fnp-3806	318	30	investment	investment	NOUN
fnp-3806	318	31	(	(	PUNCT
fnp-3806	318	32	349	349	NUM
fnp-3806	318	33	)	)	PUNCT
fnp-3806	318	34	.	.	PUNCT
fnp-3806	319	1	there	there	PRON
fnp-3806	319	2	is	be	VERB
fnp-3806	319	3	no	no	DET
fnp-3806	319	4	doubt	doubt	NOUN
fnp-3806	319	5	about	about	ADP
fnp-3806	319	6	the	the	DET
fnp-3806	319	7	new	new	ADJ
fnp-3806	319	8	acquisition	acquisition	NOUN
fnp-3806	319	9	of	of	ADP
fnp-3806	319	10	knowledge	knowledge	NOUN
fnp-3806	319	11	generated	generate	VERB
fnp-3806	319	12	regarding	regard	VERB
fnp-3806	319	13	sad	sad	ADJ
fnp-3806	319	14	pathogenesis	pathogenesis	NOUN
fnp-3806	319	15	,	,	PUNCT
fnp-3806	319	16	but	but	CCONJ
fnp-3806	319	17	exclusive	exclusive	ADJ
fnp-3806	319	18	hypotheses	hypothesis	NOUN
fnp-3806	319	19	have	have	AUX
fnp-3806	319	20	not	not	PART
fnp-3806	319	21	produced	produce	VERB
fnp-3806	319	22	the	the	DET
fnp-3806	319	23	anticipated	anticipated	ADJ
fnp-3806	319	24	unequivocal	unequivocal	ADJ
fnp-3806	319	25	results	result	NOUN
fnp-3806	319	26	.	.	PUNCT
fnp-3806	320	1	cognitive	cognitive	ADJ
fnp-3806	320	2	impairment	impairment	NOUN
fnp-3806	320	3	and	and	CCONJ
fnp-3806	320	4	dementia	dementia	NOUN
fnp-3806	320	5	correlate	correlate	VERB
fnp-3806	320	6	with	with	ADP
fnp-3806	320	7	tau	tau	PROPN
fnp-3806	320	8	deposition	deposition	NOUN
fnp-3806	320	9	and	and	CCONJ
fnp-3806	320	10	nft	nft	PROPN
fnp-3806	320	11	pathology	pathology	NOUN
fnp-3806	320	12	rather	rather	ADV
fnp-3806	320	13	than	than	ADP
fnp-3806	320	14	with	with	ADP
fnp-3806	320	15	β	β	NOUN
fnp-3806	320	16	-	-	ADJ
fnp-3806	320	17	amyloid	amyloid	ADJ
fnp-3806	320	18	deposits	deposit	NOUN
fnp-3806	320	19	and	and	CCONJ
fnp-3806	320	20	sps	sps	PROPN
fnp-3806	320	21	(	(	PUNCT
fnp-3806	320	22	331	331	NUM
fnp-3806	320	23	,	,	PUNCT
fnp-3806	320	24	350	350	NUM
fnp-3806	320	25	-	-	SYM
fnp-3806	320	26	358	358	NUM
fnp-3806	320	27	)	)	PUNCT
fnp-3806	320	28	.	.	PUNCT
fnp-3806	321	1	neuron	neuron	PROPN
fnp-3806	321	2	loss	loss	NOUN
fnp-3806	321	3	occurs	occur	VERB
fnp-3806	321	4	largely	largely	ADV
fnp-3806	321	5	in	in	ADP
fnp-3806	321	6	parallel	parallel	NOUN
fnp-3806	321	7	with	with	ADP
fnp-3806	321	8	tau	tau	PROPN
fnp-3806	321	9	pathology	pathology	NOUN
fnp-3806	321	10	rather	rather	ADV
fnp-3806	321	11	than	than	ADP
fnp-3806	321	12	with	with	ADP
fnp-3806	321	13	sps	sps	NOUN
fnp-3806	321	14	in	in	ADP
fnp-3806	321	15	most	most	ADJ
fnp-3806	321	16	regions	region	NOUN
fnp-3806	321	17	(	(	PUNCT
fnp-3806	321	18	359	359	NUM
fnp-3806	321	19	)	)	PUNCT
fnp-3806	321	20	.	.	PUNCT
fnp-3806	322	1	however	however	ADV
fnp-3806	322	2	,	,	PUNCT
fnp-3806	322	3	neuron	neuron	VERB
fnp-3806	322	4	degeneration	degeneration	NOUN
fnp-3806	322	5	and	and	CCONJ
fnp-3806	322	6	neuron	neuron	PROPN
fnp-3806	322	7	loss	loss	NOUN
fnp-3806	322	8	are	be	AUX
fnp-3806	322	9	not	not	PART
fnp-3806	322	10	restricted	restrict	VERB
fnp-3806	322	11	to	to	ADP
fnp-3806	322	12	neurons	neuron	NOUN
fnp-3806	322	13	with	with	ADP
fnp-3806	322	14	nfts	nft	NOUN
fnp-3806	322	15	(	(	PUNCT
fnp-3806	322	16	see	see	VERB
fnp-3806	322	17	section	section	NOUN
fnp-3806	322	18	10	10	NUM
fnp-3806	322	19	)	)	PUNCT
fnp-3806	322	20	.	.	PUNCT
fnp-3806	323	1	recently	recently	ADV
fnp-3806	323	2	,	,	PUNCT
fnp-3806	323	3	a	a	DET
fnp-3806	323	4	classification	classification	NOUN
fnp-3806	323	5	of	of	ADP
fnp-3806	323	6	ad	ad	NOUN
fnp-3806	323	7	has	have	AUX
fnp-3806	323	8	been	be	AUX
fnp-3806	323	9	proposed	propose	VERB
fnp-3806	323	10	:	:	PUNCT
fnp-3806	323	11	ad	ad	NOUN
fnp-3806	323	12	autosomal	autosomal	ADJ
fnp-3806	323	13	dominant	dominant	ADJ
fnp-3806	323	14	(	(	PUNCT
fnp-3806	323	15	fad	fad	NOUN
fnp-3806	323	16	)	)	PUNCT
fnp-3806	323	17	,	,	PUNCT
fnp-3806	323	18	apoeε4	apoeε4	PROPN
fnp-3806	323	19	sad	sad	ADJ
fnp-3806	323	20	,	,	PUNCT
fnp-3806	323	21	and	and	CCONJ
fnp-3806	323	22	non	non	ADJ
fnp-3806	323	23	-	-	ADJ
fnp-3806	323	24	apoeε4	apoeε4	ADJ
fnp-3806	323	25	sad	sad	ADJ
fnp-3806	323	26	(	(	PUNCT
fnp-3806	323	27	360	360	NUM
fnp-3806	323	28	)	)	PUNCT
fnp-3806	323	29	.	.	PUNCT
fnp-3806	324	1	this	this	DET
fnp-3806	324	2	categorization	categorization	NOUN
fnp-3806	324	3	is	be	AUX
fnp-3806	324	4	not	not	PART
fnp-3806	324	5	new	new	ADJ
fnp-3806	324	6	,	,	PUNCT
fnp-3806	324	7	but	but	CCONJ
fnp-3806	324	8	rather	rather	ADV
fnp-3806	324	9	recovers	recover	NOUN
fnp-3806	324	10	and	and	CCONJ
fnp-3806	324	11	further	far	ADV
fnp-3806	324	12	emphasizes	emphasize	VERB
fnp-3806	324	13	the	the	DET
fnp-3806	324	14	well	well	ADV
fnp-3806	324	15	-	-	PUNCT
fnp-3806	324	16	known	know	VERB
fnp-3806	324	17	relative	relative	ADJ
fnp-3806	324	18	importance	importance	NOUN
fnp-3806	324	19	of	of	ADP
fnp-3806	324	20	β	β	NOUN
fnp-3806	324	21	-	-	NOUN
fnp-3806	324	22	amyloid	amyloid	ADJ
fnp-3806	324	23	deposition	deposition	NOUN
fnp-3806	324	24	in	in	ADP
fnp-3806	324	25	the	the	DET
fnp-3806	324	26	different	different	ADJ
fnp-3806	324	27	ad	ad	NOUN
fnp-3806	324	28	categories	category	NOUN
fnp-3806	324	29	depending	depend	VERB
fnp-3806	324	30	on	on	ADP
fnp-3806	324	31	genetic	genetic	ADJ
fnp-3806	324	32	factors	factor	NOUN
fnp-3806	324	33	involved	involve	VERB
fnp-3806	324	34	in	in	ADP
fnp-3806	324	35	the	the	DET
fnp-3806	324	36	production	production	NOUN
fnp-3806	324	37	of	of	ADP
fnp-3806	324	38	β	β	NOUN
fnp-3806	324	39	-	-	NOUN
fnp-3806	324	40	amyloid	amyloid	NOUN
fnp-3806	324	41	.	.	PUNCT
fnp-3806	325	1	5	5	NUM
fnp-3806	325	2	.	.	NOUN
fnp-3806	325	3	nfts	nft	NOUN
fnp-3806	325	4	and	and	CCONJ
fnp-3806	325	5	sps	sps	PROPN
fnp-3806	325	6	in	in	ADP
fnp-3806	325	7	non	non	ADJ
fnp-3806	325	8	-	-	ADJ
fnp-3806	325	9	human	human	ADJ
fnp-3806	325	10	brain	brain	NOUN
fnp-3806	325	11	aging	age	VERB
fnp-3806	325	12	β	β	NOUN
fnp-3806	325	13	-	-	ADJ
fnp-3806	325	14	amyloid	amyloid	ADJ
fnp-3806	325	15	plaques	plaque	NOUN
fnp-3806	325	16	and	and	CCONJ
fnp-3806	325	17	β	β	NOUN
fnp-3806	325	18	-	-	NOUN
fnp-3806	325	19	amyloid	amyloid	ADJ
fnp-3806	325	20	angiopathy	angiopathy	NOUN
fnp-3806	325	21	may	may	AUX
fnp-3806	325	22	be	be	AUX
fnp-3806	325	23	found	find	VERB
fnp-3806	325	24	in	in	ADP
fnp-3806	325	25	old	old	ADJ
fnp-3806	325	26	-	-	PUNCT
fnp-3806	325	27	aged	aged	ADJ
fnp-3806	325	28	animals	animal	NOUN
fnp-3806	325	29	in	in	ADP
fnp-3806	325	30	some	some	DET
fnp-3806	325	31	species	specie	NOUN
fnp-3806	325	32	including	include	VERB
fnp-3806	325	33	non	non	ADJ
fnp-3806	325	34	-	-	ADJ
fnp-3806	325	35	human	human	ADJ
fnp-3806	325	36	primates	primate	NOUN
fnp-3806	325	37	,	,	PUNCT
fnp-3806	325	38	monkeys	monkey	NOUN
fnp-3806	325	39	,	,	PUNCT
fnp-3806	325	40	dolphins	dolphin	NOUN
fnp-3806	325	41	and	and	CCONJ
fnp-3806	325	42	other	other	ADJ
fnp-3806	325	43	cetaceans	cetacean	NOUN
fnp-3806	325	44	,	,	PUNCT
fnp-3806	325	45	dogs	dog	NOUN
fnp-3806	325	46	,	,	PUNCT
fnp-3806	325	47	cats	cat	NOUN
fnp-3806	325	48	,	,	PUNCT
fnp-3806	325	49	bears	bear	NOUN
fnp-3806	325	50	,	,	PUNCT
fnp-3806	325	51	and	and	CCONJ
fnp-3806	325	52	pinniped	pinniped	VERB
fnp-3806	325	53	species	specie	NOUN
fnp-3806	325	54	,	,	PUNCT
fnp-3806	325	55	among	among	ADP
fnp-3806	325	56	others	other	NOUN
fnp-3806	325	57	;	;	PUNCT
fnp-3806	325	58	deposits	deposit	NOUN
fnp-3806	325	59	are	be	AUX
fnp-3806	325	60	usually	usually	ADV
fnp-3806	325	61	diffuse	diffuse	ADJ
fnp-3806	325	62	whereas	whereas	SCONJ
fnp-3806	325	63	core	core	ADJ
fnp-3806	325	64	plaques	plaque	NOUN
fnp-3806	325	65	surrounded	surround	VERB
fnp-3806	325	66	by	by	ADP
fnp-3806	325	67	tau	tau	PROPN
fnp-3806	325	68	-	-	PUNCT
fnp-3806	325	69	containing	contain	VERB
fnp-3806	325	70	dystrophic	dystrophic	ADJ
fnp-3806	325	71	neurites	neurite	NOUN
fnp-3806	325	72	are	be	AUX
fnp-3806	325	73	exceptional	exceptional	ADJ
fnp-3806	325	74	(	(	PUNCT
fnp-3806	325	75	361	361	NUM
fnp-3806	325	76	-	-	SYM
fnp-3806	325	77	372	372	NUM
fnp-3806	325	78	)	)	PUNCT
fnp-3806	325	79	.	.	PUNCT
fnp-3806	326	1	phosphorylated	phosphorylate	VERB
fnp-3806	326	2	-	-	PUNCT
fnp-3806	326	3	tau	tau	PROPN
fnp-3806	326	4	deposits	deposit	NOUN
fnp-3806	326	5	in	in	ADP
fnp-3806	326	6	neurons	neuron	NOUN
fnp-3806	326	7	are	be	AUX
fnp-3806	326	8	rarely	rarely	ADV
fnp-3806	326	9	encountered	encounter	VERB
fnp-3806	326	10	in	in	ADP
fnp-3806	326	11	most	most	ADJ
fnp-3806	326	12	mammals	mammal	NOUN
fnp-3806	326	13	,	,	PUNCT
fnp-3806	326	14	and	and	CCONJ
fnp-3806	326	15	they	they	PRON
fnp-3806	326	16	usually	usually	ADV
fnp-3806	326	17	have	have	VERB
fnp-3806	326	18	the	the	DET
fnp-3806	326	19	characteristics	characteristic	NOUN
fnp-3806	326	20	of	of	ADP
fnp-3806	326	21	pre	pre	NOUN
fnp-3806	326	22	-	-	NOUN
fnp-3806	326	23	tangles	tangle	NOUN
fnp-3806	326	24	rather	rather	ADV
fnp-3806	326	25	than	than	ADP
fnp-3806	326	26	nfts	nft	NOUN
fnp-3806	326	27	,	,	PUNCT
fnp-3806	326	28	as	as	ADP
fnp-3806	326	29	in	in	ADP
fnp-3806	326	30	a	a	DET
fnp-3806	326	31	few	few	ADJ
fnp-3806	326	32	vulnerable	vulnerable	ADJ
fnp-3806	326	33	aged	aged	ADJ
fnp-3806	326	34	mouse	mouse	NOUN
fnp-3806	326	35	lemurs	lemur	NOUN
fnp-3806	326	36	(	(	PUNCT
fnp-3806	326	37	362	362	NUM
fnp-3806	326	38	)	)	PUNCT
fnp-3806	326	39	.	.	PUNCT
fnp-3806	327	1	intracytoplasmic	intracytoplasmic	PROPN
fnp-3806	327	2	tau	tau	PROPN
fnp-3806	327	3	inclusions	inclusion	NOUN
fnp-3806	327	4	in	in	ADP
fnp-3806	327	5	neurons	neuron	NOUN
fnp-3806	327	6	,	,	PUNCT
fnp-3806	327	7	astrocytes	astrocyte	NOUN
fnp-3806	327	8	,	,	PUNCT
fnp-3806	327	9	and	and	CCONJ
fnp-3806	327	10	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	327	11	may	may	AUX
fnp-3806	327	12	occur	occur	VERB
fnp-3806	327	13	in	in	ADP
fnp-3806	327	14	aged	aged	ADJ
fnp-3806	327	15	baboons	baboon	NOUN
fnp-3806	327	16	(	(	PUNCT
fnp-3806	327	17	373	373	NUM
fnp-3806	327	18	,	,	PUNCT
fnp-3806	327	19	374	374	NUM
fnp-3806	327	20	)	)	PUNCT
fnp-3806	327	21	,	,	PUNCT
fnp-3806	327	22	aged	aged	ADJ
fnp-3806	327	23	gorillas	gorilla	NOUN
fnp-3806	327	24	(	(	PUNCT
fnp-3806	327	25	369	369	NUM
fnp-3806	327	26	)	)	PUNCT
fnp-3806	327	27	,	,	PUNCT
fnp-3806	327	28	and	and	CCONJ
fnp-3806	327	29	chimpanzees	chimpanzee	NOUN
fnp-3806	327	30	(	(	PUNCT
fnp-3806	327	31	371	371	NUM
fnp-3806	327	32	)	)	PUNCT
fnp-3806	327	33	.	.	PUNCT
fnp-3806	328	1	tau	tau	PROPN
fnp-3806	328	2	accumulation	accumulation	NOUN
fnp-3806	328	3	in	in	ADP
fnp-3806	328	4	the	the	DET
fnp-3806	328	5	brain	brain	NOUN
fnp-3806	328	6	of	of	ADP
fnp-3806	328	7	old	old	ADJ
fnp-3806	328	8	sea	sea	NOUN
fnp-3806	328	9	lions	lion	NOUN
fnp-3806	328	10	,	,	PUNCT
fnp-3806	328	11	seals	seal	NOUN
fnp-3806	328	12	,	,	PUNCT
fnp-3806	328	13	and	and	CCONJ
fnp-3806	328	14	walruses	walrus	NOUN
fnp-3806	328	15	forms	form	NOUN
fnp-3806	328	16	argyrophilic	argyrophilic	ADJ
fnp-3806	328	17	fibrillar	fibrillar	X
fnp-3806	328	18	3rtau	3rtau	NUM
fnp-3806	328	19	and	and	CCONJ
fnp-3806	328	20	4rtau	4rtau	NUM
fnp-3806	328	21	aggregates	aggregate	NOUN
fnp-3806	328	22	in	in	ADP
fnp-3806	328	23	the	the	DET
fnp-3806	328	24	neuronal	neuronal	ADJ
fnp-3806	328	25	somata	somata	NOUN
fnp-3806	328	26	and	and	CCONJ
fnp-3806	328	27	neurites	neurite	NOUN
fnp-3806	328	28	,	,	PUNCT
fnp-3806	328	29	and	and	CCONJ
fnp-3806	328	30	olny	olny	ADJ
fnp-3806	328	31	few	few	ADJ
fnp-3806	328	32	tau	tau	PROPN
fnp-3806	328	33	aggregates	aggregate	NOUN
fnp-3806	328	34	are	be	AUX
fnp-3806	328	35	found	find	VERB
fnp-3806	328	36	in	in	ADP
fnp-3806	328	37	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	328	38	and	and	CCONJ
fnp-3806	328	39	microglia	microglia	ADJ
fnp-3806	328	40	(	(	PUNCT
fnp-3806	328	41	372	372	NUM
fnp-3806	328	42	)	)	PUNCT
fnp-3806	328	43	.	.	PUNCT
fnp-3806	329	1	importantly	importantly	ADV
fnp-3806	329	2	,	,	PUNCT
fnp-3806	329	3	these	these	DET
fnp-3806	329	4	changes	change	NOUN
fnp-3806	329	5	are	be	AUX
fnp-3806	329	6	linked	link	VERB
fnp-3806	329	7	to	to	ADP
fnp-3806	329	8	aging	age	VERB
fnp-3806	329	9	,	,	PUNCT
fnp-3806	329	10	but	but	CCONJ
fnp-3806	329	11	they	they	PRON
fnp-3806	329	12	are	be	AUX
fnp-3806	329	13	not	not	PART
fnp-3806	329	14	the	the	DET
fnp-3806	329	15	only	only	ADJ
fnp-3806	329	16	expression	expression	NOUN
fnp-3806	329	17	of	of	ADP
fnp-3806	329	18	brain	brain	NOUN
fnp-3806	329	19	aging	aging	NOUN
fnp-3806	329	20	(	(	PUNCT
fnp-3806	329	21	375	375	NUM
fnp-3806	329	22	,	,	PUNCT
fnp-3806	329	23	376	376	NUM
fnp-3806	329	24	)	)	PUNCT
fnp-3806	329	25	.	.	PUNCT
fnp-3806	330	1	hyperphosphorylated	hyperphosphorylate	VERB
fnp-3806	330	2	tau	tau	PROPN
fnp-3806	330	3	accumulation	accumulation	NOUN
fnp-3806	330	4	in	in	ADP
fnp-3806	330	5	neurons	neuron	NOUN
fnp-3806	330	6	,	,	PUNCT
fnp-3806	330	7	intraneuronal	intraneuronal	ADJ
fnp-3806	330	8	β	β	NOUN
fnp-3806	330	9	-	-	ADJ
fnp-3806	330	10	amyloid	amyloid	ADJ
fnp-3806	330	11	deposits	deposit	NOUN
fnp-3806	330	12	,	,	PUNCT
fnp-3806	330	13	and	and	CCONJ
fnp-3806	330	14	diffuse	diffuse	VERB
fnp-3806	330	15	amyloid	amyloid	NOUN
fnp-3806	330	16	plaques	plaque	NOUN
fnp-3806	330	17	may	may	AUX
fnp-3806	330	18	occur	occur	VERB
fnp-3806	330	19	in	in	ADP
fnp-3806	330	20	the	the	DET
fnp-3806	330	21	brain	brain	NOUN
fnp-3806	330	22	of	of	ADP
fnp-3806	330	23	aged	aged	ADJ
fnp-3806	330	24	domestic	domestic	ADJ
fnp-3806	330	25	cats	cat	NOUN
fnp-3806	330	26	(	(	PUNCT
fnp-3806	330	27	377	377	NUM
fnp-3806	330	28	,	,	PUNCT
fnp-3806	330	29	378	378	NUM
fnp-3806	330	30	)	)	PUNCT
fnp-3806	330	31	.	.	PUNCT
fnp-3806	331	1	the	the	DET
fnp-3806	331	2	characteristics	characteristic	NOUN
fnp-3806	331	3	and	and	CCONJ
fnp-3806	331	4	distribution	distribution	NOUN
fnp-3806	331	5	of	of	ADP
fnp-3806	331	6	tau	tau	PROPN
fnp-3806	331	7	lesions	lesion	NOUN
fnp-3806	331	8	in	in	ADP
fnp-3806	331	9	a	a	DET
fnp-3806	331	10	few	few	ADJ
fnp-3806	331	11	cats	cat	NOUN
fnp-3806	331	12	are	be	AUX
fnp-3806	331	13	reminiscent	reminiscent	ADJ
fnp-3806	331	14	of	of	ADP
fnp-3806	331	15	sad	sad	ADJ
fnp-3806	331	16	including	include	VERB
fnp-3806	331	17	the	the	DET
fnp-3806	331	18	deposition	deposition	NOUN
fnp-3806	331	19	of	of	ADP
fnp-3806	331	20	4rtau	4rtau	NUM
fnp-3806	331	21	and	and	CCONJ
fnp-3806	331	22	3rtau	3rtau	NUM
fnp-3806	331	23	(	(	PUNCT
fnp-3806	331	24	379	379	NUM
fnp-3806	331	25	)	)	PUNCT
fnp-3806	331	26	.	.	PUNCT
fnp-3806	332	1	a	a	DET
fnp-3806	332	2	unique	unique	ADJ
fnp-3806	332	3	4rtauopathy	4rtauopathy	NUM
fnp-3806	332	4	without	without	ADP
fnp-3806	332	5	β	β	NOUN
fnp-3806	332	6	-	-	NOUN
fnp-3806	332	7	amyloid	amyloid	ADJ
fnp-3806	332	8	deposits	deposit	NOUN
fnp-3806	332	9	mainly	mainly	ADV
fnp-3806	332	10	involving	involve	VERB
fnp-3806	332	11	neurons	neuron	NOUN
fnp-3806	332	12	of	of	ADP
fnp-3806	332	13	the	the	DET
fnp-3806	332	14	neocortex	neocortex	NOUN
fnp-3806	332	15	but	but	CCONJ
fnp-3806	332	16	not	not	PART
fnp-3806	332	17	the	the	DET
fnp-3806	332	18	hippocampus	hippocampus	NOUN
fnp-3806	332	19	,	,	PUNCT
fnp-3806	332	20	accompanied	accompany	VERB
fnp-3806	332	21	by	by	ADP
fnp-3806	332	22	widespread	widespread	ADJ
fnp-3806	332	23	coiled	coil	VERB
fnp-3806	332	24	bodies	body	NOUN
fnp-3806	332	25	in	in	ADP
fnp-3806	332	26	the	the	DET
fnp-3806	332	27	cerebral	cerebral	ADJ
fnp-3806	332	28	white	white	ADJ
fnp-3806	332	29	matter	matter	NOUN
fnp-3806	332	30	,	,	PUNCT
fnp-3806	332	31	has	have	AUX
fnp-3806	332	32	been	be	AUX
fnp-3806	332	33	reported	report	VERB
fnp-3806	332	34	in	in	ADP
fnp-3806	332	35	aged	aged	ADJ
fnp-3806	332	36	domestic	domestic	ADJ
fnp-3806	332	37	cats	cat	NOUN
fnp-3806	332	38	(	(	PUNCT
fnp-3806	332	39	380	380	NUM
fnp-3806	332	40	)	)	PUNCT
fnp-3806	332	41	.	.	PUNCT
fnp-3806	333	1	these	these	DET
fnp-3806	333	2	observations	observation	NOUN
fnp-3806	333	3	show	show	VERB
fnp-3806	333	4	that	that	SCONJ
fnp-3806	333	5	β	β	X
fnp-3806	333	6	-	-	ADJ
fnp-3806	333	7	amyloid	amyloid	ADJ
fnp-3806	333	8	deposition	deposition	NOUN
fnp-3806	333	9	and	and	CCONJ
fnp-3806	333	10	tau	tau	PROPN
fnp-3806	333	11	pathology	pathology	NOUN
fnp-3806	333	12	may	may	AUX
fnp-3806	333	13	occur	occur	VERB
fnp-3806	333	14	with	with	ADP
fnp-3806	333	15	high	high	ADJ
fnp-3806	333	16	species	specie	NOUN
fnp-3806	333	17	variability	variability	NOUN
fnp-3806	333	18	,	,	PUNCT
fnp-3806	333	19	in	in	ADP
fnp-3806	333	20	aged	aged	ADJ
fnp-3806	333	21	mammals	mammal	NOUN
fnp-3806	333	22	,	,	PUNCT
fnp-3806	333	23	and	and	CCONJ
fnp-3806	333	24	,	,	PUNCT
fnp-3806	333	25	particularly	particularly	ADV
fnp-3806	333	26	,	,	PUNCT
fnp-3806	333	27	in	in	ADP
fnp-3806	333	28	non	non	ADJ
fnp-3806	333	29	-	-	ADJ
fnp-3806	333	30	human	human	ADJ
fnp-3806	333	31	primates	primate	NOUN
fnp-3806	333	32	and	and	CCONJ
fnp-3806	333	33	pinnipeds	pinniped	NOUN
fnp-3806	333	34	.	.	PUNCT
fnp-3806	334	1	however	however	ADV
fnp-3806	334	2	,	,	PUNCT
fnp-3806	334	3	we	we	PRON
fnp-3806	334	4	do	do	AUX
fnp-3806	334	5	not	not	PART
fnp-3806	334	6	have	have	VERB
fnp-3806	334	7	evidence	evidence	NOUN
fnp-3806	334	8	at	at	ADP
fnp-3806	334	9	present	present	NOUN
fnp-3806	334	10	on	on	ADP
fnp-3806	334	11	whether	whether	SCONJ
fnp-3806	334	12	these	these	DET
fnp-3806	334	13	species	specie	NOUN
fnp-3806	334	14	show	show	VERB
fnp-3806	334	15	changes	change	NOUN
fnp-3806	334	16	in	in	ADP
fnp-3806	334	17	the	the	DET
fnp-3806	334	18	same	same	ADJ
fnp-3806	334	19	way	way	NOUN
fnp-3806	334	20	as	as	ADP
fnp-3806	334	21	human	human	ADJ
fnp-3806	334	22	beings	being	NOUN
fnp-3806	334	23	.	.	PUNCT
fnp-3806	335	1	in	in	ADP
fnp-3806	335	2	aged	aged	ADJ
fnp-3806	335	3	cynomolgus	cynomolgus	ADJ
fnp-3806	335	4	monkeys	monkey	NOUN
fnp-3806	335	5	,	,	PUNCT
fnp-3806	335	6	β	β	X
fnp-3806	335	7	-	-	ADJ
fnp-3806	335	8	amyloid	amyloid	ADJ
fnp-3806	335	9	plaques	plaque	NOUN
fnp-3806	335	10	combine	combine	VERB
fnp-3806	335	11	with	with	ADP
fnp-3806	335	12	4rtau	4rtau	NUM
fnp-3806	335	13	deposits	deposit	NOUN
fnp-3806	335	14	in	in	ADP
fnp-3806	335	15	pre	pre	ADJ
fnp-3806	335	16	-	-	ADJ
fnp-3806	335	17	tangle	tangle	ADJ
fnp-3806	335	18	neurons	neuron	NOUN
fnp-3806	335	19	and	and	CCONJ
fnp-3806	335	20	coiled	coil	VERB
fnp-3806	335	21	bodies	body	NOUN
fnp-3806	335	22	in	in	ADP
fnp-3806	335	23	glial	glial	ADJ
fnp-3806	335	24	cells	cell	NOUN
fnp-3806	335	25	with	with	ADP
fnp-3806	335	26	a	a	DET
fnp-3806	335	27	regional	regional	ADJ
fnp-3806	335	28	pattern	pattern	NOUN
fnp-3806	335	29	reminiscent	reminiscent	ADJ
fnp-3806	335	30	of	of	ADP
fnp-3806	335	31	progressive	progressive	ADJ
fnp-3806	335	32	supranuclear	supranuclear	ADJ
fnp-3806	335	33	palsy	palsy	ADJ
fnp-3806	335	34	(	(	PUNCT
fnp-3806	335	35	370	370	NUM
fnp-3806	335	36	)	)	PUNCT
fnp-3806	335	37	.	.	PUNCT
fnp-3806	336	1	therefore	therefore	ADV
fnp-3806	336	2	,	,	PUNCT
fnp-3806	336	3	the	the	DET
fnp-3806	336	4	old	old	ADJ
fnp-3806	336	5	hypothesis	hypothesis	NOUN
fnp-3806	336	6	suggesting	suggest	VERB
fnp-3806	336	7	that	that	SCONJ
fnp-3806	336	8	sad	sad	ADJ
fnp-3806	336	9	is	be	AUX
fnp-3806	336	10	a	a	DET
fnp-3806	336	11	phylogenetic	phylogenetic	ADJ
fnp-3806	336	12	disease	disease	NOUN
fnp-3806	336	13	(	(	PUNCT
fnp-3806	336	14	381	381	NUM
fnp-3806	336	15	)	)	PUNCT
fnp-3806	336	16	has	have	VERB
fnp-3806	336	17	a	a	DET
fnp-3806	336	18	relative	relative	ADJ
fnp-3806	336	19	relevance	relevance	NOUN
fnp-3806	336	20	unless	unless	SCONJ
fnp-3806	336	21	applied	apply	VERB
fnp-3806	336	22	to	to	ADP
fnp-3806	336	23	the	the	DET
fnp-3806	336	24	search	search	NOUN
fnp-3806	336	25	for	for	ADP
fnp-3806	336	26	mechanisms	mechanism	NOUN
fnp-3806	336	27	modulating	modulate	VERB
fnp-3806	336	28	similarities	similarity	NOUN
fnp-3806	336	29	and	and	CCONJ
fnp-3806	336	30	differences	difference	NOUN
fnp-3806	336	31	between	between	ADP
fnp-3806	336	32	non	non	NOUN
fnp-3806	336	33	-	-	NOUN
fnp-3806	336	34	humans	human	NOUN
fnp-3806	336	35	and	and	CCONJ
fnp-3806	336	36	humans	human	NOUN
fnp-3806	336	37	regarding	regard	VERB
fnp-3806	336	38	the	the	DET
fnp-3806	336	39	tremendous	tremendous	ADJ
fnp-3806	336	40	prevalence	prevalence	NOUN
fnp-3806	336	41	,	,	PUNCT
fnp-3806	336	42	widespread	widespread	ADJ
fnp-3806	336	43	localization	localization	NOUN
fnp-3806	336	44	,	,	PUNCT
fnp-3806	336	45	particular	particular	ADJ
fnp-3806	336	46	regional	regional	ADJ
fnp-3806	336	47	distribution	distribution	NOUN
fnp-3806	336	48	,	,	PUNCT
fnp-3806	336	49	and	and	CCONJ
fnp-3806	336	50	composition	composition	NOUN
fnp-3806	336	51	and	and	CCONJ
fnp-3806	336	52	structure	structure	NOUN
fnp-3806	336	53	of	of	ADP
fnp-3806	336	54	tau	tau	PROPN
fnp-3806	336	55	deposits	deposit	NOUN
fnp-3806	336	56	in	in	ADP
fnp-3806	336	57	humans	human	NOUN
fnp-3806	336	58	in	in	ADP
fnp-3806	336	59	comparison	comparison	NOUN
fnp-3806	336	60	with	with	ADP
fnp-3806	336	61	other	other	ADJ
fnp-3806	336	62	species	specie	NOUN
fnp-3806	336	63	.	.	PUNCT
fnp-3806	337	1	6	6	X
fnp-3806	337	2	.	.	X
fnp-3806	337	3	synapses	synapse	VERB
fnp-3806	337	4	synaptic	synaptic	ADJ
fnp-3806	337	5	alterations	alteration	NOUN
fnp-3806	337	6	were	be	AUX
fnp-3806	337	7	described	describe	VERB
fnp-3806	337	8	in	in	ADP
fnp-3806	337	9	the	the	DET
fnp-3806	337	10	1960s	1960	NOUN
fnp-3806	337	11	in	in	ADP
fnp-3806	337	12	the	the	DET
fnp-3806	337	13	seminal	seminal	ADJ
fnp-3806	337	14	electron	electron	NOUN
fnp-3806	337	15	microscopic	microscopic	ADJ
fnp-3806	337	16	studies	study	NOUN
fnp-3806	337	17	of	of	ADP
fnp-3806	337	18	ad	ad	NOUN
fnp-3806	337	19	(	(	PUNCT
fnp-3806	337	20	382	382	NUM
fnp-3806	337	21	)	)	PUNCT
fnp-3806	337	22	.	.	PUNCT
fnp-3806	338	1	these	these	DET
fnp-3806	338	2	findings	finding	NOUN
fnp-3806	338	3	were	be	AUX
fnp-3806	338	4	followed	follow	VERB
fnp-3806	338	5	by	by	ADP
fnp-3806	338	6	the	the	DET
fnp-3806	338	7	observation	observation	NOUN
fnp-3806	338	8	of	of	ADP
fnp-3806	338	9	decreased	decrease	VERB
fnp-3806	338	10	numbers	number	NOUN
fnp-3806	338	11	of	of	ADP
fnp-3806	338	12	dendritic	dendritic	ADJ
fnp-3806	338	13	spines	spine	NOUN
fnp-3806	338	14	on	on	ADP
fnp-3806	338	15	cortical	cortical	ADJ
fnp-3806	338	16	neurons	neuron	NOUN
fnp-3806	338	17	assessed	assess	VERB
fnp-3806	338	18	with	with	ADP
fnp-3806	338	19	the	the	DET
fnp-3806	338	20	golgi	golgi	NOUN
fnp-3806	338	21	method	method	NOUN
fnp-3806	338	22	in	in	ADP
fnp-3806	338	23	post	post	ADJ
fnp-3806	338	24	-	-	ADJ
fnp-3806	338	25	mortem	mortem	ADJ
fnp-3806	338	26	and	and	CCONJ
fnp-3806	338	27	biopsy	biopsy	NOUN
fnp-3806	338	28	samples	sample	NOUN
fnp-3806	338	29	at	at	ADP
fnp-3806	338	30	a	a	DET
fnp-3806	338	31	time	time	NOUN
fnp-3806	338	32	when	when	SCONJ
fnp-3806	338	33	cerebral	cerebral	ADJ
fnp-3806	338	34	biopsies	biopsy	NOUN
fnp-3806	338	35	were	be	AUX
fnp-3806	338	36	still	still	ADV
fnp-3806	338	37	considered	consider	VERB
fnp-3806	338	38	appropriate	appropriate	ADJ
fnp-3806	338	39	tools	tool	NOUN
fnp-3806	338	40	for	for	ADP
fnp-3806	338	41	diagnosis	diagnosis	NOUN
fnp-3806	338	42	of	of	ADP
fnp-3806	338	43	dementia	dementia	NOUN
fnp-3806	338	44	(	(	PUNCT
fnp-3806	338	45	383	383	NUM
fnp-3806	338	46	-	-	SYM
fnp-3806	338	47	389	389	NUM
fnp-3806	338	48	)	)	PUNCT
fnp-3806	338	49	.	.	PUNCT
fnp-3806	339	1	synaptic	synaptic	ADJ
fnp-3806	339	2	loss	loss	NOUN
fnp-3806	339	3	is	be	AUX
fnp-3806	339	4	the	the	DET
fnp-3806	339	5	major	major	ADJ
fnp-3806	339	6	morphological	morphological	ADJ
fnp-3806	339	7	correlate	correlate	NOUN
fnp-3806	339	8	of	of	ADP
fnp-3806	339	9	cognitive	cognitive	ADJ
fnp-3806	339	10	impairment	impairment	NOUN
fnp-3806	339	11	(	(	PUNCT
fnp-3806	339	12	390	390	NUM
fnp-3806	339	13	)	)	PUNCT
fnp-3806	339	14	.	.	PUNCT
fnp-3806	340	1	for	for	ADP
fnp-3806	340	2	this	this	DET
fnp-3806	340	3	reason	reason	NOUN
fnp-3806	340	4	,	,	PUNCT
fnp-3806	340	5	ad	ad	NOUN
fnp-3806	340	6	is	be	AUX
fnp-3806	340	7	considered	consider	VERB
fnp-3806	340	8	as	as	ADP
fnp-3806	340	9	the	the	DET
fnp-3806	340	10	consequence	consequence	NOUN
fnp-3806	340	11	of	of	ADP
fnp-3806	340	12	a	a	DET
fnp-3806	340	13	synaptic	synaptic	ADJ
fnp-3806	340	14	failure	failure	NOUN
fnp-3806	340	15	(	(	PUNCT
fnp-3806	340	16	391	391	NUM
fnp-3806	340	17	)	)	PUNCT
fnp-3806	340	18	.	.	PUNCT
fnp-3806	341	1	subsequent	subsequent	ADJ
fnp-3806	341	2	studies	study	NOUN
fnp-3806	341	3	have	have	AUX
fnp-3806	341	4	refined	refine	VERB
fnp-3806	341	5	synaptic	synaptic	ADJ
fnp-3806	341	6	alterations	alteration	NOUN
fnp-3806	341	7	using	use	VERB
fnp-3806	341	8	different	different	ADJ
fnp-3806	341	9	methods	method	NOUN
fnp-3806	341	10	(	(	PUNCT
fnp-3806	341	11	392	392	NUM
fnp-3806	341	12	;	;	PUNCT
fnp-3806	341	13	393	393	NUM
fnp-3806	341	14	)	)	PUNCT
fnp-3806	341	15	,	,	PUNCT
fnp-3806	341	16	including	include	VERB
fnp-3806	341	17	the	the	DET
fnp-3806	341	18	use	use	NOUN
fnp-3806	341	19	of	of	ADP
fnp-3806	341	20	intraneuronal	intraneuronal	ADJ
fnp-3806	341	21	dyes	dye	NOUN
fnp-3806	341	22	in	in	ADP
fnp-3806	341	23	post	post	ADJ
fnp-3806	341	24	-	-	ADJ
fnp-3806	341	25	mortem	mortem	ADJ
fnp-3806	341	26	tissues	tissue	NOUN
fnp-3806	341	27	(	(	PUNCT
fnp-3806	341	28	394	394	NUM
fnp-3806	341	29	,	,	PUNCT
fnp-3806	341	30	395	395	NUM
fnp-3806	341	31	)	)	PUNCT
fnp-3806	341	32	.	.	PUNCT
fnp-3806	342	1	the	the	DET
fnp-3806	342	2	golgi	golgi	PROPN
fnp-3806	342	3	method	method	NOUN
fnp-3806	342	4	also	also	ADV
fnp-3806	342	5	provided	provide	VERB
fnp-3806	342	6	evidence	evidence	NOUN
fnp-3806	342	7	of	of	ADP
fnp-3806	342	8	dendritic	dendritic	ADJ
fnp-3806	342	9	degeneration	degeneration	NOUN
fnp-3806	342	10	and	and	CCONJ
fnp-3806	342	11	dendritic	dendritic	ADJ
fnp-3806	342	12	sprouting	sprouting	NOUN
fnp-3806	342	13	and	and	CCONJ
fnp-3806	342	14	re	re	NOUN
fnp-3806	342	15	-	-	NOUN
fnp-3806	342	16	growth	growth	NOUN
fnp-3806	342	17	in	in	ADP
fnp-3806	342	18	several	several	ADJ
fnp-3806	342	19	brain	brain	NOUN
fnp-3806	342	20	regions	region	NOUN
fnp-3806	342	21	in	in	ADP
fnp-3806	342	22	ad	ad	NOUN
fnp-3806	342	23	(	(	PUNCT
fnp-3806	342	24	396	396	NUM
fnp-3806	342	25	-	-	SYM
fnp-3806	342	26	401	401	NUM
fnp-3806	342	27	)	)	PUNCT
fnp-3806	342	28	.	.	PUNCT
fnp-3806	343	1	dendritic	dendritic	ADJ
fnp-3806	343	2	sprouting	sprouting	NOUN
fnp-3806	343	3	is	be	AUX
fnp-3806	343	4	reinforced	reinforce	VERB
fnp-3806	343	5	by	by	ADP
fnp-3806	343	6	the	the	DET
fnp-3806	343	7	presence	presence	NOUN
fnp-3806	343	8	of	of	ADP
fnp-3806	343	9	growth	growth	NOUN
fnp-3806	343	10	-	-	PUNCT
fnp-3806	343	11	associated	associate	VERB
fnp-3806	343	12	protein	protein	NOUN
fnp-3806	343	13	43	43	NUM
fnp-3806	343	14	(	(	PUNCT
fnp-3806	343	15	gap-43	gap-43	PROPN
fnp-3806	343	16	)	)	PUNCT
fnp-3806	343	17	,	,	PUNCT
fnp-3806	343	18	a	a	DET
fnp-3806	343	19	marker	marker	NOUN
fnp-3806	343	20	of	of	ADP
fnp-3806	343	21	neuritic	neuritic	ADJ
fnp-3806	343	22	growth	growth	NOUN
fnp-3806	343	23	and	and	CCONJ
fnp-3806	343	24	sprouting	sprout	VERB
fnp-3806	343	25	around	around	ADP
fnp-3806	343	26	sps	sps	NOUN
fnp-3806	343	27	(	(	PUNCT
fnp-3806	343	28	143	143	NUM
fnp-3806	343	29	,	,	PUNCT
fnp-3806	343	30	402	402	NUM
fnp-3806	343	31	)	)	PUNCT
fnp-3806	343	32	.	.	PUNCT
fnp-3806	344	1	aberrant	aberrant	ADJ
fnp-3806	344	2	sprouting	sprouting	NOUN
fnp-3806	344	3	seems	seem	VERB
fnp-3806	344	4	to	to	PART
fnp-3806	344	5	be	be	AUX
fnp-3806	344	6	triggered	trigger	VERB
fnp-3806	344	7	by	by	ADP
fnp-3806	344	8	pre	pre	ADJ
fnp-3806	344	9	-	-	ADJ
fnp-3806	344	10	amyloid	amyloid	ADJ
fnp-3806	344	11	species	specie	NOUN
fnp-3806	344	12	and	and	CCONJ
fnp-3806	344	13	neurotrophic	neurotrophic	ADJ
fnp-3806	344	14	factors	factor	NOUN
fnp-3806	344	15	(	(	PUNCT
fnp-3806	344	16	401	401	NUM
fnp-3806	344	17	)	)	PUNCT
fnp-3806	344	18	.	.	PUNCT
fnp-3806	345	1	aberrant	aberrant	ADJ
fnp-3806	345	2	sprouting	sprouting	NOUN
fnp-3806	345	3	involves	involve	VERB
fnp-3806	345	4	neurites	neurite	NOUN
fnp-3806	345	5	,	,	PUNCT
fnp-3806	345	6	dendrites	dendrite	NOUN
fnp-3806	345	7	,	,	PUNCT
fnp-3806	345	8	and	and	CCONJ
fnp-3806	345	9	synapses	synapsis	NOUN
fnp-3806	345	10	,	,	PUNCT
fnp-3806	345	11	and	and	CCONJ
fnp-3806	345	12	it	it	PRON
fnp-3806	345	13	affects	affect	VERB
fnp-3806	345	14	distinct	distinct	ADJ
fnp-3806	345	15	connections	connection	NOUN
fnp-3806	345	16	in	in	ADP
fnp-3806	345	17	ad	ad	NOUN
fnp-3806	345	18	(	(	PUNCT
fnp-3806	345	19	401	401	NUM
fnp-3806	345	20	)	)	PUNCT
fnp-3806	345	21	.	.	PUNCT
fnp-3806	346	1	cycles	cycle	NOUN
fnp-3806	346	2	of	of	ADP
fnp-3806	346	3	aberrant	aberrant	ADJ
fnp-3806	346	4	synaptic	synaptic	ADJ
fnp-3806	346	5	sprouting	sprouting	NOUN
fnp-3806	346	6	and	and	CCONJ
fnp-3806	346	7	neurodegeneration	neurodegeneration	NOUN
fnp-3806	346	8	are	be	AUX
fnp-3806	346	9	common	common	ADJ
fnp-3806	346	10	in	in	ADP
fnp-3806	346	11	ad	ad	NOUN
fnp-3806	346	12	(	(	PUNCT
fnp-3806	346	13	403	403	NUM
fnp-3806	346	14	)	)	PUNCT
fnp-3806	346	15	.	.	PUNCT
fnp-3806	347	1	spine	spine	ADJ
fnp-3806	347	2	loss	loss	NOUN
fnp-3806	347	3	occurs	occur	VERB
fnp-3806	347	4	mainly	mainly	ADV
fnp-3806	347	5	in	in	ADP
fnp-3806	347	6	clusters	cluster	NOUN
fnp-3806	347	7	linked	link	VERB
fnp-3806	347	8	to	to	ADP
fnp-3806	347	9	tau	tau	PROPN
fnp-3806	347	10	pathology	pathology	NOUN
fnp-3806	347	11	(	(	PUNCT
fnp-3806	347	12	404	404	NUM
fnp-3806	347	13	,	,	PUNCT
fnp-3806	347	14	405	405	NUM
fnp-3806	347	15	)	)	PUNCT
fnp-3806	347	16	.	.	PUNCT
fnp-3806	348	1	immunohistochemistry	immunohistochemistry	PROPN
fnp-3806	348	2	also	also	ADV
fnp-3806	348	3	reveals	reveal	VERB
fnp-3806	348	4	altered	altered	ADJ
fnp-3806	348	5	expression	expression	NOUN
fnp-3806	348	6	of	of	ADP
fnp-3806	348	7	synaptic	synaptic	ADJ
fnp-3806	348	8	markers	marker	NOUN
fnp-3806	348	9	not	not	PART
fnp-3806	348	10	only	only	ADV
fnp-3806	348	11	around	around	ADP
fnp-3806	348	12	sps	sps	PROPN
fnp-3806	348	13	but	but	CCONJ
fnp-3806	348	14	also	also	ADV
fnp-3806	348	15	in	in	ADP
fnp-3806	348	16	diffuse	diffuse	ADJ
fnp-3806	348	17	plaques	plaque	NOUN
fnp-3806	348	18	,	,	PUNCT
fnp-3806	348	19	suggesting	suggest	VERB
fnp-3806	348	20	a	a	DET
fnp-3806	348	21	close	close	ADJ
fnp-3806	348	22	relationship	relationship	NOUN
fnp-3806	348	23	between	between	ADP
fnp-3806	348	24	synapses	synapsis	NOUN
fnp-3806	348	25	and	and	CCONJ
fnp-3806	348	26	β	β	NOUN
fnp-3806	348	27	-	-	ADJ
fnp-3806	348	28	amyloid	amyloid	ADJ
fnp-3806	348	29	deposition	deposition	NOUN
fnp-3806	348	30	(	(	PUNCT
fnp-3806	348	31	129	129	NUM
fnp-3806	348	32	,	,	PUNCT
fnp-3806	348	33	406	406	NUM
fnp-3806	348	34	,	,	PUNCT
fnp-3806	348	35	407	407	NUM
fnp-3806	348	36	)	)	PUNCT
fnp-3806	348	37	.	.	PUNCT
fnp-3806	349	1	abnormal	abnormal	ADJ
fnp-3806	349	2	preand	preand	VERB
fnp-3806	349	3	post	post	ADJ
fnp-3806	349	4	-	-	ADJ
fnp-3806	349	5	synaptic	synaptic	ADJ
fnp-3806	349	6	tau	tau	NOUN
fnp-3806	349	7	and	and	CCONJ
fnp-3806	349	8	tau	tau	PROPN
fnp-3806	349	9	oligomers	oligomer	NOUN
fnp-3806	349	10	damage	damage	VERB
fnp-3806	349	11	the	the	DET
fnp-3806	349	12	synapses	synapsis	NOUN
fnp-3806	349	13	and	and	CCONJ
fnp-3806	349	14	produce	produce	VERB
fnp-3806	349	15	altered	alter	VERB
fnp-3806	349	16	synaptic	synaptic	ADJ
fnp-3806	349	17	function	function	NOUN
fnp-3806	349	18	(	(	PUNCT
fnp-3806	349	19	150	150	NUM
fnp-3806	349	20	,	,	PUNCT
fnp-3806	349	21	408	408	NUM
fnp-3806	349	22	,	,	PUNCT
fnp-3806	349	23	409	409	NUM
fnp-3806	349	24	)	)	PUNCT
fnp-3806	349	25	.	.	PUNCT
fnp-3806	350	1	double	double	ADJ
fnp-3806	350	2	-	-	PUNCT
fnp-3806	350	3	labeling	labeling	NOUN
fnp-3806	350	4	of	of	ADP
fnp-3806	350	5	neurons	neuron	NOUN
fnp-3806	350	6	also	also	ADV
fnp-3806	350	7	shows	show	VERB
fnp-3806	350	8	a	a	DET
fnp-3806	350	9	direct	direct	ADJ
fnp-3806	350	10	relationship	relationship	NOUN
fnp-3806	350	11	between	between	ADP
fnp-3806	350	12	tau	tau	PROPN
fnp-3806	350	13	deposition	deposition	NOUN
fnp-3806	350	14	and	and	CCONJ
fnp-3806	350	15	loss	loss	NOUN
fnp-3806	350	16	of	of	ADP
fnp-3806	350	17	dendritic	dendritic	ADJ
fnp-3806	350	18	spines	spine	NOUN
fnp-3806	350	19	on	on	ADP
fnp-3806	350	20	cortical	cortical	ADJ
fnp-3806	350	21	pyramidal	pyramidal	ADJ
fnp-3806	350	22	neurons	neuron	NOUN
fnp-3806	350	23	in	in	ADP
fnp-3806	350	24	ad	ad	NOUN
fnp-3806	350	25	(	(	PUNCT
fnp-3806	350	26	404	404	NUM
fnp-3806	350	27	)	)	PUNCT
fnp-3806	350	28	.	.	PUNCT
fnp-3806	351	1	abnormal	abnormal	ADJ
fnp-3806	351	2	tau	tau	PROPN
fnp-3806	351	3	and	and	CCONJ
fnp-3806	351	4	β	β	NOUN
fnp-3806	351	5	-	-	NOUN
fnp-3806	351	6	amyloid	amyloid	ADJ
fnp-3806	351	7	oligomers	oligomer	NOUN
fnp-3806	351	8	act	act	VERB
fnp-3806	351	9	synergistically	synergistically	ADV
fnp-3806	351	10	to	to	PART
fnp-3806	351	11	disrupt	disrupt	VERB
fnp-3806	351	12	synaptic	synaptic	ADJ
fnp-3806	351	13	function	function	NOUN
fnp-3806	351	14	(	(	PUNCT
fnp-3806	351	15	409	409	NUM
fnp-3806	351	16	)	)	PUNCT
fnp-3806	351	17	.	.	PUNCT
fnp-3806	352	1	however	however	ADV
fnp-3806	352	2	,	,	PUNCT
fnp-3806	352	3	synaptic	synaptic	ADJ
fnp-3806	352	4	loss	loss	NOUN
fnp-3806	352	5	also	also	ADV
fnp-3806	352	6	appears	appear	VERB
fnp-3806	352	7	not	not	PART
fnp-3806	352	8	to	to	PART
fnp-3806	352	9	be	be	AUX
fnp-3806	352	10	dependent	dependent	ADJ
fnp-3806	352	11	on	on	ADP
fnp-3806	352	12	fibrillar	fibrillar	ADJ
fnp-3806	352	13	β	β	NOUN
fnp-3806	352	14	-	-	NOUN
fnp-3806	352	15	amyloid	amyloid	NOUN
fnp-3806	352	16	in	in	ADP
fnp-3806	352	17	a	a	DET
fnp-3806	352	18	murine	murine	ADJ
fnp-3806	352	19	model	model	NOUN
fnp-3806	352	20	of	of	ADP
fnp-3806	352	21	β	β	NOUN
fnp-3806	352	22	-	-	ADJ
fnp-3806	352	23	amyloid	amyloid	ADJ
fnp-3806	352	24	deposition	deposition	NOUN
fnp-3806	352	25	(	(	PUNCT
fnp-3806	352	26	149	149	NUM
fnp-3806	352	27	)	)	PUNCT
fnp-3806	352	28	.	.	PUNCT
fnp-3806	353	1	abnormal	abnormal	ADJ
fnp-3806	353	2	neuronal	neuronal	ADJ
fnp-3806	353	3	expression	expression	NOUN
fnp-3806	353	4	of	of	ADP
fnp-3806	353	5	app	app	NOUN
fnp-3806	353	6	and	and	CCONJ
fnp-3806	353	7	cytoskeletal	cytoskeletal	ADJ
fnp-3806	353	8	proteins	protein	NOUN
fnp-3806	353	9	in	in	ADP
fnp-3806	353	10	early	early	ADJ
fnp-3806	353	11	stages	stage	NOUN
fnp-3806	353	12	of	of	ADP
fnp-3806	353	13	the	the	DET
fnp-3806	353	14	disease	disease	NOUN
fnp-3806	353	15	might	might	AUX
fnp-3806	353	16	be	be	AUX
fnp-3806	353	17	involved	involve	VERB
fnp-3806	353	18	in	in	ADP
fnp-3806	353	19	the	the	DET
fnp-3806	353	20	mechanisms	mechanism	NOUN
fnp-3806	353	21	of	of	ADP
fnp-3806	353	22	synaptic	synaptic	ADJ
fnp-3806	353	23	pathology	pathology	NOUN
fnp-3806	353	24	in	in	ADP
fnp-3806	353	25	ad	ad	NOUN
fnp-3806	353	26	(	(	PUNCT
fnp-3806	353	27	410	410	NUM
fnp-3806	353	28	)	)	PUNCT
fnp-3806	353	29	.	.	PUNCT
fnp-3806	354	1	synaptic	synaptic	ADJ
fnp-3806	354	2	proteins	protein	NOUN
fnp-3806	354	3	are	be	AUX
fnp-3806	354	4	important	important	ADJ
fnp-3806	354	5	components	component	NOUN
fnp-3806	354	6	associated	associate	VERB
fnp-3806	354	7	with	with	ADP
fnp-3806	354	8	β	β	NOUN
fnp-3806	354	9	-	-	NOUN
fnp-3806	354	10	amyloid	amyloid	NOUN
fnp-3806	354	11	in	in	ADP
fnp-3806	354	12	sps	sps	PROPN
fnp-3806	354	13	(	(	PUNCT
fnp-3806	354	14	127	127	NUM
fnp-3806	354	15	)	)	PUNCT
fnp-3806	354	16	.	.	PUNCT
fnp-3806	355	1	it	it	PRON
fnp-3806	355	2	has	have	AUX
fnp-3806	355	3	recently	recently	ADV
fnp-3806	355	4	been	be	AUX
fnp-3806	355	5	postulated	postulate	VERB
fnp-3806	355	6	that	that	SCONJ
fnp-3806	355	7	altered	alter	VERB
fnp-3806	355	8	synapses	synapsis	NOUN
fnp-3806	355	9	are	be	AUX
fnp-3806	355	10	the	the	DET
fnp-3806	355	11	origin	origin	NOUN
fnp-3806	355	12	of	of	ADP
fnp-3806	355	13	amyloid	amyloid	NOUN
fnp-3806	355	14	plaques	plaque	NOUN
fnp-3806	355	15	in	in	ADP
fnp-3806	355	16	ad	ad	NOUN
fnp-3806	355	17	(	(	PUNCT
fnp-3806	355	18	411	411	NUM
fnp-3806	355	19	;	;	PUNCT
fnp-3806	355	20	see	see	VERB
fnp-3806	355	21	also	also	ADV
fnp-3806	355	22	section	section	NOUN
fnp-3806	355	23	2a	2a	NUM
fnp-3806	355	24	)	)	PUNCT
fnp-3806	355	25	.	.	PUNCT
fnp-3806	356	1	both	both	PRON
fnp-3806	356	2	β	β	NOUN
fnp-3806	356	3	-	-	PUNCT
fnp-3806	356	4	amyloid	amyloid	NOUN
fnp-3806	356	5	and	and	CCONJ
fnp-3806	356	6	abnormal	abnormal	ADJ
fnp-3806	356	7	tau	tau	PROPN
fnp-3806	356	8	are	be	AUX
fnp-3806	356	9	accumulated	accumulate	VERB
fnp-3806	356	10	at	at	ADP
fnp-3806	356	11	the	the	DET
fnp-3806	356	12	synapses	synapsis	NOUN
fnp-3806	356	13	(	(	PUNCT
fnp-3806	356	14	412	412	NUM
fnp-3806	356	15	-	-	SYM
fnp-3806	356	16	421	421	NUM
fnp-3806	356	17	)	)	PUNCT
fnp-3806	356	18	.	.	PUNCT
fnp-3806	357	1	recent	recent	ADJ
fnp-3806	357	2	neuroimaging	neuroimage	VERB
fnp-3806	357	3	studies	study	NOUN
fnp-3806	357	4	further	far	ADV
fnp-3806	357	5	support	support	VERB
fnp-3806	357	6	the	the	DET
fnp-3806	357	7	association	association	NOUN
fnp-3806	357	8	of	of	ADP
fnp-3806	357	9	tau	tau	PROPN
fnp-3806	357	10	pathology	pathology	PROPN
fnp-3806	357	11	,	,	PUNCT
fnp-3806	357	12	synaptic	synaptic	ADJ
fnp-3806	357	13	loss	loss	NOUN
fnp-3806	357	14	,	,	PUNCT
fnp-3806	357	15	and	and	CCONJ
fnp-3806	357	16	altered	alter	VERB
fnp-3806	357	17	synaptic	synaptic	ADJ
fnp-3806	357	18	function	function	NOUN
fnp-3806	357	19	(	(	PUNCT
fnp-3806	357	20	422	422	NUM
fnp-3806	357	21	)	)	PUNCT
fnp-3806	357	22	.	.	PUNCT
fnp-3806	358	1	it	it	PRON
fnp-3806	358	2	has	have	AUX
fnp-3806	358	3	been	be	AUX
fnp-3806	358	4	proposed	propose	VERB
fnp-3806	358	5	that	that	SCONJ
fnp-3806	358	6	synaptic	synaptic	ADJ
fnp-3806	358	7	tau	tau	PROPN
fnp-3806	358	8	pathology	pathology	NOUN
fnp-3806	358	9	is	be	AUX
fnp-3806	358	10	an	an	DET
fnp-3806	358	11	early	early	ADJ
fnp-3806	358	12	event	event	NOUN
fnp-3806	358	13	,	,	PUNCT
fnp-3806	358	14	and	and	CCONJ
fnp-3806	358	15	synaptic	synaptic	ADJ
fnp-3806	358	16	tau	tau	NOUN
fnp-3806	358	17	seeding	seed	VERB
fnp-3806	358	18	precedes	precede	VERB
fnp-3806	358	19	tau	tau	PROPN
fnp-3806	358	20	pathology	pathology	NOUN
fnp-3806	358	21	in	in	ADP
fnp-3806	358	22	sad	sad	ADJ
fnp-3806	358	23	(	(	PUNCT
fnp-3806	358	24	423	423	NUM
fnp-3806	358	25	)	)	PUNCT
fnp-3806	358	26	.	.	PUNCT
fnp-3806	359	1	other	other	ADJ
fnp-3806	359	2	factors	factor	NOUN
fnp-3806	359	3	are	be	AUX
fnp-3806	359	4	also	also	ADV
fnp-3806	359	5	important	important	ADJ
fnp-3806	359	6	such	such	ADJ
fnp-3806	359	7	as	as	ADP
fnp-3806	359	8	cytoskeletal	cytoskeletal	ADJ
fnp-3806	359	9	actin	actin	NOUN
fnp-3806	359	10	dysregulation	dysregulation	NOUN
fnp-3806	359	11	(	(	PUNCT
fnp-3806	359	12	424	424	NUM
fnp-3806	359	13	)	)	PUNCT
fnp-3806	359	14	,	,	PUNCT
fnp-3806	359	15	and	and	CCONJ
fnp-3806	359	16	oxidative	oxidative	ADJ
fnp-3806	359	17	stress	stress	NOUN
fnp-3806	359	18	lipid	lipid	NOUN
fnp-3806	359	19	and	and	CCONJ
fnp-3806	359	20	protein	protein	NOUN
fnp-3806	359	21	damage	damage	NOUN
fnp-3806	359	22	(	(	PUNCT
fnp-3806	359	23	425	425	NUM
fnp-3806	359	24	)	)	PUNCT
fnp-3806	359	25	.	.	PUNCT
fnp-3806	360	1	no	no	PRON
fnp-3806	360	2	less	less	ADV
fnp-3806	360	3	significant	significant	ADJ
fnp-3806	360	4	is	be	AUX
fnp-3806	360	5	the	the	DET
fnp-3806	360	6	association	association	NOUN
fnp-3806	360	7	between	between	ADP
fnp-3806	360	8	cell	cell	NOUN
fnp-3806	360	9	-	-	PUNCT
fnp-3806	360	10	cycle	cycle	NOUN
fnp-3806	360	11	dysfunction	dysfunction	NOUN
fnp-3806	360	12	and	and	CCONJ
fnp-3806	360	13	failure	failure	NOUN
fnp-3806	360	14	of	of	ADP
fnp-3806	360	15	synaptic	synaptic	ADJ
fnp-3806	360	16	plasticity	plasticity	NOUN
fnp-3806	360	17	in	in	ADP
fnp-3806	360	18	ad	ad	NOUN
fnp-3806	360	19	(	(	PUNCT
fnp-3806	360	20	426	426	NUM
fnp-3806	360	21	)	)	PUNCT
fnp-3806	360	22	.	.	PUNCT
fnp-3806	361	1	synaptic	synaptic	ADJ
fnp-3806	361	2	alterations	alteration	NOUN
fnp-3806	361	3	include	include	VERB
fnp-3806	361	4	abnormalities	abnormality	NOUN
fnp-3806	361	5	in	in	ADP
fnp-3806	361	6	the	the	DET
fnp-3806	361	7	synaptic	synaptic	ADJ
fnp-3806	361	8	and	and	CCONJ
fnp-3806	361	9	postsynaptic	postsynaptic	ADJ
fnp-3806	361	10	delivery	delivery	NOUN
fnp-3806	361	11	of	of	ADP
fnp-3806	361	12	neurotransmitters	neurotransmitter	NOUN
fnp-3806	361	13	and	and	CCONJ
fnp-3806	361	14	neuromodulators	neuromodulator	NOUN
fnp-3806	361	15	,	,	PUNCT
fnp-3806	361	16	and	and	CCONJ
fnp-3806	361	17	the	the	DET
fnp-3806	361	18	selective	selective	ADJ
fnp-3806	361	19	vulnerability	vulnerability	NOUN
fnp-3806	361	20	and	and	CCONJ
fnp-3806	361	21	responses	response	NOUN
fnp-3806	361	22	of	of	ADP
fnp-3806	361	23	their	their	PRON
fnp-3806	361	24	receptors	receptor	NOUN
fnp-3806	361	25	(	(	PUNCT
fnp-3806	361	26	see	see	VERB
fnp-3806	361	27	section	section	NOUN
fnp-3806	361	28	7	7	NUM
fnp-3806	361	29	)	)	PUNCT
fnp-3806	361	30	.	.	PUNCT
fnp-3806	362	1	finally	finally	ADV
fnp-3806	362	2	,	,	PUNCT
fnp-3806	362	3	lipid	lipid	NOUN
fnp-3806	362	4	and	and	CCONJ
fnp-3806	362	5	protein	protein	NOUN
fnp-3806	362	6	alterations	alteration	NOUN
fnp-3806	362	7	at	at	ADP
fnp-3806	362	8	the	the	DET
fnp-3806	362	9	cell	cell	NOUN
fnp-3806	362	10	membrane	membrane	NOUN
fnp-3806	362	11	,	,	PUNCT
fnp-3806	362	12	and	and	CCONJ
fnp-3806	362	13	altered	alter	VERB
fnp-3806	362	14	cytoskeletal	cytoskeletal	ADJ
fnp-3806	362	15	proteins	protein	NOUN
fnp-3806	362	16	,	,	PUNCT
fnp-3806	362	17	may	may	AUX
fnp-3806	362	18	affect	affect	VERB
fnp-3806	362	19	synaptic	synaptic	ADJ
fnp-3806	362	20	integrity	integrity	NOUN
fnp-3806	362	21	and	and	CCONJ
fnp-3806	362	22	function	function	NOUN
fnp-3806	362	23	(	(	PUNCT
fnp-3806	362	24	see	see	VERB
fnp-3806	362	25	sections	section	NOUN
fnp-3806	362	26	22c	22c	NOUN
fnp-3806	362	27	and	and	CCONJ
fnp-3806	362	28	22h	22h	NUM
fnp-3806	362	29	)	)	PUNCT
fnp-3806	362	30	.	.	PUNCT
fnp-3806	363	1	in	in	ADP
fnp-3806	363	2	addition	addition	NOUN
fnp-3806	363	3	,	,	PUNCT
fnp-3806	363	4	synapses	synapsis	NOUN
fnp-3806	363	5	are	be	AUX
fnp-3806	363	6	organelles	organelle	NOUN
fnp-3806	363	7	with	with	ADP
fnp-3806	363	8	high	high	ADJ
fnp-3806	363	9	energy	energy	NOUN
fnp-3806	363	10	consumption	consumption	NOUN
fnp-3806	363	11	,	,	PUNCT
fnp-3806	363	12	and	and	CCONJ
fnp-3806	363	13	therefore	therefore	ADV
fnp-3806	363	14	they	they	PRON
fnp-3806	363	15	are	be	AUX
fnp-3806	363	16	vulnerable	vulnerable	ADJ
fnp-3806	363	17	to	to	ADP
fnp-3806	363	18	deficits	deficit	NOUN
fnp-3806	363	19	in	in	ADP
fnp-3806	363	20	energy	energy	NOUN
fnp-3806	363	21	production	production	NOUN
fnp-3806	363	22	linked	link	VERB
fnp-3806	363	23	to	to	ADP
fnp-3806	363	24	mitochondrial	mitochondrial	ADJ
fnp-3806	363	25	failure	failure	NOUN
fnp-3806	363	26	(	(	PUNCT
fnp-3806	363	27	427	427	NUM
fnp-3806	363	28	)	)	PUNCT
fnp-3806	363	29	(	(	PUNCT
fnp-3806	363	30	see	see	VERB
fnp-3806	363	31	section	section	NOUN
fnp-3806	363	32	22d	22d	NOUN
fnp-3806	363	33	)	)	PUNCT
fnp-3806	363	34	.	.	PUNCT
fnp-3806	364	1	7	7	X
fnp-3806	364	2	.	.	X
fnp-3806	364	3	neurotransmitters	neurotransmitter	NOUN
fnp-3806	364	4	,	,	PUNCT
fnp-3806	364	5	neuromodulators	neuromodulator	NOUN
fnp-3806	364	6	,	,	PUNCT
fnp-3806	364	7	and	and	CCONJ
fnp-3806	364	8	related	related	ADJ
fnp-3806	364	9	receptors	receptor	NOUN
fnp-3806	364	10	an	an	DET
fnp-3806	364	11	early	early	ADJ
fnp-3806	364	12	relevant	relevant	ADJ
fnp-3806	364	13	biochemical	biochemical	ADJ
fnp-3806	364	14	observation	observation	NOUN
fnp-3806	364	15	was	be	AUX
fnp-3806	364	16	the	the	DET
fnp-3806	364	17	discovery	discovery	NOUN
fnp-3806	364	18	of	of	ADP
fnp-3806	364	19	the	the	DET
fnp-3806	364	20	involvement	involvement	NOUN
fnp-3806	364	21	of	of	ADP
fnp-3806	364	22	the	the	DET
fnp-3806	364	23	meynert	meynert	PROPN
fnp-3806	364	24	nucleus	nucleus	NOUN
fnp-3806	364	25	in	in	ADP
fnp-3806	364	26	ad	ad	NOUN
fnp-3806	364	27	,	,	PUNCT
fnp-3806	364	28	the	the	DET
fnp-3806	364	29	correlation	correlation	NOUN
fnp-3806	364	30	of	of	ADP
fnp-3806	364	31	this	this	DET
fnp-3806	364	32	involvement	involvement	NOUN
fnp-3806	364	33	with	with	ADP
fnp-3806	364	34	the	the	DET
fnp-3806	364	35	number	number	NOUN
fnp-3806	364	36	of	of	ADP
fnp-3806	364	37	plaques	plaque	NOUN
fnp-3806	364	38	and	and	CCONJ
fnp-3806	364	39	cognitive	cognitive	ADJ
fnp-3806	364	40	impairment	impairment	NOUN
fnp-3806	364	41	,	,	PUNCT
fnp-3806	364	42	and	and	CCONJ
fnp-3806	364	43	the	the	DET
fnp-3806	364	44	accompanying	accompanying	ADJ
fnp-3806	364	45	impairment	impairment	NOUN
fnp-3806	364	46	of	of	ADP
fnp-3806	364	47	cholinergic	cholinergic	ADJ
fnp-3806	364	48	innervation	innervation	NOUN
fnp-3806	364	49	in	in	ADP
fnp-3806	364	50	the	the	DET
fnp-3806	364	51	cerebral	cerebral	ADJ
fnp-3806	364	52	cortex	cortex	NOUN
fnp-3806	364	53	(	(	PUNCT
fnp-3806	364	54	428	428	NUM
fnp-3806	364	55	-	-	SYM
fnp-3806	364	56	430	430	NUM
fnp-3806	364	57	)	)	PUNCT
fnp-3806	364	58	.	.	PUNCT
fnp-3806	365	1	the	the	DET
fnp-3806	365	2	“	"	PUNCT
fnp-3806	365	3	cholinergic	cholinergic	ADJ
fnp-3806	365	4	hypothesis	hypothesis	NOUN
fnp-3806	365	5	”	"	PUNCT
fnp-3806	365	6	stated	state	VERB
fnp-3806	365	7	that	that	SCONJ
fnp-3806	365	8	ad	ad	NOUN
fnp-3806	365	9	was	be	AUX
fnp-3806	365	10	a	a	DET
fnp-3806	365	11	disorder	disorder	NOUN
fnp-3806	365	12	of	of	ADP
fnp-3806	365	13	cholinergic	cholinergic	ADJ
fnp-3806	365	14	innervations	innervation	NOUN
fnp-3806	365	15	(	(	PUNCT
fnp-3806	365	16	430	430	NUM
fnp-3806	365	17	,	,	PUNCT
fnp-3806	365	18	431	431	NUM
fnp-3806	365	19	)	)	PUNCT
fnp-3806	365	20	.	.	PUNCT
fnp-3806	366	1	the	the	DET
fnp-3806	366	2	enthusiasm	enthusiasm	NOUN
fnp-3806	366	3	for	for	ADP
fnp-3806	366	4	the	the	DET
fnp-3806	366	5	cholinergic	cholinergic	ADJ
fnp-3806	366	6	theory	theory	NOUN
fnp-3806	366	7	was	be	AUX
fnp-3806	366	8	supported	support	VERB
fnp-3806	366	9	by	by	ADP
fnp-3806	366	10	the	the	DET
fnp-3806	366	11	prior	prior	ADJ
fnp-3806	366	12	discovery	discovery	NOUN
fnp-3806	366	13	of	of	ADP
fnp-3806	366	14	dopamine	dopamine	NOUN
fnp-3806	366	15	deficiency	deficiency	NOUN
fnp-3806	366	16	in	in	ADP
fnp-3806	366	17	the	the	DET
fnp-3806	366	18	substantia	substantia	NOUN
fnp-3806	366	19	nigra	nigra	PROPN
fnp-3806	366	20	pars	par	NOUN
fnp-3806	366	21	compacta	compacta	NOUN
fnp-3806	366	22	in	in	ADP
fnp-3806	366	23	parkinson	parkinson	NOUN
fnp-3806	366	24	’s	’s	PART
fnp-3806	366	25	disease	disease	NOUN
fnp-3806	366	26	,	,	PUNCT
fnp-3806	366	27	and	and	CCONJ
fnp-3806	366	28	the	the	DET
fnp-3806	366	29	success	success	NOUN
fnp-3806	366	30	of	of	ADP
fnp-3806	366	31	l	l	NOUN
fnp-3806	366	32	-	-	PUNCT
fnp-3806	366	33	dopa	dopa	NOUN
fnp-3806	366	34	treatment	treatment	NOUN
fnp-3806	366	35	for	for	ADP
fnp-3806	366	36	this	this	DET
fnp-3806	366	37	disorder	disorder	NOUN
fnp-3806	366	38	which	which	PRON
fnp-3806	366	39	is	be	AUX
fnp-3806	366	40	still	still	ADV
fnp-3806	366	41	in	in	ADP
fnp-3806	366	42	use	use	NOUN
fnp-3806	366	43	50	50	NUM
fnp-3806	366	44	years	year	NOUN
fnp-3806	366	45	later	later	ADV
fnp-3806	366	46	(	(	PUNCT
fnp-3806	366	47	432	432	NUM
fnp-3806	366	48	)	)	PUNCT
fnp-3806	366	49	.	.	PUNCT
fnp-3806	367	1	cholinergic	cholinergic	ADJ
fnp-3806	367	2	drugs	drug	NOUN
fnp-3806	367	3	were	be	AUX
fnp-3806	367	4	used	use	VERB
fnp-3806	367	5	although	although	SCONJ
fnp-3806	367	6	their	their	PRON
fnp-3806	367	7	benefits	benefit	NOUN
fnp-3806	367	8	were	be	AUX
fnp-3806	367	9	clearly	clearly	ADV
fnp-3806	367	10	lower	low	ADJ
fnp-3806	367	11	than	than	SCONJ
fnp-3806	367	12	initially	initially	ADV
fnp-3806	367	13	expected	expect	VERB
fnp-3806	367	14	.	.	PUNCT
fnp-3806	368	1	later	later	ADV
fnp-3806	368	2	,	,	PUNCT
fnp-3806	368	3	the	the	DET
fnp-3806	368	4	glutamatergic	glutamatergic	ADJ
fnp-3806	368	5	theory	theory	NOUN
fnp-3806	368	6	stated	state	VERB
fnp-3806	368	7	that	that	SCONJ
fnp-3806	368	8	excitotoxicity	excitotoxicity	NOUN
fnp-3806	368	9	resulting	result	VERB
fnp-3806	368	10	from	from	ADP
fnp-3806	368	11	excessive	excessive	ADJ
fnp-3806	368	12	synaptic	synaptic	ADJ
fnp-3806	368	13	or	or	CCONJ
fnp-3806	368	14	extrasynaptic	extrasynaptic	ADJ
fnp-3806	368	15	activation	activation	NOUN
fnp-3806	368	16	of	of	ADP
fnp-3806	368	17	n	n	CCONJ
fnp-3806	368	18	-	-	PUNCT
fnp-3806	368	19	methyl	methyl	NOUN
fnp-3806	368	20	-	-	PUNCT
fnp-3806	368	21	d	d	NOUN
fnp-3806	368	22	-	-	NOUN
fnp-3806	368	23	aspartate	aspartate	ADJ
fnp-3806	368	24	(	(	PUNCT
fnp-3806	368	25	nmda	nmda	ADJ
fnp-3806	368	26	)	)	PUNCT
fnp-3806	368	27	subtype	subtype	NOUN
fnp-3806	368	28	of	of	ADP
fnp-3806	368	29	ionotropic	ionotropic	ADJ
fnp-3806	368	30	l	l	ADJ
fnp-3806	368	31	-	-	ADJ
fnp-3806	368	32	glutamate	glutamate	ADJ
fnp-3806	368	33	receptors	receptor	NOUN
fnp-3806	368	34	might	might	AUX
fnp-3806	368	35	enhance	enhance	VERB
fnp-3806	368	36	vulnerability	vulnerability	NOUN
fnp-3806	368	37	of	of	ADP
fnp-3806	368	38	neurons	neuron	NOUN
fnp-3806	368	39	in	in	ADP
fnp-3806	368	40	ad	ad	NOUN
fnp-3806	368	41	(	(	PUNCT
fnp-3806	368	42	433	433	NUM
fnp-3806	368	43	,	,	PUNCT
fnp-3806	368	44	434	434	NUM
fnp-3806	368	45	)	)	PUNCT
fnp-3806	368	46	.	.	PUNCT
fnp-3806	369	1	the	the	DET
fnp-3806	369	2	role	role	NOUN
fnp-3806	369	3	of	of	ADP
fnp-3806	369	4	glutamate	glutamate	NOUN
fnp-3806	369	5	in	in	ADP
fnp-3806	369	6	the	the	DET
fnp-3806	369	7	pathogenesis	pathogenesis	NOUN
fnp-3806	369	8	of	of	ADP
fnp-3806	369	9	ad	ad	NOUN
fnp-3806	369	10	was	be	AUX
fnp-3806	369	11	driven	drive	VERB
fnp-3806	369	12	,	,	PUNCT
fnp-3806	369	13	in	in	ADP
fnp-3806	369	14	part	part	NOUN
fnp-3806	369	15	,	,	PUNCT
fnp-3806	369	16	by	by	ADP
fnp-3806	369	17	the	the	DET
fnp-3806	369	18	discovery	discovery	NOUN
fnp-3806	369	19	of	of	ADP
fnp-3806	369	20	altered	altered	ADJ
fnp-3806	369	21	glutamate	glutamate	NOUN
fnp-3806	369	22	transport	transport	NOUN
fnp-3806	369	23	and	and	CCONJ
fnp-3806	369	24	increased	increase	VERB
fnp-3806	369	25	excitotoxicity	excitotoxicity	NOUN
fnp-3806	369	26	in	in	ADP
fnp-3806	369	27	amyotrophic	amyotrophic	ADJ
fnp-3806	369	28	lateral	lateral	ADJ
fnp-3806	369	29	sclerosis	sclerosis	NOUN
fnp-3806	369	30	(	(	PUNCT
fnp-3806	369	31	435	435	NUM
fnp-3806	369	32	)	)	PUNCT
fnp-3806	369	33	,	,	PUNCT
fnp-3806	369	34	and	and	CCONJ
fnp-3806	369	35	the	the	DET
fnp-3806	369	36	interest	interest	NOUN
fnp-3806	369	37	at	at	ADP
fnp-3806	369	38	that	that	DET
fnp-3806	369	39	time	time	NOUN
fnp-3806	369	40	in	in	ADP
fnp-3806	369	41	excitatory	excitatory	ADJ
fnp-3806	369	42	amino	amino	NOUN
fnp-3806	369	43	acid	acid	NOUN
fnp-3806	369	44	neurotoxicity	neurotoxicity	NOUN
fnp-3806	369	45	in	in	ADP
fnp-3806	369	46	the	the	DET
fnp-3806	369	47	pathogenesis	pathogenesis	NOUN
fnp-3806	369	48	of	of	ADP
fnp-3806	369	49	neurodegenerative	neurodegenerative	ADJ
fnp-3806	369	50	diseases	disease	NOUN
fnp-3806	369	51	(	(	PUNCT
fnp-3806	369	52	436	436	NUM
fnp-3806	369	53	)	)	PUNCT
fnp-3806	369	54	.	.	PUNCT
fnp-3806	370	1	glutamate	glutamate	NOUN
fnp-3806	370	2	overload	overload	NOUN
fnp-3806	370	3	increases	increase	VERB
fnp-3806	370	4	mitochondrial	mitochondrial	ADJ
fnp-3806	370	5	ca2	ca2	PROPN
fnp-3806	370	6	+	+	X
fnp-3806	370	7	influx	influx	NOUN
fnp-3806	370	8	and	and	CCONJ
fnp-3806	370	9	oxidative	oxidative	ADJ
fnp-3806	370	10	stress	stress	NOUN
fnp-3806	370	11	and	and	CCONJ
fnp-3806	370	12	leads	lead	VERB
fnp-3806	370	13	to	to	ADP
fnp-3806	370	14	mitochondrial	mitochondrial	ADJ
fnp-3806	370	15	dysfunction	dysfunction	NOUN
fnp-3806	370	16	(	(	PUNCT
fnp-3806	370	17	437	437	NUM
fnp-3806	370	18	)	)	PUNCT
fnp-3806	370	19	.	.	PUNCT
fnp-3806	371	1	however	however	ADV
fnp-3806	371	2	,	,	PUNCT
fnp-3806	371	3	nmda	nmda	ADJ
fnp-3806	371	4	receptor	receptor	NOUN
fnp-3806	371	5	blockers	blocker	NOUN
fnp-3806	371	6	may	may	AUX
fnp-3806	371	7	also	also	ADV
fnp-3806	371	8	have	have	VERB
fnp-3806	371	9	undesirable	undesirable	ADJ
fnp-3806	371	10	effects	effect	NOUN
fnp-3806	371	11	due	due	ADP
fnp-3806	371	12	to	to	ADP
fnp-3806	371	13	their	their	PRON
fnp-3806	371	14	double	double	ADJ
fnp-3806	371	15	effects	effect	NOUN
fnp-3806	371	16	on	on	ADP
fnp-3806	371	17	cell	cell	NOUN
fnp-3806	371	18	death	death	NOUN
fnp-3806	371	19	as	as	ADV
fnp-3806	371	20	well	well	ADV
fnp-3806	371	21	as	as	ADP
fnp-3806	371	22	cell	cell	NOUN
fnp-3806	371	23	survival	survival	NOUN
fnp-3806	371	24	and	and	CCONJ
fnp-3806	371	25	plasticity	plasticity	NOUN
fnp-3806	371	26	(	(	PUNCT
fnp-3806	371	27	438	438	NUM
fnp-3806	371	28	)	)	PUNCT
fnp-3806	371	29	.	.	PUNCT
fnp-3806	372	1	now	now	ADV
fnp-3806	372	2	,	,	PUNCT
fnp-3806	372	3	neuroprotective	neuroprotective	ADJ
fnp-3806	372	4	therapies	therapy	NOUN
fnp-3806	372	5	aim	aim	VERB
fnp-3806	372	6	to	to	PART
fnp-3806	372	7	both	both	PRON
fnp-3806	372	8	enhance	enhance	VERB
fnp-3806	372	9	the	the	DET
fnp-3806	372	10	effect	effect	NOUN
fnp-3806	372	11	of	of	ADP
fnp-3806	372	12	synaptic	synaptic	ADJ
fnp-3806	372	13	activity	activity	NOUN
fnp-3806	372	14	and	and	CCONJ
fnp-3806	372	15	disrupt	disrupt	VERB
fnp-3806	372	16	extrasynaptic	extrasynaptic	ADJ
fnp-3806	372	17	nmdar	nmdar	ADJ
fnp-3806	372	18	-	-	PUNCT
fnp-3806	372	19	dependent	dependent	ADJ
fnp-3806	372	20	death	death	NOUN
fnp-3806	372	21	signaling	signal	VERB
fnp-3806	372	22	(	(	PUNCT
fnp-3806	372	23	438	438	NUM
fnp-3806	372	24	)	)	PUNCT
fnp-3806	372	25	.	.	PUNCT
fnp-3806	373	1	cholinergic	cholinergic	ADJ
fnp-3806	373	2	and	and	CCONJ
fnp-3806	373	3	glutamatergic	glutamatergic	ADJ
fnp-3806	373	4	neurotransmitter	neurotransmitter	NOUN
fnp-3806	373	5	alterations	alteration	NOUN
fnp-3806	373	6	play	play	VERB
fnp-3806	373	7	a	a	DET
fnp-3806	373	8	significant	significant	ADJ
fnp-3806	373	9	role	role	NOUN
fnp-3806	373	10	in	in	ADP
fnp-3806	373	11	the	the	DET
fnp-3806	373	12	pathogenesis	pathogenesis	NOUN
fnp-3806	373	13	of	of	ADP
fnp-3806	373	14	brain	brain	NOUN
fnp-3806	373	15	aging	aging	NOUN
fnp-3806	373	16	and	and	CCONJ
fnp-3806	373	17	sad	sad	ADJ
fnp-3806	373	18	(	(	PUNCT
fnp-3806	373	19	439	439	NUM
fnp-3806	373	20	-	-	SYM
fnp-3806	373	21	442	442	NUM
fnp-3806	373	22	)	)	PUNCT
fnp-3806	373	23	.	.	PUNCT
fnp-3806	374	1	other	other	ADJ
fnp-3806	374	2	neurotransmitters	neurotransmitter	NOUN
fnp-3806	374	3	and	and	CCONJ
fnp-3806	374	4	receptors	receptor	NOUN
fnp-3806	374	5	are	be	AUX
fnp-3806	374	6	involved	involve	VERB
fnp-3806	374	7	as	as	ADV
fnp-3806	374	8	well	well	ADV
fnp-3806	374	9	.	.	PUNCT
fnp-3806	375	1	the	the	DET
fnp-3806	375	2	important	important	ADJ
fnp-3806	375	3	point	point	NOUN
fnp-3806	375	4	is	be	AUX
fnp-3806	375	5	that	that	SCONJ
fnp-3806	375	6	alterations	alteration	NOUN
fnp-3806	375	7	are	be	AUX
fnp-3806	375	8	not	not	PART
fnp-3806	375	9	homogeneous	homogeneous	ADJ
fnp-3806	375	10	;	;	PUNCT
fnp-3806	375	11	they	they	PRON
fnp-3806	375	12	depend	depend	VERB
fnp-3806	375	13	on	on	ADP
fnp-3806	375	14	the	the	DET
fnp-3806	375	15	type	type	NOUN
fnp-3806	375	16	of	of	ADP
fnp-3806	375	17	neurotransmitter	neurotransmitter	NOUN
fnp-3806	375	18	,	,	PUNCT
fnp-3806	375	19	the	the	DET
fnp-3806	375	20	cells	cell	NOUN
fnp-3806	375	21	of	of	ADP
fnp-3806	375	22	origin	origin	NOUN
fnp-3806	375	23	,	,	PUNCT
fnp-3806	375	24	and	and	CCONJ
fnp-3806	375	25	the	the	DET
fnp-3806	375	26	kind	kind	NOUN
fnp-3806	375	27	of	of	ADP
fnp-3806	375	28	receptor	receptor	NOUN
fnp-3806	375	29	;	;	PUNCT
fnp-3806	375	30	not	not	PART
fnp-3806	375	31	all	all	DET
fnp-3806	375	32	receptors	receptor	NOUN
fnp-3806	375	33	of	of	ADP
fnp-3806	375	34	a	a	DET
fnp-3806	375	35	given	give	VERB
fnp-3806	375	36	neurotransmitter	neurotransmitter	NOUN
fnp-3806	375	37	are	be	AUX
fnp-3806	375	38	equally	equally	ADV
fnp-3806	375	39	vulnerable	vulnerable	ADJ
fnp-3806	375	40	to	to	ADP
fnp-3806	375	41	aging	aging	NOUN
fnp-3806	375	42	and	and	CCONJ
fnp-3806	375	43	sad	sad	ADJ
fnp-3806	375	44	.	.	PUNCT
fnp-3806	376	1	in	in	ADP
fnp-3806	376	2	addition	addition	NOUN
fnp-3806	376	3	to	to	ADP
fnp-3806	376	4	the	the	DET
fnp-3806	376	5	neurotransmitters	neurotransmitter	NOUN
fnp-3806	376	6	,	,	PUNCT
fnp-3806	376	7	neuromodulators	neuromodulator	NOUN
fnp-3806	376	8	,	,	PUNCT
fnp-3806	376	9	and	and	CCONJ
fnp-3806	376	10	receptors	receptor	NOUN
fnp-3806	376	11	discussed	discuss	VERB
fnp-3806	376	12	below	below	ADV
fnp-3806	376	13	,	,	PUNCT
fnp-3806	376	14	general	general	ADJ
fnp-3806	376	15	aspects	aspect	NOUN
fnp-3806	376	16	of	of	ADP
fnp-3806	376	17	gpcr	gpcr	ADJ
fnp-3806	376	18	,	,	PUNCT
fnp-3806	376	19	amylin	amylin	NOUN
fnp-3806	376	20	receptors	receptor	NOUN
fnp-3806	376	21	,	,	PUNCT
fnp-3806	376	22	netrin	netrin	NOUN
fnp-3806	376	23	receptors	receptor	NOUN
fnp-3806	376	24	,	,	PUNCT
fnp-3806	376	25	and	and	CCONJ
fnp-3806	376	26	dopamine	dopamine	NOUN
fnp-3806	376	27	receptors	receptor	NOUN
fnp-3806	376	28	in	in	ADP
fnp-3806	376	29	sad	sad	ADJ
fnp-3806	376	30	are	be	AUX
fnp-3806	376	31	detailed	detail	VERB
fnp-3806	376	32	in	in	ADP
fnp-3806	376	33	other	other	ADJ
fnp-3806	376	34	reviews	review	NOUN
fnp-3806	376	35	(	(	PUNCT
fnp-3806	376	36	443	443	NUM
fnp-3806	376	37	,	,	PUNCT
fnp-3806	376	38	444	444	NUM
fnp-3806	376	39	)	)	PUNCT
fnp-3806	376	40	.	.	PUNCT
fnp-3806	377	1	endorphins	endorphin	NOUN
fnp-3806	377	2	,	,	PUNCT
fnp-3806	377	3	enkephalins	enkephalin	NOUN
fnp-3806	377	4	,	,	PUNCT
fnp-3806	377	5	dynorphins	dynorphin	NOUN
fnp-3806	377	6	,	,	PUNCT
fnp-3806	377	7	and	and	CCONJ
fnp-3806	377	8	endomorphins	endomorphin	NOUN
fnp-3806	377	9	are	be	AUX
fnp-3806	377	10	endogenous	endogenous	ADJ
fnp-3806	377	11	opioid	opioid	ADJ
fnp-3806	377	12	peptides	peptide	NOUN
fnp-3806	377	13	that	that	PRON
fnp-3806	377	14	bind	bind	VERB
fnp-3806	377	15	to	to	ADP
fnp-3806	377	16	opioid	opioid	ADJ
fnp-3806	377	17	receptors	receptor	NOUN
fnp-3806	377	18	.	.	PUNCT
fnp-3806	378	1	β	β	X
fnp-3806	378	2	-	-	PUNCT
fnp-3806	378	3	endorphin	endorphin	NOUN
fnp-3806	378	4	has	have	VERB
fnp-3806	378	5	opioid	opioid	ADJ
fnp-3806	378	6	activity	activity	NOUN
fnp-3806	378	7	through	through	ADP
fnp-3806	378	8	μ	μ	NOUN
fnp-3806	378	9	-	-	NOUN
fnp-3806	378	10	receptors	receptor	NOUN
fnp-3806	378	11	,	,	PUNCT
fnp-3806	378	12	but	but	CCONJ
fnp-3806	378	13	α	α	X
fnp-3806	378	14	-	-	PUNCT
fnp-3806	378	15	endorphin	endorphin	NOUN
fnp-3806	378	16	and	and	CCONJ
fnp-3806	378	17	γ	γ	NOUN
fnp-3806	378	18	-	-	PUNCT
fnp-3806	378	19	endorphin	endorphin	NOUN
fnp-3806	378	20	lack	lack	NOUN
fnp-3806	378	21	affinity	affinity	NOUN
fnp-3806	378	22	for	for	ADP
fnp-3806	378	23	opiate	opiate	ADJ
fnp-3806	378	24	receptors	receptor	NOUN
fnp-3806	378	25	.	.	PUNCT
fnp-3806	379	1	endorphins	endorphin	NOUN
fnp-3806	379	2	interact	interact	VERB
fnp-3806	379	3	with	with	ADP
fnp-3806	379	4	the	the	DET
fnp-3806	379	5	γaminobutyric	γaminobutyric	ADJ
fnp-3806	379	6	acid	acid	PROPN
fnp-3806	379	7	(	(	PUNCT
fnp-3806	379	8	gaba	gaba	PROPN
fnp-3806	379	9	)	)	PUNCT
fnp-3806	379	10	,	,	PUNCT
fnp-3806	379	11	which	which	PRON
fnp-3806	379	12	in	in	ADP
fnp-3806	379	13	turn	turn	NOUN
fnp-3806	379	14	modulates	modulate	VERB
fnp-3806	379	15	the	the	DET
fnp-3806	379	16	release	release	NOUN
fnp-3806	379	17	of	of	ADP
fnp-3806	379	18	dopamine	dopamine	NOUN
fnp-3806	379	19	.	.	PUNCT
fnp-3806	380	1	the	the	DET
fnp-3806	380	2	expression	expression	NOUN
fnp-3806	380	3	of	of	ADP
fnp-3806	380	4	endogenous	endogenous	ADJ
fnp-3806	380	5	opioids	opioid	NOUN
fnp-3806	380	6	and	and	CCONJ
fnp-3806	380	7	receptors	receptor	NOUN
fnp-3806	380	8	is	be	AUX
fnp-3806	380	9	altered	alter	VERB
fnp-3806	380	10	in	in	ADP
fnp-3806	380	11	human	human	ADJ
fnp-3806	380	12	brain	brain	NOUN
fnp-3806	380	13	aging	aging	NOUN
fnp-3806	380	14	and	and	CCONJ
fnp-3806	380	15	sad	sad	ADJ
fnp-3806	380	16	(	(	PUNCT
fnp-3806	380	17	445	445	NUM
fnp-3806	380	18	-	-	SYM
fnp-3806	380	19	448	448	NUM
fnp-3806	380	20	)	)	PUNCT
fnp-3806	380	21	.	.	PUNCT
fnp-3806	381	1	many	many	ADJ
fnp-3806	381	2	olfactory	olfactory	NOUN
fnp-3806	381	3	and	and	CCONJ
fnp-3806	381	4	taste	taste	NOUN
fnp-3806	381	5	receptors	receptor	NOUN
fnp-3806	381	6	and	and	CCONJ
fnp-3806	381	7	molecules	molecule	NOUN
fnp-3806	381	8	involved	involve	VERB
fnp-3806	381	9	downstream	downstream	ADV
fnp-3806	381	10	are	be	AUX
fnp-3806	381	11	expressed	express	VERB
fnp-3806	381	12	in	in	ADP
fnp-3806	381	13	the	the	DET
fnp-3806	381	14	human	human	ADJ
fnp-3806	381	15	brain	brain	NOUN
fnp-3806	381	16	(	(	PUNCT
fnp-3806	381	17	449	449	NUM
fnp-3806	381	18	)	)	PUNCT
fnp-3806	381	19	.	.	PUNCT
fnp-3806	382	1	their	their	PRON
fnp-3806	382	2	ligands	ligand	NOUN
fnp-3806	382	3	and	and	CCONJ
fnp-3806	382	4	functions	function	NOUN
fnp-3806	382	5	remain	remain	VERB
fnp-3806	382	6	unknown	unknown	ADJ
fnp-3806	382	7	,	,	PUNCT
fnp-3806	382	8	although	although	SCONJ
fnp-3806	382	9	both	both	PRON
fnp-3806	382	10	olfactory	olfactory	ADJ
fnp-3806	382	11	and	and	CCONJ
fnp-3806	382	12	taste	taste	NOUN
fnp-3806	382	13	receptors	receptor	NOUN
fnp-3806	382	14	might	might	AUX
fnp-3806	382	15	contribute	contribute	VERB
fnp-3806	382	16	to	to	ADP
fnp-3806	382	17	intercellular	intercellular	ADJ
fnp-3806	382	18	and	and	CCONJ
fnp-3806	382	19	intracellular	intracellular	ADJ
fnp-3806	382	20	cell	cell	NOUN
fnp-3806	382	21	signaling	signal	VERB
fnp-3806	382	22	.	.	PUNCT
fnp-3806	383	1	the	the	DET
fnp-3806	383	2	expression	expression	NOUN
fnp-3806	383	3	of	of	ADP
fnp-3806	383	4	some	some	DET
fnp-3806	383	5	olfactory	olfactory	ADJ
fnp-3806	383	6	receptors	receptor	NOUN
fnp-3806	383	7	is	be	AUX
fnp-3806	383	8	altered	alter	VERB
fnp-3806	383	9	in	in	ADP
fnp-3806	383	10	sad	sad	ADJ
fnp-3806	383	11	and	and	CCONJ
fnp-3806	383	12	other	other	ADJ
fnp-3806	383	13	neurodegenerative	neurodegenerative	ADJ
fnp-3806	383	14	diseases	disease	NOUN
fnp-3806	383	15	(	(	PUNCT
fnp-3806	383	16	450	450	NUM
fnp-3806	383	17	)	)	PUNCT
fnp-3806	383	18	.	.	PUNCT
fnp-3806	384	1	7a	7a	NUM
fnp-3806	384	2	.	.	PUNCT
fnp-3806	385	1	acetylcholine	acetylcholine	NOUN
fnp-3806	385	2	(	(	PUNCT
fnp-3806	385	3	ach	ach	PROPN
fnp-3806	385	4	)	)	PUNCT
fnp-3806	385	5	and	and	CCONJ
fnp-3806	385	6	acetylcholine	acetylcholine	NOUN
fnp-3806	385	7	receptors	receptor	NOUN
fnp-3806	385	8	(	(	PUNCT
fnp-3806	385	9	achr	achr	NOUN
fnp-3806	385	10	)	)	PUNCT
fnp-3806	386	1	ach	ach	PROPN
fnp-3806	386	2	is	be	AUX
fnp-3806	386	3	synthesized	synthesize	VERB
fnp-3806	386	4	in	in	ADP
fnp-3806	386	5	neurons	neuron	NOUN
fnp-3806	386	6	by	by	ADP
fnp-3806	386	7	choline	choline	NOUN
fnp-3806	386	8	acetyl	acetyl	NOUN
fnp-3806	386	9	transferase	transferase	NOUN
fnp-3806	386	10	(	(	PUNCT
fnp-3806	386	11	chat	chat	PROPN
fnp-3806	386	12	)	)	PUNCT
fnp-3806	386	13	.	.	PUNCT
fnp-3806	387	1	ach	ach	PROPN
fnp-3806	387	2	acts	act	VERB
fnp-3806	387	3	upon	upon	SCONJ
fnp-3806	387	4	nicotinic	nicotinic	ADJ
fnp-3806	387	5	acetylcholine	acetylcholine	NOUN
fnp-3806	387	6	receptors	receptor	NOUN
fnp-3806	387	7	(	(	PUNCT
fnp-3806	387	8	nachrs	nachrs	ADV
fnp-3806	387	9	)	)	PUNCT
fnp-3806	387	10	and	and	CCONJ
fnp-3806	387	11	muscarinic	muscarinic	ADJ
fnp-3806	387	12	acetylcholine	acetylcholine	NOUN
fnp-3806	387	13	receptors	receptor	NOUN
fnp-3806	387	14	(	(	PUNCT
fnp-3806	387	15	machrs	machrs	ADJ
fnp-3806	387	16	)	)	PUNCT
fnp-3806	387	17	.	.	PUNCT
fnp-3806	388	1	ach	ach	PROPN
fnp-3806	388	2	is	be	AUX
fnp-3806	388	3	degraded	degrade	VERB
fnp-3806	388	4	by	by	ADP
fnp-3806	388	5	acetylcholinesterase	acetylcholinesterase	NOUN
fnp-3806	388	6	(	(	PUNCT
fnp-3806	388	7	ache	ache	ADV
fnp-3806	388	8	)	)	PUNCT
fnp-3806	388	9	.	.	PUNCT
fnp-3806	389	1	nicotinic	nicotinic	ADJ
fnp-3806	389	2	receptors	receptor	NOUN
fnp-3806	389	3	are	be	AUX
fnp-3806	389	4	ionotropic	ionotropic	ADJ
fnp-3806	389	5	ligand	ligand	NOUN
fnp-3806	389	6	-	-	PUNCT
fnp-3806	389	7	gated	gate	VERB
fnp-3806	389	8	receptors	receptor	NOUN
fnp-3806	389	9	,	,	PUNCT
fnp-3806	389	10	and	and	CCONJ
fnp-3806	389	11	muscarinic	muscarinic	ADJ
fnp-3806	389	12	receptors	receptor	NOUN
fnp-3806	389	13	are	be	AUX
fnp-3806	389	14	gpcr	gpcr	ADJ
fnp-3806	389	15	(	(	PUNCT
fnp-3806	389	16	451	451	NUM
fnp-3806	389	17	)	)	PUNCT
fnp-3806	389	18	.	.	PUNCT
fnp-3806	390	1	the	the	DET
fnp-3806	390	2	nachrs	nachrs	ADJ
fnp-3806	390	3	are	be	AUX
fnp-3806	390	4	arranged	arrange	VERB
fnp-3806	390	5	into	into	ADP
fnp-3806	390	6	homomeric	homomeric	ADJ
fnp-3806	390	7	or	or	CCONJ
fnp-3806	390	8	heteromeric	heteromeric	ADJ
fnp-3806	390	9	subunits	subunit	NOUN
fnp-3806	390	10	consisting	consist	VERB
fnp-3806	390	11	of	of	ADP
fnp-3806	390	12	a	a	DET
fnp-3806	390	13	diverse	diverse	ADJ
fnp-3806	390	14	set	set	NOUN
fnp-3806	390	15	of	of	ADP
fnp-3806	390	16	complex	complex	ADJ
fnp-3806	390	17	subtypes	subtype	NOUN
fnp-3806	390	18	including	include	VERB
fnp-3806	390	19	α1	α1	PROPN
fnp-3806	390	20	-	-	SYM
fnp-3806	390	21	7	7	NUM
fnp-3806	390	22	,	,	PUNCT
fnp-3806	390	23	α9	α9	PROPN
fnp-3806	390	24	-	-	NOUN
fnp-3806	390	25	10	10	NUM
fnp-3806	390	26	,	,	PUNCT
fnp-3806	390	27	β14	β14	NOUN
fnp-3806	390	28	,	,	PUNCT
fnp-3806	390	29	γ	γ	PROPN
fnp-3806	390	30	,	,	PUNCT
fnp-3806	390	31	δ	δ	PROPN
fnp-3806	390	32	,	,	PUNCT
fnp-3806	390	33	and	and	CCONJ
fnp-3806	390	34	ε	ε	PROPN
fnp-3806	390	35	.	.	PUNCT
fnp-3806	390	36	allosteric	allosteric	ADJ
fnp-3806	390	37	modulation	modulation	NOUN
fnp-3806	390	38	of	of	ADP
fnp-3806	390	39	nachrs	nachrs	ADJ
fnp-3806	390	40	increases	increase	NOUN
fnp-3806	390	41	pre	pre	ADJ
fnp-3806	390	42	-	-	ADJ
fnp-3806	390	43	synaptic	synaptic	ADJ
fnp-3806	390	44	ach	ach	NOUN
fnp-3806	390	45	levels	level	NOUN
fnp-3806	390	46	and	and	CCONJ
fnp-3806	390	47	enhances	enhance	VERB
fnp-3806	390	48	the	the	DET
fnp-3806	390	49	cholinergic	cholinergic	ADJ
fnp-3806	390	50	nicotinic	nicotinic	ADJ
fnp-3806	390	51	neurotransmission	neurotransmission	NOUN
fnp-3806	390	52	.	.	PUNCT
fnp-3806	391	1	α7	α7	NOUN
fnp-3806	391	2	and	and	CCONJ
fnp-3806	391	3	α4β2	α4β2	X
fnp-3806	391	4	nachr	nachr	PROPN
fnp-3806	391	5	mediate	mediate	VERB
fnp-3806	391	6	the	the	DET
fnp-3806	391	7	presynaptic	presynaptic	ADJ
fnp-3806	391	8	release	release	NOUN
fnp-3806	391	9	of	of	ADP
fnp-3806	391	10	ach	ach	PROPN
fnp-3806	391	11	.	.	PROPN
fnp-3806	392	1	nachrs	nachrs	PROPN
fnp-3806	392	2	are	be	AUX
fnp-3806	392	3	also	also	ADV
fnp-3806	392	4	expressed	express	VERB
fnp-3806	392	5	in	in	ADP
fnp-3806	392	6	astrocytes	astrocyte	NOUN
fnp-3806	392	7	and	and	CCONJ
fnp-3806	392	8	microglia	microglia	ADJ
fnp-3806	392	9	(	(	PUNCT
fnp-3806	392	10	452	452	NUM
fnp-3806	392	11	,	,	PUNCT
fnp-3806	392	12	453	453	NUM
fnp-3806	392	13	)	)	PUNCT
fnp-3806	392	14	.	.	PUNCT
fnp-3806	393	1	through	through	ADP
fnp-3806	393	2	its	its	PRON
fnp-3806	393	3	receptors	receptor	NOUN
fnp-3806	393	4	trka	trka	ADJ
fnp-3806	393	5	and	and	CCONJ
fnp-3806	393	6	p75ntr	p75ntr	NOUN
fnp-3806	393	7	,	,	PUNCT
fnp-3806	393	8	the	the	DET
fnp-3806	393	9	nerve	nerve	NOUN
fnp-3806	393	10	growth	growth	NOUN
fnp-3806	393	11	factor	factor	NOUN
fnp-3806	393	12	(	(	PUNCT
fnp-3806	393	13	ngf	ngf	ADV
fnp-3806	393	14	)	)	PUNCT
fnp-3806	393	15	plays	play	VERB
fnp-3806	393	16	an	an	DET
fnp-3806	393	17	essential	essential	ADJ
fnp-3806	393	18	role	role	NOUN
fnp-3806	393	19	in	in	ADP
fnp-3806	393	20	the	the	DET
fnp-3806	393	21	survival	survival	NOUN
fnp-3806	393	22	and	and	CCONJ
fnp-3806	393	23	maintenance	maintenance	NOUN
fnp-3806	393	24	of	of	ADP
fnp-3806	393	25	cholinergic	cholinergic	ADJ
fnp-3806	393	26	neurons	neuron	NOUN
fnp-3806	393	27	in	in	ADP
fnp-3806	393	28	the	the	DET
fnp-3806	393	29	basal	basal	ADJ
fnp-3806	393	30	forebrain	forebrain	NOUN
fnp-3806	393	31	(	(	PUNCT
fnp-3806	393	32	454	454	NUM
fnp-3806	393	33	-	-	NUM
fnp-3806	393	34	457	457	NUM
fnp-3806	393	35	)	)	PUNCT
fnp-3806	393	36	.	.	PUNCT
fnp-3806	394	1	loss	loss	NOUN
fnp-3806	394	2	of	of	ADP
fnp-3806	394	3	basal	basal	ADJ
fnp-3806	394	4	forebrain	forebrain	NOUN
fnp-3806	394	5	cholinergic	cholinergic	ADJ
fnp-3806	394	6	neurons	neuron	NOUN
fnp-3806	394	7	occurs	occur	VERB
fnp-3806	394	8	at	at	ADP
fnp-3806	394	9	early	early	ADJ
fnp-3806	394	10	stages	stage	NOUN
fnp-3806	394	11	of	of	ADP
fnp-3806	394	12	nft	nft	PROPN
fnp-3806	394	13	pathology	pathology	PROPN
fnp-3806	394	14	(	(	PUNCT
fnp-3806	394	15	428	428	NUM
fnp-3806	394	16	,	,	PUNCT
fnp-3806	394	17	458	458	NUM
fnp-3806	394	18	,	,	PUNCT
fnp-3806	394	19	459	459	NUM
fnp-3806	394	20	)	)	PUNCT
fnp-3806	394	21	.	.	PUNCT
fnp-3806	395	1	pretangle	pretangle	VERB
fnp-3806	395	2	pathology	pathology	NOUN
fnp-3806	395	3	within	within	ADP
fnp-3806	395	4	cholinergic	cholinergic	ADJ
fnp-3806	395	5	nucleus	nucleus	NOUN
fnp-3806	395	6	basalis	basalis	PROPN
fnp-3806	395	7	neurons	neuron	NOUN
fnp-3806	395	8	coincides	coincide	VERB
fnp-3806	395	9	with	with	ADP
fnp-3806	395	10	local	local	ADJ
fnp-3806	395	11	neurotrophic	neurotrophic	ADJ
fnp-3806	395	12	and	and	CCONJ
fnp-3806	395	13	neurotransmitter	neurotransmitter	NOUN
fnp-3806	395	14	receptor	receptor	NOUN
fnp-3806	395	15	gene	gene	NOUN
fnp-3806	395	16	dysregulation	dysregulation	NOUN
fnp-3806	395	17	(	(	PUNCT
fnp-3806	395	18	460	460	NUM
fnp-3806	395	19	)	)	PUNCT
fnp-3806	395	20	.	.	PUNCT
fnp-3806	396	1	loss	loss	NOUN
fnp-3806	396	2	of	of	ADP
fnp-3806	396	3	cholinergic	cholinergic	ADJ
fnp-3806	396	4	neurons	neuron	NOUN
fnp-3806	396	5	in	in	ADP
fnp-3806	396	6	the	the	DET
fnp-3806	396	7	basal	basal	ADJ
fnp-3806	396	8	forebrain	forebrain	NOUN
fnp-3806	396	9	leads	lead	VERB
fnp-3806	396	10	to	to	ADP
fnp-3806	396	11	reduced	reduce	VERB
fnp-3806	396	12	ach	ach	PROPN
fnp-3806	396	13	levels	level	NOUN
fnp-3806	396	14	and	and	CCONJ
fnp-3806	396	15	chat	chat	VERB
fnp-3806	396	16	upregulation	upregulation	NOUN
fnp-3806	396	17	(	(	PUNCT
fnp-3806	396	18	461	461	NUM
fnp-3806	396	19	)	)	PUNCT
fnp-3806	396	20	.	.	PUNCT
fnp-3806	397	1	in	in	ADP
fnp-3806	397	2	addition	addition	NOUN
fnp-3806	397	3	,	,	PUNCT
fnp-3806	397	4	nachrs	nachrs	ADV
fnp-3806	397	5	,	,	PUNCT
fnp-3806	397	6	particularly	particularly	ADV
fnp-3806	397	7	α7nachrs	α7nachrs	NUM
fnp-3806	397	8	,	,	PUNCT
fnp-3806	397	9	are	be	AUX
fnp-3806	397	10	altered	alter	VERB
fnp-3806	397	11	in	in	ADP
fnp-3806	397	12	sad	sad	ADJ
fnp-3806	397	13	(	(	PUNCT
fnp-3806	397	14	462	462	NUM
fnp-3806	397	15	-	-	NUM
fnp-3806	397	16	465	465	NUM
fnp-3806	397	17	)	)	PUNCT
fnp-3806	397	18	.	.	PUNCT
fnp-3806	398	1	importantly	importantly	ADV
fnp-3806	398	2	,	,	PUNCT
fnp-3806	398	3	nicotine	nicotine	ADJ
fnp-3806	398	4	and	and	CCONJ
fnp-3806	398	5	nachrs	nachrs	ADV
fnp-3806	398	6	also	also	ADV
fnp-3806	398	7	participate	participate	VERB
fnp-3806	398	8	in	in	ADP
fnp-3806	398	9	the	the	DET
fnp-3806	398	10	regulation	regulation	NOUN
fnp-3806	398	11	of	of	ADP
fnp-3806	398	12	aβ	aβ	NOUN
fnp-3806	398	13	.	.	PUNCT
fnp-3806	399	1	on	on	ADP
fnp-3806	399	2	the	the	DET
fnp-3806	399	3	one	one	NUM
fnp-3806	399	4	hand	hand	NOUN
fnp-3806	399	5	,	,	PUNCT
fnp-3806	399	6	nicotine	nicotine	NOUN
fnp-3806	399	7	inhibits	inhibit	VERB
fnp-3806	399	8	the	the	DET
fnp-3806	399	9	formation	formation	NOUN
fnp-3806	399	10	of	of	ADP
fnp-3806	399	11	aβ1	aβ1	NOUN
fnp-3806	399	12	-	-	PUNCT
fnp-3806	399	13	42	42	NUM
fnp-3806	399	14	fibrils	fibril	NOUN
fnp-3806	399	15	and	and	CCONJ
fnp-3806	399	16	disrupts	disrupts	AUX
fnp-3806	399	17	preformed	preform	VERB
fnp-3806	399	18	aβ	aβ	NOUN
fnp-3806	399	19	fibrils	fibril	NOUN
fnp-3806	399	20	(	(	PUNCT
fnp-3806	399	21	466	466	NUM
fnp-3806	399	22	)	)	PUNCT
fnp-3806	399	23	.	.	PUNCT
fnp-3806	400	1	on	on	ADP
fnp-3806	400	2	the	the	DET
fnp-3806	400	3	other	other	ADJ
fnp-3806	400	4	hand	hand	NOUN
fnp-3806	400	5	,	,	PUNCT
fnp-3806	400	6	aβ1	aβ1	NOUN
fnp-3806	400	7	-	-	PUNCT
fnp-3806	400	8	42	42	NUM
fnp-3806	400	9	binds	bind	VERB
fnp-3806	400	10	to	to	ADP
fnp-3806	400	11	α7nachr	α7nachr	NOUN
fnp-3806	400	12	and	and	CCONJ
fnp-3806	400	13	inhibits	inhibit	VERB
fnp-3806	400	14	the	the	DET
fnp-3806	400	15	release	release	NOUN
fnp-3806	400	16	of	of	ADP
fnp-3806	400	17	ach	ach	PROPN
fnp-3806	400	18	(	(	PUNCT
fnp-3806	400	19	467	467	NUM
fnp-3806	400	20	)	)	PUNCT
fnp-3806	400	21	.	.	PUNCT
fnp-3806	401	1	finally	finally	ADV
fnp-3806	401	2	,	,	PUNCT
fnp-3806	401	3	α7	α7	PROPN
fnp-3806	401	4	nachrs	nachrs	NOUN
fnp-3806	401	5	mediate	mediate	VERB
fnp-3806	401	6	aβ	aβ	ADV
fnp-3806	401	7	-	-	PUNCT
fnp-3806	401	8	induced	induce	VERB
fnp-3806	401	9	neurotoxicity	neurotoxicity	NOUN
fnp-3806	401	10	(	(	PUNCT
fnp-3806	401	11	468	468	NUM
fnp-3806	401	12	,	,	PUNCT
fnp-3806	401	13	469	469	NUM
fnp-3806	401	14	)	)	PUNCT
fnp-3806	401	15	.	.	PUNCT
fnp-3806	402	1	and	and	CCONJ
fnp-3806	402	2	aβ	aβ	ADV
fnp-3806	402	3	-	-	PUNCT
fnp-3806	402	4	induced	induced	ADJ
fnp-3806	402	5	tau	tau	PROPN
fnp-3806	402	6	phosphorylation	phosphorylation	NOUN
fnp-3806	402	7	(	(	PUNCT
fnp-3806	402	8	470	470	NUM
fnp-3806	402	9	)	)	PUNCT
fnp-3806	402	10	.	.	PUNCT
fnp-3806	403	1	α7nachrs	α7nachrs	PROPN
fnp-3806	403	2	also	also	ADV
fnp-3806	403	3	participate	participate	VERB
fnp-3806	403	4	in	in	ADP
fnp-3806	403	5	microglial	microglial	ADJ
fnp-3806	403	6	activation	activation	NOUN
fnp-3806	403	7	(	(	PUNCT
fnp-3806	403	8	471	471	NUM
fnp-3806	403	9	)	)	PUNCT
fnp-3806	403	10	.	.	PUNCT
fnp-3806	404	1	astrocytic	astrocytic	ADJ
fnp-3806	404	2	and	and	CCONJ
fnp-3806	404	3	microglial	microglial	ADJ
fnp-3806	404	4	nachrs	nachrs	ADV
fnp-3806	404	5	modulate	modulate	VERB
fnp-3806	404	6	aβ	aβ	NOUN
fnp-3806	404	7	phagocytosis	phagocytosis	NOUN
fnp-3806	404	8	and	and	CCONJ
fnp-3806	404	9	degradation	degradation	NOUN
fnp-3806	404	10	,	,	PUNCT
fnp-3806	404	11	aβ	aβ	NOUN
fnp-3806	404	12	-	-	PUNCT
fnp-3806	404	13	related	relate	VERB
fnp-3806	404	14	oxidative	oxidative	ADJ
fnp-3806	404	15	stress	stress	NOUN
fnp-3806	404	16	,	,	PUNCT
fnp-3806	404	17	and	and	CCONJ
fnp-3806	404	18	neurotoxicity	neurotoxicity	NOUN
fnp-3806	404	19	(	(	PUNCT
fnp-3806	404	20	472	472	NUM
fnp-3806	404	21	)	)	PUNCT
fnp-3806	404	22	.	.	PUNCT
fnp-3806	405	1	the	the	DET
fnp-3806	405	2	metabotropic	metabotropic	NOUN
fnp-3806	405	3	machrs	machrs	NOUN
fnp-3806	405	4	are	be	AUX
fnp-3806	405	5	classified	classify	VERB
fnp-3806	405	6	into	into	ADP
fnp-3806	405	7	five	five	NUM
fnp-3806	405	8	m1	m1	NOUN
fnp-3806	405	9	-	-	PUNCT
fnp-3806	405	10	m5	m5	ADJ
fnp-3806	405	11	subtypes	subtype	NOUN
fnp-3806	405	12	(	(	PUNCT
fnp-3806	405	13	473	473	NUM
fnp-3806	405	14	)	)	PUNCT
fnp-3806	405	15	.	.	PUNCT
fnp-3806	406	1	m1	m1	PROPN
fnp-3806	406	2	,	,	PUNCT
fnp-3806	406	3	m3	m3	PROPN
fnp-3806	406	4	,	,	PUNCT
fnp-3806	406	5	and	and	CCONJ
fnp-3806	406	6	m5	m5	NOUN
fnp-3806	406	7	receptors	receptor	NOUN
fnp-3806	406	8	interact	interact	VERB
fnp-3806	406	9	with	with	ADP
fnp-3806	406	10	the	the	DET
fnp-3806	406	11	gq/11	gq/11	PROPN
fnp-3806	406	12	protein	protein	NOUN
fnp-3806	406	13	,	,	PUNCT
fnp-3806	406	14	stimulate	stimulate	VERB
fnp-3806	406	15	phospholipase	phospholipase	NOUN
fnp-3806	406	16	c	c	PROPN
fnp-3806	406	17	(	(	PUNCT
fnp-3806	406	18	plc	plc	PROPN
fnp-3806	406	19	)	)	PUNCT
fnp-3806	406	20	,	,	PUNCT
fnp-3806	406	21	phosphatidylinositol	phosphatidylinositol	NOUN
fnp-3806	406	22	trisphosphate	trisphosphate	NOUN
fnp-3806	406	23	(	(	PUNCT
fnp-3806	406	24	pi3p	pi3p	NOUN
fnp-3806	406	25	)	)	PUNCT
fnp-3806	406	26	,	,	PUNCT
fnp-3806	406	27	and	and	CCONJ
fnp-3806	406	28	activate	activate	VERB
fnp-3806	406	29	protein	protein	NOUN
fnp-3806	406	30	kinase	kinase	PROPN
fnp-3806	406	31	c	c	PROPN
fnp-3806	406	32	(	(	PUNCT
fnp-3806	406	33	pkc	pkc	PROPN
fnp-3806	406	34	)	)	PUNCT
fnp-3806	406	35	.	.	PUNCT
fnp-3806	407	1	m2	m2	PROPN
fnp-3806	407	2	and	and	CCONJ
fnp-3806	407	3	m4	m4	PROPN
fnp-3806	407	4	receptors	receptor	NOUN
fnp-3806	407	5	interact	interact	VERB
fnp-3806	407	6	with	with	AUX
fnp-3806	407	7	go	go	VERB
fnp-3806	407	8	/	/	SYM
fnp-3806	408	1	i	i	PRON
fnp-3806	408	2	proteins	protein	NOUN
fnp-3806	408	3	,	,	PUNCT
fnp-3806	408	4	inhibit	inhibit	NOUN
fnp-3806	408	5	adenylyl	adenylyl	NOUN
fnp-3806	408	6	cyclase	cyclase	NOUN
fnp-3806	408	7	(	(	PUNCT
fnp-3806	408	8	ac	ac	PROPN
fnp-3806	408	9	)	)	PUNCT
fnp-3806	408	10	and	and	CCONJ
fnp-3806	408	11	protein	protein	NOUN
fnp-3806	408	12	kinase	kinase	PROPN
fnp-3806	408	13	a	a	DET
fnp-3806	408	14	(	(	PUNCT
fnp-3806	408	15	pka	pka	NOUN
fnp-3806	408	16	)	)	PUNCT
fnp-3806	408	17	,	,	PUNCT
fnp-3806	408	18	and	and	CCONJ
fnp-3806	408	19	decrease	decrease	VERB
fnp-3806	408	20	camp	camp	NOUN
fnp-3806	408	21	levels	level	NOUN
fnp-3806	408	22	(	(	PUNCT
fnp-3806	408	23	474	474	NUM
fnp-3806	408	24	-	-	NOUN
fnp-3806	408	25	476	476	NUM
fnp-3806	408	26	)	)	PUNCT
fnp-3806	408	27	.	.	PUNCT
fnp-3806	409	1	there	there	PRON
fnp-3806	409	2	are	be	VERB
fnp-3806	409	3	no	no	DET
fnp-3806	409	4	changes	change	NOUN
fnp-3806	409	5	in	in	ADP
fnp-3806	409	6	the	the	DET
fnp-3806	409	7	number	number	NOUN
fnp-3806	409	8	of	of	ADP
fnp-3806	409	9	machrs	machrs	NOUN
fnp-3806	409	10	in	in	ADP
fnp-3806	409	11	sad	sad	ADJ
fnp-3806	409	12	;	;	PUNCT
fnp-3806	409	13	however	however	ADV
fnp-3806	409	14	,	,	PUNCT
fnp-3806	409	15	the	the	DET
fnp-3806	409	16	interaction	interaction	NOUN
fnp-3806	409	17	of	of	ADP
fnp-3806	409	18	gq/11	gq/11	PROPN
fnp-3806	409	19	protein	protein	NOUN
fnp-3806	409	20	is	be	AUX
fnp-3806	409	21	altered	alter	VERB
fnp-3806	409	22	in	in	ADP
fnp-3806	409	23	sad	sad	ADJ
fnp-3806	409	24	compared	compare	VERB
fnp-3806	409	25	with	with	ADP
fnp-3806	409	26	controls	control	NOUN
fnp-3806	409	27	(	(	PUNCT
fnp-3806	409	28	477	477	NUM
fnp-3806	409	29	)	)	PUNCT
fnp-3806	409	30	.	.	PUNCT
fnp-3806	410	1	m1	m1	NOUN
fnp-3806	410	2	muscarinic	muscarinic	NOUN
fnp-3806	410	3	agonists	agonist	NOUN
fnp-3806	410	4	reduce	reduce	VERB
fnp-3806	410	5	β	β	NOUN
fnp-3806	410	6	-	-	NOUN
fnp-3806	410	7	amyloid	amyloid	NOUN
fnp-3806	410	8	and	and	CCONJ
fnp-3806	410	9	tau	tau	PROPN
fnp-3806	410	10	pathology	pathology	NOUN
fnp-3806	410	11	,	,	PUNCT
fnp-3806	410	12	whereas	whereas	SCONJ
fnp-3806	410	13	m1	m1	NOUN
fnp-3806	410	14	muscarinic	muscarinic	ADJ
fnp-3806	410	15	antagonists	antagonist	NOUN
fnp-3806	410	16	or	or	CCONJ
fnp-3806	410	17	deletion	deletion	NOUN
fnp-3806	410	18	of	of	ADP
fnp-3806	410	19	m1	m1	NOUN
fnp-3806	410	20	subtype	subtype	NOUN
fnp-3806	410	21	augment	augment	NOUN
fnp-3806	410	22	β	β	NOUN
fnp-3806	410	23	-	-	NOUN
fnp-3806	410	24	amyloid	amyloid	NOUN
fnp-3806	410	25	and	and	CCONJ
fnp-3806	410	26	tau	tau	PROPN
fnp-3806	410	27	pathology	pathology	NOUN
fnp-3806	410	28	in	in	ADP
fnp-3806	410	29	in	in	ADP
fnp-3806	410	30	vitro	vitro	X
fnp-3806	410	31	and	and	CCONJ
fnp-3806	410	32	in	in	ADP
fnp-3806	410	33	vivo	vivo	ADJ
fnp-3806	410	34	murine	murine	ADJ
fnp-3806	410	35	models	model	NOUN
fnp-3806	410	36	of	of	ADP
fnp-3806	410	37	ad	ad	NOUN
fnp-3806	410	38	(	(	PUNCT
fnp-3806	410	39	478	478	NUM
fnp-3806	410	40	-	-	NUM
fnp-3806	410	41	480	480	NUM
fnp-3806	410	42	)	)	PUNCT
fnp-3806	410	43	.	.	PUNCT
fnp-3806	411	1	sps	sps	PROPN
fnp-3806	411	2	have	have	VERB
fnp-3806	411	3	low	low	ADJ
fnp-3806	411	4	levels	level	NOUN
fnp-3806	411	5	of	of	ADP
fnp-3806	411	6	ache	ache	PROPN
fnp-3806	411	7	,	,	PUNCT
fnp-3806	411	8	but	but	CCONJ
fnp-3806	411	9	the	the	DET
fnp-3806	411	10	activity	activity	NOUN
fnp-3806	411	11	of	of	ADP
fnp-3806	411	12	ache	ache	ADV
fnp-3806	411	13	increases	increase	VERB
fnp-3806	411	14	around	around	ADP
fnp-3806	411	15	β	β	NOUN
fnp-3806	411	16	-	-	NOUN
fnp-3806	411	17	amyloid	amyloid	ADJ
fnp-3806	411	18	plaques	plaque	NOUN
fnp-3806	411	19	(	(	PUNCT
fnp-3806	411	20	481	481	NUM
fnp-3806	411	21	,	,	PUNCT
fnp-3806	411	22	482	482	NUM
fnp-3806	411	23	)	)	PUNCT
fnp-3806	411	24	.	.	PUNCT
fnp-3806	412	1	ache	ache	PROPN
fnp-3806	412	2	inhibitors	inhibitor	NOUN
fnp-3806	412	3	such	such	ADJ
fnp-3806	412	4	as	as	ADP
fnp-3806	412	5	donepezil	donepezil	NOUN
fnp-3806	412	6	,	,	PUNCT
fnp-3806	412	7	galantamine	galantamine	NOUN
fnp-3806	412	8	,	,	PUNCT
fnp-3806	412	9	tacrine	tacrine	NOUN
fnp-3806	412	10	,	,	PUNCT
fnp-3806	412	11	and	and	CCONJ
fnp-3806	412	12	rivastigmine	rivastigmine	NOUN
fnp-3806	412	13	are	be	AUX
fnp-3806	412	14	administered	administer	VERB
fnp-3806	412	15	at	at	ADP
fnp-3806	412	16	the	the	DET
fnp-3806	412	17	initial	initial	ADJ
fnp-3806	412	18	stages	stage	NOUN
fnp-3806	412	19	of	of	ADP
fnp-3806	412	20	sad	sad	ADJ
fnp-3806	412	21	.	.	PUNCT
fnp-3806	413	1	7b	7b	NOUN
fnp-3806	413	2	.	.	PUNCT
fnp-3806	414	1	glutamate	glutamate	NOUN
fnp-3806	414	2	and	and	CCONJ
fnp-3806	414	3	glutamate	glutamate	ADJ
fnp-3806	414	4	receptors	receptor	NOUN
fnp-3806	414	5	(	(	PUNCT
fnp-3806	414	6	glurs	glur	NOUN
fnp-3806	414	7	)	)	PUNCT
fnp-3806	414	8	glutamate	glutamate	NOUN
fnp-3806	414	9	is	be	AUX
fnp-3806	414	10	released	release	VERB
fnp-3806	414	11	from	from	ADP
fnp-3806	414	12	synaptic	synaptic	ADJ
fnp-3806	414	13	terminals	terminal	NOUN
fnp-3806	414	14	and	and	CCONJ
fnp-3806	414	15	acts	act	VERB
fnp-3806	414	16	on	on	ADP
fnp-3806	414	17	post	post	ADJ
fnp-3806	414	18	-	-	ADJ
fnp-3806	414	19	synaptic	synaptic	ADJ
fnp-3806	414	20	ionotropic	ionotropic	ADJ
fnp-3806	414	21	glutamate	glutamate	NOUN
fnp-3806	414	22	receptors	receptor	NOUN
fnp-3806	414	23	(	(	PUNCT
fnp-3806	414	24	iglurs	iglur	NOUN
fnp-3806	414	25	)	)	PUNCT
fnp-3806	414	26	.	.	PUNCT
fnp-3806	415	1	this	this	DET
fnp-3806	415	2	mechanism	mechanism	NOUN
fnp-3806	415	3	mediates	mediate	VERB
fnp-3806	415	4	fast	fast	VERB
fnp-3806	415	5	excitatory	excitatory	ADJ
fnp-3806	415	6	synaptic	synaptic	ADJ
fnp-3806	415	7	transmission	transmission	NOUN
fnp-3806	415	8	.	.	PUNCT
fnp-3806	416	1	glutamate	glutamate	NOUN
fnp-3806	416	2	can	can	AUX
fnp-3806	416	3	also	also	ADV
fnp-3806	416	4	act	act	VERB
fnp-3806	416	5	on	on	ADP
fnp-3806	416	6	metabotropic	metabotropic	NOUN
fnp-3806	416	7	glutamate	glutamate	NOUN
fnp-3806	416	8	receptors	receptor	NOUN
fnp-3806	416	9	(	(	PUNCT
fnp-3806	416	10	mglurs	mglur	NOUN
fnp-3806	416	11	)	)	PUNCT
fnp-3806	416	12	.	.	PUNCT
fnp-3806	417	1	the	the	DET
fnp-3806	417	2	mechanism	mechanism	NOUN
fnp-3806	417	3	modulates	modulate	VERB
fnp-3806	417	4	various	various	ADJ
fnp-3806	417	5	effects	effect	NOUN
fnp-3806	417	6	by	by	ADP
fnp-3806	417	7	coupling	couple	VERB
fnp-3806	417	8	to	to	ADP
fnp-3806	417	9	g	g	NOUN
fnp-3806	417	10	proteins	protein	NOUN
fnp-3806	417	11	with	with	ADP
fnp-3806	417	12	subsequent	subsequent	ADJ
fnp-3806	417	13	recruitment	recruitment	NOUN
fnp-3806	417	14	of	of	ADP
fnp-3806	417	15	second	second	ADJ
fnp-3806	417	16	messenger	messenger	NOUN
fnp-3806	417	17	systems	system	NOUN
fnp-3806	417	18	.	.	PUNCT
fnp-3806	418	1	there	there	PRON
fnp-3806	418	2	are	be	VERB
fnp-3806	418	3	three	three	NUM
fnp-3806	418	4	families	family	NOUN
fnp-3806	418	5	of	of	ADP
fnp-3806	418	6	iglurs	iglur	NOUN
fnp-3806	418	7	:	:	PUNCT
fnp-3806	418	8	nmda	nmda	ADJ
fnp-3806	418	9	(	(	PUNCT
fnp-3806	418	10	n	n	CCONJ
fnp-3806	418	11	-	-	PUNCT
fnp-3806	418	12	methyl	methyl	NOUN
fnp-3806	418	13	-	-	PUNCT
fnp-3806	418	14	d	d	NOUN
fnp-3806	418	15	-	-	PUNCT
fnp-3806	418	16	aspartate	aspartate	ADJ
fnp-3806	418	17	receptor	receptor	NOUN
fnp-3806	418	18	)	)	PUNCT
fnp-3806	418	19	,	,	PUNCT
fnp-3806	418	20	ampa	ampa	PROPN
fnp-3806	418	21	(	(	PUNCT
fnp-3806	418	22	α	α	NOUN
fnp-3806	418	23	-	-	PUNCT
fnp-3806	418	24	amino-3	amino-3	ADJ
fnp-3806	418	25	-	-	PUNCT
fnp-3806	418	26	hydroxy-5	hydroxy-5	NUM
fnp-3806	418	27	-	-	PUNCT
fnp-3806	418	28	methyl-4	methyl-4	NOUN
fnp-3806	418	29	-	-	PUNCT
fnp-3806	418	30	isoxazolepropionic	isoxazolepropionic	NOUN
fnp-3806	418	31	acid	acid	NOUN
fnp-3806	418	32	)	)	PUNCT
fnp-3806	418	33	,	,	PUNCT
fnp-3806	418	34	and	and	CCONJ
fnp-3806	418	35	ka	ka	PROPN
fnp-3806	418	36	(	(	PUNCT
fnp-3806	418	37	kainate	kainate	NOUN
fnp-3806	418	38	)	)	PUNCT
fnp-3806	418	39	receptors	receptor	NOUN
fnp-3806	418	40	:	:	PUNCT
fnp-3806	418	41	nmdar	nmdar	ADJ
fnp-3806	418	42	,	,	PUNCT
fnp-3806	418	43	ampar	ampar	NOUN
fnp-3806	418	44	,	,	PUNCT
fnp-3806	418	45	and	and	CCONJ
fnp-3806	418	46	kar	kar	PROPN
fnp-3806	418	47	,	,	PUNCT
fnp-3806	418	48	respectively	respectively	ADV
fnp-3806	418	49	.	.	PUNCT
fnp-3806	419	1	nmdars	nmdar	NOUN
fnp-3806	419	2	are	be	AUX
fnp-3806	419	3	composed	compose	VERB
fnp-3806	419	4	of	of	ADP
fnp-3806	419	5	different	different	ADJ
fnp-3806	419	6	subunits	subunit	NOUN
fnp-3806	419	7	encoded	encode	VERB
fnp-3806	419	8	by	by	ADP
fnp-3806	419	9	glun1	glun1	NOUN
fnp-3806	419	10	(	(	PUNCT
fnp-3806	419	11	nr1	nr1	NOUN
fnp-3806	419	12	)	)	PUNCT
fnp-3806	419	13	,	,	PUNCT
fnp-3806	419	14	glun2a	glun2a	X
fnp-3806	419	15	(	(	PUNCT
fnp-3806	419	16	nr2a	nr2a	NOUN
fnp-3806	419	17	)	)	PUNCT
fnp-3806	419	18	,	,	PUNCT
fnp-3806	419	19	glun2b	glun2b	PROPN
fnp-3806	419	20	(	(	PUNCT
fnp-3806	419	21	nr2b	nr2b	NOUN
fnp-3806	419	22	)	)	PUNCT
fnp-3806	419	23	,	,	PUNCT
fnp-3806	419	24	glun2c	glun2c	PROPN
fnp-3806	419	25	(	(	PUNCT
fnp-3806	419	26	nr2c	nr2c	ADJ
fnp-3806	419	27	)	)	PUNCT
fnp-3806	419	28	,	,	PUNCT
fnp-3806	419	29	glun2d	glun2d	PROPN
fnp-3806	419	30	(	(	PUNCT
fnp-3806	419	31	nr2d	nr2d	PROPN
fnp-3806	419	32	)	)	PUNCT
fnp-3806	419	33	,	,	PUNCT
fnp-3806	419	34	glun3a	glun3a	PROPN
fnp-3806	419	35	(	(	PUNCT
fnp-3806	419	36	nr3a	nr3a	ADV
fnp-3806	419	37	)	)	PUNCT
fnp-3806	419	38	,	,	PUNCT
fnp-3806	419	39	and	and	CCONJ
fnp-3806	419	40	glun3b	glun3b	PROPN
fnp-3806	419	41	(	(	PUNCT
fnp-3806	419	42	nr3b	nr3b	NOUN
fnp-3806	419	43	)	)	PUNCT
fnp-3806	419	44	.	.	PUNCT
fnp-3806	420	1	ampars	ampar	NOUN
fnp-3806	420	2	are	be	AUX
fnp-3806	420	3	composed	compose	VERB
fnp-3806	420	4	of	of	ADP
fnp-3806	420	5	combinations	combination	NOUN
fnp-3806	420	6	of	of	ADP
fnp-3806	420	7	glua1	glua1	NOUN
fnp-3806	420	8	(	(	PUNCT
fnp-3806	420	9	glur1	glur1	PROPN
fnp-3806	420	10	)	)	PUNCT
fnp-3806	420	11	,	,	PUNCT
fnp-3806	420	12	glua2	glua2	PROPN
fnp-3806	420	13	(	(	PUNCT
fnp-3806	420	14	glur2	glur2	NOUN
fnp-3806	420	15	)	)	PUNCT
fnp-3806	420	16	,	,	PUNCT
fnp-3806	420	17	glua3	glua3	PROPN
fnp-3806	420	18	(	(	PUNCT
fnp-3806	420	19	glur3	glur3	PROPN
fnp-3806	420	20	)	)	PUNCT
fnp-3806	420	21	and	and	CCONJ
fnp-3806	420	22	glua4	glua4	PROPN
fnp-3806	420	23	(	(	PUNCT
fnp-3806	420	24	glur4	glur4	NOUN
fnp-3806	420	25	)	)	PUNCT
fnp-3806	420	26	;	;	PUNCT
fnp-3806	420	27	and	and	CCONJ
fnp-3806	420	28	kars	kar	NOUN
fnp-3806	420	29	by	by	ADP
fnp-3806	420	30	gluk1	gluk1	PROPN
fnp-3806	420	31	(	(	PUNCT
fnp-3806	420	32	glur5	glur5	PROPN
fnp-3806	420	33	)	)	PUNCT
fnp-3806	420	34	,	,	PUNCT
fnp-3806	421	1	gluk2	gluk2	NOUN
fnp-3806	421	2	(	(	PUNCT
fnp-3806	421	3	glur6	glur6	PROPN
fnp-3806	421	4	)	)	PUNCT
fnp-3806	421	5	,	,	PUNCT
fnp-3806	422	1	gluk3	gluk3	NOUN
fnp-3806	422	2	(	(	PUNCT
fnp-3806	422	3	glur7	glur7	NOUN
fnp-3806	422	4	)	)	PUNCT
fnp-3806	422	5	,	,	PUNCT
fnp-3806	422	6	gluk4	gluk4	X
fnp-3806	422	7	(	(	PUNCT
fnp-3806	422	8	ka-1	ka-1	NUM
fnp-3806	422	9	)	)	PUNCT
fnp-3806	422	10	and	and	CCONJ
fnp-3806	422	11	gluk5	gluk5	NOUN
fnp-3806	422	12	(	(	PUNCT
fnp-3806	422	13	ka-2	ka-2	ADJ
fnp-3806	422	14	)	)	PUNCT
fnp-3806	422	15	.	.	PUNCT
fnp-3806	423	1	in	in	ADP
fnp-3806	423	2	nmdars	nmdar	NOUN
fnp-3806	423	3	,	,	PUNCT
fnp-3806	423	4	the	the	DET
fnp-3806	423	5	binding	binding	NOUN
fnp-3806	423	6	of	of	ADP
fnp-3806	423	7	glutamate	glutamate	NOUN
fnp-3806	423	8	and	and	CCONJ
fnp-3806	423	9	glycine	glycine	NOUN
fnp-3806	423	10	is	be	AUX
fnp-3806	423	11	necessary	necessary	ADJ
fnp-3806	423	12	to	to	PART
fnp-3806	423	13	activate	activate	VERB
fnp-3806	423	14	glutamate	glutamate	NOUN
fnp-3806	423	15	-	-	PUNCT
fnp-3806	423	16	gated	gate	VERB
fnp-3806	423	17	ion	ion	NOUN
fnp-3806	423	18	channels	channel	NOUN
fnp-3806	423	19	.	.	PUNCT
fnp-3806	424	1	the	the	DET
fnp-3806	424	2	removal	removal	NOUN
fnp-3806	424	3	of	of	ADP
fnp-3806	424	4	magnesium	magnesium	NOUN
fnp-3806	424	5	ions	ion	NOUN
fnp-3806	424	6	(	(	PUNCT
fnp-3806	424	7	mg2	mg2	NOUN
fnp-3806	424	8	+	+	NOUN
fnp-3806	424	9	)	)	PUNCT
fnp-3806	424	10	block	block	NOUN
fnp-3806	424	11	permits	permit	VERB
fnp-3806	424	12	the	the	DET
fnp-3806	424	13	entry	entry	NOUN
fnp-3806	424	14	of	of	ADP
fnp-3806	424	15	calcium	calcium	NOUN
fnp-3806	424	16	ions	ion	NOUN
fnp-3806	424	17	(	(	PUNCT
fnp-3806	424	18	ca2	ca2	PROPN
fnp-3806	424	19	+	+	NOUN
fnp-3806	424	20	)	)	PUNCT
fnp-3806	424	21	and	and	CCONJ
fnp-3806	424	22	synaptic	synaptic	ADJ
fnp-3806	424	23	signaling	signal	VERB
fnp-3806	424	24	(	(	PUNCT
fnp-3806	424	25	483	483	NUM
fnp-3806	424	26	,	,	PUNCT
fnp-3806	424	27	484	484	NUM
fnp-3806	424	28	)	)	PUNCT
fnp-3806	424	29	.	.	PUNCT
fnp-3806	425	1	both	both	DET
fnp-3806	425	2	iglurs	iglur	NOUN
fnp-3806	425	3	and	and	CCONJ
fnp-3806	425	4	mglurs	mglur	NOUN
fnp-3806	425	5	are	be	AUX
fnp-3806	425	6	also	also	ADV
fnp-3806	425	7	localized	localize	VERB
fnp-3806	425	8	pre	pre	ADJ
fnp-3806	425	9	-	-	ADJ
fnp-3806	425	10	synaptically	synaptically	ADV
fnp-3806	425	11	acting	act	VERB
fnp-3806	425	12	as	as	ADP
fnp-3806	425	13	auto	auto	NOUN
fnp-3806	425	14	-	-	PUNCT
fnp-3806	425	15	receptors	receptor	NOUN
fnp-3806	425	16	and	and	CCONJ
fnp-3806	425	17	hetero	hetero	NOUN
fnp-3806	425	18	-	-	PUNCT
fnp-3806	425	19	receptors	receptor	NOUN
fnp-3806	425	20	.	.	PUNCT
fnp-3806	426	1	this	this	DET
fnp-3806	426	2	localization	localization	NOUN
fnp-3806	426	3	facilitates	facilitate	VERB
fnp-3806	426	4	neurotransmission	neurotransmission	NOUN
fnp-3806	426	5	in	in	ADP
fnp-3806	426	6	the	the	DET
fnp-3806	426	7	short	short	ADJ
fnp-3806	426	8	term	term	NOUN
fnp-3806	426	9	and	and	CCONJ
fnp-3806	426	10	depresses	depress	VERB
fnp-3806	426	11	neurotransmission	neurotransmission	NOUN
fnp-3806	426	12	in	in	ADP
fnp-3806	426	13	the	the	DET
fnp-3806	426	14	long	long	ADJ
fnp-3806	426	15	term	term	NOUN
fnp-3806	426	16	(	(	PUNCT
fnp-3806	426	17	485	485	NUM
fnp-3806	426	18	)	)	PUNCT
fnp-3806	426	19	.	.	PUNCT
fnp-3806	427	1	glurs	glur	NOUN
fnp-3806	427	2	are	be	AUX
fnp-3806	427	3	localized	localize	VERB
fnp-3806	427	4	non	non	ADJ
fnp-3806	427	5	-	-	ADJ
fnp-3806	427	6	synaptically	synaptically	ADV
fnp-3806	427	7	and	and	CCONJ
fnp-3806	427	8	are	be	AUX
fnp-3806	427	9	also	also	ADV
fnp-3806	427	10	expressed	express	VERB
fnp-3806	427	11	by	by	ADP
fnp-3806	427	12	astrocytes	astrocyte	NOUN
fnp-3806	427	13	and	and	CCONJ
fnp-3806	427	14	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	427	15	(	(	PUNCT
fnp-3806	427	16	486	486	NUM
fnp-3806	427	17	)	)	PUNCT
fnp-3806	427	18	.	.	PUNCT
fnp-3806	428	1	glutamate	glutamate	VERB
fnp-3806	428	2	binding	bind	VERB
fnp-3806	428	3	to	to	ADP
fnp-3806	428	4	nmdars	nmdar	NOUN
fnp-3806	428	5	,	,	PUNCT
fnp-3806	428	6	ampars	ampar	NOUN
fnp-3806	428	7	,	,	PUNCT
fnp-3806	428	8	and	and	CCONJ
fnp-3806	428	9	kars	kar	NOUN
fnp-3806	428	10	is	be	AUX
fnp-3806	428	11	reduced	reduce	VERB
fnp-3806	428	12	in	in	ADP
fnp-3806	428	13	the	the	DET
fnp-3806	428	14	aging	age	VERB
fnp-3806	428	15	brain	brain	NOUN
fnp-3806	428	16	and	and	CCONJ
fnp-3806	428	17	sad	sad	ADJ
fnp-3806	428	18	mainly	mainly	ADV
fnp-3806	428	19	in	in	ADP
fnp-3806	428	20	the	the	DET
fnp-3806	428	21	cerebral	cerebral	ADJ
fnp-3806	428	22	cortex	cortex	NOUN
fnp-3806	428	23	and	and	CCONJ
fnp-3806	428	24	hippocampus	hippocampus	NOUN
fnp-3806	428	25	.	.	PUNCT
fnp-3806	429	1	these	these	DET
fnp-3806	429	2	changes	change	NOUN
fnp-3806	429	3	are	be	AUX
fnp-3806	429	4	receptor-	receptor-	ADJ
fnp-3806	429	5	,	,	PUNCT
fnp-3806	429	6	region-	region-	X
fnp-3806	429	7	,	,	PUNCT
fnp-3806	429	8	and	and	CCONJ
fnp-3806	429	9	layer	layer	NOUN
fnp-3806	429	10	-	-	PUNCT
fnp-3806	429	11	dependent	dependent	ADJ
fnp-3806	429	12	,	,	PUNCT
fnp-3806	429	13	thus	thus	ADV
fnp-3806	429	14	indicating	indicate	VERB
fnp-3806	429	15	variable	variable	ADJ
fnp-3806	429	16	vulnerability	vulnerability	NOUN
fnp-3806	429	17	.	.	PUNCT
fnp-3806	430	1	altered	altered	ADJ
fnp-3806	430	2	expression	expression	NOUN
fnp-3806	430	3	is	be	AUX
fnp-3806	430	4	likely	likely	ADV
fnp-3806	430	5	dependent	dependent	ADJ
fnp-3806	430	6	on	on	ADP
fnp-3806	430	7	several	several	ADJ
fnp-3806	430	8	factors	factor	NOUN
fnp-3806	430	9	and	and	CCONJ
fnp-3806	430	10	not	not	PART
fnp-3806	430	11	necessarily	necessarily	ADV
fnp-3806	430	12	correlated	correlate	VERB
fnp-3806	430	13	with	with	ADP
fnp-3806	430	14	local	local	ADJ
fnp-3806	430	15	nfts	nft	NOUN
fnp-3806	430	16	and	and	CCONJ
fnp-3806	430	17	sps	sps	NOUN
fnp-3806	430	18	,	,	PUNCT
fnp-3806	430	19	although	although	SCONJ
fnp-3806	430	20	loss	loss	NOUN
fnp-3806	430	21	of	of	ADP
fnp-3806	430	22	neurons	neuron	NOUN
fnp-3806	430	23	and	and	CCONJ
fnp-3806	430	24	reduced	reduce	VERB
fnp-3806	430	25	neuronal	neuronal	ADJ
fnp-3806	430	26	connectivity	connectivity	NOUN
fnp-3806	430	27	may	may	AUX
fnp-3806	430	28	account	account	VERB
fnp-3806	430	29	,	,	PUNCT
fnp-3806	430	30	in	in	ADP
fnp-3806	430	31	part	part	NOUN
fnp-3806	430	32	,	,	PUNCT
fnp-3806	430	33	for	for	ADP
fnp-3806	430	34	the	the	DET
fnp-3806	430	35	decreased	decrease	VERB
fnp-3806	430	36	receptor	receptor	NOUN
fnp-3806	430	37	expression	expression	NOUN
fnp-3806	430	38	(	(	PUNCT
fnp-3806	430	39	440	440	NUM
fnp-3806	430	40	)	)	PUNCT
fnp-3806	430	41	.	.	PUNCT
fnp-3806	431	1	the	the	DET
fnp-3806	431	2	localization	localization	NOUN
fnp-3806	431	3	of	of	ADP
fnp-3806	431	4	the	the	DET
fnp-3806	431	5	receptors	receptor	NOUN
fnp-3806	431	6	also	also	ADV
fnp-3806	431	7	plays	play	VERB
fnp-3806	431	8	a	a	DET
fnp-3806	431	9	cardinal	cardinal	ADJ
fnp-3806	431	10	role	role	NOUN
fnp-3806	431	11	.	.	PUNCT
fnp-3806	432	1	nmdars	nmdar	NOUN
fnp-3806	432	2	containing	contain	VERB
fnp-3806	432	3	glun2a	glun2a	NOUN
fnp-3806	432	4	subunits	subunit	NOUN
fnp-3806	432	5	are	be	AUX
fnp-3806	432	6	located	locate	VERB
fnp-3806	432	7	at	at	ADP
fnp-3806	432	8	synaptic	synaptic	ADJ
fnp-3806	432	9	sites	site	NOUN
fnp-3806	432	10	and	and	CCONJ
fnp-3806	432	11	are	be	AUX
fnp-3806	432	12	implicated	implicate	VERB
fnp-3806	432	13	in	in	ADP
fnp-3806	432	14	the	the	DET
fnp-3806	432	15	protective	protective	ADJ
fnp-3806	432	16	pathways	pathway	NOUN
fnp-3806	432	17	.	.	PUNCT
fnp-3806	433	1	in	in	ADP
fnp-3806	433	2	contrast	contrast	NOUN
fnp-3806	433	3	,	,	PUNCT
fnp-3806	433	4	glun2b	glun2b	NOUN
fnp-3806	433	5	subunits	subunit	NOUN
fnp-3806	433	6	are	be	AUX
fnp-3806	433	7	located	locate	VERB
fnp-3806	433	8	mainly	mainly	ADV
fnp-3806	433	9	at	at	ADP
fnp-3806	433	10	extra	extra	ADJ
fnp-3806	433	11	-	-	ADJ
fnp-3806	433	12	synaptic	synaptic	ADJ
fnp-3806	433	13	sites	site	NOUN
fnp-3806	433	14	,	,	PUNCT
fnp-3806	433	15	and	and	CCONJ
fnp-3806	433	16	they	they	PRON
fnp-3806	433	17	increase	increase	VERB
fnp-3806	433	18	neuronal	neuronal	ADJ
fnp-3806	433	19	vulnerability	vulnerability	NOUN
fnp-3806	433	20	.	.	PUNCT
fnp-3806	434	1	β	β	X
fnp-3806	434	2	-	-	PUNCT
fnp-3806	434	3	amyloid	amyloid	NOUN
fnp-3806	434	4	activates	activate	VERB
fnp-3806	434	5	glun2b	glun2b	NOUN
fnp-3806	434	6	-	-	PUNCT
fnp-3806	434	7	containing	contain	VERB
fnp-3806	434	8	nmdars	nmdar	NOUN
fnp-3806	434	9	(	(	PUNCT
fnp-3806	434	10	487	487	NUM
fnp-3806	434	11	-	-	NUM
fnp-3806	434	12	489	489	NUM
fnp-3806	434	13	)	)	PUNCT
fnp-3806	434	14	.	.	PUNCT
fnp-3806	435	1	in	in	ADP
fnp-3806	435	2	addition	addition	NOUN
fnp-3806	435	3	,	,	PUNCT
fnp-3806	435	4	nmdars	nmdar	NOUN
fnp-3806	435	5	are	be	AUX
fnp-3806	435	6	necessary	necessary	ADJ
fnp-3806	435	7	for	for	ADP
fnp-3806	435	8	synaptic	synaptic	ADJ
fnp-3806	435	9	targeting	targeting	NOUN
fnp-3806	435	10	of	of	ADP
fnp-3806	435	11	aβ	aβ	NOUN
fnp-3806	435	12	oligomers	oligomer	NOUN
fnp-3806	435	13	(	(	PUNCT
fnp-3806	435	14	490	490	NUM
fnp-3806	435	15	)	)	PUNCT
fnp-3806	435	16	and	and	CCONJ
fnp-3806	435	17	neuronal	neuronal	ADJ
fnp-3806	435	18	aβ	aβ	NOUN
fnp-3806	435	19	production	production	NOUN
fnp-3806	435	20	(	(	PUNCT
fnp-3806	435	21	491	491	NUM
fnp-3806	435	22	)	)	PUNCT
fnp-3806	435	23	.	.	PUNCT
fnp-3806	436	1	nmdar	nmdar	PROPN
fnp-3806	436	2	alterations	alteration	NOUN
fnp-3806	436	3	are	be	AUX
fnp-3806	436	4	implicated	implicate	VERB
fnp-3806	436	5	in	in	ADP
fnp-3806	436	6	synaptic	synaptic	ADJ
fnp-3806	436	7	dysfunction	dysfunction	NOUN
fnp-3806	436	8	in	in	ADP
fnp-3806	436	9	sad	sad	ADJ
fnp-3806	436	10	(	(	PUNCT
fnp-3806	436	11	492	492	NUM
fnp-3806	436	12	,	,	PUNCT
fnp-3806	436	13	493	493	NUM
fnp-3806	436	14	)	)	PUNCT
fnp-3806	436	15	.	.	PUNCT
fnp-3806	437	1	nmdars	nmdar	NOUN
fnp-3806	437	2	also	also	ADV
fnp-3806	437	3	participate	participate	VERB
fnp-3806	437	4	in	in	ADP
fnp-3806	437	5	redox	redox	NOUN
fnp-3806	437	6	-	-	PUNCT
fnp-3806	437	7	mediated	mediate	VERB
fnp-3806	437	8	synaptic	synaptic	ADJ
fnp-3806	437	9	function	function	NOUN
fnp-3806	437	10	impairment	impairment	NOUN
fnp-3806	437	11	in	in	ADP
fnp-3806	437	12	brain	brain	NOUN
fnp-3806	437	13	aging	aging	NOUN
fnp-3806	437	14	and	and	CCONJ
fnp-3806	437	15	sad	sad	ADJ
fnp-3806	437	16	(	(	PUNCT
fnp-3806	437	17	494	494	NUM
fnp-3806	437	18	)	)	PUNCT
fnp-3806	437	19	.	.	PUNCT
fnp-3806	438	1	memantine	memantine	PROPN
fnp-3806	438	2	,	,	PUNCT
fnp-3806	438	3	an	an	DET
fnp-3806	438	4	nmdar	nmdar	NOUN
fnp-3806	438	5	antagonist	antagonist	NOUN
fnp-3806	438	6	,	,	PUNCT
fnp-3806	438	7	is	be	AUX
fnp-3806	438	8	currently	currently	ADV
fnp-3806	438	9	used	use	VERB
fnp-3806	438	10	at	at	ADP
fnp-3806	438	11	the	the	DET
fnp-3806	438	12	middle	middle	ADJ
fnp-3806	438	13	clinical	clinical	ADJ
fnp-3806	438	14	stages	stage	NOUN
fnp-3806	438	15	of	of	ADP
fnp-3806	438	16	ad	ad	NOUN
fnp-3806	438	17	to	to	PART
fnp-3806	438	18	reduce	reduce	VERB
fnp-3806	438	19	the	the	DET
fnp-3806	438	20	hyperactivity	hyperactivity	NOUN
fnp-3806	438	21	of	of	ADP
fnp-3806	438	22	glutamate	glutamate	NOUN
fnp-3806	438	23	,	,	PUNCT
fnp-3806	438	24	resulting	result	VERB
fnp-3806	438	25	in	in	ADP
fnp-3806	438	26	transient	transient	ADJ
fnp-3806	438	27	and	and	CCONJ
fnp-3806	438	28	limited	limited	ADJ
fnp-3806	438	29	success	success	NOUN
fnp-3806	438	30	.	.	PUNCT
fnp-3806	439	1	ampars	ampar	NOUN
fnp-3806	439	2	are	be	AUX
fnp-3806	439	3	consistently	consistently	ADV
fnp-3806	439	4	endocytosed	endocytose	VERB
fnp-3806	439	5	.	.	PUNCT
fnp-3806	440	1	the	the	DET
fnp-3806	440	2	increase	increase	NOUN
fnp-3806	440	3	in	in	ADP
fnp-3806	440	4	the	the	DET
fnp-3806	440	5	rate	rate	NOUN
fnp-3806	440	6	of	of	ADP
fnp-3806	440	7	ampa	ampa	NOUN
fnp-3806	440	8	endocytosis	endocytosis	NOUN
fnp-3806	440	9	induces	induce	VERB
fnp-3806	440	10	long	long	ADJ
fnp-3806	440	11	-	-	PUNCT
fnp-3806	440	12	term	term	NOUN
fnp-3806	440	13	depression	depression	NOUN
fnp-3806	440	14	and	and	CCONJ
fnp-3806	440	15	synaptic	synaptic	ADJ
fnp-3806	440	16	degeneration	degeneration	NOUN
fnp-3806	440	17	(	(	PUNCT
fnp-3806	440	18	495	495	NUM
fnp-3806	440	19	)	)	PUNCT
fnp-3806	440	20	.	.	PUNCT
fnp-3806	441	1	soluble	soluble	ADJ
fnp-3806	441	2	aβ	aβ	NOUN
fnp-3806	441	3	oligomers	oligomer	NOUN
fnp-3806	441	4	are	be	AUX
fnp-3806	441	5	involved	involve	VERB
fnp-3806	441	6	in	in	ADP
fnp-3806	441	7	synaptic	synaptic	ADJ
fnp-3806	441	8	damage	damage	NOUN
fnp-3806	441	9	via	via	ADP
fnp-3806	441	10	the	the	DET
fnp-3806	441	11	subunit	subunit	NOUN
fnp-3806	441	12	glua3	glua3	PROPN
fnp-3806	441	13	ampar	ampar	PROPN
fnp-3806	441	14	(	(	PUNCT
fnp-3806	441	15	496	496	NUM
fnp-3806	441	16	)	)	PUNCT
fnp-3806	441	17	.	.	PUNCT
fnp-3806	442	1	aβ	aβ	PRON
fnp-3806	442	2	also	also	ADV
fnp-3806	442	3	induces	induce	VERB
fnp-3806	442	4	ampar	ampar	ADP
fnp-3806	442	5	ubiquitination	ubiquitination	NOUN
fnp-3806	442	6	and	and	CCONJ
fnp-3806	442	7	degradation	degradation	NOUN
fnp-3806	442	8	(	(	PUNCT
fnp-3806	442	9	497	497	NUM
fnp-3806	442	10	)	)	PUNCT
fnp-3806	442	11	.	.	PUNCT
fnp-3806	443	1	glutamate	glutamate	ADJ
fnp-3806	443	2	abnormalities	abnormality	NOUN
fnp-3806	443	3	in	in	ADP
fnp-3806	443	4	aging	age	VERB
fnp-3806	443	5	and	and	CCONJ
fnp-3806	443	6	sad	sad	ADJ
fnp-3806	443	7	are	be	AUX
fnp-3806	443	8	not	not	PART
fnp-3806	443	9	restricted	restrict	VERB
fnp-3806	443	10	to	to	ADP
fnp-3806	443	11	alterations	alteration	NOUN
fnp-3806	443	12	in	in	ADP
fnp-3806	443	13	glutamate	glutamate	ADJ
fnp-3806	443	14	production	production	NOUN
fnp-3806	443	15	and	and	CCONJ
fnp-3806	443	16	its	its	PRON
fnp-3806	443	17	effects	effect	NOUN
fnp-3806	443	18	on	on	ADP
fnp-3806	443	19	synaptic	synaptic	ADJ
fnp-3806	443	20	receptors	receptor	NOUN
fnp-3806	443	21	in	in	ADP
fnp-3806	443	22	neurons	neuron	NOUN
fnp-3806	443	23	and	and	CCONJ
fnp-3806	443	24	glial	glial	ADJ
fnp-3806	443	25	cells	cell	NOUN
fnp-3806	443	26	.	.	PUNCT
fnp-3806	444	1	furthermore	furthermore	ADV
fnp-3806	444	2	,	,	PUNCT
fnp-3806	444	3	glutamate	glutamate	ADJ
fnp-3806	444	4	effects	effect	NOUN
fnp-3806	444	5	in	in	ADP
fnp-3806	444	6	normal	normal	ADJ
fnp-3806	444	7	and	and	CCONJ
fnp-3806	444	8	pathological	pathological	ADJ
fnp-3806	444	9	conditions	condition	NOUN
fnp-3806	444	10	also	also	ADV
fnp-3806	444	11	depend	depend	VERB
fnp-3806	444	12	on	on	ADP
fnp-3806	444	13	glutamate	glutamate	ADJ
fnp-3806	444	14	transport	transport	NOUN
fnp-3806	444	15	by	by	ADP
fnp-3806	444	16	specific	specific	ADJ
fnp-3806	444	17	neuronal	neuronal	ADJ
fnp-3806	444	18	and	and	CCONJ
fnp-3806	444	19	glial	glial	ADJ
fnp-3806	444	20	transporters	transporter	NOUN
fnp-3806	444	21	(	(	PUNCT
fnp-3806	444	22	498	498	NUM
fnp-3806	444	23	)	)	PUNCT
fnp-3806	444	24	.	.	PUNCT
fnp-3806	445	1	excitatory	excitatory	ADJ
fnp-3806	445	2	amino	amino	NOUN
fnp-3806	445	3	acid	acid	NOUN
fnp-3806	445	4	transporters	transporter	NOUN
fnp-3806	445	5	(	(	PUNCT
fnp-3806	445	6	eaats	eaat	NOUN
fnp-3806	445	7	)	)	PUNCT
fnp-3806	445	8	re	re	ADJ
fnp-3806	445	9	-	-	ADJ
fnp-3806	445	10	uptake	uptake	ADJ
fnp-3806	445	11	glutamate	glutamate	NOUN
fnp-3806	445	12	from	from	ADP
fnp-3806	445	13	the	the	DET
fnp-3806	445	14	synaptic	synaptic	ADJ
fnp-3806	445	15	cleft	cleft	NOUN
fnp-3806	445	16	and	and	CCONJ
fnp-3806	445	17	extra	extra	ADJ
fnp-3806	445	18	-	-	ADJ
fnp-3806	445	19	synaptic	synaptic	ADJ
fnp-3806	445	20	sites	site	NOUN
fnp-3806	445	21	,	,	PUNCT
fnp-3806	445	22	and	and	CCONJ
fnp-3806	445	23	transfer	transfer	VERB
fnp-3806	445	24	glutamate	glutamate	NOUN
fnp-3806	445	25	to	to	ADP
fnp-3806	445	26	glial	glial	ADJ
fnp-3806	445	27	cells	cell	NOUN
fnp-3806	445	28	and	and	CCONJ
fnp-3806	445	29	neurons	neuron	NOUN
fnp-3806	445	30	.	.	PUNCT
fnp-3806	446	1	vesicular	vesicular	ADJ
fnp-3806	446	2	glutamate	glutamate	ADJ
fnp-3806	446	3	transporters	transporter	NOUN
fnp-3806	446	4	(	(	PUNCT
fnp-3806	446	5	vgluts	vglut	NOUN
fnp-3806	446	6	)	)	PUNCT
fnp-3806	446	7	move	move	VERB
fnp-3806	446	8	glutamate	glutamate	NOUN
fnp-3806	446	9	from	from	ADP
fnp-3806	446	10	the	the	DET
fnp-3806	446	11	cell	cell	NOUN
fnp-3806	446	12	cytoplasm	cytoplasm	NOUN
fnp-3806	446	13	into	into	ADP
fnp-3806	446	14	synaptic	synaptic	ADJ
fnp-3806	446	15	vesicles	vesicle	NOUN
fnp-3806	446	16	.	.	PUNCT
fnp-3806	447	1	eaats	eaat	NOUN
fnp-3806	447	2	can	can	AUX
fnp-3806	447	3	also	also	ADV
fnp-3806	447	4	transport	transport	VERB
fnp-3806	447	5	l	l	NOUN
fnp-3806	447	6	-	-	NOUN
fnp-3806	447	7	aspartate	aspartate	ADJ
fnp-3806	447	8	and	and	CCONJ
fnp-3806	447	9	d	d	NOUN
fnp-3806	447	10	-	-	NOUN
fnp-3806	447	11	aspartate	aspartate	NOUN
fnp-3806	447	12	.	.	PUNCT
fnp-3806	448	1	eaat1	eaat1	NOUN
fnp-3806	448	2	and	and	CCONJ
fnp-3806	448	3	eaat2	eaat2	NOUN
fnp-3806	448	4	(	(	PUNCT
fnp-3806	448	5	slc1a3	slc1a3	NOUN
fnp-3806	448	6	and	and	CCONJ
fnp-3806	448	7	slc1a2	slc1a2	VERB
fnp-3806	448	8	,	,	PUNCT
fnp-3806	448	9	respectively	respectively	ADV
fnp-3806	448	10	)	)	PUNCT
fnp-3806	448	11	are	be	AUX
fnp-3806	448	12	localized	localize	VERB
fnp-3806	448	13	in	in	ADP
fnp-3806	448	14	astrocytes	astrocyte	NOUN
fnp-3806	448	15	whereas	whereas	SCONJ
fnp-3806	448	16	eeat3	eeat3	ADJ
fnp-3806	448	17	(	(	PUNCT
fnp-3806	448	18	slc1a1	slc1a1	NOUN
fnp-3806	448	19	)	)	PUNCT
fnp-3806	448	20	,	,	PUNCT
fnp-3806	448	21	eaat4	eaat4	PROPN
fnp-3806	448	22	(	(	PUNCT
fnp-3806	448	23	slc1a6	slc1a6	NOUN
fnp-3806	448	24	)	)	PUNCT
fnp-3806	448	25	and	and	CCONJ
fnp-3806	448	26	vgluts	vglut	NOUN
fnp-3806	448	27	1/2/3	1/2/3	NUM
fnp-3806	448	28	(	(	PUNCT
fnp-3806	448	29	slc17a7	slc17a7	PROPN
fnp-3806	448	30	,	,	PUNCT
fnp-3806	448	31	slc17a6	slc17a6	PROPN
fnp-3806	448	32	,	,	PUNCT
fnp-3806	448	33	slc17a8	slc17a8	PROPN
fnp-3806	448	34	,	,	PUNCT
fnp-3806	448	35	respectively	respectively	ADV
fnp-3806	448	36	)	)	PUNCT
fnp-3806	448	37	are	be	AUX
fnp-3806	448	38	found	find	VERB
fnp-3806	448	39	in	in	ADP
fnp-3806	448	40	neurons	neuron	NOUN
fnp-3806	448	41	.	.	PUNCT
fnp-3806	449	1	loss	loss	NOUN
fnp-3806	449	2	of	of	ADP
fnp-3806	449	3	eaat2	eaat2	NOUN
fnp-3806	449	4	occurs	occur	VERB
fnp-3806	449	5	in	in	ADP
fnp-3806	449	6	many	many	ADJ
fnp-3806	449	7	neurodegenerative	neurodegenerative	ADJ
fnp-3806	449	8	diseases	disease	NOUN
fnp-3806	449	9	,	,	PUNCT
fnp-3806	449	10	including	include	VERB
fnp-3806	449	11	sad	sad	ADJ
fnp-3806	449	12	(	(	PUNCT
fnp-3806	449	13	see	see	VERB
fnp-3806	449	14	section	section	NOUN
fnp-3806	449	15	12a	12a	NOUN
fnp-3806	449	16	)	)	PUNCT
fnp-3806	449	17	.	.	PUNCT
fnp-3806	450	1	abnormal	abnormal	ADJ
fnp-3806	450	2	expression	expression	NOUN
fnp-3806	450	3	of	of	ADP
fnp-3806	450	4	vgluts	vglut	NOUN
fnp-3806	450	5	and	and	CCONJ
fnp-3806	450	6	eaats	eaat	NOUN
fnp-3806	450	7	may	may	AUX
fnp-3806	450	8	contribute	contribute	VERB
fnp-3806	450	9	to	to	ADP
fnp-3806	450	10	neuronal	neuronal	ADJ
fnp-3806	450	11	excitotoxicity	excitotoxicity	NOUN
fnp-3806	450	12	and	and	CCONJ
fnp-3806	450	13	neuron	neuron	NOUN
fnp-3806	450	14	demise	demise	NOUN
fnp-3806	450	15	in	in	ADP
fnp-3806	450	16	sad	sad	ADJ
fnp-3806	450	17	(	(	PUNCT
fnp-3806	450	18	499	499	NUM
fnp-3806	450	19	-	-	NUM
fnp-3806	450	20	501	501	NUM
fnp-3806	450	21	)	)	PUNCT
fnp-3806	450	22	.	.	PUNCT
fnp-3806	451	1	mglurs	mglur	NOUN
fnp-3806	451	2	are	be	AUX
fnp-3806	451	3	g	g	NOUN
fnp-3806	451	4	-	-	PUNCT
fnp-3806	451	5	coupled	couple	VERB
fnp-3806	451	6	proteins	protein	NOUN
fnp-3806	451	7	that	that	PRON
fnp-3806	451	8	act	act	VERB
fnp-3806	451	9	upon	upon	SCONJ
fnp-3806	451	10	different	different	ADJ
fnp-3806	451	11	effector	effector	NOUN
fnp-3806	451	12	systems	system	NOUN
fnp-3806	451	13	,	,	PUNCT
fnp-3806	451	14	including	include	VERB
fnp-3806	451	15	plc	plc	PROPN
fnp-3806	451	16	and	and	CCONJ
fnp-3806	451	17	ac	ac	PROPN
fnp-3806	451	18	.	.	PUNCT
fnp-3806	452	1	mglurs	mglur	NOUN
fnp-3806	452	2	are	be	AUX
fnp-3806	452	3	classified	classify	VERB
fnp-3806	452	4	into	into	ADP
fnp-3806	452	5	three	three	NUM
fnp-3806	452	6	groups	group	NOUN
fnp-3806	452	7	based	base	VERB
fnp-3806	452	8	on	on	ADP
fnp-3806	452	9	their	their	PRON
fnp-3806	452	10	pharmacological	pharmacological	ADJ
fnp-3806	452	11	profiles	profile	NOUN
fnp-3806	452	12	,	,	PUNCT
fnp-3806	452	13	molecular	molecular	ADJ
fnp-3806	452	14	properties	property	NOUN
fnp-3806	452	15	,	,	PUNCT
fnp-3806	452	16	and	and	CCONJ
fnp-3806	452	17	transduction	transduction	NOUN
fnp-3806	452	18	mechanisms	mechanism	NOUN
fnp-3806	452	19	.	.	PUNCT
fnp-3806	453	1	group	group	NOUN
fnp-3806	453	2	i	i	PRON
fnp-3806	453	3	receptors	receptor	NOUN
fnp-3806	453	4	(	(	PUNCT
fnp-3806	453	5	mglur1	mglur1	NOUN
fnp-3806	453	6	,	,	PUNCT
fnp-3806	453	7	mglur5	mglur5	PROPN
fnp-3806	453	8	)	)	PUNCT
fnp-3806	453	9	are	be	AUX
fnp-3806	453	10	coupled	couple	VERB
fnp-3806	453	11	to	to	ADP
fnp-3806	453	12	plc	plc	PROPN
fnp-3806	453	13	activation	activation	NOUN
fnp-3806	453	14	through	through	ADP
fnp-3806	453	15	gq/11	gq/11	PROPN
fnp-3806	453	16	proteins	protein	NOUN
fnp-3806	453	17	,	,	PUNCT
fnp-3806	453	18	whereas	whereas	SCONJ
fnp-3806	453	19	groups	group	NOUN
fnp-3806	453	20	ii	ii	PROPN
fnp-3806	453	21	and	and	CCONJ
fnp-3806	453	22	iii	iii	NUM
fnp-3806	453	23	are	be	AUX
fnp-3806	453	24	coupled	couple	VERB
fnp-3806	453	25	to	to	PART
fnp-3806	453	26	ac	ac	VERB
fnp-3806	453	27	inhibition	inhibition	NOUN
fnp-3806	453	28	through	through	ADP
fnp-3806	453	29	gi	gi	NOUN
fnp-3806	453	30	/	/	SYM
fnp-3806	453	31	o	o	NOUN
fnp-3806	453	32	proteins	protein	NOUN
fnp-3806	453	33	.	.	PUNCT
fnp-3806	454	1	mglur1/5	mglur1/5	NOUN
fnp-3806	454	2	are	be	AUX
fnp-3806	454	3	primarily	primarily	ADV
fnp-3806	454	4	excitatory	excitatory	ADJ
fnp-3806	454	5	,	,	PUNCT
fnp-3806	454	6	and	and	CCONJ
fnp-3806	454	7	mglur2/3	mglur2/3	PROPN
fnp-3806	454	8	and	and	CCONJ
fnp-3806	454	9	mglur4/5/6,7/8	mglur4/5/6,7/8	PROPN
fnp-3806	454	10	are	be	AUX
fnp-3806	454	11	inhibitory	inhibitory	ADJ
fnp-3806	454	12	(	(	PUNCT
fnp-3806	454	13	502	502	NUM
fnp-3806	454	14	-	-	SYM
fnp-3806	454	15	505	505	NUM
fnp-3806	454	16	)	)	PUNCT
fnp-3806	454	17	.	.	PUNCT
fnp-3806	455	1	mglurs	mglur	NOUN
fnp-3806	455	2	,	,	PUNCT
fnp-3806	455	3	determined	determine	VERB
fnp-3806	455	4	by	by	ADP
fnp-3806	455	5	radioligand	radioligand	NOUN
fnp-3806	455	6	binding	bind	VERB
fnp-3806	455	7	assays	assay	NOUN
fnp-3806	455	8	,	,	PUNCT
fnp-3806	455	9	and	and	CCONJ
fnp-3806	455	10	expression	expression	NOUN
fnp-3806	455	11	levels	level	NOUN
fnp-3806	455	12	of	of	ADP
fnp-3806	455	13	mglur1	mglur1	NOUN
fnp-3806	455	14	,	,	PUNCT
fnp-3806	455	15	detected	detect	VERB
fnp-3806	455	16	by	by	ADP
fnp-3806	455	17	western	western	ADJ
fnp-3806	455	18	blotting	blotting	NOUN
fnp-3806	455	19	,	,	PUNCT
fnp-3806	455	20	are	be	AUX
fnp-3806	455	21	significantly	significantly	ADV
fnp-3806	455	22	decreased	decrease	VERB
fnp-3806	455	23	in	in	ADP
fnp-3806	455	24	the	the	DET
fnp-3806	455	25	frontal	frontal	ADJ
fnp-3806	455	26	cortex	cortex	NOUN
fnp-3806	455	27	in	in	ADP
fnp-3806	455	28	sad	sad	ADJ
fnp-3806	455	29	.	.	PUNCT
fnp-3806	456	1	this	this	DET
fnp-3806	456	2	decrease	decrease	NOUN
fnp-3806	456	3	is	be	AUX
fnp-3806	456	4	already	already	ADV
fnp-3806	456	5	observed	observe	VERB
fnp-3806	456	6	at	at	ADP
fnp-3806	456	7	nft	nft	PROPN
fnp-3806	456	8	stages	stage	NOUN
fnp-3806	456	9	i	i	PROPN
fnp-3806	456	10	-	-	PUNCT
fnp-3806	456	11	ii	ii	PROPN
fnp-3806	456	12	and	and	CCONJ
fnp-3806	456	13	iii	iii	NUM
fnp-3806	456	14	-	-	PUNCT
fnp-3806	456	15	iv	iv	NOUN
fnp-3806	456	16	not	not	PART
fnp-3806	456	17	involving	involve	VERB
fnp-3806	456	18	the	the	DET
fnp-3806	456	19	frontal	frontal	ADJ
fnp-3806	456	20	cortex	cortex	NOUN
fnp-3806	456	21	,	,	PUNCT
fnp-3806	456	22	and	and	CCONJ
fnp-3806	456	23	further	further	ADJ
fnp-3806	456	24	decrease	decrease	NOUN
fnp-3806	456	25	with	with	ADP
fnp-3806	456	26	the	the	DET
fnp-3806	456	27	appearance	appearance	NOUN
fnp-3806	456	28	of	of	ADP
fnp-3806	456	29	nfts	nft	NOUN
fnp-3806	456	30	in	in	ADP
fnp-3806	456	31	the	the	DET
fnp-3806	456	32	frontal	frontal	ADJ
fnp-3806	456	33	cortex	cortex	NOUN
fnp-3806	456	34	with	with	ADP
fnp-3806	456	35	disease	disease	NOUN
fnp-3806	456	36	progression	progression	NOUN
fnp-3806	456	37	.	.	PUNCT
fnp-3806	457	1	the	the	DET
fnp-3806	457	2	expression	expression	NOUN
fnp-3806	457	3	levels	level	NOUN
fnp-3806	457	4	of	of	ADP
fnp-3806	457	5	phospholipase	phospholipase	PROPN
fnp-3806	457	6	cβ1	cβ1	PROPN
fnp-3806	457	7	(	(	PUNCT
fnp-3806	457	8	plcβ1	plcβ1	NOUN
fnp-3806	457	9	)	)	PUNCT
fnp-3806	457	10	isoform	isoform	NOUN
fnp-3806	457	11	,	,	PUNCT
fnp-3806	457	12	which	which	PRON
fnp-3806	457	13	is	be	AUX
fnp-3806	457	14	the	the	DET
fnp-3806	457	15	effector	effector	NOUN
fnp-3806	457	16	of	of	ADP
fnp-3806	457	17	group	group	NOUN
fnp-3806	457	18	i	i	PRON
fnp-3806	457	19	mglurs	mglur	NOUN
fnp-3806	457	20	,	,	PUNCT
fnp-3806	457	21	is	be	AUX
fnp-3806	457	22	decreased	decrease	VERB
fnp-3806	457	23	in	in	ADP
fnp-3806	457	24	parallel	parallel	NOUN
fnp-3806	457	25	.	.	PUNCT
fnp-3806	458	1	plcβ1	plcβ1	PROPN
fnp-3806	458	2	decrease	decrease	NOUN
fnp-3806	458	3	,	,	PUNCT
fnp-3806	458	4	in	in	ADP
fnp-3806	458	5	turn	turn	NOUN
fnp-3806	458	6	,	,	PUNCT
fnp-3806	458	7	is	be	AUX
fnp-3806	458	8	associated	associate	VERB
fnp-3806	458	9	with	with	ADP
fnp-3806	458	10	reduced	reduce	VERB
fnp-3806	458	11	gtpand	gtpand	ADJ
fnp-3806	458	12	l	l	NOUN
fnp-3806	458	13	-	-	NOUN
fnp-3806	458	14	glutamate	glutamate	NOUN
fnp-3806	458	15	-	-	PUNCT
fnp-3806	458	16	stimulated	stimulate	VERB
fnp-3806	458	17	plc	plc	NOUN
fnp-3806	458	18	activity	activity	NOUN
fnp-3806	458	19	in	in	ADP
fnp-3806	458	20	sad	sad	ADJ
fnp-3806	458	21	.	.	PUNCT
fnp-3806	459	1	these	these	DET
fnp-3806	459	2	results	result	NOUN
fnp-3806	459	3	show	show	VERB
fnp-3806	459	4	that	that	SCONJ
fnp-3806	459	5	group	group	NOUN
fnp-3806	459	6	i	i	PRON
fnp-3806	459	7	mglurs	mglur	NOUN
fnp-3806	459	8	/	/	SYM
fnp-3806	459	9	plc	plc	PROPN
fnp-3806	459	10	signaling	signal	VERB
fnp-3806	459	11	is	be	AUX
fnp-3806	459	12	downregulated	downregulate	VERB
fnp-3806	459	13	and	and	CCONJ
fnp-3806	459	14	desensitized	desensitize	VERB
fnp-3806	459	15	in	in	ADP
fnp-3806	459	16	the	the	DET
fnp-3806	459	17	frontal	frontal	ADJ
fnp-3806	459	18	cortex	cortex	NOUN
fnp-3806	459	19	at	at	ADP
fnp-3806	459	20	the	the	DET
fnp-3806	459	21	first	first	ADJ
fnp-3806	459	22	stages	stage	NOUN
fnp-3806	459	23	of	of	ADP
fnp-3806	459	24	nft	nft	PROPN
fnp-3806	459	25	pathology	pathology	PROPN
fnp-3806	459	26	,	,	PUNCT
fnp-3806	459	27	and	and	CCONJ
fnp-3806	459	28	that	that	SCONJ
fnp-3806	459	29	these	these	DET
fnp-3806	459	30	modifications	modification	NOUN
fnp-3806	459	31	worsen	worsen	VERB
fnp-3806	459	32	with	with	ADP
fnp-3806	459	33	the	the	DET
fnp-3806	459	34	progression	progression	NOUN
fnp-3806	459	35	of	of	ADP
fnp-3806	459	36	sad	sad	ADJ
fnp-3806	459	37	(	(	PUNCT
fnp-3806	459	38	506	506	NUM
fnp-3806	459	39	)	)	PUNCT
fnp-3806	459	40	.	.	PUNCT
fnp-3806	460	1	7c	7c	NUM
fnp-3806	460	2	.	.	PUNCT
fnp-3806	461	1	γ	γ	X
fnp-3806	461	2	-	-	ADJ
fnp-3806	461	3	aminobutyric	aminobutyric	ADJ
fnp-3806	461	4	acid	acid	NOUN
fnp-3806	461	5	(	(	PUNCT
fnp-3806	461	6	gaba	gaba	PROPN
fnp-3806	461	7	)	)	PUNCT
fnp-3806	461	8	and	and	CCONJ
fnp-3806	461	9	gaba	gaba	NOUN
fnp-3806	461	10	receptors	receptor	NOUN
fnp-3806	461	11	the	the	DET
fnp-3806	461	12	inhibitory	inhibitory	ADJ
fnp-3806	461	13	neurotransmitter	neurotransmitter	NOUN
fnp-3806	461	14	gaba	gaba	PROPN
fnp-3806	461	15	is	be	AUX
fnp-3806	461	16	generated	generate	VERB
fnp-3806	461	17	by	by	ADP
fnp-3806	461	18	α	α	NOUN
fnp-3806	461	19	-	-	NOUN
fnp-3806	461	20	decarboxylation	decarboxylation	NOUN
fnp-3806	461	21	from	from	ADP
fnp-3806	461	22	l	l	NOUN
fnp-3806	461	23	-	-	NOUN
fnp-3806	461	24	glutamate	glutamate	NOUN
fnp-3806	461	25	in	in	ADP
fnp-3806	461	26	neurons	neuron	NOUN
fnp-3806	461	27	by	by	ADP
fnp-3806	461	28	the	the	DET
fnp-3806	461	29	action	action	NOUN
fnp-3806	461	30	of	of	ADP
fnp-3806	461	31	glutamic	glutamic	ADJ
fnp-3806	461	32	acid	acid	NOUN
fnp-3806	461	33	decarboxylase	decarboxylase	PROPN
fnp-3806	461	34	(	(	PUNCT
fnp-3806	461	35	gad	gad	PROPN
fnp-3806	461	36	)	)	PUNCT
fnp-3806	461	37	.	.	PUNCT
fnp-3806	462	1	gaba	gaba	PROPN
fnp-3806	462	2	is	be	AUX
fnp-3806	462	3	then	then	ADV
fnp-3806	462	4	incorporated	incorporate	VERB
fnp-3806	462	5	into	into	ADP
fnp-3806	462	6	the	the	DET
fnp-3806	462	7	synaptic	synaptic	ADJ
fnp-3806	462	8	vesicles	vesicle	NOUN
fnp-3806	462	9	by	by	ADP
fnp-3806	462	10	vesicular	vesicular	ADJ
fnp-3806	462	11	gaba	gaba	NOUN
fnp-3806	462	12	transporter	transporter	NOUN
fnp-3806	462	13	(	(	PUNCT
fnp-3806	462	14	vgat	vgat	NOUN
fnp-3806	462	15	)	)	PUNCT
fnp-3806	462	16	.	.	PUNCT
fnp-3806	463	1	after	after	ADP
fnp-3806	463	2	release	release	NOUN
fnp-3806	463	3	from	from	ADP
fnp-3806	463	4	synaptic	synaptic	ADJ
fnp-3806	463	5	vesicles	vesicle	NOUN
fnp-3806	463	6	,	,	PUNCT
fnp-3806	463	7	gaba	gaba	PROPN
fnp-3806	463	8	binds	bind	VERB
fnp-3806	463	9	to	to	PART
fnp-3806	463	10	ionotropic	ionotropic	ADJ
fnp-3806	463	11	gabaa	gabaa	NOUN
fnp-3806	463	12	and	and	CCONJ
fnp-3806	463	13	metabotropic	metabotropic	NOUN
fnp-3806	463	14	gabab	gabab	NOUN
fnp-3806	463	15	receptors	receptor	NOUN
fnp-3806	463	16	.	.	PUNCT
fnp-3806	464	1	gabaa	gabaa	NOUN
fnp-3806	464	2	receptor	receptor	NOUN
fnp-3806	464	3	activation	activation	NOUN
fnp-3806	464	4	opens	open	VERB
fnp-3806	464	5	chloride	chloride	NOUN
fnp-3806	464	6	ion	ion	NOUN
fnp-3806	464	7	channels	channel	NOUN
fnp-3806	464	8	;	;	PUNCT
fnp-3806	464	9	gabab	gabab	NOUN
fnp-3806	464	10	acts	act	VERB
fnp-3806	464	11	through	through	ADP
fnp-3806	464	12	g	g	PROPN
fnp-3806	464	13	proteins	protein	NOUN
fnp-3806	464	14	,	,	PUNCT
fnp-3806	464	15	reduces	reduce	VERB
fnp-3806	464	16	calcium	calcium	NOUN
fnp-3806	464	17	ion	ion	NOUN
fnp-3806	464	18	channels	channel	NOUN
fnp-3806	464	19	,	,	PUNCT
fnp-3806	464	20	and	and	CCONJ
fnp-3806	464	21	inhibits	inhibit	VERB
fnp-3806	464	22	ac	ac	PROPN
fnp-3806	464	23	and	and	CCONJ
fnp-3806	464	24	intracellular	intracellular	ADJ
fnp-3806	464	25	production	production	NOUN
fnp-3806	464	26	of	of	ADP
fnp-3806	464	27	camp	camp	NOUN
fnp-3806	464	28	(	(	PUNCT
fnp-3806	464	29	507	507	NUM
fnp-3806	464	30	-	-	SYM
fnp-3806	464	31	510	510	NUM
fnp-3806	464	32	)	)	PUNCT
fnp-3806	464	33	.	.	PUNCT
fnp-3806	465	1	gabaa	gabaa	NOUN
fnp-3806	465	2	receptors	receptor	NOUN
fnp-3806	465	3	are	be	AUX
fnp-3806	465	4	composed	compose	VERB
fnp-3806	465	5	of	of	ADP
fnp-3806	465	6	combinations	combination	NOUN
fnp-3806	465	7	of	of	ADP
fnp-3806	465	8	five	five	NUM
fnp-3806	465	9	different	different	ADJ
fnp-3806	465	10	subunits	subunit	NOUN
fnp-3806	465	11	,	,	PUNCT
fnp-3806	465	12	α1	α1	NOUN
fnp-3806	465	13	-	-	PUNCT
fnp-3806	465	14	α6	α6	NOUN
fnp-3806	465	15	,	,	PUNCT
fnp-3806	465	16	β1	β1	NOUN
fnp-3806	465	17	-	-	PUNCT
fnp-3806	465	18	β3	β3	ADJ
fnp-3806	465	19	,	,	PUNCT
fnp-3806	465	20	γ1	γ1	NOUN
fnp-3806	465	21	-	-	PUNCT
fnp-3806	465	22	γ3	γ3	NOUN
fnp-3806	465	23	,	,	PUNCT
fnp-3806	465	24	δ	δ	PROPN
fnp-3806	465	25	,	,	PUNCT
fnp-3806	465	26	ε	ε	PROPN
fnp-3806	465	27	,	,	PUNCT
fnp-3806	465	28	θ	θ	PROPN
fnp-3806	465	29	,	,	PUNCT
fnp-3806	465	30	π	π	PROPN
fnp-3806	465	31	,	,	PUNCT
fnp-3806	465	32	and	and	CCONJ
fnp-3806	465	33	ρ1	ρ1	NOUN
fnp-3806	465	34	-	-	PUNCT
fnp-3806	465	35	ρ2	ρ2	NOUN
fnp-3806	465	36	.	.	PUNCT
fnp-3806	466	1	the	the	DET
fnp-3806	466	2	most	most	ADV
fnp-3806	466	3	frequent	frequent	ADJ
fnp-3806	466	4	pentamers	pentamer	NOUN
fnp-3806	466	5	are	be	AUX
fnp-3806	466	6	2α:2β:1γ	2α:2β:1γ	NUM
fnp-3806	466	7	(	(	PUNCT
fnp-3806	466	8	507	507	NUM
fnp-3806	466	9	)	)	PUNCT
fnp-3806	466	10	.	.	PUNCT
fnp-3806	467	1	gabab	gabab	NOUN
fnp-3806	467	2	receptors	receptor	NOUN
fnp-3806	467	3	are	be	AUX
fnp-3806	467	4	heterodimers	heterodimer	NOUN
fnp-3806	467	5	composed	compose	VERB
fnp-3806	467	6	of	of	ADP
fnp-3806	467	7	r1	r1	PROPN
fnp-3806	467	8	and	and	CCONJ
fnp-3806	467	9	r2	r2	PROPN
fnp-3806	467	10	subunits	subunit	NOUN
fnp-3806	467	11	(	(	PUNCT
fnp-3806	467	12	508	508	NUM
fnp-3806	467	13	)	)	PUNCT
fnp-3806	467	14	.	.	PUNCT
fnp-3806	468	1	gaba	gaba	PROPN
fnp-3806	468	2	at	at	ADP
fnp-3806	468	3	the	the	DET
fnp-3806	468	4	synapses	synapsis	NOUN
fnp-3806	468	5	is	be	AUX
fnp-3806	468	6	picked	pick	VERB
fnp-3806	468	7	up	up	ADP
fnp-3806	468	8	by	by	ADP
fnp-3806	468	9	astrocytes	astrocyte	NOUN
fnp-3806	468	10	that	that	PRON
fnp-3806	468	11	catalyze	catalyze	VERB
fnp-3806	468	12	it	it	PRON
fnp-3806	468	13	to	to	ADP
fnp-3806	468	14	glutamine	glutamine	NOUN
fnp-3806	468	15	,	,	PUNCT
fnp-3806	468	16	which	which	PRON
fnp-3806	468	17	is	be	AUX
fnp-3806	468	18	then	then	ADV
fnp-3806	468	19	transported	transport	VERB
fnp-3806	468	20	into	into	ADP
fnp-3806	468	21	neurons	neuron	NOUN
fnp-3806	468	22	and	and	CCONJ
fnp-3806	468	23	converted	convert	VERB
fnp-3806	468	24	to	to	ADP
fnp-3806	468	25	glutamate	glutamate	VERB
fnp-3806	468	26	(	(	PUNCT
fnp-3806	468	27	511	511	NUM
fnp-3806	468	28	,	,	PUNCT
fnp-3806	468	29	512	512	NUM
fnp-3806	468	30	)	)	PUNCT
fnp-3806	468	31	.	.	PUNCT
fnp-3806	469	1	the	the	DET
fnp-3806	469	2	involvement	involvement	NOUN
fnp-3806	469	3	of	of	ADP
fnp-3806	469	4	astrocytes	astrocyte	NOUN
fnp-3806	469	5	in	in	ADP
fnp-3806	469	6	gaba	gaba	PROPN
fnp-3806	469	7	metabolism	metabolism	NOUN
fnp-3806	469	8	has	have	AUX
fnp-3806	469	9	suggested	suggest	VERB
fnp-3806	469	10	a	a	DET
fnp-3806	469	11	potential	potential	ADJ
fnp-3806	469	12	role	role	NOUN
fnp-3806	469	13	of	of	ADP
fnp-3806	469	14	astrocytes	astrocyte	NOUN
fnp-3806	469	15	in	in	ADP
fnp-3806	469	16	gaba	gaba	PROPN
fnp-3806	469	17	gliotransmission	gliotransmission	NOUN
fnp-3806	469	18	(	(	PUNCT
fnp-3806	469	19	513	513	NUM
fnp-3806	469	20	)	)	PUNCT
fnp-3806	469	21	.	.	PUNCT
fnp-3806	470	1	several	several	ADJ
fnp-3806	470	2	studies	study	NOUN
fnp-3806	470	3	have	have	AUX
fnp-3806	470	4	shown	show	VERB
fnp-3806	470	5	inconsistent	inconsistent	ADJ
fnp-3806	470	6	results	result	NOUN
fnp-3806	470	7	regarding	regard	VERB
fnp-3806	470	8	total	total	ADJ
fnp-3806	470	9	gaba	gaba	NOUN
fnp-3806	470	10	levels	level	NOUN
fnp-3806	470	11	in	in	ADP
fnp-3806	470	12	sad	sad	ADJ
fnp-3806	470	13	but	but	CCONJ
fnp-3806	470	14	there	there	PRON
fnp-3806	470	15	is	be	VERB
fnp-3806	470	16	a	a	DET
fnp-3806	470	17	trend	trend	NOUN
fnp-3806	470	18	toward	toward	ADP
fnp-3806	470	19	stressing	stress	VERB
fnp-3806	470	20	abnormal	abnormal	ADJ
fnp-3806	470	21	gabaergic	gabaergic	ADJ
fnp-3806	470	22	function	function	NOUN
fnp-3806	470	23	(	(	PUNCT
fnp-3806	470	24	514	514	NUM
fnp-3806	470	25	-	-	SYM
fnp-3806	470	26	516	516	NUM
fnp-3806	470	27	)	)	PUNCT
fnp-3806	470	28	.	.	PUNCT
fnp-3806	471	1	reduced	reduce	VERB
fnp-3806	471	2	gaba	gaba	PROPN
fnp-3806	471	3	,	,	PUNCT
fnp-3806	471	4	glutamate	glutamate	NOUN
fnp-3806	471	5	,	,	PUNCT
fnp-3806	471	6	and	and	CCONJ
fnp-3806	471	7	glutamine	glutamine	NOUN
fnp-3806	471	8	levels	level	NOUN
fnp-3806	471	9	are	be	AUX
fnp-3806	471	10	observed	observe	VERB
fnp-3806	471	11	in	in	ADP
fnp-3806	471	12	individuals	individual	NOUN
fnp-3806	471	13	with	with	ADP
fnp-3806	471	14	mci	mci	NOUN
fnp-3806	471	15	and	and	CCONJ
fnp-3806	471	16	ad	ad	NOUN
fnp-3806	471	17	as	as	SCONJ
fnp-3806	471	18	revealed	reveal	VERB
fnp-3806	471	19	by	by	ADP
fnp-3806	471	20	magnetic	magnetic	ADJ
fnp-3806	471	21	resonance	resonance	NOUN
fnp-3806	471	22	spectroscopy	spectroscopy	NOUN
fnp-3806	471	23	(	(	PUNCT
fnp-3806	471	24	517	517	NUM
fnp-3806	471	25	-	-	SYM
fnp-3806	471	26	520	520	NUM
fnp-3806	471	27	)	)	PUNCT
fnp-3806	471	28	.	.	PUNCT
fnp-3806	472	1	regarding	regard	VERB
fnp-3806	472	2	gaba	gaba	NOUN
fnp-3806	472	3	receptors	receptor	NOUN
fnp-3806	472	4	,	,	PUNCT
fnp-3806	472	5	electrophysiological	electrophysiological	ADJ
fnp-3806	472	6	studies	study	NOUN
fnp-3806	472	7	reveal	reveal	VERB
fnp-3806	472	8	a	a	DET
fnp-3806	472	9	reduction	reduction	NOUN
fnp-3806	472	10	in	in	ADP
fnp-3806	472	11	gaba	gaba	NOUN
fnp-3806	472	12	currents	current	NOUN
fnp-3806	472	13	in	in	ADP
fnp-3806	472	14	the	the	DET
fnp-3806	472	15	temporal	temporal	ADJ
fnp-3806	472	16	cortex	cortex	NOUN
fnp-3806	472	17	in	in	ADP
fnp-3806	472	18	sad	sad	ADJ
fnp-3806	472	19	.	.	PUNCT
fnp-3806	473	1	this	this	PRON
fnp-3806	473	2	is	be	AUX
fnp-3806	473	3	associated	associate	VERB
fnp-3806	473	4	with	with	ADP
fnp-3806	473	5	mrna	mrna	PROPN
fnp-3806	473	6	downregulation	downregulation	NOUN
fnp-3806	473	7	of	of	ADP
fnp-3806	473	8	α1	α1	PROPN
fnp-3806	473	9	and	and	CCONJ
fnp-3806	473	10	γ2	γ2	ADJ
fnp-3806	473	11	subunits	subunit	NOUN
fnp-3806	473	12	and	and	CCONJ
fnp-3806	473	13	upregulation	upregulation	NOUN
fnp-3806	473	14	of	of	ADP
fnp-3806	473	15	α2	α2	PROPN
fnp-3806	473	16	,	,	PUNCT
fnp-3806	473	17	β1	β1	PROPN
fnp-3806	473	18	,	,	PUNCT
fnp-3806	473	19	and	and	CCONJ
fnp-3806	473	20	γ1	γ1	PROPN
fnp-3806	473	21	transcripts	transcript	NOUN
fnp-3806	473	22	(	(	PUNCT
fnp-3806	473	23	521	521	NUM
fnp-3806	473	24	)	)	PUNCT
fnp-3806	473	25	.	.	PUNCT
fnp-3806	474	1	α1	α1	PROPN
fnp-3806	474	2	and	and	CCONJ
fnp-3806	474	3	α5	α5	ADJ
fnp-3806	474	4	subunit	subunit	NOUN
fnp-3806	474	5	protein	protein	NOUN
fnp-3806	474	6	-	-	PUNCT
fnp-3806	474	7	immunoreactive	immunoreactive	ADJ
fnp-3806	474	8	levels	level	NOUN
fnp-3806	474	9	are	be	AUX
fnp-3806	474	10	decreased	decrease	VERB
fnp-3806	474	11	in	in	ADP
fnp-3806	474	12	the	the	DET
fnp-3806	474	13	ca1	ca1	PROPN
fnp-3806	474	14	region	region	NOUN
fnp-3806	474	15	of	of	ADP
fnp-3806	474	16	the	the	DET
fnp-3806	474	17	hippocampus	hippocampus	NOUN
fnp-3806	474	18	(	(	PUNCT
fnp-3806	474	19	521	521	NUM
fnp-3806	474	20	-	-	NUM
fnp-3806	474	21	524	524	NUM
fnp-3806	474	22	)	)	PUNCT
fnp-3806	474	23	,	,	PUNCT
fnp-3806	474	24	whereas	whereas	SCONJ
fnp-3806	474	25	α3	α3	PROPN
fnp-3806	474	26	,	,	PUNCT
fnp-3806	474	27	β1	β1	PROPN
fnp-3806	474	28	,	,	PUNCT
fnp-3806	474	29	β2	β2	NOUN
fnp-3806	474	30	,	,	PUNCT
fnp-3806	474	31	β3	β3	VERB
fnp-3806	474	32	,	,	PUNCT
fnp-3806	474	33	and	and	CCONJ
fnp-3806	474	34	γ2	γ2	ADJ
fnp-3806	474	35	subunits	subunit	NOUN
fnp-3806	474	36	are	be	AUX
fnp-3806	474	37	unaffected	unaffected	ADJ
fnp-3806	474	38	.	.	PUNCT
fnp-3806	475	1	in	in	ADP
fnp-3806	475	2	contrast	contrast	NOUN
fnp-3806	475	3	,	,	PUNCT
fnp-3806	475	4	α1	α1	PROPN
fnp-3806	475	5	subunits	subunit	NOUN
fnp-3806	475	6	are	be	AUX
fnp-3806	475	7	increased	increase	VERB
fnp-3806	475	8	in	in	ADP
fnp-3806	475	9	the	the	DET
fnp-3806	475	10	ca3	ca3	NOUN
fnp-3806	475	11	region	region	NOUN
fnp-3806	475	12	,	,	PUNCT
fnp-3806	475	13	granule	granule	NOUN
fnp-3806	475	14	cell	cell	NOUN
fnp-3806	475	15	layer	layer	NOUN
fnp-3806	475	16	,	,	PUNCT
fnp-3806	475	17	and	and	CCONJ
fnp-3806	475	18	hilus	hilus	NOUN
fnp-3806	475	19	of	of	ADP
fnp-3806	475	20	the	the	DET
fnp-3806	475	21	dentate	dentate	ADJ
fnp-3806	475	22	gyrus	gyrus	NOUN
fnp-3806	475	23	in	in	ADP
fnp-3806	475	24	sad	sad	ADJ
fnp-3806	475	25	(	(	PUNCT
fnp-3806	475	26	523	523	NUM
fnp-3806	475	27	-	-	SYM
fnp-3806	475	28	527	527	NUM
fnp-3806	475	29	)	)	PUNCT
fnp-3806	475	30	.	.	PUNCT
fnp-3806	476	1	β3	β3	VERB
fnp-3806	476	2	subunit	subunit	NOUN
fnp-3806	476	3	expression	expression	NOUN
fnp-3806	476	4	is	be	AUX
fnp-3806	476	5	decreased	decrease	VERB
fnp-3806	476	6	in	in	ADP
fnp-3806	476	7	the	the	DET
fnp-3806	476	8	stratum	stratum	NOUN
fnp-3806	476	9	oriens	orien	NOUN
fnp-3806	476	10	,	,	PUNCT
fnp-3806	476	11	radiatum	radiatum	NOUN
fnp-3806	476	12	of	of	ADP
fnp-3806	476	13	ca2	ca2	PROPN
fnp-3806	476	14	and	and	CCONJ
fnp-3806	476	15	ca3	ca3	PROPN
fnp-3806	476	16	,	,	PUNCT
fnp-3806	476	17	and	and	CCONJ
fnp-3806	476	18	stratum	stratum	PROPN
fnp-3806	476	19	moleculare	moleculare	VERB
fnp-3806	476	20	(	(	PUNCT
fnp-3806	476	21	527	527	NUM
fnp-3806	476	22	)	)	PUNCT
fnp-3806	476	23	,	,	PUNCT
fnp-3806	476	24	whereas	whereas	SCONJ
fnp-3806	476	25	γ1/3	γ1/3	NOUN
fnp-3806	476	26	subunits	subunit	NOUN
fnp-3806	476	27	are	be	AUX
fnp-3806	476	28	upregulated	upregulate	VERB
fnp-3806	476	29	in	in	ADP
fnp-3806	476	30	the	the	DET
fnp-3806	476	31	hippocampus	hippocampus	NOUN
fnp-3806	476	32	in	in	ADP
fnp-3806	476	33	sad	sad	ADJ
fnp-3806	476	34	(	(	PUNCT
fnp-3806	476	35	525	525	NUM
fnp-3806	476	36	,	,	PUNCT
fnp-3806	476	37	527	527	NUM
fnp-3806	476	38	)	)	PUNCT
fnp-3806	476	39	.	.	PUNCT
fnp-3806	477	1	aβ	aβ	PRON
fnp-3806	477	2	induces	induce	VERB
fnp-3806	477	3	the	the	DET
fnp-3806	477	4	downregulation	downregulation	NOUN
fnp-3806	477	5	of	of	ADP
fnp-3806	477	6	gabaa	gabaa	NOUN
fnp-3806	477	7	receptors	receptor	NOUN
fnp-3806	477	8	,	,	PUNCT
fnp-3806	477	9	inhibitory	inhibitory	ADJ
fnp-3806	477	10	dysfunction	dysfunction	NOUN
fnp-3806	477	11	,	,	PUNCT
fnp-3806	477	12	and	and	CCONJ
fnp-3806	477	13	sprouting	sprout	VERB
fnp-3806	477	14	of	of	ADP
fnp-3806	477	15	gabaergic	gabaergic	ADJ
fnp-3806	477	16	axons	axon	NOUN
fnp-3806	477	17	(	(	PUNCT
fnp-3806	477	18	528	528	NUM
fnp-3806	477	19	-	-	SYM
fnp-3806	477	20	532	532	NUM
fnp-3806	477	21	)	)	PUNCT
fnp-3806	477	22	.	.	PUNCT
fnp-3806	478	1	7d	7d	NUM
fnp-3806	478	2	.	.	PUNCT
fnp-3806	478	3	serotonin	serotonin	VERB
fnp-3806	478	4	and	and	CCONJ
fnp-3806	478	5	5	5	NUM
fnp-3806	478	6	-	-	PUNCT
fnp-3806	478	7	hydroxytryptamine	hydroxytryptamine	NOUN
fnp-3806	478	8	(	(	PUNCT
fnp-3806	478	9	5	5	NUM
fnp-3806	478	10	-	-	PUNCT
fnp-3806	478	11	ht	ht	NOUN
fnp-3806	478	12	)	)	PUNCT
fnp-3806	478	13	receptors	receptor	NOUN
fnp-3806	478	14	5	5	NUM
fnp-3806	478	15	-	-	PUNCT
fnp-3806	478	16	hydroxytryptamine	hydroxytryptamine	NOUN
fnp-3806	478	17	(	(	PUNCT
fnp-3806	478	18	5	5	NUM
fnp-3806	478	19	-	-	SYM
fnp-3806	478	20	ht	ht	NOUN
fnp-3806	478	21	)	)	PUNCT
fnp-3806	478	22	derives	derive	VERB
fnp-3806	478	23	from	from	ADP
fnp-3806	478	24	the	the	DET
fnp-3806	478	25	amino	amino	NOUN
fnp-3806	478	26	acid	acid	NOUN
fnp-3806	478	27	tryptophan	tryptophan	NOUN
fnp-3806	478	28	via	via	ADP
fnp-3806	478	29	the	the	DET
fnp-3806	478	30	intermediate	intermediate	ADJ
fnp-3806	478	31	5	5	NUM
fnp-3806	478	32	-	-	PUNCT
fnp-3806	478	33	hydroxytryptophan	hydroxytryptophan	NOUN
fnp-3806	478	34	and	and	CCONJ
fnp-3806	478	35	decarboxylation	decarboxylation	NOUN
fnp-3806	478	36	to	to	PART
fnp-3806	478	37	form	form	VERB
fnp-3806	478	38	serotonin	serotonin	NOUN
fnp-3806	478	39	.	.	PUNCT
fnp-3806	479	1	in	in	ADP
fnp-3806	479	2	the	the	DET
fnp-3806	479	3	brain	brain	NOUN
fnp-3806	479	4	,	,	PUNCT
fnp-3806	479	5	5	5	NUM
fnp-3806	479	6	-	-	SYM
fnp-3806	479	7	ht	ht	PROPN
fnp-3806	479	8	is	be	AUX
fnp-3806	479	9	mainly	mainly	ADV
fnp-3806	479	10	produced	produce	VERB
fnp-3806	479	11	in	in	ADP
fnp-3806	479	12	the	the	DET
fnp-3806	479	13	raphe	raphe	NOUN
fnp-3806	479	14	nuclei	nucleus	NOUN
fnp-3806	479	15	of	of	ADP
fnp-3806	479	16	the	the	DET
fnp-3806	479	17	brain	brain	NOUN
fnp-3806	479	18	stem	stem	NOUN
fnp-3806	479	19	that	that	PRON
fnp-3806	479	20	constitutes	constitute	VERB
fnp-3806	479	21	part	part	NOUN
fnp-3806	479	22	of	of	ADP
fnp-3806	479	23	the	the	DET
fnp-3806	479	24	reticular	reticular	ADJ
fnp-3806	479	25	formation	formation	NOUN
fnp-3806	479	26	.	.	PUNCT
fnp-3806	480	1	ascending	ascend	VERB
fnp-3806	480	2	serotoninergic	serotoninergic	ADJ
fnp-3806	480	3	fibres	fibre	NOUN
fnp-3806	480	4	innervate	innervate	VERB
fnp-3806	480	5	the	the	DET
fnp-3806	480	6	whole	whole	ADJ
fnp-3806	480	7	telencephalon	telencephalon	NOUN
fnp-3806	480	8	.	.	PUNCT
fnp-3806	481	1	descending	descend	VERB
fnp-3806	481	2	projections	projection	NOUN
fnp-3806	481	3	innervate	innervate	VERB
fnp-3806	481	4	the	the	DET
fnp-3806	481	5	cerebellum	cerebellum	NOUN
fnp-3806	481	6	and	and	CCONJ
fnp-3806	481	7	the	the	DET
fnp-3806	481	8	spinal	spinal	ADJ
fnp-3806	481	9	cord	cord	NOUN
fnp-3806	481	10	(	(	PUNCT
fnp-3806	481	11	443	443	NUM
fnp-3806	481	12	)	)	PUNCT
fnp-3806	481	13	.	.	PUNCT
fnp-3806	482	1	serotonin	serotonin	NOUN
fnp-3806	482	2	is	be	AUX
fnp-3806	482	3	stored	store	VERB
fnp-3806	482	4	at	at	ADP
fnp-3806	482	5	the	the	DET
fnp-3806	482	6	synaptic	synaptic	ADJ
fnp-3806	482	7	vesicles	vesicle	NOUN
fnp-3806	482	8	and	and	CCONJ
fnp-3806	482	9	released	release	VERB
fnp-3806	482	10	into	into	ADP
fnp-3806	482	11	the	the	DET
fnp-3806	482	12	synapse	synapse	NOUN
fnp-3806	482	13	,	,	PUNCT
fnp-3806	482	14	where	where	SCONJ
fnp-3806	482	15	it	it	PRON
fnp-3806	482	16	binds	bind	VERB
fnp-3806	482	17	to	to	PART
fnp-3806	482	18	post	post	ADJ
fnp-3806	482	19	-	-	ADJ
fnp-3806	482	20	synaptic	synaptic	ADJ
fnp-3806	482	21	and	and	CCONJ
fnp-3806	482	22	auto	auto	NOUN
fnp-3806	482	23	-	-	PUNCT
fnp-3806	482	24	pre	pre	ADJ
fnp-3806	482	25	-	-	ADJ
fnp-3806	482	26	synaptic	synaptic	ADJ
fnp-3806	482	27	receptors	receptor	NOUN
fnp-3806	482	28	.	.	PUNCT
fnp-3806	483	1	serotonin	serotonin	NOUN
fnp-3806	483	2	is	be	AUX
fnp-3806	483	3	then	then	ADV
fnp-3806	483	4	re	re	VERB
fnp-3806	483	5	-	-	VERB
fnp-3806	483	6	uptaken	uptaken	ADJ
fnp-3806	483	7	via	via	ADP
fnp-3806	483	8	serotonin	serotonin	NOUN
fnp-3806	483	9	transporters	transporter	NOUN
fnp-3806	483	10	and	and	CCONJ
fnp-3806	483	11	reused	reuse	VERB
fnp-3806	483	12	or	or	CCONJ
fnp-3806	483	13	degraded	degrade	VERB
fnp-3806	483	14	by	by	ADP
fnp-3806	483	15	monoamine	monoamine	ADJ
fnp-3806	483	16	oxidase	oxidase	NOUN
fnp-3806	483	17	.	.	PUNCT
fnp-3806	484	1	5	5	NUM
fnp-3806	484	2	-	-	PUNCT
fnp-3806	484	3	ht	ht	NOUN
fnp-3806	484	4	receptors	receptor	NOUN
fnp-3806	484	5	are	be	AUX
fnp-3806	484	6	categorized	categorize	VERB
fnp-3806	484	7	into	into	ADP
fnp-3806	484	8	metabotropic	metabotropic	NOUN
fnp-3806	484	9	and	and	CCONJ
fnp-3806	484	10	ionotropic	ionotropic	ADJ
fnp-3806	484	11	receptors	receptor	NOUN
fnp-3806	484	12	.	.	PUNCT
fnp-3806	485	1	metabotropic	metabotropic	NOUN
fnp-3806	485	2	gpcr	gpcr	ADJ
fnp-3806	485	3	are	be	AUX
fnp-3806	485	4	5	5	NUM
fnp-3806	485	5	-	-	PUNCT
fnp-3806	485	6	ht1	ht1	ADJ
fnp-3806	485	7	,	,	PUNCT
fnp-3806	485	8	5	5	NUM
fnp-3806	485	9	-	-	PUNCT
fnp-3806	485	10	ht2	ht2	NOUN
fnp-3806	485	11	,	,	PUNCT
fnp-3806	485	12	5	5	NUM
fnp-3806	485	13	-	-	PUNCT
fnp-3806	485	14	ht4	ht4	ADJ
fnp-3806	485	15	,	,	PUNCT
fnp-3806	485	16	5	5	NUM
fnp-3806	485	17	-	-	PUNCT
fnp-3806	485	18	ht5	ht5	ADJ
fnp-3806	485	19	,	,	PUNCT
fnp-3806	485	20	5	5	NUM
fnp-3806	485	21	-	-	NUM
fnp-3806	485	22	ht6	ht6	NOUN
fnp-3806	485	23	,	,	PUNCT
fnp-3806	485	24	and	and	CCONJ
fnp-3806	485	25	5	5	NUM
fnp-3806	485	26	-	-	PUNCT
fnp-3806	485	27	ht7	ht7	NOUN
fnp-3806	485	28	.	.	PUNCT
fnp-3806	486	1	the	the	DET
fnp-3806	486	2	only	only	ADJ
fnp-3806	486	3	ionotropic	ionotropic	ADJ
fnp-3806	486	4	receptor	receptor	NOUN
fnp-3806	486	5	is	be	AUX
fnp-3806	486	6	5	5	NUM
fnp-3806	486	7	-	-	PUNCT
fnp-3806	486	8	ht3	ht3	NOUN
fnp-3806	486	9	,	,	PUNCT
fnp-3806	486	10	permeable	permeable	ADJ
fnp-3806	486	11	to	to	ADP
fnp-3806	486	12	sodium	sodium	NOUN
fnp-3806	486	13	,	,	PUNCT
fnp-3806	486	14	potassium	potassium	NOUN
fnp-3806	486	15	,	,	PUNCT
fnp-3806	486	16	and	and	CCONJ
fnp-3806	486	17	calcium	calcium	NOUN
fnp-3806	486	18	ions	ion	NOUN
fnp-3806	486	19	.	.	PUNCT
fnp-3806	487	1	5	5	NUM
fnp-3806	487	2	-	-	NUM
fnp-3806	487	3	ht1	ht1	NOUN
fnp-3806	487	4	and	and	CCONJ
fnp-3806	487	5	5	5	NUM
fnp-3806	487	6	-	-	PUNCT
fnp-3806	487	7	ht5	ht5	NOUN
fnp-3806	487	8	receptors	receptor	NOUN
fnp-3806	487	9	bind	bind	VERB
fnp-3806	487	10	to	to	ADP
fnp-3806	487	11	gαi	gαi	PROPN
fnp-3806	487	12	/	/	SYM
fnp-3806	487	13	o	o	NOUN
fnp-3806	487	14	proteins	protein	NOUN
fnp-3806	487	15	,	,	PUNCT
fnp-3806	487	16	inhibit	inhibit	NOUN
fnp-3806	487	17	ac	ac	PROPN
fnp-3806	487	18	,	,	PUNCT
fnp-3806	487	19	and	and	CCONJ
fnp-3806	487	20	decrease	decrease	VERB
fnp-3806	487	21	camp	camp	NOUN
fnp-3806	487	22	levels	level	NOUN
fnp-3806	487	23	.	.	PUNCT
fnp-3806	488	1	5	5	NUM
fnp-3806	488	2	-	-	PUNCT
fnp-3806	488	3	ht2	ht2	NOUN
fnp-3806	488	4	receptors	receptor	NOUN
fnp-3806	488	5	bind	bind	VERB
fnp-3806	488	6	with	with	ADP
fnp-3806	488	7	gαq/11	gαq/11	NOUN
fnp-3806	488	8	,	,	PUNCT
fnp-3806	488	9	activate	activate	VERB
fnp-3806	488	10	plc	plc	PROPN
fnp-3806	488	11	,	,	PUNCT
fnp-3806	488	12	generate	generate	VERB
fnp-3806	488	13	pi3p	pi3p	ADJ
fnp-3806	488	14	,	,	PUNCT
fnp-3806	488	15	and	and	CCONJ
fnp-3806	488	16	activate	activate	VERB
fnp-3806	488	17	pkc	pkc	PROPN
fnp-3806	488	18	(	(	PUNCT
fnp-3806	488	19	533	533	NUM
fnp-3806	488	20	-	-	SYM
fnp-3806	488	21	541	541	NUM
fnp-3806	488	22	)	)	PUNCT
fnp-3806	488	23	.	.	PUNCT
fnp-3806	489	1	5	5	NUM
fnp-3806	489	2	-	-	SYM
fnp-3806	489	3	ht	ht	NOUN
fnp-3806	489	4	and	and	CCONJ
fnp-3806	489	5	receptors	receptor	NOUN
fnp-3806	489	6	interact	interact	VERB
fnp-3806	489	7	with	with	ADP
fnp-3806	489	8	the	the	DET
fnp-3806	489	9	cholinergic	cholinergic	ADJ
fnp-3806	489	10	,	,	PUNCT
fnp-3806	489	11	glutamatergic	glutamatergic	ADJ
fnp-3806	489	12	,	,	PUNCT
fnp-3806	489	13	noradrenergic	noradrenergic	ADJ
fnp-3806	489	14	,	,	PUNCT
fnp-3806	489	15	gabaergic	gabaergic	ADJ
fnp-3806	489	16	,	,	PUNCT
fnp-3806	489	17	endocannabinoid	endocannabinoid	NOUN
fnp-3806	489	18	,	,	PUNCT
fnp-3806	489	19	and	and	CCONJ
fnp-3806	489	20	glial	glial	ADJ
fnp-3806	489	21	cell	cell	NOUN
fnp-3806	489	22	systems	system	NOUN
fnp-3806	489	23	(	(	PUNCT
fnp-3806	489	24	542	542	NUM
fnp-3806	489	25	-	-	SYM
fnp-3806	489	26	545	545	NUM
fnp-3806	489	27	)	)	PUNCT
fnp-3806	489	28	.	.	PUNCT
fnp-3806	490	1	orexins	orexin	NOUN
fnp-3806	490	2	regulate	regulate	VERB
fnp-3806	490	3	serotonin	serotonin	NOUN
fnp-3806	490	4	neurons	neuron	NOUN
fnp-3806	490	5	in	in	ADP
fnp-3806	490	6	the	the	DET
fnp-3806	490	7	raphe	raphe	NOUN
fnp-3806	490	8	nucleus	nucleus	NOUN
fnp-3806	490	9	(	(	PUNCT
fnp-3806	490	10	546	546	NUM
fnp-3806	490	11	)	)	PUNCT
fnp-3806	490	12	.	.	PUNCT
fnp-3806	491	1	the	the	DET
fnp-3806	491	2	serotoninergic	serotoninergic	ADJ
fnp-3806	491	3	system	system	NOUN
fnp-3806	491	4	is	be	AUX
fnp-3806	491	5	altered	alter	VERB
fnp-3806	491	6	in	in	ADP
fnp-3806	491	7	aging	age	VERB
fnp-3806	491	8	and	and	CCONJ
fnp-3806	491	9	sad	sad	ADJ
fnp-3806	491	10	(	(	PUNCT
fnp-3806	491	11	443	443	NUM
fnp-3806	491	12	,	,	PUNCT
fnp-3806	491	13	547	547	NUM
fnp-3806	491	14	-	-	SYM
fnp-3806	491	15	549	549	NUM
fnp-3806	491	16	)	)	PUNCT
fnp-3806	491	17	.	.	PUNCT
fnp-3806	492	1	the	the	DET
fnp-3806	492	2	main	main	ADJ
fnp-3806	492	3	alteration	alteration	NOUN
fnp-3806	492	4	of	of	ADP
fnp-3806	492	5	the	the	DET
fnp-3806	492	6	serotoninergic	serotoninergic	ADJ
fnp-3806	492	7	system	system	NOUN
fnp-3806	492	8	in	in	ADP
fnp-3806	492	9	brain	brain	NOUN
fnp-3806	492	10	aging	aging	NOUN
fnp-3806	492	11	and	and	CCONJ
fnp-3806	492	12	sad	sad	ADJ
fnp-3806	492	13	results	result	NOUN
fnp-3806	492	14	from	from	ADP
fnp-3806	492	15	neuronal	neuronal	ADJ
fnp-3806	492	16	damage	damage	NOUN
fnp-3806	492	17	and	and	CCONJ
fnp-3806	492	18	nft	nft	PROPN
fnp-3806	492	19	formation	formation	NOUN
fnp-3806	492	20	in	in	ADP
fnp-3806	492	21	the	the	DET
fnp-3806	492	22	raphe	raphe	NOUN
fnp-3806	492	23	nuclei	nucleus	NOUN
fnp-3806	492	24	in	in	ADP
fnp-3806	492	25	the	the	DET
fnp-3806	492	26	independent	independent	ADJ
fnp-3806	492	27	origin	origin	NOUN
fnp-3806	492	28	of	of	ADP
fnp-3806	492	29	nft	nft	PROPN
fnp-3806	492	30	pathology	pathology	PROPN
fnp-3806	492	31	at	at	ADP
fnp-3806	492	32	early	early	ADJ
fnp-3806	492	33	stages	stage	NOUN
fnp-3806	492	34	of	of	ADP
fnp-3806	492	35	ad	ad	NOUN
fnp-3806	492	36	-	-	PUNCT
fnp-3806	492	37	related	relate	VERB
fnp-3806	492	38	pathology	pathology	NOUN
fnp-3806	492	39	.	.	PUNCT
fnp-3806	493	1	damage	damage	NOUN
fnp-3806	493	2	to	to	ADP
fnp-3806	493	3	the	the	DET
fnp-3806	493	4	serotoninergic	serotoninergic	ADJ
fnp-3806	493	5	system	system	NOUN
fnp-3806	493	6	contributes	contribute	VERB
fnp-3806	493	7	to	to	ADP
fnp-3806	493	8	mood	mood	NOUN
fnp-3806	493	9	changes	change	NOUN
fnp-3806	493	10	and	and	CCONJ
fnp-3806	493	11	depression	depression	NOUN
fnp-3806	493	12	which	which	PRON
fnp-3806	493	13	are	be	AUX
fnp-3806	493	14	characteristic	characteristic	ADJ
fnp-3806	493	15	non	non	ADJ
fnp-3806	493	16	-	-	ADJ
fnp-3806	493	17	cognitive	cognitive	ADJ
fnp-3806	493	18	clinical	clinical	ADJ
fnp-3806	493	19	manifestations	manifestation	NOUN
fnp-3806	493	20	of	of	ADP
fnp-3806	493	21	brain	brain	NOUN
fnp-3806	493	22	aging	aging	NOUN
fnp-3806	493	23	and	and	CCONJ
fnp-3806	493	24	sad	sad	ADJ
fnp-3806	493	25	(	(	PUNCT
fnp-3806	493	26	443	443	NUM
fnp-3806	493	27	,	,	PUNCT
fnp-3806	493	28	550	550	NUM
fnp-3806	493	29	-	-	SYM
fnp-3806	493	30	553	553	NUM
fnp-3806	493	31	)	)	PUNCT
fnp-3806	493	32	.	.	PUNCT
fnp-3806	494	1	serotonin	serotonin	NOUN
fnp-3806	494	2	is	be	AUX
fnp-3806	494	3	linked	link	VERB
fnp-3806	494	4	to	to	PART
fnp-3806	494	5	decreased	decrease	VERB
fnp-3806	494	6	β	β	NOUN
fnp-3806	494	7	-	-	ADJ
fnp-3806	494	8	amyloid	amyloid	ADJ
fnp-3806	494	9	production	production	NOUN
fnp-3806	494	10	and	and	CCONJ
fnp-3806	494	11	modulation	modulation	NOUN
fnp-3806	494	12	of	of	ADP
fnp-3806	494	13	soluble	soluble	ADJ
fnp-3806	494	14	β	β	NOUN
fnp-3806	494	15	-	-	ADJ
fnp-3806	494	16	amyloid	amyloid	ADJ
fnp-3806	494	17	precursor	precursor	NOUN
fnp-3806	494	18	protein	protein	NOUN
fnp-3806	494	19	(	(	PUNCT
fnp-3806	494	20	sappβ	sappβ	ADV
fnp-3806	494	21	)	)	PUNCT
fnp-3806	494	22	(	(	PUNCT
fnp-3806	494	23	554	554	NUM
fnp-3806	494	24	-	-	NUM
fnp-3806	494	25	557	557	NUM
fnp-3806	494	26	)	)	PUNCT
fnp-3806	494	27	.	.	PUNCT
fnp-3806	495	1	in	in	ADP
fnp-3806	495	2	addition	addition	NOUN
fnp-3806	495	3	,	,	PUNCT
fnp-3806	495	4	5	5	NUM
fnp-3806	495	5	-	-	PUNCT
fnp-3806	495	6	ht4	ht4	NOUN
fnp-3806	495	7	receptors	receptor	NOUN
fnp-3806	495	8	inhibit	inhibit	VERB
fnp-3806	495	9	the	the	DET
fnp-3806	495	10	secretion	secretion	NOUN
fnp-3806	495	11	of	of	ADP
fnp-3806	495	12	β	β	NOUN
fnp-3806	495	13	-	-	ADJ
fnp-3806	495	14	amyloid	amyloid	ADJ
fnp-3806	495	15	peptides	peptide	NOUN
fnp-3806	495	16	(	(	PUNCT
fnp-3806	495	17	558	558	NUM
fnp-3806	495	18	-	-	SYM
fnp-3806	495	19	560	560	NUM
fnp-3806	495	20	)	)	PUNCT
fnp-3806	495	21	.	.	PUNCT
fnp-3806	496	1	due	due	ADP
fnp-3806	496	2	to	to	ADP
fnp-3806	496	3	the	the	DET
fnp-3806	496	4	multiple	multiple	ADJ
fnp-3806	496	5	facets	facet	NOUN
fnp-3806	496	6	of	of	ADP
fnp-3806	496	7	serotonin	serotonin	NOUN
fnp-3806	496	8	,	,	PUNCT
fnp-3806	496	9	serotonin	serotonin	NOUN
fnp-3806	496	10	receptors	receptor	NOUN
fnp-3806	496	11	,	,	PUNCT
fnp-3806	496	12	and	and	CCONJ
fnp-3806	496	13	their	their	PRON
fnp-3806	496	14	interaction	interaction	NOUN
fnp-3806	496	15	with	with	ADP
fnp-3806	496	16	other	other	ADJ
fnp-3806	496	17	neurotransmitters	neurotransmitter	NOUN
fnp-3806	496	18	,	,	PUNCT
fnp-3806	496	19	agonists	agonist	NOUN
fnp-3806	496	20	,	,	PUNCT
fnp-3806	496	21	antagonists	antagonist	NOUN
fnp-3806	496	22	of	of	ADP
fnp-3806	496	23	the	the	DET
fnp-3806	496	24	different	different	ADJ
fnp-3806	496	25	5	5	NUM
fnp-3806	496	26	-	-	PUNCT
fnp-3806	496	27	ht	ht	NOUN
fnp-3806	496	28	receptors	receptor	NOUN
fnp-3806	496	29	,	,	PUNCT
fnp-3806	496	30	and	and	CCONJ
fnp-3806	496	31	principally	principally	ADV
fnp-3806	496	32	selective	selective	ADJ
fnp-3806	496	33	serotonin	serotonin	NOUN
fnp-3806	496	34	re	re	NOUN
fnp-3806	496	35	-	-	ADJ
fnp-3806	496	36	uptake	uptake	ADJ
fnp-3806	496	37	inhibitors	inhibitor	NOUN
fnp-3806	496	38	are	be	AUX
fnp-3806	496	39	useful	useful	ADJ
fnp-3806	496	40	pharmacological	pharmacological	ADJ
fnp-3806	496	41	agents	agent	NOUN
fnp-3806	496	42	to	to	PART
fnp-3806	496	43	improve	improve	VERB
fnp-3806	496	44	cognition	cognition	NOUN
fnp-3806	496	45	and	and	CCONJ
fnp-3806	496	46	reduce	reduce	VERB
fnp-3806	496	47	depression	depression	NOUN
fnp-3806	496	48	in	in	ADP
fnp-3806	496	49	aging	age	VERB
fnp-3806	496	50	and	and	CCONJ
fnp-3806	496	51	sad	sad	ADJ
fnp-3806	496	52	(	(	PUNCT
fnp-3806	496	53	444	444	NUM
fnp-3806	496	54	,	,	PUNCT
fnp-3806	496	55	552	552	NUM
fnp-3806	496	56	,	,	PUNCT
fnp-3806	496	57	561	561	NUM
fnp-3806	496	58	-	-	SYM
fnp-3806	496	59	568	568	NUM
fnp-3806	496	60	)	)	PUNCT
fnp-3806	496	61	.	.	PUNCT
fnp-3806	497	1	7e	7e	NUM
fnp-3806	497	2	.	.	PUNCT
fnp-3806	498	1	noradrenergic	noradrenergic	ADJ
fnp-3806	498	2	system	system	NOUN
fnp-3806	498	3	norepinephrine	norepinephrine	NOUN
fnp-3806	498	4	or	or	CCONJ
fnp-3806	498	5	noradrenaline	noradrenaline	NOUN
fnp-3806	498	6	is	be	AUX
fnp-3806	498	7	synthesized	synthesize	VERB
fnp-3806	498	8	from	from	ADP
fnp-3806	498	9	dopamine	dopamine	NOUN
fnp-3806	498	10	by	by	ADP
fnp-3806	498	11	the	the	DET
fnp-3806	498	12	enzyme	enzyme	NOUN
fnp-3806	498	13	dopamine	dopamine	NOUN
fnp-3806	498	14	β	β	NOUN
fnp-3806	498	15	-	-	NOUN
fnp-3806	498	16	hydroxylase	hydroxylase	ADJ
fnp-3806	498	17	(	(	PUNCT
fnp-3806	498	18	dbh	dbh	PROPN
fnp-3806	498	19	)	)	PUNCT
fnp-3806	498	20	.	.	PUNCT
fnp-3806	499	1	norepinephrine	norepinephrine	NOUN
fnp-3806	499	2	is	be	AUX
fnp-3806	499	3	metabolized	metabolize	VERB
fnp-3806	499	4	by	by	ADP
fnp-3806	499	5	mono	mono	NOUN
fnp-3806	499	6	-	-	PUNCT
fnp-3806	499	7	amino	amino	NOUN
fnp-3806	499	8	oxidase	oxidase	NOUN
fnp-3806	499	9	(	(	PUNCT
fnp-3806	499	10	mao	mao	PROPN
fnp-3806	499	11	)	)	PUNCT
fnp-3806	499	12	and	and	CCONJ
fnp-3806	500	1	catechol	catechol	NOUN
fnp-3806	500	2	-	-	PUNCT
fnp-3806	500	3	o	o	NOUN
fnp-3806	500	4	-	-	NOUN
fnp-3806	500	5	methyltransferase	methyltransferase	NOUN
fnp-3806	500	6	(	(	PUNCT
fnp-3806	500	7	comt	comt	PROPN
fnp-3806	500	8	)	)	PUNCT
fnp-3806	500	9	.	.	PUNCT
fnp-3806	501	1	norepinephrine	norepinephrine	NOUN
fnp-3806	501	2	is	be	AUX
fnp-3806	501	3	transported	transport	VERB
fnp-3806	501	4	from	from	ADP
fnp-3806	501	5	the	the	DET
fnp-3806	501	6	cytosol	cytosol	NOUN
fnp-3806	501	7	to	to	ADP
fnp-3806	501	8	the	the	DET
fnp-3806	501	9	synaptic	synaptic	ADJ
fnp-3806	501	10	vesicles	vesicle	NOUN
fnp-3806	501	11	by	by	ADP
fnp-3806	501	12	the	the	DET
fnp-3806	501	13	vesicular	vesicular	ADJ
fnp-3806	501	14	monoamino	monoamino	NOUN
fnp-3806	501	15	transporter	transporter	NOUN
fnp-3806	501	16	(	(	PUNCT
fnp-3806	501	17	vmat	vmat	NOUN
fnp-3806	501	18	)	)	PUNCT
fnp-3806	501	19	(	(	PUNCT
fnp-3806	501	20	569	569	NUM
fnp-3806	501	21	,	,	PUNCT
fnp-3806	501	22	570	570	NUM
fnp-3806	501	23	)	)	PUNCT
fnp-3806	501	24	.	.	PUNCT
fnp-3806	502	1	norepinephrine	norepinephrine	NOUN
fnp-3806	502	2	can	can	AUX
fnp-3806	502	3	bind	bind	VERB
fnp-3806	502	4	both	both	PRON
fnp-3806	502	5	to	to	PART
fnp-3806	502	6	metabotropic	metabotropic	VERB
fnp-3806	502	7	preand	preand	NOUN
fnp-3806	502	8	post	post	ADJ
fnp-3806	502	9	-	-	ADJ
fnp-3806	502	10	synaptic	synaptic	ADJ
fnp-3806	502	11	α1	α1	NOUN
fnp-3806	502	12	,	,	PUNCT
fnp-3806	502	13	α2	α2	ADJ
fnp-3806	502	14	,	,	PUNCT
fnp-3806	502	15	β1	β1	PROPN
fnp-3806	502	16	,	,	PUNCT
fnp-3806	502	17	β2	β2	NOUN
fnp-3806	502	18	,	,	PUNCT
fnp-3806	502	19	and	and	CCONJ
fnp-3806	502	20	β3	β3	ADJ
fnp-3806	502	21	receptors	receptor	NOUN
fnp-3806	502	22	.	.	PUNCT
fnp-3806	503	1	α1	α1	PROPN
fnp-3806	503	2	are	be	AUX
fnp-3806	503	3	gq	gq	NOUN
fnp-3806	503	4	-	-	PUNCT
fnp-3806	503	5	coupled	couple	VERB
fnp-3806	503	6	and	and	CCONJ
fnp-3806	503	7	activate	activate	VERB
fnp-3806	503	8	plc	plc	PROPN
fnp-3806	503	9	;	;	PUNCT
fnp-3806	503	10	α2	α2	PROPN
fnp-3806	503	11	are	be	AUX
fnp-3806	503	12	coupled	couple	VERB
fnp-3806	503	13	to	to	PART
fnp-3806	503	14	gi	gi	VERB
fnp-3806	503	15	/	/	SYM
fnp-3806	503	16	g0	g0	ADJ
fnp-3806	503	17	proteins	protein	NOUN
fnp-3806	503	18	and	and	CCONJ
fnp-3806	503	19	inhibit	inhibit	VERB
fnp-3806	503	20	ac	ac	PROPN
fnp-3806	503	21	;	;	PUNCT
fnp-3806	503	22	β1	β1	PROPN
fnp-3806	503	23	,	,	PUNCT
fnp-3806	503	24	β2	β2	NOUN
fnp-3806	503	25	,	,	PUNCT
fnp-3806	503	26	and	and	CCONJ
fnp-3806	503	27	β3	β3	NOUN
fnp-3806	503	28	are	be	AUX
fnp-3806	503	29	coupled	couple	VERB
fnp-3806	503	30	to	to	ADP
fnp-3806	503	31	gs	gs	PROPN
fnp-3806	503	32	proteins	protein	NOUN
fnp-3806	503	33	and	and	CCONJ
fnp-3806	503	34	activate	activate	VERB
fnp-3806	503	35	ac	ac	PROPN
fnp-3806	503	36	(	(	PUNCT
fnp-3806	503	37	571	571	NUM
fnp-3806	503	38	-	-	SYM
fnp-3806	503	39	574	574	NUM
fnp-3806	503	40	)	)	PUNCT
fnp-3806	503	41	.	.	PUNCT
fnp-3806	504	1	the	the	DET
fnp-3806	504	2	locus	locus	NOUN
fnp-3806	504	3	coeruleus	coeruleus	NOUN
fnp-3806	504	4	,	,	PUNCT
fnp-3806	504	5	which	which	PRON
fnp-3806	504	6	contains	contain	VERB
fnp-3806	504	7	about	about	ADP
fnp-3806	504	8	15,000	15,000	NUM
fnp-3806	504	9	neurons	neuron	NOUN
fnp-3806	504	10	in	in	ADP
fnp-3806	504	11	primates	primate	NOUN
fnp-3806	504	12	,	,	PUNCT
fnp-3806	504	13	is	be	AUX
fnp-3806	504	14	the	the	DET
fnp-3806	504	15	principal	principal	ADJ
fnp-3806	504	16	source	source	NOUN
fnp-3806	504	17	of	of	ADP
fnp-3806	504	18	brain	brain	NOUN
fnp-3806	504	19	noradrenaline	noradrenaline	NOUN
fnp-3806	504	20	.	.	PUNCT
fnp-3806	505	1	noradrenergic	noradrenergic	ADJ
fnp-3806	505	2	terminals	terminal	NOUN
fnp-3806	505	3	innervate	innervate	VERB
fnp-3806	505	4	the	the	DET
fnp-3806	505	5	hippocampus	hippocampus	NOUN
fnp-3806	505	6	,	,	PUNCT
fnp-3806	505	7	amygdala	amygdala	NOUN
fnp-3806	505	8	,	,	PUNCT
fnp-3806	505	9	cerebral	cerebral	ADJ
fnp-3806	505	10	neocortex	neocortex	NOUN
fnp-3806	505	11	,	,	PUNCT
fnp-3806	505	12	and	and	CCONJ
fnp-3806	505	13	hypothalamus	hypothalamus	PROPN
fnp-3806	505	14	(	(	PUNCT
fnp-3806	505	15	575	575	NUM
fnp-3806	505	16	-	-	SYM
fnp-3806	505	17	577	577	NUM
fnp-3806	505	18	)	)	PUNCT
fnp-3806	505	19	.	.	PUNCT
fnp-3806	506	1	post	post	ADJ
fnp-3806	506	2	-	-	ADJ
fnp-3806	506	3	synaptic	synaptic	ADJ
fnp-3806	506	4	α1	α1	NOUN
fnp-3806	506	5	receptors	receptor	NOUN
fnp-3806	506	6	are	be	AUX
fnp-3806	506	7	excitatory	excitatory	ADJ
fnp-3806	506	8	,	,	PUNCT
fnp-3806	506	9	whereas	whereas	SCONJ
fnp-3806	506	10	perisomatic	perisomatic	ADJ
fnp-3806	506	11	and	and	CCONJ
fnp-3806	506	12	pre	pre	ADJ
fnp-3806	506	13	-	-	ADJ
fnp-3806	506	14	synaptic	synaptic	ADJ
fnp-3806	506	15	α2	α2	ADJ
fnp-3806	506	16	receptors	receptor	NOUN
fnp-3806	506	17	are	be	AUX
fnp-3806	506	18	inhibitory	inhibitory	ADJ
fnp-3806	506	19	(	(	PUNCT
fnp-3806	506	20	578	578	NUM
fnp-3806	506	21	)	)	PUNCT
fnp-3806	506	22	.	.	PUNCT
fnp-3806	507	1	adrenergic	adrenergic	ADJ
fnp-3806	507	2	receptors	receptor	NOUN
fnp-3806	507	3	are	be	AUX
fnp-3806	507	4	widely	widely	ADV
fnp-3806	507	5	distributed	distribute	VERB
fnp-3806	507	6	in	in	ADP
fnp-3806	507	7	the	the	DET
fnp-3806	507	8	brain	brain	NOUN
fnp-3806	507	9	(	(	PUNCT
fnp-3806	507	10	579	579	NUM
fnp-3806	507	11	,	,	PUNCT
fnp-3806	507	12	580	580	NUM
fnp-3806	507	13	)	)	PUNCT
fnp-3806	507	14	.	.	PUNCT
fnp-3806	508	1	neurons	neuron	NOUN
fnp-3806	508	2	of	of	ADP
fnp-3806	508	3	the	the	DET
fnp-3806	508	4	locus	locus	ADJ
fnp-3806	508	5	coeruleus	coeruleus	NOUN
fnp-3806	508	6	excite	excite	VERB
fnp-3806	508	7	the	the	DET
fnp-3806	508	8	cerebral	cerebral	ADJ
fnp-3806	508	9	cortex	cortex	NOUN
fnp-3806	508	10	principally	principally	ADV
fnp-3806	508	11	through	through	ADP
fnp-3806	508	12	α1	α1	PROPN
fnp-3806	508	13	receptor	receptor	NOUN
fnp-3806	508	14	signaling	signal	VERB
fnp-3806	508	15	(	(	PUNCT
fnp-3806	508	16	581	581	NUM
fnp-3806	508	17	,	,	PUNCT
fnp-3806	508	18	582	582	NUM
fnp-3806	508	19	)	)	PUNCT
fnp-3806	508	20	.	.	PUNCT
fnp-3806	509	1	the	the	DET
fnp-3806	509	2	locus	locus	ADJ
fnp-3806	509	3	coeruleus	coeruleus	NOUN
fnp-3806	509	4	-	-	PUNCT
fnp-3806	509	5	noradrenergic	noradrenergic	ADJ
fnp-3806	509	6	system	system	NOUN
fnp-3806	509	7	has	have	VERB
fnp-3806	509	8	a	a	DET
fnp-3806	509	9	major	major	ADJ
fnp-3806	509	10	role	role	NOUN
fnp-3806	509	11	in	in	ADP
fnp-3806	509	12	arousal	arousal	NOUN
fnp-3806	509	13	,	,	PUNCT
fnp-3806	509	14	attention	attention	NOUN
fnp-3806	509	15	,	,	PUNCT
fnp-3806	509	16	and	and	CCONJ
fnp-3806	509	17	stress	stress	NOUN
fnp-3806	509	18	responses	response	NOUN
fnp-3806	509	19	.	.	PUNCT
fnp-3806	510	1	in	in	ADP
fnp-3806	510	2	the	the	DET
fnp-3806	510	3	brain	brain	NOUN
fnp-3806	510	4	,	,	PUNCT
fnp-3806	510	5	norepinephrine	norepinephrine	NOUN
fnp-3806	510	6	may	may	AUX
fnp-3806	510	7	also	also	ADV
fnp-3806	510	8	contribute	contribute	VERB
fnp-3806	510	9	to	to	ADP
fnp-3806	510	10	long	long	ADJ
fnp-3806	510	11	-	-	PUNCT
fnp-3806	510	12	term	term	NOUN
fnp-3806	510	13	synaptic	synaptic	ADJ
fnp-3806	510	14	plasticity	plasticity	NOUN
fnp-3806	510	15	,	,	PUNCT
fnp-3806	510	16	pain	pain	NOUN
fnp-3806	510	17	modulation	modulation	NOUN
fnp-3806	510	18	,	,	PUNCT
fnp-3806	510	19	motor	motor	NOUN
fnp-3806	510	20	control	control	NOUN
fnp-3806	510	21	,	,	PUNCT
fnp-3806	510	22	and	and	CCONJ
fnp-3806	510	23	energy	energy	NOUN
fnp-3806	510	24	homeostasis	homeostasis	NOUN
fnp-3806	510	25	(	(	PUNCT
fnp-3806	510	26	583	583	NUM
fnp-3806	510	27	)	)	PUNCT
fnp-3806	510	28	.	.	PUNCT
fnp-3806	511	1	noradrenergic	noradrenergic	ADJ
fnp-3806	511	2	terminals	terminal	NOUN
fnp-3806	511	3	are	be	AUX
fnp-3806	511	4	also	also	ADV
fnp-3806	511	5	in	in	ADP
fnp-3806	511	6	contact	contact	NOUN
fnp-3806	511	7	with	with	ADP
fnp-3806	511	8	glial	glial	ADJ
fnp-3806	511	9	cells	cell	NOUN
fnp-3806	511	10	and	and	CCONJ
fnp-3806	511	11	blood	blood	NOUN
fnp-3806	511	12	vessels	vessel	NOUN
fnp-3806	511	13	(	(	PUNCT
fnp-3806	511	14	584	584	NUM
fnp-3806	511	15	-	-	SYM
fnp-3806	511	16	586	586	NUM
fnp-3806	511	17	)	)	PUNCT
fnp-3806	511	18	.	.	PUNCT
fnp-3806	512	1	due	due	ADP
fnp-3806	512	2	to	to	ADP
fnp-3806	512	3	these	these	DET
fnp-3806	512	4	connections	connection	NOUN
fnp-3806	512	5	,	,	PUNCT
fnp-3806	512	6	noradrenergic	noradrenergic	ADJ
fnp-3806	512	7	innervations	innervation	NOUN
fnp-3806	512	8	also	also	ADV
fnp-3806	512	9	modulate	modulate	VERB
fnp-3806	512	10	inflammation	inflammation	NOUN
fnp-3806	512	11	and	and	CCONJ
fnp-3806	512	12	cerebral	cerebral	ADJ
fnp-3806	512	13	blood	blood	NOUN
fnp-3806	512	14	flow	flow	NOUN
fnp-3806	512	15	(	(	PUNCT
fnp-3806	512	16	583	583	NUM
fnp-3806	512	17	,	,	PUNCT
fnp-3806	512	18	587	587	NUM
fnp-3806	512	19	-	-	SYM
fnp-3806	512	20	589	589	NUM
fnp-3806	512	21	)	)	PUNCT
fnp-3806	512	22	.	.	PUNCT
fnp-3806	513	1	in	in	ADP
fnp-3806	513	2	addition	addition	NOUN
fnp-3806	513	3	,	,	PUNCT
fnp-3806	513	4	the	the	DET
fnp-3806	513	5	noradrenergic	noradrenergic	ADJ
fnp-3806	513	6	system	system	NOUN
fnp-3806	513	7	interacts	interact	VERB
fnp-3806	513	8	with	with	ADP
fnp-3806	513	9	the	the	DET
fnp-3806	513	10	cholinergic	cholinergic	ADJ
fnp-3806	513	11	and	and	CCONJ
fnp-3806	513	12	gabaergic	gabaergic	ADJ
fnp-3806	513	13	systems	system	NOUN
fnp-3806	513	14	(	(	PUNCT
fnp-3806	513	15	576	576	NUM
fnp-3806	513	16	,	,	PUNCT
fnp-3806	513	17	590	590	NUM
fnp-3806	513	18	-	-	SYM
fnp-3806	513	19	592	592	NUM
fnp-3806	513	20	)	)	PUNCT
fnp-3806	513	21	.	.	PUNCT
fnp-3806	514	1	moreover	moreover	ADV
fnp-3806	514	2	,	,	PUNCT
fnp-3806	514	3	the	the	DET
fnp-3806	514	4	locus	locus	ADJ
fnp-3806	514	5	coeruleus	coeruleus	NOUN
fnp-3806	514	6	and	and	CCONJ
fnp-3806	514	7	the	the	DET
fnp-3806	514	8	raphe	raphe	NOUN
fnp-3806	514	9	nuclei	nucleus	NOUN
fnp-3806	514	10	are	be	AUX
fnp-3806	514	11	interconnected	interconnect	VERB
fnp-3806	514	12	(	(	PUNCT
fnp-3806	514	13	593	593	NUM
fnp-3806	514	14	,	,	PUNCT
fnp-3806	514	15	594	594	NUM
fnp-3806	514	16	)	)	PUNCT
fnp-3806	514	17	.	.	PUNCT
fnp-3806	515	1	finally	finally	ADV
fnp-3806	515	2	,	,	PUNCT
fnp-3806	515	3	orexin	orexin	NOUN
fnp-3806	515	4	/	/	SYM
fnp-3806	515	5	hypocretin	hypocretin	NOUN
fnp-3806	515	6	,	,	PUNCT
fnp-3806	515	7	histamine	histamine	NOUN
fnp-3806	515	8	and	and	CCONJ
fnp-3806	515	9	noradrenaline	noradrenaline	ADJ
fnp-3806	515	10	converge	converge	NOUN
fnp-3806	515	11	in	in	ADP
fnp-3806	515	12	the	the	DET
fnp-3806	515	13	dorsal	dorsal	NOUN
fnp-3806	515	14	raphe	raphe	NOUN
fnp-3806	515	15	nucleus	nucleus	NOUN
fnp-3806	515	16	(	(	PUNCT
fnp-3806	515	17	593	593	NUM
fnp-3806	515	18	)	)	PUNCT
fnp-3806	515	19	.	.	PUNCT
fnp-3806	516	1	the	the	DET
fnp-3806	516	2	locus	locus	NOUN
fnp-3806	516	3	coeruleus	coeruleus	NOUN
fnp-3806	516	4	is	be	AUX
fnp-3806	516	5	damaged	damage	VERB
fnp-3806	516	6	at	at	ADP
fnp-3806	516	7	early	early	ADJ
fnp-3806	516	8	stages	stage	NOUN
fnp-3806	516	9	of	of	ADP
fnp-3806	516	10	ad	ad	NOUN
fnp-3806	516	11	-	-	PUNCT
fnp-3806	516	12	related	relate	VERB
fnp-3806	516	13	pathology	pathology	NOUN
fnp-3806	516	14	(	(	PUNCT
fnp-3806	516	15	443	443	NUM
fnp-3806	516	16	,	,	PUNCT
fnp-3806	516	17	595	595	NUM
fnp-3806	516	18	-	-	SYM
fnp-3806	516	19	598	598	NUM
fnp-3806	516	20	)	)	PUNCT
fnp-3806	516	21	(	(	PUNCT
fnp-3806	516	22	see	see	VERB
fnp-3806	516	23	also	also	ADV
fnp-3806	516	24	section	section	NOUN
fnp-3806	516	25	4	4	NUM
fnp-3806	516	26	)	)	PUNCT
fnp-3806	516	27	.	.	PUNCT
fnp-3806	517	1	at	at	ADP
fnp-3806	517	2	these	these	DET
fnp-3806	517	3	first	first	ADJ
fnp-3806	517	4	stages	stage	NOUN
fnp-3806	517	5	,	,	PUNCT
fnp-3806	517	6	nfts	nft	NOUN
fnp-3806	517	7	accompany	accompany	NOUN
fnp-3806	517	8	neuron	neuron	PROPN
fnp-3806	517	9	loss	loss	NOUN
fnp-3806	517	10	,	,	PUNCT
fnp-3806	517	11	but	but	CCONJ
fnp-3806	517	12	sps	sps	PROPN
fnp-3806	517	13	only	only	ADV
fnp-3806	517	14	appear	appear	VERB
fnp-3806	517	15	in	in	ADP
fnp-3806	517	16	some	some	DET
fnp-3806	517	17	cases	case	NOUN
fnp-3806	517	18	at	at	ADP
fnp-3806	517	19	advanced	advanced	ADJ
fnp-3806	517	20	thal	thal	ADJ
fnp-3806	517	21	phases	phase	NOUN
fnp-3806	517	22	of	of	ADP
fnp-3806	517	23	β	β	NOUN
fnp-3806	517	24	-	-	ADJ
fnp-3806	517	25	amyloid	amyloid	ADJ
fnp-3806	517	26	deposition	deposition	NOUN
fnp-3806	517	27	.	.	PUNCT
fnp-3806	518	1	in	in	ADP
fnp-3806	518	2	contrast	contrast	NOUN
fnp-3806	518	3	to	to	ADP
fnp-3806	518	4	the	the	DET
fnp-3806	518	5	massive	massive	ADJ
fnp-3806	518	6	loss	loss	NOUN
fnp-3806	518	7	of	of	ADP
fnp-3806	518	8	noradrenergic	noradrenergic	ADJ
fnp-3806	518	9	neurons	neuron	NOUN
fnp-3806	518	10	,	,	PUNCT
fnp-3806	518	11	calbindin	calbindin	VERB
fnp-3806	518	12	-	-	PUNCT
fnp-3806	518	13	immunoreactive	immunoreactive	ADJ
fnp-3806	518	14	neurons	neuron	NOUN
fnp-3806	518	15	are	be	AUX
fnp-3806	518	16	preserved	preserve	VERB
fnp-3806	518	17	in	in	ADP
fnp-3806	518	18	the	the	DET
fnp-3806	518	19	locus	locus	ADJ
fnp-3806	518	20	coeruleus	coeruleus	NOUN
fnp-3806	518	21	even	even	ADV
fnp-3806	518	22	at	at	ADP
fnp-3806	518	23	advanced	advanced	ADJ
fnp-3806	518	24	stages	stage	NOUN
fnp-3806	518	25	of	of	ADP
fnp-3806	518	26	nft	nft	PROPN
fnp-3806	518	27	pathology	pathology	PROPN
fnp-3806	518	28	(	(	PUNCT
fnp-3806	518	29	599	599	NUM
fnp-3806	518	30	)	)	PUNCT
fnp-3806	518	31	.	.	PUNCT
fnp-3806	519	1	early	early	ADJ
fnp-3806	519	2	neuronal	neuronal	ADJ
fnp-3806	519	3	alterations	alteration	NOUN
fnp-3806	519	4	in	in	ADP
fnp-3806	519	5	the	the	DET
fnp-3806	519	6	locus	locus	NOUN
fnp-3806	519	7	coeruleus	coeruleus	NOUN
fnp-3806	519	8	are	be	AUX
fnp-3806	519	9	accompanied	accompany	VERB
fnp-3806	519	10	by	by	ADP
fnp-3806	519	11	abnormalities	abnormality	NOUN
fnp-3806	519	12	in	in	ADP
fnp-3806	519	13	the	the	DET
fnp-3806	519	14	ascending	ascend	VERB
fnp-3806	519	15	noradrenergic	noradrenergic	ADJ
fnp-3806	519	16	system	system	NOUN
fnp-3806	519	17	(	(	PUNCT
fnp-3806	519	18	600	600	NUM
fnp-3806	519	19	-	-	SYM
fnp-3806	519	20	602	602	NUM
fnp-3806	519	21	)	)	PUNCT
fnp-3806	519	22	.	.	PUNCT
fnp-3806	520	1	increased	increase	VERB
fnp-3806	520	2	α2a	α2a	NOUN
fnp-3806	520	3	adrenergic	adrenergic	ADJ
fnp-3806	520	4	receptor	receptor	NOUN
fnp-3806	520	5	protein	protein	NOUN
fnp-3806	520	6	occurs	occur	VERB
fnp-3806	520	7	in	in	ADP
fnp-3806	520	8	the	the	DET
fnp-3806	520	9	amygdala	amygdala	NOUN
fnp-3806	520	10	and	and	CCONJ
fnp-3806	520	11	hippocampus	hippocampus	NOUN
fnp-3806	520	12	in	in	ADP
fnp-3806	520	13	parallel	parallel	NOUN
fnp-3806	520	14	with	with	ADP
fnp-3806	520	15	early	early	ADJ
fnp-3806	520	16	nft	nft	PROPN
fnp-3806	520	17	pathology	pathology	NOUN
fnp-3806	520	18	in	in	ADP
fnp-3806	520	19	the	the	DET
fnp-3806	520	20	locus	locus	ADJ
fnp-3806	520	21	coeruleus	coeruleus	NOUN
fnp-3806	520	22	(	(	PUNCT
fnp-3806	520	23	338	338	NUM
fnp-3806	520	24	)	)	PUNCT
fnp-3806	520	25	.	.	PUNCT
fnp-3806	521	1	in	in	ADP
fnp-3806	521	2	contrast	contrast	NOUN
fnp-3806	521	3	,	,	PUNCT
fnp-3806	521	4	reduced	reduce	VERB
fnp-3806	521	5	dbh	dbh	NOUN
fnp-3806	521	6	activity	activity	NOUN
fnp-3806	521	7	is	be	AUX
fnp-3806	521	8	found	find	VERB
fnp-3806	521	9	in	in	ADP
fnp-3806	521	10	the	the	DET
fnp-3806	521	11	post	post	ADJ
fnp-3806	521	12	-	-	ADJ
fnp-3806	521	13	mortem	mortem	ADJ
fnp-3806	521	14	hippocampus	hippocampus	NOUN
fnp-3806	521	15	and	and	CCONJ
fnp-3806	521	16	neocortex	neocortex	NOUN
fnp-3806	521	17	,	,	PUNCT
fnp-3806	521	18	probably	probably	ADV
fnp-3806	521	19	as	as	ADP
fnp-3806	521	20	a	a	DET
fnp-3806	521	21	compensatory	compensatory	ADJ
fnp-3806	521	22	mechanism	mechanism	NOUN
fnp-3806	521	23	to	to	ADP
fnp-3806	521	24	noradrenaline	noradrenaline	ADJ
fnp-3806	521	25	lessening	lessening	NOUN
fnp-3806	521	26	(	(	PUNCT
fnp-3806	521	27	603	603	NUM
fnp-3806	521	28	,	,	PUNCT
fnp-3806	521	29	604	604	NUM
fnp-3806	521	30	)	)	PUNCT
fnp-3806	521	31	.	.	PUNCT
fnp-3806	522	1	dbh	dbh	PROPN
fnp-3806	522	2	levels	level	NOUN
fnp-3806	522	3	are	be	AUX
fnp-3806	522	4	also	also	ADV
fnp-3806	522	5	reduced	reduce	VERB
fnp-3806	522	6	in	in	ADP
fnp-3806	522	7	plasma	plasma	NOUN
fnp-3806	522	8	at	at	ADP
fnp-3806	522	9	early	early	ADJ
fnp-3806	522	10	stages	stage	NOUN
fnp-3806	522	11	of	of	ADP
fnp-3806	522	12	ad	ad	NOUN
fnp-3806	522	13	(	(	PUNCT
fnp-3806	522	14	605	605	NUM
fnp-3806	522	15	)	)	PUNCT
fnp-3806	522	16	.	.	PUNCT
fnp-3806	523	1	moreover	moreover	ADV
fnp-3806	523	2	,	,	PUNCT
fnp-3806	523	3	connectivity	connectivity	NOUN
fnp-3806	523	4	between	between	ADP
fnp-3806	523	5	norepinephrine	norepinephrine	NOUN
fnp-3806	523	6	and	and	CCONJ
fnp-3806	523	7	dopamine	dopamine	NOUN
fnp-3806	523	8	brainstem	brainstem	NOUN
fnp-3806	523	9	centers	center	NOUN
fnp-3806	523	10	is	be	AUX
fnp-3806	523	11	disrupted	disrupt	VERB
fnp-3806	523	12	in	in	ADP
fnp-3806	523	13	sad	sad	ADJ
fnp-3806	523	14	(	(	PUNCT
fnp-3806	523	15	606	606	NUM
fnp-3806	523	16	)	)	PUNCT
fnp-3806	523	17	.	.	PUNCT
fnp-3806	524	1	the	the	DET
fnp-3806	524	2	orexin	orexin	NOUN
fnp-3806	524	3	system	system	NOUN
fnp-3806	524	4	is	be	AUX
fnp-3806	524	5	compromised	compromise	VERB
fnp-3806	524	6	in	in	ADP
fnp-3806	524	7	sad	sad	ADJ
fnp-3806	524	8	,	,	PUNCT
fnp-3806	524	9	thus	thus	ADV
fnp-3806	524	10	contributing	contribute	VERB
fnp-3806	524	11	,	,	PUNCT
fnp-3806	524	12	in	in	ADP
fnp-3806	524	13	combination	combination	NOUN
fnp-3806	524	14	with	with	ADP
fnp-3806	524	15	the	the	DET
fnp-3806	524	16	noradrenergic	noradrenergic	ADJ
fnp-3806	524	17	and	and	CCONJ
fnp-3806	524	18	serotonin	serotonin	NOUN
fnp-3806	524	19	decay	decay	NOUN
fnp-3806	524	20	,	,	PUNCT
fnp-3806	524	21	to	to	PART
fnp-3806	524	22	altered	alter	VERB
fnp-3806	524	23	sleep	sleep	NOUN
fnp-3806	524	24	in	in	ADP
fnp-3806	524	25	sad	sad	ADJ
fnp-3806	524	26	(	(	PUNCT
fnp-3806	524	27	607	607	NUM
fnp-3806	524	28	-	-	SYM
fnp-3806	524	29	611	611	NUM
fnp-3806	524	30	)	)	PUNCT
fnp-3806	524	31	.	.	PUNCT
fnp-3806	525	1	7f	7f	X
fnp-3806	525	2	.	.	PUNCT
fnp-3806	526	1	adenosine	adenosine	NOUN
fnp-3806	526	2	receptors	receptor	NOUN
fnp-3806	526	3	adenosine	adenosine	NOUN
fnp-3806	526	4	is	be	AUX
fnp-3806	526	5	transported	transport	VERB
fnp-3806	526	6	across	across	ADP
fnp-3806	526	7	the	the	DET
fnp-3806	526	8	plasma	plasma	NOUN
fnp-3806	526	9	membrane	membrane	NOUN
fnp-3806	526	10	based	base	VERB
fnp-3806	526	11	on	on	ADP
fnp-3806	526	12	:	:	PUNCT
fnp-3806	526	13	a	a	X
fnp-3806	526	14	)	)	PUNCT
fnp-3806	526	15	its	its	PRON
fnp-3806	526	16	concentration	concentration	NOUN
fnp-3806	526	17	gradients	gradient	NOUN
fnp-3806	526	18	,	,	PUNCT
fnp-3806	526	19	and	and	CCONJ
fnp-3806	526	20	b	b	X
fnp-3806	526	21	)	)	PUNCT
fnp-3806	526	22	active	active	ADJ
fnp-3806	526	23	na+-dependent	na+-dependent	PROPN
fnp-3806	526	24	transporters	transporter	NOUN
fnp-3806	526	25	that	that	PRON
fnp-3806	526	26	carry	carry	VERB
fnp-3806	526	27	adenosine	adenosine	NOUN
fnp-3806	526	28	against	against	ADP
fnp-3806	526	29	its	its	PRON
fnp-3806	526	30	concentration	concentration	NOUN
fnp-3806	526	31	gradient	gradient	NOUN
fnp-3806	526	32	.	.	PUNCT
fnp-3806	527	1	adenosine	adenosine	NOUN
fnp-3806	527	2	receptors	receptor	NOUN
fnp-3806	527	3	are	be	AUX
fnp-3806	527	4	purinergic	purinergic	NOUN
fnp-3806	527	5	gpcr	gpcr	NOUN
fnp-3806	527	6	classified	classify	VERB
fnp-3806	527	7	into	into	ADP
fnp-3806	527	8	a1	a1	PROPN
fnp-3806	527	9	,	,	PUNCT
fnp-3806	527	10	a2a	a2a	PROPN
fnp-3806	527	11	,	,	PUNCT
fnp-3806	527	12	a2b	a2b	PROPN
fnp-3806	527	13	,	,	PUNCT
fnp-3806	527	14	and	and	CCONJ
fnp-3806	527	15	a3	a3	NOUN
fnp-3806	527	16	receptors	receptor	NOUN
fnp-3806	527	17	.	.	PUNCT
fnp-3806	528	1	a1	a1	NOUN
fnp-3806	528	2	and	and	CCONJ
fnp-3806	528	3	a3	a3	NOUN
fnp-3806	528	4	receptors	receptor	NOUN
fnp-3806	528	5	inhibit	inhibit	VERB
fnp-3806	528	6	ac	ac	ADV
fnp-3806	528	7	through	through	ADP
fnp-3806	528	8	gi	gi	PROPN
fnp-3806	528	9	/	/	SYM
fnp-3806	528	10	o	o	NOUN
fnp-3806	528	11	proteins	protein	NOUN
fnp-3806	528	12	,	,	PUNCT
fnp-3806	528	13	while	while	SCONJ
fnp-3806	528	14	a2a	a2a	PROPN
fnp-3806	528	15	and	and	CCONJ
fnp-3806	528	16	a2b	a2b	PROPN
fnp-3806	528	17	receptors	receptor	NOUN
fnp-3806	528	18	stimulate	stimulate	VERB
fnp-3806	528	19	ac	ac	ADV
fnp-3806	528	20	through	through	ADP
fnp-3806	528	21	gs	gs	NOUN
fnp-3806	528	22	proteins	protein	NOUN
fnp-3806	528	23	(	(	PUNCT
fnp-3806	528	24	612	612	NUM
fnp-3806	528	25	,	,	PUNCT
fnp-3806	528	26	613	613	NUM
fnp-3806	528	27	)	)	PUNCT
fnp-3806	528	28	.	.	PUNCT
fnp-3806	529	1	adenosine	adenosine	NOUN
fnp-3806	529	2	receptors	receptor	NOUN
fnp-3806	529	3	are	be	AUX
fnp-3806	529	4	present	present	ADJ
fnp-3806	529	5	in	in	ADP
fnp-3806	529	6	subpopulations	subpopulation	NOUN
fnp-3806	529	7	of	of	ADP
fnp-3806	529	8	neurons	neuron	NOUN
fnp-3806	529	9	,	,	PUNCT
fnp-3806	529	10	astrocytes	astrocyte	NOUN
fnp-3806	529	11	,	,	PUNCT
fnp-3806	529	12	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	529	13	,	,	PUNCT
fnp-3806	529	14	and	and	CCONJ
fnp-3806	529	15	microglia	microglia	ADJ
fnp-3806	529	16	(	(	PUNCT
fnp-3806	529	17	614	614	NUM
fnp-3806	529	18	-	-	SYM
fnp-3806	529	19	616	616	NUM
fnp-3806	529	20	)	)	PUNCT
fnp-3806	529	21	.	.	PUNCT
fnp-3806	530	1	adenosine	adenosine	NOUN
fnp-3806	530	2	receptors	receptor	NOUN
fnp-3806	530	3	modulate	modulate	VERB
fnp-3806	530	4	the	the	DET
fnp-3806	530	5	release	release	NOUN
fnp-3806	530	6	of	of	ADP
fnp-3806	530	7	glutamate	glutamate	NOUN
fnp-3806	530	8	,	,	PUNCT
fnp-3806	530	9	gaba	gaba	NOUN
fnp-3806	530	10	,	,	PUNCT
fnp-3806	530	11	acetylcholine	acetylcholine	NOUN
fnp-3806	530	12	,	,	PUNCT
fnp-3806	530	13	noradrenaline	noradrenaline	NOUN
fnp-3806	530	14	,	,	PUNCT
fnp-3806	530	15	and	and	CCONJ
fnp-3806	530	16	serotonin	serotonin	VERB
fnp-3806	530	17	(	(	PUNCT
fnp-3806	530	18	616	616	NUM
fnp-3806	530	19	-	-	SYM
fnp-3806	530	20	623	623	NUM
fnp-3806	530	21	)	)	PUNCT
fnp-3806	530	22	.	.	PUNCT
fnp-3806	531	1	early	early	ADJ
fnp-3806	531	2	autoradiographic	autoradiographic	ADJ
fnp-3806	531	3	studies	study	NOUN
fnp-3806	531	4	showed	show	VERB
fnp-3806	531	5	decreased	decrease	VERB
fnp-3806	531	6	a1	a1	NOUN
fnp-3806	531	7	expression	expression	NOUN
fnp-3806	531	8	in	in	ADP
fnp-3806	531	9	the	the	DET
fnp-3806	531	10	hippocampus	hippocampus	NOUN
fnp-3806	531	11	at	at	ADP
fnp-3806	531	12	advanced	advanced	ADJ
fnp-3806	531	13	stages	stage	NOUN
fnp-3806	531	14	of	of	ADP
fnp-3806	531	15	sad	sad	ADJ
fnp-3806	531	16	(	(	PUNCT
fnp-3806	531	17	624	624	NUM
fnp-3806	531	18	-	-	NUM
fnp-3806	531	19	627	627	NUM
fnp-3806	531	20	)	)	PUNCT
fnp-3806	531	21	.	.	PUNCT
fnp-3806	532	1	however	however	ADV
fnp-3806	532	2	,	,	PUNCT
fnp-3806	532	3	a1	a1	NOUN
fnp-3806	532	4	receptors	receptor	NOUN
fnp-3806	532	5	accumulate	accumulate	VERB
fnp-3806	532	6	in	in	ADP
fnp-3806	532	7	neurons	neuron	NOUN
fnp-3806	532	8	with	with	ADP
fnp-3806	532	9	nfts	nft	NOUN
fnp-3806	532	10	in	in	ADP
fnp-3806	532	11	sad	sad	ADJ
fnp-3806	532	12	(	(	PUNCT
fnp-3806	532	13	628	628	NUM
fnp-3806	532	14	)	)	PUNCT
fnp-3806	532	15	.	.	PUNCT
fnp-3806	533	1	more	more	ADV
fnp-3806	533	2	recent	recent	ADJ
fnp-3806	533	3	studies	study	NOUN
fnp-3806	533	4	at	at	ADP
fnp-3806	533	5	first	first	ADJ
fnp-3806	533	6	stages	stage	NOUN
fnp-3806	533	7	of	of	ADP
fnp-3806	533	8	nft	nft	PROPN
fnp-3806	533	9	pathology	pathology	PROPN
fnp-3806	533	10	have	have	AUX
fnp-3806	533	11	shown	show	VERB
fnp-3806	533	12	upregulation	upregulation	NOUN
fnp-3806	533	13	of	of	ADP
fnp-3806	533	14	adenosine	adenosine	ADJ
fnp-3806	533	15	receptors	receptor	NOUN
fnp-3806	533	16	and	and	CCONJ
fnp-3806	533	17	sensitization	sensitization	NOUN
fnp-3806	533	18	of	of	ADP
fnp-3806	533	19	their	their	PRON
fnp-3806	533	20	specific	specific	ADJ
fnp-3806	533	21	signaling	signal	VERB
fnp-3806	533	22	pathways	pathway	NOUN
fnp-3806	533	23	preceding	precede	VERB
fnp-3806	533	24	nfts	nft	NOUN
fnp-3806	533	25	and	and	CCONJ
fnp-3806	533	26	sps	sps	NOUN
fnp-3806	533	27	in	in	ADP
fnp-3806	533	28	the	the	DET
fnp-3806	533	29	frontal	frontal	ADJ
fnp-3806	533	30	cortex	cortex	NOUN
fnp-3806	533	31	(	(	PUNCT
fnp-3806	533	32	629	629	NUM
fnp-3806	533	33	)	)	PUNCT
fnp-3806	533	34	.	.	PUNCT
fnp-3806	534	1	7	7	NUM
fnp-3806	534	2	g.	g.	NOUN
fnp-3806	534	3	endocannabinoids	endocannabinoid	NOUN
fnp-3806	534	4	and	and	CCONJ
fnp-3806	534	5	cannabinoid	cannabinoid	NOUN
fnp-3806	534	6	receptors	receptor	NOUN
fnp-3806	534	7	(	(	PUNCT
fnp-3806	534	8	cbrs	cbrs	NOUN
fnp-3806	534	9	)	)	PUNCT
fnp-3806	534	10	cbrs	cbrs	PROPN
fnp-3806	534	11	are	be	AUX
fnp-3806	534	12	classified	classify	VERB
fnp-3806	534	13	as	as	ADP
fnp-3806	534	14	type	type	NOUN
fnp-3806	534	15	1	1	NUM
fnp-3806	534	16	(	(	PUNCT
fnp-3806	534	17	cb1r	cb1r	X
fnp-3806	534	18	)	)	PUNCT
fnp-3806	534	19	and	and	CCONJ
fnp-3806	534	20	type	type	NOUN
fnp-3806	534	21	2	2	NUM
fnp-3806	534	22	(	(	PUNCT
fnp-3806	534	23	cb2r	cb2r	PROPN
fnp-3806	534	24	)	)	PUNCT
fnp-3806	534	25	(	(	PUNCT
fnp-3806	534	26	630	630	NUM
fnp-3806	534	27	)	)	PUNCT
fnp-3806	534	28	.	.	PUNCT
fnp-3806	535	1	anandamide	anandamide	NOUN
fnp-3806	535	2	(	(	PUNCT
fnp-3806	535	3	n	n	CCONJ
fnp-3806	535	4	-	-	PUNCT
fnp-3806	535	5	arachidonoyl	arachidonoyl	ADJ
fnp-3806	535	6	ethanolamine	ethanolamine	NOUN
fnp-3806	535	7	,	,	PUNCT
fnp-3806	535	8	aea	aea	PROPN
fnp-3806	535	9	)	)	PUNCT
fnp-3806	535	10	and	and	CCONJ
fnp-3806	535	11	2	2	NUM
fnp-3806	535	12	-	-	PUNCT
fnp-3806	535	13	arachidonoyl	arachidonoyl	ADJ
fnp-3806	535	14	glycerol	glycerol	NOUN
fnp-3806	535	15	(	(	PUNCT
fnp-3806	535	16	2	2	NUM
fnp-3806	535	17	-	-	PUNCT
fnp-3806	535	18	ag	ag	NOUN
fnp-3806	535	19	)	)	PUNCT
fnp-3806	535	20	are	be	AUX
fnp-3806	535	21	the	the	DET
fnp-3806	535	22	main	main	ADJ
fnp-3806	535	23	endogenous	endogenous	ADJ
fnp-3806	535	24	ligands	ligand	NOUN
fnp-3806	535	25	of	of	ADP
fnp-3806	535	26	cbrs	cbrs	NOUN
fnp-3806	535	27	(	(	PUNCT
fnp-3806	535	28	631	631	NUM
fnp-3806	535	29	-	-	SYM
fnp-3806	535	30	634	634	NUM
fnp-3806	535	31	)	)	PUNCT
fnp-3806	535	32	.	.	PUNCT
fnp-3806	536	1	both	both	DET
fnp-3806	536	2	endocannabinoids	endocannabinoid	NOUN
fnp-3806	536	3	derive	derive	VERB
fnp-3806	536	4	from	from	ADP
fnp-3806	536	5	arachidonic	arachidonic	ADJ
fnp-3806	536	6	acid	acid	NOUN
fnp-3806	536	7	(	(	PUNCT
fnp-3806	536	8	aa	aa	NOUN
fnp-3806	536	9	)	)	PUNCT
fnp-3806	536	10	.	.	PUNCT
fnp-3806	537	1	they	they	PRON
fnp-3806	537	2	are	be	AUX
fnp-3806	537	3	synthesized	synthesize	VERB
fnp-3806	537	4	and	and	CCONJ
fnp-3806	537	5	metabolized	metabolize	VERB
fnp-3806	537	6	by	by	ADP
fnp-3806	537	7	different	different	ADJ
fnp-3806	537	8	pathways	pathway	NOUN
fnp-3806	537	9	and	and	CCONJ
fnp-3806	537	10	induce	induce	VERB
fnp-3806	537	11	specific	specific	ADJ
fnp-3806	537	12	biological	biological	ADJ
fnp-3806	537	13	functions	function	NOUN
fnp-3806	537	14	.	.	PUNCT
fnp-3806	538	1	in	in	ADP
fnp-3806	538	2	the	the	DET
fnp-3806	538	3	human	human	ADJ
fnp-3806	538	4	brain	brain	NOUN
fnp-3806	538	5	,	,	PUNCT
fnp-3806	538	6	cb1rs	cb1rs	PROPN
fnp-3806	538	7	are	be	AUX
fnp-3806	538	8	mainly	mainly	ADV
fnp-3806	538	9	expressed	express	VERB
fnp-3806	538	10	in	in	ADP
fnp-3806	538	11	the	the	DET
fnp-3806	538	12	limbic	limbic	ADJ
fnp-3806	538	13	system	system	NOUN
fnp-3806	538	14	.	.	PUNCT
fnp-3806	539	1	cb1rs	cb1rs	NOUN
fnp-3806	539	2	localize	localize	NOUN
fnp-3806	539	3	in	in	ADP
fnp-3806	539	4	the	the	DET
fnp-3806	539	5	pre	pre	NOUN
fnp-3806	539	6	-	-	ADJ
fnp-3806	539	7	synapses	synapses	ADV
fnp-3806	539	8	modulating	modulate	VERB
fnp-3806	539	9	glutamate	glutamate	NOUN
fnp-3806	539	10	and	and	CCONJ
fnp-3806	539	11	gaba	gaba	NOUN
fnp-3806	539	12	neurotransmission	neurotransmission	NOUN
fnp-3806	539	13	(	(	PUNCT
fnp-3806	539	14	635	635	NUM
fnp-3806	539	15	-	-	SYM
fnp-3806	539	16	641	641	NUM
fnp-3806	539	17	)	)	PUNCT
fnp-3806	539	18	.	.	PUNCT
fnp-3806	540	1	cb2rs	cb2rs	PROPN
fnp-3806	540	2	are	be	AUX
fnp-3806	540	3	expressed	express	VERB
fnp-3806	540	4	in	in	ADP
fnp-3806	540	5	microglia	microglia	NOUN
fnp-3806	540	6	,	,	PUNCT
fnp-3806	540	7	and	and	CCONJ
fnp-3806	540	8	participate	participate	VERB
fnp-3806	540	9	in	in	ADP
fnp-3806	540	10	inflammation	inflammation	NOUN
fnp-3806	540	11	and	and	CCONJ
fnp-3806	540	12	phagocytosis	phagocytosis	NOUN
fnp-3806	540	13	(	(	PUNCT
fnp-3806	540	14	642	642	NUM
fnp-3806	540	15	,	,	PUNCT
fnp-3806	540	16	643	643	NUM
fnp-3806	540	17	)	)	PUNCT
fnp-3806	540	18	.	.	PUNCT
fnp-3806	541	1	low	low	ADJ
fnp-3806	541	2	levels	level	NOUN
fnp-3806	541	3	of	of	ADP
fnp-3806	541	4	cb2r	cb2r	PROPN
fnp-3806	541	5	expression	expression	NOUN
fnp-3806	541	6	have	have	AUX
fnp-3806	541	7	also	also	ADV
fnp-3806	541	8	been	be	AUX
fnp-3806	541	9	identified	identify	VERB
fnp-3806	541	10	in	in	ADP
fnp-3806	541	11	some	some	DET
fnp-3806	541	12	neurons	neuron	NOUN
fnp-3806	541	13	(	(	PUNCT
fnp-3806	541	14	644	644	NUM
fnp-3806	541	15	-	-	SYM
fnp-3806	541	16	646	646	NUM
fnp-3806	541	17	)	)	PUNCT
fnp-3806	541	18	.	.	PUNCT
fnp-3806	542	1	cannabinoid	cannabinoid	PROPN
fnp-3806	542	2	compounds	compound	NOUN
fnp-3806	542	3	may	may	AUX
fnp-3806	542	4	also	also	ADV
fnp-3806	542	5	bind	bind	VERB
fnp-3806	542	6	to	to	ADP
fnp-3806	542	7	other	other	ADJ
fnp-3806	542	8	receptors	receptor	NOUN
fnp-3806	542	9	,	,	PUNCT
fnp-3806	542	10	such	such	ADJ
fnp-3806	542	11	as	as	ADP
fnp-3806	542	12	gpr55	gpr55	PROPN
fnp-3806	542	13	,	,	PUNCT
fnp-3806	542	14	peroxisome	peroxisome	VERB
fnp-3806	542	15	proliferator	proliferator	NOUN
fnp-3806	542	16	-	-	PUNCT
fnp-3806	542	17	activated	activate	VERB
fnp-3806	542	18	receptors	receptor	NOUN
fnp-3806	542	19	pparα	pparα	NOUN
fnp-3806	542	20	and	and	CCONJ
fnp-3806	542	21	pparγ	pparγ	ADJ
fnp-3806	542	22	,	,	PUNCT
fnp-3806	542	23	and	and	CCONJ
fnp-3806	542	24	transient	transient	ADJ
fnp-3806	542	25	receptor	receptor	NOUN
fnp-3806	542	26	potential	potential	NOUN
fnp-3806	542	27	vannilloid-1	vannilloid-1	NUM
fnp-3806	542	28	channels	channel	NOUN
fnp-3806	542	29	(	(	PUNCT
fnp-3806	542	30	647	647	NUM
fnp-3806	542	31	,	,	PUNCT
fnp-3806	542	32	648	648	NUM
fnp-3806	542	33	)	)	PUNCT
fnp-3806	542	34	.	.	PUNCT
fnp-3806	543	1	the	the	DET
fnp-3806	543	2	study	study	NOUN
fnp-3806	543	3	of	of	ADP
fnp-3806	543	4	expression	expression	NOUN
fnp-3806	543	5	of	of	ADP
fnp-3806	543	6	cb1rs	cb1rs	NOUN
fnp-3806	543	7	and	and	CCONJ
fnp-3806	543	8	mediators	mediator	NOUN
fnp-3806	543	9	in	in	ADP
fnp-3806	543	10	sad	sad	ADJ
fnp-3806	543	11	has	have	AUX
fnp-3806	543	12	yielded	yield	VERB
fnp-3806	543	13	variable	variable	ADJ
fnp-3806	543	14	results	result	NOUN
fnp-3806	543	15	(	(	PUNCT
fnp-3806	543	16	649	649	NUM
fnp-3806	543	17	)	)	PUNCT
fnp-3806	543	18	.	.	PUNCT
fnp-3806	544	1	in	in	ADP
fnp-3806	544	2	contrast	contrast	NOUN
fnp-3806	544	3	,	,	PUNCT
fnp-3806	544	4	increased	increase	VERB
fnp-3806	544	5	cb2r	cb2r	NOUN
fnp-3806	544	6	expression	expression	NOUN
fnp-3806	544	7	in	in	ADP
fnp-3806	544	8	microglia	microglia	ADJ
fnp-3806	544	9	surrounding	surround	VERB
fnp-3806	544	10	sps	sps	NOUN
fnp-3806	544	11	is	be	AUX
fnp-3806	544	12	consistently	consistently	ADV
fnp-3806	544	13	documented	document	VERB
fnp-3806	544	14	(	(	PUNCT
fnp-3806	544	15	650	650	NUM
fnp-3806	544	16	,	,	PUNCT
fnp-3806	544	17	651	651	NUM
fnp-3806	544	18	)	)	PUNCT
fnp-3806	544	19	.	.	PUNCT
fnp-3806	545	1	a	a	DET
fnp-3806	545	2	few	few	ADJ
fnp-3806	545	3	studies	study	NOUN
fnp-3806	545	4	have	have	AUX
fnp-3806	545	5	shown	show	VERB
fnp-3806	545	6	altered	altered	ADJ
fnp-3806	545	7	expression	expression	NOUN
fnp-3806	545	8	levels	level	NOUN
fnp-3806	545	9	of	of	ADP
fnp-3806	545	10	endocannabinoids	endocannabinoid	NOUN
fnp-3806	545	11	and	and	CCONJ
fnp-3806	545	12	enzymes	enzyme	NOUN
fnp-3806	545	13	linked	link	VERB
fnp-3806	545	14	to	to	ADP
fnp-3806	545	15	their	their	PRON
fnp-3806	545	16	metabolism	metabolism	NOUN
fnp-3806	545	17	in	in	ADP
fnp-3806	545	18	sad	sad	ADJ
fnp-3806	545	19	(	(	PUNCT
fnp-3806	545	20	652	652	NUM
fnp-3806	545	21	-	-	NUM
fnp-3806	545	22	654	654	NUM
fnp-3806	545	23	)	)	PUNCT
fnp-3806	545	24	.	.	PUNCT
fnp-3806	546	1	therefore	therefore	ADV
fnp-3806	546	2	,	,	PUNCT
fnp-3806	546	3	the	the	DET
fnp-3806	546	4	endocannabinoid	endocannabinoid	NOUN
fnp-3806	546	5	system	system	NOUN
fnp-3806	546	6	plays	play	VERB
fnp-3806	546	7	a	a	DET
fnp-3806	546	8	role	role	NOUN
fnp-3806	546	9	in	in	ADP
fnp-3806	546	10	sad	sad	ADJ
fnp-3806	546	11	although	although	SCONJ
fnp-3806	546	12	its	its	PRON
fnp-3806	546	13	precise	precise	ADJ
fnp-3806	546	14	contribution	contribution	NOUN
fnp-3806	546	15	remains	remain	VERB
fnp-3806	546	16	largely	largely	ADV
fnp-3806	546	17	unknown	unknown	ADJ
fnp-3806	546	18	.	.	PUNCT
fnp-3806	547	1	treatment	treatment	NOUN
fnp-3806	547	2	with	with	ADP
fnp-3806	547	3	exogenous	exogenous	ADJ
fnp-3806	547	4	cannabinoids	cannabinoid	NOUN
fnp-3806	547	5	and	and	CCONJ
fnp-3806	547	6	modulation	modulation	NOUN
fnp-3806	547	7	of	of	ADP
fnp-3806	547	8	cbrs	cbrs	PROPN
fnp-3806	547	9	in	in	ADP
fnp-3806	547	10	murine	murine	ADJ
fnp-3806	547	11	models	model	NOUN
fnp-3806	547	12	of	of	ADP
fnp-3806	547	13	ad	ad	NOUN
fnp-3806	547	14	has	have	AUX
fnp-3806	547	15	shown	show	VERB
fnp-3806	547	16	beneficial	beneficial	ADJ
fnp-3806	547	17	effects	effect	NOUN
fnp-3806	547	18	including	include	VERB
fnp-3806	547	19	reduction	reduction	NOUN
fnp-3806	547	20	of	of	ADP
fnp-3806	547	21	β	β	NOUN
fnp-3806	547	22	-	-	ADJ
fnp-3806	547	23	amyloid	amyloid	ADJ
fnp-3806	547	24	plaques	plaque	NOUN
fnp-3806	547	25	and	and	CCONJ
fnp-3806	547	26	β	β	NOUN
fnp-3806	547	27	-	-	ADJ
fnp-3806	547	28	amyloid	amyloid	ADJ
fnp-3806	547	29	burden	burden	NOUN
fnp-3806	547	30	,	,	PUNCT
fnp-3806	547	31	reduced	reduce	VERB
fnp-3806	547	32	tau	tau	PROPN
fnp-3806	547	33	phosphorylation	phosphorylation	NOUN
fnp-3806	547	34	,	,	PUNCT
fnp-3806	547	35	reduced	reduce	VERB
fnp-3806	547	36	inflammation	inflammation	NOUN
fnp-3806	547	37	,	,	PUNCT
fnp-3806	547	38	excitoxicity	excitoxicity	NOUN
fnp-3806	547	39	,	,	PUNCT
fnp-3806	547	40	mitochondrial	mitochondrial	ADJ
fnp-3806	547	41	dysfunction	dysfunction	NOUN
fnp-3806	547	42	,	,	PUNCT
fnp-3806	547	43	and	and	CCONJ
fnp-3806	547	44	oxidative	oxidative	ADJ
fnp-3806	547	45	stress	stress	NOUN
fnp-3806	547	46	,	,	PUNCT
fnp-3806	547	47	and	and	CCONJ
fnp-3806	547	48	relief	relief	NOUN
fnp-3806	547	49	of	of	ADP
fnp-3806	547	50	cognitive	cognitive	ADJ
fnp-3806	547	51	impairment	impairment	NOUN
fnp-3806	547	52	(	(	PUNCT
fnp-3806	547	53	649	649	NUM
fnp-3806	547	54	)	)	PUNCT
fnp-3806	547	55	.	.	PUNCT
fnp-3806	548	1	8	8	X
fnp-3806	548	2	.	.	PUNCT
fnp-3806	548	3	trophic	trophic	ADJ
fnp-3806	548	4	factors	factor	NOUN
fnp-3806	548	5	and	and	CCONJ
fnp-3806	548	6	receptors	receptor	NOUN
fnp-3806	548	7	the	the	DET
fnp-3806	548	8	expression	expression	NOUN
fnp-3806	548	9	of	of	ADP
fnp-3806	548	10	trophic	trophic	ADJ
fnp-3806	548	11	factors	factor	NOUN
fnp-3806	548	12	,	,	PUNCT
fnp-3806	548	13	particularly	particularly	ADV
fnp-3806	548	14	brain	brain	NOUN
fnp-3806	548	15	-	-	PUNCT
fnp-3806	548	16	derived	derive	VERB
fnp-3806	548	17	neutrophic	neutrophic	ADJ
fnp-3806	548	18	factor	factor	NOUN
fnp-3806	548	19	(	(	PUNCT
fnp-3806	548	20	bdnf	bdnf	PROPN
fnp-3806	548	21	)	)	PUNCT
fnp-3806	548	22	and	and	CCONJ
fnp-3806	548	23	nerve	nerve	NOUN
fnp-3806	548	24	growth	growth	NOUN
fnp-3806	548	25	factor	factor	NOUN
fnp-3806	548	26	(	(	PUNCT
fnp-3806	548	27	ngf	ngf	NOUN
fnp-3806	548	28	)	)	PUNCT
fnp-3806	548	29	and	and	CCONJ
fnp-3806	548	30	their	their	PRON
fnp-3806	548	31	receptors	receptor	NOUN
fnp-3806	548	32	,	,	PUNCT
fnp-3806	548	33	is	be	AUX
fnp-3806	548	34	altered	alter	VERB
fnp-3806	548	35	in	in	ADP
fnp-3806	548	36	sad	sad	ADJ
fnp-3806	548	37	(	(	PUNCT
fnp-3806	548	38	655	655	NUM
fnp-3806	548	39	-	-	SYM
fnp-3806	548	40	659	659	NUM
fnp-3806	548	41	)	)	PUNCT
fnp-3806	548	42	.	.	PUNCT
fnp-3806	549	1	bdnf	bdnf	PROPN
fnp-3806	549	2	mrna	mrna	PROPN
fnp-3806	549	3	and	and	CCONJ
fnp-3806	549	4	protein	protein	NOUN
fnp-3806	549	5	are	be	AUX
fnp-3806	549	6	decreased	decrease	VERB
fnp-3806	549	7	in	in	ADP
fnp-3806	549	8	the	the	DET
fnp-3806	549	9	frontal	frontal	ADJ
fnp-3806	549	10	cortex	cortex	NOUN
fnp-3806	549	11	and	and	CCONJ
fnp-3806	549	12	hippocampus	hippocampus	NOUN
fnp-3806	549	13	in	in	ADP
fnp-3806	549	14	ad	ad	NOUN
fnp-3806	549	15	(	(	PUNCT
fnp-3806	549	16	660	660	NUM
fnp-3806	549	17	-	-	NUM
fnp-3806	549	18	662	662	NUM
fnp-3806	549	19	)	)	PUNCT
fnp-3806	549	20	.	.	PUNCT
fnp-3806	550	1	bdnf	bdnf	PROPN
fnp-3806	550	2	immunoreactivity	immunoreactivity	PROPN
fnp-3806	550	3	is	be	AUX
fnp-3806	550	4	reduced	reduce	VERB
fnp-3806	550	5	in	in	ADP
fnp-3806	550	6	tangle	tangle	NOUN
fnp-3806	550	7	-	-	PUNCT
fnp-3806	550	8	bearing	bearing	NOUN
fnp-3806	550	9	and	and	CCONJ
fnp-3806	550	10	non	non	ADJ
fnp-3806	550	11	-	-	ADJ
fnp-3806	550	12	tangle	tangle	ADJ
fnp-3806	550	13	-	-	PUNCT
fnp-3806	550	14	bearing	bear	VERB
fnp-3806	550	15	neurons	neuron	NOUN
fnp-3806	550	16	,	,	PUNCT
fnp-3806	550	17	whereas	whereas	SCONJ
fnp-3806	550	18	immunoreactivity	immunoreactivity	NOUN
fnp-3806	550	19	to	to	ADP
fnp-3806	550	20	full	full	ADJ
fnp-3806	550	21	-	-	PUNCT
fnp-3806	550	22	length	length	NOUN
fnp-3806	550	23	trkb	trkb	NOUN
fnp-3806	550	24	(	(	PUNCT
fnp-3806	550	25	the	the	DET
fnp-3806	550	26	high	high	ADJ
fnp-3806	550	27	affinity	affinity	NOUN
fnp-3806	550	28	receptor	receptor	NOUN
fnp-3806	550	29	for	for	ADP
fnp-3806	550	30	bdnf	bdnf	PROPN
fnp-3806	550	31	,	,	PUNCT
fnp-3806	550	32	neurotrophin-3	neurotrophin-3	PROPN
fnp-3806	550	33	and	and	CCONJ
fnp-3806	550	34	neurotrophin-4	neurotrophin-4	NUM
fnp-3806	550	35	)	)	PUNCT
fnp-3806	550	36	is	be	AUX
fnp-3806	550	37	reduced	reduce	VERB
fnp-3806	550	38	in	in	ADP
fnp-3806	550	39	tangle	tangle	NOUN
fnp-3806	550	40	-	-	PUNCT
fnp-3806	550	41	bearing	bear	VERB
fnp-3806	550	42	neurons	neuron	NOUN
fnp-3806	550	43	.	.	PUNCT
fnp-3806	551	1	strong	strong	ADJ
fnp-3806	551	2	bdnf	bdnf	ADJ
fnp-3806	551	3	immunoreactivity	immunoreactivity	NOUN
fnp-3806	551	4	is	be	AUX
fnp-3806	551	5	observed	observe	VERB
fnp-3806	551	6	in	in	ADP
fnp-3806	551	7	dystrophic	dystrophic	ADJ
fnp-3806	551	8	neurites	neurite	NOUN
fnp-3806	551	9	surrounding	surround	VERB
fnp-3806	551	10	sps	sps	NOUN
fnp-3806	551	11	,	,	PUNCT
fnp-3806	551	12	and	and	CCONJ
fnp-3806	551	13	strong	strong	ADJ
fnp-3806	551	14	trkb	trkb	NOUN
fnp-3806	551	15	in	in	ADP
fnp-3806	551	16	reactive	reactive	ADJ
fnp-3806	551	17	glial	glial	ADJ
fnp-3806	551	18	cells	cell	NOUN
fnp-3806	551	19	,	,	PUNCT
fnp-3806	551	20	including	include	VERB
fnp-3806	551	21	those	those	PRON
fnp-3806	551	22	surrounding	surround	VERB
fnp-3806	551	23	sps	sps	PROPN
fnp-3806	551	24	.	.	PUNCT
fnp-3806	552	1	truncated	truncate	VERB
fnp-3806	552	2	trkb	trkb	NOUN
fnp-3806	552	3	immunoreactivity	immunoreactivity	NOUN
fnp-3806	552	4	occurs	occur	VERB
fnp-3806	552	5	in	in	ADP
fnp-3806	552	6	individual	individual	ADJ
fnp-3806	552	7	neurons	neuron	NOUN
fnp-3806	552	8	and	and	CCONJ
fnp-3806	552	9	reactive	reactive	ADJ
fnp-3806	552	10	glial	glial	ADJ
fnp-3806	552	11	cells	cell	NOUN
fnp-3806	552	12	in	in	ADP
fnp-3806	552	13	the	the	DET
fnp-3806	552	14	cerebral	cerebral	ADJ
fnp-3806	552	15	cortex	cortex	NOUN
fnp-3806	552	16	and	and	CCONJ
fnp-3806	552	17	white	white	ADJ
fnp-3806	552	18	matter	matter	NOUN
fnp-3806	552	19	in	in	ADP
fnp-3806	552	20	sad	sad	ADJ
fnp-3806	552	21	(	(	PUNCT
fnp-3806	552	22	661	661	NUM
fnp-3806	552	23	)	)	PUNCT
fnp-3806	552	24	.	.	PUNCT
fnp-3806	553	1	the	the	DET
fnp-3806	553	2	cause	cause	NOUN
fnp-3806	553	3	of	of	ADP
fnp-3806	553	4	abnormal	abnormal	ADJ
fnp-3806	553	5	trkb	trkb	NOUN
fnp-3806	553	6	immunoreactivity	immunoreactivity	NOUN
fnp-3806	553	7	in	in	ADP
fnp-3806	553	8	sad	sad	ADJ
fnp-3806	553	9	is	be	AUX
fnp-3806	553	10	not	not	PART
fnp-3806	553	11	known	know	VERB
fnp-3806	553	12	but	but	CCONJ
fnp-3806	553	13	β	β	ADJ
fnp-3806	553	14	-	-	ADJ
fnp-3806	553	15	amyloid	amyloid	ADJ
fnp-3806	553	16	modulates	modulate	NOUN
fnp-3806	553	17	trkb	trkb	NOUN
fnp-3806	553	18	alternative	alternative	ADJ
fnp-3806	553	19	transcript	transcript	NOUN
fnp-3806	553	20	expression	expression	NOUN
fnp-3806	553	21	(	(	PUNCT
fnp-3806	553	22	663	663	NUM
fnp-3806	553	23	)	)	PUNCT
fnp-3806	553	24	.	.	PUNCT
fnp-3806	554	1	probdnf	probdnf	PROPN
fnp-3806	554	2	is	be	AUX
fnp-3806	554	3	increased	increase	VERB
fnp-3806	554	4	in	in	ADP
fnp-3806	554	5	sad	sad	ADJ
fnp-3806	554	6	,	,	PUNCT
fnp-3806	554	7	and	and	CCONJ
fnp-3806	554	8	it	it	PRON
fnp-3806	554	9	is	be	AUX
fnp-3806	554	10	modified	modify	VERB
fnp-3806	554	11	by	by	ADP
fnp-3806	554	12	reactive	reactive	ADJ
fnp-3806	554	13	oxygen	oxygen	NOUN
fnp-3806	554	14	species	specie	NOUN
fnp-3806	554	15	(	(	PUNCT
fnp-3806	554	16	ros)-derived	ros)-derive	VERB
fnp-3806	554	17	advanced	advanced	ADJ
fnp-3806	554	18	glycation	glycation	NOUN
fnp-3806	554	19	end	end	NOUN
fnp-3806	554	20	products	product	NOUN
fnp-3806	554	21	,	,	PUNCT
fnp-3806	554	22	which	which	PRON
fnp-3806	554	23	prevent	prevent	VERB
fnp-3806	554	24	the	the	DET
fnp-3806	554	25	processing	processing	NOUN
fnp-3806	554	26	of	of	ADP
fnp-3806	554	27	probdnf	probdnf	NOUN
fnp-3806	554	28	to	to	PART
fnp-3806	554	29	mature	mature	VERB
fnp-3806	554	30	bdnf	bdnf	PROPN
fnp-3806	554	31	(	(	PUNCT
fnp-3806	554	32	664	664	NUM
fnp-3806	554	33	)	)	PUNCT
fnp-3806	554	34	.	.	PUNCT
fnp-3806	555	1	abnormal	abnormal	ADJ
fnp-3806	555	2	probdnf	probdnf	NOUN
fnp-3806	555	3	/	/	SYM
fnp-3806	555	4	bdnf	bdnf	PROPN
fnp-3806	555	5	signaling	signal	VERB
fnp-3806	555	6	impairs	impair	VERB
fnp-3806	555	7	axonal	axonal	ADJ
fnp-3806	555	8	transport	transport	NOUN
fnp-3806	555	9	,	,	PUNCT
fnp-3806	555	10	decreases	decrease	VERB
fnp-3806	555	11	trophic	trophic	ADJ
fnp-3806	555	12	effects	effect	NOUN
fnp-3806	555	13	,	,	PUNCT
fnp-3806	555	14	and	and	CCONJ
fnp-3806	555	15	increases	increase	VERB
fnp-3806	555	16	pathogenicity	pathogenicity	NOUN
fnp-3806	555	17	and	and	CCONJ
fnp-3806	555	18	cell	cell	NOUN
fnp-3806	555	19	death	death	NOUN
fnp-3806	555	20	(	(	PUNCT
fnp-3806	555	21	661	661	NUM
fnp-3806	555	22	,	,	PUNCT
fnp-3806	555	23	664	664	NUM
fnp-3806	555	24	,	,	PUNCT
fnp-3806	555	25	665	665	NUM
fnp-3806	555	26	)	)	PUNCT
fnp-3806	555	27	.	.	PUNCT
fnp-3806	556	1	in	in	ADP
fnp-3806	556	2	contrast	contrast	NOUN
fnp-3806	556	3	,	,	PUNCT
fnp-3806	556	4	the	the	DET
fnp-3806	556	5	expression	expression	NOUN
fnp-3806	556	6	of	of	ADP
fnp-3806	556	7	ngf	ngf	ADV
fnp-3806	556	8	is	be	AUX
fnp-3806	556	9	increased	increase	VERB
fnp-3806	556	10	in	in	ADP
fnp-3806	556	11	sad	sad	ADJ
fnp-3806	556	12	(	(	PUNCT
fnp-3806	556	13	655	655	NUM
fnp-3806	556	14	,	,	PUNCT
fnp-3806	556	15	666	666	NUM
fnp-3806	556	16	)	)	PUNCT
fnp-3806	556	17	,	,	PUNCT
fnp-3806	556	18	but	but	CCONJ
fnp-3806	556	19	ngf	ngf	ADV
fnp-3806	556	20	-	-	PUNCT
fnp-3806	556	21	containing	contain	VERB
fnp-3806	556	22	neurons	neuron	NOUN
fnp-3806	556	23	in	in	ADP
fnp-3806	556	24	the	the	DET
fnp-3806	556	25	basal	basal	ADJ
fnp-3806	556	26	forebrain	forebrain	NOUN
fnp-3806	556	27	are	be	AUX
fnp-3806	556	28	lost	lose	VERB
fnp-3806	556	29	in	in	ADP
fnp-3806	556	30	sad	sad	ADJ
fnp-3806	556	31	(	(	PUNCT
fnp-3806	556	32	454	454	NUM
fnp-3806	556	33	,	,	PUNCT
fnp-3806	556	34	667	667	NUM
fnp-3806	556	35	)	)	PUNCT
fnp-3806	556	36	.	.	PUNCT
fnp-3806	557	1	prongf	prongf	PROPN
fnp-3806	557	2	is	be	AUX
fnp-3806	557	3	also	also	ADV
fnp-3806	557	4	increased	increase	VERB
fnp-3806	557	5	in	in	ADP
fnp-3806	557	6	sad	sad	ADJ
fnp-3806	557	7	(	(	PUNCT
fnp-3806	557	8	668	668	NUM
fnp-3806	557	9	,	,	PUNCT
fnp-3806	557	10	669	669	NUM
fnp-3806	557	11	)	)	PUNCT
fnp-3806	557	12	.	.	PUNCT
fnp-3806	558	1	this	this	PRON
fnp-3806	558	2	has	have	VERB
fnp-3806	558	3	relevant	relevant	ADJ
fnp-3806	558	4	implications	implication	NOUN
fnp-3806	558	5	as	as	SCONJ
fnp-3806	558	6	prongf	prongf	NOUN
fnp-3806	558	7	induces	induce	VERB
fnp-3806	558	8	processing	processing	NOUN
fnp-3806	558	9	and	and	CCONJ
fnp-3806	558	10	nuclear	nuclear	ADJ
fnp-3806	558	11	translocation	translocation	NOUN
fnp-3806	558	12	of	of	ADP
fnp-3806	558	13	the	the	DET
fnp-3806	558	14	intracellular	intracellular	ADJ
fnp-3806	558	15	domain	domain	NOUN
fnp-3806	558	16	of	of	ADP
fnp-3806	558	17	p75ntr	p75ntr	PROPN
fnp-3806	558	18	(	(	PUNCT
fnp-3806	558	19	the	the	DET
fnp-3806	558	20	low	low	ADJ
fnp-3806	558	21	affinity	affinity	NOUN
fnp-3806	558	22	neurotrophin	neurotrophin	NOUN
fnp-3806	558	23	receptor	receptor	NOUN
fnp-3806	558	24	for	for	ADP
fnp-3806	558	25	ngf	ngf	ADV
fnp-3806	558	26	,	,	PUNCT
fnp-3806	558	27	bdnf	bdnf	PROPN
fnp-3806	558	28	,	,	PUNCT
fnp-3806	558	29	neurotrophin	neurotrophin	NOUN
fnp-3806	558	30	3	3	NUM
fnp-3806	558	31	,	,	PUNCT
fnp-3806	558	32	and	and	CCONJ
fnp-3806	558	33	neurotrophin	neurotrophin	PROPN
fnp-3806	558	34	4	4	NUM
fnp-3806	558	35	)	)	PUNCT
fnp-3806	558	36	and	and	CCONJ
fnp-3806	558	37	induces	induce	VERB
fnp-3806	558	38	cell	cell	NOUN
fnp-3806	558	39	death	death	NOUN
fnp-3806	558	40	in	in	ADP
fnp-3806	558	41	association	association	NOUN
fnp-3806	558	42	with	with	ADP
fnp-3806	558	43	cofactor	cofactor	NOUN
fnp-3806	558	44	sortilin	sortilin	PROPN
fnp-3806	558	45	,	,	PUNCT
fnp-3806	558	46	a	a	DET
fnp-3806	558	47	member	member	NOUN
fnp-3806	558	48	of	of	ADP
fnp-3806	558	49	the	the	DET
fnp-3806	558	50	vps10p	vps10p	NOUN
fnp-3806	558	51	sorting	sort	VERB
fnp-3806	558	52	receptor	receptor	NOUN
fnp-3806	558	53	family	family	NOUN
fnp-3806	558	54	(	(	PUNCT
fnp-3806	558	55	670	670	NUM
fnp-3806	558	56	-	-	SYM
fnp-3806	558	57	672	672	NUM
fnp-3806	558	58	)	)	PUNCT
fnp-3806	558	59	.	.	PUNCT
fnp-3806	559	1	9	9	X
fnp-3806	559	2	.	.	X
fnp-3806	559	3	endoplasmic	endoplasmic	ADJ
fnp-3806	559	4	reticulum	reticulum	NOUN
fnp-3806	559	5	stress	stress	VERB
fnp-3806	559	6	the	the	DET
fnp-3806	559	7	accumulation	accumulation	NOUN
fnp-3806	559	8	of	of	ADP
fnp-3806	559	9	abnormally	abnormally	ADV
fnp-3806	559	10	misfolded	misfolde	VERB
fnp-3806	559	11	proteins	protein	NOUN
fnp-3806	559	12	in	in	ADP
fnp-3806	559	13	the	the	DET
fnp-3806	559	14	endoplasmic	endoplasmic	ADJ
fnp-3806	559	15	reticulum	reticulum	NOUN
fnp-3806	559	16	(	(	PUNCT
fnp-3806	559	17	er	er	INTJ
fnp-3806	559	18	)	)	PUNCT
fnp-3806	559	19	causes	cause	VERB
fnp-3806	559	20	er	er	INTJ
fnp-3806	559	21	stress	stress	NOUN
fnp-3806	559	22	which	which	PRON
fnp-3806	559	23	is	be	AUX
fnp-3806	559	24	manifested	manifest	VERB
fnp-3806	559	25	by	by	ADP
fnp-3806	559	26	activation	activation	NOUN
fnp-3806	559	27	of	of	ADP
fnp-3806	559	28	one	one	NUM
fnp-3806	559	29	or	or	CCONJ
fnp-3806	559	30	more	more	ADJ
fnp-3806	559	31	of	of	ADP
fnp-3806	559	32	the	the	DET
fnp-3806	559	33	three	three	NUM
fnp-3806	559	34	signaling	signal	VERB
fnp-3806	559	35	pathways	pathway	NOUN
fnp-3806	559	36	of	of	ADP
fnp-3806	559	37	the	the	DET
fnp-3806	559	38	misfolded	misfolde	VERB
fnp-3806	559	39	protein	protein	NOUN
fnp-3806	559	40	response	response	NOUN
fnp-3806	559	41	(	(	PUNCT
fnp-3806	559	42	upr	upr	NOUN
fnp-3806	559	43	)	)	PUNCT
fnp-3806	559	44	(	(	PUNCT
fnp-3806	559	45	673	673	NUM
fnp-3806	559	46	)	)	PUNCT
fnp-3806	559	47	.	.	PUNCT
fnp-3806	560	1	glucose	glucose	NOUN
fnp-3806	560	2	-	-	PUNCT
fnp-3806	560	3	related	relate	VERB
fnp-3806	560	4	protein	protein	NOUN
fnp-3806	560	5	78	78	NUM
fnp-3806	560	6	(	(	PUNCT
fnp-3806	560	7	grp78	grp78	PROPN
fnp-3806	560	8	/	/	SYM
fnp-3806	560	9	bip	bip	PROPN
fnp-3806	560	10	)	)	PUNCT
fnp-3806	560	11	is	be	AUX
fnp-3806	560	12	the	the	DET
fnp-3806	560	13	master	master	NOUN
fnp-3806	560	14	protein	protein	NOUN
fnp-3806	560	15	that	that	PRON
fnp-3806	560	16	regulates	regulate	VERB
fnp-3806	560	17	the	the	DET
fnp-3806	560	18	upr	upr	NOUN
fnp-3806	560	19	(	(	PUNCT
fnp-3806	560	20	674	674	NUM
fnp-3806	560	21	)	)	PUNCT
fnp-3806	560	22	.	.	PUNCT
fnp-3806	561	1	the	the	DET
fnp-3806	561	2	cytosolic	cytosolic	ADJ
fnp-3806	561	3	domains	domain	NOUN
fnp-3806	561	4	of	of	ADP
fnp-3806	561	5	the	the	DET
fnp-3806	561	6	transmembrane	transmembrane	NOUN
fnp-3806	561	7	er	er	INTJ
fnp-3806	561	8	proteins	protein	NOUN
fnp-3806	561	9	pkr	pkr	NOUN
fnp-3806	561	10	-	-	PUNCT
fnp-3806	561	11	like	like	ADJ
fnp-3806	561	12	endoplasmic	endoplasmic	ADJ
fnp-3806	561	13	reticulum	reticulum	NOUN
fnp-3806	561	14	kinase	kinase	NOUN
fnp-3806	561	15	(	(	PUNCT
fnp-3806	561	16	perk	perk	NOUN
fnp-3806	561	17	)	)	PUNCT
fnp-3806	561	18	,	,	PUNCT
fnp-3806	561	19	inositol	inositol	NOUN
fnp-3806	561	20	-	-	PUNCT
fnp-3806	561	21	requiring	require	VERB
fnp-3806	561	22	protein	protein	NOUN
fnp-3806	561	23	1	1	NUM
fnp-3806	561	24	(	(	PUNCT
fnp-3806	561	25	ire1	ire1	PROPN
fnp-3806	561	26	)	)	PUNCT
fnp-3806	561	27	,	,	PUNCT
fnp-3806	561	28	and	and	CCONJ
fnp-3806	561	29	activating	activate	VERB
fnp-3806	561	30	transcription	transcription	NOUN
fnp-3806	561	31	factor	factor	NOUN
fnp-3806	561	32	(	(	PUNCT
fnp-3806	561	33	atf)-6	atf)-6	ADV
fnp-3806	561	34	,	,	PUNCT
fnp-3806	561	35	trigger	trigger	VERB
fnp-3806	561	36	specific	specific	ADJ
fnp-3806	561	37	pathways	pathway	NOUN
fnp-3806	561	38	once	once	ADV
fnp-3806	561	39	activated	activate	VERB
fnp-3806	561	40	.	.	PUNCT
fnp-3806	562	1	perk	perk	NOUN
fnp-3806	562	2	activates	activate	VERB
fnp-3806	562	3	atf-4	atf-4	NUM
fnp-3806	562	4	,	,	PUNCT
fnp-3806	562	5	and	and	CCONJ
fnp-3806	562	6	the	the	DET
fnp-3806	562	7	activation	activation	NOUN
fnp-3806	562	8	of	of	ADP
fnp-3806	562	9	atf6	atf6	PROPN
fnp-3806	562	10	involves	involve	VERB
fnp-3806	562	11	its	its	PRON
fnp-3806	562	12	displacement	displacement	NOUN
fnp-3806	562	13	from	from	ADP
fnp-3806	562	14	the	the	DET
fnp-3806	562	15	er	er	INTJ
fnp-3806	562	16	to	to	ADP
fnp-3806	562	17	the	the	DET
fnp-3806	562	18	golgi	golgi	NOUN
fnp-3806	562	19	apparatus	apparatus	NOUN
fnp-3806	562	20	to	to	PART
fnp-3806	562	21	be	be	AUX
fnp-3806	562	22	cleaved	cleave	VERB
fnp-3806	562	23	into	into	ADP
fnp-3806	562	24	atf6c	atf6c	PROPN
fnp-3806	562	25	.	.	PUNCT
fnp-3806	563	1	ire1	ire1	PROPN
fnp-3806	563	2	dimers	dimer	NOUN
fnp-3806	563	3	phosphorylate	phosphorylate	VERB
fnp-3806	563	4	and	and	CCONJ
fnp-3806	563	5	lead	lead	VERB
fnp-3806	563	6	to	to	ADP
fnp-3806	563	7	the	the	DET
fnp-3806	563	8	production	production	NOUN
fnp-3806	563	9	of	of	ADP
fnp-3806	563	10	x	x	NOUN
fnp-3806	563	11	-	-	NOUN
fnp-3806	563	12	box	box	NOUN
fnp-3806	563	13	binding	bind	VERB
fnp-3806	563	14	protein	protein	NOUN
fnp-3806	563	15	1	1	NUM
fnp-3806	563	16	(	(	PUNCT
fnp-3806	563	17	xbp-1	xbp-1	X
fnp-3806	563	18	)	)	PUNCT
fnp-3806	563	19	which	which	PRON
fnp-3806	563	20	increases	increase	VERB
fnp-3806	563	21	the	the	DET
fnp-3806	563	22	er	er	INTJ
fnp-3806	563	23	capacity	capacity	NOUN
fnp-3806	563	24	of	of	ADP
fnp-3806	563	25	protein	protein	NOUN
fnp-3806	563	26	folding	folding	NOUN
fnp-3806	563	27	and	and	CCONJ
fnp-3806	563	28	the	the	DET
fnp-3806	563	29	degradation	degradation	NOUN
fnp-3806	563	30	of	of	ADP
fnp-3806	563	31	abnormally	abnormally	ADV
fnp-3806	563	32	folded	fold	VERB
fnp-3806	563	33	proteins	protein	NOUN
fnp-3806	563	34	in	in	ADP
fnp-3806	563	35	the	the	DET
fnp-3806	563	36	er	er	INTJ
fnp-3806	563	37	,	,	PUNCT
fnp-3806	563	38	thus	thus	ADV
fnp-3806	563	39	reducing	reduce	VERB
fnp-3806	563	40	er	er	INTJ
fnp-3806	563	41	stress	stress	NOUN
fnp-3806	563	42	.	.	PUNCT
fnp-3806	564	1	ire1	ire1	PROPN
fnp-3806	564	2	may	may	AUX
fnp-3806	564	3	also	also	ADV
fnp-3806	564	4	bind	bind	VERB
fnp-3806	564	5	to	to	ADP
fnp-3806	564	6	the	the	DET
fnp-3806	564	7	traf2	traf2	PROPN
fnp-3806	564	8	(	(	PUNCT
fnp-3806	564	9	tnf	tnf	PROPN
fnp-3806	564	10	receptor	receptor	NOUN
fnp-3806	564	11	-	-	PUNCT
fnp-3806	564	12	associated	associate	VERB
fnp-3806	564	13	factor	factor	NOUN
fnp-3806	564	14	2	2	NUM
fnp-3806	564	15	)	)	PUNCT
fnp-3806	564	16	adaptor	adaptor	NOUN
fnp-3806	564	17	molecule	molecule	NOUN
fnp-3806	564	18	and	and	CCONJ
fnp-3806	564	19	activate	activate	VERB
fnp-3806	564	20	the	the	DET
fnp-3806	564	21	apoptosis	apoptosis	NOUN
fnp-3806	564	22	signal	signal	NOUN
fnp-3806	564	23	-	-	PUNCT
fnp-3806	564	24	regulating	regulate	VERB
fnp-3806	564	25	kinase	kinase	NOUN
fnp-3806	564	26	1	1	NUM
fnp-3806	564	27	(	(	PUNCT
fnp-3806	564	28	ask1	ask1	NOUN
fnp-3806	564	29	)	)	PUNCT
fnp-3806	564	30	,	,	PUNCT
fnp-3806	564	31	which	which	PRON
fnp-3806	564	32	in	in	ADP
fnp-3806	564	33	turn	turn	NOUN
fnp-3806	564	34	causes	cause	VERB
fnp-3806	564	35	the	the	DET
fnp-3806	564	36	phosphorylation	phosphorylation	NOUN
fnp-3806	564	37	of	of	ADP
fnp-3806	564	38	c	c	PROPN
fnp-3806	564	39	-	-	PUNCT
fnp-3806	564	40	jun	jun	PROPN
fnp-3806	564	41	n	n	CCONJ
fnp-3806	564	42	-	-	PUNCT
fnp-3806	564	43	terminal	terminal	ADJ
fnp-3806	564	44	kinase	kinase	NOUN
fnp-3806	564	45	(	(	PUNCT
fnp-3806	564	46	jnk	jnk	PROPN
fnp-3806	564	47	)	)	PUNCT
fnp-3806	564	48	,	,	PUNCT
fnp-3806	564	49	thereby	thereby	ADV
fnp-3806	564	50	triggering	trigger	VERB
fnp-3806	564	51	cell	cell	NOUN
fnp-3806	564	52	death	death	NOUN
fnp-3806	564	53	.	.	PUNCT
fnp-3806	565	1	atf-4	atf-4	NUM
fnp-3806	565	2	,	,	PUNCT
fnp-3806	565	3	truncated	truncate	VERB
fnp-3806	565	4	atf6	atf6	PROPN
fnp-3806	565	5	,	,	PUNCT
fnp-3806	565	6	and	and	CCONJ
fnp-3806	565	7	xbp-1	xbp-1	ADV
fnp-3806	565	8	,	,	PUNCT
fnp-3806	565	9	through	through	ADP
fnp-3806	565	10	downstream	downstream	ADJ
fnp-3806	565	11	target	target	NOUN
fnp-3806	565	12	genes	gene	NOUN
fnp-3806	565	13	,	,	PUNCT
fnp-3806	565	14	modulate	modulate	VERB
fnp-3806	565	15	er	er	INTJ
fnp-3806	565	16	homeostasis	homeostasis	NOUN
fnp-3806	565	17	or	or	CCONJ
fnp-3806	565	18	apoptosis	apoptosis	NOUN
fnp-3806	565	19	,	,	PUNCT
fnp-3806	565	20	depending	depend	VERB
fnp-3806	565	21	on	on	ADP
fnp-3806	565	22	the	the	DET
fnp-3806	565	23	saturation	saturation	NOUN
fnp-3806	565	24	of	of	ADP
fnp-3806	565	25	the	the	DET
fnp-3806	565	26	system	system	NOUN
fnp-3806	565	27	(	(	PUNCT
fnp-3806	565	28	673	673	NUM
fnp-3806	565	29	,	,	PUNCT
fnp-3806	565	30	675	675	NUM
fnp-3806	565	31	)	)	PUNCT
fnp-3806	565	32	.	.	PUNCT
fnp-3806	566	1	the	the	DET
fnp-3806	566	2	expression	expression	NOUN
fnp-3806	566	3	of	of	ADP
fnp-3806	566	4	several	several	ADJ
fnp-3806	566	5	upr	upr	ADJ
fnp-3806	566	6	components	component	NOUN
fnp-3806	566	7	is	be	AUX
fnp-3806	566	8	altered	alter	VERB
fnp-3806	566	9	in	in	ADP
fnp-3806	566	10	aging	age	VERB
fnp-3806	566	11	and	and	CCONJ
fnp-3806	566	12	sad	sad	ADJ
fnp-3806	566	13	(	(	PUNCT
fnp-3806	566	14	676	676	NUM
fnp-3806	566	15	-	-	NUM
fnp-3806	566	16	679	679	NUM
fnp-3806	566	17	)	)	PUNCT
fnp-3806	566	18	.	.	PUNCT
fnp-3806	567	1	er	er	INTJ
fnp-3806	567	2	stress	stress	NOUN
fnp-3806	567	3	also	also	ADV
fnp-3806	567	4	generates	generate	VERB
fnp-3806	567	5	ros	ros	PROPN
fnp-3806	567	6	which	which	PRON
fnp-3806	567	7	,	,	PUNCT
fnp-3806	567	8	together	together	ADV
fnp-3806	567	9	with	with	ADP
fnp-3806	567	10	mitochondrial	mitochondrial	ADJ
fnp-3806	567	11	ros	ro	NOUN
fnp-3806	567	12	,	,	PUNCT
fnp-3806	567	13	is	be	AUX
fnp-3806	567	14	a	a	DET
fnp-3806	567	15	major	major	ADJ
fnp-3806	567	16	cause	cause	NOUN
fnp-3806	567	17	of	of	ADP
fnp-3806	567	18	oxidative	oxidative	ADJ
fnp-3806	567	19	stress	stress	NOUN
fnp-3806	567	20	damage	damage	NOUN
fnp-3806	567	21	.	.	PUNCT
fnp-3806	568	1	mitochondrial	mitochondrial	ADJ
fnp-3806	568	2	dysfunction	dysfunction	NOUN
fnp-3806	568	3	and	and	CCONJ
fnp-3806	568	4	er	er	INTJ
fnp-3806	568	5	stress	stress	NOUN
fnp-3806	568	6	are	be	AUX
fnp-3806	568	7	relevant	relevant	ADJ
fnp-3806	568	8	promoters	promoter	NOUN
fnp-3806	568	9	of	of	ADP
fnp-3806	568	10	apoptosis	apoptosis	NOUN
fnp-3806	568	11	in	in	ADP
fnp-3806	568	12	sad	sad	ADJ
fnp-3806	568	13	(	(	PUNCT
fnp-3806	568	14	680	680	NUM
fnp-3806	568	15	)	)	PUNCT
fnp-3806	568	16	.	.	PUNCT
fnp-3806	569	1	er	er	INTJ
fnp-3806	569	2	stress	stress	NOUN
fnp-3806	569	3	is	be	AUX
fnp-3806	569	4	also	also	ADV
fnp-3806	569	5	linked	link	VERB
fnp-3806	569	6	to	to	ADP
fnp-3806	569	7	brain	brain	NOUN
fnp-3806	569	8	inflammation	inflammation	NOUN
fnp-3806	569	9	(	(	PUNCT
fnp-3806	569	10	681	681	NUM
fnp-3806	569	11	,	,	PUNCT
fnp-3806	569	12	682	682	NUM
fnp-3806	569	13	)	)	PUNCT
fnp-3806	569	14	.	.	PUNCT
fnp-3806	570	1	moreover	moreover	ADV
fnp-3806	570	2	,	,	PUNCT
fnp-3806	570	3	β	β	X
fnp-3806	570	4	-	-	NOUN
fnp-3806	570	5	amyloid	amyloid	NOUN
fnp-3806	570	6	may	may	AUX
fnp-3806	570	7	activate	activate	VERB
fnp-3806	570	8	the	the	DET
fnp-3806	570	9	upr	upr	NOUN
fnp-3806	570	10	,	,	PUNCT
fnp-3806	570	11	either	either	CCONJ
fnp-3806	570	12	mediated	mediate	VERB
fnp-3806	570	13	by	by	ADP
fnp-3806	570	14	glutamate	glutamate	NOUN
fnp-3806	570	15	receptors	receptor	NOUN
fnp-3806	570	16	and	and	CCONJ
fnp-3806	570	17	calcium	calcium	NOUN
fnp-3806	570	18	uptake	uptake	NOUN
fnp-3806	570	19	,	,	PUNCT
fnp-3806	570	20	or	or	CCONJ
fnp-3806	570	21	linked	link	VERB
fnp-3806	570	22	to	to	ADP
fnp-3806	570	23	mitochondrial	mitochondrial	ADJ
fnp-3806	570	24	dysfunction	dysfunction	NOUN
fnp-3806	570	25	and	and	CCONJ
fnp-3806	570	26	ros	ros	PROPN
fnp-3806	570	27	production	production	NOUN
fnp-3806	570	28	;	;	PUNCT
fnp-3806	570	29	er	er	INTJ
fnp-3806	570	30	stress	stress	NOUN
fnp-3806	570	31	may	may	AUX
fnp-3806	570	32	also	also	ADV
fnp-3806	570	33	be	be	AUX
fnp-3806	570	34	induced	induce	VERB
fnp-3806	570	35	by	by	ADP
fnp-3806	570	36	abnormal	abnormal	ADJ
fnp-3806	570	37	tau	tau	PROPN
fnp-3806	570	38	(	(	PUNCT
fnp-3806	570	39	683	683	NUM
fnp-3806	570	40	-	-	SYM
fnp-3806	570	41	685	685	NUM
fnp-3806	570	42	)	)	PUNCT
fnp-3806	570	43	.	.	PUNCT
fnp-3806	571	1	moreover	moreover	ADV
fnp-3806	571	2	,	,	PUNCT
fnp-3806	571	3	perk	perk	NOUN
fnp-3806	571	4	,	,	PUNCT
fnp-3806	571	5	ire1	ire1	PROPN
fnp-3806	571	6	and	and	CCONJ
fnp-3806	571	7	atf6	atf6	PROPN
fnp-3806	571	8	signaling	signal	VERB
fnp-3806	571	9	pathways	pathway	NOUN
fnp-3806	571	10	activate	activate	VERB
fnp-3806	571	11	autophagy	autophagy	NOUN
fnp-3806	571	12	(	(	PUNCT
fnp-3806	571	13	686	686	NUM
fnp-3806	571	14	-	-	SYM
fnp-3806	571	15	688	688	NUM
fnp-3806	571	16	)	)	PUNCT
fnp-3806	571	17	.	.	PUNCT
fnp-3806	572	1	10	10	NUM
fnp-3806	572	2	.	.	PUNCT
fnp-3806	572	3	failure	failure	NOUN
fnp-3806	572	4	to	to	PART
fnp-3806	572	5	remove	remove	VERB
fnp-3806	572	6	debris	debris	NOUN
fnp-3806	572	7	:	:	PUNCT
fnp-3806	572	8	the	the	DET
fnp-3806	572	9	ubiquitin	ubiquitin	ADJ
fnp-3806	572	10	-	-	PUNCT
fnp-3806	572	11	proteasome	proteasome	NOUN
fnp-3806	572	12	system	system	NOUN
fnp-3806	572	13	(	(	PUNCT
fnp-3806	572	14	ups	up	NOUN
fnp-3806	572	15	)	)	PUNCT
fnp-3806	572	16	and	and	CCONJ
fnp-3806	572	17	autophagy	autophagy	VERB
fnp-3806	572	18	in	in	ADP
fnp-3806	572	19	sad	sad	ADJ
fnp-3806	572	20	autophagy	autophagy	NOUN
fnp-3806	572	21	and	and	CCONJ
fnp-3806	572	22	ups	up	NOUN
fnp-3806	572	23	are	be	AUX
fnp-3806	572	24	the	the	DET
fnp-3806	572	25	two	two	NUM
fnp-3806	572	26	main	main	ADJ
fnp-3806	572	27	mechanisms	mechanism	NOUN
fnp-3806	572	28	of	of	ADP
fnp-3806	572	29	intracellular	intracellular	ADJ
fnp-3806	572	30	protein	protein	NOUN
fnp-3806	572	31	degradation	degradation	NOUN
fnp-3806	572	32	.	.	PUNCT
fnp-3806	573	1	there	there	PRON
fnp-3806	573	2	is	be	VERB
fnp-3806	573	3	a	a	DET
fnp-3806	573	4	certain	certain	ADJ
fnp-3806	573	5	relationship	relationship	NOUN
fnp-3806	573	6	between	between	ADP
fnp-3806	573	7	these	these	DET
fnp-3806	573	8	two	two	NUM
fnp-3806	573	9	mechanisms	mechanism	NOUN
fnp-3806	573	10	,	,	PUNCT
fnp-3806	573	11	and	and	CCONJ
fnp-3806	573	12	there	there	PRON
fnp-3806	573	13	are	be	VERB
fnp-3806	573	14	some	some	DET
fnp-3806	573	15	molecules	molecule	NOUN
fnp-3806	573	16	in	in	ADP
fnp-3806	573	17	common	common	ADJ
fnp-3806	573	18	that	that	PRON
fnp-3806	573	19	initiate	initiate	VERB
fnp-3806	573	20	compensatory	compensatory	ADJ
fnp-3806	573	21	effects	effect	NOUN
fnp-3806	573	22	to	to	PART
fnp-3806	573	23	prevent	prevent	VERB
fnp-3806	573	24	disease	disease	NOUN
fnp-3806	573	25	progression	progression	NOUN
fnp-3806	573	26	(	(	PUNCT
fnp-3806	573	27	689	689	NUM
fnp-3806	573	28	,	,	PUNCT
fnp-3806	573	29	690	690	NUM
fnp-3806	573	30	)	)	PUNCT
fnp-3806	573	31	.	.	PUNCT
fnp-3806	574	1	autophagy	autophagy	NOUN
fnp-3806	574	2	includes	include	VERB
fnp-3806	574	3	macroautophagy	macroautophagy	ADJ
fnp-3806	574	4	,	,	PUNCT
fnp-3806	574	5	microautophagy	microautophagy	ADJ
fnp-3806	574	6	,	,	PUNCT
fnp-3806	574	7	and	and	CCONJ
fnp-3806	574	8	chaperone	chaperone	NOUN
fnp-3806	574	9	-	-	PUNCT
fnp-3806	574	10	mediated	mediate	VERB
fnp-3806	574	11	autophagy	autophagy	NOUN
fnp-3806	574	12	(	(	PUNCT
fnp-3806	574	13	691	691	NUM
fnp-3806	574	14	)	)	PUNCT
fnp-3806	574	15	.	.	PUNCT
fnp-3806	575	1	microautophagy	microautophagy	PROPN
fnp-3806	575	2	and	and	CCONJ
fnp-3806	575	3	chaperone	chaperone	NOUN
fnp-3806	575	4	-	-	PUNCT
fnp-3806	575	5	mediated	mediate	VERB
fnp-3806	575	6	autophagy	autophagy	NOUN
fnp-3806	575	7	involve	involve	VERB
fnp-3806	575	8	lysosomal	lysosomal	ADJ
fnp-3806	575	9	membrane	membrane	NOUN
fnp-3806	575	10	invagination	invagination	NOUN
fnp-3806	575	11	and	and	CCONJ
fnp-3806	575	12	chaperon	chaperon	NOUN
fnp-3806	575	13	recognition	recognition	NOUN
fnp-3806	575	14	(	(	PUNCT
fnp-3806	575	15	692	692	NUM
fnp-3806	575	16	)	)	PUNCT
fnp-3806	575	17	.	.	PUNCT
fnp-3806	576	1	macroautophagy	macroautophagy	ADJ
fnp-3806	576	2	is	be	AUX
fnp-3806	576	3	mediated	mediate	VERB
fnp-3806	576	4	by	by	ADP
fnp-3806	576	5	autophagosome	autophagosome	VERB
fnp-3806	576	6	protein	protein	NOUN
fnp-3806	576	7	assembly	assembly	NOUN
fnp-3806	576	8	of	of	ADP
fnp-3806	576	9	beclin	beclin	NOUN
fnp-3806	576	10	1	1	NUM
fnp-3806	576	11	-	-	PUNCT
fnp-3806	576	12	vps34	vps34	ADV
fnp-3806	576	13	lipid	lipid	PROPN
fnp-3806	576	14	kinase	kinase	PROPN
fnp-3806	576	15	,	,	PUNCT
fnp-3806	576	16	atg9	atg9	PROPN
fnp-3806	576	17	-	-	PUNCT
fnp-3806	576	18	wipi-1	wipi-1	PROPN
fnp-3806	576	19	,	,	PUNCT
fnp-3806	576	20	atg12	atg12	NOUN
fnp-3806	576	21	conjugation	conjugation	NOUN
fnp-3806	576	22	system	system	NOUN
fnp-3806	576	23	,	,	PUNCT
fnp-3806	576	24	microtubule	microtubule	NOUN
fnp-3806	576	25	-	-	PUNCT
fnp-3806	576	26	associated	associate	VERB
fnp-3806	576	27	protein	protein	NOUN
fnp-3806	576	28	light	light	NOUN
fnp-3806	576	29	chain	chain	NOUN
fnp-3806	576	30	3	3	NUM
fnp-3806	576	31	(	(	PUNCT
fnp-3806	576	32	lc3	lc3	NOUN
fnp-3806	576	33	)	)	PUNCT
fnp-3806	576	34	,	,	PUNCT
fnp-3806	576	35	and	and	CCONJ
fnp-3806	576	36	unc-51	unc-51	ADV
fnp-3806	576	37	-	-	PUNCT
fnp-3806	576	38	like	like	ADJ
fnp-3806	576	39	autophagy	autophagy	NOUN
fnp-3806	576	40	activating	activate	VERB
fnp-3806	576	41	kinase	kinase	PROPN
fnp-3806	576	42	1	1	NUM
fnp-3806	576	43	protein	protein	NOUN
fnp-3806	576	44	kinase	kinase	NOUN
fnp-3806	576	45	.	.	PUNCT
fnp-3806	577	1	lysosomal	lysosomal	NOUN
fnp-3806	577	2	-	-	PUNCT
fnp-3806	577	3	associated	associate	VERB
fnp-3806	577	4	membrane	membrane	NOUN
fnp-3806	577	5	protein	protein	NOUN
fnp-3806	577	6	1	1	NUM
fnp-3806	577	7	(	(	PUNCT
fnp-3806	577	8	lamp-1	lamp-1	NUM
fnp-3806	577	9	)	)	PUNCT
fnp-3806	577	10	is	be	AUX
fnp-3806	577	11	a	a	DET
fnp-3806	577	12	transmembrane	transmembrane	ADJ
fnp-3806	577	13	glycoprotein	glycoprotein	NOUN
fnp-3806	577	14	enriched	enrich	VERB
fnp-3806	577	15	in	in	ADP
fnp-3806	577	16	the	the	DET
fnp-3806	577	17	membrane	membrane	NOUN
fnp-3806	577	18	of	of	ADP
fnp-3806	577	19	lysosomes	lysosome	NOUN
fnp-3806	577	20	(	(	PUNCT
fnp-3806	577	21	693	693	NUM
fnp-3806	577	22	-	-	SYM
fnp-3806	577	23	695	695	NUM
fnp-3806	577	24	)	)	PUNCT
fnp-3806	577	25	.	.	PUNCT
fnp-3806	578	1	material	material	NOUN
fnp-3806	578	2	digested	digest	VERB
fnp-3806	578	3	by	by	ADP
fnp-3806	578	4	autophagy	autophagy	NOUN
fnp-3806	578	5	is	be	AUX
fnp-3806	578	6	incorporated	incorporate	VERB
fnp-3806	578	7	into	into	ADP
fnp-3806	578	8	lysosomes	lysosome	NOUN
fnp-3806	578	9	.	.	PUNCT
fnp-3806	579	1	autophagy	autophagy	NOUN
fnp-3806	579	2	is	be	AUX
fnp-3806	579	3	impaired	impair	VERB
fnp-3806	579	4	in	in	ADP
fnp-3806	579	5	brain	brain	NOUN
fnp-3806	579	6	aging	aging	NOUN
fnp-3806	579	7	and	and	CCONJ
fnp-3806	579	8	sad	sad	ADJ
fnp-3806	579	9	(	(	PUNCT
fnp-3806	579	10	696	696	NUM
fnp-3806	579	11	-	-	SYM
fnp-3806	579	12	706	706	NUM
fnp-3806	579	13	)	)	PUNCT
fnp-3806	579	14	.	.	PUNCT
fnp-3806	580	1	altered	alter	VERB
fnp-3806	580	2	macroautophagy	macroautophagy	NOUN
fnp-3806	580	3	in	in	ADP
fnp-3806	580	4	sad	sad	ADJ
fnp-3806	580	5	is	be	AUX
fnp-3806	580	6	manifested	manifest	VERB
fnp-3806	580	7	in	in	ADP
fnp-3806	580	8	dystrophic	dystrophic	ADJ
fnp-3806	580	9	neurites	neurite	NOUN
fnp-3806	580	10	of	of	ADP
fnp-3806	580	11	sps	sps	PROPN
fnp-3806	580	12	,	,	PUNCT
fnp-3806	580	13	in	in	ADP
fnp-3806	580	14	which	which	PRON
fnp-3806	580	15	mitochondria	mitochondria	NOUN
fnp-3806	580	16	,	,	PUNCT
fnp-3806	580	17	dense	dense	ADJ
fnp-3806	580	18	bodies	body	NOUN
fnp-3806	580	19	,	,	PUNCT
fnp-3806	580	20	and	and	CCONJ
fnp-3806	580	21	vesicles	vesicle	NOUN
fnp-3806	580	22	are	be	AUX
fnp-3806	580	23	common	common	ADJ
fnp-3806	580	24	targets	target	NOUN
fnp-3806	580	25	,	,	PUNCT
fnp-3806	580	26	and	and	CCONJ
fnp-3806	580	27	in	in	ADP
fnp-3806	580	28	synapses	synapsis	NOUN
fnp-3806	580	29	and	and	CCONJ
fnp-3806	580	30	granulovacuolar	granulovacuolar	ADJ
fnp-3806	580	31	degeneration	degeneration	NOUN
fnp-3806	580	32	(	(	PUNCT
fnp-3806	580	33	see	see	VERB
fnp-3806	580	34	section	section	NOUN
fnp-3806	580	35	11	11	NUM
fnp-3806	580	36	)	)	PUNCT
fnp-3806	580	37	.	.	PUNCT
fnp-3806	581	1	autophagy	autophagy	NOUN
fnp-3806	581	2	is	be	AUX
fnp-3806	581	3	also	also	ADV
fnp-3806	581	4	involved	involve	VERB
fnp-3806	581	5	in	in	ADP
fnp-3806	581	6	β	β	NOUN
fnp-3806	581	7	-	-	NOUN
fnp-3806	581	8	amyloid	amyloid	ADJ
fnp-3806	581	9	metabolism	metabolism	NOUN
fnp-3806	581	10	and	and	CCONJ
fnp-3806	581	11	clearance	clearance	NOUN
fnp-3806	581	12	(	(	PUNCT
fnp-3806	581	13	707	707	NUM
fnp-3806	581	14	)	)	PUNCT
fnp-3806	581	15	.	.	PUNCT
fnp-3806	582	1	ups	up	NOUN
fnp-3806	582	2	activity	activity	NOUN
fnp-3806	582	3	is	be	AUX
fnp-3806	582	4	initiated	initiate	VERB
fnp-3806	582	5	by	by	ADP
fnp-3806	582	6	the	the	DET
fnp-3806	582	7	conjugation	conjugation	NOUN
fnp-3806	582	8	of	of	ADP
fnp-3806	582	9	ubiquitin	ubiquitin	NOUN
fnp-3806	582	10	to	to	ADP
fnp-3806	582	11	the	the	DET
fnp-3806	582	12	substrate	substrate	NOUN
fnp-3806	582	13	following	follow	VERB
fnp-3806	582	14	a	a	DET
fnp-3806	582	15	three	three	NUM
fnp-3806	582	16	-	-	PUNCT
fnp-3806	582	17	step	step	NOUN
fnp-3806	582	18	cascade	cascade	NOUN
fnp-3806	582	19	to	to	PART
fnp-3806	582	20	tag	tag	VERB
fnp-3806	582	21	the	the	DET
fnp-3806	582	22	protein	protein	NOUN
fnp-3806	582	23	into	into	ADP
fnp-3806	582	24	the	the	DET
fnp-3806	582	25	proteasome	proteasome	NOUN
fnp-3806	582	26	.	.	PUNCT
fnp-3806	583	1	the	the	DET
fnp-3806	583	2	20s	20	NOUN
fnp-3806	583	3	proteasome	proteasome	NOUN
fnp-3806	583	4	is	be	AUX
fnp-3806	583	5	a	a	DET
fnp-3806	583	6	hetero	hetero	NOUN
fnp-3806	583	7	-	-	PUNCT
fnp-3806	583	8	oligomer	oligomer	NOUN
fnp-3806	583	9	formed	form	VERB
fnp-3806	583	10	by	by	ADP
fnp-3806	583	11	heptameric	heptameric	PROPN
fnp-3806	583	12	rings	ring	NOUN
fnp-3806	583	13	organized	organize	VERB
fnp-3806	583	14	into	into	ADP
fnp-3806	583	15	a	a	DET
fnp-3806	583	16	structure	structure	NOUN
fnp-3806	583	17	resembling	resemble	VERB
fnp-3806	583	18	a	a	DET
fnp-3806	583	19	hollow	hollow	ADJ
fnp-3806	583	20	cylinder	cylinder	NOUN
fnp-3806	583	21	which	which	PRON
fnp-3806	583	22	has	have	VERB
fnp-3806	583	23	three	three	NUM
fnp-3806	583	24	main	main	ADJ
fnp-3806	583	25	peptidase	peptidase	NOUN
fnp-3806	583	26	activities	activity	NOUN
fnp-3806	583	27	:	:	PUNCT
fnp-3806	583	28	chymotrypsin	chymotrypsin	NOUN
fnp-3806	583	29	-	-	PUNCT
fnp-3806	583	30	like	like	ADJ
fnp-3806	583	31	,	,	PUNCT
fnp-3806	583	32	trypsin	trypsin	NOUN
fnp-3806	583	33	-	-	PUNCT
fnp-3806	583	34	like	like	ADJ
fnp-3806	583	35	,	,	PUNCT
fnp-3806	583	36	and	and	CCONJ
fnp-3806	583	37	peptidylglutamyl	peptidylglutamyl	NOUN
fnp-3806	583	38	peptide	peptide	NOUN
fnp-3806	583	39	hydrolyzing	hydrolyzing	NOUN
fnp-3806	583	40	activities	activity	NOUN
fnp-3806	583	41	.	.	PUNCT
fnp-3806	584	1	the	the	DET
fnp-3806	584	2	20s	20s	NUM
fnp-3806	584	3	proteasome	proteasome	NOUN
fnp-3806	584	4	can	can	AUX
fnp-3806	584	5	associate	associate	VERB
fnp-3806	584	6	,	,	PUNCT
fnp-3806	584	7	in	in	ADP
fnp-3806	584	8	the	the	DET
fnp-3806	584	9	presence	presence	NOUN
fnp-3806	584	10	of	of	ADP
fnp-3806	584	11	atp	atp	PROPN
fnp-3806	584	12	,	,	PUNCT
fnp-3806	584	13	with	with	ADP
fnp-3806	584	14	two	two	NUM
fnp-3806	584	15	caps	cap	NOUN
fnp-3806	584	16	or	or	CCONJ
fnp-3806	584	17	19s	19s	NUM
fnp-3806	584	18	complexes	complex	NOUN
fnp-3806	584	19	,	,	PUNCT
fnp-3806	584	20	thereby	thereby	ADV
fnp-3806	584	21	forming	form	VERB
fnp-3806	584	22	the	the	DET
fnp-3806	584	23	26s	26	NOUN
fnp-3806	584	24	proteasome	proteasome	NOUN
fnp-3806	584	25	complex	complex	NOUN
fnp-3806	584	26	.	.	PUNCT
fnp-3806	585	1	the	the	DET
fnp-3806	585	2	19s	19s	NUM
fnp-3806	585	3	complex	complex	NOUN
fnp-3806	585	4	serves	serve	VERB
fnp-3806	585	5	in	in	ADP
fnp-3806	585	6	the	the	DET
fnp-3806	585	7	recognition	recognition	NOUN
fnp-3806	585	8	of	of	ADP
fnp-3806	585	9	ubiquitylated	ubiquitylated	ADJ
fnp-3806	585	10	proteins	protein	NOUN
fnp-3806	585	11	,	,	PUNCT
fnp-3806	585	12	protein	protein	NOUN
fnp-3806	585	13	unfolding	unfolding	NOUN
fnp-3806	585	14	,	,	PUNCT
fnp-3806	585	15	and	and	CCONJ
fnp-3806	585	16	translocation	translocation	NOUN
fnp-3806	585	17	of	of	ADP
fnp-3806	585	18	the	the	DET
fnp-3806	585	19	unfolded	unfold	VERB
fnp-3806	585	20	polypeptide	polypeptide	NOUN
fnp-3806	585	21	to	to	ADP
fnp-3806	585	22	the	the	DET
fnp-3806	585	23	inner	inner	ADJ
fnp-3806	585	24	chambers	chamber	NOUN
fnp-3806	585	25	of	of	ADP
fnp-3806	585	26	the	the	DET
fnp-3806	585	27	20s	20	NOUN
fnp-3806	585	28	proteasome	proteasome	NOUN
fnp-3806	585	29	for	for	ADP
fnp-3806	585	30	hydrolysis	hydrolysis	NOUN
fnp-3806	585	31	.	.	PUNCT
fnp-3806	586	1	the	the	DET
fnp-3806	586	2	20s	20	NOUN
fnp-3806	586	3	proteasome	proteasome	NOUN
fnp-3806	586	4	can	can	AUX
fnp-3806	586	5	interact	interact	VERB
fnp-3806	586	6	with	with	ADP
fnp-3806	586	7	other	other	ADJ
fnp-3806	586	8	complexes	complex	NOUN
fnp-3806	586	9	.	.	PUNCT
fnp-3806	587	1	the	the	DET
fnp-3806	587	2	pa28α	pa28α	NOUN
fnp-3806	587	3	/	/	SYM
fnp-3806	587	4	β	β	NOUN
fnp-3806	587	5	activator	activator	NOUN
fnp-3806	587	6	(	(	PUNCT
fnp-3806	587	7	11s	11	NOUN
fnp-3806	587	8	regulator	regulator	NOUN
fnp-3806	587	9	)	)	PUNCT
fnp-3806	587	10	can	can	AUX
fnp-3806	587	11	also	also	ADV
fnp-3806	587	12	bind	bind	VERB
fnp-3806	587	13	to	to	ADP
fnp-3806	587	14	20s	20	NOUN
fnp-3806	587	15	proteasome	proteasome	NOUN
fnp-3806	587	16	to	to	PART
fnp-3806	587	17	form	form	VERB
fnp-3806	587	18	the	the	DET
fnp-3806	587	19	pa28	pa28	PROPN
fnp-3806	587	20	-	-	PUNCT
fnp-3806	587	21	proteasome	proteasome	NOUN
fnp-3806	587	22	complex	complex	NOUN
fnp-3806	587	23	.	.	PUNCT
fnp-3806	588	1	additionally	additionally	ADV
fnp-3806	588	2	,	,	PUNCT
fnp-3806	588	3	the	the	DET
fnp-3806	588	4	three	three	NUM
fnp-3806	588	5	catalytic	catalytic	ADJ
fnp-3806	588	6	β	β	NOUN
fnp-3806	588	7	subunits	subunit	NOUN
fnp-3806	588	8	of	of	ADP
fnp-3806	588	9	the	the	DET
fnp-3806	588	10	20s	20	NOUN
fnp-3806	588	11	proteasome	proteasome	NOUN
fnp-3806	588	12	in	in	ADP
fnp-3806	588	13	response	response	NOUN
fnp-3806	588	14	to	to	ADP
fnp-3806	588	15	γ	γ	PROPN
fnp-3806	588	16	-	-	ADJ
fnp-3806	588	17	interferon	interferon	NOUN
fnp-3806	588	18	are	be	AUX
fnp-3806	588	19	replaced	replace	VERB
fnp-3806	588	20	by	by	ADP
fnp-3806	588	21	inducible	inducible	ADJ
fnp-3806	588	22	homologous	homologous	ADJ
fnp-3806	588	23	proteins	protein	NOUN
fnp-3806	588	24	lmp2	lmp2	NOUN
fnp-3806	588	25	,	,	PUNCT
fnp-3806	588	26	lmp7	lmp7	PROPN
fnp-3806	588	27	,	,	PUNCT
fnp-3806	588	28	and	and	CCONJ
fnp-3806	588	29	mecl1	mecl1	NOUN
fnp-3806	588	30	,	,	PUNCT
fnp-3806	588	31	forming	form	VERB
fnp-3806	588	32	the	the	DET
fnp-3806	588	33	immunoproteasome	immunoproteasome	NOUN
fnp-3806	588	34	(	(	PUNCT
fnp-3806	588	35	689	689	NUM
fnp-3806	588	36	)	)	PUNCT
fnp-3806	588	37	.	.	PUNCT
fnp-3806	589	1	the	the	DET
fnp-3806	589	2	immunoproteasome	immunoproteasome	NOUN
fnp-3806	589	3	has	have	VERB
fnp-3806	589	4	a	a	DET
fnp-3806	589	5	role	role	NOUN
fnp-3806	589	6	in	in	ADP
fnp-3806	589	7	peptide	peptide	ADJ
fnp-3806	589	8	production	production	NOUN
fnp-3806	589	9	for	for	ADP
fnp-3806	589	10	antigen	antigen	ADJ
fnp-3806	589	11	presentation	presentation	NOUN
fnp-3806	589	12	by	by	ADP
fnp-3806	589	13	the	the	DET
fnp-3806	589	14	major	major	ADJ
fnp-3806	589	15	histocompatibility	histocompatibility	NOUN
fnp-3806	589	16	complex	complex	NOUN
fnp-3806	589	17	in	in	ADP
fnp-3806	589	18	most	most	ADJ
fnp-3806	589	19	settings	setting	NOUN
fnp-3806	589	20	,	,	PUNCT
fnp-3806	589	21	but	but	CCONJ
fnp-3806	589	22	it	it	PRON
fnp-3806	589	23	is	be	AUX
fnp-3806	589	24	also	also	ADV
fnp-3806	589	25	involved	involve	VERB
fnp-3806	589	26	in	in	ADP
fnp-3806	589	27	the	the	DET
fnp-3806	589	28	clearance	clearance	NOUN
fnp-3806	589	29	of	of	ADP
fnp-3806	589	30	oxidatively	oxidatively	ADV
fnp-3806	589	31	damaged	damage	VERB
fnp-3806	589	32	proteins	protein	NOUN
fnp-3806	589	33	(	(	PUNCT
fnp-3806	589	34	708	708	NUM
fnp-3806	589	35	)	)	PUNCT
fnp-3806	589	36	.	.	PUNCT
fnp-3806	590	1	the	the	DET
fnp-3806	590	2	ups	up	NOUN
fnp-3806	590	3	is	be	AUX
fnp-3806	590	4	altered	alter	VERB
fnp-3806	590	5	in	in	ADP
fnp-3806	590	6	brain	brain	NOUN
fnp-3806	590	7	aging	aging	NOUN
fnp-3806	590	8	and	and	CCONJ
fnp-3806	590	9	ad	ad	NOUN
fnp-3806	590	10	(	(	PUNCT
fnp-3806	590	11	709	709	NUM
fnp-3806	590	12	-	-	SYM
fnp-3806	590	13	712	712	NUM
fnp-3806	590	14	)	)	PUNCT
fnp-3806	590	15	.	.	PUNCT
fnp-3806	591	1	impaired	impair	VERB
fnp-3806	591	2	removal	removal	NOUN
fnp-3806	591	3	of	of	ADP
fnp-3806	591	4	altered	altered	ADJ
fnp-3806	591	5	proteins	protein	NOUN
fnp-3806	591	6	is	be	AUX
fnp-3806	591	7	manifested	manifest	VERB
fnp-3806	591	8	by	by	ADP
fnp-3806	591	9	the	the	DET
fnp-3806	591	10	deposition	deposition	NOUN
fnp-3806	591	11	of	of	ADP
fnp-3806	591	12	hyper	hyper	ADV
fnp-3806	591	13	-	-	ADJ
fnp-3806	591	14	phospohorylated	phospohorylate	VERB
fnp-3806	591	15	,	,	PUNCT
fnp-3806	591	16	abnormally	abnormally	ADV
fnp-3806	591	17	conformed	conform	VERB
fnp-3806	591	18	,	,	PUNCT
fnp-3806	591	19	and	and	CCONJ
fnp-3806	591	20	truncated	truncate	VERB
fnp-3806	591	21	ubiquitinated	ubiquitinated	ADJ
fnp-3806	591	22	tau	tau	PROPN
fnp-3806	591	23	species	specie	NOUN
fnp-3806	591	24	resistant	resistant	ADJ
fnp-3806	591	25	to	to	ADP
fnp-3806	591	26	ups	up	NOUN
fnp-3806	591	27	degradation	degradation	NOUN
fnp-3806	591	28	in	in	ADP
fnp-3806	591	29	nfts	nft	NOUN
fnp-3806	591	30	,	,	PUNCT
fnp-3806	591	31	dystrophic	dystrophic	ADJ
fnp-3806	591	32	neurites	neurite	NOUN
fnp-3806	591	33	,	,	PUNCT
fnp-3806	591	34	and	and	CCONJ
fnp-3806	591	35	threads	thread	NOUN
fnp-3806	591	36	(	(	PUNCT
fnp-3806	591	37	197	197	NUM
fnp-3806	591	38	)	)	PUNCT
fnp-3806	591	39	.	.	PUNCT
fnp-3806	592	1	in	in	ADP
fnp-3806	592	2	addition	addition	NOUN
fnp-3806	592	3	to	to	ADP
fnp-3806	592	4	ubiquitin	ubiquitin	ADJ
fnp-3806	592	5	,	,	PUNCT
fnp-3806	592	6	mutant	mutant	ADJ
fnp-3806	592	7	ubiquitin	ubiquitin	NOUN
fnp-3806	592	8	is	be	AUX
fnp-3806	592	9	expressed	express	VERB
fnp-3806	592	10	in	in	ADP
fnp-3806	592	11	the	the	DET
fnp-3806	592	12	aging	age	VERB
fnp-3806	592	13	brain	brain	NOUN
fnp-3806	592	14	and	and	CCONJ
fnp-3806	592	15	at	at	ADP
fnp-3806	592	16	early	early	ADJ
fnp-3806	592	17	stages	stage	NOUN
fnp-3806	592	18	of	of	ADP
fnp-3806	592	19	sad	sad	ADJ
fnp-3806	592	20	,	,	PUNCT
fnp-3806	592	21	whereas	whereas	SCONJ
fnp-3806	592	22	misframed	misframe	VERB
fnp-3806	592	23	ubiquitin	ubiquitin	NOUN
fnp-3806	592	24	contributes	contribute	VERB
fnp-3806	592	25	to	to	ADP
fnp-3806	592	26	the	the	DET
fnp-3806	592	27	blockade	blockade	NOUN
fnp-3806	592	28	of	of	ADP
fnp-3806	592	29	the	the	DET
fnp-3806	592	30	proteasome	proteasome	NOUN
fnp-3806	592	31	by	by	ADP
fnp-3806	592	32	nfts	nft	NOUN
fnp-3806	592	33	and	and	CCONJ
fnp-3806	592	34	other	other	ADJ
fnp-3806	592	35	tau	tau	PROPN
fnp-3806	592	36	inclusions	inclusion	NOUN
fnp-3806	592	37	(	(	PUNCT
fnp-3806	592	38	229	229	NUM
fnp-3806	592	39	,	,	PUNCT
fnp-3806	592	40	230	230	NUM
fnp-3806	592	41	,	,	PUNCT
fnp-3806	592	42	713	713	NUM
fnp-3806	592	43	-	-	PUNCT
fnp-3806	592	44	716	716	NUM
fnp-3806	592	45	)	)	PUNCT
fnp-3806	592	46	.	.	PUNCT
fnp-3806	593	1	yet	yet	ADV
fnp-3806	593	2	,	,	PUNCT
fnp-3806	593	3	mutant	mutant	ADJ
fnp-3806	593	4	ubiquitin	ubiquitin	NOUN
fnp-3806	593	5	reduces	reduce	VERB
fnp-3806	593	6	aβ	aβ	DET
fnp-3806	593	7	plaque	plaque	NOUN
fnp-3806	593	8	formation	formation	NOUN
fnp-3806	593	9	(	(	PUNCT
fnp-3806	593	10	717	717	NUM
fnp-3806	593	11	,	,	PUNCT
fnp-3806	593	12	718	718	NUM
fnp-3806	593	13	)	)	PUNCT
fnp-3806	593	14	.	.	PUNCT
fnp-3806	594	1	the	the	DET
fnp-3806	594	2	immunoproteasome	immunoproteasome	NOUN
fnp-3806	594	3	is	be	AUX
fnp-3806	594	4	activated	activate	VERB
fnp-3806	594	5	in	in	ADP
fnp-3806	594	6	ad	ad	NOUN
fnp-3806	594	7	and	and	CCONJ
fnp-3806	594	8	app	app	PROPN
fnp-3806	594	9	/	/	SYM
fnp-3806	594	10	ps1	ps1	NOUN
fnp-3806	594	11	double	double	ADJ
fnp-3806	594	12	-	-	PUNCT
fnp-3806	594	13	transgenic	transgenic	NOUN
fnp-3806	594	14	mice	mouse	NOUN
fnp-3806	594	15	(	(	PUNCT
fnp-3806	594	16	719	719	NUM
fnp-3806	594	17	-	-	SYM
fnp-3806	594	18	721	721	NUM
fnp-3806	594	19	)	)	PUNCT
fnp-3806	594	20	.	.	PUNCT
fnp-3806	595	1	the	the	DET
fnp-3806	595	2	reasons	reason	NOUN
fnp-3806	595	3	for	for	ADP
fnp-3806	595	4	immunoproteasome	immunoproteasome	NOUN
fnp-3806	595	5	activation	activation	NOUN
fnp-3806	595	6	are	be	AUX
fnp-3806	595	7	not	not	PART
fnp-3806	595	8	fully	fully	ADV
fnp-3806	595	9	understood	understand	VERB
fnp-3806	595	10	,	,	PUNCT
fnp-3806	595	11	but	but	CCONJ
fnp-3806	595	12	the	the	DET
fnp-3806	595	13	presence	presence	NOUN
fnp-3806	595	14	of	of	ADP
fnp-3806	595	15	advanced	advanced	ADJ
fnp-3806	595	16	glycation	glycation	NOUN
fnp-3806	595	17	end	end	NOUN
fnp-3806	595	18	products	product	NOUN
fnp-3806	595	19	(	(	PUNCT
fnp-3806	595	20	ages	age	NOUN
fnp-3806	595	21	)	)	PUNCT
fnp-3806	595	22	appears	appear	VERB
fnp-3806	595	23	to	to	PART
fnp-3806	595	24	induce	induce	VERB
fnp-3806	595	25	activation	activation	NOUN
fnp-3806	595	26	of	of	ADP
fnp-3806	595	27	the	the	DET
fnp-3806	595	28	immunoproteasome	immunoproteasome	NOUN
fnp-3806	595	29	;	;	PUNCT
fnp-3806	595	30	the	the	DET
fnp-3806	595	31	inhibition	inhibition	NOUN
fnp-3806	595	32	of	of	ADP
fnp-3806	595	33	age	age	NOUN
fnp-3806	595	34	receptor	receptor	NOUN
fnp-3806	595	35	(	(	PUNCT
fnp-3806	595	36	rage	rage	NOUN
fnp-3806	595	37	)	)	PUNCT
fnp-3806	595	38	,	,	PUNCT
fnp-3806	595	39	and	and	CCONJ
fnp-3806	595	40	the	the	DET
fnp-3806	595	41	downstream	downstream	ADJ
fnp-3806	595	42	signalling	signal	VERB
fnp-3806	595	43	jak2	jak2	NOUN
fnp-3806	595	44	(	(	PUNCT
fnp-3806	595	45	janus	janus	PROPN
fnp-3806	595	46	kinase	kinase	PROPN
fnp-3806	595	47	2)/stat1	2)/stat1	NUM
fnp-3806	595	48	(	(	PUNCT
fnp-3806	595	49	signal	signal	NOUN
fnp-3806	595	50	transducer	transducer	NOUN
fnp-3806	595	51	and	and	CCONJ
fnp-3806	595	52	activator	activator	NOUN
fnp-3806	595	53	of	of	ADP
fnp-3806	595	54	transcription	transcription	NOUN
fnp-3806	595	55	1	1	NUM
fnp-3806	595	56	)	)	PUNCT
fnp-3806	595	57	abolishes	abolish	VERB
fnp-3806	595	58	age	age	NOUN
fnp-3806	595	59	-	-	PUNCT
fnp-3806	595	60	induced	induce	VERB
fnp-3806	595	61	activation	activation	NOUN
fnp-3806	595	62	of	of	ADP
fnp-3806	595	63	the	the	DET
fnp-3806	595	64	immunoproteasome	immunoproteasome	NOUN
fnp-3806	595	65	(	(	PUNCT
fnp-3806	595	66	722	722	NUM
fnp-3806	595	67	)	)	PUNCT
fnp-3806	595	68	.	.	PUNCT
fnp-3806	596	1	11	11	NUM
fnp-3806	596	2	.	.	X
fnp-3806	596	3	granulovacuolar	granulovacuolar	ADJ
fnp-3806	596	4	degeneration	degeneration	NOUN
fnp-3806	596	5	(	(	PUNCT
fnp-3806	596	6	gvd	gvd	PROPN
fnp-3806	596	7	)	)	PUNCT
fnp-3806	596	8	gvd	gvd	PROPN
fnp-3806	596	9	is	be	AUX
fnp-3806	596	10	characterized	characterize	VERB
fnp-3806	596	11	by	by	ADP
fnp-3806	596	12	the	the	DET
fnp-3806	596	13	presence	presence	NOUN
fnp-3806	596	14	of	of	ADP
fnp-3806	596	15	vacuolar	vacuolar	ADJ
fnp-3806	596	16	cytoplasmic	cytoplasmic	ADJ
fnp-3806	596	17	lesions	lesion	NOUN
fnp-3806	596	18	with	with	ADP
fnp-3806	596	19	a	a	DET
fnp-3806	596	20	dense	dense	ADJ
fnp-3806	596	21	central	central	ADJ
fnp-3806	596	22	core	core	NOUN
fnp-3806	596	23	,	,	PUNCT
fnp-3806	596	24	mainly	mainly	ADV
fnp-3806	596	25	in	in	ADP
fnp-3806	596	26	ca1	ca1	PROPN
fnp-3806	596	27	hippocampal	hippocampal	ADJ
fnp-3806	596	28	neurons	neuron	NOUN
fnp-3806	596	29	(	(	PUNCT
fnp-3806	596	30	18	18	NUM
fnp-3806	596	31	)	)	PUNCT
fnp-3806	596	32	.	.	PUNCT
fnp-3806	597	1	gvd	gvd	PROPN
fnp-3806	597	2	is	be	AUX
fnp-3806	597	3	common	common	ADJ
fnp-3806	597	4	in	in	ADP
fnp-3806	597	5	the	the	DET
fnp-3806	597	6	hippocampus	hippocampus	NOUN
fnp-3806	597	7	in	in	ADP
fnp-3806	597	8	the	the	DET
fnp-3806	597	9	aging	age	VERB
fnp-3806	597	10	human	human	ADJ
fnp-3806	597	11	brain	brain	NOUN
fnp-3806	597	12	and	and	CCONJ
fnp-3806	597	13	present	present	ADJ
fnp-3806	597	14	in	in	ADP
fnp-3806	597	15	the	the	DET
fnp-3806	597	16	majority	majority	NOUN
fnp-3806	597	17	,	,	PUNCT
fnp-3806	597	18	if	if	SCONJ
fnp-3806	597	19	not	not	PART
fnp-3806	597	20	all	all	DET
fnp-3806	597	21	cases	case	NOUN
fnp-3806	597	22	,	,	PUNCT
fnp-3806	597	23	of	of	ADP
fnp-3806	597	24	sad	sad	ADJ
fnp-3806	597	25	(	(	PUNCT
fnp-3806	597	26	figure	figure	NOUN
fnp-3806	597	27	8)	8)	NUM
fnp-3806	597	28	.	.	PUNCT
fnp-3806	598	1	gvd	gvd	PROPN
fnp-3806	598	2	first	first	ADV
fnp-3806	598	3	appears	appear	VERB
fnp-3806	598	4	in	in	ADP
fnp-3806	598	5	neurons	neuron	NOUN
fnp-3806	598	6	of	of	ADP
fnp-3806	598	7	the	the	DET
fnp-3806	598	8	hippocampal	hippocampal	ADJ
fnp-3806	598	9	subfields	subfield	NOUN
fnp-3806	598	10	ca1	ca1	PROPN
fnp-3806	598	11	and	and	CCONJ
fnp-3806	598	12	ca2	ca2	PROPN
fnp-3806	598	13	,	,	PUNCT
fnp-3806	598	14	and	and	CCONJ
fnp-3806	598	15	the	the	DET
fnp-3806	598	16	subiculum	subiculum	NOUN
fnp-3806	598	17	;	;	PUNCT
fnp-3806	598	18	this	this	PRON
fnp-3806	598	19	is	be	AUX
fnp-3806	598	20	followed	follow	VERB
fnp-3806	598	21	by	by	ADP
fnp-3806	598	22	the	the	DET
fnp-3806	598	23	entorhinal	entorhinal	ADJ
fnp-3806	598	24	cortex	cortex	NOUN
fnp-3806	598	25	,	,	PUNCT
fnp-3806	598	26	and	and	CCONJ
fnp-3806	598	27	ca4	ca4	NOUN
fnp-3806	598	28	neurons	neuron	NOUN
fnp-3806	598	29	in	in	ADP
fnp-3806	598	30	stage	stage	NOUN
fnp-3806	598	31	2	2	NUM
fnp-3806	598	32	,	,	PUNCT
fnp-3806	598	33	temporal	temporal	ADJ
fnp-3806	598	34	neocortex	neocortex	NOUN
fnp-3806	598	35	in	in	ADP
fnp-3806	598	36	stage	stage	NOUN
fnp-3806	598	37	3	3	NUM
fnp-3806	598	38	,	,	PUNCT
fnp-3806	598	39	amygdala	amygdala	NOUN
fnp-3806	598	40	and/or	and/or	CCONJ
fnp-3806	598	41	the	the	DET
fnp-3806	598	42	hypothalamus	hypothalamus	NOUN
fnp-3806	598	43	in	in	ADP
fnp-3806	598	44	stage	stage	NOUN
fnp-3806	598	45	4	4	NUM
fnp-3806	598	46	,	,	PUNCT
fnp-3806	598	47	and	and	CCONJ
fnp-3806	598	48	cingulate	cingulate	VERB
fnp-3806	598	49	,	,	PUNCT
fnp-3806	598	50	frontal	frontal	ADJ
fnp-3806	598	51	,	,	PUNCT
fnp-3806	598	52	and	and	CCONJ
fnp-3806	598	53	parietal	parietal	ADJ
fnp-3806	598	54	cortices	cortex	NOUN
fnp-3806	598	55	in	in	ADP
fnp-3806	598	56	stage	stage	NOUN
fnp-3806	598	57	5	5	NUM
fnp-3806	598	58	(	(	PUNCT
fnp-3806	598	59	723	723	NUM
fnp-3806	598	60	)	)	PUNCT
fnp-3806	598	61	.	.	PUNCT
fnp-3806	599	1	gvd	gvd	PROPN
fnp-3806	599	2	appears	appear	VERB
fnp-3806	599	3	in	in	ADP
fnp-3806	599	4	relation	relation	NOUN
fnp-3806	599	5	to	to	PART
fnp-3806	599	6	hippocampal	hippocampal	VERB
fnp-3806	599	7	phosphorylated	phosphorylate	VERB
fnp-3806	599	8	tau	tau	PROPN
fnp-3806	599	9	accumulation	accumulation	NOUN
fnp-3806	599	10	in	in	ADP
fnp-3806	599	11	various	various	ADJ
fnp-3806	599	12	neurodegenerative	neurodegenerative	ADJ
fnp-3806	599	13	disorders	disorder	NOUN
fnp-3806	599	14	,	,	PUNCT
fnp-3806	599	15	particularly	particularly	ADV
fnp-3806	599	16	ad	ad	NOUN
fnp-3806	599	17	(	(	PUNCT
fnp-3806	599	18	724	724	NUM
fnp-3806	599	19	)	)	PUNCT
fnp-3806	599	20	.	.	PUNCT
fnp-3806	600	1	the	the	DET
fnp-3806	600	2	most	most	ADV
fnp-3806	600	3	widely	widely	ADV
fnp-3806	600	4	accepted	accept	VERB
fnp-3806	600	5	model	model	NOUN
fnp-3806	600	6	of	of	ADP
fnp-3806	600	7	agd	agd	PROPN
fnp-3806	600	8	generation	generation	NOUN
fnp-3806	600	9	follows	follow	VERB
fnp-3806	600	10	the	the	DET
fnp-3806	600	11	scheme	scheme	NOUN
fnp-3806	600	12	:	:	PUNCT
fnp-3806	600	13	abnormal	abnormal	ADJ
fnp-3806	600	14	tau	tau	PROPN
fnp-3806	600	15	in	in	ADP
fnp-3806	600	16	pretangles	pretangle	NOUN
fnp-3806	600	17	induces	induce	VERB
fnp-3806	600	18	abnormal	abnormal	ADJ
fnp-3806	600	19	reticulum	reticulum	NOUN
fnp-3806	600	20	stress	stress	NOUN
fnp-3806	600	21	responses	response	NOUN
fnp-3806	600	22	,	,	PUNCT
fnp-3806	600	23	which	which	PRON
fnp-3806	600	24	in	in	ADP
fnp-3806	600	25	turn	turn	NOUN
fnp-3806	600	26	trigger	trigger	NOUN
fnp-3806	600	27	endocytic	endocytic	ADJ
fnp-3806	600	28	and	and	CCONJ
fnp-3806	600	29	autophagic	autophagic	ADJ
fnp-3806	600	30	pathways	pathway	NOUN
fnp-3806	600	31	in	in	ADP
fnp-3806	600	32	the	the	DET
fnp-3806	600	33	face	face	NOUN
fnp-3806	600	34	of	of	ADP
fnp-3806	600	35	impaired	impaired	ADJ
fnp-3806	600	36	proteolysis	proteolysis	NOUN
fnp-3806	600	37	and	and	CCONJ
fnp-3806	600	38	altered	alter	VERB
fnp-3806	600	39	function	function	NOUN
fnp-3806	600	40	of	of	ADP
fnp-3806	600	41	the	the	DET
fnp-3806	600	42	ups	up	NOUN
fnp-3806	600	43	.	.	PUNCT
fnp-3806	601	1	this	this	DET
fnp-3806	601	2	scenario	scenario	NOUN
fnp-3806	601	3	is	be	AUX
fnp-3806	601	4	consistent	consistent	ADJ
fnp-3806	601	5	with	with	ADP
fnp-3806	601	6	the	the	DET
fnp-3806	601	7	idea	idea	NOUN
fnp-3806	601	8	that	that	PRON
fnp-3806	601	9	gvd	gvd	PROPN
fnp-3806	601	10	is	be	AUX
fnp-3806	601	11	the	the	DET
fnp-3806	601	12	final	final	ADJ
fnp-3806	601	13	stage	stage	NOUN
fnp-3806	601	14	of	of	ADP
fnp-3806	601	15	an	an	DET
fnp-3806	601	16	active	active	ADJ
fnp-3806	601	17	process	process	NOUN
fnp-3806	601	18	linked	link	VERB
fnp-3806	601	19	to	to	ADP
fnp-3806	601	20	failed	fail	VERB
fnp-3806	601	21	degradation	degradation	NOUN
fnp-3806	601	22	of	of	ADP
fnp-3806	601	23	abnormal	abnormal	ADJ
fnp-3806	601	24	protein	protein	NOUN
fnp-3806	601	25	aggregates	aggregate	NOUN
fnp-3806	601	26	in	in	ADP
fnp-3806	601	27	the	the	DET
fnp-3806	601	28	cytoplasm	cytoplasm	NOUN
fnp-3806	601	29	of	of	ADP
fnp-3806	601	30	a	a	DET
fnp-3806	601	31	subpopulation	subpopulation	NOUN
fnp-3806	601	32	of	of	ADP
fnp-3806	601	33	neurons	neuron	NOUN
fnp-3806	601	34	(	(	PUNCT
fnp-3806	601	35	677	677	NUM
fnp-3806	601	36	,	,	PUNCT
fnp-3806	601	37	725	725	NUM
fnp-3806	601	38	-	-	SYM
fnp-3806	601	39	727	727	NUM
fnp-3806	601	40	)	)	PUNCT
fnp-3806	601	41	.	.	PUNCT
fnp-3806	602	1	immunohistochemistry	immunohistochemistry	PROPN
fnp-3806	602	2	to	to	ADP
fnp-3806	602	3	casein	casein	PROPN
fnp-3806	602	4	kinase	kinase	PROPN
fnp-3806	602	5	1δ	1δ	PROPN
fnp-3806	602	6	(	(	PUNCT
fnp-3806	602	7	ck1	ck1	PROPN
fnp-3806	602	8	-	-	PUNCT
fnp-3806	602	9	δ	δ	PROPN
fnp-3806	602	10	)	)	PUNCT
fnp-3806	602	11	and	and	CCONJ
fnp-3806	602	12	at8	at8	PROPN
fnp-3806	602	13	and	and	CCONJ
fnp-3806	602	14	laser	laser	NOUN
fnp-3806	602	15	microdissection	microdissection	NOUN
fnp-3806	602	16	have	have	AUX
fnp-3806	602	17	identified	identify	VERB
fnp-3806	602	18	the	the	DET
fnp-3806	602	19	proteomes	proteome	NOUN
fnp-3806	602	20	of	of	ADP
fnp-3806	602	21	neurons	neuron	NOUN
fnp-3806	602	22	containing	contain	VERB
fnp-3806	602	23	gvd	gvd	NOUN
fnp-3806	602	24	and	and	CCONJ
fnp-3806	602	25	nfts	nft	NOUN
fnp-3806	602	26	,	,	PUNCT
fnp-3806	602	27	respectively	respectively	ADV
fnp-3806	602	28	,	,	PUNCT
fnp-3806	602	29	using	use	VERB
fnp-3806	602	30	label	label	NOUN
fnp-3806	602	31	-	-	PUNCT
fnp-3806	602	32	free	free	ADJ
fnp-3806	602	33	lc	lc	PROPN
fnp-3806	602	34	-	-	PUNCT
fnp-3806	602	35	ms	ms	PROPN
fnp-3806	602	36	/	/	SYM
fnp-3806	602	37	ms	ms	PROPN
fnp-3806	602	38	(	(	PUNCT
fnp-3806	602	39	728	728	NUM
fnp-3806	602	40	)	)	PUNCT
fnp-3806	602	41	.	.	PUNCT
fnp-3806	603	1	a	a	DET
fnp-3806	603	2	significant	significant	ADJ
fnp-3806	603	3	change	change	NOUN
fnp-3806	603	4	in	in	ADP
fnp-3806	603	5	the	the	DET
fnp-3806	603	6	abundance	abundance	NOUN
fnp-3806	603	7	of	of	ADP
fnp-3806	603	8	115	115	NUM
fnp-3806	603	9	proteins	protein	NOUN
fnp-3806	603	10	in	in	ADP
fnp-3806	603	11	gvd	gvd	NOUN
fnp-3806	603	12	-	-	PUNCT
fnp-3806	603	13	containing	contain	VERB
fnp-3806	603	14	neurons	neuron	NOUN
fnp-3806	603	15	and	and	CCONJ
fnp-3806	603	16	197	197	NUM
fnp-3806	603	17	in	in	ADP
fnp-3806	603	18	nft	nft	PROPN
fnp-3806	603	19	-	-	PUNCT
fnp-3806	603	20	containing	contain	VERB
fnp-3806	603	21	neurons	neuron	NOUN
fnp-3806	603	22	was	be	AUX
fnp-3806	603	23	observed	observe	VERB
fnp-3806	603	24	compared	compare	VERB
fnp-3806	603	25	to	to	ADP
fnp-3806	603	26	control	control	VERB
fnp-3806	603	27	neurons	neuron	NOUN
fnp-3806	603	28	(	(	PUNCT
fnp-3806	603	29	728	728	NUM
fnp-3806	603	30	)	)	PUNCT
fnp-3806	603	31	.	.	PUNCT
fnp-3806	604	1	differences	difference	NOUN
fnp-3806	604	2	in	in	ADP
fnp-3806	604	3	protein	protein	NOUN
fnp-3806	604	4	composition	composition	NOUN
fnp-3806	604	5	between	between	ADP
fnp-3806	604	6	nfts	nft	NOUN
fnp-3806	604	7	and	and	CCONJ
fnp-3806	604	8	neurons	neuron	NOUN
fnp-3806	604	9	with	with	ADP
fnp-3806	604	10	gvd	gvd	NOUN
fnp-3806	604	11	are	be	AUX
fnp-3806	604	12	further	far	ADV
fnp-3806	604	13	supported	support	VERB
fnp-3806	604	14	by	by	ADP
fnp-3806	604	15	the	the	DET
fnp-3806	604	16	demonstration	demonstration	NOUN
fnp-3806	604	17	of	of	ADP
fnp-3806	604	18	different	different	ADJ
fnp-3806	604	19	activation	activation	NOUN
fnp-3806	604	20	of	of	ADP
fnp-3806	604	21	kinases	kinase	NOUN
fnp-3806	604	22	and	and	CCONJ
fnp-3806	604	23	different	different	ADJ
fnp-3806	604	24	profiles	profile	NOUN
fnp-3806	604	25	of	of	ADP
fnp-3806	604	26	phosphorylated	phosphorylate	VERB
fnp-3806	604	27	proteins	protein	NOUN
fnp-3806	604	28	(	(	PUNCT
fnp-3806	604	29	139	139	NUM
fnp-3806	604	30	)	)	PUNCT
fnp-3806	604	31	.	.	PUNCT
fnp-3806	605	1	nonetheless	nonetheless	ADV
fnp-3806	605	2	,	,	PUNCT
fnp-3806	605	3	the	the	DET
fnp-3806	605	4	same	same	ADJ
fnp-3806	605	5	study	study	NOUN
fnp-3806	605	6	of	of	ADP
fnp-3806	605	7	phosphoprotein	phosphoprotein	ADJ
fnp-3806	605	8	expression	expression	NOUN
fnp-3806	605	9	showed	show	VERB
fnp-3806	605	10	that	that	SCONJ
fnp-3806	605	11	abnormal	abnormal	ADJ
fnp-3806	605	12	phosphorylation	phosphorylation	NOUN
fnp-3806	605	13	of	of	ADP
fnp-3806	605	14	various	various	ADJ
fnp-3806	605	15	substrates	substrate	NOUN
fnp-3806	605	16	is	be	AUX
fnp-3806	605	17	common	common	ADJ
fnp-3806	605	18	at	at	ADP
fnp-3806	605	19	the	the	DET
fnp-3806	605	20	first	first	ADJ
fnp-3806	605	21	stages	stage	NOUN
fnp-3806	605	22	of	of	ADP
fnp-3806	605	23	nft	nft	PROPN
fnp-3806	605	24	and	and	CCONJ
fnp-3806	605	25	gvd	gvd	PROPN
fnp-3806	605	26	generation	generation	NOUN
fnp-3806	605	27	(	(	PUNCT
fnp-3806	605	28	139	139	NUM
fnp-3806	605	29	)	)	PUNCT
fnp-3806	605	30	.	.	PUNCT
fnp-3806	606	1	these	these	DET
fnp-3806	606	2	observations	observation	NOUN
fnp-3806	606	3	suggest	suggest	VERB
fnp-3806	606	4	that	that	SCONJ
fnp-3806	606	5	gvd	gvd	NOUN
fnp-3806	606	6	is	be	AUX
fnp-3806	606	7	not	not	PART
fnp-3806	606	8	restricted	restrict	VERB
fnp-3806	606	9	to	to	ADP
fnp-3806	606	10	tau	tau	PROPN
fnp-3806	606	11	pathology	pathology	NOUN
fnp-3806	606	12	but	but	CCONJ
fnp-3806	606	13	rather	rather	ADV
fnp-3806	606	14	involves	involve	VERB
fnp-3806	606	15	a	a	DET
fnp-3806	606	16	varied	varied	ADJ
fnp-3806	606	17	number	number	NOUN
fnp-3806	606	18	of	of	ADP
fnp-3806	606	19	proteins	protein	NOUN
fnp-3806	606	20	.	.	PUNCT
fnp-3806	607	1	since	since	SCONJ
fnp-3806	607	2	gvd	gvd	PROPN
fnp-3806	607	3	is	be	AUX
fnp-3806	607	4	common	common	ADJ
fnp-3806	607	5	in	in	ADP
fnp-3806	607	6	the	the	DET
fnp-3806	607	7	older	old	ADJ
fnp-3806	607	8	human	human	ADJ
fnp-3806	607	9	population	population	NOUN
fnp-3806	607	10	,	,	PUNCT
fnp-3806	607	11	it	it	PRON
fnp-3806	607	12	is	be	AUX
fnp-3806	607	13	not	not	PART
fnp-3806	607	14	surprising	surprising	ADJ
fnp-3806	607	15	to	to	PART
fnp-3806	607	16	find	find	VERB
fnp-3806	607	17	a	a	DET
fnp-3806	607	18	correlation	correlation	NOUN
fnp-3806	607	19	between	between	ADP
fnp-3806	607	20	gvd	gvd	NOUN
fnp-3806	607	21	pathology	pathology	NOUN
fnp-3806	607	22	and	and	CCONJ
fnp-3806	607	23	cognitive	cognitive	ADJ
fnp-3806	607	24	impairment	impairment	NOUN
fnp-3806	607	25	.	.	PUNCT
fnp-3806	608	1	however	however	ADV
fnp-3806	608	2	,	,	PUNCT
fnp-3806	608	3	when	when	SCONJ
fnp-3806	608	4	analysis	analysis	NOUN
fnp-3806	608	5	is	be	AUX
fnp-3806	608	6	controlled	control	VERB
fnp-3806	608	7	for	for	ADP
fnp-3806	608	8	other	other	ADJ
fnp-3806	608	9	associated	associated	ADJ
fnp-3806	608	10	neuropathologies	neuropathologie	NOUN
fnp-3806	608	11	,	,	PUNCT
fnp-3806	608	12	the	the	DET
fnp-3806	608	13	associations	association	NOUN
fnp-3806	608	14	between	between	ADP
fnp-3806	608	15	gvd	gvd	PROPN
fnp-3806	608	16	and	and	CCONJ
fnp-3806	608	17	dementia	dementia	NOUN
fnp-3806	608	18	lose	lose	VERB
fnp-3806	608	19	significance	significance	NOUN
fnp-3806	608	20	(	(	PUNCT
fnp-3806	608	21	729	729	NUM
fnp-3806	608	22	)	)	PUNCT
fnp-3806	608	23	.	.	PUNCT
fnp-3806	609	1	figure	figure	VERB
fnp-3806	609	2	8	8	NUM
fnp-3806	609	3	:	:	PUNCT
fnp-3806	609	4	granulovacuolar	granulovacuolar	ADJ
fnp-3806	609	5	degeneration	degeneration	NOUN
fnp-3806	609	6	(	(	PUNCT
fnp-3806	609	7	black	black	ADJ
fnp-3806	609	8	arrows	arrow	NOUN
fnp-3806	609	9	)	)	PUNCT
fnp-3806	609	10	in	in	ADP
fnp-3806	609	11	neurons	neuron	NOUN
fnp-3806	609	12	of	of	ADP
fnp-3806	609	13	the	the	DET
fnp-3806	609	14	hippocampus	hippocampus	NOUN
fnp-3806	609	15	.	.	PUNCT
fnp-3806	610	1	paraffin	paraffin	NOUN
fnp-3806	610	2	section	section	NOUN
fnp-3806	610	3	,	,	PUNCT
fnp-3806	610	4	p38	p38	NOUN
fnp-3806	610	5	-	-	PUNCT
fnp-3806	610	6	p	p	NOUN
fnp-3806	610	7	immunohistochemistry	immunohistochemistry	NOUN
fnp-3806	610	8	,	,	PUNCT
fnp-3806	610	9	slight	slight	ADJ
fnp-3806	610	10	haematoxylin	haematoxylin	NOUN
fnp-3806	610	11	counterstaining	counterstaining	NOUN
fnp-3806	610	12	,	,	PUNCT
fnp-3806	610	13	bar	bar	NOUN
fnp-3806	610	14	=	=	PUNCT
fnp-3806	610	15	25	25	NUM
fnp-3806	610	16	μm	μm	NOUN
fnp-3806	610	17	.	.	PUNCT
fnp-3806	610	18	12	12	NUM
fnp-3806	610	19	.	.	PUNCT
fnp-3806	611	1	glial	glial	ADJ
fnp-3806	611	2	alterations	alteration	NOUN
fnp-3806	611	3	in	in	ADP
fnp-3806	611	4	aging	age	VERB
fnp-3806	611	5	and	and	CCONJ
fnp-3806	611	6	sad	sad	ADJ
fnp-3806	611	7	glial	glial	ADJ
fnp-3806	611	8	cells	cell	NOUN
fnp-3806	611	9	are	be	AUX
fnp-3806	611	10	altered	alter	VERB
fnp-3806	611	11	in	in	ADP
fnp-3806	611	12	aging	aging	NOUN
fnp-3806	611	13	and	and	CCONJ
fnp-3806	611	14	sad	sad	ADJ
fnp-3806	611	15	.	.	PUNCT
fnp-3806	612	1	changes	change	NOUN
fnp-3806	612	2	in	in	ADP
fnp-3806	612	3	glial	glial	ADJ
fnp-3806	612	4	cells	cell	NOUN
fnp-3806	612	5	have	have	VERB
fnp-3806	612	6	multiple	multiple	ADJ
fnp-3806	612	7	facets	facet	NOUN
fnp-3806	612	8	,	,	PUNCT
fnp-3806	612	9	including	include	VERB
fnp-3806	612	10	cell	cell	NOUN
fnp-3806	612	11	senescence	senescence	NOUN
fnp-3806	612	12	,	,	PUNCT
fnp-3806	612	13	astrocytic	astrocytic	ADJ
fnp-3806	612	14	gliosis	gliosis	NOUN
fnp-3806	612	15	,	,	PUNCT
fnp-3806	612	16	microgliosis	microgliosis	NOUN
fnp-3806	612	17	,	,	PUNCT
fnp-3806	612	18	activated	activate	VERB
fnp-3806	612	19	inflammatory	inflammatory	ADJ
fnp-3806	612	20	responses	response	NOUN
fnp-3806	612	21	,	,	PUNCT
fnp-3806	612	22	and	and	CCONJ
fnp-3806	612	23	calcium	calcium	NOUN
fnp-3806	612	24	homeostasis	homeostasis	NOUN
fnp-3806	612	25	,	,	PUNCT
fnp-3806	612	26	among	among	ADP
fnp-3806	612	27	others	other	NOUN
fnp-3806	612	28	.	.	PUNCT
fnp-3806	613	1	astrocytes	astrocyte	NOUN
fnp-3806	613	2	are	be	AUX
fnp-3806	613	3	key	key	ADJ
fnp-3806	613	4	players	player	NOUN
fnp-3806	613	5	in	in	ADP
fnp-3806	613	6	ad	ad	NOUN
fnp-3806	613	7	modulating	modulate	VERB
fnp-3806	613	8	β	β	NOUN
fnp-3806	613	9	-	-	ADJ
fnp-3806	613	10	amyloid	amyloid	ADJ
fnp-3806	613	11	turnover	turnover	NOUN
fnp-3806	613	12	,	,	PUNCT
fnp-3806	613	13	calcium	calcium	NOUN
fnp-3806	613	14	homeosthasis	homeosthasis	NOUN
fnp-3806	613	15	,	,	PUNCT
fnp-3806	613	16	tripartite	tripartite	ADJ
fnp-3806	613	17	synaptic	synaptic	ADJ
fnp-3806	613	18	function	function	NOUN
fnp-3806	613	19	,	,	PUNCT
fnp-3806	613	20	neuroinflammation	neuroinflammation	NOUN
fnp-3806	613	21	,	,	PUNCT
fnp-3806	613	22	oxidative	oxidative	ADJ
fnp-3806	613	23	stress	stress	NOUN
fnp-3806	613	24	responses	response	NOUN
fnp-3806	613	25	,	,	PUNCT
fnp-3806	613	26	and	and	CCONJ
fnp-3806	613	27	bbb	bbb	NOUN
fnp-3806	613	28	dysfunction	dysfunction	NOUN
fnp-3806	613	29	(	(	PUNCT
fnp-3806	613	30	730	730	NUM
fnp-3806	613	31	-	-	SYM
fnp-3806	613	32	734	734	NUM
fnp-3806	613	33	)	)	PUNCT
fnp-3806	613	34	.	.	PUNCT
fnp-3806	614	1	microglia	microglia	NOUN
fnp-3806	614	2	and	and	CCONJ
fnp-3806	614	3	astrocytes	astrocyte	NOUN
fnp-3806	614	4	,	,	PUNCT
fnp-3806	614	5	together	together	ADV
fnp-3806	614	6	with	with	ADP
fnp-3806	614	7	neurons	neuron	NOUN
fnp-3806	614	8	and	and	CCONJ
fnp-3806	614	9	blood	blood	NOUN
fnp-3806	614	10	vessels	vessel	NOUN
fnp-3806	614	11	,	,	PUNCT
fnp-3806	614	12	participate	participate	VERB
fnp-3806	614	13	in	in	ADP
fnp-3806	614	14	the	the	DET
fnp-3806	614	15	process	process	NOUN
fnp-3806	614	16	of	of	ADP
fnp-3806	614	17	activation	activation	NOUN
fnp-3806	614	18	of	of	ADP
fnp-3806	614	19	inflammatory	inflammatory	ADJ
fnp-3806	614	20	responses	response	NOUN
fnp-3806	614	21	in	in	ADP
fnp-3806	614	22	aging	age	VERB
fnp-3806	614	23	and	and	CCONJ
fnp-3806	614	24	sad	sad	ADJ
fnp-3806	614	25	(	(	PUNCT
fnp-3806	614	26	735	735	NUM
fnp-3806	614	27	-	-	SYM
fnp-3806	614	28	737	737	NUM
fnp-3806	614	29	)	)	PUNCT
fnp-3806	614	30	.	.	PUNCT
fnp-3806	615	1	moreover	moreover	ADV
fnp-3806	615	2	,	,	PUNCT
fnp-3806	615	3	microglia	microglia	NOUN
fnp-3806	615	4	have	have	VERB
fnp-3806	615	5	the	the	DET
fnp-3806	615	6	capacity	capacity	NOUN
fnp-3806	615	7	to	to	PART
fnp-3806	615	8	transform	transform	VERB
fnp-3806	615	9	a	a	DET
fnp-3806	615	10	subset	subset	NOUN
fnp-3806	615	11	of	of	ADP
fnp-3806	615	12	reactive	reactive	ADJ
fnp-3806	615	13	astrocytes	astrocyte	NOUN
fnp-3806	615	14	through	through	ADP
fnp-3806	615	15	the	the	DET
fnp-3806	615	16	combination	combination	NOUN
fnp-3806	615	17	of	of	ADP
fnp-3806	615	18	il-1α	il-1α	PROPN
fnp-3806	615	19	,	,	PUNCT
fnp-3806	615	20	tnf	tnf	PROPN
fnp-3806	615	21	,	,	PUNCT
fnp-3806	615	22	and	and	CCONJ
fnp-3806	615	23	c1q	c1q	PROPN
fnp-3806	615	24	(	(	PUNCT
fnp-3806	615	25	738	738	NUM
fnp-3806	615	26	)	)	PUNCT
fnp-3806	615	27	.	.	PUNCT
fnp-3806	616	1	both	both	DET
fnp-3806	616	2	microglia	microglia	ADJ
fnp-3806	616	3	and	and	CCONJ
fnp-3806	616	4	astrocytes	astrocyte	NOUN
fnp-3806	616	5	are	be	AUX
fnp-3806	616	6	key	key	ADJ
fnp-3806	616	7	participants	participant	NOUN
fnp-3806	616	8	in	in	ADP
fnp-3806	616	9	neuroinflammation	neuroinflammation	NOUN
fnp-3806	616	10	in	in	ADP
fnp-3806	616	11	ad	ad	NOUN
fnp-3806	616	12	(	(	PUNCT
fnp-3806	616	13	739	739	NUM
fnp-3806	616	14	)	)	PUNCT
fnp-3806	616	15	.	.	PUNCT
fnp-3806	617	1	12a	12a	NOUN
fnp-3806	617	2	.	.	PUNCT
fnp-3806	618	1	astrocytes	astrocyte	NOUN
fnp-3806	618	2	astrocytes	astrocyte	NOUN
fnp-3806	618	3	are	be	AUX
fnp-3806	618	4	key	key	ADJ
fnp-3806	618	5	elements	element	NOUN
fnp-3806	618	6	in	in	ADP
fnp-3806	618	7	the	the	DET
fnp-3806	618	8	maintenance	maintenance	NOUN
fnp-3806	618	9	of	of	ADP
fnp-3806	618	10	the	the	DET
fnp-3806	618	11	central	central	ADJ
fnp-3806	618	12	nervous	nervous	ADJ
fnp-3806	618	13	system	system	NOUN
fnp-3806	618	14	(	(	PUNCT
fnp-3806	618	15	cns	cns	NOUN
fnp-3806	618	16	)	)	PUNCT
fnp-3806	618	17	due	due	ADP
fnp-3806	618	18	to	to	ADP
fnp-3806	618	19	their	their	PRON
fnp-3806	618	20	role	role	NOUN
fnp-3806	618	21	in	in	ADP
fnp-3806	618	22	brain	brain	NOUN
fnp-3806	618	23	homeostasis	homeostasis	NOUN
fnp-3806	618	24	at	at	ADP
fnp-3806	618	25	all	all	DET
fnp-3806	618	26	levels	level	NOUN
fnp-3806	618	27	of	of	ADP
fnp-3806	618	28	organization	organization	NOUN
fnp-3806	618	29	from	from	ADP
fnp-3806	618	30	molecular	molecular	ADJ
fnp-3806	618	31	to	to	ADP
fnp-3806	618	32	the	the	DET
fnp-3806	618	33	whole	whole	ADJ
fnp-3806	618	34	organ	organ	NOUN
fnp-3806	618	35	(	(	PUNCT
fnp-3806	618	36	740	740	NUM
fnp-3806	618	37	)	)	PUNCT
fnp-3806	618	38	.	.	PUNCT
fnp-3806	619	1	astrocytes	astrocyte	NOUN
fnp-3806	619	2	express	express	VERB
fnp-3806	619	3	neurotransmitter	neurotransmitter	NOUN
fnp-3806	619	4	receptors	receptor	NOUN
fnp-3806	619	5	,	,	PUNCT
fnp-3806	619	6	pumps	pump	NOUN
fnp-3806	619	7	,	,	PUNCT
fnp-3806	619	8	and	and	CCONJ
fnp-3806	619	9	transporters	transporter	NOUN
fnp-3806	619	10	at	at	ADP
fnp-3806	619	11	their	their	PRON
fnp-3806	619	12	plasmalemma	plasmalemma	NOUN
fnp-3806	619	13	,	,	PUNCT
fnp-3806	619	14	along	along	ADP
fnp-3806	619	15	with	with	ADP
fnp-3806	619	16	transporters	transporter	NOUN
fnp-3806	619	17	in	in	ADP
fnp-3806	619	18	the	the	DET
fnp-3806	619	19	endoplasmic	endoplasmic	ADJ
fnp-3806	619	20	reticulum	reticulum	NOUN
fnp-3806	619	21	and	and	CCONJ
fnp-3806	619	22	mitochondria	mitochondria	NOUN
fnp-3806	619	23	that	that	PRON
fnp-3806	619	24	regulate	regulate	VERB
fnp-3806	619	25	the	the	DET
fnp-3806	619	26	cytosolic	cytosolic	ADJ
fnp-3806	619	27	levels	level	NOUN
fnp-3806	619	28	of	of	ADP
fnp-3806	619	29	ions	ion	NOUN
fnp-3806	619	30	which	which	PRON
fnp-3806	619	31	underlie	underlie	VERB
fnp-3806	619	32	most	most	ADJ
fnp-3806	619	33	,	,	PUNCT
fnp-3806	619	34	if	if	SCONJ
fnp-3806	619	35	not	not	PART
fnp-3806	619	36	all	all	ADV
fnp-3806	619	37	,	,	PUNCT
fnp-3806	619	38	astroglial	astroglial	ADJ
fnp-3806	619	39	homeostatic	homeostatic	ADJ
fnp-3806	619	40	functions	function	NOUN
fnp-3806	619	41	(	(	PUNCT
fnp-3806	619	42	741	741	NUM
fnp-3806	619	43	)	)	PUNCT
fnp-3806	619	44	.	.	PUNCT
fnp-3806	620	1	with	with	ADP
fnp-3806	620	2	aging	age	VERB
fnp-3806	620	3	,	,	PUNCT
fnp-3806	620	4	astrocytes	astrocyte	NOUN
fnp-3806	620	5	show	show	VERB
fnp-3806	620	6	accumulation	accumulation	NOUN
fnp-3806	620	7	of	of	ADP
fnp-3806	620	8	lipofuscin	lipofuscin	PROPN
fnp-3806	620	9	,	,	PUNCT
fnp-3806	620	10	hypertrophy	hypertrophy	NOUN
fnp-3806	620	11	of	of	ADP
fnp-3806	620	12	cytoplasmic	cytoplasmic	ADJ
fnp-3806	620	13	filaments	filament	NOUN
fnp-3806	620	14	,	,	PUNCT
fnp-3806	620	15	increased	increase	VERB
fnp-3806	620	16	expression	expression	NOUN
fnp-3806	620	17	of	of	ADP
fnp-3806	620	18	glial	glial	ADJ
fnp-3806	620	19	fibrillary	fibrillary	ADJ
fnp-3806	620	20	acidic	acidic	ADJ
fnp-3806	620	21	protein	protein	NOUN
fnp-3806	620	22	(	(	PUNCT
fnp-3806	620	23	gfap	gfap	NOUN
fnp-3806	620	24	)	)	PUNCT
fnp-3806	620	25	,	,	PUNCT
fnp-3806	620	26	s100β	s100β	PROPN
fnp-3806	620	27	and	and	CCONJ
fnp-3806	620	28	vimentin	vimentin	NOUN
fnp-3806	620	29	,	,	PUNCT
fnp-3806	620	30	and	and	CCONJ
fnp-3806	620	31	modifications	modification	NOUN
fnp-3806	620	32	in	in	ADP
fnp-3806	620	33	morphology	morphology	NOUN
fnp-3806	620	34	and	and	CCONJ
fnp-3806	620	35	number	number	NOUN
fnp-3806	620	36	(	(	PUNCT
fnp-3806	620	37	742	742	NUM
fnp-3806	620	38	-	-	SYM
fnp-3806	620	39	744	744	NUM
fnp-3806	620	40	)	)	PUNCT
fnp-3806	620	41	.	.	PUNCT
fnp-3806	621	1	senescent	senescent	ADJ
fnp-3806	621	2	astrocytes	astrocyte	NOUN
fnp-3806	621	3	also	also	ADV
fnp-3806	621	4	exhibit	exhibit	VERB
fnp-3806	621	5	senescence	senescence	NOUN
fnp-3806	621	6	-	-	PUNCT
fnp-3806	621	7	associated	associate	VERB
fnp-3806	621	8	secretory	secretory	ADJ
fnp-3806	621	9	phenotype	phenotype	NOUN
fnp-3806	621	10	manifested	manifest	VERB
fnp-3806	621	11	by	by	ADP
fnp-3806	621	12	increased	increase	VERB
fnp-3806	621	13	production	production	NOUN
fnp-3806	621	14	of	of	ADP
fnp-3806	621	15	pro	pro	ADJ
fnp-3806	621	16	-	-	ADJ
fnp-3806	621	17	inflammatory	inflammatory	ADJ
fnp-3806	621	18	cytokines	cytokine	NOUN
fnp-3806	621	19	together	together	ADV
fnp-3806	621	20	with	with	ADP
fnp-3806	621	21	oxidative	oxidative	ADJ
fnp-3806	621	22	damage	damage	NOUN
fnp-3806	621	23	and	and	CCONJ
fnp-3806	621	24	increased	increase	VERB
fnp-3806	621	25	superoxide	superoxide	NOUN
fnp-3806	621	26	production	production	NOUN
fnp-3806	621	27	(	(	PUNCT
fnp-3806	621	28	745	745	NUM
fnp-3806	621	29	)	)	PUNCT
fnp-3806	621	30	.	.	PUNCT
fnp-3806	622	1	perivascular	perivascular	ADJ
fnp-3806	622	2	astrocyte	astrocyte	NOUN
fnp-3806	622	3	senescence	senescence	NOUN
fnp-3806	622	4	leads	lead	VERB
fnp-3806	622	5	to	to	ADP
fnp-3806	622	6	altered	altered	ADJ
fnp-3806	622	7	bbb	bbb	PROPN
fnp-3806	622	8	(	(	PUNCT
fnp-3806	622	9	746,747	746,747	NUM
fnp-3806	622	10	)	)	PUNCT
fnp-3806	622	11	.	.	PUNCT
fnp-3806	623	1	this	this	PRON
fnp-3806	623	2	is	be	AUX
fnp-3806	623	3	accompanied	accompany	VERB
fnp-3806	623	4	by	by	ADP
fnp-3806	623	5	reduced	reduced	ADJ
fnp-3806	623	6	expression	expression	NOUN
fnp-3806	623	7	of	of	ADP
fnp-3806	623	8	efflux	efflux	NOUN
fnp-3806	623	9	transporter	transporter	NOUN
fnp-3806	623	10	and	and	CCONJ
fnp-3806	623	11	increased	increase	VERB
fnp-3806	623	12	expression	expression	NOUN
fnp-3806	623	13	of	of	ADP
fnp-3806	623	14	influx	influx	NOUN
fnp-3806	623	15	transporter	transporter	NOUN
fnp-3806	623	16	receptors	receptor	NOUN
fnp-3806	623	17	for	for	ADP
fnp-3806	623	18	ages	age	NOUN
fnp-3806	623	19	.	.	PUNCT
fnp-3806	624	1	abnormal	abnormal	ADJ
fnp-3806	624	2	transport	transport	NOUN
fnp-3806	624	3	of	of	ADP
fnp-3806	624	4	proteins	protein	NOUN
fnp-3806	624	5	through	through	ADP
fnp-3806	624	6	blood	blood	NOUN
fnp-3806	624	7	vessels	vessel	NOUN
fnp-3806	624	8	affects	affect	VERB
fnp-3806	624	9	the	the	DET
fnp-3806	624	10	transfer	transfer	NOUN
fnp-3806	624	11	of	of	ADP
fnp-3806	624	12	β	β	NOUN
fnp-3806	624	13	-	-	NOUN
fnp-3806	624	14	amyloid	amyloid	NOUN
fnp-3806	624	15	,	,	PUNCT
fnp-3806	624	16	leading	lead	VERB
fnp-3806	624	17	to	to	ADP
fnp-3806	624	18	its	its	PRON
fnp-3806	624	19	accumulation	accumulation	NOUN
fnp-3806	624	20	in	in	ADP
fnp-3806	624	21	blood	blood	NOUN
fnp-3806	624	22	vessels	vessel	NOUN
fnp-3806	624	23	(	(	PUNCT
fnp-3806	624	24	748	748	NUM
fnp-3806	624	25	,	,	PUNCT
fnp-3806	624	26	749	749	NUM
fnp-3806	624	27	)	)	PUNCT
fnp-3806	624	28	.	.	PUNCT
fnp-3806	625	1	water	water	NOUN
fnp-3806	625	2	aquaporin	aquaporin	NOUN
fnp-3806	625	3	1	1	NUM
fnp-3806	625	4	(	(	PUNCT
fnp-3806	625	5	aqp1	aqp1	PROPN
fnp-3806	625	6	)	)	PUNCT
fnp-3806	625	7	expression	expression	NOUN
fnp-3806	625	8	in	in	ADP
fnp-3806	625	9	astrocytes	astrocyte	NOUN
fnp-3806	625	10	is	be	AUX
fnp-3806	625	11	also	also	ADV
fnp-3806	625	12	altered	alter	VERB
fnp-3806	625	13	in	in	ADP
fnp-3806	625	14	the	the	DET
fnp-3806	625	15	frontal	frontal	ADJ
fnp-3806	625	16	cortex	cortex	NOUN
fnp-3806	625	17	at	at	ADP
fnp-3806	625	18	nft	nft	PROPN
fnp-3806	625	19	stages	stage	NOUN
fnp-3806	625	20	i	i	PROPN
fnp-3806	625	21	-	-	PUNCT
fnp-3806	625	22	ii	ii	PROPN
fnp-3806	625	23	,	,	PUNCT
fnp-3806	625	24	suggesting	suggest	VERB
fnp-3806	625	25	early	early	ADJ
fnp-3806	625	26	impairment	impairment	NOUN
fnp-3806	625	27	of	of	ADP
fnp-3806	625	28	water	water	NOUN
fnp-3806	625	29	transport	transport	NOUN
fnp-3806	625	30	linked	link	VERB
fnp-3806	625	31	to	to	ADP
fnp-3806	625	32	ad	ad	NOUN
fnp-3806	625	33	-	-	PUNCT
fnp-3806	625	34	related	relate	VERB
fnp-3806	625	35	pathology	pathology	NOUN
fnp-3806	625	36	(	(	PUNCT
fnp-3806	625	37	750	750	NUM
fnp-3806	625	38	)	)	PUNCT
fnp-3806	625	39	.	.	PUNCT
fnp-3806	626	1	aqp4	aqp4	PROPN
fnp-3806	626	2	expression	expression	NOUN
fnp-3806	626	3	is	be	AUX
fnp-3806	626	4	altered	alter	VERB
fnp-3806	626	5	with	with	ADP
fnp-3806	626	6	aging	age	VERB
fnp-3806	626	7	and	and	CCONJ
fnp-3806	626	8	sad	sad	ADJ
fnp-3806	626	9	;	;	PUNCT
fnp-3806	626	10	loss	loss	NOUN
fnp-3806	626	11	of	of	ADP
fnp-3806	626	12	aqp4	aqp4	PROPN
fnp-3806	626	13	is	be	AUX
fnp-3806	626	14	associated	associate	VERB
fnp-3806	626	15	with	with	ADP
fnp-3806	626	16	increased	increase	VERB
fnp-3806	626	17	levels	level	NOUN
fnp-3806	626	18	of	of	ADP
fnp-3806	626	19	β	β	NOUN
fnp-3806	626	20	-	-	NOUN
fnp-3806	626	21	amyloid	amyloid	NOUN
fnp-3806	626	22	and	and	CCONJ
fnp-3806	626	23	tau	tau	PROPN
fnp-3806	626	24	,	,	PUNCT
fnp-3806	626	25	suggesting	suggest	VERB
fnp-3806	626	26	that	that	SCONJ
fnp-3806	626	27	loss	loss	NOUN
fnp-3806	626	28	of	of	ADP
fnp-3806	626	29	aqp4	aqp4	PROPN
fnp-3806	626	30	impairs	impair	VERB
fnp-3806	626	31	the	the	DET
fnp-3806	626	32	bbb	bbb	NOUN
fnp-3806	626	33	and	and	CCONJ
fnp-3806	626	34	the	the	DET
fnp-3806	626	35	gliolymphatic	gliolymphatic	ADJ
fnp-3806	626	36	barrier	barrier	NOUN
fnp-3806	626	37	(	(	PUNCT
fnp-3806	626	38	751	751	NUM
fnp-3806	626	39	)	)	PUNCT
fnp-3806	626	40	.	.	PUNCT
fnp-3806	627	1	astrogliosis	astrogliosis	NOUN
fnp-3806	627	2	and	and	CCONJ
fnp-3806	627	3	astrocyte	astrocyte	NOUN
fnp-3806	627	4	atrophy	atrophy	NOUN
fnp-3806	627	5	are	be	AUX
fnp-3806	627	6	relatively	relatively	ADV
fnp-3806	627	7	early	early	ADJ
fnp-3806	627	8	events	event	NOUN
fnp-3806	627	9	in	in	ADP
fnp-3806	627	10	ad	ad	NOUN
fnp-3806	627	11	(	(	PUNCT
fnp-3806	627	12	752	752	NUM
fnp-3806	627	13	-	-	NUM
fnp-3806	627	14	756	756	NUM
fnp-3806	627	15	)	)	PUNCT
fnp-3806	627	16	.	.	PUNCT
fnp-3806	628	1	reduced	reduce	VERB
fnp-3806	628	2	branching	branch	VERB
fnp-3806	628	3	and	and	CCONJ
fnp-3806	628	4	reduced	reduce	VERB
fnp-3806	628	5	connexin	connexin	NOUN
fnp-3806	628	6	43	43	NUM
fnp-3806	628	7	expression	expression	NOUN
fnp-3806	628	8	occur	occur	VERB
fnp-3806	628	9	in	in	ADP
fnp-3806	628	10	sad	sad	ADJ
fnp-3806	628	11	(	(	PUNCT
fnp-3806	628	12	757	757	NOUN
fnp-3806	628	13	)	)	PUNCT
fnp-3806	628	14	which	which	PRON
fnp-3806	628	15	may	may	AUX
fnp-3806	628	16	compromise	compromise	VERB
fnp-3806	628	17	the	the	DET
fnp-3806	628	18	extent	extent	NOUN
fnp-3806	628	19	of	of	ADP
fnp-3806	628	20	coverage	coverage	NOUN
fnp-3806	628	21	domain	domain	NOUN
fnp-3806	628	22	and	and	CCONJ
fnp-3806	628	23	synaptic	synaptic	ADJ
fnp-3806	628	24	function	function	NOUN
fnp-3806	628	25	in	in	ADP
fnp-3806	628	26	neighboring	neighboring	NOUN
fnp-3806	628	27	neurons	neuron	NOUN
fnp-3806	628	28	(	(	PUNCT
fnp-3806	628	29	758	758	NUM
fnp-3806	628	30	)	)	PUNCT
fnp-3806	628	31	.	.	PUNCT
fnp-3806	629	1	β	β	X
fnp-3806	629	2	-	-	PUNCT
fnp-3806	629	3	amyloid	amyloid	ADJ
fnp-3806	629	4	peptides	peptide	NOUN
fnp-3806	629	5	also	also	ADV
fnp-3806	629	6	induce	induce	VERB
fnp-3806	629	7	mitochondrial	mitochondrial	ADJ
fnp-3806	629	8	dysfunction	dysfunction	NOUN
fnp-3806	629	9	and	and	CCONJ
fnp-3806	629	10	oxidative	oxidative	ADJ
fnp-3806	629	11	stress	stress	NOUN
fnp-3806	629	12	in	in	ADP
fnp-3806	629	13	astrocytes	astrocyte	NOUN
fnp-3806	629	14	(	(	PUNCT
fnp-3806	629	15	759	759	NUM
fnp-3806	629	16	)	)	PUNCT
fnp-3806	629	17	.	.	PUNCT
fnp-3806	630	1	transcriptomics	transcriptomic	NOUN
fnp-3806	630	2	of	of	ADP
fnp-3806	630	3	laser	laser	NOUN
fnp-3806	630	4	-	-	PUNCT
fnp-3806	630	5	captured	capture	VERB
fnp-3806	630	6	microdissection	microdissection	NOUN
fnp-3806	630	7	using	use	VERB
fnp-3806	630	8	gfap	gfap	NOUN
fnp-3806	630	9	as	as	ADP
fnp-3806	630	10	a	a	DET
fnp-3806	630	11	marker	marker	NOUN
fnp-3806	630	12	revealed	reveal	VERB
fnp-3806	630	13	marked	mark	VERB
fnp-3806	630	14	dysregulation	dysregulation	NOUN
fnp-3806	630	15	of	of	ADP
fnp-3806	630	16	insulin	insulin	NOUN
fnp-3806	630	17	,	,	PUNCT
fnp-3806	630	18	phosphatidylinositol	phosphatidylinositol	NOUN
fnp-3806	630	19	3	3	NUM
fnp-3806	630	20	-	-	PUNCT
fnp-3806	630	21	kinase	kinase	NOUN
fnp-3806	630	22	(	(	PUNCT
fnp-3806	630	23	pi3k)/akt	pi3k)/akt	PROPN
fnp-3806	630	24	,	,	PUNCT
fnp-3806	630	25	and	and	CCONJ
fnp-3806	630	26	mitogen	mitogen	NOUN
fnp-3806	630	27	-	-	PUNCT
fnp-3806	630	28	activated	activate	VERB
fnp-3806	630	29	protein	protein	NOUN
fnp-3806	630	30	kinase	kinase	NOUN
fnp-3806	630	31	(	(	PUNCT
fnp-3806	630	32	mapk	mapk	NOUN
fnp-3806	630	33	)	)	PUNCT
fnp-3806	630	34	signaling	signal	VERB
fnp-3806	630	35	pathways	pathway	NOUN
fnp-3806	630	36	at	at	ADP
fnp-3806	630	37	advanced	advanced	ADJ
fnp-3806	630	38	braak	braak	NOUN
fnp-3806	630	39	stages	stage	NOUN
fnp-3806	630	40	of	of	ADP
fnp-3806	630	41	the	the	DET
fnp-3806	630	42	disease	disease	NOUN
fnp-3806	630	43	;	;	PUNCT
fnp-3806	630	44	minor	minor	ADJ
fnp-3806	630	45	and	and	CCONJ
fnp-3806	630	46	different	different	ADJ
fnp-3806	630	47	abnormalities	abnormality	NOUN
fnp-3806	630	48	were	be	AUX
fnp-3806	630	49	observed	observe	VERB
fnp-3806	630	50	at	at	ADP
fnp-3806	630	51	earlier	early	ADJ
fnp-3806	630	52	stages	stage	NOUN
fnp-3806	630	53	,	,	PUNCT
fnp-3806	630	54	indicating	indicate	VERB
fnp-3806	630	55	different	different	ADJ
fnp-3806	630	56	responses	response	NOUN
fnp-3806	630	57	of	of	ADP
fnp-3806	630	58	astrocytes	astrocyte	NOUN
fnp-3806	630	59	along	along	ADP
fnp-3806	630	60	disease	disease	NOUN
fnp-3806	630	61	progression	progression	NOUN
fnp-3806	630	62	(	(	PUNCT
fnp-3806	630	63	760	760	NUM
fnp-3806	630	64	)	)	PUNCT
fnp-3806	630	65	.	.	PUNCT
fnp-3806	631	1	recent	recent	ADJ
fnp-3806	631	2	transcriptomic	transcriptomic	ADJ
fnp-3806	631	3	studies	study	NOUN
fnp-3806	631	4	in	in	ADP
fnp-3806	631	5	sad	sad	ADJ
fnp-3806	631	6	have	have	AUX
fnp-3806	631	7	shown	show	VERB
fnp-3806	631	8	upregulation	upregulation	NOUN
fnp-3806	631	9	of	of	ADP
fnp-3806	631	10	genes	gene	NOUN
fnp-3806	631	11	related	relate	VERB
fnp-3806	631	12	to	to	ADP
fnp-3806	631	13	perisynaptic	perisynaptic	ADJ
fnp-3806	631	14	astrocytic	astrocytic	ADJ
fnp-3806	631	15	processes	process	NOUN
fnp-3806	631	16	and	and	CCONJ
fnp-3806	631	17	downregulation	downregulation	NOUN
fnp-3806	631	18	of	of	ADP
fnp-3806	631	19	genes	gene	NOUN
fnp-3806	631	20	encoding	encode	VERB
fnp-3806	631	21	endolysosomal	endolysosomal	ADJ
fnp-3806	631	22	and	and	CCONJ
fnp-3806	631	23	mitochondrial	mitochondrial	ADJ
fnp-3806	631	24	proteins	protein	NOUN
fnp-3806	631	25	;	;	PUNCT
fnp-3806	631	26	downregulation	downregulation	NOUN
fnp-3806	631	27	of	of	ADP
fnp-3806	631	28	astrocytic	astrocytic	ADJ
fnp-3806	631	29	mitochondrial	mitochondrial	ADJ
fnp-3806	631	30	genes	gene	NOUN
fnp-3806	631	31	inversely	inversely	ADV
fnp-3806	631	32	correlates	correlate	VERB
fnp-3806	631	33	with	with	ADP
fnp-3806	631	34	the	the	DET
fnp-3806	631	35	disease	disease	NOUN
fnp-3806	631	36	stages	stage	NOUN
fnp-3806	631	37	defined	define	VERB
fnp-3806	631	38	by	by	ADP
fnp-3806	631	39	braak	braak	NOUN
fnp-3806	631	40	and	and	CCONJ
fnp-3806	631	41	cerad	cerad	VERB
fnp-3806	631	42	scoring	scoring	NOUN
fnp-3806	631	43	(	(	PUNCT
fnp-3806	631	44	761	761	NUM
fnp-3806	631	45	)	)	PUNCT
fnp-3806	631	46	.	.	PUNCT
fnp-3806	632	1	reactive	reactive	ADJ
fnp-3806	632	2	astrocytes	astrocyte	NOUN
fnp-3806	632	3	are	be	AUX
fnp-3806	632	4	found	find	VERB
fnp-3806	632	5	mainly	mainly	ADV
fnp-3806	632	6	around	around	ADP
fnp-3806	632	7	aβ	aβ	ADP
fnp-3806	632	8	deposits	deposit	NOUN
fnp-3806	632	9	in	in	ADP
fnp-3806	632	10	sps	sps	PROPN
fnp-3806	632	11	and	and	CCONJ
fnp-3806	632	12	blood	blood	NOUN
fnp-3806	632	13	vessels	vessel	NOUN
fnp-3806	632	14	(	(	PUNCT
fnp-3806	632	15	752	752	NUM
fnp-3806	632	16	,	,	PUNCT
fnp-3806	632	17	762	762	NUM
fnp-3806	632	18	,	,	PUNCT
fnp-3806	632	19	763	763	NUM
fnp-3806	632	20	)	)	PUNCT
fnp-3806	632	21	and	and	CCONJ
fnp-3806	632	22	in	in	ADP
fnp-3806	632	23	areas	area	NOUN
fnp-3806	632	24	without	without	ADP
fnp-3806	632	25	plaques	plaque	NOUN
fnp-3806	632	26	then	then	ADV
fnp-3806	632	27	distributed	distribute	VERB
fnp-3806	632	28	in	in	ADP
fnp-3806	632	29	a	a	DET
fnp-3806	632	30	layered	layered	ADJ
fnp-3806	632	31	pattern	pattern	NOUN
fnp-3806	632	32	(	(	PUNCT
fnp-3806	632	33	762	762	NUM
fnp-3806	632	34	,	,	PUNCT
fnp-3806	632	35	764	764	NUM
fnp-3806	632	36	)	)	PUNCT
fnp-3806	632	37	.	.	PUNCT
fnp-3806	633	1	in	in	ADP
fnp-3806	633	2	response	response	NOUN
fnp-3806	633	3	to	to	PART
fnp-3806	633	4	vascular	vascular	VERB
fnp-3806	633	5	β	β	NOUN
fnp-3806	633	6	-	-	NOUN
fnp-3806	633	7	amyloid	amyloid	ADJ
fnp-3806	633	8	deposition	deposition	NOUN
fnp-3806	633	9	,	,	PUNCT
fnp-3806	633	10	astrocytes	astrocyte	NOUN
fnp-3806	633	11	produce	produce	VERB
fnp-3806	633	12	cytokines	cytokine	NOUN
fnp-3806	633	13	,	,	PUNCT
fnp-3806	633	14	metabolizing	metabolize	VERB
fnp-3806	633	15	enzymes	enzyme	NOUN
fnp-3806	633	16	,	,	PUNCT
fnp-3806	633	17	and	and	CCONJ
fnp-3806	633	18	ros	ros	PROPN
fnp-3806	633	19	which	which	PRON
fnp-3806	633	20	in	in	ADP
fnp-3806	633	21	turn	turn	NOUN
fnp-3806	633	22	contribute	contribute	VERB
fnp-3806	633	23	to	to	ADP
fnp-3806	633	24	altered	alter	VERB
fnp-3806	633	25	bbb	bbb	PROPN
fnp-3806	633	26	and	and	CCONJ
fnp-3806	633	27	perivascular	perivascular	ADJ
fnp-3806	633	28	astrocytic	astrocytic	ADJ
fnp-3806	633	29	function	function	NOUN
fnp-3806	633	30	(	(	PUNCT
fnp-3806	633	31	765	765	NUM
fnp-3806	633	32	-	-	SYM
fnp-3806	633	33	769	769	NUM
fnp-3806	633	34	)	)	PUNCT
fnp-3806	633	35	.	.	PUNCT
fnp-3806	634	1	reactive	reactive	ADJ
fnp-3806	634	2	astrocytes	astrocyte	NOUN
fnp-3806	634	3	may	may	AUX
fnp-3806	634	4	contain	contain	VERB
fnp-3806	634	5	aβ	aβ	ADP
fnp-3806	634	6	(	(	PUNCT
fnp-3806	634	7	770	770	NUM
fnp-3806	634	8	-	-	SYM
fnp-3806	634	9	772	772	NUM
fnp-3806	634	10	)	)	PUNCT
fnp-3806	634	11	and	and	CCONJ
fnp-3806	634	12	n	n	CCONJ
fnp-3806	634	13	-	-	PUNCT
fnp-3806	634	14	terminal	terminal	NOUN
fnp-3806	634	15	truncated	truncated	ADJ
fnp-3806	634	16	β	β	NOUN
fnp-3806	634	17	-	-	NOUN
fnp-3806	634	18	amyloid	amyloid	NOUN
fnp-3806	634	19	(	(	PUNCT
fnp-3806	634	20	773	773	NUM
fnp-3806	634	21	)	)	PUNCT
fnp-3806	634	22	,	,	PUNCT
fnp-3806	634	23	and	and	CCONJ
fnp-3806	634	24	they	they	PRON
fnp-3806	634	25	have	have	VERB
fnp-3806	634	26	the	the	DET
fnp-3806	634	27	capacity	capacity	NOUN
fnp-3806	634	28	to	to	PART
fnp-3806	634	29	internalize	internalize	VERB
fnp-3806	634	30	and	and	CCONJ
fnp-3806	634	31	degrade	degrade	VERB
fnp-3806	634	32	β	β	NOUN
fnp-3806	634	33	-	-	ADJ
fnp-3806	634	34	amyloid	amyloid	ADJ
fnp-3806	634	35	fibrils	fibril	NOUN
fnp-3806	634	36	(	(	PUNCT
fnp-3806	634	37	774	774	NUM
fnp-3806	634	38	)	)	PUNCT
fnp-3806	634	39	.	.	PUNCT
fnp-3806	635	1	activation	activation	NOUN
fnp-3806	635	2	of	of	ADP
fnp-3806	635	3	metalloproteinases	metalloproteinase	NOUN
fnp-3806	635	4	(	(	PUNCT
fnp-3806	635	5	765	765	NUM
fnp-3806	635	6	,	,	PUNCT
fnp-3806	635	7	775	775	NUM
fnp-3806	635	8	)	)	PUNCT
fnp-3806	635	9	and	and	CCONJ
fnp-3806	635	10	lysosomal	lysosomal	ADJ
fnp-3806	635	11	degradation	degradation	NOUN
fnp-3806	635	12	(	(	PUNCT
fnp-3806	635	13	776	776	NUM
fnp-3806	635	14	,	,	PUNCT
fnp-3806	635	15	777	777	NUM
fnp-3806	635	16	)	)	PUNCT
fnp-3806	635	17	are	be	AUX
fnp-3806	635	18	the	the	DET
fnp-3806	635	19	main	main	ADJ
fnp-3806	635	20	complementary	complementary	ADJ
fnp-3806	635	21	mechanisms	mechanism	NOUN
fnp-3806	635	22	by	by	ADP
fnp-3806	635	23	which	which	PRON
fnp-3806	635	24	astrocytes	astrocyte	NOUN
fnp-3806	635	25	degrade	degrade	VERB
fnp-3806	635	26	β	β	NOUN
fnp-3806	635	27	-	-	NOUN
fnp-3806	635	28	amyloid	amyloid	NOUN
fnp-3806	635	29	.	.	PUNCT
fnp-3806	636	1	in	in	ADP
fnp-3806	636	2	addition	addition	NOUN
fnp-3806	636	3	,	,	PUNCT
fnp-3806	636	4	bace	bace	PROPN
fnp-3806	636	5	may	may	AUX
fnp-3806	636	6	be	be	AUX
fnp-3806	636	7	expressed	express	VERB
fnp-3806	636	8	in	in	ADP
fnp-3806	636	9	astrocytes	astrocyte	NOUN
fnp-3806	636	10	under	under	ADP
fnp-3806	636	11	appropriate	appropriate	ADJ
fnp-3806	636	12	conditions	condition	NOUN
fnp-3806	636	13	,	,	PUNCT
fnp-3806	636	14	facilitating	facilitate	VERB
fnp-3806	636	15	the	the	DET
fnp-3806	636	16	generation	generation	NOUN
fnp-3806	636	17	of	of	ADP
fnp-3806	636	18	β	β	NOUN
fnp-3806	636	19	-	-	NOUN
fnp-3806	636	20	amyloid	amyloid	NOUN
fnp-3806	636	21	in	in	ADP
fnp-3806	636	22	these	these	DET
fnp-3806	636	23	cells	cell	NOUN
fnp-3806	636	24	(	(	PUNCT
fnp-3806	636	25	752	752	NUM
fnp-3806	636	26	,	,	PUNCT
fnp-3806	636	27	778	778	NUM
fnp-3806	636	28	)	)	PUNCT
fnp-3806	636	29	.	.	PUNCT
fnp-3806	637	1	acquisition	acquisition	NOUN
fnp-3806	637	2	of	of	ADP
fnp-3806	637	3	a	a	DET
fnp-3806	637	4	pro	pro	ADJ
fnp-3806	637	5	-	-	ADJ
fnp-3806	637	6	inflammatory	inflammatory	ADJ
fnp-3806	637	7	profile	profile	NOUN
fnp-3806	637	8	along	along	ADP
fnp-3806	637	9	with	with	ADP
fnp-3806	637	10	activation	activation	NOUN
fnp-3806	637	11	of	of	ADP
fnp-3806	637	12	the	the	DET
fnp-3806	637	13	β	β	NOUN
fnp-3806	637	14	-	-	ADJ
fnp-3806	637	15	amyloidogenic	amyloidogenic	ADJ
fnp-3806	637	16	pathway	pathway	NOUN
fnp-3806	637	17	further	far	ADV
fnp-3806	637	18	potentiates	potentiate	VERB
fnp-3806	637	19	toxicity	toxicity	NOUN
fnp-3806	637	20	of	of	ADP
fnp-3806	637	21	a	a	DET
fnp-3806	637	22	subpopulation	subpopulation	NOUN
fnp-3806	637	23	of	of	ADP
fnp-3806	637	24	astrocytes	astrocyte	NOUN
fnp-3806	637	25	in	in	ADP
fnp-3806	637	26	ad	ad	NOUN
fnp-3806	637	27	(	(	PUNCT
fnp-3806	637	28	779	779	NUM
fnp-3806	637	29	)	)	PUNCT
fnp-3806	637	30	.	.	PUNCT
fnp-3806	638	1	curiously	curiously	ADV
fnp-3806	638	2	,	,	PUNCT
fnp-3806	638	3	β	β	X
fnp-3806	638	4	-	-	NOUN
fnp-3806	638	5	amyloid	amyloid	NOUN
fnp-3806	638	6	seems	seem	VERB
fnp-3806	638	7	to	to	PART
fnp-3806	638	8	impair	impair	VERB
fnp-3806	638	9	the	the	DET
fnp-3806	638	10	phagocytosis	phagocytosis	NOUN
fnp-3806	638	11	of	of	ADP
fnp-3806	638	12	dystrophic	dystrophic	ADJ
fnp-3806	638	13	synapses	synapsis	NOUN
fnp-3806	638	14	by	by	ADP
fnp-3806	638	15	astrocytes	astrocyte	NOUN
fnp-3806	638	16	(	(	PUNCT
fnp-3806	638	17	780	780	NUM
fnp-3806	638	18	)	)	PUNCT
fnp-3806	638	19	.	.	PUNCT
fnp-3806	639	1	astrocytes	astrocyte	NOUN
fnp-3806	639	2	bearing	bear	VERB
fnp-3806	639	3	β	β	NOUN
fnp-3806	639	4	-	-	NOUN
fnp-3806	639	5	amyloid	amyloid	ADJ
fnp-3806	639	6	show	show	NOUN
fnp-3806	639	7	abnormal	abnormal	ADJ
fnp-3806	639	8	calcium	calcium	NOUN
fnp-3806	639	9	homeostasis	homeostasis	NOUN
fnp-3806	639	10	(	(	PUNCT
fnp-3806	639	11	758	758	NUM
fnp-3806	639	12	,	,	PUNCT
fnp-3806	639	13	759	759	NUM
fnp-3806	639	14	,	,	PUNCT
fnp-3806	639	15	781	781	NUM
fnp-3806	639	16	-	-	NUM
fnp-3806	639	17	783	783	NUM
fnp-3806	639	18	)	)	PUNCT
fnp-3806	639	19	.	.	PUNCT
fnp-3806	640	1	in	in	ADP
fnp-3806	640	2	addition	addition	NOUN
fnp-3806	640	3	,	,	PUNCT
fnp-3806	640	4	β	β	NOUN
fnp-3806	640	5	-	-	NOUN
fnp-3806	640	6	amyloid	amyloid	NOUN
fnp-3806	640	7	-	-	PUNCT
fnp-3806	640	8	induced	induce	VERB
fnp-3806	640	9	glutamate	glutamate	NOUN
fnp-3806	640	10	release	release	NOUN
fnp-3806	640	11	by	by	ADP
fnp-3806	640	12	astrocytes	astrocyte	NOUN
fnp-3806	640	13	may	may	AUX
fnp-3806	640	14	contribute	contribute	VERB
fnp-3806	640	15	to	to	ADP
fnp-3806	640	16	neuronal	neuronal	ADJ
fnp-3806	640	17	excitatory	excitatory	ADJ
fnp-3806	640	18	damage	damage	NOUN
fnp-3806	640	19	(	(	PUNCT
fnp-3806	640	20	784	784	NUM
fnp-3806	640	21	)	)	PUNCT
fnp-3806	640	22	.	.	PUNCT
fnp-3806	641	1	de	de	NOUN
fnp-3806	641	2	-	-	NOUN
fnp-3806	641	3	regulation	regulation	NOUN
fnp-3806	641	4	of	of	ADP
fnp-3806	641	5	specific	specific	ADJ
fnp-3806	641	6	metabotropic	metabotropic	NOUN
fnp-3806	641	7	glutamate	glutamate	NOUN
fnp-3806	641	8	receptors	receptor	NOUN
fnp-3806	641	9	in	in	ADP
fnp-3806	641	10	astroglia	astroglia	PROPN
fnp-3806	641	11	is	be	AUX
fnp-3806	641	12	also	also	ADV
fnp-3806	641	13	a	a	DET
fnp-3806	641	14	putative	putative	ADJ
fnp-3806	641	15	harmful	harmful	ADJ
fnp-3806	641	16	effect	effect	NOUN
fnp-3806	641	17	of	of	ADP
fnp-3806	641	18	β	β	NOUN
fnp-3806	641	19	-	-	NOUN
fnp-3806	641	20	amyloid	amyloid	NOUN
fnp-3806	641	21	(	(	PUNCT
fnp-3806	641	22	785	785	NUM
fnp-3806	641	23	)	)	PUNCT
fnp-3806	641	24	.	.	PUNCT
fnp-3806	642	1	nmdars	nmdar	NOUN
fnp-3806	642	2	are	be	AUX
fnp-3806	642	3	expressed	express	VERB
fnp-3806	642	4	in	in	ADP
fnp-3806	642	5	a	a	DET
fnp-3806	642	6	sub	sub	NOUN
fnp-3806	642	7	-	-	NOUN
fnp-3806	642	8	population	population	NOUN
fnp-3806	642	9	of	of	ADP
fnp-3806	642	10	astrocytes	astrocyte	NOUN
fnp-3806	642	11	in	in	ADP
fnp-3806	642	12	the	the	DET
fnp-3806	642	13	cortex	cortex	NOUN
fnp-3806	642	14	and	and	CCONJ
fnp-3806	642	15	spinal	spinal	ADJ
fnp-3806	642	16	cord	cord	NOUN
fnp-3806	642	17	.	.	PUNCT
fnp-3806	643	1	these	these	DET
fnp-3806	643	2	receptors	receptor	NOUN
fnp-3806	643	3	are	be	AUX
fnp-3806	643	4	composed	compose	VERB
fnp-3806	643	5	of	of	ADP
fnp-3806	643	6	two	two	NUM
fnp-3806	643	7	glun1	glun1	NOUN
fnp-3806	643	8	,	,	PUNCT
fnp-3806	643	9	one	one	NUM
fnp-3806	643	10	glun2c	glun2c	NOUN
fnp-3806	643	11	or	or	CCONJ
fnp-3806	643	12	d	d	NOUN
fnp-3806	643	13	,	,	PUNCT
fnp-3806	643	14	and	and	CCONJ
fnp-3806	643	15	one	one	NUM
fnp-3806	643	16	glun3	glun3	NOUN
fnp-3806	643	17	subunits	subunit	NOUN
fnp-3806	643	18	.	.	PUNCT
fnp-3806	644	1	this	this	DET
fnp-3806	644	2	composition	composition	NOUN
fnp-3806	644	3	makes	make	VERB
fnp-3806	644	4	astroglial	astroglial	ADJ
fnp-3806	644	5	nmdars	nmdar	NOUN
fnp-3806	644	6	operational	operational	ADJ
fnp-3806	644	7	,	,	PUNCT
fnp-3806	644	8	modulating	modulate	VERB
fnp-3806	644	9	resting	rest	VERB
fnp-3806	644	10	membrane	membrane	NOUN
fnp-3806	644	11	potential	potential	NOUN
fnp-3806	644	12	(	(	PUNCT
fnp-3806	644	13	786	786	NUM
fnp-3806	644	14	)	)	PUNCT
fnp-3806	644	15	.	.	PUNCT
fnp-3806	645	1	eaat2	eaat2	NOUN
fnp-3806	645	2	clears	clear	VERB
fnp-3806	645	3	excess	excess	ADJ
fnp-3806	645	4	extracellular	extracellular	ADJ
fnp-3806	645	5	glutamate	glutamate	NOUN
fnp-3806	645	6	from	from	ADP
fnp-3806	645	7	the	the	DET
fnp-3806	645	8	synaptic	synaptic	ADJ
fnp-3806	645	9	cleft	cleft	NOUN
fnp-3806	645	10	and	and	CCONJ
fnp-3806	645	11	extrasynaptic	extrasynaptic	ADJ
fnp-3806	645	12	sites	site	NOUN
fnp-3806	645	13	via	via	ADP
fnp-3806	645	14	glutamate	glutamate	NOUN
fnp-3806	645	15	re	re	NOUN
fnp-3806	645	16	-	-	NOUN
fnp-3806	645	17	uptake	uptake	ADJ
fnp-3806	645	18	by	by	ADP
fnp-3806	645	19	glial	glial	ADJ
fnp-3806	645	20	cells	cell	NOUN
fnp-3806	645	21	and	and	CCONJ
fnp-3806	645	22	neurons	neuron	NOUN
fnp-3806	645	23	to	to	PART
fnp-3806	645	24	prevent	prevent	VERB
fnp-3806	645	25	neuronal	neuronal	ADJ
fnp-3806	645	26	hyperexcitability	hyperexcitability	NOUN
fnp-3806	645	27	and	and	CCONJ
fnp-3806	645	28	excitotoxicity	excitotoxicity	NOUN
fnp-3806	645	29	.	.	PUNCT
fnp-3806	646	1	oxidative	oxidative	ADJ
fnp-3806	646	2	damage	damage	NOUN
fnp-3806	646	3	,	,	PUNCT
fnp-3806	646	4	splice	splice	NOUN
fnp-3806	646	5	variants	variant	NOUN
fnp-3806	646	6	,	,	PUNCT
fnp-3806	646	7	and	and	CCONJ
fnp-3806	646	8	altered	alter	VERB
fnp-3806	646	9	solubility	solubility	NOUN
fnp-3806	646	10	of	of	ADP
fnp-3806	646	11	eaat2	eaat2	NOUN
fnp-3806	646	12	may	may	AUX
fnp-3806	646	13	lead	lead	VERB
fnp-3806	646	14	to	to	ADP
fnp-3806	646	15	functional	functional	ADJ
fnp-3806	646	16	alterations	alteration	NOUN
fnp-3806	646	17	of	of	ADP
fnp-3806	646	18	glutamate	glutamate	ADJ
fnp-3806	646	19	transporters	transporter	NOUN
fnp-3806	646	20	in	in	ADP
fnp-3806	646	21	ad	ad	NOUN
fnp-3806	646	22	(	(	PUNCT
fnp-3806	646	23	787	787	NUM
fnp-3806	646	24	-	-	SYM
fnp-3806	646	25	789	789	NUM
fnp-3806	646	26	)	)	PUNCT
fnp-3806	646	27	.	.	PUNCT
fnp-3806	647	1	moreover	moreover	ADV
fnp-3806	647	2	,	,	PUNCT
fnp-3806	647	3	eaat2	eaat2	NOUN
fnp-3806	647	4	expression	expression	NOUN
fnp-3806	647	5	is	be	AUX
fnp-3806	647	6	reduced	reduce	VERB
fnp-3806	647	7	with	with	ADP
fnp-3806	647	8	disease	disease	NOUN
fnp-3806	647	9	progression	progression	NOUN
fnp-3806	647	10	in	in	ADP
fnp-3806	647	11	parallel	parallel	NOUN
fnp-3806	647	12	with	with	ADP
fnp-3806	647	13	increased	increase	VERB
fnp-3806	647	14	gfap	gfap	ADJ
fnp-3806	647	15	expression	expression	NOUN
fnp-3806	647	16	in	in	ADP
fnp-3806	647	17	sad	sad	ADJ
fnp-3806	647	18	(	(	PUNCT
fnp-3806	647	19	762	762	NUM
fnp-3806	647	20	,	,	PUNCT
fnp-3806	647	21	790	790	NUM
fnp-3806	647	22	,	,	PUNCT
fnp-3806	647	23	791	791	NUM
fnp-3806	647	24	)	)	PUNCT
fnp-3806	647	25	.	.	PUNCT
fnp-3806	648	1	furthermore	furthermore	ADV
fnp-3806	648	2	,	,	PUNCT
fnp-3806	648	3	astrocytes	astrocyte	NOUN
fnp-3806	648	4	surrounding	surround	VERB
fnp-3806	648	5	sps	sps	PROPN
fnp-3806	648	6	show	show	NOUN
fnp-3806	648	7	altered	alter	VERB
fnp-3806	648	8	immunoproteasome	immunoproteasome	NOUN
fnp-3806	648	9	markers	marker	NOUN
fnp-3806	648	10	,	,	PUNCT
fnp-3806	648	11	and	and	CCONJ
fnp-3806	648	12	augmented	augment	VERB
fnp-3806	648	13	expression	expression	NOUN
fnp-3806	648	14	of	of	ADP
fnp-3806	648	15	cytokines	cytokine	NOUN
fnp-3806	648	16	and	and	CCONJ
fnp-3806	648	17	mediators	mediator	NOUN
fnp-3806	648	18	of	of	ADP
fnp-3806	648	19	the	the	DET
fnp-3806	648	20	immune	immune	ADJ
fnp-3806	648	21	response	response	NOUN
fnp-3806	648	22	(	(	PUNCT
fnp-3806	648	23	721	721	NUM
fnp-3806	648	24	,	,	PUNCT
fnp-3806	648	25	735	735	NUM
fnp-3806	648	26	,	,	PUNCT
fnp-3806	648	27	792	792	NUM
fnp-3806	648	28	,	,	PUNCT
fnp-3806	648	29	793	793	NUM
fnp-3806	648	30	)	)	PUNCT
fnp-3806	648	31	.	.	PUNCT
fnp-3806	649	1	reactive	reactive	ADJ
fnp-3806	649	2	astrocytes	astrocyte	NOUN
fnp-3806	649	3	in	in	ADP
fnp-3806	649	4	sad	sad	ADJ
fnp-3806	649	5	also	also	ADV
fnp-3806	649	6	have	have	VERB
fnp-3806	649	7	higher	high	ADJ
fnp-3806	649	8	levels	level	NOUN
fnp-3806	649	9	of	of	ADP
fnp-3806	649	10	complement	complement	NOUN
fnp-3806	649	11	component	component	NOUN
fnp-3806	649	12	c3	c3	NOUN
fnp-3806	649	13	which	which	PRON
fnp-3806	649	14	is	be	AUX
fnp-3806	649	15	required	require	VERB
fnp-3806	649	16	for	for	ADP
fnp-3806	649	17	both	both	CCONJ
fnp-3806	649	18	classical	classical	ADJ
fnp-3806	649	19	and	and	CCONJ
fnp-3806	649	20	alternative	alternative	ADJ
fnp-3806	649	21	complement	complement	NOUN
fnp-3806	649	22	activation	activation	NOUN
fnp-3806	649	23	pathways	pathway	NOUN
fnp-3806	649	24	(	(	PUNCT
fnp-3806	649	25	794	794	NUM
fnp-3806	649	26	)	)	PUNCT
fnp-3806	649	27	.	.	PUNCT
fnp-3806	650	1	changes	change	NOUN
fnp-3806	650	2	in	in	ADP
fnp-3806	650	3	the	the	DET
fnp-3806	650	4	morphology	morphology	NOUN
fnp-3806	650	5	of	of	ADP
fnp-3806	650	6	astrocytes	astrocyte	NOUN
fnp-3806	650	7	are	be	AUX
fnp-3806	650	8	accompanied	accompany	VERB
fnp-3806	650	9	by	by	ADP
fnp-3806	650	10	alterations	alteration	NOUN
fnp-3806	650	11	in	in	ADP
fnp-3806	650	12	the	the	DET
fnp-3806	650	13	regulation	regulation	NOUN
fnp-3806	650	14	and	and	CCONJ
fnp-3806	650	15	expression	expression	NOUN
fnp-3806	650	16	of	of	ADP
fnp-3806	650	17	gfap	gfap	ADJ
fnp-3806	650	18	and	and	CCONJ
fnp-3806	650	19	other	other	ADJ
fnp-3806	650	20	astrocyte	astrocyte	NOUN
fnp-3806	650	21	markers	marker	NOUN
fnp-3806	650	22	in	in	ADP
fnp-3806	650	23	cases	case	NOUN
fnp-3806	650	24	with	with	ADP
fnp-3806	650	25	mci	mci	PROPN
fnp-3806	650	26	and	and	CCONJ
fnp-3806	650	27	in	in	ADP
fnp-3806	650	28	pre	pre	ADJ
fnp-3806	650	29	-	-	ADJ
fnp-3806	650	30	clinical	clinical	ADJ
fnp-3806	650	31	ad	ad	NOUN
fnp-3806	650	32	(	(	PUNCT
fnp-3806	650	33	791	791	NUM
fnp-3806	650	34	,	,	PUNCT
fnp-3806	650	35	795	795	NUM
fnp-3806	650	36	-	-	SYM
fnp-3806	650	37	797	797	NUM
fnp-3806	650	38	)	)	PUNCT
fnp-3806	650	39	.	.	PUNCT
fnp-3806	651	1	these	these	DET
fnp-3806	651	2	changes	change	NOUN
fnp-3806	651	3	are	be	AUX
fnp-3806	651	4	preceded	precede	VERB
fnp-3806	651	5	by	by	ADP
fnp-3806	651	6	expression	expression	NOUN
fnp-3806	651	7	of	of	ADP
fnp-3806	651	8	various	various	ADJ
fnp-3806	651	9	cytokines	cytokine	NOUN
fnp-3806	651	10	and	and	CCONJ
fnp-3806	651	11	components	component	NOUN
fnp-3806	651	12	of	of	ADP
fnp-3806	651	13	the	the	DET
fnp-3806	651	14	inflammatory	inflammatory	ADJ
fnp-3806	651	15	response	response	NOUN
fnp-3806	651	16	(	(	PUNCT
fnp-3806	651	17	793	793	NUM
fnp-3806	651	18	,	,	PUNCT
fnp-3806	651	19	798	798	NUM
fnp-3806	651	20	)	)	PUNCT
fnp-3806	651	21	.	.	PUNCT
fnp-3806	652	1	astrocytic	astrocytic	ADJ
fnp-3806	652	2	responses	response	NOUN
fnp-3806	652	3	are	be	AUX
fnp-3806	652	4	not	not	PART
fnp-3806	652	5	homogeneous	homogeneous	ADJ
fnp-3806	652	6	but	but	CCONJ
fnp-3806	652	7	rather	rather	ADV
fnp-3806	652	8	variable	variable	ADJ
fnp-3806	652	9	,	,	PUNCT
fnp-3806	652	10	even	even	ADV
fnp-3806	652	11	in	in	ADP
fnp-3806	652	12	the	the	DET
fnp-3806	652	13	same	same	ADJ
fnp-3806	652	14	region	region	NOUN
fnp-3806	652	15	(	(	PUNCT
fnp-3806	652	16	799	799	NUM
fnp-3806	652	17	-	-	SYM
fnp-3806	652	18	801	801	NUM
fnp-3806	652	19	)	)	PUNCT
fnp-3806	652	20	.	.	PUNCT
fnp-3806	653	1	as	as	ADP
fnp-3806	653	2	for	for	ADP
fnp-3806	653	3	m1	m1	PROPN
fnp-3806	653	4	and	and	CCONJ
fnp-3806	653	5	m2	m2	PROPN
fnp-3806	653	6	suggested	suggest	VERB
fnp-3806	653	7	phenotypes	phenotype	NOUN
fnp-3806	653	8	for	for	ADP
fnp-3806	653	9	microglia	microglia	NOUN
fnp-3806	653	10	(	(	PUNCT
fnp-3806	653	11	see	see	VERB
fnp-3806	653	12	section	section	NOUN
fnp-3806	653	13	12b	12b	NOUN
fnp-3806	653	14	)	)	PUNCT
fnp-3806	653	15	,	,	PUNCT
fnp-3806	653	16	a1	a1	NOUN
fnp-3806	653	17	and	and	CCONJ
fnp-3806	653	18	a2	a2	PROPN
fnp-3806	653	19	astrocyte	astrocyte	NOUN
fnp-3806	653	20	phenotypes	phenotype	NOUN
fnp-3806	653	21	have	have	AUX
fnp-3806	653	22	been	be	AUX
fnp-3806	653	23	proposed	propose	VERB
fnp-3806	653	24	depending	depend	VERB
fnp-3806	653	25	on	on	ADP
fnp-3806	653	26	their	their	PRON
fnp-3806	653	27	transcriptional	transcriptional	ADJ
fnp-3806	653	28	profiles	profile	NOUN
fnp-3806	653	29	:	:	PUNCT
fnp-3806	653	30	a1	a1	NOUN
fnp-3806	653	31	are	be	AUX
fnp-3806	653	32	neurotoxic	neurotoxic	ADJ
fnp-3806	653	33	and	and	CCONJ
fnp-3806	653	34	a2	a2	PROPN
fnp-3806	653	35	neuroprotective	neuroprotective	ADJ
fnp-3806	653	36	(	(	PUNCT
fnp-3806	653	37	738	738	NUM
fnp-3806	653	38	,	,	PUNCT
fnp-3806	653	39	802	802	NUM
fnp-3806	653	40	)	)	PUNCT
fnp-3806	653	41	.	.	PUNCT
fnp-3806	654	1	however	however	ADV
fnp-3806	654	2	,	,	PUNCT
fnp-3806	654	3	this	this	DET
fnp-3806	654	4	categorization	categorization	NOUN
fnp-3806	654	5	is	be	AUX
fnp-3806	654	6	difficult	difficult	ADJ
fnp-3806	654	7	to	to	PART
fnp-3806	654	8	apply	apply	VERB
fnp-3806	654	9	in	in	ADP
fnp-3806	654	10	the	the	DET
fnp-3806	654	11	context	context	NOUN
fnp-3806	654	12	of	of	ADP
fnp-3806	654	13	sad	sad	ADJ
fnp-3806	654	14	(	(	PUNCT
fnp-3806	654	15	801	801	NUM
fnp-3806	654	16	-	-	NUM
fnp-3806	654	17	803	803	NUM
fnp-3806	654	18	)	)	PUNCT
fnp-3806	654	19	.	.	PUNCT
fnp-3806	655	1	glucose	glucose	NOUN
fnp-3806	655	2	hypometabolism	hypometabolism	NOUN
fnp-3806	655	3	is	be	AUX
fnp-3806	655	4	a	a	DET
fnp-3806	655	5	characteristic	characteristic	ADJ
fnp-3806	655	6	metabolic	metabolic	NOUN
fnp-3806	655	7	feature	feature	NOUN
fnp-3806	655	8	associated	associate	VERB
fnp-3806	655	9	with	with	ADP
fnp-3806	655	10	cognitive	cognitive	ADJ
fnp-3806	655	11	impairment	impairment	NOUN
fnp-3806	655	12	in	in	ADP
fnp-3806	655	13	ad	ad	NOUN
fnp-3806	655	14	(	(	PUNCT
fnp-3806	655	15	804	804	NUM
fnp-3806	655	16	-	-	NUM
fnp-3806	655	17	807	807	NUM
fnp-3806	655	18	)	)	PUNCT
fnp-3806	655	19	.	.	PUNCT
fnp-3806	656	1	furthermore	furthermore	ADV
fnp-3806	656	2	,	,	PUNCT
fnp-3806	656	3	neurons	neuron	NOUN
fnp-3806	656	4	utilize	utilize	VERB
fnp-3806	656	5	lactate	lactate	NOUN
fnp-3806	656	6	as	as	ADP
fnp-3806	656	7	a	a	DET
fnp-3806	656	8	source	source	NOUN
fnp-3806	656	9	of	of	ADP
fnp-3806	656	10	energy	energy	NOUN
fnp-3806	656	11	,	,	PUNCT
fnp-3806	656	12	and	and	CCONJ
fnp-3806	656	13	astrocytes	astrocyte	NOUN
fnp-3806	656	14	are	be	AUX
fnp-3806	656	15	the	the	DET
fnp-3806	656	16	main	main	ADJ
fnp-3806	656	17	local	local	ADJ
fnp-3806	656	18	source	source	NOUN
fnp-3806	656	19	of	of	ADP
fnp-3806	656	20	neuronal	neuronal	ADJ
fnp-3806	656	21	lactate	lactate	NOUN
fnp-3806	656	22	(	(	PUNCT
fnp-3806	656	23	808	808	NUM
fnp-3806	656	24	-	-	SYM
fnp-3806	656	25	811	811	NUM
fnp-3806	656	26	)	)	PUNCT
fnp-3806	656	27	.	.	PUNCT
fnp-3806	657	1	lactate	lactate	NOUN
fnp-3806	657	2	levels	level	NOUN
fnp-3806	657	3	are	be	AUX
fnp-3806	657	4	reduced	reduce	VERB
fnp-3806	657	5	in	in	ADP
fnp-3806	657	6	the	the	DET
fnp-3806	657	7	brain	brain	NOUN
fnp-3806	657	8	of	of	ADP
fnp-3806	657	9	ad	ad	NOUN
fnp-3806	657	10	transgenic	transgenic	NOUN
fnp-3806	657	11	murine	murine	NOUN
fnp-3806	657	12	models	model	NOUN
fnp-3806	657	13	(	(	PUNCT
fnp-3806	657	14	812	812	NUM
fnp-3806	657	15	)	)	PUNCT
fnp-3806	657	16	.	.	PUNCT
fnp-3806	658	1	in	in	ADP
fnp-3806	658	2	the	the	DET
fnp-3806	658	3	brain	brain	NOUN
fnp-3806	658	4	,	,	PUNCT
fnp-3806	658	5	the	the	DET
fnp-3806	658	6	local	local	ADJ
fnp-3806	658	7	source	source	NOUN
fnp-3806	658	8	of	of	ADP
fnp-3806	658	9	ketone	ketone	NOUN
fnp-3806	658	10	bodies	body	NOUN
fnp-3806	658	11	results	result	VERB
fnp-3806	658	12	from	from	ADP
fnp-3806	658	13	fatty	fatty	NOUN
fnp-3806	658	14	acid	acid	NOUN
fnp-3806	658	15	oxidation	oxidation	NOUN
fnp-3806	658	16	in	in	ADP
fnp-3806	658	17	astrocytes	astrocyte	NOUN
fnp-3806	658	18	(	(	PUNCT
fnp-3806	658	19	813	813	NUM
fnp-3806	658	20	)	)	PUNCT
fnp-3806	658	21	.	.	PUNCT
fnp-3806	659	1	in	in	ADP
fnp-3806	659	2	addition	addition	NOUN
fnp-3806	659	3	,	,	PUNCT
fnp-3806	659	4	astrocytes	astrocyte	NOUN
fnp-3806	659	5	can	can	AUX
fnp-3806	659	6	produce	produce	VERB
fnp-3806	659	7	ketones	ketone	NOUN
fnp-3806	659	8	from	from	ADP
fnp-3806	659	9	amino	amino	ADJ
fnp-3806	659	10	acids	acid	NOUN
fnp-3806	659	11	(	(	PUNCT
fnp-3806	659	12	814	814	NUM
fnp-3806	659	13	)	)	PUNCT
fnp-3806	659	14	.	.	PUNCT
fnp-3806	660	1	considering	consider	VERB
fnp-3806	660	2	that	that	SCONJ
fnp-3806	660	3	about	about	ADV
fnp-3806	660	4	20	20	NUM
fnp-3806	660	5	%	%	NOUN
fnp-3806	660	6	of	of	ADP
fnp-3806	660	7	cerebral	cerebral	ADJ
fnp-3806	660	8	atp	atp	PROPN
fnp-3806	660	9	is	be	AUX
fnp-3806	660	10	generated	generate	VERB
fnp-3806	660	11	from	from	ADP
fnp-3806	660	12	fatty	fatty	ADJ
fnp-3806	660	13	acids	acid	NOUN
fnp-3806	660	14	(	(	PUNCT
fnp-3806	660	15	815	815	NUM
fnp-3806	660	16	)	)	PUNCT
fnp-3806	660	17	,	,	PUNCT
fnp-3806	660	18	it	it	PRON
fnp-3806	660	19	may	may	AUX
fnp-3806	660	20	be	be	AUX
fnp-3806	660	21	inferred	infer	VERB
fnp-3806	660	22	that	that	SCONJ
fnp-3806	660	23	impaired	impair	VERB
fnp-3806	660	24	energy	energy	NOUN
fnp-3806	660	25	metabolism	metabolism	NOUN
fnp-3806	660	26	in	in	ADP
fnp-3806	660	27	astrocytes	astrocyte	NOUN
fnp-3806	660	28	negatively	negatively	ADV
fnp-3806	660	29	impacts	impact	NOUN
fnp-3806	660	30	on	on	ADP
fnp-3806	660	31	neuronal	neuronal	ADJ
fnp-3806	660	32	energy	energy	NOUN
fnp-3806	660	33	metabolism	metabolism	NOUN
fnp-3806	660	34	,	,	PUNCT
fnp-3806	660	35	including	include	VERB
fnp-3806	660	36	maintenance	maintenance	NOUN
fnp-3806	660	37	of	of	ADP
fnp-3806	660	38	the	the	DET
fnp-3806	660	39	energy	energy	NOUN
fnp-3806	660	40	requirements	requirement	NOUN
fnp-3806	660	41	of	of	ADP
fnp-3806	660	42	the	the	DET
fnp-3806	660	43	synapses	synapsis	NOUN
fnp-3806	660	44	(	(	PUNCT
fnp-3806	660	45	803	803	NUM
fnp-3806	660	46	,	,	PUNCT
fnp-3806	660	47	816	816	NUM
fnp-3806	660	48	-	-	SYM
fnp-3806	660	49	818	818	NUM
fnp-3806	660	50	)	)	PUNCT
fnp-3806	660	51	.	.	PUNCT
fnp-3806	661	1	12b	12b	NOUN
fnp-3806	661	2	.	.	PUNCT
fnp-3806	662	1	microglia	microglia	ADJ
fnp-3806	662	2	microglial	microglial	ADJ
fnp-3806	662	3	cells	cell	NOUN
fnp-3806	662	4	are	be	AUX
fnp-3806	662	5	multifunctional	multifunctional	ADJ
fnp-3806	662	6	cells	cell	NOUN
fnp-3806	662	7	that	that	PRON
fnp-3806	662	8	respond	respond	VERB
fnp-3806	662	9	to	to	ADP
fnp-3806	662	10	different	different	ADJ
fnp-3806	662	11	stimuli	stimulus	NOUN
fnp-3806	662	12	leading	lead	VERB
fnp-3806	662	13	to	to	ADP
fnp-3806	662	14	either	either	CCONJ
fnp-3806	662	15	beneficial	beneficial	ADJ
fnp-3806	662	16	or	or	CCONJ
fnp-3806	662	17	harmful	harmful	ADJ
fnp-3806	662	18	effects	effect	NOUN
fnp-3806	662	19	depending	depend	VERB
fnp-3806	662	20	on	on	ADP
fnp-3806	662	21	the	the	DET
fnp-3806	662	22	production	production	NOUN
fnp-3806	662	23	of	of	ADP
fnp-3806	662	24	specific	specific	ADJ
fnp-3806	662	25	molecules	molecule	NOUN
fnp-3806	662	26	.	.	PUNCT
fnp-3806	663	1	several	several	ADJ
fnp-3806	663	2	studies	study	NOUN
fnp-3806	663	3	have	have	AUX
fnp-3806	663	4	dealt	deal	VERB
fnp-3806	663	5	with	with	ADP
fnp-3806	663	6	a	a	DET
fnp-3806	663	7	proposed	propose	VERB
fnp-3806	663	8	polarization	polarization	NOUN
fnp-3806	663	9	of	of	ADP
fnp-3806	663	10	microglia	microglia	NOUN
fnp-3806	663	11	into	into	ADP
fnp-3806	663	12	two	two	NUM
fnp-3806	663	13	types	type	NOUN
fnp-3806	663	14	.	.	PUNCT
fnp-3806	664	1	m1	m1	NOUN
fnp-3806	664	2	phenotype	phenotype	NOUN
fnp-3806	664	3	is	be	AUX
fnp-3806	664	4	stimulated	stimulate	VERB
fnp-3806	664	5	by	by	ADP
fnp-3806	664	6	interferon	interferon	ADJ
fnp-3806	664	7	-	-	PUNCT
fnp-3806	664	8	γ	γ	X
fnp-3806	664	9	(	(	PUNCT
fnp-3806	664	10	ifn	ifn	PROPN
fnp-3806	664	11	-	-	PUNCT
fnp-3806	664	12	γ	γ	NOUN
fnp-3806	664	13	)	)	PUNCT
fnp-3806	664	14	for	for	ADP
fnp-3806	664	15	the	the	DET
fnp-3806	664	16	expression	expression	NOUN
fnp-3806	664	17	of	of	ADP
fnp-3806	664	18	pro	pro	ADJ
fnp-3806	664	19	-	-	ADJ
fnp-3806	664	20	inflammatory	inflammatory	ADJ
fnp-3806	664	21	cytokines	cytokine	NOUN
fnp-3806	664	22	,	,	PUNCT
fnp-3806	664	23	and	and	CCONJ
fnp-3806	664	24	m2	m2	PROPN
fnp-3806	664	25	phenotype	phenotype	NOUN
fnp-3806	664	26	by	by	ADP
fnp-3806	664	27	il-4	il-4	NOUN
fnp-3806	664	28	/	/	SYM
fnp-3806	664	29	il-13	il-13	VERB
fnp-3806	664	30	for	for	ADP
fnp-3806	664	31	resolution	resolution	NOUN
fnp-3806	664	32	of	of	ADP
fnp-3806	664	33	inflammation	inflammation	NOUN
fnp-3806	664	34	and	and	CCONJ
fnp-3806	664	35	tissue	tissue	NOUN
fnp-3806	664	36	repair	repair	NOUN
fnp-3806	664	37	(	(	PUNCT
fnp-3806	664	38	819	819	NUM
fnp-3806	664	39	)	)	PUNCT
fnp-3806	664	40	.	.	PUNCT
fnp-3806	665	1	however	however	ADV
fnp-3806	665	2	,	,	PUNCT
fnp-3806	665	3	the	the	DET
fnp-3806	665	4	division	division	NOUN
fnp-3806	665	5	between	between	ADP
fnp-3806	665	6	m1	m1	PROPN
fnp-3806	665	7	and	and	CCONJ
fnp-3806	665	8	m2	m2	PROPN
fnp-3806	665	9	microglial	microglial	ADJ
fnp-3806	665	10	phenotypes	phenotype	NOUN
fnp-3806	665	11	with	with	ADP
fnp-3806	665	12	opposing	opposing	ADJ
fnp-3806	665	13	effects	effect	NOUN
fnp-3806	665	14	in	in	ADP
fnp-3806	665	15	pathological	pathological	ADJ
fnp-3806	665	16	conditions	condition	NOUN
fnp-3806	665	17	is	be	AUX
fnp-3806	665	18	probably	probably	ADV
fnp-3806	665	19	a	a	DET
fnp-3806	665	20	simplification	simplification	NOUN
fnp-3806	665	21	,	,	PUNCT
fnp-3806	665	22	as	as	SCONJ
fnp-3806	665	23	complex	complex	ADJ
fnp-3806	665	24	microglial	microglial	ADJ
fnp-3806	665	25	responses	response	NOUN
fnp-3806	665	26	occur	occur	VERB
fnp-3806	665	27	in	in	ADP
fnp-3806	665	28	the	the	DET
fnp-3806	665	29	same	same	ADJ
fnp-3806	665	30	setting	setting	NOUN
fnp-3806	665	31	,	,	PUNCT
fnp-3806	665	32	particularly	particularly	ADV
fnp-3806	665	33	in	in	ADP
fnp-3806	665	34	ad	ad	NOUN
fnp-3806	665	35	(	(	PUNCT
fnp-3806	665	36	820	820	NUM
fnp-3806	665	37	,	,	PUNCT
fnp-3806	665	38	821	821	NUM
fnp-3806	665	39	)	)	PUNCT
fnp-3806	665	40	.	.	PUNCT
fnp-3806	666	1	the	the	DET
fnp-3806	666	2	term	term	NOUN
fnp-3806	666	3	neuroinflammation	neuroinflammation	NOUN
fnp-3806	666	4	,	,	PUNCT
fnp-3806	666	5	although	although	SCONJ
fnp-3806	666	6	widely	widely	ADV
fnp-3806	666	7	used	use	VERB
fnp-3806	666	8	,	,	PUNCT
fnp-3806	666	9	sheds	shed	VERB
fnp-3806	666	10	little	little	ADJ
fnp-3806	666	11	light	light	NOUN
fnp-3806	666	12	on	on	ADP
fnp-3806	666	13	the	the	DET
fnp-3806	666	14	molecular	molecular	ADJ
fnp-3806	666	15	consequences	consequence	NOUN
fnp-3806	666	16	of	of	ADP
fnp-3806	666	17	microglial	microglial	ADJ
fnp-3806	666	18	(	(	PUNCT
fnp-3806	666	19	and	and	CCONJ
fnp-3806	666	20	astrocytic	astrocytic	ADJ
fnp-3806	666	21	)	)	PUNCT
fnp-3806	666	22	responses	response	NOUN
fnp-3806	666	23	in	in	ADP
fnp-3806	666	24	any	any	DET
fnp-3806	666	25	particular	particular	ADJ
fnp-3806	666	26	setting	setting	NOUN
fnp-3806	666	27	(	(	PUNCT
fnp-3806	666	28	822	822	NUM
fnp-3806	666	29	-	-	SYM
fnp-3806	666	30	824	824	NUM
fnp-3806	666	31	)	)	PUNCT
fnp-3806	666	32	.	.	PUNCT
fnp-3806	667	1	microglia	microglia	NOUN
fnp-3806	667	2	are	be	AUX
fnp-3806	667	3	modified	modify	VERB
fnp-3806	667	4	in	in	ADP
fnp-3806	667	5	aging	aging	NOUN
fnp-3806	667	6	and	and	CCONJ
fnp-3806	667	7	ad	ad	NOUN
fnp-3806	667	8	(	(	PUNCT
fnp-3806	667	9	825	825	NUM
fnp-3806	667	10	-	-	PUNCT
fnp-3806	667	11	828	828	NUM
fnp-3806	667	12	)	)	PUNCT
fnp-3806	667	13	.	.	PUNCT
fnp-3806	668	1	dystrophic	dystrophic	ADJ
fnp-3806	668	2	(	(	PUNCT
fnp-3806	668	3	senescent	senescent	ADJ
fnp-3806	668	4	)	)	PUNCT
fnp-3806	668	5	microglia	microglia	ADJ
fnp-3806	668	6	precede	precede	NOUN
fnp-3806	668	7	activated	activate	VERB
fnp-3806	668	8	microglia	microglia	NOUN
fnp-3806	668	9	in	in	ADP
fnp-3806	668	10	aging	age	VERB
fnp-3806	668	11	and	and	CCONJ
fnp-3806	668	12	sad	sad	ADJ
fnp-3806	668	13	(	(	PUNCT
fnp-3806	668	14	826	826	NUM
fnp-3806	668	15	)	)	PUNCT
fnp-3806	668	16	.	.	PUNCT
fnp-3806	669	1	increased	increase	VERB
fnp-3806	669	2	numbers	number	NOUN
fnp-3806	669	3	of	of	ADP
fnp-3806	669	4	activated	activate	VERB
fnp-3806	669	5	microglial	microglial	ADJ
fnp-3806	669	6	cells	cell	NOUN
fnp-3806	669	7	occur	occur	VERB
fnp-3806	669	8	in	in	ADP
fnp-3806	669	9	parallel	parallel	NOUN
fnp-3806	669	10	with	with	ADP
fnp-3806	669	11	the	the	DET
fnp-3806	669	12	production	production	NOUN
fnp-3806	669	13	of	of	ADP
fnp-3806	669	14	β	β	NOUN
fnp-3806	669	15	-	-	NOUN
fnp-3806	669	16	amyloid	amyloid	NOUN
fnp-3806	669	17	and	and	CCONJ
fnp-3806	669	18	tau	tau	PROPN
fnp-3806	669	19	pathology	pathology	NOUN
fnp-3806	669	20	(	(	PUNCT
fnp-3806	669	21	829	829	NUM
fnp-3806	669	22	)	)	PUNCT
fnp-3806	669	23	.	.	PUNCT
fnp-3806	670	1	microglial	microglial	ADJ
fnp-3806	670	2	cells	cell	NOUN
fnp-3806	670	3	are	be	AUX
fnp-3806	670	4	found	find	VERB
fnp-3806	670	5	associated	associate	VERB
fnp-3806	670	6	with	with	ADP
fnp-3806	670	7	sps	sps	PROPN
fnp-3806	670	8	in	in	ADP
fnp-3806	670	9	contact	contact	NOUN
fnp-3806	670	10	with	with	ADP
fnp-3806	670	11	dystrophic	dystrophic	ADJ
fnp-3806	670	12	neurites	neurite	NOUN
fnp-3806	670	13	and	and	CCONJ
fnp-3806	670	14	internal	internal	ADJ
fnp-3806	670	15	to	to	ADP
fnp-3806	670	16	reactive	reactive	ADJ
fnp-3806	670	17	astrocytes	astrocyte	NOUN
fnp-3806	670	18	(	(	PUNCT
fnp-3806	670	19	7	7	NUM
fnp-3806	670	20	)	)	PUNCT
fnp-3806	670	21	.	.	PUNCT
fnp-3806	671	1	diffuse	diffuse	PROPN
fnp-3806	671	2	microgliosis	microgliosis	PROPN
fnp-3806	671	3	involving	involve	VERB
fnp-3806	671	4	the	the	DET
fnp-3806	671	5	cerebral	cerebral	ADJ
fnp-3806	671	6	cortex	cortex	NOUN
fnp-3806	671	7	and	and	CCONJ
fnp-3806	671	8	subcortical	subcortical	ADJ
fnp-3806	671	9	white	white	ADJ
fnp-3806	671	10	matter	matter	NOUN
fnp-3806	671	11	occurs	occur	VERB
fnp-3806	671	12	as	as	ADV
fnp-3806	671	13	well	well	ADV
fnp-3806	671	14	.	.	PUNCT
fnp-3806	672	1	microglial	microglial	ADJ
fnp-3806	672	2	activation	activation	NOUN
fnp-3806	672	3	in	in	ADP
fnp-3806	672	4	ad	ad	NOUN
fnp-3806	672	5	is	be	AUX
fnp-3806	672	6	associated	associate	VERB
fnp-3806	672	7	with	with	ADP
fnp-3806	672	8	upregulation	upregulation	NOUN
fnp-3806	672	9	of	of	ADP
fnp-3806	672	10	a	a	DET
fnp-3806	672	11	large	large	ADJ
fnp-3806	672	12	number	number	NOUN
fnp-3806	672	13	of	of	ADP
fnp-3806	672	14	cytokines	cytokine	NOUN
fnp-3806	672	15	,	,	PUNCT
fnp-3806	672	16	chemokines	chemokine	NOUN
fnp-3806	672	17	,	,	PUNCT
fnp-3806	672	18	members	member	NOUN
fnp-3806	672	19	of	of	ADP
fnp-3806	672	20	the	the	DET
fnp-3806	672	21	complement	complement	NOUN
fnp-3806	672	22	system	system	NOUN
fnp-3806	672	23	,	,	PUNCT
fnp-3806	672	24	and	and	CCONJ
fnp-3806	672	25	other	other	ADJ
fnp-3806	672	26	mediators	mediator	NOUN
fnp-3806	672	27	of	of	ADP
fnp-3806	672	28	the	the	DET
fnp-3806	672	29	immune	immune	ADJ
fnp-3806	672	30	system	system	NOUN
fnp-3806	672	31	(	(	PUNCT
fnp-3806	672	32	736	736	NUM
fnp-3806	672	33	,	,	PUNCT
fnp-3806	672	34	830	830	NUM
fnp-3806	672	35	-	-	NUM
fnp-3806	672	36	837	837	NUM
fnp-3806	672	37	)	)	PUNCT
fnp-3806	672	38	.	.	PUNCT
fnp-3806	673	1	importantly	importantly	ADV
fnp-3806	673	2	,	,	PUNCT
fnp-3806	673	3	the	the	DET
fnp-3806	673	4	inflammatory	inflammatory	ADJ
fnp-3806	673	5	response	response	NOUN
fnp-3806	673	6	is	be	AUX
fnp-3806	673	7	not	not	PART
fnp-3806	673	8	homogeneous	homogeneous	ADJ
fnp-3806	673	9	but	but	CCONJ
fnp-3806	673	10	is	be	AUX
fnp-3806	673	11	largely	largely	ADV
fnp-3806	673	12	region	region	NOUN
fnp-3806	673	13	and	and	CCONJ
fnp-3806	673	14	stage	stage	NOUN
fnp-3806	673	15	dependent	dependent	ADJ
fnp-3806	673	16	(	(	PUNCT
fnp-3806	673	17	838	838	NUM
fnp-3806	673	18	)	)	PUNCT
fnp-3806	673	19	.	.	PUNCT
fnp-3806	674	1	inflammatory	inflammatory	ADJ
fnp-3806	674	2	responses	response	NOUN
fnp-3806	674	3	also	also	ADV
fnp-3806	674	4	occur	occur	VERB
fnp-3806	674	5	in	in	ADP
fnp-3806	674	6	transgenic	transgenic	NOUN
fnp-3806	674	7	mouse	mouse	NOUN
fnp-3806	674	8	models	model	NOUN
fnp-3806	674	9	of	of	ADP
fnp-3806	674	10	ad	ad	NOUN
fnp-3806	674	11	with	with	ADP
fnp-3806	674	12	specific	specific	ADJ
fnp-3806	674	13	region	region	NOUN
fnp-3806	674	14	and	and	CCONJ
fnp-3806	674	15	stage	stage	NOUN
fnp-3806	674	16	profiles	profile	NOUN
fnp-3806	674	17	.	.	PUNCT
fnp-3806	675	1	yet	yet	ADV
fnp-3806	675	2	,	,	PUNCT
fnp-3806	675	3	the	the	DET
fnp-3806	675	4	regulation	regulation	NOUN
fnp-3806	675	5	of	of	ADP
fnp-3806	675	6	different	different	ADJ
fnp-3806	675	7	components	component	NOUN
fnp-3806	675	8	of	of	ADP
fnp-3806	675	9	brain	brain	NOUN
fnp-3806	675	10	inflammation	inflammation	NOUN
fnp-3806	675	11	and	and	CCONJ
fnp-3806	675	12	the	the	DET
fnp-3806	675	13	immune	immune	ADJ
fnp-3806	675	14	system	system	NOUN
fnp-3806	675	15	differ	differ	VERB
fnp-3806	675	16	in	in	ADP
fnp-3806	675	17	transgenic	transgenic	NOUN
fnp-3806	675	18	mice	mouse	NOUN
fnp-3806	675	19	when	when	SCONJ
fnp-3806	675	20	compared	compare	VERB
fnp-3806	675	21	with	with	ADP
fnp-3806	675	22	sad	sad	ADJ
fnp-3806	675	23	(	(	PUNCT
fnp-3806	675	24	838	838	NUM
fnp-3806	675	25	,	,	PUNCT
fnp-3806	675	26	839	839	NUM
fnp-3806	675	27	)	)	PUNCT
fnp-3806	675	28	.	.	PUNCT
fnp-3806	676	1	this	this	PRON
fnp-3806	676	2	is	be	AUX
fnp-3806	676	3	an	an	DET
fnp-3806	676	4	important	important	ADJ
fnp-3806	676	5	point	point	NOUN
fnp-3806	676	6	,	,	PUNCT
fnp-3806	676	7	as	as	SCONJ
fnp-3806	676	8	inflammatory	inflammatory	ADJ
fnp-3806	676	9	responses	response	NOUN
fnp-3806	676	10	vary	vary	VERB
fnp-3806	676	11	in	in	ADP
fnp-3806	676	12	different	different	ADJ
fnp-3806	676	13	regions	region	NOUN
fnp-3806	676	14	with	with	ADP
fnp-3806	676	15	disease	disease	NOUN
fnp-3806	676	16	progression	progression	NOUN
fnp-3806	676	17	;	;	PUNCT
fnp-3806	676	18	protective	protective	ADJ
fnp-3806	676	19	and	and	CCONJ
fnp-3806	676	20	deleterious	deleterious	ADJ
fnp-3806	676	21	microglia	microglia	ADJ
fnp-3806	676	22	-	-	PUNCT
fnp-3806	676	23	associated	associate	VERB
fnp-3806	676	24	effects	effect	NOUN
fnp-3806	676	25	may	may	AUX
fnp-3806	676	26	occur	occur	VERB
fnp-3806	676	27	simultaneously	simultaneously	ADV
fnp-3806	676	28	in	in	ADP
fnp-3806	676	29	any	any	DET
fnp-3806	676	30	individual	individual	NOUN
fnp-3806	676	31	at	at	ADP
fnp-3806	676	32	any	any	DET
fnp-3806	676	33	stage	stage	NOUN
fnp-3806	676	34	of	of	ADP
fnp-3806	676	35	the	the	DET
fnp-3806	676	36	disease	disease	NOUN
fnp-3806	676	37	.	.	PUNCT
fnp-3806	677	1	another	another	DET
fnp-3806	677	2	relevant	relevant	ADJ
fnp-3806	677	3	point	point	NOUN
fnp-3806	677	4	is	be	AUX
fnp-3806	677	5	the	the	DET
fnp-3806	677	6	role	role	NOUN
fnp-3806	677	7	of	of	ADP
fnp-3806	677	8	lipids	lipid	NOUN
fnp-3806	677	9	in	in	ADP
fnp-3806	677	10	activated	activate	VERB
fnp-3806	677	11	microglia	microglia	NOUN
fnp-3806	677	12	;	;	PUNCT
fnp-3806	677	13	increased	increase	VERB
fnp-3806	677	14	expression	expression	NOUN
fnp-3806	677	15	of	of	ADP
fnp-3806	677	16	apoe	apoe	NOUN
fnp-3806	677	17	,	,	PUNCT
fnp-3806	677	18	triggering	trigger	VERB
fnp-3806	677	19	receptor	receptor	NOUN
fnp-3806	677	20	expressed	express	VERB
fnp-3806	677	21	on	on	ADP
fnp-3806	677	22	myeloid	myeloid	ADJ
fnp-3806	677	23	cells	cell	NOUN
fnp-3806	677	24	2	2	NUM
fnp-3806	677	25	(	(	PUNCT
fnp-3806	677	26	trem2	trem2	NOUN
fnp-3806	677	27	)	)	PUNCT
fnp-3806	677	28	,	,	PUNCT
fnp-3806	677	29	and	and	CCONJ
fnp-3806	677	30	lipoprotein	lipoprotein	ADJ
fnp-3806	677	31	lipase	lipase	NOUN
fnp-3806	677	32	(	(	PUNCT
fnp-3806	677	33	lp2	lp2	PROPN
fnp-3806	677	34	)	)	PUNCT
fnp-3806	677	35	,	,	PUNCT
fnp-3806	677	36	is	be	AUX
fnp-3806	677	37	found	find	VERB
fnp-3806	677	38	in	in	ADP
fnp-3806	677	39	activated	activate	VERB
fnp-3806	677	40	microglia	microglia	NOUN
fnp-3806	677	41	(	(	PUNCT
fnp-3806	677	42	840	840	NUM
fnp-3806	677	43	)	)	PUNCT
fnp-3806	677	44	.	.	PUNCT
fnp-3806	678	1	a	a	DET
fnp-3806	678	2	link	link	NOUN
fnp-3806	678	3	between	between	ADP
fnp-3806	678	4	β	β	NOUN
fnp-3806	678	5	-	-	NOUN
fnp-3806	678	6	amyloid	amyloid	NOUN
fnp-3806	678	7	and	and	CCONJ
fnp-3806	678	8	microglia	microglia	NOUN
fnp-3806	678	9	is	be	AUX
fnp-3806	678	10	well	well	ADV
fnp-3806	678	11	documented	document	VERB
fnp-3806	678	12	(	(	PUNCT
fnp-3806	678	13	829	829	NUM
fnp-3806	678	14	,	,	PUNCT
fnp-3806	678	15	841	841	NUM
fnp-3806	678	16	,	,	PUNCT
fnp-3806	678	17	842	842	NUM
fnp-3806	678	18	)	)	PUNCT
fnp-3806	678	19	.	.	PUNCT
fnp-3806	679	1	a	a	DET
fnp-3806	679	2	cell	cell	NOUN
fnp-3806	679	3	surface	surface	NOUN
fnp-3806	679	4	receptor	receptor	NOUN
fnp-3806	679	5	complex	complex	NOUN
fnp-3806	679	6	for	for	ADP
fnp-3806	679	7	fibrillary	fibrillary	ADJ
fnp-3806	679	8	-	-	PUNCT
fnp-3806	679	9	amyloid	amyloid	NOUN
fnp-3806	679	10	mediates	mediate	NOUN
fnp-3806	679	11	microglial	microglial	ADJ
fnp-3806	679	12	activation	activation	NOUN
fnp-3806	679	13	(	(	PUNCT
fnp-3806	679	14	843	843	NUM
fnp-3806	679	15	)	)	PUNCT
fnp-3806	679	16	.	.	PUNCT
fnp-3806	680	1	microglia	microglia	ADJ
fnp-3806	680	2	,	,	PUNCT
fnp-3806	680	3	in	in	ADP
fnp-3806	680	4	turn	turn	NOUN
fnp-3806	680	5	,	,	PUNCT
fnp-3806	680	6	mediates	mediate	VERB
fnp-3806	680	7	the	the	DET
fnp-3806	680	8	clearance	clearance	NOUN
fnp-3806	680	9	of	of	ADP
fnp-3806	680	10	soluble	soluble	ADJ
fnp-3806	680	11	aβ	aβ	NOUN
fnp-3806	680	12	through	through	ADP
fnp-3806	680	13	fluid	fluid	ADJ
fnp-3806	680	14	phase	phase	NOUN
fnp-3806	680	15	macropinocytosis	macropinocytosis	NOUN
fnp-3806	680	16	(	(	PUNCT
fnp-3806	680	17	844	844	NUM
fnp-3806	680	18	)	)	PUNCT
fnp-3806	680	19	.	.	PUNCT
fnp-3806	681	1	microglia	microglia	ADJ
fnp-3806	681	2	-	-	PUNCT
fnp-3806	681	3	mediated	mediate	VERB
fnp-3806	681	4	synapsis	synapsis	NOUN
fnp-3806	681	5	loss	loss	NOUN
fnp-3806	681	6	in	in	ADP
fnp-3806	681	7	ad	ad	NOUN
fnp-3806	681	8	is	be	AUX
fnp-3806	681	9	enhanced	enhance	VERB
fnp-3806	681	10	by	by	ADP
fnp-3806	681	11	fibrillar	fibrillar	ADJ
fnp-3806	681	12	aβ	aβ	NOUN
fnp-3806	681	13	and	and	CCONJ
fnp-3806	681	14	oligomeric	oligomeric	ADJ
fnp-3806	681	15	aβ	aβ	NOUN
fnp-3806	681	16	aggregation	aggregation	NOUN
fnp-3806	681	17	onto	onto	ADP
fnp-3806	681	18	neuronal	neuronal	ADJ
fnp-3806	681	19	post	post	ADJ
fnp-3806	681	20	-	-	ADJ
fnp-3806	681	21	synaptic	synaptic	ADJ
fnp-3806	681	22	terminals	terminal	NOUN
fnp-3806	681	23	,	,	PUNCT
fnp-3806	681	24	complement	complement	NOUN
fnp-3806	681	25	deposition	deposition	NOUN
fnp-3806	681	26	,	,	PUNCT
fnp-3806	681	27	c3	c3	PROPN
fnp-3806	681	28	receptor	receptor	NOUN
fnp-3806	681	29	(	(	PUNCT
fnp-3806	681	30	cd11b	cd11b	X
fnp-3806	681	31	/	/	SYM
fnp-3806	681	32	cd18	cd18	PROPN
fnp-3806	681	33	)	)	PUNCT
fnp-3806	681	34	activation	activation	NOUN
fnp-3806	681	35	,	,	PUNCT
fnp-3806	681	36	microglial	microglial	ADJ
fnp-3806	681	37	activation	activation	NOUN
fnp-3806	681	38	,	,	PUNCT
fnp-3806	681	39	and	and	CCONJ
fnp-3806	681	40	synapsis	synapsis	NOUN
fnp-3806	681	41	phagocytosis	phagocytosis	NOUN
fnp-3806	681	42	(	(	PUNCT
fnp-3806	681	43	821	821	NUM
fnp-3806	681	44	,	,	PUNCT
fnp-3806	681	45	845	845	NUM
fnp-3806	681	46	-	-	SYM
fnp-3806	681	47	849	849	NUM
fnp-3806	681	48	)	)	PUNCT
fnp-3806	681	49	.	.	PUNCT
fnp-3806	682	1	microglia	microglia	ADJ
fnp-3806	682	2	activation	activation	NOUN
fnp-3806	682	3	also	also	ADV
fnp-3806	682	4	correlates	correlate	VERB
fnp-3806	682	5	with	with	ADP
fnp-3806	682	6	tau	tau	PROPN
fnp-3806	682	7	pathology	pathology	PROPN
fnp-3806	682	8	and	and	CCONJ
fnp-3806	682	9	nft	nft	PROPN
fnp-3806	682	10	staging	staging	NOUN
fnp-3806	682	11	(	(	PUNCT
fnp-3806	682	12	829	829	NUM
fnp-3806	682	13	,	,	PUNCT
fnp-3806	682	14	850	850	NUM
fnp-3806	682	15	-	-	SYM
fnp-3806	682	16	852	852	NUM
fnp-3806	682	17	)	)	PUNCT
fnp-3806	682	18	.	.	PUNCT
fnp-3806	683	1	positron	positron	NOUN
fnp-3806	683	2	emission	emission	NOUN
fnp-3806	683	3	tomography	tomography	NOUN
fnp-3806	683	4	(	(	PUNCT
fnp-3806	683	5	pet)-based	pet)-based	ADJ
fnp-3806	683	6	studies	study	NOUN
fnp-3806	683	7	have	have	AUX
fnp-3806	683	8	also	also	ADV
fnp-3806	683	9	shown	show	VERB
fnp-3806	683	10	a	a	DET
fnp-3806	683	11	correlation	correlation	NOUN
fnp-3806	683	12	between	between	ADP
fnp-3806	683	13	tau	tau	PROPN
fnp-3806	683	14	pathology	pathology	NOUN
fnp-3806	683	15	progression	progression	NOUN
fnp-3806	683	16	and	and	CCONJ
fnp-3806	683	17	microglial	microglial	ADJ
fnp-3806	683	18	activation	activation	NOUN
fnp-3806	683	19	across	across	ADP
fnp-3806	683	20	braak	braak	PROPN
fnp-3806	683	21	stages	stage	NOUN
fnp-3806	683	22	(	(	PUNCT
fnp-3806	683	23	853	853	NUM
fnp-3806	683	24	,	,	PUNCT
fnp-3806	683	25	854	854	NUM
fnp-3806	683	26	)	)	PUNCT
fnp-3806	683	27	.	.	PUNCT
fnp-3806	684	1	abnormal	abnormal	ADJ
fnp-3806	684	2	tau	tau	PROPN
fnp-3806	684	3	at	at	ADP
fnp-3806	684	4	the	the	DET
fnp-3806	684	5	synapsis	synapsis	NOUN
fnp-3806	684	6	also	also	ADV
fnp-3806	684	7	favors	favor	VERB
fnp-3806	684	8	synapsis	synapsis	NOUN
fnp-3806	684	9	pruning	pruning	NOUN
fnp-3806	684	10	and	and	CCONJ
fnp-3806	684	11	elimination	elimination	NOUN
fnp-3806	684	12	by	by	ADP
fnp-3806	684	13	micoglial	micoglial	ADJ
fnp-3806	684	14	phagocytosis	phagocytosis	NOUN
fnp-3806	684	15	(	(	PUNCT
fnp-3806	684	16	855	855	NUM
fnp-3806	684	17	)	)	PUNCT
fnp-3806	684	18	.	.	PUNCT
fnp-3806	685	1	the	the	DET
fnp-3806	685	2	notion	notion	NOUN
fnp-3806	685	3	that	that	SCONJ
fnp-3806	685	4	two	two	NUM
fnp-3806	685	5	types	type	NOUN
fnp-3806	685	6	of	of	ADP
fnp-3806	685	7	microglial	microglial	ADJ
fnp-3806	685	8	cells	cell	NOUN
fnp-3806	685	9	,	,	PUNCT
fnp-3806	685	10	unrelated	unrelated	ADJ
fnp-3806	685	11	to	to	ADP
fnp-3806	685	12	the	the	DET
fnp-3806	685	13	proposed	propose	VERB
fnp-3806	685	14	m1	m1	PROPN
fnp-3806	685	15	and	and	CCONJ
fnp-3806	685	16	m2	m2	PROPN
fnp-3806	685	17	subtypes	subtype	NOUN
fnp-3806	685	18	,	,	PUNCT
fnp-3806	685	19	may	may	AUX
fnp-3806	685	20	play	play	VERB
fnp-3806	685	21	different	different	ADJ
fnp-3806	685	22	roles	role	NOUN
fnp-3806	685	23	in	in	ADP
fnp-3806	685	24	sad	sad	ADJ
fnp-3806	685	25	is	be	AUX
fnp-3806	685	26	supported	support	VERB
fnp-3806	685	27	by	by	ADP
fnp-3806	685	28	recent	recent	ADJ
fnp-3806	685	29	observations	observation	NOUN
fnp-3806	685	30	.	.	PUNCT
fnp-3806	686	1	using	use	VERB
fnp-3806	686	2	single	single	ADJ
fnp-3806	686	3	nuclei	nucleus	NOUN
fnp-3806	686	4	rna	rna	NOUN
fnp-3806	686	5	sequencing	sequence	VERB
fnp-3806	686	6	(	(	PUNCT
fnp-3806	686	7	snrnaseq	snrnaseq	NOUN
fnp-3806	686	8	)	)	PUNCT
fnp-3806	686	9	of	of	ADP
fnp-3806	686	10	isolated	isolate	VERB
fnp-3806	686	11	microglial	microglial	ADJ
fnp-3806	686	12	nuclei	nucleus	NOUN
fnp-3806	686	13	in	in	ADP
fnp-3806	686	14	sad	sad	ADJ
fnp-3806	686	15	brains	brain	NOUN
fnp-3806	686	16	,	,	PUNCT
fnp-3806	686	17	the	the	DET
fnp-3806	686	18	abundance	abundance	NOUN
fnp-3806	686	19	of	of	ADP
fnp-3806	686	20	phagocytic	phagocytic	ADJ
fnp-3806	686	21	/	/	SYM
fnp-3806	686	22	activated	activate	VERB
fnp-3806	686	23	named	name	VERB
fnp-3806	686	24	ad1	ad1	NOUN
fnp-3806	686	25	-	-	PUNCT
fnp-3806	686	26	microglia	microglia	NOUN
fnp-3806	686	27	correlates	correlate	VERB
fnp-3806	686	28	with	with	ADP
fnp-3806	686	29	tissue	tissue	NOUN
fnp-3806	686	30	β	β	NOUN
fnp-3806	686	31	-	-	NOUN
fnp-3806	686	32	amyloid	amyloid	NOUN
fnp-3806	686	33	load	load	NOUN
fnp-3806	686	34	and	and	CCONJ
fnp-3806	686	35	localizes	localize	VERB
fnp-3806	686	36	with	with	ADP
fnp-3806	686	37	β	β	NOUN
fnp-3806	686	38	-	-	ADJ
fnp-3806	686	39	amyloid	amyloid	ADJ
fnp-3806	686	40	plaques	plaque	NOUN
fnp-3806	686	41	;	;	PUNCT
fnp-3806	686	42	ad2	ad2	PROPN
fnp-3806	686	43	-	-	PUNCT
fnp-3806	686	44	microglia	microglia	NOUN
fnp-3806	686	45	are	be	AUX
fnp-3806	686	46	more	more	ADV
fnp-3806	686	47	abundant	abundant	ADJ
fnp-3806	686	48	in	in	ADP
fnp-3806	686	49	association	association	NOUN
fnp-3806	686	50	with	with	ADP
fnp-3806	686	51	tau	tau	PROPN
fnp-3806	686	52	pathology	pathology	NOUN
fnp-3806	686	53	(	(	PUNCT
fnp-3806	686	54	856	856	NUM
fnp-3806	686	55	)	)	PUNCT
fnp-3806	686	56	.	.	PUNCT
fnp-3806	687	1	microglial	microglial	ADJ
fnp-3806	687	2	and	and	CCONJ
fnp-3806	687	3	altered	alter	VERB
fnp-3806	687	4	expression	expression	NOUN
fnp-3806	687	5	of	of	ADP
fnp-3806	687	6	inflammatory	inflammatory	ADJ
fnp-3806	687	7	markers	marker	NOUN
fnp-3806	687	8	is	be	AUX
fnp-3806	687	9	observed	observe	VERB
fnp-3806	687	10	in	in	ADP
fnp-3806	687	11	children	child	NOUN
fnp-3806	687	12	with	with	ADP
fnp-3806	687	13	down	down	ADP
fnp-3806	687	14	syndrome	syndrome	NOUN
fnp-3806	687	15	,	,	PUNCT
fnp-3806	687	16	and	and	CCONJ
fnp-3806	687	17	it	it	PRON
fnp-3806	687	18	is	be	AUX
fnp-3806	687	19	modified	modify	VERB
fnp-3806	687	20	in	in	ADP
fnp-3806	687	21	parallel	parallel	NOUN
fnp-3806	687	22	with	with	ADP
fnp-3806	687	23	the	the	DET
fnp-3806	687	24	appearance	appearance	NOUN
fnp-3806	687	25	of	of	ADP
fnp-3806	687	26	tau	tau	PROPN
fnp-3806	687	27	and	and	CCONJ
fnp-3806	687	28	β	β	NOUN
fnp-3806	687	29	-	-	ADJ
fnp-3806	687	30	amyloid	amyloid	ADJ
fnp-3806	687	31	pathology	pathology	NOUN
fnp-3806	687	32	and	and	CCONJ
fnp-3806	687	33	through	through	ADP
fnp-3806	687	34	disease	disease	NOUN
fnp-3806	687	35	progression	progression	NOUN
fnp-3806	687	36	.	.	PUNCT
fnp-3806	688	1	microglial	microglial	ADJ
fnp-3806	688	2	responses	response	NOUN
fnp-3806	688	3	in	in	ADP
fnp-3806	688	4	down	down	ADP
fnp-3806	688	5	syndrome	syndrome	NOUN
fnp-3806	688	6	with	with	ADP
fnp-3806	688	7	ad	ad	NOUN
fnp-3806	688	8	pathology	pathology	NOUN
fnp-3806	688	9	differ	differ	VERB
fnp-3806	688	10	from	from	ADP
fnp-3806	688	11	those	those	PRON
fnp-3806	688	12	of	of	ADP
fnp-3806	688	13	sad	sad	ADJ
fnp-3806	688	14	(	(	PUNCT
fnp-3806	688	15	857	857	NUM
fnp-3806	688	16	-	-	NUM
fnp-3806	688	17	859	859	NUM
fnp-3806	688	18	)	)	PUNCT
fnp-3806	688	19	.	.	PUNCT
fnp-3806	689	1	the	the	DET
fnp-3806	689	2	profile	profile	NOUN
fnp-3806	689	3	of	of	ADP
fnp-3806	689	4	brain	brain	NOUN
fnp-3806	689	5	inflammatory	inflammatory	ADJ
fnp-3806	689	6	responses	response	NOUN
fnp-3806	689	7	also	also	ADV
fnp-3806	689	8	differs	differ	VERB
fnp-3806	689	9	in	in	ADP
fnp-3806	689	10	human	human	ADJ
fnp-3806	689	11	cases	case	NOUN
fnp-3806	689	12	with	with	ADP
fnp-3806	689	13	ad	ad	NOUN
fnp-3806	689	14	-	-	PUNCT
fnp-3806	689	15	resilient	resilient	ADJ
fnp-3806	689	16	pathology	pathology	NOUN
fnp-3806	689	17	;	;	PUNCT
fnp-3806	689	18	levels	level	NOUN
fnp-3806	689	19	of	of	ADP
fnp-3806	689	20	trophic	trophic	ADJ
fnp-3806	689	21	factors	factor	NOUN
fnp-3806	689	22	are	be	AUX
fnp-3806	689	23	increased	increase	VERB
fnp-3806	689	24	,	,	PUNCT
fnp-3806	689	25	whereas	whereas	SCONJ
fnp-3806	689	26	expression	expression	NOUN
fnp-3806	689	27	levels	level	NOUN
fnp-3806	689	28	of	of	ADP
fnp-3806	689	29	chemokines	chemokine	NOUN
fnp-3806	689	30	are	be	AUX
fnp-3806	689	31	decreased	decrease	VERB
fnp-3806	689	32	(	(	PUNCT
fnp-3806	689	33	860	860	NUM
fnp-3806	689	34	)	)	PUNCT
fnp-3806	689	35	.	.	PUNCT
fnp-3806	690	1	the	the	DET
fnp-3806	690	2	inflammasome	inflammasome	NOUN
fnp-3806	690	3	is	be	AUX
fnp-3806	690	4	a	a	DET
fnp-3806	690	5	multi	multi	ADJ
fnp-3806	690	6	-	-	ADJ
fnp-3806	690	7	protein	protein	ADJ
fnp-3806	690	8	complex	complex	NOUN
fnp-3806	690	9	containing	contain	VERB
fnp-3806	690	10	a	a	DET
fnp-3806	690	11	member	member	NOUN
fnp-3806	690	12	of	of	ADP
fnp-3806	690	13	the	the	DET
fnp-3806	690	14	nod	nod	NOUN
fnp-3806	690	15	-	-	PUNCT
fnp-3806	690	16	like	like	ADJ
fnp-3806	690	17	family	family	NOUN
fnp-3806	690	18	,	,	PUNCT
fnp-3806	690	19	such	such	ADJ
fnp-3806	690	20	as	as	ADP
fnp-3806	690	21	pyrin	pyrin	NOUN
fnp-3806	690	22	-	-	PUNCT
fnp-3806	690	23	domain	domain	NOUN
fnp-3806	690	24	containing	contain	VERB
fnp-3806	690	25	3	3	NUM
fnp-3806	690	26	(	(	PUNCT
fnp-3806	690	27	nlrp3r	nlrp3r	PROPN
fnp-3806	690	28	)	)	PUNCT
fnp-3806	690	29	that	that	PRON
fnp-3806	690	30	interacts	interact	VERB
fnp-3806	690	31	with	with	ADP
fnp-3806	690	32	the	the	DET
fnp-3806	690	33	inflammasome	inflammasome	NOUN
fnp-3806	690	34	-	-	PUNCT
fnp-3806	690	35	adaptor	adaptor	NOUN
fnp-3806	690	36	protein	protein	NOUN
fnp-3806	690	37	asc	asc	PROPN
fnp-3806	690	38	.	.	PUNCT
fnp-3806	691	1	the	the	DET
fnp-3806	691	2	immune	immune	ADJ
fnp-3806	691	3	response	response	NOUN
fnp-3806	691	4	elicited	elicit	VERB
fnp-3806	691	5	by	by	ADP
fnp-3806	691	6	β	β	NOUN
fnp-3806	691	7	-	-	NOUN
fnp-3806	691	8	amyloid	amyloid	NOUN
fnp-3806	691	9	functions	function	NOUN
fnp-3806	691	10	through	through	ADP
fnp-3806	691	11	complex	complex	ADJ
fnp-3806	691	12	crosstalk	crosstalk	NOUN
fnp-3806	691	13	between	between	ADP
fnp-3806	691	14	the	the	DET
fnp-3806	691	15	toll	toll	NOUN
fnp-3806	691	16	-	-	PUNCT
fnp-3806	691	17	like	like	ADJ
fnp-3806	691	18	receptor	receptor	NOUN
fnp-3806	691	19	4	4	NUM
fnp-3806	691	20	(	(	PUNCT
fnp-3806	691	21	tlr4	tlr4	NOUN
fnp-3806	691	22	)	)	PUNCT
fnp-3806	691	23	,	,	PUNCT
fnp-3806	691	24	complement	complement	NOUN
fnp-3806	691	25	,	,	PUNCT
fnp-3806	691	26	and	and	CCONJ
fnp-3806	691	27	inflammasome	inflammasome	VERB
fnp-3806	691	28	signaling	signal	VERB
fnp-3806	691	29	pathways	pathway	NOUN
fnp-3806	691	30	(	(	PUNCT
fnp-3806	691	31	861	861	NUM
fnp-3806	691	32	)	)	PUNCT
fnp-3806	691	33	.	.	PUNCT
fnp-3806	692	1	the	the	DET
fnp-3806	692	2	activation	activation	NOUN
fnp-3806	692	3	of	of	ADP
fnp-3806	692	4	the	the	DET
fnp-3806	692	5	inflammasome	inflammasome	NOUN
fnp-3806	692	6	in	in	ADP
fnp-3806	692	7	microglia	microglia	ADJ
fnp-3806	692	8	triggers	trigger	NOUN
fnp-3806	692	9	a	a	DET
fnp-3806	692	10	cascade	cascade	NOUN
fnp-3806	692	11	that	that	PRON
fnp-3806	692	12	involves	involve	VERB
fnp-3806	692	13	caspase	caspase	NOUN
fnp-3806	692	14	1	1	NUM
fnp-3806	692	15	,	,	PUNCT
fnp-3806	692	16	and	and	CCONJ
fnp-3806	692	17	maturation	maturation	NOUN
fnp-3806	692	18	of	of	ADP
fnp-3806	692	19	several	several	ADJ
fnp-3806	692	20	cytokines	cytokine	NOUN
fnp-3806	692	21	including	include	VERB
fnp-3806	692	22	il-1β	il-1β	PROPN
fnp-3806	692	23	and	and	CCONJ
fnp-3806	692	24	il-18	il-18	PRON
fnp-3806	692	25	.	.	PUNCT
fnp-3806	693	1	the	the	DET
fnp-3806	693	2	inflammasome	inflammasome	NOUN
fnp-3806	693	3	in	in	ADP
fnp-3806	693	4	microglia	microglia	ADJ
fnp-3806	693	5	participates	participate	NOUN
fnp-3806	693	6	in	in	ADP
fnp-3806	693	7	the	the	DET
fnp-3806	693	8	nucleation	nucleation	NOUN
fnp-3806	693	9	of	of	ADP
fnp-3806	693	10	β	β	NOUN
fnp-3806	693	11	-	-	ADJ
fnp-3806	693	12	amyloid	amyloid	ADJ
fnp-3806	693	13	plaques	plaque	NOUN
fnp-3806	693	14	and	and	CCONJ
fnp-3806	693	15	enhances	enhance	VERB
fnp-3806	693	16	tau	tau	PROPN
fnp-3806	693	17	pathology	pathology	NOUN
fnp-3806	693	18	(	(	PUNCT
fnp-3806	693	19	862	862	NUM
fnp-3806	693	20	,	,	PUNCT
fnp-3806	693	21	863	863	NUM
fnp-3806	693	22	)	)	PUNCT
fnp-3806	693	23	.	.	PUNCT
fnp-3806	694	1	aβ	aβ	NOUN
fnp-3806	694	2	aggregates	aggregate	NOUN
fnp-3806	694	3	,	,	PUNCT
fnp-3806	694	4	and	and	CCONJ
fnp-3806	694	5	soluble	soluble	ADJ
fnp-3806	694	6	aβ	aβ	NOUN
fnp-3806	694	7	oligomers	oligomer	NOUN
fnp-3806	694	8	and	and	CCONJ
fnp-3806	694	9	protofibrils	protofibril	NOUN
fnp-3806	694	10	,	,	PUNCT
fnp-3806	694	11	activate	activate	VERB
fnp-3806	694	12	the	the	DET
fnp-3806	694	13	nlrp3	nlrp3	ADJ
fnp-3806	694	14	inflammasome	inflammasome	NOUN
fnp-3806	694	15	(	(	PUNCT
fnp-3806	694	16	864	864	NUM
fnp-3806	694	17	-	-	SYM
fnp-3806	694	18	866	866	NUM
fnp-3806	694	19	)	)	PUNCT
fnp-3806	694	20	.	.	PUNCT
fnp-3806	695	1	conversely	conversely	ADV
fnp-3806	695	2	,	,	PUNCT
fnp-3806	695	3	activation	activation	NOUN
fnp-3806	695	4	of	of	ADP
fnp-3806	695	5	nlrp3	nlrp3	NOUN
fnp-3806	695	6	-	-	PUNCT
fnp-3806	695	7	asc	asc	PROPN
fnp-3806	695	8	inflammasome	inflammasome	NOUN
fnp-3806	695	9	aggravates	aggravate	VERB
fnp-3806	695	10	amyloid	amyloid	NOUN
fnp-3806	695	11	pathology	pathology	NOUN
fnp-3806	695	12	(	(	PUNCT
fnp-3806	695	13	867	867	NUM
fnp-3806	695	14	)	)	PUNCT
fnp-3806	695	15	.	.	PUNCT
fnp-3806	696	1	aggregated	aggregate	VERB
fnp-3806	696	2	tau	tau	PROPN
fnp-3806	696	3	also	also	ADV
fnp-3806	696	4	activates	activate	VERB
fnp-3806	696	5	nlrp3	nlrp3	PROPN
fnp-3806	696	6	/	/	SYM
fnp-3806	696	7	asc	asc	PROPN
fnp-3806	696	8	and	and	CCONJ
fnp-3806	696	9	exacerbates	exacerbate	VERB
fnp-3806	696	10	tau	tau	PROPN
fnp-3806	696	11	pathology	pathology	NOUN
fnp-3806	696	12	(	(	PUNCT
fnp-3806	696	13	868	868	NUM
fnp-3806	696	14	)	)	PUNCT
fnp-3806	696	15	.	.	PUNCT
fnp-3806	697	1	loss	loss	NOUN
fnp-3806	697	2	of	of	ADP
fnp-3806	697	3	nlrp3	nlrp3	NOUN
fnp-3806	697	4	inflammasome	inflammasome	NOUN
fnp-3806	697	5	function	function	NOUN
fnp-3806	697	6	reduces	reduce	VERB
fnp-3806	697	7	tau	tau	PROPN
fnp-3806	697	8	hyperphosphorylation	hyperphosphorylation	NOUN
fnp-3806	697	9	and	and	CCONJ
fnp-3806	697	10	aggregation	aggregation	NOUN
fnp-3806	697	11	by	by	ADP
fnp-3806	697	12	regulating	regulate	VERB
fnp-3806	697	13	tau	tau	PROPN
fnp-3806	697	14	kinases	kinase	NOUN
fnp-3806	697	15	and	and	CCONJ
fnp-3806	697	16	phosphatases	phosphatase	NOUN
fnp-3806	697	17	.	.	PUNCT
fnp-3806	698	1	conversely	conversely	ADV
fnp-3806	698	2	,	,	PUNCT
fnp-3806	698	3	tau	tau	PROPN
fnp-3806	698	4	activates	activate	VERB
fnp-3806	698	5	the	the	DET
fnp-3806	698	6	nlrp3	nlrp3	NOUN
fnp-3806	698	7	inflammasome	inflammasome	NOUN
fnp-3806	698	8	.	.	PUNCT
fnp-3806	699	1	moreover	moreover	ADV
fnp-3806	699	2	,	,	PUNCT
fnp-3806	699	3	the	the	DET
fnp-3806	699	4	intracerebral	intracerebral	ADJ
fnp-3806	699	5	injection	injection	NOUN
fnp-3806	699	6	of	of	ADP
fnp-3806	699	7	fibrillar	fibrillar	ADJ
fnp-3806	699	8	β	β	NOUN
fnp-3806	699	9	-	-	PUNCT
fnp-3806	699	10	containing	contain	VERB
fnp-3806	699	11	brain	brain	NOUN
fnp-3806	699	12	homogenates	homogenate	NOUN
fnp-3806	699	13	has	have	AUX
fnp-3806	699	14	been	be	AUX
fnp-3806	699	15	shown	show	VERB
fnp-3806	699	16	to	to	PART
fnp-3806	699	17	induce	induce	VERB
fnp-3806	699	18	tau	tau	PROPN
fnp-3806	699	19	pathology	pathology	NOUN
fnp-3806	699	20	in	in	ADP
fnp-3806	699	21	an	an	DET
fnp-3806	699	22	nlrp3	nlrp3	NOUN
fnp-3806	699	23	-	-	PUNCT
fnp-3806	699	24	dependent	dependent	ADJ
fnp-3806	699	25	manner	manner	NOUN
fnp-3806	699	26	(	(	PUNCT
fnp-3806	699	27	869	869	NUM
fnp-3806	699	28	)	)	PUNCT
fnp-3806	699	29	.	.	PUNCT
fnp-3806	700	1	microglial	microglial	ADJ
fnp-3806	700	2	and	and	CCONJ
fnp-3806	700	3	inflammatory	inflammatory	ADJ
fnp-3806	700	4	responses	response	NOUN
fnp-3806	700	5	are	be	AUX
fnp-3806	700	6	dependent	dependent	ADJ
fnp-3806	700	7	on	on	ADP
fnp-3806	700	8	genetic	genetic	ADJ
fnp-3806	700	9	factors	factor	NOUN
fnp-3806	700	10	in	in	ADP
fnp-3806	700	11	sad	sad	ADJ
fnp-3806	700	12	(	(	PUNCT
fnp-3806	700	13	280	280	NUM
fnp-3806	700	14	,	,	PUNCT
fnp-3806	700	15	870	870	NUM
fnp-3806	700	16	-	-	SYM
fnp-3806	700	17	872	872	NUM
fnp-3806	700	18	)	)	PUNCT
fnp-3806	700	19	.	.	PUNCT
fnp-3806	701	1	apoe	apoe	ADJ
fnp-3806	701	2	status	status	NOUN
fnp-3806	701	3	is	be	AUX
fnp-3806	701	4	a	a	DET
fnp-3806	701	5	modifier	modifier	NOUN
fnp-3806	701	6	of	of	ADP
fnp-3806	701	7	the	the	DET
fnp-3806	701	8	inflammatory	inflammatory	ADJ
fnp-3806	701	9	response	response	NOUN
fnp-3806	701	10	(	(	PUNCT
fnp-3806	701	11	873	873	NUM
fnp-3806	701	12	,	,	PUNCT
fnp-3806	701	13	874	874	NUM
fnp-3806	701	14	)	)	PUNCT
fnp-3806	701	15	.	.	PUNCT
fnp-3806	702	1	cd33	cd33	PROPN
fnp-3806	702	2	,	,	PUNCT
fnp-3806	702	3	trem2	trem2	NOUN
fnp-3806	702	4	,	,	PUNCT
fnp-3806	702	5	and	and	CCONJ
fnp-3806	702	6	other	other	ADJ
fnp-3806	702	7	genes	gene	NOUN
fnp-3806	702	8	linked	link	VERB
fnp-3806	702	9	with	with	ADP
fnp-3806	702	10	inflammation	inflammation	NOUN
fnp-3806	702	11	are	be	AUX
fnp-3806	702	12	expressed	express	VERB
fnp-3806	702	13	in	in	ADP
fnp-3806	702	14	microglia	microglia	NOUN
fnp-3806	702	15	(	(	PUNCT
fnp-3806	702	16	871	871	NUM
fnp-3806	702	17	,	,	PUNCT
fnp-3806	702	18	875	875	NUM
fnp-3806	702	19	,	,	PUNCT
fnp-3806	702	20	876	876	NUM
fnp-3806	702	21	)	)	PUNCT
fnp-3806	702	22	.	.	PUNCT
fnp-3806	703	1	carriers	carrier	NOUN
fnp-3806	703	2	of	of	ADP
fnp-3806	703	3	ad	ad	NOUN
fnp-3806	703	4	-	-	PUNCT
fnp-3806	703	5	associated	associate	VERB
fnp-3806	703	6	risk	risk	NOUN
fnp-3806	703	7	variants	variant	NOUN
fnp-3806	703	8	in	in	ADP
fnp-3806	703	9	trem2	trem2	NOUN
fnp-3806	703	10	show	show	VERB
fnp-3806	703	11	a	a	DET
fnp-3806	703	12	reduction	reduction	NOUN
fnp-3806	703	13	in	in	ADP
fnp-3806	703	14	plaque	plaque	NOUN
fnp-3806	703	15	-	-	PUNCT
fnp-3806	703	16	associated	associate	VERB
fnp-3806	703	17	microglia	microglia	NOUN
fnp-3806	703	18	,	,	PUNCT
fnp-3806	703	19	and	and	CCONJ
fnp-3806	703	20	an	an	DET
fnp-3806	703	21	increase	increase	NOUN
fnp-3806	703	22	in	in	ADP
fnp-3806	703	23	dystrophic	dystrophic	ADJ
fnp-3806	703	24	neurites	neurite	NOUN
fnp-3806	703	25	and	and	CCONJ
fnp-3806	703	26	overall	overall	ADJ
fnp-3806	703	27	pathological	pathological	ADJ
fnp-3806	703	28	tau	tau	NOUN
fnp-3806	703	29	compared	compare	VERB
fnp-3806	703	30	with	with	ADP
fnp-3806	703	31	ageand	ageand	NOUN
fnp-3806	703	32	disease	disease	NOUN
fnp-3806	703	33	stage	stage	NOUN
fnp-3806	703	34	-	-	PUNCT
fnp-3806	703	35	matched	match	VERB
fnp-3806	703	36	sad	sad	ADJ
fnp-3806	703	37	patients	patient	NOUN
fnp-3806	703	38	without	without	ADP
fnp-3806	703	39	trem2	trem2	NOUN
fnp-3806	703	40	risk	risk	NOUN
fnp-3806	703	41	variants	variant	NOUN
fnp-3806	703	42	(	(	PUNCT
fnp-3806	703	43	877	877	NUM
fnp-3806	703	44	)	)	PUNCT
fnp-3806	703	45	.	.	PUNCT
fnp-3806	704	1	another	another	DET
fnp-3806	704	2	study	study	NOUN
fnp-3806	704	3	shows	show	VERB
fnp-3806	704	4	that	that	SCONJ
fnp-3806	704	5	trem+	trem+	NOUN
fnp-3806	704	6	control	control	NOUN
fnp-3806	704	7	cases	case	NOUN
fnp-3806	704	8	have	have	VERB
fnp-3806	704	9	no	no	DET
fnp-3806	704	10	pathological	pathological	ADJ
fnp-3806	704	11	hallmarks	hallmark	NOUN
fnp-3806	704	12	of	of	ADP
fnp-3806	704	13	sad	sad	ADJ
fnp-3806	704	14	,	,	PUNCT
fnp-3806	704	15	whereas	whereas	SCONJ
fnp-3806	704	16	trem2	trem2	NOUN
fnp-3806	704	17	+	+	SYM
fnp-3806	704	18	sad	sad	ADJ
fnp-3806	704	19	cases	case	NOUN
fnp-3806	704	20	show	show	VERB
fnp-3806	704	21	amoeboid	amoeboid	ADJ
fnp-3806	704	22	microglia	microglia	NOUN
fnp-3806	704	23	and	and	CCONJ
fnp-3806	704	24	upregulation	upregulation	NOUN
fnp-3806	704	25	of	of	ADP
fnp-3806	704	26	inflammatory	inflammatory	ADJ
fnp-3806	704	27	markers	marker	NOUN
fnp-3806	704	28	when	when	SCONJ
fnp-3806	704	29	compared	compare	VERB
fnp-3806	704	30	with	with	ADP
fnp-3806	704	31	trem2	trem2	NOUN
fnp-3806	704	32	+	+	SYM
fnp-3806	704	33	controls	control	NOUN
fnp-3806	704	34	and	and	CCONJ
fnp-3806	704	35	trem2sad	trem2sad	NUM
fnp-3806	704	36	cases	case	NOUN
fnp-3806	704	37	.	.	PUNCT
fnp-3806	705	1	these	these	DET
fnp-3806	705	2	findings	finding	NOUN
fnp-3806	705	3	suggest	suggest	VERB
fnp-3806	705	4	that	that	SCONJ
fnp-3806	705	5	trem2	trem2	NOUN
fnp-3806	705	6	influences	influence	NOUN
fnp-3806	705	7	,	,	PUNCT
fnp-3806	705	8	but	but	CCONJ
fnp-3806	705	9	does	do	AUX
fnp-3806	705	10	not	not	PART
fnp-3806	705	11	trigger	trigger	VERB
fnp-3806	705	12	,	,	PUNCT
fnp-3806	705	13	the	the	DET
fnp-3806	705	14	microglial	microglial	ADJ
fnp-3806	705	15	responses	response	NOUN
fnp-3806	705	16	in	in	ADP
fnp-3806	705	17	sad	sad	ADJ
fnp-3806	705	18	(	(	PUNCT
fnp-3806	705	19	878	878	NUM
fnp-3806	705	20	)	)	PUNCT
fnp-3806	705	21	.	.	PUNCT
fnp-3806	706	1	12c	12c	NUM
fnp-3806	706	2	.	.	PUNCT
fnp-3806	706	3	oligodendrocytes	oligodendrocyte	VERB
fnp-3806	706	4	myelin	myelin	ADJ
fnp-3806	706	5	generation	generation	NOUN
fnp-3806	706	6	and	and	CCONJ
fnp-3806	706	7	maintenance	maintenance	NOUN
fnp-3806	706	8	,	,	PUNCT
fnp-3806	706	9	and	and	CCONJ
fnp-3806	706	10	axonal	axonal	ADJ
fnp-3806	706	11	nurture	nurture	NOUN
fnp-3806	706	12	in	in	ADP
fnp-3806	706	13	the	the	DET
fnp-3806	706	14	cns	cns	NOUN
fnp-3806	706	15	,	,	PUNCT
fnp-3806	706	16	are	be	AUX
fnp-3806	706	17	carried	carry	VERB
fnp-3806	706	18	by	by	ADP
fnp-3806	706	19	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	706	20	.	.	PUNCT
fnp-3806	707	1	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	707	2	may	may	AUX
fnp-3806	707	3	contain	contain	VERB
fnp-3806	707	4	abnormal	abnormal	ADJ
fnp-3806	707	5	protein	protein	NOUN
fnp-3806	707	6	deposits	deposit	NOUN
fnp-3806	707	7	in	in	ADP
fnp-3806	707	8	various	various	ADJ
fnp-3806	707	9	neurodegenerative	neurodegenerative	ADJ
fnp-3806	707	10	diseases	disease	NOUN
fnp-3806	707	11	with	with	ADP
fnp-3806	707	12	abnormal	abnormal	ADJ
fnp-3806	707	13	protein	protein	NOUN
fnp-3806	707	14	aggregates	aggregate	NOUN
fnp-3806	707	15	.	.	PUNCT
fnp-3806	708	1	yet	yet	ADV
fnp-3806	708	2	alterations	alteration	NOUN
fnp-3806	708	3	in	in	ADP
fnp-3806	708	4	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	708	5	may	may	AUX
fnp-3806	708	6	occur	occur	VERB
fnp-3806	708	7	without	without	ADP
fnp-3806	708	8	accompanying	accompany	VERB
fnp-3806	708	9	abnormal	abnormal	ADJ
fnp-3806	708	10	deposits	deposit	NOUN
fnp-3806	708	11	.	.	PUNCT
fnp-3806	709	1	oligodendrogliopathy	oligodendrogliopathy	ADJ
fnp-3806	709	2	is	be	AUX
fnp-3806	709	3	used	use	VERB
fnp-3806	709	4	to	to	PART
fnp-3806	709	5	stress	stress	VERB
fnp-3806	709	6	the	the	DET
fnp-3806	709	7	role	role	NOUN
fnp-3806	709	8	of	of	ADP
fnp-3806	709	9	altered	altered	ADJ
fnp-3806	709	10	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	709	11	in	in	ADP
fnp-3806	709	12	the	the	DET
fnp-3806	709	13	pathogenesis	pathogenesis	NOUN
fnp-3806	709	14	of	of	ADP
fnp-3806	709	15	certain	certain	ADJ
fnp-3806	709	16	neurological	neurological	ADJ
fnp-3806	709	17	diseases	disease	NOUN
fnp-3806	709	18	with	with	ADP
fnp-3806	709	19	or	or	CCONJ
fnp-3806	709	20	without	without	ADP
fnp-3806	709	21	abnormal	abnormal	ADJ
fnp-3806	709	22	oligodendroglial	oligodendroglial	ADJ
fnp-3806	709	23	deposits	deposit	NOUN
fnp-3806	709	24	(	(	PUNCT
fnp-3806	709	25	879	879	NUM
fnp-3806	709	26	)	)	PUNCT
fnp-3806	709	27	.	.	PUNCT
fnp-3806	710	1	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	710	2	suffer	suffer	VERB
fnp-3806	710	3	a	a	DET
fnp-3806	710	4	functional	functional	ADJ
fnp-3806	710	5	decline	decline	NOUN
fnp-3806	710	6	in	in	ADP
fnp-3806	710	7	aging	aging	NOUN
fnp-3806	710	8	and	and	CCONJ
fnp-3806	710	9	ad	ad	NOUN
fnp-3806	710	10	as	as	SCONJ
fnp-3806	710	11	revealed	reveal	VERB
fnp-3806	710	12	by	by	ADP
fnp-3806	710	13	combined	combined	ADJ
fnp-3806	710	14	morphological	morphological	ADJ
fnp-3806	710	15	,	,	PUNCT
fnp-3806	710	16	biochemical	biochemical	ADJ
fnp-3806	710	17	,	,	PUNCT
fnp-3806	710	18	and	and	CCONJ
fnp-3806	710	19	neuroradiological	neuroradiological	ADJ
fnp-3806	710	20	methods	method	NOUN
fnp-3806	710	21	.	.	PUNCT
fnp-3806	711	1	neuroimaging	neuroimaging	ADJ
fnp-3806	711	2	and	and	CCONJ
fnp-3806	711	3	neuropathological	neuropathological	ADJ
fnp-3806	711	4	studies	study	NOUN
fnp-3806	711	5	have	have	AUX
fnp-3806	711	6	shown	show	VERB
fnp-3806	711	7	reduced	reduce	VERB
fnp-3806	711	8	white	white	ADJ
fnp-3806	711	9	matter	matter	NOUN
fnp-3806	711	10	(	(	PUNCT
fnp-3806	711	11	wm	wm	NOUN
fnp-3806	711	12	)	)	PUNCT
fnp-3806	711	13	volume	volume	NOUN
fnp-3806	711	14	,	,	PUNCT
fnp-3806	711	15	wm	wm	PROPN
fnp-3806	711	16	lesions	lesion	NOUN
fnp-3806	711	17	,	,	PUNCT
fnp-3806	711	18	and	and	CCONJ
fnp-3806	711	19	altered	alter	VERB
fnp-3806	711	20	wm	wm	PROPN
fnp-3806	711	21	integrity	integrity	NOUN
fnp-3806	711	22	and	and	CCONJ
fnp-3806	711	23	cortical	cortical	ADJ
fnp-3806	711	24	disconnection	disconnection	NOUN
fnp-3806	711	25	in	in	ADP
fnp-3806	711	26	aging	age	VERB
fnp-3806	711	27	human	human	ADJ
fnp-3806	711	28	brain	brain	NOUN
fnp-3806	711	29	(	(	PUNCT
fnp-3806	711	30	880	880	NUM
fnp-3806	711	31	-	-	SYM
fnp-3806	711	32	884	884	NUM
fnp-3806	711	33	)	)	PUNCT
fnp-3806	711	34	.	.	PUNCT
fnp-3806	712	1	wm	wm	PROPN
fnp-3806	712	2	changes	change	NOUN
fnp-3806	712	3	are	be	AUX
fnp-3806	712	4	associated	associate	VERB
fnp-3806	712	5	with	with	ADP
fnp-3806	712	6	disruption	disruption	NOUN
fnp-3806	712	7	of	of	ADP
fnp-3806	712	8	myelin	myelin	NOUN
fnp-3806	712	9	and	and	CCONJ
fnp-3806	712	10	axons	axon	NOUN
fnp-3806	712	11	(	(	PUNCT
fnp-3806	712	12	885	885	NUM
fnp-3806	712	13	,	,	PUNCT
fnp-3806	712	14	886	886	NUM
fnp-3806	712	15	)	)	PUNCT
fnp-3806	712	16	.	.	PUNCT
fnp-3806	713	1	alterations	alteration	NOUN
fnp-3806	713	2	in	in	ADP
fnp-3806	713	3	the	the	DET
fnp-3806	713	4	number	number	NOUN
fnp-3806	713	5	of	of	ADP
fnp-3806	713	6	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	713	7	and	and	CCONJ
fnp-3806	713	8	oligodendroglial	oligodendroglial	ADJ
fnp-3806	713	9	precursor	precursor	NOUN
fnp-3806	713	10	cells	cell	NOUN
fnp-3806	713	11	(	(	PUNCT
fnp-3806	713	12	opcs	opcs	PROPN
fnp-3806	713	13	/	/	SYM
fnp-3806	713	14	ng2	ng2	ADV
fnp-3806	713	15	-	-	PUNCT
fnp-3806	713	16	positive	positive	ADJ
fnp-3806	713	17	cells	cell	NOUN
fnp-3806	713	18	)	)	PUNCT
fnp-3806	713	19	have	have	AUX
fnp-3806	713	20	been	be	AUX
fnp-3806	713	21	reported	report	VERB
fnp-3806	713	22	in	in	ADP
fnp-3806	713	23	aged	aged	ADJ
fnp-3806	713	24	primates	primate	NOUN
fnp-3806	713	25	and	and	CCONJ
fnp-3806	713	26	rodents	rodent	NOUN
fnp-3806	713	27	(	(	PUNCT
fnp-3806	713	28	887	887	NUM
fnp-3806	713	29	)	)	PUNCT
fnp-3806	713	30	.	.	PUNCT
fnp-3806	714	1	neuroimaging	neuroimage	VERB
fnp-3806	714	2	studies	study	NOUN
fnp-3806	714	3	show	show	VERB
fnp-3806	714	4	reduced	reduce	VERB
fnp-3806	714	5	wm	wm	PROPN
fnp-3806	714	6	size	size	NOUN
fnp-3806	714	7	,	,	PUNCT
fnp-3806	714	8	wm	wm	PROPN
fnp-3806	714	9	hyper	hyper	NOUN
fnp-3806	714	10	-	-	NOUN
fnp-3806	714	11	lucencies	lucencie	NOUN
fnp-3806	714	12	,	,	PUNCT
fnp-3806	714	13	and	and	CCONJ
fnp-3806	714	14	myelin	myelin	NOUN
fnp-3806	714	15	and	and	CCONJ
fnp-3806	714	16	axon	axon	ADJ
fnp-3806	714	17	damages	damage	NOUN
fnp-3806	714	18	in	in	ADP
fnp-3806	714	19	patients	patient	NOUN
fnp-3806	714	20	with	with	ADP
fnp-3806	714	21	mci	mci	PROPN
fnp-3806	714	22	and	and	CCONJ
fnp-3806	714	23	dementia	dementia	NOUN
fnp-3806	714	24	of	of	ADP
fnp-3806	714	25	alzheimer	alzheimer	PROPN
fnp-3806	714	26	’s	’s	PART
fnp-3806	714	27	type	type	NOUN
fnp-3806	714	28	(	(	PUNCT
fnp-3806	714	29	883	883	NUM
fnp-3806	714	30	,	,	PUNCT
fnp-3806	714	31	888	888	NUM
fnp-3806	714	32	-	-	SYM
fnp-3806	714	33	896	896	NUM
fnp-3806	714	34	)	)	PUNCT
fnp-3806	714	35	.	.	PUNCT
fnp-3806	715	1	wm	wm	PROPN
fnp-3806	715	2	atrophy	atrophy	NOUN
fnp-3806	715	3	,	,	PUNCT
fnp-3806	715	4	decreased	decrease	VERB
fnp-3806	715	5	myelin	myelin	ADJ
fnp-3806	715	6	density	density	NOUN
fnp-3806	715	7	,	,	PUNCT
fnp-3806	715	8	and	and	CCONJ
fnp-3806	715	9	demyelination	demyelination	NOUN
fnp-3806	715	10	are	be	AUX
fnp-3806	715	11	also	also	ADV
fnp-3806	715	12	observed	observe	VERB
fnp-3806	715	13	in	in	ADP
fnp-3806	715	14	post	post	ADJ
fnp-3806	715	15	-	-	ADJ
fnp-3806	715	16	mortem	mortem	ADJ
fnp-3806	715	17	neuropathological	neuropathological	ADJ
fnp-3806	715	18	studies	study	NOUN
fnp-3806	715	19	(	(	PUNCT
fnp-3806	715	20	881	881	NUM
fnp-3806	715	21	,	,	PUNCT
fnp-3806	715	22	896	896	NUM
fnp-3806	715	23	,	,	PUNCT
fnp-3806	715	24	897	897	NUM
fnp-3806	715	25	)	)	PUNCT
fnp-3806	715	26	.	.	PUNCT
fnp-3806	716	1	breakdown	breakdown	NOUN
fnp-3806	716	2	of	of	ADP
fnp-3806	716	3	wm	wm	PROPN
fnp-3806	716	4	integrity	integrity	NOUN
fnp-3806	716	5	is	be	AUX
fnp-3806	716	6	considered	consider	VERB
fnp-3806	716	7	a	a	DET
fnp-3806	716	8	contributor	contributor	NOUN
fnp-3806	716	9	to	to	ADP
fnp-3806	716	10	the	the	DET
fnp-3806	716	11	loss	loss	NOUN
fnp-3806	716	12	of	of	ADP
fnp-3806	716	13	neuronal	neuronal	ADJ
fnp-3806	716	14	tract	tract	NOUN
fnp-3806	716	15	connectivity	connectivity	NOUN
fnp-3806	716	16	in	in	ADP
fnp-3806	716	17	aging	age	VERB
fnp-3806	716	18	and	and	CCONJ
fnp-3806	716	19	sad	sad	ADJ
fnp-3806	716	20	(	(	PUNCT
fnp-3806	716	21	898	898	NUM
fnp-3806	716	22	,	,	PUNCT
fnp-3806	716	23	899	899	NUM
fnp-3806	716	24	)	)	PUNCT
fnp-3806	716	25	.	.	PUNCT
fnp-3806	717	1	recent	recent	ADJ
fnp-3806	717	2	neuropathological	neuropathological	ADJ
fnp-3806	717	3	studies	study	NOUN
fnp-3806	717	4	have	have	AUX
fnp-3806	717	5	shown	show	VERB
fnp-3806	717	6	preservation	preservation	NOUN
fnp-3806	717	7	of	of	ADP
fnp-3806	717	8	mbp	mbp	PROPN
fnp-3806	717	9	,	,	PUNCT
fnp-3806	717	10	plp1	plp1	PROPN
fnp-3806	717	11	,	,	PUNCT
fnp-3806	717	12	cnp	cnp	PROPN
fnp-3806	717	13	,	,	PUNCT
fnp-3806	717	14	mag	mag	ADJ
fnp-3806	717	15	,	,	PUNCT
fnp-3806	717	16	mal	mal	ADJ
fnp-3806	717	17	,	,	PUNCT
fnp-3806	717	18	mog	mog	NOUN
fnp-3806	717	19	,	,	PUNCT
fnp-3806	717	20	and	and	CCONJ
fnp-3806	717	21	mobp	mobp	NOUN
fnp-3806	717	22	mrna	mrna	PROPN
fnp-3806	717	23	expression	expression	NOUN
fnp-3806	717	24	levels	level	NOUN
fnp-3806	717	25	in	in	ADP
fnp-3806	717	26	the	the	DET
fnp-3806	717	27	wm	wm	PROPN
fnp-3806	717	28	of	of	ADP
fnp-3806	717	29	the	the	DET
fnp-3806	717	30	frontal	frontal	ADJ
fnp-3806	717	31	cortex	cortex	NOUN
fnp-3806	717	32	at	at	ADP
fnp-3806	717	33	nft	nft	PROPN
fnp-3806	717	34	stages	stage	NOUN
fnp-3806	717	35	i	i	PROPN
fnp-3806	717	36	-	-	PUNCT
fnp-3806	717	37	ii/0	ii/0	NOUN
fnp-3806	717	38	-	-	PUNCT
fnp-3806	717	39	a	a	PRON
fnp-3806	717	40	when	when	SCONJ
fnp-3806	717	41	compared	compare	VERB
fnp-3806	717	42	with	with	ADP
fnp-3806	717	43	ma	ma	PROPN
fnp-3806	717	44	individuals	individual	NOUN
fnp-3806	717	45	without	without	ADP
fnp-3806	717	46	nft	nft	PROPN
fnp-3806	717	47	pathology	pathology	PROPN
fnp-3806	717	48	,	,	PUNCT
fnp-3806	717	49	but	but	CCONJ
fnp-3806	717	50	a	a	DET
fnp-3806	717	51	significant	significant	ADJ
fnp-3806	717	52	decrease	decrease	NOUN
fnp-3806	717	53	at	at	ADP
fnp-3806	717	54	stages	stage	NOUN
fnp-3806	717	55	iii	iii	NOUN
fnp-3806	717	56	-	-	ADJ
fnp-3806	717	57	iv/0	iv/0	NOUN
fnp-3806	717	58	-	-	PUNCT
fnp-3806	717	59	c.	c.	NOUN
fnp-3806	717	60	this	this	PRON
fnp-3806	717	61	is	be	AUX
fnp-3806	717	62	accompanied	accompany	VERB
fnp-3806	717	63	by	by	ADP
fnp-3806	717	64	reduced	reduced	ADJ
fnp-3806	717	65	expression	expression	NOUN
fnp-3806	717	66	of	of	ADP
fnp-3806	717	67	ng2	ng2	NOUN
fnp-3806	717	68	and	and	CCONJ
fnp-3806	717	69	pdgfra	pdgfra	NOUN
fnp-3806	717	70	(	(	PUNCT
fnp-3806	717	71	platelet	platelet	NOUN
fnp-3806	717	72	-	-	PUNCT
fnp-3806	717	73	derived	derive	VERB
fnp-3806	717	74	growth	growth	NOUN
fnp-3806	717	75	factor	factor	NOUN
fnp-3806	717	76	receptor	receptor	NOUN
fnp-3806	717	77	a	a	PRON
fnp-3806	717	78	)	)	PUNCT
fnp-3806	717	79	mrna	mrna	PROPN
fnp-3806	717	80	,	,	PUNCT
fnp-3806	717	81	reduced	reduce	VERB
fnp-3806	717	82	numbers	number	NOUN
fnp-3806	717	83	of	of	ADP
fnp-3806	717	84	ng2-	ng2-	NUM
fnp-3806	717	85	,	,	PUNCT
fnp-3806	717	86	olig2-	olig2-	ADP
fnp-3806	717	87	,	,	PUNCT
fnp-3806	717	88	and	and	CCONJ
fnp-3806	717	89	hdac2	hdac2	NOUN
fnp-3806	717	90	(	(	PUNCT
fnp-3806	717	91	histone	histone	NOUN
fnp-3806	717	92	deacetylase	deacetylase	VERB
fnp-3806	717	93	2)-immunoreactive	2)-immunoreactive	NUM
fnp-3806	717	94	cells	cell	NOUN
fnp-3806	717	95	,	,	PUNCT
fnp-3806	717	96	and	and	CCONJ
fnp-3806	717	97	reduced	reduce	VERB
fnp-3806	717	98	glucose	glucose	NOUN
fnp-3806	717	99	transporter	transporter	NOUN
fnp-3806	717	100	immunoreactivity	immunoreactivity	NOUN
fnp-3806	717	101	at	at	ADP
fnp-3806	717	102	stages	stage	NOUN
fnp-3806	717	103	iii	iii	NOUN
fnp-3806	717	104	-	-	ADJ
fnp-3806	717	105	iv/0	iv/0	NOUN
fnp-3806	717	106	-	-	PUNCT
fnp-3806	717	107	c.	c.	NOUN
fnp-3806	717	108	curiously	curiously	ADV
fnp-3806	717	109	,	,	PUNCT
fnp-3806	717	110	partial	partial	ADJ
fnp-3806	717	111	recovery	recovery	NOUN
fnp-3806	717	112	of	of	ADP
fnp-3806	717	113	some	some	PRON
fnp-3806	717	114	of	of	ADP
fnp-3806	717	115	these	these	DET
fnp-3806	717	116	markers	marker	NOUN
fnp-3806	717	117	occurs	occur	VERB
fnp-3806	717	118	at	at	ADP
fnp-3806	717	119	stages	stage	NOUN
fnp-3806	717	120	v	v	ADP
fnp-3806	717	121	-	-	PUNCT
fnp-3806	717	122	vi	vi	NOUN
fnp-3806	717	123	/	/	SYM
fnp-3806	717	124	b	b	NOUN
fnp-3806	717	125	-	-	PUNCT
fnp-3806	717	126	c.	c.	NOUN
fnp-3806	717	127	these	these	DET
fnp-3806	717	128	changes	change	NOUN
fnp-3806	717	129	show	show	VERB
fnp-3806	717	130	that	that	SCONJ
fnp-3806	717	131	myelin	myelin	NOUN
fnp-3806	717	132	loss	loss	NOUN
fnp-3806	717	133	is	be	AUX
fnp-3806	717	134	accompanied	accompany	VERB
fnp-3806	717	135	by	by	ADP
fnp-3806	717	136	reduced	reduced	ADJ
fnp-3806	717	137	transcription	transcription	NOUN
fnp-3806	717	138	of	of	ADP
fnp-3806	717	139	myelin	myelin	NOUN
fnp-3806	717	140	-	-	PUNCT
fnp-3806	717	141	related	relate	VERB
fnp-3806	717	142	proteins	protein	NOUN
fnp-3806	717	143	in	in	ADP
fnp-3806	717	144	the	the	DET
fnp-3806	717	145	wm	wm	PROPN
fnp-3806	717	146	of	of	ADP
fnp-3806	717	147	the	the	DET
fnp-3806	717	148	frontal	frontal	ADJ
fnp-3806	717	149	cortex	cortex	NOUN
fnp-3806	717	150	at	at	ADP
fnp-3806	717	151	middle	middle	ADJ
fnp-3806	717	152	-	-	PUNCT
fnp-3806	717	153	stages	stage	NOUN
fnp-3806	717	154	of	of	ADP
fnp-3806	717	155	ad	ad	NOUN
fnp-3806	717	156	(	(	PUNCT
fnp-3806	717	157	342	342	NUM
fnp-3806	717	158	)	)	PUNCT
fnp-3806	717	159	.	.	PUNCT
fnp-3806	718	1	early	early	ADJ
fnp-3806	718	2	myelin	myelin	NOUN
fnp-3806	718	3	loss	loss	NOUN
fnp-3806	718	4	,	,	PUNCT
fnp-3806	718	5	decreased	decrease	VERB
fnp-3806	718	6	numbers	number	NOUN
fnp-3806	718	7	of	of	ADP
fnp-3806	718	8	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	718	9	,	,	PUNCT
fnp-3806	718	10	and	and	CCONJ
fnp-3806	718	11	region	region	NOUN
fnp-3806	718	12	-	-	PUNCT
fnp-3806	718	13	specific	specific	ADJ
fnp-3806	718	14	alterations	alteration	NOUN
fnp-3806	718	15	,	,	PUNCT
fnp-3806	718	16	followed	follow	VERB
fnp-3806	718	17	by	by	ADP
fnp-3806	718	18	partial	partial	ADJ
fnp-3806	718	19	reparative	reparative	ADJ
fnp-3806	718	20	responses	response	NOUN
fnp-3806	718	21	,	,	PUNCT
fnp-3806	718	22	also	also	ADV
fnp-3806	718	23	occur	occur	VERB
fnp-3806	718	24	in	in	ADP
fnp-3806	718	25	transgenic	transgenic	NOUN
fnp-3806	718	26	mouse	mouse	NOUN
fnp-3806	718	27	models	model	NOUN
fnp-3806	718	28	of	of	ADP
fnp-3806	718	29	ad	ad	NOUN
fnp-3806	718	30	(	(	PUNCT
fnp-3806	718	31	900	900	NUM
fnp-3806	718	32	-	-	NUM
fnp-3806	718	33	903	903	NUM
fnp-3806	718	34	)	)	PUNCT
fnp-3806	718	35	.	.	PUNCT
fnp-3806	719	1	13	13	NUM
fnp-3806	719	2	.	.	PUNCT
fnp-3806	720	1	the	the	DET
fnp-3806	720	2	neurovascular	neurovascular	ADJ
fnp-3806	720	3	system	system	NOUN
fnp-3806	720	4	in	in	ADP
fnp-3806	720	5	ad	ad	NOUN
fnp-3806	720	6	the	the	DET
fnp-3806	720	7	first	first	ADJ
fnp-3806	720	8	highlighting	highlighting	NOUN
fnp-3806	720	9	of	of	ADP
fnp-3806	720	10	the	the	DET
fnp-3806	720	11	role	role	NOUN
fnp-3806	720	12	of	of	ADP
fnp-3806	720	13	vascular	vascular	ADJ
fnp-3806	720	14	pathology	pathology	NOUN
fnp-3806	720	15	in	in	ADP
fnp-3806	720	16	ad	ad	NOUN
fnp-3806	720	17	was	be	AUX
fnp-3806	720	18	in	in	ADP
fnp-3806	720	19	1989	1989	NUM
fnp-3806	720	20	(	(	PUNCT
fnp-3806	720	21	904	904	NUM
fnp-3806	720	22	)	)	PUNCT
fnp-3806	720	23	.	.	PUNCT
fnp-3806	721	1	the	the	DET
fnp-3806	721	2	“	"	PUNCT
fnp-3806	721	3	vascular	vascular	ADJ
fnp-3806	721	4	hypothesis	hypothesis	NOUN
fnp-3806	721	5	”	"	PUNCT
fnp-3806	721	6	of	of	ADP
fnp-3806	721	7	sad	sad	ADJ
fnp-3806	721	8	has	have	AUX
fnp-3806	721	9	been	be	AUX
fnp-3806	721	10	supported	support	VERB
fnp-3806	721	11	more	more	ADV
fnp-3806	721	12	recently	recently	ADV
fnp-3806	721	13	(	(	PUNCT
fnp-3806	721	14	905	905	NUM
fnp-3806	721	15	-	-	PUNCT
fnp-3806	721	16	908	908	NUM
fnp-3806	721	17	)	)	PUNCT
fnp-3806	721	18	.	.	PUNCT
fnp-3806	722	1	interestingly	interestingly	ADV
fnp-3806	722	2	,	,	PUNCT
fnp-3806	722	3	denervation	denervation	NOUN
fnp-3806	722	4	probably	probably	ADV
fnp-3806	722	5	due	due	ADP
fnp-3806	722	6	to	to	ADP
fnp-3806	722	7	the	the	DET
fnp-3806	722	8	loss	loss	NOUN
fnp-3806	722	9	of	of	ADP
fnp-3806	722	10	inputs	input	NOUN
fnp-3806	722	11	from	from	ADP
fnp-3806	722	12	the	the	DET
fnp-3806	722	13	locus	locus	ADJ
fnp-3806	722	14	coeruleus	coeruleus	NOUN
fnp-3806	722	15	and	and	CCONJ
fnp-3806	722	16	basal	basal	ADJ
fnp-3806	722	17	forebrain	forebrain	NOUN
fnp-3806	722	18	was	be	AUX
fnp-3806	722	19	initially	initially	ADV
fnp-3806	722	20	considered	consider	VERB
fnp-3806	722	21	a	a	DET
fnp-3806	722	22	key	key	ADJ
fnp-3806	722	23	factor	factor	NOUN
fnp-3806	722	24	(	(	PUNCT
fnp-3806	722	25	909	909	NUM
fnp-3806	722	26	)	)	PUNCT
fnp-3806	722	27	;	;	PUNCT
fnp-3806	722	28	altered	alter	VERB
fnp-3806	722	29	innervation	innervation	NOUN
fnp-3806	722	30	of	of	ADP
fnp-3806	722	31	the	the	DET
fnp-3806	722	32	cerebral	cerebral	ADJ
fnp-3806	722	33	blood	blood	NOUN
fnp-3806	722	34	vessels	vessel	NOUN
fnp-3806	722	35	linked	link	VERB
fnp-3806	722	36	to	to	ADP
fnp-3806	722	37	cholinergic	cholinergic	ADJ
fnp-3806	722	38	deficiency	deficiency	NOUN
fnp-3806	722	39	is	be	AUX
fnp-3806	722	40	still	still	ADV
fnp-3806	722	41	postulated	postulate	VERB
fnp-3806	722	42	as	as	ADP
fnp-3806	722	43	contributing	contribute	VERB
fnp-3806	722	44	to	to	ADP
fnp-3806	722	45	cerebral	cerebral	ADJ
fnp-3806	722	46	blood	blood	NOUN
fnp-3806	722	47	flow	flow	NOUN
fnp-3806	722	48	(	(	PUNCT
fnp-3806	722	49	cbf	cbf	PROPN
fnp-3806	722	50	)	)	PUNCT
fnp-3806	722	51	reduction	reduction	NOUN
fnp-3806	722	52	(	(	PUNCT
fnp-3806	722	53	910	910	NUM
fnp-3806	722	54	,	,	PUNCT
fnp-3806	722	55	911	911	NUM
fnp-3806	722	56	)	)	PUNCT
fnp-3806	722	57	.	.	PUNCT
fnp-3806	723	1	there	there	PRON
fnp-3806	723	2	are	be	VERB
fnp-3806	723	3	hundreds	hundred	NOUN
fnp-3806	723	4	of	of	ADP
fnp-3806	723	5	papers	paper	NOUN
fnp-3806	723	6	dealing	deal	VERB
fnp-3806	723	7	with	with	ADP
fnp-3806	723	8	β	β	X
fnp-3806	723	9	-	-	NOUN
fnp-3806	723	10	amyloid	amyloid	ADJ
fnp-3806	723	11	angiopathy	angiopathy	NOUN
fnp-3806	723	12	and	and	CCONJ
fnp-3806	723	13	its	its	PRON
fnp-3806	723	14	effects	effect	NOUN
fnp-3806	723	15	on	on	ADP
fnp-3806	723	16	neurovascular	neurovascular	ADJ
fnp-3806	723	17	function	function	NOUN
fnp-3806	723	18	,	,	PUNCT
fnp-3806	723	19	as	as	ADV
fnp-3806	723	20	well	well	ADV
fnp-3806	723	21	as	as	ADP
fnp-3806	723	22	the	the	DET
fnp-3806	723	23	role	role	NOUN
fnp-3806	723	24	of	of	ADP
fnp-3806	723	25	lipid	lipid	ADJ
fnp-3806	723	26	transporters	transporter	NOUN
fnp-3806	723	27	and	and	CCONJ
fnp-3806	723	28	vascular	vascular	ADJ
fnp-3806	723	29	receptors	receptor	NOUN
fnp-3806	723	30	in	in	ADP
fnp-3806	723	31	the	the	DET
fnp-3806	723	32	clearing	clearing	NOUN
fnp-3806	723	33	of	of	ADP
fnp-3806	723	34	β	β	NOUN
fnp-3806	723	35	-	-	NOUN
fnp-3806	723	36	amyloid	amyloid	NOUN
fnp-3806	723	37	in	in	ADP
fnp-3806	723	38	the	the	DET
fnp-3806	723	39	cerebral	cerebral	ADJ
fnp-3806	723	40	blood	blood	NOUN
fnp-3806	723	41	vessels	vessel	NOUN
fnp-3806	723	42	(	(	PUNCT
fnp-3806	723	43	912	912	NUM
fnp-3806	723	44	-	-	SYM
fnp-3806	723	45	923	923	NUM
fnp-3806	723	46	)	)	PUNCT
fnp-3806	723	47	.	.	PUNCT
fnp-3806	724	1	yet	yet	ADV
fnp-3806	724	2	,	,	PUNCT
fnp-3806	724	3	there	there	PRON
fnp-3806	724	4	is	be	VERB
fnp-3806	724	5	also	also	ADV
fnp-3806	724	6	overwhelming	overwhelming	ADJ
fnp-3806	724	7	evidence	evidence	NOUN
fnp-3806	724	8	of	of	ADP
fnp-3806	724	9	altered	alter	VERB
fnp-3806	724	10	neurovascular	neurovascular	ADJ
fnp-3806	724	11	functioning	functioning	NOUN
fnp-3806	724	12	in	in	ADP
fnp-3806	724	13	sad	sad	ADJ
fnp-3806	724	14	beyond	beyond	ADP
fnp-3806	724	15	that	that	PRON
fnp-3806	724	16	expected	expect	VERB
fnp-3806	724	17	in	in	ADP
fnp-3806	724	18	association	association	NOUN
fnp-3806	724	19	with	with	ADP
fnp-3806	724	20	β	β	NOUN
fnp-3806	724	21	-	-	NOUN
fnp-3806	724	22	amyloid	amyloid	ADJ
fnp-3806	724	23	angiopathy	angiopathy	NOUN
fnp-3806	724	24	.	.	PUNCT
fnp-3806	725	1	neurovascular	neurovascular	ADJ
fnp-3806	725	2	dysfunction	dysfunction	NOUN
fnp-3806	725	3	in	in	ADP
fnp-3806	725	4	individuals	individual	NOUN
fnp-3806	725	5	with	with	ADP
fnp-3806	725	6	mci	mci	PROPN
fnp-3806	725	7	and	and	CCONJ
fnp-3806	725	8	advanced	advanced	ADJ
fnp-3806	725	9	ad	ad	NOUN
fnp-3806	725	10	is	be	AUX
fnp-3806	725	11	manifested	manifest	VERB
fnp-3806	725	12	by	by	ADP
fnp-3806	725	13	reduced	reduce	VERB
fnp-3806	725	14	cbf	cbf	PROPN
fnp-3806	725	15	(	(	PUNCT
fnp-3806	725	16	cerebral	cerebral	ADJ
fnp-3806	725	17	hypoperfusion	hypoperfusion	NOUN
fnp-3806	725	18	)	)	PUNCT
fnp-3806	725	19	,	,	PUNCT
fnp-3806	725	20	reduced	reduce	VERB
fnp-3806	725	21	cerebral	cerebral	ADJ
fnp-3806	725	22	glucose	glucose	NOUN
fnp-3806	725	23	transport	transport	NOUN
fnp-3806	725	24	,	,	PUNCT
fnp-3806	725	25	impaired	impaired	ADJ
fnp-3806	725	26	bbb	bbb	NOUN
fnp-3806	725	27	function	function	NOUN
fnp-3806	725	28	,	,	PUNCT
fnp-3806	725	29	altered	alter	VERB
fnp-3806	725	30	lymphatic	lymphatic	ADJ
fnp-3806	725	31	function	function	NOUN
fnp-3806	725	32	,	,	PUNCT
fnp-3806	725	33	and	and	CCONJ
fnp-3806	725	34	altered	alter	VERB
fnp-3806	725	35	structure	structure	NOUN
fnp-3806	725	36	of	of	ADP
fnp-3806	725	37	the	the	DET
fnp-3806	725	38	capillaries	capillary	NOUN
fnp-3806	725	39	(	(	PUNCT
fnp-3806	725	40	80	80	NUM
fnp-3806	725	41	,	,	PUNCT
fnp-3806	725	42	910	910	NUM
fnp-3806	725	43	,	,	PUNCT
fnp-3806	725	44	924	924	NUM
fnp-3806	725	45	-	-	SYM
fnp-3806	725	46	935	935	NUM
fnp-3806	725	47	)	)	PUNCT
fnp-3806	725	48	.	.	PUNCT
fnp-3806	726	1	in	in	ADP
fnp-3806	726	2	addition	addition	NOUN
fnp-3806	726	3	to	to	ADP
fnp-3806	726	4	atherosclerosis	atherosclerosis	NOUN
fnp-3806	726	5	and	and	CCONJ
fnp-3806	726	6	small	small	ADJ
fnp-3806	726	7	blood	blood	NOUN
fnp-3806	726	8	vessel	vessel	NOUN
fnp-3806	726	9	disease	disease	NOUN
fnp-3806	726	10	that	that	PRON
fnp-3806	726	11	are	be	AUX
fnp-3806	726	12	common	common	ADJ
fnp-3806	726	13	in	in	ADP
fnp-3806	726	14	the	the	DET
fnp-3806	726	15	elderly	elderly	ADJ
fnp-3806	726	16	,	,	PUNCT
fnp-3806	726	17	primary	primary	ADJ
fnp-3806	726	18	involvement	involvement	NOUN
fnp-3806	726	19	of	of	ADP
fnp-3806	726	20	arterioles	arteriole	NOUN
fnp-3806	726	21	and	and	CCONJ
fnp-3806	726	22	capillaries	capillary	NOUN
fnp-3806	726	23	is	be	AUX
fnp-3806	726	24	common	common	ADJ
fnp-3806	726	25	in	in	ADP
fnp-3806	726	26	brain	brain	NOUN
fnp-3806	726	27	aging	aging	NOUN
fnp-3806	726	28	and	and	CCONJ
fnp-3806	726	29	sad	sad	ADJ
fnp-3806	726	30	.	.	PUNCT
fnp-3806	727	1	primary	primary	ADJ
fnp-3806	727	2	blood	blood	NOUN
fnp-3806	727	3	vessel	vessel	NOUN
fnp-3806	727	4	damage	damage	NOUN
fnp-3806	727	5	in	in	ADP
fnp-3806	727	6	sad	sad	ADJ
fnp-3806	727	7	is	be	AUX
fnp-3806	727	8	characterized	characterize	VERB
fnp-3806	727	9	by	by	ADP
fnp-3806	727	10	atrophy	atrophy	NOUN
fnp-3806	727	11	and	and	CCONJ
fnp-3806	727	12	irregularities	irregularity	NOUN
fnp-3806	727	13	of	of	ADP
fnp-3806	727	14	capillaries	capillary	NOUN
fnp-3806	727	15	and	and	CCONJ
fnp-3806	727	16	arterioles	arterioles	PROPN
fnp-3806	727	17	,	,	PUNCT
fnp-3806	727	18	edema	edema	ADJ
fnp-3806	727	19	and	and	CCONJ
fnp-3806	727	20	increased	increase	VERB
fnp-3806	727	21	numbers	number	NOUN
fnp-3806	727	22	of	of	ADP
fnp-3806	727	23	pynocytotic	pynocytotic	ADJ
fnp-3806	727	24	vesicles	vesicle	NOUN
fnp-3806	727	25	in	in	ADP
fnp-3806	727	26	endothelial	endothelial	ADJ
fnp-3806	727	27	cells	cell	NOUN
fnp-3806	727	28	and	and	CCONJ
fnp-3806	727	29	pericytes	pericyte	NOUN
fnp-3806	727	30	,	,	PUNCT
fnp-3806	727	31	atrophy	atrophy	NOUN
fnp-3806	727	32	of	of	ADP
fnp-3806	727	33	smooth	smooth	ADJ
fnp-3806	727	34	muscle	muscle	NOUN
fnp-3806	727	35	fibers	fiber	NOUN
fnp-3806	727	36	,	,	PUNCT
fnp-3806	727	37	thickening	thickening	NOUN
fnp-3806	727	38	and	and	CCONJ
fnp-3806	727	39	focal	focal	ADJ
fnp-3806	727	40	disruption	disruption	NOUN
fnp-3806	727	41	of	of	ADP
fnp-3806	727	42	the	the	DET
fnp-3806	727	43	basal	basal	ADJ
fnp-3806	727	44	membrane	membrane	NOUN
fnp-3806	727	45	,	,	PUNCT
fnp-3806	727	46	increase	increase	NOUN
fnp-3806	727	47	in	in	ADP
fnp-3806	727	48	collagen	collagen	NOUN
fnp-3806	727	49	iv	iv	ADP
fnp-3806	727	50	,	,	PUNCT
fnp-3806	727	51	heparan	heparan	ADJ
fnp-3806	727	52	sulfate	sulfate	NOUN
fnp-3806	727	53	,	,	PUNCT
fnp-3806	727	54	proteoglycans	proteoglycan	NOUN
fnp-3806	727	55	,	,	PUNCT
fnp-3806	727	56	and	and	CCONJ
fnp-3806	727	57	laminin	laminin	NOUN
fnp-3806	727	58	in	in	ADP
fnp-3806	727	59	the	the	DET
fnp-3806	727	60	basal	basal	ADJ
fnp-3806	727	61	membrane	membrane	NOUN
fnp-3806	727	62	,	,	PUNCT
fnp-3806	727	63	increased	increase	VERB
fnp-3806	727	64	aquaporin	aquaporin	NOUN
fnp-3806	727	65	expression	expression	NOUN
fnp-3806	727	66	in	in	ADP
fnp-3806	727	67	perivascular	perivascular	ADJ
fnp-3806	727	68	astrocytes	astrocyte	NOUN
fnp-3806	727	69	,	,	PUNCT
fnp-3806	727	70	and	and	CCONJ
fnp-3806	727	71	gliovascular	gliovascular	ADJ
fnp-3806	727	72	dysfunction	dysfunction	NOUN
fnp-3806	727	73	,	,	PUNCT
fnp-3806	727	74	among	among	ADP
fnp-3806	727	75	other	other	ADJ
fnp-3806	727	76	defects	defect	NOUN
fnp-3806	727	77	(	(	PUNCT
fnp-3806	727	78	910	910	NUM
fnp-3806	727	79	,	,	PUNCT
fnp-3806	727	80	936	936	NUM
fnp-3806	727	81	-	-	SYM
fnp-3806	727	82	941	941	NUM
fnp-3806	727	83	)	)	PUNCT
fnp-3806	727	84	.	.	PUNCT
fnp-3806	728	1	degeneration	degeneration	NOUN
fnp-3806	728	2	of	of	ADP
fnp-3806	728	3	endothelial	endothelial	ADJ
fnp-3806	728	4	cells	cell	NOUN
fnp-3806	728	5	is	be	AUX
fnp-3806	728	6	further	far	ADV
fnp-3806	728	7	supported	support	VERB
fnp-3806	728	8	by	by	ADP
fnp-3806	728	9	reduced	reduced	ADJ
fnp-3806	728	10	staining	staining	NOUN
fnp-3806	728	11	of	of	ADP
fnp-3806	728	12	endothelial	endothelial	ADJ
fnp-3806	728	13	cell	cell	NOUN
fnp-3806	728	14	markers	marker	NOUN
fnp-3806	728	15	(	(	PUNCT
fnp-3806	728	16	942	942	NUM
fnp-3806	728	17	)	)	PUNCT
fnp-3806	728	18	accompanied	accompany	VERB
fnp-3806	728	19	by	by	ADP
fnp-3806	728	20	aberrant	aberrant	ADJ
fnp-3806	728	21	angiogenesis	angiogenesis	NOUN
fnp-3806	728	22	(	(	PUNCT
fnp-3806	728	23	943	943	NUM
fnp-3806	728	24	)	)	PUNCT
fnp-3806	728	25	.	.	PUNCT
fnp-3806	729	1	pericytes	pericyte	NOUN
fnp-3806	729	2	are	be	AUX
fnp-3806	729	3	decreased	decrease	VERB
fnp-3806	729	4	in	in	ADP
fnp-3806	729	5	number	number	NOUN
fnp-3806	729	6	and	and	CCONJ
fnp-3806	729	7	show	show	VERB
fnp-3806	729	8	abnormal	abnormal	ADJ
fnp-3806	729	9	mitochondria	mitochondria	NOUN
fnp-3806	729	10	,	,	PUNCT
fnp-3806	729	11	pinocytotic	pinocytotic	ADJ
fnp-3806	729	12	vesicles	vesicle	NOUN
fnp-3806	729	13	,	,	PUNCT
fnp-3806	729	14	and	and	CCONJ
fnp-3806	729	15	disorganization	disorganization	NOUN
fnp-3806	729	16	and	and	CCONJ
fnp-3806	729	17	accumulation	accumulation	NOUN
fnp-3806	729	18	of	of	ADP
fnp-3806	729	19	osmiophilic	osmiophilic	ADJ
fnp-3806	729	20	material	material	NOUN
fnp-3806	729	21	in	in	ADP
fnp-3806	729	22	aging	age	VERB
fnp-3806	729	23	with	with	ADP
fnp-3806	729	24	cumulative	cumulative	ADJ
fnp-3806	729	25	damage	damage	NOUN
fnp-3806	729	26	with	with	ADP
fnp-3806	729	27	sad	sad	ADJ
fnp-3806	729	28	progression	progression	NOUN
fnp-3806	729	29	(	(	PUNCT
fnp-3806	729	30	944	944	NUM
fnp-3806	729	31	-	-	SYM
fnp-3806	729	32	947	947	NUM
fnp-3806	729	33	)	)	PUNCT
fnp-3806	729	34	.	.	PUNCT
fnp-3806	730	1	aβ	aβ	PRON
fnp-3806	730	2	oligomers	oligomer	NOUN
fnp-3806	730	3	constrict	constrict	VERB
fnp-3806	730	4	human	human	ADJ
fnp-3806	730	5	capillaries	capillary	NOUN
fnp-3806	730	6	in	in	ADP
fnp-3806	730	7	ad	ad	NOUN
fnp-3806	730	8	by	by	ADP
fnp-3806	730	9	signaling	signal	VERB
fnp-3806	730	10	to	to	ADP
fnp-3806	730	11	pericytes	pericyte	NOUN
fnp-3806	730	12	(	(	PUNCT
fnp-3806	730	13	948	948	NUM
fnp-3806	730	14	)	)	PUNCT
fnp-3806	730	15	.	.	PUNCT
fnp-3806	731	1	pericyte	pericyte	NOUN
fnp-3806	731	2	degeneration	degeneration	NOUN
fnp-3806	731	3	and	and	CCONJ
fnp-3806	731	4	impaired	impaired	ADJ
fnp-3806	731	5	bbb	bbb	NOUN
fnp-3806	731	6	function	function	NOUN
fnp-3806	731	7	reduce	reduce	VERB
fnp-3806	731	8	aβ	aβ	DET
fnp-3806	731	9	clearance	clearance	NOUN
fnp-3806	731	10	and	and	CCONJ
fnp-3806	731	11	increase	increase	VERB
fnp-3806	731	12	β	β	NOUN
fnp-3806	731	13	-	-	NOUN
fnp-3806	731	14	amyloid	amyloid	ADJ
fnp-3806	731	15	accumulation	accumulation	NOUN
fnp-3806	731	16	in	in	ADP
fnp-3806	731	17	the	the	DET
fnp-3806	731	18	brain	brain	NOUN
fnp-3806	731	19	.	.	PUNCT
fnp-3806	732	1	importantly	importantly	ADV
fnp-3806	732	2	,	,	PUNCT
fnp-3806	732	3	pericyte	pericyte	NOUN
fnp-3806	732	4	alteration	alteration	NOUN
fnp-3806	732	5	occurs	occur	VERB
fnp-3806	732	6	at	at	ADP
fnp-3806	732	7	early	early	ADJ
fnp-3806	732	8	stages	stage	NOUN
fnp-3806	732	9	of	of	ADP
fnp-3806	732	10	sad	sad	ADJ
fnp-3806	732	11	and	and	CCONJ
fnp-3806	732	12	probably	probably	ADV
fnp-3806	732	13	it	it	PRON
fnp-3806	732	14	has	have	VERB
fnp-3806	732	15	a	a	DET
fnp-3806	732	16	determining	determine	VERB
fnp-3806	732	17	role	role	NOUN
fnp-3806	732	18	in	in	ADP
fnp-3806	732	19	the	the	DET
fnp-3806	732	20	altered	altered	ADJ
fnp-3806	732	21	capillary	capillary	ADJ
fnp-3806	732	22	permeability	permeability	NOUN
fnp-3806	732	23	(	(	PUNCT
fnp-3806	732	24	949	949	NUM
fnp-3806	732	25	-	-	SYM
fnp-3806	732	26	950	950	NUM
fnp-3806	732	27	)	)	PUNCT
fnp-3806	732	28	.	.	PUNCT
fnp-3806	733	1	it	it	PRON
fnp-3806	733	2	is	be	AUX
fnp-3806	733	3	difficult	difficult	ADJ
fnp-3806	733	4	to	to	PART
fnp-3806	733	5	ascertain	ascertain	VERB
fnp-3806	733	6	the	the	DET
fnp-3806	733	7	weight	weight	NOUN
fnp-3806	733	8	of	of	ADP
fnp-3806	733	9	each	each	DET
fnp-3806	733	10	one	one	NUM
fnp-3806	733	11	of	of	ADP
fnp-3806	733	12	the	the	DET
fnp-3806	733	13	vascular	vascular	ADJ
fnp-3806	733	14	pathologies	pathology	NOUN
fnp-3806	733	15	in	in	ADP
fnp-3806	733	16	the	the	DET
fnp-3806	733	17	eventual	eventual	ADJ
fnp-3806	733	18	neurovascular	neurovascular	ADJ
fnp-3806	733	19	failure	failure	NOUN
fnp-3806	733	20	in	in	ADP
fnp-3806	733	21	a	a	DET
fnp-3806	733	22	particular	particular	ADJ
fnp-3806	733	23	individual	individual	NOUN
fnp-3806	733	24	.	.	PUNCT
fnp-3806	734	1	atherosclerosis	atherosclerosis	NOUN
fnp-3806	734	2	,	,	PUNCT
fnp-3806	734	3	small	small	ADJ
fnp-3806	734	4	blood	blood	NOUN
fnp-3806	734	5	vessel	vessel	NOUN
fnp-3806	734	6	disease	disease	NOUN
fnp-3806	734	7	,	,	PUNCT
fnp-3806	734	8	β	β	NOUN
fnp-3806	734	9	-	-	NOUN
fnp-3806	734	10	amyloid	amyloid	ADJ
fnp-3806	734	11	angiopathy	angiopathy	NOUN
fnp-3806	734	12	,	,	PUNCT
fnp-3806	734	13	brain	brain	NOUN
fnp-3806	734	14	hypoperfusion	hypoperfusion	NOUN
fnp-3806	734	15	,	,	PUNCT
fnp-3806	734	16	altered	alter	VERB
fnp-3806	734	17	bbb	bbb	PROPN
fnp-3806	734	18	,	,	PUNCT
fnp-3806	734	19	and	and	CCONJ
fnp-3806	734	20	primary	primary	ADJ
fnp-3806	734	21	ad	ad	NOUN
fnp-3806	734	22	-	-	PUNCT
fnp-3806	734	23	linked	link	VERB
fnp-3806	734	24	non	non	ADJ
fnp-3806	734	25	-	-	ADJ
fnp-3806	734	26	amyloidotic	amyloidotic	ADJ
fnp-3806	734	27	angiopathy	angiopathy	NOUN
fnp-3806	734	28	have	have	VERB
fnp-3806	734	29	cumulative	cumulative	ADJ
fnp-3806	734	30	effects	effect	NOUN
fnp-3806	734	31	(	(	PUNCT
fnp-3806	734	32	951	951	NUM
fnp-3806	734	33	,	,	PUNCT
fnp-3806	734	34	952	952	NUM
fnp-3806	734	35	)	)	PUNCT
fnp-3806	734	36	.	.	PUNCT
fnp-3806	735	1	the	the	DET
fnp-3806	735	2	timing	timing	NOUN
fnp-3806	735	3	and	and	CCONJ
fnp-3806	735	4	development	development	NOUN
fnp-3806	735	5	of	of	ADP
fnp-3806	735	6	neurovascular	neurovascular	ADJ
fnp-3806	735	7	failure	failure	NOUN
fnp-3806	735	8	in	in	ADP
fnp-3806	735	9	sad	sad	ADJ
fnp-3806	735	10	is	be	AUX
fnp-3806	735	11	not	not	PART
fnp-3806	735	12	a	a	DET
fnp-3806	735	13	simple	simple	ADJ
fnp-3806	735	14	process	process	NOUN
fnp-3806	735	15	.	.	PUNCT
fnp-3806	736	1	the	the	DET
fnp-3806	736	2	“	"	PUNCT
fnp-3806	736	3	two	two	NUM
fnp-3806	736	4	-	-	PUNCT
fnp-3806	736	5	hit	hit	VERB
fnp-3806	736	6	vascular	vascular	ADJ
fnp-3806	736	7	hypothesis	hypothesis	NOUN
fnp-3806	736	8	”	"	PUNCT
fnp-3806	736	9	suggests	suggest	VERB
fnp-3806	736	10	that	that	SCONJ
fnp-3806	736	11	early	early	ADJ
fnp-3806	736	12	vascular	vascular	ADJ
fnp-3806	736	13	damage	damage	NOUN
fnp-3806	736	14	leads	lead	VERB
fnp-3806	736	15	to	to	ADP
fnp-3806	736	16	increased	increase	VERB
fnp-3806	736	17	accumulation	accumulation	NOUN
fnp-3806	736	18	of	of	ADP
fnp-3806	736	19	aβ	aβ	DET
fnp-3806	736	20	deposits	deposit	NOUN
fnp-3806	736	21	in	in	ADP
fnp-3806	736	22	the	the	DET
fnp-3806	736	23	brain	brain	NOUN
fnp-3806	736	24	,	,	PUNCT
fnp-3806	736	25	which	which	PRON
fnp-3806	736	26	in	in	ADP
fnp-3806	736	27	turn	turn	NOUN
fnp-3806	736	28	provokes	provoke	VERB
fnp-3806	736	29	additional	additional	ADJ
fnp-3806	736	30	vascular	vascular	ADJ
fnp-3806	736	31	damage	damage	NOUN
fnp-3806	736	32	.	.	PUNCT
fnp-3806	737	1	apoe	apoe	NOUN
fnp-3806	737	2	is	be	AUX
fnp-3806	737	3	one	one	NUM
fnp-3806	737	4	of	of	ADP
fnp-3806	737	5	the	the	DET
fnp-3806	737	6	factors	factor	NOUN
fnp-3806	737	7	that	that	PRON
fnp-3806	737	8	modulate	modulate	VERB
fnp-3806	737	9	cerebrovascular	cerebrovascular	ADJ
fnp-3806	737	10	integrity	integrity	NOUN
fnp-3806	737	11	(	(	PUNCT
fnp-3806	737	12	953	953	NUM
fnp-3806	737	13	)	)	PUNCT
fnp-3806	737	14	.	.	PUNCT
fnp-3806	738	1	impaired	impair	VERB
fnp-3806	738	2	glucose	glucose	NOUN
fnp-3806	738	3	uptake	uptake	NOUN
fnp-3806	738	4	is	be	AUX
fnp-3806	738	5	an	an	DET
fnp-3806	738	6	early	early	ADJ
fnp-3806	738	7	event	event	NOUN
fnp-3806	738	8	in	in	ADP
fnp-3806	738	9	pre	pre	ADJ
fnp-3806	738	10	-	-	ADJ
fnp-3806	738	11	symptomatic	symptomatic	ADJ
fnp-3806	738	12	fad	fad	NOUN
fnp-3806	738	13	(	(	PUNCT
fnp-3806	738	14	954	954	NUM
fnp-3806	738	15	)	)	PUNCT
fnp-3806	738	16	,	,	PUNCT
fnp-3806	738	17	and	and	CCONJ
fnp-3806	738	18	bbb	bbb	NOUN
fnp-3806	738	19	breakdown	breakdown	NOUN
fnp-3806	738	20	is	be	AUX
fnp-3806	738	21	an	an	DET
fnp-3806	738	22	early	early	ADJ
fnp-3806	738	23	biomarker	biomarker	NOUN
fnp-3806	738	24	of	of	ADP
fnp-3806	738	25	human	human	ADJ
fnp-3806	738	26	cognitive	cognitive	ADJ
fnp-3806	738	27	dysfunction	dysfunction	NOUN
fnp-3806	738	28	(	(	PUNCT
fnp-3806	738	29	955	955	NUM
fnp-3806	738	30	)	)	PUNCT
fnp-3806	738	31	,	,	PUNCT
fnp-3806	738	32	suggesting	suggest	VERB
fnp-3806	738	33	that	that	SCONJ
fnp-3806	738	34	the	the	DET
fnp-3806	738	35	neurovascular	neurovascular	ADJ
fnp-3806	738	36	system	system	NOUN
fnp-3806	738	37	is	be	AUX
fnp-3806	738	38	dysfunctional	dysfunctional	ADJ
fnp-3806	738	39	at	at	ADP
fnp-3806	738	40	early	early	ADJ
fnp-3806	738	41	stages	stage	NOUN
fnp-3806	738	42	of	of	ADP
fnp-3806	738	43	ad	ad	NOUN
fnp-3806	738	44	.	.	PUNCT
fnp-3806	739	1	reduced	reduce	VERB
fnp-3806	739	2	expression	expression	NOUN
fnp-3806	739	3	of	of	ADP
fnp-3806	739	4	glucose	glucose	NOUN
fnp-3806	739	5	transporter	transporter	NOUN
fnp-3806	739	6	1	1	NUM
fnp-3806	739	7	(	(	PUNCT
fnp-3806	739	8	glut1	glut1	PROPN
fnp-3806	739	9	)	)	PUNCT
fnp-3806	739	10	is	be	AUX
fnp-3806	739	11	manifested	manifest	VERB
fnp-3806	739	12	at	at	ADP
fnp-3806	739	13	early	early	ADJ
fnp-3806	739	14	stages	stage	NOUN
fnp-3806	739	15	of	of	ADP
fnp-3806	739	16	sad	sad	ADJ
fnp-3806	739	17	,	,	PUNCT
fnp-3806	739	18	and	and	CCONJ
fnp-3806	739	19	it	it	PRON
fnp-3806	739	20	impairs	impair	VERB
fnp-3806	739	21	blood	blood	NOUN
fnp-3806	739	22	glucose	glucose	NOUN
fnp-3806	739	23	uptake	uptake	ADJ
fnp-3806	739	24	and	and	CCONJ
fnp-3806	739	25	vasculo	vasculo	NOUN
fnp-3806	739	26	-	-	PUNCT
fnp-3806	739	27	neuronal	neuronal	ADJ
fnp-3806	739	28	function	function	NOUN
fnp-3806	739	29	(	(	PUNCT
fnp-3806	739	30	956	956	NUM
fnp-3806	739	31	,	,	PUNCT
fnp-3806	739	32	957	957	NUM
fnp-3806	739	33	)	)	PUNCT
fnp-3806	739	34	.	.	PUNCT
fnp-3806	740	1	altered	alter	VERB
fnp-3806	740	2	glucose	glucose	NOUN
fnp-3806	740	3	transport	transport	NOUN
fnp-3806	740	4	accounts	account	NOUN
fnp-3806	740	5	,	,	PUNCT
fnp-3806	740	6	in	in	ADP
fnp-3806	740	7	part	part	NOUN
fnp-3806	740	8	,	,	PUNCT
fnp-3806	740	9	for	for	ADP
fnp-3806	740	10	the	the	DET
fnp-3806	740	11	more	more	ADV
fnp-3806	740	12	complex	complex	ADJ
fnp-3806	740	13	brain	brain	NOUN
fnp-3806	740	14	glucose	glucose	NOUN
fnp-3806	740	15	metabolism	metabolism	NOUN
fnp-3806	740	16	dysregulation	dysregulation	NOUN
fnp-3806	740	17	in	in	ADP
fnp-3806	740	18	ad	ad	NOUN
fnp-3806	740	19	(	(	PUNCT
fnp-3806	740	20	958	958	NUM
fnp-3806	740	21	)	)	PUNCT
fnp-3806	740	22	.	.	PUNCT
fnp-3806	741	1	more	more	ADV
fnp-3806	741	2	precise	precise	ADJ
fnp-3806	741	3	information	information	NOUN
fnp-3806	741	4	has	have	AUX
fnp-3806	741	5	been	be	AUX
fnp-3806	741	6	obtained	obtain	VERB
fnp-3806	741	7	from	from	ADP
fnp-3806	741	8	the	the	DET
fnp-3806	741	9	study	study	NOUN
fnp-3806	741	10	of	of	ADP
fnp-3806	741	11	mouse	mouse	NOUN
fnp-3806	741	12	models	model	NOUN
fnp-3806	741	13	of	of	ADP
fnp-3806	741	14	cerebral	cerebral	ADJ
fnp-3806	741	15	β	β	NOUN
fnp-3806	741	16	-	-	NOUN
fnp-3806	741	17	amyloidosis	amyloidosis	NOUN
fnp-3806	741	18	mimicking	mimicking	ADJ
fnp-3806	741	19	β	β	X
fnp-3806	741	20	-	-	ADJ
fnp-3806	741	21	amyloid	amyloid	ADJ
fnp-3806	741	22	deposits	deposit	NOUN
fnp-3806	741	23	in	in	ADP
fnp-3806	741	24	ad	ad	NOUN
fnp-3806	741	25	(	(	PUNCT
fnp-3806	741	26	959	959	NUM
fnp-3806	741	27	)	)	PUNCT
fnp-3806	741	28	.	.	PUNCT
fnp-3806	742	1	in	in	ADP
fnp-3806	742	2	the	the	DET
fnp-3806	742	3	majority	majority	NOUN
fnp-3806	742	4	of	of	ADP
fnp-3806	742	5	these	these	DET
fnp-3806	742	6	mice	mouse	NOUN
fnp-3806	742	7	,	,	PUNCT
fnp-3806	742	8	cerebral	cerebral	ADJ
fnp-3806	742	9	blood	blood	NOUN
fnp-3806	742	10	vessels	vessel	NOUN
fnp-3806	742	11	are	be	AUX
fnp-3806	742	12	altered	alter	VERB
fnp-3806	742	13	and	and	CCONJ
fnp-3806	742	14	there	there	PRON
fnp-3806	742	15	is	be	VERB
fnp-3806	742	16	often	often	ADV
fnp-3806	742	17	impaired	impaired	ADJ
fnp-3806	742	18	bbb	bbb	NOUN
fnp-3806	742	19	at	at	ADP
fnp-3806	742	20	early	early	ADJ
fnp-3806	742	21	stages	stage	NOUN
fnp-3806	742	22	of	of	ADP
fnp-3806	742	23	aβ	aβ	PRON
fnp-3806	742	24	plaque	plaque	NOUN
fnp-3806	742	25	deposition	deposition	NOUN
fnp-3806	742	26	,	,	PUNCT
fnp-3806	742	27	usually	usually	ADV
fnp-3806	742	28	preceding	precede	VERB
fnp-3806	742	29	or	or	CCONJ
fnp-3806	742	30	in	in	ADP
fnp-3806	742	31	the	the	DET
fnp-3806	742	32	absence	absence	NOUN
fnp-3806	742	33	of	of	ADP
fnp-3806	742	34	β	β	NOUN
fnp-3806	742	35	-	-	NOUN
fnp-3806	742	36	amyloid	amyloid	ADJ
fnp-3806	742	37	angiopathy	angiopathy	NOUN
fnp-3806	742	38	(	(	PUNCT
fnp-3806	742	39	959	959	NUM
fnp-3806	742	40	)	)	PUNCT
fnp-3806	742	41	.	.	PUNCT
fnp-3806	743	1	these	these	DET
fnp-3806	743	2	observations	observation	NOUN
fnp-3806	743	3	are	be	AUX
fnp-3806	743	4	in	in	ADP
fnp-3806	743	5	line	line	NOUN
fnp-3806	743	6	with	with	ADP
fnp-3806	743	7	the	the	DET
fnp-3806	743	8	role	role	NOUN
fnp-3806	743	9	of	of	ADP
fnp-3806	743	10	aβ	aβ	PRON
fnp-3806	743	11	in	in	ADP
fnp-3806	743	12	the	the	DET
fnp-3806	743	13	pathogenesis	pathogenesis	NOUN
fnp-3806	743	14	of	of	ADP
fnp-3806	743	15	neurovascular	neurovascular	ADJ
fnp-3806	743	16	damage	damage	NOUN
fnp-3806	743	17	in	in	ADP
fnp-3806	743	18	ad	ad	NOUN
fnp-3806	743	19	(	(	PUNCT
fnp-3806	743	20	928	928	NUM
fnp-3806	743	21	)	)	PUNCT
fnp-3806	743	22	.	.	PUNCT
fnp-3806	744	1	unfortunately	unfortunately	ADV
fnp-3806	744	2	,	,	PUNCT
fnp-3806	744	3	little	little	ADJ
fnp-3806	744	4	is	be	AUX
fnp-3806	744	5	known	know	VERB
fnp-3806	744	6	about	about	ADP
fnp-3806	744	7	the	the	DET
fnp-3806	744	8	occurrence	occurrence	NOUN
fnp-3806	744	9	of	of	ADP
fnp-3806	744	10	different	different	ADJ
fnp-3806	744	11	soluble	soluble	ADJ
fnp-3806	744	12	,	,	PUNCT
fnp-3806	744	13	insoluble	insoluble	ADJ
fnp-3806	744	14	,	,	PUNCT
fnp-3806	744	15	and	and	CCONJ
fnp-3806	744	16	oligomeric	oligomeric	ADJ
fnp-3806	744	17	amyloid	amyloid	NOUN
fnp-3806	744	18	species	specie	NOUN
fnp-3806	744	19	in	in	ADP
fnp-3806	744	20	these	these	DET
fnp-3806	744	21	models	model	NOUN
fnp-3806	744	22	.	.	PUNCT
fnp-3806	745	1	the	the	DET
fnp-3806	745	2	possible	possible	ADJ
fnp-3806	745	3	deleterious	deleterious	ADJ
fnp-3806	745	4	effects	effect	NOUN
fnp-3806	745	5	of	of	ADP
fnp-3806	745	6	abnormal	abnormal	ADJ
fnp-3806	745	7	tau	tau	NOUN
fnp-3806	745	8	on	on	ADP
fnp-3806	745	9	the	the	DET
fnp-3806	745	10	integrity	integrity	NOUN
fnp-3806	745	11	of	of	ADP
fnp-3806	745	12	the	the	DET
fnp-3806	745	13	cerebral	cerebral	ADJ
fnp-3806	745	14	blood	blood	NOUN
fnp-3806	745	15	vessels	vessel	NOUN
fnp-3806	745	16	have	have	AUX
fnp-3806	745	17	also	also	ADV
fnp-3806	745	18	been	be	AUX
fnp-3806	745	19	assessed	assess	VERB
fnp-3806	745	20	(	(	PUNCT
fnp-3806	745	21	960	960	NUM
fnp-3806	745	22	)	)	PUNCT
fnp-3806	745	23	.	.	PUNCT
fnp-3806	746	1	tau	tau	PROPN
fnp-3806	746	2	expression	expression	NOUN
fnp-3806	746	3	is	be	AUX
fnp-3806	746	4	accompanied	accompany	VERB
fnp-3806	746	5	by	by	ADP
fnp-3806	746	6	bbb	bbb	PROPN
fnp-3806	746	7	breakdown	breakdown	NOUN
fnp-3806	746	8	in	in	ADP
fnp-3806	746	9	tetracycline	tetracycline	NOUN
fnp-3806	746	10	-	-	PUNCT
fnp-3806	746	11	regulable	regulable	ADJ
fnp-3806	746	12	tau	tau	NOUN
fnp-3806	746	13	-	-	PUNCT
fnp-3806	746	14	transgenic	transgenic	ADJ
fnp-3806	746	15	mice	mouse	NOUN
fnp-3806	746	16	;	;	PUNCT
fnp-3806	746	17	bbb	bbb	NUM
fnp-3806	746	18	function	function	NOUN
fnp-3806	746	19	is	be	AUX
fnp-3806	746	20	recovered	recover	VERB
fnp-3806	746	21	once	once	SCONJ
fnp-3806	746	22	tau	tau	PROPN
fnp-3806	746	23	levels	level	NOUN
fnp-3806	746	24	are	be	AUX
fnp-3806	746	25	normalized	normalize	VERB
fnp-3806	746	26	(	(	PUNCT
fnp-3806	746	27	961	961	NUM
fnp-3806	746	28	)	)	PUNCT
fnp-3806	746	29	.	.	PUNCT
fnp-3806	747	1	non	non	ADJ
fnp-3806	747	2	-	-	ADJ
fnp-3806	747	3	structural	structural	ADJ
fnp-3806	747	4	but	but	CCONJ
fnp-3806	747	5	functional	functional	ADJ
fnp-3806	747	6	bbb	bbb	NOUN
fnp-3806	747	7	dysfunction	dysfunction	NOUN
fnp-3806	747	8	mediated	mediate	VERB
fnp-3806	747	9	by	by	ADP
fnp-3806	747	10	altered	altered	ADJ
fnp-3806	747	11	modulation	modulation	NOUN
fnp-3806	747	12	of	of	ADP
fnp-3806	747	13	vasoactive	vasoactive	ADJ
fnp-3806	747	14	factors	factor	NOUN
fnp-3806	747	15	including	include	VERB
fnp-3806	747	16	vasoconstrictor	vasoconstrictor	NOUN
fnp-3806	747	17	endothelin-1	endothelin-1	NUM
fnp-3806	747	18	has	have	AUX
fnp-3806	747	19	been	be	AUX
fnp-3806	747	20	suggested	suggest	VERB
fnp-3806	747	21	(	(	PUNCT
fnp-3806	747	22	962	962	NUM
fnp-3806	747	23	)	)	PUNCT
fnp-3806	747	24	.	.	PUNCT
fnp-3806	748	1	altered	altered	PROPN
fnp-3806	748	2	cbf	cbf	PROPN
fnp-3806	748	3	,	,	PUNCT
fnp-3806	748	4	impaired	impaired	ADJ
fnp-3806	748	5	bbb	bbb	NOUN
fnp-3806	748	6	,	,	PUNCT
fnp-3806	748	7	and	and	CCONJ
fnp-3806	748	8	structural	structural	ADJ
fnp-3806	748	9	anomalies	anomaly	NOUN
fnp-3806	748	10	in	in	ADP
fnp-3806	748	11	the	the	DET
fnp-3806	748	12	blood	blood	NOUN
fnp-3806	748	13	vessels	vessel	NOUN
fnp-3806	748	14	also	also	ADV
fnp-3806	748	15	occur	occur	VERB
fnp-3806	748	16	in	in	ADP
fnp-3806	748	17	other	other	ADJ
fnp-3806	748	18	neurodegenerative	neurodegenerative	ADJ
fnp-3806	748	19	diseases	disease	NOUN
fnp-3806	748	20	such	such	ADJ
fnp-3806	748	21	as	as	ADP
fnp-3806	748	22	parkinson	parkinson	NOUN
fnp-3806	748	23	’s	’s	PART
fnp-3806	748	24	and	and	CCONJ
fnp-3806	748	25	huntington	huntington	PROPN
fnp-3806	748	26	’s	’s	PART
fnp-3806	748	27	diseases	disease	NOUN
fnp-3806	748	28	,	,	PUNCT
fnp-3806	748	29	amyotrophic	amyotrophic	ADJ
fnp-3806	748	30	lateral	lateral	ADJ
fnp-3806	748	31	sclerosis	sclerosis	NOUN
fnp-3806	748	32	,	,	PUNCT
fnp-3806	748	33	and	and	CCONJ
fnp-3806	748	34	multiple	multiple	ADJ
fnp-3806	748	35	sclerosis	sclerosis	NOUN
fnp-3806	748	36	(	(	PUNCT
fnp-3806	748	37	933	933	NUM
fnp-3806	748	38	,	,	PUNCT
fnp-3806	748	39	934	934	NUM
fnp-3806	748	40	,	,	PUNCT
fnp-3806	748	41	963	963	NUM
fnp-3806	748	42	)	)	PUNCT
fnp-3806	748	43	,	,	PUNCT
fnp-3806	748	44	in	in	ADP
fnp-3806	748	45	which	which	PRON
fnp-3806	748	46	aβ	aβ	NOUN
fnp-3806	748	47	and	and	CCONJ
fnp-3806	748	48	ad	ad	NOUN
fnp-3806	748	49	-	-	PUNCT
fnp-3806	748	50	tau	tau	NOUN
fnp-3806	748	51	have	have	VERB
fnp-3806	748	52	no	no	DET
fnp-3806	748	53	chance	chance	NOUN
fnp-3806	748	54	to	to	PART
fnp-3806	748	55	play	play	VERB
fnp-3806	748	56	a	a	DET
fnp-3806	748	57	causative	causative	ADJ
fnp-3806	748	58	role	role	NOUN
fnp-3806	748	59	.	.	PUNCT
fnp-3806	749	1	neurons	neuron	NOUN
fnp-3806	749	2	and	and	CCONJ
fnp-3806	749	3	astrocytes	astrocyte	NOUN
fnp-3806	749	4	also	also	ADV
fnp-3806	749	5	play	play	VERB
fnp-3806	749	6	a	a	DET
fnp-3806	749	7	role	role	NOUN
fnp-3806	749	8	via	via	ADP
fnp-3806	749	9	glutamate	glutamate	NOUN
fnp-3806	749	10	in	in	ADP
fnp-3806	749	11	the	the	DET
fnp-3806	749	12	regulation	regulation	NOUN
fnp-3806	749	13	of	of	ADP
fnp-3806	749	14	cbf	cbf	PROPN
fnp-3806	749	15	.	.	PUNCT
fnp-3806	750	1	arteriole	arteriole	PROPN
fnp-3806	750	2	constriction	constriction	NOUN
fnp-3806	750	3	depends	depend	VERB
fnp-3806	750	4	on	on	ADP
fnp-3806	750	5	the	the	DET
fnp-3806	750	6	metabolism	metabolism	NOUN
fnp-3806	750	7	of	of	ADP
fnp-3806	750	8	arachidonic	arachidonic	ADJ
fnp-3806	750	9	acid	acid	NOUN
fnp-3806	750	10	(	(	PUNCT
fnp-3806	750	11	aa	aa	NOUN
fnp-3806	750	12	)	)	PUNCT
fnp-3806	750	13	.	.	PUNCT
fnp-3806	751	1	upon	upon	SCONJ
fnp-3806	751	2	mglur	mglur	ADJ
fnp-3806	751	3	activation	activation	NOUN
fnp-3806	751	4	,	,	PUNCT
fnp-3806	751	5	increased	increase	VERB
fnp-3806	751	6	aa	aa	NOUN
fnp-3806	751	7	in	in	ADP
fnp-3806	751	8	the	the	DET
fnp-3806	751	9	plasma	plasma	NOUN
fnp-3806	751	10	membrane	membrane	NOUN
fnp-3806	751	11	is	be	AUX
fnp-3806	751	12	converted	convert	VERB
fnp-3806	751	13	into	into	ADP
fnp-3806	751	14	20	20	NUM
fnp-3806	751	15	-	-	PUNCT
fnp-3806	751	16	hydroxyeicosatetraenoic	hydroxyeicosatetraenoic	ADJ
fnp-3806	751	17	acid	acid	NOUN
fnp-3806	751	18	and	and	CCONJ
fnp-3806	751	19	induces	induce	VERB
fnp-3806	751	20	vasoconstriction	vasoconstriction	NOUN
fnp-3806	751	21	,	,	PUNCT
fnp-3806	751	22	or	or	CCONJ
fnp-3806	751	23	it	it	PRON
fnp-3806	751	24	is	be	AUX
fnp-3806	751	25	converted	convert	VERB
fnp-3806	751	26	into	into	ADP
fnp-3806	751	27	prostaglandin	prostaglandin	NOUN
fnp-3806	751	28	2	2	NUM
fnp-3806	751	29	and	and	CCONJ
fnp-3806	751	30	produces	produce	VERB
fnp-3806	751	31	vasodilatation	vasodilatation	NOUN
fnp-3806	751	32	(	(	PUNCT
fnp-3806	751	33	964	964	NUM
fnp-3806	751	34	)	)	PUNCT
fnp-3806	751	35	.	.	PUNCT
fnp-3806	752	1	astrocytes	astrocyte	NOUN
fnp-3806	752	2	have	have	VERB
fnp-3806	752	3	cardinal	cardinal	ADJ
fnp-3806	752	4	functions	function	NOUN
fnp-3806	752	5	in	in	ADP
fnp-3806	752	6	the	the	DET
fnp-3806	752	7	maintenance	maintenance	NOUN
fnp-3806	752	8	of	of	ADP
fnp-3806	752	9	bbb	bbb	PROPN
fnp-3806	752	10	(	(	PUNCT
fnp-3806	752	11	see	see	VERB
fnp-3806	752	12	section	section	NOUN
fnp-3806	752	13	12a	12a	NOUN
fnp-3806	752	14	)	)	PUNCT
fnp-3806	752	15	.	.	PUNCT
fnp-3806	753	1	14	14	NUM
fnp-3806	753	2	.	.	PUNCT
fnp-3806	754	1	purine	purine	NOUN
fnp-3806	754	2	and	and	CCONJ
fnp-3806	754	3	pyrimidine	pyrimidine	NOUN
fnp-3806	754	4	metabolism	metabolism	NOUN
fnp-3806	754	5	in	in	ADP
fnp-3806	754	6	sad	sad	ADJ
fnp-3806	754	7	purines	purine	NOUN
fnp-3806	754	8	are	be	AUX
fnp-3806	754	9	heterocyclic	heterocyclic	ADJ
fnp-3806	754	10	double	double	ADJ
fnp-3806	754	11	-	-	PUNCT
fnp-3806	754	12	ring	ring	NOUN
fnp-3806	754	13	aromatic	aromatic	ADJ
fnp-3806	754	14	organic	organic	ADJ
fnp-3806	754	15	molecules	molecule	NOUN
fnp-3806	754	16	.	.	PUNCT
fnp-3806	755	1	primary	primary	ADJ
fnp-3806	755	2	purines	purine	NOUN
fnp-3806	755	3	adenine	adenine	VERB
fnp-3806	755	4	and	and	CCONJ
fnp-3806	755	5	guanosine	guanosine	NOUN
fnp-3806	755	6	,	,	PUNCT
fnp-3806	755	7	together	together	ADV
fnp-3806	755	8	with	with	ADP
fnp-3806	755	9	one	one	NUM
fnp-3806	755	10	-	-	PUNCT
fnp-3806	755	11	ring	ring	NOUN
fnp-3806	755	12	primary	primary	ADJ
fnp-3806	755	13	pyrimidine	pyrimidine	NOUN
fnp-3806	755	14	nucleobases	nucleobase	NOUN
fnp-3806	755	15	cytosine	cytosine	NOUN
fnp-3806	755	16	,	,	PUNCT
fnp-3806	755	17	thymidine	thymidine	NOUN
fnp-3806	755	18	,	,	PUNCT
fnp-3806	755	19	and	and	CCONJ
fnp-3806	755	20	uracil	uracil	VERB
fnp-3806	755	21	,	,	PUNCT
fnp-3806	755	22	are	be	AUX
fnp-3806	755	23	the	the	DET
fnp-3806	755	24	core	core	NOUN
fnp-3806	755	25	of	of	ADP
fnp-3806	755	26	dna	dna	PROPN
fnp-3806	755	27	,	,	PUNCT
fnp-3806	755	28	rna	rna	NOUN
fnp-3806	755	29	,	,	PUNCT
fnp-3806	755	30	nucleosides	nucleoside	NOUN
fnp-3806	755	31	,	,	PUNCT
fnp-3806	755	32	and	and	CCONJ
fnp-3806	755	33	nucleotides	nucleotide	NOUN
fnp-3806	755	34	.	.	PUNCT
fnp-3806	756	1	adenosine	adenosine	NOUN
fnp-3806	756	2	and	and	CCONJ
fnp-3806	756	3	guanosine	guanosine	NOUN
fnp-3806	756	4	are	be	AUX
fnp-3806	756	5	purine	purine	NOUN
fnp-3806	756	6	ribonucleosides	ribonucleoside	NOUN
fnp-3806	756	7	resulting	result	VERB
fnp-3806	756	8	from	from	ADP
fnp-3806	756	9	the	the	DET
fnp-3806	756	10	binding	binding	NOUN
fnp-3806	756	11	of	of	ADP
fnp-3806	756	12	adenine	adenine	NOUN
fnp-3806	756	13	or	or	CCONJ
fnp-3806	756	14	guanine	guanine	NOUN
fnp-3806	756	15	to	to	PART
fnp-3806	756	16	ribose	ribose	VERB
fnp-3806	756	17	,	,	PUNCT
fnp-3806	756	18	respectively	respectively	ADV
fnp-3806	756	19	.	.	PUNCT
fnp-3806	757	1	when	when	SCONJ
fnp-3806	757	2	adenine	adenine	NOUN
fnp-3806	757	3	and	and	CCONJ
fnp-3806	757	4	guanine	guanine	NOUN
fnp-3806	757	5	are	be	AUX
fnp-3806	757	6	attached	attach	VERB
fnp-3806	757	7	to	to	ADP
fnp-3806	757	8	a	a	DET
fnp-3806	757	9	deoxyribose	deoxyribose	NOUN
fnp-3806	757	10	ring	ring	NOUN
fnp-3806	757	11	,	,	PUNCT
fnp-3806	757	12	the	the	DET
fnp-3806	757	13	resulting	result	VERB
fnp-3806	757	14	compounds	compound	NOUN
fnp-3806	757	15	are	be	AUX
fnp-3806	757	16	deoxyadenosine	deoxyadenosine	ADJ
fnp-3806	757	17	and	and	CCONJ
fnp-3806	757	18	deoxyguanosine	deoxyguanosine	NOUN
fnp-3806	757	19	,	,	PUNCT
fnp-3806	757	20	respectively	respectively	ADV
fnp-3806	757	21	.	.	PUNCT
fnp-3806	758	1	nucleotides	nucleotide	NOUN
fnp-3806	758	2	result	result	VERB
fnp-3806	758	3	from	from	ADP
fnp-3806	758	4	the	the	DET
fnp-3806	758	5	incorporation	incorporation	NOUN
fnp-3806	758	6	of	of	ADP
fnp-3806	758	7	phosphate	phosphate	ADJ
fnp-3806	758	8	groups	group	NOUN
fnp-3806	758	9	in	in	ADP
fnp-3806	758	10	nucleosides	nucleoside	NOUN
fnp-3806	758	11	:	:	PUNCT
fnp-3806	758	12	adenosine	adenosine	ADJ
fnp-3806	758	13	monophosphate	monophosphate	NOUN
fnp-3806	758	14	(	(	PUNCT
fnp-3806	758	15	amp	amp	PROPN
fnp-3806	758	16	)	)	PUNCT
fnp-3806	758	17	,	,	PUNCT
fnp-3806	758	18	adenosine	adenosine	ADJ
fnp-3806	758	19	diphosphate	diphosphate	NOUN
fnp-3806	758	20	,	,	PUNCT
fnp-3806	758	21	adenosine	adenosine	ADJ
fnp-3806	758	22	triphosphate	triphosphate	NOUN
fnp-3806	758	23	(	(	PUNCT
fnp-3806	758	24	atp	atp	PROPN
fnp-3806	758	25	)	)	PUNCT
fnp-3806	758	26	,	,	PUNCT
fnp-3806	758	27	guanosine	guanosine	NOUN
fnp-3806	758	28	monophosphate	monophosphate	NOUN
fnp-3806	758	29	(	(	PUNCT
fnp-3806	758	30	gmp	gmp	PROPN
fnp-3806	758	31	)	)	PUNCT
fnp-3806	758	32	,	,	PUNCT
fnp-3806	758	33	guanosine	guanosine	PROPN
fnp-3806	758	34	diphosphate	diphosphate	PROPN
fnp-3806	758	35	,	,	PUNCT
fnp-3806	758	36	guanosine	guanosine	NOUN
fnp-3806	758	37	triphosphate	triphosphate	NOUN
fnp-3806	758	38	,	,	PUNCT
fnp-3806	758	39	and	and	CCONJ
fnp-3806	758	40	cyclic	cyclic	ADJ
fnp-3806	758	41	forms	form	NOUN
fnp-3806	758	42	camp	camp	NOUN
fnp-3806	758	43	and	and	CCONJ
fnp-3806	758	44	cgmp	cgmp	PROPN
fnp-3806	758	45	are	be	AUX
fnp-3806	758	46	primary	primary	ADJ
fnp-3806	758	47	purine	purine	NOUN
fnp-3806	758	48	-	-	PUNCT
fnp-3806	758	49	derived	derive	VERB
fnp-3806	758	50	nucleotides	nucleotide	NOUN
fnp-3806	758	51	.	.	PUNCT
fnp-3806	759	1	modified	modify	VERB
fnp-3806	759	2	purine	purine	NOUN
fnp-3806	759	3	nucleobases	nucleobase	NOUN
fnp-3806	759	4	hypoxantine	hypoxantine	NOUN
fnp-3806	759	5	and	and	CCONJ
fnp-3806	759	6	xanthine	xanthine	NOUN
fnp-3806	759	7	result	result	VERB
fnp-3806	759	8	from	from	ADP
fnp-3806	759	9	the	the	DET
fnp-3806	759	10	replacement	replacement	NOUN
fnp-3806	759	11	of	of	ADP
fnp-3806	759	12	the	the	DET
fnp-3806	759	13	amino	amino	NOUN
fnp-3806	759	14	-	-	PUNCT
fnp-3806	759	15	group	group	NOUN
fnp-3806	759	16	by	by	ADP
fnp-3806	759	17	a	a	DET
fnp-3806	759	18	carbonyl	carbonyl	NOUN
fnp-3806	759	19	-	-	PUNCT
fnp-3806	759	20	group	group	NOUN
fnp-3806	759	21	from	from	ADP
fnp-3806	759	22	adenine	adenine	NOUN
fnp-3806	759	23	and	and	CCONJ
fnp-3806	759	24	guanine	guanine	NOUN
fnp-3806	759	25	,	,	PUNCT
fnp-3806	759	26	respectively	respectively	ADV
fnp-3806	759	27	,	,	PUNCT
fnp-3806	759	28	whereas	whereas	SCONJ
fnp-3806	759	29	methyl	methyl	NOUN
fnp-3806	759	30	-	-	PUNCT
fnp-3806	759	31	guanine	guanine	NOUN
fnp-3806	759	32	results	result	NOUN
fnp-3806	759	33	from	from	ADP
fnp-3806	759	34	the	the	DET
fnp-3806	759	35	incorporation	incorporation	NOUN
fnp-3806	759	36	of	of	ADP
fnp-3806	759	37	a	a	DET
fnp-3806	759	38	methyl	methyl	NOUN
fnp-3806	759	39	group	group	NOUN
fnp-3806	759	40	to	to	ADP
fnp-3806	759	41	guanine	guanine	NOUN
fnp-3806	759	42	.	.	PUNCT
fnp-3806	760	1	corresponding	correspond	VERB
fnp-3806	760	2	modified	modify	VERB
fnp-3806	760	3	purine	purine	NOUN
fnp-3806	760	4	nucleosides	nucleoside	NOUN
fnp-3806	760	5	are	be	AUX
fnp-3806	760	6	inosine	inosine	NOUN
fnp-3806	760	7	,	,	PUNCT
fnp-3806	760	8	xanthosine	xanthosine	PROPN
fnp-3806	760	9	,	,	PUNCT
fnp-3806	760	10	and	and	CCONJ
fnp-3806	760	11	methyl	methyl	NOUN
fnp-3806	760	12	-	-	PUNCT
fnp-3806	760	13	guanosine	guanosine	NOUN
fnp-3806	760	14	,	,	PUNCT
fnp-3806	760	15	respectively	respectively	ADV
fnp-3806	760	16	.	.	PUNCT
fnp-3806	761	1	nucleotides	nucleotide	NOUN
fnp-3806	761	2	participate	participate	VERB
fnp-3806	761	3	in	in	ADP
fnp-3806	761	4	a	a	DET
fnp-3806	761	5	wide	wide	ADJ
fnp-3806	761	6	variety	variety	NOUN
fnp-3806	761	7	of	of	ADP
fnp-3806	761	8	crucial	crucial	ADJ
fnp-3806	761	9	metabolic	metabolic	NOUN
fnp-3806	761	10	pathways	pathway	NOUN
fnp-3806	761	11	including	include	VERB
fnp-3806	761	12	energy	energy	NOUN
fnp-3806	761	13	metabolism	metabolism	NOUN
fnp-3806	761	14	and	and	CCONJ
fnp-3806	761	15	cell	cell	NOUN
fnp-3806	761	16	signaling	signal	VERB
fnp-3806	761	17	.	.	PUNCT
fnp-3806	762	1	in	in	ADP
fnp-3806	762	2	addition	addition	NOUN
fnp-3806	762	3	,	,	PUNCT
fnp-3806	762	4	purine	purine	NOUN
fnp-3806	762	5	bases	basis	NOUN
fnp-3806	762	6	are	be	AUX
fnp-3806	762	7	incorporated	incorporate	VERB
fnp-3806	762	8	to	to	ADP
fnp-3806	762	9	other	other	ADJ
fnp-3806	762	10	molecules	molecule	NOUN
fnp-3806	762	11	to	to	PART
fnp-3806	762	12	form	form	VERB
fnp-3806	762	13	cofactors	cofactor	NOUN
fnp-3806	762	14	of	of	ADP
fnp-3806	762	15	several	several	ADJ
fnp-3806	762	16	enzymatic	enzymatic	ADJ
fnp-3806	762	17	reactions	reaction	NOUN
fnp-3806	762	18	such	such	ADJ
fnp-3806	762	19	as	as	ADP
fnp-3806	762	20	coenzyme	coenzyme	PROPN
fnp-3806	762	21	a	a	PRON
fnp-3806	762	22	,	,	PUNCT
fnp-3806	762	23	flavin	flavin	ADJ
fnp-3806	762	24	adenine	adenine	ADJ
fnp-3806	762	25	dinucleotide	dinucleotide	NOUN
fnp-3806	762	26	(	(	PUNCT
fnp-3806	762	27	fad	fad	NOUN
fnp-3806	762	28	)	)	PUNCT
fnp-3806	762	29	,	,	PUNCT
fnp-3806	762	30	nicotinamide	nicotinamide	NOUN
fnp-3806	762	31	adenine	adenine	ADJ
fnp-3806	762	32	dinucleotide	dinucleotide	NOUN
fnp-3806	762	33	(	(	PUNCT
fnp-3806	762	34	nadþ	nadþ	NOUN
fnp-3806	762	35	)	)	PUNCT
fnp-3806	762	36	,	,	PUNCT
fnp-3806	762	37	nicotinamide	nicotinamide	NOUN
fnp-3806	762	38	adenine	adenine	ADJ
fnp-3806	762	39	dinucleotide	dinucleotide	NOUN
fnp-3806	762	40	phosphate	phosphate	NOUN
fnp-3806	762	41	(	(	PUNCT
fnp-3806	762	42	nadpþ	nadpþ	NOUN
fnp-3806	762	43	)	)	PUNCT
fnp-3806	762	44	,	,	PUNCT
fnp-3806	762	45	and	and	CCONJ
fnp-3806	762	46	the	the	DET
fnp-3806	762	47	corresponding	corresponding	ADJ
fnp-3806	762	48	reduced	reduce	VERB
fnp-3806	762	49	forms	form	NOUN
fnp-3806	762	50	fadh2	fadh2	PROPN
fnp-3806	762	51	,	,	PUNCT
fnp-3806	762	52	nadh	nadh	NOUN
fnp-3806	762	53	,	,	PUNCT
fnp-3806	762	54	and	and	CCONJ
fnp-3806	762	55	nadph	nadph	PROPN
fnp-3806	762	56	.	.	PUNCT
fnp-3806	763	1	s	s	X
fnp-3806	763	2	-	-	PUNCT
fnp-3806	763	3	adenosyl	adenosyl	ADJ
fnp-3806	763	4	methionine	methionine	NOUN
fnp-3806	763	5	is	be	AUX
fnp-3806	763	6	made	make	VERB
fnp-3806	763	7	from	from	ADP
fnp-3806	763	8	atp	atp	PROPN
fnp-3806	763	9	and	and	CCONJ
fnp-3806	763	10	methionine	methionine	NOUN
fnp-3806	763	11	by	by	ADP
fnp-3806	763	12	methionine	methionine	NOUN
fnp-3806	763	13	adenosyltransferase	adenosyltransferase	NOUN
fnp-3806	763	14	and	and	CCONJ
fnp-3806	763	15	is	be	AUX
fnp-3806	763	16	involved	involve	VERB
fnp-3806	763	17	in	in	ADP
fnp-3806	763	18	the	the	DET
fnp-3806	763	19	transfer	transfer	NOUN
fnp-3806	763	20	of	of	ADP
fnp-3806	763	21	methyl	methyl	NOUN
fnp-3806	763	22	groups	group	NOUN
fnp-3806	763	23	to	to	ADP
fnp-3806	763	24	distinct	distinct	ADJ
fnp-3806	763	25	substrates	substrate	NOUN
fnp-3806	763	26	,	,	PUNCT
fnp-3806	763	27	including	include	VERB
fnp-3806	763	28	nucleic	nucleic	ADJ
fnp-3806	763	29	acids	acid	NOUN
fnp-3806	763	30	,	,	PUNCT
fnp-3806	763	31	proteins	protein	NOUN
fnp-3806	763	32	,	,	PUNCT
fnp-3806	763	33	lipids	lipid	NOUN
fnp-3806	763	34	,	,	PUNCT
fnp-3806	763	35	and	and	CCONJ
fnp-3806	763	36	metabolites	metabolite	NOUN
fnp-3806	763	37	(	(	PUNCT
fnp-3806	763	38	965	965	NUM
fnp-3806	763	39	,	,	PUNCT
fnp-3806	763	40	966	966	NUM
fnp-3806	763	41	)	)	PUNCT
fnp-3806	763	42	.	.	PUNCT
fnp-3806	764	1	in	in	ADP
fnp-3806	764	2	addition	addition	NOUN
fnp-3806	764	3	,	,	PUNCT
fnp-3806	764	4	adenosine	adenosine	NOUN
fnp-3806	764	5	may	may	AUX
fnp-3806	764	6	act	act	VERB
fnp-3806	764	7	as	as	ADP
fnp-3806	764	8	neuromodulator	neuromodulator	NOUN
fnp-3806	764	9	on	on	ADP
fnp-3806	764	10	specific	specific	ADJ
fnp-3806	764	11	adenosine	adenosine	NOUN
fnp-3806	764	12	receptors	receptor	NOUN
fnp-3806	764	13	(	(	PUNCT
fnp-3806	764	14	967	967	NUM
fnp-3806	764	15	)	)	PUNCT
fnp-3806	764	16	(	(	PUNCT
fnp-3806	764	17	see	see	VERB
fnp-3806	764	18	section	section	NOUN
fnp-3806	764	19	7f	7f	NOUN
fnp-3806	764	20	)	)	PUNCT
fnp-3806	764	21	.	.	PUNCT
fnp-3806	765	1	adenosine	adenosine	NOUN
fnp-3806	765	2	receptors	receptor	NOUN
fnp-3806	765	3	also	also	ADV
fnp-3806	765	4	modulate	modulate	VERB
fnp-3806	765	5	the	the	DET
fnp-3806	765	6	bbb	bbb	PROPN
fnp-3806	765	7	(	(	PUNCT
fnp-3806	765	8	968	968	NUM
fnp-3806	765	9	)	)	PUNCT
fnp-3806	765	10	.	.	PUNCT
fnp-3806	766	1	significantly	significantly	ADV
fnp-3806	766	2	decreased	decrease	VERB
fnp-3806	766	3	levels	level	NOUN
fnp-3806	766	4	of	of	ADP
fnp-3806	766	5	adenosine	adenosine	NOUN
fnp-3806	766	6	,	,	PUNCT
fnp-3806	766	7	guanosine	guanosine	NOUN
fnp-3806	766	8	,	,	PUNCT
fnp-3806	766	9	hypoxanthine	hypoxanthine	NOUN
fnp-3806	766	10	,	,	PUNCT
fnp-3806	766	11	and	and	CCONJ
fnp-3806	766	12	xanthine	xanthine	NOUN
fnp-3806	766	13	are	be	AUX
fnp-3806	766	14	found	find	VERB
fnp-3806	766	15	in	in	ADP
fnp-3806	766	16	the	the	DET
fnp-3806	766	17	frontal	frontal	ADJ
fnp-3806	766	18	cortex	cortex	NOUN
fnp-3806	766	19	at	at	ADP
fnp-3806	766	20	stages	stage	NOUN
fnp-3806	766	21	i	i	PROPN
fnp-3806	766	22	-	-	PUNCT
fnp-3806	766	23	ii	ii	PROPN
fnp-3806	766	24	of	of	ADP
fnp-3806	766	25	nft	nft	PROPN
fnp-3806	766	26	pathology	pathology	PROPN
fnp-3806	766	27	,	,	PUNCT
fnp-3806	766	28	but	but	CCONJ
fnp-3806	766	29	the	the	DET
fnp-3806	766	30	parietal	parietal	ADJ
fnp-3806	766	31	cortex	cortex	NOUN
fnp-3806	766	32	and	and	CCONJ
fnp-3806	766	33	temporal	temporal	ADJ
fnp-3806	766	34	cortex	cortex	NOUN
fnp-3806	766	35	show	show	VERB
fnp-3806	766	36	an	an	DET
fnp-3806	766	37	opposing	oppose	VERB
fnp-3806	766	38	pattern	pattern	NOUN
fnp-3806	766	39	at	at	ADP
fnp-3806	766	40	advanced	advanced	ADJ
fnp-3806	766	41	stages	stage	NOUN
fnp-3806	766	42	of	of	ADP
fnp-3806	766	43	sad	sad	ADJ
fnp-3806	766	44	.	.	PUNCT
fnp-3806	767	1	the	the	DET
fnp-3806	767	2	activity	activity	NOUN
fnp-3806	767	3	of	of	ADP
fnp-3806	767	4	5’-nucleotidase	5’-nucleotidase	NUM
fnp-3806	767	5	,	,	PUNCT
fnp-3806	767	6	which	which	PRON
fnp-3806	767	7	hydrolizes	hydrolize	VERB
fnp-3806	767	8	adenosine	adenosine	ADJ
fnp-3806	767	9	amp	amp	NOUN
fnp-3806	767	10	to	to	PART
fnp-3806	767	11	generate	generate	VERB
fnp-3806	767	12	adenosine	adenosine	NOUN
fnp-3806	767	13	,	,	PUNCT
fnp-3806	767	14	is	be	AUX
fnp-3806	767	15	reduced	reduce	VERB
fnp-3806	767	16	in	in	ADP
fnp-3806	767	17	the	the	DET
fnp-3806	767	18	frontal	frontal	ADJ
fnp-3806	767	19	cortex	cortex	NOUN
fnp-3806	767	20	mainly	mainly	ADV
fnp-3806	767	21	at	at	ADP
fnp-3806	767	22	nft	nft	PROPN
fnp-3806	767	23	stages	stage	NOUN
fnp-3806	767	24	i	i	PROPN
fnp-3806	767	25	-	-	PUNCT
fnp-3806	767	26	ii	ii	PROPN
fnp-3806	767	27	,	,	PUNCT
fnp-3806	767	28	and	and	CCONJ
fnp-3806	767	29	only	only	ADV
fnp-3806	767	30	at	at	ADP
fnp-3806	767	31	nft	nft	PROPN
fnp-3806	767	32	stages	stage	NOUN
fnp-3806	767	33	v	v	PROPN
fnp-3806	767	34	-	-	PUNCT
fnp-3806	767	35	vi	vi	NOUN
fnp-3806	767	36	in	in	ADP
fnp-3806	767	37	the	the	DET
fnp-3806	767	38	temporal	temporal	ADJ
fnp-3806	767	39	cortex	cortex	NOUN
fnp-3806	767	40	.	.	PUNCT
fnp-3806	768	1	adenosine	adenosine	ADJ
fnp-3806	768	2	deaminase	deaminase	NOUN
fnp-3806	768	3	activity	activity	NOUN
fnp-3806	768	4	,	,	PUNCT
fnp-3806	768	5	which	which	PRON
fnp-3806	768	6	synthetizes	synthetize	VERB
fnp-3806	768	7	inosine	inosine	NOUN
fnp-3806	768	8	from	from	ADP
fnp-3806	768	9	adenosine	adenosine	NOUN
fnp-3806	768	10	,	,	PUNCT
fnp-3806	768	11	is	be	AUX
fnp-3806	768	12	decreased	decrease	VERB
fnp-3806	768	13	in	in	ADP
fnp-3806	768	14	the	the	DET
fnp-3806	768	15	frontal	frontal	ADJ
fnp-3806	768	16	cortex	cortex	NOUN
fnp-3806	768	17	in	in	ADP
fnp-3806	768	18	sad	sad	ADJ
fnp-3806	768	19	but	but	CCONJ
fnp-3806	768	20	is	be	AUX
fnp-3806	768	21	increased	increase	VERB
fnp-3806	768	22	at	at	ADP
fnp-3806	768	23	nft	nft	PROPN
fnp-3806	768	24	stages	stage	NOUN
fnp-3806	768	25	i	i	PROPN
fnp-3806	768	26	-	-	PUNCT
fnp-3806	768	27	ii	ii	PROPN
fnp-3806	768	28	in	in	ADP
fnp-3806	768	29	the	the	DET
fnp-3806	768	30	temporal	temporal	ADJ
fnp-3806	768	31	cortex	cortex	NOUN
fnp-3806	768	32	.	.	PUNCT
fnp-3806	769	1	finally	finally	ADV
fnp-3806	769	2	,	,	PUNCT
fnp-3806	769	3	purine	purine	NOUN
fnp-3806	769	4	nucleoside	nucleoside	NOUN
fnp-3806	769	5	phosphorylase	phosphorylase	NOUN
fnp-3806	769	6	activity	activity	NOUN
fnp-3806	769	7	,	,	PUNCT
fnp-3806	769	8	which	which	PRON
fnp-3806	769	9	metabolizes	metabolize	VERB
fnp-3806	769	10	guanosine	guanosine	NOUN
fnp-3806	769	11	to	to	ADP
fnp-3806	769	12	guanine	guanine	NOUN
fnp-3806	769	13	,	,	PUNCT
fnp-3806	769	14	is	be	AUX
fnp-3806	769	15	increased	increase	VERB
fnp-3806	769	16	only	only	ADV
fnp-3806	769	17	in	in	ADP
fnp-3806	769	18	the	the	DET
fnp-3806	769	19	temporal	temporal	ADJ
fnp-3806	769	20	cortex	cortex	NOUN
fnp-3806	769	21	at	at	ADP
fnp-3806	769	22	nft	nft	PROPN
fnp-3806	769	23	stages	stage	NOUN
fnp-3806	769	24	i	i	PROPN
fnp-3806	769	25	-	-	PUNCT
fnp-3806	769	26	ii	ii	PROPN
fnp-3806	769	27	.	.	PUNCT
fnp-3806	770	1	purine	purine	NOUN
fnp-3806	770	2	metabolism	metabolism	NOUN
fnp-3806	770	3	alterations	alteration	NOUN
fnp-3806	770	4	are	be	AUX
fnp-3806	770	5	regionand	regionand	NOUN
fnp-3806	770	6	stage	stage	NOUN
fnp-3806	770	7	-	-	PUNCT
fnp-3806	770	8	dependent	dependent	ADJ
fnp-3806	770	9	and	and	CCONJ
fnp-3806	770	10	occur	occur	VERB
fnp-3806	770	11	independently	independently	ADV
fnp-3806	770	12	of	of	ADP
fnp-3806	770	13	nfts	nft	NOUN
fnp-3806	770	14	and	and	CCONJ
fnp-3806	770	15	β	β	NOUN
fnp-3806	770	16	-	-	ADJ
fnp-3806	770	17	amyloid	amyloid	ADJ
fnp-3806	770	18	plaques	plaque	NOUN
fnp-3806	770	19	(	(	PUNCT
fnp-3806	770	20	969	969	NUM
fnp-3806	770	21	)	)	PUNCT
fnp-3806	770	22	.	.	PUNCT
fnp-3806	771	1	in	in	ADP
fnp-3806	771	2	another	another	DET
fnp-3806	771	3	study	study	NOUN
fnp-3806	771	4	,	,	PUNCT
fnp-3806	771	5	23	23	NUM
fnp-3806	771	6	purine	purine	NOUN
fnp-3806	771	7	metabolism	metabolism	NOUN
fnp-3806	771	8	genes	gene	NOUN
fnp-3806	771	9	were	be	AUX
fnp-3806	771	10	analyzed	analyze	VERB
fnp-3806	771	11	with	with	ADP
fnp-3806	771	12	rt	rt	NOUN
fnp-3806	771	13	-	-	PUNCT
fnp-3806	771	14	pcr	pcr	NOUN
fnp-3806	771	15	in	in	ADP
fnp-3806	771	16	the	the	DET
fnp-3806	771	17	entorhinal	entorhinal	ADJ
fnp-3806	771	18	cortex	cortex	NOUN
fnp-3806	771	19	,	,	PUNCT
fnp-3806	771	20	frontal	frontal	ADJ
fnp-3806	771	21	cortex	cortex	NOUN
fnp-3806	771	22	area	area	NOUN
fnp-3806	771	23	8	8	NUM
fnp-3806	771	24	,	,	PUNCT
fnp-3806	771	25	and	and	CCONJ
fnp-3806	771	26	precuneus	precuneus	NOUN
fnp-3806	771	27	in	in	ADP
fnp-3806	771	28	ma	ma	PROPN
fnp-3806	771	29	individuals	individual	NOUN
fnp-3806	771	30	without	without	ADP
fnp-3806	771	31	nft	nft	PROPN
fnp-3806	771	32	pathology	pathology	PROPN
fnp-3806	771	33	and	and	CCONJ
fnp-3806	771	34	in	in	ADP
fnp-3806	771	35	cases	case	NOUN
fnp-3806	771	36	at	at	ADP
fnp-3806	771	37	nft	nft	PROPN
fnp-3806	771	38	stages	stage	NOUN
fnp-3806	771	39	i	i	PROPN
fnp-3806	771	40	-	-	PUNCT
fnp-3806	771	41	ii	ii	PROPN
fnp-3806	771	42	,	,	PUNCT
fnp-3806	771	43	iii	iii	X
fnp-3806	771	44	-	-	PUNCT
fnp-3806	771	45	iv	iv	NOUN
fnp-3806	771	46	,	,	PUNCT
fnp-3806	771	47	and	and	CCONJ
fnp-3806	771	48	v	v	NOUN
fnp-3806	771	49	-	-	PUNCT
fnp-3806	771	50	vi	vi	NOUN
fnp-3806	771	51	(	(	PUNCT
fnp-3806	771	52	966	966	NUM
fnp-3806	771	53	)	)	PUNCT
fnp-3806	771	54	.	.	PUNCT
fnp-3806	772	1	the	the	DET
fnp-3806	772	2	mrna	mrna	PROPN
fnp-3806	772	3	expression	expression	NOUN
fnp-3806	772	4	levels	level	NOUN
fnp-3806	772	5	of	of	ADP
fnp-3806	772	6	several	several	ADJ
fnp-3806	772	7	enzymes	enzyme	NOUN
fnp-3806	772	8	were	be	AUX
fnp-3806	772	9	dysregulated	dysregulate	VERB
fnp-3806	772	10	at	at	ADP
fnp-3806	772	11	stages	stage	NOUN
fnp-3806	772	12	iii	iii	NOUN
fnp-3806	772	13	-	-	PUNCT
fnp-3806	772	14	iv	iv	NUM
fnp-3806	772	15	and	and	CCONJ
fnp-3806	772	16	v	v	NOUN
fnp-3806	772	17	-	-	PUNCT
fnp-3806	772	18	vi	vi	NOUN
fnp-3806	772	19	in	in	ADP
fnp-3806	772	20	a	a	DET
fnp-3806	772	21	region	region	NOUN
fnp-3806	772	22	-	-	PUNCT
fnp-3806	772	23	dependent	dependent	ADJ
fnp-3806	772	24	manner	manner	NOUN
fnp-3806	772	25	when	when	SCONJ
fnp-3806	772	26	compared	compare	VERB
fnp-3806	772	27	with	with	ADP
fnp-3806	772	28	ma	ma	PROPN
fnp-3806	772	29	individuals	individual	NOUN
fnp-3806	772	30	.	.	PUNCT
fnp-3806	773	1	in	in	ADP
fnp-3806	773	2	addition	addition	NOUN
fnp-3806	773	3	,	,	PUNCT
fnp-3806	773	4	liquid	liquid	ADJ
fnp-3806	773	5	chromatography	chromatography	NOUN
fnp-3806	773	6	mass	mass	NOUN
fnp-3806	773	7	spectrometry	spectrometry	NOUN
fnp-3806	773	8	-	-	PUNCT
fnp-3806	773	9	based	base	VERB
fnp-3806	773	10	metabolomics	metabolomic	NOUN
fnp-3806	773	11	in	in	ADP
fnp-3806	773	12	the	the	DET
fnp-3806	773	13	entorhinal	entorhinal	ADJ
fnp-3806	773	14	cortex	cortex	NOUN
fnp-3806	773	15	identified	identify	VERB
fnp-3806	773	16	decreased	decrease	VERB
fnp-3806	773	17	levels	level	NOUN
fnp-3806	773	18	of	of	ADP
fnp-3806	773	19	xanthosine	xanthosine	PROPN
fnp-3806	773	20	,	,	PUNCT
fnp-3806	773	21	guanine	guanine	NOUN
fnp-3806	773	22	,	,	PUNCT
fnp-3806	773	23	and	and	CCONJ
fnp-3806	773	24	deoxyguanosine	deoxyguanosine	NOUN
fnp-3806	773	25	at	at	ADP
fnp-3806	773	26	stages	stage	NOUN
fnp-3806	773	27	i	i	PROPN
fnp-3806	773	28	-	-	PUNCT
fnp-3806	773	29	ii	ii	PROPN
fnp-3806	773	30	,	,	PUNCT
fnp-3806	773	31	followed	follow	VERB
fnp-3806	773	32	by	by	ADP
fnp-3806	773	33	dgmp	dgmp	NOUN
fnp-3806	773	34	,	,	PUNCT
fnp-3806	773	35	inosine	inosine	NOUN
fnp-3806	773	36	diphosphate	diphosphate	NOUN
fnp-3806	773	37	,	,	PUNCT
fnp-3806	773	38	and	and	CCONJ
fnp-3806	773	39	glycine	glycine	NOUN
fnp-3806	773	40	at	at	ADP
fnp-3806	773	41	nft	nft	PROPN
fnp-3806	773	42	stages	stages	PROPN
fnp-3806	773	43	iii	iii	NOUN
fnp-3806	773	44	-	-	PUNCT
fnp-3806	773	45	iv	iv	NOUN
fnp-3806	773	46	in	in	ADP
fnp-3806	773	47	sad	sad	ADJ
fnp-3806	773	48	(	(	PUNCT
fnp-3806	773	49	966	966	NUM
fnp-3806	773	50	)	)	PUNCT
fnp-3806	773	51	.	.	PUNCT
fnp-3806	774	1	some	some	DET
fnp-3806	774	2	years	year	NOUN
fnp-3806	774	3	ago	ago	ADV
fnp-3806	774	4	,	,	PUNCT
fnp-3806	774	5	studies	study	NOUN
fnp-3806	774	6	pointed	point	VERB
fnp-3806	774	7	to	to	ADP
fnp-3806	774	8	s	s	NOUN
fnp-3806	774	9	-	-	PUNCT
fnp-3806	774	10	adenosylmethionine	adenosylmethionine	NOUN
fnp-3806	774	11	as	as	ADP
fnp-3806	774	12	a	a	DET
fnp-3806	774	13	complementary	complementary	ADJ
fnp-3806	774	14	candidate	candidate	NOUN
fnp-3806	774	15	for	for	ADP
fnp-3806	774	16	therapeutic	therapeutic	ADJ
fnp-3806	774	17	intervention	intervention	NOUN
fnp-3806	774	18	in	in	ADP
fnp-3806	774	19	sad	sad	ADJ
fnp-3806	774	20	(	(	PUNCT
fnp-3806	774	21	208	208	NUM
fnp-3806	774	22	,	,	PUNCT
fnp-3806	774	23	970	970	NUM
fnp-3806	774	24	)	)	PUNCT
fnp-3806	774	25	.	.	PUNCT
fnp-3806	775	1	more	more	ADV
fnp-3806	775	2	recently	recently	ADV
fnp-3806	775	3	,	,	PUNCT
fnp-3806	775	4	several	several	ADJ
fnp-3806	775	5	studies	study	NOUN
fnp-3806	775	6	have	have	AUX
fnp-3806	775	7	scrutinized	scrutinize	VERB
fnp-3806	775	8	the	the	DET
fnp-3806	775	9	modulation	modulation	NOUN
fnp-3806	775	10	of	of	ADP
fnp-3806	775	11	purinergic	purinergic	NOUN
fnp-3806	775	12	signaling	signal	VERB
fnp-3806	775	13	to	to	PART
fnp-3806	775	14	ameliorate	ameliorate	VERB
fnp-3806	775	15	sad	sad	ADJ
fnp-3806	775	16	(	(	PUNCT
fnp-3806	775	17	971	971	NUM
fnp-3806	775	18	-	-	SYM
fnp-3806	775	19	976	976	NUM
fnp-3806	775	20	)	)	PUNCT
fnp-3806	775	21	.	.	PUNCT
fnp-3806	776	1	considering	consider	VERB
fnp-3806	776	2	the	the	DET
fnp-3806	776	3	large	large	ADJ
fnp-3806	776	4	number	number	NOUN
fnp-3806	776	5	of	of	ADP
fnp-3806	776	6	different	different	ADJ
fnp-3806	776	7	enzymes	enzyme	NOUN
fnp-3806	776	8	altered	alter	VERB
fnp-3806	776	9	,	,	PUNCT
fnp-3806	776	10	this	this	PRON
fnp-3806	776	11	represents	represent	VERB
fnp-3806	776	12	a	a	DET
fnp-3806	776	13	tremendous	tremendous	ADJ
fnp-3806	776	14	endeavor	endeavor	NOUN
fnp-3806	776	15	.	.	PUNCT
fnp-3806	777	1	15	15	NUM
fnp-3806	777	2	.	.	PUNCT
fnp-3806	778	1	epigenetics	epigenetic	NOUN
fnp-3806	778	2	in	in	ADP
fnp-3806	778	3	brain	brain	NOUN
fnp-3806	778	4	aging	aging	NOUN
fnp-3806	778	5	and	and	CCONJ
fnp-3806	778	6	sad	sad	ADJ
fnp-3806	778	7	epigenetic	epigenetic	ADJ
fnp-3806	778	8	regulation	regulation	NOUN
fnp-3806	778	9	plays	play	VERB
fnp-3806	778	10	a	a	DET
fnp-3806	778	11	crucial	crucial	ADJ
fnp-3806	778	12	role	role	NOUN
fnp-3806	778	13	in	in	ADP
fnp-3806	778	14	the	the	DET
fnp-3806	778	15	final	final	ADJ
fnp-3806	778	16	transcription	transcription	NOUN
fnp-3806	778	17	of	of	ADP
fnp-3806	778	18	genes	gene	NOUN
fnp-3806	778	19	(	(	PUNCT
fnp-3806	778	20	977	977	NUM
fnp-3806	778	21	,	,	PUNCT
fnp-3806	778	22	978	978	NUM
fnp-3806	778	23	)	)	PUNCT
fnp-3806	778	24	.	.	PUNCT
fnp-3806	779	1	three	three	NUM
fnp-3806	779	2	central	central	ADJ
fnp-3806	779	3	mechanisms	mechanism	NOUN
fnp-3806	779	4	are	be	AUX
fnp-3806	779	5	briefly	briefly	ADV
fnp-3806	779	6	discussed	discuss	VERB
fnp-3806	779	7	:	:	PUNCT
fnp-3806	779	8	modifications	modification	NOUN
fnp-3806	779	9	of	of	ADP
fnp-3806	779	10	histones	histone	NOUN
fnp-3806	779	11	,	,	PUNCT
fnp-3806	779	12	dna	dna	PROPN
fnp-3806	779	13	methylation	methylation	NOUN
fnp-3806	779	14	and	and	CCONJ
fnp-3806	779	15	hydroxymethylation	hydroxymethylation	NOUN
fnp-3806	779	16	,	,	PUNCT
fnp-3806	779	17	and	and	CCONJ
fnp-3806	779	18	non	non	ADJ
fnp-3806	779	19	-	-	ADJ
fnp-3806	779	20	coding	coding	ADJ
fnp-3806	779	21	rnas	rna	NOUN
fnp-3806	779	22	.	.	PUNCT
fnp-3806	780	1	15a	15a	NOUN
fnp-3806	780	2	.	.	PUNCT
fnp-3806	781	1	histone	histone	NOUN
fnp-3806	781	2	modifications	modification	NOUN
fnp-3806	781	3	,	,	PUNCT
fnp-3806	781	4	dna	dna	PROPN
fnp-3806	781	5	methylation	methylation	NOUN
fnp-3806	781	6	,	,	PUNCT
fnp-3806	781	7	and	and	CCONJ
fnp-3806	781	8	hydroxymethylation	hydroxymethylation	NOUN
fnp-3806	781	9	nucleosomes	nucleosome	NOUN
fnp-3806	781	10	consist	consist	VERB
fnp-3806	781	11	of	of	ADP
fnp-3806	781	12	dna	dna	PROPN
fnp-3806	781	13	wound	wind	VERB
fnp-3806	781	14	around	around	ADP
fnp-3806	781	15	a	a	DET
fnp-3806	781	16	protein	protein	NOUN
fnp-3806	781	17	octamer	octamer	NOUN
fnp-3806	781	18	composed	compose	VERB
fnp-3806	781	19	of	of	ADP
fnp-3806	781	20	two	two	NUM
fnp-3806	781	21	molecules	molecule	NOUN
fnp-3806	781	22	of	of	ADP
fnp-3806	781	23	the	the	DET
fnp-3806	781	24	histones	histone	NOUN
fnp-3806	781	25	h2a	h2a	PROPN
fnp-3806	781	26	,	,	PUNCT
fnp-3806	781	27	h2b	h2b	PROPN
fnp-3806	781	28	,	,	PUNCT
fnp-3806	781	29	h3	h3	NOUN
fnp-3806	781	30	,	,	PUNCT
fnp-3806	781	31	and	and	CCONJ
fnp-3806	781	32	h4	h4	PROPN
fnp-3806	781	33	.	.	PUNCT
fnp-3806	782	1	the	the	DET
fnp-3806	782	2	n	n	CCONJ
fnp-3806	782	3	-	-	PUNCT
fnp-3806	782	4	terminal	terminal	NOUN
fnp-3806	782	5	of	of	ADP
fnp-3806	782	6	histones	histone	NOUN
fnp-3806	782	7	(	(	PUNCT
fnp-3806	782	8	histone	histone	NOUN
fnp-3806	782	9	tail	tail	NOUN
fnp-3806	782	10	)	)	PUNCT
fnp-3806	782	11	extends	extend	VERB
fnp-3806	782	12	out	out	ADP
fnp-3806	782	13	from	from	ADP
fnp-3806	782	14	the	the	DET
fnp-3806	782	15	surface	surface	NOUN
fnp-3806	782	16	of	of	ADP
fnp-3806	782	17	the	the	DET
fnp-3806	782	18	nucleosome	nucleosome	PROPN
fnp-3806	782	19	.	.	PUNCT
fnp-3806	783	1	acetylations	acetylation	NOUN
fnp-3806	783	2	by	by	ADP
fnp-3806	783	3	histone	histone	NOUN
fnp-3806	783	4	acetyltransferases	acetyltransferase	NOUN
fnp-3806	783	5	(	(	PUNCT
fnp-3806	783	6	hats	hat	NOUN
fnp-3806	783	7	)	)	PUNCT
fnp-3806	783	8	and	and	CCONJ
fnp-3806	783	9	histone	histone	NOUN
fnp-3806	783	10	deacetylases	deacetylase	NOUN
fnp-3806	783	11	(	(	PUNCT
fnp-3806	783	12	hdacs	hdac	NOUN
fnp-3806	783	13	)	)	PUNCT
fnp-3806	783	14	,	,	PUNCT
fnp-3806	783	15	and	and	CCONJ
fnp-3806	783	16	methylation	methylation	NOUN
fnp-3806	783	17	mediated	mediate	VERB
fnp-3806	783	18	by	by	ADP
fnp-3806	783	19	histone	histone	NOUN
fnp-3806	783	20	methyltransferases	methyltransferase	NOUN
fnp-3806	783	21	(	(	PUNCT
fnp-3806	783	22	hmts	hmts	NOUN
fnp-3806	783	23	)	)	PUNCT
fnp-3806	783	24	and	and	CCONJ
fnp-3806	783	25	histone	histone	NOUN
fnp-3806	783	26	demethylases	demethylase	NOUN
fnp-3806	783	27	(	(	PUNCT
fnp-3806	783	28	hdms	hdms	ADV
fnp-3806	783	29	)	)	PUNCT
fnp-3806	783	30	,	,	PUNCT
fnp-3806	783	31	respectively	respectively	ADV
fnp-3806	783	32	,	,	PUNCT
fnp-3806	783	33	occur	occur	VERB
fnp-3806	783	34	at	at	ADP
fnp-3806	783	35	the	the	DET
fnp-3806	783	36	histone	histone	NOUN
fnp-3806	783	37	tails	tail	NOUN
fnp-3806	783	38	(	(	PUNCT
fnp-3806	783	39	979	979	NUM
fnp-3806	783	40	,	,	PUNCT
fnp-3806	783	41	980	980	NUM
fnp-3806	783	42	)	)	PUNCT
fnp-3806	783	43	.	.	PUNCT
fnp-3806	784	1	histone	histone	NOUN
fnp-3806	784	2	acetylation	acetylation	NOUN
fnp-3806	784	3	decreases	decrease	VERB
fnp-3806	784	4	the	the	DET
fnp-3806	784	5	interactions	interaction	NOUN
fnp-3806	784	6	of	of	ADP
fnp-3806	784	7	histones	histone	NOUN
fnp-3806	784	8	with	with	ADP
fnp-3806	784	9	dna	dna	PROPN
fnp-3806	784	10	,	,	PUNCT
fnp-3806	784	11	relaxes	relax	VERB
fnp-3806	784	12	heterochromatin	heterochromatin	NOUN
fnp-3806	784	13	to	to	PART
fnp-3806	784	14	euchromatin	euchromatin	VERB
fnp-3806	784	15	,	,	PUNCT
fnp-3806	784	16	and	and	CCONJ
fnp-3806	784	17	enables	enable	VERB
fnp-3806	784	18	gene	gene	NOUN
fnp-3806	784	19	transcription	transcription	NOUN
fnp-3806	784	20	(	(	PUNCT
fnp-3806	784	21	981	981	NUM
fnp-3806	784	22	-	-	SYM
fnp-3806	784	23	984	984	NUM
fnp-3806	784	24	)	)	PUNCT
fnp-3806	784	25	.	.	PUNCT
fnp-3806	785	1	methylation	methylation	NOUN
fnp-3806	785	2	of	of	ADP
fnp-3806	785	3	histones	histone	NOUN
fnp-3806	785	4	can	can	AUX
fnp-3806	785	5	either	either	CCONJ
fnp-3806	785	6	increase	increase	VERB
fnp-3806	785	7	or	or	CCONJ
fnp-3806	785	8	decrease	decrease	VERB
fnp-3806	785	9	gene	gene	NOUN
fnp-3806	785	10	transcription	transcription	NOUN
fnp-3806	785	11	,	,	PUNCT
fnp-3806	785	12	depending	depend	VERB
fnp-3806	785	13	on	on	ADP
fnp-3806	785	14	which	which	PRON
fnp-3806	785	15	amino	amino	NOUN
fnp-3806	785	16	acids	acid	NOUN
fnp-3806	785	17	in	in	ADP
fnp-3806	785	18	the	the	DET
fnp-3806	785	19	histones	histone	NOUN
fnp-3806	785	20	are	be	AUX
fnp-3806	785	21	methylated	methylate	VERB
fnp-3806	785	22	,	,	PUNCT
fnp-3806	785	23	and	and	CCONJ
fnp-3806	785	24	on	on	ADP
fnp-3806	785	25	the	the	DET
fnp-3806	785	26	number	number	NOUN
fnp-3806	785	27	of	of	ADP
fnp-3806	785	28	methyl	methyl	NOUN
fnp-3806	785	29	groups	group	NOUN
fnp-3806	785	30	involved	involve	VERB
fnp-3806	785	31	.	.	PUNCT
fnp-3806	786	1	methylations	methylation	NOUN
fnp-3806	786	2	,	,	PUNCT
fnp-3806	786	3	which	which	PRON
fnp-3806	786	4	permit	permit	VERB
fnp-3806	786	5	dna	dna	NOUN
fnp-3806	786	6	uncoiling	uncoil	VERB
fnp-3806	786	7	facilitate	facilitate	VERB
fnp-3806	786	8	the	the	DET
fnp-3806	786	9	access	access	NOUN
fnp-3806	786	10	of	of	ADP
fnp-3806	786	11	transcription	transcription	NOUN
fnp-3806	786	12	factors	factor	NOUN
fnp-3806	786	13	and	and	CCONJ
fnp-3806	786	14	rna	rna	NOUN
fnp-3806	786	15	polymerase	polymerase	NOUN
fnp-3806	786	16	.	.	PUNCT
fnp-3806	787	1	the	the	DET
fnp-3806	787	2	trimethylation	trimethylation	NOUN
fnp-3806	787	3	of	of	ADP
fnp-3806	787	4	histone	histone	NOUN
fnp-3806	787	5	3	3	NUM
fnp-3806	787	6	at	at	ADP
fnp-3806	787	7	lysine	lysine	NOUN
fnp-3806	787	8	4	4	NUM
fnp-3806	787	9	(	(	PUNCT
fnp-3806	787	10	h3k4m3	h3k4m3	NOUN
fnp-3806	787	11	)	)	PUNCT
fnp-3806	787	12	activates	activate	VERB
fnp-3806	787	13	transcription	transcription	NOUN
fnp-3806	787	14	,	,	PUNCT
fnp-3806	787	15	whereas	whereas	SCONJ
fnp-3806	787	16	dimethylation	dimethylation	NOUN
fnp-3806	787	17	of	of	ADP
fnp-3806	787	18	histone	histone	NOUN
fnp-3806	787	19	h3	h3	NOUN
fnp-3806	787	20	at	at	ADP
fnp-3806	787	21	lysine	lysine	NOUN
fnp-3806	787	22	9	9	NUM
fnp-3806	787	23	(	(	PUNCT
fnp-3806	787	24	h3k9me2	h3k9me2	X
fnp-3806	787	25	)	)	PUNCT
fnp-3806	787	26	is	be	AUX
fnp-3806	787	27	inhibitory	inhibitory	ADJ
fnp-3806	787	28	.	.	PUNCT
fnp-3806	788	1	likewise	likewise	ADV
fnp-3806	788	2	,	,	PUNCT
fnp-3806	788	3	methylation	methylation	NOUN
fnp-3806	788	4	of	of	ADP
fnp-3806	788	5	lysine	lysine	NOUN
fnp-3806	788	6	4	4	NUM
fnp-3806	788	7	of	of	ADP
fnp-3806	788	8	histone	histone	NOUN
fnp-3806	788	9	3	3	NUM
fnp-3806	788	10	(	(	PUNCT
fnp-3806	788	11	h3k4me1	h3k4me1	X
fnp-3806	788	12	)	)	PUNCT
fnp-3806	788	13	facilitates	facilitate	VERB
fnp-3806	788	14	gene	gene	NOUN
fnp-3806	788	15	transcription	transcription	NOUN
fnp-3806	788	16	(	(	PUNCT
fnp-3806	788	17	985	985	NUM
fnp-3806	788	18	-	-	SYM
fnp-3806	788	19	988	988	NUM
fnp-3806	788	20	)	)	PUNCT
fnp-3806	788	21	.	.	PUNCT
fnp-3806	789	1	dna	dna	PROPN
fnp-3806	789	2	methylation	methylation	NOUN
fnp-3806	789	3	and	and	CCONJ
fnp-3806	789	4	dna	dna	PROPN
fnp-3806	789	5	hydroxymethylation	hydroxymethylation	NOUN
fnp-3806	789	6	are	be	AUX
fnp-3806	789	7	biological	biological	ADJ
fnp-3806	789	8	processes	process	NOUN
fnp-3806	789	9	by	by	ADP
fnp-3806	789	10	which	which	PRON
fnp-3806	789	11	methyl	methyl	NOUN
fnp-3806	789	12	or	or	CCONJ
fnp-3806	789	13	hydroxymethyl	hydroxymethyl	NOUN
fnp-3806	789	14	groups	group	NOUN
fnp-3806	789	15	are	be	AUX
fnp-3806	789	16	added	add	VERB
fnp-3806	789	17	to	to	ADP
fnp-3806	789	18	the	the	DET
fnp-3806	789	19	dna	dna	PROPN
fnp-3806	789	20	.	.	PUNCT
fnp-3806	790	1	methylation	methylation	NOUN
fnp-3806	790	2	and	and	CCONJ
fnp-3806	790	3	hydroxymethylation	hydroxymethylation	NOUN
fnp-3806	790	4	can	can	AUX
fnp-3806	790	5	change	change	VERB
fnp-3806	790	6	the	the	DET
fnp-3806	790	7	activity	activity	NOUN
fnp-3806	790	8	of	of	ADP
fnp-3806	790	9	a	a	DET
fnp-3806	790	10	dna	dna	NOUN
fnp-3806	790	11	segment	segment	NOUN
fnp-3806	790	12	without	without	ADP
fnp-3806	790	13	changing	change	VERB
fnp-3806	790	14	the	the	DET
fnp-3806	790	15	sequence	sequence	NOUN
fnp-3806	790	16	.	.	PUNCT
fnp-3806	791	1	the	the	DET
fnp-3806	791	2	methylation	methylation	NOUN
fnp-3806	791	3	of	of	ADP
fnp-3806	791	4	a	a	DET
fnp-3806	791	5	5′-cytosine	5′-cytosine	PROPN
fnp-3806	791	6	in	in	ADP
fnp-3806	791	7	cytosine	cytosine	NOUN
fnp-3806	791	8	-	-	PUNCT
fnp-3806	791	9	guanine	guanine	ADJ
fnp-3806	791	10	-	-	PUNCT
fnp-3806	791	11	rich	rich	ADJ
fnp-3806	791	12	regions	region	NOUN
fnp-3806	791	13	(	(	PUNCT
fnp-3806	791	14	cpg	cpg	NOUN
fnp-3806	791	15	islands	island	NOUN
fnp-3806	791	16	)	)	PUNCT
fnp-3806	791	17	of	of	ADP
fnp-3806	791	18	dna	dna	PROPN
fnp-3806	791	19	promoters	promoter	NOUN
fnp-3806	791	20	results	result	VERB
fnp-3806	791	21	mainly	mainly	ADV
fnp-3806	791	22	in	in	ADP
fnp-3806	791	23	the	the	DET
fnp-3806	791	24	inability	inability	NOUN
fnp-3806	791	25	of	of	ADP
fnp-3806	791	26	transcription	transcription	NOUN
fnp-3806	791	27	factors	factor	NOUN
fnp-3806	791	28	to	to	PART
fnp-3806	791	29	bind	bind	VERB
fnp-3806	791	30	dna	dna	NOUN
fnp-3806	791	31	and	and	CCONJ
fnp-3806	791	32	compact	compact	ADJ
fnp-3806	791	33	heterochromatin	heterochromatin	NOUN
fnp-3806	791	34	;	;	PUNCT
fnp-3806	791	35	as	as	ADP
fnp-3806	791	36	a	a	DET
fnp-3806	791	37	result	result	NOUN
fnp-3806	791	38	,	,	PUNCT
fnp-3806	791	39	gene	gene	NOUN
fnp-3806	791	40	transcription	transcription	NOUN
fnp-3806	791	41	is	be	AUX
fnp-3806	791	42	silenced	silence	VERB
fnp-3806	791	43	.	.	PUNCT
fnp-3806	792	1	four	four	NUM
fnp-3806	792	2	types	type	NOUN
fnp-3806	792	3	of	of	ADP
fnp-3806	792	4	dna	dna	PROPN
fnp-3806	792	5	methyltransferases	methyltransferase	NOUN
fnp-3806	792	6	,	,	PUNCT
fnp-3806	792	7	dnmt1	dnmt1	PROPN
fnp-3806	792	8	,	,	PUNCT
fnp-3806	792	9	dnmt2	dnmt2	ADJ
fnp-3806	792	10	,	,	PUNCT
fnp-3806	792	11	dnmt3a	dnmt3a	NOUN
fnp-3806	792	12	,	,	PUNCT
fnp-3806	792	13	and	and	CCONJ
fnp-3806	792	14	dnmt3b	dnmt3b	ADJ
fnp-3806	792	15	,	,	PUNCT
fnp-3806	792	16	carry	carry	VERB
fnp-3806	792	17	out	out	ADP
fnp-3806	792	18	the	the	DET
fnp-3806	792	19	process	process	NOUN
fnp-3806	792	20	of	of	ADP
fnp-3806	792	21	dna	dna	PROPN
fnp-3806	792	22	methylation	methylation	NOUN
fnp-3806	792	23	.	.	PUNCT
fnp-3806	793	1	s	s	X
fnp-3806	793	2	-	-	PUNCT
fnp-3806	793	3	adenosyl	adenosyl	ADJ
fnp-3806	793	4	-	-	PUNCT
fnp-3806	793	5	l	l	NOUN
fnp-3806	793	6	-	-	NOUN
fnp-3806	793	7	methionine	methionine	NOUN
fnp-3806	793	8	(	(	PUNCT
fnp-3806	793	9	sam	sam	PROPN
fnp-3806	793	10	)	)	PUNCT
fnp-3806	793	11	is	be	AUX
fnp-3806	793	12	the	the	DET
fnp-3806	793	13	donor	donor	NOUN
fnp-3806	793	14	of	of	ADP
fnp-3806	793	15	methyl	methyl	NOUN
fnp-3806	793	16	groups	group	NOUN
fnp-3806	793	17	.	.	PUNCT
fnp-3806	794	1	dna	dna	PROPN
fnp-3806	794	2	hydroxymethylation	hydroxymethylation	PROPN
fnp-3806	794	3	can	can	AUX
fnp-3806	794	4	occur	occur	VERB
fnp-3806	794	5	as	as	ADP
fnp-3806	794	6	a	a	DET
fnp-3806	794	7	result	result	NOUN
fnp-3806	794	8	of	of	ADP
fnp-3806	794	9	oxidative	oxidative	ADJ
fnp-3806	794	10	stress	stress	NOUN
fnp-3806	794	11	or	or	CCONJ
fnp-3806	794	12	the	the	DET
fnp-3806	794	13	action	action	NOUN
fnp-3806	794	14	of	of	ADP
fnp-3806	794	15	ten	ten	NUM
fnp-3806	794	16	-	-	PUNCT
fnp-3806	794	17	eleven	eleven	NUM
fnp-3806	794	18	-	-	PUNCT
fnp-3806	794	19	translocation-1	translocation-1	NUM
fnp-3806	794	20	(	(	PUNCT
fnp-3806	794	21	tet1	tet1	NOUN
fnp-3806	794	22	)	)	PUNCT
fnp-3806	794	23	proteins	protein	NOUN
fnp-3806	794	24	(	(	PUNCT
fnp-3806	794	25	989	989	NUM
fnp-3806	794	26	-	-	SYM
fnp-3806	794	27	994	994	NUM
fnp-3806	794	28	)	)	PUNCT
fnp-3806	794	29	.	.	PUNCT
fnp-3806	795	1	sam	sam	PROPN
fnp-3806	795	2	which	which	PRON
fnp-3806	795	3	is	be	AUX
fnp-3806	795	4	generated	generate	VERB
fnp-3806	795	5	by	by	ADP
fnp-3806	795	6	adding	add	VERB
fnp-3806	795	7	adenosine	adenosine	NOUN
fnp-3806	795	8	to	to	ADP
fnp-3806	795	9	methionine	methionine	NOUN
fnp-3806	795	10	,	,	PUNCT
fnp-3806	795	11	a	a	DET
fnp-3806	795	12	reaction	reaction	NOUN
fnp-3806	795	13	catalyzed	catalyze	VERB
fnp-3806	795	14	by	by	ADP
fnp-3806	795	15	s	s	NOUN
fnp-3806	795	16	-	-	PUNCT
fnp-3806	795	17	adenosyl	adenosyl	ADJ
fnp-3806	795	18	-	-	PUNCT
fnp-3806	795	19	methionine	methionine	NOUN
fnp-3806	795	20	transferase	transferase	NOUN
fnp-3806	795	21	,	,	PUNCT
fnp-3806	795	22	transfers	transfer	VERB
fnp-3806	795	23	the	the	DET
fnp-3806	795	24	methyl	methyl	NOUN
fnp-3806	795	25	group	group	NOUN
fnp-3806	795	26	to	to	ADP
fnp-3806	795	27	dna	dna	PROPN
fnp-3806	795	28	methylation	methylation	NOUN
fnp-3806	795	29	by	by	ADP
fnp-3806	795	30	dna	dna	PROPN
fnp-3806	795	31	methyltransferase	methyltransferase	NOUN
fnp-3806	795	32	.	.	PUNCT
fnp-3806	796	1	brain	brain	NOUN
fnp-3806	796	2	aging	aging	NOUN
fnp-3806	796	3	and	and	CCONJ
fnp-3806	796	4	sad	sad	ADJ
fnp-3806	796	5	is	be	AUX
fnp-3806	796	6	accompanied	accompany	VERB
fnp-3806	796	7	by	by	ADP
fnp-3806	796	8	epigenetic	epigenetic	ADJ
fnp-3806	796	9	dna	dna	PROPN
fnp-3806	796	10	modifications	modification	NOUN
fnp-3806	796	11	(	(	PUNCT
fnp-3806	796	12	995	995	NUM
fnp-3806	796	13	-	-	PUNCT
fnp-3806	796	14	1002	1002	NUM
fnp-3806	796	15	)	)	PUNCT
fnp-3806	796	16	.	.	PUNCT
fnp-3806	797	1	dna	dna	PROPN
fnp-3806	797	2	modifications	modification	NOUN
fnp-3806	797	3	involve	involve	VERB
fnp-3806	797	4	genes	gene	NOUN
fnp-3806	797	5	linked	link	VERB
fnp-3806	797	6	to	to	ADP
fnp-3806	797	7	β	β	NOUN
fnp-3806	797	8	-	-	NOUN
fnp-3806	797	9	amyloid	amyloid	ADJ
fnp-3806	797	10	production	production	NOUN
fnp-3806	797	11	(	(	PUNCT
fnp-3806	797	12	1003	1003	NUM
fnp-3806	797	13	-	-	SYM
fnp-3806	797	14	1006	1006	NUM
fnp-3806	797	15	)	)	PUNCT
fnp-3806	797	16	,	,	PUNCT
fnp-3806	797	17	apoe	apoe	PROPN
fnp-3806	797	18	-	-	PUNCT
fnp-3806	797	19	ε4	ε4	NOUN
fnp-3806	797	20	(	(	PUNCT
fnp-3806	797	21	996	996	NUM
fnp-3806	797	22	)	)	PUNCT
fnp-3806	797	23	,	,	PUNCT
fnp-3806	797	24	tau	tau	PROPN
fnp-3806	797	25	phosphorylation	phosphorylation	NOUN
fnp-3806	797	26	(	(	PUNCT
fnp-3806	797	27	1007	1007	NUM
fnp-3806	797	28	-	-	SYM
fnp-3806	797	29	1009	1009	NUM
fnp-3806	797	30	)	)	PUNCT
fnp-3806	797	31	,	,	PUNCT
fnp-3806	797	32	ribosomes	ribosome	NOUN
fnp-3806	797	33	(	(	PUNCT
fnp-3806	797	34	1010	1010	NUM
fnp-3806	797	35	)	)	PUNCT
fnp-3806	797	36	,	,	PUNCT
fnp-3806	797	37	bdnf	bdnf	X
fnp-3806	797	38	(	(	PUNCT
fnp-3806	797	39	1011	1011	NUM
fnp-3806	797	40	)	)	PUNCT
fnp-3806	797	41	,	,	PUNCT
fnp-3806	797	42	and	and	CCONJ
fnp-3806	797	43	inflammation	inflammation	NOUN
fnp-3806	797	44	(	(	PUNCT
fnp-3806	797	45	1012	1012	NUM
fnp-3806	797	46	,	,	PUNCT
fnp-3806	797	47	1013	1013	NUM
fnp-3806	797	48	)	)	PUNCT
fnp-3806	797	49	.	.	PUNCT
fnp-3806	798	1	a	a	DET
fnp-3806	798	2	large	large	ADJ
fnp-3806	798	3	number	number	NOUN
fnp-3806	798	4	of	of	ADP
fnp-3806	798	5	unrelated	unrelated	ADJ
fnp-3806	798	6	genes	gene	NOUN
fnp-3806	798	7	has	have	AUX
fnp-3806	798	8	also	also	ADV
fnp-3806	798	9	been	be	AUX
fnp-3806	798	10	assessed	assess	VERB
fnp-3806	798	11	,	,	PUNCT
fnp-3806	798	12	showing	show	VERB
fnp-3806	798	13	either	either	CCONJ
fnp-3806	798	14	changes	change	NOUN
fnp-3806	798	15	or	or	CCONJ
fnp-3806	798	16	no	no	DET
fnp-3806	798	17	modifications	modification	NOUN
fnp-3806	798	18	in	in	ADP
fnp-3806	798	19	the	the	DET
fnp-3806	798	20	methylation	methylation	NOUN
fnp-3806	798	21	of	of	ADP
fnp-3806	798	22	dna	dna	PROPN
fnp-3806	798	23	promoters	promoter	NOUN
fnp-3806	798	24	(	(	PUNCT
fnp-3806	798	25	1014	1014	NUM
fnp-3806	798	26	-	-	SYM
fnp-3806	798	27	1023	1023	NUM
fnp-3806	798	28	)	)	PUNCT
fnp-3806	798	29	.	.	PUNCT
fnp-3806	799	1	the	the	DET
fnp-3806	799	2	expression	expression	NOUN
fnp-3806	799	3	of	of	ADP
fnp-3806	799	4	adenosine	adenosine	ADJ
fnp-3806	799	5	receptor	receptor	NOUN
fnp-3806	799	6	a2a	a2a	PROPN
fnp-3806	799	7	is	be	AUX
fnp-3806	799	8	modulated	modulate	VERB
fnp-3806	799	9	by	by	ADP
fnp-3806	799	10	dna	dna	PROPN
fnp-3806	799	11	methylation	methylation	NOUN
fnp-3806	799	12	in	in	ADP
fnp-3806	799	13	the	the	DET
fnp-3806	799	14	gene	gene	NOUN
fnp-3806	799	15	promoter	promoter	NOUN
fnp-3806	799	16	region	region	NOUN
fnp-3806	799	17	(	(	PUNCT
fnp-3806	799	18	1024	1024	NUM
fnp-3806	799	19	-	-	SYM
fnp-3806	799	20	1026	1026	NUM
fnp-3806	799	21	)	)	PUNCT
fnp-3806	799	22	.	.	PUNCT
fnp-3806	800	1	therefore	therefore	ADV
fnp-3806	800	2	,	,	PUNCT
fnp-3806	800	3	epigenetic	epigenetic	ADJ
fnp-3806	800	4	changes	change	NOUN
fnp-3806	800	5	in	in	ADP
fnp-3806	800	6	dna	dna	NOUN
fnp-3806	800	7	in	in	ADP
fnp-3806	800	8	aging	age	VERB
fnp-3806	800	9	and	and	CCONJ
fnp-3806	800	10	sad	sad	ADJ
fnp-3806	800	11	are	be	AUX
fnp-3806	800	12	not	not	PART
fnp-3806	800	13	widespread	widespread	ADJ
fnp-3806	800	14	but	but	CCONJ
fnp-3806	800	15	selective	selective	ADJ
fnp-3806	800	16	for	for	ADP
fnp-3806	800	17	particular	particular	ADJ
fnp-3806	800	18	genes	gene	NOUN
fnp-3806	800	19	.	.	PUNCT
fnp-3806	801	1	in	in	ADP
fnp-3806	801	2	monozygotic	monozygotic	ADJ
fnp-3806	801	3	twins	twin	NOUN
fnp-3806	801	4	discordant	discordant	ADJ
fnp-3806	801	5	for	for	ADP
fnp-3806	801	6	ad	ad	NOUN
fnp-3806	801	7	,	,	PUNCT
fnp-3806	801	8	significantly	significantly	ADV
fnp-3806	801	9	reduced	reduce	VERB
fnp-3806	801	10	levels	level	NOUN
fnp-3806	801	11	of	of	ADP
fnp-3806	801	12	dna	dna	PROPN
fnp-3806	801	13	methylation	methylation	NOUN
fnp-3806	801	14	were	be	AUX
fnp-3806	801	15	observed	observe	VERB
fnp-3806	801	16	in	in	ADP
fnp-3806	801	17	the	the	DET
fnp-3806	801	18	neuronal	neuronal	ADJ
fnp-3806	801	19	nuclei	nucleus	NOUN
fnp-3806	801	20	of	of	ADP
fnp-3806	801	21	temporal	temporal	ADJ
fnp-3806	801	22	neocortex	neocortex	NOUN
fnp-3806	801	23	in	in	ADP
fnp-3806	801	24	the	the	DET
fnp-3806	801	25	ad	ad	NOUN
fnp-3806	801	26	twin	twin	NOUN
fnp-3806	801	27	(	(	PUNCT
fnp-3806	801	28	991	991	NUM
fnp-3806	801	29	)	)	PUNCT
fnp-3806	801	30	.	.	PUNCT
fnp-3806	802	1	unfortunately	unfortunately	ADV
fnp-3806	802	2	,	,	PUNCT
fnp-3806	802	3	most	most	ADJ
fnp-3806	802	4	studies	study	NOUN
fnp-3806	802	5	are	be	AUX
fnp-3806	802	6	carried	carry	VERB
fnp-3806	802	7	out	out	ADP
fnp-3806	802	8	on	on	ADP
fnp-3806	802	9	samples	sample	NOUN
fnp-3806	802	10	at	at	ADP
fnp-3806	802	11	advanced	advanced	ADJ
fnp-3806	802	12	stages	stage	NOUN
fnp-3806	802	13	of	of	ADP
fnp-3806	802	14	sad	sad	ADJ
fnp-3806	802	15	which	which	PRON
fnp-3806	802	16	precludes	preclude	VERB
fnp-3806	802	17	learning	learn	VERB
fnp-3806	802	18	whether	whether	SCONJ
fnp-3806	802	19	epigenetic	epigenetic	ADJ
fnp-3806	802	20	changes	change	NOUN
fnp-3806	802	21	in	in	ADP
fnp-3806	802	22	dna	dna	PROPN
fnp-3806	802	23	are	be	AUX
fnp-3806	802	24	primary	primary	ADJ
fnp-3806	802	25	or	or	CCONJ
fnp-3806	802	26	secondary	secondary	ADJ
fnp-3806	802	27	events	event	NOUN
fnp-3806	802	28	(	(	PUNCT
fnp-3806	802	29	1027	1027	NUM
fnp-3806	802	30	)	)	PUNCT
fnp-3806	802	31	.	.	PUNCT
fnp-3806	803	1	in	in	ADP
fnp-3806	803	2	addition	addition	NOUN
fnp-3806	803	3	to	to	ADP
fnp-3806	803	4	modifications	modification	NOUN
fnp-3806	803	5	in	in	ADP
fnp-3806	803	6	genomic	genomic	ADJ
fnp-3806	803	7	dna	dna	NOUN
fnp-3806	803	8	,	,	PUNCT
fnp-3806	803	9	increased	increase	VERB
fnp-3806	803	10	mitochondrial	mitochondrial	ADJ
fnp-3806	803	11	5	5	NUM
fnp-3806	803	12	-	-	PUNCT
fnp-3806	803	13	methylcytosine	methylcytosine	NOUN
fnp-3806	803	14	in	in	ADP
fnp-3806	803	15	most	most	ADJ
fnp-3806	803	16	cpg	cpg	NOUN
fnp-3806	803	17	and	and	CCONJ
fnp-3806	803	18	non	non	ADJ
fnp-3806	803	19	-	-	ADJ
fnp-3806	803	20	cpg	cpg	NOUN
fnp-3806	803	21	sites	site	NOUN
fnp-3806	803	22	in	in	ADP
fnp-3806	803	23	the	the	DET
fnp-3806	803	24	d	d	PROPN
fnp-3806	803	25	-	-	PUNCT
fnp-3806	803	26	loop	loop	NOUN
fnp-3806	803	27	region	region	NOUN
fnp-3806	803	28	of	of	ADP
fnp-3806	803	29	mitochondrial	mitochondrial	ADJ
fnp-3806	803	30	dna	dna	NOUN
fnp-3806	803	31	(	(	PUNCT
fnp-3806	803	32	mtdna	mtdna	ADV
fnp-3806	803	33	)	)	PUNCT
fnp-3806	803	34	has	have	AUX
fnp-3806	803	35	been	be	AUX
fnp-3806	803	36	identified	identify	VERB
fnp-3806	803	37	in	in	ADP
fnp-3806	803	38	the	the	DET
fnp-3806	803	39	entorhinal	entorhinal	ADJ
fnp-3806	803	40	cortex	cortex	NOUN
fnp-3806	803	41	at	at	ADP
fnp-3806	803	42	nft	nft	PROPN
fnp-3806	803	43	stages	stage	NOUN
fnp-3806	803	44	i	i	PROPN
fnp-3806	803	45	-	-	PUNCT
fnp-3806	803	46	ii	ii	PROPN
fnp-3806	803	47	and	and	CCONJ
fnp-3806	803	48	iii	iii	NUM
fnp-3806	803	49	-	-	PUNCT
fnp-3806	803	50	iv	iv	NUM
fnp-3806	803	51	compared	compare	VERB
fnp-3806	803	52	with	with	ADP
fnp-3806	803	53	control	control	NOUN
fnp-3806	803	54	samples	sample	NOUN
fnp-3806	803	55	(	(	PUNCT
fnp-3806	803	56	1028	1028	NUM
fnp-3806	803	57	)	)	PUNCT
fnp-3806	803	58	.	.	PUNCT
fnp-3806	804	1	these	these	PRON
fnp-3806	804	2	are	be	AUX
fnp-3806	804	3	relevant	relevant	ADJ
fnp-3806	804	4	data	datum	NOUN
fnp-3806	804	5	as	as	SCONJ
fnp-3806	804	6	they	they	PRON
fnp-3806	804	7	indicate	indicate	VERB
fnp-3806	804	8	early	early	ADJ
fnp-3806	804	9	mtdna	mtdna	NOUN
fnp-3806	804	10	methylation	methylation	NOUN
fnp-3806	804	11	linked	link	VERB
fnp-3806	804	12	to	to	ADP
fnp-3806	804	13	the	the	DET
fnp-3806	804	14	pathogenesis	pathogenesis	NOUN
fnp-3806	804	15	of	of	ADP
fnp-3806	804	16	ad	ad	NOUN
fnp-3806	804	17	-	-	PUNCT
fnp-3806	804	18	related	relate	VERB
fnp-3806	804	19	neuropathologic	neuropathologic	ADJ
fnp-3806	804	20	change	change	NOUN
fnp-3806	804	21	(	(	PUNCT
fnp-3806	804	22	1028	1028	NUM
fnp-3806	804	23	)	)	PUNCT
fnp-3806	804	24	.	.	PUNCT
fnp-3806	805	1	15b	15b	NOUN
fnp-3806	805	2	.	.	PUNCT
fnp-3806	806	1	non	non	ADJ
fnp-3806	806	2	-	-	ADJ
fnp-3806	806	3	coding	coding	ADJ
fnp-3806	806	4	rnas	rna	NOUN
fnp-3806	806	5	non	non	ADJ
fnp-3806	806	6	-	-	ADJ
fnp-3806	806	7	coding	coding	ADJ
fnp-3806	806	8	rnas	rna	NOUN
fnp-3806	806	9	do	do	AUX
fnp-3806	806	10	not	not	PART
fnp-3806	806	11	encode	encode	VERB
fnp-3806	806	12	proteins	protein	NOUN
fnp-3806	806	13	,	,	PUNCT
fnp-3806	806	14	but	but	CCONJ
fnp-3806	806	15	most	most	ADJ
fnp-3806	806	16	modulate	modulate	VERB
fnp-3806	806	17	protein	protein	NOUN
fnp-3806	806	18	translation	translation	NOUN
fnp-3806	806	19	targeting	target	VERB
fnp-3806	806	20	mrnas	mrna	NOUN
fnp-3806	806	21	.	.	PUNCT
fnp-3806	807	1	transfer	transfer	VERB
fnp-3806	807	2	rnas	rna	NOUN
fnp-3806	807	3	(	(	PUNCT
fnp-3806	807	4	trnas	trnas	NOUN
fnp-3806	807	5	)	)	PUNCT
fnp-3806	807	6	and	and	CCONJ
fnp-3806	807	7	ribosomal	ribosomal	NOUN
fnp-3806	807	8	rnas	rna	NOUN
fnp-3806	807	9	(	(	PUNCT
fnp-3806	807	10	rrnas	rrnas	PROPN
fnp-3806	807	11	)	)	PUNCT
fnp-3806	807	12	;	;	PUNCT
fnp-3806	807	13	small	small	ADJ
fnp-3806	807	14	non	non	ADJ
fnp-3806	807	15	-	-	ADJ
fnp-3806	807	16	coding	coding	ADJ
fnp-3806	807	17	(	(	PUNCT
fnp-3806	807	18	snrnas	snrna	NOUN
fnp-3806	807	19	)	)	PUNCT
fnp-3806	807	20	such	such	ADJ
fnp-3806	807	21	as	as	ADP
fnp-3806	807	22	micrornas	microrna	NOUN
fnp-3806	807	23	(	(	PUNCT
fnp-3806	807	24	mirnas	mirna	NOUN
fnp-3806	807	25	)	)	PUNCT
fnp-3806	807	26	,	,	PUNCT
fnp-3806	807	27	small	small	ADJ
fnp-3806	807	28	interfering	interfere	VERB
fnp-3806	807	29	rnas	rna	NOUN
fnp-3806	807	30	(	(	PUNCT
fnp-3806	807	31	sirnas	sirnas	PROPN
fnp-3806	807	32	)	)	PUNCT
fnp-3806	807	33	,	,	PUNCT
fnp-3806	807	34	piwi	piwi	NOUN
fnp-3806	807	35	-	-	PUNCT
fnp-3806	807	36	interacting	interact	VERB
fnp-3806	807	37	rnas	rna	NOUN
fnp-3806	807	38	(	(	PUNCT
fnp-3806	807	39	pirnas	pirnas	PROPN
fnp-3806	807	40	)	)	PUNCT
fnp-3806	807	41	,	,	PUNCT
fnp-3806	807	42	small	small	ADJ
fnp-3806	807	43	nuclear	nuclear	ADJ
fnp-3806	807	44	rnas	rna	NOUN
fnp-3806	807	45	(	(	PUNCT
fnp-3806	807	46	snrnas	snrnas	NOUN
fnp-3806	807	47	)	)	PUNCT
fnp-3806	807	48	,	,	PUNCT
fnp-3806	807	49	small	small	ADJ
fnp-3806	807	50	nucleolar	nucleolar	ADJ
fnp-3806	807	51	rnas	rna	NOUN
fnp-3806	807	52	(	(	PUNCT
fnp-3806	807	53	snornas	snornas	PROPN
fnp-3806	807	54	)	)	PUNCT
fnp-3806	807	55	,	,	PUNCT
fnp-3806	807	56	extracellular	extracellular	ADJ
fnp-3806	807	57	rnas	rna	NOUN
fnp-3806	807	58	(	(	PUNCT
fnp-3806	807	59	exrnas	exrnas	PROPN
fnp-3806	807	60	)	)	PUNCT
fnp-3806	807	61	,	,	PUNCT
fnp-3806	807	62	small	small	ADJ
fnp-3806	807	63	cajal	cajal	ADJ
fnp-3806	807	64	-	-	PUNCT
fnp-3806	807	65	body	body	NOUN
fnp-3806	807	66	specific	specific	ADJ
fnp-3806	807	67	rnas	rna	NOUN
fnp-3806	807	68	(	(	PUNCT
fnp-3806	807	69	scarnas	scarna	NOUN
fnp-3806	807	70	)	)	PUNCT
fnp-3806	807	71	;	;	PUNCT
fnp-3806	807	72	and	and	CCONJ
fnp-3806	807	73	long	long	ADJ
fnp-3806	807	74	non	non	ADJ
fnp-3806	807	75	-	-	ADJ
fnp-3806	807	76	coding	coding	ADJ
fnp-3806	807	77	rnas	rna	NOUN
fnp-3806	807	78	(	(	PUNCT
fnp-3806	807	79	lncrnas	lncrna	NOUN
fnp-3806	807	80	)	)	PUNCT
fnp-3806	807	81	are	be	AUX
fnp-3806	807	82	the	the	DET
fnp-3806	807	83	principal	principal	ADJ
fnp-3806	807	84	types	type	NOUN
fnp-3806	807	85	.	.	PUNCT
fnp-3806	808	1	mirnas	mirna	NOUN
fnp-3806	808	2	bind	bind	VERB
fnp-3806	808	3	to	to	ADP
fnp-3806	808	4	complementary	complementary	ADJ
fnp-3806	808	5	un	un	ADJ
fnp-3806	808	6	-	-	ADJ
fnp-3806	808	7	translated	translate	VERB
fnp-3806	808	8	regions	region	NOUN
fnp-3806	808	9	(	(	PUNCT
fnp-3806	808	10	3’-utrs	3’-utrs	NUM
fnp-3806	808	11	)	)	PUNCT
fnp-3806	808	12	of	of	ADP
fnp-3806	808	13	mrnas	mrna	NOUN
fnp-3806	808	14	to	to	PART
fnp-3806	808	15	regulate	regulate	VERB
fnp-3806	808	16	target	target	NOUN
fnp-3806	808	17	genes	gene	NOUN
fnp-3806	808	18	,	,	PUNCT
fnp-3806	808	19	resulting	result	VERB
fnp-3806	808	20	in	in	ADP
fnp-3806	808	21	translational	translational	ADJ
fnp-3806	808	22	repression	repression	NOUN
fnp-3806	808	23	or	or	CCONJ
fnp-3806	808	24	degradation	degradation	NOUN
fnp-3806	808	25	(	(	PUNCT
fnp-3806	808	26	1029	1029	NUM
fnp-3806	808	27	-	-	SYM
fnp-3806	808	28	1031	1031	NUM
fnp-3806	808	29	)	)	PUNCT
fnp-3806	808	30	.	.	PUNCT
fnp-3806	809	1	in	in	ADP
fnp-3806	809	2	animals	animal	NOUN
fnp-3806	809	3	,	,	PUNCT
fnp-3806	809	4	mirnas	mirna	NOUN
fnp-3806	809	5	are	be	AUX
fnp-3806	809	6	synthesized	synthesize	VERB
fnp-3806	809	7	from	from	ADP
fnp-3806	809	8	primary	primary	ADJ
fnp-3806	809	9	mirnas	mirna	NOUN
fnp-3806	809	10	by	by	ADP
fnp-3806	809	11	the	the	DET
fnp-3806	809	12	action	action	NOUN
fnp-3806	809	13	of	of	ADP
fnp-3806	809	14	two	two	NUM
fnp-3806	809	15	rnase	rnase	PROPN
fnp-3806	809	16	iii	iii	NOUN
fnp-3806	809	17	-	-	PUNCT
fnp-3806	809	18	type	type	NOUN
fnp-3806	809	19	proteins	protein	NOUN
fnp-3806	809	20	:	:	PUNCT
fnp-3806	809	21	drosha	drosha	ADJ
fnp-3806	809	22	,	,	PUNCT
fnp-3806	809	23	in	in	ADP
fnp-3806	809	24	the	the	DET
fnp-3806	809	25	nucleus	nucleus	NOUN
fnp-3806	809	26	,	,	PUNCT
fnp-3806	809	27	and	and	CCONJ
fnp-3806	809	28	dicer	dicer	NOUN
fnp-3806	809	29	in	in	ADP
fnp-3806	809	30	the	the	DET
fnp-3806	809	31	cytoplasm	cytoplasm	NOUN
fnp-3806	809	32	.	.	PROPN
fnp-3806	810	1	argonaute	argonaute	PROPN
fnp-3806	810	2	(	(	PUNCT
fnp-3806	810	3	ago	ago	ADV
fnp-3806	810	4	)	)	PUNCT
fnp-3806	810	5	subfamily	subfamily	ADV
fnp-3806	810	6	proteins	protein	NOUN
fnp-3806	810	7	bind	bind	VERB
fnp-3806	810	8	mature	mature	ADJ
fnp-3806	810	9	mirnas	mirna	NOUN
fnp-3806	810	10	to	to	PART
fnp-3806	810	11	target	target	VERB
fnp-3806	810	12	mrnas	mrna	NOUN
fnp-3806	810	13	(	(	PUNCT
fnp-3806	810	14	1032	1032	NUM
fnp-3806	810	15	,	,	PUNCT
fnp-3806	810	16	1033	1033	NUM
fnp-3806	810	17	)	)	PUNCT
fnp-3806	810	18	.	.	PUNCT
fnp-3806	811	1	thousands	thousand	NOUN
fnp-3806	811	2	of	of	ADP
fnp-3806	811	3	human	human	ADJ
fnp-3806	811	4	genes	gene	NOUN
fnp-3806	811	5	are	be	AUX
fnp-3806	811	6	mirna	mirna	NOUN
fnp-3806	811	7	targets	target	NOUN
fnp-3806	811	8	(	(	PUNCT
fnp-3806	811	9	1034	1034	NUM
fnp-3806	811	10	,	,	PUNCT
fnp-3806	811	11	1035	1035	NUM
fnp-3806	811	12	)	)	PUNCT
fnp-3806	811	13	.	.	PUNCT
fnp-3806	812	1	ago2	ago2	NOUN
fnp-3806	812	2	:	:	PUNCT
fnp-3806	813	1	rna	rna	NOUN
fnp-3806	813	2	interactions	interaction	NOUN
fnp-3806	813	3	using	use	VERB
fnp-3806	813	4	hits	hit	NOUN
fnp-3806	813	5	-	-	PUNCT
fnp-3806	813	6	clip	clip	NOUN
fnp-3806	813	7	have	have	AUX
fnp-3806	813	8	been	be	AUX
fnp-3806	813	9	used	use	VERB
fnp-3806	813	10	to	to	PART
fnp-3806	813	11	generate	generate	VERB
fnp-3806	813	12	a	a	DET
fnp-3806	813	13	transcriptome	transcriptome	ADJ
fnp-3806	813	14	-	-	PUNCT
fnp-3806	813	15	wide	wide	ADJ
fnp-3806	813	16	map	map	NOUN
fnp-3806	813	17	of	of	ADP
fnp-3806	813	18	mirna	mirna	NOUN
fnp-3806	813	19	binding	bind	VERB
fnp-3806	813	20	sites	site	NOUN
fnp-3806	813	21	in	in	ADP
fnp-3806	813	22	the	the	DET
fnp-3806	813	23	human	human	ADJ
fnp-3806	813	24	brain	brain	NOUN
fnp-3806	813	25	.	.	PUNCT
fnp-3806	814	1	about	about	ADV
fnp-3806	814	2	7,000	7,000	NUM
fnp-3806	814	3	stringent	stringent	ADJ
fnp-3806	814	4	ago2	ago2	NOUN
fnp-3806	814	5	binding	bind	VERB
fnp-3806	814	6	sites	site	NOUN
fnp-3806	814	7	were	be	AUX
fnp-3806	814	8	highly	highly	ADV
fnp-3806	814	9	enriched	enrich	VERB
fnp-3806	814	10	for	for	ADP
fnp-3806	814	11	conserved	conserve	VERB
fnp-3806	814	12	sequences	sequence	NOUN
fnp-3806	814	13	corresponding	correspond	VERB
fnp-3806	814	14	to	to	ADP
fnp-3806	814	15	abundant	abundant	ADJ
fnp-3806	814	16	brain	brain	NOUN
fnp-3806	814	17	mirnas	mirna	NOUN
fnp-3806	814	18	.	.	PUNCT
fnp-3806	815	1	this	this	DET
fnp-3806	815	2	interactome	interactome	NOUN
fnp-3806	815	3	points	point	VERB
fnp-3806	815	4	to	to	ADP
fnp-3806	815	5	functional	functional	ADJ
fnp-3806	815	6	mirna	mirna	NOUN
fnp-3806	815	7	:	:	PUNCT
fnp-3806	815	8	target	target	VERB
fnp-3806	815	9	pairs	pair	NOUN
fnp-3806	815	10	across	across	ADP
fnp-3806	815	11	about	about	ADP
fnp-3806	815	12	3,000	3,000	NUM
fnp-3806	815	13	genes	gene	NOUN
fnp-3806	815	14	(	(	PUNCT
fnp-3806	815	15	1036	1036	NUM
fnp-3806	815	16	)	)	PUNCT
fnp-3806	815	17	.	.	PUNCT
fnp-3806	816	1	dysregulation	dysregulation	NOUN
fnp-3806	816	2	of	of	ADP
fnp-3806	816	3	mirnas	mirna	NOUN
fnp-3806	816	4	is	be	AUX
fnp-3806	816	5	involved	involve	VERB
fnp-3806	816	6	in	in	ADP
fnp-3806	816	7	the	the	DET
fnp-3806	816	8	pathogenesis	pathogenesis	NOUN
fnp-3806	816	9	of	of	ADP
fnp-3806	816	10	sad	sad	ADJ
fnp-3806	816	11	(	(	PUNCT
fnp-3806	816	12	1037	1037	NUM
fnp-3806	816	13	-	-	SYM
fnp-3806	816	14	1040	1040	NUM
fnp-3806	816	15	)	)	PUNCT
fnp-3806	816	16	.	.	PUNCT
fnp-3806	817	1	several	several	ADJ
fnp-3806	817	2	mirnas	mirna	NOUN
fnp-3806	817	3	target	target	NOUN
fnp-3806	817	4	genes	gene	NOUN
fnp-3806	817	5	,	,	PUNCT
fnp-3806	817	6	many	many	ADJ
fnp-3806	817	7	of	of	ADP
fnp-3806	817	8	them	they	PRON
fnp-3806	817	9	abnormally	abnormally	ADV
fnp-3806	817	10	regulated	regulate	VERB
fnp-3806	817	11	in	in	ADP
fnp-3806	817	12	ad	ad	NOUN
fnp-3806	817	13	,	,	PUNCT
fnp-3806	817	14	are	be	AUX
fnp-3806	817	15	associated	associate	VERB
fnp-3806	817	16	with	with	ADP
fnp-3806	817	17	β	β	NOUN
fnp-3806	817	18	-	-	NOUN
fnp-3806	817	19	amyloid	amyloid	NOUN
fnp-3806	817	20	(	(	PUNCT
fnp-3806	817	21	1041	1041	NUM
fnp-3806	817	22	-	-	SYM
fnp-3806	817	23	1060	1060	NUM
fnp-3806	817	24	)	)	PUNCT
fnp-3806	817	25	,	,	PUNCT
fnp-3806	817	26	tau	tau	PROPN
fnp-3806	817	27	phosphorylation	phosphorylation	NOUN
fnp-3806	817	28	,	,	PUNCT
fnp-3806	817	29	and	and	CCONJ
fnp-3806	817	30	cytoskeleton	cytoskeleton	PROPN
fnp-3806	817	31	(	(	PUNCT
fnp-3806	817	32	1061	1061	NUM
fnp-3806	817	33	-	-	SYM
fnp-3806	817	34	1074	1074	NUM
fnp-3806	817	35	)	)	PUNCT
fnp-3806	817	36	.	.	PUNCT
fnp-3806	818	1	it	it	PRON
fnp-3806	818	2	is	be	AUX
fnp-3806	818	3	difficult	difficult	ADJ
fnp-3806	818	4	to	to	PART
fnp-3806	818	5	ascertain	ascertain	VERB
fnp-3806	818	6	which	which	PRON
fnp-3806	818	7	mirna	mirna	PROPN
fnp-3806	818	8	alterations	alteration	NOUN
fnp-3806	818	9	are	be	AUX
fnp-3806	818	10	primarily	primarily	ADV
fnp-3806	818	11	altered	alter	VERB
fnp-3806	818	12	or	or	CCONJ
fnp-3806	818	13	secondary	secondary	ADJ
fnp-3806	818	14	to	to	ADP
fnp-3806	818	15	β	β	NOUN
fnp-3806	818	16	-	-	NOUN
fnp-3806	818	17	amyloid	amyloid	NOUN
fnp-3806	818	18	and	and	CCONJ
fnp-3806	818	19	tau	tau	PROPN
fnp-3806	818	20	pathology	pathology	NOUN
fnp-3806	818	21	in	in	ADP
fnp-3806	818	22	sad	sad	ADJ
fnp-3806	818	23	(	(	PUNCT
fnp-3806	818	24	1075	1075	NUM
fnp-3806	818	25	)	)	PUNCT
fnp-3806	818	26	.	.	PUNCT
fnp-3806	819	1	several	several	ADJ
fnp-3806	819	2	mirnas	mirna	NOUN
fnp-3806	819	3	can	can	AUX
fnp-3806	819	4	bind	bind	VERB
fnp-3806	819	5	to	to	ADP
fnp-3806	819	6	specific	specific	ADJ
fnp-3806	819	7	mrnas	mrna	NOUN
fnp-3806	819	8	,	,	PUNCT
fnp-3806	819	9	modulating	modulate	VERB
fnp-3806	819	10	gene	gene	NOUN
fnp-3806	819	11	transcription	transcription	NOUN
fnp-3806	819	12	differentially	differentially	ADV
fnp-3806	819	13	depending	depend	VERB
fnp-3806	819	14	on	on	ADP
fnp-3806	819	15	the	the	DET
fnp-3806	819	16	triggering	trigger	VERB
fnp-3806	819	17	factor	factor	NOUN
fnp-3806	819	18	(	(	PUNCT
fnp-3806	819	19	1038	1038	NUM
fnp-3806	819	20	)	)	PUNCT
fnp-3806	819	21	.	.	PUNCT
fnp-3806	820	1	mirna	mirna	PROPN
fnp-3806	820	2	163	163	NUM
fnp-3806	820	3	,	,	PUNCT
fnp-3806	820	4	mirna30a	mirna30a	NOUN
fnp-3806	820	5	5p	5p	NUM
fnp-3806	820	6	,	,	PUNCT
fnp-3806	820	7	and	and	CCONJ
fnp-3806	820	8	mirna206	mirna206	PROPN
fnp-3806	820	9	bind	bind	VERB
fnp-3806	820	10	to	to	ADP
fnp-3806	820	11	bdnf	bdnf	PROPN
fnp-3806	820	12	mrna	mrna	PROPN
fnp-3806	820	13	and	and	CCONJ
fnp-3806	820	14	modulate	modulate	VERB
fnp-3806	820	15	altered	alter	VERB
fnp-3806	820	16	bdnf	bdnf	ADJ
fnp-3806	820	17	expression	expression	NOUN
fnp-3806	820	18	in	in	ADP
fnp-3806	820	19	sad	sad	ADJ
fnp-3806	820	20	(	(	PUNCT
fnp-3806	820	21	1040	1040	NUM
fnp-3806	820	22	,	,	PUNCT
fnp-3806	820	23	1055	1055	NUM
fnp-3806	820	24	,	,	PUNCT
fnp-3806	820	25	1076	1076	NUM
fnp-3806	820	26	)	)	PUNCT
fnp-3806	820	27	.	.	PUNCT
fnp-3806	821	1	furthermore	furthermore	ADV
fnp-3806	821	2	,	,	PUNCT
fnp-3806	821	3	one	one	NUM
fnp-3806	821	4	mirna	mirna	NOUN
fnp-3806	821	5	can	can	AUX
fnp-3806	821	6	bind	bind	VERB
fnp-3806	821	7	to	to	ADP
fnp-3806	821	8	different	different	ADJ
fnp-3806	821	9	mrnas	mrna	NOUN
fnp-3806	821	10	resulting	result	VERB
fnp-3806	821	11	in	in	ADP
fnp-3806	821	12	various	various	ADJ
fnp-3806	821	13	functions	function	NOUN
fnp-3806	821	14	.	.	PUNCT
fnp-3806	822	1	for	for	ADP
fnp-3806	822	2	example	example	NOUN
fnp-3806	822	3	,	,	PUNCT
fnp-3806	822	4	reduced	reduce	VERB
fnp-3806	822	5	mirna	mirna	PROPN
fnp-3806	822	6	132	132	NUM
fnp-3806	822	7	is	be	AUX
fnp-3806	822	8	associated	associate	VERB
fnp-3806	822	9	with	with	ADP
fnp-3806	822	10	downregulation	downregulation	NOUN
fnp-3806	822	11	of	of	ADP
fnp-3806	822	12	chat	chat	NOUN
fnp-3806	822	13	immunoreactivity	immunoreactivity	NOUN
fnp-3806	822	14	in	in	ADP
fnp-3806	822	15	the	the	DET
fnp-3806	822	16	nucleus	nucleus	ADJ
fnp-3806	822	17	basalis	basali	NOUN
fnp-3806	822	18	of	of	ADP
fnp-3806	822	19	meynert	meynert	PROPN
fnp-3806	822	20	(	(	PUNCT
fnp-3806	822	21	1061	1061	NUM
fnp-3806	822	22	)	)	PUNCT
fnp-3806	822	23	and	and	CCONJ
fnp-3806	822	24	to	to	PART
fnp-3806	822	25	ache	ache	PROPN
fnp-3806	822	26	upregulation	upregulation	NOUN
fnp-3806	822	27	(	(	PUNCT
fnp-3806	822	28	1077	1077	NUM
fnp-3806	822	29	,	,	PUNCT
fnp-3806	822	30	1078	1078	NUM
fnp-3806	822	31	)	)	PUNCT
fnp-3806	822	32	.	.	PUNCT
fnp-3806	823	1	in	in	ADP
fnp-3806	823	2	addition	addition	NOUN
fnp-3806	823	3	,	,	PUNCT
fnp-3806	823	4	mirna	mirna	NOUN
fnp-3806	823	5	132	132	NUM
fnp-3806	823	6	targets	target	NOUN
fnp-3806	823	7	creb	creb	NOUN
fnp-3806	823	8	and	and	CCONJ
fnp-3806	823	9	promotes	promote	VERB
fnp-3806	823	10	neuritogenesis	neuritogenesis	ADV
fnp-3806	823	11	and	and	CCONJ
fnp-3806	823	12	synaptic	synaptic	ADJ
fnp-3806	823	13	activity	activity	NOUN
fnp-3806	823	14	(	(	PUNCT
fnp-3806	823	15	1079	1079	NUM
fnp-3806	823	16	)	)	PUNCT
fnp-3806	823	17	.	.	PUNCT
fnp-3806	824	1	finally	finally	ADV
fnp-3806	824	2	,	,	PUNCT
fnp-3806	824	3	mirna	mirna	PROPN
fnp-3806	824	4	dysregulation	dysregulation	PROPN
fnp-3806	824	5	is	be	AUX
fnp-3806	824	6	stageand	stageand	NOUN
fnp-3806	824	7	region	region	NOUN
fnp-3806	824	8	-	-	PUNCT
fnp-3806	824	9	dependent	dependent	ADJ
fnp-3806	824	10	.	.	PUNCT
fnp-3806	825	1	for	for	ADP
fnp-3806	825	2	example	example	NOUN
fnp-3806	825	3	,	,	PUNCT
fnp-3806	825	4	in	in	ADP
fnp-3806	825	5	the	the	DET
fnp-3806	825	6	locus	locus	NOUN
fnp-3806	825	7	coeruleus	coeruleus	NOUN
fnp-3806	825	8	,	,	PUNCT
fnp-3806	825	9	mirna-27a-3p	mirna-27a-3p	PROPN
fnp-3806	825	10	,	,	PUNCT
fnp-3806	825	11	mirna-124	mirna-124	NOUN
fnp-3806	825	12	-	-	PUNCT
fnp-3806	825	13	3p	3p	NUM
fnp-3806	825	14	,	,	PUNCT
fnp-3806	825	15	and	and	CCONJ
fnp-3806	825	16	mirna-143	mirna-143	NOUN
fnp-3806	825	17	-	-	PUNCT
fnp-3806	825	18	3p	3p	NUM
fnp-3806	825	19	show	show	VERB
fnp-3806	825	20	a	a	DET
fnp-3806	825	21	trend	trend	NOUN
fnp-3806	825	22	to	to	PART
fnp-3806	825	23	increase	increase	VERB
fnp-3806	825	24	at	at	ADP
fnp-3806	825	25	nft	nft	PROPN
fnp-3806	825	26	stages	stage	NOUN
fnp-3806	825	27	i	i	PROPN
fnp-3806	825	28	-	-	PUNCT
fnp-3806	825	29	ii	ii	PROPN
fnp-3806	825	30	and	and	CCONJ
fnp-3806	825	31	are	be	AUX
fnp-3806	825	32	significantly	significantly	ADV
fnp-3806	825	33	upregulated	upregulate	VERB
fnp-3806	825	34	at	at	ADP
fnp-3806	825	35	nft	nft	PROPN
fnp-3806	825	36	stages	stages	PROPN
fnp-3806	825	37	iii	iii	PROPN
fnp-3806	825	38	-	-	PUNCT
fnp-3806	825	39	iv	iv	NOUN
fnp-3806	825	40	when	when	SCONJ
fnp-3806	825	41	compared	compare	VERB
fnp-3806	825	42	with	with	ADP
fnp-3806	825	43	ma	ma	PROPN
fnp-3806	825	44	individuals	individual	NOUN
fnp-3806	825	45	without	without	ADP
fnp-3806	825	46	nft	nft	PROPN
fnp-3806	825	47	pathology	pathology	PROPN
fnp-3806	825	48	.	.	PUNCT
fnp-3806	826	1	in	in	ADP
fnp-3806	826	2	the	the	DET
fnp-3806	826	3	entorhinal	entorhinal	ADJ
fnp-3806	826	4	cortex	cortex	NOUN
fnp-3806	826	5	of	of	ADP
fnp-3806	826	6	the	the	DET
fnp-3806	826	7	same	same	ADJ
fnp-3806	826	8	cases	case	NOUN
fnp-3806	826	9	,	,	PUNCT
fnp-3806	826	10	only	only	ADV
fnp-3806	826	11	mirna-143	mirna-143	NOUN
fnp-3806	826	12	-	-	PUNCT
fnp-3806	826	13	3p	3p	NUM
fnp-3806	826	14	is	be	AUX
fnp-3806	826	15	upregulated	upregulate	VERB
fnp-3806	826	16	at	at	ADP
fnp-3806	826	17	stages	stage	NOUN
fnp-3806	826	18	iii	iii	NOUN
fnp-3806	826	19	-	-	PUNCT
fnp-3806	826	20	iv	iv	NOUN
fnp-3806	826	21	.	.	PUNCT
fnp-3806	827	1	the	the	DET
fnp-3806	827	2	expression	expression	NOUN
fnp-3806	827	3	levels	level	NOUN
fnp-3806	827	4	of	of	ADP
fnp-3806	827	5	mirna-27a-3p	mirna-27a-3p	PROPN
fnp-3806	827	6	,	,	PUNCT
fnp-3806	827	7	mirna-124	mirna-124	NOUN
fnp-3806	827	8	-	-	PUNCT
fnp-3806	827	9	3p	3p	NUM
fnp-3806	827	10	,	,	PUNCT
fnp-3806	827	11	and	and	CCONJ
fnp-3806	827	12	mirna-143	mirna-143	NOUN
fnp-3806	827	13	-	-	PUNCT
fnp-3806	827	14	3p	3p	NUM
fnp-3806	827	15	are	be	AUX
fnp-3806	827	16	not	not	PART
fnp-3806	827	17	modified	modify	VERB
fnp-3806	827	18	in	in	ADP
fnp-3806	827	19	ca1	ca1	PROPN
fnp-3806	827	20	at	at	ADP
fnp-3806	827	21	any	any	DET
fnp-3806	827	22	stage	stage	NOUN
fnp-3806	827	23	,	,	PUNCT
fnp-3806	827	24	whereas	whereas	SCONJ
fnp-3806	827	25	mirna-124	mirna-124	ADJ
fnp-3806	827	26	-	-	PUNCT
fnp-3806	827	27	3p	3p	NUM
fnp-3806	827	28	is	be	AUX
fnp-3806	827	29	significantly	significantly	ADV
fnp-3806	827	30	downregulated	downregulate	VERB
fnp-3806	827	31	in	in	ADP
fnp-3806	827	32	the	the	DET
fnp-3806	827	33	dentate	dentate	ADJ
fnp-3806	827	34	gyrus	gyrus	NOUN
fnp-3806	827	35	at	at	ADP
fnp-3806	827	36	nft	nft	PROPN
fnp-3806	827	37	stages	stage	NOUN
fnp-3806	827	38	i	i	PROPN
fnp-3806	827	39	-	-	PUNCT
fnp-3806	827	40	ii	ii	PROPN
fnp-3806	827	41	(	(	PUNCT
fnp-3806	827	42	1080	1080	NUM
fnp-3806	827	43	)	)	PUNCT
fnp-3806	827	44	.	.	PUNCT
fnp-3806	828	1	the	the	DET
fnp-3806	828	2	interpretation	interpretation	NOUN
fnp-3806	828	3	of	of	ADP
fnp-3806	828	4	these	these	DET
fnp-3806	828	5	results	result	NOUN
fnp-3806	828	6	is	be	AUX
fnp-3806	828	7	puzzling	puzzle	VERB
fnp-3806	828	8	:	:	PUNCT
fnp-3806	828	9	downregulation	downregulation	NOUN
fnp-3806	828	10	of	of	ADP
fnp-3806	828	11	mirna124	mirna124	PROPN
fnp-3806	828	12	results	result	NOUN
fnp-3806	828	13	in	in	ADP
fnp-3806	828	14	β	β	ADJ
fnp-3806	828	15	-	-	ADJ
fnp-3806	828	16	amyloid	amyloid	ADJ
fnp-3806	828	17	accumulation	accumulation	NOUN
fnp-3806	828	18	(	(	PUNCT
fnp-3806	828	19	1007	1007	NUM
fnp-3806	828	20	)	)	PUNCT
fnp-3806	828	21	;	;	PUNCT
fnp-3806	828	22	mirna143	mirna143	PROPN
fnp-3806	828	23	-	-	PUNCT
fnp-3806	828	24	3p	3p	NUM
fnp-3806	828	25	inhibition	inhibition	NOUN
fnp-3806	828	26	promotes	promote	VERB
fnp-3806	828	27	neuronal	neuronal	ADJ
fnp-3806	828	28	survival	survival	NOUN
fnp-3806	828	29	in	in	ADP
fnp-3806	828	30	sad	sad	ADJ
fnp-3806	828	31	(	(	PUNCT
fnp-3806	828	32	1081	1081	NUM
fnp-3806	828	33	)	)	PUNCT
fnp-3806	828	34	;	;	PUNCT
fnp-3806	828	35	and	and	CCONJ
fnp-3806	828	36	mirna	mirna	PROPN
fnp-3806	828	37	27a-3p	27a-3p	NUM
fnp-3806	828	38	regulates	regulate	VERB
fnp-3806	828	39	the	the	DET
fnp-3806	828	40	expression	expression	NOUN
fnp-3806	828	41	of	of	ADP
fnp-3806	828	42	intercellular	intercellular	ADJ
fnp-3806	828	43	junction	junction	NOUN
fnp-3806	828	44	proteins	protein	NOUN
fnp-3806	828	45	at	at	ADP
fnp-3806	828	46	the	the	DET
fnp-3806	828	47	brain	brain	NOUN
fnp-3806	828	48	endothelium	endothelium	NOUN
fnp-3806	828	49	,	,	PUNCT
fnp-3806	828	50	while	while	SCONJ
fnp-3806	828	51	its	its	PRON
fnp-3806	828	52	downregulation	downregulation	NOUN
fnp-3806	828	53	increases	increase	VERB
fnp-3806	828	54	bbb	bbb	NOUN
fnp-3806	828	55	permeability	permeability	NOUN
fnp-3806	828	56	(	(	PUNCT
fnp-3806	828	57	1082	1082	NUM
fnp-3806	828	58	,	,	PUNCT
fnp-3806	828	59	1083	1083	NUM
fnp-3806	828	60	)	)	PUNCT
fnp-3806	828	61	.	.	PUNCT
fnp-3806	829	1	16	16	NUM
fnp-3806	829	2	.	.	PUNCT
fnp-3806	829	3	microorganisms	microorganism	NOUN
fnp-3806	829	4	and	and	CCONJ
fnp-3806	829	5	sad	sad	ADJ
fnp-3806	829	6	the	the	DET
fnp-3806	829	7	possibility	possibility	NOUN
fnp-3806	829	8	that	that	SCONJ
fnp-3806	829	9	microorganisms	microorganism	NOUN
fnp-3806	829	10	participate	participate	VERB
fnp-3806	829	11	in	in	ADP
fnp-3806	829	12	the	the	DET
fnp-3806	829	13	pathogenesis	pathogenesis	NOUN
fnp-3806	829	14	of	of	ADP
fnp-3806	829	15	ad	ad	NOUN
fnp-3806	829	16	was	be	AUX
fnp-3806	829	17	suggested	suggest	VERB
fnp-3806	829	18	in	in	ADP
fnp-3806	829	19	a	a	DET
fnp-3806	829	20	seminal	seminal	ADJ
fnp-3806	829	21	publication	publication	NOUN
fnp-3806	829	22	in	in	ADP
fnp-3806	829	23	1907	1907	NUM
fnp-3806	829	24	(	(	PUNCT
fnp-3806	829	25	1084	1084	NUM
fnp-3806	829	26	)	)	PUNCT
fnp-3806	829	27	.	.	PUNCT
fnp-3806	830	1	the	the	DET
fnp-3806	830	2	role	role	NOUN
fnp-3806	830	3	of	of	ADP
fnp-3806	830	4	bacteria	bacteria	NOUN
fnp-3806	830	5	,	,	PUNCT
fnp-3806	830	6	viruses	virus	NOUN
fnp-3806	830	7	,	,	PUNCT
fnp-3806	830	8	and	and	CCONJ
fnp-3806	830	9	fungi	fungus	NOUN
fnp-3806	830	10	has	have	AUX
fnp-3806	830	11	been	be	AUX
fnp-3806	830	12	proposed	propose	VERB
fnp-3806	830	13	to	to	ADP
fnp-3806	830	14	the	the	DET
fnp-3806	830	15	present	present	ADJ
fnp-3806	830	16	(	(	PUNCT
fnp-3806	830	17	1085	1085	NUM
fnp-3806	830	18	-	-	SYM
fnp-3806	830	19	1088	1088	NUM
fnp-3806	830	20	)	)	PUNCT
fnp-3806	830	21	.	.	PUNCT
fnp-3806	831	1	16a	16a	NOUN
fnp-3806	831	2	.	.	PUNCT
fnp-3806	832	1	microorganisms	microorganism	NOUN
fnp-3806	832	2	in	in	ADP
fnp-3806	832	3	the	the	DET
fnp-3806	832	4	brain	brain	NOUN
fnp-3806	832	5	and	and	CCONJ
fnp-3806	832	6	oral	oral	ADJ
fnp-3806	832	7	cavity	cavity	NOUN
fnp-3806	832	8	more	more	ADJ
fnp-3806	832	9	than	than	ADP
fnp-3806	832	10	thirty	thirty	NUM
fnp-3806	832	11	years	year	NOUN
fnp-3806	832	12	ago	ago	ADV
fnp-3806	832	13	,	,	PUNCT
fnp-3806	832	14	borrelia	borrelia	X
fnp-3806	832	15	burgdorferi	burgdorferi	NOUN
fnp-3806	832	16	was	be	AUX
fnp-3806	832	17	reported	report	VERB
fnp-3806	832	18	in	in	ADP
fnp-3806	832	19	the	the	DET
fnp-3806	832	20	brains	brain	NOUN
fnp-3806	832	21	of	of	ADP
fnp-3806	832	22	sad	sad	ADJ
fnp-3806	832	23	cases	case	NOUN
fnp-3806	832	24	(	(	PUNCT
fnp-3806	832	25	1089	1089	NUM
fnp-3806	832	26	)	)	PUNCT
fnp-3806	832	27	,	,	PUNCT
fnp-3806	832	28	although	although	SCONJ
fnp-3806	832	29	other	other	ADJ
fnp-3806	832	30	studies	study	NOUN
fnp-3806	832	31	did	do	AUX
fnp-3806	832	32	not	not	PART
fnp-3806	832	33	validate	validate	VERB
fnp-3806	832	34	this	this	DET
fnp-3806	832	35	finding	finding	NOUN
fnp-3806	832	36	(	(	PUNCT
fnp-3806	832	37	1090	1090	NUM
fnp-3806	832	38	)	)	PUNCT
fnp-3806	832	39	.	.	PUNCT
fnp-3806	833	1	however	however	ADV
fnp-3806	833	2	,	,	PUNCT
fnp-3806	833	3	spirochetes	spirochete	NOUN
fnp-3806	833	4	,	,	PUNCT
fnp-3806	833	5	including	include	VERB
fnp-3806	833	6	borrelia	borrelia	NOUN
fnp-3806	833	7	and	and	CCONJ
fnp-3806	833	8	treponema	treponema	NOUN
fnp-3806	833	9	,	,	PUNCT
fnp-3806	833	10	were	be	AUX
fnp-3806	833	11	postulated	postulate	VERB
fnp-3806	833	12	as	as	ADP
fnp-3806	833	13	contributing	contribute	VERB
fnp-3806	833	14	factors	factor	NOUN
fnp-3806	833	15	in	in	ADP
fnp-3806	833	16	the	the	DET
fnp-3806	833	17	pathogenesis	pathogenesis	NOUN
fnp-3806	833	18	of	of	ADP
fnp-3806	833	19	the	the	DET
fnp-3806	833	20	disease	disease	NOUN
fnp-3806	833	21	(	(	PUNCT
fnp-3806	833	22	1091	1091	NUM
fnp-3806	833	23	-	-	SYM
fnp-3806	833	24	1094	1094	NUM
fnp-3806	833	25	)	)	PUNCT
fnp-3806	833	26	.	.	PUNCT
fnp-3806	834	1	rrna	rrna	PROPN
fnp-3806	834	2	sequencing	sequencing	NOUN
fnp-3806	834	3	has	have	AUX
fnp-3806	834	4	shown	show	VERB
fnp-3806	834	5	the	the	DET
fnp-3806	834	6	presence	presence	NOUN
fnp-3806	834	7	of	of	ADP
fnp-3806	834	8	bacteria	bacteria	NOUN
fnp-3806	834	9	in	in	ADP
fnp-3806	834	10	alzheimer	alzheimer	PROPN
fnp-3806	834	11	’s	’s	PART
fnp-3806	834	12	post	post	ADJ
fnp-3806	834	13	-	-	ADJ
fnp-3806	834	14	mortem	mortem	ADJ
fnp-3806	834	15	brain	brain	NOUN
fnp-3806	834	16	(	(	PUNCT
fnp-3806	834	17	1095	1095	NUM
fnp-3806	834	18	)	)	PUNCT
fnp-3806	834	19	.	.	PUNCT
fnp-3806	835	1	β	β	X
fnp-3806	835	2	-	-	PUNCT
fnp-3806	835	3	amyloid	amyloid	NOUN
fnp-3806	835	4	exhibits	exhibit	VERB
fnp-3806	835	5	potent	potent	ADJ
fnp-3806	835	6	antimicrobial	antimicrobial	ADJ
fnp-3806	835	7	activity	activity	NOUN
fnp-3806	835	8	against	against	ADP
fnp-3806	835	9	candida	candida	NOUN
fnp-3806	835	10	albicans	albican	NOUN
fnp-3806	835	11	and	and	CCONJ
fnp-3806	835	12	some	some	DET
fnp-3806	835	13	bacteria	bacteria	NOUN
fnp-3806	835	14	,	,	PUNCT
fnp-3806	835	15	pointing	point	VERB
fnp-3806	835	16	to	to	ADP
fnp-3806	835	17	the	the	DET
fnp-3806	835	18	possibility	possibility	NOUN
fnp-3806	835	19	that	that	SCONJ
fnp-3806	835	20	secretion	secretion	NOUN
fnp-3806	835	21	of	of	ADP
fnp-3806	835	22	aβ	aβ	PRON
fnp-3806	835	23	is	be	AUX
fnp-3806	835	24	triggered	trigger	VERB
fnp-3806	835	25	by	by	ADP
fnp-3806	835	26	microbial	microbial	ADJ
fnp-3806	835	27	infection	infection	NOUN
fnp-3806	835	28	(	(	PUNCT
fnp-3806	835	29	1096	1096	NUM
fnp-3806	835	30	)	)	PUNCT
fnp-3806	835	31	.	.	PUNCT
fnp-3806	836	1	numerous	numerous	ADJ
fnp-3806	836	2	periodontal	periodontal	ADJ
fnp-3806	836	3	bacteria	bacteria	NOUN
fnp-3806	836	4	have	have	AUX
fnp-3806	836	5	also	also	ADV
fnp-3806	836	6	been	be	AUX
fnp-3806	836	7	implicated	implicate	VERB
fnp-3806	836	8	in	in	ADP
fnp-3806	836	9	sad	sad	ADJ
fnp-3806	836	10	in	in	ADP
fnp-3806	836	11	the	the	DET
fnp-3806	836	12	context	context	NOUN
fnp-3806	836	13	of	of	ADP
fnp-3806	836	14	chronic	chronic	ADJ
fnp-3806	836	15	periodontitis	periodontitis	NOUN
fnp-3806	836	16	(	(	PUNCT
fnp-3806	836	17	1097	1097	NUM
fnp-3806	836	18	-	-	SYM
fnp-3806	836	19	1099	1099	NUM
fnp-3806	836	20	)	)	PUNCT
fnp-3806	836	21	.	.	PUNCT
fnp-3806	837	1	the	the	DET
fnp-3806	837	2	association	association	NOUN
fnp-3806	837	3	between	between	ADP
fnp-3806	837	4	periodontal	periodontal	ADJ
fnp-3806	837	5	inflammatory	inflammatory	ADJ
fnp-3806	837	6	disease	disease	NOUN
fnp-3806	837	7	and	and	CCONJ
fnp-3806	837	8	sad	sad	ADJ
fnp-3806	837	9	has	have	AUX
fnp-3806	837	10	raised	raise	VERB
fnp-3806	837	11	much	much	ADJ
fnp-3806	837	12	concern	concern	NOUN
fnp-3806	837	13	mainly	mainly	ADV
fnp-3806	837	14	because	because	SCONJ
fnp-3806	837	15	of	of	ADP
fnp-3806	837	16	the	the	DET
fnp-3806	837	17	possibility	possibility	NOUN
fnp-3806	837	18	of	of	ADP
fnp-3806	837	19	rapid	rapid	ADJ
fnp-3806	837	20	therapeutic	therapeutic	ADJ
fnp-3806	837	21	intervention	intervention	NOUN
fnp-3806	837	22	(	(	PUNCT
fnp-3806	837	23	1100	1100	NUM
fnp-3806	837	24	-	-	SYM
fnp-3806	837	25	1102	1102	NUM
fnp-3806	837	26	)	)	PUNCT
fnp-3806	837	27	.	.	PUNCT
fnp-3806	838	1	increased	increase	VERB
fnp-3806	838	2	levels	level	NOUN
fnp-3806	838	3	of	of	ADP
fnp-3806	838	4	anti	anti	ADJ
fnp-3806	838	5	-	-	ADJ
fnp-3806	838	6	helicobacter	helicobacter	ADJ
fnp-3806	838	7	pylori	pylori	NOUN
fnp-3806	838	8	-	-	PUNCT
fnp-3806	838	9	specific	specific	ADJ
fnp-3806	838	10	antibodies	antibody	NOUN
fnp-3806	838	11	were	be	AUX
fnp-3806	838	12	also	also	ADV
fnp-3806	838	13	reported	report	VERB
fnp-3806	838	14	in	in	ADP
fnp-3806	838	15	the	the	DET
fnp-3806	838	16	csf	csf	NOUN
fnp-3806	838	17	and	and	CCONJ
fnp-3806	838	18	serum	serum	NOUN
fnp-3806	838	19	of	of	ADP
fnp-3806	838	20	sad	sad	ADJ
fnp-3806	838	21	patients	patient	NOUN
fnp-3806	838	22	(	(	PUNCT
fnp-3806	838	23	1099	1099	NUM
fnp-3806	838	24	)	)	PUNCT
fnp-3806	838	25	.	.	PUNCT
fnp-3806	839	1	histological	histological	ADJ
fnp-3806	839	2	and	and	CCONJ
fnp-3806	839	3	immunohistochemical	immunohistochemical	ADJ
fnp-3806	839	4	techniques	technique	NOUN
fnp-3806	839	5	have	have	AUX
fnp-3806	839	6	detected	detect	VERB
fnp-3806	839	7	fungi	fungus	NOUN
fnp-3806	839	8	and	and	CCONJ
fnp-3806	839	9	bacteria	bacteria	NOUN
fnp-3806	839	10	in	in	ADP
fnp-3806	839	11	the	the	DET
fnp-3806	839	12	brain	brain	NOUN
fnp-3806	839	13	of	of	ADP
fnp-3806	839	14	sad	sad	ADJ
fnp-3806	839	15	(	(	PUNCT
fnp-3806	839	16	1103	1103	NUM
fnp-3806	839	17	-	-	SYM
fnp-3806	839	18	1105	1105	NUM
fnp-3806	839	19	)	)	PUNCT
fnp-3806	839	20	.	.	PUNCT
fnp-3806	840	1	pcr	pcr	ADJ
fnp-3806	840	2	analysis	analysis	NOUN
fnp-3806	840	3	revealed	reveal	VERB
fnp-3806	840	4	various	various	ADJ
fnp-3806	840	5	fungal	fungal	ADJ
fnp-3806	840	6	species	specie	NOUN
fnp-3806	840	7	in	in	ADP
fnp-3806	840	8	the	the	DET
fnp-3806	840	9	brain	brain	NOUN
fnp-3806	840	10	and	and	CCONJ
fnp-3806	840	11	csf	csf	ADJ
fnp-3806	840	12	in	in	ADP
fnp-3806	840	13	sad	sad	ADJ
fnp-3806	840	14	(	(	PUNCT
fnp-3806	840	15	1106	1106	NUM
fnp-3806	840	16	-	-	SYM
fnp-3806	840	17	1108	1108	NUM
fnp-3806	840	18	)	)	PUNCT
fnp-3806	840	19	.	.	PUNCT
fnp-3806	841	1	a	a	DET
fnp-3806	841	2	combination	combination	NOUN
fnp-3806	841	3	of	of	ADP
fnp-3806	841	4	bacteria	bacteria	NOUN
fnp-3806	841	5	and	and	CCONJ
fnp-3806	841	6	fungi	fungus	NOUN
fnp-3806	841	7	was	be	AUX
fnp-3806	841	8	observed	observe	VERB
fnp-3806	841	9	in	in	ADP
fnp-3806	841	10	several	several	ADJ
fnp-3806	841	11	cases	case	NOUN
fnp-3806	841	12	,	,	PUNCT
fnp-3806	841	13	and	and	CCONJ
fnp-3806	841	14	several	several	ADJ
fnp-3806	841	15	fungi	fungus	NOUN
fnp-3806	841	16	were	be	AUX
fnp-3806	841	17	identified	identify	VERB
fnp-3806	841	18	in	in	ADP
fnp-3806	841	19	different	different	ADJ
fnp-3806	841	20	brain	brain	NOUN
fnp-3806	841	21	regions	region	NOUN
fnp-3806	841	22	in	in	ADP
fnp-3806	841	23	the	the	DET
fnp-3806	841	24	same	same	ADJ
fnp-3806	841	25	individual	individual	NOUN
fnp-3806	841	26	,	,	PUNCT
fnp-3806	841	27	suggesting	suggest	VERB
fnp-3806	841	28	multi	multi	ADJ
fnp-3806	841	29	-	-	ADJ
fnp-3806	841	30	fungal	fungal	ADJ
fnp-3806	841	31	infection	infection	NOUN
fnp-3806	841	32	(	(	PUNCT
fnp-3806	841	33	1107	1107	NUM
fnp-3806	841	34	)	)	PUNCT
fnp-3806	841	35	.	.	PUNCT
fnp-3806	842	1	the	the	DET
fnp-3806	842	2	corpora	corpora	PROPN
fnp-3806	842	3	amylacea	amylacea	PROPN
fnp-3806	842	4	are	be	AUX
fnp-3806	842	5	particularly	particularly	ADV
fnp-3806	842	6	enriched	enrich	VERB
fnp-3806	842	7	in	in	ADP
fnp-3806	842	8	fungal	fungal	ADJ
fnp-3806	842	9	and	and	CCONJ
fnp-3806	842	10	bacterial	bacterial	ADJ
fnp-3806	842	11	peptides	peptide	NOUN
fnp-3806	842	12	,	,	PUNCT
fnp-3806	842	13	acting	act	VERB
fnp-3806	842	14	as	as	ADP
fnp-3806	842	15	scavengers	scavenger	NOUN
fnp-3806	842	16	of	of	ADP
fnp-3806	842	17	microbial	microbial	ADJ
fnp-3806	842	18	debris	debris	NOUN
fnp-3806	842	19	(	(	PUNCT
fnp-3806	842	20	1109	1109	NUM
fnp-3806	842	21	)	)	PUNCT
fnp-3806	842	22	.	.	PUNCT
fnp-3806	843	1	the	the	DET
fnp-3806	843	2	presence	presence	NOUN
fnp-3806	843	3	of	of	ADP
fnp-3806	843	4	fungi	fungi	NOUN
fnp-3806	843	5	is	be	AUX
fnp-3806	843	6	not	not	PART
fnp-3806	843	7	restricted	restrict	VERB
fnp-3806	843	8	to	to	PART
fnp-3806	843	9	sad	sad	ADJ
fnp-3806	843	10	as	as	SCONJ
fnp-3806	843	11	they	they	PRON
fnp-3806	843	12	have	have	AUX
fnp-3806	843	13	also	also	ADV
fnp-3806	843	14	been	be	AUX
fnp-3806	843	15	identified	identify	VERB
fnp-3806	843	16	in	in	ADP
fnp-3806	843	17	the	the	DET
fnp-3806	843	18	cns	cns	NOUN
fnp-3806	843	19	and	and	CCONJ
fnp-3806	843	20	csf	csf	ADJ
fnp-3806	843	21	in	in	ADP
fnp-3806	843	22	amyotrophic	amyotrophic	ADJ
fnp-3806	843	23	lateral	lateral	ADJ
fnp-3806	843	24	sclerosis	sclerosis	NOUN
fnp-3806	843	25	(	(	PUNCT
fnp-3806	843	26	1110	1110	NUM
fnp-3806	843	27	,	,	PUNCT
fnp-3806	843	28	1111	1111	NUM
fnp-3806	843	29	)	)	PUNCT
fnp-3806	843	30	.	.	PUNCT
fnp-3806	844	1	herpes	herpe	NOUN
fnp-3806	844	2	viruses	virus	NOUN
fnp-3806	844	3	were	be	AUX
fnp-3806	844	4	proposed	propose	VERB
fnp-3806	844	5	as	as	ADP
fnp-3806	844	6	participants	participant	NOUN
fnp-3806	844	7	in	in	ADP
fnp-3806	844	8	the	the	DET
fnp-3806	844	9	pathogenesis	pathogenesis	NOUN
fnp-3806	844	10	of	of	ADP
fnp-3806	844	11	sad	sad	ADJ
fnp-3806	844	12	about	about	ADV
fnp-3806	844	13	four	four	NUM
fnp-3806	844	14	decades	decade	NOUN
fnp-3806	844	15	ago	ago	ADV
fnp-3806	844	16	(	(	PUNCT
fnp-3806	844	17	1112	1112	NUM
fnp-3806	844	18	,	,	PUNCT
fnp-3806	844	19	1113	1113	NUM
fnp-3806	844	20	)	)	PUNCT
fnp-3806	844	21	.	.	PUNCT
fnp-3806	845	1	since	since	SCONJ
fnp-3806	845	2	then	then	ADV
fnp-3806	845	3	,	,	PUNCT
fnp-3806	845	4	several	several	ADJ
fnp-3806	845	5	studies	study	NOUN
fnp-3806	845	6	have	have	AUX
fnp-3806	845	7	implicated	implicate	VERB
fnp-3806	845	8	herpes	herpe	NOUN
fnp-3806	845	9	viruses	virus	NOUN
fnp-3806	845	10	in	in	ADP
fnp-3806	845	11	sad	sad	ADJ
fnp-3806	845	12	(	(	PUNCT
fnp-3806	845	13	11141116	11141116	NUM
fnp-3806	845	14	)	)	PUNCT
fnp-3806	845	15	.	.	PUNCT
fnp-3806	846	1	herpes	herpe	NOUN
fnp-3806	846	2	simplex	simplex	NOUN
fnp-3806	846	3	virus	virus	NOUN
fnp-3806	846	4	1	1	NUM
fnp-3806	846	5	(	(	PUNCT
fnp-3806	846	6	hsv-1	hsv-1	X
fnp-3806	846	7	)	)	PUNCT
fnp-3806	846	8	has	have	AUX
fnp-3806	846	9	received	receive	VERB
fnp-3806	846	10	much	much	ADJ
fnp-3806	846	11	attention	attention	NOUN
fnp-3806	846	12	due	due	ADP
fnp-3806	846	13	to	to	ADP
fnp-3806	846	14	the	the	DET
fnp-3806	846	15	presence	presence	NOUN
fnp-3806	846	16	of	of	ADP
fnp-3806	846	17	high	high	ADJ
fnp-3806	846	18	expression	expression	NOUN
fnp-3806	846	19	levels	level	NOUN
fnp-3806	846	20	in	in	ADP
fnp-3806	846	21	the	the	DET
fnp-3806	846	22	brain	brain	NOUN
fnp-3806	846	23	and	and	CCONJ
fnp-3806	846	24	hsv-1	hsv-1	NOUN
fnp-3806	846	25	igg	igg	PROPN
fnp-3806	846	26	antibodies	antibodie	VERB
fnp-3806	846	27	in	in	ADP
fnp-3806	846	28	the	the	DET
fnp-3806	846	29	csf	csf	NOUN
fnp-3806	846	30	(	(	PUNCT
fnp-3806	846	31	1117	1117	NUM
fnp-3806	846	32	-	-	SYM
fnp-3806	846	33	1121	1121	NUM
fnp-3806	846	34	)	)	PUNCT
fnp-3806	846	35	.	.	PUNCT
fnp-3806	847	1	interestingly	interestingly	ADV
fnp-3806	847	2	,	,	PUNCT
fnp-3806	847	3	hsv-1	hsv-1	X
fnp-3806	847	4	dna	dna	PROPN
fnp-3806	847	5	is	be	AUX
fnp-3806	847	6	localized	localize	VERB
fnp-3806	847	7	in	in	ADP
fnp-3806	847	8	senile	senile	ADJ
fnp-3806	847	9	plaques	plaque	NOUN
fnp-3806	847	10	(	(	PUNCT
fnp-3806	847	11	1122	1122	NUM
fnp-3806	847	12	)	)	PUNCT
fnp-3806	847	13	.	.	PUNCT
fnp-3806	848	1	the	the	DET
fnp-3806	848	2	link	link	NOUN
fnp-3806	848	3	between	between	ADP
fnp-3806	848	4	herpes	herpe	NOUN
fnp-3806	848	5	zoster	zoster	NOUN
fnp-3806	848	6	and	and	CCONJ
fnp-3806	848	7	sad	sad	ADJ
fnp-3806	848	8	is	be	AUX
fnp-3806	848	9	still	still	ADV
fnp-3806	848	10	controversial	controversial	ADJ
fnp-3806	848	11	(	(	PUNCT
fnp-3806	848	12	1123	1123	NUM
fnp-3806	848	13	)	)	PUNCT
fnp-3806	848	14	.	.	PUNCT
fnp-3806	849	1	human	human	ADJ
fnp-3806	849	2	cytomegalovirus	cytomegalovirus	NOUN
fnp-3806	849	3	(	(	PUNCT
fnp-3806	849	4	cmv	cmv	NOUN
fnp-3806	849	5	)	)	PUNCT
fnp-3806	849	6	seropositivity	seropositivity	NOUN
fnp-3806	849	7	was	be	AUX
fnp-3806	849	8	associated	associate	VERB
fnp-3806	849	9	with	with	ADP
fnp-3806	849	10	a	a	DET
fnp-3806	849	11	risk	risk	NOUN
fnp-3806	849	12	of	of	ADP
fnp-3806	849	13	sad	sad	ADJ
fnp-3806	849	14	(	(	PUNCT
fnp-3806	849	15	1124	1124	NUM
fnp-3806	849	16	)	)	PUNCT
fnp-3806	849	17	.	.	PUNCT
fnp-3806	850	1	human	human	ADJ
fnp-3806	850	2	herpes	herpe	NOUN
fnp-3806	850	3	virus	virus	NOUN
fnp-3806	850	4	6	6	NUM
fnp-3806	850	5	(	(	PUNCT
fnp-3806	850	6	hhv-6	hhv-6	NOUN
fnp-3806	850	7	)	)	PUNCT
fnp-3806	850	8	has	have	AUX
fnp-3806	850	9	focused	focus	VERB
fnp-3806	850	10	on	on	ADP
fnp-3806	850	11	several	several	ADJ
fnp-3806	850	12	studies	study	NOUN
fnp-3806	850	13	(	(	PUNCT
fnp-3806	850	14	1125	1125	NUM
fnp-3806	850	15	-	-	SYM
fnp-3806	850	16	1128	1128	NUM
fnp-3806	850	17	)	)	PUNCT
fnp-3806	850	18	.	.	PUNCT
fnp-3806	851	1	viral	viral	ADJ
fnp-3806	851	2	associations	association	NOUN
fnp-3806	851	3	have	have	AUX
fnp-3806	851	4	also	also	ADV
fnp-3806	851	5	been	be	AUX
fnp-3806	851	6	reported	report	VERB
fnp-3806	851	7	,	,	PUNCT
fnp-3806	851	8	including	include	VERB
fnp-3806	851	9	hsv-1	hsv-1	X
fnp-3806	851	10	and	and	CCONJ
fnp-3806	851	11	cmv	cmv	NOUN
fnp-3806	851	12	,	,	PUNCT
fnp-3806	851	13	hsv-1	hsv-1	NOUN
fnp-3806	851	14	and	and	CCONJ
fnp-3806	851	15	hhv-6	hhv-6	NOUN
fnp-3806	851	16	,	,	PUNCT
fnp-3806	851	17	hhv-6	hhv-6	NOUN
fnp-3806	851	18	and	and	CCONJ
fnp-3806	851	19	ebv	ebv	PROPN
fnp-3806	851	20	(	(	PUNCT
fnp-3806	851	21	epstein	epstein	PROPN
fnp-3806	851	22	-	-	PUNCT
fnp-3806	851	23	barr	barr	PROPN
fnp-3806	851	24	virus	virus	PROPN
fnp-3806	851	25	)	)	PUNCT
fnp-3806	851	26	,	,	PUNCT
fnp-3806	851	27	and	and	CCONJ
fnp-3806	851	28	hhv-6	hhv-6	NOUN
fnp-3806	851	29	and	and	CCONJ
fnp-3806	851	30	hhv-7	hhv-7	PRON
fnp-3806	851	31	(	(	PUNCT
fnp-3806	851	32	1115	1115	NUM
fnp-3806	851	33	,	,	PUNCT
fnp-3806	851	34	1126	1126	NUM
fnp-3806	851	35	,	,	PUNCT
fnp-3806	851	36	1129	1129	NUM
fnp-3806	851	37	,	,	PUNCT
fnp-3806	851	38	1130	1130	NUM
fnp-3806	851	39	)	)	PUNCT
fnp-3806	851	40	.	.	PUNCT
fnp-3806	852	1	a	a	DET
fnp-3806	852	2	relationship	relationship	NOUN
fnp-3806	852	3	is	be	AUX
fnp-3806	852	4	established	establish	VERB
fnp-3806	852	5	between	between	ADP
fnp-3806	852	6	β	β	NOUN
fnp-3806	852	7	-	-	NOUN
fnp-3806	852	8	amyloid	amyloid	NOUN
fnp-3806	852	9	and	and	CCONJ
fnp-3806	852	10	herpes	herpe	NOUN
fnp-3806	852	11	virus	virus	NOUN
fnp-3806	852	12	,	,	PUNCT
fnp-3806	852	13	suggesting	suggest	VERB
fnp-3806	852	14	a	a	DET
fnp-3806	852	15	mechanism	mechanism	NOUN
fnp-3806	852	16	against	against	ADP
fnp-3806	852	17	brain	brain	NOUN
fnp-3806	852	18	infection	infection	NOUN
fnp-3806	852	19	(	(	PUNCT
fnp-3806	852	20	1131	1131	NUM
fnp-3806	852	21	)	)	PUNCT
fnp-3806	852	22	.	.	PUNCT
fnp-3806	853	1	since	since	SCONJ
fnp-3806	853	2	differences	difference	NOUN
fnp-3806	853	3	in	in	ADP
fnp-3806	853	4	sad	sad	ADJ
fnp-3806	853	5	and	and	CCONJ
fnp-3806	853	6	controls	control	NOUN
fnp-3806	853	7	are	be	AUX
fnp-3806	853	8	not	not	PART
fnp-3806	853	9	always	always	ADV
fnp-3806	853	10	significant	significant	ADJ
fnp-3806	853	11	,	,	PUNCT
fnp-3806	853	12	it	it	PRON
fnp-3806	853	13	is	be	AUX
fnp-3806	853	14	still	still	ADV
fnp-3806	853	15	difficult	difficult	ADJ
fnp-3806	853	16	to	to	PART
fnp-3806	853	17	conclude	conclude	VERB
fnp-3806	853	18	that	that	SCONJ
fnp-3806	853	19	a	a	DET
fnp-3806	853	20	direct	direct	ADJ
fnp-3806	853	21	causal	causal	NOUN
fnp-3806	853	22	relationship	relationship	NOUN
fnp-3806	853	23	exists	exist	VERB
fnp-3806	853	24	between	between	ADP
fnp-3806	853	25	herpes	herpe	NOUN
fnp-3806	853	26	virus	virus	NOUN
fnp-3806	853	27	and	and	CCONJ
fnp-3806	853	28	sad	sad	ADJ
fnp-3806	853	29	.	.	PUNCT
fnp-3806	854	1	the	the	DET
fnp-3806	854	2	hypothesis	hypothesis	NOUN
fnp-3806	854	3	of	of	ADP
fnp-3806	854	4	multi	multi	ADJ
fnp-3806	854	5	-	-	ADJ
fnp-3806	854	6	pathogen	pathogen	NOUN
fnp-3806	854	7	infections	infection	NOUN
fnp-3806	854	8	in	in	ADP
fnp-3806	854	9	the	the	DET
fnp-3806	854	10	pathogenesis	pathogenesis	NOUN
fnp-3806	854	11	of	of	ADP
fnp-3806	854	12	sad	sad	ADJ
fnp-3806	854	13	has	have	AUX
fnp-3806	854	14	recently	recently	ADV
fnp-3806	854	15	been	be	AUX
fnp-3806	854	16	discussed	discuss	VERB
fnp-3806	854	17	(	(	PUNCT
fnp-3806	854	18	1085	1085	NUM
fnp-3806	854	19	)	)	PUNCT
fnp-3806	854	20	.	.	PUNCT
fnp-3806	855	1	moreover	moreover	ADV
fnp-3806	855	2	,	,	PUNCT
fnp-3806	855	3	exposure	exposure	NOUN
fnp-3806	855	4	to	to	ADP
fnp-3806	855	5	systemic	systemic	ADJ
fnp-3806	855	6	infections	infection	NOUN
fnp-3806	855	7	in	in	ADP
fnp-3806	855	8	5xfad	5xfad	NUM
fnp-3806	855	9	transgenic	transgenic	NOUN
fnp-3806	855	10	mice	mouse	NOUN
fnp-3806	855	11	,	,	PUNCT
fnp-3806	855	12	carrying	carry	VERB
fnp-3806	855	13	mutated	mutate	VERB
fnp-3806	855	14	genes	gene	NOUN
fnp-3806	855	15	associated	associate	VERB
fnp-3806	855	16	with	with	ADP
fnp-3806	855	17	fad	fad	NOUN
fnp-3806	855	18	,	,	PUNCT
fnp-3806	855	19	causes	cause	VERB
fnp-3806	855	20	neurodegeneration	neurodegeneration	NOUN
fnp-3806	855	21	in	in	ADP
fnp-3806	855	22	brain	brain	NOUN
fnp-3806	855	23	regions	region	NOUN
fnp-3806	855	24	displaying	display	VERB
fnp-3806	855	25	β	β	NOUN
fnp-3806	855	26	-	-	ADJ
fnp-3806	855	27	amyloid	amyloid	ADJ
fnp-3806	855	28	pathology	pathology	NOUN
fnp-3806	855	29	and	and	CCONJ
fnp-3806	855	30	high	high	ADJ
fnp-3806	855	31	local	local	ADJ
fnp-3806	855	32	microglia	microglia	ADJ
fnp-3806	855	33	density	density	NOUN
fnp-3806	855	34	(	(	PUNCT
fnp-3806	855	35	1132	1132	NUM
fnp-3806	855	36	)	)	PUNCT
fnp-3806	855	37	.	.	PUNCT
fnp-3806	856	1	together	together	ADV
fnp-3806	856	2	,	,	PUNCT
fnp-3806	856	3	the	the	DET
fnp-3806	856	4	available	available	ADJ
fnp-3806	856	5	information	information	NOUN
fnp-3806	856	6	shows	show	VERB
fnp-3806	856	7	that	that	SCONJ
fnp-3806	856	8	the	the	DET
fnp-3806	856	9	human	human	ADJ
fnp-3806	856	10	brain	brain	NOUN
fnp-3806	856	11	,	,	PUNCT
fnp-3806	856	12	particularly	particularly	ADV
fnp-3806	856	13	the	the	DET
fnp-3806	856	14	aged	aged	ADJ
fnp-3806	856	15	brain	brain	NOUN
fnp-3806	856	16	,	,	PUNCT
fnp-3806	856	17	accommodates	accommodate	VERB
fnp-3806	856	18	viruses	virus	NOUN
fnp-3806	856	19	,	,	PUNCT
fnp-3806	856	20	bacteria	bacteria	NOUN
fnp-3806	856	21	,	,	PUNCT
fnp-3806	856	22	and	and	CCONJ
fnp-3806	856	23	fungi	fungus	NOUN
fnp-3806	856	24	,	,	PUNCT
fnp-3806	856	25	together	together	ADV
fnp-3806	856	26	with	with	ADP
fnp-3806	856	27	the	the	DET
fnp-3806	856	28	debris	debris	NOUN
fnp-3806	856	29	of	of	ADP
fnp-3806	856	30	these	these	DET
fnp-3806	856	31	microorganisms	microorganism	NOUN
fnp-3806	856	32	over	over	ADP
fnp-3806	856	33	time	time	NOUN
fnp-3806	856	34	.	.	PUNCT
fnp-3806	857	1	whether	whether	SCONJ
fnp-3806	857	2	brain	brain	NOUN
fnp-3806	857	3	and	and	CCONJ
fnp-3806	857	4	oral	oral	ADJ
fnp-3806	857	5	microorganisms	microorganism	NOUN
fnp-3806	857	6	might	might	AUX
fnp-3806	857	7	contribute	contribute	VERB
fnp-3806	857	8	to	to	ADP
fnp-3806	857	9	“	"	PUNCT
fnp-3806	857	10	neuroinflammation	neuroinflammation	NOUN
fnp-3806	857	11	”	"	PUNCT
fnp-3806	857	12	and	and	CCONJ
fnp-3806	857	13	facilitate	facilitate	VERB
fnp-3806	857	14	the	the	DET
fnp-3806	857	15	course	course	NOUN
fnp-3806	857	16	of	of	ADP
fnp-3806	857	17	sad	sad	ADJ
fnp-3806	857	18	remains	remain	NOUN
fnp-3806	857	19	obscure	obscure	ADJ
fnp-3806	857	20	.	.	PUNCT
fnp-3806	858	1	nonetheless	nonetheless	ADV
fnp-3806	858	2	,	,	PUNCT
fnp-3806	858	3	a	a	DET
fnp-3806	858	4	recent	recent	ADJ
fnp-3806	858	5	review	review	NOUN
fnp-3806	858	6	postulates	postulate	VERB
fnp-3806	858	7	a	a	DET
fnp-3806	858	8	link	link	NOUN
fnp-3806	858	9	between	between	ADP
fnp-3806	858	10	the	the	DET
fnp-3806	858	11	β	β	NOUN
fnp-3806	858	12	-	-	ADJ
fnp-3806	858	13	amyloid	amyloid	ADJ
fnp-3806	858	14	cascade	cascade	NOUN
fnp-3806	858	15	hypothesis	hypothesis	NOUN
fnp-3806	858	16	and	and	CCONJ
fnp-3806	858	17	chronic	chronic	ADJ
fnp-3806	858	18	infection	infection	NOUN
fnp-3806	858	19	in	in	ADP
fnp-3806	858	20	sad	sad	ADJ
fnp-3806	858	21	:	:	PUNCT
fnp-3806	858	22	β	β	X
fnp-3806	858	23	-	-	PUNCT
fnp-3806	858	24	amyloid	amyloid	ADJ
fnp-3806	858	25	deposition	deposition	NOUN
fnp-3806	858	26	is	be	AUX
fnp-3806	858	27	produced	produce	VERB
fnp-3806	858	28	in	in	ADP
fnp-3806	858	29	response	response	NOUN
fnp-3806	858	30	to	to	AUX
fnp-3806	858	31	brain	brain	VERB
fnp-3806	858	32	microbial	microbial	ADJ
fnp-3806	858	33	inflammation	inflammation	NOUN
fnp-3806	858	34	(	(	PUNCT
fnp-3806	858	35	1133	1133	NUM
fnp-3806	858	36	)	)	PUNCT
fnp-3806	858	37	.	.	PUNCT
fnp-3806	859	1	16b	16b	PROPN
fnp-3806	859	2	.	.	PUNCT
fnp-3806	860	1	gut	gut	VERB
fnp-3806	860	2	microbiota	microbiota	NOUN
fnp-3806	860	3	in	in	ADP
fnp-3806	860	4	recent	recent	ADJ
fnp-3806	860	5	years	year	NOUN
fnp-3806	860	6	,	,	PUNCT
fnp-3806	860	7	several	several	ADJ
fnp-3806	860	8	studies	study	NOUN
fnp-3806	860	9	have	have	AUX
fnp-3806	860	10	implicated	implicate	VERB
fnp-3806	860	11	the	the	DET
fnp-3806	860	12	“	"	PUNCT
fnp-3806	860	13	gut	gut	NOUN
fnp-3806	860	14	-	-	PUNCT
fnp-3806	860	15	brain	brain	NOUN
fnp-3806	860	16	-	-	PUNCT
fnp-3806	860	17	microbiota	microbiota	NOUN
fnp-3806	860	18	axis	axis	NOUN
fnp-3806	860	19	”	"	PUNCT
fnp-3806	860	20	in	in	ADP
fnp-3806	860	21	the	the	DET
fnp-3806	860	22	pathogenesis	pathogenesis	NOUN
fnp-3806	860	23	of	of	ADP
fnp-3806	860	24	sad	sad	ADJ
fnp-3806	860	25	;	;	PUNCT
fnp-3806	860	26	altered	alter	VERB
fnp-3806	860	27	gut	gut	NOUN
fnp-3806	860	28	microbiota	microbiota	NOUN
fnp-3806	860	29	may	may	AUX
fnp-3806	860	30	promote	promote	VERB
fnp-3806	860	31	neuroinflammation	neuroinflammation	NOUN
fnp-3806	860	32	,	,	PUNCT
fnp-3806	860	33	aβ	aβ	DET
fnp-3806	860	34	aggregation	aggregation	NOUN
fnp-3806	860	35	,	,	PUNCT
fnp-3806	860	36	and	and	CCONJ
fnp-3806	860	37	oxidative	oxidative	ADJ
fnp-3806	860	38	stress	stress	NOUN
fnp-3806	860	39	(	(	PUNCT
fnp-3806	860	40	1134	1134	NUM
fnp-3806	860	41	-	-	SYM
fnp-3806	860	42	1140	1140	NUM
fnp-3806	860	43	)	)	PUNCT
fnp-3806	860	44	.	.	PUNCT
fnp-3806	861	1	the	the	DET
fnp-3806	861	2	putative	putative	ADJ
fnp-3806	861	3	mechanisms	mechanism	NOUN
fnp-3806	861	4	producing	produce	VERB
fnp-3806	861	5	effects	effect	NOUN
fnp-3806	861	6	include	include	VERB
fnp-3806	861	7	changes	change	NOUN
fnp-3806	861	8	in	in	ADP
fnp-3806	861	9	the	the	DET
fnp-3806	861	10	systemic	systemic	ADJ
fnp-3806	861	11	metabolism	metabolism	NOUN
fnp-3806	861	12	that	that	PRON
fnp-3806	861	13	may	may	AUX
fnp-3806	861	14	influence	influence	VERB
fnp-3806	861	15	brain	brain	NOUN
fnp-3806	861	16	functions	function	NOUN
fnp-3806	861	17	,	,	PUNCT
fnp-3806	861	18	transfer	transfer	NOUN
fnp-3806	861	19	of	of	ADP
fnp-3806	861	20	microbiota	microbiota	NOUN
fnp-3806	861	21	metabolites	metabolite	NOUN
fnp-3806	861	22	to	to	ADP
fnp-3806	861	23	the	the	DET
fnp-3806	861	24	brain	brain	NOUN
fnp-3806	861	25	through	through	ADP
fnp-3806	861	26	the	the	DET
fnp-3806	861	27	bbb	bbb	NOUN
fnp-3806	861	28	,	,	PUNCT
fnp-3806	861	29	and	and	CCONJ
fnp-3806	861	30	direct	direct	ADJ
fnp-3806	861	31	impact	impact	NOUN
fnp-3806	861	32	of	of	ADP
fnp-3806	861	33	microbiota	microbiota	NOUN
fnp-3806	861	34	reaching	reach	VERB
fnp-3806	861	35	the	the	DET
fnp-3806	861	36	brain	brain	NOUN
fnp-3806	861	37	parenchyma	parenchyma	NOUN
fnp-3806	861	38	.	.	PUNCT
fnp-3806	862	1	serotonin	serotonin	NOUN
fnp-3806	862	2	may	may	AUX
fnp-3806	862	3	play	play	VERB
fnp-3806	862	4	a	a	DET
fnp-3806	862	5	role	role	NOUN
fnp-3806	862	6	in	in	ADP
fnp-3806	862	7	the	the	DET
fnp-3806	862	8	gut	gut	NOUN
fnp-3806	862	9	-	-	PUNCT
fnp-3806	862	10	microbiota	microbiota	NOUN
fnp-3806	862	11	axis	axis	NOUN
fnp-3806	862	12	(	(	PUNCT
fnp-3806	862	13	1141	1141	NUM
fnp-3806	862	14	)	)	PUNCT
fnp-3806	862	15	.	.	PUNCT
fnp-3806	863	1	the	the	DET
fnp-3806	863	2	opioid	opioid	ADJ
fnp-3806	863	3	system	system	NOUN
fnp-3806	863	4	has	have	AUX
fnp-3806	863	5	been	be	AUX
fnp-3806	863	6	postulated	postulate	VERB
fnp-3806	863	7	to	to	PART
fnp-3806	863	8	be	be	AUX
fnp-3806	863	9	contributory	contributory	NOUN
fnp-3806	863	10	as	as	ADV
fnp-3806	863	11	well	well	ADV
fnp-3806	863	12	(	(	PUNCT
fnp-3806	863	13	1142	1142	NUM
fnp-3806	863	14	)	)	PUNCT
fnp-3806	863	15	.	.	PUNCT
fnp-3806	864	1	conversely	conversely	ADV
fnp-3806	864	2	,	,	PUNCT
fnp-3806	864	3	the	the	DET
fnp-3806	864	4	infusion	infusion	NOUN
fnp-3806	864	5	of	of	ADP
fnp-3806	864	6	tracers	tracer	NOUN
fnp-3806	864	7	into	into	ADP
fnp-3806	864	8	the	the	DET
fnp-3806	864	9	lateral	lateral	ADJ
fnp-3806	864	10	ventricle	ventricle	NOUN
fnp-3806	864	11	of	of	ADP
fnp-3806	864	12	rats	rat	NOUN
fnp-3806	864	13	has	have	AUX
fnp-3806	864	14	permitted	permit	VERB
fnp-3806	864	15	their	their	PRON
fnp-3806	864	16	visualization	visualization	NOUN
fnp-3806	864	17	in	in	ADP
fnp-3806	864	18	the	the	DET
fnp-3806	864	19	nasal	nasal	ADJ
fnp-3806	864	20	cavity	cavity	NOUN
fnp-3806	864	21	,	,	PUNCT
fnp-3806	864	22	nasal	nasal	PROPN
fnp-3806	864	23	pharynx	pharynx	NOUN
fnp-3806	864	24	,	,	PUNCT
fnp-3806	864	25	soft	soft	ADJ
fnp-3806	864	26	palate	palate	NOUN
fnp-3806	864	27	,	,	PUNCT
fnp-3806	864	28	and	and	CCONJ
fnp-3806	864	29	esophagus	esophagus	NOUN
fnp-3806	864	30	,	,	PUNCT
fnp-3806	864	31	thus	thus	ADV
fnp-3806	864	32	suggesting	suggest	VERB
fnp-3806	864	33	that	that	SCONJ
fnp-3806	864	34	at	at	ADP
fnp-3806	864	35	least	least	ADJ
fnp-3806	864	36	rats	rat	NOUN
fnp-3806	864	37	can	can	AUX
fnp-3806	864	38	swallow	swallow	VERB
fnp-3806	864	39	waste	waste	NOUN
fnp-3806	864	40	from	from	ADP
fnp-3806	864	41	the	the	DET
fnp-3806	864	42	brain	brain	NOUN
fnp-3806	864	43	(	(	PUNCT
fnp-3806	864	44	1143	1143	NUM
fnp-3806	864	45	)	)	PUNCT
fnp-3806	864	46	.	.	PUNCT
fnp-3806	865	1	17	17	NUM
fnp-3806	865	2	.	.	X
fnp-3806	865	3	seeding	seed	VERB
fnp-3806	865	4	and	and	CCONJ
fnp-3806	865	5	spreading	spread	VERB
fnp-3806	865	6	of	of	ADP
fnp-3806	865	7	β	β	NOUN
fnp-3806	865	8	-	-	NOUN
fnp-3806	865	9	amyloid	amyloid	NOUN
fnp-3806	865	10	and	and	CCONJ
fnp-3806	865	11	tau	tau	PROPN
fnp-3806	865	12	17a	17a	PROPN
fnp-3806	865	13	.	.	PUNCT
fnp-3806	866	1	seeding	seed	VERB
fnp-3806	866	2	β	β	NOUN
fnp-3806	866	3	-	-	NOUN
fnp-3806	866	4	amyloid	amyloid	VERB
fnp-3806	866	5	the	the	DET
fnp-3806	866	6	intracerebral	intracerebral	ADJ
fnp-3806	866	7	injection	injection	NOUN
fnp-3806	866	8	of	of	ADP
fnp-3806	866	9	diluted	diluted	ADJ
fnp-3806	866	10	extracts	extract	NOUN
fnp-3806	866	11	from	from	ADP
fnp-3806	866	12	ad	ad	NOUN
fnp-3806	866	13	brains	brain	NOUN
fnp-3806	866	14	or	or	CCONJ
fnp-3806	866	15	from	from	ADP
fnp-3806	866	16	old	old	ADJ
fnp-3806	866	17	ad	ad	NOUN
fnp-3806	866	18	-	-	PUNCT
fnp-3806	866	19	like	like	ADJ
fnp-3806	866	20	transgenic	transgenic	NOUN
fnp-3806	866	21	mice	mouse	NOUN
fnp-3806	866	22	accelerates	accelerate	VERB
fnp-3806	866	23	β	β	NOUN
fnp-3806	866	24	-	-	ADJ
fnp-3806	866	25	amyloid	amyloid	ADJ
fnp-3806	866	26	deposition	deposition	NOUN
fnp-3806	866	27	in	in	ADP
fnp-3806	866	28	transgenic	transgenic	NOUN
fnp-3806	866	29	mice	mouse	NOUN
fnp-3806	866	30	bearing	bear	VERB
fnp-3806	866	31	app	app	NOUN
fnp-3806	866	32	and/or	and/or	CCONJ
fnp-3806	866	33	psen1	psen1	ADJ
fnp-3806	866	34	mutations	mutation	NOUN
fnp-3806	866	35	(	(	PUNCT
fnp-3806	866	36	1144	1144	NUM
fnp-3806	866	37	-	-	SYM
fnp-3806	866	38	1148	1148	NUM
fnp-3806	866	39	)	)	PUNCT
fnp-3806	866	40	.	.	PUNCT
fnp-3806	867	1	soluble	soluble	ADJ
fnp-3806	867	2	forms	form	NOUN
fnp-3806	867	3	of	of	ADP
fnp-3806	867	4	aβ	aβ	NOUN
fnp-3806	867	5	are	be	AUX
fnp-3806	867	6	particularly	particularly	ADV
fnp-3806	867	7	effective	effective	ADJ
fnp-3806	867	8	at	at	ADP
fnp-3806	867	9	inducing	induce	VERB
fnp-3806	867	10	plaque	plaque	ADJ
fnp-3806	867	11	formation	formation	NOUN
fnp-3806	867	12	(	(	PUNCT
fnp-3806	867	13	1149	1149	NUM
fnp-3806	867	14	)	)	PUNCT
fnp-3806	867	15	.	.	PUNCT
fnp-3806	868	1	plaques	plaque	NOUN
fnp-3806	868	2	not	not	PART
fnp-3806	868	3	only	only	ADV
fnp-3806	868	4	develop	develop	VERB
fnp-3806	868	5	locally	locally	ADV
fnp-3806	868	6	but	but	CCONJ
fnp-3806	868	7	extend	extend	VERB
fnp-3806	868	8	as	as	ADV
fnp-3806	868	9	well	well	ADV
fnp-3806	868	10	to	to	ADP
fnp-3806	868	11	the	the	DET
fnp-3806	868	12	cerebral	cerebral	ADJ
fnp-3806	868	13	cortex	cortex	NOUN
fnp-3806	868	14	distant	distant	ADJ
fnp-3806	868	15	from	from	ADP
fnp-3806	868	16	the	the	DET
fnp-3806	868	17	injection	injection	NOUN
fnp-3806	868	18	site	site	NOUN
fnp-3806	868	19	.	.	PUNCT
fnp-3806	869	1	these	these	DET
fnp-3806	869	2	findings	finding	NOUN
fnp-3806	869	3	support	support	VERB
fnp-3806	869	4	the	the	DET
fnp-3806	869	5	possibility	possibility	NOUN
fnp-3806	869	6	that	that	SCONJ
fnp-3806	869	7	once	once	SCONJ
fnp-3806	869	8	the	the	DET
fnp-3806	869	9	first	first	ADJ
fnp-3806	869	10	β	β	NOUN
fnp-3806	869	11	-	-	ADJ
fnp-3806	869	12	amyloid	amyloid	ADJ
fnp-3806	869	13	deposits	deposit	NOUN
fnp-3806	869	14	appear	appear	VERB
fnp-3806	869	15	they	they	PRON
fnp-3806	869	16	may	may	AUX
fnp-3806	869	17	accelerate	accelerate	VERB
fnp-3806	869	18	the	the	DET
fnp-3806	869	19	accumulation	accumulation	NOUN
fnp-3806	869	20	of	of	ADP
fnp-3806	869	21	additional	additional	ADJ
fnp-3806	869	22	seeding	seeding	NOUN
fnp-3806	869	23	in	in	ADP
fnp-3806	869	24	other	other	ADJ
fnp-3806	869	25	parts	part	NOUN
fnp-3806	869	26	of	of	ADP
fnp-3806	869	27	the	the	DET
fnp-3806	869	28	brain	brain	NOUN
fnp-3806	869	29	,	,	PUNCT
fnp-3806	869	30	thereby	thereby	ADV
fnp-3806	869	31	contributing	contribute	VERB
fnp-3806	869	32	to	to	ADP
fnp-3806	869	33	the	the	DET
fnp-3806	869	34	exponential	exponential	ADJ
fnp-3806	869	35	deposition	deposition	NOUN
fnp-3806	869	36	of	of	ADP
fnp-3806	869	37	β	β	NOUN
fnp-3806	869	38	-	-	NOUN
fnp-3806	869	39	amyloid	amyloid	NOUN
fnp-3806	869	40	(	(	PUNCT
fnp-3806	869	41	1150	1150	NUM
fnp-3806	869	42	)	)	PUNCT
fnp-3806	869	43	.	.	PUNCT
fnp-3806	870	1	neuronal	neuronal	ADJ
fnp-3806	870	2	activity	activity	NOUN
fnp-3806	870	3	regulates	regulate	VERB
fnp-3806	870	4	the	the	DET
fnp-3806	870	5	regional	regional	ADJ
fnp-3806	870	6	vulnerability	vulnerability	NOUN
fnp-3806	870	7	to	to	ADP
fnp-3806	870	8	β	β	NOUN
fnp-3806	870	9	-	-	NOUN
fnp-3806	870	10	amyloid	amyloid	ADJ
fnp-3806	870	11	deposition	deposition	NOUN
fnp-3806	870	12	(	(	PUNCT
fnp-3806	870	13	1151	1151	NUM
fnp-3806	870	14	)	)	PUNCT
fnp-3806	870	15	.	.	PUNCT
fnp-3806	871	1	β	β	X
fnp-3806	871	2	-	-	PUNCT
fnp-3806	871	3	amyloid	amyloid	NOUN
fnp-3806	871	4	seeding	seeding	NOUN
fnp-3806	871	5	and	and	CCONJ
fnp-3806	871	6	spreading	spread	VERB
fnp-3806	871	7	may	may	AUX
fnp-3806	871	8	also	also	ADV
fnp-3806	871	9	occur	occur	VERB
fnp-3806	871	10	following	follow	VERB
fnp-3806	871	11	peripheral	peripheral	ADJ
fnp-3806	871	12	inoculation	inoculation	NOUN
fnp-3806	871	13	of	of	ADP
fnp-3806	871	14	β	β	NOUN
fnp-3806	871	15	-	-	ADJ
fnp-3806	871	16	amyloid	amyloid	ADJ
fnp-3806	871	17	seeds	seed	NOUN
fnp-3806	871	18	(	(	PUNCT
fnp-3806	871	19	1152	1152	NUM
fnp-3806	871	20	)	)	PUNCT
fnp-3806	871	21	.	.	PUNCT
fnp-3806	872	1	however	however	ADV
fnp-3806	872	2	,	,	PUNCT
fnp-3806	872	3	the	the	DET
fnp-3806	872	4	intracellular	intracellular	ADJ
fnp-3806	872	5	mechanisms	mechanism	NOUN
fnp-3806	872	6	linked	link	VERB
fnp-3806	872	7	to	to	ADP
fnp-3806	872	8	the	the	DET
fnp-3806	872	9	formation	formation	NOUN
fnp-3806	872	10	and	and	CCONJ
fnp-3806	872	11	fibrillisation	fibrillisation	NOUN
fnp-3806	872	12	of	of	ADP
fnp-3806	872	13	host	host	NOUN
fnp-3806	872	14	β	β	NOUN
fnp-3806	872	15	-	-	NOUN
fnp-3806	872	16	amyloid	amyloid	NOUN
fnp-3806	872	17	and	and	CCONJ
fnp-3806	872	18	recruited	recruit	VERB
fnp-3806	872	19	β	β	NOUN
fnp-3806	872	20	-	-	NOUN
fnp-3806	872	21	amyloid	amyloid	NOUN
fnp-3806	872	22	spreading	spread	VERB
fnp-3806	872	23	need	need	NOUN
fnp-3806	872	24	clarification	clarification	NOUN
fnp-3806	872	25	.	.	PUNCT
fnp-3806	873	1	intraventricular	intraventricular	ADJ
fnp-3806	873	2	injection	injection	NOUN
fnp-3806	873	3	of	of	ADP
fnp-3806	873	4	aβ	aβ	DET
fnp-3806	873	5	oligomers	oligomer	NOUN
fnp-3806	873	6	in	in	ADP
fnp-3806	873	7	cynomolgus	cynomolgus	ADJ
fnp-3806	873	8	macaques	macaque	NOUN
fnp-3806	873	9	leads	lead	VERB
fnp-3806	873	10	to	to	ADP
fnp-3806	873	11	diffusion	diffusion	NOUN
fnp-3806	873	12	into	into	ADP
fnp-3806	873	13	the	the	DET
fnp-3806	873	14	brain	brain	NOUN
fnp-3806	873	15	,	,	PUNCT
fnp-3806	873	16	causing	cause	VERB
fnp-3806	873	17	tau	tau	PROPN
fnp-3806	873	18	hyperphosphorylation	hyperphosphorylation	NOUN
fnp-3806	873	19	,	,	PUNCT
fnp-3806	873	20	nft	nft	PROPN
fnp-3806	873	21	formation	formation	PROPN
fnp-3806	873	22	,	,	PUNCT
fnp-3806	873	23	synaptic	synaptic	ADJ
fnp-3806	873	24	loss	loss	NOUN
fnp-3806	873	25	,	,	PUNCT
fnp-3806	873	26	and	and	CCONJ
fnp-3806	873	27	astrocyte	astrocyte	NOUN
fnp-3806	873	28	and	and	CCONJ
fnp-3806	873	29	microglial	microglial	ADJ
fnp-3806	873	30	activation	activation	NOUN
fnp-3806	873	31	in	in	ADP
fnp-3806	873	32	regions	region	NOUN
fnp-3806	873	33	of	of	ADP
fnp-3806	873	34	the	the	DET
fnp-3806	873	35	macaque	macaque	ADJ
fnp-3806	873	36	brain	brain	NOUN
fnp-3806	873	37	where	where	SCONJ
fnp-3806	873	38	aβ	aβ	PRON
fnp-3806	873	39	oligomers	oligomer	NOUN
fnp-3806	873	40	are	be	AUX
fnp-3806	873	41	abundant	abundant	ADJ
fnp-3806	873	42	(	(	PUNCT
fnp-3806	873	43	1153	1153	NUM
fnp-3806	873	44	)	)	PUNCT
fnp-3806	873	45	.	.	PUNCT
fnp-3806	874	1	β	β	X
fnp-3806	874	2	-	-	PUNCT
fnp-3806	874	3	amyloid	amyloid	ADJ
fnp-3806	874	4	deposits	deposit	NOUN
fnp-3806	874	5	were	be	AUX
fnp-3806	874	6	also	also	ADV
fnp-3806	874	7	observed	observe	VERB
fnp-3806	874	8	in	in	ADP
fnp-3806	874	9	the	the	DET
fnp-3806	874	10	brains	brain	NOUN
fnp-3806	874	11	of	of	ADP
fnp-3806	874	12	patients	patient	NOUN
fnp-3806	874	13	with	with	ADP
fnp-3806	874	14	iatrogenic	iatrogenic	ADJ
fnp-3806	874	15	creutzfeldt	creutzfeldt	ADJ
fnp-3806	874	16	-	-	ADJ
fnp-3806	874	17	jabob	jabob	ADJ
fnp-3806	874	18	disease	disease	NOUN
fnp-3806	874	19	(	(	PUNCT
fnp-3806	874	20	icjd	icjd	NOUN
fnp-3806	874	21	)	)	PUNCT
fnp-3806	874	22	secondary	secondary	ADJ
fnp-3806	874	23	to	to	ADP
fnp-3806	874	24	cadaveric	cadaveric	ADJ
fnp-3806	874	25	dura	dura	NOUN
fnp-3806	874	26	mater	mater	NOUN
fnp-3806	874	27	grafts	graft	NOUN
fnp-3806	874	28	,	,	PUNCT
fnp-3806	874	29	treatment	treatment	NOUN
fnp-3806	874	30	with	with	ADP
fnp-3806	874	31	cadaveric	cadaveric	ADJ
fnp-3806	874	32	human	human	ADJ
fnp-3806	874	33	growth	growth	NOUN
fnp-3806	874	34	hormone	hormone	NOUN
fnp-3806	874	35	obtained	obtain	VERB
fnp-3806	874	36	from	from	ADP
fnp-3806	874	37	hypophysis	hypophysis	NOUN
fnp-3806	874	38	of	of	ADP
fnp-3806	874	39	cjd	cjd	NOUN
fnp-3806	874	40	-	-	PUNCT
fnp-3806	874	41	affected	affect	VERB
fnp-3806	874	42	donors	donor	NOUN
fnp-3806	874	43	,	,	PUNCT
fnp-3806	874	44	or	or	CCONJ
fnp-3806	874	45	contaminated	contaminate	VERB
fnp-3806	874	46	neurosurgery	neurosurgery	NOUN
fnp-3806	874	47	early	early	ADV
fnp-3806	874	48	in	in	ADP
fnp-3806	874	49	life	life	NOUN
fnp-3806	874	50	(	(	PUNCT
fnp-3806	874	51	1154	1154	NUM
fnp-3806	874	52	)	)	PUNCT
fnp-3806	874	53	.	.	PUNCT
fnp-3806	875	1	17b	17b	NUM
fnp-3806	875	2	.	.	PUNCT
fnp-3806	876	1	tau	tau	PROPN
fnp-3806	876	2	seeding	seed	VERB
fnp-3806	876	3	physiological	physiological	ADJ
fnp-3806	876	4	release	release	NOUN
fnp-3806	876	5	of	of	ADP
fnp-3806	876	6	neuronal	neuronal	ADJ
fnp-3806	876	7	tau	tau	PROPN
fnp-3806	876	8	is	be	AUX
fnp-3806	876	9	stimulated	stimulate	VERB
fnp-3806	876	10	by	by	ADP
fnp-3806	876	11	neuronal	neuronal	ADJ
fnp-3806	876	12	activity	activity	NOUN
fnp-3806	876	13	and	and	CCONJ
fnp-3806	876	14	extracellular	extracellular	ADJ
fnp-3806	876	15	tau	tau	PROPN
fnp-3806	876	16	in	in	ADP
fnp-3806	876	17	vivo	vivo	NOUN
fnp-3806	876	18	(	(	PUNCT
fnp-3806	876	19	1155	1155	NUM
fnp-3806	876	20	-	-	SYM
fnp-3806	876	21	1158	1158	NUM
fnp-3806	876	22	)	)	PUNCT
fnp-3806	876	23	.	.	PUNCT
fnp-3806	877	1	intercellular	intercellular	ADJ
fnp-3806	877	2	tau	tau	PROPN
fnp-3806	877	3	transmission	transmission	NOUN
fnp-3806	877	4	may	may	AUX
fnp-3806	877	5	have	have	VERB
fnp-3806	877	6	physiological	physiological	ADJ
fnp-3806	877	7	functions	function	NOUN
fnp-3806	877	8	that	that	PRON
fnp-3806	877	9	permit	permit	VERB
fnp-3806	877	10	the	the	DET
fnp-3806	877	11	transfer	transfer	NOUN
fnp-3806	877	12	of	of	ADP
fnp-3806	877	13	tau	tau	PROPN
fnp-3806	877	14	status	status	NOUN
fnp-3806	877	15	information	information	NOUN
fnp-3806	877	16	from	from	ADP
fnp-3806	877	17	one	one	NUM
fnp-3806	877	18	neuron	neuron	NOUN
fnp-3806	877	19	to	to	ADP
fnp-3806	877	20	another	another	PRON
fnp-3806	877	21	,	,	PUNCT
fnp-3806	877	22	enabling	enable	VERB
fnp-3806	877	23	them	they	PRON
fnp-3806	877	24	to	to	PART
fnp-3806	877	25	modify	modify	VERB
fnp-3806	877	26	the	the	DET
fnp-3806	877	27	status	status	NOUN
fnp-3806	877	28	of	of	ADP
fnp-3806	877	29	the	the	DET
fnp-3806	877	30	host	host	NOUN
fnp-3806	877	31	tau	tau	NOUN
fnp-3806	877	32	according	accord	VERB
fnp-3806	877	33	to	to	ADP
fnp-3806	877	34	this	this	DET
fnp-3806	877	35	information	information	NOUN
fnp-3806	877	36	.	.	PUNCT
fnp-3806	878	1	this	this	DET
fnp-3806	878	2	mechanism	mechanism	NOUN
fnp-3806	878	3	may	may	AUX
fnp-3806	878	4	lie	lie	VERB
fnp-3806	878	5	behind	behind	ADP
fnp-3806	878	6	the	the	DET
fnp-3806	878	7	activation	activation	NOUN
fnp-3806	878	8	of	of	ADP
fnp-3806	878	9	post	post	ADJ
fnp-3806	878	10	-	-	ADJ
fnp-3806	878	11	translational	translational	ADJ
fnp-3806	878	12	modifications	modification	NOUN
fnp-3806	878	13	of	of	ADP
fnp-3806	878	14	tau	tau	PROPN
fnp-3806	878	15	in	in	ADP
fnp-3806	878	16	the	the	DET
fnp-3806	878	17	host	host	NOUN
fnp-3806	878	18	neuron	neuron	NOUN
fnp-3806	878	19	following	follow	VERB
fnp-3806	878	20	the	the	DET
fnp-3806	878	21	transfer	transfer	NOUN
fnp-3806	878	22	of	of	ADP
fnp-3806	878	23	pathological	pathological	ADJ
fnp-3806	878	24	tau	tau	PROPN
fnp-3806	878	25	in	in	ADP
fnp-3806	878	26	models	model	NOUN
fnp-3806	878	27	of	of	ADP
fnp-3806	878	28	tau	tau	PROPN
fnp-3806	878	29	seeding	seed	VERB
fnp-3806	878	30	and	and	CCONJ
fnp-3806	878	31	spreading	spread	VERB
fnp-3806	878	32	.	.	PUNCT
fnp-3806	879	1	tau	tau	PROPN
fnp-3806	879	2	is	be	AUX
fnp-3806	879	3	secreted	secrete	VERB
fnp-3806	879	4	by	by	ADP
fnp-3806	879	5	exosomes	exosome	NOUN
fnp-3806	879	6	,	,	PUNCT
fnp-3806	879	7	and	and	CCONJ
fnp-3806	879	8	the	the	DET
fnp-3806	879	9	extracellular	extracellular	ADJ
fnp-3806	879	10	appearance	appearance	NOUN
fnp-3806	879	11	of	of	ADP
fnp-3806	879	12	tau	tau	PROPN
fnp-3806	879	13	does	do	AUX
fnp-3806	879	14	not	not	PART
fnp-3806	879	15	depend	depend	VERB
fnp-3806	879	16	on	on	ADP
fnp-3806	879	17	neuronal	neuronal	ADJ
fnp-3806	879	18	death	death	NOUN
fnp-3806	879	19	,	,	PUNCT
fnp-3806	879	20	but	but	CCONJ
fnp-3806	879	21	rather	rather	ADV
fnp-3806	879	22	physiological	physiological	ADJ
fnp-3806	879	23	tau	tau	NOUN
fnp-3806	879	24	transfer	transfer	NOUN
fnp-3806	879	25	from	from	ADP
fnp-3806	879	26	one	one	NUM
fnp-3806	879	27	neuron	neuron	NOUN
fnp-3806	879	28	to	to	ADP
fnp-3806	879	29	another	another	PRON
fnp-3806	879	30	(	(	PUNCT
fnp-3806	879	31	1159	1159	NUM
fnp-3806	879	32	)	)	PUNCT
fnp-3806	879	33	.	.	PUNCT
fnp-3806	880	1	tau	tau	PROPN
fnp-3806	880	2	phosphorylation	phosphorylation	NOUN
fnp-3806	880	3	facilitates	facilitate	VERB
fnp-3806	880	4	tau	tau	PROPN
fnp-3806	880	5	transmission	transmission	NOUN
fnp-3806	880	6	and	and	CCONJ
fnp-3806	880	7	propagation	propagation	NOUN
fnp-3806	880	8	(	(	PUNCT
fnp-3806	880	9	1160	1160	NUM
fnp-3806	880	10	)	)	PUNCT
fnp-3806	880	11	.	.	PUNCT
fnp-3806	881	1	several	several	ADJ
fnp-3806	881	2	studies	study	NOUN
fnp-3806	881	3	have	have	AUX
fnp-3806	881	4	suggested	suggest	VERB
fnp-3806	881	5	that	that	SCONJ
fnp-3806	881	6	the	the	DET
fnp-3806	881	7	progression	progression	NOUN
fnp-3806	881	8	of	of	ADP
fnp-3806	881	9	sad	sad	ADJ
fnp-3806	881	10	and	and	CCONJ
fnp-3806	881	11	other	other	ADJ
fnp-3806	881	12	neurodegenerative	neurodegenerative	ADJ
fnp-3806	881	13	diseases	disease	NOUN
fnp-3806	881	14	with	with	ADP
fnp-3806	881	15	abnormal	abnormal	ADJ
fnp-3806	881	16	protein	protein	NOUN
fnp-3806	881	17	aggregates	aggregate	NOUN
fnp-3806	881	18	occurs	occur	VERB
fnp-3806	881	19	in	in	ADP
fnp-3806	881	20	a	a	DET
fnp-3806	881	21	similar	similar	ADJ
fnp-3806	881	22	way	way	NOUN
fnp-3806	881	23	to	to	ADP
fnp-3806	881	24	prions	prion	NOUN
fnp-3806	881	25	in	in	ADP
fnp-3806	881	26	prion	prion	NOUN
fnp-3806	881	27	diseases	disease	NOUN
fnp-3806	881	28	(	(	PUNCT
fnp-3806	881	29	1161	1161	NUM
fnp-3806	881	30	-	-	SYM
fnp-3806	881	31	1164	1164	NUM
fnp-3806	881	32	)	)	PUNCT
fnp-3806	881	33	.	.	PUNCT
fnp-3806	882	1	in	in	ADP
fnp-3806	882	2	favor	favor	NOUN
fnp-3806	882	3	of	of	ADP
fnp-3806	882	4	this	this	DET
fnp-3806	882	5	hypothesis	hypothesis	NOUN
fnp-3806	882	6	,	,	PUNCT
fnp-3806	882	7	many	many	ADJ
fnp-3806	882	8	experimental	experimental	ADJ
fnp-3806	882	9	designs	design	NOUN
fnp-3806	882	10	in	in	ADP
fnp-3806	882	11	mouse	mouse	NOUN
fnp-3806	882	12	and	and	CCONJ
fnp-3806	882	13	rat	rat	NOUN
fnp-3806	882	14	models	model	NOUN
fnp-3806	882	15	have	have	AUX
fnp-3806	882	16	provided	provide	VERB
fnp-3806	882	17	evidence	evidence	NOUN
fnp-3806	882	18	that	that	SCONJ
fnp-3806	882	19	cells	cell	NOUN
fnp-3806	882	20	have	have	AUX
fnp-3806	882	21	the	the	DET
fnp-3806	882	22	capacity	capacity	NOUN
fnp-3806	882	23	to	to	PART
fnp-3806	882	24	transfer	transfer	VERB
fnp-3806	882	25	tau	tau	PROPN
fnp-3806	882	26	from	from	ADP
fnp-3806	882	27	one	one	NUM
fnp-3806	882	28	cell	cell	NOUN
fnp-3806	882	29	to	to	ADP
fnp-3806	882	30	another	another	PRON
fnp-3806	882	31	.	.	PUNCT
fnp-3806	883	1	the	the	DET
fnp-3806	883	2	over	over	ADP
fnp-3806	883	3	-	-	PUNCT
fnp-3806	883	4	expression	expression	NOUN
fnp-3806	883	5	of	of	ADP
fnp-3806	883	6	human	human	PROPN
fnp-3806	883	7	tau	tau	PROPN
fnp-3806	883	8	p301l	p301l	PROPN
fnp-3806	883	9	restricted	restrict	VERB
fnp-3806	883	10	to	to	ADP
fnp-3806	883	11	the	the	DET
fnp-3806	883	12	entorhinal	entorhinal	ADJ
fnp-3806	883	13	cortex	cortex	NOUN
fnp-3806	883	14	shows	show	VERB
fnp-3806	883	15	the	the	DET
fnp-3806	883	16	progression	progression	NOUN
fnp-3806	883	17	of	of	ADP
fnp-3806	883	18	tau	tau	PROPN
fnp-3806	883	19	without	without	ADP
fnp-3806	883	20	detectable	detectable	ADJ
fnp-3806	883	21	transgene	transgene	NOUN
fnp-3806	883	22	expression	expression	NOUN
fnp-3806	883	23	anterogradely	anterogradely	ADV
fnp-3806	883	24	from	from	ADP
fnp-3806	883	25	the	the	DET
fnp-3806	883	26	entorhinal	entorhinal	ADJ
fnp-3806	883	27	cortex	cortex	NOUN
fnp-3806	883	28	to	to	ADP
fnp-3806	883	29	the	the	DET
fnp-3806	883	30	dentate	dentate	ADJ
fnp-3806	883	31	gyrus	gyrus	NOUN
fnp-3806	883	32	and	and	CCONJ
fnp-3806	883	33	ca1	ca1	NOUN
fnp-3806	883	34	region	region	NOUN
fnp-3806	883	35	of	of	ADP
fnp-3806	883	36	the	the	DET
fnp-3806	883	37	hippocampus	hippocampus	NOUN
fnp-3806	883	38	and	and	CCONJ
fnp-3806	883	39	subiculum	subiculum	NOUN
fnp-3806	883	40	,	,	PUNCT
fnp-3806	883	41	and	and	CCONJ
fnp-3806	883	42	retrogradely	retrogradely	ADV
fnp-3806	883	43	to	to	ADP
fnp-3806	883	44	scattered	scatter	VERB
fnp-3806	883	45	neurons	neuron	NOUN
fnp-3806	883	46	in	in	ADP
fnp-3806	883	47	the	the	DET
fnp-3806	883	48	perirhinal	perirhinal	ADJ
fnp-3806	883	49	and	and	CCONJ
fnp-3806	883	50	secondary	secondary	ADJ
fnp-3806	883	51	somatosensory	somatosensory	NOUN
fnp-3806	883	52	cortex	cortex	NOUN
fnp-3806	883	53	(	(	PUNCT
fnp-3806	883	54	1165	1165	NUM
fnp-3806	883	55	,	,	PUNCT
fnp-3806	883	56	1166	1166	NUM
fnp-3806	883	57	)	)	PUNCT
fnp-3806	883	58	.	.	PUNCT
fnp-3806	884	1	using	use	VERB
fnp-3806	884	2	a	a	DET
fnp-3806	884	3	lentiviral	lentiviral	ADJ
fnp-3806	884	4	-	-	PUNCT
fnp-3806	884	5	mediated	mediate	VERB
fnp-3806	884	6	rat	rat	NOUN
fnp-3806	884	7	model	model	NOUN
fnp-3806	884	8	,	,	PUNCT
fnp-3806	884	9	tau	tau	PROPN
fnp-3806	884	10	protein	protein	NOUN
fnp-3806	884	11	is	be	AUX
fnp-3806	884	12	axonally	axonally	ADV
fnp-3806	884	13	transferred	transfer	VERB
fnp-3806	884	14	from	from	ADP
fnp-3806	884	15	hippocampus	hippocampus	NOUN
fnp-3806	884	16	neurons	neuron	NOUN
fnp-3806	884	17	to	to	ADP
fnp-3806	884	18	neurons	neuron	NOUN
fnp-3806	884	19	of	of	ADP
fnp-3806	884	20	distant	distant	ADJ
fnp-3806	884	21	brain	brain	NOUN
fnp-3806	884	22	regions	region	NOUN
fnp-3806	884	23	such	such	ADJ
fnp-3806	884	24	as	as	ADP
fnp-3806	884	25	the	the	DET
fnp-3806	884	26	olfactory	olfactory	NOUN
fnp-3806	884	27	and	and	CCONJ
fnp-3806	884	28	limbic	limbic	ADJ
fnp-3806	884	29	systems	system	NOUN
fnp-3806	884	30	(	(	PUNCT
fnp-3806	884	31	1167	1167	NUM
fnp-3806	884	32	)	)	PUNCT
fnp-3806	884	33	several	several	ADJ
fnp-3806	884	34	mechanisms	mechanism	NOUN
fnp-3806	884	35	of	of	ADP
fnp-3806	884	36	tau	tau	PROPN
fnp-3806	884	37	release	release	NOUN
fnp-3806	884	38	and	and	CCONJ
fnp-3806	884	39	uptake	uptake	ADJ
fnp-3806	884	40	have	have	AUX
fnp-3806	884	41	been	be	AUX
fnp-3806	884	42	proposed	propose	VERB
fnp-3806	884	43	,	,	PUNCT
fnp-3806	884	44	mainly	mainly	ADV
fnp-3806	884	45	in	in	ADP
fnp-3806	884	46	the	the	DET
fnp-3806	884	47	context	context	NOUN
fnp-3806	884	48	of	of	ADP
fnp-3806	884	49	synaptic	synaptic	ADJ
fnp-3806	884	50	transmission	transmission	NOUN
fnp-3806	884	51	.	.	PUNCT
fnp-3806	885	1	however	however	ADV
fnp-3806	885	2	other	other	ADJ
fnp-3806	885	3	processes	process	NOUN
fnp-3806	885	4	may	may	AUX
fnp-3806	885	5	occur	occur	VERB
fnp-3806	885	6	as	as	ADV
fnp-3806	885	7	well	well	ADV
fnp-3806	885	8	.	.	PUNCT
fnp-3806	886	1	tau	tau	PROPN
fnp-3806	886	2	release	release	NOUN
fnp-3806	886	3	may	may	AUX
fnp-3806	886	4	occur	occur	VERB
fnp-3806	886	5	via	via	ADP
fnp-3806	886	6	(	(	PUNCT
fnp-3806	886	7	snap	snap	VERB
fnp-3806	886	8	:	:	PUNCT
fnp-3806	886	9	soluble	soluble	ADJ
fnp-3806	886	10	nsf	nsf	NOUN
fnp-3806	886	11	attachment	attachment	NOUN
fnp-3806	886	12	protein	protein	NOUN
fnp-3806	886	13	receptor	receptor	NOUN
fnp-3806	886	14	)	)	PUNCT
fnp-3806	886	15	snare	snare	NOUN
fnp-3806	886	16	-	-	PUNCT
fnp-3806	886	17	mediated	mediate	VERB
fnp-3806	886	18	exocytosis	exocytosis	NOUN
fnp-3806	886	19	,	,	PUNCT
fnp-3806	886	20	release	release	NOUN
fnp-3806	886	21	by	by	ADP
fnp-3806	886	22	secretory	secretory	ADJ
fnp-3806	886	23	vesicles	vesicle	NOUN
fnp-3806	886	24	from	from	ADP
fnp-3806	886	25	lysosomes	lysosome	NOUN
fnp-3806	886	26	,	,	PUNCT
fnp-3806	886	27	microvesicle	microvesicle	NOUN
fnp-3806	886	28	shedding	shedding	NOUN
fnp-3806	886	29	,	,	PUNCT
fnp-3806	886	30	and	and	CCONJ
fnp-3806	886	31	direct	direct	ADJ
fnp-3806	886	32	plasma	plasma	NOUN
fnp-3806	886	33	membrane	membrane	NOUN
fnp-3806	886	34	crossing	crossing	NOUN
fnp-3806	886	35	.	.	PUNCT
fnp-3806	887	1	tau	tau	PROPN
fnp-3806	887	2	uptake	uptake	ADJ
fnp-3806	887	3	may	may	AUX
fnp-3806	887	4	occur	occur	VERB
fnp-3806	887	5	via	via	ADP
fnp-3806	887	6	endocytosis	endocytosis	NOUN
fnp-3806	887	7	,	,	PUNCT
fnp-3806	887	8	adsorptive	adsorptive	ADJ
fnp-3806	887	9	endocytosis	endocytosis	NOUN
fnp-3806	887	10	,	,	PUNCT
fnp-3806	887	11	macropinocytosis	macropinocytosis	NOUN
fnp-3806	887	12	,	,	PUNCT
fnp-3806	887	13	transmembrane	transmembrane	NOUN
fnp-3806	887	14	diffusion	diffusion	NOUN
fnp-3806	887	15	,	,	PUNCT
fnp-3806	887	16	and	and	CCONJ
fnp-3806	887	17	nanotunneling	nanotunnele	VERB
fnp-3806	887	18	.	.	PUNCT
fnp-3806	888	1	binding	bind	VERB
fnp-3806	888	2	of	of	ADP
fnp-3806	888	3	phosphorylated	phosphorylate	VERB
fnp-3806	888	4	tau	tau	PROPN
fnp-3806	888	5	to	to	PART
fnp-3806	888	6	ampa	ampa	VERB
fnp-3806	888	7	and	and	CCONJ
fnp-3806	888	8	nmda	nmda	ADJ
fnp-3806	888	9	receptors	receptor	NOUN
fnp-3806	888	10	is	be	AUX
fnp-3806	888	11	another	another	DET
fnp-3806	888	12	putative	putative	ADJ
fnp-3806	888	13	mechanism	mechanism	NOUN
fnp-3806	888	14	(	(	PUNCT
fnp-3806	888	15	1168	1168	NUM
fnp-3806	888	16	-	-	SYM
fnp-3806	888	17	1179	1179	NUM
fnp-3806	888	18	)	)	PUNCT
fnp-3806	888	19	.	.	PUNCT
fnp-3806	889	1	tau	tau	PROPN
fnp-3806	889	2	seeding	seed	VERB
fnp-3806	889	3	and	and	CCONJ
fnp-3806	889	4	spreading	spread	VERB
fnp-3806	889	5	is	be	AUX
fnp-3806	889	6	produced	produce	VERB
fnp-3806	889	7	following	follow	VERB
fnp-3806	889	8	the	the	DET
fnp-3806	889	9	intracerebral	intracerebral	ADJ
fnp-3806	889	10	inoculation	inoculation	NOUN
fnp-3806	889	11	of	of	ADP
fnp-3806	889	12	synthetic	synthetic	ADJ
fnp-3806	889	13	tau	tau	PROPN
fnp-3806	889	14	fibrils	fibril	NOUN
fnp-3806	889	15	(	(	PUNCT
fnp-3806	889	16	1180	1180	NUM
fnp-3806	889	17	,	,	PUNCT
fnp-3806	889	18	1181	1181	NUM
fnp-3806	889	19	)	)	PUNCT
fnp-3806	889	20	,	,	PUNCT
fnp-3806	889	21	and	and	CCONJ
fnp-3806	889	22	the	the	DET
fnp-3806	889	23	inoculation	inoculation	NOUN
fnp-3806	889	24	of	of	ADP
fnp-3806	889	25	fibrillar	fibrillar	ADJ
fnp-3806	889	26	-	-	PUNCT
fnp-3806	889	27	enriched	enrich	VERB
fnp-3806	889	28	fractions	fraction	NOUN
fnp-3806	889	29	from	from	ADP
fnp-3806	889	30	human	human	ADJ
fnp-3806	889	31	and	and	CCONJ
fnp-3806	889	32	mouse	mouse	NOUN
fnp-3806	889	33	brain	brain	NOUN
fnp-3806	889	34	homogenates	homogenate	NOUN
fnp-3806	889	35	of	of	ADP
fnp-3806	889	36	tauopathies	tauopathie	NOUN
fnp-3806	889	37	,	,	PUNCT
fnp-3806	889	38	including	include	VERB
fnp-3806	889	39	sad	sad	ADJ
fnp-3806	889	40	,	,	PUNCT
fnp-3806	889	41	containing	contain	VERB
fnp-3806	889	42	hyper	hyper	NOUN
fnp-3806	889	43	-	-	ADJ
fnp-3806	889	44	phosphorylated	phosphorylate	VERB
fnp-3806	889	45	tau	tau	NOUN
fnp-3806	889	46	(	(	PUNCT
fnp-3806	889	47	1182	1182	NUM
fnp-3806	889	48	-	-	SYM
fnp-3806	889	49	1186	1186	NUM
fnp-3806	889	50	)	)	PUNCT
fnp-3806	889	51	.	.	PUNCT
fnp-3806	890	1	tau	tau	PROPN
fnp-3806	890	2	seeding	seed	VERB
fnp-3806	890	3	and	and	CCONJ
fnp-3806	890	4	spreading	spread	VERB
fnp-3806	890	5	in	in	ADP
fnp-3806	890	6	neurons	neuron	NOUN
fnp-3806	890	7	also	also	ADV
fnp-3806	890	8	occur	occur	VERB
fnp-3806	890	9	following	follow	VERB
fnp-3806	890	10	intracerebral	intracerebral	ADJ
fnp-3806	890	11	inoculation	inoculation	NOUN
fnp-3806	890	12	of	of	ADP
fnp-3806	890	13	similar	similar	ADJ
fnp-3806	890	14	tau	tau	PROPN
fnp-3806	890	15	aggregates	aggregate	NOUN
fnp-3806	890	16	in	in	ADP
fnp-3806	890	17	wild	wild	ADJ
fnp-3806	890	18	type	type	NOUN
fnp-3806	890	19	mice	mouse	NOUN
fnp-3806	890	20	(	(	PUNCT
fnp-3806	890	21	wt	wt	NOUN
fnp-3806	890	22	)	)	PUNCT
fnp-3806	890	23	and	and	CCONJ
fnp-3806	890	24	in	in	ADP
fnp-3806	890	25	transgenic	transgenic	NOUN
fnp-3806	890	26	wt	wt	NUM
fnp-3806	890	27	mice	mouse	NOUN
fnp-3806	890	28	(	(	PUNCT
fnp-3806	890	29	1183	1183	NUM
fnp-3806	890	30	,	,	PUNCT
fnp-3806	890	31	1187	1187	NUM
fnp-3806	890	32	-	-	SYM
fnp-3806	890	33	1194	1194	NUM
fnp-3806	890	34	)	)	PUNCT
fnp-3806	890	35	.	.	PUNCT
fnp-3806	891	1	propagation	propagation	NOUN
fnp-3806	891	2	in	in	ADP
fnp-3806	891	3	these	these	DET
fnp-3806	891	4	models	model	NOUN
fnp-3806	891	5	occurs	occur	VERB
fnp-3806	891	6	through	through	ADP
fnp-3806	891	7	connectivity	connectivity	NOUN
fnp-3806	891	8	rather	rather	ADV
fnp-3806	891	9	than	than	ADP
fnp-3806	891	10	proximity	proximity	NOUN
fnp-3806	891	11	(	(	PUNCT
fnp-3806	891	12	1182	1182	NUM
fnp-3806	891	13	)	)	PUNCT
fnp-3806	891	14	.	.	PUNCT
fnp-3806	892	1	in	in	ADP
fnp-3806	892	2	addition	addition	NOUN
fnp-3806	892	3	to	to	ADP
fnp-3806	892	4	neurons	neuron	NOUN
fnp-3806	892	5	,	,	PUNCT
fnp-3806	892	6	deposits	deposit	NOUN
fnp-3806	892	7	may	may	AUX
fnp-3806	892	8	also	also	ADV
fnp-3806	892	9	occur	occur	VERB
fnp-3806	892	10	in	in	ADP
fnp-3806	892	11	astrocytes	astrocyte	NOUN
fnp-3806	892	12	,	,	PUNCT
fnp-3806	892	13	and	and	CCONJ
fnp-3806	892	14	the	the	DET
fnp-3806	892	15	morphology	morphology	NOUN
fnp-3806	892	16	of	of	ADP
fnp-3806	892	17	glial	glial	ADJ
fnp-3806	892	18	inclusions	inclusion	NOUN
fnp-3806	892	19	appears	appear	VERB
fnp-3806	892	20	to	to	PART
fnp-3806	892	21	mimic	mimic	VERB
fnp-3806	892	22	the	the	DET
fnp-3806	892	23	glial	glial	ADJ
fnp-3806	892	24	aggregates	aggregate	NOUN
fnp-3806	892	25	of	of	ADP
fnp-3806	892	26	the	the	DET
fnp-3806	892	27	corresponding	corresponding	ADJ
fnp-3806	892	28	human	human	ADJ
fnp-3806	892	29	tauopathies	tauopathie	NOUN
fnp-3806	892	30	(	(	PUNCT
fnp-3806	892	31	1183	1183	NUM
fnp-3806	892	32	,	,	PUNCT
fnp-3806	892	33	1188	1188	NUM
fnp-3806	892	34	,	,	PUNCT
fnp-3806	892	35	1189	1189	NUM
fnp-3806	892	36	,	,	PUNCT
fnp-3806	892	37	1195	1195	NUM
fnp-3806	892	38	)	)	PUNCT
fnp-3806	892	39	.	.	PUNCT
fnp-3806	893	1	differences	difference	NOUN
fnp-3806	893	2	in	in	ADP
fnp-3806	893	3	the	the	DET
fnp-3806	893	4	type	type	NOUN
fnp-3806	893	5	of	of	ADP
fnp-3806	893	6	inoculum	inoculum	NOUN
fnp-3806	893	7	that	that	PRON
fnp-3806	893	8	produce	produce	VERB
fnp-3806	893	9	different	different	ADJ
fnp-3806	893	10	protein	protein	NOUN
fnp-3806	893	11	aggregate	aggregate	ADJ
fnp-3806	893	12	deposits	deposit	NOUN
fnp-3806	893	13	in	in	ADP
fnp-3806	893	14	the	the	DET
fnp-3806	893	15	host	host	NOUN
fnp-3806	893	16	and	and	CCONJ
fnp-3806	893	17	variable	variable	ADJ
fnp-3806	893	18	involvement	involvement	NOUN
fnp-3806	893	19	of	of	ADP
fnp-3806	893	20	astrocytes	astrocyte	NOUN
fnp-3806	893	21	have	have	AUX
fnp-3806	893	22	led	lead	VERB
fnp-3806	893	23	to	to	ADP
fnp-3806	893	24	the	the	DET
fnp-3806	893	25	proposal	proposal	NOUN
fnp-3806	893	26	that	that	PRON
fnp-3806	893	27	tau	tau	PROPN
fnp-3806	893	28	strains	strain	NOUN
fnp-3806	893	29	are	be	AUX
fnp-3806	893	30	behind	behind	ADP
fnp-3806	893	31	the	the	DET
fnp-3806	893	32	different	different	ADJ
fnp-3806	893	33	phenotypes	phenotype	NOUN
fnp-3806	893	34	and	and	CCONJ
fnp-3806	893	35	progression	progression	NOUN
fnp-3806	893	36	of	of	ADP
fnp-3806	893	37	human	human	ADJ
fnp-3806	893	38	tauopathies	tauopathie	NOUN
fnp-3806	893	39	(	(	PUNCT
fnp-3806	893	40	1161	1161	NUM
fnp-3806	893	41	,	,	PUNCT
fnp-3806	893	42	1196	1196	NUM
fnp-3806	893	43	-	-	SYM
fnp-3806	893	44	1198	1198	NUM
fnp-3806	893	45	)	)	PUNCT
fnp-3806	893	46	.	.	PUNCT
fnp-3806	894	1	more	more	ADJ
fnp-3806	894	2	refined	refined	ADJ
fnp-3806	894	3	situations	situation	NOUN
fnp-3806	894	4	probably	probably	ADV
fnp-3806	894	5	occur	occur	VERB
fnp-3806	894	6	in	in	ADP
fnp-3806	894	7	human	human	ADJ
fnp-3806	894	8	neurodegenerative	neurodegenerative	ADJ
fnp-3806	894	9	diseases	disease	NOUN
fnp-3806	894	10	.	.	PUNCT
fnp-3806	895	1	for	for	ADP
fnp-3806	895	2	example	example	NOUN
fnp-3806	895	3	,	,	PUNCT
fnp-3806	895	4	sad	sad	ADJ
fnp-3806	895	5	brain	brain	NOUN
fnp-3806	895	6	contains	contain	VERB
fnp-3806	895	7	different	different	ADJ
fnp-3806	895	8	tau	tau	PROPN
fnp-3806	895	9	strains	strain	VERB
fnp-3806	895	10	with	with	ADP
fnp-3806	895	11	particular	particular	ADJ
fnp-3806	895	12	properties	property	NOUN
fnp-3806	895	13	(	(	PUNCT
fnp-3806	895	14	1199	1199	NUM
fnp-3806	895	15	)	)	PUNCT
fnp-3806	895	16	;	;	PUNCT
fnp-3806	895	17	different	different	ADJ
fnp-3806	895	18	tau	tau	PROPN
fnp-3806	895	19	strains	strain	NOUN
fnp-3806	895	20	may	may	AUX
fnp-3806	895	21	contribute	contribute	VERB
fnp-3806	895	22	to	to	ADP
fnp-3806	895	23	the	the	DET
fnp-3806	895	24	clinical	clinical	ADJ
fnp-3806	895	25	heterogeneity	heterogeneity	NOUN
fnp-3806	895	26	of	of	ADP
fnp-3806	895	27	ad	ad	NOUN
fnp-3806	895	28	(	(	PUNCT
fnp-3806	895	29	1200	1200	NUM
fnp-3806	895	30	)	)	PUNCT
fnp-3806	895	31	.	.	PUNCT
fnp-3806	896	1	moreover	moreover	ADV
fnp-3806	896	2	,	,	PUNCT
fnp-3806	896	3	tau	tau	NOUN
fnp-3806	896	4	seeding	seed	VERB
fnp-3806	896	5	and	and	CCONJ
fnp-3806	896	6	spreading	spread	VERB
fnp-3806	896	7	also	also	ADV
fnp-3806	896	8	occur	occur	VERB
fnp-3806	896	9	in	in	ADP
fnp-3806	896	10	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	896	11	in	in	ADP
fnp-3806	896	12	wt	wt	ADP
fnp-3806	896	13	mice	mouse	NOUN
fnp-3806	896	14	following	follow	VERB
fnp-3806	896	15	inoculation	inoculation	NOUN
fnp-3806	896	16	of	of	ADP
fnp-3806	896	17	sarkosyl	sarkosyl	NOUN
fnp-3806	896	18	-	-	PUNCT
fnp-3806	896	19	insoluble	insoluble	ADJ
fnp-3806	896	20	fractions	fraction	NOUN
fnp-3806	896	21	in	in	ADP
fnp-3806	896	22	the	the	DET
fnp-3806	896	23	hippocampus	hippocampus	NOUN
fnp-3806	896	24	and	and	CCONJ
fnp-3806	896	25	corpus	corpus	NOUN
fnp-3806	896	26	callosum	callosum	NOUN
fnp-3806	896	27	of	of	ADP
fnp-3806	896	28	human	human	ADJ
fnp-3806	896	29	brain	brain	NOUN
fnp-3806	896	30	homogenates	homogenate	NOUN
fnp-3806	896	31	from	from	ADP
fnp-3806	896	32	sad	sad	ADJ
fnp-3806	896	33	and	and	CCONJ
fnp-3806	896	34	cases	case	NOUN
fnp-3806	896	35	with	with	ADP
fnp-3806	896	36	primary	primary	ADJ
fnp-3806	896	37	age	age	NOUN
fnp-3806	896	38	-	-	PUNCT
fnp-3806	896	39	related	relate	VERB
fnp-3806	896	40	tauopathy	tauopathy	NOUN
fnp-3806	896	41	(	(	PUNCT
fnp-3806	896	42	part	part	NOUN
fnp-3806	896	43	)	)	PUNCT
fnp-3806	896	44	(	(	PUNCT
fnp-3806	896	45	1191	1191	NUM
fnp-3806	896	46	-	-	SYM
fnp-3806	896	47	1193	1193	NUM
fnp-3806	896	48	)	)	PUNCT
fnp-3806	896	49	.	.	PUNCT
fnp-3806	897	1	yet	yet	ADV
fnp-3806	897	2	,	,	PUNCT
fnp-3806	897	3	tau	tau	PROPN
fnp-3806	897	4	deposits	deposit	NOUN
fnp-3806	897	5	in	in	ADP
fnp-3806	897	6	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	897	7	never	never	ADV
fnp-3806	897	8	occur	occur	VERB
fnp-3806	897	9	in	in	ADP
fnp-3806	897	10	humans	human	NOUN
fnp-3806	897	11	affected	affect	VERB
fnp-3806	897	12	by	by	ADP
fnp-3806	897	13	sad	sad	ADJ
fnp-3806	897	14	and	and	CCONJ
fnp-3806	897	15	part	part	NOUN
fnp-3806	897	16	without	without	ADP
fnp-3806	897	17	co	co	NOUN
fnp-3806	897	18	-	-	NOUN
fnp-3806	897	19	morbidities	morbidity	NOUN
fnp-3806	897	20	(	(	PUNCT
fnp-3806	897	21	see	see	VERB
fnp-3806	897	22	section	section	NOUN
fnp-3806	897	23	21	21	NUM
fnp-3806	897	24	for	for	ADP
fnp-3806	897	25	part	part	NOUN
fnp-3806	897	26	details	detail	NOUN
fnp-3806	897	27	)	)	PUNCT
fnp-3806	897	28	.	.	PUNCT
fnp-3806	898	1	these	these	DET
fnp-3806	898	2	discrepancies	discrepancy	NOUN
fnp-3806	898	3	between	between	ADP
fnp-3806	898	4	human	human	ADJ
fnp-3806	898	5	diseases	disease	NOUN
fnp-3806	898	6	and	and	CCONJ
fnp-3806	898	7	mouse	mouse	NOUN
fnp-3806	898	8	models	model	NOUN
fnp-3806	898	9	may	may	AUX
fnp-3806	898	10	be	be	AUX
fnp-3806	898	11	explained	explain	VERB
fnp-3806	898	12	by	by	ADP
fnp-3806	898	13	the	the	DET
fnp-3806	898	14	differences	difference	NOUN
fnp-3806	898	15	between	between	ADP
fnp-3806	898	16	human	human	ADJ
fnp-3806	898	17	and	and	CCONJ
fnp-3806	898	18	murine	murine	ADJ
fnp-3806	898	19	tau	tau	PROPN
fnp-3806	898	20	(	(	PUNCT
fnp-3806	898	21	1201	1201	NUM
fnp-3806	898	22	,	,	PUNCT
fnp-3806	898	23	1202	1202	NUM
fnp-3806	898	24	)	)	PUNCT
fnp-3806	898	25	.	.	PUNCT
fnp-3806	899	1	whether	whether	SCONJ
fnp-3806	899	2	different	different	ADJ
fnp-3806	899	3	types	type	NOUN
fnp-3806	899	4	of	of	ADP
fnp-3806	899	5	tau	tau	PROPN
fnp-3806	899	6	occur	occur	VERB
fnp-3806	899	7	in	in	ADP
fnp-3806	899	8	neurons	neuron	NOUN
fnp-3806	899	9	and	and	CCONJ
fnp-3806	899	10	glial	glial	ADJ
fnp-3806	899	11	cells	cell	NOUN
fnp-3806	899	12	,	,	PUNCT
fnp-3806	899	13	or	or	CCONJ
fnp-3806	899	14	even	even	ADV
fnp-3806	899	15	in	in	ADP
fnp-3806	899	16	different	different	ADJ
fnp-3806	899	17	neuron	neuron	NOUN
fnp-3806	899	18	populations	population	NOUN
fnp-3806	899	19	granting	grant	VERB
fnp-3806	899	20	selective	selective	ADJ
fnp-3806	899	21	vulnerability	vulnerability	NOUN
fnp-3806	899	22	,	,	PUNCT
fnp-3806	899	23	deserves	deserve	VERB
fnp-3806	899	24	further	further	ADJ
fnp-3806	899	25	research	research	NOUN
fnp-3806	899	26	.	.	PUNCT
fnp-3806	900	1	tau	tau	PROPN
fnp-3806	900	2	seeding	seed	VERB
fnp-3806	900	3	and	and	CCONJ
fnp-3806	900	4	spreading	spread	VERB
fnp-3806	900	5	have	have	AUX
fnp-3806	900	6	also	also	ADV
fnp-3806	900	7	been	be	AUX
fnp-3806	900	8	generated	generate	VERB
fnp-3806	900	9	in	in	ADP
fnp-3806	900	10	rhesus	rhesus	NOUN
fnp-3806	900	11	monkeys	monkey	NOUN
fnp-3806	900	12	after	after	ADP
fnp-3806	900	13	the	the	DET
fnp-3806	900	14	inoculation	inoculation	NOUN
fnp-3806	900	15	of	of	ADP
fnp-3806	900	16	adeno	adeno	NOUN
fnp-3806	900	17	-	-	PUNCT
fnp-3806	900	18	associated	associate	VERB
fnp-3806	900	19	virus	virus	NOUN
fnp-3806	900	20	expressing	express	VERB
fnp-3806	900	21	a	a	DET
fnp-3806	900	22	double-4rtau	double-4rtau	PROPN
fnp-3806	900	23	mutation	mutation	NOUN
fnp-3806	900	24	in	in	ADP
fnp-3806	900	25	the	the	DET
fnp-3806	900	26	left	left	NOUN
fnp-3806	900	27	hemisphere	hemisphere	ADV
fnp-3806	900	28	(	(	PUNCT
fnp-3806	900	29	1203	1203	NUM
fnp-3806	900	30	)	)	PUNCT
fnp-3806	900	31	.	.	PUNCT
fnp-3806	901	1	tau	tau	PROPN
fnp-3806	901	2	spreading	spread	VERB
fnp-3806	901	3	was	be	AUX
fnp-3806	901	4	accompanied	accompany	VERB
fnp-3806	901	5	by	by	ADP
fnp-3806	901	6	robust	robust	ADJ
fnp-3806	901	7	trem2	trem2	NOUN
fnp-3806	901	8	+	+	CCONJ
fnp-3806	901	9	microglial	microglial	ADJ
fnp-3806	901	10	proliferation	proliferation	NOUN
fnp-3806	901	11	(	(	PUNCT
fnp-3806	901	12	1203	1203	NUM
fnp-3806	901	13	)	)	PUNCT
fnp-3806	901	14	,	,	PUNCT
fnp-3806	901	15	an	an	DET
fnp-3806	901	16	unexpected	unexpected	ADJ
fnp-3806	901	17	observation	observation	NOUN
fnp-3806	901	18	not	not	PART
fnp-3806	901	19	seen	see	VERB
fnp-3806	901	20	in	in	ADP
fnp-3806	901	21	other	other	ADJ
fnp-3806	901	22	models	model	NOUN
fnp-3806	901	23	.	.	PUNCT
fnp-3806	902	1	another	another	DET
fnp-3806	902	2	curious	curious	ADJ
fnp-3806	902	3	observation	observation	NOUN
fnp-3806	902	4	that	that	PRON
fnp-3806	902	5	deserves	deserve	VERB
fnp-3806	902	6	validation	validation	NOUN
fnp-3806	902	7	is	be	AUX
fnp-3806	902	8	the	the	DET
fnp-3806	902	9	triggering	triggering	NOUN
fnp-3806	902	10	of	of	ADP
fnp-3806	902	11	tau	tau	PROPN
fnp-3806	902	12	deposits	deposit	NOUN
fnp-3806	902	13	in	in	ADP
fnp-3806	902	14	tau	tau	PROPN
fnp-3806	902	15	transgenic	transgenic	NOUN
fnp-3806	902	16	mice	mouse	NOUN
fnp-3806	902	17	following	follow	VERB
fnp-3806	902	18	peripheral	peripheral	ADJ
fnp-3806	902	19	administration	administration	NOUN
fnp-3806	902	20	of	of	ADP
fnp-3806	902	21	tau	tau	PROPN
fnp-3806	902	22	aggregates	aggregate	NOUN
fnp-3806	902	23	(	(	PUNCT
fnp-3806	902	24	1204	1204	NUM
fnp-3806	902	25	)	)	PUNCT
fnp-3806	902	26	.	.	PUNCT
fnp-3806	903	1	neuropathological	neuropathological	ADJ
fnp-3806	903	2	studies	study	NOUN
fnp-3806	903	3	in	in	ADP
fnp-3806	903	4	humans	human	NOUN
fnp-3806	903	5	reveal	reveal	VERB
fnp-3806	903	6	the	the	DET
fnp-3806	903	7	beginning	beginning	NOUN
fnp-3806	903	8	of	of	ADP
fnp-3806	903	9	tau	tau	PROPN
fnp-3806	903	10	seeding	seed	VERB
fnp-3806	903	11	in	in	ADP
fnp-3806	903	12	the	the	DET
fnp-3806	903	13	telencephalon	telencephalon	NOUN
fnp-3806	903	14	in	in	ADP
fnp-3806	903	15	sad	sad	ADJ
fnp-3806	903	16	in	in	ADP
fnp-3806	903	17	the	the	DET
fnp-3806	903	18	transentorhinal	transentorhinal	ADJ
fnp-3806	903	19	and	and	CCONJ
fnp-3806	903	20	entorhinal	entorhinal	ADJ
fnp-3806	903	21	cortex	cortex	NOUN
fnp-3806	903	22	,	,	PUNCT
fnp-3806	903	23	and	and	CCONJ
fnp-3806	903	24	from	from	ADP
fnp-3806	903	25	these	these	DET
fnp-3806	903	26	brain	brain	NOUN
fnp-3806	903	27	regions	region	NOUN
fnp-3806	903	28	tau	tau	PROPN
fnp-3806	903	29	spreads	spread	VERB
fnp-3806	903	30	to	to	ADP
fnp-3806	903	31	others	other	NOUN
fnp-3806	903	32	(	(	PUNCT
fnp-3806	903	33	1205	1205	NUM
fnp-3806	903	34	,	,	PUNCT
fnp-3806	903	35	1206	1206	NUM
fnp-3806	903	36	)	)	PUNCT
fnp-3806	903	37	.	.	PUNCT
fnp-3806	904	1	neuroimaging	neuroimage	VERB
fnp-3806	904	2	analysis	analysis	NOUN
fnp-3806	904	3	further	far	ADV
fnp-3806	904	4	support	support	VERB
fnp-3806	904	5	tau	tau	NOUN
fnp-3806	904	6	spreading	spread	VERB
fnp-3806	904	7	along	along	ADP
fnp-3806	904	8	functional	functional	ADJ
fnp-3806	904	9	connectivity	connectivity	NOUN
fnp-3806	904	10	networks	network	NOUN
fnp-3806	904	11	(	(	PUNCT
fnp-3806	904	12	1207	1207	NUM
fnp-3806	904	13	)	)	PUNCT
fnp-3806	904	14	.	.	PUNCT
fnp-3806	905	1	however	however	ADV
fnp-3806	905	2	,	,	PUNCT
fnp-3806	905	3	combined	combined	ADJ
fnp-3806	905	4	post	post	ADJ
fnp-3806	905	5	-	-	ADJ
fnp-3806	905	6	mortem	mortem	ADJ
fnp-3806	905	7	regional	regional	ADJ
fnp-3806	905	8	seed	seed	NOUN
fnp-3806	905	9	amplification	amplification	NOUN
fnp-3806	905	10	and	and	CCONJ
fnp-3806	905	11	pet	pet	ADJ
fnp-3806	905	12	studies	study	NOUN
fnp-3806	905	13	in	in	ADP
fnp-3806	905	14	living	live	VERB
fnp-3806	905	15	individuals	individual	NOUN
fnp-3806	905	16	suggest	suggest	VERB
fnp-3806	905	17	that	that	SCONJ
fnp-3806	905	18	from	from	ADP
fnp-3806	905	19	nft	nft	PROPN
fnp-3806	905	20	braak	braak	PROPN
fnp-3806	905	21	stage	stage	PROPN
fnp-3806	905	22	iii	iii	PROPN
fnp-3806	905	23	onward	onward	NOUN
fnp-3806	905	24	,	,	PUNCT
fnp-3806	905	25	local	local	ADJ
fnp-3806	905	26	replication	replication	NOUN
fnp-3806	905	27	rather	rather	ADV
fnp-3806	905	28	than	than	ADP
fnp-3806	905	29	spreading	spread	VERB
fnp-3806	905	30	between	between	ADP
fnp-3806	905	31	regions	region	NOUN
fnp-3806	905	32	is	be	AUX
fnp-3806	905	33	the	the	DET
fnp-3806	905	34	main	main	ADJ
fnp-3806	905	35	mechanism	mechanism	NOUN
fnp-3806	905	36	to	to	PART
fnp-3806	905	37	explain	explain	VERB
fnp-3806	905	38	progressive	progressive	ADJ
fnp-3806	905	39	tau	tau	PROPN
fnp-3806	905	40	burden	burden	NOUN
fnp-3806	905	41	in	in	ADP
fnp-3806	905	42	sad	sad	ADJ
fnp-3806	905	43	(	(	PUNCT
fnp-3806	905	44	1208	1208	NUM
fnp-3806	905	45	)	)	PUNCT
fnp-3806	905	46	.	.	PUNCT
fnp-3806	906	1	together	together	ADV
fnp-3806	906	2	,	,	PUNCT
fnp-3806	906	3	tau	tau	NOUN
fnp-3806	906	4	seeding	seed	VERB
fnp-3806	906	5	and	and	CCONJ
fnp-3806	906	6	spreading	spread	VERB
fnp-3806	906	7	differ	differ	NOUN
fnp-3806	906	8	from	from	ADP
fnp-3806	906	9	seeding	seed	VERB
fnp-3806	906	10	and	and	CCONJ
fnp-3806	906	11	spreading	spread	VERB
fnp-3806	906	12	of	of	ADP
fnp-3806	906	13	prions	prion	NOUN
fnp-3806	906	14	.	.	PUNCT
fnp-3806	907	1	grossly	grossly	ADV
fnp-3806	907	2	,	,	PUNCT
fnp-3806	907	3	tau	tau	PROPN
fnp-3806	907	4	seeding	seed	VERB
fnp-3806	907	5	and	and	CCONJ
fnp-3806	907	6	spreading	spread	VERB
fnp-3806	907	7	circumvent	circumvent	NOUN
fnp-3806	907	8	certain	certain	ADJ
fnp-3806	907	9	regions	region	NOUN
fnp-3806	907	10	that	that	PRON
fnp-3806	907	11	should	should	AUX
fnp-3806	907	12	be	be	AUX
fnp-3806	907	13	involved	involve	VERB
fnp-3806	907	14	according	accord	VERB
fnp-3806	907	15	to	to	ADP
fnp-3806	907	16	the	the	DET
fnp-3806	907	17	hypotheses	hypothesis	NOUN
fnp-3806	907	18	of	of	ADP
fnp-3806	907	19	either	either	CCONJ
fnp-3806	907	20	neuronal	neuronal	ADJ
fnp-3806	907	21	connectivity	connectivity	NOUN
fnp-3806	907	22	or	or	CCONJ
fnp-3806	907	23	neuronal	neuronal	ADJ
fnp-3806	907	24	proximity	proximity	NOUN
fnp-3806	907	25	.	.	PUNCT
fnp-3806	908	1	most	most	ADV
fnp-3806	908	2	importantly	importantly	ADV
fnp-3806	908	3	,	,	PUNCT
fnp-3806	908	4	once	once	ADV
fnp-3806	908	5	up	up	ADV
fnp-3806	908	6	-	-	PUNCT
fnp-3806	908	7	taken	take	VERB
fnp-3806	908	8	by	by	ADP
fnp-3806	908	9	the	the	DET
fnp-3806	908	10	receptive	receptive	ADJ
fnp-3806	908	11	neuron	neuron	NOUN
fnp-3806	908	12	,	,	PUNCT
fnp-3806	908	13	abnormal	abnormal	ADJ
fnp-3806	908	14	tau	tau	PROPN
fnp-3806	908	15	triggers	trigger	VERB
fnp-3806	908	16	a	a	DET
fnp-3806	908	17	series	series	NOUN
fnp-3806	908	18	of	of	ADP
fnp-3806	908	19	molecular	molecular	ADJ
fnp-3806	908	20	processes	process	NOUN
fnp-3806	908	21	that	that	PRON
fnp-3806	908	22	include	include	VERB
fnp-3806	908	23	activation	activation	NOUN
fnp-3806	908	24	of	of	ADP
fnp-3806	908	25	several	several	ADJ
fnp-3806	908	26	tau	tau	PROPN
fnp-3806	908	27	kinases	kinase	NOUN
fnp-3806	908	28	,	,	PUNCT
fnp-3806	908	29	post	post	ADJ
fnp-3806	908	30	-	-	ADJ
fnp-3806	908	31	translational	translational	ADJ
fnp-3806	908	32	modifications	modification	NOUN
fnp-3806	908	33	of	of	ADP
fnp-3806	908	34	tau	tau	PROPN
fnp-3806	908	35	—	—	PUNCT
fnp-3806	908	36	for	for	ADP
fnp-3806	908	37	instance	instance	NOUN
fnp-3806	908	38	,	,	PUNCT
fnp-3806	908	39	hyperphosphorylation	hyperphosphorylation	NOUN
fnp-3806	908	40	,	,	PUNCT
fnp-3806	908	41	nitration	nitration	NOUN
fnp-3806	908	42	,	,	PUNCT
fnp-3806	908	43	and	and	CCONJ
fnp-3806	908	44	altered	altered	ADJ
fnp-3806	908	45	conformation	conformation	NOUN
fnp-3806	908	46	;	;	PUNCT
fnp-3806	908	47	recruitment	recruitment	NOUN
fnp-3806	908	48	of	of	ADP
fnp-3806	908	49	additional	additional	ADJ
fnp-3806	908	50	substrates	substrate	NOUN
fnp-3806	908	51	in	in	ADP
fnp-3806	908	52	tau	tau	PROPN
fnp-3806	908	53	deposits	deposit	NOUN
fnp-3806	908	54	;	;	PUNCT
fnp-3806	908	55	and	and	CCONJ
fnp-3806	908	56	modifications	modification	NOUN
fnp-3806	908	57	in	in	ADP
fnp-3806	908	58	the	the	DET
fnp-3806	908	59	ratio	ratio	NOUN
fnp-3806	908	60	of	of	ADP
fnp-3806	908	61	3rtau/4rtau	3rtau/4rtau	NUM
fnp-3806	908	62	in	in	ADP
fnp-3806	908	63	the	the	DET
fnp-3806	908	64	host	host	NOUN
fnp-3806	908	65	neuron	neuron	NOUN
fnp-3806	908	66	(	(	PUNCT
fnp-3806	908	67	1209	1209	NUM
fnp-3806	908	68	)	)	PUNCT
fnp-3806	908	69	,	,	PUNCT
fnp-3806	908	70	which	which	PRON
fnp-3806	908	71	implies	imply	VERB
fnp-3806	908	72	the	the	DET
fnp-3806	908	73	capacity	capacity	NOUN
fnp-3806	908	74	of	of	ADP
fnp-3806	908	75	foreign	foreign	ADJ
fnp-3806	908	76	abnormal	abnormal	ADJ
fnp-3806	908	77	tau	tau	NOUN
fnp-3806	908	78	to	to	PART
fnp-3806	908	79	modulate	modulate	VERB
fnp-3806	908	80	exon	exon	NOUN
fnp-3806	908	81	10	10	NUM
fnp-3806	908	82	splicing	splicing	NOUN
fnp-3806	908	83	in	in	ADP
fnp-3806	908	84	mapt	mapt	NOUN
fnp-3806	908	85	in	in	ADP
fnp-3806	908	86	the	the	DET
fnp-3806	908	87	host	host	NOUN
fnp-3806	908	88	(	(	PUNCT
fnp-3806	908	89	1190	1190	NUM
fnp-3806	908	90	,	,	PUNCT
fnp-3806	908	91	1191	1191	NUM
fnp-3806	908	92	,	,	PUNCT
fnp-3806	908	93	1202	1202	NUM
fnp-3806	908	94	,	,	PUNCT
fnp-3806	908	95	1209	1209	NUM
fnp-3806	908	96	)	)	PUNCT
fnp-3806	908	97	.	.	PUNCT
fnp-3806	909	1	17c	17c	NUM
fnp-3806	909	2	.	.	PUNCT
fnp-3806	909	3	multiple	multiple	ADJ
fnp-3806	909	4	seeding	seed	VERB
fnp-3806	909	5	foci	focus	NOUN
fnp-3806	909	6	of	of	ADP
fnp-3806	909	7	β	β	NOUN
fnp-3806	909	8	-	-	NOUN
fnp-3806	909	9	amyloid	amyloid	NOUN
fnp-3806	909	10	and	and	CCONJ
fnp-3806	909	11	tau	tau	PROPN
fnp-3806	909	12	pathology	pathology	NOUN
fnp-3806	909	13	;	;	PUNCT
fnp-3806	909	14	vulnerable	vulnerable	ADJ
fnp-3806	909	15	and	and	CCONJ
fnp-3806	909	16	resistant	resistant	ADJ
fnp-3806	909	17	populations	population	NOUN
fnp-3806	909	18	to	to	ADP
fnp-3806	909	19	tau	tau	PROPN
fnp-3806	909	20	seeding	seed	VERB
fnp-3806	909	21	in	in	ADP
fnp-3806	909	22	brain	brain	NOUN
fnp-3806	909	23	aging	aging	NOUN
fnp-3806	909	24	and	and	CCONJ
fnp-3806	909	25	sad	sad	ADJ
fnp-3806	909	26	another	another	DET
fnp-3806	909	27	important	important	ADJ
fnp-3806	909	28	point	point	NOUN
fnp-3806	909	29	is	be	AUX
fnp-3806	909	30	the	the	DET
fnp-3806	909	31	characteristics	characteristic	NOUN
fnp-3806	909	32	of	of	ADP
fnp-3806	909	33	tau	tau	PROPN
fnp-3806	909	34	spreading	spread	VERB
fnp-3806	909	35	in	in	ADP
fnp-3806	909	36	the	the	DET
fnp-3806	909	37	human	human	ADJ
fnp-3806	909	38	brain	brain	NOUN
fnp-3806	909	39	that	that	PRON
fnp-3806	909	40	seem	seem	VERB
fnp-3806	909	41	to	to	PART
fnp-3806	909	42	skip	skip	VERB
fnp-3806	909	43	over	over	ADP
fnp-3806	909	44	obligate	obligate	NOUN
fnp-3806	909	45	regions	region	NOUN
fnp-3806	909	46	on	on	ADP
fnp-3806	909	47	the	the	DET
fnp-3806	909	48	basis	basis	NOUN
fnp-3806	909	49	of	of	ADP
fnp-3806	909	50	cell	cell	NOUN
fnp-3806	909	51	connectivity	connectivity	NOUN
fnp-3806	909	52	.	.	PUNCT
fnp-3806	910	1	the	the	DET
fnp-3806	910	2	dentate	dentate	ADJ
fnp-3806	910	3	gyrus	gyrus	NOUN
fnp-3806	910	4	does	do	AUX
fnp-3806	910	5	not	not	PART
fnp-3806	910	6	show	show	VERB
fnp-3806	910	7	tau	tau	PROPN
fnp-3806	910	8	pathology	pathology	NOUN
fnp-3806	910	9	in	in	ADP
fnp-3806	910	10	ad	ad	NOUN
fnp-3806	910	11	and	and	CCONJ
fnp-3806	910	12	other	other	ADJ
fnp-3806	910	13	3r+4r	3r+4r	NUM
fnp-3806	910	14	tauopathies	tauopathie	NOUN
fnp-3806	910	15	without	without	ADP
fnp-3806	910	16	co	co	NOUN
fnp-3806	910	17	-	-	NOUN
fnp-3806	910	18	morbidities	morbidity	NOUN
fnp-3806	910	19	,	,	PUNCT
fnp-3806	910	20	but	but	CCONJ
fnp-3806	910	21	the	the	DET
fnp-3806	910	22	dentate	dentate	ADJ
fnp-3806	910	23	gyrus	gyrus	NOUN
fnp-3806	910	24	is	be	AUX
fnp-3806	910	25	affected	affect	VERB
fnp-3806	910	26	in	in	ADP
fnp-3806	910	27	3r	3r	NUM
fnp-3806	910	28	-	-	PUNCT
fnp-3806	910	29	tauopathies	tauopathie	NOUN
fnp-3806	910	30	and	and	CCONJ
fnp-3806	910	31	4r	4r	NOUN
fnp-3806	910	32	-	-	PUNCT
fnp-3806	910	33	tauopathies	tauopathie	NOUN
fnp-3806	910	34	.	.	PUNCT
fnp-3806	911	1	alternative	alternative	ADJ
fnp-3806	911	2	pathways	pathway	NOUN
fnp-3806	911	3	from	from	ADP
fnp-3806	911	4	the	the	DET
fnp-3806	911	5	entorhinal	entorhinal	ADJ
fnp-3806	911	6	cortex	cortex	NOUN
fnp-3806	911	7	to	to	ADP
fnp-3806	911	8	the	the	DET
fnp-3806	911	9	hippocampus	hippocampus	NOUN
fnp-3806	911	10	proper	proper	ADJ
fnp-3806	911	11	are	be	AUX
fnp-3806	911	12	possible	possible	ADJ
fnp-3806	911	13	but	but	CCONJ
fnp-3806	911	14	there	there	PRON
fnp-3806	911	15	is	be	VERB
fnp-3806	911	16	no	no	DET
fnp-3806	911	17	clear	clear	ADJ
fnp-3806	911	18	explanation	explanation	NOUN
fnp-3806	911	19	for	for	ADP
fnp-3806	911	20	this	this	DET
fnp-3806	911	21	particular	particular	ADJ
fnp-3806	911	22	pattern	pattern	NOUN
fnp-3806	911	23	in	in	ADP
fnp-3806	911	24	ad	ad	NOUN
fnp-3806	911	25	.	.	PUNCT
fnp-3806	912	1	it	it	PRON
fnp-3806	912	2	may	may	AUX
fnp-3806	912	3	be	be	AUX
fnp-3806	912	4	suggested	suggest	VERB
fnp-3806	912	5	that	that	SCONJ
fnp-3806	912	6	certain	certain	ADJ
fnp-3806	912	7	populations	population	NOUN
fnp-3806	912	8	are	be	AUX
fnp-3806	912	9	able	able	ADJ
fnp-3806	912	10	to	to	PART
fnp-3806	912	11	transfer	transfer	VERB
fnp-3806	912	12	abnormal	abnormal	ADJ
fnp-3806	912	13	tau	tau	NOUN
fnp-3806	912	14	from	from	ADP
fnp-3806	912	15	one	one	NUM
fnp-3806	912	16	neuron	neuron	NOUN
fnp-3806	912	17	to	to	ADP
fnp-3806	912	18	the	the	DET
fnp-3806	912	19	next	next	ADJ
fnp-3806	912	20	in	in	ADP
fnp-3806	912	21	the	the	DET
fnp-3806	912	22	connecting	connect	VERB
fnp-3806	912	23	pathway	pathway	NOUN
fnp-3806	912	24	without	without	ADP
fnp-3806	912	25	recruiting	recruit	VERB
fnp-3806	912	26	host	host	NOUN
fnp-3806	912	27	tau	tau	PROPN
fnp-3806	912	28	and	and	CCONJ
fnp-3806	912	29	forming	form	VERB
fnp-3806	912	30	local	local	ADJ
fnp-3806	912	31	aggregates	aggregate	NOUN
fnp-3806	912	32	within	within	ADP
fnp-3806	912	33	themselves	themselves	PRON
fnp-3806	912	34	.	.	PUNCT
fnp-3806	913	1	regional	regional	ADJ
fnp-3806	913	2	vulnerability	vulnerability	NOUN
fnp-3806	913	3	plays	play	VERB
fnp-3806	913	4	a	a	DET
fnp-3806	913	5	cardinal	cardinal	ADJ
fnp-3806	913	6	role	role	NOUN
fnp-3806	913	7	in	in	ADP
fnp-3806	913	8	tau	tau	PROPN
fnp-3806	913	9	spreading	spread	VERB
fnp-3806	913	10	in	in	ADP
fnp-3806	913	11	ad	ad	NOUN
fnp-3806	913	12	-	-	PUNCT
fnp-3806	913	13	related	relate	VERB
fnp-3806	913	14	animal	animal	NOUN
fnp-3806	913	15	models	model	NOUN
fnp-3806	913	16	(	(	PUNCT
fnp-3806	913	17	1210	1210	NUM
fnp-3806	913	18	)	)	PUNCT
fnp-3806	913	19	.	.	PUNCT
fnp-3806	914	1	in	in	ADP
fnp-3806	914	2	summary	summary	NOUN
fnp-3806	914	3	,	,	PUNCT
fnp-3806	914	4	tau	tau	PROPN
fnp-3806	914	5	seeding	seed	VERB
fnp-3806	914	6	and	and	CCONJ
fnp-3806	914	7	spreading	spread	VERB
fnp-3806	914	8	is	be	AUX
fnp-3806	914	9	not	not	PART
fnp-3806	914	10	the	the	DET
fnp-3806	914	11	only	only	ADJ
fnp-3806	914	12	cause	cause	NOUN
fnp-3806	914	13	of	of	ADP
fnp-3806	914	14	tau	tau	PROPN
fnp-3806	914	15	progression	progression	NOUN
fnp-3806	914	16	in	in	ADP
fnp-3806	914	17	sad	sad	ADJ
fnp-3806	914	18	and	and	CCONJ
fnp-3806	914	19	other	other	ADJ
fnp-3806	914	20	tauopathies	tauopathie	NOUN
fnp-3806	914	21	.	.	PUNCT
fnp-3806	915	1	cellular	cellular	ADJ
fnp-3806	915	2	vulnerability	vulnerability	NOUN
fnp-3806	915	3	,	,	PUNCT
fnp-3806	915	4	including	include	VERB
fnp-3806	915	5	neuronal	neuronal	ADJ
fnp-3806	915	6	,	,	PUNCT
fnp-3806	915	7	astroglial	astroglial	ADJ
fnp-3806	915	8	,	,	PUNCT
fnp-3806	915	9	and	and	CCONJ
fnp-3806	915	10	oligodendroglial	oligodendroglial	ADJ
fnp-3806	915	11	,	,	PUNCT
fnp-3806	915	12	together	together	ADV
fnp-3806	915	13	with	with	ADP
fnp-3806	915	14	regional	regional	ADJ
fnp-3806	915	15	vulnerability	vulnerability	NOUN
fnp-3806	915	16	,	,	PUNCT
fnp-3806	915	17	already	already	ADV
fnp-3806	915	18	highlighted	highlight	VERB
fnp-3806	915	19	several	several	ADJ
fnp-3806	915	20	years	year	NOUN
fnp-3806	915	21	ago	ago	ADV
fnp-3806	915	22	,	,	PUNCT
fnp-3806	915	23	are	be	AUX
fnp-3806	915	24	also	also	ADV
fnp-3806	915	25	key	key	ADJ
fnp-3806	915	26	points	point	NOUN
fnp-3806	915	27	to	to	ADP
fnp-3806	915	28	understanding	understand	VERB
fnp-3806	915	29	tau	tau	PROPN
fnp-3806	915	30	progression	progression	NOUN
fnp-3806	915	31	in	in	ADP
fnp-3806	915	32	sad	sad	ADJ
fnp-3806	915	33	and	and	CCONJ
fnp-3806	915	34	other	other	ADJ
fnp-3806	915	35	tauopathies	tauopathie	NOUN
fnp-3806	915	36	.	.	PUNCT
fnp-3806	916	1	finally	finally	ADV
fnp-3806	916	2	,	,	PUNCT
fnp-3806	916	3	several	several	ADJ
fnp-3806	916	4	studies	study	NOUN
fnp-3806	916	5	implicate	implicate	VERB
fnp-3806	916	6	microglia	microglia	NOUN
fnp-3806	916	7	in	in	ADP
fnp-3806	916	8	the	the	DET
fnp-3806	916	9	process	process	NOUN
fnp-3806	916	10	of	of	ADP
fnp-3806	916	11	tau	tau	PROPN
fnp-3806	916	12	seeding	seed	VERB
fnp-3806	916	13	with	with	ADP
fnp-3806	916	14	apparent	apparent	ADJ
fnp-3806	916	15	enhancing	enhancing	NOUN
fnp-3806	916	16	and	and	CCONJ
fnp-3806	916	17	mitigating	mitigate	VERB
fnp-3806	916	18	effects	effect	NOUN
fnp-3806	916	19	(	(	PUNCT
fnp-3806	916	20	868	868	NUM
fnp-3806	916	21	,	,	PUNCT
fnp-3806	916	22	1211	1211	NUM
fnp-3806	916	23	-	-	SYM
fnp-3806	916	24	1216	1216	NUM
fnp-3806	916	25	)	)	PUNCT
fnp-3806	916	26	.	.	PUNCT
fnp-3806	917	1	another	another	DET
fnp-3806	917	2	study	study	NOUN
fnp-3806	917	3	concludes	conclude	VERB
fnp-3806	917	4	that	that	SCONJ
fnp-3806	917	5	microglia	microglia	NOUN
fnp-3806	917	6	have	have	VERB
fnp-3806	917	7	a	a	DET
fnp-3806	917	8	complex	complex	ADJ
fnp-3806	917	9	role	role	NOUN
fnp-3806	917	10	;	;	PUNCT
fnp-3806	917	11	they	they	PRON
fnp-3806	917	12	are	be	AUX
fnp-3806	917	13	capable	capable	ADJ
fnp-3806	917	14	of	of	ADP
fnp-3806	917	15	taking	take	VERB
fnp-3806	917	16	up	up	ADP
fnp-3806	917	17	and	and	CCONJ
fnp-3806	917	18	breaking	break	VERB
fnp-3806	917	19	down	down	ADP
fnp-3806	917	20	seed	seed	NOUN
fnp-3806	917	21	-	-	PUNCT
fnp-3806	917	22	competent	competent	ADJ
fnp-3806	917	23	tau	tau	NOUN
fnp-3806	917	24	,	,	PUNCT
fnp-3806	917	25	but	but	CCONJ
fnp-3806	917	26	do	do	VERB
fnp-3806	917	27	so	so	ADV
fnp-3806	917	28	inefficiently	inefficiently	ADV
fnp-3806	917	29	and	and	CCONJ
fnp-3806	917	30	could	could	AUX
fnp-3806	917	31	hardly	hardly	ADV
fnp-3806	917	32	play	play	VERB
fnp-3806	917	33	a	a	DET
fnp-3806	917	34	role	role	NOUN
fnp-3806	917	35	in	in	ADP
fnp-3806	917	36	the	the	DET
fnp-3806	917	37	spread	spread	NOUN
fnp-3806	917	38	of	of	ADP
fnp-3806	917	39	tau	tau	PROPN
fnp-3806	917	40	pathology	pathology	NOUN
fnp-3806	917	41	(	(	PUNCT
fnp-3806	917	42	1217	1217	NUM
fnp-3806	917	43	)	)	PUNCT
fnp-3806	917	44	.	.	PUNCT
fnp-3806	918	1	the	the	DET
fnp-3806	918	2	capacity	capacity	NOUN
fnp-3806	918	3	for	for	ADP
fnp-3806	918	4	seeding	seeding	NOUN
fnp-3806	918	5	of	of	ADP
fnp-3806	918	6	β	β	NOUN
fnp-3806	918	7	-	-	NOUN
fnp-3806	918	8	amyloid	amyloid	NOUN
fnp-3806	918	9	and	and	CCONJ
fnp-3806	918	10	tau	tau	PROPN
fnp-3806	918	11	does	do	AUX
fnp-3806	918	12	not	not	PART
fnp-3806	918	13	imply	imply	VERB
fnp-3806	918	14	a	a	DET
fnp-3806	918	15	unique	unique	ADJ
fnp-3806	918	16	origin	origin	NOUN
fnp-3806	918	17	of	of	ADP
fnp-3806	918	18	β	β	NOUN
fnp-3806	918	19	-	-	NOUN
fnp-3806	918	20	amyloid	amyloid	NOUN
fnp-3806	918	21	and	and	CCONJ
fnp-3806	918	22	tau	tau	PROPN
fnp-3806	918	23	pathology	pathology	NOUN
fnp-3806	918	24	in	in	ADP
fnp-3806	918	25	sad	sad	ADJ
fnp-3806	918	26	.	.	PUNCT
fnp-3806	919	1	neuropathological	neuropathological	ADJ
fnp-3806	919	2	studies	study	NOUN
fnp-3806	919	3	at	at	ADP
fnp-3806	919	4	early	early	ADJ
fnp-3806	919	5	stages	stage	NOUN
fnp-3806	919	6	of	of	ADP
fnp-3806	919	7	nft	nft	PROPN
fnp-3806	919	8	and	and	CCONJ
fnp-3806	919	9	sp	sp	ADP
fnp-3806	919	10	pathology	pathology	NOUN
fnp-3806	919	11	have	have	AUX
fnp-3806	919	12	shown	show	VERB
fnp-3806	919	13	that	that	SCONJ
fnp-3806	919	14	independent	independent	ADJ
fnp-3806	919	15	tau	tau	PROPN
fnp-3806	919	16	deposits	deposit	NOUN
fnp-3806	919	17	are	be	AUX
fnp-3806	919	18	localized	localize	VERB
fnp-3806	919	19	in	in	ADP
fnp-3806	919	20	separate	separate	ADJ
fnp-3806	919	21	regions	region	NOUN
fnp-3806	919	22	such	such	ADJ
fnp-3806	919	23	as	as	ADP
fnp-3806	919	24	the	the	DET
fnp-3806	919	25	raphe	raphe	NOUN
fnp-3806	919	26	nuclei	nucleus	NOUN
fnp-3806	919	27	and	and	CCONJ
fnp-3806	919	28	locus	locus	NOUN
fnp-3806	919	29	ceruleus	ceruleus	NOUN
fnp-3806	919	30	,	,	PUNCT
fnp-3806	919	31	transentorhinal	transentorhinal	ADJ
fnp-3806	919	32	and	and	CCONJ
fnp-3806	919	33	entorhinal	entorhinal	ADJ
fnp-3806	919	34	cortex	cortex	NOUN
fnp-3806	919	35	,	,	PUNCT
fnp-3806	919	36	and	and	CCONJ
fnp-3806	919	37	olfactory	olfactory	ADJ
fnp-3806	919	38	bulb	bulb	NOUN
fnp-3806	919	39	,	,	PUNCT
fnp-3806	919	40	in	in	ADP
fnp-3806	919	41	addition	addition	NOUN
fnp-3806	919	42	to	to	ADP
fnp-3806	919	43	isolated	isolated	ADJ
fnp-3806	919	44	tau	tau	PROPN
fnp-3806	919	45	-	-	PUNCT
fnp-3806	919	46	positive	positive	ADJ
fnp-3806	919	47	neurons	neuron	NOUN
fnp-3806	919	48	in	in	ADP
fnp-3806	919	49	other	other	ADJ
fnp-3806	919	50	parts	part	NOUN
fnp-3806	919	51	of	of	ADP
fnp-3806	919	52	the	the	DET
fnp-3806	919	53	brain	brain	NOUN
fnp-3806	919	54	.	.	PUNCT
fnp-3806	920	1	similarly	similarly	ADV
fnp-3806	920	2	,	,	PUNCT
fnp-3806	920	3	β	β	X
fnp-3806	920	4	-	-	NOUN
fnp-3806	920	5	amyloid	amyloid	ADJ
fnp-3806	920	6	deposits	deposit	NOUN
fnp-3806	920	7	in	in	ADP
fnp-3806	920	8	the	the	DET
fnp-3806	920	9	brain	brain	NOUN
fnp-3806	920	10	parenchyma	parenchyma	NOUN
fnp-3806	920	11	are	be	AUX
fnp-3806	920	12	not	not	PART
fnp-3806	920	13	connected	connect	VERB
fnp-3806	920	14	;	;	PUNCT
fnp-3806	920	15	likewise	likewise	ADV
fnp-3806	920	16	there	there	PRON
fnp-3806	920	17	is	be	VERB
fnp-3806	920	18	not	not	PART
fnp-3806	920	19	an	an	DET
fnp-3806	920	20	intimate	intimate	ADJ
fnp-3806	920	21	connection	connection	NOUN
fnp-3806	920	22	of	of	ADP
fnp-3806	920	23	blood	blood	NOUN
fnp-3806	920	24	vessels	vessel	NOUN
fnp-3806	920	25	affected	affect	VERB
fnp-3806	920	26	by	by	ADP
fnp-3806	920	27	β	β	NOUN
fnp-3806	920	28	-	-	NOUN
fnp-3806	920	29	amyloid	amyloid	ADJ
fnp-3806	920	30	angiopathy	angiopathy	NOUN
fnp-3806	920	31	.	.	PUNCT
fnp-3806	921	1	aβ	aβ	PRON
fnp-3806	921	2	and	and	CCONJ
fnp-3806	921	3	tau	tau	PROPN
fnp-3806	921	4	pathology	pathology	NOUN
fnp-3806	921	5	,	,	PUNCT
fnp-3806	921	6	like	like	ADP
fnp-3806	921	7	other	other	ADJ
fnp-3806	921	8	molecular	molecular	ADJ
fnp-3806	921	9	alterations	alteration	NOUN
fnp-3806	921	10	in	in	ADP
fnp-3806	921	11	brain	brain	NOUN
fnp-3806	921	12	aging	aging	NOUN
fnp-3806	921	13	and	and	CCONJ
fnp-3806	921	14	sad	sad	ADJ
fnp-3806	921	15	,	,	PUNCT
fnp-3806	921	16	have	have	VERB
fnp-3806	921	17	multiple	multiple	ADJ
fnp-3806	921	18	and	and	CCONJ
fnp-3806	921	19	separate	separate	ADJ
fnp-3806	921	20	foci	focus	NOUN
fnp-3806	921	21	;	;	PUNCT
fnp-3806	921	22	lesions	lesion	NOUN
fnp-3806	921	23	in	in	ADP
fnp-3806	921	24	aging	age	VERB
fnp-3806	921	25	and	and	CCONJ
fnp-3806	921	26	sad	sad	ADJ
fnp-3806	921	27	do	do	AUX
fnp-3806	921	28	not	not	PART
fnp-3806	921	29	start	start	VERB
fnp-3806	921	30	in	in	ADP
fnp-3806	921	31	a	a	DET
fnp-3806	921	32	single	single	ADJ
fnp-3806	921	33	region	region	NOUN
fnp-3806	921	34	only	only	ADV
fnp-3806	921	35	to	to	PART
fnp-3806	921	36	progress	progress	VERB
fnp-3806	921	37	from	from	ADP
fnp-3806	921	38	that	that	DET
fnp-3806	921	39	site	site	NOUN
fnp-3806	921	40	to	to	ADP
fnp-3806	921	41	the	the	DET
fnp-3806	921	42	whole	whole	ADJ
fnp-3806	921	43	brain	brain	NOUN
fnp-3806	921	44	.	.	PUNCT
fnp-3806	922	1	18	18	NUM
fnp-3806	922	2	.	.	PUNCT
fnp-3806	922	3	neuronal	neuronal	ADJ
fnp-3806	922	4	death	death	NOUN
fnp-3806	922	5	neuronal	neuronal	ADJ
fnp-3806	922	6	depletion	depletion	NOUN
fnp-3806	922	7	in	in	ADP
fnp-3806	922	8	ad	ad	NOUN
fnp-3806	922	9	is	be	AUX
fnp-3806	922	10	the	the	DET
fnp-3806	922	11	result	result	NOUN
fnp-3806	922	12	of	of	ADP
fnp-3806	922	13	cell	cell	NOUN
fnp-3806	922	14	death	death	NOUN
fnp-3806	922	15	and	and	CCONJ
fnp-3806	922	16	lack	lack	NOUN
fnp-3806	922	17	of	of	ADP
fnp-3806	922	18	neuronal	neuronal	ADJ
fnp-3806	922	19	renewal	renewal	NOUN
fnp-3806	922	20	.	.	PUNCT
fnp-3806	923	1	apoptosis	apoptosis	NOUN
fnp-3806	923	2	was	be	AUX
fnp-3806	923	3	postulated	postulate	VERB
fnp-3806	923	4	as	as	ADP
fnp-3806	923	5	a	a	DET
fnp-3806	923	6	major	major	ADJ
fnp-3806	923	7	mechanism	mechanism	NOUN
fnp-3806	923	8	of	of	ADP
fnp-3806	923	9	neuronal	neuronal	ADJ
fnp-3806	923	10	death	death	NOUN
fnp-3806	923	11	in	in	ADP
fnp-3806	923	12	ad	ad	NOUN
fnp-3806	923	13	and	and	CCONJ
fnp-3806	923	14	most	most	ADJ
fnp-3806	923	15	neurodegenerative	neurodegenerative	ADJ
fnp-3806	923	16	diseases	disease	NOUN
fnp-3806	923	17	based	base	VERB
fnp-3806	923	18	on	on	ADP
fnp-3806	923	19	the	the	DET
fnp-3806	923	20	positivity	positivity	NOUN
fnp-3806	923	21	of	of	ADP
fnp-3806	923	22	cells	cell	NOUN
fnp-3806	923	23	stained	stain	VERB
fnp-3806	923	24	with	with	ADP
fnp-3806	923	25	the	the	DET
fnp-3806	923	26	method	method	NOUN
fnp-3806	923	27	of	of	ADP
fnp-3806	923	28	in	in	ADP
fnp-3806	923	29	situ	situ	ADJ
fnp-3806	923	30	end	end	NOUN
fnp-3806	923	31	-	-	PUNCT
fnp-3806	923	32	labeling	labeling	NOUN
fnp-3806	923	33	of	of	ADP
fnp-3806	923	34	nuclear	nuclear	ADJ
fnp-3806	923	35	fragmentation	fragmentation	NOUN
fnp-3806	923	36	,	,	PUNCT
fnp-3806	923	37	and	and	CCONJ
fnp-3806	923	38	immunoreactivity	immunoreactivity	NOUN
fnp-3806	923	39	to	to	ADP
fnp-3806	923	40	cleaved	cleaved	ADJ
fnp-3806	923	41	caspase	caspase	NOUN
fnp-3806	923	42	3	3	NUM
fnp-3806	923	43	(	(	PUNCT
fnp-3806	923	44	1218	1218	NUM
fnp-3806	923	45	-	-	SYM
fnp-3806	923	46	1220	1220	NUM
fnp-3806	923	47	)	)	PUNCT
fnp-3806	923	48	.	.	PUNCT
fnp-3806	924	1	caspase	caspase	NOUN
fnp-3806	924	2	3	3	NUM
fnp-3806	924	3	-	-	PUNCT
fnp-3806	924	4	mediated	mediate	VERB
fnp-3806	924	5	and	and	CCONJ
fnp-3806	924	6	caspase	caspase	PROPN
fnp-3806	924	7	3	3	PROPN
fnp-3806	924	8	-	-	PUNCT
fnp-3806	924	9	non	non	ADJ
fnp-3806	924	10	-	-	ADJ
fnp-3806	924	11	mediated	mediate	VERB
fnp-3806	924	12	apoptosis	apoptosis	NOUN
fnp-3806	924	13	is	be	AUX
fnp-3806	924	14	also	also	ADV
fnp-3806	924	15	supported	support	VERB
fnp-3806	924	16	by	by	ADP
fnp-3806	924	17	studies	study	NOUN
fnp-3806	924	18	in	in	ADP
fnp-3806	924	19	cell	cell	NOUN
fnp-3806	924	20	lines	line	NOUN
fnp-3806	924	21	(	(	PUNCT
fnp-3806	924	22	1221	1221	NUM
fnp-3806	924	23	-	-	SYM
fnp-3806	924	24	1224	1224	NUM
fnp-3806	924	25	)	)	PUNCT
fnp-3806	924	26	.	.	PUNCT
fnp-3806	925	1	however	however	ADV
fnp-3806	925	2	,	,	PUNCT
fnp-3806	925	3	dna	dna	PROPN
fnp-3806	925	4	fragmentation	fragmentation	NOUN
fnp-3806	925	5	occurs	occur	VERB
fnp-3806	925	6	during	during	ADP
fnp-3806	925	7	the	the	DET
fnp-3806	925	8	agonic	agonic	ADJ
fnp-3806	925	9	state	state	NOUN
fnp-3806	925	10	and	and	CCONJ
fnp-3806	925	11	post	post	ADJ
fnp-3806	925	12	-	-	ADJ
fnp-3806	925	13	mortem	mortem	ADJ
fnp-3806	925	14	delay	delay	NOUN
fnp-3806	925	15	,	,	PUNCT
fnp-3806	925	16	and	and	CCONJ
fnp-3806	925	17	active	active	ADJ
fnp-3806	925	18	caspase-3	caspase-3	NUM
fnp-3806	925	19	participates	participate	VERB
fnp-3806	925	20	in	in	ADP
fnp-3806	925	21	tau	tau	PROPN
fnp-3806	925	22	truncation	truncation	NOUN
fnp-3806	925	23	during	during	ADP
fnp-3806	925	24	the	the	DET
fnp-3806	925	25	genesis	genesis	NOUN
fnp-3806	925	26	of	of	ADP
fnp-3806	925	27	nfts	nft	NOUN
fnp-3806	925	28	.	.	PUNCT
fnp-3806	926	1	therefore	therefore	ADV
fnp-3806	926	2	,	,	PUNCT
fnp-3806	926	3	the	the	DET
fnp-3806	926	4	weight	weight	NOUN
fnp-3806	926	5	of	of	ADP
fnp-3806	926	6	apoptosis	apoptosis	NOUN
fnp-3806	926	7	as	as	ADP
fnp-3806	926	8	a	a	DET
fnp-3806	926	9	cause	cause	NOUN
fnp-3806	926	10	of	of	ADP
fnp-3806	926	11	neuron	neuron	NOUN
fnp-3806	926	12	demise	demise	NOUN
fnp-3806	926	13	in	in	ADP
fnp-3806	926	14	ad	ad	NOUN
fnp-3806	926	15	is	be	AUX
fnp-3806	926	16	probably	probably	ADV
fnp-3806	926	17	unevenly	unevenly	ADV
fnp-3806	926	18	represented	represent	VERB
fnp-3806	926	19	.	.	PUNCT
fnp-3806	927	1	necroptosis	necroptosis	NOUN
fnp-3806	927	2	is	be	AUX
fnp-3806	927	3	another	another	DET
fnp-3806	927	4	type	type	NOUN
fnp-3806	927	5	of	of	ADP
fnp-3806	927	6	programmed	program	VERB
fnp-3806	927	7	cell	cell	NOUN
fnp-3806	927	8	death	death	NOUN
fnp-3806	927	9	,	,	PUNCT
fnp-3806	927	10	frequently	frequently	ADV
fnp-3806	927	11	linked	link	VERB
fnp-3806	927	12	to	to	ADP
fnp-3806	927	13	inflammation	inflammation	NOUN
fnp-3806	927	14	that	that	PRON
fnp-3806	927	15	depends	depend	VERB
fnp-3806	927	16	on	on	ADP
fnp-3806	927	17	the	the	DET
fnp-3806	927	18	kinase	kinase	NOUN
fnp-3806	927	19	activity	activity	NOUN
fnp-3806	927	20	of	of	ADP
fnp-3806	927	21	receptor	receptor	NOUN
fnp-3806	927	22	interacting	interact	VERB
fnp-3806	927	23	protein	protein	NOUN
fnp-3806	927	24	3	3	NUM
fnp-3806	927	25	(	(	PUNCT
fnp-3806	927	26	rip3	rip3	PROPN
fnp-3806	927	27	)	)	PUNCT
fnp-3806	927	28	and	and	CCONJ
fnp-3806	927	29	rip1	rip1	PROPN
fnp-3806	927	30	,	,	PUNCT
fnp-3806	927	31	and	and	CCONJ
fnp-3806	927	32	the	the	DET
fnp-3806	927	33	subsequent	subsequent	ADJ
fnp-3806	927	34	activation	activation	NOUN
fnp-3806	927	35	of	of	ADP
fnp-3806	927	36	the	the	DET
fnp-3806	927	37	mixed	mixed	ADJ
fnp-3806	927	38	lineage	lineage	NOUN
fnp-3806	927	39	kinase	kinase	NOUN
fnp-3806	927	40	domain	domain	NOUN
fnp-3806	927	41	-	-	PUNCT
fnp-3806	927	42	like	like	ADJ
fnp-3806	927	43	protein	protein	NOUN
fnp-3806	927	44	(	(	PUNCT
fnp-3806	927	45	mlkl	mlkl	PROPN
fnp-3806	927	46	)	)	PUNCT
fnp-3806	927	47	.	.	PUNCT
fnp-3806	928	1	this	this	DET
fnp-3806	928	2	pathway	pathway	NOUN
fnp-3806	928	3	is	be	AUX
fnp-3806	928	4	activated	activate	VERB
fnp-3806	928	5	in	in	ADP
fnp-3806	928	6	ad	ad	NOUN
fnp-3806	928	7	and	and	CCONJ
fnp-3806	928	8	other	other	ADJ
fnp-3806	928	9	neurodegenerative	neurodegenerative	ADJ
fnp-3806	928	10	diseases	disease	NOUN
fnp-3806	928	11	(	(	PUNCT
fnp-3806	928	12	1225	1225	NUM
fnp-3806	928	13	-	-	SYM
fnp-3806	928	14	1227	1227	NUM
fnp-3806	928	15	)	)	PUNCT
fnp-3806	928	16	.	.	PUNCT
fnp-3806	929	1	neuronal	neuronal	ADJ
fnp-3806	929	2	degeneration	degeneration	NOUN
fnp-3806	929	3	and	and	CCONJ
fnp-3806	929	4	demise	demise	NOUN
fnp-3806	929	5	in	in	ADP
fnp-3806	929	6	ad	ad	NOUN
fnp-3806	929	7	is	be	AUX
fnp-3806	929	8	not	not	PART
fnp-3806	929	9	correlated	correlate	VERB
fnp-3806	929	10	with	with	ADP
fnp-3806	929	11	tau	tau	PROPN
fnp-3806	929	12	pathology	pathology	NOUN
fnp-3806	929	13	(	(	PUNCT
fnp-3806	929	14	1228	1228	NUM
fnp-3806	929	15	,	,	PUNCT
fnp-3806	929	16	1229	1229	NUM
fnp-3806	929	17	)	)	PUNCT
fnp-3806	929	18	,	,	PUNCT
fnp-3806	929	19	although	although	SCONJ
fnp-3806	929	20	ghost	ghost	NOUN
fnp-3806	929	21	tangles	tangle	NOUN
fnp-3806	929	22	are	be	AUX
fnp-3806	929	23	not	not	PART
fnp-3806	929	24	rare	rare	ADJ
fnp-3806	929	25	in	in	ADP
fnp-3806	929	26	advanced	advanced	ADJ
fnp-3806	929	27	stages	stage	NOUN
fnp-3806	929	28	of	of	ADP
fnp-3806	929	29	ad	ad	NOUN
fnp-3806	929	30	.	.	PUNCT
fnp-3806	930	1	intraneuronal	intraneuronal	ADJ
fnp-3806	930	2	accumulation	accumulation	NOUN
fnp-3806	930	3	of	of	ADP
fnp-3806	930	4	β	β	NOUN
fnp-3806	930	5	-	-	NOUN
fnp-3806	930	6	amyloid	amyloid	NOUN
fnp-3806	930	7	is	be	AUX
fnp-3806	930	8	involved	involve	VERB
fnp-3806	930	9	in	in	ADP
fnp-3806	930	10	synaptic	synaptic	ADJ
fnp-3806	930	11	dysfunction	dysfunction	NOUN
fnp-3806	930	12	,	,	PUNCT
fnp-3806	930	13	cognitive	cognitive	ADJ
fnp-3806	930	14	impairment	impairment	NOUN
fnp-3806	930	15	,	,	PUNCT
fnp-3806	930	16	and	and	CCONJ
fnp-3806	930	17	the	the	DET
fnp-3806	930	18	formation	formation	NOUN
fnp-3806	930	19	of	of	ADP
fnp-3806	930	20	amyloid	amyloid	NOUN
fnp-3806	930	21	plaques	plaque	NOUN
fnp-3806	930	22	in	in	ADP
fnp-3806	930	23	ad	ad	NOUN
fnp-3806	930	24	(	(	PUNCT
fnp-3806	930	25	416	416	NUM
fnp-3806	930	26	,	,	PUNCT
fnp-3806	930	27	1230	1230	NUM
fnp-3806	930	28	,	,	PUNCT
fnp-3806	930	29	1231	1231	NUM
fnp-3806	930	30	)	)	PUNCT
fnp-3806	930	31	.	.	PUNCT
fnp-3806	931	1	in	in	ADP
fnp-3806	931	2	addition	addition	NOUN
fnp-3806	931	3	,	,	PUNCT
fnp-3806	931	4	excessive	excessive	ADJ
fnp-3806	931	5	production	production	NOUN
fnp-3806	931	6	of	of	ADP
fnp-3806	931	7	aβ	aβ	NOUN
fnp-3806	931	8	peptides	peptide	NOUN
fnp-3806	931	9	and	and	CCONJ
fnp-3806	931	10	app	app	NOUN
fnp-3806	931	11	activates	activate	VERB
fnp-3806	931	12	death	death	NOUN
fnp-3806	931	13	signaling	signal	VERB
fnp-3806	931	14	pathways	pathway	NOUN
fnp-3806	931	15	including	include	VERB
fnp-3806	931	16	apoptosis	apoptosis	NOUN
fnp-3806	931	17	,	,	PUNCT
fnp-3806	931	18	necrosis	necrosis	NOUN
fnp-3806	931	19	,	,	PUNCT
fnp-3806	931	20	necroptosis	necroptosis	NOUN
fnp-3806	931	21	,	,	PUNCT
fnp-3806	931	22	oxytosis	oxytosis	NOUN
fnp-3806	931	23	(	(	PUNCT
fnp-3806	931	24	gsh	gsh	NOUN
fnp-3806	931	25	-	-	PUNCT
fnp-3806	931	26	mediated	mediate	VERB
fnp-3806	931	27	oxidative	oxidative	ADJ
fnp-3806	931	28	cell	cell	NOUN
fnp-3806	931	29	death	death	NOUN
fnp-3806	931	30	)	)	PUNCT
fnp-3806	931	31	,	,	PUNCT
fnp-3806	931	32	pyroptosis	pyroptosis	NOUN
fnp-3806	931	33	(	(	PUNCT
fnp-3806	931	34	inflammasome	inflammasome	NOUN
fnp-3806	931	35	-	-	PUNCT
fnp-3806	931	36	mediated	mediate	VERB
fnp-3806	931	37	cell	cell	NOUN
fnp-3806	931	38	death	death	NOUN
fnp-3806	931	39	)	)	PUNCT
fnp-3806	931	40	,	,	PUNCT
fnp-3806	931	41	and	and	CCONJ
fnp-3806	931	42	autophagy	autophagy	VERB
fnp-3806	931	43	in	in	ADP
fnp-3806	931	44	vitro	vitro	X
fnp-3806	931	45	(	(	PUNCT
fnp-3806	931	46	1232	1232	NUM
fnp-3806	931	47	)	)	PUNCT
fnp-3806	931	48	.	.	PUNCT
fnp-3806	932	1	in	in	ADP
fnp-3806	932	2	summary	summary	NOUN
fnp-3806	932	3	,	,	PUNCT
fnp-3806	932	4	although	although	SCONJ
fnp-3806	932	5	β	β	NOUN
fnp-3806	932	6	-	-	NOUN
fnp-3806	932	7	amyloid	amyloid	NOUN
fnp-3806	932	8	and	and	CCONJ
fnp-3806	932	9	tau	tau	PROPN
fnp-3806	932	10	pathology	pathology	NOUN
fnp-3806	932	11	may	may	AUX
fnp-3806	932	12	induce	induce	VERB
fnp-3806	932	13	cell	cell	NOUN
fnp-3806	932	14	death	death	NOUN
fnp-3806	932	15	in	in	ADP
fnp-3806	932	16	sad	sad	ADJ
fnp-3806	932	17	,	,	PUNCT
fnp-3806	932	18	they	they	PRON
fnp-3806	932	19	are	be	AUX
fnp-3806	932	20	not	not	PART
fnp-3806	932	21	the	the	DET
fnp-3806	932	22	only	only	ADJ
fnp-3806	932	23	factors	factor	NOUN
fnp-3806	932	24	triggering	trigger	VERB
fnp-3806	932	25	active	active	ADJ
fnp-3806	932	26	cell	cell	NOUN
fnp-3806	932	27	death	death	NOUN
fnp-3806	932	28	pathways	pathway	NOUN
fnp-3806	932	29	.	.	PUNCT
fnp-3806	933	1	other	other	ADJ
fnp-3806	933	2	alterations	alteration	NOUN
fnp-3806	933	3	,	,	PUNCT
fnp-3806	933	4	such	such	ADJ
fnp-3806	933	5	as	as	ADP
fnp-3806	933	6	aberrant	aberrant	ADJ
fnp-3806	933	7	cell	cell	NOUN
fnp-3806	933	8	-	-	PUNCT
fnp-3806	933	9	cycle	cycle	NOUN
fnp-3806	933	10	re	re	NOUN
fnp-3806	933	11	-	-	NOUN
fnp-3806	933	12	entry	entry	NOUN
fnp-3806	933	13	,	,	PUNCT
fnp-3806	933	14	energy	energy	NOUN
fnp-3806	933	15	metabolism	metabolism	NOUN
fnp-3806	933	16	failure	failure	NOUN
fnp-3806	933	17	,	,	PUNCT
fnp-3806	933	18	oxidative	oxidative	ADJ
fnp-3806	933	19	stress	stress	NOUN
fnp-3806	933	20	damage	damage	NOUN
fnp-3806	933	21	,	,	PUNCT
fnp-3806	933	22	and	and	CCONJ
fnp-3806	933	23	altered	alter	VERB
fnp-3806	933	24	cell	cell	NOUN
fnp-3806	933	25	membrane	membrane	NOUN
fnp-3806	933	26	signaling	signal	VERB
fnp-3806	933	27	,	,	PUNCT
fnp-3806	933	28	are	be	AUX
fnp-3806	933	29	relevant	relevant	ADJ
fnp-3806	933	30	contributory	contributory	NOUN
fnp-3806	933	31	factors	factor	NOUN
fnp-3806	933	32	(	(	PUNCT
fnp-3806	933	33	see	see	VERB
fnp-3806	933	34	section	section	NOUN
fnp-3806	933	35	21	21	NUM
fnp-3806	933	36	)	)	PUNCT
fnp-3806	933	37	.	.	PUNCT
fnp-3806	934	1	19	19	NUM
fnp-3806	934	2	.	.	PUNCT
fnp-3806	934	3	neuronal	neuronal	ADJ
fnp-3806	934	4	connectivity	connectivity	NOUN
fnp-3806	934	5	networks	network	NOUN
fnp-3806	934	6	in	in	ADP
fnp-3806	934	7	brain	brain	NOUN
fnp-3806	934	8	aging	aging	NOUN
fnp-3806	934	9	and	and	CCONJ
fnp-3806	934	10	sad	sad	ADJ
fnp-3806	934	11	the	the	DET
fnp-3806	934	12	notion	notion	NOUN
fnp-3806	934	13	that	that	SCONJ
fnp-3806	934	14	clinical	clinical	ADJ
fnp-3806	934	15	manifestations	manifestation	NOUN
fnp-3806	934	16	in	in	ADP
fnp-3806	934	17	brain	brain	NOUN
fnp-3806	934	18	aging	aging	NOUN
fnp-3806	934	19	may	may	AUX
fnp-3806	934	20	correspond	correspond	VERB
fnp-3806	934	21	solely	solely	ADV
fnp-3806	934	22	to	to	ADP
fnp-3806	934	23	early	early	ADJ
fnp-3806	934	24	stages	stage	NOUN
fnp-3806	934	25	of	of	ADP
fnp-3806	934	26	ad	ad	NOUN
fnp-3806	934	27	-	-	PUNCT
fnp-3806	934	28	related	relate	VERB
fnp-3806	934	29	pathology	pathology	NOUN
fnp-3806	934	30	restricted	restrict	VERB
fnp-3806	934	31	to	to	ADP
fnp-3806	934	32	the	the	DET
fnp-3806	934	33	hippocampus	hippocampus	NOUN
fnp-3806	934	34	,	,	PUNCT
fnp-3806	934	35	inner	inner	ADJ
fnp-3806	934	36	regions	region	NOUN
fnp-3806	934	37	of	of	ADP
fnp-3806	934	38	the	the	DET
fnp-3806	934	39	temporal	temporal	ADJ
fnp-3806	934	40	cortex	cortex	NOUN
fnp-3806	934	41	and	and	CCONJ
fnp-3806	934	42	selected	select	VERB
fnp-3806	934	43	nuclei	nucleus	NOUN
fnp-3806	934	44	of	of	ADP
fnp-3806	934	45	the	the	DET
fnp-3806	934	46	brain	brain	NOUN
fnp-3806	934	47	stem	stem	NOUN
fnp-3806	934	48	is	be	AUX
fnp-3806	934	49	simplistic	simplistic	ADJ
fnp-3806	934	50	,	,	PUNCT
fnp-3806	934	51	and	and	CCONJ
fnp-3806	934	52	probably	probably	ADV
fnp-3806	934	53	untrue	untrue	ADJ
fnp-3806	934	54	.	.	PUNCT
fnp-3806	935	1	functional	functional	ADJ
fnp-3806	935	2	neuroimaging	neuroimaging	NOUN
fnp-3806	935	3	techniques	technique	NOUN
fnp-3806	935	4	have	have	AUX
fnp-3806	935	5	shown	show	VERB
fnp-3806	935	6	selective	selective	ADJ
fnp-3806	935	7	modifications	modification	NOUN
fnp-3806	935	8	of	of	ADP
fnp-3806	935	9	the	the	DET
fnp-3806	935	10	intrinsic	intrinsic	ADJ
fnp-3806	935	11	connectivity	connectivity	NOUN
fnp-3806	935	12	network	network	NOUN
fnp-3806	935	13	in	in	ADP
fnp-3806	935	14	aging	aging	NOUN
fnp-3806	935	15	that	that	PRON
fnp-3806	935	16	exceed	exceed	VERB
fnp-3806	935	17	the	the	DET
fnp-3806	935	18	domains	domain	NOUN
fnp-3806	935	19	of	of	ADP
fnp-3806	935	20	these	these	DET
fnp-3806	935	21	regions	region	NOUN
fnp-3806	935	22	.	.	PUNCT
fnp-3806	936	1	the	the	DET
fnp-3806	936	2	default	default	NOUN
fnp-3806	936	3	mode	mode	NOUN
fnp-3806	936	4	,	,	PUNCT
fnp-3806	936	5	salience	salience	NOUN
fnp-3806	936	6	,	,	PUNCT
fnp-3806	936	7	dorsal	dorsal	NOUN
fnp-3806	936	8	attention	attention	NOUN
fnp-3806	936	9	,	,	PUNCT
fnp-3806	936	10	fronto	fronto	NOUN
fnp-3806	936	11	-	-	PUNCT
fnp-3806	936	12	parietal	parietal	ADJ
fnp-3806	936	13	control	control	NOUN
fnp-3806	936	14	,	,	PUNCT
fnp-3806	936	15	and	and	CCONJ
fnp-3806	936	16	auditory	auditory	ADJ
fnp-3806	936	17	,	,	PUNCT
fnp-3806	936	18	visual	visual	ADJ
fnp-3806	936	19	and	and	CCONJ
fnp-3806	936	20	motor	motor	NOUN
fnp-3806	936	21	networks	network	NOUN
fnp-3806	936	22	decline	decline	VERB
fnp-3806	936	23	by	by	ADP
fnp-3806	936	24	middle	middle	ADJ
fnp-3806	936	25	adulthood	adulthood	NOUN
fnp-3806	936	26	,	,	PUNCT
fnp-3806	936	27	but	but	CCONJ
fnp-3806	936	28	the	the	DET
fnp-3806	936	29	motor	motor	NOUN
fnp-3806	936	30	network	network	NOUN
fnp-3806	936	31	shows	show	VERB
fnp-3806	936	32	increased	increase	VERB
fnp-3806	936	33	connectivity	connectivity	NOUN
fnp-3806	936	34	in	in	ADP
fnp-3806	936	35	middle	middle	ADJ
fnp-3806	936	36	adulthood	adulthood	NOUN
fnp-3806	936	37	,	,	PUNCT
fnp-3806	936	38	followed	follow	VERB
fnp-3806	936	39	by	by	ADP
fnp-3806	936	40	a	a	DET
fnp-3806	936	41	lessening	lessening	NOUN
fnp-3806	936	42	(	(	PUNCT
fnp-3806	936	43	1233	1233	NUM
fnp-3806	936	44	-	-	SYM
fnp-3806	936	45	1237	1237	NUM
fnp-3806	936	46	)	)	PUNCT
fnp-3806	936	47	.	.	PUNCT
fnp-3806	937	1	disruption	disruption	NOUN
fnp-3806	937	2	of	of	ADP
fnp-3806	937	3	neuronal	neuronal	ADJ
fnp-3806	937	4	connectivity	connectivity	NOUN
fnp-3806	937	5	networks	network	NOUN
fnp-3806	937	6	appears	appear	VERB
fnp-3806	937	7	in	in	ADP
fnp-3806	937	8	aging	aging	NOUN
fnp-3806	937	9	and	and	CCONJ
fnp-3806	937	10	is	be	AUX
fnp-3806	937	11	intensified	intensify	VERB
fnp-3806	937	12	in	in	ADP
fnp-3806	937	13	ad	ad	NOUN
fnp-3806	937	14	(	(	PUNCT
fnp-3806	937	15	1237	1237	NUM
fnp-3806	937	16	-	-	SYM
fnp-3806	937	17	1243	1243	NUM
fnp-3806	937	18	)	)	PUNCT
fnp-3806	937	19	.	.	PUNCT
fnp-3806	938	1	however	however	ADV
fnp-3806	938	2	,	,	PUNCT
fnp-3806	938	3	functional	functional	ADJ
fnp-3806	938	4	connectivity	connectivity	NOUN
fnp-3806	938	5	alterations	alteration	NOUN
fnp-3806	938	6	do	do	AUX
fnp-3806	938	7	not	not	PART
fnp-3806	938	8	always	always	ADV
fnp-3806	938	9	correlate	correlate	VERB
fnp-3806	938	10	locally	locally	ADV
fnp-3806	938	11	to	to	ADP
fnp-3806	938	12	tau	tau	PROPN
fnp-3806	938	13	and	and	CCONJ
fnp-3806	938	14	β	β	NOUN
fnp-3806	938	15	-	-	ADJ
fnp-3806	938	16	amyloid	amyloid	NOUN
fnp-3806	938	17	deposition	deposition	NOUN
fnp-3806	938	18	;	;	PUNCT
fnp-3806	938	19	hyperand	hyperand	NOUN
fnp-3806	938	20	hypo	hypo	ADJ
fnp-3806	938	21	-	-	PUNCT
fnp-3806	938	22	connectivity	connectivity	NOUN
fnp-3806	938	23	cycles	cycle	NOUN
fnp-3806	938	24	can	can	AUX
fnp-3806	938	25	occur	occur	VERB
fnp-3806	938	26	repeatedly	repeatedly	ADV
fnp-3806	938	27	at	at	ADP
fnp-3806	938	28	different	different	ADJ
fnp-3806	938	29	stages	stage	NOUN
fnp-3806	938	30	of	of	ADP
fnp-3806	938	31	the	the	DET
fnp-3806	938	32	disease	disease	NOUN
fnp-3806	938	33	(	(	PUNCT
fnp-3806	938	34	1244	1244	NUM
fnp-3806	938	35	)	)	PUNCT
fnp-3806	938	36	.	.	PUNCT
fnp-3806	939	1	moreover	moreover	ADV
fnp-3806	939	2	,	,	PUNCT
fnp-3806	939	3	greater	great	ADJ
fnp-3806	939	4	segregation	segregation	NOUN
fnp-3806	939	5	of	of	ADP
fnp-3806	939	6	functional	functional	ADJ
fnp-3806	939	7	connections	connection	NOUN
fnp-3806	939	8	into	into	ADP
fnp-3806	939	9	distinct	distinct	ADJ
fnp-3806	939	10	large	large	ADJ
fnp-3806	939	11	-	-	PUNCT
fnp-3806	939	12	scale	scale	NOUN
fnp-3806	939	13	networks	network	NOUN
fnp-3806	939	14	is	be	AUX
fnp-3806	939	15	associated	associate	VERB
fnp-3806	939	16	with	with	ADP
fnp-3806	939	17	cognitive	cognitive	ADJ
fnp-3806	939	18	resilience	resilience	NOUN
fnp-3806	939	19	at	at	ADP
fnp-3806	939	20	early	early	ADJ
fnp-3806	939	21	stages	stage	NOUN
fnp-3806	939	22	of	of	ADP
fnp-3806	939	23	sad	sad	ADJ
fnp-3806	939	24	(	(	PUNCT
fnp-3806	939	25	1245	1245	NUM
fnp-3806	939	26	,	,	PUNCT
fnp-3806	939	27	1246	1246	NUM
fnp-3806	939	28	)	)	PUNCT
fnp-3806	939	29	.	.	PUNCT
fnp-3806	940	1	additional	additional	ADJ
fnp-3806	940	2	studies	study	NOUN
fnp-3806	940	3	suggest	suggest	VERB
fnp-3806	940	4	a	a	DET
fnp-3806	940	5	compensation	compensation	NOUN
fnp-3806	940	6	phase	phase	NOUN
fnp-3806	940	7	followed	follow	VERB
fnp-3806	940	8	by	by	ADP
fnp-3806	940	9	a	a	DET
fnp-3806	940	10	degenerative	degenerative	ADJ
fnp-3806	940	11	phase	phase	NOUN
fnp-3806	940	12	in	in	ADP
fnp-3806	940	13	aging	aging	NOUN
fnp-3806	940	14	,	,	PUNCT
fnp-3806	940	15	and	and	CCONJ
fnp-3806	940	16	in	in	ADP
fnp-3806	940	17	early	early	ADJ
fnp-3806	940	18	,	,	PUNCT
fnp-3806	940	19	preclinical	preclinical	ADJ
fnp-3806	940	20	ad	ad	NOUN
fnp-3806	940	21	(	(	PUNCT
fnp-3806	940	22	1247	1247	NUM
fnp-3806	940	23	)	)	PUNCT
fnp-3806	940	24	.	.	PUNCT
fnp-3806	941	1	this	this	PRON
fnp-3806	941	2	is	be	AUX
fnp-3806	941	3	important	important	ADJ
fnp-3806	941	4	information	information	NOUN
fnp-3806	941	5	,	,	PUNCT
fnp-3806	941	6	as	as	SCONJ
fnp-3806	941	7	plasticity	plasticity	NOUN
fnp-3806	941	8	changes	change	NOUN
fnp-3806	941	9	may	may	AUX
fnp-3806	941	10	circumvent	circumvent	VERB
fnp-3806	941	11	,	,	PUNCT
fnp-3806	941	12	at	at	ADP
fnp-3806	941	13	least	least	ADJ
fnp-3806	941	14	temporarily	temporarily	ADV
fnp-3806	941	15	,	,	PUNCT
fnp-3806	941	16	deficient	deficient	ADJ
fnp-3806	941	17	functioning	function	VERB
fnp-3806	941	18	during	during	ADP
fnp-3806	941	19	brain	brain	NOUN
fnp-3806	941	20	aging	aging	NOUN
fnp-3806	941	21	and	and	CCONJ
fnp-3806	941	22	early	early	ADJ
fnp-3806	941	23	stages	stage	NOUN
fnp-3806	941	24	of	of	ADP
fnp-3806	941	25	sad	sad	ADJ
fnp-3806	941	26	.	.	PUNCT
fnp-3806	942	1	plasticity	plasticity	NOUN
fnp-3806	942	2	may	may	AUX
fnp-3806	942	3	explain	explain	VERB
fnp-3806	942	4	the	the	DET
fnp-3806	942	5	particular	particular	ADJ
fnp-3806	942	6	capacities	capacity	NOUN
fnp-3806	942	7	of	of	ADP
fnp-3806	942	8	the	the	DET
fnp-3806	942	9	adult	adult	NOUN
fnp-3806	942	10	brain	brain	NOUN
fnp-3806	942	11	to	to	PART
fnp-3806	942	12	manage	manage	VERB
fnp-3806	942	13	information	information	NOUN
fnp-3806	942	14	in	in	ADP
fnp-3806	942	15	creating	create	VERB
fnp-3806	942	16	new	new	ADJ
fnp-3806	942	17	networks	network	NOUN
fnp-3806	942	18	,	,	PUNCT
fnp-3806	942	19	manifested	manifest	VERB
fnp-3806	942	20	as	as	ADP
fnp-3806	942	21	“	"	PUNCT
fnp-3806	942	22	experience	experience	NOUN
fnp-3806	942	23	”	"	PUNCT
fnp-3806	942	24	.	.	PUNCT
fnp-3806	943	1	considering	consider	VERB
fnp-3806	943	2	the	the	DET
fnp-3806	943	3	areas	area	NOUN
fnp-3806	943	4	affected	affect	VERB
fnp-3806	943	5	in	in	ADP
fnp-3806	943	6	functional	functional	ADJ
fnp-3806	943	7	neuroimaging	neuroimaging	ADJ
fnp-3806	943	8	studies	study	NOUN
fnp-3806	943	9	,	,	PUNCT
fnp-3806	943	10	it	it	PRON
fnp-3806	943	11	may	may	AUX
fnp-3806	943	12	be	be	AUX
fnp-3806	943	13	inferred	infer	VERB
fnp-3806	943	14	that	that	SCONJ
fnp-3806	943	15	molecular	molecular	ADJ
fnp-3806	943	16	changes	change	NOUN
fnp-3806	943	17	take	take	VERB
fnp-3806	943	18	place	place	NOUN
fnp-3806	943	19	in	in	ADP
fnp-3806	943	20	the	the	DET
fnp-3806	943	21	aging	age	VERB
fnp-3806	943	22	brain	brain	NOUN
fnp-3806	943	23	in	in	ADP
fnp-3806	943	24	regions	region	NOUN
fnp-3806	943	25	other	other	ADJ
fnp-3806	943	26	than	than	ADP
fnp-3806	943	27	those	those	PRON
fnp-3806	943	28	affected	affect	VERB
fnp-3806	943	29	by	by	ADP
fnp-3806	943	30	tau	tau	PROPN
fnp-3806	943	31	and	and	CCONJ
fnp-3806	943	32	β	β	NOUN
fnp-3806	943	33	-	-	ADJ
fnp-3806	943	34	amyloid	amyloid	ADJ
fnp-3806	943	35	pathology	pathology	NOUN
fnp-3806	943	36	.	.	PUNCT
fnp-3806	944	1	20	20	NUM
fnp-3806	944	2	.	.	PUNCT
fnp-3806	944	3	human	human	ADJ
fnp-3806	944	4	brain	brain	NOUN
fnp-3806	944	5	aging	aging	NOUN
fnp-3806	944	6	and	and	CCONJ
fnp-3806	944	7	preclinical	preclinical	ADJ
fnp-3806	944	8	ad	ad	NOUN
fnp-3806	944	9	the	the	DET
fnp-3806	944	10	combination	combination	NOUN
fnp-3806	944	11	of	of	ADP
fnp-3806	944	12	clinical	clinical	ADJ
fnp-3806	944	13	manifestations	manifestation	NOUN
fnp-3806	944	14	and	and	CCONJ
fnp-3806	944	15	complementary	complementary	ADJ
fnp-3806	944	16	biomarkers	biomarker	NOUN
fnp-3806	944	17	has	have	AUX
fnp-3806	944	18	established	establish	VERB
fnp-3806	944	19	consensus	consensus	NOUN
fnp-3806	944	20	criteria	criterion	NOUN
fnp-3806	944	21	to	to	PART
fnp-3806	944	22	define	define	VERB
fnp-3806	944	23	different	different	ADJ
fnp-3806	944	24	clinical	clinical	ADJ
fnp-3806	944	25	phases	phase	NOUN
fnp-3806	944	26	of	of	ADP
fnp-3806	944	27	ad	ad	NOUN
fnp-3806	944	28	(	(	PUNCT
fnp-3806	944	29	see	see	VERB
fnp-3806	944	30	box	box	PROPN
fnp-3806	944	31	1	1	NUM
fnp-3806	944	32	)	)	PUNCT
fnp-3806	944	33	.	.	PUNCT
fnp-3806	945	1	at	at	ADP
fnp-3806	945	2	preclinical	preclinical	ADJ
fnp-3806	945	3	stages	stage	NOUN
fnp-3806	945	4	,	,	PUNCT
fnp-3806	945	5	individuals	individual	NOUN
fnp-3806	945	6	may	may	AUX
fnp-3806	945	7	have	have	VERB
fnp-3806	945	8	measurable	measurable	ADJ
fnp-3806	945	9	brain	brain	NOUN
fnp-3806	945	10	changes	change	NOUN
fnp-3806	945	11	that	that	PRON
fnp-3806	945	12	indicate	indicate	VERB
fnp-3806	945	13	the	the	DET
fnp-3806	945	14	earliest	early	ADJ
fnp-3806	945	15	signs	sign	NOUN
fnp-3806	945	16	of	of	ADP
fnp-3806	945	17	ad	ad	NOUN
fnp-3806	945	18	(	(	PUNCT
fnp-3806	945	19	biomarkers	biomarker	NOUN
fnp-3806	945	20	)	)	PUNCT
fnp-3806	945	21	,	,	PUNCT
fnp-3806	945	22	but	but	CCONJ
fnp-3806	945	23	they	they	PRON
fnp-3806	945	24	have	have	AUX
fnp-3806	945	25	not	not	PART
fnp-3806	945	26	yet	yet	ADV
fnp-3806	945	27	developed	develop	VERB
fnp-3806	945	28	symptoms	symptom	NOUN
fnp-3806	945	29	such	such	ADJ
fnp-3806	945	30	as	as	ADP
fnp-3806	945	31	memory	memory	NOUN
fnp-3806	945	32	loss	loss	NOUN
fnp-3806	945	33	(	(	PUNCT
fnp-3806	945	34	https://www.alz.org/media/documents/alzheimers-facts-and-figures.pdf	https://www.alz.org/media/documents/alzheimers-facts-and-figures.pdf	PROPN
fnp-3806	945	35	)	)	PUNCT
fnp-3806	945	36	.	.	PUNCT
fnp-3806	946	1	the	the	DET
fnp-3806	946	2	preclinical	preclinical	ADJ
fnp-3806	946	3	phase	phase	NOUN
fnp-3806	946	4	is	be	AUX
fnp-3806	946	5	further	far	ADV
fnp-3806	946	6	categorized	categorize	VERB
fnp-3806	946	7	into	into	ADP
fnp-3806	946	8	three	three	NUM
fnp-3806	946	9	stages	stage	NOUN
fnp-3806	946	10	.	.	PUNCT
fnp-3806	947	1	preclinical	preclinical	ADJ
fnp-3806	947	2	ad	ad	NOUN
fnp-3806	947	3	stage	stage	NOUN
fnp-3806	947	4	1	1	NUM
fnp-3806	947	5	includes	include	VERB
fnp-3806	947	6	cognitively	cognitively	ADV
fnp-3806	947	7	normal	normal	ADJ
fnp-3806	947	8	individuals	individual	NOUN
fnp-3806	947	9	with	with	ADP
fnp-3806	947	10	abnormal	abnormal	ADJ
fnp-3806	947	11	β	β	NOUN
fnp-3806	947	12	-	-	ADJ
fnp-3806	947	13	amyloid	amyloid	ADJ
fnp-3806	947	14	markers	marker	NOUN
fnp-3806	947	15	and	and	CCONJ
fnp-3806	947	16	no	no	DET
fnp-3806	947	17	neurodegeneration	neurodegeneration	NOUN
fnp-3806	947	18	;	;	PUNCT
fnp-3806	947	19	stage	stage	NOUN
fnp-3806	947	20	2	2	NUM
fnp-3806	947	21	,	,	PUNCT
fnp-3806	947	22	individuals	individual	NOUN
fnp-3806	947	23	with	with	ADP
fnp-3806	947	24	abnormal	abnormal	ADJ
fnp-3806	947	25	β	β	NOUN
fnp-3806	947	26	-	-	NOUN
fnp-3806	947	27	amyloid	amyloid	NOUN
fnp-3806	947	28	and	and	CCONJ
fnp-3806	947	29	neurodegeneration	neurodegeneration	NOUN
fnp-3806	947	30	as	as	SCONJ
fnp-3806	947	31	revealed	reveal	VERB
fnp-3806	947	32	by	by	ADP
fnp-3806	947	33	magnetic	magnetic	ADJ
fnp-3806	947	34	resonance	resonance	NOUN
fnp-3806	947	35	imaging	imaging	NOUN
fnp-3806	947	36	(	(	PUNCT
fnp-3806	947	37	mri	mri	NOUN
fnp-3806	947	38	)	)	PUNCT
fnp-3806	947	39	;	;	PUNCT
fnp-3806	947	40	and	and	CCONJ
fnp-3806	947	41	stage	stage	NOUN
fnp-3806	947	42	3	3	NUM
fnp-3806	947	43	,	,	PUNCT
fnp-3806	947	44	individuals	individual	NOUN
fnp-3806	947	45	with	with	ADP
fnp-3806	947	46	abnormal	abnormal	ADJ
fnp-3806	947	47	β	β	NOUN
fnp-3806	947	48	-	-	NOUN
fnp-3806	947	49	amyloid	amyloid	ADJ
fnp-3806	947	50	deposition	deposition	NOUN
fnp-3806	947	51	and	and	CCONJ
fnp-3806	947	52	neurodegeneration	neurodegeneration	NOUN
fnp-3806	947	53	,	,	PUNCT
fnp-3806	947	54	and	and	CCONJ
fnp-3806	947	55	“	"	PUNCT
fnp-3806	947	56	subtle	subtle	ADJ
fnp-3806	947	57	”	"	PUNCT
fnp-3806	947	58	cognitive	cognitive	ADJ
fnp-3806	947	59	changes	change	NOUN
fnp-3806	947	60	(	(	PUNCT
fnp-3806	947	61	2	2	NUM
fnp-3806	947	62	,	,	PUNCT
fnp-3806	947	63	48	48	NUM
fnp-3806	947	64	,	,	PUNCT
fnp-3806	947	65	1248	1248	NUM
fnp-3806	947	66	-	-	SYM
fnp-3806	947	67	1252	1252	NUM
fnp-3806	947	68	)	)	PUNCT
fnp-3806	947	69	.	.	PUNCT
fnp-3806	948	1	the	the	DET
fnp-3806	948	2	refinement	refinement	NOUN
fnp-3806	948	3	of	of	ADP
fnp-3806	948	4	the	the	DET
fnp-3806	948	5	diagnosis	diagnosis	NOUN
fnp-3806	948	6	of	of	ADP
fnp-3806	948	7	preclinical	preclinical	ADJ
fnp-3806	948	8	stages	stage	NOUN
fnp-3806	948	9	has	have	AUX
fnp-3806	948	10	improved	improve	VERB
fnp-3806	948	11	with	with	ADP
fnp-3806	948	12	the	the	DET
fnp-3806	948	13	acquisition	acquisition	NOUN
fnp-3806	948	14	of	of	ADP
fnp-3806	948	15	new	new	ADJ
fnp-3806	948	16	neuroradiological	neuroradiological	ADJ
fnp-3806	948	17	methods	method	NOUN
fnp-3806	948	18	,	,	PUNCT
fnp-3806	948	19	and	and	CCONJ
fnp-3806	948	20	optimization	optimization	NOUN
fnp-3806	948	21	of	of	ADP
fnp-3806	948	22	csf	csf	ADJ
fnp-3806	948	23	and	and	CCONJ
fnp-3806	948	24	blood	blood	NOUN
fnp-3806	948	25	biomarkers	biomarker	NOUN
fnp-3806	948	26	(	(	PUNCT
fnp-3806	948	27	1253	1253	NUM
fnp-3806	948	28	-	-	SYM
fnp-3806	948	29	1256	1256	NUM
fnp-3806	948	30	)	)	PUNCT
fnp-3806	948	31	.	.	PUNCT
fnp-3806	949	1	however	however	ADV
fnp-3806	949	2	,	,	PUNCT
fnp-3806	949	3	improvement	improvement	NOUN
fnp-3806	949	4	in	in	ADP
fnp-3806	949	5	detection	detection	NOUN
fnp-3806	949	6	using	use	VERB
fnp-3806	949	7	csf	csf	NOUN
fnp-3806	949	8	,	,	PUNCT
fnp-3806	949	9	blood	blood	NOUN
fnp-3806	949	10	,	,	PUNCT
fnp-3806	949	11	and	and	CCONJ
fnp-3806	949	12	plasma	plasma	NOUN
fnp-3806	949	13	biomarkers	biomarker	NOUN
fnp-3806	949	14	largely	largely	ADV
fnp-3806	949	15	depends	depend	VERB
fnp-3806	949	16	on	on	ADP
fnp-3806	949	17	the	the	DET
fnp-3806	949	18	availability	availability	NOUN
fnp-3806	949	19	of	of	ADP
fnp-3806	949	20	optimized	optimize	VERB
fnp-3806	949	21	instruments	instrument	NOUN
fnp-3806	949	22	and	and	CCONJ
fnp-3806	949	23	markers	marker	NOUN
fnp-3806	949	24	.	.	PUNCT
fnp-3806	950	1	current	current	ADJ
fnp-3806	950	2	csf	csf	ADJ
fnp-3806	950	3	and	and	CCONJ
fnp-3806	950	4	plasma	plasma	NOUN
fnp-3806	950	5	biomarkers	biomarker	NOUN
fnp-3806	950	6	used	use	VERB
fnp-3806	950	7	in	in	ADP
fnp-3806	950	8	the	the	DET
fnp-3806	950	9	diagnosis	diagnosis	NOUN
fnp-3806	950	10	of	of	ADP
fnp-3806	950	11	ad	ad	NOUN
fnp-3806	950	12	are	be	AUX
fnp-3806	950	13	levels	level	NOUN
fnp-3806	950	14	of	of	ADP
fnp-3806	950	15	β	β	NOUN
fnp-3806	950	16	-	-	NOUN
fnp-3806	950	17	amyloid	amyloid	ADJ
fnp-3806	950	18	,	,	PUNCT
fnp-3806	950	19	phospho	phospho	NOUN
fnp-3806	950	20	-	-	PUNCT
fnp-3806	950	21	tau	tau	PROPN
fnp-3806	950	22	,	,	PUNCT
fnp-3806	950	23	tau	tau	PROPN
fnp-3806	950	24	,	,	PUNCT
fnp-3806	950	25	and	and	CCONJ
fnp-3806	950	26	phospho	phospho	ADJ
fnp-3806	950	27	-	-	PUNCT
fnp-3806	950	28	tau	tau	NOUN
fnp-3806	950	29	ratio	ratio	NOUN
fnp-3806	950	30	,	,	PUNCT
fnp-3806	950	31	neurofilaments	neurofilament	NOUN
fnp-3806	950	32	,	,	PUNCT
fnp-3806	950	33	synaptic	synaptic	ADJ
fnp-3806	950	34	proteins	protein	NOUN
fnp-3806	950	35	,	,	PUNCT
fnp-3806	950	36	markers	marker	NOUN
fnp-3806	950	37	of	of	ADP
fnp-3806	950	38	activated	activate	VERB
fnp-3806	950	39	astrocytes	astrocyte	NOUN
fnp-3806	950	40	,	,	PUNCT
fnp-3806	950	41	and	and	CCONJ
fnp-3806	950	42	inflammatory	inflammatory	ADJ
fnp-3806	950	43	markers	marker	NOUN
fnp-3806	950	44	.	.	PUNCT
fnp-3806	951	1	at	at	ADP
fnp-3806	951	2	present	present	ADJ
fnp-3806	951	3	,	,	PUNCT
fnp-3806	951	4	the	the	DET
fnp-3806	951	5	available	available	ADJ
fnp-3806	951	6	methods	method	NOUN
fnp-3806	951	7	can	can	AUX
fnp-3806	951	8	not	not	PART
fnp-3806	951	9	detect	detect	VERB
fnp-3806	951	10	differential	differential	ADJ
fnp-3806	951	11	levels	level	NOUN
fnp-3806	951	12	of	of	ADP
fnp-3806	951	13	tau	tau	PROPN
fnp-3806	951	14	,	,	PUNCT
fnp-3806	951	15	phospho	phospho	NOUN
fnp-3806	951	16	-	-	PUNCT
fnp-3806	951	17	tau	tau	PROPN
fnp-3806	951	18	,	,	PUNCT
fnp-3806	951	19	β	β	NOUN
fnp-3806	951	20	-	-	NOUN
fnp-3806	951	21	amyloid	amyloid	NOUN
fnp-3806	951	22	,	,	PUNCT
fnp-3806	951	23	and	and	CCONJ
fnp-3806	951	24	structural	structural	ADJ
fnp-3806	951	25	and	and	CCONJ
fnp-3806	951	26	synaptic	synaptic	ADJ
fnp-3806	951	27	proteins	protein	NOUN
fnp-3806	951	28	unless	unless	SCONJ
fnp-3806	951	29	the	the	DET
fnp-3806	951	30	degenerative	degenerative	ADJ
fnp-3806	951	31	process	process	NOUN
fnp-3806	951	32	is	be	AUX
fnp-3806	951	33	at	at	ADP
fnp-3806	951	34	least	least	ADJ
fnp-3806	951	35	at	at	ADP
fnp-3806	951	36	undetermined	undetermined	ADJ
fnp-3806	951	37	middle	middle	ADJ
fnp-3806	951	38	stages	stage	NOUN
fnp-3806	951	39	of	of	ADP
fnp-3806	951	40	ad	ad	NOUN
fnp-3806	951	41	neuropathological	neuropathological	ADJ
fnp-3806	951	42	change	change	NOUN
fnp-3806	951	43	.	.	PUNCT
fnp-3806	952	1	hippocampal	hippocampal	ADJ
fnp-3806	952	2	atrophy	atrophy	NOUN
fnp-3806	952	3	,	,	PUNCT
fnp-3806	952	4	as	as	SCONJ
fnp-3806	952	5	revealed	reveal	VERB
fnp-3806	952	6	by	by	ADP
fnp-3806	952	7	computed	compute	VERB
fnp-3806	952	8	tomography	tomography	NOUN
fnp-3806	952	9	(	(	PUNCT
fnp-3806	952	10	ct	ct	NOUN
fnp-3806	952	11	)	)	PUNCT
fnp-3806	952	12	and	and	CCONJ
fnp-3806	952	13	mri	mri	NOUN
fnp-3806	952	14	,	,	PUNCT
fnp-3806	952	15	and	and	CCONJ
fnp-3806	952	16	currently	currently	ADV
fnp-3806	952	17	used	use	VERB
fnp-3806	952	18	to	to	PART
fnp-3806	952	19	correlate	correlate	VERB
fnp-3806	952	20	cognitive	cognitive	ADJ
fnp-3806	952	21	impairment	impairment	NOUN
fnp-3806	952	22	and	and	CCONJ
fnp-3806	952	23	altered	alter	VERB
fnp-3806	952	24	neuropathological	neuropathological	ADJ
fnp-3806	952	25	substrate	substrate	NOUN
fnp-3806	952	26	,	,	PUNCT
fnp-3806	952	27	is	be	AUX
fnp-3806	952	28	a	a	DET
fnp-3806	952	29	late	late	ADJ
fnp-3806	952	30	marker	marker	NOUN
fnp-3806	952	31	of	of	ADP
fnp-3806	952	32	ad	ad	NOUN
fnp-3806	952	33	that	that	PRON
fnp-3806	952	34	is	be	AUX
fnp-3806	952	35	only	only	ADV
fnp-3806	952	36	positive	positive	ADJ
fnp-3806	952	37	when	when	SCONJ
fnp-3806	952	38	there	there	PRON
fnp-3806	952	39	is	be	VERB
fnp-3806	952	40	advanced	advanced	ADJ
fnp-3806	952	41	nft	nft	PROPN
fnp-3806	952	42	pathology	pathology	PROPN
fnp-3806	952	43	and	and	CCONJ
fnp-3806	952	44	neuron	neuron	PROPN
fnp-3806	952	45	loss	loss	NOUN
fnp-3806	952	46	in	in	ADP
fnp-3806	952	47	the	the	DET
fnp-3806	952	48	hippocampus	hippocampus	NOUN
fnp-3806	952	49	.	.	PUNCT
fnp-3806	953	1	a	a	DET
fnp-3806	953	2	recent	recent	ADJ
fnp-3806	953	3	meta	meta	ADJ
fnp-3806	953	4	-	-	PUNCT
fnp-3806	953	5	analysis	analysis	NOUN
fnp-3806	953	6	to	to	PART
fnp-3806	953	7	estimate	estimate	VERB
fnp-3806	953	8	the	the	DET
fnp-3806	953	9	prevalence	prevalence	NOUN
fnp-3806	953	10	of	of	ADP
fnp-3806	953	11	aβ	aβ	DET
fnp-3806	953	12	pathology	pathology	NOUN
fnp-3806	953	13	as	as	SCONJ
fnp-3806	953	14	measured	measure	VERB
fnp-3806	953	15	with	with	ADP
fnp-3806	953	16	biomarkers	biomarker	NOUN
fnp-3806	953	17	in	in	ADP
fnp-3806	953	18	participants	participant	NOUN
fnp-3806	953	19	with	with	ADP
fnp-3806	953	20	normal	normal	ADJ
fnp-3806	953	21	cognition	cognition	NOUN
fnp-3806	953	22	,	,	PUNCT
fnp-3806	953	23	subjective	subjective	ADJ
fnp-3806	953	24	cognitive	cognitive	ADJ
fnp-3806	953	25	impairment	impairment	NOUN
fnp-3806	953	26	,	,	PUNCT
fnp-3806	953	27	or	or	CCONJ
fnp-3806	953	28	mild	mild	ADJ
fnp-3806	953	29	cognitive	cognitive	ADJ
fnp-3806	953	30	impairment	impairment	NOUN
fnp-3806	953	31	revealed	reveal	VERB
fnp-3806	953	32	that	that	SCONJ
fnp-3806	953	33	about	about	ADV
fnp-3806	953	34	25	25	NUM
fnp-3806	953	35	-	-	SYM
fnp-3806	953	36	35	35	NUM
fnp-3806	953	37	%	%	NOUN
fnp-3806	953	38	of	of	ADP
fnp-3806	953	39	cognitively	cognitively	ADV
fnp-3806	953	40	normal	normal	ADJ
fnp-3806	953	41	older	old	ADJ
fnp-3806	953	42	adults	adult	NOUN
fnp-3806	953	43	harbored	harbor	VERB
fnp-3806	953	44	a	a	DET
fnp-3806	953	45	significant	significant	ADJ
fnp-3806	953	46	amount	amount	NOUN
fnp-3806	953	47	of	of	ADP
fnp-3806	953	48	β	β	NOUN
fnp-3806	953	49	-	-	NOUN
fnp-3806	953	50	amyloid	amyloid	NOUN
fnp-3806	953	51	(	(	PUNCT
fnp-3806	953	52	1257	1257	NUM
fnp-3806	953	53	)	)	PUNCT
fnp-3806	953	54	.	.	PUNCT
fnp-3806	954	1	further	further	ADJ
fnp-3806	954	2	studies	study	NOUN
fnp-3806	954	3	have	have	AUX
fnp-3806	954	4	shown	show	VERB
fnp-3806	954	5	that	that	SCONJ
fnp-3806	954	6	β	β	NOUN
fnp-3806	954	7	-	-	ADJ
fnp-3806	954	8	amyloid	amyloid	ADJ
fnp-3806	954	9	csf	csf	NOUN
fnp-3806	954	10	-	-	PUNCT
fnp-3806	954	11	based	base	VERB
fnp-3806	954	12	estimates	estimate	NOUN
fnp-3806	954	13	using	use	VERB
fnp-3806	954	14	adjusted	adjusted	ADJ
fnp-3806	954	15	data	data	NOUN
fnp-3806	954	16	-	-	PUNCT
fnp-3806	954	17	driven	drive	VERB
fnp-3806	954	18	cutoffs	cutoff	NOUN
fnp-3806	954	19	are	be	AUX
fnp-3806	954	20	up	up	ADP
fnp-3806	954	21	to	to	PART
fnp-3806	954	22	10	10	NUM
fnp-3806	954	23	%	%	NOUN
fnp-3806	954	24	higher	high	ADJ
fnp-3806	954	25	than	than	ADP
fnp-3806	954	26	pet	pet	NOUN
fnp-3806	954	27	-	-	PUNCT
fnp-3806	954	28	based	base	VERB
fnp-3806	954	29	estimates	estimate	NOUN
fnp-3806	954	30	in	in	ADP
fnp-3806	954	31	people	people	NOUN
fnp-3806	954	32	without	without	ADP
fnp-3806	954	33	dementia	dementia	NOUN
fnp-3806	954	34	thus	thus	ADV
fnp-3806	954	35	suggesting	suggest	VERB
fnp-3806	954	36	that	that	SCONJ
fnp-3806	954	37	preclinical	preclinical	ADJ
fnp-3806	954	38	ad	ad	NOUN
fnp-3806	954	39	may	may	AUX
fnp-3806	954	40	be	be	AUX
fnp-3806	954	41	more	more	ADV
fnp-3806	954	42	prevalent	prevalent	ADJ
fnp-3806	954	43	than	than	ADP
fnp-3806	954	44	previously	previously	ADV
fnp-3806	954	45	suspected	suspect	VERB
fnp-3806	954	46	(	(	PUNCT
fnp-3806	954	47	1258	1258	NUM
fnp-3806	954	48	)	)	PUNCT
fnp-3806	954	49	.	.	PUNCT
fnp-3806	955	1	in	in	ADP
fnp-3806	955	2	contrast	contrast	NOUN
fnp-3806	955	3	,	,	PUNCT
fnp-3806	955	4	tau	tau	PROPN
fnp-3806	955	5	pet	pet	ADJ
fnp-3806	955	6	imaging	imaging	NOUN
fnp-3806	955	7	using	use	VERB
fnp-3806	955	8	optimized	optimize	VERB
fnp-3806	955	9	tracers	tracer	NOUN
fnp-3806	955	10	provides	provide	VERB
fnp-3806	955	11	more	more	ADV
fnp-3806	955	12	precise	precise	ADJ
fnp-3806	955	13	information	information	NOUN
fnp-3806	955	14	in	in	ADP
fnp-3806	955	15	vivo	vivo	NOUN
fnp-3806	955	16	at	at	ADP
fnp-3806	955	17	the	the	DET
fnp-3806	955	18	different	different	ADJ
fnp-3806	955	19	stages	stage	NOUN
fnp-3806	955	20	of	of	ADP
fnp-3806	955	21	nft	nft	PROPN
fnp-3806	955	22	progression	progression	NOUN
fnp-3806	955	23	(	(	PUNCT
fnp-3806	955	24	855	855	NUM
fnp-3806	955	25	,	,	PUNCT
fnp-3806	955	26	1259	1259	NUM
fnp-3806	955	27	-	-	SYM
fnp-3806	955	28	1267	1267	NUM
fnp-3806	955	29	)	)	PUNCT
fnp-3806	955	30	.	.	PUNCT
fnp-3806	956	1	improved	improve	VERB
fnp-3806	956	2	neuroimaging	neuroimaging	NOUN
fnp-3806	956	3	methods	method	NOUN
fnp-3806	956	4	corroborate	corroborate	VERB
fnp-3806	956	5	earlier	early	ADJ
fnp-3806	956	6	neuropathological	neuropathological	ADJ
fnp-3806	956	7	observations	observation	NOUN
fnp-3806	956	8	in	in	ADP
fnp-3806	956	9	post	post	ADJ
fnp-3806	956	10	-	-	ADJ
fnp-3806	956	11	mortem	mortem	ADJ
fnp-3806	956	12	brains	brain	NOUN
fnp-3806	956	13	.	.	PUNCT
fnp-3806	957	1	individuals	individual	NOUN
fnp-3806	957	2	without	without	ADP
fnp-3806	957	3	cognitive	cognitive	ADJ
fnp-3806	957	4	impairment	impairment	NOUN
fnp-3806	957	5	may	may	AUX
fnp-3806	957	6	have	have	VERB
fnp-3806	957	7	tau	tau	PROPN
fnp-3806	957	8	or	or	CCONJ
fnp-3806	957	9	β	β	NOUN
fnp-3806	957	10	-	-	ADJ
fnp-3806	957	11	amyloid	amyloid	ADJ
fnp-3806	957	12	positive	positive	ADJ
fnp-3806	957	13	signal	signal	NOUN
fnp-3806	957	14	alone	alone	ADV
fnp-3806	957	15	,	,	PUNCT
fnp-3806	957	16	or	or	CCONJ
fnp-3806	957	17	β	β	X
fnp-3806	957	18	-	-	NOUN
fnp-3806	957	19	amyloid	amyloid	NOUN
fnp-3806	957	20	and	and	CCONJ
fnp-3806	957	21	tau	tau	PROPN
fnp-3806	957	22	pathology	pathology	NOUN
fnp-3806	957	23	,	,	PUNCT
fnp-3806	957	24	or	or	CCONJ
fnp-3806	957	25	tau	tau	PROPN
fnp-3806	957	26	and	and	CCONJ
fnp-3806	957	27	β	β	NOUN
fnp-3806	957	28	-	-	ADJ
fnp-3806	957	29	amyloid	amyloid	ADJ
fnp-3806	957	30	pet	pet	NOUN
fnp-3806	957	31	negativity	negativity	NOUN
fnp-3806	957	32	(	(	PUNCT
fnp-3806	957	33	1268	1268	NUM
fnp-3806	957	34	-	-	SYM
fnp-3806	957	35	1270	1270	NUM
fnp-3806	957	36	)	)	PUNCT
fnp-3806	957	37	.	.	PUNCT
fnp-3806	958	1	neuroimaging	neuroimage	VERB
fnp-3806	958	2	studies	study	NOUN
fnp-3806	958	3	have	have	AUX
fnp-3806	958	4	also	also	ADV
fnp-3806	958	5	identified	identify	VERB
fnp-3806	958	6	tau	tau	PROPN
fnp-3806	958	7	pathology	pathology	NOUN
fnp-3806	958	8	in	in	ADP
fnp-3806	958	9	the	the	DET
fnp-3806	958	10	entorhinal	entorhinal	ADJ
fnp-3806	958	11	region	region	NOUN
fnp-3806	958	12	and	and	CCONJ
fnp-3806	958	13	mesial	mesial	ADJ
fnp-3806	958	14	temporal	temporal	ADJ
fnp-3806	958	15	cortex	cortex	NOUN
fnp-3806	958	16	in	in	ADP
fnp-3806	958	17	normal	normal	ADJ
fnp-3806	958	18	aged	aged	ADJ
fnp-3806	958	19	individuals	individual	NOUN
fnp-3806	958	20	with	with	ADP
fnp-3806	958	21	or	or	CCONJ
fnp-3806	958	22	without	without	ADP
fnp-3806	958	23	minimal	minimal	ADJ
fnp-3806	958	24	cognitive	cognitive	ADJ
fnp-3806	958	25	impairment	impairment	NOUN
fnp-3806	958	26	(	(	PUNCT
fnp-3806	958	27	1271	1271	NUM
fnp-3806	958	28	-	-	SYM
fnp-3806	958	29	1276	1276	NUM
fnp-3806	958	30	)	)	PUNCT
fnp-3806	958	31	.	.	PUNCT
fnp-3806	959	1	tau	tau	PROPN
fnp-3806	959	2	pet	pet	ADJ
fnp-3806	959	3	observations	observation	NOUN
fnp-3806	959	4	are	be	AUX
fnp-3806	959	5	also	also	ADV
fnp-3806	959	6	useful	useful	ADJ
fnp-3806	959	7	to	to	PART
fnp-3806	959	8	show	show	VERB
fnp-3806	959	9	that	that	SCONJ
fnp-3806	959	10	tau	tau	PROPN
fnp-3806	959	11	deposits	deposit	NOUN
fnp-3806	959	12	appear	appear	VERB
fnp-3806	959	13	before	before	ADP
fnp-3806	959	14	β	β	NOUN
fnp-3806	959	15	-	-	NOUN
fnp-3806	959	16	amyloid	amyloid	ADJ
fnp-3806	959	17	deposits	deposit	NOUN
fnp-3806	959	18	in	in	ADP
fnp-3806	959	19	most	most	ADJ
fnp-3806	959	20	individuals	individual	NOUN
fnp-3806	959	21	.	.	PUNCT
fnp-3806	960	1	finally	finally	ADV
fnp-3806	960	2	,	,	PUNCT
fnp-3806	960	3	neuroimaging	neuroimaging	NOUN
fnp-3806	960	4	allows	allow	VERB
fnp-3806	960	5	the	the	DET
fnp-3806	960	6	visualization	visualization	NOUN
fnp-3806	960	7	of	of	ADP
fnp-3806	960	8	a	a	DET
fnp-3806	960	9	continuum	continuum	NOUN
fnp-3806	960	10	of	of	ADP
fnp-3806	960	11	lesions	lesion	NOUN
fnp-3806	960	12	from	from	ADP
fnp-3806	960	13	“	"	PUNCT
fnp-3806	960	14	normal	normal	ADJ
fnp-3806	960	15	”	"	PUNCT
fnp-3806	960	16	brain	brain	NOUN
fnp-3806	960	17	aging	aging	NOUN
fnp-3806	960	18	to	to	ADP
fnp-3806	960	19	alzheimer	alzheimer	PROPN
fnp-3806	960	20	’s	’s	PART
fnp-3806	960	21	type	type	NOUN
fnp-3806	960	22	dementia	dementia	NOUN
fnp-3806	960	23	in	in	ADP
fnp-3806	960	24	sad	sad	ADJ
fnp-3806	960	25	and	and	CCONJ
fnp-3806	960	26	fad	fad	NOUN
fnp-3806	960	27	(	(	PUNCT
fnp-3806	960	28	1277	1277	NUM
fnp-3806	960	29	,	,	PUNCT
fnp-3806	960	30	1278	1278	NUM
fnp-3806	960	31	)	)	PUNCT
fnp-3806	960	32	.	.	PUNCT
fnp-3806	961	1	therefore	therefore	ADV
fnp-3806	961	2	,	,	PUNCT
fnp-3806	961	3	neuroimaging	neuroimaging	NOUN
fnp-3806	961	4	observations	observation	NOUN
fnp-3806	961	5	further	far	ADV
fnp-3806	961	6	suggest	suggest	VERB
fnp-3806	961	7	that	that	SCONJ
fnp-3806	961	8	tau	tau	PROPN
fnp-3806	961	9	pathology	pathology	NOUN
fnp-3806	961	10	is	be	AUX
fnp-3806	961	11	predominant	predominant	ADJ
fnp-3806	961	12	in	in	ADP
fnp-3806	961	13	normal	normal	ADJ
fnp-3806	961	14	brain	brain	NOUN
fnp-3806	961	15	aging	aging	NOUN
fnp-3806	961	16	that	that	PRON
fnp-3806	961	17	overlaps	overlap	VERB
fnp-3806	961	18	with	with	ADP
fnp-3806	961	19	tau	tau	PROPN
fnp-3806	961	20	pathology	pathology	NOUN
fnp-3806	961	21	in	in	ADP
fnp-3806	961	22	individuals	individual	NOUN
fnp-3806	961	23	with	with	ADP
fnp-3806	961	24	preclinical	preclinical	ADJ
fnp-3806	961	25	ad	ad	NOUN
fnp-3806	961	26	.	.	PUNCT
fnp-3806	962	1	clinical	clinical	ADJ
fnp-3806	962	2	criteria	criterion	NOUN
fnp-3806	962	3	of	of	ADP
fnp-3806	962	4	ad	ad	NOUN
fnp-3806	962	5	are	be	AUX
fnp-3806	962	6	biased	bias	VERB
fnp-3806	962	7	by	by	ADP
fnp-3806	962	8	the	the	DET
fnp-3806	962	9	consideration	consideration	NOUN
fnp-3806	962	10	that	that	PRON
fnp-3806	962	11	aβ	aβ	DET
fnp-3806	962	12	pathology	pathology	NOUN
fnp-3806	962	13	precedes	precede	VERB
fnp-3806	962	14	tau	tau	PROPN
fnp-3806	962	15	pathology	pathology	NOUN
fnp-3806	962	16	in	in	ADP
fnp-3806	962	17	sad	sad	ADJ
fnp-3806	962	18	.	.	PUNCT
fnp-3806	963	1	in	in	ADP
fnp-3806	963	2	other	other	ADJ
fnp-3806	963	3	words	word	NOUN
fnp-3806	963	4	,	,	PUNCT
fnp-3806	963	5	the	the	DET
fnp-3806	963	6	conception	conception	NOUN
fnp-3806	963	7	of	of	ADP
fnp-3806	963	8	the	the	DET
fnp-3806	963	9	β	β	NOUN
fnp-3806	963	10	-	-	ADJ
fnp-3806	963	11	amyloid	amyloid	ADJ
fnp-3806	963	12	cascade	cascade	NOUN
fnp-3806	963	13	hypothesis	hypothesis	NOUN
fnp-3806	963	14	permeates	permeate	VERB
fnp-3806	963	15	the	the	DET
fnp-3806	963	16	diagnosis	diagnosis	NOUN
fnp-3806	963	17	of	of	ADP
fnp-3806	963	18	sad	sad	ADJ
fnp-3806	963	19	.	.	PUNCT
fnp-3806	964	1	in	in	ADP
fnp-3806	964	2	addition	addition	NOUN
fnp-3806	964	3	to	to	ADP
fnp-3806	964	4	clinical	clinical	ADJ
fnp-3806	964	5	and	and	CCONJ
fnp-3806	964	6	biomarker	biomarker	NOUN
fnp-3806	964	7	criteria	criterion	NOUN
fnp-3806	964	8	,	,	PUNCT
fnp-3806	964	9	new	new	ADJ
fnp-3806	964	10	neuropathological	neuropathological	ADJ
fnp-3806	964	11	standards	standard	NOUN
fnp-3806	964	12	,	,	PUNCT
fnp-3806	964	13	based	base	VERB
fnp-3806	964	14	on	on	ADP
fnp-3806	964	15	the	the	DET
fnp-3806	964	16	study	study	NOUN
fnp-3806	964	17	of	of	ADP
fnp-3806	964	18	a	a	DET
fnp-3806	964	19	wide	wide	ADJ
fnp-3806	964	20	number	number	NOUN
fnp-3806	964	21	of	of	ADP
fnp-3806	964	22	selected	select	VERB
fnp-3806	964	23	brain	brain	NOUN
fnp-3806	964	24	regions	region	NOUN
fnp-3806	964	25	stained	stain	VERB
fnp-3806	964	26	with	with	ADP
fnp-3806	964	27	selected	select	VERB
fnp-3806	964	28	immunohistochemical	immunohistochemical	ADJ
fnp-3806	964	29	markers	marker	NOUN
fnp-3806	964	30	,	,	PUNCT
fnp-3806	964	31	take	take	VERB
fnp-3806	964	32	into	into	ADP
fnp-3806	964	33	consideration	consideration	NOUN
fnp-3806	964	34	ad	ad	NOUN
fnp-3806	964	35	pathology	pathology	NOUN
fnp-3806	964	36	progression	progression	NOUN
fnp-3806	964	37	and	and	CCONJ
fnp-3806	964	38	the	the	DET
fnp-3806	964	39	presence	presence	NOUN
fnp-3806	964	40	of	of	ADP
fnp-3806	964	41	comorbid	comorbid	NOUN
fnp-3806	964	42	pathologies	pathology	NOUN
fnp-3806	964	43	were	be	AUX
fnp-3806	964	44	proposed	propose	VERB
fnp-3806	964	45	by	by	ADP
fnp-3806	964	46	the	the	DET
fnp-3806	964	47	national	national	PROPN
fnp-3806	964	48	institute	institute	PROPN
fnp-3806	964	49	on	on	ADP
fnp-3806	964	50	aging	age	VERB
fnp-3806	964	51	–	–	PUNCT
fnp-3806	964	52	alzheimer	alzheimer	PROPN
fnp-3806	964	53	’s	’s	NOUN
fnp-3806	964	54	association	association	PROPN
fnp-3806	964	55	(	(	PUNCT
fnp-3806	964	56	nia	nia	PROPN
fnp-3806	964	57	-	-	PUNCT
fnp-3806	964	58	aa	aa	NOUN
fnp-3806	964	59	)	)	PUNCT
fnp-3806	964	60	in	in	ADP
fnp-3806	964	61	2012	2012	NUM
fnp-3806	964	62	(	(	PUNCT
fnp-3806	964	63	49	49	NUM
fnp-3806	964	64	,	,	PUNCT
fnp-3806	964	65	50	50	NUM
fnp-3806	964	66	)	)	PUNCT
fnp-3806	964	67	.	.	PUNCT
fnp-3806	965	1	the	the	DET
fnp-3806	965	2	main	main	ADJ
fnp-3806	965	3	considerations	consideration	NOUN
fnp-3806	965	4	are	be	AUX
fnp-3806	965	5	a	a	DET
fnp-3806	965	6	)	)	PUNCT
fnp-3806	965	7	recognition	recognition	NOUN
fnp-3806	965	8	that	that	SCONJ
fnp-3806	965	9	ad	ad	NOUN
fnp-3806	965	10	neuropathologic	neuropathologic	NOUN
fnp-3806	965	11	changes	change	NOUN
fnp-3806	965	12	may	may	AUX
fnp-3806	965	13	occur	occur	VERB
fnp-3806	965	14	in	in	ADP
fnp-3806	965	15	the	the	DET
fnp-3806	965	16	apparent	apparent	ADJ
fnp-3806	965	17	absence	absence	NOUN
fnp-3806	965	18	of	of	ADP
fnp-3806	965	19	cognitive	cognitive	ADJ
fnp-3806	965	20	impairment	impairment	NOUN
fnp-3806	965	21	,	,	PUNCT
fnp-3806	965	22	(	(	PUNCT
fnp-3806	965	23	b	b	X
fnp-3806	965	24	)	)	PUNCT
fnp-3806	965	25	consideration	consideration	NOUN
fnp-3806	965	26	of	of	ADP
fnp-3806	965	27	an	an	DET
fnp-3806	965	28	“	"	PUNCT
fnp-3806	965	29	abc	abc	PROPN
fnp-3806	965	30	”	"	PUNCT
fnp-3806	965	31	score	score	NOUN
fnp-3806	965	32	for	for	ADP
fnp-3806	965	33	ad	ad	NOUN
fnp-3806	965	34	neuropathologic	neuropathologic	ADJ
fnp-3806	965	35	change	change	NOUN
fnp-3806	965	36	that	that	PRON
fnp-3806	965	37	incorporates	incorporate	VERB
fnp-3806	965	38	histopathologic	histopathologic	ADJ
fnp-3806	965	39	assessments	assessment	NOUN
fnp-3806	965	40	of	of	ADP
fnp-3806	965	41	β	β	NOUN
fnp-3806	965	42	-	-	ADJ
fnp-3806	965	43	amyloid	amyloid	ADJ
fnp-3806	965	44	deposits	deposit	NOUN
fnp-3806	965	45	(	(	PUNCT
fnp-3806	965	46	named	name	VERB
fnp-3806	965	47	a	a	PRON
fnp-3806	965	48	,	,	PUNCT
fnp-3806	965	49	based	base	VERB
fnp-3806	965	50	on	on	ADP
fnp-3806	965	51	thal	thal	PROPN
fnp-3806	965	52	phases	phase	NOUN
fnp-3806	965	53	)	)	PUNCT
fnp-3806	965	54	,	,	PUNCT
fnp-3806	965	55	staging	staging	NOUN
fnp-3806	965	56	of	of	ADP
fnp-3806	965	57	neurofibrillary	neurofibrillary	ADJ
fnp-3806	965	58	tangles	tangle	NOUN
fnp-3806	965	59	(	(	PUNCT
fnp-3806	965	60	named	name	VERB
fnp-3806	965	61	b	b	PROPN
fnp-3806	965	62	,	,	PUNCT
fnp-3806	965	63	based	base	VERB
fnp-3806	965	64	on	on	ADP
fnp-3806	965	65	braak	braak	PROPN
fnp-3806	965	66	stages	stage	NOUN
fnp-3806	965	67	)	)	PUNCT
fnp-3806	965	68	,	,	PUNCT
fnp-3806	965	69	and	and	CCONJ
fnp-3806	965	70	scoring	scoring	NOUN
fnp-3806	965	71	of	of	ADP
fnp-3806	965	72	neuritic	neuritic	ADJ
fnp-3806	965	73	plaques	plaque	NOUN
fnp-3806	965	74	(	(	PUNCT
fnp-3806	965	75	named	name	VERB
fnp-3806	965	76	c	c	PROPN
fnp-3806	965	77	,	,	PUNCT
fnp-3806	965	78	based	base	VERB
fnp-3806	965	79	on	on	ADP
fnp-3806	965	80	cerad	cerad	NOUN
fnp-3806	965	81	)	)	PUNCT
fnp-3806	965	82	,	,	PUNCT
fnp-3806	965	83	and	and	CCONJ
fnp-3806	965	84	(	(	PUNCT
fnp-3806	965	85	c	c	NOUN
fnp-3806	965	86	)	)	PUNCT
fnp-3806	965	87	assessment	assessment	NOUN
fnp-3806	965	88	of	of	ADP
fnp-3806	965	89	co	co	ADJ
fnp-3806	965	90	-	-	ADJ
fnp-3806	965	91	morbid	morbid	ADJ
fnp-3806	965	92	conditions	condition	NOUN
fnp-3806	965	93	such	such	ADJ
fnp-3806	965	94	as	as	ADP
fnp-3806	965	95	lewy	lewy	PROPN
fnp-3806	965	96	body	body	NOUN
fnp-3806	965	97	disease	disease	NOUN
fnp-3806	965	98	,	,	PUNCT
fnp-3806	965	99	vascular	vascular	ADJ
fnp-3806	965	100	brain	brain	NOUN
fnp-3806	965	101	injury	injury	NOUN
fnp-3806	965	102	,	,	PUNCT
fnp-3806	965	103	hippocampal	hippocampal	ADJ
fnp-3806	965	104	sclerosis	sclerosis	NOUN
fnp-3806	965	105	,	,	PUNCT
fnp-3806	965	106	and	and	CCONJ
fnp-3806	965	107	tdp-43	tdp-43	NOUN
fnp-3806	965	108	proteinopathy	proteinopathy	ADJ
fnp-3806	965	109	;	;	PUNCT
fnp-3806	965	110	also	also	ADV
fnp-3806	965	111	including	include	VERB
fnp-3806	965	112	artag	artag	NOUN
fnp-3806	965	113	and	and	CCONJ
fnp-3806	965	114	agd	agd	PROPN
fnp-3806	965	115	.	.	PUNCT
fnp-3806	966	1	at	at	ADP
fnp-3806	966	2	present	present	ADJ
fnp-3806	966	3	,	,	PUNCT
fnp-3806	966	4	the	the	DET
fnp-3806	966	5	post	post	ADJ
fnp-3806	966	6	-	-	ADJ
fnp-3806	966	7	mortem	mortem	ADJ
fnp-3806	966	8	neuropathological	neuropathological	ADJ
fnp-3806	966	9	examination	examination	NOUN
fnp-3806	966	10	is	be	AUX
fnp-3806	966	11	still	still	ADV
fnp-3806	966	12	the	the	DET
fnp-3806	966	13	most	most	ADV
fnp-3806	966	14	precise	precise	ADJ
fnp-3806	966	15	approach	approach	NOUN
fnp-3806	966	16	to	to	PART
fnp-3806	966	17	identify	identify	VERB
fnp-3806	966	18	the	the	DET
fnp-3806	966	19	morphological	morphological	ADJ
fnp-3806	966	20	changes	change	NOUN
fnp-3806	966	21	linked	link	VERB
fnp-3806	966	22	to	to	ADP
fnp-3806	966	23	a	a	DET
fnp-3806	966	24	brain	brain	NOUN
fnp-3806	966	25	aging	aging	NOUN
fnp-3806	966	26	and	and	CCONJ
fnp-3806	966	27	sad	sad	ADJ
fnp-3806	966	28	(	(	PUNCT
fnp-3806	966	29	49	49	NUM
fnp-3806	966	30	,	,	PUNCT
fnp-3806	966	31	50	50	NUM
fnp-3806	966	32	,	,	PUNCT
fnp-3806	966	33	325	325	NUM
fnp-3806	966	34	)	)	PUNCT
fnp-3806	966	35	(	(	PUNCT
fnp-3806	966	36	table	table	NOUN
fnp-3806	966	37	1	1	NUM
fnp-3806	966	38	)	)	PUNCT
fnp-3806	966	39	.	.	PUNCT
fnp-3806	967	1	“	"	PUNCT
fnp-3806	967	2	a	a	DET
fnp-3806	967	3	”	"	PUNCT
fnp-3806	967	4	thal	thal	NOUN
fnp-3806	967	5	phase	phase	NOUN
fnp-3806	967	6	for	for	ADP
fnp-3806	967	7	aβ	aβ	NOUN
fnp-3806	967	8	plaques	plaque	NOUN
fnp-3806	967	9	“	"	PUNCT
fnp-3806	967	10	b	b	NOUN
fnp-3806	967	11	”	"	PUNCT
fnp-3806	967	12	braak	braak	NOUN
fnp-3806	967	13	and	and	CCONJ
fnp-3806	967	14	braak	braak	VERB
fnp-3806	967	15	nft	nft	PROPN
fnp-3806	967	16	stage	stage	PROPN
fnp-3806	967	17	“	"	PUNCT
fnp-3806	967	18	c	c	PROPN
fnp-3806	967	19	”	"	PUNCT
fnp-3806	967	20	cerad	cerad	ADJ
fnp-3806	967	21	neuritic	neuritic	ADJ
fnp-3806	967	22	plaque	plaque	NOUN
fnp-3806	967	23	score	score	NOUN
fnp-3806	967	24	0	0	NUM
fnp-3806	967	25	0	0	NUM
fnp-3806	967	26	0	0	NUM
fnp-3806	968	1	none	none	NOUN
fnp-3806	968	2	0	0	NUM
fnp-3806	969	1	none	none	NOUN
fnp-3806	969	2	1	1	NUM
fnp-3806	969	3	1	1	NUM
fnp-3806	969	4	or	or	CCONJ
fnp-3806	969	5	2	2	NUM
fnp-3806	969	6	1	1	NUM
fnp-3806	969	7	i	i	NOUN
fnp-3806	969	8	or	or	CCONJ
fnp-3806	969	9	ii	ii	NUM
fnp-3806	969	10	1	1	NUM
fnp-3806	969	11	sparse	sparse	ADJ
fnp-3806	969	12	2	2	NUM
fnp-3806	969	13	3	3	NUM
fnp-3806	969	14	2	2	NUM
fnp-3806	969	15	iii	iii	NUM
fnp-3806	969	16	or	or	CCONJ
fnp-3806	969	17	iv	iv	NUM
fnp-3806	969	18	2	2	NUM
fnp-3806	969	19	moderate	moderate	ADJ
fnp-3806	969	20	3	3	NUM
fnp-3806	969	21	4	4	NUM
fnp-3806	969	22	or	or	CCONJ
fnp-3806	969	23	5	5	NUM
fnp-3806	969	24	3	3	NUM
fnp-3806	969	25	v	v	NOUN
fnp-3806	969	26	or	or	CCONJ
fnp-3806	969	27	vi	vi	NOUN
fnp-3806	969	28	3	3	NUM
fnp-3806	969	29	frequent	frequent	ADJ
fnp-3806	969	30	table	table	NOUN
fnp-3806	969	31	1	1	NUM
fnp-3806	969	32	:	:	PUNCT
fnp-3806	969	33	“	"	PUNCT
fnp-3806	969	34	abc	abc	PROPN
fnp-3806	969	35	”	"	PUNCT
fnp-3806	969	36	score	score	NOUN
fnp-3806	969	37	for	for	ADP
fnp-3806	969	38	ad	ad	NOUN
fnp-3806	969	39	neuropathologic	neuropathologic	NOUN
fnp-3806	969	40	change	change	NOUN
fnp-3806	969	41	modified	modify	VERB
fnp-3806	969	42	from	from	ADP
fnp-3806	969	43	ref	ref	NOUN
fnp-3806	969	44	.	.	PUNCT
fnp-3806	970	1	49	49	NUM
fnp-3806	970	2	and	and	CCONJ
fnp-3806	970	3	50	50	NUM
fnp-3806	970	4	.	.	PUNCT
fnp-3806	971	1	national	national	PROPN
fnp-3806	971	2	institute	institute	PROPN
fnp-3806	971	3	on	on	ADP
fnp-3806	971	4	aging	age	VERB
fnp-3806	971	5	–	–	PUNCT
fnp-3806	971	6	alzheimer	alzheimer	PROPN
fnp-3806	971	7	’s	’s	NOUN
fnp-3806	971	8	association	association	PROPN
fnp-3806	971	9	(	(	PUNCT
fnp-3806	971	10	nia	nia	PROPN
fnp-3806	971	11	-	-	PUNCT
fnp-3806	971	12	aa	aa	ADJ
fnp-3806	971	13	)	)	PUNCT
fnp-3806	971	14	guidelines	guideline	NOUN
fnp-3806	971	15	for	for	ADP
fnp-3806	971	16	the	the	DET
fnp-3806	971	17	neuropathologic	neuropathologic	ADJ
fnp-3806	971	18	assessment	assessment	NOUN
fnp-3806	971	19	of	of	ADP
fnp-3806	971	20	alzheimer	alzheimer	PROPN
fnp-3806	971	21	’s	’s	PART
fnp-3806	971	22	disease	disease	NOUN
fnp-3806	971	23	.	.	PUNCT
fnp-3806	972	1	following	follow	VERB
fnp-3806	972	2	this	this	DET
fnp-3806	972	3	classification	classification	NOUN
fnp-3806	972	4	,	,	PUNCT
fnp-3806	972	5	the	the	DET
fnp-3806	972	6	score	score	NOUN
fnp-3806	972	7	levels	level	NOUN
fnp-3806	972	8	of	of	ADP
fnp-3806	972	9	ad	ad	NOUN
fnp-3806	972	10	neuropathologic	neuropathologic	NOUN
fnp-3806	972	11	change	change	NOUN
fnp-3806	972	12	are	be	AUX
fnp-3806	972	13	classified	classify	VERB
fnp-3806	972	14	as	as	ADP
fnp-3806	972	15	“	"	PUNCT
fnp-3806	972	16	not	not	PART
fnp-3806	972	17	”	"	PUNCT
fnp-3806	972	18	,	,	PUNCT
fnp-3806	972	19	“	"	PUNCT
fnp-3806	972	20	low	low	ADJ
fnp-3806	972	21	”	"	PUNCT
fnp-3806	972	22	,	,	PUNCT
fnp-3806	972	23	“	"	PUNCT
fnp-3806	972	24	intermediate	intermediate	ADJ
fnp-3806	972	25	”	"	PUNCT
fnp-3806	972	26	,	,	PUNCT
fnp-3806	972	27	and	and	CCONJ
fnp-3806	972	28	“	"	PUNCT
fnp-3806	972	29	high	high	ADJ
fnp-3806	972	30	”	"	PUNCT
fnp-3806	972	31	(	(	PUNCT
fnp-3806	972	32	table	table	NOUN
fnp-3806	972	33	2	2	NUM
fnp-3806	972	34	)	)	PUNCT
fnp-3806	972	35	.	.	PUNCT
fnp-3806	973	1	the	the	DET
fnp-3806	973	2	presence	presence	NOUN
fnp-3806	973	3	of	of	ADP
fnp-3806	973	4	aβ	aβ	PRON
fnp-3806	973	5	is	be	AUX
fnp-3806	973	6	mandatory	mandatory	ADJ
fnp-3806	973	7	.	.	PUNCT
fnp-3806	974	1	it	it	PRON
fnp-3806	974	2	is	be	AUX
fnp-3806	974	3	also	also	ADV
fnp-3806	974	4	stated	state	VERB
fnp-3806	974	5	that	that	SCONJ
fnp-3806	974	6	“	"	PUNCT
fnp-3806	974	7	medial	medial	ADJ
fnp-3806	974	8	temporal	temporal	ADJ
fnp-3806	974	9	lobe	lobe	ADJ
fnp-3806	974	10	nfts	nft	NOUN
fnp-3806	974	11	in	in	ADP
fnp-3806	974	12	the	the	DET
fnp-3806	974	13	absence	absence	NOUN
fnp-3806	974	14	of	of	ADP
fnp-3806	974	15	significant	significant	ADJ
fnp-3806	974	16	aβ	aβ	NOUN
fnp-3806	974	17	or	or	CCONJ
fnp-3806	974	18	neuritic	neuritic	ADJ
fnp-3806	974	19	plaques	plaque	NOUN
fnp-3806	974	20	occurs	occur	VERB
fnp-3806	974	21	in	in	ADP
fnp-3806	974	22	older	old	ADJ
fnp-3806	974	23	people	people	NOUN
fnp-3806	974	24	and	and	CCONJ
fnp-3806	974	25	may	may	AUX
fnp-3806	974	26	be	be	AUX
fnp-3806	974	27	seen	see	VERB
fnp-3806	974	28	in	in	ADP
fnp-3806	974	29	individuals	individual	NOUN
fnp-3806	974	30	without	without	ADP
fnp-3806	974	31	cognitive	cognitive	ADJ
fnp-3806	974	32	impairment	impairment	NOUN
fnp-3806	974	33	,	,	PUNCT
fnp-3806	974	34	with	with	ADP
fnp-3806	974	35	mild	mild	ADJ
fnp-3806	974	36	impairment	impairment	NOUN
fnp-3806	974	37	,	,	PUNCT
fnp-3806	974	38	or	or	CCONJ
fnp-3806	974	39	with	with	ADP
fnp-3806	974	40	cognitive	cognitive	ADJ
fnp-3806	974	41	impairment	impairment	NOUN
fnp-3806	974	42	from	from	ADP
fnp-3806	974	43	causes	cause	NOUN
fnp-3806	974	44	other	other	ADJ
fnp-3806	974	45	than	than	ADP
fnp-3806	974	46	ad	ad	NOUN
fnp-3806	974	47	”	"	PUNCT
fnp-3806	974	48	(	(	PUNCT
fnp-3806	974	49	49	49	NUM
fnp-3806	974	50	,	,	PUNCT
fnp-3806	974	51	50	50	NUM
fnp-3806	974	52	)	)	PUNCT
fnp-3806	974	53	.	.	PUNCT
fnp-3806	975	1	to	to	PART
fnp-3806	975	2	support	support	VERB
fnp-3806	975	3	this	this	DET
fnp-3806	975	4	assertion	assertion	NOUN
fnp-3806	975	5	,	,	PUNCT
fnp-3806	975	6	a	a	DET
fnp-3806	975	7	previous	previous	ADJ
fnp-3806	975	8	work	work	NOUN
fnp-3806	975	9	is	be	AUX
fnp-3806	975	10	cited	cite	VERB
fnp-3806	975	11	:	:	PUNCT
fnp-3806	975	12	“	"	PUNCT
fnp-3806	975	13	brains	brain	NOUN
fnp-3806	975	14	that	that	PRON
fnp-3806	975	15	have	have	VERB
fnp-3806	975	16	many	many	ADJ
fnp-3806	975	17	nfts	nft	NOUN
fnp-3806	975	18	in	in	ADP
fnp-3806	975	19	medial	medial	ADJ
fnp-3806	975	20	temporal	temporal	ADJ
fnp-3806	975	21	lobe	lobe	NOUN
fnp-3806	975	22	structures	structure	NOUN
fnp-3806	975	23	(	(	PUNCT
fnp-3806	975	24	braak	braak	PROPN
fnp-3806	975	25	stage	stage	PROPN
fnp-3806	975	26	iii	iii	PROPN
fnp-3806	975	27	or	or	CCONJ
fnp-3806	975	28	iv	iv	NUM
fnp-3806	975	29	)	)	PUNCT
fnp-3806	975	30	but	but	CCONJ
fnp-3806	975	31	no	no	DET
fnp-3806	975	32	cortical	cortical	ADJ
fnp-3806	975	33	sps	sps	NOUN
fnp-3806	975	34	may	may	AUX
fnp-3806	975	35	be	be	AUX
fnp-3806	975	36	a	a	DET
fnp-3806	975	37	diagnostic	diagnostic	ADJ
fnp-3806	975	38	dilemma	dilemma	NOUN
fnp-3806	975	39	;	;	PUNCT
fnp-3806	975	40	they	they	PRON
fnp-3806	975	41	also	also	ADV
fnp-3806	975	42	raise	raise	VERB
fnp-3806	975	43	questions	question	NOUN
fnp-3806	975	44	about	about	ADP
fnp-3806	975	45	the	the	DET
fnp-3806	975	46	amyloid	amyloid	NOUN
fnp-3806	975	47	cascade	cascade	NOUN
fnp-3806	975	48	hypothesis	hypothesis	NOUN
fnp-3806	975	49	of	of	ADP
fnp-3806	975	50	ad	ad	NOUN
fnp-3806	975	51	in	in	ADP
fnp-3806	975	52	which	which	PRON
fnp-3806	975	53	nft	nft	PROPN
fnp-3806	975	54	development	development	PROPN
fnp-3806	975	55	is	be	AUX
fnp-3806	975	56	thought	think	VERB
fnp-3806	975	57	to	to	PART
fnp-3806	975	58	occur	occur	VERB
fnp-3806	975	59	downstream	downstream	ADV
fnp-3806	975	60	of	of	ADP
fnp-3806	975	61	the	the	DET
fnp-3806	975	62	development	development	NOUN
fnp-3806	975	63	of	of	ADP
fnp-3806	975	64	amyloid	amyloid	NOUN
fnp-3806	975	65	plaques	plaque	NOUN
fnp-3806	975	66	”	"	PUNCT
fnp-3806	975	67	(	(	PUNCT
fnp-3806	975	68	1279	1279	NUM
fnp-3806	975	69	)	)	PUNCT
fnp-3806	975	70	.	.	PUNCT
fnp-3806	976	1	more	more	ADV
fnp-3806	976	2	recently	recently	ADV
fnp-3806	976	3	,	,	PUNCT
fnp-3806	976	4	the	the	DET
fnp-3806	976	5	introduction	introduction	NOUN
fnp-3806	976	6	of	of	ADP
fnp-3806	976	7	the	the	DET
fnp-3806	976	8	term	term	NOUN
fnp-3806	976	9	part	part	NOUN
fnp-3806	976	10	has	have	AUX
fnp-3806	976	11	been	be	AUX
fnp-3806	976	12	used	use	VERB
fnp-3806	976	13	to	to	PART
fnp-3806	976	14	name	name	VERB
fnp-3806	976	15	cases	case	NOUN
fnp-3806	976	16	with	with	ADP
fnp-3806	976	17	nft	nft	PROPN
fnp-3806	976	18	pathology	pathology	PROPN
fnp-3806	976	19	without	without	ADP
fnp-3806	976	20	sps	sps	PROPN
fnp-3806	976	21	(	(	PUNCT
fnp-3806	976	22	see	see	VERB
fnp-3806	976	23	section	section	NOUN
fnp-3806	976	24	21a	21a	NUM
fnp-3806	976	25	)	)	PUNCT
fnp-3806	976	26	.	.	PUNCT
fnp-3806	977	1	ad	ad	NOUN
fnp-3806	977	2	neuropathologic	neuropathologic	PROPN
fnp-3806	977	3	change	change	NOUN
fnp-3806	977	4	b	b	PROPN
fnp-3806	977	5	a	a	DET
fnp-3806	977	6	c	c	NOUN
fnp-3806	977	7	0	0	NUM
fnp-3806	977	8	or	or	CCONJ
fnp-3806	977	9	1	1	NUM
fnp-3806	977	10	2	2	NUM
fnp-3806	977	11	3	3	NUM
fnp-3806	977	12	0	0	NUM
fnp-3806	977	13	0	0	NUM
fnp-3806	977	14	not	not	PART
fnp-3806	977	15	not	not	PART
fnp-3806	977	16	not	not	PART
fnp-3806	977	17	1	1	NUM
fnp-3806	977	18	0	0	NUM
fnp-3806	977	19	or	or	CCONJ
fnp-3806	977	20	1	1	NUM
fnp-3806	977	21	low	low	ADJ
fnp-3806	977	22	low	low	ADJ
fnp-3806	977	23	low	low	ADJ
fnp-3806	977	24	2	2	NUM
fnp-3806	977	25	or	or	CCONJ
fnp-3806	977	26	3	3	NUM
fnp-3806	977	27	low	low	ADJ
fnp-3806	977	28	intermediate	intermediate	ADJ
fnp-3806	977	29	intermediate	intermediate	ADJ
fnp-3806	977	30	2	2	NUM
fnp-3806	977	31	any	any	PRON
fnp-3806	977	32	c	c	NOUN
fnp-3806	977	33	low	low	ADJ
fnp-3806	977	34	intermediate	intermediate	ADJ
fnp-3806	977	35	intermediate	intermediate	ADJ
fnp-3806	977	36	3	3	NUM
fnp-3806	977	37	0	0	NUM
fnp-3806	977	38	or	or	CCONJ
fnp-3806	977	39	1	1	NUM
fnp-3806	977	40	low	low	ADJ
fnp-3806	977	41	intermediate	intermediate	ADJ
fnp-3806	977	42	intermediate	intermediate	ADJ
fnp-3806	977	43	2	2	NUM
fnp-3806	977	44	or	or	CCONJ
fnp-3806	977	45	3	3	NUM
fnp-3806	977	46	low	low	ADJ
fnp-3806	977	47	intermediate	intermediate	ADJ
fnp-3806	977	48	high	high	ADJ
fnp-3806	977	49	table	table	NOUN
fnp-3806	977	50	2	2	NUM
fnp-3806	977	51	:	:	PUNCT
fnp-3806	977	52	“	"	PUNCT
fnp-3806	977	53	abc	abc	PROPN
fnp-3806	977	54	”	"	PUNCT
fnp-3806	977	55	score	score	NOUN
fnp-3806	977	56	level	level	NOUN
fnp-3806	977	57	of	of	ADP
fnp-3806	977	58	ad	ad	NOUN
fnp-3806	977	59	neuropathologic	neuropathologic	NOUN
fnp-3806	977	60	change	change	NOUN
fnp-3806	977	61	.	.	PUNCT
fnp-3806	978	1	aβ	aβ	X
fnp-3806	978	2	/	/	SYM
fnp-3806	978	3	amyloid	amyloid	NOUN
fnp-3806	978	4	plaques	plaque	NOUN
fnp-3806	978	5	(	(	PUNCT
fnp-3806	978	6	a	a	X
fnp-3806	978	7	)	)	PUNCT
fnp-3806	978	8	,	,	PUNCT
fnp-3806	978	9	nft	nft	PROPN
fnp-3806	978	10	stage	stage	NOUN
fnp-3806	978	11	(	(	PUNCT
fnp-3806	978	12	b	b	NOUN
fnp-3806	978	13	)	)	PUNCT
fnp-3806	978	14	,	,	PUNCT
fnp-3806	978	15	and	and	CCONJ
fnp-3806	978	16	neuritic	neuritic	ADJ
fnp-3806	978	17	plaque	plaque	NOUN
fnp-3806	978	18	score	score	NOUN
fnp-3806	978	19	(	(	PUNCT
fnp-3806	978	20	c	c	NOUN
fnp-3806	978	21	)	)	PUNCT
fnp-3806	978	22	.	.	PUNCT
fnp-3806	979	1	the	the	DET
fnp-3806	979	2	combination	combination	NOUN
fnp-3806	979	3	of	of	ADP
fnp-3806	979	4	a	a	DET
fnp-3806	979	5	,	,	PUNCT
fnp-3806	979	6	b	b	NOUN
fnp-3806	979	7	,	,	PUNCT
fnp-3806	979	8	and	and	CCONJ
fnp-3806	979	9	c	c	NOUN
fnp-3806	979	10	scores	score	NOUN
fnp-3806	979	11	is	be	AUX
fnp-3806	979	12	designated	designate	VERB
fnp-3806	979	13	as	as	ADP
fnp-3806	979	14	“	"	PUNCT
fnp-3806	979	15	not	not	PART
fnp-3806	979	16	”	"	PUNCT
fnp-3806	979	17	,	,	PUNCT
fnp-3806	979	18	“	"	PUNCT
fnp-3806	979	19	low	low	ADJ
fnp-3806	979	20	”	"	PUNCT
fnp-3806	979	21	,	,	PUNCT
fnp-3806	979	22	“	"	PUNCT
fnp-3806	979	23	intermediate	intermediate	ADJ
fnp-3806	979	24	”	"	PUNCT
fnp-3806	979	25	or	or	CCONJ
fnp-3806	979	26	“	"	PUNCT
fnp-3806	979	27	high	high	ADJ
fnp-3806	979	28	”	"	PUNCT
fnp-3806	979	29	ad	ad	NOUN
fnp-3806	979	30	neuropathologic	neuropathologic	NOUN
fnp-3806	979	31	change	change	NOUN
fnp-3806	979	32	.	.	PUNCT
fnp-3806	980	1	“	"	PUNCT
fnp-3806	980	2	intermediate	intermediate	ADJ
fnp-3806	980	3	”	"	PUNCT
fnp-3806	980	4	or	or	CCONJ
fnp-3806	980	5	“	"	PUNCT
fnp-3806	980	6	high	high	ADJ
fnp-3806	980	7	”	"	PUNCT
fnp-3806	980	8	ad	ad	NOUN
fnp-3806	980	9	neuropathologic	neuropathologic	NOUN
fnp-3806	980	10	change	change	NOUN
fnp-3806	980	11	is	be	AUX
fnp-3806	980	12	considered	consider	VERB
fnp-3806	980	13	sufficient	sufficient	ADJ
fnp-3806	980	14	for	for	ADP
fnp-3806	980	15	dementia	dementia	NOUN
fnp-3806	980	16	.	.	PUNCT
fnp-3806	981	1	national	national	PROPN
fnp-3806	981	2	institute	institute	PROPN
fnp-3806	981	3	on	on	ADP
fnp-3806	981	4	aging	age	VERB
fnp-3806	981	5	–	–	PUNCT
fnp-3806	981	6	alzheimer	alzheimer	PROPN
fnp-3806	981	7	’s	’s	NOUN
fnp-3806	981	8	association	association	PROPN
fnp-3806	981	9	(	(	PUNCT
fnp-3806	981	10	nia	nia	PROPN
fnp-3806	981	11	-	-	PUNCT
fnp-3806	981	12	aa	aa	ADJ
fnp-3806	981	13	)	)	PUNCT
fnp-3806	981	14	guidelines	guideline	NOUN
fnp-3806	981	15	for	for	ADP
fnp-3806	981	16	the	the	DET
fnp-3806	981	17	neuropathologic	neuropathologic	ADJ
fnp-3806	981	18	assessment	assessment	NOUN
fnp-3806	981	19	of	of	ADP
fnp-3806	981	20	alzheimer	alzheimer	PROPN
fnp-3806	981	21	’s	’s	PART
fnp-3806	981	22	disease	disease	NOUN
fnp-3806	981	23	.	.	PUNCT
fnp-3806	982	1	a	a	DET
fnp-3806	982	2	key	key	ADJ
fnp-3806	982	3	point	point	NOUN
fnp-3806	982	4	of	of	ADP
fnp-3806	982	5	this	this	DET
fnp-3806	982	6	neuropathologic	neuropathologic	ADJ
fnp-3806	982	7	classification	classification	NOUN
fnp-3806	982	8	is	be	AUX
fnp-3806	982	9	the	the	DET
fnp-3806	982	10	notion	notion	NOUN
fnp-3806	982	11	that	that	SCONJ
fnp-3806	982	12	β	β	X
fnp-3806	982	13	-	-	NOUN
fnp-3806	982	14	amyloid	amyloid	ADJ
fnp-3806	982	15	deposition	deposition	NOUN
fnp-3806	982	16	is	be	AUX
fnp-3806	982	17	the	the	DET
fnp-3806	982	18	first	first	ADJ
fnp-3806	982	19	“	"	PUNCT
fnp-3806	982	20	sine	sine	ADJ
fnp-3806	982	21	-	-	PUNCT
fnp-3806	982	22	qua	qua	NOUN
fnp-3806	982	23	-	-	PUNCT
fnp-3806	982	24	non	non	ADJ
fnp-3806	982	25	”	"	PUNCT
fnp-3806	982	26	condition	condition	NOUN
fnp-3806	982	27	to	to	PART
fnp-3806	982	28	consider	consider	VERB
fnp-3806	982	29	the	the	DET
fnp-3806	982	30	possibility	possibility	NOUN
fnp-3806	982	31	of	of	ADP
fnp-3806	982	32	ad	ad	NOUN
fnp-3806	982	33	.	.	PUNCT
fnp-3806	983	1	the	the	DET
fnp-3806	983	2	occurrence	occurrence	NOUN
fnp-3806	983	3	of	of	ADP
fnp-3806	983	4	nfts	nft	NOUN
fnp-3806	983	5	without	without	ADP
fnp-3806	983	6	β	β	NOUN
fnp-3806	983	7	-	-	NOUN
fnp-3806	983	8	amyloid	amyloid	ADJ
fnp-3806	983	9	plaques	plaque	NOUN
fnp-3806	983	10	is	be	AUX
fnp-3806	983	11	not	not	PART
fnp-3806	983	12	consistent	consistent	ADJ
fnp-3806	983	13	with	with	ADP
fnp-3806	983	14	ad	ad	NOUN
fnp-3806	983	15	at	at	ADP
fnp-3806	983	16	any	any	DET
fnp-3806	983	17	stage	stage	NOUN
fnp-3806	983	18	.	.	PUNCT
fnp-3806	984	1	the	the	DET
fnp-3806	984	2	neuropathological	neuropathological	ADJ
fnp-3806	984	3	proposal	proposal	NOUN
fnp-3806	984	4	of	of	ADP
fnp-3806	984	5	the	the	DET
fnp-3806	984	6	national	national	PROPN
fnp-3806	984	7	institute	institute	PROPN
fnp-3806	984	8	on	on	ADP
fnp-3806	984	9	aging	age	VERB
fnp-3806	984	10	-	-	PUNCT
fnp-3806	984	11	alzheimer	alzheimer	NOUN
fnp-3806	984	12	’s	’s	PART
fnp-3806	984	13	association	association	NOUN
fnp-3806	984	14	assumes	assume	VERB
fnp-3806	984	15	the	the	DET
fnp-3806	984	16	“	"	PUNCT
fnp-3806	984	17	amyloid	amyloid	NOUN
fnp-3806	984	18	cascade	cascade	NOUN
fnp-3806	984	19	hypothesis	hypothesis	NOUN
fnp-3806	984	20	”	"	PUNCT
fnp-3806	984	21	as	as	ADP
fnp-3806	984	22	the	the	DET
fnp-3806	984	23	cause	cause	NOUN
fnp-3806	984	24	of	of	ADP
fnp-3806	984	25	sad	sad	ADJ
fnp-3806	984	26	.	.	PUNCT
fnp-3806	985	1	yet	yet	CCONJ
fnp-3806	985	2	the	the	DET
fnp-3806	985	3	cognitive	cognitive	ADJ
fnp-3806	985	4	status	status	NOUN
fnp-3806	985	5	correlates	correlate	VERB
fnp-3806	985	6	with	with	ADP
fnp-3806	985	7	nft	nft	PROPN
fnp-3806	985	8	burden	burden	NOUN
fnp-3806	985	9	rather	rather	ADV
fnp-3806	985	10	than	than	ADP
fnp-3806	985	11	with	with	ADP
fnp-3806	985	12	β	β	NOUN
fnp-3806	985	13	-	-	ADJ
fnp-3806	985	14	amyloid	amyloid	ADJ
fnp-3806	985	15	plaques	plaque	NOUN
fnp-3806	985	16	(	(	PUNCT
fnp-3806	985	17	331	331	NUM
fnp-3806	985	18	)	)	PUNCT
fnp-3806	985	19	.	.	PUNCT
fnp-3806	986	1	21	21	NUM
fnp-3806	986	2	.	.	PUNCT
fnp-3806	986	3	primary	primary	ADJ
fnp-3806	986	4	age	age	NOUN
fnp-3806	986	5	-	-	PUNCT
fnp-3806	986	6	related	relate	VERB
fnp-3806	986	7	tauopathy	tauopathy	NOUN
fnp-3806	986	8	(	(	PUNCT
fnp-3806	986	9	part	part	NOUN
fnp-3806	986	10	)	)	PUNCT
fnp-3806	986	11	,	,	PUNCT
fnp-3806	986	12	rapidly	rapidly	ADV
fnp-3806	986	13	progressive	progressive	ADJ
fnp-3806	986	14	sad	sad	ADJ
fnp-3806	986	15	,	,	PUNCT
fnp-3806	986	16	and	and	CCONJ
fnp-3806	986	17	sad	sad	ADJ
fnp-3806	986	18	resilience	resilience	NOUN
fnp-3806	986	19	21a	21a	NUM
fnp-3806	986	20	.	.	PUNCT
fnp-3806	987	1	part	part	NOUN
fnp-3806	987	2	in	in	ADP
fnp-3806	987	3	2014	2014	NUM
fnp-3806	987	4	,	,	PUNCT
fnp-3806	987	5	the	the	DET
fnp-3806	987	6	term	term	NOUN
fnp-3806	987	7	part	part	NOUN
fnp-3806	987	8	,	,	PUNCT
fnp-3806	987	9	a	a	DET
fnp-3806	987	10	common	common	ADJ
fnp-3806	987	11	pathology	pathology	NOUN
fnp-3806	987	12	associated	associate	VERB
fnp-3806	987	13	with	with	ADP
fnp-3806	987	14	human	human	ADJ
fnp-3806	987	15	aging	aging	NOUN
fnp-3806	987	16	,	,	PUNCT
fnp-3806	987	17	was	be	AUX
fnp-3806	987	18	proposed	propose	VERB
fnp-3806	987	19	to	to	PART
fnp-3806	987	20	categorize	categorize	VERB
fnp-3806	987	21	a	a	DET
fnp-3806	987	22	subpopulation	subpopulation	NOUN
fnp-3806	987	23	of	of	ADP
fnp-3806	987	24	individuals	individual	NOUN
fnp-3806	987	25	with	with	ADP
fnp-3806	987	26	normal	normal	ADJ
fnp-3806	987	27	cognition	cognition	NOUN
fnp-3806	987	28	or	or	CCONJ
fnp-3806	987	29	with	with	ADP
fnp-3806	987	30	mci	mci	PROPN
fnp-3806	987	31	showing	show	VERB
fnp-3806	987	32	nft	nft	PROPN
fnp-3806	987	33	pathology	pathology	NOUN
fnp-3806	987	34	at	at	ADP
fnp-3806	987	35	stages	stage	NOUN
fnp-3806	987	36	i	i	NOUN
fnp-3806	987	37	-	-	PUNCT
fnp-3806	987	38	iv	iv	NOUN
fnp-3806	987	39	of	of	ADP
fnp-3806	987	40	braak	braak	NOUN
fnp-3806	987	41	and	and	CCONJ
fnp-3806	987	42	no	no	DET
fnp-3806	987	43	sps	sps	NOUN
fnp-3806	987	44	,	,	PUNCT
fnp-3806	987	45	and	and	CCONJ
fnp-3806	987	46	slower	slow	ADJ
fnp-3806	987	47	progression	progression	NOUN
fnp-3806	987	48	to	to	ADP
fnp-3806	987	49	the	the	DET
fnp-3806	987	50	clinical	clinical	ADJ
fnp-3806	987	51	stage	stage	NOUN
fnp-3806	987	52	of	of	ADP
fnp-3806	987	53	dementia	dementia	NOUN
fnp-3806	987	54	in	in	ADP
fnp-3806	987	55	some	some	DET
fnp-3806	987	56	individuals	individual	NOUN
fnp-3806	987	57	(	(	PUNCT
fnp-3806	987	58	1280	1280	NUM
fnp-3806	987	59	-	-	SYM
fnp-3806	987	60	1283	1283	NUM
fnp-3806	987	61	)	)	PUNCT
fnp-3806	987	62	.	.	PUNCT
fnp-3806	988	1	the	the	DET
fnp-3806	988	2	concept	concept	NOUN
fnp-3806	988	3	of	of	ADP
fnp-3806	988	4	part	part	NOUN
fnp-3806	988	5	derives	derive	VERB
fnp-3806	988	6	from	from	ADP
fnp-3806	988	7	the	the	DET
fnp-3806	988	8	interpretation	interpretation	NOUN
fnp-3806	988	9	of	of	ADP
fnp-3806	988	10	the	the	DET
fnp-3806	988	11	“	"	PUNCT
fnp-3806	988	12	β	β	NOUN
fnp-3806	988	13	-	-	ADJ
fnp-3806	988	14	amyloid	amyloid	ADJ
fnp-3806	988	15	cascade	cascade	NOUN
fnp-3806	988	16	hypothesis	hypothesis	NOUN
fnp-3806	988	17	”	"	PUNCT
fnp-3806	988	18	as	as	ADP
fnp-3806	988	19	the	the	DET
fnp-3806	988	20	cause	cause	NOUN
fnp-3806	988	21	of	of	ADP
fnp-3806	988	22	ad	ad	NOUN
fnp-3806	988	23	.	.	PUNCT
fnp-3806	989	1	in	in	ADP
fnp-3806	989	2	other	other	ADJ
fnp-3806	989	3	words	word	NOUN
fnp-3806	989	4	,	,	PUNCT
fnp-3806	989	5	it	it	PRON
fnp-3806	989	6	is	be	AUX
fnp-3806	989	7	assumed	assume	VERB
fnp-3806	989	8	that	that	SCONJ
fnp-3806	989	9	the	the	DET
fnp-3806	989	10	presence	presence	NOUN
fnp-3806	989	11	of	of	ADP
fnp-3806	989	12	nfts	nft	NOUN
fnp-3806	989	13	without	without	ADP
fnp-3806	989	14	aβ	aβ	NOUN
fnp-3806	989	15	deposition	deposition	NOUN
fnp-3806	989	16	is	be	AUX
fnp-3806	989	17	not	not	PART
fnp-3806	989	18	ad	ad	NOUN
fnp-3806	989	19	and	and	CCONJ
fnp-3806	989	20	therefore	therefore	ADV
fnp-3806	989	21	,	,	PUNCT
fnp-3806	989	22	cases	case	NOUN
fnp-3806	989	23	with	with	ADP
fnp-3806	989	24	nfts	nft	NOUN
fnp-3806	989	25	and	and	CCONJ
fnp-3806	989	26	without	without	ADP
fnp-3806	989	27	sps	sps	PROPN
fnp-3806	989	28	do	do	AUX
fnp-3806	989	29	not	not	PART
fnp-3806	989	30	match	match	VERB
fnp-3806	989	31	with	with	ADP
fnp-3806	989	32	the	the	DET
fnp-3806	989	33	neuropathologic	neuropathologic	ADJ
fnp-3806	989	34	assessment	assessment	NOUN
fnp-3806	989	35	of	of	ADP
fnp-3806	989	36	ad	ad	NOUN
fnp-3806	989	37	proposed	propose	VERB
fnp-3806	989	38	by	by	ADP
fnp-3806	989	39	the	the	DET
fnp-3806	989	40	nia	nia	PROPN
fnp-3806	989	41	-	-	PUNCT
fnp-3806	989	42	aa	aa	PROPN
fnp-3806	989	43	.	.	PUNCT
fnp-3806	990	1	part	part	NOUN
fnp-3806	990	2	includes	include	VERB
fnp-3806	990	3	the	the	DET
fnp-3806	990	4	majority	majority	NOUN
fnp-3806	990	5	of	of	ADP
fnp-3806	990	6	individuals	individual	NOUN
fnp-3806	990	7	aged	age	VERB
fnp-3806	990	8	65	65	NUM
fnp-3806	990	9	or	or	CCONJ
fnp-3806	990	10	older	old	ADJ
fnp-3806	990	11	with	with	ADP
fnp-3806	990	12	first	first	ADJ
fnp-3806	990	13	stages	stage	NOUN
fnp-3806	990	14	of	of	ADP
fnp-3806	990	15	nft	nft	PROPN
fnp-3806	990	16	pathology	pathology	PROPN
fnp-3806	990	17	and	and	CCONJ
fnp-3806	990	18	without	without	ADP
fnp-3806	990	19	sps	sps	PROPN
fnp-3806	990	20	.	.	PUNCT
fnp-3806	991	1	the	the	DET
fnp-3806	991	2	individuals	individual	NOUN
fnp-3806	991	3	represent	represent	VERB
fnp-3806	991	4	about	about	ADV
fnp-3806	991	5	85	85	NUM
fnp-3806	991	6	%	%	NOUN
fnp-3806	991	7	of	of	ADP
fnp-3806	991	8	human	human	ADJ
fnp-3806	991	9	beings	being	NOUN
fnp-3806	991	10	at	at	ADP
fnp-3806	991	11	the	the	DET
fnp-3806	991	12	age	age	NOUN
fnp-3806	991	13	of	of	ADP
fnp-3806	991	14	65	65	NUM
fnp-3806	991	15	(	(	PUNCT
fnp-3806	991	16	328	328	NUM
fnp-3806	991	17	,	,	PUNCT
fnp-3806	991	18	329	329	NUM
fnp-3806	991	19	,	,	PUNCT
fnp-3806	991	20	1284	1284	NUM
fnp-3806	991	21	)	)	PUNCT
fnp-3806	991	22	,	,	PUNCT
fnp-3806	991	23	and	and	CCONJ
fnp-3806	991	24	are	be	AUX
fnp-3806	991	25	considered	consider	VERB
fnp-3806	991	26	clinically	clinically	ADV
fnp-3806	991	27	affected	affect	VERB
fnp-3806	991	28	by	by	ADP
fnp-3806	991	29	“	"	PUNCT
fnp-3806	991	30	normal	normal	ADJ
fnp-3806	991	31	brain	brain	NOUN
fnp-3806	991	32	aging	aging	NOUN
fnp-3806	991	33	”	"	PUNCT
fnp-3806	991	34	.	.	PUNCT
fnp-3806	992	1	therefore	therefore	ADV
fnp-3806	992	2	,	,	PUNCT
fnp-3806	992	3	part	part	NOUN
fnp-3806	992	4	appears	appear	VERB
fnp-3806	992	5	to	to	PART
fnp-3806	992	6	be	be	AUX
fnp-3806	992	7	a	a	DET
fnp-3806	992	8	predominant	predominant	ADJ
fnp-3806	992	9	disorder	disorder	NOUN
fnp-3806	992	10	until	until	ADP
fnp-3806	992	11	the	the	DET
fnp-3806	992	12	emergence	emergence	NOUN
fnp-3806	992	13	of	of	ADP
fnp-3806	992	14	sps	sps	PROPN
fnp-3806	992	15	(	(	PUNCT
fnp-3806	992	16	41	41	NUM
fnp-3806	992	17	,	,	PUNCT
fnp-3806	992	18	329	329	NUM
fnp-3806	992	19	,	,	PUNCT
fnp-3806	992	20	336	336	NUM
fnp-3806	992	21	,	,	PUNCT
fnp-3806	992	22	1284	1284	NUM
fnp-3806	992	23	)	)	PUNCT
fnp-3806	992	24	.	.	PUNCT
fnp-3806	993	1	once	once	ADV
fnp-3806	993	2	a	a	DET
fnp-3806	993	3	substantial	substantial	ADJ
fnp-3806	993	4	number	number	NOUN
fnp-3806	993	5	of	of	ADP
fnp-3806	993	6	sps	sps	PROPN
fnp-3806	993	7	appears	appear	VERB
fnp-3806	993	8	in	in	ADP
fnp-3806	993	9	the	the	DET
fnp-3806	993	10	brain	brain	NOUN
fnp-3806	993	11	,	,	PUNCT
fnp-3806	993	12	ad	ad	NOUN
fnp-3806	993	13	is	be	AUX
fnp-3806	993	14	overriding	override	VERB
fnp-3806	993	15	,	,	PUNCT
fnp-3806	993	16	whereas	whereas	SCONJ
fnp-3806	993	17	dementia	dementia	NOUN
fnp-3806	993	18	with	with	ADP
fnp-3806	993	19	only	only	ADJ
fnp-3806	993	20	tangles	tangle	NOUN
fnp-3806	993	21	(	(	PUNCT
fnp-3806	993	22	or	or	CCONJ
fnp-3806	993	23	tangle	tangle	NOUN
fnp-3806	993	24	-	-	PUNCT
fnp-3806	993	25	predominant	predominant	ADJ
fnp-3806	993	26	dementia	dementia	NOUN
fnp-3806	993	27	)	)	PUNCT
fnp-3806	993	28	which	which	PRON
fnp-3806	993	29	would	would	AUX
fnp-3806	993	30	be	be	AUX
fnp-3806	993	31	the	the	DET
fnp-3806	993	32	logical	logical	ADJ
fnp-3806	993	33	progression	progression	NOUN
fnp-3806	993	34	of	of	ADP
fnp-3806	993	35	part	part	NOUN
fnp-3806	993	36	decays	decay	NOUN
fnp-3806	993	37	and	and	CCONJ
fnp-3806	993	38	becomes	become	VERB
fnp-3806	993	39	rare	rare	ADJ
fnp-3806	993	40	(	(	PUNCT
fnp-3806	993	41	1285	1285	NUM
fnp-3806	993	42	)	)	PUNCT
fnp-3806	993	43	.	.	PUNCT
fnp-3806	994	1	it	it	PRON
fnp-3806	994	2	has	have	AUX
fnp-3806	994	3	been	be	AUX
fnp-3806	994	4	stated	state	VERB
fnp-3806	994	5	that	that	SCONJ
fnp-3806	994	6	the	the	DET
fnp-3806	994	7	frequency	frequency	NOUN
fnp-3806	994	8	of	of	ADP
fnp-3806	994	9	part	part	NOUN
fnp-3806	994	10	increases	increase	NOUN
fnp-3806	994	11	at	at	ADP
fnp-3806	994	12	the	the	DET
fnp-3806	994	13	age	age	NOUN
fnp-3806	994	14	of	of	ADP
fnp-3806	994	15	85	85	NUM
fnp-3806	994	16	years	year	NOUN
fnp-3806	994	17	(	(	PUNCT
fnp-3806	994	18	1286	1286	NUM
fnp-3806	994	19	)	)	PUNCT
fnp-3806	994	20	.	.	PUNCT
fnp-3806	995	1	however	however	ADV
fnp-3806	995	2	,	,	PUNCT
fnp-3806	995	3	most	most	ADJ
fnp-3806	995	4	individuals	individual	NOUN
fnp-3806	995	5	with	with	ADP
fnp-3806	995	6	nft	nft	PROPN
fnp-3806	995	7	pathology	pathology	PROPN
fnp-3806	995	8	at	at	ADP
fnp-3806	995	9	stages	stage	NOUN
fnp-3806	995	10	i	i	PROPN
fnp-3806	995	11	-	-	PUNCT
fnp-3806	995	12	iii	iii	PROPN
fnp-3806	995	13	without	without	ADP
fnp-3806	995	14	sps	sps	NOUN
fnp-3806	995	15	are	be	AUX
fnp-3806	995	16	younger	young	ADJ
fnp-3806	995	17	in	in	ADP
fnp-3806	995	18	largest	large	ADJ
fnp-3806	995	19	series	series	NOUN
fnp-3806	995	20	of	of	ADP
fnp-3806	995	21	cases	case	NOUN
fnp-3806	995	22	(	(	PUNCT
fnp-3806	995	23	41	41	NUM
fnp-3806	995	24	,	,	PUNCT
fnp-3806	995	25	329	329	NUM
fnp-3806	995	26	,	,	PUNCT
fnp-3806	995	27	1284	1284	NUM
fnp-3806	995	28	)	)	PUNCT
fnp-3806	995	29	.	.	PUNCT
fnp-3806	996	1	the	the	DET
fnp-3806	996	2	distribution	distribution	NOUN
fnp-3806	996	3	of	of	ADP
fnp-3806	996	4	tau	tau	PROPN
fnp-3806	996	5	pathology	pathology	NOUN
fnp-3806	996	6	in	in	ADP
fnp-3806	996	7	ca1	ca1	PROPN
fnp-3806	996	8	and	and	CCONJ
fnp-3806	996	9	ca3	ca3	NOUN
fnp-3806	996	10	regions	region	NOUN
fnp-3806	996	11	of	of	ADP
fnp-3806	996	12	the	the	DET
fnp-3806	996	13	hippocampus	hippocampus	NOUN
fnp-3806	996	14	is	be	AUX
fnp-3806	996	15	reported	report	VERB
fnp-3806	996	16	to	to	PART
fnp-3806	996	17	be	be	AUX
fnp-3806	996	18	different	different	ADJ
fnp-3806	996	19	in	in	ADP
fnp-3806	996	20	part	part	NOUN
fnp-3806	996	21	and	and	CCONJ
fnp-3806	996	22	sad	sad	ADJ
fnp-3806	996	23	.	.	PUNCT
fnp-3806	997	1	however	however	ADV
fnp-3806	997	2	,	,	PUNCT
fnp-3806	997	3	in	in	ADP
fnp-3806	997	4	one	one	NUM
fnp-3806	997	5	series	series	NOUN
fnp-3806	997	6	,	,	PUNCT
fnp-3806	997	7	the	the	DET
fnp-3806	997	8	mean	mean	ADJ
fnp-3806	997	9	age	age	NOUN
fnp-3806	997	10	of	of	ADP
fnp-3806	997	11	the	the	DET
fnp-3806	997	12	individuals	individual	NOUN
fnp-3806	997	13	was	be	AUX
fnp-3806	997	14	about	about	ADV
fnp-3806	997	15	88	88	NUM
fnp-3806	997	16	but	but	CCONJ
fnp-3806	997	17	the	the	DET
fnp-3806	997	18	nft	nft	PROPN
fnp-3806	997	19	stages	stage	NOUN
fnp-3806	997	20	varied	varied	ADJ
fnp-3806	997	21	in	in	ADP
fnp-3806	997	22	the	the	DET
fnp-3806	997	23	samples	sample	NOUN
fnp-3806	997	24	with	with	ADP
fnp-3806	997	25	part	part	NOUN
fnp-3806	997	26	and	and	CCONJ
fnp-3806	997	27	sad	sad	ADJ
fnp-3806	997	28	(	(	PUNCT
fnp-3806	997	29	1287	1287	NUM
fnp-3806	997	30	)	)	PUNCT
fnp-3806	997	31	.	.	PUNCT
fnp-3806	998	1	in	in	ADP
fnp-3806	998	2	another	another	DET
fnp-3806	998	3	series	series	NOUN
fnp-3806	998	4	(	(	PUNCT
fnp-3806	998	5	mean	mean	VERB
fnp-3806	998	6	age	age	NOUN
fnp-3806	998	7	84.3	84.3	NUM
fnp-3806	998	8	±	±	NUM
fnp-3806	998	9	9.4	9.4	NUM
fnp-3806	998	10	years	year	NOUN
fnp-3806	998	11	)	)	PUNCT
fnp-3806	998	12	,	,	PUNCT
fnp-3806	998	13	tau	tau	PROPN
fnp-3806	998	14	pathology	pathology	NOUN
fnp-3806	998	15	was	be	AUX
fnp-3806	998	16	high	high	ADJ
fnp-3806	998	17	in	in	ADP
fnp-3806	998	18	both	both	DET
fnp-3806	998	19	ca1	ca1	NOUN
fnp-3806	998	20	and	and	CCONJ
fnp-3806	998	21	subiculum	subiculum	NOUN
fnp-3806	998	22	,	,	PUNCT
fnp-3806	998	23	followed	follow	VERB
fnp-3806	998	24	by	by	ADP
fnp-3806	998	25	ca2/3	ca2/3	PROPN
fnp-3806	998	26	,	,	PUNCT
fnp-3806	998	27	entorhinal	entorhinal	ADJ
fnp-3806	998	28	cortex	cortex	NOUN
fnp-3806	998	29	,	,	PUNCT
fnp-3806	998	30	ca4	ca4	NOUN
fnp-3806	998	31	,	,	PUNCT
fnp-3806	998	32	and	and	CCONJ
fnp-3806	998	33	dentate	dentate	ADJ
fnp-3806	998	34	gyrus	gyrus	NOUN
fnp-3806	998	35	in	in	ADP
fnp-3806	998	36	sad	sad	ADJ
fnp-3806	998	37	.	.	PUNCT
fnp-3806	999	1	in	in	ADP
fnp-3806	999	2	part	part	NOUN
fnp-3806	999	3	,	,	PUNCT
fnp-3806	999	4	the	the	DET
fnp-3806	999	5	severity	severity	NOUN
fnp-3806	999	6	of	of	ADP
fnp-3806	999	7	tau	tau	PROPN
fnp-3806	999	8	pathology	pathology	NOUN
fnp-3806	999	9	in	in	ADP
fnp-3806	999	10	ca1	ca1	PROPN
fnp-3806	999	11	and	and	CCONJ
fnp-3806	999	12	subiculum	subiculum	NOUN
fnp-3806	999	13	was	be	AUX
fnp-3806	999	14	high	high	ADJ
fnp-3806	999	15	,	,	PUNCT
fnp-3806	999	16	followed	follow	VERB
fnp-3806	999	17	by	by	ADP
fnp-3806	999	18	enthorinal	enthorinal	ADJ
fnp-3806	999	19	cortex	cortex	NOUN
fnp-3806	999	20	,	,	PUNCT
fnp-3806	999	21	ca2/3	ca2/3	PROPN
fnp-3806	999	22	,	,	PUNCT
fnp-3806	999	23	ca4	ca4	NOUN
fnp-3806	999	24	,	,	PUNCT
fnp-3806	999	25	and	and	CCONJ
fnp-3806	999	26	dentate	dentate	ADJ
fnp-3806	999	27	gyrus	gyrus	NOUN
fnp-3806	999	28	(	(	PUNCT
fnp-3806	999	29	1288	1288	NUM
fnp-3806	999	30	)	)	PUNCT
fnp-3806	999	31	.	.	PUNCT
fnp-3806	1000	1	differences	difference	NOUN
fnp-3806	1000	2	appear	appear	VERB
fnp-3806	1000	3	to	to	PART
fnp-3806	1000	4	be	be	AUX
fnp-3806	1000	5	minimal	minimal	ADJ
fnp-3806	1000	6	and	and	CCONJ
fnp-3806	1000	7	were	be	AUX
fnp-3806	1000	8	probably	probably	ADV
fnp-3806	1000	9	modified	modify	VERB
fnp-3806	1000	10	by	by	ADP
fnp-3806	1000	11	the	the	DET
fnp-3806	1000	12	presence	presence	NOUN
fnp-3806	1000	13	of	of	ADP
fnp-3806	1000	14	tau	tau	PROPN
fnp-3806	1000	15	pathology	pathology	NOUN
fnp-3806	1000	16	in	in	ADP
fnp-3806	1000	17	sps	sps	PROPN
fnp-3806	1000	18	in	in	ADP
fnp-3806	1000	19	sad	sad	ADJ
fnp-3806	1000	20	.	.	PUNCT
fnp-3806	1001	1	the	the	DET
fnp-3806	1001	2	proposal	proposal	NOUN
fnp-3806	1001	3	of	of	ADP
fnp-3806	1001	4	part	part	NOUN
fnp-3806	1001	5	as	as	ADP
fnp-3806	1001	6	a	a	DET
fnp-3806	1001	7	new	new	ADJ
fnp-3806	1001	8	tauopathy	tauopathy	NOUN
fnp-3806	1001	9	is	be	AUX
fnp-3806	1001	10	not	not	PART
fnp-3806	1001	11	widely	widely	ADV
fnp-3806	1001	12	accepted	accept	VERB
fnp-3806	1001	13	.	.	PUNCT
fnp-3806	1002	1	part	part	NOUN
fnp-3806	1002	2	has	have	AUX
fnp-3806	1002	3	also	also	ADV
fnp-3806	1002	4	been	be	AUX
fnp-3806	1002	5	interpreted	interpret	VERB
fnp-3806	1002	6	as	as	ADP
fnp-3806	1002	7	being	be	AUX
fnp-3806	1002	8	within	within	ADP
fnp-3806	1002	9	the	the	DET
fnp-3806	1002	10	spectrum	spectrum	NOUN
fnp-3806	1002	11	of	of	ADP
fnp-3806	1002	12	sad	sad	ADJ
fnp-3806	1002	13	(	(	PUNCT
fnp-3806	1002	14	a	a	DET
fnp-3806	1002	15	part	part	NOUN
fnp-3806	1002	16	of	of	ADP
fnp-3806	1002	17	sad	sad	ADJ
fnp-3806	1002	18	)	)	PUNCT
fnp-3806	1002	19	in	in	ADP
fnp-3806	1002	20	cases	case	NOUN
fnp-3806	1002	21	with	with	ADP
fnp-3806	1002	22	a	a	DET
fnp-3806	1002	23	particular	particular	ADJ
fnp-3806	1002	24	genetic	genetic	ADJ
fnp-3806	1002	25	background	background	NOUN
fnp-3806	1002	26	characterized	characterize	VERB
fnp-3806	1002	27	by	by	ADP
fnp-3806	1002	28	lower	low	ADJ
fnp-3806	1002	29	prevalence	prevalence	NOUN
fnp-3806	1002	30	of	of	ADP
fnp-3806	1002	31	apoeε4	apoeε4	PROPN
fnp-3806	1002	32	,	,	PUNCT
fnp-3806	1002	33	ptk2b	ptk2b	PROPN
fnp-3806	1002	34	,	,	PUNCT
fnp-3806	1002	35	bin1	bin1	NOUN
fnp-3806	1002	36	,	,	PUNCT
fnp-3806	1002	37	and	and	CCONJ
fnp-3806	1002	38	cr1	cr1	NOUN
fnp-3806	1002	39	genes	gene	NOUN
fnp-3806	1002	40	,	,	PUNCT
fnp-3806	1002	41	and	and	CCONJ
fnp-3806	1002	42	higher	high	ADJ
fnp-3806	1002	43	prevalence	prevalence	NOUN
fnp-3806	1002	44	of	of	ADP
fnp-3806	1002	45	apoeε2	apoeε2	PROPN
fnp-3806	1002	46	(	(	PUNCT
fnp-3806	1002	47	1282	1282	NUM
fnp-3806	1002	48	,	,	PUNCT
fnp-3806	1002	49	1289	1289	NUM
fnp-3806	1002	50	,	,	PUNCT
fnp-3806	1002	51	1290	1290	NUM
fnp-3806	1002	52	)	)	PUNCT
fnp-3806	1002	53	.	.	PUNCT
fnp-3806	1003	1	in	in	ADP
fnp-3806	1003	2	contrast	contrast	NOUN
fnp-3806	1003	3	,	,	PUNCT
fnp-3806	1003	4	tangle	tangle	NOUN
fnp-3806	1003	5	-	-	PUNCT
fnp-3806	1003	6	predominant	predominant	ADJ
fnp-3806	1003	7	dementia	dementia	NOUN
fnp-3806	1003	8	has	have	AUX
fnp-3806	1003	9	been	be	AUX
fnp-3806	1003	10	associated	associate	VERB
fnp-3806	1003	11	with	with	ADP
fnp-3806	1003	12	mapt	mapt	NOUN
fnp-3806	1003	13	h1	h1	NOUN
fnp-3806	1003	14	haplotype	haplotype	NOUN
fnp-3806	1003	15	(	(	PUNCT
fnp-3806	1003	16	1291	1291	NUM
fnp-3806	1003	17	)	)	PUNCT
fnp-3806	1003	18	.	.	PUNCT
fnp-3806	1004	1	21b	21b	NOUN
fnp-3806	1004	2	.	.	PUNCT
fnp-3806	1005	1	rapidly	rapidly	ADV
fnp-3806	1005	2	progressive	progressive	ADJ
fnp-3806	1005	3	ad	ad	NOUN
fnp-3806	1005	4	patients	patient	NOUN
fnp-3806	1005	5	with	with	ADP
fnp-3806	1005	6	rapidly	rapidly	ADV
fnp-3806	1005	7	progressive	progressive	ADJ
fnp-3806	1005	8	ad	ad	NOUN
fnp-3806	1005	9	(	(	PUNCT
fnp-3806	1005	10	rpad	rpad	NOUN
fnp-3806	1005	11	)	)	PUNCT
fnp-3806	1005	12	are	be	AUX
fnp-3806	1005	13	younger	young	ADJ
fnp-3806	1005	14	and	and	CCONJ
fnp-3806	1005	15	have	have	VERB
fnp-3806	1005	16	a	a	DET
fnp-3806	1005	17	median	median	ADJ
fnp-3806	1005	18	survival	survival	NOUN
fnp-3806	1005	19	time	time	NOUN
fnp-3806	1005	20	after	after	ADP
fnp-3806	1005	21	diagnosis	diagnosis	NOUN
fnp-3806	1005	22	of	of	ADP
fnp-3806	1005	23	about	about	ADV
fnp-3806	1005	24	7	7	NUM
fnp-3806	1005	25	-	-	SYM
fnp-3806	1005	26	10	10	NUM
fnp-3806	1005	27	months	month	NOUN
fnp-3806	1005	28	(	(	PUNCT
fnp-3806	1005	29	1292	1292	NUM
fnp-3806	1005	30	)	)	PUNCT
fnp-3806	1005	31	;	;	PUNCT
fnp-3806	1005	32	the	the	DET
fnp-3806	1005	33	neuropathological	neuropathological	ADJ
fnp-3806	1005	34	hallmarks	hallmark	NOUN
fnp-3806	1005	35	and	and	CCONJ
fnp-3806	1005	36	peripheral	peripheral	ADJ
fnp-3806	1005	37	biomarkers	biomarker	NOUN
fnp-3806	1005	38	are	be	AUX
fnp-3806	1005	39	similar	similar	ADJ
fnp-3806	1005	40	to	to	ADP
fnp-3806	1005	41	those	those	PRON
fnp-3806	1005	42	seen	see	VERB
fnp-3806	1005	43	in	in	ADP
fnp-3806	1005	44	current	current	ADJ
fnp-3806	1005	45	sad	sad	ADJ
fnp-3806	1005	46	excepting	excepting	NOUN
fnp-3806	1005	47	for	for	ADP
fnp-3806	1005	48	a	a	DET
fnp-3806	1005	49	low	low	ADJ
fnp-3806	1005	50	frequency	frequency	NOUN
fnp-3806	1005	51	of	of	ADP
fnp-3806	1005	52	apoeε4	apoeε4	PROPN
fnp-3806	1005	53	allele	allele	PROPN
fnp-3806	1005	54	and	and	CCONJ
fnp-3806	1005	55	increased	increase	VERB
fnp-3806	1005	56	serum	serum	NOUN
fnp-3806	1005	57	levels	level	NOUN
fnp-3806	1005	58	of	of	ADP
fnp-3806	1005	59	specific	specific	ADJ
fnp-3806	1005	60	pro	pro	ADJ
fnp-3806	1005	61	-	-	ADJ
fnp-3806	1005	62	inflammatory	inflammatory	ADJ
fnp-3806	1005	63	cytokines	cytokine	NOUN
fnp-3806	1005	64	(	(	PUNCT
fnp-3806	1005	65	1293	1293	NUM
fnp-3806	1005	66	,	,	PUNCT
fnp-3806	1005	67	1294	1294	NUM
fnp-3806	1005	68	)	)	PUNCT
fnp-3806	1005	69	.	.	PUNCT
fnp-3806	1006	1	yet	yet	ADV
fnp-3806	1006	2	aβ42	aβ42	PROPN
fnp-3806	1006	3	oligomers	oligomer	NOUN
fnp-3806	1006	4	in	in	ADP
fnp-3806	1006	5	rpad	rpad	NOUN
fnp-3806	1006	6	have	have	VERB
fnp-3806	1006	7	distinct	distinct	ADJ
fnp-3806	1006	8	properties	property	NOUN
fnp-3806	1006	9	which	which	PRON
fnp-3806	1006	10	promote	promote	VERB
fnp-3806	1006	11	the	the	DET
fnp-3806	1006	12	faster	fast	ADJ
fnp-3806	1006	13	spread	spread	NOUN
fnp-3806	1006	14	of	of	ADP
fnp-3806	1006	15	aβ42	aβ42	PROPN
fnp-3806	1006	16	pathology	pathology	NOUN
fnp-3806	1006	17	(	(	PUNCT
fnp-3806	1006	18	1295	1295	NUM
fnp-3806	1006	19	)	)	PUNCT
fnp-3806	1006	20	.	.	PUNCT
fnp-3806	1007	1	the	the	DET
fnp-3806	1007	2	composition	composition	NOUN
fnp-3806	1007	3	of	of	ADP
fnp-3806	1007	4	sps	sps	NOUN
fnp-3806	1007	5	also	also	ADV
fnp-3806	1007	6	differs	differ	VERB
fnp-3806	1007	7	in	in	ADP
fnp-3806	1007	8	rpad	rpad	NOUN
fnp-3806	1007	9	,	,	PUNCT
fnp-3806	1007	10	with	with	ADP
fnp-3806	1007	11	significantly	significantly	ADV
fnp-3806	1007	12	higher	high	ADJ
fnp-3806	1007	13	levels	level	NOUN
fnp-3806	1007	14	of	of	ADP
fnp-3806	1007	15	neuronal	neuronal	ADJ
fnp-3806	1007	16	proteins	protein	NOUN
fnp-3806	1007	17	,	,	PUNCT
fnp-3806	1007	18	decreased	decrease	VERB
fnp-3806	1007	19	levels	level	NOUN
fnp-3806	1007	20	of	of	ADP
fnp-3806	1007	21	astrocytic	astrocytic	ADJ
fnp-3806	1007	22	proteins	protein	NOUN
fnp-3806	1007	23	,	,	PUNCT
fnp-3806	1007	24	and	and	CCONJ
fnp-3806	1007	25	particular	particular	ADJ
fnp-3806	1007	26	abundance	abundance	NOUN
fnp-3806	1007	27	of	of	ADP
fnp-3806	1007	28	synaptic	synaptic	ADJ
fnp-3806	1007	29	-	-	PUNCT
fnp-3806	1007	30	derived	derive	VERB
fnp-3806	1007	31	proteins	protein	NOUN
fnp-3806	1007	32	(	(	PUNCT
fnp-3806	1007	33	1296	1296	NUM
fnp-3806	1007	34	)	)	PUNCT
fnp-3806	1007	35	.	.	PUNCT
fnp-3806	1008	1	moreover	moreover	ADV
fnp-3806	1008	2	,	,	PUNCT
fnp-3806	1008	3	high	high	ADJ
fnp-3806	1008	4	-	-	PUNCT
fnp-3806	1008	5	density	density	NOUN
fnp-3806	1008	6	oligomers	oligomer	NOUN
fnp-3806	1008	7	of	of	ADP
fnp-3806	1008	8	the	the	DET
fnp-3806	1008	9	prion	prion	NOUN
fnp-3806	1008	10	protein	protein	NOUN
fnp-3806	1008	11	and	and	CCONJ
fnp-3806	1008	12	a	a	DET
fnp-3806	1008	13	significant	significant	ADJ
fnp-3806	1008	14	1.2	1.2	NUM
fnp-3806	1008	15	-	-	ADJ
fnp-3806	1008	16	fold	fold	ADJ
fnp-3806	1008	17	decrease	decrease	NOUN
fnp-3806	1008	18	in	in	ADP
fnp-3806	1008	19	di	di	NOUN
fnp-3806	1008	20	-	-	PUNCT
fnp-3806	1008	21	glycosylated	glycosylated	ADJ
fnp-3806	1008	22	prp	prp	NOUN
fnp-3806	1008	23	isoforms	isoform	NOUN
fnp-3806	1008	24	occur	occur	VERB
fnp-3806	1008	25	in	in	ADP
fnp-3806	1008	26	rpad	rpad	NOUN
fnp-3806	1008	27	.	.	PUNCT
fnp-3806	1009	1	fifteen	fifteen	NUM
fnp-3806	1009	2	proteins	protein	NOUN
fnp-3806	1009	3	appear	appear	VERB
fnp-3806	1009	4	to	to	PART
fnp-3806	1009	5	interact	interact	VERB
fnp-3806	1009	6	with	with	ADP
fnp-3806	1009	7	prpc	prpc	NOUN
fnp-3806	1009	8	while	while	SCONJ
fnp-3806	1009	9	only	only	ADV
fnp-3806	1009	10	two	two	NUM
fnp-3806	1009	11	proteins	protein	NOUN
fnp-3806	1009	12	,	,	PUNCT
fnp-3806	1009	13	3/4histone	3/4histone	NOUN
fnp-3806	1009	14	h2b	h2b	PROPN
fnp-3806	1009	15	-	-	PUNCT
fnp-3806	1009	16	type1	type1	PROPN
fnp-3806	1009	17	-	-	PUNCT
fnp-3806	1009	18	b	b	PROPN
fnp-3806	1009	19	and	and	CCONJ
fnp-3806	1009	20	zinc	zinc	NOUN
fnp-3806	1009	21	alpha-2	alpha-2	PROPN
fnp-3806	1009	22	protein3/4	protein3/4	NOUN
fnp-3806	1009	23	,	,	PUNCT
fnp-3806	1009	24	are	be	AUX
fnp-3806	1009	25	specifically	specifically	ADV
fnp-3806	1009	26	bound	bind	VERB
fnp-3806	1009	27	with	with	ADP
fnp-3806	1009	28	the	the	DET
fnp-3806	1009	29	prp	prp	NOUN
fnp-3806	1009	30	isoform	isoform	NOUN
fnp-3806	1009	31	isolated	isolate	VERB
fnp-3806	1009	32	from	from	ADP
fnp-3806	1009	33	rpad	rpad	NOUN
fnp-3806	1009	34	cases	case	NOUN
fnp-3806	1009	35	(	(	PUNCT
fnp-3806	1009	36	1297	1297	NUM
fnp-3806	1009	37	)	)	PUNCT
fnp-3806	1009	38	.	.	PUNCT
fnp-3806	1010	1	abnormal	abnormal	ADJ
fnp-3806	1010	2	prp	prp	NOUN
fnp-3806	1010	3	isoforms	isoform	NOUN
fnp-3806	1010	4	in	in	ADP
fnp-3806	1010	5	rpad	rpad	NOUN
fnp-3806	1010	6	are	be	AUX
fnp-3806	1010	7	accompanied	accompany	VERB
fnp-3806	1010	8	by	by	ADP
fnp-3806	1010	9	altered	altered	ADJ
fnp-3806	1010	10	localization	localization	NOUN
fnp-3806	1010	11	of	of	ADP
fnp-3806	1010	12	distinct	distinct	ADJ
fnp-3806	1010	13	interactors	interactor	NOUN
fnp-3806	1010	14	including	include	VERB
fnp-3806	1010	15	the	the	DET
fnp-3806	1010	16	growth	growth	NOUN
fnp-3806	1010	17	arrest	arrest	NOUN
fnp-3806	1010	18	-	-	PUNCT
fnp-3806	1010	19	specific	specific	ADJ
fnp-3806	1010	20	2	2	NUM
fnp-3806	1010	21	-	-	PUNCT
fnp-3806	1010	22	like	like	ADJ
fnp-3806	1010	23	protein	protein	NOUN
fnp-3806	1010	24	and	and	CCONJ
fnp-3806	1010	25	associated	associate	VERB
fnp-3806	1010	26	end	end	NOUN
fnp-3806	1010	27	-	-	PUNCT
fnp-3806	1010	28	binding	bind	VERB
fnp-3806	1010	29	protein	protein	NOUN
fnp-3806	1010	30	1	1	NUM
fnp-3806	1010	31	,	,	PUNCT
fnp-3806	1010	32	α	α	NOUN
fnp-3806	1010	33	-	-	PUNCT
fnp-3806	1010	34	tubulin	tubulin	NOUN
fnp-3806	1010	35	,	,	PUNCT
fnp-3806	1010	36	and	and	CCONJ
fnp-3806	1010	37	β	β	X
fnp-3806	1010	38	-	-	NOUN
fnp-3806	1010	39	actin	actin	NOUN
fnp-3806	1010	40	(	(	PUNCT
fnp-3806	1010	41	1298	1298	NUM
fnp-3806	1010	42	)	)	PUNCT
fnp-3806	1010	43	.	.	PUNCT
fnp-3806	1011	1	molecular	molecular	ADJ
fnp-3806	1011	2	profiles	profile	NOUN
fnp-3806	1011	3	of	of	ADP
fnp-3806	1011	4	β	β	NOUN
fnp-3806	1011	5	-	-	ADJ
fnp-3806	1011	6	amyloid	amyloid	ADJ
fnp-3806	1011	7	proteoforms	proteoform	NOUN
fnp-3806	1011	8	differ	differ	VERB
fnp-3806	1011	9	in	in	ADP
fnp-3806	1011	10	rpad	rpad	NOUN
fnp-3806	1011	11	when	when	SCONJ
fnp-3806	1011	12	compared	compare	VERB
fnp-3806	1011	13	with	with	ADP
fnp-3806	1011	14	typical	typical	ADJ
fnp-3806	1011	15	sad	sad	ADJ
fnp-3806	1011	16	(	(	PUNCT
fnp-3806	1011	17	1299	1299	NUM
fnp-3806	1011	18	)	)	PUNCT
fnp-3806	1011	19	.	.	PUNCT
fnp-3806	1012	1	moreover	moreover	ADV
fnp-3806	1012	2	,	,	PUNCT
fnp-3806	1012	3	the	the	DET
fnp-3806	1012	4	presence	presence	NOUN
fnp-3806	1012	5	of	of	ADP
fnp-3806	1012	6	highly	highly	ADV
fnp-3806	1012	7	hydrophobic	hydrophobic	ADJ
fnp-3806	1012	8	aβ	aβ	NOUN
fnp-3806	1012	9	seeds	seed	NOUN
fnp-3806	1012	10	in	in	ADP
fnp-3806	1012	11	rpad	rpad	NOUN
fnp-3806	1012	12	brains	brain	NOUN
fnp-3806	1012	13	that	that	PRON
fnp-3806	1012	14	seeded	seed	VERB
fnp-3806	1012	15	reactions	reaction	NOUN
fnp-3806	1012	16	at	at	ADP
fnp-3806	1012	17	a	a	DET
fnp-3806	1012	18	slower	slow	ADJ
fnp-3806	1012	19	pace	pace	NOUN
fnp-3806	1012	20	in	in	ADP
fnp-3806	1012	21	comparison	comparison	NOUN
fnp-3806	1012	22	to	to	ADP
fnp-3806	1012	23	typical	typical	ADJ
fnp-3806	1012	24	sad	sad	ADJ
fnp-3806	1012	25	has	have	AUX
fnp-3806	1012	26	been	be	AUX
fnp-3806	1012	27	validated	validate	VERB
fnp-3806	1012	28	(	(	PUNCT
fnp-3806	1012	29	1299	1299	NUM
fnp-3806	1012	30	)	)	PUNCT
fnp-3806	1012	31	.	.	PUNCT
fnp-3806	1013	1	another	another	DET
fnp-3806	1013	2	anomaly	anomaly	NOUN
fnp-3806	1013	3	is	be	AUX
fnp-3806	1013	4	the	the	DET
fnp-3806	1013	5	downregulation	downregulation	NOUN
fnp-3806	1013	6	and	and	CCONJ
fnp-3806	1013	7	dislocalization	dislocalization	NOUN
fnp-3806	1013	8	from	from	ADP
fnp-3806	1013	9	the	the	DET
fnp-3806	1013	10	nucleus	nucleus	NOUN
fnp-3806	1013	11	to	to	ADP
fnp-3806	1013	12	the	the	DET
fnp-3806	1013	13	cytoplasm	cytoplasm	NOUN
fnp-3806	1013	14	of	of	ADP
fnp-3806	1013	15	the	the	DET
fnp-3806	1013	16	splicing	splicing	NOUN
fnp-3806	1013	17	factor	factor	NOUN
fnp-3806	1013	18	proline	proline	NOUN
fnp-3806	1013	19	and	and	CCONJ
fnp-3806	1013	20	glutamine	glutamine	NOUN
fnp-3806	1013	21	rich	rich	ADJ
fnp-3806	1013	22	(	(	PUNCT
fnp-3806	1013	23	sfpq	sfpq	NOUN
fnp-3806	1013	24	)	)	PUNCT
fnp-3806	1013	25	,	,	PUNCT
fnp-3806	1013	26	its	its	PRON
fnp-3806	1013	27	colocalization	colocalization	NOUN
fnp-3806	1013	28	with	with	ADP
fnp-3806	1013	29	tia-1	tia-1	VERB
fnp-3806	1013	30	in	in	ADP
fnp-3806	1013	31	stress	stress	ADJ
fnp-3806	1013	32	granules	granule	NOUN
fnp-3806	1013	33	,	,	PUNCT
fnp-3806	1013	34	and	and	CCONJ
fnp-3806	1013	35	its	its	PRON
fnp-3806	1013	36	association	association	NOUN
fnp-3806	1013	37	with	with	ADP
fnp-3806	1013	38	tau	tau	PROPN
fnp-3806	1013	39	oligomers	oligomer	NOUN
fnp-3806	1013	40	in	in	ADP
fnp-3806	1013	41	the	the	DET
fnp-3806	1013	42	brain	brain	NOUN
fnp-3806	1013	43	of	of	ADP
fnp-3806	1013	44	rpad	rpad	PROPN
fnp-3806	1013	45	(	(	PUNCT
fnp-3806	1013	46	1300	1300	NUM
fnp-3806	1013	47	)	)	PUNCT
fnp-3806	1013	48	.	.	PUNCT
fnp-3806	1014	1	21c	21c	NUM
fnp-3806	1014	2	.	.	PUNCT
fnp-3806	1015	1	sad	sad	ADJ
fnp-3806	1015	2	resilience	resilience	NOUN
fnp-3806	1015	3	centenarians	centenarian	NOUN
fnp-3806	1015	4	have	have	VERB
fnp-3806	1015	5	resistance	resistance	NOUN
fnp-3806	1015	6	to	to	ADP
fnp-3806	1015	7	sad	sad	ADJ
fnp-3806	1015	8	or	or	CCONJ
fnp-3806	1015	9	very	very	ADV
fnp-3806	1015	10	low	low	ADJ
fnp-3806	1015	11	progression	progression	NOUN
fnp-3806	1015	12	to	to	ADP
fnp-3806	1015	13	advanced	advanced	ADJ
fnp-3806	1015	14	braak	braak	NOUN
fnp-3806	1015	15	stages	stage	NOUN
fnp-3806	1015	16	of	of	ADP
fnp-3806	1015	17	tau	tau	PROPN
fnp-3806	1015	18	and	and	CCONJ
fnp-3806	1015	19	β	β	NOUN
fnp-3806	1015	20	-	-	ADJ
fnp-3806	1015	21	amyloid	amyloid	ADJ
fnp-3806	1015	22	pathology	pathology	NOUN
fnp-3806	1015	23	(	(	PUNCT
fnp-3806	1015	24	1301	1301	NUM
fnp-3806	1015	25	-	-	SYM
fnp-3806	1015	26	1303	1303	NUM
fnp-3806	1015	27	)	)	PUNCT
fnp-3806	1015	28	.	.	PUNCT
fnp-3806	1016	1	curiously	curiously	ADV
fnp-3806	1016	2	,	,	PUNCT
fnp-3806	1016	3	ad	ad	NOUN
fnp-3806	1016	4	-	-	PUNCT
fnp-3806	1016	5	related	relate	VERB
fnp-3806	1016	6	changes	change	NOUN
fnp-3806	1016	7	in	in	ADP
fnp-3806	1016	8	the	the	DET
fnp-3806	1016	9	oldest	oldest	ADV
fnp-3806	1016	10	-	-	PUNCT
fnp-3806	1016	11	old	old	ADJ
fnp-3806	1016	12	population	population	NOUN
fnp-3806	1016	13	also	also	ADV
fnp-3806	1016	14	show	show	VERB
fnp-3806	1016	15	a	a	DET
fnp-3806	1016	16	particular	particular	ADJ
fnp-3806	1016	17	neuropathological	neuropathological	ADJ
fnp-3806	1016	18	distribution	distribution	NOUN
fnp-3806	1016	19	including	include	VERB
fnp-3806	1016	20	high	high	ADJ
fnp-3806	1016	21	densities	density	NOUN
fnp-3806	1016	22	of	of	ADP
fnp-3806	1016	23	nfts	nft	NOUN
fnp-3806	1016	24	,	,	PUNCT
fnp-3806	1016	25	mainly	mainly	ADV
fnp-3806	1016	26	in	in	ADP
fnp-3806	1016	27	the	the	DET
fnp-3806	1016	28	hippocampus	hippocampus	NOUN
fnp-3806	1016	29	,	,	PUNCT
fnp-3806	1016	30	without	without	ADP
fnp-3806	1016	31	apparent	apparent	ADJ
fnp-3806	1016	32	major	major	ADJ
fnp-3806	1016	33	clinical	clinical	ADJ
fnp-3806	1016	34	deficiencies	deficiency	NOUN
fnp-3806	1016	35	(	(	PUNCT
fnp-3806	1016	36	1302	1302	NUM
fnp-3806	1016	37	-	-	SYM
fnp-3806	1016	38	1307	1307	NUM
fnp-3806	1016	39	)	)	PUNCT
fnp-3806	1016	40	.	.	PUNCT
fnp-3806	1017	1	multiple	multiple	ADJ
fnp-3806	1017	2	factors	factor	NOUN
fnp-3806	1017	3	are	be	AUX
fnp-3806	1017	4	associated	associate	VERB
fnp-3806	1017	5	with	with	ADP
fnp-3806	1017	6	increased	increase	VERB
fnp-3806	1017	7	or	or	CCONJ
fnp-3806	1017	8	reduced	reduce	VERB
fnp-3806	1017	9	structural	structural	ADJ
fnp-3806	1017	10	and	and	CCONJ
fnp-3806	1017	11	behavioral	behavioral	ADJ
fnp-3806	1017	12	patterns	pattern	NOUN
fnp-3806	1017	13	linked	link	VERB
fnp-3806	1017	14	to	to	ADP
fnp-3806	1017	15	cognition	cognition	NOUN
fnp-3806	1017	16	in	in	ADP
fnp-3806	1017	17	the	the	DET
fnp-3806	1017	18	elderly	elderly	ADJ
fnp-3806	1017	19	and	and	CCONJ
fnp-3806	1017	20	sad	sad	ADJ
fnp-3806	1017	21	.	.	PUNCT
fnp-3806	1018	1	the	the	DET
fnp-3806	1018	2	cognitive	cognitive	ADJ
fnp-3806	1018	3	reserve	reserve	PROPN
fnp-3806	1018	4	,	,	PUNCT
fnp-3806	1018	5	linked	link	VERB
fnp-3806	1018	6	to	to	ADP
fnp-3806	1018	7	educational	educational	ADJ
fnp-3806	1018	8	and	and	CCONJ
fnp-3806	1018	9	occupational	occupational	ADJ
fnp-3806	1018	10	acquisition	acquisition	NOUN
fnp-3806	1018	11	,	,	PUNCT
fnp-3806	1018	12	social	social	ADJ
fnp-3806	1018	13	networks	network	NOUN
fnp-3806	1018	14	,	,	PUNCT
fnp-3806	1018	15	and	and	CCONJ
fnp-3806	1018	16	leisure	leisure	NOUN
fnp-3806	1018	17	activities	activity	NOUN
fnp-3806	1018	18	in	in	ADP
fnp-3806	1018	19	later	later	ADJ
fnp-3806	1018	20	life	life	NOUN
fnp-3806	1018	21	,	,	PUNCT
fnp-3806	1018	22	have	have	VERB
fnp-3806	1018	23	a	a	DET
fnp-3806	1018	24	protective	protective	ADJ
fnp-3806	1018	25	effect	effect	NOUN
fnp-3806	1018	26	(	(	PUNCT
fnp-3806	1018	27	1308	1308	NUM
fnp-3806	1018	28	-	-	SYM
fnp-3806	1018	29	1312	1312	NUM
fnp-3806	1018	30	)	)	PUNCT
fnp-3806	1018	31	.	.	PUNCT
fnp-3806	1019	1	glycolitic	glycolitic	ADJ
fnp-3806	1019	2	dysfunction	dysfunction	NOUN
fnp-3806	1019	3	reduces	reduce	VERB
fnp-3806	1019	4	resilience	resilience	NOUN
fnp-3806	1019	5	(	(	PUNCT
fnp-3806	1019	6	1313	1313	NUM
fnp-3806	1019	7	)	)	PUNCT
fnp-3806	1019	8	whereas	whereas	SCONJ
fnp-3806	1019	9	coffee	coffee	NOUN
fnp-3806	1019	10	and	and	CCONJ
fnp-3806	1019	11	cacao	cacao	VERB
fnp-3806	1019	12	favour	favour	NOUN
fnp-3806	1019	13	protection	protection	NOUN
fnp-3806	1019	14	from	from	ADP
fnp-3806	1019	15	sad	sad	ADJ
fnp-3806	1019	16	(	(	PUNCT
fnp-3806	1019	17	1314	1314	NUM
fnp-3806	1019	18	)	)	PUNCT
fnp-3806	1019	19	.	.	PUNCT
fnp-3806	1020	1	comorbidities	comorbiditie	NOUN
fnp-3806	1020	2	,	,	PUNCT
fnp-3806	1020	3	including	include	VERB
fnp-3806	1020	4	tdp-43	tdp-43	NOUN
fnp-3806	1020	5	proteinopathy	proteinopathy	ADJ
fnp-3806	1020	6	and	and	CCONJ
fnp-3806	1020	7	mesial	mesial	ADJ
fnp-3806	1020	8	sclerosis	sclerosis	NOUN
fnp-3806	1020	9	,	,	PUNCT
fnp-3806	1020	10	reduce	reduce	VERB
fnp-3806	1020	11	resilience	resilience	NOUN
fnp-3806	1020	12	(	(	PUNCT
fnp-3806	1020	13	1315	1315	NUM
fnp-3806	1020	14	-	-	SYM
fnp-3806	1020	15	1317	1317	NUM
fnp-3806	1020	16	)	)	PUNCT
fnp-3806	1020	17	.	.	PUNCT
fnp-3806	1021	1	genetic	genetic	ADJ
fnp-3806	1021	2	factors	factor	NOUN
fnp-3806	1021	3	also	also	ADV
fnp-3806	1021	4	participate	participate	VERB
fnp-3806	1021	5	in	in	ADP
fnp-3806	1021	6	cognitive	cognitive	ADJ
fnp-3806	1021	7	resilience	resilience	NOUN
fnp-3806	1021	8	(	(	PUNCT
fnp-3806	1021	9	1318	1318	NUM
fnp-3806	1021	10	,	,	PUNCT
fnp-3806	1021	11	1319	1319	NUM
fnp-3806	1021	12	)	)	PUNCT
fnp-3806	1021	13	.	.	PUNCT
fnp-3806	1022	1	a	a	DET
fnp-3806	1022	2	greater	great	ADJ
fnp-3806	1022	3	number	number	NOUN
fnp-3806	1022	4	of	of	ADP
fnp-3806	1022	5	genes	gene	NOUN
fnp-3806	1022	6	apply	apply	VERB
fnp-3806	1022	7	in	in	ADP
fnp-3806	1022	8	women	woman	NOUN
fnp-3806	1022	9	(	(	PUNCT
fnp-3806	1022	10	225	225	NUM
fnp-3806	1022	11	,	,	PUNCT
fnp-3806	1022	12	1320	1320	NUM
fnp-3806	1022	13	)	)	PUNCT
fnp-3806	1022	14	.	.	PUNCT
fnp-3806	1023	1	a	a	DET
fnp-3806	1023	2	top	top	ADJ
fnp-3806	1023	3	variant	variant	NOUN
fnp-3806	1023	4	on	on	ADP
fnp-3806	1023	5	chromosome	chromosome	NOUN
fnp-3806	1023	6	18	18	NUM
fnp-3806	1023	7	upstream	upstream	NOUN
fnp-3806	1023	8	of	of	ADP
fnp-3806	1023	9	atp8b1	atp8b1	PROPN
fnp-3806	1023	10	is	be	AUX
fnp-3806	1023	11	significantly	significantly	ADV
fnp-3806	1023	12	associated	associate	VERB
fnp-3806	1023	13	with	with	ADP
fnp-3806	1023	14	methylation	methylation	NOUN
fnp-3806	1023	15	in	in	ADP
fnp-3806	1023	16	prefrontal	prefrontal	ADJ
fnp-3806	1023	17	cortex	cortex	NOUN
fnp-3806	1023	18	tissue	tissue	NOUN
fnp-3806	1023	19	at	at	ADP
fnp-3806	1023	20	multiple	multiple	ADJ
fnp-3806	1023	21	cpg	cpg	NOUN
fnp-3806	1023	22	sites	site	NOUN
fnp-3806	1023	23	,	,	PUNCT
fnp-3806	1023	24	including	include	VERB
fnp-3806	1023	25	one	one	NUM
fnp-3806	1023	26	just	just	ADV
fnp-3806	1023	27	upstream	upstream	ADV
fnp-3806	1023	28	of	of	ADP
fnp-3806	1023	29	atpb81	atpb81	NOUN
fnp-3806	1023	30	,	,	PUNCT
fnp-3806	1023	31	and	and	CCONJ
fnp-3806	1023	32	present	present	ADJ
fnp-3806	1023	33	in	in	ADP
fnp-3806	1023	34	individuals	individual	NOUN
fnp-3806	1023	35	with	with	ADP
fnp-3806	1023	36	unimpaired	unimpaired	ADJ
fnp-3806	1023	37	cognition	cognition	NOUN
fnp-3806	1023	38	(	(	PUNCT
fnp-3806	1023	39	1321	1321	NUM
fnp-3806	1023	40	)	)	PUNCT
fnp-3806	1023	41	.	.	PUNCT
fnp-3806	1024	1	a	a	DET
fnp-3806	1024	2	rare	rare	ADJ
fnp-3806	1024	3	variant	variant	NOUN
fnp-3806	1024	4	in	in	ADP
fnp-3806	1024	5	the	the	DET
fnp-3806	1024	6	3'-utr	3'-utr	PROPN
fnp-3806	1024	7	of	of	ADP
fnp-3806	1024	8	rab10	rab10	NOUN
fnp-3806	1024	9	is	be	AUX
fnp-3806	1024	10	protective	protective	ADJ
fnp-3806	1024	11	for	for	ADP
fnp-3806	1024	12	sad	sad	ADJ
fnp-3806	1024	13	(	(	PUNCT
fnp-3806	1024	14	1322	1322	NUM
fnp-3806	1024	15	)	)	PUNCT
fnp-3806	1024	16	.	.	PUNCT
fnp-3806	1025	1	hdac4	hdac4	NOUN
fnp-3806	1025	2	,	,	PUNCT
fnp-3806	1025	3	rest	rest	NOUN
fnp-3806	1025	4	,	,	PUNCT
fnp-3806	1025	5	and	and	CCONJ
fnp-3806	1025	6	gi	gi	VERB
fnp-3806	1025	7	intracellular	intracellular	ADJ
fnp-3806	1025	8	signaling	signal	VERB
fnp-3806	1025	9	are	be	AUX
fnp-3806	1025	10	sad	sad	ADJ
fnp-3806	1025	11	-	-	PUNCT
fnp-3806	1025	12	specific	specific	ADJ
fnp-3806	1025	13	pathways	pathway	NOUN
fnp-3806	1025	14	involved	involve	VERB
fnp-3806	1025	15	in	in	ADP
fnp-3806	1025	16	regulating	regulate	VERB
fnp-3806	1025	17	the	the	DET
fnp-3806	1025	18	onset	onset	NOUN
fnp-3806	1025	19	of	of	ADP
fnp-3806	1025	20	memory	memory	NOUN
fnp-3806	1025	21	deficits	deficit	NOUN
fnp-3806	1025	22	(	(	PUNCT
fnp-3806	1025	23	1323	1323	NUM
fnp-3806	1025	24	)	)	PUNCT
fnp-3806	1025	25	.	.	PUNCT
fnp-3806	1026	1	molecular	molecular	ADJ
fnp-3806	1026	2	modulators	modulator	NOUN
fnp-3806	1026	3	of	of	ADP
fnp-3806	1026	4	neuronal	neuronal	ADJ
fnp-3806	1026	5	vulnerability	vulnerability	NOUN
fnp-3806	1026	6	,	,	PUNCT
fnp-3806	1026	7	such	such	ADJ
fnp-3806	1026	8	as	as	ADP
fnp-3806	1026	9	rar	rar	NOUN
fnp-3806	1026	10	related	relate	VERB
fnp-3806	1026	11	orphan	orphan	NOUN
fnp-3806	1026	12	receptor	receptor	NOUN
fnp-3806	1026	13	b	b	PROPN
fnp-3806	1026	14	(	(	PUNCT
fnp-3806	1026	15	rorb	rorb	NOUN
fnp-3806	1026	16	)	)	PUNCT
fnp-3806	1026	17	,	,	PUNCT
fnp-3806	1026	18	and	and	CCONJ
fnp-3806	1026	19	glial	glial	ADJ
fnp-3806	1026	20	dysfunctions	dysfunction	NOUN
fnp-3806	1026	21	are	be	AUX
fnp-3806	1026	22	also	also	ADV
fnp-3806	1026	23	involved	involve	VERB
fnp-3806	1026	24	in	in	ADP
fnp-3806	1026	25	neuronal	neuronal	ADJ
fnp-3806	1026	26	vulnerability	vulnerability	NOUN
fnp-3806	1026	27	(	(	PUNCT
fnp-3806	1026	28	1324	1324	NUM
fnp-3806	1026	29	)	)	PUNCT
fnp-3806	1026	30	.	.	PUNCT
fnp-3806	1027	1	the	the	DET
fnp-3806	1027	2	myocyte	myocyte	NOUN
fnp-3806	1027	3	-	-	PUNCT
fnp-3806	1027	4	specific	specific	ADJ
fnp-3806	1027	5	enhancer	enhancer	NOUN
fnp-3806	1027	6	factor	factor	NOUN
fnp-3806	1027	7	2c	2c	NOUN
fnp-3806	1027	8	(	(	PUNCT
fnp-3806	1027	9	mef2c	mef2c	PROPN
fnp-3806	1027	10	)	)	PUNCT
fnp-3806	1027	11	is	be	AUX
fnp-3806	1027	12	upregulated	upregulate	VERB
fnp-3806	1027	13	in	in	ADP
fnp-3806	1027	14	a	a	DET
fnp-3806	1027	15	subpopulation	subpopulation	NOUN
fnp-3806	1027	16	of	of	ADP
fnp-3806	1027	17	glutamatergic	glutamatergic	ADJ
fnp-3806	1027	18	neurons	neuron	NOUN
fnp-3806	1027	19	in	in	ADP
fnp-3806	1027	20	resilient	resilient	ADJ
fnp-3806	1027	21	individuals	individual	NOUN
fnp-3806	1027	22	.	.	PUNCT
fnp-3806	1028	1	over	over	ADP
fnp-3806	1028	2	-	-	PUNCT
fnp-3806	1028	3	expression	expression	NOUN
fnp-3806	1028	4	of	of	ADP
fnp-3806	1028	5	mef2a	mef2a	PUNCT
fnp-3806	1028	6	/	/	SYM
fnp-3806	1028	7	c	c	NOUN
fnp-3806	1028	8	in	in	ADP
fnp-3806	1028	9	the	the	DET
fnp-3806	1028	10	ps19	ps19	PROPN
fnp-3806	1028	11	transgenic	transgenic	NOUN
fnp-3806	1028	12	mouse	mouse	NOUN
fnp-3806	1028	13	model	model	NOUN
fnp-3806	1028	14	of	of	ADP
fnp-3806	1028	15	tauopathy	tauopathy	NOUN
fnp-3806	1028	16	improves	improve	VERB
fnp-3806	1028	17	cognitive	cognitive	ADJ
fnp-3806	1028	18	flexibility	flexibility	NOUN
fnp-3806	1028	19	and	and	CCONJ
fnp-3806	1028	20	reduces	reduce	VERB
fnp-3806	1028	21	hyperexcitability	hyperexcitability	NOUN
fnp-3806	1028	22	(	(	PUNCT
fnp-3806	1028	23	1325	1325	NUM
fnp-3806	1028	24	)	)	PUNCT
fnp-3806	1028	25	.	.	PUNCT
fnp-3806	1029	1	the	the	DET
fnp-3806	1029	2	profiles	profile	NOUN
fnp-3806	1029	3	of	of	ADP
fnp-3806	1029	4	brain	brain	NOUN
fnp-3806	1029	5	inflammatory	inflammatory	ADJ
fnp-3806	1029	6	responses	response	NOUN
fnp-3806	1029	7	also	also	ADV
fnp-3806	1029	8	differ	differ	VERB
fnp-3806	1029	9	in	in	ADP
fnp-3806	1029	10	resilient	resilient	ADJ
fnp-3806	1029	11	sad	sad	ADJ
fnp-3806	1029	12	cases	case	NOUN
fnp-3806	1029	13	,	,	PUNCT
fnp-3806	1029	14	with	with	ADP
fnp-3806	1029	15	expression	expression	NOUN
fnp-3806	1029	16	levels	level	NOUN
fnp-3806	1029	17	of	of	ADP
fnp-3806	1029	18	chemokines	chemokine	NOUN
fnp-3806	1029	19	decreasing	decrease	VERB
fnp-3806	1029	20	and	and	CCONJ
fnp-3806	1029	21	trophic	trophic	ADJ
fnp-3806	1029	22	factors	factor	NOUN
fnp-3806	1029	23	increasing	increase	VERB
fnp-3806	1029	24	(	(	PUNCT
fnp-3806	1029	25	860	860	NUM
fnp-3806	1029	26	,	,	PUNCT
fnp-3806	1029	27	1326	1326	NUM
fnp-3806	1029	28	)	)	PUNCT
fnp-3806	1029	29	.	.	PUNCT
fnp-3806	1030	1	yet	yet	CCONJ
fnp-3806	1030	2	a	a	DET
fnp-3806	1030	3	consensus	consensus	NOUN
fnp-3806	1030	4	is	be	AUX
fnp-3806	1030	5	needed	need	VERB
fnp-3806	1030	6	on	on	ADP
fnp-3806	1030	7	how	how	SCONJ
fnp-3806	1030	8	to	to	PART
fnp-3806	1030	9	define	define	VERB
fnp-3806	1030	10	the	the	DET
fnp-3806	1030	11	concepts	concept	NOUN
fnp-3806	1030	12	of	of	ADP
fnp-3806	1030	13	cognitive	cognitive	ADJ
fnp-3806	1030	14	reserve	reserve	PROPN
fnp-3806	1030	15	,	,	PUNCT
fnp-3806	1030	16	resilience	resilience	NOUN
fnp-3806	1030	17	,	,	PUNCT
fnp-3806	1030	18	and	and	CCONJ
fnp-3806	1030	19	resistance	resistance	NOUN
fnp-3806	1030	20	linked	link	VERB
fnp-3806	1030	21	to	to	ADP
fnp-3806	1030	22	cognition	cognition	NOUN
fnp-3806	1030	23	in	in	ADP
fnp-3806	1030	24	aged	aged	ADJ
fnp-3806	1030	25	individuals	individual	NOUN
fnp-3806	1030	26	(	(	PUNCT
fnp-3806	1030	27	1327	1327	NUM
fnp-3806	1030	28	)	)	PUNCT
fnp-3806	1030	29	.	.	PUNCT
fnp-3806	1031	1	the	the	DET
fnp-3806	1031	2	genetic	genetic	ADJ
fnp-3806	1031	3	and	and	CCONJ
fnp-3806	1031	4	molecular	molecular	ADJ
fnp-3806	1031	5	factors	factor	NOUN
fnp-3806	1031	6	linked	link	VERB
fnp-3806	1031	7	to	to	ADP
fnp-3806	1031	8	the	the	DET
fnp-3806	1031	9	ad	ad	NOUN
fnp-3806	1031	10	spectrum	spectrum	NOUN
fnp-3806	1031	11	are	be	AUX
fnp-3806	1031	12	listed	list	VERB
fnp-3806	1031	13	in	in	ADP
fnp-3806	1031	14	table	table	NOUN
fnp-3806	1031	15	3	3	NUM
fnp-3806	1031	16	.	.	PUNCT
fnp-3806	1032	1	fad	fad	NOUN
fnp-3806	1032	2	mutations	mutation	NOUN
fnp-3806	1032	3	in	in	ADP
fnp-3806	1032	4	the	the	DET
fnp-3806	1032	5	genes	gene	NOUN
fnp-3806	1032	6	app	app	VERB
fnp-3806	1032	7	,	,	PUNCT
fnp-3806	1032	8	psen1	psen1	ADJ
fnp-3806	1032	9	(	(	PUNCT
fnp-3806	1032	10	presenilin1	presenilin1	NOUN
fnp-3806	1032	11	)	)	PUNCT
fnp-3806	1032	12	,	,	PUNCT
fnp-3806	1032	13	and	and	CCONJ
fnp-3806	1032	14	psen2	psen2	NOUN
fnp-3806	1032	15	;	;	PUNCT
fnp-3806	1032	16	increased	increase	VERB
fnp-3806	1032	17	app	app	NOUN
fnp-3806	1032	18	dosage	dosage	NOUN
fnp-3806	1032	19	sad	sad	PROPN
fnp-3806	1032	20	ε4	ε4	NOUN
fnp-3806	1032	21	of	of	ADP
fnp-3806	1032	22	apoe	apoe	PROPN
fnp-3806	1032	23	,	,	PUNCT
fnp-3806	1032	24	lrp1	lrp1	PROPN
fnp-3806	1032	25	,	,	PUNCT
fnp-3806	1032	26	ldlr	ldlr	NOUN
fnp-3806	1032	27	,	,	PUNCT
fnp-3806	1032	28	interleukin	interleukin	NOUN
fnp-3806	1032	29	1a	1a	NOUN
fnp-3806	1032	30	,	,	PUNCT
fnp-3806	1032	31	clu	clu	PROPN
fnp-3806	1032	32	,	,	PUNCT
fnp-3806	1032	33	picalm	picalm	ADJ
fnp-3806	1032	34	,	,	PUNCT
fnp-3806	1032	35	cr1	cr1	PROPN
fnp-3806	1032	36	,	,	PUNCT
fnp-3806	1032	37	bin1	bin1	PROPN
fnp-3806	1032	38	,	,	PUNCT
fnp-3806	1032	39	trem2	trem2	NOUN
fnp-3806	1032	40	,	,	PUNCT
fnp-3806	1032	41	sorl1	sorl1	PROPN
fnp-3806	1032	42	,	,	PUNCT
fnp-3806	1032	43	adam10	adam10	NOUN
fnp-3806	1032	44	,	,	PUNCT
fnp-3806	1032	45	abca7	abca7	PROPN
fnp-3806	1032	46	,	,	PUNCT
fnp-3806	1032	47	spi1	spi1	PROPN
fnp-3806	1032	48	,	,	PUNCT
fnp-3806	1032	49	pilra	pilra	X
fnp-3806	1032	50	,	,	PUNCT
fnp-3806	1032	51	msa4	msa4	NOUN
fnp-3806	1032	52	,	,	PUNCT
fnp-3806	1032	53	cd2ap	cd2ap	NOUN
fnp-3806	1032	54	,	,	PUNCT
fnp-3806	1032	55	and	and	CCONJ
fnp-3806	1032	56	epha1	epha1	VERB
fnp-3806	1032	57	part	part	NOUN
fnp-3806	1032	58	lower	low	ADJ
fnp-3806	1032	59	prevalence	prevalence	NOUN
fnp-3806	1032	60	of	of	ADP
fnp-3806	1032	61	apoeε4	apoeε4	PROPN
fnp-3806	1032	62	,	,	PUNCT
fnp-3806	1032	63	ptk2b	ptk2b	PROPN
fnp-3806	1032	64	,	,	PUNCT
fnp-3806	1032	65	bin1	bin1	NOUN
fnp-3806	1032	66	,	,	PUNCT
fnp-3806	1032	67	and	and	CCONJ
fnp-3806	1032	68	cr1	cr1	NOUN
fnp-3806	1032	69	genes	gene	NOUN
fnp-3806	1032	70	,	,	PUNCT
fnp-3806	1032	71	and	and	CCONJ
fnp-3806	1032	72	higher	high	ADJ
fnp-3806	1032	73	prevalence	prevalence	NOUN
fnp-3806	1032	74	of	of	ADP
fnp-3806	1032	75	apoeε2	apoeε2	PROPN
fnp-3806	1032	76	rpad	rpad	NOUN
fnp-3806	1032	77	low	low	PROPN
fnp-3806	1032	78	frequency	frequency	NOUN
fnp-3806	1032	79	of	of	ADP
fnp-3806	1032	80	apoeε4	apoeε4	PROPN
fnp-3806	1032	81	allele	allele	PROPN
fnp-3806	1032	82	;	;	PUNCT
fnp-3806	1032	83	increased	increase	VERB
fnp-3806	1032	84	inflammation	inflammation	NOUN
fnp-3806	1032	85	;	;	PUNCT
fnp-3806	1032	86	different	different	ADJ
fnp-3806	1032	87	aβ	aβ	PRON
fnp-3806	1032	88	oligomers	oligomer	NOUN
fnp-3806	1032	89	;	;	PUNCT
fnp-3806	1032	90	different	different	ADJ
fnp-3806	1032	91	amyloid‑β	amyloid‑β	NOUN
fnp-3806	1032	92	proteoforms	proteoform	VERB
fnp-3806	1032	93	;	;	PUNCT
fnp-3806	1032	94	different	different	ADJ
fnp-3806	1032	95	seeding	seeding	NOUN
fnp-3806	1032	96	capacities	capacity	NOUN
fnp-3806	1032	97	of	of	ADP
fnp-3806	1032	98	β	β	NOUN
fnp-3806	1032	99	-	-	NOUN
fnp-3806	1032	100	amyloid	amyloid	NOUN
fnp-3806	1032	101	;	;	PUNCT
fnp-3806	1032	102	high	high	ADJ
fnp-3806	1032	103	-	-	PUNCT
fnp-3806	1032	104	density	density	NOUN
fnp-3806	1032	105	prp	prp	NOUN
fnp-3806	1032	106	oligomers	oligomer	NOUN
fnp-3806	1032	107	;	;	PUNCT
fnp-3806	1032	108	decreased	decrease	VERB
fnp-3806	1032	109	prp	prp	PROPN
fnp-3806	1032	110	di	di	NOUN
fnp-3806	1032	111	-	-	PUNCT
fnp-3806	1032	112	glycosylated	glycosylated	ADJ
fnp-3806	1032	113	isoforms	isoform	NOUN
fnp-3806	1032	114	;	;	PUNCT
fnp-3806	1032	115	specific	specific	ADJ
fnp-3806	1032	116	prp	prp	NOUN
fnp-3806	1032	117	isoform	isoform	NOUN
fnp-3806	1032	118	;	;	PUNCT
fnp-3806	1032	119	altered	alter	VERB
fnp-3806	1032	120	localization	localization	NOUN
fnp-3806	1032	121	of	of	ADP
fnp-3806	1032	122	the	the	DET
fnp-3806	1032	123	growth	growth	NOUN
fnp-3806	1032	124	arrest	arrest	NOUN
fnp-3806	1032	125	-	-	PUNCT
fnp-3806	1032	126	specific	specific	ADJ
fnp-3806	1032	127	2	2	NUM
fnp-3806	1032	128	-	-	PUNCT
fnp-3806	1032	129	like	like	ADJ
fnp-3806	1032	130	2	2	NUM
fnp-3806	1032	131	protein	protein	NOUN
fnp-3806	1032	132	(	(	PUNCT
fnp-3806	1032	133	g2l2	g2l2	PROPN
fnp-3806	1032	134	)	)	PUNCT
fnp-3806	1032	135	,	,	PUNCT
fnp-3806	1032	136	α	α	X
fnp-3806	1032	137	-	-	PUNCT
fnp-3806	1032	138	tubulin	tubulin	NOUN
fnp-3806	1032	139	and	and	CCONJ
fnp-3806	1032	140	β	β	NOUN
fnp-3806	1032	141	-	-	NOUN
fnp-3806	1032	142	actin	actin	NOUN
fnp-3806	1032	143	;	;	PUNCT
fnp-3806	1032	144	downregulation	downregulation	NOUN
fnp-3806	1032	145	and	and	CCONJ
fnp-3806	1032	146	dislocalization	dislocalization	NOUN
fnp-3806	1032	147	from	from	ADP
fnp-3806	1032	148	the	the	DET
fnp-3806	1032	149	nucleus	nucleus	NOUN
fnp-3806	1032	150	to	to	ADP
fnp-3806	1032	151	the	the	DET
fnp-3806	1032	152	cytoplasm	cytoplasm	NOUN
fnp-3806	1032	153	of	of	ADP
fnp-3806	1032	154	sfpq	sfpq	NOUN
fnp-3806	1032	155	,	,	PUNCT
fnp-3806	1032	156	their	their	PRON
fnp-3806	1032	157	colocalization	colocalization	NOUN
fnp-3806	1032	158	with	with	ADP
fnp-3806	1032	159	tia-1	tia-1	VERB
fnp-3806	1032	160	in	in	ADP
fnp-3806	1032	161	stress	stress	ADJ
fnp-3806	1032	162	granules	granule	NOUN
fnp-3806	1032	163	,	,	PUNCT
fnp-3806	1032	164	and	and	CCONJ
fnp-3806	1032	165	their	their	PRON
fnp-3806	1032	166	association	association	NOUN
fnp-3806	1032	167	with	with	ADP
fnp-3806	1032	168	tau	tau	PROPN
fnp-3806	1032	169	oligomers	oligomer	NOUN
fnp-3806	1032	170	resilient	resilient	ADJ
fnp-3806	1032	171	ad	ad	NOUN
fnp-3806	1032	172	variant	variant	NOUN
fnp-3806	1032	173	of	of	ADP
fnp-3806	1032	174	chromosome	chromosome	NOUN
fnp-3806	1032	175	18	18	NUM
fnp-3806	1032	176	upstream	upstream	NOUN
fnp-3806	1032	177	of	of	ADP
fnp-3806	1032	178	atp8b1	atp8b1	ADJ
fnp-3806	1032	179	;	;	PUNCT
fnp-3806	1032	180	rare	rare	ADJ
fnp-3806	1032	181	variant	variant	NOUN
fnp-3806	1032	182	in	in	ADP
fnp-3806	1032	183	the	the	DET
fnp-3806	1032	184	3'-utr	3'-utr	NOUN
fnp-3806	1032	185	of	of	ADP
fnp-3806	1032	186	rab10	rab10	NOUN
fnp-3806	1032	187	;	;	PUNCT
fnp-3806	1032	188	mef2c	mef2c	NOUN
fnp-3806	1032	189	upregulation	upregulation	NOUN
fnp-3806	1032	190	in	in	ADP
fnp-3806	1032	191	a	a	DET
fnp-3806	1032	192	subpopulation	subpopulation	NOUN
fnp-3806	1032	193	of	of	ADP
fnp-3806	1032	194	glutamatergic	glutamatergic	ADJ
fnp-3806	1032	195	neurons	neuron	NOUN
fnp-3806	1032	196	;	;	PUNCT
fnp-3806	1032	197	decreased	decrease	VERB
fnp-3806	1032	198	expression	expression	NOUN
fnp-3806	1032	199	levels	level	NOUN
fnp-3806	1032	200	of	of	ADP
fnp-3806	1032	201	chemokines	chemokine	NOUN
fnp-3806	1032	202	and	and	CCONJ
fnp-3806	1032	203	increased	increase	VERB
fnp-3806	1032	204	levels	level	NOUN
fnp-3806	1032	205	of	of	ADP
fnp-3806	1032	206	trophic	trophic	ADJ
fnp-3806	1032	207	factors	factor	NOUN
fnp-3806	1032	208	tangle	tangle	NOUN
fnp-3806	1032	209	-	-	PUNCT
fnp-3806	1032	210	predominant	predominant	ADJ
fnp-3806	1032	211	dementia	dementia	NOUN
fnp-3806	1032	212	association	association	NOUN
fnp-3806	1032	213	with	with	ADP
fnp-3806	1032	214	mapt	mapt	NOUN
fnp-3806	1032	215	h1	h1	NOUN
fnp-3806	1032	216	haplotype	haplotype	NOUN
fnp-3806	1032	217	table	table	NOUN
fnp-3806	1032	218	3	3	NUM
fnp-3806	1032	219	:	:	PUNCT
fnp-3806	1032	220	genetic	genetic	ADJ
fnp-3806	1032	221	and	and	CCONJ
fnp-3806	1032	222	molecular	molecular	ADJ
fnp-3806	1032	223	factors	factor	NOUN
fnp-3806	1032	224	linked	link	VERB
fnp-3806	1032	225	to	to	ADP
fnp-3806	1032	226	the	the	DET
fnp-3806	1032	227	ad	ad	NOUN
fnp-3806	1032	228	spectrum	spectrum	NOUN
fnp-3806	1032	229	(	(	PUNCT
fnp-3806	1032	230	see	see	VERB
fnp-3806	1032	231	sections	section	NOUN
fnp-3806	1032	232	3	3	NUM
fnp-3806	1032	233	,	,	PUNCT
fnp-3806	1032	234	4	4	NUM
fnp-3806	1032	235	and	and	CCONJ
fnp-3806	1032	236	21	21	NUM
fnp-3806	1032	237	for	for	ADP
fnp-3806	1032	238	references	reference	NOUN
fnp-3806	1032	239	)	)	PUNCT
fnp-3806	1032	240	.	.	PUNCT
fnp-3806	1033	1	considering	consider	VERB
fnp-3806	1033	2	the	the	DET
fnp-3806	1033	3	previous	previous	ADJ
fnp-3806	1033	4	data	datum	NOUN
fnp-3806	1033	5	,	,	PUNCT
fnp-3806	1033	6	and	and	CCONJ
fnp-3806	1033	7	the	the	DET
fnp-3806	1033	8	preponderance	preponderance	NOUN
fnp-3806	1033	9	of	of	ADP
fnp-3806	1033	10	tau	tau	PROPN
fnp-3806	1033	11	pathology	pathology	NOUN
fnp-3806	1033	12	over	over	ADP
fnp-3806	1033	13	β	β	NOUN
fnp-3806	1033	14	-	-	NOUN
fnp-3806	1033	15	amyloid	amyloid	ADJ
fnp-3806	1033	16	deposits	deposit	NOUN
fnp-3806	1033	17	at	at	ADP
fnp-3806	1033	18	the	the	DET
fnp-3806	1033	19	first	first	ADJ
fnp-3806	1033	20	and	and	CCONJ
fnp-3806	1033	21	middle	middle	ADJ
fnp-3806	1033	22	stages	stage	NOUN
fnp-3806	1033	23	of	of	ADP
fnp-3806	1033	24	ad	ad	NOUN
fnp-3806	1033	25	-	-	PUNCT
fnp-3806	1033	26	related	relate	VERB
fnp-3806	1033	27	pathology	pathology	NOUN
fnp-3806	1033	28	(	(	PUNCT
fnp-3806	1033	29	344	344	NUM
fnp-3806	1033	30	)	)	PUNCT
fnp-3806	1033	31	,	,	PUNCT
fnp-3806	1033	32	a	a	DET
fnp-3806	1033	33	modification	modification	NOUN
fnp-3806	1033	34	to	to	ADP
fnp-3806	1033	35	the	the	DET
fnp-3806	1033	36	nia	nia	PROPN
fnp-3806	1033	37	-	-	PUNCT
fnp-3806	1033	38	aa	aa	ADJ
fnp-3806	1033	39	“	"	PUNCT
fnp-3806	1033	40	abc	abc	PROPN
fnp-3806	1033	41	”	"	PUNCT
fnp-3806	1033	42	score	score	NOUN
fnp-3806	1033	43	level	level	NOUN
fnp-3806	1033	44	of	of	ADP
fnp-3806	1033	45	ad	ad	NOUN
fnp-3806	1033	46	neuropathologic	neuropathologic	NOUN
fnp-3806	1033	47	is	be	AUX
fnp-3806	1033	48	hereby	hereby	ADV
fnp-3806	1033	49	proposed	propose	VERB
fnp-3806	1033	50	.	.	PUNCT
fnp-3806	1034	1	the	the	DET
fnp-3806	1034	2	added	add	VERB
fnp-3806	1034	3	value	value	NOUN
fnp-3806	1034	4	is	be	AUX
fnp-3806	1034	5	the	the	DET
fnp-3806	1034	6	reflection	reflection	NOUN
fnp-3806	1034	7	of	of	ADP
fnp-3806	1034	8	tau	tau	PROPN
fnp-3806	1034	9	pathology	pathology	NOUN
fnp-3806	1034	10	at	at	ADP
fnp-3806	1034	11	the	the	DET
fnp-3806	1034	12	same	same	ADJ
fnp-3806	1034	13	diagnostic	diagnostic	ADJ
fnp-3806	1034	14	value	value	NOUN
fnp-3806	1034	15	as	as	ADP
fnp-3806	1034	16	β	β	NOUN
fnp-3806	1034	17	-	-	NOUN
fnp-3806	1034	18	amyloid	amyloid	NOUN
fnp-3806	1034	19	(	(	PUNCT
fnp-3806	1034	20	table	table	NOUN
fnp-3806	1034	21	4	4	NUM
fnp-3806	1034	22	)	)	PUNCT
fnp-3806	1034	23	.	.	PUNCT
fnp-3806	1035	1	ad	ad	NOUN
fnp-3806	1035	2	neuropathologic	neuropathologic	NOUN
fnp-3806	1035	3	change	change	VERB
fnp-3806	1035	4	a	a	DET
fnp-3806	1035	5	c	c	NOUN
fnp-3806	1035	6	b	b	NOUN
fnp-3806	1035	7	0	0	NUM
fnp-3806	1035	8	0	0	NUM
fnp-3806	1035	9	0	0	NUM
fnp-3806	1035	10	or	or	CCONJ
fnp-3806	1035	11	1	1	NUM
fnp-3806	1035	12	2	2	NUM
fnp-3806	1035	13	3	3	NUM
fnp-3806	1035	14	0	0	NUM
fnp-3806	1035	15	0	0	NUM
fnp-3806	1035	16	low	low	ADJ
fnp-3806	1035	17	low	low	ADJ
fnp-3806	1035	18	intermediate	intermediate	ADJ
fnp-3806	1035	19	1	1	NUM
fnp-3806	1035	20	0	0	NUM
fnp-3806	1035	21	or	or	CCONJ
fnp-3806	1035	22	1	1	NUM
fnp-3806	1035	23	low	low	ADJ
fnp-3806	1035	24	low	low	ADJ
fnp-3806	1035	25	intermediate	intermediate	ADJ
fnp-3806	1035	26	2	2	NUM
fnp-3806	1035	27	or	or	CCONJ
fnp-3806	1035	28	3	3	NUM
fnp-3806	1035	29	low	low	ADJ
fnp-3806	1035	30	intermediate	intermediate	ADJ
fnp-3806	1035	31	intermediate	intermediate	ADJ
fnp-3806	1035	32	2	2	NUM
fnp-3806	1035	33	any	any	DET
fnp-3806	1035	34	c	c	NOUN
fnp-3806	1035	35	low	low	ADJ
fnp-3806	1035	36	intermediate	intermediate	ADJ
fnp-3806	1035	37	intermediate	intermediate	ADJ
fnp-3806	1035	38	3	3	NUM
fnp-3806	1035	39	0	0	NUM
fnp-3806	1035	40	or	or	CCONJ
fnp-3806	1035	41	1	1	NUM
fnp-3806	1035	42	low	low	ADJ
fnp-3806	1035	43	intermediate	intermediate	ADJ
fnp-3806	1035	44	intermediate	intermediate	ADJ
fnp-3806	1035	45	2	2	NUM
fnp-3806	1035	46	or	or	CCONJ
fnp-3806	1035	47	3	3	NUM
fnp-3806	1035	48	low	low	ADJ
fnp-3806	1035	49	intermediate	intermediate	ADJ
fnp-3806	1035	50	high	high	ADJ
fnp-3806	1035	51	table	table	NOUN
fnp-3806	1035	52	4	4	NUM
fnp-3806	1035	53	:	:	PUNCT
fnp-3806	1035	54	modified	modify	VERB
fnp-3806	1035	55	“	"	PUNCT
fnp-3806	1035	56	abc	abc	PROPN
fnp-3806	1035	57	”	"	PUNCT
fnp-3806	1035	58	score	score	NOUN
fnp-3806	1035	59	level	level	NOUN
fnp-3806	1035	60	of	of	ADP
fnp-3806	1035	61	ad	ad	NOUN
fnp-3806	1035	62	neuropathologic	neuropathologic	NOUN
fnp-3806	1035	63	change	change	NOUN
fnp-3806	1035	64	.	.	PUNCT
fnp-3806	1036	1	aβ	aβ	X
fnp-3806	1036	2	/	/	SYM
fnp-3806	1036	3	amyloid	amyloid	NOUN
fnp-3806	1036	4	plaques	plaque	NOUN
fnp-3806	1036	5	(	(	PUNCT
fnp-3806	1036	6	a	a	X
fnp-3806	1036	7	)	)	PUNCT
fnp-3806	1036	8	,	,	PUNCT
fnp-3806	1036	9	nft	nft	PROPN
fnp-3806	1036	10	stage	stage	NOUN
fnp-3806	1036	11	(	(	PUNCT
fnp-3806	1036	12	b	b	NOUN
fnp-3806	1036	13	)	)	PUNCT
fnp-3806	1036	14	,	,	PUNCT
fnp-3806	1036	15	and	and	CCONJ
fnp-3806	1036	16	neuritic	neuritic	ADJ
fnp-3806	1036	17	plaque	plaque	NOUN
fnp-3806	1036	18	score	score	NOUN
fnp-3806	1036	19	(	(	PUNCT
fnp-3806	1036	20	c	c	NOUN
fnp-3806	1036	21	)	)	PUNCT
fnp-3806	1036	22	.	.	PUNCT
fnp-3806	1037	1	the	the	DET
fnp-3806	1037	2	combination	combination	NOUN
fnp-3806	1037	3	of	of	ADP
fnp-3806	1037	4	a	a	DET
fnp-3806	1037	5	,	,	PUNCT
fnp-3806	1037	6	b	b	NOUN
fnp-3806	1037	7	,	,	PUNCT
fnp-3806	1037	8	and	and	CCONJ
fnp-3806	1037	9	c	c	NOUN
fnp-3806	1037	10	scores	score	NOUN
fnp-3806	1037	11	is	be	AUX
fnp-3806	1037	12	designated	designate	VERB
fnp-3806	1037	13	as	as	ADP
fnp-3806	1037	14	“	"	PUNCT
fnp-3806	1037	15	not	not	PART
fnp-3806	1037	16	”	"	PUNCT
fnp-3806	1037	17	,	,	PUNCT
fnp-3806	1037	18	“	"	PUNCT
fnp-3806	1037	19	low	low	ADJ
fnp-3806	1037	20	”	"	PUNCT
fnp-3806	1037	21	,	,	PUNCT
fnp-3806	1037	22	“	"	PUNCT
fnp-3806	1037	23	intermediate	intermediate	ADJ
fnp-3806	1037	24	”	"	PUNCT
fnp-3806	1037	25	or	or	CCONJ
fnp-3806	1037	26	“	"	PUNCT
fnp-3806	1037	27	high	high	ADJ
fnp-3806	1037	28	”	"	PUNCT
fnp-3806	1037	29	ad	ad	NOUN
fnp-3806	1037	30	neuropathologic	neuropathologic	NOUN
fnp-3806	1037	31	change	change	NOUN
fnp-3806	1037	32	.	.	PUNCT
fnp-3806	1038	1	“	"	PUNCT
fnp-3806	1038	2	intermediate	intermediate	ADJ
fnp-3806	1038	3	”	"	PUNCT
fnp-3806	1038	4	or	or	CCONJ
fnp-3806	1038	5	“	"	PUNCT
fnp-3806	1038	6	high	high	ADJ
fnp-3806	1038	7	”	"	PUNCT
fnp-3806	1038	8	ad	ad	NOUN
fnp-3806	1038	9	neuropathologic	neuropathologic	NOUN
fnp-3806	1038	10	change	change	NOUN
fnp-3806	1038	11	is	be	AUX
fnp-3806	1038	12	considered	consider	VERB
fnp-3806	1038	13	sufficient	sufficient	ADJ
fnp-3806	1038	14	for	for	ADP
fnp-3806	1038	15	dementia	dementia	NOUN
fnp-3806	1038	16	.	.	PUNCT
fnp-3806	1039	1	here	here	ADV
fnp-3806	1039	2	,	,	PUNCT
fnp-3806	1039	3	nfts	nft	NOUN
fnp-3806	1039	4	are	be	AUX
fnp-3806	1039	5	considered	consider	VERB
fnp-3806	1039	6	with	with	ADP
fnp-3806	1039	7	equal	equal	ADJ
fnp-3806	1039	8	relevance	relevance	NOUN
fnp-3806	1039	9	to	to	ADP
fnp-3806	1039	10	sps	sps	PROPN
fnp-3806	1039	11	in	in	ADP
fnp-3806	1039	12	the	the	DET
fnp-3806	1039	13	progression	progression	NOUN
fnp-3806	1039	14	from	from	ADP
fnp-3806	1039	15	normal	normal	ADJ
fnp-3806	1039	16	brain	brain	NOUN
fnp-3806	1039	17	aging	aging	NOUN
fnp-3806	1039	18	with	with	ADP
fnp-3806	1039	19	nft	nft	PROPN
fnp-3806	1039	20	changes	change	NOUN
fnp-3806	1039	21	,	,	PUNCT
fnp-3806	1039	22	part	part	NOUN
fnp-3806	1039	23	,	,	PUNCT
fnp-3806	1039	24	preclinical	preclinical	ADJ
fnp-3806	1039	25	ad	ad	NOUN
fnp-3806	1039	26	,	,	PUNCT
fnp-3806	1039	27	and	and	CCONJ
fnp-3806	1039	28	sad	sad	ADJ
fnp-3806	1039	29	(	(	PUNCT
fnp-3806	1039	30	including	include	VERB
fnp-3806	1039	31	ad	ad	NOUN
fnp-3806	1039	32	variants	variant	NOUN
fnp-3806	1039	33	,	,	PUNCT
fnp-3806	1039	34	rpad	rpad	NOUN
fnp-3806	1039	35	and	and	CCONJ
fnp-3806	1039	36	adnc	adnc	ADJ
fnp-3806	1039	37	in	in	ADP
fnp-3806	1039	38	centenarians	centenarian	NOUN
fnp-3806	1039	39	)	)	PUNCT
fnp-3806	1039	40	.	.	PUNCT
fnp-3806	1040	1	22	22	NUM
fnp-3806	1040	2	.	.	PUNCT
fnp-3806	1041	1	biochemical	biochemical	ADJ
fnp-3806	1041	2	changes	change	NOUN
fnp-3806	1041	3	beyond	beyond	ADP
fnp-3806	1041	4	tau	tau	PROPN
fnp-3806	1041	5	and	and	CCONJ
fnp-3806	1041	6	β	β	NOUN
fnp-3806	1041	7	-	-	NOUN
fnp-3806	1041	8	amyloid	amyloid	NOUN
fnp-3806	1041	9	at	at	ADP
fnp-3806	1041	10	the	the	DET
fnp-3806	1041	11	the	the	DET
fnp-3806	1041	12	first	first	ADJ
fnp-3806	1041	13	stages	stage	NOUN
fnp-3806	1041	14	of	of	ADP
fnp-3806	1041	15	nft	nft	PROPN
fnp-3806	1041	16	pathology	pathology	NOUN
fnp-3806	1041	17	in	in	ADP
fnp-3806	1041	18	addition	addition	NOUN
fnp-3806	1041	19	to	to	ADP
fnp-3806	1041	20	the	the	DET
fnp-3806	1041	21	classical	classical	ADJ
fnp-3806	1041	22	neuropathological	neuropathological	ADJ
fnp-3806	1041	23	hallmarks	hallmark	NOUN
fnp-3806	1041	24	restricted	restrict	VERB
fnp-3806	1041	25	to	to	ADP
fnp-3806	1041	26	the	the	DET
fnp-3806	1041	27	inner	inner	ADJ
fnp-3806	1041	28	region	region	NOUN
fnp-3806	1041	29	of	of	ADP
fnp-3806	1041	30	the	the	DET
fnp-3806	1041	31	temporal	temporal	ADJ
fnp-3806	1041	32	lobe	lobe	NOUN
fnp-3806	1041	33	and	and	CCONJ
fnp-3806	1041	34	selected	select	VERB
fnp-3806	1041	35	nuclei	nucleus	NOUN
fnp-3806	1041	36	of	of	ADP
fnp-3806	1041	37	the	the	DET
fnp-3806	1041	38	brain	brain	NOUN
fnp-3806	1041	39	stem	stem	NOUN
fnp-3806	1041	40	which	which	PRON
fnp-3806	1041	41	characterize	characterize	VERB
fnp-3806	1041	42	the	the	DET
fnp-3806	1041	43	first	first	ADJ
fnp-3806	1041	44	stages	stage	NOUN
fnp-3806	1041	45	of	of	ADP
fnp-3806	1041	46	nft	nft	PROPN
fnp-3806	1041	47	pathology	pathology	PROPN
fnp-3806	1041	48	,	,	PUNCT
fnp-3806	1041	49	there	there	PRON
fnp-3806	1041	50	is	be	VERB
fnp-3806	1041	51	cumulative	cumulative	ADJ
fnp-3806	1041	52	evidence	evidence	NOUN
fnp-3806	1041	53	of	of	ADP
fnp-3806	1041	54	molecular	molecular	ADJ
fnp-3806	1041	55	and	and	CCONJ
fnp-3806	1041	56	biochemical	biochemical	ADJ
fnp-3806	1041	57	alterations	alteration	NOUN
fnp-3806	1041	58	in	in	ADP
fnp-3806	1041	59	other	other	ADJ
fnp-3806	1041	60	regions	region	NOUN
fnp-3806	1041	61	in	in	ADP
fnp-3806	1041	62	the	the	DET
fnp-3806	1041	63	same	same	ADJ
fnp-3806	1041	64	brains	brain	NOUN
fnp-3806	1041	65	.	.	PUNCT
fnp-3806	1042	1	several	several	ADJ
fnp-3806	1042	2	brain	brain	NOUN
fnp-3806	1042	3	regions	region	NOUN
fnp-3806	1042	4	such	such	ADJ
fnp-3806	1042	5	as	as	ADP
fnp-3806	1042	6	the	the	DET
fnp-3806	1042	7	frontal	frontal	ADJ
fnp-3806	1042	8	cortex	cortex	NOUN
fnp-3806	1042	9	,	,	PUNCT
fnp-3806	1042	10	which	which	PRON
fnp-3806	1042	11	does	do	AUX
fnp-3806	1042	12	not	not	PART
fnp-3806	1042	13	show	show	VERB
fnp-3806	1042	14	nft	nft	PROPN
fnp-3806	1042	15	pathology	pathology	PROPN
fnp-3806	1042	16	at	at	ADP
fnp-3806	1042	17	stages	stage	NOUN
fnp-3806	1042	18	i	i	PROPN
fnp-3806	1042	19	-	-	PUNCT
fnp-3806	1042	20	iii	iii	PROPN
fnp-3806	1042	21	(	(	PUNCT
fnp-3806	1042	22	and	and	CCONJ
fnp-3806	1042	23	very	very	ADV
fnp-3806	1042	24	rarely	rarely	ADV
fnp-3806	1042	25	,	,	PUNCT
fnp-3806	1042	26	if	if	SCONJ
fnp-3806	1042	27	present	present	ADJ
fnp-3806	1042	28	,	,	PUNCT
fnp-3806	1042	29	β	β	NOUN
fnp-3806	1042	30	-	-	NOUN
fnp-3806	1042	31	amyloid	amyloid	ADJ
fnp-3806	1042	32	deposition	deposition	NOUN
fnp-3806	1042	33	at	at	ADP
fnp-3806	1042	34	these	these	DET
fnp-3806	1042	35	stages	stage	NOUN
fnp-3806	1042	36	)	)	PUNCT
fnp-3806	1042	37	,	,	PUNCT
fnp-3806	1042	38	show	show	VERB
fnp-3806	1042	39	altered	alter	VERB
fnp-3806	1042	40	lipid	lipid	NOUN
fnp-3806	1042	41	and	and	CCONJ
fnp-3806	1042	42	protein	protein	NOUN
fnp-3806	1042	43	membrane	membrane	NOUN
fnp-3806	1042	44	composition	composition	NOUN
fnp-3806	1042	45	,	,	PUNCT
fnp-3806	1042	46	abnormal	abnormal	ADJ
fnp-3806	1042	47	mitochondrial	mitochondrial	ADJ
fnp-3806	1042	48	function	function	NOUN
fnp-3806	1042	49	,	,	PUNCT
fnp-3806	1042	50	oxidative	oxidative	ADJ
fnp-3806	1042	51	stress	stress	NOUN
fnp-3806	1042	52	damage	damage	NOUN
fnp-3806	1042	53	,	,	PUNCT
fnp-3806	1042	54	altered	alter	VERB
fnp-3806	1042	55	protein	protein	NOUN
fnp-3806	1042	56	synthesis	synthesis	NOUN
fnp-3806	1042	57	,	,	PUNCT
fnp-3806	1042	58	activation	activation	NOUN
fnp-3806	1042	59	of	of	ADP
fnp-3806	1042	60	kinases	kinase	NOUN
fnp-3806	1042	61	,	,	PUNCT
fnp-3806	1042	62	dysregulated	dysregulated	ADJ
fnp-3806	1042	63	protein	protein	NOUN
fnp-3806	1042	64	phosphorylation	phosphorylation	NOUN
fnp-3806	1042	65	,	,	PUNCT
fnp-3806	1042	66	and	and	CCONJ
fnp-3806	1042	67	abnormal	abnormal	ADJ
fnp-3806	1042	68	inflammatory	inflammatory	ADJ
fnp-3806	1042	69	responses	response	NOUN
fnp-3806	1042	70	,	,	PUNCT
fnp-3806	1042	71	among	among	ADP
fnp-3806	1042	72	other	other	ADJ
fnp-3806	1042	73	disruptions	disruption	NOUN
fnp-3806	1042	74	.	.	PUNCT
fnp-3806	1043	1	all	all	PRON
fnp-3806	1043	2	of	of	ADP
fnp-3806	1043	3	these	these	DET
fnp-3806	1043	4	alterations	alteration	NOUN
fnp-3806	1043	5	advance	advance	VERB
fnp-3806	1043	6	in	in	ADP
fnp-3806	1043	7	parallel	parallel	NOUN
fnp-3806	1043	8	with	with	ADP
fnp-3806	1043	9	the	the	DET
fnp-3806	1043	10	progression	progression	NOUN
fnp-3806	1043	11	of	of	ADP
fnp-3806	1043	12	nft	nft	PROPN
fnp-3806	1043	13	pathology	pathology	PROPN
fnp-3806	1043	14	;	;	PUNCT
fnp-3806	1043	15	most	most	ADJ
fnp-3806	1043	16	of	of	ADP
fnp-3806	1043	17	them	they	PRON
fnp-3806	1043	18	have	have	VERB
fnp-3806	1043	19	implications	implication	NOUN
fnp-3806	1043	20	in	in	ADP
fnp-3806	1043	21	tau	tau	PROPN
fnp-3806	1043	22	and	and	CCONJ
fnp-3806	1043	23	β	β	NOUN
fnp-3806	1043	24	-	-	ADJ
fnp-3806	1043	25	amyloid	amyloid	ADJ
fnp-3806	1043	26	pathology	pathology	NOUN
fnp-3806	1043	27	,	,	PUNCT
fnp-3806	1043	28	and	and	CCONJ
fnp-3806	1043	29	they	they	PRON
fnp-3806	1043	30	all	all	PRON
fnp-3806	1043	31	persist	persist	VERB
fnp-3806	1043	32	or	or	CCONJ
fnp-3806	1043	33	increase	increase	VERB
fnp-3806	1043	34	at	at	ADP
fnp-3806	1043	35	middle	middle	ADJ
fnp-3806	1043	36	and	and	CCONJ
fnp-3806	1043	37	advanced	advanced	ADJ
fnp-3806	1043	38	nft	nft	PROPN
fnp-3806	1043	39	stages	stage	NOUN
fnp-3806	1043	40	and	and	CCONJ
fnp-3806	1043	41	sad	sad	ADJ
fnp-3806	1043	42	.	.	PUNCT
fnp-3806	1044	1	the	the	DET
fnp-3806	1044	2	terms	term	NOUN
fnp-3806	1044	3	nft	nft	PROPN
fnp-3806	1044	4	and	and	CCONJ
fnp-3806	1044	5	sad	sad	ADJ
fnp-3806	1044	6	in	in	ADP
fnp-3806	1044	7	these	these	DET
fnp-3806	1044	8	sections	section	NOUN
fnp-3806	1044	9	are	be	AUX
fnp-3806	1044	10	those	those	PRON
fnp-3806	1044	11	used	use	VERB
fnp-3806	1044	12	in	in	ADP
fnp-3806	1044	13	the	the	DET
fnp-3806	1044	14	original	original	ADJ
fnp-3806	1044	15	publications	publication	NOUN
fnp-3806	1044	16	.	.	PUNCT
fnp-3806	1044	17	22a	22a	NOUN
fnp-3806	1044	18	.	.	PUNCT
fnp-3806	1045	1	aberrant	aberrant	ADJ
fnp-3806	1045	2	cell	cell	NOUN
fnp-3806	1045	3	-	-	PUNCT
fnp-3806	1045	4	cycle	cycle	NOUN
fnp-3806	1045	5	re	re	NOUN
fnp-3806	1045	6	-	-	NOUN
fnp-3806	1045	7	entry	entry	NOUN
fnp-3806	1045	8	,	,	PUNCT
fnp-3806	1045	9	and	and	CCONJ
fnp-3806	1045	10	altered	alter	VERB
fnp-3806	1045	11	adult	adult	NOUN
fnp-3806	1045	12	neurogenesis	neurogenesis	NOUN
fnp-3806	1045	13	the	the	DET
fnp-3806	1045	14	nervous	nervous	ADJ
fnp-3806	1045	15	system	system	NOUN
fnp-3806	1045	16	has	have	VERB
fnp-3806	1045	17	plastic	plastic	ADJ
fnp-3806	1045	18	capacities	capacity	NOUN
fnp-3806	1045	19	and	and	CCONJ
fnp-3806	1045	20	this	this	PRON
fnp-3806	1045	21	is	be	AUX
fnp-3806	1045	22	manifested	manifest	VERB
fnp-3806	1045	23	in	in	ADP
fnp-3806	1045	24	many	many	ADJ
fnp-3806	1045	25	ways	way	NOUN
fnp-3806	1045	26	in	in	ADP
fnp-3806	1045	27	sad	sad	ADJ
fnp-3806	1045	28	.	.	PUNCT
fnp-3806	1046	1	one	one	NUM
fnp-3806	1046	2	of	of	ADP
fnp-3806	1046	3	these	these	PRON
fnp-3806	1046	4	is	be	AUX
fnp-3806	1046	5	the	the	DET
fnp-3806	1046	6	activation	activation	NOUN
fnp-3806	1046	7	of	of	ADP
fnp-3806	1046	8	pathways	pathway	NOUN
fnp-3806	1046	9	geared	gear	VERB
fnp-3806	1046	10	to	to	PART
fnp-3806	1046	11	activate	activate	VERB
fnp-3806	1046	12	cell	cell	NOUN
fnp-3806	1046	13	cycle	cycle	NOUN
fnp-3806	1046	14	re	re	NOUN
fnp-3806	1046	15	-	-	NOUN
fnp-3806	1046	16	entry	entry	NOUN
fnp-3806	1046	17	.	.	PUNCT
fnp-3806	1047	1	however	however	ADV
fnp-3806	1047	2	,	,	PUNCT
fnp-3806	1047	3	neurons	neuron	NOUN
fnp-3806	1047	4	are	be	AUX
fnp-3806	1047	5	post	post	ADJ
fnp-3806	1047	6	-	-	ADJ
fnp-3806	1047	7	mitotic	mitotic	ADJ
fnp-3806	1047	8	cells	cell	NOUN
fnp-3806	1047	9	that	that	PRON
fnp-3806	1047	10	activate	activate	VERB
fnp-3806	1047	11	cell	cell	NOUN
fnp-3806	1047	12	death	death	NOUN
fnp-3806	1047	13	programs	program	NOUN
fnp-3806	1047	14	at	at	ADP
fnp-3806	1047	15	g1	g1	PROPN
fnp-3806	1047	16	/	/	SYM
fnp-3806	1047	17	a	a	DET
fnp-3806	1047	18	and	and	CCONJ
fnp-3806	1047	19	g2	g2	PROPN
fnp-3806	1047	20	/	/	SYM
fnp-3806	1047	21	m	m	PROPN
fnp-3806	1047	22	points	point	NOUN
fnp-3806	1047	23	in	in	ADP
fnp-3806	1047	24	response	response	NOUN
fnp-3806	1047	25	to	to	ADP
fnp-3806	1047	26	cell	cell	NOUN
fnp-3806	1047	27	cycle	cycle	NOUN
fnp-3806	1047	28	reactivation	reactivation	NOUN
fnp-3806	1047	29	(	(	PUNCT
fnp-3806	1047	30	1328	1328	NUM
fnp-3806	1047	31	)	)	PUNCT
fnp-3806	1047	32	.	.	PUNCT
fnp-3806	1048	1	aberrant	aberrant	ADJ
fnp-3806	1048	2	neuronal	neuronal	ADJ
fnp-3806	1048	3	cell	cell	NOUN
fnp-3806	1048	4	-	-	PUNCT
fnp-3806	1048	5	cycle	cycle	NOUN
fnp-3806	1048	6	re	re	NOUN
fnp-3806	1048	7	-	-	NOUN
fnp-3806	1048	8	entry	entry	NOUN
fnp-3806	1048	9	,	,	PUNCT
fnp-3806	1048	10	as	as	SCONJ
fnp-3806	1048	11	revealed	reveal	VERB
fnp-3806	1048	12	by	by	ADP
fnp-3806	1048	13	the	the	DET
fnp-3806	1048	14	expression	expression	NOUN
fnp-3806	1048	15	of	of	ADP
fnp-3806	1048	16	various	various	ADJ
fnp-3806	1048	17	proteins	protein	NOUN
fnp-3806	1048	18	involved	involve	VERB
fnp-3806	1048	19	in	in	ADP
fnp-3806	1048	20	the	the	DET
fnp-3806	1048	21	activation	activation	NOUN
fnp-3806	1048	22	and	and	CCONJ
fnp-3806	1048	23	progression	progression	NOUN
fnp-3806	1048	24	of	of	ADP
fnp-3806	1048	25	the	the	DET
fnp-3806	1048	26	cell	cell	NOUN
fnp-3806	1048	27	cycle	cycle	NOUN
fnp-3806	1048	28	,	,	PUNCT
fnp-3806	1048	29	is	be	AUX
fnp-3806	1048	30	produced	produce	VERB
fnp-3806	1048	31	in	in	ADP
fnp-3806	1048	32	a	a	DET
fnp-3806	1048	33	subpopulation	subpopulation	NOUN
fnp-3806	1048	34	of	of	ADP
fnp-3806	1048	35	neurons	neuron	NOUN
fnp-3806	1048	36	in	in	ADP
fnp-3806	1048	37	sad	sad	ADJ
fnp-3806	1048	38	(	(	PUNCT
fnp-3806	1048	39	1329	1329	NUM
fnp-3806	1048	40	-	-	SYM
fnp-3806	1048	41	1340	1340	NUM
fnp-3806	1048	42	)	)	PUNCT
fnp-3806	1048	43	.	.	PUNCT
fnp-3806	1049	1	the	the	DET
fnp-3806	1049	2	expression	expression	NOUN
fnp-3806	1049	3	of	of	ADP
fnp-3806	1049	4	cell	cell	NOUN
fnp-3806	1049	5	-	-	PUNCT
fnp-3806	1049	6	cycle	cycle	NOUN
fnp-3806	1049	7	-	-	PUNCT
fnp-3806	1049	8	related	relate	VERB
fnp-3806	1049	9	proteins	protein	NOUN
fnp-3806	1049	10	occurs	occur	VERB
fnp-3806	1049	11	before	before	ADP
fnp-3806	1049	12	the	the	DET
fnp-3806	1049	13	appearance	appearance	NOUN
fnp-3806	1049	14	of	of	ADP
fnp-3806	1049	15	nfts	nft	NOUN
fnp-3806	1049	16	and	and	CCONJ
fnp-3806	1049	17	sps	sps	PROPN
fnp-3806	1049	18	and	and	CCONJ
fnp-3806	1049	19	may	may	AUX
fnp-3806	1049	20	trigger	trigger	VERB
fnp-3806	1049	21	programmed	program	VERB
fnp-3806	1049	22	cell	cell	NOUN
fnp-3806	1049	23	death	death	NOUN
fnp-3806	1049	24	or	or	CCONJ
fnp-3806	1049	25	the	the	DET
fnp-3806	1049	26	activation	activation	NOUN
fnp-3806	1049	27	of	of	ADP
fnp-3806	1049	28	kinases	kinase	NOUN
fnp-3806	1049	29	leading	lead	VERB
fnp-3806	1049	30	to	to	ADP
fnp-3806	1049	31	oxidative	oxidative	ADJ
fnp-3806	1049	32	stress	stress	NOUN
fnp-3806	1049	33	damage	damage	NOUN
fnp-3806	1049	34	,	,	PUNCT
fnp-3806	1049	35	tau	tau	PROPN
fnp-3806	1049	36	hyperphosphorylation	hyperphosphorylation	NOUN
fnp-3806	1049	37	,	,	PUNCT
fnp-3806	1049	38	and	and	CCONJ
fnp-3806	1049	39	activation	activation	NOUN
fnp-3806	1049	40	of	of	ADP
fnp-3806	1049	41	β	β	NOUN
fnp-3806	1049	42	-	-	NOUN
fnp-3806	1049	43	amyloid	amyloid	ADJ
fnp-3806	1049	44	pathways	pathway	NOUN
fnp-3806	1049	45	(	(	PUNCT
fnp-3806	1049	46	1341	1341	NUM
fnp-3806	1049	47	-	-	SYM
fnp-3806	1049	48	1346	1346	NUM
fnp-3806	1049	49	)	)	PUNCT
fnp-3806	1049	50	.	.	PUNCT
fnp-3806	1050	1	the	the	DET
fnp-3806	1050	2	expression	expression	NOUN
fnp-3806	1050	3	of	of	ADP
fnp-3806	1050	4	p75ntr	p75ntr	NOUN
fnp-3806	1050	5	in	in	ADP
fnp-3806	1050	6	doublecortin	doublecortin	NOUN
fnp-3806	1050	7	(	(	PUNCT
fnp-3806	1050	8	dcx)-immunoreactive	dcx)-immunoreactive	ADJ
fnp-3806	1050	9	dentate	dentate	ADJ
fnp-3806	1050	10	gyrus	gyrus	NOUN
fnp-3806	1050	11	progenitors	progenitor	NOUN
fnp-3806	1050	12	is	be	AUX
fnp-3806	1050	13	reduced	reduce	VERB
fnp-3806	1050	14	in	in	ADP
fnp-3806	1050	15	ad	ad	NOUN
fnp-3806	1050	16	and	and	CCONJ
fnp-3806	1050	17	related	relate	VERB
fnp-3806	1050	18	transgenic	transgenic	NOUN
fnp-3806	1050	19	models	model	NOUN
fnp-3806	1050	20	.	.	PUNCT
fnp-3806	1051	1	the	the	DET
fnp-3806	1051	2	inoculation	inoculation	NOUN
fnp-3806	1051	3	of	of	ADP
fnp-3806	1051	4	pro	pro	ADJ
fnp-3806	1051	5	-	-	ADJ
fnp-3806	1051	6	ngf	ngf	ADJ
fnp-3806	1051	7	neutralizing	neutralizing	ADJ
fnp-3806	1051	8	antibodies	antibody	NOUN
fnp-3806	1051	9	into	into	ADP
fnp-3806	1051	10	the	the	DET
fnp-3806	1051	11	dentate	dentate	ADJ
fnp-3806	1051	12	gyrus	gyrus	NOUN
fnp-3806	1051	13	restores	restore	VERB
fnp-3806	1051	14	memory	memory	NOUN
fnp-3806	1051	15	performance	performance	NOUN
fnp-3806	1051	16	of	of	ADP
fnp-3806	1051	17	app	app	ADJ
fnp-3806	1051	18	/	/	SYM
fnp-3806	1051	19	ps1	ps1	NOUN
fnp-3806	1051	20	animals	animal	NOUN
fnp-3806	1051	21	and	and	CCONJ
fnp-3806	1051	22	significantly	significantly	ADV
fnp-3806	1051	23	increases	increase	VERB
fnp-3806	1051	24	the	the	DET
fnp-3806	1051	25	percentage	percentage	NOUN
fnp-3806	1051	26	of	of	ADP
fnp-3806	1051	27	dcx+	dcx+	ADJ
fnp-3806	1051	28	progenitors	progenitor	NOUN
fnp-3806	1051	29	in	in	ADP
fnp-3806	1051	30	the	the	DET
fnp-3806	1051	31	dentate	dentate	ADJ
fnp-3806	1051	32	gyrus	gyrus	NOUN
fnp-3806	1051	33	of	of	ADP
fnp-3806	1051	34	these	these	DET
fnp-3806	1051	35	animals	animal	NOUN
fnp-3806	1051	36	,	,	PUNCT
fnp-3806	1051	37	thus	thus	ADV
fnp-3806	1051	38	suggesting	suggest	VERB
fnp-3806	1051	39	that	that	SCONJ
fnp-3806	1051	40	impaired	impaired	ADJ
fnp-3806	1051	41	prongf	prongf	NOUN
fnp-3806	1051	42	-	-	PUNCT
fnp-3806	1051	43	p75ntr	p75ntr	NOUN
fnp-3806	1051	44	signaling	signal	VERB
fnp-3806	1051	45	blocks	block	NOUN
fnp-3806	1051	46	adult	adult	NOUN
fnp-3806	1051	47	neurogenesis	neurogenesis	NOUN
fnp-3806	1051	48	in	in	ADP
fnp-3806	1051	49	ad	ad	NOUN
fnp-3806	1051	50	(	(	PUNCT
fnp-3806	1051	51	1347	1347	NUM
fnp-3806	1051	52	)	)	PUNCT
fnp-3806	1051	53	.	.	PUNCT
fnp-3806	1052	1	moreover	moreover	ADV
fnp-3806	1052	2	,	,	PUNCT
fnp-3806	1052	3	the	the	DET
fnp-3806	1052	4	prongf	prongf	NOUN
fnp-3806	1052	5	/	/	SYM
fnp-3806	1052	6	p75ntr	p75ntr	NOUN
fnp-3806	1052	7	signaling	signal	VERB
fnp-3806	1052	8	pathway	pathway	NOUN
fnp-3806	1052	9	blocks	block	NOUN
fnp-3806	1052	10	adult	adult	NOUN
fnp-3806	1052	11	neurogenesis	neurogenesis	NOUN
fnp-3806	1052	12	and	and	CCONJ
fnp-3806	1052	13	neuron	neuron	NOUN
fnp-3806	1052	14	cell	cell	NOUN
fnp-3806	1052	15	death	death	NOUN
fnp-3806	1052	16	in	in	ADP
fnp-3806	1052	17	ad	ad	NOUN
fnp-3806	1052	18	(	(	PUNCT
fnp-3806	1052	19	670	670	NUM
fnp-3806	1052	20	-	-	SYM
fnp-3806	1052	21	672	672	NUM
fnp-3806	1052	22	)	)	PUNCT
fnp-3806	1052	23	.	.	PUNCT
fnp-3806	1053	1	altered	alter	VERB
fnp-3806	1053	2	adult	adult	NOUN
fnp-3806	1053	3	neurogenesis	neurogenesis	NOUN
fnp-3806	1053	4	is	be	AUX
fnp-3806	1053	5	not	not	PART
fnp-3806	1053	6	restricted	restrict	VERB
fnp-3806	1053	7	to	to	PART
fnp-3806	1053	8	sad	sad	ADJ
fnp-3806	1053	9	,	,	PUNCT
fnp-3806	1053	10	as	as	SCONJ
fnp-3806	1053	11	it	it	PRON
fnp-3806	1053	12	occurs	occur	VERB
fnp-3806	1053	13	as	as	ADV
fnp-3806	1053	14	well	well	ADV
fnp-3806	1053	15	in	in	ADP
fnp-3806	1053	16	the	the	DET
fnp-3806	1053	17	dentate	dentate	ADJ
fnp-3806	1053	18	gyrus	gyrus	NOUN
fnp-3806	1053	19	in	in	ADP
fnp-3806	1053	20	other	other	ADJ
fnp-3806	1053	21	neurodegenerative	neurodegenerative	ADJ
fnp-3806	1053	22	diseases	disease	NOUN
fnp-3806	1053	23	such	such	ADJ
fnp-3806	1053	24	as	as	ADP
fnp-3806	1053	25	huntington	huntington	PROPN
fnp-3806	1053	26	’s	’s	PART
fnp-3806	1053	27	disease	disease	NOUN
fnp-3806	1053	28	,	,	PUNCT
fnp-3806	1053	29	amyotrophic	amyotrophic	ADJ
fnp-3806	1053	30	lateral	lateral	ADJ
fnp-3806	1053	31	sclerosis	sclerosis	NOUN
fnp-3806	1053	32	,	,	PUNCT
fnp-3806	1053	33	lewy	lewy	PROPN
fnp-3806	1053	34	body	body	NOUN
fnp-3806	1053	35	disease	disease	NOUN
fnp-3806	1053	36	,	,	PUNCT
fnp-3806	1053	37	and	and	CCONJ
fnp-3806	1053	38	frontotemporal	frontotemporal	ADJ
fnp-3806	1053	39	dementia	dementia	NOUN
fnp-3806	1053	40	(	(	PUNCT
fnp-3806	1053	41	1348	1348	NUM
fnp-3806	1053	42	)	)	PUNCT
fnp-3806	1053	43	.	.	PUNCT
fnp-3806	1054	1	22b	22b	NUM
fnp-3806	1054	2	.	.	PUNCT
fnp-3806	1055	1	brain	brain	NOUN
fnp-3806	1055	2	lipids	lipids	ADP
fnp-3806	1055	3	the	the	DET
fnp-3806	1055	4	brain	brain	NOUN
fnp-3806	1055	5	is	be	AUX
fnp-3806	1055	6	the	the	DET
fnp-3806	1055	7	second	second	ADJ
fnp-3806	1055	8	richest	rich	ADJ
fnp-3806	1055	9	organ	organ	NOUN
fnp-3806	1055	10	in	in	ADP
fnp-3806	1055	11	lipids	lipid	NOUN
fnp-3806	1055	12	after	after	ADP
fnp-3806	1055	13	the	the	DET
fnp-3806	1055	14	adipose	adipose	ADJ
fnp-3806	1055	15	tissue	tissue	NOUN
fnp-3806	1055	16	.	.	PUNCT
fnp-3806	1056	1	cholesterol	cholesterol	NOUN
fnp-3806	1056	2	accounts	account	VERB
fnp-3806	1056	3	for	for	ADP
fnp-3806	1056	4	20	20	NUM
fnp-3806	1056	5	-	-	SYM
fnp-3806	1056	6	25	25	NUM
fnp-3806	1056	7	%	%	NOUN
fnp-3806	1056	8	of	of	ADP
fnp-3806	1056	9	the	the	DET
fnp-3806	1056	10	total	total	ADJ
fnp-3806	1056	11	lipids	lipid	NOUN
fnp-3806	1056	12	in	in	ADP
fnp-3806	1056	13	the	the	DET
fnp-3806	1056	14	plasma	plasma	NOUN
fnp-3806	1056	15	membrane	membrane	NOUN
fnp-3806	1056	16	of	of	ADP
fnp-3806	1056	17	neurons	neuron	NOUN
fnp-3806	1056	18	;	;	PUNCT
fnp-3806	1056	19	most	most	ADJ
fnp-3806	1056	20	local	local	ADJ
fnp-3806	1056	21	cholesterol	cholesterol	NOUN
fnp-3806	1056	22	is	be	AUX
fnp-3806	1056	23	synthesized	synthesize	VERB
fnp-3806	1056	24	by	by	ADP
fnp-3806	1056	25	astrocytes	astrocyte	NOUN
fnp-3806	1056	26	in	in	ADP
fnp-3806	1056	27	the	the	DET
fnp-3806	1056	28	adult	adult	NOUN
fnp-3806	1056	29	brain	brain	NOUN
fnp-3806	1056	30	(	(	PUNCT
fnp-3806	1056	31	1349	1349	NUM
fnp-3806	1056	32	)	)	PUNCT
fnp-3806	1056	33	.	.	PUNCT
fnp-3806	1057	1	glycerophospholipids	glycerophospholipid	NOUN
fnp-3806	1057	2	are	be	AUX
fnp-3806	1057	3	the	the	DET
fnp-3806	1057	4	main	main	ADJ
fnp-3806	1057	5	phospholipid	phospholipid	NOUN
fnp-3806	1057	6	components	component	NOUN
fnp-3806	1057	7	ubiquitously	ubiquitously	ADV
fnp-3806	1057	8	found	find	VERB
fnp-3806	1057	9	in	in	ADP
fnp-3806	1057	10	cell	cell	NOUN
fnp-3806	1057	11	membranes	membrane	NOUN
fnp-3806	1057	12	,	,	PUNCT
fnp-3806	1057	13	and	and	CCONJ
fnp-3806	1057	14	they	they	PRON
fnp-3806	1057	15	are	be	AUX
fnp-3806	1057	16	found	find	VERB
fnp-3806	1057	17	in	in	ADP
fnp-3806	1057	18	abundance	abundance	NOUN
fnp-3806	1057	19	in	in	ADP
fnp-3806	1057	20	membranes	membrane	NOUN
fnp-3806	1057	21	from	from	ADP
fnp-3806	1057	22	neural	neural	ADJ
fnp-3806	1057	23	cells	cell	NOUN
fnp-3806	1057	24	.	.	PUNCT
fnp-3806	1058	1	lipids	lipid	NOUN
fnp-3806	1058	2	carry	carry	VERB
fnp-3806	1058	3	out	out	ADP
fnp-3806	1058	4	,	,	PUNCT
fnp-3806	1058	5	in	in	ADP
fnp-3806	1058	6	addition	addition	NOUN
fnp-3806	1058	7	to	to	ADP
fnp-3806	1058	8	structural	structural	ADJ
fnp-3806	1058	9	functions	function	NOUN
fnp-3806	1058	10	,	,	PUNCT
fnp-3806	1058	11	the	the	DET
fnp-3806	1058	12	roles	role	NOUN
fnp-3806	1058	13	of	of	ADP
fnp-3806	1058	14	mediators	mediator	NOUN
fnp-3806	1058	15	or	or	CCONJ
fnp-3806	1058	16	second	second	ADJ
fnp-3806	1058	17	messengers	messenger	NOUN
fnp-3806	1058	18	.	.	PUNCT
fnp-3806	1059	1	these	these	PRON
fnp-3806	1059	2	are	be	AUX
fnp-3806	1059	3	lipophilic	lipophilic	ADJ
fnp-3806	1059	4	molecules	molecule	NOUN
fnp-3806	1059	5	involved	involve	VERB
fnp-3806	1059	6	in	in	ADP
fnp-3806	1059	7	signal	signal	ADJ
fnp-3806	1059	8	transduction	transduction	NOUN
fnp-3806	1059	9	processes	process	NOUN
fnp-3806	1059	10	.	.	PUNCT
fnp-3806	1060	1	lipid	lipid	NOUN
fnp-3806	1060	2	mediators	mediator	NOUN
fnp-3806	1060	3	are	be	AUX
fnp-3806	1060	4	derived	derive	VERB
fnp-3806	1060	5	from	from	ADP
fnp-3806	1060	6	the	the	DET
fnp-3806	1060	7	enzymatic	enzymatic	ADJ
fnp-3806	1060	8	degradation	degradation	NOUN
fnp-3806	1060	9	of	of	ADP
fnp-3806	1060	10	glycerosphingolipids	glycerosphingolipid	NOUN
fnp-3806	1060	11	,	,	PUNCT
fnp-3806	1060	12	sphingolipids	sphingolipid	NOUN
fnp-3806	1060	13	,	,	PUNCT
fnp-3806	1060	14	and	and	CCONJ
fnp-3806	1060	15	cholesterol	cholesterol	NOUN
fnp-3806	1060	16	by	by	ADP
fnp-3806	1060	17	phospholipases	phospholipase	NOUN
fnp-3806	1060	18	,	,	PUNCT
fnp-3806	1060	19	sphingomyelinases	sphingomyelinase	NOUN
fnp-3806	1060	20	,	,	PUNCT
fnp-3806	1060	21	and	and	CCONJ
fnp-3806	1060	22	cytochrome	cytochrome	ADJ
fnp-3806	1060	23	p50	p50	NOUN
fnp-3806	1060	24	hydroxylases	hydroxylase	NOUN
fnp-3806	1060	25	,	,	PUNCT
fnp-3806	1060	26	respectively	respectively	ADV
fnp-3806	1060	27	.	.	PUNCT
fnp-3806	1061	1	eicosanoids	eicosanoid	NOUN
fnp-3806	1061	2	such	such	ADJ
fnp-3806	1061	3	as	as	ADP
fnp-3806	1061	4	prostaglandins	prostaglandin	NOUN
fnp-3806	1061	5	,	,	PUNCT
fnp-3806	1061	6	leukotrienes	leukotriene	NOUN
fnp-3806	1061	7	,	,	PUNCT
fnp-3806	1061	8	and	and	CCONJ
fnp-3806	1061	9	lipoxins	lipoxin	NOUN
fnp-3806	1061	10	are	be	AUX
fnp-3806	1061	11	derived	derive	VERB
fnp-3806	1061	12	from	from	ADP
fnp-3806	1061	13	oxidation	oxidation	NOUN
fnp-3806	1061	14	of	of	ADP
fnp-3806	1061	15	the	the	DET
fnp-3806	1061	16	aa	aa	NOUN
fnp-3806	1061	17	.	.	PUNCT
fnp-3806	1062	1	docosanoids	docosanoid	NOUN
fnp-3806	1062	2	,	,	PUNCT
fnp-3806	1062	3	including	include	VERB
fnp-3806	1062	4	neuroprotectins	neuroprotectin	NOUN
fnp-3806	1062	5	,	,	PUNCT
fnp-3806	1062	6	resolvins	resolvin	NOUN
fnp-3806	1062	7	,	,	PUNCT
fnp-3806	1062	8	and	and	CCONJ
fnp-3806	1062	9	maresin	maresin	NOUN
fnp-3806	1062	10	,	,	PUNCT
fnp-3806	1062	11	are	be	AUX
fnp-3806	1062	12	mediators	mediator	NOUN
fnp-3806	1062	13	of	of	ADP
fnp-3806	1062	14	docosahexanoic	docosahexanoic	ADJ
fnp-3806	1062	15	acid	acid	NOUN
fnp-3806	1062	16	(	(	PUNCT
fnp-3806	1062	17	dha	dha	PROPN
fnp-3806	1062	18	)	)	PUNCT
fnp-3806	1062	19	.	.	PUNCT
fnp-3806	1063	1	these	these	DET
fnp-3806	1063	2	mediators	mediator	NOUN
fnp-3806	1063	3	are	be	AUX
fnp-3806	1063	4	important	important	ADJ
fnp-3806	1063	5	modulators	modulator	NOUN
fnp-3806	1063	6	of	of	ADP
fnp-3806	1063	7	oxidative	oxidative	ADJ
fnp-3806	1063	8	damage	damage	NOUN
fnp-3806	1063	9	,	,	PUNCT
fnp-3806	1063	10	inflammation	inflammation	NOUN
fnp-3806	1063	11	,	,	PUNCT
fnp-3806	1063	12	and	and	CCONJ
fnp-3806	1063	13	apoptosis	apoptosis	NOUN
fnp-3806	1063	14	.	.	PUNCT
fnp-3806	1064	1	other	other	ADJ
fnp-3806	1064	2	glycerophospholipid	glycerophospholipid	NOUN
fnp-3806	1064	3	-	-	PUNCT
fnp-3806	1064	4	derived	derive	VERB
fnp-3806	1064	5	lipid	lipid	NOUN
fnp-3806	1064	6	mediators	mediator	NOUN
fnp-3806	1064	7	are	be	AUX
fnp-3806	1064	8	diacylglycerols	diacylglycerol	NOUN
fnp-3806	1064	9	(	(	PUNCT
fnp-3806	1064	10	dags	dag	NOUN
fnp-3806	1064	11	)	)	PUNCT
fnp-3806	1064	12	phosphatidylinositol	phosphatidylinositol	NOUN
fnp-3806	1064	13	1,4,5	1,4,5	NUM
fnp-3806	1064	14	-	-	NOUN
fnp-3806	1064	15	triphosphates	triphosphate	NOUN
fnp-3806	1064	16	,	,	PUNCT
fnp-3806	1064	17	platelet	platelet	NOUN
fnp-3806	1064	18	-	-	PUNCT
fnp-3806	1064	19	activating	activate	VERB
fnp-3806	1064	20	factor	factor	NOUN
fnp-3806	1064	21	,	,	PUNCT
fnp-3806	1064	22	lysophosphatidic	lysophosphatidic	ADJ
fnp-3806	1064	23	acid	acid	NOUN
fnp-3806	1064	24	,	,	PUNCT
fnp-3806	1064	25	and	and	CCONJ
fnp-3806	1064	26	endocannabinoids	endocannabinoid	NOUN
fnp-3806	1064	27	(	(	PUNCT
fnp-3806	1064	28	1350	1350	NUM
fnp-3806	1064	29	)	)	PUNCT
fnp-3806	1064	30	.	.	PUNCT
fnp-3806	1065	1	degradation	degradation	NOUN
fnp-3806	1065	2	of	of	ADP
fnp-3806	1065	3	sphingolipids	sphingolipid	NOUN
fnp-3806	1065	4	also	also	ADV
fnp-3806	1065	5	results	result	VERB
fnp-3806	1065	6	in	in	ADP
fnp-3806	1065	7	the	the	DET
fnp-3806	1065	8	generation	generation	NOUN
fnp-3806	1065	9	of	of	ADP
fnp-3806	1065	10	mediators	mediator	NOUN
fnp-3806	1065	11	,	,	PUNCT
fnp-3806	1065	12	such	such	ADJ
fnp-3806	1065	13	as	as	ADP
fnp-3806	1065	14	ceramide	ceramide	NOUN
fnp-3806	1065	15	,	,	PUNCT
fnp-3806	1065	16	ceramide	ceramide	NOUN
fnp-3806	1065	17	1	1	NUM
fnp-3806	1065	18	-	-	PUNCT
fnp-3806	1065	19	phosphate	phosphate	NOUN
fnp-3806	1065	20	,	,	PUNCT
fnp-3806	1065	21	sphingosine	sphingosine	NOUN
fnp-3806	1065	22	,	,	PUNCT
fnp-3806	1065	23	and	and	CCONJ
fnp-3806	1065	24	sphingosine	sphingosine	NOUN
fnp-3806	1065	25	1	1	NUM
fnp-3806	1065	26	-	-	NOUN
fnp-3806	1065	27	phosphate	phosphate	NOUN
fnp-3806	1065	28	.	.	PUNCT
fnp-3806	1066	1	these	these	DET
fnp-3806	1066	2	mediators	mediator	NOUN
fnp-3806	1066	3	are	be	AUX
fnp-3806	1066	4	involved	involve	VERB
fnp-3806	1066	5	in	in	ADP
fnp-3806	1066	6	differentiation	differentiation	NOUN
fnp-3806	1066	7	,	,	PUNCT
fnp-3806	1066	8	growth	growth	NOUN
fnp-3806	1066	9	,	,	PUNCT
fnp-3806	1066	10	cell	cell	NOUN
fnp-3806	1066	11	migration	migration	NOUN
fnp-3806	1066	12	,	,	PUNCT
fnp-3806	1066	13	and	and	CCONJ
fnp-3806	1066	14	apoptosis	apoptosis	NOUN
fnp-3806	1066	15	.	.	PUNCT
fnp-3806	1067	1	cholesterol	cholesterol	NOUN
fnp-3806	1067	2	-	-	PUNCT
fnp-3806	1067	3	derived	derive	VERB
fnp-3806	1067	4	lipid	lipid	NOUN
fnp-3806	1067	5	mediators	mediator	NOUN
fnp-3806	1067	6	,	,	PUNCT
fnp-3806	1067	7	including	include	VERB
fnp-3806	1067	8	24and	24and	NOUN
fnp-3806	1067	9	25	25	NUM
fnp-3806	1067	10	-	-	PUNCT
fnp-3806	1067	11	hydroxycholesterol	hydroxycholesterol	NOUN
fnp-3806	1067	12	,	,	PUNCT
fnp-3806	1067	13	produce	produce	VERB
fnp-3806	1067	14	apoptosis	apoptosis	NOUN
fnp-3806	1067	15	(	(	PUNCT
fnp-3806	1067	16	1351	1351	NUM
fnp-3806	1067	17	-	-	SYM
fnp-3806	1067	18	1354	1354	NUM
fnp-3806	1067	19	)	)	PUNCT
fnp-3806	1067	20	.	.	PUNCT
fnp-3806	1068	1	the	the	DET
fnp-3806	1068	2	physical	physical	ADJ
fnp-3806	1068	3	-	-	PUNCT
fnp-3806	1068	4	chemical	chemical	NOUN
fnp-3806	1068	5	properties	property	NOUN
fnp-3806	1068	6	of	of	ADP
fnp-3806	1068	7	the	the	DET
fnp-3806	1068	8	membrane	membrane	NOUN
fnp-3806	1068	9	bilayer	bilayer	NOUN
fnp-3806	1068	10	and	and	CCONJ
fnp-3806	1068	11	the	the	DET
fnp-3806	1068	12	chemical	chemical	NOUN
fnp-3806	1068	13	reactivity	reactivity	NOUN
fnp-3806	1068	14	of	of	ADP
fnp-3806	1068	15	fatty	fatty	ADJ
fnp-3806	1068	16	acids	acid	NOUN
fnp-3806	1068	17	determine	determine	VERB
fnp-3806	1068	18	their	their	PRON
fnp-3806	1068	19	susceptibility	susceptibility	NOUN
fnp-3806	1068	20	to	to	PART
fnp-3806	1068	21	oxidative	oxidative	VERB
fnp-3806	1068	22	damage	damage	NOUN
fnp-3806	1068	23	(	(	PUNCT
fnp-3806	1068	24	1355	1355	NUM
fnp-3806	1068	25	-	-	SYM
fnp-3806	1068	26	1357	1357	NUM
fnp-3806	1068	27	)	)	PUNCT
fnp-3806	1068	28	.	.	PUNCT
fnp-3806	1069	1	ros	ros	PROPN
fnp-3806	1069	2	and	and	CCONJ
fnp-3806	1069	3	reactive	reactive	ADJ
fnp-3806	1069	4	nitrogen	nitrogen	NOUN
fnp-3806	1069	5	species	specie	NOUN
fnp-3806	1069	6	(	(	PUNCT
fnp-3806	1069	7	rns	rn	NOUN
fnp-3806	1069	8	)	)	PUNCT
fnp-3806	1069	9	are	be	AUX
fnp-3806	1069	10	more	more	ADV
fnp-3806	1069	11	soluble	soluble	ADJ
fnp-3806	1069	12	in	in	ADP
fnp-3806	1069	13	the	the	DET
fnp-3806	1069	14	fluid	fluid	ADJ
fnp-3806	1069	15	lipid	lipid	NOUN
fnp-3806	1069	16	bilayer	bilayer	NOUN
fnp-3806	1069	17	than	than	ADP
fnp-3806	1069	18	in	in	ADP
fnp-3806	1069	19	the	the	DET
fnp-3806	1069	20	aqueous	aqueous	ADJ
fnp-3806	1069	21	solution	solution	NOUN
fnp-3806	1069	22	(	(	PUNCT
fnp-3806	1069	23	1358	1358	NUM
fnp-3806	1069	24	,	,	PUNCT
fnp-3806	1069	25	1359	1359	NUM
fnp-3806	1069	26	)	)	PUNCT
fnp-3806	1069	27	.	.	PUNCT
fnp-3806	1070	1	more	more	ADV
fnp-3806	1070	2	importantly	importantly	ADV
fnp-3806	1070	3	,	,	PUNCT
fnp-3806	1070	4	polyunsaturated	polyunsaturated	ADJ
fnp-3806	1070	5	fatty	fatty	NOUN
fnp-3806	1070	6	acid	acid	NOUN
fnp-3806	1070	7	(	(	PUNCT
fnp-3806	1070	8	pufa	pufa	NOUN
fnp-3806	1070	9	)	)	PUNCT
fnp-3806	1070	10	residues	residue	NOUN
fnp-3806	1070	11	of	of	ADP
fnp-3806	1070	12	phospholipids	phospholipid	NOUN
fnp-3806	1070	13	are	be	AUX
fnp-3806	1070	14	very	very	ADV
fnp-3806	1070	15	sensitive	sensitive	ADJ
fnp-3806	1070	16	to	to	ADP
fnp-3806	1070	17	oxidation	oxidation	NOUN
fnp-3806	1070	18	(	(	PUNCT
fnp-3806	1070	19	1360	1360	NUM
fnp-3806	1070	20	)	)	PUNCT
fnp-3806	1070	21	.	.	PUNCT
fnp-3806	1071	1	as	as	ADP
fnp-3806	1071	2	a	a	DET
fnp-3806	1071	3	result	result	NOUN
fnp-3806	1071	4	,	,	PUNCT
fnp-3806	1071	5	neural	neural	ADJ
fnp-3806	1071	6	cell	cell	NOUN
fnp-3806	1071	7	membrane	membrane	NOUN
fnp-3806	1071	8	lipids	lipid	NOUN
fnp-3806	1071	9	become	become	VERB
fnp-3806	1071	10	primary	primary	ADJ
fnp-3806	1071	11	targets	target	NOUN
fnp-3806	1071	12	of	of	ADP
fnp-3806	1071	13	oxidative	oxidative	ADJ
fnp-3806	1071	14	damage	damage	NOUN
fnp-3806	1071	15	and	and	CCONJ
fnp-3806	1071	16	lipid	lipid	NOUN
fnp-3806	1071	17	peroxidation	peroxidation	NOUN
fnp-3806	1071	18	.	.	PUNCT
fnp-3806	1072	1	in	in	ADP
fnp-3806	1072	2	the	the	DET
fnp-3806	1072	3	aging	age	VERB
fnp-3806	1072	4	brain	brain	NOUN
fnp-3806	1072	5	,	,	PUNCT
fnp-3806	1072	6	there	there	PRON
fnp-3806	1072	7	is	be	VERB
fnp-3806	1072	8	a	a	DET
fnp-3806	1072	9	progressive	progressive	ADJ
fnp-3806	1072	10	decrease	decrease	NOUN
fnp-3806	1072	11	in	in	ADP
fnp-3806	1072	12	the	the	DET
fnp-3806	1072	13	levels	level	NOUN
fnp-3806	1072	14	of	of	ADP
fnp-3806	1072	15	cholesterol	cholesterol	NOUN
fnp-3806	1072	16	,	,	PUNCT
fnp-3806	1072	17	phosphatidylethanolamine	phosphatidylethanolamine	NOUN
fnp-3806	1072	18	,	,	PUNCT
fnp-3806	1072	19	phosphatidyl	phosphatidyl	NOUN
fnp-3806	1072	20	inositol	inositol	NOUN
fnp-3806	1072	21	,	,	PUNCT
fnp-3806	1072	22	phospholipid	phospholipid	NOUN
fnp-3806	1072	23	,	,	PUNCT
fnp-3806	1072	24	ethanolamine	ethanolamine	NOUN
fnp-3806	1072	25	plasmalogen	plasmalogen	NOUN
fnp-3806	1072	26	,	,	PUNCT
fnp-3806	1072	27	and	and	CCONJ
fnp-3806	1072	28	sphingomyelin	sphingomyelin	NOUN
fnp-3806	1072	29	(	(	PUNCT
fnp-3806	1072	30	1361	1361	NUM
fnp-3806	1072	31	-	-	SYM
fnp-3806	1072	32	1366	1366	NUM
fnp-3806	1072	33	)	)	PUNCT
fnp-3806	1072	34	.	.	PUNCT
fnp-3806	1073	1	increasing	increase	VERB
fnp-3806	1073	2	age	age	NOUN
fnp-3806	1073	3	is	be	AUX
fnp-3806	1073	4	associated	associate	VERB
fnp-3806	1073	5	with	with	ADP
fnp-3806	1073	6	progressive	progressive	ADJ
fnp-3806	1073	7	modifications	modification	NOUN
fnp-3806	1073	8	in	in	ADP
fnp-3806	1073	9	the	the	DET
fnp-3806	1073	10	composition	composition	NOUN
fnp-3806	1073	11	of	of	ADP
fnp-3806	1073	12	pufa	pufa	NOUN
fnp-3806	1073	13	,	,	PUNCT
fnp-3806	1073	14	including	include	VERB
fnp-3806	1073	15	dha	dha	PROPN
fnp-3806	1073	16	and	and	CCONJ
fnp-3806	1073	17	aa	aa	PROPN
fnp-3806	1073	18	levels	level	NOUN
fnp-3806	1073	19	(	(	PUNCT
fnp-3806	1073	20	1367	1367	NUM
fnp-3806	1073	21	)	)	PUNCT
fnp-3806	1073	22	.	.	PUNCT
fnp-3806	1074	1	the	the	DET
fnp-3806	1074	2	age	age	NOUN
fnp-3806	1074	3	-	-	PUNCT
fnp-3806	1074	4	related	relate	VERB
fnp-3806	1074	5	reduction	reduction	NOUN
fnp-3806	1074	6	in	in	ADP
fnp-3806	1074	7	pufas	pufas	NOUN
fnp-3806	1074	8	is	be	AUX
fnp-3806	1074	9	inversely	inversely	ADV
fnp-3806	1074	10	correlated	correlate	VERB
fnp-3806	1074	11	with	with	ADP
fnp-3806	1074	12	stearoyl	stearoyl	NOUN
fnp-3806	1074	13	-	-	PUNCT
fnp-3806	1074	14	coa	coa	NOUN
fnp-3806	1074	15	desaturase	desaturase	NOUN
fnp-3806	1074	16	expression	expression	NOUN
fnp-3806	1074	17	and	and	CCONJ
fnp-3806	1074	18	activity	activity	NOUN
fnp-3806	1074	19	,	,	PUNCT
fnp-3806	1074	20	resulting	result	VERB
fnp-3806	1074	21	in	in	ADP
fnp-3806	1074	22	higher	high	ADJ
fnp-3806	1074	23	levels	level	NOUN
fnp-3806	1074	24	of	of	ADP
fnp-3806	1074	25	monounsaturated	monounsaturated	ADJ
fnp-3806	1074	26	fatty	fatty	NOUN
fnp-3806	1074	27	acids	acid	NOUN
fnp-3806	1074	28	(	(	PUNCT
fnp-3806	1074	29	mufas	mufas	NOUN
fnp-3806	1074	30	)	)	PUNCT
fnp-3806	1074	31	.	.	PUNCT
fnp-3806	1075	1	lipofuscin	lipofuscin	PROPN
fnp-3806	1075	2	located	locate	VERB
fnp-3806	1075	3	in	in	ADP
fnp-3806	1075	4	secondary	secondary	ADJ
fnp-3806	1075	5	lysosomes	lysosome	NOUN
fnp-3806	1075	6	increases	increase	NOUN
fnp-3806	1075	7	with	with	ADP
fnp-3806	1075	8	age	age	NOUN
fnp-3806	1075	9	in	in	ADP
fnp-3806	1075	10	neurons	neuron	NOUN
fnp-3806	1075	11	and	and	CCONJ
fnp-3806	1075	12	glial	glial	ADJ
fnp-3806	1075	13	cells	cell	NOUN
fnp-3806	1075	14	(	(	PUNCT
fnp-3806	1075	15	1368	1368	NUM
fnp-3806	1075	16	,	,	PUNCT
fnp-3806	1075	17	1369	1369	NUM
fnp-3806	1075	18	)	)	PUNCT
fnp-3806	1075	19	.	.	PUNCT
fnp-3806	1076	1	the	the	DET
fnp-3806	1076	2	“	"	PUNCT
fnp-3806	1076	3	aging	age	VERB
fnp-3806	1076	4	pigment	pigment	NOUN
fnp-3806	1076	5	”	"	PUNCT
fnp-3806	1076	6	is	be	AUX
fnp-3806	1076	7	composed	compose	VERB
fnp-3806	1076	8	of	of	ADP
fnp-3806	1076	9	two	two	NUM
fnp-3806	1076	10	-	-	PUNCT
fnp-3806	1076	11	thirds	third	NOUN
fnp-3806	1076	12	protein	protein	NOUN
fnp-3806	1076	13	and	and	CCONJ
fnp-3806	1076	14	one	one	NUM
fnp-3806	1076	15	third	third	ADJ
fnp-3806	1076	16	lipids	lipid	NOUN
fnp-3806	1076	17	(	(	PUNCT
fnp-3806	1076	18	1370	1370	NUM
fnp-3806	1076	19	,	,	PUNCT
fnp-3806	1076	20	1371	1371	NUM
fnp-3806	1076	21	)	)	PUNCT
fnp-3806	1076	22	.	.	PUNCT
fnp-3806	1077	1	proteins	protein	NOUN
fnp-3806	1077	2	in	in	ADP
fnp-3806	1077	3	lipofuscin	lipofuscin	NUM
fnp-3806	1077	4	belong	belong	VERB
fnp-3806	1077	5	to	to	ADP
fnp-3806	1077	6	the	the	DET
fnp-3806	1077	7	cytoskeleton	cytoskeleton	NOUN
fnp-3806	1077	8	,	,	PUNCT
fnp-3806	1077	9	mitochondrial	mitochondrial	ADJ
fnp-3806	1077	10	bioenergetics	bioenergetic	NOUN
fnp-3806	1077	11	,	,	PUNCT
fnp-3806	1077	12	synapse	synapse	NOUN
fnp-3806	1077	13	,	,	PUNCT
fnp-3806	1077	14	and	and	CCONJ
fnp-3806	1077	15	membrane	membrane	NOUN
fnp-3806	1077	16	receptors	receptor	NOUN
fnp-3806	1077	17	(	(	PUNCT
fnp-3806	1077	18	1372	1372	NUM
fnp-3806	1077	19	)	)	PUNCT
fnp-3806	1077	20	.	.	PUNCT
fnp-3806	1078	1	this	this	DET
fnp-3806	1078	2	proteome	proteome	PROPN
fnp-3806	1078	3	is	be	AUX
fnp-3806	1078	4	practically	practically	ADV
fnp-3806	1078	5	identical	identical	ADJ
fnp-3806	1078	6	to	to	ADP
fnp-3806	1078	7	the	the	DET
fnp-3806	1078	8	proteome	proteome	NOUN
fnp-3806	1078	9	derived	derive	VERB
fnp-3806	1078	10	from	from	ADP
fnp-3806	1078	11	lipoxidation	lipoxidation	NOUN
fnp-3806	1078	12	reactions	reaction	NOUN
fnp-3806	1078	13	identified	identify	VERB
fnp-3806	1078	14	in	in	ADP
fnp-3806	1078	15	the	the	DET
fnp-3806	1078	16	frontal	frontal	ADJ
fnp-3806	1078	17	cortex	cortex	NOUN
fnp-3806	1078	18	of	of	ADP
fnp-3806	1078	19	aged	aged	ADJ
fnp-3806	1078	20	humans	human	NOUN
fnp-3806	1078	21	(	(	PUNCT
fnp-3806	1078	22	1373	1373	NUM
fnp-3806	1078	23	)	)	PUNCT
fnp-3806	1078	24	.	.	PUNCT
fnp-3806	1079	1	levels	level	NOUN
fnp-3806	1079	2	of	of	ADP
fnp-3806	1079	3	glycerophospholipids	glycerophospholipid	NOUN
fnp-3806	1079	4	,	,	PUNCT
fnp-3806	1079	5	sphingolipids	sphingolipid	NOUN
fnp-3806	1079	6	,	,	PUNCT
fnp-3806	1079	7	dags	dag	NOUN
fnp-3806	1079	8	,	,	PUNCT
fnp-3806	1079	9	and	and	CCONJ
fnp-3806	1079	10	plasmalogens	plasmalogen	NOUN
fnp-3806	1079	11	are	be	AUX
fnp-3806	1079	12	altered	alter	VERB
fnp-3806	1079	13	in	in	ADP
fnp-3806	1079	14	the	the	DET
fnp-3806	1079	15	brain	brain	NOUN
fnp-3806	1079	16	in	in	ADP
fnp-3806	1079	17	sad	sad	ADJ
fnp-3806	1079	18	(	(	PUNCT
fnp-3806	1079	19	1374	1374	NUM
fnp-3806	1079	20	-	-	SYM
fnp-3806	1079	21	1379	1379	NUM
fnp-3806	1079	22	)	)	PUNCT
fnp-3806	1079	23	.	.	PUNCT
fnp-3806	1080	1	the	the	DET
fnp-3806	1080	2	disturbance	disturbance	NOUN
fnp-3806	1080	3	of	of	ADP
fnp-3806	1080	4	human	human	ADJ
fnp-3806	1080	5	brain	brain	NOUN
fnp-3806	1080	6	lipid	lipid	NOUN
fnp-3806	1080	7	content	content	NOUN
fnp-3806	1080	8	in	in	ADP
fnp-3806	1080	9	sad	sad	ADJ
fnp-3806	1080	10	pathology	pathology	NOUN
fnp-3806	1080	11	may	may	AUX
fnp-3806	1080	12	be	be	AUX
fnp-3806	1080	13	categorized	categorize	VERB
fnp-3806	1080	14	into	into	ADP
fnp-3806	1080	15	four	four	NUM
fnp-3806	1080	16	main	main	ADJ
fnp-3806	1080	17	groups	group	NOUN
fnp-3806	1080	18	(	(	PUNCT
fnp-3806	1080	19	i	i	NOUN
fnp-3806	1080	20	)	)	PUNCT
fnp-3806	1080	21	decreased	decrease	VERB
fnp-3806	1080	22	expression	expression	NOUN
fnp-3806	1080	23	of	of	ADP
fnp-3806	1080	24	phospholipids	phospholipid	NOUN
fnp-3806	1080	25	,	,	PUNCT
fnp-3806	1080	26	specifically	specifically	ADV
fnp-3806	1080	27	plasmalogen	plasmalogen	NOUN
fnp-3806	1080	28	pe	pe	NOUN
fnp-3806	1080	29	and	and	CCONJ
fnp-3806	1080	30	plasmalogen	plasmalogen	NOUN
fnp-3806	1080	31	pc	pc	NOUN
fnp-3806	1080	32	,	,	PUNCT
fnp-3806	1080	33	due	due	ADJ
fnp-3806	1080	34	in	in	ADP
fnp-3806	1080	35	part	part	NOUN
fnp-3806	1080	36	to	to	ADP
fnp-3806	1080	37	abnormal	abnormal	ADJ
fnp-3806	1080	38	peroxisome	peroxisome	NOUN
fnp-3806	1080	39	activity	activity	NOUN
fnp-3806	1080	40	;	;	PUNCT
fnp-3806	1080	41	(	(	PUNCT
fnp-3806	1080	42	ii	ii	NOUN
fnp-3806	1080	43	)	)	PUNCT
fnp-3806	1080	44	reduced	reduce	VERB
fnp-3806	1080	45	sulfatide	sulfatide	NOUN
fnp-3806	1080	46	content	content	PROPN
fnp-3806	1080	47	;	;	PUNCT
fnp-3806	1080	48	iii	iii	X
fnp-3806	1080	49	)	)	PUNCT
fnp-3806	1080	50	increased	increase	VERB
fnp-3806	1080	51	levels	level	NOUN
fnp-3806	1080	52	of	of	ADP
fnp-3806	1080	53	ceramides	ceramide	NOUN
fnp-3806	1080	54	;	;	PUNCT
fnp-3806	1080	55	and	and	CCONJ
fnp-3806	1080	56	(	(	PUNCT
fnp-3806	1080	57	iv	iv	X
fnp-3806	1080	58	)	)	PUNCT
fnp-3806	1080	59	increased	increase	VERB
fnp-3806	1080	60	lipoxidative	lipoxidative	ADJ
fnp-3806	1080	61	stress	stress	NOUN
fnp-3806	1080	62	(	(	PUNCT
fnp-3806	1080	63	1354	1354	NUM
fnp-3806	1080	64	)	)	PUNCT
fnp-3806	1080	65	.	.	PUNCT
fnp-3806	1081	1	plasmalogen	plasmalogen	PROPN
fnp-3806	1081	2	pe	pe	PROPN
fnp-3806	1081	3	plays	play	VERB
fnp-3806	1081	4	a	a	DET
fnp-3806	1081	5	particular	particular	ADJ
fnp-3806	1081	6	role	role	NOUN
fnp-3806	1081	7	as	as	ADP
fnp-3806	1081	8	anti	anti	ADJ
fnp-3806	1081	9	-	-	ADJ
fnp-3806	1081	10	oxidant	oxidant	ADJ
fnp-3806	1081	11	(	(	PUNCT
fnp-3806	1081	12	1380	1380	NUM
fnp-3806	1081	13	)	)	PUNCT
fnp-3806	1081	14	.	.	PUNCT
fnp-3806	1082	1	moreover	moreover	ADV
fnp-3806	1082	2	,	,	PUNCT
fnp-3806	1082	3	in	in	ADP
fnp-3806	1082	4	gray	gray	ADJ
fnp-3806	1082	5	matter	matter	NOUN
fnp-3806	1082	6	,	,	PUNCT
fnp-3806	1082	7	the	the	DET
fnp-3806	1082	8	major	major	ADJ
fnp-3806	1082	9	ppe	ppe	NOUN
fnp-3806	1082	10	molecular	molecular	ADJ
fnp-3806	1082	11	species	specie	NOUN
fnp-3806	1082	12	are	be	AUX
fnp-3806	1082	13	enriched	enrich	VERB
fnp-3806	1082	14	in	in	ADP
fnp-3806	1082	15	dha	dha	PROPN
fnp-3806	1082	16	and	and	CCONJ
fnp-3806	1082	17	aa	aa	PROPN
fnp-3806	1082	18	.	.	PUNCT
fnp-3806	1083	1	modifications	modification	NOUN
fnp-3806	1083	2	in	in	ADP
fnp-3806	1083	3	dha	dha	PROPN
fnp-3806	1083	4	,	,	PUNCT
fnp-3806	1083	5	aa	aa	NOUN
fnp-3806	1083	6	,	,	PUNCT
fnp-3806	1083	7	and	and	CCONJ
fnp-3806	1083	8	pufas	pufas	NOUN
fnp-3806	1083	9	in	in	ADP
fnp-3806	1083	10	sad	sad	ADJ
fnp-3806	1083	11	produce	produce	VERB
fnp-3806	1083	12	an	an	DET
fnp-3806	1083	13	imbalance	imbalance	NOUN
fnp-3806	1083	14	between	between	ADP
fnp-3806	1083	15	their	their	PRON
fnp-3806	1083	16	protective	protective	ADJ
fnp-3806	1083	17	role	role	NOUN
fnp-3806	1083	18	(	(	PUNCT
fnp-3806	1083	19	the	the	DET
fnp-3806	1083	20	adaptive	adaptive	ADJ
fnp-3806	1083	21	responses	response	NOUN
fnp-3806	1083	22	derived	derive	VERB
fnp-3806	1083	23	from	from	ADP
fnp-3806	1083	24	their	their	PRON
fnp-3806	1083	25	lipid	lipid	ADJ
fnp-3806	1083	26	mediators	mediator	NOUN
fnp-3806	1083	27	)	)	PUNCT
fnp-3806	1083	28	and	and	CCONJ
fnp-3806	1083	29	a	a	DET
fnp-3806	1083	30	deleterious	deleterious	ADJ
fnp-3806	1083	31	role	role	NOUN
fnp-3806	1083	32	(	(	PUNCT
fnp-3806	1083	33	derived	derive	VERB
fnp-3806	1083	34	from	from	ADP
fnp-3806	1083	35	their	their	PRON
fnp-3806	1083	36	susceptibility	susceptibility	NOUN
fnp-3806	1083	37	to	to	ADP
fnp-3806	1083	38	oxidation	oxidation	NOUN
fnp-3806	1083	39	)	)	PUNCT
fnp-3806	1083	40	(	(	PUNCT
fnp-3806	1083	41	1381	1381	NUM
fnp-3806	1083	42	,	,	PUNCT
fnp-3806	1083	43	1382	1382	NUM
fnp-3806	1083	44	)	)	PUNCT
fnp-3806	1083	45	.	.	PUNCT
fnp-3806	1084	1	lipid	lipid	NOUN
fnp-3806	1084	2	peroxidation	peroxidation	NOUN
fnp-3806	1084	3	is	be	AUX
fnp-3806	1084	4	an	an	DET
fnp-3806	1084	5	early	early	ADJ
fnp-3806	1084	6	event	event	NOUN
fnp-3806	1084	7	and	and	CCONJ
fnp-3806	1084	8	a	a	DET
fnp-3806	1084	9	major	major	ADJ
fnp-3806	1084	10	cause	cause	NOUN
fnp-3806	1084	11	of	of	ADP
fnp-3806	1084	12	oxidative	oxidative	ADJ
fnp-3806	1084	13	stress	stress	NOUN
fnp-3806	1084	14	damage	damage	NOUN
fnp-3806	1084	15	in	in	ADP
fnp-3806	1084	16	sad	sad	ADJ
fnp-3806	1084	17	progression	progression	NOUN
fnp-3806	1084	18	(	(	PUNCT
fnp-3806	1084	19	1373	1373	NUM
fnp-3806	1084	20	,	,	PUNCT
fnp-3806	1084	21	1381	1381	NUM
fnp-3806	1084	22	)	)	PUNCT
fnp-3806	1084	23	.	.	PUNCT
fnp-3806	1085	1	β	β	X
fnp-3806	1085	2	-	-	PUNCT
fnp-3806	1085	3	amyloid	amyloid	NOUN
fnp-3806	1085	4	plays	play	VERB
fnp-3806	1085	5	an	an	DET
fnp-3806	1085	6	important	important	ADJ
fnp-3806	1085	7	part	part	NOUN
fnp-3806	1085	8	since	since	SCONJ
fnp-3806	1085	9	sps	sps	PROPN
fnp-3806	1085	10	are	be	AUX
fnp-3806	1085	11	always	always	ADV
fnp-3806	1085	12	surrounded	surround	VERB
fnp-3806	1085	13	by	by	ADP
fnp-3806	1085	14	oxidized	oxidize	VERB
fnp-3806	1085	15	lipids	lipid	NOUN
fnp-3806	1085	16	,	,	PUNCT
fnp-3806	1085	17	as	as	SCONJ
fnp-3806	1085	18	revealed	reveal	VERB
fnp-3806	1085	19	using	use	VERB
fnp-3806	1085	20	fourier	fourier	NOUN
fnp-3806	1085	21	transform	transform	VERB
fnp-3806	1085	22	infrared	infrared	ADJ
fnp-3806	1085	23	microscopy	microscopy	NOUN
fnp-3806	1085	24	(	(	PUNCT
fnp-3806	1085	25	1383	1383	NUM
fnp-3806	1085	26	)	)	PUNCT
fnp-3806	1085	27	.	.	PUNCT
fnp-3806	1086	1	one	one	NUM
fnp-3806	1086	2	mechanism	mechanism	NOUN
fnp-3806	1086	3	to	to	PART
fnp-3806	1086	4	modulate	modulate	VERB
fnp-3806	1086	5	oxidative	oxidative	ADJ
fnp-3806	1086	6	damage	damage	NOUN
fnp-3806	1086	7	is	be	AUX
fnp-3806	1086	8	mediation	mediation	NOUN
fnp-3806	1086	9	by	by	ADP
fnp-3806	1086	10	the	the	DET
fnp-3806	1086	11	upregulation	upregulation	NOUN
fnp-3806	1086	12	of	of	ADP
fnp-3806	1086	13	dha	dha	PROPN
fnp-3806	1086	14	synthesis	synthesis	PROPN
fnp-3806	1086	15	,	,	PUNCT
fnp-3806	1086	16	which	which	PRON
fnp-3806	1086	17	occurs	occur	VERB
fnp-3806	1086	18	in	in	ADP
fnp-3806	1086	19	selected	select	VERB
fnp-3806	1086	20	regions	region	NOUN
fnp-3806	1086	21	at	at	ADP
fnp-3806	1086	22	early	early	ADJ
fnp-3806	1086	23	stages	stage	NOUN
fnp-3806	1086	24	of	of	ADP
fnp-3806	1086	25	sad	sad	ADJ
fnp-3806	1086	26	;	;	PUNCT
fnp-3806	1086	27	this	this	PRON
fnp-3806	1086	28	is	be	AUX
fnp-3806	1086	29	followed	follow	VERB
fnp-3806	1086	30	by	by	ADP
fnp-3806	1086	31	an	an	DET
fnp-3806	1086	32	adaptation	adaptation	NOUN
fnp-3806	1086	33	,	,	PUNCT
fnp-3806	1086	34	and	and	CCONJ
fnp-3806	1086	35	then	then	ADV
fnp-3806	1086	36	decreased	decrease	VERB
fnp-3806	1086	37	dha	dha	PROPN
fnp-3806	1086	38	contents	content	NOUN
fnp-3806	1086	39	.	.	PUNCT
fnp-3806	1087	1	this	this	DET
fnp-3806	1087	2	change	change	NOUN
fnp-3806	1087	3	is	be	AUX
fnp-3806	1087	4	not	not	PART
fnp-3806	1087	5	uniform	uniform	ADJ
fnp-3806	1087	6	,	,	PUNCT
fnp-3806	1087	7	but	but	CCONJ
fnp-3806	1087	8	rather	rather	ADV
fnp-3806	1087	9	regionand	regionand	VERB
fnp-3806	1087	10	stage	stage	NOUN
fnp-3806	1087	11	-	-	PUNCT
fnp-3806	1087	12	dependent	dependent	ADJ
fnp-3806	1087	13	.	.	PUNCT
fnp-3806	1088	1	dha	dha	PROPN
fnp-3806	1088	2	content	content	PROPN
fnp-3806	1088	3	in	in	ADP
fnp-3806	1088	4	sad	sad	ADJ
fnp-3806	1088	5	progression	progression	NOUN
fnp-3806	1088	6	is	be	AUX
fnp-3806	1088	7	like	like	ADP
fnp-3806	1088	8	a	a	DET
fnp-3806	1088	9	shock	shock	NOUN
fnp-3806	1088	10	wave	wave	NOUN
fnp-3806	1088	11	manifested	manifest	VERB
fnp-3806	1088	12	in	in	ADP
fnp-3806	1088	13	three	three	NUM
fnp-3806	1088	14	steps	step	NOUN
fnp-3806	1088	15	:	:	PUNCT
fnp-3806	1088	16	upregulation	upregulation	NOUN
fnp-3806	1088	17	,	,	PUNCT
fnp-3806	1088	18	adaptation	adaptation	NOUN
fnp-3806	1088	19	,	,	PUNCT
fnp-3806	1088	20	and	and	CCONJ
fnp-3806	1088	21	depletion	depletion	NOUN
fnp-3806	1088	22	.	.	PUNCT
fnp-3806	1089	1	crucial	crucial	ADJ
fnp-3806	1089	2	information	information	NOUN
fnp-3806	1089	3	connecting	connect	VERB
fnp-3806	1089	4	lipid	lipid	NOUN
fnp-3806	1089	5	alterations	alteration	NOUN
fnp-3806	1089	6	and	and	CCONJ
fnp-3806	1089	7	sad	sad	ADJ
fnp-3806	1089	8	comes	come	VERB
fnp-3806	1089	9	from	from	ADP
fnp-3806	1089	10	genetic	genetic	ADJ
fnp-3806	1089	11	data	datum	NOUN
fnp-3806	1089	12	.	.	PUNCT
fnp-3806	1090	1	in	in	ADP
fnp-3806	1090	2	addition	addition	NOUN
fnp-3806	1090	3	to	to	ADP
fnp-3806	1090	4	allele	allele	PROPN
fnp-3806	1090	5	ε4	ε4	PROPN
fnp-3806	1090	6	of	of	ADP
fnp-3806	1090	7	apoe	apoe	PROPN
fnp-3806	1090	8	(	(	PUNCT
fnp-3806	1090	9	268	268	NUM
fnp-3806	1090	10	-	-	SYM
fnp-3806	1090	11	271	271	NUM
fnp-3806	1090	12	,	,	PUNCT
fnp-3806	1090	13	1384	1384	NUM
fnp-3806	1090	14	,	,	PUNCT
fnp-3806	1090	15	1385	1385	NUM
fnp-3806	1090	16	)	)	PUNCT
fnp-3806	1090	17	,	,	PUNCT
fnp-3806	1090	18	many	many	ADJ
fnp-3806	1090	19	genes	gene	NOUN
fnp-3806	1090	20	involved	involve	VERB
fnp-3806	1090	21	in	in	ADP
fnp-3806	1090	22	sad	sad	ADJ
fnp-3806	1090	23	are	be	AUX
fnp-3806	1090	24	linked	link	VERB
fnp-3806	1090	25	to	to	ADP
fnp-3806	1090	26	cholesterol	cholesterol	NOUN
fnp-3806	1090	27	and	and	CCONJ
fnp-3806	1090	28	lipid	lipid	NOUN
fnp-3806	1090	29	metabolism	metabolism	NOUN
fnp-3806	1090	30	(	(	PUNCT
fnp-3806	1090	31	284	284	NUM
fnp-3806	1090	32	,	,	PUNCT
fnp-3806	1090	33	1386	1386	NUM
fnp-3806	1090	34	-	-	SYM
fnp-3806	1090	35	1391	1391	NUM
fnp-3806	1090	36	)	)	PUNCT
fnp-3806	1090	37	.	.	PUNCT
fnp-3806	1091	1	most	most	ADJ
fnp-3806	1091	2	of	of	ADP
fnp-3806	1091	3	them	they	PRON
fnp-3806	1091	4	increase	increase	VERB
fnp-3806	1091	5	the	the	DET
fnp-3806	1091	6	risk	risk	NOUN
fnp-3806	1091	7	of	of	ADP
fnp-3806	1091	8	β	β	NOUN
fnp-3806	1091	9	-	-	NOUN
fnp-3806	1091	10	amyloid	amyloid	NOUN
fnp-3806	1091	11	deposition	deposition	NOUN
fnp-3806	1091	12	but	but	CCONJ
fnp-3806	1091	13	apoeε2	apoeε2	PROPN
fnp-3806	1091	14	allele	allele	NOUN
fnp-3806	1091	15	appears	appear	VERB
fnp-3806	1091	16	to	to	PART
fnp-3806	1091	17	decrease	decrease	VERB
fnp-3806	1091	18	it	it	PRON
fnp-3806	1091	19	(	(	PUNCT
fnp-3806	1091	20	1392	1392	NUM
fnp-3806	1091	21	,	,	PUNCT
fnp-3806	1091	22	1393	1393	NUM
fnp-3806	1091	23	)	)	PUNCT
fnp-3806	1091	24	.	.	PUNCT
fnp-3806	1092	1	22c	22c	NOUN
fnp-3806	1092	2	.	.	PUNCT
fnp-3806	1093	1	lipid	lipid	ADJ
fnp-3806	1093	2	rafts	raft	NOUN
fnp-3806	1093	3	and	and	CCONJ
fnp-3806	1093	4	cell	cell	NOUN
fnp-3806	1093	5	membranes	membrane	NOUN
fnp-3806	1093	6	lipid	lipid	NOUN
fnp-3806	1093	7	rafts	raft	NOUN
fnp-3806	1093	8	are	be	AUX
fnp-3806	1093	9	microdomains	microdomain	NOUN
fnp-3806	1093	10	of	of	ADP
fnp-3806	1093	11	cell	cell	NOUN
fnp-3806	1093	12	membranes	membrane	NOUN
fnp-3806	1093	13	enriched	enrich	VERB
fnp-3806	1093	14	in	in	ADP
fnp-3806	1093	15	glycosphingolipids	glycosphingolipid	NOUN
fnp-3806	1093	16	,	,	PUNCT
fnp-3806	1093	17	cholesterol	cholesterol	NOUN
fnp-3806	1093	18	,	,	PUNCT
fnp-3806	1093	19	and	and	CCONJ
fnp-3806	1093	20	protein	protein	NOUN
fnp-3806	1093	21	receptors	receptor	NOUN
fnp-3806	1093	22	which	which	PRON
fnp-3806	1093	23	favor	favor	VERB
fnp-3806	1093	24	multiple	multiple	ADJ
fnp-3806	1093	25	cell	cell	NOUN
fnp-3806	1093	26	signaling	signal	VERB
fnp-3806	1093	27	interactions	interaction	NOUN
fnp-3806	1093	28	at	at	ADP
fnp-3806	1093	29	the	the	DET
fnp-3806	1093	30	cell	cell	NOUN
fnp-3806	1093	31	membrane	membrane	NOUN
fnp-3806	1093	32	,	,	PUNCT
fnp-3806	1093	33	necessary	necessary	ADJ
fnp-3806	1093	34	for	for	ADP
fnp-3806	1093	35	signal	signal	ADJ
fnp-3806	1093	36	transduction	transduction	NOUN
fnp-3806	1093	37	(	(	PUNCT
fnp-3806	1093	38	1394	1394	NUM
fnp-3806	1093	39	,	,	PUNCT
fnp-3806	1093	40	1395	1395	NUM
fnp-3806	1093	41	)	)	PUNCT
fnp-3806	1093	42	.	.	PUNCT
fnp-3806	1094	1	the	the	DET
fnp-3806	1094	2	exoplasmic	exoplasmic	PROPN
fnp-3806	1094	3	leaflet	leaflet	NOUN
fnp-3806	1094	4	is	be	AUX
fnp-3806	1094	5	enriched	enrich	VERB
fnp-3806	1094	6	with	with	ADP
fnp-3806	1094	7	glycosphingolipids	glycosphingolipid	NOUN
fnp-3806	1094	8	and	and	CCONJ
fnp-3806	1094	9	sphingomyelin	sphingomyelin	NOUN
fnp-3806	1094	10	,	,	PUNCT
fnp-3806	1094	11	the	the	DET
fnp-3806	1094	12	cytoplasmic	cytoplasmic	ADJ
fnp-3806	1094	13	leaflet	leaflet	NOUN
fnp-3806	1094	14	is	be	AUX
fnp-3806	1094	15	enriched	enrich	VERB
fnp-3806	1094	16	with	with	ADP
fnp-3806	1094	17	glycerolipids	glycerolipid	NOUN
fnp-3806	1094	18	;	;	PUNCT
fnp-3806	1094	19	cholesterol	cholesterol	NOUN
fnp-3806	1094	20	is	be	AUX
fnp-3806	1094	21	present	present	ADJ
fnp-3806	1094	22	in	in	ADP
fnp-3806	1094	23	both	both	PRON
fnp-3806	1094	24	.	.	PUNCT
fnp-3806	1095	1	the	the	DET
fnp-3806	1095	2	lipid	lipid	NOUN
fnp-3806	1095	3	composition	composition	NOUN
fnp-3806	1095	4	makes	make	VERB
fnp-3806	1095	5	this	this	DET
fnp-3806	1095	6	system	system	NOUN
fnp-3806	1095	7	highly	highly	ADV
fnp-3806	1095	8	dynamic	dynamic	ADJ
fnp-3806	1095	9	in	in	ADP
fnp-3806	1095	10	that	that	DET
fnp-3806	1095	11	several	several	ADJ
fnp-3806	1095	12	proteins	protein	NOUN
fnp-3806	1095	13	act	act	NOUN
fnp-3806	1095	14	as	as	ADP
fnp-3806	1095	15	structural	structural	ADJ
fnp-3806	1095	16	proteins	protein	NOUN
fnp-3806	1095	17	,	,	PUNCT
fnp-3806	1095	18	transmembrane	transmembrane	ADJ
fnp-3806	1095	19	signaling	signal	VERB
fnp-3806	1095	20	proteins	protein	NOUN
fnp-3806	1095	21	,	,	PUNCT
fnp-3806	1095	22	and	and	CCONJ
fnp-3806	1095	23	protein	protein	NOUN
fnp-3806	1095	24	anchors	anchor	NOUN
fnp-3806	1095	25	linked	link	VERB
fnp-3806	1095	26	to	to	ADP
fnp-3806	1095	27	protein	protein	NOUN
fnp-3806	1095	28	-	-	PUNCT
fnp-3806	1095	29	protein	protein	NOUN
fnp-3806	1095	30	interactions	interaction	NOUN
fnp-3806	1095	31	(	(	PUNCT
fnp-3806	1095	32	1396	1396	NUM
fnp-3806	1095	33	)	)	PUNCT
fnp-3806	1095	34	.	.	PUNCT
fnp-3806	1096	1	cholesterol	cholesterol	NOUN
fnp-3806	1096	2	in	in	ADP
fnp-3806	1096	3	lipid	lipid	ADJ
fnp-3806	1096	4	rafts	raft	NOUN
fnp-3806	1096	5	facilitates	facilitate	VERB
fnp-3806	1096	6	the	the	DET
fnp-3806	1096	7	clustering	clustering	NOUN
fnp-3806	1096	8	of	of	ADP
fnp-3806	1096	9	αand	αand	ADV
fnp-3806	1096	10	β	β	NOUN
fnp-3806	1096	11	-	-	NOUN
fnp-3806	1096	12	secretases	secretase	NOUN
fnp-3806	1096	13	.	.	PUNCT
fnp-3806	1097	1	although	although	SCONJ
fnp-3806	1097	2	cholesterol	cholesterol	NOUN
fnp-3806	1097	3	does	do	AUX
fnp-3806	1097	4	not	not	PART
fnp-3806	1097	5	have	have	VERB
fnp-3806	1097	6	a	a	DET
fnp-3806	1097	7	direct	direct	ADJ
fnp-3806	1097	8	effect	effect	NOUN
fnp-3806	1097	9	on	on	ADP
fnp-3806	1097	10	γ	γ	NOUN
fnp-3806	1097	11	-	-	PUNCT
fnp-3806	1097	12	secretases	secretase	NOUN
fnp-3806	1097	13	,	,	PUNCT
fnp-3806	1097	14	the	the	DET
fnp-3806	1097	15	increment	increment	NOUN
fnp-3806	1097	16	of	of	ADP
fnp-3806	1097	17	local	local	ADJ
fnp-3806	1097	18	cholesterol	cholesterol	NOUN
fnp-3806	1097	19	facilitates	facilitate	VERB
fnp-3806	1097	20	the	the	DET
fnp-3806	1097	21	production	production	NOUN
fnp-3806	1097	22	of	of	ADP
fnp-3806	1097	23	β	β	NOUN
fnp-3806	1097	24	-	-	NOUN
fnp-3806	1097	25	amyloid	amyloid	NOUN
fnp-3806	1097	26	(	(	PUNCT
fnp-3806	1097	27	1397	1397	NUM
fnp-3806	1097	28	,	,	PUNCT
fnp-3806	1097	29	1398	1398	NUM
fnp-3806	1097	30	)	)	PUNCT
fnp-3806	1097	31	.	.	PUNCT
fnp-3806	1098	1	the	the	DET
fnp-3806	1098	2	lipid	lipid	NOUN
fnp-3806	1098	3	composition	composition	NOUN
fnp-3806	1098	4	of	of	ADP
fnp-3806	1098	5	membranes	membrane	NOUN
fnp-3806	1098	6	is	be	AUX
fnp-3806	1098	7	altered	alter	VERB
fnp-3806	1098	8	in	in	ADP
fnp-3806	1098	9	sad	sad	ADJ
fnp-3806	1098	10	.	.	PUNCT
fnp-3806	1099	1	β	β	X
fnp-3806	1099	2	-	-	PUNCT
fnp-3806	1099	3	amyloid	amyloid	ADJ
fnp-3806	1099	4	oligomers	oligomer	NOUN
fnp-3806	1099	5	and	and	CCONJ
fnp-3806	1099	6	peptides	peptide	NOUN
fnp-3806	1099	7	are	be	AUX
fnp-3806	1099	8	recruited	recruit	VERB
fnp-3806	1099	9	in	in	ADP
fnp-3806	1099	10	lipid	lipid	ADJ
fnp-3806	1099	11	rafts	raft	NOUN
fnp-3806	1099	12	(	(	PUNCT
fnp-3806	1099	13	1399	1399	NUM
fnp-3806	1099	14	-	-	SYM
fnp-3806	1099	15	1402	1402	NUM
fnp-3806	1099	16	)	)	PUNCT
fnp-3806	1099	17	.	.	PUNCT
fnp-3806	1100	1	altered	alter	VERB
fnp-3806	1100	2	lipid	lipid	NOUN
fnp-3806	1100	3	raft	raft	NOUN
fnp-3806	1100	4	composition	composition	NOUN
fnp-3806	1100	5	also	also	ADV
fnp-3806	1100	6	occurs	occur	VERB
fnp-3806	1100	7	in	in	ADP
fnp-3806	1100	8	app	app	PROPN
fnp-3806	1100	9	/	/	SYM
fnp-3806	1100	10	ps1	ps1	NOUN
fnp-3806	1100	11	double	double	ADJ
fnp-3806	1100	12	-	-	PUNCT
fnp-3806	1100	13	transgenic	transgenic	NOUN
fnp-3806	1100	14	mice	mouse	NOUN
fnp-3806	1100	15	,	,	PUNCT
fnp-3806	1100	16	a	a	DET
fnp-3806	1100	17	model	model	NOUN
fnp-3806	1100	18	of	of	ADP
fnp-3806	1100	19	familial	familial	ADJ
fnp-3806	1100	20	cerebral	cerebral	ADJ
fnp-3806	1100	21	β	β	NOUN
fnp-3806	1100	22	-	-	ADJ
fnp-3806	1100	23	amyloidopathy	amyloidopathy	ADJ
fnp-3806	1100	24	.	.	PUNCT
fnp-3806	1101	1	altered	alter	VERB
fnp-3806	1101	2	composition	composition	NOUN
fnp-3806	1101	3	of	of	ADP
fnp-3806	1101	4	lipid	lipid	ADJ
fnp-3806	1101	5	rafts	raft	NOUN
fnp-3806	1101	6	is	be	AUX
fnp-3806	1101	7	observed	observe	VERB
fnp-3806	1101	8	at	at	ADP
fnp-3806	1101	9	the	the	DET
fnp-3806	1101	10	age	age	NOUN
fnp-3806	1101	11	of	of	ADP
fnp-3806	1101	12	three	three	NUM
fnp-3806	1101	13	months	month	NOUN
fnp-3806	1101	14	in	in	ADP
fnp-3806	1101	15	parallel	parallel	NOUN
fnp-3806	1101	16	with	with	ADP
fnp-3806	1101	17	the	the	DET
fnp-3806	1101	18	appearance	appearance	NOUN
fnp-3806	1101	19	of	of	ADP
fnp-3806	1101	20	the	the	DET
fnp-3806	1101	21	first	first	ADJ
fnp-3806	1101	22	plaques	plaque	NOUN
fnp-3806	1101	23	in	in	ADP
fnp-3806	1101	24	these	these	DET
fnp-3806	1101	25	mice	mouse	NOUN
fnp-3806	1101	26	(	(	PUNCT
fnp-3806	1101	27	1403	1403	NUM
fnp-3806	1101	28	)	)	PUNCT
fnp-3806	1101	29	.	.	PUNCT
fnp-3806	1102	1	prion	prion	NOUN
fnp-3806	1102	2	protein	protein	NOUN
fnp-3806	1102	3	expression	expression	NOUN
fnp-3806	1102	4	in	in	ADP
fnp-3806	1102	5	sps	sps	PROPN
fnp-3806	1102	6	further	far	ADV
fnp-3806	1102	7	supports	support	VERB
fnp-3806	1102	8	alteration	alteration	NOUN
fnp-3806	1102	9	of	of	ADP
fnp-3806	1102	10	lipid	lipid	NOUN
fnp-3806	1102	11	raft	raft	NOUN
fnp-3806	1102	12	-	-	PUNCT
fnp-3806	1102	13	enriched	enrich	VERB
fnp-3806	1102	14	cell	cell	NOUN
fnp-3806	1102	15	membrane	membrane	NOUN
fnp-3806	1102	16	in	in	ADP
fnp-3806	1102	17	association	association	NOUN
fnp-3806	1102	18	with	with	ADP
fnp-3806	1102	19	β	β	NOUN
fnp-3806	1102	20	-	-	NOUN
fnp-3806	1102	21	amyloid	amyloid	ADJ
fnp-3806	1102	22	deposition	deposition	NOUN
fnp-3806	1102	23	at	at	ADP
fnp-3806	1102	24	advanced	advanced	ADJ
fnp-3806	1102	25	stages	stage	NOUN
fnp-3806	1102	26	of	of	ADP
fnp-3806	1102	27	sad	sad	ADJ
fnp-3806	1102	28	(	(	PUNCT
fnp-3806	1102	29	128	128	NUM
fnp-3806	1102	30	,	,	PUNCT
fnp-3806	1102	31	1404	1404	NUM
fnp-3806	1102	32	,	,	PUNCT
fnp-3806	1102	33	1405	1405	NUM
fnp-3806	1102	34	)	)	PUNCT
fnp-3806	1102	35	.	.	PUNCT
fnp-3806	1103	1	lipid	lipid	NOUN
fnp-3806	1103	2	raft	raft	NOUN
fnp-3806	1103	3	alteration	alteration	NOUN
fnp-3806	1103	4	in	in	ADP
fnp-3806	1103	5	ad	ad	NOUN
fnp-3806	1103	6	does	do	AUX
fnp-3806	1103	7	not	not	PART
fnp-3806	1103	8	occur	occur	VERB
fnp-3806	1103	9	abruptly	abruptly	ADV
fnp-3806	1103	10	.	.	PUNCT
fnp-3806	1104	1	the	the	DET
fnp-3806	1104	2	composition	composition	NOUN
fnp-3806	1104	3	of	of	ADP
fnp-3806	1104	4	lipid	lipid	ADJ
fnp-3806	1104	5	rafts	raft	NOUN
fnp-3806	1104	6	changes	change	NOUN
fnp-3806	1104	7	with	with	ADP
fnp-3806	1104	8	age	age	NOUN
fnp-3806	1104	9	in	in	ADP
fnp-3806	1104	10	a	a	DET
fnp-3806	1104	11	gender	gender	NOUN
fnp-3806	1104	12	-	-	PUNCT
fnp-3806	1104	13	dependent	dependent	ADJ
fnp-3806	1104	14	manner	manner	NOUN
fnp-3806	1104	15	.	.	PUNCT
fnp-3806	1105	1	the	the	DET
fnp-3806	1105	2	main	main	ADJ
fnp-3806	1105	3	changes	change	NOUN
fnp-3806	1105	4	affect	affect	VERB
fnp-3806	1105	5	levels	level	NOUN
fnp-3806	1105	6	of	of	ADP
fnp-3806	1105	7	plasmalogens	plasmalogen	NOUN
fnp-3806	1105	8	,	,	PUNCT
fnp-3806	1105	9	polyunsaturated	polyunsaturated	ADJ
fnp-3806	1105	10	fatty	fatty	NOUN
fnp-3806	1105	11	acids	acid	NOUN
fnp-3806	1105	12	(	(	PUNCT
fnp-3806	1105	13	especially	especially	ADV
fnp-3806	1105	14	dha	dha	PROPN
fnp-3806	1105	15	and	and	CCONJ
fnp-3806	1105	16	aa	aa	NOUN
fnp-3806	1105	17	)	)	PUNCT
fnp-3806	1105	18	,	,	PUNCT
fnp-3806	1105	19	total	total	ADJ
fnp-3806	1105	20	polar	polar	ADJ
fnp-3806	1105	21	lipids	lipid	NOUN
fnp-3806	1105	22	(	(	PUNCT
fnp-3806	1105	23	mainly	mainly	ADV
fnp-3806	1105	24	phosphatidylinositol	phosphatidylinositol	NOUN
fnp-3806	1105	25	,	,	PUNCT
fnp-3806	1105	26	sphingomyelin	sphingomyelin	NOUN
fnp-3806	1105	27	,	,	PUNCT
fnp-3806	1105	28	sulfatides	sulfatide	NOUN
fnp-3806	1105	29	,	,	PUNCT
fnp-3806	1105	30	and	and	CCONJ
fnp-3806	1105	31	cerebrosides	cerebroside	NOUN
fnp-3806	1105	32	)	)	PUNCT
fnp-3806	1105	33	,	,	PUNCT
fnp-3806	1105	34	and	and	CCONJ
fnp-3806	1105	35	total	total	ADJ
fnp-3806	1105	36	neutral	neutral	ADJ
fnp-3806	1105	37	lipids	lipid	NOUN
fnp-3806	1105	38	(	(	PUNCT
fnp-3806	1105	39	particularly	particularly	ADV
fnp-3806	1105	40	cholesterol	cholesterol	NOUN
fnp-3806	1105	41	and	and	CCONJ
fnp-3806	1105	42	sterol	sterol	NOUN
fnp-3806	1105	43	esters	ester	NOUN
fnp-3806	1105	44	)	)	PUNCT
fnp-3806	1105	45	(	(	PUNCT
fnp-3806	1105	46	1406	1406	NUM
fnp-3806	1105	47	)	)	PUNCT
fnp-3806	1105	48	.	.	PUNCT
fnp-3806	1106	1	importantly	importantly	ADV
fnp-3806	1106	2	,	,	PUNCT
fnp-3806	1106	3	the	the	DET
fnp-3806	1106	4	lipid	lipid	NOUN
fnp-3806	1106	5	composition	composition	NOUN
fnp-3806	1106	6	of	of	ADP
fnp-3806	1106	7	lipid	lipid	ADJ
fnp-3806	1106	8	rafts	raft	NOUN
fnp-3806	1106	9	in	in	ADP
fnp-3806	1106	10	the	the	DET
fnp-3806	1106	11	entorhinal	entorhinal	ADJ
fnp-3806	1106	12	cortex	cortex	NOUN
fnp-3806	1106	13	and	and	CCONJ
fnp-3806	1106	14	frontal	frontal	ADJ
fnp-3806	1106	15	cortex	cortex	NOUN
fnp-3806	1106	16	,	,	PUNCT
fnp-3806	1106	17	but	but	CCONJ
fnp-3806	1106	18	not	not	PART
fnp-3806	1106	19	the	the	DET
fnp-3806	1106	20	cerebellum	cerebellum	NOUN
fnp-3806	1106	21	,	,	PUNCT
fnp-3806	1106	22	is	be	AUX
fnp-3806	1106	23	already	already	ADV
fnp-3806	1106	24	altered	alter	VERB
fnp-3806	1106	25	in	in	ADP
fnp-3806	1106	26	human	human	ADJ
fnp-3806	1106	27	brain	brain	NOUN
fnp-3806	1106	28	at	at	ADP
fnp-3806	1106	29	nft	nft	PROPN
fnp-3806	1106	30	stages	stage	NOUN
fnp-3806	1106	31	i	i	PROPN
fnp-3806	1106	32	-	-	PUNCT
fnp-3806	1106	33	ii	ii	PROPN
fnp-3806	1106	34	without	without	ADP
fnp-3806	1106	35	β	β	NOUN
fnp-3806	1106	36	-	-	ADJ
fnp-3806	1106	37	amyloid	amyloid	ADJ
fnp-3806	1106	38	deposits	deposit	NOUN
fnp-3806	1106	39	;	;	PUNCT
fnp-3806	1106	40	lipid	lipid	NOUN
fnp-3806	1106	41	rafts	raft	NOUN
fnp-3806	1106	42	at	at	ADP
fnp-3806	1106	43	these	these	DET
fnp-3806	1106	44	stages	stage	NOUN
fnp-3806	1106	45	display	display	VERB
fnp-3806	1106	46	higher	high	ADJ
fnp-3806	1106	47	anisotropy	anisotropy	NOUN
fnp-3806	1106	48	,	,	PUNCT
fnp-3806	1106	49	indicating	indicate	VERB
fnp-3806	1106	50	that	that	SCONJ
fnp-3806	1106	51	lipid	lipid	NOUN
fnp-3806	1106	52	changes	change	NOUN
fnp-3806	1106	53	in	in	ADP
fnp-3806	1106	54	brain	brain	NOUN
fnp-3806	1106	55	at	at	ADP
fnp-3806	1106	56	nft	nft	PROPN
fnp-3806	1106	57	stages	stage	NOUN
fnp-3806	1106	58	i	i	PROPN
fnp-3806	1106	59	-	-	PUNCT
fnp-3806	1106	60	ii	ii	NOUN
fnp-3806	1106	61	increase	increase	VERB
fnp-3806	1106	62	membrane	membrane	NOUN
fnp-3806	1106	63	order	order	NOUN
fnp-3806	1106	64	and	and	CCONJ
fnp-3806	1106	65	viscosity	viscosity	NOUN
fnp-3806	1106	66	in	in	ADP
fnp-3806	1106	67	these	these	DET
fnp-3806	1106	68	domains	domain	NOUN
fnp-3806	1106	69	(	(	PUNCT
fnp-3806	1106	70	1407	1407	NUM
fnp-3806	1106	71	)	)	PUNCT
fnp-3806	1106	72	.	.	PUNCT
fnp-3806	1107	1	among	among	ADP
fnp-3806	1107	2	other	other	ADJ
fnp-3806	1107	3	alterations	alteration	NOUN
fnp-3806	1107	4	,	,	PUNCT
fnp-3806	1107	5	the	the	DET
fnp-3806	1107	6	structure	structure	NOUN
fnp-3806	1107	7	of	of	ADP
fnp-3806	1107	8	lipid	lipid	ADJ
fnp-3806	1107	9	rafts	raft	NOUN
fnp-3806	1107	10	at	at	ADP
fnp-3806	1107	11	stages	stage	NOUN
fnp-3806	1107	12	i	i	PROPN
fnp-3806	1107	13	-	-	PUNCT
fnp-3806	1107	14	ii	ii	PROPN
fnp-3806	1107	15	is	be	AUX
fnp-3806	1107	16	associated	associate	VERB
fnp-3806	1107	17	with	with	ADP
fnp-3806	1107	18	increased	increase	VERB
fnp-3806	1107	19	bace1	bace1	NOUN
fnp-3806	1107	20	/	/	SYM
fnp-3806	1107	21	aβpp	aβpp	NOUN
fnp-3806	1107	22	interaction	interaction	NOUN
fnp-3806	1107	23	(	(	PUNCT
fnp-3806	1107	24	1408	1408	NUM
fnp-3806	1107	25	)	)	PUNCT
fnp-3806	1107	26	.	.	PUNCT
fnp-3806	1108	1	there	there	PRON
fnp-3806	1108	2	is	be	VERB
fnp-3806	1108	3	also	also	ADV
fnp-3806	1108	4	a	a	DET
fnp-3806	1108	5	close	close	ADJ
fnp-3806	1108	6	functional	functional	ADJ
fnp-3806	1108	7	relationship	relationship	NOUN
fnp-3806	1108	8	between	between	ADP
fnp-3806	1108	9	cytoskeletal	cytoskeletal	ADJ
fnp-3806	1108	10	proteins	protein	NOUN
fnp-3806	1108	11	and	and	CCONJ
fnp-3806	1108	12	cell	cell	NOUN
fnp-3806	1108	13	membranes	membrane	NOUN
fnp-3806	1108	14	through	through	ADP
fnp-3806	1108	15	protein	protein	NOUN
fnp-3806	1108	16	-	-	PUNCT
fnp-3806	1108	17	protein	protein	NOUN
fnp-3806	1108	18	interactions	interaction	NOUN
fnp-3806	1108	19	,	,	PUNCT
fnp-3806	1108	20	electrostatic	electrostatic	ADJ
fnp-3806	1108	21	interactions	interaction	NOUN
fnp-3806	1108	22	with	with	ADP
fnp-3806	1108	23	lipid	lipid	ADJ
fnp-3806	1108	24	membranes	membrane	NOUN
fnp-3806	1108	25	,	,	PUNCT
fnp-3806	1108	26	and	and	CCONJ
fnp-3806	1108	27	lipid	lipid	NOUN
fnp-3806	1108	28	tails	tail	NOUN
fnp-3806	1108	29	.	.	PUNCT
fnp-3806	1109	1	these	these	DET
fnp-3806	1109	2	complementary	complementary	ADJ
fnp-3806	1109	3	interactions	interaction	NOUN
fnp-3806	1109	4	are	be	AUX
fnp-3806	1109	5	ruined	ruin	VERB
fnp-3806	1109	6	once	once	SCONJ
fnp-3806	1109	7	one	one	NUM
fnp-3806	1109	8	of	of	ADP
fnp-3806	1109	9	the	the	DET
fnp-3806	1109	10	components	component	NOUN
fnp-3806	1109	11	is	be	AUX
fnp-3806	1109	12	altered	alter	VERB
fnp-3806	1109	13	.	.	PUNCT
fnp-3806	1110	1	altered	altered	ADJ
fnp-3806	1110	2	composition	composition	NOUN
fnp-3806	1110	3	of	of	ADP
fnp-3806	1110	4	lipid	lipid	ADJ
fnp-3806	1110	5	rafts	raft	NOUN
fnp-3806	1110	6	and	and	CCONJ
fnp-3806	1110	7	membrane	membrane	NOUN
fnp-3806	1110	8	proteins	protein	NOUN
fnp-3806	1110	9	increases	increase	NOUN
fnp-3806	1110	10	aβ	aβ	ADP
fnp-3806	1110	11	pathways	pathway	NOUN
fnp-3806	1110	12	and	and	CCONJ
fnp-3806	1110	13	tau	tau	PROPN
fnp-3806	1110	14	fibrilisation	fibrilisation	NOUN
fnp-3806	1110	15	.	.	PUNCT
fnp-3806	1111	1	at	at	ADP
fnp-3806	1111	2	the	the	DET
fnp-3806	1111	3	same	same	ADJ
fnp-3806	1111	4	time	time	NOUN
fnp-3806	1111	5	,	,	PUNCT
fnp-3806	1111	6	tau	tau	PROPN
fnp-3806	1111	7	monomers	monomer	NOUN
fnp-3806	1111	8	and	and	CCONJ
fnp-3806	1111	9	β	β	NOUN
fnp-3806	1111	10	-	-	NOUN
fnp-3806	1111	11	sheet	sheet	NOUN
fnp-3806	1111	12	-	-	PUNCT
fnp-3806	1111	13	rich	rich	ADJ
fnp-3806	1111	14	tau	tau	PROPN
fnp-3806	1111	15	structures	structure	NOUN
fnp-3806	1111	16	disrupt	disrupt	VERB
fnp-3806	1111	17	cell	cell	NOUN
fnp-3806	1111	18	membranes	membrane	NOUN
fnp-3806	1111	19	(	(	PUNCT
fnp-3806	1111	20	156	156	NUM
fnp-3806	1111	21	,	,	PUNCT
fnp-3806	1111	22	212	212	NUM
fnp-3806	1111	23	,	,	PUNCT
fnp-3806	1111	24	1389	1389	NUM
fnp-3806	1111	25	,	,	PUNCT
fnp-3806	1111	26	1409	1409	NUM
fnp-3806	1111	27	-	-	SYM
fnp-3806	1111	28	1413	1413	NUM
fnp-3806	1111	29	)	)	PUNCT
fnp-3806	1111	30	.	.	PUNCT
fnp-3806	1112	1	tau	tau	PROPN
fnp-3806	1112	2	connections	connection	NOUN
fnp-3806	1112	3	with	with	ADP
fnp-3806	1112	4	lipid	lipid	ADJ
fnp-3806	1112	5	tails	tail	NOUN
fnp-3806	1112	6	depend	depend	VERB
fnp-3806	1112	7	on	on	ADP
fnp-3806	1112	8	electrostatic	electrostatic	ADJ
fnp-3806	1112	9	interactions	interaction	NOUN
fnp-3806	1112	10	and	and	CCONJ
fnp-3806	1112	11	phospholipid	phospholipid	NOUN
fnp-3806	1112	12	composition	composition	NOUN
fnp-3806	1112	13	with	with	ADP
fnp-3806	1112	14	high	high	ADJ
fnp-3806	1112	15	affinity	affinity	NOUN
fnp-3806	1112	16	for	for	ADP
fnp-3806	1112	17	anionic	anionic	ADJ
fnp-3806	1112	18	lipids	lipid	NOUN
fnp-3806	1112	19	and	and	CCONJ
fnp-3806	1112	20	anionic	anionic	ADJ
fnp-3806	1112	21	vesicles	vesicle	NOUN
fnp-3806	1112	22	(	(	PUNCT
fnp-3806	1112	23	1414	1414	NUM
fnp-3806	1112	24	,	,	PUNCT
fnp-3806	1112	25	1416	1416	NUM
fnp-3806	1112	26	)	)	PUNCT
fnp-3806	1112	27	.	.	PUNCT
fnp-3806	1113	1	tau	tau	PROPN
fnp-3806	1113	2	monomers	monomer	NOUN
fnp-3806	1113	3	may	may	AUX
fnp-3806	1113	4	concentrate	concentrate	VERB
fnp-3806	1113	5	at	at	ADP
fnp-3806	1113	6	the	the	DET
fnp-3806	1113	7	membrane	membrane	NOUN
fnp-3806	1113	8	and	and	CCONJ
fnp-3806	1113	9	form	form	NOUN
fnp-3806	1113	10	oligomers	oligomer	NOUN
fnp-3806	1113	11	and	and	CCONJ
fnp-3806	1113	12	fibrils	fibril	NOUN
fnp-3806	1113	13	under	under	ADP
fnp-3806	1113	14	pathological	pathological	ADJ
fnp-3806	1113	15	conditions	condition	NOUN
fnp-3806	1113	16	.	.	PUNCT
fnp-3806	1114	1	these	these	DET
fnp-3806	1114	2	β	β	NOUN
fnp-3806	1114	3	-	-	ADJ
fnp-3806	1114	4	sheet	sheet	NOUN
fnp-3806	1114	5	-	-	PUNCT
fnp-3806	1114	6	rich	rich	ADJ
fnp-3806	1114	7	tau	tau	PROPN
fnp-3806	1114	8	structures	structure	NOUN
fnp-3806	1114	9	are	be	AUX
fnp-3806	1114	10	capable	capable	ADJ
fnp-3806	1114	11	of	of	ADP
fnp-3806	1114	12	disrupting	disrupt	VERB
fnp-3806	1114	13	membrane	membrane	NOUN
fnp-3806	1114	14	organization	organization	NOUN
fnp-3806	1114	15	and	and	CCONJ
fnp-3806	1114	16	function	function	NOUN
fnp-3806	1114	17	(	(	PUNCT
fnp-3806	1114	18	212	212	NUM
fnp-3806	1114	19	)	)	PUNCT
fnp-3806	1114	20	.	.	PUNCT
fnp-3806	1115	1	deposition	deposition	NOUN
fnp-3806	1115	2	of	of	ADP
fnp-3806	1115	3	abnormal	abnormal	ADJ
fnp-3806	1115	4	tau	tau	NOUN
fnp-3806	1115	5	at	at	ADP
fnp-3806	1115	6	the	the	DET
fnp-3806	1115	7	preand	preand	NOUN
fnp-3806	1115	8	post	post	ADJ
fnp-3806	1115	9	-	-	ADJ
fnp-3806	1115	10	synaptic	synaptic	ADJ
fnp-3806	1115	11	membranes	membrane	NOUN
fnp-3806	1115	12	may	may	AUX
fnp-3806	1115	13	appear	appear	VERB
fnp-3806	1115	14	prior	prior	ADV
fnp-3806	1115	15	to	to	ADP
fnp-3806	1115	16	the	the	DET
fnp-3806	1115	17	appearance	appearance	NOUN
fnp-3806	1115	18	of	of	ADP
fnp-3806	1115	19	nfts	nft	NOUN
fnp-3806	1115	20	,	,	PUNCT
fnp-3806	1115	21	and	and	CCONJ
fnp-3806	1115	22	it	it	PRON
fnp-3806	1115	23	contributes	contribute	VERB
fnp-3806	1115	24	to	to	ADP
fnp-3806	1115	25	early	early	ADJ
fnp-3806	1115	26	synaptic	synaptic	ADJ
fnp-3806	1115	27	dysfunction	dysfunction	NOUN
fnp-3806	1115	28	(	(	PUNCT
fnp-3806	1115	29	409	409	NUM
fnp-3806	1115	30	)	)	PUNCT
fnp-3806	1115	31	.	.	PUNCT
fnp-3806	1116	1	conversely	conversely	ADV
fnp-3806	1116	2	,	,	PUNCT
fnp-3806	1116	3	there	there	PRON
fnp-3806	1116	4	is	be	VERB
fnp-3806	1116	5	also	also	ADV
fnp-3806	1116	6	the	the	DET
fnp-3806	1116	7	possibility	possibility	NOUN
fnp-3806	1116	8	that	that	SCONJ
fnp-3806	1116	9	alterations	alteration	NOUN
fnp-3806	1116	10	at	at	ADP
fnp-3806	1116	11	the	the	DET
fnp-3806	1116	12	cell	cell	NOUN
fnp-3806	1116	13	membrane	membrane	NOUN
fnp-3806	1116	14	involving	involve	VERB
fnp-3806	1116	15	the	the	DET
fnp-3806	1116	16	lipid	lipid	NOUN
fnp-3806	1116	17	composition	composition	NOUN
fnp-3806	1116	18	and	and	CCONJ
fnp-3806	1116	19	post	post	ADJ
fnp-3806	1116	20	-	-	ADJ
fnp-3806	1116	21	translational	translational	ADJ
fnp-3806	1116	22	modifications	modification	NOUN
fnp-3806	1116	23	of	of	ADP
fnp-3806	1116	24	membrane	membrane	ADJ
fnp-3806	1116	25	proteins	protein	NOUN
fnp-3806	1116	26	trigger	trigger	NOUN
fnp-3806	1116	27	abnormal	abnormal	ADJ
fnp-3806	1116	28	phosphorylation	phosphorylation	NOUN
fnp-3806	1116	29	of	of	ADP
fnp-3806	1116	30	tau	tau	PROPN
fnp-3806	1116	31	and	and	CCONJ
fnp-3806	1116	32	induce	induce	VERB
fnp-3806	1116	33	formation	formation	NOUN
fnp-3806	1116	34	of	of	ADP
fnp-3806	1116	35	tau	tau	PROPN
fnp-3806	1116	36	fibrils	fibril	NOUN
fnp-3806	1116	37	(	(	PUNCT
fnp-3806	1116	38	1417	1417	NUM
fnp-3806	1116	39	)	)	PUNCT
fnp-3806	1116	40	(	(	PUNCT
fnp-3806	1116	41	see	see	VERB
fnp-3806	1116	42	section	section	NOUN
fnp-3806	1116	43	21h	21h	PROPN
fnp-3806	1116	44	)	)	PUNCT
fnp-3806	1116	45	.	.	PUNCT
fnp-3806	1117	1	plasma	plasma	NOUN
fnp-3806	1117	2	membrane	membrane	NOUN
fnp-3806	1117	3	specializations	specialization	NOUN
fnp-3806	1117	4	containing	contain	VERB
fnp-3806	1117	5	caveolin	caveolin	NOUN
fnp-3806	1117	6	are	be	AUX
fnp-3806	1117	7	invaginated	invaginate	VERB
fnp-3806	1117	8	and	and	CCONJ
fnp-3806	1117	9	form	form	NOUN
fnp-3806	1117	10	caveolae	caveolae	NOUN
fnp-3806	1117	11	which	which	PRON
fnp-3806	1117	12	are	be	AUX
fnp-3806	1117	13	closely	closely	ADV
fnp-3806	1117	14	related	relate	VERB
fnp-3806	1117	15	to	to	ADP
fnp-3806	1117	16	lipid	lipid	ADJ
fnp-3806	1117	17	rafts	raft	NOUN
fnp-3806	1117	18	(	(	PUNCT
fnp-3806	1117	19	1418	1418	NUM
fnp-3806	1117	20	)	)	PUNCT
fnp-3806	1117	21	.	.	PUNCT
fnp-3806	1118	1	caveolae	caveolae	NOUN
fnp-3806	1118	2	in	in	ADP
fnp-3806	1118	3	sad	sad	ADJ
fnp-3806	1118	4	participate	participate	NOUN
fnp-3806	1118	5	in	in	ADP
fnp-3806	1118	6	a	a	DET
fnp-3806	1118	7	wide	wide	ADJ
fnp-3806	1118	8	number	number	NOUN
fnp-3806	1118	9	of	of	ADP
fnp-3806	1118	10	processes	process	NOUN
fnp-3806	1118	11	including	include	VERB
fnp-3806	1118	12	internalization	internalization	NOUN
fnp-3806	1118	13	of	of	ADP
fnp-3806	1118	14	tau	tau	PROPN
fnp-3806	1118	15	oligomers	oligomer	NOUN
fnp-3806	1118	16	and	and	CCONJ
fnp-3806	1118	17	β	β	NOUN
fnp-3806	1118	18	-	-	ADJ
fnp-3806	1118	19	amyloid	amyloid	ADJ
fnp-3806	1118	20	metabolism	metabolism	NOUN
fnp-3806	1118	21	(	(	PUNCT
fnp-3806	1118	22	1419	1419	NUM
fnp-3806	1118	23	-	-	SYM
fnp-3806	1118	24	1421	1421	NUM
fnp-3806	1118	25	)	)	PUNCT
fnp-3806	1118	26	.	.	PUNCT
fnp-3806	1119	1	other	other	ADJ
fnp-3806	1119	2	factors	factor	NOUN
fnp-3806	1119	3	influence	influence	VERB
fnp-3806	1119	4	membrane	membrane	NOUN
fnp-3806	1119	5	damage	damage	NOUN
fnp-3806	1119	6	,	,	PUNCT
fnp-3806	1119	7	in	in	ADP
fnp-3806	1119	8	particular	particular	ADJ
fnp-3806	1119	9	,	,	PUNCT
fnp-3806	1119	10	microglial	microglial	ADJ
fnp-3806	1119	11	pro	pro	ADJ
fnp-3806	1119	12	-	-	ADJ
fnp-3806	1119	13	inflammatory	inflammatory	ADJ
fnp-3806	1119	14	mediators	mediator	NOUN
fnp-3806	1119	15	generating	generate	VERB
fnp-3806	1119	16	membrane	membrane	NOUN
fnp-3806	1119	17	damages	damage	NOUN
fnp-3806	1119	18	(	(	PUNCT
fnp-3806	1119	19	1422	1422	NUM
fnp-3806	1119	20	)	)	PUNCT
fnp-3806	1119	21	.	.	PUNCT
fnp-3806	1120	1	22d	22d	NOUN
fnp-3806	1120	2	.	.	PUNCT
fnp-3806	1121	1	mitochondria	mitochondria	PROPN
fnp-3806	1121	2	mitochondrial	mitochondrial	ADJ
fnp-3806	1121	3	alterations	alteration	NOUN
fnp-3806	1121	4	were	be	AUX
fnp-3806	1121	5	identified	identify	VERB
fnp-3806	1121	6	in	in	ADP
fnp-3806	1121	7	the	the	DET
fnp-3806	1121	8	pioneering	pioneering	ADJ
fnp-3806	1121	9	ultrastructural	ultrastructural	ADJ
fnp-3806	1121	10	research	research	NOUN
fnp-3806	1121	11	of	of	ADP
fnp-3806	1121	12	ad	ad	NOUN
fnp-3806	1121	13	and	and	CCONJ
fnp-3806	1121	14	were	be	AUX
fnp-3806	1121	15	later	later	ADV
fnp-3806	1121	16	sustained	sustain	VERB
fnp-3806	1121	17	by	by	ADP
fnp-3806	1121	18	functional	functional	ADJ
fnp-3806	1121	19	studies	study	NOUN
fnp-3806	1121	20	(	(	PUNCT
fnp-3806	1121	21	1423	1423	NUM
fnp-3806	1121	22	-	-	SYM
fnp-3806	1121	23	1427	1427	NUM
fnp-3806	1121	24	)	)	PUNCT
fnp-3806	1121	25	.	.	PUNCT
fnp-3806	1122	1	mitochondrial	mitochondrial	ADJ
fnp-3806	1122	2	alterations	alteration	NOUN
fnp-3806	1122	3	in	in	ADP
fnp-3806	1122	4	sad	sad	ADJ
fnp-3806	1122	5	led	lead	VERB
fnp-3806	1122	6	to	to	ADP
fnp-3806	1122	7	the	the	DET
fnp-3806	1122	8	formulation	formulation	NOUN
fnp-3806	1122	9	of	of	ADP
fnp-3806	1122	10	the	the	DET
fnp-3806	1122	11	“	"	PUNCT
fnp-3806	1122	12	mitochondrial	mitochondrial	ADJ
fnp-3806	1122	13	cascade	cascade	NOUN
fnp-3806	1122	14	hypothesis	hypothesis	NOUN
fnp-3806	1122	15	”	"	PUNCT
fnp-3806	1122	16	,	,	PUNCT
fnp-3806	1122	17	proposing	propose	VERB
fnp-3806	1122	18	that	that	SCONJ
fnp-3806	1122	19	mitochondrial	mitochondrial	ADJ
fnp-3806	1122	20	alterations	alteration	NOUN
fnp-3806	1122	21	and	and	CCONJ
fnp-3806	1122	22	failed	fail	VERB
fnp-3806	1122	23	energy	energy	NOUN
fnp-3806	1122	24	metabolism	metabolism	NOUN
fnp-3806	1122	25	trigger	trigger	NOUN
fnp-3806	1122	26	sad	sad	ADJ
fnp-3806	1122	27	(	(	PUNCT
fnp-3806	1122	28	1428	1428	NUM
fnp-3806	1122	29	,	,	PUNCT
fnp-3806	1122	30	1429	1429	NUM
fnp-3806	1122	31	)	)	PUNCT
fnp-3806	1122	32	.	.	PUNCT
fnp-3806	1123	1	recent	recent	ADJ
fnp-3806	1123	2	reviews	review	NOUN
fnp-3806	1123	3	have	have	AUX
fnp-3806	1123	4	stressed	stress	VERB
fnp-3806	1123	5	the	the	DET
fnp-3806	1123	6	importance	importance	NOUN
fnp-3806	1123	7	of	of	ADP
fnp-3806	1123	8	mitochondrial	mitochondrial	ADJ
fnp-3806	1123	9	failure	failure	NOUN
fnp-3806	1123	10	in	in	ADP
fnp-3806	1123	11	the	the	DET
fnp-3806	1123	12	pathogenesis	pathogenesis	NOUN
fnp-3806	1123	13	of	of	ADP
fnp-3806	1123	14	ad	ad	NOUN
fnp-3806	1123	15	(	(	PUNCT
fnp-3806	1123	16	1430	1430	NUM
fnp-3806	1123	17	-	-	SYM
fnp-3806	1123	18	1432	1432	NUM
fnp-3806	1123	19	)	)	PUNCT
fnp-3806	1123	20	.	.	PUNCT
fnp-3806	1124	1	functional	functional	ADJ
fnp-3806	1124	2	defects	defect	NOUN
fnp-3806	1124	3	in	in	ADP
fnp-3806	1124	4	atp	atp	NOUN
fnp-3806	1124	5	-	-	PUNCT
fnp-3806	1124	6	synthase	synthase	NOUN
fnp-3806	1124	7	are	be	AUX
fnp-3806	1124	8	considered	consider	VERB
fnp-3806	1124	9	a	a	DET
fnp-3806	1124	10	main	main	ADJ
fnp-3806	1124	11	contributory	contributory	NOUN
fnp-3806	1124	12	factor	factor	NOUN
fnp-3806	1124	13	to	to	PART
fnp-3806	1124	14	explain	explain	VERB
fnp-3806	1124	15	failure	failure	NOUN
fnp-3806	1124	16	of	of	ADP
fnp-3806	1124	17	energy	energy	NOUN
fnp-3806	1124	18	production	production	NOUN
fnp-3806	1124	19	in	in	ADP
fnp-3806	1124	20	mitochondria	mitochondria	PROPN
fnp-3806	1124	21	(	(	PUNCT
fnp-3806	1124	22	1433	1433	NUM
fnp-3806	1124	23	)	)	PUNCT
fnp-3806	1124	24	.	.	PUNCT
fnp-3806	1125	1	other	other	ADJ
fnp-3806	1125	2	studies	study	NOUN
fnp-3806	1125	3	have	have	AUX
fnp-3806	1125	4	stressed	stress	VERB
fnp-3806	1125	5	the	the	DET
fnp-3806	1125	6	impairment	impairment	NOUN
fnp-3806	1125	7	of	of	ADP
fnp-3806	1125	8	complex	complex	ADJ
fnp-3806	1125	9	i	i	PRON
fnp-3806	1125	10	in	in	ADP
fnp-3806	1125	11	mild	mild	ADJ
fnp-3806	1125	12	cases	case	NOUN
fnp-3806	1125	13	of	of	ADP
fnp-3806	1125	14	ad	ad	NOUN
fnp-3806	1125	15	(	(	PUNCT
fnp-3806	1125	16	1434	1434	NUM
fnp-3806	1125	17	)	)	PUNCT
fnp-3806	1125	18	.	.	PUNCT
fnp-3806	1126	1	besides	besides	SCONJ
fnp-3806	1126	2	energy	energy	NOUN
fnp-3806	1126	3	metabolism	metabolism	NOUN
fnp-3806	1126	4	deterioration	deterioration	NOUN
fnp-3806	1126	5	,	,	PUNCT
fnp-3806	1126	6	abnormal	abnormal	ADJ
fnp-3806	1126	7	mitochondrial	mitochondrial	ADJ
fnp-3806	1126	8	function	function	NOUN
fnp-3806	1126	9	also	also	ADV
fnp-3806	1126	10	causes	cause	VERB
fnp-3806	1126	11	increased	increased	ADJ
fnp-3806	1126	12	production	production	NOUN
fnp-3806	1126	13	of	of	ADP
fnp-3806	1126	14	ros	ros	PROPN
fnp-3806	1126	15	(	(	PUNCT
fnp-3806	1126	16	1435	1435	NUM
fnp-3806	1126	17	-	-	SYM
fnp-3806	1126	18	1437	1437	NUM
fnp-3806	1126	19	)	)	PUNCT
fnp-3806	1126	20	.	.	PUNCT
fnp-3806	1127	1	mitochondrial	mitochondrial	ADJ
fnp-3806	1127	2	atp	atp	NOUN
fnp-3806	1127	3	-	-	PUNCT
fnp-3806	1127	4	synthase	synthase	NOUN
fnp-3806	1127	5	is	be	AUX
fnp-3806	1127	6	a	a	DET
fnp-3806	1127	7	target	target	NOUN
fnp-3806	1127	8	of	of	ADP
fnp-3806	1127	9	oxidative	oxidative	ADJ
fnp-3806	1127	10	damage	damage	NOUN
fnp-3806	1127	11	in	in	ADP
fnp-3806	1127	12	the	the	DET
fnp-3806	1127	13	entorhinal	entorhinal	ADJ
fnp-3806	1127	14	cortex	cortex	NOUN
fnp-3806	1127	15	at	at	ADP
fnp-3806	1127	16	stages	stage	NOUN
fnp-3806	1127	17	i	i	PROPN
fnp-3806	1127	18	-	-	PUNCT
fnp-3806	1127	19	ii	ii	PROPN
fnp-3806	1127	20	of	of	ADP
fnp-3806	1127	21	nft	nft	PROPN
fnp-3806	1127	22	pathology	pathology	PROPN
fnp-3806	1127	23	;	;	PUNCT
fnp-3806	1127	24	total	total	ADJ
fnp-3806	1127	25	levels	level	NOUN
fnp-3806	1127	26	of	of	ADP
fnp-3806	1127	27	atp	atp	NOUN
fnp-3806	1127	28	-	-	PUNCT
fnp-3806	1127	29	synthase	synthase	NOUN
fnp-3806	1127	30	are	be	AUX
fnp-3806	1127	31	preserved	preserve	VERB
fnp-3806	1127	32	but	but	CCONJ
fnp-3806	1127	33	atpase	atpase	PROPN
fnp-3806	1127	34	function	function	NOUN
fnp-3806	1127	35	is	be	AUX
fnp-3806	1127	36	impaired	impair	VERB
fnp-3806	1127	37	(	(	PUNCT
fnp-3806	1127	38	1438	1438	NUM
fnp-3806	1127	39	)	)	PUNCT
fnp-3806	1127	40	.	.	PUNCT
fnp-3806	1128	1	altered	alter	VERB
fnp-3806	1128	2	mitochondrial	mitochondrial	ADJ
fnp-3806	1128	3	dna	dna	PROPN
fnp-3806	1128	4	methylation	methylation	NOUN
fnp-3806	1128	5	is	be	AUX
fnp-3806	1128	6	manifested	manifest	VERB
fnp-3806	1128	7	in	in	ADP
fnp-3806	1128	8	the	the	DET
fnp-3806	1128	9	entorhinal	entorhinal	ADJ
fnp-3806	1128	10	cortex	cortex	NOUN
fnp-3806	1128	11	at	at	ADP
fnp-3806	1128	12	stages	stage	NOUN
fnp-3806	1128	13	i	i	PROPN
fnp-3806	1128	14	-	-	PUNCT
fnp-3806	1128	15	ii	ii	PROPN
fnp-3806	1128	16	of	of	ADP
fnp-3806	1128	17	nft	nft	PROPN
fnp-3806	1128	18	pathology	pathology	PROPN
fnp-3806	1128	19	and	and	CCONJ
fnp-3806	1128	20	advances	advance	VERB
fnp-3806	1128	21	with	with	ADP
fnp-3806	1128	22	disease	disease	NOUN
fnp-3806	1128	23	progression	progression	NOUN
fnp-3806	1128	24	(	(	PUNCT
fnp-3806	1128	25	1028	1028	NUM
fnp-3806	1128	26	)	)	PUNCT
fnp-3806	1128	27	.	.	PUNCT
fnp-3806	1129	1	increased	increase	VERB
fnp-3806	1129	2	mitochondrial	mitochondrial	ADJ
fnp-3806	1129	3	5	5	NUM
fnp-3806	1129	4	-	-	PUNCT
fnp-3806	1129	5	methylcytosine	methylcytosine	ADJ
fnp-3806	1129	6	levels	level	NOUN
fnp-3806	1129	7	are	be	AUX
fnp-3806	1129	8	found	find	VERB
fnp-3806	1129	9	in	in	ADP
fnp-3806	1129	10	the	the	DET
fnp-3806	1129	11	d	d	PROPN
fnp-3806	1129	12	-	-	PUNCT
fnp-3806	1129	13	loop	loop	NOUN
fnp-3806	1129	14	region	region	NOUN
fnp-3806	1129	15	of	of	ADP
fnp-3806	1129	16	mtdna	mtdna	NOUN
fnp-3806	1129	17	in	in	ADP
fnp-3806	1129	18	the	the	DET
fnp-3806	1129	19	entorhinal	entorhinal	ADJ
fnp-3806	1129	20	cortex	cortex	NOUN
fnp-3806	1129	21	.	.	PUNCT
fnp-3806	1130	1	interestingly	interestingly	ADV
fnp-3806	1130	2	,	,	PUNCT
fnp-3806	1130	3	this	this	DET
fnp-3806	1130	4	region	region	NOUN
fnp-3806	1130	5	shows	show	VERB
fnp-3806	1130	6	a	a	DET
fnp-3806	1130	7	dynamic	dynamic	ADJ
fnp-3806	1130	8	pattern	pattern	NOUN
fnp-3806	1130	9	in	in	ADP
fnp-3806	1130	10	the	the	DET
fnp-3806	1130	11	content	content	NOUN
fnp-3806	1130	12	of	of	ADP
fnp-3806	1130	13	mitochondrial	mitochondrial	ADJ
fnp-3806	1130	14	5	5	NUM
fnp-3806	1130	15	-	-	PUNCT
fnp-3806	1130	16	methylcytosine	methylcytosine	NOUN
fnp-3806	1130	17	in	in	ADP
fnp-3806	1130	18	app	app	PROPN
fnp-3806	1130	19	/	/	SYM
fnp-3806	1130	20	ps1	ps1	NOUN
fnp-3806	1130	21	transgenic	transgenic	NOUN
fnp-3806	1130	22	mice	mouse	NOUN
fnp-3806	1130	23	in	in	ADP
fnp-3806	1130	24	parallel	parallel	NOUN
fnp-3806	1130	25	with	with	ADP
fnp-3806	1130	26	the	the	DET
fnp-3806	1130	27	progression	progression	NOUN
fnp-3806	1130	28	of	of	ADP
fnp-3806	1130	29	β	β	NOUN
fnp-3806	1130	30	-	-	ADJ
fnp-3806	1130	31	amyloid	amyloid	ADJ
fnp-3806	1130	32	pathology	pathology	NOUN
fnp-3806	1130	33	in	in	ADP
fnp-3806	1130	34	these	these	DET
fnp-3806	1130	35	mice	mouse	NOUN
fnp-3806	1130	36	(	(	PUNCT
fnp-3806	1130	37	1028	1028	NUM
fnp-3806	1130	38	)	)	PUNCT
fnp-3806	1130	39	.	.	PUNCT
fnp-3806	1131	1	aβ	aβ	PRON
fnp-3806	1131	2	deposits	deposit	NOUN
fnp-3806	1131	3	have	have	AUX
fnp-3806	1131	4	been	be	AUX
fnp-3806	1131	5	considered	consider	VERB
fnp-3806	1131	6	a	a	DET
fnp-3806	1131	7	main	main	ADJ
fnp-3806	1131	8	cause	cause	NOUN
fnp-3806	1131	9	of	of	ADP
fnp-3806	1131	10	mitochondrial	mitochondrial	ADJ
fnp-3806	1131	11	dysfunction	dysfunction	NOUN
fnp-3806	1131	12	in	in	ADP
fnp-3806	1131	13	ad	ad	NOUN
fnp-3806	1131	14	(	(	PUNCT
fnp-3806	1131	15	1439	1439	NUM
fnp-3806	1131	16	)	)	PUNCT
fnp-3806	1131	17	.	.	PUNCT
fnp-3806	1132	1	additionally	additionally	ADV
fnp-3806	1132	2	,	,	PUNCT
fnp-3806	1132	3	mitochondrial	mitochondrial	ADJ
fnp-3806	1132	4	abnormalities	abnormality	NOUN
fnp-3806	1132	5	are	be	AUX
fnp-3806	1132	6	observed	observe	VERB
fnp-3806	1132	7	in	in	ADP
fnp-3806	1132	8	tau	tau	PROPN
fnp-3806	1132	9	transgenic	transgenic	NOUN
fnp-3806	1132	10	mice	mouse	NOUN
fnp-3806	1132	11	(	(	PUNCT
fnp-3806	1132	12	1440	1440	NUM
fnp-3806	1132	13	)	)	PUNCT
fnp-3806	1132	14	.	.	PUNCT
fnp-3806	1133	1	aβ	aβ	PRON
fnp-3806	1133	2	and	and	CCONJ
fnp-3806	1133	3	tau	tau	PROPN
fnp-3806	1133	4	pathology	pathology	NOUN
fnp-3806	1133	5	have	have	VERB
fnp-3806	1133	6	synergistic	synergistic	ADJ
fnp-3806	1133	7	effects	effect	NOUN
fnp-3806	1133	8	on	on	ADP
fnp-3806	1133	9	mitochondria	mitochondria	NOUN
fnp-3806	1133	10	in	in	ADP
fnp-3806	1133	11	triple	triple	ADJ
fnp-3806	1133	12	transgenic	transgenic	NOUN
fnp-3806	1133	13	mice	mouse	NOUN
fnp-3806	1133	14	(	(	PUNCT
fnp-3806	1133	15	1441	1441	NUM
fnp-3806	1133	16	)	)	PUNCT
fnp-3806	1133	17	.	.	PUNCT
fnp-3806	1134	1	it	it	PRON
fnp-3806	1134	2	has	have	AUX
fnp-3806	1134	3	been	be	AUX
fnp-3806	1134	4	proposed	propose	VERB
fnp-3806	1134	5	that	that	SCONJ
fnp-3806	1134	6	there	there	PRON
fnp-3806	1134	7	are	be	VERB
fnp-3806	1134	8	mitochondrial	mitochondrial	ADJ
fnp-3806	1134	9	links	link	NOUN
fnp-3806	1134	10	between	between	ADP
fnp-3806	1134	11	brain	brain	NOUN
fnp-3806	1134	12	aging	aging	NOUN
fnp-3806	1134	13	and	and	CCONJ
fnp-3806	1134	14	ad	ad	NOUN
fnp-3806	1134	15	(	(	PUNCT
fnp-3806	1134	16	1442	1442	NUM
fnp-3806	1134	17	)	)	PUNCT
fnp-3806	1134	18	.	.	PUNCT
fnp-3806	1135	1	the	the	DET
fnp-3806	1135	2	mitochondria	mitochondria	NOUN
fnp-3806	1135	3	-	-	PUNCT
fnp-3806	1135	4	associated	associate	VERB
fnp-3806	1135	5	lipid	lipid	NOUN
fnp-3806	1135	6	raft	raft	NOUN
fnp-3806	1135	7	-	-	PUNCT
fnp-3806	1135	8	domain	domain	NOUN
fnp-3806	1135	9	of	of	ADP
fnp-3806	1135	10	the	the	DET
fnp-3806	1135	11	er	er	INTJ
fnp-3806	1135	12	in	in	ADP
fnp-3806	1135	13	close	close	ADJ
fnp-3806	1135	14	contact	contact	NOUN
fnp-3806	1135	15	with	with	ADP
fnp-3806	1135	16	the	the	DET
fnp-3806	1135	17	mitochondria	mitochondria	NOUN
fnp-3806	1135	18	,	,	PUNCT
fnp-3806	1135	19	called	call	VERB
fnp-3806	1135	20	mam	mam	NOUN
fnp-3806	1135	21	(	(	PUNCT
fnp-3806	1135	22	mitochondria	mitochondria	NOUN
fnp-3806	1135	23	-	-	PUNCT
fnp-3806	1135	24	associated	associate	VERB
fnp-3806	1135	25	er	er	INTJ
fnp-3806	1135	26	membrane	membrane	NOUN
fnp-3806	1135	27	)	)	PUNCT
fnp-3806	1135	28	,	,	PUNCT
fnp-3806	1135	29	facilitates	facilitate	VERB
fnp-3806	1135	30	functional	functional	ADJ
fnp-3806	1135	31	and	and	CCONJ
fnp-3806	1135	32	biochemical	biochemical	ADJ
fnp-3806	1135	33	interaction	interaction	NOUN
fnp-3806	1135	34	between	between	ADP
fnp-3806	1135	35	these	these	DET
fnp-3806	1135	36	structures	structure	NOUN
fnp-3806	1135	37	,	,	PUNCT
fnp-3806	1135	38	mainly	mainly	ADV
fnp-3806	1135	39	linked	link	VERB
fnp-3806	1135	40	to	to	ADP
fnp-3806	1135	41	metabolism	metabolism	NOUN
fnp-3806	1135	42	of	of	ADP
fnp-3806	1135	43	the	the	DET
fnp-3806	1135	44	cholesterol	cholesterol	NOUN
fnp-3806	1135	45	,	,	PUNCT
fnp-3806	1135	46	phospholipids	phospholipid	NOUN
fnp-3806	1135	47	,	,	PUNCT
fnp-3806	1135	48	glucose	glucose	NOUN
fnp-3806	1135	49	,	,	PUNCT
fnp-3806	1135	50	fatty	fatty	NOUN
fnp-3806	1135	51	acids	acid	NOUN
fnp-3806	1135	52	,	,	PUNCT
fnp-3806	1135	53	and	and	CCONJ
fnp-3806	1135	54	calcium	calcium	NOUN
fnp-3806	1135	55	signaling	signal	VERB
fnp-3806	1135	56	(	(	PUNCT
fnp-3806	1135	57	1443	1443	NUM
fnp-3806	1135	58	,	,	PUNCT
fnp-3806	1135	59	1444	1444	NUM
fnp-3806	1135	60	)	)	PUNCT
fnp-3806	1135	61	.	.	PUNCT
fnp-3806	1136	1	mam	mam	PROPN
fnp-3806	1136	2	functions	function	NOUN
fnp-3806	1136	3	are	be	AUX
fnp-3806	1136	4	altered	alter	VERB
fnp-3806	1136	5	at	at	ADP
fnp-3806	1136	6	early	early	ADJ
fnp-3806	1136	7	stages	stage	NOUN
fnp-3806	1136	8	of	of	ADP
fnp-3806	1136	9	sad	sad	ADJ
fnp-3806	1136	10	(	(	PUNCT
fnp-3806	1136	11	1445	1445	NUM
fnp-3806	1136	12	,	,	PUNCT
fnp-3806	1136	13	1446	1446	NUM
fnp-3806	1136	14	)	)	PUNCT
fnp-3806	1136	15	,	,	PUNCT
fnp-3806	1136	16	thus	thus	ADV
fnp-3806	1136	17	prompting	prompt	VERB
fnp-3806	1136	18	the	the	DET
fnp-3806	1136	19	“	"	PUNCT
fnp-3806	1136	20	mam	mam	ADJ
fnp-3806	1136	21	-	-	PUNCT
fnp-3806	1136	22	hypothesis	hypothesis	NOUN
fnp-3806	1136	23	”	"	PUNCT
fnp-3806	1136	24	as	as	ADP
fnp-3806	1136	25	a	a	DET
fnp-3806	1136	26	determinant	determinant	NOUN
fnp-3806	1136	27	in	in	ADP
fnp-3806	1136	28	the	the	DET
fnp-3806	1136	29	pathogenesis	pathogenesis	NOUN
fnp-3806	1136	30	of	of	ADP
fnp-3806	1136	31	sad	sad	ADJ
fnp-3806	1136	32	(	(	PUNCT
fnp-3806	1136	33	1447	1447	NUM
fnp-3806	1136	34	)	)	PUNCT
fnp-3806	1136	35	.	.	PUNCT
fnp-3806	1137	1	there	there	PRON
fnp-3806	1137	2	is	be	VERB
fnp-3806	1137	3	growing	grow	VERB
fnp-3806	1137	4	evidence	evidence	NOUN
fnp-3806	1137	5	of	of	ADP
fnp-3806	1137	6	impaired	impaired	ADJ
fnp-3806	1137	7	physical	physical	ADJ
fnp-3806	1137	8	and	and	CCONJ
fnp-3806	1137	9	proteome	proteome	NOUN
fnp-3806	1137	10	crosstalk	crosstalk	NOUN
fnp-3806	1137	11	between	between	ADP
fnp-3806	1137	12	er	er	INTJ
fnp-3806	1137	13	and	and	CCONJ
fnp-3806	1137	14	mitochondria	mitochondria	NOUN
fnp-3806	1137	15	in	in	ADP
fnp-3806	1137	16	sad	sad	ADJ
fnp-3806	1137	17	(	(	PUNCT
fnp-3806	1137	18	1444	1444	NUM
fnp-3806	1137	19	)	)	PUNCT
fnp-3806	1137	20	.	.	PUNCT
fnp-3806	1138	1	22e	22e	NOUN
fnp-3806	1138	2	.	.	PUNCT
fnp-3806	1139	1	oxidative	oxidative	ADJ
fnp-3806	1139	2	stress	stress	NOUN
fnp-3806	1139	3	damage	damage	NOUN
fnp-3806	1139	4	the	the	DET
fnp-3806	1139	5	mitochondria	mitochondria	ADJ
fnp-3806	1139	6	respiratory	respiratory	ADJ
fnp-3806	1139	7	chain	chain	NOUN
fnp-3806	1139	8	generates	generate	VERB
fnp-3806	1139	9	ros	ros	PROPN
fnp-3806	1139	10	which	which	PRON
fnp-3806	1139	11	participate	participate	VERB
fnp-3806	1139	12	in	in	ADP
fnp-3806	1139	13	cell	cell	NOUN
fnp-3806	1139	14	signalling	signal	VERB
fnp-3806	1139	15	under	under	ADP
fnp-3806	1139	16	physiological	physiological	ADJ
fnp-3806	1139	17	conditions	condition	NOUN
fnp-3806	1139	18	.	.	PUNCT
fnp-3806	1140	1	peroxisomes	peroxisome	NOUN
fnp-3806	1140	2	,	,	PUNCT
fnp-3806	1140	3	er	er	INTJ
fnp-3806	1140	4	,	,	PUNCT
fnp-3806	1140	5	microsomes	microsomes	PROPN
fnp-3806	1140	6	,	,	PUNCT
fnp-3806	1140	7	nucleus	nucleus	NOUN
fnp-3806	1140	8	and	and	CCONJ
fnp-3806	1140	9	plasma	plasma	NOUN
fnp-3806	1140	10	membrane	membrane	NOUN
fnp-3806	1140	11	are	be	AUX
fnp-3806	1140	12	potential	potential	ADJ
fnp-3806	1140	13	sources	source	NOUN
fnp-3806	1140	14	of	of	ADP
fnp-3806	1140	15	ros	ros	PROPN
fnp-3806	1140	16	.	.	PUNCT
fnp-3806	1141	1	excess	excess	ADJ
fnp-3806	1141	2	production	production	NOUN
fnp-3806	1141	3	of	of	ADP
fnp-3806	1141	4	ros	ros	PROPN
fnp-3806	1141	5	and	and	CCONJ
fnp-3806	1141	6	deficient	deficient	ADJ
fnp-3806	1141	7	anti	anti	ADJ
fnp-3806	1141	8	-	-	ADJ
fnp-3806	1141	9	oxidant	oxidant	ADJ
fnp-3806	1141	10	responses	response	NOUN
fnp-3806	1141	11	lead	lead	VERB
fnp-3806	1141	12	to	to	PART
fnp-3806	1141	13	oxidative	oxidative	VERB
fnp-3806	1141	14	stress	stress	NOUN
fnp-3806	1141	15	damage	damage	NOUN
fnp-3806	1141	16	to	to	ADP
fnp-3806	1141	17	dna	dna	PROPN
fnp-3806	1141	18	,	,	PUNCT
fnp-3806	1141	19	rna	rna	NOUN
fnp-3806	1141	20	,	,	PUNCT
fnp-3806	1141	21	carbohydrates	carbohydrate	NOUN
fnp-3806	1141	22	,	,	PUNCT
fnp-3806	1141	23	lipids	lipid	NOUN
fnp-3806	1141	24	,	,	PUNCT
fnp-3806	1141	25	and	and	CCONJ
fnp-3806	1141	26	proteins	protein	NOUN
fnp-3806	1141	27	.	.	PUNCT
fnp-3806	1142	1	ion	ion	NOUN
fnp-3806	1142	2	-	-	PUNCT
fnp-3806	1142	3	catalyzed	catalyze	VERB
fnp-3806	1142	4	oxidation	oxidation	NOUN
fnp-3806	1142	5	of	of	ADP
fnp-3806	1142	6	some	some	DET
fnp-3806	1142	7	amino	amino	NOUN
fnp-3806	1142	8	acid	acid	NOUN
fnp-3806	1142	9	residues	residue	NOUN
fnp-3806	1142	10	may	may	AUX
fnp-3806	1142	11	result	result	VERB
fnp-3806	1142	12	in	in	ADP
fnp-3806	1142	13	the	the	DET
fnp-3806	1142	14	production	production	NOUN
fnp-3806	1142	15	of	of	ADP
fnp-3806	1142	16	carbonyl	carbonyl	NOUN
fnp-3806	1142	17	derivatives	derivative	NOUN
fnp-3806	1142	18	such	such	ADJ
fnp-3806	1142	19	as	as	ADP
fnp-3806	1142	20	glutamic	glutamic	ADJ
fnp-3806	1142	21	semialdehyde	semialdehyde	NOUN
fnp-3806	1142	22	and	and	CCONJ
fnp-3806	1142	23	aminoadipic	aminoadipic	NOUN
fnp-3806	1142	24	semialdehyde	semialdehyde	NOUN
fnp-3806	1142	25	.	.	PUNCT
fnp-3806	1143	1	in	in	ADP
fnp-3806	1143	2	addition	addition	NOUN
fnp-3806	1143	3	to	to	ADP
fnp-3806	1143	4	direct	direct	ADJ
fnp-3806	1143	5	effects	effect	NOUN
fnp-3806	1143	6	,	,	PUNCT
fnp-3806	1143	7	oxidative	oxidative	ADJ
fnp-3806	1143	8	modifications	modification	NOUN
fnp-3806	1143	9	may	may	AUX
fnp-3806	1143	10	induce	induce	VERB
fnp-3806	1143	11	the	the	DET
fnp-3806	1143	12	production	production	NOUN
fnp-3806	1143	13	of	of	ADP
fnp-3806	1143	14	reactive	reactive	ADJ
fnp-3806	1143	15	carbonyl	carbonyl	NOUN
fnp-3806	1143	16	species	specie	NOUN
fnp-3806	1143	17	such	such	ADJ
fnp-3806	1143	18	as	as	ADP
fnp-3806	1143	19	glyoxal	glyoxal	NOUN
fnp-3806	1143	20	,	,	PUNCT
fnp-3806	1143	21	glycoaldehyde	glycoaldehyde	NOUN
fnp-3806	1143	22	,	,	PUNCT
fnp-3806	1143	23	methylglyoxal	methylglyoxal	PROPN
fnp-3806	1143	24	,	,	PUNCT
fnp-3806	1143	25	malondialdehyde	malondialdehyde	NOUN
fnp-3806	1143	26	(	(	PUNCT
fnp-3806	1143	27	mda	mda	PROPN
fnp-3806	1143	28	)	)	PUNCT
fnp-3806	1143	29	,	,	PUNCT
fnp-3806	1143	30	and	and	CCONJ
fnp-3806	1143	31	4	4	NUM
fnp-3806	1143	32	-	-	PUNCT
fnp-3806	1143	33	hydroxynonenal	hydroxynonenal	NOUN
fnp-3806	1143	34	(	(	PUNCT
fnp-3806	1143	35	hne	hne	NOUN
fnp-3806	1143	36	)	)	PUNCT
fnp-3806	1143	37	,	,	PUNCT
fnp-3806	1143	38	derived	derive	VERB
fnp-3806	1143	39	from	from	ADP
fnp-3806	1143	40	the	the	DET
fnp-3806	1143	41	oxidation	oxidation	NOUN
fnp-3806	1143	42	of	of	ADP
fnp-3806	1143	43	carbohydrates	carbohydrate	NOUN
fnp-3806	1143	44	and	and	CCONJ
fnp-3806	1143	45	lipids	lipid	NOUN
fnp-3806	1143	46	.	.	PUNCT
fnp-3806	1144	1	carbonyl	carbonyl	NOUN
fnp-3806	1144	2	species	specie	NOUN
fnp-3806	1144	3	react	react	VERB
fnp-3806	1144	4	with	with	ADP
fnp-3806	1144	5	lysine	lysine	NOUN
fnp-3806	1144	6	,	,	PUNCT
fnp-3806	1144	7	arginine	arginine	NOUN
fnp-3806	1144	8	,	,	PUNCT
fnp-3806	1144	9	and	and	CCONJ
fnp-3806	1144	10	cysteine	cysteine	NOUN
fnp-3806	1144	11	residues	residue	NOUN
fnp-3806	1144	12	,	,	PUNCT
fnp-3806	1144	13	leading	lead	VERB
fnp-3806	1144	14	to	to	ADP
fnp-3806	1144	15	the	the	DET
fnp-3806	1144	16	formation	formation	NOUN
fnp-3806	1144	17	of	of	ADP
fnp-3806	1144	18	advanced	advanced	ADJ
fnp-3806	1144	19	glycation	glycation	NOUN
fnp-3806	1144	20	and	and	CCONJ
fnp-3806	1144	21	lipoxidation	lipoxidation	NOUN
fnp-3806	1144	22	end	end	NOUN
fnp-3806	1144	23	-	-	PUNCT
fnp-3806	1144	24	products	product	NOUN
fnp-3806	1144	25	(	(	PUNCT
fnp-3806	1144	26	age	age	NOUN
fnp-3806	1144	27	/	/	SYM
fnp-3806	1144	28	ales	ale	NOUN
fnp-3806	1144	29	)	)	PUNCT
fnp-3806	1144	30	in	in	ADP
fnp-3806	1144	31	proteins	protein	NOUN
fnp-3806	1144	32	.	.	PUNCT
fnp-3806	1145	1	typical	typical	ADJ
fnp-3806	1145	2	ages	age	NOUN
fnp-3806	1145	3	/	/	SYM
fnp-3806	1145	4	ales	ales	PROPN
fnp-3806	1145	5	adducts	adduct	NOUN
fnp-3806	1145	6	are	be	AUX
fnp-3806	1145	7	carboxymethyl	carboxymethyl	NOUN
fnp-3806	1145	8	-	-	PUNCT
fnp-3806	1145	9	lysine	lysine	NOUN
fnp-3806	1145	10	(	(	PUNCT
fnp-3806	1145	11	cml	cml	PROPN
fnp-3806	1145	12	)	)	PUNCT
fnp-3806	1145	13	,	,	PUNCT
fnp-3806	1145	14	carboxyethyl	carboxyethyl	NOUN
fnp-3806	1145	15	-	-	PUNCT
fnp-3806	1145	16	lysine	lysine	NOUN
fnp-3806	1145	17	(	(	PUNCT
fnp-3806	1145	18	cel	cel	PROPN
fnp-3806	1145	19	)	)	PUNCT
fnp-3806	1145	20	,	,	PUNCT
fnp-3806	1145	21	and	and	CCONJ
fnp-3806	1145	22	mda	mda	PROPN
fnp-3806	1145	23	-	-	PUNCT
fnp-3806	1145	24	lysine	lysine	NOUN
fnp-3806	1145	25	(	(	PUNCT
fnp-3806	1145	26	mdal	mdal	NOUN
fnp-3806	1145	27	)	)	PUNCT
fnp-3806	1145	28	,	,	PUNCT
fnp-3806	1145	29	among	among	ADP
fnp-3806	1145	30	others	other	NOUN
fnp-3806	1145	31	(	(	PUNCT
fnp-3806	1145	32	1357	1357	NUM
fnp-3806	1145	33	,	,	PUNCT
fnp-3806	1145	34	1373	1373	NUM
fnp-3806	1145	35	,	,	PUNCT
fnp-3806	1145	36	1381	1381	NUM
fnp-3806	1145	37	,	,	PUNCT
fnp-3806	1145	38	1448	1448	NUM
fnp-3806	1145	39	,	,	PUNCT
fnp-3806	1145	40	1449	1449	NUM
fnp-3806	1145	41	)	)	PUNCT
fnp-3806	1145	42	.	.	PUNCT
fnp-3806	1146	1	regarding	regard	VERB
fnp-3806	1146	2	rns	rn	NOUN
fnp-3806	1146	3	,	,	PUNCT
fnp-3806	1146	4	nitric	nitric	ADJ
fnp-3806	1146	5	oxide	oxide	NOUN
fnp-3806	1146	6	damage	damage	NOUN
fnp-3806	1146	7	to	to	ADP
fnp-3806	1146	8	thiols	thiol	NOUN
fnp-3806	1146	9	,	,	PUNCT
fnp-3806	1146	10	amines	amine	NOUN
fnp-3806	1146	11	,	,	PUNCT
fnp-3806	1146	12	and	and	CCONJ
fnp-3806	1146	13	hydroxyls	hydroxyls	ADJ
fnp-3806	1146	14	leads	lead	VERB
fnp-3806	1146	15	to	to	ADP
fnp-3806	1146	16	nitrosative	nitrosative	ADJ
fnp-3806	1146	17	damage	damage	NOUN
fnp-3806	1146	18	.	.	PUNCT
fnp-3806	1147	1	reactions	reaction	NOUN
fnp-3806	1147	2	with	with	ADP
fnp-3806	1147	3	rns	rn	NOUN
fnp-3806	1147	4	lead	lead	VERB
fnp-3806	1147	5	to	to	ADP
fnp-3806	1147	6	the	the	DET
fnp-3806	1147	7	formation	formation	NOUN
fnp-3806	1147	8	of	of	ADP
fnp-3806	1147	9	3	3	NUM
fnp-3806	1147	10	-	-	PUNCT
fnp-3806	1147	11	nitrotyrosine	nitrotyrosine	NOUN
fnp-3806	1147	12	(	(	PUNCT
fnp-3806	1147	13	nitration	nitration	NOUN
fnp-3806	1147	14	)	)	PUNCT
fnp-3806	1147	15	and	and	CCONJ
fnp-3806	1147	16	to	to	ADP
fnp-3806	1147	17	oxidation	oxidation	NOUN
fnp-3806	1147	18	of	of	ADP
fnp-3806	1147	19	distinct	distinct	ADJ
fnp-3806	1147	20	substrates	substrate	NOUN
fnp-3806	1147	21	.	.	PUNCT
fnp-3806	1148	1	reactive	reactive	ADJ
fnp-3806	1148	2	peroxinitrite	peroxinitrite	PROPN
fnp-3806	1148	3	is	be	AUX
fnp-3806	1148	4	able	able	ADJ
fnp-3806	1148	5	to	to	PART
fnp-3806	1148	6	nitrate	nitrate	VERB
fnp-3806	1148	7	tyrosine	tyrosine	NOUN
fnp-3806	1148	8	residues	residue	NOUN
fnp-3806	1148	9	and	and	CCONJ
fnp-3806	1148	10	to	to	PART
fnp-3806	1148	11	oxidize	oxidize	VERB
fnp-3806	1148	12	methionine	methionine	NOUN
fnp-3806	1148	13	residues	residue	NOUN
fnp-3806	1148	14	of	of	ADP
fnp-3806	1148	15	proteins	protein	NOUN
fnp-3806	1148	16	(	(	PUNCT
fnp-3806	1148	17	1450	1450	NUM
fnp-3806	1148	18	)	)	PUNCT
fnp-3806	1148	19	.	.	PUNCT
fnp-3806	1149	1	oxidative	oxidative	ADJ
fnp-3806	1149	2	stress	stress	NOUN
fnp-3806	1149	3	damage	damage	NOUN
fnp-3806	1149	4	is	be	AUX
fnp-3806	1149	5	a	a	DET
fnp-3806	1149	6	major	major	ADJ
fnp-3806	1149	7	component	component	NOUN
fnp-3806	1149	8	of	of	ADP
fnp-3806	1149	9	brain	brain	NOUN
fnp-3806	1149	10	aging	aging	NOUN
fnp-3806	1149	11	.	.	PUNCT
fnp-3806	1150	1	protein	protein	NOUN
fnp-3806	1150	2	oxidative	oxidative	ADJ
fnp-3806	1150	3	and	and	CCONJ
fnp-3806	1150	4	glycoxidative	glycoxidative	ADJ
fnp-3806	1150	5	damage	damage	NOUN
fnp-3806	1150	6	significantly	significantly	ADV
fnp-3806	1150	7	increases	increase	VERB
fnp-3806	1150	8	with	with	ADP
fnp-3806	1150	9	age	age	NOUN
fnp-3806	1150	10	;	;	PUNCT
fnp-3806	1150	11	60	60	NUM
fnp-3806	1150	12	years	year	NOUN
fnp-3806	1150	13	of	of	ADP
fnp-3806	1150	14	age	age	NOUN
fnp-3806	1150	15	is	be	AUX
fnp-3806	1150	16	the	the	DET
fnp-3806	1150	17	breakpoint	breakpoint	NOUN
fnp-3806	1150	18	of	of	ADP
fnp-3806	1150	19	human	human	ADJ
fnp-3806	1150	20	frontal	frontal	ADJ
fnp-3806	1150	21	cortex	cortex	NOUN
fnp-3806	1150	22	aging	aging	NOUN
fnp-3806	1150	23	(	(	PUNCT
fnp-3806	1150	24	1451	1451	NUM
fnp-3806	1150	25	)	)	PUNCT
fnp-3806	1150	26	.	.	PUNCT
fnp-3806	1151	1	oxidative	oxidative	ADJ
fnp-3806	1151	2	stress	stress	NOUN
fnp-3806	1151	3	damage	damage	NOUN
fnp-3806	1151	4	in	in	ADP
fnp-3806	1151	5	the	the	DET
fnp-3806	1151	6	aging	age	VERB
fnp-3806	1151	7	brain	brain	NOUN
fnp-3806	1151	8	is	be	AUX
fnp-3806	1151	9	regionand	regionand	NOUN
fnp-3806	1151	10	age	age	NOUN
fnp-3806	1151	11	-	-	PUNCT
fnp-3806	1151	12	dependent	dependent	ADJ
fnp-3806	1151	13	(	(	PUNCT
fnp-3806	1151	14	1452	1452	NUM
fnp-3806	1151	15	)	)	PUNCT
fnp-3806	1151	16	.	.	PUNCT
fnp-3806	1152	1	regional	regional	ADJ
fnp-3806	1152	2	vulnerability	vulnerability	NOUN
fnp-3806	1152	3	to	to	ADP
fnp-3806	1152	4	neurodegeneration	neurodegeneration	NOUN
fnp-3806	1152	5	based	base	VERB
fnp-3806	1152	6	on	on	ADP
fnp-3806	1152	7	energy	energy	NOUN
fnp-3806	1152	8	demands	demand	NOUN
fnp-3806	1152	9	,	,	PUNCT
fnp-3806	1152	10	oxidative	oxidative	ADJ
fnp-3806	1152	11	stress	stress	NOUN
fnp-3806	1152	12	,	,	PUNCT
fnp-3806	1152	13	and	and	CCONJ
fnp-3806	1152	14	other	other	ADJ
fnp-3806	1152	15	metabolic	metabolic	NOUN
fnp-3806	1152	16	factors	factor	NOUN
fnp-3806	1152	17	can	can	AUX
fnp-3806	1152	18	predict	predict	VERB
fnp-3806	1152	19	neurodegeneration	neurodegeneration	NOUN
fnp-3806	1152	20	(	(	PUNCT
fnp-3806	1152	21	1453	1453	NUM
fnp-3806	1152	22	)	)	PUNCT
fnp-3806	1152	23	.	.	PUNCT
fnp-3806	1153	1	for	for	ADP
fnp-3806	1153	2	example	example	NOUN
fnp-3806	1153	3	,	,	PUNCT
fnp-3806	1153	4	lower	low	ADJ
fnp-3806	1153	5	energy	energy	NOUN
fnp-3806	1153	6	demand	demand	NOUN
fnp-3806	1153	7	,	,	PUNCT
fnp-3806	1153	8	lower	low	ADJ
fnp-3806	1153	9	mitochondrial	mitochondrial	ADJ
fnp-3806	1153	10	stress	stress	NOUN
fnp-3806	1153	11	,	,	PUNCT
fnp-3806	1153	12	and	and	CCONJ
fnp-3806	1153	13	one	one	NUM
fnp-3806	1153	14	-	-	PUNCT
fnp-3806	1153	15	carbon	carbon	NOUN
fnp-3806	1153	16	metabolism	metabolism	NOUN
fnp-3806	1153	17	(	(	PUNCT
fnp-3806	1153	18	particularly	particularly	ADV
fnp-3806	1153	19	restricted	restrict	VERB
fnp-3806	1153	20	to	to	ADP
fnp-3806	1153	21	the	the	DET
fnp-3806	1153	22	methionine	methionine	NOUN
fnp-3806	1153	23	cycle	cycle	NOUN
fnp-3806	1153	24	)	)	PUNCT
fnp-3806	1153	25	,	,	PUNCT
fnp-3806	1153	26	together	together	ADV
fnp-3806	1153	27	with	with	ADP
fnp-3806	1153	28	lower	low	ADJ
fnp-3806	1153	29	target	target	NOUN
fnp-3806	1153	30	of	of	ADP
fnp-3806	1153	31	rapamycin	rapamycin	NOUN
fnp-3806	1153	32	(	(	PUNCT
fnp-3806	1153	33	tor	tor	NOUN
fnp-3806	1153	34	)	)	PUNCT
fnp-3806	1153	35	signaling	signaling	ADJ
fnp-3806	1153	36	and	and	CCONJ
fnp-3806	1153	37	better	well	ADJ
fnp-3806	1153	38	antioxidant	antioxidant	ADJ
fnp-3806	1153	39	capacity	capacity	NOUN
fnp-3806	1153	40	,	,	PUNCT
fnp-3806	1153	41	occur	occur	VERB
fnp-3806	1153	42	in	in	ADP
fnp-3806	1153	43	the	the	DET
fnp-3806	1153	44	frontal	frontal	ADJ
fnp-3806	1153	45	cortex	cortex	NOUN
fnp-3806	1153	46	compared	compare	VERB
fnp-3806	1153	47	with	with	ADP
fnp-3806	1153	48	the	the	DET
fnp-3806	1153	49	entorhinal	entorhinal	ADJ
fnp-3806	1153	50	cortex	cortex	NOUN
fnp-3806	1153	51	and	and	CCONJ
fnp-3806	1153	52	the	the	DET
fnp-3806	1153	53	hippocampus	hippocampus	NOUN
fnp-3806	1153	54	.	.	PUNCT
fnp-3806	1154	1	these	these	DET
fnp-3806	1154	2	differences	difference	NOUN
fnp-3806	1154	3	suggest	suggest	VERB
fnp-3806	1154	4	that	that	SCONJ
fnp-3806	1154	5	the	the	DET
fnp-3806	1154	6	frontal	frontal	ADJ
fnp-3806	1154	7	cortex	cortex	NOUN
fnp-3806	1154	8	is	be	AUX
fnp-3806	1154	9	relatively	relatively	ADV
fnp-3806	1154	10	resistant	resistant	ADJ
fnp-3806	1154	11	to	to	ADP
fnp-3806	1154	12	stress	stress	NOUN
fnp-3806	1154	13	compared	compare	VERB
fnp-3806	1154	14	to	to	ADP
fnp-3806	1154	15	the	the	DET
fnp-3806	1154	16	entorhinal	entorhinal	ADJ
fnp-3806	1154	17	cortex	cortex	NOUN
fnp-3806	1154	18	and	and	CCONJ
fnp-3806	1154	19	hippocampus	hippocampus	NOUN
fnp-3806	1154	20	(	(	PUNCT
fnp-3806	1154	21	1454	1454	NUM
fnp-3806	1154	22	)	)	PUNCT
fnp-3806	1154	23	.	.	PUNCT
fnp-3806	1155	1	however	however	ADV
fnp-3806	1155	2	,	,	PUNCT
fnp-3806	1155	3	this	this	DET
fnp-3806	1155	4	hypothesis	hypothesis	NOUN
fnp-3806	1155	5	does	do	AUX
fnp-3806	1155	6	not	not	PART
fnp-3806	1155	7	apply	apply	VERB
fnp-3806	1155	8	universally	universally	ADV
fnp-3806	1155	9	when	when	SCONJ
fnp-3806	1155	10	assessing	assess	VERB
fnp-3806	1155	11	different	different	ADJ
fnp-3806	1155	12	brain	brain	NOUN
fnp-3806	1155	13	regions	region	NOUN
fnp-3806	1155	14	of	of	ADP
fnp-3806	1155	15	individual	individual	ADJ
fnp-3806	1155	16	brains	brain	NOUN
fnp-3806	1155	17	in	in	ADP
fnp-3806	1155	18	parallel	parallel	NOUN
fnp-3806	1155	19	(	(	PUNCT
fnp-3806	1155	20	1455	1455	NUM
fnp-3806	1155	21	)	)	PUNCT
fnp-3806	1155	22	.	.	PUNCT
fnp-3806	1156	1	the	the	DET
fnp-3806	1156	2	results	result	NOUN
fnp-3806	1156	3	are	be	AUX
fnp-3806	1156	4	more	more	ADV
fnp-3806	1156	5	complex	complex	ADJ
fnp-3806	1156	6	and	and	CCONJ
fnp-3806	1156	7	their	their	PRON
fnp-3806	1156	8	interpretation	interpretation	NOUN
fnp-3806	1156	9	is	be	AUX
fnp-3806	1156	10	more	more	ADV
fnp-3806	1156	11	difficult	difficult	ADJ
fnp-3806	1156	12	.	.	PUNCT
fnp-3806	1157	1	vulnerable	vulnerable	ADJ
fnp-3806	1157	2	cortical	cortical	ADJ
fnp-3806	1157	3	and	and	CCONJ
fnp-3806	1157	4	diencephalic	diencephalic	ADJ
fnp-3806	1157	5	regions	region	NOUN
fnp-3806	1157	6	are	be	AUX
fnp-3806	1157	7	in	in	ADP
fnp-3806	1157	8	fact	fact	NOUN
fnp-3806	1157	9	more	more	ADV
fnp-3806	1157	10	resistant	resistant	ADJ
fnp-3806	1157	11	to	to	ADP
fnp-3806	1157	12	degeneration	degeneration	NOUN
fnp-3806	1157	13	in	in	ADP
fnp-3806	1157	14	aging	age	VERB
fnp-3806	1157	15	(	(	PUNCT
fnp-3806	1157	16	1455	1455	NUM
fnp-3806	1157	17	)	)	PUNCT
fnp-3806	1157	18	.	.	PUNCT
fnp-3806	1158	1	however	however	ADV
fnp-3806	1158	2	,	,	PUNCT
fnp-3806	1158	3	differences	difference	NOUN
fnp-3806	1158	4	in	in	ADP
fnp-3806	1158	5	vulnerability	vulnerability	NOUN
fnp-3806	1158	6	to	to	ADP
fnp-3806	1158	7	protein	protein	NOUN
fnp-3806	1158	8	oxidation	oxidation	NOUN
fnp-3806	1158	9	are	be	AUX
fnp-3806	1158	10	dependent	dependent	ADJ
fnp-3806	1158	11	on	on	ADP
fnp-3806	1158	12	the	the	DET
fnp-3806	1158	13	subcellular	subcellular	ADJ
fnp-3806	1158	14	localization	localization	NOUN
fnp-3806	1158	15	,	,	PUNCT
fnp-3806	1158	16	secondary	secondary	ADJ
fnp-3806	1158	17	structure	structure	NOUN
fnp-3806	1158	18	,	,	PUNCT
fnp-3806	1158	19	and	and	CCONJ
fnp-3806	1158	20	external	external	ADJ
fnp-3806	1158	21	exposition	exposition	NOUN
fnp-3806	1158	22	of	of	ADP
fnp-3806	1158	23	certain	certain	ADJ
fnp-3806	1158	24	amino	amino	ADJ
fnp-3806	1158	25	acids	acid	NOUN
fnp-3806	1158	26	.	.	PUNCT
fnp-3806	1159	1	lipoxidized	lipoxidize	VERB
fnp-3806	1159	2	proteins	protein	NOUN
fnp-3806	1159	3	are	be	AUX
fnp-3806	1159	4	mainly	mainly	ADV
fnp-3806	1159	5	those	those	PRON
fnp-3806	1159	6	involved	involve	VERB
fnp-3806	1159	7	in	in	ADP
fnp-3806	1159	8	energy	energy	NOUN
fnp-3806	1159	9	metabolism	metabolism	NOUN
fnp-3806	1159	10	,	,	PUNCT
fnp-3806	1159	11	cytoskeleton	cytoskeleton	PROPN
fnp-3806	1159	12	,	,	PUNCT
fnp-3806	1159	13	proteostasis	proteostasis	NOUN
fnp-3806	1159	14	,	,	PUNCT
fnp-3806	1159	15	neurotransmission	neurotransmission	NOUN
fnp-3806	1159	16	,	,	PUNCT
fnp-3806	1159	17	and	and	CCONJ
fnp-3806	1159	18	o2	o2	ADJ
fnp-3806	1159	19	/	/	SYM
fnp-3806	1159	20	co2	co2	NOUN
fnp-3806	1159	21	/	/	SYM
fnp-3806	1159	22	heme	heme	NOUN
fnp-3806	1159	23	metabolism	metabolism	NOUN
fnp-3806	1159	24	(	(	PUNCT
fnp-3806	1159	25	1452	1452	NUM
fnp-3806	1159	26	)	)	PUNCT
fnp-3806	1159	27	.	.	PUNCT
fnp-3806	1160	1	ages	age	NOUN
fnp-3806	1160	2	are	be	AUX
fnp-3806	1160	3	produced	produce	VERB
fnp-3806	1160	4	in	in	ADP
fnp-3806	1160	5	aging	aging	NOUN
fnp-3806	1160	6	and	and	CCONJ
fnp-3806	1160	7	sad	sad	ADJ
fnp-3806	1160	8	,	,	PUNCT
fnp-3806	1160	9	but	but	CCONJ
fnp-3806	1160	10	their	their	PRON
fnp-3806	1160	11	levels	level	NOUN
fnp-3806	1160	12	and	and	CCONJ
fnp-3806	1160	13	the	the	DET
fnp-3806	1160	14	levels	level	NOUN
fnp-3806	1160	15	of	of	ADP
fnp-3806	1160	16	their	their	PRON
fnp-3806	1160	17	receptor	receptor	NOUN
fnp-3806	1160	18	(	(	PUNCT
fnp-3806	1160	19	rage	rage	NOUN
fnp-3806	1160	20	)	)	PUNCT
fnp-3806	1160	21	do	do	AUX
fnp-3806	1160	22	not	not	PART
fnp-3806	1160	23	correlate	correlate	VERB
fnp-3806	1160	24	with	with	ADP
fnp-3806	1160	25	aβ	aβ	NOUN
fnp-3806	1160	26	levels	level	NOUN
fnp-3806	1160	27	,	,	PUNCT
fnp-3806	1160	28	tau	tau	PROPN
fnp-3806	1160	29	levels	level	NOUN
fnp-3806	1160	30	,	,	PUNCT
fnp-3806	1160	31	or	or	CCONJ
fnp-3806	1160	32	dementia	dementia	NOUN
fnp-3806	1160	33	(	(	PUNCT
fnp-3806	1160	34	1456	1456	NUM
fnp-3806	1160	35	,	,	PUNCT
fnp-3806	1160	36	1457	1457	NUM
fnp-3806	1160	37	)	)	PUNCT
fnp-3806	1160	38	.	.	PUNCT
fnp-3806	1161	1	most	most	ADJ
fnp-3806	1161	2	studies	study	NOUN
fnp-3806	1161	3	of	of	ADP
fnp-3806	1161	4	oxidative	oxidative	ADJ
fnp-3806	1161	5	stress	stress	NOUN
fnp-3806	1161	6	damage	damage	NOUN
fnp-3806	1161	7	in	in	ADP
fnp-3806	1161	8	sad	sad	ADJ
fnp-3806	1161	9	are	be	AUX
fnp-3806	1161	10	centered	center	VERB
fnp-3806	1161	11	on	on	ADP
fnp-3806	1161	12	stages	stage	NOUN
fnp-3806	1161	13	v	v	ADP
fnp-3806	1161	14	-	-	PUNCT
fnp-3806	1161	15	vi	vi	NOUN
fnp-3806	1161	16	(	(	PUNCT
fnp-3806	1161	17	cases	case	NOUN
fnp-3806	1161	18	with	with	ADP
fnp-3806	1161	19	dementia	dementia	NOUN
fnp-3806	1161	20	)	)	PUNCT
fnp-3806	1161	21	and	and	CCONJ
fnp-3806	1161	22	iii	iii	X
fnp-3806	1161	23	-	-	PUNCT
fnp-3806	1161	24	iv	iv	NUM
fnp-3806	1161	25	(	(	PUNCT
fnp-3806	1161	26	cases	case	NOUN
fnp-3806	1161	27	with	with	ADP
fnp-3806	1161	28	mci	mci	NOUN
fnp-3806	1161	29	)	)	PUNCT
fnp-3806	1161	30	.	.	PUNCT
fnp-3806	1162	1	proteins	protein	NOUN
fnp-3806	1162	2	involved	involve	VERB
fnp-3806	1162	3	in	in	ADP
fnp-3806	1162	4	glycolysis	glycolysis	NOUN
fnp-3806	1162	5	and	and	CCONJ
fnp-3806	1162	6	energy	energy	NOUN
fnp-3806	1162	7	metabolism	metabolism	NOUN
fnp-3806	1162	8	,	,	PUNCT
fnp-3806	1162	9	in	in	ADP
fnp-3806	1162	10	electron	electron	NOUN
fnp-3806	1162	11	transport	transport	NOUN
fnp-3806	1162	12	chain	chain	NOUN
fnp-3806	1162	13	,	,	PUNCT
fnp-3806	1162	14	oxidative	oxidative	ADJ
fnp-3806	1162	15	phosphorylation	phosphorylation	NOUN
fnp-3806	1162	16	,	,	PUNCT
fnp-3806	1162	17	and	and	CCONJ
fnp-3806	1162	18	other	other	ADJ
fnp-3806	1162	19	mitochondrial	mitochondrial	ADJ
fnp-3806	1162	20	components	component	NOUN
fnp-3806	1162	21	;	;	PUNCT
fnp-3806	1162	22	structural	structural	ADJ
fnp-3806	1162	23	proteins	protein	NOUN
fnp-3806	1162	24	;	;	PUNCT
fnp-3806	1162	25	chaperones	chaperone	NOUN
fnp-3806	1162	26	;	;	PUNCT
fnp-3806	1162	27	stress	stress	NOUN
fnp-3806	1162	28	proteins	protein	NOUN
fnp-3806	1162	29	,	,	PUNCT
fnp-3806	1162	30	and	and	CCONJ
fnp-3806	1162	31	stress	stress	NOUN
fnp-3806	1162	32	responses	response	NOUN
fnp-3806	1162	33	;	;	PUNCT
fnp-3806	1162	34	and	and	CCONJ
fnp-3806	1162	35	proteins	protein	NOUN
fnp-3806	1162	36	of	of	ADP
fnp-3806	1162	37	the	the	DET
fnp-3806	1162	38	ups	up	NOUN
fnp-3806	1162	39	are	be	AUX
fnp-3806	1162	40	all	all	PRON
fnp-3806	1162	41	targets	target	NOUN
fnp-3806	1162	42	of	of	ADP
fnp-3806	1162	43	oxidative	oxidative	ADJ
fnp-3806	1162	44	damage	damage	NOUN
fnp-3806	1162	45	(	(	PUNCT
fnp-3806	1162	46	1373	1373	NUM
fnp-3806	1162	47	,	,	PUNCT
fnp-3806	1162	48	1458	1458	NUM
fnp-3806	1162	49	-	-	SYM
fnp-3806	1162	50	1467	1467	NUM
fnp-3806	1162	51	)	)	PUNCT
fnp-3806	1162	52	.	.	PUNCT
fnp-3806	1163	1	protein	protein	NOUN
fnp-3806	1163	2	oxidative	oxidative	ADJ
fnp-3806	1163	3	damage	damage	NOUN
fnp-3806	1163	4	is	be	AUX
fnp-3806	1163	5	usually	usually	ADV
fnp-3806	1163	6	accompanied	accompany	VERB
fnp-3806	1163	7	by	by	ADP
fnp-3806	1163	8	decreased	decrease	VERB
fnp-3806	1163	9	functional	functional	ADJ
fnp-3806	1163	10	activity	activity	NOUN
fnp-3806	1163	11	(	(	PUNCT
fnp-3806	1163	12	1468	1468	NUM
fnp-3806	1163	13	)	)	PUNCT
fnp-3806	1163	14	.	.	PUNCT
fnp-3806	1164	1	altered	alter	VERB
fnp-3806	1164	2	enzymatic	enzymatic	ADJ
fnp-3806	1164	3	activity	activity	NOUN
fnp-3806	1164	4	has	have	AUX
fnp-3806	1164	5	been	be	AUX
fnp-3806	1164	6	demonstrated	demonstrate	VERB
fnp-3806	1164	7	for	for	ADP
fnp-3806	1164	8	the	the	DET
fnp-3806	1164	9	oxidized	oxidize	VERB
fnp-3806	1164	10	protein	protein	NOUN
fnp-3806	1164	11	creatine	creatine	NOUN
fnp-3806	1164	12	kinase	kinase	PROPN
fnp-3806	1164	13	bb	bb	PROPN
fnp-3806	1164	14	,	,	PUNCT
fnp-3806	1164	15	enolase	enolase	VERB
fnp-3806	1164	16	1	1	NUM
fnp-3806	1164	17	,	,	PUNCT
fnp-3806	1164	18	glutamine	glutamine	NOUN
fnp-3806	1164	19	synthetase	synthetase	NOUN
fnp-3806	1164	20	,	,	PUNCT
fnp-3806	1164	21	pin-1	pin-1	ADV
fnp-3806	1164	22	,	,	PUNCT
fnp-3806	1164	23	carbonic	carbonic	ADJ
fnp-3806	1164	24	anhydrase	anhydrase	NOUN
fnp-3806	1164	25	2	2	NUM
fnp-3806	1164	26	,	,	PUNCT
fnp-3806	1164	27	uchl-1	uchl-1	NUM
fnp-3806	1164	28	,	,	PUNCT
fnp-3806	1164	29	α	α	NOUN
fnp-3806	1164	30	-	-	PUNCT
fnp-3806	1164	31	enolase	enolase	NOUN
fnp-3806	1164	32	,	,	PUNCT
fnp-3806	1164	33	gapdh	gapdh	NOUN
fnp-3806	1164	34	,	,	PUNCT
fnp-3806	1164	35	gdh	gdh	PROPN
fnp-3806	1164	36	,	,	PUNCT
fnp-3806	1164	37	h+	h+	PUNCT
fnp-3806	1164	38	transporting	transport	VERB
fnp-3806	1164	39	atpase	atpase	PROPN
fnp-3806	1164	40	,	,	PUNCT
fnp-3806	1164	41	ldh	ldh	PROPN
fnp-3806	1164	42	,	,	PUNCT
fnp-3806	1164	43	atp	atp	NOUN
fnp-3806	1164	44	synthase	synthase	NOUN
fnp-3806	1164	45	,	,	PUNCT
fnp-3806	1164	46	and	and	CCONJ
fnp-3806	1164	47	pyruvate	pyruvate	NOUN
fnp-3806	1164	48	kinase	kinase	NOUN
fnp-3806	1164	49	in	in	ADP
fnp-3806	1164	50	sad	sad	ADJ
fnp-3806	1164	51	.	.	PUNCT
fnp-3806	1165	1	a	a	DET
fnp-3806	1165	2	few	few	ADJ
fnp-3806	1165	3	studies	study	NOUN
fnp-3806	1165	4	have	have	AUX
fnp-3806	1165	5	included	include	VERB
fnp-3806	1165	6	the	the	DET
fnp-3806	1165	7	identification	identification	NOUN
fnp-3806	1165	8	of	of	ADP
fnp-3806	1165	9	oxidatively	oxidatively	ADV
fnp-3806	1165	10	damaged	damage	VERB
fnp-3806	1165	11	protein	protein	NOUN
fnp-3806	1165	12	,	,	PUNCT
fnp-3806	1165	13	the	the	DET
fnp-3806	1165	14	quantification	quantification	NOUN
fnp-3806	1165	15	of	of	ADP
fnp-3806	1165	16	total	total	ADJ
fnp-3806	1165	17	protein	protein	NOUN
fnp-3806	1165	18	levels	level	NOUN
fnp-3806	1165	19	,	,	PUNCT
fnp-3806	1165	20	and	and	CCONJ
fnp-3806	1165	21	the	the	DET
fnp-3806	1165	22	reduction	reduction	NOUN
fnp-3806	1165	23	of	of	ADP
fnp-3806	1165	24	enzymatic	enzymatic	ADJ
fnp-3806	1165	25	activity	activity	NOUN
fnp-3806	1165	26	(	(	PUNCT
fnp-3806	1165	27	1381	1381	NUM
fnp-3806	1165	28	)	)	PUNCT
fnp-3806	1165	29	.	.	PUNCT
fnp-3806	1166	1	in	in	ADP
fnp-3806	1166	2	an	an	DET
fnp-3806	1166	3	attempt	attempt	NOUN
fnp-3806	1166	4	to	to	PART
fnp-3806	1166	5	correlate	correlate	VERB
fnp-3806	1166	6	oxidative	oxidative	ADJ
fnp-3806	1166	7	stress	stress	NOUN
fnp-3806	1166	8	damage	damage	NOUN
fnp-3806	1166	9	and	and	CCONJ
fnp-3806	1166	10	regional	regional	ADJ
fnp-3806	1166	11	vulnerability	vulnerability	NOUN
fnp-3806	1166	12	in	in	ADP
fnp-3806	1166	13	sad	sad	ADJ
fnp-3806	1166	14	,	,	PUNCT
fnp-3806	1166	15	a	a	DET
fnp-3806	1166	16	meta	meta	NOUN
fnp-3806	1166	17	-	-	PUNCT
fnp-3806	1166	18	analysis	analysis	NOUN
fnp-3806	1166	19	of	of	ADP
fnp-3806	1166	20	mda	mda	PROPN
fnp-3806	1166	21	,	,	PUNCT
fnp-3806	1166	22	hne	hne	PROPN
fnp-3806	1166	23	,	,	PUNCT
fnp-3806	1166	24	protein	protein	NOUN
fnp-3806	1166	25	carbonylation	carbonylation	NOUN
fnp-3806	1166	26	,	,	PUNCT
fnp-3806	1166	27	8	8	NUM
fnp-3806	1166	28	-	-	PUNCT
fnp-3806	1166	29	hydroxyguanine	hydroxyguanine	NOUN
fnp-3806	1166	30	levels	level	NOUN
fnp-3806	1166	31	and	and	CCONJ
fnp-3806	1166	32	superoxide	superoxide	NOUN
fnp-3806	1166	33	dismutase	dismutase	NOUN
fnp-3806	1166	34	,	,	PUNCT
fnp-3806	1166	35	glutathione	glutathione	NOUN
fnp-3806	1166	36	peroxidase	peroxidase	NOUN
fnp-3806	1166	37	,	,	PUNCT
fnp-3806	1166	38	glutathione	glutathione	NOUN
fnp-3806	1166	39	reductase	reductase	NOUN
fnp-3806	1166	40	,	,	PUNCT
fnp-3806	1166	41	and	and	CCONJ
fnp-3806	1166	42	catalase	catalase	NOUN
fnp-3806	1166	43	activities	activity	NOUN
fnp-3806	1166	44	showed	show	VERB
fnp-3806	1166	45	that	that	SCONJ
fnp-3806	1166	46	changes	change	NOUN
fnp-3806	1166	47	linked	link	VERB
fnp-3806	1166	48	to	to	ADP
fnp-3806	1166	49	oxidative	oxidative	ADJ
fnp-3806	1166	50	stress	stress	NOUN
fnp-3806	1166	51	were	be	AUX
fnp-3806	1166	52	variable	variable	ADJ
fnp-3806	1166	53	from	from	ADP
fnp-3806	1166	54	one	one	NUM
fnp-3806	1166	55	region	region	NOUN
fnp-3806	1166	56	to	to	ADP
fnp-3806	1166	57	another	another	PRON
fnp-3806	1166	58	and	and	CCONJ
fnp-3806	1166	59	dependent	dependent	ADJ
fnp-3806	1166	60	on	on	ADP
fnp-3806	1166	61	the	the	DET
fnp-3806	1166	62	type	type	NOUN
fnp-3806	1166	63	of	of	ADP
fnp-3806	1166	64	adduct	adduct	NOUN
fnp-3806	1166	65	.	.	PUNCT
fnp-3806	1167	1	no	no	DET
fnp-3806	1167	2	correlation	correlation	NOUN
fnp-3806	1167	3	was	be	AUX
fnp-3806	1167	4	seen	see	VERB
fnp-3806	1167	5	between	between	ADP
fnp-3806	1167	6	oxidative	oxidative	ADJ
fnp-3806	1167	7	damage	damage	NOUN
fnp-3806	1167	8	and	and	CCONJ
fnp-3806	1167	9	regional	regional	ADJ
fnp-3806	1167	10	vulnerability	vulnerability	NOUN
fnp-3806	1167	11	(	(	PUNCT
fnp-3806	1167	12	1469	1469	NUM
fnp-3806	1167	13	)	)	PUNCT
fnp-3806	1167	14	.	.	PUNCT
fnp-3806	1168	1	oxidative	oxidative	ADJ
fnp-3806	1168	2	damage	damage	NOUN
fnp-3806	1168	3	was	be	AUX
fnp-3806	1168	4	advocated	advocate	VERB
fnp-3806	1168	5	to	to	PART
fnp-3806	1168	6	be	be	AUX
fnp-3806	1168	7	the	the	DET
fnp-3806	1168	8	earliest	early	ADJ
fnp-3806	1168	9	event	event	NOUN
fnp-3806	1168	10	in	in	ADP
fnp-3806	1168	11	sad	sad	ADJ
fnp-3806	1168	12	(	(	PUNCT
fnp-3806	1168	13	1470	1470	NUM
fnp-3806	1168	14	)	)	PUNCT
fnp-3806	1168	15	.	.	PUNCT
fnp-3806	1169	1	further	further	ADJ
fnp-3806	1169	2	research	research	NOUN
fnp-3806	1169	3	revealed	reveal	VERB
fnp-3806	1169	4	that	that	SCONJ
fnp-3806	1169	5	oxidative	oxidative	ADJ
fnp-3806	1169	6	damage	damage	NOUN
fnp-3806	1169	7	was	be	AUX
fnp-3806	1169	8	more	more	ADV
fnp-3806	1169	9	marked	mark	VERB
fnp-3806	1169	10	in	in	ADP
fnp-3806	1169	11	younger	young	ADJ
fnp-3806	1169	12	cases	case	NOUN
fnp-3806	1169	13	,	,	PUNCT
fnp-3806	1169	14	in	in	ADP
fnp-3806	1169	15	cases	case	NOUN
fnp-3806	1169	16	with	with	ADP
fnp-3806	1169	17	rapid	rapid	ADJ
fnp-3806	1169	18	disease	disease	NOUN
fnp-3806	1169	19	progression	progression	NOUN
fnp-3806	1169	20	,	,	PUNCT
fnp-3806	1169	21	and	and	CCONJ
fnp-3806	1169	22	in	in	ADP
fnp-3806	1169	23	neurons	neuron	NOUN
fnp-3806	1169	24	without	without	ADP
fnp-3806	1169	25	nfts	nft	NOUN
fnp-3806	1169	26	when	when	SCONJ
fnp-3806	1169	27	compared	compare	VERB
fnp-3806	1169	28	with	with	ADP
fnp-3806	1169	29	neurons	neuron	NOUN
fnp-3806	1169	30	with	with	ADP
fnp-3806	1169	31	tangles	tangle	NOUN
fnp-3806	1169	32	in	in	ADP
fnp-3806	1169	33	the	the	DET
fnp-3806	1169	34	same	same	ADJ
fnp-3806	1169	35	individual	individual	NOUN
fnp-3806	1169	36	(	(	PUNCT
fnp-3806	1169	37	1471	1471	NUM
fnp-3806	1169	38	)	)	PUNCT
fnp-3806	1169	39	.	.	PUNCT
fnp-3806	1170	1	moreover	moreover	ADV
fnp-3806	1170	2	,	,	PUNCT
fnp-3806	1170	3	oxidative	oxidative	ADJ
fnp-3806	1170	4	stress	stress	NOUN
fnp-3806	1170	5	precedes	precede	VERB
fnp-3806	1170	6	β	β	NOUN
fnp-3806	1170	7	-	-	NOUN
fnp-3806	1170	8	amyloid	amyloid	ADJ
fnp-3806	1170	9	deposition	deposition	NOUN
fnp-3806	1170	10	in	in	ADP
fnp-3806	1170	11	pre	pre	ADJ
fnp-3806	1170	12	-	-	ADJ
fnp-3806	1170	13	symptomatic	symptomatic	ADJ
fnp-3806	1170	14	fad	fad	NOUN
fnp-3806	1170	15	and	and	CCONJ
fnp-3806	1170	16	down	down	ADP
fnp-3806	1170	17	syndrome	syndrome	NOUN
fnp-3806	1170	18	(	(	PUNCT
fnp-3806	1170	19	1472	1472	NUM
fnp-3806	1170	20	,	,	PUNCT
fnp-3806	1170	21	1473	1473	NUM
fnp-3806	1170	22	)	)	PUNCT
fnp-3806	1170	23	.	.	PUNCT
fnp-3806	1171	1	early	early	ADJ
fnp-3806	1171	2	observations	observation	NOUN
fnp-3806	1171	3	suggested	suggest	VERB
fnp-3806	1171	4	that	that	SCONJ
fnp-3806	1171	5	oxidative	oxidative	ADJ
fnp-3806	1171	6	post	post	ADJ
fnp-3806	1171	7	-	-	ADJ
fnp-3806	1171	8	translational	translational	ADJ
fnp-3806	1171	9	modifications	modification	NOUN
fnp-3806	1171	10	might	might	AUX
fnp-3806	1171	11	play	play	VERB
fnp-3806	1171	12	a	a	DET
fnp-3806	1171	13	role	role	NOUN
fnp-3806	1171	14	in	in	ADP
fnp-3806	1171	15	the	the	DET
fnp-3806	1171	16	formation	formation	NOUN
fnp-3806	1171	17	of	of	ADP
fnp-3806	1171	18	sps	sps	NOUN
fnp-3806	1171	19	and	and	CCONJ
fnp-3806	1171	20	nfts	nft	NOUN
fnp-3806	1171	21	(	(	PUNCT
fnp-3806	1171	22	1474	1474	NUM
fnp-3806	1171	23	)	)	PUNCT
fnp-3806	1171	24	.	.	PUNCT
fnp-3806	1172	1	following	follow	VERB
fnp-3806	1172	2	this	this	DET
fnp-3806	1172	3	argument	argument	NOUN
fnp-3806	1172	4	,	,	PUNCT
fnp-3806	1172	5	aggregation	aggregation	NOUN
fnp-3806	1172	6	of	of	ADP
fnp-3806	1172	7	aβ	aβ	NOUN
fnp-3806	1172	8	and	and	CCONJ
fnp-3806	1172	9	tau	tau	PROPN
fnp-3806	1172	10	was	be	AUX
fnp-3806	1172	11	considered	consider	VERB
fnp-3806	1172	12	a	a	DET
fnp-3806	1172	13	compensatory	compensatory	ADJ
fnp-3806	1172	14	response	response	NOUN
fnp-3806	1172	15	to	to	ADP
fnp-3806	1172	16	underlying	underlie	VERB
fnp-3806	1172	17	oxidative	oxidative	ADJ
fnp-3806	1172	18	stress	stress	NOUN
fnp-3806	1172	19	(	(	PUNCT
fnp-3806	1172	20	1475	1475	NUM
fnp-3806	1172	21	)	)	PUNCT
fnp-3806	1172	22	.	.	PUNCT
fnp-3806	1173	1	however	however	ADV
fnp-3806	1173	2	,	,	PUNCT
fnp-3806	1173	3	β	β	X
fnp-3806	1173	4	-	-	NOUN
fnp-3806	1173	5	amyloid	amyloid	NOUN
fnp-3806	1173	6	is	be	AUX
fnp-3806	1173	7	also	also	ADV
fnp-3806	1173	8	a	a	DET
fnp-3806	1173	9	cause	cause	NOUN
fnp-3806	1173	10	of	of	ADP
fnp-3806	1173	11	oxidative	oxidative	ADJ
fnp-3806	1173	12	stress	stress	NOUN
fnp-3806	1173	13	,	,	PUNCT
fnp-3806	1173	14	thereby	thereby	ADV
fnp-3806	1173	15	potentiating	potentiate	VERB
fnp-3806	1173	16	the	the	DET
fnp-3806	1173	17	loop	loop	NOUN
fnp-3806	1173	18	(	(	PUNCT
fnp-3806	1173	19	1476	1476	NUM
fnp-3806	1173	20	)	)	PUNCT
fnp-3806	1173	21	.	.	PUNCT
fnp-3806	1174	1	oxidative	oxidative	ADJ
fnp-3806	1174	2	stress	stress	NOUN
fnp-3806	1174	3	generates	generate	VERB
fnp-3806	1174	4	mitochondrial	mitochondrial	ADJ
fnp-3806	1174	5	dysfunction	dysfunction	NOUN
fnp-3806	1174	6	by	by	ADP
fnp-3806	1174	7	damaging	damage	VERB
fnp-3806	1174	8	structural	structural	ADJ
fnp-3806	1174	9	proteins	protein	NOUN
fnp-3806	1174	10	and	and	CCONJ
fnp-3806	1174	11	components	component	NOUN
fnp-3806	1174	12	of	of	ADP
fnp-3806	1174	13	the	the	DET
fnp-3806	1174	14	mitochondrial	mitochondrial	ADJ
fnp-3806	1174	15	respiratory	respiratory	ADJ
fnp-3806	1174	16	chain	chain	NOUN
fnp-3806	1174	17	in	in	ADP
fnp-3806	1174	18	sad	sad	ADJ
fnp-3806	1174	19	(	(	PUNCT
fnp-3806	1174	20	1438	1438	NUM
fnp-3806	1174	21	,	,	PUNCT
fnp-3806	1174	22	1477	1477	NUM
fnp-3806	1174	23	-	-	SYM
fnp-3806	1174	24	1479	1479	NUM
fnp-3806	1174	25	)	)	PUNCT
fnp-3806	1174	26	.	.	PUNCT
fnp-3806	1175	1	oxidative	oxidative	ADJ
fnp-3806	1175	2	damage	damage	NOUN
fnp-3806	1175	3	also	also	ADV
fnp-3806	1175	4	causes	cause	VERB
fnp-3806	1175	5	synaptic	synaptic	ADJ
fnp-3806	1175	6	dysfunction	dysfunction	NOUN
fnp-3806	1175	7	(	(	PUNCT
fnp-3806	1175	8	425	425	NUM
fnp-3806	1175	9	)	)	PUNCT
fnp-3806	1175	10	.	.	PUNCT
fnp-3806	1176	1	as	as	SCONJ
fnp-3806	1176	2	indicated	indicate	VERB
fnp-3806	1176	3	in	in	ADP
fnp-3806	1176	4	previous	previous	ADJ
fnp-3806	1176	5	paragraphs	paragraph	NOUN
fnp-3806	1176	6	,	,	PUNCT
fnp-3806	1176	7	oxidative	oxidative	ADJ
fnp-3806	1176	8	damage	damage	NOUN
fnp-3806	1176	9	of	of	ADP
fnp-3806	1176	10	atp	atp	NOUN
fnp-3806	1176	11	-	-	PUNCT
fnp-3806	1176	12	synthase	synthase	NOUN
fnp-3806	1176	13	resulting	result	VERB
fnp-3806	1176	14	in	in	ADP
fnp-3806	1176	15	the	the	DET
fnp-3806	1176	16	loss	loss	NOUN
fnp-3806	1176	17	of	of	ADP
fnp-3806	1176	18	its	its	PRON
fnp-3806	1176	19	function	function	NOUN
fnp-3806	1176	20	occurs	occur	VERB
fnp-3806	1176	21	at	at	ADP
fnp-3806	1176	22	stages	stage	NOUN
fnp-3806	1176	23	i	i	PROPN
fnp-3806	1176	24	-	-	PUNCT
fnp-3806	1176	25	ii	ii	PROPN
fnp-3806	1176	26	of	of	ADP
fnp-3806	1176	27	nft	nft	PROPN
fnp-3806	1176	28	pathology	pathology	PROPN
fnp-3806	1176	29	(	(	PUNCT
fnp-3806	1176	30	1438	1438	NUM
fnp-3806	1176	31	)	)	PUNCT
fnp-3806	1176	32	.	.	PUNCT
fnp-3806	1177	1	mitochondrial	mitochondrial	ADJ
fnp-3806	1177	2	dysfunction	dysfunction	NOUN
fnp-3806	1177	3	,	,	PUNCT
fnp-3806	1177	4	abnormalities	abnormality	NOUN
fnp-3806	1177	5	in	in	ADP
fnp-3806	1177	6	lipid	lipid	ADJ
fnp-3806	1177	7	rafts	raft	NOUN
fnp-3806	1177	8	,	,	PUNCT
fnp-3806	1177	9	and	and	CCONJ
fnp-3806	1177	10	oxidative	oxidative	ADJ
fnp-3806	1177	11	stress	stress	NOUN
fnp-3806	1177	12	damage	damage	NOUN
fnp-3806	1177	13	potentiate	potentiate	VERB
fnp-3806	1177	14	each	each	DET
fnp-3806	1177	15	other	other	ADJ
fnp-3806	1177	16	and	and	CCONJ
fnp-3806	1177	17	are	be	AUX
fnp-3806	1177	18	major	major	ADJ
fnp-3806	1177	19	players	player	NOUN
fnp-3806	1177	20	in	in	ADP
fnp-3806	1177	21	neuronal	neuronal	ADJ
fnp-3806	1177	22	energy	energy	NOUN
fnp-3806	1177	23	failure	failure	NOUN
fnp-3806	1177	24	at	at	ADP
fnp-3806	1177	25	the	the	DET
fnp-3806	1177	26	first	first	ADJ
fnp-3806	1177	27	stages	stage	NOUN
fnp-3806	1177	28	of	of	ADP
fnp-3806	1177	29	nft	nft	PROPN
fnp-3806	1177	30	pathology	pathology	PROPN
fnp-3806	1177	31	(	(	PUNCT
fnp-3806	1177	32	1480	1480	NUM
fnp-3806	1177	33	)	)	PUNCT
fnp-3806	1177	34	.	.	PUNCT
fnp-3806	1178	1	another	another	DET
fnp-3806	1178	2	relevant	relevant	ADJ
fnp-3806	1178	3	consequence	consequence	NOUN
fnp-3806	1178	4	of	of	ADP
fnp-3806	1178	5	oxidative	oxidative	ADJ
fnp-3806	1178	6	stress	stress	NOUN
fnp-3806	1178	7	is	be	AUX
fnp-3806	1178	8	the	the	DET
fnp-3806	1178	9	effect	effect	NOUN
fnp-3806	1178	10	of	of	ADP
fnp-3806	1178	11	advanced	advanced	ADJ
fnp-3806	1178	12	glycation	glycation	NOUN
fnp-3806	1178	13	end	end	NOUN
fnp-3806	1178	14	products	product	NOUN
fnp-3806	1178	15	on	on	ADP
fnp-3806	1178	16	cell	cell	NOUN
fnp-3806	1178	17	-	-	PUNCT
fnp-3806	1178	18	cycle	cycle	NOUN
fnp-3806	1178	19	re	re	NOUN
fnp-3806	1178	20	-	-	NOUN
fnp-3806	1178	21	entry	entry	NOUN
fnp-3806	1178	22	and	and	CCONJ
fnp-3806	1178	23	arrest	arrest	NOUN
fnp-3806	1178	24	,	,	PUNCT
fnp-3806	1178	25	also	also	ADV
fnp-3806	1178	26	occurring	occur	VERB
fnp-3806	1178	27	at	at	ADP
fnp-3806	1178	28	the	the	DET
fnp-3806	1178	29	first	first	ADJ
fnp-3806	1178	30	stages	stage	NOUN
fnp-3806	1178	31	of	of	ADP
fnp-3806	1178	32	sad	sad	ADJ
fnp-3806	1178	33	(	(	PUNCT
fnp-3806	1178	34	1481	1481	NUM
fnp-3806	1178	35	)	)	PUNCT
fnp-3806	1178	36	.	.	PUNCT
fnp-3806	1179	1	22f	22f	NUM
fnp-3806	1179	2	.	.	PUNCT
fnp-3806	1180	1	inflammation	inflammation	NOUN
fnp-3806	1180	2	aging	aging	NOUN
fnp-3806	1180	3	is	be	AUX
fnp-3806	1180	4	accompanied	accompany	VERB
fnp-3806	1180	5	by	by	ADP
fnp-3806	1180	6	low	low	ADJ
fnp-3806	1180	7	levels	level	NOUN
fnp-3806	1180	8	of	of	ADP
fnp-3806	1180	9	activated	activated	ADJ
fnp-3806	1180	10	innate	innate	ADJ
fnp-3806	1180	11	inflammatory	inflammatory	ADJ
fnp-3806	1180	12	responses	response	NOUN
fnp-3806	1180	13	(	(	PUNCT
fnp-3806	1180	14	1482	1482	NUM
fnp-3806	1180	15	,	,	PUNCT
fnp-3806	1180	16	1483	1483	NUM
fnp-3806	1180	17	)	)	PUNCT
fnp-3806	1180	18	.	.	PUNCT
fnp-3806	1181	1	the	the	DET
fnp-3806	1181	2	role	role	NOUN
fnp-3806	1181	3	of	of	ADP
fnp-3806	1181	4	microglia	microglia	NOUN
fnp-3806	1181	5	and	and	CCONJ
fnp-3806	1181	6	inflammation	inflammation	NOUN
fnp-3806	1181	7	in	in	ADP
fnp-3806	1181	8	the	the	DET
fnp-3806	1181	9	aging	age	VERB
fnp-3806	1181	10	brain	brain	NOUN
fnp-3806	1181	11	and	and	CCONJ
fnp-3806	1181	12	sad	sad	ADJ
fnp-3806	1181	13	has	have	AUX
fnp-3806	1181	14	been	be	AUX
fnp-3806	1181	15	discussed	discuss	VERB
fnp-3806	1181	16	in	in	ADP
fnp-3806	1181	17	previous	previous	ADJ
fnp-3806	1181	18	paragraphs	paragraph	NOUN
fnp-3806	1181	19	.	.	PUNCT
fnp-3806	1182	1	here	here	ADV
fnp-3806	1182	2	,	,	PUNCT
fnp-3806	1182	3	the	the	DET
fnp-3806	1182	4	focus	focus	NOUN
fnp-3806	1182	5	is	be	AUX
fnp-3806	1182	6	on	on	ADP
fnp-3806	1182	7	the	the	DET
fnp-3806	1182	8	relevance	relevance	NOUN
fnp-3806	1182	9	of	of	ADP
fnp-3806	1182	10	inflammatory	inflammatory	ADJ
fnp-3806	1182	11	changes	change	NOUN
fnp-3806	1182	12	in	in	ADP
fnp-3806	1182	13	brain	brain	NOUN
fnp-3806	1182	14	aging	aging	NOUN
fnp-3806	1182	15	and	and	CCONJ
fnp-3806	1182	16	at	at	ADP
fnp-3806	1182	17	early	early	ADJ
fnp-3806	1182	18	stages	stage	NOUN
fnp-3806	1182	19	of	of	ADP
fnp-3806	1182	20	ad	ad	NOUN
fnp-3806	1182	21	pathology	pathology	NOUN
fnp-3806	1182	22	.	.	PUNCT
fnp-3806	1183	1	several	several	ADJ
fnp-3806	1183	2	reports	report	NOUN
fnp-3806	1183	3	in	in	ADP
fnp-3806	1183	4	the	the	DET
fnp-3806	1183	5	1990s	1990	NOUN
fnp-3806	1183	6	described	describe	VERB
fnp-3806	1183	7	a	a	DET
fnp-3806	1183	8	protective	protective	ADJ
fnp-3806	1183	9	effect	effect	NOUN
fnp-3806	1183	10	of	of	ADP
fnp-3806	1183	11	non	non	ADJ
fnp-3806	1183	12	-	-	ADJ
fnp-3806	1183	13	steroidal	steroidal	ADJ
fnp-3806	1183	14	anti	anti	ADJ
fnp-3806	1183	15	-	-	ADJ
fnp-3806	1183	16	inflammatory	inflammatory	ADJ
fnp-3806	1183	17	drugs	drug	NOUN
fnp-3806	1183	18	used	use	VERB
fnp-3806	1183	19	for	for	ADP
fnp-3806	1183	20	the	the	DET
fnp-3806	1183	21	treatment	treatment	NOUN
fnp-3806	1183	22	of	of	ADP
fnp-3806	1183	23	autoimmnune	autoimmnune	ADJ
fnp-3806	1183	24	diseases	disease	NOUN
fnp-3806	1183	25	on	on	ADP
fnp-3806	1183	26	the	the	DET
fnp-3806	1183	27	manifestation	manifestation	NOUN
fnp-3806	1183	28	and	and	CCONJ
fnp-3806	1183	29	progression	progression	NOUN
fnp-3806	1183	30	of	of	ADP
fnp-3806	1183	31	sad	sad	ADJ
fnp-3806	1183	32	(	(	PUNCT
fnp-3806	1183	33	1484	1484	NUM
fnp-3806	1183	34	-	-	SYM
fnp-3806	1183	35	1490	1490	NUM
fnp-3806	1183	36	)	)	PUNCT
fnp-3806	1183	37	.	.	PUNCT
fnp-3806	1184	1	further	further	ADJ
fnp-3806	1184	2	studies	study	NOUN
fnp-3806	1184	3	delineated	delineate	VERB
fnp-3806	1184	4	their	their	PRON
fnp-3806	1184	5	positive	positive	ADJ
fnp-3806	1184	6	effects	effect	NOUN
fnp-3806	1184	7	when	when	SCONJ
fnp-3806	1184	8	the	the	DET
fnp-3806	1184	9	treatment	treatment	NOUN
fnp-3806	1184	10	was	be	AUX
fnp-3806	1184	11	initiated	initiate	VERB
fnp-3806	1184	12	before	before	ADP
fnp-3806	1184	13	the	the	DET
fnp-3806	1184	14	appearance	appearance	NOUN
fnp-3806	1184	15	of	of	ADP
fnp-3806	1184	16	cognitive	cognitive	ADJ
fnp-3806	1184	17	impairment	impairment	NOUN
fnp-3806	1184	18	,	,	PUNCT
fnp-3806	1184	19	but	but	CCONJ
fnp-3806	1184	20	the	the	DET
fnp-3806	1184	21	effects	effect	NOUN
fnp-3806	1184	22	of	of	ADP
fnp-3806	1184	23	the	the	DET
fnp-3806	1184	24	same	same	ADJ
fnp-3806	1184	25	treatments	treatment	NOUN
fnp-3806	1184	26	were	be	AUX
fnp-3806	1184	27	minimal	minimal	ADJ
fnp-3806	1184	28	when	when	SCONJ
fnp-3806	1184	29	administered	administer	VERB
fnp-3806	1184	30	in	in	ADP
fnp-3806	1184	31	advanced	advanced	ADJ
fnp-3806	1184	32	ad	ad	NOUN
fnp-3806	1184	33	.	.	PUNCT
fnp-3806	1185	1	these	these	DET
fnp-3806	1185	2	observations	observation	NOUN
fnp-3806	1185	3	show	show	VERB
fnp-3806	1185	4	that	that	SCONJ
fnp-3806	1185	5	inflammatory	inflammatory	ADJ
fnp-3806	1185	6	responses	response	NOUN
fnp-3806	1185	7	modulate	modulate	VERB
fnp-3806	1185	8	the	the	DET
fnp-3806	1185	9	history	history	NOUN
fnp-3806	1185	10	of	of	ADP
fnp-3806	1185	11	ad	ad	NOUN
fnp-3806	1185	12	at	at	ADP
fnp-3806	1185	13	the	the	DET
fnp-3806	1185	14	early	early	ADJ
fnp-3806	1185	15	stages	stage	NOUN
fnp-3806	1185	16	of	of	ADP
fnp-3806	1185	17	the	the	DET
fnp-3806	1185	18	process	process	NOUN
fnp-3806	1185	19	.	.	PUNCT
fnp-3806	1186	1	more	more	ADV
fnp-3806	1186	2	importantly	importantly	ADV
fnp-3806	1186	3	,	,	PUNCT
fnp-3806	1186	4	there	there	PRON
fnp-3806	1186	5	is	be	VERB
fnp-3806	1186	6	also	also	ADV
fnp-3806	1186	7	a	a	DET
fnp-3806	1186	8	chance	chance	NOUN
fnp-3806	1186	9	for	for	ADP
fnp-3806	1186	10	anti	anti	ADJ
fnp-3806	1186	11	-	-	ADJ
fnp-3806	1186	12	inflammatory	inflammatory	ADJ
fnp-3806	1186	13	drugs	drug	NOUN
fnp-3806	1186	14	in	in	ADP
fnp-3806	1186	15	the	the	DET
fnp-3806	1186	16	treatment	treatment	NOUN
fnp-3806	1186	17	of	of	ADP
fnp-3806	1186	18	sad	sad	ADJ
fnp-3806	1186	19	when	when	SCONJ
fnp-3806	1186	20	administered	administer	VERB
fnp-3806	1186	21	at	at	ADP
fnp-3806	1186	22	the	the	DET
fnp-3806	1186	23	appropriate	appropriate	ADJ
fnp-3806	1186	24	time	time	NOUN
fnp-3806	1186	25	(	(	PUNCT
fnp-3806	1186	26	1491	1491	NUM
fnp-3806	1186	27	-	-	SYM
fnp-3806	1186	28	1493	1493	NUM
fnp-3806	1186	29	)	)	PUNCT
fnp-3806	1186	30	.	.	PUNCT
fnp-3806	1187	1	molecular	molecular	ADJ
fnp-3806	1187	2	studies	study	NOUN
fnp-3806	1187	3	disclosed	disclose	VERB
fnp-3806	1187	4	that	that	SCONJ
fnp-3806	1187	5	multiple	multiple	ADJ
fnp-3806	1187	6	cytokines	cytokine	NOUN
fnp-3806	1187	7	are	be	AUX
fnp-3806	1187	8	involved	involve	VERB
fnp-3806	1187	9	at	at	ADP
fnp-3806	1187	10	the	the	DET
fnp-3806	1187	11	early	early	ADJ
fnp-3806	1187	12	/	/	SYM
fnp-3806	1187	13	middle	middle	ADJ
fnp-3806	1187	14	stages	stage	NOUN
fnp-3806	1187	15	of	of	ADP
fnp-3806	1187	16	ad	ad	NOUN
fnp-3806	1187	17	(	(	PUNCT
fnp-3806	1187	18	1494	1494	NUM
fnp-3806	1187	19	)	)	PUNCT
fnp-3806	1187	20	.	.	PUNCT
fnp-3806	1188	1	more	more	ADV
fnp-3806	1188	2	detailed	detailed	ADJ
fnp-3806	1188	3	studies	study	NOUN
fnp-3806	1188	4	in	in	ADP
fnp-3806	1188	5	ma	ma	PROPN
fnp-3806	1188	6	and	and	CCONJ
fnp-3806	1188	7	in	in	ADP
fnp-3806	1188	8	cases	case	NOUN
fnp-3806	1188	9	at	at	ADP
fnp-3806	1188	10	first	first	ADV
fnp-3806	1188	11	(	(	PUNCT
fnp-3806	1188	12	i	i	PROPN
fnp-3806	1188	13	-	-	PUNCT
fnp-3806	1188	14	ii	ii	PROPN
fnp-3806	1188	15	)	)	PUNCT
fnp-3806	1188	16	,	,	PUNCT
fnp-3806	1188	17	middle	middle	NOUN
fnp-3806	1188	18	(	(	PUNCT
fnp-3806	1188	19	iii	iii	X
fnp-3806	1188	20	-	-	PUNCT
fnp-3806	1188	21	iv	iv	NUM
fnp-3806	1188	22	)	)	PUNCT
fnp-3806	1188	23	,	,	PUNCT
fnp-3806	1188	24	and	and	CCONJ
fnp-3806	1188	25	advanced	advanced	ADJ
fnp-3806	1188	26	(	(	PUNCT
fnp-3806	1188	27	v	v	NOUN
fnp-3806	1188	28	-	-	PUNCT
fnp-3806	1188	29	vi	vi	NOUN
fnp-3806	1188	30	)	)	PUNCT
fnp-3806	1188	31	nft	nft	PROPN
fnp-3806	1188	32	stages	stage	NOUN
fnp-3806	1188	33	examined	examine	VERB
fnp-3806	1188	34	the	the	DET
fnp-3806	1188	35	expression	expression	NOUN
fnp-3806	1188	36	of	of	ADP
fnp-3806	1188	37	cytokines	cytokine	NOUN
fnp-3806	1188	38	and	and	CCONJ
fnp-3806	1188	39	mediators	mediator	NOUN
fnp-3806	1188	40	of	of	ADP
fnp-3806	1188	41	the	the	DET
fnp-3806	1188	42	immune	immune	ADJ
fnp-3806	1188	43	system	system	NOUN
fnp-3806	1188	44	in	in	ADP
fnp-3806	1188	45	different	different	ADJ
fnp-3806	1188	46	regions	region	NOUN
fnp-3806	1188	47	progressively	progressively	ADV
fnp-3806	1188	48	affected	affect	VERB
fnp-3806	1188	49	in	in	ADP
fnp-3806	1188	50	sad	sad	ADJ
fnp-3806	1188	51	:	:	PUNCT
fnp-3806	1188	52	the	the	DET
fnp-3806	1188	53	entorhinal	entorhinal	ADJ
fnp-3806	1188	54	cortex	cortex	NOUN
fnp-3806	1188	55	,	,	PUNCT
fnp-3806	1188	56	orbitofrontal	orbitofrontal	ADJ
fnp-3806	1188	57	cortex	cortex	NOUN
fnp-3806	1188	58	,	,	PUNCT
fnp-3806	1188	59	and	and	CCONJ
fnp-3806	1188	60	frontal	frontal	ADJ
fnp-3806	1188	61	cortex	cortex	NOUN
fnp-3806	1188	62	area	area	NOUN
fnp-3806	1188	63	8	8	NUM
fnp-3806	1188	64	(	(	PUNCT
fnp-3806	1188	65	838	838	NUM
fnp-3806	1188	66	)	)	PUNCT
fnp-3806	1188	67	.	.	PUNCT
fnp-3806	1189	1	changes	change	NOUN
fnp-3806	1189	2	in	in	ADP
fnp-3806	1189	3	mrna	mrna	NOUN
fnp-3806	1189	4	expression	expression	NOUN
fnp-3806	1189	5	correlated	correlate	VERB
fnp-3806	1189	6	with	with	ADP
fnp-3806	1189	7	the	the	DET
fnp-3806	1189	8	corresponding	corresponding	ADJ
fnp-3806	1189	9	protein	protein	NOUN
fnp-3806	1189	10	levels	level	NOUN
fnp-3806	1189	11	as	as	SCONJ
fnp-3806	1189	12	revealed	reveal	VERB
fnp-3806	1189	13	by	by	ADP
fnp-3806	1189	14	immunohistochemistry	immunohistochemistry	NOUN
fnp-3806	1189	15	and	and	CCONJ
fnp-3806	1189	16	western	western	ADJ
fnp-3806	1189	17	blotting	blotting	NOUN
fnp-3806	1189	18	(	(	PUNCT
fnp-3806	1189	19	838	838	NUM
fnp-3806	1189	20	)	)	PUNCT
fnp-3806	1189	21	.	.	PUNCT
fnp-3806	1190	1	moreover	moreover	ADV
fnp-3806	1190	2	,	,	PUNCT
fnp-3806	1190	3	gene	gene	NOUN
fnp-3806	1190	4	regulation	regulation	NOUN
fnp-3806	1190	5	at	at	ADP
fnp-3806	1190	6	first	first	ADJ
fnp-3806	1190	7	stages	stage	NOUN
fnp-3806	1190	8	of	of	ADP
fnp-3806	1190	9	ad	ad	NOUN
fnp-3806	1190	10	pathology	pathology	NOUN
fnp-3806	1190	11	(	(	PUNCT
fnp-3806	1190	12	nft	nft	PROPN
fnp-3806	1190	13	i	i	PROPN
fnp-3806	1190	14	-	-	PUNCT
fnp-3806	1190	15	ii	ii	PROPN
fnp-3806	1190	16	,	,	PUNCT
fnp-3806	1190	17	sps	sps	PROPN
fnp-3806	1190	18	:	:	PUNCT
fnp-3806	1190	19	0	0	X
fnp-3806	1190	20	)	)	PUNCT
fnp-3806	1190	21	was	be	AUX
fnp-3806	1190	22	not	not	PART
fnp-3806	1190	23	related	relate	VERB
fnp-3806	1190	24	to	to	ADP
fnp-3806	1190	25	nfts	nft	NOUN
fnp-3806	1190	26	,	,	PUNCT
fnp-3806	1190	27	β	β	NOUN
fnp-3806	1190	28	-	-	ADJ
fnp-3806	1190	29	amyloid	amyloid	ADJ
fnp-3806	1190	30	plaques	plaque	NOUN
fnp-3806	1190	31	,	,	PUNCT
fnp-3806	1190	32	concentration	concentration	NOUN
fnp-3806	1190	33	of	of	ADP
fnp-3806	1190	34	aβ40	aβ40	PROPN
fnp-3806	1190	35	and	and	CCONJ
fnp-3806	1190	36	aβ42	aβ42	PROPN
fnp-3806	1190	37	,	,	PUNCT
fnp-3806	1190	38	or	or	CCONJ
fnp-3806	1190	39	membrane	membrane	NOUN
fnp-3806	1190	40	-	-	PUNCT
fnp-3806	1190	41	bound	bind	VERB
fnp-3806	1190	42	fibrillar	fibrillar	ADJ
fnp-3806	1190	43	β	β	NOUN
fnp-3806	1190	44	-	-	NOUN
fnp-3806	1190	45	amyloid	amyloid	NOUN
fnp-3806	1190	46	in	in	ADP
fnp-3806	1190	47	the	the	DET
fnp-3806	1190	48	frontal	frontal	ADJ
fnp-3806	1190	49	cortex	cortex	NOUN
fnp-3806	1190	50	(	(	PUNCT
fnp-3806	1190	51	838	838	NUM
fnp-3806	1190	52	)	)	PUNCT
fnp-3806	1190	53	.	.	PUNCT
fnp-3806	1191	1	these	these	DET
fnp-3806	1191	2	observations	observation	NOUN
fnp-3806	1191	3	do	do	AUX
fnp-3806	1191	4	not	not	PART
fnp-3806	1191	5	contradict	contradict	VERB
fnp-3806	1191	6	previous	previous	ADJ
fnp-3806	1191	7	studies	study	NOUN
fnp-3806	1191	8	showing	show	VERB
fnp-3806	1191	9	a	a	DET
fnp-3806	1191	10	relationship	relationship	NOUN
fnp-3806	1191	11	between	between	ADP
fnp-3806	1191	12	membrane	membrane	NOUN
fnp-3806	1191	13	-	-	PUNCT
fnp-3806	1191	14	associated	associate	VERB
fnp-3806	1191	15	β	β	NOUN
fnp-3806	1191	16	-	-	NOUN
fnp-3806	1191	17	amyloid	amyloid	NOUN
fnp-3806	1191	18	and	and	CCONJ
fnp-3806	1191	19	inflammatory	inflammatory	ADJ
fnp-3806	1191	20	changes	change	NOUN
fnp-3806	1191	21	in	in	ADP
fnp-3806	1191	22	cases	case	NOUN
fnp-3806	1191	23	with	with	ADP
fnp-3806	1191	24	more	more	ADV
fnp-3806	1191	25	advanced	advanced	ADJ
fnp-3806	1191	26	preclinical	preclinical	ADJ
fnp-3806	1191	27	ad	ad	NOUN
fnp-3806	1191	28	and	and	CCONJ
fnp-3806	1191	29	sps	sps	NOUN
fnp-3806	1191	30	in	in	ADP
fnp-3806	1191	31	the	the	DET
fnp-3806	1191	32	cerebral	cerebral	ADJ
fnp-3806	1191	33	cortex	cortex	NOUN
fnp-3806	1191	34	(	(	PUNCT
fnp-3806	1191	35	101	101	NUM
fnp-3806	1191	36	)	)	PUNCT
fnp-3806	1191	37	,	,	PUNCT
fnp-3806	1191	38	but	but	CCONJ
fnp-3806	1191	39	they	they	PRON
fnp-3806	1191	40	highlight	highlight	VERB
fnp-3806	1191	41	the	the	DET
fnp-3806	1191	42	observations	observation	NOUN
fnp-3806	1191	43	that	that	PRON
fnp-3806	1191	44	:	:	PUNCT
fnp-3806	1191	45	(	(	PUNCT
fnp-3806	1191	46	a	a	X
fnp-3806	1191	47	)	)	PUNCT
fnp-3806	1191	48	inflammatory	inflammatory	ADJ
fnp-3806	1191	49	markers	marker	NOUN
fnp-3806	1191	50	appear	appear	VERB
fnp-3806	1191	51	at	at	ADP
fnp-3806	1191	52	the	the	DET
fnp-3806	1191	53	first	first	ADJ
fnp-3806	1191	54	stages	stage	NOUN
fnp-3806	1191	55	of	of	ADP
fnp-3806	1191	56	nft	nft	PROPN
fnp-3806	1191	57	pathology	pathology	PROPN
fnp-3806	1191	58	(	(	PUNCT
fnp-3806	1191	59	stages	stage	NOUN
fnp-3806	1191	60	i	i	PROPN
fnp-3806	1191	61	-	-	PUNCT
fnp-3806	1191	62	iii	iii	NOUN
fnp-3806	1191	63	)	)	PUNCT
fnp-3806	1191	64	in	in	ADP
fnp-3806	1191	65	regions	region	NOUN
fnp-3806	1191	66	with	with	ADP
fnp-3806	1191	67	no	no	DET
fnp-3806	1191	68	nfts	nft	NOUN
fnp-3806	1191	69	and	and	CCONJ
fnp-3806	1191	70	sps	sps	NOUN
fnp-3806	1191	71	;	;	PUNCT
fnp-3806	1191	72	(	(	PUNCT
fnp-3806	1191	73	b	b	X
fnp-3806	1191	74	)	)	PUNCT
fnp-3806	1191	75	inflammatory	inflammatory	ADJ
fnp-3806	1191	76	changes	change	NOUN
fnp-3806	1191	77	are	be	AUX
fnp-3806	1191	78	modified	modify	VERB
fnp-3806	1191	79	with	with	ADP
fnp-3806	1191	80	disease	disease	NOUN
fnp-3806	1191	81	progression	progression	NOUN
fnp-3806	1191	82	;	;	PUNCT
fnp-3806	1191	83	and	and	CCONJ
fnp-3806	1191	84	(	(	PUNCT
fnp-3806	1191	85	c	c	X
fnp-3806	1191	86	)	)	PUNCT
fnp-3806	1191	87	different	different	ADJ
fnp-3806	1191	88	inflammatory	inflammatory	ADJ
fnp-3806	1191	89	responses	response	NOUN
fnp-3806	1191	90	occur	occur	VERB
fnp-3806	1191	91	simultaneously	simultaneously	ADV
fnp-3806	1191	92	in	in	ADP
fnp-3806	1191	93	different	different	ADJ
fnp-3806	1191	94	regions	region	NOUN
fnp-3806	1191	95	in	in	ADP
fnp-3806	1191	96	the	the	DET
fnp-3806	1191	97	same	same	ADJ
fnp-3806	1191	98	individual	individual	NOUN
fnp-3806	1191	99	.	.	PUNCT
fnp-3806	1192	1	22	22	NUM
fnp-3806	1192	2	g.	g.	NOUN
fnp-3806	1192	3	protein	protein	NOUN
fnp-3806	1192	4	synthesis	synthesis	NOUN
fnp-3806	1192	5	impairment	impairment	NOUN
fnp-3806	1192	6	protein	protein	NOUN
fnp-3806	1192	7	synthesis	synthesis	NOUN
fnp-3806	1192	8	is	be	AUX
fnp-3806	1192	9	altered	alter	VERB
fnp-3806	1192	10	in	in	ADP
fnp-3806	1192	11	sad	sad	ADJ
fnp-3806	1192	12	,	,	PUNCT
fnp-3806	1192	13	and	and	CCONJ
fnp-3806	1192	14	this	this	PRON
fnp-3806	1192	15	is	be	AUX
fnp-3806	1192	16	due	due	ADJ
fnp-3806	1192	17	to	to	ADP
fnp-3806	1192	18	multiple	multiple	ADJ
fnp-3806	1192	19	alterations	alteration	NOUN
fnp-3806	1192	20	at	at	ADP
fnp-3806	1192	21	different	different	ADJ
fnp-3806	1192	22	subcellular	subcellular	ADJ
fnp-3806	1192	23	levels	level	NOUN
fnp-3806	1192	24	from	from	ADP
fnp-3806	1192	25	the	the	DET
fnp-3806	1192	26	nucleolus	nucleolus	NOUN
fnp-3806	1192	27	to	to	ADP
fnp-3806	1192	28	the	the	DET
fnp-3806	1192	29	ribosome	ribosome	NOUN
fnp-3806	1192	30	.	.	PUNCT
fnp-3806	1193	1	the	the	DET
fnp-3806	1193	2	relation	relation	NOUN
fnp-3806	1193	3	nuclear	nuclear	ADJ
fnp-3806	1193	4	organizer	organizer	NOUN
fnp-3806	1193	5	region	region	NOUN
fnp-3806	1193	6	(	(	PUNCT
fnp-3806	1193	7	nor	nor	CCONJ
fnp-3806	1193	8	)	)	PUNCT
fnp-3806	1193	9	surface	surface	NOUN
fnp-3806	1193	10	/	/	SYM
fnp-3806	1193	11	total	total	ADJ
fnp-3806	1193	12	nucleus	nucleus	PROPN
fnp-3806	1193	13	surface	surface	NOUN
fnp-3806	1193	14	is	be	AUX
fnp-3806	1193	15	reduced	reduce	VERB
fnp-3806	1193	16	;	;	PUNCT
fnp-3806	1193	17	the	the	DET
fnp-3806	1193	18	rdna	rdna	NOUN
fnp-3806	1193	19	promoter	promoter	NOUN
fnp-3806	1193	20	is	be	AUX
fnp-3806	1193	21	hyper	hyper	ADV
fnp-3806	1193	22	-	-	ADJ
fnp-3806	1193	23	methylated	methylate	VERB
fnp-3806	1193	24	,	,	PUNCT
fnp-3806	1193	25	and	and	CCONJ
fnp-3806	1193	26	dimethylated	dimethylate	VERB
fnp-3806	1193	27	histone	histone	PROPN
fnp-3806	1193	28	h3k9	h3k9	PROPN
fnp-3806	1193	29	and	and	CCONJ
fnp-3806	1193	30	acetylated	acetylate	VERB
fnp-3806	1193	31	histone	histone	NOUN
fnp-3806	1193	32	h3k12	h3k12	NOUN
fnp-3806	1193	33	are	be	AUX
fnp-3806	1193	34	decreased	decrease	VERB
fnp-3806	1193	35	in	in	ADP
fnp-3806	1193	36	the	the	DET
fnp-3806	1193	37	ca1	ca1	PROPN
fnp-3806	1193	38	region	region	NOUN
fnp-3806	1193	39	of	of	ADP
fnp-3806	1193	40	the	the	DET
fnp-3806	1193	41	hippocampus	hippocampus	NOUN
fnp-3806	1193	42	;	;	PUNCT
fnp-3806	1193	43	nuclear	nuclear	ADJ
fnp-3806	1193	44	tau	tau	PROPN
fnp-3806	1193	45	declines	decline	VERB
fnp-3806	1193	46	;	;	PUNCT
fnp-3806	1193	47	specific	specific	ADJ
fnp-3806	1193	48	transcription	transcription	NOUN
fnp-3806	1193	49	factors	factor	NOUN
fnp-3806	1193	50	are	be	AUX
fnp-3806	1193	51	abnormally	abnormally	ADV
fnp-3806	1193	52	regulated	regulate	VERB
fnp-3806	1193	53	;	;	PUNCT
fnp-3806	1193	54	rrna	rrna	PROPN
fnp-3806	1193	55	levels	level	NOUN
fnp-3806	1193	56	are	be	AUX
fnp-3806	1193	57	decreased	decrease	VERB
fnp-3806	1193	58	and	and	CCONJ
fnp-3806	1193	59	rna	rna	NOUN
fnp-3806	1193	60	is	be	AUX
fnp-3806	1193	61	oxidatively	oxidatively	ADV
fnp-3806	1193	62	damaged	damage	VERB
fnp-3806	1193	63	;	;	PUNCT
fnp-3806	1193	64	the	the	DET
fnp-3806	1193	65	expression	expression	NOUN
fnp-3806	1193	66	of	of	ADP
fnp-3806	1193	67	nucleolar	nucleolar	ADJ
fnp-3806	1193	68	proteins	protein	NOUN
fnp-3806	1193	69	as	as	ADV
fnp-3806	1193	70	well	well	ADV
fnp-3806	1193	71	as	as	ADP
fnp-3806	1193	72	the	the	DET
fnp-3806	1193	73	expression	expression	NOUN
fnp-3806	1193	74	of	of	ADP
fnp-3806	1193	75	rnas	rna	NOUN
fnp-3806	1193	76	involved	involve	VERB
fnp-3806	1193	77	in	in	ADP
fnp-3806	1193	78	the	the	DET
fnp-3806	1193	79	generation	generation	NOUN
fnp-3806	1193	80	of	of	ADP
fnp-3806	1193	81	ribosomal	ribosomal	NOUN
fnp-3806	1193	82	proteins	protein	NOUN
fnp-3806	1193	83	decreases	decrease	VERB
fnp-3806	1193	84	;	;	PUNCT
fnp-3806	1193	85	the	the	DET
fnp-3806	1193	86	expression	expression	NOUN
fnp-3806	1193	87	levels	level	NOUN
fnp-3806	1193	88	of	of	ADP
fnp-3806	1193	89	translation	translation	NOUN
fnp-3806	1193	90	initiation	initiation	NOUN
fnp-3806	1193	91	and	and	CCONJ
fnp-3806	1193	92	elongation	elongation	NOUN
fnp-3806	1193	93	factor	factor	NOUN
fnp-3806	1193	94	of	of	ADP
fnp-3806	1193	95	the	the	DET
fnp-3806	1193	96	protein	protein	NOUN
fnp-3806	1193	97	synthesis	synthesis	NOUN
fnp-3806	1193	98	in	in	ADP
fnp-3806	1193	99	ribosomes	ribosome	NOUN
fnp-3806	1193	100	is	be	AUX
fnp-3806	1193	101	dysregulated	dysregulate	VERB
fnp-3806	1193	102	;	;	PUNCT
fnp-3806	1193	103	and	and	CCONJ
fnp-3806	1193	104	the	the	DET
fnp-3806	1193	105	capacity	capacity	NOUN
fnp-3806	1193	106	of	of	ADP
fnp-3806	1193	107	isolated	isolated	ADJ
fnp-3806	1193	108	ribosomes	ribosome	NOUN
fnp-3806	1193	109	to	to	PART
fnp-3806	1193	110	incorporate	incorporate	VERB
fnp-3806	1193	111	s35	s35	NOUN
fnp-3806	1193	112	methionine	methionine	NOUN
fnp-3806	1193	113	into	into	ADP
fnp-3806	1193	114	protein	protein	NOUN
fnp-3806	1193	115	is	be	AUX
fnp-3806	1193	116	impaired	impair	VERB
fnp-3806	1193	117	(	(	PUNCT
fnp-3806	1193	118	1010	1010	NUM
fnp-3806	1193	119	,	,	PUNCT
fnp-3806	1193	120	1473	1473	NUM
fnp-3806	1193	121	,	,	PUNCT
fnp-3806	1193	122	1495	1495	NUM
fnp-3806	1193	123	-	-	SYM
fnp-3806	1193	124	1506	1506	NUM
fnp-3806	1193	125	)	)	PUNCT
fnp-3806	1193	126	.	.	PUNCT
fnp-3806	1194	1	tau	tau	PROPN
fnp-3806	1194	2	protein	protein	NOUN
fnp-3806	1194	3	disrupts	disrupt	VERB
fnp-3806	1194	4	nucleocytoplasmic	nucleocytoplasmic	ADJ
fnp-3806	1194	5	transport	transport	NOUN
fnp-3806	1194	6	in	in	ADP
fnp-3806	1194	7	ad	ad	NOUN
fnp-3806	1194	8	(	(	PUNCT
fnp-3806	1194	9	1507	1507	NUM
fnp-3806	1194	10	)	)	PUNCT
fnp-3806	1194	11	,	,	PUNCT
fnp-3806	1194	12	but	but	CCONJ
fnp-3806	1194	13	the	the	DET
fnp-3806	1194	14	role	role	NOUN
fnp-3806	1194	15	of	of	ADP
fnp-3806	1194	16	tau	tau	PROPN
fnp-3806	1194	17	,	,	PUNCT
fnp-3806	1194	18	if	if	SCONJ
fnp-3806	1194	19	any	any	PRON
fnp-3806	1194	20	,	,	PUNCT
fnp-3806	1194	21	in	in	ADP
fnp-3806	1194	22	the	the	DET
fnp-3806	1194	23	other	other	ADJ
fnp-3806	1194	24	steps	step	NOUN
fnp-3806	1194	25	of	of	ADP
fnp-3806	1194	26	the	the	DET
fnp-3806	1194	27	protein	protein	NOUN
fnp-3806	1194	28	synthesis	synthesis	NOUN
fnp-3806	1194	29	pathway	pathway	NOUN
fnp-3806	1194	30	is	be	AUX
fnp-3806	1194	31	not	not	PART
fnp-3806	1194	32	known	know	VERB
fnp-3806	1194	33	.	.	PUNCT
fnp-3806	1195	1	alterations	alteration	NOUN
fnp-3806	1195	2	of	of	ADP
fnp-3806	1195	3	protein	protein	NOUN
fnp-3806	1195	4	synthesis	synthesis	NOUN
fnp-3806	1195	5	pathways	pathway	NOUN
fnp-3806	1195	6	are	be	AUX
fnp-3806	1195	7	already	already	ADV
fnp-3806	1195	8	identified	identify	VERB
fnp-3806	1195	9	in	in	ADP
fnp-3806	1195	10	the	the	DET
fnp-3806	1195	11	hippocampus	hippocampus	NOUN
fnp-3806	1195	12	at	at	ADP
fnp-3806	1195	13	the	the	DET
fnp-3806	1195	14	first	first	ADJ
fnp-3806	1195	15	stages	stage	NOUN
fnp-3806	1195	16	of	of	ADP
fnp-3806	1195	17	nft	nft	PROPN
fnp-3806	1195	18	pathology	pathology	PROPN
fnp-3806	1195	19	.	.	PUNCT
fnp-3806	1196	1	nucleophosmin	nucleophosmin	NOUN
fnp-3806	1196	2	1	1	NUM
fnp-3806	1196	3	(	(	PUNCT
fnp-3806	1196	4	npm1	npm1	PROPN
fnp-3806	1196	5	)	)	PUNCT
fnp-3806	1196	6	mrna	mrna	PROPN
fnp-3806	1196	7	is	be	AUX
fnp-3806	1196	8	significantly	significantly	ADV
fnp-3806	1196	9	increased	increase	VERB
fnp-3806	1196	10	,	,	PUNCT
fnp-3806	1196	11	and	and	CCONJ
fnp-3806	1196	12	upstream	upstream	ADJ
fnp-3806	1196	13	binding	bind	VERB
fnp-3806	1196	14	transcription	transcription	NOUN
fnp-3806	1196	15	factor	factor	NOUN
fnp-3806	1196	16	rna	rna	NOUN
fnp-3806	1196	17	polymerase	polymerase	NOUN
fnp-3806	1197	1	i	i	PRON
fnp-3806	1197	2	gene	gene	NOUN
fnp-3806	1197	3	(	(	PUNCT
fnp-3806	1197	4	ubtf	ubtf	PROPN
fnp-3806	1197	5	)	)	PUNCT
fnp-3806	1197	6	mrna	mrna	PROPN
fnp-3806	1197	7	and	and	CCONJ
fnp-3806	1197	8	28s	28	NOUN
fnp-3806	1197	9	rrna	rrna	PROPN
fnp-3806	1197	10	significantly	significantly	ADV
fnp-3806	1197	11	decreased	decrease	VERB
fnp-3806	1197	12	in	in	ADP
fnp-3806	1197	13	ca1	ca1	PROPN
fnp-3806	1197	14	,	,	PUNCT
fnp-3806	1197	15	but	but	CCONJ
fnp-3806	1197	16	not	not	PART
fnp-3806	1197	17	in	in	ADP
fnp-3806	1197	18	the	the	DET
fnp-3806	1197	19	dentate	dentate	ADJ
fnp-3806	1197	20	gyrus	gyrus	NOUN
fnp-3806	1197	21	at	at	ADP
fnp-3806	1197	22	nft	nft	PROPN
fnp-3806	1197	23	stages	stage	NOUN
fnp-3806	1197	24	i	i	PROPN
fnp-3806	1197	25	-	-	PUNCT
fnp-3806	1197	26	ii	ii	PROPN
fnp-3806	1197	27	.	.	PROPN
fnp-3806	1197	28	dimethylated	dimethylate	VERB
fnp-3806	1197	29	histone	histone	PROPN
fnp-3806	1197	30	h3k9	h3k9	PROPN
fnp-3806	1197	31	(	(	PUNCT
fnp-3806	1197	32	h3k9m2	h3k9m2	PROPN
fnp-3806	1197	33	)	)	PUNCT
fnp-3806	1197	34	immunoreactivity	immunoreactivity	NOUN
fnp-3806	1197	35	is	be	AUX
fnp-3806	1197	36	reduced	reduce	VERB
fnp-3806	1197	37	in	in	ADP
fnp-3806	1197	38	neurons	neuron	NOUN
fnp-3806	1197	39	of	of	ADP
fnp-3806	1197	40	the	the	DET
fnp-3806	1197	41	dentate	dentate	ADJ
fnp-3806	1197	42	gyrus	gyrus	NOUN
fnp-3806	1197	43	and	and	CCONJ
fnp-3806	1197	44	ca1	ca1	NOUN
fnp-3806	1197	45	at	at	ADP
fnp-3806	1197	46	nft	nft	PROPN
fnp-3806	1197	47	stages	stage	NOUN
fnp-3806	1197	48	i	i	PROPN
fnp-3806	1197	49	-	-	PUNCT
fnp-3806	1197	50	ii	ii	PROPN
fnp-3806	1197	51	.	.	PUNCT
fnp-3806	1198	1	mrna	mrna	PROPN
fnp-3806	1198	2	expression	expression	NOUN
fnp-3806	1198	3	of	of	ADP
fnp-3806	1198	4	ribosomal	ribosomal	NOUN
fnp-3806	1198	5	proteins	protein	NOUN
fnp-3806	1198	6	rpl23a	rpl23a	NOUN
fnp-3806	1198	7	,	,	PUNCT
fnp-3806	1198	8	rpl26	rpl26	VERB
fnp-3806	1198	9	,	,	PUNCT
fnp-3806	1198	10	rpl31rps5	rpl31rps5	PROPN
fnp-3806	1198	11	,	,	PUNCT
fnp-3806	1198	12	rps6	rps6	NOUN
fnp-3806	1198	13	,	,	PUNCT
fnp-3806	1198	14	rps10	rps10	ADJ
fnp-3806	1198	15	,	,	PUNCT
fnp-3806	1198	16	and	and	CCONJ
fnp-3806	1198	17	rps13	rps13	NOUN
fnp-3806	1198	18	is	be	AUX
fnp-3806	1198	19	significantly	significantly	ADV
fnp-3806	1198	20	reduced	reduce	VERB
fnp-3806	1198	21	in	in	ADP
fnp-3806	1198	22	the	the	DET
fnp-3806	1198	23	dentate	dentate	ADJ
fnp-3806	1198	24	gyrus	gyrus	NOUN
fnp-3806	1198	25	at	at	ADP
fnp-3806	1198	26	stages	stage	NOUN
fnp-3806	1198	27	i	i	PROPN
fnp-3806	1198	28	-	-	PUNCT
fnp-3806	1198	29	ii	ii	PROPN
fnp-3806	1198	30	when	when	SCONJ
fnp-3806	1198	31	compared	compare	VERB
fnp-3806	1198	32	with	with	ADP
fnp-3806	1198	33	ma	ma	PROPN
fnp-3806	1198	34	individuals	individual	NOUN
fnp-3806	1198	35	without	without	ADP
fnp-3806	1198	36	nft	nft	PROPN
fnp-3806	1198	37	pathology	pathology	PROPN
fnp-3806	1198	38	.	.	PUNCT
fnp-3806	1199	1	in	in	ADP
fnp-3806	1199	2	contrast	contrast	NOUN
fnp-3806	1199	3	,	,	PUNCT
fnp-3806	1199	4	rpl5	rpl5	NOUN
fnp-3806	1199	5	and	and	CCONJ
fnp-3806	1199	6	rpl26	rpl26	VERB
fnp-3806	1199	7	mrna	mrna	PROPN
fnp-3806	1199	8	expression	expression	NOUN
fnp-3806	1199	9	is	be	AUX
fnp-3806	1199	10	increased	increase	VERB
fnp-3806	1199	11	,	,	PUNCT
fnp-3806	1199	12	and	and	CCONJ
fnp-3806	1199	13	rps5	rps5	NOUN
fnp-3806	1199	14	and	and	CCONJ
fnp-3806	1199	15	rps6	rps6	PROPN
fnp-3806	1199	16	mrna	mrna	PROPN
fnp-3806	1199	17	decreased	decrease	VERB
fnp-3806	1199	18	in	in	ADP
fnp-3806	1199	19	ca1	ca1	PROPN
fnp-3806	1199	20	at	at	ADP
fnp-3806	1199	21	the	the	DET
fnp-3806	1199	22	same	same	ADJ
fnp-3806	1199	23	stages	stage	NOUN
fnp-3806	1199	24	i	i	PROPN
fnp-3806	1199	25	-	-	PUNCT
fnp-3806	1199	26	ii	ii	PROPN
fnp-3806	1199	27	(	(	PUNCT
fnp-3806	1199	28	1508	1508	NUM
fnp-3806	1199	29	)	)	PUNCT
fnp-3806	1199	30	.	.	PUNCT
fnp-3806	1200	1	these	these	DET
fnp-3806	1200	2	results	result	NOUN
fnp-3806	1200	3	show	show	VERB
fnp-3806	1200	4	early	early	ADJ
fnp-3806	1200	5	alterations	alteration	NOUN
fnp-3806	1200	6	not	not	PART
fnp-3806	1200	7	only	only	ADV
fnp-3806	1200	8	in	in	ADP
fnp-3806	1200	9	the	the	DET
fnp-3806	1200	10	ca1	ca1	PROPN
fnp-3806	1200	11	region	region	NOUN
fnp-3806	1200	12	,	,	PUNCT
fnp-3806	1200	13	which	which	PRON
fnp-3806	1200	14	will	will	AUX
fnp-3806	1200	15	be	be	AUX
fnp-3806	1200	16	involved	involve	VERB
fnp-3806	1200	17	in	in	ADP
fnp-3806	1200	18	nft	nft	PROPN
fnp-3806	1200	19	pathology	pathology	PROPN
fnp-3806	1200	20	,	,	PUNCT
fnp-3806	1200	21	but	but	CCONJ
fnp-3806	1200	22	also	also	ADV
fnp-3806	1200	23	in	in	ADP
fnp-3806	1200	24	the	the	DET
fnp-3806	1200	25	dentate	dentate	ADJ
fnp-3806	1200	26	gyrus	gyrus	NOUN
fnp-3806	1200	27	,	,	PUNCT
fnp-3806	1200	28	which	which	PRON
fnp-3806	1200	29	does	do	AUX
fnp-3806	1200	30	not	not	PART
fnp-3806	1200	31	contain	contain	VERB
fnp-3806	1200	32	abnormal	abnormal	ADJ
fnp-3806	1200	33	tau	tau	NOUN
fnp-3806	1200	34	deposits	deposit	NOUN
fnp-3806	1200	35	at	at	ADP
fnp-3806	1200	36	any	any	DET
fnp-3806	1200	37	time	time	NOUN
fnp-3806	1200	38	in	in	ADP
fnp-3806	1200	39	the	the	DET
fnp-3806	1200	40	process	process	NOUN
fnp-3806	1200	41	.	.	PUNCT
fnp-3806	1201	1	seven	seven	NUM
fnp-3806	1201	2	upregulated	upregulated	ADJ
fnp-3806	1201	3	mirnas	mirna	NOUN
fnp-3806	1201	4	(	(	PUNCT
fnp-3806	1201	5	mir-125b	mir-125b	NOUN
fnp-3806	1201	6	,	,	PUNCT
fnp-3806	1201	7	mir-146a	mir-146a	ADJ
fnp-3806	1201	8	,	,	PUNCT
fnp-3806	1201	9	mir-200c	mir-200c	NOUN
fnp-3806	1201	10	,	,	PUNCT
fnp-3806	1201	11	mir-26b	mir-26b	NOUN
fnp-3806	1201	12	,	,	PUNCT
fnp-3806	1201	13	mir-30e	mir-30e	NUM
fnp-3806	1201	14	,	,	PUNCT
fnp-3806	1201	15	mir-34a	mir-34a	NOUN
fnp-3806	1201	16	,	,	PUNCT
fnp-3806	1201	17	and	and	CCONJ
fnp-3806	1201	18	mir-34c	mir-34c	NUM
fnp-3806	1201	19	)	)	PUNCT
fnp-3806	1201	20	and	and	CCONJ
fnp-3806	1201	21	three	three	NUM
fnp-3806	1201	22	downregulated	downregulate	VERB
fnp-3806	1201	23	mirnas	mirna	NOUN
fnp-3806	1201	24	(	(	PUNCT
fnp-3806	1201	25	mir-107	mir-107	PROPN
fnp-3806	1201	26	,	,	PUNCT
fnp-3806	1201	27	mir-210	mir-210	NOUN
fnp-3806	1201	28	,	,	PUNCT
fnp-3806	1201	29	and	and	CCONJ
fnp-3806	1201	30	mir-485	mir-485	NOUN
fnp-3806	1201	31	)	)	PUNCT
fnp-3806	1201	32	,	,	PUNCT
fnp-3806	1201	33	all	all	PRON
fnp-3806	1201	34	of	of	ADP
fnp-3806	1201	35	which	which	PRON
fnp-3806	1201	36	associated	associate	VERB
fnp-3806	1201	37	with	with	ADP
fnp-3806	1201	38	oxidative	oxidative	ADJ
fnp-3806	1201	39	stress	stress	NOUN
fnp-3806	1201	40	,	,	PUNCT
fnp-3806	1201	41	are	be	AUX
fnp-3806	1201	42	found	find	VERB
fnp-3806	1201	43	in	in	ADP
fnp-3806	1201	44	vulnerable	vulnerable	ADJ
fnp-3806	1201	45	brain	brain	NOUN
fnp-3806	1201	46	regions	region	NOUN
fnp-3806	1201	47	of	of	ADP
fnp-3806	1201	48	sad	sad	ADJ
fnp-3806	1201	49	at	at	ADP
fnp-3806	1201	50	the	the	DET
fnp-3806	1201	51	clinical	clinical	ADJ
fnp-3806	1201	52	prodromal	prodromal	ADJ
fnp-3806	1201	53	stage	stage	NOUN
fnp-3806	1201	54	(	(	PUNCT
fnp-3806	1201	55	1501	1501	NUM
fnp-3806	1201	56	)	)	PUNCT
fnp-3806	1201	57	.	.	PUNCT
fnp-3806	1202	1	together	together	ADV
fnp-3806	1202	2	,	,	PUNCT
fnp-3806	1202	3	these	these	DET
fnp-3806	1202	4	observations	observation	NOUN
fnp-3806	1202	5	show	show	VERB
fnp-3806	1202	6	that	that	SCONJ
fnp-3806	1202	7	alterations	alteration	NOUN
fnp-3806	1202	8	in	in	ADP
fnp-3806	1202	9	protein	protein	NOUN
fnp-3806	1202	10	synthesis	synthesis	NOUN
fnp-3806	1202	11	pathways	pathway	NOUN
fnp-3806	1202	12	appear	appear	VERB
fnp-3806	1202	13	at	at	ADP
fnp-3806	1202	14	early	early	ADJ
fnp-3806	1202	15	stages	stage	NOUN
fnp-3806	1202	16	of	of	ADP
fnp-3806	1202	17	ad	ad	NOUN
fnp-3806	1202	18	-	-	PUNCT
fnp-3806	1202	19	related	relate	VERB
fnp-3806	1202	20	pathology	pathology	NOUN
fnp-3806	1202	21	and	and	CCONJ
fnp-3806	1202	22	they	they	PRON
fnp-3806	1202	23	are	be	AUX
fnp-3806	1202	24	not	not	PART
fnp-3806	1202	25	linked	link	VERB
fnp-3806	1202	26	to	to	ADP
fnp-3806	1202	27	tau	tau	PROPN
fnp-3806	1202	28	and	and	CCONJ
fnp-3806	1202	29	β	β	NOUN
fnp-3806	1202	30	-	-	ADJ
fnp-3806	1202	31	amyloid	amyloid	ADJ
fnp-3806	1202	32	deposits	deposit	NOUN
fnp-3806	1202	33	.	.	PUNCT
fnp-3806	1203	1	disruption	disruption	NOUN
fnp-3806	1203	2	at	at	ADP
fnp-3806	1203	3	many	many	ADJ
fnp-3806	1203	4	steps	step	NOUN
fnp-3806	1203	5	of	of	ADP
fnp-3806	1203	6	the	the	DET
fnp-3806	1203	7	protein	protein	NOUN
fnp-3806	1203	8	synthesis	synthesis	NOUN
fnp-3806	1203	9	pathway	pathway	NOUN
fnp-3806	1203	10	increases	increase	VERB
fnp-3806	1203	11	in	in	ADP
fnp-3806	1203	12	all	all	DET
fnp-3806	1203	13	regions	region	NOUN
fnp-3806	1203	14	with	with	ADP
fnp-3806	1203	15	sad	sad	ADJ
fnp-3806	1203	16	progression	progression	NOUN
fnp-3806	1203	17	(	(	PUNCT
fnp-3806	1203	18	1508	1508	NUM
fnp-3806	1203	19	)	)	PUNCT
fnp-3806	1203	20	,	,	PUNCT
fnp-3806	1203	21	making	make	VERB
fnp-3806	1203	22	it	it	PRON
fnp-3806	1203	23	difficult	difficult	ADJ
fnp-3806	1203	24	to	to	PART
fnp-3806	1203	25	establish	establish	VERB
fnp-3806	1203	26	a	a	DET
fnp-3806	1203	27	causative	causative	ADJ
fnp-3806	1203	28	relationship	relationship	NOUN
fnp-3806	1203	29	between	between	ADP
fnp-3806	1203	30	tau	tau	PROPN
fnp-3806	1203	31	and	and	CCONJ
fnp-3806	1203	32	β	β	NOUN
fnp-3806	1203	33	-	-	ADJ
fnp-3806	1203	34	amyloid	amyloid	ADJ
fnp-3806	1203	35	pathology	pathology	NOUN
fnp-3806	1203	36	and	and	CCONJ
fnp-3806	1203	37	the	the	DET
fnp-3806	1203	38	progressive	progressive	ADJ
fnp-3806	1203	39	decay	decay	NOUN
fnp-3806	1203	40	of	of	ADP
fnp-3806	1203	41	protein	protein	NOUN
fnp-3806	1203	42	synthesis	synthesis	NOUN
fnp-3806	1203	43	at	at	ADP
fnp-3806	1203	44	advanced	advanced	ADJ
fnp-3806	1203	45	stages	stage	NOUN
fnp-3806	1203	46	of	of	ADP
fnp-3806	1203	47	sad	sad	ADJ
fnp-3806	1203	48	.	.	PUNCT
fnp-3806	1203	49	22h	22h	NOUN
fnp-3806	1203	50	.	.	PUNCT
fnp-3806	1204	1	dysregulated	dysregulate	VERB
fnp-3806	1204	2	protein	protein	NOUN
fnp-3806	1204	3	phosphorylation	phosphorylation	NOUN
fnp-3806	1204	4	early	early	ADJ
fnp-3806	1204	5	phosphoproteomics	phosphoproteomic	NOUN
fnp-3806	1204	6	studies	study	NOUN
fnp-3806	1204	7	identified	identify	VERB
fnp-3806	1204	8	a	a	DET
fnp-3806	1204	9	few	few	ADJ
fnp-3806	1204	10	abnormally	abnormally	ADV
fnp-3806	1204	11	phosphorylated	phosphorylate	VERB
fnp-3806	1204	12	proteins	protein	NOUN
fnp-3806	1204	13	in	in	ADP
fnp-3806	1204	14	the	the	DET
fnp-3806	1204	15	hippocampus	hippocampus	NOUN
fnp-3806	1204	16	and	and	CCONJ
fnp-3806	1204	17	cerebral	cerebral	ADJ
fnp-3806	1204	18	cortex	cortex	NOUN
fnp-3806	1204	19	in	in	ADP
fnp-3806	1204	20	small	small	ADJ
fnp-3806	1204	21	numbers	number	NOUN
fnp-3806	1204	22	of	of	ADP
fnp-3806	1204	23	cases	case	NOUN
fnp-3806	1204	24	with	with	ADP
fnp-3806	1204	25	sad	sad	ADJ
fnp-3806	1204	26	compared	compare	VERB
fnp-3806	1204	27	with	with	ADP
fnp-3806	1204	28	controls	control	NOUN
fnp-3806	1204	29	(	(	PUNCT
fnp-3806	1204	30	1509	1509	NUM
fnp-3806	1204	31	-	-	SYM
fnp-3806	1204	32	1511	1511	NUM
fnp-3806	1204	33	)	)	PUNCT
fnp-3806	1204	34	.	.	PUNCT
fnp-3806	1205	1	subsequent	subsequent	ADJ
fnp-3806	1205	2	work	work	NOUN
fnp-3806	1205	3	with	with	ADP
fnp-3806	1205	4	more	more	ADV
fnp-3806	1205	5	accurate	accurate	ADJ
fnp-3806	1205	6	methods	method	NOUN
fnp-3806	1205	7	in	in	ADP
fnp-3806	1205	8	advanced	advanced	ADJ
fnp-3806	1205	9	sad	sad	ADJ
fnp-3806	1205	10	identified	identify	VERB
fnp-3806	1205	11	a	a	DET
fnp-3806	1205	12	large	large	ADJ
fnp-3806	1205	13	number	number	NOUN
fnp-3806	1205	14	of	of	ADP
fnp-3806	1205	15	abnormally	abnormally	ADV
fnp-3806	1205	16	phosphorylated	phosphorylate	VERB
fnp-3806	1205	17	proteins	protein	NOUN
fnp-3806	1205	18	,	,	PUNCT
fnp-3806	1205	19	some	some	PRON
fnp-3806	1205	20	of	of	ADP
fnp-3806	1205	21	them	they	PRON
fnp-3806	1205	22	with	with	ADP
fnp-3806	1205	23	increased	increase	VERB
fnp-3806	1205	24	phosphorylation	phosphorylation	NOUN
fnp-3806	1205	25	,	,	PUNCT
fnp-3806	1205	26	and	and	CCONJ
fnp-3806	1205	27	others	other	NOUN
fnp-3806	1205	28	with	with	ADP
fnp-3806	1205	29	decreased	decrease	VERB
fnp-3806	1205	30	phosphorylation	phosphorylation	NOUN
fnp-3806	1205	31	.	.	PUNCT
fnp-3806	1206	1	abnormally	abnormally	ADV
fnp-3806	1206	2	phosphorylated	phosphorylate	VERB
fnp-3806	1206	3	proteins	protein	NOUN
fnp-3806	1206	4	corresponded	correspond	VERB
fnp-3806	1206	5	to	to	ADP
fnp-3806	1206	6	cytoskeletal	cytoskeletal	ADJ
fnp-3806	1206	7	proteins	protein	NOUN
fnp-3806	1206	8	,	,	PUNCT
fnp-3806	1206	9	integral	integral	ADJ
fnp-3806	1206	10	membrane	membrane	NOUN
fnp-3806	1206	11	proteins	protein	NOUN
fnp-3806	1206	12	,	,	PUNCT
fnp-3806	1206	13	synaptic	synaptic	ADJ
fnp-3806	1206	14	proteins	protein	NOUN
fnp-3806	1206	15	,	,	PUNCT
fnp-3806	1206	16	adhesion	adhesion	NOUN
fnp-3806	1206	17	molecules	molecule	NOUN
fnp-3806	1206	18	,	,	PUNCT
fnp-3806	1206	19	serine	serine	NOUN
fnp-3806	1206	20	/	/	SYM
fnp-3806	1206	21	threonine	threonine	ADJ
fnp-3806	1206	22	kinases	kinase	NOUN
fnp-3806	1206	23	,	,	PUNCT
fnp-3806	1206	24	transport	transport	NOUN
fnp-3806	1206	25	/	/	SYM
fnp-3806	1206	26	cargo	cargo	NOUN
fnp-3806	1206	27	proteins	protein	NOUN
fnp-3806	1206	28	,	,	PUNCT
fnp-3806	1206	29	heat	heat	NOUN
fnp-3806	1206	30	-	-	PUNCT
fnp-3806	1206	31	shock	shock	NOUN
fnp-3806	1206	32	proteins	protein	NOUN
fnp-3806	1206	33	,	,	PUNCT
fnp-3806	1206	34	and	and	CCONJ
fnp-3806	1206	35	others	other	NOUN
fnp-3806	1206	36	mostly	mostly	ADV
fnp-3806	1206	37	involved	involve	VERB
fnp-3806	1206	38	in	in	ADP
fnp-3806	1206	39	cell	cell	NOUN
fnp-3806	1206	40	growth	growth	NOUN
fnp-3806	1206	41	and/or	and/or	CCONJ
fnp-3806	1206	42	maintenance	maintenance	NOUN
fnp-3806	1206	43	,	,	PUNCT
fnp-3806	1206	44	cell	cell	NOUN
fnp-3806	1206	45	communication	communication	NOUN
fnp-3806	1206	46	,	,	PUNCT
fnp-3806	1206	47	and	and	CCONJ
fnp-3806	1206	48	metabolism	metabolism	NOUN
fnp-3806	1206	49	(	(	PUNCT
fnp-3806	1206	50	1417	1417	NUM
fnp-3806	1206	51	,	,	PUNCT
fnp-3806	1206	52	1513	1513	NUM
fnp-3806	1206	53	,	,	PUNCT
fnp-3806	1206	54	1514	1514	NUM
fnp-3806	1206	55	)	)	PUNCT
fnp-3806	1206	56	.	.	PUNCT
fnp-3806	1207	1	multi	multi	ADJ
fnp-3806	1207	2	-	-	ADJ
fnp-3806	1207	3	omics	omics	ADJ
fnp-3806	1207	4	integration	integration	NOUN
fnp-3806	1207	5	highlighted	highlight	VERB
fnp-3806	1207	6	relevant	relevant	ADJ
fnp-3806	1207	7	altered	alter	VERB
fnp-3806	1207	8	networks	network	NOUN
fnp-3806	1207	9	including	include	VERB
fnp-3806	1207	10	amyloid	amyloid	NOUN
fnp-3806	1207	11	cascade	cascade	NOUN
fnp-3806	1207	12	,	,	PUNCT
fnp-3806	1207	13	inflammation	inflammation	NOUN
fnp-3806	1207	14	,	,	PUNCT
fnp-3806	1207	15	complement	complement	NOUN
fnp-3806	1207	16	,	,	PUNCT
fnp-3806	1207	17	wnt	wnt	PROPN
fnp-3806	1207	18	protein	protein	NOUN
fnp-3806	1207	19	signaling	signal	VERB
fnp-3806	1207	20	,	,	PUNCT
fnp-3806	1207	21	transforming	transform	VERB
fnp-3806	1207	22	growth	growth	NOUN
fnp-3806	1207	23	factor	factor	NOUN
fnp-3806	1207	24	-	-	PUNCT
fnp-3806	1207	25	β	β	X
fnp-3806	1207	26	and	and	CCONJ
fnp-3806	1207	27	bone	bone	NOUN
fnp-3806	1207	28	morphogenic	morphogenic	ADJ
fnp-3806	1207	29	protein	protein	NOUN
fnp-3806	1207	30	signaling	signal	VERB
fnp-3806	1207	31	,	,	PUNCT
fnp-3806	1207	32	lipid	lipid	ADJ
fnp-3806	1207	33	metabolism	metabolism	NOUN
fnp-3806	1207	34	,	,	PUNCT
fnp-3806	1207	35	iron	iron	NOUN
fnp-3806	1207	36	homeostasis	homeostasis	NOUN
fnp-3806	1207	37	,	,	PUNCT
fnp-3806	1207	38	and	and	CCONJ
fnp-3806	1207	39	membrane	membrane	NOUN
fnp-3806	1207	40	transport	transport	NOUN
fnp-3806	1207	41	(	(	PUNCT
fnp-3806	1207	42	1515	1515	NUM
fnp-3806	1207	43	)	)	PUNCT
fnp-3806	1207	44	.	.	PUNCT
fnp-3806	1208	1	recent	recent	ADJ
fnp-3806	1208	2	studies	study	NOUN
fnp-3806	1208	3	performed	perform	VERB
fnp-3806	1208	4	in	in	ADP
fnp-3806	1208	5	the	the	DET
fnp-3806	1208	6	entorhinal	entorhinal	ADJ
fnp-3806	1208	7	cortex	cortex	NOUN
fnp-3806	1208	8	and	and	CCONJ
fnp-3806	1208	9	frontal	frontal	ADJ
fnp-3806	1208	10	cortex	cortex	NOUN
fnp-3806	1208	11	in	in	ADP
fnp-3806	1208	12	human	human	ADJ
fnp-3806	1208	13	brain	brain	NOUN
fnp-3806	1208	14	aging	aging	NOUN
fnp-3806	1208	15	and	and	CCONJ
fnp-3806	1208	16	sad	sad	ADJ
fnp-3806	1208	17	at	at	ADP
fnp-3806	1208	18	different	different	ADJ
fnp-3806	1208	19	nft	nft	PROPN
fnp-3806	1208	20	stages	stage	NOUN
fnp-3806	1208	21	identified	identify	VERB
fnp-3806	1208	22	sixty	sixty	NUM
fnp-3806	1208	23	-	-	PUNCT
fnp-3806	1208	24	five	five	NUM
fnp-3806	1208	25	dysregulated	dysregulated	ADJ
fnp-3806	1208	26	phosphoproteins	phosphoprotein	NOUN
fnp-3806	1208	27	in	in	ADP
fnp-3806	1208	28	the	the	DET
fnp-3806	1208	29	entorhinal	entorhinal	ADJ
fnp-3806	1208	30	cortex	cortex	NOUN
fnp-3806	1208	31	,	,	PUNCT
fnp-3806	1208	32	and	and	CCONJ
fnp-3806	1208	33	eighty	eighty	NUM
fnp-3806	1208	34	-	-	PUNCT
fnp-3806	1208	35	one	one	NUM
fnp-3806	1208	36	phosphoproteins	phosphoprotein	NOUN
fnp-3806	1208	37	in	in	ADP
fnp-3806	1208	38	the	the	DET
fnp-3806	1208	39	frontal	frontal	ADJ
fnp-3806	1208	40	cortex	cortex	NOUN
fnp-3806	1208	41	at	at	ADP
fnp-3806	1208	42	nft	nft	PROPN
fnp-3806	1208	43	stages	stage	NOUN
fnp-3806	1208	44	i	i	PROPN
fnp-3806	1208	45	-	-	PUNCT
fnp-3806	1208	46	ii	ii	PROPN
fnp-3806	1208	47	when	when	SCONJ
fnp-3806	1208	48	compared	compare	VERB
fnp-3806	1208	49	with	with	ADP
fnp-3806	1208	50	ma	ma	PROPN
fnp-3806	1208	51	individuals	individual	NOUN
fnp-3806	1208	52	without	without	ADP
fnp-3806	1208	53	nft	nft	PROPN
fnp-3806	1208	54	pathology	pathology	PROPN
fnp-3806	1208	55	.	.	PUNCT
fnp-3806	1209	1	dysregulated	dysregulate	VERB
fnp-3806	1209	2	protein	protein	NOUN
fnp-3806	1209	3	phosphorylation	phosphorylation	NOUN
fnp-3806	1209	4	of	of	ADP
fnp-3806	1209	5	selected	select	VERB
fnp-3806	1209	6	proteins	protein	NOUN
fnp-3806	1209	7	occurs	occur	VERB
fnp-3806	1209	8	in	in	ADP
fnp-3806	1209	9	parallel	parallel	NOUN
fnp-3806	1209	10	with	with	ADP
fnp-3806	1209	11	the	the	DET
fnp-3806	1209	12	appearance	appearance	NOUN
fnp-3806	1209	13	of	of	ADP
fnp-3806	1209	14	nfts	nft	NOUN
fnp-3806	1209	15	in	in	ADP
fnp-3806	1209	16	the	the	DET
fnp-3806	1209	17	entorhinal	entorhinal	ADJ
fnp-3806	1209	18	cortex	cortex	NOUN
fnp-3806	1209	19	but	but	CCONJ
fnp-3806	1209	20	precedes	precede	VERB
fnp-3806	1209	21	the	the	DET
fnp-3806	1209	22	appearance	appearance	NOUN
fnp-3806	1209	23	of	of	ADP
fnp-3806	1209	24	nfts	nft	NOUN
fnp-3806	1209	25	and	and	CCONJ
fnp-3806	1209	26	sps	sps	NOUN
fnp-3806	1209	27	in	in	ADP
fnp-3806	1209	28	the	the	DET
fnp-3806	1209	29	frontal	frontal	ADJ
fnp-3806	1209	30	cortex	cortex	NOUN
fnp-3806	1209	31	.	.	PUNCT
fnp-3806	1210	1	the	the	DET
fnp-3806	1210	2	number	number	NOUN
fnp-3806	1210	3	of	of	ADP
fnp-3806	1210	4	dysregulated	dysregulated	ADJ
fnp-3806	1210	5	phosphoproteins	phosphoprotein	NOUN
fnp-3806	1210	6	increases	increase	NOUN
fnp-3806	1210	7	in	in	ADP
fnp-3806	1210	8	both	both	DET
fnp-3806	1210	9	regions	region	NOUN
fnp-3806	1210	10	with	with	ADP
fnp-3806	1210	11	nft	nft	PROPN
fnp-3806	1210	12	stage	stage	NOUN
fnp-3806	1210	13	,	,	PUNCT
fnp-3806	1210	14	most	most	ADJ
fnp-3806	1210	15	of	of	ADP
fnp-3806	1210	16	them	they	PRON
fnp-3806	1210	17	added	add	VERB
fnp-3806	1210	18	to	to	ADP
fnp-3806	1210	19	those	those	PRON
fnp-3806	1210	20	already	already	ADV
fnp-3806	1210	21	dysregulated	dysregulate	VERB
fnp-3806	1210	22	at	at	ADP
fnp-3806	1210	23	stages	stage	NOUN
fnp-3806	1210	24	i	i	PROPN
fnp-3806	1210	25	-	-	PUNCT
fnp-3806	1210	26	ii	ii	PROPN
fnp-3806	1210	27	.	.	PUNCT
fnp-3806	1211	1	considering	consider	VERB
fnp-3806	1211	2	the	the	DET
fnp-3806	1211	3	total	total	ADJ
fnp-3806	1211	4	number	number	NOUN
fnp-3806	1211	5	of	of	ADP
fnp-3806	1211	6	identified	identify	VERB
fnp-3806	1211	7	dysregulated	dysregulated	ADJ
fnp-3806	1211	8	phosphoproteins	phosphoprotein	NOUN
fnp-3806	1211	9	,	,	PUNCT
fnp-3806	1211	10	the	the	DET
fnp-3806	1211	11	most	most	ADV
fnp-3806	1211	12	active	active	ADJ
fnp-3806	1211	13	period	period	NOUN
fnp-3806	1211	14	corresponds	correspond	VERB
fnp-3806	1211	15	to	to	ADP
fnp-3806	1211	16	nft	nft	PROPN
fnp-3806	1211	17	stages	stages	PROPN
fnp-3806	1211	18	iii	iii	PROPN
fnp-3806	1211	19	-	-	PUNCT
fnp-3806	1211	20	iv	iv	NOUN
fnp-3806	1211	21	,	,	PUNCT
fnp-3806	1211	22	at	at	ADP
fnp-3806	1211	23	a	a	DET
fnp-3806	1211	24	time	time	NOUN
fnp-3806	1211	25	when	when	SCONJ
fnp-3806	1211	26	a	a	DET
fnp-3806	1211	27	subpopulation	subpopulation	NOUN
fnp-3806	1211	28	of	of	ADP
fnp-3806	1211	29	people	people	NOUN
fnp-3806	1211	30	might	might	AUX
fnp-3806	1211	31	be	be	AUX
fnp-3806	1211	32	clinically	clinically	ADV
fnp-3806	1211	33	categorized	categorize	VERB
fnp-3806	1211	34	as	as	ADP
fnp-3806	1211	35	suffering	suffer	VERB
fnp-3806	1211	36	from	from	ADP
fnp-3806	1211	37	mci	mci	PROPN
fnp-3806	1211	38	(	(	PUNCT
fnp-3806	1211	39	1417	1417	NUM
fnp-3806	1211	40	)	)	PUNCT
fnp-3806	1211	41	.	.	PUNCT
fnp-3806	1212	1	the	the	DET
fnp-3806	1212	2	main	main	ADJ
fnp-3806	1212	3	group	group	NOUN
fnp-3806	1212	4	of	of	ADP
fnp-3806	1212	5	dysregulated	dysregulated	ADJ
fnp-3806	1212	6	phosphoproteins	phosphoprotein	NOUN
fnp-3806	1212	7	at	at	ADP
fnp-3806	1212	8	nft	nft	PROPN
fnp-3806	1212	9	stages	stage	NOUN
fnp-3806	1212	10	i	i	PROPN
fnp-3806	1212	11	-	-	PUNCT
fnp-3806	1212	12	ii	ii	PROPN
fnp-3806	1212	13	are	be	AUX
fnp-3806	1212	14	membrane	membrane	ADJ
fnp-3806	1212	15	proteins	protein	NOUN
fnp-3806	1212	16	;	;	PUNCT
fnp-3806	1212	17	proteins	protein	NOUN
fnp-3806	1212	18	of	of	ADP
fnp-3806	1212	19	the	the	DET
fnp-3806	1212	20	cytoskeleton	cytoskeleton	NOUN
fnp-3806	1212	21	;	;	PUNCT
fnp-3806	1212	22	proteins	protein	NOUN
fnp-3806	1212	23	of	of	ADP
fnp-3806	1212	24	the	the	DET
fnp-3806	1212	25	synapses	synapsis	NOUN
fnp-3806	1212	26	and	and	CCONJ
fnp-3806	1212	27	dense	dense	ADJ
fnp-3806	1212	28	core	core	NOUN
fnp-3806	1212	29	vesicles	vesicle	NOUN
fnp-3806	1212	30	;	;	PUNCT
fnp-3806	1212	31	proteins	protein	NOUN
fnp-3806	1212	32	linked	link	VERB
fnp-3806	1212	33	to	to	ADP
fnp-3806	1212	34	membrane	membrane	NOUN
fnp-3806	1212	35	transport	transport	NOUN
fnp-3806	1212	36	and	and	CCONJ
fnp-3806	1212	37	ion	ion	NOUN
fnp-3806	1212	38	channels	channel	NOUN
fnp-3806	1212	39	;	;	PUNCT
fnp-3806	1212	40	kinases	kinase	NOUN
fnp-3806	1212	41	;	;	PUNCT
fnp-3806	1212	42	proteins	protein	NOUN
fnp-3806	1212	43	linked	link	VERB
fnp-3806	1212	44	to	to	ADP
fnp-3806	1212	45	dna	dna	PROPN
fnp-3806	1212	46	and	and	CCONJ
fnp-3806	1212	47	protein	protein	NOUN
fnp-3806	1212	48	deacetylation	deacetylation	NOUN
fnp-3806	1212	49	;	;	PUNCT
fnp-3806	1212	50	proteins	protein	NOUN
fnp-3806	1212	51	linked	link	VERB
fnp-3806	1212	52	to	to	ADP
fnp-3806	1212	53	gene	gene	NOUN
fnp-3806	1212	54	transcription	transcription	NOUN
fnp-3806	1212	55	and	and	CCONJ
fnp-3806	1212	56	protein	protein	NOUN
fnp-3806	1212	57	synthesis	synthesis	NOUN
fnp-3806	1212	58	,	,	PUNCT
fnp-3806	1212	59	and	and	CCONJ
fnp-3806	1212	60	proteins	protein	NOUN
fnp-3806	1212	61	involved	involve	VERB
fnp-3806	1212	62	in	in	ADP
fnp-3806	1212	63	energy	energy	NOUN
fnp-3806	1212	64	metabolism	metabolism	NOUN
fnp-3806	1212	65	(	(	PUNCT
fnp-3806	1212	66	1417	1417	NUM
fnp-3806	1212	67	)	)	PUNCT
fnp-3806	1212	68	.	.	PUNCT
fnp-3806	1213	1	altered	altered	ADJ
fnp-3806	1213	2	phosphorylation	phosphorylation	NOUN
fnp-3806	1213	3	of	of	ADP
fnp-3806	1213	4	selected	select	VERB
fnp-3806	1213	5	proteins	protein	NOUN
fnp-3806	1213	6	,	,	PUNCT
fnp-3806	1213	7	accomplished	accomplish	VERB
fnp-3806	1213	8	by	by	ADP
fnp-3806	1213	9	activation	activation	NOUN
fnp-3806	1213	10	of	of	ADP
fnp-3806	1213	11	several	several	ADJ
fnp-3806	1213	12	kinases	kinase	NOUN
fnp-3806	1213	13	,	,	PUNCT
fnp-3806	1213	14	may	may	AUX
fnp-3806	1213	15	alter	alter	VERB
fnp-3806	1213	16	membrane	membrane	NOUN
fnp-3806	1213	17	and	and	CCONJ
fnp-3806	1213	18	cytoskeletal	cytoskeletal	ADJ
fnp-3806	1213	19	function	function	NOUN
fnp-3806	1213	20	,	,	PUNCT
fnp-3806	1213	21	among	among	ADP
fnp-3806	1213	22	these	these	DET
fnp-3806	1213	23	synaptic	synaptic	ADJ
fnp-3806	1213	24	transmission	transmission	NOUN
fnp-3806	1213	25	and	and	CCONJ
fnp-3806	1213	26	membrane	membrane	NOUN
fnp-3806	1213	27	/	/	SYM
fnp-3806	1213	28	cytoskeleton	cytoskeleton	NOUN
fnp-3806	1213	29	signaling	signal	VERB
fnp-3806	1213	30	,	,	PUNCT
fnp-3806	1213	31	in	in	ADP
fnp-3806	1213	32	addition	addition	NOUN
fnp-3806	1213	33	to	to	ADP
fnp-3806	1213	34	energy	energy	NOUN
fnp-3806	1213	35	metabolism	metabolism	NOUN
fnp-3806	1213	36	,	,	PUNCT
fnp-3806	1213	37	protein	protein	NOUN
fnp-3806	1213	38	synthesis	synthesis	NOUN
fnp-3806	1213	39	,	,	PUNCT
fnp-3806	1213	40	and	and	CCONJ
fnp-3806	1213	41	dna	dna	NOUN
fnp-3806	1213	42	homeostasis	homeostasis	NOUN
fnp-3806	1213	43	(	(	PUNCT
fnp-3806	1213	44	1417	1417	NUM
fnp-3806	1213	45	)	)	PUNCT
fnp-3806	1213	46	.	.	PUNCT
fnp-3806	1214	1	dags	dag	NOUN
fnp-3806	1214	2	are	be	AUX
fnp-3806	1214	3	constituents	constituent	NOUN
fnp-3806	1214	4	of	of	ADP
fnp-3806	1214	5	cell	cell	NOUN
fnp-3806	1214	6	membranes	membrane	NOUN
fnp-3806	1214	7	that	that	PRON
fnp-3806	1214	8	participate	participate	VERB
fnp-3806	1214	9	in	in	ADP
fnp-3806	1214	10	intermediate	intermediate	ADJ
fnp-3806	1214	11	lipid	lipid	NOUN
fnp-3806	1214	12	metabolism	metabolism	NOUN
fnp-3806	1214	13	,	,	PUNCT
fnp-3806	1214	14	and	and	CCONJ
fnp-3806	1214	15	they	they	PRON
fnp-3806	1214	16	are	be	AUX
fnp-3806	1214	17	key	key	ADJ
fnp-3806	1214	18	components	component	NOUN
fnp-3806	1214	19	in	in	ADP
fnp-3806	1214	20	lipid	lipid	NOUN
fnp-3806	1214	21	-	-	PUNCT
fnp-3806	1214	22	mediated	mediate	VERB
fnp-3806	1214	23	signaling	signaling	NOUN
fnp-3806	1214	24	.	.	PUNCT
fnp-3806	1215	1	in	in	ADP
fnp-3806	1215	2	neurons	neuron	NOUN
fnp-3806	1215	3	,	,	PUNCT
fnp-3806	1215	4	dags	dag	NOUN
fnp-3806	1215	5	modulate	modulate	VERB
fnp-3806	1215	6	several	several	ADJ
fnp-3806	1215	7	signal	signal	NOUN
fnp-3806	1215	8	transduction	transduction	NOUN
fnp-3806	1215	9	proteins	protein	NOUN
fnp-3806	1215	10	linked	link	VERB
fnp-3806	1215	11	to	to	ADP
fnp-3806	1215	12	the	the	DET
fnp-3806	1215	13	activation	activation	NOUN
fnp-3806	1215	14	of	of	ADP
fnp-3806	1215	15	protein	protein	NOUN
fnp-3806	1215	16	kinases	kinase	NOUN
fnp-3806	1215	17	,	,	PUNCT
fnp-3806	1215	18	traffic	traffic	NOUN
fnp-3806	1215	19	and	and	CCONJ
fnp-3806	1215	20	fusion	fusion	NOUN
fnp-3806	1215	21	of	of	ADP
fnp-3806	1215	22	synaptic	synaptic	ADJ
fnp-3806	1215	23	vesicles	vesicle	NOUN
fnp-3806	1215	24	,	,	PUNCT
fnp-3806	1215	25	ion	ion	NOUN
fnp-3806	1215	26	channels	channel	NOUN
fnp-3806	1215	27	,	,	PUNCT
fnp-3806	1215	28	axonal	axonal	ADJ
fnp-3806	1215	29	guidance	guidance	NOUN
fnp-3806	1215	30	,	,	PUNCT
fnp-3806	1215	31	and	and	CCONJ
fnp-3806	1215	32	cytoskeletal	cytoskeletal	ADJ
fnp-3806	1215	33	homeostasis	homeostasis	NOUN
fnp-3806	1215	34	,	,	PUNCT
fnp-3806	1215	35	among	among	ADP
fnp-3806	1215	36	others	other	NOUN
fnp-3806	1215	37	(	(	PUNCT
fnp-3806	1215	38	1516	1516	NUM
fnp-3806	1215	39	-	-	SYM
fnp-3806	1215	40	1518	1518	NUM
fnp-3806	1215	41	)	)	PUNCT
fnp-3806	1215	42	.	.	PUNCT
fnp-3806	1216	1	tau	tau	PROPN
fnp-3806	1216	2	and	and	CCONJ
fnp-3806	1216	3	β	β	NOUN
fnp-3806	1216	4	-	-	ADJ
fnp-3806	1216	5	amyloid	amyloid	ADJ
fnp-3806	1216	6	phosphorylation	phosphorylation	NOUN
fnp-3806	1216	7	may	may	AUX
fnp-3806	1216	8	also	also	ADV
fnp-3806	1216	9	be	be	AUX
fnp-3806	1216	10	mediated	mediate	VERB
fnp-3806	1216	11	by	by	ADP
fnp-3806	1216	12	dags	dag	NOUN
fnp-3806	1216	13	and	and	CCONJ
fnp-3806	1216	14	pkc	pkc	PROPN
fnp-3806	1216	15	(	(	PUNCT
fnp-3806	1216	16	1519	1519	NUM
fnp-3806	1216	17	)	)	PUNCT
fnp-3806	1216	18	.	.	PUNCT
fnp-3806	1217	1	dag	dag	PROPN
fnp-3806	1217	2	levels	level	NOUN
fnp-3806	1217	3	are	be	AUX
fnp-3806	1217	4	increased	increase	VERB
fnp-3806	1217	5	in	in	ADP
fnp-3806	1217	6	the	the	DET
fnp-3806	1217	7	sad	sad	ADJ
fnp-3806	1217	8	frontal	frontal	ADJ
fnp-3806	1217	9	cortex	cortex	NOUN
fnp-3806	1217	10	(	(	PUNCT
fnp-3806	1217	11	1520	1520	NUM
fnp-3806	1217	12	,	,	PUNCT
fnp-3806	1217	13	1521	1521	NUM
fnp-3806	1217	14	)	)	PUNCT
fnp-3806	1217	15	.	.	PUNCT
fnp-3806	1218	1	further	further	ADJ
fnp-3806	1218	2	studies	study	NOUN
fnp-3806	1218	3	are	be	AUX
fnp-3806	1218	4	needed	need	VERB
fnp-3806	1218	5	to	to	PART
fnp-3806	1218	6	learn	learn	VERB
fnp-3806	1218	7	about	about	ADP
fnp-3806	1218	8	possible	possible	ADJ
fnp-3806	1218	9	links	link	NOUN
fnp-3806	1218	10	between	between	ADP
fnp-3806	1218	11	dags	dag	NOUN
fnp-3806	1218	12	and	and	CCONJ
fnp-3806	1218	13	abnormal	abnormal	ADJ
fnp-3806	1218	14	phosphorylation	phosphorylation	NOUN
fnp-3806	1218	15	of	of	ADP
fnp-3806	1218	16	cell	cell	NOUN
fnp-3806	1218	17	membrane	membrane	NOUN
fnp-3806	1218	18	proteins	protein	NOUN
fnp-3806	1218	19	.	.	PUNCT
fnp-3806	1219	1	23	23	NUM
fnp-3806	1219	2	.	.	X
fnp-3806	1220	1	concluding	conclude	VERB
fnp-3806	1220	2	comments	comment	NOUN
fnp-3806	1220	3	linear	linear	PROPN
fnp-3806	1220	4	logic	logic	NOUN
fnp-3806	1220	5	based	base	VERB
fnp-3806	1220	6	on	on	ADP
fnp-3806	1220	7	the	the	DET
fnp-3806	1220	8	assumption	assumption	NOUN
fnp-3806	1220	9	that	that	SCONJ
fnp-3806	1220	10	a	a	DET
fnp-3806	1220	11	cause	cause	NOUN
fnp-3806	1220	12	results	result	NOUN
fnp-3806	1220	13	in	in	ADP
fnp-3806	1220	14	one	one	NUM
fnp-3806	1220	15	or	or	CCONJ
fnp-3806	1220	16	several	several	ADJ
fnp-3806	1220	17	effects	effect	NOUN
fnp-3806	1220	18	does	do	AUX
fnp-3806	1220	19	not	not	PART
fnp-3806	1220	20	explain	explain	VERB
fnp-3806	1220	21	complex	complex	ADJ
fnp-3806	1220	22	biological	biological	ADJ
fnp-3806	1220	23	phenomena	phenomenon	NOUN
fnp-3806	1220	24	such	such	ADJ
fnp-3806	1220	25	as	as	ADP
fnp-3806	1220	26	brain	brain	NOUN
fnp-3806	1220	27	aging	aging	NOUN
fnp-3806	1220	28	and	and	CCONJ
fnp-3806	1220	29	sad	sad	ADJ
fnp-3806	1220	30	;	;	PUNCT
fnp-3806	1220	31	there	there	PRON
fnp-3806	1220	32	is	be	VERB
fnp-3806	1220	33	no	no	DET
fnp-3806	1220	34	single	single	ADJ
fnp-3806	1220	35	cause	cause	NOUN
fnp-3806	1220	36	of	of	ADP
fnp-3806	1220	37	aging	aging	NOUN
fnp-3806	1220	38	and	and	CCONJ
fnp-3806	1220	39	sad	sad	ADJ
fnp-3806	1220	40	.	.	PUNCT
fnp-3806	1221	1	rather	rather	ADV
fnp-3806	1221	2	,	,	PUNCT
fnp-3806	1221	3	the	the	DET
fnp-3806	1221	4	biological	biological	ADJ
fnp-3806	1221	5	processes	process	NOUN
fnp-3806	1221	6	involved	involve	VERB
fnp-3806	1221	7	in	in	ADP
fnp-3806	1221	8	generation	generation	NOUN
fnp-3806	1221	9	,	,	PUNCT
fnp-3806	1221	10	development	development	NOUN
fnp-3806	1221	11	,	,	PUNCT
fnp-3806	1221	12	living	living	NOUN
fnp-3806	1221	13	,	,	PUNCT
fnp-3806	1221	14	decline	decline	NOUN
fnp-3806	1221	15	,	,	PUNCT
fnp-3806	1221	16	and	and	CCONJ
fnp-3806	1221	17	death	death	NOUN
fnp-3806	1221	18	are	be	AUX
fnp-3806	1221	19	complex	complex	ADJ
fnp-3806	1221	20	concatenations	concatenation	NOUN
fnp-3806	1221	21	of	of	ADP
fnp-3806	1221	22	complementary	complementary	ADJ
fnp-3806	1221	23	,	,	PUNCT
fnp-3806	1221	24	disruptive	disruptive	ADJ
fnp-3806	1221	25	,	,	PUNCT
fnp-3806	1221	26	and	and	CCONJ
fnp-3806	1221	27	adaptive	adaptive	ADJ
fnp-3806	1221	28	responses	response	NOUN
fnp-3806	1221	29	.	.	PUNCT
fnp-3806	1222	1	not	not	PART
fnp-3806	1222	2	surprisingly	surprisingly	ADV
fnp-3806	1222	3	,	,	PUNCT
fnp-3806	1222	4	the	the	DET
fnp-3806	1222	5	mutually	mutually	ADV
fnp-3806	1222	6	exclusive	exclusive	ADJ
fnp-3806	1222	7	hypotheses	hypothesis	NOUN
fnp-3806	1222	8	formulated	formulate	VERB
fnp-3806	1222	9	to	to	PART
fnp-3806	1222	10	explain	explain	VERB
fnp-3806	1222	11	sad	sad	ADJ
fnp-3806	1222	12	are	be	AUX
fnp-3806	1222	13	not	not	PART
fnp-3806	1222	14	satisfactory	satisfactory	ADJ
fnp-3806	1222	15	.	.	PUNCT
fnp-3806	1223	1	genetic	genetic	ADJ
fnp-3806	1223	2	studies	study	NOUN
fnp-3806	1223	3	in	in	ADP
fnp-3806	1223	4	sad	sad	ADJ
fnp-3806	1223	5	have	have	AUX
fnp-3806	1223	6	also	also	ADV
fnp-3806	1223	7	provided	provide	VERB
fnp-3806	1223	8	a	a	DET
fnp-3806	1223	9	wealth	wealth	NOUN
fnp-3806	1223	10	of	of	ADP
fnp-3806	1223	11	information	information	NOUN
fnp-3806	1223	12	identifying	identify	VERB
fnp-3806	1223	13	genetic	genetic	ADJ
fnp-3806	1223	14	risk	risk	NOUN
fnp-3806	1223	15	factors	factor	NOUN
fnp-3806	1223	16	which	which	PRON
fnp-3806	1223	17	principally	principally	ADV
fnp-3806	1223	18	cover	cover	VERB
fnp-3806	1223	19	cholesterol	cholesterol	NOUN
fnp-3806	1223	20	and	and	CCONJ
fnp-3806	1223	21	lipid	lipid	NOUN
fnp-3806	1223	22	metabolism	metabolism	NOUN
fnp-3806	1223	23	,	,	PUNCT
fnp-3806	1223	24	inflammation	inflammation	NOUN
fnp-3806	1223	25	,	,	PUNCT
fnp-3806	1223	26	and	and	CCONJ
fnp-3806	1223	27	cell	cell	NOUN
fnp-3806	1223	28	membranes	membrane	NOUN
fnp-3806	1223	29	and	and	CCONJ
fnp-3806	1223	30	synapses	synapsis	NOUN
fnp-3806	1223	31	(	(	PUNCT
fnp-3806	1223	32	1390	1390	NUM
fnp-3806	1223	33	)	)	PUNCT
fnp-3806	1223	34	.	.	PUNCT
fnp-3806	1224	1	a	a	DET
fnp-3806	1224	2	scheme	scheme	NOUN
fnp-3806	1224	3	of	of	ADP
fnp-3806	1224	4	the	the	DET
fnp-3806	1224	5	several	several	ADJ
fnp-3806	1224	6	factors	factor	NOUN
fnp-3806	1224	7	involved	involve	VERB
fnp-3806	1224	8	in	in	ADP
fnp-3806	1224	9	brain	brain	NOUN
fnp-3806	1224	10	aging	aging	NOUN
fnp-3806	1224	11	and	and	CCONJ
fnp-3806	1224	12	sad	sad	ADJ
fnp-3806	1224	13	is	be	AUX
fnp-3806	1224	14	presented	present	VERB
fnp-3806	1224	15	in	in	ADP
fnp-3806	1224	16	figure	figure	NOUN
fnp-3806	1224	17	9	9	NUM
fnp-3806	1224	18	.	.	PUNCT
fnp-3806	1225	1	in	in	ADP
fnp-3806	1225	2	addition	addition	NOUN
fnp-3806	1225	3	to	to	ADP
fnp-3806	1225	4	genetic	genetic	ADJ
fnp-3806	1225	5	factors	factor	NOUN
fnp-3806	1225	6	,	,	PUNCT
fnp-3806	1225	7	there	there	PRON
fnp-3806	1225	8	is	be	VERB
fnp-3806	1225	9	an	an	DET
fnp-3806	1225	10	interaction	interaction	NOUN
fnp-3806	1225	11	between	between	ADP
fnp-3806	1225	12	molecular	molecular	ADJ
fnp-3806	1225	13	alterations	alteration	NOUN
fnp-3806	1225	14	in	in	ADP
fnp-3806	1225	15	cellular	cellular	ADJ
fnp-3806	1225	16	structures	structure	NOUN
fnp-3806	1225	17	that	that	PRON
fnp-3806	1225	18	may	may	AUX
fnp-3806	1225	19	favor	favor	VERB
fnp-3806	1225	20	the	the	DET
fnp-3806	1225	21	production	production	NOUN
fnp-3806	1225	22	of	of	ADP
fnp-3806	1225	23	β	β	NOUN
fnp-3806	1225	24	-	-	NOUN
fnp-3806	1225	25	amyloid	amyloid	NOUN
fnp-3806	1225	26	and	and	CCONJ
fnp-3806	1225	27	abnormal	abnormal	ADJ
fnp-3806	1225	28	tau	tau	NOUN
fnp-3806	1225	29	.	.	PUNCT
fnp-3806	1226	1	conversely	conversely	ADV
fnp-3806	1226	2	,	,	PUNCT
fnp-3806	1226	3	the	the	DET
fnp-3806	1226	4	presence	presence	NOUN
fnp-3806	1226	5	of	of	ADP
fnp-3806	1226	6	β	β	NOUN
fnp-3806	1226	7	-	-	NOUN
fnp-3806	1226	8	amyloid	amyloid	NOUN
fnp-3806	1226	9	and	and	CCONJ
fnp-3806	1226	10	abnormal	abnormal	ADJ
fnp-3806	1226	11	tau	tau	PROPN
fnp-3806	1226	12	has	have	VERB
fnp-3806	1226	13	a	a	DET
fnp-3806	1226	14	negative	negative	ADJ
fnp-3806	1226	15	effect	effect	NOUN
fnp-3806	1226	16	on	on	ADP
fnp-3806	1226	17	the	the	DET
fnp-3806	1226	18	majority	majority	NOUN
fnp-3806	1226	19	of	of	ADP
fnp-3806	1226	20	cellular	cellular	ADJ
fnp-3806	1226	21	structures	structure	NOUN
fnp-3806	1226	22	,	,	PUNCT
fnp-3806	1226	23	contributing	contribute	VERB
fnp-3806	1226	24	to	to	ADP
fnp-3806	1226	25	a	a	DET
fnp-3806	1226	26	detrimental	detrimental	ADJ
fnp-3806	1226	27	loop	loop	NOUN
fnp-3806	1226	28	in	in	ADP
fnp-3806	1226	29	sad	sad	ADJ
fnp-3806	1226	30	pathogenesis	pathogenesis	NOUN
fnp-3806	1226	31	.	.	PUNCT
fnp-3806	1227	1	figure	figure	VERB
fnp-3806	1227	2	9	9	NUM
fnp-3806	1227	3	:	:	PUNCT
fnp-3806	1227	4	factors	factor	NOUN
fnp-3806	1227	5	involved	involve	VERB
fnp-3806	1227	6	in	in	ADP
fnp-3806	1227	7	brain	brain	NOUN
fnp-3806	1227	8	aging	aging	NOUN
fnp-3806	1227	9	and	and	CCONJ
fnp-3806	1227	10	sad	sad	ADJ
fnp-3806	1227	11	.	.	PUNCT
fnp-3806	1228	1	in	in	ADP
fnp-3806	1228	2	addition	addition	NOUN
fnp-3806	1228	3	to	to	ADP
fnp-3806	1228	4	genetic	genetic	ADJ
fnp-3806	1228	5	factors	factor	NOUN
fnp-3806	1228	6	,	,	PUNCT
fnp-3806	1228	7	molecular	molecular	ADJ
fnp-3806	1228	8	alterations	alteration	NOUN
fnp-3806	1228	9	in	in	ADP
fnp-3806	1228	10	cellular	cellular	ADJ
fnp-3806	1228	11	structures	structure	NOUN
fnp-3806	1228	12	may	may	AUX
fnp-3806	1228	13	induce	induce	VERB
fnp-3806	1228	14	the	the	DET
fnp-3806	1228	15	production	production	NOUN
fnp-3806	1228	16	of	of	ADP
fnp-3806	1228	17	β	β	NOUN
fnp-3806	1228	18	-	-	NOUN
fnp-3806	1228	19	amyloid	amyloid	NOUN
fnp-3806	1228	20	and	and	CCONJ
fnp-3806	1228	21	abnormal	abnormal	ADJ
fnp-3806	1228	22	tau	tau	NOUN
fnp-3806	1228	23	.	.	PUNCT
fnp-3806	1229	1	conversely	conversely	ADV
fnp-3806	1229	2	,	,	PUNCT
fnp-3806	1229	3	the	the	DET
fnp-3806	1229	4	presence	presence	NOUN
fnp-3806	1229	5	of	of	ADP
fnp-3806	1229	6	β	β	NOUN
fnp-3806	1229	7	-	-	NOUN
fnp-3806	1229	8	amyloid	amyloid	NOUN
fnp-3806	1229	9	and	and	CCONJ
fnp-3806	1229	10	abnormal	abnormal	ADJ
fnp-3806	1229	11	tau	tau	PROPN
fnp-3806	1229	12	has	have	VERB
fnp-3806	1229	13	a	a	DET
fnp-3806	1229	14	negative	negative	ADJ
fnp-3806	1229	15	effect	effect	NOUN
fnp-3806	1229	16	on	on	ADP
fnp-3806	1229	17	the	the	DET
fnp-3806	1229	18	majority	majority	NOUN
fnp-3806	1229	19	of	of	ADP
fnp-3806	1229	20	cellular	cellular	ADJ
fnp-3806	1229	21	structures	structure	NOUN
fnp-3806	1229	22	,	,	PUNCT
fnp-3806	1229	23	contributing	contribute	VERB
fnp-3806	1229	24	to	to	ADP
fnp-3806	1229	25	a	a	DET
fnp-3806	1229	26	harmful	harmful	ADJ
fnp-3806	1229	27	loop	loop	NOUN
fnp-3806	1229	28	in	in	ADP
fnp-3806	1229	29	sad	sad	ADJ
fnp-3806	1229	30	pathogenesis	pathogenesis	NOUN
fnp-3806	1229	31	.	.	PUNCT
fnp-3806	1230	1	molecular	molecular	ADJ
fnp-3806	1230	2	alterations	alteration	NOUN
fnp-3806	1230	3	are	be	AUX
fnp-3806	1230	4	similar	similar	ADJ
fnp-3806	1230	5	and	and	CCONJ
fnp-3806	1230	6	cumulative	cumulative	ADJ
fnp-3806	1230	7	in	in	ADP
fnp-3806	1230	8	brain	brain	NOUN
fnp-3806	1230	9	aging	aging	NOUN
fnp-3806	1230	10	and	and	CCONJ
fnp-3806	1230	11	sad	sad	ADJ
fnp-3806	1230	12	.	.	PUNCT
fnp-3806	1231	1	therefore	therefore	ADV
fnp-3806	1231	2	,	,	PUNCT
fnp-3806	1231	3	a	a	DET
fnp-3806	1231	4	continuum	continuum	NOUN
fnp-3806	1231	5	of	of	ADP
fnp-3806	1231	6	brain	brain	NOUN
fnp-3806	1231	7	aging	aging	NOUN
fnp-3806	1231	8	and	and	CCONJ
fnp-3806	1231	9	sad	sad	ADJ
fnp-3806	1231	10	primarily	primarily	ADV
fnp-3806	1231	11	based	base	VERB
fnp-3806	1231	12	on	on	ADP
fnp-3806	1231	13	an	an	DET
fnp-3806	1231	14	archetypal	archetypal	ADJ
fnp-3806	1231	15	distribution	distribution	NOUN
fnp-3806	1231	16	of	of	ADP
fnp-3806	1231	17	nfts	nft	NOUN
fnp-3806	1231	18	usually	usually	ADV
fnp-3806	1231	19	followed	follow	VERB
fnp-3806	1231	20	by	by	ADP
fnp-3806	1231	21	the	the	DET
fnp-3806	1231	22	deposition	deposition	NOUN
fnp-3806	1231	23	of	of	ADP
fnp-3806	1231	24	β	β	NOUN
fnp-3806	1231	25	-	-	NOUN
fnp-3806	1231	26	amyloid	amyloid	ADJ
fnp-3806	1231	27	plaques	plaque	NOUN
fnp-3806	1231	28	is	be	AUX
fnp-3806	1231	29	a	a	DET
fnp-3806	1231	30	factual	factual	ADJ
fnp-3806	1231	31	possibility	possibility	NOUN
fnp-3806	1231	32	.	.	PUNCT
fnp-3806	1232	1	the	the	DET
fnp-3806	1232	2	pathogenesis	pathogenesis	NOUN
fnp-3806	1232	3	and	and	CCONJ
fnp-3806	1232	4	evolution	evolution	NOUN
fnp-3806	1232	5	of	of	ADP
fnp-3806	1232	6	arteriosclerosis	arteriosclerosis	NOUN
fnp-3806	1232	7	is	be	AUX
fnp-3806	1232	8	another	another	DET
fnp-3806	1232	9	example	example	NOUN
fnp-3806	1232	10	of	of	ADP
fnp-3806	1232	11	cumulative	cumulative	ADJ
fnp-3806	1232	12	age	age	NOUN
fnp-3806	1232	13	-	-	PUNCT
fnp-3806	1232	14	related	relate	VERB
fnp-3806	1232	15	degenerative	degenerative	ADJ
fnp-3806	1232	16	changes	change	NOUN
fnp-3806	1232	17	in	in	ADP
fnp-3806	1232	18	blood	blood	NOUN
fnp-3806	1232	19	vessels	vessel	NOUN
fnp-3806	1232	20	.	.	PUNCT
fnp-3806	1233	1	almost	almost	ADV
fnp-3806	1233	2	all	all	DET
fnp-3806	1233	3	people	people	NOUN
fnp-3806	1233	4	are	be	AUX
fnp-3806	1233	5	affected	affect	VERB
fnp-3806	1233	6	to	to	ADP
fnp-3806	1233	7	some	some	DET
fnp-3806	1233	8	degree	degree	NOUN
fnp-3806	1233	9	by	by	ADP
fnp-3806	1233	10	the	the	DET
fnp-3806	1233	11	age	age	NOUN
fnp-3806	1233	12	of	of	ADP
fnp-3806	1233	13	65	65	NUM
fnp-3806	1233	14	.	.	PUNCT
fnp-3806	1234	1	however	however	ADV
fnp-3806	1234	2	,	,	PUNCT
fnp-3806	1234	3	the	the	DET
fnp-3806	1234	4	first	first	ADJ
fnp-3806	1234	5	lesions	lesion	NOUN
fnp-3806	1234	6	in	in	ADP
fnp-3806	1234	7	atherosclerosis	atherosclerosis	NOUN
fnp-3806	1234	8	,	,	PUNCT
fnp-3806	1234	9	characterized	characterize	VERB
fnp-3806	1234	10	by	by	ADP
fnp-3806	1234	11	macrophage	macrophage	ADJ
fnp-3806	1234	12	infiltration	infiltration	NOUN
fnp-3806	1234	13	and	and	CCONJ
fnp-3806	1234	14	intracellular	intracellular	ADJ
fnp-3806	1234	15	lipid	lipid	NOUN
fnp-3806	1234	16	accumulation	accumulation	NOUN
fnp-3806	1234	17	in	in	ADP
fnp-3806	1234	18	the	the	DET
fnp-3806	1234	19	blood	blood	NOUN
fnp-3806	1234	20	vessel	vessel	NOUN
fnp-3806	1234	21	wall	wall	NOUN
fnp-3806	1234	22	,	,	PUNCT
fnp-3806	1234	23	may	may	AUX
fnp-3806	1234	24	occur	occur	VERB
fnp-3806	1234	25	in	in	ADP
fnp-3806	1234	26	the	the	DET
fnp-3806	1234	27	first	first	ADJ
fnp-3806	1234	28	or	or	CCONJ
fnp-3806	1234	29	second	second	ADJ
fnp-3806	1234	30	decade	decade	NOUN
fnp-3806	1234	31	;	;	PUNCT
fnp-3806	1234	32	inflammation	inflammation	NOUN
fnp-3806	1234	33	,	,	PUNCT
fnp-3806	1234	34	endothelial	endothelial	ADJ
fnp-3806	1234	35	and	and	CCONJ
fnp-3806	1234	36	perycite	perycite	ADJ
fnp-3806	1234	37	damage	damage	NOUN
fnp-3806	1234	38	,	,	PUNCT
fnp-3806	1234	39	altered	alter	VERB
fnp-3806	1234	40	metabolism	metabolism	NOUN
fnp-3806	1234	41	of	of	ADP
fnp-3806	1234	42	muscle	muscle	NOUN
fnp-3806	1234	43	fibers	fiber	NOUN
fnp-3806	1234	44	,	,	PUNCT
fnp-3806	1234	45	extracellular	extracellular	ADJ
fnp-3806	1234	46	lipid	lipid	NOUN
fnp-3806	1234	47	cores	core	NOUN
fnp-3806	1234	48	and	and	CCONJ
fnp-3806	1234	49	atheromatous	atheromatous	ADJ
fnp-3806	1234	50	plaques	plaque	NOUN
fnp-3806	1234	51	develop	develop	VERB
fnp-3806	1234	52	later	later	ADV
fnp-3806	1234	53	.	.	PUNCT
fnp-3806	1235	1	clinical	clinical	ADJ
fnp-3806	1235	2	manifestations	manifestation	NOUN
fnp-3806	1235	3	may	may	AUX
fnp-3806	1235	4	appear	appear	VERB
fnp-3806	1235	5	at	at	ADP
fnp-3806	1235	6	advanced	advanced	ADJ
fnp-3806	1235	7	stages	stage	NOUN
fnp-3806	1235	8	of	of	ADP
fnp-3806	1235	9	fibroatheroma	fibroatheroma	ADJ
fnp-3806	1235	10	,	,	PUNCT
fnp-3806	1235	11	as	as	ADV
fnp-3806	1235	12	well	well	ADV
fnp-3806	1235	13	as	as	ADP
fnp-3806	1235	14	complicated	complicated	ADJ
fnp-3806	1235	15	lesions	lesion	NOUN
fnp-3806	1235	16	in	in	ADP
fnp-3806	1235	17	ma	ma	PROPN
fnp-3806	1235	18	individuals	individual	NOUN
fnp-3806	1235	19	.	.	PUNCT
fnp-3806	1236	1	thus	thus	ADV
fnp-3806	1236	2	,	,	PUNCT
fnp-3806	1236	3	the	the	DET
fnp-3806	1236	4	atheromatous	atheromatous	ADJ
fnp-3806	1236	5	plaque	plaque	NOUN
fnp-3806	1236	6	,	,	PUNCT
fnp-3806	1236	7	the	the	DET
fnp-3806	1236	8	characteristic	characteristic	ADJ
fnp-3806	1236	9	lesion	lesion	NOUN
fnp-3806	1236	10	of	of	ADP
fnp-3806	1236	11	atherosclerosis	atherosclerosis	NOUN
fnp-3806	1236	12	,	,	PUNCT
fnp-3806	1236	13	is	be	AUX
fnp-3806	1236	14	not	not	PART
fnp-3806	1236	15	the	the	DET
fnp-3806	1236	16	first	first	ADJ
fnp-3806	1236	17	requirement	requirement	NOUN
fnp-3806	1236	18	to	to	PART
fnp-3806	1236	19	identify	identify	VERB
fnp-3806	1236	20	atherosclerosis	atherosclerosis	NOUN
fnp-3806	1236	21	as	as	ADP
fnp-3806	1236	22	a	a	DET
fnp-3806	1236	23	biological	biological	ADJ
fnp-3806	1236	24	process	process	NOUN
fnp-3806	1236	25	which	which	PRON
fnp-3806	1236	26	is	be	AUX
fnp-3806	1236	27	expressed	express	VERB
fnp-3806	1236	28	by	by	ADP
fnp-3806	1236	29	cumulative	cumulative	ADJ
fnp-3806	1236	30	stages	stage	NOUN
fnp-3806	1236	31	of	of	ADP
fnp-3806	1236	32	blood	blood	NOUN
fnp-3806	1236	33	vessel	vessel	NOUN
fnp-3806	1236	34	damage	damage	NOUN
fnp-3806	1236	35	leading	lead	VERB
fnp-3806	1236	36	or	or	CCONJ
fnp-3806	1236	37	not	not	PART
fnp-3806	1236	38	to	to	ADP
fnp-3806	1236	39	clinical	clinical	ADJ
fnp-3806	1236	40	manifestations	manifestation	NOUN
fnp-3806	1236	41	of	of	ADP
fnp-3806	1236	42	variable	variable	ADJ
fnp-3806	1236	43	severity	severity	NOUN
fnp-3806	1236	44	.	.	PUNCT
fnp-3806	1237	1	searching	search	VERB
fnp-3806	1237	2	possible	possible	ADJ
fnp-3806	1237	3	therapies	therapy	NOUN
fnp-3806	1237	4	for	for	ADP
fnp-3806	1237	5	sad	sad	ADJ
fnp-3806	1237	6	has	have	AUX
fnp-3806	1237	7	been	be	AUX
fnp-3806	1237	8	constant	constant	ADJ
fnp-3806	1237	9	over	over	ADP
fnp-3806	1237	10	the	the	DET
fnp-3806	1237	11	years	year	NOUN
fnp-3806	1237	12	.	.	PUNCT
fnp-3806	1238	1	cholinesterase	cholinesterase	NOUN
fnp-3806	1238	2	inhibitors	inhibitor	NOUN
fnp-3806	1238	3	,	,	PUNCT
fnp-3806	1238	4	nmda	nmda	ADJ
fnp-3806	1238	5	receptor	receptor	NOUN
fnp-3806	1238	6	antagonists	antagonist	NOUN
fnp-3806	1238	7	,	,	PUNCT
fnp-3806	1238	8	membrane	membrane	NOUN
fnp-3806	1238	9	protectors	protector	NOUN
fnp-3806	1238	10	,	,	PUNCT
fnp-3806	1238	11	anti	anti	NOUN
fnp-3806	1238	12	-	-	NOUN
fnp-3806	1238	13	oxidants	oxidant	NOUN
fnp-3806	1238	14	,	,	PUNCT
fnp-3806	1238	15	and	and	CCONJ
fnp-3806	1238	16	anti	anti	ADJ
fnp-3806	1238	17	-	-	ADJ
fnp-3806	1238	18	inflammatory	inflammatory	ADJ
fnp-3806	1238	19	agents	agent	NOUN
fnp-3806	1238	20	,	,	PUNCT
fnp-3806	1238	21	all	all	PRON
fnp-3806	1238	22	assayed	assayed	ADJ
fnp-3806	1238	23	at	at	ADP
fnp-3806	1238	24	middle	middle	ADJ
fnp-3806	1238	25	and	and	CCONJ
fnp-3806	1238	26	advanced	advanced	ADJ
fnp-3806	1238	27	clinical	clinical	ADJ
fnp-3806	1238	28	stages	stage	NOUN
fnp-3806	1238	29	of	of	ADP
fnp-3806	1238	30	sad	sad	ADJ
fnp-3806	1238	31	,	,	PUNCT
fnp-3806	1238	32	have	have	AUX
fnp-3806	1238	33	proven	prove	VERB
fnp-3806	1238	34	poorly	poorly	ADV
fnp-3806	1238	35	effective	effective	ADJ
fnp-3806	1238	36	.	.	PUNCT
fnp-3806	1239	1	other	other	ADJ
fnp-3806	1239	2	treatments	treatment	NOUN
fnp-3806	1239	3	are	be	AUX
fnp-3806	1239	4	directed	direct	VERB
fnp-3806	1239	5	to	to	ADP
fnp-3806	1239	6	reducing	reduce	VERB
fnp-3806	1239	7	β	β	NOUN
fnp-3806	1239	8	-	-	NOUN
fnp-3806	1239	9	amyloid	amyloid	NOUN
fnp-3806	1239	10	or	or	CCONJ
fnp-3806	1239	11	tau	tau	PROPN
fnp-3806	1239	12	accumulation	accumulation	NOUN
fnp-3806	1239	13	.	.	PUNCT
fnp-3806	1240	1	several	several	ADJ
fnp-3806	1240	2	aβ	aβ	ADJ
fnp-3806	1240	3	-	-	PUNCT
fnp-3806	1240	4	protein	protein	NOUN
fnp-3806	1240	5	-	-	PUNCT
fnp-3806	1240	6	targeted	target	VERB
fnp-3806	1240	7	drugs	drug	NOUN
fnp-3806	1240	8	,	,	PUNCT
fnp-3806	1240	9	including	include	VERB
fnp-3806	1240	10	β	β	NOUN
fnp-3806	1240	11	-	-	ADJ
fnp-3806	1240	12	secretase	secretase	ADJ
fnp-3806	1240	13	inhibitors	inhibitor	NOUN
fnp-3806	1240	14	,	,	PUNCT
fnp-3806	1240	15	γ	γ	NOUN
fnp-3806	1240	16	-	-	ADJ
fnp-3806	1240	17	secretase	secretase	ADJ
fnp-3806	1240	18	inhibitors	inhibitor	NOUN
fnp-3806	1240	19	and	and	CCONJ
fnp-3806	1240	20	modulators	modulator	NOUN
fnp-3806	1240	21	,	,	PUNCT
fnp-3806	1240	22	α	α	NOUN
fnp-3806	1240	23	-	-	PUNCT
fnp-3806	1240	24	secretase	secretase	NOUN
fnp-3806	1240	25	activators	activator	NOUN
fnp-3806	1240	26	,	,	PUNCT
fnp-3806	1240	27	direct	direct	ADJ
fnp-3806	1240	28	inhibitors	inhibitor	NOUN
fnp-3806	1240	29	of	of	ADP
fnp-3806	1240	30	aβ	aβ	DET
fnp-3806	1240	31	aggregation	aggregation	NOUN
fnp-3806	1240	32	,	,	PUNCT
fnp-3806	1240	33	and	and	CCONJ
fnp-3806	1240	34	immunotherapy	immunotherapy	NOUN
fnp-3806	1240	35	have	have	AUX
fnp-3806	1240	36	been	be	AUX
fnp-3806	1240	37	assayed	assayed	ADJ
fnp-3806	1240	38	or	or	CCONJ
fnp-3806	1240	39	are	be	AUX
fnp-3806	1240	40	under	under	ADP
fnp-3806	1240	41	different	different	ADJ
fnp-3806	1240	42	phases	phase	NOUN
fnp-3806	1240	43	of	of	ADP
fnp-3806	1240	44	clinical	clinical	ADJ
fnp-3806	1240	45	trial	trial	NOUN
fnp-3806	1240	46	(	(	PUNCT
fnp-3806	1240	47	1522	1522	NUM
fnp-3806	1240	48	)	)	PUNCT
fnp-3806	1240	49	.	.	PUNCT
fnp-3806	1241	1	β	β	X
fnp-3806	1241	2	-	-	PUNCT
fnp-3806	1241	3	amyloid	amyloid	NOUN
fnp-3806	1241	4	immunization	immunization	NOUN
fnp-3806	1241	5	in	in	ADP
fnp-3806	1241	6	humans	human	NOUN
fnp-3806	1241	7	has	have	AUX
fnp-3806	1241	8	been	be	AUX
fnp-3806	1241	9	successful	successful	ADJ
fnp-3806	1241	10	in	in	ADP
fnp-3806	1241	11	the	the	DET
fnp-3806	1241	12	sense	sense	NOUN
fnp-3806	1241	13	that	that	SCONJ
fnp-3806	1241	14	sps	sps	PROPN
fnp-3806	1241	15	are	be	AUX
fnp-3806	1241	16	largely	largely	ADV
fnp-3806	1241	17	reduced	reduce	VERB
fnp-3806	1241	18	in	in	ADP
fnp-3806	1241	19	the	the	DET
fnp-3806	1241	20	brain	brain	NOUN
fnp-3806	1241	21	of	of	ADP
fnp-3806	1241	22	treated	treat	VERB
fnp-3806	1241	23	patients	patient	NOUN
fnp-3806	1241	24	;	;	PUNCT
fnp-3806	1241	25	yet	yet	CCONJ
fnp-3806	1241	26	the	the	DET
fnp-3806	1241	27	abundance	abundance	NOUN
fnp-3806	1241	28	of	of	ADP
fnp-3806	1241	29	tau	tau	PROPN
fnp-3806	1241	30	deposits	deposit	NOUN
fnp-3806	1241	31	and	and	CCONJ
fnp-3806	1241	32	the	the	DET
fnp-3806	1241	33	progression	progression	NOUN
fnp-3806	1241	34	of	of	ADP
fnp-3806	1241	35	the	the	DET
fnp-3806	1241	36	disease	disease	NOUN
fnp-3806	1241	37	are	be	AUX
fnp-3806	1241	38	not	not	PART
fnp-3806	1241	39	substantially	substantially	ADV
fnp-3806	1241	40	modified	modify	VERB
fnp-3806	1241	41	by	by	ADP
fnp-3806	1241	42	β	β	NOUN
fnp-3806	1241	43	-	-	NOUN
fnp-3806	1241	44	amyloid	amyloid	ADJ
fnp-3806	1241	45	immunization	immunization	NOUN
fnp-3806	1241	46	(	(	PUNCT
fnp-3806	1241	47	719	719	NUM
fnp-3806	1241	48	,	,	PUNCT
fnp-3806	1241	49	1523	1523	NUM
fnp-3806	1241	50	,	,	PUNCT
fnp-3806	1241	51	1524	1524	NUM
fnp-3806	1241	52	)	)	PUNCT
fnp-3806	1241	53	.	.	PUNCT
fnp-3806	1242	1	the	the	DET
fnp-3806	1242	2	clinical	clinical	ADJ
fnp-3806	1242	3	improvement	improvement	NOUN
fnp-3806	1242	4	seen	see	VERB
fnp-3806	1242	5	with	with	ADP
fnp-3806	1242	6	β	β	NOUN
fnp-3806	1242	7	-	-	NOUN
fnp-3806	1242	8	amyloid	amyloid	ADJ
fnp-3806	1242	9	immunotherapy	immunotherapy	NOUN
fnp-3806	1242	10	has	have	AUX
fnp-3806	1242	11	been	be	AUX
fnp-3806	1242	12	null	null	ADJ
fnp-3806	1242	13	or	or	CCONJ
fnp-3806	1242	14	negligible	negligible	ADJ
fnp-3806	1242	15	,	,	PUNCT
fnp-3806	1242	16	or	or	CCONJ
fnp-3806	1242	17	at	at	ADP
fnp-3806	1242	18	best	good	ADJ
fnp-3806	1242	19	arguable	arguable	ADJ
fnp-3806	1242	20	(	(	PUNCT
fnp-3806	1242	21	1525	1525	NUM
fnp-3806	1242	22	-	-	SYM
fnp-3806	1242	23	1530	1530	NUM
fnp-3806	1242	24	)	)	PUNCT
fnp-3806	1242	25	.	.	PUNCT
fnp-3806	1243	1	treatment	treatment	NOUN
fnp-3806	1243	2	with	with	ADP
fnp-3806	1243	3	a	a	DET
fnp-3806	1243	4	bace1	bace1	NOUN
fnp-3806	1243	5	inhibitor	inhibitor	NOUN
fnp-3806	1243	6	has	have	AUX
fnp-3806	1243	7	yielded	yield	VERB
fnp-3806	1243	8	very	very	ADV
fnp-3806	1243	9	limited	limited	ADJ
fnp-3806	1243	10	neuropathological	neuropathological	ADJ
fnp-3806	1243	11	improvement	improvement	NOUN
fnp-3806	1243	12	(	(	PUNCT
fnp-3806	1243	13	1531	1531	NUM
fnp-3806	1243	14	)	)	PUNCT
fnp-3806	1243	15	.	.	PUNCT
fnp-3806	1244	1	trials	trial	NOUN
fnp-3806	1244	2	with	with	ADP
fnp-3806	1244	3	new	new	ADJ
fnp-3806	1244	4	generation	generation	NOUN
fnp-3806	1244	5	aβ	aβ	NOUN
fnp-3806	1244	6	immunotherapy	immunotherapy	NOUN
fnp-3806	1244	7	are	be	AUX
fnp-3806	1244	8	in	in	ADP
fnp-3806	1244	9	progress	progress	NOUN
fnp-3806	1244	10	.	.	PUNCT
fnp-3806	1245	1	following	follow	VERB
fnp-3806	1245	2	the	the	DET
fnp-3806	1245	3	same	same	ADJ
fnp-3806	1245	4	line	line	NOUN
fnp-3806	1245	5	of	of	ADP
fnp-3806	1245	6	thinking	thinking	NOUN
fnp-3806	1245	7	,	,	PUNCT
fnp-3806	1245	8	tau	tau	PROPN
fnp-3806	1245	9	immunization	immunization	NOUN
fnp-3806	1245	10	,	,	PUNCT
fnp-3806	1245	11	although	although	SCONJ
fnp-3806	1245	12	putatively	putatively	ADV
fnp-3806	1245	13	preventing	prevent	VERB
fnp-3806	1245	14	tau	tau	PROPN
fnp-3806	1245	15	accumulation	accumulation	NOUN
fnp-3806	1245	16	,	,	PUNCT
fnp-3806	1245	17	is	be	AUX
fnp-3806	1245	18	unlikely	unlikely	ADJ
fnp-3806	1245	19	to	to	PART
fnp-3806	1245	20	be	be	AUX
fnp-3806	1245	21	a	a	DET
fnp-3806	1245	22	unique	unique	ADJ
fnp-3806	1245	23	alternative	alternative	ADJ
fnp-3806	1245	24	treatment	treatment	NOUN
fnp-3806	1245	25	(	(	PUNCT
fnp-3806	1245	26	1532	1532	NUM
fnp-3806	1245	27	-	-	SYM
fnp-3806	1245	28	1534	1534	NUM
fnp-3806	1245	29	)	)	PUNCT
fnp-3806	1245	30	.	.	PUNCT
fnp-3806	1246	1	various	various	ADJ
fnp-3806	1246	2	tau	tau	PROPN
fnp-3806	1246	3	-	-	PUNCT
fnp-3806	1246	4	based	base	VERB
fnp-3806	1246	5	therapies	therapy	NOUN
fnp-3806	1246	6	have	have	AUX
fnp-3806	1246	7	been	be	AUX
fnp-3806	1246	8	developed	develop	VERB
fnp-3806	1246	9	or	or	CCONJ
fnp-3806	1246	10	are	be	AUX
fnp-3806	1246	11	under	under	ADP
fnp-3806	1246	12	development	development	NOUN
fnp-3806	1246	13	.	.	PUNCT
fnp-3806	1247	1	these	these	DET
fnp-3806	1247	2	therapies	therapy	NOUN
fnp-3806	1247	3	include	include	VERB
fnp-3806	1247	4	the	the	DET
fnp-3806	1247	5	use	use	NOUN
fnp-3806	1247	6	of	of	ADP
fnp-3806	1247	7	inhibitors	inhibitor	NOUN
fnp-3806	1247	8	of	of	ADP
fnp-3806	1247	9	tau	tau	PROPN
fnp-3806	1247	10	phosphorylation	phosphorylation	NOUN
fnp-3806	1247	11	,	,	PUNCT
fnp-3806	1247	12	glycosylation	glycosylation	NOUN
fnp-3806	1247	13	,	,	PUNCT
fnp-3806	1247	14	and	and	CCONJ
fnp-3806	1247	15	acetylation	acetylation	NOUN
fnp-3806	1247	16	;	;	PUNCT
fnp-3806	1247	17	microtubule	microtubule	NOUN
fnp-3806	1247	18	stabilizers	stabilizer	NOUN
fnp-3806	1247	19	;	;	PUNCT
fnp-3806	1247	20	inhibitors	inhibitor	NOUN
fnp-3806	1247	21	of	of	ADP
fnp-3806	1247	22	tau	tau	PROPN
fnp-3806	1247	23	aggregation	aggregation	NOUN
fnp-3806	1247	24	;	;	PUNCT
fnp-3806	1247	25	and	and	CCONJ
fnp-3806	1247	26	anti	anti	ADJ
fnp-3806	1247	27	-	-	ADJ
fnp-3806	1247	28	tau	tau	ADJ
fnp-3806	1247	29	immunotherapy	immunotherapy	NOUN
fnp-3806	1247	30	(	(	PUNCT
fnp-3806	1247	31	1535	1535	NUM
fnp-3806	1247	32	-	-	SYM
fnp-3806	1247	33	1538	1538	NUM
fnp-3806	1247	34	)	)	PUNCT
fnp-3806	1247	35	.	.	PUNCT
fnp-3806	1248	1	various	various	ADJ
fnp-3806	1248	2	tau	tau	PROPN
fnp-3806	1248	3	therapies	therapy	NOUN
fnp-3806	1248	4	based	base	VERB
fnp-3806	1248	5	on	on	ADP
fnp-3806	1248	6	active	active	ADJ
fnp-3806	1248	7	and	and	CCONJ
fnp-3806	1248	8	passive	passive	ADJ
fnp-3806	1248	9	immunization	immunization	NOUN
fnp-3806	1248	10	are	be	AUX
fnp-3806	1248	11	effective	effective	ADJ
fnp-3806	1248	12	in	in	ADP
fnp-3806	1248	13	murine	murine	ADJ
fnp-3806	1248	14	and	and	CCONJ
fnp-3806	1248	15	primate	primate	ADJ
fnp-3806	1248	16	models	model	NOUN
fnp-3806	1248	17	.	.	PUNCT
fnp-3806	1249	1	however	however	ADV
fnp-3806	1249	2	,	,	PUNCT
fnp-3806	1249	3	some	some	PRON
fnp-3806	1249	4	of	of	ADP
fnp-3806	1249	5	these	these	DET
fnp-3806	1249	6	attempts	attempt	NOUN
fnp-3806	1249	7	have	have	AUX
fnp-3806	1249	8	failed	fail	VERB
fnp-3806	1249	9	in	in	ADP
fnp-3806	1249	10	sad	sad	ADJ
fnp-3806	1249	11	(	(	PUNCT
fnp-3806	1249	12	1539	1539	NUM
fnp-3806	1249	13	)	)	PUNCT
fnp-3806	1249	14	.	.	PUNCT
fnp-3806	1250	1	although	although	SCONJ
fnp-3806	1250	2	encouraging	encouraging	ADJ
fnp-3806	1250	3	,	,	PUNCT
fnp-3806	1250	4	it	it	PRON
fnp-3806	1250	5	is	be	AUX
fnp-3806	1250	6	not	not	PART
fnp-3806	1250	7	clear	clear	ADJ
fnp-3806	1250	8	how	how	SCONJ
fnp-3806	1250	9	such	such	ADJ
fnp-3806	1250	10	treatments	treatment	NOUN
fnp-3806	1250	11	will	will	AUX
fnp-3806	1250	12	reduce	reduce	VERB
fnp-3806	1250	13	the	the	DET
fnp-3806	1250	14	different	different	ADJ
fnp-3806	1250	15	forms	form	NOUN
fnp-3806	1250	16	of	of	ADP
fnp-3806	1250	17	abnormal	abnormal	ADJ
fnp-3806	1250	18	tau	tau	NOUN
fnp-3806	1250	19	and	and	CCONJ
fnp-3806	1250	20	decrease	decrease	VERB
fnp-3806	1250	21	aβ	aβ	DET
fnp-3806	1250	22	burden	burden	NOUN
fnp-3806	1250	23	.	.	PUNCT
fnp-3806	1251	1	in	in	ADP
fnp-3806	1251	2	short	short	ADJ
fnp-3806	1251	3	,	,	PUNCT
fnp-3806	1251	4	there	there	PRON
fnp-3806	1251	5	is	be	VERB
fnp-3806	1251	6	no	no	DET
fnp-3806	1251	7	evidence	evidence	NOUN
fnp-3806	1251	8	that	that	SCONJ
fnp-3806	1251	9	merely	merely	ADV
fnp-3806	1251	10	lessening	lessen	VERB
fnp-3806	1251	11	the	the	DET
fnp-3806	1251	12	abnormal	abnormal	ADJ
fnp-3806	1251	13	levels	level	NOUN
fnp-3806	1251	14	and	and	CCONJ
fnp-3806	1251	15	deposits	deposit	NOUN
fnp-3806	1251	16	of	of	ADP
fnp-3806	1251	17	tau	tau	PROPN
fnp-3806	1251	18	or	or	CCONJ
fnp-3806	1251	19	β	β	NOUN
fnp-3806	1251	20	-	-	NOUN
fnp-3806	1251	21	amyloid	amyloid	NOUN
fnp-3806	1251	22	at	at	ADP
fnp-3806	1251	23	middle	middle	ADJ
fnp-3806	1251	24	and	and	CCONJ
fnp-3806	1251	25	advanced	advanced	ADJ
fnp-3806	1251	26	stages	stage	NOUN
fnp-3806	1251	27	of	of	ADP
fnp-3806	1251	28	the	the	DET
fnp-3806	1251	29	illness	illness	NOUN
fnp-3806	1251	30	will	will	AUX
fnp-3806	1251	31	cure	cure	VERB
fnp-3806	1251	32	sad	sad	ADJ
fnp-3806	1251	33	.	.	PUNCT
fnp-3806	1252	1	therefore	therefore	ADV
fnp-3806	1252	2	,	,	PUNCT
fnp-3806	1252	3	it	it	PRON
fnp-3806	1252	4	is	be	AUX
fnp-3806	1252	5	crucial	crucial	ADJ
fnp-3806	1252	6	to	to	PART
fnp-3806	1252	7	re	re	VERB
fnp-3806	1252	8	-	-	VERB
fnp-3806	1252	9	consider	consider	VERB
fnp-3806	1252	10	the	the	DET
fnp-3806	1252	11	optimal	optimal	ADJ
fnp-3806	1252	12	age	age	NOUN
fnp-3806	1252	13	to	to	PART
fnp-3806	1252	14	start	start	VERB
fnp-3806	1252	15	combined	combined	ADJ
fnp-3806	1252	16	anti	anti	ADJ
fnp-3806	1252	17	-	-	ADJ
fnp-3806	1252	18	tauand	tauand	ADJ
fnp-3806	1252	19	anti	anti	ADJ
fnp-3806	1252	20	-	-	ADJ
fnp-3806	1252	21	β	β	ADJ
fnp-3806	1252	22	-	-	ADJ
fnp-3806	1252	23	amyloid	amyloid	NOUN
fnp-3806	1252	24	-	-	PUNCT
fnp-3806	1252	25	based	base	VERB
fnp-3806	1252	26	treatments	treatment	NOUN
fnp-3806	1252	27	to	to	PART
fnp-3806	1252	28	combat	combat	VERB
fnp-3806	1252	29	two	two	NUM
fnp-3806	1252	30	main	main	ADJ
fnp-3806	1252	31	representative	representative	ADJ
fnp-3806	1252	32	components	component	NOUN
fnp-3806	1252	33	of	of	ADP
fnp-3806	1252	34	ad	ad	NOUN
fnp-3806	1252	35	.	.	PUNCT
fnp-3806	1253	1	the	the	DET
fnp-3806	1253	2	identification	identification	NOUN
fnp-3806	1253	3	of	of	ADP
fnp-3806	1253	4	new	new	ADJ
fnp-3806	1253	5	putative	putative	ADJ
fnp-3806	1253	6	targets	target	NOUN
fnp-3806	1253	7	for	for	ADP
fnp-3806	1253	8	therapeutic	therapeutic	ADJ
fnp-3806	1253	9	intervention	intervention	NOUN
fnp-3806	1253	10	before	before	ADP
fnp-3806	1253	11	the	the	DET
fnp-3806	1253	12	appearance	appearance	NOUN
fnp-3806	1253	13	of	of	ADP
fnp-3806	1253	14	tau	tau	PROPN
fnp-3806	1253	15	and	and	CCONJ
fnp-3806	1253	16	amyloid	amyloid	NOUN
fnp-3806	1253	17	deposits	deposit	NOUN
fnp-3806	1253	18	is	be	AUX
fnp-3806	1253	19	a	a	DET
fnp-3806	1253	20	promising	promising	ADJ
fnp-3806	1253	21	endeavor	endeavor	NOUN
fnp-3806	1253	22	.	.	PUNCT
fnp-3806	1254	1	gene	gene	NOUN
fnp-3806	1254	2	therapy	therapy	NOUN
fnp-3806	1254	3	has	have	AUX
fnp-3806	1254	4	also	also	ADV
fnp-3806	1254	5	been	be	AUX
fnp-3806	1254	6	assessed	assess	VERB
fnp-3806	1254	7	in	in	ADP
fnp-3806	1254	8	transgenic	transgenic	NOUN
fnp-3806	1254	9	mouse	mouse	NOUN
fnp-3806	1254	10	models	model	NOUN
fnp-3806	1254	11	with	with	ADP
fnp-3806	1254	12	variable	variable	ADJ
fnp-3806	1254	13	success	success	NOUN
fnp-3806	1254	14	using	use	VERB
fnp-3806	1254	15	both	both	CCONJ
fnp-3806	1254	16	vector	vector	NOUN
fnp-3806	1254	17	-	-	PUNCT
fnp-3806	1254	18	based	base	VERB
fnp-3806	1254	19	therapies	therapy	NOUN
fnp-3806	1254	20	and	and	CCONJ
fnp-3806	1254	21	genetically	genetically	ADV
fnp-3806	1254	22	modified	modify	VERB
fnp-3806	1254	23	cell	cell	NOUN
fnp-3806	1254	24	replacement	replacement	NOUN
fnp-3806	1254	25	(	(	PUNCT
fnp-3806	1254	26	1540	1540	NUM
fnp-3806	1254	27	-	-	SYM
fnp-3806	1254	28	1542	1542	NUM
fnp-3806	1254	29	)	)	PUNCT
fnp-3806	1254	30	.	.	PUNCT
fnp-3806	1255	1	studies	study	NOUN
fnp-3806	1255	2	in	in	ADP
fnp-3806	1255	3	humans	human	NOUN
fnp-3806	1255	4	are	be	AUX
fnp-3806	1255	5	limited	limit	VERB
fnp-3806	1255	6	,	,	PUNCT
fnp-3806	1255	7	at	at	ADP
fnp-3806	1255	8	this	this	DET
fnp-3806	1255	9	time	time	NOUN
fnp-3806	1255	10	,	,	PUNCT
fnp-3806	1255	11	to	to	PART
fnp-3806	1255	12	upregulated	upregulate	VERB
fnp-3806	1255	13	ngf	ngf	ADV
fnp-3806	1255	14	in	in	ADP
fnp-3806	1255	15	sad	sad	ADJ
fnp-3806	1255	16	patients	patient	NOUN
fnp-3806	1255	17	,	,	PUNCT
fnp-3806	1255	18	with	with	ADP
fnp-3806	1255	19	little	little	ADJ
fnp-3806	1255	20	evidence	evidence	NOUN
fnp-3806	1255	21	of	of	ADP
fnp-3806	1255	22	benefit	benefit	NOUN
fnp-3806	1255	23	(	(	PUNCT
fnp-3806	1255	24	1543	1543	NUM
fnp-3806	1255	25	-	-	SYM
fnp-3806	1255	26	1545	1545	NUM
fnp-3806	1255	27	)	)	PUNCT
fnp-3806	1255	28	.	.	PUNCT
fnp-3806	1256	1	exosomes	exosome	NOUN
fnp-3806	1256	2	are	be	AUX
fnp-3806	1256	3	a	a	DET
fnp-3806	1256	4	class	class	NOUN
fnp-3806	1256	5	of	of	ADP
fnp-3806	1256	6	membrane	membrane	NOUN
fnp-3806	1256	7	vesicles	vesicle	NOUN
fnp-3806	1256	8	derived	derive	VERB
fnp-3806	1256	9	from	from	ADP
fnp-3806	1256	10	endolysosomal	endolysosomal	ADJ
fnp-3806	1256	11	compartment	compartment	NOUN
fnp-3806	1256	12	implicated	implicate	VERB
fnp-3806	1256	13	in	in	ADP
fnp-3806	1256	14	cell	cell	NOUN
fnp-3806	1256	15	-	-	PUNCT
fnp-3806	1256	16	cell	cell	NOUN
fnp-3806	1256	17	communication	communication	NOUN
fnp-3806	1256	18	by	by	ADP
fnp-3806	1256	19	shuttling	shuttle	VERB
fnp-3806	1256	20	different	different	ADJ
fnp-3806	1256	21	lipids	lipid	NOUN
fnp-3806	1256	22	,	,	PUNCT
fnp-3806	1256	23	protein	protein	NOUN
fnp-3806	1256	24	,	,	PUNCT
fnp-3806	1256	25	and	and	CCONJ
fnp-3806	1256	26	rnas	rna	NOUN
fnp-3806	1256	27	between	between	ADP
fnp-3806	1256	28	cells	cell	NOUN
fnp-3806	1256	29	.	.	PUNCT
fnp-3806	1257	1	the	the	DET
fnp-3806	1257	2	use	use	NOUN
fnp-3806	1257	3	of	of	ADP
fnp-3806	1257	4	shuttles	shuttle	NOUN
fnp-3806	1257	5	including	include	VERB
fnp-3806	1257	6	exosomes	exosome	NOUN
fnp-3806	1257	7	to	to	PART
fnp-3806	1257	8	deliver	deliver	VERB
fnp-3806	1257	9	selected	select	VERB
fnp-3806	1257	10	molecules	molecule	NOUN
fnp-3806	1257	11	into	into	ADP
fnp-3806	1257	12	the	the	DET
fnp-3806	1257	13	cells	cell	NOUN
fnp-3806	1257	14	is	be	AUX
fnp-3806	1257	15	still	still	ADV
fnp-3806	1257	16	at	at	ADP
fnp-3806	1257	17	the	the	DET
fnp-3806	1257	18	early	early	ADJ
fnp-3806	1257	19	stages	stage	NOUN
fnp-3806	1257	20	.	.	PUNCT
fnp-3806	1258	1	the	the	DET
fnp-3806	1258	2	meager	meager	ADJ
fnp-3806	1258	3	success	success	NOUN
fnp-3806	1258	4	of	of	ADP
fnp-3806	1258	5	available	available	ADJ
fnp-3806	1258	6	therapies	therapy	NOUN
fnp-3806	1258	7	to	to	PART
fnp-3806	1258	8	curb	curb	VERB
fnp-3806	1258	9	the	the	DET
fnp-3806	1258	10	effects	effect	NOUN
fnp-3806	1258	11	of	of	ADP
fnp-3806	1258	12	human	human	ADJ
fnp-3806	1258	13	brain	brain	NOUN
fnp-3806	1258	14	aging	aging	NOUN
fnp-3806	1258	15	and	and	CCONJ
fnp-3806	1258	16	sad	sad	ADJ
fnp-3806	1258	17	is	be	AUX
fnp-3806	1258	18	a	a	DET
fnp-3806	1258	19	matter	matter	NOUN
fnp-3806	1258	20	of	of	ADP
fnp-3806	1258	21	concern	concern	NOUN
fnp-3806	1258	22	.	.	PUNCT
fnp-3806	1259	1	besides	besides	SCONJ
fnp-3806	1259	2	disease	disease	NOUN
fnp-3806	1259	3	modification	modification	NOUN
fnp-3806	1259	4	and	and	CCONJ
fnp-3806	1259	5	symptomatic	symptomatic	ADJ
fnp-3806	1259	6	therapies	therapy	NOUN
fnp-3806	1259	7	for	for	ADP
fnp-3806	1259	8	sad	sad	ADJ
fnp-3806	1259	9	(	(	PUNCT
fnp-3806	1259	10	1546	1546	NUM
fnp-3806	1259	11	-	-	SYM
fnp-3806	1259	12	1549	1549	NUM
fnp-3806	1259	13	)	)	PUNCT
fnp-3806	1259	14	,	,	PUNCT
fnp-3806	1259	15	other	other	ADJ
fnp-3806	1259	16	relevant	relevant	ADJ
fnp-3806	1259	17	and	and	CCONJ
fnp-3806	1259	18	long	long	ADJ
fnp-3806	1259	19	-	-	PUNCT
fnp-3806	1259	20	term	term	NOUN
fnp-3806	1259	21	ventures	venture	NOUN
fnp-3806	1259	22	may	may	AUX
fnp-3806	1259	23	also	also	ADV
fnp-3806	1259	24	be	be	AUX
fnp-3806	1259	25	considered	consider	VERB
fnp-3806	1259	26	.	.	PUNCT
fnp-3806	1260	1	one	one	NUM
fnp-3806	1260	2	of	of	ADP
fnp-3806	1260	3	these	these	PRON
fnp-3806	1260	4	is	be	AUX
fnp-3806	1260	5	a	a	DET
fnp-3806	1260	6	revision	revision	NOUN
fnp-3806	1260	7	of	of	ADP
fnp-3806	1260	8	animal	animal	NOUN
fnp-3806	1260	9	models	model	NOUN
fnp-3806	1260	10	used	use	VERB
fnp-3806	1260	11	to	to	PART
fnp-3806	1260	12	test	test	VERB
fnp-3806	1260	13	sad	sad	ADJ
fnp-3806	1260	14	therapies	therapy	NOUN
fnp-3806	1260	15	,	,	PUNCT
fnp-3806	1260	16	because	because	SCONJ
fnp-3806	1260	17	they	they	PRON
fnp-3806	1260	18	have	have	AUX
fnp-3806	1260	19	failed	fail	VERB
fnp-3806	1260	20	when	when	SCONJ
fnp-3806	1260	21	applied	apply	VERB
fnp-3806	1260	22	to	to	ADP
fnp-3806	1260	23	humans	human	NOUN
fnp-3806	1260	24	(	(	PUNCT
fnp-3806	1260	25	1550	1550	NUM
fnp-3806	1260	26	)	)	PUNCT
fnp-3806	1260	27	.	.	PUNCT
fnp-3806	1261	1	to	to	PART
fnp-3806	1261	2	make	make	VERB
fnp-3806	1261	3	this	this	PRON
fnp-3806	1261	4	clear	clear	ADJ
fnp-3806	1261	5	:	:	PUNCT
fnp-3806	1261	6	for	for	ADP
fnp-3806	1261	7	25	25	NUM
fnp-3806	1261	8	years	year	NOUN
fnp-3806	1261	9	,	,	PUNCT
fnp-3806	1261	10	many	many	ADJ
fnp-3806	1261	11	ad	ad	NOUN
fnp-3806	1261	12	-	-	PUNCT
fnp-3806	1261	13	like	like	ADJ
fnp-3806	1261	14	mouse	mouse	NOUN
fnp-3806	1261	15	models	model	NOUN
fnp-3806	1261	16	have	have	AUX
fnp-3806	1261	17	been	be	AUX
fnp-3806	1261	18	“	"	PUNCT
fnp-3806	1261	19	cured	cure	VERB
fnp-3806	1261	20	”	"	PUNCT
fnp-3806	1261	21	in	in	ADP
fnp-3806	1261	22	the	the	DET
fnp-3806	1261	23	lab	lab	NOUN
fnp-3806	1261	24	,	,	PUNCT
fnp-3806	1261	25	only	only	ADV
fnp-3806	1261	26	for	for	SCONJ
fnp-3806	1261	27	the	the	DET
fnp-3806	1261	28	treatments	treatment	NOUN
fnp-3806	1261	29	to	to	PART
fnp-3806	1261	30	fail	fail	VERB
fnp-3806	1261	31	in	in	ADP
fnp-3806	1261	32	clinical	clinical	ADJ
fnp-3806	1261	33	trials	trial	NOUN
fnp-3806	1261	34	in	in	ADP
fnp-3806	1261	35	humans	human	NOUN
fnp-3806	1261	36	(	(	PUNCT
fnp-3806	1261	37	1551	1551	NUM
fnp-3806	1261	38	,	,	PUNCT
fnp-3806	1261	39	1552	1552	NUM
fnp-3806	1261	40	)	)	PUNCT
fnp-3806	1261	41	.	.	PUNCT
fnp-3806	1262	1	it	it	PRON
fnp-3806	1262	2	seems	seem	VERB
fnp-3806	1262	3	that	that	SCONJ
fnp-3806	1262	4	mice	mouse	NOUN
fnp-3806	1262	5	have	have	VERB
fnp-3806	1262	6	the	the	DET
fnp-3806	1262	7	ability	ability	NOUN
fnp-3806	1262	8	to	to	PART
fnp-3806	1262	9	remodel	remodel	VERB
fnp-3806	1262	10	complex	complex	ADJ
fnp-3806	1262	11	metabolic	metabolic	NOUN
fnp-3806	1262	12	defects	defect	NOUN
fnp-3806	1262	13	once	once	SCONJ
fnp-3806	1262	14	one	one	NUM
fnp-3806	1262	15	of	of	ADP
fnp-3806	1262	16	the	the	DET
fnp-3806	1262	17	factors	factor	NOUN
fnp-3806	1262	18	involved	involve	VERB
fnp-3806	1262	19	in	in	ADP
fnp-3806	1262	20	the	the	DET
fnp-3806	1262	21	process	process	NOUN
fnp-3806	1262	22	is	be	AUX
fnp-3806	1262	23	normalized	normalize	VERB
fnp-3806	1262	24	.	.	PUNCT
fnp-3806	1263	1	this	this	PRON
fnp-3806	1263	2	does	do	AUX
fnp-3806	1263	3	not	not	PART
fnp-3806	1263	4	occur	occur	VERB
fnp-3806	1263	5	in	in	ADP
fnp-3806	1263	6	humans	human	NOUN
fnp-3806	1263	7	.	.	PUNCT
fnp-3806	1264	1	these	these	DET
fnp-3806	1264	2	considerations	consideration	NOUN
fnp-3806	1264	3	are	be	AUX
fnp-3806	1264	4	made	make	VERB
fnp-3806	1264	5	yet	yet	ADV
fnp-3806	1264	6	more	more	ADV
fnp-3806	1264	7	compulsory	compulsory	ADJ
fnp-3806	1264	8	because	because	SCONJ
fnp-3806	1264	9	a	a	DET
fnp-3806	1264	10	number	number	NOUN
fnp-3806	1264	11	of	of	ADP
fnp-3806	1264	12	molecular	molecular	ADJ
fnp-3806	1264	13	function	function	NOUN
fnp-3806	1264	14	derangements	derangement	NOUN
fnp-3806	1264	15	take	take	VERB
fnp-3806	1264	16	place	place	NOUN
fnp-3806	1264	17	before	before	ADP
fnp-3806	1264	18	or	or	CCONJ
fnp-3806	1264	19	concurrent	concurrent	ADJ
fnp-3806	1264	20	with	with	ADP
fnp-3806	1264	21	the	the	DET
fnp-3806	1264	22	appearance	appearance	NOUN
fnp-3806	1264	23	of	of	ADP
fnp-3806	1264	24	β	β	NOUN
fnp-3806	1264	25	-	-	NOUN
fnp-3806	1264	26	amyloid	amyloid	NOUN
fnp-3806	1264	27	and	and	CCONJ
fnp-3806	1264	28	tau	tau	PROPN
fnp-3806	1264	29	pathology	pathology	NOUN
fnp-3806	1264	30	morphologically	morphologically	ADV
fnp-3806	1264	31	manifested	manifest	VERB
fnp-3806	1264	32	as	as	ADP
fnp-3806	1264	33	nfts	nft	NOUN
fnp-3806	1264	34	and	and	CCONJ
fnp-3806	1264	35	sps	sps	PROPN
fnp-3806	1264	36	.	.	PUNCT
fnp-3806	1265	1	altered	alter	VERB
fnp-3806	1265	2	lipid	lipid	NOUN
fnp-3806	1265	3	and	and	CCONJ
fnp-3806	1265	4	protein	protein	NOUN
fnp-3806	1265	5	composition	composition	NOUN
fnp-3806	1265	6	of	of	ADP
fnp-3806	1265	7	cellular	cellular	ADJ
fnp-3806	1265	8	membranes	membrane	NOUN
fnp-3806	1265	9	accompanied	accompany	VERB
fnp-3806	1265	10	by	by	ADP
fnp-3806	1265	11	impaired	impaired	ADJ
fnp-3806	1265	12	subcellular	subcellular	ADJ
fnp-3806	1265	13	cell	cell	NOUN
fnp-3806	1265	14	signaling	signal	VERB
fnp-3806	1265	15	from	from	ADP
fnp-3806	1265	16	the	the	DET
fnp-3806	1265	17	cell	cell	NOUN
fnp-3806	1265	18	membrane	membrane	NOUN
fnp-3806	1265	19	to	to	ADP
fnp-3806	1265	20	the	the	DET
fnp-3806	1265	21	er	er	INTJ
fnp-3806	1265	22	,	,	PUNCT
fnp-3806	1265	23	mitochondrial	mitochondrial	ADJ
fnp-3806	1265	24	membranes	membrane	NOUN
fnp-3806	1265	25	,	,	PUNCT
fnp-3806	1265	26	altered	alter	VERB
fnp-3806	1265	27	synapses	synapsis	NOUN
fnp-3806	1265	28	,	,	PUNCT
fnp-3806	1265	29	altered	alter	VERB
fnp-3806	1265	30	mitochondria	mitochondria	NOUN
fnp-3806	1265	31	and	and	CCONJ
fnp-3806	1265	32	energy	energy	NOUN
fnp-3806	1265	33	metabolism	metabolism	NOUN
fnp-3806	1265	34	,	,	PUNCT
fnp-3806	1265	35	and	and	CCONJ
fnp-3806	1265	36	reactivation	reactivation	NOUN
fnp-3806	1265	37	and	and	CCONJ
fnp-3806	1265	38	abortion	abortion	NOUN
fnp-3806	1265	39	of	of	ADP
fnp-3806	1265	40	developmental	developmental	ADJ
fnp-3806	1265	41	programs	program	NOUN
fnp-3806	1265	42	leading	lead	VERB
fnp-3806	1265	43	to	to	ADP
fnp-3806	1265	44	neuronal	neuronal	ADJ
fnp-3806	1265	45	death	death	NOUN
fnp-3806	1265	46	,	,	PUNCT
fnp-3806	1265	47	together	together	ADV
fnp-3806	1265	48	with	with	ADP
fnp-3806	1265	49	dysfunctional	dysfunctional	ADJ
fnp-3806	1265	50	bbb	bbb	NOUN
fnp-3806	1265	51	and	and	CCONJ
fnp-3806	1265	52	singular	singular	PROPN
fnp-3806	1265	53	brain	brain	NOUN
fnp-3806	1265	54	inflammatory	inflammatory	ADJ
fnp-3806	1265	55	expression	expression	NOUN
fnp-3806	1265	56	,	,	PUNCT
fnp-3806	1265	57	all	all	PRON
fnp-3806	1265	58	point	point	VERB
fnp-3806	1265	59	to	to	PART
fnp-3806	1265	60	sad	sad	ADJ
fnp-3806	1265	61	as	as	ADP
fnp-3806	1265	62	a	a	DET
fnp-3806	1265	63	human	human	ADJ
fnp-3806	1265	64	brain	brain	NOUN
fnp-3806	1265	65	age	age	NOUN
fnp-3806	1265	66	-	-	PUNCT
fnp-3806	1265	67	related	relate	VERB
fnp-3806	1265	68	disorder	disorder	NOUN
fnp-3806	1265	69	of	of	ADP
fnp-3806	1265	70	convergent	convergent	NOUN
fnp-3806	1265	71	mechanisms	mechanism	NOUN
fnp-3806	1265	72	that	that	PRON
fnp-3806	1265	73	shatters	shatter	VERB
fnp-3806	1265	74	brain	brain	NOUN
fnp-3806	1265	75	self	self	NOUN
fnp-3806	1265	76	-	-	PUNCT
fnp-3806	1265	77	organization	organization	NOUN
fnp-3806	1265	78	(	(	PUNCT
fnp-3806	1265	79	329	329	NUM
fnp-3806	1265	80	,	,	PUNCT
fnp-3806	1265	81	1343	1343	NUM
fnp-3806	1265	82	,	,	PUNCT
fnp-3806	1265	83	1553	1553	NUM
fnp-3806	1265	84	,	,	PUNCT
fnp-3806	1265	85	1554	1554	NUM
fnp-3806	1265	86	)	)	PUNCT
fnp-3806	1265	87	.	.	PUNCT
fnp-3806	1266	1	a	a	DET
fnp-3806	1266	2	great	great	ADJ
fnp-3806	1266	3	data	data	NOUN
fnp-3806	1266	4	analysis	analysis	NOUN
fnp-3806	1266	5	covering	cover	VERB
fnp-3806	1266	6	the	the	DET
fnp-3806	1266	7	tremendous	tremendous	ADJ
fnp-3806	1266	8	body	body	NOUN
fnp-3806	1266	9	of	of	ADP
fnp-3806	1266	10	information	information	NOUN
fnp-3806	1266	11	on	on	ADP
fnp-3806	1266	12	ad	ad	NOUN
fnp-3806	1266	13	must	must	AUX
fnp-3806	1266	14	be	be	AUX
fnp-3806	1266	15	updated	update	VERB
fnp-3806	1266	16	in	in	ADP
fnp-3806	1266	17	real	real	ADJ
fnp-3806	1266	18	time	time	NOUN
fnp-3806	1266	19	.	.	PUNCT
fnp-3806	1267	1	we	we	PRON
fnp-3806	1267	2	need	need	VERB
fnp-3806	1267	3	to	to	PART
fnp-3806	1267	4	think	think	VERB
fnp-3806	1267	5	of	of	ADP
fnp-3806	1267	6	the	the	DET
fnp-3806	1267	7	coming	come	VERB
fnp-3806	1267	8	decades	decade	NOUN
fnp-3806	1267	9	as	as	ADP
fnp-3806	1267	10	an	an	DET
fnp-3806	1267	11	opportunity	opportunity	NOUN
fnp-3806	1267	12	to	to	PART
fnp-3806	1267	13	take	take	VERB
fnp-3806	1267	14	advantage	advantage	NOUN
fnp-3806	1267	15	of	of	ADP
fnp-3806	1267	16	the	the	DET
fnp-3806	1267	17	rapid	rapid	ADJ
fnp-3806	1267	18	growth	growth	NOUN
fnp-3806	1267	19	of	of	ADP
fnp-3806	1267	20	artificial	artificial	ADJ
fnp-3806	1267	21	intelligence	intelligence	NOUN
fnp-3806	1267	22	(	(	PUNCT
fnp-3806	1267	23	ai	ai	NOUN
fnp-3806	1267	24	)	)	PUNCT
fnp-3806	1267	25	and	and	CCONJ
fnp-3806	1267	26	cell	cell	NOUN
fnp-3806	1267	27	reprogramming	reprogramming	NOUN
fnp-3806	1267	28	.	.	PUNCT
fnp-3806	1268	1	we	we	PRON
fnp-3806	1268	2	will	will	AUX
fnp-3806	1268	3	be	be	AUX
fnp-3806	1268	4	able	able	ADJ
fnp-3806	1268	5	to	to	PART
fnp-3806	1268	6	redesign	redesign	VERB
fnp-3806	1268	7	some	some	DET
fnp-3806	1268	8	aspects	aspect	NOUN
fnp-3806	1268	9	of	of	ADP
fnp-3806	1268	10	the	the	DET
fnp-3806	1268	11	human	human	ADJ
fnp-3806	1268	12	brain	brain	NOUN
fnp-3806	1268	13	in	in	ADP
fnp-3806	1268	14	the	the	DET
fnp-3806	1268	15	near	near	ADJ
fnp-3806	1268	16	future	future	NOUN
fnp-3806	1268	17	using	use	VERB
fnp-3806	1268	18	advanced	advanced	ADJ
fnp-3806	1268	19	technologies	technology	NOUN
fnp-3806	1268	20	.	.	PUNCT
fnp-3806	1269	1	to	to	ADP
fnp-3806	1269	2	this	this	DET
fnp-3806	1269	3	end	end	NOUN
fnp-3806	1269	4	,	,	PUNCT
fnp-3806	1269	5	we	we	PRON
fnp-3806	1269	6	also	also	ADV
fnp-3806	1269	7	need	need	VERB
fnp-3806	1269	8	to	to	PART
fnp-3806	1269	9	identify	identify	VERB
fnp-3806	1269	10	the	the	DET
fnp-3806	1269	11	main	main	ADJ
fnp-3806	1269	12	targets	target	NOUN
fnp-3806	1269	13	and	and	CCONJ
fnp-3806	1269	14	appropriate	appropriate	ADJ
fnp-3806	1269	15	intervention	intervention	NOUN
fnp-3806	1269	16	times	time	NOUN
fnp-3806	1269	17	.	.	PUNCT
fnp-3806	1270	1	timing	timing	NOUN
fnp-3806	1270	2	is	be	AUX
fnp-3806	1270	3	crucial	crucial	ADJ
fnp-3806	1270	4	since	since	SCONJ
fnp-3806	1270	5	it	it	PRON
fnp-3806	1270	6	will	will	AUX
fnp-3806	1270	7	be	be	AUX
fnp-3806	1270	8	difficult	difficult	ADJ
fnp-3806	1270	9	to	to	PART
fnp-3806	1270	10	reprogram	reprogram	VERB
fnp-3806	1270	11	molecular	molecular	ADJ
fnp-3806	1270	12	pathways	pathway	NOUN
fnp-3806	1270	13	in	in	ADP
fnp-3806	1270	14	old	old	ADJ
fnp-3806	1270	15	-	-	PUNCT
fnp-3806	1270	16	adult	adult	NOUN
fnp-3806	1270	17	individuals	individual	NOUN
fnp-3806	1270	18	that	that	PRON
fnp-3806	1270	19	have	have	AUX
fnp-3806	1270	20	already	already	ADV
fnp-3806	1270	21	suffered	suffer	VERB
fnp-3806	1270	22	brain	brain	NOUN
fnp-3806	1270	23	deterioration	deterioration	NOUN
fnp-3806	1270	24	.	.	PUNCT
fnp-3806	1271	1	brain	brain	NOUN
fnp-3806	1271	2	reprogramming	reprogramme	VERB
fnp-3806	1271	3	would	would	AUX
fnp-3806	1271	4	likely	likely	ADV
fnp-3806	1271	5	be	be	AUX
fnp-3806	1271	6	undertaken	undertake	VERB
fnp-3806	1271	7	before	before	ADP
fnp-3806	1271	8	the	the	DET
fnp-3806	1271	9	beginning	beginning	NOUN
fnp-3806	1271	10	of	of	ADP
fnp-3806	1271	11	the	the	DET
fnp-3806	1271	12	slow	slow	ADJ
fnp-3806	1271	13	-	-	PUNCT
fnp-3806	1271	14	pace	pace	NOUN
fnp-3806	1271	15	functional	functional	ADJ
fnp-3806	1271	16	decline	decline	NOUN
fnp-3806	1271	17	in	in	ADP
fnp-3806	1271	18	ma	ma	PROPN
fnp-3806	1271	19	adults	adult	NOUN
fnp-3806	1271	20	.	.	PUNCT
fnp-3806	1272	1	brain	brain	NOUN
fnp-3806	1272	2	reprogramming	reprogramme	VERB
fnp-3806	1272	3	may	may	AUX
fnp-3806	1272	4	cover	cover	VERB
fnp-3806	1272	5	different	different	ADJ
fnp-3806	1272	6	areas	area	NOUN
fnp-3806	1272	7	including	include	VERB
fnp-3806	1272	8	brain	brain	NOUN
fnp-3806	1272	9	dna	dna	PROPN
fnp-3806	1272	10	editing	editing	NOUN
fnp-3806	1272	11	,	,	PUNCT
fnp-3806	1272	12	utilization	utilization	NOUN
fnp-3806	1272	13	of	of	ADP
fnp-3806	1272	14	external	external	ADJ
fnp-3806	1272	15	electrical	electrical	ADJ
fnp-3806	1272	16	or	or	CCONJ
fnp-3806	1272	17	wave	wave	NOUN
fnp-3806	1272	18	-	-	PUNCT
fnp-3806	1272	19	based	base	VERB
fnp-3806	1272	20	signals	signal	NOUN
fnp-3806	1272	21	to	to	PART
fnp-3806	1272	22	reduce	reduce	VERB
fnp-3806	1272	23	energy	energy	NOUN
fnp-3806	1272	24	consumption	consumption	NOUN
fnp-3806	1272	25	of	of	ADP
fnp-3806	1272	26	basic	basic	ADJ
fnp-3806	1272	27	neuronal	neuronal	ADJ
fnp-3806	1272	28	networks	network	NOUN
fnp-3806	1272	29	,	,	PUNCT
fnp-3806	1272	30	optimization	optimization	NOUN
fnp-3806	1272	31	of	of	ADP
fnp-3806	1272	32	mitochondrial	mitochondrial	ADJ
fnp-3806	1272	33	function	function	NOUN
fnp-3806	1272	34	,	,	PUNCT
fnp-3806	1272	35	implanting	implanting	NOUN
fnp-3806	1272	36	of	of	ADP
fnp-3806	1272	37	microdevices	microdevice	NOUN
fnp-3806	1272	38	to	to	PART
fnp-3806	1272	39	facilitate	facilitate	VERB
fnp-3806	1272	40	cooperative	cooperative	ADJ
fnp-3806	1272	41	human	human	ADJ
fnp-3806	1272	42	-	-	PUNCT
fnp-3806	1272	43	machine	machine	NOUN
fnp-3806	1272	44	function	function	NOUN
fnp-3806	1272	45	,	,	PUNCT
fnp-3806	1272	46	pharmacological	pharmacological	ADJ
fnp-3806	1272	47	combined	combine	VERB
fnp-3806	1272	48	protection	protection	NOUN
fnp-3806	1272	49	of	of	ADP
fnp-3806	1272	50	lipid	lipid	NOUN
fnp-3806	1272	51	-	-	PUNCT
fnp-3806	1272	52	protein	protein	NOUN
fnp-3806	1272	53	interactions	interaction	NOUN
fnp-3806	1272	54	,	,	PUNCT
fnp-3806	1272	55	and	and	CCONJ
fnp-3806	1272	56	program	program	NOUN
fnp-3806	1272	57	resetting	reset	VERB
fnp-3806	1272	58	during	during	ADP
fnp-3806	1272	59	stages	stage	NOUN
fnp-3806	1272	60	of	of	ADP
fnp-3806	1272	61	sleep	sleep	NOUN
fnp-3806	1272	62	.	.	PUNCT
fnp-3806	1273	1	improvement	improvement	NOUN
fnp-3806	1273	2	of	of	ADP
fnp-3806	1273	3	brain	brain	NOUN
fnp-3806	1273	4	function	function	NOUN
fnp-3806	1273	5	in	in	ADP
fnp-3806	1273	6	aging	age	VERB
fnp-3806	1273	7	and	and	CCONJ
fnp-3806	1273	8	sad	sad	ADJ
fnp-3806	1273	9	has	have	VERB
fnp-3806	1273	10	a	a	DET
fnp-3806	1273	11	chance	chance	NOUN
fnp-3806	1273	12	in	in	ADP
fnp-3806	1273	13	the	the	DET
fnp-3806	1273	14	application	application	NOUN
fnp-3806	1273	15	of	of	ADP
fnp-3806	1273	16	high	high	ADJ
fnp-3806	1273	17	-	-	PUNCT
fnp-3806	1273	18	throughput	throughput	NOUN
fnp-3806	1273	19	molecular	molecular	ADJ
fnp-3806	1273	20	technology	technology	NOUN
fnp-3806	1273	21	,	,	PUNCT
fnp-3806	1273	22	ai	ai	VERB
fnp-3806	1273	23	,	,	PUNCT
fnp-3806	1273	24	and	and	CCONJ
fnp-3806	1273	25	robotics	robotic	NOUN
fnp-3806	1273	26	(	(	PUNCT
fnp-3806	1273	27	1394	1394	NUM
fnp-3806	1273	28	,	,	PUNCT
fnp-3806	1273	29	1555	1555	NUM
fnp-3806	1273	30	-	-	SYM
fnp-3806	1273	31	1561	1561	NUM
fnp-3806	1273	32	)	)	PUNCT
fnp-3806	1273	33	.	.	PUNCT
fnp-3806	1274	1	this	this	DET
fnp-3806	1274	2	new	new	ADJ
fnp-3806	1274	3	era	era	NOUN
fnp-3806	1274	4	is	be	AUX
fnp-3806	1274	5	certain	certain	ADJ
fnp-3806	1274	6	to	to	PART
fnp-3806	1274	7	present	present	VERB
fnp-3806	1274	8	formidable	formidable	ADJ
fnp-3806	1274	9	ethical	ethical	ADJ
fnp-3806	1274	10	challenges	challenge	NOUN
fnp-3806	1274	11	.	.	PUNCT
fnp-3806	1275	1	abbbreviations	abbbreviation	NOUN
fnp-3806	1275	2	2	2	NUM
fnp-3806	1275	3	-	-	PUNCT
fnp-3806	1275	4	ag	ag	ADJ
fnp-3806	1275	5	arachidonoyl	arachidonoyl	NOUN
fnp-3806	1275	6	glycerol	glycerol	NOUN
fnp-3806	1275	7	,	,	PUNCT
fnp-3806	1275	8	5	5	NUM
fnp-3806	1275	9	-	-	SYM
fnp-3806	1275	10	ht	ht	PROPN
fnp-3806	1275	11	5	5	NUM
fnp-3806	1275	12	-	-	PUNCT
fnp-3806	1275	13	hydroxytriptamine	hydroxytriptamine	NOUN
fnp-3806	1275	14	,	,	PUNCT
fnp-3806	1275	15	3’-utr	3’-utr	NUM
fnp-3806	1275	16	complementary	complementary	ADJ
fnp-3806	1275	17	un	un	ADJ
fnp-3806	1275	18	-	-	ADJ
fnp-3806	1275	19	translated	translate	VERB
fnp-3806	1275	20	regions	region	NOUN
fnp-3806	1275	21	,	,	PUNCT
fnp-3806	1275	22	aa	aa	ADJ
fnp-3806	1275	23	arachidonic	arachidonic	ADJ
fnp-3806	1275	24	acid	acid	NOUN
fnp-3806	1275	25	,	,	PUNCT
fnp-3806	1275	26	aβ	aβ	ADP
fnp-3806	1275	27	beta	beta	NOUN
fnp-3806	1275	28	amyloid	amyloid	NOUN
fnp-3806	1275	29	,	,	PUNCT
fnp-3806	1275	30	abca7	abca7	PROPN
fnp-3806	1275	31	atp	atp	PROPN
fnp-3806	1275	32	binding	bind	VERB
fnp-3806	1275	33	cassette	cassette	NOUN
fnp-3806	1275	34	subfamily	subfamily	ADV
fnp-3806	1275	35	a	a	DET
fnp-3806	1275	36	member	member	NOUN
fnp-3806	1275	37	7	7	NUM
fnp-3806	1275	38	,	,	PUNCT
fnp-3806	1275	39	aβos	aβos	PROPN
fnp-3806	1275	40	soluble	soluble	ADJ
fnp-3806	1275	41	β	β	NOUN
fnp-3806	1275	42	-	-	ADJ
fnp-3806	1275	43	amyloid	amyloid	ADJ
fnp-3806	1275	44	oligomers	oligomer	NOUN
fnp-3806	1275	45	,	,	PUNCT
fnp-3806	1275	46	ac	ac	PROPN
fnp-3806	1275	47	adenylyl	adenylyl	PROPN
fnp-3806	1275	48	cyclise	cyclise	NOUN
fnp-3806	1275	49	,	,	PUNCT
fnp-3806	1275	50	ach	ach	NOUN
fnp-3806	1275	51	acetylcholine	acetylcholine	NOUN
fnp-3806	1275	52	,	,	PUNCT
fnp-3806	1275	53	ache	ache	ADV
fnp-3806	1275	54	acetylcholinesterase	acetylcholinesterase	NOUN
fnp-3806	1275	55	,	,	PUNCT
fnp-3806	1275	56	ad	ad	NOUN
fnp-3806	1275	57	alzheimer	alzheimer	NOUN
fnp-3806	1275	58	disease	disease	NOUN
fnp-3806	1275	59	,	,	PUNCT
fnp-3806	1275	60	adam10	adam10	PROPN
fnp-3806	1275	61	adam	adam	PROPN
fnp-3806	1275	62	metallopeptidase	metallopeptidase	PROPN
fnp-3806	1275	63	domain	domain	NOUN
fnp-3806	1275	64	10	10	NUM
fnp-3806	1275	65	,	,	PUNCT
fnp-3806	1275	66	addls	addls	PROPN
fnp-3806	1275	67	amyloid	amyloid	NOUN
fnp-3806	1275	68	-	-	PUNCT
fnp-3806	1275	69	β	β	NOUN
fnp-3806	1275	70	derived	derive	VERB
fnp-3806	1275	71	diffusible	diffusible	ADJ
fnp-3806	1275	72	ligands	ligand	NOUN
fnp-3806	1275	73	,	,	PUNCT
fnp-3806	1275	74	adnc	adnc	ADJ
fnp-3806	1275	75	ad	ad	NOUN
fnp-3806	1275	76	-	-	PUNCT
fnp-3806	1275	77	neuropathologic	neuropathologic	NOUN
fnp-3806	1275	78	change	change	NOUN
fnp-3806	1275	79	,	,	PUNCT
fnp-3806	1275	80	aea	aea	PROPN
fnp-3806	1275	81	n	n	CCONJ
fnp-3806	1275	82	-	-	PUNCT
fnp-3806	1275	83	arachidonoyl	arachidonoyl	ADJ
fnp-3806	1275	84	ethanolamine	ethanolamine	NOUN
fnp-3806	1275	85	,	,	PUNCT
fnp-3806	1275	86	agd	agd	PROPN
fnp-3806	1275	87	argyrophylic	argyrophylic	ADJ
fnp-3806	1275	88	grain	grain	NOUN
fnp-3806	1275	89	disease	disease	NOUN
fnp-3806	1275	90	,	,	PUNCT
fnp-3806	1275	91	ages	age	NOUN
fnp-3806	1275	92	advanced	advanced	ADJ
fnp-3806	1275	93	glycation	glycation	NOUN
fnp-3806	1275	94	end	end	NOUN
fnp-3806	1275	95	-	-	PUNCT
fnp-3806	1275	96	products	product	NOUN
fnp-3806	1275	97	,	,	PUNCT
fnp-3806	1275	98	ago	ago	ADV
fnp-3806	1275	99	argonaute	argonaute	VERB
fnp-3806	1275	100	subfamily	subfamily	ADJ
fnp-3806	1275	101	proteins	protein	NOUN
fnp-3806	1275	102	,	,	PUNCT
fnp-3806	1275	103	ai	ai	VERB
fnp-3806	1275	104	artificial	artificial	ADJ
fnp-3806	1275	105	intelligence	intelligence	NOUN
fnp-3806	1275	106	,	,	PUNCT
fnp-3806	1275	107	ales	ale	VERB
fnp-3806	1275	108	advanced	advanced	ADJ
fnp-3806	1275	109	lipoxidation	lipoxidation	NOUN
fnp-3806	1275	110	end	end	NOUN
fnp-3806	1275	111	-	-	PUNCT
fnp-3806	1275	112	products	product	NOUN
fnp-3806	1275	113	,	,	PUNCT
fnp-3806	1275	114	amp	amp	NOUN
fnp-3806	1275	115	adenosine	adenosine	NOUN
fnp-3806	1275	116	monophosphate	monophosphate	NOUN
fnp-3806	1275	117	,	,	PUNCT
fnp-3806	1275	118	ampa	ampa	PROPN
fnp-3806	1275	119	α	α	PROPN
fnp-3806	1275	120	-	-	PUNCT
fnp-3806	1275	121	amino-3	amino-3	PROPN
fnp-3806	1275	122	-	-	PUNCT
fnp-3806	1275	123	hydroxy-5	hydroxy-5	NUM
fnp-3806	1275	124	-	-	PUNCT
fnp-3806	1275	125	methyl-4	methyl-4	NOUN
fnp-3806	1275	126	-	-	PUNCT
fnp-3806	1275	127	isoxazolepropionic	isoxazolepropionic	NOUN
fnp-3806	1275	128	acid	acid	NOUN
fnp-3806	1275	129	,	,	PUNCT
fnp-3806	1275	130	ampar	ampar	ADP
fnp-3806	1275	131	α	α	PROPN
fnp-3806	1275	132	-	-	PUNCT
fnp-3806	1275	133	amino-3	amino-3	PROPN
fnp-3806	1275	134	-	-	PUNCT
fnp-3806	1275	135	hydroxy-5	hydroxy-5	NUM
fnp-3806	1275	136	-	-	PUNCT
fnp-3806	1275	137	methyl-4	methyl-4	NOUN
fnp-3806	1275	138	-	-	PUNCT
fnp-3806	1275	139	isoxazolepropionic	isoxazolepropionic	NOUN
fnp-3806	1275	140	acid	acid	NOUN
fnp-3806	1275	141	receptor	receptor	NOUN
fnp-3806	1275	142	,	,	PUNCT
fnp-3806	1275	143	aphh1a	aphh1a	PROPN
fnp-3806	1275	144	α	α	NOUN
fnp-3806	1275	145	-	-	PUNCT
fnp-3806	1275	146	secretase	secretase	NOUN
fnp-3806	1275	147	subunit	subunit	NOUN
fnp-3806	1275	148	a	a	PRON
fnp-3806	1275	149	,	,	PUNCT
fnp-3806	1275	150	apoe	apoe	ADJ
fnp-3806	1275	151	apolipoprotein	apolipoprotein	ADJ
fnp-3806	1275	152	e	e	PROPN
fnp-3806	1275	153	,	,	PUNCT
fnp-3806	1275	154	app	app	PROPN
fnp-3806	1275	155	amyloid	amyloid	NOUN
fnp-3806	1275	156	precursor	precursor	NOUN
fnp-3806	1275	157	protein	protein	NOUN
fnp-3806	1275	158	,	,	PUNCT
fnp-3806	1275	159	aqp	aqp	NOUN
fnp-3806	1275	160	aquaporin	aquaporin	NOUN
fnp-3806	1275	161	,	,	PUNCT
fnp-3806	1275	162	artag	artag	ADJ
fnp-3806	1275	163	aging	age	VERB
fnp-3806	1275	164	-	-	PUNCT
fnp-3806	1275	165	related	relate	VERB
fnp-3806	1275	166	tau	tau	PROPN
fnp-3806	1275	167	astrogliopathy	astrogliopathy	PROPN
fnp-3806	1275	168	,	,	PUNCT
fnp-3806	1275	169	asc	asc	PROPN
fnp-3806	1275	170	inflammasome	inflammasome	NOUN
fnp-3806	1275	171	-	-	PUNCT
fnp-3806	1275	172	adaptor	adaptor	NOUN
fnp-3806	1275	173	protein	protein	NOUN
fnp-3806	1275	174	,	,	PUNCT
fnp-3806	1275	175	atf-6	atf-6	PUNCT
fnp-3806	1275	176	activating	activate	VERB
fnp-3806	1275	177	transcription	transcription	NOUN
fnp-3806	1275	178	factor	factor	NOUN
fnp-3806	1275	179	6	6	NUM
fnp-3806	1275	180	,	,	PUNCT
fnp-3806	1275	181	atp8b1	atp8b1	PROPN
fnp-3806	1275	182	atpase	atpase	NOUN
fnp-3806	1275	183	phospholipid	phospholipid	NOUN
fnp-3806	1275	184	transporting	transport	VERB
fnp-3806	1275	185	8b1	8b1	NUM
fnp-3806	1275	186	,	,	PUNCT
fnp-3806	1275	187	atp	atp	NOUN
fnp-3806	1275	188	adenosine	adenosine	NOUN
fnp-3806	1275	189	triphosphate	triphosphate	NOUN
fnp-3806	1275	190	,	,	PUNCT
fnp-3806	1275	191	bace	bace	PROPN
fnp-3806	1275	192	β	β	NOUN
fnp-3806	1275	193	-	-	NOUN
fnp-3806	1275	194	secretase	secretase	NOUN
fnp-3806	1275	195	,	,	PUNCT
fnp-3806	1275	196	β	β	X
fnp-3806	1275	197	-	-	NOUN
fnp-3806	1275	198	ar	ar	VERB
fnp-3806	1275	199	β	β	NOUN
fnp-3806	1275	200	-	-	ADJ
fnp-3806	1275	201	adrenergic	adrenergic	ADJ
fnp-3806	1275	202	receptor	receptor	NOUN
fnp-3806	1275	203	,	,	PUNCT
fnp-3806	1275	204	bbb	bbb	NOUN
fnp-3806	1275	205	blood	blood	NOUN
fnp-3806	1275	206	brain	brain	NOUN
fnp-3806	1275	207	barrier	barrier	NOUN
fnp-3806	1275	208	,	,	PUNCT
fnp-3806	1275	209	bdnf	bdnf	ADJ
fnp-3806	1275	210	brain	brain	NOUN
fnp-3806	1275	211	-	-	PUNCT
fnp-3806	1275	212	derived	derive	VERB
fnp-3806	1275	213	neurotrophic	neurotrophic	ADJ
fnp-3806	1275	214	factor	factor	NOUN
fnp-3806	1275	215	,	,	PUNCT
fnp-3806	1275	216	bin1	bin1	NOUN
fnp-3806	1275	217	bridging	bridge	VERB
fnp-3806	1275	218	integrator	integrator	NOUN
fnp-3806	1275	219	1	1	NUM
fnp-3806	1275	220	,	,	PUNCT
fnp-3806	1275	221	c1qtnf7	c1qtnf7	NOUN
fnp-3806	1275	222	complement	complement	VERB
fnp-3806	1275	223	c1q	c1q	ADP
fnp-3806	1275	224	tumor	tumor	NOUN
fnp-3806	1275	225	necrosis	necrosis	NOUN
fnp-3806	1275	226	factor	factor	NOUN
fnp-3806	1275	227	-	-	PUNCT
fnp-3806	1275	228	related	relate	VERB
fnp-3806	1275	229	protein	protein	NOUN
fnp-3806	1275	230	7	7	NUM
fnp-3806	1275	231	,	,	PUNCT
fnp-3806	1275	232	c3ar1	c3ar1	VERB
fnp-3806	1275	233	complement	complement	NOUN
fnp-3806	1275	234	c3a	c3a	PROPN
fnp-3806	1275	235	receptor	receptor	NOUN
fnp-3806	1275	236	1	1	NUM
fnp-3806	1275	237	,	,	PUNCT
fnp-3806	1275	238	ca2	ca2	PROPN
fnp-3806	1275	239	+	+	PROPN
fnp-3806	1275	240	calcium	calcium	NOUN
fnp-3806	1275	241	ion	ion	NOUN
fnp-3806	1275	242	,	,	PUNCT
fnp-3806	1275	243	camp	camp	NOUN
fnp-3806	1275	244	cyclic	cyclic	ADJ
fnp-3806	1275	245	adenosine	adenosine	NOUN
fnp-3806	1275	246	monophosphate	monophosphate	NOUN
fnp-3806	1275	247	,	,	PUNCT
fnp-3806	1275	248	cb	cb	PROPN
fnp-3806	1275	249	calbindin	calbindin	PROPN
fnp-3806	1275	250	d28k	d28k	PROPN
fnp-3806	1275	251	,	,	PUNCT
fnp-3806	1275	252	cbf	cbf	PROPN
fnp-3806	1275	253	cerebral	cerebral	ADJ
fnp-3806	1275	254	blood	blood	NOUN
fnp-3806	1275	255	flow	flow	NOUN
fnp-3806	1275	256	,	,	PUNCT
fnp-3806	1275	257	cbr	cbr	PROPN
fnp-3806	1275	258	cannabinoid	cannabinoid	NOUN
fnp-3806	1275	259	receptor	receptor	NOUN
fnp-3806	1275	260	,	,	PUNCT
fnp-3806	1275	261	cd2ap	cd2ap	NOUN
fnp-3806	1275	262	cd2	cd2	PROPN
fnp-3806	1275	263	-	-	PUNCT
fnp-3806	1275	264	associated	associate	VERB
fnp-3806	1275	265	protein	protein	NOUN
fnp-3806	1275	266	,	,	PUNCT
fnp-3806	1275	267	cdk5	cdk5	PROPN
fnp-3806	1275	268	cyclin	cyclin	PROPN
fnp-3806	1275	269	-	-	PUNCT
fnp-3806	1275	270	dependent	dependent	ADJ
fnp-3806	1275	271	kinase	kinase	NOUN
fnp-3806	1275	272	5	5	NUM
fnp-3806	1275	273	,	,	PUNCT
fnp-3806	1275	274	cerad	cerad	PROPN
fnp-3806	1275	275	consortium	consortium	NOUN
fnp-3806	1275	276	to	to	PART
fnp-3806	1275	277	establish	establish	VERB
fnp-3806	1275	278	a	a	DET
fnp-3806	1275	279	registry	registry	NOUN
fnp-3806	1275	280	for	for	ADP
fnp-3806	1275	281	alzheimer	alzheimer	PROPN
fnp-3806	1275	282	’s	’s	PART
fnp-3806	1275	283	disease	disease	NOUN
fnp-3806	1275	284	,	,	PUNCT
fnp-3806	1275	285	cel	cel	PROPN
fnp-3806	1275	286	carboxyethyl	carboxyethyl	PROPN
fnp-3806	1275	287	-	-	PUNCT
fnp-3806	1275	288	lysine	lysine	NOUN
fnp-3806	1275	289	,	,	PUNCT
fnp-3806	1275	290	cgmp	cgmp	PROPN
fnp-3806	1275	291	cyclic	cyclic	PROPN
fnp-3806	1275	292	guanosine	guanosine	PROPN
fnp-3806	1275	293	monophosphate	monophosphate	NOUN
fnp-3806	1275	294	,	,	PUNCT
fnp-3806	1275	295	chat	chat	VERB
fnp-3806	1275	296	choline	choline	NOUN
fnp-3806	1275	297	acetyl	acetyl	NOUN
fnp-3806	1275	298	transferase	transferase	NOUN
fnp-3806	1275	299	,	,	PUNCT
fnp-3806	1275	300	ck1	ck1	PROPN
fnp-3806	1275	301	-	-	PUNCT
fnp-3806	1275	302	δ	δ	PROPN
fnp-3806	1275	303	casein	casein	PROPN
fnp-3806	1275	304	kinase	kinase	PROPN
fnp-3806	1276	1	i	i	PRON
fnp-3806	1276	2	isoform	isoform	VERB
fnp-3806	1276	3	delta	delta	PROPN
fnp-3806	1276	4	,	,	PUNCT
fnp-3806	1276	5	clu	clu	PROPN
fnp-3806	1276	6	clusterin	clusterin	PROPN
fnp-3806	1276	7	,	,	PUNCT
fnp-3806	1276	8	cml	cml	PROPN
fnp-3806	1276	9	carboxymethyl	carboxymethyl	NOUN
fnp-3806	1276	10	-	-	PUNCT
fnp-3806	1276	11	lysine	lysine	NOUN
fnp-3806	1276	12	,	,	PUNCT
fnp-3806	1276	13	cmv	cmv	PROPN
fnp-3806	1276	14	human	human	ADJ
fnp-3806	1276	15	cytomegalovirus	cytomegalovirus	NOUN
fnp-3806	1276	16	,	,	PUNCT
fnp-3806	1276	17	cnp	cnp	PROPN
fnp-3806	1276	18	2',3'-cyclic	2',3'-cyclic	NUM
fnp-3806	1276	19	-	-	PUNCT
fnp-3806	1276	20	nucleotide	nucleotide	NOUN
fnp-3806	1276	21	3'-phosphodiesterase	3'-phosphodiesterase	NUM
fnp-3806	1276	22	,	,	PUNCT
fnp-3806	1276	23	cns	cns	PROPN
fnp-3806	1276	24	central	central	ADJ
fnp-3806	1276	25	nervous	nervous	ADJ
fnp-3806	1276	26	system	system	NOUN
fnp-3806	1276	27	,	,	PUNCT
fnp-3806	1276	28	comt	comt	PROPN
fnp-3806	1276	29	catechol	catechol	NOUN
fnp-3806	1276	30	-	-	PUNCT
fnp-3806	1276	31	o	o	NOUN
fnp-3806	1276	32	-	-	NOUN
fnp-3806	1276	33	methyltransferase	methyltransferase	NOUN
fnp-3806	1276	34	,	,	PUNCT
fnp-3806	1276	35	cpg	cpg	NOUN
fnp-3806	1276	36	cytosine	cytosine	NOUN
fnp-3806	1276	37	-	-	PUNCT
fnp-3806	1276	38	guanine	guanine	NOUN
fnp-3806	1276	39	-	-	PUNCT
fnp-3806	1276	40	rich	rich	ADJ
fnp-3806	1276	41	regions	region	NOUN
fnp-3806	1276	42	,	,	PUNCT
fnp-3806	1276	43	cr	cr	PROPN
fnp-3806	1276	44	calretinin	calretinin	PROPN
fnp-3806	1276	45	,	,	PUNCT
fnp-3806	1276	46	cr1	cr1	PROPN
fnp-3806	1276	47	complement	complement	NOUN
fnp-3806	1276	48	component	component	NOUN
fnp-3806	1276	49	(	(	PUNCT
fnp-3806	1276	50	3b/4b	3b/4b	NUM
fnp-3806	1276	51	)	)	PUNCT
fnp-3806	1276	52	receptor	receptor	NOUN
fnp-3806	1276	53	1	1	NUM
fnp-3806	1276	54	,	,	PUNCT
fnp-3806	1276	55	creb	creb	NOUN
fnp-3806	1276	56	camp	camp	NOUN
fnp-3806	1276	57	response	response	NOUN
fnp-3806	1276	58	element	element	NOUN
fnp-3806	1276	59	-	-	PUNCT
fnp-3806	1276	60	binding	bind	VERB
fnp-3806	1276	61	protein	protein	NOUN
fnp-3806	1276	62	,	,	PUNCT
fnp-3806	1276	63	csf	csf	ADJ
fnp-3806	1276	64	cerebrospinal	cerebrospinal	ADJ
fnp-3806	1276	65	fluid	fluid	NOUN
fnp-3806	1276	66	,	,	PUNCT
fnp-3806	1277	1	csf1r	csf1r	X
fnp-3806	1277	2	colony	colony	NOUN
fnp-3806	1277	3	stimulating	stimulate	VERB
fnp-3806	1277	4	factor	factor	NOUN
fnp-3806	1277	5	1	1	NUM
fnp-3806	1277	6	receptor	receptor	NOUN
fnp-3806	1277	7	,	,	PUNCT
fnp-3806	1277	8	csf3r	csf3r	NOUN
fnp-3806	1277	9	colony	colony	NOUN
fnp-3806	1277	10	stimulating	stimulate	VERB
fnp-3806	1277	11	factor	factor	NOUN
fnp-3806	1277	12	3	3	NUM
fnp-3806	1277	13	receptor	receptor	NOUN
fnp-3806	1277	14	,	,	PUNCT
fnp-3806	1277	15	ct	ct	PROPN
fnp-3806	1277	16	computed	compute	VERB
fnp-3806	1277	17	tomography	tomography	NOUN
fnp-3806	1277	18	,	,	PUNCT
fnp-3806	1277	19	dag	dag	PROPN
fnp-3806	1277	20	diacylglycerol	diacylglycerol	NOUN
fnp-3806	1277	21	,	,	PUNCT
fnp-3806	1277	22	dbh	dbh	PROPN
fnp-3806	1277	23	dopamine	dopamine	NOUN
fnp-3806	1277	24	β	β	NOUN
fnp-3806	1277	25	-	-	NOUN
fnp-3806	1277	26	hydroxylase	hydroxylase	ADJ
fnp-3806	1277	27	,	,	PUNCT
fnp-3806	1277	28	dcx	dcx	PROPN
fnp-3806	1277	29	doublecortin	doublecortin	PROPN
fnp-3806	1277	30	,	,	PUNCT
fnp-3806	1277	31	dha	dha	PROPN
fnp-3806	1277	32	docosahexanoic	docosahexanoic	PROPN
fnp-3806	1277	33	acid	acid	PROPN
fnp-3806	1277	34	,	,	PUNCT
fnp-3806	1277	35	dnmt	dnmt	NOUN
fnp-3806	1277	36	dna	dna	PROPN
fnp-3806	1277	37	methyl	methyl	NOUN
fnp-3806	1277	38	transferases	transferase	NOUN
fnp-3806	1277	39	,	,	PUNCT
fnp-3806	1277	40	gsh	gsh	NOUN
fnp-3806	1277	41	glutathione	glutathione	NOUN
fnp-3806	1277	42	,	,	PUNCT
fnp-3806	1277	43	eaat	eaat	ADJ
fnp-3806	1277	44	excitatory	excitatory	ADJ
fnp-3806	1277	45	amino	amino	NOUN
fnp-3806	1277	46	acid	acid	NOUN
fnp-3806	1277	47	transporter	transporter	NOUN
fnp-3806	1277	48	,	,	PUNCT
fnp-3806	1277	49	ebv	ebv	PROPN
fnp-3806	1277	50	epstein	epstein	PROPN
fnp-3806	1277	51	-	-	PUNCT
fnp-3806	1277	52	barr	barr	PROPN
fnp-3806	1277	53	virus	virus	PROPN
fnp-3806	1277	54	,	,	PUNCT
fnp-3806	1277	55	eofad	eofad	VERB
fnp-3806	1277	56	early	early	ADJ
fnp-3806	1277	57	onset	onset	VERB
fnp-3806	1277	58	alzheimer	alzheimer	NOUN
fnp-3806	1277	59	disease	disease	PROPN
fnp-3806	1277	60	,	,	PUNCT
fnp-3806	1277	61	eph	eph	PROPN
fnp-3806	1277	62	ephrin	ephrin	PROPN
fnp-3806	1277	63	,	,	PUNCT
fnp-3806	1277	64	epha1	epha1	ADJ
fnp-3806	1277	65	ephrin	ephrin	ADJ
fnp-3806	1277	66	receptor	receptor	NOUN
fnp-3806	1277	67	a1	a1	NOUN
fnp-3806	1277	68	,	,	PUNCT
fnp-3806	1277	69	er	er	INTJ
fnp-3806	1277	70	endoplasmic	endoplasmic	ADJ
fnp-3806	1277	71	reticulum	reticulum	NOUN
fnp-3806	1277	72	,	,	PUNCT
fnp-3806	1277	73	exrnas	exrna	NOUN
fnp-3806	1277	74	extracellular	extracellular	ADJ
fnp-3806	1277	75	rnas	rna	NOUN
fnp-3806	1277	76	,	,	PUNCT
fnp-3806	1277	77	fad	fad	ADJ
fnp-3806	1277	78	familial	familial	ADJ
fnp-3806	1277	79	alzheimer	alzheimer	NOUN
fnp-3806	1277	80	disease	disease	NOUN
fnp-3806	1277	81	,	,	PUNCT
fnp-3806	1277	82	fad	fad	X
fnp-3806	1277	83	flavin	flavin	NOUN
fnp-3806	1277	84	adenine	adenine	ADJ
fnp-3806	1277	85	dinucleotide	dinucleotide	NOUN
fnp-3806	1277	86	,	,	PUNCT
fnp-3806	1277	87	fbd	fbd	PROPN
fnp-3806	1277	88	familial	familial	ADJ
fnp-3806	1277	89	british	british	ADJ
fnp-3806	1277	90	dementia	dementia	NOUN
fnp-3806	1277	91	,	,	PUNCT
fnp-3806	1277	92	fcγriib	fcγriib	NOUN
fnp-3806	1277	93	fcγ	fcγ	NOUN
fnp-3806	1277	94	,	,	PUNCT
fnp-3806	1277	95	receptor	receptor	NOUN
fnp-3806	1277	96	ii	ii	PROPN
fnp-3806	1277	97	-	-	PUNCT
fnp-3806	1277	98	b	b	PROPN
fnp-3806	1277	99	,	,	PUNCT
fnp-3806	1277	100	fdd	fdd	PROPN
fnp-3806	1277	101	familial	familial	ADJ
fnp-3806	1277	102	danish	danish	ADJ
fnp-3806	1277	103	dementia	dementia	PROPN
fnp-3806	1277	104	,	,	PUNCT
fnp-3806	1277	105	gaba	gaba	PROPN
fnp-3806	1277	106	γaminobutyric	γaminobutyric	PROPN
fnp-3806	1277	107	acid	acid	PROPN
fnp-3806	1277	108	,	,	PUNCT
fnp-3806	1277	109	gabaa	gabaa	NOUN
fnp-3806	1277	110	receptors	receptor	NOUN
fnp-3806	1277	111	ionotropic	ionotropic	ADJ
fnp-3806	1277	112	gabaa	gabaa	NOUN
fnp-3806	1277	113	receptors	receptor	NOUN
fnp-3806	1277	114	,	,	PUNCT
fnp-3806	1277	115	gabab	gabab	NOUN
fnp-3806	1277	116	receptors	receptor	NOUN
fnp-3806	1277	117	metabotropic	metabotropic	NOUN
fnp-3806	1277	118	gabab	gabab	NOUN
fnp-3806	1277	119	receptors	receptor	NOUN
fnp-3806	1277	120	,	,	PUNCT
fnp-3806	1277	121	gad	gad	PROPN
fnp-3806	1277	122	glutamic	glutamic	ADJ
fnp-3806	1277	123	acid	acid	PROPN
fnp-3806	1277	124	decarboxylase	decarboxylase	PROPN
fnp-3806	1277	125	,	,	PUNCT
fnp-3806	1277	126	gap-43	gap-43	VERB
fnp-3806	1277	127	growth	growth	NOUN
fnp-3806	1277	128	-	-	PUNCT
fnp-3806	1277	129	associated	associate	VERB
fnp-3806	1277	130	protein	protein	NOUN
fnp-3806	1277	131	43	43	NUM
fnp-3806	1277	132	,	,	PUNCT
fnp-3806	1277	133	gdh	gdh	ADJ
fnp-3806	1277	134	glutamate	glutamate	ADJ
fnp-3806	1277	135	dehydrogenase	dehydrogenase	NOUN
fnp-3806	1277	136	,	,	PUNCT
fnp-3806	1277	137	gfap	gfap	ADJ
fnp-3806	1277	138	glial	glial	ADJ
fnp-3806	1277	139	fibrillary	fibrillary	ADJ
fnp-3806	1277	140	acidic	acidic	ADJ
fnp-3806	1277	141	protein	protein	NOUN
fnp-3806	1277	142	,	,	PUNCT
fnp-3806	1277	143	glurs	glur	VERB
fnp-3806	1277	144	glutamate	glutamate	ADJ
fnp-3806	1277	145	receptors	receptor	NOUN
fnp-3806	1277	146	,	,	PUNCT
fnp-3806	1277	147	glut	glut	VERB
fnp-3806	1277	148	1	1	NUM
fnp-3806	1277	149	glucose	glucose	NOUN
fnp-3806	1277	150	transporter	transporter	NOUN
fnp-3806	1277	151	1	1	NUM
fnp-3806	1277	152	,	,	PUNCT
fnp-3806	1277	153	gmp	gmp	PROPN
fnp-3806	1277	154	guanosine	guanosine	PROPN
fnp-3806	1277	155	monophosphate	monophosphate	PROPN
fnp-3806	1277	156	,	,	PUNCT
fnp-3806	1277	157	gpcr	gpcr	ADJ
fnp-3806	1277	158	g	g	NOUN
fnp-3806	1277	159	-	-	PUNCT
fnp-3806	1277	160	protein	protein	NOUN
fnp-3806	1277	161	-	-	PUNCT
fnp-3806	1277	162	coupled	couple	VERB
fnp-3806	1277	163	receptor	receptor	NOUN
fnp-3806	1277	164	,	,	PUNCT
fnp-3806	1277	165	grp78	grp78	PROPN
fnp-3806	1277	166	/	/	SYM
fnp-3806	1277	167	bip	bip	PROPN
fnp-3806	1277	168	glucose	glucose	NOUN
fnp-3806	1277	169	-	-	PUNCT
fnp-3806	1277	170	related	relate	VERB
fnp-3806	1277	171	protein	protein	NOUN
fnp-3806	1277	172	78	78	NUM
fnp-3806	1277	173	,	,	PUNCT
fnp-3806	1277	174	gsk3β	gsk3β	PROPN
fnp-3806	1277	175	glycogen	glycogen	NOUN
fnp-3806	1277	176	synthase	synthase	NOUN
fnp-3806	1277	177	kinase	kinase	PROPN
fnp-3806	1277	178	3β	3β	PROPN
fnp-3806	1277	179	,	,	PUNCT
fnp-3806	1277	180	gss	gss	ADJ
fnp-3806	1277	181	gerstmann	gerstmann	NOUN
fnp-3806	1277	182	-	-	PUNCT
fnp-3806	1277	183	sträussler	sträussler	NOUN
fnp-3806	1277	184	-	-	PUNCT
fnp-3806	1277	185	scheinker	scheinker	NOUN
fnp-3806	1277	186	,	,	PUNCT
fnp-3806	1277	187	gvd	gvd	VERB
fnp-3806	1277	188	granulovacuolar	granulovacuolar	ADJ
fnp-3806	1277	189	degeneration	degeneration	NOUN
fnp-3806	1277	190	,	,	PUNCT
fnp-3806	1277	191	gwas	gwas	NOUN
fnp-3806	1277	192	genome	genome	NOUN
fnp-3806	1277	193	-	-	PUNCT
fnp-3806	1277	194	wide	wide	ADJ
fnp-3806	1277	195	association	association	NOUN
fnp-3806	1277	196	studies	study	NOUN
fnp-3806	1277	197	,	,	PUNCT
fnp-3806	1277	198	h3k4me1	h3k4me1	PROPN
fnp-3806	1277	199	methylation	methylation	NOUN
fnp-3806	1277	200	of	of	ADP
fnp-3806	1277	201	lysine	lysine	NOUN
fnp-3806	1277	202	4	4	NUM
fnp-3806	1277	203	of	of	ADP
fnp-3806	1277	204	histone	histone	NOUN
fnp-3806	1277	205	3	3	NUM
fnp-3806	1277	206	,	,	PUNCT
fnp-3806	1277	207	h3k4m3	h3k4m3	NOUN
fnp-3806	1277	208	trimethylation	trimethylation	NOUN
fnp-3806	1277	209	of	of	ADP
fnp-3806	1277	210	histone	histone	NOUN
fnp-3806	1277	211	3	3	NUM
fnp-3806	1277	212	at	at	ADP
fnp-3806	1277	213	lysine	lysine	NOUN
fnp-3806	1277	214	4	4	NUM
fnp-3806	1277	215	,	,	PUNCT
fnp-3806	1277	216	h3k9me2	h3k9me2	ADJ
fnp-3806	1277	217	dimethylation	dimethylation	NOUN
fnp-3806	1277	218	of	of	ADP
fnp-3806	1277	219	histone	histone	NOUN
fnp-3806	1277	220	h3	h3	NOUN
fnp-3806	1277	221	at	at	ADP
fnp-3806	1277	222	lysine	lysine	NOUN
fnp-3806	1277	223	9	9	NUM
fnp-3806	1277	224	,	,	PUNCT
fnp-3806	1277	225	hat	hat	NOUN
fnp-3806	1277	226	histone	histone	NOUN
fnp-3806	1277	227	acetyltransferase	acetyltransferase	PROPN
fnp-3806	1277	228	,	,	PUNCT
fnp-3806	1277	229	hdac	hdac	PROPN
fnp-3806	1277	230	histone	histone	PROPN
fnp-3806	1277	231	deacetylase	deacetylase	PROPN
fnp-3806	1277	232	,	,	PUNCT
fnp-3806	1277	233	hdm	hdm	PROPN
fnp-3806	1277	234	histone	histone	PROPN
fnp-3806	1277	235	demethylase	demethylase	PROPN
fnp-3806	1277	236	,	,	PUNCT
fnp-3806	1277	237	hhv-6	hhv-6	ADJ
fnp-3806	1277	238	human	human	ADJ
fnp-3806	1277	239	herpes	herpe	NOUN
fnp-3806	1277	240	virus	virus	NOUN
fnp-3806	1277	241	6	6	NUM
fnp-3806	1277	242	,	,	PUNCT
fnp-3806	1277	243	hmt	hmt	NOUN
fnp-3806	1277	244	histone	histone	NOUN
fnp-3806	1277	245	methyltransferase	methyltransferase	NOUN
fnp-3806	1277	246	,	,	PUNCT
fnp-3806	1277	247	hne	hne	NOUN
fnp-3806	1277	248	4	4	NOUN
fnp-3806	1277	249	-	-	PUNCT
fnp-3806	1277	250	hydroxynonenal	hydroxynonenal	NOUN
fnp-3806	1277	251	,	,	PUNCT
fnp-3806	1277	252	hsv-1	hsv-1	NOUN
fnp-3806	1277	253	herpes	herpe	NOUN
fnp-3806	1277	254	simplex	simplex	NOUN
fnp-3806	1277	255	virus	virus	NOUN
fnp-3806	1277	256	1	1	NUM
fnp-3806	1277	257	,	,	PUNCT
fnp-3806	1277	258	icjd	icjd	VERB
fnp-3806	1277	259	iatrogenic	iatrogenic	ADJ
fnp-3806	1277	260	creutzfeldt	creutzfeldt	ADJ
fnp-3806	1277	261	-	-	ADJ
fnp-3806	1277	262	jabob	jabob	ADJ
fnp-3806	1277	263	disease	disease	NOUN
fnp-3806	1277	264	,	,	PUNCT
fnp-3806	1277	265	ide	ide	ADJ
fnp-3806	1277	266	insulin	insulin	NOUN
fnp-3806	1277	267	degrading	degrade	VERB
fnp-3806	1277	268	enzyme	enzyme	NOUN
fnp-3806	1277	269	,	,	PUNCT
fnp-3806	1277	270	ifn	ifn	PROPN
fnp-3806	1277	271	-	-	PUNCT
fnp-3806	1277	272	γ	γ	X
fnp-3806	1277	273	interferon	interferon	PROPN
fnp-3806	1277	274	γ	γ	PROPN
fnp-3806	1277	275	,	,	PUNCT
fnp-3806	1277	276	iglur	iglur	ADJ
fnp-3806	1277	277	ioinotropic	ioinotropic	ADJ
fnp-3806	1277	278	glutamate	glutamate	NOUN
fnp-3806	1277	279	receptor	receptor	NOUN
fnp-3806	1277	280	,	,	PUNCT
fnp-3806	1277	281	il	il	PROPN
fnp-3806	1277	282	interleukin	interleukin	PROPN
fnp-3806	1277	283	,	,	PUNCT
fnp-3806	1277	284	ipsc	ipsc	PROPN
fnp-3806	1277	285	indiuced	indiuce	VERB
fnp-3806	1277	286	pluripotent	pluripotent	ADJ
fnp-3806	1277	287	stem	stem	NOUN
fnp-3806	1277	288	cells	cell	NOUN
fnp-3806	1277	289	,	,	PUNCT
fnp-3806	1277	290	ire	ire	VERB
fnp-3806	1277	291	1	1	NUM
fnp-3806	1277	292	inositol	inositol	NOUN
fnp-3806	1277	293	-	-	PUNCT
fnp-3806	1277	294	requiring	require	VERB
fnp-3806	1277	295	protein	protein	NOUN
fnp-3806	1277	296	1	1	NUM
fnp-3806	1277	297	,	,	PUNCT
fnp-3806	1277	298	jak2	jak2	PROPN
fnp-3806	1277	299	janus	janus	PROPN
fnp-3806	1277	300	kinase	kinase	PROPN
fnp-3806	1277	301	2	2	NUM
fnp-3806	1277	302	,	,	PUNCT
fnp-3806	1277	303	ka	ka	PROPN
fnp-3806	1277	304	kainate	kainate	PROPN
fnp-3806	1277	305	,	,	PUNCT
fnp-3806	1277	306	kar	kar	PROPN
fnp-3806	1277	307	kainate	kainate	NOUN
fnp-3806	1277	308	receptor	receptor	NOUN
fnp-3806	1277	309	,	,	PUNCT
fnp-3806	1277	310	lamp-1	lamp-1	NUM
fnp-3806	1277	311	lysosomal	lysosomal	NOUN
fnp-3806	1277	312	-	-	PUNCT
fnp-3806	1277	313	associated	associate	VERB
fnp-3806	1277	314	membrane	membrane	NOUN
fnp-3806	1277	315	protein	protein	NOUN
fnp-3806	1277	316	1	1	NUM
fnp-3806	1277	317	,	,	PUNCT
fnp-3806	1278	1	lc3	lc3	NOUN
fnp-3806	1278	2	protein	protein	NOUN
fnp-3806	1278	3	light	light	NOUN
fnp-3806	1278	4	chain	chain	NOUN
fnp-3806	1278	5	3	3	NUM
fnp-3806	1278	6	,	,	PUNCT
fnp-3806	1278	7	lc	lc	PROPN
fnp-3806	1278	8	-	-	PUNCT
fnp-3806	1278	9	ms	ms	PROPN
fnp-3806	1278	10	/	/	SYM
fnp-3806	1278	11	ms	ms	NOUN
fnp-3806	1278	12	liquid	liquid	ADJ
fnp-3806	1278	13	chromatography	chromatography	NOUN
fnp-3806	1278	14	(	(	PUNCT
fnp-3806	1278	15	lc	lc	PROPN
fnp-3806	1278	16	)	)	PUNCT
fnp-3806	1278	17	tandem	tandem	PROPN
fnp-3806	1278	18	mass	mass	ADJ
fnp-3806	1278	19	spectrometry	spectrometry	NOUN
fnp-3806	1278	20	(	(	PUNCT
fnp-3806	1278	21	ms	ms	PROPN
fnp-3806	1278	22	)	)	PUNCT
fnp-3806	1278	23	,	,	PUNCT
fnp-3806	1278	24	lcnrnas	lcnrnas	PROPN
fnp-3806	1278	25	long	long	ADJ
fnp-3806	1278	26	non	non	ADJ
fnp-3806	1278	27	-	-	ADJ
fnp-3806	1278	28	coding	coding	ADJ
fnp-3806	1278	29	rnas	rna	NOUN
fnp-3806	1278	30	,	,	PUNCT
fnp-3806	1278	31	ldh	ldh	PROPN
fnp-3806	1278	32	lactate	lactate	PROPN
fnp-3806	1278	33	dehydrogenase	dehydrogenase	NOUN
fnp-3806	1278	34	,	,	PUNCT
fnp-3806	1278	35	ldlr	ldlr	ADJ
fnp-3806	1278	36	low	low	ADJ
fnp-3806	1278	37	density	density	NOUN
fnp-3806	1278	38	lipoprotein	lipoprotein	ADJ
fnp-3806	1278	39	protein	protein	NOUN
fnp-3806	1278	40	receptor	receptor	NOUN
fnp-3806	1278	41	1	1	NUM
fnp-3806	1278	42	,	,	PUNCT
fnp-3806	1278	43	lilrb2	lilrb2	NOUN
fnp-3806	1278	44	pirb	pirb	VERB
fnp-3806	1278	45	human	human	ADJ
fnp-3806	1278	46	orthologue	orthologue	NOUN
fnp-3806	1278	47	receptor	receptor	NOUN
fnp-3806	1278	48	,	,	PUNCT
fnp-3806	1278	49	load	load	VERB
fnp-3806	1278	50	late	late	ADJ
fnp-3806	1278	51	onset	onset	ADJ
fnp-3806	1278	52	alzheimer	alzheimer	PROPN
fnp-3806	1278	53	disease	disease	PROPN
fnp-3806	1278	54	,	,	PUNCT
fnp-3806	1278	55	lp2	lp2	PROPN
fnp-3806	1278	56	lipoprotein	lipoprotein	ADJ
fnp-3806	1278	57	lipase	lipase	NOUN
fnp-3806	1278	58	2	2	NUM
fnp-3806	1278	59	,	,	PUNCT
fnp-3806	1278	60	lrp1	lrp1	PROPN
fnp-3806	1278	61	hldl	hldl	NOUN
fnp-3806	1278	62	receptor	receptor	NOUN
fnp-3806	1278	63	related	relate	VERB
fnp-3806	1278	64	protein	protein	NOUN
fnp-3806	1278	65	1	1	NUM
fnp-3806	1278	66	,	,	PUNCT
fnp-3806	1278	67	ma	ma	PROPN
fnp-3806	1278	68	middle	middle	PROPN
fnp-3806	1278	69	-	-	PUNCT
fnp-3806	1278	70	aged	aged	ADJ
fnp-3806	1278	71	,	,	PUNCT
fnp-3806	1278	72	machr	machr	ADJ
fnp-3806	1278	73	muscarinic	muscarinic	ADJ
fnp-3806	1278	74	acetylcholine	acetylcholine	NOUN
fnp-3806	1278	75	receptor	receptor	NOUN
fnp-3806	1278	76	,	,	PUNCT
fnp-3806	1278	77	mag	mag	ADJ
fnp-3806	1278	78	myelin	myelin	NOUN
fnp-3806	1278	79	associated	associate	VERB
fnp-3806	1278	80	glycoprotein	glycoprotein	NOUN
fnp-3806	1278	81	,	,	PUNCT
fnp-3806	1278	82	mal	mal	ADJ
fnp-3806	1278	83	myelkin	myelkin	NOUN
fnp-3806	1278	84	and	and	CCONJ
fnp-3806	1278	85	lymphocyte	lymphocyte	ADJ
fnp-3806	1278	86	protein	protein	NOUN
fnp-3806	1278	87	,	,	PUNCT
fnp-3806	1278	88	mams	mams	PROPN
fnp-3806	1278	89	mitochondria	mitochondria	PROPN
fnp-3806	1278	90	-	-	PUNCT
fnp-3806	1278	91	associated	associate	VERB
fnp-3806	1278	92	er	er	INTJ
fnp-3806	1278	93	membranes	membrane	NOUN
fnp-3806	1278	94	,	,	PUNCT
fnp-3806	1278	95	map2	map2	NOUN
fnp-3806	1278	96	microtubule	microtubule	NOUN
fnp-3806	1278	97	associated	associate	VERB
fnp-3806	1278	98	protein	protein	NOUN
fnp-3806	1278	99	2	2	NUM
fnp-3806	1278	100	,	,	PUNCT
fnp-3806	1278	101	mapk	mapk	NOUN
fnp-3806	1278	102	mitogen	mitogen	NOUN
fnp-3806	1278	103	-	-	PUNCT
fnp-3806	1278	104	activated	activate	VERB
fnp-3806	1278	105	protein	protein	NOUN
fnp-3806	1278	106	kinase	kinase	NOUN
fnp-3806	1278	107	,	,	PUNCT
fnp-3806	1278	108	mapt	mapt	NOUN
fnp-3806	1278	109	microtubule	microtubule	NOUN
fnp-3806	1278	110	associated	associate	VERB
fnp-3806	1278	111	protein	protein	NOUN
fnp-3806	1278	112	tau	tau	NOUN
fnp-3806	1278	113	,	,	PUNCT
fnp-3806	1278	114	mapt	mapt	VERB
fnp-3806	1278	115	h1	h1	PROPN
fnp-3806	1278	116	microtubule	microtubule	NOUN
fnp-3806	1278	117	-	-	PUNCT
fnp-3806	1278	118	associated	associate	VERB
fnp-3806	1278	119	protein	protein	NOUN
fnp-3806	1278	120	tau	tau	PROPN
fnp-3806	1278	121	haplotype	haplotype	NOUN
fnp-3806	1278	122	1	1	NUM
fnp-3806	1278	123	,	,	PUNCT
fnp-3806	1278	124	mao	mao	NOUN
fnp-3806	1278	125	mono	mono	NOUN
fnp-3806	1278	126	-	-	PUNCT
fnp-3806	1278	127	amino	amino	NOUN
fnp-3806	1278	128	oxidase	oxidase	NOUN
fnp-3806	1278	129	,	,	PUNCT
fnp-3806	1278	130	mbp	mbp	X
fnp-3806	1278	131	myelin	myelin	ADJ
fnp-3806	1278	132	basic	basic	ADJ
fnp-3806	1278	133	protein	protein	NOUN
fnp-3806	1278	134	,	,	PUNCT
fnp-3806	1278	135	mci	mci	NOUN
fnp-3806	1278	136	mild	mild	ADJ
fnp-3806	1278	137	cognitive	cognitive	ADJ
fnp-3806	1278	138	impairment	impairment	NOUN
fnp-3806	1278	139	,	,	PUNCT
fnp-3806	1278	140	mda	mda	PROPN
fnp-3806	1278	141	malondialdehyde	malondialdehyde	PROPN
fnp-3806	1278	142	,	,	PUNCT
fnp-3806	1278	143	mdal	mdal	NOUN
fnp-3806	1278	144	mda	mda	PROPN
fnp-3806	1278	145	-	-	PUNCT
fnp-3806	1278	146	lysine	lysine	NOUN
fnp-3806	1278	147	,	,	PUNCT
fnp-3806	1278	148	mef2c	mef2c	PROPN
fnp-3806	1278	149	myocyte	myocyte	NOUN
fnp-3806	1278	150	-	-	PUNCT
fnp-3806	1278	151	specific	specific	ADJ
fnp-3806	1278	152	enhancer	enhancer	NOUN
fnp-3806	1278	153	factor	factor	NOUN
fnp-3806	1278	154	2c	2c	NOUN
fnp-3806	1278	155	,	,	PUNCT
fnp-3806	1278	156	mg2	mg2	PROPN
fnp-3806	1278	157	+	+	PROPN
fnp-3806	1278	158	magnesium	magnesium	NOUN
fnp-3806	1278	159	ion	ion	NOUN
fnp-3806	1278	160	,	,	PUNCT
fnp-3806	1278	161	mglur	mglur	PROPN
fnp-3806	1278	162	metabotropic	metabotropic	NOUN
fnp-3806	1278	163	glutamate	glutamate	ADJ
fnp-3806	1278	164	receptor	receptor	NOUN
fnp-3806	1278	165	,	,	PUNCT
fnp-3806	1278	166	mirna	mirna	PROPN
fnp-3806	1278	167	microrna	microrna	PROPN
fnp-3806	1278	168	,	,	PUNCT
fnp-3806	1278	169	mlkl	mlkl	VERB
fnp-3806	1278	170	mixed	mixed	ADJ
fnp-3806	1278	171	lineage	lineage	NOUN
fnp-3806	1278	172	kinase	kinase	NOUN
fnp-3806	1278	173	domain	domain	NOUN
fnp-3806	1278	174	-	-	PUNCT
fnp-3806	1278	175	like	like	ADJ
fnp-3806	1278	176	protein	protein	NOUN
fnp-3806	1278	177	,	,	PUNCT
fnp-3806	1278	178	mobp	mobp	VERB
fnp-3806	1278	179	myelin	myelin	NOUN
fnp-3806	1278	180	-	-	PUNCT
fnp-3806	1278	181	associated	associate	VERB
fnp-3806	1278	182	oligodendrocyte	oligodendrocyte	ADJ
fnp-3806	1278	183	basic	basic	ADJ
fnp-3806	1278	184	protein	protein	NOUN
fnp-3806	1278	185	,	,	PUNCT
fnp-3806	1278	186	mog	mog	NOUN
fnp-3806	1278	187	myelin	myelin	NOUN
fnp-3806	1278	188	-	-	PUNCT
fnp-3806	1278	189	oligodendrocyte	oligodendrocyte	NOUN
fnp-3806	1278	190	glycoprotein	glycoprotein	NOUN
fnp-3806	1278	191	,	,	PUNCT
fnp-3806	1278	192	mri	mri	NOUN
fnp-3806	1278	193	magnetic	magnetic	ADJ
fnp-3806	1278	194	resonance	resonance	NOUN
fnp-3806	1278	195	imaging	imaging	NOUN
fnp-3806	1278	196	,	,	PUNCT
fnp-3806	1278	197	msa4	msa4	PROPN
fnp-3806	1278	198	membrane	membrane	NOUN
fnp-3806	1278	199	-	-	PUNCT
fnp-3806	1278	200	spanning	span	VERB
fnp-3806	1278	201	4	4	NUM
fnp-3806	1278	202	-	-	PUNCT
fnp-3806	1278	203	domains	domain	NOUN
fnp-3806	1278	204	subfamily	subfamily	ADV
fnp-3806	1278	205	a	a	X
fnp-3806	1278	206	,	,	PUNCT
fnp-3806	1278	207	mtrnas	mtrnas	PROPN
fnp-3806	1278	208	mitochondrial	mitochondrial	ADJ
fnp-3806	1278	209	rnas	rna	NOUN
fnp-3806	1278	210	,	,	PUNCT
fnp-3806	1278	211	mufa	mufa	NOUN
fnp-3806	1278	212	monounsaturated	monounsaturate	VERB
fnp-3806	1278	213	fatty	fatty	NOUN
fnp-3806	1278	214	acids	acid	NOUN
fnp-3806	1278	215	,	,	PUNCT
fnp-3806	1278	216	nachr	nachr	NOUN
fnp-3806	1278	217	nicotinic	nicotinic	ADJ
fnp-3806	1278	218	acetylcholine	acetylcholine	NOUN
fnp-3806	1278	219	receptor	receptor	NOUN
fnp-3806	1278	220	,	,	PUNCT
fnp-3806	1278	221	nadþ	nadþ	NOUN
fnp-3806	1278	222	nicotinamide	nicotinamide	NOUN
fnp-3806	1278	223	adenine	adenine	ADJ
fnp-3806	1278	224	dinucleotide	dinucleotide	NOUN
fnp-3806	1278	225	,	,	PUNCT
fnp-3806	1278	226	nadpþ	nadpþ	ADJ
fnp-3806	1278	227	nicotinamide	nicotinamide	NOUN
fnp-3806	1278	228	adenine	adenine	ADJ
fnp-3806	1278	229	dinucleotide	dinucleotide	NOUN
fnp-3806	1278	230	phosphate	phosphate	NOUN
fnp-3806	1278	231	,	,	PUNCT
fnp-3806	1278	232	nct	nct	ADJ
fnp-3806	1278	233	/	/	SYM
fnp-3806	1278	234	ncstn	ncstn	NOUN
fnp-3806	1278	235	nicastrin	nicastrin	NOUN
fnp-3806	1278	236	,	,	PUNCT
fnp-3806	1278	237	nep	nep	PROPN
fnp-3806	1278	238	/	/	SYM
fnp-3806	1278	239	nme	nme	PROPN
fnp-3806	1278	240	neprelysin	neprelysin	PROPN
fnp-3806	1278	241	,	,	PUNCT
fnp-3806	1278	242	nft	nft	PROPN
fnp-3806	1278	243	neurofibrillary	neurofibrillary	PROPN
fnp-3806	1278	244	tangle	tangle	NOUN
fnp-3806	1278	245	,	,	PUNCT
fnp-3806	1278	246	ng2	ng2	NOUN
fnp-3806	1278	247	neural	neural	ADJ
fnp-3806	1278	248	/	/	SYM
fnp-3806	1278	249	glial	glial	ADJ
fnp-3806	1278	250	antigen	antigen	NOUN
fnp-3806	1278	251	2	2	NUM
fnp-3806	1278	252	,	,	PUNCT
fnp-3806	1278	253	ngf	ngf	ADJ
fnp-3806	1278	254	nerve	nerve	NOUN
fnp-3806	1278	255	growth	growth	NOUN
fnp-3806	1278	256	factor	factor	NOUN
fnp-3806	1278	257	,	,	PUNCT
fnp-3806	1278	258	nia	nia	PROPN
fnp-3806	1278	259	-	-	PUNCT
fnp-3806	1278	260	aa	aa	PROPN
fnp-3806	1278	261	national	national	PROPN
fnp-3806	1278	262	institute	institute	PROPN
fnp-3806	1278	263	on	on	ADP
fnp-3806	1278	264	aging	age	VERB
fnp-3806	1278	265	–	–	PUNCT
fnp-3806	1278	266	alzheimer	alzheimer	PROPN
fnp-3806	1278	267	’s	’s	PROPN
fnp-3806	1278	268	association	association	PROPN
fnp-3806	1278	269	,	,	PUNCT
fnp-3806	1278	270	nlrp3r	nlrp3r	PROPN
fnp-3806	1278	271	pyrin	pyrin	NOUN
fnp-3806	1278	272	-	-	PUNCT
fnp-3806	1278	273	domain	domain	NOUN
fnp-3806	1278	274	containing	contain	VERB
fnp-3806	1278	275	3	3	NUM
fnp-3806	1278	276	,	,	PUNCT
fnp-3806	1278	277	nmda	nmda	ADJ
fnp-3806	1278	278	n	n	CCONJ
fnp-3806	1278	279	-	-	PUNCT
fnp-3806	1278	280	methyl	methyl	NOUN
fnp-3806	1278	281	d	d	NOUN
fnp-3806	1278	282	-	-	NOUN
fnp-3806	1278	283	aspartate	aspartate	ADJ
fnp-3806	1278	284	,	,	PUNCT
fnp-3806	1278	285	nmdar	nmdar	NOUN
fnp-3806	1278	286	n	n	CCONJ
fnp-3806	1278	287	-	-	PUNCT
fnp-3806	1278	288	methyl	methyl	NOUN
fnp-3806	1278	289	-	-	PUNCT
fnp-3806	1278	290	d	d	NOUN
fnp-3806	1278	291	-	-	PUNCT
fnp-3806	1278	292	aspartate	aspartate	ADJ
fnp-3806	1278	293	receptor	receptor	NOUN
fnp-3806	1278	294	,	,	PUNCT
fnp-3806	1278	295	nor	nor	CCONJ
fnp-3806	1278	296	nuclear	nuclear	ADJ
fnp-3806	1278	297	iorganizer	iorganizer	NOUN
fnp-3806	1278	298	region	region	NOUN
fnp-3806	1278	299	,	,	PUNCT
fnp-3806	1278	300	npm1	npm1	NOUN
fnp-3806	1278	301	nucleophosmin	nucleophosmin	VERB
fnp-3806	1278	302	1	1	NUM
fnp-3806	1278	303	,	,	PUNCT
fnp-3806	1278	304	nrnas	nrnas	PROPN
fnp-3806	1278	305	small	small	ADJ
fnp-3806	1278	306	non	non	ADJ
fnp-3806	1278	307	-	-	ADJ
fnp-3806	1278	308	coding	coding	ADJ
fnp-3806	1278	309	rnas	rna	NOUN
fnp-3806	1278	310	,	,	PUNCT
fnp-3806	1278	311	opc	opc	PROPN
fnp-3806	1278	312	oligodendroglial	oligodendroglial	ADJ
fnp-3806	1278	313	precurosor	precurosor	NOUN
fnp-3806	1278	314	cells	cell	NOUN
fnp-3806	1278	315	,	,	PUNCT
fnp-3806	1278	316	part	part	NOUN
fnp-3806	1278	317	primary	primary	ADJ
fnp-3806	1278	318	age	age	NOUN
fnp-3806	1278	319	-	-	PUNCT
fnp-3806	1278	320	related	relate	VERB
fnp-3806	1278	321	tauopathy	tauopathy	NOUN
fnp-3806	1278	322	,	,	PUNCT
fnp-3806	1278	323	p75ntr	p75ntr	NOUN
fnp-3806	1278	324	p75	p75	ADJ
fnp-3806	1278	325	neurotrophin	neurotrophin	ADJ
fnp-3806	1278	326	receptor	receptor	NOUN
fnp-3806	1278	327	,	,	PUNCT
fnp-3806	1278	328	low	low	ADJ
fnp-3806	1278	329	affinity	affinity	NOUN
fnp-3806	1278	330	nerve	nerve	NOUN
fnp-3806	1278	331	growth	growth	NOUN
fnp-3806	1278	332	factor	factor	NOUN
fnp-3806	1278	333	receptor	receptor	NOUN
fnp-3806	1278	334	,	,	PUNCT
fnp-3806	1278	335	pdgfra	pdgfra	NOUN
fnp-3806	1278	336	platelet	platelet	NOUN
fnp-3806	1278	337	-	-	PUNCT
fnp-3806	1278	338	derived	derive	VERB
fnp-3806	1278	339	growth	growth	NOUN
fnp-3806	1278	340	factor	factor	NOUN
fnp-3806	1278	341	receptor	receptor	NOUN
fnp-3806	1278	342	a	a	PRON
fnp-3806	1278	343	,	,	PUNCT
fnp-3806	1278	344	pen2	pen2	NOUN
fnp-3806	1278	345	/	/	SYM
fnp-3806	1278	346	psenen	psenen	NOUN
fnp-3806	1278	347	presenilin	presenilin	PROPN
fnp-3806	1278	348	enhancer	enhancer	NOUN
fnp-3806	1278	349	γ	γ	PROPN
fnp-3806	1278	350	-	-	ADJ
fnp-3806	1278	351	secretase	secretase	ADJ
fnp-3806	1278	352	subunit	subunit	NOUN
fnp-3806	1278	353	,	,	PUNCT
fnp-3806	1278	354	perk	perk	NOUN
fnp-3806	1278	355	pkr	pkr	PROPN
fnp-3806	1278	356	-	-	PUNCT
fnp-3806	1278	357	like	like	ADJ
fnp-3806	1278	358	endoplasmic	endoplasmic	ADJ
fnp-3806	1278	359	reticulum	reticulum	NOUN
fnp-3806	1278	360	kinase	kinase	NOUN
fnp-3806	1278	361	,	,	PUNCT
fnp-3806	1278	362	pet	pet	ADJ
fnp-3806	1278	363	positron	positron	NOUN
fnp-3806	1278	364	emission	emission	NOUN
fnp-3806	1278	365	tomography	tomography	NOUN
fnp-3806	1278	366	,	,	PUNCT
fnp-3806	1278	367	phf	phf	NOUN
fnp-3806	1278	368	paired	pair	VERB
fnp-3806	1278	369	helical	helical	ADJ
fnp-3806	1278	370	filament	filament	NOUN
fnp-3806	1278	371	,	,	PUNCT
fnp-3806	1278	372	pi3k	pi3k	PROPN
fnp-3806	1278	373	phosphatidylinositol	phosphatidylinositol	NOUN
fnp-3806	1278	374	3	3	NUM
fnp-3806	1278	375	-	-	PUNCT
fnp-3806	1278	376	kinase	kinase	NOUN
fnp-3806	1278	377	,	,	PUNCT
fnp-3806	1278	378	pi3p	pi3p	VERB
fnp-3806	1278	379	phosphatidylinositol	phosphatidylinositol	NOUN
fnp-3806	1278	380	trisphosphate	trisphosphate	NOUN
fnp-3806	1278	381	,	,	PUNCT
fnp-3806	1278	382	picalm	picalm	ADJ
fnp-3806	1278	383	phosphatidylinositol	phosphatidylinositol	NOUN
fnp-3806	1278	384	binding	bind	VERB
fnp-3806	1278	385	clathrin	clathrin	NOUN
fnp-3806	1278	386	assembly	assembly	NOUN
fnp-3806	1278	387	protein	protein	NOUN
fnp-3806	1278	388	,	,	PUNCT
fnp-3806	1278	389	pid	pid	NOUN
fnp-3806	1278	390	pick	pick	NOUN
fnp-3806	1278	391	disease	disease	NOUN
fnp-3806	1278	392	,	,	PUNCT
fnp-3806	1278	393	pilra	pilra	ADV
fnp-3806	1278	394	paired	pair	VERB
fnp-3806	1278	395	immunoglobin	immunoglobin	NOUN
fnp-3806	1278	396	like	like	ADP
fnp-3806	1278	397	type	type	NOUN
fnp-3806	1278	398	2	2	NUM
fnp-3806	1278	399	receptor	receptor	NOUN
fnp-3806	1278	400	alpha	alpha	NOUN
fnp-3806	1278	401	,	,	PUNCT
fnp-3806	1278	402	pirb	pirb	NOUN
fnp-3806	1278	403	paired	pair	VERB
fnp-3806	1278	404	immunoglobulin	immunoglobulin	NOUN
fnp-3806	1278	405	-	-	PUNCT
fnp-3806	1278	406	like	like	ADJ
fnp-3806	1278	407	receptor	receptor	NOUN
fnp-3806	1278	408	b	b	PROPN
fnp-3806	1278	409	,	,	PUNCT
fnp-3806	1278	410	pirnas	pirnas	PROPN
fnp-3806	1278	411	piwi	piwi	NOUN
fnp-3806	1278	412	-	-	PUNCT
fnp-3806	1278	413	interacting	interact	VERB
fnp-3806	1278	414	rnas	rna	NOUN
fnp-3806	1278	415	,	,	PUNCT
fnp-3806	1278	416	pka	pka	PROPN
fnp-3806	1278	417	protein	protein	NOUN
fnp-3806	1278	418	kinase	kinase	VERB
fnp-3806	1278	419	a	a	PRON
fnp-3806	1278	420	,	,	PUNCT
fnp-3806	1278	421	pkc	pkc	PROPN
fnp-3806	1278	422	protein	protein	NOUN
fnp-3806	1278	423	kinase	kinase	PROPN
fnp-3806	1278	424	c	c	PROPN
fnp-3806	1278	425	,	,	PUNCT
fnp-3806	1278	426	plc	plc	PROPN
fnp-3806	1278	427	phospholipase	phospholipase	PROPN
fnp-3806	1278	428	c	c	PROPN
fnp-3806	1278	429	,	,	PUNCT
fnp-3806	1278	430	plp1	plp1	ADJ
fnp-3806	1278	431	proteolipid	proteolipid	NOUN
fnp-3806	1278	432	protein	protein	NOUN
fnp-3806	1278	433	1	1	NUM
fnp-3806	1278	434	,	,	PUNCT
fnp-3806	1278	435	ppar	ppar	NOUN
fnp-3806	1278	436	peroxisome	peroxisome	VERB
fnp-3806	1278	437	proliferator	proliferator	NOUN
fnp-3806	1278	438	-	-	PUNCT
fnp-3806	1278	439	activated	activate	VERB
fnp-3806	1278	440	receptors	receptor	NOUN
fnp-3806	1278	441	,	,	PUNCT
fnp-3806	1278	442	prnp	prnp	VERB
fnp-3806	1278	443	prion	prion	NOUN
fnp-3806	1278	444	protein	protein	NOUN
fnp-3806	1278	445	gene	gene	NOUN
fnp-3806	1278	446	,	,	PUNCT
fnp-3806	1278	447	prpc	prpc	ADJ
fnp-3806	1278	448	cellular	cellular	ADJ
fnp-3806	1278	449	prion	prion	NOUN
fnp-3806	1278	450	protein	protein	NOUN
fnp-3806	1278	451	,	,	PUNCT
fnp-3806	1278	452	psen1	psen1	ADJ
fnp-3806	1278	453	presenilin	presenilin	PROPN
fnp-3806	1278	454	1	1	NUM
fnp-3806	1278	455	,	,	PUNCT
fnp-3806	1278	456	psen2	psen2	NOUN
fnp-3806	1278	457	presenilin	presenilin	NOUN
fnp-3806	1278	458	2	2	NUM
fnp-3806	1278	459	,	,	PUNCT
fnp-3806	1278	460	ptk2b	ptk2b	VERB
fnp-3806	1278	461	protein	protein	NOUN
fnp-3806	1278	462	tyrosine	tyrosine	NOUN
fnp-3806	1278	463	kinase	kinase	PROPN
fnp-3806	1278	464	2	2	NUM
fnp-3806	1278	465	beta	beta	NOUN
fnp-3806	1278	466	,	,	PUNCT
fnp-3806	1278	467	pufa	pufa	PROPN
fnp-3806	1278	468	polyunsaturated	polyunsaturate	VERB
fnp-3806	1278	469	fatty	fatty	NOUN
fnp-3806	1278	470	acids	acid	NOUN
fnp-3806	1278	471	,	,	PUNCT
fnp-3806	1278	472	pv	pv	NOUN
fnp-3806	1278	473	parvalbumin	parvalbumin	NOUN
fnp-3806	1278	474	,	,	PUNCT
fnp-3806	1278	475	rab10	rab10	NOUN
fnp-3806	1278	476	ras	ra	VERB
fnp-3806	1278	477	-	-	PUNCT
fnp-3806	1278	478	related	relate	VERB
fnp-3806	1278	479	protein	protein	NOUN
fnp-3806	1278	480	rab-10	rab-10	NOUN
fnp-3806	1278	481	,	,	PUNCT
fnp-3806	1278	482	rage	rage	NOUN
fnp-3806	1278	483	age	age	NOUN
fnp-3806	1278	484	receptor	receptor	NOUN
fnp-3806	1278	485	,	,	PUNCT
fnp-3806	1278	486	rest	rest	NOUN
fnp-3806	1278	487	re1	re1	PROPN
fnp-3806	1278	488	-	-	PUNCT
fnp-3806	1278	489	silencing	silence	VERB
fnp-3806	1278	490	transcription	transcription	NOUN
fnp-3806	1278	491	factor	factor	NOUN
fnp-3806	1278	492	,	,	PUNCT
fnp-3806	1278	493	rip3	rip3	NOUN
fnp-3806	1278	494	receptor	receptor	NOUN
fnp-3806	1278	495	interacting	interact	VERB
fnp-3806	1278	496	protein	protein	NOUN
fnp-3806	1278	497	3	3	NUM
fnp-3806	1278	498	,	,	PUNCT
fnp-3806	1278	499	rns	rn	VERB
fnp-3806	1278	500	reactive	reactive	ADJ
fnp-3806	1278	501	nitrogen	nitrogen	NOUN
fnp-3806	1278	502	species	specie	NOUN
fnp-3806	1278	503	,	,	PUNCT
fnp-3806	1278	504	rorb	rorb	NOUN
fnp-3806	1278	505	rar	rar	NOUN
fnp-3806	1278	506	related	relate	VERB
fnp-3806	1278	507	orphan	orphan	NOUN
fnp-3806	1278	508	receptor	receptor	NOUN
fnp-3806	1278	509	b	b	NOUN
fnp-3806	1278	510	,	,	PUNCT
fnp-3806	1278	511	ros	ros	PROPN
fnp-3806	1278	512	reactive	reactive	ADJ
fnp-3806	1278	513	oxygen	oxygen	NOUN
fnp-3806	1278	514	species	specie	NOUN
fnp-3806	1278	515	,	,	PUNCT
fnp-3806	1278	516	rp	rp	NOUN
fnp-3806	1278	517	ribosomal	ribosomal	NOUN
fnp-3806	1278	518	protein	protein	NOUN
fnp-3806	1278	519	,	,	PUNCT
fnp-3806	1278	520	rpad	rpad	NOUN
fnp-3806	1278	521	rapidly	rapidly	ADV
fnp-3806	1278	522	progressive	progressive	ADJ
fnp-3806	1278	523	ad	ad	NOUN
fnp-3806	1278	524	,	,	PUNCT
fnp-3806	1278	525	rrna	rrna	PROPN
fnp-3806	1278	526	ribosomal	ribosomal	PROPN
fnp-3806	1278	527	rna	rna	PROPN
fnp-3806	1278	528	,	,	PUNCT
fnp-3806	1278	529	sad	sad	ADJ
fnp-3806	1278	530	sporadic	sporadic	ADJ
fnp-3806	1278	531	alzheimer	alzheimer	PROPN
fnp-3806	1278	532	disease	disease	NOUN
fnp-3806	1278	533	,	,	PUNCT
fnp-3806	1278	534	sam	sam	PROPN
fnp-3806	1278	535	s	s	PROPN
fnp-3806	1278	536	-	-	PUNCT
fnp-3806	1278	537	adenosyl	adenosyl	ADJ
fnp-3806	1278	538	-	-	PUNCT
fnp-3806	1278	539	l	l	NOUN
fnp-3806	1278	540	-	-	NOUN
fnp-3806	1278	541	methionine	methionine	NOUN
fnp-3806	1278	542	,	,	PUNCT
fnp-3806	1278	543	sapk	sapk	PROPN
fnp-3806	1278	544	/	/	SYM
fnp-3806	1278	545	jnk	jnk	PROPN
fnp-3806	1278	546	stress	stress	NOUN
fnp-3806	1278	547	-	-	PUNCT
fnp-3806	1278	548	activated	activate	VERB
fnp-3806	1278	549	protein	protein	NOUN
fnp-3806	1278	550	kinase	kinase	PROPN
fnp-3806	1278	551	/	/	SYM
fnp-3806	1278	552	jun	jun	PROPN
fnp-3806	1278	553	n	n	CCONJ
fnp-3806	1278	554	-	-	PUNCT
fnp-3806	1278	555	terminal	terminal	ADJ
fnp-3806	1278	556	kinase	kinase	NOUN
fnp-3806	1278	557	,	,	PUNCT
fnp-3806	1278	558	scarnas	scarna	VERB
fnp-3806	1278	559	small	small	ADJ
fnp-3806	1278	560	cajal	cajal	ADJ
fnp-3806	1278	561	-	-	PUNCT
fnp-3806	1278	562	body	body	NOUN
fnp-3806	1278	563	specific	specific	ADJ
fnp-3806	1278	564	rnas	rna	NOUN
fnp-3806	1278	565	,	,	PUNCT
fnp-3806	1278	566	sfpq	sfpq	NOUN
fnp-3806	1278	567	splicing	splicing	NOUN
fnp-3806	1278	568	factor	factor	NOUN
fnp-3806	1278	569	proline	proline	NOUN
fnp-3806	1278	570	and	and	CCONJ
fnp-3806	1278	571	glutamine	glutamine	NOUN
fnp-3806	1278	572	rich	rich	ADJ
fnp-3806	1278	573	,	,	PUNCT
fnp-3806	1278	574	sirnas	sirnas	PROPN
fnp-3806	1278	575	small	small	ADJ
fnp-3806	1278	576	interfering	interfere	VERB
fnp-3806	1278	577	rnas	rna	NOUN
fnp-3806	1278	578	,	,	PUNCT
fnp-3806	1278	579	snap	snap	VERB
fnp-3806	1278	580	soluble	soluble	ADJ
fnp-3806	1278	581	nsf	nsf	NOUN
fnp-3806	1278	582	attachment	attachment	NOUN
fnp-3806	1278	583	protein	protein	NOUN
fnp-3806	1278	584	receptor	receptor	NOUN
fnp-3806	1278	585	,	,	PUNCT
fnp-3806	1278	586	snare	snare	NOUN
fnp-3806	1278	587	snap	snap	ADJ
fnp-3806	1278	588	receptor	receptor	NOUN
fnp-3806	1278	589	protein	protein	NOUN
fnp-3806	1278	590	,	,	PUNCT
fnp-3806	1278	591	snrnaseq	snrnaseq	ADJ
fnp-3806	1278	592	single	single	ADJ
fnp-3806	1278	593	nuclei	nucleus	NOUN
fnp-3806	1278	594	rna	rna	NOUN
fnp-3806	1278	595	sequencing	sequencing	NOUN
fnp-3806	1278	596	,	,	PUNCT
fnp-3806	1278	597	snrna	snrna	ADJ
fnp-3806	1278	598	small	small	ADJ
fnp-3806	1278	599	nuclear	nuclear	ADJ
fnp-3806	1278	600	rnas	rna	NOUN
fnp-3806	1278	601	,	,	PUNCT
fnp-3806	1278	602	snornas	snornas	PROPN
fnp-3806	1278	603	small	small	ADJ
fnp-3806	1278	604	nucleolar	nucleolar	ADJ
fnp-3806	1278	605	rnas	rna	NOUN
fnp-3806	1278	606	,	,	PUNCT
fnp-3806	1278	607	sorl1	sorl1	PROPN
fnp-3806	1278	608	sortilin	sortilin	PROPN
fnp-3806	1278	609	-	-	PUNCT
fnp-3806	1278	610	related	relate	VERB
fnp-3806	1278	611	receptor	receptor	NOUN
fnp-3806	1278	612	1	1	NUM
fnp-3806	1278	613	,	,	PUNCT
fnp-3806	1278	614	spi1	spi1	PROPN
fnp-3806	1278	615	spi-1	spi-1	ADV
fnp-3806	1278	616	proto	proto	NOUN
fnp-3806	1278	617	-	-	PUNCT
fnp-3806	1278	618	oncogene	oncogene	NOUN
fnp-3806	1278	619	,	,	PUNCT
fnp-3806	1278	620	sp	sp	ADP
fnp-3806	1278	621	senile	senile	ADJ
fnp-3806	1278	622	plaque	plaque	NOUN
fnp-3806	1278	623	,	,	PUNCT
fnp-3806	1278	624	stat1	stat1	X
fnp-3806	1278	625	signal	signal	NOUN
fnp-3806	1278	626	transducer	transducer	NOUN
fnp-3806	1278	627	and	and	CCONJ
fnp-3806	1278	628	activator	activator	NOUN
fnp-3806	1278	629	of	of	ADP
fnp-3806	1278	630	transcription	transcription	NOUN
fnp-3806	1278	631	1	1	NUM
fnp-3806	1278	632	,	,	PUNCT
fnp-3806	1278	633	tet1	tet1	NOUN
fnp-3806	1278	634	ten	ten	NUM
fnp-3806	1278	635	-	-	PUNCT
fnp-3806	1278	636	eleven	eleven	NUM
fnp-3806	1278	637	-	-	PUNCT
fnp-3806	1278	638	translocation-1	translocation-1	NUM
fnp-3806	1278	639	protein	protein	NOUN
fnp-3806	1278	640	,	,	PUNCT
fnp-3806	1278	641	tgf	tgf	PROPN
fnp-3806	1278	642	transforming	transform	VERB
fnp-3806	1278	643	growth	growth	NOUN
fnp-3806	1278	644	factor	factor	NOUN
fnp-3806	1278	645	,	,	PUNCT
fnp-3806	1278	646	tlr	tlr	PROPN
fnp-3806	1278	647	toll	toll	NOUN
fnp-3806	1278	648	like	like	ADP
fnp-3806	1278	649	receptor	receptor	NOUN
fnp-3806	1278	650	,	,	PUNCT
fnp-3806	1278	651	tnf	tnf	PROPN
fnp-3806	1278	652	tumor	tumor	NOUN
fnp-3806	1278	653	necrosis	necrosis	NOUN
fnp-3806	1278	654	factor	factor	NOUN
fnp-3806	1278	655	,	,	PUNCT
fnp-3806	1278	656	tor	tor	NOUN
fnp-3806	1278	657	target	target	NOUN
fnp-3806	1278	658	of	of	ADP
fnp-3806	1278	659	rapamycin	rapamycin	NOUN
fnp-3806	1278	660	,	,	PUNCT
fnp-3806	1278	661	traf2	traf2	NOUN
fnp-3806	1278	662	tnf	tnf	PROPN
fnp-3806	1278	663	receptor	receptor	NOUN
fnp-3806	1278	664	-	-	PUNCT
fnp-3806	1278	665	associated	associate	VERB
fnp-3806	1278	666	factor	factor	NOUN
fnp-3806	1278	667	2	2	NUM
fnp-3806	1278	668	,	,	PUNCT
fnp-3806	1278	669	trem2	trem2	NOUN
fnp-3806	1278	670	triggering	trigger	VERB
fnp-3806	1278	671	receptor	receptor	NOUN
fnp-3806	1278	672	expressed	express	VERB
fnp-3806	1278	673	on	on	ADP
fnp-3806	1278	674	myeloid	myeloid	ADJ
fnp-3806	1278	675	cells	cell	NOUN
fnp-3806	1278	676	2	2	NUM
fnp-3806	1278	677	,	,	PUNCT
fnp-3806	1278	678	trka	trka	PRON
fnp-3806	1278	679	specific	specific	ADJ
fnp-3806	1278	680	ngf	ngf	ADJ
fnp-3806	1278	681	receptor	receptor	NOUN
fnp-3806	1278	682	,	,	PUNCT
fnp-3806	1278	683	trna	trna	NOUN
fnp-3806	1278	684	transfer	transfer	NOUN
fnp-3806	1278	685	rnas	rna	NOUN
fnp-3806	1278	686	,	,	PUNCT
fnp-3806	1278	687	ubtf	ubtf	ADJ
fnp-3806	1278	688	upstream	upstream	ADJ
fnp-3806	1278	689	binding	bind	VERB
fnp-3806	1278	690	transcription	transcription	NOUN
fnp-3806	1278	691	factor	factor	NOUN
fnp-3806	1278	692	rna	rna	NOUN
fnp-3806	1278	693	polymerase	polymerase	NOUN
fnp-3806	1278	694	i	i	PRON
fnp-3806	1278	695	gene	gene	VERB
fnp-3806	1278	696	,	,	PUNCT
fnp-3806	1278	697	uchl-1	uchl-1	CCONJ
fnp-3806	1278	698	ubiquitin	ubiquitin	NOUN
fnp-3806	1278	699	c	c	ADJ
fnp-3806	1278	700	-	-	PUNCT
fnp-3806	1278	701	terminal	terminal	ADJ
fnp-3806	1278	702	hydrolase	hydrolase	NOUN
fnp-3806	1278	703	l1	l1	PROPN
fnp-3806	1278	704	,	,	PUNCT
fnp-3806	1278	705	upr	upr	NOUN
fnp-3806	1278	706	misfolded	misfolde	VERB
fnp-3806	1278	707	protein	protein	NOUN
fnp-3806	1278	708	response	response	NOUN
fnp-3806	1278	709	,	,	PUNCT
fnp-3806	1278	710	ups	up	NOUN
fnp-3806	1278	711	ubiquitin	ubiquitin	ADJ
fnp-3806	1278	712	proteasome	proteasome	NOUN
fnp-3806	1278	713	system	system	NOUN
fnp-3806	1278	714	,	,	PUNCT
fnp-3806	1278	715	vgat	vgat	ADJ
fnp-3806	1278	716	vesicular	vesicular	ADJ
fnp-3806	1278	717	gaba	gaba	NOUN
fnp-3806	1278	718	transporter	transporter	NOUN
fnp-3806	1278	719	,	,	PUNCT
fnp-3806	1278	720	vglut	vglut	NOUN
fnp-3806	1278	721	vesicular	vesicular	ADJ
fnp-3806	1278	722	glutamate	glutamate	ADJ
fnp-3806	1278	723	transporter	transporter	NOUN
fnp-3806	1278	724	,	,	PUNCT
fnp-3806	1278	725	vmat	vmat	ADJ
fnp-3806	1278	726	vesicular	vesicular	ADJ
fnp-3806	1278	727	monoamino	monoamino	NOUN
fnp-3806	1278	728	transporter	transporter	NOUN
fnp-3806	1278	729	,	,	PUNCT
fnp-3806	1278	730	wm	wm	PROPN
fnp-3806	1278	731	white	white	PROPN
fnp-3806	1278	732	matter	matter	NOUN
fnp-3806	1278	733	,	,	PUNCT
fnp-3806	1278	734	wt	wt	ADP
fnp-3806	1278	735	wild	wild	ADJ
fnp-3806	1278	736	type	type	NOUN
fnp-3806	1278	737	,	,	PUNCT
fnp-3806	1278	738	xbp-1	xbp-1	PUNCT
fnp-3806	1278	739	x	x	PROPN
fnp-3806	1278	740	-	-	NOUN
fnp-3806	1278	741	box	box	NOUN
fnp-3806	1278	742	binding	bind	VERB
fnp-3806	1278	743	protein	protein	NOUN
fnp-3806	1278	744	1	1	NUM
fnp-3806	1278	745	.	.	PUNCT
fnp-3806	1279	1	funding	fund	VERB
fnp-3806	1279	2	the	the	DET
fnp-3806	1279	3	project	project	NOUN
fnp-3806	1279	4	leading	lead	VERB
fnp-3806	1279	5	to	to	ADP
fnp-3806	1279	6	these	these	DET
fnp-3806	1279	7	results	result	NOUN
fnp-3806	1279	8	received	receive	VERB
fnp-3806	1279	9	funding	funding	NOUN
fnp-3806	1279	10	from	from	ADP
fnp-3806	1279	11	the	the	DET
fnp-3806	1279	12	“	"	PUNCT
fnp-3806	1279	13	la	la	X
fnp-3806	1279	14	caixa	caixa	PROPN
fnp-3806	1279	15	”	"	PUNCT
fnp-3806	1279	16	foundation	foundation	NOUN
fnp-3806	1279	17	(	(	PUNCT
fnp-3806	1279	18	i	i	NOUN
fnp-3806	1279	19	d	d	PROPN
fnp-3806	1279	20	100010434	100010434	NUM
fnp-3806	1279	21	)	)	PUNCT
fnp-3806	1279	22	under	under	ADP
fnp-3806	1279	23	the	the	DET
fnp-3806	1279	24	agreement	agreement	NOUN
fnp-3806	1279	25	lcf	lcf	PROPN
fnp-3806	1279	26	/	/	SYM
fnp-3806	1279	27	pr	pr	NOUN
fnp-3806	1279	28	/	/	SYM
fnp-3806	1279	29	hr19/52160007	hr19/52160007	PROPN
fnp-3806	1279	30	,	,	PUNCT
fnp-3806	1279	31	hr18	hr18	PROPN
fnp-3806	1279	32	-	-	PUNCT
fnp-3806	1279	33	00452	00452	NUM
fnp-3806	1279	34	.	.	PUNCT
fnp-3806	1280	1	i	i	PRON
fnp-3806	1280	2	thank	thank	VERB
fnp-3806	1280	3	the	the	DET
fnp-3806	1280	4	cerca	cerca	PROPN
fnp-3806	1280	5	programme	programme	NOUN
fnp-3806	1280	6	of	of	ADP
fnp-3806	1280	7	the	the	DET
fnp-3806	1280	8	generalitat	generalitat	PROPN
fnp-3806	1280	9	de	de	ADP
fnp-3806	1280	10	catalunya	catalunya	PROPN
fnp-3806	1280	11	for	for	ADP
fnp-3806	1280	12	institutional	institutional	ADJ
fnp-3806	1280	13	support	support	NOUN
fnp-3806	1280	14	.	.	PUNCT
fnp-3806	1281	1	acknowledgements	acknowledgement	NOUN
fnp-3806	1281	2	this	this	DET
fnp-3806	1281	3	work	work	NOUN
fnp-3806	1281	4	is	be	AUX
fnp-3806	1281	5	,	,	PUNCT
fnp-3806	1281	6	in	in	ADP
fnp-3806	1281	7	part	part	NOUN
fnp-3806	1281	8	,	,	PUNCT
fnp-3806	1281	9	the	the	DET
fnp-3806	1281	10	result	result	NOUN
fnp-3806	1281	11	of	of	ADP
fnp-3806	1281	12	the	the	DET
fnp-3806	1281	13	personal	personal	ADJ
fnp-3806	1281	14	experience	experience	NOUN
fnp-3806	1281	15	of	of	ADP
fnp-3806	1281	16	40	40	NUM
fnp-3806	1281	17	years	year	NOUN
fnp-3806	1281	18	in	in	ADP
fnp-3806	1281	19	the	the	DET
fnp-3806	1281	20	study	study	NOUN
fnp-3806	1281	21	of	of	ADP
fnp-3806	1281	22	ad	ad	NOUN
fnp-3806	1281	23	and	and	CCONJ
fnp-3806	1281	24	other	other	ADJ
fnp-3806	1281	25	tauopathies	tauopathie	NOUN
fnp-3806	1281	26	.	.	PUNCT
fnp-3806	1282	1	to	to	PART
fnp-3806	1282	2	name	name	VERB
fnp-3806	1282	3	all	all	DET
fnp-3806	1282	4	the	the	DET
fnp-3806	1282	5	people	people	NOUN
fnp-3806	1282	6	i	i	PRON
fnp-3806	1282	7	would	would	AUX
fnp-3806	1282	8	like	like	VERB
fnp-3806	1282	9	to	to	PART
fnp-3806	1282	10	thank	thank	VERB
fnp-3806	1282	11	for	for	ADP
fnp-3806	1282	12	their	their	PRON
fnp-3806	1282	13	help	help	NOUN
fnp-3806	1282	14	,	,	PUNCT
fnp-3806	1282	15	support	support	NOUN
fnp-3806	1282	16	,	,	PUNCT
fnp-3806	1282	17	and	and	CCONJ
fnp-3806	1282	18	satisfactory	satisfactory	ADJ
fnp-3806	1282	19	collaboration	collaboration	NOUN
fnp-3806	1282	20	is	be	AUX
fnp-3806	1282	21	practically	practically	ADV
fnp-3806	1282	22	impossible	impossible	ADJ
fnp-3806	1282	23	.	.	PUNCT
fnp-3806	1283	1	i	i	PRON
fnp-3806	1283	2	appreciate	appreciate	VERB
fnp-3806	1283	3	the	the	DET
fnp-3806	1283	4	aid	aid	NOUN
fnp-3806	1283	5	of	of	ADP
fnp-3806	1283	6	ciberned	ciberne	VERB
fnp-3806	1283	7	,	,	PUNCT
fnp-3806	1283	8	and	and	CCONJ
fnp-3806	1283	9	i	i	PRON
fnp-3806	1283	10	am	be	AUX
fnp-3806	1283	11	extremely	extremely	ADV
fnp-3806	1283	12	grateful	grateful	ADJ
fnp-3806	1283	13	to	to	ADP
fnp-3806	1283	14	tom	tom	PROPN
fnp-3806	1283	15	yohannan	yohannan	PROPN
fnp-3806	1283	16	for	for	ADP
fnp-3806	1283	17	his	his	PRON
fnp-3806	1283	18	continual	continual	ADJ
fnp-3806	1283	19	editorial	editorial	ADJ
fnp-3806	1283	20	assistance	assistance	NOUN
fnp-3806	1283	21	.	.	PUNCT
fnp-3806	1284	1	references	reference	NOUN
fnp-3806	1284	2	duyckaerts	duyckaert	NOUN
fnp-3806	1284	3	c	c	PROPN
fnp-3806	1284	4	,	,	PUNCT
fnp-3806	1284	5	dickson	dickson	PROPN
fnp-3806	1284	6	dw	dw	PROPN
fnp-3806	1284	7	.	.	PROPN
fnp-3806	1284	8	neuropathology	neuropathology	PROPN
fnp-3806	1284	9	of	of	ADP
fnp-3806	1284	10	alzheimer	alzheimer	PROPN
fnp-3806	1284	11	’s	’s	PART
fnp-3806	1284	12	disease	disease	NOUN
fnp-3806	1284	13	and	and	CCONJ
fnp-3806	1284	14	its	its	PRON
fnp-3806	1284	15	variants	variant	NOUN
fnp-3806	1284	16	.	.	PUNCT
fnp-3806	1285	1	in	in	ADP
fnp-3806	1285	2	:	:	PUNCT
fnp-3806	1285	3	neurodegeneration	neurodegeneration	NOUN
fnp-3806	1285	4	:	:	PUNCT
fnp-3806	1285	5	the	the	DET
fnp-3806	1285	6	molecular	molecular	ADJ
fnp-3806	1285	7	pathology	pathology	NOUN
fnp-3806	1285	8	of	of	ADP
fnp-3806	1285	9	dementia	dementia	NOUN
fnp-3806	1285	10	and	and	CCONJ
fnp-3806	1285	11	and	and	CCONJ
fnp-3806	1285	12	movement	movement	NOUN
fnp-3806	1285	13	disorders	disorder	NOUN
fnp-3806	1285	14	;	;	PUNCT
fnp-3806	1285	15	second	second	ADJ
fnp-3806	1285	16	edition	edition	NOUN
fnp-3806	1285	17	.	.	PUNCT
fnp-3806	1286	1	dickson	dickson	PROPN
fnp-3806	1286	2	dw	dw	PROPN
fnp-3806	1286	3	,	,	PUNCT
fnp-3806	1286	4	wetter	wetter	ADV
fnp-3806	1286	5	ro	ro	X
fnp-3806	1286	6	(	(	PUNCT
fnp-3806	1286	7	eds	ed	NOUN
fnp-3806	1286	8	)	)	PUNCT
fnp-3806	1286	9	international	international	ADJ
fnp-3806	1286	10	society	society	NOUN
fnp-3806	1286	11	of	of	ADP
fnp-3806	1286	12	neuropathology	neuropathology	NOUN
fnp-3806	1286	13	,	,	PUNCT
fnp-3806	1286	14	blackwell	blackwell	PROPN
fnp-3806	1286	15	publish	publish	VERB
fnp-3806	1286	16	ltd	ltd	PROPN
fnp-3806	1286	17	,	,	PUNCT
fnp-3806	1286	18	2011	2011	NUM
fnp-3806	1286	19	,	,	PUNCT
fnp-3806	1286	20	pp	pp	CCONJ
fnp-3806	1286	21	:	:	PUNCT
fnp-3806	1286	22	62	62	NUM
fnp-3806	1286	23	-	-	SYM
fnp-3806	1286	24	91	91	NUM
fnp-3806	1286	25	.	.	PUNCT
fnp-3806	1287	1	https://doi.org/10.1002/9781444341256.ch10	https://doi.org/10.1002/9781444341256.ch10	PROPN
fnp-3806	1287	2	knopman	knopman	PROPN
fnp-3806	1287	3	d.	d.	PROPN
fnp-3806	1287	4	clinical	clinical	PROPN
fnp-3806	1287	5	aspects	aspect	NOUN
fnp-3806	1287	6	of	of	ADP
fnp-3806	1287	7	alzheimer	alzheimer	PROPN
fnp-3806	1287	8	’s	’s	PART
fnp-3806	1287	9	disease	disease	NOUN
fnp-3806	1287	10	.	.	PUNCT
fnp-3806	1288	1	in	in	ADP
fnp-3806	1288	2	:	:	PUNCT
fnp-3806	1288	3	neurodegeneration	neurodegeneration	NOUN
fnp-3806	1288	4	,	,	PUNCT
fnp-3806	1288	5	the	the	DET
fnp-3806	1288	6	molecular	molecular	ADJ
fnp-3806	1288	7	pathology	pathology	NOUN
fnp-3806	1288	8	of	of	ADP
fnp-3806	1288	9	dementia	dementia	NOUN
fnp-3806	1288	10	and	and	CCONJ
fnp-3806	1288	11	movement	movement	NOUN
fnp-3806	1288	12	disorders	disorder	NOUN
fnp-3806	1288	13	.	.	PUNCT
fnp-3806	1289	1	dickson	dickson	PROPN
fnp-3806	1289	2	dw	dw	PROPN
fnp-3806	1289	3	,	,	PUNCT
fnp-3806	1289	4	weller	weller	PROPN
fnp-3806	1289	5	ro	ro	X
fnp-3806	1289	6	(	(	PUNCT
fnp-3806	1289	7	eds	ed	NOUN
fnp-3806	1289	8	)	)	PUNCT
fnp-3806	1289	9	wileyblackwell	wileyblackwell	ADJ
fnp-3806	1289	10	,	,	PUNCT
fnp-3806	1289	11	2011	2011	NUM
fnp-3806	1289	12	,	,	PUNCT
fnp-3806	1289	13	pp	pp	CCONJ
fnp-3806	1289	14	:	:	PUNCT
fnp-3806	1289	15	39	39	NUM
fnp-3806	1289	16	-	-	SYM
fnp-3806	1289	17	50	50	NUM
fnp-3806	1289	18	.	.	PUNCT
fnp-3806	1290	1	https://doi.org/10.1038/s41572-021-00269-y	https://doi.org/10.1038/s41572-021-00269-y	PROPN
fnp-3806	1290	2	serrano	serrano	PROPN
fnp-3806	1290	3	-	-	PUNCT
fnp-3806	1290	4	pozo	pozo	PROPN
fnp-3806	1290	5	a	a	PROPN
fnp-3806	1290	6	,	,	PUNCT
fnp-3806	1290	7	frosch	frosch	PROPN
fnp-3806	1290	8	mp	mp	PROPN
fnp-3806	1290	9	,	,	PUNCT
fnp-3806	1290	10	masliah	masliah	PROPN
fnp-3806	1290	11	e	e	PROPN
fnp-3806	1290	12	,	,	PUNCT
fnp-3806	1290	13	hyman	hyman	PROPN
fnp-3806	1290	14	bt	bt	PROPN
fnp-3806	1290	15	.	.	PROPN
fnp-3806	1290	16	neuropathological	neuropathological	ADJ
fnp-3806	1290	17	alterations	alteration	NOUN
fnp-3806	1290	18	in	in	ADP
fnp-3806	1290	19	alzheimer	alzheimer	PROPN
fnp-3806	1290	20	disease	disease	PROPN
fnp-3806	1290	21	.	.	PUNCT
fnp-3806	1291	1	cold	cold	ADJ
fnp-3806	1291	2	spring	spring	NOUN
fnp-3806	1291	3	harb	harb	PROPN
fnp-3806	1291	4	perspect	perspect	VERB
fnp-3806	1291	5	med	med	ADJ
fnp-3806	1291	6	2011;1	2011;1	NOUN
fnp-3806	1291	7	:	:	PUNCT
fnp-3806	1291	8	a006189	a006189	PROPN
fnp-3806	1291	9	.	.	PUNCT
fnp-3806	1292	1	https://doi.org/10.1101/cshperspect.a006189	https://doi.org/10.1101/cshperspect.a006189	PROPN
fnp-3806	1292	2	love	love	PROPN
fnp-3806	1292	3	j	j	PROPN
fnp-3806	1292	4	,	,	PUNCT
fnp-3806	1292	5	kalaria	kalaria	PROPN
fnp-3806	1292	6	r.	r.	PROPN
fnp-3806	1292	7	dementia	dementia	PROPN
fnp-3806	1292	8	.	.	PUNCT
fnp-3806	1293	1	in	in	ADP
fnp-3806	1293	2	:	:	PUNCT
fnp-3806	1293	3	greenfield	greenfield	NOUN
fnp-3806	1293	4	’s	’s	PART
fnp-3806	1293	5	neuropathology	neuropathology	NOUN
fnp-3806	1293	6	,	,	PUNCT
fnp-3806	1293	7	vol	vol	NOUN
fnp-3806	1293	8	1	1	NUM
fnp-3806	1293	9	,	,	PUNCT
fnp-3806	1293	10	nnth	nnth	PROPN
fnp-3806	1293	11	edition	edition	PROPN
fnp-3806	1293	12	.	.	PUNCT
fnp-3806	1294	1	love	love	PROPN
fnp-3806	1294	2	s	s	PROPN
fnp-3806	1294	3	,	,	PUNCT
fnp-3806	1294	4	budka	budka	ADJ
fnp-3806	1294	5	h	h	PROPN
fnp-3806	1294	6	,	,	PUNCT
fnp-3806	1294	7	ironside	ironside	PROPN
fnp-3806	1294	8	jw	jw	PROPN
fnp-3806	1294	9	,	,	PUNCT
fnp-3806	1294	10	perry	perry	PROPN
fnp-3806	1294	11	a	a	DET
fnp-3806	1294	12	(	(	PUNCT
fnp-3806	1294	13	eds	ed	NOUN
fnp-3806	1294	14	)	)	PUNCT
fnp-3806	1294	15	.	.	PUNCT
fnp-3806	1295	1	crc	crc	PROPN
fnp-3806	1295	2	press	press	PROPN
fnp-3806	1295	3	,	,	PUNCT
fnp-3806	1295	4	2015	2015	NUM
fnp-3806	1295	5	,	,	PUNCT
fnp-3806	1295	6	pp	pp	CCONJ
fnp-3806	1295	7	:	:	PUNCT
fnp-3806	1295	8	858	858	NUM
fnp-3806	1295	9	-	-	SYM
fnp-3806	1295	10	973	973	NUM
fnp-3806	1295	11	.	.	PUNCT
fnp-3806	1296	1	lowe	lowe	PROPN
fnp-3806	1296	2	j	j	PROPN
fnp-3806	1296	3	,	,	PUNCT
fnp-3806	1296	4	kalaria	kalaria	PROPN
fnp-3806	1296	5	r.	r.	PROPN
fnp-3806	1296	6	dementia	dementia	PROPN
fnp-3806	1296	7	.	.	PUNCT
fnp-3806	1297	1	in	in	ADP
fnp-3806	1297	2	:	:	PUNCT
fnp-3806	1297	3	greenfield	greenfield	NOUN
fnp-3806	1297	4	’s	’s	PART
fnp-3806	1297	5	neuropathology	neuropathology	NOUN
fnp-3806	1297	6	.	.	PUNCT
fnp-3806	1298	1	ninth	ninth	ADJ
fnp-3806	1298	2	edition	edition	PROPN
fnp-3806	1298	3	.	.	PUNCT
fnp-3806	1299	1	loe	loe	PROPN
fnp-3806	1300	1	s	s	PROPN
fnp-3806	1300	2	,	,	PUNCT
fnp-3806	1300	3	budka	budka	ADJ
fnp-3806	1300	4	h	h	PROPN
fnp-3806	1300	5	,	,	PUNCT
fnp-3806	1300	6	ironside	ironside	PROPN
fnp-3806	1300	7	jw	jw	PROPN
fnp-3806	1300	8	,	,	PUNCT
fnp-3806	1300	9	perry	perry	PROPN
fnp-3806	1300	10	a	a	DET
fnp-3806	1300	11	(	(	PUNCT
fnp-3806	1300	12	eds	ed	NOUN
fnp-3806	1300	13	)	)	PUNCT
fnp-3806	1300	14	.	.	PUNCT
fnp-3806	1301	1	crc	crc	PROPN
fnp-3806	1301	2	press	press	PROPN
fnp-3806	1301	3	2015	2015	NUM
fnp-3806	1301	4	,	,	PUNCT
fnp-3806	1301	5	pp	pp	CCONJ
fnp-3806	1301	6	:	:	PUNCT
fnp-3806	1301	7	858	858	NUM
fnp-3806	1301	8	-	-	SYM
fnp-3806	1301	9	973	973	NUM
fnp-3806	1301	10	.	.	PUNCT
fnp-3806	1302	1	masters	master	NOUN
fnp-3806	1302	2	cl	cl	PROPN
fnp-3806	1302	3	,	,	PUNCT
fnp-3806	1302	4	bateman	bateman	NOUN
fnp-3806	1302	5	r	r	PROPN
fnp-3806	1302	6	,	,	PUNCT
fnp-3806	1302	7	blennow	blennow	ADV
fnp-3806	1302	8	k	k	PROPN
fnp-3806	1302	9	,	,	PUNCT
fnp-3806	1302	10	et	et	PROPN
fnp-3806	1302	11	al	al	PROPN
fnp-3806	1302	12	.	.	PROPN
fnp-3806	1302	13	alzheimer	alzheimer	PROPN
fnp-3806	1302	14	's	's	PART
fnp-3806	1302	15	disease	disease	NOUN
fnp-3806	1302	16	.	.	PUNCT
fnp-3806	1303	1	nat	nat	PROPN
fnp-3806	1303	2	rev	rev	VERB
fnp-3806	1303	3	dis	dis	PROPN
fnp-3806	1303	4	primers	primer	NOUN
fnp-3806	1303	5	2015;1:15056	2015;1:15056	NOUN
fnp-3806	1303	6	.	.	PUNCT
fnp-3806	1304	1	https://doi.org/10.1038/nrdp.2015.56	https://doi.org/10.1038/nrdp.2015.56	DET
fnp-3806	1304	2	deture	deture	NOUN
fnp-3806	1304	3	ma	ma	PROPN
fnp-3806	1304	4	,	,	PUNCT
fnp-3806	1304	5	dickson	dickson	PROPN
fnp-3806	1304	6	dw	dw	PROPN
fnp-3806	1304	7	.	.	PUNCT
fnp-3806	1305	1	the	the	DET
fnp-3806	1305	2	neuropathological	neuropathological	ADJ
fnp-3806	1305	3	diagnosis	diagnosis	NOUN
fnp-3806	1305	4	of	of	ADP
fnp-3806	1305	5	alzheimer	alzheimer	PROPN
fnp-3806	1305	6	’s	’s	PART
fnp-3806	1305	7	disease	disease	NOUN
fnp-3806	1305	8	.	.	PUNCT
fnp-3806	1306	1	mol	mol	ADP
fnp-3806	1306	2	neurodeg	neurodeg	PROPN
fnp-3806	1306	3	2019;14:32	2019;14:32	NUM
fnp-3806	1306	4	.	.	PUNCT
fnp-3806	1307	1	https://doi.org/10.1186/s13024-019-0333-5	https://doi.org/10.1186/s13024-019-0333-5	NUM
fnp-3806	1307	2	jellinger	jellinger	PROPN
fnp-3806	1307	3	ka	ka	PROPN
fnp-3806	1307	4	.	.	PROPN
fnp-3806	1308	1	neuropathology	neuropathology	PROPN
fnp-3806	1308	2	of	of	ADP
fnp-3806	1308	3	the	the	DET
fnp-3806	1308	4	alzheimer	alzheimer	PROPN
fnp-3806	1308	5	’s	’s	PART
fnp-3806	1308	6	continuum	continuum	PROPN
fnp-3806	1308	7	:	:	PUNCT
fnp-3806	1308	8	an	an	DET
fnp-3806	1308	9	update	update	NOUN
fnp-3806	1308	10	.	.	PUNCT
fnp-3806	1309	1	free	free	ADJ
fnp-3806	1309	2	neuropathol	neuropathol	PROPN
fnp-3806	1309	3	2020;1:32	2020;1:32	PROPN
fnp-3806	1309	4	.	.	PUNCT
fnp-3806	1310	1	https://doi.org/10.17879/freeneuropathology-2020-3050	https://doi.org/10.17879/freeneuropathology-2020-3050	PROPN
fnp-3806	1311	1	avila	avila	PROPN
fnp-3806	1311	2	j	j	PROPN
fnp-3806	1311	3	,	,	PUNCT
fnp-3806	1311	4	perry	perry	PROPN
fnp-3806	1311	5	g.	g.	PROPN
fnp-3806	1311	6	a	a	DET
fnp-3806	1311	7	multilevel	multilevel	ADJ
fnp-3806	1311	8	view	view	NOUN
fnp-3806	1311	9	of	of	ADP
fnp-3806	1311	10	the	the	DET
fnp-3806	1311	11	development	development	NOUN
fnp-3806	1311	12	of	of	ADP
fnp-3806	1311	13	alzheimer	alzheimer	PROPN
fnp-3806	1311	14	’s	’s	PART
fnp-3806	1311	15	disease	disease	NOUN
fnp-3806	1311	16	.	.	PUNCT
fnp-3806	1312	1	neuroscience	neuroscience	NOUN
fnp-3806	1312	2	2021	2021	NUM
fnp-3806	1312	3	;	;	PUNCT
fnp-3806	1312	4	457	457	NUM
fnp-3806	1312	5	:	:	SYM
fnp-3806	1312	6	283	283	NUM
fnp-3806	1312	7	-	-	SYM
fnp-3806	1312	8	293	293	NUM
fnp-3806	1312	9	.	.	PUNCT
fnp-3806	1313	1	https://doi.org/10.1016/j.neuroscience.2020.11.015	https://doi.org/10.1016/j.neuroscience.2020.11.015	NUM
fnp-3806	1313	2	blocq	blocq	NOUN
fnp-3806	1313	3	p	p	PRON
fnp-3806	1313	4	,	,	PUNCT
fnp-3806	1313	5	marinesco	marinesco	PROPN
fnp-3806	1313	6	g.	g.	PROPN
fnp-3806	1313	7	sur	sur	PROPN
fnp-3806	1313	8	les	les	PROPN
fnp-3806	1313	9	lésions	lésion	NOUN
fnp-3806	1313	10	et	et	PROPN
fnp-3806	1313	11	la	la	PROPN
fnp-3806	1313	12	pathogénie	pathogénie	PROPN
fnp-3806	1313	13	de	de	PROPN
fnp-3806	1313	14	l’épilepsie	l’épilepsie	X
fnp-3806	1313	15	dite	dite	PROPN
fnp-3806	1313	16	essentielle	essentielle	X
fnp-3806	1313	17	.	.	PUNCT
fnp-3806	1314	1	sem	sem	PROPN
fnp-3806	1314	2	méd	méd	PROPN
fnp-3806	1314	3	1892	1892	NUM
fnp-3806	1314	4	;	;	PUNCT
fnp-3806	1314	5	12:445	12:445	NUM
fnp-3806	1314	6	-	-	SYM
fnp-3806	1314	7	446	446	NUM
fnp-3806	1314	8	.	.	PUNCT
fnp-3806	1315	1	redlich	redlich	PROPN
fnp-3806	1315	2	e.	e.	PROPN
fnp-3806	1315	3	uber	uber	PROPN
fnp-3806	1315	4	miliare	miliare	NOUN
fnp-3806	1315	5	sklerose	sklerose	ADJ
fnp-3806	1315	6	der	der	ADJ
fnp-3806	1315	7	hirnrinde	hirnrinde	NOUN
fnp-3806	1315	8	bei	bei	NOUN
fnp-3806	1315	9	seniler	seniler	NOUN
fnp-3806	1315	10	atrophie	atrophie	NOUN
fnp-3806	1315	11	.	.	PUNCT
fnp-3806	1316	1	jahrb	jahrb	PROPN
fnp-3806	1316	2	psychiat	psychiat	PROPN
fnp-3806	1316	3	neurol	neurol	PROPN
fnp-3806	1316	4	1898;17:208	1898;17:208	PROPN
fnp-3806	1316	5	-	-	SYM
fnp-3806	1316	6	216	216	NUM
fnp-3806	1316	7	.	.	PUNCT
fnp-3806	1316	8	alzheimer	alzheimer	PROPN
fnp-3806	1316	9	a.	a.	PROPN
fnp-3806	1316	10	über	über	PROPN
fnp-3806	1316	11	eine	eine	PROPN
fnp-3806	1316	12	eigenartige	eigenartige	PROPN
fnp-3806	1316	13	erkrankung	erkrankung	PROPN
fnp-3806	1316	14	der	der	ADJ
fnp-3806	1316	15	hirnrinde	hirnrinde	PROPN
fnp-3806	1316	16	.	.	PUNCT
fnp-3806	1317	1	allg	allg	NOUN
fnp-3806	1317	2	z	z	PROPN
fnp-3806	1317	3	psychiat	psychiat	PROPN
fnp-3806	1317	4	1907	1907	NUM
fnp-3806	1317	5	;	;	PUNCT
fnp-3806	1317	6	64	64	NUM
fnp-3806	1317	7	:	:	SYM
fnp-3806	1317	8	146	146	NUM
fnp-3806	1317	9	-	-	SYM
fnp-3806	1317	10	148	148	NUM
fnp-3806	1317	11	.	.	PUNCT
fnp-3806	1318	1	perusini	perusini	PROPN
fnp-3806	1318	2	g.	g.	PROPN
fnp-3806	1318	3	über	über	PROPN
fnp-3806	1318	4	klinisch	klinisch	PROPN
fnp-3806	1318	5	und	und	VERB
fnp-3806	1318	6	histologisch	histologisch	PROPN
fnp-3806	1318	7	eigenartige	eigenartige	PROPN
fnp-3806	1318	8	psychische	psychische	PROPN
fnp-3806	1318	9	erkrankungen	erkrankungen	PROPN
fnp-3806	1318	10	des	des	PROPN
fnp-3806	1318	11	spaateren	spaateren	PROPN
fnp-3806	1318	12	lebensalters	lebensalters	PROPN
fnp-3806	1318	13	.	.	PUNCT
fnp-3806	1319	1	in	in	ADP
fnp-3806	1319	2	:	:	PUNCT
fnp-3806	1319	3	nissl	nissl	PROPN
fnp-3806	1319	4	f	f	PROPN
fnp-3806	1319	5	,	,	PUNCT
fnp-3806	1319	6	alzheimer	alzheimer	PROPN
fnp-3806	1319	7	a	a	DET
fnp-3806	1319	8	(	(	PUNCT
fnp-3806	1319	9	eds	ed	NOUN
fnp-3806	1319	10	)	)	PUNCT
fnp-3806	1319	11	histologische	histologische	NOUN
fnp-3806	1319	12	und	und	PROPN
fnp-3806	1319	13	histopathologische	histopathologische	PROPN
fnp-3806	1319	14	arbeiten	arbeiten	VERB
fnp-3806	1319	15	.	.	PUNCT
fnp-3806	1320	1	fischer	fischer	PROPN
fnp-3806	1320	2	,	,	PUNCT
fnp-3806	1320	3	jena	jena	PROPN
fnp-3806	1320	4	,	,	PUNCT
fnp-3806	1320	5	1910	1910	NUM
fnp-3806	1320	6	kraepelin	kraepelin	PROPN
fnp-3806	1320	7	e.	e.	PROPN
fnp-3806	1320	8	psychiatrie	psychiatrie	PROPN
fnp-3806	1320	9	:	:	PUNCT
fnp-3806	1320	10	ein	ein	PROPN
fnp-3806	1320	11	lehrbuch	lehrbuch	PROPN
fnp-3806	1320	12	für	für	PROPN
fnp-3806	1320	13	studierende	studierende	PROPN
fnp-3806	1320	14	und	und	VERB
fnp-3806	1320	15	ärzte	ärzte	PROPN
fnp-3806	1320	16	.	.	PUNCT
fnp-3806	1321	1	ii	ii	PROPN
fnp-3806	1321	2	.	.	PUNCT
fnp-3806	1321	3	band	band	PROPN
fnp-3806	1321	4	,	,	PUNCT
fnp-3806	1321	5	klinische	klinische	NOUN
fnp-3806	1321	6	psychiatrie	psychiatrie	PROPN
fnp-3806	1321	7	.	.	PUNCT
fnp-3806	1322	1	verlag	verlag	PROPN
fnp-3806	1322	2	johann	johann	PROPN
fnp-3806	1322	3	ambrosius	ambrosius	PROPN
fnp-3806	1322	4	barth	barth	PROPN
fnp-3806	1322	5	,	,	PUNCT
fnp-3806	1322	6	leipzig	leipzig	NOUN
fnp-3806	1322	7	,	,	PUNCT
fnp-3806	1322	8	1910	1910	NUM
fnp-3806	1322	9	,	,	PUNCT
fnp-3806	1322	10	vol.ii	vol.ii	PROPN
fnp-3806	1322	11	.	.	PUNCT
fnp-3806	1323	1	fischer	fischer	PROPN
fnp-3806	1323	2	o.	o.	PROPN
fnp-3806	1323	3	miliare	miliare	PROPN
fnp-3806	1323	4	nekrosen	nekrosen	PROPN
fnp-3806	1323	5	mit	mit	PROPN
fnp-3806	1323	6	drusigen	drusigen	NOUN
fnp-3806	1323	7	wucherungen	wucherungen	NOUN
fnp-3806	1323	8	der	der	PROPN
fnp-3806	1323	9	neurofibrillen	neurofibrillen	PROPN
fnp-3806	1323	10	,	,	PUNCT
fnp-3806	1323	11	eine	eine	PROPN
fnp-3806	1323	12	regelmässige	regelmässige	PROPN
fnp-3806	1323	13	veränderung	veränderung	PROPN
fnp-3806	1323	14	der	der	PROPN
fnp-3806	1323	15	hirnrinde	hirnrinde	NOUN
fnp-3806	1323	16	bei	bei	NOUN
fnp-3806	1323	17	seniler	seniler	NOUN
fnp-3806	1323	18	demenz	demenz	PROPN
fnp-3806	1323	19	.	.	PUNCT
fnp-3806	1324	1	monatsschr	monatsschr	PROPN
fnp-3806	1324	2	psychiat	psychiat	PROPN
fnp-3806	1324	3	neurol	neurol	PROPN
fnp-3806	1324	4	1907	1907	NUM
fnp-3806	1324	5	;	;	PUNCT
fnp-3806	1324	6	22	22	NUM
fnp-3806	1324	7	:	:	PUNCT
fnp-3806	1324	8	361	361	NUM
fnp-3806	1324	9	-	-	SYM
fnp-3806	1324	10	372	372	NUM
fnp-3806	1324	11	.	.	PUNCT
fnp-3806	1325	1	https://doi.org/10.1159/000211873	https://doi.org/10.1159/000211873	PROPN
fnp-3806	1325	2	fischer	fischer	PROPN
fnp-3806	1325	3	o.	o.	PROPN
fnp-3806	1325	4	die	die	VERB
fnp-3806	1325	5	presbyophrene	presbyophrene	PROPN
fnp-3806	1325	6	demenz	demenz	PROPN
fnp-3806	1325	7	,	,	PUNCT
fnp-3806	1325	8	deren	deren	PROPN
fnp-3806	1325	9	anatomische	anatomische	PROPN
fnp-3806	1325	10	grundlage	grundlage	PROPN
fnp-3806	1325	11	und	und	PROPN
fnp-3806	1325	12	klinische	klinische	NOUN
fnp-3806	1325	13	abgrenzung	abgrenzung	NOUN
fnp-3806	1325	14	.	.	PUNCT
fnp-3806	1326	1	z	z	PROPN
fnp-3806	1326	2	ges	ges	PROPN
fnp-3806	1326	3	neurol	neurol	PROPN
fnp-3806	1326	4	psychiat	psychiat	PROPN
fnp-3806	1326	5	1910;3	1910;3	PROPN
fnp-3806	1326	6	:	:	PUNCT
fnp-3806	1326	7	371	371	NUM
fnp-3806	1326	8	-	-	SYM
fnp-3806	1326	9	471	471	NUM
fnp-3806	1326	10	.	.	PUNCT
fnp-3806	1327	1	https://doi.org/10.1007/bf02893605	https://doi.org/10.1007/bf02893605	PROPN
fnp-3806	1328	1	fischer	fischer	PROPN
fnp-3806	1328	2	o.	o.	PROPN
fnp-3806	1328	3	ein	ein	PROPN
fnp-3806	1328	4	weiterer	weiterer	PROPN
fnp-3806	1328	5	beitrag	beitrag	PROPN
fnp-3806	1328	6	zur	zur	PROPN
fnp-3806	1328	7	klinik	klinik	PROPN
fnp-3806	1328	8	und	und	PROPN
fnp-3806	1328	9	pathologie	pathologie	PROPN
fnp-3806	1328	10	der	der	PROPN
fnp-3806	1328	11	presbyophrenen	presbyophrenen	PROPN
fnp-3806	1328	12	demenz	demenz	PROPN
fnp-3806	1328	13	.	.	PUNCT
fnp-3806	1329	1	z	z	PROPN
fnp-3806	1329	2	ges	ges	PROPN
fnp-3806	1329	3	neurol	neurol	PROPN
fnp-3806	1329	4	psychiat	psychiat	PROPN
fnp-3806	1329	5	1912	1912	NUM
fnp-3806	1329	6	;	;	PUNCT
fnp-3806	1329	7	12	12	NUM
fnp-3806	1329	8	:	:	SYM
fnp-3806	1329	9	99	99	NUM
fnp-3806	1329	10	-	-	SYM
fnp-3806	1329	11	135	135	NUM
fnp-3806	1329	12	.	.	PUNCT
fnp-3806	1330	1	https://doi.org/10.1007/bf02866372	https://doi.org/10.1007/bf02866372	VERB
fnp-3806	1330	2	simchowitz	simchowitz	NOUN
fnp-3806	1330	3	t.	t.	PROPN
fnp-3806	1330	4	histologische	histologische	PROPN
fnp-3806	1330	5	studien	studien	PROPN
fnp-3806	1330	6	uber	uber	PROPN
fnp-3806	1330	7	die	die	VERB
fnp-3806	1330	8	senile	senile	ADJ
fnp-3806	1330	9	demenz	demenz	PROPN
fnp-3806	1330	10	.	.	PUNCT
fnp-3806	1331	1	in	in	ADP
fnp-3806	1331	2	:	:	PUNCT
fnp-3806	1331	3	nissl	nissl	PROPN
fnp-3806	1331	4	f	f	PROPN
fnp-3806	1331	5	,	,	PUNCT
fnp-3806	1331	6	alzheimer	alzheimer	PROPN
fnp-3806	1331	7	a	a	DET
fnp-3806	1331	8	(	(	PUNCT
fnp-3806	1331	9	eds	ed	NOUN
fnp-3806	1331	10	)	)	PUNCT
fnp-3806	1331	11	histologische	histologische	NOUN
fnp-3806	1331	12	und	und	VERB
fnp-3806	1331	13	histopathologische	histopathologische	PROPN
fnp-3806	1331	14	arbeiten	arbeiten	PROPN
fnp-3806	1331	15	über	über	PROPN
fnp-3806	1331	16	die	die	X
fnp-3806	1331	17	grosshirnrindem	grosshirnrindem	PROPN
fnp-3806	1331	18	,	,	PUNCT
fnp-3806	1331	19	vol	vol	NOUN
fnp-3806	1331	20	.	.	PROPN
fnp-3806	1331	21	4	4	NUM
fnp-3806	1331	22	.	.	X
fnp-3806	1331	23	fischer	fischer	PROPN
fnp-3806	1331	24	,	,	PUNCT
fnp-3806	1331	25	jena	jena	PROPN
fnp-3806	1331	26	,	,	PUNCT
fnp-3806	1331	27	1911	1911	NUM
fnp-3806	1331	28	;	;	PUNCT
fnp-3806	1331	29	pp	pp	ADP
fnp-3806	1331	30	267	267	NUM
fnp-3806	1331	31	-	-	SYM
fnp-3806	1331	32	444	444	NUM
fnp-3806	1331	33	.	.	PUNCT
fnp-3806	1332	1	goedert	goedert	PROPN
fnp-3806	1332	2	m.	m.	PROPN
fnp-3806	1332	3	oskar	oskar	PROPN
fnp-3806	1332	4	fischer	fischer	PROPN
fnp-3806	1332	5	and	and	CCONJ
fnp-3806	1332	6	the	the	DET
fnp-3806	1332	7	study	study	NOUN
fnp-3806	1332	8	of	of	ADP
fnp-3806	1332	9	dementia	dementia	NOUN
fnp-3806	1332	10	.	.	PUNCT
fnp-3806	1333	1	brain	brain	NOUN
fnp-3806	1333	2	2009	2009	NUM
fnp-3806	1333	3	;	;	PUNCT
fnp-3806	1333	4	132;1102	132;1102	NUM
fnp-3806	1333	5	-	-	SYM
fnp-3806	1333	6	1111	1111	NUM
fnp-3806	1333	7	.	.	PUNCT
fnp-3806	1334	1	https://doi.org/10.1093/brain/awn256	https://doi.org/10.1093/brain/awn256	PROPN
fnp-3806	1334	2	bielschowsky	bielschowsky	PROPN
fnp-3806	1334	3	m.	m.	NOUN
fnp-3806	1334	4	zur	zur	PROPN
fnp-3806	1334	5	kenntnis	kenntnis	PROPN
fnp-3806	1334	6	der	der	PROPN
fnp-3806	1334	7	alzheimerschen	alzheimerschen	PROPN
fnp-3806	1334	8	krankheit	krankheit	PROPN
fnp-3806	1334	9	(	(	PUNCT
fnp-3806	1334	10	präsenilen	präsenilen	VERB
fnp-3806	1334	11	demenz	demenz	ADP
fnp-3806	1334	12	mit	mit	NOUN
fnp-3806	1334	13	herdsymptomen	herdsymptoman	NOUN
fnp-3806	1334	14	)	)	PUNCT
fnp-3806	1334	15	.	.	PUNCT
fnp-3806	1335	1	j	j	PROPN
fnp-3806	1335	2	psychol	psychol	PROPN
fnp-3806	1335	3	neurol	neurol	PROPN
fnp-3806	1335	4	1911;18:1	1911;18:1	PROPN
fnp-3806	1335	5	-	-	SYM
fnp-3806	1335	6	20	20	NUM
fnp-3806	1335	7	.	.	PUNCT
fnp-3806	1336	1	karenberg	karenberg	PROPN
fnp-3806	1336	2	a.	a.	PROPN
fnp-3806	1336	3	early	early	PROPN
fnp-3806	1336	4	history	history	NOUN
fnp-3806	1336	5	of	of	ADP
fnp-3806	1336	6	pick	pick	PROPN
fnp-3806	1336	7	's	's	PART
fnp-3806	1336	8	disease	disease	NOUN
fnp-3806	1336	9	.	.	PUNCT
fnp-3806	1337	1	fortschr	fortschr	PROPN
fnp-3806	1337	2	neurol	neurol	PROPN
fnp-3806	1337	3	psychiatr	psychiatr	ADJ
fnp-3806	1337	4	2001;69	2001;69	NUM
fnp-3806	1337	5	:	:	PUNCT
fnp-3806	1337	6	545	545	NUM
fnp-3806	1337	7	-	-	SYM
fnp-3806	1337	8	50	50	NUM
fnp-3806	1337	9	.	.	PUNCT
fnp-3806	1338	1	https://doi.org/10.1055/s-2001-18378	https://doi.org/10.1055/s-2001-18378	PROPN
fnp-3806	1338	2	delay	delay	PROPN
fnp-3806	1338	3	j	j	PROPN
fnp-3806	1338	4	,	,	PUNCT
fnp-3806	1338	5	brion	brion	PROPN
fnp-3806	1338	6	s.	s.	PROPN
fnp-3806	1338	7	les	les	PROPN
fnp-3806	1338	8	démences	démence	VERB
fnp-3806	1338	9	tardives	tardive	NOUN
fnp-3806	1338	10	.	.	PUNCT
fnp-3806	1339	1	masson	masson	PROPN
fnp-3806	1339	2	,	,	PUNCT
fnp-3806	1339	3	paris	paris	PROPN
fnp-3806	1339	4	,	,	PUNCT
fnp-3806	1339	5	1962	1962	NUM
fnp-3806	1339	6	jervis	jervis	PROPN
fnp-3806	1339	7	ga	ga	PROPN
fnp-3806	1339	8	,	,	PUNCT
fnp-3806	1339	9	soltz	soltz	PROPN
fnp-3806	1339	10	se	se	PROPN
fnp-3806	1339	11	.	.	PROPN
fnp-3806	1340	1	alzheimer	alzheimer	PROPN
fnp-3806	1340	2	’s	’s	PART
fnp-3806	1340	3	disease	disease	NOUN
fnp-3806	1340	4	:	:	PUNCT
fnp-3806	1340	5	the	the	DET
fnp-3806	1340	6	so	so	ADV
fnp-3806	1340	7	-	-	PUNCT
fnp-3806	1340	8	called	call	VERB
fnp-3806	1340	9	juvenile	juvenile	ADJ
fnp-3806	1340	10	form	form	NOUN
fnp-3806	1340	11	.	.	PUNCT
fnp-3806	1340	12	am	be	AUX
fnp-3806	1340	13	j	j	PROPN
fnp-3806	1340	14	psychiatr	psychiatr	ADJ
fnp-3806	1340	15	1936	1936	NUM
fnp-3806	1340	16	;	;	PUNCT
fnp-3806	1340	17	93	93	NUM
fnp-3806	1340	18	:	:	SYM
fnp-3806	1340	19	39	39	NUM
fnp-3806	1340	20	-	-	SYM
fnp-3806	1340	21	56	56	NUM
fnp-3806	1340	22	.	.	PUNCT
fnp-3806	1341	1	https://doi.org/10.1176/ajp.93.1.39	https://doi.org/10.1176/ajp.93.1.39	PROPN
fnp-3806	1341	2	blessed	bless	VERB
fnp-3806	1341	3	g	g	PROPN
fnp-3806	1341	4	,	,	PUNCT
fnp-3806	1341	5	tomlinson	tomlinson	PROPN
fnp-3806	1341	6	b	b	PROPN
fnp-3806	1341	7	,	,	PUNCT
fnp-3806	1341	8	roth	roth	PROPN
fnp-3806	1341	9	m.	m.	NOUN
fnp-3806	1341	10	the	the	DET
fnp-3806	1341	11	association	association	NOUN
fnp-3806	1341	12	between	between	ADP
fnp-3806	1341	13	quantitative	quantitative	ADJ
fnp-3806	1341	14	measures	measure	NOUN
fnp-3806	1341	15	of	of	ADP
fnp-3806	1341	16	dementia	dementia	NOUN
fnp-3806	1341	17	and	and	CCONJ
fnp-3806	1341	18	of	of	ADP
fnp-3806	1341	19	senile	senile	ADJ
fnp-3806	1341	20	changes	change	NOUN
fnp-3806	1341	21	in	in	ADP
fnp-3806	1341	22	the	the	DET
fnp-3806	1341	23	cerebral	cerebral	ADJ
fnp-3806	1341	24	grey	grey	ADJ
fnp-3806	1341	25	matter	matter	NOUN
fnp-3806	1341	26	of	of	ADP
fnp-3806	1341	27	elderly	elderly	ADJ
fnp-3806	1341	28	subjects	subject	NOUN
fnp-3806	1341	29	.	.	PUNCT
fnp-3806	1342	1	br	br	PROPN
fnp-3806	1342	2	j	j	PROPN
fnp-3806	1342	3	psych	psych	PROPN
fnp-3806	1342	4	1968;114	1968;114	NOUN
fnp-3806	1342	5	:	:	PUNCT
fnp-3806	1342	6	797	797	NUM
fnp-3806	1342	7	-	-	SYM
fnp-3806	1342	8	811	811	NUM
fnp-3806	1342	9	.	.	PUNCT
fnp-3806	1343	1	https://doi.org/10.1192/bjp.114.512.797	https://doi.org/10.1192/bjp.114.512.797	PROPN
fnp-3806	1343	2	katzman	katzman	PROPN
fnp-3806	1343	3	r.	r.	PROPN
fnp-3806	1343	4	editorial	editorial	PROPN
fnp-3806	1343	5	:	:	PUNCT
fnp-3806	1343	6	the	the	DET
fnp-3806	1343	7	prevalence	prevalence	NOUN
fnp-3806	1343	8	and	and	CCONJ
fnp-3806	1343	9	malignancy	malignancy	NOUN
fnp-3806	1343	10	of	of	ADP
fnp-3806	1343	11	alzheimer	alzheimer	PROPN
fnp-3806	1343	12	disease	disease	PROPN
fnp-3806	1343	13	:	:	PUNCT
fnp-3806	1343	14	a	a	DET
fnp-3806	1343	15	major	major	ADJ
fnp-3806	1343	16	killer	killer	NOUN
fnp-3806	1343	17	.	.	PUNCT
fnp-3806	1344	1	arch	arch	ADJ
fnp-3806	1344	2	neurol	neurol	NOUN
fnp-3806	1344	3	1976	1976	NUM
fnp-3806	1344	4	;	;	PUNCT
fnp-3806	1344	5	33:217	33:217	NUM
fnp-3806	1344	6	-	-	SYM
fnp-3806	1344	7	218	218	NUM
fnp-3806	1344	8	.	.	PUNCT
fnp-3806	1345	1	https://doi.org/10.1001/archneur.1976.00500040001001	https://doi.org/10.1001/archneur.1976.00500040001001	PROPN
fnp-3806	1345	2	tomlinson	tomlinson	PROPN
fnp-3806	1345	3	be	be	VERB
fnp-3806	1345	4	,	,	PUNCT
fnp-3806	1345	5	blessed	bless	VERB
fnp-3806	1345	6	g	g	PROPN
fnp-3806	1345	7	,	,	PUNCT
fnp-3806	1345	8	roth	roth	PROPN
fnp-3806	1345	9	m.	m.	NOUN
fnp-3806	1345	10	observations	observation	NOUN
fnp-3806	1345	11	on	on	ADP
fnp-3806	1345	12	the	the	DET
fnp-3806	1345	13	brains	brain	NOUN
fnp-3806	1345	14	of	of	ADP
fnp-3806	1345	15	demented	demented	ADJ
fnp-3806	1345	16	old	old	ADJ
fnp-3806	1345	17	people	people	NOUN
fnp-3806	1345	18	.	.	PUNCT
fnp-3806	1346	1	j	j	PROPN
fnp-3806	1346	2	neurol	neurol	PROPN
fnp-3806	1346	3	sci	sci	PROPN
fnp-3806	1346	4	1970	1970	NUM
fnp-3806	1346	5	;	;	PUNCT
fnp-3806	1346	6	11:205	11:205	NUM
fnp-3806	1346	7	-	-	SYM
fnp-3806	1346	8	242	242	NUM
fnp-3806	1346	9	.	.	PUNCT
fnp-3806	1347	1	https://doi.org/10.1016/0022-510x(70)90063-8	https://doi.org/10.1016/0022-510x(70)90063-8	ADP
fnp-3806	1347	2	terry	terry	PROPN
fnp-3806	1347	3	rd	rd	PROPN
fnp-3806	1347	4	,	,	PUNCT
fnp-3806	1347	5	katzman	katzman	PROPN
fnp-3806	1347	6	r.	r.	PROPN
fnp-3806	1347	7	senile	senile	PROPN
fnp-3806	1347	8	dementia	dementia	NOUN
fnp-3806	1347	9	of	of	ADP
fnp-3806	1347	10	the	the	DET
fnp-3806	1347	11	alzheimer	alzheimer	PROPN
fnp-3806	1347	12	type	type	NOUN
fnp-3806	1347	13	.	.	PUNCT
fnp-3806	1348	1	ann	ann	PROPN
fnp-3806	1348	2	neurol	neurol	PROPN
fnp-3806	1348	3	1983;14	1983;14	NUM
fnp-3806	1348	4	:	:	PUNCT
fnp-3806	1348	5	497	497	NUM
fnp-3806	1348	6	-	-	SYM
fnp-3806	1348	7	506	506	NUM
fnp-3806	1348	8	.	.	PUNCT
fnp-3806	1349	1	https://doi.org/10.1002/ana.410140502	https://doi.org/10.1002/ana.410140502	PROPN
fnp-3806	1349	2	mckhann	mckhann	PROPN
fnp-3806	1349	3	gm	gm	PROPN
fnp-3806	1349	4	,	,	PUNCT
fnp-3806	1349	5	knopman	knopman	NOUN
fnp-3806	1349	6	ds	ds	PROPN
fnp-3806	1349	7	,	,	PUNCT
fnp-3806	1349	8	chertkow	chertkow	VERB
fnp-3806	1349	9	h	h	NOUN
fnp-3806	1349	10	,	,	PUNCT
fnp-3806	1349	11	et	et	PROPN
fnp-3806	1349	12	al	al	PROPN
fnp-3806	1349	13	.	.	PUNCT
fnp-3806	1350	1	the	the	DET
fnp-3806	1350	2	diagnosis	diagnosis	NOUN
fnp-3806	1350	3	of	of	ADP
fnp-3806	1350	4	dementia	dementia	NOUN
fnp-3806	1350	5	due	due	ADP
fnp-3806	1350	6	to	to	ADP
fnp-3806	1350	7	alzheimer	alzheimer	PROPN
fnp-3806	1350	8	's	's	PART
fnp-3806	1350	9	disease	disease	NOUN
fnp-3806	1350	10	:	:	PUNCT
fnp-3806	1350	11	recommendations	recommendation	NOUN
fnp-3806	1350	12	from	from	ADP
fnp-3806	1350	13	the	the	DET
fnp-3806	1350	14	national	national	PROPN
fnp-3806	1350	15	institute	institute	PROPN
fnp-3806	1350	16	on	on	ADP
fnp-3806	1350	17	aging	age	VERB
fnp-3806	1350	18	-	-	PUNCT
fnp-3806	1350	19	alzheimer	alzheimer	NOUN
fnp-3806	1350	20	's	's	PART
fnp-3806	1350	21	association	association	NOUN
fnp-3806	1350	22	workgroups	workgroup	NOUN
fnp-3806	1350	23	on	on	ADP
fnp-3806	1350	24	diagnostic	diagnostic	ADJ
fnp-3806	1350	25	guidelines	guideline	NOUN
fnp-3806	1350	26	for	for	ADP
fnp-3806	1350	27	alzheimer	alzheimer	PROPN
fnp-3806	1350	28	's	's	PART
fnp-3806	1350	29	disease	disease	NOUN
fnp-3806	1350	30	.	.	PUNCT
fnp-3806	1351	1	alzheimers	alzheimers	PROPN
fnp-3806	1351	2	dement	dement	PROPN
fnp-3806	1351	3	2011;7:263	2011;7:263	PROPN
fnp-3806	1351	4	-	-	SYM
fnp-3806	1351	5	269	269	NUM
fnp-3806	1351	6	.	.	PUNCT
fnp-3806	1352	1	https://doi.org/10.1016/j.jalz.2011.03.005	https://doi.org/10.1016/j.jalz.2011.03.005	PROPN
fnp-3806	1352	2	crystal	crystal	PROPN
fnp-3806	1352	3	h	h	NOUN
fnp-3806	1352	4	,	,	PUNCT
fnp-3806	1352	5	dickson	dickson	PROPN
fnp-3806	1352	6	d	d	PROPN
fnp-3806	1352	7	,	,	PUNCT
fnp-3806	1352	8	fuld	fuld	PROPN
fnp-3806	1352	9	p	p	PROPN
fnp-3806	1352	10	,	,	PUNCT
fnp-3806	1352	11	et	et	PROPN
fnp-3806	1352	12	al	al	PROPN
fnp-3806	1352	13	.	.	PUNCT
fnp-3806	1353	1	clinico	clinico	ADJ
fnp-3806	1353	2	-	-	PUNCT
fnp-3806	1353	3	pathologic	pathologic	ADJ
fnp-3806	1353	4	studies	study	NOUN
fnp-3806	1353	5	in	in	ADP
fnp-3806	1353	6	dementia	dementia	PROPN
fnp-3806	1353	7	:	:	PUNCT
fnp-3806	1353	8	nondemented	nondemente	VERB
fnp-3806	1353	9	subjects	subject	NOUN
fnp-3806	1353	10	with	with	ADP
fnp-3806	1353	11	pathologically	pathologically	ADV
fnp-3806	1353	12	confirmed	confirm	VERB
fnp-3806	1353	13	alzheimer	alzheimer	PROPN
fnp-3806	1353	14	's	's	PART
fnp-3806	1353	15	disease	disease	NOUN
fnp-3806	1353	16	neurology	neurology	NOUN
fnp-3806	1353	17	1988;38:1682	1988;38:1682	NOUN
fnp-3806	1353	18	-	-	PUNCT
fnp-3806	1353	19	1687	1687	NUM
fnp-3806	1353	20	.	.	PUNCT
fnp-3806	1354	1	https://doi.org/10.1212/wnl.38.11.1682	https://doi.org/10.1212/wnl.38.11.1682	NOUN
fnp-3806	1354	2	price	price	NOUN
fnp-3806	1354	3	jl	jl	PROPN
fnp-3806	1354	4	,	,	PUNCT
fnp-3806	1354	5	davis	davis	PROPN
fnp-3806	1354	6	pb	pb	PROPN
fnp-3806	1354	7	,	,	PUNCT
fnp-3806	1354	8	morris	morris	PROPN
fnp-3806	1354	9	jc	jc	PROPN
fnp-3806	1354	10	,	,	PUNCT
fnp-3806	1354	11	et	et	PROPN
fnp-3806	1354	12	al	al	PROPN
fnp-3806	1354	13	.	.	PUNCT
fnp-3806	1355	1	the	the	DET
fnp-3806	1355	2	distribution	distribution	NOUN
fnp-3806	1355	3	of	of	ADP
fnp-3806	1355	4	tangles	tangle	NOUN
fnp-3806	1355	5	,	,	PUNCT
fnp-3806	1355	6	plaques	plaque	NOUN
fnp-3806	1355	7	and	and	CCONJ
fnp-3806	1355	8	related	relate	VERB
fnp-3806	1355	9	immunohistochemical	immunohistochemical	ADJ
fnp-3806	1355	10	markers	marker	NOUN
fnp-3806	1355	11	in	in	ADP
fnp-3806	1355	12	healthy	healthy	ADJ
fnp-3806	1355	13	aging	aging	NOUN
fnp-3806	1355	14	and	and	CCONJ
fnp-3806	1355	15	alzheimer	alzheimer	NOUN
fnp-3806	1355	16	's	's	PART
fnp-3806	1355	17	disease	disease	NOUN
fnp-3806	1355	18	.	.	PUNCT
fnp-3806	1356	1	neurobiol	neurobiol	PROPN
fnp-3806	1356	2	aging	age	VERB
fnp-3806	1356	3	1991;12:295	1991;12:295	NUM
fnp-3806	1356	4	-	-	SYM
fnp-3806	1356	5	312	312	NUM
fnp-3806	1356	6	.	.	PUNCT
fnp-3806	1357	1	https://doi.org/10.1016/0197-4580(91)90006-6	https://doi.org/10.1016/0197-4580(91)90006-6	ADJ
fnp-3806	1357	2	rriagada	rriagada	PROPN
fnp-3806	1357	3	pv	pv	PROPN
fnp-3806	1357	4	,	,	PUNCT
fnp-3806	1357	5	marzloff	marzloff	PROPN
fnp-3806	1357	6	k	k	PROPN
fnp-3806	1357	7	,	,	PUNCT
fnp-3806	1357	8	hyman	hyman	PROPN
fnp-3806	1357	9	bt	bt	PROPN
fnp-3806	1357	10	.	.	PUNCT
fnp-3806	1357	11	distribution	distribution	NOUN
fnp-3806	1357	12	of	of	ADP
fnp-3806	1357	13	alzheimer	alzheimer	ADJ
fnp-3806	1357	14	-	-	PUNCT
fnp-3806	1357	15	type	type	NOUN
fnp-3806	1357	16	pathologic	pathologic	ADJ
fnp-3806	1357	17	changes	change	NOUN
fnp-3806	1357	18	in	in	ADP
fnp-3806	1357	19	nondemented	nondemented	ADJ
fnp-3806	1357	20	elderly	elderly	ADJ
fnp-3806	1357	21	individuals	individual	NOUN
fnp-3806	1357	22	matches	match	VERB
fnp-3806	1357	23	the	the	DET
fnp-3806	1357	24	pattern	pattern	NOUN
fnp-3806	1357	25	in	in	ADP
fnp-3806	1357	26	alzheimer	alzheimer	PROPN
fnp-3806	1357	27	's	's	PART
fnp-3806	1357	28	disease	disease	NOUN
fnp-3806	1357	29	.	.	PUNCT
fnp-3806	1358	1	neurology	neurology	NOUN
fnp-3806	1358	2	1992;42:1681	1992;42:1681	PROPN
fnp-3806	1358	3	-	-	PUNCT
fnp-3806	1358	4	1688	1688	NUM
fnp-3806	1358	5	.	.	PUNCT
fnp-3806	1359	1	https://doi.org/10.1212/wnl.42.9.1681	https://doi.org/10.1212/wnl.42.9.1681	ADP
fnp-3806	1359	2	bouras	bouras	NUM
fnp-3806	1359	3	c	c	NOUN
fnp-3806	1359	4	,	,	PUNCT
fnp-3806	1359	5	hof	hof	PROPN
fnp-3806	1359	6	pr	pr	PROPN
fnp-3806	1359	7	,	,	PUNCT
fnp-3806	1359	8	morrison	morrison	PROPN
fnp-3806	1359	9	jh	jh	PROPN
fnp-3806	1359	10	.	.	PUNCT
fnp-3806	1360	1	neurofibrillary	neurofibrillary	PROPN
fnp-3806	1360	2	tangle	tangle	NOUN
fnp-3806	1360	3	densities	density	NOUN
fnp-3806	1360	4	in	in	ADP
fnp-3806	1360	5	the	the	DET
fnp-3806	1360	6	hippocampal	hippocampal	ADJ
fnp-3806	1360	7	formation	formation	NOUN
fnp-3806	1360	8	in	in	ADP
fnp-3806	1360	9	a	a	DET
fnp-3806	1360	10	non	non	ADJ
fnp-3806	1360	11	-	-	ADJ
fnp-3806	1360	12	demented	demented	ADJ
fnp-3806	1360	13	population	population	NOUN
fnp-3806	1360	14	define	define	VERB
fnp-3806	1360	15	subgroups	subgroup	NOUN
fnp-3806	1360	16	of	of	ADP
fnp-3806	1360	17	patients	patient	NOUN
fnp-3806	1360	18	with	with	ADP
fnp-3806	1360	19	differential	differential	ADJ
fnp-3806	1360	20	early	early	ADJ
fnp-3806	1360	21	pathologic	pathologic	ADJ
fnp-3806	1360	22	changes	change	NOUN
fnp-3806	1360	23	.	.	PUNCT
fnp-3806	1361	1	neurosci	neurosci	PROPN
fnp-3806	1361	2	lett	lett	PROPN
fnp-3806	1361	3	1993;153:131	1993;153:131	NUM
fnp-3806	1361	4	-	-	SYM
fnp-3806	1361	5	135	135	NUM
fnp-3806	1361	6	.	.	PUNCT
fnp-3806	1362	1	https://doi.org/10.1016/0304-3940(93)90305-5	https://doi.org/10.1016/0304-3940(93)90305-5	NOUN
fnp-3806	1362	2	bouras	bouras	NUM
fnp-3806	1362	3	c	c	NOUN
fnp-3806	1362	4	,	,	PUNCT
fnp-3806	1362	5	hof	hof	PROPN
fnp-3806	1362	6	pr	pr	PROPN
fnp-3806	1362	7	,	,	PUNCT
fnp-3806	1362	8	giannakopoulos	giannakopoulos	PROPN
fnp-3806	1362	9	p	p	PROPN
fnp-3806	1362	10	,	,	PUNCT
fnp-3806	1362	11	et	et	PROPN
fnp-3806	1362	12	al	al	PROPN
fnp-3806	1362	13	.	.	PUNCT
fnp-3806	1363	1	regional	regional	ADJ
fnp-3806	1363	2	distribution	distribution	NOUN
fnp-3806	1363	3	of	of	ADP
fnp-3806	1363	4	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1363	5	tangles	tangle	NOUN
fnp-3806	1363	6	and	and	CCONJ
fnp-3806	1363	7	senile	senile	ADJ
fnp-3806	1363	8	plaques	plaque	NOUN
fnp-3806	1363	9	in	in	ADP
fnp-3806	1363	10	the	the	DET
fnp-3806	1363	11	cerebral	cerebral	ADJ
fnp-3806	1363	12	cortex	cortex	NOUN
fnp-3806	1363	13	of	of	ADP
fnp-3806	1363	14	elderly	elderly	ADJ
fnp-3806	1363	15	patients	patient	NOUN
fnp-3806	1363	16	:	:	PUNCT
fnp-3806	1363	17	a	a	DET
fnp-3806	1363	18	quantitative	quantitative	ADJ
fnp-3806	1363	19	evaluation	evaluation	NOUN
fnp-3806	1363	20	of	of	ADP
fnp-3806	1363	21	a	a	DET
fnp-3806	1363	22	one	one	NUM
fnp-3806	1363	23	-	-	PUNCT
fnp-3806	1363	24	year	year	NOUN
fnp-3806	1363	25	autopsy	autopsy	ADJ
fnp-3806	1363	26	population	population	NOUN
fnp-3806	1363	27	from	from	ADP
fnp-3806	1363	28	a	a	DET
fnp-3806	1363	29	geriatric	geriatric	ADJ
fnp-3806	1363	30	hospital	hospital	NOUN
fnp-3806	1363	31	.	.	PUNCT
fnp-3806	1364	1	cereb	cereb	PROPN
fnp-3806	1364	2	cortex	cortex	NOUN
fnp-3806	1364	3	1994;4:138	1994;4:138	PROPN
fnp-3806	1364	4	-	-	SYM
fnp-3806	1364	5	150	150	NUM
fnp-3806	1364	6	.	.	PUNCT
fnp-3806	1365	1	https://doi.org/10.1093/cercor/4.2.138	https://doi.org/10.1093/cercor/4.2.138	PROPN
fnp-3806	1365	2	knopman	knopman	PROPN
fnp-3806	1365	3	ds	ds	PROPN
fnp-3806	1365	4	,	,	PUNCT
fnp-3806	1365	5	parisi	parisi	PROPN
fnp-3806	1365	6	je	je	PROPN
fnp-3806	1365	7	,	,	PUNCT
fnp-3806	1365	8	salviati	salviati	PROPN
fnp-3806	1365	9	a	a	PRON
fnp-3806	1365	10	,	,	PUNCT
fnp-3806	1365	11	floriach	floriach	PROPN
fnp-3806	1365	12	-	-	PUNCT
fnp-3806	1365	13	robert	robert	PROPN
fnp-3806	1365	14	m	m	PROPN
fnp-3806	1365	15	,	,	PUNCT
fnp-3806	1365	16	boeve	boeve	NOUN
fnp-3806	1365	17	bf	bf	NOUN
fnp-3806	1365	18	,	,	PUNCT
fnp-3806	1365	19	ivnik	ivnik	PROPN
fnp-3806	1365	20	rj	rj	PROPN
fnp-3806	1365	21	,	,	PUNCT
fnp-3806	1365	22	et	et	PROPN
fnp-3806	1365	23	al	al	PROPN
fnp-3806	1365	24	.	.	PROPN
fnp-3806	1365	25	neuropathology	neuropathology	NOUN
fnp-3806	1365	26	of	of	ADP
fnp-3806	1365	27	cognitively	cognitively	ADV
fnp-3806	1365	28	normal	normal	ADJ
fnp-3806	1365	29	elderly	elderly	ADJ
fnp-3806	1365	30	.	.	PUNCT
fnp-3806	1366	1	j	j	PROPN
fnp-3806	1366	2	neuropathol	neuropathol	PROPN
fnp-3806	1366	3	exp	exp	PROPN
fnp-3806	1366	4	neurol	neurol	PROPN
fnp-3806	1366	5	2003;62:1087	2003;62:1087	NUM
fnp-3806	1366	6	-	-	SYM
fnp-3806	1366	7	1095	1095	NUM
fnp-3806	1366	8	.	.	PUNCT
fnp-3806	1367	1	https://doi.org/10.1093/jnen/62.11.1087	https://doi.org/10.1093/jnen/62.11.1087	PROPN
fnp-3806	1367	2	bennett	bennett	PROPN
fnp-3806	1367	3	da	da	PROPN
fnp-3806	1367	4	,	,	PUNCT
fnp-3806	1367	5	schneider	schneider	PROPN
fnp-3806	1367	6	ja	ja	PROPN
fnp-3806	1367	7	,	,	PUNCT
fnp-3806	1367	8	arvanitakis	arvanitakis	PROPN
fnp-3806	1367	9	z	z	PROPN
fnp-3806	1367	10	,	,	PUNCT
fnp-3806	1367	11	et	et	PROPN
fnp-3806	1367	12	al	al	PROPN
fnp-3806	1367	13	.	.	PROPN
fnp-3806	1367	14	neuropathology	neuropathology	NOUN
fnp-3806	1367	15	of	of	ADP
fnp-3806	1367	16	older	old	ADJ
fnp-3806	1367	17	persons	person	NOUN
fnp-3806	1367	18	without	without	ADP
fnp-3806	1367	19	cognitive	cognitive	ADJ
fnp-3806	1367	20	impairment	impairment	NOUN
fnp-3806	1367	21	from	from	ADP
fnp-3806	1367	22	two	two	NUM
fnp-3806	1367	23	community	community	NOUN
fnp-3806	1367	24	-	-	PUNCT
fnp-3806	1367	25	based	base	VERB
fnp-3806	1367	26	studies	study	NOUN
fnp-3806	1367	27	.	.	PUNCT
fnp-3806	1368	1	neurology	neurology	NOUN
fnp-3806	1368	2	2006;66:1837	2006;66:1837	PROPN
fnp-3806	1368	3	-	-	SYM
fnp-3806	1368	4	1844	1844	NUM
fnp-3806	1368	5	.	.	PUNCT
fnp-3806	1369	1	https://doi.org/10.1212/01.wnl.0000219668.47116.e6	https://doi.org/10.1212/01.wnl.0000219668.47116.e6	PROPN
fnp-3806	1369	2	khachaturian	khachaturian	PROPN
fnp-3806	1369	3	zs	zs	PROPN
fnp-3806	1369	4	.	.	PUNCT
fnp-3806	1369	5	diagnosis	diagnosis	NOUN
fnp-3806	1369	6	of	of	ADP
fnp-3806	1369	7	alzheimer	alzheimer	PROPN
fnp-3806	1369	8	’s	’s	PART
fnp-3806	1369	9	disease	disease	NOUN
fnp-3806	1369	10	.	.	PUNCT
fnp-3806	1370	1	arch	arch	ADJ
fnp-3806	1370	2	neurol	neurol	PROPN
fnp-3806	1370	3	1985;42	1985;42	ADJ
fnp-3806	1370	4	:	:	PUNCT
fnp-3806	1370	5	1097–1105	1097–1105	NUM
fnp-3806	1370	6	.	.	PUNCT
fnp-3806	1371	1	https://doi.org/10.1001/archneur.1985.04060100083029	https://doi.org/10.1001/archneur.1985.04060100083029	PROPN
fnp-3806	1371	2	wisniewski	wisniewski	PROPN
fnp-3806	1371	3	hm	hm	PROPN
fnp-3806	1371	4	,	,	PUNCT
fnp-3806	1371	5	robe	robe	NOUN
fnp-3806	1371	6	a	a	PRON
fnp-3806	1371	7	,	,	PUNCT
fnp-3806	1371	8	zigmanw	zigmanw	PROPN
fnp-3806	1371	9	,	,	PUNCT
fnp-3806	1371	10	et	et	PROPN
fnp-3806	1371	11	al	al	PROPN
fnp-3806	1371	12	.	.	PUNCT
fnp-3806	1372	1	neuropathological	neuropathological	ADJ
fnp-3806	1372	2	diagnosis	diagnosis	NOUN
fnp-3806	1372	3	of	of	ADP
fnp-3806	1372	4	alzheimer	alzheimer	PROPN
fnp-3806	1372	5	disease	disease	PROPN
fnp-3806	1372	6	.	.	PUNCT
fnp-3806	1373	1	j	j	PROPN
fnp-3806	1373	2	neuropathol	neuropathol	PROPN
fnp-3806	1373	3	exp	exp	PROPN
fnp-3806	1373	4	neurol	neurol	PROPN
fnp-3806	1373	5	1989;48	1989;48	NUM
fnp-3806	1373	6	:	:	PUNCT
fnp-3806	1373	7	606	606	NUM
fnp-3806	1373	8	-	-	SYM
fnp-3806	1373	9	609	609	NUM
fnp-3806	1373	10	.	.	PUNCT
fnp-3806	1374	1	https://doi.org/10.1097/00005072-198911000-00001	https://doi.org/10.1097/00005072-198911000-00001	PROPN
fnp-3806	1374	2	mirra	mirra	PROPN
fnp-3806	1374	3	ss	ss	PROPN
fnp-3806	1374	4	,	,	PUNCT
fnp-3806	1374	5	heyman	heyman	PROPN
fnp-3806	1374	6	a	a	PROPN
fnp-3806	1374	7	,	,	PUNCT
fnp-3806	1374	8	mckeel	mckeel	NOUN
fnp-3806	1374	9	d	d	PROPN
fnp-3806	1374	10	,	,	PUNCT
fnp-3806	1374	11	et	et	PROPN
fnp-3806	1374	12	al	al	PROPN
fnp-3806	1374	13	.	.	PUNCT
fnp-3806	1375	1	the	the	DET
fnp-3806	1375	2	consortium	consortium	NOUN
fnp-3806	1375	3	to	to	PART
fnp-3806	1375	4	establish	establish	VERB
fnp-3806	1375	5	a	a	DET
fnp-3806	1375	6	registry	registry	NOUN
fnp-3806	1375	7	for	for	ADP
fnp-3806	1375	8	alzheimer	alzheimer	PROPN
fnp-3806	1375	9	’s	’s	PART
fnp-3806	1375	10	disease	disease	NOUN
fnp-3806	1375	11	(	(	PUNCT
fnp-3806	1375	12	cerad	cerad	PROPN
fnp-3806	1375	13	)	)	PUNCT
fnp-3806	1375	14	.	.	PUNCT
fnp-3806	1376	1	part	part	PROPN
fnp-3806	1376	2	ii	ii	PROPN
fnp-3806	1376	3	.	.	PUNCT
fnp-3806	1377	1	standardization	standardization	NOUN
fnp-3806	1377	2	of	of	ADP
fnp-3806	1377	3	the	the	DET
fnp-3806	1377	4	neuropathologic	neuropathologic	ADJ
fnp-3806	1377	5	assessment	assessment	NOUN
fnp-3806	1377	6	of	of	ADP
fnp-3806	1377	7	alzheimer	alzheimer	PROPN
fnp-3806	1377	8	’s	’s	PART
fnp-3806	1377	9	disease	disease	NOUN
fnp-3806	1377	10	.	.	PUNCT
fnp-3806	1378	1	neurology	neurology	NOUN
fnp-3806	1378	2	1991;41:479	1991;41:479	PROPN
fnp-3806	1378	3	-	-	PUNCT
fnp-3806	1378	4	486	486	NUM
fnp-3806	1378	5	.	.	PUNCT
fnp-3806	1379	1	https://doi.org/10.1212/wnl.41.4.479	https://doi.org/10.1212/wnl.41.4.479	PROPN
fnp-3806	1379	2	mirra	mirra	PROPN
fnp-3806	1379	3	ss	ss	PROPN
fnp-3806	1379	4	,	,	PUNCT
fnp-3806	1379	5	hart	hart	PROPN
fnp-3806	1379	6	mn	mn	PROPN
fnp-3806	1379	7	,	,	PUNCT
fnp-3806	1379	8	terry	terry	PROPN
fnp-3806	1379	9	rd	rd	PROPN
fnp-3806	1379	10	.	.	PUNCT
fnp-3806	1380	1	making	make	VERB
fnp-3806	1380	2	the	the	DET
fnp-3806	1380	3	diagnosis	diagnosis	NOUN
fnp-3806	1380	4	of	of	ADP
fnp-3806	1380	5	alzheimer	alzheimer	PROPN
fnp-3806	1380	6	's	's	PART
fnp-3806	1380	7	disease	disease	NOUN
fnp-3806	1380	8	.	.	PUNCT
fnp-3806	1381	1	a	a	DET
fnp-3806	1381	2	primer	primer	NOUN
fnp-3806	1381	3	for	for	ADP
fnp-3806	1381	4	practicing	practice	VERB
fnp-3806	1381	5	pathologists	pathologist	NOUN
fnp-3806	1381	6	.	.	PUNCT
fnp-3806	1382	1	arch	arch	ADJ
fnp-3806	1382	2	pathol	pathol	NOUN
fnp-3806	1382	3	lab	lab	NOUN
fnp-3806	1382	4	med	med	ADJ
fnp-3806	1382	5	1993;117:132	1993;117:132	NUM
fnp-3806	1382	6	-	-	SYM
fnp-3806	1382	7	144	144	NUM
fnp-3806	1382	8	.	.	PUNCT
fnp-3806	1383	1	pmid	pmid	NOUN
fnp-3806	1383	2	:	:	PUNCT
fnp-3806	1383	3	8427562	8427562	NUM
fnp-3806	1383	4	hubbard	hubbard	PROPN
fnp-3806	1383	5	bm	bm	PROPN
fnp-3806	1383	6	,	,	PUNCT
fnp-3806	1383	7	fenton	fenton	PROPN
fnp-3806	1383	8	gw	gw	PROPN
fnp-3806	1383	9	,	,	PUNCT
fnp-3806	1383	10	anderson	anderson	PROPN
fnp-3806	1383	11	jm	jm	PROPN
fnp-3806	1383	12	.	.	PROPN
fnp-3806	1384	1	a	a	DET
fnp-3806	1384	2	quantitative	quantitative	ADJ
fnp-3806	1384	3	histological	histological	ADJ
fnp-3806	1384	4	study	study	NOUN
fnp-3806	1384	5	of	of	ADP
fnp-3806	1384	6	early	early	ADJ
fnp-3806	1384	7	clinical	clinical	ADJ
fnp-3806	1384	8	and	and	CCONJ
fnp-3806	1384	9	preclinical	preclinical	ADJ
fnp-3806	1384	10	alzheimer	alzheimer	PROPN
fnp-3806	1384	11	’s	’s	PART
fnp-3806	1384	12	disease	disease	NOUN
fnp-3806	1384	13	.	.	PUNCT
fnp-3806	1385	1	neuropathol	neuropathol	PROPN
fnp-3806	1385	2	appl	appl	PROPN
fnp-3806	1385	3	neurobiol	neurobiol	PROPN
fnp-3806	1385	4	1990;16:111–121	1990;16:111–121	PROPN
fnp-3806	1385	5	.	.	PUNCT
fnp-3806	1386	1	https://doi.org/10.1111/j.1365-2990.1990.tb00940.x	https://doi.org/10.1111/j.1365-2990.1990.tb00940.x	PROPN
fnp-3806	1386	2	braak	braak	PROPN
fnp-3806	1386	3	h	h	NOUN
fnp-3806	1386	4	,	,	PUNCT
fnp-3806	1386	5	braak	braak	PROPN
fnp-3806	1386	6	e.	e.	PROPN
fnp-3806	1386	7	frequency	frequency	PROPN
fnp-3806	1386	8	of	of	ADP
fnp-3806	1386	9	stages	stage	NOUN
fnp-3806	1386	10	of	of	ADP
fnp-3806	1386	11	alzheimer	alzheimer	NOUN
fnp-3806	1386	12	-	-	PUNCT
fnp-3806	1386	13	related	relate	VERB
fnp-3806	1386	14	lesions	lesion	NOUN
fnp-3806	1386	15	in	in	ADP
fnp-3806	1386	16	different	different	ADJ
fnp-3806	1386	17	age	age	NOUN
fnp-3806	1386	18	categories	category	NOUN
fnp-3806	1386	19	.	.	PUNCT
fnp-3806	1387	1	neurobiol	neurobiol	PROPN
fnp-3806	1387	2	aging	age	VERB
fnp-3806	1387	3	1997	1997	NUM
fnp-3806	1387	4	;	;	PUNCT
fnp-3806	1387	5	18:351	18:351	NUM
fnp-3806	1387	6	-	-	SYM
fnp-3806	1387	7	357	357	NUM
fnp-3806	1387	8	.	.	PUNCT
fnp-3806	1388	1	https://doi.org/10.1016/s0197-4580(97)00056-0	https://doi.org/10.1016/s0197-4580(97)00056-0	PROPN
fnp-3806	1388	2	hulette	hulette	PROPN
fnp-3806	1388	3	c	c	PROPN
fnp-3806	1388	4	,	,	PUNCT
fnp-3806	1388	5	welsh	welsh	NOUN
fnp-3806	1388	6	-	-	PUNCT
fnp-3806	1388	7	bohmer	bohmer	PROPN
fnp-3806	1388	8	k	k	PROPN
fnp-3806	1388	9	,	,	PUNCT
fnp-3806	1388	10	murray	murray	PROPN
fnp-3806	1388	11	m	m	PROPN
fnp-3806	1388	12	,	,	PUNCT
fnp-3806	1388	13	et	et	PROPN
fnp-3806	1388	14	al	al	PROPN
fnp-3806	1388	15	.	.	PROPN
fnp-3806	1389	1	neuropathological	neuropathological	ADJ
fnp-3806	1389	2	and	and	CCONJ
fnp-3806	1389	3	neuropsychological	neuropsychological	ADJ
fnp-3806	1389	4	changes	change	NOUN
fnp-3806	1389	5	in	in	ADP
fnp-3806	1389	6	"	"	PUNCT
fnp-3806	1389	7	normal	normal	ADJ
fnp-3806	1389	8	"	"	PUNCT
fnp-3806	1389	9	aging	aging	NOUN
fnp-3806	1389	10	:	:	PUNCT
fnp-3806	1389	11	evidence	evidence	NOUN
fnp-3806	1389	12	for	for	ADP
fnp-3806	1389	13	preclinical	preclinical	ADJ
fnp-3806	1389	14	alzheimer	alzheimer	NOUN
fnp-3806	1389	15	disease	disease	NOUN
fnp-3806	1389	16	in	in	ADP
fnp-3806	1389	17	cognitively	cognitively	ADV
fnp-3806	1389	18	normal	normal	ADJ
fnp-3806	1389	19	individuals	individual	NOUN
fnp-3806	1389	20	.	.	PUNCT
fnp-3806	1390	1	j	j	PROPN
fnp-3806	1390	2	neuropathol	neuropathol	PROPN
fnp-3806	1390	3	exp	exp	PROPN
fnp-3806	1390	4	neurol	neurol	PROPN
fnp-3806	1390	5	1998;57:1168	1998;57:1168	PROPN
fnp-3806	1390	6	-	-	SYM
fnp-3806	1390	7	1274	1274	NUM
fnp-3806	1390	8	.	.	PUNCT
fnp-3806	1391	1	https://doi.org/10.1097/00005072-199812000-00009	https://doi.org/10.1097/00005072-199812000-00009	PROPN
fnp-3806	1391	2	pmid	pmid	PROPN
fnp-3806	1391	3	:	:	PUNCT
fnp-3806	1391	4	9862640	9862640	NUM
fnp-3806	1391	5	.	.	PUNCT
fnp-3806	1392	1	price	price	PROPN
fnp-3806	1392	2	j	j	PROPN
fnp-3806	1392	3	,	,	PUNCT
fnp-3806	1392	4	morris	morris	PROPN
fnp-3806	1392	5	jc	jc	PROPN
fnp-3806	1392	6	.	.	PROPN
fnp-3806	1393	1	tangles	tangle	NOUN
fnp-3806	1393	2	and	and	CCONJ
fnp-3806	1393	3	plaques	plaque	NOUN
fnp-3806	1393	4	in	in	ADP
fnp-3806	1393	5	non	non	PRON
fnp-3806	1393	6	demented	demented	ADJ
fnp-3806	1393	7	aging	aging	NOUN
fnp-3806	1393	8	and	and	CCONJ
fnp-3806	1393	9	"	"	PUNCT
fnp-3806	1393	10	preclinical	preclinical	ADJ
fnp-3806	1393	11	"	"	PUNCT
fnp-3806	1393	12	alzheimer	alzheimer	PROPN
fnp-3806	1393	13	's	's	PART
fnp-3806	1393	14	disease	disease	NOUN
fnp-3806	1393	15	.	.	PUNCT
fnp-3806	1394	1	ann	ann	PROPN
fnp-3806	1394	2	neurol	neurol	PROPN
fnp-3806	1394	3	1999;45:358	1999;45:358	PROPN
fnp-3806	1394	4	-	-	SYM
fnp-3806	1394	5	368	368	NUM
fnp-3806	1394	6	.	.	PUNCT
fnp-3806	1395	1	https://doi.org/10.1002/1531-8249(199903)45:3<358::aid-ana12>3.0.co;2-x	https://doi.org/10.1002/1531-8249(199903)45:3<358::aid-ana12>3.0.co;2-x	PROPN
fnp-3806	1395	2	khachaturian	khachaturian	PROPN
fnp-3806	1395	3	zs	zs	PROPN
fnp-3806	1395	4	.	.	PUNCT
fnp-3806	1395	5	diagnosis	diagnosis	NOUN
fnp-3806	1395	6	of	of	ADP
fnp-3806	1395	7	alzheimer	alzheimer	PROPN
fnp-3806	1395	8	's	's	PART
fnp-3806	1395	9	disease	disease	NOUN
fnp-3806	1395	10	:	:	PUNCT
fnp-3806	1395	11	two	two	NUM
fnp-3806	1395	12	-	-	PUNCT
fnp-3806	1395	13	decades	decade	NOUN
fnp-3806	1395	14	of	of	ADP
fnp-3806	1395	15	progress	progress	NOUN
fnp-3806	1395	16	.	.	PUNCT
fnp-3806	1396	1	j	j	PROPN
fnp-3806	1396	2	alzheimers	alzheimers	PROPN
fnp-3806	1396	3	dis	dis	PROPN
fnp-3806	1396	4	2006;9:409	2006;9:409	PROPN
fnp-3806	1396	5	-	-	NUM
fnp-3806	1396	6	415	415	NUM
fnp-3806	1396	7	.	.	PUNCT
fnp-3806	1397	1	https://doi.org/10.3233/jad-2006-9s346	https://doi.org/10.3233/jad-2006-9s346	ADJ
fnp-3806	1397	2	dubois	dubois	PROPN
fnp-3806	1397	3	b	b	PROPN
fnp-3806	1397	4	,	,	PUNCT
fnp-3806	1397	5	feldman	feldman	PROPN
fnp-3806	1397	6	hh	hh	PROPN
fnp-3806	1397	7	,	,	PUNCT
fnp-3806	1397	8	jacova	jacova	VERB
fnp-3806	1397	9	c	c	X
fnp-3806	1397	10	,	,	PUNCT
fnp-3806	1397	11	et	et	PROPN
fnp-3806	1397	12	al	al	PROPN
fnp-3806	1397	13	.	.	PROPN
fnp-3806	1398	1	revising	revise	VERB
fnp-3806	1398	2	the	the	DET
fnp-3806	1398	3	definition	definition	NOUN
fnp-3806	1398	4	of	of	ADP
fnp-3806	1398	5	alzheimer	alzheimer	PROPN
fnp-3806	1398	6	's	's	PART
fnp-3806	1398	7	disease	disease	NOUN
fnp-3806	1398	8	:	:	PUNCT
fnp-3806	1398	9	a	a	DET
fnp-3806	1398	10	new	new	ADJ
fnp-3806	1398	11	lexicon	lexicon	NOUN
fnp-3806	1398	12	.	.	PUNCT
fnp-3806	1399	1	lancet	lancet	PROPN
fnp-3806	1399	2	neurol	neurol	PROPN
fnp-3806	1399	3	2010;9:1118	2010;9:1118	NUM
fnp-3806	1399	4	-	-	SYM
fnp-3806	1399	5	1127	1127	NUM
fnp-3806	1399	6	.	.	PUNCT
fnp-3806	1400	1	https://doi.org/10.1016/s1474-4422(10)70223-4	https://doi.org/10.1016/s1474-4422(10)70223-4	PROPN
fnp-3806	1400	2	albert	albert	PROPN
fnp-3806	1400	3	ms	ms	PROPN
fnp-3806	1400	4	,	,	PUNCT
fnp-3806	1400	5	dekosky	dekosky	PROPN
fnp-3806	1400	6	st	st	PROPN
fnp-3806	1400	7	,	,	PUNCT
fnp-3806	1400	8	dickson	dickson	PROPN
fnp-3806	1400	9	d	d	PROPN
fnp-3806	1400	10	,	,	PUNCT
fnp-3806	1400	11	et	et	PROPN
fnp-3806	1400	12	al	al	PROPN
fnp-3806	1400	13	.	.	PUNCT
fnp-3806	1401	1	the	the	DET
fnp-3806	1401	2	diagnosis	diagnosis	NOUN
fnp-3806	1401	3	of	of	ADP
fnp-3806	1401	4	mild	mild	ADJ
fnp-3806	1401	5	cognitive	cognitive	ADJ
fnp-3806	1401	6	impairment	impairment	NOUN
fnp-3806	1401	7	due	due	ADP
fnp-3806	1401	8	to	to	ADP
fnp-3806	1401	9	alzheimer	alzheimer	PROPN
fnp-3806	1401	10	’s	’s	PART
fnp-3806	1401	11	disease	disease	NOUN
fnp-3806	1401	12	:	:	PUNCT
fnp-3806	1401	13	recommendations	recommendation	NOUN
fnp-3806	1401	14	from	from	ADP
fnp-3806	1401	15	the	the	DET
fnp-3806	1401	16	national	national	PROPN
fnp-3806	1401	17	institute	institute	PROPN
fnp-3806	1401	18	on	on	ADP
fnp-3806	1401	19	aging	age	VERB
fnp-3806	1401	20	-	-	PUNCT
fnp-3806	1401	21	alzheimer	alzheimer	NOUN
fnp-3806	1401	22	’s	’s	PART
fnp-3806	1401	23	association	association	NOUN
fnp-3806	1401	24	workgroups	workgroup	NOUN
fnp-3806	1401	25	on	on	ADP
fnp-3806	1401	26	diagnostic	diagnostic	ADJ
fnp-3806	1401	27	guidelines	guideline	NOUN
fnp-3806	1401	28	for	for	ADP
fnp-3806	1401	29	alzheimer	alzheimer	PROPN
fnp-3806	1401	30	’s	’s	PART
fnp-3806	1401	31	disease	disease	NOUN
fnp-3806	1401	32	.	.	PUNCT
fnp-3806	1402	1	alzheimers	alzheimers	PROPN
fnp-3806	1402	2	dement	dement	PROPN
fnp-3806	1402	3	2011	2011	NUM
fnp-3806	1402	4	;	;	PUNCT
fnp-3806	1403	1	7:270–279	7:270–279	NUM
fnp-3806	1403	2	.	.	PUNCT
fnp-3806	1404	1	https://doi.org/10.1016/j.jalz.2011.03.008	https://doi.org/10.1016/j.jalz.2011.03.008	PROPN
fnp-3806	1404	2	mckhann	mckhann	PROPN
fnp-3806	1404	3	gm	gm	PROPN
fnp-3806	1404	4	,	,	PUNCT
fnp-3806	1404	5	knopman	knopman	NOUN
fnp-3806	1404	6	ds	ds	PROPN
fnp-3806	1404	7	,	,	PUNCT
fnp-3806	1404	8	chertkow	chertkow	VERB
fnp-3806	1404	9	h	h	NOUN
fnp-3806	1404	10	,	,	PUNCT
fnp-3806	1404	11	et	et	PROPN
fnp-3806	1404	12	al	al	PROPN
fnp-3806	1404	13	.	.	PUNCT
fnp-3806	1405	1	the	the	DET
fnp-3806	1405	2	diagnosis	diagnosis	NOUN
fnp-3806	1405	3	of	of	ADP
fnp-3806	1405	4	dementia	dementia	NOUN
fnp-3806	1405	5	due	due	ADP
fnp-3806	1405	6	to	to	ADP
fnp-3806	1405	7	alzheimer	alzheimer	PROPN
fnp-3806	1405	8	's	's	PART
fnp-3806	1405	9	disease	disease	NOUN
fnp-3806	1405	10	:	:	PUNCT
fnp-3806	1405	11	recommendations	recommendation	NOUN
fnp-3806	1405	12	from	from	ADP
fnp-3806	1405	13	the	the	DET
fnp-3806	1405	14	national	national	PROPN
fnp-3806	1405	15	institute	institute	PROPN
fnp-3806	1405	16	on	on	ADP
fnp-3806	1405	17	aging	age	VERB
fnp-3806	1405	18	-	-	PUNCT
fnp-3806	1405	19	alzheimer	alzheimer	NOUN
fnp-3806	1405	20	's	's	PART
fnp-3806	1405	21	association	association	NOUN
fnp-3806	1405	22	workgroups	workgroup	NOUN
fnp-3806	1405	23	on	on	ADP
fnp-3806	1405	24	diagnostic	diagnostic	ADJ
fnp-3806	1405	25	guidelines	guideline	NOUN
fnp-3806	1405	26	for	for	ADP
fnp-3806	1405	27	alzheimer	alzheimer	PROPN
fnp-3806	1405	28	's	's	PART
fnp-3806	1405	29	disease	disease	NOUN
fnp-3806	1405	30	.	.	PUNCT
fnp-3806	1406	1	alzheimers	alzheimers	PROPN
fnp-3806	1406	2	dement	dement	PROPN
fnp-3806	1406	3	2011;7:263	2011;7:263	PROPN
fnp-3806	1406	4	-	-	SYM
fnp-3806	1406	5	269	269	NUM
fnp-3806	1406	6	.	.	PUNCT
fnp-3806	1407	1	https://doi.org/10.1016/j.jalz.2011.03.005	https://doi.org/10.1016/j.jalz.2011.03.005	PROPN
fnp-3806	1407	2	sperling	sperling	PROPN
fnp-3806	1407	3	ra	ra	PROPN
fnp-3806	1407	4	,	,	PUNCT
fnp-3806	1407	5	aisen	aisen	PROPN
fnp-3806	1407	6	ps	ps	PROPN
fnp-3806	1407	7	,	,	PUNCT
fnp-3806	1407	8	beckett	beckett	PROPN
fnp-3806	1407	9	la	la	PROPN
fnp-3806	1407	10	,	,	PUNCT
fnp-3806	1407	11	et	et	PROPN
fnp-3806	1407	12	al	al	PROPN
fnp-3806	1407	13	.	.	PROPN
fnp-3806	1408	1	toward	toward	ADP
fnp-3806	1408	2	defining	define	VERB
fnp-3806	1408	3	the	the	DET
fnp-3806	1408	4	preclinical	preclinical	ADJ
fnp-3806	1408	5	stages	stage	NOUN
fnp-3806	1408	6	of	of	ADP
fnp-3806	1408	7	alzheimer	alzheimer	PROPN
fnp-3806	1408	8	's	's	PART
fnp-3806	1408	9	disease	disease	NOUN
fnp-3806	1408	10	:	:	PUNCT
fnp-3806	1408	11	recommendations	recommendation	NOUN
fnp-3806	1408	12	from	from	ADP
fnp-3806	1408	13	the	the	DET
fnp-3806	1408	14	national	national	PROPN
fnp-3806	1408	15	institute	institute	PROPN
fnp-3806	1408	16	on	on	ADP
fnp-3806	1408	17	aging	age	VERB
fnp-3806	1408	18	-	-	PUNCT
fnp-3806	1408	19	alzheimer	alzheimer	NOUN
fnp-3806	1408	20	's	's	PART
fnp-3806	1408	21	association	association	NOUN
fnp-3806	1408	22	workgroups	workgroup	NOUN
fnp-3806	1408	23	on	on	ADP
fnp-3806	1408	24	diagnostic	diagnostic	ADJ
fnp-3806	1408	25	guidelines	guideline	NOUN
fnp-3806	1408	26	for	for	ADP
fnp-3806	1408	27	alzheimer	alzheimer	PROPN
fnp-3806	1408	28	's	's	PART
fnp-3806	1408	29	disease	disease	NOUN
fnp-3806	1408	30	.	.	PUNCT
fnp-3806	1409	1	alzheimers	alzheimers	PROPN
fnp-3806	1409	2	dement	dement	PROPN
fnp-3806	1409	3	2011;7:280	2011;7:280	PROPN
fnp-3806	1409	4	-	-	PUNCT
fnp-3806	1409	5	292	292	NUM
fnp-3806	1409	6	.	.	PUNCT
fnp-3806	1410	1	https://doi.org/10.1016/j.jalz.2011.03.003	https://doi.org/10.1016/j.jalz.2011.03.003	NUM
fnp-3806	1410	2	hyman	hyman	PROPN
fnp-3806	1410	3	bt	bt	PROPN
fnp-3806	1410	4	,	,	PUNCT
fnp-3806	1410	5	phelps	phelps	PROPN
fnp-3806	1410	6	ch	ch	PROPN
fnp-3806	1410	7	,	,	PUNCT
fnp-3806	1410	8	beach	beach	PROPN
fnp-3806	1410	9	tg	tg	PROPN
fnp-3806	1410	10	,	,	PUNCT
fnp-3806	1410	11	et	et	PROPN
fnp-3806	1410	12	al	al	PROPN
fnp-3806	1410	13	.	.	PROPN
fnp-3806	1410	14	national	national	PROPN
fnp-3806	1410	15	institute	institute	PROPN
fnp-3806	1410	16	on	on	ADP
fnp-3806	1410	17	aging	age	VERB
fnp-3806	1410	18	-	-	PUNCT
fnp-3806	1410	19	alzheimer	alzheimer	NOUN
fnp-3806	1410	20	's	's	PART
fnp-3806	1410	21	association	association	NOUN
fnp-3806	1410	22	guidelines	guideline	NOUN
fnp-3806	1410	23	for	for	ADP
fnp-3806	1410	24	the	the	DET
fnp-3806	1410	25	neuropathologic	neuropathologic	ADJ
fnp-3806	1410	26	assessment	assessment	NOUN
fnp-3806	1410	27	of	of	ADP
fnp-3806	1410	28	alzheimer	alzheimer	PROPN
fnp-3806	1410	29	's	's	PART
fnp-3806	1410	30	disease	disease	NOUN
fnp-3806	1410	31	.	.	PUNCT
fnp-3806	1411	1	alzheimers	alzheimers	PROPN
fnp-3806	1411	2	dement	dement	PROPN
fnp-3806	1411	3	2012;8:1	2012;8:1	PROPN
fnp-3806	1411	4	-	-	SYM
fnp-3806	1411	5	13	13	NUM
fnp-3806	1411	6	.	.	PUNCT
fnp-3806	1412	1	https://doi.org/10.1016/j.jalz.2011.10.007	https://doi.org/10.1016/j.jalz.2011.10.007	ADJ
fnp-3806	1412	2	montine	montine	PROPN
fnp-3806	1412	3	tj	tj	PROPN
fnp-3806	1412	4	,	,	PUNCT
fnp-3806	1412	5	phelps	phelps	PROPN
fnp-3806	1412	6	ch	ch	PROPN
fnp-3806	1412	7	,	,	PUNCT
fnp-3806	1412	8	beach	beach	PROPN
fnp-3806	1412	9	tg	tg	PROPN
fnp-3806	1412	10	,	,	PUNCT
fnp-3806	1412	11	et	et	PROPN
fnp-3806	1412	12	al	al	PROPN
fnp-3806	1412	13	.	.	PROPN
fnp-3806	1412	14	national	national	PROPN
fnp-3806	1412	15	institute	institute	PROPN
fnp-3806	1412	16	on	on	ADP
fnp-3806	1412	17	aging	age	VERB
fnp-3806	1412	18	-	-	PUNCT
fnp-3806	1412	19	alzheimer	alzheimer	NOUN
fnp-3806	1412	20	's	's	PART
fnp-3806	1412	21	association	association	NOUN
fnp-3806	1412	22	guidelines	guideline	NOUN
fnp-3806	1412	23	for	for	ADP
fnp-3806	1412	24	the	the	DET
fnp-3806	1412	25	neuropathologic	neuropathologic	ADJ
fnp-3806	1412	26	assessment	assessment	NOUN
fnp-3806	1412	27	of	of	ADP
fnp-3806	1412	28	alzheimer	alzheimer	PROPN
fnp-3806	1412	29	's	's	PART
fnp-3806	1412	30	disease	disease	NOUN
fnp-3806	1412	31	:	:	PUNCT
fnp-3806	1412	32	a	a	DET
fnp-3806	1412	33	practical	practical	ADJ
fnp-3806	1412	34	approach	approach	NOUN
fnp-3806	1412	35	.	.	PUNCT
fnp-3806	1413	1	acta	acta	PROPN
fnp-3806	1413	2	neuropathol	neuropathol	PROPN
fnp-3806	1413	3	2012;123:1	2012;123:1	NUM
fnp-3806	1413	4	-	-	SYM
fnp-3806	1413	5	11	11	NUM
fnp-3806	1413	6	.	.	PUNCT
fnp-3806	1414	1	https://doi.org/10.1007/s00401-011-0910-3	https://doi.org/10.1007/s00401-011-0910-3	NUM
fnp-3806	1414	2	jack	jack	PROPN
fnp-3806	1414	3	cr	cr	PROPN
fnp-3806	1414	4	,	,	PUNCT
fnp-3806	1414	5	bennett	bennett	PROPN
fnp-3806	1414	6	da	da	PROPN
fnp-3806	1414	7	,	,	PUNCT
fnp-3806	1414	8	blennow	blennow	ADV
fnp-3806	1414	9	k	k	PROPN
fnp-3806	1414	10	,	,	PUNCT
fnp-3806	1414	11	et	et	PROPN
fnp-3806	1414	12	al	al	PROPN
fnp-3806	1414	13	.	.	PUNCT
fnp-3806	1415	1	nia	nia	PROPN
fnp-3806	1415	2	-	-	PUNCT
fnp-3806	1415	3	aa	aa	PROPN
fnp-3806	1415	4	research	research	NOUN
fnp-3806	1415	5	framework	framework	NOUN
fnp-3806	1415	6	:	:	PUNCT
fnp-3806	1415	7	toward	toward	ADP
fnp-3806	1415	8	a	a	DET
fnp-3806	1415	9	biological	biological	ADJ
fnp-3806	1415	10	definition	definition	NOUN
fnp-3806	1415	11	of	of	ADP
fnp-3806	1415	12	alzheimer	alzheimer	PROPN
fnp-3806	1415	13	’s	’s	PART
fnp-3806	1415	14	disease	disease	NOUN
fnp-3806	1415	15	.	.	PUNCT
fnp-3806	1416	1	alzheimers	alzheimers	PROPN
fnp-3806	1416	2	dement	dement	PROPN
fnp-3806	1416	3	2018;14:535	2018;14:535	PROPN
fnp-3806	1416	4	-	-	SYM
fnp-3806	1416	5	562	562	NUM
fnp-3806	1416	6	.	.	PUNCT
fnp-3806	1417	1	https://doi.org/10.1016/j.jalz.2018.02.018	https://doi.org/10.1016/j.jalz.2018.02.018	NOUN
fnp-3806	1417	2	ward	ward	VERB
fnp-3806	1417	3	a	a	DET
fnp-3806	1417	4	,	,	PUNCT
fnp-3806	1417	5	tardiff	tardiff	PROPN
fnp-3806	1417	6	s	s	PART
fnp-3806	1417	7	,	,	PUNCT
fnp-3806	1417	8	dye	dye	NOUN
fnp-3806	1417	9	c	c	X
fnp-3806	1417	10	,	,	PUNCT
fnp-3806	1417	11	et	et	PROPN
fnp-3806	1417	12	al	al	PROPN
fnp-3806	1417	13	.	.	PUNCT
fnp-3806	1417	14	rate	rate	NOUN
fnp-3806	1417	15	of	of	ADP
fnp-3806	1417	16	conversion	conversion	NOUN
fnp-3806	1417	17	from	from	ADP
fnp-3806	1417	18	prodromal	prodromal	ADJ
fnp-3806	1417	19	alzheimer	alzheimer	PROPN
fnp-3806	1417	20	’s	’s	PART
fnp-3806	1417	21	disease	disease	NOUN
fnp-3806	1417	22	to	to	ADP
fnp-3806	1417	23	alzheimer	alzheimer	PROPN
fnp-3806	1417	24	’s	’s	PART
fnp-3806	1417	25	dementia	dementia	PROPN
fnp-3806	1417	26	:	:	PUNCT
fnp-3806	1417	27	a	a	DET
fnp-3806	1417	28	systematic	systematic	ADJ
fnp-3806	1417	29	review	review	NOUN
fnp-3806	1417	30	of	of	ADP
fnp-3806	1417	31	the	the	DET
fnp-3806	1417	32	literature	literature	NOUN
fnp-3806	1417	33	.	.	PUNCT
fnp-3806	1418	1	dement	dement	PROPN
fnp-3806	1418	2	geriatr	geriatr	PROPN
fnp-3806	1418	3	cogn	cogn	PROPN
fnp-3806	1418	4	disord	disord	NOUN
fnp-3806	1418	5	extra	extra	ADJ
fnp-3806	1418	6	2013;3:320	2013;3:320	NOUN
fnp-3806	1418	7	-	-	SYM
fnp-3806	1418	8	332	332	NUM
fnp-3806	1418	9	.	.	PUNCT
fnp-3806	1419	1	https://doi.org/10.1159/000354370	https://doi.org/10.1159/000354370	PROPN
fnp-3806	1419	2	petersen	petersen	PROPN
fnp-3806	1419	3	rc	rc	PROPN
fnp-3806	1419	4	,	,	PUNCT
fnp-3806	1419	5	lopez	lopez	PROPN
fnp-3806	1419	6	o	o	PROPN
fnp-3806	1419	7	,	,	PUNCT
fnp-3806	1419	8	armstrong	armstrong	PROPN
fnp-3806	1419	9	mj	mj	PROPN
fnp-3806	1419	10	,	,	PUNCT
fnp-3806	1419	11	et	et	PROPN
fnp-3806	1419	12	al	al	PROPN
fnp-3806	1419	13	.	.	PUNCT
fnp-3806	1419	14	practice	practice	PROPN
fnp-3806	1419	15	guideline	guideline	NOUN
fnp-3806	1419	16	update	update	NOUN
fnp-3806	1419	17	summary	summary	NOUN
fnp-3806	1419	18	:	:	PUNCT
fnp-3806	1419	19	mild	mild	ADJ
fnp-3806	1419	20	cognitive	cognitive	ADJ
fnp-3806	1419	21	impairment	impairment	NOUN
fnp-3806	1419	22	.	.	PUNCT
fnp-3806	1420	1	neurology	neurology	NOUN
fnp-3806	1420	2	2018;90:126	2018;90:126	NOUN
fnp-3806	1420	3	-	-	SYM
fnp-3806	1420	4	135	135	NUM
fnp-3806	1420	5	.	.	PUNCT
fnp-3806	1421	1	https://doi.org/10.1212/wnl.0000000000004826	https://doi.org/10.1212/wnl.0000000000004826	PROPN
fnp-3806	1421	2	gao	gao	PROPN
fnp-3806	1421	3	s	s	PROPN
fnp-3806	1421	4	,	,	PUNCT
fnp-3806	1421	5	hendrie	hendrie	PROPN
fnp-3806	1421	6	hc	hc	PROPN
fnp-3806	1421	7	,	,	PUNCT
fnp-3806	1421	8	hall	hall	PROPN
fnp-3806	1421	9	ks	ks	PROPN
fnp-3806	1421	10	,	,	PUNCT
fnp-3806	1421	11	et	et	PROPN
fnp-3806	1421	12	al	al	PROPN
fnp-3806	1421	13	.	.	PUNCT
fnp-3806	1422	1	the	the	DET
fnp-3806	1422	2	relationships	relationship	NOUN
fnp-3806	1422	3	between	between	ADP
fnp-3806	1422	4	age	age	NOUN
fnp-3806	1422	5	,	,	PUNCT
fnp-3806	1422	6	sex	sex	NOUN
fnp-3806	1422	7	,	,	PUNCT
fnp-3806	1422	8	and	and	CCONJ
fnp-3806	1422	9	the	the	DET
fnp-3806	1422	10	incidence	incidence	NOUN
fnp-3806	1422	11	of	of	ADP
fnp-3806	1422	12	dementia	dementia	NOUN
fnp-3806	1422	13	and	and	CCONJ
fnp-3806	1422	14	alzheimer	alzheimer	PROPN
fnp-3806	1422	15	disease	disease	PROPN
fnp-3806	1422	16	:	:	PUNCT
fnp-3806	1422	17	a	a	DET
fnp-3806	1422	18	meta	meta	ADJ
fnp-3806	1422	19	-	-	PUNCT
fnp-3806	1422	20	analysis	analysis	NOUN
fnp-3806	1422	21	.	.	PUNCT
fnp-3806	1423	1	arch	arch	ADJ
fnp-3806	1423	2	gen	gen	PROPN
fnp-3806	1423	3	psych	psych	NOUN
fnp-3806	1423	4	1998	1998	NUM
fnp-3806	1423	5	;	;	PUNCT
fnp-3806	1423	6	55:809	55:809	NUM
fnp-3806	1423	7	-	-	SYM
fnp-3806	1423	8	815	815	NUM
fnp-3806	1423	9	.	.	PUNCT
fnp-3806	1424	1	https://doi.org/10.1001/archpsyc.55.9.809	https://doi.org/10.1001/archpsyc.55.9.809	PROPN
fnp-3806	1424	2	vermunt	vermunt	PROPN
fnp-3806	1424	3	l	l	PROPN
fnp-3806	1424	4	,	,	PUNCT
fnp-3806	1424	5	sikkes	sikke	VERB
fnp-3806	1424	6	sam	sam	PROPN
fnp-3806	1424	7	,	,	PUNCT
fnp-3806	1424	8	van	van	PROPN
fnp-3806	1424	9	den	den	PROPN
fnp-3806	1424	10	hout	hout	PROPN
fnp-3806	1424	11	a	a	PRON
fnp-3806	1424	12	,	,	PUNCT
fnp-3806	1424	13	et	et	PROPN
fnp-3806	1424	14	al	al	PROPN
fnp-3806	1424	15	.	.	PUNCT
fnp-3806	1424	16	duration	duration	NOUN
fnp-3806	1424	17	of	of	ADP
fnp-3806	1424	18	preclinical	preclinical	ADJ
fnp-3806	1424	19	,	,	PUNCT
fnp-3806	1424	20	prodromal	prodromal	ADJ
fnp-3806	1424	21	,	,	PUNCT
fnp-3806	1424	22	and	and	CCONJ
fnp-3806	1424	23	dementia	dementia	NOUN
fnp-3806	1424	24	stages	stage	NOUN
fnp-3806	1424	25	of	of	ADP
fnp-3806	1424	26	alzheimer	alzheimer	PROPN
fnp-3806	1424	27	’s	’s	PART
fnp-3806	1424	28	disease	disease	NOUN
fnp-3806	1424	29	in	in	ADP
fnp-3806	1424	30	relation	relation	NOUN
fnp-3806	1424	31	to	to	ADP
fnp-3806	1424	32	age	age	NOUN
fnp-3806	1424	33	,	,	PUNCT
fnp-3806	1424	34	sex	sex	NOUN
fnp-3806	1424	35	,	,	PUNCT
fnp-3806	1424	36	and	and	CCONJ
fnp-3806	1424	37	apoe	apoe	ADJ
fnp-3806	1424	38	genotype	genotype	NOUN
fnp-3806	1424	39	.	.	PUNCT
fnp-3806	1425	1	alzheimers	alzheimers	PROPN
fnp-3806	1425	2	dement	dement	PROPN
fnp-3806	1425	3	2019;15:888	2019;15:888	PROPN
fnp-3806	1425	4	-	-	SYM
fnp-3806	1425	5	898	898	NUM
fnp-3806	1425	6	.	.	PUNCT
fnp-3806	1426	1	https://doi.org/10.1016/j.jalz.2019.04.001	https://doi.org/10.1016/j.jalz.2019.04.001	ADJ
fnp-3806	1426	2	kidd	kidd	PROPN
fnp-3806	1426	3	m.	m.	NOUN
fnp-3806	1426	4	paired	pair	VERB
fnp-3806	1426	5	helical	helical	ADJ
fnp-3806	1426	6	filaments	filament	NOUN
fnp-3806	1426	7	in	in	ADP
fnp-3806	1426	8	electron	electron	NOUN
fnp-3806	1426	9	microscopy	microscopy	NOUN
fnp-3806	1426	10	of	of	ADP
fnp-3806	1426	11	alzheimer	alzheimer	PROPN
fnp-3806	1426	12	's	's	PART
fnp-3806	1426	13	disease	disease	NOUN
fnp-3806	1426	14	.	.	PUNCT
fnp-3806	1427	1	nature	nature	NOUN
fnp-3806	1427	2	1963	1963	NUM
fnp-3806	1427	3	;	;	PUNCT
fnp-3806	1427	4	197	197	NUM
fnp-3806	1427	5	:	:	SYM
fnp-3806	1427	6	192	192	NUM
fnp-3806	1427	7	-	-	SYM
fnp-3806	1427	8	193	193	NUM
fnp-3806	1427	9	.	.	PUNCT
fnp-3806	1428	1	pmid	pmid	NOUN
fnp-3806	1428	2	:	:	PUNCT
fnp-3806	1428	3	14032480	14032480	NUM
fnp-3806	1428	4	.	.	PUNCT
fnp-3806	1429	1	kidd	kidd	PROPN
fnp-3806	1429	2	m.	m.	PROPN
fnp-3806	1429	3	alzheimer	alzheimer	PROPN
fnp-3806	1429	4	’s	’s	PART
fnp-3806	1429	5	diseasean	diseasean	ADJ
fnp-3806	1429	6	alectron	alectron	PROPN
fnp-3806	1429	7	microscopical	microscopical	ADJ
fnp-3806	1429	8	study	study	NOUN
fnp-3806	1429	9	.	.	PUNCT
fnp-3806	1430	1	brain	brain	NOUN
fnp-3806	1430	2	1964;87:307	1964;87:307	NUM
fnp-3806	1430	3	-	-	SYM
fnp-3806	1430	4	320	320	NUM
fnp-3806	1430	5	.	.	PUNCT
fnp-3806	1431	1	https://doi.org/10.1093/brain/87.2.307	https://doi.org/10.1093/brain/87.2.307	PROPN
fnp-3806	1431	2	terry	terry	PROPN
fnp-3806	1431	3	rd	rd	PROPN
fnp-3806	1431	4	.	.	PUNCT
fnp-3806	1432	1	the	the	DET
fnp-3806	1432	2	fine	fine	ADJ
fnp-3806	1432	3	structure	structure	NOUN
fnp-3806	1432	4	of	of	ADP
fnp-3806	1432	5	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1432	6	tangles	tangle	NOUN
fnp-3806	1432	7	in	in	ADP
fnp-3806	1432	8	alzheimer	alzheimer	PROPN
fnp-3806	1432	9	’s	’s	PART
fnp-3806	1432	10	disease	disease	NOUN
fnp-3806	1432	11	.	.	PUNCT
fnp-3806	1433	1	j	j	PROPN
fnp-3806	1433	2	neuropathol	neuropathol	PROPN
fnp-3806	1433	3	exp	exp	PROPN
fnp-3806	1433	4	neurol	neurol	PROPN
fnp-3806	1433	5	1963;22:629	1963;22:629	NOUN
fnp-3806	1433	6	-	-	SYM
fnp-3806	1433	7	642	642	NUM
fnp-3806	1433	8	.	.	PUNCT
fnp-3806	1434	1	https://doi.org/10.1097/00005072-196310000-00005	https://doi.org/10.1097/00005072-196310000-00005	PROPN
fnp-3806	1434	2	terry	terry	PROPN
fnp-3806	1434	3	rd	rd	PROPN
fnp-3806	1434	4	,	,	PUNCT
fnp-3806	1434	5	gonatas	gonatas	PROPN
fnp-3806	1434	6	nk	nk	PROPN
fnp-3806	1434	7	,	,	PUNCT
fnp-3806	1434	8	weiss	weiss	PROPN
fnp-3806	1434	9	m.	m.	NOUN
fnp-3806	1434	10	ultrastructural	ultrastructural	ADJ
fnp-3806	1434	11	studies	study	NOUN
fnp-3806	1434	12	in	in	ADP
fnp-3806	1434	13	alzheimer	alzheimer	PROPN
fnp-3806	1434	14	’s	’s	PART
fnp-3806	1434	15	presenile	presenile	PROPN
fnp-3806	1434	16	dementia	dementia	PROPN
fnp-3806	1434	17	.	.	PUNCT
fnp-3806	1434	18	am	be	AUX
fnp-3806	1434	19	j	j	PROPN
fnp-3806	1434	20	pathol	pathol	NOUN
fnp-3806	1434	21	1964;44	1964;44	NUM
fnp-3806	1434	22	:	:	PUNCT
fnp-3806	1434	23	269	269	NUM
fnp-3806	1434	24	-	-	SYM
fnp-3806	1434	25	297	297	NUM
fnp-3806	1434	26	.	.	PUNCT
fnp-3806	1435	1	pmid	pmid	NOUN
fnp-3806	1435	2	:	:	PUNCT
fnp-3806	1435	3	14119171	14119171	NUM
fnp-3806	1435	4	.	.	PUNCT
fnp-3806	1436	1	luse	luse	PROPN
fnp-3806	1436	2	sa	sa	PROPN
fnp-3806	1436	3	,	,	PUNCT
fnp-3806	1436	4	smith	smith	PROPN
fnp-3806	1436	5	kr	kr	PROPN
fnp-3806	1436	6	.	.	PUNCT
fnp-3806	1437	1	the	the	DET
fnp-3806	1437	2	ultrastructure	ultrastructure	NOUN
fnp-3806	1437	3	of	of	ADP
fnp-3806	1437	4	senile	senile	ADJ
fnp-3806	1437	5	plaques	plaque	NOUN
fnp-3806	1437	6	.	.	PUNCT
fnp-3806	1438	1	am	be	AUX
fnp-3806	1438	2	j	j	PROPN
fnp-3806	1438	3	pathol	pathol	NOUN
fnp-3806	1438	4	1964;44:553	1964;44:553	PROPN
fnp-3806	1438	5	-	-	SYM
fnp-3806	1438	6	563	563	NUM
fnp-3806	1438	7	.	.	PUNCT
fnp-3806	1439	1	pmid	pmid	NOUN
fnp-3806	1439	2	:	:	PUNCT
fnp-3806	1439	3	5877505	5877505	NUM
fnp-3806	1439	4	.	.	PUNCT
fnp-3806	1440	1	wisniewski	wisniewski	PROPN
fnp-3806	1440	2	h	h	PROPN
fnp-3806	1440	3	,	,	PUNCT
fnp-3806	1440	4	terry	terry	PROPN
fnp-3806	1440	5	rd	rd	PROPN
fnp-3806	1440	6	,	,	PUNCT
fnp-3806	1440	7	hirano	hirano	PROPN
fnp-3806	1440	8	a.	a.	PROPN
fnp-3806	1440	9	neurofibrillary	neurofibrillary	PROPN
fnp-3806	1440	10	pathology	pathology	PROPN
fnp-3806	1440	11	.	.	PUNCT
fnp-3806	1441	1	j	j	PROPN
fnp-3806	1441	2	neuropathol	neuropathol	PROPN
fnp-3806	1441	3	exp	exp	PROPN
fnp-3806	1441	4	neurol	neurol	PROPN
fnp-3806	1441	5	1970	1970	NUM
fnp-3806	1441	6	;	;	PUNCT
fnp-3806	1441	7	29	29	NUM
fnp-3806	1441	8	:	:	SYM
fnp-3806	1441	9	163	163	NUM
fnp-3806	1441	10	-	-	SYM
fnp-3806	1441	11	176	176	NUM
fnp-3806	1441	12	.	.	PUNCT
fnp-3806	1442	1	pmid	pmid	NOUN
fnp-3806	1442	2	:	:	PUNCT
fnp-3806	1442	3	5435819	5435819	NUM
fnp-3806	1442	4	.	.	PUNCT
fnp-3806	1443	1	glenner	glenner	PROPN
fnp-3806	1443	2	gg	gg	PROPN
fnp-3806	1443	3	,	,	PUNCT
fnp-3806	1443	4	wong	wong	PROPN
fnp-3806	1443	5	cw	cw	PROPN
fnp-3806	1443	6	.	.	PROPN
fnp-3806	1443	7	alzheimer	alzheimer	PROPN
fnp-3806	1443	8	's	's	PART
fnp-3806	1443	9	disease	disease	NOUN
fnp-3806	1443	10	:	:	PUNCT
fnp-3806	1443	11	initial	initial	ADJ
fnp-3806	1443	12	report	report	NOUN
fnp-3806	1443	13	of	of	ADP
fnp-3806	1443	14	the	the	DET
fnp-3806	1443	15	purification	purification	NOUN
fnp-3806	1443	16	and	and	CCONJ
fnp-3806	1443	17	characterization	characterization	NOUN
fnp-3806	1443	18	of	of	ADP
fnp-3806	1443	19	a	a	DET
fnp-3806	1443	20	novel	novel	ADJ
fnp-3806	1443	21	cerebrovascular	cerebrovascular	ADJ
fnp-3806	1443	22	amyloid	amyloid	NOUN
fnp-3806	1443	23	protein	protein	NOUN
fnp-3806	1443	24	.	.	PUNCT
fnp-3806	1444	1	biochem	biochem	PROPN
fnp-3806	1444	2	biophys	biophys	PROPN
fnp-3806	1444	3	res	res	PROPN
fnp-3806	1444	4	commun	commun	PROPN
fnp-3806	1444	5	1984	1984	NUM
fnp-3806	1444	6	;	;	PUNCT
fnp-3806	1444	7	120	120	NUM
fnp-3806	1444	8	:	:	SYM
fnp-3806	1444	9	885	885	NUM
fnp-3806	1444	10	-	-	SYM
fnp-3806	1444	11	890	890	NUM
fnp-3806	1444	12	.	.	PUNCT
fnp-3806	1444	13	https://doi.org/10.1016/s0006-291x(84)80190-4	https://doi.org/10.1016/s0006-291x(84)80190-4	PROPN
fnp-3806	1444	14	glenner	glenner	PROPN
fnp-3806	1444	15	gg	gg	PROPN
fnp-3806	1444	16	,	,	PUNCT
fnp-3806	1444	17	wong	wong	PROPN
fnp-3806	1444	18	cw	cw	PROPN
fnp-3806	1444	19	,	,	PUNCT
fnp-3806	1444	20	quaranta	quaranta	PROPN
fnp-3806	1444	21	v	v	NOUN
fnp-3806	1444	22	,	,	PUNCT
fnp-3806	1444	23	et	et	PROPN
fnp-3806	1444	24	al	al	PROPN
fnp-3806	1444	25	.	.	PUNCT
fnp-3806	1445	1	the	the	DET
fnp-3806	1445	2	amyloid	amyloid	NOUN
fnp-3806	1445	3	deposits	deposit	NOUN
fnp-3806	1445	4	in	in	ADP
fnp-3806	1445	5	alzheimer	alzheimer	PROPN
fnp-3806	1445	6	's	's	PART
fnp-3806	1445	7	disease	disease	NOUN
fnp-3806	1445	8	:	:	PUNCT
fnp-3806	1445	9	their	their	PRON
fnp-3806	1445	10	nature	nature	NOUN
fnp-3806	1445	11	and	and	CCONJ
fnp-3806	1445	12	pathogenesis	pathogenesis	NOUN
fnp-3806	1445	13	.	.	PUNCT
fnp-3806	1446	1	appl	appl	PROPN
fnp-3806	1446	2	pathol	pathol	PROPN
fnp-3806	1446	3	1984	1984	NUM
fnp-3806	1446	4	;	;	PUNCT
fnp-3806	1446	5	12:357	12:357	NUM
fnp-3806	1446	6	-	-	PUNCT
fnp-3806	1446	7	369	369	NUM
fnp-3806	1446	8	.	.	PUNCT
fnp-3806	1447	1	pmid	pmid	NOUN
fnp-3806	1447	2	:	:	PUNCT
fnp-3806	1447	3	6242724	6242724	NUM
fnp-3806	1447	4	.	.	PUNCT
fnp-3806	1448	1	masters	master	NOUN
fnp-3806	1448	2	cl	cl	PROPN
fnp-3806	1448	3	,	,	PUNCT
fnp-3806	1448	4	simms	simms	PROPN
fnp-3806	1448	5	g	g	PROPN
fnp-3806	1448	6	,	,	PUNCT
fnp-3806	1448	7	weinman	weinman	ADJ
fnp-3806	1448	8	na	na	NOUN
fnp-3806	1448	9	,	,	PUNCT
fnp-3806	1448	10	et	et	PROPN
fnp-3806	1448	11	al	al	PROPN
fnp-3806	1448	12	.	.	PUNCT
fnp-3806	1448	13	amyloid	amyloid	PROPN
fnp-3806	1448	14	plaque	plaque	NOUN
fnp-3806	1448	15	core	core	NOUN
fnp-3806	1448	16	protein	protein	NOUN
fnp-3806	1448	17	in	in	ADP
fnp-3806	1448	18	alzheimer	alzheimer	NOUN
fnp-3806	1448	19	disease	disease	NOUN
fnp-3806	1448	20	and	and	CCONJ
fnp-3806	1448	21	down	down	ADP
fnp-3806	1448	22	syndrome	syndrome	NOUN
fnp-3806	1448	23	.	.	PUNCT
fnp-3806	1449	1	proc	proc	PROPN
fnp-3806	1449	2	nat	nat	PROPN
fnp-3806	1449	3	acad	acad	PROPN
fnp-3806	1449	4	sci	sci	PROPN
fnp-3806	1449	5	usa	usa	PROPN
fnp-3806	1449	6	1985	1985	NUM
fnp-3806	1449	7	;	;	PUNCT
fnp-3806	1449	8	82:4245	82:4245	X
fnp-3806	1449	9	-	-	SYM
fnp-3806	1449	10	4249	4249	NUM
fnp-3806	1449	11	.	.	PUNCT
fnp-3806	1450	1	https://doi.org/10.1073/pnas.82.12.4245	https://doi.org/10.1073/pnas.82.12.4245	PROPN
fnp-3806	1450	2	iwatsubo	iwatsubo	PROPN
fnp-3806	1450	3	t	t	PROPN
fnp-3806	1450	4	,	,	PUNCT
fnp-3806	1450	5	odaka	odaka	X
fnp-3806	1450	6	a	a	X
fnp-3806	1450	7	,	,	PUNCT
fnp-3806	1450	8	suzuki	suzuki	PROPN
fnp-3806	1450	9	n	n	CCONJ
fnp-3806	1450	10	,	,	PUNCT
fnp-3806	1450	11	et	et	PROPN
fnp-3806	1450	12	al	al	PROPN
fnp-3806	1450	13	.	.	PUNCT
fnp-3806	1450	14	visualization	visualization	NOUN
fnp-3806	1450	15	of	of	ADP
fnp-3806	1450	16	a	a	DET
fnp-3806	1450	17	beta	beta	NOUN
fnp-3806	1450	18	42(43	42(43	NOUN
fnp-3806	1450	19	)	)	PUNCT
fnp-3806	1450	20	and	and	CCONJ
fnp-3806	1450	21	a	a	DET
fnp-3806	1450	22	beta	beta	NOUN
fnp-3806	1450	23	40	40	NUM
fnp-3806	1450	24	in	in	ADP
fnp-3806	1450	25	senile	senile	ADJ
fnp-3806	1450	26	plaques	plaque	NOUN
fnp-3806	1450	27	with	with	ADP
fnp-3806	1450	28	end	end	NOUN
fnp-3806	1450	29	-	-	PUNCT
fnp-3806	1450	30	specific	specific	NOUN
fnp-3806	1450	31	a	a	DET
fnp-3806	1450	32	beta	beta	NOUN
fnp-3806	1450	33	monoclonals	monoclonal	NOUN
fnp-3806	1450	34	:	:	PUNCT
fnp-3806	1450	35	evidence	evidence	NOUN
fnp-3806	1450	36	that	that	SCONJ
fnp-3806	1450	37	an	an	DET
fnp-3806	1450	38	initially	initially	ADV
fnp-3806	1450	39	deposited	deposit	VERB
fnp-3806	1450	40	species	specie	NOUN
fnp-3806	1450	41	is	be	AUX
fnp-3806	1450	42	a	a	DET
fnp-3806	1450	43	beta	beta	NOUN
fnp-3806	1450	44	42(43	42(43	NOUN
fnp-3806	1450	45	)	)	PUNCT
fnp-3806	1450	46	.	.	PUNCT
fnp-3806	1451	1	neuron	neuron	PROPN
fnp-3806	1451	2	1994	1994	NUM
fnp-3806	1451	3	;	;	PUNCT
fnp-3806	1451	4	13:45	13:45	NUM
fnp-3806	1451	5	-	-	SYM
fnp-3806	1451	6	53	53	NUM
fnp-3806	1451	7	.	.	PUNCT
fnp-3806	1452	1	https://doi.org/10.1016/0896-6273(94)90458-8	https://doi.org/10.1016/0896-6273(94)90458-8	DET
fnp-3806	1452	2	masters	master	NOUN
fnp-3806	1452	3	cl	cl	PROPN
fnp-3806	1452	4	,	,	PUNCT
fnp-3806	1452	5	beyreuther	beyreuther	PROPN
fnp-3806	1452	6	k.	k.	PROPN
fnp-3806	1452	7	amyloid	amyloid	PROPN
fnp-3806	1452	8	-	-	PUNCT
fnp-3806	1452	9	β	β	NOUN
fnp-3806	1452	10	production	production	NOUN
fnp-3806	1452	11	.	.	PUNCT
fnp-3806	1453	1	in	in	ADP
fnp-3806	1453	2	:	:	PUNCT
fnp-3806	1453	3	dickson	dickson	PROPN
fnp-3806	1453	4	dw	dw	PROPN
fnp-3806	1453	5	,	,	PUNCT
fnp-3806	1453	6	weller	weller	PROPN
fnp-3806	1453	7	ro	ro	PROPN
fnp-3806	1453	8	,	,	PUNCT
fnp-3806	1453	9	eds	ed	NOUN
fnp-3806	1453	10	.	.	PUNCT
fnp-3806	1453	11	neurodegeneration	neurodegeneration	NOUN
fnp-3806	1453	12	:	:	PUNCT
fnp-3806	1453	13	the	the	DET
fnp-3806	1453	14	molecular	molecular	ADJ
fnp-3806	1453	15	pathology	pathology	NOUN
fnp-3806	1453	16	of	of	ADP
fnp-3806	1453	17	dementia	dementia	NOUN
fnp-3806	1453	18	and	and	CCONJ
fnp-3806	1453	19	movement	movement	NOUN
fnp-3806	1453	20	disorders	disorder	NOUN
fnp-3806	1453	21	,	,	PUNCT
fnp-3806	1453	22	2nd	2nd	ADJ
fnp-3806	1453	23	ed	ed	NOUN
fnp-3806	1453	24	.	.	PUNCT
fnp-3806	1454	1	blackwell	blackwell	PROPN
fnp-3806	1454	2	publishing	publishing	PROPN
fnp-3806	1454	3	co	co	NOUN
fnp-3806	1454	4	;	;	PUNCT
fnp-3806	1454	5	2011:92–6	2011:92–6	PROPN
fnp-3806	1454	6	.	.	PUNCT
fnp-3806	1455	1	lee	lee	PROPN
fnp-3806	1455	2	ms	ms	PROPN
fnp-3806	1455	3	,	,	PUNCT
fnp-3806	1455	4	kao	kao	PROPN
fnp-3806	1455	5	sc	sc	PROPN
fnp-3806	1455	6	,	,	PUNCT
fnp-3806	1455	7	lemere	lemere	PROPN
fnp-3806	1455	8	ca	can	AUX
fnp-3806	1455	9	,	,	PUNCT
fnp-3806	1455	10	et	et	PROPN
fnp-3806	1455	11	al	al	PROPN
fnp-3806	1455	12	.	.	PROPN
fnp-3806	1456	1	app	app	PROPN
fnp-3806	1456	2	processing	processing	NOUN
fnp-3806	1456	3	is	be	AUX
fnp-3806	1456	4	regulated	regulate	VERB
fnp-3806	1456	5	by	by	ADP
fnp-3806	1456	6	cytoplasmic	cytoplasmic	ADJ
fnp-3806	1456	7	phosphorylation	phosphorylation	NOUN
fnp-3806	1456	8	.	.	PUNCT
fnp-3806	1457	1	j	j	PROPN
fnp-3806	1457	2	cell	cell	NOUN
fnp-3806	1457	3	biol	biol	PROPN
fnp-3806	1457	4	2013;163:83	2013;163:83	NUM
fnp-3806	1457	5	-	-	SYM
fnp-3806	1457	6	95	95	NUM
fnp-3806	1457	7	.	.	PUNCT
fnp-3806	1458	1	https://doi.org/10.1083/jcb.200301115	https://doi.org/10.1083/jcb.200301115	PROPN
fnp-3806	1458	2	vassar	vassar	PROPN
fnp-3806	1458	3	r	r	PROPN
fnp-3806	1458	4	,	,	PUNCT
fnp-3806	1458	5	kovacs	kovacs	PROPN
fnp-3806	1458	6	dm	dm	PROPN
fnp-3806	1458	7	,	,	PUNCT
fnp-3806	1458	8	yan	yan	PROPN
fnp-3806	1459	1	r	r	NOUN
fnp-3806	1459	2	,	,	PUNCT
fnp-3806	1459	3	et	et	PROPN
fnp-3806	1459	4	al	al	PROPN
fnp-3806	1459	5	.	.	PUNCT
fnp-3806	1460	1	the	the	DET
fnp-3806	1460	2	beta	beta	NOUN
fnp-3806	1460	3	-	-	PUNCT
fnp-3806	1460	4	secretase	secretase	NOUN
fnp-3806	1460	5	enzyme	enzyme	NOUN
fnp-3806	1460	6	bace	bace	NOUN
fnp-3806	1460	7	in	in	ADP
fnp-3806	1460	8	health	health	PROPN
fnp-3806	1460	9	and	and	CCONJ
fnp-3806	1460	10	alzheimer	alzheimer	PROPN
fnp-3806	1460	11	's	's	PART
fnp-3806	1460	12	disease	disease	NOUN
fnp-3806	1460	13	:	:	PUNCT
fnp-3806	1460	14	regulation	regulation	NOUN
fnp-3806	1460	15	,	,	PUNCT
fnp-3806	1460	16	cell	cell	NOUN
fnp-3806	1460	17	biology	biology	NOUN
fnp-3806	1460	18	,	,	PUNCT
fnp-3806	1460	19	function	function	NOUN
fnp-3806	1460	20	,	,	PUNCT
fnp-3806	1460	21	and	and	CCONJ
fnp-3806	1460	22	therapeutic	therapeutic	ADJ
fnp-3806	1460	23	potential	potential	ADJ
fnp-3806	1460	24	j	j	PROPN
fnp-3806	1460	25	neurosci	neurosci	NOUN
fnp-3806	1460	26	2009;29:12787	2009;29:12787	NUM
fnp-3806	1460	27	-	-	SYM
fnp-3806	1460	28	12794	12794	NUM
fnp-3806	1460	29	.	.	PUNCT
fnp-3806	1461	1	https://doi.org/10.1523/jneurosci.3657-09.2009	https://doi.org/10.1523/jneurosci.3657-09.2009	PROPN
fnp-3806	1461	2	zhang	zhang	PROPN
fnp-3806	1461	3	x	x	PROPN
fnp-3806	1461	4	,	,	PUNCT
fnp-3806	1461	5	li	li	PROPN
fnp-3806	1461	6	y	y	PROPN
fnp-3806	1461	7	,	,	PUNCT
fnp-3806	1461	8	xu	xu	PROPN
fnp-3806	1462	1	h	h	PROPN
fnp-3806	1462	2	,	,	PUNCT
fnp-3806	1462	3	zhang	zhang	PROPN
fnp-3806	1462	4	yw	yw	PROPN
fnp-3806	1462	5	.	.	PUNCT
fnp-3806	1463	1	the	the	DET
fnp-3806	1463	2	gamma	gamma	NOUN
fnp-3806	1463	3	-	-	PUNCT
fnp-3806	1463	4	secretase	secretase	NOUN
fnp-3806	1463	5	complex	complex	NOUN
fnp-3806	1463	6	:	:	PUNCT
fnp-3806	1463	7	from	from	ADP
fnp-3806	1463	8	structure	structure	NOUN
fnp-3806	1463	9	to	to	PART
fnp-3806	1463	10	function	function	VERB
fnp-3806	1463	11	.	.	PUNCT
fnp-3806	1464	1	front	front	ADJ
fnp-3806	1464	2	cell	cell	NOUN
fnp-3806	1464	3	neurosci	neurosci	NOUN
fnp-3806	1464	4	2014;8:427	2014;8:427	NOUN
fnp-3806	1464	5	.	.	PUNCT
fnp-3806	1465	1	https://doi.org/10.3389/fncel.2014.00427	https://doi.org/10.3389/fncel.2014.00427	PROPN
fnp-3806	1465	2	barthet	barthet	NOUN
fnp-3806	1465	3	g	g	NOUN
fnp-3806	1465	4	,	,	PUNCT
fnp-3806	1465	5	georgakopoulos	georgakopoulos	PROPN
fnp-3806	1465	6	a	a	PROPN
fnp-3806	1465	7	,	,	PUNCT
fnp-3806	1465	8	robakis	robakis	PROPN
fnp-3806	1465	9	nk	nk	PROPN
fnp-3806	1465	10	.	.	PUNCT
fnp-3806	1465	11	cellular	cellular	ADJ
fnp-3806	1465	12	mechanisms	mechanism	NOUN
fnp-3806	1465	13	of	of	ADP
fnp-3806	1465	14	γ	γ	NOUN
fnp-3806	1465	15	-	-	ADJ
fnp-3806	1465	16	secretase	secretase	ADJ
fnp-3806	1465	17	substrate	substrate	NOUN
fnp-3806	1465	18	selection	selection	NOUN
fnp-3806	1465	19	,	,	PUNCT
fnp-3806	1465	20	processing	processing	NOUN
fnp-3806	1465	21	and	and	CCONJ
fnp-3806	1465	22	toxicity	toxicity	NOUN
fnp-3806	1465	23	.	.	PUNCT
fnp-3806	1466	1	prog	prog	PROPN
fnp-3806	1466	2	neurobiol	neurobiol	PROPN
fnp-3806	1466	3	2012;98:166	2012;98:166	PROPN
fnp-3806	1466	4	-	-	SYM
fnp-3806	1466	5	175	175	NUM
fnp-3806	1466	6	.	.	PUNCT
fnp-3806	1467	1	https://doi.org/10.1016/j.pneurobio.2012.05.006	https://doi.org/10.1016/j.pneurobio.2012.05.006	ADJ
fnp-3806	1467	2	wolfe	wolfe	PROPN
fnp-3806	1467	3	ms	ms	PROPN
fnp-3806	1467	4	.	.	PROPN
fnp-3806	1467	5	structure	structure	NOUN
fnp-3806	1467	6	and	and	CCONJ
fnp-3806	1467	7	function	function	NOUN
fnp-3806	1467	8	of	of	ADP
fnp-3806	1467	9	the	the	DET
fnp-3806	1467	10	γ	γ	PROPN
fnp-3806	1467	11	-	-	PUNCT
fnp-3806	1467	12	secretase	secretase	ADJ
fnp-3806	1467	13	complex	complex	NOUN
fnp-3806	1467	14	.	.	PUNCT
fnp-3806	1468	1	biochemistry	biochemistry	NOUN
fnp-3806	1468	2	2019;58:2953	2019;58:2953	NUM
fnp-3806	1468	3	-	-	SYM
fnp-3806	1468	4	2966	2966	NUM
fnp-3806	1468	5	.	.	PUNCT
fnp-3806	1469	1	https://doi.org/10.1021/acs.biochem	https://doi.org/10.1021/acs.biochem	PROPN
fnp-3806	1469	2	9b00401	9b00401	PROPN
fnp-3806	1469	3	.	.	PUNCT
fnp-3806	1470	1	beyreuther	beyreuther	PROPN
fnp-3806	1470	2	k	k	PROPN
fnp-3806	1470	3	,	,	PUNCT
fnp-3806	1470	4	masters	master	NOUN
fnp-3806	1470	5	cl	cl	NOUN
fnp-3806	1470	6	.	.	PUNCT
fnp-3806	1470	7	amyloid	amyloid	NOUN
fnp-3806	1470	8	precursor	precursor	NOUN
fnp-3806	1470	9	protein	protein	NOUN
fnp-3806	1470	10	(	(	PUNCT
fnp-3806	1470	11	app	app	NOUN
fnp-3806	1470	12	)	)	PUNCT
fnp-3806	1470	13	and	and	CCONJ
fnp-3806	1470	14	beta	beta	NOUN
fnp-3806	1470	15	a4	a4	NOUN
fnp-3806	1470	16	amyloid	amyloid	NOUN
fnp-3806	1470	17	in	in	ADP
fnp-3806	1470	18	the	the	DET
fnp-3806	1470	19	etiology	etiology	NOUN
fnp-3806	1470	20	of	of	ADP
fnp-3806	1470	21	alzheimer	alzheimer	PROPN
fnp-3806	1470	22	's	's	PART
fnp-3806	1470	23	disease	disease	NOUN
fnp-3806	1470	24	:	:	PUNCT
fnp-3806	1470	25	precursor	precursor	NOUN
fnp-3806	1470	26	-	-	PUNCT
fnp-3806	1470	27	product	product	NOUN
fnp-3806	1470	28	relationships	relationship	NOUN
fnp-3806	1470	29	in	in	ADP
fnp-3806	1470	30	the	the	DET
fnp-3806	1470	31	derangement	derangement	NOUN
fnp-3806	1470	32	of	of	ADP
fnp-3806	1470	33	neuronal	neuronal	ADJ
fnp-3806	1470	34	function	function	NOUN
fnp-3806	1470	35	.	.	PUNCT
fnp-3806	1471	1	brain	brain	NOUN
fnp-3806	1471	2	pathol	pathol	NOUN
fnp-3806	1471	3	1991;1:241	1991;1:241	PROPN
fnp-3806	1471	4	-	-	SYM
fnp-3806	1471	5	251	251	NUM
fnp-3806	1471	6	.	.	PUNCT
fnp-3806	1472	1	https://doi.org/10.1111/j.1750-3639.1991.tb00667.x	https://doi.org/10.1111/j.1750-3639.1991.tb00667.x	PROPN
fnp-3806	1472	2	masters	master	NOUN
fnp-3806	1472	3	cl	cl	PROPN
fnp-3806	1472	4	,	,	PUNCT
fnp-3806	1472	5	beyreuther	beyreuther	PROPN
fnp-3806	1472	6	k.	k.	PROPN
fnp-3806	1472	7	alzheimer	alzheimer	PROPN
fnp-3806	1472	8	's	's	PART
fnp-3806	1472	9	centennial	centennial	NOUN
fnp-3806	1472	10	legacy	legacy	NOUN
fnp-3806	1472	11	:	:	PUNCT
fnp-3806	1472	12	prospects	prospect	NOUN
fnp-3806	1472	13	for	for	ADP
fnp-3806	1472	14	rational	rational	ADJ
fnp-3806	1472	15	therapeutic	therapeutic	ADJ
fnp-3806	1472	16	intervention	intervention	NOUN
fnp-3806	1472	17	targeting	target	VERB
fnp-3806	1472	18	the	the	DET
fnp-3806	1472	19	abeta	abeta	PROPN
fnp-3806	1472	20	amyloid	amyloid	NOUN
fnp-3806	1472	21	pathway	pathway	NOUN
fnp-3806	1472	22	.	.	PUNCT
fnp-3806	1473	1	brain	brain	NOUN
fnp-3806	1473	2	2006;129:2823	2006;129:2823	NUM
fnp-3806	1473	3	-	-	SYM
fnp-3806	1473	4	2839	2839	NUM
fnp-3806	1473	5	.	.	PUNCT
fnp-3806	1474	1	https://doi.org/10.1093/brain/awl251	https://doi.org/10.1093/brain/awl251	PROPN
fnp-3806	1474	2	masters	master	NOUN
fnp-3806	1474	3	cl	cl	PROPN
fnp-3806	1474	4	,	,	PUNCT
fnp-3806	1474	5	selkoe	selkoe	ADJ
fnp-3806	1474	6	dj	dj	NOUN
fnp-3806	1474	7	.	.	PUNCT
fnp-3806	1475	1	biochemistry	biochemistry	NOUN
fnp-3806	1475	2	of	of	ADP
fnp-3806	1475	3	amyloid	amyloid	NOUN
fnp-3806	1475	4	β	β	NOUN
fnp-3806	1475	5	-	-	NOUN
fnp-3806	1475	6	protein	protein	NOUN
fnp-3806	1475	7	and	and	CCONJ
fnp-3806	1475	8	amyloid	amyloid	NOUN
fnp-3806	1475	9	deposits	deposit	NOUN
fnp-3806	1475	10	in	in	ADP
fnp-3806	1475	11	alzheimer	alzheimer	PROPN
fnp-3806	1475	12	disease	disease	PROPN
fnp-3806	1475	13	.	.	PUNCT
fnp-3806	1476	1	cold	cold	ADJ
fnp-3806	1476	2	spring	spring	NOUN
fnp-3806	1476	3	harb	harb	PROPN
fnp-3806	1476	4	perspect	perspect	PROPN
fnp-3806	1476	5	med	med	PROPN
fnp-3806	1476	6	2012;2	2012;2	NUM
fnp-3806	1476	7	:	:	PUNCT
fnp-3806	1476	8	a006262	a006262	PROPN
fnp-3806	1476	9	.	.	PUNCT
fnp-3806	1477	1	https://doi.org/10.1101/cshperspect.a006262	https://doi.org/10.1101/cshperspect.a006262	PROPN
fnp-3806	1477	2	chen	chen	PROPN
fnp-3806	1477	3	gf	gf	PROPN
fnp-3806	1477	4	,	,	PUNCT
fnp-3806	1477	5	xu	xu	PROPN
fnp-3806	1477	6	th	th	PROPN
fnp-3806	1477	7	,	,	PUNCT
fnp-3806	1477	8	yan	yan	PROPN
fnp-3806	1477	9	y	y	PROPN
fnp-3806	1477	10	,	,	PUNCT
fnp-3806	1477	11	et	et	PROPN
fnp-3806	1477	12	al	al	PROPN
fnp-3806	1477	13	.	.	PUNCT
fnp-3806	1477	14	amyloid	amyloid	PROPN
fnp-3806	1477	15	beta	beta	NOUN
fnp-3806	1477	16	:	:	PUNCT
fnp-3806	1477	17	structure	structure	NOUN
fnp-3806	1477	18	,	,	PUNCT
fnp-3806	1477	19	biology	biology	NOUN
fnp-3806	1477	20	and	and	CCONJ
fnp-3806	1477	21	structure	structure	NOUN
fnp-3806	1477	22	-	-	PUNCT
fnp-3806	1477	23	based	base	VERB
fnp-3806	1477	24	therapeutic	therapeutic	ADJ
fnp-3806	1477	25	treatment	treatment	NOUN
fnp-3806	1477	26	.	.	PUNCT
fnp-3806	1478	1	acta	acta	PROPN
fnp-3806	1478	2	pharmacol	pharmacol	PROPN
fnp-3806	1478	3	sin	sin	PROPN
fnp-3806	1478	4	2017;38:1205	2017;38:1205	NUM
fnp-3806	1478	5	-	-	SYM
fnp-3806	1478	6	1235	1235	NUM
fnp-3806	1478	7	.	.	PUNCT
fnp-3806	1479	1	https://doi.org/10.1038/aps.2017.28	https://doi.org/10.1038/aps.2017.28	NOUN
fnp-3806	1479	2	fassbender	fassbender	PROPN
fnp-3806	1479	3	k	k	PROPN
fnp-3806	1479	4	,	,	PUNCT
fnp-3806	1479	5	simons	simons	PROPN
fnp-3806	1479	6	m	m	PROPN
fnp-3806	1479	7	,	,	PUNCT
fnp-3806	1479	8	bergmann	bergmann	PROPN
fnp-3806	1479	9	c	c	AUX
fnp-3806	1479	10	,	,	PUNCT
fnp-3806	1480	1	et	et	PROPN
fnp-3806	1480	2	al	al	PROPN
fnp-3806	1480	3	.	.	PROPN
fnp-3806	1480	4	simvastatin	simvastatin	PROPN
fnp-3806	1480	5	strongly	strongly	ADV
fnp-3806	1480	6	reduces	reduce	VERB
fnp-3806	1480	7	levels	level	NOUN
fnp-3806	1480	8	of	of	ADP
fnp-3806	1480	9	alzheimer	alzheimer	PROPN
fnp-3806	1480	10	's	's	PART
fnp-3806	1480	11	disease	disease	NOUN
fnp-3806	1480	12	beta	beta	NOUN
fnp-3806	1480	13	-	-	PUNCT
fnp-3806	1480	14	amyloid	amyloid	NOUN
fnp-3806	1480	15	peptides	peptide	NOUN
fnp-3806	1480	16	abeta	abeta	VERB
fnp-3806	1480	17	42	42	NUM
fnp-3806	1480	18	and	and	CCONJ
fnp-3806	1480	19	abeta	abeta	NOUN
fnp-3806	1480	20	40	40	NUM
fnp-3806	1480	21	in	in	ADP
fnp-3806	1480	22	vitro	vitro	X
fnp-3806	1480	23	and	and	CCONJ
fnp-3806	1480	24	in	in	ADP
fnp-3806	1480	25	vivo	vivo	NOUN
fnp-3806	1480	26	.	.	PUNCT
fnp-3806	1481	1	proc	proc	PROPN
fnp-3806	1481	2	natl	natl	PROPN
fnp-3806	1481	3	acad	acad	PROPN
fnp-3806	1481	4	sci	sci	PROPN
fnp-3806	1481	5	usa	usa	PROPN
fnp-3806	1481	6	2001;98:5856	2001;98:5856	PROPN
fnp-3806	1481	7	-	-	PROPN
fnp-3806	1481	8	5861	5861	NUM
fnp-3806	1481	9	.	.	PUNCT
fnp-3806	1482	1	https://doi.org/10.1073/pnas.081620098	https://doi.org/10.1073/pnas.081620098	PROPN
fnp-3806	1482	2	wang	wang	PROPN
fnp-3806	1482	3	h	h	PROPN
fnp-3806	1482	4	,	,	PUNCT
fnp-3806	1482	5	kulas	kulas	PROPN
fnp-3806	1482	6	ja	ja	PROPN
fnp-3806	1482	7	,	,	PUNCT
fnp-3806	1482	8	wang	wang	PROPN
fnp-3806	1482	9	c	c	PROPN
fnp-3806	1482	10	,	,	PUNCT
fnp-3806	1482	11	et	et	PROPN
fnp-3806	1482	12	al	al	PROPN
fnp-3806	1482	13	.	.	PUNCT
fnp-3806	1483	1	regulation	regulation	NOUN
fnp-3806	1483	2	of	of	ADP
fnp-3806	1483	3	beta	beta	NOUN
fnp-3806	1483	4	-	-	PUNCT
fnp-3806	1483	5	amyloid	amyloid	NOUN
fnp-3806	1483	6	production	production	NOUN
fnp-3806	1483	7	in	in	ADP
fnp-3806	1483	8	neurons	neuron	NOUN
fnp-3806	1483	9	by	by	ADP
fnp-3806	1483	10	astrocyte	astrocyte	NOUN
fnp-3806	1483	11	-	-	PUNCT
fnp-3806	1483	12	derived	derive	VERB
fnp-3806	1483	13	cholesterol	cholesterol	NOUN
fnp-3806	1483	14	.	.	PUNCT
fnp-3806	1484	1	proc	proc	PROPN
fnp-3806	1484	2	natl	natl	PROPN
fnp-3806	1484	3	acad	acad	PROPN
fnp-3806	1484	4	sci	sci	PROPN
fnp-3806	1484	5	usa	usa	PROPN
fnp-3806	1484	6	2021;118	2021;118	NUM
fnp-3806	1484	7	:	:	PUNCT
fnp-3806	1484	8	e2102191118	e2102191118	NOUN
fnp-3806	1484	9	.	.	PUNCT
fnp-3806	1484	10	https://doi.org/10.1073/pnas.2102191118	https://doi.org/10.1073/pnas.2102191118	PROPN
fnp-3806	1484	11	ricciarelli	ricciarelli	PROPN
fnp-3806	1484	12	r	r	PROPN
fnp-3806	1484	13	,	,	PUNCT
fnp-3806	1484	14	fedele	fedele	PROPN
fnp-3806	1484	15	e.	e.	PROPN
fnp-3806	1484	16	camp	camp	PROPN
fnp-3806	1484	17	,	,	PUNCT
fnp-3806	1484	18	cgmp	cgmp	PROPN
fnp-3806	1484	19	and	and	CCONJ
fnp-3806	1484	20	amyloid	amyloid	NOUN
fnp-3806	1484	21	β	β	NOUN
fnp-3806	1484	22	:	:	PUNCT
fnp-3806	1484	23	three	three	NUM
fnp-3806	1484	24	ideal	ideal	ADJ
fnp-3806	1484	25	partners	partner	NOUN
fnp-3806	1484	26	for	for	ADP
fnp-3806	1484	27	memory	memory	NOUN
fnp-3806	1484	28	formation	formation	NOUN
fnp-3806	1484	29	.	.	PUNCT
fnp-3806	1485	1	trends	trend	NOUN
fnp-3806	1485	2	neurosci	neurosci	VERB
fnp-3806	1485	3	2018;41:255	2018;41:255	NOUN
fnp-3806	1485	4	-	-	SYM
fnp-3806	1485	5	266	266	NUM
fnp-3806	1485	6	.	.	PUNCT
fnp-3806	1486	1	https://doi.org/10.1016/j.tins.2018.02.001	https://doi.org/10.1016/j.tins.2018.02.001	ADJ
fnp-3806	1486	2	eckman	eckman	NOUN
fnp-3806	1486	3	ea	ea	PROPN
fnp-3806	1486	4	,	,	PUNCT
fnp-3806	1486	5	eckman	eckman	PROPN
fnp-3806	1486	6	cb	cb	PROPN
fnp-3806	1486	7	.	.	PROPN
fnp-3806	1486	8	abeta	abeta	PROPN
fnp-3806	1486	9	-	-	PUNCT
fnp-3806	1486	10	degrading	degrade	VERB
fnp-3806	1486	11	enzymes	enzyme	NOUN
fnp-3806	1486	12	:	:	PUNCT
fnp-3806	1486	13	modulators	modulator	NOUN
fnp-3806	1486	14	of	of	ADP
fnp-3806	1486	15	alzheimer	alzheimer	PROPN
fnp-3806	1486	16	's	's	PART
fnp-3806	1486	17	disease	disease	NOUN
fnp-3806	1486	18	pathogenesis	pathogenesis	NOUN
fnp-3806	1486	19	and	and	CCONJ
fnp-3806	1486	20	targets	target	NOUN
fnp-3806	1486	21	for	for	ADP
fnp-3806	1486	22	therapeutic	therapeutic	ADJ
fnp-3806	1486	23	intervention	intervention	NOUN
fnp-3806	1486	24	.	.	PUNCT
fnp-3806	1487	1	biochem	biochem	PROPN
fnp-3806	1487	2	soc	soc	PROPN
fnp-3806	1487	3	trans	tran	VERB
fnp-3806	1487	4	2005;33:1101	2005;33:1101	PROPN
fnp-3806	1487	5	-	-	PUNCT
fnp-3806	1487	6	1105	1105	NUM
fnp-3806	1487	7	.	.	PUNCT
fnp-3806	1488	1	https://doi.org/10.1042/bst20051101	https://doi.org/10.1042/bst20051101	NOUN
fnp-3806	1488	2	miners	miner	NOUN
fnp-3806	1488	3	js	js	PROPN
fnp-3806	1488	4	,	,	PUNCT
fnp-3806	1488	5	baig	baig	PROPN
fnp-3806	1488	6	s	s	PROPN
fnp-3806	1488	7	,	,	PUNCT
fnp-3806	1488	8	palmer	palmer	PROPN
fnp-3806	1488	9	j	j	PROPN
fnp-3806	1488	10	,	,	PUNCT
fnp-3806	1488	11	et	et	PROPN
fnp-3806	1488	12	al	al	PROPN
fnp-3806	1488	13	.	.	PUNCT
fnp-3806	1488	14	abeta	abeta	PROPN
fnp-3806	1488	15	-	-	PUNCT
fnp-3806	1488	16	degrading	degrade	VERB
fnp-3806	1488	17	enzymes	enzyme	NOUN
fnp-3806	1488	18	in	in	ADP
fnp-3806	1488	19	alzheimer	alzheimer	PROPN
fnp-3806	1488	20	's	's	PART
fnp-3806	1488	21	disease	disease	NOUN
fnp-3806	1488	22	.	.	PUNCT
fnp-3806	1489	1	brain	brain	NOUN
fnp-3806	1489	2	pathol	pathol	NOUN
fnp-3806	1489	3	2008;18:240	2008;18:240	NUM
fnp-3806	1489	4	-	-	SYM
fnp-3806	1489	5	252	252	NUM
fnp-3806	1489	6	.	.	PUNCT
fnp-3806	1490	1	https://doi.org/10.1111/j.1750-3639.2008.00132.x	https://doi.org/10.1111/j.1750-3639.2008.00132.x	PROPN
fnp-3806	1490	2	love	love	PROPN
fnp-3806	1490	3	s	s	PROPN
fnp-3806	1490	4	,	,	PUNCT
fnp-3806	1490	5	miners	miner	NOUN
fnp-3806	1490	6	s	s	PROPN
fnp-3806	1490	7	,	,	PUNCT
fnp-3806	1490	8	palmer	palmer	PROPN
fnp-3806	1490	9	j	j	PROPN
fnp-3806	1490	10	,	,	PUNCT
fnp-3806	1490	11	et	et	PROPN
fnp-3806	1490	12	al	al	PROPN
fnp-3806	1490	13	.	.	PUNCT
fnp-3806	1491	1	insights	insight	NOUN
fnp-3806	1491	2	into	into	ADP
fnp-3806	1491	3	the	the	DET
fnp-3806	1491	4	pathogenesis	pathogenesis	NOUN
fnp-3806	1491	5	and	and	CCONJ
fnp-3806	1491	6	pathogenicity	pathogenicity	NOUN
fnp-3806	1491	7	of	of	ADP
fnp-3806	1491	8	cerebral	cerebral	ADJ
fnp-3806	1491	9	amyloid	amyloid	NOUN
fnp-3806	1491	10	angiopathy	angiopathy	NOUN
fnp-3806	1491	11	.	.	PUNCT
fnp-3806	1492	1	front	front	NOUN
fnp-3806	1492	2	biosci	biosci	PROPN
fnp-3806	1492	3	2009;14:4778	2009;14:4778	PROPN
fnp-3806	1492	4	-	-	SYM
fnp-3806	1492	5	4792	4792	NUM
fnp-3806	1492	6	.	.	PUNCT
fnp-3806	1493	1	https://doi.org/10.2741/3567	https://doi.org/10.2741/3567	PROPN
fnp-3806	1493	2	bell	bell	PROPN
fnp-3806	1493	3	rd	rd	PROPN
fnp-3806	1493	4	,	,	PUNCT
fnp-3806	1493	5	zlokovic	zlokovic	PROPN
fnp-3806	1493	6	bv	bv	PROPN
fnp-3806	1493	7	.	.	PROPN
fnp-3806	1493	8	neurovascular	neurovascular	ADJ
fnp-3806	1493	9	mechanisms	mechanism	NOUN
fnp-3806	1493	10	and	and	CCONJ
fnp-3806	1493	11	blood	blood	NOUN
fnp-3806	1493	12	-	-	PUNCT
fnp-3806	1493	13	brain	brain	NOUN
fnp-3806	1493	14	barrier	barrier	NOUN
fnp-3806	1493	15	disorder	disorder	NOUN
fnp-3806	1493	16	in	in	ADP
fnp-3806	1493	17	alzheimer	alzheimer	PROPN
fnp-3806	1493	18	’s	’s	PART
fnp-3806	1493	19	disease	disease	NOUN
fnp-3806	1493	20	.	.	PUNCT
fnp-3806	1494	1	acta	acta	PROPN
fnp-3806	1494	2	neuropathol	neuropathol	PROPN
fnp-3806	1494	3	2009;118:103	2009;118:103	NUM
fnp-3806	1494	4	-	-	SYM
fnp-3806	1494	5	113	113	NUM
fnp-3806	1494	6	.	.	PUNCT
fnp-3806	1495	1	https://doi.org/10.1007/s00401-009-0522-3	https://doi.org/10.1007/s00401-009-0522-3	NUM
fnp-3806	1495	2	miners	miner	NOUN
fnp-3806	1495	3	js	js	PROPN
fnp-3806	1495	4	,	,	PUNCT
fnp-3806	1495	5	baig	baig	PROPN
fnp-3806	1495	6	s	s	PROPN
fnp-3806	1495	7	,	,	PUNCT
fnp-3806	1495	8	tayler	tayler	PROPN
fnp-3806	1495	9	h	h	NOUN
fnp-3806	1495	10	,	,	PUNCT
fnp-3806	1495	11	et	et	PROPN
fnp-3806	1495	12	al	al	PROPN
fnp-3806	1495	13	.	.	PROPN
fnp-3806	1495	14	neprilysin	neprilysin	PROPN
fnp-3806	1495	15	and	and	CCONJ
fnp-3806	1495	16	insulin	insulin	NOUN
fnp-3806	1495	17	-	-	PUNCT
fnp-3806	1495	18	degrading	degrade	VERB
fnp-3806	1495	19	enzyme	enzyme	NOUN
fnp-3806	1495	20	levels	level	NOUN
fnp-3806	1495	21	are	be	AUX
fnp-3806	1495	22	increased	increase	VERB
fnp-3806	1495	23	in	in	ADP
fnp-3806	1495	24	alzheimer	alzheimer	PROPN
fnp-3806	1495	25	disease	disease	NOUN
fnp-3806	1495	26	in	in	ADP
fnp-3806	1495	27	relation	relation	NOUN
fnp-3806	1495	28	to	to	ADP
fnp-3806	1495	29	disease	disease	NOUN
fnp-3806	1495	30	severity	severity	NOUN
fnp-3806	1495	31	.	.	PUNCT
fnp-3806	1496	1	j	j	PROPN
fnp-3806	1496	2	neuropathol	neuropathol	PROPN
fnp-3806	1496	3	exp	exp	PROPN
fnp-3806	1496	4	neurol	neurol	PROPN
fnp-3806	1496	5	2009;68:902	2009;68:902	PROPN
fnp-3806	1496	6	-	-	SYM
fnp-3806	1496	7	914	914	NUM
fnp-3806	1496	8	.	.	PUNCT
fnp-3806	1497	1	https://doi.org/10.1097/nen.0b013e3181afe475	https://doi.org/10.1097/nen.0b013e3181afe475	PROPN
fnp-3806	1497	2	zlokovic	zlokovic	PROPN
fnp-3806	1497	3	bv	bv	PROPN
fnp-3806	1497	4	,	,	PUNCT
fnp-3806	1497	5	deane	deane	PROPN
fnp-3806	1497	6	r	r	PROPN
fnp-3806	1497	7	,	,	PUNCT
fnp-3806	1497	8	sagare	sagare	PROPN
fnp-3806	1497	9	ap	ap	PROPN
fnp-3806	1497	10	,	,	PUNCT
fnp-3806	1497	11	et	et	PROPN
fnp-3806	1497	12	al	al	PROPN
fnp-3806	1497	13	.	.	PUNCT
fnp-3806	1497	14	low	low	ADJ
fnp-3806	1497	15	-	-	PUNCT
fnp-3806	1497	16	density	density	NOUN
fnp-3806	1497	17	lipoprotein	lipoprotein	ADJ
fnp-3806	1497	18	receptor	receptor	NOUN
fnp-3806	1497	19	-	-	PUNCT
fnp-3806	1497	20	related	relate	VERB
fnp-3806	1497	21	protein-1	protein-1	NOUN
fnp-3806	1497	22	:	:	PUNCT
fnp-3806	1497	23	a	a	DET
fnp-3806	1497	24	serial	serial	ADJ
fnp-3806	1497	25	clearance	clearance	NOUN
fnp-3806	1497	26	homeostatic	homeostatic	ADJ
fnp-3806	1497	27	mechanism	mechanism	NOUN
fnp-3806	1497	28	controlling	control	VERB
fnp-3806	1497	29	alzheimer	alzheimer	PROPN
fnp-3806	1497	30	's	's	PART
fnp-3806	1497	31	amyloid	amyloid	NOUN
fnp-3806	1497	32	beta	beta	NOUN
fnp-3806	1497	33	-	-	PUNCT
fnp-3806	1497	34	peptide	peptide	NOUN
fnp-3806	1497	35	elimination	elimination	NOUN
fnp-3806	1497	36	from	from	ADP
fnp-3806	1497	37	the	the	DET
fnp-3806	1497	38	brain	brain	NOUN
fnp-3806	1497	39	.	.	PUNCT
fnp-3806	1498	1	j	j	PROPN
fnp-3806	1498	2	neurochem	neurochem	PROPN
fnp-3806	1498	3	2010;115:1077	2010;115:1077	NUM
fnp-3806	1498	4	-	-	SYM
fnp-3806	1498	5	1089	1089	NUM
fnp-3806	1498	6	.	.	PUNCT
fnp-3806	1499	1	https://doi.org/10.1111/j.1471-4159.2010.07002.x	https://doi.org/10.1111/j.1471-4159.2010.07002.x	NOUN
fnp-3806	1499	2	pacheco	pacheco	PROPN
fnp-3806	1499	3	-	-	PUNCT
fnp-3806	1499	4	quinto	quinto	PROPN
fnp-3806	1499	5	j	j	PROPN
fnp-3806	1499	6	,	,	PUNCT
fnp-3806	1499	7	clausen	clausen	PROPN
fnp-3806	1499	8	d	d	PROPN
fnp-3806	1499	9	,	,	PUNCT
fnp-3806	1499	10	pérez	pérez	NOUN
fnp-3806	1499	11	-	-	PUNCT
fnp-3806	1499	12	gonzález	gonzález	PROPN
fnp-3806	1499	13	r	r	NOUN
fnp-3806	1499	14	,	,	PUNCT
fnp-3806	1499	15	et	et	PROPN
fnp-3806	1499	16	al	al	PROPN
fnp-3806	1499	17	.	.	PROPN
fnp-3806	1499	18	intracellular	intracellular	ADJ
fnp-3806	1499	19	metalloprotease	metalloprotease	NOUN
fnp-3806	1499	20	activity	activity	NOUN
fnp-3806	1499	21	controls	control	VERB
fnp-3806	1499	22	intraneuronal	intraneuronal	ADJ
fnp-3806	1499	23	aβ	aβ	NOUN
fnp-3806	1499	24	aggregation	aggregation	NOUN
fnp-3806	1499	25	and	and	CCONJ
fnp-3806	1499	26	limits	limit	VERB
fnp-3806	1499	27	secretion	secretion	NOUN
fnp-3806	1499	28	of	of	ADP
fnp-3806	1499	29	aβ	aβ	NOUN
fnp-3806	1499	30	via	via	ADP
fnp-3806	1499	31	exosomes	exosome	NOUN
fnp-3806	1499	32	.	.	PUNCT
fnp-3806	1500	1	faseb	faseb	PROPN
fnp-3806	1500	2	j	j	PROPN
fnp-3806	1500	3	2019;33:3758	2019;33:3758	NUM
fnp-3806	1500	4	-	-	SYM
fnp-3806	1500	5	3771	3771	NUM
fnp-3806	1500	6	.	.	PUNCT
fnp-3806	1501	1	https://doi.org/10.1096/fj.201801319r	https://doi.org/10.1096/fj.201801319r	PROPN
fnp-3806	1501	2	weller	weller	PROPN
fnp-3806	1501	3	ro	ro	PROPN
fnp-3806	1501	4	,	,	PUNCT
fnp-3806	1501	5	djuanda	djuanda	NOUN
fnp-3806	1501	6	e	e	PROPN
fnp-3806	1501	7	,	,	PUNCT
fnp-3806	1501	8	yow	yow	PROPN
fnp-3806	1501	9	hy	hy	PROPN
fnp-3806	1501	10	,	,	PUNCT
fnp-3806	1501	11	et	et	PROPN
fnp-3806	1501	12	al	al	PROPN
fnp-3806	1501	13	.	.	PUNCT
fnp-3806	1502	1	lymphatic	lymphatic	ADJ
fnp-3806	1502	2	drainage	drainage	NOUN
fnp-3806	1502	3	of	of	ADP
fnp-3806	1502	4	the	the	DET
fnp-3806	1502	5	brain	brain	NOUN
fnp-3806	1502	6	and	and	CCONJ
fnp-3806	1502	7	the	the	DET
fnp-3806	1502	8	pathophysiology	pathophysiology	NOUN
fnp-3806	1502	9	of	of	ADP
fnp-3806	1502	10	neurological	neurological	ADJ
fnp-3806	1502	11	disease	disease	NOUN
fnp-3806	1502	12	.	.	PUNCT
fnp-3806	1503	1	acta	acta	PROPN
fnp-3806	1503	2	neuropathol	neuropathol	PROPN
fnp-3806	1503	3	2009;117:1	2009;117:1	NUM
fnp-3806	1503	4	-	-	SYM
fnp-3806	1503	5	14	14	NUM
fnp-3806	1503	6	.	.	PUNCT
fnp-3806	1504	1	https://doi.org/10.1007/s00401-008-0457-0	https://doi.org/10.1007/s00401-008-0457-0	NUM
fnp-3806	1504	2	gouveia	gouveia	NOUN
fnp-3806	1504	3	-	-	PUNCT
fnp-3806	1504	4	freitas	freitas	PROPN
fnp-3806	1504	5	k	k	NOUN
fnp-3806	1504	6	,	,	PUNCT
fnp-3806	1504	7	bastos	bastos	PROPN
fnp-3806	1504	8	-	-	PUNCT
fnp-3806	1504	9	leite	leite	PROPN
fnp-3806	1504	10	aj	aj	PROPN
fnp-3806	1504	11	.	.	PROPN
fnp-3806	1505	1	perivascular	perivascular	ADJ
fnp-3806	1505	2	spaces	space	NOUN
fnp-3806	1505	3	and	and	CCONJ
fnp-3806	1505	4	brain	brain	NOUN
fnp-3806	1505	5	waste	waste	NOUN
fnp-3806	1505	6	clearance	clearance	NOUN
fnp-3806	1505	7	systems	system	NOUN
fnp-3806	1505	8	:	:	PUNCT
fnp-3806	1505	9	relevance	relevance	NOUN
fnp-3806	1505	10	for	for	ADP
fnp-3806	1505	11	neurodegenerative	neurodegenerative	ADJ
fnp-3806	1505	12	and	and	CCONJ
fnp-3806	1505	13	cerebrovascular	cerebrovascular	ADJ
fnp-3806	1505	14	pathology	pathology	NOUN
fnp-3806	1505	15	.	.	PUNCT
fnp-3806	1506	1	neuroradiology	neuroradiology	NOUN
fnp-3806	1506	2	2021;63:1581	2021;63:1581	PROPN
fnp-3806	1506	3	-	-	SYM
fnp-3806	1506	4	1597	1597	NUM
fnp-3806	1506	5	.	.	PUNCT
fnp-3806	1507	1	https://doi.org/10.1007/s00234-021-02718-7	https://doi.org/10.1007/s00234-021-02718-7	NOUN
fnp-3806	1507	2	foster	foster	VERB
fnp-3806	1507	3	em	em	PRON
fnp-3806	1507	4	,	,	PUNCT
fnp-3806	1507	5	dangla	dangla	PROPN
fnp-3806	1507	6	-	-	PUNCT
fnp-3806	1507	7	valls	vall	VERB
fnp-3806	1507	8	a	a	PRON
fnp-3806	1507	9	,	,	PUNCT
fnp-3806	1507	10	lovestone	lovestone	NOUN
fnp-3806	1507	11	s	s	PART
fnp-3806	1507	12	,	,	PUNCT
fnp-3806	1507	13	et	et	PROPN
fnp-3806	1507	14	al	al	PROPN
fnp-3806	1507	15	.	.	PROPN
fnp-3806	1507	16	clusterin	clusterin	PROPN
fnp-3806	1507	17	in	in	ADP
fnp-3806	1507	18	alzheimer	alzheimer	PROPN
fnp-3806	1507	19	's	's	PART
fnp-3806	1507	20	disease	disease	NOUN
fnp-3806	1507	21	:	:	PUNCT
fnp-3806	1507	22	mechanisms	mechanism	NOUN
fnp-3806	1507	23	,	,	PUNCT
fnp-3806	1507	24	genetics	genetic	NOUN
fnp-3806	1507	25	,	,	PUNCT
fnp-3806	1507	26	and	and	CCONJ
fnp-3806	1507	27	lessons	lesson	NOUN
fnp-3806	1507	28	from	from	ADP
fnp-3806	1507	29	other	other	ADJ
fnp-3806	1507	30	pathologies	pathology	NOUN
fnp-3806	1507	31	.	.	PUNCT
fnp-3806	1508	1	front	front	ADJ
fnp-3806	1508	2	neurosci	neurosci	NOUN
fnp-3806	1508	3	2019;13:164	2019;13:164	NOUN
fnp-3806	1508	4	.	.	PUNCT
fnp-3806	1509	1	https://doi.org/10.3389/fnins.2019.00164	https://doi.org/10.3389/fnins.2019.00164	PROPN
fnp-3806	1509	2	baig	baig	PROPN
fnp-3806	1509	3	s	s	PROPN
fnp-3806	1509	4	,	,	PUNCT
fnp-3806	1509	5	palmer	palmer	PROPN
fnp-3806	1509	6	le	le	PROPN
fnp-3806	1509	7	,	,	PUNCT
fnp-3806	1509	8	owen	owen	PROPN
fnp-3806	1509	9	mj	mj	PROPN
fnp-3806	1509	10	,	,	PUNCT
fnp-3806	1509	11	et	et	PROPN
fnp-3806	1509	12	al	al	PROPN
fnp-3806	1509	13	.	.	PROPN
fnp-3806	1509	14	clusterin	clusterin	PROPN
fnp-3806	1509	15	mrna	mrna	PROPN
fnp-3806	1509	16	and	and	CCONJ
fnp-3806	1509	17	protein	protein	NOUN
fnp-3806	1509	18	in	in	ADP
fnp-3806	1509	19	alzheimer	alzheimer	PROPN
fnp-3806	1509	20	's	's	PART
fnp-3806	1509	21	disease	disease	NOUN
fnp-3806	1509	22	.	.	PUNCT
fnp-3806	1510	1	j	j	PROPN
fnp-3806	1510	2	alzheimers	alzheimers	PROPN
fnp-3806	1510	3	dis	dis	PROPN
fnp-3806	1510	4	2012;28:337	2012;28:337	PROPN
fnp-3806	1510	5	-	-	PUNCT
fnp-3806	1510	6	344	344	NUM
fnp-3806	1510	7	.	.	PUNCT
fnp-3806	1510	8	https://doi.org/10.3233/jad-2011-110473	https://doi.org/10.3233/jad-2011-110473	PROPN
fnp-3806	1510	9	miners	miner	NOUN
fnp-3806	1510	10	js	js	PROPN
fnp-3806	1510	11	,	,	PUNCT
fnp-3806	1510	12	clarke	clarke	PROPN
fnp-3806	1510	13	p	p	PROPN
fnp-3806	1510	14	,	,	PUNCT
fnp-3806	1510	15	love	love	PROPN
fnp-3806	1510	16	s.	s.	PROPN
fnp-3806	1510	17	clusterin	clusterin	PROPN
fnp-3806	1510	18	levels	level	NOUN
fnp-3806	1510	19	are	be	AUX
fnp-3806	1510	20	increased	increase	VERB
fnp-3806	1510	21	in	in	ADP
fnp-3806	1510	22	alzheimer	alzheimer	PROPN
fnp-3806	1510	23	's	's	PART
fnp-3806	1510	24	disease	disease	NOUN
fnp-3806	1510	25	and	and	CCONJ
fnp-3806	1510	26	influence	influence	NOUN
fnp-3806	1510	27	the	the	DET
fnp-3806	1510	28	regional	regional	ADJ
fnp-3806	1510	29	distribution	distribution	NOUN
fnp-3806	1510	30	of	of	ADP
fnp-3806	1510	31	aβ	aβ	PROPN
fnp-3806	1510	32	.	.	PUNCT
fnp-3806	1510	33	brain	brain	NOUN
fnp-3806	1510	34	pathol	pathol	NOUN
fnp-3806	1510	35	2017;27:305	2017;27:305	PROPN
fnp-3806	1510	36	-	-	SYM
fnp-3806	1510	37	313	313	NUM
fnp-3806	1510	38	.	.	PUNCT
fnp-3806	1511	1	https://doi.org/10.1111/bpa.12392	https://doi.org/10.1111/bpa.12392	PROPN
fnp-3806	1511	2	kida	kida	PROPN
fnp-3806	1511	3	e	e	PROPN
fnp-3806	1511	4	,	,	PUNCT
fnp-3806	1511	5	choi	choi	NOUN
fnp-3806	1511	6	-	-	PUNCT
fnp-3806	1511	7	miura	miura	PROPN
fnp-3806	1511	8	nh	nh	PROPN
fnp-3806	1511	9	,	,	PUNCT
fnp-3806	1511	10	wisniewski	wisniewski	PROPN
fnp-3806	1511	11	ke	ke	PROPN
fnp-3806	1511	12	.	.	PUNCT
fnp-3806	1512	1	deposition	deposition	NOUN
fnp-3806	1512	2	of	of	ADP
fnp-3806	1512	3	apolipoproteins	apolipoprotein	NOUN
fnp-3806	1512	4	e	e	NOUN
fnp-3806	1512	5	and	and	CCONJ
fnp-3806	1512	6	j	j	PROPN
fnp-3806	1512	7	in	in	ADP
fnp-3806	1512	8	senile	senile	ADJ
fnp-3806	1512	9	plaques	plaque	NOUN
fnp-3806	1512	10	is	be	AUX
fnp-3806	1512	11	topographically	topographically	ADV
fnp-3806	1512	12	determined	determined	ADJ
fnp-3806	1512	13	in	in	ADP
fnp-3806	1512	14	both	both	CCONJ
fnp-3806	1512	15	alzheimer	alzheimer	NOUN
fnp-3806	1512	16	's	's	PART
fnp-3806	1512	17	disease	disease	NOUN
fnp-3806	1512	18	and	and	CCONJ
fnp-3806	1512	19	down	down	NOUN
fnp-3806	1512	20	's	's	PART
fnp-3806	1512	21	syndrome	syndrome	NOUN
fnp-3806	1512	22	brain	brain	NOUN
fnp-3806	1512	23	.	.	PUNCT
fnp-3806	1513	1	brain	brain	NOUN
fnp-3806	1513	2	res	re	NOUN
fnp-3806	1513	3	1995;685:211	1995;685:211	NUM
fnp-3806	1513	4	-	-	NUM
fnp-3806	1513	5	216	216	NUM
fnp-3806	1513	6	.	.	PUNCT
fnp-3806	1514	1	https://doi.org/10.1016/0006-8993(95)00482-6	https://doi.org/10.1016/0006-8993(95)00482-6	PROPN
fnp-3806	1514	2	howlett	howlett	PROPN
fnp-3806	1514	3	dr	dr	PROPN
fnp-3806	1514	4	,	,	PUNCT
fnp-3806	1514	5	hortobágyi	hortobágyi	PROPN
fnp-3806	1514	6	t	t	PROPN
fnp-3806	1514	7	,	,	PUNCT
fnp-3806	1514	8	francis	francis	PROPN
fnp-3806	1514	9	pt	pt	PROPN
fnp-3806	1514	10	.	.	PROPN
fnp-3806	1514	11	clusterin	clusterin	PROPN
fnp-3806	1514	12	associates	associate	NOUN
fnp-3806	1514	13	specifically	specifically	ADV
fnp-3806	1514	14	with	with	ADP
fnp-3806	1514	15	aβ1	aβ1	NOUN
fnp-3806	1514	16	-	-	PUNCT
fnp-3806	1514	17	40	40	NUM
fnp-3806	1514	18	in	in	ADP
fnp-3806	1514	19	alzheimer	alzheimer	PROPN
fnp-3806	1514	20	’s	’s	PART
fnp-3806	1514	21	disease	disease	NOUN
fnp-3806	1514	22	brain	brain	NOUN
fnp-3806	1514	23	tissue	tissue	NOUN
fnp-3806	1514	24	.	.	PUNCT
fnp-3806	1515	1	brain	brain	NOUN
fnp-3806	1515	2	pathol	pathol	NOUN
fnp-3806	1515	3	2013;23:623	2013;23:623	NUM
fnp-3806	1515	4	-	-	SYM
fnp-3806	1515	5	632	632	NUM
fnp-3806	1515	6	.	.	PUNCT
fnp-3806	1516	1	https://doi.org/10.1111/bpa.12057	https://doi.org/10.1111/bpa.12057	PROPN
fnp-3806	1516	2	humphreys	humphreys	PROPN
fnp-3806	1516	3	dt	dt	PROPN
fnp-3806	1516	4	,	,	PUNCT
fnp-3806	1516	5	carver	carver	PROPN
fnp-3806	1516	6	ja	ja	PROPN
fnp-3806	1516	7	,	,	PUNCT
fnp-3806	1516	8	easterbrook	easterbrook	PROPN
fnp-3806	1516	9	-	-	PUNCT
fnp-3806	1516	10	smith	smith	PROPN
fnp-3806	1516	11	sb	sb	PROPN
fnp-3806	1516	12	,	,	PUNCT
fnp-3806	1516	13	et	et	PROPN
fnp-3806	1516	14	al	al	PROPN
fnp-3806	1516	15	.	.	PROPN
fnp-3806	1516	16	clusterin	clusterin	PROPN
fnp-3806	1516	17	has	have	VERB
fnp-3806	1516	18	chaperone	chaperone	VERB
fnp-3806	1516	19	-	-	PUNCT
fnp-3806	1516	20	like	like	ADJ
fnp-3806	1516	21	activity	activity	NOUN
fnp-3806	1516	22	similar	similar	ADJ
fnp-3806	1516	23	to	to	ADP
fnp-3806	1516	24	that	that	PRON
fnp-3806	1516	25	of	of	ADP
fnp-3806	1516	26	small	small	ADJ
fnp-3806	1516	27	heat	heat	NOUN
fnp-3806	1516	28	shock	shock	NOUN
fnp-3806	1516	29	proteins	protein	NOUN
fnp-3806	1516	30	.	.	PUNCT
fnp-3806	1517	1	j	j	PROPN
fnp-3806	1517	2	biol	biol	PROPN
fnp-3806	1517	3	chem	chem	NOUN
fnp-3806	1517	4	1999	1999	NUM
fnp-3806	1517	5	;	;	PUNCT
fnp-3806	1517	6	274	274	NUM
fnp-3806	1517	7	:	:	SYM
fnp-3806	1517	8	6875	6875	NUM
fnp-3806	1517	9	-	-	SYM
fnp-3806	1517	10	6881	6881	NUM
fnp-3806	1517	11	.	.	PUNCT
fnp-3806	1518	1	https://doi.org/10.1074/jbc.274.11.6875	https://doi.org/10.1074/jbc.274.11.6875	PROPN
fnp-3806	1518	2	oh	oh	NUM
fnp-3806	1518	3	sb	sb	PROPN
fnp-3806	1518	4	,	,	PUNCT
fnp-3806	1518	5	kim	kim	PROPN
fnp-3806	1518	6	ms	ms	PROPN
fnp-3806	1518	7	,	,	PUNCT
fnp-3806	1518	8	park	park	NOUN
fnp-3806	1518	9	s	s	PROPN
fnp-3806	1518	10	,	,	PUNCT
fnp-3806	1518	11	et	et	PROPN
fnp-3806	1518	12	al	al	PROPN
fnp-3806	1518	13	.	.	PROPN
fnp-3806	1518	14	clusterin	clusterin	PROPN
fnp-3806	1518	15	contributes	contribute	VERB
fnp-3806	1518	16	to	to	ADP
fnp-3806	1518	17	early	early	ADJ
fnp-3806	1518	18	stage	stage	NOUN
fnp-3806	1518	19	of	of	ADP
fnp-3806	1518	20	alzheimer	alzheimer	PROPN
fnp-3806	1518	21	's	's	PART
fnp-3806	1518	22	disease	disease	NOUN
fnp-3806	1518	23	pathogenesis	pathogenesis	NOUN
fnp-3806	1518	24	.	.	PUNCT
fnp-3806	1519	1	brain	brain	NOUN
fnp-3806	1519	2	pathol	pathol	NOUN
fnp-3806	1519	3	2019;29:217	2019;29:217	NUM
fnp-3806	1519	4	-	-	SYM
fnp-3806	1519	5	231	231	NUM
fnp-3806	1519	6	.	.	PUNCT
fnp-3806	1520	1	https://doi.org/10.1111/bpa.12660	https://doi.org/10.1111/bpa.12660	PROPN
fnp-3806	1520	2	bell	bell	PROPN
fnp-3806	1520	3	rd	rd	PROPN
fnp-3806	1520	4	,	,	PUNCT
fnp-3806	1520	5	sagare	sagare	PROPN
fnp-3806	1520	6	ap	ap	PROPN
fnp-3806	1520	7	,	,	PUNCT
fnp-3806	1520	8	friedman	friedman	PROPN
fnp-3806	1520	9	ae	ae	PROPN
fnp-3806	1520	10	,	,	PUNCT
fnp-3806	1520	11	et	et	PROPN
fnp-3806	1520	12	al	al	PROPN
fnp-3806	1520	13	.	.	PUNCT
fnp-3806	1520	14	transport	transport	NOUN
fnp-3806	1520	15	pathways	pathway	NOUN
fnp-3806	1520	16	for	for	ADP
fnp-3806	1520	17	clearance	clearance	NOUN
fnp-3806	1520	18	of	of	ADP
fnp-3806	1520	19	human	human	PROPN
fnp-3806	1520	20	alzheimer	alzheimer	PROPN
fnp-3806	1520	21	’s	’s	PART
fnp-3806	1520	22	amyloid	amyloid	NOUN
fnp-3806	1520	23	β	β	NOUN
fnp-3806	1520	24	-	-	NOUN
fnp-3806	1520	25	peptide	peptide	NOUN
fnp-3806	1520	26	and	and	CCONJ
fnp-3806	1520	27	apolipoproteins	apolipoprotein	NOUN
fnp-3806	1520	28	e	e	PROPN
fnp-3806	1520	29	and	and	CCONJ
fnp-3806	1520	30	j	j	PROPN
fnp-3806	1520	31	in	in	ADP
fnp-3806	1520	32	the	the	DET
fnp-3806	1520	33	mouse	mouse	NOUN
fnp-3806	1520	34	central	central	ADJ
fnp-3806	1520	35	nervous	nervous	ADJ
fnp-3806	1520	36	system	system	NOUN
fnp-3806	1520	37	.	.	PUNCT
fnp-3806	1521	1	j	j	PROPN
fnp-3806	1521	2	cereb	cereb	PROPN
fnp-3806	1521	3	blood	blood	PROPN
fnp-3806	1521	4	flow	flow	NOUN
fnp-3806	1521	5	metab	metab	ADJ
fnp-3806	1521	6	2007;27	2007;27	NOUN
fnp-3806	1521	7	:	:	PUNCT
fnp-3806	1521	8	909	909	NUM
fnp-3806	1521	9	-	-	SYM
fnp-3806	1521	10	918	918	NUM
fnp-3806	1521	11	.	.	PUNCT
fnp-3806	1522	1	https://doi.org/10.1038/sj.jcbfm.9600419	https://doi.org/10.1038/sj.jcbfm.9600419	X
fnp-3806	1522	2	tarasoff	tarasoff	PROPN
fnp-3806	1522	3	-	-	PUNCT
fnp-3806	1522	4	conway	conway	PROPN
fnp-3806	1522	5	jm	jm	PROPN
fnp-3806	1522	6	,	,	PUNCT
fnp-3806	1522	7	carare	carare	PROPN
fnp-3806	1522	8	ro	ro	PROPN
fnp-3806	1522	9	,	,	PUNCT
fnp-3806	1522	10	osorio	osorio	NOUN
fnp-3806	1522	11	rs	rs	PROPN
fnp-3806	1522	12	,	,	PUNCT
fnp-3806	1522	13	et	et	PROPN
fnp-3806	1522	14	al	al	PROPN
fnp-3806	1522	15	.	.	PUNCT
fnp-3806	1522	16	clearance	clearance	NOUN
fnp-3806	1522	17	systems	system	NOUN
fnp-3806	1522	18	in	in	ADP
fnp-3806	1522	19	the	the	DET
fnp-3806	1522	20	brain	brain	NOUN
fnp-3806	1522	21	—	—	PUNCT
fnp-3806	1522	22	implications	implication	NOUN
fnp-3806	1522	23	for	for	ADP
fnp-3806	1522	24	alzheimer	alzheimer	NOUN
fnp-3806	1522	25	disease	disease	NOUN
fnp-3806	1522	26	.	.	PUNCT
fnp-3806	1523	1	nat	nat	PROPN
fnp-3806	1523	2	rev	rev	VERB
fnp-3806	1523	3	neurol	neurol	PROPN
fnp-3806	1523	4	2015;11:457	2015;11:457	PROPN
fnp-3806	1523	5	-	-	PUNCT
fnp-3806	1523	6	470	470	NUM
fnp-3806	1523	7	.	.	PUNCT
fnp-3806	1524	1	https://doi.org/10.1038/nrneurol.2015.119	https://doi.org/10.1038/nrneurol.2015.119	PROPN
fnp-3806	1524	2	calero	calero	PROPN
fnp-3806	1524	3	m	m	PROPN
fnp-3806	1524	4	,	,	PUNCT
fnp-3806	1524	5	rostagno	rostagno	NOUN
fnp-3806	1524	6	a	a	NOUN
fnp-3806	1524	7	,	,	PUNCT
fnp-3806	1524	8	matsubara	matsubara	NOUN
fnp-3806	1524	9	e	e	NOUN
fnp-3806	1524	10	,	,	PUNCT
fnp-3806	1524	11	et	et	PROPN
fnp-3806	1524	12	al	al	PROPN
fnp-3806	1524	13	.	.	PROPN
fnp-3806	1525	1	apolipoprotein	apolipoprotein	PROPN
fnp-3806	1525	2	j	j	PROPN
fnp-3806	1525	3	(	(	PUNCT
fnp-3806	1525	4	clusterin	clusterin	NOUN
fnp-3806	1525	5	)	)	PUNCT
fnp-3806	1525	6	and	and	CCONJ
fnp-3806	1525	7	alzheimer	alzheimer	PROPN
fnp-3806	1525	8	's	's	PART
fnp-3806	1525	9	disease	disease	NOUN
fnp-3806	1525	10	.	.	PUNCT
fnp-3806	1526	1	microsc	microsc	PROPN
fnp-3806	1526	2	res	re	NOUN
fnp-3806	1526	3	tech	tech	NOUN
fnp-3806	1526	4	2000;50:305	2000;50:305	PROPN
fnp-3806	1526	5	-	-	SYM
fnp-3806	1526	6	315	315	NUM
fnp-3806	1526	7	.	.	PUNCT
fnp-3806	1527	1	https://doi.org/10.1002/1097-0029(20000815)50:4<305::aid-jemt10>3.0.co;2-l	https://doi.org/10.1002/1097-0029(20000815)50:4<305::aid-jemt10>3.0.co;2-l	NUM
fnp-3806	1527	2	matsubara	matsubara	NOUN
fnp-3806	1527	3	e	e	NOUN
fnp-3806	1527	4	,	,	PUNCT
fnp-3806	1527	5	soto	soto	PROPN
fnp-3806	1527	6	c	c	PROPN
fnp-3806	1527	7	,	,	PUNCT
fnp-3806	1527	8	governale	governale	PROPN
fnp-3806	1527	9	s	s	PART
fnp-3806	1527	10	,	,	PUNCT
fnp-3806	1527	11	frangione	frangione	NOUN
fnp-3806	1527	12	b	b	PROPN
fnp-3806	1527	13	,	,	PUNCT
fnp-3806	1527	14	ghiso	ghiso	PROPN
fnp-3806	1527	15	j.	j.	PROPN
fnp-3806	1527	16	apolipoprotein	apolipoprotein	PROPN
fnp-3806	1527	17	j	j	PROPN
fnp-3806	1527	18	and	and	CCONJ
fnp-3806	1527	19	alzheimer	alzheimer	PROPN
fnp-3806	1527	20	’s	’s	PART
fnp-3806	1527	21	amyloid	amyloid	NOUN
fnp-3806	1527	22	beta	beta	PROPN
fnp-3806	1527	23	solubility	solubility	PROPN
fnp-3806	1527	24	.	.	PUNCT
fnp-3806	1528	1	biochem	biochem	PROPN
fnp-3806	1528	2	j	j	PROPN
fnp-3806	1528	3	1996;316:671	1996;316:671	NUM
fnp-3806	1528	4	-	-	SYM
fnp-3806	1528	5	679	679	NUM
fnp-3806	1528	6	.	.	PUNCT
fnp-3806	1529	1	https://doi.org/10.1042/bj3160671	https://doi.org/10.1042/bj3160671	PROPN
fnp-3806	1529	2	robbins	robbins	PROPN
fnp-3806	1529	3	jp	jp	PROPN
fnp-3806	1529	4	,	,	PUNCT
fnp-3806	1529	5	perfect	perfect	ADJ
fnp-3806	1529	6	l	l	NOUN
fnp-3806	1529	7	,	,	PUNCT
fnp-3806	1529	8	ribe	ribe	VERB
fnp-3806	1529	9	em	em	PRON
fnp-3806	1529	10	,	,	PUNCT
fnp-3806	1529	11	et	et	PROPN
fnp-3806	1529	12	al	al	PROPN
fnp-3806	1529	13	.	.	PROPN
fnp-3806	1529	14	clusterin	clusterin	PROPN
fnp-3806	1529	15	is	be	AUX
fnp-3806	1529	16	required	require	VERB
fnp-3806	1529	17	for	for	ADP
fnp-3806	1529	18	β	β	NOUN
fnp-3806	1529	19	-	-	NOUN
fnp-3806	1529	20	amyloid	amyloid	NOUN
fnp-3806	1529	21	toxicity	toxicity	NOUN
fnp-3806	1529	22	in	in	ADP
fnp-3806	1529	23	human	human	ADJ
fnp-3806	1529	24	ipsc	ipsc	NOUN
fnp-3806	1529	25	-	-	PUNCT
fnp-3806	1529	26	derived	derive	VERB
fnp-3806	1529	27	neurons	neuron	NOUN
fnp-3806	1529	28	.	.	PUNCT
fnp-3806	1530	1	front	front	ADJ
fnp-3806	1530	2	neurosci	neurosci	NOUN
fnp-3806	1530	3	2018;12:504	2018;12:504	NOUN
fnp-3806	1530	4	.	.	PUNCT
fnp-3806	1531	1	https://doi.org/10.3389/fnins.2018.00504	https://doi.org/10.3389/fnins.2018.00504	PROPN
fnp-3806	1531	2	zhou	zhou	PROPN
fnp-3806	1531	3	y	y	PROPN
fnp-3806	1531	4	,	,	PUNCT
fnp-3806	1531	5	hayashi	hayashi	PROPN
fnp-3806	1531	6	i	i	PROPN
fnp-3806	1531	7	,	,	PUNCT
fnp-3806	1531	8	wong	wong	PROPN
fnp-3806	1531	9	j	j	PROPN
fnp-3806	1531	10	,	,	PUNCT
fnp-3806	1531	11	et	et	PROPN
fnp-3806	1531	12	al	al	PROPN
fnp-3806	1531	13	.	.	PROPN
fnp-3806	1531	14	intracellular	intracellular	ADJ
fnp-3806	1531	15	clusterin	clusterin	NOUN
fnp-3806	1531	16	interacts	interact	VERB
fnp-3806	1531	17	with	with	ADP
fnp-3806	1531	18	brain	brain	NOUN
fnp-3806	1531	19	isoforms	isoform	NOUN
fnp-3806	1531	20	of	of	ADP
fnp-3806	1531	21	the	the	DET
fnp-3806	1531	22	bridging	bridge	VERB
fnp-3806	1531	23	integrator	integrator	NOUN
fnp-3806	1531	24	1	1	NUM
fnp-3806	1531	25	and	and	CCONJ
fnp-3806	1531	26	with	with	ADP
fnp-3806	1531	27	the	the	DET
fnp-3806	1531	28	microtubule	microtubule	NOUN
fnp-3806	1531	29	-	-	PUNCT
fnp-3806	1531	30	associated	associate	VERB
fnp-3806	1531	31	protein	protein	NOUN
fnp-3806	1531	32	tau	tau	PROPN
fnp-3806	1531	33	in	in	ADP
fnp-3806	1531	34	alzheimer	alzheimer	PROPN
fnp-3806	1531	35	's	's	PART
fnp-3806	1531	36	disease	disease	NOUN
fnp-3806	1531	37	.	.	PUNCT
fnp-3806	1532	1	plos	plos	PROPN
fnp-3806	1532	2	one	one	NUM
fnp-3806	1532	3	2014;9	2014;9	NUM
fnp-3806	1532	4	:	:	PUNCT
fnp-3806	1532	5	e103187	e103187	PROPN
fnp-3806	1532	6	.	.	PROPN
fnp-3806	1532	7	https://doi.org/10.1371/journal.pone.0103187	https://doi.org/10.1371/journal.pone.0103187	PROPN
fnp-3806	1532	8	rijal	rijal	PROPN
fnp-3806	1532	9	upadhaya	upadhaya	NOUN
fnp-3806	1532	10	a	a	NOUN
fnp-3806	1532	11	,	,	PUNCT
fnp-3806	1532	12	kosterin	kosterin	NOUN
fnp-3806	1532	13	i	i	PROPN
fnp-3806	1532	14	,	,	PUNCT
fnp-3806	1532	15	kumar	kumar	PROPN
fnp-3806	1532	16	s	s	PROPN
fnp-3806	1532	17	,	,	PUNCT
fnp-3806	1532	18	et	et	PROPN
fnp-3806	1532	19	al	al	PROPN
fnp-3806	1532	20	.	.	PUNCT
fnp-3806	1533	1	biochemical	biochemical	ADJ
fnp-3806	1533	2	stages	stage	NOUN
fnp-3806	1533	3	of	of	ADP
fnp-3806	1533	4	amyloid	amyloid	NOUN
fnp-3806	1533	5	-	-	PUNCT
fnp-3806	1533	6	β	β	X
fnp-3806	1533	7	peptide	peptide	NOUN
fnp-3806	1533	8	aggregation	aggregation	NOUN
fnp-3806	1533	9	and	and	CCONJ
fnp-3806	1533	10	accumulation	accumulation	NOUN
fnp-3806	1533	11	in	in	ADP
fnp-3806	1533	12	the	the	DET
fnp-3806	1533	13	human	human	ADJ
fnp-3806	1533	14	brain	brain	NOUN
fnp-3806	1533	15	and	and	CCONJ
fnp-3806	1533	16	their	their	PRON
fnp-3806	1533	17	association	association	NOUN
fnp-3806	1533	18	with	with	ADP
fnp-3806	1533	19	symptomatic	symptomatic	ADJ
fnp-3806	1533	20	and	and	CCONJ
fnp-3806	1533	21	pathologically	pathologically	ADV
fnp-3806	1533	22	preclinical	preclinical	ADJ
fnp-3806	1533	23	alzheimer	alzheimer	NOUN
fnp-3806	1533	24	's	's	PART
fnp-3806	1533	25	disease	disease	NOUN
fnp-3806	1533	26	.	.	PUNCT
fnp-3806	1534	1	brain	brain	NOUN
fnp-3806	1534	2	2014;137:887	2014;137:887	NUM
fnp-3806	1534	3	-	-	SYM
fnp-3806	1534	4	903	903	NUM
fnp-3806	1534	5	.	.	PUNCT
fnp-3806	1535	1	https://doi.org/10.1093/brain/awt362	https://doi.org/10.1093/brain/awt362	PROPN
fnp-3806	1535	2	thal	thal	PROPN
fnp-3806	1535	3	dr	dr	PROPN
fnp-3806	1535	4	,	,	PUNCT
fnp-3806	1535	5	walter	walter	PROPN
fnp-3806	1535	6	j	j	PROPN
fnp-3806	1535	7	,	,	PUNCT
fnp-3806	1535	8	saido	saido	PROPN
fnp-3806	1535	9	tc	tc	SYM
fnp-3806	1535	10	,	,	PUNCT
fnp-3806	1535	11	fändrich	fändrich	PROPN
fnp-3806	1535	12	m.	m.	NOUN
fnp-3806	1535	13	neuropathology	neuropathology	NOUN
fnp-3806	1535	14	and	and	CCONJ
fnp-3806	1535	15	biochemistry	biochemistry	NOUN
fnp-3806	1535	16	of	of	ADP
fnp-3806	1535	17	abeta	abeta	PROPN
fnp-3806	1535	18	and	and	CCONJ
fnp-3806	1535	19	its	its	PRON
fnp-3806	1535	20	aggregates	aggregate	NOUN
fnp-3806	1535	21	in	in	ADP
fnp-3806	1535	22	alzheimer	alzheimer	PROPN
fnp-3806	1535	23	's	's	PART
fnp-3806	1535	24	disease	disease	NOUN
fnp-3806	1535	25	.	.	PUNCT
fnp-3806	1536	1	acta	acta	PROPN
fnp-3806	1536	2	neuropathol	neuropathol	PROPN
fnp-3806	1536	3	2015;129:167	2015;129:167	NUM
fnp-3806	1536	4	-	-	SYM
fnp-3806	1536	5	182	182	NUM
fnp-3806	1536	6	.	.	PUNCT
fnp-3806	1537	1	https://doi.org/10.1007/s00401-014-1375-y	https://doi.org/10.1007/s00401-014-1375-y	PROPN
fnp-3806	1537	2	lambert	lambert	PROPN
fnp-3806	1537	3	mp	mp	PROPN
fnp-3806	1537	4	,	,	PUNCT
fnp-3806	1537	5	barlow	barlow	PROPN
fnp-3806	1537	6	ak	ak	PROPN
fnp-3806	1537	7	,	,	PUNCT
fnp-3806	1537	8	chromy	chromy	PROPN
fnp-3806	1537	9	ba	ba	PROPN
fnp-3806	1537	10	,	,	PUNCT
fnp-3806	1537	11	et	et	PROPN
fnp-3806	1537	12	al	al	PROPN
fnp-3806	1537	13	.	.	PROPN
fnp-3806	1538	1	diffusible	diffusible	ADJ
fnp-3806	1538	2	,	,	PUNCT
fnp-3806	1538	3	nonfibrillar	nonfibrillar	ADJ
fnp-3806	1538	4	ligands	ligand	NOUN
fnp-3806	1538	5	derived	derive	VERB
fnp-3806	1538	6	from	from	ADP
fnp-3806	1538	7	abeta1	abeta1	PROPN
fnp-3806	1538	8	-	-	PUNCT
fnp-3806	1538	9	42	42	NUM
fnp-3806	1538	10	are	be	AUX
fnp-3806	1538	11	potent	potent	ADJ
fnp-3806	1538	12	central	central	ADJ
fnp-3806	1538	13	nervous	nervous	ADJ
fnp-3806	1538	14	system	system	NOUN
fnp-3806	1538	15	neurotoxins	neurotoxin	NOUN
fnp-3806	1538	16	.	.	PUNCT
fnp-3806	1539	1	proc	proc	PROPN
fnp-3806	1539	2	natl	natl	PROPN
fnp-3806	1539	3	acad	acad	PROPN
fnp-3806	1539	4	sci	sci	PROPN
fnp-3806	1539	5	usa	usa	PROPN
fnp-3806	1539	6	1998;95:6448	1998;95:6448	PROPN
fnp-3806	1539	7	-	-	SYM
fnp-3806	1539	8	53	53	NUM
fnp-3806	1539	9	.	.	PUNCT
fnp-3806	1540	1	https://doi.org/10.1073/pnas.95.11.6448	https://doi.org/10.1073/pnas.95.11.6448	PROPN
fnp-3806	1540	2	gong	gong	PROPN
fnp-3806	1540	3	y	y	PROPN
fnp-3806	1540	4	,	,	PUNCT
fnp-3806	1540	5	chang	chang	PROPN
fnp-3806	1540	6	l	l	PROPN
fnp-3806	1540	7	,	,	PUNCT
fnp-3806	1540	8	viola	viola	PROPN
fnp-3806	1540	9	kl	kl	PROPN
fnp-3806	1540	10	,	,	PUNCT
fnp-3806	1540	11	et	et	PROPN
fnp-3806	1540	12	al	al	PROPN
fnp-3806	1540	13	.	.	PROPN
fnp-3806	1540	14	alzheimer	alzheimer	PROPN
fnp-3806	1540	15	’s	’s	PART
fnp-3806	1540	16	disease	disease	NOUN
fnp-3806	1540	17	-	-	PUNCT
fnp-3806	1540	18	affected	affect	VERB
fnp-3806	1540	19	brain	brain	NOUN
fnp-3806	1540	20	:	:	PUNCT
fnp-3806	1540	21	presence	presence	NOUN
fnp-3806	1540	22	of	of	ADP
fnp-3806	1540	23	oligomeric	oligomeric	NOUN
fnp-3806	1540	24	a	a	DET
fnp-3806	1540	25	beta	beta	NOUN
fnp-3806	1540	26	ligands	ligand	NOUN
fnp-3806	1540	27	(	(	PUNCT
fnp-3806	1540	28	addls	addls	NOUN
fnp-3806	1540	29	)	)	PUNCT
fnp-3806	1540	30	suggests	suggest	VERB
fnp-3806	1540	31	a	a	DET
fnp-3806	1540	32	molecular	molecular	ADJ
fnp-3806	1540	33	basis	basis	NOUN
fnp-3806	1540	34	for	for	ADP
fnp-3806	1540	35	reversible	reversible	ADJ
fnp-3806	1540	36	memory	memory	NOUN
fnp-3806	1540	37	loss	loss	NOUN
fnp-3806	1540	38	.	.	PUNCT
fnp-3806	1541	1	proc	proc	PROPN
fnp-3806	1541	2	natl	natl	PROPN
fnp-3806	1541	3	acad	acad	PROPN
fnp-3806	1541	4	sci	sci	PROPN
fnp-3806	1541	5	usa	usa	PROPN
fnp-3806	1541	6	2003;100:10417	2003;100:10417	NUM
fnp-3806	1541	7	-	-	SYM
fnp-3806	1541	8	10422	10422	NUM
fnp-3806	1541	9	.	.	PUNCT
fnp-3806	1542	1	https://doi.org/10.1073/pnas.1834302100	https://doi.org/10.1073/pnas.1834302100	PROPN
fnp-3806	1542	2	hayden	hayden	PROPN
fnp-3806	1542	3	ey	ey	NOUN
fnp-3806	1542	4	,	,	PUNCT
fnp-3806	1542	5	teplow	teplow	PROPN
fnp-3806	1542	6	db	db	PROPN
fnp-3806	1542	7	.	.	PUNCT
fnp-3806	1542	8	amyloid	amyloid	NOUN
fnp-3806	1542	9	beta	beta	NOUN
fnp-3806	1542	10	-	-	PUNCT
fnp-3806	1542	11	protein	protein	NOUN
fnp-3806	1542	12	oligomers	oligomer	NOUN
fnp-3806	1542	13	and	and	CCONJ
fnp-3806	1542	14	alzheimer	alzheimer	PROPN
fnp-3806	1542	15	’s	’s	PART
fnp-3806	1542	16	disease	disease	NOUN
fnp-3806	1542	17	,	,	PUNCT
fnp-3806	1542	18	alzheimers	alzheimers	PROPN
fnp-3806	1542	19	res	re	NOUN
fnp-3806	1542	20	ther	ther	ADV
fnp-3806	1542	21	2013	2013	NUM
fnp-3806	1542	22	;	;	PUNCT
fnp-3806	1542	23	5	5	NUM
fnp-3806	1542	24	:	:	SYM
fnp-3806	1542	25	60	60	NUM
fnp-3806	1542	26	.	.	X
fnp-3806	1543	1	https://doi.org/10.1186/alzrt226	https://doi.org/10.1186/alzrt226	VERB
fnp-3806	1543	2	viola	viola	PROPN
fnp-3806	1543	3	kl	kl	PROPN
fnp-3806	1543	4	,	,	PUNCT
fnp-3806	1543	5	klein	klein	PROPN
fnp-3806	1543	6	wl	wl	PROPN
fnp-3806	1543	7	.	.	PUNCT
fnp-3806	1544	1	amyloid	amyloid	PROPN
fnp-3806	1544	2	β	β	X
fnp-3806	1544	3	oligomers	oligomer	NOUN
fnp-3806	1544	4	in	in	ADP
fnp-3806	1544	5	alzheimer	alzheimer	PROPN
fnp-3806	1544	6	's	's	PART
fnp-3806	1544	7	disease	disease	NOUN
fnp-3806	1544	8	pathogenesis	pathogenesis	NOUN
fnp-3806	1544	9	,	,	PUNCT
fnp-3806	1544	10	treatment	treatment	NOUN
fnp-3806	1544	11	,	,	PUNCT
fnp-3806	1544	12	and	and	CCONJ
fnp-3806	1544	13	diagnosis	diagnosis	NOUN
fnp-3806	1544	14	.	.	PUNCT
fnp-3806	1545	1	acta	acta	PROPN
fnp-3806	1545	2	neuropathol	neuropathol	PROPN
fnp-3806	1545	3	2015;129:183	2015;129:183	NUM
fnp-3806	1545	4	-	-	SYM
fnp-3806	1545	5	206	206	NUM
fnp-3806	1545	6	.	.	PUNCT
fnp-3806	1546	1	https://doi.org/10.1007/s00401-015-1386-3	https://doi.org/10.1007/s00401-015-1386-3	PROPN
fnp-3806	1546	2	mroczko	mroczko	PROPN
fnp-3806	1546	3	b	b	PROPN
fnp-3806	1546	4	,	,	PUNCT
fnp-3806	1546	5	groblewska	groblewska	PROPN
fnp-3806	1546	6	m	m	PROPN
fnp-3806	1546	7	,	,	PUNCT
fnp-3806	1546	8	litman	litman	NOUN
fnp-3806	1546	9	-	-	PUNCT
fnp-3806	1546	10	zawadzka	zawadzka	PROPN
fnp-3806	1546	11	a	a	PROPN
fnp-3806	1546	12	,	,	PUNCT
fnp-3806	1546	13	et	et	PROPN
fnp-3806	1546	14	al	al	PROPN
fnp-3806	1546	15	.	.	PUNCT
fnp-3806	1546	16	cellular	cellular	ADJ
fnp-3806	1546	17	receptors	receptor	NOUN
fnp-3806	1546	18	of	of	ADP
fnp-3806	1546	19	amyloid	amyloid	NOUN
fnp-3806	1546	20	β	β	X
fnp-3806	1546	21	oligomers	oligomer	NOUN
fnp-3806	1546	22	(	(	PUNCT
fnp-3806	1546	23	aβos	aβos	PROPN
fnp-3806	1546	24	)	)	PUNCT
fnp-3806	1546	25	in	in	ADP
fnp-3806	1546	26	alzheimer	alzheimer	PROPN
fnp-3806	1546	27	's	's	PART
fnp-3806	1546	28	disease	disease	NOUN
fnp-3806	1546	29	.	.	PUNCT
fnp-3806	1547	1	int	int	PROPN
fnp-3806	1547	2	j	j	PROPN
fnp-3806	1547	3	mol	mol	ADP
fnp-3806	1547	4	sci	sci	PROPN
fnp-3806	1547	5	2018;19:1884	2018;19:1884	PROPN
fnp-3806	1547	6	.	.	PUNCT
fnp-3806	1548	1	https://doi.org/10.3390/ijms19071884	https://doi.org/10.3390/ijms19071884	PROPN
fnp-3806	1548	2	mroczko	mroczko	PROPN
fnp-3806	1548	3	b	b	PROPN
fnp-3806	1548	4	,	,	PUNCT
fnp-3806	1548	5	groblewska	groblewska	PROPN
fnp-3806	1548	6	m	m	PROPN
fnp-3806	1548	7	,	,	PUNCT
fnp-3806	1548	8	litman	litman	NOUN
fnp-3806	1548	9	-	-	PUNCT
fnp-3806	1548	10	zawadzka	zawadzka	PROPN
fnp-3806	1548	11	a	a	PROPN
fnp-3806	1548	12	,	,	PUNCT
fnp-3806	1548	13	et	et	PROPN
fnp-3806	1548	14	al	al	PROPN
fnp-3806	1548	15	.	.	PUNCT
fnp-3806	1549	1	amyloid	amyloid	PROPN
fnp-3806	1549	2	β	β	X
fnp-3806	1549	3	oligomers	oligomer	NOUN
fnp-3806	1549	4	(	(	PUNCT
fnp-3806	1549	5	aβos	aβos	PROPN
fnp-3806	1549	6	)	)	PUNCT
fnp-3806	1549	7	in	in	ADP
fnp-3806	1549	8	alzheimer	alzheimer	PROPN
fnp-3806	1549	9	's	's	PART
fnp-3806	1549	10	disease	disease	NOUN
fnp-3806	1549	11	.	.	PUNCT
fnp-3806	1550	1	j	j	PROPN
fnp-3806	1550	2	neural	neural	PROPN
fnp-3806	1550	3	transm	transm	PROPN
fnp-3806	1550	4	2018;125:177	2018;125:177	NUM
fnp-3806	1550	5	-	-	SYM
fnp-3806	1550	6	191	191	NUM
fnp-3806	1550	7	.	.	PUNCT
fnp-3806	1551	1	https://doi.org/10.1007/s00702-017-1820-x	https://doi.org/10.1007/s00702-017-1820-x	PROPN
fnp-3806	1551	2	kayed	kayed	PROPN
fnp-3806	1551	3	r	r	PROPN
fnp-3806	1551	4	,	,	PUNCT
fnp-3806	1551	5	head	head	NOUN
fnp-3806	1551	6	e	e	NOUN
fnp-3806	1551	7	,	,	PUNCT
fnp-3806	1551	8	thompson	thompson	PROPN
fnp-3806	1551	9	jl	jl	PROPN
fnp-3806	1551	10	,	,	PUNCT
fnp-3806	1551	11	et	et	PROPN
fnp-3806	1551	12	al	al	PROPN
fnp-3806	1551	13	.	.	PUNCT
fnp-3806	1552	1	common	common	ADJ
fnp-3806	1552	2	structure	structure	NOUN
fnp-3806	1552	3	of	of	ADP
fnp-3806	1552	4	soluble	soluble	ADJ
fnp-3806	1552	5	amyloid	amyloid	NOUN
fnp-3806	1552	6	oligomers	oligomer	NOUN
fnp-3806	1552	7	implies	imply	VERB
fnp-3806	1552	8	common	common	ADJ
fnp-3806	1552	9	mechanism	mechanism	NOUN
fnp-3806	1552	10	of	of	ADP
fnp-3806	1552	11	pathogenesis	pathogenesis	NOUN
fnp-3806	1552	12	.	.	PUNCT
fnp-3806	1553	1	science	science	NOUN
fnp-3806	1553	2	2003;300:486	2003;300:486	NUM
fnp-3806	1553	3	-	-	SYM
fnp-3806	1553	4	489	489	NUM
fnp-3806	1553	5	.	.	PUNCT
fnp-3806	1554	1	https://doi.org/10.1126/science.1079469	https://doi.org/10.1126/science.1079469	PROPN
fnp-3806	1554	2	deshpande	deshpande	VERB
fnp-3806	1554	3	a	a	PRON
fnp-3806	1554	4	,	,	PUNCT
fnp-3806	1554	5	mina	mina	PROPN
fnp-3806	1554	6	e	e	NOUN
fnp-3806	1554	7	,	,	PUNCT
fnp-3806	1554	8	glabe	glabe	PROPN
fnp-3806	1554	9	c	c	NOUN
fnp-3806	1554	10	,	,	PUNCT
fnp-3806	1554	11	et	et	PROPN
fnp-3806	1554	12	al	al	PROPN
fnp-3806	1554	13	.	.	PUNCT
fnp-3806	1555	1	different	different	ADJ
fnp-3806	1555	2	conformations	conformation	NOUN
fnp-3806	1555	3	of	of	ADP
fnp-3806	1555	4	amyloid	amyloid	NOUN
fnp-3806	1555	5	beta	beta	NOUN
fnp-3806	1555	6	induce	induce	VERB
fnp-3806	1555	7	neurotoxicity	neurotoxicity	NOUN
fnp-3806	1555	8	by	by	ADP
fnp-3806	1555	9	distinct	distinct	ADJ
fnp-3806	1555	10	mechanisms	mechanism	NOUN
fnp-3806	1555	11	in	in	ADP
fnp-3806	1555	12	human	human	ADJ
fnp-3806	1555	13	cortical	cortical	ADJ
fnp-3806	1555	14	neurons	neuron	NOUN
fnp-3806	1555	15	.	.	PUNCT
fnp-3806	1556	1	j	j	PROPN
fnp-3806	1556	2	neurosci	neurosci	PROPN
fnp-3806	1556	3	2006;26:6011	2006;26:6011	PROPN
fnp-3806	1556	4	-	-	SYM
fnp-3806	1556	5	6018	6018	NUM
fnp-3806	1556	6	.	.	PUNCT
fnp-3806	1557	1	https://doi.org/10.1523/jneurosci.1189-06.2006	https://doi.org/10.1523/jneurosci.1189-06.2006	ADJ
fnp-3806	1557	2	glabe	glabe	PROPN
fnp-3806	1557	3	cg	cg	NOUN
fnp-3806	1557	4	.	.	PUNCT
fnp-3806	1558	1	common	common	ADJ
fnp-3806	1558	2	mechanisms	mechanism	NOUN
fnp-3806	1558	3	of	of	ADP
fnp-3806	1558	4	amyloid	amyloid	NOUN
fnp-3806	1558	5	oligomer	oligomer	ADJ
fnp-3806	1558	6	pathogenesis	pathogenesis	NOUN
fnp-3806	1558	7	in	in	ADP
fnp-3806	1558	8	degenerative	degenerative	ADJ
fnp-3806	1558	9	disease	disease	NOUN
fnp-3806	1558	10	.	.	PUNCT
fnp-3806	1559	1	neurobiol	neurobiol	ADJ
fnp-3806	1559	2	aging	age	VERB
fnp-3806	1559	3	2006;27:570	2006;27:570	NUM
fnp-3806	1559	4	-	-	SYM
fnp-3806	1559	5	575	575	NUM
fnp-3806	1559	6	.	.	PUNCT
fnp-3806	1560	1	https://doi.org/10.1016/j.neurobiolaging.2005.04.017	https://doi.org/10.1016/j.neurobiolaging.2005.04.017	NUM
fnp-3806	1560	2	walsh	walsh	PROPN
fnp-3806	1560	3	dm	dm	PROPN
fnp-3806	1560	4	,	,	PUNCT
fnp-3806	1560	5	selkoe	selkoe	ADJ
fnp-3806	1560	6	dj	dj	NOUN
fnp-3806	1560	7	.	.	PUNCT
fnp-3806	1561	1	a	a	DET
fnp-3806	1561	2	beta	beta	ADJ
fnp-3806	1561	3	oligomers	oligomer	NOUN
fnp-3806	1561	4	a	a	DET
fnp-3806	1561	5	decade	decade	NOUN
fnp-3806	1561	6	of	of	ADP
fnp-3806	1561	7	discovery	discovery	NOUN
fnp-3806	1561	8	.	.	PUNCT
fnp-3806	1562	1	j	j	PROPN
fnp-3806	1562	2	neurochem	neurochem	PROPN
fnp-3806	1562	3	2007;101:1172	2007;101:1172	PROPN
fnp-3806	1562	4	-	-	PUNCT
fnp-3806	1562	5	1184	1184	NUM
fnp-3806	1562	6	.	.	PUNCT
fnp-3806	1563	1	https://doi.org/10.1111/j.1471-4159.2006.04426.x	https://doi.org/10.1111/j.1471-4159.2006.04426.x	ADJ
fnp-3806	1563	2	glabe	glabe	PROPN
fnp-3806	1563	3	cg	cg	NOUN
fnp-3806	1563	4	,	,	PUNCT
fnp-3806	1563	5	kayed	kaye	VERB
fnp-3806	1563	6	r.	r.	PROPN
fnp-3806	1563	7	common	common	ADJ
fnp-3806	1563	8	structure	structure	NOUN
fnp-3806	1563	9	and	and	CCONJ
fnp-3806	1563	10	toxic	toxic	ADJ
fnp-3806	1563	11	function	function	NOUN
fnp-3806	1563	12	of	of	ADP
fnp-3806	1563	13	amyloid	amyloid	NOUN
fnp-3806	1563	14	oligomers	oligomer	NOUN
fnp-3806	1563	15	implies	imply	VERB
fnp-3806	1563	16	a	a	DET
fnp-3806	1563	17	common	common	ADJ
fnp-3806	1563	18	mechanism	mechanism	NOUN
fnp-3806	1563	19	of	of	ADP
fnp-3806	1563	20	pathogenesis	pathogenesis	NOUN
fnp-3806	1563	21	.	.	PUNCT
fnp-3806	1564	1	neurology	neurology	NOUN
fnp-3806	1564	2	2006;66	2006;66	NOUN
fnp-3806	1564	3	:	:	PUNCT
fnp-3806	1564	4	s74	s74	NOUN
fnp-3806	1564	5	-	-	SYM
fnp-3806	1564	6	8	8	NUM
fnp-3806	1564	7	.	.	PUNCT
fnp-3806	1565	1	https://doi.org/10.1212/01.wnl.0000192103.24796.42	https://doi.org/10.1212/01.wnl.0000192103.24796.42	NOUN
fnp-3806	1565	2	shankar	shankar	PROPN
fnp-3806	1565	3	gm	gm	PROPN
fnp-3806	1565	4	,	,	PUNCT
fnp-3806	1565	5	li	li	PROPN
fnp-3806	1565	6	s	s	PROPN
fnp-3806	1565	7	,	,	PUNCT
fnp-3806	1565	8	mehta	mehta	PROPN
fnp-3806	1565	9	th	th	PROPN
fnp-3806	1565	10	,	,	PUNCT
fnp-3806	1565	11	et	et	PROPN
fnp-3806	1565	12	al	al	PROPN
fnp-3806	1565	13	.	.	PUNCT
fnp-3806	1565	14	amyloid	amyloid	NOUN
fnp-3806	1565	15	-	-	PUNCT
fnp-3806	1565	16	beta	beta	NOUN
fnp-3806	1565	17	protein	protein	NOUN
fnp-3806	1565	18	dimers	dimer	NOUN
fnp-3806	1565	19	isolated	isolate	VERB
fnp-3806	1565	20	directly	directly	ADV
fnp-3806	1565	21	from	from	ADP
fnp-3806	1565	22	alzheimer	alzheimer	PROPN
fnp-3806	1565	23	's	's	PART
fnp-3806	1565	24	brains	brain	NOUN
fnp-3806	1565	25	impair	impair	VERB
fnp-3806	1565	26	synaptic	synaptic	ADJ
fnp-3806	1565	27	plasticity	plasticity	NOUN
fnp-3806	1565	28	and	and	CCONJ
fnp-3806	1565	29	memory	memory	NOUN
fnp-3806	1565	30	.	.	PUNCT
fnp-3806	1566	1	nat	nat	PROPN
fnp-3806	1566	2	med	med	PROPN
fnp-3806	1566	3	2008;14:837	2008;14:837	PROPN
fnp-3806	1566	4	-	-	PUNCT
fnp-3806	1566	5	842	842	NUM
fnp-3806	1566	6	.	.	PUNCT
fnp-3806	1567	1	https://doi.org/10.1038/nm1782	https://doi.org/10.1038/nm1782	PROPN
fnp-3806	1567	2	sengupta	sengupta	PROPN
fnp-3806	1567	3	u	u	PROPN
fnp-3806	1567	4	,	,	PUNCT
fnp-3806	1567	5	nilson	nilson	PROPN
fnp-3806	1567	6	an	an	PROPN
fnp-3806	1567	7	,	,	PUNCT
fnp-3806	1567	8	kayed	kayed	PROPN
fnp-3806	1567	9	r.	r.	PROPN
fnp-3806	1567	10	the	the	DET
fnp-3806	1567	11	role	role	NOUN
fnp-3806	1567	12	of	of	ADP
fnp-3806	1567	13	amyloid	amyloid	NOUN
fnp-3806	1567	14	-	-	PUNCT
fnp-3806	1567	15	β	β	NOUN
fnp-3806	1567	16	oligomers	oligomer	NOUN
fnp-3806	1567	17	in	in	ADP
fnp-3806	1567	18	toxicity	toxicity	NOUN
fnp-3806	1567	19	,	,	PUNCT
fnp-3806	1567	20	propagation	propagation	NOUN
fnp-3806	1567	21	,	,	PUNCT
fnp-3806	1567	22	and	and	CCONJ
fnp-3806	1567	23	immunotherapy	immunotherapy	NOUN
fnp-3806	1567	24	.	.	PUNCT
fnp-3806	1568	1	ebiomedicine	ebiomedicine	ADJ
fnp-3806	1568	2	2016;6:42	2016;6:42	PROPN
fnp-3806	1568	3	-	-	PUNCT
fnp-3806	1568	4	49	49	NUM
fnp-3806	1568	5	.	.	PUNCT
fnp-3806	1569	1	https://doi.org/10.1016/j.ebiom.2016.03.035	https://doi.org/10.1016/j.ebiom.2016.03.035	AUX
fnp-3806	1569	2	fukumoto	fukumoto	PRON
fnp-3806	1569	3	h	h	NOUN
fnp-3806	1569	4	,	,	PUNCT
fnp-3806	1569	5	tokuda	tokuda	PRON
fnp-3806	1569	6	t	t	PROPN
fnp-3806	1569	7	,	,	PUNCT
fnp-3806	1569	8	kasai	kasai	PROPN
fnp-3806	1569	9	t	t	PROPN
fnp-3806	1569	10	,	,	PUNCT
fnp-3806	1569	11	et	et	PROPN
fnp-3806	1569	12	al	al	PROPN
fnp-3806	1569	13	.	.	PROPN
fnp-3806	1569	14	high	high	ADJ
fnp-3806	1569	15	-	-	PUNCT
fnp-3806	1569	16	molecular	molecular	ADJ
fnp-3806	1569	17	-	-	PUNCT
fnp-3806	1569	18	weight	weight	NOUN
fnp-3806	1569	19	beta	beta	NOUN
fnp-3806	1569	20	-	-	PUNCT
fnp-3806	1569	21	amyloid	amyloid	NOUN
fnp-3806	1569	22	oligomers	oligomer	NOUN
fnp-3806	1569	23	are	be	AUX
fnp-3806	1569	24	elevated	elevate	VERB
fnp-3806	1569	25	in	in	ADP
fnp-3806	1569	26	cerebrospinal	cerebrospinal	ADJ
fnp-3806	1569	27	fluid	fluid	NOUN
fnp-3806	1569	28	of	of	ADP
fnp-3806	1569	29	alzheimer	alzheimer	PROPN
fnp-3806	1569	30	patients	patient	NOUN
fnp-3806	1569	31	.	.	PUNCT
fnp-3806	1570	1	faseb	faseb	PROPN
fnp-3806	1570	2	j	j	PROPN
fnp-3806	1570	3	2010;24:2716	2010;24:2716	PROPN
fnp-3806	1570	4	-	-	SYM
fnp-3806	1570	5	2726	2726	NUM
fnp-3806	1570	6	.	.	PUNCT
fnp-3806	1571	1	https://doi.org/10.1096/fj.09-150359	https://doi.org/10.1096/fj.09-150359	PROPN
fnp-3806	1571	2	esparza	esparza	PROPN
fnp-3806	1571	3	tj	tj	PROPN
fnp-3806	1571	4	,	,	PUNCT
fnp-3806	1571	5	zhao	zhao	PROPN
fnp-3806	1571	6	h	h	PROPN
fnp-3806	1571	7	,	,	PUNCT
fnp-3806	1571	8	cirrito	cirrito	PROPN
fnp-3806	1571	9	jr	jr	PROPN
fnp-3806	1571	10	,	,	PUNCT
fnp-3806	1571	11	et	et	PROPN
fnp-3806	1571	12	al	al	PROPN
fnp-3806	1571	13	.	.	PUNCT
fnp-3806	1571	14	amyloid	amyloid	PROPN
fnp-3806	1571	15	-	-	PUNCT
fnp-3806	1571	16	β	β	NOUN
fnp-3806	1571	17	oligomerization	oligomerization	NOUN
fnp-3806	1571	18	in	in	ADP
fnp-3806	1571	19	alzheimer	alzheimer	PROPN
fnp-3806	1571	20	dementia	dementia	NOUN
fnp-3806	1571	21	versus	versus	ADP
fnp-3806	1571	22	high	high	ADJ
fnp-3806	1571	23	-	-	PUNCT
fnp-3806	1571	24	pathology	pathology	NOUN
fnp-3806	1571	25	controls	control	NOUN
fnp-3806	1571	26	.	.	PUNCT
fnp-3806	1572	1	ann	ann	PROPN
fnp-3806	1572	2	neurol	neurol	PROPN
fnp-3806	1572	3	2013;73:104	2013;73:104	PROPN
fnp-3806	1572	4	-	-	PUNCT
fnp-3806	1572	5	119	119	NUM
fnp-3806	1572	6	.	.	PUNCT
fnp-3806	1573	1	https://doi.org/10.1002/ana.23748	https://doi.org/10.1002/ana.23748	PROPN
fnp-3806	1573	2	del	del	PROPN
fnp-3806	1573	3	río	río	PROPN
fnp-3806	1573	4	ja	ja	PROPN
fnp-3806	1573	5	,	,	PUNCT
fnp-3806	1573	6	ferrer	ferrer	PROPN
fnp-3806	1573	7	i	i	PROPN
fnp-3806	1573	8	,	,	PUNCT
fnp-3806	1573	9	gavín	gavín	VERB
fnp-3806	1573	10	r.	r.	PROPN
fnp-3806	1573	11	role	role	NOUN
fnp-3806	1573	12	of	of	ADP
fnp-3806	1573	13	celular	celular	ADJ
fnp-3806	1573	14	prion	prion	NOUN
fnp-3806	1573	15	protein	protein	NOUN
fnp-3806	1573	16	in	in	ADP
fnp-3806	1573	17	interneuronal	interneuronal	ADJ
fnp-3806	1573	18	amyloid	amyloid	NOUN
fnp-3806	1573	19	transmission	transmission	NOUN
fnp-3806	1573	20	.	.	PUNCT
fnp-3806	1574	1	prog	prog	PROPN
fnp-3806	1574	2	neurobiol	neurobiol	PROPN
fnp-3806	1574	3	2018;165	2018;165	NUM
fnp-3806	1574	4	-	-	PUNCT
fnp-3806	1574	5	167:87	167:87	NUM
fnp-3806	1574	6	-	-	PUNCT
fnp-3806	1574	7	102	102	NUM
fnp-3806	1574	8	.	.	PUNCT
fnp-3806	1575	1	https://doi.org/10.1016/j.pneurobio.2018.03.001	https://doi.org/10.1016/j.pneurobio.2018.03.001	PROPN
fnp-3806	1575	2	gunther	gunther	PROPN
fnp-3806	1575	3	ec	ec	PROPN
fnp-3806	1575	4	,	,	PUNCT
fnp-3806	1575	5	strittmatter	strittmatter	NOUN
fnp-3806	1575	6	sm	sm	PROPN
fnp-3806	1575	7	.	.	PUNCT
fnp-3806	1575	8	beta	beta	NOUN
fnp-3806	1575	9	-	-	PUNCT
fnp-3806	1575	10	amyloid	amyloid	NOUN
fnp-3806	1575	11	oligomers	oligomer	NOUN
fnp-3806	1575	12	and	and	CCONJ
fnp-3806	1575	13	cellular	cellular	ADJ
fnp-3806	1575	14	prion	prion	NOUN
fnp-3806	1575	15	protein	protein	NOUN
fnp-3806	1575	16	in	in	ADP
fnp-3806	1575	17	alzheimer	alzheimer	PROPN
fnp-3806	1575	18	’s	’s	PART
fnp-3806	1575	19	disease	disease	NOUN
fnp-3806	1575	20	.	.	PUNCT
fnp-3806	1576	1	j	j	PROPN
fnp-3806	1576	2	mol	mol	PROPN
fnp-3806	1576	3	.	.	PROPN
fnp-3806	1576	4	med	med	PROPN
fnp-3806	1576	5	2010	2010	NUM
fnp-3806	1576	6	;	;	PUNCT
fnp-3806	1576	7	88	88	NUM
fnp-3806	1576	8	:	:	PUNCT
fnp-3806	1576	9	331	331	NUM
fnp-3806	1576	10	-	-	SYM
fnp-3806	1576	11	338	338	NUM
fnp-3806	1576	12	.	.	PUNCT
fnp-3806	1577	1	https://doi.org/10.1007/s00109-009-0568-7	https://doi.org/10.1007/s00109-009-0568-7	NOUN
fnp-3806	1577	2	dohler	dohler	NOUN
fnp-3806	1577	3	f	f	PROPN
fnp-3806	1577	4	,	,	PUNCT
fnp-3806	1577	5	sepulveda	sepulveda	PROPN
fnp-3806	1577	6	-	-	PUNCT
fnp-3806	1577	7	falla	falla	PROPN
fnp-3806	1577	8	d	d	PROPN
fnp-3806	1577	9	,	,	PUNCT
fnp-3806	1577	10	krasemann	krasemann	PROPN
fnp-3806	1577	11	s	s	PROPN
fnp-3806	1577	12	,	,	PUNCT
fnp-3806	1577	13	et	et	PROPN
fnp-3806	1577	14	al	al	PROPN
fnp-3806	1577	15	.	.	PROPN
fnp-3806	1578	1	high	high	PROPN
fnp-3806	1578	2	molecular	molecular	ADJ
fnp-3806	1578	3	mass	mass	NOUN
fnp-3806	1578	4	assemblies	assembly	NOUN
fnp-3806	1578	5	of	of	ADP
fnp-3806	1578	6	amyloid	amyloid	NOUN
fnp-3806	1578	7	-	-	PUNCT
fnp-3806	1578	8	beta	beta	NOUN
fnp-3806	1578	9	oligomers	oligomer	NOUN
fnp-3806	1578	10	bind	bind	VERB
fnp-3806	1578	11	prion	prion	NOUN
fnp-3806	1578	12	protein	protein	NOUN
fnp-3806	1578	13	in	in	ADP
fnp-3806	1578	14	patients	patient	NOUN
fnp-3806	1578	15	with	with	ADP
fnp-3806	1578	16	alzheimer	alzheimer	PROPN
fnp-3806	1578	17	’s	’s	PART
fnp-3806	1578	18	disease	disease	NOUN
fnp-3806	1578	19	.	.	PUNCT
fnp-3806	1579	1	brain	brain	NOUN
fnp-3806	1579	2	2014	2014	NUM
fnp-3806	1579	3	;	;	PUNCT
fnp-3806	1579	4	137	137	NUM
fnp-3806	1579	5	:	:	PUNCT
fnp-3806	1579	6	873	873	NUM
fnp-3806	1579	7	-	-	NUM
fnp-3806	1579	8	886	886	NUM
fnp-3806	1579	9	.	.	PUNCT
fnp-3806	1580	1	https://doi.org/10.1093/brain/awt375	https://doi.org/10.1093/brain/awt375	ADJ
fnp-3806	1580	2	fluharty	fluharty	NUM
fnp-3806	1580	3	br	br	PROPN
fnp-3806	1580	4	,	,	PUNCT
fnp-3806	1580	5	biasini	biasini	PROPN
fnp-3806	1580	6	e	e	PROPN
fnp-3806	1580	7	,	,	PUNCT
fnp-3806	1580	8	stravalaci	stravalaci	PROPN
fnp-3806	1580	9	m	m	PROPN
fnp-3806	1580	10	,	,	PUNCT
fnp-3806	1580	11	et	et	PROPN
fnp-3806	1580	12	al	al	PROPN
fnp-3806	1580	13	.	.	PUNCT
fnp-3806	1581	1	an	an	DET
fnp-3806	1581	2	n	n	CCONJ
fnp-3806	1581	3	-	-	PUNCT
fnp-3806	1581	4	terminal	terminal	ADJ
fnp-3806	1581	5	fragment	fragment	NOUN
fnp-3806	1581	6	of	of	ADP
fnp-3806	1581	7	the	the	DET
fnp-3806	1581	8	prion	prion	NOUN
fnp-3806	1581	9	protein	protein	NOUN
fnp-3806	1581	10	binds	bind	VERB
fnp-3806	1581	11	to	to	ADP
fnp-3806	1581	12	amyloid	amyloid	NOUN
fnp-3806	1581	13	-	-	PUNCT
fnp-3806	1581	14	beta	beta	NOUN
fnp-3806	1581	15	oligomers	oligomer	NOUN
fnp-3806	1581	16	and	and	CCONJ
fnp-3806	1581	17	inhibits	inhibit	VERB
fnp-3806	1581	18	their	their	PRON
fnp-3806	1581	19	neurotoxicity	neurotoxicity	NOUN
fnp-3806	1581	20	in	in	ADP
fnp-3806	1581	21	vivo	vivo	NOUN
fnp-3806	1581	22	.	.	PUNCT
fnp-3806	1582	1	j	j	PROPN
fnp-3806	1582	2	biol	biol	PROPN
fnp-3806	1582	3	chem	chem	NOUN
fnp-3806	1582	4	2013;288:7857	2013;288:7857	NUM
fnp-3806	1582	5	-	-	SYM
fnp-3806	1582	6	7866	7866	NUM
fnp-3806	1582	7	.	.	PUNCT
fnp-3806	1583	1	https://doi.org/10.1074/jbc.m112.423954	https://doi.org/10.1074/jbc.m112.423954	VERB
fnp-3806	1583	2	freir	freir	PROPN
fnp-3806	1583	3	db	db	PROPN
fnp-3806	1583	4	,	,	PUNCT
fnp-3806	1583	5	nicoll	nicoll	PROPN
fnp-3806	1583	6	aj	aj	PROPN
fnp-3806	1583	7	,	,	PUNCT
fnp-3806	1583	8	klyubin	klyubin	PROPN
fnp-3806	1583	9	i	i	PROPN
fnp-3806	1583	10	,	,	PUNCT
fnp-3806	1584	1	et	et	PROPN
fnp-3806	1584	2	al	al	PROPN
fnp-3806	1584	3	.	.	PUNCT
fnp-3806	1584	4	interaction	interaction	NOUN
fnp-3806	1584	5	between	between	ADP
fnp-3806	1584	6	prion	prion	NOUN
fnp-3806	1584	7	protein	protein	NOUN
fnp-3806	1584	8	and	and	CCONJ
fnp-3806	1584	9	toxic	toxic	ADJ
fnp-3806	1584	10	amyloid	amyloid	NOUN
fnp-3806	1584	11	beta	beta	NOUN
fnp-3806	1584	12	assemblies	assembly	NOUN
fnp-3806	1584	13	can	can	AUX
fnp-3806	1584	14	be	be	AUX
fnp-3806	1584	15	therapeutically	therapeutically	ADV
fnp-3806	1584	16	targeted	target	VERB
fnp-3806	1584	17	at	at	ADP
fnp-3806	1584	18	multiple	multiple	ADJ
fnp-3806	1584	19	sites	site	NOUN
fnp-3806	1584	20	.	.	PUNCT
fnp-3806	1585	1	nat	nat	PROPN
fnp-3806	1585	2	commun	commun	PROPN
fnp-3806	1585	3	2011;2:336	2011;2:336	PROPN
fnp-3806	1585	4	.	.	PUNCT
fnp-3806	1586	1	https://doi.org/10.1038/ncomms1341	https://doi.org/10.1038/ncomms1341	PROPN
fnp-3806	1586	2	ganzinger	ganzinger	PROPN
fnp-3806	1586	3	ka	ka	PROPN
fnp-3806	1586	4	,	,	PUNCT
fnp-3806	1586	5	narayan	narayan	PROPN
fnp-3806	1587	1	p	p	X
fnp-3806	1587	2	,	,	PUNCT
fnp-3806	1587	3	qamar	qamar	PROPN
fnp-3806	1587	4	ss	ss	PROPN
fnp-3806	1587	5	,	,	PUNCT
fnp-3806	1587	6	et	et	PROPN
fnp-3806	1587	7	al	al	PROPN
fnp-3806	1587	8	.	.	PUNCT
fnp-3806	1587	9	single	single	ADJ
fnp-3806	1587	10	-	-	PUNCT
fnp-3806	1587	11	molecule	molecule	NOUN
fnp-3806	1587	12	imaging	imaging	NOUN
fnp-3806	1587	13	reveals	reveal	VERB
fnp-3806	1587	14	that	that	SCONJ
fnp-3806	1587	15	small	small	ADJ
fnp-3806	1587	16	amyloid	amyloid	NOUN
fnp-3806	1587	17	-	-	PUNCT
fnp-3806	1587	18	beta1	beta1	NOUN
fnp-3806	1587	19	-	-	PUNCT
fnp-3806	1587	20	42	42	NUM
fnp-3806	1587	21	oligomers	oligomer	NOUN
fnp-3806	1587	22	interact	interact	VERB
fnp-3806	1587	23	with	with	ADP
fnp-3806	1587	24	the	the	DET
fnp-3806	1587	25	cellular	cellular	ADJ
fnp-3806	1587	26	prion	prion	NOUN
fnp-3806	1587	27	protein	protein	NOUN
fnp-3806	1587	28	(	(	PUNCT
fnp-3806	1587	29	prp(c	prp(c	NOUN
fnp-3806	1587	30	)	)	PUNCT
fnp-3806	1587	31	)	)	PUNCT
fnp-3806	1587	32	.	.	PUNCT
fnp-3806	1588	1	chembiochem	chembiochem	PROPN
fnp-3806	1588	2	2014;15:2515	2014;15:2515	NUM
fnp-3806	1588	3	-	-	SYM
fnp-3806	1588	4	2521	2521	NUM
fnp-3806	1588	5	.	.	PUNCT
fnp-3806	1589	1	https://doi.org/10.1002/cbic.201402377	https://doi.org/10.1002/cbic.201402377	PROPN
fnp-3806	1589	2	lauren	lauren	PROPN
fnp-3806	1589	3	j	j	PROPN
fnp-3806	1589	4	,	,	PUNCT
fnp-3806	1589	5	gimbel	gimbel	NOUN
fnp-3806	1589	6	da	da	NOUN
fnp-3806	1589	7	,	,	PUNCT
fnp-3806	1589	8	nygaard	nygaard	NOUN
fnp-3806	1589	9	hb	hb	PROPN
fnp-3806	1589	10	,	,	PUNCT
fnp-3806	1589	11	et	et	PROPN
fnp-3806	1589	12	al	al	PROPN
fnp-3806	1589	13	.	.	PUNCT
fnp-3806	1590	1	cellular	cellular	ADJ
fnp-3806	1590	2	prion	prion	NOUN
fnp-3806	1590	3	protein	protein	NOUN
fnp-3806	1590	4	mediates	mediate	NOUN
fnp-3806	1590	5	impairment	impairment	NOUN
fnp-3806	1590	6	of	of	ADP
fnp-3806	1590	7	synaptic	synaptic	ADJ
fnp-3806	1590	8	plasticity	plasticity	NOUN
fnp-3806	1590	9	by	by	ADP
fnp-3806	1590	10	amyloid	amyloid	NOUN
fnp-3806	1590	11	-	-	PUNCT
fnp-3806	1590	12	beta	beta	NOUN
fnp-3806	1590	13	oligomers	oligomer	NOUN
fnp-3806	1590	14	.	.	PUNCT
fnp-3806	1591	1	nature	nature	NOUN
fnp-3806	1591	2	2009	2009	NUM
fnp-3806	1591	3	,	,	PUNCT
fnp-3806	1591	4	457	457	NUM
fnp-3806	1591	5	,	,	PUNCT
fnp-3806	1591	6	1128	1128	NUM
fnp-3806	1591	7	-	-	SYM
fnp-3806	1591	8	1132	1132	NUM
fnp-3806	1591	9	.	.	PUNCT
fnp-3806	1592	1	https://doi.org/10.1038/nature07761	https://doi.org/10.1038/nature07761	PROPN
fnp-3806	1592	2	hartmann	hartmann	PROPN
fnp-3806	1592	3	a	a	X
fnp-3806	1592	4	,	,	PUNCT
fnp-3806	1592	5	muth	muth	PROPN
fnp-3806	1592	6	c	c	NOUN
fnp-3806	1592	7	,	,	PUNCT
fnp-3806	1592	8	dabrowski	dabrowski	VERB
fnp-3806	1592	9	o	o	NOUN
fnp-3806	1592	10	,	,	PUNCT
fnp-3806	1592	11	et	et	PROPN
fnp-3806	1592	12	al	al	PROPN
fnp-3806	1592	13	.	.	PROPN
fnp-3806	1592	14	exosomes	exosome	NOUN
fnp-3806	1592	15	and	and	CCONJ
fnp-3806	1592	16	the	the	DET
fnp-3806	1592	17	prion	prion	NOUN
fnp-3806	1592	18	protein	protein	NOUN
fnp-3806	1592	19	:	:	PUNCT
fnp-3806	1592	20	more	more	ADJ
fnp-3806	1592	21	than	than	ADP
fnp-3806	1592	22	one	one	NUM
fnp-3806	1592	23	truth	truth	NOUN
fnp-3806	1592	24	.	.	PUNCT
fnp-3806	1593	1	front	front	ADJ
fnp-3806	1593	2	neurosci	neurosci	PROPN
fnp-3806	1593	3	2017;11:194	2017;11:194	NOUN
fnp-3806	1593	4	.	.	PUNCT
fnp-3806	1594	1	https://doi.org/10.3389/fnins.2017.00194	https://doi.org/10.3389/fnins.2017.00194	PROPN
fnp-3806	1594	2	chaudhary	chaudhary	PROPN
fnp-3806	1594	3	h	h	PROPN
fnp-3806	1594	4	,	,	PUNCT
fnp-3806	1594	5	meister	meister	PROPN
fnp-3806	1594	6	sw	sw	PROPN
fnp-3806	1594	7	,	,	PUNCT
fnp-3806	1594	8	zetterberg	zetterberg	PROPN
fnp-3806	1594	9	h	h	PROPN
fnp-3806	1594	10	,	,	PUNCT
fnp-3806	1594	11	et	et	PROPN
fnp-3806	1594	12	al	al	PROPN
fnp-3806	1594	13	.	.	PUNCT
fnp-3806	1595	1	dissecting	dissect	VERB
fnp-3806	1595	2	the	the	DET
fnp-3806	1595	3	structural	structural	ADJ
fnp-3806	1595	4	organization	organization	NOUN
fnp-3806	1595	5	of	of	ADP
fnp-3806	1595	6	multiprotein	multiprotein	VERB
fnp-3806	1595	7	amyloid	amyloid	NOUN
fnp-3806	1595	8	aggregates	aggregate	NOUN
fnp-3806	1595	9	using	use	VERB
fnp-3806	1595	10	a	a	DET
fnp-3806	1595	11	bottom	bottom	ADJ
fnp-3806	1595	12	-	-	PUNCT
fnp-3806	1595	13	up	up	ADP
fnp-3806	1595	14	approach	approach	NOUN
fnp-3806	1595	15	.	.	PUNCT
fnp-3806	1596	1	acs	acs	PROPN
fnp-3806	1596	2	chem	chem	PROPN
fnp-3806	1596	3	neurosci	neurosci	NOUN
fnp-3806	1596	4	2020;11:1447	2020;11:1447	NUM
fnp-3806	1596	5	-	-	SYM
fnp-3806	1596	6	1457	1457	NUM
fnp-3806	1596	7	.	.	PUNCT
fnp-3806	1597	1	https://doi.org/10.1021/acschemneuro.0c00110	https://doi.org/10.1021/acschemneuro.0c00110	PROPN
fnp-3806	1597	2	rahman	rahman	PROPN
fnp-3806	1597	3	mm	mm	PROPN
fnp-3806	1597	4	,	,	PUNCT
fnp-3806	1597	5	lendel	lendel	PROPN
fnp-3806	1597	6	c.	c.	PROPN
fnp-3806	1597	7	extracellular	extracellular	ADJ
fnp-3806	1597	8	protein	protein	NOUN
fnp-3806	1597	9	components	component	NOUN
fnp-3806	1597	10	of	of	ADP
fnp-3806	1597	11	amyloid	amyloid	NOUN
fnp-3806	1597	12	plaques	plaque	NOUN
fnp-3806	1597	13	and	and	CCONJ
fnp-3806	1597	14	their	their	PRON
fnp-3806	1597	15	roles	role	NOUN
fnp-3806	1597	16	in	in	ADP
fnp-3806	1597	17	alzheimer	alzheimer	PROPN
fnp-3806	1597	18	's	's	PART
fnp-3806	1597	19	disease	disease	NOUN
fnp-3806	1597	20	pathology	pathology	NOUN
fnp-3806	1597	21	.	.	PUNCT
fnp-3806	1598	1	mol	mol	ADP
fnp-3806	1598	2	neurodegener	neurodegener	PROPN
fnp-3806	1598	3	2021;16:59	2021;16:59	NUM
fnp-3806	1598	4	.	.	PUNCT
fnp-3806	1599	1	https://doi.org/10.1186/s13024-021-00465-0	https://doi.org/10.1186/s13024-021-00465-0	PROPN
fnp-3806	1600	1	ferrer	ferrer	PROPN
fnp-3806	1600	2	i	i	PRON
fnp-3806	1600	3	,	,	PUNCT
fnp-3806	1600	4	blanco	blanco	PROPN
fnp-3806	1600	5	r	r	PROPN
fnp-3806	1600	6	,	,	PUNCT
fnp-3806	1600	7	carmona	carmona	PROPN
fnp-3806	1600	8	m	m	PROPN
fnp-3806	1600	9	,	,	PUNCT
fnp-3806	1600	10	et	et	PROPN
fnp-3806	1600	11	al	al	PROPN
fnp-3806	1600	12	.	.	PROPN
fnp-3806	1600	13	prion	prion	NOUN
fnp-3806	1600	14	protein	protein	NOUN
fnp-3806	1600	15	expression	expression	NOUN
fnp-3806	1600	16	in	in	ADP
fnp-3806	1600	17	senile	senile	ADJ
fnp-3806	1600	18	plaques	plaque	NOUN
fnp-3806	1600	19	in	in	ADP
fnp-3806	1600	20	alzheimer	alzheimer	PROPN
fnp-3806	1600	21	's	's	PART
fnp-3806	1600	22	disease	disease	NOUN
fnp-3806	1600	23	.	.	PUNCT
fnp-3806	1601	1	acta	acta	PROPN
fnp-3806	1601	2	neuropathol	neuropathol	PROPN
fnp-3806	1601	3	2001;101:49	2001;101:49	NUM
fnp-3806	1601	4	-	-	SYM
fnp-3806	1601	5	56	56	NUM
fnp-3806	1601	6	.	.	PUNCT
fnp-3806	1602	1	https://doi.org/10.1007/s004010000271	https://doi.org/10.1007/s004010000271	PROPN
fnp-3806	1602	2	ferrer	ferrer	PROPN
fnp-3806	1602	3	i	i	PROPN
fnp-3806	1602	4	,	,	PUNCT
fnp-3806	1602	5	martí	martí	NOUN
fnp-3806	1602	6	e	e	PROPN
fnp-3806	1602	7	,	,	PUNCT
fnp-3806	1602	8	tortosa	tortosa	ADP
fnp-3806	1602	9	a	a	PRON
fnp-3806	1602	10	,	,	PUNCT
fnp-3806	1602	11	et	et	PROPN
fnp-3806	1602	12	al	al	PROPN
fnp-3806	1602	13	.	.	PROPN
fnp-3806	1602	14	dystrophic	dystrophic	ADJ
fnp-3806	1602	15	neurites	neurite	NOUN
fnp-3806	1602	16	of	of	ADP
fnp-3806	1602	17	senile	senile	ADJ
fnp-3806	1602	18	plaques	plaque	NOUN
fnp-3806	1602	19	are	be	AUX
fnp-3806	1602	20	defective	defective	ADJ
fnp-3806	1602	21	in	in	ADP
fnp-3806	1602	22	proteins	protein	NOUN
fnp-3806	1602	23	involved	involve	VERB
fnp-3806	1602	24	in	in	ADP
fnp-3806	1602	25	exocytosis	exocytosis	NOUN
fnp-3806	1602	26	and	and	CCONJ
fnp-3806	1602	27	neurotransmission	neurotransmission	NOUN
fnp-3806	1602	28	.	.	PUNCT
fnp-3806	1603	1	j	j	PROPN
fnp-3806	1603	2	neuropathol	neuropathol	PROPN
fnp-3806	1603	3	exp	exp	PROPN
fnp-3806	1603	4	neurol	neurol	PROPN
fnp-3806	1603	5	1998;57:218	1998;57:218	NUM
fnp-3806	1603	6	-	-	PUNCT
fnp-3806	1603	7	225	225	NUM
fnp-3806	1603	8	.	.	PUNCT
fnp-3806	1604	1	https://doi.org/10.1097/00005072-199803000-00002	https://doi.org/10.1097/00005072-199803000-00002	NOUN
fnp-3806	1604	2	lenders	lender	NOUN
fnp-3806	1604	3	mb	mb	VERB
fnp-3806	1604	4	,	,	PUNCT
fnp-3806	1604	5	peers	peers	PROPN
fnp-3806	1604	6	mc	mc	PROPN
fnp-3806	1604	7	,	,	PUNCT
fnp-3806	1604	8	tramu	tramu	VERB
fnp-3806	1604	9	g	g	PROPN
fnp-3806	1604	10	,	,	PUNCT
fnp-3806	1604	11	et	et	PROPN
fnp-3806	1604	12	al	al	PROPN
fnp-3806	1604	13	.	.	PROPN
fnp-3806	1604	14	dystrophic	dystrophic	ADJ
fnp-3806	1604	15	peptidergic	peptidergic	NOUN
fnp-3806	1604	16	neurites	neurite	NOUN
fnp-3806	1604	17	in	in	ADP
fnp-3806	1604	18	senile	senile	ADJ
fnp-3806	1604	19	plaques	plaque	NOUN
fnp-3806	1604	20	of	of	ADP
fnp-3806	1604	21	alzheimer	alzheimer	PROPN
fnp-3806	1604	22	's	's	PART
fnp-3806	1604	23	disease	disease	NOUN
fnp-3806	1604	24	hippocampus	hippocampus	NOUN
fnp-3806	1604	25	precede	precede	VERB
fnp-3806	1604	26	formation	formation	NOUN
fnp-3806	1604	27	of	of	ADP
fnp-3806	1604	28	paired	pair	VERB
fnp-3806	1604	29	helical	helical	ADJ
fnp-3806	1604	30	filaments	filament	NOUN
fnp-3806	1604	31	.	.	PUNCT
fnp-3806	1605	1	brain	brain	NOUN
fnp-3806	1605	2	res	re	NOUN
fnp-3806	1605	3	1989;481:344	1989;481:344	PROPN
fnp-3806	1605	4	-	-	SYM
fnp-3806	1605	5	349	349	NUM
fnp-3806	1605	6	.	.	PUNCT
fnp-3806	1606	1	https://doi.org/10.1016/0006-8993(89)90812-3	https://doi.org/10.1016/0006-8993(89)90812-3	PROPN
fnp-3806	1606	2	benzing	benzing	PROPN
fnp-3806	1606	3	wc	wc	PROPN
fnp-3806	1606	4	,	,	PUNCT
fnp-3806	1606	5	brady	brady	PROPN
fnp-3806	1606	6	dr	dr	PROPN
fnp-3806	1606	7	,	,	PUNCT
fnp-3806	1606	8	mufson	mufson	NOUN
fnp-3806	1606	9	ej	ej	PROPN
fnp-3806	1606	10	,	,	PUNCT
fnp-3806	1606	11	et	et	PROPN
fnp-3806	1606	12	al	al	PROPN
fnp-3806	1606	13	.	.	PROPN
fnp-3806	1606	14	evidence	evidence	NOUN
fnp-3806	1606	15	that	that	SCONJ
fnp-3806	1606	16	transmitter	transmitter	NOUN
fnp-3806	1606	17	-	-	PUNCT
fnp-3806	1606	18	containing	contain	VERB
fnp-3806	1606	19	dystrophic	dystrophic	ADJ
fnp-3806	1606	20	neurites	neurite	NOUN
fnp-3806	1606	21	precede	precede	VERB
fnp-3806	1606	22	those	those	PRON
fnp-3806	1606	23	containing	contain	VERB
fnp-3806	1606	24	paired	pair	VERB
fnp-3806	1606	25	helical	helical	ADJ
fnp-3806	1606	26	filaments	filament	NOUN
fnp-3806	1606	27	within	within	ADP
fnp-3806	1606	28	senile	senile	ADJ
fnp-3806	1606	29	plaques	plaque	NOUN
fnp-3806	1606	30	in	in	ADP
fnp-3806	1606	31	the	the	DET
fnp-3806	1606	32	entorhinal	entorhinal	ADJ
fnp-3806	1606	33	cortex	cortex	NOUN
fnp-3806	1606	34	of	of	ADP
fnp-3806	1606	35	nondemented	nondemente	VERB
fnp-3806	1606	36	elderly	elderly	ADJ
fnp-3806	1606	37	and	and	CCONJ
fnp-3806	1606	38	alzheimer	alzheimer	PROPN
fnp-3806	1606	39	's	's	PART
fnp-3806	1606	40	disease	disease	NOUN
fnp-3806	1606	41	patients	patient	NOUN
fnp-3806	1606	42	.	.	PUNCT
fnp-3806	1607	1	brain	brain	NOUN
fnp-3806	1607	2	res	re	NOUN
fnp-3806	1607	3	1993;619:55	1993;619:55	NUM
fnp-3806	1607	4	-	-	SYM
fnp-3806	1607	5	68	68	NUM
fnp-3806	1607	6	.	.	PUNCT
fnp-3806	1608	1	https://doi.org/10.1016/0006-8993(93)91595-j	https://doi.org/10.1016/0006-8993(93)91595-j	PROPN
fnp-3806	1608	2	benzing	benzing	PROPN
fnp-3806	1608	3	wc	wc	PROPN
fnp-3806	1608	4	,	,	PUNCT
fnp-3806	1608	5	ikonomovic	ikonomovic	PROPN
fnp-3806	1608	6	md	md	PROPN
fnp-3806	1608	7	,	,	PUNCT
fnp-3806	1608	8	brady	brady	PROPN
fnp-3806	1608	9	dr	dr	PROPN
fnp-3806	1608	10	,	,	PUNCT
fnp-3806	1608	11	et	et	PROPN
fnp-3806	1608	12	al	al	PROPN
fnp-3806	1608	13	.	.	PROPN
fnp-3806	1608	14	evidence	evidence	NOUN
fnp-3806	1608	15	that	that	SCONJ
fnp-3806	1608	16	transmitter	transmitter	NOUN
fnp-3806	1608	17	-	-	PUNCT
fnp-3806	1608	18	containing	contain	VERB
fnp-3806	1608	19	dystrophic	dystrophic	ADJ
fnp-3806	1608	20	neurites	neurite	NOUN
fnp-3806	1608	21	precede	precede	VERB
fnp-3806	1608	22	paired	pair	VERB
fnp-3806	1608	23	helical	helical	ADJ
fnp-3806	1608	24	filament	filament	NOUN
fnp-3806	1608	25	and	and	CCONJ
fnp-3806	1608	26	alz-50	alz-50	ADJ
fnp-3806	1608	27	formation	formation	NOUN
fnp-3806	1608	28	within	within	ADP
fnp-3806	1608	29	senile	senile	ADJ
fnp-3806	1608	30	plaques	plaque	NOUN
fnp-3806	1608	31	in	in	ADP
fnp-3806	1608	32	the	the	DET
fnp-3806	1608	33	amygdala	amygdala	NOUN
fnp-3806	1608	34	of	of	ADP
fnp-3806	1608	35	nondemented	nondemente	VERB
fnp-3806	1608	36	elderly	elderly	ADJ
fnp-3806	1608	37	and	and	CCONJ
fnp-3806	1608	38	patients	patient	NOUN
fnp-3806	1608	39	with	with	ADP
fnp-3806	1608	40	alzheimer	alzheimer	PROPN
fnp-3806	1608	41	's	's	PART
fnp-3806	1608	42	disease	disease	NOUN
fnp-3806	1608	43	.	.	PUNCT
fnp-3806	1609	1	j	j	PROPN
fnp-3806	1609	2	comp	comp	PROPN
fnp-3806	1609	3	neurol	neurol	PROPN
fnp-3806	1609	4	1993;334:176	1993;334:176	PROPN
fnp-3806	1609	5	-	-	SYM
fnp-3806	1609	6	191	191	NUM
fnp-3806	1609	7	.	.	PUNCT
fnp-3806	1610	1	https://doi.org/10.1002/cne.903340203	https://doi.org/10.1002/cne.903340203	PROPN
fnp-3806	1610	2	dickson	dickson	PROPN
fnp-3806	1610	3	dw	dw	PROPN
fnp-3806	1610	4	,	,	PUNCT
fnp-3806	1610	5	farlo	farlo	PROPN
fnp-3806	1610	6	j	j	PROPN
fnp-3806	1610	7	,	,	PUNCT
fnp-3806	1610	8	davies	davy	NOUN
fnp-3806	1610	9	p	p	X
fnp-3806	1610	10	,	,	PUNCT
fnp-3806	1610	11	et	et	PROPN
fnp-3806	1610	12	al	al	PROPN
fnp-3806	1610	13	.	.	PROPN
fnp-3806	1610	14	alzheimer	alzheimer	PROPN
fnp-3806	1610	15	's	's	PART
fnp-3806	1610	16	disease	disease	NOUN
fnp-3806	1610	17	.	.	PUNCT
fnp-3806	1611	1	a	a	DET
fnp-3806	1611	2	double	double	ADJ
fnp-3806	1611	3	-	-	PUNCT
fnp-3806	1611	4	labeling	labeling	NOUN
fnp-3806	1611	5	immunohistochemical	immunohistochemical	ADJ
fnp-3806	1611	6	study	study	NOUN
fnp-3806	1611	7	of	of	ADP
fnp-3806	1611	8	senile	senile	ADJ
fnp-3806	1611	9	plaques	plaque	NOUN
fnp-3806	1611	10	.	.	PUNCT
fnp-3806	1612	1	am	be	AUX
fnp-3806	1612	2	j	j	PROPN
fnp-3806	1612	3	pathol	pathol	NOUN
fnp-3806	1612	4	1988;132:86	1988;132:86	NUM
fnp-3806	1612	5	-	-	SYM
fnp-3806	1612	6	101	101	NUM
fnp-3806	1612	7	.	.	PUNCT
fnp-3806	1613	1	pmid	pmid	NOUN
fnp-3806	1613	2	:	:	PUNCT
fnp-3806	1613	3	2456021	2456021	NUM
fnp-3806	1613	4	.	.	PUNCT
fnp-3806	1614	1	spires	spires	PROPN
fnp-3806	1614	2	tl	tl	PROPN
fnp-3806	1614	3	,	,	PUNCT
fnp-3806	1614	4	hyman	hyman	PROPN
fnp-3806	1614	5	bt	bt	PROPN
fnp-3806	1614	6	.	.	PUNCT
fnp-3806	1614	7	neuronal	neuronal	ADJ
fnp-3806	1614	8	structure	structure	NOUN
fnp-3806	1614	9	is	be	AUX
fnp-3806	1614	10	altered	alter	VERB
fnp-3806	1614	11	by	by	ADP
fnp-3806	1614	12	amyloid	amyloid	NOUN
fnp-3806	1614	13	plaques	plaque	NOUN
fnp-3806	1614	14	.	.	PUNCT
fnp-3806	1615	1	rev	rev	PROPN
fnp-3806	1615	2	neurosci	neurosci	PROPN
fnp-3806	1615	3	.	.	PUNCT
fnp-3806	1616	1	2004;15:267	2004;15:267	NUM
fnp-3806	1616	2	-	-	PUNCT
fnp-3806	1616	3	278	278	NUM
fnp-3806	1616	4	.	.	PUNCT
fnp-3806	1617	1	https://doi.org/10.1515/revneuro	https://doi.org/10.1515/revneuro	NOUN
fnp-3806	1617	2	2004.15.4.267	2004.15.4.267	NUM
fnp-3806	1617	3	.	.	PUNCT
fnp-3806	1618	1	brion	brion	PROPN
fnp-3806	1618	2	jp	jp	PROPN
fnp-3806	1618	3	,	,	PUNCT
fnp-3806	1618	4	couck	couck	PROPN
fnp-3806	1618	5	am	am	PROPN
fnp-3806	1618	6	,	,	PUNCT
fnp-3806	1618	7	bruce	bruce	PROPN
fnp-3806	1618	8	m	m	PROPN
fnp-3806	1618	9	,	,	PUNCT
fnp-3806	1618	10	et	et	PROPN
fnp-3806	1618	11	al	al	PROPN
fnp-3806	1618	12	.	.	PROPN
fnp-3806	1618	13	synaptophysin	synaptophysin	PROPN
fnp-3806	1618	14	and	and	CCONJ
fnp-3806	1618	15	chromogranin	chromogranin	VERB
fnp-3806	1618	16	a	a	DET
fnp-3806	1618	17	immunoreactivities	immunoreactivitie	NOUN
fnp-3806	1618	18	in	in	ADP
fnp-3806	1618	19	senile	senile	ADJ
fnp-3806	1618	20	plaques	plaque	NOUN
fnp-3806	1618	21	of	of	ADP
fnp-3806	1618	22	alzheimer	alzheimer	PROPN
fnp-3806	1618	23	's	's	PART
fnp-3806	1618	24	disease	disease	NOUN
fnp-3806	1618	25	.	.	PUNCT
fnp-3806	1619	1	brain	brain	NOUN
fnp-3806	1619	2	res	re	NOUN
fnp-3806	1619	3	1991;539:143	1991;539:143	PROPN
fnp-3806	1619	4	-	-	SYM
fnp-3806	1619	5	150	150	NUM
fnp-3806	1619	6	.	.	PUNCT
fnp-3806	1620	1	https://doi.org/10.1016/0006-8993(91)90697-t	https://doi.org/10.1016/0006-8993(91)90697-t	PROPN
fnp-3806	1620	2	munoz	munoz	PROPN
fnp-3806	1620	3	dg	dg	PROPN
fnp-3806	1620	4	.	.	PUNCT
fnp-3806	1621	1	chromogranin	chromogranin	PROPN
fnp-3806	1621	2	a	a	X
fnp-3806	1621	3	-	-	PUNCT
fnp-3806	1621	4	like	like	ADJ
fnp-3806	1621	5	immunoreactive	immunoreactive	ADJ
fnp-3806	1621	6	neurites	neurite	NOUN
fnp-3806	1621	7	are	be	AUX
fnp-3806	1621	8	major	major	ADJ
fnp-3806	1621	9	constituents	constituent	NOUN
fnp-3806	1621	10	of	of	ADP
fnp-3806	1621	11	senile	senile	ADJ
fnp-3806	1621	12	plaques	plaque	NOUN
fnp-3806	1621	13	.	.	PUNCT
fnp-3806	1622	1	lab	lab	NOUN
fnp-3806	1622	2	invest	invest	VERB
fnp-3806	1622	3	1991;64:826	1991;64:826	NUM
fnp-3806	1622	4	-	-	SYM
fnp-3806	1622	5	832	832	NUM
fnp-3806	1622	6	.	.	PUNCT
fnp-3806	1623	1	pmid	pmid	NOUN
fnp-3806	1623	2	:	:	PUNCT
fnp-3806	1623	3	1710735	1710735	NUM
fnp-3806	1623	4	.	.	PUNCT
fnp-3806	1624	1	marksteiner	marksteiner	PROPN
fnp-3806	1624	2	j	j	PROPN
fnp-3806	1624	3	,	,	PUNCT
fnp-3806	1624	4	kaufmann	kaufmann	PROPN
fnp-3806	1624	5	wa	wa	PROPN
fnp-3806	1624	6	,	,	PUNCT
fnp-3806	1624	7	gurka	gurka	PROPN
fnp-3806	1624	8	p	p	PROPN
fnp-3806	1624	9	,	,	PUNCT
fnp-3806	1624	10	et	et	PROPN
fnp-3806	1624	11	al	al	PROPN
fnp-3806	1624	12	.	.	PUNCT
fnp-3806	1624	13	synaptic	synaptic	ADJ
fnp-3806	1624	14	proteins	protein	NOUN
fnp-3806	1624	15	in	in	ADP
fnp-3806	1624	16	alzheimer	alzheimer	PROPN
fnp-3806	1624	17	's	's	PART
fnp-3806	1624	18	disease	disease	NOUN
fnp-3806	1624	19	.	.	PUNCT
fnp-3806	1625	1	j	j	PROPN
fnp-3806	1625	2	mol	mol	PROPN
fnp-3806	1625	3	neurosci	neurosci	PROPN
fnp-3806	1625	4	2002;18:53	2002;18:53	NUM
fnp-3806	1625	5	-	-	SYM
fnp-3806	1625	6	63	63	NUM
fnp-3806	1625	7	.	.	PUNCT
fnp-3806	1626	1	https://doi.org/10.1385/jmn:18:1-2:53	https://doi.org/10.1385/jmn:18:1-2:53	PROPN
fnp-3806	1626	2	barranco	barranco	PROPN
fnp-3806	1626	3	n	n	CCONJ
fnp-3806	1626	4	,	,	PUNCT
fnp-3806	1626	5	plá	plá	VERB
fnp-3806	1626	6	v	v	NOUN
fnp-3806	1626	7	,	,	PUNCT
fnp-3806	1626	8	alcolea	alcolea	NOUN
fnp-3806	1626	9	d	d	NOUN
fnp-3806	1626	10	,	,	PUNCT
fnp-3806	1626	11	et	et	NOUN
fnp-3806	1626	12	https://doi.org/10.1385/jmn:18:1-2:53.al	https://doi.org/10.1385/jmn:18:1-2:53.al	NOUN
fnp-3806	1626	13	dense	dense	ADJ
fnp-3806	1626	14	core	core	NOUN
fnp-3806	1626	15	vesicle	vesicle	NOUN
fnp-3806	1626	16	markers	marker	NOUN
fnp-3806	1626	17	in	in	ADP
fnp-3806	1626	18	csf	csf	ADJ
fnp-3806	1626	19	and	and	CCONJ
fnp-3806	1626	20	cortical	cortical	ADJ
fnp-3806	1626	21	tissues	tissue	NOUN
fnp-3806	1626	22	of	of	ADP
fnp-3806	1626	23	patients	patient	NOUN
fnp-3806	1626	24	with	with	ADP
fnp-3806	1626	25	alzheimer	alzheimer	PROPN
fnp-3806	1626	26	's	's	PART
fnp-3806	1626	27	disease	disease	NOUN
fnp-3806	1626	28	.	.	PUNCT
fnp-3806	1627	1	transl	transl	PROPN
fnp-3806	1627	2	neurodegener	neurodegener	PROPN
fnp-3806	1627	3	2021;10:37	2021;10:37	NUM
fnp-3806	1627	4	.	.	PUNCT
fnp-3806	1628	1	https://doi.org/10.1186/s40035-021-00263-0	https://doi.org/10.1186/s40035-021-00263-0	NUM
fnp-3806	1628	2	andrés	andrés	PROPN
fnp-3806	1628	3	-	-	PUNCT
fnp-3806	1628	4	benito	benito	PROPN
fnp-3806	1628	5	p	p	PROPN
fnp-3806	1628	6	,	,	PUNCT
fnp-3806	1628	7	carmona	carmona	PROPN
fnp-3806	1628	8	m	m	PROPN
fnp-3806	1628	9	,	,	PUNCT
fnp-3806	1628	10	jordán	jordán	PROPN
fnp-3806	1628	11	pirla	pirla	PROPN
fnp-3806	1628	12	m	m	PROPN
fnp-3806	1628	13	,	,	PUNCT
fnp-3806	1628	14	et	et	PROPN
fnp-3806	1628	15	al	al	PROPN
fnp-3806	1628	16	.	.	PROPN
fnp-3806	1629	1	dysregulated	dysregulate	VERB
fnp-3806	1629	2	protein	protein	NOUN
fnp-3806	1629	3	phosphorylation	phosphorylation	NOUN
fnp-3806	1629	4	as	as	ADP
fnp-3806	1629	5	main	main	ADJ
fnp-3806	1629	6	contributor	contributor	NOUN
fnp-3806	1629	7	of	of	ADP
fnp-3806	1629	8	granulovacuolar	granulovacuolar	ADJ
fnp-3806	1629	9	degeneration	degeneration	NOUN
fnp-3806	1629	10	at	at	ADP
fnp-3806	1629	11	the	the	DET
fnp-3806	1629	12	first	first	ADJ
fnp-3806	1629	13	stages	stage	NOUN
fnp-3806	1629	14	of	of	ADP
fnp-3806	1629	15	nft	nft	PROPN
fnp-3806	1629	16	pathology	pathology	PROPN
fnp-3806	1629	17	.	.	PUNCT
fnp-3806	1630	1	neuroscience	neuroscience	NOUN
fnp-3806	1630	2	2021	2021	NUM
fnp-3806	1630	3	oct	oct	NOUN
fnp-3806	1630	4	30;s0306	30;s0306	NUM
fnp-3806	1630	5	-	-	PUNCT
fnp-3806	1630	6	4522(21)00534	4522(21)00534	NUM
fnp-3806	1630	7	-	-	PUNCT
fnp-3806	1630	8	0	0	NUM
fnp-3806	1630	9	.	.	PUNCT
fnp-3806	1631	1	https://doi.org/10.1016/j.neuroscience.2021.10.023	https://doi.org/10.1016/j.neuroscience.2021.10.023	PROPN
fnp-3806	1631	2	woodhouse	woodhouse	NOUN
fnp-3806	1631	3	a	a	PRON
fnp-3806	1631	4	,	,	PUNCT
fnp-3806	1631	5	vickers	vickers	PROPN
fnp-3806	1631	6	jc	jc	PROPN
fnp-3806	1631	7	,	,	PUNCT
fnp-3806	1631	8	dickson	dickson	PROPN
fnp-3806	1631	9	tc	tc	PROPN
fnp-3806	1631	10	.	.	PUNCT
fnp-3806	1631	11	cytoplasmic	cytoplasmic	ADJ
fnp-3806	1631	12	cytochrome	cytochrome	NOUN
fnp-3806	1631	13	c	c	NOUN
fnp-3806	1631	14	immunolabelling	immunolabelling	NOUN
fnp-3806	1631	15	in	in	ADP
fnp-3806	1631	16	dystrophic	dystrophic	ADJ
fnp-3806	1631	17	neurites	neurite	NOUN
fnp-3806	1631	18	in	in	ADP
fnp-3806	1631	19	alzheimer	alzheimer	PROPN
fnp-3806	1631	20	's	's	PART
fnp-3806	1631	21	disease	disease	NOUN
fnp-3806	1631	22	.	.	PUNCT
fnp-3806	1632	1	acta	acta	PROPN
fnp-3806	1632	2	neuropathol	neuropathol	PROPN
fnp-3806	1632	3	2006;112:429	2006;112:429	NUM
fnp-3806	1632	4	-	-	SYM
fnp-3806	1632	5	437	437	NUM
fnp-3806	1632	6	.	.	PUNCT
fnp-3806	1633	1	https://doi.org/10.1007/s00401-006-0107-3	https://doi.org/10.1007/s00401-006-0107-3	PROPN
fnp-3806	1633	2	pérez	pérez	NOUN
fnp-3806	1633	3	-	-	PUNCT
fnp-3806	1633	4	gracia	gracia	PROPN
fnp-3806	1633	5	e	e	NOUN
fnp-3806	1633	6	,	,	PUNCT
fnp-3806	1633	7	torrejón	torrejón	NOUN
fnp-3806	1633	8	-	-	PUNCT
fnp-3806	1633	9	escribano	escribano	ADJ
fnp-3806	1633	10	b	b	PROPN
fnp-3806	1633	11	,	,	PUNCT
fnp-3806	1633	12	ferrer	ferrer	PROPN
fnp-3806	1633	13	i.	i.	PROPN
fnp-3806	1633	14	dystrophic	dystrophic	PROPN
fnp-3806	1633	15	neurites	neurite	NOUN
fnp-3806	1633	16	of	of	ADP
fnp-3806	1633	17	senile	senile	ADJ
fnp-3806	1633	18	plaques	plaque	NOUN
fnp-3806	1633	19	in	in	ADP
fnp-3806	1633	20	alzheimer	alzheimer	PROPN
fnp-3806	1633	21	's	's	PART
fnp-3806	1633	22	disease	disease	NOUN
fnp-3806	1633	23	are	be	AUX
fnp-3806	1633	24	deficient	deficient	ADJ
fnp-3806	1633	25	in	in	ADP
fnp-3806	1633	26	cytochrome	cytochrome	PROPN
fnp-3806	1633	27	c	c	PROPN
fnp-3806	1633	28	oxidase	oxidase	NOUN
fnp-3806	1633	29	.	.	PUNCT
fnp-3806	1634	1	https://doi.org/10.1007/s00401-008-0370-6	https://doi.org/10.1007/s00401-008-0370-6	PROPN
fnp-3806	1634	2	armstrong	armstrong	PROPN
fnp-3806	1634	3	dm	dm	PROPN
fnp-3806	1634	4	,	,	PUNCT
fnp-3806	1634	5	bruce	bruce	PROPN
fnp-3806	1634	6	g	g	PROPN
fnp-3806	1634	7	,	,	PUNCT
fnp-3806	1634	8	hersh	hersh	PROPN
fnp-3806	1634	9	lb	lb	PROPN
fnp-3806	1634	10	,	,	PUNCT
fnp-3806	1634	11	et	et	PROPN
fnp-3806	1634	12	al	al	PROPN
fnp-3806	1634	13	.	.	PROPN
fnp-3806	1634	14	choline	choline	PROPN
fnp-3806	1634	15	acetyltransferase	acetyltransferase	PROPN
fnp-3806	1634	16	immunoreactivity	immunoreactivity	PROPN
fnp-3806	1634	17	in	in	ADP
fnp-3806	1634	18	neuritic	neuritic	ADJ
fnp-3806	1634	19	plaques	plaque	NOUN
fnp-3806	1634	20	of	of	ADP
fnp-3806	1634	21	alzheimer	alzheimer	PROPN
fnp-3806	1634	22	brain	brain	NOUN
fnp-3806	1634	23	.	.	PUNCT
fnp-3806	1635	1	neurosci	neurosci	PROPN
fnp-3806	1635	2	lett	lett	PROPN
fnp-3806	1635	3	1986;71:229	1986;71:229	PROPN
fnp-3806	1635	4	-	-	PUNCT
fnp-3806	1635	5	234	234	NUM
fnp-3806	1635	6	.	.	PUNCT
fnp-3806	1636	1	https://doi.org/10.1016/0304-3940(86)90564-1	https://doi.org/10.1016/0304-3940(86)90564-1	PROPN
fnp-3806	1636	2	masliah	masliah	PROPN
fnp-3806	1636	3	e	e	PROPN
fnp-3806	1636	4	,	,	PUNCT
fnp-3806	1636	5	mallory	mallory	PROPN
fnp-3806	1636	6	m	m	PROPN
fnp-3806	1636	7	,	,	PUNCT
fnp-3806	1636	8	deteresa	deteresa	PROPN
fnp-3806	1636	9	r	r	NOUN
fnp-3806	1636	10	,	,	PUNCT
fnp-3806	1636	11	et	et	PROPN
fnp-3806	1636	12	al	al	PROPN
fnp-3806	1636	13	.	.	PUNCT
fnp-3806	1637	1	differing	differ	VERB
fnp-3806	1637	2	patterns	pattern	NOUN
fnp-3806	1637	3	of	of	ADP
fnp-3806	1637	4	aberrant	aberrant	ADJ
fnp-3806	1637	5	neuronal	neuronal	ADJ
fnp-3806	1637	6	sprouting	sprouting	NOUN
fnp-3806	1637	7	in	in	ADP
fnp-3806	1637	8	alzheimer	alzheimer	PROPN
fnp-3806	1637	9	's	's	PART
fnp-3806	1637	10	disease	disease	NOUN
fnp-3806	1637	11	with	with	ADP
fnp-3806	1637	12	and	and	CCONJ
fnp-3806	1637	13	without	without	ADP
fnp-3806	1637	14	lewy	lewy	PROPN
fnp-3806	1637	15	bodies	body	NOUN
fnp-3806	1637	16	.	.	PUNCT
fnp-3806	1638	1	brain	brain	NOUN
fnp-3806	1638	2	res	re	NOUN
fnp-3806	1638	3	1993;617:258	1993;617:258	NUM
fnp-3806	1638	4	-	-	SYM
fnp-3806	1638	5	266	266	NUM
fnp-3806	1638	6	.	.	PUNCT
fnp-3806	1639	1	https://doi.org/10.1016/0006-8993(93)91093-8	https://doi.org/10.1016/0006-8993(93)91093-8	ADV
fnp-3806	1639	2	ferrer	ferrer	PROPN
fnp-3806	1639	3	i	i	PROPN
fnp-3806	1639	4	,	,	PUNCT
fnp-3806	1639	5	zújar	zújar	PROPN
fnp-3806	1639	6	mj	mj	PROPN
fnp-3806	1639	7	,	,	PUNCT
fnp-3806	1639	8	rivera	rivera	PROPN
fnp-3806	1639	9	r	r	PROPN
fnp-3806	1639	10	,	,	PUNCT
fnp-3806	1639	11	et	et	PROPN
fnp-3806	1639	12	al	al	PROPN
fnp-3806	1639	13	.	.	PUNCT
fnp-3806	1639	14	parvalmunin	parvalmunin	PROPN
fnp-3806	1639	15	-	-	PUNCT
fnp-3806	1639	16	immunoreactive	immunoreactive	ADJ
fnp-3806	1639	17	dystrophic	dystrophic	ADJ
fnp-3806	1639	18	neurites	neurite	NOUN
fnp-3806	1639	19	and	and	CCONJ
fnp-3806	1639	20	aberrant	aberrant	ADJ
fnp-3806	1639	21	sprouts	sprout	NOUN
fnp-3806	1639	22	in	in	ADP
fnp-3806	1639	23	the	the	DET
fnp-3806	1639	24	cerebral	cerebral	ADJ
fnp-3806	1639	25	cortex	cortex	NOUN
fnp-3806	1639	26	of	of	ADP
fnp-3806	1639	27	patients	patient	NOUN
fnp-3806	1639	28	with	with	ADP
fnp-3806	1639	29	alzheimer	alzheimer	PROPN
fnp-3806	1639	30	’s	’s	PART
fnp-3806	1639	31	disease	disease	NOUN
fnp-3806	1639	32	.	.	PUNCT
fnp-3806	1640	1	neurosci	neurosci	PROPN
fnp-3806	1640	2	lett	lett	PROPN
fnp-3806	1640	3	1993;158:163	1993;158:163	NUM
fnp-3806	1640	4	-	-	SYM
fnp-3806	1640	5	166	166	NUM
fnp-3806	1640	6	.	.	PUNCT
fnp-3806	1641	1	https://doi.org/10.1016/0304-3940(93)90254-i	https://doi.org/10.1016/0304-3940(93)90254-i	PROPN
fnp-3806	1641	2	adams	adams	PROPN
fnp-3806	1641	3	la	la	PROPN
fnp-3806	1641	4	,	,	PUNCT
fnp-3806	1641	5	munoz	munoz	PROPN
fnp-3806	1641	6	dg	dg	PROPN
fnp-3806	1641	7	.	.	PUNCT
fnp-3806	1642	1	differential	differential	ADJ
fnp-3806	1642	2	incorporation	incorporation	NOUN
fnp-3806	1642	3	of	of	ADP
fnp-3806	1642	4	processes	process	NOUN
fnp-3806	1642	5	derived	derive	VERB
fnp-3806	1642	6	from	from	ADP
fnp-3806	1642	7	different	different	ADJ
fnp-3806	1642	8	classes	class	NOUN
fnp-3806	1642	9	of	of	ADP
fnp-3806	1642	10	neurons	neuron	NOUN
fnp-3806	1642	11	into	into	ADP
fnp-3806	1642	12	senile	senile	ADJ
fnp-3806	1642	13	plaques	plaque	NOUN
fnp-3806	1642	14	in	in	ADP
fnp-3806	1642	15	alzheimer	alzheimer	PROPN
fnp-3806	1642	16	's	's	PART
fnp-3806	1642	17	disease	disease	NOUN
fnp-3806	1642	18	.	.	PUNCT
fnp-3806	1643	1	acta	acta	PROPN
fnp-3806	1643	2	neuropathol	neuropathol	PROPN
fnp-3806	1643	3	1993;86:365	1993;86:365	NOUN
fnp-3806	1643	4	-	-	SYM
fnp-3806	1643	5	370	370	NUM
fnp-3806	1643	6	.	.	PUNCT
fnp-3806	1644	1	https://doi.org/10.1007/bf00369449	https://doi.org/10.1007/bf00369449	ADP
fnp-3806	1644	2	dickson	dickson	PROPN
fnp-3806	1644	3	tc	tc	PROPN
fnp-3806	1644	4	,	,	PUNCT
fnp-3806	1644	5	king	king	PROPN
fnp-3806	1644	6	ce	ce	PROPN
fnp-3806	1644	7	,	,	PUNCT
fnp-3806	1644	8	mccormack	mccormack	PROPN
fnp-3806	1644	9	gh	gh	PROPN
fnp-3806	1644	10	,	,	PUNCT
fnp-3806	1644	11	et	et	PROPN
fnp-3806	1644	12	al	al	PROPN
fnp-3806	1644	13	.	.	PUNCT
fnp-3806	1644	14	neurochemical	neurochemical	ADJ
fnp-3806	1644	15	diversity	diversity	NOUN
fnp-3806	1644	16	of	of	ADP
fnp-3806	1644	17	dystrophic	dystrophic	ADJ
fnp-3806	1644	18	neurites	neurite	NOUN
fnp-3806	1644	19	in	in	ADP
fnp-3806	1644	20	the	the	DET
fnp-3806	1644	21	early	early	ADJ
fnp-3806	1644	22	and	and	CCONJ
fnp-3806	1644	23	late	late	ADJ
fnp-3806	1644	24	stages	stage	NOUN
fnp-3806	1644	25	of	of	ADP
fnp-3806	1644	26	alzheimer	alzheimer	PROPN
fnp-3806	1644	27	’s	’s	PART
fnp-3806	1644	28	disease	disease	NOUN
fnp-3806	1644	29	.	.	PUNCT
fnp-3806	1645	1	exp	exp	NOUN
fnp-3806	1645	2	neurol	neurol	PROPN
fnp-3806	1645	3	1999;156:100	1999;156:100	NUM
fnp-3806	1645	4	-	-	SYM
fnp-3806	1645	5	110	110	NUM
fnp-3806	1645	6	.	.	PUNCT
fnp-3806	1646	1	https://doi.org/10.1006/exnr.1998.7010	https://doi.org/10.1006/exnr.1998.7010	PROPN
fnp-3806	1646	2	adlard	adlard	PROPN
fnp-3806	1646	3	pa	pa	PROPN
fnp-3806	1646	4	,	,	PUNCT
fnp-3806	1646	5	vickers	vickers	PROPN
fnp-3806	1646	6	jc	jc	PROPN
fnp-3806	1646	7	.	.	PROPN
fnp-3806	1646	8	morphologically	morphologically	ADV
fnp-3806	1646	9	distinct	distinct	ADJ
fnp-3806	1646	10	plaque	plaque	NOUN
fnp-3806	1646	11	-	-	PUNCT
fnp-3806	1646	12	types	type	NOUN
fnp-3806	1646	13	differentially	differentially	ADV
fnp-3806	1646	14	affect	affect	VERB
fnp-3806	1646	15	dendritic	dendritic	ADJ
fnp-3806	1646	16	structure	structure	NOUN
fnp-3806	1646	17	and	and	CCONJ
fnp-3806	1646	18	organisation	organisation	NOUN
fnp-3806	1646	19	in	in	ADP
fnp-3806	1646	20	the	the	DET
fnp-3806	1646	21	early	early	ADJ
fnp-3806	1646	22	and	and	CCONJ
fnp-3806	1646	23	late	late	ADJ
fnp-3806	1646	24	stages	stage	NOUN
fnp-3806	1646	25	of	of	ADP
fnp-3806	1646	26	alzheimer	alzheimer	PROPN
fnp-3806	1646	27	’s	’s	PART
fnp-3806	1646	28	disease	disease	NOUN
fnp-3806	1646	29	.	.	PUNCT
fnp-3806	1647	1	acta	acta	PROPN
fnp-3806	1647	2	neuropathol	neuropathol	PROPN
fnp-3806	1647	3	2002;103:377	2002;103:377	NUM
fnp-3806	1647	4	-	-	SYM
fnp-3806	1647	5	383	383	NUM
fnp-3806	1647	6	.	.	PUNCT
fnp-3806	1648	1	https://doi.org/10.1007/s00401-001-0476-6	https://doi.org/10.1007/s00401-001-0476-6	NUM
fnp-3806	1648	2	spires	spire	NOUN
fnp-3806	1648	3	tl	tl	PROPN
fnp-3806	1648	4	,	,	PUNCT
fnp-3806	1648	5	meyer	meyer	PROPN
fnp-3806	1648	6	-	-	PUNCT
fnp-3806	1648	7	luehmann	luehmann	PROPN
fnp-3806	1648	8	m	m	PROPN
fnp-3806	1648	9	,	,	PUNCT
fnp-3806	1648	10	stern	stern	PROPN
fnp-3806	1648	11	ea	ea	PROPN
fnp-3806	1648	12	,	,	PUNCT
fnp-3806	1648	13	et	et	PROPN
fnp-3806	1648	14	al	al	PROPN
fnp-3806	1648	15	.	.	PUNCT
fnp-3806	1649	1	dendritic	dendritic	ADJ
fnp-3806	1649	2	spine	spine	ADJ
fnp-3806	1649	3	abnormalities	abnormality	NOUN
fnp-3806	1649	4	in	in	ADP
fnp-3806	1649	5	amyloid	amyloid	NOUN
fnp-3806	1649	6	precursor	precursor	NOUN
fnp-3806	1649	7	protein	protein	NOUN
fnp-3806	1649	8	transgenic	transgenic	NOUN
fnp-3806	1649	9	mice	mouse	NOUN
fnp-3806	1649	10	demonstrated	demonstrate	VERB
fnp-3806	1649	11	by	by	ADP
fnp-3806	1649	12	gene	gene	NOUN
fnp-3806	1649	13	transfer	transfer	NOUN
fnp-3806	1649	14	and	and	CCONJ
fnp-3806	1649	15	intravital	intravital	ADJ
fnp-3806	1649	16	multiphoton	multiphoton	NOUN
fnp-3806	1649	17	microscopy	microscopy	NOUN
fnp-3806	1649	18	.	.	PUNCT
fnp-3806	1650	1	j	j	PROPN
fnp-3806	1650	2	neurosci	neurosci	VERB
fnp-3806	1650	3	2005;25:7278	2005;25:7278	NUM
fnp-3806	1650	4	-	-	SYM
fnp-3806	1650	5	7287	7287	NUM
fnp-3806	1650	6	.	.	PUNCT
fnp-3806	1651	1	https://doi.org/10.1523/jneurosci.1879-05.2005	https://doi.org/10.1523/jneurosci.1879-05.2005	PROPN
fnp-3806	1651	2	knafo	knafo	PROPN
fnp-3806	1651	3	s	s	PROPN
fnp-3806	1651	4	,	,	PUNCT
fnp-3806	1651	5	alonso	alonso	NOUN
fnp-3806	1651	6	-	-	PUNCT
fnp-3806	1651	7	nanclares	nanclare	NOUN
fnp-3806	1651	8	l	l	NOUN
fnp-3806	1651	9	,	,	PUNCT
fnp-3806	1651	10	gonzalez	gonzalez	PROPN
fnp-3806	1651	11	-	-	PUNCT
fnp-3806	1651	12	soriano	soriano	PROPN
fnp-3806	1651	13	j	j	PROPN
fnp-3806	1651	14	,	,	PUNCT
fnp-3806	1651	15	et	et	PROPN
fnp-3806	1651	16	al	al	PROPN
fnp-3806	1651	17	.	.	PROPN
fnp-3806	1652	1	widespread	widespread	ADJ
fnp-3806	1652	2	changes	change	NOUN
fnp-3806	1652	3	in	in	ADP
fnp-3806	1652	4	dendritic	dendritic	ADJ
fnp-3806	1652	5	spines	spine	NOUN
fnp-3806	1652	6	in	in	ADP
fnp-3806	1652	7	a	a	DET
fnp-3806	1652	8	model	model	NOUN
fnp-3806	1652	9	of	of	ADP
fnp-3806	1652	10	alzheimer	alzheimer	PROPN
fnp-3806	1652	11	's	's	PART
fnp-3806	1652	12	disease	disease	NOUN
fnp-3806	1652	13	.	.	PUNCT
fnp-3806	1653	1	cereb	cereb	PROPN
fnp-3806	1653	2	cortex	cortex	NOUN
fnp-3806	1653	3	.	.	PUNCT
fnp-3806	1654	1	2009;19:586	2009;19:586	NUM
fnp-3806	1654	2	-	-	SYM
fnp-3806	1654	3	592	592	NUM
fnp-3806	1654	4	.	.	PUNCT
fnp-3806	1655	1	https://doi.org/10.1093/cercor/bhn111	https://doi.org/10.1093/cercor/bhn111	PROPN
fnp-3806	1655	2	robbins	robbins	PROPN
fnp-3806	1655	3	m	m	PROPN
fnp-3806	1655	4	,	,	PUNCT
fnp-3806	1655	5	clayton	clayton	PROPN
fnp-3806	1655	6	e	e	PROPN
fnp-3806	1655	7	,	,	PUNCT
fnp-3806	1655	8	kaminski	kaminski	PROPN
fnp-3806	1655	9	schierle	schierle	PROPN
fnp-3806	1655	10	gs	gs	PROPN
fnp-3806	1655	11	.	.	PUNCT
fnp-3806	1655	12	synaptic	synaptic	PROPN
fnp-3806	1655	13	tau	tau	PROPN
fnp-3806	1655	14	:	:	PUNCT
fnp-3806	1655	15	a	a	DET
fnp-3806	1655	16	pathological	pathological	ADJ
fnp-3806	1655	17	or	or	CCONJ
fnp-3806	1655	18	physiological	physiological	ADJ
fnp-3806	1655	19	phenomenon	phenomenon	NOUN
fnp-3806	1655	20	?	?	PUNCT
fnp-3806	1656	1	acta	acta	PROPN
fnp-3806	1656	2	neuropathol	neuropathol	PROPN
fnp-3806	1656	3	commun	commun	PROPN
fnp-3806	1656	4	2021;9:149	2021;9:149	PROPN
fnp-3806	1656	5	.	.	PUNCT
fnp-3806	1657	1	https://doi.org/10.1186/s40478-021-01246-y	https://doi.org/10.1186/s40478-021-01246-y	PROPN
fnp-3806	1657	2	alquezar	alquezar	PROPN
fnp-3806	1657	3	c	c	PROPN
fnp-3806	1657	4	,	,	PUNCT
fnp-3806	1657	5	arya	arya	PROPN
fnp-3806	1657	6	s	s	PROPN
fnp-3806	1657	7	,	,	PUNCT
fnp-3806	1657	8	kao	kao	PROPN
fnp-3806	1657	9	aw	aw	INTJ
fnp-3806	1657	10	.	.	PROPN
fnp-3806	1658	1	tau	tau	PROPN
fnp-3806	1658	2	post	post	ADJ
fnp-3806	1658	3	-	-	ADJ
fnp-3806	1658	4	translational	translational	ADJ
fnp-3806	1658	5	modifications	modification	NOUN
fnp-3806	1658	6	:	:	PUNCT
fnp-3806	1658	7	dynamic	dynamic	ADJ
fnp-3806	1658	8	transformers	transformer	NOUN
fnp-3806	1658	9	of	of	ADP
fnp-3806	1658	10	tau	tau	PROPN
fnp-3806	1658	11	function	function	NOUN
fnp-3806	1658	12	,	,	PUNCT
fnp-3806	1658	13	degradation	degradation	NOUN
fnp-3806	1658	14	,	,	PUNCT
fnp-3806	1658	15	and	and	CCONJ
fnp-3806	1658	16	aggregation	aggregation	NOUN
fnp-3806	1658	17	.	.	PUNCT
fnp-3806	1659	1	front	front	ADJ
fnp-3806	1659	2	neurol	neurol	NOUN
fnp-3806	1659	3	2021;11:595532	2021;11:595532	NUM
fnp-3806	1659	4	.	.	PUNCT
fnp-3806	1660	1	https://doi.org/10.3389/fneur.2020.595532	https://doi.org/10.3389/fneur.2020.595532	PROPN
fnp-3806	1660	2	hernández	hernández	PROPN
fnp-3806	1660	3	f	f	PROPN
fnp-3806	1660	4	,	,	PUNCT
fnp-3806	1660	5	avila	avila	PROPN
fnp-3806	1660	6	j.	j.	PROPN
fnp-3806	1660	7	intraand	intraand	PROPN
fnp-3806	1660	8	extracellular	extracellular	ADJ
fnp-3806	1660	9	protein	protein	NOUN
fnp-3806	1660	10	interactions	interaction	NOUN
fnp-3806	1660	11	with	with	ADP
fnp-3806	1660	12	tau	tau	PROPN
fnp-3806	1660	13	.	.	PUNCT
fnp-3806	1661	1	curr	curr	PROPN
fnp-3806	1661	2	alzheimer	alzheimer	PROPN
fnp-3806	1661	3	res	res	PROPN
fnp-3806	1661	4	2010;7:670	2010;7:670	PROPN
fnp-3806	1661	5	-	-	SYM
fnp-3806	1661	6	676	676	NUM
fnp-3806	1661	7	.	.	PUNCT
fnp-3806	1662	1	https://doi.org/10.2174/156720510793611583	https://doi.org/10.2174/156720510793611583	NOUN
fnp-3806	1662	2	rauch	rauch	PROPN
fnp-3806	1662	3	jn	jn	PROPN
fnp-3806	1662	4	,	,	PUNCT
fnp-3806	1662	5	olson	olson	PROPN
fnp-3806	1662	6	sh	sh	PROPN
fnp-3806	1662	7	,	,	PUNCT
fnp-3806	1662	8	gestwicki	gestwicki	PROPN
fnp-3806	1662	9	je	je	PROPN
fnp-3806	1662	10	.	.	PUNCT
fnp-3806	1663	1	interactions	interaction	NOUN
fnp-3806	1663	2	between	between	ADP
fnp-3806	1663	3	microtubule	microtubule	NOUN
fnp-3806	1663	4	-	-	PUNCT
fnp-3806	1663	5	associated	associate	VERB
fnp-3806	1663	6	protein	protein	NOUN
fnp-3806	1663	7	tau	tau	PROPN
fnp-3806	1663	8	(	(	PUNCT
fnp-3806	1663	9	mapt	mapt	NOUN
fnp-3806	1663	10	)	)	PUNCT
fnp-3806	1663	11	and	and	CCONJ
fnp-3806	1663	12	small	small	ADJ
fnp-3806	1663	13	molecules	molecule	NOUN
fnp-3806	1663	14	.	.	PUNCT
fnp-3806	1664	1	cold	cold	ADJ
fnp-3806	1664	2	spring	spring	NOUN
fnp-3806	1664	3	harb	harb	PROPN
fnp-3806	1664	4	perspect	perspect	VERB
fnp-3806	1664	5	med	med	ADJ
fnp-3806	1664	6	2017;7	2017;7	NOUN
fnp-3806	1664	7	:	:	PUNCT
fnp-3806	1665	1	a024034	a024034	ADJ
fnp-3806	1665	2	.	.	PUNCT
fnp-3806	1666	1	https://doi.org/10.1101/cshperspect.a024034	https://doi.org/10.1101/cshperspect.a024034	PROPN
fnp-3806	1666	2	borna	borna	PROPN
fnp-3806	1666	3	h	h	PROPN
fnp-3806	1666	4	,	,	PUNCT
fnp-3806	1666	5	assadoulahei	assadoulahei	PROPN
fnp-3806	1666	6	k	k	PROPN
fnp-3806	1666	7	,	,	PUNCT
fnp-3806	1666	8	riazi	riazi	PROPN
fnp-3806	1666	9	g	g	PROPN
fnp-3806	1666	10	,	,	PUNCT
fnp-3806	1666	11	et	et	PROPN
fnp-3806	1666	12	al	al	PROPN
fnp-3806	1666	13	.	.	PROPN
fnp-3806	1666	14	structure	structure	NOUN
fnp-3806	1666	15	,	,	PUNCT
fnp-3806	1666	16	function	function	NOUN
fnp-3806	1666	17	and	and	CCONJ
fnp-3806	1666	18	interactions	interaction	NOUN
fnp-3806	1666	19	of	of	ADP
fnp-3806	1666	20	tau	tau	NOUN
fnp-3806	1666	21	:	:	PUNCT
fnp-3806	1666	22	particular	particular	ADJ
fnp-3806	1666	23	focus	focus	NOUN
fnp-3806	1666	24	on	on	ADP
fnp-3806	1666	25	potential	potential	ADJ
fnp-3806	1666	26	drug	drug	NOUN
fnp-3806	1666	27	targets	target	NOUN
fnp-3806	1666	28	for	for	ADP
fnp-3806	1666	29	the	the	DET
fnp-3806	1666	30	treatment	treatment	NOUN
fnp-3806	1666	31	of	of	ADP
fnp-3806	1666	32	tauopathies	tauopathie	NOUN
fnp-3806	1666	33	.	.	PUNCT
fnp-3806	1667	1	cns	cns	PROPN
fnp-3806	1667	2	neurol	neurol	PROPN
fnp-3806	1667	3	disord	disord	PROPN
fnp-3806	1667	4	drug	drug	NOUN
fnp-3806	1667	5	targets	target	NOUN
fnp-3806	1667	6	2018;17:325	2018;17:325	PROPN
fnp-3806	1667	7	-	-	SYM
fnp-3806	1667	8	337	337	NUM
fnp-3806	1667	9	.	.	PUNCT
fnp-3806	1668	1	https://doi.org/10.2174/1871527317666180525112008	https://doi.org/10.2174/1871527317666180525112008	NOUN
fnp-3806	1668	2	trushina	trushina	ADJ
fnp-3806	1668	3	ni	ni	PROPN
fnp-3806	1668	4	,	,	PUNCT
fnp-3806	1668	5	bakota	bakota	ADJ
fnp-3806	1668	6	l	l	NOUN
fnp-3806	1668	7	,	,	PUNCT
fnp-3806	1668	8	mulkidjanian	mulkidjanian	PROPN
fnp-3806	1668	9	ay	ay	PROPN
fnp-3806	1668	10	,	,	PUNCT
fnp-3806	1668	11	et	et	PROPN
fnp-3806	1668	12	al	al	PROPN
fnp-3806	1668	13	.	.	PUNCT
fnp-3806	1669	1	the	the	DET
fnp-3806	1669	2	evolution	evolution	NOUN
fnp-3806	1669	3	of	of	ADP
fnp-3806	1669	4	tau	tau	PROPN
fnp-3806	1669	5	phosphorylation	phosphorylation	NOUN
fnp-3806	1669	6	and	and	CCONJ
fnp-3806	1669	7	interactions	interaction	NOUN
fnp-3806	1669	8	.	.	PUNCT
fnp-3806	1670	1	front	front	ADJ
fnp-3806	1670	2	aging	age	VERB
fnp-3806	1670	3	neurosci	neurosci	NOUN
fnp-3806	1670	4	2019;11:256	2019;11:256	NUM
fnp-3806	1670	5	.	.	PUNCT
fnp-3806	1671	1	https://doi.org/10.3389/fnagi.2019.00256	https://doi.org/10.3389/fnagi.2019.00256	PROPN
fnp-3806	1671	2	brandt	brandt	PROPN
fnp-3806	1671	3	r	r	PROPN
fnp-3806	1671	4	,	,	PUNCT
fnp-3806	1671	5	trushina	trushina	PROPN
fnp-3806	1671	6	ni	ni	PROPN
fnp-3806	1671	7	,	,	PUNCT
fnp-3806	1671	8	bakota	bakota	PROPN
fnp-3806	1671	9	l.	l.	PROPN
fnp-3806	1671	10	much	much	ADV
fnp-3806	1671	11	more	more	ADJ
fnp-3806	1671	12	than	than	ADP
fnp-3806	1671	13	a	a	DET
fnp-3806	1671	14	cytoskeletal	cytoskeletal	ADJ
fnp-3806	1671	15	protein	protein	NOUN
fnp-3806	1671	16	:	:	PUNCT
fnp-3806	1671	17	physiological	physiological	ADJ
fnp-3806	1671	18	and	and	CCONJ
fnp-3806	1671	19	pathological	pathological	ADJ
fnp-3806	1671	20	functions	function	NOUN
fnp-3806	1671	21	of	of	ADP
fnp-3806	1671	22	the	the	DET
fnp-3806	1671	23	non	non	ADJ
fnp-3806	1671	24	-	-	ADJ
fnp-3806	1671	25	microtubule	microtubule	ADJ
fnp-3806	1671	26	binding	bind	VERB
fnp-3806	1671	27	region	region	NOUN
fnp-3806	1671	28	of	of	ADP
fnp-3806	1671	29	tau	tau	PROPN
fnp-3806	1671	30	.	.	PUNCT
fnp-3806	1672	1	front	front	ADJ
fnp-3806	1672	2	neurol	neurol	PROPN
fnp-3806	1672	3	2020;11:590059	2020;11:590059	NUM
fnp-3806	1672	4	.	.	PUNCT
fnp-3806	1673	1	https://doi.org/10.3389/fneur.2020.590059	https://doi.org/10.3389/fneur.2020.590059	PROPN
fnp-3806	1673	2	sinsky	sinsky	PROPN
fnp-3806	1673	3	j	j	PROPN
fnp-3806	1673	4	,	,	PUNCT
fnp-3806	1673	5	pichlerova	pichlerova	PROPN
fnp-3806	1673	6	k	k	PROPN
fnp-3806	1673	7	,	,	PUNCT
fnp-3806	1673	8	hanes	hanes	PROPN
fnp-3806	1673	9	j.	j.	PROPN
fnp-3806	1673	10	tau	tau	PROPN
fnp-3806	1673	11	protein	protein	NOUN
fnp-3806	1673	12	interaction	interaction	NOUN
fnp-3806	1673	13	partners	partner	NOUN
fnp-3806	1673	14	and	and	CCONJ
fnp-3806	1673	15	their	their	PRON
fnp-3806	1673	16	roles	role	NOUN
fnp-3806	1673	17	in	in	ADP
fnp-3806	1673	18	alzheimer	alzheimer	PROPN
fnp-3806	1673	19	's	's	PART
fnp-3806	1673	20	disease	disease	NOUN
fnp-3806	1673	21	and	and	CCONJ
fnp-3806	1673	22	other	other	ADJ
fnp-3806	1673	23	tauopathies	tauopathie	NOUN
fnp-3806	1673	24	.	.	PUNCT
fnp-3806	1674	1	int	int	PROPN
fnp-3806	1674	2	j	j	PROPN
fnp-3806	1674	3	mol	mol	ADP
fnp-3806	1674	4	sci	sci	PROPN
fnp-3806	1674	5	2021;22:9207	2021;22:9207	PROPN
fnp-3806	1674	6	.	.	PUNCT
fnp-3806	1675	1	https://doi.org/10.3390/ijms22179207	https://doi.org/10.3390/ijms22179207	PROPN
fnp-3806	1675	2	delacourte	delacourte	PROPN
fnp-3806	1675	3	a	a	PRON
fnp-3806	1675	4	,	,	PUNCT
fnp-3806	1675	5	defossez	defossez	NOUN
fnp-3806	1675	6	a.	a.	NOUN
fnp-3806	1675	7	alzheimer	alzheimer	PROPN
fnp-3806	1675	8	's	's	PART
fnp-3806	1675	9	disease	disease	NOUN
fnp-3806	1675	10	:	:	PUNCT
fnp-3806	1675	11	tau	tau	PROPN
fnp-3806	1675	12	proteins	protein	NOUN
fnp-3806	1675	13	,	,	PUNCT
fnp-3806	1675	14	the	the	DET
fnp-3806	1675	15	promoting	promote	VERB
fnp-3806	1675	16	factors	factor	NOUN
fnp-3806	1675	17	of	of	ADP
fnp-3806	1675	18	microtubule	microtubule	NOUN
fnp-3806	1675	19	assembly	assembly	NOUN
fnp-3806	1675	20	,	,	PUNCT
fnp-3806	1675	21	are	be	AUX
fnp-3806	1675	22	major	major	ADJ
fnp-3806	1675	23	components	component	NOUN
fnp-3806	1675	24	of	of	ADP
fnp-3806	1675	25	paired	pair	VERB
fnp-3806	1675	26	helical	helical	ADJ
fnp-3806	1675	27	filaments	filament	NOUN
fnp-3806	1675	28	.	.	PUNCT
fnp-3806	1676	1	j	j	PROPN
fnp-3806	1676	2	neurol	neurol	PROPN
fnp-3806	1676	3	sci	sci	PROPN
fnp-3806	1676	4	1986;76:173	1986;76:173	PROPN
fnp-3806	1676	5	-	-	PROPN
fnp-3806	1676	6	186	186	NUM
fnp-3806	1676	7	.	.	PUNCT
fnp-3806	1677	1	https://doi.org/10.1016/0022-510x(86)90167-x	https://doi.org/10.1016/0022-510x(86)90167-x	PROPN
fnp-3806	1677	2	kosik	kosik	PROPN
fnp-3806	1677	3	ks	ks	PROPN
fnp-3806	1677	4	,	,	PUNCT
fnp-3806	1677	5	joachim	joachim	PROPN
fnp-3806	1677	6	cl	cl	PROPN
fnp-3806	1677	7	,	,	PUNCT
fnp-3806	1677	8	selkoe	selkoe	ADJ
fnp-3806	1677	9	dj	dj	NOUN
fnp-3806	1677	10	.	.	PUNCT
fnp-3806	1677	11	microtubule	microtubule	NOUN
fnp-3806	1677	12	-	-	PUNCT
fnp-3806	1677	13	associated	associate	VERB
fnp-3806	1677	14	protein	protein	NOUN
fnp-3806	1677	15	tau	tau	PROPN
fnp-3806	1677	16	(	(	PUNCT
fnp-3806	1677	17	tau	tau	PROPN
fnp-3806	1677	18	)	)	PUNCT
fnp-3806	1677	19	is	be	AUX
fnp-3806	1677	20	a	a	DET
fnp-3806	1677	21	major	major	ADJ
fnp-3806	1677	22	antigenic	antigenic	ADJ
fnp-3806	1677	23	component	component	NOUN
fnp-3806	1677	24	of	of	ADP
fnp-3806	1677	25	paired	pair	VERB
fnp-3806	1677	26	helical	helical	ADJ
fnp-3806	1677	27	filaments	filament	NOUN
fnp-3806	1677	28	in	in	ADP
fnp-3806	1677	29	alzheimer	alzheimer	PROPN
fnp-3806	1677	30	disease	disease	NOUN
fnp-3806	1677	31	.	.	PUNCT
fnp-3806	1678	1	proc	proc	PROPN
fnp-3806	1678	2	natl	natl	PROPN
fnp-3806	1678	3	acad	acad	PROPN
fnp-3806	1678	4	sci	sci	PROPN
fnp-3806	1678	5	usa	usa	PROPN
fnp-3806	1678	6	1986;83:4044	1986;83:4044	PROPN
fnp-3806	1678	7	-	-	PUNCT
fnp-3806	1678	8	4048	4048	NUM
fnp-3806	1678	9	.	.	PUNCT
fnp-3806	1679	1	https://doi.org/10.1073/pnas.83.11.4044	https://doi.org/10.1073/pnas.83.11.4044	PROPN
fnp-3806	1679	2	wood	wood	PROPN
fnp-3806	1679	3	jg	jg	PROPN
fnp-3806	1679	4	,	,	PUNCT
fnp-3806	1679	5	mirra	mirra	PROPN
fnp-3806	1679	6	ss	ss	PROPN
fnp-3806	1679	7	,	,	PUNCT
fnp-3806	1679	8	pollock	pollock	PROPN
fnp-3806	1679	9	nj	nj	PROPN
fnp-3806	1679	10	,	,	PUNCT
fnp-3806	1679	11	et	et	PROPN
fnp-3806	1679	12	al	al	PROPN
fnp-3806	1679	13	.	.	PROPN
fnp-3806	1680	1	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1680	2	tangles	tangle	NOUN
fnp-3806	1680	3	of	of	ADP
fnp-3806	1680	4	alzheimer	alzheimer	PROPN
fnp-3806	1680	5	disease	disease	PROPN
fnp-3806	1680	6	share	share	VERB
fnp-3806	1680	7	antigenic	antigenic	ADJ
fnp-3806	1680	8	determinants	determinant	NOUN
fnp-3806	1680	9	with	with	ADP
fnp-3806	1680	10	the	the	DET
fnp-3806	1680	11	axonal	axonal	ADJ
fnp-3806	1680	12	microtubule	microtubule	NOUN
fnp-3806	1680	13	-	-	PUNCT
fnp-3806	1680	14	associated	associate	VERB
fnp-3806	1680	15	protein	protein	NOUN
fnp-3806	1680	16	tau	tau	PROPN
fnp-3806	1680	17	(	(	PUNCT
fnp-3806	1680	18	tau	tau	PROPN
fnp-3806	1680	19	)	)	PUNCT
fnp-3806	1680	20	.	.	PUNCT
fnp-3806	1681	1	proc	proc	PROPN
fnp-3806	1681	2	natl	natl	PROPN
fnp-3806	1681	3	acad	acad	PROPN
fnp-3806	1681	4	sci	sci	PROPN
fnp-3806	1681	5	usa	usa	PROPN
fnp-3806	1681	6	1986;83:4040	1986;83:4040	PROPN
fnp-3806	1681	7	-	-	PROPN
fnp-3806	1681	8	4043	4043	NUM
fnp-3806	1681	9	.	.	PUNCT
fnp-3806	1682	1	https://doi.org/10.1073/pnas.83.11.4040	https://doi.org/10.1073/pnas.83.11.4040	X
fnp-3806	1682	2	grundke	grundke	ADJ
fnp-3806	1682	3	-	-	PUNCT
fnp-3806	1682	4	iqbal	iqbal	NOUN
fnp-3806	1682	5	i	i	PROPN
fnp-3806	1682	6	,	,	PUNCT
fnp-3806	1682	7	iqbal	iqbal	PROPN
fnp-3806	1682	8	k	k	PROPN
fnp-3806	1682	9	,	,	PUNCT
fnp-3806	1682	10	quinlan	quinlan	PROPN
fnp-3806	1682	11	m	m	PROPN
fnp-3806	1682	12	,	,	PUNCT
fnp-3806	1682	13	et	et	PROPN
fnp-3806	1682	14	al	al	PROPN
fnp-3806	1682	15	.	.	PUNCT
fnp-3806	1682	16	microtubule	microtubule	NOUN
fnp-3806	1682	17	-	-	PUNCT
fnp-3806	1682	18	associated	associate	VERB
fnp-3806	1682	19	protein	protein	NOUN
fnp-3806	1682	20	tau	tau	NOUN
fnp-3806	1682	21	.	.	PUNCT
fnp-3806	1683	1	a	a	DET
fnp-3806	1683	2	component	component	NOUN
fnp-3806	1683	3	of	of	ADP
fnp-3806	1683	4	alzheimer	alzheimer	PROPN
fnp-3806	1683	5	paired	pair	VERB
fnp-3806	1683	6	helical	helical	ADJ
fnp-3806	1683	7	filaments	filament	NOUN
fnp-3806	1683	8	.	.	PUNCT
fnp-3806	1684	1	j	j	PROPN
fnp-3806	1684	2	biol	biol	PROPN
fnp-3806	1684	3	chem	chem	NOUN
fnp-3806	1684	4	1986;261	1986;261	NUM
fnp-3806	1684	5	:	:	PUNCT
fnp-3806	1684	6	6084	6084	NUM
fnp-3806	1684	7	-	-	SYM
fnp-3806	1684	8	6089	6089	NUM
fnp-3806	1684	9	.	.	PUNCT
fnp-3806	1685	1	pmid	pmid	NOUN
fnp-3806	1685	2	:	:	PUNCT
fnp-3806	1685	3	3084478	3084478	NUM
fnp-3806	1685	4	.	.	PUNCT
fnp-3806	1686	1	iqbal	iqbal	PROPN
fnp-3806	1686	2	k	k	PROPN
fnp-3806	1686	3	,	,	PUNCT
fnp-3806	1686	4	grundke	grundke	ADJ
fnp-3806	1686	5	-	-	PUNCT
fnp-3806	1686	6	iqbal	iqbal	NOUN
fnp-3806	1686	7	i	i	PROPN
fnp-3806	1686	8	,	,	PUNCT
fnp-3806	1686	9	wisniewski	wisniewski	PROPN
fnp-3806	1686	10	hm	hm	PROPN
fnp-3806	1686	11	.	.	PUNCT
fnp-3806	1687	1	neuronal	neuronal	ADJ
fnp-3806	1687	2	cytoskeleton	cytoskeleton	NOUN
fnp-3806	1687	3	in	in	ADP
fnp-3806	1687	4	aging	aging	NOUN
fnp-3806	1687	5	and	and	CCONJ
fnp-3806	1687	6	dementia	dementia	NOUN
fnp-3806	1687	7	.	.	PUNCT
fnp-3806	1688	1	prog	prog	NOUN
fnp-3806	1688	2	brain	brain	NOUN
fnp-3806	1688	3	res	re	NOUN
fnp-3806	1688	4	1986;70:279	1986;70:279	NOUN
fnp-3806	1688	5	-	-	SYM
fnp-3806	1688	6	288	288	NUM
fnp-3806	1688	7	.	.	PUNCT
fnp-3806	1689	1	https://doi.org/10.1016/s0079-6123(08)64310-1	https://doi.org/10.1016/s0079-6123(08)64310-1	PROPN
fnp-3806	1689	2	goedert	goedert	PROPN
fnp-3806	1689	3	m	m	PROPN
fnp-3806	1689	4	,	,	PUNCT
fnp-3806	1689	5	wischik	wischik	PROPN
fnp-3806	1689	6	cm	cm	PROPN
fnp-3806	1689	7	,	,	PUNCT
fnp-3806	1689	8	crowther	crowther	PROPN
fnp-3806	1689	9	ra	ra	PROPN
fnp-3806	1689	10	,	,	PUNCT
fnp-3806	1689	11	et	et	PROPN
fnp-3806	1689	12	al	al	PROPN
fnp-3806	1689	13	.	.	PUNCT
fnp-3806	1689	14	cloning	cloning	NOUN
fnp-3806	1689	15	and	and	CCONJ
fnp-3806	1689	16	sequencing	sequencing	NOUN
fnp-3806	1689	17	of	of	ADP
fnp-3806	1689	18	the	the	DET
fnp-3806	1689	19	cdna	cdna	PROPN
fnp-3806	1689	20	encoding	encode	VERB
fnp-3806	1689	21	a	a	DET
fnp-3806	1689	22	core	core	ADJ
fnp-3806	1689	23	protein	protein	NOUN
fnp-3806	1689	24	of	of	ADP
fnp-3806	1689	25	the	the	DET
fnp-3806	1689	26	paired	pair	VERB
fnp-3806	1689	27	helical	helical	ADJ
fnp-3806	1689	28	filament	filament	NOUN
fnp-3806	1689	29	of	of	ADP
fnp-3806	1689	30	alzheimer	alzheimer	PROPN
fnp-3806	1689	31	disease	disease	PROPN
fnp-3806	1689	32	:	:	PUNCT
fnp-3806	1689	33	identification	identification	NOUN
fnp-3806	1689	34	as	as	ADP
fnp-3806	1689	35	microtubule	microtubule	NOUN
fnp-3806	1689	36	-	-	PUNCT
fnp-3806	1689	37	associated	associate	VERB
fnp-3806	1689	38	protein	protein	NOUN
fnp-3806	1689	39	tau	tau	NOUN
fnp-3806	1689	40	.	.	PUNCT
fnp-3806	1690	1	proc	proc	PROPN
fnp-3806	1690	2	natl	natl	PROPN
fnp-3806	1690	3	acad	acad	PROPN
fnp-3806	1690	4	sci	sci	PROPN
fnp-3806	1690	5	usa	usa	PROPN
fnp-3806	1690	6	1988;85	1988;85	NUM
fnp-3806	1690	7	:	:	PUNCT
fnp-3806	1690	8	4051	4051	NUM
fnp-3806	1690	9	-	-	SYM
fnp-3806	1690	10	4055	4055	NUM
fnp-3806	1690	11	.	.	PUNCT
fnp-3806	1691	1	https://doi.org/10.1073/pnas.85.11.4051	https://doi.org/10.1073/pnas.85.11.4051	PROPN
fnp-3806	1691	2	wischik	wischik	VERB
fnp-3806	1691	3	cm	cm	PROPN
fnp-3806	1691	4	,	,	PUNCT
fnp-3806	1691	5	novak	novak	PROPN
fnp-3806	1691	6	m	m	PROPN
fnp-3806	1691	7	,	,	PUNCT
fnp-3806	1691	8	edwards	edwards	PROPN
fnp-3806	1691	9	pc	pc	PROPN
fnp-3806	1691	10	,	,	PUNCT
fnp-3806	1691	11	et	et	PROPN
fnp-3806	1691	12	al	al	PROPN
fnp-3806	1691	13	.	.	PROPN
fnp-3806	1691	14	structural	structural	ADJ
fnp-3806	1691	15	characterization	characterization	NOUN
fnp-3806	1691	16	of	of	ADP
fnp-3806	1691	17	the	the	DET
fnp-3806	1691	18	core	core	NOUN
fnp-3806	1691	19	of	of	ADP
fnp-3806	1691	20	the	the	DET
fnp-3806	1691	21	paired	pair	VERB
fnp-3806	1691	22	helical	helical	ADJ
fnp-3806	1691	23	filament	filament	NOUN
fnp-3806	1691	24	of	of	ADP
fnp-3806	1691	25	alzheimer	alzheimer	PROPN
fnp-3806	1691	26	disease	disease	PROPN
fnp-3806	1691	27	.	.	PUNCT
fnp-3806	1692	1	proc	proc	PROPN
fnp-3806	1692	2	natl	natl	PROPN
fnp-3806	1692	3	acad	acad	PROPN
fnp-3806	1692	4	sci	sci	PROPN
fnp-3806	1692	5	usa	usa	PROPN
fnp-3806	1692	6	1988;85:4884	1988;85:4884	PROPN
fnp-3806	1692	7	-	-	PUNCT
fnp-3806	1692	8	4888	4888	NUM
fnp-3806	1692	9	.	.	PUNCT
fnp-3806	1693	1	https://doi.org/10.1073/pnas.85.13.4884	https://doi.org/10.1073/pnas.85.13.4884	PROPN
fnp-3806	1693	2	kosik	kosik	PROPN
fnp-3806	1694	1	ks	ks	PROPN
fnp-3806	1694	2	,	,	PUNCT
fnp-3806	1694	3	orecchio	orecchio	PROPN
fnp-3806	1694	4	ld	ld	PROPN
fnp-3806	1694	5	,	,	PUNCT
fnp-3806	1694	6	binder	binder	NOUN
fnp-3806	1694	7	l	l	NOUN
fnp-3806	1694	8	,	,	PUNCT
fnp-3806	1694	9	et	et	PROPN
fnp-3806	1694	10	al	al	PROPN
fnp-3806	1694	11	.	.	PROPN
fnp-3806	1694	12	epitopes	epitope	NOUN
fnp-3806	1694	13	that	that	PRON
fnp-3806	1694	14	span	span	VERB
fnp-3806	1694	15	the	the	DET
fnp-3806	1694	16	tau	tau	PROPN
fnp-3806	1694	17	molecule	molecule	NOUN
fnp-3806	1694	18	are	be	AUX
fnp-3806	1694	19	shared	share	VERB
fnp-3806	1694	20	with	with	ADP
fnp-3806	1694	21	paired	pair	VERB
fnp-3806	1694	22	helical	helical	ADJ
fnp-3806	1694	23	filaments	filament	NOUN
fnp-3806	1694	24	.	.	PUNCT
fnp-3806	1695	1	neuron	neuron	PROPN
fnp-3806	1695	2	1988;1:817	1988;1:817	PROPN
fnp-3806	1695	3	-	-	PUNCT
fnp-3806	1695	4	825	825	NUM
fnp-3806	1695	5	.	.	PUNCT
fnp-3806	1696	1	https://doi.org/10.1016/0896-6273(88)90129-8	https://doi.org/10.1016/0896-6273(88)90129-8	NOUN
fnp-3806	1696	2	delacourte	delacourte	NOUN
fnp-3806	1696	3	a	a	X
fnp-3806	1696	4	,	,	PUNCT
fnp-3806	1696	5	buée	buée	NOUN
fnp-3806	1696	6	l.	l.	PROPN
fnp-3806	1696	7	normal	normal	ADJ
fnp-3806	1696	8	and	and	CCONJ
fnp-3806	1696	9	pathological	pathological	ADJ
fnp-3806	1696	10	tau	tau	NOUN
fnp-3806	1696	11	proteins	protein	NOUN
fnp-3806	1696	12	as	as	ADP
fnp-3806	1696	13	factors	factor	NOUN
fnp-3806	1696	14	of	of	ADP
fnp-3806	1696	15	microtubule	microtubule	NOUN
fnp-3806	1696	16	assembly	assembly	NOUN
fnp-3806	1696	17	.	.	PUNCT
fnp-3806	1697	1	int	int	PROPN
fnp-3806	1697	2	rev	rev	PROPN
fnp-3806	1697	3	cytol	cytol	PROPN
fnp-3806	1697	4	1997;171:167	1997;171:167	NUM
fnp-3806	1697	5	-	-	SYM
fnp-3806	1697	6	224	224	NUM
fnp-3806	1697	7	.	.	PUNCT
fnp-3806	1698	1	https://doi.org/10.1016/s0074-7696(08)62588-7	https://doi.org/10.1016/s0074-7696(08)62588-7	PROPN
fnp-3806	1698	2	buée	buée	NOUN
fnp-3806	1698	3	l	l	PROPN
fnp-3806	1698	4	,	,	PUNCT
fnp-3806	1698	5	bussière	bussière	PROPN
fnp-3806	1698	6	t	t	PROPN
fnp-3806	1698	7	,	,	PUNCT
fnp-3806	1698	8	buée	buée	NOUN
fnp-3806	1698	9	-	-	PUNCT
fnp-3806	1698	10	scherrer	scherrer	NOUN
fnp-3806	1698	11	v	v	NOUN
fnp-3806	1698	12	,	,	PUNCT
fnp-3806	1698	13	et	et	PROPN
fnp-3806	1698	14	al	al	PROPN
fnp-3806	1698	15	.	.	PUNCT
fnp-3806	1699	1	tau	tau	PROPN
fnp-3806	1699	2	protein	protein	NOUN
fnp-3806	1699	3	isoforms	isoform	NOUN
fnp-3806	1699	4	,	,	PUNCT
fnp-3806	1699	5	phosphorylation	phosphorylation	NOUN
fnp-3806	1699	6	and	and	CCONJ
fnp-3806	1699	7	role	role	NOUN
fnp-3806	1699	8	in	in	ADP
fnp-3806	1699	9	neurodegenerative	neurodegenerative	ADJ
fnp-3806	1699	10	disorders	disorder	NOUN
fnp-3806	1699	11	.	.	PUNCT
fnp-3806	1700	1	brain	brain	NOUN
fnp-3806	1700	2	res	re	NOUN
fnp-3806	1700	3	brain	brain	NOUN
fnp-3806	1700	4	res	re	NOUN
fnp-3806	1700	5	rev	rev	X
fnp-3806	1700	6	2000	2000	NUM
fnp-3806	1700	7	;	;	PUNCT
fnp-3806	1700	8	33:95	33:95	NUM
fnp-3806	1700	9	-	-	SYM
fnp-3806	1700	10	130	130	NUM
fnp-3806	1700	11	.	.	PUNCT
fnp-3806	1701	1	https://doi.org/10.1016/s0165-0173(00)00019-9	https://doi.org/10.1016/s0165-0173(00)00019-9	PROPN
fnp-3806	1701	2	iqbal	iqbal	PROPN
fnp-3806	1701	3	k	k	PROPN
fnp-3806	1701	4	,	,	PUNCT
fnp-3806	1701	5	grundke	grundke	ADJ
fnp-3806	1701	6	-	-	PUNCT
fnp-3806	1701	7	iqbal	iqbal	NOUN
fnp-3806	1701	8	i.	i.	NOUN
fnp-3806	1701	9	discoveries	discovery	NOUN
fnp-3806	1701	10	of	of	ADP
fnp-3806	1701	11	tau	tau	PROPN
fnp-3806	1701	12	,	,	PUNCT
fnp-3806	1701	13	abnormally	abnormally	ADV
fnp-3806	1701	14	hyperphosphorylated	hyperphosphorylate	VERB
fnp-3806	1701	15	tau	tau	PROPN
fnp-3806	1701	16	and	and	CCONJ
fnp-3806	1701	17	others	other	NOUN
fnp-3806	1701	18	of	of	ADP
fnp-3806	1701	19	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1701	20	degeneration	degeneration	NOUN
fnp-3806	1701	21	:	:	PUNCT
fnp-3806	1701	22	a	a	DET
fnp-3806	1701	23	personal	personal	ADJ
fnp-3806	1701	24	historical	historical	ADJ
fnp-3806	1701	25	perspective	perspective	NOUN
fnp-3806	1701	26	.	.	PUNCT
fnp-3806	1702	1	j	j	PROPN
fnp-3806	1702	2	alzheimers	alzheimers	PROPN
fnp-3806	1702	3	dis	dis	PROPN
fnp-3806	1702	4	2006;9:219	2006;9:219	NUM
fnp-3806	1702	5	-	-	SYM
fnp-3806	1702	6	242	242	NUM
fnp-3806	1702	7	.	.	PUNCT
fnp-3806	1703	1	https://doi.org/10.3233/jad-2006-9s325	https://doi.org/10.3233/jad-2006-9s325	PROPN
fnp-3806	1703	2	mandelkow	mandelkow	PROPN
fnp-3806	1703	3	em	em	PRON
fnp-3806	1703	4	,	,	PUNCT
fnp-3806	1703	5	mandelkow	mandelkow	PROPN
fnp-3806	1703	6	e.	e.	PROPN
fnp-3806	1703	7	biochemistry	biochemistry	PROPN
fnp-3806	1703	8	and	and	CCONJ
fnp-3806	1703	9	cell	cell	NOUN
fnp-3806	1703	10	biology	biology	NOUN
fnp-3806	1703	11	of	of	ADP
fnp-3806	1703	12	tau	tau	PROPN
fnp-3806	1703	13	protein	protein	NOUN
fnp-3806	1703	14	in	in	ADP
fnp-3806	1703	15	neurofbrillary	neurofbrillary	ADJ
fnp-3806	1703	16	degeneration	degeneration	NOUN
fnp-3806	1703	17	.	.	PUNCT
fnp-3806	1704	1	cold	cold	ADJ
fnp-3806	1704	2	spring	spring	NOUN
fnp-3806	1704	3	harb	harb	PROPN
fnp-3806	1704	4	perspect	perspect	VERB
fnp-3806	1704	5	med	med	PROPN
fnp-3806	1704	6	2012;2	2012;2	NUM
fnp-3806	1704	7	:	:	PUNCT
fnp-3806	1704	8	a006247	a006247	NOUN
fnp-3806	1704	9	.	.	PUNCT
fnp-3806	1705	1	https://doi.org/10.1101/cshperspect.a006247	https://doi.org/10.1101/cshperspect.a006247	PROPN
fnp-3806	1705	2	spillantini	spillantini	PROPN
fnp-3806	1705	3	mg	mg	PROPN
fnp-3806	1705	4	,	,	PUNCT
fnp-3806	1705	5	goedert	goedert	PROPN
fnp-3806	1705	6	m.	m.	PROPN
fnp-3806	1705	7	tau	tau	PROPN
fnp-3806	1705	8	pathology	pathology	NOUN
fnp-3806	1705	9	and	and	CCONJ
fnp-3806	1705	10	neurodegeneration	neurodegeneration	NOUN
fnp-3806	1705	11	.	.	PUNCT
fnp-3806	1706	1	lancet	lancet	PROPN
fnp-3806	1706	2	neurol	neurol	PROPN
fnp-3806	1706	3	2013;12	2013;12	PROPN
fnp-3806	1706	4	:	:	PUNCT
fnp-3806	1706	5	609	609	NUM
fnp-3806	1706	6	-	-	SYM
fnp-3806	1706	7	622	622	NUM
fnp-3806	1706	8	.	.	PUNCT
fnp-3806	1707	1	https://doi.org/10.1016/s1474-4422(13)70090-5	https://doi.org/10.1016/s1474-4422(13)70090-5	PROPN
fnp-3806	1707	2	arendt	arendt	PROPN
fnp-3806	1707	3	t	t	PROPN
fnp-3806	1707	4	,	,	PUNCT
fnp-3806	1707	5	stieler	stieler	PROPN
fnp-3806	1707	6	jt	jt	PROPN
fnp-3806	1707	7	,	,	PUNCT
fnp-3806	1707	8	holzer	holzer	PROPN
fnp-3806	1707	9	m.	m.	PROPN
fnp-3806	1707	10	tau	tau	PROPN
fnp-3806	1707	11	and	and	CCONJ
fnp-3806	1707	12	tauopathies	tauopathie	NOUN
fnp-3806	1707	13	.	.	PUNCT
fnp-3806	1708	1	brain	brain	NOUN
fnp-3806	1708	2	res	re	NOUN
fnp-3806	1708	3	bull	bull	PROPN
fnp-3806	1708	4	2016	2016	NUM
fnp-3806	1708	5	,	,	PUNCT
fnp-3806	1708	6	26	26	NUM
fnp-3806	1708	7	:	:	SYM
fnp-3806	1708	8	238	238	NUM
fnp-3806	1708	9	-	-	SYM
fnp-3806	1708	10	292	292	NUM
fnp-3806	1708	11	.	.	PUNCT
fnp-3806	1709	1	https://doi.org/10.1016/j.brainresbull.2016.08.018	https://doi.org/10.1016/j.brainresbull.2016.08.018	NOUN
fnp-3806	1709	2	iqbal	iqbal	PROPN
fnp-3806	1709	3	k	k	PROPN
fnp-3806	1709	4	,	,	PUNCT
fnp-3806	1709	5	liu	liu	PROPN
fnp-3806	1709	6	f	f	PROPN
fnp-3806	1709	7	,	,	PUNCT
fnp-3806	1709	8	gong	gong	PROPN
fnp-3806	1709	9	cx	cx	PROPN
fnp-3806	1709	10	.	.	PUNCT
fnp-3806	1710	1	tau	tau	PROPN
fnp-3806	1710	2	and	and	CCONJ
fnp-3806	1710	3	neurodegenerative	neurodegenerative	ADJ
fnp-3806	1710	4	disease	disease	NOUN
fnp-3806	1710	5	:	:	PUNCT
fnp-3806	1710	6	the	the	DET
fnp-3806	1710	7	story	story	NOUN
fnp-3806	1710	8	so	so	ADV
fnp-3806	1710	9	far	far	ADV
fnp-3806	1710	10	.	.	PUNCT
fnp-3806	1711	1	nat	nat	PROPN
fnp-3806	1711	2	rev	rev	VERB
fnp-3806	1711	3	neurol	neurol	PROPN
fnp-3806	1711	4	2016;12:15	2016;12:15	NUM
fnp-3806	1711	5	-	-	SYM
fnp-3806	1711	6	27	27	NUM
fnp-3806	1711	7	.	.	PUNCT
fnp-3806	1712	1	https://doi.org/10.1038/nrneurol.2015.225	https://doi.org/10.1038/nrneurol.2015.225	PROPN
fnp-3806	1712	2	goedert	goedert	VERB
fnp-3806	1712	3	m	m	PROPN
fnp-3806	1712	4	,	,	PUNCT
fnp-3806	1712	5	spillantini	spillantini	PROPN
fnp-3806	1712	6	mg	mg	PROPN
fnp-3806	1712	7	.	.	PUNCT
fnp-3806	1713	1	ordered	order	VERB
fnp-3806	1713	2	assembly	assembly	NOUN
fnp-3806	1713	3	of	of	ADP
fnp-3806	1713	4	tau	tau	PROPN
fnp-3806	1713	5	protein	protein	NOUN
fnp-3806	1713	6	and	and	CCONJ
fnp-3806	1713	7	neurodegeneration	neurodegeneration	NOUN
fnp-3806	1713	8	.	.	PUNCT
fnp-3806	1714	1	adv	adv	PROPN
fnp-3806	1714	2	exp	exp	NOUN
fnp-3806	1714	3	med	med	ADJ
fnp-3806	1714	4	biol	biol	NOUN
fnp-3806	1714	5	2019;1184:3	2019;1184:3	NUM
fnp-3806	1714	6	-	-	SYM
fnp-3806	1714	7	21	21	NUM
fnp-3806	1714	8	.	.	PUNCT
fnp-3806	1715	1	https://doi.org/10.1007/978-981-32-9358-8_1	https://doi.org/10.1007/978-981-32-9358-8_1	PROPN
fnp-3806	1715	2	goedert	goedert	PROPN
fnp-3806	1715	3	m	m	PROPN
fnp-3806	1715	4	,	,	PUNCT
fnp-3806	1715	5	spillantini	spillantini	PROPN
fnp-3806	1715	6	mg	mg	PROPN
fnp-3806	1715	7	,	,	PUNCT
fnp-3806	1715	8	cairns	cairns	PROPN
fnp-3806	1715	9	nj	nj	PROPN
fnp-3806	1715	10	,	,	PUNCT
fnp-3806	1715	11	et	et	PROPN
fnp-3806	1715	12	al	al	PROPN
fnp-3806	1715	13	.	.	PUNCT
fnp-3806	1716	1	tau	tau	PROPN
fnp-3806	1716	2	proteins	protein	NOUN
fnp-3806	1716	3	in	in	ADP
fnp-3806	1716	4	alzheimer	alzheimer	PROPN
fnp-3806	1716	5	paired	pair	VERB
fnp-3806	1716	6	helical	helical	ADJ
fnp-3806	1716	7	filaments	filament	NOUN
fnp-3806	1716	8	:	:	PUNCT
fnp-3806	1716	9	abnormal	abnormal	ADJ
fnp-3806	1716	10	phosphorylation	phosphorylation	NOUN
fnp-3806	1716	11	of	of	ADP
fnp-3806	1716	12	all	all	DET
fnp-3806	1716	13	six	six	NUM
fnp-3806	1716	14	brain	brain	NOUN
fnp-3806	1716	15	isoforms	isoform	NOUN
fnp-3806	1716	16	.	.	PUNCT
fnp-3806	1717	1	neuron	neuron	PROPN
fnp-3806	1717	2	1992	1992	NUM
fnp-3806	1717	3	;	;	PUNCT
fnp-3806	1717	4	8	8	NUM
fnp-3806	1717	5	:	:	SYM
fnp-3806	1717	6	159	159	NUM
fnp-3806	1717	7	-	-	SYM
fnp-3806	1717	8	168	168	NUM
fnp-3806	1717	9	.	.	PUNCT
fnp-3806	1718	1	https://doi.org/10.1016/0896-6273(92)90117-v	https://doi.org/10.1016/0896-6273(92)90117-v	ADJ
fnp-3806	1718	2	delacourte	delacourte	PROPN
fnp-3806	1718	3	a	a	X
fnp-3806	1718	4	,	,	PUNCT
fnp-3806	1718	5	david	david	PROPN
fnp-3806	1718	6	jp	jp	PROPN
fnp-3806	1718	7	,	,	PUNCT
fnp-3806	1718	8	sergeant	sergeant	PROPN
fnp-3806	1718	9	n	n	CCONJ
fnp-3806	1718	10	,	,	PUNCT
fnp-3806	1718	11	et	et	PROPN
fnp-3806	1718	12	al	al	PROPN
fnp-3806	1718	13	.	.	PUNCT
fnp-3806	1719	1	the	the	DET
fnp-3806	1719	2	biochemical	biochemical	ADJ
fnp-3806	1719	3	pathway	pathway	NOUN
fnp-3806	1719	4	of	of	ADP
fnp-3806	1719	5	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1719	6	degeneration	degeneration	NOUN
fnp-3806	1719	7	in	in	ADP
fnp-3806	1719	8	aging	aging	NOUN
fnp-3806	1719	9	and	and	CCONJ
fnp-3806	1719	10	alzheimer	alzheimer	PROPN
fnp-3806	1719	11	’s	’s	PART
fnp-3806	1719	12	disease	disease	NOUN
fnp-3806	1719	13	.	.	PUNCT
fnp-3806	1720	1	neurology	neurology	NOUN
fnp-3806	1720	2	1999;52	1999;52	NUM
fnp-3806	1720	3	:	:	PUNCT
fnp-3806	1720	4	1158	1158	NUM
fnp-3806	1720	5	-	-	SYM
fnp-3806	1720	6	1165	1165	NUM
fnp-3806	1720	7	.	.	PUNCT
fnp-3806	1721	1	https://doi.org/10.1212/wnl.52.6.1158	https://doi.org/10.1212/wnl.52.6.1158	PROPN
fnp-3806	1721	2	novak	novak	PROPN
fnp-3806	1721	3	m	m	PROPN
fnp-3806	1721	4	,	,	PUNCT
fnp-3806	1721	5	kabat	kabat	PROPN
fnp-3806	1721	6	j	j	PROPN
fnp-3806	1721	7	,	,	PUNCT
fnp-3806	1721	8	wischik	wischik	VERB
fnp-3806	1721	9	cm	cm	NOUN
fnp-3806	1721	10	.	.	PUNCT
fnp-3806	1722	1	molecular	molecular	ADJ
fnp-3806	1722	2	characterization	characterization	NOUN
fnp-3806	1722	3	of	of	ADP
fnp-3806	1722	4	the	the	DET
fnp-3806	1722	5	minimal	minimal	ADJ
fnp-3806	1722	6	protease	protease	NOUN
fnp-3806	1722	7	resistant	resistant	ADJ
fnp-3806	1722	8	tau	tau	PROPN
fnp-3806	1722	9	unit	unit	NOUN
fnp-3806	1722	10	of	of	ADP
fnp-3806	1722	11	the	the	DET
fnp-3806	1722	12	alzheimer	alzheimer	PROPN
fnp-3806	1722	13	's	's	PART
fnp-3806	1722	14	disease	disease	NOUN
fnp-3806	1722	15	paired	pair	VERB
fnp-3806	1722	16	helical	helical	ADJ
fnp-3806	1722	17	filament	filament	NOUN
fnp-3806	1722	18	.	.	PUNCT
fnp-3806	1723	1	embo	embo	PROPN
fnp-3806	1723	2	j	j	PROPN
fnp-3806	1723	3	1993;12:365	1993;12:365	NUM
fnp-3806	1723	4	-	-	SYM
fnp-3806	1723	5	370	370	NUM
fnp-3806	1723	6	.	.	PUNCT
fnp-3806	1724	1	https://doi.org/10.1002/j.1460-2075.1993.tb05665.x	https://doi.org/10.1002/j.1460-2075.1993.tb05665.x	PROPN
fnp-3806	1724	2	jicha	jicha	PROPN
fnp-3806	1724	3	ga	ga	PROPN
fnp-3806	1724	4	,	,	PUNCT
fnp-3806	1724	5	berenfeld	berenfeld	PROPN
fnp-3806	1724	6	b	b	PROPN
fnp-3806	1724	7	,	,	PUNCT
fnp-3806	1724	8	davies	davy	NOUN
fnp-3806	1724	9	p.	p.	NOUN
fnp-3806	1724	10	sequence	sequence	NOUN
fnp-3806	1724	11	requirements	requirement	NOUN
fnp-3806	1724	12	for	for	ADP
fnp-3806	1724	13	formation	formation	NOUN
fnp-3806	1724	14	of	of	ADP
fnp-3806	1724	15	conformational	conformational	ADJ
fnp-3806	1724	16	variants	variant	NOUN
fnp-3806	1724	17	of	of	ADP
fnp-3806	1724	18	tau	tau	PROPN
fnp-3806	1724	19	similar	similar	ADJ
fnp-3806	1724	20	to	to	ADP
fnp-3806	1724	21	those	those	PRON
fnp-3806	1724	22	found	find	VERB
fnp-3806	1724	23	in	in	ADP
fnp-3806	1724	24	alzheimer	alzheimer	PROPN
fnp-3806	1724	25	's	's	PART
fnp-3806	1724	26	disease	disease	NOUN
fnp-3806	1724	27	.	.	PUNCT
fnp-3806	1725	1	j	j	PROPN
fnp-3806	1725	2	neurosci	neurosci	PROPN
fnp-3806	1725	3	res	re	VERB
fnp-3806	1725	4	1999	1999	NUM
fnp-3806	1725	5	;	;	PUNCT
fnp-3806	1725	6	55:713	55:713	NUM
fnp-3806	1725	7	-	-	SYM
fnp-3806	1725	8	723	723	NUM
fnp-3806	1725	9	.	.	PUNCT
fnp-3806	1726	1	https://doi.org/10.1002/(sici)1097-4547(19990315)55:6<713::aid-jnr6>3.0.co;2-g	https://doi.org/10.1002/(sici)1097-4547(19990315)55:6<713::aid-jnr6>3.0.co;2-g	DET
fnp-3806	1726	2	weaver	weaver	NOUN
fnp-3806	1726	3	cl	cl	NOUN
fnp-3806	1726	4	,	,	PUNCT
fnp-3806	1726	5	espinoza	espinoza	PROPN
fnp-3806	1726	6	m	m	PROPN
fnp-3806	1726	7	,	,	PUNCT
fnp-3806	1726	8	kress	kress	PROPN
fnp-3806	1726	9	y	y	PROPN
fnp-3806	1726	10	,	,	PUNCT
fnp-3806	1726	11	et	et	PROPN
fnp-3806	1726	12	al	al	PROPN
fnp-3806	1726	13	.	.	PUNCT
fnp-3806	1726	14	conformational	conformational	ADJ
fnp-3806	1726	15	change	change	NOUN
fnp-3806	1726	16	as	as	ADP
fnp-3806	1726	17	one	one	NUM
fnp-3806	1726	18	of	of	ADP
fnp-3806	1726	19	the	the	DET
fnp-3806	1726	20	earliest	early	ADJ
fnp-3806	1726	21	alterations	alteration	NOUN
fnp-3806	1726	22	of	of	ADP
fnp-3806	1726	23	tau	tau	PROPN
fnp-3806	1726	24	in	in	ADP
fnp-3806	1726	25	alzheimer	alzheimer	PROPN
fnp-3806	1726	26	's	's	PART
fnp-3806	1726	27	disease	disease	NOUN
fnp-3806	1726	28	.	.	PUNCT
fnp-3806	1727	1	neurobiol	neurobiol	PROPN
fnp-3806	1727	2	aging	age	VERB
fnp-3806	1727	3	2000;21:719	2000;21:719	NOUN
fnp-3806	1727	4	-	-	SYM
fnp-3806	1727	5	727	727	NUM
fnp-3806	1727	6	.	.	PUNCT
fnp-3806	1728	1	https://doi.org/10.1016/s0197-4580(00)00157-3	https://doi.org/10.1016/s0197-4580(00)00157-3	PROPN
fnp-3806	1728	2	gamblin	gamblin	PROPN
fnp-3806	1728	3	tc	tc	PROPN
fnp-3806	1728	4	,	,	PUNCT
fnp-3806	1728	5	chen	chen	PROPN
fnp-3806	1728	6	f	f	PROPN
fnp-3806	1728	7	,	,	PUNCT
fnp-3806	1728	8	zambrano	zambrano	PROPN
fnp-3806	1728	9	a	a	PROPN
fnp-3806	1728	10	,	,	PUNCT
fnp-3806	1728	11	et	et	PROPN
fnp-3806	1728	12	al	al	PROPN
fnp-3806	1728	13	.	.	PUNCT
fnp-3806	1729	1	caspase	caspase	PROPN
fnp-3806	1729	2	cleavage	cleavage	NOUN
fnp-3806	1729	3	of	of	ADP
fnp-3806	1729	4	tau	tau	PROPN
fnp-3806	1729	5	:	:	PUNCT
fnp-3806	1729	6	linking	link	VERB
fnp-3806	1729	7	amyloid	amyloid	NOUN
fnp-3806	1729	8	and	and	CCONJ
fnp-3806	1729	9	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1729	10	tangles	tangle	NOUN
fnp-3806	1729	11	in	in	ADP
fnp-3806	1729	12	alzheimer	alzheimer	PROPN
fnp-3806	1729	13	's	's	PART
fnp-3806	1729	14	disease	disease	NOUN
fnp-3806	1729	15	.	.	PUNCT
fnp-3806	1730	1	proc	proc	PROPN
fnp-3806	1730	2	natl	natl	PROPN
fnp-3806	1730	3	acad	acad	PROPN
fnp-3806	1730	4	sci	sci	PROPN
fnp-3806	1730	5	usa	usa	PROPN
fnp-3806	1730	6	2003;100:10032	2003;100:10032	NUM
fnp-3806	1730	7	-	-	SYM
fnp-3806	1730	8	10037	10037	NUM
fnp-3806	1730	9	.	.	PUNCT
fnp-3806	1731	1	https://doi.org/10.1073/pnas.1630428100	https://doi.org/10.1073/pnas.1630428100	NOUN
fnp-3806	1731	2	garcía	garcía	PROPN
fnp-3806	1731	3	-	-	PUNCT
fnp-3806	1731	4	sierra	sierra	PROPN
fnp-3806	1731	5	f	f	PROPN
fnp-3806	1731	6	,	,	PUNCT
fnp-3806	1731	7	ghoshal	ghoshal	NOUN
fnp-3806	1731	8	n	n	CCONJ
fnp-3806	1731	9	,	,	PUNCT
fnp-3806	1731	10	quinn	quinn	PROPN
fnp-3806	1731	11	b	b	PROPN
fnp-3806	1731	12	,	,	PUNCT
fnp-3806	1731	13	et	et	PROPN
fnp-3806	1731	14	al	al	PROPN
fnp-3806	1731	15	.	.	PUNCT
fnp-3806	1732	1	conformational	conformational	ADJ
fnp-3806	1732	2	changes	change	NOUN
fnp-3806	1732	3	and	and	CCONJ
fnp-3806	1732	4	truncation	truncation	NOUN
fnp-3806	1732	5	of	of	ADP
fnp-3806	1732	6	tau	tau	PROPN
fnp-3806	1732	7	protein	protein	NOUN
fnp-3806	1732	8	during	during	ADP
fnp-3806	1732	9	tangle	tangle	NOUN
fnp-3806	1732	10	evolution	evolution	NOUN
fnp-3806	1732	11	in	in	ADP
fnp-3806	1732	12	alzheimer	alzheimer	PROPN
fnp-3806	1732	13	's	's	PART
fnp-3806	1732	14	disease	disease	NOUN
fnp-3806	1732	15	.	.	PUNCT
fnp-3806	1733	1	j	j	PROPN
fnp-3806	1733	2	alzheimers	alzheimers	PROPN
fnp-3806	1733	3	dis	dis	PROPN
fnp-3806	1733	4	2003;5:65	2003;5:65	AUX
fnp-3806	1733	5	-	-	PUNCT
fnp-3806	1733	6	77	77	NUM
fnp-3806	1733	7	.	.	PUNCT
fnp-3806	1734	1	https://doi.org/10.3233/jad-2003-5201	https://doi.org/10.3233/jad-2003-5201	VERB
fnp-3806	1734	2	rissman	rissman	PROPN
fnp-3806	1734	3	ra	ra	PROPN
fnp-3806	1734	4	,	,	PUNCT
fnp-3806	1734	5	poon	poon	NOUN
fnp-3806	1734	6	ww	ww	PROPN
fnp-3806	1734	7	,	,	PUNCT
fnp-3806	1734	8	blurton	blurton	PROPN
fnp-3806	1734	9	-	-	PUNCT
fnp-3806	1734	10	jones	jones	PROPN
fnp-3806	1734	11	m	m	PROPN
fnp-3806	1734	12	,	,	PUNCT
fnp-3806	1734	13	et	et	PROPN
fnp-3806	1734	14	al	al	PROPN
fnp-3806	1734	15	.	.	PUNCT
fnp-3806	1735	1	caspase	caspase	NOUN
fnp-3806	1735	2	-	-	PUNCT
fnp-3806	1735	3	cleavage	cleavage	NOUN
fnp-3806	1735	4	of	of	ADP
fnp-3806	1735	5	tau	tau	PROPN
fnp-3806	1735	6	is	be	AUX
fnp-3806	1735	7	an	an	DET
fnp-3806	1735	8	early	early	ADJ
fnp-3806	1735	9	event	event	NOUN
fnp-3806	1735	10	in	in	ADP
fnp-3806	1735	11	alzheimer	alzheimer	PROPN
fnp-3806	1735	12	disease	disease	PROPN
fnp-3806	1735	13	tangle	tangle	NOUN
fnp-3806	1735	14	pathology	pathology	NOUN
fnp-3806	1735	15	.	.	PUNCT
fnp-3806	1736	1	j	j	PROPN
fnp-3806	1736	2	clin	clin	PROPN
fnp-3806	1736	3	invest	invest	VERB
fnp-3806	1736	4	2004;114:121	2004;114:121	NUM
fnp-3806	1736	5	-	-	SYM
fnp-3806	1736	6	130	130	NUM
fnp-3806	1736	7	.	.	PUNCT
fnp-3806	1737	1	https://doi.org/10.1172/jci20640	https://doi.org/10.1172/jci20640	ADJ
fnp-3806	1737	2	hyman	hyman	PROPN
fnp-3806	1737	3	bt	bt	PROPN
fnp-3806	1737	4	,	,	PUNCT
fnp-3806	1737	5	augustinack	augustinack	PROPN
fnp-3806	1737	6	jc	jc	PROPN
fnp-3806	1737	7	,	,	PUNCT
fnp-3806	1737	8	ingelsson	ingelsson	NOUN
fnp-3806	1737	9	m.	m.	NOUN
fnp-3806	1737	10	transcriptional	transcriptional	NOUN
fnp-3806	1737	11	and	and	CCONJ
fnp-3806	1737	12	conformational	conformational	ADJ
fnp-3806	1737	13	changes	change	NOUN
fnp-3806	1737	14	of	of	ADP
fnp-3806	1737	15	the	the	DET
fnp-3806	1737	16	tau	tau	PROPN
fnp-3806	1737	17	molecule	molecule	NOUN
fnp-3806	1737	18	in	in	ADP
fnp-3806	1737	19	alzheimer	alzheimer	PROPN
fnp-3806	1737	20	's	's	PART
fnp-3806	1737	21	disease	disease	NOUN
fnp-3806	1737	22	.	.	PUNCT
fnp-3806	1738	1	biochim	biochim	PROPN
fnp-3806	1738	2	biophys	biophy	NOUN
fnp-3806	1738	3	acta	acta	PROPN
fnp-3806	1738	4	2005;1739:150	2005;1739:150	PROPN
fnp-3806	1738	5	-	-	SYM
fnp-3806	1738	6	157	157	NUM
fnp-3806	1738	7	.	.	PUNCT
fnp-3806	1739	1	https://doi.org/10.1016/j.bbadis.2004.06.015	https://doi.org/10.1016/j.bbadis.2004.06.015	PROPN
fnp-3806	1739	2	andreadis	andreadis	ADJ
fnp-3806	1739	3	a.	a.	NOUN
fnp-3806	1739	4	tau	tau	PROPN
fnp-3806	1739	5	gene	gene	NOUN
fnp-3806	1739	6	alternative	alternative	ADJ
fnp-3806	1739	7	splicing	splicing	NOUN
fnp-3806	1739	8	:	:	PUNCT
fnp-3806	1740	1	expression	expression	NOUN
fnp-3806	1740	2	patterns	pattern	NOUN
fnp-3806	1740	3	,	,	PUNCT
fnp-3806	1740	4	regulation	regulation	NOUN
fnp-3806	1740	5	and	and	CCONJ
fnp-3806	1740	6	modulation	modulation	NOUN
fnp-3806	1740	7	of	of	ADP
fnp-3806	1740	8	function	function	NOUN
fnp-3806	1740	9	in	in	ADP
fnp-3806	1740	10	normal	normal	ADJ
fnp-3806	1740	11	brain	brain	NOUN
fnp-3806	1740	12	and	and	CCONJ
fnp-3806	1740	13	neurodegenerative	neurodegenerative	ADJ
fnp-3806	1740	14	diseases	disease	NOUN
fnp-3806	1740	15	.	.	PUNCT
fnp-3806	1741	1	biochim	biochim	PROPN
fnp-3806	1741	2	biophys	biophy	NOUN
fnp-3806	1741	3	acta	acta	PROPN
fnp-3806	1741	4	2005;1739:91	2005;1739:91	NUM
fnp-3806	1741	5	-	-	SYM
fnp-3806	1741	6	103	103	NUM
fnp-3806	1741	7	.	.	PUNCT
fnp-3806	1742	1	https://doi.org/10.1016/j.bbadis.2004.08.010	https://doi.org/10.1016/j.bbadis.2004.08.010	PROPN
fnp-3806	1742	2	avila	avila	PROPN
fnp-3806	1742	3	j.	j.	PROPN
fnp-3806	1742	4	tau	tau	PROPN
fnp-3806	1742	5	phosphorylation	phosphorylation	NOUN
fnp-3806	1742	6	and	and	CCONJ
fnp-3806	1742	7	aggregation	aggregation	NOUN
fnp-3806	1742	8	in	in	ADP
fnp-3806	1742	9	alzheimer	alzheimer	PROPN
fnp-3806	1742	10	's	's	PART
fnp-3806	1742	11	disease	disease	NOUN
fnp-3806	1742	12	pathology	pathology	PROPN
fnp-3806	1742	13	.	.	PUNCT
fnp-3806	1743	1	febs	febs	VERB
fnp-3806	1743	2	lett	lett	PROPN
fnp-3806	1743	3	2006;580:2922	2006;580:2922	PROPN
fnp-3806	1743	4	-	-	NUM
fnp-3806	1743	5	2927	2927	NUM
fnp-3806	1743	6	.	.	PUNCT
fnp-3806	1744	1	https://doi.org/10.1016/j.febslet.2006.02.067	https://doi.org/10.1016/j.febslet.2006.02.067	NOUN
fnp-3806	1744	2	zilka	zilka	NOUN
fnp-3806	1744	3	n	n	CCONJ
fnp-3806	1744	4	,	,	PUNCT
fnp-3806	1744	5	filipcik	filipcik	VERB
fnp-3806	1744	6	p	p	NOUN
fnp-3806	1744	7	,	,	PUNCT
fnp-3806	1744	8	koson	koson	PROPN
fnp-3806	1744	9	p	p	PROPN
fnp-3806	1744	10	,	,	PUNCT
fnp-3806	1744	11	et	et	PROPN
fnp-3806	1744	12	al	al	PROPN
fnp-3806	1744	13	.	.	PROPN
fnp-3806	1744	14	truncated	truncate	VERB
fnp-3806	1744	15	tau	tau	PROPN
fnp-3806	1744	16	from	from	ADP
fnp-3806	1744	17	sporadic	sporadic	ADJ
fnp-3806	1744	18	alzheimer	alzheimer	PROPN
fnp-3806	1744	19	's	's	PART
fnp-3806	1744	20	disease	disease	NOUN
fnp-3806	1744	21	suffices	suffice	VERB
fnp-3806	1744	22	to	to	PART
fnp-3806	1744	23	drive	drive	VERB
fnp-3806	1744	24	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1744	25	degeneration	degeneration	NOUN
fnp-3806	1744	26	in	in	ADP
fnp-3806	1744	27	vivo	vivo	NOUN
fnp-3806	1744	28	.	.	PUNCT
fnp-3806	1745	1	febs	febs	PROPN
fnp-3806	1745	2	lett	lett	PROPN
fnp-3806	1745	3	2006;580:3582	2006;580:3582	NUM
fnp-3806	1745	4	-	-	SYM
fnp-3806	1745	5	3588	3588	NUM
fnp-3806	1745	6	.	.	PUNCT
fnp-3806	1746	1	https://doi.org/10.1016/j.febslet.2006.05.029	https://doi.org/10.1016/j.febslet.2006.05.029	PROPN
fnp-3806	1746	2	luna	luna	PROPN
fnp-3806	1746	3	-	-	PUNCT
fnp-3806	1746	4	muñoz	muñoz	PROPN
fnp-3806	1746	5	j	j	PROPN
fnp-3806	1746	6	,	,	PUNCT
fnp-3806	1746	7	chávez	chávez	PROPN
fnp-3806	1746	8	-	-	PUNCT
fnp-3806	1746	9	macías	macías	NOUN
fnp-3806	1746	10	l	l	NOUN
fnp-3806	1746	11	,	,	PUNCT
fnp-3806	1746	12	garcía	garcía	NOUN
fnp-3806	1746	13	-	-	PUNCT
fnp-3806	1746	14	sierra	sierra	NOUN
fnp-3806	1746	15	f	f	PROPN
fnp-3806	1746	16	,	,	PUNCT
fnp-3806	1746	17	et	et	PROPN
fnp-3806	1746	18	al	al	PROPN
fnp-3806	1746	19	.	.	PROPN
fnp-3806	1746	20	earliest	early	ADJ
fnp-3806	1746	21	stages	stage	NOUN
fnp-3806	1746	22	of	of	ADP
fnp-3806	1746	23	tau	tau	PROPN
fnp-3806	1746	24	conformational	conformational	ADJ
fnp-3806	1746	25	changes	change	NOUN
fnp-3806	1746	26	are	be	AUX
fnp-3806	1746	27	related	relate	VERB
fnp-3806	1746	28	to	to	ADP
fnp-3806	1746	29	the	the	DET
fnp-3806	1746	30	appearance	appearance	NOUN
fnp-3806	1746	31	of	of	ADP
fnp-3806	1746	32	a	a	DET
fnp-3806	1746	33	sequence	sequence	NOUN
fnp-3806	1746	34	of	of	ADP
fnp-3806	1746	35	specific	specific	ADJ
fnp-3806	1746	36	phospho	phospho	NOUN
fnp-3806	1746	37	-	-	PUNCT
fnp-3806	1746	38	dependent	dependent	ADJ
fnp-3806	1746	39	tau	tau	PROPN
fnp-3806	1746	40	epitopes	epitope	NOUN
fnp-3806	1746	41	in	in	ADP
fnp-3806	1746	42	alzheimer	alzheimer	PROPN
fnp-3806	1746	43	's	's	PART
fnp-3806	1746	44	disease	disease	NOUN
fnp-3806	1746	45	.	.	PUNCT
fnp-3806	1747	1	j	j	PROPN
fnp-3806	1747	2	alzheimers	alzheimers	PROPN
fnp-3806	1747	3	dis	dis	PROPN
fnp-3806	1747	4	2007;12:365	2007;12:365	PROPN
fnp-3806	1747	5	-	-	SYM
fnp-3806	1747	6	375	375	NUM
fnp-3806	1747	7	.	.	PUNCT
fnp-3806	1748	1	https://doi.org/10.3233/jad-2007-12410	https://doi.org/10.3233/jad-2007-12410	PROPN
fnp-3806	1748	2	garcía	garcía	PROPN
fnp-3806	1748	3	-	-	PUNCT
fnp-3806	1748	4	sierra	sierra	PROPN
fnp-3806	1748	5	f	f	PROPN
fnp-3806	1748	6	,	,	PUNCT
fnp-3806	1748	7	mondragón	mondragón	NOUN
fnp-3806	1748	8	-	-	PUNCT
fnp-3806	1748	9	rodríguez	rodríguez	NOUN
fnp-3806	1748	10	s	s	PROPN
fnp-3806	1748	11	,	,	PUNCT
fnp-3806	1748	12	basurto	basurto	PROPN
fnp-3806	1748	13	-	-	PUNCT
fnp-3806	1748	14	islas	islas	PROPN
fnp-3806	1748	15	g.	g.	PROPN
fnp-3806	1748	16	truncation	truncation	NOUN
fnp-3806	1748	17	of	of	ADP
fnp-3806	1748	18	tau	tau	PROPN
fnp-3806	1748	19	protein	protein	NOUN
fnp-3806	1748	20	and	and	CCONJ
fnp-3806	1748	21	its	its	PRON
fnp-3806	1748	22	pathological	pathological	ADJ
fnp-3806	1748	23	significance	significance	NOUN
fnp-3806	1748	24	in	in	ADP
fnp-3806	1748	25	alzheimer	alzheimer	PROPN
fnp-3806	1748	26	's	's	PART
fnp-3806	1748	27	disease	disease	NOUN
fnp-3806	1748	28	.	.	PUNCT
fnp-3806	1749	1	https://doi.org/10.3233/jad-2008-14407	https://doi.org/10.3233/jad-2008-14407	PROPN
fnp-3806	1749	2	mondragón	mondragón	PROPN
fnp-3806	1749	3	-	-	PUNCT
fnp-3806	1749	4	rodríguez	rodríguez	NOUN
fnp-3806	1749	5	s	s	PROPN
fnp-3806	1749	6	,	,	PUNCT
fnp-3806	1749	7	basurto	basurto	PROPN
fnp-3806	1749	8	-	-	PUNCT
fnp-3806	1749	9	islas	islas	PROPN
fnp-3806	1749	10	g	g	PROPN
fnp-3806	1749	11	,	,	PUNCT
fnp-3806	1749	12	santa	santa	NOUN
fnp-3806	1749	13	-	-	PUNCT
fnp-3806	1749	14	maria	maria	PROPN
fnp-3806	1749	15	i	i	PROPN
fnp-3806	1749	16	,	,	PUNCT
fnp-3806	1749	17	et	et	PROPN
fnp-3806	1749	18	al	al	PROPN
fnp-3806	1749	19	.	.	PUNCT
fnp-3806	1749	20	cleavage	cleavage	NOUN
fnp-3806	1749	21	and	and	CCONJ
fnp-3806	1749	22	conformational	conformational	ADJ
fnp-3806	1749	23	changes	change	NOUN
fnp-3806	1749	24	of	of	ADP
fnp-3806	1749	25	tau	tau	PROPN
fnp-3806	1749	26	protein	protein	NOUN
fnp-3806	1749	27	follow	follow	NOUN
fnp-3806	1749	28	phosphorylation	phosphorylation	NOUN
fnp-3806	1749	29	during	during	ADP
fnp-3806	1749	30	alzheimer	alzheimer	PROPN
fnp-3806	1749	31	's	's	PART
fnp-3806	1749	32	disease	disease	NOUN
fnp-3806	1749	33	.	.	PUNCT
fnp-3806	1750	1	int	int	PROPN
fnp-3806	1750	2	j	j	PROPN
fnp-3806	1750	3	exp	exp	NOUN
fnp-3806	1750	4	pathol	pathol	NOUN
fnp-3806	1750	5	2008;89:81	2008;89:81	NUM
fnp-3806	1750	6	-	-	SYM
fnp-3806	1750	7	90	90	NUM
fnp-3806	1750	8	.	.	PUNCT
fnp-3806	1751	1	https://doi.org/10.1111/j.1365-2613.2007.00568.x	https://doi.org/10.1111/j.1365-2613.2007.00568.x	PROPN
fnp-3806	1751	2	martin	martin	PROPN
fnp-3806	1751	3	l	l	PROPN
fnp-3806	1751	4	,	,	PUNCT
fnp-3806	1751	5	latypova	latypova	X
fnp-3806	1751	6	x	x	X
fnp-3806	1751	7	,	,	PUNCT
fnp-3806	1751	8	terro	terro	PROPN
fnp-3806	1751	9	f.	f.	PROPN
fnp-3806	1751	10	post	post	PROPN
fnp-3806	1751	11	-	-	ADJ
fnp-3806	1751	12	translational	translational	ADJ
fnp-3806	1751	13	modifications	modification	NOUN
fnp-3806	1751	14	of	of	ADP
fnp-3806	1751	15	tau	tau	PROPN
fnp-3806	1751	16	protein	protein	NOUN
fnp-3806	1751	17	:	:	PUNCT
fnp-3806	1751	18	implications	implication	NOUN
fnp-3806	1751	19	for	for	ADP
fnp-3806	1751	20	alzheimer	alzheimer	PROPN
fnp-3806	1751	21	's	's	PART
fnp-3806	1751	22	disease	disease	NOUN
fnp-3806	1751	23	.	.	PUNCT
fnp-3806	1752	1	neurochem	neurochem	PROPN
fnp-3806	1752	2	int	int	VERB
fnp-3806	1752	3	2011;58:458	2011;58:458	PROPN
fnp-3806	1752	4	-	-	SYM
fnp-3806	1752	5	471	471	NUM
fnp-3806	1752	6	.	.	PUNCT
fnp-3806	1753	1	https://doi.org/10.1016/j.neuint.2010.12.023	https://doi.org/10.1016/j.neuint.2010.12.023	PROPN
fnp-3806	1753	2	cohen	cohen	PROPN
fnp-3806	1753	3	tj	tj	PROPN
fnp-3806	1753	4	,	,	PUNCT
fnp-3806	1753	5	guo	guo	PROPN
fnp-3806	1753	6	jl	jl	PROPN
fnp-3806	1753	7	,	,	PUNCT
fnp-3806	1753	8	hurtado	hurtado	PROPN
fnp-3806	1753	9	de	de	X
fnp-3806	1753	10	,	,	PUNCT
fnp-3806	1753	11	et	et	PROPN
fnp-3806	1753	12	al	al	PROPN
fnp-3806	1753	13	.	.	PUNCT
fnp-3806	1754	1	the	the	DET
fnp-3806	1754	2	acetylation	acetylation	NOUN
fnp-3806	1754	3	of	of	ADP
fnp-3806	1754	4	tau	tau	PROPN
fnp-3806	1754	5	inhibits	inhibit	VERB
fnp-3806	1754	6	its	its	PRON
fnp-3806	1754	7	function	function	NOUN
fnp-3806	1754	8	and	and	CCONJ
fnp-3806	1754	9	promotes	promote	VERB
fnp-3806	1754	10	pathological	pathological	ADJ
fnp-3806	1754	11	tau	tau	PROPN
fnp-3806	1754	12	aggregation	aggregation	NOUN
fnp-3806	1754	13	.	.	PUNCT
fnp-3806	1755	1	nat	nat	PROPN
fnp-3806	1755	2	commun	commun	PROPN
fnp-3806	1755	3	2011;2:252	2011;2:252	PROPN
fnp-3806	1755	4	.	.	PUNCT
fnp-3806	1756	1	https://doi.org/10.1038/ncomms1255	https://doi.org/10.1038/ncomms1255	PROPN
fnp-3806	1756	2	takashima	takashima	PROPN
fnp-3806	1756	3	a.	a.	NOUN
fnp-3806	1756	4	tauopathies	tauopathie	NOUN
fnp-3806	1756	5	and	and	CCONJ
fnp-3806	1756	6	tau	tau	PROPN
fnp-3806	1756	7	oligomers	oligomer	NOUN
fnp-3806	1756	8	.	.	PUNCT
fnp-3806	1757	1	j	j	PROPN
fnp-3806	1757	2	alzheimers	alzheimers	PROPN
fnp-3806	1757	3	dis	dis	PROPN
fnp-3806	1757	4	2013;37:565	2013;37:565	AUX
fnp-3806	1757	5	-	-	PUNCT
fnp-3806	1757	6	568	568	NUM
fnp-3806	1757	7	.	.	PUNCT
fnp-3806	1758	1	https://doi.org/10.3233/jad-130653	https://doi.org/10.3233/jad-130653	PROPN
fnp-3806	1758	2	hernández	hernández	PROPN
fnp-3806	1758	3	f	f	PROPN
fnp-3806	1758	4	,	,	PUNCT
fnp-3806	1758	5	pérez	pérez	PROPN
fnp-3806	1758	6	m	m	PROPN
fnp-3806	1758	7	,	,	PUNCT
fnp-3806	1758	8	gómez	gómez	NOUN
fnp-3806	1758	9	de	de	X
fnp-3806	1758	10	barreda	barreda	PROPN
fnp-3806	1758	11	e	e	PROPN
fnp-3806	1758	12	et	et	PROPN
fnp-3806	1758	13	al	al	PROPN
fnp-3806	1758	14	.	.	PROPN
fnp-3806	1758	15	tau	tau	PROPN
fnp-3806	1758	16	as	as	ADP
fnp-3806	1758	17	a	a	DET
fnp-3806	1758	18	molecular	molecular	ADJ
fnp-3806	1758	19	marker	marker	NOUN
fnp-3806	1758	20	of	of	ADP
fnp-3806	1758	21	development	development	NOUN
fnp-3806	1758	22	,	,	PUNCT
fnp-3806	1758	23	aging	aging	NOUN
fnp-3806	1758	24	and	and	CCONJ
fnp-3806	1758	25	neurodegenerative	neurodegenerative	ADJ
fnp-3806	1758	26	disorders	disorder	NOUN
fnp-3806	1758	27	.	.	PUNCT
fnp-3806	1759	1	curr	curr	NOUN
fnp-3806	1759	2	aging	age	VERB
fnp-3806	1759	3	sci	sci	PROPN
fnp-3806	1759	4	2008;1:56	2008;1:56	NOUN
fnp-3806	1759	5	-	-	PUNCT
fnp-3806	1759	6	61	61	NUM
fnp-3806	1759	7	.	.	PUNCT
fnp-3806	1760	1	https://doi.org/10.2174/1874609810801010056	https://doi.org/10.2174/1874609810801010056	PROPN
fnp-3806	1760	2	fitzpatrick	fitzpatrick	PROPN
fnp-3806	1760	3	awp	awp	PROPN
fnp-3806	1760	4	,	,	PUNCT
fnp-3806	1760	5	falcon	falcon	PROPN
fnp-3806	1760	6	b	b	PROPN
fnp-3806	1760	7	,	,	PUNCT
fnp-3806	1760	8	he	he	PRON
fnp-3806	1760	9	s	s	PART
fnp-3806	1760	10	,	,	PUNCT
fnp-3806	1760	11	et	et	PROPN
fnp-3806	1760	12	al	al	PROPN
fnp-3806	1760	13	.	.	PUNCT
fnp-3806	1761	1	cryo	cryo	PROPN
fnp-3806	1761	2	-	-	PUNCT
fnp-3806	1761	3	em	em	PRON
fnp-3806	1761	4	structures	structure	NOUN
fnp-3806	1761	5	of	of	ADP
fnp-3806	1761	6	tau	tau	PROPN
fnp-3806	1761	7	filaments	filament	NOUN
fnp-3806	1761	8	from	from	ADP
fnp-3806	1761	9	alzheimer	alzheimer	PROPN
fnp-3806	1761	10	's	's	PART
fnp-3806	1761	11	disease	disease	NOUN
fnp-3806	1761	12	.	.	PUNCT
fnp-3806	1762	1	nature	nature	NOUN
fnp-3806	1762	2	2017	2017	NUM
fnp-3806	1762	3	;	;	PUNCT
fnp-3806	1762	4	547:185	547:185	X
fnp-3806	1762	5	-	-	SYM
fnp-3806	1762	6	190	190	NUM
fnp-3806	1762	7	.	.	PUNCT
fnp-3806	1763	1	https://doi.org/10.1038/nature23002	https://doi.org/10.1038/nature23002	PROPN
fnp-3806	1763	2	ramesh	ramesh	PROPN
fnp-3806	1763	3	m	m	PROPN
fnp-3806	1763	4	,	,	PUNCT
fnp-3806	1763	5	gopinath	gopinath	PROPN
fnp-3806	1763	6	p	p	NOUN
fnp-3806	1763	7	,	,	PUNCT
fnp-3806	1763	8	govindaraju	govindaraju	NOUN
fnp-3806	1763	9	t.	t.	NOUN
fnp-3806	1763	10	role	role	NOUN
fnp-3806	1763	11	of	of	ADP
fnp-3806	1763	12	post	post	ADJ
fnp-3806	1763	13	-	-	ADJ
fnp-3806	1763	14	translational	translational	ADJ
fnp-3806	1763	15	modifications	modification	NOUN
fnp-3806	1763	16	in	in	ADP
fnp-3806	1763	17	alzheimer	alzheimer	PROPN
fnp-3806	1763	18	's	's	PART
fnp-3806	1763	19	disease	disease	NOUN
fnp-3806	1763	20	.	.	PUNCT
fnp-3806	1764	1	chembiochem	chembiochem	PROPN
fnp-3806	1764	2	2020;21:1052	2020;21:1052	NUM
fnp-3806	1764	3	-	-	PUNCT
fnp-3806	1764	4	1079	1079	NUM
fnp-3806	1764	5	.	.	PUNCT
fnp-3806	1765	1	https://doi.org/10.1002/cbic.201900573	https://doi.org/10.1002/cbic.201900573	PROPN
fnp-3806	1765	2	wang	wang	PROPN
fnp-3806	1765	3	d	d	PROPN
fnp-3806	1765	4	,	,	PUNCT
fnp-3806	1765	5	huang	huang	PROPN
fnp-3806	1765	6	x	x	PROPN
fnp-3806	1765	7	,	,	PUNCT
fnp-3806	1765	8	yan	yan	PROPN
fnp-3806	1765	9	l	l	PROPN
fnp-3806	1765	10	,	,	PUNCT
fnp-3806	1765	11	et	et	PROPN
fnp-3806	1765	12	al	al	PROPN
fnp-3806	1765	13	.	.	PUNCT
fnp-3806	1766	1	the	the	DET
fnp-3806	1766	2	structure	structure	NOUN
fnp-3806	1766	3	biology	biology	NOUN
fnp-3806	1766	4	of	of	ADP
fnp-3806	1766	5	tau	tau	PROPN
fnp-3806	1766	6	and	and	CCONJ
fnp-3806	1766	7	clue	clue	NOUN
fnp-3806	1766	8	for	for	ADP
fnp-3806	1766	9	aggregation	aggregation	NOUN
fnp-3806	1766	10	inhibitor	inhibitor	NOUN
fnp-3806	1766	11	design	design	NOUN
fnp-3806	1766	12	.	.	PUNCT
fnp-3806	1767	1	protein	protein	NOUN
fnp-3806	1767	2	j	j	PROPN
fnp-3806	1767	3	2021;40:656	2021;40:656	NUM
fnp-3806	1767	4	-	-	SYM
fnp-3806	1767	5	668	668	NUM
fnp-3806	1767	6	.	.	PUNCT
fnp-3806	1768	1	https://doi.org/10.1007/s10930-021-10017-6	https://doi.org/10.1007/s10930-021-10017-6	NUM
fnp-3806	1768	2	moloney	moloney	PROPN
fnp-3806	1768	3	cm	cm	PROPN
fnp-3806	1768	4	,	,	PUNCT
fnp-3806	1768	5	lowe	lowe	PROPN
fnp-3806	1768	6	vj	vj	PROPN
fnp-3806	1768	7	,	,	PUNCT
fnp-3806	1768	8	murray	murray	VERB
fnp-3806	1768	9	me	i	PRON
fnp-3806	1768	10	.	.	PUNCT
fnp-3806	1769	1	visualization	visualization	NOUN
fnp-3806	1769	2	of	of	ADP
fnp-3806	1769	3	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1769	4	tangle	tangle	NOUN
fnp-3806	1769	5	maturity	maturity	NOUN
fnp-3806	1769	6	in	in	ADP
fnp-3806	1769	7	alzheimer	alzheimer	PROPN
fnp-3806	1769	8	's	's	PART
fnp-3806	1769	9	disease	disease	NOUN
fnp-3806	1769	10	:	:	PUNCT
fnp-3806	1769	11	a	a	DET
fnp-3806	1769	12	clinicopathologic	clinicopathologic	ADJ
fnp-3806	1769	13	perspective	perspective	NOUN
fnp-3806	1769	14	for	for	ADP
fnp-3806	1769	15	biomarker	biomarker	NOUN
fnp-3806	1769	16	research	research	NOUN
fnp-3806	1769	17	.	.	PUNCT
fnp-3806	1770	1	alzheimers	alzheimer	NOUN
fnp-3806	1770	2	dement	dement	PROPN
fnp-3806	1770	3	2021;17:1554	2021;17:1554	PROPN
fnp-3806	1770	4	-	-	SYM
fnp-3806	1770	5	1574	1574	NUM
fnp-3806	1770	6	.	.	PUNCT
fnp-3806	1771	1	https://doi.org/10.1002/alz.12321	https://doi.org/10.1002/alz.12321	PROPN
fnp-3806	1771	2	ferrer	ferrer	PROPN
fnp-3806	1771	3	i	i	PROPN
fnp-3806	1771	4	,	,	PUNCT
fnp-3806	1771	5	lópez	lópez	PROPN
fnp-3806	1771	6	-	-	PUNCT
fnp-3806	1771	7	gonzález	gonzález	PROPN
fnp-3806	1771	8	i	i	PRON
fnp-3806	1771	9	,	,	PUNCT
fnp-3806	1771	10	carmona	carmona	PROPN
fnp-3806	1771	11	m	m	PROPN
fnp-3806	1771	12	,	,	PUNCT
fnp-3806	1771	13	et	et	PROPN
fnp-3806	1771	14	al	al	PROPN
fnp-3806	1771	15	.	.	PROPN
fnp-3806	1771	16	glial	glial	ADJ
fnp-3806	1771	17	and	and	CCONJ
fnp-3806	1771	18	neuronal	neuronal	ADJ
fnp-3806	1771	19	tau	tau	PROPN
fnp-3806	1771	20	pathology	pathology	NOUN
fnp-3806	1771	21	in	in	ADP
fnp-3806	1771	22	tauopathies	tauopathie	NOUN
fnp-3806	1771	23	:	:	PUNCT
fnp-3806	1771	24	characterization	characterization	NOUN
fnp-3806	1771	25	of	of	ADP
fnp-3806	1771	26	disease	disease	NOUN
fnp-3806	1771	27	-	-	PUNCT
fnp-3806	1771	28	specific	specific	ADJ
fnp-3806	1771	29	phenotypes	phenotype	NOUN
fnp-3806	1771	30	and	and	CCONJ
fnp-3806	1771	31	tau	tau	PROPN
fnp-3806	1771	32	pathology	pathology	NOUN
fnp-3806	1771	33	progression	progression	NOUN
fnp-3806	1771	34	.	.	PUNCT
fnp-3806	1772	1	j	j	PROPN
fnp-3806	1772	2	neuropathol	neuropathol	PROPN
fnp-3806	1772	3	exp	exp	PROPN
fnp-3806	1772	4	neurol	neurol	PROPN
fnp-3806	1772	5	2014;73:81	2014;73:81	NUM
fnp-3806	1772	6	-	-	SYM
fnp-3806	1772	7	97	97	NUM
fnp-3806	1772	8	.	.	PUNCT
fnp-3806	1773	1	https://doi.org/10.1097/nen.0000000000000030	https://doi.org/10.1097/nen.0000000000000030	PROPN
fnp-3806	1773	2	kametani	kametani	PROPN
fnp-3806	1773	3	f	f	PROPN
fnp-3806	1773	4	,	,	PUNCT
fnp-3806	1773	5	yoshida	yoshida	PROPN
fnp-3806	1773	6	m	m	PROPN
fnp-3806	1773	7	,	,	PUNCT
fnp-3806	1773	8	matsubara	matsubara	PROPN
fnp-3806	1773	9	t	t	PROPN
fnp-3806	1773	10	,	,	PUNCT
fnp-3806	1773	11	et	et	PROPN
fnp-3806	1773	12	al	al	PROPN
fnp-3806	1773	13	.	.	PROPN
fnp-3806	1773	14	comparison	comparison	NOUN
fnp-3806	1773	15	of	of	ADP
fnp-3806	1773	16	common	common	ADJ
fnp-3806	1773	17	and	and	CCONJ
fnp-3806	1773	18	disease	disease	NOUN
fnp-3806	1773	19	-	-	PUNCT
fnp-3806	1773	20	specific	specific	ADJ
fnp-3806	1773	21	post	post	ADJ
fnp-3806	1773	22	-	-	ADJ
fnp-3806	1773	23	translational	translational	ADJ
fnp-3806	1773	24	modifications	modification	NOUN
fnp-3806	1773	25	of	of	ADP
fnp-3806	1773	26	pathological	pathological	ADJ
fnp-3806	1773	27	tau	tau	NOUN
fnp-3806	1773	28	associated	associate	VERB
fnp-3806	1773	29	with	with	ADP
fnp-3806	1773	30	a	a	DET
fnp-3806	1773	31	wide	wide	ADJ
fnp-3806	1773	32	range	range	NOUN
fnp-3806	1773	33	of	of	ADP
fnp-3806	1773	34	tauopathies	tauopathie	NOUN
fnp-3806	1773	35	.	.	PUNCT
fnp-3806	1774	1	front	front	ADJ
fnp-3806	1774	2	neurosci	neurosci	NOUN
fnp-3806	1774	3	2020	2020	NUM
fnp-3806	1774	4	;	;	PUNCT
fnp-3806	1774	5	14	14	NUM
fnp-3806	1774	6	:	:	SYM
fnp-3806	1774	7	581936	581936	NUM
fnp-3806	1774	8	.	.	PUNCT
fnp-3806	1775	1	https://doi.org/10.3389/fnins.2020.581936	https://doi.org/10.3389/fnins.2020.581936	PROPN
fnp-3806	1775	2	wang	wang	PROPN
fnp-3806	1775	3	jz	jz	PROPN
fnp-3806	1775	4	,	,	PUNCT
fnp-3806	1775	5	xia	xia	PROPN
fnp-3806	1775	6	yy	yy	PROPN
fnp-3806	1775	7	,	,	PUNCT
fnp-3806	1775	8	grundke	grundke	NOUN
fnp-3806	1775	9	-	-	PUNCT
fnp-3806	1775	10	iqbal	iqbal	NOUN
fnp-3806	1775	11	i	i	PROPN
fnp-3806	1775	12	,	,	PUNCT
fnp-3806	1775	13	et	et	PROPN
fnp-3806	1775	14	al	al	PROPN
fnp-3806	1775	15	.	.	PROPN
fnp-3806	1775	16	abnormal	abnormal	ADJ
fnp-3806	1775	17	hyperphosphorylation	hyperphosphorylation	NOUN
fnp-3806	1775	18	of	of	ADP
fnp-3806	1775	19	tau	tau	PROPN
fnp-3806	1775	20	:	:	PUNCT
fnp-3806	1775	21	sites	site	NOUN
fnp-3806	1775	22	,	,	PUNCT
fnp-3806	1775	23	regulation	regulation	NOUN
fnp-3806	1775	24	,	,	PUNCT
fnp-3806	1775	25	and	and	CCONJ
fnp-3806	1775	26	molecular	molecular	ADJ
fnp-3806	1775	27	mechanism	mechanism	NOUN
fnp-3806	1775	28	of	of	ADP
fnp-3806	1775	29	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1775	30	degeneration	degeneration	NOUN
fnp-3806	1775	31	.	.	PUNCT
fnp-3806	1776	1	j	j	PROPN
fnp-3806	1776	2	alzheimers	alzheimers	PROPN
fnp-3806	1776	3	dis	dis	PROPN
fnp-3806	1776	4	2013;33	2013;33	NUM
fnp-3806	1776	5	:	:	PUNCT
fnp-3806	1776	6	s123	s123	NOUN
fnp-3806	1776	7	-	-	SYM
fnp-3806	1776	8	139	139	NUM
fnp-3806	1776	9	.	.	PUNCT
fnp-3806	1777	1	https://doi.org/10.3233/jad-2012-129031	https://doi.org/10.3233/jad-2012-129031	NOUN
fnp-3806	1777	2	hanger	hanger	PROPN
fnp-3806	1777	3	dp	dp	PROPN
fnp-3806	1777	4	,	,	PUNCT
fnp-3806	1777	5	anderton	anderton	PROPN
fnp-3806	1777	6	bh	bh	PROPN
fnp-3806	1777	7	,	,	PUNCT
fnp-3806	1777	8	noble	noble	ADJ
fnp-3806	1777	9	w.	w.	PROPN
fnp-3806	1777	10	tau	tau	PROPN
fnp-3806	1777	11	phosphorylation	phosphorylation	NOUN
fnp-3806	1777	12	:	:	PUNCT
fnp-3806	1777	13	the	the	DET
fnp-3806	1777	14	therapeutic	therapeutic	ADJ
fnp-3806	1777	15	challenge	challenge	NOUN
fnp-3806	1777	16	for	for	ADP
fnp-3806	1777	17	neurodegenerative	neurodegenerative	ADJ
fnp-3806	1777	18	disease	disease	NOUN
fnp-3806	1777	19	.	.	PUNCT
fnp-3806	1778	1	trends	trend	NOUN
fnp-3806	1778	2	mol	mol	ADP
fnp-3806	1778	3	med	med	PROPN
fnp-3806	1778	4	2009;15:112	2009;15:112	PROPN
fnp-3806	1778	5	-	-	PUNCT
fnp-3806	1778	6	119	119	NUM
fnp-3806	1778	7	.	.	PUNCT
fnp-3806	1779	1	https://doi.org/10.1016/j.molmed.2009.01.003	https://doi.org/10.1016/j.molmed.2009.01.003	NOUN
fnp-3806	1779	2	ferrer	ferrer	PROPN
fnp-3806	1779	3	i	i	PROPN
fnp-3806	1779	4	,	,	PUNCT
fnp-3806	1779	5	blanco	blanco	PROPN
fnp-3806	1779	6	r	r	PROPN
fnp-3806	1779	7	,	,	PUNCT
fnp-3806	1779	8	carmona	carmona	PROPN
fnp-3806	1779	9	m	m	PROPN
fnp-3806	1779	10	,	,	PUNCT
fnp-3806	1779	11	et	et	PROPN
fnp-3806	1779	12	al	al	PROPN
fnp-3806	1779	13	.	.	PROPN
fnp-3806	1779	14	phosphorylated	phosphorylate	VERB
fnp-3806	1779	15	map	map	NOUN
fnp-3806	1779	16	kinase	kinase	PROPN
fnp-3806	1779	17	(	(	PUNCT
fnp-3806	1779	18	erk1	erk1	PROPN
fnp-3806	1779	19	,	,	PUNCT
fnp-3806	1779	20	erk2	erk2	PROPN
fnp-3806	1779	21	)	)	PUNCT
fnp-3806	1779	22	expression	expression	NOUN
fnp-3806	1779	23	is	be	AUX
fnp-3806	1779	24	associated	associate	VERB
fnp-3806	1779	25	with	with	ADP
fnp-3806	1779	26	early	early	ADJ
fnp-3806	1779	27	tau	tau	PROPN
fnp-3806	1779	28	deposition	deposition	NOUN
fnp-3806	1779	29	in	in	ADP
fnp-3806	1779	30	neurones	neurone	NOUN
fnp-3806	1779	31	and	and	CCONJ
fnp-3806	1779	32	glial	glial	ADJ
fnp-3806	1779	33	cells	cell	NOUN
fnp-3806	1779	34	,	,	PUNCT
fnp-3806	1779	35	but	but	CCONJ
fnp-3806	1779	36	not	not	PART
fnp-3806	1779	37	with	with	ADP
fnp-3806	1779	38	increased	increase	VERB
fnp-3806	1779	39	nuclear	nuclear	ADJ
fnp-3806	1779	40	dna	dna	NOUN
fnp-3806	1779	41	vulnerability	vulnerability	NOUN
fnp-3806	1779	42	and	and	CCONJ
fnp-3806	1779	43	cell	cell	NOUN
fnp-3806	1779	44	death	death	NOUN
fnp-3806	1779	45	,	,	PUNCT
fnp-3806	1779	46	in	in	ADP
fnp-3806	1779	47	alzheimer	alzheimer	PROPN
fnp-3806	1779	48	disease	disease	PROPN
fnp-3806	1779	49	,	,	PUNCT
fnp-3806	1779	50	pick	pick	NOUN
fnp-3806	1779	51	's	's	PART
fnp-3806	1779	52	disease	disease	NOUN
fnp-3806	1779	53	,	,	PUNCT
fnp-3806	1779	54	progressive	progressive	ADJ
fnp-3806	1779	55	supranuclear	supranuclear	ADJ
fnp-3806	1779	56	palsy	palsy	ADJ
fnp-3806	1779	57	and	and	CCONJ
fnp-3806	1779	58	corticobasal	corticobasal	NOUN
fnp-3806	1779	59	degeneration	degeneration	NOUN
fnp-3806	1779	60	.	.	PUNCT
fnp-3806	1780	1	brain	brain	NOUN
fnp-3806	1780	2	pathol	pathol	PROPN
fnp-3806	1780	3	2001;11:144	2001;11:144	PROPN
fnp-3806	1780	4	-	-	SYM
fnp-3806	1780	5	158	158	NUM
fnp-3806	1780	6	.	.	PUNCT
fnp-3806	1781	1	https://doi.org/10.1111/j.1750-3639.2001.tb00387.x	https://doi.org/10.1111/j.1750-3639.2001.tb00387.x	PRON
fnp-3806	1782	1	ferrer	ferrer	PROPN
fnp-3806	1782	2	i	i	PROPN
fnp-3806	1782	3	,	,	PUNCT
fnp-3806	1782	4	blanco	blanco	PROPN
fnp-3806	1782	5	r	r	PROPN
fnp-3806	1782	6	,	,	PUNCT
fnp-3806	1782	7	carmona	carmona	PROPN
fnp-3806	1782	8	m	m	PROPN
fnp-3806	1782	9	,	,	PUNCT
fnp-3806	1782	10	et	et	PROPN
fnp-3806	1782	11	al	al	PROPN
fnp-3806	1782	12	.	.	PROPN
fnp-3806	1782	13	phosphorylated	phosphorylate	VERB
fnp-3806	1782	14	mitogen	mitogen	NOUN
fnp-3806	1782	15	-	-	PUNCT
fnp-3806	1782	16	activated	activate	VERB
fnp-3806	1782	17	protein	protein	NOUN
fnp-3806	1782	18	kinase	kinase	NOUN
fnp-3806	1782	19	(	(	PUNCT
fnp-3806	1782	20	mapk	mapk	PROPN
fnp-3806	1782	21	/	/	SYM
fnp-3806	1782	22	erk	erk	PROPN
fnp-3806	1782	23	-	-	PUNCT
fnp-3806	1782	24	p	p	PROPN
fnp-3806	1782	25	)	)	PUNCT
fnp-3806	1782	26	,	,	PUNCT
fnp-3806	1782	27	protein	protein	NOUN
fnp-3806	1782	28	kinase	kinase	NOUN
fnp-3806	1782	29	of	of	ADP
fnp-3806	1782	30	38	38	NUM
fnp-3806	1782	31	kda	kda	NOUN
fnp-3806	1782	32	(	(	PUNCT
fnp-3806	1782	33	p38	p38	NOUN
fnp-3806	1782	34	-	-	PUNCT
fnp-3806	1782	35	p	p	NOUN
fnp-3806	1782	36	)	)	PUNCT
fnp-3806	1782	37	,	,	PUNCT
fnp-3806	1782	38	stress	stress	NOUN
fnp-3806	1782	39	-	-	PUNCT
fnp-3806	1782	40	activated	activate	VERB
fnp-3806	1782	41	protein	protein	NOUN
fnp-3806	1782	42	kinase	kinase	NOUN
fnp-3806	1782	43	(	(	PUNCT
fnp-3806	1782	44	sapk	sapk	PROPN
fnp-3806	1782	45	/	/	SYM
fnp-3806	1782	46	jnk	jnk	PROPN
fnp-3806	1782	47	-	-	PUNCT
fnp-3806	1782	48	p	p	PROPN
fnp-3806	1782	49	)	)	PUNCT
fnp-3806	1782	50	,	,	PUNCT
fnp-3806	1782	51	and	and	CCONJ
fnp-3806	1782	52	calcium	calcium	NOUN
fnp-3806	1782	53	/	/	SYM
fnp-3806	1782	54	calmodulin	calmodulin	NOUN
fnp-3806	1782	55	-	-	PUNCT
fnp-3806	1782	56	dependent	dependent	ADJ
fnp-3806	1782	57	kinase	kinase	PROPN
fnp-3806	1782	58	ii	ii	PROPN
fnp-3806	1783	1	(	(	PUNCT
fnp-3806	1783	2	cam	cam	VERB
fnp-3806	1783	3	kinase	kinase	PROPN
fnp-3806	1783	4	ii	ii	PROPN
fnp-3806	1783	5	)	)	PUNCT
fnp-3806	1783	6	are	be	AUX
fnp-3806	1783	7	differentially	differentially	ADV
fnp-3806	1783	8	expressed	express	VERB
fnp-3806	1783	9	in	in	ADP
fnp-3806	1783	10	tau	tau	PROPN
fnp-3806	1783	11	deposits	deposit	NOUN
fnp-3806	1783	12	in	in	ADP
fnp-3806	1783	13	neurons	neuron	NOUN
fnp-3806	1783	14	and	and	CCONJ
fnp-3806	1783	15	glial	glial	ADJ
fnp-3806	1783	16	cells	cell	NOUN
fnp-3806	1783	17	in	in	ADP
fnp-3806	1783	18	tauopathies	tauopathie	NOUN
fnp-3806	1783	19	.	.	PUNCT
fnp-3806	1784	1	j	j	PROPN
fnp-3806	1784	2	neural	neural	PROPN
fnp-3806	1784	3	transm	transm	PROPN
fnp-3806	1784	4	2001;108:1397	2001;108:1397	NUM
fnp-3806	1784	5	-	-	SYM
fnp-3806	1784	6	415	415	NUM
fnp-3806	1784	7	.	.	PUNCT
fnp-3806	1785	1	https://doi.org/10.1007/s007020100016	https://doi.org/10.1007/s007020100016	NUM
fnp-3806	1785	2	ferrer	ferrer	PROPN
fnp-3806	1785	3	i	i	PROPN
fnp-3806	1785	4	,	,	PUNCT
fnp-3806	1785	5	gomez	gomez	PROPN
fnp-3806	1785	6	-	-	PUNCT
fnp-3806	1785	7	isla	isla	PROPN
fnp-3806	1785	8	t	t	PROPN
fnp-3806	1785	9	,	,	PUNCT
fnp-3806	1785	10	puig	puig	PROPN
fnp-3806	1785	11	b	b	PROPN
fnp-3806	1785	12	,	,	PUNCT
fnp-3806	1785	13	et	et	PROPN
fnp-3806	1785	14	al	al	PROPN
fnp-3806	1785	15	.	.	PUNCT
fnp-3806	1786	1	current	current	ADJ
fnp-3806	1786	2	advances	advance	NOUN
fnp-3806	1786	3	on	on	ADP
fnp-3806	1786	4	different	different	ADJ
fnp-3806	1786	5	kinases	kinase	NOUN
fnp-3806	1786	6	involved	involve	VERB
fnp-3806	1786	7	in	in	ADP
fnp-3806	1786	8	tau	tau	PROPN
fnp-3806	1786	9	phosphorylation	phosphorylation	NOUN
fnp-3806	1786	10	,	,	PUNCT
fnp-3806	1786	11	and	and	CCONJ
fnp-3806	1786	12	implications	implication	NOUN
fnp-3806	1786	13	in	in	ADP
fnp-3806	1786	14	alzheimer	alzheimer	PROPN
fnp-3806	1786	15	's	's	PART
fnp-3806	1786	16	disease	disease	NOUN
fnp-3806	1786	17	and	and	CCONJ
fnp-3806	1786	18	tauopathies	tauopathie	NOUN
fnp-3806	1786	19	.	.	PUNCT
fnp-3806	1787	1	curr	curr	PROPN
fnp-3806	1787	2	alzheimer	alzheimer	PROPN
fnp-3806	1787	3	res	res	PROPN
fnp-3806	1787	4	2005;2:3	2005;2:3	NOUN
fnp-3806	1787	5	-	-	SYM
fnp-3806	1787	6	18	18	NUM
fnp-3806	1787	7	.	.	PUNCT
fnp-3806	1788	1	https://doi.org/10.2174/1567205052772713	https://doi.org/10.2174/1567205052772713	PRON
fnp-3806	1788	2	guimaraes	guimaraes	PROPN
fnp-3806	1788	3	tr	tr	VERB
fnp-3806	1788	4	,	,	PUNCT
fnp-3806	1788	5	swanson	swanson	PROPN
fnp-3806	1788	6	e	e	PROPN
fnp-3806	1788	7	,	,	PUNCT
fnp-3806	1788	8	kofler	kofler	PROPN
fnp-3806	1788	9	j	j	PROPN
fnp-3806	1788	10	,	,	PUNCT
fnp-3806	1788	11	et	et	PROPN
fnp-3806	1788	12	al	al	PROPN
fnp-3806	1788	13	.	.	PUNCT
fnp-3806	1789	1	g	g	NOUN
fnp-3806	1789	2	-	-	PUNCT
fnp-3806	1789	3	protein	protein	NOUN
fnp-3806	1789	4	-	-	PUNCT
fnp-3806	1789	5	coupled	couple	VERB
fnp-3806	1789	6	receptor	receptor	NOUN
fnp-3806	1789	7	kinases	kinase	NOUN
fnp-3806	1789	8	are	be	AUX
fnp-3806	1789	9	associated	associate	VERB
fnp-3806	1789	10	with	with	ADP
fnp-3806	1789	11	alzheimer	alzheimer	PROPN
fnp-3806	1789	12	’s	’s	PART
fnp-3806	1789	13	disease	disease	NOUN
fnp-3806	1789	14	pathology	pathology	PROPN
fnp-3806	1789	15	.	.	PUNCT
fnp-3806	1790	1	neuropathol	neuropathol	PROPN
fnp-3806	1790	2	appl	appl	PROPN
fnp-3806	1790	3	neurobiol	neurobiol	PROPN
fnp-3806	1790	4	2021;47:942	2021;47:942	PROPN
fnp-3806	1790	5	-	-	SYM
fnp-3806	1790	6	957	957	NUM
fnp-3806	1790	7	.	.	PUNCT
fnp-3806	1791	1	https://doi.org/10.1111/nan.12742	https://doi.org/10.1111/nan.12742	PROPN
fnp-3806	1791	2	cowan	cowan	PROPN
fnp-3806	1791	3	cm	cm	PROPN
fnp-3806	1791	4	,	,	PUNCT
fnp-3806	1791	5	quraishe	quraishe	PROPN
fnp-3806	1791	6	s	s	PROPN
fnp-3806	1791	7	,	,	PUNCT
fnp-3806	1791	8	mudher	mudher	VERB
fnp-3806	1791	9	a	a	PRON
fnp-3806	1791	10	what	what	PRON
fnp-3806	1791	11	is	be	AUX
fnp-3806	1791	12	the	the	DET
fnp-3806	1791	13	pathological	pathological	ADJ
fnp-3806	1791	14	significance	significance	NOUN
fnp-3806	1791	15	of	of	ADP
fnp-3806	1791	16	tau	tau	PROPN
fnp-3806	1791	17	oligomers	oligomer	NOUN
fnp-3806	1791	18	?	?	PUNCT
fnp-3806	1792	1	biochem	biochem	PROPN
fnp-3806	1792	2	soc	soc	VERB
fnp-3806	1792	3	trans	trans	PROPN
fnp-3806	1792	4	2012;40:693	2012;40:693	PROPN
fnp-3806	1792	5	-	-	PUNCT
fnp-3806	1792	6	697	697	NUM
fnp-3806	1792	7	.	.	PUNCT
fnp-3806	1793	1	https://doi.org/10.1042/bst20120135	https://doi.org/10.1042/bst20120135	PROPN
fnp-3806	1793	2	moraga	moraga	PROPN
fnp-3806	1793	3	dm	dm	PROPN
fnp-3806	1793	4	,	,	PUNCT
fnp-3806	1793	5	nunez	nunez	PROPN
fnp-3806	1793	6	p	p	PROPN
fnp-3806	1793	7	,	,	PUNCT
fnp-3806	1793	8	garrido	garrido	PROPN
fnp-3806	1793	9	j	j	PROPN
fnp-3806	1793	10	,	,	PUNCT
fnp-3806	1793	11	et	et	PROPN
fnp-3806	1793	12	al	al	PROPN
fnp-3806	1793	13	.	.	PUNCT
fnp-3806	1794	1	a	a	DET
fnp-3806	1794	2	tau	tau	PROPN
fnp-3806	1794	3	fragment	fragment	NOUN
fnp-3806	1794	4	containing	contain	VERB
fnp-3806	1794	5	a	a	DET
fnp-3806	1794	6	repetitive	repetitive	ADJ
fnp-3806	1794	7	sequence	sequence	NOUN
fnp-3806	1794	8	induces	induce	VERB
fnp-3806	1794	9	bundling	bundle	VERB
fnp-3806	1794	10	of	of	ADP
fnp-3806	1794	11	actin	actin	NOUN
fnp-3806	1794	12	filaments	filament	NOUN
fnp-3806	1794	13	.	.	PUNCT
fnp-3806	1795	1	j	j	PROPN
fnp-3806	1795	2	neurochem	neurochem	ADV
fnp-3806	1795	3	1993;61:979	1993;61:979	NUM
fnp-3806	1795	4	-	-	PUNCT
fnp-3806	1795	5	986	986	NUM
fnp-3806	1795	6	.	.	PUNCT
fnp-3806	1796	1	https://doi.org/10.1111/j.1471-4159.1993	https://doi.org/10.1111/j.1471-4159.1993	NOUN
fnp-3806	1796	2	tb03611.x	tb03611.x	NOUN
fnp-3806	1796	3	.	.	PUNCT
fnp-3806	1797	1	maas	maas	PROPN
fnp-3806	1797	2	t	t	PROPN
fnp-3806	1797	3	,	,	PUNCT
fnp-3806	1797	4	eidenmüller	eidenmüller	PROPN
fnp-3806	1797	5	j	j	PROPN
fnp-3806	1797	6	,	,	PUNCT
fnp-3806	1797	7	brandt	brandt	PROPN
fnp-3806	1797	8	r.	r.	PROPN
fnp-3806	1797	9	interaction	interaction	NOUN
fnp-3806	1797	10	of	of	ADP
fnp-3806	1797	11	tau	tau	PROPN
fnp-3806	1797	12	with	with	ADP
fnp-3806	1797	13	the	the	DET
fnp-3806	1797	14	neural	neural	ADJ
fnp-3806	1797	15	membrane	membrane	NOUN
fnp-3806	1797	16	cortex	cortex	NOUN
fnp-3806	1797	17	is	be	AUX
fnp-3806	1797	18	regulated	regulate	VERB
fnp-3806	1797	19	by	by	ADP
fnp-3806	1797	20	phosphorylation	phosphorylation	NOUN
fnp-3806	1797	21	at	at	ADP
fnp-3806	1797	22	sites	site	NOUN
fnp-3806	1797	23	that	that	PRON
fnp-3806	1797	24	are	be	AUX
fnp-3806	1797	25	modified	modify	VERB
fnp-3806	1797	26	in	in	ADP
fnp-3806	1797	27	paired	pair	VERB
fnp-3806	1797	28	helical	helical	ADJ
fnp-3806	1797	29	filaments	filament	NOUN
fnp-3806	1797	30	.	.	PUNCT
fnp-3806	1798	1	j	j	PROPN
fnp-3806	1798	2	biol	biol	PROPN
fnp-3806	1798	3	chem	chem	NOUN
fnp-3806	1798	4	2000;275:15733	2000;275:15733	NUM
fnp-3806	1798	5	-	-	SYM
fnp-3806	1798	6	15740	15740	NUM
fnp-3806	1798	7	.	.	PUNCT
fnp-3806	1799	1	https://doi.org/10.1074/jbc.m00038920	https://doi.org/10.1074/jbc.m00038920	X
fnp-3806	1799	2	shea	shea	PROPN
fnp-3806	1799	3	tb	tb	PROPN
fnp-3806	1799	4	,	,	PUNCT
fnp-3806	1799	5	chan	chan	PROPN
fnp-3806	1799	6	a.	a.	PROPN
fnp-3806	1799	7	s	s	PROPN
fnp-3806	1799	8	-	-	PUNCT
fnp-3806	1799	9	adenosyl	adenosyl	NOUN
fnp-3806	1799	10	methionine	methionine	NOUN
fnp-3806	1799	11	:	:	PUNCT
fnp-3806	1799	12	a	a	DET
fnp-3806	1799	13	natural	natural	ADJ
fnp-3806	1799	14	therapeutic	therapeutic	ADJ
fnp-3806	1799	15	agent	agent	NOUN
fnp-3806	1799	16	effective	effective	ADJ
fnp-3806	1799	17	against	against	ADP
fnp-3806	1799	18	multiple	multiple	ADJ
fnp-3806	1799	19	hallmarks	hallmark	NOUN
fnp-3806	1799	20	and	and	CCONJ
fnp-3806	1799	21	risk	risk	NOUN
fnp-3806	1799	22	factors	factor	NOUN
fnp-3806	1799	23	associated	associate	VERB
fnp-3806	1799	24	with	with	ADP
fnp-3806	1799	25	alzheimer	alzheimer	PROPN
fnp-3806	1799	26	's	's	PART
fnp-3806	1799	27	disease	disease	NOUN
fnp-3806	1799	28	.	.	PUNCT
fnp-3806	1800	1	j	j	PROPN
fnp-3806	1800	2	alzheimers	alzheimers	PROPN
fnp-3806	1800	3	dis	dis	PROPN
fnp-3806	1800	4	2008;13:67	2008;13:67	NUM
fnp-3806	1800	5	-	-	SYM
fnp-3806	1800	6	70	70	NUM
fnp-3806	1800	7	.	.	PUNCT
fnp-3806	1801	1	https://doi.org/10.3233/jad-2008-13107	https://doi.org/10.3233/jad-2008-13107	PROPN
fnp-3806	1801	2	schneider	schneider	PROPN
fnp-3806	1801	3	a	a	PROPN
fnp-3806	1801	4	,	,	PUNCT
fnp-3806	1801	5	biernat	biernat	PROPN
fnp-3806	1801	6	j	j	PROPN
fnp-3806	1801	7	,	,	PUNCT
fnp-3806	1801	8	von	von	PROPN
fnp-3806	1801	9	bergen	bergen	PROPN
fnp-3806	1801	10	m	m	PROPN
fnp-3806	1801	11	,	,	PUNCT
fnp-3806	1801	12	et	et	PROPN
fnp-3806	1801	13	al	al	PROPN
fnp-3806	1801	14	.	.	PROPN
fnp-3806	1801	15	phosphorylation	phosphorylation	NOUN
fnp-3806	1801	16	that	that	PRON
fnp-3806	1801	17	detaches	detach	VERB
fnp-3806	1801	18	tau	tau	PROPN
fnp-3806	1801	19	protein	protein	NOUN
fnp-3806	1801	20	from	from	ADP
fnp-3806	1801	21	microtubules	microtubule	NOUN
fnp-3806	1801	22	(	(	PUNCT
fnp-3806	1801	23	ser262	ser262	PROPN
fnp-3806	1801	24	,	,	PUNCT
fnp-3806	1801	25	ser214	ser214	ADJ
fnp-3806	1801	26	)	)	PUNCT
fnp-3806	1801	27	also	also	ADV
fnp-3806	1801	28	protects	protect	VERB
fnp-3806	1801	29	it	it	PRON
fnp-3806	1801	30	against	against	ADP
fnp-3806	1801	31	aggregation	aggregation	NOUN
fnp-3806	1801	32	into	into	ADP
fnp-3806	1801	33	alzheimer	alzheimer	PROPN
fnp-3806	1801	34	paired	pair	VERB
fnp-3806	1801	35	helical	helical	ADJ
fnp-3806	1801	36	filaments	filament	NOUN
fnp-3806	1801	37	.	.	PUNCT
fnp-3806	1802	1	biochemistry	biochemistry	NOUN
fnp-3806	1802	2	1999;38:3549	1999;38:3549	NUM
fnp-3806	1802	3	-	-	SYM
fnp-3806	1802	4	3558	3558	NUM
fnp-3806	1802	5	.	.	PUNCT
fnp-3806	1803	1	https://doi.org/10.1021/bi981874p	https://doi.org/10.1021/bi981874p	PROPN
fnp-3806	1803	2	farias	farias	PROPN
fnp-3806	1803	3	ga	ga	PROPN
fnp-3806	1803	4	,	,	PUNCT
fnp-3806	1803	5	muñoz	muñoz	PROPN
fnp-3806	1803	6	jp	jp	PROPN
fnp-3806	1803	7	,	,	PUNCT
fnp-3806	1803	8	garrido	garrido	PROPN
fnp-3806	1803	9	j	j	PROPN
fnp-3806	1803	10	,	,	PUNCT
fnp-3806	1803	11	et	et	PROPN
fnp-3806	1803	12	al	al	PROPN
fnp-3806	1803	13	.	.	PUNCT
fnp-3806	1803	14	tubulin	tubulin	NOUN
fnp-3806	1803	15	,	,	PUNCT
fnp-3806	1803	16	actin	actin	NOUN
fnp-3806	1803	17	,	,	PUNCT
fnp-3806	1803	18	and	and	CCONJ
fnp-3806	1803	19	tau	tau	PROPN
fnp-3806	1803	20	protein	protein	NOUN
fnp-3806	1803	21	interactions	interaction	NOUN
fnp-3806	1803	22	and	and	CCONJ
fnp-3806	1803	23	the	the	DET
fnp-3806	1803	24	study	study	NOUN
fnp-3806	1803	25	of	of	ADP
fnp-3806	1803	26	their	their	PRON
fnp-3806	1803	27	macromolecular	macromolecular	ADJ
fnp-3806	1803	28	assemblies	assembly	NOUN
fnp-3806	1803	29	.	.	PUNCT
fnp-3806	1804	1	j	j	PROPN
fnp-3806	1804	2	cell	cell	PROPN
fnp-3806	1804	3	biochem	biochem	NOUN
fnp-3806	1804	4	2002;85:315	2002;85:315	NOUN
fnp-3806	1804	5	-	-	X
fnp-3806	1804	6	324	324	NUM
fnp-3806	1804	7	.	.	PUNCT
fnp-3806	1805	1	https://doi.org/10.1002/jcb.10133	https://doi.org/10.1002/jcb.10133	PROPN
fnp-3806	1805	2	mohan	mohan	PROPN
fnp-3806	1805	3	r	r	PROPN
fnp-3806	1805	4	,	,	PUNCT
fnp-3806	1805	5	john	john	PROPN
fnp-3806	1805	6	a.	a.	NOUN
fnp-3806	1805	7	microtubule	microtubule	PROPN
fnp-3806	1805	8	-	-	PUNCT
fnp-3806	1805	9	associated	associate	VERB
fnp-3806	1805	10	proteins	protein	NOUN
fnp-3806	1805	11	as	as	ADP
fnp-3806	1805	12	direct	direct	ADJ
fnp-3806	1805	13	crosslinkers	crosslinker	NOUN
fnp-3806	1805	14	of	of	ADP
fnp-3806	1805	15	actin	actin	NOUN
fnp-3806	1805	16	filaments	filament	NOUN
fnp-3806	1805	17	and	and	CCONJ
fnp-3806	1805	18	microtubules	microtubule	NOUN
fnp-3806	1805	19	.	.	PUNCT
fnp-3806	1806	1	iubmb	iubmb	NOUN
fnp-3806	1806	2	life	life	NOUN
fnp-3806	1806	3	2015;67:395	2015;67:395	PROPN
fnp-3806	1806	4	-	-	PUNCT
fnp-3806	1806	5	403	403	NUM
fnp-3806	1806	6	.	.	PUNCT
fnp-3806	1807	1	https://doi.org/10.1002/iub.1384	https://doi.org/10.1002/iub.1384	PROPN
fnp-3806	1807	2	sallaberry	sallaberry	PROPN
fnp-3806	1807	3	ca	ca	PROPN
fnp-3806	1807	4	,	,	PUNCT
fnp-3806	1807	5	voss	voss	PROPN
fnp-3806	1807	6	bj	bj	PROPN
fnp-3806	1807	7	,	,	PUNCT
fnp-3806	1807	8	majewski	majewski	PROPN
fnp-3806	1807	9	j	j	PROPN
fnp-3806	1807	10	,	,	PUNCT
fnp-3806	1807	11	et	et	PROPN
fnp-3806	1807	12	al	al	PROPN
fnp-3806	1807	13	.	.	PUNCT
fnp-3806	1807	14	tau	tau	PROPN
fnp-3806	1807	15	and	and	CCONJ
fnp-3806	1807	16	membranes	membrane	NOUN
fnp-3806	1807	17	:	:	PUNCT
fnp-3806	1807	18	interactions	interaction	NOUN
fnp-3806	1807	19	that	that	PRON
fnp-3806	1807	20	promote	promote	VERB
fnp-3806	1807	21	folding	folding	NOUN
fnp-3806	1807	22	and	and	CCONJ
fnp-3806	1807	23	condensation	condensation	NOUN
fnp-3806	1807	24	.	.	PUNCT
fnp-3806	1808	1	front	front	ADJ
fnp-3806	1808	2	cell	cell	NOUN
fnp-3806	1808	3	develop	develop	VERB
fnp-3806	1808	4	biol	biol	PROPN
fnp-3806	1808	5	2021;9:725241	2021;9:725241	NUM
fnp-3806	1808	6	.	.	PUNCT
fnp-3806	1809	1	https://doi.org/10.3389/fcell.2021.725241	https://doi.org/10.3389/fcell.2021.725241	PROPN
fnp-3806	1809	2	brunello	brunello	PROPN
fnp-3806	1809	3	ca	ca	PROPN
fnp-3806	1809	4	,	,	PUNCT
fnp-3806	1809	5	merezhko	merezhko	PROPN
fnp-3806	1809	6	m	m	PROPN
fnp-3806	1809	7	,	,	PUNCT
fnp-3806	1809	8	uronen	uronen	PROPN
fnp-3806	1809	9	rl	rl	PROPN
fnp-3806	1809	10	,	,	PUNCT
fnp-3806	1809	11	et	et	PROPN
fnp-3806	1809	12	al	al	PROPN
fnp-3806	1809	13	.	.	PROPN
fnp-3806	1810	1	mechanisms	mechanism	NOUN
fnp-3806	1810	2	of	of	ADP
fnp-3806	1810	3	secretion	secretion	NOUN
fnp-3806	1810	4	and	and	CCONJ
fnp-3806	1810	5	spreading	spread	VERB
fnp-3806	1810	6	of	of	ADP
fnp-3806	1810	7	pathological	pathological	ADJ
fnp-3806	1810	8	tau	tau	PROPN
fnp-3806	1810	9	protein	protein	NOUN
fnp-3806	1810	10	.	.	PUNCT
fnp-3806	1811	1	cell	cell	NOUN
fnp-3806	1811	2	mol	mol	ADP
fnp-3806	1811	3	life	life	NOUN
fnp-3806	1811	4	sci	sci	PROPN
fnp-3806	1811	5	2020;77:1721	2020;77:1721	PROPN
fnp-3806	1811	6	-	-	PUNCT
fnp-3806	1811	7	1744	1744	NUM
fnp-3806	1811	8	.	.	PUNCT
fnp-3806	1812	1	https://doi.org/10.1007/s00018-019-03349-1	https://doi.org/10.1007/s00018-019-03349-1	NUM
fnp-3806	1812	2	bok	bok	PROPN
fnp-3806	1812	3	e	e	PROPN
fnp-3806	1812	4	,	,	PUNCT
fnp-3806	1812	5	leem	leem	PROPN
fnp-3806	1812	6	e	e	PROPN
fnp-3806	1812	7	,	,	PUNCT
fnp-3806	1812	8	lee	lee	PROPN
fnp-3806	1812	9	br	br	PROPN
fnp-3806	1812	10	,	,	PUNCT
fnp-3806	1812	11	et	et	PROPN
fnp-3806	1812	12	al	al	PROPN
fnp-3806	1812	13	.	.	PUNCT
fnp-3806	1812	14	role	role	NOUN
fnp-3806	1812	15	of	of	ADP
fnp-3806	1812	16	the	the	DET
fnp-3806	1812	17	lipid	lipid	NOUN
fnp-3806	1812	18	membrane	membrane	NOUN
fnp-3806	1812	19	and	and	CCONJ
fnp-3806	1812	20	membrane	membrane	NOUN
fnp-3806	1812	21	proteins	protein	NOUN
fnp-3806	1812	22	in	in	ADP
fnp-3806	1812	23	tau	tau	PROPN
fnp-3806	1812	24	pathology	pathology	NOUN
fnp-3806	1812	25	.	.	PUNCT
fnp-3806	1813	1	front	front	ADJ
fnp-3806	1813	2	cell	cell	NOUN
fnp-3806	1813	3	dev	dev	PROPN
fnp-3806	1813	4	biol	biol	PROPN
fnp-3806	1813	5	2021;9:653815	2021;9:653815	NOUN
fnp-3806	1813	6	.	.	PUNCT
fnp-3806	1814	1	https://doi.org/10.3389/fcell.2021.653815	https://doi.org/10.3389/fcell.2021.653815	PROPN
fnp-3806	1814	2	annadurai	annadurai	NOUN
fnp-3806	1814	3	n	n	CCONJ
fnp-3806	1814	4	,	,	PUNCT
fnp-3806	1814	5	de	de	PROPN
fnp-3806	1814	6	sanctis	sanctis	PROPN
fnp-3806	1814	7	jb	jb	PROPN
fnp-3806	1814	8	,	,	PUNCT
fnp-3806	1814	9	hajdúch	hajdúch	PROPN
fnp-3806	1814	10	m	m	PROPN
fnp-3806	1814	11	,	,	PUNCT
fnp-3806	1814	12	et	et	PROPN
fnp-3806	1814	13	al	al	PROPN
fnp-3806	1814	14	.	.	PUNCT
fnp-3806	1815	1	tau	tau	PROPN
fnp-3806	1815	2	secretion	secretion	NOUN
fnp-3806	1815	3	and	and	CCONJ
fnp-3806	1815	4	propagation	propagation	NOUN
fnp-3806	1815	5	:	:	PUNCT
fnp-3806	1815	6	perspectives	perspective	NOUN
fnp-3806	1815	7	for	for	ADP
fnp-3806	1815	8	potential	potential	ADJ
fnp-3806	1815	9	preventive	preventive	ADJ
fnp-3806	1815	10	interventions	intervention	NOUN
fnp-3806	1815	11	in	in	ADP
fnp-3806	1815	12	alzheimer	alzheimer	PROPN
fnp-3806	1815	13	's	's	PART
fnp-3806	1815	14	disease	disease	NOUN
fnp-3806	1815	15	and	and	CCONJ
fnp-3806	1815	16	other	other	ADJ
fnp-3806	1815	17	tauopathies	tauopathie	NOUN
fnp-3806	1815	18	.	.	PUNCT
fnp-3806	1816	1	exp	exp	NOUN
fnp-3806	1816	2	neurol	neurol	NOUN
fnp-3806	1816	3	2021;343:113756	2021;343:113756	NUM
fnp-3806	1816	4	.	.	PUNCT
fnp-3806	1817	1	https://doi.org/10.1016/j.expneurol.2021.113756	https://doi.org/10.1016/j.expneurol.2021.113756	PROPN
fnp-3806	1817	2	santa	santa	PROPN
fnp-3806	1817	3	-	-	PUNCT
fnp-3806	1817	4	maria	maria	PROPN
fnp-3806	1817	5	i	i	PROPN
fnp-3806	1817	6	,	,	PUNCT
fnp-3806	1817	7	varghese	varghese	PROPN
fnp-3806	1817	8	m	m	PROPN
fnp-3806	1817	9	,	,	PUNCT
fnp-3806	1817	10	ksiéżak	ksiéżak	NOUN
fnp-3806	1817	11	-	-	PUNCT
fnp-3806	1817	12	reding	rede	VERB
fnp-3806	1817	13	h	h	NOUN
fnp-3806	1817	14	,	,	PUNCT
fnp-3806	1817	15	et	et	PROPN
fnp-3806	1817	16	al	al	PROPN
fnp-3806	1817	17	.	.	PROPN
fnp-3806	1817	18	paired	pair	VERB
fnp-3806	1817	19	helical	helical	ADJ
fnp-3806	1817	20	filaments	filament	NOUN
fnp-3806	1817	21	from	from	ADP
fnp-3806	1817	22	alzheimer	alzheimer	PROPN
fnp-3806	1817	23	disease	disease	NOUN
fnp-3806	1817	24	brain	brain	NOUN
fnp-3806	1817	25	induces	induce	VERB
fnp-3806	1817	26	intracellular	intracellular	ADJ
fnp-3806	1817	27	accumulation	accumulation	NOUN
fnp-3806	1817	28	of	of	ADP
fnp-3806	1817	29	tau	tau	PROPN
fnp-3806	1817	30	protein	protein	NOUN
fnp-3806	1817	31	in	in	ADP
fnp-3806	1817	32	aggresomes	aggresome	NOUN
fnp-3806	1817	33	.	.	PUNCT
fnp-3806	1818	1	j	j	PROPN
fnp-3806	1818	2	biol	biol	PROPN
fnp-3806	1818	3	chem	chem	NOUN
fnp-3806	1818	4	2012	2012	NUM
fnp-3806	1818	5	:	:	PUNCT
fnp-3806	1818	6	287	287	NUM
fnp-3806	1818	7	:	:	PUNCT
fnp-3806	1818	8	2052220533	2052220533	NUM
fnp-3806	1818	9	.	.	PUNCT
fnp-3806	1819	1	https://doi.org/10.1074/jbc.m111.323279	https://doi.org/10.1074/jbc.m111.323279	PROPN
fnp-3806	1819	2	falcon	falcon	PROPN
fnp-3806	1819	3	b	b	PROPN
fnp-3806	1819	4	,	,	PUNCT
fnp-3806	1819	5	zhang	zhang	PROPN
fnp-3806	1819	6	w	w	PROPN
fnp-3806	1819	7	,	,	PUNCT
fnp-3806	1819	8	schweighauser	schweighauser	NOUN
fnp-3806	1819	9	m	m	PROPN
fnp-3806	1819	10	,	,	PUNCT
fnp-3806	1819	11	et	et	PROPN
fnp-3806	1819	12	al	al	PROPN
fnp-3806	1819	13	.	.	PUNCT
fnp-3806	1820	1	tau	tau	PROPN
fnp-3806	1820	2	filaments	filament	VERB
fnp-3806	1820	3	from	from	ADP
fnp-3806	1820	4	multiple	multiple	ADJ
fnp-3806	1820	5	cases	case	NOUN
fnp-3806	1820	6	of	of	ADP
fnp-3806	1820	7	sporadic	sporadic	ADJ
fnp-3806	1820	8	and	and	CCONJ
fnp-3806	1820	9	inherited	inherit	VERB
fnp-3806	1820	10	alzheimer	alzheimer	PROPN
fnp-3806	1820	11	's	's	PART
fnp-3806	1820	12	disease	disease	NOUN
fnp-3806	1820	13	adopt	adopt	VERB
fnp-3806	1820	14	a	a	DET
fnp-3806	1820	15	common	common	ADJ
fnp-3806	1820	16	fold	fold	NOUN
fnp-3806	1820	17	.	.	PUNCT
fnp-3806	1821	1	acta	acta	PROPN
fnp-3806	1821	2	neuropathol	neuropathol	PROPN
fnp-3806	1821	3	2018;136:699	2018;136:699	NUM
fnp-3806	1821	4	-	-	SYM
fnp-3806	1821	5	708	708	NUM
fnp-3806	1821	6	.	.	PUNCT
fnp-3806	1822	1	https://doi.org/10.1007/s00401-018-1914-z	https://doi.org/10.1007/s00401-018-1914-z	ADJ
fnp-3806	1822	2	falcon	falcon	PROPN
fnp-3806	1822	3	b	b	PROPN
fnp-3806	1822	4	,	,	PUNCT
fnp-3806	1822	5	zhang	zhang	PROPN
fnp-3806	1822	6	w	w	PROPN
fnp-3806	1822	7	,	,	PUNCT
fnp-3806	1822	8	murzin	murzin	PROPN
fnp-3806	1822	9	ag	ag	PROPN
fnp-3806	1822	10	,	,	PUNCT
fnp-3806	1822	11	et	et	PROPN
fnp-3806	1822	12	al	al	PROPN
fnp-3806	1822	13	.	.	PROPN
fnp-3806	1822	14	structures	structure	NOUN
fnp-3806	1822	15	of	of	ADP
fnp-3806	1822	16	filaments	filament	NOUN
fnp-3806	1822	17	from	from	ADP
fnp-3806	1822	18	pick	pick	NOUN
fnp-3806	1822	19	's	's	PART
fnp-3806	1822	20	disease	disease	NOUN
fnp-3806	1822	21	reveal	reveal	VERB
fnp-3806	1822	22	a	a	DET
fnp-3806	1822	23	novel	novel	NOUN
fnp-3806	1822	24	tau	tau	NOUN
fnp-3806	1822	25	protein	protein	NOUN
fnp-3806	1822	26	fold	fold	NOUN
fnp-3806	1822	27	.	.	PUNCT
fnp-3806	1823	1	nature	nature	NOUN
fnp-3806	1823	2	2018;561:137	2018;561:137	NUM
fnp-3806	1823	3	-	-	SYM
fnp-3806	1823	4	140	140	NUM
fnp-3806	1823	5	.	.	PUNCT
fnp-3806	1824	1	https://doi.org/10.1038/s41586-018-0454-y	https://doi.org/10.1038/s41586-018-0454-y	PROPN
fnp-3806	1824	2	falcon	falcon	PROPN
fnp-3806	1824	3	b	b	PROPN
fnp-3806	1824	4	,	,	PUNCT
fnp-3806	1824	5	zivanov	zivanov	PROPN
fnp-3806	1824	6	j	j	PROPN
fnp-3806	1824	7	,	,	PUNCT
fnp-3806	1824	8	zhang	zhang	PROPN
fnp-3806	1824	9	w	w	PROPN
fnp-3806	1824	10	,	,	PUNCT
fnp-3806	1824	11	et	et	PROPN
fnp-3806	1824	12	al	al	PROPN
fnp-3806	1824	13	.	.	PROPN
fnp-3806	1825	1	novel	novel	PROPN
fnp-3806	1825	2	tau	tau	PROPN
fnp-3806	1825	3	filament	filament	NOUN
fnp-3806	1825	4	fold	fold	NOUN
fnp-3806	1825	5	in	in	ADP
fnp-3806	1825	6	chronic	chronic	ADJ
fnp-3806	1825	7	traumatic	traumatic	ADJ
fnp-3806	1825	8	encephalopathy	encephalopathy	NOUN
fnp-3806	1825	9	encloses	enclose	VERB
fnp-3806	1825	10	hydrophobic	hydrophobic	NOUN
fnp-3806	1825	11	molecules	molecule	NOUN
fnp-3806	1825	12	.	.	PUNCT
fnp-3806	1826	1	nature	nature	NOUN
fnp-3806	1826	2	2019;568:420	2019;568:420	NUM
fnp-3806	1826	3	-	-	SYM
fnp-3806	1826	4	423	423	NUM
fnp-3806	1826	5	.	.	PUNCT
fnp-3806	1826	6	https://doi.org/10.1038/s41586-019-1026-5	https://doi.org/10.1038/s41586-019-1026-5	PROPN
fnp-3806	1826	7	zhang	zhang	PROPN
fnp-3806	1826	8	w	w	PROPN
fnp-3806	1826	9	,	,	PUNCT
fnp-3806	1826	10	tarutani	tarutani	X
fnp-3806	1826	11	a	a	PRON
fnp-3806	1826	12	,	,	PUNCT
fnp-3806	1826	13	newell	newell	PROPN
fnp-3806	1826	14	kl	kl	PROPN
fnp-3806	1826	15	,	,	PUNCT
fnp-3806	1826	16	et	et	PROPN
fnp-3806	1826	17	al	al	PROPN
fnp-3806	1826	18	.	.	PROPN
fnp-3806	1826	19	novel	novel	PROPN
fnp-3806	1826	20	tau	tau	PROPN
fnp-3806	1826	21	filament	filament	NOUN
fnp-3806	1826	22	fold	fold	NOUN
fnp-3806	1826	23	in	in	ADP
fnp-3806	1826	24	corticobasal	corticobasal	NOUN
fnp-3806	1826	25	degeneration	degeneration	NOUN
fnp-3806	1826	26	.	.	PUNCT
fnp-3806	1827	1	nature	nature	NOUN
fnp-3806	1827	2	2020;580:283	2020;580:283	NUM
fnp-3806	1827	3	-	-	SYM
fnp-3806	1827	4	287	287	NUM
fnp-3806	1827	5	.	.	PUNCT
fnp-3806	1828	1	https://doi.org/10.1038/s41586-020-2043-0	https://doi.org/10.1038/s41586-020-2043-0	PROPN
fnp-3806	1828	2	arakhamia	arakhamia	PROPN
fnp-3806	1828	3	t	t	PROPN
fnp-3806	1828	4	,	,	PUNCT
fnp-3806	1828	5	lee	lee	PROPN
fnp-3806	1828	6	ce	ce	PROPN
fnp-3806	1828	7	,	,	PUNCT
fnp-3806	1828	8	carlomagno	carlomagno	PROPN
fnp-3806	1828	9	y	y	PROPN
fnp-3806	1828	10	,	,	PUNCT
fnp-3806	1828	11	et	et	PROPN
fnp-3806	1828	12	al	al	PROPN
fnp-3806	1828	13	.	.	PROPN
fnp-3806	1828	14	posttranslational	posttranslational	ADJ
fnp-3806	1828	15	modifications	modification	NOUN
fnp-3806	1828	16	mediate	mediate	VERB
fnp-3806	1828	17	the	the	DET
fnp-3806	1828	18	structural	structural	ADJ
fnp-3806	1828	19	diversity	diversity	NOUN
fnp-3806	1828	20	of	of	ADP
fnp-3806	1828	21	tauopathy	tauopathy	ADJ
fnp-3806	1828	22	strains	strain	NOUN
fnp-3806	1828	23	.	.	PUNCT
fnp-3806	1829	1	cell	cell	NOUN
fnp-3806	1829	2	2020;180:633	2020;180:633	NOUN
fnp-3806	1829	3	-	-	PUNCT
fnp-3806	1829	4	644.e12	644.e12	PROPN
fnp-3806	1829	5	.	.	PUNCT
fnp-3806	1830	1	https://doi.org/10.1016/j.cell.2020.01.027	https://doi.org/10.1016/j.cell.2020.01.027	PROPN
fnp-3806	1830	2	shi	shi	PROPN
fnp-3806	1830	3	y	y	PROPN
fnp-3806	1830	4	,	,	PUNCT
fnp-3806	1830	5	murzin	murzin	PROPN
fnp-3806	1830	6	ag	ag	PROPN
fnp-3806	1830	7	,	,	PUNCT
fnp-3806	1830	8	falcon	falcon	PROPN
fnp-3806	1830	9	b	b	PROPN
fnp-3806	1830	10	,	,	PUNCT
fnp-3806	1830	11	et	et	PROPN
fnp-3806	1830	12	al	al	PROPN
fnp-3806	1830	13	.	.	PUNCT
fnp-3806	1831	1	cryo	cryo	PROPN
fnp-3806	1831	2	-	-	PUNCT
fnp-3806	1831	3	em	em	PRON
fnp-3806	1831	4	structures	structure	NOUN
fnp-3806	1831	5	of	of	ADP
fnp-3806	1831	6	tau	tau	PROPN
fnp-3806	1831	7	filaments	filament	NOUN
fnp-3806	1831	8	from	from	ADP
fnp-3806	1831	9	alzheimer	alzheimer	PROPN
fnp-3806	1831	10	's	's	PART
fnp-3806	1831	11	disease	disease	NOUN
fnp-3806	1831	12	with	with	ADP
fnp-3806	1831	13	pet	pet	ADJ
fnp-3806	1831	14	ligand	ligand	NOUN
fnp-3806	1831	15	apn-1607	apn-1607	NOUN
fnp-3806	1831	16	.	.	PUNCT
fnp-3806	1832	1	acta	acta	PROPN
fnp-3806	1832	2	neuropathol	neuropathol	PROPN
fnp-3806	1832	3	2021;141	2021;141	NUM
fnp-3806	1832	4	:	:	PUNCT
fnp-3806	1832	5	697	697	NUM
fnp-3806	1832	6	-	-	SYM
fnp-3806	1832	7	708	708	NUM
fnp-3806	1832	8	.	.	PUNCT
fnp-3806	1833	1	https://doi.org/10.1007/s00401-021-02294-3	https://doi.org/10.1007/s00401-021-02294-3	NUM
fnp-3806	1833	2	shi	shi	PROPN
fnp-3806	1833	3	y	y	PROPN
fnp-3806	1833	4	,	,	PUNCT
fnp-3806	1833	5	zhang	zhang	PROPN
fnp-3806	1833	6	w	w	PROPN
fnp-3806	1833	7	,	,	PUNCT
fnp-3806	1833	8	yang	yang	PROPN
fnp-3806	1833	9	y	y	PROPN
fnp-3806	1833	10	,	,	PUNCT
fnp-3806	1833	11	et	et	PROPN
fnp-3806	1833	12	al	al	PROPN
fnp-3806	1833	13	.	.	PROPN
fnp-3806	1833	14	structure	structure	NOUN
fnp-3806	1833	15	-	-	PUNCT
fnp-3806	1833	16	based	base	VERB
fnp-3806	1833	17	classification	classification	NOUN
fnp-3806	1833	18	of	of	ADP
fnp-3806	1833	19	tauopathies	tauopathie	NOUN
fnp-3806	1833	20	.	.	PUNCT
fnp-3806	1834	1	nature	nature	NOUN
fnp-3806	1834	2	2021;598:359	2021;598:359	NUM
fnp-3806	1834	3	-	-	SYM
fnp-3806	1834	4	363	363	NUM
fnp-3806	1834	5	.	.	PUNCT
fnp-3806	1835	1	https://doi.org/10.1038/s41586-021-03911-7	https://doi.org/10.1038/s41586-021-03911-7	PROPN
fnp-3806	1836	1	smith	smith	PROPN
fnp-3806	1836	2	r	r	PROPN
fnp-3806	1836	3	,	,	PUNCT
fnp-3806	1836	4	strandberg	strandberg	PROPN
fnp-3806	1836	5	o	o	PROPN
fnp-3806	1836	6	,	,	PUNCT
fnp-3806	1836	7	mattsson	mattsson	PROPN
fnp-3806	1836	8	-	-	PUNCT
fnp-3806	1836	9	carlgren	carlgren	PROPN
fnp-3806	1836	10	n	n	CCONJ
fnp-3806	1836	11	,	,	PUNCT
fnp-3806	1836	12	et	et	PROPN
fnp-3806	1836	13	al	al	PROPN
fnp-3806	1836	14	.	.	PUNCT
fnp-3806	1837	1	the	the	DET
fnp-3806	1837	2	accumulation	accumulation	NOUN
fnp-3806	1837	3	rate	rate	NOUN
fnp-3806	1837	4	of	of	ADP
fnp-3806	1837	5	tau	tau	PROPN
fnp-3806	1837	6	aggregates	aggregate	NOUN
fnp-3806	1837	7	is	be	AUX
fnp-3806	1837	8	higher	high	ADJ
fnp-3806	1837	9	in	in	ADP
fnp-3806	1837	10	females	female	NOUN
fnp-3806	1837	11	and	and	CCONJ
fnp-3806	1837	12	younger	young	ADJ
fnp-3806	1837	13	amyloid	amyloid	NOUN
fnp-3806	1837	14	-	-	PUNCT
fnp-3806	1837	15	positive	positive	ADJ
fnp-3806	1837	16	subjects	subject	NOUN
fnp-3806	1837	17	.	.	PUNCT
fnp-3806	1838	1	brain	brain	NOUN
fnp-3806	1838	2	2020;143:3805	2020;143:3805	NUM
fnp-3806	1838	3	-	-	SYM
fnp-3806	1838	4	3815	3815	NUM
fnp-3806	1838	5	.	.	PUNCT
fnp-3806	1839	1	https://doi.org/10.1093/brain/awaa327	https://doi.org/10.1093/brain/awaa327	PROPN
fnp-3806	1839	2	davis	davis	PROPN
fnp-3806	1839	3	ej	ej	PROPN
fnp-3806	1839	4	,	,	PUNCT
fnp-3806	1839	5	carolinew	carolinew	PROPN
fnp-3806	1839	6	.	.	PUNCT
fnp-3806	1840	1	solsberg	solsberg	PROPN
fnp-3806	1840	2	cw	cw	NOUN
fnp-3806	1840	3	,	,	PUNCT
fnp-3806	1840	4	et	et	PROPN
fnp-3806	1840	5	al	al	PROPN
fnp-3806	1840	6	.	.	PUNCT
fnp-3806	1840	7	sex	sex	NOUN
fnp-3806	1840	8	-	-	PUNCT
fnp-3806	1840	9	specific	specific	ADJ
fnp-3806	1840	10	association	association	NOUN
fnp-3806	1840	11	of	of	ADP
fnp-3806	1840	12	the	the	DET
fnp-3806	1840	13	x	x	PUNCT
fnp-3806	1840	14	chromosome	chromosome	NOUN
fnp-3806	1840	15	with	with	ADP
fnp-3806	1840	16	cognitive	cognitive	ADJ
fnp-3806	1840	17	change	change	NOUN
fnp-3806	1840	18	and	and	CCONJ
fnp-3806	1840	19	tau	tau	PROPN
fnp-3806	1840	20	pathology	pathology	NOUN
fnp-3806	1840	21	in	in	ADP
fnp-3806	1840	22	aging	age	VERB
fnp-3806	1840	23	and	and	CCONJ
fnp-3806	1840	24	alzheimer	alzheimer	NOUN
fnp-3806	1840	25	disease	disease	NOUN
fnp-3806	1840	26	.	.	PUNCT
fnp-3806	1841	1	jama	jama	PROPN
fnp-3806	1841	2	neurol	neurol	PROPN
fnp-3806	1841	3	2021	2021	NUM
fnp-3806	1841	4	;	;	PUNCT
fnp-3806	1841	5	78:1249	78:1249	X
fnp-3806	1841	6	-	-	SYM
fnp-3806	1841	7	1254	1254	NUM
fnp-3806	1841	8	.	.	PUNCT
fnp-3806	1842	1	https://doi.org/10.1001/jamaneurol.2021.2806	https://doi.org/10.1001/jamaneurol.2021.2806	PROPN
fnp-3806	1842	2	meier	meier	PROPN
fnp-3806	1842	3	s	s	PROPN
fnp-3806	1842	4	,	,	PUNCT
fnp-3806	1842	5	bell	bell	PROPN
fnp-3806	1842	6	m	m	PROPN
fnp-3806	1842	7	,	,	PUNCT
fnp-3806	1842	8	lyons	lyons	PROPN
fnp-3806	1842	9	dn	dn	PROPN
fnp-3806	1842	10	,	,	PUNCT
fnp-3806	1842	11	et	et	PROPN
fnp-3806	1842	12	al	al	PROPN
fnp-3806	1842	13	.	.	PUNCT
fnp-3806	1842	14	identification	identification	NOUN
fnp-3806	1842	15	of	of	ADP
fnp-3806	1842	16	novel	novel	ADJ
fnp-3806	1842	17	tau	tau	NOUN
fnp-3806	1842	18	interactions	interaction	NOUN
fnp-3806	1842	19	with	with	ADP
fnp-3806	1842	20	endoplasmic	endoplasmic	ADJ
fnp-3806	1842	21	reticulum	reticulum	NOUN
fnp-3806	1842	22	proteins	protein	NOUN
fnp-3806	1842	23	in	in	ADP
fnp-3806	1842	24	alzheimer	alzheimer	PROPN
fnp-3806	1842	25	’s	’s	PART
fnp-3806	1842	26	disease	disease	NOUN
fnp-3806	1842	27	brain	brain	NOUN
fnp-3806	1842	28	.	.	PUNCT
fnp-3806	1843	1	j	j	PROPN
fnp-3806	1843	2	alzheimers	alzheimers	PROPN
fnp-3806	1843	3	dis	dis	PROPN
fnp-3806	1843	4	2015	2015	NUM
fnp-3806	1843	5	;	;	PUNCT
fnp-3806	1843	6	48	48	NUM
fnp-3806	1843	7	:	:	PUNCT
fnp-3806	1843	8	687	687	NUM
fnp-3806	1843	9	-	-	SYM
fnp-3806	1843	10	702	702	NUM
fnp-3806	1843	11	.	.	NOUN
fnp-3806	1843	12	https://doi.org/10.3233/jad-150298	https://doi.org/10.3233/jad-150298	X
fnp-3806	1843	13	ayyadevara	ayyadevara	PROPN
fnp-3806	1843	14	s	s	PROPN
fnp-3806	1843	15	,	,	PUNCT
fnp-3806	1843	16	balasubramaniam	balasubramaniam	PROPN
fnp-3806	1843	17	m	m	PROPN
fnp-3806	1843	18	,	,	PUNCT
fnp-3806	1843	19	parcon	parcon	PROPN
fnp-3806	1843	20	pa	pa	PROPN
fnp-3806	1843	21	,	,	PUNCT
fnp-3806	1843	22	et	et	PROPN
fnp-3806	1843	23	al	al	PROPN
fnp-3806	1843	24	.	.	PUNCT
fnp-3806	1843	25	proteins	protein	NOUN
fnp-3806	1843	26	that	that	PRON
fnp-3806	1843	27	mediate	mediate	VERB
fnp-3806	1843	28	protein	protein	NOUN
fnp-3806	1843	29	aggregation	aggregation	NOUN
fnp-3806	1843	30	and	and	CCONJ
fnp-3806	1843	31	cytotoxicity	cytotoxicity	NOUN
fnp-3806	1843	32	distinguish	distinguish	VERB
fnp-3806	1843	33	alzheimer	alzheimer	PROPN
fnp-3806	1843	34	’s	’s	PART
fnp-3806	1843	35	hippocampus	hippocampus	NOUN
fnp-3806	1843	36	from	from	ADP
fnp-3806	1843	37	normal	normal	ADJ
fnp-3806	1843	38	controls	control	NOUN
fnp-3806	1843	39	.	.	PUNCT
fnp-3806	1844	1	aging	age	VERB
fnp-3806	1844	2	cell	cell	NOUN
fnp-3806	1844	3	2016	2016	NUM
fnp-3806	1844	4	;	;	PUNCT
fnp-3806	1844	5	15	15	NUM
fnp-3806	1844	6	:	:	PUNCT
fnp-3806	1844	7	924	924	NUM
fnp-3806	1844	8	-	-	SYM
fnp-3806	1844	9	939	939	NUM
fnp-3806	1844	10	.	.	PUNCT
fnp-3806	1844	11	https://doi.org/10.1111/acel.12501	https://doi.org/10.1111/acel.12501	NOUN
fnp-3806	1844	12	drummond	drummond	PROPN
fnp-3806	1844	13	e	e	NOUN
fnp-3806	1844	14	,	,	PUNCT
fnp-3806	1844	15	pires	pire	VERB
fnp-3806	1844	16	g	g	PROPN
fnp-3806	1844	17	,	,	PUNCT
fnp-3806	1844	18	macmurray	macmurray	PROPN
fnp-3806	1844	19	c	c	PROPN
fnp-3806	1844	20	,	,	PUNCT
fnp-3806	1844	21	et	et	PROPN
fnp-3806	1844	22	al	al	PROPN
fnp-3806	1844	23	.	.	PROPN
fnp-3806	1845	1	phosphorylated	phosphorylate	VERB
fnp-3806	1845	2	tau	tau	PROPN
fnp-3806	1845	3	interactome	interactome	NOUN
fnp-3806	1845	4	in	in	ADP
fnp-3806	1845	5	the	the	DET
fnp-3806	1845	6	human	human	PROPN
fnp-3806	1845	7	alzheimer	alzheimer	PROPN
fnp-3806	1845	8	’s	’s	PART
fnp-3806	1845	9	disease	disease	NOUN
fnp-3806	1845	10	brain	brain	NOUN
fnp-3806	1845	11	.	.	PUNCT
fnp-3806	1846	1	brain	brain	NOUN
fnp-3806	1846	2	2020;143:2803	2020;143:2803	NUM
fnp-3806	1846	3	-	-	SYM
fnp-3806	1846	4	2817	2817	NUM
fnp-3806	1846	5	.	.	PUNCT
fnp-3806	1847	1	https://doi.org/10.1093/brain/awaa223	https://doi.org/10.1093/brain/awaa223	NOUN
fnp-3806	1848	1	van	van	PROPN
fnp-3806	1848	2	leeuwen	leeuwen	PROPN
fnp-3806	1848	3	fw	fw	PROPN
fnp-3806	1848	4	,	,	PUNCT
fnp-3806	1848	5	fischer	fischer	PROPN
fnp-3806	1848	6	df	df	PROPN
fnp-3806	1848	7	,	,	PUNCT
fnp-3806	1848	8	kamel	kamel	PROPN
fnp-3806	1848	9	d	d	PROPN
fnp-3806	1848	10	,	,	PUNCT
fnp-3806	1848	11	et	et	PROPN
fnp-3806	1848	12	al	al	PROPN
fnp-3806	1848	13	.	.	PUNCT
fnp-3806	1849	1	molecular	molecular	ADJ
fnp-3806	1849	2	misreading	misreading	NOUN
fnp-3806	1849	3	:	:	PUNCT
fnp-3806	1849	4	a	a	DET
fnp-3806	1849	5	new	new	ADJ
fnp-3806	1849	6	type	type	NOUN
fnp-3806	1849	7	of	of	ADP
fnp-3806	1849	8	transcript	transcript	NOUN
fnp-3806	1849	9	mutation	mutation	NOUN
fnp-3806	1849	10	expressed	express	VERB
fnp-3806	1849	11	during	during	ADP
fnp-3806	1849	12	aging	aging	NOUN
fnp-3806	1849	13	.	.	PUNCT
fnp-3806	1850	1	neurobiol	neurobiol	NOUN
fnp-3806	1850	2	aging	age	VERB
fnp-3806	1850	3	2000;21:879	2000;21:879	NUM
fnp-3806	1850	4	-	-	SYM
fnp-3806	1850	5	891	891	NUM
fnp-3806	1850	6	.	.	PUNCT
fnp-3806	1851	1	https://doi.org/10.1016/s0197-4580(00)00151-2	https://doi.org/10.1016/s0197-4580(00)00151-2	PROPN
fnp-3806	1851	2	van	van	PROPN
fnp-3806	1851	3	leeuwen	leeuwen	PROPN
fnp-3806	1851	4	fw	fw	PROPN
fnp-3806	1851	5	,	,	PUNCT
fnp-3806	1851	6	hol	hol	VERB
fnp-3806	1851	7	em	em	PRON
fnp-3806	1851	8	,	,	PUNCT
fnp-3806	1851	9	fischer	fischer	PROPN
fnp-3806	1851	10	df	df	PROPN
fnp-3806	1851	11	.	.	PUNCT
fnp-3806	1851	12	frameshift	frameshift	ADJ
fnp-3806	1851	13	proteins	protein	NOUN
fnp-3806	1851	14	in	in	ADP
fnp-3806	1851	15	alzheimer	alzheimer	PROPN
fnp-3806	1851	16	's	's	PART
fnp-3806	1851	17	disease	disease	NOUN
fnp-3806	1851	18	and	and	CCONJ
fnp-3806	1851	19	in	in	ADP
fnp-3806	1851	20	other	other	ADJ
fnp-3806	1851	21	conformational	conformational	ADJ
fnp-3806	1851	22	disorders	disorder	NOUN
fnp-3806	1851	23	:	:	PUNCT
fnp-3806	1851	24	time	time	NOUN
fnp-3806	1851	25	for	for	ADP
fnp-3806	1851	26	the	the	DET
fnp-3806	1851	27	ubiquitin	ubiquitin	ADJ
fnp-3806	1851	28	-	-	PUNCT
fnp-3806	1851	29	proteasome	proteasome	NOUN
fnp-3806	1851	30	system	system	NOUN
fnp-3806	1851	31	.	.	PUNCT
fnp-3806	1852	1	j	j	PROPN
fnp-3806	1852	2	alzheimers	alzheimers	PROPN
fnp-3806	1852	3	dis	dis	PROPN
fnp-3806	1852	4	2006;9:319	2006;9:319	PROPN
fnp-3806	1852	5	-	-	PUNCT
fnp-3806	1852	6	325	325	NUM
fnp-3806	1852	7	.	.	PUNCT
fnp-3806	1853	1	https://doi.org/10.3233/jad-2006-9s336	https://doi.org/10.3233/jad-2006-9s336	PROPN
fnp-3806	1853	2	vergara	vergara	PROPN
fnp-3806	1854	1	c	c	PROPN
fnp-3806	1854	2	,	,	PUNCT
fnp-3806	1854	3	ordonez	ordonez	PROPN
fnp-3806	1854	4	-	-	PUNCT
fnp-3806	1854	5	gutierrez	gutierrez	PROPN
fnp-3806	1854	6	l	l	PROPN
fnp-3806	1854	7	,	,	PUNCT
fnp-3806	1854	8	wandosell	wandosell	PROPN
fnp-3806	1854	9	f	f	X
fnp-3806	1854	10	,	,	PUNCT
fnp-3806	1854	11	et	et	PROPN
fnp-3806	1854	12	al	al	PROPN
fnp-3806	1854	13	.	.	PUNCT
fnp-3806	1854	14	role	role	NOUN
fnp-3806	1854	15	of	of	ADP
fnp-3806	1854	16	prp(c	prp(c	NOUN
fnp-3806	1854	17	)	)	PUNCT
fnp-3806	1854	18	expression	expression	NOUN
fnp-3806	1854	19	in	in	ADP
fnp-3806	1854	20	tau	tau	PROPN
fnp-3806	1854	21	protein	protein	NOUN
fnp-3806	1854	22	levels	level	NOUN
fnp-3806	1854	23	and	and	CCONJ
fnp-3806	1854	24	phosphorylation	phosphorylation	NOUN
fnp-3806	1854	25	in	in	ADP
fnp-3806	1854	26	alzheimer	alzheimer	PROPN
fnp-3806	1854	27	’s	’s	PART
fnp-3806	1854	28	disease	disease	NOUN
fnp-3806	1854	29	evolution	evolution	NOUN
fnp-3806	1854	30	.	.	PUNCT
fnp-3806	1855	1	mol	mol	ADP
fnp-3806	1855	2	neurobiol	neurobiol	NOUN
fnp-3806	1855	3	2015;51:1206	2015;51:1206	NUM
fnp-3806	1855	4	-	-	SYM
fnp-3806	1855	5	1220	1220	NUM
fnp-3806	1855	6	.	.	PUNCT
fnp-3806	1856	1	https://doi.org/10.1007/s12035-014-8793-7	https://doi.org/10.1007/s12035-014-8793-7	PROPN
fnp-3806	1856	2	chen	chen	PROPN
fnp-3806	1856	3	rj	rj	PROPN
fnp-3806	1856	4	,	,	PUNCT
fnp-3806	1856	5	chang	chang	PROPN
fnp-3806	1856	6	ww	ww	PROPN
fnp-3806	1856	7	,	,	PUNCT
fnp-3806	1856	8	lin	lin	PROPN
fnp-3806	1856	9	yc	yc	PROPN
fnp-3806	1856	10	,	,	PUNCT
fnp-3806	1856	11	et	et	PROPN
fnp-3806	1856	12	al	al	PROPN
fnp-3806	1856	13	.	.	PROPN
fnp-3806	1856	14	alzheimer	alzheimer	PROPN
fnp-3806	1856	15	’s	’s	PART
fnp-3806	1856	16	amyloid	amyloid	NOUN
fnp-3806	1856	17	-	-	PUNCT
fnp-3806	1856	18	beta	beta	NOUN
fnp-3806	1856	19	oligomers	oligomer	NOUN
fnp-3806	1856	20	rescue	rescue	VERB
fnp-3806	1856	21	cellular	cellular	ADJ
fnp-3806	1856	22	prion	prion	NOUN
fnp-3806	1856	23	protein	protein	NOUN
fnp-3806	1856	24	induced	induce	VERB
fnp-3806	1856	25	tau	tau	PROPN
fnp-3806	1856	26	reduction	reduction	NOUN
fnp-3806	1856	27	via	via	ADP
fnp-3806	1856	28	fyn	fyn	PROPN
fnp-3806	1856	29	pathways	pathway	NOUN
fnp-3806	1856	30	.	.	PUNCT
fnp-3806	1857	1	acs	acs	PROPN
fnp-3806	1857	2	chem	chem	NOUN
fnp-3806	1857	3	neurosci	neurosci	NOUN
fnp-3806	1857	4	2013	2013	NUM
fnp-3806	1857	5	;	;	PUNCT
fnp-3806	1857	6	4:1287	4:1287	NUM
fnp-3806	1857	7	-	-	SYM
fnp-3806	1857	8	1296	1296	NUM
fnp-3806	1857	9	.	.	PUNCT
fnp-3806	1858	1	https://doi.org/10.1021/cn400085q	https://doi.org/10.1021/cn400085q	PROPN
fnp-3806	1858	2	schmitz	schmitz	PROPN
fnp-3806	1858	3	m	m	PROPN
fnp-3806	1858	4	,	,	PUNCT
fnp-3806	1858	5	wulf	wulf	PROPN
fnp-3806	1858	6	k	k	PROPN
fnp-3806	1858	7	,	,	PUNCT
fnp-3806	1858	8	signore	signore	PROPN
fnp-3806	1858	9	sc	sc	PROPN
fnp-3806	1858	10	,	,	PUNCT
fnp-3806	1858	11	et	et	PROPN
fnp-3806	1858	12	al	al	PROPN
fnp-3806	1858	13	.	.	PROPN
fnp-3806	1858	14	impact	impact	NOUN
fnp-3806	1858	15	of	of	ADP
fnp-3806	1858	16	the	the	DET
fnp-3806	1858	17	cellular	cellular	ADJ
fnp-3806	1858	18	prion	prion	NOUN
fnp-3806	1858	19	protein	protein	NOUN
fnp-3806	1858	20	on	on	ADP
fnp-3806	1858	21	amyloid	amyloid	NOUN
fnp-3806	1858	22	-	-	PUNCT
fnp-3806	1858	23	beta	beta	NOUN
fnp-3806	1858	24	and	and	CCONJ
fnp-3806	1858	25	3po	3po	ADJ
fnp-3806	1858	26	-	-	PUNCT
fnp-3806	1858	27	tau	tau	NOUN
fnp-3806	1858	28	processing	processing	NOUN
fnp-3806	1858	29	.	.	PUNCT
fnp-3806	1859	1	j	j	PROPN
fnp-3806	1859	2	alzheimers	alzheimers	PROPN
fnp-3806	1859	3	dis	dis	PROPN
fnp-3806	1859	4	2014;38	2014;38	NUM
fnp-3806	1859	5	:	:	PUNCT
fnp-3806	1859	6	551	551	NUM
fnp-3806	1859	7	-	-	SYM
fnp-3806	1859	8	565	565	NUM
fnp-3806	1859	9	.	.	PUNCT
fnp-3806	1860	1	https://doi.org/10.3233/jad-130566	https://doi.org/10.3233/jad-130566	ADJ
fnp-3806	1860	2	lidón	lidón	ADJ
fnp-3806	1860	3	l	l	NOUN
fnp-3806	1860	4	,	,	PUNCT
fnp-3806	1860	5	vergara	vergara	PROPN
fnp-3806	1860	6	c	c	PROPN
fnp-3806	1860	7	,	,	PUNCT
fnp-3806	1860	8	ferrer	ferrer	PROPN
fnp-3806	1860	9	i	i	PROPN
fnp-3806	1860	10	,	,	PUNCT
fnp-3806	1860	11	et	et	PROPN
fnp-3806	1860	12	al	al	PROPN
fnp-3806	1860	13	.	.	PUNCT
fnp-3806	1861	1	tau	tau	PROPN
fnp-3806	1861	2	protein	protein	NOUN
fnp-3806	1861	3	as	as	ADP
fnp-3806	1861	4	a	a	DET
fnp-3806	1861	5	new	new	ADJ
fnp-3806	1861	6	regulator	regulator	NOUN
fnp-3806	1861	7	of	of	ADP
fnp-3806	1861	8	cellular	cellular	ADJ
fnp-3806	1861	9	prion	prion	NOUN
fnp-3806	1861	10	protein	protein	NOUN
fnp-3806	1861	11	transcription	transcription	NOUN
fnp-3806	1861	12	.	.	PUNCT
fnp-3806	1862	1	mol	mol	ADP
fnp-3806	1862	2	neurobiol	neurobiol	NOUN
fnp-3806	1862	3	2020;57:4170	2020;57:4170	NUM
fnp-3806	1862	4	-	-	SYM
fnp-3806	1862	5	4186	4186	NUM
fnp-3806	1862	6	.	.	PUNCT
fnp-3806	1863	1	https://doi.org/10.1007/s12035-020-02025-x	https://doi.org/10.1007/s12035-020-02025-x	PROPN
fnp-3806	1863	2	lidón	lidón	ADJ
fnp-3806	1863	3	l	l	NOUN
fnp-3806	1863	4	,	,	PUNCT
fnp-3806	1863	5	llaó	llaó	NOUN
fnp-3806	1863	6	-	-	PUNCT
fnp-3806	1863	7	hierro	hierro	PROPN
fnp-3806	1863	8	l	l	PROPN
fnp-3806	1863	9	,	,	PUNCT
fnp-3806	1863	10	nuvolone	nuvolone	PROPN
fnp-3806	1863	11	m	m	PROPN
fnp-3806	1863	12	,	,	PUNCT
fnp-3806	1863	13	et	et	PROPN
fnp-3806	1863	14	al	al	PROPN
fnp-3806	1863	15	.	.	PUNCT
fnp-3806	1864	1	tau	tau	PROPN
fnp-3806	1864	2	exon	exon	VERB
fnp-3806	1864	3	10	10	NUM
fnp-3806	1864	4	inclusion	inclusion	NOUN
fnp-3806	1864	5	by	by	ADP
fnp-3806	1864	6	prpc	prpc	NOUN
fnp-3806	1864	7	through	through	ADP
fnp-3806	1864	8	down	down	ADV
fnp-3806	1864	9	-	-	PUNCT
fnp-3806	1864	10	regulating	regulate	VERB
fnp-3806	1864	11	gsk3β	gsk3β	PROPN
fnp-3806	1864	12	activity	activity	NOUN
fnp-3806	1864	13	.	.	PUNCT
fnp-3806	1865	1	int	int	PROPN
fnp-3806	1865	2	j	j	PROPN
fnp-3806	1865	3	mol	mol	ADP
fnp-3806	1865	4	sci	sci	PROPN
fnp-3806	1865	5	2021;22	2021;22	NUM
fnp-3806	1865	6	:	:	PUNCT
fnp-3806	1865	7	5370	5370	NUM
fnp-3806	1865	8	.	.	PUNCT
fnp-3806	1866	1	https://doi.org/10.3390/ijms22105370	https://doi.org/10.3390/ijms22105370	NOUN
fnp-3806	1866	2	gavín	gavín	VERB
fnp-3806	1866	3	r	r	NOUN
fnp-3806	1866	4	,	,	PUNCT
fnp-3806	1866	5	lidón	lidón	ADJ
fnp-3806	1866	6	l	l	NOUN
fnp-3806	1866	7	,	,	PUNCT
fnp-3806	1866	8	ferrer	ferrer	PROPN
fnp-3806	1866	9	i	i	PROPN
fnp-3806	1866	10	,	,	PUNCT
fnp-3806	1866	11	del	del	PROPN
fnp-3806	1866	12	río	río	PROPN
fnp-3806	1866	13	ja	ja	PROPN
fnp-3806	1866	14	.	.	PUNCT
fnp-3806	1867	1	the	the	DET
fnp-3806	1867	2	quest	quest	NOUN
fnp-3806	1867	3	for	for	ADP
fnp-3806	1867	4	cellular	cellular	ADJ
fnp-3806	1867	5	prion	prion	NOUN
fnp-3806	1867	6	protein	protein	NOUN
fnp-3806	1867	7	functions	function	NOUN
fnp-3806	1867	8	in	in	ADP
fnp-3806	1867	9	the	the	DET
fnp-3806	1867	10	aged	aged	ADJ
fnp-3806	1867	11	and	and	CCONJ
fnp-3806	1867	12	neurodegenerating	neurodegenerate	VERB
fnp-3806	1867	13	brain	brain	NOUN
fnp-3806	1867	14	.	.	PUNCT
fnp-3806	1868	1	cells	cell	NOUN
fnp-3806	1868	2	2020;9:591	2020;9:591	VERB
fnp-3806	1868	3	.	.	PUNCT
fnp-3806	1869	1	https://doi.org/10.3390/cells9030591	https://doi.org/10.3390/cells9030591	PROPN
fnp-3806	1869	2	goate	goate	PROPN
fnp-3806	1869	3	a	a	DET
fnp-3806	1869	4	,	,	PUNCT
fnp-3806	1869	5	chartier	chartier	NOUN
fnp-3806	1869	6	-	-	PUNCT
fnp-3806	1869	7	harlin	harlin	PROPN
fnp-3806	1869	8	mc	mc	PROPN
fnp-3806	1869	9	,	,	PUNCT
fnp-3806	1869	10	mullan	mullan	PROPN
fnp-3806	1869	11	m	m	PROPN
fnp-3806	1869	12	,	,	PUNCT
fnp-3806	1869	13	et	et	PROPN
fnp-3806	1869	14	al	al	PROPN
fnp-3806	1869	15	.	.	PROPN
fnp-3806	1869	16	segregation	segregation	NOUN
fnp-3806	1869	17	of	of	ADP
fnp-3806	1869	18	a	a	DET
fnp-3806	1869	19	missense	missense	NOUN
fnp-3806	1869	20	mutation	mutation	NOUN
fnp-3806	1869	21	in	in	ADP
fnp-3806	1869	22	the	the	DET
fnp-3806	1869	23	amyloid	amyloid	NOUN
fnp-3806	1869	24	precursor	precursor	NOUN
fnp-3806	1869	25	protein	protein	NOUN
fnp-3806	1869	26	gene	gene	NOUN
fnp-3806	1869	27	with	with	ADP
fnp-3806	1869	28	familial	familial	ADJ
fnp-3806	1869	29	alzheimer	alzheimer	NOUN
fnp-3806	1869	30	's	's	PART
fnp-3806	1869	31	disease	disease	NOUN
fnp-3806	1869	32	.	.	PUNCT
fnp-3806	1870	1	nature	nature	NOUN
fnp-3806	1870	2	1991;349:704	1991;349:704	NUM
fnp-3806	1870	3	-	-	SYM
fnp-3806	1870	4	706	706	NUM
fnp-3806	1870	5	.	.	PUNCT
fnp-3806	1870	6	https://doi.org/10.1038/349704a0	https://doi.org/10.1038/349704a0	NOUN
fnp-3806	1870	7	chartier	chartier	NOUN
fnp-3806	1870	8	-	-	PUNCT
fnp-3806	1870	9	harlin	harlin	PROPN
fnp-3806	1870	10	mc	mc	PROPN
fnp-3806	1870	11	,	,	PUNCT
fnp-3806	1870	12	crawford	crawford	PROPN
fnp-3806	1870	13	f	f	PROPN
fnp-3806	1870	14	,	,	PUNCT
fnp-3806	1870	15	houlden	houlden	ADJ
fnp-3806	1870	16	h	h	NOUN
fnp-3806	1870	17	,	,	PUNCT
fnp-3806	1870	18	et	et	PROPN
fnp-3806	1870	19	al	al	PROPN
fnp-3806	1870	20	.	.	PUNCT
fnp-3806	1871	1	early	early	ADJ
fnp-3806	1871	2	-	-	PUNCT
fnp-3806	1871	3	onset	onset	NOUN
fnp-3806	1871	4	alzheimer	alzheimer	NOUN
fnp-3806	1871	5	's	's	PART
fnp-3806	1871	6	disease	disease	NOUN
fnp-3806	1871	7	caused	cause	VERB
fnp-3806	1871	8	by	by	ADP
fnp-3806	1871	9	mutations	mutation	NOUN
fnp-3806	1871	10	at	at	ADP
fnp-3806	1871	11	codon	codon	NOUN
fnp-3806	1871	12	717	717	NUM
fnp-3806	1871	13	of	of	ADP
fnp-3806	1871	14	the	the	DET
fnp-3806	1871	15	β	β	NOUN
fnp-3806	1871	16	-	-	ADJ
fnp-3806	1871	17	amyloid	amyloid	ADJ
fnp-3806	1871	18	precursor	precursor	NOUN
fnp-3806	1871	19	protein	protein	NOUN
fnp-3806	1871	20	gene	gene	NOUN
fnp-3806	1871	21	.	.	PUNCT
fnp-3806	1872	1	nature	nature	NOUN
fnp-3806	1872	2	1991	1991	NUM
fnp-3806	1872	3	;	;	PUNCT
fnp-3806	1872	4	353	353	NUM
fnp-3806	1872	5	:	:	PUNCT
fnp-3806	1872	6	844	844	NUM
fnp-3806	1872	7	-	-	SYM
fnp-3806	1872	8	846	846	NUM
fnp-3806	1872	9	.	.	PUNCT
fnp-3806	1873	1	https://doi.org/10.1038/353844a0	https://doi.org/10.1038/353844a0	PROPN
fnp-3806	1873	2	murrell	murrell	PROPN
fnp-3806	1873	3	j	j	PROPN
fnp-3806	1873	4	,	,	PUNCT
fnp-3806	1873	5	farlow	farlow	PROPN
fnp-3806	1873	6	m	m	PROPN
fnp-3806	1873	7	,	,	PUNCT
fnp-3806	1873	8	ghetti	ghetti	PROPN
fnp-3806	1873	9	b	b	PROPN
fnp-3806	1873	10	,	,	PUNCT
fnp-3806	1873	11	et	et	PROPN
fnp-3806	1873	12	al	al	PROPN
fnp-3806	1873	13	.	.	PUNCT
fnp-3806	1874	1	a	a	DET
fnp-3806	1874	2	mutation	mutation	NOUN
fnp-3806	1874	3	in	in	ADP
fnp-3806	1874	4	the	the	DET
fnp-3806	1874	5	amyloid	amyloid	NOUN
fnp-3806	1874	6	precursor	precursor	NOUN
fnp-3806	1874	7	protein	protein	NOUN
fnp-3806	1874	8	associated	associate	VERB
fnp-3806	1874	9	with	with	ADP
fnp-3806	1874	10	hereditary	hereditary	ADJ
fnp-3806	1874	11	alzheimer	alzheimer	PROPN
fnp-3806	1874	12	's	's	PART
fnp-3806	1874	13	disease	disease	NOUN
fnp-3806	1874	14	.	.	PUNCT
fnp-3806	1875	1	science	science	NOUN
fnp-3806	1875	2	1991;254:97	1991;254:97	NUM
fnp-3806	1875	3	-	-	SYM
fnp-3806	1875	4	99	99	NUM
fnp-3806	1875	5	.	.	PUNCT
fnp-3806	1876	1	https://doi.org/10.1126/science.1925564	https://doi.org/10.1126/science.1925564	ADJ
fnp-3806	1876	2	levy	levy	NOUN
fnp-3806	1876	3	-	-	PUNCT
fnp-3806	1876	4	lahad	lahad	NOUN
fnp-3806	1876	5	e	e	PROPN
fnp-3806	1876	6	,	,	PUNCT
fnp-3806	1876	7	wasco	wasco	PROPN
fnp-3806	1876	8	w	w	PROPN
fnp-3806	1876	9	,	,	PUNCT
fnp-3806	1876	10	poorkaj	poorkaj	VERB
fnp-3806	1876	11	p	p	NOUN
fnp-3806	1876	12	,	,	PUNCT
fnp-3806	1876	13	et	et	PROPN
fnp-3806	1876	14	al	al	PROPN
fnp-3806	1876	15	.	.	PUNCT
fnp-3806	1876	16	candidate	candidate	NOUN
fnp-3806	1876	17	gene	gene	NOUN
fnp-3806	1876	18	for	for	ADP
fnp-3806	1876	19	the	the	DET
fnp-3806	1876	20	chromosome	chromosome	NOUN
fnp-3806	1876	21	1	1	NUM
fnp-3806	1876	22	familial	familial	ADJ
fnp-3806	1876	23	alzheimer	alzheimer	NOUN
fnp-3806	1876	24	's	's	PART
fnp-3806	1876	25	disease	disease	NOUN
fnp-3806	1876	26	locus	locus	NOUN
fnp-3806	1876	27	.	.	PUNCT
fnp-3806	1877	1	science	science	NOUN
fnp-3806	1877	2	1995	1995	NUM
fnp-3806	1877	3	;	;	PUNCT
fnp-3806	1877	4	18;269:973	18;269:973	NUM
fnp-3806	1877	5	-	-	SYM
fnp-3806	1877	6	977	977	NUM
fnp-3806	1877	7	.	.	PUNCT
fnp-3806	1878	1	https://doi.org/10.1126/science.7638622	https://doi.org/10.1126/science.7638622	NUM
fnp-3806	1878	2	sherrington	sherrington	PROPN
fnp-3806	1878	3	r	r	NOUN
fnp-3806	1878	4	,	,	PUNCT
fnp-3806	1878	5	rogaev	rogaev	NOUN
fnp-3806	1878	6	ei	ei	PROPN
fnp-3806	1878	7	,	,	PUNCT
fnp-3806	1878	8	liang	liang	PROPN
fnp-3806	1878	9	y	y	PROPN
fnp-3806	1878	10	,	,	PUNCT
fnp-3806	1878	11	et	et	PROPN
fnp-3806	1878	12	al	al	PROPN
fnp-3806	1878	13	.	.	PUNCT
fnp-3806	1878	14	cloning	cloning	NOUN
fnp-3806	1878	15	of	of	ADP
fnp-3806	1878	16	a	a	DET
fnp-3806	1878	17	gene	gene	NOUN
fnp-3806	1878	18	bearing	bear	VERB
fnp-3806	1878	19	missense	missense	NOUN
fnp-3806	1878	20	mutations	mutation	NOUN
fnp-3806	1878	21	in	in	ADP
fnp-3806	1878	22	early	early	ADJ
fnp-3806	1878	23	-	-	PUNCT
fnp-3806	1878	24	onset	onset	NOUN
fnp-3806	1878	25	familial	familial	ADJ
fnp-3806	1878	26	alzheimer	alzheimer	NOUN
fnp-3806	1878	27	's	's	PART
fnp-3806	1878	28	disease	disease	NOUN
fnp-3806	1878	29	.	.	PUNCT
fnp-3806	1879	1	nature	nature	NOUN
fnp-3806	1879	2	1995;375:754	1995;375:754	NUM
fnp-3806	1879	3	-	-	SYM
fnp-3806	1879	4	760	760	NUM
fnp-3806	1879	5	.	.	PUNCT
fnp-3806	1880	1	https://doi.org/10.1038/375754a0	https://doi.org/10.1038/375754a0	PRON
fnp-3806	1880	2	rogaev	rogaev	PROPN
fnp-3806	1880	3	ei	ei	NOUN
fnp-3806	1880	4	,	,	PUNCT
fnp-3806	1880	5	sherrington	sherrington	NOUN
fnp-3806	1880	6	r	r	NOUN
fnp-3806	1880	7	,	,	PUNCT
fnp-3806	1880	8	rogaeva	rogaeva	NOUN
fnp-3806	1880	9	ea	ea	PROPN
fnp-3806	1880	10	,	,	PUNCT
fnp-3806	1880	11	et	et	PROPN
fnp-3806	1880	12	al	al	PROPN
fnp-3806	1880	13	.	.	PROPN
fnp-3806	1881	1	familial	familial	ADJ
fnp-3806	1881	2	alzheimer	alzheimer	PROPN
fnp-3806	1881	3	's	's	PART
fnp-3806	1881	4	disease	disease	NOUN
fnp-3806	1881	5	in	in	ADP
fnp-3806	1881	6	kindreds	kindred	NOUN
fnp-3806	1881	7	with	with	ADP
fnp-3806	1881	8	missense	missense	NOUN
fnp-3806	1881	9	mutations	mutation	NOUN
fnp-3806	1881	10	in	in	ADP
fnp-3806	1881	11	a	a	DET
fnp-3806	1881	12	gene	gene	NOUN
fnp-3806	1881	13	on	on	ADP
fnp-3806	1881	14	chromosome	chromosome	NOUN
fnp-3806	1881	15	1	1	NUM
fnp-3806	1881	16	related	relate	VERB
fnp-3806	1881	17	to	to	ADP
fnp-3806	1881	18	the	the	DET
fnp-3806	1881	19	alzheimer	alzheimer	PROPN
fnp-3806	1881	20	's	's	PART
fnp-3806	1881	21	disease	disease	NOUN
fnp-3806	1881	22	type	type	VERB
fnp-3806	1881	23	3	3	NUM
fnp-3806	1881	24	gene	gene	NOUN
fnp-3806	1881	25	.	.	PUNCT
fnp-3806	1882	1	nature	nature	NOUN
fnp-3806	1882	2	1995;376:775	1995;376:775	NUM
fnp-3806	1882	3	-	-	SYM
fnp-3806	1882	4	778	778	NUM
fnp-3806	1882	5	.	.	PUNCT
fnp-3806	1883	1	https://doi.org/10.1038/376775a0	https://doi.org/10.1038/376775a0	PROPN
fnp-3806	1883	2	goedert	goedert	PROPN
fnp-3806	1883	3	m	m	PROPN
fnp-3806	1883	4	,	,	PUNCT
fnp-3806	1883	5	spillantini	spillantini	PROPN
fnp-3806	1883	6	mg	mg	PROPN
fnp-3806	1883	7	.	.	PUNCT
fnp-3806	1884	1	a	a	DET
fnp-3806	1884	2	century	century	NOUN
fnp-3806	1884	3	of	of	ADP
fnp-3806	1884	4	alzheimer	alzheimer	PROPN
fnp-3806	1884	5	’s	’s	PART
fnp-3806	1884	6	disease	disease	NOUN
fnp-3806	1884	7	.	.	PUNCT
fnp-3806	1885	1	science	science	NOUN
fnp-3806	1885	2	2006	2006	NUM
fnp-3806	1885	3	;	;	PUNCT
fnp-3806	1885	4	314	314	NUM
fnp-3806	1885	5	:	:	PUNCT
fnp-3806	1885	6	777	777	NUM
fnp-3806	1885	7	-	-	SYM
fnp-3806	1885	8	781	781	NUM
fnp-3806	1885	9	.	.	PUNCT
fnp-3806	1885	10	https://doi.org/10.1126/science.1132814	https://doi.org/10.1126/science.1132814	PROPN
fnp-3806	1885	11	bertram	bertram	PROPN
fnp-3806	1885	12	l	l	PROPN
fnp-3806	1885	13	,	,	PUNCT
fnp-3806	1885	14	tanzi	tanzi	PROPN
fnp-3806	1885	15	re	re	PROPN
fnp-3806	1885	16	.	.	PUNCT
fnp-3806	1886	1	genetics	genetics	PROPN
fnp-3806	1886	2	of	of	ADP
fnp-3806	1886	3	alzheimer	alzheimer	PROPN
fnp-3806	1886	4	’s	’s	PART
fnp-3806	1886	5	disease	disease	NOUN
fnp-3806	1886	6	.	.	PUNCT
fnp-3806	1887	1	in	in	ADP
fnp-3806	1887	2	:	:	PUNCT
fnp-3806	1887	3	dickson	dickson	PROPN
fnp-3806	1887	4	dw	dw	PROPN
fnp-3806	1887	5	,	,	PUNCT
fnp-3806	1887	6	weller	weller	PROPN
fnp-3806	1887	7	ro	ro	X
fnp-3806	1887	8	(	(	PUNCT
fnp-3806	1887	9	eds	eds	PROPN
fnp-3806	1887	10	)	)	PUNCT
fnp-3806	1887	11	the	the	DET
fnp-3806	1887	12	molecular	molecular	ADJ
fnp-3806	1887	13	pathology	pathology	NOUN
fnp-3806	1887	14	of	of	ADP
fnp-3806	1887	15	dementias	dementia	NOUN
fnp-3806	1887	16	and	and	CCONJ
fnp-3806	1887	17	movement	movement	NOUN
fnp-3806	1887	18	disorders	disorder	NOUN
fnp-3806	1887	19	,	,	PUNCT
fnp-3806	1887	20	2nd	2nd	ADJ
fnp-3806	1887	21	edn	edn	NOUN
fnp-3806	1887	22	.	.	PUNCT
fnp-3806	1888	1	wiley	wiley	PROPN
fnp-3806	1888	2	-	-	PUNCT
fnp-3806	1888	3	blackwell	blackwell	PROPN
fnp-3806	1888	4	,	,	PUNCT
fnp-3806	1888	5	oxford	oxford	PROPN
fnp-3806	1888	6	,	,	PUNCT
fnp-3806	1888	7	2011	2011	NUM
fnp-3806	1888	8	;	;	PUNCT
fnp-3806	1888	9	pp	pp	PROPN
fnp-3806	1888	10	51	51	NUM
fnp-3806	1888	11	-	-	SYM
fnp-3806	1888	12	61	61	NUM
fnp-3806	1888	13	hardy	hardy	ADJ
fnp-3806	1888	14	ja	ja	PROPN
fnp-3806	1888	15	,	,	PUNCT
fnp-3806	1888	16	higgins	higgins	PROPN
fnp-3806	1888	17	ga	ga	PROPN
fnp-3806	1888	18	.	.	PROPN
fnp-3806	1888	19	alzheimer	alzheimer	PROPN
fnp-3806	1888	20	’s	’s	PART
fnp-3806	1888	21	disease	disease	NOUN
fnp-3806	1888	22	:	:	PUNCT
fnp-3806	1888	23	the	the	DET
fnp-3806	1888	24	amyloid	amyloid	NOUN
fnp-3806	1888	25	cascade	cascade	NOUN
fnp-3806	1888	26	hypothesis	hypothesis	NOUN
fnp-3806	1888	27	.	.	PUNCT
fnp-3806	1889	1	science	science	NOUN
fnp-3806	1889	2	1992	1992	NUM
fnp-3806	1889	3	;	;	PUNCT
fnp-3806	1889	4	256:184	256:184	VERB
fnp-3806	1889	5	-	-	SYM
fnp-3806	1889	6	185	185	NUM
fnp-3806	1889	7	.	.	PUNCT
fnp-3806	1890	1	https://doi.org/10.1126/science.1566067	https://doi.org/10.1126/science.1566067	PROPN
fnp-3806	1890	2	lewis	lewis	PROPN
fnp-3806	1890	3	j	j	PROPN
fnp-3806	1890	4	,	,	PUNCT
fnp-3806	1890	5	dickson	dickson	PROPN
fnp-3806	1890	6	dw	dw	PROPN
fnp-3806	1890	7	,	,	PUNCT
fnp-3806	1890	8	lin	lin	PROPN
fnp-3806	1890	9	wl	wl	PROPN
fnp-3806	1890	10	,	,	PUNCT
fnp-3806	1890	11	et	et	PROPN
fnp-3806	1890	12	al	al	PROPN
fnp-3806	1890	13	.	.	PROPN
fnp-3806	1891	1	enhanced	enhance	VERB
fnp-3806	1891	2	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1891	3	degeneration	degeneration	NOUN
fnp-3806	1891	4	in	in	ADP
fnp-3806	1891	5	transgenic	transgenic	NOUN
fnp-3806	1891	6	mice	mouse	NOUN
fnp-3806	1891	7	expressing	express	VERB
fnp-3806	1891	8	mutant	mutant	NOUN
fnp-3806	1891	9	tau	tau	PROPN
fnp-3806	1891	10	and	and	CCONJ
fnp-3806	1891	11	app	app	PROPN
fnp-3806	1891	12	.	.	PROPN
fnp-3806	1892	1	science	science	PROPN
fnp-3806	1892	2	2001;293:1487	2001;293:1487	NUM
fnp-3806	1892	3	-	-	SYM
fnp-3806	1892	4	1491	1491	NUM
fnp-3806	1892	5	.	.	PUNCT
fnp-3806	1893	1	https://doi.org/10.1126/science.1058189	https://doi.org/10.1126/science.1058189	X
fnp-3806	1893	2	ribé	ribé	NOUN
fnp-3806	1893	3	em	em	PRON
fnp-3806	1893	4	,	,	PUNCT
fnp-3806	1893	5	pérez	pérez	NOUN
fnp-3806	1893	6	m	m	PROPN
fnp-3806	1893	7	,	,	PUNCT
fnp-3806	1893	8	puig	puig	PROPN
fnp-3806	1893	9	b	b	PROPN
fnp-3806	1893	10	,	,	PUNCT
fnp-3806	1893	11	et	et	PROPN
fnp-3806	1893	12	al	al	PROPN
fnp-3806	1893	13	.	.	PROPN
fnp-3806	1893	14	accelerated	accelerate	VERB
fnp-3806	1893	15	amyloid	amyloid	NOUN
fnp-3806	1893	16	deposition	deposition	NOUN
fnp-3806	1893	17	,	,	PUNCT
fnp-3806	1893	18	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1893	19	degeneration	degeneration	NOUN
fnp-3806	1893	20	,	,	PUNCT
fnp-3806	1893	21	and	and	CCONJ
fnp-3806	1893	22	neuronal	neuronal	ADJ
fnp-3806	1893	23	loss	loss	NOUN
fnp-3806	1893	24	in	in	ADP
fnp-3806	1893	25	double	double	ADJ
fnp-3806	1893	26	mutant	mutant	ADJ
fnp-3806	1893	27	app	app	PROPN
fnp-3806	1893	28	/	/	SYM
fnp-3806	1893	29	tau	tau	PROPN
fnp-3806	1893	30	transgenic	transgenic	NOUN
fnp-3806	1893	31	mice	mouse	NOUN
fnp-3806	1893	32	.	.	PUNCT
fnp-3806	1894	1	neurobiol	neurobiol	PROPN
fnp-3806	1894	2	dis	dis	PROPN
fnp-3806	1894	3	2005;20:814	2005;20:814	PROPN
fnp-3806	1894	4	-	-	PUNCT
fnp-3806	1894	5	822	822	NUM
fnp-3806	1894	6	.	.	PUNCT
fnp-3806	1895	1	https://doi.org/10.1016/j.nbd.2005.05.027	https://doi.org/10.1016/j.nbd.2005.05.027	PROPN
fnp-3806	1895	2	samura	samura	PROPN
fnp-3806	1895	3	e	e	PROPN
fnp-3806	1895	4	,	,	PUNCT
fnp-3806	1895	5	shoji	shoji	PROPN
fnp-3806	1895	6	m	m	PROPN
fnp-3806	1895	7	,	,	PUNCT
fnp-3806	1895	8	kawarabayashi	kawarabayashi	PROPN
fnp-3806	1895	9	t	t	PROPN
fnp-3806	1895	10	,	,	PUNCT
fnp-3806	1895	11	et	et	PROPN
fnp-3806	1895	12	al	al	PROPN
fnp-3806	1895	13	.	.	PROPN
fnp-3806	1896	1	enhanced	enhance	VERB
fnp-3806	1896	2	accumulation	accumulation	NOUN
fnp-3806	1896	3	of	of	ADP
fnp-3806	1896	4	tau	tau	PROPN
fnp-3806	1896	5	in	in	ADP
fnp-3806	1896	6	doubly	doubly	ADV
fnp-3806	1896	7	transgenic	transgenic	NOUN
fnp-3806	1896	8	mice	mouse	NOUN
fnp-3806	1896	9	expressing	express	VERB
fnp-3806	1896	10	mutant	mutant	NOUN
fnp-3806	1896	11	betaapp	betaapp	NOUN
fnp-3806	1896	12	and	and	CCONJ
fnp-3806	1896	13	presenilin-1	presenilin-1	PROPN
fnp-3806	1896	14	.	.	PROPN
fnp-3806	1896	15	brain	brain	NOUN
fnp-3806	1896	16	res	re	NOUN
fnp-3806	1896	17	2006;1094:192	2006;1094:192	PROPN
fnp-3806	1896	18	-	-	SYM
fnp-3806	1896	19	199	199	NUM
fnp-3806	1896	20	.	.	PUNCT
fnp-3806	1897	1	https://doi.org/10.1016/j.brainres.2005.12.134	https://doi.org/10.1016/j.brainres.2005.12.134	PROPN
fnp-3806	1897	2	bennett	bennett	PROPN
fnp-3806	1897	3	re	re	PROPN
fnp-3806	1897	4	,	,	PUNCT
fnp-3806	1897	5	devos	devos	PROPN
fnp-3806	1897	6	sl	sl	PROPN
fnp-3806	1897	7	,	,	PUNCT
fnp-3806	1897	8	dujardin	dujardin	PROPN
fnp-3806	1897	9	s	s	PROPN
fnp-3806	1897	10	,	,	PUNCT
fnp-3806	1897	11	et	et	PROPN
fnp-3806	1897	12	al	al	PROPN
fnp-3806	1897	13	.	.	PROPN
fnp-3806	1897	14	enhanced	enhance	VERB
fnp-3806	1897	15	tau	tau	PROPN
fnp-3806	1897	16	aggregation	aggregation	NOUN
fnp-3806	1897	17	in	in	ADP
fnp-3806	1897	18	the	the	DET
fnp-3806	1897	19	presence	presence	NOUN
fnp-3806	1897	20	of	of	ADP
fnp-3806	1897	21	amyloid	amyloid	NOUN
fnp-3806	1897	22	β	β	X
fnp-3806	1897	23	.	.	PUNCT
fnp-3806	1898	1	am	be	AUX
fnp-3806	1898	2	j	j	PROPN
fnp-3806	1898	3	pathol	pathol	NOUN
fnp-3806	1898	4	2017;187:1601	2017;187:1601	NUM
fnp-3806	1898	5	-	-	SYM
fnp-3806	1898	6	1612	1612	NUM
fnp-3806	1898	7	.	.	PUNCT
fnp-3806	1899	1	https://doi.org/10.1016/j.ajpath.2017.03.011	https://doi.org/10.1016/j.ajpath.2017.03.011	PROPN
fnp-3806	1899	2	hyman	hyman	PROPN
fnp-3806	1899	3	bt	bt	PROPN
fnp-3806	1899	4	,	,	PUNCT
fnp-3806	1899	5	west	west	PROPN
fnp-3806	1899	6	hl	hl	PROPN
fnp-3806	1899	7	,	,	PUNCT
fnp-3806	1899	8	rebeck	rebeck	VERB
fnp-3806	1899	9	gw	gw	PROPN
fnp-3806	1899	10	,	,	PUNCT
fnp-3806	1899	11	et	et	PROPN
fnp-3806	1899	12	al	al	PROPN
fnp-3806	1899	13	.	.	PUNCT
fnp-3806	1900	1	neuropathological	neuropathological	ADJ
fnp-3806	1900	2	changes	change	NOUN
fnp-3806	1900	3	in	in	ADP
fnp-3806	1900	4	down	down	ADP
fnp-3806	1900	5	's	's	PART
fnp-3806	1900	6	syndrome	syndrome	NOUN
fnp-3806	1900	7	hippocampal	hippocampal	ADJ
fnp-3806	1900	8	formation	formation	NOUN
fnp-3806	1900	9	.	.	PUNCT
fnp-3806	1901	1	effect	effect	NOUN
fnp-3806	1901	2	of	of	ADP
fnp-3806	1901	3	age	age	NOUN
fnp-3806	1901	4	and	and	CCONJ
fnp-3806	1901	5	apolipoprotein	apolipoprotein	NOUN
fnp-3806	1901	6	e	e	PROPN
fnp-3806	1901	7	genotype	genotype	NOUN
fnp-3806	1901	8	.	.	PUNCT
fnp-3806	1902	1	arch	arch	ADJ
fnp-3806	1902	2	neurol	neurol	NOUN
fnp-3806	1902	3	1995	1995	NUM
fnp-3806	1902	4	;	;	PUNCT
fnp-3806	1902	5	52:373	52:373	NUM
fnp-3806	1902	6	-	-	SYM
fnp-3806	1902	7	378	378	NUM
fnp-3806	1902	8	.	.	PUNCT
fnp-3806	1903	1	https://doi.org/10.1001/archneur.1995.00540280059019	https://doi.org/10.1001/archneur.1995.00540280059019	PROPN
fnp-3806	1903	2	hof	hof	PROPN
fnp-3806	1903	3	pr	pr	PROPN
fnp-3806	1903	4	,	,	PUNCT
fnp-3806	1903	5	bouras	bouras	NUM
fnp-3806	1903	6	c	c	NOUN
fnp-3806	1903	7	,	,	PUNCT
fnp-3806	1903	8	perl	perl	NOUN
fnp-3806	1903	9	dp	dp	NOUN
fnp-3806	1903	10	,	,	PUNCT
fnp-3806	1903	11	et	et	PROPN
fnp-3806	1903	12	al	al	PROPN
fnp-3806	1903	13	.	.	PUNCT
fnp-3806	1903	14	age	age	NOUN
fnp-3806	1903	15	-	-	PUNCT
fnp-3806	1903	16	related	relate	VERB
fnp-3806	1903	17	distribution	distribution	NOUN
fnp-3806	1903	18	of	of	ADP
fnp-3806	1903	19	neuropathological	neuropathological	ADJ
fnp-3806	1903	20	changes	change	NOUN
fnp-3806	1903	21	in	in	ADP
fnp-3806	1903	22	the	the	DET
fnp-3806	1903	23	cerebral	cerebral	ADJ
fnp-3806	1903	24	cortex	cortex	NOUN
fnp-3806	1903	25	of	of	ADP
fnp-3806	1903	26	patients	patient	NOUN
fnp-3806	1903	27	with	with	ADP
fnp-3806	1903	28	down	down	PROPN
fnp-3806	1903	29	's	's	PART
fnp-3806	1903	30	syndrome	syndrome	NOUN
fnp-3806	1903	31	.	.	PUNCT
fnp-3806	1904	1	arch	arch	ADJ
fnp-3806	1904	2	neurol	neurol	NOUN
fnp-3806	1904	3	1995	1995	NUM
fnp-3806	1904	4	;	;	PUNCT
fnp-3806	1904	5	52:379	52:379	NUM
fnp-3806	1904	6	-	-	SYM
fnp-3806	1904	7	391	391	NUM
fnp-3806	1904	8	.	.	PUNCT
fnp-3806	1905	1	https://doi.org/10.1001/archneur.1995.00540280065020	https://doi.org/10.1001/archneur.1995.00540280065020	PROPN
fnp-3806	1905	2	lemere	lemere	VERB
fnp-3806	1905	3	ca	ca	NOUN
fnp-3806	1905	4	,	,	PUNCT
fnp-3806	1905	5	blusztajn	blusztajn	PROPN
fnp-3806	1905	6	jk	jk	PROPN
fnp-3806	1905	7	,	,	PUNCT
fnp-3806	1905	8	yamaguchi	yamaguchi	PROPN
fnp-3806	1905	9	h	h	PROPN
fnp-3806	1905	10	,	,	PUNCT
fnp-3806	1905	11	et	et	PROPN
fnp-3806	1905	12	al	al	PROPN
fnp-3806	1905	13	.	.	PUNCT
fnp-3806	1905	14	sequence	sequence	NOUN
fnp-3806	1905	15	of	of	ADP
fnp-3806	1905	16	deposition	deposition	NOUN
fnp-3806	1905	17	of	of	ADP
fnp-3806	1905	18	heterogeneous	heterogeneous	ADJ
fnp-3806	1905	19	amyloid	amyloid	NOUN
fnp-3806	1905	20	beta	beta	NOUN
fnp-3806	1905	21	-	-	PUNCT
fnp-3806	1905	22	peptides	peptide	NOUN
fnp-3806	1905	23	and	and	CCONJ
fnp-3806	1905	24	apo	apo	PROPN
fnp-3806	1905	25	e	e	NOUN
fnp-3806	1905	26	in	in	ADP
fnp-3806	1905	27	down	down	ADP
fnp-3806	1905	28	syndrome	syndrome	NOUN
fnp-3806	1905	29	:	:	PUNCT
fnp-3806	1905	30	implications	implication	NOUN
fnp-3806	1905	31	for	for	ADP
fnp-3806	1905	32	initial	initial	ADJ
fnp-3806	1905	33	events	event	NOUN
fnp-3806	1905	34	in	in	ADP
fnp-3806	1905	35	amyloid	amyloid	NOUN
fnp-3806	1905	36	plaque	plaque	NOUN
fnp-3806	1905	37	formation	formation	NOUN
fnp-3806	1905	38	.	.	PUNCT
fnp-3806	1906	1	neurobiol	neurobiol	PROPN
fnp-3806	1906	2	dis	dis	PROPN
fnp-3806	1906	3	1996;3:16	1996;3:16	NOUN
fnp-3806	1906	4	-	-	PUNCT
fnp-3806	1906	5	32	32	NUM
fnp-3806	1906	6	.	.	PUNCT
fnp-3806	1907	1	https://doi.org/10.1006/nbdi.1996.0003	https://doi.org/10.1006/nbdi.1996.0003	ADJ
fnp-3806	1907	2	hartley	hartley	NOUN
fnp-3806	1907	3	d	d	PROPN
fnp-3806	1907	4	,	,	PUNCT
fnp-3806	1907	5	blumenthal	blumenthal	PROPN
fnp-3806	1907	6	t	t	PROPN
fnp-3806	1907	7	,	,	PUNCT
fnp-3806	1907	8	carrillo	carrillo	PROPN
fnp-3806	1907	9	m	m	PROPN
fnp-3806	1907	10	,	,	PUNCT
fnp-3806	1907	11	et	et	PROPN
fnp-3806	1907	12	al	al	PROPN
fnp-3806	1907	13	.	.	PROPN
fnp-3806	1907	14	down	down	ADP
fnp-3806	1907	15	syndrome	syndrome	PROPN
fnp-3806	1907	16	and	and	CCONJ
fnp-3806	1907	17	alzheimer	alzheimer	PROPN
fnp-3806	1907	18	’s	’s	PART
fnp-3806	1907	19	disease	disease	NOUN
fnp-3806	1907	20	:	:	PUNCT
fnp-3806	1907	21	common	common	ADJ
fnp-3806	1907	22	pathways	pathway	NOUN
fnp-3806	1907	23	,	,	PUNCT
fnp-3806	1907	24	common	common	ADJ
fnp-3806	1907	25	goals	goal	NOUN
fnp-3806	1907	26	.	.	PUNCT
fnp-3806	1908	1	alzheimers	alzheimers	PROPN
fnp-3806	1908	2	dement	dement	PROPN
fnp-3806	1908	3	2015;11:700	2015;11:700	PROPN
fnp-3806	1908	4	-	-	SYM
fnp-3806	1908	5	709	709	NUM
fnp-3806	1908	6	.	.	PUNCT
fnp-3806	1909	1	https://doi.org/10.1016/j.jalz.2014.10.007	https://doi.org/10.1016/j.jalz.2014.10.007	PROPN
fnp-3806	1909	2	tu	tu	PROPN
fnp-3806	1909	3	s	s	PROPN
fnp-3806	1909	4	,	,	PUNCT
fnp-3806	1909	5	okamoto	okamoto	PROPN
fnp-3806	1909	6	s	s	PROPN
fnp-3806	1909	7	,	,	PUNCT
fnp-3806	1909	8	lipton	lipton	PROPN
fnp-3806	1909	9	sa	sa	PROPN
fnp-3806	1909	10	,	,	PUNCT
fnp-3806	1909	11	et	et	PROPN
fnp-3806	1909	12	al	al	PROPN
fnp-3806	1909	13	.	.	PROPN
fnp-3806	1909	14	oligomeric	oligomeric	ADJ
fnp-3806	1909	15	aβ	aβ	NOUN
fnp-3806	1909	16	-	-	PUNCT
fnp-3806	1909	17	induced	induce	VERB
fnp-3806	1909	18	synaptic	synaptic	ADJ
fnp-3806	1909	19	dysfunction	dysfunction	NOUN
fnp-3806	1909	20	in	in	ADP
fnp-3806	1909	21	alzheimer	alzheimer	PROPN
fnp-3806	1909	22	's	's	PART
fnp-3806	1909	23	disease	disease	NOUN
fnp-3806	1909	24	.	.	PUNCT
fnp-3806	1910	1	mol	mol	ADP
fnp-3806	1910	2	neurodegener	neurodegener	PROPN
fnp-3806	1910	3	2014;9:48	2014;9:48	NOUN
fnp-3806	1910	4	.	.	PUNCT
fnp-3806	1911	1	https://doi.org/10.1186/1750-1326-9-48	https://doi.org/10.1186/1750-1326-9-48	NOUN
fnp-3806	1911	2	hillen	hillen	PROPN
fnp-3806	1911	3	h.	h.	PROPN
fnp-3806	1911	4	the	the	DET
fnp-3806	1911	5	beta	beta	NOUN
fnp-3806	1911	6	-	-	PUNCT
fnp-3806	1911	7	amyloid	amyloid	NOUN
fnp-3806	1911	8	dysfunction	dysfunction	NOUN
fnp-3806	1911	9	(	(	PUNCT
fnp-3806	1911	10	bad	bad	ADJ
fnp-3806	1911	11	)	)	PUNCT
fnp-3806	1911	12	hypothesis	hypothesis	NOUN
fnp-3806	1911	13	for	for	ADP
fnp-3806	1911	14	alzheimer	alzheimer	PROPN
fnp-3806	1911	15	’s	’s	PART
fnp-3806	1911	16	disease	disease	NOUN
fnp-3806	1911	17	.	.	PUNCT
fnp-3806	1912	1	front	front	ADJ
fnp-3806	1912	2	neurosci	neurosci	PROPN
fnp-3806	1912	3	2019	2019	NUM
fnp-3806	1912	4	;	;	PUNCT
fnp-3806	1912	5	13:1154	13:1154	NUM
fnp-3806	1912	6	.	.	PUNCT
fnp-3806	1913	1	https://doi.org/10.3389/fnins.2019.01154	https://doi.org/10.3389/fnins.2019.01154	NOUN
fnp-3806	1913	2	selkoe	selkoe	ADJ
fnp-3806	1913	3	dj	dj	NOUN
fnp-3806	1913	4	,	,	PUNCT
fnp-3806	1913	5	hardy	hardy	ADJ
fnp-3806	1913	6	j.	j.	PROPN
fnp-3806	1913	7	the	the	DET
fnp-3806	1913	8	amyloid	amyloid	NOUN
fnp-3806	1913	9	hypothesis	hypothesis	NOUN
fnp-3806	1913	10	of	of	ADP
fnp-3806	1913	11	alzheimer	alzheimer	PROPN
fnp-3806	1913	12	's	's	PART
fnp-3806	1913	13	disease	disease	NOUN
fnp-3806	1913	14	at	at	ADP
fnp-3806	1913	15	25	25	NUM
fnp-3806	1913	16	years	year	NOUN
fnp-3806	1913	17	.	.	PUNCT
fnp-3806	1914	1	embo	embo	NOUN
fnp-3806	1914	2	mol	mol	ADP
fnp-3806	1914	3	med	med	PROPN
fnp-3806	1914	4	2016	2016	NUM
fnp-3806	1914	5	;	;	PUNCT
fnp-3806	1914	6	8:595	8:595	NUM
fnp-3806	1914	7	-	-	SYM
fnp-3806	1914	8	608	608	NUM
fnp-3806	1914	9	.	.	PUNCT
fnp-3806	1915	1	https://doi.org/10.15252/emmm.201606210	https://doi.org/10.15252/emmm.201606210	PROPN
fnp-3806	1915	2	cline	cline	PROPN
fnp-3806	1915	3	en	en	PROPN
fnp-3806	1915	4	,	,	PUNCT
fnp-3806	1915	5	bicca	bicca	VERB
fnp-3806	1915	6	ma	ma	PROPN
fnp-3806	1915	7	,	,	PUNCT
fnp-3806	1915	8	viola	viola	PROPN
fnp-3806	1915	9	kl	kl	PROPN
fnp-3806	1915	10	,	,	PUNCT
fnp-3806	1915	11	et	et	PROPN
fnp-3806	1915	12	al	al	PROPN
fnp-3806	1915	13	.	.	PUNCT
fnp-3806	1916	1	the	the	DET
fnp-3806	1916	2	amyloid	amyloid	NOUN
fnp-3806	1916	3	-	-	PUNCT
fnp-3806	1916	4	β	β	X
fnp-3806	1916	5	oligomer	oligomer	ADJ
fnp-3806	1916	6	hypothesis	hypothesis	NOUN
fnp-3806	1916	7	:	:	PUNCT
fnp-3806	1916	8	beginning	begin	VERB
fnp-3806	1916	9	of	of	ADP
fnp-3806	1916	10	the	the	DET
fnp-3806	1916	11	third	third	ADJ
fnp-3806	1916	12	decade	decade	NOUN
fnp-3806	1916	13	.	.	PUNCT
fnp-3806	1917	1	j	j	PROPN
fnp-3806	1917	2	alzheimers	alzheimers	PROPN
fnp-3806	1917	3	dis	dis	PROPN
fnp-3806	1917	4	2018;64	2018;64	NUM
fnp-3806	1917	5	:	:	PUNCT
fnp-3806	1917	6	s567	s567	PROPN
fnp-3806	1917	7	-	-	PUNCT
fnp-3806	1917	8	s610	s610	PROPN
fnp-3806	1917	9	.	.	PUNCT
fnp-3806	1917	10	https://doi.org/10.3233/jad-179941	https://doi.org/10.3233/jad-179941	NUM
fnp-3806	1917	11	van	van	PROPN
fnp-3806	1917	12	helmond	helmond	PROPN
fnp-3806	1917	13	z	z	PROPN
fnp-3806	1917	14	,	,	PUNCT
fnp-3806	1917	15	scott	scott	PROPN
fnp-3806	1917	16	miners	miners	PROPN
fnp-3806	1917	17	j	j	PROPN
fnp-3806	1917	18	,	,	PUNCT
fnp-3806	1917	19	kehoe	kehoe	PROPN
fnp-3806	1917	20	pg	pg	PROPN
fnp-3806	1917	21	,	,	PUNCT
fnp-3806	1917	22	et	et	PROPN
fnp-3806	1917	23	al	al	PROPN
fnp-3806	1917	24	.	.	PROPN
fnp-3806	1918	1	higher	high	ADJ
fnp-3806	1918	2	soluble	soluble	ADJ
fnp-3806	1918	3	amyloid	amyloid	NOUN
fnp-3806	1918	4	beta	beta	ADJ
fnp-3806	1918	5	concentration	concentration	NOUN
fnp-3806	1918	6	in	in	ADP
fnp-3806	1918	7	frontal	frontal	ADJ
fnp-3806	1918	8	cortex	cortex	NOUN
fnp-3806	1918	9	of	of	ADP
fnp-3806	1918	10	young	young	ADJ
fnp-3806	1918	11	adults	adult	NOUN
fnp-3806	1918	12	than	than	ADP
fnp-3806	1918	13	in	in	ADP
fnp-3806	1918	14	normal	normal	ADJ
fnp-3806	1918	15	elderly	elderly	ADJ
fnp-3806	1918	16	or	or	CCONJ
fnp-3806	1918	17	alzheimer	alzheimer	NOUN
fnp-3806	1918	18	's	's	PART
fnp-3806	1918	19	disease	disease	NOUN
fnp-3806	1918	20	.	.	PUNCT
fnp-3806	1919	1	brain	brain	NOUN
fnp-3806	1919	2	pathol	pathol	NOUN
fnp-3806	1919	3	2010;20:787	2010;20:787	NUM
fnp-3806	1919	4	-	-	SYM
fnp-3806	1919	5	793	793	NUM
fnp-3806	1919	6	.	.	PUNCT
fnp-3806	1920	1	https://doi.org/10.1111/j.1750-3639.2010.00374.x	https://doi.org/10.1111/j.1750-3639.2010.00374.x	PROPN
fnp-3806	1920	2	miners	miner	NOUN
fnp-3806	1920	3	js	js	PROPN
fnp-3806	1920	4	,	,	PUNCT
fnp-3806	1920	5	jones	jones	PROPN
fnp-3806	1920	6	r	r	PROPN
fnp-3806	1920	7	,	,	PUNCT
fnp-3806	1920	8	love	love	NOUN
fnp-3806	1920	9	s.	s.	PROPN
fnp-3806	1920	10	differential	differential	PROPN
fnp-3806	1920	11	changes	change	NOUN
fnp-3806	1920	12	in	in	ADP
fnp-3806	1920	13	aβ42	aβ42	PROPN
fnp-3806	1920	14	and	and	CCONJ
fnp-3806	1920	15	aβ40	aβ40	PROPN
fnp-3806	1920	16	with	with	ADP
fnp-3806	1920	17	age	age	NOUN
fnp-3806	1920	18	.	.	PUNCT
fnp-3806	1921	1	j	j	PROPN
fnp-3806	1921	2	alzheimers	alzheimers	PROPN
fnp-3806	1921	3	dis	dis	PROPN
fnp-3806	1921	4	2014;40:727	2014;40:727	NUM
fnp-3806	1921	5	-	-	PUNCT
fnp-3806	1921	6	735	735	NUM
fnp-3806	1921	7	.	.	PUNCT
fnp-3806	1922	1	https://doi.org/10.3233/jad-132339	https://doi.org/10.3233/jad-132339	PROPN
fnp-3806	1922	2	van	van	PROPN
fnp-3806	1922	3	der	der	PROPN
fnp-3806	1922	4	kant	kant	PROPN
fnp-3806	1922	5	r	r	PROPN
fnp-3806	1922	6	,	,	PUNCT
fnp-3806	1922	7	goldstein	goldstein	PROPN
fnp-3806	1922	8	lsb	lsb	PROPN
fnp-3806	1922	9	,	,	PUNCT
fnp-3806	1922	10	ossenkoppele	ossenkoppele	PROPN
fnp-3806	1922	11	r.	r.	PROPN
fnp-3806	1922	12	amyloid	amyloid	PROPN
fnp-3806	1922	13	-	-	PUNCT
fnp-3806	1922	14	beta	beta	NOUN
fnp-3806	1922	15	-	-	PUNCT
fnp-3806	1922	16	independent	independent	ADJ
fnp-3806	1922	17	regulators	regulator	NOUN
fnp-3806	1922	18	of	of	ADP
fnp-3806	1922	19	tau	tau	PROPN
fnp-3806	1922	20	pathology	pathology	NOUN
fnp-3806	1922	21	in	in	ADP
fnp-3806	1922	22	alzheimer	alzheimer	PROPN
fnp-3806	1922	23	disease	disease	PROPN
fnp-3806	1922	24	.	.	PUNCT
fnp-3806	1923	1	nat	nat	PROPN
fnp-3806	1923	2	rev	rev	PROPN
fnp-3806	1923	3	neurosci	neurosci	PROPN
fnp-3806	1923	4	2020;21:21	2020;21:21	PROPN
fnp-3806	1923	5	-	-	SYM
fnp-3806	1923	6	35	35	NUM
fnp-3806	1923	7	.	.	PUNCT
fnp-3806	1924	1	https://doi.org/10.1038/s41583-019-0240-3	https://doi.org/10.1038/s41583-019-0240-3	PROPN
fnp-3806	1924	2	ochalek	ochalek	VERB
fnp-3806	1924	3	a	a	DET
fnp-3806	1924	4	,	,	PUNCT
fnp-3806	1924	5	mihalik	mihalik	PROPN
fnp-3806	1924	6	b	b	PROPN
fnp-3806	1924	7	,	,	PUNCT
fnp-3806	1924	8	avci	avci	PROPN
fnp-3806	1924	9	hx	hx	PROPN
fnp-3806	1924	10	,	,	PUNCT
fnp-3806	1924	11	et	et	PROPN
fnp-3806	1924	12	al	al	PROPN
fnp-3806	1924	13	.	.	PUNCT
fnp-3806	1925	1	neurons	neuron	NOUN
fnp-3806	1925	2	derived	derive	VERB
fnp-3806	1925	3	from	from	ADP
fnp-3806	1925	4	sporadic	sporadic	ADJ
fnp-3806	1925	5	alzheimer	alzheimer	PROPN
fnp-3806	1925	6	's	's	PART
fnp-3806	1925	7	disease	disease	NOUN
fnp-3806	1925	8	ipscs	ipsc	NOUN
fnp-3806	1925	9	reveal	reveal	VERB
fnp-3806	1925	10	elevated	elevate	VERB
fnp-3806	1925	11	tau	tau	PROPN
fnp-3806	1925	12	hyperphosphorylation	hyperphosphorylation	NOUN
fnp-3806	1925	13	,	,	PUNCT
fnp-3806	1925	14	increased	increase	VERB
fnp-3806	1925	15	amyloid	amyloid	NOUN
fnp-3806	1925	16	levels	level	NOUN
fnp-3806	1925	17	,	,	PUNCT
fnp-3806	1925	18	and	and	CCONJ
fnp-3806	1925	19	gsk3b	gsk3b	PROPN
fnp-3806	1925	20	activation	activation	NOUN
fnp-3806	1925	21	.	.	PUNCT
fnp-3806	1926	1	alzheimers	alzheimer	NOUN
fnp-3806	1926	2	res	re	VERB
fnp-3806	1926	3	ther	ther	ADJ
fnp-3806	1926	4	2017;9:90	2017;9:90	NOUN
fnp-3806	1926	5	.	.	PUNCT
fnp-3806	1927	1	https://doi.org/10.1186/s13195-017-0317-z	https://doi.org/10.1186/s13195-017-0317-z	PROPN
fnp-3806	1927	2	holton	holton	PROPN
fnp-3806	1927	3	jl	jl	PROPN
fnp-3806	1927	4	,	,	PUNCT
fnp-3806	1927	5	ghiso	ghiso	PROPN
fnp-3806	1927	6	j	j	PROPN
fnp-3806	1927	7	,	,	PUNCT
fnp-3806	1927	8	lashley	lashley	PROPN
fnp-3806	1927	9	t	t	PROPN
fnp-3806	1927	10	,	,	PUNCT
fnp-3806	1927	11	et	et	PROPN
fnp-3806	1927	12	al	al	PROPN
fnp-3806	1927	13	.	.	PUNCT
fnp-3806	1928	1	regional	regional	ADJ
fnp-3806	1928	2	distribution	distribution	NOUN
fnp-3806	1928	3	of	of	ADP
fnp-3806	1928	4	amyloid	amyloid	NOUN
fnp-3806	1928	5	-	-	PUNCT
fnp-3806	1928	6	bri	bri	NOUN
fnp-3806	1928	7	deposition	deposition	NOUN
fnp-3806	1928	8	and	and	CCONJ
fnp-3806	1928	9	its	its	PRON
fnp-3806	1928	10	association	association	NOUN
fnp-3806	1928	11	with	with	ADP
fnp-3806	1928	12	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1928	13	degeneration	degeneration	NOUN
fnp-3806	1928	14	in	in	ADP
fnp-3806	1928	15	familial	familial	ADJ
fnp-3806	1928	16	british	british	ADJ
fnp-3806	1928	17	dementia	dementia	NOUN
fnp-3806	1928	18	.	.	PUNCT
fnp-3806	1929	1	am	be	AUX
fnp-3806	1929	2	j	j	PROPN
fnp-3806	1929	3	pathol	pathol	NOUN
fnp-3806	1929	4	2001;158:515	2001;158:515	PROPN
fnp-3806	1929	5	-	-	SYM
fnp-3806	1929	6	526	526	NUM
fnp-3806	1929	7	.	.	PUNCT
fnp-3806	1930	1	https://doi.org/10.1016/s0002-9440(10)63993-4	https://doi.org/10.1016/s0002-9440(10)63993-4	PROPN
fnp-3806	1930	2	garringer	garringer	PROPN
fnp-3806	1930	3	hj	hj	PROPN
fnp-3806	1930	4	,	,	PUNCT
fnp-3806	1930	5	murrell	murrell	PROPN
fnp-3806	1930	6	j	j	PROPN
fnp-3806	1930	7	,	,	PUNCT
fnp-3806	1930	8	sammeta	sammeta	PROPN
fnp-3806	1930	9	n	n	CCONJ
fnp-3806	1930	10	,	,	PUNCT
fnp-3806	1930	11	et	et	PROPN
fnp-3806	1930	12	al	al	PROPN
fnp-3806	1930	13	.	.	PROPN
fnp-3806	1930	14	increased	increase	VERB
fnp-3806	1930	15	tau	tau	PROPN
fnp-3806	1930	16	phosphorylation	phosphorylation	NOUN
fnp-3806	1930	17	and	and	CCONJ
fnp-3806	1930	18	tau	tau	PROPN
fnp-3806	1930	19	truncation	truncation	NOUN
fnp-3806	1930	20	,	,	PUNCT
fnp-3806	1930	21	and	and	CCONJ
fnp-3806	1930	22	decreased	decrease	VERB
fnp-3806	1930	23	synaptophysin	synaptophysin	NOUN
fnp-3806	1930	24	levels	level	NOUN
fnp-3806	1930	25	in	in	ADP
fnp-3806	1930	26	mutant	mutant	ADJ
fnp-3806	1930	27	bri2	bri2	PROPN
fnp-3806	1930	28	/	/	SYM
fnp-3806	1930	29	tau	tau	PROPN
fnp-3806	1930	30	transgenic	transgenic	NOUN
fnp-3806	1930	31	mice	mouse	NOUN
fnp-3806	1930	32	.	.	PUNCT
fnp-3806	1931	1	plos	plos	PROPN
fnp-3806	1931	2	one	one	NUM
fnp-3806	1931	3	2013;8	2013;8	NUM
fnp-3806	1931	4	:	:	PUNCT
fnp-3806	1931	5	e56426	e56426	NUM
fnp-3806	1931	6	.	.	PUNCT
fnp-3806	1931	7	https://doi.org/10.1371/journal.pone.0056426	https://doi.org/10.1371/journal.pone.0056426	PROPN
fnp-3806	1931	8	alzualde	alzualde	PROPN
fnp-3806	1931	9	a	a	PRON
fnp-3806	1931	10	,	,	PUNCT
fnp-3806	1931	11	indakoetxea	indakoetxea	PROPN
fnp-3806	1931	12	b	b	NUM
fnp-3806	1931	13	,	,	PUNCT
fnp-3806	1931	14	ferrer	ferrer	PROPN
fnp-3806	1931	15	i	i	PROPN
fnp-3806	1931	16	,	,	PUNCT
fnp-3806	1931	17	et	et	PROPN
fnp-3806	1931	18	al	al	PROPN
fnp-3806	1931	19	.	.	PUNCT
fnp-3806	1932	1	a	a	DET
fnp-3806	1932	2	novel	novel	ADJ
fnp-3806	1932	3	prnp	prnp	NOUN
fnp-3806	1932	4	y218n	y218n	PROPN
fnp-3806	1932	5	mutation	mutation	NOUN
fnp-3806	1932	6	in	in	ADP
fnp-3806	1932	7	gerstmann	gerstmann	PROPN
fnp-3806	1932	8	–	–	PUNCT
fnp-3806	1932	9	sträussler	sträussler	NOUN
fnp-3806	1932	10	–	–	PUNCT
fnp-3806	1932	11	scheinker	scheinker	NOUN
fnp-3806	1932	12	disease	disease	NOUN
fnp-3806	1932	13	with	with	ADP
fnp-3806	1932	14	neurofibrillary	neurofibrillary	ADJ
fnp-3806	1932	15	degeneration	degeneration	NOUN
fnp-3806	1932	16	j	j	PROPN
fnp-3806	1932	17	neuropathol	neuropathol	PROPN
fnp-3806	1932	18	exp	exp	PROPN
fnp-3806	1932	19	neurol	neurol	PROPN
fnp-3806	1932	20	2010	2010	NUM
fnp-3806	1932	21	;	;	PUNCT
fnp-3806	1932	22	69	69	NUM
fnp-3806	1932	23	:	:	PUNCT
fnp-3806	1932	24	789	789	NUM
fnp-3806	1932	25	-	-	SYM
fnp-3806	1932	26	800	800	NUM
fnp-3806	1932	27	.	.	PUNCT
fnp-3806	1933	1	https://doi.org/10.1097/nen.0b013e3181e85737	https://doi.org/10.1097/nen.0b013e3181e85737	VERB
fnp-3806	1933	2	ghetti	ghetti	PROPN
fnp-3806	1933	3	b	b	PROPN
fnp-3806	1933	4	,	,	PUNCT
fnp-3806	1933	5	piccardo	piccardo	NOUN
fnp-3806	1933	6	p	p	X
fnp-3806	1933	7	,	,	PUNCT
fnp-3806	1933	8	zanusso	zanusso	X
fnp-3806	1933	9	g.	g.	NOUN
fnp-3806	1933	10	dominantly	dominantly	ADV
fnp-3806	1933	11	inherited	inherit	VERB
fnp-3806	1933	12	prion	prion	NOUN
fnp-3806	1933	13	protein	protein	NOUN
fnp-3806	1933	14	cerebral	cerebral	ADJ
fnp-3806	1933	15	amyloidoses	amyloidose	NOUN
fnp-3806	1933	16	a	a	DET
fnp-3806	1933	17	modern	modern	ADJ
fnp-3806	1933	18	view	view	NOUN
fnp-3806	1933	19	of	of	ADP
fnp-3806	1933	20	gerstmann	gerstmann	NOUN
fnp-3806	1933	21	-	-	PUNCT
fnp-3806	1933	22	sträussler	sträussler	NOUN
fnp-3806	1933	23	-	-	PUNCT
fnp-3806	1933	24	scheinker	scheinker	NOUN
fnp-3806	1933	25	.	.	PUNCT
fnp-3806	1934	1	handb	handb	PROPN
fnp-3806	1934	2	clin	clin	PROPN
fnp-3806	1934	3	neurol	neurol	PROPN
fnp-3806	1934	4	2018;153:243	2018;153:243	PROPN
fnp-3806	1934	5	-	-	SYM
fnp-3806	1934	6	269	269	NUM
fnp-3806	1934	7	.	.	PUNCT
fnp-3806	1935	1	https://doi.org/10.1016/b978-0-444-63945-5.00014-3	https://doi.org/10.1016/b978-0-444-63945-5.00014-3	NOUN
fnp-3806	1935	2	hallinan	hallinan	NOUN
fnp-3806	1935	3	gi	gi	NOUN
fnp-3806	1935	4	,	,	PUNCT
fnp-3806	1935	5	hoq	hoq	VERB
fnp-3806	1935	6	mr	mr	PROPN
fnp-3806	1935	7	,	,	PUNCT
fnp-3806	1935	8	ghosh	ghosh	PROPN
fnp-3806	1935	9	m	m	PROPN
fnp-3806	1935	10	,	,	PUNCT
fnp-3806	1935	11	et	et	PROPN
fnp-3806	1935	12	al	al	PROPN
fnp-3806	1935	13	.	.	PROPN
fnp-3806	1935	14	structure	structure	NOUN
fnp-3806	1935	15	of	of	ADP
fnp-3806	1935	16	tau	tau	PROPN
fnp-3806	1935	17	filaments	filament	NOUN
fnp-3806	1935	18	in	in	ADP
fnp-3806	1935	19	prion	prion	NOUN
fnp-3806	1935	20	protein	protein	NOUN
fnp-3806	1935	21	amyloidoses	amyloidose	NOUN
fnp-3806	1935	22	.	.	PUNCT
fnp-3806	1936	1	acta	acta	PROPN
fnp-3806	1936	2	neuropathol	neuropathol	PROPN
fnp-3806	1936	3	2021;142:227	2021;142:227	NUM
fnp-3806	1936	4	-	-	SYM
fnp-3806	1936	5	241	241	NUM
fnp-3806	1936	6	.	.	PUNCT
fnp-3806	1937	1	https://doi.org/10.1007/s00401-021-02336-w	https://doi.org/10.1007/s00401-021-02336-w	AUX
fnp-3806	1937	2	gibson	gibson	PROPN
fnp-3806	1937	3	g	g	PROPN
fnp-3806	1937	4	,	,	PUNCT
fnp-3806	1937	5	gunasekera	gunasekera	NOUN
fnp-3806	1937	6	n	n	CCONJ
fnp-3806	1937	7	,	,	PUNCT
fnp-3806	1937	8	lee	lee	PROPN
fnp-3806	1937	9	m	m	PROPN
fnp-3806	1937	10	,	,	PUNCT
fnp-3806	1937	11	et	et	PROPN
fnp-3806	1937	12	al	al	PROPN
fnp-3806	1937	13	.	.	PROPN
fnp-3806	1937	14	oligomerization	oligomerization	NOUN
fnp-3806	1937	15	and	and	CCONJ
fnp-3806	1937	16	neurotoxicity	neurotoxicity	NOUN
fnp-3806	1937	17	of	of	ADP
fnp-3806	1937	18	the	the	DET
fnp-3806	1937	19	amyloid	amyloid	NOUN
fnp-3806	1937	20	adan	adan	PROPN
fnp-3806	1937	21	peptide	peptide	PROPN
fnp-3806	1937	22	implicated	implicate	VERB
fnp-3806	1937	23	in	in	ADP
fnp-3806	1937	24	familial	familial	ADJ
fnp-3806	1937	25	danish	danish	ADJ
fnp-3806	1937	26	dementia	dementia	NOUN
fnp-3806	1937	27	.	.	PUNCT
fnp-3806	1938	1	j	j	PROPN
fnp-3806	1939	1	neurochem	neurochem	ADV
fnp-3806	1939	2	2004;88:281	2004;88:281	PROPN
fnp-3806	1939	3	-	-	SYM
fnp-3806	1939	4	290	290	NUM
fnp-3806	1939	5	.	.	PUNCT
fnp-3806	1940	1	https://doi.org/10.1046/j.1471-4159.2003.02134.x	https://doi.org/10.1046/j.1471-4159.2003.02134.x	NOUN
fnp-3806	1940	2	corder	corder	NOUN
fnp-3806	1940	3	eh	eh	INTJ
fnp-3806	1940	4	,	,	PUNCT
fnp-3806	1940	5	saunders	saunder	NOUN
fnp-3806	1940	6	am	be	AUX
fnp-3806	1940	7	,	,	PUNCT
fnp-3806	1940	8	strittmatter	strittmatter	NOUN
fnp-3806	1940	9	wj	wj	PROPN
fnp-3806	1940	10	,	,	PUNCT
fnp-3806	1940	11	et	et	PROPN
fnp-3806	1941	1	al	al	PROPN
fnp-3806	1941	2	.	.	PROPN
fnp-3806	1941	3	gene	gene	PROPN
fnp-3806	1941	4	dose	dose	PROPN
fnp-3806	1941	5	of	of	ADP
fnp-3806	1941	6	apolipoprotein	apolipoprotein	ADJ
fnp-3806	1941	7	e	e	PROPN
fnp-3806	1941	8	type	type	VERB
fnp-3806	1941	9	4	4	NUM
fnp-3806	1941	10	allele	allele	NOUN
fnp-3806	1941	11	and	and	CCONJ
fnp-3806	1941	12	the	the	DET
fnp-3806	1941	13	risk	risk	NOUN
fnp-3806	1941	14	of	of	ADP
fnp-3806	1941	15	alzheimer	alzheimer	PROPN
fnp-3806	1941	16	’s	’s	PART
fnp-3806	1941	17	disease	disease	NOUN
fnp-3806	1941	18	in	in	ADP
fnp-3806	1941	19	late	late	ADJ
fnp-3806	1941	20	onset	onset	NOUN
fnp-3806	1941	21	families	family	NOUN
fnp-3806	1941	22	.	.	PUNCT
fnp-3806	1942	1	science	science	NOUN
fnp-3806	1942	2	1993	1993	NUM
fnp-3806	1942	3	;	;	PUNCT
fnp-3806	1942	4	261	261	NUM
fnp-3806	1942	5	,	,	PUNCT
fnp-3806	1942	6	921–923	921–923	NUM
fnp-3806	1942	7	.	.	PUNCT
fnp-3806	1943	1	https://doi.org/10.1126/science.8346443	https://doi.org/10.1126/science.8346443	X
fnp-3806	1943	2	saunders	saunders	PROPN
fnp-3806	1943	3	am	be	AUX
fnp-3806	1943	4	,	,	PUNCT
fnp-3806	1943	5	strittmatter	strittmatter	NOUN
fnp-3806	1943	6	wj	wj	PROPN
fnp-3806	1943	7	,	,	PUNCT
fnp-3806	1943	8	schmechel	schmechel	PROPN
fnp-3806	1943	9	d	d	PROPN
fnp-3806	1943	10	,	,	PUNCT
fnp-3806	1943	11	et	et	PROPN
fnp-3806	1943	12	al	al	PROPN
fnp-3806	1943	13	.	.	PROPN
fnp-3806	1943	14	association	association	PROPN
fnp-3806	1943	15	of	of	ADP
fnp-3806	1943	16	apolipoprotein	apolipoprotein	ADJ
fnp-3806	1943	17	e	e	PROPN
fnp-3806	1943	18	allele	allele	PROPN
fnp-3806	1943	19	epsilon	epsilon	PROPN
fnp-3806	1943	20	4	4	NUM
fnp-3806	1943	21	with	with	ADP
fnp-3806	1943	22	late	late	ADJ
fnp-3806	1943	23	-	-	PUNCT
fnp-3806	1943	24	onset	onset	NOUN
fnp-3806	1943	25	familial	familial	ADJ
fnp-3806	1943	26	and	and	CCONJ
fnp-3806	1943	27	sporadic	sporadic	ADJ
fnp-3806	1943	28	alzheimer	alzheimer	PROPN
fnp-3806	1943	29	's	's	PART
fnp-3806	1943	30	disease	disease	NOUN
fnp-3806	1943	31	.	.	PUNCT
fnp-3806	1944	1	neurology	neurology	NOUN
fnp-3806	1944	2	1993	1993	NUM
fnp-3806	1944	3	;	;	PUNCT
fnp-3806	1944	4	43	43	NUM
fnp-3806	1944	5	:	:	SYM
fnp-3806	1944	6	1467	1467	NUM
fnp-3806	1944	7	-	-	SYM
fnp-3806	1944	8	1472	1472	NUM
fnp-3806	1944	9	.	.	PUNCT
fnp-3806	1945	1	https://doi.org/10.1212/wnl.43.8.1467	https://doi.org/10.1212/wnl.43.8.1467	PROPN
fnp-3806	1945	2	strittmatter	strittmatter	NOUN
fnp-3806	1945	3	wj	wj	PROPN
fnp-3806	1945	4	,	,	PUNCT
fnp-3806	1945	5	saunders	saunder	NOUN
fnp-3806	1945	6	am	be	AUX
fnp-3806	1945	7	,	,	PUNCT
fnp-3806	1945	8	schmechel	schmechel	PROPN
fnp-3806	1945	9	d	d	PROPN
fnp-3806	1945	10	,	,	PUNCT
fnp-3806	1945	11	et	et	PROPN
fnp-3806	1945	12	al	al	PROPN
fnp-3806	1945	13	.	.	PROPN
fnp-3806	1946	1	apolipoprotein	apolipoprotein	VERB
fnp-3806	1946	2	e	e	VERB
fnp-3806	1946	3	:	:	PUNCT
fnp-3806	1946	4	high	high	ADJ
fnp-3806	1946	5	-	-	PUNCT
fnp-3806	1946	6	avidity	avidity	NOUN
fnp-3806	1946	7	binding	bind	VERB
fnp-3806	1946	8	to	to	ADP
fnp-3806	1946	9	beta	beta	NOUN
fnp-3806	1946	10	-	-	PUNCT
fnp-3806	1946	11	amyloid	amyloid	NOUN
fnp-3806	1946	12	and	and	CCONJ
fnp-3806	1946	13	increased	increase	VERB
fnp-3806	1946	14	frequency	frequency	NOUN
fnp-3806	1946	15	of	of	ADP
fnp-3806	1946	16	type	type	NOUN
fnp-3806	1946	17	4	4	NUM
fnp-3806	1946	18	allele	allele	NOUN
fnp-3806	1946	19	in	in	ADP
fnp-3806	1946	20	late	late	ADJ
fnp-3806	1946	21	-	-	PUNCT
fnp-3806	1946	22	onset	onset	NOUN
fnp-3806	1946	23	familial	familial	ADJ
fnp-3806	1946	24	alzheimer	alzheimer	NOUN
fnp-3806	1946	25	disease	disease	NOUN
fnp-3806	1946	26	.	.	PUNCT
fnp-3806	1947	1	proc	proc	PROPN
fnp-3806	1947	2	natl	natl	PROPN
fnp-3806	1947	3	acad	acad	PROPN
fnp-3806	1947	4	sci	sci	PROPN
fnp-3806	1947	5	usa	usa	PROPN
fnp-3806	1947	6	1993	1993	NUM
fnp-3806	1947	7	;	;	PUNCT
fnp-3806	1947	8	90	90	NUM
fnp-3806	1947	9	:	:	SYM
fnp-3806	1947	10	1977	1977	NUM
fnp-3806	1947	11	-	-	SYM
fnp-3806	1947	12	1981	1981	NUM
fnp-3806	1947	13	.	.	PUNCT
fnp-3806	1948	1	https://doi.org/10.1073/pnas.90.5.1977	https://doi.org/10.1073/pnas.90.5.1977	PROPN
fnp-3806	1948	2	farrer	farrer	PROPN
fnp-3806	1948	3	la	la	PROPN
fnp-3806	1948	4	,	,	PUNCT
fnp-3806	1948	5	cupples	cupple	NOUN
fnp-3806	1948	6	la	la	PROPN
fnp-3806	1948	7	,	,	PUNCT
fnp-3806	1948	8	haines	haine	NOUN
fnp-3806	1948	9	jl	jl	PROPN
fnp-3806	1948	10	,	,	PUNCT
fnp-3806	1948	11	et	et	PROPN
fnp-3806	1948	12	al	al	PROPN
fnp-3806	1948	13	.	.	PUNCT
fnp-3806	1948	14	effects	effect	NOUN
fnp-3806	1948	15	of	of	ADP
fnp-3806	1948	16	age	age	NOUN
fnp-3806	1948	17	,	,	PUNCT
fnp-3806	1948	18	sex	sex	NOUN
fnp-3806	1948	19	,	,	PUNCT
fnp-3806	1948	20	and	and	CCONJ
fnp-3806	1948	21	ethnicity	ethnicity	NOUN
fnp-3806	1948	22	on	on	ADP
fnp-3806	1948	23	the	the	DET
fnp-3806	1948	24	association	association	NOUN
fnp-3806	1948	25	between	between	ADP
fnp-3806	1948	26	apolipoprotein	apolipoprotein	NOUN
fnp-3806	1948	27	e	e	PROPN
fnp-3806	1948	28	genotype	genotype	NOUN
fnp-3806	1948	29	and	and	CCONJ
fnp-3806	1948	30	alzheimer	alzheimer	PROPN
fnp-3806	1948	31	disease	disease	NOUN
fnp-3806	1948	32	.	.	PUNCT
fnp-3806	1949	1	a	a	DET
fnp-3806	1949	2	meta	meta	ADJ
fnp-3806	1949	3	-	-	PUNCT
fnp-3806	1949	4	analysis	analysis	NOUN
fnp-3806	1949	5	.	.	PUNCT
fnp-3806	1950	1	apoe	apoe	ADJ
fnp-3806	1950	2	and	and	CCONJ
fnp-3806	1950	3	alzheimer	alzheimer	PROPN
fnp-3806	1950	4	disease	disease	NOUN
fnp-3806	1950	5	meta	meta	VERB
fnp-3806	1950	6	analysis	analysis	NOUN
fnp-3806	1950	7	consortium	consortium	NOUN
fnp-3806	1950	8	.	.	PUNCT
fnp-3806	1951	1	jama	jama	PROPN
fnp-3806	1951	2	1997	1997	NUM
fnp-3806	1951	3	;	;	PUNCT
fnp-3806	1951	4	27	27	NUM
fnp-3806	1951	5	,	,	PUNCT
fnp-3806	1951	6	1349	1349	NUM
fnp-3806	1951	7	-	-	SYM
fnp-3806	1951	8	1356	1356	NUM
fnp-3806	1951	9	.	.	PUNCT
fnp-3806	1952	1	pmid	pmid	NOUN
fnp-3806	1952	2	:	:	PUNCT
fnp-3806	1952	3	9343467	9343467	NUM
fnp-3806	1952	4	harold	harold	PROPN
fnp-3806	1952	5	d	d	PROPN
fnp-3806	1952	6	,	,	PUNCT
fnp-3806	1952	7	abraham	abraham	PROPN
fnp-3806	1952	8	r	r	PROPN
fnp-3806	1952	9	,	,	PUNCT
fnp-3806	1952	10	hollingworth	hollingworth	NOUN
fnp-3806	1952	11	p	p	NOUN
fnp-3806	1952	12	,	,	PUNCT
fnp-3806	1952	13	et	et	PROPN
fnp-3806	1952	14	al	al	PROPN
fnp-3806	1952	15	.	.	PUNCT
fnp-3806	1952	16	genome	genome	NOUN
fnp-3806	1952	17	-	-	PUNCT
fnp-3806	1952	18	wide	wide	ADJ
fnp-3806	1952	19	association	association	NOUN
fnp-3806	1952	20	studies	study	NOUN
fnp-3806	1952	21	identifies	identify	VERB
fnp-3806	1952	22	variants	variant	NOUN
fnp-3806	1952	23	clu	clu	PROPN
fnp-3806	1952	24	and	and	CCONJ
fnp-3806	1952	25	picalm	picalm	NOUN
fnp-3806	1952	26	associated	associate	VERB
fnp-3806	1952	27	with	with	ADP
fnp-3806	1952	28	alzheimer	alzheimer	PROPN
fnp-3806	1952	29	’s	’s	PART
fnp-3806	1952	30	disease	disease	NOUN
fnp-3806	1952	31	.	.	PUNCT
fnp-3806	1953	1	nat	nat	PROPN
fnp-3806	1953	2	genet	genet	PROPN
fnp-3806	1953	3	2009;41:1088	2009;41:1088	PROPN
fnp-3806	1953	4	-	-	PUNCT
fnp-3806	1953	5	1093	1093	NUM
fnp-3806	1953	6	.	.	PUNCT
fnp-3806	1954	1	https://doi.org/10.1038/ng.440	https://doi.org/10.1038/ng.440	PROPN
fnp-3806	1954	2	lambert	lambert	PROPN
fnp-3806	1954	3	jc	jc	PROPN
fnp-3806	1954	4	,	,	PUNCT
fnp-3806	1954	5	heath	heath	PROPN
fnp-3806	1954	6	s	s	PROPN
fnp-3806	1954	7	,	,	PUNCT
fnp-3806	1954	8	even	even	ADV
fnp-3806	1954	9	g	g	PROPN
fnp-3806	1954	10	,	,	PUNCT
fnp-3806	1954	11	et	et	PROPN
fnp-3806	1954	12	al	al	PROPN
fnp-3806	1954	13	.	.	PUNCT
fnp-3806	1954	14	genome	genome	NOUN
fnp-3806	1954	15	-	-	PUNCT
fnp-3806	1954	16	wide	wide	ADJ
fnp-3806	1954	17	association	association	NOUN
fnp-3806	1954	18	study	study	NOUN
fnp-3806	1954	19	identifies	identify	VERB
fnp-3806	1954	20	variants	variant	NOUN
fnp-3806	1954	21	at	at	ADP
fnp-3806	1954	22	clu	clu	PROPN
fnp-3806	1954	23	and	and	CCONJ
fnp-3806	1954	24	cr1	cr1	PROPN
fnp-3806	1954	25	associated	associate	VERB
fnp-3806	1954	26	with	with	ADP
fnp-3806	1954	27	alzheimer	alzheimer	PROPN
fnp-3806	1954	28	's	's	PART
fnp-3806	1954	29	disease	disease	NOUN
fnp-3806	1954	30	.	.	PUNCT
fnp-3806	1955	1	nat	nat	PROPN
fnp-3806	1955	2	genet	genet	PROPN
fnp-3806	1955	3	2009;41:1094	2009;41:1094	PROPN
fnp-3806	1955	4	-	-	SYM
fnp-3806	1955	5	1099	1099	NUM
fnp-3806	1955	6	.	.	PUNCT
fnp-3806	1956	1	https://doi.org/10.1038/ng.439	https://doi.org/10.1038/ng.439	PROPN
fnp-3806	1956	2	seshadri	seshadri	PROPN
fnp-3806	1956	3	s	s	PROPN
fnp-3806	1956	4	,	,	PUNCT
fnp-3806	1956	5	fitzpatrick	fitzpatrick	PROPN
fnp-3806	1956	6	al	al	PROPN
fnp-3806	1956	7	,	,	PUNCT
fnp-3806	1956	8	ikram	ikram	PROPN
fnp-3806	1956	9	ma	ma	PROPN
fnp-3806	1956	10	,	,	PUNCT
fnp-3806	1956	11	et	et	PROPN
fnp-3806	1956	12	al	al	PROPN
fnp-3806	1956	13	.	.	PUNCT
fnp-3806	1956	14	genome	genome	NOUN
fnp-3806	1956	15	-	-	PUNCT
fnp-3806	1956	16	wide	wide	ADJ
fnp-3806	1956	17	analysis	analysis	NOUN
fnp-3806	1956	18	of	of	ADP
fnp-3806	1956	19	genetic	genetic	ADJ
fnp-3806	1956	20	loci	loci	NOUN
fnp-3806	1956	21	associated	associate	VERB
fnp-3806	1956	22	with	with	ADP
fnp-3806	1956	23	alzheiomer	alzheiomer	NOUN
fnp-3806	1956	24	’s	’s	PART
fnp-3806	1956	25	disease	disease	NOUN
fnp-3806	1956	26	.	.	PUNCT
fnp-3806	1957	1	jama	jama	PROPN
fnp-3806	1957	2	2010;303:1832	2010;303:1832	NUM
fnp-3806	1957	3	-	-	SYM
fnp-3806	1957	4	1840	1840	NUM
fnp-3806	1957	5	.	.	PUNCT
fnp-3806	1958	1	https://doi.org/10.1001/jama.2010.574	https://doi.org/10.1001/jama.2010.574	NOUN
fnp-3806	1958	2	jun	jun	PROPN
fnp-3806	1958	3	g	g	PROPN
fnp-3806	1958	4	,	,	PUNCT
fnp-3806	1958	5	naj	naj	PROPN
fnp-3806	1958	6	ac	ac	PROPN
fnp-3806	1958	7	,	,	PUNCT
fnp-3806	1958	8	beecham	beecham	PROPN
fnp-3806	1958	9	gw	gw	PROPN
fnp-3806	1958	10	,	,	PUNCT
fnp-3806	1958	11	et	et	PROPN
fnp-3806	1958	12	al	al	PROPN
fnp-3806	1958	13	.	.	PUNCT
fnp-3806	1959	1	meta	meta	ADJ
fnp-3806	1959	2	-	-	PUNCT
fnp-3806	1959	3	analysis	analysis	NOUN
fnp-3806	1959	4	confirms	confirm	VERB
fnp-3806	1959	5	cr1	cr1	PROPN
fnp-3806	1959	6	,	,	PUNCT
fnp-3806	1959	7	clu	clu	PROPN
fnp-3806	1959	8	,	,	PUNCT
fnp-3806	1959	9	and	and	CCONJ
fnp-3806	1959	10	picalm	picalm	NOUN
fnp-3806	1959	11	as	as	ADP
fnp-3806	1959	12	alzheimer	alzheimer	PROPN
fnp-3806	1959	13	disease	disease	NOUN
fnp-3806	1959	14	risk	risk	NOUN
fnp-3806	1959	15	loci	locus	NOUN
fnp-3806	1959	16	and	and	CCONJ
fnp-3806	1959	17	reveals	reveal	VERB
fnp-3806	1959	18	interactions	interaction	NOUN
fnp-3806	1959	19	with	with	ADP
fnp-3806	1959	20	apoe	apoe	ADJ
fnp-3806	1959	21	genotypes	genotype	NOUN
fnp-3806	1959	22	.	.	PUNCT
fnp-3806	1960	1	arch	arch	ADJ
fnp-3806	1960	2	neurol	neurol	NOUN
fnp-3806	1960	3	2010;67:1473	2010;67:1473	NUM
fnp-3806	1960	4	-	-	SYM
fnp-3806	1960	5	1484	1484	NUM
fnp-3806	1960	6	.	.	PUNCT
fnp-3806	1961	1	https://doi.org/10.1001/archneurol.2010.201	https://doi.org/10.1001/archneurol.2010.201	ADJ
fnp-3806	1961	2	jones	jones	PROPN
fnp-3806	1961	3	l	l	PROPN
fnp-3806	1961	4	,	,	PUNCT
fnp-3806	1961	5	holmans	holmans	PROPN
fnp-3806	1961	6	pa	pa	PROPN
fnp-3806	1961	7	,	,	PUNCT
fnp-3806	1961	8	hamshere	hamshere	NOUN
fnp-3806	1961	9	ml	ml	NOUN
fnp-3806	1961	10	,	,	PUNCT
fnp-3806	1961	11	et	et	PROPN
fnp-3806	1961	12	al	al	PROPN
fnp-3806	1961	13	.	.	PUNCT
fnp-3806	1962	1	genetic	genetic	ADJ
fnp-3806	1962	2	evidence	evidence	NOUN
fnp-3806	1962	3	implicates	implicate	VERB
fnp-3806	1962	4	the	the	DET
fnp-3806	1962	5	immune	immune	ADJ
fnp-3806	1962	6	system	system	NOUN
fnp-3806	1962	7	and	and	CCONJ
fnp-3806	1962	8	cholesterol	cholesterol	NOUN
fnp-3806	1962	9	metabolism	metabolism	NOUN
fnp-3806	1962	10	in	in	ADP
fnp-3806	1962	11	the	the	DET
fnp-3806	1962	12	aetiology	aetiology	NOUN
fnp-3806	1962	13	of	of	ADP
fnp-3806	1962	14	alzheimer	alzheimer	PROPN
fnp-3806	1962	15	’s	’s	PART
fnp-3806	1962	16	disease	disease	NOUN
fnp-3806	1962	17	.	.	PUNCT
fnp-3806	1963	1	plos	plos	PROPN
fnp-3806	1963	2	one	one	NUM
fnp-3806	1963	3	.	.	PUNCT
fnp-3806	1964	1	2010;5	2010;5	NUM
fnp-3806	1964	2	:	:	PUNCT
fnp-3806	1964	3	e13950	e13950	NOUN
fnp-3806	1964	4	.	.	PUNCT
fnp-3806	1964	5	https://doi.org/10.1371/journal.pone.0013950	https://doi.org/10.1371/journal.pone.0013950	PROPN
fnp-3806	1964	6	hollingworth	hollingworth	PROPN
fnp-3806	1964	7	p	p	NOUN
fnp-3806	1964	8	,	,	PUNCT
fnp-3806	1964	9	harold	harold	PROPN
fnp-3806	1964	10	d	d	PROPN
fnp-3806	1964	11	,	,	PUNCT
fnp-3806	1964	12	sims	sim	NOUN
fnp-3806	1964	13	r	r	NOUN
fnp-3806	1964	14	,	,	PUNCT
fnp-3806	1964	15	et	et	PROPN
fnp-3806	1964	16	al	al	PROPN
fnp-3806	1964	17	.	.	PROPN
fnp-3806	1964	18	common	common	ADJ
fnp-3806	1964	19	variants	variant	NOUN
fnp-3806	1964	20	at	at	ADP
fnp-3806	1964	21	abca7	abca7	PROPN
fnp-3806	1964	22	,	,	PUNCT
fnp-3806	1964	23	ms4a6a	ms4a6a	PROPN
fnp-3806	1964	24	/	/	SYM
fnp-3806	1964	25	ms4a4e	ms4a4e	PROPN
fnp-3806	1964	26	,	,	PUNCT
fnp-3806	1964	27	epha1	epha1	PROPN
fnp-3806	1964	28	,	,	PUNCT
fnp-3806	1964	29	cd33	cd33	PROPN
fnp-3806	1964	30	and	and	CCONJ
fnp-3806	1964	31	cd2ap	cd2ap	NOUN
fnp-3806	1964	32	are	be	AUX
fnp-3806	1964	33	associated	associate	VERB
fnp-3806	1964	34	with	with	ADP
fnp-3806	1964	35	alzheimer	alzheimer	PROPN
fnp-3806	1964	36	’s	’s	PART
fnp-3806	1964	37	disease	disease	NOUN
fnp-3806	1964	38	.	.	PUNCT
fnp-3806	1965	1	nat	nat	PROPN
fnp-3806	1965	2	genet	genet	PROPN
fnp-3806	1965	3	2011;43:429	2011;43:429	PROPN
fnp-3806	1965	4	-	-	SYM
fnp-3806	1965	5	435	435	NUM
fnp-3806	1965	6	.	.	PUNCT
fnp-3806	1966	1	https://doi.org/10.1038/ng.803	https://doi.org/10.1038/ng.803	PROPN
fnp-3806	1966	2	lambert	lambert	PROPN
fnp-3806	1966	3	jc	jc	PROPN
fnp-3806	1966	4	,	,	PUNCT
fnp-3806	1966	5	ibrahim	ibrahim	PROPN
fnp-3806	1966	6	-	-	PUNCT
fnp-3806	1966	7	verbaas	verbaas	PROPN
fnp-3806	1966	8	ca	ca	PROPN
fnp-3806	1966	9	,	,	PUNCT
fnp-3806	1966	10	harold	harold	PROPN
fnp-3806	1966	11	d	d	PROPN
fnp-3806	1966	12	,	,	PUNCT
fnp-3806	1966	13	et	et	PROPN
fnp-3806	1966	14	al	al	PROPN
fnp-3806	1966	15	.	.	PUNCT
fnp-3806	1967	1	meta	meta	VERB
fnp-3806	1967	2	-	-	PUNCT
fnp-3806	1967	3	analysis	analysis	NOUN
fnp-3806	1967	4	of	of	ADP
fnp-3806	1967	5	74,046	74,046	NUM
fnp-3806	1967	6	individuals	individual	NOUN
fnp-3806	1967	7	identifies	identify	VERB
fnp-3806	1967	8	11	11	NUM
fnp-3806	1967	9	new	new	ADJ
fnp-3806	1967	10	susceptibility	susceptibility	NOUN
fnp-3806	1967	11	loci	locus	NOUN
fnp-3806	1967	12	for	for	ADP
fnp-3806	1967	13	alzheimer	alzheimer	PROPN
fnp-3806	1967	14	's	's	PART
fnp-3806	1967	15	disease	disease	NOUN
fnp-3806	1967	16	.	.	PUNCT
fnp-3806	1968	1	nat	nat	PROPN
fnp-3806	1968	2	genet	genet	PROPN
fnp-3806	1968	3	2013	2013	NUM
fnp-3806	1968	4	;	;	PUNCT
fnp-3806	1968	5	45	45	NUM
fnp-3806	1968	6	:	:	SYM
fnp-3806	1968	7	1452	1452	NUM
fnp-3806	1968	8	-	-	SYM
fnp-3806	1968	9	1458	1458	NUM
fnp-3806	1968	10	.	.	PUNCT
fnp-3806	1969	1	https://doi.org/10.1038/ng.2802	https://doi.org/10.1038/ng.2802	ADP
fnp-3806	1969	2	naj	naj	X
fnp-3806	1969	3	ac	ac	PROPN
fnp-3806	1969	4	,	,	PUNCT
fnp-3806	1969	5	jun	jun	PROPN
fnp-3806	1969	6	g	g	PROPN
fnp-3806	1969	7	,	,	PUNCT
fnp-3806	1969	8	reitz	reitz	PROPN
fnp-3806	1969	9	c	c	AUX
fnp-3806	1969	10	,	,	PUNCT
fnp-3806	1969	11	et	et	PROPN
fnp-3806	1969	12	al	al	PROPN
fnp-3806	1969	13	.	.	PUNCT
fnp-3806	1969	14	effects	effect	NOUN
fnp-3806	1969	15	of	of	ADP
fnp-3806	1969	16	multiple	multiple	ADJ
fnp-3806	1969	17	genetic	genetic	ADJ
fnp-3806	1969	18	loci	loci	NOUN
fnp-3806	1969	19	on	on	ADP
fnp-3806	1969	20	age	age	NOUN
fnp-3806	1969	21	at	at	ADP
fnp-3806	1969	22	onset	onset	NOUN
fnp-3806	1969	23	in	in	ADP
fnp-3806	1969	24	late	late	ADJ
fnp-3806	1969	25	-	-	PUNCT
fnp-3806	1969	26	onset	onset	NOUN
fnp-3806	1969	27	alzheimer	alzheimer	NOUN
fnp-3806	1969	28	disease	disease	NOUN
fnp-3806	1969	29	:	:	PUNCT
fnp-3806	1969	30	a	a	DET
fnp-3806	1969	31	genome	genome	NOUN
fnp-3806	1969	32	-	-	PUNCT
fnp-3806	1969	33	wide	wide	ADJ
fnp-3806	1969	34	association	association	NOUN
fnp-3806	1969	35	study	study	NOUN
fnp-3806	1969	36	.	.	PUNCT
fnp-3806	1970	1	jama	jama	PROPN
fnp-3806	1970	2	neurol	neurol	PROPN
fnp-3806	1970	3	2014;71:1394	2014;71:1394	NUM
fnp-3806	1970	4	-	-	SYM
fnp-3806	1970	5	1404	1404	NUM
fnp-3806	1970	6	.	.	PUNCT
fnp-3806	1971	1	https://doi.org/10.1001/jamaneurol.2014.1491	https://doi.org/10.1001/jamaneurol.2014.1491	NOUN
fnp-3806	1971	2	sims	sim	NOUN
fnp-3806	1971	3	r	r	NOUN
fnp-3806	1971	4	,	,	PUNCT
fnp-3806	1971	5	van	van	PROPN
fnp-3806	1971	6	der	der	NOUN
fnp-3806	1971	7	lee	lee	PROPN
fnp-3806	1971	8	sj	sj	PROPN
fnp-3806	1971	9	,	,	PUNCT
fnp-3806	1971	10	naj	naj	PROPN
fnp-3806	1971	11	ac	ac	PROPN
fnp-3806	1971	12	et	et	PROPN
fnp-3806	1971	13	al	al	PROPN
fnp-3806	1971	14	.	.	PROPN
fnp-3806	1971	15	rare	rare	ADJ
fnp-3806	1971	16	coding	code	VERB
fnp-3806	1971	17	variants	variant	NOUN
fnp-3806	1971	18	in	in	ADP
fnp-3806	1971	19	plcg2	plcg2	NOUN
fnp-3806	1971	20	,	,	PUNCT
fnp-3806	1971	21	abi3	abi3	NOUN
fnp-3806	1971	22	,	,	PUNCT
fnp-3806	1971	23	and	and	CCONJ
fnp-3806	1971	24	trem2	trem2	NOUN
fnp-3806	1971	25	implicate	implicate	VERB
fnp-3806	1971	26	microglial	microglial	ADJ
fnp-3806	1971	27	-	-	PUNCT
fnp-3806	1971	28	mediated	mediate	VERB
fnp-3806	1971	29	innate	innate	ADJ
fnp-3806	1971	30	immunity	immunity	NOUN
fnp-3806	1971	31	in	in	ADP
fnp-3806	1971	32	alzheimer	alzheimer	PROPN
fnp-3806	1971	33	's	's	PART
fnp-3806	1971	34	disease	disease	NOUN
fnp-3806	1971	35	.	.	PUNCT
fnp-3806	1972	1	nat	nat	PROPN
fnp-3806	1972	2	genet	genet	PROPN
fnp-3806	1972	3	2017;49:1373	2017;49:1373	PROPN
fnp-3806	1972	4	-	-	SYM
fnp-3806	1972	5	1384	1384	NUM
fnp-3806	1972	6	.	.	PUNCT
fnp-3806	1973	1	https://doi.org/10.1038/ng.3916	https://doi.org/10.1038/ng.3916	PRON
fnp-3806	1973	2	marioni	marioni	NOUN
fnp-3806	1973	3	re	re	PROPN
fnp-3806	1973	4	,	,	PUNCT
fnp-3806	1973	5	harris	harris	PROPN
fnp-3806	1973	6	se	se	PROPN
fnp-3806	1973	7	,	,	PUNCT
fnp-3806	1973	8	zhang	zhang	PROPN
fnp-3806	1973	9	q	q	PROPN
fnp-3806	1973	10	,	,	PUNCT
fnp-3806	1973	11	et	et	PROPN
fnp-3806	1973	12	al	al	PROPN
fnp-3806	1973	13	.	.	PROPN
fnp-3806	1973	14	gwas	gwas	PROPN
fnp-3806	1973	15	on	on	ADP
fnp-3806	1973	16	family	family	NOUN
fnp-3806	1973	17	history	history	NOUN
fnp-3806	1973	18	of	of	ADP
fnp-3806	1973	19	alzheimer	alzheimer	PROPN
fnp-3806	1973	20	's	's	PART
fnp-3806	1973	21	disease	disease	NOUN
fnp-3806	1973	22	.	.	PUNCT
fnp-3806	1974	1	transl	transl	PROPN
fnp-3806	1974	2	psychiat	psychiat	PROPN
fnp-3806	1974	3	2018	2018	NUM
fnp-3806	1974	4	;	;	PUNCT
fnp-3806	1974	5	8	8	NUM
fnp-3806	1974	6	:	:	SYM
fnp-3806	1974	7	99	99	NUM
fnp-3806	1974	8	.	.	PUNCT
fnp-3806	1974	9	https://doi.org/10.1038/s41398-018-0150-6	https://doi.org/10.1038/s41398-018-0150-6	NOUN
fnp-3806	1974	10	pimenova	pimenova	VERB
fnp-3806	1974	11	aa	aa	PROPN
fnp-3806	1974	12	,	,	PUNCT
fnp-3806	1974	13	raj	raj	PROPN
fnp-3806	1974	14	t	t	PROPN
fnp-3806	1974	15	,	,	PUNCT
fnp-3806	1974	16	goate	goate	NOUN
fnp-3806	1974	17	am	am	NOUN
fnp-3806	1974	18	.	.	PUNCT
fnp-3806	1975	1	untangling	untangle	VERB
fnp-3806	1975	2	genetic	genetic	ADJ
fnp-3806	1975	3	risk	risk	NOUN
fnp-3806	1975	4	for	for	ADP
fnp-3806	1975	5	alzheimer	alzheimer	PROPN
fnp-3806	1975	6	's	's	PART
fnp-3806	1975	7	disease	disease	NOUN
fnp-3806	1975	8	.	.	PUNCT
fnp-3806	1976	1	biol	biol	PROPN
fnp-3806	1976	2	psychiat	psychiat	PROPN
fnp-3806	1976	3	2018	2018	NUM
fnp-3806	1976	4	;	;	PUNCT
fnp-3806	1976	5	83	83	NUM
fnp-3806	1976	6	:	:	SYM
fnp-3806	1976	7	300	300	NUM
fnp-3806	1976	8	-	-	SYM
fnp-3806	1976	9	310	310	NUM
fnp-3806	1976	10	.	.	PUNCT
fnp-3806	1977	1	https://doi.org/10.1016/j.biopsych.2017.05.014	https://doi.org/10.1016/j.biopsych.2017.05.014	PROPN
fnp-3806	1977	2	jansen	jansen	PROPN
fnp-3806	1977	3	ie	ie	X
fnp-3806	1977	4	,	,	PUNCT
fnp-3806	1977	5	savage	savage	NOUN
fnp-3806	1977	6	je	je	PROPN
fnp-3806	1977	7	,	,	PUNCT
fnp-3806	1977	8	watanabe	watanabe	PROPN
fnp-3806	1977	9	k	k	PROPN
fnp-3806	1977	10	,	,	PUNCT
fnp-3806	1977	11	et	et	PROPN
fnp-3806	1977	12	al	al	PROPN
fnp-3806	1977	13	.	.	PUNCT
fnp-3806	1977	14	genome	genome	NOUN
fnp-3806	1977	15	-	-	PUNCT
fnp-3806	1977	16	wide	wide	ADJ
fnp-3806	1977	17	meta	meta	ADJ
fnp-3806	1977	18	-	-	PUNCT
fnp-3806	1977	19	analysis	analysis	NOUN
fnp-3806	1977	20	identifies	identify	VERB
fnp-3806	1977	21	new	new	ADJ
fnp-3806	1977	22	loci	locus	NOUN
fnp-3806	1977	23	and	and	CCONJ
fnp-3806	1977	24	functional	functional	ADJ
fnp-3806	1977	25	pathways	pathway	NOUN
fnp-3806	1977	26	influencing	influence	VERB
fnp-3806	1977	27	alzheimer	alzheimer	PROPN
fnp-3806	1977	28	's	's	PART
fnp-3806	1977	29	disease	disease	NOUN
fnp-3806	1977	30	risk	risk	NOUN
fnp-3806	1977	31	.	.	PUNCT
fnp-3806	1978	1	nat	nat	PROPN
fnp-3806	1978	2	genet	genet	PROPN
fnp-3806	1978	3	2019	2019	NUM
fnp-3806	1978	4	;	;	PUNCT
fnp-3806	1978	5	51	51	NUM
fnp-3806	1978	6	:	:	SYM
fnp-3806	1978	7	404	404	NUM
fnp-3806	1978	8	-	-	SYM
fnp-3806	1978	9	413	413	NUM
fnp-3806	1978	10	.	.	PUNCT
fnp-3806	1979	1	https://doi.org/10.1038/s41588-018-0311-9	https://doi.org/10.1038/s41588-018-0311-9	X
fnp-3806	1979	2	kunkle	kunkle	PROPN
fnp-3806	1979	3	bw	bw	PROPN
fnp-3806	1979	4	,	,	PUNCT
fnp-3806	1979	5	grenier	grenier	NOUN
fnp-3806	1979	6	-	-	PUNCT
fnp-3806	1979	7	boley	boley	PROPN
fnp-3806	1979	8	b	b	NOUN
fnp-3806	1979	9	,	,	PUNCT
fnp-3806	1979	10	sims	sim	NOUN
fnp-3806	1979	11	r	r	NOUN
fnp-3806	1979	12	,	,	PUNCT
fnp-3806	1979	13	et	et	PROPN
fnp-3806	1979	14	al	al	PROPN
fnp-3806	1979	15	.	.	PUNCT
fnp-3806	1980	1	genetic	genetic	ADJ
fnp-3806	1980	2	meta	meta	ADJ
fnp-3806	1980	3	-	-	PUNCT
fnp-3806	1980	4	analysis	analysis	NOUN
fnp-3806	1980	5	of	of	ADP
fnp-3806	1980	6	diagnosed	diagnose	VERB
fnp-3806	1980	7	alzheimer	alzheimer	PROPN
fnp-3806	1980	8	’s	’s	PART
fnp-3806	1980	9	disease	disease	NOUN
fnp-3806	1980	10	identifies	identify	VERB
fnp-3806	1980	11	new	new	ADJ
fnp-3806	1980	12	risk	risk	NOUN
fnp-3806	1980	13	loci	loci	NOUN
fnp-3806	1980	14	and	and	CCONJ
fnp-3806	1980	15	implicates	implicate	VERB
fnp-3806	1980	16	aβ	aβ	PROPN
fnp-3806	1980	17	,	,	PUNCT
fnp-3806	1980	18	tau	tau	PROPN
fnp-3806	1980	19	,	,	PUNCT
fnp-3806	1980	20	immunity	immunity	NOUN
fnp-3806	1980	21	and	and	CCONJ
fnp-3806	1980	22	lipid	lipid	NOUN
fnp-3806	1980	23	processing	processing	NOUN
fnp-3806	1980	24	.	.	PUNCT
fnp-3806	1981	1	nat	nat	PROPN
fnp-3806	1981	2	genet	genet	PROPN
fnp-3806	1981	3	2019	2019	NUM
fnp-3806	1981	4	;	;	PUNCT
fnp-3806	1981	5	51	51	NUM
fnp-3806	1981	6	:	:	PUNCT
fnp-3806	1981	7	414	414	NUM
fnp-3806	1981	8	-	-	SYM
fnp-3806	1981	9	430	430	NUM
fnp-3806	1981	10	.	.	PUNCT
fnp-3806	1981	11	https://doi.org/10.1038/s41588-019-0358-2	https://doi.org/10.1038/s41588-019-0358-2	NOUN
fnp-3806	1981	12	andrews	andrews	PROPN
fnp-3806	1981	13	sj	sj	PROPN
fnp-3806	1981	14	,	,	PUNCT
fnp-3806	1981	15	fulton	fulton	PROPN
fnp-3806	1981	16	-	-	PUNCT
fnp-3806	1981	17	howard	howard	PROPN
fnp-3806	1981	18	b	b	PROPN
fnp-3806	1981	19	,	,	PUNCT
fnp-3806	1981	20	goate	goate	NOUN
fnp-3806	1981	21	a.	a.	NOUN
fnp-3806	1981	22	interpretation	interpretation	NOUN
fnp-3806	1981	23	of	of	ADP
fnp-3806	1981	24	risk	risk	NOUN
fnp-3806	1981	25	loci	loci	NOUN
fnp-3806	1981	26	from	from	ADP
fnp-3806	1981	27	genome	genome	NOUN
fnp-3806	1981	28	-	-	PUNCT
fnp-3806	1981	29	wide	wide	ADJ
fnp-3806	1981	30	association	association	NOUN
fnp-3806	1981	31	studies	study	NOUN
fnp-3806	1981	32	of	of	ADP
fnp-3806	1981	33	alzheimer	alzheimer	PROPN
fnp-3806	1981	34	's	's	PART
fnp-3806	1981	35	disease	disease	NOUN
fnp-3806	1981	36	.	.	PUNCT
fnp-3806	1982	1	lancet	lancet	PROPN
fnp-3806	1982	2	neurol	neurol	PROPN
fnp-3806	1982	3	2020;19:326	2020;19:326	NOUN
fnp-3806	1982	4	-	-	PUNCT
fnp-3806	1982	5	335	335	NUM
fnp-3806	1982	6	.	.	PUNCT
fnp-3806	1983	1	https://doi.org/10.1016/s1474-4422(19)30435-1	https://doi.org/10.1016/s1474-4422(19)30435-1	PROPN
fnp-3806	1983	2	tansey	tansey	NOUN
fnp-3806	1983	3	ke	ke	PROPN
fnp-3806	1983	4	,	,	PUNCT
fnp-3806	1983	5	cameron	cameron	PROPN
fnp-3806	1983	6	d	d	PROPN
fnp-3806	1983	7	,	,	PUNCT
fnp-3806	1983	8	hill	hill	PROPN
fnp-3806	1983	9	mj	mj	PROPN
fnp-3806	1983	10	.	.	PUNCT
fnp-3806	1984	1	genetic	genetic	ADJ
fnp-3806	1984	2	risk	risk	NOUN
fnp-3806	1984	3	for	for	ADP
fnp-3806	1984	4	alzheimer	alzheimer	PROPN
fnp-3806	1984	5	's	's	PART
fnp-3806	1984	6	disease	disease	NOUN
fnp-3806	1984	7	is	be	AUX
fnp-3806	1984	8	concentrated	concentrate	VERB
fnp-3806	1984	9	in	in	ADP
fnp-3806	1984	10	specific	specific	ADJ
fnp-3806	1984	11	macrophage	macrophage	ADJ
fnp-3806	1984	12	and	and	CCONJ
fnp-3806	1984	13	microglial	microglial	ADJ
fnp-3806	1984	14	transcriptional	transcriptional	NOUN
fnp-3806	1984	15	networks	network	NOUN
fnp-3806	1984	16	.	.	PUNCT
fnp-3806	1985	1	genome	genome	NOUN
fnp-3806	1985	2	med	me	VERB
fnp-3806	1985	3	2018;10:14	2018;10:14	NUM
fnp-3806	1985	4	.	.	PUNCT
fnp-3806	1986	1	https://doi.org/10.1186/s13073-018-0523-8	https://doi.org/10.1186/s13073-018-0523-8	NUM
fnp-3806	1986	2	bellenguez	bellenguez	PROPN
fnp-3806	1986	3	c	c	NOUN
fnp-3806	1986	4	,	,	PUNCT
fnp-3806	1986	5	grenier	grenier	NOUN
fnp-3806	1986	6	-	-	PUNCT
fnp-3806	1986	7	boley	boley	PROPN
fnp-3806	1986	8	b	b	PROPN
fnp-3806	1986	9	,	,	PUNCT
fnp-3806	1986	10	lambert	lambert	PROPN
fnp-3806	1986	11	jc	jc	PROPN
fnp-3806	1986	12	.	.	PROPN
fnp-3806	1987	1	genetics	genetics	PROPN
fnp-3806	1987	2	of	of	ADP
fnp-3806	1987	3	alzheimer	alzheimer	PROPN
fnp-3806	1987	4	's	's	PART
fnp-3806	1987	5	disease	disease	NOUN
fnp-3806	1987	6	:	:	PUNCT
fnp-3806	1987	7	where	where	SCONJ
fnp-3806	1987	8	we	we	PRON
fnp-3806	1987	9	are	be	AUX
fnp-3806	1987	10	,	,	PUNCT
fnp-3806	1987	11	and	and	CCONJ
fnp-3806	1987	12	where	where	SCONJ
fnp-3806	1987	13	we	we	PRON
fnp-3806	1987	14	are	be	AUX
fnp-3806	1987	15	going	go	VERB
fnp-3806	1987	16	.	.	PUNCT
fnp-3806	1988	1	curr	curr	PROPN
fnp-3806	1988	2	opin	opin	PROPN
fnp-3806	1988	3	neurobiol	neurobiol	PROPN
fnp-3806	1988	4	2020;61:40	2020;61:40	NUM
fnp-3806	1988	5	-	-	SYM
fnp-3806	1988	6	48	48	NUM
fnp-3806	1988	7	.	.	PUNCT
fnp-3806	1989	1	https://doi.org/10.1016/j.conb.2019.11.024	https://doi.org/10.1016/j.conb.2019.11.024	VERB
fnp-3806	1989	2	bellenguez	bellenguez	PROPN
fnp-3806	1989	3	c	c	NOUN
fnp-3806	1989	4	,	,	PUNCT
fnp-3806	1989	5	küçükali	küçükali	PROPN
fnp-3806	1989	6	f	f	PROPN
fnp-3806	1989	7	,	,	PUNCT
fnp-3806	1989	8	jansen	jansen	PROPN
fnp-3806	1989	9	ie	ie	X
fnp-3806	1989	10	,	,	PUNCT
fnp-3806	1989	11	et	et	PROPN
fnp-3806	1989	12	al	al	PROPN
fnp-3806	1989	13	.	.	PUNCT
fnp-3806	1990	1	new	new	ADJ
fnp-3806	1990	2	insights	insight	NOUN
fnp-3806	1990	3	into	into	ADP
fnp-3806	1990	4	the	the	DET
fnp-3806	1990	5	genetic	genetic	ADJ
fnp-3806	1990	6	etiology	etiology	NOUN
fnp-3806	1990	7	of	of	ADP
fnp-3806	1990	8	alzheimer	alzheimer	PROPN
fnp-3806	1990	9	’s	’s	PART
fnp-3806	1990	10	disease	disease	NOUN
fnp-3806	1990	11	and	and	CCONJ
fnp-3806	1990	12	related	related	ADJ
fnp-3806	1990	13	dementias	dementia	NOUN
fnp-3806	1990	14	.	.	PUNCT
fnp-3806	1991	1	nat	nat	PROPN
fnp-3806	1991	2	genet	genet	PROPN
fnp-3806	1991	3	2022;54:412	2022;54:412	PROPN
fnp-3806	1991	4	-	-	SYM
fnp-3806	1991	5	436	436	NUM
fnp-3806	1991	6	.	.	PUNCT
fnp-3806	1992	1	https://doi.org/10.1038/s41588-022-01024-z	https://doi.org/10.1038/s41588-022-01024-z	PROPN
fnp-3806	1992	2	vogt	vogt	PROPN
fnp-3806	1992	3	ba	ba	PROPN
fnp-3806	1992	4	,	,	PUNCT
fnp-3806	1992	5	vogt	vogt	PROPN
fnp-3806	1992	6	lj	lj	PROPN
fnp-3806	1992	7	,	,	PUNCT
fnp-3806	1992	8	hof	hof	PROPN
fnp-3806	1992	9	pr	pr	NOUN
fnp-3806	1992	10	.	.	PUNCT
fnp-3806	1993	1	patterns	pattern	NOUN
fnp-3806	1993	2	of	of	ADP
fnp-3806	1993	3	cortical	cortical	ADJ
fnp-3806	1993	4	neurodegeneration	neurodegeneration	NOUN
fnp-3806	1993	5	in	in	ADP
fnp-3806	1993	6	alzheimer	alzheimer	PROPN
fnp-3806	1993	7	’s	’s	PART
fnp-3806	1993	8	disease	disease	NOUN
fnp-3806	1993	9	:	:	PUNCT
fnp-3806	1993	10	subgroups	subgroup	NOUN
fnp-3806	1993	11	,	,	PUNCT
fnp-3806	1993	12	subtypes	subtype	NOUN
fnp-3806	1993	13	,	,	PUNCT
fnp-3806	1993	14	and	and	CCONJ
fnp-3806	1993	15	implications	implication	NOUN
fnp-3806	1993	16	for	for	ADP
fnp-3806	1993	17	staging	stage	VERB
fnp-3806	1993	18	strategies	strategy	NOUN
fnp-3806	1993	19	.	.	PUNCT
fnp-3806	1994	1	in	in	ADP
fnp-3806	1994	2	functional	functional	ADJ
fnp-3806	1994	3	neurobiology	neurobiology	NOUN
fnp-3806	1994	4	of	of	ADP
fnp-3806	1994	5	aging	aging	NOUN
fnp-3806	1994	6	.	.	PUNCT
fnp-3806	1995	1	hof	hof	PROPN
fnp-3806	1995	2	pr	pr	PROPN
fnp-3806	1995	3	,	,	PUNCT
fnp-3806	1995	4	mobbs	mobbs	PROPN
fnp-3806	1995	5	cv	cv	PROPN
fnp-3806	1995	6	(	(	PUNCT
fnp-3806	1995	7	eds	ed	NOUN
fnp-3806	1995	8	)	)	PUNCT
fnp-3806	1995	9	.	.	PUNCT
fnp-3806	1996	1	academic	academic	ADJ
fnp-3806	1996	2	press	press	NOUN
fnp-3806	1996	3	2001	2001	NUM
fnp-3806	1996	4	,	,	PUNCT
fnp-3806	1996	5	pp	pp	CCONJ
fnp-3806	1996	6	:	:	PUNCT
fnp-3806	1996	7	111	111	NUM
fnp-3806	1996	8	-	-	SYM
fnp-3806	1996	9	129	129	NUM
fnp-3806	1996	10	hof	hof	NOUN
fnp-3806	1996	11	pr	pr	NOUN
fnp-3806	1996	12	,	,	PUNCT
fnp-3806	1996	13	cox	cox	PROPN
fnp-3806	1996	14	k	k	PROPN
fnp-3806	1996	15	,	,	PUNCT
fnp-3806	1996	16	morrison	morrison	PROPN
fnp-3806	1996	17	jh	jh	PROPN
fnp-3806	1996	18	.	.	PUNCT
fnp-3806	1997	1	quantitative	quantitative	ADJ
fnp-3806	1997	2	analysis	analysis	NOUN
fnp-3806	1997	3	of	of	ADP
fnp-3806	1997	4	a	a	DET
fnp-3806	1997	5	vulnerable	vulnerable	ADJ
fnp-3806	1997	6	subset	subset	NOUN
fnp-3806	1997	7	of	of	ADP
fnp-3806	1997	8	pyramidal	pyramidal	ADJ
fnp-3806	1997	9	neurons	neuron	NOUN
fnp-3806	1997	10	in	in	ADP
fnp-3806	1997	11	alzheimer	alzheimer	PROPN
fnp-3806	1997	12	's	's	PART
fnp-3806	1997	13	disease	disease	NOUN
fnp-3806	1997	14	:	:	PUNCT
fnp-3806	1997	15	i.	i.	PROPN
fnp-3806	1997	16	superior	superior	PROPN
fnp-3806	1997	17	frontal	frontal	ADJ
fnp-3806	1997	18	and	and	CCONJ
fnp-3806	1997	19	inferior	inferior	ADJ
fnp-3806	1997	20	temporal	temporal	ADJ
fnp-3806	1997	21	cortex	cortex	NOUN
fnp-3806	1997	22	.	.	PUNCT
fnp-3806	1998	1	j	j	PROPN
fnp-3806	1998	2	comp	comp	PROPN
fnp-3806	1998	3	neurol	neurol	VERB
fnp-3806	1998	4	1990;301:44	1990;301:44	NUM
fnp-3806	1998	5	-	-	SYM
fnp-3806	1998	6	54	54	NUM
fnp-3806	1998	7	.	.	PUNCT
fnp-3806	1999	1	https://doi.org/10.1002/cne.903010105	https://doi.org/10.1002/cne.903010105	ADJ
fnp-3806	1999	2	hof	hof	PROPN
fnp-3806	1999	3	pr	pr	PROPN
fnp-3806	1999	4	,	,	PUNCT
fnp-3806	1999	5	morrison	morrison	PROPN
fnp-3806	1999	6	jh	jh	PROPN
fnp-3806	1999	7	.	.	PUNCT
fnp-3806	2000	1	quantitative	quantitative	ADJ
fnp-3806	2000	2	analysis	analysis	NOUN
fnp-3806	2000	3	of	of	ADP
fnp-3806	2000	4	a	a	DET
fnp-3806	2000	5	vulnerable	vulnerable	ADJ
fnp-3806	2000	6	subset	subset	NOUN
fnp-3806	2000	7	of	of	ADP
fnp-3806	2000	8	pyramidal	pyramidal	ADJ
fnp-3806	2000	9	neurons	neuron	NOUN
fnp-3806	2000	10	in	in	ADP
fnp-3806	2000	11	alzheimer	alzheimer	PROPN
fnp-3806	2000	12	's	's	PART
fnp-3806	2000	13	disease	disease	NOUN
fnp-3806	2000	14	:	:	PUNCT
fnp-3806	2000	15	ii	ii	PROPN
fnp-3806	2000	16	.	.	PUNCT
fnp-3806	2000	17	primary	primary	ADJ
fnp-3806	2000	18	and	and	CCONJ
fnp-3806	2000	19	secondary	secondary	ADJ
fnp-3806	2000	20	visual	visual	ADJ
fnp-3806	2000	21	cortex	cortex	NOUN
fnp-3806	2000	22	.	.	PUNCT
fnp-3806	2001	1	j	j	PROPN
fnp-3806	2001	2	comp	comp	PROPN
fnp-3806	2001	3	neurol	neurol	PROPN
fnp-3806	2001	4	1990;30:55	1990;30:55	NUM
fnp-3806	2001	5	-	-	SYM
fnp-3806	2001	6	64	64	NUM
fnp-3806	2001	7	.	.	PUNCT
fnp-3806	2002	1	https://doi.org/10.1002/cne.903010106	https://doi.org/10.1002/cne.903010106	PROPN
fnp-3806	2002	2	morrison	morrison	PROPN
fnp-3806	2002	3	jh	jh	PROPN
fnp-3806	2002	4	,	,	PUNCT
fnp-3806	2002	5	lewis	lewis	PROPN
fnp-3806	2002	6	da	da	PROPN
fnp-3806	2002	7	,	,	PUNCT
fnp-3806	2002	8	campbell	campbell	PROPN
fnp-3806	2002	9	mj	mj	PROPN
fnp-3806	2002	10	,	,	PUNCT
fnp-3806	2002	11	et	et	PROPN
fnp-3806	2002	12	al	al	PROPN
fnp-3806	2002	13	.	.	PUNCT
fnp-3806	2003	1	a	a	DET
fnp-3806	2003	2	monoclonal	monoclonal	NOUN
fnp-3806	2003	3	antibody	antibody	NOUN
fnp-3806	2003	4	to	to	ADP
fnp-3806	2003	5	non	non	ADJ
fnp-3806	2003	6	-	-	ADJ
fnp-3806	2003	7	phosphorylated	phosphorylate	VERB
fnp-3806	2003	8	neurofilament	neurofilament	NOUN
fnp-3806	2003	9	protein	protein	NOUN
fnp-3806	2003	10	marks	mark	VERB
fnp-3806	2003	11	the	the	DET
fnp-3806	2003	12	vulnerable	vulnerable	ADJ
fnp-3806	2003	13	cortical	cortical	ADJ
fnp-3806	2003	14	neurons	neuron	NOUN
fnp-3806	2003	15	in	in	ADP
fnp-3806	2003	16	alzheimer	alzheimer	PROPN
fnp-3806	2003	17	's	's	PART
fnp-3806	2003	18	disease	disease	NOUN
fnp-3806	2003	19	.	.	PUNCT
fnp-3806	2004	1	brain	brain	NOUN
fnp-3806	2004	2	res	re	NOUN
fnp-3806	2004	3	1987;416:331	1987;416:331	NUM
fnp-3806	2004	4	-	-	SYM
fnp-3806	2004	5	336	336	NUM
fnp-3806	2004	6	.	.	PUNCT
fnp-3806	2005	1	https://doi.org/10.1016/0006-8993(87)90914-0	https://doi.org/10.1016/0006-8993(87)90914-0	NOUN
fnp-3806	2005	2	vickers	vickers	PROPN
fnp-3806	2005	3	jc	jc	PROPN
fnp-3806	2005	4	,	,	PUNCT
fnp-3806	2005	5	riederer	riederer	PROPN
fnp-3806	2005	6	bm	bm	PROPN
fnp-3806	2005	7	,	,	PUNCT
fnp-3806	2005	8	marugg	marugg	PROPN
fnp-3806	2005	9	ra	ra	PROPN
fnp-3806	2005	10	,	,	PUNCT
fnp-3806	2005	11	et	et	PROPN
fnp-3806	2005	12	al	al	PROPN
fnp-3806	2005	13	.	.	PUNCT
fnp-3806	2005	14	alterations	alteration	NOUN
fnp-3806	2005	15	in	in	ADP
fnp-3806	2005	16	neurofilament	neurofilament	ADJ
fnp-3806	2005	17	protein	protein	NOUN
fnp-3806	2005	18	immunoreactivity	immunoreactivity	NOUN
fnp-3806	2005	19	in	in	ADP
fnp-3806	2005	20	human	human	ADJ
fnp-3806	2005	21	hippocampal	hippocampal	ADJ
fnp-3806	2005	22	neurons	neuron	NOUN
fnp-3806	2005	23	related	relate	VERB
fnp-3806	2005	24	to	to	ADP
fnp-3806	2005	25	normal	normal	ADJ
fnp-3806	2005	26	aging	aging	NOUN
fnp-3806	2005	27	and	and	CCONJ
fnp-3806	2005	28	alzheimer	alzheimer	NOUN
fnp-3806	2005	29	's	's	PART
fnp-3806	2005	30	disease	disease	NOUN
fnp-3806	2005	31	.	.	PUNCT
fnp-3806	2006	1	neuroscience	neuroscience	NOUN
fnp-3806	2006	2	1994;62:1	1994;62:1	NUM
fnp-3806	2006	3	-	-	SYM
fnp-3806	2006	4	13	13	NUM
fnp-3806	2006	5	.	.	PUNCT
fnp-3806	2007	1	https://doi.org/10.1016/0306-4522(94)90310-7	https://doi.org/10.1016/0306-4522(94)90310-7	PROPN
fnp-3806	2007	2	morrison	morrison	PROPN
fnp-3806	2007	3	jh	jh	PROPN
fnp-3806	2007	4	,	,	PUNCT
fnp-3806	2007	5	hof	hof	PROPN
fnp-3806	2007	6	pr	pr	NOUN
fnp-3806	2007	7	.	.	PUNCT
fnp-3806	2008	1	life	life	NOUN
fnp-3806	2008	2	and	and	CCONJ
fnp-3806	2008	3	death	death	NOUN
fnp-3806	2008	4	of	of	ADP
fnp-3806	2008	5	neurons	neuron	NOUN
fnp-3806	2008	6	in	in	ADP
fnp-3806	2008	7	the	the	DET
fnp-3806	2008	8	aging	age	VERB
fnp-3806	2008	9	brain	brain	NOUN
fnp-3806	2008	10	.	.	PUNCT
fnp-3806	2009	1	science	science	NOUN
fnp-3806	2009	2	1997;278:412	1997;278:412	NUM
fnp-3806	2009	3	-	-	SYM
fnp-3806	2009	4	419	419	NUM
fnp-3806	2009	5	.	.	PUNCT
fnp-3806	2010	1	https://doi.org/10.1126/science.278.5337	https://doi.org/10.1126/science.278.5337	NOUN
fnp-3806	2010	2	412	412	NUM
fnp-3806	2010	3	.	.	PUNCT
fnp-3806	2011	1	vickers	vickers	PROPN
fnp-3806	2011	2	jc	jc	PROPN
fnp-3806	2011	3	,	,	PUNCT
fnp-3806	2011	4	dickson	dickson	PROPN
fnp-3806	2011	5	tc	tc	PROPN
fnp-3806	2011	6	,	,	PUNCT
fnp-3806	2011	7	adlard	adlard	PROPN
fnp-3806	2011	8	pa	pa	PROPN
fnp-3806	2011	9	,	,	PUNCT
fnp-3806	2011	10	et	et	PROPN
fnp-3806	2011	11	al	al	PROPN
fnp-3806	2011	12	.	.	PUNCT
fnp-3806	2012	1	the	the	DET
fnp-3806	2012	2	cause	cause	NOUN
fnp-3806	2012	3	of	of	ADP
fnp-3806	2012	4	neuronal	neuronal	ADJ
fnp-3806	2012	5	degeneration	degeneration	NOUN
fnp-3806	2012	6	in	in	ADP
fnp-3806	2012	7	alzheimer	alzheimer	PROPN
fnp-3806	2012	8	's	's	PART
fnp-3806	2012	9	disease	disease	NOUN
fnp-3806	2012	10	.	.	PUNCT
fnp-3806	2013	1	prog	prog	PROPN
fnp-3806	2013	2	neurobiol	neurobiol	PROPN
fnp-3806	2013	3	2000;60:139	2000;60:139	NUM
fnp-3806	2013	4	-	-	SYM
fnp-3806	2013	5	165	165	NUM
fnp-3806	2013	6	.	.	PUNCT
fnp-3806	2014	1	https://doi.org/10.1016/s0301-0082(99)00023-4	https://doi.org/10.1016/s0301-0082(99)00023-4	PROPN
fnp-3806	2014	2	chan	chan	PROPN
fnp-3806	2014	3	-	-	PUNCT
fnp-3806	2014	4	palay	palay	NOUN
fnp-3806	2014	5	v.	v.	ADP
fnp-3806	2014	6	somatostatin	somatostatin	NOUN
fnp-3806	2014	7	immunoreactive	immunoreactive	ADJ
fnp-3806	2014	8	neurons	neuron	NOUN
fnp-3806	2014	9	in	in	ADP
fnp-3806	2014	10	the	the	DET
fnp-3806	2014	11	human	human	ADJ
fnp-3806	2014	12	hippocampus	hippocampus	NOUN
fnp-3806	2014	13	and	and	CCONJ
fnp-3806	2014	14	cortex	cortex	NOUN
fnp-3806	2014	15	shown	show	VERB
fnp-3806	2014	16	by	by	ADP
fnp-3806	2014	17	immunogold	immunogold	ADJ
fnp-3806	2014	18	/	/	SYM
fnp-3806	2014	19	silver	silver	NOUN
fnp-3806	2014	20	intensification	intensification	NOUN
fnp-3806	2014	21	on	on	ADP
fnp-3806	2014	22	vibratome	vibratome	ADJ
fnp-3806	2014	23	sections	section	NOUN
fnp-3806	2014	24	:	:	PUNCT
fnp-3806	2014	25	coexistence	coexistence	NOUN
fnp-3806	2014	26	with	with	ADP
fnp-3806	2014	27	neuropeptide	neuropeptide	NOUN
fnp-3806	2014	28	y	y	PROPN
fnp-3806	2014	29	neurons	neuron	NOUN
fnp-3806	2014	30	,	,	PUNCT
fnp-3806	2014	31	and	and	CCONJ
fnp-3806	2014	32	effects	effect	NOUN
fnp-3806	2014	33	in	in	ADP
fnp-3806	2014	34	alzheimer	alzheimer	ADJ
fnp-3806	2014	35	-	-	PUNCT
fnp-3806	2014	36	type	type	NOUN
fnp-3806	2014	37	dementia	dementia	NOUN
fnp-3806	2014	38	.	.	PUNCT
fnp-3806	2015	1	j	j	PROPN
fnp-3806	2015	2	comp	comp	PROPN
fnp-3806	2015	3	neurol	neurol	PROPN
fnp-3806	2015	4	1987	1987	NUM
fnp-3806	2015	5	;	;	PUNCT
fnp-3806	2015	6	260	260	NUM
fnp-3806	2015	7	:	:	PUNCT
fnp-3806	2015	8	201	201	NUM
fnp-3806	2015	9	-	-	SYM
fnp-3806	2015	10	223	223	NUM
fnp-3806	2015	11	.	.	PUNCT
fnp-3806	2016	1	https://doi.org/10.1002/cne.902600205	https://doi.org/10.1002/cne.902600205	PROPN
fnp-3806	2016	2	rossor	rossor	PROPN
fnp-3806	2016	3	mn	mn	PROPN
fnp-3806	2016	4	,	,	PUNCT
fnp-3806	2016	5	emson	emson	PROPN
fnp-3806	2016	6	pc	pc	PROPN
fnp-3806	2016	7	,	,	PUNCT
fnp-3806	2016	8	mountjoy	mountjoy	PROPN
fnp-3806	2016	9	cq	cq	PROPN
fnp-3806	2016	10	,	,	PUNCT
fnp-3806	2016	11	et	et	PROPN
fnp-3806	2016	12	al	al	PROPN
fnp-3806	2016	13	.	.	PROPN
fnp-3806	2016	14	reduced	reduce	VERB
fnp-3806	2016	15	amounts	amount	NOUN
fnp-3806	2016	16	of	of	ADP
fnp-3806	2016	17	immunoreactive	immunoreactive	ADJ
fnp-3806	2016	18	somatostatin	somatostatin	NOUN
fnp-3806	2016	19	in	in	ADP
fnp-3806	2016	20	the	the	DET
fnp-3806	2016	21	temporal	temporal	ADJ
fnp-3806	2016	22	cortex	cortex	NOUN
fnp-3806	2016	23	in	in	ADP
fnp-3806	2016	24	senile	senile	ADJ
fnp-3806	2016	25	dementia	dementia	NOUN
fnp-3806	2016	26	of	of	ADP
fnp-3806	2016	27	alzheimer	alzheimer	PROPN
fnp-3806	2016	28	type	type	NOUN
fnp-3806	2016	29	.	.	PUNCT
fnp-3806	2017	1	neurosci	neurosci	PROPN
fnp-3806	2017	2	lett	lett	PROPN
fnp-3806	2017	3	1980	1980	NUM
fnp-3806	2017	4	;	;	PUNCT
fnp-3806	2017	5	20	20	NUM
fnp-3806	2017	6	:	:	SYM
fnp-3806	2017	7	373	373	NUM
fnp-3806	2017	8	-	-	SYM
fnp-3806	2017	9	377	377	NUM
fnp-3806	2017	10	.	.	PUNCT
fnp-3806	2018	1	https://doi.org/10.1016/0304-3940(80)90177-9	https://doi.org/10.1016/0304-3940(80)90177-9	PROPN
fnp-3806	2018	2	rossor	rossor	PROPN
fnp-3806	2018	3	mn	mn	PROPN
fnp-3806	2018	4	,	,	PUNCT
fnp-3806	2018	5	garrett	garrett	PROPN
fnp-3806	2018	6	nj	nj	PROPN
fnp-3806	2018	7	,	,	PUNCT
fnp-3806	2018	8	johnson	johnson	PROPN
fnp-3806	2018	9	al	al	PROPN
fnp-3806	2018	10	,	,	PUNCT
fnp-3806	2018	11	et	et	PROPN
fnp-3806	2018	12	al	al	PROPN
fnp-3806	2018	13	.	.	PUNCT
fnp-3806	2019	1	a	a	DET
fnp-3806	2019	2	post	post	ADJ
fnp-3806	2019	3	-	-	ADJ
fnp-3806	2019	4	mortem	mortem	ADJ
fnp-3806	2019	5	study	study	NOUN
fnp-3806	2019	6	of	of	ADP
fnp-3806	2019	7	the	the	DET
fnp-3806	2019	8	cholinergic	cholinergic	ADJ
fnp-3806	2019	9	and	and	CCONJ
fnp-3806	2019	10	gaba	gaba	NOUN
fnp-3806	2019	11	systems	system	NOUN
fnp-3806	2019	12	in	in	ADP
fnp-3806	2019	13	senile	senile	ADJ
fnp-3806	2019	14	dementia	dementia	NOUN
fnp-3806	2019	15	.	.	PUNCT
fnp-3806	2020	1	brain	brain	NOUN
fnp-3806	2020	2	1982;105:313	1982;105:313	NUM
fnp-3806	2020	3	-	-	SYM
fnp-3806	2020	4	330	330	NUM
fnp-3806	2020	5	.	.	PUNCT
fnp-3806	2021	1	https://doi.org/10.1093/brain/105.2.313	https://doi.org/10.1093/brain/105.2.313	VERB
fnp-3806	2021	2	hardy	hardy	PROPN
fnp-3806	2021	3	j	j	PROPN
fnp-3806	2021	4	,	,	PUNCT
fnp-3806	2021	5	cowburn	cowburn	VERB
fnp-3806	2021	6	r	r	NOUN
fnp-3806	2021	7	,	,	PUNCT
fnp-3806	2021	8	barton	barton	PROPN
fnp-3806	2021	9	a	a	PROPN
fnp-3806	2021	10	,	,	PUNCT
fnp-3806	2021	11	et	et	PROPN
fnp-3806	2021	12	al	al	PROPN
fnp-3806	2021	13	.	.	PUNCT
fnp-3806	2022	1	a	a	DET
fnp-3806	2022	2	disorder	disorder	NOUN
fnp-3806	2022	3	of	of	ADP
fnp-3806	2022	4	cortical	cortical	ADJ
fnp-3806	2022	5	gabaergic	gabaergic	ADJ
fnp-3806	2022	6	innervation	innervation	NOUN
fnp-3806	2022	7	in	in	ADP
fnp-3806	2022	8	alzheimer	alzheimer	PROPN
fnp-3806	2022	9	's	's	PART
fnp-3806	2022	10	disease	disease	NOUN
fnp-3806	2022	11	.	.	PUNCT
fnp-3806	2023	1	neurosci	neurosci	PROPN
fnp-3806	2023	2	lett	lett	PROPN
fnp-3806	2023	3	1987;73:192	1987;73:192	PROPN
fnp-3806	2023	4	-	-	SYM
fnp-3806	2023	5	196	196	NUM
fnp-3806	2023	6	.	.	PUNCT
fnp-3806	2024	1	https://doi.org/10.1016/0304-3940(87)90016-4	https://doi.org/10.1016/0304-3940(87)90016-4	PROPN
fnp-3806	2024	2	simpson	simpson	PROPN
fnp-3806	2024	3	md	md	PROPN
fnp-3806	2024	4	,	,	PUNCT
fnp-3806	2024	5	cross	cross	PROPN
fnp-3806	2024	6	aj	aj	PROPN
fnp-3806	2024	7	,	,	PUNCT
fnp-3806	2024	8	slater	slater	PROPN
fnp-3806	2024	9	p	p	PROPN
fnp-3806	2024	10	,	,	PUNCT
fnp-3806	2024	11	deakin	deakin	PROPN
fnp-3806	2024	12	jf	jf	PROPN
fnp-3806	2024	13	.	.	PUNCT
fnp-3806	2024	14	loss	loss	PROPN
fnp-3806	2024	15	of	of	ADP
fnp-3806	2024	16	cortical	cortical	ADJ
fnp-3806	2024	17	gaba	gaba	NOUN
fnp-3806	2024	18	uptake	uptake	ADJ
fnp-3806	2024	19	sites	site	NOUN
fnp-3806	2024	20	in	in	ADP
fnp-3806	2024	21	alzheimer	alzheimer	PROPN
fnp-3806	2024	22	's	's	PART
fnp-3806	2024	23	disease	disease	NOUN
fnp-3806	2024	24	.	.	PUNCT
fnp-3806	2025	1	j	j	PROPN
fnp-3806	2025	2	neural	neural	PROPN
fnp-3806	2025	3	transm	transm	PROPN
fnp-3806	2025	4	1988;71:219	1988;71:219	PROPN
fnp-3806	2025	5	-	-	SYM
fnp-3806	2025	6	226	226	NUM
fnp-3806	2025	7	.	.	PUNCT
fnp-3806	2026	1	https://doi.org/10.1007/bf01245715	https://doi.org/10.1007/bf01245715	PROPN
fnp-3806	2026	2	gabriel	gabriel	PROPN
fnp-3806	2026	3	sm	sm	PROPN
fnp-3806	2026	4	,	,	PUNCT
fnp-3806	2026	5	bierer	bierer	PROPN
fnp-3806	2026	6	lm	lm	PROPN
fnp-3806	2026	7	,	,	PUNCT
fnp-3806	2026	8	harotunian	harotunian	NOUN
fnp-3806	2026	9	v	v	NOUN
fnp-3806	2026	10	,	,	PUNCT
fnp-3806	2026	11	et	et	PROPN
fnp-3806	2026	12	al	al	PROPN
fnp-3806	2026	13	.	.	PROPN
fnp-3806	2027	1	widespread	widespread	ADJ
fnp-3806	2027	2	deficits	deficit	NOUN
fnp-3806	2027	3	in	in	ADP
fnp-3806	2027	4	somatostatin	somatostatin	NOUN
fnp-3806	2027	5	but	but	CCONJ
fnp-3806	2027	6	not	not	PART
fnp-3806	2027	7	neuropeptide	neuropeptide	VERB
fnp-3806	2027	8	y	y	PROPN
fnp-3806	2027	9	concentrations	concentration	NOUN
fnp-3806	2027	10	in	in	ADP
fnp-3806	2027	11	alzheimer	alzheimer	PROPN
fnp-3806	2027	12	's	's	PART
fnp-3806	2027	13	disease	disease	NOUN
fnp-3806	2027	14	cerebral	cerebral	ADJ
fnp-3806	2027	15	cortex	cortex	NOUN
fnp-3806	2027	16	.	.	PUNCT
fnp-3806	2028	1	neurosci	neurosci	PROPN
fnp-3806	2028	2	lett	lett	PROPN
fnp-3806	2028	3	1993;155:116	1993;155:116	PROPN
fnp-3806	2028	4	-	-	SYM
fnp-3806	2028	5	120	120	NUM
fnp-3806	2028	6	.	.	PUNCT
fnp-3806	2029	1	https://doi.org/10.1016/0304-3940(93)90686-f	https://doi.org/10.1016/0304-3940(93)90686-f	NOUN
fnp-3806	2029	2	beal	beal	PROPN
fnp-3806	2029	3	mf	mf	PROPN
fnp-3806	2029	4	,	,	PUNCT
fnp-3806	2029	5	mazurek	mazurek	NOUN
fnp-3806	2029	6	mf	mf	PROPN
fnp-3806	2029	7	,	,	PUNCT
fnp-3806	2029	8	tran	tran	PROPN
fnp-3806	2029	9	vt	vt	PROPN
fnp-3806	2029	10	,	,	PUNCT
fnp-3806	2029	11	et	et	PROPN
fnp-3806	2029	12	al	al	PROPN
fnp-3806	2029	13	.	.	PROPN
fnp-3806	2030	1	reduced	reduce	VERB
fnp-3806	2030	2	numbers	number	NOUN
fnp-3806	2030	3	of	of	ADP
fnp-3806	2030	4	somatostatin	somatostatin	NOUN
fnp-3806	2030	5	receptors	receptor	NOUN
fnp-3806	2030	6	in	in	ADP
fnp-3806	2030	7	the	the	DET
fnp-3806	2030	8	cerebral	cerebral	ADJ
fnp-3806	2030	9	cortex	cortex	NOUN
fnp-3806	2030	10	in	in	ADP
fnp-3806	2030	11	alzheimer	alzheimer	PROPN
fnp-3806	2030	12	's	's	PART
fnp-3806	2030	13	disease	disease	NOUN
fnp-3806	2030	14	.	.	PUNCT
fnp-3806	2031	1	science	science	NOUN
fnp-3806	2031	2	1985;229:289	1985;229:289	NUM
fnp-3806	2031	3	-	-	SYM
fnp-3806	2031	4	291	291	NUM
fnp-3806	2031	5	.	.	PUNCT
fnp-3806	2031	6	https://doi.org/10.1126/science.2861661	https://doi.org/10.1126/science.2861661	VERB
fnp-3806	2031	7	baimbridge	baimbridge	PROPN
fnp-3806	2031	8	kg	kg	PROPN
fnp-3806	2031	9	,	,	PUNCT
fnp-3806	2031	10	celio	celio	PROPN
fnp-3806	2031	11	mr	mr	PROPN
fnp-3806	2031	12	,	,	PUNCT
fnp-3806	2031	13	rogers	rogers	PROPN
fnp-3806	2031	14	jh	jh	PROPN
fnp-3806	2031	15	.	.	PUNCT
fnp-3806	2031	16	calcium	calcium	NOUN
fnp-3806	2031	17	-	-	PUNCT
fnp-3806	2031	18	binding	bind	VERB
fnp-3806	2031	19	proteins	protein	NOUN
fnp-3806	2031	20	in	in	ADP
fnp-3806	2031	21	the	the	DET
fnp-3806	2031	22	nervous	nervous	ADJ
fnp-3806	2031	23	system	system	NOUN
fnp-3806	2031	24	.	.	PUNCT
fnp-3806	2032	1	trends	trend	NOUN
fnp-3806	2032	2	neurosci	neurosci	VERB
fnp-3806	2032	3	1992;15:303	1992;15:303	NOUN
fnp-3806	2032	4	-	-	SYM
fnp-3806	2032	5	308	308	NUM
fnp-3806	2032	6	.	.	PUNCT
fnp-3806	2033	1	https://doi.org/10.1016/0166-2236(92)90081-i	https://doi.org/10.1016/0166-2236(92)90081-i	ADJ
fnp-3806	2033	2	klausberger	klausberger	NOUN
fnp-3806	2033	3	t	t	PROPN
fnp-3806	2033	4	,	,	PUNCT
fnp-3806	2033	5	somogyi	somogyi	ADJ
fnp-3806	2033	6	p.	p.	NOUN
fnp-3806	2033	7	neuronal	neuronal	ADJ
fnp-3806	2033	8	diversity	diversity	NOUN
fnp-3806	2033	9	and	and	CCONJ
fnp-3806	2033	10	temporal	temporal	ADJ
fnp-3806	2033	11	dynamics	dynamic	NOUN
fnp-3806	2033	12	:	:	PUNCT
fnp-3806	2033	13	the	the	DET
fnp-3806	2033	14	unity	unity	NOUN
fnp-3806	2033	15	of	of	ADP
fnp-3806	2033	16	hippocampal	hippocampal	ADJ
fnp-3806	2033	17	circuit	circuit	NOUN
fnp-3806	2033	18	operations	operation	NOUN
fnp-3806	2033	19	.	.	PUNCT
fnp-3806	2034	1	science	science	NOUN
fnp-3806	2034	2	2008;321:53	2008;321:53	NOUN
fnp-3806	2034	3	-	-	SYM
fnp-3806	2034	4	57	57	NUM
fnp-3806	2034	5	.	.	PUNCT
fnp-3806	2035	1	https://doi.org/10.1126/science.1149381	https://doi.org/10.1126/science.1149381	PROPN
fnp-3806	2035	2	tremblay	tremblay	PROPN
fnp-3806	2035	3	r	r	PROPN
fnp-3806	2035	4	,	,	PUNCT
fnp-3806	2035	5	lee	lee	PROPN
fnp-3806	2035	6	s	s	PROPN
fnp-3806	2035	7	,	,	PUNCT
fnp-3806	2035	8	rudy	rudy	PROPN
fnp-3806	2035	9	b.	b.	PROPN
fnp-3806	2036	1	gabaergic	gabaergic	ADJ
fnp-3806	2036	2	interneurons	interneuron	NOUN
fnp-3806	2036	3	in	in	ADP
fnp-3806	2036	4	the	the	DET
fnp-3806	2036	5	neocortex	neocortex	NOUN
fnp-3806	2036	6	:	:	PUNCT
fnp-3806	2036	7	from	from	ADP
fnp-3806	2036	8	cellular	cellular	ADJ
fnp-3806	2036	9	properties	property	NOUN
fnp-3806	2036	10	to	to	ADP
fnp-3806	2036	11	circuits	circuit	NOUN
fnp-3806	2036	12	.	.	PUNCT
fnp-3806	2037	1	neuron	neuron	PROPN
fnp-3806	2037	2	2016;91:260	2016;91:260	PROPN
fnp-3806	2037	3	-	-	SYM
fnp-3806	2037	4	292	292	NUM
fnp-3806	2037	5	.	.	PUNCT
fnp-3806	2038	1	https://doi.org/10.1016/j.neuron.2016.06.033	https://doi.org/10.1016/j.neuron.2016.06.033	PROPN
fnp-3806	2038	2	ferrer	ferrer	PROPN
fnp-3806	2038	3	i	i	PROPN
fnp-3806	2038	4	,	,	PUNCT
fnp-3806	2038	5	soriano	soriano	PROPN
fnp-3806	2038	6	e	e	PROPN
fnp-3806	2038	7	,	,	PUNCT
fnp-3806	2038	8	tuñón	tuñón	PROPN
fnp-3806	2038	9	t	t	PROPN
fnp-3806	2038	10	,	,	PUNCT
fnp-3806	2038	11	et	et	PROPN
fnp-3806	2038	12	al	al	PROPN
fnp-3806	2038	13	.	.	PROPN
fnp-3806	2038	14	parvalbumin	parvalbumin	PROPN
fnp-3806	2038	15	immunoreactive	immunoreactive	ADJ
fnp-3806	2038	16	neurons	neuron	NOUN
fnp-3806	2038	17	in	in	ADP
fnp-3806	2038	18	normal	normal	ADJ
fnp-3806	2038	19	human	human	ADJ
fnp-3806	2038	20	temporal	temporal	ADJ
fnp-3806	2038	21	neocortex	neocortex	NOUN
fnp-3806	2038	22	and	and	CCONJ
fnp-3806	2038	23	in	in	ADP
fnp-3806	2038	24	patients	patient	NOUN
fnp-3806	2038	25	with	with	ADP
fnp-3806	2038	26	alzheimer	alzheimer	PROPN
fnp-3806	2038	27	's	's	PART
fnp-3806	2038	28	disease	disease	NOUN
fnp-3806	2038	29	.	.	PUNCT
fnp-3806	2039	1	j	j	PROPN
fnp-3806	2039	2	neurol	neurol	PROPN
fnp-3806	2039	3	sci	sci	PROPN
fnp-3806	2039	4	1991;106:135	1991;106:135	PROPN
fnp-3806	2039	5	-	-	SYM
fnp-3806	2039	6	141	141	NUM
fnp-3806	2039	7	.	.	PUNCT
fnp-3806	2040	1	https://doi.org/10.1016/0022-510x(91)90250-b	https://doi.org/10.1016/0022-510x(91)90250-b	PROPN
fnp-3806	2040	2	hof	hof	NOUN
fnp-3806	2040	3	pr	pr	NOUN
fnp-3806	2040	4	,	,	PUNCT
fnp-3806	2040	5	cox	cox	PROPN
fnp-3806	2040	6	k	k	PROPN
fnp-3806	2040	7	,	,	PUNCT
fnp-3806	2040	8	young	young	PROPN
fnp-3806	2040	9	wg	wg	PROPN
fnp-3806	2040	10	,	,	PUNCT
fnp-3806	2040	11	et	et	PROPN
fnp-3806	2040	12	al	al	PROPN
fnp-3806	2040	13	.	.	PUNCT
fnp-3806	2040	14	parvalbumin	parvalbumin	PROPN
fnp-3806	2040	15	-	-	PUNCT
fnp-3806	2040	16	immunoreactive	immunoreactive	ADJ
fnp-3806	2040	17	neurons	neuron	NOUN
fnp-3806	2040	18	in	in	ADP
fnp-3806	2040	19	the	the	DET
fnp-3806	2040	20	neocortex	neocortex	NOUN
fnp-3806	2040	21	are	be	AUX
fnp-3806	2040	22	resistant	resistant	ADJ
fnp-3806	2040	23	to	to	ADP
fnp-3806	2040	24	degeneration	degeneration	NOUN
fnp-3806	2040	25	in	in	ADP
fnp-3806	2040	26	alzheimer	alzheimer	PROPN
fnp-3806	2040	27	's	's	PART
fnp-3806	2040	28	disease	disease	NOUN
fnp-3806	2040	29	.	.	PUNCT
fnp-3806	2041	1	j	j	PROPN
fnp-3806	2041	2	neuropathol	neuropathol	PROPN
fnp-3806	2041	3	exp	exp	PROPN
fnp-3806	2041	4	neurol	neurol	PROPN
fnp-3806	2041	5	1991;50:451	1991;50:451	PROPN
fnp-3806	2041	6	-	-	PUNCT
fnp-3806	2041	7	462	462	NUM
fnp-3806	2041	8	.	.	PUNCT
fnp-3806	2041	9	https://doi.org/10.1097/00005072-199107000-00006	https://doi.org/10.1097/00005072-199107000-00006	PROPN
fnp-3806	2041	10	sampson	sampson	PROPN
fnp-3806	2041	11	vl	vl	PROPN
fnp-3806	2041	12	,	,	PUNCT
fnp-3806	2041	13	morrison	morrison	PROPN
fnp-3806	2041	14	jh	jh	PROPN
fnp-3806	2041	15	,	,	PUNCT
fnp-3806	2041	16	vickers	vickers	PROPN
fnp-3806	2041	17	jc	jc	PROPN
fnp-3806	2041	18	.	.	PUNCT
fnp-3806	2042	1	the	the	DET
fnp-3806	2042	2	cellular	cellular	ADJ
fnp-3806	2042	3	basis	basis	NOUN
fnp-3806	2042	4	for	for	ADP
fnp-3806	2042	5	the	the	DET
fnp-3806	2042	6	relative	relative	ADJ
fnp-3806	2042	7	resistance	resistance	NOUN
fnp-3806	2042	8	of	of	ADP
fnp-3806	2042	9	parvalbumin	parvalbumin	NOUN
fnp-3806	2042	10	and	and	CCONJ
fnp-3806	2042	11	calretinin	calretinin	VERB
fnp-3806	2042	12	immunoreactive	immunoreactive	ADJ
fnp-3806	2042	13	neocortical	neocortical	ADJ
fnp-3806	2042	14	neurons	neuron	NOUN
fnp-3806	2042	15	to	to	ADP
fnp-3806	2042	16	the	the	DET
fnp-3806	2042	17	pathology	pathology	NOUN
fnp-3806	2042	18	of	of	ADP
fnp-3806	2042	19	alzheimer	alzheimer	PROPN
fnp-3806	2042	20	's	's	PART
fnp-3806	2042	21	disease	disease	NOUN
fnp-3806	2042	22	.	.	PUNCT
fnp-3806	2043	1	exp	exp	NOUN
fnp-3806	2043	2	neurol	neurol	PROPN
fnp-3806	2043	3	1997;145:295	1997;145:295	NUM
fnp-3806	2043	4	-	-	SYM
fnp-3806	2043	5	302	302	NUM
fnp-3806	2043	6	.	.	PUNCT
fnp-3806	2044	1	https://doi.org/10.1006/exnr.1997.6433	https://doi.org/10.1006/exnr.1997.6433	PROPN
fnp-3806	2044	2	leuba	leuba	PROPN
fnp-3806	2044	3	g	g	PROPN
fnp-3806	2044	4	,	,	PUNCT
fnp-3806	2044	5	kraftsik	kraftsik	PROPN
fnp-3806	2044	6	r	r	PROPN
fnp-3806	2044	7	,	,	PUNCT
fnp-3806	2044	8	saini	saini	PROPN
fnp-3806	2044	9	k.	k.	PROPN
fnp-3806	2044	10	quantitative	quantitative	ADJ
fnp-3806	2044	11	distribution	distribution	NOUN
fnp-3806	2044	12	of	of	ADP
fnp-3806	2044	13	parvalbumin	parvalbumin	NOUN
fnp-3806	2044	14	,	,	PUNCT
fnp-3806	2044	15	calretinin	calretinin	NOUN
fnp-3806	2044	16	,	,	PUNCT
fnp-3806	2044	17	and	and	CCONJ
fnp-3806	2044	18	calbindin	calbindin	VERB
fnp-3806	2044	19	d-28k	d-28k	ADJ
fnp-3806	2044	20	immunoreactive	immunoreactive	ADJ
fnp-3806	2044	21	neurons	neuron	NOUN
fnp-3806	2044	22	in	in	ADP
fnp-3806	2044	23	the	the	DET
fnp-3806	2044	24	visual	visual	ADJ
fnp-3806	2044	25	cortex	cortex	NOUN
fnp-3806	2044	26	of	of	ADP
fnp-3806	2044	27	normal	normal	ADJ
fnp-3806	2044	28	and	and	CCONJ
fnp-3806	2044	29	alzheimer	alzheimer	NOUN
fnp-3806	2044	30	cases	case	NOUN
fnp-3806	2044	31	.	.	PUNCT
fnp-3806	2045	1	exp	exp	NOUN
fnp-3806	2045	2	neurol	neurol	NOUN
fnp-3806	2045	3	1998;152:278	1998;152:278	NUM
fnp-3806	2045	4	-	-	SYM
fnp-3806	2045	5	291	291	NUM
fnp-3806	2045	6	.	.	PUNCT
fnp-3806	2046	1	https://doi.org/10.1006/exnr.1998.6838	https://doi.org/10.1006/exnr.1998.6838	PROPN
fnp-3806	2046	2	arai	arai	PROPN
fnp-3806	2046	3	h	h	NOUN
fnp-3806	2046	4	,	,	PUNCT
fnp-3806	2046	5	emson	emson	PROPN
fnp-3806	2046	6	pc	pc	PROPN
fnp-3806	2046	7	,	,	PUNCT
fnp-3806	2046	8	mountjoy	mountjoy	PROPN
fnp-3806	2046	9	cq	cq	PROPN
fnp-3806	2046	10	,	,	PUNCT
fnp-3806	2046	11	et	et	PROPN
fnp-3806	2046	12	al	al	PROPN
fnp-3806	2046	13	.	.	PUNCT
fnp-3806	2046	14	loss	loss	NOUN
fnp-3806	2046	15	of	of	ADP
fnp-3806	2046	16	parvalbumin	parvalbumin	ADJ
fnp-3806	2046	17	-	-	PUNCT
fnp-3806	2046	18	immunoreactive	immunoreactive	ADJ
fnp-3806	2046	19	neurones	neurone	NOUN
fnp-3806	2046	20	from	from	ADP
fnp-3806	2046	21	cortex	cortex	NOUN
fnp-3806	2046	22	in	in	ADP
fnp-3806	2046	23	alzheimer	alzheimer	ADJ
fnp-3806	2046	24	-	-	PUNCT
fnp-3806	2046	25	type	type	NOUN
fnp-3806	2046	26	dementia	dementia	NOUN
fnp-3806	2046	27	.	.	PUNCT
fnp-3806	2047	1	brain	brain	NOUN
fnp-3806	2047	2	res	re	NOUN
fnp-3806	2047	3	1987;418:164	1987;418:164	NUM
fnp-3806	2047	4	-	-	SYM
fnp-3806	2047	5	169	169	NUM
fnp-3806	2047	6	.	.	PUNCT
fnp-3806	2048	1	https://doi.org/10.1016/0006-8993(87)90974-7	https://doi.org/10.1016/0006-8993(87)90974-7	PROPN
fnp-3806	2048	2	brady	brady	PROPN
fnp-3806	2048	3	dr	dr	PROPN
fnp-3806	2048	4	,	,	PUNCT
fnp-3806	2048	5	mufson	mufson	PROPN
fnp-3806	2048	6	ej	ej	PROPN
fnp-3806	2048	7	.	.	PUNCT
fnp-3806	2048	8	parvalbumin	parvalbumin	VERB
fnp-3806	2048	9	-	-	PUNCT
fnp-3806	2048	10	immunoreactive	immunoreactive	ADJ
fnp-3806	2048	11	neurons	neuron	NOUN
fnp-3806	2048	12	in	in	ADP
fnp-3806	2048	13	the	the	DET
fnp-3806	2048	14	hippocampal	hippocampal	ADJ
fnp-3806	2048	15	formation	formation	NOUN
fnp-3806	2048	16	of	of	ADP
fnp-3806	2048	17	alzheimer	alzheimer	PROPN
fnp-3806	2048	18	's	's	PART
fnp-3806	2048	19	diseased	diseased	ADJ
fnp-3806	2048	20	brain	brain	NOUN
fnp-3806	2048	21	.	.	PUNCT
fnp-3806	2049	1	neuroscience	neuroscience	NOUN
fnp-3806	2049	2	1997;80:1113	1997;80:1113	NUM
fnp-3806	2049	3	-	-	SYM
fnp-3806	2049	4	1125	1125	NUM
fnp-3806	2049	5	.	.	PUNCT
fnp-3806	2050	1	https://doi.org/10.1016/s0306-4522(97)00068-7	https://doi.org/10.1016/s0306-4522(97)00068-7	PROPN
fnp-3806	2050	2	fonseca	fonseca	PROPN
fnp-3806	2050	3	m	m	PROPN
fnp-3806	2050	4	,	,	PUNCT
fnp-3806	2050	5	soriano	soriano	PROPN
fnp-3806	2050	6	e	e	PROPN
fnp-3806	2050	7	,	,	PUNCT
fnp-3806	2050	8	ferrer	ferrer	PROPN
fnp-3806	2050	9	i	i	PROPN
fnp-3806	2050	10	,	,	PUNCT
fnp-3806	2050	11	et	et	PROPN
fnp-3806	2050	12	al	al	PROPN
fnp-3806	2050	13	.	.	PUNCT
fnp-3806	2051	1	chandelier	chandelier	PROPN
fnp-3806	2051	2	cell	cell	NOUN
fnp-3806	2051	3	axons	axon	NOUN
fnp-3806	2051	4	identified	identify	VERB
fnp-3806	2051	5	by	by	ADP
fnp-3806	2051	6	parvalbumin	parvalbumin	NOUN
fnp-3806	2051	7	-	-	PUNCT
fnp-3806	2051	8	immunoreactivity	immunoreactivity	NOUN
fnp-3806	2051	9	in	in	ADP
fnp-3806	2051	10	the	the	DET
fnp-3806	2051	11	normal	normal	ADJ
fnp-3806	2051	12	human	human	ADJ
fnp-3806	2051	13	temporal	temporal	ADJ
fnp-3806	2051	14	cortex	cortex	NOUN
fnp-3806	2051	15	and	and	CCONJ
fnp-3806	2051	16	in	in	ADP
fnp-3806	2051	17	alzheimer	alzheimer	PROPN
fnp-3806	2051	18	's	's	PART
fnp-3806	2051	19	disease	disease	NOUN
fnp-3806	2051	20	.	.	PUNCT
fnp-3806	2052	1	neuroscience	neuroscience	NOUN
fnp-3806	2052	2	1993	1993	NUM
fnp-3806	2052	3	;	;	PUNCT
fnp-3806	2052	4	55	55	NUM
fnp-3806	2052	5	:	:	SYM
fnp-3806	2052	6	1107	1107	NUM
fnp-3806	2052	7	-	-	SYM
fnp-3806	2052	8	1116	1116	NUM
fnp-3806	2052	9	.	.	PUNCT
fnp-3806	2053	1	https://doi.org/10.1016/0306-4522(93)90324-9	https://doi.org/10.1016/0306-4522(93)90324-9	ADJ
fnp-3806	2053	2	inaguma	inaguma	PROPN
fnp-3806	2053	3	y	y	NOUN
fnp-3806	2053	4	,	,	PUNCT
fnp-3806	2053	5	shinohara	shinohara	PROPN
fnp-3806	2053	6	h	h	PROPN
fnp-3806	2053	7	,	,	PUNCT
fnp-3806	2053	8	inagaki	inagaki	PROPN
fnp-3806	2053	9	t	t	PROPN
fnp-3806	2053	10	,	,	PUNCT
fnp-3806	2053	11	et	et	PROPN
fnp-3806	2053	12	al	al	PROPN
fnp-3806	2053	13	.	.	PROPN
fnp-3806	2054	1	immunoreactive	immunoreactive	PROPN
fnp-3806	2054	2	parvalbumin	parvalbumin	ADJ
fnp-3806	2054	3	concentrations	concentration	NOUN
fnp-3806	2054	4	in	in	ADP
fnp-3806	2054	5	parahippocampal	parahippocampal	ADJ
fnp-3806	2054	6	gyrus	gyrus	NOUN
fnp-3806	2054	7	decrease	decrease	NOUN
fnp-3806	2054	8	in	in	ADP
fnp-3806	2054	9	patients	patient	NOUN
fnp-3806	2054	10	with	with	ADP
fnp-3806	2054	11	alzheimer	alzheimer	PROPN
fnp-3806	2054	12	's	's	PART
fnp-3806	2054	13	disease	disease	NOUN
fnp-3806	2054	14	.	.	PUNCT
fnp-3806	2055	1	j	j	PROPN
fnp-3806	2055	2	neurol	neurol	PROPN
fnp-3806	2055	3	sci	sci	PROPN
fnp-3806	2055	4	1992;110:57	1992;110:57	NUM
fnp-3806	2055	5	-	-	SYM
fnp-3806	2055	6	61	61	NUM
fnp-3806	2055	7	.	.	PUNCT
fnp-3806	2056	1	https://doi.org/10.1016/0022-510x(92)90009-a	https://doi.org/10.1016/0022-510x(92)90009-a	NOUN
fnp-3806	2056	2	mikkonen	mikkonen	PROPN
fnp-3806	2056	3	m	m	PROPN
fnp-3806	2056	4	,	,	PUNCT
fnp-3806	2056	5	alafuzoff	alafuzoff	NOUN
fnp-3806	2056	6	i	i	PRON
fnp-3806	2056	7	,	,	PUNCT
fnp-3806	2056	8	tapiola	tapiola	PROPN
fnp-3806	2056	9	t	t	PROPN
fnp-3806	2056	10	,	,	PUNCT
fnp-3806	2056	11	et	et	PROPN
fnp-3806	2056	12	al	al	PROPN
fnp-3806	2056	13	.	.	PROPN
fnp-3806	2056	14	subfieldand	subfieldand	PROPN
fnp-3806	2056	15	layer	layer	NOUN
fnp-3806	2056	16	-	-	PUNCT
fnp-3806	2056	17	specific	specific	ADJ
fnp-3806	2056	18	changes	change	NOUN
fnp-3806	2056	19	in	in	ADP
fnp-3806	2056	20	parvalbumin	parvalbumin	ADJ
fnp-3806	2056	21	,	,	PUNCT
fnp-3806	2056	22	calretinin	calretinin	NOUN
fnp-3806	2056	23	and	and	CCONJ
fnp-3806	2056	24	calbindin	calbindin	VERB
fnp-3806	2056	25	-	-	PUNCT
fnp-3806	2056	26	d28k	d28k	PROPN
fnp-3806	2056	27	immunoreactivity	immunoreactivity	NOUN
fnp-3806	2056	28	in	in	ADP
fnp-3806	2056	29	the	the	DET
fnp-3806	2056	30	entorhinal	entorhinal	ADJ
fnp-3806	2056	31	cortex	cortex	NOUN
fnp-3806	2056	32	in	in	ADP
fnp-3806	2056	33	alzheimer	alzheimer	PROPN
fnp-3806	2056	34	's	's	PART
fnp-3806	2056	35	disease	disease	NOUN
fnp-3806	2056	36	.	.	PUNCT
fnp-3806	2057	1	neuroscience	neuroscience	NOUN
fnp-3806	2057	2	1999;92:515	1999;92:515	NOUN
fnp-3806	2057	3	-	-	SYM
fnp-3806	2057	4	532	532	NUM
fnp-3806	2057	5	.	.	PUNCT
fnp-3806	2058	1	https://doi.org/10.1016/s0306-4522(99)00047-0	https://doi.org/10.1016/s0306-4522(99)00047-0	PROPN
fnp-3806	2058	2	satoh	satoh	PROPN
fnp-3806	2058	3	j	j	PROPN
fnp-3806	2058	4	,	,	PUNCT
fnp-3806	2058	5	tabira	tabira	PROPN
fnp-3806	2058	6	t	t	PROPN
fnp-3806	2058	7	,	,	PUNCT
fnp-3806	2058	8	sano	sano	PROPN
fnp-3806	2058	9	m	m	PROPN
fnp-3806	2058	10	,	,	PUNCT
fnp-3806	2058	11	et	et	PROPN
fnp-3806	2058	12	al	al	PROPN
fnp-3806	2058	13	.	.	PUNCT
fnp-3806	2058	14	parvalbumin	parvalbumin	PROPN
fnp-3806	2058	15	-	-	PUNCT
fnp-3806	2058	16	immunoreactive	immunoreactive	ADJ
fnp-3806	2058	17	neurons	neuron	NOUN
fnp-3806	2058	18	in	in	ADP
fnp-3806	2058	19	the	the	DET
fnp-3806	2058	20	human	human	ADJ
fnp-3806	2058	21	central	central	ADJ
fnp-3806	2058	22	nervous	nervous	ADJ
fnp-3806	2058	23	system	system	NOUN
fnp-3806	2058	24	are	be	AUX
fnp-3806	2058	25	decreased	decrease	VERB
fnp-3806	2058	26	in	in	ADP
fnp-3806	2058	27	alzheimer	alzheimer	PROPN
fnp-3806	2058	28	's	's	PART
fnp-3806	2058	29	disease	disease	NOUN
fnp-3806	2058	30	.	.	PUNCT
fnp-3806	2059	1	acta	acta	PROPN
fnp-3806	2059	2	neuropathol	neuropathol	PROPN
fnp-3806	2059	3	1991	1991	NUM
fnp-3806	2059	4	;	;	PUNCT
fnp-3806	2059	5	81:388	81:388	NUM
fnp-3806	2059	6	-	-	SYM
fnp-3806	2059	7	395	395	NUM
fnp-3806	2059	8	.	.	PUNCT
fnp-3806	2060	1	https://doi.org/10.1007/bf00293459	https://doi.org/10.1007/bf00293459	X
fnp-3806	2061	1	solodkin	solodkin	PROPN
fnp-3806	2061	2	a	a	DET
fnp-3806	2061	3	,	,	PUNCT
fnp-3806	2061	4	veldhuizen	veldhuizen	NOUN
fnp-3806	2061	5	sd	sd	NOUN
fnp-3806	2061	6	,	,	PUNCT
fnp-3806	2061	7	van	van	PROPN
fnp-3806	2061	8	hoesen	hoesen	NOUN
fnp-3806	2061	9	gw	gw	PROPN
fnp-3806	2062	1	.	.	PUNCT
fnp-3806	2062	2	contingent	contingent	ADJ
fnp-3806	2062	3	vulnerability	vulnerability	NOUN
fnp-3806	2062	4	of	of	ADP
fnp-3806	2062	5	entorhinal	entorhinal	ADJ
fnp-3806	2062	6	parvalbumin	parvalbumin	NOUN
fnp-3806	2062	7	-	-	PUNCT
fnp-3806	2062	8	containing	contain	VERB
fnp-3806	2062	9	neurons	neuron	NOUN
fnp-3806	2062	10	in	in	ADP
fnp-3806	2062	11	alzheimer	alzheimer	PROPN
fnp-3806	2062	12	's	's	PART
fnp-3806	2062	13	disease	disease	NOUN
fnp-3806	2062	14	.	.	PUNCT
fnp-3806	2063	1	j	j	PROPN
fnp-3806	2063	2	neurosci	neurosci	PROPN
fnp-3806	2063	3	1996;16:3311	1996;16:3311	NUM
fnp-3806	2063	4	-	-	PUNCT
fnp-3806	2063	5	3321	3321	NUM
fnp-3806	2063	6	.	.	PUNCT
fnp-3806	2064	1	hof	hof	PROPN
fnp-3806	2064	2	pr	pr	PROPN
fnp-3806	2064	3	,	,	PUNCT
fnp-3806	2064	4	morrison	morrison	PROPN
fnp-3806	2064	5	jh	jh	PROPN
fnp-3806	2064	6	.	.	PUNCT
fnp-3806	2065	1	neocortical	neocortical	ADJ
fnp-3806	2065	2	neuronal	neuronal	ADJ
fnp-3806	2065	3	subpopulations	subpopulation	NOUN
fnp-3806	2065	4	labeled	label	VERB
fnp-3806	2065	5	by	by	ADP
fnp-3806	2065	6	a	a	DET
fnp-3806	2065	7	monoclonal	monoclonal	NOUN
fnp-3806	2065	8	antibody	antibody	NOUN
fnp-3806	2065	9	to	to	ADP
fnp-3806	2065	10	calbindin	calbindin	VERB
fnp-3806	2065	11	exhibit	exhibit	NOUN
fnp-3806	2065	12	differential	differential	ADJ
fnp-3806	2065	13	vulnerability	vulnerability	NOUN
fnp-3806	2065	14	in	in	ADP
fnp-3806	2065	15	alzheimer	alzheimer	PROPN
fnp-3806	2065	16	's	's	PART
fnp-3806	2065	17	disease	disease	NOUN
fnp-3806	2065	18	.	.	PUNCT
fnp-3806	2066	1	exp	exp	NOUN
fnp-3806	2066	2	neurol	neurol	PROPN
fnp-3806	2066	3	1991;111:293	1991;111:293	NUM
fnp-3806	2066	4	-	-	SYM
fnp-3806	2066	5	301	301	NUM
fnp-3806	2066	6	.	.	PUNCT
fnp-3806	2067	1	https://doi.org/10.1523/jneurosci.16-10-03311.1996	https://doi.org/10.1523/jneurosci.16-10-03311.1996	X
fnp-3806	2067	2	ferrer	ferrer	PROPN
fnp-3806	2067	3	i	i	PRON
fnp-3806	2067	4	,	,	PUNCT
fnp-3806	2067	5	tuñon	tuñon	PROPN
fnp-3806	2067	6	t	t	PROPN
fnp-3806	2067	7	,	,	PUNCT
fnp-3806	2067	8	soriano	soriano	PROPN
fnp-3806	2067	9	e	e	PROPN
fnp-3806	2067	10	,	,	PUNCT
fnp-3806	2067	11	et	et	PROPN
fnp-3806	2067	12	al	al	PROPN
fnp-3806	2067	13	.	.	PUNCT
fnp-3806	2067	14	calbindin	calbindin	VERB
fnp-3806	2067	15	d-28k	d-28k	NUM
fnp-3806	2067	16	immunoreactivity	immunoreactivity	NOUN
fnp-3806	2067	17	in	in	ADP
fnp-3806	2067	18	the	the	DET
fnp-3806	2067	19	temporal	temporal	ADJ
fnp-3806	2067	20	neocortex	neocortex	NOUN
fnp-3806	2067	21	in	in	ADP
fnp-3806	2067	22	patients	patient	NOUN
fnp-3806	2067	23	with	with	ADP
fnp-3806	2067	24	alzheimer	alzheimer	PROPN
fnp-3806	2067	25	's	's	PART
fnp-3806	2067	26	disease	disease	NOUN
fnp-3806	2067	27	.	.	PUNCT
fnp-3806	2068	1	clin	clin	PROPN
fnp-3806	2068	2	neuropathol	neuropathol	PROPN
fnp-3806	2068	3	1993;12:53	1993;12:53	NUM
fnp-3806	2068	4	-	-	SYM
fnp-3806	2068	5	58	58	NUM
fnp-3806	2068	6	.	.	PUNCT
fnp-3806	2069	1	pmid	pmid	NOUN
fnp-3806	2069	2	:	:	PUNCT
fnp-3806	2069	3	8440080	8440080	NUM
fnp-3806	2069	4	fonseca	fonseca	PROPN
fnp-3806	2069	5	m	m	PROPN
fnp-3806	2069	6	,	,	PUNCT
fnp-3806	2069	7	soriano	soriano	PROPN
fnp-3806	2069	8	e.	e.	PROPN
fnp-3806	2069	9	calretinin	calretinin	PROPN
fnp-3806	2069	10	-	-	PUNCT
fnp-3806	2069	11	immunoreactive	immunoreactive	ADJ
fnp-3806	2069	12	neurons	neuron	NOUN
fnp-3806	2069	13	in	in	ADP
fnp-3806	2069	14	the	the	DET
fnp-3806	2069	15	normal	normal	ADJ
fnp-3806	2069	16	human	human	ADJ
fnp-3806	2069	17	temporal	temporal	ADJ
fnp-3806	2069	18	cortex	cortex	NOUN
fnp-3806	2069	19	and	and	CCONJ
fnp-3806	2069	20	in	in	ADP
fnp-3806	2069	21	alzheimer	alzheimer	PROPN
fnp-3806	2069	22	's	's	PART
fnp-3806	2069	23	disease	disease	NOUN
fnp-3806	2069	24	.	.	PUNCT
fnp-3806	2070	1	brain	brain	NOUN
fnp-3806	2070	2	res	re	NOUN
fnp-3806	2070	3	1995;691:83	1995;691:83	NUM
fnp-3806	2070	4	-	-	SYM
fnp-3806	2070	5	91	91	NUM
fnp-3806	2070	6	.	.	PUNCT
fnp-3806	2071	1	https://doi.org/10.1016/0006-8993(95)00622-w	https://doi.org/10.1016/0006-8993(95)00622-w	ADV
fnp-3806	2071	2	hof	hof	PROPN
fnp-3806	2071	3	pr	pr	NOUN
fnp-3806	2071	4	,	,	PUNCT
fnp-3806	2071	5	nimchinsky	nimchinsky	ADJ
fnp-3806	2071	6	ea	ea	PROPN
fnp-3806	2071	7	,	,	PUNCT
fnp-3806	2071	8	celio	celio	PROPN
fnp-3806	2071	9	mr	mr	PROPN
fnp-3806	2071	10	,	,	PUNCT
fnp-3806	2071	11	et	et	PROPN
fnp-3806	2071	12	al	al	PROPN
fnp-3806	2071	13	.	.	PUNCT
fnp-3806	2071	14	calretinin	calretinin	PROPN
fnp-3806	2071	15	-	-	PUNCT
fnp-3806	2071	16	immunoreactive	immunoreactive	ADJ
fnp-3806	2071	17	neocortical	neocortical	ADJ
fnp-3806	2071	18	interneurons	interneuron	NOUN
fnp-3806	2071	19	are	be	AUX
fnp-3806	2071	20	unaffected	unaffected	ADJ
fnp-3806	2071	21	in	in	ADP
fnp-3806	2071	22	alzheimer	alzheimer	PROPN
fnp-3806	2071	23	's	's	PART
fnp-3806	2071	24	disease	disease	NOUN
fnp-3806	2071	25	.	.	PUNCT
fnp-3806	2072	1	neurosci	neurosci	PROPN
fnp-3806	2072	2	lett	lett	PROPN
fnp-3806	2072	3	1993;152:145	1993;152:145	NUM
fnp-3806	2072	4	-	-	SYM
fnp-3806	2072	5	148	148	NUM
fnp-3806	2072	6	.	.	PUNCT
fnp-3806	2073	1	https://doi.org/10.1016/0304-3940(93)90504-e	https://doi.org/10.1016/0304-3940(93)90504-e	PROPN
fnp-3806	2073	2	brion	brion	PROPN
fnp-3806	2073	3	jp	jp	PROPN
fnp-3806	2073	4	,	,	PUNCT
fnp-3806	2073	5	resibois	resibois	PROPN
fnp-3806	2073	6	a.	a.	NOUN
fnp-3806	2073	7	a	a	DET
fnp-3806	2073	8	subset	subset	NOUN
fnp-3806	2073	9	of	of	ADP
fnp-3806	2073	10	calretinin	calretinin	ADJ
fnp-3806	2073	11	-	-	PUNCT
fnp-3806	2073	12	positive	positive	ADJ
fnp-3806	2073	13	neurons	neuron	NOUN
fnp-3806	2073	14	are	be	AUX
fnp-3806	2073	15	abnormal	abnormal	ADJ
fnp-3806	2073	16	in	in	ADP
fnp-3806	2073	17	alzheimer	alzheimer	PROPN
fnp-3806	2073	18	's	's	PART
fnp-3806	2073	19	disease	disease	NOUN
fnp-3806	2073	20	.	.	PUNCT
fnp-3806	2074	1	acta	acta	PROPN
fnp-3806	2074	2	neuropathol	neuropathol	PROPN
fnp-3806	2074	3	1994;88:33	1994;88:33	NUM
fnp-3806	2074	4	-	-	SYM
fnp-3806	2074	5	43	43	NUM
fnp-3806	2074	6	.	.	PUNCT
fnp-3806	2075	1	https://doi.org/10.1007/bf00294357	https://doi.org/10.1007/bf00294357	PROPN
fnp-3806	2075	2	west	west	PROPN
fnp-3806	2075	3	mj	mj	PROPN
fnp-3806	2075	4	,	,	PUNCT
fnp-3806	2075	5	coleman	coleman	PROPN
fnp-3806	2075	6	pd	pd	PROPN
fnp-3806	2075	7	,	,	PUNCT
fnp-3806	2075	8	flood	flood	NOUN
fnp-3806	2075	9	dg	dg	PROPN
fnp-3806	2075	10	,	,	PUNCT
fnp-3806	2075	11	et	et	PROPN
fnp-3806	2075	12	al	al	PROPN
fnp-3806	2075	13	.	.	PROPN
fnp-3806	2075	14	differences	difference	NOUN
fnp-3806	2075	15	in	in	ADP
fnp-3806	2075	16	the	the	DET
fnp-3806	2075	17	pattern	pattern	NOUN
fnp-3806	2075	18	of	of	ADP
fnp-3806	2075	19	hippocampal	hippocampal	ADJ
fnp-3806	2075	20	neuronal	neuronal	ADJ
fnp-3806	2075	21	loss	loss	NOUN
fnp-3806	2075	22	in	in	ADP
fnp-3806	2075	23	normal	normal	ADJ
fnp-3806	2075	24	ageing	ageing	NOUN
fnp-3806	2075	25	and	and	CCONJ
fnp-3806	2075	26	alzheimer	alzheimer	NOUN
fnp-3806	2075	27	's	's	PART
fnp-3806	2075	28	disease	disease	NOUN
fnp-3806	2075	29	.	.	PUNCT
fnp-3806	2076	1	lancet	lancet	PROPN
fnp-3806	2076	2	1994;344:769	1994;344:769	NUM
fnp-3806	2076	3	-	-	SYM
fnp-3806	2076	4	772	772	NUM
fnp-3806	2076	5	.	.	PUNCT
fnp-3806	2077	1	https://doi.org/10.1016/s0140-6736(94)92338-8	https://doi.org/10.1016/s0140-6736(94)92338-8	PROPN
fnp-3806	2077	2	gómez	gómez	PROPN
fnp-3806	2077	3	-	-	PUNCT
fnp-3806	2077	4	isla	isla	PROPN
fnp-3806	2077	5	t	t	PROPN
fnp-3806	2077	6	,	,	PUNCT
fnp-3806	2077	7	price	price	NOUN
fnp-3806	2077	8	jl	jl	NOUN
fnp-3806	2077	9	,	,	PUNCT
fnp-3806	2077	10	mckeel	mckeel	PROPN
fnp-3806	2077	11	dw	dw	PROPN
fnp-3806	2077	12	jr	jr	PROPN
fnp-3806	2077	13	,	,	PUNCT
fnp-3806	2077	14	et	et	PROPN
fnp-3806	2077	15	al	al	PROPN
fnp-3806	2077	16	.	.	PROPN
fnp-3806	2078	1	profound	profound	ADJ
fnp-3806	2078	2	loss	loss	NOUN
fnp-3806	2078	3	of	of	ADP
fnp-3806	2078	4	layer	layer	NOUN
fnp-3806	2078	5	ii	ii	PROPN
fnp-3806	2078	6	entorhinal	entorhinal	ADJ
fnp-3806	2078	7	cortex	cortex	NOUN
fnp-3806	2078	8	neurons	neuron	NOUN
fnp-3806	2078	9	occurs	occur	VERB
fnp-3806	2078	10	in	in	ADP
fnp-3806	2078	11	very	very	ADV
fnp-3806	2078	12	mild	mild	ADJ
fnp-3806	2078	13	alzheimer	alzheimer	NOUN
fnp-3806	2078	14	's	's	PART
fnp-3806	2078	15	disease	disease	NOUN
fnp-3806	2078	16	.	.	PUNCT
fnp-3806	2079	1	j	j	PROPN
fnp-3806	2079	2	neurosci	neurosci	PROPN
fnp-3806	2079	3	1996;16:4491	1996;16:4491	PROPN
fnp-3806	2079	4	-	-	SYM
fnp-3806	2079	5	500	500	NUM
fnp-3806	2079	6	.	.	PUNCT
fnp-3806	2080	1	https://doi.org/10.1523/jneurosci.16-14-04491.1996	https://doi.org/10.1523/jneurosci.16-14-04491.1996	VERB
fnp-3806	2080	2	simić	simić	PROPN
fnp-3806	2080	3	g	g	PROPN
fnp-3806	2080	4	,	,	PUNCT
fnp-3806	2080	5	kostović	kostović	NOUN
fnp-3806	2080	6	i	i	PROPN
fnp-3806	2080	7	,	,	PUNCT
fnp-3806	2080	8	winblad	winblad	PROPN
fnp-3806	2080	9	b	b	NUM
fnp-3806	2080	10	,	,	PUNCT
fnp-3806	2080	11	et	et	PROPN
fnp-3806	2080	12	al	al	PROPN
fnp-3806	2080	13	.	.	PROPN
fnp-3806	2080	14	volume	volume	NOUN
fnp-3806	2080	15	and	and	CCONJ
fnp-3806	2080	16	number	number	NOUN
fnp-3806	2080	17	of	of	ADP
fnp-3806	2080	18	neurons	neuron	NOUN
fnp-3806	2080	19	of	of	ADP
fnp-3806	2080	20	the	the	DET
fnp-3806	2080	21	human	human	ADJ
fnp-3806	2080	22	hippocampal	hippocampal	ADJ
fnp-3806	2080	23	formation	formation	NOUN
fnp-3806	2080	24	in	in	ADP
fnp-3806	2080	25	normal	normal	ADJ
fnp-3806	2080	26	aging	aging	NOUN
fnp-3806	2080	27	and	and	CCONJ
fnp-3806	2080	28	alzheimer	alzheimer	NOUN
fnp-3806	2080	29	's	's	PART
fnp-3806	2080	30	disease	disease	NOUN
fnp-3806	2080	31	.	.	PUNCT
fnp-3806	2081	1	j	j	PROPN
fnp-3806	2081	2	comp	comp	PROPN
fnp-3806	2081	3	neurol	neurol	PROPN
fnp-3806	2081	4	1997;379:482	1997;379:482	PROPN
fnp-3806	2081	5	-	-	SYM
fnp-3806	2081	6	494	494	NUM
fnp-3806	2081	7	.	.	PUNCT
fnp-3806	2082	1	https://doi.org/10.1002	https://doi.org/10.1002	PROPN
fnp-3806	2082	2	(	(	PUNCT
fnp-3806	2082	3	sici)1096	sici)1096	NOUN
fnp-3806	2082	4	-	-	PUNCT
fnp-3806	2082	5	9861(19970324)379:4<482::aid	9861(19970324)379:4<482::aid	NUM
fnp-3806	2082	6	-	-	PUNCT
fnp-3806	2082	7	cne2>3.0.co;2	cne2>3.0.co;2	NOUN
fnp-3806	2082	8	-	-	PUNCT
fnp-3806	2082	9	z.	z.	PROPN
fnp-3806	2082	10	braak	braak	PROPN
fnp-3806	2082	11	h	h	PROPN
fnp-3806	2082	12	,	,	PUNCT
fnp-3806	2082	13	braak	braak	PROPN
fnp-3806	2082	14	e.	e.	PROPN
fnp-3806	2082	15	neuropathological	neuropathological	PROPN
fnp-3806	2082	16	stageing	stage	VERB
fnp-3806	2082	17	of	of	ADP
fnp-3806	2082	18	alzheimer	alzheimer	NOUN
fnp-3806	2082	19	-	-	PUNCT
fnp-3806	2082	20	related	relate	VERB
fnp-3806	2082	21	changes	change	NOUN
fnp-3806	2082	22	.	.	PUNCT
fnp-3806	2083	1	acta	acta	PROPN
fnp-3806	2083	2	neuropathol	neuropathol	PROPN
fnp-3806	2083	3	1991	1991	NUM
fnp-3806	2083	4	;	;	PUNCT
fnp-3806	2083	5	82	82	NUM
fnp-3806	2083	6	:	:	SYM
fnp-3806	2083	7	239	239	NUM
fnp-3806	2083	8	-	-	SYM
fnp-3806	2083	9	259	259	NUM
fnp-3806	2083	10	.	.	PUNCT
fnp-3806	2084	1	https://doi.org/10.1007/bf00308809	https://doi.org/10.1007/bf00308809	PRON
fnp-3806	2084	2	braak	braak	PROPN
fnp-3806	2084	3	h	h	PROPN
fnp-3806	2084	4	,	,	PUNCT
fnp-3806	2084	5	braak	braak	PROPN
fnp-3806	2084	6	e.	e.	PROPN
fnp-3806	2084	7	staging	staging	PROPN
fnp-3806	2084	8	of	of	ADP
fnp-3806	2084	9	alzheimer	alzheimer	PROPN
fnp-3806	2084	10	's	's	PART
fnp-3806	2084	11	disease	disease	NOUN
fnp-3806	2084	12	-	-	PUNCT
fnp-3806	2084	13	related	relate	VERB
fnp-3806	2084	14	neurofibrillary	neurofibrillary	ADJ
fnp-3806	2084	15	changes	change	NOUN
fnp-3806	2084	16	.	.	PUNCT
fnp-3806	2085	1	neurobiol	neurobiol	ADJ
fnp-3806	2085	2	aging	age	VERB
fnp-3806	2085	3	1995;16:271	1995;16:271	PROPN
fnp-3806	2085	4	-	-	PUNCT
fnp-3806	2085	5	278	278	NUM
fnp-3806	2085	6	.	.	PUNCT
fnp-3806	2086	1	https://doi.org/10.1016/0197-4580(95)00021-6	https://doi.org/10.1016/0197-4580(95)00021-6	PROPN
fnp-3806	2086	2	braak	braak	PROPN
fnp-3806	2086	3	h	h	NOUN
fnp-3806	2086	4	,	,	PUNCT
fnp-3806	2086	5	alafuzoff	alafuzoff	NOUN
fnp-3806	2087	1	i	i	PRON
fnp-3806	2087	2	,	,	PUNCT
fnp-3806	2087	3	arzberger	arzberger	PROPN
fnp-3806	2087	4	t	t	PROPN
fnp-3806	2087	5	,	,	PUNCT
fnp-3806	2087	6	et	et	PROPN
fnp-3806	2087	7	al	al	PROPN
fnp-3806	2087	8	.	.	PROPN
fnp-3806	2087	9	staging	staging	NOUN
fnp-3806	2087	10	of	of	ADP
fnp-3806	2087	11	alzheimer	alzheimer	PROPN
fnp-3806	2087	12	disease	disease	NOUN
fnp-3806	2087	13	-	-	PUNCT
fnp-3806	2087	14	associated	associate	VERB
fnp-3806	2087	15	neurofibrillary	neurofibrillary	ADJ
fnp-3806	2087	16	pathology	pathology	NOUN
fnp-3806	2087	17	using	use	VERB
fnp-3806	2087	18	paraffin	paraffin	NOUN
fnp-3806	2087	19	sections	section	NOUN
fnp-3806	2087	20	and	and	CCONJ
fnp-3806	2087	21	immunocytochemistry	immunocytochemistry	NOUN
fnp-3806	2087	22	.	.	PUNCT
fnp-3806	2088	1	acta	acta	PROPN
fnp-3806	2088	2	neuropathol	neuropathol	PROPN
fnp-3806	2088	3	2006;112:389	2006;112:389	NUM
fnp-3806	2088	4	-	-	SYM
fnp-3806	2088	5	404	404	NUM
fnp-3806	2088	6	.	.	PUNCT
fnp-3806	2089	1	https://doi.org/10.1007/s00401-006-0127-z	https://doi.org/10.1007/s00401-006-0127-z	PROPN
fnp-3806	2089	2	braak	braak	PROPN
fnp-3806	2089	3	h	h	PROPN
fnp-3806	2089	4	,	,	PUNCT
fnp-3806	2089	5	del	del	PROPN
fnp-3806	2089	6	tredici	tredici	PROPN
fnp-3806	2089	7	k.	k.	PROPN
fnp-3806	2090	1	the	the	DET
fnp-3806	2090	2	pathological	pathological	ADJ
fnp-3806	2090	3	process	process	NOUN
fnp-3806	2090	4	underlying	underlie	VERB
fnp-3806	2090	5	alzheimer	alzheimer	NOUN
fnp-3806	2090	6	's	's	PART
fnp-3806	2090	7	disease	disease	NOUN
fnp-3806	2090	8	in	in	ADP
fnp-3806	2090	9	individuals	individual	NOUN
fnp-3806	2090	10	under	under	ADP
fnp-3806	2090	11	thirty	thirty	NUM
fnp-3806	2090	12	.	.	PUNCT
fnp-3806	2091	1	acta	acta	PROPN
fnp-3806	2091	2	neuropathol	neuropathol	PROPN
fnp-3806	2091	3	2011;121:171	2011;121:171	PROPN
fnp-3806	2091	4	-	-	SYM
fnp-3806	2091	5	181	181	NUM
fnp-3806	2091	6	.	.	PUNCT
fnp-3806	2092	1	https://doi.org/10.1007/s00401-010-0789-4	https://doi.org/10.1007/s00401-010-0789-4	NUM
fnp-3806	2092	2	ferrer	ferrer	PROPN
fnp-3806	2092	3	i.	i.	PROPN
fnp-3806	2092	4	defining	define	VERB
fnp-3806	2092	5	alzheimer	alzheimer	PROPN
fnp-3806	2092	6	as	as	ADP
fnp-3806	2092	7	a	a	DET
fnp-3806	2092	8	common	common	ADJ
fnp-3806	2092	9	age	age	NOUN
fnp-3806	2092	10	-	-	PUNCT
fnp-3806	2092	11	related	relate	VERB
fnp-3806	2092	12	neurodegenerative	neurodegenerative	ADJ
fnp-3806	2092	13	process	process	NOUN
fnp-3806	2092	14	not	not	PART
fnp-3806	2092	15	inevitably	inevitably	ADV
fnp-3806	2092	16	leading	lead	VERB
fnp-3806	2092	17	to	to	ADP
fnp-3806	2092	18	dementia	dementia	NOUN
fnp-3806	2092	19	.	.	PUNCT
fnp-3806	2093	1	prog	prog	PROPN
fnp-3806	2093	2	neurobiol	neurobiol	PROPN
fnp-3806	2093	3	2012	2012	NUM
fnp-3806	2093	4	;	;	PUNCT
fnp-3806	2093	5	97	97	NUM
fnp-3806	2093	6	:	:	SYM
fnp-3806	2093	7	38	38	NUM
fnp-3806	2093	8	-	-	SYM
fnp-3806	2093	9	51	51	NUM
fnp-3806	2093	10	.	.	PUNCT
fnp-3806	2094	1	https://doi.org/10.1016/j.pneurobio	https://doi.org/10.1016/j.pneurobio	NOUN
fnp-3806	2094	2	2012.03.005	2012.03.005	NUM
fnp-3806	2094	3	.	.	PUNCT
fnp-3806	2095	1	tsartsalis	tsartsalis	PROPN
fnp-3806	2095	2	s	s	PROPN
fnp-3806	2095	3	,	,	PUNCT
fnp-3806	2095	4	aikaterini	aikaterini	PROPN
fnp-3806	2095	5	xekardaki	xekardaki	PROPN
fnp-3806	2095	6	a	a	PRON
fnp-3806	2095	7	,	,	PUNCT
fnp-3806	2095	8	hof	hof	PROPN
fnp-3806	2095	9	pr	pr	NOUN
fnp-3806	2095	10	,	,	PUNCT
fnp-3806	2095	11	et	et	PROPN
fnp-3806	2095	12	al	al	PROPN
fnp-3806	2095	13	.	.	PROPN
fnp-3806	2096	1	early	early	ADJ
fnp-3806	2096	2	alzheimer	alzheimer	ADJ
fnp-3806	2096	3	-	-	PUNCT
fnp-3806	2096	4	type	type	NOUN
fnp-3806	2096	5	lesions	lesion	NOUN
fnp-3806	2096	6	in	in	ADP
fnp-3806	2096	7	cognitively	cognitively	ADV
fnp-3806	2096	8	normal	normal	ADJ
fnp-3806	2096	9	subjects	subject	NOUN
fnp-3806	2096	10	.	.	PUNCT
fnp-3806	2097	1	neurobiol	neurobiol	ADJ
fnp-3806	2097	2	aging	age	VERB
fnp-3806	2097	3	2018	2018	NUM
fnp-3806	2097	4	;	;	PUNCT
fnp-3806	2097	5	62	62	NUM
fnp-3806	2097	6	:	:	PUNCT
fnp-3806	2097	7	34	34	NUM
fnp-3806	2097	8	-	-	SYM
fnp-3806	2097	9	44	44	NUM
fnp-3806	2097	10	.	.	PUNCT
fnp-3806	2098	1	https://doi.org/10.1016/j.neurobiolaging.2017.10.002	https://doi.org/10.1016/j.neurobiolaging.2017.10.002	PROPN
fnp-3806	2098	2	nelson	nelson	PROPN
fnp-3806	2098	3	pt	pt	PROPN
fnp-3806	2098	4	,	,	PUNCT
fnp-3806	2098	5	alafuzoff	alafuzoff	NOUN
fnp-3806	2099	1	i	i	PRON
fnp-3806	2099	2	,	,	PUNCT
fnp-3806	2099	3	bigio	bigio	NOUN
fnp-3806	2099	4	eh	eh	INTJ
fnp-3806	2099	5	,	,	PUNCT
fnp-3806	2099	6	et	et	PROPN
fnp-3806	2099	7	al	al	PROPN
fnp-3806	2099	8	.	.	PUNCT
fnp-3806	2099	9	correlation	correlation	NOUN
fnp-3806	2099	10	of	of	ADP
fnp-3806	2099	11	alzheimer	alzheimer	PROPN
fnp-3806	2099	12	disease	disease	PROPN
fnp-3806	2099	13	neuropathologic	neuropathologic	NOUN
fnp-3806	2099	14	changes	change	NOUN
fnp-3806	2099	15	with	with	ADP
fnp-3806	2099	16	cognitive	cognitive	ADJ
fnp-3806	2099	17	status	status	NOUN
fnp-3806	2099	18	:	:	PUNCT
fnp-3806	2099	19	a	a	DET
fnp-3806	2099	20	review	review	NOUN
fnp-3806	2099	21	of	of	ADP
fnp-3806	2099	22	the	the	DET
fnp-3806	2099	23	literature	literature	NOUN
fnp-3806	2099	24	.	.	PUNCT
fnp-3806	2100	1	j	j	PROPN
fnp-3806	2100	2	neuropathol	neuropathol	PROPN
fnp-3806	2100	3	exp	exp	PROPN
fnp-3806	2100	4	neurol	neurol	PROPN
fnp-3806	2100	5	2012	2012	NUM
fnp-3806	2100	6	;	;	PUNCT
fnp-3806	2100	7	71:362	71:362	NUM
fnp-3806	2100	8	-	-	SYM
fnp-3806	2100	9	381	381	NUM
fnp-3806	2100	10	.	.	PUNCT
fnp-3806	2101	1	https://doi.org/10.1097/nen.0b013e31825018f7	https://doi.org/10.1097/nen.0b013e31825018f7	PROPN
fnp-3806	2101	2	liang	liang	PROPN
fnp-3806	2101	3	ws	ws	PROPN
fnp-3806	2101	4	,	,	PUNCT
fnp-3806	2101	5	dunckley	dunckley	PROPN
fnp-3806	2101	6	t	t	PROPN
fnp-3806	2101	7	,	,	PUNCT
fnp-3806	2101	8	beach	beach	PROPN
fnp-3806	2101	9	tg	tg	PROPN
fnp-3806	2101	10	,	,	PUNCT
fnp-3806	2101	11	et	et	PROPN
fnp-3806	2101	12	al	al	PROPN
fnp-3806	2101	13	.	.	PROPN
fnp-3806	2101	14	altered	alter	VERB
fnp-3806	2101	15	neuronal	neuronal	ADJ
fnp-3806	2101	16	gene	gene	NOUN
fnp-3806	2101	17	expression	expression	NOUN
fnp-3806	2101	18	in	in	ADP
fnp-3806	2101	19	brain	brain	NOUN
fnp-3806	2101	20	regions	region	NOUN
fnp-3806	2101	21	differentially	differentially	ADV
fnp-3806	2101	22	affected	affect	VERB
fnp-3806	2101	23	by	by	ADP
fnp-3806	2101	24	alzheimer	alzheimer	PROPN
fnp-3806	2101	25	’s	’s	PART
fnp-3806	2101	26	disease	disease	NOUN
fnp-3806	2101	27	:	:	PUNCT
fnp-3806	2101	28	a	a	DET
fnp-3806	2101	29	reference	reference	NOUN
fnp-3806	2101	30	data	datum	NOUN
fnp-3806	2101	31	set	set	VERB
fnp-3806	2101	32	.	.	PUNCT
fnp-3806	2102	1	physiol	physiol	PROPN
fnp-3806	2102	2	genomics	genomics	PROPN
fnp-3806	2102	3	2008	2008	NUM
fnp-3806	2102	4	;	;	PUNCT
fnp-3806	2102	5	33	33	NUM
fnp-3806	2102	6	:	:	SYM
fnp-3806	2102	7	240	240	NUM
fnp-3806	2102	8	-	-	SYM
fnp-3806	2102	9	256	256	NUM
fnp-3806	2102	10	.	.	PUNCT
fnp-3806	2103	1	https://doi.org/10.1152/physiolgenomics.00242.2007	https://doi.org/10.1152/physiolgenomics.00242.2007	PROPN
fnp-3806	2103	2	murray	murray	VERB
fnp-3806	2103	3	me	i	PRON
fnp-3806	2103	4	,	,	PUNCT
fnp-3806	2103	5	graff	graff	PROPN
fnp-3806	2103	6	-	-	PUNCT
fnp-3806	2103	7	radford	radford	PROPN
fnp-3806	2103	8	nr	nr	PROPN
fnp-3806	2103	9	,	,	PUNCT
fnp-3806	2103	10	ross	ross	PROPN
fnp-3806	2103	11	oa	oa	PROPN
fnp-3806	2103	12	,	,	PUNCT
fnp-3806	2103	13	et	et	PROPN
fnp-3806	2103	14	al	al	PROPN
fnp-3806	2103	15	.	.	PROPN
fnp-3806	2104	1	neuropathologically	neuropathologically	ADV
fnp-3806	2104	2	defined	define	VERB
fnp-3806	2104	3	subtypes	subtype	NOUN
fnp-3806	2104	4	of	of	ADP
fnp-3806	2104	5	alzheimer	alzheimer	PROPN
fnp-3806	2104	6	's	's	PART
fnp-3806	2104	7	disease	disease	NOUN
fnp-3806	2104	8	with	with	ADP
fnp-3806	2104	9	distinct	distinct	ADJ
fnp-3806	2104	10	clinical	clinical	ADJ
fnp-3806	2104	11	characteristics	characteristic	NOUN
fnp-3806	2104	12	:	:	PUNCT
fnp-3806	2104	13	a	a	DET
fnp-3806	2104	14	retrospective	retrospective	ADJ
fnp-3806	2104	15	study	study	NOUN
fnp-3806	2104	16	.	.	PUNCT
fnp-3806	2105	1	lancet	lancet	PROPN
fnp-3806	2105	2	neurol	neurol	PROPN
fnp-3806	2105	3	2011;10:785	2011;10:785	PROPN
fnp-3806	2105	4	-	-	SYM
fnp-3806	2105	5	796	796	NUM
fnp-3806	2105	6	.	.	PUNCT
fnp-3806	2106	1	https://doi.org/10.1016/s1474-4422(11)70156-9	https://doi.org/10.1016/s1474-4422(11)70156-9	PROPN
fnp-3806	2106	2	jellinger	jellinger	PROPN
fnp-3806	2106	3	ka	ka	PROPN
fnp-3806	2106	4	.	.	PROPN
fnp-3806	2107	1	pathobiological	pathobiological	ADJ
fnp-3806	2107	2	subtypes	subtype	NOUN
fnp-3806	2107	3	of	of	ADP
fnp-3806	2107	4	alzheimer	alzheimer	PROPN
fnp-3806	2107	5	disease	disease	NOUN
fnp-3806	2107	6	.	.	PUNCT
fnp-3806	2108	1	dement	dement	PROPN
fnp-3806	2108	2	geriatr	geriatr	PROPN
fnp-3806	2108	3	cogn	cogn	VERB
fnp-3806	2108	4	disord	disord	NOUN
fnp-3806	2108	5	2020a;49:321	2020a;49:321	NOUN
fnp-3806	2108	6	-	-	PUNCT
fnp-3806	2108	7	333	333	NUM
fnp-3806	2108	8	.	.	PUNCT
fnp-3806	2109	1	https://doi.org/10.1159/000508625	https://doi.org/10.1159/000508625	PROPN
fnp-3806	2109	2	grinberg	grinberg	PROPN
fnp-3806	2109	3	lt	lt	PROPN
fnp-3806	2109	4	,	,	PUNCT
fnp-3806	2109	5	rüb	rüb	X
fnp-3806	2109	6	u	u	PROPN
fnp-3806	2109	7	,	,	PUNCT
fnp-3806	2109	8	ferretti	ferretti	PROPN
fnp-3806	2109	9	re	re	PROPN
fnp-3806	2109	10	,	,	PUNCT
fnp-3806	2109	11	et	et	PROPN
fnp-3806	2109	12	al	al	PROPN
fnp-3806	2109	13	.	.	PUNCT
fnp-3806	2110	1	the	the	DET
fnp-3806	2110	2	dorsal	dorsal	NOUN
fnp-3806	2110	3	raphe	raphe	NOUN
fnp-3806	2110	4	nucleus	nucleus	PROPN
fnp-3806	2110	5	shows	show	VERB
fnp-3806	2110	6	phospho	phospho	ADJ
fnp-3806	2110	7	-	-	PUNCT
fnp-3806	2110	8	tau	tau	NOUN
fnp-3806	2110	9	neurofibrillary	neurofibrillary	ADJ
fnp-3806	2110	10	changes	change	NOUN
fnp-3806	2110	11	before	before	ADP
fnp-3806	2110	12	the	the	DET
fnp-3806	2110	13	transentorhinal	transentorhinal	ADJ
fnp-3806	2110	14	region	region	NOUN
fnp-3806	2110	15	in	in	ADP
fnp-3806	2110	16	alzheimer	alzheimer	PROPN
fnp-3806	2110	17	's	's	PART
fnp-3806	2110	18	disease	disease	NOUN
fnp-3806	2110	19	.	.	PUNCT
fnp-3806	2111	1	a	a	DET
fnp-3806	2111	2	precocious	precocious	ADJ
fnp-3806	2111	3	onset	onset	NOUN
fnp-3806	2111	4	?	?	PUNCT
fnp-3806	2112	1	neuropathol	neuropathol	NOUN
fnp-3806	2112	2	appl	appl	PROPN
fnp-3806	2112	3	neurobiol	neurobiol	PROPN
fnp-3806	2112	4	2009;35:406	2009;35:406	PROPN
fnp-3806	2112	5	-	-	NUM
fnp-3806	2112	6	416	416	NUM
fnp-3806	2112	7	.	.	PUNCT
fnp-3806	2113	1	https://doi.org/10.1111/j.1365-2990.2009.00997.x	https://doi.org/10.1111/j.1365-2990.2009.00997.x	PROPN
fnp-3806	2113	2	braak	braak	PROPN
fnp-3806	2113	3	h	h	PROPN
fnp-3806	2113	4	,	,	PUNCT
fnp-3806	2113	5	del	del	PROPN
fnp-3806	2113	6	tredici	tredici	PROPN
fnp-3806	2113	7	k.	k.	PROPN
fnp-3806	2114	1	the	the	DET
fnp-3806	2114	2	preclinical	preclinical	ADJ
fnp-3806	2114	3	phase	phase	NOUN
fnp-3806	2114	4	of	of	ADP
fnp-3806	2114	5	the	the	DET
fnp-3806	2114	6	pathological	pathological	ADJ
fnp-3806	2114	7	process	process	NOUN
fnp-3806	2114	8	underlying	underlie	VERB
fnp-3806	2114	9	sporadic	sporadic	ADJ
fnp-3806	2114	10	alzheimer	alzheimer	NOUN
fnp-3806	2114	11	's	's	PART
fnp-3806	2114	12	disease	disease	NOUN
fnp-3806	2114	13	.	.	PUNCT
fnp-3806	2115	1	brain	brain	NOUN
fnp-3806	2115	2	2015	2015	NUM
fnp-3806	2115	3	;	;	PUNCT
fnp-3806	2115	4	138:2814	138:2814	NUM
fnp-3806	2115	5	-	-	SYM
fnp-3806	2115	6	2833	2833	NUM
fnp-3806	2115	7	.	.	PUNCT
fnp-3806	2116	1	https://doi.org/10.1093/brain/awv236	https://doi.org/10.1093/brain/awv236	PROPN
fnp-3806	2116	2	arendt	arendt	PROPN
fnp-3806	2116	3	t	t	PROPN
fnp-3806	2116	4	,	,	PUNCT
fnp-3806	2116	5	bruckner	bruckner	PROPN
fnp-3806	2116	6	mk	mk	PROPN
fnp-3806	2116	7	,	,	PUNCT
fnp-3806	2116	8	morawski	morawski	PROPN
fnp-3806	2116	9	m	m	PROPN
fnp-3806	2116	10	,	,	PUNCT
fnp-3806	2116	11	et	et	PROPN
fnp-3806	2116	12	al	al	PROPN
fnp-3806	2116	13	.	.	PROPN
fnp-3806	2117	1	early	early	ADJ
fnp-3806	2117	2	neurone	neurone	NOUN
fnp-3806	2117	3	loss	loss	NOUN
fnp-3806	2117	4	in	in	ADP
fnp-3806	2117	5	alzheimer	alzheimer	PROPN
fnp-3806	2117	6	’s	’s	PART
fnp-3806	2117	7	disease	disease	NOUN
fnp-3806	2117	8	:	:	PUNCT
fnp-3806	2117	9	cortical	cortical	ADJ
fnp-3806	2117	10	or	or	CCONJ
fnp-3806	2117	11	subcortical	subcortical	ADJ
fnp-3806	2117	12	?	?	PUNCT
fnp-3806	2118	1	acta	acta	PROPN
fnp-3806	2118	2	neuropathol	neuropathol	PROPN
fnp-3806	2118	3	commun	commun	PROPN
fnp-3806	2118	4	2015	2015	NUM
fnp-3806	2118	5	;	;	PUNCT
fnp-3806	2119	1	3:10	3:10	NUM
fnp-3806	2119	2	.	.	PUNCT
fnp-3806	2119	3	https://doi.org/10.1186/s40478-015-0187-1	https://doi.org/10.1186/s40478-015-0187-1	AUX
fnp-3806	2119	4	andrés	andrés	PROPN
fnp-3806	2119	5	-	-	PUNCT
fnp-3806	2119	6	benito	benito	PROPN
fnp-3806	2119	7	p	p	PROPN
fnp-3806	2119	8	,	,	PUNCT
fnp-3806	2119	9	fernández	fernández	PROPN
fnp-3806	2119	10	-	-	PUNCT
fnp-3806	2119	11	dueñas	dueñas	PROPN
fnp-3806	2119	12	v	v	NOUN
fnp-3806	2119	13	,	,	PUNCT
fnp-3806	2119	14	carmona	carmona	PROPN
fnp-3806	2119	15	m	m	PROPN
fnp-3806	2119	16	,	,	PUNCT
fnp-3806	2119	17	et	et	PROPN
fnp-3806	2119	18	al	al	PROPN
fnp-3806	2119	19	.	.	PUNCT
fnp-3806	2119	20	locus	locus	ADJ
fnp-3806	2119	21	coeruleus	coeruleus	NOUN
fnp-3806	2119	22	at	at	ADP
fnp-3806	2119	23	asymptomatic	asymptomatic	ADJ
fnp-3806	2119	24	early	early	ADJ
fnp-3806	2119	25	and	and	CCONJ
fnp-3806	2119	26	middle	middle	ADJ
fnp-3806	2119	27	braak	braak	NOUN
fnp-3806	2119	28	stages	stage	NOUN
fnp-3806	2119	29	of	of	ADP
fnp-3806	2119	30	neurofibrillary	neurofibrillary	ADJ
fnp-3806	2119	31	tangle	tangle	NOUN
fnp-3806	2119	32	pathology	pathology	NOUN
fnp-3806	2119	33	.	.	PUNCT
fnp-3806	2120	1	neuropathol	neuropathol	PROPN
fnp-3806	2120	2	appl	appl	PROPN
fnp-3806	2120	3	neurobiol	neurobiol	PROPN
fnp-3806	2120	4	2017;43:373	2017;43:373	PROPN
fnp-3806	2120	5	-	-	SYM
fnp-3806	2120	6	392	392	NUM
fnp-3806	2120	7	.	.	PUNCT
fnp-3806	2121	1	https://doi.org/10.1111/nan.12386	https://doi.org/10.1111/nan.12386	PROPN
fnp-3806	2121	2	eser	eser	PROPN
fnp-3806	2121	3	ra	ra	PROPN
fnp-3806	2121	4	,	,	PUNCT
fnp-3806	2121	5	ehrenberg	ehrenberg	PROPN
fnp-3806	2121	6	aj	aj	PROPN
fnp-3806	2121	7	,	,	PUNCT
fnp-3806	2121	8	petersen	petersen	PROPN
fnp-3806	2121	9	c	c	PROPN
fnp-3806	2121	10	,	,	PUNCT
fnp-3806	2121	11	et	et	PROPN
fnp-3806	2121	12	al	al	PROPN
fnp-3806	2121	13	.	.	PROPN
fnp-3806	2121	14	selective	selective	ADJ
fnp-3806	2121	15	vulnerability	vulnerability	NOUN
fnp-3806	2121	16	of	of	ADP
fnp-3806	2121	17	brainstem	brainstem	NOUN
fnp-3806	2121	18	nuclei	nucleus	NOUN
fnp-3806	2121	19	in	in	ADP
fnp-3806	2121	20	distinct	distinct	ADJ
fnp-3806	2121	21	tauopathies	tauopathie	NOUN
fnp-3806	2121	22	:	:	PUNCT
fnp-3806	2121	23	a	a	DET
fnp-3806	2121	24	postmortem	postmortem	NOUN
fnp-3806	2121	25	study	study	NOUN
fnp-3806	2121	26	.	.	PUNCT
fnp-3806	2122	1	j	j	PROPN
fnp-3806	2122	2	neuropathol	neuropathol	PROPN
fnp-3806	2122	3	exp	exp	PROPN
fnp-3806	2122	4	neurol	neurol	PROPN
fnp-3806	2122	5	2018;77:149	2018;77:149	NOUN
fnp-3806	2122	6	-	-	SYM
fnp-3806	2122	7	161	161	NUM
fnp-3806	2122	8	.	.	PUNCT
fnp-3806	2123	1	https://doi.org/10.1093/jnen/nlx113	https://doi.org/10.1093/jnen/nlx113	ADJ
fnp-3806	2123	2	matchett	matchett	NOUN
fnp-3806	2123	3	bj	bj	PROPN
fnp-3806	2123	4	,	,	PUNCT
fnp-3806	2123	5	grinberg	grinberg	PROPN
fnp-3806	2123	6	lt	lt	PROPN
fnp-3806	2123	7	,	,	PUNCT
fnp-3806	2123	8	theofilas	theofilas	NOUN
fnp-3806	2123	9	p	p	X
fnp-3806	2123	10	,	,	PUNCT
fnp-3806	2123	11	et	et	PROPN
fnp-3806	2123	12	al	al	PROPN
fnp-3806	2123	13	.	.	PUNCT
fnp-3806	2124	1	the	the	DET
fnp-3806	2124	2	mechanistic	mechanistic	PROPN
fnp-3806	2124	3	link	link	NOUN
fnp-3806	2124	4	between	between	ADP
fnp-3806	2124	5	selective	selective	ADJ
fnp-3806	2124	6	vulnerability	vulnerability	NOUN
fnp-3806	2124	7	of	of	ADP
fnp-3806	2124	8	the	the	DET
fnp-3806	2124	9	locus	locus	NOUN
fnp-3806	2124	10	ceruleus	ceruleus	NOUN
fnp-3806	2124	11	and	and	CCONJ
fnp-3806	2124	12	neurodegeneration	neurodegeneration	NOUN
fnp-3806	2124	13	in	in	ADP
fnp-3806	2124	14	alzheimer	alzheimer	PROPN
fnp-3806	2124	15	’s	’s	PART
fnp-3806	2124	16	disease	disease	NOUN
fnp-3806	2124	17	.	.	PUNCT
fnp-3806	2125	1	acta	acta	PROPN
fnp-3806	2125	2	neuropathol	neuropathol	PROPN
fnp-3806	2125	3	2021;141:631	2021;141:631	NUM
fnp-3806	2125	4	-	-	SYM
fnp-3806	2125	5	650	650	NUM
fnp-3806	2125	6	.	.	PUNCT
fnp-3806	2126	1	https://doi.org/10.1007/s00401-020-02248-1	https://doi.org/10.1007/s00401-020-02248-1	PROPN
fnp-3806	2127	1	arnold	arnold	PROPN
fnp-3806	2127	2	se	se	PROPN
fnp-3806	2127	3	,	,	PUNCT
fnp-3806	2127	4	hyman	hyman	PROPN
fnp-3806	2127	5	bt	bt	PROPN
fnp-3806	2127	6	,	,	PUNCT
fnp-3806	2127	7	flory	flory	PROPN
fnp-3806	2127	8	j	j	PROPN
fnp-3806	2127	9	,	,	PUNCT
fnp-3806	2127	10	et	et	PROPN
fnp-3806	2127	11	al	al	PROPN
fnp-3806	2127	12	.	.	PUNCT
fnp-3806	2128	1	the	the	DET
fnp-3806	2128	2	topographical	topographical	ADJ
fnp-3806	2128	3	and	and	CCONJ
fnp-3806	2128	4	neuroanatomical	neuroanatomical	ADJ
fnp-3806	2128	5	distribution	distribution	NOUN
fnp-3806	2128	6	of	of	ADP
fnp-3806	2128	7	neurofibrillary	neurofibrillary	ADJ
fnp-3806	2128	8	tangles	tangle	NOUN
fnp-3806	2128	9	and	and	CCONJ
fnp-3806	2128	10	neuritic	neuritic	ADJ
fnp-3806	2128	11	plaques	plaque	NOUN
fnp-3806	2128	12	in	in	ADP
fnp-3806	2128	13	the	the	DET
fnp-3806	2128	14	cerebral	cerebral	ADJ
fnp-3806	2128	15	cortex	cortex	NOUN
fnp-3806	2128	16	of	of	ADP
fnp-3806	2128	17	patients	patient	NOUN
fnp-3806	2128	18	with	with	ADP
fnp-3806	2128	19	alzheimer	alzheimer	PROPN
fnp-3806	2128	20	's	's	PART
fnp-3806	2128	21	disease	disease	NOUN
fnp-3806	2128	22	.	.	PUNCT
fnp-3806	2129	1	cereb	cereb	PROPN
fnp-3806	2129	2	cortex	cortex	NOUN
fnp-3806	2129	3	1991;1:103	1991;1:103	NOUN
fnp-3806	2129	4	-	-	SYM
fnp-3806	2129	5	116	116	NUM
fnp-3806	2129	6	.	.	PUNCT
fnp-3806	2130	1	https://doi.org/10.1093/cercor/1.1.103	https://doi.org/10.1093/cercor/1.1.103	PROPN
fnp-3806	2130	2	ferrer	ferrer	PROPN
fnp-3806	2130	3	i	i	PROPN
fnp-3806	2130	4	,	,	PUNCT
fnp-3806	2130	5	andrés	andrés	PROPN
fnp-3806	2130	6	-	-	PUNCT
fnp-3806	2130	7	benito	benito	PROPN
fnp-3806	2130	8	p.	p.	PROPN
fnp-3806	2130	9	white	white	PROPN
fnp-3806	2130	10	matter	matter	PROPN
fnp-3806	2130	11	alterations	alteration	NOUN
fnp-3806	2130	12	in	in	ADP
fnp-3806	2130	13	alzheimer	alzheimer	PROPN
fnp-3806	2130	14	’s	’s	PART
fnp-3806	2130	15	disease	disease	NOUN
fnp-3806	2130	16	without	without	ADP
fnp-3806	2130	17	concomitant	concomitant	ADJ
fnp-3806	2130	18	pathologies	pathology	NOUN
fnp-3806	2130	19	.	.	PUNCT
fnp-3806	2131	1	neuropathol	neuropathol	PROPN
fnp-3806	2131	2	appl	appl	PROPN
fnp-3806	2131	3	neurobiol	neurobiol	PROPN
fnp-3806	2131	4	2020;46:654	2020;46:654	PROPN
fnp-3806	2131	5	-	-	SYM
fnp-3806	2131	6	672	672	NUM
fnp-3806	2131	7	.	.	PUNCT
fnp-3806	2132	1	https://doi.org/10.1111/nan.12618	https://doi.org/10.1111/nan.12618	PROPN
fnp-3806	2132	2	thal	thal	PROPN
fnp-3806	2132	3	dr	dr	PROPN
fnp-3806	2132	4	,	,	PUNCT
fnp-3806	2132	5	rüb	rüb	PROPN
fnp-3806	2132	6	u	u	PROPN
fnp-3806	2132	7	,	,	PUNCT
fnp-3806	2132	8	orantes	orantes	PROPN
fnp-3806	2132	9	m	m	PROPN
fnp-3806	2132	10	,	,	PUNCT
fnp-3806	2132	11	et	et	PROPN
fnp-3806	2132	12	al	al	PROPN
fnp-3806	2132	13	.	.	PUNCT
fnp-3806	2132	14	phases	phase	NOUN
fnp-3806	2132	15	of	of	ADP
fnp-3806	2132	16	aβ	aβ	NOUN
fnp-3806	2132	17	-	-	PUNCT
fnp-3806	2132	18	deposition	deposition	NOUN
fnp-3806	2132	19	in	in	ADP
fnp-3806	2132	20	the	the	DET
fnp-3806	2132	21	human	human	ADJ
fnp-3806	2132	22	brain	brain	NOUN
fnp-3806	2132	23	and	and	CCONJ
fnp-3806	2132	24	its	its	PRON
fnp-3806	2132	25	relevance	relevance	NOUN
fnp-3806	2132	26	for	for	ADP
fnp-3806	2132	27	the	the	DET
fnp-3806	2132	28	development	development	NOUN
fnp-3806	2132	29	of	of	ADP
fnp-3806	2132	30	ad	ad	NOUN
fnp-3806	2132	31	.	.	PUNCT
fnp-3806	2133	1	neurology	neurology	NOUN
fnp-3806	2133	2	2002;58:1791	2002;58:1791	PROPN
fnp-3806	2133	3	-	-	SYM
fnp-3806	2133	4	1800	1800	NUM
fnp-3806	2133	5	.	.	PUNCT
fnp-3806	2134	1	https://doi.org/10.1212/wnl.58.12.1791	https://doi.org/10.1212/wnl.58.12.1791	PROPN
fnp-3806	2134	2	arnsten	arnsten	PROPN
fnp-3806	2134	3	aft	aft	PROPN
fnp-3806	2134	4	,	,	PUNCT
fnp-3806	2134	5	datta	datta	PROPN
fnp-3806	2134	6	d	d	PROPN
fnp-3806	2134	7	,	,	PUNCT
fnp-3806	2134	8	del	del	PROPN
fnp-3806	2134	9	tredici	tredici	PROPN
fnp-3806	2134	10	k	k	PROPN
fnp-3806	2134	11	,	,	PUNCT
fnp-3806	2135	1	et	et	PROPN
fnp-3806	2135	2	al	al	PROPN
fnp-3806	2135	3	.	.	PROPN
fnp-3806	2135	4	hypothesis	hypothesis	NOUN
fnp-3806	2135	5	:	:	PUNCT
fnp-3806	2135	6	tau	tau	PROPN
fnp-3806	2135	7	pathology	pathology	NOUN
fnp-3806	2135	8	is	be	AUX
fnp-3806	2135	9	an	an	DET
fnp-3806	2135	10	initiating	initiate	VERB
fnp-3806	2135	11	factor	factor	NOUN
fnp-3806	2135	12	in	in	ADP
fnp-3806	2135	13	sporadic	sporadic	ADJ
fnp-3806	2135	14	alzheimer	alzheimer	PROPN
fnp-3806	2135	15	's	's	PART
fnp-3806	2135	16	disease	disease	NOUN
fnp-3806	2135	17	.	.	PUNCT
fnp-3806	2136	1	alzheimers	alzheimers	PROPN
fnp-3806	2136	2	dement	dement	PROPN
fnp-3806	2136	3	2021;17:115	2021;17:115	PROPN
fnp-3806	2136	4	-	-	PUNCT
fnp-3806	2136	5	124	124	NUM
fnp-3806	2136	6	.	.	PUNCT
fnp-3806	2137	1	https://doi.org/10.1002/alz.12192	https://doi.org/10.1002/alz.12192	PROPN
fnp-3806	2137	2	armstrong	armstrong	PROPN
fnp-3806	2137	3	ra	ra	PROPN
fnp-3806	2137	4	,	,	PUNCT
fnp-3806	2137	5	myers	myers	PROPN
fnp-3806	2137	6	d	d	PROPN
fnp-3806	2137	7	,	,	PUNCT
fnp-3806	2137	8	smith	smith	PROPN
fnp-3806	2137	9	cu	cu	PROPN
fnp-3806	2137	10	.	.	PUNCT
fnp-3806	2138	1	the	the	DET
fnp-3806	2138	2	spatial	spatial	ADJ
fnp-3806	2138	3	patterns	pattern	NOUN
fnp-3806	2138	4	of	of	ADP
fnp-3806	2138	5	plaques	plaque	NOUN
fnp-3806	2138	6	and	and	CCONJ
fnp-3806	2138	7	tangles	tangle	NOUN
fnp-3806	2138	8	in	in	ADP
fnp-3806	2138	9	alzheimer	alzheimer	PROPN
fnp-3806	2138	10	's	's	PART
fnp-3806	2138	11	disease	disease	NOUN
fnp-3806	2138	12	do	do	AUX
fnp-3806	2138	13	not	not	PART
fnp-3806	2138	14	support	support	VERB
fnp-3806	2138	15	the	the	DET
fnp-3806	2138	16	'	'	PUNCT
fnp-3806	2138	17	cascade	cascade	NOUN
fnp-3806	2138	18	hypothesis	hypothesis	NOUN
fnp-3806	2138	19	'	'	PUNCT
fnp-3806	2138	20	.	.	PUNCT
fnp-3806	2139	1	dementia	dementia	NOUN
fnp-3806	2139	2	1993;4:16	1993;4:16	NOUN
fnp-3806	2139	3	-	-	PUNCT
fnp-3806	2139	4	20	20	NUM
fnp-3806	2139	5	.	.	PUNCT
fnp-3806	2140	1	https://doi.org/10.1159/000107291	https://doi.org/10.1159/000107291	PROPN
fnp-3806	2140	2	delacourte	delacourte	PROPN
fnp-3806	2140	3	a	a	PRON
fnp-3806	2140	4	,	,	PUNCT
fnp-3806	2140	5	sergeant	sergeant	NOUN
fnp-3806	2140	6	n	n	CCONJ
fnp-3806	2140	7	,	,	PUNCT
fnp-3806	2140	8	champain	champain	PROPN
fnp-3806	2140	9	d	d	PROPN
fnp-3806	2140	10	,	,	PUNCT
fnp-3806	2140	11	et	et	PROPN
fnp-3806	2140	12	al	al	PROPN
fnp-3806	2140	13	.	.	PROPN
fnp-3806	2140	14	nonoverlapping	nonoverlapping	PROPN
fnp-3806	2140	15	but	but	CCONJ
fnp-3806	2140	16	synergetic	synergetic	ADJ
fnp-3806	2140	17	tau	tau	PROPN
fnp-3806	2140	18	and	and	CCONJ
fnp-3806	2140	19	app	app	PROPN
fnp-3806	2140	20	pathologies	pathology	NOUN
fnp-3806	2140	21	in	in	ADP
fnp-3806	2140	22	sporadic	sporadic	ADJ
fnp-3806	2140	23	alzheimer	alzheimer	PROPN
fnp-3806	2140	24	’s	’s	PART
fnp-3806	2140	25	disease	disease	NOUN
fnp-3806	2140	26	.	.	PUNCT
fnp-3806	2141	1	neurology	neurology	NOUN
fnp-3806	2141	2	2002;59:398	2002;59:398	NOUN
fnp-3806	2141	3	-	-	PUNCT
fnp-3806	2141	4	407	407	NUM
fnp-3806	2141	5	.	.	PUNCT
fnp-3806	2142	1	https://doi.org/10.1212/wnl.59.3.398	https://doi.org/10.1212/wnl.59.3.398	PROPN
fnp-3806	2142	2	delacourte	delacourte	PROPN
fnp-3806	2142	3	a.	a.	PROPN
fnp-3806	2142	4	alzheimer	alzheimer	PROPN
fnp-3806	2142	5	’s	’s	PART
fnp-3806	2142	6	disease	disease	NOUN
fnp-3806	2142	7	:	:	PUNCT
fnp-3806	2142	8	a	a	DET
fnp-3806	2142	9	true	true	ADJ
fnp-3806	2142	10	tauopathy	tauopathy	NOUN
fnp-3806	2142	11	fueled	fuel	VERB
fnp-3806	2142	12	by	by	ADP
fnp-3806	2142	13	amyloid	amyloid	NOUN
fnp-3806	2142	14	precursor	precursor	NOUN
fnp-3806	2142	15	protein	protein	NOUN
fnp-3806	2142	16	dysfunction	dysfunction	NOUN
fnp-3806	2142	17	.	.	PUNCT
fnp-3806	2143	1	in	in	ADP
fnp-3806	2143	2	:	:	PUNCT
fnp-3806	2143	3	hanin	hanin	PROPN
fnp-3806	2143	4	i	i	PROPN
fnp-3806	2143	5	,	,	PUNCT
fnp-3806	2143	6	cacabelos	cacabelos	PROPN
fnp-3806	2143	7	r	r	PROPN
fnp-3806	2143	8	,	,	PUNCT
fnp-3806	2143	9	fisher	fisher	PROPN
fnp-3806	2143	10	a	a	DET
fnp-3806	2143	11	(	(	PUNCT
fnp-3806	2143	12	eds	ed	NOUN
fnp-3806	2143	13	)	)	PUNCT
fnp-3806	2143	14	recent	recent	ADJ
fnp-3806	2143	15	progress	progress	NOUN
fnp-3806	2143	16	in	in	ADP
fnp-3806	2143	17	alzheimer	alzheimer	PROPN
fnp-3806	2143	18	’s	’s	PART
fnp-3806	2143	19	and	and	CCONJ
fnp-3806	2143	20	parkinson	parkinson	NOUN
fnp-3806	2143	21	’s	’s	PART
fnp-3806	2143	22	diseases	disease	NOUN
fnp-3806	2143	23	.	.	PUNCT
fnp-3806	2144	1	taylor	taylor	PROPN
fnp-3806	2144	2	&	&	CCONJ
fnp-3806	2144	3	francis	francis	PROPN
fnp-3806	2144	4	new	new	PROPN
fnp-3806	2144	5	york	york	PROPN
fnp-3806	2144	6	,	,	PUNCT
fnp-3806	2144	7	2005	2005	NUM
fnp-3806	2144	8	,	,	PUNCT
fnp-3806	2144	9	pp	pp	ADP
fnp-3806	2144	10	301–307	301–307	NUM
fnp-3806	2144	11	busche	busche	PROPN
fnp-3806	2144	12	ma	ma	PROPN
fnp-3806	2144	13	,	,	PUNCT
fnp-3806	2144	14	hyman	hyman	PROPN
fnp-3806	2144	15	bt	bt	PROPN
fnp-3806	2144	16	.	.	PROPN
fnp-3806	2144	17	synergy	synergy	NOUN
fnp-3806	2144	18	between	between	ADP
fnp-3806	2144	19	amyloid	amyloid	NOUN
fnp-3806	2144	20	-	-	PUNCT
fnp-3806	2144	21	β	β	PROPN
fnp-3806	2144	22	and	and	CCONJ
fnp-3806	2144	23	tau	tau	PROPN
fnp-3806	2144	24	in	in	ADP
fnp-3806	2144	25	alzheimer	alzheimer	PROPN
fnp-3806	2144	26	’s	’s	PART
fnp-3806	2144	27	disease	disease	NOUN
fnp-3806	2144	28	.	.	PUNCT
fnp-3806	2145	1	nat	nat	PROPN
fnp-3806	2145	2	neurosci	neurosci	PROPN
fnp-3806	2145	3	2020;23:1183	2020;23:1183	NUM
fnp-3806	2145	4	-	-	SYM
fnp-3806	2145	5	1193	1193	NUM
fnp-3806	2145	6	.	.	PUNCT
fnp-3806	2146	1	https://doi.org/10.1038/s41593-020-0687-6	https://doi.org/10.1038/s41593-020-0687-6	VERB
fnp-3806	2146	2	mudher	mudher	PROPN
fnp-3806	2146	3	a	a	PRON
fnp-3806	2146	4	,	,	PUNCT
fnp-3806	2146	5	lovestone	lovestone	PROPN
fnp-3806	2146	6	s.	s.	PROPN
fnp-3806	2146	7	alzheimer	alzheimer	PROPN
fnp-3806	2146	8	's	's	PART
fnp-3806	2146	9	disease	disease	NOUN
fnp-3806	2146	10	-	-	PUNCT
fnp-3806	2146	11	do	do	AUX
fnp-3806	2146	12	tauists	tauist	NOUN
fnp-3806	2146	13	and	and	CCONJ
fnp-3806	2146	14	baptists	baptist	NOUN
fnp-3806	2146	15	finally	finally	ADV
fnp-3806	2146	16	shake	shake	VERB
fnp-3806	2146	17	hands	hand	NOUN
fnp-3806	2146	18	?	?	PUNCT
fnp-3806	2147	1	trends	trend	NOUN
fnp-3806	2147	2	neurosci	neurosci	VERB
fnp-3806	2147	3	2002;25:22	2002;25:22	NUM
fnp-3806	2147	4	-	-	SYM
fnp-3806	2147	5	26	26	NUM
fnp-3806	2147	6	.	.	PUNCT
fnp-3806	2148	1	https://doi.org/10.1016/s0166-2236(00)02031-2	https://doi.org/10.1016/s0166-2236(00)02031-2	PROPN
fnp-3806	2148	2	bierer	bierer	PROPN
fnp-3806	2148	3	lm	lm	PROPN
fnp-3806	2148	4	,	,	PUNCT
fnp-3806	2148	5	hof	hof	PROPN
fnp-3806	2148	6	pr	pr	PROPN
fnp-3806	2148	7	,	,	PUNCT
fnp-3806	2148	8	purohit	purohit	PROPN
fnp-3806	2148	9	dp	dp	PROPN
fnp-3806	2148	10	,	,	PUNCT
fnp-3806	2148	11	et	et	PROPN
fnp-3806	2148	12	al	al	PROPN
fnp-3806	2148	13	.	.	PROPN
fnp-3806	2148	14	neocortical	neocortical	ADJ
fnp-3806	2148	15	neurofibrillary	neurofibrillary	ADJ
fnp-3806	2148	16	tangles	tangle	NOUN
fnp-3806	2148	17	correlate	correlate	VERB
fnp-3806	2148	18	with	with	ADP
fnp-3806	2148	19	dementia	dementia	NOUN
fnp-3806	2148	20	severity	severity	NOUN
fnp-3806	2148	21	in	in	ADP
fnp-3806	2148	22	alzheimer	alzheimer	PROPN
fnp-3806	2148	23	's	's	PART
fnp-3806	2148	24	disease	disease	NOUN
fnp-3806	2148	25	.	.	PUNCT
fnp-3806	2149	1	arch	arch	ADJ
fnp-3806	2149	2	neurol	neurol	NOUN
fnp-3806	2149	3	1995;52:81	1995;52:81	NUM
fnp-3806	2149	4	-	-	SYM
fnp-3806	2149	5	88	88	NUM
fnp-3806	2149	6	.	.	PUNCT
fnp-3806	2149	7	https://doi.org/10.1001/archneur.1995	https://doi.org/10.1001/archneur.1995	PROPN
fnp-3806	2149	8	00540250089017	00540250089017	NUM
fnp-3806	2149	9	.	.	PUNCT
fnp-3806	2150	1	bancher	bancher	ADJ
fnp-3806	2150	2	c	c	NOUN
fnp-3806	2150	3	,	,	PUNCT
fnp-3806	2150	4	braak	braak	PROPN
fnp-3806	2150	5	h	h	PROPN
fnp-3806	2150	6	,	,	PUNCT
fnp-3806	2150	7	fischer	fischer	PROPN
fnp-3806	2150	8	p	p	PROPN
fnp-3806	2150	9	,	,	PUNCT
fnp-3806	2150	10	et	et	PROPN
fnp-3806	2150	11	al	al	PROPN
fnp-3806	2150	12	.	.	PUNCT
fnp-3806	2150	13	neuropathological	neuropathological	ADJ
fnp-3806	2150	14	staging	staging	NOUN
fnp-3806	2150	15	of	of	ADP
fnp-3806	2150	16	alzheimers	alzheimer	NOUN
fnp-3806	2150	17	lesions	lesion	NOUN
fnp-3806	2150	18	and	and	CCONJ
fnp-3806	2150	19	intellectual	intellectual	ADJ
fnp-3806	2150	20	status	status	NOUN
fnp-3806	2150	21	in	in	ADP
fnp-3806	2150	22	alzheimer	alzheimer	PROPN
fnp-3806	2150	23	’s	’s	PART
fnp-3806	2150	24	disease	disease	NOUN
fnp-3806	2150	25	and	and	CCONJ
fnp-3806	2150	26	parkinson	parkinson	NOUN
fnp-3806	2150	27	’s	’s	PART
fnp-3806	2150	28	disease	disease	NOUN
fnp-3806	2150	29	patients	patient	NOUN
fnp-3806	2150	30	.	.	PUNCT
fnp-3806	2151	1	neurosci	neurosci	PROPN
fnp-3806	2151	2	lett	lett	PROPN
fnp-3806	2151	3	1993;162:179	1993;162:179	PROPN
fnp-3806	2151	4	-	-	SYM
fnp-3806	2151	5	182	182	NUM
fnp-3806	2151	6	.	.	PUNCT
fnp-3806	2152	1	https://doi.org/10.1016/0304-3940(93)90590-h	https://doi.org/10.1016/0304-3940(93)90590-h	PROPN
fnp-3806	2152	2	hof	hof	PROPN
fnp-3806	2152	3	pr	pr	PROPN
fnp-3806	2152	4	,	,	PUNCT
fnp-3806	2152	5	morrison	morrison	PROPN
fnp-3806	2152	6	jh	jh	PROPN
fnp-3806	2152	7	.	.	PROPN
fnp-3806	2152	8	hippocampal	hippocampal	PROPN
fnp-3806	2152	9	and	and	CCONJ
fnp-3806	2152	10	neocortical	neocortical	ADJ
fnp-3806	2152	11	involvement	involvement	NOUN
fnp-3806	2152	12	in	in	ADP
fnp-3806	2152	13	normal	normal	ADJ
fnp-3806	2152	14	brain	brain	NOUN
fnp-3806	2152	15	aging	aging	NOUN
fnp-3806	2152	16	and	and	CCONJ
fnp-3806	2152	17	dementia	dementia	NOUN
fnp-3806	2152	18	:	:	PUNCT
fnp-3806	2152	19	morphological	morphological	ADJ
fnp-3806	2152	20	and	and	CCONJ
fnp-3806	2152	21	neurochemical	neurochemical	ADJ
fnp-3806	2152	22	profile	profile	NOUN
fnp-3806	2152	23	of	of	ADP
fnp-3806	2152	24	the	the	DET
fnp-3806	2152	25	vulnerable	vulnerable	ADJ
fnp-3806	2152	26	circuits	circuit	NOUN
fnp-3806	2152	27	.	.	PUNCT
fnp-3806	2153	1	j	j	PROPN
fnp-3806	2153	2	am	be	AUX
fnp-3806	2153	3	geriatr	geriatr	ADJ
fnp-3806	2153	4	soc	soc	NOUN
fnp-3806	2153	5	1996;44:857	1996;44:857	PROPN
fnp-3806	2153	6	-	-	SYM
fnp-3806	2153	7	864	864	NUM
fnp-3806	2153	8	.	.	PUNCT
fnp-3806	2154	1	https://doi.org/10.1111/j.1532-5415.1996.tb03748.x	https://doi.org/10.1111/j.1532-5415.1996.tb03748.x	PROPN
fnp-3806	2154	2	bancher	bancher	ADJ
fnp-3806	2154	3	c	c	NOUN
fnp-3806	2154	4	,	,	PUNCT
fnp-3806	2154	5	jellinger	jellinger	PROPN
fnp-3806	2154	6	k	k	PROPN
fnp-3806	2154	7	,	,	PUNCT
fnp-3806	2154	8	lassmann	lassmann	PROPN
fnp-3806	2154	9	h	h	PROPN
fnp-3806	2154	10	,	,	PUNCT
fnp-3806	2154	11	et	et	PROPN
fnp-3806	2154	12	al	al	PROPN
fnp-3806	2154	13	.	.	PUNCT
fnp-3806	2155	1	correlations	correlation	NOUN
fnp-3806	2155	2	between	between	ADP
fnp-3806	2155	3	mental	mental	ADJ
fnp-3806	2155	4	state	state	NOUN
fnp-3806	2155	5	and	and	CCONJ
fnp-3806	2155	6	quantitative	quantitative	ADJ
fnp-3806	2155	7	neuropathology	neuropathology	NOUN
fnp-3806	2155	8	in	in	ADP
fnp-3806	2155	9	the	the	DET
fnp-3806	2155	10	vienna	vienna	PROPN
fnp-3806	2155	11	longitudinal	longitudinal	ADJ
fnp-3806	2155	12	study	study	NOUN
fnp-3806	2155	13	on	on	ADP
fnp-3806	2155	14	dementia	dementia	NOUN
fnp-3806	2155	15	.	.	PUNCT
fnp-3806	2156	1	eur	eur	PROPN
fnp-3806	2156	2	arch	arch	PROPN
fnp-3806	2156	3	psychiatry	psychiatry	PROPN
fnp-3806	2156	4	clin	clin	PROPN
fnp-3806	2156	5	neurosci	neurosci	PROPN
fnp-3806	2156	6	1996;246:137	1996;246:137	PROPN
fnp-3806	2156	7	-	-	SYM
fnp-3806	2156	8	146	146	NUM
fnp-3806	2156	9	.	.	PUNCT
fnp-3806	2157	1	https://doi.org/10.1007/bf02189115	https://doi.org/10.1007/bf02189115	PROPN
fnp-3806	2157	2	duyckaerts	duyckaert	NOUN
fnp-3806	2157	3	c	c	PROPN
fnp-3806	2157	4	,	,	PUNCT
fnp-3806	2157	5	bennecib	bennecib	VERB
fnp-3806	2157	6	m	m	PRON
fnp-3806	2157	7	,	,	PUNCT
fnp-3806	2157	8	grignon	grignon	PROPN
fnp-3806	2157	9	y	y	PROPN
fnp-3806	2157	10	,	,	PUNCT
fnp-3806	2157	11	et	et	PROPN
fnp-3806	2157	12	al	al	PROPN
fnp-3806	2157	13	.	.	PUNCT
fnp-3806	2158	1	modeling	model	VERB
fnp-3806	2158	2	the	the	DET
fnp-3806	2158	3	relation	relation	NOUN
fnp-3806	2158	4	between	between	ADP
fnp-3806	2158	5	neurofibrillary	neurofibrillary	ADJ
fnp-3806	2158	6	tangles	tangle	NOUN
fnp-3806	2158	7	and	and	CCONJ
fnp-3806	2158	8	mental	mental	ADJ
fnp-3806	2158	9	status	status	NOUN
fnp-3806	2158	10	.	.	PUNCT
fnp-3806	2159	1	neurobiol	neurobiol	PROPN
fnp-3806	2159	2	aging	age	VERB
fnp-3806	2159	3	1997;18:267	1997;18:267	NUM
fnp-3806	2159	4	-	-	PUNCT
fnp-3806	2159	5	273	273	NUM
fnp-3806	2159	6	.	.	PUNCT
fnp-3806	2160	1	https://doi.org/10.1016/s0197-4580(97)80306-5	https://doi.org/10.1016/s0197-4580(97)80306-5	PROPN
fnp-3806	2160	2	haroutunian	haroutunian	PROPN
fnp-3806	2160	3	v	v	PROPN
fnp-3806	2160	4	,	,	PUNCT
fnp-3806	2160	5	purohit	purohit	PROPN
fnp-3806	2160	6	dp	dp	PROPN
fnp-3806	2160	7	,	,	PUNCT
fnp-3806	2160	8	perl	perl	NOUN
fnp-3806	2160	9	dp	dp	NOUN
fnp-3806	2160	10	,	,	PUNCT
fnp-3806	2160	11	et	et	PROPN
fnp-3806	2160	12	al	al	PROPN
fnp-3806	2160	13	.	.	PROPN
fnp-3806	2160	14	neurofibrillary	neurofibrillary	ADJ
fnp-3806	2160	15	tangles	tangle	NOUN
fnp-3806	2160	16	in	in	ADP
fnp-3806	2160	17	nondemented	nondemented	ADJ
fnp-3806	2160	18	elderly	elderly	ADJ
fnp-3806	2160	19	subjects	subject	NOUN
fnp-3806	2160	20	and	and	CCONJ
fnp-3806	2160	21	mild	mild	ADJ
fnp-3806	2160	22	alzheimer	alzheimer	NOUN
fnp-3806	2160	23	disease	disease	NOUN
fnp-3806	2160	24	.	.	PUNCT
fnp-3806	2161	1	arch	arch	ADJ
fnp-3806	2161	2	neurol	neurol	PROPN
fnp-3806	2161	3	1999;56:713	1999;56:713	NUM
fnp-3806	2161	4	-	-	SYM
fnp-3806	2161	5	718	718	NUM
fnp-3806	2161	6	.	.	PUNCT
fnp-3806	2162	1	https://doi.org/10.1001/archneur.56.6.713	https://doi.org/10.1001/archneur.56.6.713	PRON
fnp-3806	2162	2	guillozet	guillozet	PROPN
fnp-3806	2162	3	al	al	PROPN
fnp-3806	2162	4	,	,	PUNCT
fnp-3806	2162	5	weintraub	weintraub	PROPN
fnp-3806	2162	6	s	s	PROPN
fnp-3806	2162	7	,	,	PUNCT
fnp-3806	2162	8	mash	mash	NOUN
fnp-3806	2162	9	dc	dc	PROPN
fnp-3806	2162	10	,	,	PUNCT
fnp-3806	2162	11	et	et	PROPN
fnp-3806	2162	12	al	al	PROPN
fnp-3806	2162	13	.	.	PROPN
fnp-3806	2162	14	neurofibrillary	neurofibrillary	ADJ
fnp-3806	2162	15	tangles	tangle	NOUN
fnp-3806	2162	16	,	,	PUNCT
fnp-3806	2162	17	amyloid	amyloid	NOUN
fnp-3806	2162	18	,	,	PUNCT
fnp-3806	2162	19	and	and	CCONJ
fnp-3806	2162	20	memory	memory	NOUN
fnp-3806	2162	21	in	in	ADP
fnp-3806	2162	22	aging	age	VERB
fnp-3806	2162	23	and	and	CCONJ
fnp-3806	2162	24	mild	mild	ADJ
fnp-3806	2162	25	cognitive	cognitive	ADJ
fnp-3806	2162	26	impairment	impairment	NOUN
fnp-3806	2162	27	.	.	PUNCT
fnp-3806	2163	1	arch	arch	ADJ
fnp-3806	2163	2	neurol	neurol	NOUN
fnp-3806	2163	3	2003;60:729	2003;60:729	PROPN
fnp-3806	2163	4	-	-	PUNCT
fnp-3806	2163	5	736	736	NUM
fnp-3806	2163	6	.	.	PUNCT
fnp-3806	2164	1	https://doi.org/10.1001/archneur.60.5.729	https://doi.org/10.1001/archneur.60.5.729	PROPN
fnp-3806	2164	2	giannakopoulos	giannakopoulo	VERB
fnp-3806	2164	3	p	p	PROPN
fnp-3806	2164	4	,	,	PUNCT
fnp-3806	2164	5	herrmann	herrmann	PROPN
fnp-3806	2164	6	fr	fr	PROPN
fnp-3806	2164	7	,	,	PUNCT
fnp-3806	2164	8	bussière	bussière	PROPN
fnp-3806	2164	9	t	t	PROPN
fnp-3806	2164	10	,	,	PUNCT
fnp-3806	2164	11	et	et	PROPN
fnp-3806	2164	12	al	al	PROPN
fnp-3806	2164	13	.	.	PROPN
fnp-3806	2164	14	tangle	tangle	PROPN
fnp-3806	2164	15	and	and	CCONJ
fnp-3806	2164	16	neuron	neuron	NOUN
fnp-3806	2164	17	numbers	number	NOUN
fnp-3806	2164	18	,	,	PUNCT
fnp-3806	2164	19	but	but	CCONJ
fnp-3806	2164	20	not	not	PART
fnp-3806	2164	21	amyloid	amyloid	NOUN
fnp-3806	2164	22	load	load	NOUN
fnp-3806	2164	23	,	,	PUNCT
fnp-3806	2164	24	predict	predict	VERB
fnp-3806	2164	25	cognitive	cognitive	ADJ
fnp-3806	2164	26	status	status	NOUN
fnp-3806	2164	27	in	in	ADP
fnp-3806	2164	28	alzheimer	alzheimer	PROPN
fnp-3806	2164	29	's	's	PART
fnp-3806	2164	30	disease	disease	NOUN
fnp-3806	2164	31	.	.	PUNCT
fnp-3806	2165	1	neurology	neurology	NOUN
fnp-3806	2165	2	2003;60:1495	2003;60:1495	PROPN
fnp-3806	2165	3	-	-	SYM
fnp-3806	2165	4	500	500	NUM
fnp-3806	2165	5	.	.	PUNCT
fnp-3806	2166	1	https://doi.org/10.1212/01.wnl.0000063311.58879.01	https://doi.org/10.1212/01.wnl.0000063311.58879.01	VERB
fnp-3806	2166	2	imhof	imhof	ADJ
fnp-3806	2166	3	a	a	PRON
fnp-3806	2166	4	,	,	PUNCT
fnp-3806	2166	5	kövari	kövari	ADJ
fnp-3806	2166	6	e	e	NOUN
fnp-3806	2166	7	,	,	PUNCT
fnp-3806	2166	8	von	von	PROPN
fnp-3806	2166	9	gunten	gunten	VERB
fnp-3806	2166	10	a	a	PRON
fnp-3806	2166	11	,	,	PUNCT
fnp-3806	2166	12	et	et	PROPN
fnp-3806	2166	13	al	al	PROPN
fnp-3806	2166	14	.	.	PUNCT
fnp-3806	2167	1	morphological	morphological	ADJ
fnp-3806	2167	2	substrates	substrate	NOUN
fnp-3806	2167	3	of	of	ADP
fnp-3806	2167	4	cognitive	cognitive	ADJ
fnp-3806	2167	5	decline	decline	NOUN
fnp-3806	2167	6	in	in	ADP
fnp-3806	2167	7	nonagenarians	nonagenarian	NOUN
fnp-3806	2167	8	and	and	CCONJ
fnp-3806	2167	9	centenarians	centenarian	NOUN
fnp-3806	2167	10	:	:	PUNCT
fnp-3806	2167	11	a	a	DET
fnp-3806	2167	12	new	new	ADJ
fnp-3806	2167	13	paradigm	paradigm	NOUN
fnp-3806	2167	14	?	?	PUNCT
fnp-3806	2168	1	j	j	PROPN
fnp-3806	2168	2	neurol	neurol	PROPN
fnp-3806	2168	3	sci	sci	PROPN
fnp-3806	2168	4	2007;257:72	2007;257:72	PROPN
fnp-3806	2168	5	-	-	SYM
fnp-3806	2168	6	79	79	NUM
fnp-3806	2168	7	.	.	PUNCT
fnp-3806	2169	1	https://doi.org/10.1016/j.jns.2007.01.025	https://doi.org/10.1016/j.jns.2007.01.025	PROPN
fnp-3806	2169	2	hof	hof	PROPN
fnp-3806	2169	3	pr	pr	PROPN
fnp-3806	2169	4	.	.	PUNCT
fnp-3806	2170	1	regional	regional	ADJ
fnp-3806	2170	2	and	and	CCONJ
fnp-3806	2170	3	laminar	laminar	ADJ
fnp-3806	2170	4	patterns	pattern	NOUN
fnp-3806	2170	5	of	of	ADP
fnp-3806	2170	6	selective	selective	ADJ
fnp-3806	2170	7	neuronal	neuronal	ADJ
fnp-3806	2170	8	vulnerability	vulnerability	NOUN
fnp-3806	2170	9	in	in	ADP
fnp-3806	2170	10	alzheimer	alzheimer	PROPN
fnp-3806	2170	11	’s	’s	PART
fnp-3806	2170	12	disease	disease	NOUN
fnp-3806	2170	13	.	.	PUNCT
fnp-3806	2171	1	in	in	ADP
fnp-3806	2171	2	:	:	PUNCT
fnp-3806	2171	3	functional	functional	ADJ
fnp-3806	2171	4	neurobiology	neurobiology	NOUN
fnp-3806	2171	5	of	of	ADP
fnp-3806	2171	6	aging	aging	NOUN
fnp-3806	2171	7	.	.	PUNCT
fnp-3806	2171	8	,	,	PUNCT
fnp-3806	2171	9	hof	hof	PROPN
fnp-3806	2171	10	pr	pr	PROPN
fnp-3806	2171	11	,	,	PUNCT
fnp-3806	2171	12	mobbs	mobbs	PROPN
fnp-3806	2171	13	cv	cv	PROPN
fnp-3806	2171	14	(	(	PUNCT
fnp-3806	2171	15	eds	ed	NOUN
fnp-3806	2171	16	)	)	PUNCT
fnp-3806	2171	17	.	.	PUNCT
fnp-3806	2172	1	academic	academic	ADJ
fnp-3806	2172	2	press	press	NOUN
fnp-3806	2172	3	,	,	PUNCT
fnp-3806	2172	4	new	new	PROPN
fnp-3806	2172	5	york	york	PROPN
fnp-3806	2172	6	,	,	PUNCT
fnp-3806	2172	7	2001:95	2001:95	NUM
fnp-3806	2172	8	-	-	SYM
fnp-3806	2172	9	109	109	NUM
fnp-3806	2172	10	frisoni	frisoni	NOUN
fnp-3806	2172	11	gb	gb	PROPN
fnp-3806	2172	12	,	,	PUNCT
fnp-3806	2172	13	altomare	altomare	PROPN
fnp-3806	2172	14	d	d	PROPN
fnp-3806	2172	15	,	,	PUNCT
fnp-3806	2172	16	thal	thal	PROPN
fnp-3806	2172	17	dr	dr	PROPN
fnp-3806	2172	18	,	,	PUNCT
fnp-3806	2172	19	et	et	PROPN
fnp-3806	2172	20	al	al	PROPN
fnp-3806	2172	21	.	.	PUNCT
fnp-3806	2173	1	the	the	DET
fnp-3806	2173	2	probabilistic	probabilistic	ADJ
fnp-3806	2173	3	model	model	NOUN
fnp-3806	2173	4	of	of	ADP
fnp-3806	2173	5	alzheimer	alzheimer	PROPN
fnp-3806	2173	6	disease	disease	PROPN
fnp-3806	2173	7	:	:	PUNCT
fnp-3806	2173	8	the	the	DET
fnp-3806	2173	9	amyloid	amyloid	NOUN
fnp-3806	2173	10	hypothesis	hypothesis	NOUN
fnp-3806	2173	11	revised	revise	VERB
fnp-3806	2173	12	.	.	PUNCT
fnp-3806	2174	1	nature	nature	PROPN
fnp-3806	2174	2	rev	rev	VERB
fnp-3806	2174	3	neurosci	neurosci	PROPN
fnp-3806	2174	4	2021;23:53	2021;23:53	NOUN
fnp-3806	2174	5	-	-	SYM
fnp-3806	2174	6	66	66	NUM
fnp-3806	2174	7	.	.	PUNCT
fnp-3806	2175	1	https://doi.org/10.1038/s41583-021-00533-w	https://doi.org/10.1038/s41583-021-00533-w	NOUN
fnp-3806	2175	2	price	price	PROPN
fnp-3806	2175	3	dl	dl	PROPN
fnp-3806	2175	4	,	,	PUNCT
fnp-3806	2175	5	martin	martin	PROPN
fnp-3806	2175	6	lj	lj	PROPN
fnp-3806	2175	7	,	,	PUNCT
fnp-3806	2175	8	sisodia	sisodia	PROPN
fnp-3806	2175	9	ss	ss	PROPN
fnp-3806	2175	10	,	,	PUNCT
fnp-3806	2175	11	et	et	PROPN
fnp-3806	2175	12	al	al	PROPN
fnp-3806	2175	13	.	.	PROPN
fnp-3806	2176	1	aged	aged	ADJ
fnp-3806	2176	2	non	non	ADJ
fnp-3806	2176	3	-	-	ADJ
fnp-3806	2176	4	human	human	ADJ
fnp-3806	2176	5	primates	primate	NOUN
fnp-3806	2176	6	:	:	PUNCT
fnp-3806	2176	7	an	an	DET
fnp-3806	2176	8	animal	animal	NOUN
fnp-3806	2176	9	model	model	NOUN
fnp-3806	2176	10	of	of	ADP
fnp-3806	2176	11	age	age	NOUN
fnp-3806	2176	12	-	-	PUNCT
fnp-3806	2176	13	associated	associate	VERB
fnp-3806	2176	14	neurodegenerative	neurodegenerative	ADJ
fnp-3806	2176	15	disease	disease	NOUN
fnp-3806	2176	16	.	.	PUNCT
fnp-3806	2177	1	brain	brain	NOUN
fnp-3806	2177	2	pathol	pathol	NOUN
fnp-3806	2177	3	1991;1	1991;1	NUM
fnp-3806	2177	4	:	:	PUNCT
fnp-3806	2177	5	287	287	NUM
fnp-3806	2177	6	-	-	SYM
fnp-3806	2177	7	296	296	NUM
fnp-3806	2177	8	.	.	PUNCT
fnp-3806	2178	1	https://doi.org/10.1111/j.1750-3639.1991.tb00672.x	https://doi.org/10.1111/j.1750-3639.1991.tb00672.x	PROPN
fnp-3806	2178	2	giannakopoulos	giannakopoulos	PROPN
fnp-3806	2178	3	p	p	NOUN
fnp-3806	2178	4	,	,	PUNCT
fnp-3806	2178	5	silhol	silhol	PROPN
fnp-3806	2178	6	s	s	PROPN
fnp-3806	2178	7	,	,	PUNCT
fnp-3806	2178	8	jallageas	jallageas	PROPN
fnp-3806	2178	9	v	v	NOUN
fnp-3806	2178	10	,	,	PUNCT
fnp-3806	2178	11	et	et	PROPN
fnp-3806	2178	12	al	al	PROPN
fnp-3806	2178	13	.	.	PROPN
fnp-3806	2179	1	quantitative	quantitative	ADJ
fnp-3806	2179	2	analysis	analysis	NOUN
fnp-3806	2179	3	of	of	ADP
fnp-3806	2179	4	tau	tau	PROPN
fnp-3806	2179	5	protein	protein	NOUN
fnp-3806	2179	6	-	-	PUNCT
fnp-3806	2179	7	immunoreactive	immunoreactive	ADJ
fnp-3806	2179	8	accumulations	accumulation	NOUN
fnp-3806	2179	9	and	and	CCONJ
fnp-3806	2179	10	beta	beta	NOUN
fnp-3806	2179	11	-	-	PUNCT
fnp-3806	2179	12	amyloid	amyloid	NOUN
fnp-3806	2179	13	protein	protein	NOUN
fnp-3806	2179	14	deposits	deposit	NOUN
fnp-3806	2179	15	in	in	ADP
fnp-3806	2179	16	the	the	DET
fnp-3806	2179	17	cerebral	cerebral	ADJ
fnp-3806	2179	18	cortex	cortex	NOUN
fnp-3806	2179	19	of	of	ADP
fnp-3806	2179	20	the	the	DET
fnp-3806	2179	21	mouse	mouse	NOUN
fnp-3806	2179	22	lemur	lemur	PROPN
fnp-3806	2179	23	,	,	PUNCT
fnp-3806	2179	24	microcebus	microcebus	PROPN
fnp-3806	2179	25	murinus	murinus	PROPN
fnp-3806	2179	26	.	.	PUNCT
fnp-3806	2180	1	acta	acta	PROPN
fnp-3806	2180	2	neuropathol	neuropathol	PROPN
fnp-3806	2180	3	1997;94:131	1997;94:131	NOUN
fnp-3806	2180	4	-	-	SYM
fnp-3806	2180	5	139	139	NUM
fnp-3806	2180	6	.	.	PUNCT
fnp-3806	2181	1	https://doi.org/10.1007/s004010050684	https://doi.org/10.1007/s004010050684	NUM
fnp-3806	2181	2	head	head	NOUN
fnp-3806	2181	3	e.	e.	PROPN
fnp-3806	2181	4	neurobiology	neurobiology	PROPN
fnp-3806	2181	5	of	of	ADP
fnp-3806	2181	6	the	the	DET
fnp-3806	2181	7	aging	age	VERB
fnp-3806	2181	8	dog	dog	NOUN
fnp-3806	2181	9	.	.	PUNCT
fnp-3806	2182	1	age	age	NOUN
fnp-3806	2182	2	2012;33:485	2012;33:485	PROPN
fnp-3806	2182	3	-	-	PUNCT
fnp-3806	2182	4	496	496	NUM
fnp-3806	2182	5	.	.	PUNCT
fnp-3806	2183	1	https://doi.org/10.1007/s11357-010-9183-3	https://doi.org/10.1007/s11357-010-9183-3	NUM
fnp-3806	2183	2	morelli	morelli	PROPN
fnp-3806	2183	3	l	l	PROPN
fnp-3806	2183	4	,	,	PUNCT
fnp-3806	2183	5	wei	wei	PROPN
fnp-3806	2183	6	l	l	PROPN
fnp-3806	2183	7	,	,	PUNCT
fnp-3806	2183	8	amorim	amorim	VERB
fnp-3806	2183	9	a	a	PRON
fnp-3806	2183	10	,	,	PUNCT
fnp-3806	2183	11	et	et	PROPN
fnp-3806	2183	12	al	al	PROPN
fnp-3806	2183	13	.	.	PUNCT
fnp-3806	2183	14	cerebrovascular	cerebrovascular	ADJ
fnp-3806	2183	15	amyloidosis	amyloidosis	NOUN
fnp-3806	2183	16	in	in	ADP
fnp-3806	2183	17	squirrel	squirrel	NOUN
fnp-3806	2183	18	monkeys	monkey	NOUN
fnp-3806	2183	19	and	and	CCONJ
fnp-3806	2183	20	rhesus	rhesus	NOUN
fnp-3806	2183	21	monkeys	monkey	NOUN
fnp-3806	2183	22	:	:	PUNCT
fnp-3806	2183	23	apolipoprotein	apolipoprotein	VERB
fnp-3806	2183	24	e	e	PROPN
fnp-3806	2183	25	genotype	genotype	PROPN
fnp-3806	2183	26	.	.	PUNCT
fnp-3806	2184	1	febs	febs	PROPN
fnp-3806	2184	2	lett	lett	PROPN
fnp-3806	2184	3	1996	1996	NUM
fnp-3806	2184	4	;	;	PUNCT
fnp-3806	2184	5	379:132	379:132	X
fnp-3806	2184	6	-	-	SYM
fnp-3806	2184	7	134	134	NUM
fnp-3806	2184	8	.	.	PUNCT
fnp-3806	2185	1	https://doi.org/10.1016/0014-5793(95)01491-8	https://doi.org/10.1016/0014-5793(95)01491-8	PROPN
fnp-3806	2185	2	yu	yu	PROPN
fnp-3806	2185	3	ch	ch	PROPN
fnp-3806	2185	4	,	,	PUNCT
fnp-3806	2185	5	song	song	NOUN
fnp-3806	2185	6	gs	gs	PROPN
fnp-3806	2185	7	,	,	PUNCT
fnp-3806	2185	8	yhee	yhee	PROPN
fnp-3806	2185	9	jy	jy	PROPN
fnp-3806	2185	10	,	,	PUNCT
fnp-3806	2185	11	et	et	PROPN
fnp-3806	2185	12	al	al	PROPN
fnp-3806	2185	13	.	.	PROPN
fnp-3806	2186	1	histopathological	histopathological	ADJ
fnp-3806	2186	2	and	and	CCONJ
fnp-3806	2186	3	immunohistochemical	immunohistochemical	ADJ
fnp-3806	2186	4	comparison	comparison	NOUN
fnp-3806	2186	5	of	of	ADP
fnp-3806	2186	6	the	the	DET
fnp-3806	2186	7	brain	brain	NOUN
fnp-3806	2186	8	of	of	ADP
fnp-3806	2186	9	human	human	ADJ
fnp-3806	2186	10	patients	patient	NOUN
fnp-3806	2186	11	with	with	ADP
fnp-3806	2186	12	alzheimer	alzheimer	PROPN
fnp-3806	2186	13	’s	’s	PART
fnp-3806	2186	14	disease	disease	NOUN
fnp-3806	2186	15	and	and	CCONJ
fnp-3806	2186	16	the	the	DET
fnp-3806	2186	17	brain	brain	NOUN
fnp-3806	2186	18	of	of	ADP
fnp-3806	2186	19	aged	aged	ADJ
fnp-3806	2186	20	dogs	dog	NOUN
fnp-3806	2186	21	with	with	ADP
fnp-3806	2186	22	cognitive	cognitive	ADJ
fnp-3806	2186	23	dysfunction	dysfunction	NOUN
fnp-3806	2186	24	.	.	PUNCT
fnp-3806	2187	1	j	j	PROPN
fnp-3806	2187	2	comp	comp	PROPN
fnp-3806	2187	3	pathol	pathol	VERB
fnp-3806	2187	4	2011;145:45	2011;145:45	NUM
fnp-3806	2187	5	-	-	SYM
fnp-3806	2187	6	58	58	NUM
fnp-3806	2187	7	.	.	PUNCT
fnp-3806	2188	1	https://doi.org/10.1016/j.jcpa.2010.11.004	https://doi.org/10.1016/j.jcpa.2010.11.004	NUM
fnp-3806	2188	2	mutsuga	mutsuga	NOUN
fnp-3806	2188	3	m	m	NOUN
fnp-3806	2188	4	,	,	PUNCT
fnp-3806	2188	5	chambers	chambers	PROPN
fnp-3806	2188	6	jk	jk	PROPN
fnp-3806	2188	7	,	,	PUNCT
fnp-3806	2188	8	uchida	uchida	PROPN
fnp-3806	2188	9	k	k	PROPN
fnp-3806	2188	10	,	,	PUNCT
fnp-3806	2188	11	et	et	PROPN
fnp-3806	2188	12	al	al	PROPN
fnp-3806	2188	13	.	.	PUNCT
fnp-3806	2189	1	binding	bind	VERB
fnp-3806	2189	2	of	of	ADP
fnp-3806	2189	3	curcumin	curcumin	NOUN
fnp-3806	2189	4	to	to	ADP
fnp-3806	2189	5	senile	senile	ADJ
fnp-3806	2189	6	plaques	plaque	NOUN
fnp-3806	2189	7	and	and	CCONJ
fnp-3806	2189	8	cerebral	cerebral	ADJ
fnp-3806	2189	9	amyloid	amyloid	NOUN
fnp-3806	2189	10	angiopathy	angiopathy	NOUN
fnp-3806	2189	11	in	in	ADP
fnp-3806	2189	12	the	the	DET
fnp-3806	2189	13	aged	aged	ADJ
fnp-3806	2189	14	brain	brain	NOUN
fnp-3806	2189	15	of	of	ADP
fnp-3806	2189	16	various	various	ADJ
fnp-3806	2189	17	animals	animal	NOUN
fnp-3806	2189	18	and	and	CCONJ
fnp-3806	2189	19	to	to	ADP
fnp-3806	2189	20	neurofibrillary	neurofibrillary	ADJ
fnp-3806	2189	21	tangles	tangle	NOUN
fnp-3806	2189	22	in	in	ADP
fnp-3806	2189	23	alzheimer	alzheimer	PROPN
fnp-3806	2189	24	’s	’s	PART
fnp-3806	2189	25	brain	brain	NOUN
fnp-3806	2189	26	.	.	PUNCT
fnp-3806	2190	1	j	j	PROPN
fnp-3806	2190	2	vet	vet	PROPN
fnp-3806	2190	3	med	me	VERB
fnp-3806	2190	4	sci	sci	PROPN
fnp-3806	2190	5	2012;74:51	2012;74:51	NUM
fnp-3806	2190	6	-	-	SYM
fnp-3806	2190	7	57	57	NUM
fnp-3806	2190	8	.	.	PUNCT
fnp-3806	2191	1	https://doi.org/10.1292/jvms.11-0307	https://doi.org/10.1292/jvms.11-0307	PROPN
fnp-3806	2191	2	finch	finch	PROPN
fnp-3806	2191	3	ce	ce	PROPN
fnp-3806	2191	4	,	,	PUNCT
fnp-3806	2191	5	austad	austad	PROPN
fnp-3806	2191	6	sn	sn	PROPN
fnp-3806	2191	7	.	.	PUNCT
fnp-3806	2191	8	commentary	commentary	NOUN
fnp-3806	2191	9	:	:	PUNCT
fnp-3806	2191	10	is	be	AUX
fnp-3806	2191	11	alzheimer	alzheimer	PROPN
fnp-3806	2191	12	's	's	PART
fnp-3806	2191	13	disease	disease	NOUN
fnp-3806	2191	14	uniquely	uniquely	ADV
fnp-3806	2191	15	human	human	ADJ
fnp-3806	2191	16	?	?	PUNCT
fnp-3806	2192	1	neurobiol	neurobiol	PROPN
fnp-3806	2192	2	aging	age	VERB
fnp-3806	2192	3	2015	2015	NUM
fnp-3806	2192	4	feb;36:553	feb;36:553	NOUN
fnp-3806	2192	5	-	-	SYM
fnp-3806	2192	6	5	5	NUM
fnp-3806	2192	7	.	.	PUNCT
fnp-3806	2192	8	https://doi.org/10.1016/j.neurobiolaging.2014.10.025	https://doi.org/10.1016/j.neurobiolaging.2014.10.025	VERB
fnp-3806	2192	9	languille	languille	ADJ
fnp-3806	2192	10	s	s	PROPN
fnp-3806	2192	11	,	,	PUNCT
fnp-3806	2192	12	blanc	blanc	PROPN
fnp-3806	2192	13	s	s	PROPN
fnp-3806	2192	14	,	,	PUNCT
fnp-3806	2192	15	blin	blin	PROPN
fnp-3806	2192	16	o	o	PROPN
fnp-3806	2192	17	,	,	PUNCT
fnp-3806	2192	18	et	et	PROPN
fnp-3806	2192	19	al	al	PROPN
fnp-3806	2192	20	.	.	PUNCT
fnp-3806	2193	1	the	the	DET
fnp-3806	2193	2	grey	grey	PROPN
fnp-3806	2193	3	mouse	mouse	NOUN
fnp-3806	2193	4	lemur	lemur	NOUN
fnp-3806	2193	5	:	:	PUNCT
fnp-3806	2193	6	a	a	DET
fnp-3806	2193	7	non	non	ADJ
fnp-3806	2193	8	-	-	ADJ
fnp-3806	2193	9	human	human	ADJ
fnp-3806	2193	10	primate	primate	NOUN
fnp-3806	2193	11	model	model	NOUN
fnp-3806	2193	12	for	for	ADP
fnp-3806	2193	13	ageing	age	VERB
fnp-3806	2193	14	studies	study	NOUN
fnp-3806	2193	15	.	.	PUNCT
fnp-3806	2194	1	ageing	age	VERB
fnp-3806	2194	2	res	re	NOUN
fnp-3806	2194	3	rev	rev	PROPN
fnp-3806	2194	4	2012;11:150	2012;11:150	PROPN
fnp-3806	2194	5	-	-	PUNCT
fnp-3806	2194	6	162	162	NUM
fnp-3806	2194	7	.	.	PUNCT
fnp-3806	2195	1	https://doi.org/10.1016/j.arr.2011.07.001	https://doi.org/10.1016/j.arr.2011.07.001	PROPN
fnp-3806	2195	2	pérez	pérez	NOUN
fnp-3806	2195	3	se	se	PROPN
fnp-3806	2195	4	,	,	PUNCT
fnp-3806	2195	5	raghanti	raghanti	PROPN
fnp-3806	2195	6	ma	ma	PROPN
fnp-3806	2195	7	,	,	PUNCT
fnp-3806	2195	8	hof	hof	PROPN
fnp-3806	2195	9	pr	pr	PROPN
fnp-3806	2195	10	,	,	PUNCT
fnp-3806	2196	1	et	et	PROPN
fnp-3806	2196	2	al	al	PROPN
fnp-3806	2196	3	.	.	PROPN
fnp-3806	2196	4	alzheimer	alzheimer	PROPN
fnp-3806	2196	5	's	's	PART
fnp-3806	2196	6	disease	disease	NOUN
fnp-3806	2196	7	pathology	pathology	NOUN
fnp-3806	2196	8	in	in	ADP
fnp-3806	2196	9	the	the	DET
fnp-3806	2196	10	neocortex	neocortex	NOUN
fnp-3806	2196	11	and	and	CCONJ
fnp-3806	2196	12	hippocampus	hippocampus	NOUN
fnp-3806	2196	13	of	of	ADP
fnp-3806	2196	14	the	the	DET
fnp-3806	2196	15	weste.rn	weste.rn	PROPN
fnp-3806	2196	16	lowland	lowland	NOUN
fnp-3806	2196	17	gorilla	gorilla	NOUN
fnp-3806	2196	18	(	(	PUNCT
fnp-3806	2196	19	gorilla	gorilla	NOUN
fnp-3806	2196	20	gorilla	gorilla	NOUN
fnp-3806	2196	21	gorilla	gorilla	NOUN
fnp-3806	2196	22	)	)	PUNCT
fnp-3806	2196	23	.	.	PUNCT
fnp-3806	2197	1	j	j	PROPN
fnp-3806	2197	2	comp	comp	PROPN
fnp-3806	2197	3	neurol	neurol	VERB
fnp-3806	2197	4	2013;521:4318	2013;521:4318	NUM
fnp-3806	2197	5	-	-	SYM
fnp-3806	2197	6	4338	4338	NUM
fnp-3806	2197	7	.	.	PUNCT
fnp-3806	2198	1	https://doi.org/10.1002/cne.23428	https://doi.org/10.1002/cne.23428	NOUN
fnp-3806	2198	2	uchihara	uchihara	PROPN
fnp-3806	2198	3	t	t	PROPN
fnp-3806	2198	4	,	,	PUNCT
fnp-3806	2198	5	endo	endo	PROPN
fnp-3806	2198	6	k	k	NOUN
fnp-3806	2198	7	,	,	PUNCT
fnp-3806	2198	8	kondo	kondo	PROPN
fnp-3806	2198	9	h	h	PROPN
fnp-3806	2198	10	,	,	PUNCT
fnp-3806	2198	11	et	et	PROPN
fnp-3806	2198	12	al	al	PROPN
fnp-3806	2198	13	.	.	PUNCT
fnp-3806	2199	1	tau	tau	PROPN
fnp-3806	2199	2	pathology	pathology	NOUN
fnp-3806	2199	3	in	in	ADP
fnp-3806	2199	4	aged	aged	ADJ
fnp-3806	2199	5	cynomolgus	cynomolgus	ADJ
fnp-3806	2199	6	monkeys	monkey	NOUN
fnp-3806	2199	7	is	be	AUX
fnp-3806	2199	8	progressive	progressive	ADJ
fnp-3806	2199	9	supranuclear	supranuclear	ADJ
fnp-3806	2199	10	palsy	palsy	ADJ
fnp-3806	2199	11	/	/	SYM
fnp-3806	2199	12	corticobasal	corticobasal	NOUN
fnp-3806	2199	13	degeneration	degeneration	NOUN
fnp-3806	2199	14	,	,	PUNCT
fnp-3806	2199	15	but	but	CCONJ
fnp-3806	2199	16	not	not	PART
fnp-3806	2199	17	alzheimer	alzheimer	NOUN
fnp-3806	2199	18	disease	disease	NOUN
fnp-3806	2199	19	-	-	PUNCT
fnp-3806	2199	20	like	like	ADJ
fnp-3806	2199	21	.	.	PUNCT
fnp-3806	2200	1	ultrastructural	ultrastructural	ADJ
fnp-3806	2200	2	mapping	mapping	NOUN
fnp-3806	2200	3	of	of	ADP
fnp-3806	2200	4	tau	tau	PROPN
fnp-3806	2200	5	by	by	ADP
fnp-3806	2200	6	edx	edx	PROPN
fnp-3806	2200	7	.	.	PROPN
fnp-3806	2200	8	acta	acta	PROPN
fnp-3806	2200	9	neuropathol	neuropathol	PROPN
fnp-3806	2200	10	commun	commun	PROPN
fnp-3806	2200	11	2016;4:118	2016;4:118	PROPN
fnp-3806	2200	12	.	.	PUNCT
fnp-3806	2201	1	https://doi.org/10.1186/s40478-016-0385-5	https://doi.org/10.1186/s40478-016-0385-5	PROPN
fnp-3806	2201	2	edler	edler	PROPN
fnp-3806	2201	3	mk	mk	PROPN
fnp-3806	2201	4	,	,	PUNCT
fnp-3806	2201	5	sherwood	sherwood	PROPN
fnp-3806	2201	6	cc	cc	PROPN
fnp-3806	2201	7	,	,	PUNCT
fnp-3806	2201	8	meindl	meindl	NOUN
fnp-3806	2201	9	rs	rs	PROPN
fnp-3806	2201	10	,	,	PUNCT
fnp-3806	2201	11	et	et	PROPN
fnp-3806	2201	12	al	al	PROPN
fnp-3806	2201	13	.	.	PROPN
fnp-3806	2202	1	aged	aged	ADJ
fnp-3806	2202	2	chimpanzees	chimpanzee	NOUN
fnp-3806	2202	3	exhibit	exhibit	VERB
fnp-3806	2202	4	pathologic	pathologic	ADJ
fnp-3806	2202	5	hallmarks	hallmark	NOUN
fnp-3806	2202	6	of	of	ADP
fnp-3806	2202	7	alzheimer	alzheimer	PROPN
fnp-3806	2202	8	's	's	PART
fnp-3806	2202	9	disease	disease	NOUN
fnp-3806	2202	10	.	.	PUNCT
fnp-3806	2203	1	neurobiol	neurobiol	PROPN
fnp-3806	2203	2	aging	age	VERB
fnp-3806	2203	3	2017;59:107	2017;59:107	PROPN
fnp-3806	2203	4	-	-	SYM
fnp-3806	2203	5	120	120	NUM
fnp-3806	2203	6	.	.	PUNCT
fnp-3806	2204	1	https://doi.org/10.1016/j.neurobiolaging.2017.07.006	https://doi.org/10.1016/j.neurobiolaging.2017.07.006	PROPN
fnp-3806	2204	2	takaichi	takaichi	PROPN
fnp-3806	2204	3	y	y	PROPN
fnp-3806	2204	4	,	,	PUNCT
fnp-3806	2204	5	chambers	chambers	PROPN
fnp-3806	2204	6	jk	jk	PROPN
fnp-3806	2204	7	,	,	PUNCT
fnp-3806	2204	8	takahashi	takahashi	PROPN
fnp-3806	2204	9	k	k	PROPN
fnp-3806	2204	10	,	,	PUNCT
fnp-3806	2204	11	et	et	PROPN
fnp-3806	2204	12	al	al	PROPN
fnp-3806	2204	13	.	.	PUNCT
fnp-3806	2204	14	amyloid	amyloid	PROPN
fnp-3806	2204	15	β	β	PROPN
fnp-3806	2204	16	and	and	CCONJ
fnp-3806	2204	17	tau	tau	PROPN
fnp-3806	2204	18	pathology	pathology	NOUN
fnp-3806	2204	19	in	in	ADP
fnp-3806	2204	20	brains	brain	NOUN
fnp-3806	2204	21	of	of	ADP
fnp-3806	2204	22	aged	aged	ADJ
fnp-3806	2204	23	pinniped	pinniped	NOUN
fnp-3806	2204	24	species	specie	NOUN
fnp-3806	2204	25	(	(	PUNCT
fnp-3806	2204	26	sea	sea	NOUN
fnp-3806	2204	27	lion	lion	NOUN
fnp-3806	2204	28	,	,	PUNCT
fnp-3806	2204	29	seal	seal	NOUN
fnp-3806	2204	30	,	,	PUNCT
fnp-3806	2204	31	and	and	CCONJ
fnp-3806	2204	32	walrus	walrus	PROPN
fnp-3806	2204	33	)	)	PUNCT
fnp-3806	2204	34	.	.	PUNCT
fnp-3806	2205	1	amyloid	amyloid	PROPN
fnp-3806	2205	2	β	β	PROPN
fnp-3806	2205	3	and	and	CCONJ
fnp-3806	2205	4	tau	tau	PROPN
fnp-3806	2205	5	pathology	pathology	NOUN
fnp-3806	2205	6	in	in	ADP
fnp-3806	2205	7	brains	brain	NOUN
fnp-3806	2205	8	of	of	ADP
fnp-3806	2205	9	aged	aged	ADJ
fnp-3806	2205	10	pinniped	pinniped	NOUN
fnp-3806	2205	11	species	specie	NOUN
fnp-3806	2205	12	(	(	PUNCT
fnp-3806	2205	13	sea	sea	NOUN
fnp-3806	2205	14	lion	lion	NOUN
fnp-3806	2205	15	,	,	PUNCT
fnp-3806	2205	16	seal	seal	NOUN
fnp-3806	2205	17	,	,	PUNCT
fnp-3806	2205	18	and	and	CCONJ
fnp-3806	2205	19	walrus	walrus	PROPN
fnp-3806	2205	20	)	)	PUNCT
fnp-3806	2205	21	.	.	PUNCT
fnp-3806	2206	1	acta	acta	PROPN
fnp-3806	2206	2	neuropathol	neuropathol	PROPN
fnp-3806	2206	3	commun	commun	PROPN
fnp-3806	2206	4	2021;9:10	2021;9:10	PROPN
fnp-3806	2206	5	.	.	PUNCT
fnp-3806	2207	1	https://doi.org/10.1186/s40478-020-01104-3	https://doi.org/10.1186/s40478-020-01104-3	NUM
fnp-3806	2207	2	schultz	schultz	PROPN
fnp-3806	2207	3	c	c	PROPN
fnp-3806	2207	4	,	,	PUNCT
fnp-3806	2207	5	dehghani	dehghani	PROPN
fnp-3806	2207	6	f	f	PROPN
fnp-3806	2207	7	,	,	PUNCT
fnp-3806	2207	8	hubbard	hubbard	PROPN
fnp-3806	2207	9	gb	gb	PROPN
fnp-3806	2207	10	,	,	PUNCT
fnp-3806	2207	11	et	et	PROPN
fnp-3806	2207	12	al	al	PROPN
fnp-3806	2207	13	.	.	PUNCT
fnp-3806	2207	14	filamentous	filamentous	ADJ
fnp-3806	2207	15	tau	tau	PROPN
fnp-3806	2207	16	pathology	pathology	NOUN
fnp-3806	2207	17	in	in	ADP
fnp-3806	2207	18	nerve	nerve	NOUN
fnp-3806	2207	19	cells	cell	NOUN
fnp-3806	2207	20	,	,	PUNCT
fnp-3806	2207	21	astrocytes	astrocyte	NOUN
fnp-3806	2207	22	,	,	PUNCT
fnp-3806	2207	23	and	and	CCONJ
fnp-3806	2207	24	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	2207	25	of	of	ADP
fnp-3806	2207	26	aged	aged	ADJ
fnp-3806	2207	27	baboons	baboon	NOUN
fnp-3806	2207	28	.	.	PUNCT
fnp-3806	2208	1	j	j	PROPN
fnp-3806	2208	2	neuropathol	neuropathol	PROPN
fnp-3806	2208	3	exp	exp	PROPN
fnp-3806	2208	4	neurol	neurol	PROPN
fnp-3806	2208	5	2000:59:39	2000:59:39	NUM
fnp-3806	2208	6	-	-	SYM
fnp-3806	2208	7	52	52	NUM
fnp-3806	2208	8	.	.	PUNCT
fnp-3806	2209	1	https://doi.org/10.1093/jnen/59.1.39	https://doi.org/10.1093/jnen/59.1.39	NOUN
fnp-3806	2209	2	schultz	schultz	PROPN
fnp-3806	2209	3	c	c	PROPN
fnp-3806	2209	4	,	,	PUNCT
fnp-3806	2209	5	hubbard	hubbard	PROPN
fnp-3806	2209	6	gb	gb	PROPN
fnp-3806	2209	7	,	,	PUNCT
fnp-3806	2209	8	rüb	rüb	X
fnp-3806	2209	9	u	u	NOUN
fnp-3806	2209	10	,	,	PUNCT
fnp-3806	2209	11	et	et	PROPN
fnp-3806	2209	12	al	al	PROPN
fnp-3806	2209	13	.	.	PUNCT
fnp-3806	2209	14	age	age	NOUN
fnp-3806	2209	15	-	-	PUNCT
fnp-3806	2209	16	related	relate	VERB
fnp-3806	2209	17	progression	progression	NOUN
fnp-3806	2209	18	of	of	ADP
fnp-3806	2209	19	tau	tau	PROPN
fnp-3806	2209	20	pathology	pathology	NOUN
fnp-3806	2209	21	in	in	ADP
fnp-3806	2209	22	brains	brain	NOUN
fnp-3806	2209	23	of	of	ADP
fnp-3806	2209	24	baboons	baboon	NOUN
fnp-3806	2209	25	.	.	PUNCT
fnp-3806	2210	1	neurobiol	neurobiol	PROPN
fnp-3806	2210	2	aging	age	VERB
fnp-3806	2210	3	2000;21	2000;21	NUM
fnp-3806	2210	4	:	:	PUNCT
fnp-3806	2210	5	905	905	NUM
fnp-3806	2210	6	-	-	SYM
fnp-3806	2210	7	912	912	NUM
fnp-3806	2210	8	.	.	PUNCT
fnp-3806	2211	1	https://doi.org/10.1016/s0197-4580(00)00176-7	https://doi.org/10.1016/s0197-4580(00)00176-7	PROPN
fnp-3806	2211	2	abdel	abdel	PROPN
fnp-3806	2211	3	rassoul	rassoul	PROPN
fnp-3806	2211	4	r	r	PROPN
fnp-3806	2211	5	,	,	PUNCT
fnp-3806	2211	6	alves	alves	PROPN
fnp-3806	2211	7	s	s	PROPN
fnp-3806	2211	8	,	,	PUNCT
fnp-3806	2211	9	pantesco	pantesco	PROPN
fnp-3806	2211	10	v	v	PROPN
fnp-3806	2211	11	,	,	PUNCT
fnp-3806	2211	12	et	et	PROPN
fnp-3806	2211	13	al	al	PROPN
fnp-3806	2211	14	.	.	PROPN
fnp-3806	2212	1	distinct	distinct	ADJ
fnp-3806	2212	2	transcriptome	transcriptome	ADJ
fnp-3806	2212	3	expression	expression	NOUN
fnp-3806	2212	4	of	of	ADP
fnp-3806	2212	5	the	the	DET
fnp-3806	2212	6	temporal	temporal	ADJ
fnp-3806	2212	7	cortex	cortex	NOUN
fnp-3806	2212	8	of	of	ADP
fnp-3806	2212	9	the	the	DET
fnp-3806	2212	10	primate	primate	NOUN
fnp-3806	2212	11	microcebus	microcebus	NOUN
fnp-3806	2212	12	murinus	murinu	NOUN
fnp-3806	2212	13	during	during	ADP
fnp-3806	2212	14	brain	brain	NOUN
fnp-3806	2212	15	aging	aging	NOUN
fnp-3806	2212	16	versus	versus	ADP
fnp-3806	2212	17	alzheimer	alzheimer	PROPN
fnp-3806	2212	18	’s	’s	PART
fnp-3806	2212	19	disease	disease	NOUN
fnp-3806	2212	20	like	like	ADP
fnp-3806	2212	21	pathology	pathology	NOUN
fnp-3806	2212	22	.	.	PUNCT
fnp-3806	2213	1	plos	plos	PROPN
fnp-3806	2213	2	one	one	NUM
fnp-3806	2213	3	2010;5	2010;5	NUM
fnp-3806	2213	4	:	:	PUNCT
fnp-3806	2213	5	e12770	e12770	VERB
fnp-3806	2213	6	.	.	PUNCT
fnp-3806	2214	1	https://doi.org/10.1371/journal.pone.0012770	https://doi.org/10.1371/journal.pone.0012770	PROPN
fnp-3806	2214	2	edler	edler	PROPN
fnp-3806	2214	3	mk	mk	PROPN
fnp-3806	2214	4	,	,	PUNCT
fnp-3806	2214	5	munger	munger	PROPN
fnp-3806	2214	6	el	el	PROPN
fnp-3806	2214	7	,	,	PUNCT
fnp-3806	2214	8	meindl	meindl	NOUN
fnp-3806	2214	9	rs	rs	PROPN
fnp-3806	2214	10	,	,	PUNCT
fnp-3806	2214	11	et	et	PROPN
fnp-3806	2214	12	al	al	PROPN
fnp-3806	2214	13	.	.	PROPN
fnp-3806	2214	14	neuron	neuron	PROPN
fnp-3806	2214	15	loss	loss	PROPN
fnp-3806	2214	16	associated	associate	VERB
fnp-3806	2214	17	with	with	ADP
fnp-3806	2214	18	age	age	NOUN
fnp-3806	2214	19	but	but	CCONJ
fnp-3806	2214	20	not	not	PART
fnp-3806	2214	21	alzheimer	alzheimer	PROPN
fnp-3806	2214	22	's	's	PART
fnp-3806	2214	23	disease	disease	NOUN
fnp-3806	2214	24	pathology	pathology	NOUN
fnp-3806	2214	25	in	in	ADP
fnp-3806	2214	26	the	the	DET
fnp-3806	2214	27	chimpanzee	chimpanzee	PROPN
fnp-3806	2214	28	brain	brain	NOUN
fnp-3806	2214	29	.	.	PUNCT
fnp-3806	2215	1	philos	philos	PROPN
fnp-3806	2216	1	trans	trans	PROPN
fnp-3806	2216	2	r	r	PROPN
fnp-3806	2216	3	soc	soc	PROPN
fnp-3806	2216	4	lond	lond	PROPN
fnp-3806	2216	5	b	b	PROPN
fnp-3806	2216	6	biol	biol	PROPN
fnp-3806	2216	7	sci	sci	PROPN
fnp-3806	2216	8	2020;375:20190619	2020;375:20190619	NUM
fnp-3806	2216	9	.	.	PUNCT
fnp-3806	2217	1	https://doi.org/10.1098/rstb.2019.0619	https://doi.org/10.1098/rstb.2019.0619	PROPN
fnp-3806	2217	2	head	head	NOUN
fnp-3806	2217	3	e	e	PROPN
fnp-3806	2217	4	,	,	PUNCT
fnp-3806	2217	5	moffat	moffat	PROPN
fnp-3806	2217	6	k	k	PROPN
fnp-3806	2217	7	,	,	PUNCT
fnp-3806	2217	8	das	das	PROPN
fnp-3806	2217	9	p	p	X
fnp-3806	2217	10	,	,	PUNCT
fnp-3806	2217	11	et	et	PROPN
fnp-3806	2217	12	al	al	PROPN
fnp-3806	2217	13	.	.	PUNCT
fnp-3806	2218	1	beta	beta	NOUN
fnp-3806	2218	2	-	-	PUNCT
fnp-3806	2218	3	amyloid	amyloid	NOUN
fnp-3806	2218	4	deposition	deposition	NOUN
fnp-3806	2218	5	and	and	CCONJ
fnp-3806	2218	6	tau	tau	PROPN
fnp-3806	2218	7	phosphorylation	phosphorylation	NOUN
fnp-3806	2218	8	in	in	ADP
fnp-3806	2218	9	clinically	clinically	ADV
fnp-3806	2218	10	characterized	characterize	VERB
fnp-3806	2218	11	aged	aged	ADJ
fnp-3806	2218	12	cats	cat	NOUN
fnp-3806	2218	13	.	.	PUNCT
fnp-3806	2219	1	neurobiol	neurobiol	ADJ
fnp-3806	2219	2	aging	age	VERB
fnp-3806	2219	3	2005;26:749–763	2005;26:749–763	PROPN
fnp-3806	2219	4	.	.	PUNCT
fnp-3806	2220	1	https://doi.org/10.1016/j.neurobiolaging.2004.06.015	https://doi.org/10.1016/j.neurobiolaging.2004.06.015	PROPN
fnp-3806	2220	2	gunn	gunn	PROPN
fnp-3806	2220	3	-	-	PUNCT
fnp-3806	2220	4	moore	moore	PROPN
fnp-3806	2220	5	da	da	PROPN
fnp-3806	2220	6	,	,	PUNCT
fnp-3806	2220	7	mcvee	mcvee	PROPN
fnp-3806	2220	8	j	j	PROPN
fnp-3806	2220	9	,	,	PUNCT
fnp-3806	2220	10	bradshaw	bradshaw	PROPN
fnp-3806	2220	11	jm	jm	PROPN
fnp-3806	2220	12	,	,	PUNCT
fnp-3806	2220	13	et	et	PROPN
fnp-3806	2220	14	al	al	PROPN
fnp-3806	2220	15	.	.	PUNCT
fnp-3806	2220	16	ageing	age	VERB
fnp-3806	2220	17	changes	change	NOUN
fnp-3806	2220	18	in	in	ADP
fnp-3806	2220	19	cat	cat	NOUN
fnp-3806	2220	20	brains	brain	NOUN
fnp-3806	2220	21	demonstrated	demonstrate	VERB
fnp-3806	2220	22	by	by	ADP
fnp-3806	2220	23	β	β	NOUN
fnp-3806	2220	24	-	-	NOUN
fnp-3806	2220	25	amyloid	amyloid	NOUN
fnp-3806	2220	26	and	and	CCONJ
fnp-3806	2220	27	at8	at8	PROPN
fnp-3806	2220	28	-	-	PUNCT
fnp-3806	2220	29	immunoreactive	immunoreactive	ADJ
fnp-3806	2220	30	phosphorylated	phosphorylate	VERB
fnp-3806	2220	31	tau	tau	PROPN
fnp-3806	2220	32	deposits	deposit	NOUN
fnp-3806	2220	33	j	j	PROPN
fnp-3806	2220	34	feline	feline	PROPN
fnp-3806	2220	35	med	med	PROPN
fnp-3806	2220	36	surg	surg	PROPN
fnp-3806	2220	37	2006;8:234	2006;8:234	NUM
fnp-3806	2220	38	-	-	SYM
fnp-3806	2220	39	242	242	NUM
fnp-3806	2220	40	.	.	PUNCT
fnp-3806	2221	1	https://doi.org/10.1016/j.jfms.2006.01.003	https://doi.org/10.1016/j.jfms.2006.01.003	PROPN
fnp-3806	2221	2	chambers	chambers	PROPN
fnp-3806	2221	3	jk	jk	PROPN
fnp-3806	2221	4	,	,	PUNCT
fnp-3806	2221	5	tokuda	tokuda	PRON
fnp-3806	2221	6	t	t	PROPN
fnp-3806	2221	7	,	,	PUNCT
fnp-3806	2221	8	uchida	uchida	PROPN
fnp-3806	2221	9	k	k	PROPN
fnp-3806	2221	10	,	,	PUNCT
fnp-3806	2221	11	et	et	PROPN
fnp-3806	2221	12	al	al	PROPN
fnp-3806	2221	13	.	.	PUNCT
fnp-3806	2222	1	the	the	DET
fnp-3806	2222	2	domestic	domestic	ADJ
fnp-3806	2222	3	cat	cat	NOUN
fnp-3806	2222	4	as	as	ADP
fnp-3806	2222	5	a	a	DET
fnp-3806	2222	6	natural	natural	ADJ
fnp-3806	2222	7	animal	animal	NOUN
fnp-3806	2222	8	model	model	NOUN
fnp-3806	2222	9	of	of	ADP
fnp-3806	2222	10	alzheimer	alzheimer	PROPN
fnp-3806	2222	11	's	's	PART
fnp-3806	2222	12	disease	disease	NOUN
fnp-3806	2222	13	.	.	PUNCT
fnp-3806	2223	1	acta	acta	PROPN
fnp-3806	2223	2	neuropathol	neuropathol	PROPN
fnp-3806	2223	3	commun	commun	PROPN
fnp-3806	2223	4	2015;3:78	2015;3:78	PROPN
fnp-3806	2223	5	.	.	PUNCT
fnp-3806	2224	1	https://doi.org/10.118	https://doi.org/10.118	X
fnp-3806	2224	2	/s40478	/s40478	PROPN
fnp-3806	2224	3	-	-	PUNCT
fnp-3806	2224	4	015	015	NUM
fnp-3806	2224	5	-	-	PUNCT
fnp-3806	2224	6	0258	0258	NUM
fnp-3806	2224	7	-	-	PUNCT
fnp-3806	2224	8	3	3	NUM
fnp-3806	2224	9	.	.	PUNCT
fnp-3806	2224	10	poncelet	poncelet	PROPN
fnp-3806	2224	11	l	l	PROPN
fnp-3806	2224	12	,	,	PUNCT
fnp-3806	2224	13	ando	ando	PROPN
fnp-3806	2224	14	k	k	PROPN
fnp-3806	2224	15	,	,	PUNCT
fnp-3806	2224	16	vergara	vergara	PROPN
fnp-3806	2224	17	c	c	PROPN
fnp-3806	2224	18	,	,	PUNCT
fnp-3806	2224	19	et	et	PROPN
fnp-3806	2224	20	al	al	PROPN
fnp-3806	2224	21	.	.	PUNCT
fnp-3806	2225	1	a	a	DET
fnp-3806	2225	2	4r	4r	NUM
fnp-3806	2225	3	tauopathy	tauopathy	NOUN
fnp-3806	2225	4	develops	develop	VERB
fnp-3806	2225	5	without	without	ADP
fnp-3806	2225	6	amyloid	amyloid	NOUN
fnp-3806	2225	7	deposits	deposit	NOUN
fnp-3806	2225	8	in	in	ADP
fnp-3806	2225	9	aged	aged	ADJ
fnp-3806	2225	10	cat	cat	NOUN
fnp-3806	2225	11	brains	brain	NOUN
fnp-3806	2225	12	.	.	PUNCT
fnp-3806	2226	1	neurobiol	neurobiol	PROPN
fnp-3806	2226	2	aging	age	VERB
fnp-3806	2226	3	2019;81:200e212	2019;81:200e212	NUM
fnp-3806	2226	4	.	.	PUNCT
fnp-3806	2227	1	https://doi.org/10.1016/j.neurobiolaging.2019.05	https://doi.org/10.1016/j.neurobiolaging.2019.05	NOUN
fnp-3806	2227	2	024	024	NUM
fnp-3806	2227	3	.	.	PUNCT
fnp-3806	2227	4	rapoport	rapoport	NOUN
fnp-3806	2227	5	si	si	PROPN
fnp-3806	2227	6	.	.	PROPN
fnp-3806	2227	7	hypothesis	hypothesis	NOUN
fnp-3806	2227	8	:	:	PUNCT
fnp-3806	2227	9	alzheimer	alzheimer	PROPN
fnp-3806	2227	10	's	's	PART
fnp-3806	2227	11	disease	disease	NOUN
fnp-3806	2227	12	is	be	AUX
fnp-3806	2227	13	a	a	DET
fnp-3806	2227	14	phylogenetic	phylogenetic	ADJ
fnp-3806	2227	15	disease	disease	NOUN
fnp-3806	2227	16	.	.	PUNCT
fnp-3806	2228	1	med	med	ADJ
fnp-3806	2228	2	hypotheses	hypothesis	NOUN
fnp-3806	2228	3	1989	1989	NUM
fnp-3806	2228	4	;	;	PUNCT
fnp-3806	2228	5	29	29	NUM
fnp-3806	2228	6	:	:	PUNCT
fnp-3806	2228	7	147	147	NUM
fnp-3806	2228	8	-	-	SYM
fnp-3806	2228	9	150	150	NUM
fnp-3806	2228	10	.	.	PUNCT
fnp-3806	2229	1	https://doi.org/10.1016/0306-9877(89)90185-0	https://doi.org/10.1016/0306-9877(89)90185-0	PROPN
fnp-3806	2229	2	gonatas	gonata	VERB
fnp-3806	2229	3	nk	nk	PROPN
fnp-3806	2229	4	,	,	PUNCT
fnp-3806	2229	5	anderson	anderson	PROPN
fnp-3806	2229	6	w	w	PROPN
fnp-3806	2229	7	,	,	PUNCT
fnp-3806	2229	8	evangelista	evangelista	PROPN
fnp-3806	2229	9	i.	i.	PROPN
fnp-3806	2229	10	the	the	DET
fnp-3806	2229	11	contribution	contribution	NOUN
fnp-3806	2229	12	of	of	ADP
fnp-3806	2229	13	altered	altered	ADJ
fnp-3806	2229	14	synapses	synapsis	NOUN
fnp-3806	2229	15	in	in	ADP
fnp-3806	2229	16	the	the	DET
fnp-3806	2229	17	senile	senile	ADJ
fnp-3806	2229	18	plaques	plaque	NOUN
fnp-3806	2229	19	:	:	PUNCT
fnp-3806	2229	20	an	an	DET
fnp-3806	2229	21	electron	electron	NOUN
fnp-3806	2229	22	microscopic	microscopic	ADJ
fnp-3806	2229	23	study	study	NOUN
fnp-3806	2229	24	in	in	ADP
fnp-3806	2229	25	alzheimer	alzheimer	PROPN
fnp-3806	2229	26	’s	’s	PART
fnp-3806	2229	27	disease	disease	NOUN
fnp-3806	2229	28	.	.	PUNCT
fnp-3806	2230	1	j	j	PROPN
fnp-3806	2230	2	neuropathol	neuropathol	PROPN
fnp-3806	2230	3	exp	exp	PROPN
fnp-3806	2230	4	neurol	neurol	PROPN
fnp-3806	2230	5	1967;26:25	1967;26:25	PROPN
fnp-3806	2230	6	-	-	SYM
fnp-3806	2230	7	39	39	NUM
fnp-3806	2230	8	.	.	PUNCT
fnp-3806	2231	1	https://doi.org/10.1097/00005072-196701000-00003	https://doi.org/10.1097/00005072-196701000-00003	PROPN
fnp-3806	2231	2	scheibel	scheibel	NOUN
fnp-3806	2231	3	me	i	PRON
fnp-3806	2231	4	,	,	PUNCT
fnp-3806	2231	5	lindsay	lindsay	PROPN
fnp-3806	2231	6	rd	rd	PROPN
fnp-3806	2231	7	,	,	PUNCT
fnp-3806	2231	8	tomiyasu	tomiyasu	PROPN
fnp-3806	2231	9	u	u	PROPN
fnp-3806	2231	10	,	,	PUNCT
fnp-3806	2231	11	et	et	PROPN
fnp-3806	2231	12	al	al	PROPN
fnp-3806	2231	13	.	.	PROPN
fnp-3806	2231	14	progressive	progressive	ADJ
fnp-3806	2231	15	dendritic	dendritic	ADJ
fnp-3806	2231	16	changes	change	NOUN
fnp-3806	2231	17	in	in	ADP
fnp-3806	2231	18	aging	age	VERB
fnp-3806	2231	19	human	human	ADJ
fnp-3806	2231	20	cortex	cortex	NOUN
fnp-3806	2231	21	.	.	PUNCT
fnp-3806	2232	1	exp	exp	NOUN
fnp-3806	2232	2	neurol	neurol	PROPN
fnp-3806	2232	3	1975;47:392	1975;47:392	NOUN
fnp-3806	2232	4	-	-	SYM
fnp-3806	2232	5	403	403	NUM
fnp-3806	2232	6	.	.	PUNCT
fnp-3806	2233	1	https://doi.org/10.1016/0014-4886(75)90072-2	https://doi.org/10.1016/0014-4886(75)90072-2	PROPN
fnp-3806	2233	2	buell	buell	PROPN
fnp-3806	2233	3	sj	sj	PROPN
fnp-3806	2233	4	,	,	PUNCT
fnp-3806	2233	5	coleman	coleman	PROPN
fnp-3806	2233	6	pd	pd	PROPN
fnp-3806	2233	7	.	.	PROPN
fnp-3806	2234	1	dendritic	dendritic	ADJ
fnp-3806	2234	2	growth	growth	NOUN
fnp-3806	2234	3	in	in	ADP
fnp-3806	2234	4	the	the	DET
fnp-3806	2234	5	aged	aged	ADJ
fnp-3806	2234	6	human	human	ADJ
fnp-3806	2234	7	brain	brain	NOUN
fnp-3806	2234	8	and	and	CCONJ
fnp-3806	2234	9	failure	failure	NOUN
fnp-3806	2234	10	of	of	ADP
fnp-3806	2234	11	growth	growth	NOUN
fnp-3806	2234	12	in	in	ADP
fnp-3806	2234	13	senile	senile	ADJ
fnp-3806	2234	14	dementia	dementia	NOUN
fnp-3806	2234	15	.	.	PUNCT
fnp-3806	2235	1	science	science	NOUN
fnp-3806	2235	2	1979	1979	NUM
fnp-3806	2235	3	;	;	PUNCT
fnp-3806	2235	4	206:854	206:854	NUM
fnp-3806	2235	5	-	-	SYM
fnp-3806	2235	6	856	856	NUM
fnp-3806	2235	7	.	.	PUNCT
fnp-3806	2236	1	https://doi.org/10.1126/science.493989	https://doi.org/10.1126/science.493989	PROPN
fnp-3806	2236	2	buell	buell	PROPN
fnp-3806	2236	3	sj	sj	PROPN
fnp-3806	2236	4	,	,	PUNCT
fnp-3806	2236	5	coleman	coleman	PROPN
fnp-3806	2236	6	pd	pd	PROPN
fnp-3806	2236	7	.	.	PROPN
fnp-3806	2236	8	quantitative	quantitative	ADJ
fnp-3806	2236	9	evidence	evidence	NOUN
fnp-3806	2236	10	for	for	ADP
fnp-3806	2236	11	selective	selective	ADJ
fnp-3806	2236	12	dendritic	dendritic	ADJ
fnp-3806	2236	13	growth	growth	NOUN
fnp-3806	2236	14	in	in	ADP
fnp-3806	2236	15	normal	normal	ADJ
fnp-3806	2236	16	human	human	ADJ
fnp-3806	2236	17	aging	aging	NOUN
fnp-3806	2236	18	but	but	CCONJ
fnp-3806	2236	19	not	not	PART
fnp-3806	2236	20	in	in	ADP
fnp-3806	2236	21	senile	senile	ADJ
fnp-3806	2236	22	dementia	dementia	NOUN
fnp-3806	2236	23	.	.	PUNCT
fnp-3806	2237	1	brain	brain	NOUN
fnp-3806	2237	2	res	re	NOUN
fnp-3806	2237	3	1981;214:23	1981;214:23	NUM
fnp-3806	2237	4	-	-	SYM
fnp-3806	2237	5	41	41	NUM
fnp-3806	2237	6	.	.	PUNCT
fnp-3806	2238	1	https://doi.org/10.1016/0006-8993(81)90436-4	https://doi.org/10.1016/0006-8993(81)90436-4	PROPN
fnp-3806	2238	2	flood	flood	NOUN
fnp-3806	2238	3	dg	dg	PROPN
fnp-3806	2238	4	,	,	PUNCT
fnp-3806	2238	5	buell	buell	PROPN
fnp-3806	2238	6	sj	sj	PROPN
fnp-3806	2238	7	,	,	PUNCT
fnp-3806	2238	8	defiore	defiore	NOUN
fnp-3806	2238	9	ch	ch	PROPN
fnp-3806	2238	10	,	,	PUNCT
fnp-3806	2238	11	et	et	PROPN
fnp-3806	2238	12	al	al	PROPN
fnp-3806	2238	13	.	.	PUNCT
fnp-3806	2238	14	age	age	NOUN
fnp-3806	2238	15	-	-	PUNCT
fnp-3806	2238	16	related	relate	VERB
fnp-3806	2238	17	dendritic	dendritic	ADJ
fnp-3806	2238	18	growth	growth	NOUN
fnp-3806	2238	19	in	in	ADP
fnp-3806	2238	20	dentate	dentate	ADJ
fnp-3806	2238	21	gyrus	gyrus	NOUN
fnp-3806	2238	22	of	of	ADP
fnp-3806	2238	23	human	human	ADJ
fnp-3806	2238	24	brain	brain	NOUN
fnp-3806	2238	25	is	be	AUX
fnp-3806	2238	26	followed	follow	VERB
fnp-3806	2238	27	by	by	ADP
fnp-3806	2238	28	regression	regression	NOUN
fnp-3806	2238	29	in	in	ADP
fnp-3806	2238	30	the	the	DET
fnp-3806	2238	31	'	'	PUNCT
fnp-3806	2238	32	oldest	old	ADJ
fnp-3806	2238	33	old	old	ADJ
fnp-3806	2238	34	'	'	PUNCT
fnp-3806	2238	35	.	.	PUNCT
fnp-3806	2239	1	brain	brain	NOUN
fnp-3806	2239	2	res	re	NOUN
fnp-3806	2239	3	1985;345:366	1985;345:366	NUM
fnp-3806	2239	4	-	-	SYM
fnp-3806	2239	5	368	368	NUM
fnp-3806	2239	6	.	.	PUNCT
fnp-3806	2240	1	https://doi.org/10.1016/0006-8993(85)91018-2	https://doi.org/10.1016/0006-8993(85)91018-2	NOUN
fnp-3806	2240	2	flood	flood	NOUN
fnp-3806	2240	3	dg	dg	NOUN
fnp-3806	2240	4	,	,	PUNCT
fnp-3806	2240	5	buell	buell	PROPN
fnp-3806	2240	6	sj	sj	PROPN
fnp-3806	2240	7	,	,	PUNCT
fnp-3806	2240	8	horwitz	horwitz	PROPN
fnp-3806	2240	9	gj	gj	PROPN
fnp-3806	2240	10	,	,	PUNCT
fnp-3806	2240	11	et	et	PROPN
fnp-3806	2240	12	al	al	PROPN
fnp-3806	2240	13	.	.	PUNCT
fnp-3806	2241	1	dendritic	dendritic	ADJ
fnp-3806	2241	2	extent	extent	NOUN
fnp-3806	2241	3	in	in	ADP
fnp-3806	2241	4	human	human	ADJ
fnp-3806	2241	5	dentate	dentate	ADJ
fnp-3806	2241	6	gyrus	gyrus	NOUN
fnp-3806	2241	7	granule	granule	NOUN
fnp-3806	2241	8	cells	cell	NOUN
fnp-3806	2241	9	in	in	ADP
fnp-3806	2241	10	normal	normal	ADJ
fnp-3806	2241	11	aging	aging	NOUN
fnp-3806	2241	12	and	and	CCONJ
fnp-3806	2241	13	senile	senile	ADJ
fnp-3806	2241	14	dementia	dementia	NOUN
fnp-3806	2241	15	.	.	PUNCT
fnp-3806	2242	1	brain	brain	NOUN
fnp-3806	2242	2	res	re	NOUN
fnp-3806	2242	3	1987;402:205	1987;402:205	NUM
fnp-3806	2242	4	-	-	SYM
fnp-3806	2242	5	216	216	NUM
fnp-3806	2242	6	.	.	PUNCT
fnp-3806	2243	1	https://doi.org/10.1016/0006-8993(87)90027-8	https://doi.org/10.1016/0006-8993(87)90027-8	PROPN
fnp-3806	2243	2	catalá	catalá	NOUN
fnp-3806	2243	3	i	i	PROPN
fnp-3806	2243	4	,	,	PUNCT
fnp-3806	2243	5	ferrer	ferrer	PROPN
fnp-3806	2243	6	i	i	PROPN
fnp-3806	2243	7	,	,	PUNCT
fnp-3806	2243	8	galofré	galofré	PROPN
fnp-3806	2243	9	e	e	PROPN
fnp-3806	2243	10	,	,	PUNCT
fnp-3806	2243	11	et	et	PROPN
fnp-3806	2243	12	al	al	PROPN
fnp-3806	2243	13	.	.	PROPN
fnp-3806	2243	14	decreased	decrease	VERB
fnp-3806	2243	15	numbers	number	NOUN
fnp-3806	2243	16	of	of	ADP
fnp-3806	2243	17	dendritic	dendritic	ADJ
fnp-3806	2243	18	spines	spine	NOUN
fnp-3806	2243	19	on	on	ADP
fnp-3806	2243	20	cortical	cortical	ADJ
fnp-3806	2243	21	pyramidal	pyramidal	ADJ
fnp-3806	2243	22	neurons	neuron	NOUN
fnp-3806	2243	23	in	in	ADP
fnp-3806	2243	24	dementia	dementia	NOUN
fnp-3806	2243	25	.	.	PUNCT
fnp-3806	2244	1	a	a	DET
fnp-3806	2244	2	quantitative	quantitative	ADJ
fnp-3806	2244	3	golgi	golgi	NOUN
fnp-3806	2244	4	study	study	NOUN
fnp-3806	2244	5	on	on	ADP
fnp-3806	2244	6	biopsy	biopsy	NOUN
fnp-3806	2244	7	samples	sample	NOUN
fnp-3806	2244	8	.	.	PUNCT
fnp-3806	2245	1	hum	hum	PROPN
fnp-3806	2245	2	neurobiol	neurobiol	PROPN
fnp-3806	2245	3	1988;6:255	1988;6:255	PROPN
fnp-3806	2245	4	-	-	SYM
fnp-3806	2245	5	259	259	NUM
fnp-3806	2245	6	.	.	PUNCT
fnp-3806	2246	1	pmid	pmid	NOUN
fnp-3806	2246	2	:	:	PUNCT
fnp-3806	2246	3	3350705	3350705	NUM
fnp-3806	2246	4	.	.	PUNCT
fnp-3806	2247	1	ferrer	ferrer	PROPN
fnp-3806	2247	2	i	i	PRON
fnp-3806	2247	3	,	,	PUNCT
fnp-3806	2247	4	guionnet	guionnet	NOUN
fnp-3806	2247	5	n	n	CCONJ
fnp-3806	2247	6	,	,	PUNCT
fnp-3806	2247	7	cruz	cruz	PROPN
fnp-3806	2247	8	-	-	PUNCT
fnp-3806	2247	9	sánchez	sánchez	PROPN
fnp-3806	2247	10	f	f	PROPN
fnp-3806	2247	11	,	,	PUNCT
fnp-3806	2247	12	et	et	PROPN
fnp-3806	2247	13	al	al	PROPN
fnp-3806	2247	14	.	.	PUNCT
fnp-3806	2247	15	neuronal	neuronal	ADJ
fnp-3806	2247	16	alterations	alteration	NOUN
fnp-3806	2247	17	in	in	ADP
fnp-3806	2247	18	patients	patient	NOUN
fnp-3806	2247	19	with	with	ADP
fnp-3806	2247	20	dementia	dementia	NOUN
fnp-3806	2247	21	:	:	PUNCT
fnp-3806	2247	22	a	a	DET
fnp-3806	2247	23	golgi	golgi	NOUN
fnp-3806	2247	24	study	study	NOUN
fnp-3806	2247	25	on	on	ADP
fnp-3806	2247	26	biopsy	biopsy	NOUN
fnp-3806	2247	27	samples	sample	NOUN
fnp-3806	2247	28	.	.	PUNCT
fnp-3806	2248	1	neurosci	neurosci	PROPN
fnp-3806	2248	2	lett	lett	PROPN
fnp-3806	2248	3	1990;114:11	1990;114:11	PROPN
fnp-3806	2248	4	-	-	SYM
fnp-3806	2248	5	16	16	NUM
fnp-3806	2248	6	.	.	PUNCT
fnp-3806	2249	1	https://doi.org/10.1016/0304-3940(90)90420-e	https://doi.org/10.1016/0304-3940(90)90420-e	PROPN
fnp-3806	2249	2	terry	terry	PROPN
fnp-3806	2249	3	rd	rd	PROPN
fnp-3806	2249	4	,	,	PUNCT
fnp-3806	2249	5	masliah	masliah	PROPN
fnp-3806	2249	6	e	e	PROPN
fnp-3806	2249	7	,	,	PUNCT
fnp-3806	2249	8	salmon	salmon	NOUN
fnp-3806	2249	9	dp	dp	PROPN
fnp-3806	2249	10	,	,	PUNCT
fnp-3806	2249	11	et	et	PROPN
fnp-3806	2249	12	al	al	PROPN
fnp-3806	2249	13	.	.	PUNCT
fnp-3806	2250	1	physical	physical	ADJ
fnp-3806	2250	2	basis	basis	NOUN
fnp-3806	2250	3	of	of	ADP
fnp-3806	2250	4	cognitive	cognitive	ADJ
fnp-3806	2250	5	alterations	alteration	NOUN
fnp-3806	2250	6	in	in	ADP
fnp-3806	2250	7	alzheimer	alzheimer	PROPN
fnp-3806	2250	8	's	's	PART
fnp-3806	2250	9	disease	disease	NOUN
fnp-3806	2250	10	:	:	PUNCT
fnp-3806	2250	11	synapse	synapse	NOUN
fnp-3806	2250	12	loss	loss	NOUN
fnp-3806	2250	13	is	be	AUX
fnp-3806	2250	14	the	the	DET
fnp-3806	2250	15	major	major	ADJ
fnp-3806	2250	16	correlate	correlate	NOUN
fnp-3806	2250	17	of	of	ADP
fnp-3806	2250	18	cognitive	cognitive	ADJ
fnp-3806	2250	19	impairment	impairment	NOUN
fnp-3806	2250	20	.	.	PUNCT
fnp-3806	2251	1	ann	ann	PROPN
fnp-3806	2251	2	neurol	neurol	PROPN
fnp-3806	2251	3	1991;30	1991;30	PROPN
fnp-3806	2251	4	:	:	PUNCT
fnp-3806	2251	5	572	572	NUM
fnp-3806	2251	6	-	-	SYM
fnp-3806	2251	7	580	580	NUM
fnp-3806	2251	8	.	.	PUNCT
fnp-3806	2252	1	https://doi.org/10.1002/ana.410300410	https://doi.org/10.1002/ana.410300410	PROPN
fnp-3806	2252	2	selkoe	selkoe	PROPN
fnp-3806	2252	3	dj	dj	PROPN
fnp-3806	2252	4	.	.	PUNCT
fnp-3806	2253	1	alzheimer	alzheimer	PROPN
fnp-3806	2253	2	's	's	PART
fnp-3806	2253	3	disease	disease	NOUN
fnp-3806	2253	4	is	be	AUX
fnp-3806	2253	5	a	a	DET
fnp-3806	2253	6	synaptic	synaptic	ADJ
fnp-3806	2253	7	failure	failure	NOUN
fnp-3806	2253	8	.	.	PUNCT
fnp-3806	2254	1	science	science	NOUN
fnp-3806	2254	2	2002	2002	NUM
fnp-3806	2254	3	;	;	PUNCT
fnp-3806	2254	4	298:789	298:789	NOUN
fnp-3806	2254	5	-	-	SYM
fnp-3806	2254	6	791	791	NUM
fnp-3806	2254	7	.	.	PUNCT
fnp-3806	2255	1	https://doi.org/10.1126/science.1074069	https://doi.org/10.1126/science.1074069	NOUN
fnp-3806	2255	2	scheff	scheff	PROPN
fnp-3806	2255	3	sw	sw	PROPN
fnp-3806	2255	4	,	,	PUNCT
fnp-3806	2255	5	price	price	NOUN
fnp-3806	2255	6	da	da	X
fnp-3806	2255	7	.	.	PUNCT
fnp-3806	2255	8	synaptic	synaptic	ADJ
fnp-3806	2255	9	pathology	pathology	NOUN
fnp-3806	2255	10	in	in	ADP
fnp-3806	2255	11	alzheimer	alzheimer	PROPN
fnp-3806	2255	12	’s	’s	PART
fnp-3806	2255	13	disease	disease	NOUN
fnp-3806	2255	14	:	:	PUNCT
fnp-3806	2255	15	a	a	DET
fnp-3806	2255	16	review	review	NOUN
fnp-3806	2255	17	of	of	ADP
fnp-3806	2255	18	ultrastructural	ultrastructural	ADJ
fnp-3806	2255	19	studies	study	NOUN
fnp-3806	2255	20	.	.	PUNCT
fnp-3806	2256	1	neurobiol	neurobiol	ADJ
fnp-3806	2256	2	aging	age	VERB
fnp-3806	2256	3	2003;24:1029	2003;24:1029	NUM
fnp-3806	2256	4	-	-	SYM
fnp-3806	2256	5	1046	1046	NUM
fnp-3806	2256	6	.	.	PUNCT
fnp-3806	2257	1	https://doi.org/10.1016/j.neurobiolaging.2003.08.002	https://doi.org/10.1016/j.neurobiolaging.2003.08.002	NOUN
fnp-3806	2257	2	arendt	arendt	PROPN
fnp-3806	2257	3	t.	t.	PROPN
fnp-3806	2257	4	synaptic	synaptic	ADJ
fnp-3806	2257	5	degeneration	degeneration	NOUN
fnp-3806	2257	6	in	in	ADP
fnp-3806	2257	7	alzheimer	alzheimer	PROPN
fnp-3806	2257	8	's	's	PART
fnp-3806	2257	9	disease	disease	NOUN
fnp-3806	2257	10	.	.	PUNCT
fnp-3806	2258	1	acta	acta	PROPN
fnp-3806	2258	2	neuropathol	neuropathol	PROPN
fnp-3806	2258	3	2009;118	2009;118	NUM
fnp-3806	2258	4	:	:	PUNCT
fnp-3806	2258	5	167	167	NUM
fnp-3806	2258	6	-	-	SYM
fnp-3806	2258	7	179	179	NUM
fnp-3806	2258	8	.	.	PUNCT
fnp-3806	2259	1	https://doi.org/10.1007/s00401-009-0536-x	https://doi.org/10.1007/s00401-009-0536-x	PROPN
fnp-3806	2259	2	domínguez	domínguez	NOUN
fnp-3806	2259	3	-	-	PUNCT
fnp-3806	2259	4	álvaro	álvaro	NOUN
fnp-3806	2259	5	m	m	PROPN
fnp-3806	2259	6	,	,	PUNCT
fnp-3806	2259	7	montero	montero	PROPN
fnp-3806	2259	8	-	-	PUNCT
fnp-3806	2259	9	crespo	crespo	PROPN
fnp-3806	2259	10	m	m	PROPN
fnp-3806	2259	11	,	,	PUNCT
fnp-3806	2259	12	blazquez	blazquez	NOUN
fnp-3806	2259	13	-	-	PUNCT
fnp-3806	2259	14	llorca	llorca	NOUN
fnp-3806	2259	15	l	l	NOUN
fnp-3806	2259	16	,	,	PUNCT
fnp-3806	2259	17	et	et	PROPN
fnp-3806	2259	18	al	al	PROPN
fnp-3806	2259	19	.	.	PROPN
fnp-3806	2259	20	three	three	NUM
fnp-3806	2259	21	-	-	PUNCT
fnp-3806	2259	22	dimensional	dimensional	ADJ
fnp-3806	2259	23	analysis	analysis	NOUN
fnp-3806	2259	24	of	of	ADP
fnp-3806	2259	25	synapses	synapsis	NOUN
fnp-3806	2259	26	in	in	ADP
fnp-3806	2259	27	the	the	DET
fnp-3806	2259	28	transentorhinal	transentorhinal	ADJ
fnp-3806	2259	29	cortex	cortex	NOUN
fnp-3806	2259	30	of	of	ADP
fnp-3806	2259	31	alzheimer	alzheimer	PROPN
fnp-3806	2259	32	's	's	PART
fnp-3806	2259	33	disease	disease	NOUN
fnp-3806	2259	34	patients	patient	NOUN
fnp-3806	2259	35	.	.	PUNCT
fnp-3806	2260	1	acta	acta	PROPN
fnp-3806	2260	2	neuropathol	neuropathol	PROPN
fnp-3806	2260	3	commun	commun	PROPN
fnp-3806	2260	4	2018;6:20	2018;6:20	PROPN
fnp-3806	2260	5	.	.	PUNCT
fnp-3806	2261	1	https://doi.org/10.1186/s40478-018-0520-6	https://doi.org/10.1186/s40478-018-0520-6	PROPN
fnp-3806	2261	2	montero	montero	PROPN
fnp-3806	2261	3	-	-	PUNCT
fnp-3806	2261	4	crespo	crespo	PROPN
fnp-3806	2261	5	m	m	PROPN
fnp-3806	2261	6	,	,	PUNCT
fnp-3806	2261	7	domínguez	domínguez	NOUN
fnp-3806	2261	8	-	-	PUNCT
fnp-3806	2261	9	álvaro	álvaro	NOUN
fnp-3806	2261	10	m	m	PROPN
fnp-3806	2261	11	,	,	PUNCT
fnp-3806	2261	12	alonso	alonso	NOUN
fnp-3806	2261	13	-	-	PUNCT
fnp-3806	2261	14	nanclares	nanclare	NOUN
fnp-3806	2261	15	l	l	NOUN
fnp-3806	2261	16	,	,	PUNCT
fnp-3806	2261	17	et	et	PROPN
fnp-3806	2261	18	al	al	PROPN
fnp-3806	2261	19	.	.	PROPN
fnp-3806	2262	1	three	three	NUM
fnp-3806	2262	2	-	-	PUNCT
fnp-3806	2262	3	dimensional	dimensional	ADJ
fnp-3806	2262	4	analysis	analysis	NOUN
fnp-3806	2262	5	of	of	ADP
fnp-3806	2262	6	synaptic	synaptic	ADJ
fnp-3806	2262	7	organization	organization	NOUN
fnp-3806	2262	8	in	in	ADP
fnp-3806	2262	9	the	the	DET
fnp-3806	2262	10	hippocampal	hippocampal	PROPN
fnp-3806	2262	11	ca1	ca1	PROPN
fnp-3806	2262	12	field	field	NOUN
fnp-3806	2262	13	in	in	ADP
fnp-3806	2262	14	alzheimer	alzheimer	PROPN
fnp-3806	2262	15	's	's	PART
fnp-3806	2262	16	disease	disease	NOUN
fnp-3806	2262	17	.	.	PUNCT
fnp-3806	2263	1	brain	brain	NOUN
fnp-3806	2263	2	2021;144:553	2021;144:553	NUM
fnp-3806	2263	3	-	-	SYM
fnp-3806	2263	4	573	573	NUM
fnp-3806	2263	5	.	.	PUNCT
fnp-3806	2264	1	https://doi.org/10.1093/brain/awaa406	https://doi.org/10.1093/brain/awaa406	NOUN
fnp-3806	2264	2	cheibel	cheibel	PROPN
fnp-3806	2264	3	ab	ab	PROPN
fnp-3806	2264	4	,	,	PUNCT
fnp-3806	2264	5	tomiyasu	tomiyasu	PROPN
fnp-3806	2264	6	u.	u.	PROPN
fnp-3806	2264	7	dendritic	dendritic	PROPN
fnp-3806	2264	8	sprouting	sprouting	NOUN
fnp-3806	2264	9	in	in	ADP
fnp-3806	2264	10	alzheimer	alzheimer	PROPN
fnp-3806	2264	11	's	's	PART
fnp-3806	2264	12	presenile	presenile	NOUN
fnp-3806	2264	13	dementia	dementia	NOUN
fnp-3806	2264	14	.	.	PUNCT
fnp-3806	2265	1	exp	exp	NOUN
fnp-3806	2265	2	neurol	neurol	PROPN
fnp-3806	2265	3	1978;60:1	1978;60:1	PROPN
fnp-3806	2265	4	-	-	SYM
fnp-3806	2265	5	8	8	NUM
fnp-3806	2265	6	.	.	PUNCT
fnp-3806	2266	1	https://doi.org/10.1016/0014-4886(78)90164-4	https://doi.org/10.1016/0014-4886(78)90164-4	PROPN
fnp-3806	2266	2	paula	paula	PROPN
fnp-3806	2266	3	-	-	PUNCT
fnp-3806	2266	4	barbosa	barbosa	PROPN
fnp-3806	2266	5	mm	mm	PROPN
fnp-3806	2266	6	,	,	PUNCT
fnp-3806	2266	7	cardoso	cardoso	PROPN
fnp-3806	2266	8	rm	rm	PROPN
fnp-3806	2266	9	,	,	PUNCT
fnp-3806	2266	10	guimaraes	guimaraes	PROPN
fnp-3806	2266	11	ml	ml	PROPN
fnp-3806	2266	12	,	,	PUNCT
fnp-3806	2266	13	et	et	PROPN
fnp-3806	2266	14	al	al	PROPN
fnp-3806	2266	15	.	.	PUNCT
fnp-3806	2267	1	dendritic	dendritic	ADJ
fnp-3806	2267	2	degeneration	degeneration	NOUN
fnp-3806	2267	3	and	and	CCONJ
fnp-3806	2267	4	regrowth	regrowth	NOUN
fnp-3806	2267	5	in	in	ADP
fnp-3806	2267	6	the	the	DET
fnp-3806	2267	7	cerebral	cerebral	ADJ
fnp-3806	2267	8	cortex	cortex	NOUN
fnp-3806	2267	9	of	of	ADP
fnp-3806	2267	10	patients	patient	NOUN
fnp-3806	2267	11	with	with	ADP
fnp-3806	2267	12	alzheimer	alzheimer	PROPN
fnp-3806	2267	13	's	's	PART
fnp-3806	2267	14	disease	disease	NOUN
fnp-3806	2267	15	.	.	PUNCT
fnp-3806	2268	1	j	j	PROPN
fnp-3806	2268	2	neurol	neurol	PROPN
fnp-3806	2268	3	sci	sci	PROPN
fnp-3806	2268	4	1980;45:129	1980;45:129	PROPN
fnp-3806	2268	5	-	-	SYM
fnp-3806	2268	6	134	134	NUM
fnp-3806	2268	7	.	.	PUNCT
fnp-3806	2269	1	https://doi.org/10.1016/s0022-510x(80)80014-1	https://doi.org/10.1016/s0022-510x(80)80014-1	NOUN
fnp-3806	2269	2	probst	probst	PROPN
fnp-3806	2269	3	a	a	PRON
fnp-3806	2269	4	,	,	PUNCT
fnp-3806	2269	5	basler	basler	NOUN
fnp-3806	2269	6	v	v	NOUN
fnp-3806	2269	7	,	,	PUNCT
fnp-3806	2269	8	bron	bron	PROPN
fnp-3806	2269	9	b	b	PROPN
fnp-3806	2269	10	,	,	PUNCT
fnp-3806	2269	11	et	et	PROPN
fnp-3806	2269	12	al	al	PROPN
fnp-3806	2269	13	.	.	PUNCT
fnp-3806	2270	1	neuritic	neuritic	ADJ
fnp-3806	2270	2	plaques	plaque	NOUN
fnp-3806	2270	3	in	in	ADP
fnp-3806	2270	4	senile	senile	ADJ
fnp-3806	2270	5	dementia	dementia	NOUN
fnp-3806	2270	6	of	of	ADP
fnp-3806	2270	7	alzheimer	alzheimer	PROPN
fnp-3806	2270	8	type	type	NOUN
fnp-3806	2270	9	:	:	PUNCT
fnp-3806	2270	10	a	a	DET
fnp-3806	2270	11	golgi	golgi	NOUN
fnp-3806	2270	12	analysis	analysis	NOUN
fnp-3806	2270	13	in	in	ADP
fnp-3806	2270	14	the	the	DET
fnp-3806	2270	15	hippocampal	hippocampal	ADJ
fnp-3806	2270	16	region	region	NOUN
fnp-3806	2270	17	.	.	PUNCT
fnp-3806	2271	1	brain	brain	NOUN
fnp-3806	2271	2	res	re	NOUN
fnp-3806	2271	3	1983;268:249	1983;268:249	NUM
fnp-3806	2271	4	-	-	SYM
fnp-3806	2271	5	254	254	NUM
fnp-3806	2271	6	.	.	PUNCT
fnp-3806	2272	1	https://doi.org/10.1016/0006-8993(83)90490-0	https://doi.org/10.1016/0006-8993(83)90490-0	PROPN
fnp-3806	2272	2	ferrer	ferrer	PROPN
fnp-3806	2272	3	i	i	PROPN
fnp-3806	2272	4	,	,	PUNCT
fnp-3806	2272	5	aymami	aymami	VERB
fnp-3806	2272	6	a	a	PRON
fnp-3806	2272	7	,	,	PUNCT
fnp-3806	2272	8	rovira	rovira	PROPN
fnp-3806	2272	9	a	a	PRON
fnp-3806	2272	10	,	,	PUNCT
fnp-3806	2272	11	et	et	PROPN
fnp-3806	2272	12	al	al	PROPN
fnp-3806	2272	13	.	.	PUNCT
fnp-3806	2273	1	growth	growth	NOUN
fnp-3806	2273	2	of	of	ADP
fnp-3806	2273	3	abnormal	abnormal	ADJ
fnp-3806	2273	4	neurites	neurite	NOUN
fnp-3806	2273	5	in	in	ADP
fnp-3806	2273	6	atypical	atypical	ADJ
fnp-3806	2273	7	alzheimer	alzheimer	PROPN
fnp-3806	2273	8	’s	’s	PART
fnp-3806	2273	9	disease	disease	NOUN
fnp-3806	2273	10	.	.	PUNCT
fnp-3806	2274	1	a	a	DET
fnp-3806	2274	2	study	study	NOUN
fnp-3806	2274	3	with	with	ADP
fnp-3806	2274	4	the	the	DET
fnp-3806	2274	5	golgi	golgi	NOUN
fnp-3806	2274	6	method	method	NOUN
fnp-3806	2274	7	.	.	PUNCT
fnp-3806	2275	1	acta	acta	PROPN
fnp-3806	2275	2	neuropathol	neuropathol	PROPN
fnp-3806	2275	3	1983;59:167	1983;59:167	PROPN
fnp-3806	2275	4	-	-	SYM
fnp-3806	2275	5	170	170	NUM
fnp-3806	2275	6	.	.	PUNCT
fnp-3806	2276	1	https://doi.org/10.1007/bf00703200	https://doi.org/10.1007/bf00703200	PRON
fnp-3806	2276	2	arendt	arendt	PROPN
fnp-3806	2276	3	t	t	PROPN
fnp-3806	2276	4	,	,	PUNCT
fnp-3806	2276	5	zvegintseva	zvegintseva	PROPN
fnp-3806	2276	6	hg	hg	PROPN
fnp-3806	2276	7	,	,	PUNCT
fnp-3806	2276	8	leontovich	leontovich	NOUN
fnp-3806	2276	9	ta	ta	PROPN
fnp-3806	2276	10	.	.	PUNCT
fnp-3806	2277	1	dendritic	dendritic	ADJ
fnp-3806	2277	2	changes	change	NOUN
fnp-3806	2277	3	in	in	ADP
fnp-3806	2277	4	the	the	DET
fnp-3806	2277	5	basal	basal	ADJ
fnp-3806	2277	6	nucleus	nucleus	NOUN
fnp-3806	2277	7	of	of	ADP
fnp-3806	2277	8	meynert	meynert	PROPN
fnp-3806	2277	9	and	and	CCONJ
fnp-3806	2277	10	in	in	ADP
fnp-3806	2277	11	the	the	DET
fnp-3806	2277	12	diagonal	diagonal	ADJ
fnp-3806	2277	13	band	band	NOUN
fnp-3806	2277	14	nucleus	nucleus	NOUN
fnp-3806	2277	15	in	in	ADP
fnp-3806	2277	16	alzheimer	alzheimer	PROPN
fnp-3806	2277	17	's	's	PART
fnp-3806	2277	18	disease	disease	NOUN
fnp-3806	2277	19	--	--	PUNCT
fnp-3806	2277	20	a	a	DET
fnp-3806	2277	21	quantitative	quantitative	ADJ
fnp-3806	2277	22	golgi	golgi	NOUN
fnp-3806	2277	23	investigation	investigation	NOUN
fnp-3806	2277	24	.	.	PUNCT
fnp-3806	2278	1	neuroscience	neuroscience	NOUN
fnp-3806	2278	2	1986;19:1265	1986;19:1265	NUM
fnp-3806	2278	3	-	-	SYM
fnp-3806	2278	4	1278	1278	NUM
fnp-3806	2278	5	.	.	PUNCT
fnp-3806	2279	1	https://doi.org/10.1016/0306-4522(86)90141-7	https://doi.org/10.1016/0306-4522(86)90141-7	VERB
fnp-3806	2279	2	masliah	masliah	PROPN
fnp-3806	2279	3	e	e	PROPN
fnp-3806	2279	4	,	,	PUNCT
fnp-3806	2279	5	mallory	mallory	PROPN
fnp-3806	2279	6	m	m	PROPN
fnp-3806	2279	7	,	,	PUNCT
fnp-3806	2279	8	hansen	hansen	PROPN
fnp-3806	2279	9	l	l	PROPN
fnp-3806	2279	10	,	,	PUNCT
fnp-3806	2279	11	et	et	PROPN
fnp-3806	2279	12	al	al	PROPN
fnp-3806	2279	13	.	.	PUNCT
fnp-3806	2279	14	patterns	pattern	NOUN
fnp-3806	2279	15	of	of	ADP
fnp-3806	2279	16	aberrant	aberrant	NOUN
fnp-3806	2279	17	sprouting	sprouting	NOUN
fnp-3806	2279	18	in	in	ADP
fnp-3806	2279	19	alzheimer	alzheimer	PROPN
fnp-3806	2279	20	's	's	PART
fnp-3806	2279	21	disease	disease	NOUN
fnp-3806	2279	22	.	.	PUNCT
fnp-3806	2280	1	neuron	neuron	PROPN
fnp-3806	2280	2	1991;6:729	1991;6:729	NUM
fnp-3806	2280	3	-	-	SYM
fnp-3806	2280	4	739	739	NUM
fnp-3806	2280	5	.	.	PUNCT
fnp-3806	2281	1	https://doi.org/10.1016/0896-6273(91)90170-5	https://doi.org/10.1016/0896-6273(91)90170-5	ADJ
fnp-3806	2281	2	masliah	masliah	PROPN
fnp-3806	2281	3	e	e	PROPN
fnp-3806	2281	4	,	,	PUNCT
fnp-3806	2281	5	mallory	mallory	PROPN
fnp-3806	2281	6	m	m	PROPN
fnp-3806	2281	7	,	,	PUNCT
fnp-3806	2281	8	hansen	hansen	PROPN
fnp-3806	2281	9	l	l	PROPN
fnp-3806	2281	10	,	,	PUNCT
fnp-3806	2281	11	et	et	PROPN
fnp-3806	2281	12	al	al	PROPN
fnp-3806	2281	13	.	.	PUNCT
fnp-3806	2282	1	localization	localization	NOUN
fnp-3806	2282	2	of	of	ADP
fnp-3806	2282	3	amyloid	amyloid	NOUN
fnp-3806	2282	4	precursor	precursor	NOUN
fnp-3806	2282	5	protein	protein	NOUN
fnp-3806	2282	6	in	in	ADP
fnp-3806	2282	7	gap43	gap43	NOUN
fnp-3806	2282	8	-	-	PUNCT
fnp-3806	2282	9	immunoreactive	immunoreactive	ADJ
fnp-3806	2282	10	aberrant	aberrant	NOUN
fnp-3806	2282	11	sprouting	sprout	VERB
fnp-3806	2282	12	neurites	neurite	NOUN
fnp-3806	2282	13	in	in	ADP
fnp-3806	2282	14	alzheimer	alzheimer	PROPN
fnp-3806	2282	15	's	's	PART
fnp-3806	2282	16	disease	disease	NOUN
fnp-3806	2282	17	.	.	PUNCT
fnp-3806	2283	1	brain	brain	NOUN
fnp-3806	2283	2	res	re	NOUN
fnp-3806	2283	3	1992;574:312	1992;574:312	NUM
fnp-3806	2283	4	-	-	SYM
fnp-3806	2283	5	316	316	NUM
fnp-3806	2283	6	.	.	PUNCT
fnp-3806	2284	1	https://doi.org/10.1016/0006-8993(92)90831-s	https://doi.org/10.1016/0006-8993(92)90831-s	PROPN
fnp-3806	2284	2	hashimoto	hashimoto	NOUN
fnp-3806	2284	3	m	m	PROPN
fnp-3806	2284	4	,	,	PUNCT
fnp-3806	2284	5	masliah	masliah	PROPN
fnp-3806	2284	6	e.	e.	PROPN
fnp-3806	2284	7	cycles	cycle	NOUN
fnp-3806	2284	8	of	of	ADP
fnp-3806	2284	9	aberrant	aberrant	ADJ
fnp-3806	2284	10	synaptic	synaptic	ADJ
fnp-3806	2284	11	sprouting	sprouting	NOUN
fnp-3806	2284	12	and	and	CCONJ
fnp-3806	2284	13	neurodegeneration	neurodegeneration	NOUN
fnp-3806	2284	14	in	in	ADP
fnp-3806	2284	15	alzheimer	alzheimer	PROPN
fnp-3806	2284	16	's	's	PART
fnp-3806	2284	17	and	and	CCONJ
fnp-3806	2284	18	dementia	dementia	NOUN
fnp-3806	2284	19	with	with	ADP
fnp-3806	2284	20	lewy	lewy	PROPN
fnp-3806	2284	21	bodies	body	NOUN
fnp-3806	2284	22	.	.	PUNCT
fnp-3806	2285	1	neurochem	neurochem	PROPN
fnp-3806	2285	2	res	re	VERB
fnp-3806	2285	3	2003;28:1743	2003;28:1743	PROPN
fnp-3806	2285	4	-	-	SYM
fnp-3806	2285	5	1756	1756	NUM
fnp-3806	2285	6	.	.	PUNCT
fnp-3806	2286	1	https://doi.org/10.1023/a:1026073324672	https://doi.org/10.1023/a:1026073324672	NOUN
fnp-3806	2286	2	merino	merino	NOUN
fnp-3806	2286	3	-	-	PUNCT
fnp-3806	2286	4	serrais	serrais	NOUN
fnp-3806	2286	5	p	p	NOUN
fnp-3806	2286	6	,	,	PUNCT
fnp-3806	2286	7	benavides	benavide	NOUN
fnp-3806	2286	8	-	-	PUNCT
fnp-3806	2286	9	piccione	piccione	NOUN
fnp-3806	2286	10	r	r	NOUN
fnp-3806	2286	11	,	,	PUNCT
fnp-3806	2286	12	blazquez	blazquez	NOUN
fnp-3806	2286	13	-	-	PUNCT
fnp-3806	2286	14	llorca	llorca	NOUN
fnp-3806	2286	15	l	l	NOUN
fnp-3806	2286	16	,	,	PUNCT
fnp-3806	2286	17	et	et	PROPN
fnp-3806	2286	18	al	al	PROPN
fnp-3806	2286	19	.	.	PUNCT
fnp-3806	2287	1	the	the	DET
fnp-3806	2287	2	influence	influence	NOUN
fnp-3806	2287	3	of	of	ADP
fnp-3806	2287	4	phospho	phospho	NOUN
fnp-3806	2287	5	-	-	PUNCT
fnp-3806	2287	6	tau	tau	NOUN
fnp-3806	2287	7	on	on	ADP
fnp-3806	2287	8	dendritic	dendritic	ADJ
fnp-3806	2287	9	spines	spine	NOUN
fnp-3806	2287	10	of	of	ADP
fnp-3806	2287	11	cortical	cortical	ADJ
fnp-3806	2287	12	pyramidal	pyramidal	ADJ
fnp-3806	2287	13	neurons	neuron	NOUN
fnp-3806	2287	14	in	in	ADP
fnp-3806	2287	15	patients	patient	NOUN
fnp-3806	2287	16	with	with	ADP
fnp-3806	2287	17	alzheimer	alzheimer	PROPN
fnp-3806	2287	18	's	's	PART
fnp-3806	2287	19	disease	disease	NOUN
fnp-3806	2287	20	.	.	PUNCT
fnp-3806	2288	1	brain	brain	NOUN
fnp-3806	2288	2	2013;136:1913	2013;136:1913	NUM
fnp-3806	2288	3	-	-	SYM
fnp-3806	2288	4	1928	1928	NUM
fnp-3806	2288	5	.	.	PUNCT
fnp-3806	2289	1	https://doi.org/10.1093/brain/awt088	https://doi.org/10.1093/brain/awt088	NUM
fnp-3806	2289	2	mijalkov	mijalkov	PROPN
fnp-3806	2289	3	m	m	PROPN
fnp-3806	2289	4	,	,	PUNCT
fnp-3806	2289	5	volpe	volpe	PROPN
fnp-3806	2289	6	g	g	PROPN
fnp-3806	2289	7	,	,	PUNCT
fnp-3806	2289	8	fernaud	fernaud	PROPN
fnp-3806	2289	9	-	-	PUNCT
fnp-3806	2289	10	espinosa	espinosa	NOUN
fnp-3806	2289	11	i	i	PRON
fnp-3806	2289	12	,	,	PUNCT
fnp-3806	2289	13	et	et	PROPN
fnp-3806	2289	14	al	al	PROPN
fnp-3806	2289	15	.	.	PUNCT
fnp-3806	2290	1	dendritic	dendritic	ADJ
fnp-3806	2290	2	spines	spine	NOUN
fnp-3806	2290	3	are	be	AUX
fnp-3806	2290	4	lost	lose	VERB
fnp-3806	2290	5	in	in	ADP
fnp-3806	2290	6	clusters	cluster	NOUN
fnp-3806	2290	7	in	in	ADP
fnp-3806	2290	8	alzheimer	alzheimer	PROPN
fnp-3806	2290	9	's	's	PART
fnp-3806	2290	10	disease	disease	NOUN
fnp-3806	2290	11	.	.	PUNCT
fnp-3806	2291	1	sci	sci	PROPN
fnp-3806	2291	2	rep	rep	PROPN
fnp-3806	2291	3	2021;11:12350	2021;11:12350	PROPN
fnp-3806	2291	4	.	.	PUNCT
fnp-3806	2292	1	https://doi.org/10.1038/s41598-021-91726-x	https://doi.org/10.1038/s41598-021-91726-x	VERB
fnp-3806	2292	2	tsai	tsai	PROPN
fnp-3806	2292	3	j	j	PROPN
fnp-3806	2292	4	,	,	PUNCT
fnp-3806	2292	5	grutzendler	grutzendler	PROPN
fnp-3806	2292	6	j	j	PROPN
fnp-3806	2292	7	,	,	PUNCT
fnp-3806	2292	8	duff	duff	PROPN
fnp-3806	2292	9	k	k	PROPN
fnp-3806	2292	10	,	,	PUNCT
fnp-3806	2292	11	et	et	PROPN
fnp-3806	2292	12	al	al	PROPN
fnp-3806	2292	13	.	.	PROPN
fnp-3806	2292	14	fibrillar	fibrillar	PROPN
fnp-3806	2292	15	amyloid	amyloid	NOUN
fnp-3806	2292	16	deposition	deposition	NOUN
fnp-3806	2292	17	leads	lead	VERB
fnp-3806	2292	18	to	to	ADP
fnp-3806	2292	19	local	local	ADJ
fnp-3806	2292	20	synaptic	synaptic	ADJ
fnp-3806	2292	21	abnormalities	abnormality	NOUN
fnp-3806	2292	22	and	and	CCONJ
fnp-3806	2292	23	breakage	breakage	NOUN
fnp-3806	2292	24	of	of	ADP
fnp-3806	2292	25	neuronal	neuronal	ADJ
fnp-3806	2292	26	branches	branch	NOUN
fnp-3806	2292	27	.	.	PUNCT
fnp-3806	2293	1	nat	nat	PROPN
fnp-3806	2293	2	neurosci	neurosci	PROPN
fnp-3806	2293	3	2004;7:1181	2004;7:1181	NUM
fnp-3806	2293	4	-	-	SYM
fnp-3806	2293	5	1183	1183	NUM
fnp-3806	2293	6	.	.	PUNCT
fnp-3806	2294	1	https://doi.org/10.1038/nn1335	https://doi.org/10.1038/nn1335	X
fnp-3806	2294	2	garcia	garcia	PROPN
fnp-3806	2294	3	-	-	PUNCT
fnp-3806	2294	4	marin	marin	PROPN
fnp-3806	2294	5	v	v	NOUN
fnp-3806	2294	6	,	,	PUNCT
fnp-3806	2294	7	blazquez	blazquez	NOUN
fnp-3806	2294	8	-	-	PUNCT
fnp-3806	2294	9	llorca	llorca	NOUN
fnp-3806	2294	10	l	l	NOUN
fnp-3806	2294	11	,	,	PUNCT
fnp-3806	2294	12	rodriguez	rodriguez	PROPN
fnp-3806	2294	13	jr	jr	PROPN
fnp-3806	2294	14	,	,	PUNCT
fnp-3806	2294	15	et	et	PROPN
fnp-3806	2294	16	al	al	PROPN
fnp-3806	2294	17	.	.	PROPN
fnp-3806	2295	1	diminished	diminish	VERB
fnp-3806	2295	2	perisomatic	perisomatic	ADJ
fnp-3806	2295	3	gabaergic	gabaergic	ADJ
fnp-3806	2295	4	terminals	terminal	NOUN
fnp-3806	2295	5	on	on	ADP
fnp-3806	2295	6	cortical	cortical	ADJ
fnp-3806	2295	7	neurons	neuron	NOUN
fnp-3806	2295	8	adjacent	adjacent	ADJ
fnp-3806	2295	9	to	to	PART
fnp-3806	2295	10	amyloid	amyloid	VERB
fnp-3806	2295	11	plaques	plaque	NOUN
fnp-3806	2295	12	.	.	PUNCT
fnp-3806	2296	1	front	front	ADJ
fnp-3806	2296	2	neuroanat	neuroanat	PROPN
fnp-3806	2296	3	2009;3:28	2009;3:28	NOUN
fnp-3806	2296	4	.	.	PUNCT
fnp-3806	2297	1	https://doi.org/10.3389/neuro.05.028.2009	https://doi.org/10.3389/neuro.05.028.2009	PROPN
fnp-3806	2297	2	hoover	hoover	PROPN
fnp-3806	2297	3	br	br	PROPN
fnp-3806	2297	4	,	,	PUNCT
fnp-3806	2297	5	reed	reed	PROPN
fnp-3806	2297	6	mn	mn	PROPN
fnp-3806	2297	7	,	,	PUNCT
fnp-3806	2297	8	su	su	PROPN
fnp-3806	2297	9	s	s	PROPN
fnp-3806	2297	10	,	,	PUNCT
fnp-3806	2297	11	et	et	PROPN
fnp-3806	2297	12	al	al	PROPN
fnp-3806	2297	13	.	.	PUNCT
fnp-3806	2298	1	tau	tau	PROPN
fnp-3806	2298	2	mislocalization	mislocalization	NOUN
fnp-3806	2298	3	to	to	ADP
fnp-3806	2298	4	dendritic	dendritic	ADJ
fnp-3806	2298	5	spines	spine	NOUN
fnp-3806	2298	6	mediates	mediate	VERB
fnp-3806	2298	7	synaptic	synaptic	ADJ
fnp-3806	2298	8	dysfunction	dysfunction	NOUN
fnp-3806	2298	9	independently	independently	ADV
fnp-3806	2298	10	of	of	ADP
fnp-3806	2298	11	neurodegeneration	neurodegeneration	NOUN
fnp-3806	2298	12	.	.	PUNCT
fnp-3806	2299	1	neuron	neuron	PROPN
fnp-3806	2299	2	2010;68:1067	2010;68:1067	PROPN
fnp-3806	2299	3	-	-	SYM
fnp-3806	2299	4	1081	1081	NUM
fnp-3806	2299	5	.	.	PUNCT
fnp-3806	2300	1	https://doi.org/10.1016/j.neuron.2010.11.030	https://doi.org/10.1016/j.neuron.2010.11.030	NUM
fnp-3806	2300	2	yin	yin	PROPN
fnp-3806	2300	3	x	x	X
fnp-3806	2300	4	,	,	PUNCT
fnp-3806	2300	5	zhao	zhao	PROPN
fnp-3806	2300	6	c	c	PROPN
fnp-3806	2300	7	,	,	PUNCT
fnp-3806	2300	8	qiu	qiu	PROPN
fnp-3806	2300	9	y	y	PROPN
fnp-3806	2300	10	,	,	PUNCT
fnp-3806	2300	11	et	et	PROPN
fnp-3806	2300	12	al	al	PROPN
fnp-3806	2300	13	.	.	PUNCT
fnp-3806	2300	14	dendritic	dendritic	ADJ
fnp-3806	2300	15	/	/	SYM
fnp-3806	2300	16	post	post	ADJ
fnp-3806	2300	17	-	-	ADJ
fnp-3806	2300	18	synaptic	synaptic	ADJ
fnp-3806	2300	19	tau	tau	NOUN
fnp-3806	2300	20	and	and	CCONJ
fnp-3806	2300	21	early	early	ADJ
fnp-3806	2300	22	pathology	pathology	NOUN
fnp-3806	2300	23	of	of	ADP
fnp-3806	2300	24	alzheimer	alzheimer	PROPN
fnp-3806	2300	25	's	's	PART
fnp-3806	2300	26	disease	disease	NOUN
fnp-3806	2300	27	.	.	PUNCT
fnp-3806	2301	1	front	front	NOUN
fnp-3806	2301	2	mol	mol	ADP
fnp-3806	2301	3	neurosci	neurosci	PROPN
fnp-3806	2301	4	2021;14:671779	2021;14:671779	PROPN
fnp-3806	2301	5	.	.	PUNCT
fnp-3806	2302	1	https://doi.org/10.3389/fnmol.2021.671779	https://doi.org/10.3389/fnmol.2021.671779	PROPN
fnp-3806	2302	2	masliah	masliah	PROPN
fnp-3806	2302	3	e	e	NOUN
fnp-3806	2302	4	,	,	PUNCT
fnp-3806	2302	5	mallory	mallory	PROPN
fnp-3806	2302	6	m	m	PROPN
fnp-3806	2302	7	,	,	PUNCT
fnp-3806	2302	8	hansen	hansen	PROPN
fnp-3806	2302	9	l	l	PROPN
fnp-3806	2302	10	,	,	PUNCT
fnp-3806	2302	11	et	et	PROPN
fnp-3806	2302	12	al	al	PROPN
fnp-3806	2302	13	.	.	PROPN
fnp-3806	2302	14	synaptic	synaptic	ADJ
fnp-3806	2302	15	and	and	CCONJ
fnp-3806	2302	16	neuritic	neuritic	ADJ
fnp-3806	2302	17	alterations	alteration	NOUN
fnp-3806	2302	18	during	during	ADP
fnp-3806	2302	19	the	the	DET
fnp-3806	2302	20	progression	progression	NOUN
fnp-3806	2302	21	of	of	ADP
fnp-3806	2302	22	alzheimer	alzheimer	PROPN
fnp-3806	2302	23	’s	’s	PART
fnp-3806	2302	24	disease	disease	NOUN
fnp-3806	2302	25	.	.	PUNCT
fnp-3806	2303	1	neurosci	neurosci	PROPN
fnp-3806	2303	2	lett	lett	PROPN
fnp-3806	2303	3	1994;174:67	1994;174:67	PROPN
fnp-3806	2303	4	-	-	SYM
fnp-3806	2303	5	72	72	NUM
fnp-3806	2303	6	.	.	PUNCT
fnp-3806	2304	1	https://doi.org/10.1016/0304-3940(94)90121-x	https://doi.org/10.1016/0304-3940(94)90121-x	NOUN
fnp-3806	2304	2	gouras	gouras	PROPN
fnp-3806	2304	3	gk	gk	PROPN
fnp-3806	2304	4	,	,	PUNCT
fnp-3806	2304	5	willén	willén	PROPN
fnp-3806	2304	6	k	k	PROPN
fnp-3806	2304	7	,	,	PUNCT
fnp-3806	2304	8	faideau	faideau	PROPN
fnp-3806	2304	9	m.	m.	NOUN
fnp-3806	2304	10	the	the	DET
fnp-3806	2304	11	inside	inside	ADV
fnp-3806	2304	12	-	-	PUNCT
fnp-3806	2304	13	out	out	ADP
fnp-3806	2304	14	amyloid	amyloid	NOUN
fnp-3806	2304	15	hypothesis	hypothesis	NOUN
fnp-3806	2304	16	and	and	CCONJ
fnp-3806	2304	17	synapse	synapse	VERB
fnp-3806	2304	18	pathology	pathology	NOUN
fnp-3806	2304	19	in	in	ADP
fnp-3806	2304	20	alzheimer	alzheimer	PROPN
fnp-3806	2304	21	's	's	PART
fnp-3806	2304	22	disease	disease	NOUN
fnp-3806	2304	23	.	.	PUNCT
fnp-3806	2305	1	neurodegener	neurodegener	NOUN
fnp-3806	2305	2	dis	dis	PROPN
fnp-3806	2305	3	2014;13:142	2014;13:142	PROPN
fnp-3806	2305	4	-	-	SYM
fnp-3806	2305	5	146	146	NUM
fnp-3806	2305	6	.	.	PUNCT
fnp-3806	2306	1	https://doi.org/10.1159/000354776	https://doi.org/10.1159/000354776	NOUN
fnp-3806	2306	2	muntané	muntané	VERB
fnp-3806	2306	3	g	g	NOUN
fnp-3806	2306	4	,	,	PUNCT
fnp-3806	2306	5	dalfó	dalfó	NOUN
fnp-3806	2306	6	e	e	NOUN
fnp-3806	2306	7	,	,	PUNCT
fnp-3806	2306	8	martinez	martinez	PROPN
fnp-3806	2306	9	a	a	PROPN
fnp-3806	2306	10	,	,	PUNCT
fnp-3806	2306	11	et	et	PROPN
fnp-3806	2306	12	al	al	PROPN
fnp-3806	2306	13	.	.	PROPN
fnp-3806	2306	14	phosphorylation	phosphorylation	NOUN
fnp-3806	2306	15	of	of	ADP
fnp-3806	2306	16	tau	tau	PROPN
fnp-3806	2306	17	and	and	CCONJ
fnp-3806	2306	18	alpha	alpha	NOUN
fnp-3806	2306	19	-	-	PUNCT
fnp-3806	2306	20	synuclein	synuclein	NOUN
fnp-3806	2306	21	in	in	ADP
fnp-3806	2306	22	synaptic	synaptic	ADJ
fnp-3806	2306	23	-	-	PUNCT
fnp-3806	2306	24	enriched	enrich	VERB
fnp-3806	2306	25	fractions	fraction	NOUN
fnp-3806	2306	26	of	of	ADP
fnp-3806	2306	27	the	the	DET
fnp-3806	2306	28	frontal	frontal	ADJ
fnp-3806	2306	29	cortex	cortex	NOUN
fnp-3806	2306	30	in	in	ADP
fnp-3806	2306	31	alzheimer	alzheimer	PROPN
fnp-3806	2306	32	's	's	PART
fnp-3806	2306	33	disease	disease	NOUN
fnp-3806	2306	34	,	,	PUNCT
fnp-3806	2306	35	and	and	CCONJ
fnp-3806	2306	36	in	in	ADP
fnp-3806	2306	37	parkinson	parkinson	NOUN
fnp-3806	2306	38	's	's	PART
fnp-3806	2306	39	disease	disease	NOUN
fnp-3806	2306	40	and	and	CCONJ
fnp-3806	2306	41	related	relate	VERB
fnp-3806	2306	42	alpha	alpha	NOUN
fnp-3806	2306	43	-	-	PUNCT
fnp-3806	2306	44	synucleinopathies	synucleinopathie	NOUN
fnp-3806	2306	45	.	.	PUNCT
fnp-3806	2307	1	neuroscience	neuroscience	NOUN
fnp-3806	2307	2	2008;152:913	2008;152:913	NUM
fnp-3806	2307	3	-	-	SYM
fnp-3806	2307	4	923	923	NUM
fnp-3806	2307	5	.	.	PUNCT
fnp-3806	2308	1	https://doi.org/10.1016/j.neuroscience.2008.01.030	https://doi.org/10.1016/j.neuroscience.2008.01.030	NUM
fnp-3806	2308	2	gouras	gouras	PROPN
fnp-3806	2308	3	gk	gk	PROPN
fnp-3806	2308	4	,	,	PUNCT
fnp-3806	2308	5	tampellini	tampellini	PROPN
fnp-3806	2308	6	d	d	PROPN
fnp-3806	2308	7	,	,	PUNCT
fnp-3806	2308	8	takahashi	takahashi	PROPN
fnp-3806	2308	9	rh	rh	PROPN
fnp-3806	2308	10	,	,	PUNCT
fnp-3806	2308	11	et	et	PROPN
fnp-3806	2308	12	al	al	PROPN
fnp-3806	2308	13	.	.	PROPN
fnp-3806	2309	1	intraneuronal	intraneuronal	ADJ
fnp-3806	2309	2	beta	beta	NOUN
fnp-3806	2309	3	-	-	PUNCT
fnp-3806	2309	4	amyloid	amyloid	NOUN
fnp-3806	2309	5	accumulation	accumulation	NOUN
fnp-3806	2309	6	and	and	CCONJ
fnp-3806	2309	7	synapse	synapse	VERB
fnp-3806	2309	8	pathology	pathology	NOUN
fnp-3806	2309	9	in	in	ADP
fnp-3806	2309	10	alzheimer	alzheimer	PROPN
fnp-3806	2309	11	's	's	PART
fnp-3806	2309	12	disease	disease	NOUN
fnp-3806	2309	13	.	.	PUNCT
fnp-3806	2310	1	acta	acta	PROPN
fnp-3806	2310	2	neuropathol	neuropathol	PROPN
fnp-3806	2310	3	2010;119:523	2010;119:523	PROPN
fnp-3806	2310	4	-	-	SYM
fnp-3806	2310	5	541	541	NUM
fnp-3806	2310	6	.	.	PUNCT
fnp-3806	2311	1	https://doi.org/10.1007/s00401-010-0679-9	https://doi.org/10.1007/s00401-010-0679-9	NUM
fnp-3806	2311	2	palop	palop	PROPN
fnp-3806	2311	3	jj	jj	PROPN
fnp-3806	2311	4	,	,	PUNCT
fnp-3806	2311	5	mucke	mucke	PROPN
fnp-3806	2311	6	l.	l.	PROPN
fnp-3806	2311	7	amyloid	amyloid	PROPN
fnp-3806	2311	8	-	-	PUNCT
fnp-3806	2311	9	beta	beta	NOUN
fnp-3806	2311	10	-	-	PUNCT
fnp-3806	2311	11	induced	induce	VERB
fnp-3806	2311	12	neuronal	neuronal	ADJ
fnp-3806	2311	13	dysfunction	dysfunction	NOUN
fnp-3806	2311	14	in	in	ADP
fnp-3806	2311	15	alzheimer	alzheimer	PROPN
fnp-3806	2311	16	's	's	PART
fnp-3806	2311	17	disease	disease	NOUN
fnp-3806	2311	18	:	:	PUNCT
fnp-3806	2311	19	from	from	ADP
fnp-3806	2311	20	synapses	synapsis	NOUN
fnp-3806	2311	21	toward	toward	ADP
fnp-3806	2311	22	neural	neural	ADJ
fnp-3806	2311	23	networks	network	NOUN
fnp-3806	2311	24	.	.	PUNCT
fnp-3806	2312	1	nat	nat	PROPN
fnp-3806	2312	2	neurosci	neurosci	PROPN
fnp-3806	2312	3	2010;13:812	2010;13:812	PROPN
fnp-3806	2312	4	-	-	PUNCT
fnp-3806	2312	5	818	818	NUM
fnp-3806	2312	6	.	.	PUNCT
fnp-3806	2313	1	https://doi.org/10.1038/nn.2583	https://doi.org/10.1038/nn.2583	PROPN
fnp-3806	2313	2	sheng	sheng	PROPN
fnp-3806	2313	3	m	m	PROPN
fnp-3806	2313	4	,	,	PUNCT
fnp-3806	2313	5	sabatini	sabatini	PROPN
fnp-3806	2313	6	bl	bl	PROPN
fnp-3806	2313	7	,	,	PUNCT
fnp-3806	2313	8	südhof	südhof	VERB
fnp-3806	2313	9	tc	tc	NUM
fnp-3806	2313	10	.	.	PUNCT
fnp-3806	2313	11	synapses	synapsis	NOUN
fnp-3806	2313	12	and	and	CCONJ
fnp-3806	2313	13	alzheimer	alzheimer	PROPN
fnp-3806	2313	14	's	's	PART
fnp-3806	2313	15	disease	disease	NOUN
fnp-3806	2313	16	.	.	PUNCT
fnp-3806	2314	1	cold	cold	ADJ
fnp-3806	2314	2	spring	spring	NOUN
fnp-3806	2314	3	harb	harb	PROPN
fnp-3806	2314	4	perspect	perspect	VERB
fnp-3806	2314	5	biol	biol	PROPN
fnp-3806	2314	6	2012;4	2012;4	NOUN
fnp-3806	2314	7	:	:	PUNCT
fnp-3806	2314	8	a005777	a005777	ADJ
fnp-3806	2314	9	.	.	PUNCT
fnp-3806	2315	1	capetillo	capetillo	PROPN
fnp-3806	2315	2	-	-	PUNCT
fnp-3806	2315	3	zarate	zarate	PROPN
fnp-3806	2315	4	e	e	PROPN
fnp-3806	2315	5	,	,	PUNCT
fnp-3806	2315	6	gracia	gracia	PROPN
fnp-3806	2315	7	l	l	PROPN
fnp-3806	2315	8	,	,	PUNCT
fnp-3806	2315	9	tampellini	tampellini	PROPN
fnp-3806	2315	10	d	d	PROPN
fnp-3806	2315	11	,	,	PUNCT
fnp-3806	2315	12	et	et	PROPN
fnp-3806	2315	13	al	al	PROPN
fnp-3806	2315	14	.	.	PROPN
fnp-3806	2315	15	intraneuronal	intraneuronal	PROPN
fnp-3806	2316	1	aβ	aβ	NOUN
fnp-3806	2316	2	accumulation	accumulation	NOUN
fnp-3806	2316	3	,	,	PUNCT
fnp-3806	2316	4	amyloid	amyloid	NOUN
fnp-3806	2316	5	plaques	plaque	NOUN
fnp-3806	2316	6	,	,	PUNCT
fnp-3806	2316	7	and	and	CCONJ
fnp-3806	2316	8	synapse	synapse	VERB
fnp-3806	2316	9	pathology	pathology	NOUN
fnp-3806	2316	10	in	in	ADP
fnp-3806	2316	11	alzheimer	alzheimer	PROPN
fnp-3806	2316	12	's	's	PART
fnp-3806	2316	13	disease	disease	NOUN
fnp-3806	2316	14	.	.	PUNCT
fnp-3806	2317	1	neurodegener	neurodegener	PROPN
fnp-3806	2317	2	dis	dis	PROPN
fnp-3806	2317	3	2012;10:56	2012;10:56	NUM
fnp-3806	2317	4	-	-	SYM
fnp-3806	2317	5	59	59	NUM
fnp-3806	2317	6	.	.	PUNCT
fnp-3806	2318	1	https://doi.org/10.1101/cshperspect.a005777	https://doi.org/10.1101/cshperspect.a005777	VERB
fnp-3806	2318	2	spires	spires	PROPN
fnp-3806	2318	3	-	-	PUNCT
fnp-3806	2318	4	jones	jones	PROPN
fnp-3806	2318	5	tl	tl	PROPN
fnp-3806	2318	6	,	,	PUNCT
fnp-3806	2318	7	hyman	hyman	PROPN
fnp-3806	2318	8	bt	bt	PROPN
fnp-3806	2318	9	.	.	PUNCT
fnp-3806	2319	1	the	the	DET
fnp-3806	2319	2	intersection	intersection	NOUN
fnp-3806	2319	3	of	of	ADP
fnp-3806	2319	4	amyloid	amyloid	NOUN
fnp-3806	2319	5	beta	beta	NOUN
fnp-3806	2319	6	and	and	CCONJ
fnp-3806	2319	7	tau	tau	PROPN
fnp-3806	2319	8	at	at	ADP
fnp-3806	2319	9	synapses	synapsis	NOUN
fnp-3806	2319	10	in	in	ADP
fnp-3806	2319	11	alzheimer	alzheimer	PROPN
fnp-3806	2319	12	's	's	PART
fnp-3806	2319	13	disease	disease	NOUN
fnp-3806	2319	14	.	.	PUNCT
fnp-3806	2320	1	neuron	neuron	PROPN
fnp-3806	2320	2	2014;82:756	2014;82:756	PROPN
fnp-3806	2320	3	-	-	NOUN
fnp-3806	2320	4	771	771	NUM
fnp-3806	2320	5	.	.	PUNCT
fnp-3806	2321	1	https://doi.org/10.1016/j.neuron.2014.05.004	https://doi.org/10.1016/j.neuron.2014.05.004	NOUN
fnp-3806	2321	2	rajmohan	rajmohan	ADP
fnp-3806	2321	3	r	r	NOUN
fnp-3806	2321	4	,	,	PUNCT
fnp-3806	2321	5	reddy	reddy	PROPN
fnp-3806	2321	6	ph	ph	PROPN
fnp-3806	2321	7	.	.	PUNCT
fnp-3806	2321	8	amyloid	amyloid	NOUN
fnp-3806	2321	9	-	-	PUNCT
fnp-3806	2321	10	beta	beta	NOUN
fnp-3806	2321	11	and	and	CCONJ
fnp-3806	2321	12	phosphorylated	phosphorylate	VERB
fnp-3806	2321	13	tau	tau	PROPN
fnp-3806	2321	14	accumulations	accumulation	NOUN
fnp-3806	2321	15	cause	cause	VERB
fnp-3806	2321	16	abnormalities	abnormality	NOUN
fnp-3806	2321	17	at	at	ADP
fnp-3806	2321	18	synapses	synapsis	NOUN
fnp-3806	2321	19	of	of	ADP
fnp-3806	2321	20	alzheimer	alzheimer	PROPN
fnp-3806	2321	21	's	's	PART
fnp-3806	2321	22	disease	disease	NOUN
fnp-3806	2321	23	neurons	neuron	NOUN
fnp-3806	2321	24	.	.	PUNCT
fnp-3806	2322	1	j	j	PROPN
fnp-3806	2322	2	alzheimers	alzheimers	PROPN
fnp-3806	2322	3	dis	dis	PROPN
fnp-3806	2322	4	2017;57	2017;57	NUM
fnp-3806	2322	5	:	:	PUNCT
fnp-3806	2322	6	975	975	NUM
fnp-3806	2322	7	-	-	SYM
fnp-3806	2322	8	999	999	NUM
fnp-3806	2322	9	.	.	PUNCT
fnp-3806	2323	1	https://doi.org/10.3233/jad-160612	https://doi.org/10.3233/jad-160612	PROPN
fnp-3806	2323	2	li	li	PROPN
fnp-3806	2323	3	k	k	PROPN
fnp-3806	2323	4	,	,	PUNCT
fnp-3806	2323	5	wei	wei	PROPN
fnp-3806	2323	6	q	q	PROPN
fnp-3806	2323	7	,	,	PUNCT
fnp-3806	2323	8	liu	liu	PROPN
fnp-3806	2323	9	ff	ff	PROPN
fnp-3806	2323	10	,	,	PUNCT
fnp-3806	2323	11	et	et	PROPN
fnp-3806	2323	12	al	al	PROPN
fnp-3806	2323	13	.	.	PUNCT
fnp-3806	2324	1	synaptic	synaptic	ADJ
fnp-3806	2324	2	dysfunction	dysfunction	NOUN
fnp-3806	2324	3	in	in	ADP
fnp-3806	2324	4	alzheimer	alzheimer	PROPN
fnp-3806	2324	5	's	's	PART
fnp-3806	2324	6	disease	disease	NOUN
fnp-3806	2324	7	:	:	PUNCT
fnp-3806	2324	8	abeta	abeta	PROPN
fnp-3806	2324	9	,	,	PUNCT
fnp-3806	2324	10	tau	tau	PROPN
fnp-3806	2324	11	,	,	PUNCT
fnp-3806	2324	12	and	and	CCONJ
fnp-3806	2324	13	epigenetic	epigenetic	ADJ
fnp-3806	2324	14	alterations	alteration	NOUN
fnp-3806	2324	15	.	.	PUNCT
fnp-3806	2325	1	mol	mol	ADP
fnp-3806	2325	2	neurobiol	neurobiol	PROPN
fnp-3806	2325	3	2018;55:3021	2018;55:3021	NUM
fnp-3806	2325	4	-	-	SYM
fnp-3806	2325	5	3032	3032	NUM
fnp-3806	2325	6	.	.	PUNCT
fnp-3806	2326	1	https://doi.org/10.1007/s12035-017-0533-3	https://doi.org/10.1007/s12035-017-0533-3	NUM
fnp-3806	2326	2	chen	chen	PROPN
fnp-3806	2326	3	y	y	PROPN
fnp-3806	2326	4	,	,	PUNCT
fnp-3806	2326	5	fu	fu	PROPN
fnp-3806	2326	6	aky	aky	PROPN
fnp-3806	2326	7	,	,	PUNCT
fnp-3806	2326	8	ip	ip	PROPN
fnp-3806	2326	9	ny	ny	PROPN
fnp-3806	2326	10	.	.	PROPN
fnp-3806	2326	11	synaptic	synaptic	ADJ
fnp-3806	2326	12	dysfunction	dysfunction	NOUN
fnp-3806	2326	13	in	in	ADP
fnp-3806	2326	14	alzheimer	alzheimer	PROPN
fnp-3806	2326	15	’s	’s	PART
fnp-3806	2326	16	disease	disease	NOUN
fnp-3806	2326	17	:	:	PUNCT
fnp-3806	2326	18	mechanisms	mechanism	NOUN
fnp-3806	2326	19	and	and	CCONJ
fnp-3806	2326	20	therapeutic	therapeutic	ADJ
fnp-3806	2326	21	strategies	strategy	NOUN
fnp-3806	2326	22	.	.	PUNCT
fnp-3806	2327	1	pharmacol	pharmacol	NOUN
fnp-3806	2327	2	ther	ther	ADV
fnp-3806	2327	3	2019;195:186	2019;195:186	PROPN
fnp-3806	2327	4	-	-	SYM
fnp-3806	2327	5	198	198	NUM
fnp-3806	2327	6	.	.	PUNCT
fnp-3806	2328	1	https://doi.org/10.1016/j.pharmthera.2018.11.006	https://doi.org/10.1016/j.pharmthera.2018.11.006	PROPN
fnp-3806	2328	2	john	john	PROPN
fnp-3806	2328	3	a	a	PROPN
fnp-3806	2328	4	,	,	PUNCT
fnp-3806	2328	5	reddy	reddy	PROPN
fnp-3806	2328	6	ph	ph	VERB
fnp-3806	2328	7	.	.	PROPN
fnp-3806	2328	8	synaptic	synaptic	ADJ
fnp-3806	2328	9	basis	basis	NOUN
fnp-3806	2328	10	of	of	ADP
fnp-3806	2328	11	alzheimer	alzheimer	PROPN
fnp-3806	2328	12	's	's	PART
fnp-3806	2328	13	disease	disease	NOUN
fnp-3806	2328	14	:	:	PUNCT
fnp-3806	2328	15	focus	focus	VERB
fnp-3806	2328	16	on	on	ADP
fnp-3806	2328	17	synaptic	synaptic	ADJ
fnp-3806	2328	18	amyloid	amyloid	NOUN
fnp-3806	2328	19	beta	beta	NOUN
fnp-3806	2328	20	,	,	PUNCT
fnp-3806	2328	21	p	p	PROPN
fnp-3806	2328	22	-	-	PUNCT
fnp-3806	2328	23	tau	tau	PROPN
fnp-3806	2328	24	and	and	CCONJ
fnp-3806	2328	25	mitochondria	mitochondria	NOUN
fnp-3806	2328	26	.	.	PUNCT
fnp-3806	2329	1	ageing	age	VERB
fnp-3806	2329	2	res	re	NOUN
fnp-3806	2329	3	rev	rev	VERB
fnp-3806	2329	4	2021;65:101208	2021;65:101208	NUM
fnp-3806	2329	5	.	.	PUNCT
fnp-3806	2330	1	https://doi.org/10.1016/j.arr.2020.101208	https://doi.org/10.1016/j.arr.2020.101208	PROPN
fnp-3806	2330	2	coomans	cooman	VERB
fnp-3806	2330	3	em	em	PRON
fnp-3806	2330	4	,	,	PUNCT
fnp-3806	2330	5	schoonhoven	schoonhoven	ADJ
fnp-3806	2330	6	dn	dn	ADP
fnp-3806	2330	7	,	,	PUNCT
fnp-3806	2330	8	tuncel	tuncel	VERB
fnp-3806	2330	9	h	h	NOUN
fnp-3806	2330	10	,	,	PUNCT
fnp-3806	2330	11	et	et	PROPN
fnp-3806	2330	12	al	al	PROPN
fnp-3806	2330	13	.	.	PROPN
fnp-3806	2331	1	in	in	ADP
fnp-3806	2331	2	vivo	vivo	NOUN
fnp-3806	2331	3	tau	tau	PROPN
fnp-3806	2331	4	pathology	pathology	NOUN
fnp-3806	2331	5	is	be	AUX
fnp-3806	2331	6	associated	associate	VERB
fnp-3806	2331	7	with	with	ADP
fnp-3806	2331	8	synaptic	synaptic	ADJ
fnp-3806	2331	9	loss	loss	NOUN
fnp-3806	2331	10	and	and	CCONJ
fnp-3806	2331	11	altered	alter	VERB
fnp-3806	2331	12	synaptic	synaptic	ADJ
fnp-3806	2331	13	function	function	NOUN
fnp-3806	2331	14	.	.	PUNCT
fnp-3806	2332	1	alzheimers	alzheimer	NOUN
fnp-3806	2332	2	res	re	VERB
fnp-3806	2332	3	ther	ther	PROPN
fnp-3806	2332	4	2021;13:35	2021;13:35	NUM
fnp-3806	2332	5	.	.	PUNCT
fnp-3806	2333	1	https://doi.org/10.1186/s13195-021-00772-0	https://doi.org/10.1186/s13195-021-00772-0	NUM
fnp-3806	2333	2	de	de	X
fnp-3806	2333	3	vos	vos	PROPN
fnp-3806	2333	4	sl	sl	PROPN
fnp-3806	2333	5	,	,	PUNCT
fnp-3806	2333	6	corjuc	corjuc	VERB
fnp-3806	2333	7	bt	bt	ADJ
fnp-3806	2333	8	,	,	PUNCT
fnp-3806	2333	9	oakley	oakley	PROPN
fnp-3806	2333	10	dh	dh	PROPN
fnp-3806	2333	11	,	,	PUNCT
fnp-3806	2333	12	et	et	PROPN
fnp-3806	2333	13	al	al	PROPN
fnp-3806	2333	14	.	.	PROPN
fnp-3806	2334	1	synaptic	synaptic	ADJ
fnp-3806	2334	2	tau	tau	PROPN
fnp-3806	2334	3	seeding	seed	VERB
fnp-3806	2334	4	precedes	precede	VERB
fnp-3806	2334	5	tau	tau	PROPN
fnp-3806	2334	6	pathology	pathology	NOUN
fnp-3806	2334	7	in	in	ADP
fnp-3806	2334	8	human	human	PROPN
fnp-3806	2334	9	alzheimer	alzheimer	PROPN
fnp-3806	2334	10	’s	’s	PART
fnp-3806	2334	11	disease	disease	NOUN
fnp-3806	2334	12	brain	brain	NOUN
fnp-3806	2334	13	.	.	PUNCT
fnp-3806	2335	1	front	front	ADJ
fnp-3806	2335	2	neurosci	neurosci	NOUN
fnp-3806	2335	3	2018;12	2018;12	NUM
fnp-3806	2335	4	:	:	PUNCT
fnp-3806	2335	5	267	267	NUM
fnp-3806	2335	6	.	.	PUNCT
fnp-3806	2336	1	https://doi.org/10.3389/fnins.2018.00267	https://doi.org/10.3389/fnins.2018.00267	PROPN
fnp-3806	2336	2	pelucchi	pelucchi	PROPN
fnp-3806	2336	3	s	s	PROPN
fnp-3806	2336	4	,	,	PUNCT
fnp-3806	2336	5	stringhi	stringhi	PROPN
fnp-3806	2336	6	r	r	PROPN
fnp-3806	2336	7	,	,	PUNCT
fnp-3806	2336	8	marcello	marcello	PROPN
fnp-3806	2336	9	e.	e.	PROPN
fnp-3806	2336	10	dendritic	dendritic	PROPN
fnp-3806	2336	11	spines	spine	NOUN
fnp-3806	2336	12	in	in	ADP
fnp-3806	2336	13	alzheimer	alzheimer	PROPN
fnp-3806	2336	14	's	's	PART
fnp-3806	2336	15	disease	disease	NOUN
fnp-3806	2336	16	:	:	PUNCT
fnp-3806	2336	17	how	how	SCONJ
fnp-3806	2336	18	the	the	DET
fnp-3806	2336	19	actin	actin	NOUN
fnp-3806	2336	20	cytoskeleton	cytoskeleton	PROPN
fnp-3806	2336	21	contributes	contribute	VERB
fnp-3806	2336	22	to	to	ADP
fnp-3806	2336	23	synaptic	synaptic	ADJ
fnp-3806	2336	24	failure	failure	NOUN
fnp-3806	2336	25	.	.	PUNCT
fnp-3806	2337	1	int	int	PROPN
fnp-3806	2337	2	j	j	PROPN
fnp-3806	2337	3	mol	mol	ADP
fnp-3806	2337	4	sci	sci	PROPN
fnp-3806	2337	5	2020;21:908	2020;21:908	PROPN
fnp-3806	2337	6	.	.	PUNCT
fnp-3806	2338	1	https://doi.org/10.3390/ijms21030908	https://doi.org/10.3390/ijms21030908	PROPN
fnp-3806	2338	2	kamat	kamat	PROPN
fnp-3806	2338	3	pk	pk	PROPN
fnp-3806	2338	4	,	,	PUNCT
fnp-3806	2338	5	kalani	kalani	PROPN
fnp-3806	2338	6	a	a	X
fnp-3806	2338	7	,	,	PUNCT
fnp-3806	2338	8	rai	rai	PROPN
fnp-3806	2338	9	s	s	PROPN
fnp-3806	2338	10	,	,	PUNCT
fnp-3806	2338	11	et	et	PROPN
fnp-3806	2338	12	al	al	PROPN
fnp-3806	2338	13	.	.	PUNCT
fnp-3806	2338	14	mechanism	mechanism	NOUN
fnp-3806	2338	15	of	of	ADP
fnp-3806	2338	16	oxidative	oxidative	ADJ
fnp-3806	2338	17	stress	stress	NOUN
fnp-3806	2338	18	and	and	CCONJ
fnp-3806	2338	19	synapse	synapse	VERB
fnp-3806	2338	20	dysfunction	dysfunction	NOUN
fnp-3806	2338	21	in	in	ADP
fnp-3806	2338	22	the	the	DET
fnp-3806	2338	23	pathogenesis	pathogenesis	NOUN
fnp-3806	2338	24	of	of	ADP
fnp-3806	2338	25	alzheimer	alzheimer	PROPN
fnp-3806	2338	26	's	's	PART
fnp-3806	2338	27	disease	disease	NOUN
fnp-3806	2338	28	:	:	PUNCT
fnp-3806	2338	29	understanding	understand	VERB
fnp-3806	2338	30	the	the	DET
fnp-3806	2338	31	therapeutics	therapeutic	NOUN
fnp-3806	2338	32	strategies	strategy	NOUN
fnp-3806	2338	33	.	.	PUNCT
fnp-3806	2339	1	mol	mol	ADP
fnp-3806	2339	2	neurobiol	neurobiol	PROPN
fnp-3806	2339	3	2016;53:648	2016;53:648	NUM
fnp-3806	2339	4	-	-	SYM
fnp-3806	2339	5	661	661	NUM
fnp-3806	2339	6	.	.	PUNCT
fnp-3806	2340	1	https://doi.org/10.1007/s12035-014-9053-6	https://doi.org/10.1007/s12035-014-9053-6	PROPN
fnp-3806	2340	2	arendt	arendt	PROPN
fnp-3806	2340	3	t	t	PROPN
fnp-3806	2340	4	,	,	PUNCT
fnp-3806	2340	5	brückner	brückner	NOUN
fnp-3806	2340	6	mk	mk	PROPN
fnp-3806	2340	7	.	.	PUNCT
fnp-3806	2341	1	linking	link	VERB
fnp-3806	2341	2	cell	cell	NOUN
fnp-3806	2341	3	-	-	PUNCT
fnp-3806	2341	4	cycle	cycle	NOUN
fnp-3806	2341	5	dysfunction	dysfunction	NOUN
fnp-3806	2341	6	in	in	ADP
fnp-3806	2341	7	alzheimer	alzheimer	PROPN
fnp-3806	2341	8	's	's	PART
fnp-3806	2341	9	disease	disease	NOUN
fnp-3806	2341	10	to	to	ADP
fnp-3806	2341	11	a	a	DET
fnp-3806	2341	12	failure	failure	NOUN
fnp-3806	2341	13	of	of	ADP
fnp-3806	2341	14	synaptic	synaptic	ADJ
fnp-3806	2341	15	plasticity	plasticity	NOUN
fnp-3806	2341	16	.	.	PUNCT
fnp-3806	2342	1	biochim	biochim	PROPN
fnp-3806	2342	2	biophys	biophy	NOUN
fnp-3806	2342	3	acta	acta	PROPN
fnp-3806	2342	4	2007;1772:413	2007;1772:413	PROPN
fnp-3806	2342	5	-	-	PUNCT
fnp-3806	2342	6	421	421	NUM
fnp-3806	2342	7	.	.	PUNCT
fnp-3806	2343	1	https://doi.org/10.1016/j.bbadis.2006.12.005	https://doi.org/10.1016/j.bbadis.2006.12.005	VERB
fnp-3806	2343	2	li	li	PROPN
fnp-3806	2343	3	s	s	PROPN
fnp-3806	2343	4	,	,	PUNCT
fnp-3806	2343	5	sheng	sheng	PROPN
fnp-3806	2343	6	zh	zh	PROPN
fnp-3806	2343	7	.	.	PUNCT
fnp-3806	2343	8	energy	energy	NOUN
fnp-3806	2343	9	matters	matter	NOUN
fnp-3806	2343	10	:	:	PUNCT
fnp-3806	2343	11	presynaptic	presynaptic	ADJ
fnp-3806	2343	12	metabolism	metabolism	NOUN
fnp-3806	2343	13	and	and	CCONJ
fnp-3806	2343	14	the	the	DET
fnp-3806	2343	15	maintenance	maintenance	NOUN
fnp-3806	2343	16	of	of	ADP
fnp-3806	2343	17	synaptic	synaptic	ADJ
fnp-3806	2343	18	transmission	transmission	NOUN
fnp-3806	2343	19	.	.	PUNCT
fnp-3806	2344	1	nat	nat	PROPN
fnp-3806	2344	2	rev	rev	VERB
fnp-3806	2344	3	neurosci	neurosci	PROPN
fnp-3806	2344	4	2022;23:4	2022;23:4	PROPN
fnp-3806	2344	5	-	-	PUNCT
fnp-3806	2344	6	22	22	NUM
fnp-3806	2344	7	.	.	PUNCT
fnp-3806	2345	1	https://doi.org/10.1038/s41583-021-00535-8	https://doi.org/10.1038/s41583-021-00535-8	PROPN
fnp-3806	2345	2	davies	davy	NOUN
fnp-3806	2345	3	p	p	X
fnp-3806	2345	4	,	,	PUNCT
fnp-3806	2345	5	maloney	maloney	PROPN
fnp-3806	2345	6	aj	aj	PROPN
fnp-3806	2345	7	.	.	PROPN
fnp-3806	2345	8	selective	selective	ADJ
fnp-3806	2345	9	loss	loss	NOUN
fnp-3806	2345	10	of	of	ADP
fnp-3806	2345	11	central	central	ADJ
fnp-3806	2345	12	cholinergic	cholinergic	ADJ
fnp-3806	2345	13	neurons	neuron	NOUN
fnp-3806	2345	14	in	in	ADP
fnp-3806	2345	15	alzheimer	alzheimer	PROPN
fnp-3806	2345	16	's	's	PART
fnp-3806	2345	17	disease	disease	NOUN
fnp-3806	2345	18	.	.	PUNCT
fnp-3806	2346	1	lancet	lancet	PROPN
fnp-3806	2346	2	1976;2:1403	1976;2:1403	PROPN
fnp-3806	2346	3	.	.	PUNCT
fnp-3806	2347	1	https://doi.org/10.1016/s0140-6736(76)91936-x	https://doi.org/10.1016/s0140-6736(76)91936-x	PROPN
fnp-3806	2347	2	perry	perry	PROPN
fnp-3806	2347	3	ek	ek	PROPN
fnp-3806	2347	4	,	,	PUNCT
fnp-3806	2347	5	tomlinson	tomlinson	PROPN
fnp-3806	2347	6	be	be	PROPN
fnp-3806	2347	7	,	,	PUNCT
fnp-3806	2347	8	blessed	bless	VERB
fnp-3806	2347	9	g	g	PROPN
fnp-3806	2347	10	,	,	PUNCT
fnp-3806	2347	11	et	et	PROPN
fnp-3806	2347	12	al	al	PROPN
fnp-3806	2347	13	.	.	PUNCT
fnp-3806	2348	1	correlation	correlation	NOUN
fnp-3806	2348	2	of	of	ADP
fnp-3806	2348	3	cholinergic	cholinergic	ADJ
fnp-3806	2348	4	abnormalities	abnormality	NOUN
fnp-3806	2348	5	with	with	ADP
fnp-3806	2348	6	senile	senile	ADJ
fnp-3806	2348	7	plaques	plaque	NOUN
fnp-3806	2348	8	and	and	CCONJ
fnp-3806	2348	9	mental	mental	ADJ
fnp-3806	2348	10	test	test	NOUN
fnp-3806	2348	11	scores	score	NOUN
fnp-3806	2348	12	in	in	ADP
fnp-3806	2348	13	senile	senile	ADJ
fnp-3806	2348	14	dementia	dementia	NOUN
fnp-3806	2348	15	.	.	PUNCT
fnp-3806	2349	1	br	br	PROPN
fnp-3806	2349	2	med	med	PROPN
fnp-3806	2349	3	j	j	PROPN
fnp-3806	2349	4	1978;2:1457	1978;2:1457	NUM
fnp-3806	2349	5	-	-	SYM
fnp-3806	2349	6	1459	1459	NUM
fnp-3806	2349	7	.	.	PUNCT
fnp-3806	2350	1	https://doi.org/10.1136/bmj.2.6150.1457	https://doi.org/10.1136/bmj.2.6150.1457	PROPN
fnp-3806	2350	2	coyle	coyle	PROPN
fnp-3806	2350	3	jt	jt	PROPN
fnp-3806	2350	4	,	,	PUNCT
fnp-3806	2350	5	price	price	PROPN
fnp-3806	2350	6	dl	dl	PROPN
fnp-3806	2350	7	,	,	PUNCT
fnp-3806	2350	8	delong	delong	PROPN
fnp-3806	2350	9	mr	mr	PROPN
fnp-3806	2350	10	.	.	PROPN
fnp-3806	2350	11	alzheimer	alzheimer	PROPN
fnp-3806	2350	12	’s	’s	PART
fnp-3806	2350	13	disease	disease	NOUN
fnp-3806	2350	14	:	:	PUNCT
fnp-3806	2350	15	a	a	DET
fnp-3806	2350	16	disorder	disorder	NOUN
fnp-3806	2350	17	of	of	ADP
fnp-3806	2350	18	cortical	cortical	ADJ
fnp-3806	2350	19	cholinergic	cholinergic	ADJ
fnp-3806	2350	20	innervation	innervation	NOUN
fnp-3806	2350	21	.	.	PUNCT
fnp-3806	2351	1	science	science	NOUN
fnp-3806	2351	2	1983;219:1184	1983;219:1184	NUM
fnp-3806	2351	3	-	-	SYM
fnp-3806	2351	4	1190	1190	NUM
fnp-3806	2351	5	.	.	PUNCT
fnp-3806	2352	1	https://doi.org/10.1126/science.6338589	https://doi.org/10.1126/science.6338589	PROPN
fnp-3806	2352	2	francis	francis	PROPN
fnp-3806	2352	3	pt	pt	PROPN
fnp-3806	2352	4	,	,	PUNCT
fnp-3806	2352	5	palmer	palmer	PROPN
fnp-3806	2352	6	am	am	PROPN
fnp-3806	2352	7	,	,	PUNCT
fnp-3806	2352	8	snape	snape	PROPN
fnp-3806	2352	9	m	m	PROPN
fnp-3806	2352	10	,	,	PUNCT
fnp-3806	2352	11	et	et	PROPN
fnp-3806	2352	12	al	al	PROPN
fnp-3806	2352	13	.	.	PUNCT
fnp-3806	2353	1	the	the	DET
fnp-3806	2353	2	cholinergic	cholinergic	ADJ
fnp-3806	2353	3	hypothesis	hypothesis	NOUN
fnp-3806	2353	4	of	of	ADP
fnp-3806	2353	5	alzheimer	alzheimer	PROPN
fnp-3806	2353	6	’s	’s	PART
fnp-3806	2353	7	disease	disease	NOUN
fnp-3806	2353	8	:	:	PUNCT
fnp-3806	2353	9	a	a	DET
fnp-3806	2353	10	review	review	NOUN
fnp-3806	2353	11	of	of	ADP
fnp-3806	2353	12	progress	progress	NOUN
fnp-3806	2353	13	.	.	PUNCT
fnp-3806	2354	1	j	j	PROPN
fnp-3806	2354	2	neurol	neurol	PROPN
fnp-3806	2354	3	neurosurg	neurosurg	PROPN
fnp-3806	2354	4	psychiatry	psychiatry	NOUN
fnp-3806	2354	5	1999;66:137	1999;66:137	NUM
fnp-3806	2354	6	-	-	SYM
fnp-3806	2354	7	147	147	NUM
fnp-3806	2354	8	.	.	PUNCT
fnp-3806	2355	1	https://doi.org/10.1136/jnnp.66.2.137	https://doi.org/10.1136/jnnp.66.2.137	PROPN
fnp-3806	2355	2	lees	lee	NOUN
fnp-3806	2355	3	aj	aj	PROPN
fnp-3806	2355	4	,	,	PUNCT
fnp-3806	2355	5	tolosa	tolosa	PROPN
fnp-3806	2355	6	e	e	NOUN
fnp-3806	2355	7	,	,	PUNCT
fnp-3806	2355	8	olanow	olanow	PROPN
fnp-3806	2355	9	cw	cw	NOUN
fnp-3806	2355	10	.	.	PROPN
fnp-3806	2355	11	four	four	NUM
fnp-3806	2355	12	pioneers	pioneer	NOUN
fnp-3806	2355	13	of	of	ADP
fnp-3806	2355	14	l	l	NOUN
fnp-3806	2355	15	-	-	PUNCT
fnp-3806	2355	16	dopa	dopa	NOUN
fnp-3806	2355	17	treatment	treatment	NOUN
fnp-3806	2355	18	:	:	PUNCT
fnp-3806	2355	19	arvid	arvid	PROPN
fnp-3806	2355	20	carlsson	carlsson	PROPN
fnp-3806	2355	21	,	,	PUNCT
fnp-3806	2355	22	oleh	oleh	PROPN
fnp-3806	2355	23	hornykiewicz	hornykiewicz	PROPN
fnp-3806	2355	24	,	,	PUNCT
fnp-3806	2355	25	george	george	PROPN
fnp-3806	2355	26	cotzias	cotzia	NOUN
fnp-3806	2355	27	,	,	PUNCT
fnp-3806	2355	28	and	and	CCONJ
fnp-3806	2355	29	melvin	melvin	PROPN
fnp-3806	2355	30	yahr	yahr	PROPN
fnp-3806	2355	31	.	.	PUNCT
fnp-3806	2356	1	mov	mov	PROPN
fnp-3806	2356	2	disord	disord	PROPN
fnp-3806	2356	3	2015;30:19	2015;30:19	NUM
fnp-3806	2356	4	-	-	SYM
fnp-3806	2356	5	36	36	NUM
fnp-3806	2356	6	.	.	PUNCT
fnp-3806	2357	1	https://doi.org/10.1002/mds.26120	https://doi.org/10.1002/mds.26120	PROPN
fnp-3806	2357	2	hynd	hynd	PROPN
fnp-3806	2357	3	mr	mr	PROPN
fnp-3806	2357	4	,	,	PUNCT
fnp-3806	2357	5	scott	scott	PROPN
fnp-3806	2357	6	hl	hl	PROPN
fnp-3806	2357	7	,	,	PUNCT
fnp-3806	2357	8	dodd	dodd	PROPN
fnp-3806	2357	9	pr	pr	AUX
fnp-3806	2357	10	.	.	PUNCT
fnp-3806	2358	1	glutamate	glutamate	NOUN
fnp-3806	2358	2	-	-	PUNCT
fnp-3806	2358	3	mediated	mediate	VERB
fnp-3806	2358	4	excitotoxicity	excitotoxicity	NOUN
fnp-3806	2358	5	and	and	CCONJ
fnp-3806	2358	6	neurodegeneration	neurodegeneration	NOUN
fnp-3806	2358	7	in	in	ADP
fnp-3806	2358	8	alzheimer	alzheimer	PROPN
fnp-3806	2358	9	’s	’s	PART
fnp-3806	2358	10	disease	disease	NOUN
fnp-3806	2358	11	.	.	PUNCT
fnp-3806	2359	1	neurochem	neurochem	PROPN
fnp-3806	2359	2	int	int	VERB
fnp-3806	2359	3	2004;45:583	2004;45:583	NUM
fnp-3806	2359	4	-	-	SYM
fnp-3806	2359	5	595	595	NUM
fnp-3806	2359	6	.	.	PUNCT
fnp-3806	2360	1	https://doi.org/10.1016/j.neuint.2004.03.007	https://doi.org/10.1016/j.neuint.2004.03.007	PROPN
fnp-3806	2360	2	parsons	parsons	PROPN
fnp-3806	2360	3	mp	mp	PROPN
fnp-3806	2360	4	,	,	PUNCT
fnp-3806	2360	5	raimond	raimond	VERB
fnp-3806	2360	6	la	la	ADJ
fnp-3806	2360	7	.	.	PUNCT
fnp-3806	2360	8	extrasynaptic	extrasynaptic	ADJ
fnp-3806	2360	9	nmda	nmda	ADJ
fnp-3806	2360	10	receptor	receptor	NOUN
fnp-3806	2360	11	involvement	involvement	NOUN
fnp-3806	2360	12	in	in	ADP
fnp-3806	2360	13	central	central	ADJ
fnp-3806	2360	14	nervous	nervous	ADJ
fnp-3806	2360	15	system	system	NOUN
fnp-3806	2360	16	disorders	disorder	NOUN
fnp-3806	2360	17	.	.	PUNCT
fnp-3806	2361	1	neuron	neuron	PROPN
fnp-3806	2361	2	2014;82	2014;82	NUM
fnp-3806	2361	3	:	:	PUNCT
fnp-3806	2361	4	279	279	NUM
fnp-3806	2361	5	-	-	SYM
fnp-3806	2361	6	293	293	NUM
fnp-3806	2361	7	.	.	PUNCT
fnp-3806	2362	1	https://doi.org/10.1016/j.neuron.2014.03.030	https://doi.org/10.1016/j.neuron.2014.03.030	PROPN
fnp-3806	2362	2	rothstein	rothstein	PROPN
fnp-3806	2362	3	jd	jd	PROPN
fnp-3806	2362	4	,	,	PUNCT
fnp-3806	2362	5	martin	martin	PROPN
fnp-3806	2362	6	lj	lj	PROPN
fnp-3806	2362	7	,	,	PUNCT
fnp-3806	2362	8	kuncl	kuncl	PROPN
fnp-3806	2362	9	rw	rw	PROPN
fnp-3806	2362	10	.	.	PROPN
fnp-3806	2362	11	decreased	decrease	VERB
fnp-3806	2362	12	glutamate	glutamate	ADJ
fnp-3806	2362	13	transport	transport	NOUN
fnp-3806	2362	14	by	by	ADP
fnp-3806	2362	15	the	the	DET
fnp-3806	2362	16	brain	brain	NOUN
fnp-3806	2362	17	and	and	CCONJ
fnp-3806	2362	18	spinal	spinal	ADJ
fnp-3806	2362	19	cord	cord	NOUN
fnp-3806	2362	20	in	in	ADP
fnp-3806	2362	21	amyotrophic	amyotrophic	ADJ
fnp-3806	2362	22	lateral	lateral	ADJ
fnp-3806	2362	23	sclerosis	sclerosis	NOUN
fnp-3806	2362	24	.	.	PUNCT
fnp-3806	2363	1	n	n	PROPN
fnp-3806	2363	2	engl	engl	PROPN
fnp-3806	2363	3	j	j	PROPN
fnp-3806	2363	4	med	med	PROPN
fnp-3806	2363	5	1992;326:1464	1992;326:1464	NUM
fnp-3806	2363	6	-	-	PUNCT
fnp-3806	2363	7	1468	1468	NUM
fnp-3806	2363	8	.	.	PUNCT
fnp-3806	2364	1	https://doi.org/10.1056/nejm199205283262204	https://doi.org/10.1056/nejm199205283262204	PROPN
fnp-3806	2364	2	meldrum	meldrum	PROPN
fnp-3806	2364	3	b	b	PROPN
fnp-3806	2364	4	,	,	PUNCT
fnp-3806	2364	5	garthwaite	garthwaite	ADJ
fnp-3806	2364	6	j.	j.	PROPN
fnp-3806	2364	7	excitatory	excitatory	PROPN
fnp-3806	2364	8	amino	amino	NOUN
fnp-3806	2364	9	acid	acid	NOUN
fnp-3806	2364	10	neurotoxicity	neurotoxicity	NOUN
fnp-3806	2364	11	and	and	CCONJ
fnp-3806	2364	12	neurodegenerative	neurodegenerative	ADJ
fnp-3806	2364	13	disease	disease	NOUN
fnp-3806	2364	14	.	.	PUNCT
fnp-3806	2365	1	trends	trend	NOUN
fnp-3806	2365	2	pharmacol	pharmacol	VERB
fnp-3806	2365	3	sci	sci	PROPN
fnp-3806	2365	4	1990;11:379	1990;11:379	NUM
fnp-3806	2365	5	-	-	SYM
fnp-3806	2365	6	387	387	NUM
fnp-3806	2365	7	.	.	PUNCT
fnp-3806	2366	1	https://doi.org/10.1016/0165-6147(90)90184-a	https://doi.org/10.1016/0165-6147(90)90184-a	PROPN
fnp-3806	2366	2	song	song	PROPN
fnp-3806	2366	3	j	j	PROPN
fnp-3806	2366	4	,	,	PUNCT
fnp-3806	2366	5	yanga	yanga	NOUN
fnp-3806	2366	6	x	x	NOUN
fnp-3806	2366	7	,	,	PUNCT
fnp-3806	2366	8	zhanga	zhanga	PROPN
fnp-3806	2366	9	m	m	PROPN
fnp-3806	2366	10	,	,	PUNCT
fnp-3806	2366	11	et	et	PROPN
fnp-3806	2366	12	al	al	PROPN
fnp-3806	2366	13	.	.	PROPN
fnp-3806	2367	1	glutamate	glutamate	VERB
fnp-3806	2367	2	metabolism	metabolism	NOUN
fnp-3806	2367	3	in	in	ADP
fnp-3806	2367	4	mitochondria	mitochondria	NOUN
fnp-3806	2367	5	is	be	AUX
fnp-3806	2367	6	closely	closely	ADV
fnp-3806	2367	7	related	relate	VERB
fnp-3806	2367	8	to	to	ADP
fnp-3806	2367	9	alzheimer	alzheimer	PROPN
fnp-3806	2367	10	’s	’s	PART
fnp-3806	2367	11	disease	disease	NOUN
fnp-3806	2367	12	.	.	PUNCT
fnp-3806	2368	1	j	j	PROPN
fnp-3806	2368	2	alzheimers	alzheimers	PROPN
fnp-3806	2368	3	dis	dis	PROPN
fnp-3806	2368	4	2021;84:557	2021;84:557	NOUN
fnp-3806	2368	5	-	-	PUNCT
fnp-3806	2368	6	578	578	NUM
fnp-3806	2368	7	.	.	PUNCT
fnp-3806	2369	1	https://doi.org/10.3233/jad-210595	https://doi.org/10.3233/jad-210595	NUM
fnp-3806	2369	2	hardingham	hardingham	PROPN
fnp-3806	2369	3	ge	ge	PROPN
fnp-3806	2369	4	,	,	PUNCT
fnp-3806	2369	5	bading	bade	VERB
fnp-3806	2369	6	h.	h.	PROPN
fnp-3806	2369	7	synaptic	synaptic	ADJ
fnp-3806	2369	8	versus	versus	ADP
fnp-3806	2369	9	extrasynaptic	extrasynaptic	ADJ
fnp-3806	2369	10	nmda	nmda	ADJ
fnp-3806	2369	11	receptor	receptor	NOUN
fnp-3806	2369	12	signalling	signal	VERB
fnp-3806	2369	13	:	:	PUNCT
fnp-3806	2369	14	implications	implication	NOUN
fnp-3806	2369	15	for	for	ADP
fnp-3806	2369	16	neurodegenerative	neurodegenerative	ADJ
fnp-3806	2369	17	disorders	disorder	NOUN
fnp-3806	2369	18	.	.	PUNCT
fnp-3806	2370	1	nat	nat	PROPN
fnp-3806	2370	2	rev	rev	PROPN
fnp-3806	2370	3	neurosci	neurosci	PROPN
fnp-3806	2370	4	2010	2010	NUM
fnp-3806	2370	5	;	;	PUNCT
fnp-3806	2370	6	11	11	NUM
fnp-3806	2370	7	:	:	PUNCT
fnp-3806	2370	8	682	682	NUM
fnp-3806	2370	9	-	-	SYM
fnp-3806	2370	10	696	696	NUM
fnp-3806	2370	11	.	.	PUNCT
fnp-3806	2371	1	https://doi.org/10.1038/nrn2911	https://doi.org/10.1038/nrn2911	NOUN
fnp-3806	2371	2	mufson	mufson	NOUN
fnp-3806	2371	3	ej	ej	PROPN
fnp-3806	2371	4	,	,	PUNCT
fnp-3806	2371	5	kordower	kordower	PROPN
fnp-3806	2371	6	jh	jh	PROPN
fnp-3806	2371	7	.	.	PUNCT
fnp-3806	2372	1	cholinergic	cholinergic	ADJ
fnp-3806	2372	2	basal	basal	NOUN
fnp-3806	2372	3	forebtrain	forebtrain	NOUN
fnp-3806	2372	4	system	system	NOUN
fnp-3806	2372	5	in	in	ADP
fnp-3806	2372	6	the	the	DET
fnp-3806	2372	7	primate	primate	NOUN
fnp-3806	2372	8	central	central	ADJ
fnp-3806	2372	9	nervous	nervous	ADJ
fnp-3806	2372	10	system	system	NOUN
fnp-3806	2372	11	:	:	PUNCT
fnp-3806	2372	12	anatomy	anatomy	NOUN
fnp-3806	2372	13	,	,	PUNCT
fnp-3806	2372	14	connectivity	connectivity	NOUN
fnp-3806	2372	15	,	,	PUNCT
fnp-3806	2372	16	neurochemistry	neurochemistry	NOUN
fnp-3806	2372	17	,	,	PUNCT
fnp-3806	2372	18	aging	aging	NOUN
fnp-3806	2372	19	,	,	PUNCT
fnp-3806	2372	20	dementia	dementia	NOUN
fnp-3806	2372	21	,	,	PUNCT
fnp-3806	2372	22	and	and	CCONJ
fnp-3806	2372	23	experimental	experimental	ADJ
fnp-3806	2372	24	therapeutics	therapeutic	NOUN
fnp-3806	2372	25	.	.	PUNCT
fnp-3806	2373	1	in	in	ADP
fnp-3806	2373	2	:	:	PUNCT
fnp-3806	2373	3	functional	functional	ADJ
fnp-3806	2373	4	neurobiology	neurobiology	NOUN
fnp-3806	2373	5	of	of	ADP
fnp-3806	2373	6	aging	aging	NOUN
fnp-3806	2373	7	.	.	PUNCT
fnp-3806	2374	1	hof	hof	PROPN
fnp-3806	2374	2	pr	pr	PROPN
fnp-3806	2374	3	,	,	PUNCT
fnp-3806	2374	4	mobbs	mobbs	PROPN
fnp-3806	2374	5	cv	cv	PROPN
fnp-3806	2374	6	(	(	PUNCT
fnp-3806	2374	7	eds	ed	NOUN
fnp-3806	2374	8	.	.	PUNCT
fnp-3806	2374	9	)	)	PUNCT
fnp-3806	2375	1	academic	academic	ADJ
fnp-3806	2375	2	press	press	NOUN
fnp-3806	2375	3	2001	2001	NUM
fnp-3806	2375	4	,	,	PUNCT
fnp-3806	2375	5	pp	pp	CCONJ
fnp-3806	2375	6	:	:	PUNCT
fnp-3806	2375	7	243	243	NUM
fnp-3806	2375	8	-	-	SYM
fnp-3806	2375	9	281	281	NUM
fnp-3806	2375	10	mishizen	mishizen	NOUN
fnp-3806	2375	11	a	a	PRON
fnp-3806	2375	12	,	,	PUNCT
fnp-3806	2375	13	ikonomovic	ikonomovic	PROPN
fnp-3806	2375	14	m	m	PROPN
fnp-3806	2375	15	,	,	PUNCT
fnp-3806	2375	16	armstrong	armstrong	PROPN
fnp-3806	2375	17	dm	dm	PROPN
fnp-3806	2375	18	.	.	PUNCT
fnp-3806	2375	19	glutamate	glutamate	ADJ
fnp-3806	2375	20	receptors	receptor	NOUN
fnp-3806	2375	21	in	in	ADP
fnp-3806	2375	22	aging	aging	NOUN
fnp-3806	2375	23	and	and	CCONJ
fnp-3806	2375	24	alzheimer	alzheimer	NOUN
fnp-3806	2375	25	’s	’s	PART
fnp-3806	2375	26	disease	disease	NOUN
fnp-3806	2375	27	.	.	PUNCT
fnp-3806	2376	1	in	in	ADP
fnp-3806	2376	2	:	:	PUNCT
fnp-3806	2376	3	functional	functional	ADJ
fnp-3806	2376	4	neurobiology	neurobiology	NOUN
fnp-3806	2376	5	of	of	ADP
fnp-3806	2376	6	aging	aging	NOUN
fnp-3806	2376	7	.	.	PUNCT
fnp-3806	2377	1	hof	hof	PROPN
fnp-3806	2377	2	pr	pr	PROPN
fnp-3806	2377	3	,	,	PUNCT
fnp-3806	2377	4	mobbs	mobbs	PROPN
fnp-3806	2377	5	cv	cv	PROPN
fnp-3806	2377	6	(	(	PUNCT
fnp-3806	2377	7	eds	ed	NOUN
fnp-3806	2377	8	.	.	PUNCT
fnp-3806	2377	9	)	)	PUNCT
fnp-3806	2377	10	.	.	PUNCT
fnp-3806	2378	1	academic	academic	ADJ
fnp-3806	2378	2	press	press	NOUN
fnp-3806	2378	3	2001	2001	NUM
fnp-3806	2378	4	,	,	PUNCT
fnp-3806	2378	5	pp	pp	CCONJ
fnp-3806	2378	6	:	:	PUNCT
fnp-3806	2378	7	283	283	NUM
fnp-3806	2378	8	-	-	SYM
fnp-3806	2378	9	314	314	NUM
fnp-3806	2378	10	wang	wang	PROPN
fnp-3806	2378	11	r	r	PROPN
fnp-3806	2378	12	,	,	PUNCT
fnp-3806	2378	13	reddy	reddy	PROPN
fnp-3806	2378	14	ph	ph	PROPN
fnp-3806	2378	15	.	.	PROPN
fnp-3806	2378	16	role	role	NOUN
fnp-3806	2378	17	of	of	ADP
fnp-3806	2378	18	glutamate	glutamate	NOUN
fnp-3806	2378	19	and	and	CCONJ
fnp-3806	2378	20	nmda	nmda	ADJ
fnp-3806	2378	21	receptors	receptor	NOUN
fnp-3806	2378	22	in	in	ADP
fnp-3806	2378	23	alzheimer	alzheimer	PROPN
fnp-3806	2378	24	’s	’s	PART
fnp-3806	2378	25	disease	disease	NOUN
fnp-3806	2378	26	.	.	PUNCT
fnp-3806	2379	1	j	j	PROPN
fnp-3806	2379	2	alzheimers	alzheimers	PROPN
fnp-3806	2379	3	dis	dis	PROPN
fnp-3806	2379	4	2017;57:1041	2017;57:1041	NUM
fnp-3806	2379	5	-	-	PUNCT
fnp-3806	2379	6	1048	1048	NUM
fnp-3806	2379	7	.	.	PUNCT
fnp-3806	2380	1	https://doi.org/10.3233/jad-160763	https://doi.org/10.3233/jad-160763	PROPN
fnp-3806	2380	2	armada	armada	PROPN
fnp-3806	2380	3	-	-	PUNCT
fnp-3806	2380	4	moreira	moreira	PROPN
fnp-3806	2380	5	a	a	PRON
fnp-3806	2380	6	,	,	PUNCT
fnp-3806	2380	7	gomes	gomes	PROPN
fnp-3806	2380	8	ji	ji	PROPN
fnp-3806	2380	9	,	,	PUNCT
fnp-3806	2380	10	pina	pina	PROPN
fnp-3806	2380	11	cc	cc	PROPN
fnp-3806	2380	12	,	,	PUNCT
fnp-3806	2380	13	et	et	PROPN
fnp-3806	2380	14	al	al	PROPN
fnp-3806	2380	15	.	.	PUNCT
fnp-3806	2380	16	going	go	VERB
fnp-3806	2380	17	the	the	DET
fnp-3806	2380	18	extra	extra	ADJ
fnp-3806	2380	19	(	(	PUNCT
fnp-3806	2380	20	synaptic	synaptic	ADJ
fnp-3806	2380	21	)	)	PUNCT
fnp-3806	2380	22	mile	mile	NOUN
fnp-3806	2380	23	:	:	PUNCT
fnp-3806	2380	24	excitotoxicity	excitotoxicity	NOUN
fnp-3806	2380	25	as	as	ADP
fnp-3806	2380	26	the	the	DET
fnp-3806	2380	27	road	road	NOUN
fnp-3806	2380	28	toward	toward	ADP
fnp-3806	2380	29	neurodegenerative	neurodegenerative	ADJ
fnp-3806	2380	30	diseases	disease	NOUN
fnp-3806	2380	31	.	.	PUNCT
fnp-3806	2381	1	front	front	ADJ
fnp-3806	2381	2	cell	cell	NOUN
fnp-3806	2381	3	neurosci	neurosci	NOUN
fnp-3806	2381	4	2020;14:90	2020;14:90	NUM
fnp-3806	2381	5	.	.	PUNCT
fnp-3806	2382	1	https://doi.org/10.3389/fncel.2020.00090	https://doi.org/10.3389/fncel.2020.00090	PROPN
fnp-3806	2382	2	šimić	šimić	VERB
fnp-3806	2382	3	g	g	NOUN
fnp-3806	2382	4	,	,	PUNCT
fnp-3806	2382	5	babić	babić	NOUN
fnp-3806	2382	6	leko	leko	PROPN
fnp-3806	2382	7	m	m	PROPN
fnp-3806	2382	8	,	,	PUNCT
fnp-3806	2382	9	wray	wray	PROPN
fnp-3806	2382	10	s	s	PROPN
fnp-3806	2382	11	,	,	PUNCT
fnp-3806	2382	12	et	et	PROPN
fnp-3806	2382	13	al	al	PROPN
fnp-3806	2382	14	.	.	PROPN
fnp-3806	2382	15	monoaminergic	monoaminergic	PROPN
fnp-3806	2382	16	neuropathology	neuropathology	NOUN
fnp-3806	2382	17	in	in	ADP
fnp-3806	2382	18	alzheimer	alzheimer	PROPN
fnp-3806	2382	19	’s	’s	PART
fnp-3806	2382	20	disease	disease	NOUN
fnp-3806	2382	21	.	.	PUNCT
fnp-3806	2383	1	prog	prog	PROPN
fnp-3806	2383	2	neurobiol	neurobiol	PROPN
fnp-3806	2383	3	2017;151:101	2017;151:101	NUM
fnp-3806	2383	4	-	-	SYM
fnp-3806	2383	5	138	138	NUM
fnp-3806	2383	6	.	.	PUNCT
fnp-3806	2384	1	https://doi.org/10.1016/j.pneurobio.2016.04.001	https://doi.org/10.1016/j.pneurobio.2016.04.001	PROPN
fnp-3806	2384	2	sharma	sharma	PROPN
fnp-3806	2384	3	k	k	PROPN
fnp-3806	2384	4	,	,	PUNCT
fnp-3806	2384	5	pradhan	pradhan	PROPN
fnp-3806	2384	6	s	s	PROPN
fnp-3806	2384	7	,	,	PUNCT
fnp-3806	2384	8	duffy	duffy	PROPN
fnp-3806	2384	9	l	l	PROPN
fnp-3806	2384	10	,	,	PUNCT
fnp-3806	2384	11	et	et	PROPN
fnp-3806	2384	12	al	al	PROPN
fnp-3806	2384	13	.	.	PUNCT
fnp-3806	2384	14	role	role	NOUN
fnp-3806	2384	15	of	of	ADP
fnp-3806	2384	16	receptors	receptor	NOUN
fnp-3806	2384	17	in	in	ADP
fnp-3806	2384	18	relation	relation	NOUN
fnp-3806	2384	19	to	to	ADP
fnp-3806	2384	20	plaques	plaque	NOUN
fnp-3806	2384	21	and	and	CCONJ
fnp-3806	2384	22	tanglers	tangler	NOUN
fnp-3806	2384	23	in	in	ADP
fnp-3806	2384	24	alzheimer	alzheimer	PROPN
fnp-3806	2384	25	’s	’s	PART
fnp-3806	2384	26	disease	disease	NOUN
fnp-3806	2384	27	pathology	pathology	PROPN
fnp-3806	2384	28	.	.	PUNCT
fnp-3806	2385	1	int	int	PROPN
fnp-3806	2385	2	j	j	PROPN
fnp-3806	2385	3	mol	mol	ADP
fnp-3806	2385	4	sci	sci	PROPN
fnp-3806	2385	5	2021;22:12987	2021;22:12987	NUM
fnp-3806	2385	6	.	.	PUNCT
fnp-3806	2385	7	https://doi.org/10.3390/ijms222312987	https://doi.org/10.3390/ijms222312987	PROPN
fnp-3806	2386	1	cai	cai	PROPN
fnp-3806	2387	1	z	z	PROPN
fnp-3806	2387	2	,	,	PUNCT
fnp-3806	2387	3	ratka	ratka	PROPN
fnp-3806	2387	4	a.	a.	NOUN
fnp-3806	2387	5	opioid	opioid	PROPN
fnp-3806	2387	6	system	system	NOUN
fnp-3806	2387	7	and	and	CCONJ
fnp-3806	2387	8	alzheimer	alzheimer	PROPN
fnp-3806	2387	9	's	's	PART
fnp-3806	2387	10	disease	disease	NOUN
fnp-3806	2387	11	.	.	PUNCT
fnp-3806	2388	1	neuromolecular	neuromolecular	ADJ
fnp-3806	2388	2	med	med	ADJ
fnp-3806	2388	3	2012;14:91	2012;14:91	NUM
fnp-3806	2388	4	-	-	PUNCT
fnp-3806	2388	5	111	111	NUM
fnp-3806	2388	6	.	.	PUNCT
fnp-3806	2388	7	https://doi.org/10.1007/s12017-012-8180-3	https://doi.org/10.1007/s12017-012-8180-3	PROPN
fnp-3806	2388	8	morley	morley	PROPN
fnp-3806	2388	9	je	je	PROPN
fnp-3806	2388	10	.	.	PUNCT
fnp-3806	2388	11	peptides	peptide	NOUN
fnp-3806	2388	12	and	and	CCONJ
fnp-3806	2388	13	aging	aging	NOUN
fnp-3806	2388	14	:	:	PUNCT
fnp-3806	2388	15	their	their	PRON
fnp-3806	2388	16	role	role	NOUN
fnp-3806	2388	17	in	in	ADP
fnp-3806	2388	18	anorexia	anorexia	NOUN
fnp-3806	2388	19	and	and	CCONJ
fnp-3806	2388	20	memory	memory	NOUN
fnp-3806	2388	21	.	.	PUNCT
fnp-3806	2389	1	peptides	peptide	NOUN
fnp-3806	2389	2	2015;72:112	2015;72:112	PROPN
fnp-3806	2389	3	-	-	SYM
fnp-3806	2389	4	118	118	NUM
fnp-3806	2389	5	.	.	PUNCT
fnp-3806	2390	1	https://doi.org/10.1016/j.peptides	https://doi.org/10.1016/j.peptide	NOUN
fnp-3806	2390	2	2015.04.007	2015.04.007	NUM
fnp-3806	2390	3	.	.	PUNCT
fnp-3806	2391	1	henry	henry	PROPN
fnp-3806	2391	2	ms	ms	PROPN
fnp-3806	2391	3	,	,	PUNCT
fnp-3806	2391	4	gendron	gendron	PROPN
fnp-3806	2391	5	l	l	NOUN
fnp-3806	2391	6	,	,	PUNCT
fnp-3806	2391	7	tremblay	tremblay	VERB
fnp-3806	2391	8	me	i	PRON
fnp-3806	2391	9	,	,	PUNCT
fnp-3806	2391	10	et	et	PROPN
fnp-3806	2391	11	al	al	PROPN
fnp-3806	2391	12	.	.	PROPN
fnp-3806	2391	13	enkephalins	enkephalin	VERB
fnp-3806	2391	14	:	:	PUNCT
fnp-3806	2391	15	endogenous	endogenous	ADJ
fnp-3806	2391	16	analgesics	analgesic	NOUN
fnp-3806	2391	17	with	with	ADP
fnp-3806	2391	18	an	an	DET
fnp-3806	2391	19	emerging	emerge	VERB
fnp-3806	2391	20	role	role	NOUN
fnp-3806	2391	21	in	in	ADP
fnp-3806	2391	22	stress	stress	NOUN
fnp-3806	2391	23	resilience	resilience	NOUN
fnp-3806	2391	24	.	.	PUNCT
fnp-3806	2392	1	neural	neural	ADJ
fnp-3806	2392	2	plast	plast	PROPN
fnp-3806	2392	3	2017;2017:1546125	2017;2017:1546125	NUM
fnp-3806	2392	4	.	.	PUNCT
fnp-3806	2393	1	https://doi.org/10.1155/2017/154612	https://doi.org/10.1155/2017/154612	PROPN
fnp-3806	2393	2	valentino	valentino	PROPN
fnp-3806	2393	3	rj	rj	PROPN
fnp-3806	2393	4	,	,	PUNCT
fnp-3806	2393	5	volkow	volkow	PROPN
fnp-3806	2393	6	nd	nd	PRON
fnp-3806	2393	7	.	.	PUNCT
fnp-3806	2394	1	untangling	untangle	VERB
fnp-3806	2394	2	the	the	DET
fnp-3806	2394	3	complexity	complexity	NOUN
fnp-3806	2394	4	of	of	ADP
fnp-3806	2394	5	opioid	opioid	ADJ
fnp-3806	2394	6	receptor	receptor	NOUN
fnp-3806	2394	7	function	function	NOUN
fnp-3806	2394	8	.	.	PUNCT
fnp-3806	2395	1	neuropsychopharmacology	neuropsychopharmacology	PROPN
fnp-3806	2395	2	2018;43:2514	2018;43:2514	PROPN
fnp-3806	2395	3	-	-	SYM
fnp-3806	2395	4	2520	2520	NUM
fnp-3806	2395	5	.	.	PUNCT
fnp-3806	2396	1	https://doi.org/10.1038/s41386-018-0225-3	https://doi.org/10.1038/s41386-018-0225-3	PROPN
fnp-3806	2396	2	garcia	garcia	PROPN
fnp-3806	2396	3	-	-	PUNCT
fnp-3806	2396	4	esparcia	esparcia	PROPN
fnp-3806	2396	5	p	p	NOUN
fnp-3806	2396	6	,	,	PUNCT
fnp-3806	2396	7	schlüter	schlüter	NOUN
fnp-3806	2396	8	a	a	PRON
fnp-3806	2396	9	,	,	PUNCT
fnp-3806	2396	10	carmona	carmona	PROPN
fnp-3806	2396	11	m	m	PROPN
fnp-3806	2396	12	,	,	PUNCT
fnp-3806	2396	13	et	et	PROPN
fnp-3806	2396	14	al	al	PROPN
fnp-3806	2396	15	.	.	PROPN
fnp-3806	2397	1	functional	functional	ADJ
fnp-3806	2397	2	genomics	genomic	NOUN
fnp-3806	2397	3	reveals	reveal	VERB
fnp-3806	2397	4	dysregulation	dysregulation	NOUN
fnp-3806	2397	5	of	of	ADP
fnp-3806	2397	6	cortical	cortical	ADJ
fnp-3806	2397	7	olfactory	olfactory	ADJ
fnp-3806	2397	8	receptors	receptor	NOUN
fnp-3806	2397	9	in	in	ADP
fnp-3806	2397	10	parkinson	parkinson	NOUN
fnp-3806	2397	11	disease	disease	NOUN
fnp-3806	2397	12	:	:	PUNCT
fnp-3806	2397	13	novel	novel	ADJ
fnp-3806	2397	14	putative	putative	ADJ
fnp-3806	2397	15	chemoreceptors	chemoreceptor	NOUN
fnp-3806	2397	16	in	in	ADP
fnp-3806	2397	17	the	the	DET
fnp-3806	2397	18	human	human	ADJ
fnp-3806	2397	19	brain	brain	NOUN
fnp-3806	2397	20	.	.	PUNCT
fnp-3806	2398	1	j	j	PROPN
fnp-3806	2398	2	neuropathol	neuropathol	PROPN
fnp-3806	2398	3	exp	exp	PROPN
fnp-3806	2398	4	neurol	neurol	PROPN
fnp-3806	2398	5	2013;72:524	2013;72:524	PROPN
fnp-3806	2398	6	-	-	SYM
fnp-3806	2398	7	539	539	NUM
fnp-3806	2398	8	.	.	PUNCT
fnp-3806	2399	1	https://doi.org/10.1097/nen.0b013e318294fd76	https://doi.org/10.1097/nen.0b013e318294fd76	PROPN
fnp-3806	2399	2	ferrer	ferrer	PROPN
fnp-3806	2399	3	i	i	PROPN
fnp-3806	2399	4	,	,	PUNCT
fnp-3806	2399	5	garcia	garcia	PROPN
fnp-3806	2399	6	-	-	PUNCT
fnp-3806	2399	7	esparcia	esparcia	PROPN
fnp-3806	2399	8	p	p	NOUN
fnp-3806	2399	9	,	,	PUNCT
fnp-3806	2399	10	carmona	carmona	PROPN
fnp-3806	2399	11	m	m	PROPN
fnp-3806	2399	12	,	,	PUNCT
fnp-3806	2399	13	et	et	PROPN
fnp-3806	2399	14	al	al	PROPN
fnp-3806	2399	15	.	.	PUNCT
fnp-3806	2400	1	olfactory	olfactory	ADJ
fnp-3806	2400	2	receptors	receptor	NOUN
fnp-3806	2400	3	in	in	ADP
fnp-3806	2400	4	non	non	ADJ
fnp-3806	2400	5	-	-	ADJ
fnp-3806	2400	6	chemosensory	chemosensory	ADJ
fnp-3806	2400	7	organs	organ	NOUN
fnp-3806	2400	8	:	:	PUNCT
fnp-3806	2400	9	the	the	DET
fnp-3806	2400	10	nervous	nervous	ADJ
fnp-3806	2400	11	system	system	NOUN
fnp-3806	2400	12	in	in	ADP
fnp-3806	2400	13	health	health	NOUN
fnp-3806	2400	14	and	and	CCONJ
fnp-3806	2400	15	disease	disease	NOUN
fnp-3806	2400	16	front	front	NOUN
fnp-3806	2400	17	aging	age	VERB
fnp-3806	2400	18	neurosci	neurosci	NOUN
fnp-3806	2400	19	2016	2016	NUM
fnp-3806	2400	20	;	;	PUNCT
fnp-3806	2400	21	8:163	8:163	NUM
fnp-3806	2400	22	.	.	PUNCT
fnp-3806	2401	1	https://doi.org/10.3389/fnagi.2016.00163	https://doi.org/10.3389/fnagi.2016.00163	PROPN
fnp-3806	2401	2	carlson	carlson	PROPN
fnp-3806	2401	3	ab	ab	PROPN
fnp-3806	2401	4	,	,	PUNCT
fnp-3806	2401	5	kraus	kraus	PROPN
fnp-3806	2401	6	gp	gp	PROPN
fnp-3806	2401	7	.	.	PUNCT
fnp-3806	2401	8	physiology	physiology	NOUN
fnp-3806	2401	9	,	,	PUNCT
fnp-3806	2401	10	cholinergic	cholinergic	ADJ
fnp-3806	2401	11	receptors	receptor	NOUN
fnp-3806	2401	12	.	.	PUNCT
fnp-3806	2402	1	in	in	ADP
fnp-3806	2402	2	statpearls	statpearl	NOUN
fnp-3806	2402	3	;	;	PUNCT
fnp-3806	2402	4	statpearls	statpearl	NOUN
fnp-3806	2402	5	publishing	publishing	NOUN
fnp-3806	2402	6	:	:	PUNCT
fnp-3806	2402	7	treasure	treasure	NOUN
fnp-3806	2402	8	island	island	NOUN
fnp-3806	2402	9	,	,	PUNCT
fnp-3806	2402	10	fl	fl	PROPN
fnp-3806	2402	11	,	,	PUNCT
fnp-3806	2402	12	usa	usa	PROPN
fnp-3806	2402	13	,	,	PUNCT
fnp-3806	2402	14	2021	2021	NUM
fnp-3806	2402	15	.	.	PUNCT
fnp-3806	2403	1	available	available	ADJ
fnp-3806	2403	2	online	online	ADV
fnp-3806	2403	3	:	:	PUNCT
fnp-3806	2403	4	https://www.ncbi.nlm.nih.gov/books/nbk526134	https://www.ncbi.nlm.nih.gov/books/nbk526134	PROPN
fnp-3806	2403	5	maelicke	maelicke	PROPN
fnp-3806	2403	6	a.	a.	PROPN
fnp-3806	2403	7	allosteric	allosteric	PROPN
fnp-3806	2403	8	modulation	modulation	NOUN
fnp-3806	2403	9	of	of	ADP
fnp-3806	2403	10	nicotinic	nicotinic	ADJ
fnp-3806	2403	11	receptors	receptor	NOUN
fnp-3806	2403	12	as	as	ADP
fnp-3806	2403	13	a	a	DET
fnp-3806	2403	14	treatment	treatment	NOUN
fnp-3806	2403	15	strategy	strategy	NOUN
fnp-3806	2403	16	for	for	ADP
fnp-3806	2403	17	alzheimer	alzheimer	PROPN
fnp-3806	2403	18	’s	’s	PART
fnp-3806	2403	19	disease	disease	NOUN
fnp-3806	2403	20	.	.	PUNCT
fnp-3806	2404	1	dement	dement	PROPN
fnp-3806	2404	2	geriatr	geriatr	PROPN
fnp-3806	2404	3	cogn	cogn	PROPN
fnp-3806	2404	4	disord	disord	PROPN
fnp-3806	2404	5	2000;11:11	2000;11:11	PROPN
fnp-3806	2404	6	-	-	SYM
fnp-3806	2404	7	18	18	NUM
fnp-3806	2404	8	.	.	PUNCT
fnp-3806	2405	1	https://doi.org/10.1159/000051227	https://doi.org/10.1159/000051227	X
fnp-3806	2405	2	cheng	cheng	PROPN
fnp-3806	2405	3	yj	yj	PROPN
fnp-3806	2405	4	,	,	PUNCT
fnp-3806	2405	5	lin	lin	PROPN
fnp-3806	2405	6	ch	ch	PROPN
fnp-3806	2405	7	,	,	PUNCT
fnp-3806	2405	8	lane	lane	PROPN
fnp-3806	2405	9	hy	hy	PROPN
fnp-3806	2405	10	.	.	PUNCT
fnp-3806	2406	1	involvement	involvement	NOUN
fnp-3806	2406	2	of	of	ADP
fnp-3806	2406	3	cholinergic	cholinergic	ADJ
fnp-3806	2406	4	,	,	PUNCT
fnp-3806	2406	5	adrenergic	adrenergic	ADJ
fnp-3806	2406	6	,	,	PUNCT
fnp-3806	2406	7	and	and	CCONJ
fnp-3806	2406	8	glutamatergic	glutamatergic	ADJ
fnp-3806	2406	9	network	network	NOUN
fnp-3806	2406	10	modulation	modulation	NOUN
fnp-3806	2406	11	with	with	ADP
fnp-3806	2406	12	cognitive	cognitive	ADJ
fnp-3806	2406	13	dysfunction	dysfunction	NOUN
fnp-3806	2406	14	in	in	ADP
fnp-3806	2406	15	alzheimer	alzheimer	PROPN
fnp-3806	2406	16	's	's	PART
fnp-3806	2406	17	disease	disease	NOUN
fnp-3806	2406	18	.	.	PUNCT
fnp-3806	2407	1	int	int	PROPN
fnp-3806	2407	2	j	j	PROPN
fnp-3806	2407	3	mol	mol	ADP
fnp-3806	2407	4	sci	sci	PROPN
fnp-3806	2407	5	2021	2021	NUM
fnp-3806	2407	6	;	;	PUNCT
fnp-3806	2407	7	22:2283	22:2283	NUM
fnp-3806	2407	8	.	.	PUNCT
fnp-3806	2408	1	https://doi.org/10.3390/ijms22052283	https://doi.org/10.3390/ijms22052283	PROPN
fnp-3806	2408	2	mufson	mufson	PROPN
fnp-3806	2408	3	ej	ej	PROPN
fnp-3806	2408	4	,	,	PUNCT
fnp-3806	2408	5	bothwell	bothwell	PROPN
fnp-3806	2408	6	m	m	PROPN
fnp-3806	2408	7	,	,	PUNCT
fnp-3806	2408	8	hersh	hersh	PROPN
fnp-3806	2408	9	lb	lb	PROPN
fnp-3806	2408	10	,	,	PUNCT
fnp-3806	2408	11	et	et	PROPN
fnp-3806	2408	12	al	al	PROPN
fnp-3806	2408	13	.	.	PROPN
fnp-3806	2408	14	nerve	nerve	NOUN
fnp-3806	2408	15	growth	growth	NOUN
fnp-3806	2408	16	factor	factor	NOUN
fnp-3806	2408	17	receptor	receptor	NOUN
fnp-3806	2408	18	immunoreactive	immunoreactive	ADJ
fnp-3806	2408	19	profiles	profile	NOUN
fnp-3806	2408	20	in	in	ADP
fnp-3806	2408	21	the	the	DET
fnp-3806	2408	22	normal	normal	ADJ
fnp-3806	2408	23	,	,	PUNCT
fnp-3806	2408	24	aged	aged	ADJ
fnp-3806	2408	25	human	human	ADJ
fnp-3806	2408	26	basal	basal	NOUN
fnp-3806	2408	27	forebrain	forebrain	NOUN
fnp-3806	2408	28	:	:	PUNCT
fnp-3806	2408	29	colocalization	colocalization	NOUN
fnp-3806	2408	30	with	with	ADP
fnp-3806	2408	31	cholinergic	cholinergic	ADJ
fnp-3806	2408	32	neurons	neuron	NOUN
fnp-3806	2408	33	.	.	PUNCT
fnp-3806	2409	1	j	j	PROPN
fnp-3806	2409	2	comp	comp	PROPN
fnp-3806	2409	3	neurol	neurol	PROPN
fnp-3806	2409	4	1989;285:196	1989;285:196	NUM
fnp-3806	2409	5	-	-	SYM
fnp-3806	2409	6	217	217	NUM
fnp-3806	2409	7	.	.	PUNCT
fnp-3806	2410	1	https://doi.org/10.1002/cne.902850204	https://doi.org/10.1002/cne.902850204	NOUN
fnp-3806	2410	2	mufson	mufson	NOUN
fnp-3806	2410	3	ej	ej	PROPN
fnp-3806	2410	4	,	,	PUNCT
fnp-3806	2410	5	bothwell	bothwell	PROPN
fnp-3806	2410	6	m	m	PROPN
fnp-3806	2410	7	,	,	PUNCT
fnp-3806	2410	8	kordower	kordower	PROPN
fnp-3806	2410	9	jh	jh	PROPN
fnp-3806	2410	10	.	.	PUNCT
fnp-3806	2411	1	loss	loss	NOUN
fnp-3806	2411	2	of	of	ADP
fnp-3806	2411	3	nerve	nerve	NOUN
fnp-3806	2411	4	growth	growth	NOUN
fnp-3806	2411	5	factor	factor	NOUN
fnp-3806	2411	6	receptor	receptor	NOUN
fnp-3806	2411	7	-	-	PUNCT
fnp-3806	2411	8	containing	contain	VERB
fnp-3806	2411	9	neurons	neuron	NOUN
fnp-3806	2411	10	in	in	ADP
fnp-3806	2411	11	alzheimer	alzheimer	PROPN
fnp-3806	2411	12	's	's	PART
fnp-3806	2411	13	disease	disease	NOUN
fnp-3806	2411	14	:	:	PUNCT
fnp-3806	2411	15	a	a	DET
fnp-3806	2411	16	quantitative	quantitative	ADJ
fnp-3806	2411	17	analysis	analysis	NOUN
fnp-3806	2411	18	across	across	ADP
fnp-3806	2411	19	subregions	subregion	NOUN
fnp-3806	2411	20	of	of	ADP
fnp-3806	2411	21	the	the	DET
fnp-3806	2411	22	basal	basal	ADJ
fnp-3806	2411	23	forebrain	forebrain	NOUN
fnp-3806	2411	24	.	.	PUNCT
fnp-3806	2412	1	exp	exp	NOUN
fnp-3806	2412	2	neurol	neurol	PROPN
fnp-3806	2412	3	1989;105:221	1989;105:221	NOUN
fnp-3806	2412	4	-	-	SYM
fnp-3806	2412	5	232	232	NUM
fnp-3806	2412	6	.	.	PUNCT
fnp-3806	2413	1	https://doi.org/10.1016/0014-4886(89)90124-6	https://doi.org/10.1016/0014-4886(89)90124-6	PROPN
fnp-3806	2413	2	kordower	kordower	PROPN
fnp-3806	2413	3	jh	jh	PROPN
fnp-3806	2413	4	,	,	PUNCT
fnp-3806	2413	5	gash	gash	ADJ
fnp-3806	2413	6	dm	dm	NOUN
fnp-3806	2413	7	,	,	PUNCT
fnp-3806	2413	8	bothwell	bothwell	PROPN
fnp-3806	2413	9	m	m	PROPN
fnp-3806	2413	10	,	,	PUNCT
fnp-3806	2413	11	et	et	PROPN
fnp-3806	2413	12	al	al	PROPN
fnp-3806	2413	13	.	.	PROPN
fnp-3806	2413	14	nerve	nerve	NOUN
fnp-3806	2413	15	growth	growth	NOUN
fnp-3806	2413	16	factor	factor	NOUN
fnp-3806	2413	17	receptor	receptor	NOUN
fnp-3806	2413	18	and	and	CCONJ
fnp-3806	2413	19	choline	choline	NOUN
fnp-3806	2413	20	acetyltransferase	acetyltransferase	NOUN
fnp-3806	2413	21	remain	remain	VERB
fnp-3806	2413	22	colocalized	colocalize	VERB
fnp-3806	2413	23	in	in	ADP
fnp-3806	2413	24	the	the	DET
fnp-3806	2413	25	nucleus	nucleus	ADJ
fnp-3806	2413	26	basalis	basali	NOUN
fnp-3806	2413	27	(	(	PUNCT
fnp-3806	2413	28	ch4	ch4	NOUN
fnp-3806	2413	29	)	)	PUNCT
fnp-3806	2413	30	of	of	ADP
fnp-3806	2413	31	alzheimer	alzheimer	PROPN
fnp-3806	2413	32	's	's	PART
fnp-3806	2413	33	patients	patient	NOUN
fnp-3806	2413	34	.	.	PUNCT
fnp-3806	2414	1	neurobiol	neurobiol	VERB
fnp-3806	2414	2	aging	age	VERB
fnp-3806	2414	3	1989;10:67	1989;10:67	NUM
fnp-3806	2414	4	-	-	SYM
fnp-3806	2414	5	74	74	NUM
fnp-3806	2414	6	.	.	PUNCT
fnp-3806	2415	1	https://doi.org/10.1016/s0197-4580(89)80013-2	https://doi.org/10.1016/s0197-4580(89)80013-2	PROPN
fnp-3806	2415	2	mufson	mufson	NOUN
fnp-3806	2415	3	ej	ej	PROPN
fnp-3806	2415	4	,	,	PUNCT
fnp-3806	2415	5	kordower	kordower	PROPN
fnp-3806	2415	6	ej	ej	PROPN
fnp-3806	2415	7	.	.	PROPN
fnp-3806	2415	8	nerve	nerve	NOUN
fnp-3806	2415	9	growth	growth	NOUN
fnp-3806	2415	10	factor	factor	NOUN
fnp-3806	2415	11	in	in	ADP
fnp-3806	2415	12	alzheimer	alzheimer	PROPN
fnp-3806	2415	13	’s	’s	PART
fnp-3806	2415	14	disease	disease	NOUN
fnp-3806	2415	15	.	.	PUNCT
fnp-3806	2416	1	in	in	ADP
fnp-3806	2416	2	cerebral	cerebral	ADJ
fnp-3806	2416	3	cortex	cortex	NOUN
fnp-3806	2416	4	,	,	PUNCT
fnp-3806	2416	5	peters	peters	PROPN
fnp-3806	2416	6	aa	aa	PROPN
fnp-3806	2416	7	,	,	PUNCT
fnp-3806	2416	8	morrison	morrison	PROPN
fnp-3806	2416	9	jh	jh	PROPN
fnp-3806	2416	10	,	,	PUNCT
fnp-3806	2416	11	eds	eds	PROPN
fnp-3806	2416	12	.	.	PUNCT
fnp-3806	2417	1	kluver	kluver	NOUN
fnp-3806	2417	2	academic	academic	NOUN
fnp-3806	2417	3	/	/	SYM
fnp-3806	2417	4	plenum	plenum	PROPN
fnp-3806	2417	5	,	,	PUNCT
fnp-3806	2417	6	new	new	PROPN
fnp-3806	2417	7	york	york	PROPN
fnp-3806	2417	8	,	,	PUNCT
fnp-3806	2417	9	1999;14:681	1999;14:681	NUM
fnp-3806	2417	10	-	-	SYM
fnp-3806	2417	11	731	731	NUM
fnp-3806	2417	12	whitehouse	whitehouse	NOUN
fnp-3806	2417	13	pj	pj	PROPN
fnp-3806	2417	14	,	,	PUNCT
fnp-3806	2417	15	price	price	NOUN
fnp-3806	2417	16	dl	dl	PROPN
fnp-3806	2417	17	,	,	PUNCT
fnp-3806	2417	18	struble	struble	ADJ
fnp-3806	2417	19	rg	rg	NOUN
fnp-3806	2417	20	,	,	PUNCT
fnp-3806	2418	1	et	et	PROPN
fnp-3806	2418	2	al	al	PROPN
fnp-3806	2418	3	.	.	PROPN
fnp-3806	2418	4	alzheimer	alzheimer	PROPN
fnp-3806	2418	5	's	's	PART
fnp-3806	2418	6	disease	disease	NOUN
fnp-3806	2418	7	and	and	CCONJ
fnp-3806	2418	8	senile	senile	ADJ
fnp-3806	2418	9	dementia	dementia	NOUN
fnp-3806	2418	10	:	:	PUNCT
fnp-3806	2418	11	loss	loss	NOUN
fnp-3806	2418	12	of	of	ADP
fnp-3806	2418	13	neurons	neuron	NOUN
fnp-3806	2418	14	in	in	ADP
fnp-3806	2418	15	the	the	DET
fnp-3806	2418	16	basal	basal	ADJ
fnp-3806	2418	17	forebrain	forebrain	NOUN
fnp-3806	2418	18	.	.	PUNCT
fnp-3806	2419	1	science	science	NOUN
fnp-3806	2419	2	1982	1982	NUM
fnp-3806	2419	3	;	;	PUNCT
fnp-3806	2419	4	215:1237	215:1237	NUM
fnp-3806	2419	5	-	-	SYM
fnp-3806	2419	6	1239	1239	NUM
fnp-3806	2419	7	.	.	PUNCT
fnp-3806	2420	1	https://doi.org/10.1126/science.7058341	https://doi.org/10.1126/science.7058341	PROPN
fnp-3806	2420	2	dekosky	dekosky	PROPN
fnp-3806	2420	3	st	st	PROPN
fnp-3806	2420	4	,	,	PUNCT
fnp-3806	2420	5	ikonomovic	ikonomovic	PROPN
fnp-3806	2420	6	md	md	PROPN
fnp-3806	2420	7	,	,	PUNCT
fnp-3806	2420	8	styren	styren	PROPN
fnp-3806	2420	9	sd	sd	PROPN
fnp-3806	2420	10	,	,	PUNCT
fnp-3806	2420	11	et	et	PROPN
fnp-3806	2420	12	al	al	PROPN
fnp-3806	2420	13	.	.	PROPN
fnp-3806	2420	14	upregulation	upregulation	NOUN
fnp-3806	2420	15	of	of	ADP
fnp-3806	2420	16	choline	choline	NOUN
fnp-3806	2420	17	acetyltransferase	acetyltransferase	NOUN
fnp-3806	2420	18	activity	activity	NOUN
fnp-3806	2420	19	in	in	ADP
fnp-3806	2420	20	hippocampus	hippocampus	NOUN
fnp-3806	2420	21	and	and	CCONJ
fnp-3806	2420	22	frontal	frontal	ADJ
fnp-3806	2420	23	cortex	cortex	NOUN
fnp-3806	2420	24	of	of	ADP
fnp-3806	2420	25	elderly	elderly	ADJ
fnp-3806	2420	26	subjects	subject	NOUN
fnp-3806	2420	27	with	with	ADP
fnp-3806	2420	28	mild	mild	ADJ
fnp-3806	2420	29	cognitive	cognitive	ADJ
fnp-3806	2420	30	impairment	impairment	NOUN
fnp-3806	2420	31	.	.	PUNCT
fnp-3806	2421	1	ann	ann	PROPN
fnp-3806	2421	2	neurol	neurol	PROPN
fnp-3806	2421	3	2002;51:145	2002;51:145	PROPN
fnp-3806	2421	4	-	-	SYM
fnp-3806	2421	5	155	155	NUM
fnp-3806	2421	6	.	.	PUNCT
fnp-3806	2422	1	https://doi.org/10.1002/ana.10069	https://doi.org/10.1002/ana.10069	PROPN
fnp-3806	2422	2	tiernan	tiernan	PROPN
fnp-3806	2422	3	ct	ct	PROPN
fnp-3806	2422	4	,	,	PUNCT
fnp-3806	2422	5	ginsberg	ginsberg	PROPN
fnp-3806	2422	6	sd	sd	PROPN
fnp-3806	2422	7	,	,	PUNCT
fnp-3806	2422	8	he	he	PRON
fnp-3806	2422	9	b	b	NUM
fnp-3806	2422	10	,	,	PUNCT
fnp-3806	2422	11	et	et	PROPN
fnp-3806	2422	12	al	al	PROPN
fnp-3806	2422	13	.	.	PROPN
fnp-3806	2423	1	pretangle	pretangle	VERB
fnp-3806	2423	2	pathology	pathology	NOUN
fnp-3806	2423	3	within	within	ADP
fnp-3806	2423	4	cholinergic	cholinergic	ADJ
fnp-3806	2423	5	nucleus	nucleus	NOUN
fnp-3806	2423	6	basalis	basalis	PROPN
fnp-3806	2423	7	neurons	neuron	NOUN
fnp-3806	2423	8	coincides	coincide	VERB
fnp-3806	2423	9	with	with	ADP
fnp-3806	2423	10	neurotrophic	neurotrophic	ADJ
fnp-3806	2423	11	and	and	CCONJ
fnp-3806	2423	12	neurotransmitter	neurotransmitter	NOUN
fnp-3806	2423	13	receptor	receptor	NOUN
fnp-3806	2423	14	gene	gene	NOUN
fnp-3806	2423	15	dysregulation	dysregulation	NOUN
fnp-3806	2423	16	during	during	ADP
fnp-3806	2423	17	the	the	DET
fnp-3806	2423	18	progression	progression	NOUN
fnp-3806	2423	19	of	of	ADP
fnp-3806	2423	20	alzheimer	alzheimer	PROPN
fnp-3806	2423	21	's	's	PART
fnp-3806	2423	22	disease	disease	NOUN
fnp-3806	2423	23	.	.	PUNCT
fnp-3806	2424	1	neurobiol	neurobiol	PROPN
fnp-3806	2424	2	dis	dis	PROPN
fnp-3806	2424	3	2018;117:125	2018;117:125	NUM
fnp-3806	2424	4	-	-	SYM
fnp-3806	2424	5	136	136	NUM
fnp-3806	2424	6	.	.	PUNCT
fnp-3806	2425	1	https://doi.org/10.1016/j.nbd.2018.05.021	https://doi.org/10.1016/j.nbd.2018.05.021	PROPN
fnp-3806	2425	2	ferreira	ferreira	PROPN
fnp-3806	2425	3	-	-	PUNCT
fnp-3806	2425	4	vieira	vieira	PROPN
fnp-3806	2425	5	th	th	PROPN
fnp-3806	2425	6	,	,	PUNCT
fnp-3806	2425	7	guimaraes	guimaraes	PROPN
fnp-3806	2425	8	i	i	PROPN
fnp-3806	2425	9	m	m	PROPN
fnp-3806	2425	10	,	,	PUNCT
fnp-3806	2425	11	silva	silva	PROPN
fnp-3806	2425	12	fr	fr	PROPN
fnp-3806	2425	13	,	,	PUNCT
fnp-3806	2426	1	et	et	PROPN
fnp-3806	2426	2	al	al	PROPN
fnp-3806	2426	3	.	.	PROPN
fnp-3806	2426	4	alzheimer	alzheimer	PROPN
fnp-3806	2426	5	’s	’s	PART
fnp-3806	2426	6	disease	disease	NOUN
fnp-3806	2426	7	:	:	PUNCT
fnp-3806	2426	8	targeting	target	VERB
fnp-3806	2426	9	the	the	DET
fnp-3806	2426	10	cholinergic	cholinergic	ADJ
fnp-3806	2426	11	system	system	NOUN
fnp-3806	2426	12	.	.	PUNCT
fnp-3806	2427	1	curr	curr	PROPN
fnp-3806	2427	2	neuropharmacol	neuropharmacol	PROPN
fnp-3806	2427	3	2016;14:101	2016;14:101	PROPN
fnp-3806	2427	4	-	-	PUNCT
fnp-3806	2427	5	115	115	NUM
fnp-3806	2427	6	.	.	PUNCT
fnp-3806	2428	1	https://doi.org/10.2174/1570159x13666150716165726	https://doi.org/10.2174/1570159x13666150716165726	PROPN
fnp-3806	2428	2	perry	perry	PROPN
fnp-3806	2428	3	ek	ek	PROPN
fnp-3806	2428	4	,	,	PUNCT
fnp-3806	2428	5	morris	morris	PROPN
fnp-3806	2428	6	cm	cm	PROPN
fnp-3806	2428	7	,	,	PUNCT
fnp-3806	2428	8	court	court	PROPN
fnp-3806	2428	9	ja	ja	PROPN
fnp-3806	2428	10	,	,	PUNCT
fnp-3806	2428	11	et	et	PROPN
fnp-3806	2428	12	al	al	PROPN
fnp-3806	2428	13	.	.	PROPN
fnp-3806	2428	14	alteration	alteration	NOUN
fnp-3806	2428	15	in	in	ADP
fnp-3806	2428	16	nicotine	nicotine	NOUN
fnp-3806	2428	17	binding	bind	VERB
fnp-3806	2428	18	sites	site	NOUN
fnp-3806	2428	19	in	in	ADP
fnp-3806	2428	20	parkinson	parkinson	NOUN
fnp-3806	2428	21	’s	’s	PART
fnp-3806	2428	22	disease	disease	NOUN
fnp-3806	2428	23	,	,	PUNCT
fnp-3806	2428	24	lewy	lewy	PROPN
fnp-3806	2428	25	body	body	NOUN
fnp-3806	2428	26	dementia	dementia	NOUN
fnp-3806	2428	27	and	and	CCONJ
fnp-3806	2428	28	alzheimer	alzheimer	PROPN
fnp-3806	2428	29	’s	’s	PART
fnp-3806	2428	30	disease	disease	NOUN
fnp-3806	2428	31	:	:	PUNCT
fnp-3806	2428	32	possible	possible	ADJ
fnp-3806	2428	33	index	index	NOUN
fnp-3806	2428	34	of	of	ADP
fnp-3806	2428	35	early	early	ADJ
fnp-3806	2428	36	neuropathology	neuropathology	NOUN
fnp-3806	2428	37	.	.	PUNCT
fnp-3806	2429	1	neuroscience	neuroscience	NOUN
fnp-3806	2429	2	1995;64:385	1995;64:385	PROPN
fnp-3806	2429	3	-	-	SYM
fnp-3806	2429	4	395	395	NUM
fnp-3806	2429	5	.	.	PUNCT
fnp-3806	2430	1	https://doi.org/10.1016/0306-4522(94)00410-7	https://doi.org/10.1016/0306-4522(94)00410-7	PROPN
fnp-3806	2430	2	court	court	PROPN
fnp-3806	2430	3	j	j	PROPN
fnp-3806	2430	4	,	,	PUNCT
fnp-3806	2430	5	martin	martin	PROPN
fnp-3806	2430	6	-	-	PUNCT
fnp-3806	2430	7	ruiz	ruiz	NOUN
fnp-3806	2430	8	c	c	PROPN
fnp-3806	2430	9	,	,	PUNCT
fnp-3806	2430	10	piggott	piggott	PROPN
fnp-3806	2430	11	m	m	PROPN
fnp-3806	2430	12	,	,	PUNCT
fnp-3806	2430	13	et	et	PROPN
fnp-3806	2430	14	al	al	PROPN
fnp-3806	2430	15	.	.	PUNCT
fnp-3806	2430	16	nicotinic	nicotinic	ADJ
fnp-3806	2430	17	receptor	receptor	NOUN
fnp-3806	2430	18	abnormalities	abnormality	NOUN
fnp-3806	2430	19	in	in	ADP
fnp-3806	2430	20	alzheimer	alzheimer	PROPN
fnp-3806	2430	21	’s	’s	PART
fnp-3806	2430	22	disease	disease	NOUN
fnp-3806	2430	23	.	.	PUNCT
fnp-3806	2431	1	biol	biol	PROPN
fnp-3806	2431	2	psychiatry	psychiatry	NOUN
fnp-3806	2431	3	2001;49:175	2001;49:175	PROPN
fnp-3806	2431	4	-	-	SYM
fnp-3806	2431	5	184	184	NUM
fnp-3806	2431	6	.	.	PUNCT
fnp-3806	2432	1	https://doi.org/10.1016/s0006-3223(00)01116-1	https://doi.org/10.1016/s0006-3223(00)01116-1	PROPN
fnp-3806	2432	2	pimlott	pimlott	PROPN
fnp-3806	2432	3	sl	sl	PROPN
fnp-3806	2432	4	,	,	PUNCT
fnp-3806	2432	5	piggott	piggott	PROPN
fnp-3806	2432	6	m	m	PROPN
fnp-3806	2432	7	,	,	PUNCT
fnp-3806	2432	8	owens	owens	PROPN
fnp-3806	2432	9	j	j	PROPN
fnp-3806	2432	10	,	,	PUNCT
fnp-3806	2432	11	et	et	PROPN
fnp-3806	2432	12	al	al	PROPN
fnp-3806	2432	13	.	.	PUNCT
fnp-3806	2432	14	nicotinic	nicotinic	ADJ
fnp-3806	2432	15	acetylcholine	acetylcholine	NOUN
fnp-3806	2432	16	receptor	receptor	NOUN
fnp-3806	2432	17	distribution	distribution	NOUN
fnp-3806	2432	18	in	in	ADP
fnp-3806	2432	19	alzheimer	alzheimer	PROPN
fnp-3806	2432	20	’s	’s	PART
fnp-3806	2432	21	disease	disease	NOUN
fnp-3806	2432	22	,	,	PUNCT
fnp-3806	2432	23	dementia	dementia	NOUN
fnp-3806	2432	24	with	with	ADP
fnp-3806	2432	25	lewy	lewy	PROPN
fnp-3806	2432	26	bodies	body	NOUN
fnp-3806	2432	27	,	,	PUNCT
fnp-3806	2432	28	parkinson	parkinson	NOUN
fnp-3806	2432	29	’s	’s	PART
fnp-3806	2432	30	disease	disease	NOUN
fnp-3806	2432	31	,	,	PUNCT
fnp-3806	2432	32	and	and	CCONJ
fnp-3806	2432	33	vascular	vascular	ADJ
fnp-3806	2432	34	dementia	dementia	NOUN
fnp-3806	2432	35	:	:	PUNCT
fnp-3806	2432	36	in	in	ADP
fnp-3806	2432	37	vitro	vitro	X
fnp-3806	2432	38	binding	bind	VERB
fnp-3806	2432	39	study	study	NOUN
fnp-3806	2432	40	using	use	VERB
fnp-3806	2432	41	5-[125i]-a-85380	5-[125i]-a-85380	NOUN
fnp-3806	2432	42	.	.	PUNCT
fnp-3806	2433	1	neuropsychopharmacology	neuropsychopharmacology	PROPN
fnp-3806	2433	2	2004;29:108	2004;29:108	PROPN
fnp-3806	2433	3	-	-	PUNCT
fnp-3806	2433	4	116	116	NUM
fnp-3806	2433	5	.	.	PUNCT
fnp-3806	2434	1	https://doi.org/10.1038/sj.npp.1300302	https://doi.org/10.1038/sj.npp.1300302	PROPN
fnp-3806	2434	2	shen	shen	PROPN
fnp-3806	2435	1	j	j	PROPN
fnp-3806	2435	2	,	,	PUNCT
fnp-3806	2435	3	wu	wu	PROPN
fnp-3806	2435	4	j.	j.	PROPN
fnp-3806	2435	5	nicotinic	nicotinic	ADJ
fnp-3806	2435	6	cholinergic	cholinergic	NOUN
fnp-3806	2435	7	mechanisms	mechanism	NOUN
fnp-3806	2435	8	in	in	ADP
fnp-3806	2435	9	alzheimer	alzheimer	PROPN
fnp-3806	2435	10	’s	’s	PART
fnp-3806	2435	11	disease	disease	NOUN
fnp-3806	2435	12	.	.	PUNCT
fnp-3806	2436	1	int	int	PROPN
fnp-3806	2436	2	rev	rev	VERB
fnp-3806	2436	3	neurobiol	neurobiol	PROPN
fnp-3806	2436	4	2015;124:275	2015;124:275	NUM
fnp-3806	2436	5	-	-	SYM
fnp-3806	2436	6	292	292	NUM
fnp-3806	2436	7	.	.	PUNCT
fnp-3806	2437	1	https://doi.org/10.1016/bs.irn.2015.08.002	https://doi.org/10.1016/bs.irn.2015.08.002	PROPN
fnp-3806	2437	2	ono	ono	PROPN
fnp-3806	2437	3	k	k	PROPN
fnp-3806	2437	4	,	,	PUNCT
fnp-3806	2437	5	hasegawa	hasegawa	PROPN
fnp-3806	2437	6	k	k	PROPN
fnp-3806	2437	7	,	,	PUNCT
fnp-3806	2437	8	yamada	yamada	PROPN
fnp-3806	2437	9	m	m	PROPN
fnp-3806	2437	10	,	,	PUNCT
fnp-3806	2437	11	et	et	PROPN
fnp-3806	2437	12	al	al	PROPN
fnp-3806	2437	13	.	.	PROPN
fnp-3806	2437	14	nicotine	nicotine	PROPN
fnp-3806	2437	15	breaks	break	VERB
fnp-3806	2437	16	down	down	ADP
fnp-3806	2437	17	preformed	preformed	ADJ
fnp-3806	2437	18	alzheimer	alzheimer	PROPN
fnp-3806	2437	19	’s	’s	PART
fnp-3806	2437	20	β	β	NOUN
fnp-3806	2437	21	-	-	NOUN
fnp-3806	2437	22	amyloid	amyloid	NOUN
fnp-3806	2437	23	fibrils	fibril	NOUN
fnp-3806	2437	24	in	in	ADP
fnp-3806	2437	25	vitro	vitro	X
fnp-3806	2437	26	.	.	PUNCT
fnp-3806	2438	1	biol	biol	PROPN
fnp-3806	2438	2	psychiatry	psychiatry	PROPN
fnp-3806	2438	3	2002	2002	NUM
fnp-3806	2438	4	;	;	PUNCT
fnp-3806	2438	5	52:880	52:880	NUM
fnp-3806	2438	6	-	-	SYM
fnp-3806	2438	7	886	886	NUM
fnp-3806	2438	8	.	.	PUNCT
fnp-3806	2439	1	https://doi.org/10.1016/s0006-3223(02)01417-8	https://doi.org/10.1016/s0006-3223(02)01417-8	PROPN
fnp-3806	2439	2	wang	wang	PROPN
fnp-3806	2439	3	hy	hy	PROPN
fnp-3806	2439	4	,	,	PUNCT
fnp-3806	2439	5	lee	lee	PROPN
fnp-3806	2439	6	dh	dh	PROPN
fnp-3806	2439	7	,	,	PUNCT
fnp-3806	2439	8	d’andrea	d’andrea	PROPN
fnp-3806	2439	9	mr	mr	PROPN
fnp-3806	2439	10	,	,	PUNCT
fnp-3806	2439	11	et	et	PROPN
fnp-3806	2439	12	al	al	PROPN
fnp-3806	2439	13	.	.	PUNCT
fnp-3806	2439	14	β	β	X
fnp-3806	2439	15	-	-	PUNCT
fnp-3806	2439	16	amyloid1	amyloid1	ADV
fnp-3806	2439	17	-	-	PUNCT
fnp-3806	2439	18	42	42	NUM
fnp-3806	2439	19	binds	bind	VERB
fnp-3806	2439	20	to	to	ADP
fnp-3806	2439	21	α7	α7	NOUN
fnp-3806	2439	22	nicotinic	nicotinic	ADJ
fnp-3806	2439	23	acetylcholine	acetylcholine	NOUN
fnp-3806	2439	24	receptor	receptor	NOUN
fnp-3806	2439	25	with	with	ADP
fnp-3806	2439	26	high	high	ADJ
fnp-3806	2439	27	affinity	affinity	NOUN
fnp-3806	2439	28	:	:	PUNCT
fnp-3806	2439	29	implications	implication	NOUN
fnp-3806	2439	30	for	for	ADP
fnp-3806	2439	31	alzheimer	alzheimer	PROPN
fnp-3806	2439	32	’s	’s	PART
fnp-3806	2439	33	disease	disease	NOUN
fnp-3806	2439	34	pathology	pathology	PROPN
fnp-3806	2439	35	.	.	PUNCT
fnp-3806	2440	1	j	j	PROPN
fnp-3806	2440	2	biol	biol	PROPN
fnp-3806	2440	3	chem	chem	NOUN
fnp-3806	2440	4	2000	2000	NUM
fnp-3806	2440	5	;	;	PUNCT
fnp-3806	2440	6	275	275	NUM
fnp-3806	2440	7	:	:	SYM
fnp-3806	2440	8	5626	5626	NUM
fnp-3806	2440	9	-	-	SYM
fnp-3806	2440	10	5632	5632	NUM
fnp-3806	2440	11	.	.	PUNCT
fnp-3806	2441	1	https://doi.org/10.1074/jbc.275.8.5626	https://doi.org/10.1074/jbc.275.8.5626	PROPN
fnp-3806	2441	2	liu	liu	PROPN
fnp-3806	2441	3	q	q	PROPN
fnp-3806	2441	4	,	,	PUNCT
fnp-3806	2441	5	xie	xie	PROPN
fnp-3806	2441	6	x	x	PROPN
fnp-3806	2441	7	,	,	PUNCT
fnp-3806	2441	8	lukas	lukas	PROPN
fnp-3806	2441	9	rj	rj	PROPN
fnp-3806	2441	10	,	,	PUNCT
fnp-3806	2441	11	et	et	PROPN
fnp-3806	2441	12	al	al	PROPN
fnp-3806	2441	13	.	.	PUNCT
fnp-3806	2442	1	a	a	DET
fnp-3806	2442	2	novel	novel	ADJ
fnp-3806	2442	3	nicotinic	nicotinic	ADJ
fnp-3806	2442	4	mechanism	mechanism	NOUN
fnp-3806	2442	5	underlies	underlie	VERB
fnp-3806	2442	6	beta	beta	NOUN
fnp-3806	2442	7	-	-	PUNCT
fnp-3806	2442	8	amyloidinduced	amyloidinduce	VERB
fnp-3806	2442	9	neuronal	neuronal	ADJ
fnp-3806	2442	10	hyperexcitation	hyperexcitation	NOUN
fnp-3806	2442	11	.	.	PUNCT
fnp-3806	2443	1	j	j	PROPN
fnp-3806	2443	2	neurosci	neurosci	PROPN
fnp-3806	2443	3	2013;33:7253	2013;33:7253	NUM
fnp-3806	2443	4	-	-	SYM
fnp-3806	2443	5	7263	7263	NUM
fnp-3806	2443	6	.	.	PUNCT
fnp-3806	2444	1	https://doi.org/10.1523/jneurosci.3235-12.2013	https://doi.org/10.1523/jneurosci.3235-12.2013	PROPN
fnp-3806	2444	2	liu	liu	PROPN
fnp-3806	2444	3	q	q	PROPN
fnp-3806	2444	4	,	,	PUNCT
fnp-3806	2444	5	xie	xie	PROPN
fnp-3806	2444	6	x	x	PROPN
fnp-3806	2444	7	,	,	PUNCT
fnp-3806	2444	8	emadi	emadi	NOUN
fnp-3806	2444	9	s	s	PROPN
fnp-3806	2444	10	,	,	PUNCT
fnp-3806	2444	11	et	et	PROPN
fnp-3806	2444	12	al	al	PROPN
fnp-3806	2444	13	.	.	PUNCT
fnp-3806	2445	1	a	a	DET
fnp-3806	2445	2	novel	novel	ADJ
fnp-3806	2445	3	nicotinic	nicotinic	ADJ
fnp-3806	2445	4	mechanism	mechanism	NOUN
fnp-3806	2445	5	underlies	underlie	VERB
fnp-3806	2445	6	beta	beta	NOUN
fnp-3806	2445	7	-	-	PUNCT
fnp-3806	2445	8	amyloid	amyloid	NOUN
fnp-3806	2445	9	induced	induce	VERB
fnp-3806	2445	10	neurotoxicity	neurotoxicity	NOUN
fnp-3806	2445	11	.	.	PUNCT
fnp-3806	2446	1	neuropharmacology	neuropharmacology	NOUN
fnp-3806	2446	2	2015;97:457	2015;97:457	PROPN
fnp-3806	2446	3	-	-	SYM
fnp-3806	2446	4	463	463	NUM
fnp-3806	2446	5	.	.	PUNCT
fnp-3806	2447	1	https://doi.org/10.1016/j.neuropharm.2015.04.025	https://doi.org/10.1016/j.neuropharm.2015.04.025	PROPN
fnp-3806	2447	2	wang	wang	PROPN
fnp-3806	2447	3	hy	hy	PROPN
fnp-3806	2447	4	,	,	PUNCT
fnp-3806	2447	5	li	li	PROPN
fnp-3806	2447	6	w	w	PROPN
fnp-3806	2447	7	,	,	PUNCT
fnp-3806	2447	8	benedetti	benedetti	PROPN
fnp-3806	2447	9	nj	nj	PROPN
fnp-3806	2447	10	,	,	PUNCT
fnp-3806	2447	11	et	et	PROPN
fnp-3806	2447	12	al	al	PROPN
fnp-3806	2447	13	.	.	PROPN
fnp-3806	2447	14	alpha	alpha	PROPN
fnp-3806	2447	15	7	7	NUM
fnp-3806	2447	16	nicotinic	nicotinic	ADJ
fnp-3806	2447	17	acetylcholine	acetylcholine	NOUN
fnp-3806	2447	18	receptors	receptor	NOUN
fnp-3806	2447	19	mediate	mediate	VERB
fnp-3806	2447	20	beta	beta	NOUN
fnp-3806	2447	21	-	-	PUNCT
fnp-3806	2447	22	amyloid	amyloid	NOUN
fnp-3806	2447	23	peptide	peptide	NOUN
fnp-3806	2447	24	-	-	PUNCT
fnp-3806	2447	25	induced	induce	VERB
fnp-3806	2447	26	tau	tau	PROPN
fnp-3806	2447	27	protein	protein	NOUN
fnp-3806	2447	28	phosphorylation	phosphorylation	NOUN
fnp-3806	2447	29	.	.	PUNCT
fnp-3806	2448	1	j	j	PROPN
fnp-3806	2448	2	biol	biol	PROPN
fnp-3806	2448	3	chem	chem	NOUN
fnp-3806	2448	4	2003	2003	NUM
fnp-3806	2448	5	;	;	PUNCT
fnp-3806	2448	6	278:31547	278:31547	NUM
fnp-3806	2448	7	-	-	SYM
fnp-3806	2448	8	31553	31553	NUM
fnp-3806	2448	9	.	.	PUNCT
fnp-3806	2449	1	https://doi.org/10.1074/jbc.m212532200	https://doi.org/10.1074/jbc.m212532200	X
fnp-3806	2449	2	shytle	shytle	PROPN
fnp-3806	2449	3	rd	rd	PROPN
fnp-3806	2449	4	,	,	PUNCT
fnp-3806	2449	5	mori	mori	PROPN
fnp-3806	2449	6	t	t	PROPN
fnp-3806	2449	7	,	,	PUNCT
fnp-3806	2449	8	townsend	townsend	PROPN
fnp-3806	2449	9	k	k	PROPN
fnp-3806	2449	10	,	,	PUNCT
fnp-3806	2449	11	et	et	PROPN
fnp-3806	2449	12	al	al	PROPN
fnp-3806	2449	13	.	.	PUNCT
fnp-3806	2449	14	cholinergic	cholinergic	ADJ
fnp-3806	2449	15	modulation	modulation	NOUN
fnp-3806	2449	16	of	of	ADP
fnp-3806	2449	17	microglial	microglial	ADJ
fnp-3806	2449	18	activation	activation	NOUN
fnp-3806	2449	19	by	by	ADP
fnp-3806	2449	20	alpha	alpha	NOUN
fnp-3806	2449	21	7	7	NUM
fnp-3806	2449	22	nicotinic	nicotinic	ADJ
fnp-3806	2449	23	receptors	receptor	NOUN
fnp-3806	2449	24	.	.	PUNCT
fnp-3806	2450	1	j	j	PROPN
fnp-3806	2450	2	neurochem	neurochem	PROPN
fnp-3806	2450	3	2004	2004	NUM
fnp-3806	2450	4	;	;	PUNCT
fnp-3806	2450	5	89:337	89:337	NUM
fnp-3806	2450	6	-	-	SYM
fnp-3806	2450	7	343	343	NUM
fnp-3806	2450	8	.	.	PUNCT
fnp-3806	2451	1	https://doi.org/10.1046/j.1471-4159.2004.02347.x	https://doi.org/10.1046/j.1471-4159.2004.02347.x	AUX
fnp-3806	2451	2	sadigh	sadigh	ADJ
fnp-3806	2451	3	-	-	PUNCT
fnp-3806	2451	4	eteghad	eteghad	NOUN
fnp-3806	2451	5	s	s	PROPN
fnp-3806	2451	6	,	,	PUNCT
fnp-3806	2451	7	majdi	majdi	NOUN
fnp-3806	2451	8	a	a	PRON
fnp-3806	2451	9	,	,	PUNCT
fnp-3806	2451	10	mahmoudi	mahmoudi	ADJ
fnp-3806	2451	11	j	j	PROPN
fnp-3806	2451	12	,	,	PUNCT
fnp-3806	2451	13	et	et	PROPN
fnp-3806	2451	14	al	al	PROPN
fnp-3806	2451	15	.	.	PROPN
fnp-3806	2452	1	astrocytic	astrocytic	ADJ
fnp-3806	2452	2	and	and	CCONJ
fnp-3806	2452	3	microglial	microglial	ADJ
fnp-3806	2452	4	nicotinic	nicotinic	ADJ
fnp-3806	2452	5	acetylcholine	acetylcholine	NOUN
fnp-3806	2452	6	receptors	receptor	NOUN
fnp-3806	2452	7	:	:	PUNCT
fnp-3806	2452	8	an	an	DET
fnp-3806	2452	9	overlooked	overlook	VERB
fnp-3806	2452	10	issue	issue	NOUN
fnp-3806	2452	11	in	in	ADP
fnp-3806	2452	12	alzheimer	alzheimer	PROPN
fnp-3806	2452	13	's	's	PART
fnp-3806	2452	14	disease	disease	NOUN
fnp-3806	2452	15	.	.	PUNCT
fnp-3806	2453	1	j	j	PROPN
fnp-3806	2453	2	neural	neural	PROPN
fnp-3806	2453	3	transm	transm	PROPN
fnp-3806	2453	4	2016;1231359	2016;1231359	NUM
fnp-3806	2453	5	-	-	SYM
fnp-3806	2453	6	1367	1367	NUM
fnp-3806	2453	7	.	.	PUNCT
fnp-3806	2454	1	https://doi.org/10.1007/s00702-016-1580-z	https://doi.org/10.1007/s00702-016-1580-z	PROPN
fnp-3806	2454	2	lebois	lebois	PROPN
fnp-3806	2454	3	ep	ep	PROPN
fnp-3806	2454	4	,	,	PUNCT
fnp-3806	2454	5	thorn	thorn	NOUN
fnp-3806	2454	6	c	c	PROPN
fnp-3806	2454	7	,	,	PUNCT
fnp-3806	2454	8	edgerton	edgerton	PROPN
fnp-3806	2454	9	jr	jr	PROPN
fnp-3806	2454	10	,	,	PUNCT
fnp-3806	2454	11	et	et	PROPN
fnp-3806	2454	12	al	al	PROPN
fnp-3806	2454	13	.	.	PROPN
fnp-3806	2454	14	muscarinic	muscarinic	ADJ
fnp-3806	2454	15	receptor	receptor	NOUN
fnp-3806	2454	16	subtype	subtype	NOUN
fnp-3806	2454	17	distribution	distribution	NOUN
fnp-3806	2454	18	in	in	ADP
fnp-3806	2454	19	the	the	DET
fnp-3806	2454	20	central	central	ADJ
fnp-3806	2454	21	nervous	nervous	ADJ
fnp-3806	2454	22	system	system	NOUN
fnp-3806	2454	23	and	and	CCONJ
fnp-3806	2454	24	relevance	relevance	NOUN
fnp-3806	2454	25	to	to	ADP
fnp-3806	2454	26	aging	aging	NOUN
fnp-3806	2454	27	and	and	CCONJ
fnp-3806	2454	28	alzheimer	alzheimer	PROPN
fnp-3806	2454	29	’s	’s	PART
fnp-3806	2454	30	disease	disease	NOUN
fnp-3806	2454	31	.	.	PUNCT
fnp-3806	2455	1	neuropharmacology	neuropharmacology	NOUN
fnp-3806	2455	2	2018	2018	NUM
fnp-3806	2455	3	;	;	PUNCT
fnp-3806	2455	4	136	136	NUM
fnp-3806	2455	5	:	:	PUNCT
fnp-3806	2455	6	362	362	NUM
fnp-3806	2455	7	-	-	SYM
fnp-3806	2455	8	373	373	NUM
fnp-3806	2455	9	.	.	PUNCT
fnp-3806	2456	1	https://doi.org/10.1016/j.neuropharm.2017.11.018	https://doi.org/10.1016/j.neuropharm.2017.11.018	NOUN
fnp-3806	2456	2	volpicelli	volpicelli	PROPN
fnp-3806	2456	3	la	la	PROPN
fnp-3806	2456	4	,	,	PUNCT
fnp-3806	2456	5	allan	allan	PROPN
fnp-3806	2456	6	il	il	PROPN
fnp-3806	2456	7	.	.	PROPN
fnp-3806	2456	8	muscarinic	muscarinic	ADJ
fnp-3806	2456	9	acetylcholine	acetylcholine	NOUN
fnp-3806	2456	10	receptor	receptor	NOUN
fnp-3806	2456	11	subtypes	subtype	NOUN
fnp-3806	2456	12	in	in	ADP
fnp-3806	2456	13	cerebral	cerebral	ADJ
fnp-3806	2456	14	cortex	cortex	NOUN
fnp-3806	2456	15	and	and	CCONJ
fnp-3806	2456	16	hippocampus	hippocampus	PROPN
fnp-3806	2456	17	.	.	PUNCT
fnp-3806	2457	1	prog	prog	NOUN
fnp-3806	2457	2	brain	brain	NOUN
fnp-3806	2457	3	res	re	NOUN
fnp-3806	2457	4	2004;145:59	2004;145:59	NUM
fnp-3806	2457	5	-	-	SYM
fnp-3806	2457	6	66	66	NUM
fnp-3806	2457	7	.	.	PUNCT
fnp-3806	2458	1	https://doi.org/10.1016/s0079-6123(03)45003-6	https://doi.org/10.1016/s0079-6123(03)45003-6	PROPN
fnp-3806	2458	2	ishii	ishii	PROPN
fnp-3806	2458	3	m	m	PROPN
fnp-3806	2458	4	,	,	PUNCT
fnp-3806	2458	5	kurachi	kurachi	PROPN
fnp-3806	2458	6	y.	y.	PROPN
fnp-3806	2458	7	muscarinic	muscarinic	ADJ
fnp-3806	2458	8	acetylcholine	acetylcholine	NOUN
fnp-3806	2458	9	receptors	receptor	NOUN
fnp-3806	2458	10	.	.	PUNCT
fnp-3806	2459	1	curr	curr	PROPN
fnp-3806	2459	2	pharm	pharm	PROPN
fnp-3806	2459	3	des	des	PROPN
fnp-3806	2459	4	2006;12	2006;12	NUM
fnp-3806	2459	5	:	:	PUNCT
fnp-3806	2459	6	3573	3573	NUM
fnp-3806	2459	7	-	-	SYM
fnp-3806	2459	8	3581	3581	NUM
fnp-3806	2459	9	.	.	PUNCT
fnp-3806	2460	1	https://doi.org/10.2174/138161206778522056	https://doi.org/10.2174/138161206778522056	PROPN
fnp-3806	2460	2	kudlak	kudlak	PROPN
fnp-3806	2460	3	m	m	PROPN
fnp-3806	2460	4	,	,	PUNCT
fnp-3806	2460	5	tadi	tadi	ADJ
fnp-3806	2460	6	p.	p.	NOUN
fnp-3806	2460	7	physiology	physiology	NOUN
fnp-3806	2460	8	,	,	PUNCT
fnp-3806	2460	9	muscarinic	muscarinic	ADJ
fnp-3806	2460	10	receptor	receptor	NOUN
fnp-3806	2460	11	.	.	PUNCT
fnp-3806	2461	1	in	in	ADP
fnp-3806	2461	2	statpearls	statpearl	NOUN
fnp-3806	2461	3	;	;	PUNCT
fnp-3806	2461	4	statpearls	statpearl	NOUN
fnp-3806	2461	5	publishing	publishing	NOUN
fnp-3806	2461	6	:	:	PUNCT
fnp-3806	2461	7	treasure	treasure	NOUN
fnp-3806	2461	8	island	island	NOUN
fnp-3806	2461	9	,	,	PUNCT
fnp-3806	2461	10	fl	fl	PROPN
fnp-3806	2461	11	,	,	PUNCT
fnp-3806	2461	12	usa	usa	PROPN
fnp-3806	2461	13	,	,	PUNCT
fnp-3806	2461	14	2021	2021	NUM
fnp-3806	2461	15	.	.	PUNCT
fnp-3806	2462	1	pavía	pavía	PROPN
fnp-3806	2462	2	j	j	PROPN
fnp-3806	2462	3	,	,	PUNCT
fnp-3806	2462	4	de	de	PROPN
fnp-3806	2462	5	ceballos	ceballos	PROPN
fnp-3806	2462	6	ml	ml	PROPN
fnp-3806	2462	7	,	,	PUNCT
fnp-3806	2462	8	sanchez	sanchez	PROPN
fnp-3806	2462	9	de	de	PROPN
fnp-3806	2462	10	la	la	PROPN
fnp-3806	2462	11	cuesta	cuesta	PROPN
fnp-3806	2462	12	f.	f.	PROPN
fnp-3806	2462	13	alzheimer	alzheimer	PROPN
fnp-3806	2462	14	's	's	PART
fnp-3806	2462	15	disease	disease	NOUN
fnp-3806	2462	16	:	:	PUNCT
fnp-3806	2462	17	relationship	relationship	NOUN
fnp-3806	2462	18	between	between	ADP
fnp-3806	2462	19	muscarinic	muscarinic	ADJ
fnp-3806	2462	20	cholinergic	cholinergic	ADJ
fnp-3806	2462	21	receptors	receptor	NOUN
fnp-3806	2462	22	,	,	PUNCT
fnp-3806	2462	23	beta	beta	NOUN
fnp-3806	2462	24	-	-	PUNCT
fnp-3806	2462	25	amyloid	amyloid	NOUN
fnp-3806	2462	26	and	and	CCONJ
fnp-3806	2462	27	tau	tau	PROPN
fnp-3806	2462	28	proteins	protein	NOUN
fnp-3806	2462	29	.	.	PUNCT
fnp-3806	2463	1	fundam	fundam	PROPN
fnp-3806	2463	2	clin	clin	PROPN
fnp-3806	2463	3	pharmacol	pharmacol	PROPN
fnp-3806	2463	4	1998;12:473	1998;12:473	PROPN
fnp-3806	2463	5	-	-	SYM
fnp-3806	2463	6	481	481	NUM
fnp-3806	2463	7	.	.	PUNCT
fnp-3806	2464	1	https://doi.org/10.1111/j.1472-8206.1998.tb00975.x	https://doi.org/10.1111/j.1472-8206.1998.tb00975.x	PROPN
fnp-3806	2464	2	clader	clader	NOUN
fnp-3806	2464	3	jw	jw	PROPN
fnp-3806	2464	4	,	,	PUNCT
fnp-3806	2464	5	wang	wang	PROPN
fnp-3806	2464	6	y.	y.	PROPN
fnp-3806	2464	7	muscarinic	muscarinic	ADJ
fnp-3806	2464	8	receptor	receptor	NOUN
fnp-3806	2464	9	agonists	agonist	NOUN
fnp-3806	2464	10	and	and	CCONJ
fnp-3806	2464	11	antagonists	antagonist	NOUN
fnp-3806	2464	12	in	in	ADP
fnp-3806	2464	13	the	the	DET
fnp-3806	2464	14	treatment	treatment	NOUN
fnp-3806	2464	15	of	of	ADP
fnp-3806	2464	16	alzheimer	alzheimer	PROPN
fnp-3806	2464	17	’s	’s	PART
fnp-3806	2464	18	disease	disease	NOUN
fnp-3806	2464	19	.	.	PUNCT
fnp-3806	2465	1	curr	curr	PROPN
fnp-3806	2465	2	pharm	pharm	PROPN
fnp-3806	2465	3	des	des	PROPN
fnp-3806	2465	4	2005;11:3353	2005;11:3353	PROPN
fnp-3806	2465	5	-	-	SYM
fnp-3806	2465	6	3361	3361	NUM
fnp-3806	2465	7	.	.	PUNCT
fnp-3806	2466	1	https://doi.org/10.2174/138161205774370762	https://doi.org/10.2174/138161205774370762	NOUN
fnp-3806	2467	1	fisher	fisher	PROPN
fnp-3806	2467	2	a.	a.	PROPN
fnp-3806	2467	3	cholinergic	cholinergic	PROPN
fnp-3806	2467	4	treatments	treatment	NOUN
fnp-3806	2467	5	with	with	ADP
fnp-3806	2467	6	emphasis	emphasis	NOUN
fnp-3806	2467	7	on	on	ADP
fnp-3806	2467	8	m1	m1	NOUN
fnp-3806	2467	9	muscarinic	muscarinic	NOUN
fnp-3806	2467	10	agonists	agonist	NOUN
fnp-3806	2467	11	as	as	ADP
fnp-3806	2467	12	potential	potential	ADJ
fnp-3806	2467	13	disease	disease	NOUN
fnp-3806	2467	14	-	-	PUNCT
fnp-3806	2467	15	modifying	modify	VERB
fnp-3806	2467	16	agents	agent	NOUN
fnp-3806	2467	17	for	for	ADP
fnp-3806	2467	18	alzheimer	alzheimer	PROPN
fnp-3806	2467	19	’s	’s	PART
fnp-3806	2467	20	disease	disease	NOUN
fnp-3806	2467	21	.	.	PUNCT
fnp-3806	2468	1	neurotherapeutics	neurotherapeutics	PROPN
fnp-3806	2468	2	2008	2008	NUM
fnp-3806	2468	3	;	;	PUNCT
fnp-3806	2468	4	5:433	5:433	NUM
fnp-3806	2468	5	-	-	SYM
fnp-3806	2468	6	442	442	NUM
fnp-3806	2468	7	.	.	PUNCT
fnp-3806	2469	1	https://doi.org/10.1016/j.nurt.2008.05.002	https://doi.org/10.1016/j.nurt.2008.05.002	NOUN
fnp-3806	2469	2	davis	davis	PROPN
fnp-3806	2469	3	aa	aa	PROPN
fnp-3806	2469	4	,	,	PUNCT
fnp-3806	2469	5	fritz	fritz	PROPN
fnp-3806	2469	6	jj	jj	PROPN
fnp-3806	2469	7	,	,	PUNCT
fnp-3806	2469	8	wess	wess	PROPN
fnp-3806	2469	9	j	j	PROPN
fnp-3806	2469	10	,	,	PUNCT
fnp-3806	2469	11	et	et	PROPN
fnp-3806	2469	12	al	al	PROPN
fnp-3806	2469	13	.	.	PROPN
fnp-3806	2469	14	deletion	deletion	NOUN
fnp-3806	2469	15	of	of	ADP
fnp-3806	2469	16	m1	m1	PROPN
fnp-3806	2469	17	muscarinic	muscarinic	ADJ
fnp-3806	2469	18	acetylcholine	acetylcholine	NOUN
fnp-3806	2469	19	receptors	receptor	NOUN
fnp-3806	2469	20	increases	increase	VERB
fnp-3806	2469	21	amyloid	amyloid	NOUN
fnp-3806	2469	22	pathology	pathology	NOUN
fnp-3806	2469	23	in	in	ADP
fnp-3806	2469	24	vitro	vitro	X
fnp-3806	2469	25	and	and	CCONJ
fnp-3806	2469	26	in	in	ADP
fnp-3806	2469	27	vivo	vivo	NOUN
fnp-3806	2469	28	.	.	PUNCT
fnp-3806	2470	1	j	j	PROPN
fnp-3806	2470	2	neurosci	neurosci	PROPN
fnp-3806	2470	3	2010;30:4190	2010;30:4190	NUM
fnp-3806	2470	4	-	-	PUNCT
fnp-3806	2470	5	4196	4196	NUM
fnp-3806	2470	6	.	.	PUNCT
fnp-3806	2471	1	https://doi.org/10.1523/jneurosci.6393-09.2010	https://doi.org/10.1523/jneurosci.6393-09.2010	NOUN
fnp-3806	2471	2	geula	geula	PROPN
fnp-3806	2471	3	c	c	PROPN
fnp-3806	2471	4	,	,	PUNCT
fnp-3806	2471	5	mesulam	mesulam	PROPN
fnp-3806	2471	6	m.	m.	NOUN
fnp-3806	2471	7	special	special	ADJ
fnp-3806	2471	8	properties	property	NOUN
fnp-3806	2471	9	of	of	ADP
fnp-3806	2471	10	cholinesterases	cholinesterase	NOUN
fnp-3806	2471	11	in	in	ADP
fnp-3806	2471	12	the	the	DET
fnp-3806	2471	13	cerebral	cerebral	ADJ
fnp-3806	2471	14	cortex	cortex	NOUN
fnp-3806	2471	15	of	of	ADP
fnp-3806	2471	16	alzheimer	alzheimer	PROPN
fnp-3806	2471	17	’s	’s	PART
fnp-3806	2471	18	disease	disease	NOUN
fnp-3806	2471	19	.	.	PUNCT
fnp-3806	2472	1	brain	brain	NOUN
fnp-3806	2472	2	res	re	NOUN
fnp-3806	2472	3	1989;498	1989;498	NUM
fnp-3806	2472	4	:	:	PUNCT
fnp-3806	2472	5	185	185	NUM
fnp-3806	2472	6	-	-	SYM
fnp-3806	2472	7	189	189	NUM
fnp-3806	2472	8	.	.	PUNCT
fnp-3806	2473	1	https://doi.org/10.1016/0006-8993(89)90419-8	https://doi.org/10.1016/0006-8993(89)90419-8	PROPN
fnp-3806	2473	2	sberna	sberna	VERB
fnp-3806	2473	3	g	g	PROPN
fnp-3806	2473	4	,	,	PUNCT
fnp-3806	2473	5	sáez	sáez	PROPN
fnp-3806	2473	6	-	-	PUNCT
fnp-3806	2473	7	valero	valero	PROPN
fnp-3806	2473	8	j	j	PROPN
fnp-3806	2473	9	,	,	PUNCT
fnp-3806	2473	10	beyreuther	beyreuther	PROPN
fnp-3806	2473	11	k	k	PROPN
fnp-3806	2473	12	,	,	PUNCT
fnp-3806	2473	13	et	et	PROPN
fnp-3806	2473	14	al	al	PROPN
fnp-3806	2473	15	.	.	PUNCT
fnp-3806	2474	1	the	the	DET
fnp-3806	2474	2	amyloid	amyloid	NOUN
fnp-3806	2474	3	beta	beta	NOUN
fnp-3806	2474	4	-	-	PUNCT
fnp-3806	2474	5	protein	protein	NOUN
fnp-3806	2474	6	of	of	ADP
fnp-3806	2474	7	alzheimer	alzheimer	PROPN
fnp-3806	2474	8	’s	’s	PART
fnp-3806	2474	9	disease	disease	NOUN
fnp-3806	2474	10	increases	increase	VERB
fnp-3806	2474	11	acetylcholinesterase	acetylcholinesterase	NOUN
fnp-3806	2474	12	expression	expression	NOUN
fnp-3806	2474	13	by	by	ADP
fnp-3806	2474	14	increasing	increase	VERB
fnp-3806	2474	15	intracellular	intracellular	ADJ
fnp-3806	2474	16	calcium	calcium	NOUN
fnp-3806	2474	17	in	in	ADP
fnp-3806	2474	18	embryonal	embryonal	ADJ
fnp-3806	2474	19	carcinoma	carcinoma	NOUN
fnp-3806	2474	20	p19	p19	NOUN
fnp-3806	2474	21	cells	cell	NOUN
fnp-3806	2474	22	.	.	PUNCT
fnp-3806	2475	1	j	j	PROPN
fnp-3806	2475	2	neurochem	neurochem	PROPN
fnp-3806	2475	3	1997;69:1177	1997;69:1177	NUM
fnp-3806	2475	4	-	-	SYM
fnp-3806	2475	5	1184	1184	NUM
fnp-3806	2475	6	.	.	PUNCT
fnp-3806	2476	1	https://doi.org/10.1046/j.1471-4159.1997.69031177.x	https://doi.org/10.1046/j.1471-4159.1997.69031177.x	NOUN
fnp-3806	2476	2	furukawa	furukawa	PROPN
fnp-3806	2476	3	h	h	PROPN
fnp-3806	2476	4	,	,	PUNCT
fnp-3806	2476	5	singh	singh	PROPN
fnp-3806	2476	6	sk	sk	NOUN
fnp-3806	2476	7	,	,	PUNCT
fnp-3806	2476	8	mancusso	mancusso	NOUN
fnp-3806	2476	9	r	r	NOUN
fnp-3806	2476	10	,	,	PUNCT
fnp-3806	2476	11	et	et	PROPN
fnp-3806	2476	12	al	al	PROPN
fnp-3806	2476	13	.	.	PROPN
fnp-3806	2476	14	subunit	subunit	NOUN
fnp-3806	2476	15	arrangement	arrangement	NOUN
fnp-3806	2476	16	and	and	CCONJ
fnp-3806	2476	17	function	function	NOUN
fnp-3806	2476	18	in	in	ADP
fnp-3806	2476	19	nmda	nmda	ADJ
fnp-3806	2476	20	receptors	receptor	NOUN
fnp-3806	2476	21	.	.	PUNCT
fnp-3806	2477	1	nature	nature	NOUN
fnp-3806	2477	2	2005;438:185	2005;438:185	NUM
fnp-3806	2477	3	-	-	SYM
fnp-3806	2477	4	192	192	NUM
fnp-3806	2477	5	.	.	PUNCT
fnp-3806	2478	1	https://doi.org/10.1038/nature04089	https://doi.org/10.1038/nature04089	PROPN
fnp-3806	2478	2	yamamoto	yamamoto	PROPN
fnp-3806	2478	3	h	h	PROPN
fnp-3806	2478	4	,	,	PUNCT
fnp-3806	2478	5	hagino	hagino	PROPN
fnp-3806	2478	6	y	y	PROPN
fnp-3806	2478	7	,	,	PUNCT
fnp-3806	2478	8	kasai	kasai	PROPN
fnp-3806	2478	9	s	s	PROPN
fnp-3806	2478	10	,	,	PUNCT
fnp-3806	2478	11	et	et	PROPN
fnp-3806	2478	12	al	al	PROPN
fnp-3806	2478	13	.	.	PUNCT
fnp-3806	2478	14	specific	specific	ADJ
fnp-3806	2478	15	roles	role	NOUN
fnp-3806	2478	16	of	of	ADP
fnp-3806	2478	17	nmda	nmda	ADJ
fnp-3806	2478	18	receptor	receptor	NOUN
fnp-3806	2478	19	subunits	subunit	NOUN
fnp-3806	2478	20	in	in	ADP
fnp-3806	2478	21	mental	mental	ADJ
fnp-3806	2478	22	disorders	disorder	NOUN
fnp-3806	2478	23	.	.	PUNCT
fnp-3806	2479	1	curr	curr	PROPN
fnp-3806	2479	2	mol	mol	ADP
fnp-3806	2479	3	med	med	PROPN
fnp-3806	2479	4	2015	2015	NUM
fnp-3806	2479	5	;	;	PUNCT
fnp-3806	2479	6	15	15	NUM
fnp-3806	2479	7	:	:	SYM
fnp-3806	2479	8	193	193	NUM
fnp-3806	2479	9	-	-	SYM
fnp-3806	2479	10	205	205	NUM
fnp-3806	2479	11	.	.	PUNCT
fnp-3806	2480	1	https://doi.org/10.2174/1566524015666150330142807	https://doi.org/10.2174/1566524015666150330142807	VERB
fnp-3806	2480	2	pinheiro	pinheiro	PROPN
fnp-3806	2480	3	ps	ps	PROPN
fnp-3806	2480	4	,	,	PUNCT
fnp-3806	2480	5	mulle	mulle	PROPN
fnp-3806	2480	6	c.	c.	PROPN
fnp-3806	2480	7	presynaptic	presynaptic	ADJ
fnp-3806	2480	8	glutamate	glutamate	NOUN
fnp-3806	2480	9	receptors	receptor	NOUN
fnp-3806	2480	10	:	:	PUNCT
fnp-3806	2480	11	physiological	physiological	ADJ
fnp-3806	2480	12	functions	function	NOUN
fnp-3806	2480	13	and	and	CCONJ
fnp-3806	2480	14	mechanisms	mechanism	NOUN
fnp-3806	2480	15	of	of	ADP
fnp-3806	2480	16	action	action	NOUN
fnp-3806	2480	17	.	.	PUNCT
fnp-3806	2481	1	nature	nature	PROPN
fnp-3806	2481	2	rev	rev	VERB
fnp-3806	2481	3	neurosci	neurosci	PROPN
fnp-3806	2481	4	2008	2008	NUM
fnp-3806	2481	5	;	;	PUNCT
fnp-3806	2482	1	9:423	9:423	NUM
fnp-3806	2482	2	.	.	PUNCT
fnp-3806	2482	3	https://doi.org/10.1038/nrn2379	https://doi.org/10.1038/nrn2379	PROPN
fnp-3806	2482	4	steinhäuser	steinhäuser	PROPN
fnp-3806	2482	5	c	c	PROPN
fnp-3806	2482	6	,	,	PUNCT
fnp-3806	2482	7	gallo	gallo	PROPN
fnp-3806	2482	8	v.	v.	ADP
fnp-3806	2482	9	news	news	NOUN
fnp-3806	2482	10	on	on	ADP
fnp-3806	2482	11	glutamate	glutamate	ADJ
fnp-3806	2482	12	receptors	receptor	NOUN
fnp-3806	2482	13	in	in	ADP
fnp-3806	2482	14	glial	glial	ADJ
fnp-3806	2482	15	cells	cell	NOUN
fnp-3806	2482	16	.	.	PUNCT
fnp-3806	2483	1	trends	trend	NOUN
fnp-3806	2483	2	neurosci	neurosci	VERB
fnp-3806	2483	3	1996;19	1996;19	NUM
fnp-3806	2483	4	:	:	PUNCT
fnp-3806	2483	5	339	339	NUM
fnp-3806	2483	6	-	-	SYM
fnp-3806	2483	7	345	345	NUM
fnp-3806	2483	8	.	.	PUNCT
fnp-3806	2484	1	https://doi.org/10.1016/0166-2236(96)10043-6	https://doi.org/10.1016/0166-2236(96)10043-6	PROPN
fnp-3806	2485	1	shemer	shemer	NOUN
fnp-3806	2485	2	i	i	PROPN
fnp-3806	2485	3	,	,	PUNCT
fnp-3806	2485	4	holmgren	holmgren	PROPN
fnp-3806	2485	5	c	c	PROPN
fnp-3806	2485	6	,	,	PUNCT
fnp-3806	2485	7	min	min	PROPN
fnp-3806	2485	8	r	r	NOUN
fnp-3806	2485	9	,	,	PUNCT
fnp-3806	2485	10	et	et	PROPN
fnp-3806	2485	11	al	al	PROPN
fnp-3806	2485	12	.	.	PUNCT
fnp-3806	2486	1	non	non	ADJ
fnp-3806	2486	2	-	-	ADJ
fnp-3806	2486	3	fibrillar	fibrillar	ADJ
fnp-3806	2486	4	beta	beta	NOUN
fnp-3806	2486	5	-	-	PUNCT
fnp-3806	2486	6	amyloid	amyloid	NOUN
fnp-3806	2486	7	abates	abate	VERB
fnp-3806	2486	8	spike	spike	ADJ
fnp-3806	2486	9	-	-	PUNCT
fnp-3806	2486	10	timing	timing	NOUN
fnp-3806	2486	11	-	-	PUNCT
fnp-3806	2486	12	dependent	dependent	ADJ
fnp-3806	2486	13	synaptic	synaptic	ADJ
fnp-3806	2486	14	potentiation	potentiation	NOUN
fnp-3806	2486	15	at	at	ADP
fnp-3806	2486	16	excitatory	excitatory	ADJ
fnp-3806	2486	17	synapses	synapsis	NOUN
fnp-3806	2486	18	in	in	ADP
fnp-3806	2486	19	layer	layer	NOUN
fnp-3806	2486	20	2/3	2/3	NUM
fnp-3806	2486	21	of	of	ADP
fnp-3806	2486	22	the	the	DET
fnp-3806	2486	23	neocortex	neocortex	NOUN
fnp-3806	2486	24	by	by	ADP
fnp-3806	2486	25	targeting	target	VERB
fnp-3806	2486	26	postsynaptic	postsynaptic	ADJ
fnp-3806	2486	27	ampa	ampa	NOUN
fnp-3806	2486	28	receptors	receptor	NOUN
fnp-3806	2486	29	.	.	PUNCT
fnp-3806	2487	1	eur	eur	PROPN
fnp-3806	2487	2	j	j	PROPN
fnp-3806	2487	3	neurosci	neurosci	PROPN
fnp-3806	2487	4	2006;23:2035	2006;23:2035	PROPN
fnp-3806	2487	5	-	-	SYM
fnp-3806	2487	6	47	47	NUM
fnp-3806	2487	7	.	.	PUNCT
fnp-3806	2488	1	https://doi.org/10.1111/j.1460-9568.2006.04733.x	https://doi.org/10.1111/j.1460-9568.2006.04733.x	PROPN
fnp-3806	2488	2	parameshwaran	parameshwaran	VERB
fnp-3806	2488	3	k	k	PROPN
fnp-3806	2488	4	,	,	PUNCT
fnp-3806	2488	5	dhanasekaran	dhanasekaran	PROPN
fnp-3806	2488	6	m	m	PROPN
fnp-3806	2488	7	,	,	PUNCT
fnp-3806	2488	8	suppiramaniam	suppiramaniam	ADJ
fnp-3806	2488	9	v.	v.	ADP
fnp-3806	2488	10	amyloid	amyloid	NOUN
fnp-3806	2488	11	beta	beta	NOUN
fnp-3806	2488	12	peptides	peptide	NOUN
fnp-3806	2488	13	and	and	CCONJ
fnp-3806	2488	14	glutamatergic	glutamatergic	ADJ
fnp-3806	2488	15	synaptic	synaptic	ADJ
fnp-3806	2488	16	dysregulation	dysregulation	NOUN
fnp-3806	2488	17	.	.	PUNCT
fnp-3806	2489	1	exp	exp	NOUN
fnp-3806	2489	2	neurol	neurol	NOUN
fnp-3806	2489	3	2008;210:7	2008;210:7	PROPN
fnp-3806	2489	4	-	-	SYM
fnp-3806	2489	5	13	13	NUM
fnp-3806	2489	6	.	.	PUNCT
fnp-3806	2490	1	https://doi.org/10.1016/j.expneurol.2007.10.008	https://doi.org/10.1016/j.expneurol.2007.10.008	PROPN
fnp-3806	2490	2	ferreira	ferreira	PROPN
fnp-3806	2490	3	il	il	PROPN
fnp-3806	2490	4	,	,	PUNCT
fnp-3806	2490	5	bajouco	bajouco	PROPN
fnp-3806	2490	6	lm	lm	PROPN
fnp-3806	2490	7	,	,	PUNCT
fnp-3806	2490	8	mota	mota	PROPN
fnp-3806	2490	9	si	si	X
fnp-3806	2490	10	,	,	PUNCT
fnp-3806	2490	11	et	et	PROPN
fnp-3806	2490	12	al	al	PROPN
fnp-3806	2490	13	.	.	PUNCT
fnp-3806	2490	14	amyloid	amyloid	PROPN
fnp-3806	2491	1	beta	beta	ADJ
fnp-3806	2491	2	peptide	peptide	NOUN
fnp-3806	2491	3	1	1	NUM
fnp-3806	2491	4	-	-	SYM
fnp-3806	2491	5	42	42	NUM
fnp-3806	2491	6	disturbs	disturb	VERB
fnp-3806	2491	7	intracellular	intracellular	ADJ
fnp-3806	2491	8	calcium	calcium	NOUN
fnp-3806	2491	9	homeostasis	homeostasis	NOUN
fnp-3806	2491	10	through	through	ADP
fnp-3806	2491	11	activation	activation	NOUN
fnp-3806	2491	12	of	of	ADP
fnp-3806	2491	13	glun2b	glun2b	NOUN
fnp-3806	2491	14	-	-	PUNCT
fnp-3806	2491	15	containing	contain	VERB
fnp-3806	2491	16	n	n	CCONJ
fnp-3806	2491	17	-	-	PUNCT
fnp-3806	2491	18	methyl	methyl	NOUN
fnp-3806	2491	19	-	-	PUNCT
fnp-3806	2491	20	d	d	NOUN
fnp-3806	2491	21	-	-	PUNCT
fnp-3806	2491	22	aspartate	aspartate	ADJ
fnp-3806	2491	23	receptors	receptor	NOUN
fnp-3806	2491	24	in	in	ADP
fnp-3806	2491	25	cortical	cortical	ADJ
fnp-3806	2491	26	cultures	culture	NOUN
fnp-3806	2491	27	.	.	PUNCT
fnp-3806	2492	1	cell	cell	NOUN
fnp-3806	2492	2	calcium	calcium	NOUN
fnp-3806	2492	3	2012;51:95	2012;51:95	NUM
fnp-3806	2492	4	-	-	SYM
fnp-3806	2492	5	106	106	NUM
fnp-3806	2492	6	.	.	PUNCT
fnp-3806	2493	1	https://doi.org/10.1016/j.ceca.2011.11.008	https://doi.org/10.1016/j.ceca.2011.11.008	NOUN
fnp-3806	2493	2	decker	decker	PROPN
fnp-3806	2493	3	h	h	PROPN
fnp-3806	2493	4	,	,	PUNCT
fnp-3806	2493	5	jürgensen	jürgensen	PROPN
fnp-3806	2493	6	s	s	PROPN
fnp-3806	2493	7	,	,	PUNCT
fnp-3806	2493	8	adrover	adrover	NOUN
fnp-3806	2493	9	mf	mf	VERB
fnp-3806	2493	10	,	,	PUNCT
fnp-3806	2493	11	et	et	PROPN
fnp-3806	2493	12	al	al	PROPN
fnp-3806	2493	13	.	.	PROPN
fnp-3806	2493	14	n	n	CCONJ
fnp-3806	2493	15	-	-	PUNCT
fnp-3806	2493	16	methyl	methyl	NOUN
fnp-3806	2493	17	-	-	PUNCT
fnp-3806	2493	18	d	d	NOUN
fnp-3806	2493	19	-	-	PUNCT
fnp-3806	2493	20	aspartate	aspartate	ADJ
fnp-3806	2493	21	receptors	receptor	NOUN
fnp-3806	2493	22	are	be	AUX
fnp-3806	2493	23	required	require	VERB
fnp-3806	2493	24	for	for	ADP
fnp-3806	2493	25	synaptic	synaptic	ADJ
fnp-3806	2493	26	targeting	targeting	NOUN
fnp-3806	2493	27	of	of	ADP
fnp-3806	2493	28	alzheimer	alzheimer	PROPN
fnp-3806	2493	29	's	's	PART
fnp-3806	2493	30	toxic	toxic	ADJ
fnp-3806	2493	31	amyloid	amyloid	NOUN
fnp-3806	2493	32	-	-	PUNCT
fnp-3806	2493	33	β	β	X
fnp-3806	2493	34	peptide	peptide	NOUN
fnp-3806	2493	35	oligomers	oligomer	NOUN
fnp-3806	2493	36	.	.	PUNCT
fnp-3806	2494	1	j	j	PROPN
fnp-3806	2494	2	neurochem	neurochem	PROPN
fnp-3806	2494	3	2010;115:1520	2010;115:1520	NUM
fnp-3806	2494	4	-	-	PUNCT
fnp-3806	2494	5	1529	1529	NUM
fnp-3806	2494	6	.	.	PUNCT
fnp-3806	2495	1	https://doi.org/10.1111/j.1471-4159.2010.07058.x	https://doi.org/10.1111/j.1471-4159.2010.07058.x	ADJ
fnp-3806	2495	2	epub	epub	NOUN
fnp-3806	2495	3	2010	2010	NUM
fnp-3806	2495	4	nov	nov	NOUN
fnp-3806	2495	5	11	11	NUM
fnp-3806	2495	6	.	.	PUNCT
fnp-3806	2496	1	bordji	bordji	PROPN
fnp-3806	2496	2	k	k	NOUN
fnp-3806	2496	3	,	,	PUNCT
fnp-3806	2496	4	becerril	becerril	NOUN
fnp-3806	2496	5	-	-	PUNCT
fnp-3806	2496	6	ortega	ortega	PROPN
fnp-3806	2496	7	j	j	PROPN
fnp-3806	2496	8	,	,	PUNCT
fnp-3806	2496	9	buisson	buisson	PROPN
fnp-3806	2496	10	a.	a.	NOUN
fnp-3806	2496	11	synapses	synapses	PROPN
fnp-3806	2496	12	,	,	PUNCT
fnp-3806	2496	13	nmda	nmda	ADJ
fnp-3806	2496	14	receptor	receptor	NOUN
fnp-3806	2496	15	activity	activity	NOUN
fnp-3806	2496	16	and	and	CCONJ
fnp-3806	2496	17	neuronal	neuronal	ADJ
fnp-3806	2496	18	abeta	abeta	NOUN
fnp-3806	2496	19	production	production	NOUN
fnp-3806	2496	20	in	in	ADP
fnp-3806	2496	21	alzheimer	alzheimer	PROPN
fnp-3806	2496	22	's	's	PART
fnp-3806	2496	23	disease	disease	NOUN
fnp-3806	2496	24	.	.	PUNCT
fnp-3806	2497	1	rev	rev	PROPN
fnp-3806	2497	2	neurosci	neurosci	PROPN
fnp-3806	2497	3	2011;22:285	2011;22:285	PROPN
fnp-3806	2497	4	-	-	SYM
fnp-3806	2497	5	294	294	NUM
fnp-3806	2497	6	.	.	PUNCT
fnp-3806	2498	1	https://doi.org/10.1515/rns.2011.029	https://doi.org/10.1515/rns.2011.029	PROPN
fnp-3806	2498	2	mota	mota	PROPN
fnp-3806	2498	3	si	si	PROPN
fnp-3806	2498	4	,	,	PUNCT
fnp-3806	2498	5	ferreira	ferreira	PROPN
fnp-3806	2498	6	il	il	PROPN
fnp-3806	2498	7	,	,	PUNCT
fnp-3806	2498	8	rego	rego	PROPN
fnp-3806	2498	9	ac	ac	PROPN
fnp-3806	2498	10	.	.	PROPN
fnp-3806	2498	11	dysfunctional	dysfunctional	ADJ
fnp-3806	2498	12	synapse	synapse	NOUN
fnp-3806	2498	13	in	in	ADP
fnp-3806	2498	14	alzheimer	alzheimer	PROPN
fnp-3806	2498	15	's	's	PART
fnp-3806	2498	16	disease	disease	NOUN
fnp-3806	2498	17	a	a	DET
fnp-3806	2498	18	focus	focus	NOUN
fnp-3806	2498	19	on	on	ADP
fnp-3806	2498	20	nmda	nmda	ADJ
fnp-3806	2498	21	receptors	receptor	NOUN
fnp-3806	2498	22	.	.	PUNCT
fnp-3806	2499	1	neuropharmacology	neuropharmacology	NOUN
fnp-3806	2499	2	2014;76:16	2014;76:16	NUM
fnp-3806	2499	3	-	-	SYM
fnp-3806	2499	4	26	26	NUM
fnp-3806	2499	5	.	.	PUNCT
fnp-3806	2500	1	https://doi.org/10.1016/j.neuropharm.2013.08.013	https://doi.org/10.1016/j.neuropharm.2013.08.013	NUM
fnp-3806	2500	2	zhang	zhang	PROPN
fnp-3806	2500	3	y	y	PROPN
fnp-3806	2500	4	,	,	PUNCT
fnp-3806	2500	5	li	li	PROPN
fnp-3806	2500	6	p	p	PROPN
fnp-3806	2500	7	,	,	PUNCT
fnp-3806	2500	8	feng	feng	PROPN
fnp-3806	2500	9	j	j	PROPN
fnp-3806	2500	10	,	,	PUNCT
fnp-3806	2500	11	wu	wu	PROPN
fnp-3806	2500	12	m.	m.	NOUN
fnp-3806	2500	13	dysfunction	dysfunction	NOUN
fnp-3806	2500	14	of	of	ADP
fnp-3806	2500	15	nmda	nmda	ADJ
fnp-3806	2500	16	receptors	receptor	NOUN
fnp-3806	2500	17	in	in	ADP
fnp-3806	2500	18	alzheimer	alzheimer	PROPN
fnp-3806	2500	19	's	's	PART
fnp-3806	2500	20	disease	disease	NOUN
fnp-3806	2500	21	.	.	PUNCT
fnp-3806	2501	1	neurol	neurol	PROPN
fnp-3806	2501	2	sci	sci	PROPN
fnp-3806	2501	3	2016;37:1039	2016;37:1039	PROPN
fnp-3806	2501	4	-	-	SYM
fnp-3806	2501	5	1047	1047	NUM
fnp-3806	2501	6	.	.	PUNCT
fnp-3806	2502	1	https://doi.org/10.1007/s10072-016-2546-5	https://doi.org/10.1007/s10072-016-2546-5	NUM
fnp-3806	2502	2	foster	foster	PROPN
fnp-3806	2502	3	tc	tc	PROPN
fnp-3806	2502	4	,	,	PUNCT
fnp-3806	2502	5	kyritsopoulos	kyritsopoulos	PROPN
fnp-3806	2502	6	c	c	PROPN
fnp-3806	2502	7	,	,	PUNCT
fnp-3806	2502	8	kumar	kumar	PROPN
fnp-3806	2502	9	a.	a.	PROPN
fnp-3806	2502	10	central	central	ADJ
fnp-3806	2502	11	role	role	NOUN
fnp-3806	2502	12	for	for	ADP
fnp-3806	2502	13	nmda	nmda	ADJ
fnp-3806	2502	14	receptors	receptor	NOUN
fnp-3806	2502	15	in	in	ADP
fnp-3806	2502	16	redox	redox	ADJ
fnp-3806	2502	17	mediated	mediate	VERB
fnp-3806	2502	18	impairment	impairment	NOUN
fnp-3806	2502	19	of	of	ADP
fnp-3806	2502	20	synaptic	synaptic	ADJ
fnp-3806	2502	21	function	function	NOUN
fnp-3806	2502	22	during	during	ADP
fnp-3806	2502	23	aging	age	VERB
fnp-3806	2502	24	and	and	CCONJ
fnp-3806	2502	25	alzheimer	alzheimer	NOUN
fnp-3806	2502	26	's	's	PART
fnp-3806	2502	27	disease	disease	NOUN
fnp-3806	2502	28	.	.	PUNCT
fnp-3806	2503	1	behav	behav	NOUN
fnp-3806	2503	2	brain	brain	NOUN
fnp-3806	2503	3	res	re	NOUN
fnp-3806	2503	4	2017;322:223	2017;322:223	NUM
fnp-3806	2503	5	-	-	SYM
fnp-3806	2503	6	232	232	NUM
fnp-3806	2503	7	.	.	PUNCT
fnp-3806	2504	1	https://doi.org/10.1016/j.bbr.2016.05.012	https://doi.org/10.1016/j.bbr.2016.05.012	NOUN
fnp-3806	2504	2	babaei	babaei	NOUN
fnp-3806	2504	3	p.	p.	NOUN
fnp-3806	2504	4	nmda	nmda	PROPN
fnp-3806	2504	5	and	and	CCONJ
fnp-3806	2504	6	ampa	ampa	NOUN
fnp-3806	2504	7	receptors	receptor	NOUN
fnp-3806	2504	8	dysregulation	dysregulation	NOUN
fnp-3806	2504	9	in	in	ADP
fnp-3806	2504	10	alzheimer	alzheimer	PROPN
fnp-3806	2504	11	's	's	PART
fnp-3806	2504	12	disease	disease	NOUN
fnp-3806	2504	13	.	.	PUNCT
fnp-3806	2505	1	eur	eur	PROPN
fnp-3806	2505	2	j	j	PROPN
fnp-3806	2505	3	pharmacol	pharmacol	PROPN
fnp-3806	2505	4	2021;908:174310	2021;908:174310	NUM
fnp-3806	2505	5	.	.	PUNCT
fnp-3806	2506	1	https://doi.org/10.1016/j.ejphar.2021.174310	https://doi.org/10.1016/j.ejphar.2021.174310	PROPN
fnp-3806	2506	2	reinders	reinder	VERB
fnp-3806	2506	3	nr	nr	PROPN
fnp-3806	2506	4	,	,	PUNCT
fnp-3806	2506	5	pao	pao	PROPN
fnp-3806	2506	6	y	y	PROPN
fnp-3806	2506	7	,	,	PUNCT
fnp-3806	2506	8	renner	renner	PROPN
fnp-3806	2506	9	mc	mc	PROPN
fnp-3806	2506	10	,	,	PUNCT
fnp-3806	2506	11	et	et	PROPN
fnp-3806	2506	12	al	al	PROPN
fnp-3806	2506	13	.	.	PUNCT
fnp-3806	2507	1	effects	effect	NOUN
fnp-3806	2507	2	of	of	ADP
fnp-3806	2507	3	amyloid	amyloid	NOUN
fnp-3806	2507	4	-	-	PUNCT
fnp-3806	2507	5	β	β	NOUN
fnp-3806	2507	6	require	require	VERB
fnp-3806	2507	7	ampar	ampar	ADP
fnp-3806	2507	8	subunit	subunit	PROPN
fnp-3806	2507	9	glua3	glua3	PROPN
fnp-3806	2507	10	.	.	PUNCT
fnp-3806	2508	1	proc	proc	PROPN
fnp-3806	2508	2	natl	natl	PROPN
fnp-3806	2508	3	acad	acad	PROPN
fnp-3806	2508	4	sci	sci	PROPN
fnp-3806	2508	5	usa	usa	PROPN
fnp-3806	2508	6	2016;113	2016;113	NUM
fnp-3806	2508	7	:	:	PUNCT
fnp-3806	2509	1	e6526	e6526	PROPN
fnp-3806	2509	2	-	-	PUNCT
fnp-3806	2509	3	e6534	e6534	PROPN
fnp-3806	2509	4	.	.	PUNCT
fnp-3806	2509	5	https://doi.org/10.1073/pnas.1614249113	https://doi.org/10.1073/pnas.1614249113	PROPN
fnp-3806	2509	6	zhang	zhang	PROPN
fnp-3806	2509	7	y	y	PROPN
fnp-3806	2509	8	,	,	PUNCT
fnp-3806	2509	9	guo	guo	PROPN
fnp-3806	2509	10	o	o	NOUN
fnp-3806	2509	11	,	,	PUNCT
fnp-3806	2509	12	huo	huo	PROPN
fnp-3806	2509	13	y	y	PROPN
fnp-3806	2509	14	,	,	PUNCT
fnp-3806	2509	15	et	et	PROPN
fnp-3806	2509	16	al	al	PROPN
fnp-3806	2509	17	.	.	PUNCT
fnp-3806	2509	18	amyloid	amyloid	PROPN
fnp-3806	2509	19	-	-	PUNCT
fnp-3806	2509	20	β	β	PROPN
fnp-3806	2509	21	induces	induce	VERB
fnp-3806	2509	22	ampa	ampa	NOUN
fnp-3806	2509	23	receptor	receptor	NOUN
fnp-3806	2509	24	ubiquitination	ubiquitination	NOUN
fnp-3806	2509	25	and	and	CCONJ
fnp-3806	2509	26	degradation	degradation	NOUN
fnp-3806	2509	27	in	in	ADP
fnp-3806	2509	28	primary	primary	ADJ
fnp-3806	2509	29	neurons	neuron	NOUN
fnp-3806	2509	30	and	and	CCONJ
fnp-3806	2509	31	human	human	ADJ
fnp-3806	2509	32	brains	brain	NOUN
fnp-3806	2509	33	of	of	ADP
fnp-3806	2509	34	alzheimer	alzheimer	PROPN
fnp-3806	2509	35	’s	’s	PART
fnp-3806	2509	36	disease	disease	NOUN
fnp-3806	2509	37	.	.	PUNCT
fnp-3806	2510	1	j	j	PROPN
fnp-3806	2510	2	alzheimer	alzheimer	PROPN
fnp-3806	2510	3	’s	’s	PART
fnp-3806	2510	4	dis	dis	PROPN
fnp-3806	2510	5	2018;62:1789	2018;62:1789	PROPN
fnp-3806	2510	6	-	-	SYM
fnp-3806	2510	7	1801	1801	NUM
fnp-3806	2510	8	.	.	PUNCT
fnp-3806	2511	1	https://doi.org/10.3233/jad-170879	https://doi.org/10.3233/jad-170879	PROPN
fnp-3806	2511	2	danbolt	danbolt	PROPN
fnp-3806	2511	3	nc	nc	PROPN
fnp-3806	2511	4	.	.	PROPN
fnp-3806	2511	5	glutamate	glutamate	VERB
fnp-3806	2511	6	uptake	uptake	NOUN
fnp-3806	2511	7	.	.	PUNCT
fnp-3806	2512	1	prog	prog	PROPN
fnp-3806	2512	2	neurobiol	neurobiol	PROPN
fnp-3806	2512	3	2001;65:1	2001;65:1	NUM
fnp-3806	2512	4	-	-	SYM
fnp-3806	2512	5	105	105	NUM
fnp-3806	2512	6	.	.	PUNCT
fnp-3806	2513	1	https://doi.org/10.1016/s0301-0082(00)00067-8	https://doi.org/10.1016/s0301-0082(00)00067-8	PROPN
fnp-3806	2513	2	kirvell	kirvell	PROPN
fnp-3806	2513	3	sl	sl	PROPN
fnp-3806	2513	4	,	,	PUNCT
fnp-3806	2513	5	esiri	esiri	PROPN
fnp-3806	2513	6	m	m	PROPN
fnp-3806	2513	7	,	,	PUNCT
fnp-3806	2513	8	francis	francis	PROPN
fnp-3806	2513	9	pt	pt	PROPN
fnp-3806	2513	10	.	.	PROPN
fnp-3806	2513	11	down	down	ADP
fnp-3806	2513	12	-	-	PUNCT
fnp-3806	2513	13	regulation	regulation	NOUN
fnp-3806	2513	14	of	of	ADP
fnp-3806	2513	15	vesicular	vesicular	ADJ
fnp-3806	2513	16	glutamate	glutamate	NOUN
fnp-3806	2513	17	transporters	transporter	NOUN
fnp-3806	2513	18	precedes	precede	VERB
fnp-3806	2513	19	cell	cell	NOUN
fnp-3806	2513	20	loss	loss	NOUN
fnp-3806	2513	21	and	and	CCONJ
fnp-3806	2513	22	pathology	pathology	NOUN
fnp-3806	2513	23	in	in	ADP
fnp-3806	2513	24	alzheimer	alzheimer	PROPN
fnp-3806	2513	25	's	's	PART
fnp-3806	2513	26	disease	disease	NOUN
fnp-3806	2513	27	.	.	PUNCT
fnp-3806	2514	1	j	j	PROPN
fnp-3806	2514	2	neurochem	neurochem	PROPN
fnp-3806	2514	3	2006;98:939	2006;98:939	PROPN
fnp-3806	2514	4	-	-	SYM
fnp-3806	2514	5	950	950	NUM
fnp-3806	2514	6	.	.	PUNCT
fnp-3806	2515	1	https://doi.org/10.1111/j.1471-4159.2006.03935.x	https://doi.org/10.1111/j.1471-4159.2006.03935.x	PROPN
fnp-3806	2515	2	jacob	jacob	PROPN
fnp-3806	2515	3	cp	cp	PROPN
fnp-3806	2515	4	,	,	PUNCT
fnp-3806	2515	5	koutsilieri	koutsilieri	ADJ
fnp-3806	2515	6	e	e	NOUN
fnp-3806	2515	7	,	,	PUNCT
fnp-3806	2515	8	bartl	bartl	PROPN
fnp-3806	2515	9	j	j	PROPN
fnp-3806	2515	10	,	,	PUNCT
fnp-3806	2515	11	et	et	PROPN
fnp-3806	2515	12	al	al	PROPN
fnp-3806	2515	13	.	.	PUNCT
fnp-3806	2515	14	alterations	alteration	NOUN
fnp-3806	2515	15	in	in	ADP
fnp-3806	2515	16	expression	expression	NOUN
fnp-3806	2515	17	of	of	ADP
fnp-3806	2515	18	glutamatergic	glutamatergic	ADJ
fnp-3806	2515	19	transporters	transporter	NOUN
fnp-3806	2515	20	and	and	CCONJ
fnp-3806	2515	21	receptors	receptor	NOUN
fnp-3806	2515	22	in	in	ADP
fnp-3806	2515	23	sporadic	sporadic	ADJ
fnp-3806	2515	24	alzheimer	alzheimer	PROPN
fnp-3806	2515	25	's	's	PART
fnp-3806	2515	26	disease	disease	NOUN
fnp-3806	2515	27	.	.	PUNCT
fnp-3806	2516	1	j	j	PROPN
fnp-3806	2516	2	alzheimers	alzheimers	PROPN
fnp-3806	2516	3	dis	dis	PROPN
fnp-3806	2516	4	2007	2007	NUM
fnp-3806	2516	5	;	;	PUNCT
fnp-3806	2516	6	11:97	11:97	NUM
fnp-3806	2516	7	-	-	SYM
fnp-3806	2516	8	116	116	NUM
fnp-3806	2516	9	.	.	PUNCT
fnp-3806	2517	1	https://doi.org/10.3233/jad-2007-11113	https://doi.org/10.3233/jad-2007-11113	PROPN
fnp-3806	2517	2	pow	pow	PROPN
fnp-3806	2517	3	dv	dv	PROPN
fnp-3806	2517	4	,	,	PUNCT
fnp-3806	2517	5	cook	cook	VERB
fnp-3806	2517	6	dg.neuronal	dg.neuronal	ADJ
fnp-3806	2517	7	expression	expression	NOUN
fnp-3806	2517	8	of	of	ADP
fnp-3806	2517	9	splice	splice	NOUN
fnp-3806	2517	10	variants	variant	NOUN
fnp-3806	2517	11	of	of	ADP
fnp-3806	2517	12	"	"	PUNCT
fnp-3806	2517	13	glial	glial	ADJ
fnp-3806	2517	14	"	"	PUNCT
fnp-3806	2517	15	glutamate	glutamate	NOUN
fnp-3806	2517	16	transporters	transporter	NOUN
fnp-3806	2517	17	in	in	ADP
fnp-3806	2517	18	brains	brain	NOUN
fnp-3806	2517	19	afflicted	afflict	VERB
fnp-3806	2517	20	by	by	ADP
fnp-3806	2517	21	alzheimer	alzheimer	PROPN
fnp-3806	2517	22	's	's	PART
fnp-3806	2517	23	disease	disease	NOUN
fnp-3806	2517	24	:	:	PUNCT
fnp-3806	2517	25	unmasking	unmask	VERB
fnp-3806	2517	26	an	an	DET
fnp-3806	2517	27	intrinsic	intrinsic	ADJ
fnp-3806	2517	28	neuronal	neuronal	ADJ
fnp-3806	2517	29	property	property	NOUN
fnp-3806	2517	30	.	.	PUNCT
fnp-3806	2518	1	neurochem	neurochem	PROPN
fnp-3806	2518	2	res	re	VERB
fnp-3806	2518	3	2009;34:1748	2009;34:1748	NOUN
fnp-3806	2518	4	-	-	PUNCT
fnp-3806	2518	5	1757	1757	NUM
fnp-3806	2518	6	.	.	PUNCT
fnp-3806	2519	1	https://doi.org/10.1007/s11064-009-9957-0	https://doi.org/10.1007/s11064-009-9957-0	PROPN
fnp-3806	2519	2	conn	conn	PROPN
fnp-3806	2519	3	pj	pj	PROPN
fnp-3806	2519	4	,	,	PUNCT
fnp-3806	2519	5	pin	pin	PROPN
fnp-3806	2519	6	jp	jp	NOUN
fnp-3806	2519	7	.	.	PUNCT
fnp-3806	2520	1	pharmacology	pharmacology	NOUN
fnp-3806	2520	2	and	and	CCONJ
fnp-3806	2520	3	functions	function	NOUN
fnp-3806	2520	4	of	of	ADP
fnp-3806	2520	5	metabotropic	metabotropic	NOUN
fnp-3806	2520	6	glutamate	glutamate	NOUN
fnp-3806	2520	7	receptors	receptor	NOUN
fnp-3806	2520	8	.	.	PUNCT
fnp-3806	2521	1	annu	annu	PROPN
fnp-3806	2521	2	rev	rev	VERB
fnp-3806	2521	3	pharmacol	pharmacol	PROPN
fnp-3806	2521	4	toxicol	toxicol	PROPN
fnp-3806	2521	5	1997	1997	NUM
fnp-3806	2521	6	;	;	PUNCT
fnp-3806	2521	7	37	37	NUM
fnp-3806	2521	8	:	:	SYM
fnp-3806	2521	9	205	205	NUM
fnp-3806	2521	10	-	-	SYM
fnp-3806	2521	11	237	237	NUM
fnp-3806	2521	12	.	.	PUNCT
fnp-3806	2521	13	https://doi.org/10.1146/annurev.pharmtox.37.1.205	https://doi.org/10.1146/annurev.pharmtox.37.1.205	PROPN
fnp-3806	2521	14	pin	pin	PROPN
fnp-3806	2521	15	jp	jp	PROPN
fnp-3806	2521	16	,	,	PUNCT
fnp-3806	2521	17	duvoisin	duvoisin	VERB
fnp-3806	2521	18	r.	r.	PROPN
fnp-3806	2521	19	the	the	DET
fnp-3806	2521	20	metabotropic	metabotropic	NOUN
fnp-3806	2521	21	glutamate	glutamate	NOUN
fnp-3806	2521	22	receptors	receptor	NOUN
fnp-3806	2521	23	:	:	PUNCT
fnp-3806	2521	24	structure	structure	NOUN
fnp-3806	2521	25	and	and	CCONJ
fnp-3806	2521	26	functions	function	NOUN
fnp-3806	2521	27	.	.	PUNCT
fnp-3806	2522	1	neuropharmacology	neuropharmacology	NOUN
fnp-3806	2522	2	1995;3:1	1995;3:1	NOUN
fnp-3806	2522	3	-	-	SYM
fnp-3806	2522	4	26	26	NUM
fnp-3806	2522	5	.	.	PUNCT
fnp-3806	2523	1	https://doi.org/10.1016/0028-3908(94)00129-g	https://doi.org/10.1016/0028-3908(94)00129-g	VERB
fnp-3806	2523	2	crupi	crupi	PROPN
fnp-3806	2523	3	r	r	NOUN
fnp-3806	2523	4	,	,	PUNCT
fnp-3806	2523	5	impellizeri	impellizeri	ADJ
fnp-3806	2523	6	d	d	NOUN
fnp-3806	2523	7	,	,	PUNCT
fnp-3806	2523	8	cuzzocrea	cuzzocrea	PROPN
fnp-3806	2523	9	s.	s.	PROPN
fnp-3806	2523	10	role	role	NOUN
fnp-3806	2523	11	of	of	ADP
fnp-3806	2523	12	metabotropic	metabotropic	NOUN
fnp-3806	2523	13	glutamate	glutamate	NOUN
fnp-3806	2523	14	receptors	receptor	NOUN
fnp-3806	2523	15	in	in	ADP
fnp-3806	2523	16	neurological	neurological	ADJ
fnp-3806	2523	17	disorders	disorder	NOUN
fnp-3806	2523	18	.	.	PUNCT
fnp-3806	2524	1	front	front	NOUN
fnp-3806	2524	2	mol	mol	ADP
fnp-3806	2524	3	neurosci	neurosci	PROPN
fnp-3806	2524	4	2019;12:20	2019;12:20	NUM
fnp-3806	2524	5	.	.	PUNCT
fnp-3806	2525	1	https://doi.org/10.3389/fnmol.2019.00020	https://doi.org/10.3389/fnmol.2019.00020	PROPN
fnp-3806	2525	2	mao	mao	PROPN
fnp-3806	2525	3	lm	lm	PROPN
fnp-3806	2525	4	,	,	PUNCT
fnp-3806	2525	5	bodepudi	bodepudi	PROPN
fnp-3806	2525	6	a	a	PROPN
fnp-3806	2525	7	,	,	PUNCT
fnp-3806	2525	8	chu	chu	PROPN
fnp-3806	2525	9	xp	xp	PROPN
fnp-3806	2525	10	,	,	PUNCT
fnp-3806	2525	11	et	et	PROPN
fnp-3806	2525	12	al	al	PROPN
fnp-3806	2525	13	.	.	PROPN
fnp-3806	2525	14	group	group	NOUN
fnp-3806	2525	15	i	i	PRON
fnp-3806	2525	16	metabotropic	metabotropic	VERB
fnp-3806	2525	17	glutamate	glutamate	NOUN
fnp-3806	2525	18	receptors	receptor	NOUN
fnp-3806	2525	19	and	and	CCONJ
fnp-3806	2525	20	interacting	interact	VERB
fnp-3806	2525	21	partners	partner	NOUN
fnp-3806	2525	22	:	:	PUNCT
fnp-3806	2525	23	an	an	DET
fnp-3806	2525	24	update	update	NOUN
fnp-3806	2525	25	.	.	PUNCT
fnp-3806	2526	1	int	int	PROPN
fnp-3806	2526	2	j	j	PROPN
fnp-3806	2526	3	mol	mol	ADP
fnp-3806	2526	4	sci	sci	PROPN
fnp-3806	2526	5	2022;23:840	2022;23:840	NOUN
fnp-3806	2526	6	.	.	PUNCT
fnp-3806	2527	1	https://doi.org/10.3390/ijms23020840	https://doi.org/10.3390/ijms23020840	PROPN
fnp-3806	2527	2	albasanz	albasanz	PROPN
fnp-3806	2527	3	jl	jl	NOUN
fnp-3806	2527	4	,	,	PUNCT
fnp-3806	2527	5	dalfó	dalfó	ADJ
fnp-3806	2527	6	e	e	NOUN
fnp-3806	2527	7	,	,	PUNCT
fnp-3806	2527	8	ferrer	ferrer	PROPN
fnp-3806	2527	9	i	i	PROPN
fnp-3806	2527	10	,	,	PUNCT
fnp-3806	2527	11	et	et	PROPN
fnp-3806	2527	12	al	al	PROPN
fnp-3806	2527	13	.	.	PUNCT
fnp-3806	2527	14	impaired	impair	VERB
fnp-3806	2527	15	metabotropic	metabotropic	NOUN
fnp-3806	2527	16	glutamate	glutamate	NOUN
fnp-3806	2527	17	receptor	receptor	NOUN
fnp-3806	2527	18	/	/	SYM
fnp-3806	2527	19	phospholipase	phospholipase	NOUN
fnp-3806	2527	20	c	c	NOUN
fnp-3806	2527	21	signaling	signal	VERB
fnp-3806	2527	22	pathway	pathway	NOUN
fnp-3806	2527	23	in	in	ADP
fnp-3806	2527	24	the	the	DET
fnp-3806	2527	25	cerebral	cerebral	ADJ
fnp-3806	2527	26	cortex	cortex	NOUN
fnp-3806	2527	27	in	in	ADP
fnp-3806	2527	28	alzheimer	alzheimer	PROPN
fnp-3806	2527	29	's	's	PART
fnp-3806	2527	30	disease	disease	NOUN
fnp-3806	2527	31	and	and	CCONJ
fnp-3806	2527	32	dementia	dementia	NOUN
fnp-3806	2527	33	with	with	ADP
fnp-3806	2527	34	lewy	lewy	ADJ
fnp-3806	2527	35	bodies	body	NOUN
fnp-3806	2527	36	correlates	correlate	VERB
fnp-3806	2527	37	with	with	ADP
fnp-3806	2527	38	stage	stage	NOUN
fnp-3806	2527	39	of	of	ADP
fnp-3806	2527	40	alzheimer's	alzheimer's	NOUN
fnp-3806	2527	41	-	-	PUNCT
fnp-3806	2527	42	disease	disease	NOUN
fnp-3806	2527	43	-	-	PUNCT
fnp-3806	2527	44	related	relate	VERB
fnp-3806	2527	45	changes	change	NOUN
fnp-3806	2527	46	.	.	PUNCT
fnp-3806	2528	1	neurobiol	neurobiol	PROPN
fnp-3806	2528	2	dis	dis	PROPN
fnp-3806	2528	3	2005;20:685	2005;20:685	NUM
fnp-3806	2528	4	-	-	SYM
fnp-3806	2528	5	693	693	NUM
fnp-3806	2528	6	.	.	PUNCT
fnp-3806	2529	1	https://doi.org/10.1016/j.nbd.2005.05.001	https://doi.org/10.1016/j.nbd.2005.05.001	PROPN
fnp-3806	2529	2	goetz	goetz	PROPN
fnp-3806	2529	3	t	t	PROPN
fnp-3806	2529	4	,	,	PUNCT
fnp-3806	2529	5	arslan	arslan	PROPN
fnp-3806	2529	6	a	a	PROPN
fnp-3806	2529	7	,	,	PUNCT
fnp-3806	2529	8	wisden	wisden	ADJ
fnp-3806	2529	9	w	w	NOUN
fnp-3806	2529	10	,	,	PUNCT
fnp-3806	2529	11	et	et	PROPN
fnp-3806	2529	12	al	al	PROPN
fnp-3806	2529	13	.	.	PROPN
fnp-3806	2529	14	gaba(a	gaba(a	PROPN
fnp-3806	2529	15	)	)	PUNCT
fnp-3806	2529	16	receptors	receptor	NOUN
fnp-3806	2529	17	:	:	PUNCT
fnp-3806	2529	18	structure	structure	NOUN
fnp-3806	2529	19	and	and	CCONJ
fnp-3806	2529	20	function	function	NOUN
fnp-3806	2529	21	in	in	ADP
fnp-3806	2529	22	the	the	DET
fnp-3806	2529	23	basal	basal	ADJ
fnp-3806	2529	24	ganglia	ganglia	NOUN
fnp-3806	2529	25	.	.	PUNCT
fnp-3806	2530	1	prog	prog	NOUN
fnp-3806	2530	2	brain	brain	NOUN
fnp-3806	2530	3	res	re	NOUN
fnp-3806	2530	4	2007;160:21	2007;160:21	NUM
fnp-3806	2530	5	-	-	SYM
fnp-3806	2530	6	41	41	NUM
fnp-3806	2530	7	.	.	PUNCT
fnp-3806	2531	1	https://doi.org/10.1016/s0079-6123(06)60003-4	https://doi.org/10.1016/s0079-6123(06)60003-4	PROPN
fnp-3806	2531	2	padgett	padgett	PROPN
fnp-3806	2531	3	cl	cl	PROPN
fnp-3806	2531	4	,	,	PUNCT
fnp-3806	2531	5	slesinger	slesinger	NOUN
fnp-3806	2531	6	pa	pa	PROPN
fnp-3806	2531	7	.	.	PROPN
fnp-3806	2531	8	gabab	gabab	PROPN
fnp-3806	2531	9	receptor	receptor	NOUN
fnp-3806	2531	10	coupling	coupling	NOUN
fnp-3806	2531	11	to	to	ADP
fnp-3806	2531	12	g	g	NOUN
fnp-3806	2531	13	-	-	PUNCT
fnp-3806	2531	14	proteins	protein	NOUN
fnp-3806	2531	15	and	and	CCONJ
fnp-3806	2531	16	ion	ion	NOUN
fnp-3806	2531	17	channels	channel	NOUN
fnp-3806	2531	18	.	.	PUNCT
fnp-3806	2532	1	adv	adv	PROPN
fnp-3806	2532	2	pharmacol	pharmacol	PROPN
fnp-3806	2532	3	sci	sci	PROPN
fnp-3806	2532	4	2010;58:123	2010;58:123	PROPN
fnp-3806	2532	5	-	-	SYM
fnp-3806	2532	6	147	147	NUM
fnp-3806	2532	7	.	.	PUNCT
fnp-3806	2533	1	https://doi.org/10.1016/s1054-3589(10)58006-2	https://doi.org/10.1016/s1054-3589(10)58006-2	VERB
fnp-3806	2533	2	jembrek	jembrek	PROPN
fnp-3806	2533	3	mj	mj	PROPN
fnp-3806	2533	4	,	,	PUNCT
fnp-3806	2533	5	vlainic	vlainic	PROPN
fnp-3806	2533	6	j.	j.	PROPN
fnp-3806	2533	7	gaba	gaba	PROPN
fnp-3806	2533	8	receptors	receptor	NOUN
fnp-3806	2533	9	:	:	PUNCT
fnp-3806	2533	10	pharmacological	pharmacological	ADJ
fnp-3806	2533	11	potential	potential	NOUN
fnp-3806	2533	12	and	and	CCONJ
fnp-3806	2533	13	pitfalls	pitfall	NOUN
fnp-3806	2533	14	.	.	PUNCT
fnp-3806	2534	1	curr	curr	PROPN
fnp-3806	2534	2	pharm	pharm	PROPN
fnp-3806	2534	3	des	des	PROPN
fnp-3806	2534	4	2015;21:4943	2015;21:4943	NUM
fnp-3806	2534	5	-	-	SYM
fnp-3806	2534	6	4959	4959	NUM
fnp-3806	2534	7	.	.	PUNCT
fnp-3806	2535	1	https://doi.org/10.2174/1381612821666150914121624	https://doi.org/10.2174/1381612821666150914121624	PROPN
fnp-3806	2535	2	terunuma	terunuma	PROPN
fnp-3806	2535	3	m.	m.	NOUN
fnp-3806	2535	4	diversity	diversity	NOUN
fnp-3806	2535	5	of	of	ADP
fnp-3806	2535	6	structure	structure	NOUN
fnp-3806	2535	7	and	and	CCONJ
fnp-3806	2535	8	function	function	NOUN
fnp-3806	2535	9	of	of	ADP
fnp-3806	2535	10	gaba(b	gaba(b	NOUN
fnp-3806	2535	11	)	)	PUNCT
fnp-3806	2535	12	receptors	receptor	NOUN
fnp-3806	2535	13	:	:	PUNCT
fnp-3806	2535	14	a	a	DET
fnp-3806	2535	15	complexity	complexity	NOUN
fnp-3806	2535	16	of	of	ADP
fnp-3806	2535	17	gaba(b)-mediated	gaba(b)-mediate	VERB
fnp-3806	2535	18	signaling	signal	VERB
fnp-3806	2535	19	.	.	PUNCT
fnp-3806	2536	1	proc	proc	PROPN
fnp-3806	2536	2	jpn	jpn	PROPN
fnp-3806	2536	3	acad	acad	PROPN
fnp-3806	2536	4	ser	ser	PROPN
fnp-3806	2536	5	b	b	PROPN
fnp-3806	2536	6	phys	phy	NOUN
fnp-3806	2536	7	biol	biol	VERB
fnp-3806	2536	8	sci	sci	PROPN
fnp-3806	2536	9	2018;94:390	2018;94:390	PROPN
fnp-3806	2536	10	-	-	SYM
fnp-3806	2536	11	411	411	NUM
fnp-3806	2536	12	.	.	PUNCT
fnp-3806	2537	1	https://doi.org/10.2183/pjab.94.026	https://doi.org/10.2183/pjab.94.026	PROPN
fnp-3806	2537	2	bak	bak	VERB
fnp-3806	2537	3	lk	lk	PROPN
fnp-3806	2537	4	,	,	PUNCT
fnp-3806	2537	5	schousboe	schousboe	VERB
fnp-3806	2537	6	a	a	PRON
fnp-3806	2537	7	,	,	PUNCT
fnp-3806	2537	8	waagepetersen	waagepetersen	PROPN
fnp-3806	2537	9	hs	hs	PROPN
fnp-3806	2537	10	.	.	PUNCT
fnp-3806	2538	1	the	the	DET
fnp-3806	2538	2	glutamate	glutamate	NOUN
fnp-3806	2538	3	/	/	SYM
fnp-3806	2538	4	gaba	gaba	NOUN
fnp-3806	2538	5	-	-	PUNCT
fnp-3806	2538	6	glutamine	glutamine	NOUN
fnp-3806	2538	7	cycle	cycle	NOUN
fnp-3806	2538	8	:	:	PUNCT
fnp-3806	2538	9	aspects	aspect	NOUN
fnp-3806	2538	10	of	of	ADP
fnp-3806	2538	11	transport	transport	NOUN
fnp-3806	2538	12	,	,	PUNCT
fnp-3806	2538	13	neurotransmitter	neurotransmitter	NOUN
fnp-3806	2538	14	homeostasis	homeostasis	NOUN
fnp-3806	2538	15	and	and	CCONJ
fnp-3806	2538	16	ammonia	ammonia	NOUN
fnp-3806	2538	17	transfer	transfer	NOUN
fnp-3806	2538	18	.	.	PUNCT
fnp-3806	2539	1	j	j	PROPN
fnp-3806	2539	2	neurochem	neurochem	PROPN
fnp-3806	2539	3	2006;98:641	2006;98:641	PROPN
fnp-3806	2539	4	-	-	NOUN
fnp-3806	2539	5	653	653	NUM
fnp-3806	2539	6	.	.	PUNCT
fnp-3806	2540	1	https://doi.org/10.1111/j.1471-4159.2006.03913.x	https://doi.org/10.1111/j.1471-4159.2006.03913.x	X
fnp-3806	2541	1	leke	leke	PROPN
fnp-3806	2541	2	r	r	NOUN
fnp-3806	2541	3	,	,	PUNCT
fnp-3806	2541	4	schousboe	schousboe	ADJ
fnp-3806	2541	5	a.	a.	NOUN
fnp-3806	2541	6	the	the	DET
fnp-3806	2541	7	glutamine	glutamine	NOUN
fnp-3806	2541	8	transporters	transporter	NOUN
fnp-3806	2541	9	and	and	CCONJ
fnp-3806	2541	10	their	their	PRON
fnp-3806	2541	11	role	role	NOUN
fnp-3806	2541	12	in	in	ADP
fnp-3806	2541	13	the	the	DET
fnp-3806	2541	14	glutamate	glutamate	NOUN
fnp-3806	2541	15	/	/	SYM
fnp-3806	2541	16	gaba	gaba	NOUN
fnp-3806	2541	17	-	-	PUNCT
fnp-3806	2541	18	glutamine	glutamine	NOUN
fnp-3806	2541	19	cycle	cycle	NOUN
fnp-3806	2541	20	.	.	PUNCT
fnp-3806	2542	1	adv	adv	PROPN
fnp-3806	2542	2	neurobiol	neurobiol	VERB
fnp-3806	2542	3	2016;13:223	2016;13:223	NUM
fnp-3806	2542	4	-	-	SYM
fnp-3806	2542	5	257	257	NUM
fnp-3806	2542	6	.	.	PUNCT
fnp-3806	2543	1	https://doi.org/10.1007/978-3-319-45096-4_8	https://doi.org/10.1007/978-3-319-45096-4_8	PROPN
fnp-3806	2543	2	yoon	yoon	PROPN
fnp-3806	2543	3	be	be	PROPN
fnp-3806	2543	4	,	,	PUNCT
fnp-3806	2543	5	lee	lee	PROPN
fnp-3806	2543	6	cj	cj	PROPN
fnp-3806	2543	7	.	.	PUNCT
fnp-3806	2544	1	gaba	gaba	PROPN
fnp-3806	2544	2	as	as	ADP
fnp-3806	2544	3	a	a	DET
fnp-3806	2544	4	rising	rise	VERB
fnp-3806	2544	5	gliotransmitter	gliotransmitter	NOUN
fnp-3806	2544	6	.	.	PUNCT
fnp-3806	2545	1	front	front	ADJ
fnp-3806	2545	2	neural	neural	ADJ
fnp-3806	2545	3	circuits	circuit	NOUN
fnp-3806	2545	4	2014;8:141	2014;8:141	NOUN
fnp-3806	2545	5	.	.	PUNCT
fnp-3806	2546	1	https://doi.org/10.3389/fncir.2014.00141	https://doi.org/10.3389/fncir.2014.00141	PROPN
fnp-3806	2546	2	ambrad	ambrad	NOUN
fnp-3806	2546	3	giovannetti	giovannetti	NOUN
fnp-3806	2546	4	e	e	NOUN
fnp-3806	2546	5	,	,	PUNCT
fnp-3806	2546	6	fuhrmann	fuhrmann	ADJ
fnp-3806	2546	7	m.	m.	NOUN
fnp-3806	2546	8	unsupervised	unsupervised	ADJ
fnp-3806	2546	9	excitation	excitation	NOUN
fnp-3806	2546	10	:	:	PUNCT
fnp-3806	2546	11	gabaergic	gabaergic	ADJ
fnp-3806	2546	12	dysfunctions	dysfunction	NOUN
fnp-3806	2546	13	in	in	ADP
fnp-3806	2546	14	alzheimer	alzheimer	PROPN
fnp-3806	2546	15	's	's	PART
fnp-3806	2546	16	disease	disease	NOUN
fnp-3806	2546	17	.	.	PUNCT
fnp-3806	2547	1	brain	brain	NOUN
fnp-3806	2547	2	res	re	NOUN
fnp-3806	2547	3	2019;1707:216	2019;1707:216	PROPN
fnp-3806	2547	4	-	-	SYM
fnp-3806	2547	5	226	226	NUM
fnp-3806	2547	6	.	.	PUNCT
fnp-3806	2548	1	https://doi.org/10.1016/j.brainres.2018.11.042	https://doi.org/10.1016/j.brainres.2018.11.042	NUM
fnp-3806	2548	2	calvo	calvo	NOUN
fnp-3806	2548	3	-	-	PUNCT
fnp-3806	2548	4	flores	flores	PROPN
fnp-3806	2548	5	guzmán	guzmán	PROPN
fnp-3806	2548	6	b	b	PROPN
fnp-3806	2548	7	,	,	PUNCT
fnp-3806	2548	8	vinnakota	vinnakota	ADJ
fnp-3806	2548	9	c	c	NOUN
fnp-3806	2548	10	,	,	PUNCT
fnp-3806	2548	11	govindpani	govindpani	PROPN
fnp-3806	2548	12	k	k	PROPN
fnp-3806	2548	13	,	,	PUNCT
fnp-3806	2548	14	et	et	PROPN
fnp-3806	2548	15	al	al	PROPN
fnp-3806	2548	16	.	.	PUNCT
fnp-3806	2549	1	the	the	DET
fnp-3806	2549	2	gabaergic	gabaergic	ADJ
fnp-3806	2549	3	system	system	NOUN
fnp-3806	2549	4	as	as	ADP
fnp-3806	2549	5	a	a	DET
fnp-3806	2549	6	therapeutic	therapeutic	ADJ
fnp-3806	2549	7	target	target	NOUN
fnp-3806	2549	8	for	for	ADP
fnp-3806	2549	9	alzheimer	alzheimer	PROPN
fnp-3806	2549	10	's	's	PART
fnp-3806	2549	11	disease	disease	NOUN
fnp-3806	2549	12	.	.	PUNCT
fnp-3806	2550	1	j	j	PROPN
fnp-3806	2550	2	neurochem	neurochem	PROPN
fnp-3806	2550	3	2018;146:649	2018;146:649	PROPN
fnp-3806	2550	4	-	-	SYM
fnp-3806	2550	5	669	669	NUM
fnp-3806	2550	6	.	.	PUNCT
fnp-3806	2551	1	https://doi.org/10.1111/jnc.14345	https://doi.org/10.1111/jnc.14345	PROPN
fnp-3806	2551	2	govindpani	govindpani	PROPN
fnp-3806	2551	3	k	k	PROPN
fnp-3806	2551	4	,	,	PUNCT
fnp-3806	2551	5	calvo	calvo	NOUN
fnp-3806	2551	6	-	-	PUNCT
fnp-3806	2551	7	flores	flores	PROPN
fnp-3806	2551	8	guzmán	guzmán	PROPN
fnp-3806	2551	9	b	b	PROPN
fnp-3806	2551	10	,	,	PUNCT
fnp-3806	2551	11	et	et	PROPN
fnp-3806	2551	12	al	al	PROPN
fnp-3806	2551	13	.	.	PROPN
fnp-3806	2552	1	towards	towards	ADP
fnp-3806	2552	2	a	a	DET
fnp-3806	2552	3	better	well	ADJ
fnp-3806	2552	4	understanding	understanding	NOUN
fnp-3806	2552	5	of	of	ADP
fnp-3806	2552	6	gabaergic	gabaergic	ADJ
fnp-3806	2552	7	remodeling	remodeling	NOUN
fnp-3806	2552	8	in	in	ADP
fnp-3806	2552	9	alzheimer	alzheimer	PROPN
fnp-3806	2552	10	's	's	PART
fnp-3806	2552	11	disease	disease	NOUN
fnp-3806	2552	12	.	.	PUNCT
fnp-3806	2553	1	int	int	PROPN
fnp-3806	2553	2	j	j	PROPN
fnp-3806	2553	3	mol	mol	ADP
fnp-3806	2553	4	sci	sci	PROPN
fnp-3806	2553	5	2017;18	2017;18	NUM
fnp-3806	2553	6	:	:	PUNCT
fnp-3806	2553	7	1813	1813	NUM
fnp-3806	2553	8	.	.	PUNCT
fnp-3806	2554	1	https://doi.org/10.3390/ijms18081813	https://doi.org/10.3390/ijms18081813	PROPN
fnp-3806	2554	2	riese	riese	PROPN
fnp-3806	2554	3	f	f	PROPN
fnp-3806	2554	4	,	,	PUNCT
fnp-3806	2554	5	gietl	gietl	VERB
fnp-3806	2554	6	a	a	NOUN
fnp-3806	2554	7	,	,	PUNCT
fnp-3806	2554	8	zölch	zölch	NOUN
fnp-3806	2554	9	n	n	CCONJ
fnp-3806	2554	10	,	,	PUNCT
fnp-3806	2554	11	et	et	PROPN
fnp-3806	2554	12	al	al	PROPN
fnp-3806	2554	13	.	.	PUNCT
fnp-3806	2554	14	posterior	posterior	PROPN
fnp-3806	2554	15	cingulate	cingulate	PROPN
fnp-3806	2554	16	γ	γ	ADJ
fnp-3806	2554	17	-	-	ADJ
fnp-3806	2554	18	aminobutyric	aminobutyric	ADJ
fnp-3806	2554	19	acid	acid	NOUN
fnp-3806	2554	20	and	and	CCONJ
fnp-3806	2554	21	glutamate	glutamate	NOUN
fnp-3806	2554	22	/	/	SYM
fnp-3806	2554	23	glutamine	glutamine	NOUN
fnp-3806	2554	24	are	be	AUX
fnp-3806	2554	25	reduced	reduce	VERB
fnp-3806	2554	26	in	in	ADP
fnp-3806	2554	27	amnestic	amnestic	ADJ
fnp-3806	2554	28	mild	mild	ADJ
fnp-3806	2554	29	cognitive	cognitive	ADJ
fnp-3806	2554	30	impairment	impairment	NOUN
fnp-3806	2554	31	and	and	CCONJ
fnp-3806	2554	32	are	be	AUX
fnp-3806	2554	33	unrelated	unrelated	ADJ
fnp-3806	2554	34	to	to	PART
fnp-3806	2554	35	amyloid	amyloid	VERB
fnp-3806	2554	36	deposition	deposition	NOUN
fnp-3806	2554	37	and	and	CCONJ
fnp-3806	2554	38	apolipoprotein	apolipoprotein	NOUN
fnp-3806	2554	39	e	e	PROPN
fnp-3806	2554	40	genotype	genotype	NOUN
fnp-3806	2554	41	.	.	PUNCT
fnp-3806	2555	1	neurobiol	neurobiol	PROPN
fnp-3806	2555	2	aging	age	VERB
fnp-3806	2555	3	2015;36:53	2015;36:53	NUM
fnp-3806	2555	4	-	-	SYM
fnp-3806	2555	5	59	59	NUM
fnp-3806	2555	6	.	.	PUNCT
fnp-3806	2556	1	https://doi.org/10.1016/j.neurobiolaging.2014.07.030	https://doi.org/10.1016/j.neurobiolaging.2014.07.030	PROPN
fnp-3806	2556	2	huang	huang	PROPN
fnp-3806	2556	3	d	d	PROPN
fnp-3806	2556	4	,	,	PUNCT
fnp-3806	2556	5	liu	liu	PROPN
fnp-3806	2556	6	d	d	PROPN
fnp-3806	2556	7	,	,	PUNCT
fnp-3806	2556	8	yin	yin	PROPN
fnp-3806	2556	9	j	j	PROPN
fnp-3806	2556	10	,	,	PUNCT
fnp-3806	2556	11	et	et	PROPN
fnp-3806	2556	12	al	al	PROPN
fnp-3806	2556	13	.	.	PUNCT
fnp-3806	2556	14	glutamate	glutamate	NOUN
fnp-3806	2556	15	-	-	PUNCT
fnp-3806	2556	16	glutamine	glutamine	NOUN
fnp-3806	2556	17	and	and	CCONJ
fnp-3806	2556	18	gaba	gaba	PROPN
fnp-3806	2556	19	in	in	ADP
fnp-3806	2556	20	brain	brain	NOUN
fnp-3806	2556	21	of	of	ADP
fnp-3806	2556	22	normal	normal	ADJ
fnp-3806	2556	23	aged	aged	ADJ
fnp-3806	2556	24	and	and	CCONJ
fnp-3806	2556	25	patients	patient	NOUN
fnp-3806	2556	26	with	with	ADP
fnp-3806	2556	27	cognitive	cognitive	ADJ
fnp-3806	2556	28	impairment	impairment	NOUN
fnp-3806	2556	29	.	.	PUNCT
fnp-3806	2557	1	eur	eur	ADJ
fnp-3806	2557	2	radiol	radiol	NOUN
fnp-3806	2557	3	2017;27:2698	2017;27:2698	NUM
fnp-3806	2557	4	-	-	SYM
fnp-3806	2557	5	2705	2705	NUM
fnp-3806	2557	6	.	.	PUNCT
fnp-3806	2558	1	https://doi.org/10.1007/s00330-016-4669-8	https://doi.org/10.1007/s00330-016-4669-8	NUM
fnp-3806	2558	2	murari	murari	PROPN
fnp-3806	2558	3	g	g	PROPN
fnp-3806	2558	4	,	,	PUNCT
fnp-3806	2558	5	liang	liang	PROPN
fnp-3806	2558	6	dr	dr	PROPN
fnp-3806	2558	7	,	,	PUNCT
fnp-3806	2558	8	ali	ali	PROPN
fnp-3806	2558	9	a	a	PROPN
fnp-3806	2558	10	,	,	PUNCT
fnp-3806	2558	11	et	et	PROPN
fnp-3806	2558	12	al	al	PROPN
fnp-3806	2558	13	.	.	PROPN
fnp-3806	2558	14	prefrontal	prefrontal	PROPN
fnp-3806	2558	15	gaba	gaba	PROPN
fnp-3806	2558	16	levels	level	NOUN
fnp-3806	2558	17	correlate	correlate	VERB
fnp-3806	2558	18	with	with	ADP
fnp-3806	2558	19	memory	memory	NOUN
fnp-3806	2558	20	in	in	ADP
fnp-3806	2558	21	older	old	ADJ
fnp-3806	2558	22	adults	adult	NOUN
fnp-3806	2558	23	at	at	ADP
fnp-3806	2558	24	high	high	ADJ
fnp-3806	2558	25	risk	risk	NOUN
fnp-3806	2558	26	for	for	ADP
fnp-3806	2558	27	alzheimer	alzheimer	PROPN
fnp-3806	2558	28	's	's	PART
fnp-3806	2558	29	disease	disease	NOUN
fnp-3806	2558	30	.	.	PUNCT
fnp-3806	2559	1	cereb	cereb	PROPN
fnp-3806	2559	2	cortex	cortex	PROPN
fnp-3806	2559	3	commun	commun	PROPN
fnp-3806	2559	4	2020;1	2020;1	PROPN
fnp-3806	2559	5	:	:	PUNCT
fnp-3806	2559	6	tgaa022	tgaa022	PROPN
fnp-3806	2559	7	.	.	PUNCT
fnp-3806	2560	1	https://doi.org/10.1093/texcom/tgaa02	https://doi.org/10.1093/texcom/tgaa02	PROPN
fnp-3806	2560	2	liu	liu	PROPN
fnp-3806	2560	3	h	h	PROPN
fnp-3806	2560	4	,	,	PUNCT
fnp-3806	2560	5	zhang	zhang	PROPN
fnp-3806	2560	6	d	d	PROPN
fnp-3806	2560	7	,	,	PUNCT
fnp-3806	2560	8	lin	lin	PROPN
fnp-3806	2560	9	h	h	PROPN
fnp-3806	2560	10	,	,	PUNCT
fnp-3806	2560	11	et	et	PROPN
fnp-3806	2560	12	al	al	PROPN
fnp-3806	2560	13	.	.	PUNCT
fnp-3806	2561	1	meta	meta	VERB
fnp-3806	2561	2	-	-	PUNCT
fnp-3806	2561	3	analysis	analysis	NOUN
fnp-3806	2561	4	of	of	ADP
fnp-3806	2561	5	neurochemical	neurochemical	ADJ
fnp-3806	2561	6	changes	change	NOUN
fnp-3806	2561	7	estimated	estimate	VERB
fnp-3806	2561	8	via	via	ADP
fnp-3806	2561	9	magnetic	magnetic	ADJ
fnp-3806	2561	10	resonance	resonance	NOUN
fnp-3806	2561	11	spectroscopy	spectroscopy	NOUN
fnp-3806	2561	12	in	in	ADP
fnp-3806	2561	13	mild	mild	ADJ
fnp-3806	2561	14	cognitive	cognitive	ADJ
fnp-3806	2561	15	impairment	impairment	NOUN
fnp-3806	2561	16	and	and	CCONJ
fnp-3806	2561	17	alzheimer	alzheimer	NOUN
fnp-3806	2561	18	's	's	PART
fnp-3806	2561	19	disease	disease	NOUN
fnp-3806	2561	20	.	.	PUNCT
fnp-3806	2562	1	front	front	ADJ
fnp-3806	2562	2	aging	age	VERB
fnp-3806	2562	3	neurosci	neurosci	NOUN
fnp-3806	2562	4	2021;13:738971	2021;13:738971	NUM
fnp-3806	2562	5	.	.	PUNCT
fnp-3806	2563	1	https://doi.org/10.3389/fnagi.2021.738971	https://doi.org/10.3389/fnagi.2021.738971	PROPN
fnp-3806	2563	2	limon	limon	PROPN
fnp-3806	2563	3	a	a	PROPN
fnp-3806	2563	4	,	,	PUNCT
fnp-3806	2563	5	reyes	reyes	PROPN
fnp-3806	2563	6	-	-	PUNCT
fnp-3806	2563	7	ruiz	ruiz	PROPN
fnp-3806	2563	8	jm	jm	PROPN
fnp-3806	2563	9	,	,	PUNCT
fnp-3806	2563	10	miledi	miledi	PROPN
fnp-3806	2563	11	r.	r.	PROPN
fnp-3806	2563	12	loss	loss	PROPN
fnp-3806	2563	13	of	of	ADP
fnp-3806	2563	14	functional	functional	ADJ
fnp-3806	2563	15	gaba(a	gaba(a	NOUN
fnp-3806	2563	16	)	)	PUNCT
fnp-3806	2563	17	receptors	receptor	NOUN
fnp-3806	2563	18	in	in	ADP
fnp-3806	2563	19	the	the	DET
fnp-3806	2563	20	alzheimer	alzheimer	ADJ
fnp-3806	2563	21	diseased	disease	VERB
fnp-3806	2563	22	brain	brain	NOUN
fnp-3806	2563	23	.	.	PUNCT
fnp-3806	2564	1	proc	proc	PROPN
fnp-3806	2564	2	natl	natl	PROPN
fnp-3806	2564	3	acad	acad	PROPN
fnp-3806	2564	4	sci	sci	PROPN
fnp-3806	2564	5	usa	usa	PROPN
fnp-3806	2564	6	2012;109:10071	2012;109:10071	NUM
fnp-3806	2564	7	-	-	SYM
fnp-3806	2564	8	10076	10076	NUM
fnp-3806	2564	9	.	.	PUNCT
fnp-3806	2565	1	https://doi.org/10.1073/pnas.1204606109	https://doi.org/10.1073/pnas.1204606109	VERB
fnp-3806	2565	2	mizukami	mizukami	PROPN
fnp-3806	2565	3	k	k	PROPN
fnp-3806	2565	4	,	,	PUNCT
fnp-3806	2565	5	ikonomovic	ikonomovic	PROPN
fnp-3806	2565	6	md	md	PROPN
fnp-3806	2565	7	,	,	PUNCT
fnp-3806	2565	8	grayson	grayson	PROPN
fnp-3806	2565	9	dr	dr	PROPN
fnp-3806	2565	10	,	,	PUNCT
fnp-3806	2565	11	et	et	PROPN
fnp-3806	2565	12	al	al	PROPN
fnp-3806	2565	13	.	.	PUNCT
fnp-3806	2566	1	immunohistochemical	immunohistochemical	ADJ
fnp-3806	2566	2	study	study	NOUN
fnp-3806	2566	3	of	of	ADP
fnp-3806	2566	4	gabaa	gabaa	PROPN
fnp-3806	2566	5	receptor	receptor	NOUN
fnp-3806	2566	6	alpha1	alpha1	NOUN
fnp-3806	2566	7	subunit	subunit	NOUN
fnp-3806	2566	8	in	in	ADP
fnp-3806	2566	9	the	the	DET
fnp-3806	2566	10	hippocampal	hippocampal	ADJ
fnp-3806	2566	11	formation	formation	NOUN
fnp-3806	2566	12	of	of	ADP
fnp-3806	2566	13	aged	aged	ADJ
fnp-3806	2566	14	brains	brain	NOUN
fnp-3806	2566	15	with	with	ADP
fnp-3806	2566	16	alzheimer	alzheimer	NOUN
fnp-3806	2566	17	-	-	PUNCT
fnp-3806	2566	18	related	relate	VERB
fnp-3806	2566	19	neuropathologic	neuropathologic	ADJ
fnp-3806	2566	20	changes	change	NOUN
fnp-3806	2566	21	.	.	PUNCT
fnp-3806	2567	1	brain	brain	NOUN
fnp-3806	2567	2	res	re	NOUN
fnp-3806	2567	3	1998;799:148	1998;799:148	NUM
fnp-3806	2567	4	-	-	SYM
fnp-3806	2567	5	155	155	NUM
fnp-3806	2567	6	.	.	PUNCT
fnp-3806	2568	1	https://doi.org/10.1016/s0006-8993(98)00437-5	https://doi.org/10.1016/s0006-8993(98)00437-5	PROPN
fnp-3806	2568	2	rissman	rissman	PROPN
fnp-3806	2568	3	ra	ra	PROPN
fnp-3806	2568	4	,	,	PUNCT
fnp-3806	2568	5	mishizen	mishizen	PROPN
fnp-3806	2568	6	-	-	PUNCT
fnp-3806	2568	7	eberz	eberz	NOUN
fnp-3806	2568	8	aj	aj	PROPN
fnp-3806	2568	9	,	,	PUNCT
fnp-3806	2568	10	carter	carter	PROPN
fnp-3806	2568	11	tl	tl	PROPN
fnp-3806	2568	12	,	,	PUNCT
fnp-3806	2568	13	et	et	PROPN
fnp-3806	2568	14	al	al	PROPN
fnp-3806	2568	15	.	.	PUNCT
fnp-3806	2569	1	biochemical	biochemical	ADJ
fnp-3806	2569	2	analysis	analysis	NOUN
fnp-3806	2569	3	of	of	ADP
fnp-3806	2569	4	gaba(a	gaba(a	NOUN
fnp-3806	2569	5	)	)	PUNCT
fnp-3806	2569	6	receptor	receptor	NOUN
fnp-3806	2569	7	subunits	subunit	NOUN
fnp-3806	2569	8	alpha	alpha	NOUN
fnp-3806	2569	9	1	1	NUM
fnp-3806	2569	10	,	,	PUNCT
fnp-3806	2569	11	alpha	alpha	NOUN
fnp-3806	2569	12	5	5	NUM
fnp-3806	2569	13	,	,	PUNCT
fnp-3806	2569	14	beta	beta	NOUN
fnp-3806	2569	15	1	1	NUM
fnp-3806	2569	16	,	,	PUNCT
fnp-3806	2569	17	beta	beta	NOUN
fnp-3806	2569	18	2	2	NUM
fnp-3806	2569	19	in	in	ADP
fnp-3806	2569	20	the	the	DET
fnp-3806	2569	21	hippocampus	hippocampus	NOUN
fnp-3806	2569	22	of	of	ADP
fnp-3806	2569	23	patients	patient	NOUN
fnp-3806	2569	24	with	with	ADP
fnp-3806	2569	25	alzheimer	alzheimer	PROPN
fnp-3806	2569	26	's	's	PART
fnp-3806	2569	27	disease	disease	NOUN
fnp-3806	2569	28	neuropathology	neuropathology	NOUN
fnp-3806	2569	29	.	.	PUNCT
fnp-3806	2570	1	neuroscience	neuroscience	NOUN
fnp-3806	2570	2	2003;120:695	2003;120:695	NUM
fnp-3806	2570	3	-	-	SYM
fnp-3806	2570	4	704	704	NUM
fnp-3806	2570	5	.	.	PUNCT
fnp-3806	2571	1	https://doi.org/10.1016/s0306-4522(03)00030-7	https://doi.org/10.1016/s0306-4522(03)00030-7	PROPN
fnp-3806	2571	2	rissman	rissman	PROPN
fnp-3806	2571	3	ra	ra	PROPN
fnp-3806	2571	4	,	,	PUNCT
fnp-3806	2571	5	bennett	bennett	PROPN
fnp-3806	2571	6	da	da	PROPN
fnp-3806	2571	7	,	,	PUNCT
fnp-3806	2572	1	armstrong	armstrong	PROPN
fnp-3806	2572	2	dm	dm	PROPN
fnp-3806	2572	3	.	.	PUNCT
fnp-3806	2572	4	subregional	subregional	ADJ
fnp-3806	2572	5	analysis	analysis	NOUN
fnp-3806	2572	6	of	of	ADP
fnp-3806	2572	7	gaba(a	gaba(a	NOUN
fnp-3806	2572	8	)	)	PUNCT
fnp-3806	2572	9	receptor	receptor	NOUN
fnp-3806	2572	10	subunit	subunit	NOUN
fnp-3806	2572	11	mrnas	mrna	NOUN
fnp-3806	2572	12	in	in	ADP
fnp-3806	2572	13	the	the	DET
fnp-3806	2572	14	hippocampus	hippocampus	NOUN
fnp-3806	2572	15	of	of	ADP
fnp-3806	2572	16	older	old	ADJ
fnp-3806	2572	17	persons	person	NOUN
fnp-3806	2572	18	with	with	ADP
fnp-3806	2572	19	and	and	CCONJ
fnp-3806	2572	20	without	without	ADP
fnp-3806	2572	21	cognitive	cognitive	ADJ
fnp-3806	2572	22	impairment	impairment	NOUN
fnp-3806	2572	23	.	.	PUNCT
fnp-3806	2573	1	j	j	PROPN
fnp-3806	2573	2	chem	chem	PROPN
fnp-3806	2573	3	neuroanat	neuroanat	PROPN
fnp-3806	2573	4	2004;28:17	2004;28:17	PROPN
fnp-3806	2573	5	-	-	SYM
fnp-3806	2573	6	25	25	NUM
fnp-3806	2573	7	.	.	PUNCT
fnp-3806	2574	1	https://doi.org/10.1016/j.jchemneu.2004.05.003	https://doi.org/10.1016/j.jchemneu.2004.05.003	PROPN
fnp-3806	2574	2	iwakiri	iwakiri	PROPN
fnp-3806	2574	3	m	m	PROPN
fnp-3806	2574	4	,	,	PUNCT
fnp-3806	2574	5	mizukami	mizukami	PROPN
fnp-3806	2574	6	k	k	NOUN
fnp-3806	2574	7	,	,	PUNCT
fnp-3806	2574	8	ikonomovic	ikonomovic	PROPN
fnp-3806	2574	9	dm	dm	PROPN
fnp-3806	2574	10	,	,	PUNCT
fnp-3806	2574	11	et	et	PROPN
fnp-3806	2574	12	al	al	PROPN
fnp-3806	2574	13	.	.	PUNCT
fnp-3806	2575	1	an	an	DET
fnp-3806	2575	2	immunohistochemical	immunohistochemical	ADJ
fnp-3806	2575	3	study	study	NOUN
fnp-3806	2575	4	of	of	ADP
fnp-3806	2575	5	gaba	gaba	PROPN
fnp-3806	2575	6	a	a	DET
fnp-3806	2575	7	receptor	receptor	NOUN
fnp-3806	2575	8	gammasubunits	gammasubunit	NOUN
fnp-3806	2575	9	in	in	ADP
fnp-3806	2575	10	alzheimer	alzheimer	PROPN
fnp-3806	2575	11	's	's	PART
fnp-3806	2575	12	disease	disease	NOUN
fnp-3806	2575	13	hippocampus	hippocampus	NOUN
fnp-3806	2575	14	:	:	PUNCT
fnp-3806	2575	15	relationship	relationship	NOUN
fnp-3806	2575	16	to	to	ADP
fnp-3806	2575	17	neurofibrillary	neurofibrillary	ADJ
fnp-3806	2575	18	tangle	tangle	NOUN
fnp-3806	2575	19	progression	progression	NOUN
fnp-3806	2575	20	.	.	PUNCT
fnp-3806	2576	1	neuropathology	neuropathology	NOUN
fnp-3806	2576	2	2009;29:263	2009;29:263	PROPN
fnp-3806	2576	3	-	-	SYM
fnp-3806	2576	4	269	269	NUM
fnp-3806	2576	5	.	.	PUNCT
fnp-3806	2577	1	https://doi.org/10.1111/j.1440-1789.2008.00978.x	https://doi.org/10.1111/j.1440-1789.2008.00978.x	PROPN
fnp-3806	2577	2	mizukami	mizukami	PROPN
fnp-3806	2577	3	k	k	PROPN
fnp-3806	2577	4	,	,	PUNCT
fnp-3806	2577	5	ikonomovic	ikonomovic	PROPN
fnp-3806	2577	6	md	md	PROPN
fnp-3806	2577	7	,	,	PUNCT
fnp-3806	2577	8	grayson	grayson	PROPN
fnp-3806	2577	9	dr	dr	PROPN
fnp-3806	2577	10	,	,	PUNCT
fnp-3806	2577	11	et	et	PROPN
fnp-3806	2577	12	al	al	PROPN
fnp-3806	2577	13	.	.	PUNCT
fnp-3806	2578	1	immunohistochemical	immunohistochemical	ADJ
fnp-3806	2578	2	study	study	NOUN
fnp-3806	2578	3	of	of	ADP
fnp-3806	2578	4	gaba(a	gaba(a	PROPN
fnp-3806	2578	5	)	)	PUNCT
fnp-3806	2578	6	receptor	receptor	NOUN
fnp-3806	2578	7	beta2/3	beta2/3	PROPN
fnp-3806	2578	8	subunits	subunit	NOUN
fnp-3806	2578	9	in	in	ADP
fnp-3806	2578	10	the	the	DET
fnp-3806	2578	11	hippocampal	hippocampal	ADJ
fnp-3806	2578	12	formation	formation	NOUN
fnp-3806	2578	13	of	of	ADP
fnp-3806	2578	14	aged	aged	ADJ
fnp-3806	2578	15	brains	brain	NOUN
fnp-3806	2578	16	with	with	ADP
fnp-3806	2578	17	alzheimer	alzheimer	NOUN
fnp-3806	2578	18	-	-	PUNCT
fnp-3806	2578	19	related	relate	VERB
fnp-3806	2578	20	neuropathologic	neuropathologic	ADJ
fnp-3806	2578	21	changes	change	NOUN
fnp-3806	2578	22	.	.	PUNCT
fnp-3806	2579	1	exp	exp	NOUN
fnp-3806	2579	2	neurol	neurol	PROPN
fnp-3806	2579	3	1997;147:333	1997;147:333	NUM
fnp-3806	2579	4	-	-	SYM
fnp-3806	2579	5	345	345	NUM
fnp-3806	2579	6	.	.	PUNCT
fnp-3806	2580	1	https://doi.org/10.1006/exnr.1997.6591	https://doi.org/10.1006/exnr.1997.6591	PROPN
fnp-3806	2580	2	kwakowsky	kwakowsky	PROPN
fnp-3806	2580	3	a	a	PROPN
fnp-3806	2580	4	,	,	PUNCT
fnp-3806	2580	5	calvo	calvo	NOUN
fnp-3806	2580	6	-	-	PUNCT
fnp-3806	2580	7	flores	flores	PROPN
fnp-3806	2580	8	guzmán	guzmán	PROPN
fnp-3806	2580	9	b	b	PROPN
fnp-3806	2580	10	,	,	PUNCT
fnp-3806	2580	11	pandya	pandya	PROPN
fnp-3806	2580	12	m	m	PROPN
fnp-3806	2580	13	,	,	PUNCT
fnp-3806	2580	14	et	et	PROPN
fnp-3806	2580	15	al	al	PROPN
fnp-3806	2580	16	.	.	PUNCT
fnp-3806	2580	17	gabaa	gabaa	PROPN
fnp-3806	2580	18	receptor	receptor	NOUN
fnp-3806	2580	19	subunit	subunit	NOUN
fnp-3806	2580	20	expression	expression	NOUN
fnp-3806	2580	21	changes	change	NOUN
fnp-3806	2580	22	in	in	ADP
fnp-3806	2580	23	the	the	DET
fnp-3806	2580	24	human	human	PROPN
fnp-3806	2580	25	alzheimer	alzheimer	PROPN
fnp-3806	2580	26	's	's	PART
fnp-3806	2580	27	disease	disease	NOUN
fnp-3806	2580	28	hippocampus	hippocampus	NOUN
fnp-3806	2580	29	,	,	PUNCT
fnp-3806	2580	30	subiculum	subiculum	NOUN
fnp-3806	2580	31	,	,	PUNCT
fnp-3806	2580	32	entorhinal	entorhinal	ADJ
fnp-3806	2580	33	cortex	cortex	NOUN
fnp-3806	2580	34	and	and	CCONJ
fnp-3806	2580	35	superior	superior	ADJ
fnp-3806	2580	36	temporal	temporal	ADJ
fnp-3806	2580	37	gyrus	gyru	NOUN
fnp-3806	2580	38	.	.	PUNCT
fnp-3806	2581	1	j	j	PROPN
fnp-3806	2581	2	neurochem	neurochem	PROPN
fnp-3806	2581	3	2018;145:374	2018;145:374	NUM
fnp-3806	2581	4	-	-	SYM
fnp-3806	2581	5	392	392	NUM
fnp-3806	2581	6	.	.	PUNCT
fnp-3806	2582	1	https://doi.org/10.1111/jnc.14325	https://doi.org/10.1111/jnc.14325	PROPN
fnp-3806	2582	2	villette	villette	PROPN
fnp-3806	2582	3	v	v	PROPN
fnp-3806	2582	4	,	,	PUNCT
fnp-3806	2582	5	poindessous	poindessous	ADJ
fnp-3806	2582	6	-	-	PUNCT
fnp-3806	2582	7	jaza	jaza	NOUN
fnp-3806	2582	8	f	f	PROPN
fnp-3806	2582	9	,	,	PUNCT
fnp-3806	2582	10	simon	simon	PROPN
fnp-3806	2582	11	a	a	PROPN
fnp-3806	2582	12	,	,	PUNCT
fnp-3806	2582	13	et	et	PROPN
fnp-3806	2582	14	al	al	PROPN
fnp-3806	2582	15	.	.	PROPN
fnp-3806	2582	16	decreased	decrease	VERB
fnp-3806	2582	17	rhythmic	rhythmic	ADJ
fnp-3806	2582	18	gabaergic	gabaergic	ADJ
fnp-3806	2582	19	septal	septal	ADJ
fnp-3806	2582	20	activity	activity	NOUN
fnp-3806	2582	21	and	and	CCONJ
fnp-3806	2582	22	memory	memory	NOUN
fnp-3806	2582	23	-	-	PUNCT
fnp-3806	2582	24	associated	associate	VERB
fnp-3806	2582	25	theta	theta	NOUN
fnp-3806	2582	26	oscillations	oscillation	NOUN
fnp-3806	2582	27	after	after	ADP
fnp-3806	2582	28	hippocampal	hippocampal	ADJ
fnp-3806	2582	29	amyloid	amyloid	NOUN
fnp-3806	2582	30	-	-	PUNCT
fnp-3806	2582	31	beta	beta	NOUN
fnp-3806	2582	32	pathology	pathology	NOUN
fnp-3806	2582	33	in	in	ADP
fnp-3806	2582	34	the	the	DET
fnp-3806	2582	35	rat	rat	NOUN
fnp-3806	2582	36	.	.	PROPN
fnp-3806	2583	1	j	j	PROPN
fnp-3806	2583	2	neurosci	neurosci	PROPN
fnp-3806	2583	3	2010;30:10991	2010;30:10991	NUM
fnp-3806	2583	4	-	-	SYM
fnp-3806	2583	5	11003	11003	NUM
fnp-3806	2583	6	.	.	PUNCT
fnp-3806	2584	1	https://doi.org/10.1523/jneurosci.6284-09.2010	https://doi.org/10.1523/jneurosci.6284-09.2010	NOUN
fnp-3806	2584	2	verret	verret	PROPN
fnp-3806	2584	3	l	l	PROPN
fnp-3806	2584	4	,	,	PUNCT
fnp-3806	2584	5	mann	mann	PROPN
fnp-3806	2584	6	eo	eo	PROPN
fnp-3806	2584	7	,	,	PUNCT
fnp-3806	2584	8	hang	hang	VERB
fnp-3806	2584	9	gb	gb	PRON
fnp-3806	2584	10	,	,	PUNCT
fnp-3806	2584	11	et	et	PROPN
fnp-3806	2584	12	al	al	PROPN
fnp-3806	2584	13	.	.	PROPN
fnp-3806	2585	1	inhibitory	inhibitory	ADJ
fnp-3806	2585	2	interneuron	interneuron	NOUN
fnp-3806	2585	3	deficit	deficit	NOUN
fnp-3806	2585	4	links	link	NOUN
fnp-3806	2585	5	altered	alter	VERB
fnp-3806	2585	6	network	network	NOUN
fnp-3806	2585	7	activity	activity	NOUN
fnp-3806	2585	8	and	and	CCONJ
fnp-3806	2585	9	cognitive	cognitive	ADJ
fnp-3806	2585	10	dysfunction	dysfunction	NOUN
fnp-3806	2585	11	in	in	ADP
fnp-3806	2585	12	alzheimer	alzheimer	PROPN
fnp-3806	2585	13	model	model	PROPN
fnp-3806	2585	14	.	.	PUNCT
fnp-3806	2586	1	cell	cell	NOUN
fnp-3806	2586	2	2012;149:708	2012;149:708	NUM
fnp-3806	2586	3	-	-	SYM
fnp-3806	2586	4	721	721	NUM
fnp-3806	2586	5	.	.	PUNCT
fnp-3806	2587	1	https://doi.org/10.1016/j.cell.2012.02.046	https://doi.org/10.1016/j.cell.2012.02.046	PROPN
fnp-3806	2587	2	ulrich	ulrich	PROPN
fnp-3806	2587	3	d.	d.	PROPN
fnp-3806	2587	4	amyloid	amyloid	NOUN
fnp-3806	2587	5	-	-	PUNCT
fnp-3806	2587	6	beta	beta	NOUN
fnp-3806	2587	7	impairs	impair	VERB
fnp-3806	2587	8	synaptic	synaptic	ADJ
fnp-3806	2587	9	inhibition	inhibition	NOUN
fnp-3806	2587	10	via	via	ADP
fnp-3806	2587	11	gaba(a	gaba(a	NOUN
fnp-3806	2587	12	)	)	PUNCT
fnp-3806	2587	13	receptor	receptor	NOUN
fnp-3806	2587	14	endocytosis	endocytosis	NOUN
fnp-3806	2587	15	.	.	PUNCT
fnp-3806	2588	1	j	j	PROPN
fnp-3806	2588	2	neurosci	neurosci	PROPN
fnp-3806	2588	3	2015;35	2015;35	NUM
fnp-3806	2588	4	:	:	PUNCT
fnp-3806	2588	5	9205	9205	NUM
fnp-3806	2588	6	-	-	SYM
fnp-3806	2588	7	9210	9210	NUM
fnp-3806	2588	8	.	.	PUNCT
fnp-3806	2589	1	https://doi.org/10.1523/jneurosci.0950-15.2015	https://doi.org/10.1523/jneurosci.0950-15.2015	PROPN
fnp-3806	2589	2	hamm	hamm	PROPN
fnp-3806	2589	3	v	v	PROPN
fnp-3806	2589	4	,	,	PUNCT
fnp-3806	2589	5	héraud	héraud	ADV
fnp-3806	2589	6	c	c	NOUN
fnp-3806	2589	7	,	,	PUNCT
fnp-3806	2589	8	bott	bott	PROPN
fnp-3806	2589	9	jb	jb	PROPN
fnp-3806	2589	10	,	,	PUNCT
fnp-3806	2589	11	et	et	PROPN
fnp-3806	2589	12	al	al	PROPN
fnp-3806	2589	13	.	.	PROPN
fnp-3806	2589	14	differential	differential	PROPN
fnp-3806	2589	15	contribution	contribution	NOUN
fnp-3806	2589	16	of	of	ADP
fnp-3806	2589	17	app	app	NOUN
fnp-3806	2589	18	metabolites	metabolite	NOUN
fnp-3806	2589	19	to	to	ADP
fnp-3806	2589	20	early	early	ADJ
fnp-3806	2589	21	cognitive	cognitive	ADJ
fnp-3806	2589	22	deficits	deficit	NOUN
fnp-3806	2589	23	in	in	ADP
fnp-3806	2589	24	a	a	DET
fnp-3806	2589	25	tgcrnd8	tgcrnd8	PROPN
fnp-3806	2589	26	mouse	mouse	NOUN
fnp-3806	2589	27	model	model	NOUN
fnp-3806	2589	28	of	of	ADP
fnp-3806	2589	29	alzheimer	alzheimer	PROPN
fnp-3806	2589	30	's	's	PART
fnp-3806	2589	31	disease	disease	NOUN
fnp-3806	2589	32	.	.	PUNCT
fnp-3806	2590	1	sci	sci	PROPN
fnp-3806	2590	2	adv	adv	PROPN
fnp-3806	2590	3	2017;3	2017;3	NUM
fnp-3806	2590	4	:	:	PUNCT
fnp-3806	2590	5	e1601068	e1601068	VERB
fnp-3806	2590	6	.	.	PUNCT
fnp-3806	2591	1	https://doi.org/10.1126/sciadv.1601068	https://doi.org/10.1126/sciadv.1601068	PROPN
fnp-3806	2591	2	palop	palop	PROPN
fnp-3806	2591	3	jj	jj	PROPN
fnp-3806	2591	4	,	,	PUNCT
fnp-3806	2591	5	chin	chin	PROPN
fnp-3806	2591	6	j	j	PROPN
fnp-3806	2591	7	,	,	PUNCT
fnp-3806	2591	8	roberson	roberson	PROPN
fnp-3806	2591	9	ed	ed	PROPN
fnp-3806	2591	10	,	,	PUNCT
fnp-3806	2591	11	et	et	PROPN
fnp-3806	2591	12	al	al	PROPN
fnp-3806	2591	13	.	.	PROPN
fnp-3806	2592	1	aberrant	aberrant	ADJ
fnp-3806	2592	2	excitatory	excitatory	ADJ
fnp-3806	2592	3	neuronal	neuronal	ADJ
fnp-3806	2592	4	activity	activity	NOUN
fnp-3806	2592	5	and	and	CCONJ
fnp-3806	2592	6	compensatory	compensatory	NOUN
fnp-3806	2592	7	remodelling	remodelling	NOUN
fnp-3806	2592	8	of	of	ADP
fnp-3806	2592	9	inhibitory	inhibitory	ADJ
fnp-3806	2592	10	hippocampal	hippocampal	ADJ
fnp-3806	2592	11	circuits	circuit	NOUN
fnp-3806	2592	12	in	in	ADP
fnp-3806	2592	13	mouse	mouse	NOUN
fnp-3806	2592	14	models	model	NOUN
fnp-3806	2592	15	of	of	ADP
fnp-3806	2592	16	alzheimer	alzheimer	PROPN
fnp-3806	2592	17	's	's	PART
fnp-3806	2592	18	disease	disease	NOUN
fnp-3806	2592	19	.	.	PUNCT
fnp-3806	2593	1	neuron	neuron	PROPN
fnp-3806	2593	2	2007;55:697	2007;55:697	ADV
fnp-3806	2593	3	-	-	SYM
fnp-3806	2593	4	711	711	NUM
fnp-3806	2593	5	.	.	PUNCT
fnp-3806	2594	1	https://doi.org/10.1016/j.neuron.2007.07.025	https://doi.org/10.1016/j.neuron.2007.07.025	ADJ
fnp-3806	2594	2	hoyer	hoyer	PROPN
fnp-3806	2594	3	d	d	PROPN
fnp-3806	2594	4	,	,	PUNCT
fnp-3806	2594	5	martin	martin	PROPN
fnp-3806	2594	6	g.	g.	PROPN
fnp-3806	2594	7	5	5	NUM
fnp-3806	2594	8	-	-	PUNCT
fnp-3806	2594	9	ht	ht	PROPN
fnp-3806	2594	10	receptor	receptor	NOUN
fnp-3806	2594	11	classification	classification	NOUN
fnp-3806	2594	12	and	and	CCONJ
fnp-3806	2594	13	nomenclature	nomenclature	NOUN
fnp-3806	2594	14	:	:	PUNCT
fnp-3806	2594	15	towards	towards	ADP
fnp-3806	2594	16	a	a	DET
fnp-3806	2594	17	harmonization	harmonization	NOUN
fnp-3806	2594	18	with	with	ADP
fnp-3806	2594	19	the	the	DET
fnp-3806	2594	20	human	human	ADJ
fnp-3806	2594	21	genome	genome	NOUN
fnp-3806	2594	22	.	.	PUNCT
fnp-3806	2595	1	neuropharmacology	neuropharmacology	NOUN
fnp-3806	2595	2	1997;36:419	1997;36:419	PROPN
fnp-3806	2595	3	-	-	PUNCT
fnp-3806	2595	4	428	428	NUM
fnp-3806	2595	5	.	.	PUNCT
fnp-3806	2596	1	https://doi.org/10.1016/s0028-3908(97)00036-1	https://doi.org/10.1016/s0028-3908(97)00036-1	NOUN
fnp-3806	2596	2	barnes	barnes	PROPN
fnp-3806	2596	3	nm	nm	PROPN
fnp-3806	2596	4	,	,	PUNCT
fnp-3806	2596	5	sharp	sharp	PROPN
fnp-3806	2596	6	t.	t.	PROPN
fnp-3806	2596	7	a	a	DET
fnp-3806	2596	8	review	review	NOUN
fnp-3806	2596	9	of	of	ADP
fnp-3806	2596	10	central	central	ADJ
fnp-3806	2596	11	5	5	NUM
fnp-3806	2596	12	-	-	PUNCT
fnp-3806	2596	13	ht	ht	NOUN
fnp-3806	2596	14	receptors	receptor	NOUN
fnp-3806	2596	15	and	and	CCONJ
fnp-3806	2596	16	their	their	PRON
fnp-3806	2596	17	function	function	NOUN
fnp-3806	2596	18	.	.	PUNCT
fnp-3806	2597	1	neuropharmacology	neuropharmacology	NOUN
fnp-3806	2597	2	1999;38:1083	1999;38:1083	NUM
fnp-3806	2597	3	-	-	PUNCT
fnp-3806	2597	4	1152	1152	NUM
fnp-3806	2597	5	.	.	PUNCT
fnp-3806	2598	1	https:/	https:/	PROPN
fnp-3806	2598	2	doi.org/10.1016/s0028-3908(99)00010-6	doi.org/10.1016/s0028-3908(99)00010-6	PROPN
fnp-3806	2598	3	.	.	PUNCT
fnp-3806	2599	1	leysen	leysen	PROPN
fnp-3806	2599	2	je	je	PROPN
fnp-3806	2599	3	.	.	PROPN
fnp-3806	2600	1	5	5	NUM
fnp-3806	2600	2	-	-	PUNCT
fnp-3806	2600	3	ht2	ht2	NOUN
fnp-3806	2600	4	receptors	receptor	NOUN
fnp-3806	2600	5	.	.	PUNCT
fnp-3806	2601	1	curr	curr	PROPN
fnp-3806	2601	2	drug	drug	NOUN
fnp-3806	2601	3	targets	target	NOUN
fnp-3806	2601	4	-	-	PUNCT
fnp-3806	2601	5	cns	cns	NOUN
fnp-3806	2601	6	neurol	neurol	NOUN
fnp-3806	2601	7	disord	disord	PROPN
fnp-3806	2601	8	2004;3:11	2004;3:11	PROPN
fnp-3806	2601	9	-	-	PUNCT
fnp-3806	2601	10	26	26	NUM
fnp-3806	2601	11	.	.	PUNCT
fnp-3806	2602	1	https://doi.org/10.2174/1568007043482598	https://doi.org/10.2174/1568007043482598	PROPN
fnp-3806	2602	2	fink	fink	PROPN
fnp-3806	2602	3	kb	kb	PROPN
fnp-3806	2602	4	,	,	PUNCT
fnp-3806	2602	5	göthert	göthert	ADJ
fnp-3806	2602	6	m.	m.	NOUN
fnp-3806	2602	7	5	5	NUM
fnp-3806	2602	8	-	-	PUNCT
fnp-3806	2602	9	ht	ht	PROPN
fnp-3806	2602	10	receptor	receptor	NOUN
fnp-3806	2602	11	regulation	regulation	NOUN
fnp-3806	2602	12	of	of	ADP
fnp-3806	2602	13	neurotransmitter	neurotransmitter	NOUN
fnp-3806	2602	14	release	release	NOUN
fnp-3806	2602	15	.	.	PUNCT
fnp-3806	2603	1	pharmacol	pharmacol	PROPN
fnp-3806	2603	2	rev	rev	VERB
fnp-3806	2603	3	2007;59:360	2007;59:360	PROPN
fnp-3806	2603	4	-	-	SYM
fnp-3806	2603	5	417	417	NUM
fnp-3806	2603	6	.	.	PUNCT
fnp-3806	2604	1	https://doi.org/10.1124/pr.107.07103	https://doi.org/10.1124/pr.107.07103	X
fnp-3806	2604	2	nichols	nichols	PROPN
fnp-3806	2604	3	de	de	PROPN
fnp-3806	2604	4	,	,	PUNCT
fnp-3806	2604	5	nichols	nichols	PROPN
fnp-3806	2604	6	cd	cd	PROPN
fnp-3806	2604	7	.	.	PROPN
fnp-3806	2604	8	serotonin	serotonin	NOUN
fnp-3806	2604	9	receptors	receptor	NOUN
fnp-3806	2604	10	.	.	PUNCT
fnp-3806	2605	1	chem	chem	PROPN
fnp-3806	2605	2	rev	rev	VERB
fnp-3806	2605	3	2008;108:1614	2008;108:1614	NUM
fnp-3806	2605	4	-	-	SYM
fnp-3806	2605	5	1641	1641	NUM
fnp-3806	2605	6	.	.	PUNCT
fnp-3806	2606	1	https://doi.org/10.1021/cr078224o	https://doi.org/10.1021/cr078224o	PROPN
fnp-3806	2606	2	barnes	barne	VERB
fnp-3806	2606	3	nm	nm	PROPN
fnp-3806	2606	4	,	,	PUNCT
fnp-3806	2606	5	hales	hales	PROPN
fnp-3806	2606	6	tg	tg	PROPN
fnp-3806	2606	7	,	,	PUNCT
fnp-3806	2606	8	lummis	lummis	PROPN
fnp-3806	2606	9	sc	sc	PROPN
fnp-3806	2606	10	,	,	PUNCT
fnp-3806	2606	11	peters	peters	PROPN
fnp-3806	2606	12	ja	ja	PROPN
fnp-3806	2606	13	.	.	PUNCT
fnp-3806	2607	1	the	the	DET
fnp-3806	2607	2	5	5	NUM
fnp-3806	2607	3	-	-	PUNCT
fnp-3806	2607	4	ht3	ht3	NOUN
fnp-3806	2607	5	receptor	receptor	NOUN
fnp-3806	2607	6	:	:	PUNCT
fnp-3806	2607	7	the	the	DET
fnp-3806	2607	8	relationship	relationship	NOUN
fnp-3806	2607	9	between	between	ADP
fnp-3806	2607	10	structure	structure	NOUN
fnp-3806	2607	11	and	and	CCONJ
fnp-3806	2607	12	function	function	NOUN
fnp-3806	2607	13	.	.	PUNCT
fnp-3806	2608	1	neuropharmacology	neuropharmacology	NOUN
fnp-3806	2608	2	2009;56:273	2009;56:273	PROPN
fnp-3806	2608	3	-	-	PUNCT
fnp-3806	2608	4	284	284	NUM
fnp-3806	2608	5	.	.	PUNCT
fnp-3806	2609	1	https://doi.org/10.1016/j.neuropharm.2008.08.003	https://doi.org/10.1016/j.neuropharm.2008.08.003	NOUN
fnp-3806	2609	2	berumen	beruman	NOUN
fnp-3806	2609	3	lc	lc	PROPN
fnp-3806	2609	4	,	,	PUNCT
fnp-3806	2609	5	rodríguez	rodríguez	VERB
fnp-3806	2609	6	a	a	PRON
fnp-3806	2609	7	,	,	PUNCT
fnp-3806	2609	8	miledi	miledi	PROPN
fnp-3806	2609	9	r	r	NOUN
fnp-3806	2609	10	,	,	PUNCT
fnp-3806	2609	11	et	et	PROPN
fnp-3806	2609	12	al	al	PROPN
fnp-3806	2609	13	.	.	PROPN
fnp-3806	2609	14	serotonin	serotonin	VERB
fnp-3806	2609	15	receptors	receptor	NOUN
fnp-3806	2609	16	in	in	ADP
fnp-3806	2609	17	hippocampus	hippocampus	NOUN
fnp-3806	2609	18	.	.	PUNCT
fnp-3806	2610	1	sci	sci	PROPN
fnp-3806	2610	2	world	world	PROPN
fnp-3806	2610	3	j	j	PROPN
fnp-3806	2610	4	2012	2012	NUM
fnp-3806	2610	5	;	;	PUNCT
fnp-3806	2610	6	2012:823493	2012:823493	NUM
fnp-3806	2610	7	.	.	PUNCT
fnp-3806	2611	1	https://doi.org/10.1100/2012/823493	https://doi.org/10.1100/2012/823493	ADJ
fnp-3806	2611	2	palacios	palacio	NOUN
fnp-3806	2611	3	jm	jm	PROPN
fnp-3806	2611	4	.	.	PROPN
fnp-3806	2611	5	serotonin	serotonin	NOUN
fnp-3806	2611	6	receptors	receptor	NOUN
fnp-3806	2611	7	in	in	ADP
fnp-3806	2611	8	brain	brain	NOUN
fnp-3806	2611	9	revisited	revisit	VERB
fnp-3806	2611	10	.	.	PUNCT
fnp-3806	2612	1	brain	brain	NOUN
fnp-3806	2612	2	res	re	NOUN
fnp-3806	2612	3	2016;1645:46	2016;1645:46	NUM
fnp-3806	2612	4	-	-	SYM
fnp-3806	2612	5	49	49	NUM
fnp-3806	2612	6	.	.	PUNCT
fnp-3806	2613	1	https://doi.org/10.1016/j.brainres.2015.12.042	https://doi.org/10.1016/j.brainres.2015.12.042	NOUN
fnp-3806	2613	2	wirth	wirth	VERB
fnp-3806	2613	3	a	a	PRON
fnp-3806	2613	4	,	,	PUNCT
fnp-3806	2613	5	holst	holst	NOUN
fnp-3806	2613	6	k	k	NOUN
fnp-3806	2613	7	,	,	PUNCT
fnp-3806	2613	8	ponimaskin	ponimaskin	PROPN
fnp-3806	2613	9	e.	e.	PROPN
fnp-3806	2614	1	how	how	SCONJ
fnp-3806	2614	2	serotonin	serotonin	VERB
fnp-3806	2614	3	receptors	receptor	NOUN
fnp-3806	2614	4	regulate	regulate	VERB
fnp-3806	2614	5	morphogenic	morphogenic	ADJ
fnp-3806	2614	6	signalling	signal	VERB
fnp-3806	2614	7	in	in	ADP
fnp-3806	2614	8	neurons	neuron	NOUN
fnp-3806	2614	9	.	.	PUNCT
fnp-3806	2615	1	prog	prog	PROPN
fnp-3806	2615	2	neurobiol	neurobiol	PROPN
fnp-3806	2615	3	2017;151:35	2017;151:35	NUM
fnp-3806	2615	4	-	-	SYM
fnp-3806	2615	5	56	56	NUM
fnp-3806	2615	6	.	.	PUNCT
fnp-3806	2616	1	https://doi.org/10.1016/j.pneurobio.2016.03.007	https://doi.org/10.1016/j.pneurobio.2016.03.007	PROPN
fnp-3806	2616	2	consolo	consolo	PROPN
fnp-3806	2616	3	s	s	PROPN
fnp-3806	2616	4	,	,	PUNCT
fnp-3806	2616	5	arnaboldi	arnaboldi	PROPN
fnp-3806	2616	6	s	s	PROPN
fnp-3806	2616	7	,	,	PUNCT
fnp-3806	2616	8	giorgi	giorgi	PROPN
fnp-3806	2616	9	s	s	PROPN
fnp-3806	2616	10	,	,	PUNCT
fnp-3806	2616	11	et	et	PROPN
fnp-3806	2616	12	al	al	PROPN
fnp-3806	2616	13	.	.	PROPN
fnp-3806	2617	1	5	5	NUM
fnp-3806	2617	2	-	-	PUNCT
fnp-3806	2617	3	ht4	ht4	NOUN
fnp-3806	2617	4	receptor	receptor	NOUN
fnp-3806	2617	5	stimulation	stimulation	NOUN
fnp-3806	2617	6	facilitates	facilitate	VERB
fnp-3806	2617	7	acetylcholine	acetylcholine	NOUN
fnp-3806	2617	8	release	release	NOUN
fnp-3806	2617	9	in	in	ADP
fnp-3806	2617	10	rat	rat	NOUN
fnp-3806	2617	11	frontal	frontal	ADJ
fnp-3806	2617	12	cortex	cortex	NOUN
fnp-3806	2617	13	.	.	PUNCT
fnp-3806	2618	1	neuroreport	neuroreport	NOUN
fnp-3806	2618	2	1994;5:1230	1994;5:1230	NUM
fnp-3806	2618	3	-	-	SYM
fnp-3806	2618	4	1232	1232	NUM
fnp-3806	2618	5	.	.	PUNCT
fnp-3806	2619	1	https://doi.org/10.1097/00001756-199406020-00018	https://doi.org/10.1097/00001756-199406020-00018	PROPN
fnp-3806	2619	2	woods	woods	PROPN
fnp-3806	2619	3	s	s	PROPN
fnp-3806	2619	4	,	,	PUNCT
fnp-3806	2619	5	clarke	clarke	PROPN
fnp-3806	2619	6	nn	nn	PROPN
fnp-3806	2619	7	,	,	PUNCT
fnp-3806	2619	8	layfield	layfield	NOUN
fnp-3806	2619	9	r	r	NOUN
fnp-3806	2619	10	,	,	PUNCT
fnp-3806	2619	11	et	et	PROPN
fnp-3806	2619	12	al	al	PROPN
fnp-3806	2619	13	.	.	PROPN
fnp-3806	2620	1	5	5	NUM
fnp-3806	2620	2	-	-	SYM
fnp-3806	2620	3	ht	ht	X
fnp-3806	2620	4	(	(	PUNCT
fnp-3806	2620	5	6	6	NUM
fnp-3806	2620	6	)	)	PUNCT
fnp-3806	2620	7	receptor	receptor	NOUN
fnp-3806	2620	8	agonists	agonist	NOUN
fnp-3806	2620	9	and	and	CCONJ
fnp-3806	2620	10	antagonists	antagonist	NOUN
fnp-3806	2620	11	enhance	enhance	VERB
fnp-3806	2620	12	learning	learning	NOUN
fnp-3806	2620	13	and	and	CCONJ
fnp-3806	2620	14	memory	memory	NOUN
fnp-3806	2620	15	in	in	ADP
fnp-3806	2620	16	a	a	DET
fnp-3806	2620	17	conditioned	condition	VERB
fnp-3806	2620	18	emotion	emotion	NOUN
fnp-3806	2620	19	response	response	NOUN
fnp-3806	2620	20	paradigm	paradigm	NOUN
fnp-3806	2620	21	by	by	ADP
fnp-3806	2620	22	modulation	modulation	NOUN
fnp-3806	2620	23	of	of	ADP
fnp-3806	2620	24	cholinergic	cholinergic	ADJ
fnp-3806	2620	25	and	and	CCONJ
fnp-3806	2620	26	glutamatergic	glutamatergic	ADJ
fnp-3806	2620	27	mechanisms	mechanism	NOUN
fnp-3806	2620	28	.	.	PUNCT
fnp-3806	2621	1	br	br	PROPN
fnp-3806	2622	1	j	j	PROPN
fnp-3806	2622	2	pharmacol	pharmacol	PROPN
fnp-3806	2622	3	2012;167	2012;167	NUM
fnp-3806	2622	4	:	:	PUNCT
fnp-3806	2622	5	436	436	NUM
fnp-3806	2622	6	-	-	SYM
fnp-3806	2622	7	449	449	NUM
fnp-3806	2622	8	.	.	PUNCT
fnp-3806	2622	9	https://doi.org/10.1111/j.1476-5381.2012.02022.x	https://doi.org/10.1111/j.1476-5381.2012.02022.x	ADJ
fnp-3806	2622	10	seyedabadi	seyedabadi	PROPN
fnp-3806	2622	11	m	m	PROPN
fnp-3806	2622	12	,	,	PUNCT
fnp-3806	2622	13	fakhfouri	fakhfouri	PROPN
fnp-3806	2622	14	g	g	PROPN
fnp-3806	2622	15	,	,	PUNCT
fnp-3806	2622	16	ramezani	ramezani	PROPN
fnp-3806	2622	17	v	v	NOUN
fnp-3806	2622	18	,	,	PUNCT
fnp-3806	2622	19	et	et	PROPN
fnp-3806	2622	20	al	al	PROPN
fnp-3806	2622	21	.	.	PUNCT
fnp-3806	2623	1	the	the	DET
fnp-3806	2623	2	role	role	NOUN
fnp-3806	2623	3	of	of	ADP
fnp-3806	2623	4	serotonin	serotonin	NOUN
fnp-3806	2623	5	in	in	ADP
fnp-3806	2623	6	memory	memory	NOUN
fnp-3806	2623	7	:	:	PUNCT
fnp-3806	2623	8	interactions	interaction	NOUN
fnp-3806	2623	9	with	with	ADP
fnp-3806	2623	10	neurotransmitters	neurotransmitter	NOUN
fnp-3806	2623	11	and	and	CCONJ
fnp-3806	2623	12	downstream	downstream	ADJ
fnp-3806	2623	13	signaling	signaling	NOUN
fnp-3806	2623	14	.	.	PUNCT
fnp-3806	2624	1	exp	exp	NOUN
fnp-3806	2624	2	brain	brain	NOUN
fnp-3806	2624	3	res	re	NOUN
fnp-3806	2624	4	2014;232:723	2014;232:723	NUM
fnp-3806	2624	5	-	-	SYM
fnp-3806	2624	6	738	738	NUM
fnp-3806	2624	7	.	.	PUNCT
fnp-3806	2625	1	https://doi.org/10.1007/s00221-013-3818-4	https://doi.org/10.1007/s00221-013-3818-4	NUM
fnp-3806	2625	2	de	de	ADV
fnp-3806	2625	3	deurwaerdere	deurwaerdere	ADP
fnp-3806	2625	4	p	p	NOUN
fnp-3806	2625	5	,	,	PUNCT
fnp-3806	2625	6	di	di	X
fnp-3806	2625	7	giovanni	giovanni	PROPN
fnp-3806	2625	8	g.	g.	PROPN
fnp-3806	2625	9	5	5	NUM
fnp-3806	2625	10	-	-	PUNCT
fnp-3806	2625	11	ht	ht	NOUN
fnp-3806	2625	12	interaction	interaction	NOUN
fnp-3806	2625	13	with	with	ADP
fnp-3806	2625	14	other	other	ADJ
fnp-3806	2625	15	neurotransmitters	neurotransmitter	NOUN
fnp-3806	2625	16	:	:	PUNCT
fnp-3806	2625	17	an	an	DET
fnp-3806	2625	18	overview	overview	NOUN
fnp-3806	2625	19	.	.	PUNCT
fnp-3806	2626	1	prog	prog	NOUN
fnp-3806	2626	2	brain	brain	NOUN
fnp-3806	2626	3	res	re	NOUN
fnp-3806	2626	4	2021;259:1	2021;259:1	NOUN
fnp-3806	2626	5	-	-	SYM
fnp-3806	2626	6	5	5	NUM
fnp-3806	2626	7	.	.	PUNCT
fnp-3806	2627	1	https://doi.org/10.1016/bs.pbr.2021.01.001	https://doi.org/10.1016/bs.pbr.2021.01.001	PROPN
fnp-3806	2627	2	liu	liu	PROPN
fnp-3806	2627	3	rj	rj	PROPN
fnp-3806	2627	4	,	,	PUNCT
fnp-3806	2627	5	van	van	PROPN
fnp-3806	2627	6	den	den	PROPN
fnp-3806	2627	7	pol	pol	PROPN
fnp-3806	2627	8	an	an	PROPN
fnp-3806	2627	9	,	,	PUNCT
fnp-3806	2627	10	aghajanian	aghajanian	PROPN
fnp-3806	2627	11	gk	gk	PROPN
fnp-3806	2627	12	.	.	PROPN
fnp-3806	2627	13	hypocretins	hypocretins	PROPN
fnp-3806	2627	14	(	(	PUNCT
fnp-3806	2627	15	orexins	orexin	NOUN
fnp-3806	2627	16	)	)	PUNCT
fnp-3806	2627	17	regulate	regulate	VERB
fnp-3806	2627	18	serotonin	serotonin	NOUN
fnp-3806	2627	19	neurons	neuron	NOUN
fnp-3806	2627	20	in	in	ADP
fnp-3806	2627	21	the	the	DET
fnp-3806	2627	22	dorsal	dorsal	NOUN
fnp-3806	2627	23	raphe	raphe	NOUN
fnp-3806	2627	24	nucleus	nucleus	NOUN
fnp-3806	2627	25	by	by	ADP
fnp-3806	2627	26	excitatory	excitatory	NOUN
fnp-3806	2627	27	direct	direct	ADJ
fnp-3806	2627	28	and	and	CCONJ
fnp-3806	2627	29	inhibitory	inhibitory	ADJ
fnp-3806	2627	30	indirect	indirect	ADJ
fnp-3806	2627	31	actions	action	NOUN
fnp-3806	2627	32	.	.	PUNCT
fnp-3806	2628	1	j	j	PROPN
fnp-3806	2628	2	neurosci	neurosci	PROPN
fnp-3806	2628	3	2002;22:9453	2002;22:9453	NUM
fnp-3806	2628	4	-	-	SYM
fnp-3806	2628	5	9464	9464	NUM
fnp-3806	2628	6	.	.	PUNCT
fnp-3806	2629	1	https://doi.org/10.1523/jneurosci.22-21-09453.2002	https://doi.org/10.1523/jneurosci.22-21-09453.2002	NOUN
fnp-3806	2629	2	noristani	noristani	NOUN
fnp-3806	2629	3	hn	hn	PROPN
fnp-3806	2629	4	,	,	PUNCT
fnp-3806	2629	5	olabarria	olabarria	PROPN
fnp-3806	2629	6	m	m	PROPN
fnp-3806	2629	7	,	,	PUNCT
fnp-3806	2629	8	verkhratsky	verkhratsky	ADV
fnp-3806	2629	9	a	a	PRON
fnp-3806	2629	10	,	,	PUNCT
fnp-3806	2629	11	et	et	PROPN
fnp-3806	2629	12	al	al	PROPN
fnp-3806	2629	13	.	.	PROPN
fnp-3806	2629	14	serotonin	serotonin	NOUN
fnp-3806	2629	15	fibre	fibre	NOUN
fnp-3806	2629	16	sprouting	sprouting	NOUN
fnp-3806	2629	17	and	and	CCONJ
fnp-3806	2629	18	increase	increase	VERB
fnp-3806	2629	19	in	in	ADP
fnp-3806	2629	20	serotonin	serotonin	NOUN
fnp-3806	2629	21	transporter	transporter	NOUN
fnp-3806	2629	22	immunoreactivity	immunoreactivity	NOUN
fnp-3806	2629	23	in	in	ADP
fnp-3806	2629	24	the	the	DET
fnp-3806	2629	25	ca1	ca1	PROPN
fnp-3806	2629	26	area	area	NOUN
fnp-3806	2629	27	of	of	ADP
fnp-3806	2629	28	hippocampus	hippocampus	NOUN
fnp-3806	2629	29	in	in	ADP
fnp-3806	2629	30	a	a	DET
fnp-3806	2629	31	triple	triple	ADJ
fnp-3806	2629	32	transgenic	transgenic	NOUN
fnp-3806	2629	33	mouse	mouse	NOUN
fnp-3806	2629	34	model	model	NOUN
fnp-3806	2629	35	of	of	ADP
fnp-3806	2629	36	alzheimer	alzheimer	PROPN
fnp-3806	2629	37	's	's	PART
fnp-3806	2629	38	disease	disease	NOUN
fnp-3806	2629	39	.	.	PUNCT
fnp-3806	2630	1	eur	eur	PROPN
fnp-3806	2630	2	j	j	PROPN
fnp-3806	2630	3	neurosci	neurosci	PROPN
fnp-3806	2630	4	2010;32:71	2010;32:71	PROPN
fnp-3806	2630	5	-	-	SYM
fnp-3806	2630	6	79	79	NUM
fnp-3806	2630	7	.	.	PUNCT
fnp-3806	2631	1	https://doi.org/10.1111/j.1460-9568.2010.07274.x	https://doi.org/10.1111/j.1460-9568.2010.07274.x	PROPN
fnp-3806	2631	2	rodríguez	rodríguez	VERB
fnp-3806	2631	3	jj	jj	PROPN
fnp-3806	2631	4	,	,	PUNCT
fnp-3806	2631	5	noristani	noristani	X
fnp-3806	2631	6	hn	hn	PROPN
fnp-3806	2631	7	,	,	PUNCT
fnp-3806	2631	8	verkhratsky	verkhratsky	ADJ
fnp-3806	2631	9	a.	a.	NOUN
fnp-3806	2631	10	the	the	DET
fnp-3806	2631	11	serotonergic	serotonergic	ADJ
fnp-3806	2631	12	system	system	NOUN
fnp-3806	2631	13	in	in	ADP
fnp-3806	2631	14	ageing	ageing	NOUN
fnp-3806	2631	15	and	and	CCONJ
fnp-3806	2631	16	alzheimer	alzheimer	NOUN
fnp-3806	2631	17	's	's	PART
fnp-3806	2631	18	disease	disease	NOUN
fnp-3806	2631	19	.	.	PUNCT
fnp-3806	2632	1	prog	prog	PROPN
fnp-3806	2632	2	neurobiol	neurobiol	PROPN
fnp-3806	2632	3	2012;99:15	2012;99:15	PROPN
fnp-3806	2632	4	-	-	SYM
fnp-3806	2632	5	41	41	NUM
fnp-3806	2632	6	.	.	PUNCT
fnp-3806	2633	1	https://doi.org/10.1016/j.pneurobio.2012.06.010	https://doi.org/10.1016/j.pneurobio.2012.06.010	NOUN
fnp-3806	2633	2	švob	švob	PROPN
fnp-3806	2633	3	štrac	štrac	PROPN
fnp-3806	2634	1	d	d	PROPN
fnp-3806	2634	2	,	,	PUNCT
fnp-3806	2634	3	pivac	pivac	PROPN
fnp-3806	2634	4	n	n	CCONJ
fnp-3806	2634	5	,	,	PUNCT
fnp-3806	2634	6	mück	mück	ADJ
fnp-3806	2634	7	-	-	PUNCT
fnp-3806	2634	8	šeler	šeler	NOUN
fnp-3806	2634	9	d.	d.	NOUN
fnp-3806	2635	1	the	the	DET
fnp-3806	2635	2	serotoninergic	serotoninergic	ADJ
fnp-3806	2635	3	system	system	NOUN
fnp-3806	2635	4	and	and	CCONJ
fnp-3806	2635	5	cognitive	cognitive	ADJ
fnp-3806	2635	6	function	function	NOUN
fnp-3806	2635	7	.	.	PUNCT
fnp-3806	2636	1	transl	transl	PROPN
fnp-3806	2636	2	neurosci	neurosci	PROPN
fnp-3806	2636	3	2016;7:35	2016;7:35	PROPN
fnp-3806	2636	4	-	-	SYM
fnp-3806	2636	5	49	49	NUM
fnp-3806	2636	6	.	.	PUNCT
fnp-3806	2637	1	https://doi.org/10.1515/tnsci-2016-0007	https://doi.org/10.1515/tnsci-2016-0007	PROPN
fnp-3806	2637	2	meltzer	meltzer	PROPN
fnp-3806	2637	3	cc	cc	PROPN
fnp-3806	2637	4	,	,	PUNCT
fnp-3806	2637	5	smith	smith	PROPN
fnp-3806	2637	6	g	g	PROPN
fnp-3806	2637	7	,	,	PUNCT
fnp-3806	2637	8	dekosky	dekosky	PROPN
fnp-3806	2637	9	st	st	PROPN
fnp-3806	2637	10	,	,	PUNCT
fnp-3806	2637	11	et	et	PROPN
fnp-3806	2637	12	al	al	PROPN
fnp-3806	2637	13	.	.	PROPN
fnp-3806	2637	14	serotonin	serotonin	VERB
fnp-3806	2637	15	in	in	ADP
fnp-3806	2637	16	aging	age	VERB
fnp-3806	2637	17	,	,	PUNCT
fnp-3806	2637	18	late	late	ADJ
fnp-3806	2637	19	-	-	PUNCT
fnp-3806	2637	20	life	life	NOUN
fnp-3806	2637	21	depression	depression	NOUN
fnp-3806	2637	22	,	,	PUNCT
fnp-3806	2637	23	and	and	CCONJ
fnp-3806	2637	24	alzheimer	alzheimer	PROPN
fnp-3806	2637	25	’s	’s	PART
fnp-3806	2637	26	disease	disease	NOUN
fnp-3806	2637	27	:	:	PUNCT
fnp-3806	2637	28	the	the	DET
fnp-3806	2637	29	emerging	emerge	VERB
fnp-3806	2637	30	role	role	NOUN
fnp-3806	2637	31	of	of	ADP
fnp-3806	2637	32	functional	functional	ADJ
fnp-3806	2637	33	imaging	imaging	NOUN
fnp-3806	2637	34	.	.	PUNCT
fnp-3806	2638	1	neuropsychopharmacology	neuropsychopharmacology	PROPN
fnp-3806	2638	2	1998;18:407	1998;18:407	PROPN
fnp-3806	2638	3	-	-	PUNCT
fnp-3806	2638	4	430	430	NUM
fnp-3806	2638	5	.	.	PUNCT
fnp-3806	2639	1	https://doi.org/10.1016/s0893-133x(97)00194-2	https://doi.org/10.1016/s0893-133x(97)00194-2	PROPN
fnp-3806	2639	2	michelsen	michelsen	PROPN
fnp-3806	2639	3	ka	ka	PROPN
fnp-3806	2639	4	,	,	PUNCT
fnp-3806	2639	5	prickaerts	prickaerts	PROPN
fnp-3806	2639	6	j	j	PROPN
fnp-3806	2639	7	,	,	PUNCT
fnp-3806	2639	8	steinbusch	steinbusch	VERB
fnp-3806	2639	9	hw	hw	PROPN
fnp-3806	2639	10	.	.	PUNCT
fnp-3806	2640	1	the	the	DET
fnp-3806	2640	2	dorsal	dorsal	NOUN
fnp-3806	2640	3	raphe	raphe	NOUN
fnp-3806	2640	4	nucleus	nucleus	NOUN
fnp-3806	2640	5	and	and	CCONJ
fnp-3806	2640	6	serotonin	serotonin	VERB
fnp-3806	2640	7	:	:	PUNCT
fnp-3806	2640	8	implications	implication	NOUN
fnp-3806	2640	9	for	for	ADP
fnp-3806	2640	10	neuroplasticity	neuroplasticity	NOUN
fnp-3806	2640	11	linked	link	VERB
fnp-3806	2640	12	to	to	ADP
fnp-3806	2640	13	major	major	ADJ
fnp-3806	2640	14	depression	depression	NOUN
fnp-3806	2640	15	in	in	ADP
fnp-3806	2640	16	alzheimer	alzheimer	PROPN
fnp-3806	2640	17	’s	’s	PART
fnp-3806	2640	18	disease	disease	NOUN
fnp-3806	2640	19	.	.	PUNCT
fnp-3806	2641	1	prog	prog	NOUN
fnp-3806	2641	2	brain	brain	NOUN
fnp-3806	2641	3	res	re	NOUN
fnp-3806	2641	4	2008;172:233	2008;172:233	NUM
fnp-3806	2641	5	-	-	SYM
fnp-3806	2641	6	264	264	NUM
fnp-3806	2641	7	.	.	PUNCT
fnp-3806	2642	1	https://doi.org/10.1016/s0079-6123(08)00912-6	https://doi.org/10.1016/s0079-6123(08)00912-6	PROPN
fnp-3806	2642	2	yun	yun	PROPN
fnp-3806	2642	3	hm	hm	PROPN
fnp-3806	2642	4	,	,	PUNCT
fnp-3806	2642	5	park	park	PROPN
fnp-3806	2642	6	kr	kr	PROPN
fnp-3806	2642	7	,	,	PUNCT
fnp-3806	2642	8	kim	kim	PROPN
fnp-3806	2642	9	ec	ec	PROPN
fnp-3806	2642	10	,	,	PUNCT
fnp-3806	2642	11	et	et	PROPN
fnp-3806	2642	12	al	al	PROPN
fnp-3806	2642	13	.	.	PROPN
fnp-3806	2642	14	serotonin	serotonin	VERB
fnp-3806	2642	15	6	6	NUM
fnp-3806	2642	16	receptor	receptor	NOUN
fnp-3806	2642	17	controls	control	VERB
fnp-3806	2642	18	alzheimer	alzheimer	PROPN
fnp-3806	2642	19	's	's	PART
fnp-3806	2642	20	disease	disease	NOUN
fnp-3806	2642	21	and	and	CCONJ
fnp-3806	2642	22	depression	depression	NOUN
fnp-3806	2642	23	.	.	PUNCT
fnp-3806	2643	1	oncotarget	oncotarget	NOUN
fnp-3806	2643	2	2015;6:26716	2015;6:26716	NOUN
fnp-3806	2643	3	-	-	SYM
fnp-3806	2643	4	26728	26728	NUM
fnp-3806	2643	5	.	.	PUNCT
fnp-3806	2644	1	https://doi.org/10.18632/oncotarget.5777	https://doi.org/10.18632/oncotarget.5777	PROPN
fnp-3806	2644	2	burke	burke	PROPN
fnp-3806	2644	3	ad	ad	NOUN
fnp-3806	2644	4	,	,	PUNCT
fnp-3806	2644	5	goldfarb	goldfarb	PROPN
fnp-3806	2644	6	d	d	PROPN
fnp-3806	2644	7	,	,	PUNCT
fnp-3806	2644	8	bollam	bollam	VERB
fnp-3806	2644	9	p	p	X
fnp-3806	2644	10	,	,	PUNCT
fnp-3806	2644	11	et	et	PROPN
fnp-3806	2644	12	al	al	PROPN
fnp-3806	2644	13	.	.	PUNCT
fnp-3806	2644	14	diagnosing	diagnose	VERB
fnp-3806	2644	15	and	and	CCONJ
fnp-3806	2644	16	treating	treat	VERB
fnp-3806	2644	17	depression	depression	NOUN
fnp-3806	2644	18	in	in	ADP
fnp-3806	2644	19	patients	patient	NOUN
fnp-3806	2644	20	with	with	ADP
fnp-3806	2644	21	alzheimer	alzheimer	PROPN
fnp-3806	2644	22	's	's	PART
fnp-3806	2644	23	disease	disease	NOUN
fnp-3806	2644	24	.	.	PUNCT
fnp-3806	2645	1	neurol	neurol	PROPN
fnp-3806	2645	2	ther	ther	PROPN
fnp-3806	2645	3	2019;8:325	2019;8:325	PROPN
fnp-3806	2645	4	-	-	PROPN
fnp-3806	2645	5	350	350	NUM
fnp-3806	2645	6	.	.	PUNCT
fnp-3806	2646	1	https://doi.org/10.1007/s40120-019-00148-5	https://doi.org/10.1007/s40120-019-00148-5	NUM
fnp-3806	2646	2	cachard	cachard	NOUN
fnp-3806	2646	3	-	-	PUNCT
fnp-3806	2646	4	chastel	chastel	NOUN
fnp-3806	2646	5	m	m	NOUN
fnp-3806	2646	6	,	,	PUNCT
fnp-3806	2646	7	lezoualc’h	lezoualc’h	NOUN
fnp-3806	2646	8	f	f	X
fnp-3806	2646	9	,	,	PUNCT
fnp-3806	2646	10	dewachter	dewachter	PROPN
fnp-3806	2646	11	i	i	PRON
fnp-3806	2646	12	,	,	PUNCT
fnp-3806	2646	13	et	et	PROPN
fnp-3806	2646	14	al	al	PROPN
fnp-3806	2646	15	.	.	PROPN
fnp-3806	2646	16	5	5	NUM
fnp-3806	2646	17	-	-	PUNCT
fnp-3806	2646	18	ht4	ht4	NOUN
fnp-3806	2646	19	receptor	receptor	NOUN
fnp-3806	2646	20	agonists	agonist	NOUN
fnp-3806	2646	21	increase	increase	VERB
fnp-3806	2646	22	sappalpha	sappalpha	ADJ
fnp-3806	2646	23	levels	level	NOUN
fnp-3806	2646	24	in	in	ADP
fnp-3806	2646	25	the	the	DET
fnp-3806	2646	26	cortex	cortex	NOUN
fnp-3806	2646	27	and	and	CCONJ
fnp-3806	2646	28	hippocampus	hippocampus	NOUN
fnp-3806	2646	29	of	of	ADP
fnp-3806	2646	30	male	male	ADJ
fnp-3806	2646	31	c57bl/6j	c57bl/6j	NOUN
fnp-3806	2646	32	mice	mouse	NOUN
fnp-3806	2646	33	.	.	PUNCT
fnp-3806	2647	1	br	br	X
fnp-3806	2648	1	j	j	PROPN
fnp-3806	2648	2	pharmacol	pharmacol	PROPN
fnp-3806	2648	3	2007;150:883	2007;150:883	NUM
fnp-3806	2648	4	-	-	SYM
fnp-3806	2648	5	892	892	NUM
fnp-3806	2648	6	.	.	PUNCT
fnp-3806	2649	1	https://doi.org/10.1038/sj.bjp.0707178	https://doi.org/10.1038/sj.bjp.0707178	X
fnp-3806	2649	2	cirrito	cirrito	PROPN
fnp-3806	2649	3	jr	jr	PROPN
fnp-3806	2649	4	,	,	PUNCT
fnp-3806	2649	5	disabato	disabato	PROPN
fnp-3806	2649	6	bm	bm	PROPN
fnp-3806	2649	7	,	,	PUNCT
fnp-3806	2649	8	restivo	restivo	ADJ
fnp-3806	2649	9	jl	jl	PROPN
fnp-3806	2649	10	,	,	PUNCT
fnp-3806	2649	11	et	et	PROPN
fnp-3806	2649	12	al	al	PROPN
fnp-3806	2649	13	.	.	PROPN
fnp-3806	2649	14	serotonin	serotonin	VERB
fnp-3806	2649	15	signaling	signal	VERB
fnp-3806	2649	16	is	be	AUX
fnp-3806	2649	17	associated	associate	VERB
fnp-3806	2649	18	with	with	ADP
fnp-3806	2649	19	lower	low	ADJ
fnp-3806	2649	20	amyloid	amyloid	NOUN
fnp-3806	2649	21	-	-	PUNCT
fnp-3806	2649	22	β	β	NOUN
fnp-3806	2649	23	levels	level	NOUN
fnp-3806	2649	24	and	and	CCONJ
fnp-3806	2649	25	plaques	plaque	NOUN
fnp-3806	2649	26	in	in	ADP
fnp-3806	2649	27	transgenic	transgenic	NOUN
fnp-3806	2649	28	mice	mouse	NOUN
fnp-3806	2649	29	and	and	CCONJ
fnp-3806	2649	30	humans	human	NOUN
fnp-3806	2649	31	.	.	PUNCT
fnp-3806	2650	1	proc	proc	PROPN
fnp-3806	2650	2	natl	natl	PROPN
fnp-3806	2650	3	acad	acad	PROPN
fnp-3806	2650	4	sci	sci	PROPN
fnp-3806	2650	5	usa	usa	PROPN
fnp-3806	2650	6	2011;108:14968	2011;108:14968	NUM
fnp-3806	2650	7	-	-	SYM
fnp-3806	2650	8	14973	14973	NUM
fnp-3806	2650	9	.	.	PUNCT
fnp-3806	2651	1	https://doi.org/10.1073/pnas.1107411108	https://doi.org/10.1073/pnas.1107411108	PROPN
fnp-3806	2651	2	cochet	cochet	PROPN
fnp-3806	2651	3	m	m	PROPN
fnp-3806	2651	4	,	,	PUNCT
fnp-3806	2651	5	donneger	donneger	ADJ
fnp-3806	2651	6	r	r	NOUN
fnp-3806	2651	7	,	,	PUNCT
fnp-3806	2651	8	cassier	cassi	ADJ
fnp-3806	2651	9	e	e	NOUN
fnp-3806	2651	10	,	,	PUNCT
fnp-3806	2651	11	et	et	PROPN
fnp-3806	2651	12	al	al	PROPN
fnp-3806	2651	13	.	.	PROPN
fnp-3806	2651	14	5	5	NUM
fnp-3806	2651	15	-	-	PUNCT
fnp-3806	2651	16	ht4	ht4	NOUN
fnp-3806	2651	17	receptors	receptor	NOUN
fnp-3806	2651	18	constitutively	constitutively	ADV
fnp-3806	2651	19	promote	promote	VERB
fnp-3806	2651	20	the	the	DET
fnp-3806	2651	21	non	non	ADJ
fnp-3806	2651	22	-	-	ADJ
fnp-3806	2651	23	amyloidogenic	amyloidogenic	ADJ
fnp-3806	2651	24	pathway	pathway	NOUN
fnp-3806	2651	25	of	of	ADP
fnp-3806	2651	26	app	app	NOUN
fnp-3806	2651	27	cleavage	cleavage	NOUN
fnp-3806	2651	28	and	and	CCONJ
fnp-3806	2651	29	interact	interact	VERB
fnp-3806	2651	30	with	with	ADP
fnp-3806	2651	31	adam10	adam10	NOUN
fnp-3806	2651	32	.	.	PUNCT
fnp-3806	2652	1	acs	acs	PROPN
fnp-3806	2652	2	chem	chem	NOUN
fnp-3806	2652	3	neurosci	neurosci	PROPN
fnp-3806	2652	4	2013;4	2013;4	NUM
fnp-3806	2652	5	:	:	PUNCT
fnp-3806	2652	6	130	130	NUM
fnp-3806	2652	7	-	-	SYM
fnp-3806	2652	8	140	140	NUM
fnp-3806	2652	9	.	.	PUNCT
fnp-3806	2652	10	https://doi.org/10.1021/cn300095	https://doi.org/10.1021/cn300095	PROPN
fnp-3806	2652	11	t	t	PROPN
fnp-3806	2652	12	giannoni	giannoni	PROPN
fnp-3806	2652	13	p	p	NOUN
fnp-3806	2652	14	,	,	PUNCT
fnp-3806	2652	15	gaven	gaven	VERB
fnp-3806	2652	16	f	f	X
fnp-3806	2652	17	,	,	PUNCT
fnp-3806	2652	18	de	de	X
fnp-3806	2652	19	bundel	bundel	PROPN
fnp-3806	2652	20	d	d	PROPN
fnp-3806	2652	21	,	,	PUNCT
fnp-3806	2652	22	et	et	PROPN
fnp-3806	2652	23	al	al	PROPN
fnp-3806	2652	24	.	.	PROPN
fnp-3806	2653	1	early	early	PROPN
fnp-3806	2653	2	administration	administration	NOUN
fnp-3806	2653	3	of	of	ADP
fnp-3806	2653	4	rs	rs	PROPN
fnp-3806	2653	5	67333	67333	NUM
fnp-3806	2653	6	,	,	PUNCT
fnp-3806	2653	7	a	a	DET
fnp-3806	2653	8	specific	specific	ADJ
fnp-3806	2653	9	5	5	NUM
fnp-3806	2653	10	-	-	PUNCT
fnp-3806	2653	11	ht4	ht4	NOUN
fnp-3806	2653	12	receptor	receptor	NOUN
fnp-3806	2653	13	agonist	agonist	NOUN
fnp-3806	2653	14	,	,	PUNCT
fnp-3806	2653	15	prevents	prevent	VERB
fnp-3806	2653	16	amyloidogenesis	amyloidogenesis	NOUN
fnp-3806	2653	17	and	and	CCONJ
fnp-3806	2653	18	behavioral	behavioral	ADJ
fnp-3806	2653	19	deficits	deficit	NOUN
fnp-3806	2653	20	in	in	ADP
fnp-3806	2653	21	the	the	DET
fnp-3806	2653	22	5xfad	5xfad	NUM
fnp-3806	2653	23	mouse	mouse	NOUN
fnp-3806	2653	24	model	model	NOUN
fnp-3806	2653	25	of	of	ADP
fnp-3806	2653	26	alzheimer	alzheimer	PROPN
fnp-3806	2653	27	’s	’s	PART
fnp-3806	2653	28	disease	disease	NOUN
fnp-3806	2653	29	.	.	PUNCT
fnp-3806	2654	1	front	front	ADJ
fnp-3806	2654	2	aging	age	VERB
fnp-3806	2654	3	neurosci	neurosci	NOUN
fnp-3806	2654	4	2013;5:96	2013;5:96	VERB
fnp-3806	2654	5	.	.	PUNCT
fnp-3806	2655	1	https://doi.org/10.3389/fnagi.2013.00096	https://doi.org/10.3389/fnagi.2013.00096	PROPN
fnp-3806	2655	2	moser	moser	PROPN
fnp-3806	2655	3	pc	pc	PROPN
fnp-3806	2655	4	,	,	PUNCT
fnp-3806	2655	5	bergis	bergis	PROPN
fnp-3806	2655	6	oe	oe	PROPN
fnp-3806	2655	7	,	,	PUNCT
fnp-3806	2655	8	jegham	jegham	PROPN
fnp-3806	2655	9	s	s	PROPN
fnp-3806	2655	10	,	,	PUNCT
fnp-3806	2655	11	et	et	PROPN
fnp-3806	2655	12	al	al	PROPN
fnp-3806	2655	13	.	.	PUNCT
fnp-3806	2656	1	sl65.0155	sl65.0155	PROPN
fnp-3806	2656	2	,	,	PUNCT
fnp-3806	2656	3	a	a	DET
fnp-3806	2656	4	novel	novel	ADJ
fnp-3806	2656	5	5	5	NUM
fnp-3806	2656	6	-	-	PUNCT
fnp-3806	2656	7	hydroxytryptamine(4	hydroxytryptamine(4	NOUN
fnp-3806	2656	8	)	)	PUNCT
fnp-3806	2656	9	receptor	receptor	NOUN
fnp-3806	2656	10	partial	partial	ADJ
fnp-3806	2656	11	agonist	agonist	NOUN
fnp-3806	2656	12	with	with	ADP
fnp-3806	2656	13	potent	potent	ADJ
fnp-3806	2656	14	cognition	cognition	NOUN
fnp-3806	2656	15	-	-	PUNCT
fnp-3806	2656	16	enhancing	enhance	VERB
fnp-3806	2656	17	properties	property	NOUN
fnp-3806	2656	18	.	.	PUNCT
fnp-3806	2657	1	j	j	PROPN
fnp-3806	2657	2	pharmacol	pharmacol	PROPN
fnp-3806	2657	3	exp	exp	NOUN
fnp-3806	2657	4	ther	ther	PROPN
fnp-3806	2657	5	2002;302:731	2002;302:731	NUM
fnp-3806	2657	6	-	-	SYM
fnp-3806	2657	7	741	741	NUM
fnp-3806	2657	8	.	.	PUNCT
fnp-3806	2658	1	https://doi.org/10.1124/jpet.102.034249	https://doi.org/10.1124/jpet.102.034249	PROPN
fnp-3806	2658	2	lezoualc'h	lezoualc'h	PROPN
fnp-3806	2658	3	f.	f.	PROPN
fnp-3806	2658	4	5	5	NUM
fnp-3806	2658	5	-	-	PUNCT
fnp-3806	2658	6	ht4	ht4	NOUN
fnp-3806	2658	7	receptor	receptor	NOUN
fnp-3806	2658	8	and	and	CCONJ
fnp-3806	2658	9	alzheimer	alzheimer	PROPN
fnp-3806	2658	10	's	's	PART
fnp-3806	2658	11	disease	disease	NOUN
fnp-3806	2658	12	:	:	PUNCT
fnp-3806	2658	13	the	the	DET
fnp-3806	2658	14	amyloid	amyloid	NOUN
fnp-3806	2658	15	connection	connection	NOUN
fnp-3806	2658	16	.	.	PUNCT
fnp-3806	2659	1	exp	exp	PROPN
fnp-3806	2659	2	neurol	neurol	PROPN
fnp-3806	2659	3	2007;205:325	2007;205:325	NUM
fnp-3806	2659	4	-	-	SYM
fnp-3806	2659	5	329	329	NUM
fnp-3806	2659	6	.	.	PUNCT
fnp-3806	2660	1	https://doi.org/10.1016/j.expneurol.2007.02.001	https://doi.org/10.1016/j.expneurol.2007.02.001	VERB
fnp-3806	2660	2	cho	cho	PROPN
fnp-3806	2660	3	s	s	PROPN
fnp-3806	2660	4	,	,	PUNCT
fnp-3806	2660	5	hu	hu	PROPN
fnp-3806	2660	6	y.	y.	PROPN
fnp-3806	2660	7	activation	activation	NOUN
fnp-3806	2660	8	of	of	ADP
fnp-3806	2660	9	5	5	NUM
fnp-3806	2660	10	-	-	PUNCT
fnp-3806	2660	11	ht4	ht4	NOUN
fnp-3806	2660	12	receptors	receptor	NOUN
fnp-3806	2660	13	inhibits	inhibit	VERB
fnp-3806	2660	14	secretion	secretion	NOUN
fnp-3806	2660	15	of	of	ADP
fnp-3806	2660	16	beta	beta	NOUN
fnp-3806	2660	17	-	-	PUNCT
fnp-3806	2660	18	amyloid	amyloid	NOUN
fnp-3806	2660	19	peptides	peptide	NOUN
fnp-3806	2660	20	and	and	CCONJ
fnp-3806	2660	21	increases	increase	VERB
fnp-3806	2660	22	neuronal	neuronal	ADJ
fnp-3806	2660	23	survival	survival	NOUN
fnp-3806	2660	24	.	.	PUNCT
fnp-3806	2661	1	exp	exp	NOUN
fnp-3806	2661	2	neurol	neurol	PROPN
fnp-3806	2661	3	2007;203:274	2007;203:274	NUM
fnp-3806	2661	4	-	-	SYM
fnp-3806	2661	5	278	278	NUM
fnp-3806	2661	6	.	.	PUNCT
fnp-3806	2662	1	https://doi.org/10.1016/j.expneurol.2006.07.021	https://doi.org/10.1016/j.expneurol.2006.07.021	NUM
fnp-3806	2662	2	geldenhuys	geldenhuy	NOUN
fnp-3806	2662	3	wj	wj	NUM
fnp-3806	2662	4	,	,	PUNCT
fnp-3806	2662	5	van	van	PROPN
fnp-3806	2662	6	der	der	PROPN
fnp-3806	2662	7	schyf	schyf	PROPN
fnp-3806	2662	8	cj	cj	PROPN
fnp-3806	2662	9	.	.	PUNCT
fnp-3806	2663	1	role	role	NOUN
fnp-3806	2663	2	of	of	ADP
fnp-3806	2663	3	serotonin	serotonin	NOUN
fnp-3806	2663	4	in	in	ADP
fnp-3806	2663	5	alzheimer	alzheimer	PROPN
fnp-3806	2663	6	’s	’s	PART
fnp-3806	2663	7	disease	disease	NOUN
fnp-3806	2663	8	:	:	PUNCT
fnp-3806	2663	9	a	a	DET
fnp-3806	2663	10	new	new	ADJ
fnp-3806	2663	11	therapeutic	therapeutic	ADJ
fnp-3806	2663	12	target	target	NOUN
fnp-3806	2663	13	?	?	PUNCT
fnp-3806	2664	1	cns	cns	NOUN
fnp-3806	2664	2	drugs	drug	NOUN
fnp-3806	2664	3	2011;25:765	2011;25:765	NUM
fnp-3806	2664	4	-	-	SYM
fnp-3806	2664	5	781	781	NUM
fnp-3806	2664	6	.	.	PUNCT
fnp-3806	2665	1	https://doi.org/10.2165/11590190-000000000-00000	https://doi.org/10.2165/11590190-000000000-00000	PROPN
fnp-3806	2665	2	werner	werner	PROPN
fnp-3806	2665	3	fm	fm	PROPN
fnp-3806	2665	4	,	,	PUNCT
fnp-3806	2665	5	covenas	covenas	PROPN
fnp-3806	2665	6	r.	r.	PROPN
fnp-3806	2665	7	serotonergic	serotonergic	NOUN
fnp-3806	2665	8	drugs	drug	NOUN
fnp-3806	2665	9	:	:	PUNCT
fnp-3806	2665	10	agonists	agonist	NOUN
fnp-3806	2665	11	/	/	SYM
fnp-3806	2665	12	antagonists	antagonist	NOUN
fnp-3806	2665	13	at	at	ADP
fnp-3806	2665	14	specific	specific	ADJ
fnp-3806	2665	15	serotonergic	serotonergic	ADJ
fnp-3806	2665	16	subreceptors	subreceptor	NOUN
fnp-3806	2665	17	for	for	ADP
fnp-3806	2665	18	the	the	DET
fnp-3806	2665	19	treatment	treatment	NOUN
fnp-3806	2665	20	of	of	ADP
fnp-3806	2665	21	cognitive	cognitive	ADJ
fnp-3806	2665	22	,	,	PUNCT
fnp-3806	2665	23	depressant	depressant	ADJ
fnp-3806	2665	24	and	and	CCONJ
fnp-3806	2665	25	psychotic	psychotic	ADJ
fnp-3806	2665	26	symptoms	symptom	NOUN
fnp-3806	2665	27	in	in	ADP
fnp-3806	2665	28	alzheimer	alzheimer	PROPN
fnp-3806	2665	29	's	's	PART
fnp-3806	2665	30	disease	disease	NOUN
fnp-3806	2665	31	.	.	PUNCT
fnp-3806	2666	1	curr	curr	PROPN
fnp-3806	2666	2	pharm	pharm	PROPN
fnp-3806	2666	3	des	des	PROPN
fnp-3806	2666	4	2016;22:2064	2016;22:2064	PROPN
fnp-3806	2666	5	-	-	SYM
fnp-3806	2666	6	2071	2071	NUM
fnp-3806	2666	7	.	.	PUNCT
fnp-3806	2667	1	https://doi.org/10.2174/1381612822666160127113524	https://doi.org/10.2174/1381612822666160127113524	DET
fnp-3806	2667	2	magierski	magierski	PROPN
fnp-3806	2667	3	r	r	NOUN
fnp-3806	2667	4	,	,	PUNCT
fnp-3806	2667	5	sobow	sobow	VERB
fnp-3806	2667	6	t.	t.	NOUN
fnp-3806	2667	7	serotonergic	serotonergic	ADJ
fnp-3806	2667	8	drugs	drug	NOUN
fnp-3806	2667	9	for	for	ADP
fnp-3806	2667	10	the	the	DET
fnp-3806	2667	11	treatment	treatment	NOUN
fnp-3806	2667	12	of	of	ADP
fnp-3806	2667	13	neuropsychiatric	neuropsychiatric	ADJ
fnp-3806	2667	14	symptoms	symptom	NOUN
fnp-3806	2667	15	in	in	ADP
fnp-3806	2667	16	dementia	dementia	NOUN
fnp-3806	2667	17	.	.	PUNCT
fnp-3806	2668	1	expert	expert	NOUN
fnp-3806	2668	2	rev	rev	VERB
fnp-3806	2668	3	neurother	neurother	ADJ
fnp-3806	2668	4	2016;16:375	2016;16:375	PROPN
fnp-3806	2668	5	-	-	SYM
fnp-3806	2668	6	387	387	NUM
fnp-3806	2668	7	.	.	PUNCT
fnp-3806	2669	1	https://doi.org/10.1586/14737175.2016.1155453	https://doi.org/10.1586/14737175.2016.1155453	X
fnp-3806	2669	2	ferrero	ferrero	PROPN
fnp-3806	2669	3	h	h	NOUN
fnp-3806	2669	4	,	,	PUNCT
fnp-3806	2669	5	solas	solas	PROPN
fnp-3806	2669	6	m	m	PROPN
fnp-3806	2669	7	,	,	PUNCT
fnp-3806	2669	8	francis	francis	PROPN
fnp-3806	2669	9	pt	pt	PROPN
fnp-3806	2669	10	,	,	PUNCT
fnp-3806	2669	11	et	et	PROPN
fnp-3806	2669	12	al	al	PROPN
fnp-3806	2669	13	.	.	PROPN
fnp-3806	2669	14	serotonin	serotonin	VERB
fnp-3806	2669	15	5	5	NUM
fnp-3806	2669	16	-	-	PUNCT
fnp-3806	2669	17	ht(6	ht(6	NOUN
fnp-3806	2669	18	)	)	PUNCT
fnp-3806	2669	19	receptor	receptor	NOUN
fnp-3806	2669	20	antagonists	antagonist	NOUN
fnp-3806	2669	21	in	in	ADP
fnp-3806	2669	22	alzheimer	alzheimer	PROPN
fnp-3806	2669	23	's	's	PART
fnp-3806	2669	24	disease	disease	NOUN
fnp-3806	2669	25	:	:	PUNCT
fnp-3806	2669	26	therapeutic	therapeutic	ADJ
fnp-3806	2669	27	rationale	rationale	NOUN
fnp-3806	2669	28	and	and	CCONJ
fnp-3806	2669	29	current	current	ADJ
fnp-3806	2669	30	development	development	NOUN
fnp-3806	2669	31	status	status	NOUN
fnp-3806	2669	32	.	.	PUNCT
fnp-3806	2670	1	cns	cns	NOUN
fnp-3806	2670	2	drugs	drug	NOUN
fnp-3806	2670	3	2017;31:19	2017;31:19	NUM
fnp-3806	2670	4	-	-	SYM
fnp-3806	2670	5	32	32	NUM
fnp-3806	2670	6	.	.	PUNCT
fnp-3806	2671	1	https://doi.org/10.1007/s40263-016-0399-3	https://doi.org/10.1007/s40263-016-0399-3	PROPN
fnp-3806	2671	2	brendel	brendel	PROPN
fnp-3806	2671	3	m	m	PROPN
fnp-3806	2671	4	,	,	PUNCT
fnp-3806	2671	5	sauerbeck	sauerbeck	PROPN
fnp-3806	2671	6	j	j	PROPN
fnp-3806	2671	7	,	,	PUNCT
fnp-3806	2671	8	greven	greven	PROPN
fnp-3806	2671	9	s	s	PROPN
fnp-3806	2671	10	,	,	PUNCT
fnp-3806	2671	11	et	et	PROPN
fnp-3806	2671	12	al	al	PROPN
fnp-3806	2671	13	.	.	PROPN
fnp-3806	2671	14	serotonin	serotonin	VERB
fnp-3806	2671	15	selective	selective	ADJ
fnp-3806	2671	16	reuptake	reuptake	NOUN
fnp-3806	2671	17	inhibitor	inhibitor	NOUN
fnp-3806	2671	18	treatment	treatment	NOUN
fnp-3806	2671	19	improves	improve	VERB
fnp-3806	2671	20	cognition	cognition	NOUN
fnp-3806	2671	21	and	and	CCONJ
fnp-3806	2671	22	grey	grey	NOUN
fnp-3806	2671	23	matter	matter	NOUN
fnp-3806	2671	24	atrophy	atrophy	NOUN
fnp-3806	2671	25	but	but	CCONJ
fnp-3806	2671	26	not	not	PART
fnp-3806	2671	27	amyloid	amyloid	NOUN
fnp-3806	2671	28	burden	burden	NOUN
fnp-3806	2671	29	during	during	ADP
fnp-3806	2671	30	two	two	NUM
fnp-3806	2671	31	-	-	PUNCT
fnp-3806	2671	32	year	year	NOUN
fnp-3806	2671	33	follow	follow	NOUN
fnp-3806	2671	34	-	-	PUNCT
fnp-3806	2671	35	up	up	NOUN
fnp-3806	2671	36	in	in	ADP
fnp-3806	2671	37	mild	mild	ADJ
fnp-3806	2671	38	cognitive	cognitive	ADJ
fnp-3806	2671	39	impairment	impairment	NOUN
fnp-3806	2671	40	and	and	CCONJ
fnp-3806	2671	41	alzheimer	alzheimer	NOUN
fnp-3806	2671	42	's	's	PART
fnp-3806	2671	43	disease	disease	NOUN
fnp-3806	2671	44	patients	patient	NOUN
fnp-3806	2671	45	with	with	ADP
fnp-3806	2671	46	depressive	depressive	ADJ
fnp-3806	2671	47	symptoms	symptom	NOUN
fnp-3806	2671	48	.	.	PUNCT
fnp-3806	2672	1	j	j	PROPN
fnp-3806	2672	2	alzheimers	alzheimers	PROPN
fnp-3806	2672	3	dis	dis	PROPN
fnp-3806	2672	4	2018;65:793	2018;65:793	NUM
fnp-3806	2672	5	-	-	SYM
fnp-3806	2672	6	806	806	NUM
fnp-3806	2672	7	.	.	PUNCT
fnp-3806	2673	1	https://doi.org/10.3233/jad-170387	https://doi.org/10.3233/jad-170387	PROPN
fnp-3806	2673	2	manzoor	manzoor	PROPN
fnp-3806	2673	3	s	s	PROPN
fnp-3806	2673	4	,	,	PUNCT
fnp-3806	2673	5	hoda	hoda	PROPN
fnp-3806	2673	6	n.	n.	PROPN
fnp-3806	2673	7	a	a	DET
fnp-3806	2673	8	comprehensive	comprehensive	ADJ
fnp-3806	2673	9	review	review	NOUN
fnp-3806	2673	10	of	of	ADP
fnp-3806	2673	11	monoamine	monoamine	ADJ
fnp-3806	2673	12	oxidase	oxidase	NOUN
fnp-3806	2673	13	inhibitors	inhibitor	NOUN
fnp-3806	2673	14	as	as	ADP
fnp-3806	2673	15	anti	anti	ADJ
fnp-3806	2673	16	-	-	ADJ
fnp-3806	2673	17	alzheimer	alzheimer	ADJ
fnp-3806	2673	18	's	's	PART
fnp-3806	2673	19	disease	disease	NOUN
fnp-3806	2673	20	agents	agent	NOUN
fnp-3806	2673	21	:	:	PUNCT
fnp-3806	2673	22	a	a	DET
fnp-3806	2673	23	review	review	NOUN
fnp-3806	2673	24	.	.	PUNCT
fnp-3806	2674	1	eur	eur	PROPN
fnp-3806	2674	2	j	j	PROPN
fnp-3806	2674	3	med	med	PROPN
fnp-3806	2674	4	chem	chem	NOUN
fnp-3806	2674	5	2020;206:112787	2020;206:112787	NUM
fnp-3806	2674	6	.	.	PUNCT
fnp-3806	2675	1	https://doi.org/10.1016/j.ejmech.2020	https://doi.org/10.1016/j.ejmech.2020	PROPN
fnp-3806	2675	2	112787	112787	NUM
fnp-3806	2675	3	.	.	PUNCT
fnp-3806	2676	1	mdawar	mdawar	PROPN
fnp-3806	2676	2	b	b	PROPN
fnp-3806	2676	3	,	,	PUNCT
fnp-3806	2676	4	ghossoub	ghossoub	PROPN
fnp-3806	2676	5	e	e	PROPN
fnp-3806	2676	6	,	,	PUNCT
fnp-3806	2676	7	khoury	khoury	PROPN
fnp-3806	2676	8	r.	r.	PROPN
fnp-3806	2676	9	selective	selective	ADJ
fnp-3806	2676	10	serotonin	serotonin	NOUN
fnp-3806	2676	11	reuptake	reuptake	NOUN
fnp-3806	2676	12	inhibitors	inhibitor	NOUN
fnp-3806	2676	13	and	and	CCONJ
fnp-3806	2676	14	alzheimer	alzheimer	PROPN
fnp-3806	2676	15	’s	’s	PART
fnp-3806	2676	16	disease	disease	NOUN
fnp-3806	2676	17	.	.	PUNCT
fnp-3806	2677	1	regen	regen	PROPN
fnp-3806	2677	2	res	re	VERB
fnp-3806	2677	3	2020;15:41	2020;15:41	NUM
fnp-3806	2677	4	-	-	SYM
fnp-3806	2677	5	46	46	NUM
fnp-3806	2677	6	.	.	PUNCT
fnp-3806	2678	1	https://doi.org/10.4103/1673-5374.264445	https://doi.org/10.4103/1673-5374.264445	NOUN
fnp-3806	2678	2	kucwaj	kucwaj	PROPN
fnp-3806	2678	3	-	-	PUNCT
fnp-3806	2678	4	brysz	brysz	NOUN
fnp-3806	2678	5	k	k	PROPN
fnp-3806	2678	6	,	,	PUNCT
fnp-3806	2678	7	baltrukevich	baltrukevich	NOUN
fnp-3806	2678	8	h	h	NOUN
fnp-3806	2678	9	,	,	PUNCT
fnp-3806	2678	10	czarnota	czarnota	PROPN
fnp-3806	2678	11	k	k	PROPN
fnp-3806	2678	12	,	,	PUNCT
fnp-3806	2678	13	et	et	PROPN
fnp-3806	2678	14	al	al	PROPN
fnp-3806	2678	15	.	.	PUNCT
fnp-3806	2678	16	chemical	chemical	PROPN
fnp-3806	2678	17	update	update	NOUN
fnp-3806	2678	18	on	on	ADP
fnp-3806	2678	19	the	the	DET
fnp-3806	2678	20	potential	potential	NOUN
fnp-3806	2678	21	for	for	ADP
fnp-3806	2678	22	serotonin	serotonin	VERB
fnp-3806	2678	23	5	5	NUM
fnp-3806	2678	24	-	-	PUNCT
fnp-3806	2678	25	ht(6	ht(6	NOUN
fnp-3806	2678	26	)	)	PUNCT
fnp-3806	2678	27	and	and	CCONJ
fnp-3806	2678	28	5	5	NUM
fnp-3806	2678	29	-	-	PUNCT
fnp-3806	2678	30	ht(7	ht(7	NOUN
fnp-3806	2678	31	)	)	PUNCT
fnp-3806	2678	32	receptor	receptor	NOUN
fnp-3806	2678	33	agents	agent	NOUN
fnp-3806	2678	34	in	in	ADP
fnp-3806	2678	35	the	the	DET
fnp-3806	2678	36	treatment	treatment	NOUN
fnp-3806	2678	37	of	of	ADP
fnp-3806	2678	38	alzheimer	alzheimer	PROPN
fnp-3806	2678	39	's	's	PART
fnp-3806	2678	40	disease	disease	NOUN
fnp-3806	2678	41	.	.	PUNCT
fnp-3806	2679	1	bioorg	bioorg	PROPN
fnp-3806	2679	2	med	med	PROPN
fnp-3806	2679	3	chem	chem	NOUN
fnp-3806	2679	4	lett	lett	NOUN
fnp-3806	2679	5	2021;49:128275	2021;49:128275	NUM
fnp-3806	2679	6	.	.	PUNCT
fnp-3806	2680	1	https://doi.org/10.1016/j.bmcl.2021.128275	https://doi.org/10.1016/j.bmcl.2021.128275	PROPN
fnp-3806	2680	2	pacholczyk	pacholczyk	PROPN
fnp-3806	2680	3	t	t	PROPN
fnp-3806	2680	4	,	,	PUNCT
fnp-3806	2680	5	blakely	blakely	PROPN
fnp-3806	2680	6	rd	rd	PROPN
fnp-3806	2680	7	,	,	PUNCT
fnp-3806	2680	8	amara	amara	PROPN
fnp-3806	2680	9	sg	sg	PROPN
fnp-3806	2680	10	.	.	PUNCT
fnp-3806	2681	1	expression	expression	NOUN
fnp-3806	2681	2	cloning	cloning	NOUN
fnp-3806	2681	3	of	of	ADP
fnp-3806	2681	4	a	a	DET
fnp-3806	2681	5	cocaineand	cocaineand	NOUN
fnp-3806	2681	6	antidepressant	antidepressant	ADJ
fnp-3806	2681	7	-	-	PUNCT
fnp-3806	2681	8	sensitive	sensitive	ADJ
fnp-3806	2681	9	human	human	ADJ
fnp-3806	2681	10	noradrenaline	noradrenaline	ADJ
fnp-3806	2681	11	transporter	transporter	NOUN
fnp-3806	2681	12	.	.	PUNCT
fnp-3806	2682	1	nature	nature	NOUN
fnp-3806	2682	2	1991;350:350	1991;350:350	NUM
fnp-3806	2682	3	-	-	SYM
fnp-3806	2682	4	354	354	NUM
fnp-3806	2682	5	.	.	PUNCT
fnp-3806	2683	1	https://doi.org/10.1038/350350a0	https://doi.org/10.1038/350350a0	PROPN
fnp-3806	2683	2	eiden	eiden	VERB
fnp-3806	2683	3	le	le	X
fnp-3806	2683	4	,	,	PUNCT
fnp-3806	2683	5	schäfer	schäfer	NOUN
fnp-3806	2683	6	mk	mk	PROPN
fnp-3806	2683	7	,	,	PUNCT
fnp-3806	2683	8	weihe	weihe	PROPN
fnp-3806	2683	9	e	e	NOUN
fnp-3806	2683	10	,	,	PUNCT
fnp-3806	2683	11	et	et	PROPN
fnp-3806	2683	12	al	al	PROPN
fnp-3806	2683	13	.	.	PUNCT
fnp-3806	2684	1	the	the	DET
fnp-3806	2684	2	vesicular	vesicular	ADJ
fnp-3806	2684	3	amine	amine	ADJ
fnp-3806	2684	4	transporter	transporter	NOUN
fnp-3806	2684	5	family	family	NOUN
fnp-3806	2684	6	(	(	PUNCT
fnp-3806	2684	7	slc18	slc18	NOUN
fnp-3806	2684	8	):	):	PUNCT
fnp-3806	2684	9	amine	amine	NOUN
fnp-3806	2684	10	/	/	SYM
fnp-3806	2684	11	proton	proton	NOUN
fnp-3806	2684	12	antiporters	antiporter	NOUN
fnp-3806	2684	13	required	require	VERB
fnp-3806	2684	14	for	for	ADP
fnp-3806	2684	15	vesicular	vesicular	ADJ
fnp-3806	2684	16	accumulation	accumulation	NOUN
fnp-3806	2684	17	and	and	CCONJ
fnp-3806	2684	18	regulated	regulate	VERB
fnp-3806	2684	19	exocytotic	exocytotic	ADJ
fnp-3806	2684	20	secretion	secretion	NOUN
fnp-3806	2684	21	of	of	ADP
fnp-3806	2684	22	monoamines	monoamine	NOUN
fnp-3806	2684	23	and	and	CCONJ
fnp-3806	2684	24	acetylcholine	acetylcholine	NOUN
fnp-3806	2684	25	.	.	PUNCT
fnp-3806	2685	1	pflügers	pflüger	NOUN
fnp-3806	2685	2	arch	arch	VERB
fnp-3806	2685	3	.	.	PUNCT
fnp-3806	2686	1	2004;447	2004;447	NOUN
fnp-3806	2686	2	:	:	PUNCT
fnp-3806	2686	3	636	636	NUM
fnp-3806	2686	4	-	-	SYM
fnp-3806	2686	5	640	640	NUM
fnp-3806	2686	6	.	.	PUNCT
fnp-3806	2686	7	https://doi.org/10.1007/s00424-003-1100-5	https://doi.org/10.1007/s00424-003-1100-5	PROPN
fnp-3806	2687	1	ruffolo	ruffolo	PROPN
fnp-3806	2687	2	rr	rr	PROPN
fnp-3806	2687	3	,	,	PUNCT
fnp-3806	2687	4	hieble	hieble	ADJ
fnp-3806	2687	5	jp	jp	PROPN
fnp-3806	2687	6	.	.	PUNCT
fnp-3806	2688	1	alpha	alpha	NOUN
fnp-3806	2688	2	-	-	PUNCT
fnp-3806	2688	3	adrenoreceptors	adrenoreceptor	NOUN
fnp-3806	2688	4	.	.	PUNCT
fnp-3806	2689	1	pharmacol	pharmacol	NOUN
fnp-3806	2689	2	ther	ther	ADV
fnp-3806	2689	3	1994;61:1	1994;61:1	NUM
fnp-3806	2689	4	-	-	SYM
fnp-3806	2689	5	64	64	NUM
fnp-3806	2689	6	.	.	PUNCT
fnp-3806	2690	1	https://doi.org/10.1016/0163-7258(94)90058-2	https://doi.org/10.1016/0163-7258(94)90058-2	NOUN
fnp-3806	2690	2	musacchio	musacchio	PROPN
fnp-3806	2690	3	jm	jm	PROPN
fnp-3806	2690	4	.	.	PROPN
fnp-3806	2690	5	enzymes	enzyme	NOUN
fnp-3806	2690	6	involved	involve	VERB
fnp-3806	2690	7	in	in	ADP
fnp-3806	2690	8	the	the	DET
fnp-3806	2690	9	biosynthesis	biosynthesis	NOUN
fnp-3806	2690	10	and	and	CCONJ
fnp-3806	2690	11	degradation	degradation	NOUN
fnp-3806	2690	12	of	of	ADP
fnp-3806	2690	13	catecholamines	catecholamine	NOUN
fnp-3806	2690	14	.	.	PUNCT
fnp-3806	2691	1	in	in	ADP
fnp-3806	2691	2	:	:	PUNCT
fnp-3806	2691	3	biochemistry	biochemistry	NOUN
fnp-3806	2691	4	of	of	ADP
fnp-3806	2691	5	biogenic	biogenic	ADJ
fnp-3806	2691	6	amines	amine	NOUN
fnp-3806	2691	7	.	.	PUNCT
fnp-3806	2692	1	iverson	iverson	PROPN
fnp-3806	2692	2	l	l	PROPN
fnp-3806	2693	1	(	(	PUNCT
fnp-3806	2693	2	ed	ed	NOUN
fnp-3806	2693	3	)	)	PUNCT
fnp-3806	2693	4	.	.	PUNCT
fnp-3806	2694	1	springer	springer	NOUN
fnp-3806	2694	2	2013	2013	NUM
fnp-3806	2694	3	,	,	PUNCT
fnp-3806	2694	4	pp:1	pp:1	PROPN
fnp-3806	2694	5	-	-	PUNCT
fnp-3806	2694	6	35	35	PROPN
fnp-3806	2694	7	.	.	PUNCT
fnp-3806	2695	1	pickel	pickel	PROPN
fnp-3806	2695	2	vm	vm	PROPN
fnp-3806	2695	3	.	.	PROPN
fnp-3806	2695	4	extrasynaptic	extrasynaptic	ADJ
fnp-3806	2695	5	distribution	distribution	NOUN
fnp-3806	2695	6	of	of	ADP
fnp-3806	2695	7	monoamine	monoamine	ADJ
fnp-3806	2695	8	transporters	transporter	NOUN
fnp-3806	2695	9	and	and	CCONJ
fnp-3806	2695	10	receptors	receptor	NOUN
fnp-3806	2695	11	.	.	PUNCT
fnp-3806	2696	1	prog	prog	NOUN
fnp-3806	2696	2	brain	brain	NOUN
fnp-3806	2696	3	res	re	NOUN
fnp-3806	2696	4	2000;125:267	2000;125:267	NUM
fnp-3806	2696	5	-	-	SYM
fnp-3806	2696	6	276	276	NUM
fnp-3806	2696	7	.	.	PUNCT
fnp-3806	2697	1	https://doi.org/10.1016/s0079-6123(00)25016-4	https://doi.org/10.1016/s0079-6123(00)25016-4	PROPN
fnp-3806	2697	2	perez	perez	PROPN
fnp-3806	2697	3	dm	dm	PROPN
fnp-3806	2697	4	.	.	PUNCT
fnp-3806	2697	5	α1	α1	ADJ
fnp-3806	2697	6	-	-	PUNCT
fnp-3806	2697	7	adrenergic	adrenergic	ADJ
fnp-3806	2697	8	receptors	receptor	NOUN
fnp-3806	2697	9	in	in	ADP
fnp-3806	2697	10	neurotransmission	neurotransmission	NOUN
fnp-3806	2697	11	,	,	PUNCT
fnp-3806	2697	12	synaptic	synaptic	ADJ
fnp-3806	2697	13	plasticity	plasticity	NOUN
fnp-3806	2697	14	,	,	PUNCT
fnp-3806	2697	15	and	and	CCONJ
fnp-3806	2697	16	cognition	cognition	NOUN
fnp-3806	2697	17	.	.	PUNCT
fnp-3806	2698	1	front	front	ADJ
fnp-3806	2698	2	pharmacol	pharmacol	PROPN
fnp-3806	2698	3	2020;11:581098	2020;11:581098	NUM
fnp-3806	2698	4	.	.	PUNCT
fnp-3806	2699	1	https://doi.org/10.3389/fphar.2020.581098	https://doi.org/10.3389/fphar.2020.581098	PROPN
fnp-3806	2699	2	moore	moore	PROPN
fnp-3806	2699	3	ry	ry	PROPN
fnp-3806	2699	4	,	,	PUNCT
fnp-3806	2699	5	bloom	bloom	PROPN
fnp-3806	2699	6	fe	fe	PROPN
fnp-3806	2699	7	.	.	PROPN
fnp-3806	2699	8	central	central	ADJ
fnp-3806	2699	9	catecholamine	catecholamine	PROPN
fnp-3806	2699	10	neuron	neuron	PROPN
fnp-3806	2699	11	systems	system	NOUN
fnp-3806	2699	12	:	:	PUNCT
fnp-3806	2699	13	anatomy	anatomy	NOUN
fnp-3806	2699	14	and	and	CCONJ
fnp-3806	2699	15	physiology	physiology	NOUN
fnp-3806	2699	16	of	of	ADP
fnp-3806	2699	17	the	the	DET
fnp-3806	2699	18	norepinephrine	norepinephrine	NOUN
fnp-3806	2699	19	and	and	CCONJ
fnp-3806	2699	20	epinephrine	epinephrine	NOUN
fnp-3806	2699	21	systems	system	NOUN
fnp-3806	2699	22	.	.	PUNCT
fnp-3806	2700	1	annu	annu	PROPN
fnp-3806	2700	2	rev	rev	VERB
fnp-3806	2700	3	neurosci	neurosci	PROPN
fnp-3806	2700	4	1979	1979	NUM
fnp-3806	2700	5	;	;	PUNCT
fnp-3806	2700	6	2	2	NUM
fnp-3806	2700	7	:	:	SYM
fnp-3806	2700	8	113	113	NUM
fnp-3806	2700	9	-	-	SYM
fnp-3806	2700	10	168	168	NUM
fnp-3806	2700	11	.	.	PUNCT
fnp-3806	2701	1	https://doi.org/10.1146/annurev.ne.02.030179.000553	https://doi.org/10.1146/annurev.ne.02.030179.000553	PROPN
fnp-3806	2701	2	szabadi	szabadi	PROPN
fnp-3806	2701	3	e.	e.	PROPN
fnp-3806	2701	4	functional	functional	PROPN
fnp-3806	2701	5	neuroanatomy	neuroanatomy	NOUN
fnp-3806	2701	6	of	of	ADP
fnp-3806	2701	7	the	the	DET
fnp-3806	2701	8	central	central	ADJ
fnp-3806	2701	9	noradrenergic	noradrenergic	ADJ
fnp-3806	2701	10	system	system	NOUN
fnp-3806	2701	11	.	.	PUNCT
fnp-3806	2702	1	j	j	PROPN
fnp-3806	2702	2	psychopharmacol	psychopharmacol	PROPN
fnp-3806	2702	3	2013;27:659	2013;27:659	PROPN
fnp-3806	2702	4	-	-	NUM
fnp-3806	2702	5	693	693	NUM
fnp-3806	2702	6	.	.	PUNCT
fnp-3806	2703	1	https://doi.org/10.1177/0269881113490326	https://doi.org/10.1177/0269881113490326	NUM
fnp-3806	2703	2	poe	poe	PROPN
fnp-3806	2703	3	gr	gr	PROPN
fnp-3806	2703	4	,	,	PUNCT
fnp-3806	2703	5	foote	foote	NOUN
fnp-3806	2703	6	s	s	PROPN
fnp-3806	2703	7	,	,	PUNCT
fnp-3806	2703	8	eschenko	eschenko	ADJ
fnp-3806	2703	9	o	o	NOUN
fnp-3806	2703	10	,	,	PUNCT
fnp-3806	2703	11	et	et	PROPN
fnp-3806	2703	12	al	al	PROPN
fnp-3806	2703	13	.	.	PUNCT
fnp-3806	2704	1	locus	locus	ADJ
fnp-3806	2704	2	coeruleus	coeruleus	NOUN
fnp-3806	2704	3	:	:	PUNCT
fnp-3806	2704	4	a	a	DET
fnp-3806	2704	5	new	new	ADJ
fnp-3806	2704	6	look	look	NOUN
fnp-3806	2704	7	at	at	ADP
fnp-3806	2704	8	the	the	DET
fnp-3806	2704	9	blue	blue	ADJ
fnp-3806	2704	10	spot	spot	NOUN
fnp-3806	2704	11	.	.	PUNCT
fnp-3806	2705	1	nat	nat	PROPN
fnp-3806	2705	2	rev	rev	PROPN
fnp-3806	2705	3	neurosci	neurosci	PROPN
fnp-3806	2705	4	2020;21:644	2020;21:644	NOUN
fnp-3806	2705	5	-	-	SYM
fnp-3806	2705	6	659	659	NUM
fnp-3806	2705	7	.	.	PUNCT
fnp-3806	2706	1	https://doi.org/10.1038/s41583-020-0360-9	https://doi.org/10.1038/s41583-020-0360-9	NUM
fnp-3806	2707	1	starke	starke	PROPN
fnp-3806	2707	2	k.	k.	PROPN
fnp-3806	2707	3	presynaptic	presynaptic	ADJ
fnp-3806	2707	4	autoreceptors	autoreceptor	NOUN
fnp-3806	2707	5	in	in	ADP
fnp-3806	2707	6	the	the	DET
fnp-3806	2707	7	third	third	ADJ
fnp-3806	2707	8	decade	decade	NOUN
fnp-3806	2707	9	:	:	PUNCT
fnp-3806	2707	10	focus	focus	VERB
fnp-3806	2707	11	on	on	ADP
fnp-3806	2707	12	alpha2	alpha2	NOUN
fnp-3806	2707	13	-	-	PUNCT
fnp-3806	2707	14	adrenoceptors	adrenoceptor	NOUN
fnp-3806	2707	15	.	.	PUNCT
fnp-3806	2708	1	j	j	PROPN
fnp-3806	2708	2	neurochem	neurochem	PROPN
fnp-3806	2708	3	2001;78	2001;78	NUM
fnp-3806	2708	4	:	:	PUNCT
fnp-3806	2708	5	685	685	NUM
fnp-3806	2708	6	-	-	SYM
fnp-3806	2708	7	693	693	NUM
fnp-3806	2708	8	.	.	PUNCT
fnp-3806	2709	1	https://doi.org/10.1046/j.1471-4159.2001.00484.x	https://doi.org/10.1046/j.1471-4159.2001.00484.x	PROPN
fnp-3806	2709	2	nicholas	nicholas	PROPN
fnp-3806	2709	3	ap	ap	PROPN
fnp-3806	2709	4	,	,	PUNCT
fnp-3806	2709	5	pieribone	pieribone	NOUN
fnp-3806	2709	6	v	v	NOUN
fnp-3806	2709	7	,	,	PUNCT
fnp-3806	2709	8	hökfelt	hökfelt	ADJ
fnp-3806	2709	9	t.	t.	NOUN
fnp-3806	2709	10	distributions	distribution	NOUN
fnp-3806	2709	11	of	of	ADP
fnp-3806	2709	12	mrnas	mrna	NOUN
fnp-3806	2709	13	for	for	ADP
fnp-3806	2709	14	alpha-2	alpha-2	NUM
fnp-3806	2709	15	adrenergic	adrenergic	ADJ
fnp-3806	2709	16	receptor	receptor	NOUN
fnp-3806	2709	17	subtypes	subtype	NOUN
fnp-3806	2709	18	in	in	ADP
fnp-3806	2709	19	rat	rat	NOUN
fnp-3806	2709	20	brain	brain	NOUN
fnp-3806	2709	21	:	:	PUNCT
fnp-3806	2709	22	an	an	PRON
fnp-3806	2709	23	in	in	ADP
fnp-3806	2709	24	situ	situ	ADJ
fnp-3806	2709	25	hybridization	hybridization	NOUN
fnp-3806	2709	26	study	study	NOUN
fnp-3806	2709	27	.	.	PUNCT
fnp-3806	2710	1	j	j	PROPN
fnp-3806	2710	2	comp	comp	PROPN
fnp-3806	2710	3	neurol	neurol	PROPN
fnp-3806	2710	4	1993;328	1993;328	NUM
fnp-3806	2710	5	:	:	PUNCT
fnp-3806	2710	6	575	575	NUM
fnp-3806	2710	7	-	-	SYM
fnp-3806	2710	8	594	594	NUM
fnp-3806	2710	9	.	.	PUNCT
fnp-3806	2711	1	https://doi.org/10.1002/cne.903280409	https://doi.org/10.1002/cne.903280409	PROPN
fnp-3806	2711	2	day	day	PROPN
fnp-3806	2712	1	he	he	PRON
fnp-3806	2712	2	,	,	PUNCT
fnp-3806	2712	3	campeau	campeau	PROPN
fnp-3806	2712	4	s	s	PROPN
fnp-3806	2712	5	,	,	PUNCT
fnp-3806	2712	6	watson	watson	PROPN
fnp-3806	2712	7	sj	sj	PROPN
fnp-3806	2712	8	jr	jr	PROPN
fnp-3806	2712	9	,	,	PUNCT
fnp-3806	2712	10	et	et	PROPN
fnp-3806	2712	11	al	al	PROPN
fnp-3806	2712	12	.	.	PUNCT
fnp-3806	2713	1	distribution	distribution	NOUN
fnp-3806	2713	2	of	of	ADP
fnp-3806	2713	3	alpha	alpha	NOUN
fnp-3806	2713	4	1a-	1a-	NUM
fnp-3806	2713	5	,	,	PUNCT
fnp-3806	2713	6	alpha	alpha	NOUN
fnp-3806	2713	7	1band	1band	NUM
fnp-3806	2713	8	alpha	alpha	NOUN
fnp-3806	2713	9	1d	1d	NUM
fnp-3806	2713	10	-	-	PUNCT
fnp-3806	2713	11	adrenergic	adrenergic	ADJ
fnp-3806	2713	12	receptor	receptor	NOUN
fnp-3806	2713	13	mrna	mrna	NOUN
fnp-3806	2713	14	in	in	ADP
fnp-3806	2713	15	the	the	DET
fnp-3806	2713	16	rat	rat	NOUN
fnp-3806	2713	17	brain	brain	NOUN
fnp-3806	2713	18	and	and	CCONJ
fnp-3806	2713	19	spinal	spinal	ADJ
fnp-3806	2713	20	cord	cord	NOUN
fnp-3806	2713	21	.	.	PUNCT
fnp-3806	2714	1	j	j	PROPN
fnp-3806	2714	2	chem	chem	PROPN
fnp-3806	2714	3	neuroanat	neuroanat	PROPN
fnp-3806	2714	4	1997;13:115	1997;13:115	PROPN
fnp-3806	2714	5	-	-	SYM
fnp-3806	2714	6	139	139	NUM
fnp-3806	2714	7	.	.	PUNCT
fnp-3806	2715	1	https://doi.org/10.1016/s0891-0618(97)00042-2	https://doi.org/10.1016/s0891-0618(97)00042-2	PROPN
fnp-3806	2715	2	pieribone	pieribone	PROPN
fnp-3806	2715	3	va	va	PROPN
fnp-3806	2715	4	,	,	PUNCT
fnp-3806	2715	5	nicholas	nicholas	PROPN
fnp-3806	2715	6	ap	ap	PROPN
fnp-3806	2715	7	,	,	PUNCT
fnp-3806	2715	8	dagerlind	dagerlind	VERB
fnp-3806	2715	9	a	a	PRON
fnp-3806	2715	10	,	,	PUNCT
fnp-3806	2715	11	et	et	PROPN
fnp-3806	2715	12	al	al	PROPN
fnp-3806	2715	13	.	.	PUNCT
fnp-3806	2716	1	distribution	distribution	NOUN
fnp-3806	2716	2	of	of	ADP
fnp-3806	2716	3	alpha	alpha	NOUN
fnp-3806	2716	4	1	1	NUM
fnp-3806	2716	5	adrenoceptors	adrenoceptor	NOUN
fnp-3806	2716	6	in	in	ADP
fnp-3806	2716	7	rat	rat	NOUN
fnp-3806	2716	8	brain	brain	NOUN
fnp-3806	2716	9	revealed	reveal	VERB
fnp-3806	2716	10	by	by	ADP
fnp-3806	2716	11	in	in	ADP
fnp-3806	2716	12	situ	situ	ADJ
fnp-3806	2716	13	hybridization	hybridization	NOUN
fnp-3806	2716	14	experiments	experiment	NOUN
fnp-3806	2716	15	utilizing	utilize	VERB
fnp-3806	2716	16	subtype	subtype	NOUN
fnp-3806	2716	17	-	-	PUNCT
fnp-3806	2716	18	specific	specific	ADJ
fnp-3806	2716	19	probes	probe	NOUN
fnp-3806	2716	20	.	.	PUNCT
fnp-3806	2717	1	j	j	PROPN
fnp-3806	2717	2	neurosci	neurosci	PROPN
fnp-3806	2717	3	1994;14:4252	1994;14:4252	NUM
fnp-3806	2717	4	-	-	SYM
fnp-3806	2717	5	4268	4268	NUM
fnp-3806	2717	6	.	.	PUNCT
fnp-3806	2718	1	https://doi.org/10.1523/jneurosci.14-07-04252.1994	https://doi.org/10.1523/jneurosci.14-07-04252.1994	INTJ
fnp-3806	2718	2	domyancic	domyancic	NOUN
fnp-3806	2718	3	av	av	PROPN
fnp-3806	2718	4	,	,	PUNCT
fnp-3806	2718	5	morilak	morilak	PROPN
fnp-3806	2718	6	da	da	X
fnp-3806	2718	7	.	.	PUNCT
fnp-3806	2718	8	distribution	distribution	NOUN
fnp-3806	2718	9	of	of	ADP
fnp-3806	2718	10	alpha1a	alpha1a	NOUN
fnp-3806	2718	11	adrenergic	adrenergic	ADJ
fnp-3806	2718	12	receptor	receptor	NOUN
fnp-3806	2718	13	mrna	mrna	NOUN
fnp-3806	2718	14	in	in	ADP
fnp-3806	2718	15	the	the	DET
fnp-3806	2718	16	rat	rat	NOUN
fnp-3806	2718	17	brain	brain	NOUN
fnp-3806	2718	18	visualized	visualize	VERB
fnp-3806	2718	19	by	by	ADP
fnp-3806	2718	20	in	in	ADP
fnp-3806	2718	21	situ	situ	ADJ
fnp-3806	2718	22	hybridization	hybridization	NOUN
fnp-3806	2718	23	.	.	PUNCT
fnp-3806	2719	1	j	j	PROPN
fnp-3806	2719	2	comp	comp	PROPN
fnp-3806	2719	3	neurol	neurol	PROPN
fnp-3806	2719	4	1997;386:358	1997;386:358	NUM
fnp-3806	2719	5	-	-	SYM
fnp-3806	2719	6	378	378	NUM
fnp-3806	2719	7	.	.	PUNCT
fnp-3806	2719	8	https://doi.org/10.1002/(sici)1096-9861(19970929)386:3<358::aid-cne3>3.0.co;2-0	https://doi.org/10.1002/(sici)1096-9861(19970929)386:3<358::aid-cne3>3.0.co;2-0	ADJ
fnp-3806	2719	9	benarroch	benarroch	PROPN
fnp-3806	2719	10	ee	ee	PROPN
fnp-3806	2719	11	.	.	PUNCT
fnp-3806	2720	1	locus	locus	NOUN
fnp-3806	2720	2	coeruleus	coeruleus	NOUN
fnp-3806	2720	3	.	.	PUNCT
fnp-3806	2721	1	cell	cell	NOUN
fnp-3806	2721	2	tissue	tissue	NOUN
fnp-3806	2721	3	res	re	NOUN
fnp-3806	2721	4	2018;373:221	2018;373:221	NOUN
fnp-3806	2721	5	-	-	SYM
fnp-3806	2721	6	232	232	NUM
fnp-3806	2721	7	.	.	PUNCT
fnp-3806	2722	1	https://doi.org/10.1007/s00441-017-2649-1	https://doi.org/10.1007/s00441-017-2649-1	PROPN
fnp-3806	2722	2	paspalas	paspalas	PROPN
fnp-3806	2722	3	cd	cd	PROPN
fnp-3806	2722	4	papadopoulos	papadopoulos	PROPN
fnp-3806	2722	5	gc	gc	PROPN
fnp-3806	2722	6	.	.	PROPN
fnp-3806	2723	1	ultrastructural	ultrastructural	ADJ
fnp-3806	2723	2	relationships	relationship	NOUN
fnp-3806	2723	3	between	between	ADP
fnp-3806	2723	4	noradrenergic	noradrenergic	ADJ
fnp-3806	2723	5	nerve	nerve	NOUN
fnp-3806	2723	6	fibers	fiber	NOUN
fnp-3806	2723	7	and	and	CCONJ
fnp-3806	2723	8	non	non	ADJ
fnp-3806	2723	9	-	-	ADJ
fnp-3806	2723	10	neuronal	neuronal	ADJ
fnp-3806	2723	11	elements	element	NOUN
fnp-3806	2723	12	in	in	ADP
fnp-3806	2723	13	the	the	DET
fnp-3806	2723	14	rat	rat	NOUN
fnp-3806	2723	15	cerebral	cerebral	ADJ
fnp-3806	2723	16	cortex	cortex	NOUN
fnp-3806	2723	17	.	.	PUNCT
fnp-3806	2724	1	glia	glia	PROPN
fnp-3806	2724	2	1996;17:133	1996;17:133	PROPN
fnp-3806	2724	3	-	-	SYM
fnp-3806	2724	4	146	146	NUM
fnp-3806	2724	5	.	.	PUNCT
fnp-3806	2725	1	https://doi.org/10.1002	https://doi.org/10.1002	PROPN
fnp-3806	2725	2	(	(	PUNCT
fnp-3806	2725	3	sici)1098	sici)1098	PROPN
fnp-3806	2725	4	-	-	PUNCT
fnp-3806	2725	5	1136(199606)17:2<133::aid	1136(199606)17:2<133::aid	VERB
fnp-3806	2725	6	-	-	PUNCT
fnp-3806	2725	7	glia5>3.0.co;2	glia5>3.0.co;2	NOUN
fnp-3806	2725	8	-	-	PUNCT
fnp-3806	2725	9	3	3	NUM
fnp-3806	2725	10	.	.	PUNCT
fnp-3806	2725	11	yoshioka	yoshioka	PROPN
fnp-3806	2725	12	y	y	PROPN
fnp-3806	2725	13	,	,	PUNCT
fnp-3806	2725	14	negoro	negoro	PROPN
fnp-3806	2725	15	r	r	PROPN
fnp-3806	2725	16	,	,	PUNCT
fnp-3806	2725	17	kadoi	kadoi	PROPN
fnp-3806	2725	18	h	h	PROPN
fnp-3806	2725	19	,	,	PUNCT
fnp-3806	2725	20	et	et	PROPN
fnp-3806	2725	21	al	al	PROPN
fnp-3806	2725	22	.	.	PROPN
fnp-3806	2725	23	noradrenaline	noradrenaline	PROPN
fnp-3806	2725	24	protects	protect	VERB
fnp-3806	2725	25	neurons	neuron	NOUN
fnp-3806	2725	26	against	against	ADP
fnp-3806	2725	27	h2o2	h2o2	ADV
fnp-3806	2725	28	-	-	ADJ
fnp-3806	2725	29	induced	induced	ADJ
fnp-3806	2725	30	death	death	NOUN
fnp-3806	2725	31	by	by	ADP
fnp-3806	2725	32	increasing	increase	VERB
fnp-3806	2725	33	the	the	DET
fnp-3806	2725	34	supply	supply	NOUN
fnp-3806	2725	35	of	of	ADP
fnp-3806	2725	36	glutathione	glutathione	NOUN
fnp-3806	2725	37	from	from	ADP
fnp-3806	2725	38	astrocytes	astrocyte	NOUN
fnp-3806	2725	39	via	via	ADP
fnp-3806	2725	40	beta3	beta3	NOUN
fnp-3806	2725	41	-	-	PUNCT
fnp-3806	2725	42	adrenoceptor	adrenoceptor	NOUN
fnp-3806	2725	43	stimulation	stimulation	NOUN
fnp-3806	2725	44	.	.	PUNCT
fnp-3806	2726	1	j	j	PROPN
fnp-3806	2726	2	neurosci	neurosci	PROPN
fnp-3806	2726	3	res	re	NOUN
fnp-3806	2726	4	.	.	PUNCT
fnp-3806	2726	5	2021	2021	NUM
fnp-3806	2726	6	feb;99(2):621	feb;99(2):621	NUM
fnp-3806	2726	7	-	-	PUNCT
fnp-3806	2726	8	637	637	NUM
fnp-3806	2726	9	.	.	PUNCT
fnp-3806	2727	1	https://doi.org/10.1002/jnr.24733	https://doi.org/10.1002/jnr.24733	PROPN
fnp-3806	2727	2	giorgi	giorgi	PROPN
fnp-3806	2727	3	fs	fs	PROPN
fnp-3806	2727	4	,	,	PUNCT
fnp-3806	2727	5	galgani	galgani	PROPN
fnp-3806	2727	6	a	a	DET
fnp-3806	2727	7	,	,	PUNCT
fnp-3806	2727	8	puglisi	puglisi	VERB
fnp-3806	2727	9	-	-	PUNCT
fnp-3806	2727	10	allegra	allegra	ADJ
fnp-3806	2727	11	s	s	PROPN
fnp-3806	2727	12	,	,	PUNCT
fnp-3806	2727	13	et	et	PROPN
fnp-3806	2727	14	al	al	PROPN
fnp-3806	2727	15	.	.	PROPN
fnp-3806	2727	16	,	,	PUNCT
fnp-3806	2727	17	locus	locus	NOUN
fnp-3806	2727	18	coeruleus	coeruleus	NOUN
fnp-3806	2727	19	and	and	CCONJ
fnp-3806	2727	20	neurovascular	neurovascular	ADJ
fnp-3806	2727	21	unit	unit	NOUN
fnp-3806	2727	22	:	:	PUNCT
fnp-3806	2727	23	from	from	ADP
fnp-3806	2727	24	its	its	PRON
fnp-3806	2727	25	role	role	NOUN
fnp-3806	2727	26	in	in	ADP
fnp-3806	2727	27	physiology	physiology	NOUN
fnp-3806	2727	28	to	to	ADP
fnp-3806	2727	29	its	its	PRON
fnp-3806	2727	30	potential	potential	ADJ
fnp-3806	2727	31	role	role	NOUN
fnp-3806	2727	32	in	in	ADP
fnp-3806	2727	33	alzheimer	alzheimer	PROPN
fnp-3806	2727	34	’s	’s	PART
fnp-3806	2727	35	disease	disease	NOUN
fnp-3806	2727	36	pathogenesis	pathogenesis	NOUN
fnp-3806	2727	37	.	.	PUNCT
fnp-3806	2728	1	j	j	PROPN
fnp-3806	2728	2	neurosci	neurosci	PROPN
fnp-3806	2728	3	res	re	VERB
fnp-3806	2728	4	2020;98:2406	2020;98:2406	NUM
fnp-3806	2728	5	-	-	SYM
fnp-3806	2728	6	2434	2434	NUM
fnp-3806	2728	7	.	.	PUNCT
fnp-3806	2729	1	https://doi.org/10.1002/jnr.24718	https://doi.org/10.1002/jnr.24718	PROPN
fnp-3806	2729	2	feinstein	feinstein	PROPN
fnp-3806	2729	3	dl	dl	PROPN
fnp-3806	2729	4	,	,	PUNCT
fnp-3806	2729	5	heneka	heneka	PROPN
fnp-3806	2729	6	mt	mt	PROPN
fnp-3806	2729	7	,	,	PUNCT
fnp-3806	2729	8	gavrilyuk	gavrilyuk	PROPN
fnp-3806	2729	9	v	v	PROPN
fnp-3806	2729	10	,	,	PUNCT
fnp-3806	2729	11	et	et	PROPN
fnp-3806	2729	12	al	al	PROPN
fnp-3806	2729	13	.	.	PUNCT
fnp-3806	2729	14	noradrenergic	noradrenergic	ADJ
fnp-3806	2729	15	regulation	regulation	NOUN
fnp-3806	2729	16	of	of	ADP
fnp-3806	2729	17	inflammatory	inflammatory	ADJ
fnp-3806	2729	18	gene	gene	NOUN
fnp-3806	2729	19	expression	expression	NOUN
fnp-3806	2729	20	in	in	ADP
fnp-3806	2729	21	brain	brain	NOUN
fnp-3806	2729	22	.	.	PUNCT
fnp-3806	2730	1	neurochem	neurochem	PROPN
fnp-3806	2730	2	int	int	VERB
fnp-3806	2730	3	2002;41:357	2002;41:357	NOUN
fnp-3806	2730	4	-	-	SYM
fnp-3806	2730	5	365	365	NUM
fnp-3806	2730	6	.	.	PUNCT
fnp-3806	2731	1	https://doi.org/10.1016/s0197-0186(02)00049-9	https://doi.org/10.1016/s0197-0186(02)00049-9	ADP
fnp-3806	2731	2	bekar	bekar	PROPN
fnp-3806	2731	3	lk	lk	PROPN
fnp-3806	2731	4	,	,	PUNCT
fnp-3806	2731	5	wei	wei	PROPN
fnp-3806	2731	6	hs	hs	PROPN
fnp-3806	2731	7	,	,	PUNCT
fnp-3806	2731	8	nedergaard	nedergaard	ADJ
fnp-3806	2731	9	m.	m.	NOUN
fnp-3806	2731	10	the	the	DET
fnp-3806	2731	11	locus	locus	NOUN
fnp-3806	2731	12	coeruleus	coeruleus	NOUN
fnp-3806	2731	13	-	-	PUNCT
fnp-3806	2731	14	norepinephrine	norepinephrine	NOUN
fnp-3806	2731	15	network	network	NOUN
fnp-3806	2731	16	optimizes	optimize	VERB
fnp-3806	2731	17	coupling	coupling	NOUN
fnp-3806	2731	18	of	of	ADP
fnp-3806	2731	19	cerebral	cerebral	ADJ
fnp-3806	2731	20	blood	blood	NOUN
fnp-3806	2731	21	volume	volume	NOUN
fnp-3806	2731	22	with	with	ADP
fnp-3806	2731	23	oxygen	oxygen	NOUN
fnp-3806	2731	24	demand	demand	NOUN
fnp-3806	2731	25	.	.	PUNCT
fnp-3806	2732	1	j	j	PROPN
fnp-3806	2732	2	cereb	cereb	PROPN
fnp-3806	2732	3	blood	blood	NOUN
fnp-3806	2732	4	flow	flow	NOUN
fnp-3806	2732	5	metab	metab	NOUN
fnp-3806	2732	6	2012;32:2135	2012;32:2135	NOUN
fnp-3806	2732	7	-	-	SYM
fnp-3806	2732	8	2145	2145	NUM
fnp-3806	2732	9	.	.	PUNCT
fnp-3806	2733	1	https://doi.org/10.1038/jcbfm.2012.115	https://doi.org/10.1038/jcbfm.2012.115	PROPN
fnp-3806	2733	2	wirth	wirth	VERB
fnp-3806	2733	3	kj	kj	PROPN
fnp-3806	2733	4	.	.	PUNCT
fnp-3806	2733	5	role	role	NOUN
fnp-3806	2733	6	of	of	ADP
fnp-3806	2733	7	noradrenergic	noradrenergic	ADJ
fnp-3806	2733	8	brain	brain	NOUN
fnp-3806	2733	9	nuclei	nucleus	NOUN
fnp-3806	2733	10	in	in	ADP
fnp-3806	2733	11	the	the	DET
fnp-3806	2733	12	regulation	regulation	NOUN
fnp-3806	2733	13	of	of	ADP
fnp-3806	2733	14	carotid	carotid	NOUN
fnp-3806	2733	15	artery	artery	NOUN
fnp-3806	2733	16	blood	blood	NOUN
fnp-3806	2733	17	flow	flow	NOUN
fnp-3806	2733	18	:	:	PUNCT
fnp-3806	2733	19	pharmacological	pharmacological	ADJ
fnp-3806	2733	20	evidence	evidence	NOUN
fnp-3806	2733	21	from	from	ADP
fnp-3806	2733	22	anesthetized	anesthetized	ADJ
fnp-3806	2733	23	pigs	pig	NOUN
fnp-3806	2733	24	with	with	ADP
fnp-3806	2733	25	alpha-2	alpha-2	ADJ
fnp-3806	2733	26	adrenergic	adrenergic	ADJ
fnp-3806	2733	27	receptor	receptor	NOUN
fnp-3806	2733	28	modulator	modulator	NOUN
fnp-3806	2733	29	drugs	drug	NOUN
fnp-3806	2733	30	.	.	PUNCT
fnp-3806	2734	1	j	j	PROPN
fnp-3806	2734	2	alzheimers	alzheimers	PROPN
fnp-3806	2734	3	dis	dis	PROPN
fnp-3806	2734	4	2018;66:407	2018;66:407	PROPN
fnp-3806	2734	5	-	-	SYM
fnp-3806	2734	6	419	419	NUM
fnp-3806	2734	7	.	.	PUNCT
fnp-3806	2735	1	https://doi.org/10.3233/jad-180340	https://doi.org/10.3233/jad-180340	PROPN
fnp-3806	2735	2	descarries	descarries	PROPN
fnp-3806	2735	3	l	l	PROPN
fnp-3806	2735	4	,	,	PUNCT
fnp-3806	2735	5	mechawar	mechawar	NOUN
fnp-3806	2735	6	n.	n.	ADJ
fnp-3806	2735	7	ultrastructural	ultrastructural	ADJ
fnp-3806	2735	8	evidence	evidence	NOUN
fnp-3806	2735	9	for	for	ADP
fnp-3806	2735	10	diffuse	diffuse	ADJ
fnp-3806	2735	11	transmission	transmission	NOUN
fnp-3806	2735	12	by	by	ADP
fnp-3806	2735	13	monoamine	monoamine	NOUN
fnp-3806	2735	14	and	and	CCONJ
fnp-3806	2735	15	acetylcholine	acetylcholine	NOUN
fnp-3806	2735	16	neurons	neuron	NOUN
fnp-3806	2735	17	of	of	ADP
fnp-3806	2735	18	the	the	DET
fnp-3806	2735	19	central	central	ADJ
fnp-3806	2735	20	nervous	nervous	ADJ
fnp-3806	2735	21	system	system	NOUN
fnp-3806	2735	22	.	.	PUNCT
fnp-3806	2736	1	prog	prog	NOUN
fnp-3806	2736	2	brain	brain	NOUN
fnp-3806	2736	3	res	re	NOUN
fnp-3806	2736	4	2000;125:27	2000;125:27	PROPN
fnp-3806	2736	5	-	-	SYM
fnp-3806	2736	6	47	47	NUM
fnp-3806	2736	7	.	.	PUNCT
fnp-3806	2737	1	https://doi.org/10.1016/s0079-6123(00)25005-x	https://doi.org/10.1016/s0079-6123(00)25005-x	PROPN
fnp-3806	2737	2	watabe	watabe	PROPN
fnp-3806	2737	3	am	am	PROPN
fnp-3806	2737	4	,	,	PUNCT
fnp-3806	2737	5	zaki	zaki	PROPN
fnp-3806	2737	6	pa	pa	PROPN
fnp-3806	2737	7	,	,	PUNCT
fnp-3806	2737	8	o'dell	o'dell	PROPN
fnp-3806	2737	9	tj	tj	PROPN
fnp-3806	2737	10	.	.	PROPN
fnp-3806	2737	11	coactivation	coactivation	NOUN
fnp-3806	2737	12	of	of	ADP
fnp-3806	2737	13	β	β	NOUN
fnp-3806	2737	14	-	-	ADJ
fnp-3806	2737	15	adrenergic	adrenergic	ADJ
fnp-3806	2737	16	and	and	CCONJ
fnp-3806	2737	17	cholinergic	cholinergic	ADJ
fnp-3806	2737	18	receptors	receptor	NOUN
fnp-3806	2737	19	enhances	enhance	VERB
fnp-3806	2737	20	the	the	DET
fnp-3806	2737	21	induction	induction	NOUN
fnp-3806	2737	22	of	of	ADP
fnp-3806	2737	23	long	long	ADJ
fnp-3806	2737	24	-	-	PUNCT
fnp-3806	2737	25	term	term	NOUN
fnp-3806	2737	26	potentiation	potentiation	NOUN
fnp-3806	2737	27	and	and	CCONJ
fnp-3806	2737	28	synergistically	synergistically	ADV
fnp-3806	2737	29	activates	activate	VERB
fnp-3806	2737	30	mitogen	mitogen	NOUN
fnp-3806	2737	31	-	-	PUNCT
fnp-3806	2737	32	activated	activate	VERB
fnp-3806	2737	33	protein	protein	NOUN
fnp-3806	2737	34	kinase	kinase	NOUN
fnp-3806	2737	35	in	in	ADP
fnp-3806	2737	36	the	the	DET
fnp-3806	2737	37	hippocampal	hippocampal	PROPN
fnp-3806	2737	38	ca1	ca1	PROPN
fnp-3806	2737	39	region	region	NOUN
fnp-3806	2737	40	.	.	PUNCT
fnp-3806	2738	1	j	j	PROPN
fnp-3806	2738	2	neurosci	neurosci	PROPN
fnp-3806	2738	3	2000;20	2000;20	NUM
fnp-3806	2738	4	:	:	PUNCT
fnp-3806	2738	5	5924	5924	NUM
fnp-3806	2738	6	-	-	SYM
fnp-3806	2738	7	5931	5931	NUM
fnp-3806	2738	8	.	.	PUNCT
fnp-3806	2739	1	https://doi.org/10.1523/jneurosci.20-16-05924.2000	https://doi.org/10.1523/jneurosci.20-16-05924.2000	PROPN
fnp-3806	2739	2	giorgi	giorgi	PROPN
fnp-3806	2739	3	fs	fs	PROPN
fnp-3806	2739	4	,	,	PUNCT
fnp-3806	2739	5	biagioni	biagioni	NOUN
fnp-3806	2739	6	f	f	X
fnp-3806	2739	7	,	,	PUNCT
fnp-3806	2739	8	galgani	galgani	PROPN
fnp-3806	2739	9	a	a	X
fnp-3806	2739	10	,	,	PUNCT
fnp-3806	2739	11	et	et	PROPN
fnp-3806	2739	12	al	al	PROPN
fnp-3806	2739	13	.	.	PUNCT
fnp-3806	2739	14	locus	locus	ADJ
fnp-3806	2739	15	coeruleus	coeruleus	NOUN
fnp-3806	2739	16	modulates	modulate	VERB
fnp-3806	2739	17	neuroinflammation	neuroinflammation	NOUN
fnp-3806	2739	18	in	in	ADP
fnp-3806	2739	19	parkinsonism	parkinsonism	NOUN
fnp-3806	2739	20	and	and	CCONJ
fnp-3806	2739	21	dementia	dementia	NOUN
fnp-3806	2739	22	.	.	PUNCT
fnp-3806	2740	1	int	int	PROPN
fnp-3806	2740	2	j	j	PROPN
fnp-3806	2740	3	mol	mol	ADP
fnp-3806	2740	4	sci	sci	PROPN
fnp-3806	2740	5	2020	2020	NUM
fnp-3806	2740	6	;	;	PUNCT
fnp-3806	2740	7	21	21	NUM
fnp-3806	2740	8	:	:	PUNCT
fnp-3806	2740	9	8630	8630	NUM
fnp-3806	2740	10	.	.	PUNCT
fnp-3806	2741	1	https://doi.org/10.3390/ijms21228630	https://doi.org/10.3390/ijms21228630	PROPN
fnp-3806	2741	2	brown	brown	PROPN
fnp-3806	2741	3	re	re	PROPN
fnp-3806	2741	4	,	,	PUNCT
fnp-3806	2741	5	sergeeva	sergeeva	PROPN
fnp-3806	2741	6	oa	oa	PROPN
fnp-3806	2741	7	,	,	PUNCT
fnp-3806	2741	8	eriksson	eriksson	PROPN
fnp-3806	2741	9	ks	ks	PROPN
fnp-3806	2741	10	,	,	PUNCT
fnp-3806	2741	11	et	et	PROPN
fnp-3806	2741	12	al	al	PROPN
fnp-3806	2741	13	.	.	PUNCT
fnp-3806	2742	1	convergent	convergent	ADJ
fnp-3806	2742	2	excitation	excitation	NOUN
fnp-3806	2742	3	of	of	ADP
fnp-3806	2742	4	dorsal	dorsal	NOUN
fnp-3806	2742	5	raphe	raphe	NOUN
fnp-3806	2742	6	serotonin	serotonin	NOUN
fnp-3806	2742	7	neurons	neuron	NOUN
fnp-3806	2742	8	by	by	ADP
fnp-3806	2742	9	multiple	multiple	ADJ
fnp-3806	2742	10	arousal	arousal	NOUN
fnp-3806	2742	11	systems	system	NOUN
fnp-3806	2742	12	(	(	PUNCT
fnp-3806	2742	13	orexin	orexin	NOUN
fnp-3806	2742	14	/	/	SYM
fnp-3806	2742	15	hypocretin	hypocretin	NOUN
fnp-3806	2742	16	,	,	PUNCT
fnp-3806	2742	17	histamine	histamine	NOUN
fnp-3806	2742	18	and	and	CCONJ
fnp-3806	2742	19	noradrenaline	noradrenaline	NOUN
fnp-3806	2742	20	)	)	PUNCT
fnp-3806	2742	21	.	.	PUNCT
fnp-3806	2743	1	j	j	PROPN
fnp-3806	2743	2	neurosci	neurosci	PROPN
fnp-3806	2743	3	2002;22	2002;22	NOUN
fnp-3806	2743	4	:	:	PUNCT
fnp-3806	2743	5	8850	8850	NUM
fnp-3806	2743	6	-	-	SYM
fnp-3806	2743	7	8859	8859	NUM
fnp-3806	2743	8	.	.	PUNCT
fnp-3806	2744	1	https://doi.org/10.1523/jneurosci.22-20-08850.2002	https://doi.org/10.1523/jneurosci.22-20-08850.2002	NOUN
fnp-3806	2744	2	morilak	morilak	PROPN
fnp-3806	2744	3	da	da	PROPN
fnp-3806	2744	4	,	,	PUNCT
fnp-3806	2744	5	barrera	barrera	NOUN
fnp-3806	2744	6	g	g	NOUN
fnp-3806	2744	7	,	,	PUNCT
fnp-3806	2744	8	echevarria	echevarria	PROPN
fnp-3806	2744	9	dj	dj	PROPN
fnp-3806	2744	10	,	,	PUNCT
fnp-3806	2744	11	et	et	PROPN
fnp-3806	2744	12	al	al	PROPN
fnp-3806	2744	13	.	.	PUNCT
fnp-3806	2744	14	role	role	NOUN
fnp-3806	2744	15	of	of	ADP
fnp-3806	2744	16	brain	brain	NOUN
fnp-3806	2744	17	norepinephrine	norepinephrine	NOUN
fnp-3806	2744	18	in	in	ADP
fnp-3806	2744	19	the	the	DET
fnp-3806	2744	20	behavioral	behavioral	ADJ
fnp-3806	2744	21	response	response	NOUN
fnp-3806	2744	22	to	to	ADP
fnp-3806	2744	23	stress	stress	NOUN
fnp-3806	2744	24	.	.	PUNCT
fnp-3806	2745	1	prog	prog	PROPN
fnp-3806	2745	2	neuropsychopharmacol	neuropsychopharmacol	PROPN
fnp-3806	2745	3	biol	biol	PROPN
fnp-3806	2745	4	psychiatry	psychiatry	NOUN
fnp-3806	2745	5	2005;29:1214	2005;29:1214	PROPN
fnp-3806	2745	6	-	-	SYM
fnp-3806	2745	7	1224	1224	NUM
fnp-3806	2745	8	.	.	PUNCT
fnp-3806	2746	1	https://doi.org/10.1016/j.pnpbp.2005.08.007	https://doi.org/10.1016/j.pnpbp.2005.08.007	VERB
fnp-3806	2746	2	zarow	zarow	NOUN
fnp-3806	2746	3	c	c	X
fnp-3806	2746	4	,	,	PUNCT
fnp-3806	2746	5	lyness	lyness	ADJ
fnp-3806	2746	6	sa	sa	PROPN
fnp-3806	2746	7	,	,	PUNCT
fnp-3806	2746	8	mortimer	mortimer	PROPN
fnp-3806	2746	9	ja	ja	PROPN
fnp-3806	2746	10	,	,	PUNCT
fnp-3806	2746	11	et	et	PROPN
fnp-3806	2746	12	al	al	PROPN
fnp-3806	2746	13	.	.	PUNCT
fnp-3806	2746	14	neuronal	neuronal	ADJ
fnp-3806	2746	15	loss	loss	NOUN
fnp-3806	2746	16	is	be	AUX
fnp-3806	2746	17	greater	great	ADJ
fnp-3806	2746	18	in	in	ADP
fnp-3806	2746	19	the	the	DET
fnp-3806	2746	20	locus	locus	ADJ
fnp-3806	2746	21	coeruleus	coeruleus	NOUN
fnp-3806	2746	22	than	than	ADP
fnp-3806	2746	23	nucleus	nucleus	ADJ
fnp-3806	2746	24	basalis	basali	NOUN
fnp-3806	2746	25	and	and	CCONJ
fnp-3806	2746	26	substantia	substantia	NOUN
fnp-3806	2746	27	nigra	nigra	PROPN
fnp-3806	2746	28	in	in	ADP
fnp-3806	2746	29	alzheimer	alzheimer	PROPN
fnp-3806	2746	30	and	and	CCONJ
fnp-3806	2746	31	parkinson	parkinson	NOUN
fnp-3806	2746	32	diseases	disease	NOUN
fnp-3806	2746	33	.	.	PUNCT
fnp-3806	2747	1	arch	arch	ADJ
fnp-3806	2747	2	neurol	neurol	NOUN
fnp-3806	2747	3	2003	2003	NUM
fnp-3806	2747	4	;	;	PUNCT
fnp-3806	2747	5	60:337	60:337	NUM
fnp-3806	2747	6	-	-	SYM
fnp-3806	2747	7	341	341	NUM
fnp-3806	2747	8	.	.	PUNCT
fnp-3806	2748	1	https://doi.org/10.1001/archneur.60.3.337	https://doi.org/10.1001/archneur.60.3.337	PROPN
fnp-3806	2748	2	mravec	mravec	PROPN
fnp-3806	2748	3	b	b	PROPN
fnp-3806	2748	4	,	,	PUNCT
fnp-3806	2748	5	lejavova	lejavova	VERB
fnp-3806	2748	6	k	k	X
fnp-3806	2748	7	,	,	PUNCT
fnp-3806	2748	8	cubinkova	cubinkova	PROPN
fnp-3806	2748	9	v.	v.	ADP
fnp-3806	2748	10	locus	locus	PROPN
fnp-3806	2748	11	(	(	PUNCT
fnp-3806	2748	12	coeruleus	coeruleus	NOUN
fnp-3806	2748	13	)	)	PUNCT
fnp-3806	2748	14	minoris	minoris	NOUN
fnp-3806	2748	15	resistentiae	resistentiae	NOUN
fnp-3806	2748	16	in	in	ADP
fnp-3806	2748	17	pathogenesis	pathogenesis	NOUN
fnp-3806	2748	18	of	of	ADP
fnp-3806	2748	19	alzheimer	alzheimer	PROPN
fnp-3806	2748	20	’s	’s	PART
fnp-3806	2748	21	disease	disease	NOUN
fnp-3806	2748	22	.	.	PUNCT
fnp-3806	2749	1	curr	curr	PROPN
fnp-3806	2749	2	alzheimer	alzheimer	PROPN
fnp-3806	2749	3	res	res	PROPN
fnp-3806	2749	4	2014	2014	NUM
fnp-3806	2749	5	;	;	PUNCT
fnp-3806	2749	6	11	11	NUM
fnp-3806	2749	7	:	:	SYM
fnp-3806	2749	8	992	992	NUM
fnp-3806	2749	9	-	-	SYM
fnp-3806	2749	10	1001	1001	NUM
fnp-3806	2749	11	.	.	PUNCT
fnp-3806	2750	1	https://doi.org/10.2174/1567205011666141107130505	https://doi.org/10.2174/1567205011666141107130505	PROPN
fnp-3806	2750	2	ross	ross	PROPN
fnp-3806	2750	3	ja	ja	PROPN
fnp-3806	2750	4	,	,	PUNCT
fnp-3806	2750	5	mcgonigle	mcgonigle	PROPN
fnp-3806	2750	6	p	p	X
fnp-3806	2750	7	,	,	PUNCT
fnp-3806	2750	8	van	van	PROPN
fnp-3806	2750	9	bockstaele	bockstaele	PROPN
fnp-3806	2750	10	ej	ej	PROPN
fnp-3806	2750	11	.	.	PUNCT
fnp-3806	2750	12	locus	locus	NOUN
fnp-3806	2750	13	coeruleus	coeruleus	NOUN
fnp-3806	2750	14	,	,	PUNCT
fnp-3806	2750	15	norepinephrine	norepinephrine	NOUN
fnp-3806	2750	16	and	and	CCONJ
fnp-3806	2750	17	aβ	aβ	PRON
fnp-3806	2750	18	peptides	peptide	NOUN
fnp-3806	2750	19	in	in	ADP
fnp-3806	2750	20	alzheimer	alzheimer	PROPN
fnp-3806	2750	21	's	's	PART
fnp-3806	2750	22	disease	disease	NOUN
fnp-3806	2750	23	.	.	PUNCT
fnp-3806	2751	1	neurobiol	neurobiol	PROPN
fnp-3806	2751	2	stress	stress	VERB
fnp-3806	2751	3	2015;2:73	2015;2:73	PROPN
fnp-3806	2751	4	-	-	PUNCT
fnp-3806	2751	5	84	84	NUM
fnp-3806	2751	6	.	.	PUNCT
fnp-3806	2752	1	https://doi.org/10.1016/j.ynstr.2015.09.002	https://doi.org/10.1016/j.ynstr.2015.09.002	PROPN
fnp-3806	2752	2	bekdash	bekdash	PROPN
fnp-3806	2752	3	ra	ra	PROPN
fnp-3806	2752	4	.	.	PUNCT
fnp-3806	2753	1	the	the	DET
fnp-3806	2753	2	cholinergic	cholinergic	ADJ
fnp-3806	2753	3	system	system	NOUN
fnp-3806	2753	4	,	,	PUNCT
fnp-3806	2753	5	the	the	DET
fnp-3806	2753	6	adrenergic	adrenergic	ADJ
fnp-3806	2753	7	system	system	NOUN
fnp-3806	2753	8	and	and	CCONJ
fnp-3806	2753	9	the	the	DET
fnp-3806	2753	10	neuropathology	neuropathology	NOUN
fnp-3806	2753	11	of	of	ADP
fnp-3806	2753	12	alzheimer	alzheimer	PROPN
fnp-3806	2753	13	's	's	PART
fnp-3806	2753	14	disease	disease	NOUN
fnp-3806	2753	15	.	.	PUNCT
fnp-3806	2754	1	int	int	PROPN
fnp-3806	2754	2	j	j	PROPN
fnp-3806	2754	3	mol	mol	ADP
fnp-3806	2754	4	sci	sci	PROPN
fnp-3806	2754	5	2021;22:1273	2021;22:1273	PROPN
fnp-3806	2754	6	.	.	PROPN
fnp-3806	2755	1	https://doi.org/10.3390/ijms22031273	https://doi.org/10.3390/ijms22031273	PROPN
fnp-3806	2755	2	lamerand	lamerand	PROPN
fnp-3806	2755	3	s	s	PROPN
fnp-3806	2755	4	,	,	PUNCT
fnp-3806	2755	5	shahidehpour	shahidehpour	ADJ
fnp-3806	2755	6	r	r	NOUN
fnp-3806	2755	7	,	,	PUNCT
fnp-3806	2755	8	ayala	ayala	PROPN
fnp-3806	2755	9	i	i	PROPN
fnp-3806	2755	10	,	,	PUNCT
fnp-3806	2755	11	et	et	PROPN
fnp-3806	2755	12	al	al	PROPN
fnp-3806	2755	13	.	.	PUNCT
fnp-3806	2756	1	calbindin	calbindin	VERB
fnp-3806	2756	2	-	-	PUNCT
fnp-3806	2756	3	d28k	d28k	PROPN
fnp-3806	2756	4	,	,	PUNCT
fnp-3806	2756	5	parvalbumin	parvalbumin	NOUN
fnp-3806	2756	6	,	,	PUNCT
fnp-3806	2756	7	and	and	CCONJ
fnp-3806	2756	8	calretinin	calretinin	VERB
fnp-3806	2756	9	in	in	ADP
fnp-3806	2756	10	young	young	ADJ
fnp-3806	2756	11	and	and	CCONJ
fnp-3806	2756	12	aged	aged	ADJ
fnp-3806	2756	13	human	human	ADJ
fnp-3806	2756	14	locus	locus	NOUN
fnp-3806	2756	15	coeruleus	coeruleus	NOUN
fnp-3806	2756	16	.	.	PUNCT
fnp-3806	2757	1	neurobiol	neurobiol	PROPN
fnp-3806	2757	2	aging	age	VERB
fnp-3806	2757	3	2020;94:243	2020;94:243	PROPN
fnp-3806	2757	4	-	-	SYM
fnp-3806	2757	5	249	249	NUM
fnp-3806	2757	6	.	.	PUNCT
fnp-3806	2758	1	https://doi.org/10.1016/j.neurobiolaging.2020.06.006	https://doi.org/10.1016/j.neurobiolaging.2020.06.006	PROPN
fnp-3806	2758	2	samuels	samuels	PROPN
fnp-3806	2758	3	er	er	INTJ
fnp-3806	2758	4	,	,	PUNCT
fnp-3806	2758	5	szabadi	szabadi	PROPN
fnp-3806	2758	6	e.	e.	PROPN
fnp-3806	2758	7	functional	functional	PROPN
fnp-3806	2758	8	neuroanatomy	neuroanatomy	NOUN
fnp-3806	2758	9	of	of	ADP
fnp-3806	2758	10	the	the	DET
fnp-3806	2758	11	noradrenergic	noradrenergic	ADJ
fnp-3806	2758	12	locus	locus	NOUN
fnp-3806	2758	13	coeruleus	coeruleus	NOUN
fnp-3806	2758	14	:	:	PUNCT
fnp-3806	2758	15	its	its	PRON
fnp-3806	2758	16	roles	role	NOUN
fnp-3806	2758	17	in	in	ADP
fnp-3806	2758	18	the	the	DET
fnp-3806	2758	19	regulation	regulation	NOUN
fnp-3806	2758	20	of	of	ADP
fnp-3806	2758	21	arousal	arousal	NOUN
fnp-3806	2758	22	and	and	CCONJ
fnp-3806	2758	23	autonomic	autonomic	ADJ
fnp-3806	2758	24	function	function	NOUN
fnp-3806	2758	25	part	part	NOUN
fnp-3806	2758	26	ii	ii	PROPN
fnp-3806	2758	27	:	:	PUNCT
fnp-3806	2758	28	physiological	physiological	ADJ
fnp-3806	2758	29	and	and	CCONJ
fnp-3806	2758	30	pharmacological	pharmacological	ADJ
fnp-3806	2758	31	manipulations	manipulation	NOUN
fnp-3806	2758	32	and	and	CCONJ
fnp-3806	2758	33	pathological	pathological	ADJ
fnp-3806	2758	34	alterations	alteration	NOUN
fnp-3806	2758	35	of	of	ADP
fnp-3806	2758	36	locus	locus	ADJ
fnp-3806	2758	37	coeruleus	coeruleus	NOUN
fnp-3806	2758	38	activity	activity	NOUN
fnp-3806	2758	39	in	in	ADP
fnp-3806	2758	40	humans	human	NOUN
fnp-3806	2758	41	.	.	PUNCT
fnp-3806	2759	1	curr	curr	PROPN
fnp-3806	2759	2	neuropharmacol	neuropharmacol	PROPN
fnp-3806	2759	3	2008;6:254	2008;6:254	NOUN
fnp-3806	2759	4	-	-	SYM
fnp-3806	2759	5	285	285	NUM
fnp-3806	2759	6	.	.	PUNCT
fnp-3806	2759	7	https://doi.org/10.2174/157015908785777193	https://doi.org/10.2174/157015908785777193	ADP
fnp-3806	2760	1	trillo	trillo	PROPN
fnp-3806	2760	2	l	l	PROPN
fnp-3806	2760	3	,	,	PUNCT
fnp-3806	2760	4	das	das	PROPN
fnp-3806	2760	5	d	d	PROPN
fnp-3806	2760	6	,	,	PUNCT
fnp-3806	2760	7	hsieh	hsieh	PROPN
fnp-3806	2760	8	w	w	PROPN
fnp-3806	2760	9	,	,	PUNCT
fnp-3806	2760	10	et	et	PROPN
fnp-3806	2760	11	al	al	PROPN
fnp-3806	2760	12	.	.	PROPN
fnp-3806	2760	13	ascending	ascend	VERB
fnp-3806	2760	14	monoaminergic	monoaminergic	ADJ
fnp-3806	2760	15	systems	system	NOUN
fnp-3806	2760	16	alterations	alteration	NOUN
fnp-3806	2760	17	in	in	ADP
fnp-3806	2760	18	alzheimer	alzheimer	PROPN
fnp-3806	2760	19	's	's	PART
fnp-3806	2760	20	disease	disease	NOUN
fnp-3806	2760	21	:	:	PUNCT
fnp-3806	2760	22	translating	translate	VERB
fnp-3806	2760	23	basic	basic	ADJ
fnp-3806	2760	24	science	science	NOUN
fnp-3806	2760	25	into	into	ADP
fnp-3806	2760	26	clinical	clinical	ADJ
fnp-3806	2760	27	care	care	NOUN
fnp-3806	2760	28	.	.	PUNCT
fnp-3806	2761	1	neurosci	neurosci	PROPN
fnp-3806	2761	2	biobehav	biobehav	PROPN
fnp-3806	2761	3	rev	rev	VERB
fnp-3806	2761	4	2013;37:1363	2013;37:1363	NUM
fnp-3806	2761	5	-	-	SYM
fnp-3806	2761	6	1679	1679	NUM
fnp-3806	2761	7	.	.	PUNCT
fnp-3806	2762	1	https://doi.org/10.1016/j.neubiorev.2013.05.008	https://doi.org/10.1016/j.neubiorev.2013.05.008	PROPN
fnp-3806	2762	2	patthy	patthy	ADJ
fnp-3806	2762	3	á	á	PROPN
fnp-3806	2762	4	,	,	PUNCT
fnp-3806	2762	5	murai	murai	PROPN
fnp-3806	2762	6	j	j	PROPN
fnp-3806	2762	7	,	,	PUNCT
fnp-3806	2762	8	hanics	hanics	PROPN
fnp-3806	2762	9	j	j	PROPN
fnp-3806	2762	10	,	,	PUNCT
fnp-3806	2762	11	et	et	PROPN
fnp-3806	2762	12	al	al	PROPN
fnp-3806	2762	13	.	.	PROPN
fnp-3806	2762	14	neuropathology	neuropathology	NOUN
fnp-3806	2762	15	of	of	ADP
fnp-3806	2762	16	the	the	DET
fnp-3806	2762	17	brainstem	brainstem	NOUN
fnp-3806	2762	18	to	to	PART
fnp-3806	2762	19	mechanistically	mechanistically	ADV
fnp-3806	2762	20	understand	understand	VERB
fnp-3806	2762	21	and	and	CCONJ
fnp-3806	2762	22	to	to	PART
fnp-3806	2762	23	treat	treat	VERB
fnp-3806	2762	24	alzheimer	alzheimer	PROPN
fnp-3806	2762	25	's	's	PART
fnp-3806	2762	26	disease	disease	NOUN
fnp-3806	2762	27	.	.	PUNCT
fnp-3806	2763	1	j	j	PROPN
fnp-3806	2763	2	clin	clin	PROPN
fnp-3806	2763	3	med	med	PROPN
fnp-3806	2763	4	2021;10:1555	2021;10:1555	PROPN
fnp-3806	2763	5	.	.	PROPN
fnp-3806	2763	6	cross	cross	PROPN
fnp-3806	2763	7	aj	aj	PROPN
fnp-3806	2763	8	,	,	PUNCT
fnp-3806	2763	9	crow	crow	PROPN
fnp-3806	2763	10	tj	tj	PROPN
fnp-3806	2763	11	,	,	PUNCT
fnp-3806	2763	12	perry	perry	PROPN
fnp-3806	2763	13	ek	ek	PROPN
fnp-3806	2763	14	,	,	PUNCT
fnp-3806	2763	15	et	et	PROPN
fnp-3806	2763	16	al	al	PROPN
fnp-3806	2763	17	.	.	PROPN
fnp-3806	2764	1	reduced	reduce	VERB
fnp-3806	2764	2	dopamine	dopamine	NOUN
fnp-3806	2764	3	beta	beta	NOUN
fnp-3806	2764	4	-	-	PUNCT
fnp-3806	2764	5	hydroxylase	hydroxylase	NOUN
fnp-3806	2764	6	activity	activity	NOUN
fnp-3806	2764	7	in	in	ADP
fnp-3806	2764	8	alzheimer	alzheimer	PROPN
fnp-3806	2764	9	's	's	PART
fnp-3806	2764	10	disease	disease	NOUN
fnp-3806	2764	11	.	.	PUNCT
fnp-3806	2765	1	br	br	PROPN
fnp-3806	2765	2	med	med	PROPN
fnp-3806	2765	3	j	j	PROPN
fnp-3806	2765	4	1981;282:93	1981;282:93	NUM
fnp-3806	2765	5	-	-	SYM
fnp-3806	2765	6	94	94	NUM
fnp-3806	2765	7	.	.	PUNCT
fnp-3806	2766	1	https://doi.org/10.1136/bmj.282.6258.93	https://doi.org/10.1136/bmj.282.6258.93	PROPN
fnp-3806	2766	2	perry	perry	PROPN
fnp-3806	2766	3	ek	ek	PROPN
fnp-3806	2766	4	,	,	PUNCT
fnp-3806	2766	5	tomlinson	tomlinson	PROPN
fnp-3806	2766	6	be	be	PROPN
fnp-3806	2766	7	,	,	PUNCT
fnp-3806	2766	8	blessed	bless	VERB
fnp-3806	2766	9	g	g	PROPN
fnp-3806	2766	10	,	,	PUNCT
fnp-3806	2766	11	et	et	PROPN
fnp-3806	2766	12	al	al	PROPN
fnp-3806	2766	13	.	.	PROPN
fnp-3806	2766	14	neuropathological	neuropathological	ADJ
fnp-3806	2766	15	and	and	CCONJ
fnp-3806	2766	16	biochemical	biochemical	ADJ
fnp-3806	2766	17	observations	observation	NOUN
fnp-3806	2766	18	on	on	ADP
fnp-3806	2766	19	the	the	DET
fnp-3806	2766	20	noradrenergic	noradrenergic	ADJ
fnp-3806	2766	21	system	system	NOUN
fnp-3806	2766	22	in	in	ADP
fnp-3806	2766	23	alzheimer	alzheimer	PROPN
fnp-3806	2766	24	's	's	PART
fnp-3806	2766	25	disease	disease	NOUN
fnp-3806	2766	26	.	.	PUNCT
fnp-3806	2767	1	j	j	PROPN
fnp-3806	2767	2	neurol	neurol	PROPN
fnp-3806	2767	3	sci	sci	PROPN
fnp-3806	2767	4	1981;51:279	1981;51:279	PROPN
fnp-3806	2767	5	-	-	PUNCT
fnp-3806	2767	6	287	287	NUM
fnp-3806	2767	7	.	.	PUNCT
fnp-3806	2768	1	https://doi.org/10.1016/0022-510x(81)90106-4	https://doi.org/10.1016/0022-510x(81)90106-4	PROPN
fnp-3806	2768	2	mustapić	mustapić	PROPN
fnp-3806	2768	3	m	m	PROPN
fnp-3806	2768	4	,	,	PUNCT
fnp-3806	2768	5	presečki	presečki	VERB
fnp-3806	2768	6	p	p	NOUN
fnp-3806	2768	7	,	,	PUNCT
fnp-3806	2768	8	pivac	pivac	NOUN
fnp-3806	2768	9	n	n	CCONJ
fnp-3806	2768	10	,	,	PUNCT
fnp-3806	2768	11	et	et	PROPN
fnp-3806	2768	12	al	al	PROPN
fnp-3806	2768	13	.	.	PUNCT
fnp-3806	2769	1	genotype	genotype	NOUN
fnp-3806	2769	2	-	-	PUNCT
fnp-3806	2769	3	independent	independent	ADJ
fnp-3806	2769	4	decrease	decrease	NOUN
fnp-3806	2769	5	in	in	ADP
fnp-3806	2769	6	plasma	plasma	NOUN
fnp-3806	2769	7	dopamine	dopamine	NOUN
fnp-3806	2769	8	β	β	NOUN
fnp-3806	2769	9	-	-	ADJ
fnp-3806	2769	10	hydroxylase	hydroxylase	ADJ
fnp-3806	2769	11	activity	activity	NOUN
fnp-3806	2769	12	in	in	ADP
fnp-3806	2769	13	alzheimer	alzheimer	PROPN
fnp-3806	2769	14	's	's	PART
fnp-3806	2769	15	disease	disease	NOUN
fnp-3806	2769	16	.	.	PUNCT
fnp-3806	2770	1	prog	prog	PROPN
fnp-3806	2770	2	neuropsychopharmacol	neuropsychopharmacol	PROPN
fnp-3806	2770	3	biol	biol	PROPN
fnp-3806	2770	4	psychiatry	psychiatry	NOUN
fnp-3806	2770	5	2013;44:94	2013;44:94	NUM
fnp-3806	2770	6	-	-	SYM
fnp-3806	2770	7	99	99	NUM
fnp-3806	2770	8	.	.	PUNCT
fnp-3806	2771	1	https://doi.org/10.1016/j.pnpbp.2013.02.002	https://doi.org/10.1016/j.pnpbp.2013.02.002	PROPN
fnp-3806	2771	2	serra	serra	PROPN
fnp-3806	2771	3	l	l	PROPN
fnp-3806	2771	4	,	,	PUNCT
fnp-3806	2771	5	d’amelio	d’amelio	PROPN
fnp-3806	2771	6	m	m	NOUN
fnp-3806	2771	7	,	,	PUNCT
fnp-3806	2771	8	di	di	X
fnp-3806	2771	9	domenico	domenico	PROPN
fnp-3806	2771	10	c	c	PROPN
fnp-3806	2771	11	,	,	PUNCT
fnp-3806	2771	12	et	et	PROPN
fnp-3806	2771	13	al	al	PROPN
fnp-3806	2771	14	.	.	PROPN
fnp-3806	2772	1	in	in	ADP
fnp-3806	2772	2	vivo	vivo	ADJ
fnp-3806	2772	3	mapping	mapping	NOUN
fnp-3806	2772	4	of	of	ADP
fnp-3806	2772	5	brainstem	brainstem	NOUN
fnp-3806	2772	6	nuclei	nucleus	NOUN
fnp-3806	2772	7	functional	functional	ADJ
fnp-3806	2772	8	connectivity	connectivity	NOUN
fnp-3806	2772	9	disruption	disruption	NOUN
fnp-3806	2772	10	in	in	ADP
fnp-3806	2772	11	alzheimer	alzheimer	PROPN
fnp-3806	2772	12	’s	’s	PART
fnp-3806	2772	13	disease	disease	NOUN
fnp-3806	2772	14	.	.	PUNCT
fnp-3806	2773	1	neurobiol	neurobiol	ADJ
fnp-3806	2773	2	aging	age	VERB
fnp-3806	2773	3	2018;72:72	2018;72:72	NUM
fnp-3806	2773	4	-	-	SYM
fnp-3806	2773	5	82	82	NUM
fnp-3806	2773	6	.	.	PUNCT
fnp-3806	2774	1	https://doi.org/10.1016/j.neurobiolaging.2018.08.012	https://doi.org/10.1016/j.neurobiolaging.2018.08.012	PROPN
fnp-3806	2774	2	schöne	schöne	NOUN
fnp-3806	2774	3	c	c	PROPN
fnp-3806	2774	4	,	,	PUNCT
fnp-3806	2774	5	burdakov	burdakov	PROPN
fnp-3806	2774	6	d.	d.	PROPN
fnp-3806	2774	7	orexin	orexin	PROPN
fnp-3806	2774	8	/	/	SYM
fnp-3806	2774	9	hypocretin	hypocretin	NOUN
fnp-3806	2774	10	and	and	CCONJ
fnp-3806	2774	11	organizing	organize	VERB
fnp-3806	2774	12	principles	principle	NOUN
fnp-3806	2774	13	for	for	ADP
fnp-3806	2774	14	a	a	DET
fnp-3806	2774	15	diversity	diversity	NOUN
fnp-3806	2774	16	of	of	ADP
fnp-3806	2774	17	wake	wake	NOUN
fnp-3806	2774	18	-	-	PUNCT
fnp-3806	2774	19	promoting	promote	VERB
fnp-3806	2774	20	neurons	neuron	NOUN
fnp-3806	2774	21	in	in	ADP
fnp-3806	2774	22	the	the	DET
fnp-3806	2774	23	brain	brain	NOUN
fnp-3806	2774	24	.	.	PUNCT
fnp-3806	2775	1	curr	curr	PROPN
fnp-3806	2775	2	top	top	ADJ
fnp-3806	2775	3	behav	behav	PROPN
fnp-3806	2775	4	neurosci	neurosci	NOUN
fnp-3806	2775	5	2017;33:51	2017;33:51	PROPN
fnp-3806	2775	6	-	-	SYM
fnp-3806	2775	7	74	74	NUM
fnp-3806	2775	8	.	.	PUNCT
fnp-3806	2776	1	https://doi.org/10.1007/7854_2016_45	https://doi.org/10.1007/7854_2016_45	PROPN
fnp-3806	2776	2	sakurai	sakurai	PROPN
fnp-3806	2776	3	t	t	PROPN
fnp-3806	2776	4	,	,	PUNCT
fnp-3806	2776	5	saito	saito	PROPN
fnp-3806	2776	6	yc	yc	PROPN
fnp-3806	2776	7	,	,	PUNCT
fnp-3806	2776	8	yanagisawa	yanagisawa	PROPN
fnp-3806	2776	9	m.	m.	NOUN
fnp-3806	2776	10	interaction	interaction	NOUN
fnp-3806	2776	11	between	between	ADP
fnp-3806	2776	12	orexin	orexin	NOUN
fnp-3806	2776	13	neurons	neuron	NOUN
fnp-3806	2776	14	and	and	CCONJ
fnp-3806	2776	15	monoaminergic	monoaminergic	ADJ
fnp-3806	2776	16	systems	system	NOUN
fnp-3806	2776	17	.	.	PUNCT
fnp-3806	2777	1	front	front	ADJ
fnp-3806	2777	2	neurol	neurol	PROPN
fnp-3806	2777	3	neurosci	neurosci	PROPN
fnp-3806	2777	4	2021;45:11	2021;45:11	PROPN
fnp-3806	2777	5	-	-	SYM
fnp-3806	2777	6	21	21	NUM
fnp-3806	2777	7	.	.	PUNCT
fnp-3806	2778	1	https://doi.org/10.1159/000514955	https://doi.org/10.1159/000514955	NOUN
fnp-3806	2778	2	liguori	liguori	ADJ
fnp-3806	2778	3	c.	c.	NOUN
fnp-3806	2778	4	orexin	orexin	PROPN
fnp-3806	2778	5	and	and	CCONJ
fnp-3806	2778	6	alzheimer	alzheimer	PROPN
fnp-3806	2778	7	's	's	PART
fnp-3806	2778	8	disease	disease	NOUN
fnp-3806	2778	9	.	.	PUNCT
fnp-3806	2779	1	curr	curr	PROPN
fnp-3806	2779	2	top	top	ADJ
fnp-3806	2779	3	behav	behav	PROPN
fnp-3806	2779	4	neurosci	neurosci	PROPN
fnp-3806	2779	5	2017;33:305	2017;33:305	PROPN
fnp-3806	2779	6	-	-	SYM
fnp-3806	2779	7	322	322	NUM
fnp-3806	2779	8	.	.	PUNCT
fnp-3806	2780	1	https://doi.org/10.1007/7854_2016_50	https://doi.org/10.1007/7854_2016_50	INTJ
fnp-3806	2780	2	um	um	INTJ
fnp-3806	2780	3	yh	yh	PROPN
fnp-3806	2780	4	,	,	PUNCT
fnp-3806	2780	5	lim	lim	PROPN
fnp-3806	2780	6	hk	hk	PROPN
fnp-3806	2780	7	.	.	PUNCT
fnp-3806	2781	1	orexin	orexin	PROPN
fnp-3806	2781	2	and	and	CCONJ
fnp-3806	2781	3	alzheimer	alzheimer	PROPN
fnp-3806	2781	4	's	's	PART
fnp-3806	2781	5	disease	disease	NOUN
fnp-3806	2781	6	:	:	PUNCT
fnp-3806	2781	7	a	a	DET
fnp-3806	2781	8	new	new	ADJ
fnp-3806	2781	9	perspective	perspective	NOUN
fnp-3806	2781	10	.	.	PUNCT
fnp-3806	2782	1	psychiatry	psychiatry	NOUN
fnp-3806	2782	2	investig	investig	NOUN
fnp-3806	2783	1	2020;17:621	2020;17:621	NUM
fnp-3806	2783	2	-	-	SYM
fnp-3806	2783	3	626	626	NUM
fnp-3806	2783	4	.	.	PUNCT
fnp-3806	2784	1	https://doi.org/10.30773/pi.2020.0136	https://doi.org/10.30773/pi.2020.0136	NOUN
fnp-3806	2784	2	dauvilliers	dauvillier	NOUN
fnp-3806	2784	3	y.	y.	PROPN
fnp-3806	2784	4	hypocretin	hypocretin	NOUN
fnp-3806	2784	5	/	/	SYM
fnp-3806	2784	6	orexin	orexin	NOUN
fnp-3806	2784	7	,	,	PUNCT
fnp-3806	2784	8	sleep	sleep	NOUN
fnp-3806	2784	9	and	and	CCONJ
fnp-3806	2784	10	alzheimer	alzheimer	PROPN
fnp-3806	2784	11	's	's	PART
fnp-3806	2784	12	disease	disease	NOUN
fnp-3806	2784	13	.	.	PUNCT
fnp-3806	2785	1	front	front	ADJ
fnp-3806	2785	2	neurol	neurol	PROPN
fnp-3806	2785	3	neurosci	neurosci	PROPN
fnp-3806	2785	4	2021;45:139	2021;45:139	PROPN
fnp-3806	2785	5	-	-	PUNCT
fnp-3806	2785	6	149	149	NUM
fnp-3806	2785	7	.	.	PUNCT
fnp-3806	2786	1	https://doi.org/10.1159/000514967	https://doi.org/10.1159/000514967	PROPN
fnp-3806	2786	2	fredholm	fredholm	PROPN
fnp-3806	2786	3	bb	bb	PROPN
fnp-3806	2786	4	,	,	PUNCT
fnp-3806	2786	5	ijzerman	ijzerman	PROPN
fnp-3806	2786	6	ap	ap	PROPN
fnp-3806	2786	7	,	,	PUNCT
fnp-3806	2786	8	jacobson	jacobson	PROPN
fnp-3806	2786	9	ka	ka	PROPN
fnp-3806	2786	10	,	,	PUNCT
fnp-3806	2786	11	et	et	PROPN
fnp-3806	2786	12	al	al	PROPN
fnp-3806	2786	13	.	.	PUNCT
fnp-3806	2787	1	international	international	PROPN
fnp-3806	2787	2	union	union	PROPN
fnp-3806	2787	3	of	of	ADP
fnp-3806	2787	4	pharmacology	pharmacology	NOUN
fnp-3806	2787	5	.	.	PUNCT
fnp-3806	2788	1	xxv	xxv	PROPN
fnp-3806	2788	2	.	.	PUNCT
fnp-3806	2789	1	nomenclature	nomenclature	NOUN
fnp-3806	2789	2	and	and	CCONJ
fnp-3806	2789	3	classification	classification	NOUN
fnp-3806	2789	4	of	of	ADP
fnp-3806	2789	5	adenosine	adenosine	ADJ
fnp-3806	2789	6	receptors	receptor	NOUN
fnp-3806	2789	7	.	.	PUNCT
fnp-3806	2790	1	pharmacol	pharmacol	PROPN
fnp-3806	2790	2	rev	rev	VERB
fnp-3806	2790	3	2001;53:527	2001;53:527	NUM
fnp-3806	2790	4	-	-	SYM
fnp-3806	2790	5	552	552	NUM
fnp-3806	2790	6	.	.	PUNCT
fnp-3806	2791	1	pmid	pmid	NOUN
fnp-3806	2791	2	:	:	PUNCT
fnp-3806	2791	3	11734617	11734617	NUM
fnp-3806	2791	4	fredholm	fredholm	NOUN
fnp-3806	2791	5	bb	bb	NOUN
fnp-3806	2791	6	,	,	PUNCT
fnp-3806	2791	7	ijzerman	ijzerman	PROPN
fnp-3806	2791	8	ap	ap	PROPN
fnp-3806	2791	9	,	,	PUNCT
fnp-3806	2791	10	jacobson	jacobson	PROPN
fnp-3806	2791	11	ka	ka	PROPN
fnp-3806	2791	12	,	,	PUNCT
fnp-3806	2791	13	et	et	PROPN
fnp-3806	2791	14	al	al	PROPN
fnp-3806	2791	15	.	.	PUNCT
fnp-3806	2792	1	international	international	PROPN
fnp-3806	2792	2	union	union	PROPN
fnp-3806	2792	3	of	of	ADP
fnp-3806	2792	4	basic	basic	ADJ
fnp-3806	2792	5	and	and	CCONJ
fnp-3806	2792	6	clinical	clinical	ADJ
fnp-3806	2792	7	pharmacology	pharmacology	NOUN
fnp-3806	2792	8	.	.	PUNCT
fnp-3806	2793	1	lxxxi	lxxxi	ADJ
fnp-3806	2793	2	.	.	PUNCT
fnp-3806	2793	3	nomenclature	nomenclature	NOUN
fnp-3806	2793	4	and	and	CCONJ
fnp-3806	2793	5	classification	classification	NOUN
fnp-3806	2793	6	of	of	ADP
fnp-3806	2793	7	adenosine	adenosine	ADJ
fnp-3806	2793	8	receptors	receptor	NOUN
fnp-3806	2793	9	:	:	PUNCT
fnp-3806	2793	10	an	an	DET
fnp-3806	2793	11	update	update	NOUN
fnp-3806	2793	12	.	.	PUNCT
fnp-3806	2794	1	pharmacol	pharmacol	PROPN
fnp-3806	2794	2	rev	rev	VERB
fnp-3806	2794	3	2011;63:1	2011;63:1	NUM
fnp-3806	2794	4	-	-	SYM
fnp-3806	2794	5	34	34	NUM
fnp-3806	2794	6	.	.	PUNCT
fnp-3806	2795	1	https://doi.org/10.1124/pr.110.003285	https://doi.org/10.1124/pr.110.003285	PROPN
fnp-3806	2795	2	cunha	cunha	VERB
fnp-3806	2795	3	ra	ra	PROPN
fnp-3806	2795	4	.	.	PROPN
fnp-3806	2795	5	adenosine	adenosine	VERB
fnp-3806	2795	6	as	as	ADP
fnp-3806	2795	7	a	a	DET
fnp-3806	2795	8	neuromodulator	neuromodulator	NOUN
fnp-3806	2795	9	and	and	CCONJ
fnp-3806	2795	10	as	as	ADP
fnp-3806	2795	11	a	a	DET
fnp-3806	2795	12	homeostatic	homeostatic	ADJ
fnp-3806	2795	13	regulator	regulator	NOUN
fnp-3806	2795	14	in	in	ADP
fnp-3806	2795	15	the	the	DET
fnp-3806	2795	16	nervous	nervous	ADJ
fnp-3806	2795	17	system	system	NOUN
fnp-3806	2795	18	:	:	PUNCT
fnp-3806	2795	19	different	different	ADJ
fnp-3806	2795	20	roles	role	NOUN
fnp-3806	2795	21	,	,	PUNCT
fnp-3806	2795	22	different	different	ADJ
fnp-3806	2795	23	sources	source	NOUN
fnp-3806	2795	24	and	and	CCONJ
fnp-3806	2795	25	different	different	ADJ
fnp-3806	2795	26	receptors	receptor	NOUN
fnp-3806	2795	27	.	.	PUNCT
fnp-3806	2796	1	neurochem	neurochem	PROPN
fnp-3806	2796	2	int	int	VERB
fnp-3806	2796	3	2001;38:107	2001;38:107	PROPN
fnp-3806	2796	4	-	-	SYM
fnp-3806	2796	5	125	125	NUM
fnp-3806	2796	6	.	.	PUNCT
fnp-3806	2797	1	https://doi.org/10.1016/s0197-0186(00)00034-6	https://doi.org/10.1016/s0197-0186(00)00034-6	PROPN
fnp-3806	2797	2	fredholm	fredholm	PROPN
fnp-3806	2797	3	bb	bb	PROPN
fnp-3806	2797	4	,	,	PUNCT
fnp-3806	2797	5	chen	chen	PROPN
fnp-3806	2797	6	jf	jf	PROPN
fnp-3806	2797	7	,	,	PUNCT
fnp-3806	2797	8	cunha	cunha	PROPN
fnp-3806	2797	9	ra	ra	PROPN
fnp-3806	2797	10	,	,	PUNCT
fnp-3806	2797	11	et	et	PROPN
fnp-3806	2797	12	al	al	PROPN
fnp-3806	2797	13	.	.	PROPN
fnp-3806	2797	14	adenosine	adenosine	NOUN
fnp-3806	2797	15	and	and	CCONJ
fnp-3806	2797	16	brain	brain	NOUN
fnp-3806	2797	17	function	function	NOUN
fnp-3806	2797	18	.	.	PUNCT
fnp-3806	2798	1	int	int	PROPN
fnp-3806	2798	2	rev	rev	PROPN
fnp-3806	2798	3	neurobiol	neurobiol	PROPN
fnp-3806	2798	4	2005;63:191	2005;63:191	PROPN
fnp-3806	2798	5	-	-	SYM
fnp-3806	2798	6	270	270	NUM
fnp-3806	2798	7	.	.	PUNCT
fnp-3806	2799	1	https://doi.org/10.1016/s0074-7742(05)63007-3	https://doi.org/10.1016/s0074-7742(05)63007-3	PROPN
fnp-3806	2799	2	sheth	sheth	PROPN
fnp-3806	2799	3	s	s	PROPN
fnp-3806	2799	4	,	,	PUNCT
fnp-3806	2799	5	brito	brito	PROPN
fnp-3806	2799	6	r	r	PROPN
fnp-3806	2799	7	,	,	PUNCT
fnp-3806	2799	8	mukherjea	mukherjea	PROPN
fnp-3806	2799	9	d	d	PROPN
fnp-3806	2799	10	,	,	PUNCT
fnp-3806	2799	11	et	et	PROPN
fnp-3806	2799	12	al	al	PROPN
fnp-3806	2799	13	.	.	PROPN
fnp-3806	2799	14	adenosine	adenosine	NOUN
fnp-3806	2799	15	receptors	receptor	NOUN
fnp-3806	2799	16	:	:	PUNCT
fnp-3806	2799	17	expression	expression	NOUN
fnp-3806	2799	18	,	,	PUNCT
fnp-3806	2799	19	function	function	NOUN
fnp-3806	2799	20	and	and	CCONJ
fnp-3806	2799	21	regulation	regulation	NOUN
fnp-3806	2799	22	.	.	PUNCT
fnp-3806	2800	1	int	int	PROPN
fnp-3806	2800	2	j	j	PROPN
fnp-3806	2800	3	mol	mol	ADP
fnp-3806	2800	4	sci	sci	PROPN
fnp-3806	2800	5	2014	2014	NUM
fnp-3806	2800	6	;	;	PUNCT
fnp-3806	2800	7	15	15	NUM
fnp-3806	2800	8	:	:	SYM
fnp-3806	2800	9	2024	2024	NUM
fnp-3806	2800	10	-	-	SYM
fnp-3806	2800	11	2052	2052	NUM
fnp-3806	2800	12	.	.	PUNCT
fnp-3806	2801	1	https://doi.org/10.3390/ijms15022024	https://doi.org/10.3390/ijms15022024	NOUN
fnp-3806	2801	2	sebastiao	sebastiao	NOUN
fnp-3806	2801	3	am	be	AUX
fnp-3806	2801	4	,	,	PUNCT
fnp-3806	2801	5	ribeiro	ribeiro	PROPN
fnp-3806	2801	6	ja	ja	PROPN
fnp-3806	2801	7	.	.	PUNCT
fnp-3806	2801	8	adenosine	adenosine	PROPN
fnp-3806	2801	9	a2	a2	PROPN
fnp-3806	2801	10	receptor	receptor	NOUN
fnp-3806	2801	11	-	-	PUNCT
fnp-3806	2801	12	mediated	mediate	VERB
fnp-3806	2801	13	excitatory	excitatory	ADJ
fnp-3806	2801	14	actions	action	NOUN
fnp-3806	2801	15	on	on	ADP
fnp-3806	2801	16	the	the	DET
fnp-3806	2801	17	nervous	nervous	ADJ
fnp-3806	2801	18	system	system	NOUN
fnp-3806	2801	19	.	.	PUNCT
fnp-3806	2802	1	prog	prog	PROPN
fnp-3806	2802	2	neurobiol	neurobiol	PROPN
fnp-3806	2802	3	1996;48:167	1996;48:167	NUM
fnp-3806	2802	4	-	-	SYM
fnp-3806	2802	5	189	189	NUM
fnp-3806	2802	6	.	.	PUNCT
fnp-3806	2802	7	https://doi.org/10.1016/0301-0082(95)00035-6	https://doi.org/10.1016/0301-0082(95)00035-6	PROPN
fnp-3806	2802	8	cunha	cunha	PROPN
fnp-3806	2802	9	ra	ra	PROPN
fnp-3806	2802	10	,	,	PUNCT
fnp-3806	2802	11	almeida	almeida	PROPN
fnp-3806	2802	12	t	t	PROPN
fnp-3806	2802	13	,	,	PUNCT
fnp-3806	2802	14	ribeiro	ribeiro	PROPN
fnp-3806	2802	15	ja	ja	PROPN
fnp-3806	2802	16	.	.	PUNCT
fnp-3806	2802	17	modification	modification	NOUN
fnp-3806	2802	18	by	by	ADP
fnp-3806	2802	19	arachidonic	arachidonic	ADJ
fnp-3806	2802	20	acid	acid	NOUN
fnp-3806	2802	21	of	of	ADP
fnp-3806	2802	22	extracellular	extracellular	ADJ
fnp-3806	2802	23	adenosine	adenosine	NOUN
fnp-3806	2802	24	metabolism	metabolism	NOUN
fnp-3806	2802	25	and	and	CCONJ
fnp-3806	2802	26	neuromodulatory	neuromodulatory	ADJ
fnp-3806	2802	27	action	action	NOUN
fnp-3806	2802	28	in	in	ADP
fnp-3806	2802	29	the	the	DET
fnp-3806	2802	30	rat	rat	NOUN
fnp-3806	2802	31	hippocampus	hippocampus	NOUN
fnp-3806	2802	32	.	.	PUNCT
fnp-3806	2803	1	j	j	PROPN
fnp-3806	2803	2	biol	biol	PROPN
fnp-3806	2803	3	chem	chem	NOUN
fnp-3806	2803	4	2000;275:37572	2000;275:37572	NUM
fnp-3806	2803	5	-	-	SYM
fnp-3806	2803	6	37581	37581	NUM
fnp-3806	2803	7	.	.	PUNCT
fnp-3806	2804	1	https://doi.org/10.1074/jbc.m003011200	https://doi.org/10.1074/jbc.m003011200	X
fnp-3806	2804	2	brand	brand	PROPN
fnp-3806	2804	3	a	a	PRON
fnp-3806	2804	4	,	,	PUNCT
fnp-3806	2804	5	vissiennon	vissiennon	PROPN
fnp-3806	2804	6	z	z	NOUN
fnp-3806	2804	7	,	,	PUNCT
fnp-3806	2804	8	eschke	eschke	ADJ
fnp-3806	2804	9	d	d	NOUN
fnp-3806	2804	10	,	,	PUNCT
fnp-3806	2804	11	et	et	PROPN
fnp-3806	2804	12	al	al	PROPN
fnp-3806	2804	13	.	.	PROPN
fnp-3806	2804	14	adenosine	adenosine	PROPN
fnp-3806	2804	15	a(1	a(1	NOUN
fnp-3806	2804	16	)	)	PUNCT
fnp-3806	2804	17	and	and	CCONJ
fnp-3806	2804	18	a(3	a(3	PROPN
fnp-3806	2804	19	)	)	PUNCT
fnp-3806	2804	20	receptors	receptor	NOUN
fnp-3806	2804	21	mediate	mediate	VERB
fnp-3806	2804	22	inhibition	inhibition	NOUN
fnp-3806	2804	23	of	of	ADP
fnp-3806	2804	24	synaptic	synaptic	ADJ
fnp-3806	2804	25	transmission	transmission	NOUN
fnp-3806	2804	26	in	in	ADP
fnp-3806	2804	27	rat	rat	NOUN
fnp-3806	2804	28	cortical	cortical	ADJ
fnp-3806	2804	29	neurons	neuron	NOUN
fnp-3806	2804	30	.	.	PUNCT
fnp-3806	2805	1	neuropharmacology	neuropharmacology	NOUN
fnp-3806	2805	2	2001;40:85–95	2001;40:85–95	NUM
fnp-3806	2805	3	.	.	PUNCT
fnp-3806	2806	1	https://doi.org/10.1016/s0028-3908(00)00117-9	https://doi.org/10.1016/s0028-3908(00)00117-9	VERB
fnp-3806	2806	2	hettinger	hettinger	NOUN
fnp-3806	2806	3	bd	bd	PROPN
fnp-3806	2806	4	,	,	PUNCT
fnp-3806	2806	5	lee	lee	PROPN
fnp-3806	2806	6	a	a	PROPN
fnp-3806	2806	7	,	,	PUNCT
fnp-3806	2806	8	linden	linden	PROPN
fnp-3806	2806	9	j	j	PROPN
fnp-3806	2806	10	,	,	PUNCT
fnp-3806	2806	11	et	et	PROPN
fnp-3806	2806	12	al	al	PROPN
fnp-3806	2806	13	.	.	PUNCT
fnp-3806	2807	1	ultrastructural	ultrastructural	ADJ
fnp-3806	2807	2	localization	localization	NOUN
fnp-3806	2807	3	of	of	ADP
fnp-3806	2807	4	adenosine	adenosine	ADJ
fnp-3806	2807	5	a2a	a2a	NOUN
fnp-3806	2807	6	receptors	receptor	NOUN
fnp-3806	2807	7	suggests	suggest	VERB
fnp-3806	2807	8	multiple	multiple	ADJ
fnp-3806	2807	9	cellular	cellular	ADJ
fnp-3806	2807	10	sites	site	NOUN
fnp-3806	2807	11	for	for	ADP
fnp-3806	2807	12	modulation	modulation	NOUN
fnp-3806	2807	13	of	of	ADP
fnp-3806	2807	14	gabaergic	gabaergic	ADJ
fnp-3806	2807	15	neurons	neuron	NOUN
fnp-3806	2807	16	in	in	ADP
fnp-3806	2807	17	rat	rat	NOUN
fnp-3806	2807	18	striatum	striatum	NOUN
fnp-3806	2807	19	.	.	PUNCT
fnp-3806	2808	1	j	j	PROPN
fnp-3806	2808	2	comp	comp	PROPN
fnp-3806	2808	3	neurol	neurol	PROPN
fnp-3806	2808	4	2001;431:331	2001;431:331	NUM
fnp-3806	2808	5	-	-	SYM
fnp-3806	2808	6	346	346	NUM
fnp-3806	2808	7	.	.	PUNCT
fnp-3806	2809	1	https://doi.org/10.1002/1096-9861(20010312)431:3<331::aid-cne1074>3.0.co;2-w	https://doi.org/10.1002/1096-9861(20010312)431:3<331::aid-cne1074>3.0.co;2-w	PROPN
fnp-3806	2809	2	lopes	lopes	PROPN
fnp-3806	2809	3	lv	lv	PROPN
fnp-3806	2809	4	,	,	PUNCT
fnp-3806	2809	5	cunha	cunha	PROPN
fnp-3806	2809	6	ra	ra	PROPN
fnp-3806	2809	7	,	,	PUNCT
fnp-3806	2809	8	kull	kull	PROPN
fnp-3806	2809	9	b	b	PROPN
fnp-3806	2809	10	,	,	PUNCT
fnp-3806	2809	11	et	et	PROPN
fnp-3806	2809	12	al	al	PROPN
fnp-3806	2809	13	.	.	PROPN
fnp-3806	2809	14	adenosine	adenosine	PROPN
fnp-3806	2809	15	a(2a	a(2a	ADJ
fnp-3806	2809	16	)	)	PUNCT
fnp-3806	2809	17	receptor	receptor	NOUN
fnp-3806	2809	18	facilitation	facilitation	NOUN
fnp-3806	2809	19	of	of	ADP
fnp-3806	2809	20	hippocampal	hippocampal	ADJ
fnp-3806	2809	21	synaptic	synaptic	ADJ
fnp-3806	2809	22	transmission	transmission	NOUN
fnp-3806	2809	23	is	be	AUX
fnp-3806	2809	24	dependent	dependent	ADJ
fnp-3806	2809	25	on	on	ADP
fnp-3806	2809	26	tonic	tonic	NOUN
fnp-3806	2809	27	a(1	a(1	NOUN
fnp-3806	2809	28	)	)	PUNCT
fnp-3806	2809	29	receptor	receptor	NOUN
fnp-3806	2809	30	inhibition	inhibition	NOUN
fnp-3806	2809	31	.	.	PUNCT
fnp-3806	2810	1	neuroscience	neuroscience	NOUN
fnp-3806	2810	2	2002;112:319	2002;112:319	NUM
fnp-3806	2810	3	-	-	SYM
fnp-3806	2810	4	329	329	NUM
fnp-3806	2810	5	.	.	PUNCT
fnp-3806	2811	1	https://doi.org/10.1016/s0306-4522(02)00080-5	https://doi.org/10.1016/s0306-4522(02)00080-5	PROPN
fnp-3806	2811	2	rebola	rebola	PROPN
fnp-3806	2811	3	n	n	PROPN
fnp-3806	2811	4	,	,	PUNCT
fnp-3806	2811	5	oliveira	oliveira	PROPN
fnp-3806	2811	6	cr	cr	PROPN
fnp-3806	2811	7	,	,	PUNCT
fnp-3806	2811	8	cunha	cunha	PROPN
fnp-3806	2811	9	ra	ra	PROPN
fnp-3806	2811	10	.	.	PUNCT
fnp-3806	2811	11	transducing	transducing	NOUN
fnp-3806	2811	12	system	system	NOUN
fnp-3806	2811	13	operated	operate	VERB
fnp-3806	2811	14	by	by	ADP
fnp-3806	2811	15	adenosine	adenosine	NOUN
fnp-3806	2811	16	a(2a	a(2a	NOUN
fnp-3806	2811	17	)	)	PUNCT
fnp-3806	2811	18	receptors	receptor	NOUN
fnp-3806	2811	19	to	to	PART
fnp-3806	2811	20	facilitate	facilitate	VERB
fnp-3806	2811	21	acetylcholine	acetylcholine	NOUN
fnp-3806	2811	22	release	release	NOUN
fnp-3806	2811	23	in	in	ADP
fnp-3806	2811	24	the	the	DET
fnp-3806	2811	25	rat	rat	NOUN
fnp-3806	2811	26	hippocampus	hippocampus	NOUN
fnp-3806	2811	27	.	.	PUNCT
fnp-3806	2812	1	eur	eur	PROPN
fnp-3806	2812	2	j	j	PROPN
fnp-3806	2812	3	pharmacol	pharmacol	PROPN
fnp-3806	2812	4	2002;454:31	2002;454:31	NUM
fnp-3806	2812	5	-	-	SYM
fnp-3806	2812	6	38	38	NUM
fnp-3806	2812	7	.	.	PUNCT
fnp-3806	2813	1	https://doi.org/10.1016/s0014-2999(02)02475-5	https://doi.org/10.1016/s0014-2999(02)02475-5	PROPN
fnp-3806	2813	2	rebola	rebola	PROPN
fnp-3806	2813	3	n	n	CCONJ
fnp-3806	2813	4	,	,	PUNCT
fnp-3806	2813	5	rodrigues	rodrigues	PROPN
fnp-3806	2813	6	rj	rj	PROPN
fnp-3806	2813	7	,	,	PUNCT
fnp-3806	2813	8	oliveira	oliveira	PROPN
fnp-3806	2813	9	cr	cr	PROPN
fnp-3806	2813	10	,	,	PUNCT
fnp-3806	2813	11	et	et	PROPN
fnp-3806	2813	12	al	al	PROPN
fnp-3806	2813	13	.	.	PUNCT
fnp-3806	2814	1	different	different	ADJ
fnp-3806	2814	2	roles	role	NOUN
fnp-3806	2814	3	of	of	ADP
fnp-3806	2814	4	adenosine	adenosine	ADJ
fnp-3806	2814	5	a1	a1	NOUN
fnp-3806	2814	6	,	,	PUNCT
fnp-3806	2814	7	a2a	a2a	PROPN
fnp-3806	2814	8	and	and	CCONJ
fnp-3806	2814	9	a3	a3	NOUN
fnp-3806	2814	10	receptors	receptor	NOUN
fnp-3806	2814	11	in	in	ADP
fnp-3806	2814	12	controlling	control	VERB
fnp-3806	2814	13	kainate	kainate	NOUN
fnp-3806	2814	14	-	-	PUNCT
fnp-3806	2814	15	induced	induce	VERB
fnp-3806	2814	16	toxicity	toxicity	NOUN
fnp-3806	2814	17	in	in	ADP
fnp-3806	2814	18	cortical	cortical	ADJ
fnp-3806	2814	19	cultured	cultured	ADJ
fnp-3806	2814	20	neurons	neuron	NOUN
fnp-3806	2814	21	.	.	PUNCT
fnp-3806	2815	1	neurochem	neurochem	PROPN
fnp-3806	2815	2	int	int	VERB
fnp-3806	2815	3	2005;47:317	2005;47:317	NOUN
fnp-3806	2815	4	-	-	SYM
fnp-3806	2815	5	325	325	NUM
fnp-3806	2815	6	.	.	PUNCT
fnp-3806	2816	1	https://doi.org/10.1016/j.neuint.2005.05.009	https://doi.org/10.1016/j.neuint.2005.05.009	PROPN
fnp-3806	2816	2	kalaria	kalaria	PROPN
fnp-3806	2816	3	rn	rn	PROPN
fnp-3806	2816	4	,	,	PUNCT
fnp-3806	2816	5	sromek	sromek	PROPN
fnp-3806	2816	6	s	s	PART
fnp-3806	2816	7	,	,	PUNCT
fnp-3806	2816	8	wilcox	wilcox	PROPN
fnp-3806	2816	9	bj	bj	PROPN
fnp-3806	2816	10	,	,	PUNCT
fnp-3806	2816	11	et	et	PROPN
fnp-3806	2816	12	al	al	PROPN
fnp-3806	2816	13	.	.	PROPN
fnp-3806	2816	14	hippocampal	hippocampal	ADJ
fnp-3806	2816	15	adenosine	adenosine	NOUN
fnp-3806	2816	16	a1	a1	NOUN
fnp-3806	2816	17	receptors	receptor	NOUN
fnp-3806	2816	18	are	be	AUX
fnp-3806	2816	19	decreased	decrease	VERB
fnp-3806	2816	20	in	in	ADP
fnp-3806	2816	21	alzheimer	alzheimer	PROPN
fnp-3806	2816	22	’s	’s	PART
fnp-3806	2816	23	disease	disease	NOUN
fnp-3806	2816	24	.	.	PUNCT
fnp-3806	2817	1	neurosci	neurosci	PROPN
fnp-3806	2817	2	lett	lett	PROPN
fnp-3806	2817	3	1990;118:257	1990;118:257	PROPN
fnp-3806	2817	4	-	-	SYM
fnp-3806	2817	5	260	260	NUM
fnp-3806	2817	6	.	.	PUNCT
fnp-3806	2818	1	https://doi.org/10.1016/0304-3940(90)90641-l	https://doi.org/10.1016/0304-3940(90)90641-l	PROPN
fnp-3806	2818	2	ulas	ulas	PROPN
fnp-3806	2818	3	j	j	PROPN
fnp-3806	2818	4	,	,	PUNCT
fnp-3806	2818	5	brunner	brunner	PROPN
fnp-3806	2818	6	lc	lc	PROPN
fnp-3806	2818	7	,	,	PUNCT
fnp-3806	2818	8	nguyen	nguyen	PROPN
fnp-3806	2818	9	l	l	PROPN
fnp-3806	2818	10	,	,	PUNCT
fnp-3806	2818	11	et	et	PROPN
fnp-3806	2818	12	al	al	PROPN
fnp-3806	2818	13	.	.	PROPN
fnp-3806	2818	14	reduced	reduce	VERB
fnp-3806	2818	15	density	density	NOUN
fnp-3806	2818	16	of	of	ADP
fnp-3806	2818	17	adenosine	adenosine	ADJ
fnp-3806	2818	18	a1	a1	NOUN
fnp-3806	2818	19	receptors	receptor	NOUN
fnp-3806	2818	20	and	and	CCONJ
fnp-3806	2818	21	preserved	preserve	VERB
fnp-3806	2818	22	coupling	coupling	NOUN
fnp-3806	2818	23	of	of	ADP
fnp-3806	2818	24	adenosine	adenosine	ADJ
fnp-3806	2818	25	a1	a1	NOUN
fnp-3806	2818	26	receptors	receptor	NOUN
fnp-3806	2818	27	to	to	ADP
fnp-3806	2818	28	g	g	NOUN
fnp-3806	2818	29	proteins	protein	NOUN
fnp-3806	2818	30	in	in	ADP
fnp-3806	2818	31	alzheimer	alzheimer	PROPN
fnp-3806	2818	32	hippocampus	hippocampus	PROPN
fnp-3806	2818	33	:	:	PUNCT
fnp-3806	2818	34	a	a	DET
fnp-3806	2818	35	quantitative	quantitative	ADJ
fnp-3806	2818	36	autoradiographic	autoradiographic	ADJ
fnp-3806	2818	37	study	study	NOUN
fnp-3806	2818	38	.	.	PUNCT
fnp-3806	2819	1	neuroscience	neuroscience	NOUN
fnp-3806	2819	2	1993;52:843	1993;52:843	PROPN
fnp-3806	2819	3	-	-	SYM
fnp-3806	2819	4	854	854	NUM
fnp-3806	2819	5	.	.	PUNCT
fnp-3806	2820	1	https://doi.org/10.1016/0306-4522(93)90533-l	https://doi.org/10.1016/0306-4522(93)90533-l	PROPN
fnp-3806	2820	2	streit	streit	PROPN
fnp-3806	2820	3	wj	wj	PROPN
fnp-3806	2820	4	,	,	PUNCT
fnp-3806	2820	5	braak	braak	PROPN
fnp-3806	2820	6	h	h	PROPN
fnp-3806	2820	7	,	,	PUNCT
fnp-3806	2820	8	xue	xue	PROPN
fnp-3806	2820	9	qs	qs	PROPN
fnp-3806	2820	10	,	,	PUNCT
fnp-3806	2820	11	et	et	PROPN
fnp-3806	2820	12	al	al	PROPN
fnp-3806	2820	13	.	.	PROPN
fnp-3806	2820	14	dystrophic	dystrophic	ADJ
fnp-3806	2820	15	(	(	PUNCT
fnp-3806	2820	16	senescent	senescent	NOUN
fnp-3806	2820	17	)	)	PUNCT
fnp-3806	2820	18	rather	rather	ADV
fnp-3806	2820	19	than	than	ADP
fnp-3806	2820	20	activated	activate	VERB
fnp-3806	2820	21	microglial	microglial	ADJ
fnp-3806	2820	22	cells	cell	NOUN
fnp-3806	2820	23	are	be	AUX
fnp-3806	2820	24	associated	associate	VERB
fnp-3806	2820	25	with	with	ADP
fnp-3806	2820	26	tau	tau	PROPN
fnp-3806	2820	27	pathology	pathology	NOUN
fnp-3806	2820	28	and	and	CCONJ
fnp-3806	2820	29	likely	likely	ADV
fnp-3806	2820	30	precede	precede	VERB
fnp-3806	2820	31	neurodegeneration	neurodegeneration	NOUN
fnp-3806	2820	32	in	in	ADP
fnp-3806	2820	33	alzheimer	alzheimer	PROPN
fnp-3806	2820	34	's	's	PART
fnp-3806	2820	35	disease	disease	NOUN
fnp-3806	2820	36	.	.	PUNCT
fnp-3806	2821	1	acta	acta	PROPN
fnp-3806	2821	2	neuropathol	neuropathol	PROPN
fnp-3806	2821	3	.	.	PUNCT
fnp-3806	2822	1	2009;118:475	2009;118:475	NUM
fnp-3806	2822	2	-	-	SYM
fnp-3806	2822	3	485	485	NUM
fnp-3806	2822	4	.	.	PUNCT
fnp-3806	2823	1	https://doi.org/10.1007/s00401-009-0556-6	https://doi.org/10.1007/s00401-009-0556-6	PROPN
fnp-3806	2823	2	deckert	deckert	PROPN
fnp-3806	2823	3	j	j	PROPN
fnp-3806	2823	4	,	,	PUNCT
fnp-3806	2823	5	abel	abel	PROPN
fnp-3806	2823	6	f	f	PROPN
fnp-3806	2823	7	,	,	PUNCT
fnp-3806	2823	8	kunig	kunig	PROPN
fnp-3806	2823	9	g	g	PROPN
fnp-3806	2823	10	,	,	PUNCT
fnp-3806	2823	11	et	et	PROPN
fnp-3806	2823	12	al	al	PROPN
fnp-3806	2823	13	.	.	PUNCT
fnp-3806	2823	14	loss	loss	NOUN
fnp-3806	2823	15	of	of	ADP
fnp-3806	2823	16	human	human	ADJ
fnp-3806	2823	17	hippocampal	hippocampal	ADJ
fnp-3806	2823	18	adenosine	adenosine	NOUN
fnp-3806	2823	19	a1	a1	NOUN
fnp-3806	2823	20	receptors	receptor	NOUN
fnp-3806	2823	21	in	in	ADP
fnp-3806	2823	22	dementia	dementia	NOUN
fnp-3806	2823	23	:	:	PUNCT
fnp-3806	2823	24	evidence	evidence	NOUN
fnp-3806	2823	25	for	for	ADP
fnp-3806	2823	26	lack	lack	NOUN
fnp-3806	2823	27	of	of	ADP
fnp-3806	2823	28	specificity	specificity	NOUN
fnp-3806	2823	29	.	.	PUNCT
fnp-3806	2824	1	neurosci	neurosci	PROPN
fnp-3806	2824	2	lett	lett	PROPN
fnp-3806	2824	3	1998;244:1	1998;244:1	PROPN
fnp-3806	2824	4	-	-	SYM
fnp-3806	2824	5	4	4	NUM
fnp-3806	2824	6	.	.	PUNCT
fnp-3806	2824	7	https://doi.org/10.1016/s0304-3940(98)00108-6	https://doi.org/10.1016/s0304-3940(98)00108-6	PROPN
fnp-3806	2824	8	angulo	angulo	PROPN
fnp-3806	2824	9	e	e	PROPN
fnp-3806	2824	10	,	,	PUNCT
fnp-3806	2824	11	casado	casado	VERB
fnp-3806	2824	12	v	v	NOUN
fnp-3806	2824	13	,	,	PUNCT
fnp-3806	2824	14	mallol	mallol	PROPN
fnp-3806	2824	15	j	j	PROPN
fnp-3806	2824	16	,	,	PUNCT
fnp-3806	2824	17	et	et	PROPN
fnp-3806	2825	1	al	al	PROPN
fnp-3806	2825	2	.	.	PUNCT
fnp-3806	2825	3	a1	a1	NOUN
fnp-3806	2825	4	adenosine	adenosine	NOUN
fnp-3806	2825	5	receptors	receptor	NOUN
fnp-3806	2825	6	accumulate	accumulate	VERB
fnp-3806	2825	7	in	in	ADP
fnp-3806	2825	8	neurodegenerative	neurodegenerative	ADJ
fnp-3806	2825	9	structures	structure	NOUN
fnp-3806	2825	10	in	in	ADP
fnp-3806	2825	11	alzheimer	alzheimer	NOUN
fnp-3806	2825	12	disease	disease	NOUN
fnp-3806	2825	13	and	and	CCONJ
fnp-3806	2825	14	mediate	mediate	VERB
fnp-3806	2825	15	both	both	DET
fnp-3806	2825	16	amyloid	amyloid	NOUN
fnp-3806	2825	17	precursor	precursor	NOUN
fnp-3806	2825	18	protein	protein	NOUN
fnp-3806	2825	19	processing	processing	NOUN
fnp-3806	2825	20	and	and	CCONJ
fnp-3806	2825	21	tau	tau	PROPN
fnp-3806	2825	22	phosphorylation	phosphorylation	NOUN
fnp-3806	2825	23	and	and	CCONJ
fnp-3806	2825	24	translocation	translocation	NOUN
fnp-3806	2825	25	.	.	PUNCT
fnp-3806	2826	1	brain	brain	NOUN
fnp-3806	2826	2	pathol	pathol	NOUN
fnp-3806	2826	3	2003;13:440	2003;13:440	NOUN
fnp-3806	2826	4	-	-	SYM
fnp-3806	2826	5	451	451	NUM
fnp-3806	2826	6	.	.	PUNCT
fnp-3806	2827	1	https://doi.org/10.1111/j.1750-3639.2003.tb00475.x	https://doi.org/10.1111/j.1750-3639.2003.tb00475.x	PROPN
fnp-3806	2827	2	albasanz	albasanz	PROPN
fnp-3806	2827	3	jl	jl	PROPN
fnp-3806	2827	4	,	,	PUNCT
fnp-3806	2827	5	perez	perez	PROPN
fnp-3806	2827	6	s	s	PROPN
fnp-3806	2827	7	,	,	PUNCT
fnp-3806	2827	8	barrachina	barrachina	PROPN
fnp-3806	2827	9	m	m	PROPN
fnp-3806	2827	10	,	,	PUNCT
fnp-3806	2827	11	et	et	PROPN
fnp-3806	2827	12	al	al	PROPN
fnp-3806	2827	13	.	.	PROPN
fnp-3806	2828	1	up	up	ADP
fnp-3806	2828	2	-	-	PUNCT
fnp-3806	2828	3	regulation	regulation	NOUN
fnp-3806	2828	4	of	of	ADP
fnp-3806	2828	5	adenosine	adenosine	ADJ
fnp-3806	2828	6	receptors	receptor	NOUN
fnp-3806	2828	7	in	in	ADP
fnp-3806	2828	8	the	the	DET
fnp-3806	2828	9	frontal	frontal	ADJ
fnp-3806	2828	10	cortex	cortex	NOUN
fnp-3806	2828	11	in	in	ADP
fnp-3806	2828	12	alzheimer	alzheimer	PROPN
fnp-3806	2828	13	’s	’s	PART
fnp-3806	2828	14	disease	disease	NOUN
fnp-3806	2828	15	brain	brain	NOUN
fnp-3806	2828	16	pathology	pathology	NOUN
fnp-3806	2828	17	brain	brain	NOUN
fnp-3806	2828	18	pathol	pathol	NOUN
fnp-3806	2828	19	2008;18:211	2008;18:211	NOUN
fnp-3806	2828	20	-	-	SYM
fnp-3806	2828	21	219	219	NUM
fnp-3806	2828	22	.	.	PUNCT
fnp-3806	2829	1	https://doi.org/10.1111/j.1750-3639.2007.00112	https://doi.org/10.1111/j.1750-3639.2007.00112	PROPN
fnp-3806	2829	2	howlett	howlett	PROPN
fnp-3806	2829	3	ac	ac	PROPN
fnp-3806	2829	4	.	.	PUNCT
fnp-3806	2830	1	the	the	DET
fnp-3806	2830	2	cannabinoid	cannabinoid	NOUN
fnp-3806	2830	3	receptors	receptor	NOUN
fnp-3806	2830	4	.	.	PUNCT
fnp-3806	2831	1	prostaglandins	prostaglandin	VERB
fnp-3806	2831	2	other	other	ADJ
fnp-3806	2831	3	lipid	lipid	NOUN
fnp-3806	2831	4	mediat	mediat	PROPN
fnp-3806	2831	5	2002;68	2002;68	NUM
fnp-3806	2831	6	-	-	SYM
fnp-3806	2831	7	69	69	NUM
fnp-3806	2831	8	:	:	PUNCT
fnp-3806	2831	9	619	619	NUM
fnp-3806	2831	10	-	-	SYM
fnp-3806	2831	11	631	631	NUM
fnp-3806	2831	12	.	.	PUNCT
fnp-3806	2832	1	https://doi.org/10.1016/s0090-6980(02)00060-6	https://doi.org/10.1016/s0090-6980(02)00060-6	PROPN
fnp-3806	2832	2	devane	devane	PROPN
fnp-3806	2832	3	wa	wa	PROPN
fnp-3806	2832	4	,	,	PUNCT
fnp-3806	2832	5	axelrod	axelrod	PROPN
fnp-3806	2832	6	j.	j.	PROPN
fnp-3806	2832	7	enzymatic	enzymatic	ADJ
fnp-3806	2832	8	synthesis	synthesis	NOUN
fnp-3806	2832	9	of	of	ADP
fnp-3806	2832	10	anandamide	anandamide	NOUN
fnp-3806	2832	11	,	,	PUNCT
fnp-3806	2832	12	an	an	DET
fnp-3806	2832	13	endogenous	endogenous	ADJ
fnp-3806	2832	14	ligand	ligand	NOUN
fnp-3806	2832	15	for	for	ADP
fnp-3806	2832	16	the	the	DET
fnp-3806	2832	17	cannabinoid	cannabinoid	NOUN
fnp-3806	2832	18	receptor	receptor	NOUN
fnp-3806	2832	19	,	,	PUNCT
fnp-3806	2832	20	by	by	ADP
fnp-3806	2832	21	brain	brain	NOUN
fnp-3806	2832	22	membranes	membrane	NOUN
fnp-3806	2832	23	.	.	PUNCT
fnp-3806	2833	1	proc	proc	PROPN
fnp-3806	2833	2	natl	natl	PROPN
fnp-3806	2833	3	acad	acad	PROPN
fnp-3806	2833	4	sci	sci	PROPN
fnp-3806	2833	5	usa	usa	PROPN
fnp-3806	2833	6	1994;91:6698	1994;91:6698	PROPN
fnp-3806	2833	7	-	-	PUNCT
fnp-3806	2833	8	6701	6701	NUM
fnp-3806	2833	9	.	.	PUNCT
fnp-3806	2834	1	https://doi.org/10.1073/pnas.91.14.6698	https://doi.org/10.1073/pnas.91.14.6698	PROPN
fnp-3806	2834	2	sugiura	sugiura	PROPN
fnp-3806	2834	3	t	t	PROPN
fnp-3806	2834	4	,	,	PUNCT
fnp-3806	2834	5	waku	waku	PROPN
fnp-3806	2834	6	k.	k.	PROPN
fnp-3806	2834	7	2	2	NUM
fnp-3806	2834	8	-	-	PUNCT
fnp-3806	2834	9	arachidonoylglycerol	arachidonoylglycerol	NOUN
fnp-3806	2834	10	and	and	CCONJ
fnp-3806	2834	11	the	the	DET
fnp-3806	2834	12	cannabinoid	cannabinoid	NOUN
fnp-3806	2834	13	receptors	receptor	NOUN
fnp-3806	2834	14	.	.	PUNCT
fnp-3806	2835	1	chem	chem	NOUN
fnp-3806	2835	2	phys	phy	NOUN
fnp-3806	2835	3	lipids	lipid	VERB
fnp-3806	2835	4	2000;108:89	2000;108:89	NOUN
fnp-3806	2835	5	-	-	SYM
fnp-3806	2835	6	106	106	NUM
fnp-3806	2835	7	.	.	PUNCT
fnp-3806	2836	1	https://doi.org/10.1016/s0009-3084(00)00189-4	https://doi.org/10.1016/s0009-3084(00)00189-4	PROPN
fnp-3806	2836	2	sugiura	sugiura	PROPN
fnp-3806	2836	3	t	t	PROPN
fnp-3806	2836	4	,	,	PUNCT
fnp-3806	2836	5	waku	waku	PROPN
fnp-3806	2836	6	k.	k.	PROPN
fnp-3806	2836	7	cannabinoid	cannabinoid	PROPN
fnp-3806	2836	8	receptors	receptor	NOUN
fnp-3806	2836	9	and	and	CCONJ
fnp-3806	2836	10	their	their	PRON
fnp-3806	2836	11	endogenous	endogenous	ADJ
fnp-3806	2836	12	ligands	ligand	NOUN
fnp-3806	2836	13	.	.	PUNCT
fnp-3806	2837	1	j	j	PROPN
fnp-3806	2837	2	biochem	biochem	PROPN
fnp-3806	2837	3	2002	2002	NUM
fnp-3806	2837	4	;	;	PUNCT
fnp-3806	2837	5	132:7	132:7	NUM
fnp-3806	2837	6	-	-	SYM
fnp-3806	2837	7	12	12	NUM
fnp-3806	2837	8	.	.	PUNCT
fnp-3806	2838	1	https://doi.org/10.1093/oxfordjournals.jbchem.a003200	https://doi.org/10.1093/oxfordjournals.jbchem.a003200	PROPN
fnp-3806	2838	2	sugiura	sugiura	NOUN
fnp-3806	2838	3	t.	t.	NOUN
fnp-3806	2838	4	physiological	physiological	ADJ
fnp-3806	2838	5	roles	role	NOUN
fnp-3806	2838	6	of	of	ADP
fnp-3806	2838	7	2	2	NUM
fnp-3806	2838	8	-	-	PUNCT
fnp-3806	2838	9	arachidonoylglycerol	arachidonoylglycerol	NOUN
fnp-3806	2838	10	,	,	PUNCT
fnp-3806	2838	11	an	an	DET
fnp-3806	2838	12	endogenous	endogenous	ADJ
fnp-3806	2838	13	cannabinoid	cannabinoid	NOUN
fnp-3806	2838	14	receptor	receptor	NOUN
fnp-3806	2838	15	ligand	ligand	NOUN
fnp-3806	2838	16	.	.	PUNCT
fnp-3806	2839	1	biofactors	biofactor	NOUN
fnp-3806	2839	2	2009;35:88	2009;35:88	NUM
fnp-3806	2839	3	-	-	SYM
fnp-3806	2839	4	97	97	NUM
fnp-3806	2839	5	.	.	PUNCT
fnp-3806	2840	1	https://doi.org/10.1002/biof.18	https://doi.org/10.1002/biof.18	X
fnp-3806	2840	2	glass	glass	PROPN
fnp-3806	2840	3	m	m	PROPN
fnp-3806	2840	4	,	,	PUNCT
fnp-3806	2840	5	dragunow	dragunow	PROPN
fnp-3806	2840	6	m	m	PROPN
fnp-3806	2840	7	,	,	PUNCT
fnp-3806	2840	8	faull	faull	ADJ
fnp-3806	2840	9	rl	rl	X
fnp-3806	2840	10	.	.	PUNCT
fnp-3806	2840	11	cannabinoid	cannabinoid	NOUN
fnp-3806	2840	12	receptors	receptor	NOUN
fnp-3806	2840	13	in	in	ADP
fnp-3806	2840	14	the	the	DET
fnp-3806	2840	15	human	human	ADJ
fnp-3806	2840	16	brain	brain	NOUN
fnp-3806	2840	17	:	:	PUNCT
fnp-3806	2840	18	a	a	DET
fnp-3806	2840	19	detailed	detailed	ADJ
fnp-3806	2840	20	anatomical	anatomical	ADJ
fnp-3806	2840	21	and	and	CCONJ
fnp-3806	2840	22	quantitative	quantitative	ADJ
fnp-3806	2840	23	autoradiographic	autoradiographic	ADJ
fnp-3806	2840	24	study	study	NOUN
fnp-3806	2840	25	in	in	ADP
fnp-3806	2840	26	the	the	DET
fnp-3806	2840	27	fetal	fetal	ADJ
fnp-3806	2840	28	,	,	PUNCT
fnp-3806	2840	29	neonatal	neonatal	ADJ
fnp-3806	2840	30	and	and	CCONJ
fnp-3806	2840	31	adult	adult	NOUN
fnp-3806	2840	32	human	human	ADJ
fnp-3806	2840	33	brain	brain	NOUN
fnp-3806	2840	34	.	.	PUNCT
fnp-3806	2841	1	neuroscience	neuroscience	NOUN
fnp-3806	2841	2	1997;77:299	1997;77:299	NUM
fnp-3806	2841	3	-	-	SYM
fnp-3806	2841	4	318	318	NUM
fnp-3806	2841	5	.	.	PUNCT
fnp-3806	2842	1	https://doi.org/10.1016/s0306-4522(96)00428-9	https://doi.org/10.1016/s0306-4522(96)00428-9	PROPN
fnp-3806	2842	2	biegon	biegon	VERB
fnp-3806	2842	3	a	a	DET
fnp-3806	2842	4	,	,	PUNCT
fnp-3806	2842	5	kerman	kerman	PROPN
fnp-3806	2842	6	ia	ia	PROPN
fnp-3806	2842	7	.	.	PROPN
fnp-3806	2842	8	autoradiographic	autoradiographic	ADJ
fnp-3806	2842	9	study	study	NOUN
fnp-3806	2842	10	of	of	ADP
fnp-3806	2842	11	preand	preand	NOUN
fnp-3806	2842	12	postnatal	postnatal	ADJ
fnp-3806	2842	13	distribution	distribution	NOUN
fnp-3806	2842	14	of	of	ADP
fnp-3806	2842	15	cannabinoid	cannabinoid	NOUN
fnp-3806	2842	16	receptors	receptor	NOUN
fnp-3806	2842	17	in	in	ADP
fnp-3806	2842	18	human	human	ADJ
fnp-3806	2842	19	brain	brain	NOUN
fnp-3806	2842	20	.	.	PUNCT
fnp-3806	2843	1	neuroimage	neuroimage	NOUN
fnp-3806	2843	2	2001;14:1463	2001;14:1463	NUM
fnp-3806	2843	3	-	-	SYM
fnp-3806	2843	4	1468	1468	NUM
fnp-3806	2843	5	.	.	PUNCT
fnp-3806	2844	1	https://doi.org/10.1006/nimg.2001.0939	https://doi.org/10.1006/nimg.2001.0939	PROPN
fnp-3806	2844	2	katona	katona	PROPN
fnp-3806	2844	3	i	i	PROPN
fnp-3806	2844	4	,	,	PUNCT
fnp-3806	2844	5	rancz	rancz	PROPN
fnp-3806	2844	6	ea	ea	PROPN
fnp-3806	2844	7	,	,	PUNCT
fnp-3806	2844	8	acsady	acsady	PROPN
fnp-3806	2844	9	l	l	NOUN
fnp-3806	2844	10	,	,	PUNCT
fnp-3806	2844	11	et	et	PROPN
fnp-3806	2844	12	al	al	PROPN
fnp-3806	2844	13	.	.	PUNCT
fnp-3806	2844	14	distribution	distribution	NOUN
fnp-3806	2844	15	of	of	ADP
fnp-3806	2844	16	cb1	cb1	PROPN
fnp-3806	2844	17	cannabinoid	cannabinoid	NOUN
fnp-3806	2844	18	receptors	receptor	NOUN
fnp-3806	2844	19	in	in	ADP
fnp-3806	2844	20	the	the	DET
fnp-3806	2844	21	amygdala	amygdala	NOUN
fnp-3806	2844	22	and	and	CCONJ
fnp-3806	2844	23	their	their	PRON
fnp-3806	2844	24	role	role	NOUN
fnp-3806	2844	25	in	in	ADP
fnp-3806	2844	26	the	the	DET
fnp-3806	2844	27	control	control	NOUN
fnp-3806	2844	28	of	of	ADP
fnp-3806	2844	29	gabaergic	gabaergic	ADJ
fnp-3806	2844	30	transmission	transmission	NOUN
fnp-3806	2844	31	.	.	PUNCT
fnp-3806	2845	1	j	j	PROPN
fnp-3806	2845	2	neurosci	neurosci	PROPN
fnp-3806	2845	3	2001	2001	NUM
fnp-3806	2845	4	;	;	PUNCT
fnp-3806	2845	5	21	21	NUM
fnp-3806	2845	6	:	:	PUNCT
fnp-3806	2845	7	9506	9506	NUM
fnp-3806	2845	8	-	-	SYM
fnp-3806	2845	9	9518	9518	NUM
fnp-3806	2845	10	.	.	PUNCT
fnp-3806	2846	1	https://doi.org/10.1523/jneurosci.21-23-09506.2001	https://doi.org/10.1523/jneurosci.21-23-09506.2001	PROPN
fnp-3806	2846	2	katona	katona	PROPN
fnp-3806	2846	3	i	i	PROPN
fnp-3806	2846	4	,	,	PUNCT
fnp-3806	2846	5	urban	urban	PROPN
fnp-3806	2846	6	gm	gm	PROPN
fnp-3806	2846	7	,	,	PUNCT
fnp-3806	2846	8	wallace	wallace	PROPN
fnp-3806	2846	9	m	m	PROPN
fnp-3806	2846	10	,	,	PUNCT
fnp-3806	2846	11	et	et	PROPN
fnp-3806	2846	12	al	al	PROPN
fnp-3806	2846	13	.	.	PUNCT
fnp-3806	2847	1	molecular	molecular	ADJ
fnp-3806	2847	2	composition	composition	NOUN
fnp-3806	2847	3	of	of	ADP
fnp-3806	2847	4	the	the	DET
fnp-3806	2847	5	endocannabinoid	endocannabinoid	NOUN
fnp-3806	2847	6	system	system	NOUN
fnp-3806	2847	7	at	at	ADP
fnp-3806	2847	8	glutamatergic	glutamatergic	ADJ
fnp-3806	2847	9	synapses	synapsis	NOUN
fnp-3806	2847	10	.	.	PUNCT
fnp-3806	2848	1	j	j	PROPN
fnp-3806	2848	2	neurosci	neurosci	PROPN
fnp-3806	2848	3	2006	2006	NUM
fnp-3806	2848	4	;	;	PUNCT
fnp-3806	2848	5	26	26	NUM
fnp-3806	2848	6	:	:	SYM
fnp-3806	2848	7	5628	5628	NUM
fnp-3806	2848	8	-	-	SYM
fnp-3806	2848	9	5637	5637	NUM
fnp-3806	2848	10	.	.	PUNCT
fnp-3806	2849	1	https://doi.org/10.1523/jneurosci.0309-06.2006	https://doi.org/10.1523/jneurosci.0309-06.2006	ADJ
fnp-3806	2849	2	ohno	ohno	PROPN
fnp-3806	2849	3	-	-	PUNCT
fnp-3806	2849	4	shosaku	shosaku	PROPN
fnp-3806	2849	5	t	t	PROPN
fnp-3806	2849	6	,	,	PUNCT
fnp-3806	2849	7	tsubokawa	tsubokawa	NOUN
fnp-3806	2849	8	h	h	NOUN
fnp-3806	2849	9	,	,	PUNCT
fnp-3806	2849	10	mizushima	mizushima	PROPN
fnp-3806	2849	11	i	i	PROPN
fnp-3806	2849	12	,	,	PUNCT
fnp-3806	2849	13	et	et	PROPN
fnp-3806	2849	14	al	al	PROPN
fnp-3806	2849	15	.	.	PROPN
fnp-3806	2850	1	presynaptic	presynaptic	ADJ
fnp-3806	2850	2	cannabinoid	cannabinoid	NOUN
fnp-3806	2850	3	sensitivity	sensitivity	NOUN
fnp-3806	2850	4	is	be	AUX
fnp-3806	2850	5	a	a	DET
fnp-3806	2850	6	major	major	ADJ
fnp-3806	2850	7	determinant	determinant	NOUN
fnp-3806	2850	8	of	of	ADP
fnp-3806	2850	9	depolarization	depolarization	NOUN
fnp-3806	2850	10	-	-	PUNCT
fnp-3806	2850	11	induced	induce	VERB
fnp-3806	2850	12	retrograde	retrograde	ADJ
fnp-3806	2850	13	suppression	suppression	NOUN
fnp-3806	2850	14	at	at	ADP
fnp-3806	2850	15	hippocampal	hippocampal	ADJ
fnp-3806	2850	16	synapses	synapsis	NOUN
fnp-3806	2850	17	.	.	PUNCT
fnp-3806	2851	1	j	j	PROPN
fnp-3806	2851	2	neurosci	neurosci	PROPN
fnp-3806	2851	3	2002	2002	NUM
fnp-3806	2851	4	;	;	PUNCT
fnp-3806	2851	5	22:3864	22:3864	NUM
fnp-3806	2851	6	-	-	SYM
fnp-3806	2851	7	3872	3872	NUM
fnp-3806	2851	8	.	.	PUNCT
fnp-3806	2852	1	https://doi.org/10.1523/jneurosci.22-10-03864.2002	https://doi.org/10.1523/jneurosci.22-10-03864.2002	PROPN
fnp-3806	2852	2	wilson	wilson	PROPN
fnp-3806	2852	3	ri	ri	PROPN
fnp-3806	2852	4	,	,	PUNCT
fnp-3806	2852	5	kunos	kunos	PROPN
fnp-3806	2852	6	g	g	PROPN
fnp-3806	2852	7	,	,	PUNCT
fnp-3806	2852	8	nicoll	nicoll	PROPN
fnp-3806	2852	9	ra	ra	PROPN
fnp-3806	2852	10	.	.	PUNCT
fnp-3806	2853	1	presynaptic	presynaptic	ADJ
fnp-3806	2853	2	specificity	specificity	NOUN
fnp-3806	2853	3	of	of	ADP
fnp-3806	2853	4	endocannabinoid	endocannabinoid	NOUN
fnp-3806	2853	5	signaling	signal	VERB
fnp-3806	2853	6	in	in	ADP
fnp-3806	2853	7	the	the	DET
fnp-3806	2853	8	hippocampus	hippocampus	PROPN
fnp-3806	2853	9	.	.	PUNCT
fnp-3806	2854	1	neuron	neuron	PROPN
fnp-3806	2854	2	2001;31:453	2001;31:453	PROPN
fnp-3806	2854	3	-	-	SYM
fnp-3806	2854	4	462	462	NUM
fnp-3806	2854	5	.	.	PUNCT
fnp-3806	2855	1	https://doi.org/10.1016/s0896-6273(01)00372-5	https://doi.org/10.1016/s0896-6273(01)00372-5	PROPN
fnp-3806	2855	2	wilson	wilson	PROPN
fnp-3806	2855	3	ri	ri	PROPN
fnp-3806	2855	4	,	,	PUNCT
fnp-3806	2855	5	nicoll	nicoll	PROPN
fnp-3806	2855	6	ra	ra	PROPN
fnp-3806	2855	7	.	.	PUNCT
fnp-3806	2856	1	endocannabinoid	endocannabinoid	PROPN
fnp-3806	2856	2	signaling	signal	VERB
fnp-3806	2856	3	in	in	ADP
fnp-3806	2856	4	the	the	DET
fnp-3806	2856	5	brain	brain	NOUN
fnp-3806	2856	6	.	.	PUNCT
fnp-3806	2857	1	science	science	NOUN
fnp-3806	2857	2	2002	2002	NUM
fnp-3806	2857	3	;	;	PUNCT
fnp-3806	2857	4	296:678	296:678	NUM
fnp-3806	2857	5	-	-	PUNCT
fnp-3806	2857	6	682	682	NUM
fnp-3806	2857	7	.	.	PUNCT
fnp-3806	2858	1	https://doi.org/10.1126/science.1063545	https://doi.org/10.1126/science.1063545	PROPN
fnp-3806	2858	2	cabral	cabral	PROPN
fnp-3806	2858	3	ga	ga	PROPN
fnp-3806	2858	4	,	,	PUNCT
fnp-3806	2858	5	griffin	griffin	PROPN
fnp-3806	2858	6	-	-	PUNCT
fnp-3806	2858	7	thomas	thomas	PROPN
fnp-3806	2858	8	l.	l.	PROPN
fnp-3806	2858	9	emerging	emerge	VERB
fnp-3806	2858	10	role	role	NOUN
fnp-3806	2858	11	of	of	ADP
fnp-3806	2858	12	the	the	DET
fnp-3806	2858	13	cannabinoid	cannabinoid	NOUN
fnp-3806	2858	14	receptor	receptor	NOUN
fnp-3806	2858	15	cb2	cb2	PROPN
fnp-3806	2858	16	in	in	ADP
fnp-3806	2858	17	immune	immune	ADJ
fnp-3806	2858	18	regulation	regulation	NOUN
fnp-3806	2858	19	:	:	PUNCT
fnp-3806	2858	20	therapeutic	therapeutic	ADJ
fnp-3806	2858	21	prospects	prospect	NOUN
fnp-3806	2858	22	for	for	ADP
fnp-3806	2858	23	neuroinflammation	neuroinflammation	NOUN
fnp-3806	2858	24	.	.	PUNCT
fnp-3806	2859	1	expert	expert	PROPN
fnp-3806	2859	2	rev	rev	PROPN
fnp-3806	2859	3	mol	mol	ADP
fnp-3806	2859	4	med	med	PROPN
fnp-3806	2859	5	2009;11	2009;11	NOUN
fnp-3806	2859	6	:	:	PUNCT
fnp-3806	2859	7	e3	e3	NOUN
fnp-3806	2859	8	.	.	PUNCT
fnp-3806	2860	1	https://doi.org/10.1017/s1462399409000957	https://doi.org/10.1017/s1462399409000957	NUM
fnp-3806	2860	2	mecha	mecha	PROPN
fnp-3806	2860	3	m	m	PROPN
fnp-3806	2860	4	,	,	PUNCT
fnp-3806	2860	5	feliu	feliu	VERB
fnp-3806	2860	6	a	a	PRON
fnp-3806	2860	7	,	,	PUNCT
fnp-3806	2860	8	carrillo	carrillo	PROPN
fnp-3806	2860	9	-	-	PUNCT
fnp-3806	2860	10	salinas	salinas	PROPN
fnp-3806	2860	11	fj	fj	PROPN
fnp-3806	2860	12	,	,	PUNCT
fnp-3806	2860	13	et	et	PROPN
fnp-3806	2860	14	al	al	PROPN
fnp-3806	2860	15	.	.	PROPN
fnp-3806	2860	16	endocannabinoids	endocannabinoid	NOUN
fnp-3806	2860	17	drive	drive	VERB
fnp-3806	2860	18	the	the	DET
fnp-3806	2860	19	acquisition	acquisition	NOUN
fnp-3806	2860	20	of	of	ADP
fnp-3806	2860	21	an	an	DET
fnp-3806	2860	22	alternative	alternative	ADJ
fnp-3806	2860	23	phenotype	phenotype	NOUN
fnp-3806	2860	24	in	in	ADP
fnp-3806	2860	25	microglia	microglia	ADJ
fnp-3806	2860	26	.	.	PUNCT
fnp-3806	2861	1	brain	brain	NOUN
fnp-3806	2861	2	behav	behav	PROPN
fnp-3806	2861	3	immun	immun	PROPN
fnp-3806	2861	4	2015;49:233	2015;49:233	PROPN
fnp-3806	2861	5	-	-	SYM
fnp-3806	2861	6	245	245	NUM
fnp-3806	2861	7	.	.	PUNCT
fnp-3806	2862	1	https://doi.org/10.1016/j.bbi.2015.06.002	https://doi.org/10.1016/j.bbi.2015.06.002	PROPN
fnp-3806	2862	2	van	van	PROPN
fnp-3806	2862	3	sickle	sickle	PROPN
fnp-3806	2862	4	md	md	PROPN
fnp-3806	2862	5	,	,	PUNCT
fnp-3806	2862	6	duncan	duncan	PROPN
fnp-3806	2862	7	m	m	PROPN
fnp-3806	2862	8	,	,	PUNCT
fnp-3806	2862	9	kingsley	kingsley	PROPN
fnp-3806	2862	10	pj	pj	PROPN
fnp-3806	2862	11	,	,	PUNCT
fnp-3806	2862	12	et	et	PROPN
fnp-3806	2862	13	al	al	PROPN
fnp-3806	2862	14	.	.	PUNCT
fnp-3806	2862	15	identification	identification	NOUN
fnp-3806	2862	16	and	and	CCONJ
fnp-3806	2862	17	functional	functional	ADJ
fnp-3806	2862	18	characterization	characterization	NOUN
fnp-3806	2862	19	of	of	ADP
fnp-3806	2862	20	brainstem	brainstem	NOUN
fnp-3806	2862	21	cannabinoid	cannabinoid	NOUN
fnp-3806	2862	22	cb2	cb2	PROPN
fnp-3806	2862	23	receptors	receptor	NOUN
fnp-3806	2862	24	.	.	PUNCT
fnp-3806	2863	1	science	science	NOUN
fnp-3806	2863	2	2005;310	2005;310	NUM
fnp-3806	2863	3	:	:	PUNCT
fnp-3806	2863	4	329	329	NUM
fnp-3806	2863	5	-	-	SYM
fnp-3806	2863	6	332	332	NUM
fnp-3806	2863	7	.	.	PUNCT
fnp-3806	2864	1	https://doi.org/10.1126/science.1115740	https://doi.org/10.1126/science.1115740	PROPN
fnp-3806	2864	2	brusco	brusco	PROPN
fnp-3806	2864	3	a	a	X
fnp-3806	2864	4	,	,	PUNCT
fnp-3806	2864	5	tagliaferro	tagliaferro	PROPN
fnp-3806	2864	6	pa	pa	PROPN
fnp-3806	2864	7	,	,	PUNCT
fnp-3806	2864	8	saez	saez	PROPN
fnp-3806	2864	9	t	t	PROPN
fnp-3806	2864	10	,	,	PUNCT
fnp-3806	2864	11	et	et	PROPN
fnp-3806	2864	12	al	al	PROPN
fnp-3806	2864	13	.	.	PUNCT
fnp-3806	2865	1	ultrastructural	ultrastructural	ADJ
fnp-3806	2865	2	localization	localization	NOUN
fnp-3806	2865	3	of	of	ADP
fnp-3806	2865	4	neuronal	neuronal	ADJ
fnp-3806	2865	5	brain	brain	NOUN
fnp-3806	2865	6	cb2	cb2	NOUN
fnp-3806	2865	7	cannabinoid	cannabinoid	NOUN
fnp-3806	2865	8	receptors	receptor	NOUN
fnp-3806	2865	9	.	.	PUNCT
fnp-3806	2866	1	ann	ann	PROPN
fnp-3806	2866	2	ny	ny	PROPN
fnp-3806	2866	3	acad	acad	PROPN
fnp-3806	2866	4	sci	sci	PROPN
fnp-3806	2866	5	2008;1139:450	2008;1139:450	NUM
fnp-3806	2866	6	-	-	SYM
fnp-3806	2866	7	457	457	NUM
fnp-3806	2866	8	.	.	PUNCT
fnp-3806	2867	1	https://doi.org/10.1196/annals.1432.037	https://doi.org/10.1196/annals.1432.037	PROPN
fnp-3806	2867	2	onaivi	onaivi	NOUN
fnp-3806	2867	3	es	es	NOUN
fnp-3806	2867	4	,	,	PUNCT
fnp-3806	2867	5	ishiguro	ishiguro	PROPN
fnp-3806	2867	6	h	h	PROPN
fnp-3806	2867	7	,	,	PUNCT
fnp-3806	2867	8	gong	gong	PROPN
fnp-3806	2867	9	jp	jp	PROPN
fnp-3806	2867	10	,	,	PUNCT
fnp-3806	2867	11	et	et	PROPN
fnp-3806	2867	12	al	al	PROPN
fnp-3806	2867	13	.	.	PUNCT
fnp-3806	2868	1	functional	functional	ADJ
fnp-3806	2868	2	expression	expression	NOUN
fnp-3806	2868	3	of	of	ADP
fnp-3806	2868	4	brain	brain	NOUN
fnp-3806	2868	5	neuronal	neuronal	ADJ
fnp-3806	2868	6	cb2	cb2	PROPN
fnp-3806	2868	7	cannabinoid	cannabinoid	NOUN
fnp-3806	2868	8	receptors	receptor	NOUN
fnp-3806	2868	9	are	be	AUX
fnp-3806	2868	10	involved	involve	VERB
fnp-3806	2868	11	in	in	ADP
fnp-3806	2868	12	the	the	DET
fnp-3806	2868	13	effects	effect	NOUN
fnp-3806	2868	14	of	of	ADP
fnp-3806	2868	15	drugs	drug	NOUN
fnp-3806	2868	16	of	of	ADP
fnp-3806	2868	17	abuse	abuse	NOUN
fnp-3806	2868	18	and	and	CCONJ
fnp-3806	2868	19	in	in	ADP
fnp-3806	2868	20	depression	depression	NOUN
fnp-3806	2868	21	.	.	PUNCT
fnp-3806	2869	1	ann	ann	PROPN
fnp-3806	2869	2	ny	ny	PROPN
fnp-3806	2869	3	acad	acad	PROPN
fnp-3806	2869	4	sci	sci	PROPN
fnp-3806	2869	5	2008;1139	2008;1139	NUM
fnp-3806	2869	6	:	:	PUNCT
fnp-3806	2869	7	434	434	NUM
fnp-3806	2869	8	-	-	SYM
fnp-3806	2869	9	449	449	NUM
fnp-3806	2869	10	.	.	PUNCT
fnp-3806	2870	1	https://doi.org/10.1196/annals.1432.036	https://doi.org/10.1196/annals.1432.036	PROPN
fnp-3806	2870	2	maccarrone	maccarrone	PROPN
fnp-3806	2870	3	m	m	PROPN
fnp-3806	2870	4	,	,	PUNCT
fnp-3806	2870	5	dainese	dainese	PROPN
fnp-3806	2870	6	e	e	PROPN
fnp-3806	2870	7	,	,	PUNCT
fnp-3806	2870	8	oddi	oddi	ADJ
fnp-3806	2870	9	s.	s.	PROPN
fnp-3806	2870	10	intracellular	intracellular	ADJ
fnp-3806	2870	11	trafficking	trafficking	NOUN
fnp-3806	2870	12	of	of	ADP
fnp-3806	2870	13	anandamide	anandamide	NOUN
fnp-3806	2870	14	:	:	PUNCT
fnp-3806	2870	15	new	new	ADJ
fnp-3806	2870	16	concepts	concept	NOUN
fnp-3806	2870	17	for	for	ADP
fnp-3806	2870	18	signaling	signal	VERB
fnp-3806	2870	19	.	.	PUNCT
fnp-3806	2871	1	trends	trend	NOUN
fnp-3806	2871	2	biochem	biochem	PROPN
fnp-3806	2871	3	sci	sci	PROPN
fnp-3806	2871	4	2010	2010	NUM
fnp-3806	2871	5	;	;	PUNCT
fnp-3806	2871	6	35	35	NUM
fnp-3806	2871	7	:	:	PUNCT
fnp-3806	2871	8	601	601	NUM
fnp-3806	2871	9	-	-	NOUN
fnp-3806	2871	10	608	608	NUM
fnp-3806	2871	11	.	.	PUNCT
fnp-3806	2872	1	https://doi.org/10.1016/j.tibs.2010.05.008	https://doi.org/10.1016/j.tibs.2010.05.008	PROPN
fnp-3806	2872	2	pertwee	pertwee	PROPN
fnp-3806	2872	3	rg	rg	PROPN
fnp-3806	2872	4	,	,	PUNCT
fnp-3806	2872	5	howlett	howlett	PROPN
fnp-3806	2872	6	ac	ac	PROPN
fnp-3806	2872	7	,	,	PUNCT
fnp-3806	2872	8	abood	abood	VERB
fnp-3806	2872	9	me	i	PRON
fnp-3806	2872	10	,	,	PUNCT
fnp-3806	2872	11	et	et	PROPN
fnp-3806	2872	12	al	al	PROPN
fnp-3806	2872	13	.	.	PROPN
fnp-3806	2873	1	cannabinoid	cannabinoid	NOUN
fnp-3806	2873	2	receptors	receptor	NOUN
fnp-3806	2873	3	and	and	CCONJ
fnp-3806	2873	4	their	their	PRON
fnp-3806	2873	5	ligands	ligand	NOUN
fnp-3806	2873	6	:	:	PUNCT
fnp-3806	2873	7	beyond	beyond	ADP
fnp-3806	2873	8	cb1	cb1	NOUN
fnp-3806	2873	9	and	and	CCONJ
fnp-3806	2873	10	cb2	cb2	PROPN
fnp-3806	2873	11	.	.	PUNCT
fnp-3806	2874	1	pharmacol	pharmacol	PROPN
fnp-3806	2874	2	rev	rev	VERB
fnp-3806	2874	3	2010;62:588	2010;62:588	NOUN
fnp-3806	2874	4	-	-	SYM
fnp-3806	2874	5	631	631	NUM
fnp-3806	2874	6	.	.	PUNCT
fnp-3806	2875	1	https://doi.org/10.1124/pr.110.003004	https://doi.org/10.1124/pr.110.003004	ADP
fnp-3806	2875	2	aso	aso	PROPN
fnp-3806	2875	3	e	e	PROPN
fnp-3806	2875	4	,	,	PUNCT
fnp-3806	2875	5	ferrer	ferrer	PROPN
fnp-3806	2875	6	i.	i.	PROPN
fnp-3806	2875	7	cannabinoids	cannabinoid	NOUN
fnp-3806	2875	8	for	for	ADP
fnp-3806	2875	9	treatment	treatment	NOUN
fnp-3806	2875	10	of	of	ADP
fnp-3806	2875	11	alzheimer	alzheimer	PROPN
fnp-3806	2875	12	's	's	PART
fnp-3806	2875	13	disease	disease	NOUN
fnp-3806	2875	14	:	:	PUNCT
fnp-3806	2876	1	moving	move	VERB
fnp-3806	2876	2	toward	toward	ADP
fnp-3806	2876	3	the	the	DET
fnp-3806	2876	4	clinic	clinic	NOUN
fnp-3806	2876	5	.	.	PUNCT
fnp-3806	2877	1	front	front	ADJ
fnp-3806	2877	2	pharmacol	pharmacol	PROPN
fnp-3806	2877	3	2014;5:37	2014;5:37	NOUN
fnp-3806	2877	4	.	.	PUNCT
fnp-3806	2878	1	https://doi.org/10.3389/fphar.2014.00037	https://doi.org/10.3389/fphar.2014.00037	PROPN
fnp-3806	2878	2	ramírez	ramírez	NOUN
fnp-3806	2878	3	bg	bg	NOUN
fnp-3806	2878	4	,	,	PUNCT
fnp-3806	2878	5	blázquez	blázquez	NOUN
fnp-3806	2878	6	c	c	NOUN
fnp-3806	2878	7	,	,	PUNCT
fnp-3806	2878	8	gómez	gómez	NOUN
fnp-3806	2878	9	del	del	PROPN
fnp-3806	2878	10	pulgar	pulgar	PROPN
fnp-3806	2878	11	t	t	PROPN
fnp-3806	2878	12	,	,	PUNCT
fnp-3806	2878	13	et	et	PROPN
fnp-3806	2878	14	al	al	PROPN
fnp-3806	2878	15	.	.	PROPN
fnp-3806	2878	16	prevention	prevention	PROPN
fnp-3806	2878	17	of	of	ADP
fnp-3806	2878	18	alzheimer	alzheimer	PROPN
fnp-3806	2878	19	’s	’s	PART
fnp-3806	2878	20	disease	disease	NOUN
fnp-3806	2878	21	pathology	pathology	NOUN
fnp-3806	2878	22	by	by	ADP
fnp-3806	2878	23	cannabinoids	cannabinoid	NOUN
fnp-3806	2878	24	:	:	PUNCT
fnp-3806	2878	25	neuroprotection	neuroprotection	NOUN
fnp-3806	2878	26	mediated	mediate	VERB
fnp-3806	2878	27	by	by	ADP
fnp-3806	2878	28	blockade	blockade	NOUN
fnp-3806	2878	29	of	of	ADP
fnp-3806	2878	30	microglial	microglial	ADJ
fnp-3806	2878	31	activation	activation	NOUN
fnp-3806	2878	32	.	.	PUNCT
fnp-3806	2879	1	j	j	PROPN
fnp-3806	2879	2	neurosci	neurosci	PROPN
fnp-3806	2879	3	2005;25	2005;25	NOUN
fnp-3806	2879	4	:	:	PUNCT
fnp-3806	2879	5	1904	1904	NUM
fnp-3806	2879	6	-	-	SYM
fnp-3806	2879	7	1913	1913	NUM
fnp-3806	2879	8	.	.	PUNCT
fnp-3806	2880	1	https://doi.org/10.1523/jneurosci.4540-04.2005	https://doi.org/10.1523/jneurosci.4540-04.2005	PROPN
fnp-3806	2880	2	solas	solas	PROPN
fnp-3806	2880	3	m	m	PROPN
fnp-3806	2880	4	,	,	PUNCT
fnp-3806	2880	5	francis	francis	PROPN
fnp-3806	2880	6	pt	pt	PROPN
fnp-3806	2880	7	,	,	PUNCT
fnp-3806	2880	8	franco	franco	PROPN
fnp-3806	2880	9	r	r	PROPN
fnp-3806	2880	10	,	,	PUNCT
fnp-3806	2880	11	et	et	PROPN
fnp-3806	2880	12	al	al	PROPN
fnp-3806	2880	13	.	.	PUNCT
fnp-3806	2880	14	cb2	cb2	PROPN
fnp-3806	2880	15	receptor	receptor	NOUN
fnp-3806	2880	16	and	and	CCONJ
fnp-3806	2880	17	amyloid	amyloid	NOUN
fnp-3806	2880	18	pathology	pathology	NOUN
fnp-3806	2880	19	in	in	ADP
fnp-3806	2880	20	frontal	frontal	ADJ
fnp-3806	2880	21	cortex	cortex	NOUN
fnp-3806	2880	22	of	of	ADP
fnp-3806	2880	23	alzheimer	alzheimer	PROPN
fnp-3806	2880	24	’s	’s	PART
fnp-3806	2880	25	disease	disease	NOUN
fnp-3806	2880	26	patients	patient	NOUN
fnp-3806	2880	27	.	.	PUNCT
fnp-3806	2881	1	neurobiol	neurobiol	ADJ
fnp-3806	2881	2	aging	age	VERB
fnp-3806	2881	3	2013;34	2013;34	NUM
fnp-3806	2881	4	:	:	PUNCT
fnp-3806	2881	5	805	805	NUM
fnp-3806	2881	6	-	-	SYM
fnp-3806	2881	7	808	808	NUM
fnp-3806	2881	8	.	.	PUNCT
fnp-3806	2882	1	https://doi.org/10.1016/j.neurobiolaging	https://doi.org/10.1016/j.neurobiolage	VERB
fnp-3806	2882	2	2012.06.005	2012.06.005	PROPN
fnp-3806	2882	3	.	.	PUNCT
fnp-3806	2883	1	benito	benito	PROPN
fnp-3806	2883	2	c	c	PROPN
fnp-3806	2883	3	,	,	PUNCT
fnp-3806	2883	4	núñez	núñez	PROPN
fnp-3806	2883	5	e	e	NOUN
fnp-3806	2883	6	,	,	PUNCT
fnp-3806	2883	7	tolón	tolón	PROPN
fnp-3806	2883	8	rm	rm	PROPN
fnp-3806	2883	9	,	,	PUNCT
fnp-3806	2883	10	et	et	PROPN
fnp-3806	2883	11	al	al	PROPN
fnp-3806	2883	12	.	.	PUNCT
fnp-3806	2883	13	cannabinoid	cannabinoid	PROPN
fnp-3806	2883	14	cb2	cb2	PROPN
fnp-3806	2883	15	receptors	receptor	NOUN
fnp-3806	2883	16	and	and	CCONJ
fnp-3806	2883	17	fatty	fatty	NOUN
fnp-3806	2883	18	acid	acid	NOUN
fnp-3806	2883	19	amide	amide	NOUN
fnp-3806	2883	20	hydrolase	hydrolase	NOUN
fnp-3806	2883	21	are	be	AUX
fnp-3806	2883	22	selectively	selectively	ADV
fnp-3806	2883	23	overexpressed	overexpresse	VERB
fnp-3806	2883	24	in	in	ADP
fnp-3806	2883	25	neuritic	neuritic	ADJ
fnp-3806	2883	26	plaque	plaque	NOUN
fnp-3806	2883	27	-	-	PUNCT
fnp-3806	2883	28	associated	associate	VERB
fnp-3806	2883	29	glia	glia	NOUN
fnp-3806	2883	30	in	in	ADP
fnp-3806	2883	31	alzheimer	alzheimer	PROPN
fnp-3806	2883	32	’s	’s	PART
fnp-3806	2883	33	disease	disease	NOUN
fnp-3806	2883	34	brains	brain	VERB
fnp-3806	2883	35	.	.	PUNCT
fnp-3806	2884	1	j	j	PROPN
fnp-3806	2884	2	neurosci	neurosci	PROPN
fnp-3806	2884	3	2003;23:11136	2003;23:11136	PROPN
fnp-3806	2884	4	-	-	SYM
fnp-3806	2884	5	11141	11141	NUM
fnp-3806	2884	6	.	.	PUNCT
fnp-3806	2885	1	https://doi.org/10.1523/jneurosci.23-35-11136.2003	https://doi.org/10.1523/jneurosci.23-35-11136.2003	PROPN
fnp-3806	2885	2	mulder	mulder	PROPN
fnp-3806	2885	3	j	j	PROPN
fnp-3806	2885	4	,	,	PUNCT
fnp-3806	2885	5	zilberter	zilberter	PROPN
fnp-3806	2885	6	m	m	PROPN
fnp-3806	2885	7	,	,	PUNCT
fnp-3806	2885	8	pasquare	pasquare	NOUN
fnp-3806	2885	9	sj	sj	PROPN
fnp-3806	2885	10	,	,	PUNCT
fnp-3806	2885	11	et	et	PROPN
fnp-3806	2885	12	al	al	PROPN
fnp-3806	2885	13	.	.	PUNCT
fnp-3806	2886	1	molecular	molecular	ADJ
fnp-3806	2886	2	reorganization	reorganization	NOUN
fnp-3806	2886	3	of	of	ADP
fnp-3806	2886	4	endocannabinoid	endocannabinoid	NOUN
fnp-3806	2886	5	signalling	signal	VERB
fnp-3806	2886	6	in	in	ADP
fnp-3806	2886	7	alzheimer	alzheimer	PROPN
fnp-3806	2886	8	’s	’s	PART
fnp-3806	2886	9	disease	disease	NOUN
fnp-3806	2886	10	.	.	PUNCT
fnp-3806	2887	1	brain	brain	NOUN
fnp-3806	2887	2	2011;134	2011;134	NUM
fnp-3806	2887	3	:	:	PUNCT
fnp-3806	2887	4	1041	1041	NUM
fnp-3806	2887	5	-	-	SYM
fnp-3806	2887	6	1060	1060	NUM
fnp-3806	2887	7	.	.	PUNCT
fnp-3806	2888	1	https://doi.org/10.1093/brain/awr046	https://doi.org/10.1093/brain/awr046	PROPN
fnp-3806	2888	2	jung	jung	PROPN
fnp-3806	2888	3	km	km	PROPN
fnp-3806	2888	4	,	,	PUNCT
fnp-3806	2888	5	astarita	astarita	PROPN
fnp-3806	2888	6	g	g	PROPN
fnp-3806	2888	7	,	,	PUNCT
fnp-3806	2888	8	yasar	yasar	PROPN
fnp-3806	2888	9	s	s	PROPN
fnp-3806	2888	10	,	,	PUNCT
fnp-3806	2888	11	et	et	PROPN
fnp-3806	2888	12	al	al	PROPN
fnp-3806	2888	13	.	.	PUNCT
fnp-3806	2889	1	an	an	DET
fnp-3806	2889	2	amyloid	amyloid	NOUN
fnp-3806	2889	3	β42	β42	NOUN
fnp-3806	2889	4	-	-	PUNCT
fnp-3806	2889	5	dependent	dependent	ADJ
fnp-3806	2889	6	deficit	deficit	NOUN
fnp-3806	2889	7	in	in	ADP
fnp-3806	2889	8	anandamide	anandamide	NOUN
fnp-3806	2889	9	mobilization	mobilization	NOUN
fnp-3806	2889	10	is	be	AUX
fnp-3806	2889	11	associated	associate	VERB
fnp-3806	2889	12	with	with	ADP
fnp-3806	2889	13	cognitive	cognitive	ADJ
fnp-3806	2889	14	dysfunction	dysfunction	NOUN
fnp-3806	2889	15	in	in	ADP
fnp-3806	2889	16	alzheimer	alzheimer	PROPN
fnp-3806	2889	17	’s	’s	PART
fnp-3806	2889	18	disease	disease	NOUN
fnp-3806	2889	19	.	.	PUNCT
fnp-3806	2890	1	neurobiol	neurobiol	PROPN
fnp-3806	2890	2	aging	age	VERB
fnp-3806	2890	3	2012;33	2012;33	PROPN
fnp-3806	2890	4	:	:	PUNCT
fnp-3806	2890	5	1522	1522	NUM
fnp-3806	2890	6	-	-	SYM
fnp-3806	2890	7	1532	1532	NUM
fnp-3806	2890	8	.	.	PUNCT
fnp-3806	2891	1	https://doi.org/10.1016/j.neurobiolaging.2011.03.012	https://doi.org/10.1016/j.neurobiolaging.2011.03.012	PROPN
fnp-3806	2891	2	hock	hock	NOUN
fnp-3806	2891	3	c	c	PROPN
fnp-3806	2891	4	,	,	PUNCT
fnp-3806	2891	5	heese	heese	PROPN
fnp-3806	2891	6	k	k	NOUN
fnp-3806	2891	7	,	,	PUNCT
fnp-3806	2891	8	hulette	hulette	PROPN
fnp-3806	2891	9	c	c	PROPN
fnp-3806	2891	10	,	,	PUNCT
fnp-3806	2891	11	et	et	PROPN
fnp-3806	2891	12	al	al	PROPN
fnp-3806	2891	13	.	.	PUNCT
fnp-3806	2891	14	region	region	NOUN
fnp-3806	2891	15	-	-	PUNCT
fnp-3806	2891	16	specific	specific	ADJ
fnp-3806	2891	17	neurotrophin	neurotrophin	ADJ
fnp-3806	2891	18	imbalances	imbalance	NOUN
fnp-3806	2891	19	in	in	ADP
fnp-3806	2891	20	alzheimer	alzheimer	PROPN
fnp-3806	2891	21	disease	disease	PROPN
fnp-3806	2891	22	:	:	PUNCT
fnp-3806	2891	23	decreased	decrease	VERB
fnp-3806	2891	24	levels	level	NOUN
fnp-3806	2891	25	of	of	ADP
fnp-3806	2891	26	brain	brain	NOUN
fnp-3806	2891	27	-	-	PUNCT
fnp-3806	2891	28	derived	derive	VERB
fnp-3806	2891	29	neurotrophic	neurotrophic	ADJ
fnp-3806	2891	30	factor	factor	NOUN
fnp-3806	2891	31	and	and	CCONJ
fnp-3806	2891	32	increased	increase	VERB
fnp-3806	2891	33	levels	level	NOUN
fnp-3806	2891	34	of	of	ADP
fnp-3806	2891	35	nerve	nerve	NOUN
fnp-3806	2891	36	growth	growth	NOUN
fnp-3806	2891	37	factor	factor	NOUN
fnp-3806	2891	38	in	in	ADP
fnp-3806	2891	39	hippocampus	hippocampus	NOUN
fnp-3806	2891	40	and	and	CCONJ
fnp-3806	2891	41	cortical	cortical	ADJ
fnp-3806	2891	42	areas	area	NOUN
fnp-3806	2891	43	.	.	PUNCT
fnp-3806	2892	1	arch	arch	ADJ
fnp-3806	2892	2	neurol	neurol	NOUN
fnp-3806	2892	3	2000;57:846	2000;57:846	NUM
fnp-3806	2892	4	-	-	SYM
fnp-3806	2892	5	851	851	NUM
fnp-3806	2892	6	.	.	PUNCT
fnp-3806	2893	1	https://doi.org/10.1001/archneur.57.6.846	https://doi.org/10.1001/archneur.57.6.846	ADJ
fnp-3806	2893	2	garzon	garzon	PROPN
fnp-3806	2893	3	d	d	PROPN
fnp-3806	2893	4	,	,	PUNCT
fnp-3806	2893	5	yu	yu	PROPN
fnp-3806	2893	6	g	g	PROPN
fnp-3806	2893	7	,	,	PUNCT
fnp-3806	2893	8	fahnestock	fahnestock	PROPN
fnp-3806	2893	9	m.	m.	NOUN
fnp-3806	2893	10	a	a	DET
fnp-3806	2893	11	new	new	ADJ
fnp-3806	2893	12	brain	brain	NOUN
fnp-3806	2893	13	-	-	PUNCT
fnp-3806	2893	14	derived	derive	VERB
fnp-3806	2893	15	neurotrophic	neurotrophic	ADJ
fnp-3806	2893	16	factor	factor	NOUN
fnp-3806	2893	17	transcript	transcript	NOUN
fnp-3806	2893	18	and	and	CCONJ
fnp-3806	2893	19	decrease	decrease	NOUN
fnp-3806	2893	20	in	in	ADP
fnp-3806	2893	21	brain	brain	NOUN
fnp-3806	2893	22	-	-	PUNCT
fnp-3806	2893	23	derived	derive	VERB
fnp-3806	2893	24	neurotrophic	neurotrophic	ADJ
fnp-3806	2893	25	factor	factor	NOUN
fnp-3806	2893	26	transcripts	transcript	NOUN
fnp-3806	2893	27	1	1	NUM
fnp-3806	2893	28	,	,	PUNCT
fnp-3806	2893	29	2	2	NUM
fnp-3806	2893	30	and	and	CCONJ
fnp-3806	2893	31	3	3	NUM
fnp-3806	2893	32	in	in	ADP
fnp-3806	2893	33	alzheimer	alzheimer	PROPN
fnp-3806	2893	34	’s	’s	PART
fnp-3806	2893	35	disease	disease	NOUN
fnp-3806	2893	36	parietal	parietal	ADJ
fnp-3806	2893	37	cortex	cortex	NOUN
fnp-3806	2893	38	.	.	PUNCT
fnp-3806	2894	1	j	j	PROPN
fnp-3806	2894	2	neurochem	neurochem	PROPN
fnp-3806	2894	3	2002	2002	NUM
fnp-3806	2894	4	;	;	PUNCT
fnp-3806	2894	5	82	82	NUM
fnp-3806	2894	6	:	:	SYM
fnp-3806	2894	7	1058	1058	NUM
fnp-3806	2894	8	-	-	SYM
fnp-3806	2894	9	1064	1064	NUM
fnp-3806	2894	10	.	.	PUNCT
fnp-3806	2895	1	https://doi.org/10.1046/j.1471-4159.2002.01030.x	https://doi.org/10.1046/j.1471-4159.2002.01030.x	PROPN
fnp-3806	2895	2	budni	budni	PROPN
fnp-3806	2895	3	j	j	PROPN
fnp-3806	2895	4	,	,	PUNCT
fnp-3806	2895	5	bellettini	bellettini	NOUN
fnp-3806	2895	6	-	-	PUNCT
fnp-3806	2895	7	santos	santos	NUM
fnp-3806	2895	8	t	t	PROPN
fnp-3806	2895	9	,	,	PUNCT
fnp-3806	2895	10	mina	mina	PROPN
fnp-3806	2896	1	f	f	PROPN
fnp-3806	2896	2	,	,	PUNCT
fnp-3806	2896	3	et	et	PROPN
fnp-3806	2896	4	al	al	PROPN
fnp-3806	2896	5	.	.	PUNCT
fnp-3806	2897	1	the	the	DET
fnp-3806	2897	2	involvement	involvement	NOUN
fnp-3806	2897	3	of	of	ADP
fnp-3806	2897	4	bdnf	bdnf	PROPN
fnp-3806	2897	5	,	,	PUNCT
fnp-3806	2897	6	ngf	ngf	ADV
fnp-3806	2897	7	and	and	CCONJ
fnp-3806	2897	8	gdnf	gdnf	ADJ
fnp-3806	2897	9	in	in	ADP
fnp-3806	2897	10	aging	aging	NOUN
fnp-3806	2897	11	and	and	CCONJ
fnp-3806	2897	12	alzheimer	alzheimer	NOUN
fnp-3806	2897	13	's	's	PART
fnp-3806	2897	14	disease	disease	NOUN
fnp-3806	2897	15	.	.	PUNCT
fnp-3806	2898	1	aging	age	VERB
fnp-3806	2898	2	dis	dis	PROPN
fnp-3806	2898	3	2015;6:331	2015;6:331	PROPN
fnp-3806	2898	4	-	-	PUNCT
fnp-3806	2898	5	341	341	NUM
fnp-3806	2898	6	.	.	PUNCT
fnp-3806	2899	1	https://doi.org/10.14336/ad.2015.0825	https://doi.org/10.14336/ad.2015.0825	PROPN
fnp-3806	2899	2	mohammadi	mohammadi	PROPN
fnp-3806	2899	3	a	a	PRON
fnp-3806	2899	4	,	,	PUNCT
fnp-3806	2899	5	ghasem	ghasem	PROPN
fnp-3806	2899	6	amooeian	amooeian	PROPN
fnp-3806	2899	7	v	v	PROPN
fnp-3806	2899	8	,	,	PUNCT
fnp-3806	2899	9	rashidi	rashidi	PROPN
fnp-3806	2899	10	e.	e.	PROPN
fnp-3806	2899	11	dysfunction	dysfunction	PROPN
fnp-3806	2899	12	in	in	ADP
fnp-3806	2899	13	brain	brain	NOUN
fnp-3806	2899	14	-	-	PUNCT
fnp-3806	2899	15	derived	derive	VERB
fnp-3806	2899	16	neurotrophic	neurotrophic	ADJ
fnp-3806	2899	17	factor	factor	NOUN
fnp-3806	2899	18	signaling	signal	VERB
fnp-3806	2899	19	pathway	pathway	NOUN
fnp-3806	2899	20	and	and	CCONJ
fnp-3806	2899	21	susceptibility	susceptibility	NOUN
fnp-3806	2899	22	to	to	ADP
fnp-3806	2899	23	schizophrenia	schizophrenia	NOUN
fnp-3806	2899	24	,	,	PUNCT
fnp-3806	2899	25	parkinson	parkinson	NOUN
fnp-3806	2899	26	's	's	PART
fnp-3806	2899	27	and	and	CCONJ
fnp-3806	2899	28	alzheimer	alzheimer	PROPN
fnp-3806	2899	29	's	's	PART
fnp-3806	2899	30	diseases	disease	NOUN
fnp-3806	2899	31	.	.	PUNCT
fnp-3806	2900	1	curr	curr	PROPN
fnp-3806	2900	2	gene	gene	PROPN
fnp-3806	2900	3	ther	ther	ADV
fnp-3806	2900	4	2018;18:45	2018;18:45	NUM
fnp-3806	2900	5	-	-	SYM
fnp-3806	2900	6	63	63	NUM
fnp-3806	2900	7	.	.	PUNCT
fnp-3806	2901	1	https://doi.org/10.2174/1566523218666180302163029	https://doi.org/10.2174/1566523218666180302163029	PROPN
fnp-3806	2901	2	numakawa	numakawa	PROPN
fnp-3806	2901	3	t	t	PROPN
fnp-3806	2901	4	,	,	PUNCT
fnp-3806	2901	5	odaka	odaka	NOUN
fnp-3806	2901	6	h.	h.	PROPN
fnp-3806	2901	7	brain	brain	PROPN
fnp-3806	2901	8	-	-	PUNCT
fnp-3806	2901	9	derived	derive	VERB
fnp-3806	2901	10	neurotrophic	neurotrophic	ADJ
fnp-3806	2901	11	factor	factor	NOUN
fnp-3806	2901	12	signaling	signal	VERB
fnp-3806	2901	13	in	in	ADP
fnp-3806	2901	14	the	the	DET
fnp-3806	2901	15	pathophysiology	pathophysiology	NOUN
fnp-3806	2901	16	of	of	ADP
fnp-3806	2901	17	alzheimer	alzheimer	PROPN
fnp-3806	2901	18	's	's	PART
fnp-3806	2901	19	disease	disease	NOUN
fnp-3806	2901	20	:	:	PUNCT
fnp-3806	2901	21	beneficial	beneficial	ADJ
fnp-3806	2901	22	effects	effect	NOUN
fnp-3806	2901	23	of	of	ADP
fnp-3806	2901	24	flavonoids	flavonoid	NOUN
fnp-3806	2901	25	for	for	ADP
fnp-3806	2901	26	neuroprotection	neuroprotection	NOUN
fnp-3806	2901	27	.	.	PUNCT
fnp-3806	2902	1	int	int	PROPN
fnp-3806	2902	2	j	j	PROPN
fnp-3806	2902	3	mol	mol	ADP
fnp-3806	2902	4	sci	sci	PROPN
fnp-3806	2902	5	2021;22:5719	2021;22:5719	NUM
fnp-3806	2902	6	.	.	PUNCT
fnp-3806	2903	1	https://doi.org/10.3390/ijms22115719	https://doi.org/10.3390/ijms22115719	PROPN
fnp-3806	2903	2	phillips	phillips	PROPN
fnp-3806	2903	3	hs	hs	PROPN
fnp-3806	2903	4	,	,	PUNCT
fnp-3806	2903	5	hains	hain	VERB
fnp-3806	2903	6	jm	jm	PROPN
fnp-3806	2903	7	,	,	PUNCT
fnp-3806	2903	8	armanini	armanini	PROPN
fnp-3806	2903	9	m	m	PROPN
fnp-3806	2903	10	,	,	PUNCT
fnp-3806	2903	11	et	et	PROPN
fnp-3806	2903	12	al	al	PROPN
fnp-3806	2903	13	.	.	PROPN
fnp-3806	2904	1	bdnf	bdnf	PROPN
fnp-3806	2904	2	mrna	mrna	PROPN
fnp-3806	2904	3	is	be	AUX
fnp-3806	2904	4	decreased	decrease	VERB
fnp-3806	2904	5	in	in	ADP
fnp-3806	2904	6	the	the	DET
fnp-3806	2904	7	hippocampus	hippocampus	NOUN
fnp-3806	2904	8	of	of	ADP
fnp-3806	2904	9	individuals	individual	NOUN
fnp-3806	2904	10	with	with	ADP
fnp-3806	2904	11	alzheimer	alzheimer	PROPN
fnp-3806	2904	12	’s	’s	PART
fnp-3806	2904	13	disease	disease	NOUN
fnp-3806	2904	14	.	.	PUNCT
fnp-3806	2905	1	neuron	neuron	PROPN
fnp-3806	2905	2	1991;7:695	1991;7:695	PROPN
fnp-3806	2905	3	-	-	PUNCT
fnp-3806	2905	4	702	702	NUM
fnp-3806	2905	5	.	.	PUNCT
fnp-3806	2906	1	https://doi.org/10.1016/0896-6273(91)90273-3	https://doi.org/10.1016/0896-6273(91)90273-3	PROPN
fnp-3806	2906	2	ferrer	ferrer	PROPN
fnp-3806	2906	3	i	i	PROPN
fnp-3806	2906	4	,	,	PUNCT
fnp-3806	2906	5	marín	marín	PROPN
fnp-3806	2906	6	c	c	PROPN
fnp-3806	2906	7	,	,	PUNCT
fnp-3806	2906	8	rey	rey	PROPN
fnp-3806	2906	9	mj	mj	PROPN
fnp-3806	2906	10	,	,	PUNCT
fnp-3806	2906	11	et	et	PROPN
fnp-3806	2906	12	al	al	PROPN
fnp-3806	2906	13	.	.	PROPN
fnp-3806	2906	14	bdnf	bdnf	PROPN
fnp-3806	2906	15	and	and	CCONJ
fnp-3806	2906	16	full	full	ADJ
fnp-3806	2906	17	-	-	PUNCT
fnp-3806	2906	18	length	length	NOUN
fnp-3806	2906	19	and	and	CCONJ
fnp-3806	2906	20	truncated	truncated	ADJ
fnp-3806	2906	21	trkb	trkb	NOUN
fnp-3806	2906	22	expression	expression	NOUN
fnp-3806	2906	23	in	in	ADP
fnp-3806	2906	24	alzheimer	alzheimer	PROPN
fnp-3806	2906	25	disease	disease	PROPN
fnp-3806	2906	26	:	:	PUNCT
fnp-3806	2906	27	implications	implication	NOUN
fnp-3806	2906	28	in	in	ADP
fnp-3806	2906	29	therapeutic	therapeutic	ADJ
fnp-3806	2906	30	strategies	strategy	NOUN
fnp-3806	2906	31	.	.	PUNCT
fnp-3806	2907	1	j	j	PROPN
fnp-3806	2907	2	neuropathol	neuropathol	PROPN
fnp-3806	2907	3	exp	exp	PROPN
fnp-3806	2907	4	neurol	neurol	PROPN
fnp-3806	2907	5	1999;58:729	1999;58:729	NUM
fnp-3806	2907	6	-	-	SYM
fnp-3806	2907	7	739	739	NUM
fnp-3806	2907	8	.	.	PUNCT
fnp-3806	2908	1	https://doi.org/10.1097/00005072-199907000-00007	https://doi.org/10.1097/00005072-199907000-00007	PROPN
fnp-3806	2908	2	holsinger	holsinger	PROPN
fnp-3806	2908	3	rm	rm	PROPN
fnp-3806	2908	4	,	,	PUNCT
fnp-3806	2908	5	schnarr	schnarr	PROPN
fnp-3806	2908	6	j	j	PROPN
fnp-3806	2908	7	,	,	PUNCT
fnp-3806	2908	8	henry	henry	PROPN
fnp-3806	2908	9	p	p	PROPN
fnp-3806	2908	10	,	,	PUNCT
fnp-3806	2908	11	et	et	PROPN
fnp-3806	2908	12	al	al	PROPN
fnp-3806	2908	13	.	.	PUNCT
fnp-3806	2908	14	quantitation	quantitation	PROPN
fnp-3806	2908	15	of	of	ADP
fnp-3806	2908	16	bdnf	bdnf	PROPN
fnp-3806	2908	17	mrna	mrna	PROPN
fnp-3806	2908	18	in	in	ADP
fnp-3806	2908	19	human	human	ADJ
fnp-3806	2908	20	parietal	parietal	ADJ
fnp-3806	2908	21	cortex	cortex	NOUN
fnp-3806	2908	22	by	by	ADP
fnp-3806	2908	23	competitive	competitive	ADJ
fnp-3806	2908	24	reverse	reverse	ADJ
fnp-3806	2908	25	transcription	transcription	NOUN
fnp-3806	2908	26	-	-	PUNCT
fnp-3806	2908	27	polymerase	polymerase	NOUN
fnp-3806	2908	28	chain	chain	NOUN
fnp-3806	2908	29	reaction	reaction	NOUN
fnp-3806	2908	30	:	:	PUNCT
fnp-3806	2908	31	decreased	decrease	VERB
fnp-3806	2908	32	levels	level	NOUN
fnp-3806	2908	33	in	in	ADP
fnp-3806	2908	34	alzheimer	alzheimer	PROPN
fnp-3806	2908	35	's	's	PART
fnp-3806	2908	36	disease	disease	NOUN
fnp-3806	2908	37	.	.	PUNCT
fnp-3806	2909	1	brain	brain	NOUN
fnp-3806	2909	2	res	re	NOUN
fnp-3806	2909	3	mol	mol	ADP
fnp-3806	2909	4	brain	brain	NOUN
fnp-3806	2909	5	res	re	NOUN
fnp-3806	2909	6	2000;76:347	2000;76:347	PROPN
fnp-3806	2909	7	-	-	SYM
fnp-3806	2909	8	354	354	NUM
fnp-3806	2909	9	.	.	PUNCT
fnp-3806	2910	1	https://doi.org/10.1016/s0169-328x(00)00023-1	https://doi.org/10.1016/s0169-328x(00)00023-1	PROPN
fnp-3806	2910	2	wong	wong	PROPN
fnp-3806	2910	3	j	j	PROPN
fnp-3806	2910	4	,	,	PUNCT
fnp-3806	2910	5	higgins	higgins	PROPN
fnp-3806	2910	6	m	m	PROPN
fnp-3806	2910	7	,	,	PUNCT
fnp-3806	2910	8	halliday	halliday	PROPN
fnp-3806	2910	9	g	g	PROPN
fnp-3806	2910	10	,	,	PUNCT
fnp-3806	2910	11	et	et	PROPN
fnp-3806	2910	12	al	al	PROPN
fnp-3806	2910	13	.	.	PUNCT
fnp-3806	2911	1	amyloid	amyloid	PROPN
fnp-3806	2911	2	beta	beta	NOUN
fnp-3806	2911	3	selectively	selectively	ADV
fnp-3806	2911	4	modulates	modulate	VERB
fnp-3806	2911	5	neuronal	neuronal	ADJ
fnp-3806	2911	6	trkb	trkb	NOUN
fnp-3806	2911	7	alternative	alternative	ADJ
fnp-3806	2911	8	transcript	transcript	NOUN
fnp-3806	2911	9	expression	expression	NOUN
fnp-3806	2911	10	with	with	ADP
fnp-3806	2911	11	implications	implication	NOUN
fnp-3806	2911	12	for	for	ADP
fnp-3806	2911	13	alzheimer	alzheimer	PROPN
fnp-3806	2911	14	's	's	PART
fnp-3806	2911	15	disease	disease	NOUN
fnp-3806	2911	16	.	.	PUNCT
fnp-3806	2912	1	neuroscience	neuroscience	NOUN
fnp-3806	2912	2	2012;210:363	2012;210:363	NUM
fnp-3806	2912	3	-	-	SYM
fnp-3806	2912	4	374	374	NUM
fnp-3806	2912	5	.	.	PUNCT
fnp-3806	2913	1	https://doi.org/10.1016/j.neuroscience.2012.02.037	https://doi.org/10.1016/j.neuroscience.2012.02.037	NUM
fnp-3806	2913	2	fleitas	fleita	NOUN
fnp-3806	2913	3	c	c	NOUN
fnp-3806	2913	4	,	,	PUNCT
fnp-3806	2913	5	piñol	piñol	NOUN
fnp-3806	2913	6	-	-	PUNCT
fnp-3806	2913	7	ripoll	ripoll	NOUN
fnp-3806	2913	8	g	g	NOUN
fnp-3806	2913	9	,	,	PUNCT
fnp-3806	2913	10	marfull	marfull	NOUN
fnp-3806	2913	11	p	p	NOUN
fnp-3806	2913	12	,	,	PUNCT
fnp-3806	2913	13	et	et	PROPN
fnp-3806	2913	14	al	al	PROPN
fnp-3806	2913	15	.	.	PROPN
fnp-3806	2913	16	probdnf	probdnf	PROPN
fnp-3806	2913	17	is	be	AUX
fnp-3806	2913	18	modified	modify	VERB
fnp-3806	2913	19	by	by	ADP
fnp-3806	2913	20	advanced	advanced	ADJ
fnp-3806	2913	21	glycation	glycation	NOUN
fnp-3806	2913	22	end	end	NOUN
fnp-3806	2913	23	-	-	PUNCT
fnp-3806	2913	24	products	product	NOUN
fnp-3806	2913	25	in	in	ADP
fnp-3806	2913	26	alzheimer	alzheimer	PROPN
fnp-3806	2913	27	’s	’s	PART
fnp-3806	2913	28	disease	disease	NOUN
fnp-3806	2913	29	,	,	PUNCT
fnp-3806	2913	30	and	and	CCONJ
fnp-3806	2913	31	causes	cause	VERB
fnp-3806	2913	32	neuronal	neuronal	ADJ
fnp-3806	2913	33	apoptosis	apoptosis	NOUN
fnp-3806	2913	34	by	by	ADP
fnp-3806	2913	35	inducing	induce	VERB
fnp-3806	2913	36	p75	p75	ADJ
fnp-3806	2913	37	neutrophin	neutrophin	ADJ
fnp-3806	2913	38	receptor	receptor	NOUN
fnp-3806	2913	39	processing	processing	NOUN
fnp-3806	2913	40	.	.	PUNCT
fnp-3806	2914	1	mol	mol	ADP
fnp-3806	2914	2	brain	brain	PROPN
fnp-3806	2914	3	2018;11:68	2018;11:68	NUM
fnp-3806	2914	4	.	.	PUNCT
fnp-3806	2915	1	https://doi.org/10.1186/s13041-018-0411-6	https://doi.org/10.1186/s13041-018-0411-6	NUM
fnp-3806	2916	1	ye	ye	NUM
fnp-3806	2916	2	x	x	NOUN
fnp-3806	2916	3	,	,	PUNCT
fnp-3806	2916	4	tai	tai	PROPN
fnp-3806	2916	5	w	w	PROPN
fnp-3806	2916	6	,	,	PUNCT
fnp-3806	2916	7	zhang	zhang	PROPN
fnp-3806	2916	8	d.	d.	PROPN
fnp-3806	2916	9	the	the	DET
fnp-3806	2916	10	early	early	ADJ
fnp-3806	2916	11	events	event	NOUN
fnp-3806	2916	12	of	of	ADP
fnp-3806	2916	13	alzheimer	alzheimer	PROPN
fnp-3806	2916	14	's	's	PART
fnp-3806	2916	15	disease	disease	NOUN
fnp-3806	2916	16	pathology	pathology	NOUN
fnp-3806	2916	17	:	:	PUNCT
fnp-3806	2916	18	from	from	ADP
fnp-3806	2916	19	mitochondrial	mitochondrial	ADJ
fnp-3806	2916	20	dysfunction	dysfunction	NOUN
fnp-3806	2916	21	to	to	PART
fnp-3806	2916	22	bdnf	bdnf	VERB
fnp-3806	2916	23	axonal	axonal	ADJ
fnp-3806	2916	24	transport	transport	NOUN
fnp-3806	2916	25	deficits	deficit	NOUN
fnp-3806	2916	26	.	.	PUNCT
fnp-3806	2917	1	neurobiol	neurobiol	ADJ
fnp-3806	2917	2	aging	age	VERB
fnp-3806	2917	3	2012;33:1122.e1	2012;33:1122.e1	PROPN
fnp-3806	2917	4	-	-	PUNCT
fnp-3806	2917	5	10	10	NUM
fnp-3806	2917	6	.	.	PUNCT
fnp-3806	2918	1	https://doi.org/10.1016/j.neurobiolaging.2011.11.004	https://doi.org/10.1016/j.neurobiolaging.2011.11.004	NUM
fnp-3806	2918	2	hellweg	hellweg	ADJ
fnp-3806	2918	3	r	r	NOUN
fnp-3806	2918	4	,	,	PUNCT
fnp-3806	2918	5	gericke	gericke	PROPN
fnp-3806	2918	6	ca	can	AUX
fnp-3806	2918	7	,	,	PUNCT
fnp-3806	2918	8	jendroska	jendroska	PROPN
fnp-3806	2918	9	k	k	PROPN
fnp-3806	2918	10	,	,	PUNCT
fnp-3806	2918	11	et	et	PROPN
fnp-3806	2918	12	al	al	PROPN
fnp-3806	2918	13	.	.	PUNCT
fnp-3806	2919	1	ngf	ngf	PROPN
fnp-3806	2919	2	content	content	NOUN
fnp-3806	2919	3	in	in	ADP
fnp-3806	2919	4	the	the	DET
fnp-3806	2919	5	cerebral	cerebral	ADJ
fnp-3806	2919	6	cortex	cortex	NOUN
fnp-3806	2919	7	of	of	ADP
fnp-3806	2919	8	non	non	ADJ
fnp-3806	2919	9	-	-	ADJ
fnp-3806	2919	10	demented	demented	ADJ
fnp-3806	2919	11	patients	patient	NOUN
fnp-3806	2919	12	with	with	ADP
fnp-3806	2919	13	amyloid	amyloid	NOUN
fnp-3806	2919	14	-	-	PUNCT
fnp-3806	2919	15	plaques	plaque	NOUN
fnp-3806	2919	16	and	and	CCONJ
fnp-3806	2919	17	in	in	ADP
fnp-3806	2919	18	symptomatic	symptomatic	ADJ
fnp-3806	2919	19	alzheimer	alzheimer	PROPN
fnp-3806	2919	20	’s	’s	PART
fnp-3806	2919	21	disease	disease	NOUN
fnp-3806	2919	22	.	.	PUNCT
fnp-3806	2920	1	int	int	PROPN
fnp-3806	2921	1	j	j	PROPN
fnp-3806	2921	2	dev	dev	PROPN
fnp-3806	2921	3	neurosci	neurosci	PROPN
fnp-3806	2921	4	1998	1998	NUM
fnp-3806	2921	5	;	;	PUNCT
fnp-3806	2921	6	16:787	16:787	NUM
fnp-3806	2921	7	-	-	SYM
fnp-3806	2921	8	794	794	NUM
fnp-3806	2921	9	.	.	PUNCT
fnp-3806	2922	1	https://doi.org/10.1016/s0736-5748(98)00088-4	https://doi.org/10.1016/s0736-5748(98)00088-4	VERB
fnp-3806	2922	2	mufson	mufson	PROPN
fnp-3806	2922	3	ej	ej	PROPN
fnp-3806	2922	4	,	,	PUNCT
fnp-3806	2922	5	kordower	kordower	PROPN
fnp-3806	2922	6	jh	jh	PROPN
fnp-3806	2922	7	.	.	PUNCT
fnp-3806	2923	1	nerve	nerve	NOUN
fnp-3806	2923	2	growth	growth	NOUN
fnp-3806	2923	3	factor	factor	NOUN
fnp-3806	2923	4	receptor	receptor	NOUN
fnp-3806	2923	5	expressing	express	VERB
fnp-3806	2923	6	human	human	ADJ
fnp-3806	2923	7	basal	basal	ADJ
fnp-3806	2923	8	forebrain	forebrain	NOUN
fnp-3806	2923	9	neurons	neuron	NOUN
fnp-3806	2923	10	:	:	PUNCT
fnp-3806	2923	11	pathologic	pathologic	ADJ
fnp-3806	2923	12	alterations	alteration	NOUN
fnp-3806	2923	13	in	in	ADP
fnp-3806	2923	14	alzheimer	alzheimer	PROPN
fnp-3806	2923	15	's	's	PART
fnp-3806	2923	16	and	and	CCONJ
fnp-3806	2923	17	parkinson	parkinson	NOUN
fnp-3806	2923	18	's	's	PART
fnp-3806	2923	19	disease	disease	NOUN
fnp-3806	2923	20	.	.	PUNCT
fnp-3806	2924	1	prog	prog	PROPN
fnp-3806	2924	2	clin	clin	PROPN
fnp-3806	2924	3	biol	biol	PROPN
fnp-3806	2924	4	res	re	VERB
fnp-3806	2924	5	1989;317:401	1989;317:401	NUM
fnp-3806	2924	6	-	-	SYM
fnp-3806	2924	7	414	414	NUM
fnp-3806	2924	8	.	.	PUNCT
fnp-3806	2925	1	pmid	pmid	NOUN
fnp-3806	2925	2	:	:	PUNCT
fnp-3806	2925	3	2557638	2557638	NUM
fnp-3806	2925	4	.	.	PUNCT
fnp-3806	2926	1	fahnestock	fahnestock	PROPN
fnp-3806	2926	2	m	m	PROPN
fnp-3806	2926	3	,	,	PUNCT
fnp-3806	2926	4	michalski	michalski	PROPN
fnp-3806	2926	5	b	b	PROPN
fnp-3806	2926	6	,	,	PUNCT
fnp-3806	2926	7	xu	xu	PROPN
fnp-3806	2927	1	b	b	PROPN
fnp-3806	2927	2	,	,	PUNCT
fnp-3806	2927	3	et	et	PROPN
fnp-3806	2927	4	al	al	PROPN
fnp-3806	2927	5	.	.	PUNCT
fnp-3806	2928	1	the	the	DET
fnp-3806	2928	2	precursor	precursor	NOUN
fnp-3806	2928	3	pro	pro	ADJ
fnp-3806	2928	4	-	-	ADJ
fnp-3806	2928	5	nerve	nerve	ADJ
fnp-3806	2928	6	growth	growth	NOUN
fnp-3806	2928	7	factor	factor	NOUN
fnp-3806	2928	8	is	be	AUX
fnp-3806	2928	9	the	the	DET
fnp-3806	2928	10	predominant	predominant	ADJ
fnp-3806	2928	11	form	form	NOUN
fnp-3806	2928	12	of	of	ADP
fnp-3806	2928	13	nerve	nerve	NOUN
fnp-3806	2928	14	growth	growth	NOUN
fnp-3806	2928	15	factor	factor	NOUN
fnp-3806	2928	16	in	in	ADP
fnp-3806	2928	17	brain	brain	NOUN
fnp-3806	2928	18	and	and	CCONJ
fnp-3806	2928	19	is	be	AUX
fnp-3806	2928	20	increased	increase	VERB
fnp-3806	2928	21	in	in	ADP
fnp-3806	2928	22	alzheimer	alzheimer	PROPN
fnp-3806	2928	23	’s	’s	PART
fnp-3806	2928	24	disease	disease	NOUN
fnp-3806	2928	25	.	.	PUNCT
fnp-3806	2929	1	mol	mol	ADP
fnp-3806	2929	2	cell	cell	NOUN
fnp-3806	2929	3	neurosci	neurosci	NOUN
fnp-3806	2929	4	2001	2001	NUM
fnp-3806	2929	5	;	;	PUNCT
fnp-3806	2929	6	18:210	18:210	NUM
fnp-3806	2929	7	-	-	SYM
fnp-3806	2929	8	220	220	NUM
fnp-3806	2929	9	.	.	PUNCT
fnp-3806	2930	1	https://doi.org/10.1006/mcne.2001.1016	https://doi.org/10.1006/mcne.2001.1016	PROPN
fnp-3806	2930	2	peng	peng	PROPN
fnp-3806	2930	3	s	s	PROPN
fnp-3806	2930	4	,	,	PUNCT
fnp-3806	2930	5	wuu	wuu	PROPN
fnp-3806	2930	6	j	j	PROPN
fnp-3806	2930	7	,	,	PUNCT
fnp-3806	2930	8	mufson	mufson	NOUN
fnp-3806	2930	9	ej	ej	PROPN
fnp-3806	2930	10	,	,	PUNCT
fnp-3806	2930	11	et	et	PROPN
fnp-3806	2930	12	al	al	PROPN
fnp-3806	2930	13	.	.	PROPN
fnp-3806	2930	14	increased	increase	VERB
fnp-3806	2930	15	prongf	prongf	NOUN
fnp-3806	2930	16	levels	level	NOUN
fnp-3806	2930	17	in	in	ADP
fnp-3806	2930	18	subjects	subject	NOUN
fnp-3806	2930	19	with	with	ADP
fnp-3806	2930	20	mild	mild	ADJ
fnp-3806	2930	21	cognitive	cognitive	ADJ
fnp-3806	2930	22	impairment	impairment	NOUN
fnp-3806	2930	23	and	and	CCONJ
fnp-3806	2930	24	mild	mild	ADJ
fnp-3806	2930	25	alzheimer	alzheimer	NOUN
fnp-3806	2930	26	disease	disease	NOUN
fnp-3806	2930	27	.	.	PUNCT
fnp-3806	2931	1	j	j	PROPN
fnp-3806	2931	2	neuropathol	neuropathol	PROPN
fnp-3806	2931	3	exp	exp	PROPN
fnp-3806	2931	4	neurol	neurol	PROPN
fnp-3806	2931	5	2004	2004	NUM
fnp-3806	2931	6	;	;	PUNCT
fnp-3806	2931	7	63:641	63:641	NUM
fnp-3806	2931	8	-	-	SYM
fnp-3806	2931	9	649	649	NUM
fnp-3806	2931	10	.	.	PUNCT
fnp-3806	2932	1	https://doi.org/10.1093/jnen/63.6.641	https://doi.org/10.1093/jnen/63.6.641	PROPN
fnp-3806	2932	2	pedraza	pedraza	PROPN
fnp-3806	2932	3	ce	ce	PROPN
fnp-3806	2932	4	,	,	PUNCT
fnp-3806	2932	5	podlesniy	podlesniy	NOUN
fnp-3806	2932	6	p	p	NOUN
fnp-3806	2932	7	,	,	PUNCT
fnp-3806	2932	8	vidal	vidal	NOUN
fnp-3806	2932	9	n	n	CCONJ
fnp-3806	2932	10	,	,	PUNCT
fnp-3806	2932	11	et	et	PROPN
fnp-3806	2932	12	al	al	PROPN
fnp-3806	2932	13	.	.	PUNCT
fnp-3806	2933	1	pro	pro	ADJ
fnp-3806	2933	2	-	-	ADJ
fnp-3806	2933	3	ngf	ngf	ADV
fnp-3806	2933	4	isolated	isolate	VERB
fnp-3806	2933	5	from	from	ADP
fnp-3806	2933	6	the	the	DET
fnp-3806	2933	7	human	human	ADJ
fnp-3806	2933	8	brain	brain	NOUN
fnp-3806	2933	9	affected	affect	VERB
fnp-3806	2933	10	by	by	ADP
fnp-3806	2933	11	alzheimer	alzheimer	PROPN
fnp-3806	2933	12	’s	’s	PART
fnp-3806	2933	13	disease	disease	NOUN
fnp-3806	2933	14	induces	induce	VERB
fnp-3806	2933	15	neuronal	neuronal	ADJ
fnp-3806	2933	16	apoptosis	apoptosis	NOUN
fnp-3806	2933	17	mediated	mediate	VERB
fnp-3806	2933	18	by	by	ADP
fnp-3806	2933	19	p75ntr	p75ntr	PROPN
fnp-3806	2933	20	.	.	PUNCT
fnp-3806	2934	1	am	be	AUX
fnp-3806	2934	2	j	j	NOUN
fnp-3806	2934	3	pathol	pathol	NOUN
fnp-3806	2934	4	2005	2005	NUM
fnp-3806	2934	5	;	;	PUNCT
fnp-3806	2934	6	166:533	166:533	PROPN
fnp-3806	2934	7	-	-	SYM
fnp-3806	2934	8	543	543	NUM
fnp-3806	2934	9	.	.	PUNCT
fnp-3806	2935	1	https://doi.org/10.1016/s0002-9440(10)62275-4	https://doi.org/10.1016/s0002-9440(10)62275-4	NOUN
fnp-3806	2935	2	podlesniy	podlesniy	PROPN
fnp-3806	2935	3	p	p	NOUN
fnp-3806	2935	4	,	,	PUNCT
fnp-3806	2935	5	kichev	kichev	NOUN
fnp-3806	2935	6	a	a	NOUN
fnp-3806	2935	7	,	,	PUNCT
fnp-3806	2935	8	pedraza	pedraza	PROPN
fnp-3806	2935	9	c	c	X
fnp-3806	2935	10	,	,	PUNCT
fnp-3806	2935	11	et	et	PROPN
fnp-3806	2935	12	al	al	PROPN
fnp-3806	2935	13	.	.	PUNCT
fnp-3806	2936	1	pro	pro	ADJ
fnp-3806	2936	2	-	-	ADJ
fnp-3806	2936	3	ngf	ngf	ADV
fnp-3806	2936	4	from	from	ADP
fnp-3806	2936	5	alzheimer	alzheimer	PROPN
fnp-3806	2936	6	’s	’s	PART
fnp-3806	2936	7	disease	disease	NOUN
fnp-3806	2936	8	and	and	CCONJ
fnp-3806	2936	9	normal	normal	ADJ
fnp-3806	2936	10	human	human	ADJ
fnp-3806	2936	11	brain	brain	NOUN
fnp-3806	2936	12	displays	display	VERB
fnp-3806	2936	13	distinctive	distinctive	ADJ
fnp-3806	2936	14	abilities	ability	NOUN
fnp-3806	2936	15	to	to	PART
fnp-3806	2936	16	induce	induce	VERB
fnp-3806	2936	17	processing	processing	NOUN
fnp-3806	2936	18	and	and	CCONJ
fnp-3806	2936	19	nuclear	nuclear	ADJ
fnp-3806	2936	20	translocation	translocation	NOUN
fnp-3806	2936	21	of	of	ADP
fnp-3806	2936	22	intracellular	intracellular	ADJ
fnp-3806	2936	23	domain	domain	NOUN
fnp-3806	2936	24	of	of	ADP
fnp-3806	2936	25	p75ntr	p75ntr	NOUN
fnp-3806	2936	26	and	and	CCONJ
fnp-3806	2936	27	apoptosis	apoptosis	NOUN
fnp-3806	2936	28	.	.	PUNCT
fnp-3806	2937	1	am	be	AUX
fnp-3806	2937	2	j	j	PROPN
fnp-3806	2937	3	pathol	pathol	NOUN
fnp-3806	2937	4	2006	2006	NUM
fnp-3806	2937	5	;	;	PUNCT
fnp-3806	2937	6	169:119	169:119	PROPN
fnp-3806	2937	7	-	-	SYM
fnp-3806	2937	8	131	131	NUM
fnp-3806	2937	9	.	.	PUNCT
fnp-3806	2938	1	https://doi.org/10.2353/ajpath.2006.050787	https://doi.org/10.2353/ajpath.2006.050787	PROPN
fnp-3806	2938	2	al	al	PROPN
fnp-3806	2938	3	-	-	PUNCT
fnp-3806	2938	4	shawi	shawi	NOUN
fnp-3806	2938	5	r	r	NOUN
fnp-3806	2938	6	,	,	PUNCT
fnp-3806	2938	7	hafner	hafner	PROPN
fnp-3806	2938	8	a	a	PRON
fnp-3806	2938	9	,	,	PUNCT
fnp-3806	2938	10	olsen	olsen	PROPN
fnp-3806	2938	11	j	j	PROPN
fnp-3806	2938	12	,	,	PUNCT
fnp-3806	2938	13	et	et	PROPN
fnp-3806	2938	14	al	al	PROPN
fnp-3806	2938	15	.	.	PROPN
fnp-3806	2938	16	neurotoxic	neurotoxic	ADJ
fnp-3806	2938	17	and	and	CCONJ
fnp-3806	2938	18	neurotrophic	neurotrophic	ADJ
fnp-3806	2938	19	roles	role	NOUN
fnp-3806	2938	20	of	of	ADP
fnp-3806	2938	21	prongf	prongf	NOUN
fnp-3806	2938	22	and	and	CCONJ
fnp-3806	2938	23	the	the	DET
fnp-3806	2938	24	receptor	receptor	NOUN
fnp-3806	2938	25	sortilin	sortilin	NOUN
fnp-3806	2938	26	in	in	ADP
fnp-3806	2938	27	the	the	DET
fnp-3806	2938	28	adult	adult	NOUN
fnp-3806	2938	29	and	and	CCONJ
fnp-3806	2938	30	ageing	age	VERB
fnp-3806	2938	31	nervous	nervous	ADJ
fnp-3806	2938	32	system	system	NOUN
fnp-3806	2938	33	.	.	PUNCT
fnp-3806	2939	1	eur	eur	PROPN
fnp-3806	2939	2	j	j	PROPN
fnp-3806	2939	3	neurosci	neurosci	PROPN
fnp-3806	2939	4	2008	2008	NUM
fnp-3806	2939	5	;	;	PUNCT
fnp-3806	2939	6	27:2103	27:2103	NOUN
fnp-3806	2939	7	-	-	SYM
fnp-3806	2939	8	2114	2114	NUM
fnp-3806	2939	9	.	.	PUNCT
fnp-3806	2940	1	https://doi.org/10.1111/j.1460-9568.2008.06152.x	https://doi.org/10.1111/j.1460-9568.2008.06152.x	PROPN
fnp-3806	2940	2	lin	lin	PROPN
fnp-3806	2940	3	jh	jh	PROPN
fnp-3806	2940	4	,	,	PUNCT
fnp-3806	2940	5	walter	walter	PROPN
fnp-3806	2940	6	p	p	PROPN
fnp-3806	2940	7	,	,	PUNCT
fnp-3806	2940	8	yen	yen	NOUN
fnp-3806	2940	9	tsb	tsb	NOUN
fnp-3806	2940	10	.	.	PUNCT
fnp-3806	2941	1	endoplasmic	endoplasmic	ADJ
fnp-3806	2941	2	reticulum	reticulum	NOUN
fnp-3806	2941	3	stress	stress	NOUN
fnp-3806	2941	4	in	in	ADP
fnp-3806	2941	5	disease	disease	NOUN
fnp-3806	2941	6	pathogenesis	pathogenesis	NOUN
fnp-3806	2941	7	.	.	PUNCT
fnp-3806	2942	1	annu	annu	PROPN
fnp-3806	2942	2	rev	rev	PROPN
fnp-3806	2942	3	pathol	pathol	PROPN
fnp-3806	2942	4	2008;3:399	2008;3:399	NUM
fnp-3806	2942	5	-	-	SYM
fnp-3806	2942	6	425	425	NUM
fnp-3806	2942	7	.	.	PUNCT
fnp-3806	2943	1	https://doi.org/10.1146/annurev.pathmechdis.3.121806.151434	https://doi.org/10.1146/annurev.pathmechdis.3.121806.151434	NOUN
fnp-3806	2943	2	kozutsumi	kozutsumi	PROPN
fnp-3806	2943	3	y	y	PROPN
fnp-3806	2943	4	,	,	PUNCT
fnp-3806	2943	5	segal	segal	PROPN
fnp-3806	2943	6	m	m	PROPN
fnp-3806	2943	7	,	,	PUNCT
fnp-3806	2943	8	normington	normington	PROPN
fnp-3806	2943	9	k	k	PROPN
fnp-3806	2943	10	,	,	PUNCT
fnp-3806	2943	11	et	et	PROPN
fnp-3806	2943	12	al	al	PROPN
fnp-3806	2943	13	.	.	PUNCT
fnp-3806	2944	1	the	the	DET
fnp-3806	2944	2	presence	presence	NOUN
fnp-3806	2944	3	of	of	ADP
fnp-3806	2944	4	malfolded	malfolded	ADJ
fnp-3806	2944	5	proteins	protein	NOUN
fnp-3806	2944	6	in	in	ADP
fnp-3806	2944	7	the	the	DET
fnp-3806	2944	8	endoplasmic	endoplasmic	ADJ
fnp-3806	2944	9	reticulum	reticulum	NOUN
fnp-3806	2944	10	signals	signal	VERB
fnp-3806	2944	11	the	the	DET
fnp-3806	2944	12	induction	induction	NOUN
fnp-3806	2944	13	of	of	ADP
fnp-3806	2944	14	glucose	glucose	NOUN
fnp-3806	2944	15	-	-	PUNCT
fnp-3806	2944	16	regulated	regulate	VERB
fnp-3806	2944	17	proteins	protein	NOUN
fnp-3806	2944	18	.	.	PUNCT
fnp-3806	2945	1	nature	nature	NOUN
fnp-3806	2945	2	1998;332:462	1998;332:462	PROPN
fnp-3806	2945	3	-	-	SYM
fnp-3806	2945	4	464	464	NUM
fnp-3806	2945	5	.	.	PUNCT
fnp-3806	2946	1	https://doi.org/10.1038/332462a0	https://doi.org/10.1038/332462a0	PROPN
fnp-3806	2946	2	oakes	oakes	PROPN
fnp-3806	2946	3	sa	sa	PROPN
fnp-3806	2946	4	,	,	PUNCT
fnp-3806	2946	5	papa	papa	VERB
fnp-3806	2946	6	fr	fr	NOUN
fnp-3806	2946	7	.	.	PUNCT
fnp-3806	2947	1	the	the	DET
fnp-3806	2947	2	role	role	NOUN
fnp-3806	2947	3	of	of	ADP
fnp-3806	2947	4	endoplasmic	endoplasmic	ADJ
fnp-3806	2947	5	reticulum	reticulum	NOUN
fnp-3806	2947	6	stress	stress	NOUN
fnp-3806	2947	7	in	in	ADP
fnp-3806	2947	8	human	human	ADJ
fnp-3806	2947	9	pathology	pathology	NOUN
fnp-3806	2947	10	.	.	PUNCT
fnp-3806	2948	1	annu	annu	PROPN
fnp-3806	2948	2	rev	rev	PROPN
fnp-3806	2948	3	pathol	pathol	NOUN
fnp-3806	2948	4	.	.	PUNCT
fnp-3806	2949	1	2015;10:173	2015;10:173	NUM
fnp-3806	2949	2	-	-	SYM
fnp-3806	2949	3	194	194	NUM
fnp-3806	2949	4	.	.	PUNCT
fnp-3806	2950	1	https://doi.org/10.1146/annurev-pathol-012513-104649	https://doi.org/10.1146/annurev-pathol-012513-104649	PROPN
fnp-3806	2950	2	hoozemans	hoozemans	PROPN
fnp-3806	2950	3	jjm	jjm	PROPN
fnp-3806	2950	4	,	,	PUNCT
fnp-3806	2950	5	veerhuis	veerhuis	NOUN
fnp-3806	2950	6	r	r	PROPN
fnp-3806	2950	7	,	,	PUNCT
fnp-3806	2950	8	van	van	PROPN
fnp-3806	2950	9	haastert	haastert	PROPN
fnp-3806	2950	10	es	es	PROPN
fnp-3806	2950	11	,	,	PUNCT
fnp-3806	2950	12	et	et	PROPN
fnp-3806	2950	13	al	al	PROPN
fnp-3806	2950	14	.	.	PUNCT
fnp-3806	2951	1	the	the	DET
fnp-3806	2951	2	unfolded	unfold	VERB
fnp-3806	2951	3	protein	protein	NOUN
fnp-3806	2951	4	response	response	NOUN
fnp-3806	2951	5	is	be	AUX
fnp-3806	2951	6	activated	activate	VERB
fnp-3806	2951	7	in	in	ADP
fnp-3806	2951	8	alzheimer	alzheimer	PROPN
fnp-3806	2951	9	’s	’s	PART
fnp-3806	2951	10	disease	disease	NOUN
fnp-3806	2951	11	.	.	PUNCT
fnp-3806	2952	1	acta	acta	PROPN
fnp-3806	2952	2	neuropathol	neuropathol	PROPN
fnp-3806	2952	3	2005	2005	NUM
fnp-3806	2952	4	;	;	PUNCT
fnp-3806	2953	1	110:165	110:165	NUM
fnp-3806	2953	2	-	-	SYM
fnp-3806	2953	3	172	172	NUM
fnp-3806	2953	4	.	.	PUNCT
fnp-3806	2954	1	https://doi.org/10.1007/s00401-005-1038-0	https://doi.org/10.1007/s00401-005-1038-0	PROPN
fnp-3806	2954	2	hoozemans	hoozemans	PROPN
fnp-3806	2954	3	jj	jj	PROPN
fnp-3806	2954	4	,	,	PUNCT
fnp-3806	2954	5	van	van	PROPN
fnp-3806	2954	6	haastert	haastert	PROPN
fnp-3806	2954	7	es	es	PROPN
fnp-3806	2954	8	,	,	PUNCT
fnp-3806	2954	9	nijholt	nijholt	NOUN
fnp-3806	2954	10	da	da	PROPN
fnp-3806	2954	11	,	,	PUNCT
fnp-3806	2954	12	et	et	PROPN
fnp-3806	2954	13	al	al	PROPN
fnp-3806	2954	14	.	.	PUNCT
fnp-3806	2955	1	the	the	DET
fnp-3806	2955	2	unfolded	unfold	VERB
fnp-3806	2955	3	protein	protein	NOUN
fnp-3806	2955	4	response	response	NOUN
fnp-3806	2955	5	is	be	AUX
fnp-3806	2955	6	activated	activate	VERB
fnp-3806	2955	7	in	in	ADP
fnp-3806	2955	8	pretangle	pretangle	NOUN
fnp-3806	2955	9	neurons	neuron	NOUN
fnp-3806	2955	10	in	in	ADP
fnp-3806	2955	11	alzheimer	alzheimer	PROPN
fnp-3806	2955	12	’s	’s	PART
fnp-3806	2955	13	disease	disease	NOUN
fnp-3806	2955	14	hippocampus	hippocampus	NOUN
fnp-3806	2955	15	.	.	PUNCT
fnp-3806	2956	1	am	be	AUX
fnp-3806	2956	2	j	j	PROPN
fnp-3806	2956	3	pathol	pathol	NOUN
fnp-3806	2956	4	2009;174:1241	2009;174:1241	NUM
fnp-3806	2956	5	-	-	SYM
fnp-3806	2956	6	1251	1251	NUM
fnp-3806	2956	7	.	.	PUNCT
fnp-3806	2957	1	https://doi.org/10.2353/ajpath.2009.080814	https://doi.org/10.2353/ajpath.2009.080814	PROPN
fnp-3806	2957	2	huang	huang	PROPN
fnp-3806	2957	3	hc	hc	PROPN
fnp-3806	2957	4	,	,	PUNCT
fnp-3806	2957	5	tang	tang	X
fnp-3806	2957	6	d	d	NOUN
fnp-3806	2957	7	,	,	PUNCT
fnp-3806	2957	8	lu	lu	PROPN
fnp-3806	2957	9	sy	sy	PROPN
fnp-3806	2957	10	,	,	PUNCT
fnp-3806	2957	11	et	et	PROPN
fnp-3806	2957	12	al	al	PROPN
fnp-3806	2957	13	.	.	PUNCT
fnp-3806	2958	1	endoplasmic	endoplasmic	ADJ
fnp-3806	2958	2	reticulum	reticulum	NOUN
fnp-3806	2958	3	stress	stress	NOUN
fnp-3806	2958	4	as	as	ADP
fnp-3806	2958	5	a	a	DET
fnp-3806	2958	6	novel	novel	ADJ
fnp-3806	2958	7	neuronal	neuronal	ADJ
fnp-3806	2958	8	mediator	mediator	NOUN
fnp-3806	2958	9	in	in	ADP
fnp-3806	2958	10	alzheimer	alzheimer	PROPN
fnp-3806	2958	11	's	's	PART
fnp-3806	2958	12	disease	disease	NOUN
fnp-3806	2958	13	.	.	PUNCT
fnp-3806	2959	1	neurol	neurol	NOUN
fnp-3806	2959	2	res	re	NOUN
fnp-3806	2959	3	2015;37:366	2015;37:366	PROPN
fnp-3806	2959	4	-	-	SYM
fnp-3806	2959	5	374	374	NUM
fnp-3806	2959	6	.	.	PUNCT
fnp-3806	2960	1	https://doi.org/10.1179/1743132814y.0000000448	https://doi.org/10.1179/1743132814y.0000000448	PROPN
fnp-3806	2960	2	li	li	PROPN
fnp-3806	2960	3	jq	jq	PROPN
fnp-3806	2960	4	,	,	PUNCT
fnp-3806	2960	5	yu	yu	PROPN
fnp-3806	2960	6	jt	jt	PROPN
fnp-3806	2960	7	,	,	PUNCT
fnp-3806	2960	8	jiang	jiang	PROPN
fnp-3806	2960	9	t	t	PROPN
fnp-3806	2960	10	,	,	PUNCT
fnp-3806	2960	11	tan	tan	PROPN
fnp-3806	2960	12	l.	l.	PROPN
fnp-3806	2960	13	endoplasmic	endoplasmic	ADJ
fnp-3806	2960	14	reticulum	reticulum	NOUN
fnp-3806	2960	15	dysfunction	dysfunction	NOUN
fnp-3806	2960	16	in	in	ADP
fnp-3806	2960	17	alzheimer	alzheimer	PROPN
fnp-3806	2960	18	’s	’s	PART
fnp-3806	2960	19	disease	disease	NOUN
fnp-3806	2960	20	.	.	PUNCT
fnp-3806	2961	1	mol	mol	ADP
fnp-3806	2961	2	neurobiol	neurobiol	PROPN
fnp-3806	2961	3	2015;51:383	2015;51:383	PROPN
fnp-3806	2961	4	-	-	SYM
fnp-3806	2961	5	395	395	NUM
fnp-3806	2961	6	.	.	PUNCT
fnp-3806	2962	1	https://doi.org/10.1007/s12035-014-8695-8	https://doi.org/10.1007/s12035-014-8695-8	PROPN
fnp-3806	2962	2	takuma	takuma	PROPN
fnp-3806	2962	3	k	k	PROPN
fnp-3806	2962	4	,	,	PUNCT
fnp-3806	2962	5	yan	yan	PROPN
fnp-3806	2962	6	ss	ss	PROPN
fnp-3806	2962	7	,	,	PUNCT
fnp-3806	2962	8	stern	stern	PROPN
fnp-3806	2962	9	dm	dm	PROPN
fnp-3806	2962	10	,	,	PUNCT
fnp-3806	2962	11	et	et	PROPN
fnp-3806	2962	12	al	al	PROPN
fnp-3806	2962	13	.	.	PROPN
fnp-3806	2962	14	mitocondrial	mitocondrial	ADJ
fnp-3806	2962	15	dysfunction	dysfunction	NOUN
fnp-3806	2962	16	,	,	PUNCT
fnp-3806	2962	17	endoplasmic	endoplasmic	ADJ
fnp-3806	2962	18	reticulum	reticulum	NOUN
fnp-3806	2962	19	stress	stress	NOUN
fnp-3806	2962	20	,	,	PUNCT
fnp-3806	2962	21	and	and	CCONJ
fnp-3806	2962	22	apoptosis	apoptosis	NOUN
fnp-3806	2962	23	in	in	ADP
fnp-3806	2962	24	alzheimer	alzheimer	PROPN
fnp-3806	2962	25	’s	’s	PART
fnp-3806	2962	26	disease	disease	NOUN
fnp-3806	2962	27	.	.	PUNCT
fnp-3806	2963	1	j	j	PROPN
fnp-3806	2963	2	pharmacol	pharmacol	PROPN
fnp-3806	2963	3	sci	sci	PROPN
fnp-3806	2963	4	2005;97:312	2005;97:312	PROPN
fnp-3806	2963	5	-	-	PUNCT
fnp-3806	2963	6	316	316	NUM
fnp-3806	2963	7	.	.	PUNCT
fnp-3806	2964	1	https://doi.org/10.1254/jphs	https://doi.org/10.1254/jph	NOUN
fnp-3806	2964	2	cpj04006x	cpj04006x	NOUN
fnp-3806	2964	3	.	.	PUNCT
fnp-3806	2965	1	santos	santos	PROPN
fnp-3806	2965	2	le	le	PROPN
fnp-3806	2965	3	,	,	PUNCT
fnp-3806	2965	4	ferreira	ferreira	PROPN
fnp-3806	2965	5	st	st	PROPN
fnp-3806	2965	6	.	.	PROPN
fnp-3806	2965	7	crosstalk	crosstalk	PROPN
fnp-3806	2965	8	between	between	ADP
fnp-3806	2965	9	endoplasmic	endoplasmic	ADJ
fnp-3806	2965	10	reticulum	reticulum	NOUN
fnp-3806	2965	11	stress	stress	NOUN
fnp-3806	2965	12	and	and	CCONJ
fnp-3806	2965	13	brain	brain	NOUN
fnp-3806	2965	14	inflammation	inflammation	NOUN
fnp-3806	2965	15	in	in	ADP
fnp-3806	2965	16	alzheimer	alzheimer	PROPN
fnp-3806	2965	17	's	's	PART
fnp-3806	2965	18	disease	disease	NOUN
fnp-3806	2965	19	.	.	PUNCT
fnp-3806	2966	1	neuropharmacology	neuropharmacology	NOUN
fnp-3806	2966	2	2018;136:350	2018;136:350	PROPN
fnp-3806	2966	3	-	-	SYM
fnp-3806	2966	4	360	360	NUM
fnp-3806	2966	5	.	.	PUNCT
fnp-3806	2967	1	https://doi.org/10.1016/j.neuropharm.2017.11.016	https://doi.org/10.1016/j.neuropharm.2017.11.016	PROPN
fnp-3806	2967	2	salminen	salminen	NOUN
fnp-3806	2967	3	a	a	PRON
fnp-3806	2967	4	,	,	PUNCT
fnp-3806	2967	5	kaarniranta	kaarniranta	PROPN
fnp-3806	2967	6	k	k	PROPN
fnp-3806	2967	7	,	,	PUNCT
fnp-3806	2967	8	kauppinen	kauppinen	PROPN
fnp-3806	2967	9	a.	a.	NOUN
fnp-3806	2967	10	er	er	PROPN
fnp-3806	2967	11	stress	stress	NOUN
fnp-3806	2967	12	activates	activate	VERB
fnp-3806	2967	13	immunosuppressive	immunosuppressive	ADJ
fnp-3806	2967	14	network	network	NOUN
fnp-3806	2967	15	:	:	PUNCT
fnp-3806	2967	16	implications	implication	NOUN
fnp-3806	2967	17	for	for	ADP
fnp-3806	2967	18	aging	aging	NOUN
fnp-3806	2967	19	and	and	CCONJ
fnp-3806	2967	20	alzheimer	alzheimer	NOUN
fnp-3806	2967	21	's	's	PART
fnp-3806	2967	22	disease	disease	NOUN
fnp-3806	2967	23	.	.	PUNCT
fnp-3806	2968	1	j	j	PROPN
fnp-3806	2968	2	mol	mol	ADP
fnp-3806	2968	3	med	med	PROPN
fnp-3806	2968	4	2020;98:633	2020;98:633	PROPN
fnp-3806	2968	5	-	-	SYM
fnp-3806	2968	6	650	650	NUM
fnp-3806	2968	7	.	.	PUNCT
fnp-3806	2969	1	https://doi.org/10.1007/s00109-020-01904-z	https://doi.org/10.1007/s00109-020-01904-z	PROPN
fnp-3806	2969	2	liu	liu	PROPN
fnp-3806	2969	3	xj	xj	PROPN
fnp-3806	2969	4	,	,	PUNCT
fnp-3806	2969	5	wei	wei	PROPN
fnp-3806	2969	6	j	j	PROPN
fnp-3806	2969	7	,	,	PUNCT
fnp-3806	2969	8	shang	shang	PROPN
fnp-3806	2969	9	yh	yh	PROPN
fnp-3806	2969	10	,	,	PUNCT
fnp-3806	2969	11	et	et	PROPN
fnp-3806	2969	12	al	al	PROPN
fnp-3806	2969	13	.	.	PROPN
fnp-3806	2969	14	modulation	modulation	NOUN
fnp-3806	2969	15	of	of	ADP
fnp-3806	2969	16	aβpp	aβpp	NOUN
fnp-3806	2969	17	and	and	CCONJ
fnp-3806	2969	18	gsk3β	gsk3β	PROPN
fnp-3806	2969	19	by	by	ADP
fnp-3806	2969	20	endoplasmic	endoplasmic	ADJ
fnp-3806	2969	21	reticulum	reticulum	NOUN
fnp-3806	2969	22	stress	stress	NOUN
fnp-3806	2969	23	and	and	CCONJ
fnp-3806	2969	24	involvement	involvement	NOUN
fnp-3806	2969	25	in	in	ADP
fnp-3806	2969	26	alzheimer	alzheimer	PROPN
fnp-3806	2969	27	's	's	PART
fnp-3806	2969	28	disease	disease	NOUN
fnp-3806	2969	29	.	.	PUNCT
fnp-3806	2970	1	j	j	PROPN
fnp-3806	2970	2	alzheimers	alzheimers	PROPN
fnp-3806	2970	3	dis	dis	PROPN
fnp-3806	2970	4	2017;57:1157	2017;57:1157	PROPN
fnp-3806	2970	5	-	-	SYM
fnp-3806	2970	6	1170	1170	NUM
fnp-3806	2970	7	.	.	PUNCT
fnp-3806	2971	1	https://doi.org/10.3233/jad-161111	https://doi.org/10.3233/jad-161111	PROPN
fnp-3806	2971	2	uddin	uddin	PROPN
fnp-3806	2971	3	ms	ms	PROPN
fnp-3806	2971	4	,	,	PUNCT
fnp-3806	2971	5	mamun	mamun	PROPN
fnp-3806	2971	6	a	a	PROPN
fnp-3806	2971	7	,	,	PUNCT
fnp-3806	2971	8	rahman	rahman	PROPN
fnp-3806	2971	9	ma	ma	PROPN
fnp-3806	2971	10	,	,	PUNCT
fnp-3806	2971	11	et	et	PROPN
fnp-3806	2971	12	al	al	PROPN
fnp-3806	2971	13	.	.	PUNCT
fnp-3806	2972	1	emerging	emerge	VERB
fnp-3806	2972	2	proof	proof	NOUN
fnp-3806	2972	3	of	of	ADP
fnp-3806	2972	4	protein	protein	NOUN
fnp-3806	2972	5	misfolding	misfolding	NOUN
fnp-3806	2972	6	and	and	CCONJ
fnp-3806	2972	7	interactions	interaction	NOUN
fnp-3806	2972	8	in	in	ADP
fnp-3806	2972	9	multifactorial	multifactorial	ADJ
fnp-3806	2972	10	alzheimer	alzheimer	NOUN
fnp-3806	2972	11	's	's	PART
fnp-3806	2972	12	disease	disease	NOUN
fnp-3806	2972	13	.	.	PUNCT
fnp-3806	2973	1	curr	curr	PROPN
fnp-3806	2973	2	top	top	ADJ
fnp-3806	2973	3	med	med	ADJ
fnp-3806	2973	4	chem	chem	NOUN
fnp-3806	2973	5	2020;20:2380	2020;20:2380	NUM
fnp-3806	2973	6	-	-	SYM
fnp-3806	2973	7	2390	2390	NUM
fnp-3806	2973	8	.	.	PUNCT
fnp-3806	2974	1	https://doi.org/10.2174/1568026620666200601161703	https://doi.org/10.2174/1568026620666200601161703	PROPN
fnp-3806	2974	2	uddin	uddin	PROPN
fnp-3806	2974	3	ms	ms	PROPN
fnp-3806	2974	4	,	,	PUNCT
fnp-3806	2974	5	tewari	tewari	PROPN
fnp-3806	2974	6	d	d	PROPN
fnp-3806	2974	7	,	,	PUNCT
fnp-3806	2974	8	sharma	sharma	PROPN
fnp-3806	2974	9	g	g	PROPN
fnp-3806	2974	10	,	,	PUNCT
fnp-3806	2974	11	et	et	PROPN
fnp-3806	2974	12	al	al	PROPN
fnp-3806	2974	13	.	.	PUNCT
fnp-3806	2975	1	molecular	molecular	ADJ
fnp-3806	2975	2	mechanisms	mechanism	NOUN
fnp-3806	2975	3	of	of	ADP
fnp-3806	2975	4	er	er	INTJ
fnp-3806	2975	5	stress	stress	NOUN
fnp-3806	2975	6	and	and	CCONJ
fnp-3806	2975	7	upr	upr	NOUN
fnp-3806	2975	8	in	in	ADP
fnp-3806	2975	9	the	the	DET
fnp-3806	2975	10	pathogenesis	pathogenesis	NOUN
fnp-3806	2975	11	of	of	ADP
fnp-3806	2975	12	alzheimer	alzheimer	PROPN
fnp-3806	2975	13	's	's	PART
fnp-3806	2975	14	disease	disease	NOUN
fnp-3806	2975	15	.	.	PUNCT
fnp-3806	2976	1	mol	mol	ADP
fnp-3806	2976	2	neurobiol	neurobiol	PROPN
fnp-3806	2976	3	2020;57:2902	2020;57:2902	NUM
fnp-3806	2976	4	-	-	SYM
fnp-3806	2976	5	2919	2919	NUM
fnp-3806	2976	6	.	.	PUNCT
fnp-3806	2977	1	https://doi.org/10.1007/s12035-020-01929-y	https://doi.org/10.1007/s12035-020-01929-y	PROPN
fnp-3806	2977	2	nijholt	nijholt	PROPN
fnp-3806	2977	3	da	da	PROPN
fnp-3806	2977	4	,	,	PUNCT
fnp-3806	2977	5	de	de	PROPN
fnp-3806	2977	6	graaf	graaf	PROPN
fnp-3806	2977	7	tr	tr	VERB
fnp-3806	2977	8	,	,	PUNCT
fnp-3806	2977	9	van	van	PROPN
fnp-3806	2977	10	haastert	haastert	PROPN
fnp-3806	2977	11	es	es	PROPN
fnp-3806	2977	12	,	,	PUNCT
fnp-3806	2977	13	et	et	PROPN
fnp-3806	2977	14	al	al	PROPN
fnp-3806	2977	15	.	.	PUNCT
fnp-3806	2978	1	endoplasmic	endoplasmic	ADJ
fnp-3806	2978	2	reticulum	reticulum	NOUN
fnp-3806	2978	3	stress	stress	NOUN
fnp-3806	2978	4	activates	activate	VERB
fnp-3806	2978	5	autophagy	autophagy	NOUN
fnp-3806	2978	6	but	but	CCONJ
fnp-3806	2978	7	not	not	PART
fnp-3806	2978	8	the	the	DET
fnp-3806	2978	9	proteasome	proteasome	NOUN
fnp-3806	2978	10	in	in	ADP
fnp-3806	2978	11	neuronal	neuronal	ADJ
fnp-3806	2978	12	cells	cell	NOUN
fnp-3806	2978	13	:	:	PUNCT
fnp-3806	2978	14	implications	implication	NOUN
fnp-3806	2978	15	for	for	ADP
fnp-3806	2978	16	alzheimer	alzheimer	PROPN
fnp-3806	2978	17	's	's	PART
fnp-3806	2978	18	disease	disease	NOUN
fnp-3806	2978	19	.	.	PUNCT
fnp-3806	2979	1	cell	cell	NOUN
fnp-3806	2979	2	death	death	NOUN
fnp-3806	2979	3	differ	differ	VERB
fnp-3806	2979	4	2011;18:1071	2011;18:1071	NUM
fnp-3806	2979	5	-	-	SYM
fnp-3806	2979	6	1081	1081	NUM
fnp-3806	2979	7	.	.	PUNCT
fnp-3806	2980	1	https://doi.org/10.1038/cdd.2010.176	https://doi.org/10.1038/cdd.2010.176	NOUN
fnp-3806	2980	2	scheper	scheper	NOUN
fnp-3806	2980	3	w	w	PROPN
fnp-3806	2980	4	,	,	PUNCT
fnp-3806	2980	5	nijholt	nijholt	PROPN
fnp-3806	2980	6	da	da	PROPN
fnp-3806	2980	7	,	,	PUNCT
fnp-3806	2980	8	hoozemans	hoozemans	PROPN
fnp-3806	2980	9	jj	jj	PROPN
fnp-3806	2980	10	.	.	PUNCT
fnp-3806	2981	1	the	the	DET
fnp-3806	2981	2	unfolded	unfold	VERB
fnp-3806	2981	3	protein	protein	NOUN
fnp-3806	2981	4	response	response	NOUN
fnp-3806	2981	5	and	and	CCONJ
fnp-3806	2981	6	proteostasis	proteostasis	NOUN
fnp-3806	2981	7	in	in	ADP
fnp-3806	2981	8	alzheimer	alzheimer	PROPN
fnp-3806	2981	9	disease	disease	PROPN
fnp-3806	2981	10	:	:	PUNCT
fnp-3806	2981	11	preferential	preferential	ADJ
fnp-3806	2981	12	activation	activation	NOUN
fnp-3806	2981	13	of	of	ADP
fnp-3806	2981	14	autophagy	autophagy	NOUN
fnp-3806	2981	15	by	by	ADP
fnp-3806	2981	16	endoplasmic	endoplasmic	ADJ
fnp-3806	2981	17	reticulum	reticulum	NOUN
fnp-3806	2981	18	stress	stress	NOUN
fnp-3806	2981	19	.	.	PUNCT
fnp-3806	2982	1	autophagy	autophagy	ADJ
fnp-3806	2982	2	2011;7:910	2011;7:910	NOUN
fnp-3806	2982	3	-	-	SYM
fnp-3806	2982	4	911	911	NUM
fnp-3806	2982	5	.	.	PUNCT
fnp-3806	2982	6	https://doi.org/10.4161/auto.7.8.15761	https://doi.org/10.4161/auto.7.8.15761	PROPN
fnp-3806	2982	7	cai	cai	PROPN
fnp-3806	2982	8	y	y	PROPN
fnp-3806	2982	9	,	,	PUNCT
fnp-3806	2982	10	arikkath	arikkath	PROPN
fnp-3806	2982	11	j	j	PROPN
fnp-3806	2982	12	,	,	PUNCT
fnp-3806	2982	13	yang	yang	PROPN
fnp-3806	2982	14	l	l	PROPN
fnp-3806	2982	15	,	,	PUNCT
fnp-3806	2982	16	et	et	PROPN
fnp-3806	2982	17	al	al	PROPN
fnp-3806	2982	18	.	.	PROPN
fnp-3806	2982	19	interplay	interplay	NOUN
fnp-3806	2982	20	of	of	ADP
fnp-3806	2982	21	endoplasmic	endoplasmic	ADJ
fnp-3806	2982	22	reticulum	reticulum	NOUN
fnp-3806	2982	23	stress	stress	NOUN
fnp-3806	2982	24	and	and	CCONJ
fnp-3806	2982	25	autophagy	autophagy	VERB
fnp-3806	2982	26	in	in	ADP
fnp-3806	2982	27	neurodegenerative	neurodegenerative	ADJ
fnp-3806	2982	28	disorders	disorder	NOUN
fnp-3806	2982	29	.	.	PUNCT
fnp-3806	2983	1	autophagy	autophagy	VERB
fnp-3806	2983	2	2016;12:225	2016;12:225	NOUN
fnp-3806	2983	3	-	-	SYM
fnp-3806	2983	4	244	244	NUM
fnp-3806	2983	5	.	.	PUNCT
fnp-3806	2984	1	https://doi.org/10.1080/15548627.2015.1121360	https://doi.org/10.1080/15548627.2015.1121360	PROPN
fnp-3806	2985	1	nandi	nandi	PROPN
fnp-3806	2985	2	d	d	PROPN
fnp-3806	2985	3	,	,	PUNCT
fnp-3806	2985	4	tahiliani	tahiliani	PROPN
fnp-3806	2985	5	p	p	X
fnp-3806	2985	6	,	,	PUNCT
fnp-3806	2985	7	kumar	kumar	PROPN
fnp-3806	2985	8	a	a	PROPN
fnp-3806	2985	9	,	,	PUNCT
fnp-3806	2985	10	et	et	PROPN
fnp-3806	2985	11	al	al	PROPN
fnp-3806	2985	12	.	.	PUNCT
fnp-3806	2986	1	the	the	DET
fnp-3806	2986	2	ubiquitin	ubiquitin	ADJ
fnp-3806	2986	3	-	-	PUNCT
fnp-3806	2986	4	proteasome	proteasome	NOUN
fnp-3806	2986	5	system	system	NOUN
fnp-3806	2986	6	.	.	PUNCT
fnp-3806	2987	1	j	j	PROPN
fnp-3806	2987	2	biosci	biosci	PROPN
fnp-3806	2987	3	2006;31:137	2006;31:137	PROPN
fnp-3806	2987	4	-	-	SYM
fnp-3806	2987	5	155	155	NUM
fnp-3806	2987	6	.	.	PUNCT
fnp-3806	2987	7	https://doi.org/10.1007/bf02705243	https://doi.org/10.1007/bf02705243	X
fnp-3806	2987	8	wang	wang	PROPN
fnp-3806	2987	9	y	y	PROPN
fnp-3806	2987	10	,	,	PUNCT
fnp-3806	2987	11	le	le	X
fnp-3806	2987	12	wd	wd	PROPN
fnp-3806	2987	13	.	.	PUNCT
fnp-3806	2988	1	autophagy	autophagy	PROPN
fnp-3806	2988	2	and	and	CCONJ
fnp-3806	2988	3	ubiquitin	ubiquitin	ADJ
fnp-3806	2988	4	proteasome	proteasome	NOUN
fnp-3806	2988	5	system	system	NOUN
fnp-3806	2988	6	.	.	PUNCT
fnp-3806	2989	1	adv	adv	PROPN
fnp-3806	2989	2	exp	exp	NOUN
fnp-3806	2989	3	med	med	ADJ
fnp-3806	2989	4	biol	biol	NOUN
fnp-3806	2989	5	2019;1206:527	2019;1206:527	PROPN
fnp-3806	2989	6	-	-	SYM
fnp-3806	2989	7	550	550	NUM
fnp-3806	2989	8	.	.	PUNCT
fnp-3806	2990	1	https://doi.org/10.1007/978-981-15-0602-4_25	https://doi.org/10.1007/978-981-15-0602-4_25	PROPN
fnp-3806	2990	2	yu	yu	PROPN
fnp-3806	2990	3	l	l	PROPN
fnp-3806	2990	4	,	,	PUNCT
fnp-3806	2990	5	chen	chen	PROPN
fnp-3806	2990	6	y	y	PROPN
fnp-3806	2990	7	,	,	PUNCT
fnp-3806	2990	8	tooze	tooze	PROPN
fnp-3806	2990	9	sa	sa	PROPN
fnp-3806	2990	10	.	.	PUNCT
fnp-3806	2991	1	autophagy	autophagy	ADJ
fnp-3806	2991	2	pathway	pathway	NOUN
fnp-3806	2991	3	:	:	PUNCT
fnp-3806	2991	4	cellular	cellular	ADJ
fnp-3806	2991	5	and	and	CCONJ
fnp-3806	2991	6	molecular	molecular	ADJ
fnp-3806	2991	7	mechanisms	mechanism	NOUN
fnp-3806	2991	8	.	.	PUNCT
fnp-3806	2992	1	autophagy	autophagy	ADJ
fnp-3806	2992	2	2018;14:207	2018;14:207	NOUN
fnp-3806	2992	3	-	-	SYM
fnp-3806	2992	4	215	215	NUM
fnp-3806	2992	5	.	.	PUNCT
fnp-3806	2993	1	https://doi.org/10.1080/15548627.2017.1378838	https://doi.org/10.1080/15548627.2017.1378838	VERB
fnp-3806	2993	2	tekirdag	tekirdag	PROPN
fnp-3806	2993	3	k	k	PROPN
fnp-3806	2993	4	,	,	PUNCT
fnp-3806	2993	5	cuervo	cuervo	PROPN
fnp-3806	2993	6	am	be	AUX
fnp-3806	2993	7	.	.	PUNCT
fnp-3806	2994	1	chaperone	chaperone	NOUN
fnp-3806	2994	2	-	-	PUNCT
fnp-3806	2994	3	mediated	mediate	VERB
fnp-3806	2994	4	autophagy	autophagy	NOUN
fnp-3806	2994	5	and	and	CCONJ
fnp-3806	2994	6	endosomal	endosomal	ADJ
fnp-3806	2994	7	microautophagy	microautophagy	NOUN
fnp-3806	2994	8	:	:	PUNCT
fnp-3806	2994	9	joint	joint	NOUN
fnp-3806	2994	10	by	by	ADP
fnp-3806	2994	11	a	a	DET
fnp-3806	2994	12	chaperone	chaperone	NOUN
fnp-3806	2994	13	.	.	PUNCT
fnp-3806	2995	1	j	j	PROPN
fnp-3806	2995	2	biol	biol	PROPN
fnp-3806	2995	3	chem	chem	NOUN
fnp-3806	2995	4	2018	2018	NUM
fnp-3806	2995	5	;	;	PUNCT
fnp-3806	2995	6	293:5414	293:5414	NUM
fnp-3806	2995	7	-	-	SYM
fnp-3806	2995	8	5424	5424	NUM
fnp-3806	2995	9	.	.	PUNCT
fnp-3806	2996	1	https://doi.org/10.1074/jbc.r117.818237	https://doi.org/10.1074/jbc.r117.818237	INTJ
fnp-3806	2996	2	he	he	PRON
fnp-3806	2996	3	c	c	NOUN
fnp-3806	2996	4	,	,	PUNCT
fnp-3806	2996	5	klionsky	klionsky	ADJ
fnp-3806	2996	6	dj	dj	PROPN
fnp-3806	2996	7	.	.	PUNCT
fnp-3806	2996	8	regulation	regulation	NOUN
fnp-3806	2996	9	mechanisms	mechanism	NOUN
fnp-3806	2996	10	and	and	CCONJ
fnp-3806	2996	11	signaling	signal	VERB
fnp-3806	2996	12	pathways	pathway	NOUN
fnp-3806	2996	13	of	of	ADP
fnp-3806	2996	14	autophagy	autophagy	NOUN
fnp-3806	2996	15	.	.	PUNCT
fnp-3806	2997	1	annu	annu	PROPN
fnp-3806	2997	2	rev	rev	VERB
fnp-3806	2997	3	genet	genet	PROPN
fnp-3806	2997	4	2009	2009	NUM
fnp-3806	2997	5	;	;	PUNCT
fnp-3806	2997	6	43:67	43:67	NUM
fnp-3806	2997	7	-	-	SYM
fnp-3806	2997	8	93	93	NUM
fnp-3806	2997	9	.	.	PUNCT
fnp-3806	2998	1	https://doi.org/10.1146/annurev-genet-102808-114910	https://doi.org/10.1146/annurev-genet-102808-114910	VERB
fnp-3806	2998	2	mehrpour	mehrpour	PROPN
fnp-3806	2998	3	m	m	PROPN
fnp-3806	2998	4	,	,	PUNCT
fnp-3806	2998	5	esclatine	esclatine	X
fnp-3806	2998	6	a	a	NOUN
fnp-3806	2998	7	,	,	PUNCT
fnp-3806	2998	8	beau	beau	NOUN
fnp-3806	2998	9	i	i	PRON
fnp-3806	2998	10	,	,	PUNCT
fnp-3806	2998	11	et	et	PROPN
fnp-3806	2998	12	al	al	PROPN
fnp-3806	2998	13	.	.	PROPN
fnp-3806	2999	1	overview	overview	NOUN
fnp-3806	2999	2	of	of	ADP
fnp-3806	2999	3	macroautophagy	macroautophagy	ADJ
fnp-3806	2999	4	regulation	regulation	NOUN
fnp-3806	2999	5	in	in	ADP
fnp-3806	2999	6	mammalian	mammalian	ADJ
fnp-3806	2999	7	cells	cell	NOUN
fnp-3806	2999	8	.	.	PUNCT
fnp-3806	3000	1	cell	cell	NOUN
fnp-3806	3000	2	res	re	NOUN
fnp-3806	3000	3	2010	2010	NUM
fnp-3806	3000	4	;	;	PUNCT
fnp-3806	3000	5	20:748	20:748	NUM
fnp-3806	3000	6	-	-	SYM
fnp-3806	3000	7	762	762	NUM
fnp-3806	3000	8	.	.	PUNCT
fnp-3806	3001	1	https://doi.org/10.1038/cr.2010.82	https://doi.org/10.1038/cr.2010.82	PROPN
fnp-3806	3001	2	tanida	tanida	PROPN
fnp-3806	3001	3	i.	i.	PROPN
fnp-3806	3001	4	autophagosome	autophagosome	VERB
fnp-3806	3001	5	formation	formation	NOUN
fnp-3806	3001	6	and	and	CCONJ
fnp-3806	3001	7	molecular	molecular	ADJ
fnp-3806	3001	8	mechanism	mechanism	NOUN
fnp-3806	3001	9	of	of	ADP
fnp-3806	3001	10	autophagy	autophagy	NOUN
fnp-3806	3001	11	.	.	PUNCT
fnp-3806	3002	1	antioxid	antioxid	NOUN
fnp-3806	3002	2	redox	redox	NOUN
fnp-3806	3002	3	signal	signal	NOUN
fnp-3806	3002	4	2011	2011	NUM
fnp-3806	3002	5	;	;	PUNCT
fnp-3806	3002	6	14:2201	14:2201	NUM
fnp-3806	3002	7	-	-	SYM
fnp-3806	3002	8	2214	2214	NUM
fnp-3806	3002	9	.	.	PUNCT
fnp-3806	3003	1	https://doi.org/10.1089/ars.2010.3482	https://doi.org/10.1089/ars.2010.3482	PROPN
fnp-3806	3003	2	cataldo	cataldo	PROPN
fnp-3806	3003	3	am	am	PROPN
fnp-3806	3003	4	,	,	PUNCT
fnp-3806	3003	5	paskevich	paskevich	PROPN
fnp-3806	3003	6	pa	pa	PROPN
fnp-3806	3003	7	,	,	PUNCT
fnp-3806	3003	8	kominami	kominami	NOUN
fnp-3806	3003	9	e	e	PROPN
fnp-3806	3003	10	,	,	PUNCT
fnp-3806	3003	11	et	et	PROPN
fnp-3806	3003	12	al	al	PROPN
fnp-3806	3003	13	.	.	PROPN
fnp-3806	3003	14	lysosomal	lysosomal	ADJ
fnp-3806	3003	15	hydrolases	hydrolase	NOUN
fnp-3806	3003	16	of	of	ADP
fnp-3806	3003	17	different	different	ADJ
fnp-3806	3003	18	classes	class	NOUN
fnp-3806	3003	19	are	be	AUX
fnp-3806	3003	20	abnormally	abnormally	ADV
fnp-3806	3003	21	distributed	distribute	VERB
fnp-3806	3003	22	in	in	ADP
fnp-3806	3003	23	brains	brain	NOUN
fnp-3806	3003	24	of	of	ADP
fnp-3806	3003	25	patients	patient	NOUN
fnp-3806	3003	26	with	with	ADP
fnp-3806	3003	27	alzheimer	alzheimer	PROPN
fnp-3806	3003	28	disease	disease	NOUN
fnp-3806	3003	29	.	.	PUNCT
fnp-3806	3004	1	proc	proc	PROPN
fnp-3806	3004	2	natl	natl	PROPN
fnp-3806	3004	3	acad	acad	PROPN
fnp-3806	3004	4	sci	sci	PROPN
fnp-3806	3004	5	usa	usa	PROPN
fnp-3806	3004	6	1991;88:10998	1991;88:10998	PROPN
fnp-3806	3004	7	-	-	PUNCT
fnp-3806	3004	8	101002	101002	NUM
fnp-3806	3004	9	.	.	PUNCT
fnp-3806	3005	1	https://doi.org/10.1073/pnas.88.24.10998	https://doi.org/10.1073/pnas.88.24.10998	PROPN
fnp-3806	3005	2	yu	yu	PROPN
fnp-3806	3005	3	wh	wh	PROPN
fnp-3806	3005	4	,	,	PUNCT
fnp-3806	3005	5	cuervo	cuervo	PROPN
fnp-3806	3005	6	am	am	PROPN
fnp-3806	3005	7	,	,	PUNCT
fnp-3806	3005	8	kumar	kumar	PROPN
fnp-3806	3005	9	a	a	PROPN
fnp-3806	3005	10	,	,	PUNCT
fnp-3806	3005	11	et	et	PROPN
fnp-3806	3005	12	al	al	PROPN
fnp-3806	3005	13	.	.	PUNCT
fnp-3806	3006	1	macroautophagy	macroautophagy	PROPN
fnp-3806	3006	2	—	—	PUNCT
fnp-3806	3006	3	a	a	DET
fnp-3806	3006	4	novel	novel	ADJ
fnp-3806	3006	5	b	b	NOUN
fnp-3806	3006	6	-	-	PUNCT
fnp-3806	3006	7	amyloid	amyloid	NOUN
fnp-3806	3006	8	peptide	peptide	NOUN
fnp-3806	3006	9	-	-	PUNCT
fnp-3806	3006	10	generating	generate	VERB
fnp-3806	3006	11	pathway	pathway	NOUN
fnp-3806	3006	12	activated	activate	VERB
fnp-3806	3006	13	in	in	ADP
fnp-3806	3006	14	alzheimer	alzheimer	PROPN
fnp-3806	3006	15	’s	’s	PART
fnp-3806	3006	16	disease	disease	NOUN
fnp-3806	3006	17	.	.	PUNCT
fnp-3806	3007	1	j	j	PROPN
fnp-3806	3007	2	cell	cell	NOUN
fnp-3806	3007	3	biol	biol	PROPN
fnp-3806	3007	4	2005;171:87	2005;171:87	NOUN
fnp-3806	3007	5	-	-	SYM
fnp-3806	3007	6	98	98	NUM
fnp-3806	3007	7	.	.	PUNCT
fnp-3806	3008	1	https://doi.org/10.1083/jcb.200505082	https://doi.org/10.1083/jcb.200505082	PROPN
fnp-3806	3008	2	nixon	nixon	PROPN
fnp-3806	3008	3	ra	ra	PROPN
fnp-3806	3008	4	,	,	PUNCT
fnp-3806	3008	5	wegiel	wegiel	PROPN
fnp-3806	3008	6	j	j	PROPN
fnp-3806	3008	7	,	,	PUNCT
fnp-3806	3008	8	kumar	kumar	PROPN
fnp-3806	3008	9	a	a	PROPN
fnp-3806	3008	10	,	,	PUNCT
fnp-3806	3008	11	et	et	PROPN
fnp-3806	3008	12	al	al	PROPN
fnp-3806	3008	13	.	.	PROPN
fnp-3806	3008	14	extensive	extensive	ADJ
fnp-3806	3008	15	involvement	involvement	NOUN
fnp-3806	3008	16	of	of	ADP
fnp-3806	3008	17	autophagy	autophagy	NOUN
fnp-3806	3008	18	in	in	ADP
fnp-3806	3008	19	alzheimer	alzheimer	PROPN
fnp-3806	3008	20	disease	disease	PROPN
fnp-3806	3008	21	:	:	PUNCT
fnp-3806	3008	22	an	an	DET
fnp-3806	3008	23	immunoelectron	immunoelectron	ADJ
fnp-3806	3008	24	microscopy	microscopy	NOUN
fnp-3806	3008	25	study	study	NOUN
fnp-3806	3008	26	.	.	PUNCT
fnp-3806	3009	1	j	j	PROPN
fnp-3806	3009	2	neuropathol	neuropathol	PROPN
fnp-3806	3009	3	exp	exp	PROPN
fnp-3806	3009	4	neurol	neurol	PROPN
fnp-3806	3009	5	2005;64:113	2005;64:113	PROPN
fnp-3806	3009	6	-	-	SYM
fnp-3806	3009	7	122	122	NUM
fnp-3806	3009	8	.	.	PUNCT
fnp-3806	3010	1	https://doi.org/10.1093/jnen/64.2.113	https://doi.org/10.1093/jnen/64.2.113	PROPN
fnp-3806	3010	2	barrachina	barrachina	PROPN
fnp-3806	3010	3	m	m	PROPN
fnp-3806	3010	4	,	,	PUNCT
fnp-3806	3010	5	maes	maes	PROPN
fnp-3806	3010	6	t	t	PROPN
fnp-3806	3010	7	,	,	PUNCT
fnp-3806	3010	8	buesa	buesa	NOUN
fnp-3806	3010	9	c	c	NOUN
fnp-3806	3010	10	,	,	PUNCT
fnp-3806	3010	11	et	et	PROPN
fnp-3806	3010	12	al	al	PROPN
fnp-3806	3010	13	.	.	PROPN
fnp-3806	3011	1	up	up	ADP
fnp-3806	3011	2	-	-	PUNCT
fnp-3806	3011	3	regulation	regulation	NOUN
fnp-3806	3011	4	of	of	ADP
fnp-3806	3011	5	lysosome	lysosome	ADJ
fnp-3806	3011	6	associated	associate	VERB
fnp-3806	3011	7	-	-	PUNCT
fnp-3806	3011	8	membrane	membrane	NOUN
fnp-3806	3011	9	protein	protein	NOUN
fnp-3806	3011	10	1	1	NUM
fnp-3806	3011	11	(	(	PUNCT
fnp-3806	3011	12	lamp-1	lamp-1	NUM
fnp-3806	3011	13	)	)	PUNCT
fnp-3806	3011	14	in	in	ADP
fnp-3806	3011	15	alzheimer	alzheimer	PROPN
fnp-3806	3011	16	’s	’s	PART
fnp-3806	3011	17	disease	disease	NOUN
fnp-3806	3011	18	.	.	PUNCT
fnp-3806	3012	1	neuropathol	neuropathol	PROPN
fnp-3806	3012	2	appl	appl	PROPN
fnp-3806	3012	3	neurobiol	neurobiol	PROPN
fnp-3806	3012	4	2006;32:505	2006;32:505	PROPN
fnp-3806	3012	5	-	-	SYM
fnp-3806	3012	6	516	516	NUM
fnp-3806	3012	7	.	.	PUNCT
fnp-3806	3013	1	https://doi.org/10.1111/j.1365-2990.2006.00756.x	https://doi.org/10.1111/j.1365-2990.2006.00756.x	PROPN
fnp-3806	3013	2	cecarini	cecarini	PROPN
fnp-3806	3013	3	v	v	PROPN
fnp-3806	3013	4	,	,	PUNCT
fnp-3806	3013	5	ding	de	VERB
fnp-3806	3013	6	q	q	NOUN
fnp-3806	3013	7	,	,	PUNCT
fnp-3806	3013	8	keller	keller	PROPN
fnp-3806	3013	9	jn	jn	PROPN
fnp-3806	3013	10	.	.	PROPN
fnp-3806	3013	11	oxidative	oxidative	ADJ
fnp-3806	3013	12	inactivation	inactivation	NOUN
fnp-3806	3013	13	of	of	ADP
fnp-3806	3013	14	the	the	DET
fnp-3806	3013	15	proteasome	proteasome	NOUN
fnp-3806	3013	16	in	in	ADP
fnp-3806	3013	17	alzheimer	alzheimer	PROPN
fnp-3806	3013	18	’s	’s	PART
fnp-3806	3013	19	disease	disease	NOUN
fnp-3806	3013	20	.	.	PUNCT
fnp-3806	3014	1	free	free	ADJ
fnp-3806	3014	2	radic	radic	NOUN
fnp-3806	3014	3	res	re	NOUN
fnp-3806	3014	4	2007	2007	NUM
fnp-3806	3014	5	;	;	PUNCT
fnp-3806	3014	6	41	41	NUM
fnp-3806	3014	7	:	:	PUNCT
fnp-3806	3014	8	673	673	NUM
fnp-3806	3014	9	-	-	SYM
fnp-3806	3014	10	680	680	NUM
fnp-3806	3014	11	.	.	PUNCT
fnp-3806	3014	12	https://doi.org/10.1080/10715760701286159	https://doi.org/10.1080/10715760701286159	NOUN
fnp-3806	3015	1	pickford	pickford	PROPN
fnp-3806	3015	2	f	f	PROPN
fnp-3806	3015	3	,	,	PUNCT
fnp-3806	3015	4	masliah	masliah	PROPN
fnp-3806	3015	5	e	e	PROPN
fnp-3806	3015	6	,	,	PUNCT
fnp-3806	3015	7	britschgi	britschgi	PROPN
fnp-3806	3015	8	m	m	PROPN
fnp-3806	3015	9	,	,	PUNCT
fnp-3806	3015	10	et	et	PROPN
fnp-3806	3015	11	al	al	PROPN
fnp-3806	3015	12	.	.	PUNCT
fnp-3806	3016	1	the	the	DET
fnp-3806	3016	2	autophagy	autophagy	ADV
fnp-3806	3016	3	-	-	PUNCT
fnp-3806	3016	4	related	relate	VERB
fnp-3806	3016	5	protein	protein	NOUN
fnp-3806	3016	6	beclin	beclin	NOUN
fnp-3806	3016	7	1	1	NUM
fnp-3806	3016	8	shows	show	VERB
fnp-3806	3016	9	reduced	reduce	VERB
fnp-3806	3016	10	expression	expression	NOUN
fnp-3806	3016	11	in	in	ADP
fnp-3806	3016	12	early	early	ADJ
fnp-3806	3016	13	alzheimer	alzheimer	NOUN
fnp-3806	3016	14	disease	disease	NOUN
fnp-3806	3016	15	and	and	CCONJ
fnp-3806	3016	16	regulates	regulate	VERB
fnp-3806	3016	17	amyloid	amyloid	NOUN
fnp-3806	3016	18	β	β	NOUN
fnp-3806	3016	19	accumulation	accumulation	NOUN
fnp-3806	3016	20	in	in	ADP
fnp-3806	3016	21	mice	mouse	NOUN
fnp-3806	3016	22	.	.	PUNCT
fnp-3806	3017	1	j	j	PROPN
fnp-3806	3017	2	clin	clin	PROPN
fnp-3806	3017	3	invest	invest	VERB
fnp-3806	3017	4	2008	2008	NUM
fnp-3806	3017	5	;	;	PUNCT
fnp-3806	3017	6	118:2190–2199	118:2190–2199	NUM
fnp-3806	3017	7	.	.	PUNCT
fnp-3806	3018	1	https://doi.org/10.1172/jci33585	https://doi.org/10.1172/jci33585	X
fnp-3806	3018	2	lipinski	lipinski	PROPN
fnp-3806	3018	3	mm	mm	PROPN
fnp-3806	3018	4	,	,	PUNCT
fnp-3806	3018	5	zheng	zheng	PROPN
fnp-3806	3018	6	b	b	PROPN
fnp-3806	3018	7	,	,	PUNCT
fnp-3806	3018	8	lu	lu	PROPN
fnp-3806	3018	9	t	t	PROPN
fnp-3806	3018	10	,	,	PUNCT
fnp-3806	3018	11	et	et	PROPN
fnp-3806	3018	12	al	al	PROPN
fnp-3806	3018	13	.	.	PUNCT
fnp-3806	3018	14	genome	genome	NOUN
fnp-3806	3018	15	-	-	PUNCT
fnp-3806	3018	16	wide	wide	ADJ
fnp-3806	3018	17	analysis	analysis	NOUN
fnp-3806	3018	18	reveals	reveal	VERB
fnp-3806	3018	19	mechanisms	mechanism	NOUN
fnp-3806	3018	20	modulating	modulate	VERB
fnp-3806	3018	21	autophagy	autophagy	NOUN
fnp-3806	3018	22	in	in	ADP
fnp-3806	3018	23	normal	normal	ADJ
fnp-3806	3018	24	brain	brain	NOUN
fnp-3806	3018	25	aging	aging	NOUN
fnp-3806	3018	26	and	and	CCONJ
fnp-3806	3018	27	in	in	ADP
fnp-3806	3018	28	alzheimer	alzheimer	PROPN
fnp-3806	3018	29	's	's	PART
fnp-3806	3018	30	disease	disease	NOUN
fnp-3806	3018	31	.	.	PUNCT
fnp-3806	3019	1	proc	proc	PROPN
fnp-3806	3019	2	natl	natl	PROPN
fnp-3806	3019	3	acad	acad	PROPN
fnp-3806	3019	4	sci	sci	PROPN
fnp-3806	3019	5	usa	usa	PROPN
fnp-3806	3019	6	2010;107:14164	2010;107:14164	PROPN
fnp-3806	3019	7	-	-	SYM
fnp-3806	3019	8	14169	14169	NUM
fnp-3806	3019	9	.	.	PUNCT
fnp-3806	3020	1	https://doi.org/10.1073/pnas.1009485107	https://doi.org/10.1073/pnas.1009485107	ADJ
fnp-3806	3020	2	ghavami	ghavami	NOUN
fnp-3806	3020	3	s	s	NOUN
fnp-3806	3020	4	,	,	PUNCT
fnp-3806	3020	5	shojaei	shojaei	VERB
fnp-3806	3020	6	s	s	NOUN
fnp-3806	3020	7	,	,	PUNCT
fnp-3806	3020	8	yeganeh	yeganeh	PROPN
fnp-3806	3020	9	b	b	PROPN
fnp-3806	3020	10	,	,	PUNCT
fnp-3806	3020	11	et	et	PROPN
fnp-3806	3020	12	al	al	PROPN
fnp-3806	3020	13	.	.	PROPN
fnp-3806	3021	1	autophagy	autophagy	PROPN
fnp-3806	3021	2	and	and	CCONJ
fnp-3806	3021	3	apoptosis	apoptosis	NOUN
fnp-3806	3021	4	dysfunction	dysfunction	NOUN
fnp-3806	3021	5	in	in	ADP
fnp-3806	3021	6	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3021	7	disorders	disorder	NOUN
fnp-3806	3021	8	.	.	PUNCT
fnp-3806	3022	1	prog	prog	PROPN
fnp-3806	3022	2	neurobiol	neurobiol	PROPN
fnp-3806	3022	3	2014;112:24	2014;112:24	NUM
fnp-3806	3022	4	-	-	SYM
fnp-3806	3022	5	49	49	NUM
fnp-3806	3022	6	.	.	PUNCT
fnp-3806	3023	1	https://doi.org/10.1016/j.pneurobio.2013.10.004	https://doi.org/10.1016/j.pneurobio.2013.10.004	PROPN
fnp-3806	3023	2	uddin	uddin	PROPN
fnp-3806	3023	3	ms	ms	PROPN
fnp-3806	3023	4	,	,	PUNCT
fnp-3806	3023	5	stachowiak	stachowiak	PROPN
fnp-3806	3023	6	a	a	X
fnp-3806	3023	7	,	,	PUNCT
fnp-3806	3023	8	mamun	mamun	PROPN
fnp-3806	3023	9	aa	aa	PROPN
fnp-3806	3023	10	,	,	PUNCT
fnp-3806	3023	11	et	et	PROPN
fnp-3806	3023	12	al	al	PROPN
fnp-3806	3023	13	.	.	PROPN
fnp-3806	3024	1	autophagy	autophagy	PROPN
fnp-3806	3024	2	and	and	CCONJ
fnp-3806	3024	3	alzheimer	alzheimer	PROPN
fnp-3806	3024	4	's	's	PART
fnp-3806	3024	5	disease	disease	NOUN
fnp-3806	3024	6	:	:	PUNCT
fnp-3806	3024	7	from	from	ADP
fnp-3806	3024	8	molecular	molecular	ADJ
fnp-3806	3024	9	mechanisms	mechanism	NOUN
fnp-3806	3024	10	to	to	ADP
fnp-3806	3024	11	therapeutic	therapeutic	ADJ
fnp-3806	3024	12	implications	implication	NOUN
fnp-3806	3024	13	.	.	PUNCT
fnp-3806	3025	1	front	front	ADJ
fnp-3806	3025	2	aging	age	VERB
fnp-3806	3025	3	neurosci	neurosci	PROPN
fnp-3806	3025	4	2018;10:04	2018;10:04	NUM
fnp-3806	3025	5	.	.	PUNCT
fnp-3806	3026	1	https://doi.org/10.3389/fnagi.2018.00004	https://doi.org/10.3389/fnagi.2018.00004	PROPN
fnp-3806	3026	2	guo	guo	PROPN
fnp-3806	3026	3	f	f	PROPN
fnp-3806	3026	4	,	,	PUNCT
fnp-3806	3026	5	liu	liu	PROPN
fnp-3806	3026	6	x	x	PROPN
fnp-3806	3026	7	,	,	PUNCT
fnp-3806	3026	8	cai	cai	PROPN
fnp-3806	3026	9	h	h	PROPN
fnp-3806	3026	10	,	,	PUNCT
fnp-3806	3026	11	le	le	PROPN
fnp-3806	3026	12	w.	w.	PROPN
fnp-3806	3026	13	autophagy	autophagy	PROPN
fnp-3806	3026	14	in	in	ADP
fnp-3806	3026	15	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3026	16	diseases	disease	NOUN
fnp-3806	3026	17	:	:	PUNCT
fnp-3806	3026	18	pathogenesis	pathogenesis	NOUN
fnp-3806	3026	19	and	and	CCONJ
fnp-3806	3026	20	therapy	therapy	NOUN
fnp-3806	3026	21	.	.	PUNCT
fnp-3806	3027	1	brain	brain	NOUN
fnp-3806	3027	2	pathol	pathol	NOUN
fnp-3806	3027	3	2018;28:3	2018;28:3	NUM
fnp-3806	3027	4	-	-	SYM
fnp-3806	3027	5	13	13	NUM
fnp-3806	3027	6	.	.	PUNCT
fnp-3806	3028	1	https://doi.org/10.1111/bpa.12545	https://doi.org/10.1111/bpa.12545	PROPN
fnp-3806	3028	2	pradeepkiran	pradeepkiran	PROPN
fnp-3806	3028	3	ja	ja	PROPN
fnp-3806	3028	4	,	,	PUNCT
fnp-3806	3028	5	reddy	reddy	PROPN
fnp-3806	3028	6	ph	ph	PROPN
fnp-3806	3028	7	.	.	PROPN
fnp-3806	3028	8	defective	defective	ADJ
fnp-3806	3028	9	mitophagy	mitophagy	NOUN
fnp-3806	3028	10	in	in	ADP
fnp-3806	3028	11	alzheimer	alzheimer	PROPN
fnp-3806	3028	12	's	's	PART
fnp-3806	3028	13	disease	disease	NOUN
fnp-3806	3028	14	.	.	PUNCT
fnp-3806	3029	1	ageing	age	VERB
fnp-3806	3029	2	res	re	NOUN
fnp-3806	3029	3	rev	rev	X
fnp-3806	3029	4	2020;64:101191	2020;64:101191	NUM
fnp-3806	3029	5	.	.	PUNCT
fnp-3806	3030	1	https://doi.org/10.1016/j.arr.2020.101191	https://doi.org/10.1016/j.arr.2020.101191	PROPN
fnp-3806	3030	2	salminen	salminen	PROPN
fnp-3806	3030	3	a	a	PRON
fnp-3806	3030	4	,	,	PUNCT
fnp-3806	3030	5	kaarniranta	kaarniranta	PROPN
fnp-3806	3030	6	k	k	PROPN
fnp-3806	3030	7	,	,	PUNCT
fnp-3806	3030	8	kauppinen	kauppinen	PROPN
fnp-3806	3030	9	a	a	X
fnp-3806	3030	10	,	,	PUNCT
fnp-3806	3030	11	et	et	PROPN
fnp-3806	3030	12	al	al	PROPN
fnp-3806	3030	13	.	.	PROPN
fnp-3806	3031	1	impaired	impair	VERB
fnp-3806	3031	2	autophagy	autophagy	NOUN
fnp-3806	3031	3	and	and	CCONJ
fnp-3806	3031	4	app	app	NOUN
fnp-3806	3031	5	processing	processing	NOUN
fnp-3806	3031	6	in	in	ADP
fnp-3806	3031	7	alzheimer	alzheimer	PROPN
fnp-3806	3031	8	's	's	PART
fnp-3806	3031	9	disease	disease	NOUN
fnp-3806	3031	10	:	:	PUNCT
fnp-3806	3031	11	the	the	DET
fnp-3806	3031	12	potential	potential	ADJ
fnp-3806	3031	13	role	role	NOUN
fnp-3806	3031	14	of	of	ADP
fnp-3806	3031	15	beclin	beclin	NOUN
fnp-3806	3031	16	1	1	NUM
fnp-3806	3031	17	interactome	interactome	NOUN
fnp-3806	3031	18	.	.	PUNCT
fnp-3806	3032	1	prog	prog	PROPN
fnp-3806	3032	2	neurobiol	neurobiol	PROPN
fnp-3806	3032	3	2013;106	2013;106	NUM
fnp-3806	3032	4	-	-	PUNCT
fnp-3806	3032	5	107:33	107:33	NUM
fnp-3806	3032	6	-	-	SYM
fnp-3806	3032	7	54	54	NUM
fnp-3806	3032	8	.	.	PUNCT
fnp-3806	3033	1	https://doi.org/10.1016/j.pneurobio.2013.06.002	https://doi.org/10.1016/j.pneurobio.2013.06.002	PROPN
fnp-3806	3033	2	johnston	johnston	PROPN
fnp-3806	3033	3	-	-	PUNCT
fnp-3806	3033	4	carey	carey	PROPN
fnp-3806	3033	5	hk	hk	PROPN
fnp-3806	3033	6	,	,	PUNCT
fnp-3806	3033	7	pomatto	pomatto	PROPN
fnp-3806	3033	8	lc	lc	PROPN
fnp-3806	3033	9	,	,	PUNCT
fnp-3806	3033	10	davies	davie	VERB
fnp-3806	3033	11	kj.the	kj.the	DET
fnp-3806	3033	12	immunoproteasome	immunoproteasome	NOUN
fnp-3806	3033	13	in	in	ADP
fnp-3806	3033	14	oxidative	oxidative	ADJ
fnp-3806	3033	15	stress	stress	NOUN
fnp-3806	3033	16	,	,	PUNCT
fnp-3806	3033	17	aging	aging	NOUN
fnp-3806	3033	18	,	,	PUNCT
fnp-3806	3033	19	and	and	CCONJ
fnp-3806	3033	20	disease	disease	NOUN
fnp-3806	3033	21	.	.	PUNCT
fnp-3806	3034	1	crit	crit	PROPN
fnp-3806	3034	2	rev	rev	PROPN
fnp-3806	3034	3	biochem	biochem	PROPN
fnp-3806	3034	4	mol	mol	ADP
fnp-3806	3034	5	biol	biol	PROPN
fnp-3806	3034	6	2015;51:268	2015;51:268	NOUN
fnp-3806	3034	7	-	-	SYM
fnp-3806	3034	8	281	281	NUM
fnp-3806	3034	9	.	.	PUNCT
fnp-3806	3035	1	https://doi.org/10.3109/10409238	https://doi.org/10.3109/10409238	PART
fnp-3806	3036	1	2016.1172554	2016.1172554	NUM
fnp-3806	3036	2	.	.	PUNCT
fnp-3806	3037	1	lee	lee	PROPN
fnp-3806	3037	2	mj	mj	PROPN
fnp-3806	3037	3	,	,	PUNCT
fnp-3806	3037	4	lee	lee	PROPN
fnp-3806	3037	5	jh	jh	PROPN
fnp-3806	3037	6	,	,	PUNCT
fnp-3806	3037	7	rubinsztein	rubinsztein	PROPN
fnp-3806	3037	8	dc	dc	PROPN
fnp-3806	3037	9	.	.	PUNCT
fnp-3806	3038	1	tau	tau	PROPN
fnp-3806	3038	2	degradation	degradation	NOUN
fnp-3806	3038	3	:	:	PUNCT
fnp-3806	3038	4	the	the	DET
fnp-3806	3038	5	ubiquitin	ubiquitin	ADJ
fnp-3806	3038	6	-	-	PUNCT
fnp-3806	3038	7	proteasome	proteasome	NOUN
fnp-3806	3038	8	system	system	NOUN
fnp-3806	3038	9	versus	versus	ADP
fnp-3806	3038	10	the	the	DET
fnp-3806	3038	11	autophagy	autophagy	ADJ
fnp-3806	3038	12	-	-	PUNCT
fnp-3806	3038	13	lysosome	lysosome	NOUN
fnp-3806	3038	14	system	system	NOUN
fnp-3806	3038	15	.	.	PUNCT
fnp-3806	3039	1	prog	prog	PROPN
fnp-3806	3039	2	neurobiol	neurobiol	PROPN
fnp-3806	3039	3	2013	2013	NUM
fnp-3806	3039	4	;	;	PUNCT
fnp-3806	3039	5	105	105	NUM
fnp-3806	3039	6	:	:	PUNCT
fnp-3806	3039	7	49–59	49–59	NOUN
fnp-3806	3039	8	.	.	PUNCT
fnp-3806	3040	1	https://doi.org/10.1016/j.pneurobio	https://doi.org/10.1016/j.pneurobio	PROPN
fnp-3806	3040	2	2013.03.001	2013.03.001	PROPN
fnp-3806	3040	3	.	.	PUNCT
fnp-3806	3041	1	riederer	riederer	PROPN
fnp-3806	3041	2	bm	bm	PROPN
fnp-3806	3041	3	,	,	PUNCT
fnp-3806	3041	4	leuba	leuba	PROPN
fnp-3806	3041	5	g	g	PROPN
fnp-3806	3041	6	,	,	PUNCT
fnp-3806	3041	7	vernay	vernay	NOUN
fnp-3806	3041	8	a	a	X
fnp-3806	3041	9	,	,	PUNCT
fnp-3806	3041	10	et	et	PROPN
fnp-3806	3041	11	al	al	PROPN
fnp-3806	3041	12	.	.	PUNCT
fnp-3806	3042	1	the	the	DET
fnp-3806	3042	2	role	role	NOUN
fnp-3806	3042	3	of	of	ADP
fnp-3806	3042	4	the	the	DET
fnp-3806	3042	5	ubiquitin	ubiquitin	ADJ
fnp-3806	3042	6	proteasome	proteasome	NOUN
fnp-3806	3042	7	system	system	NOUN
fnp-3806	3042	8	in	in	ADP
fnp-3806	3042	9	alzheimer	alzheimer	PROPN
fnp-3806	3042	10	’s	’s	PART
fnp-3806	3042	11	disease	disease	NOUN
fnp-3806	3042	12	.	.	PUNCT
fnp-3806	3043	1	exp	exp	NOUN
fnp-3806	3043	2	biol	biol	PROPN
fnp-3806	3043	3	med	me	VERB
fnp-3806	3043	4	2011;236:268	2011;236:268	NUM
fnp-3806	3043	5	-	-	SYM
fnp-3806	3043	6	276	276	NUM
fnp-3806	3043	7	.	.	PUNCT
fnp-3806	3044	1	https://doi.org/10.1258/ebm.2010.010327	https://doi.org/10.1258/ebm.2010.010327	NOUN
fnp-3806	3044	2	tramutola	tramutola	PROPN
fnp-3806	3045	1	a	a	PROPN
fnp-3806	3045	2	,	,	PUNCT
fnp-3806	3045	3	di	di	X
fnp-3806	3045	4	domenico	domenico	PROPN
fnp-3806	3045	5	f	f	PROPN
fnp-3806	3045	6	,	,	PUNCT
fnp-3806	3045	7	barone	barone	PROPN
fnp-3806	3045	8	e	e	PROPN
fnp-3806	3045	9	,	,	PUNCT
fnp-3806	3045	10	et	et	PROPN
fnp-3806	3045	11	al	al	PROPN
fnp-3806	3045	12	.	.	PUNCT
fnp-3806	3045	13	polyubiquitinylation	polyubiquitinylation	NOUN
fnp-3806	3045	14	profile	profile	NOUN
fnp-3806	3045	15	in	in	ADP
fnp-3806	3045	16	down	down	ADP
fnp-3806	3045	17	syndrome	syndrome	NOUN
fnp-3806	3045	18	brain	brain	NOUN
fnp-3806	3045	19	before	before	ADP
fnp-3806	3045	20	and	and	CCONJ
fnp-3806	3045	21	after	after	ADP
fnp-3806	3045	22	the	the	DET
fnp-3806	3045	23	development	development	NOUN
fnp-3806	3045	24	of	of	ADP
fnp-3806	3045	25	alzheimer	alzheimer	PROPN
fnp-3806	3045	26	neuropathology	neuropathology	PROPN
fnp-3806	3045	27	.	.	PUNCT
fnp-3806	3046	1	antioxid	antioxid	PROPN
fnp-3806	3046	2	redox	redox	NOUN
fnp-3806	3046	3	signal	signal	NOUN
fnp-3806	3046	4	2017;26:280	2017;26:280	PROPN
fnp-3806	3046	5	-	-	SYM
fnp-3806	3046	6	298	298	NUM
fnp-3806	3046	7	.	.	PUNCT
fnp-3806	3047	1	https://doi.org/10.1089/ars.2016.6686	https://doi.org/10.1089/ars.2016.6686	PROPN
fnp-3806	3047	2	weng	weng	PROPN
fnp-3806	3047	3	fl	fl	PROPN
fnp-3806	3047	4	,	,	PUNCT
fnp-3806	3047	5	he	he	PRON
fnp-3806	3047	6	l.	l.	PROPN
fnp-3806	3047	7	disrupted	disrupt	VERB
fnp-3806	3047	8	ubiquitin	ubiquitin	ADJ
fnp-3806	3047	9	proteasome	proteasome	NOUN
fnp-3806	3047	10	system	system	NOUN
fnp-3806	3047	11	underlying	underlie	VERB
fnp-3806	3047	12	tau	tau	PROPN
fnp-3806	3047	13	accumulation	accumulation	NOUN
fnp-3806	3047	14	in	in	ADP
fnp-3806	3047	15	alzheimer	alzheimer	PROPN
fnp-3806	3047	16	's	's	PART
fnp-3806	3047	17	disease	disease	NOUN
fnp-3806	3047	18	.	.	PUNCT
fnp-3806	3048	1	neurobiol	neurobiol	ADJ
fnp-3806	3048	2	aging	age	VERB
fnp-3806	3048	3	2021;99:79	2021;99:79	NUM
fnp-3806	3048	4	-	-	SYM
fnp-3806	3048	5	85	85	NUM
fnp-3806	3048	6	.	.	PUNCT
fnp-3806	3049	1	https://doi.org/10.1016/j.neurobiolaging.2020.11.015	https://doi.org/10.1016/j.neurobiolaging.2020.11.015	NUM
fnp-3806	3049	2	ferrer	ferrer	PROPN
fnp-3806	3049	3	i	i	PRON
fnp-3806	3049	4	,	,	PUNCT
fnp-3806	3049	5	santpere	santpere	ADV
fnp-3806	3049	6	g	g	PROPN
fnp-3806	3049	7	,	,	PUNCT
fnp-3806	3049	8	van	van	PROPN
fnp-3806	3049	9	leeuwen	leeuwen	PROPN
fnp-3806	3049	10	fw	fw	PROPN
fnp-3806	3049	11	.	.	PROPN
fnp-3806	3049	12	argyrophilic	argyrophilic	ADJ
fnp-3806	3049	13	grain	grain	NOUN
fnp-3806	3049	14	disease	disease	NOUN
fnp-3806	3049	15	.	.	PUNCT
fnp-3806	3050	1	brain	brain	NOUN
fnp-3806	3050	2	2008;131:1416	2008;131:1416	NUM
fnp-3806	3050	3	-	-	SYM
fnp-3806	3050	4	1432	1432	NUM
fnp-3806	3050	5	.	.	PUNCT
fnp-3806	3051	1	https://doi.org/10.1093/brain/awm305	https://doi.org/10.1093/brain/awm305	ADJ
fnp-3806	3051	2	tank	tank	NOUN
fnp-3806	3051	3	em	em	PRON
fnp-3806	3051	4	,	,	PUNCT
fnp-3806	3051	5	true	true	ADJ
fnp-3806	3051	6	hl	hl	NOUN
fnp-3806	3051	7	.	.	PUNCT
fnp-3806	3052	1	disease	disease	NOUN
fnp-3806	3052	2	-	-	PUNCT
fnp-3806	3052	3	associated	associate	VERB
fnp-3806	3052	4	mutant	mutant	ADJ
fnp-3806	3052	5	ubiquitin	ubiquitin	NOUN
fnp-3806	3052	6	causes	cause	VERB
fnp-3806	3052	7	proteasomal	proteasomal	ADJ
fnp-3806	3052	8	impairment	impairment	NOUN
fnp-3806	3052	9	and	and	CCONJ
fnp-3806	3052	10	enhances	enhance	VERB
fnp-3806	3052	11	the	the	DET
fnp-3806	3052	12	toxicity	toxicity	NOUN
fnp-3806	3052	13	of	of	ADP
fnp-3806	3052	14	protein	protein	NOUN
fnp-3806	3052	15	aggregates	aggregate	NOUN
fnp-3806	3052	16	.	.	PUNCT
fnp-3806	3053	1	plos	plos	PROPN
fnp-3806	3053	2	genet	genet	PROPN
fnp-3806	3053	3	2009;5	2009;5	NUM
fnp-3806	3053	4	:	:	PUNCT
fnp-3806	3053	5	e1000382	e1000382	VERB
fnp-3806	3053	6	.	.	PUNCT
fnp-3806	3054	1	chadwick	chadwick	PROPN
fnp-3806	3054	2	l	l	PROPN
fnp-3806	3054	3	,	,	PUNCT
fnp-3806	3054	4	gentle	gentle	ADJ
fnp-3806	3054	5	l	l	NOUN
fnp-3806	3054	6	,	,	PUNCT
fnp-3806	3054	7	strachan	strachan	PROPN
fnp-3806	3054	8	j	j	PROPN
fnp-3806	3054	9	,	,	PUNCT
fnp-3806	3054	10	et	et	PROPN
fnp-3806	3054	11	al	al	PROPN
fnp-3806	3054	12	.	.	PROPN
fnp-3806	3054	13	review	review	PROPN
fnp-3806	3054	14	:	:	PUNCT
fnp-3806	3054	15	unchained	unchained	PROPN
fnp-3806	3054	16	maladie	maladie	PROPN
fnp-3806	3054	17	a	a	DET
fnp-3806	3054	18	reassessment	reassessment	NOUN
fnp-3806	3054	19	of	of	ADP
fnp-3806	3054	20	the	the	DET
fnp-3806	3054	21	role	role	NOUN
fnp-3806	3054	22	of	of	ADP
fnp-3806	3054	23	ubb(+1	ubb(+1	ADV
fnp-3806	3054	24	)	)	PUNCT
fnp-3806	3054	25	-capped	-cappe	VERB
fnp-3806	3054	26	polyubiquitin	polyubiquitin	ADJ
fnp-3806	3054	27	chains	chain	NOUN
fnp-3806	3054	28	in	in	ADP
fnp-3806	3054	29	alzheimer	alzheimer	PROPN
fnp-3806	3054	30	's	's	PART
fnp-3806	3054	31	disease	disease	NOUN
fnp-3806	3054	32	.	.	PUNCT
fnp-3806	3055	1	neuropathol	neuropathol	PROPN
fnp-3806	3055	2	appl	appl	PROPN
fnp-3806	3055	3	neurobiol	neurobiol	PROPN
fnp-3806	3055	4	2012;38:118	2012;38:118	PROPN
fnp-3806	3055	5	-	-	SYM
fnp-3806	3055	6	131	131	NUM
fnp-3806	3055	7	.	.	PUNCT
fnp-3806	3056	1	https://doi.org/10.1111/j.1365-2990.2011.01236.x	https://doi.org/10.1111/j.1365-2990.2011.01236.x	PROPN
fnp-3806	3056	2	gentier	gentier	PROPN
fnp-3806	3056	3	rj	rj	PROPN
fnp-3806	3056	4	,	,	PUNCT
fnp-3806	3056	5	van	van	PROPN
fnp-3806	3056	6	leeuwen	leeuwen	PROPN
fnp-3806	3056	7	fw	fw	PROPN
fnp-3806	3056	8	.	.	PROPN
fnp-3806	3056	9	misframed	misframed	PROPN
fnp-3806	3056	10	ubiquitin	ubiquitin	NOUN
fnp-3806	3056	11	and	and	CCONJ
fnp-3806	3056	12	impaired	impaired	ADJ
fnp-3806	3056	13	protein	protein	NOUN
fnp-3806	3056	14	quality	quality	NOUN
fnp-3806	3056	15	control	control	NOUN
fnp-3806	3056	16	:	:	PUNCT
fnp-3806	3056	17	an	an	DET
fnp-3806	3056	18	early	early	ADJ
fnp-3806	3056	19	event	event	NOUN
fnp-3806	3056	20	in	in	ADP
fnp-3806	3056	21	alzheimer	alzheimer	PROPN
fnp-3806	3056	22	's	's	PART
fnp-3806	3056	23	disease	disease	NOUN
fnp-3806	3056	24	.	.	PUNCT
fnp-3806	3057	1	front	front	NOUN
fnp-3806	3057	2	mol	mol	ADP
fnp-3806	3057	3	neurosci	neurosci	PROPN
fnp-3806	3057	4	2015;8:47	2015;8:47	X
fnp-3806	3057	5	.	.	PUNCT
fnp-3806	3058	1	https://doi.org/10.3389/fnmol.2015.00047	https://doi.org/10.3389/fnmol.2015.00047	PROPN
fnp-3806	3058	2	van	van	PROPN
fnp-3806	3058	3	tijn	tijn	PROPN
fnp-3806	3058	4	p	p	NOUN
fnp-3806	3058	5	,	,	PUNCT
fnp-3806	3058	6	dennissen	dennissen	PROPN
fnp-3806	3058	7	fj	fj	PROPN
fnp-3806	3058	8	,	,	PUNCT
fnp-3806	3058	9	gentier	gentier	PROPN
fnp-3806	3058	10	rj	rj	PROPN
fnp-3806	3058	11	,	,	PUNCT
fnp-3806	3058	12	et	et	PROPN
fnp-3806	3058	13	al	al	PROPN
fnp-3806	3058	14	.	.	PROPN
fnp-3806	3059	1	mutant	mutant	ADJ
fnp-3806	3059	2	ubiquitin	ubiquitin	NOUN
fnp-3806	3059	3	decreases	decrease	VERB
fnp-3806	3059	4	β	β	NOUN
fnp-3806	3059	5	-	-	ADJ
fnp-3806	3059	6	amyloid	amyloid	ADJ
fnp-3806	3059	7	plaque	plaque	NOUN
fnp-3806	3059	8	formation	formation	NOUN
fnp-3806	3059	9	in	in	ADP
fnp-3806	3059	10	a	a	DET
fnp-3806	3059	11	transgenic	transgenic	NOUN
fnp-3806	3059	12	mouse	mouse	NOUN
fnp-3806	3059	13	model	model	NOUN
fnp-3806	3059	14	of	of	ADP
fnp-3806	3059	15	alzheimer	alzheimer	PROPN
fnp-3806	3059	16	’s	’s	PART
fnp-3806	3059	17	disease	disease	NOUN
fnp-3806	3059	18	.	.	PUNCT
fnp-3806	3060	1	neurochem	neurochem	PROPN
fnp-3806	3060	2	int	int	VERB
fnp-3806	3060	3	2012;61:739	2012;61:739	NUM
fnp-3806	3060	4	-	-	SYM
fnp-3806	3060	5	748	748	NUM
fnp-3806	3060	6	.	.	PUNCT
fnp-3806	3061	1	https://doi.org/10.1016/j.neuint.2012.07.007	https://doi.org/10.1016/j.neuint.2012.07.007	PROPN
fnp-3806	3061	2	verheijen	verheijen	PROPN
fnp-3806	3061	3	bm	bm	PROPN
fnp-3806	3061	4	,	,	PUNCT
fnp-3806	3061	5	stevens	stevens	PROPN
fnp-3806	3061	6	jaa	jaa	PROPN
fnp-3806	3061	7	,	,	PUNCT
fnp-3806	3061	8	gentier	gentier	NOUN
fnp-3806	3061	9	rjg	rjg	PROPN
fnp-3806	3061	10	,	,	PUNCT
fnp-3806	3061	11	et	et	PROPN
fnp-3806	3061	12	al	al	PROPN
fnp-3806	3061	13	.	.	PUNCT
fnp-3806	3062	1	paradoxical	paradoxical	ADJ
fnp-3806	3062	2	effects	effect	NOUN
fnp-3806	3062	3	of	of	ADP
fnp-3806	3062	4	mutant	mutant	ADJ
fnp-3806	3062	5	ubiquitin	ubiquitin	NOUN
fnp-3806	3062	6	on	on	ADP
fnp-3806	3062	7	aβ	aβ	DET
fnp-3806	3062	8	plaque	plaque	NOUN
fnp-3806	3062	9	formation	formation	NOUN
fnp-3806	3062	10	in	in	ADP
fnp-3806	3062	11	an	an	DET
fnp-3806	3062	12	alzheimer	alzheimer	PROPN
fnp-3806	3062	13	mouse	mouse	NOUN
fnp-3806	3062	14	model	model	NOUN
fnp-3806	3062	15	.	.	PUNCT
fnp-3806	3063	1	neurobiol	neurobiol	PROPN
fnp-3806	3063	2	aging	age	VERB
fnp-3806	3063	3	2018;72:62	2018;72:62	NUM
fnp-3806	3063	4	-	-	SYM
fnp-3806	3063	5	71	71	NUM
fnp-3806	3063	6	.	.	PUNCT
fnp-3806	3064	1	https://doi.org/10.1016/j.neurobiolaging.2018.08.011	https://doi.org/10.1016/j.neurobiolaging.2018.08.011	PROPN
fnp-3806	3064	2	ferrer	ferrer	PROPN
fnp-3806	3064	3	i	i	PROPN
fnp-3806	3064	4	,	,	PUNCT
fnp-3806	3064	5	boada	boada	PROPN
fnp-3806	3064	6	rovira	rovira	PROPN
fnp-3806	3064	7	m	m	PROPN
fnp-3806	3064	8	,	,	PUNCT
fnp-3806	3064	9	sanchez	sanchez	PROPN
fnp-3806	3064	10	guerra	guerra	PROPN
fnp-3806	3064	11	ml	ml	PROPN
fnp-3806	3064	12	,	,	PUNCT
fnp-3806	3064	13	et	et	PROPN
fnp-3806	3064	14	al	al	PROPN
fnp-3806	3064	15	.	.	PROPN
fnp-3806	3064	16	neuropathology	neuropathology	NOUN
fnp-3806	3064	17	and	and	CCONJ
fnp-3806	3064	18	pathogenesis	pathogenesis	NOUN
fnp-3806	3064	19	of	of	ADP
fnp-3806	3064	20	encephalitis	encephalitis	NOUN
fnp-3806	3064	21	following	follow	VERB
fnp-3806	3064	22	amyloid	amyloid	NOUN
fnp-3806	3064	23	-	-	PUNCT
fnp-3806	3064	24	beta	beta	NOUN
fnp-3806	3064	25	immunization	immunization	NOUN
fnp-3806	3064	26	in	in	ADP
fnp-3806	3064	27	alzheimer	alzheimer	PROPN
fnp-3806	3064	28	’s	’s	PART
fnp-3806	3064	29	disease	disease	NOUN
fnp-3806	3064	30	.	.	PUNCT
fnp-3806	3065	1	brain	brain	NOUN
fnp-3806	3065	2	pathol	pathol	NOUN
fnp-3806	3065	3	2004;14:11	2004;14:11	NUM
fnp-3806	3065	4	-	-	SYM
fnp-3806	3065	5	20	20	NUM
fnp-3806	3065	6	.	.	PUNCT
fnp-3806	3066	1	https://doi.org/10.1111/j.1750-3639.2004.tb00493.x	https://doi.org/10.1111/j.1750-3639.2004.tb00493.x	PROPN
fnp-3806	3066	2	aso	aso	PROPN
fnp-3806	3066	3	e	e	PROPN
fnp-3806	3066	4	,	,	PUNCT
fnp-3806	3066	5	lomoio	lomoio	X
fnp-3806	3066	6	s	s	PROPN
fnp-3806	3066	7	,	,	PUNCT
fnp-3806	3066	8	lópez	lópez	PROPN
fnp-3806	3066	9	-	-	PUNCT
fnp-3806	3066	10	gonzález	gonzález	PROPN
fnp-3806	3066	11	i	i	PRON
fnp-3806	3066	12	,	,	PUNCT
fnp-3806	3066	13	et	et	PROPN
fnp-3806	3066	14	al	al	PROPN
fnp-3806	3066	15	.	.	PUNCT
fnp-3806	3066	16	amyloid	amyloid	NOUN
fnp-3806	3066	17	generation	generation	NOUN
fnp-3806	3066	18	and	and	CCONJ
fnp-3806	3066	19	dysfunctional	dysfunctional	ADJ
fnp-3806	3066	20	immunoprotasome	immunoprotasome	ADJ
fnp-3806	3066	21	activation	activation	NOUN
fnp-3806	3066	22	with	with	ADP
fnp-3806	3066	23	disease	disease	NOUN
fnp-3806	3066	24	progression	progression	NOUN
fnp-3806	3066	25	in	in	ADP
fnp-3806	3066	26	animal	animal	NOUN
fnp-3806	3066	27	model	model	NOUN
fnp-3806	3066	28	of	of	ADP
fnp-3806	3066	29	familial	familial	ADJ
fnp-3806	3066	30	alzheimer	alzheimer	PROPN
fnp-3806	3066	31	’s	’s	PART
fnp-3806	3066	32	disease	disease	NOUN
fnp-3806	3066	33	.	.	PUNCT
fnp-3806	3067	1	brain	brain	NOUN
fnp-3806	3067	2	pathol	pathol	NOUN
fnp-3806	3067	3	2012;22:636	2012;22:636	NOUN
fnp-3806	3067	4	-	-	SYM
fnp-3806	3067	5	653	653	NUM
fnp-3806	3067	6	.	.	PUNCT
fnp-3806	3068	1	https://doi.org/10.1111/j.1750-3639.2011.00560.x	https://doi.org/10.1111/j.1750-3639.2011.00560.x	PROPN
fnp-3806	3068	2	orre	orre	PROPN
fnp-3806	3068	3	m	m	PROPN
fnp-3806	3068	4	,	,	PUNCT
fnp-3806	3068	5	kamphuis	kamphuis	PROPN
fnp-3806	3068	6	w	w	PROPN
fnp-3806	3068	7	,	,	PUNCT
fnp-3806	3068	8	dooves	doove	NOUN
fnp-3806	3068	9	s	s	PROPN
fnp-3806	3068	10	,	,	PUNCT
fnp-3806	3068	11	et	et	PROPN
fnp-3806	3068	12	al	al	PROPN
fnp-3806	3068	13	.	.	PROPN
fnp-3806	3068	14	reactive	reactive	PROPN
fnp-3806	3068	15	glia	glia	PROPN
fnp-3806	3068	16	show	show	VERB
fnp-3806	3068	17	increased	increase	VERB
fnp-3806	3068	18	immunoproteasome	immunoproteasome	NOUN
fnp-3806	3068	19	activity	activity	NOUN
fnp-3806	3068	20	in	in	ADP
fnp-3806	3068	21	alzheimer	alzheimer	PROPN
fnp-3806	3068	22	's	's	PART
fnp-3806	3068	23	disease	disease	NOUN
fnp-3806	3068	24	.	.	PUNCT
fnp-3806	3069	1	brain	brain	NOUN
fnp-3806	3069	2	2013;136	2013;136	NUM
fnp-3806	3069	3	:	:	PUNCT
fnp-3806	3069	4	1415	1415	NUM
fnp-3806	3069	5	-	-	SYM
fnp-3806	3069	6	1431	1431	NUM
fnp-3806	3069	7	.	.	PUNCT
fnp-3806	3070	1	https://doi.org/10.1093/brain/awt083	https://doi.org/10.1093/brain/awt083	NOUN
fnp-3806	3070	2	grimm	grimm	PROPN
fnp-3806	3070	3	s	s	PROPN
fnp-3806	3070	4	,	,	PUNCT
fnp-3806	3070	5	ott	ott	PROPN
fnp-3806	3070	6	c	c	PROPN
fnp-3806	3070	7	,	,	PUNCT
fnp-3806	3070	8	hörlacher	hörlacher	PROPN
fnp-3806	3070	9	m	m	PROPN
fnp-3806	3070	10	,	,	PUNCT
fnp-3806	3070	11	et	et	PROPN
fnp-3806	3070	12	al	al	PROPN
fnp-3806	3070	13	.	.	PROPN
fnp-3806	3071	1	advanced	advanced	ADJ
fnp-3806	3071	2	-	-	PUNCT
fnp-3806	3071	3	glycation	glycation	NOUN
fnp-3806	3071	4	-	-	PUNCT
fnp-3806	3071	5	end	end	NOUN
fnp-3806	3071	6	-	-	PUNCT
fnp-3806	3071	7	product	product	NOUN
fnp-3806	3071	8	-	-	PUNCT
fnp-3806	3071	9	induced	induce	VERB
fnp-3806	3071	10	formation	formation	NOUN
fnp-3806	3071	11	of	of	ADP
fnp-3806	3071	12	immunoproteasomes	immunoproteasome	NOUN
fnp-3806	3071	13	:	:	PUNCT
fnp-3806	3071	14	involvement	involvement	NOUN
fnp-3806	3071	15	of	of	ADP
fnp-3806	3071	16	rage	rage	NOUN
fnp-3806	3071	17	and	and	CCONJ
fnp-3806	3071	18	jak2	jak2	PROPN
fnp-3806	3071	19	/	/	SYM
fnp-3806	3071	20	stat1	stat1	PROPN
fnp-3806	3071	21	.	.	PUNCT
fnp-3806	3072	1	biochem	biochem	PROPN
fnp-3806	3072	2	j	j	PROPN
fnp-3806	3072	3	2012;448:127	2012;448:127	NUM
fnp-3806	3072	4	-	-	SYM
fnp-3806	3072	5	139	139	NUM
fnp-3806	3072	6	.	.	PUNCT
fnp-3806	3073	1	https://doi.org/10.1042/bj20120298	https://doi.org/10.1042/bj20120298	PROPN
fnp-3806	3073	2	thal	thal	PROPN
fnp-3806	3073	3	dr	dr	PROPN
fnp-3806	3073	4	,	,	PUNCT
fnp-3806	3073	5	del	del	PROPN
fnp-3806	3073	6	tredici	tredici	PROPN
fnp-3806	3073	7	k	k	PROPN
fnp-3806	3073	8	,	,	PUNCT
fnp-3806	3073	9	ludolph	ludolph	PROPN
fnp-3806	3073	10	ac	ac	PROPN
fnp-3806	3073	11	,	,	PUNCT
fnp-3806	3073	12	et	et	PROPN
fnp-3806	3073	13	al	al	PROPN
fnp-3806	3073	14	.	.	PUNCT
fnp-3806	3073	15	stages	stage	NOUN
fnp-3806	3073	16	of	of	ADP
fnp-3806	3073	17	granulovacuolar	granulovacuolar	ADJ
fnp-3806	3073	18	degeneration	degeneration	NOUN
fnp-3806	3073	19	:	:	PUNCT
fnp-3806	3073	20	their	their	PRON
fnp-3806	3073	21	relation	relation	NOUN
fnp-3806	3073	22	to	to	ADP
fnp-3806	3073	23	alzheimer	alzheimer	PROPN
fnp-3806	3073	24	's	's	PART
fnp-3806	3073	25	disease	disease	NOUN
fnp-3806	3073	26	and	and	CCONJ
fnp-3806	3073	27	chronic	chronic	ADJ
fnp-3806	3073	28	stress	stress	NOUN
fnp-3806	3073	29	response	response	NOUN
fnp-3806	3073	30	.	.	PUNCT
fnp-3806	3074	1	acta	acta	PROPN
fnp-3806	3074	2	neuropathol	neuropathol	PROPN
fnp-3806	3074	3	2011;122:577	2011;122:577	NUM
fnp-3806	3074	4	-	-	SYM
fnp-3806	3074	5	589	589	NUM
fnp-3806	3074	6	.	.	PUNCT
fnp-3806	3074	7	https://doi.org/10.1007/s00401-011-0871-6	https://doi.org/10.1007/s00401-011-0871-6	NUM
fnp-3806	3075	1	yamazaki	yamazaki	PROPN
fnp-3806	3075	2	y	y	PROPN
fnp-3806	3075	3	,	,	PUNCT
fnp-3806	3075	4	matsubara	matsubara	PROPN
fnp-3806	3075	5	t	t	PROPN
fnp-3806	3075	6	,	,	PUNCT
fnp-3806	3075	7	takahashi	takahashi	PROPN
fnp-3806	3075	8	t	t	PROPN
fnp-3806	3075	9	,	,	PUNCT
fnp-3806	3075	10	et	et	PROPN
fnp-3806	3075	11	al	al	PROPN
fnp-3806	3075	12	.	.	PROPN
fnp-3806	3076	1	granulovacuolar	granulovacuolar	PROPN
fnp-3806	3076	2	degenerations	degeneration	NOUN
fnp-3806	3076	3	appear	appear	VERB
fnp-3806	3076	4	in	in	ADP
fnp-3806	3076	5	relation	relation	NOUN
fnp-3806	3076	6	to	to	PART
fnp-3806	3076	7	hippocampal	hippocampal	VERB
fnp-3806	3076	8	phosphorylated	phosphorylate	VERB
fnp-3806	3076	9	tau	tau	PROPN
fnp-3806	3076	10	accumulation	accumulation	NOUN
fnp-3806	3076	11	in	in	ADP
fnp-3806	3076	12	various	various	ADJ
fnp-3806	3076	13	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3076	14	disorders	disorder	NOUN
fnp-3806	3076	15	.	.	PUNCT
fnp-3806	3077	1	plos	plos	PROPN
fnp-3806	3077	2	one	one	NUM
fnp-3806	3077	3	.	.	PUNCT
fnp-3806	3078	1	2011;6	2011;6	NUM
fnp-3806	3078	2	:	:	PUNCT
fnp-3806	3078	3	e26996	e26996	NOUN
fnp-3806	3078	4	.	.	PUNCT
fnp-3806	3079	1	https://doi.org/10.1371/journal.pone.0026996	https://doi.org/10.1371/journal.pone.0026996	NOUN
fnp-3806	3079	2	funk	funk	NOUN
fnp-3806	3079	3	ke	ke	PROPN
fnp-3806	3079	4	,	,	PUNCT
fnp-3806	3079	5	mrak	mrak	NOUN
fnp-3806	3079	6	re	re	PROPN
fnp-3806	3079	7	,	,	PUNCT
fnp-3806	3079	8	kuret	kuret	PROPN
fnp-3806	3079	9	j.	j.	PROPN
fnp-3806	3079	10	granulovacuolar	granulovacuolar	PROPN
fnp-3806	3079	11	degeneration	degeneration	NOUN
fnp-3806	3079	12	(	(	PUNCT
fnp-3806	3079	13	gvd	gvd	NOUN
fnp-3806	3079	14	)	)	PUNCT
fnp-3806	3079	15	bodies	body	NOUN
fnp-3806	3079	16	of	of	ADP
fnp-3806	3079	17	alzheimer	alzheimer	PROPN
fnp-3806	3079	18	’s	’s	PART
fnp-3806	3079	19	disease	disease	NOUN
fnp-3806	3079	20	(	(	PUNCT
fnp-3806	3079	21	ad	ad	NOUN
fnp-3806	3079	22	)	)	PUNCT
fnp-3806	3079	23	resemble	resemble	VERB
fnp-3806	3079	24	late	late	ADJ
fnp-3806	3079	25	-	-	PUNCT
fnp-3806	3079	26	stage	stage	NOUN
fnp-3806	3079	27	autophagic	autophagic	ADJ
fnp-3806	3079	28	organelles	organelle	NOUN
fnp-3806	3079	29	.	.	PUNCT
fnp-3806	3080	1	neuropathol	neuropathol	NOUN
fnp-3806	3080	2	appl	appl	PROPN
fnp-3806	3080	3	neurobiol	neurobiol	PROPN
fnp-3806	3080	4	2011;37:295	2011;37:295	PROPN
fnp-3806	3080	5	-	-	SYM
fnp-3806	3080	6	306	306	NUM
fnp-3806	3080	7	.	.	PUNCT
fnp-3806	3081	1	https://doi.org/10.1111/j.1365-2990.2010.01135.x	https://doi.org/10.1111/j.1365-2990.2010.01135.x	PROPN
fnp-3806	3081	2	köhler	köhler	PROPN
fnp-3806	3081	3	c.	c.	PROPN
fnp-3806	3081	4	granulovacuolar	granulovacuolar	PROPN
fnp-3806	3081	5	degeneration	degeneration	NOUN
fnp-3806	3081	6	:	:	PUNCT
fnp-3806	3081	7	a	a	DET
fnp-3806	3081	8	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3081	9	change	change	NOUN
fnp-3806	3081	10	that	that	PRON
fnp-3806	3081	11	accompanies	accompany	VERB
fnp-3806	3081	12	tau	tau	PROPN
fnp-3806	3081	13	pathology	pathology	PROPN
fnp-3806	3081	14	.	.	PUNCT
fnp-3806	3082	1	acta	acta	PROPN
fnp-3806	3082	2	neuropathologica	neuropathologica	PROPN
fnp-3806	3082	3	2016	2016	NUM
fnp-3806	3082	4	;	;	PUNCT
fnp-3806	3082	5	132	132	NUM
fnp-3806	3082	6	:	:	SYM
fnp-3806	3082	7	339	339	NUM
fnp-3806	3082	8	-	-	SYM
fnp-3806	3082	9	359	359	NUM
fnp-3806	3082	10	.	.	PUNCT
fnp-3806	3083	1	https://doi.org/10.1007/s00401-016-1562-0	https://doi.org/10.1007/s00401-016-1562-0	NUM
fnp-3806	3083	2	wiersma	wiersma	PROPN
fnp-3806	3083	3	vi	vi	PROPN
fnp-3806	3083	4	,	,	PUNCT
fnp-3806	3083	5	van	van	PROPN
fnp-3806	3083	6	ziel	ziel	PROPN
fnp-3806	3083	7	am	am	PROPN
fnp-3806	3083	8	,	,	PUNCT
fnp-3806	3083	9	vazquez‑sanchez	vazquez‑sanchez	PROPN
fnp-3806	3083	10	s	s	X
fnp-3806	3083	11	,	,	PUNCT
fnp-3806	3083	12	et	et	PROPN
fnp-3806	3083	13	al	al	PROPN
fnp-3806	3083	14	.	.	PROPN
fnp-3806	3084	1	granulovacuolar	granulovacuolar	ADJ
fnp-3806	3084	2	degeneration	degeneration	NOUN
fnp-3806	3084	3	bodies	body	NOUN
fnp-3806	3084	4	are	be	AUX
fnp-3806	3084	5	neuron‑selective	neuron‑selective	ADJ
fnp-3806	3084	6	lysosomal	lysosomal	ADJ
fnp-3806	3084	7	structures	structure	NOUN
fnp-3806	3084	8	induced	induce	VERB
fnp-3806	3084	9	by	by	ADP
fnp-3806	3084	10	intracellular	intracellular	ADJ
fnp-3806	3084	11	tau	tau	PROPN
fnp-3806	3084	12	pathology	pathology	NOUN
fnp-3806	3084	13	.	.	PUNCT
fnp-3806	3085	1	acta	acta	PROPN
fnp-3806	3085	2	neuropathologica	neuropathologica	PROPN
fnp-3806	3085	3	2019;138:943	2019;138:943	NUM
fnp-3806	3085	4	-	-	SYM
fnp-3806	3085	5	970	970	NUM
fnp-3806	3085	6	.	.	PUNCT
fnp-3806	3086	1	https://doi.org/10.1007/s00401-019-02046-4	https://doi.org/10.1007/s00401-019-02046-4	PROPN
fnp-3806	3086	2	hondius	hondius	PROPN
fnp-3806	3086	3	dc	dc	PROPN
fnp-3806	3086	4	,	,	PUNCT
fnp-3806	3086	5	koopmans	koopmans	PROPN
fnp-3806	3086	6	f	f	PROPN
fnp-3806	3086	7	,	,	PUNCT
fnp-3806	3086	8	leistner	leistner	NOUN
fnp-3806	3086	9	c	c	NOUN
fnp-3806	3086	10	,	,	PUNCT
fnp-3806	3086	11	et	et	PROPN
fnp-3806	3086	12	al	al	PROPN
fnp-3806	3086	13	.	.	PUNCT
fnp-3806	3087	1	the	the	DET
fnp-3806	3087	2	proteome	proteome	NOUN
fnp-3806	3087	3	of	of	ADP
fnp-3806	3087	4	granulovacuolar	granulovacuolar	ADJ
fnp-3806	3087	5	degeneration	degeneration	NOUN
fnp-3806	3087	6	and	and	CCONJ
fnp-3806	3087	7	neurofibrillary	neurofibrillary	ADJ
fnp-3806	3087	8	tangles	tangle	NOUN
fnp-3806	3087	9	in	in	ADP
fnp-3806	3087	10	alzheimer	alzheimer	PROPN
fnp-3806	3087	11	’s	’s	PART
fnp-3806	3087	12	disease	disease	NOUN
fnp-3806	3087	13	.	.	PUNCT
fnp-3806	3088	1	acta	acta	PROPN
fnp-3806	3088	2	neuropathol	neuropathol	PROPN
fnp-3806	3088	3	2021	2021	NUM
fnp-3806	3088	4	;	;	PUNCT
fnp-3806	3088	5	141	141	NUM
fnp-3806	3088	6	:	:	PUNCT
fnp-3806	3088	7	341	341	NUM
fnp-3806	3088	8	-	-	NUM
fnp-3806	3088	9	358	358	NUM
fnp-3806	3088	10	.	.	PUNCT
fnp-3806	3089	1	https://doi.org/10.1007/s00401-020-02261-4	https://doi.org/10.1007/s00401-020-02261-4	NUM
fnp-3806	3089	2	hunter	hunter	NOUN
fnp-3806	3089	3	s	s	PROPN
fnp-3806	3089	4	,	,	PUNCT
fnp-3806	3089	5	minett	minett	PROPN
fnp-3806	3089	6	t	t	PROPN
fnp-3806	3089	7	,	,	PUNCT
fnp-3806	3089	8	polvikoski	polvikoski	PROPN
fnp-3806	3089	9	t	t	PROPN
fnp-3806	3089	10	,	,	PUNCT
fnp-3806	3089	11	et	et	PROPN
fnp-3806	3089	12	al	al	PROPN
fnp-3806	3089	13	.	.	PROPN
fnp-3806	3089	14	re	re	VERB
fnp-3806	3089	15	-	-	VERB
fnp-3806	3089	16	examining	examine	VERB
fnp-3806	3089	17	tau	tau	NOUN
fnp-3806	3089	18	-	-	PUNCT
fnp-3806	3089	19	immunoreactive	immunoreactive	ADJ
fnp-3806	3089	20	pathology	pathology	NOUN
fnp-3806	3089	21	in	in	ADP
fnp-3806	3089	22	the	the	DET
fnp-3806	3089	23	population	population	NOUN
fnp-3806	3089	24	:	:	PUNCT
fnp-3806	3089	25	granulovacuolar	granulovacuolar	ADJ
fnp-3806	3089	26	degeneration	degeneration	NOUN
fnp-3806	3089	27	and	and	CCONJ
fnp-3806	3089	28	neurofibrillary	neurofibrillary	ADJ
fnp-3806	3089	29	tangles	tangle	NOUN
fnp-3806	3089	30	.	.	PUNCT
fnp-3806	3090	1	alzheimers	alzheimer	NOUN
fnp-3806	3090	2	res	re	VERB
fnp-3806	3090	3	ther	ther	ADV
fnp-3806	3090	4	2015;7:57	2015;7:57	NOUN
fnp-3806	3090	5	.	.	PUNCT
fnp-3806	3091	1	https://doi.org/10.1186/s13195-015-0141-2	https://doi.org/10.1186/s13195-015-0141-2	NUM
fnp-3806	3092	1	rudy	rudy	PROPN
fnp-3806	3092	2	cc	cc	PROPN
fnp-3806	3092	3	,	,	PUNCT
fnp-3806	3092	4	hunsberger	hunsberger	PROPN
fnp-3806	3092	5	hc	hc	PROPN
fnp-3806	3092	6	,	,	PUNCT
fnp-3806	3092	7	weitzner	weitzner	NOUN
fnp-3806	3092	8	ds	ds	NOUN
fnp-3806	3092	9	,	,	PUNCT
fnp-3806	3092	10	et	et	PROPN
fnp-3806	3092	11	al	al	PROPN
fnp-3806	3092	12	.	.	PUNCT
fnp-3806	3093	1	the	the	DET
fnp-3806	3093	2	role	role	NOUN
fnp-3806	3093	3	of	of	ADP
fnp-3806	3093	4	the	the	DET
fnp-3806	3093	5	tripartite	tripartite	ADJ
fnp-3806	3093	6	glutamatergic	glutamatergic	ADJ
fnp-3806	3093	7	synapse	synapse	NOUN
fnp-3806	3093	8	in	in	ADP
fnp-3806	3093	9	the	the	DET
fnp-3806	3093	10	pathophysiology	pathophysiology	NOUN
fnp-3806	3093	11	of	of	ADP
fnp-3806	3093	12	alzheimer	alzheimer	PROPN
fnp-3806	3093	13	's	's	PART
fnp-3806	3093	14	disease	disease	NOUN
fnp-3806	3093	15	.	.	PUNCT
fnp-3806	3094	1	aging	age	VERB
fnp-3806	3094	2	dis	dis	PROPN
fnp-3806	3094	3	2015;6:131	2015;6:131	PROPN
fnp-3806	3094	4	-	-	PROPN
fnp-3806	3094	5	148	148	NUM
fnp-3806	3094	6	.	.	PUNCT
fnp-3806	3095	1	https://doi.org/10.14336/ad.2014.0423	https://doi.org/10.14336/ad.2014.0423	PROPN
fnp-3806	3095	2	garwood	garwood	PROPN
fnp-3806	3095	3	cj	cj	PROPN
fnp-3806	3095	4	,	,	PUNCT
fnp-3806	3095	5	radcliffe	radcliffe	PROPN
fnp-3806	3095	6	le	le	PROPN
fnp-3806	3095	7	,	,	PUNCT
fnp-3806	3095	8	simpson	simpson	PROPN
fnp-3806	3095	9	je	je	PROPN
fnp-3806	3095	10	,	,	PUNCT
fnp-3806	3095	11	et	et	PROPN
fnp-3806	3095	12	al	al	PROPN
fnp-3806	3095	13	.	.	PROPN
fnp-3806	3095	14	review	review	PROPN
fnp-3806	3095	15	:	:	PUNCT
fnp-3806	3095	16	astrocytes	astrocyte	NOUN
fnp-3806	3095	17	in	in	ADP
fnp-3806	3095	18	alzheimer	alzheimer	PROPN
fnp-3806	3095	19	’s	’s	PART
fnp-3806	3095	20	disease	disease	NOUN
fnp-3806	3095	21	and	and	CCONJ
fnp-3806	3095	22	other	other	ADJ
fnp-3806	3095	23	age	age	NOUN
fnp-3806	3095	24	-	-	PUNCT
fnp-3806	3095	25	associated	associate	VERB
fnp-3806	3095	26	dementias	dementia	NOUN
fnp-3806	3095	27	:	:	PUNCT
fnp-3806	3095	28	the	the	DET
fnp-3806	3095	29	supporting	support	VERB
fnp-3806	3095	30	player	player	NOUN
fnp-3806	3095	31	with	with	ADP
fnp-3806	3095	32	a	a	DET
fnp-3806	3095	33	central	central	ADJ
fnp-3806	3095	34	role	role	NOUN
fnp-3806	3095	35	.	.	PUNCT
fnp-3806	3096	1	neuropathol	neuropathol	NOUN
fnp-3806	3096	2	appl	appl	PROPN
fnp-3806	3096	3	neurobiol	neurobiol	PROPN
fnp-3806	3096	4	2017	2017	NUM
fnp-3806	3096	5	;	;	PUNCT
fnp-3806	3096	6	43:281	43:281	NUM
fnp-3806	3096	7	-	-	SYM
fnp-3806	3096	8	298	298	NUM
fnp-3806	3096	9	.	.	PUNCT
fnp-3806	3097	1	https://doi.org/10.1111/nan.12338	https://doi.org/10.1111/nan.12338	PROPN
fnp-3806	3097	2	ferrer	ferrer	PROPN
fnp-3806	3097	3	i.	i.	PROPN
fnp-3806	3097	4	diversity	diversity	NOUN
fnp-3806	3097	5	of	of	ADP
fnp-3806	3097	6	astroglial	astroglial	ADJ
fnp-3806	3097	7	responses	response	NOUN
fnp-3806	3097	8	across	across	ADP
fnp-3806	3097	9	human	human	ADJ
fnp-3806	3097	10	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3097	11	disorders	disorder	NOUN
fnp-3806	3097	12	and	and	CCONJ
fnp-3806	3097	13	brain	brain	NOUN
fnp-3806	3097	14	aging	aging	NOUN
fnp-3806	3097	15	.	.	PUNCT
fnp-3806	3098	1	brain	brain	NOUN
fnp-3806	3098	2	pathol	pathol	NOUN
fnp-3806	3098	3	2017;27:645	2017;27:645	NOUN
fnp-3806	3098	4	-	-	SYM
fnp-3806	3098	5	674	674	NUM
fnp-3806	3098	6	.	.	PUNCT
fnp-3806	3099	1	https://doi.org/10.1111/bpa.12538	https://doi.org/10.1111/bpa.12538	VERB
fnp-3806	3099	2	verkhratsky	verkhratsky	ADP
fnp-3806	3099	3	a	a	DET
fnp-3806	3099	4	,	,	PUNCT
fnp-3806	3099	5	zorec	zorec	NOUN
fnp-3806	3099	6	r	r	NOUN
fnp-3806	3099	7	,	,	PUNCT
fnp-3806	3099	8	rodriguez	rodriguez	NOUN
fnp-3806	3099	9	-	-	PUNCT
fnp-3806	3099	10	arellano	arellano	PROPN
fnp-3806	3099	11	jj	jj	PROPN
fnp-3806	3099	12	,	,	PUNCT
fnp-3806	3099	13	et	et	PROPN
fnp-3806	3099	14	al	al	PROPN
fnp-3806	3099	15	.	.	PROPN
fnp-3806	3099	16	neuroglia	neuroglia	PROPN
fnp-3806	3099	17	in	in	ADP
fnp-3806	3099	18	ageing	age	VERB
fnp-3806	3099	19	.	.	PUNCT
fnp-3806	3100	1	adv	adv	PROPN
fnp-3806	3100	2	exp	exp	NOUN
fnp-3806	3100	3	med	med	ADJ
fnp-3806	3100	4	biol	biol	NOUN
fnp-3806	3100	5	2019;1175:181	2019;1175:181	PROPN
fnp-3806	3100	6	-	-	SYM
fnp-3806	3100	7	197	197	NUM
fnp-3806	3100	8	.	.	PUNCT
fnp-3806	3101	1	https://doi.org/10.1007/978-981-13-9913-8_8	https://doi.org/10.1007/978-981-13-9913-8_8	PROPN
fnp-3806	3101	2	price	price	NOUN
fnp-3806	3101	3	br	br	PROPN
fnp-3806	3101	4	,	,	PUNCT
fnp-3806	3101	5	johnson	johnson	PROPN
fnp-3806	3101	6	la	la	PROPN
fnp-3806	3101	7	,	,	PUNCT
fnp-3806	3101	8	norris	norris	PROPN
fnp-3806	3101	9	cm	cm	PROPN
fnp-3806	3101	10	.	.	PUNCT
fnp-3806	3102	1	reactive	reactive	ADJ
fnp-3806	3102	2	astrocytes	astrocyte	NOUN
fnp-3806	3102	3	:	:	PUNCT
fnp-3806	3102	4	the	the	DET
fnp-3806	3102	5	nexus	nexus	NOUN
fnp-3806	3102	6	of	of	ADP
fnp-3806	3102	7	pathological	pathological	ADJ
fnp-3806	3102	8	and	and	CCONJ
fnp-3806	3102	9	clinical	clinical	ADJ
fnp-3806	3102	10	hallmarks	hallmark	NOUN
fnp-3806	3102	11	of	of	ADP
fnp-3806	3102	12	alzheimer	alzheimer	PROPN
fnp-3806	3102	13	's	's	PART
fnp-3806	3102	14	disease	disease	NOUN
fnp-3806	3102	15	.	.	PUNCT
fnp-3806	3103	1	ageing	age	VERB
fnp-3806	3103	2	res	re	NOUN
fnp-3806	3103	3	rev	rev	X
fnp-3806	3103	4	2021;68:101335	2021;68:101335	PROPN
fnp-3806	3103	5	.	.	PUNCT
fnp-3806	3104	1	https://doi.org/10.1016/j.arr.2021.101335	https://doi.org/10.1016/j.arr.2021.101335	PROPN
fnp-3806	3104	2	phillips	phillips	PROPN
fnp-3806	3104	3	ec	ec	PROPN
fnp-3806	3104	4	,	,	PUNCT
fnp-3806	3104	5	croft	croft	PROPN
fnp-3806	3104	6	cl	cl	PROPN
fnp-3806	3104	7	,	,	PUNCT
fnp-3806	3104	8	kurbatskaya	kurbatskaya	PROPN
fnp-3806	3105	1	k	k	PROPN
fnp-3806	3105	2	,	,	PUNCT
fnp-3806	3105	3	et	et	PROPN
fnp-3806	3105	4	al	al	PROPN
fnp-3806	3105	5	.	.	PROPN
fnp-3806	3105	6	astrocytes	astrocyte	NOUN
fnp-3806	3105	7	and	and	CCONJ
fnp-3806	3105	8	neuroinflammation	neuroinflammation	NOUN
fnp-3806	3105	9	in	in	ADP
fnp-3806	3105	10	alzheimer	alzheimer	PROPN
fnp-3806	3105	11	's	's	PART
fnp-3806	3105	12	disease	disease	NOUN
fnp-3806	3105	13	.	.	PUNCT
fnp-3806	3106	1	biochem	biochem	PROPN
fnp-3806	3106	2	soc	soc	PROPN
fnp-3806	3106	3	trans	trans	PROPN
fnp-3806	3106	4	2014	2014	NUM
fnp-3806	3106	5	;	;	PUNCT
fnp-3806	3106	6	42	42	NUM
fnp-3806	3106	7	:	:	SYM
fnp-3806	3106	8	1321	1321	NUM
fnp-3806	3106	9	-	-	SYM
fnp-3806	3106	10	1325	1325	NUM
fnp-3806	3106	11	.	.	PUNCT
fnp-3806	3107	1	https://doi.org/10.1042/bst20140155	https://doi.org/10.1042/bst20140155	PROPN
fnp-3806	3107	2	heneka	heneka	PROPN
fnp-3806	3107	3	mt	mt	PROPN
fnp-3806	3107	4	,	,	PUNCT
fnp-3806	3107	5	carson	carson	PROPN
fnp-3806	3107	6	mj	mj	PROPN
fnp-3806	3107	7	,	,	PUNCT
fnp-3806	3107	8	el	el	PROPN
fnp-3806	3107	9	khoury	khoury	PROPN
fnp-3806	3107	10	j	j	PROPN
fnp-3806	3107	11	,	,	PUNCT
fnp-3806	3107	12	et	et	PROPN
fnp-3806	3107	13	al	al	PROPN
fnp-3806	3107	14	.	.	PUNCT
fnp-3806	3108	1	o	o	PROPN
fnp-3806	3108	2	,	,	PUNCT
fnp-3806	3108	3	neuroinflammation	neuroinflammation	NOUN
fnp-3806	3108	4	in	in	ADP
fnp-3806	3108	5	alzheimer	alzheimer	PROPN
fnp-3806	3108	6	's	's	PART
fnp-3806	3108	7	disease	disease	NOUN
fnp-3806	3108	8	.	.	PUNCT
fnp-3806	3109	1	lancet	lancet	PROPN
fnp-3806	3109	2	neurol	neurol	PROPN
fnp-3806	3109	3	2015;14	2015;14	NUM
fnp-3806	3109	4	:	:	PUNCT
fnp-3806	3109	5	388	388	NUM
fnp-3806	3109	6	-	-	SYM
fnp-3806	3109	7	405	405	NUM
fnp-3806	3109	8	.	.	PUNCT
fnp-3806	3110	1	https://doi.org/10.1016/s1474-4422(15)70016-5	https://doi.org/10.1016/s1474-4422(15)70016-5	PROPN
fnp-3806	3110	2	de	de	PROPN
fnp-3806	3110	3	strooper	strooper	PROPN
fnp-3806	3110	4	bd	bd	PROPN
fnp-3806	3110	5	,	,	PUNCT
fnp-3806	3110	6	karran	karran	PROPN
fnp-3806	3110	7	e.	e.	PROPN
fnp-3806	3111	1	the	the	DET
fnp-3806	3111	2	cellular	cellular	ADJ
fnp-3806	3111	3	phase	phase	NOUN
fnp-3806	3111	4	of	of	ADP
fnp-3806	3111	5	alzheimer	alzheimer	PROPN
fnp-3806	3111	6	’s	’s	PART
fnp-3806	3111	7	disease	disease	NOUN
fnp-3806	3111	8	.	.	PUNCT
fnp-3806	3112	1	cell	cell	NOUN
fnp-3806	3112	2	2016;164	2016;164	NOUN
fnp-3806	3112	3	:	:	PUNCT
fnp-3806	3112	4	603	603	NUM
fnp-3806	3112	5	-	-	SYM
fnp-3806	3112	6	615	615	NUM
fnp-3806	3112	7	.	.	PUNCT
fnp-3806	3113	1	https://doi.org/10.1016/j.cell.2015.12.056	https://doi.org/10.1016/j.cell.2015.12.056	PROPN
fnp-3806	3113	2	liddelow	liddelow	PROPN
fnp-3806	3113	3	sa	sa	PROPN
fnp-3806	3113	4	,	,	PUNCT
fnp-3806	3113	5	guttenplan	guttenplan	PROPN
fnp-3806	3113	6	ka	ka	PROPN
fnp-3806	3113	7	,	,	PUNCT
fnp-3806	3113	8	clarke	clarke	PROPN
fnp-3806	3113	9	le	le	PROPN
fnp-3806	3113	10	,	,	PUNCT
fnp-3806	3113	11	et	et	PROPN
fnp-3806	3113	12	al	al	PROPN
fnp-3806	3113	13	.	.	PROPN
fnp-3806	3114	1	neurotoxic	neurotoxic	ADJ
fnp-3806	3114	2	reactive	reactive	ADJ
fnp-3806	3114	3	astrocytes	astrocyte	NOUN
fnp-3806	3114	4	are	be	AUX
fnp-3806	3114	5	induced	induce	VERB
fnp-3806	3114	6	by	by	ADP
fnp-3806	3114	7	activated	activated	ADJ
fnp-3806	3114	8	microglia	microglia	NOUN
fnp-3806	3114	9	.	.	PUNCT
fnp-3806	3115	1	nature	nature	NOUN
fnp-3806	3115	2	2017;541	2017;541	NUM
fnp-3806	3115	3	:	:	PUNCT
fnp-3806	3115	4	481	481	NUM
fnp-3806	3115	5	-	-	SYM
fnp-3806	3115	6	487	487	NUM
fnp-3806	3115	7	.	.	PUNCT
fnp-3806	3116	1	https://doi.org/10.1038/nature21029	https://doi.org/10.1038/nature21029	NOUN
fnp-3806	3116	2	kaur	kaur	PROPN
fnp-3806	3116	3	d	d	PROPN
fnp-3806	3116	4	,	,	PUNCT
fnp-3806	3116	5	sharma	sharma	PROPN
fnp-3806	3116	6	v	v	PROPN
fnp-3806	3116	7	,	,	PUNCT
fnp-3806	3116	8	deshmukh	deshmukh	PROPN
fnp-3806	3116	9	r.	r.	PROPN
fnp-3806	3116	10	activation	activation	NOUN
fnp-3806	3116	11	of	of	ADP
fnp-3806	3116	12	microglia	microglia	NOUN
fnp-3806	3116	13	and	and	CCONJ
fnp-3806	3116	14	astrocytes	astrocyte	NOUN
fnp-3806	3116	15	:	:	PUNCT
fnp-3806	3116	16	a	a	DET
fnp-3806	3116	17	roadway	roadway	NOUN
fnp-3806	3116	18	to	to	ADP
fnp-3806	3116	19	neuroinflammation	neuroinflammation	NOUN
fnp-3806	3116	20	and	and	CCONJ
fnp-3806	3116	21	alzheimer	alzheimer	PROPN
fnp-3806	3116	22	's	's	PART
fnp-3806	3116	23	disease	disease	NOUN
fnp-3806	3116	24	.	.	PUNCT
fnp-3806	3117	1	inflammopharmacology	inflammopharmacology	NOUN
fnp-3806	3117	2	2019;27:663	2019;27:663	PROPN
fnp-3806	3117	3	-	-	SYM
fnp-3806	3117	4	677	677	NUM
fnp-3806	3117	5	.	.	PUNCT
fnp-3806	3118	1	https://doi.org/10.1007/s10787-019-00580-x	https://doi.org/10.1007/s10787-019-00580-x	PROPN
fnp-3806	3118	2	verkhratsky	verkhratsky	VERB
fnp-3806	3118	3	a	a	DET
fnp-3806	3118	4	,	,	PUNCT
fnp-3806	3118	5	nedergaard	nedergaard	ADJ
fnp-3806	3118	6	m.	m.	NOUN
fnp-3806	3118	7	physiology	physiology	NOUN
fnp-3806	3118	8	of	of	ADP
fnp-3806	3118	9	astroglia	astroglia	PROPN
fnp-3806	3118	10	.	.	PUNCT
fnp-3806	3119	1	physiol	physiol	PROPN
fnp-3806	3119	2	rev	rev	VERB
fnp-3806	3119	3	2018;98:239	2018;98:239	PROPN
fnp-3806	3119	4	-	-	SYM
fnp-3806	3119	5	389	389	NUM
fnp-3806	3119	6	.	.	PUNCT
fnp-3806	3120	1	https://doi.org/10.1152/physrev.00042.2016	https://doi.org/10.1152/physrev.00042.2016	PROPN
fnp-3806	3120	2	verkhratsky	verkhratsky	VERB
fnp-3806	3120	3	a	a	DET
fnp-3806	3120	4	,	,	PUNCT
fnp-3806	3120	5	parpura	parpura	NOUN
fnp-3806	3120	6	v	v	NOUN
fnp-3806	3120	7	,	,	PUNCT
fnp-3806	3120	8	li	li	PROPN
fnp-3806	3120	9	b	b	PROPN
fnp-3806	3120	10	,	,	PUNCT
fnp-3806	3120	11	et	et	PROPN
fnp-3806	3120	12	al	al	PROPN
fnp-3806	3120	13	.	.	PROPN
fnp-3806	3120	14	astrocytes	astrocyte	VERB
fnp-3806	3120	15	:	:	PUNCT
fnp-3806	3120	16	the	the	DET
fnp-3806	3120	17	housekeepers	housekeeper	NOUN
fnp-3806	3120	18	and	and	CCONJ
fnp-3806	3120	19	guardians	guardian	NOUN
fnp-3806	3120	20	of	of	ADP
fnp-3806	3120	21	the	the	DET
fnp-3806	3120	22	cns	cns	NOUN
fnp-3806	3120	23	.	.	PUNCT
fnp-3806	3121	1	adv	adv	PROPN
fnp-3806	3121	2	neurobiol	neurobiol	PROPN
fnp-3806	3121	3	2021;26:21	2021;26:21	NUM
fnp-3806	3121	4	-	-	SYM
fnp-3806	3121	5	53	53	NUM
fnp-3806	3121	6	.	.	PUNCT
fnp-3806	3121	7	https://doi.org/10.1007/978-3-030-77375-5_2	https://doi.org/10.1007/978-3-030-77375-5_2	PROPN
fnp-3806	3121	8	cotrina	cotrina	PROPN
fnp-3806	3121	9	ml	ml	AUX
fnp-3806	3121	10	,	,	PUNCT
fnp-3806	3121	11	nedergaard	nedergaard	ADJ
fnp-3806	3121	12	m.	m.	NOUN
fnp-3806	3121	13	astrocytes	astrocyte	NOUN
fnp-3806	3121	14	in	in	ADP
fnp-3806	3121	15	the	the	DET
fnp-3806	3121	16	aging	age	VERB
fnp-3806	3121	17	brain	brain	NOUN
fnp-3806	3121	18	.	.	PUNCT
fnp-3806	3122	1	j	j	PROPN
fnp-3806	3122	2	neurosci	neurosci	PROPN
fnp-3806	3122	3	res	re	VERB
fnp-3806	3122	4	2002;67:1	2002;67:1	NUM
fnp-3806	3122	5	-	-	SYM
fnp-3806	3122	6	10	10	NUM
fnp-3806	3122	7	.	.	PUNCT
fnp-3806	3123	1	https://doi.org/10.1002/jnr.10121	https://doi.org/10.1002/jnr.10121	VERB
fnp-3806	3123	2	porchet	porchet	NOUN
fnp-3806	3123	3	r	r	NOUN
fnp-3806	3123	4	,	,	PUNCT
fnp-3806	3123	5	probst	probst	NOUN
fnp-3806	3123	6	a	a	PRON
fnp-3806	3123	7	,	,	PUNCT
fnp-3806	3123	8	bouras	boura	NOUN
fnp-3806	3123	9	c	c	NOUN
fnp-3806	3123	10	,	,	PUNCT
fnp-3806	3123	11	et	et	PROPN
fnp-3806	3123	12	al	al	PROPN
fnp-3806	3123	13	.	.	PUNCT
fnp-3806	3123	14	analysis	analysis	NOUN
fnp-3806	3123	15	of	of	ADP
fnp-3806	3123	16	glial	glial	ADJ
fnp-3806	3123	17	acidic	acidic	ADJ
fnp-3806	3123	18	fibrillary	fibrillary	ADJ
fnp-3806	3123	19	protein	protein	NOUN
fnp-3806	3123	20	in	in	ADP
fnp-3806	3123	21	the	the	DET
fnp-3806	3123	22	human	human	ADJ
fnp-3806	3123	23	entorhinal	entorhinal	ADJ
fnp-3806	3123	24	cortex	cortex	NOUN
fnp-3806	3123	25	during	during	ADP
fnp-3806	3123	26	aging	age	VERB
fnp-3806	3123	27	and	and	CCONJ
fnp-3806	3123	28	in	in	ADP
fnp-3806	3123	29	alzheimer	alzheimer	PROPN
fnp-3806	3123	30	's	's	PART
fnp-3806	3123	31	disease	disease	NOUN
fnp-3806	3123	32	.	.	PUNCT
fnp-3806	3124	1	proteomics	proteomic	NOUN
fnp-3806	3124	2	2003;3	2003;3	NUM
fnp-3806	3124	3	:	:	PUNCT
fnp-3806	3124	4	1476	1476	NUM
fnp-3806	3124	5	-	-	SYM
fnp-3806	3124	6	1485	1485	NUM
fnp-3806	3124	7	.	.	PUNCT
fnp-3806	3125	1	https://doi.org/10.1002/pmic.200300456	https://doi.org/10.1002/pmic.200300456	PROPN
fnp-3806	3125	2	lynch	lynch	PROPN
fnp-3806	3125	3	am	am	PROPN
fnp-3806	3125	4	,	,	PUNCT
fnp-3806	3125	5	murphy	murphy	PROPN
fnp-3806	3125	6	kj	kj	PROPN
fnp-3806	3125	7	,	,	PUNCT
fnp-3806	3125	8	deighan	deighan	PROPN
fnp-3806	3125	9	bf	bf	PROPN
fnp-3806	3125	10	,	,	PUNCT
fnp-3806	3125	11	et	et	PROPN
fnp-3806	3125	12	al	al	PROPN
fnp-3806	3125	13	.	.	PUNCT
fnp-3806	3126	1	the	the	DET
fnp-3806	3126	2	impact	impact	NOUN
fnp-3806	3126	3	of	of	ADP
fnp-3806	3126	4	glial	glial	ADJ
fnp-3806	3126	5	activation	activation	NOUN
fnp-3806	3126	6	in	in	ADP
fnp-3806	3126	7	the	the	DET
fnp-3806	3126	8	aging	age	VERB
fnp-3806	3126	9	brain	brain	NOUN
fnp-3806	3126	10	.	.	PUNCT
fnp-3806	3127	1	aging	age	VERB
fnp-3806	3127	2	dis	dis	PROPN
fnp-3806	3127	3	2010;1	2010;1	PROPN
fnp-3806	3127	4	:	:	PUNCT
fnp-3806	3127	5	262	262	NUM
fnp-3806	3127	6	-	-	SYM
fnp-3806	3127	7	278	278	NUM
fnp-3806	3127	8	.	.	PUNCT
fnp-3806	3128	1	pmid	pmid	NOUN
fnp-3806	3128	2	:	:	PUNCT
fnp-3806	3128	3	22396865	22396865	NUM
fnp-3806	3128	4	.	.	PUNCT
fnp-3806	3129	1	salminen	salminen	PROPN
fnp-3806	3129	2	a	a	NOUN
fnp-3806	3129	3	,	,	PUNCT
fnp-3806	3129	4	ojala	ojala	PROPN
fnp-3806	3129	5	j	j	PROPN
fnp-3806	3129	6	,	,	PUNCT
fnp-3806	3129	7	kaarniranta	kaarniranta	PROPN
fnp-3806	3129	8	k	k	PROPN
fnp-3806	3129	9	,	,	PUNCT
fnp-3806	3129	10	et	et	PROPN
fnp-3806	3129	11	al	al	PROPN
fnp-3806	3129	12	.	.	PROPN
fnp-3806	3129	13	astrocytes	astrocyte	NOUN
fnp-3806	3129	14	in	in	ADP
fnp-3806	3129	15	the	the	DET
fnp-3806	3129	16	aging	age	VERB
fnp-3806	3129	17	brain	brain	NOUN
fnp-3806	3129	18	express	express	ADJ
fnp-3806	3129	19	characteristics	characteristic	NOUN
fnp-3806	3129	20	of	of	ADP
fnp-3806	3129	21	senescence	senescence	NOUN
fnp-3806	3129	22	-	-	PUNCT
fnp-3806	3129	23	associated	associate	VERB
fnp-3806	3129	24	secretory	secretory	ADJ
fnp-3806	3129	25	phenotype	phenotype	NOUN
fnp-3806	3129	26	.	.	PUNCT
fnp-3806	3130	1	eur	eur	PROPN
fnp-3806	3130	2	j	j	PROPN
fnp-3806	3130	3	neurosci	neurosci	PROPN
fnp-3806	3130	4	2011;34	2011;34	NUM
fnp-3806	3130	5	:	:	PUNCT
fnp-3806	3130	6	3	3	NUM
fnp-3806	3130	7	-	-	SYM
fnp-3806	3130	8	11	11	NUM
fnp-3806	3130	9	.	.	PUNCT
fnp-3806	3131	1	https://doi.org/10.1111/j.1460-9568.2011.07738.x	https://doi.org/10.1111/j.1460-9568.2011.07738.x	PROPN
fnp-3806	3131	2	farrall	farrall	PROPN
fnp-3806	3131	3	aj	aj	PROPN
fnp-3806	3131	4	,	,	PUNCT
fnp-3806	3131	5	wardlaw	wardlaw	PROPN
fnp-3806	3131	6	jm	jm	PROPN
fnp-3806	3131	7	.	.	PROPN
fnp-3806	3131	8	blood	blood	NOUN
fnp-3806	3131	9	-	-	PUNCT
fnp-3806	3131	10	brain	brain	NOUN
fnp-3806	3131	11	barrier	barrier	NOUN
fnp-3806	3131	12	:	:	PUNCT
fnp-3806	3131	13	ageing	age	VERB
fnp-3806	3131	14	and	and	CCONJ
fnp-3806	3131	15	microvascular	microvascular	ADJ
fnp-3806	3131	16	disease	disease	NOUN
fnp-3806	3131	17	--	--	PUNCT
fnp-3806	3131	18	systematic	systematic	ADJ
fnp-3806	3131	19	review	review	NOUN
fnp-3806	3131	20	and	and	CCONJ
fnp-3806	3131	21	meta	meta	ADJ
fnp-3806	3131	22	-	-	PUNCT
fnp-3806	3131	23	analysis	analysis	NOUN
fnp-3806	3131	24	.	.	PUNCT
fnp-3806	3132	1	neurobiol	neurobiol	NOUN
fnp-3806	3132	2	aging	age	VERB
fnp-3806	3132	3	2009;30:337	2009;30:337	PROPN
fnp-3806	3132	4	-	-	PUNCT
fnp-3806	3132	5	352	352	NUM
fnp-3806	3132	6	.	.	PUNCT
fnp-3806	3133	1	https://doi.org/10.1016/j.neurobiolaging	https://doi.org/10.1016/j.neurobiolage	VERB
fnp-3806	3133	2	2007.07.015	2007.07.015	PROPN
fnp-3806	3133	3	.	.	PUNCT
fnp-3806	3134	1	popescu	popescu	PROPN
fnp-3806	3134	2	bo	bo	PROPN
fnp-3806	3134	3	,	,	PUNCT
fnp-3806	3134	4	toescu	toescu	PROPN
fnp-3806	3134	5	ec	ec	PROPN
fnp-3806	3134	6	,	,	PUNCT
fnp-3806	3134	7	popescu	popescu	PROPN
fnp-3806	3134	8	lm	lm	PROPN
fnp-3806	3134	9	,	,	PUNCT
fnp-3806	3134	10	et	et	PROPN
fnp-3806	3134	11	al	al	PROPN
fnp-3806	3134	12	.	.	PUNCT
fnp-3806	3134	13	blood	blood	NOUN
fnp-3806	3134	14	-	-	PUNCT
fnp-3806	3134	15	brain	brain	NOUN
fnp-3806	3134	16	barrier	barrier	NOUN
fnp-3806	3134	17	alterations	alteration	NOUN
fnp-3806	3134	18	in	in	ADP
fnp-3806	3134	19	ageing	ageing	NOUN
fnp-3806	3134	20	and	and	CCONJ
fnp-3806	3134	21	dementia	dementia	NOUN
fnp-3806	3134	22	.	.	PUNCT
fnp-3806	3135	1	j	j	PROPN
fnp-3806	3135	2	neurol	neurol	PROPN
fnp-3806	3135	3	sci	sci	PROPN
fnp-3806	3135	4	2009;283	2009;283	NUM
fnp-3806	3135	5	:	:	PUNCT
fnp-3806	3135	6	99	99	NUM
fnp-3806	3135	7	-	-	SYM
fnp-3806	3135	8	106	106	NUM
fnp-3806	3135	9	.	.	PUNCT
fnp-3806	3136	1	https://doi.org/10.1016/j.jns.2009.02.321	https://doi.org/10.1016/j.jns.2009.02.321	PROPN
fnp-3806	3136	2	silverberg	silverberg	PROPN
fnp-3806	3136	3	gd	gd	PROPN
fnp-3806	3136	4	,	,	PUNCT
fnp-3806	3136	5	messier	messy	ADJ
fnp-3806	3136	6	aa	aa	PROPN
fnp-3806	3136	7	,	,	PUNCT
fnp-3806	3136	8	miller	miller	PROPN
fnp-3806	3136	9	mc	mc	PROPN
fnp-3806	3136	10	,	,	PUNCT
fnp-3806	3136	11	et	et	PROPN
fnp-3806	3136	12	al	al	PROPN
fnp-3806	3136	13	.	.	PUNCT
fnp-3806	3137	1	amyloid	amyloid	PROPN
fnp-3806	3137	2	efflux	efflux	VERB
fnp-3806	3137	3	transporter	transporter	NOUN
fnp-3806	3137	4	expression	expression	NOUN
fnp-3806	3137	5	at	at	ADP
fnp-3806	3137	6	the	the	DET
fnp-3806	3137	7	blood	blood	NOUN
fnp-3806	3137	8	-	-	PUNCT
fnp-3806	3137	9	brain	brain	NOUN
fnp-3806	3137	10	barrier	barrier	NOUN
fnp-3806	3137	11	declines	decline	VERB
fnp-3806	3137	12	in	in	ADP
fnp-3806	3137	13	normal	normal	ADJ
fnp-3806	3137	14	aging	aging	NOUN
fnp-3806	3137	15	.	.	PUNCT
fnp-3806	3138	1	j	j	PROPN
fnp-3806	3138	2	neuropathol	neuropathol	PROPN
fnp-3806	3138	3	exp	exp	PROPN
fnp-3806	3138	4	neurol	neurol	PROPN
fnp-3806	3138	5	2010;69	2010;69	NUM
fnp-3806	3138	6	:	:	PUNCT
fnp-3806	3138	7	1034	1034	NUM
fnp-3806	3138	8	-	-	SYM
fnp-3806	3138	9	1043	1043	NUM
fnp-3806	3138	10	.	.	PUNCT
fnp-3806	3139	1	https://doi.org/10.1097/nen.0b013e3181f46e25	https://doi.org/10.1097/nen.0b013e3181f46e25	PROPN
fnp-3806	3139	2	silverberg	silverberg	PROPN
fnp-3806	3139	3	gd	gd	PROPN
fnp-3806	3139	4	,	,	PUNCT
fnp-3806	3139	5	miller	miller	PROPN
fnp-3806	3139	6	mc	mc	PROPN
fnp-3806	3139	7	,	,	PUNCT
fnp-3806	3139	8	messier	messy	ADJ
fnp-3806	3139	9	aa	aa	PROPN
fnp-3806	3139	10	,	,	PUNCT
fnp-3806	3139	11	et	et	PROPN
fnp-3806	3139	12	al	al	PROPN
fnp-3806	3139	13	.	.	PUNCT
fnp-3806	3139	14	amyloid	amyloid	NOUN
fnp-3806	3139	15	deposition	deposition	NOUN
fnp-3806	3139	16	and	and	CCONJ
fnp-3806	3139	17	influx	influx	VERB
fnp-3806	3139	18	transporter	transporter	NOUN
fnp-3806	3139	19	expression	expression	NOUN
fnp-3806	3139	20	at	at	ADP
fnp-3806	3139	21	the	the	DET
fnp-3806	3139	22	blood	blood	NOUN
fnp-3806	3139	23	-	-	PUNCT
fnp-3806	3139	24	brain	brain	NOUN
fnp-3806	3139	25	barrier	barrier	NOUN
fnp-3806	3139	26	increase	increase	NOUN
fnp-3806	3139	27	in	in	ADP
fnp-3806	3139	28	normal	normal	ADJ
fnp-3806	3139	29	aging	aging	NOUN
fnp-3806	3139	30	.	.	PUNCT
fnp-3806	3140	1	j	j	PROPN
fnp-3806	3140	2	neuropathol	neuropathol	PROPN
fnp-3806	3140	3	exp	exp	PROPN
fnp-3806	3140	4	neurol	neurol	NOUN
fnp-3806	3140	5	2010b;69	2010b;69	NUM
fnp-3806	3140	6	:	:	PUNCT
fnp-3806	3140	7	98	98	NUM
fnp-3806	3140	8	-	-	SYM
fnp-3806	3140	9	108	108	NUM
fnp-3806	3140	10	.	.	PUNCT
fnp-3806	3141	1	https://doi.org/10.1097/nen.0b013e3181c8ad2f	https://doi.org/10.1097/nen.0b013e3181c8ad2f	NOUN
fnp-3806	3141	2	pérez	pérez	NOUN
fnp-3806	3141	3	e	e	PROPN
fnp-3806	3141	4	,	,	PUNCT
fnp-3806	3141	5	barrachina	barrachina	PROPN
fnp-3806	3141	6	m	m	PROPN
fnp-3806	3141	7	,	,	PUNCT
fnp-3806	3141	8	rodriguez	rodriguez	PROPN
fnp-3806	3141	9	a	a	X
fnp-3806	3141	10	,	,	PUNCT
fnp-3806	3141	11	et	et	PROPN
fnp-3806	3141	12	al	al	PROPN
fnp-3806	3141	13	.	.	PROPN
fnp-3806	3141	14	aquaporin	aquaporin	PROPN
fnp-3806	3141	15	expression	expression	NOUN
fnp-3806	3141	16	in	in	ADP
fnp-3806	3141	17	the	the	DET
fnp-3806	3141	18	cerebral	cerebral	ADJ
fnp-3806	3141	19	cortex	cortex	NOUN
fnp-3806	3141	20	is	be	AUX
fnp-3806	3141	21	increased	increase	VERB
fnp-3806	3141	22	at	at	ADP
fnp-3806	3141	23	early	early	ADJ
fnp-3806	3141	24	stages	stage	NOUN
fnp-3806	3141	25	of	of	ADP
fnp-3806	3141	26	alzheimer	alzheimer	NOUN
fnp-3806	3141	27	's	's	PART
fnp-3806	3141	28	disease	disease	NOUN
fnp-3806	3141	29	.	.	PUNCT
fnp-3806	3142	1	brain	brain	NOUN
fnp-3806	3142	2	res	re	NOUN
fnp-3806	3142	3	2007;1128:164	2007;1128:164	NOUN
fnp-3806	3142	4	-	-	SYM
fnp-3806	3142	5	174	174	NUM
fnp-3806	3142	6	.	.	PUNCT
fnp-3806	3143	1	https://doi.org/10.1016/j.brainres	https://doi.org/10.1016/j.brainre	NOUN
fnp-3806	3143	2	2006.09.109	2006.09.109	VERB
fnp-3806	3143	3	.	.	PUNCT
fnp-3806	3144	1	zeppenfeld	zeppenfeld	PROPN
fnp-3806	3144	2	dm	dm	PROPN
fnp-3806	3144	3	,	,	PUNCT
fnp-3806	3144	4	simon	simon	PROPN
fnp-3806	3144	5	m	m	PROPN
fnp-3806	3144	6	,	,	PUNCT
fnp-3806	3144	7	haswell	haswell	PROPN
fnp-3806	3144	8	jd	jd	PROPN
fnp-3806	3144	9	,	,	PUNCT
fnp-3806	3144	10	et	et	PROPN
fnp-3806	3144	11	al	al	PROPN
fnp-3806	3144	12	.	.	PROPN
fnp-3806	3144	13	association	association	PROPN
fnp-3806	3144	14	of	of	ADP
fnp-3806	3144	15	perivascular	perivascular	ADJ
fnp-3806	3144	16	localization	localization	NOUN
fnp-3806	3144	17	of	of	ADP
fnp-3806	3144	18	aquaporin-4	aquaporin-4	PROPN
fnp-3806	3144	19	with	with	ADP
fnp-3806	3144	20	cognition	cognition	NOUN
fnp-3806	3144	21	and	and	CCONJ
fnp-3806	3144	22	alzheimer	alzheimer	NOUN
fnp-3806	3144	23	disease	disease	NOUN
fnp-3806	3144	24	in	in	ADP
fnp-3806	3144	25	aging	age	VERB
fnp-3806	3144	26	brains	brain	NOUN
fnp-3806	3144	27	.	.	PUNCT
fnp-3806	3145	1	jama	jama	PROPN
fnp-3806	3145	2	neurol	neurol	PROPN
fnp-3806	3145	3	2017;74:91	2017;74:91	NUM
fnp-3806	3145	4	-	-	SYM
fnp-3806	3145	5	99	99	NUM
fnp-3806	3145	6	.	.	PUNCT
fnp-3806	3146	1	https://doi.org/10.1001/jamaneurol.2016.4370	https://doi.org/10.1001/jamaneurol.2016.4370	PROPN
fnp-3806	3146	2	heneka	heneka	VERB
fnp-3806	3146	3	mt	mt	PROPN
fnp-3806	3146	4	,	,	PUNCT
fnp-3806	3146	5	sastre	sastre	NOUN
fnp-3806	3146	6	m	m	PROPN
fnp-3806	3146	7	,	,	PUNCT
fnp-3806	3146	8	dumitrescu	dumitrescu	NOUN
fnp-3806	3146	9	-	-	PUNCT
fnp-3806	3146	10	ozimek	ozimek	NOUN
fnp-3806	3146	11	l	l	NOUN
fnp-3806	3146	12	,	,	PUNCT
fnp-3806	3146	13	et	et	PROPN
fnp-3806	3146	14	al	al	PROPN
fnp-3806	3146	15	.	.	PROPN
fnp-3806	3147	1	focal	focal	ADJ
fnp-3806	3147	2	glial	glial	ADJ
fnp-3806	3147	3	activation	activation	NOUN
fnp-3806	3147	4	coincides	coincide	VERB
fnp-3806	3147	5	with	with	ADP
fnp-3806	3147	6	increased	increase	VERB
fnp-3806	3147	7	bace1	bace1	NOUN
fnp-3806	3147	8	activation	activation	NOUN
fnp-3806	3147	9	and	and	CCONJ
fnp-3806	3147	10	precedes	precede	VERB
fnp-3806	3147	11	amyloid	amyloid	NOUN
fnp-3806	3147	12	plaque	plaque	NOUN
fnp-3806	3147	13	deposition	deposition	NOUN
fnp-3806	3147	14	in	in	ADP
fnp-3806	3147	15	app[v717i	app[v717i	VERB
fnp-3806	3147	16	]	]	PUNCT
fnp-3806	3147	17	transgenic	transgenic	NOUN
fnp-3806	3147	18	mice	mouse	NOUN
fnp-3806	3147	19	.	.	PUNCT
fnp-3806	3148	1	j	j	PROPN
fnp-3806	3148	2	neuroinflammation	neuroinflammation	PROPN
fnp-3806	3148	3	2005;2	2005;2	NUM
fnp-3806	3148	4	:	:	PUNCT
fnp-3806	3148	5	22	22	NUM
fnp-3806	3148	6	.	.	PUNCT
fnp-3806	3149	1	https://doi.org/10.1186/1742-2094-2-22	https://doi.org/10.1186/1742-2094-2-22	X
fnp-3806	3149	2	rodríguez	rodríguez	VERB
fnp-3806	3149	3	jj	jj	PROPN
fnp-3806	3149	4	,	,	PUNCT
fnp-3806	3149	5	olabarria	olabarria	PROPN
fnp-3806	3149	6	m	m	PROPN
fnp-3806	3149	7	,	,	PUNCT
fnp-3806	3149	8	chvatal	chvatal	PROPN
fnp-3806	3149	9	a	a	X
fnp-3806	3149	10	,	,	PUNCT
fnp-3806	3149	11	et	et	PROPN
fnp-3806	3149	12	al	al	PROPN
fnp-3806	3149	13	.	.	PROPN
fnp-3806	3149	14	astroglia	astroglia	PROPN
fnp-3806	3149	15	in	in	ADP
fnp-3806	3149	16	dementia	dementia	NOUN
fnp-3806	3149	17	and	and	CCONJ
fnp-3806	3149	18	alzheimer	alzheimer	PROPN
fnp-3806	3149	19	's	's	PART
fnp-3806	3149	20	disease	disease	NOUN
fnp-3806	3149	21	.	.	PUNCT
fnp-3806	3150	1	cell	cell	NOUN
fnp-3806	3150	2	death	death	NOUN
fnp-3806	3150	3	differ	differ	VERB
fnp-3806	3150	4	2009;16	2009;16	NOUN
fnp-3806	3150	5	:	:	PUNCT
fnp-3806	3150	6	378	378	NUM
fnp-3806	3150	7	-	-	SYM
fnp-3806	3150	8	385	385	NUM
fnp-3806	3150	9	.	.	PUNCT
fnp-3806	3151	1	https://doi.org/10.1038/cdd.2008.172	https://doi.org/10.1038/cdd.2008.172	PROPN
fnp-3806	3151	2	rodríguez	rodríguez	PROPN
fnp-3806	3151	3	-	-	PUNCT
fnp-3806	3151	4	arellano	arellano	PROPN
fnp-3806	3151	5	jj	jj	PROPN
fnp-3806	3151	6	,	,	PUNCT
fnp-3806	3151	7	parpura	parpura	NOUN
fnp-3806	3151	8	v	v	NOUN
fnp-3806	3151	9	,	,	PUNCT
fnp-3806	3151	10	zorec	zorec	X
fnp-3806	3151	11	r	r	NOUN
fnp-3806	3151	12	,	,	PUNCT
fnp-3806	3151	13	et	et	PROPN
fnp-3806	3151	14	al	al	PROPN
fnp-3806	3151	15	.	.	PROPN
fnp-3806	3151	16	astrocytes	astrocyte	NOUN
fnp-3806	3151	17	in	in	ADP
fnp-3806	3151	18	physiological	physiological	ADJ
fnp-3806	3151	19	aging	aging	NOUN
fnp-3806	3151	20	and	and	CCONJ
fnp-3806	3151	21	alzheimer	alzheimer	NOUN
fnp-3806	3151	22	's	's	PART
fnp-3806	3151	23	disease	disease	NOUN
fnp-3806	3151	24	.	.	PUNCT
fnp-3806	3152	1	neuroscience	neuroscience	NOUN
fnp-3806	3152	2	2016;323:170	2016;323:170	NUM
fnp-3806	3152	3	-	-	SYM
fnp-3806	3152	4	182	182	NUM
fnp-3806	3152	5	.	.	PUNCT
fnp-3806	3153	1	https://doi.org/10.1016/j.neuroscience.2015.01.007	https://doi.org/10.1016/j.neuroscience.2015.01.007	VERB
fnp-3806	3153	2	verkhratsky	verkhratsky	ADP
fnp-3806	3153	3	a	a	PRON
fnp-3806	3153	4	,	,	PUNCT
fnp-3806	3153	5	rodríguez	rodríguez	NOUN
fnp-3806	3153	6	jj	jj	PROPN
fnp-3806	3153	7	,	,	PUNCT
fnp-3806	3153	8	parpura	parpura	NOUN
fnp-3806	3153	9	v.	v.	PROPN
fnp-3806	3153	10	neuroglia	neuroglia	PROPN
fnp-3806	3153	11	in	in	ADP
fnp-3806	3153	12	ageing	ageing	NOUN
fnp-3806	3153	13	and	and	CCONJ
fnp-3806	3153	14	disease	disease	NOUN
fnp-3806	3153	15	.	.	PUNCT
fnp-3806	3154	1	cell	cell	NOUN
fnp-3806	3154	2	tissue	tissue	NOUN
fnp-3806	3154	3	res	re	NOUN
fnp-3806	3154	4	2014;357	2014;357	NUM
fnp-3806	3154	5	:	:	PUNCT
fnp-3806	3154	6	493	493	NUM
fnp-3806	3154	7	-	-	SYM
fnp-3806	3154	8	503	503	NUM
fnp-3806	3154	9	.	.	PUNCT
fnp-3806	3155	1	https://doi.org/10.1007/s00441-014-1814-z	https://doi.org/10.1007/s00441-014-1814-z	NOUN
fnp-3806	3155	2	verkhratsky	verkhratsky	VERB
fnp-3806	3155	3	a	a	PRON
fnp-3806	3155	4	,	,	PUNCT
fnp-3806	3155	5	zorec	zorec	NOUN
fnp-3806	3155	6	r	r	NOUN
fnp-3806	3155	7	,	,	PUNCT
fnp-3806	3155	8	rodríguez	rodríguez	PROPN
fnp-3806	3155	9	jj	jj	PROPN
fnp-3806	3155	10	,	,	PUNCT
fnp-3806	3155	11	et	et	PROPN
fnp-3806	3155	12	al	al	PROPN
fnp-3806	3155	13	.	.	PUNCT
fnp-3806	3156	1	astroglia	astroglia	PROPN
fnp-3806	3156	2	dynamics	dynamic	NOUN
fnp-3806	3156	3	in	in	ADP
fnp-3806	3156	4	ageing	ageing	NOUN
fnp-3806	3156	5	and	and	CCONJ
fnp-3806	3156	6	alzheimer	alzheimer	NOUN
fnp-3806	3156	7	's	's	PART
fnp-3806	3156	8	disease	disease	NOUN
fnp-3806	3156	9	.	.	PUNCT
fnp-3806	3157	1	curr	curr	PROPN
fnp-3806	3157	2	opin	opin	PROPN
fnp-3806	3157	3	pharmacol	pharmacol	PROPN
fnp-3806	3157	4	2016;26	2016;26	NUM
fnp-3806	3157	5	:	:	PUNCT
fnp-3806	3157	6	74	74	NUM
fnp-3806	3157	7	-	-	SYM
fnp-3806	3157	8	79	79	NUM
fnp-3806	3157	9	.	.	PUNCT
fnp-3806	3158	1	https://doi.org/10.1016/j.coph.2015.09.011	https://doi.org/10.1016/j.coph.2015.09.011	PROPN
fnp-3806	3158	2	nagy	nagy	PROPN
fnp-3806	3158	3	ji	ji	PROPN
fnp-3806	3158	4	,	,	PUNCT
fnp-3806	3158	5	li	li	PROPN
fnp-3806	3158	6	w	w	PROPN
fnp-3806	3158	7	,	,	PUNCT
fnp-3806	3158	8	hertzberg	hertzberg	PROPN
fnp-3806	3158	9	el	el	PROPN
fnp-3806	3158	10	,	,	PUNCT
fnp-3806	3158	11	marotta	marotta	PROPN
fnp-3806	3158	12	ca	ca	NOUN
fnp-3806	3158	13	.	.	PUNCT
fnp-3806	3159	1	elevated	elevated	ADJ
fnp-3806	3159	2	connexin43	connexin43	NOUN
fnp-3806	3159	3	immunoreactivity	immunoreactivity	NOUN
fnp-3806	3159	4	at	at	ADP
fnp-3806	3159	5	sites	site	NOUN
fnp-3806	3159	6	of	of	ADP
fnp-3806	3159	7	amyloid	amyloid	NOUN
fnp-3806	3159	8	plaques	plaque	NOUN
fnp-3806	3159	9	in	in	ADP
fnp-3806	3159	10	alzheimer	alzheimer	PROPN
fnp-3806	3159	11	's	's	PART
fnp-3806	3159	12	disease	disease	NOUN
fnp-3806	3159	13	.	.	PUNCT
fnp-3806	3160	1	brain	brain	NOUN
fnp-3806	3160	2	res	re	NOUN
fnp-3806	3160	3	1996;717	1996;717	NUM
fnp-3806	3160	4	:	:	PUNCT
fnp-3806	3160	5	173	173	NUM
fnp-3806	3160	6	-	-	SYM
fnp-3806	3160	7	178	178	NUM
fnp-3806	3160	8	.	.	PUNCT
fnp-3806	3161	1	https://doi.org/10.1016/0006-8993(95)01526-4	https://doi.org/10.1016/0006-8993(95)01526-4	PROPN
fnp-3806	3161	2	kuchibhotla	kuchibhotla	PROPN
fnp-3806	3161	3	kv	kv	PROPN
fnp-3806	3161	4	,	,	PUNCT
fnp-3806	3161	5	lattarulo	lattarulo	ADP
fnp-3806	3161	6	cr	cr	PROPN
fnp-3806	3161	7	,	,	PUNCT
fnp-3806	3161	8	hyman	hyman	PROPN
fnp-3806	3161	9	bt	bt	PROPN
fnp-3806	3161	10	,	,	PUNCT
fnp-3806	3161	11	et	et	PROPN
fnp-3806	3161	12	al	al	PROPN
fnp-3806	3161	13	.	.	PROPN
fnp-3806	3162	1	synchronous	synchronous	ADJ
fnp-3806	3162	2	hyperactivity	hyperactivity	NOUN
fnp-3806	3162	3	and	and	CCONJ
fnp-3806	3162	4	intercellular	intercellular	ADJ
fnp-3806	3162	5	calcium	calcium	NOUN
fnp-3806	3162	6	waves	wave	NOUN
fnp-3806	3162	7	in	in	ADP
fnp-3806	3162	8	astrocytes	astrocyte	NOUN
fnp-3806	3162	9	in	in	ADP
fnp-3806	3162	10	alzheimer	alzheimer	PROPN
fnp-3806	3162	11	mice	mouse	NOUN
fnp-3806	3162	12	.	.	PUNCT
fnp-3806	3163	1	science	science	NOUN
fnp-3806	3163	2	2009	2009	NUM
fnp-3806	3163	3	;	;	PUNCT
fnp-3806	3163	4	323	323	NUM
fnp-3806	3163	5	:	:	SYM
fnp-3806	3163	6	1211	1211	NUM
fnp-3806	3163	7	-	-	SYM
fnp-3806	3163	8	1215	1215	NUM
fnp-3806	3163	9	.	.	PUNCT
fnp-3806	3164	1	https://doi.org/10.1126/science.1169096	https://doi.org/10.1126/science.1169096	PROPN
fnp-3806	3164	2	abramov	abramov	PROPN
fnp-3806	3164	3	ay	ay	PROPN
fnp-3806	3164	4	,	,	PUNCT
fnp-3806	3164	5	canevari	canevari	PROPN
fnp-3806	3164	6	l	l	NOUN
fnp-3806	3164	7	,	,	PUNCT
fnp-3806	3164	8	duchen	duchen	PROPN
fnp-3806	3164	9	mr	mr	PROPN
fnp-3806	3164	10	.	.	PROPN
fnp-3806	3164	11	calcium	calcium	NOUN
fnp-3806	3164	12	signals	signal	NOUN
fnp-3806	3164	13	induced	induce	VERB
fnp-3806	3164	14	by	by	ADP
fnp-3806	3164	15	amyloid	amyloid	NOUN
fnp-3806	3164	16	beta	beta	NOUN
fnp-3806	3164	17	peptide	peptide	NOUN
fnp-3806	3164	18	and	and	CCONJ
fnp-3806	3164	19	their	their	PRON
fnp-3806	3164	20	consequences	consequence	NOUN
fnp-3806	3164	21	in	in	ADP
fnp-3806	3164	22	neurons	neuron	NOUN
fnp-3806	3164	23	and	and	CCONJ
fnp-3806	3164	24	astrocytes	astrocyte	NOUN
fnp-3806	3164	25	in	in	ADP
fnp-3806	3164	26	culture	culture	NOUN
fnp-3806	3164	27	.	.	PUNCT
fnp-3806	3165	1	biochim	biochim	PROPN
fnp-3806	3165	2	biophys	biophy	NOUN
fnp-3806	3165	3	acta	acta	PROPN
fnp-3806	3165	4	2004;1742	2004;1742	NUM
fnp-3806	3165	5	:	:	PUNCT
fnp-3806	3165	6	81	81	NUM
fnp-3806	3165	7	-	-	SYM
fnp-3806	3165	8	87	87	NUM
fnp-3806	3165	9	.	.	PUNCT
fnp-3806	3166	1	https://doi.org/10.1016/j.bbamcr.2004.09.006	https://doi.org/10.1016/j.bbamcr.2004.09.006	PROPN
fnp-3806	3166	2	simpson	simpson	PROPN
fnp-3806	3166	3	je	je	PROPN
fnp-3806	3166	4	,	,	PUNCT
fnp-3806	3166	5	ince	ince	PROPN
fnp-3806	3166	6	pg	pg	PROPN
fnp-3806	3166	7	,	,	PUNCT
fnp-3806	3166	8	shaw	shaw	PROPN
fnp-3806	3166	9	pj	pj	PROPN
fnp-3806	3166	10	,	,	PUNCT
fnp-3806	3166	11	et	et	PROPN
fnp-3806	3166	12	al	al	PROPN
fnp-3806	3166	13	.	.	PROPN
fnp-3806	3166	14	microarray	microarray	PROPN
fnp-3806	3166	15	analysis	analysis	NOUN
fnp-3806	3166	16	of	of	ADP
fnp-3806	3166	17	the	the	DET
fnp-3806	3166	18	astrocyte	astrocyte	NOUN
fnp-3806	3166	19	transcriptome	transcriptome	NOUN
fnp-3806	3166	20	in	in	ADP
fnp-3806	3166	21	the	the	DET
fnp-3806	3166	22	aging	age	VERB
fnp-3806	3166	23	brain	brain	NOUN
fnp-3806	3166	24	:	:	PUNCT
fnp-3806	3166	25	relationship	relationship	NOUN
fnp-3806	3166	26	to	to	ADP
fnp-3806	3166	27	alzheimer	alzheimer	PROPN
fnp-3806	3166	28	's	's	PART
fnp-3806	3166	29	pathology	pathology	NOUN
fnp-3806	3166	30	and	and	CCONJ
fnp-3806	3166	31	apoe	apoe	ADJ
fnp-3806	3166	32	genotype	genotype	NOUN
fnp-3806	3166	33	.	.	PUNCT
fnp-3806	3167	1	neurobiol	neurobiol	PROPN
fnp-3806	3167	2	aging	age	VERB
fnp-3806	3167	3	2011;32	2011;32	NUM
fnp-3806	3167	4	:	:	PUNCT
fnp-3806	3167	5	1795	1795	NUM
fnp-3806	3167	6	-	-	SYM
fnp-3806	3167	7	1807	1807	NUM
fnp-3806	3167	8	.	.	PUNCT
fnp-3806	3168	1	https://doi.org/10.1016/j.neurobiolaging.2011.04.013	https://doi.org/10.1016/j.neurobiolaging.2011.04.013	NOUN
fnp-3806	3168	2	galea	galea	NOUN
fnp-3806	3168	3	e	e	NOUN
fnp-3806	3168	4	,	,	PUNCT
fnp-3806	3168	5	weinstock	weinstock	PROPN
fnp-3806	3168	6	ld	ld	PROPN
fnp-3806	3168	7	,	,	PUNCT
fnp-3806	3168	8	larramona	larramona	NOUN
fnp-3806	3168	9	-	-	PUNCT
fnp-3806	3168	10	arcas	arcas	NOUN
fnp-3806	3168	11	r	r	NOUN
fnp-3806	3168	12	,	,	PUNCT
fnp-3806	3168	13	et	et	PROPN
fnp-3806	3168	14	al	al	PROPN
fnp-3806	3168	15	.	.	PUNCT
fnp-3806	3169	1	multi	multi	ADJ
fnp-3806	3169	2	-	-	ADJ
fnp-3806	3169	3	transcriptomic	transcriptomic	ADJ
fnp-3806	3169	4	analysis	analysis	NOUN
fnp-3806	3169	5	points	point	NOUN
fnp-3806	3169	6	to	to	ADP
fnp-3806	3169	7	early	early	ADJ
fnp-3806	3169	8	organelle	organelle	NOUN
fnp-3806	3169	9	dysfunction	dysfunction	NOUN
fnp-3806	3169	10	in	in	ADP
fnp-3806	3169	11	human	human	ADJ
fnp-3806	3169	12	astrocytes	astrocyte	NOUN
fnp-3806	3169	13	in	in	ADP
fnp-3806	3169	14	alzheimer	alzheimer	PROPN
fnp-3806	3169	15	's	's	PART
fnp-3806	3169	16	disease	disease	NOUN
fnp-3806	3169	17	.	.	PUNCT
fnp-3806	3170	1	neurobiol	neurobiol	PROPN
fnp-3806	3170	2	dis	dis	PROPN
fnp-3806	3171	1	2022;166:105655	2022;166:105655	NUM
fnp-3806	3171	2	.	.	PUNCT
fnp-3806	3172	1	https://doi.org/10.1016/j.nbd.2022.105655	https://doi.org/10.1016/j.nbd.2022.105655	PROPN
fnp-3806	3172	2	simpson	simpson	PROPN
fnp-3806	3172	3	je	je	PROPN
fnp-3806	3172	4	,	,	PUNCT
fnp-3806	3172	5	ince	ince	PROPN
fnp-3806	3172	6	pg	pg	PROPN
fnp-3806	3172	7	,	,	PUNCT
fnp-3806	3172	8	lace	lace	NOUN
fnp-3806	3172	9	g	g	NOUN
fnp-3806	3172	10	,	,	PUNCT
fnp-3806	3172	11	et	et	PROPN
fnp-3806	3172	12	al	al	PROPN
fnp-3806	3172	13	.	.	PROPN
fnp-3806	3172	14	astrocyte	astrocyte	PROPN
fnp-3806	3172	15	phenotype	phenotype	NOUN
fnp-3806	3172	16	in	in	ADP
fnp-3806	3172	17	relation	relation	NOUN
fnp-3806	3172	18	to	to	ADP
fnp-3806	3172	19	alzheimer	alzheimer	ADJ
fnp-3806	3172	20	-	-	PUNCT
fnp-3806	3172	21	type	type	NOUN
fnp-3806	3172	22	pathology	pathology	NOUN
fnp-3806	3172	23	in	in	ADP
fnp-3806	3172	24	the	the	DET
fnp-3806	3172	25	ageing	age	VERB
fnp-3806	3172	26	brain	brain	NOUN
fnp-3806	3172	27	.	.	PUNCT
fnp-3806	3173	1	neurobiol	neurobiol	PROPN
fnp-3806	3173	2	aging	age	VERB
fnp-3806	3173	3	2010;31	2010;31	NUM
fnp-3806	3173	4	:	:	PUNCT
fnp-3806	3173	5	578	578	NUM
fnp-3806	3173	6	-	-	SYM
fnp-3806	3173	7	590	590	NUM
fnp-3806	3173	8	.	.	PUNCT
fnp-3806	3174	1	https://doi.org/10.1016/j.neurobiolaging	https://doi.org/10.1016/j.neurobiolage	VERB
fnp-3806	3174	2	2008.05.015	2008.05.015	PROPN
fnp-3806	3174	3	.	.	PUNCT
fnp-3806	3175	1	kamphuis	kamphuis	PROPN
fnp-3806	3175	2	w	w	PROPN
fnp-3806	3175	3	,	,	PUNCT
fnp-3806	3175	4	middeldorp	middeldorp	PROPN
fnp-3806	3175	5	j	j	PROPN
fnp-3806	3175	6	,	,	PUNCT
fnp-3806	3175	7	kooijman	kooijman	PROPN
fnp-3806	3175	8	l	l	PROPN
fnp-3806	3175	9	,	,	PUNCT
fnp-3806	3175	10	et	et	PROPN
fnp-3806	3175	11	al	al	PROPN
fnp-3806	3175	12	.	.	PUNCT
fnp-3806	3176	1	glial	glial	ADJ
fnp-3806	3176	2	fibrillary	fibrillary	ADJ
fnp-3806	3176	3	acidic	acidic	ADJ
fnp-3806	3176	4	protein	protein	NOUN
fnp-3806	3176	5	isoform	isoform	NOUN
fnp-3806	3176	6	expression	expression	NOUN
fnp-3806	3176	7	in	in	ADP
fnp-3806	3176	8	plaque	plaque	NOUN
fnp-3806	3176	9	related	relate	VERB
fnp-3806	3176	10	astrogliosis	astrogliosis	NOUN
fnp-3806	3176	11	in	in	ADP
fnp-3806	3176	12	alzheimer	alzheimer	PROPN
fnp-3806	3176	13	's	's	PART
fnp-3806	3176	14	disease	disease	NOUN
fnp-3806	3176	15	.	.	PUNCT
fnp-3806	3177	1	neurobiol	neurobiol	PROPN
fnp-3806	3177	2	aging	age	VERB
fnp-3806	3177	3	2014;35	2014;35	NUM
fnp-3806	3177	4	:	:	PUNCT
fnp-3806	3177	5	492	492	NUM
fnp-3806	3177	6	-	-	SYM
fnp-3806	3177	7	510	510	NUM
fnp-3806	3177	8	.	.	PUNCT
fnp-3806	3178	1	https://doi.org/10.1016/j.neurobiolaging.2013.09.035	https://doi.org/10.1016/j.neurobiolaging.2013.09.035	PROPN
fnp-3806	3178	2	beach	beach	PROPN
fnp-3806	3178	3	tg	tg	PROPN
fnp-3806	3178	4	,	,	PUNCT
fnp-3806	3178	5	mcgeer	mcgeer	PROPN
fnp-3806	3178	6	eg	eg	PROPN
fnp-3806	3178	7	.	.	PUNCT
fnp-3806	3179	1	lamina	lamina	ADJ
fnp-3806	3179	2	-	-	ADJ
fnp-3806	3179	3	specific	specific	ADJ
fnp-3806	3179	4	arrangement	arrangement	NOUN
fnp-3806	3179	5	of	of	ADP
fnp-3806	3179	6	astrocytic	astrocytic	ADJ
fnp-3806	3179	7	gliosis	gliosis	NOUN
fnp-3806	3179	8	and	and	CCONJ
fnp-3806	3179	9	senile	senile	ADJ
fnp-3806	3179	10	plaques	plaque	NOUN
fnp-3806	3179	11	in	in	ADP
fnp-3806	3179	12	alzheimer	alzheimer	PROPN
fnp-3806	3179	13	's	's	PART
fnp-3806	3179	14	disease	disease	NOUN
fnp-3806	3179	15	visual	visual	ADJ
fnp-3806	3179	16	cortex	cortex	NOUN
fnp-3806	3179	17	.	.	PUNCT
fnp-3806	3180	1	brain	brain	NOUN
fnp-3806	3180	2	res	re	NOUN
fnp-3806	3180	3	1988;463	1988;463	NUM
fnp-3806	3180	4	:	:	PUNCT
fnp-3806	3180	5	357	357	NUM
fnp-3806	3180	6	-	-	SYM
fnp-3806	3180	7	361	361	NUM
fnp-3806	3180	8	.	.	PUNCT
fnp-3806	3181	1	https://doi.org/10.1016/0006-8993(88)90410-6	https://doi.org/10.1016/0006-8993(88)90410-6	PROPN
fnp-3806	3181	2	yin	yin	PROPN
fnp-3806	3181	3	kj	kj	PROPN
fnp-3806	3181	4	,	,	PUNCT
fnp-3806	3181	5	cirrito	cirrito	PROPN
fnp-3806	3181	6	jr	jr	PROPN
fnp-3806	3181	7	,	,	PUNCT
fnp-3806	3181	8	yan	yan	PROPN
fnp-3806	3182	1	p	p	X
fnp-3806	3182	2	,	,	PUNCT
fnp-3806	3182	3	et	et	PROPN
fnp-3806	3182	4	al	al	PROPN
fnp-3806	3182	5	.	.	PROPN
fnp-3806	3182	6	matrix	matrix	NOUN
fnp-3806	3182	7	metalloproteinases	metalloproteinase	NOUN
fnp-3806	3182	8	expressed	express	VERB
fnp-3806	3182	9	by	by	ADP
fnp-3806	3182	10	astrocytes	astrocyte	NOUN
fnp-3806	3182	11	mediate	mediate	VERB
fnp-3806	3182	12	extracellular	extracellular	ADJ
fnp-3806	3182	13	amyloid	amyloid	NOUN
fnp-3806	3182	14	-	-	PUNCT
fnp-3806	3182	15	beta	beta	NOUN
fnp-3806	3182	16	peptide	peptide	NOUN
fnp-3806	3182	17	catabolism	catabolism	NOUN
fnp-3806	3182	18	.	.	PUNCT
fnp-3806	3183	1	j	j	PROPN
fnp-3806	3183	2	neurosci	neurosci	PROPN
fnp-3806	3183	3	2006;26:10939	2006;26:10939	NUM
fnp-3806	3183	4	-	-	SYM
fnp-3806	3183	5	10948	10948	NUM
fnp-3806	3183	6	.	.	PUNCT
fnp-3806	3184	1	https://doi.org/10.1523/jneurosci	https://doi.org/10.1523/jneurosci	PROPN
fnp-3806	3184	2	2085	2085	NUM
fnp-3806	3184	3	-	-	SYM
fnp-3806	3184	4	06.2006	06.2006	NUM
fnp-3806	3184	5	.	.	PUNCT
fnp-3806	3185	1	yang	yang	PROPN
fnp-3806	3185	2	y	y	PROPN
fnp-3806	3185	3	,	,	PUNCT
fnp-3806	3185	4	estrada	estrada	PROPN
fnp-3806	3185	5	ey	ey	PROPN
fnp-3806	3185	6	,	,	PUNCT
fnp-3806	3185	7	thompson	thompson	PROPN
fnp-3806	3185	8	jf	jf	PROPN
fnp-3806	3185	9	,	,	PUNCT
fnp-3806	3185	10	et	et	PROPN
fnp-3806	3185	11	al	al	PROPN
fnp-3806	3185	12	.	.	PROPN
fnp-3806	3185	13	matrix	matrix	NOUN
fnp-3806	3185	14	metalloproteinase	metalloproteinase	NOUN
fnp-3806	3185	15	-	-	PUNCT
fnp-3806	3185	16	mediated	mediate	VERB
fnp-3806	3185	17	disruption	disruption	NOUN
fnp-3806	3185	18	of	of	ADP
fnp-3806	3185	19	tight	tight	ADJ
fnp-3806	3185	20	junction	junction	NOUN
fnp-3806	3185	21	proteins	protein	NOUN
fnp-3806	3185	22	in	in	ADP
fnp-3806	3185	23	cerebral	cerebral	ADJ
fnp-3806	3185	24	vessels	vessel	NOUN
fnp-3806	3185	25	is	be	AUX
fnp-3806	3185	26	reversed	reverse	VERB
fnp-3806	3185	27	by	by	ADP
fnp-3806	3185	28	synthetic	synthetic	ADJ
fnp-3806	3185	29	matrix	matrix	NOUN
fnp-3806	3185	30	metalloproteinase	metalloproteinase	NOUN
fnp-3806	3185	31	inhibitor	inhibitor	NOUN
fnp-3806	3185	32	in	in	ADP
fnp-3806	3185	33	focal	focal	ADJ
fnp-3806	3185	34	ischemia	ischemia	NOUN
fnp-3806	3185	35	in	in	ADP
fnp-3806	3185	36	rat	rat	PROPN
fnp-3806	3185	37	.	.	PUNCT
fnp-3806	3186	1	j	j	PROPN
fnp-3806	3186	2	cereb	cereb	PROPN
fnp-3806	3186	3	blood	blood	NOUN
fnp-3806	3186	4	flow	flow	NOUN
fnp-3806	3186	5	metab	metab	NOUN
fnp-3806	3186	6	2007;27:697	2007;27:697	PROPN
fnp-3806	3186	7	-	-	SYM
fnp-3806	3186	8	709	709	NUM
fnp-3806	3186	9	.	.	PUNCT
fnp-3806	3187	1	https://doi.org/10.1038/sj.jcbfm.9600375	https://doi.org/10.1038/sj.jcbfm.9600375	NOUN
fnp-3806	3187	2	miners	miner	NOUN
fnp-3806	3187	3	js	js	PROPN
fnp-3806	3187	4	,	,	PUNCT
fnp-3806	3187	5	van	van	PROPN
fnp-3806	3187	6	helmond	helmond	PROPN
fnp-3806	3187	7	z	z	PROPN
fnp-3806	3187	8	,	,	PUNCT
fnp-3806	3187	9	kehoe	kehoe	PROPN
fnp-3806	3187	10	pg	pg	PROPN
fnp-3806	3187	11	,	,	PUNCT
fnp-3806	3187	12	et	et	PROPN
fnp-3806	3187	13	al	al	PROPN
fnp-3806	3187	14	.	.	PROPN
fnp-3806	3188	1	changes	change	NOUN
fnp-3806	3188	2	with	with	ADP
fnp-3806	3188	3	age	age	NOUN
fnp-3806	3188	4	in	in	ADP
fnp-3806	3188	5	the	the	DET
fnp-3806	3188	6	activities	activity	NOUN
fnp-3806	3188	7	of	of	ADP
fnp-3806	3188	8	beta	beta	NOUN
fnp-3806	3188	9	-	-	PUNCT
fnp-3806	3188	10	secretase	secretase	NOUN
fnp-3806	3188	11	and	and	CCONJ
fnp-3806	3188	12	the	the	DET
fnp-3806	3188	13	abeta	abeta	ADV
fnp-3806	3188	14	-	-	PUNCT
fnp-3806	3188	15	degrading	degrade	VERB
fnp-3806	3188	16	enzymes	enzyme	NOUN
fnp-3806	3188	17	neprilysin	neprilysin	NOUN
fnp-3806	3188	18	,	,	PUNCT
fnp-3806	3188	19	insulin	insulin	NOUN
fnp-3806	3188	20	-	-	PUNCT
fnp-3806	3188	21	degrading	degrade	VERB
fnp-3806	3188	22	enzyme	enzyme	NOUN
fnp-3806	3188	23	and	and	CCONJ
fnp-3806	3188	24	angiotensin	angiotensin	NOUN
fnp-3806	3188	25	-	-	PUNCT
fnp-3806	3188	26	converting	convert	VERB
fnp-3806	3188	27	enzyme	enzyme	NOUN
fnp-3806	3188	28	.	.	PUNCT
fnp-3806	3189	1	brain	brain	NOUN
fnp-3806	3189	2	pathol	pathol	PROPN
fnp-3806	3189	3	2010;20:794	2010;20:794	PROPN
fnp-3806	3189	4	-	-	SYM
fnp-3806	3189	5	802	802	NUM
fnp-3806	3189	6	.	.	PUNCT
fnp-3806	3190	1	https://doi.org/10.1111/j.1750-3639.2010.00375.x	https://doi.org/10.1111/j.1750-3639.2010.00375.x	PROPN
fnp-3806	3190	2	carrano	carrano	PROPN
fnp-3806	3190	3	a	a	X
fnp-3806	3190	4	,	,	PUNCT
fnp-3806	3190	5	hoozemans	hoozemans	PROPN
fnp-3806	3190	6	jj	jj	PROPN
fnp-3806	3190	7	,	,	PUNCT
fnp-3806	3190	8	van	van	PROPN
fnp-3806	3190	9	der	der	PROPN
fnp-3806	3190	10	vies	vie	VERB
fnp-3806	3190	11	sm	sm	PROPN
fnp-3806	3190	12	,	,	PUNCT
fnp-3806	3190	13	et	et	PROPN
fnp-3806	3190	14	al	al	PROPN
fnp-3806	3190	15	.	.	PUNCT
fnp-3806	3190	16	neuroinflammation	neuroinflammation	NOUN
fnp-3806	3190	17	and	and	CCONJ
fnp-3806	3190	18	blood	blood	NOUN
fnp-3806	3190	19	-	-	PUNCT
fnp-3806	3190	20	brain	brain	NOUN
fnp-3806	3190	21	barrier	barrier	NOUN
fnp-3806	3190	22	changes	change	NOUN
fnp-3806	3190	23	in	in	ADP
fnp-3806	3190	24	capillary	capillary	ADJ
fnp-3806	3190	25	amyloid	amyloid	NOUN
fnp-3806	3190	26	angiopathy	angiopathy	NOUN
fnp-3806	3190	27	.	.	PUNCT
fnp-3806	3191	1	neurodegener	neurodegener	NOUN
fnp-3806	3191	2	dis	dis	PROPN
fnp-3806	3191	3	2012;10:329	2012;10:329	PROPN
fnp-3806	3191	4	-	-	PUNCT
fnp-3806	3191	5	331	331	NUM
fnp-3806	3191	6	.	.	PUNCT
fnp-3806	3192	1	https://doi.org/10.1159/000334916	https://doi.org/10.1159/000334916	PROPN
fnp-3806	3192	2	han	han	PROPN
fnp-3806	3192	3	bh	bh	PROPN
fnp-3806	3192	4	,	,	PUNCT
fnp-3806	3192	5	zhou	zhou	PROPN
fnp-3806	3192	6	ml	ml	PROPN
fnp-3806	3192	7	,	,	PUNCT
fnp-3806	3192	8	johnson	johnson	PROPN
fnp-3806	3192	9	aw	aw	INTJ
fnp-3806	3192	10	,	,	PUNCT
fnp-3806	3192	11	et	et	PROPN
fnp-3806	3192	12	al	al	PROPN
fnp-3806	3192	13	.	.	PROPN
fnp-3806	3192	14	contribution	contribution	NOUN
fnp-3806	3192	15	of	of	ADP
fnp-3806	3192	16	reactive	reactive	ADJ
fnp-3806	3192	17	oxygen	oxygen	NOUN
fnp-3806	3192	18	species	specie	NOUN
fnp-3806	3192	19	to	to	ADP
fnp-3806	3192	20	cerebral	cerebral	ADJ
fnp-3806	3192	21	amyloid	amyloid	NOUN
fnp-3806	3192	22	angiopathy	angiopathy	NOUN
fnp-3806	3192	23	,	,	PUNCT
fnp-3806	3192	24	vasomotor	vasomotor	NOUN
fnp-3806	3192	25	dysfunction	dysfunction	NOUN
fnp-3806	3192	26	,	,	PUNCT
fnp-3806	3192	27	and	and	CCONJ
fnp-3806	3192	28	microhemorrhage	microhemorrhage	NOUN
fnp-3806	3192	29	in	in	ADP
fnp-3806	3192	30	aged	aged	ADJ
fnp-3806	3192	31	tg2576	tg2576	PROPN
fnp-3806	3192	32	mice	mouse	NOUN
fnp-3806	3192	33	.	.	PUNCT
fnp-3806	3193	1	proc	proc	PROPN
fnp-3806	3193	2	natl	natl	PROPN
fnp-3806	3193	3	acad	acad	PROPN
fnp-3806	3193	4	sci	sci	PROPN
fnp-3806	3193	5	usa	usa	PROPN
fnp-3806	3193	6	2015;112	2015;112	NUM
fnp-3806	3193	7	:	:	PUNCT
fnp-3806	3193	8	e881–890	e881–890	PROPN
fnp-3806	3193	9	.	.	PUNCT
fnp-3806	3193	10	https://doi.org/10.1073/pnas.1414930112	https://doi.org/10.1073/pnas.1414930112	PROPN
fnp-3806	3193	11	funato	funato	PROPN
fnp-3806	3193	12	h	h	PROPN
fnp-3806	3193	13	,	,	PUNCT
fnp-3806	3193	14	yoshimura	yoshimura	PROPN
fnp-3806	3193	15	m	m	PROPN
fnp-3806	3193	16	,	,	PUNCT
fnp-3806	3193	17	yamazaki	yamazaki	PROPN
fnp-3806	3193	18	t	t	PROPN
fnp-3806	3193	19	,	,	PUNCT
fnp-3806	3193	20	et	et	PROPN
fnp-3806	3193	21	al	al	PROPN
fnp-3806	3193	22	.	.	PROPN
fnp-3806	3193	23	astrocytes	astrocyte	NOUN
fnp-3806	3193	24	containing	contain	VERB
fnp-3806	3193	25	amyloid	amyloid	NOUN
fnp-3806	3193	26	beta	beta	NOUN
fnp-3806	3193	27	-	-	PUNCT
fnp-3806	3193	28	protein	protein	NOUN
fnp-3806	3193	29	(	(	PUNCT
fnp-3806	3193	30	abeta)-positive	abeta)-positive	ADJ
fnp-3806	3193	31	granules	granule	NOUN
fnp-3806	3193	32	are	be	AUX
fnp-3806	3193	33	associated	associate	VERB
fnp-3806	3193	34	with	with	ADP
fnp-3806	3193	35	abeta40	abeta40	NOUN
fnp-3806	3193	36	-	-	PUNCT
fnp-3806	3193	37	positive	positive	ADJ
fnp-3806	3193	38	diffuse	diffuse	NOUN
fnp-3806	3193	39	plaques	plaque	NOUN
fnp-3806	3193	40	in	in	ADP
fnp-3806	3193	41	the	the	DET
fnp-3806	3193	42	aged	aged	ADJ
fnp-3806	3193	43	human	human	ADJ
fnp-3806	3193	44	brain	brain	NOUN
fnp-3806	3193	45	.	.	PUNCT
fnp-3806	3194	1	am	be	AUX
fnp-3806	3194	2	j	j	PROPN
fnp-3806	3194	3	pathol	pathol	NOUN
fnp-3806	3194	4	1988;152	1988;152	NUM
fnp-3806	3194	5	:	:	PUNCT
fnp-3806	3194	6	983	983	NUM
fnp-3806	3194	7	-	-	SYM
fnp-3806	3194	8	992	992	NUM
fnp-3806	3194	9	.	.	PUNCT
fnp-3806	3195	1	pmid	pmid	NOUN
fnp-3806	3195	2	:	:	PUNCT
fnp-3806	3195	3	9546359	9546359	NUM
fnp-3806	3195	4	.	.	PUNCT
fnp-3806	3196	1	guénette	guénette	PROPN
fnp-3806	3196	2	sy	sy	PROPN
fnp-3806	3196	3	.	.	PROPN
fnp-3806	3196	4	astrocytes	astrocytes	PROPN
fnp-3806	3196	5	:	:	PUNCT
fnp-3806	3196	6	a	a	DET
fnp-3806	3196	7	cellular	cellular	ADJ
fnp-3806	3196	8	player	player	NOUN
fnp-3806	3196	9	in	in	ADP
fnp-3806	3196	10	abeta	abeta	NOUN
fnp-3806	3196	11	clearance	clearance	NOUN
fnp-3806	3196	12	and	and	CCONJ
fnp-3806	3196	13	degradation	degradation	NOUN
fnp-3806	3196	14	.	.	PUNCT
fnp-3806	3197	1	trends	trend	NOUN
fnp-3806	3197	2	mol	mol	ADP
fnp-3806	3197	3	med	med	ADJ
fnp-3806	3197	4	2003;9	2003;9	NUM
fnp-3806	3197	5	:	:	PUNCT
fnp-3806	3197	6	279	279	NUM
fnp-3806	3197	7	-	-	SYM
fnp-3806	3197	8	280	280	NUM
fnp-3806	3197	9	.	.	PUNCT
fnp-3806	3198	1	https://doi.org/10.1016/s1471-4914(03)00112-6	https://doi.org/10.1016/s1471-4914(03)00112-6	ADJ
fnp-3806	3198	2	nagele	nagele	NOUN
fnp-3806	3198	3	rg	rg	PROPN
fnp-3806	3198	4	,	,	PUNCT
fnp-3806	3198	5	wegiel	wegiel	PROPN
fnp-3806	3198	6	j	j	PROPN
fnp-3806	3198	7	,	,	PUNCT
fnp-3806	3198	8	venkataraman	venkataraman	NOUN
fnp-3806	3198	9	v	v	NOUN
fnp-3806	3198	10	,	,	PUNCT
fnp-3806	3198	11	et	et	PROPN
fnp-3806	3198	12	al	al	PROPN
fnp-3806	3198	13	.	.	PROPN
fnp-3806	3198	14	contribution	contribution	NOUN
fnp-3806	3198	15	of	of	ADP
fnp-3806	3198	16	glial	glial	ADJ
fnp-3806	3198	17	cells	cell	NOUN
fnp-3806	3198	18	to	to	ADP
fnp-3806	3198	19	the	the	DET
fnp-3806	3198	20	development	development	NOUN
fnp-3806	3198	21	of	of	ADP
fnp-3806	3198	22	amyloid	amyloid	NOUN
fnp-3806	3198	23	plaques	plaque	NOUN
fnp-3806	3198	24	in	in	ADP
fnp-3806	3198	25	alzheimer	alzheimer	PROPN
fnp-3806	3198	26	's	's	PART
fnp-3806	3198	27	disease	disease	NOUN
fnp-3806	3198	28	.	.	PUNCT
fnp-3806	3199	1	neurobiol	neurobiol	PROPN
fnp-3806	3199	2	aging	age	VERB
fnp-3806	3199	3	2004;25	2004;25	NOUN
fnp-3806	3199	4	:	:	PUNCT
fnp-3806	3199	5	663	663	NUM
fnp-3806	3199	6	-	-	SYM
fnp-3806	3199	7	674	674	NUM
fnp-3806	3199	8	.	.	PUNCT
fnp-3806	3200	1	https://doi.org/10.1016/j.neurobiolaging	https://doi.org/10.1016/j.neurobiolage	VERB
fnp-3806	3200	2	2004.01.007	2004.01.007	NOUN
fnp-3806	3200	3	.	.	PUNCT
fnp-3806	3201	1	thal	thal	PROPN
fnp-3806	3201	2	dr	dr	PROPN
fnp-3806	3201	3	,	,	PUNCT
fnp-3806	3201	4	schultz	schultz	PROPN
fnp-3806	3201	5	c	c	PROPN
fnp-3806	3201	6	,	,	PUNCT
fnp-3806	3201	7	dehghani	dehghani	PROPN
fnp-3806	3201	8	f	f	AUX
fnp-3806	3201	9	,	,	PUNCT
fnp-3806	3201	10	et	et	PROPN
fnp-3806	3201	11	al	al	PROPN
fnp-3806	3201	12	.	.	PUNCT
fnp-3806	3201	13	amyloid	amyloid	PROPN
fnp-3806	3201	14	beta	beta	NOUN
fnp-3806	3201	15	-	-	PUNCT
fnp-3806	3201	16	protein	protein	NOUN
fnp-3806	3201	17	(	(	PUNCT
fnp-3806	3201	18	abeta)-containing	abeta)-containe	VERB
fnp-3806	3201	19	astrocytes	astrocyte	NOUN
fnp-3806	3201	20	are	be	AUX
fnp-3806	3201	21	located	locate	VERB
fnp-3806	3201	22	preferentially	preferentially	ADV
fnp-3806	3201	23	near	near	ADP
fnp-3806	3201	24	n	n	CCONJ
fnp-3806	3201	25	-	-	PUNCT
fnp-3806	3201	26	terminal	terminal	NOUN
fnp-3806	3201	27	-	-	PUNCT
fnp-3806	3201	28	truncated	truncate	VERB
fnp-3806	3201	29	abeta	abeta	NOUN
fnp-3806	3201	30	deposits	deposit	NOUN
fnp-3806	3201	31	in	in	ADP
fnp-3806	3201	32	the	the	DET
fnp-3806	3201	33	human	human	ADJ
fnp-3806	3201	34	entorhinal	entorhinal	ADJ
fnp-3806	3201	35	cortex	cortex	NOUN
fnp-3806	3201	36	.	.	PUNCT
fnp-3806	3202	1	acta	acta	PROPN
fnp-3806	3202	2	neuropathol	neuropathol	PROPN
fnp-3806	3202	3	2000;100	2000;100	PROPN
fnp-3806	3202	4	:	:	PUNCT
fnp-3806	3202	5	608	608	NUM
fnp-3806	3202	6	-	-	SYM
fnp-3806	3202	7	617	617	NUM
fnp-3806	3202	8	.	.	PUNCT
fnp-3806	3203	1	https://doi.org/10.1007/s004010000242	https://doi.org/10.1007/s004010000242	NUM
fnp-3806	3203	2	koistinaho	koistinaho	NOUN
fnp-3806	3203	3	m	m	PROPN
fnp-3806	3203	4	,	,	PUNCT
fnp-3806	3203	5	lin	lin	PROPN
fnp-3806	3203	6	s	s	PROPN
fnp-3806	3203	7	,	,	PUNCT
fnp-3806	3203	8	wu	wu	PROPN
fnp-3806	3203	9	x	x	PROPN
fnp-3806	3203	10	,	,	PUNCT
fnp-3806	3203	11	esterman	esterman	NOUN
fnp-3806	3203	12	m	m	PROPN
fnp-3806	3203	13	,	,	PUNCT
fnp-3806	3203	14	et	et	PROPN
fnp-3806	3203	15	al	al	PROPN
fnp-3806	3203	16	.	.	PROPN
fnp-3806	3203	17	apolipoprotein	apolipoprotein	PROPN
fnp-3806	3203	18	e	e	PROPN
fnp-3806	3203	19	promotes	promote	VERB
fnp-3806	3203	20	astrocyte	astrocyte	NOUN
fnp-3806	3203	21	colocalization	colocalization	NOUN
fnp-3806	3203	22	and	and	CCONJ
fnp-3806	3203	23	degradation	degradation	NOUN
fnp-3806	3203	24	of	of	ADP
fnp-3806	3203	25	deposited	deposit	VERB
fnp-3806	3203	26	amyloid	amyloid	NOUN
fnp-3806	3203	27	-	-	PUNCT
fnp-3806	3203	28	beta	beta	NOUN
fnp-3806	3203	29	peptides	peptide	NOUN
fnp-3806	3203	30	.	.	PUNCT
fnp-3806	3204	1	nat	nat	PROPN
fnp-3806	3204	2	med	med	PROPN
fnp-3806	3204	3	2004;10	2004;10	NUM
fnp-3806	3204	4	:	:	PUNCT
fnp-3806	3204	5	719	719	NUM
fnp-3806	3204	6	-	-	SYM
fnp-3806	3204	7	726	726	NUM
fnp-3806	3204	8	.	.	PUNCT
fnp-3806	3205	1	https://doi.org/10.1038/nm1058	https://doi.org/10.1038/nm1058	NUM
fnp-3806	3205	2	yan	yan	PROPN
fnp-3806	3205	3	p	p	X
fnp-3806	3205	4	,	,	PUNCT
fnp-3806	3205	5	hu	hu	PROPN
fnp-3806	3205	6	x	x	PROPN
fnp-3806	3205	7	,	,	PUNCT
fnp-3806	3205	8	song	song	ADJ
fnp-3806	3205	9	h	h	PROPN
fnp-3806	3205	10	,	,	PUNCT
fnp-3806	3205	11	yin	yin	PROPN
fnp-3806	3205	12	k	k	PROPN
fnp-3806	3205	13	,	,	PUNCT
fnp-3806	3205	14	et	et	PROPN
fnp-3806	3205	15	al	al	PROPN
fnp-3806	3205	16	.	.	PROPN
fnp-3806	3205	17	matrix	matrix	NOUN
fnp-3806	3205	18	metalloproteinase-9	metalloproteinase-9	NUM
fnp-3806	3205	19	degrades	degrade	VERB
fnp-3806	3205	20	amyloid	amyloid	NOUN
fnp-3806	3205	21	-	-	PUNCT
fnp-3806	3205	22	beta	beta	NOUN
fnp-3806	3205	23	fibrils	fibril	NOUN
fnp-3806	3205	24	in	in	ADP
fnp-3806	3205	25	vitro	vitro	X
fnp-3806	3205	26	and	and	CCONJ
fnp-3806	3205	27	compact	compact	ADJ
fnp-3806	3205	28	plaques	plaque	NOUN
fnp-3806	3205	29	in	in	ADP
fnp-3806	3205	30	situ	situ	NOUN
fnp-3806	3205	31	.	.	PUNCT
fnp-3806	3206	1	j	j	PROPN
fnp-3806	3206	2	biol	biol	PROPN
fnp-3806	3206	3	chem	chem	NOUN
fnp-3806	3206	4	2006;281	2006;281	NUM
fnp-3806	3206	5	:	:	PUNCT
fnp-3806	3206	6	24566	24566	NUM
fnp-3806	3206	7	-	-	SYM
fnp-3806	3206	8	24574	24574	NUM
fnp-3806	3206	9	.	.	PUNCT
fnp-3806	3207	1	https://doi.org/10.1074/jbc.m602440200	https://doi.org/10.1074/jbc.m602440200	X
fnp-3806	3207	2	xiao	xiao	PROPN
fnp-3806	3207	3	q	q	PROPN
fnp-3806	3207	4	,	,	PUNCT
fnp-3806	3207	5	yan	yan	PROPN
fnp-3806	3208	1	p	p	X
fnp-3806	3208	2	,	,	PUNCT
fnp-3806	3208	3	ma	ma	PROPN
fnp-3806	3208	4	x	x	PROPN
fnp-3806	3208	5	,	,	PUNCT
fnp-3806	3208	6	et	et	PROPN
fnp-3806	3208	7	al	al	PROPN
fnp-3806	3208	8	.	.	PUNCT
fnp-3806	3209	1	enhancing	enhance	VERB
fnp-3806	3209	2	astrocytic	astrocytic	ADJ
fnp-3806	3209	3	lysosome	lysosome	NOUN
fnp-3806	3209	4	biogenesis	biogenesis	NOUN
fnp-3806	3209	5	facilitates	facilitate	VERB
fnp-3806	3209	6	aβ	aβ	ADP
fnp-3806	3209	7	clearance	clearance	NOUN
fnp-3806	3209	8	and	and	CCONJ
fnp-3806	3209	9	attenuates	attenuate	VERB
fnp-3806	3209	10	amyloid	amyloid	NOUN
fnp-3806	3209	11	plaque	plaque	NOUN
fnp-3806	3209	12	pathogenesis	pathogenesis	NOUN
fnp-3806	3209	13	.	.	PUNCT
fnp-3806	3210	1	j	j	PROPN
fnp-3806	3210	2	neurosci	neurosci	PROPN
fnp-3806	3210	3	2014;34	2014;34	NUM
fnp-3806	3210	4	:	:	PUNCT
fnp-3806	3210	5	9607	9607	NUM
fnp-3806	3210	6	-	-	SYM
fnp-3806	3210	7	9620	9620	NUM
fnp-3806	3210	8	.	.	PUNCT
fnp-3806	3211	1	https://doi.org/10.1523/jneurosci.3788-13.2014	https://doi.org/10.1523/jneurosci.3788-13.2014	PROPN
fnp-3806	3211	2	basak	basak	PROPN
fnp-3806	3211	3	jm	jm	PROPN
fnp-3806	3211	4	,	,	PUNCT
fnp-3806	3211	5	verghese	verghese	VERB
fnp-3806	3211	6	pb	pb	ADP
fnp-3806	3211	7	,	,	PUNCT
fnp-3806	3211	8	yoon	yoon	PROPN
fnp-3806	3211	9	h	h	PROPN
fnp-3806	3211	10	,	,	PUNCT
fnp-3806	3211	11	et	et	PROPN
fnp-3806	3211	12	al	al	PROPN
fnp-3806	3211	13	.	.	PUNCT
fnp-3806	3211	14	low	low	ADJ
fnp-3806	3211	15	-	-	PUNCT
fnp-3806	3211	16	density	density	NOUN
fnp-3806	3211	17	lipoprotein	lipoprotein	ADJ
fnp-3806	3211	18	receptor	receptor	NOUN
fnp-3806	3211	19	represents	represent	VERB
fnp-3806	3211	20	an	an	DET
fnp-3806	3211	21	apolipoprotein	apolipoprotein	ADJ
fnp-3806	3211	22	e	e	NOUN
fnp-3806	3211	23	-	-	ADJ
fnp-3806	3211	24	independent	independent	ADJ
fnp-3806	3211	25	pathway	pathway	NOUN
fnp-3806	3211	26	of	of	ADP
fnp-3806	3211	27	aβ	aβ	PRON
fnp-3806	3211	28	uptake	uptake	ADJ
fnp-3806	3211	29	and	and	CCONJ
fnp-3806	3211	30	degradation	degradation	NOUN
fnp-3806	3211	31	by	by	ADP
fnp-3806	3211	32	astrocytes	astrocyte	NOUN
fnp-3806	3211	33	.	.	PUNCT
fnp-3806	3212	1	j	j	PROPN
fnp-3806	3212	2	biol	biol	PROPN
fnp-3806	3212	3	chem	chem	NOUN
fnp-3806	3212	4	2012	2012	NUM
fnp-3806	3212	5	;	;	PUNCT
fnp-3806	3212	6	287:13959	287:13959	NUM
fnp-3806	3212	7	-	-	SYM
fnp-3806	3212	8	13971	13971	NUM
fnp-3806	3212	9	.	.	PUNCT
fnp-3806	3213	1	https://doi.org/10.1074/jbc.m111.288746	https://doi.org/10.1074/jbc.m111.288746	PRON
fnp-3806	3213	2	rossner	rossner	NOUN
fnp-3806	3213	3	s	s	PART
fnp-3806	3213	4	,	,	PUNCT
fnp-3806	3213	5	lange	lange	NOUN
fnp-3806	3213	6	-	-	PUNCT
fnp-3806	3213	7	dohna	dohna	NOUN
fnp-3806	3213	8	c	c	NOUN
fnp-3806	3213	9	,	,	PUNCT
fnp-3806	3213	10	zeitschel	zeitschel	PROPN
fnp-3806	3213	11	u	u	PROPN
fnp-3806	3213	12	,	,	PUNCT
fnp-3806	3213	13	et	et	PROPN
fnp-3806	3213	14	al	al	PROPN
fnp-3806	3213	15	.	.	PROPN
fnp-3806	3213	16	alzheimer	alzheimer	PROPN
fnp-3806	3213	17	's	's	PART
fnp-3806	3213	18	disease	disease	NOUN
fnp-3806	3213	19	beta	beta	NOUN
fnp-3806	3213	20	-	-	PUNCT
fnp-3806	3213	21	secretase	secretase	NOUN
fnp-3806	3213	22	bace1	bace1	NOUN
fnp-3806	3213	23	is	be	AUX
fnp-3806	3213	24	not	not	PART
fnp-3806	3213	25	a	a	DET
fnp-3806	3213	26	neuron	neuron	NOUN
fnp-3806	3213	27	-	-	PUNCT
fnp-3806	3213	28	specific	specific	ADJ
fnp-3806	3213	29	enzyme	enzyme	NOUN
fnp-3806	3213	30	.	.	PUNCT
fnp-3806	3214	1	j	j	PROPN
fnp-3806	3214	2	neurochem	neurochem	PROPN
fnp-3806	3214	3	2005;92	2005;92	NUM
fnp-3806	3214	4	:	:	PUNCT
fnp-3806	3214	5	226	226	NUM
fnp-3806	3214	6	-	-	SYM
fnp-3806	3214	7	234	234	NUM
fnp-3806	3214	8	.	.	PUNCT
fnp-3806	3215	1	https://doi.org/10.1111/j.1471-4159.2004.02857.x	https://doi.org/10.1111/j.1471-4159.2004.02857.x	PROPN
fnp-3806	3215	2	zhao	zhao	PROPN
fnp-3806	3215	3	j	j	PROPN
fnp-3806	3215	4	,	,	PUNCT
fnp-3806	3215	5	o'connor	o'connor	PROPN
fnp-3806	3215	6	t	t	PROPN
fnp-3806	3215	7	,	,	PUNCT
fnp-3806	3215	8	vassar	vassar	PROPN
fnp-3806	3215	9	r.	r.	PROPN
fnp-3806	3215	10	the	the	DET
fnp-3806	3215	11	contribution	contribution	NOUN
fnp-3806	3215	12	of	of	ADP
fnp-3806	3215	13	activated	activate	VERB
fnp-3806	3215	14	astrocytes	astrocyte	NOUN
fnp-3806	3215	15	to	to	ADP
fnp-3806	3215	16	aβ	aβ	NOUN
fnp-3806	3215	17	production	production	NOUN
fnp-3806	3215	18	:	:	PUNCT
fnp-3806	3215	19	implications	implication	NOUN
fnp-3806	3215	20	for	for	ADP
fnp-3806	3215	21	alzheimer	alzheimer	PROPN
fnp-3806	3215	22	's	's	PART
fnp-3806	3215	23	disease	disease	NOUN
fnp-3806	3215	24	pathogenesis	pathogenesis	NOUN
fnp-3806	3215	25	.	.	PUNCT
fnp-3806	3216	1	j	j	PROPN
fnp-3806	3216	2	neuroinflammation	neuroinflammation	PROPN
fnp-3806	3216	3	2011;8	2011;8	NOUN
fnp-3806	3216	4	:	:	PUNCT
fnp-3806	3217	1	150	150	NUM
fnp-3806	3217	2	.	.	PUNCT
fnp-3806	3218	1	https://doi.org/10.1186/1742-2094-8-150	https://doi.org/10.1186/1742-2094-8-150	ADP
fnp-3806	3218	2	sanchez	sanchez	PROPN
fnp-3806	3218	3	-	-	PUNCT
fnp-3806	3218	4	mico	mico	PROPN
fnp-3806	3218	5	mv	mv	PROPN
fnp-3806	3218	6	,	,	PUNCT
fnp-3806	3218	7	jimenez	jimenez	PROPN
fnp-3806	3218	8	s	s	PROPN
fnp-3806	3218	9	,	,	PUNCT
fnp-3806	3218	10	gomez	gomez	NOUN
fnp-3806	3218	11	-	-	PUNCT
fnp-3806	3218	12	arboledas	arboledas	PROPN
fnp-3806	3218	13	a	a	PROPN
fnp-3806	3218	14	,	,	PUNCT
fnp-3806	3218	15	et	et	PROPN
fnp-3806	3218	16	al	al	PROPN
fnp-3806	3218	17	.	.	PUNCT
fnp-3806	3218	18	amyloid	amyloid	PROPN
fnp-3806	3218	19	beta	beta	PROPN
fnp-3806	3218	20	impairs	impair	VERB
fnp-3806	3218	21	phagocytosis	phagocytosis	NOUN
fnp-3806	3218	22	of	of	ADP
fnp-3806	3218	23	dystrophic	dystrophic	ADJ
fnp-3806	3218	24	synapses	synapsis	NOUN
fnp-3806	3218	25	by	by	ADP
fnp-3806	3218	26	astrocytes	astrocyte	NOUN
fnp-3806	3218	27	in	in	ADP
fnp-3806	3218	28	alzheier	alzheier	NOUN
fnp-3806	3218	29	’s	’s	PART
fnp-3806	3218	30	disease	disease	NOUN
fnp-3806	3218	31	.	.	PUNCT
fnp-3806	3219	1	glia	glia	PROPN
fnp-3806	3219	2	2021;69:997	2021;69:997	NOUN
fnp-3806	3219	3	-	-	SYM
fnp-3806	3219	4	1011	1011	NUM
fnp-3806	3219	5	.	.	PUNCT
fnp-3806	3220	1	https://doi.org/10.1002/glia.23943	https://doi.org/10.1002/glia.23943	PROPN
fnp-3806	3220	2	grolla	grolla	PROPN
fnp-3806	3220	3	aa	aa	PROPN
fnp-3806	3220	4	,	,	PUNCT
fnp-3806	3220	5	sim	sim	PROPN
fnp-3806	3220	6	ja	ja	PROPN
fnp-3806	3220	7	,	,	PUNCT
fnp-3806	3220	8	lim	lim	PROPN
fnp-3806	3220	9	d	d	PROPN
fnp-3806	3220	10	,	,	PUNCT
fnp-3806	3220	11	et	et	PROPN
fnp-3806	3220	12	al	al	PROPN
fnp-3806	3220	13	.	.	PUNCT
fnp-3806	3220	14	amyloid	amyloid	PROPN
fnp-3806	3220	15	-	-	PUNCT
fnp-3806	3220	16	β	β	PROPN
fnp-3806	3220	17	and	and	CCONJ
fnp-3806	3220	18	alzheimer	alzheimer	PROPN
fnp-3806	3220	19	's	's	PART
fnp-3806	3220	20	disease	disease	NOUN
fnp-3806	3220	21	type	type	NOUN
fnp-3806	3220	22	pathology	pathology	NOUN
fnp-3806	3220	23	differentially	differentially	ADV
fnp-3806	3220	24	affects	affect	VERB
fnp-3806	3220	25	the	the	DET
fnp-3806	3220	26	calcium	calcium	NOUN
fnp-3806	3220	27	signalling	signal	VERB
fnp-3806	3220	28	toolkit	toolkit	NOUN
fnp-3806	3220	29	in	in	ADP
fnp-3806	3220	30	astrocytes	astrocyte	NOUN
fnp-3806	3220	31	from	from	ADP
fnp-3806	3220	32	different	different	ADJ
fnp-3806	3220	33	brain	brain	NOUN
fnp-3806	3220	34	regions	region	NOUN
fnp-3806	3220	35	.	.	PUNCT
fnp-3806	3221	1	cell	cell	NOUN
fnp-3806	3221	2	death	death	NOUN
fnp-3806	3221	3	dis	dis	PROPN
fnp-3806	3221	4	2013	2013	NUM
fnp-3806	3221	5	;	;	PUNCT
fnp-3806	3221	6	4	4	NUM
fnp-3806	3221	7	:	:	PUNCT
fnp-3806	3221	8	e623	e623	NUM
fnp-3806	3221	9	.	.	PUNCT
fnp-3806	3222	1	https://doi.org/10.1038/cddis.2013.145	https://doi.org/10.1038/cddis.2013.145	PROPN
fnp-3806	3222	2	lim	lim	PROPN
fnp-3806	3222	3	d	d	PROPN
fnp-3806	3222	4	,	,	PUNCT
fnp-3806	3222	5	ronco	ronco	PROPN
fnp-3806	3222	6	v	v	PROPN
fnp-3806	3222	7	,	,	PUNCT
fnp-3806	3222	8	grolla	grolla	NOUN
fnp-3806	3222	9	aa	aa	PROPN
fnp-3806	3222	10	,	,	PUNCT
fnp-3806	3222	11	et	et	PROPN
fnp-3806	3222	12	al	al	PROPN
fnp-3806	3222	13	.	.	PUNCT
fnp-3806	3223	1	glial	glial	ADJ
fnp-3806	3223	2	calcium	calcium	NOUN
fnp-3806	3223	3	signalling	signal	VERB
fnp-3806	3223	4	in	in	ADP
fnp-3806	3223	5	alzheimer	alzheimer	PROPN
fnp-3806	3223	6	's	's	PART
fnp-3806	3223	7	disease	disease	NOUN
fnp-3806	3223	8	.	.	PUNCT
fnp-3806	3224	1	rev	rev	PROPN
fnp-3806	3224	2	physiol	physiol	PROPN
fnp-3806	3224	3	biochem	biochem	PROPN
fnp-3806	3224	4	pharmacol	pharmacol	PROPN
fnp-3806	3224	5	2014;167	2014;167	NUM
fnp-3806	3224	6	:	:	PUNCT
fnp-3806	3224	7	45	45	NUM
fnp-3806	3224	8	-	-	SYM
fnp-3806	3224	9	65	65	NUM
fnp-3806	3224	10	.	.	PUNCT
fnp-3806	3225	1	https://doi.org/10.1007/112_2014_19	https://doi.org/10.1007/112_2014_19	PROPN
fnp-3806	3225	2	verkhratsky	verkhratsky	PROPN
fnp-3806	3225	3	a	a	PRON
fnp-3806	3225	4	,	,	PUNCT
fnp-3806	3225	5	rodríguez	rodríguez	NOUN
fnp-3806	3225	6	-	-	PUNCT
fnp-3806	3225	7	arellano	arellano	PROPN
fnp-3806	3225	8	jj	jj	PROPN
fnp-3806	3225	9	,	,	PUNCT
fnp-3806	3225	10	parpura	parpura	NOUN
fnp-3806	3225	11	v	v	NOUN
fnp-3806	3225	12	,	,	PUNCT
fnp-3806	3225	13	et	et	PROPN
fnp-3806	3225	14	al	al	PROPN
fnp-3806	3225	15	.	.	PROPN
fnp-3806	3225	16	astroglial	astroglial	ADJ
fnp-3806	3225	17	calcium	calcium	NOUN
fnp-3806	3225	18	signalling	signal	VERB
fnp-3806	3225	19	in	in	ADP
fnp-3806	3225	20	alzheimer	alzheimer	PROPN
fnp-3806	3225	21	's	's	PART
fnp-3806	3225	22	disease	disease	NOUN
fnp-3806	3225	23	.	.	PUNCT
fnp-3806	3226	1	biochem	biochem	PROPN
fnp-3806	3226	2	biophys	biophys	PROPN
fnp-3806	3226	3	res	res	PROPN
fnp-3806	3226	4	commun	commun	PROPN
fnp-3806	3226	5	2017;483:1005	2017;483:1005	PROPN
fnp-3806	3226	6	-	-	SYM
fnp-3806	3226	7	1012	1012	NUM
fnp-3806	3226	8	.	.	PUNCT
fnp-3806	3227	1	https://doi.org/10.1016/j.bbrc.2016.08.088	https://doi.org/10.1016/j.bbrc.2016.08.088	PROPN
fnp-3806	3227	2	talantova	talantova	NOUN
fnp-3806	3227	3	m	m	PROPN
fnp-3806	3227	4	,	,	PUNCT
fnp-3806	3227	5	sanz	sanz	PROPN
fnp-3806	3227	6	-	-	PUNCT
fnp-3806	3227	7	blasco	blasco	PROPN
fnp-3806	3227	8	s	s	PROPN
fnp-3806	3227	9	,	,	PUNCT
fnp-3806	3227	10	zhang	zhang	PROPN
fnp-3806	3227	11	x	x	PROPN
fnp-3806	3227	12	,	,	PUNCT
fnp-3806	3227	13	et	et	PROPN
fnp-3806	3227	14	al	al	PROPN
fnp-3806	3227	15	.	.	PUNCT
fnp-3806	3228	1	aβ	aβ	PRON
fnp-3806	3228	2	induces	induce	VERB
fnp-3806	3228	3	astrocytic	astrocytic	ADJ
fnp-3806	3228	4	glutamate	glutamate	NOUN
fnp-3806	3228	5	release	release	NOUN
fnp-3806	3228	6	,	,	PUNCT
fnp-3806	3228	7	extrasynaptic	extrasynaptic	ADJ
fnp-3806	3228	8	nmda	nmda	ADJ
fnp-3806	3228	9	receptor	receptor	NOUN
fnp-3806	3228	10	activation	activation	NOUN
fnp-3806	3228	11	,	,	PUNCT
fnp-3806	3228	12	and	and	CCONJ
fnp-3806	3228	13	synaptic	synaptic	ADJ
fnp-3806	3228	14	loss	loss	NOUN
fnp-3806	3228	15	.	.	PUNCT
fnp-3806	3229	1	proc	proc	PROPN
fnp-3806	3229	2	natl	natl	PROPN
fnp-3806	3229	3	acad	acad	PROPN
fnp-3806	3229	4	sci	sci	PROPN
fnp-3806	3229	5	usa	usa	PROPN
fnp-3806	3229	6	2013;110	2013;110	PROPN
fnp-3806	3229	7	:	:	PUNCT
fnp-3806	3229	8	e2518	e2518	PROPN
fnp-3806	3229	9	-	-	PUNCT
fnp-3806	3229	10	2527	2527	NUM
fnp-3806	3229	11	.	.	PUNCT
fnp-3806	3230	1	https://doi.org/10.1073/pnas.1306832110	https://doi.org/10.1073/pnas.1306832110	PROPN
fnp-3806	3230	2	lim	lim	PROPN
fnp-3806	3230	3	d	d	PROPN
fnp-3806	3230	4	,	,	PUNCT
fnp-3806	3230	5	iyer	iyer	PROPN
fnp-3806	3230	6	a	a	PROPN
fnp-3806	3230	7	,	,	PUNCT
fnp-3806	3230	8	ronco	ronco	PROPN
fnp-3806	3230	9	v	v	PROPN
fnp-3806	3230	10	,	,	PUNCT
fnp-3806	3230	11	et	et	PROPN
fnp-3806	3230	12	al	al	PROPN
fnp-3806	3230	13	.	.	PUNCT
fnp-3806	3231	1	amyloid	amyloid	PROPN
fnp-3806	3231	2	beta	beta	NOUN
fnp-3806	3231	3	deregulates	deregulate	VERB
fnp-3806	3231	4	astroglial	astroglial	ADJ
fnp-3806	3231	5	mglur5	mglur5	NOUN
fnp-3806	3231	6	-	-	PUNCT
fnp-3806	3231	7	mediated	mediate	VERB
fnp-3806	3231	8	calcium	calcium	NOUN
fnp-3806	3231	9	signaling	signal	VERB
fnp-3806	3231	10	via	via	ADP
fnp-3806	3231	11	calcineurin	calcineurin	NOUN
fnp-3806	3231	12	and	and	CCONJ
fnp-3806	3231	13	nf	nf	PROPN
fnp-3806	3231	14	-	-	PUNCT
fnp-3806	3231	15	kb	kb	PROPN
fnp-3806	3231	16	.	.	PUNCT
fnp-3806	3231	17	glia	glia	PROPN
fnp-3806	3231	18	2013;61	2013;61	NUM
fnp-3806	3231	19	:	:	PUNCT
fnp-3806	3231	20	1134	1134	NUM
fnp-3806	3231	21	-	-	SYM
fnp-3806	3231	22	1145	1145	NUM
fnp-3806	3231	23	.	.	PUNCT
fnp-3806	3232	1	https://doi.org/10.1002/glia.22502	https://doi.org/10.1002/glia.22502	VERB
fnp-3806	3232	2	verkhratsky	verkhratsky	PROPN
fnp-3806	3232	3	a	a	DET
fnp-3806	3232	4	,	,	PUNCT
fnp-3806	3232	5	chvátal	chvátal	ADJ
fnp-3806	3232	6	a.	a.	NOUN
fnp-3806	3232	7	nmda	nmda	ADJ
fnp-3806	3232	8	receptors	receptor	NOUN
fnp-3806	3232	9	in	in	ADP
fnp-3806	3232	10	astrocytes	astrocyte	NOUN
fnp-3806	3232	11	.	.	PUNCT
fnp-3806	3233	1	neurochem	neurochem	PROPN
fnp-3806	3233	2	res	re	VERB
fnp-3806	3233	3	2020;45:122	2020;45:122	NUM
fnp-3806	3233	4	-	-	SYM
fnp-3806	3233	5	133	133	NUM
fnp-3806	3233	6	.	.	PUNCT
fnp-3806	3234	1	https://doi.org/10.1007/s11064-019-02750-3	https://doi.org/10.1007/s11064-019-02750-3	NUM
fnp-3806	3234	2	lauderback	lauderback	NOUN
fnp-3806	3234	3	cm	cm	PROPN
fnp-3806	3234	4	,	,	PUNCT
fnp-3806	3234	5	hackett	hackett	PROPN
fnp-3806	3234	6	jm	jm	PROPN
fnp-3806	3234	7	,	,	PUNCT
fnp-3806	3234	8	huang	huang	PROPN
fnp-3806	3234	9	ff	ff	PROPN
fnp-3806	3234	10	,	,	PUNCT
fnp-3806	3234	11	et	et	PROPN
fnp-3806	3234	12	al	al	PROPN
fnp-3806	3234	13	.	.	PUNCT
fnp-3806	3235	1	the	the	DET
fnp-3806	3235	2	glial	glial	ADJ
fnp-3806	3235	3	glutamate	glutamate	NOUN
fnp-3806	3235	4	transporter	transporter	NOUN
fnp-3806	3235	5	,	,	PUNCT
fnp-3806	3235	6	glt-1	glt-1	NUM
fnp-3806	3235	7	,	,	PUNCT
fnp-3806	3235	8	is	be	AUX
fnp-3806	3235	9	oxidatively	oxidatively	ADV
fnp-3806	3235	10	modified	modify	VERB
fnp-3806	3235	11	by	by	ADP
fnp-3806	3235	12	4	4	NUM
fnp-3806	3235	13	-	-	PUNCT
fnp-3806	3235	14	hydroxy-2	hydroxy-2	NOUN
fnp-3806	3235	15	-	-	PUNCT
fnp-3806	3235	16	nonenal	nonenal	NOUN
fnp-3806	3235	17	in	in	ADP
fnp-3806	3235	18	the	the	DET
fnp-3806	3235	19	alzheimer	alzheimer	PROPN
fnp-3806	3235	20	's	's	PART
fnp-3806	3235	21	disease	disease	NOUN
fnp-3806	3235	22	brain	brain	NOUN
fnp-3806	3235	23	:	:	PUNCT
fnp-3806	3235	24	the	the	DET
fnp-3806	3235	25	role	role	NOUN
fnp-3806	3235	26	of	of	ADP
fnp-3806	3235	27	abeta1	abeta1	PROPN
fnp-3806	3235	28	-	-	PUNCT
fnp-3806	3235	29	42	42	NUM
fnp-3806	3235	30	.	.	PUNCT
fnp-3806	3236	1	j	j	PROPN
fnp-3806	3236	2	neurochem	neurochem	PROPN
fnp-3806	3236	3	2001;78	2001;78	NUM
fnp-3806	3236	4	:	:	PUNCT
fnp-3806	3236	5	413	413	NUM
fnp-3806	3236	6	-	-	SYM
fnp-3806	3236	7	416	416	NUM
fnp-3806	3236	8	.	.	PUNCT
fnp-3806	3237	1	https://doi.org/10.1046/j.1471-4159.2001.00451.x	https://doi.org/10.1046/j.1471-4159.2001.00451.x	NOUN
fnp-3806	3237	2	scott	scott	PROPN
fnp-3806	3237	3	ha	ha	INTJ
fnp-3806	3237	4	,	,	PUNCT
fnp-3806	3237	5	gebhardt	gebhardt	PROPN
fnp-3806	3237	6	fm	fm	PROPN
fnp-3806	3237	7	,	,	PUNCT
fnp-3806	3237	8	mitrovic	mitrovic	ADJ
fnp-3806	3237	9	ad	ad	NOUN
fnp-3806	3237	10	,	,	PUNCT
fnp-3806	3237	11	et	et	PROPN
fnp-3806	3237	12	al	al	PROPN
fnp-3806	3237	13	.	.	PROPN
fnp-3806	3238	1	glutamate	glutamate	ADJ
fnp-3806	3238	2	transporter	transporter	NOUN
fnp-3806	3238	3	variants	variant	NOUN
fnp-3806	3238	4	reduce	reduce	VERB
fnp-3806	3238	5	glutamate	glutamate	ADJ
fnp-3806	3238	6	uptake	uptake	NOUN
fnp-3806	3238	7	in	in	ADP
fnp-3806	3238	8	alzheimer	alzheimer	PROPN
fnp-3806	3238	9	's	's	PART
fnp-3806	3238	10	disease	disease	NOUN
fnp-3806	3238	11	.	.	PUNCT
fnp-3806	3239	1	neurobiol	neurobiol	PROPN
fnp-3806	3239	2	aging	age	VERB
fnp-3806	3239	3	2011;32	2011;32	NUM
fnp-3806	3239	4	:	:	PUNCT
fnp-3806	3239	5	553.e1	553.e1	NUM
fnp-3806	3239	6	-	-	SYM
fnp-3806	3239	7	11	11	NUM
fnp-3806	3239	8	.	.	PUNCT
fnp-3806	3240	1	https://doi.org/10.1016/j.neurobiolaging	https://doi.org/10.1016/j.neurobiolage	VERB
fnp-3806	3240	2	2010.03.008	2010.03.008	NOUN
fnp-3806	3240	3	.	.	PUNCT
fnp-3806	3241	1	woltjer	woltjer	PROPN
fnp-3806	3241	2	rl	rl	PROPN
fnp-3806	3241	3	,	,	PUNCT
fnp-3806	3241	4	duerson	duerson	PROPN
fnp-3806	3241	5	k	k	PROPN
fnp-3806	3241	6	,	,	PUNCT
fnp-3806	3241	7	fullmer	fullmer	PROPN
fnp-3806	3241	8	jm	jm	PROPN
fnp-3806	3241	9	,	,	PUNCT
fnp-3806	3241	10	et	et	PROPN
fnp-3806	3241	11	al	al	PROPN
fnp-3806	3241	12	.	.	PROPN
fnp-3806	3241	13	aberrant	aberrant	ADJ
fnp-3806	3241	14	detergent	detergent	NOUN
fnp-3806	3241	15	-	-	PUNCT
fnp-3806	3241	16	insoluble	insoluble	ADJ
fnp-3806	3241	17	excitatory	excitatory	NOUN
fnp-3806	3241	18	amino	amino	NOUN
fnp-3806	3241	19	acid	acid	NOUN
fnp-3806	3241	20	transporter	transporter	NOUN
fnp-3806	3241	21	2	2	NUM
fnp-3806	3241	22	accumulates	accumulate	VERB
fnp-3806	3241	23	in	in	ADP
fnp-3806	3241	24	alzheimer	alzheimer	PROPN
fnp-3806	3241	25	disease	disease	NOUN
fnp-3806	3241	26	.	.	PUNCT
fnp-3806	3242	1	j	j	PROPN
fnp-3806	3242	2	neuropathol	neuropathol	PROPN
fnp-3806	3242	3	exp	exp	PROPN
fnp-3806	3242	4	neurol	neurol	PROPN
fnp-3806	3242	5	2010;69	2010;69	NUM
fnp-3806	3242	6	:	:	PUNCT
fnp-3806	3242	7	667	667	NUM
fnp-3806	3242	8	-	-	SYM
fnp-3806	3242	9	676	676	NUM
fnp-3806	3242	10	.	.	PUNCT
fnp-3806	3243	1	https://doi.org/10.1097/nen.0b013e3181e24adb	https://doi.org/10.1097/nen.0b013e3181e24adb	PROPN
fnp-3806	3243	2	masliah	masliah	PROPN
fnp-3806	3243	3	e	e	PROPN
fnp-3806	3243	4	,	,	PUNCT
fnp-3806	3243	5	alford	alford	PROPN
fnp-3806	3243	6	m	m	PROPN
fnp-3806	3243	7	,	,	PUNCT
fnp-3806	3243	8	deteresa	deteresa	PROPN
fnp-3806	3243	9	r	r	NOUN
fnp-3806	3243	10	,	,	PUNCT
fnp-3806	3243	11	et	et	PROPN
fnp-3806	3243	12	al	al	PROPN
fnp-3806	3243	13	.	.	PROPN
fnp-3806	3243	14	deficient	deficient	ADJ
fnp-3806	3243	15	glutamate	glutamate	NOUN
fnp-3806	3243	16	transport	transport	NOUN
fnp-3806	3243	17	is	be	AUX
fnp-3806	3243	18	associated	associate	VERB
fnp-3806	3243	19	with	with	ADP
fnp-3806	3243	20	neurodegeneration	neurodegeneration	NOUN
fnp-3806	3243	21	in	in	ADP
fnp-3806	3243	22	alzheimer	alzheimer	PROPN
fnp-3806	3243	23	’s	’s	PART
fnp-3806	3243	24	disease	disease	NOUN
fnp-3806	3243	25	.	.	PUNCT
fnp-3806	3244	1	ann	ann	PROPN
fnp-3806	3244	2	neurol	neurol	PROPN
fnp-3806	3244	3	1996;40	1996;40	PROPN
fnp-3806	3244	4	:	:	PUNCT
fnp-3806	3244	5	759	759	NUM
fnp-3806	3244	6	-	-	SYM
fnp-3806	3244	7	766	766	NUM
fnp-3806	3244	8	.	.	PUNCT
fnp-3806	3245	1	https://doi.org/10.1002/ana.410400512	https://doi.org/10.1002/ana.410400512	PROPN
fnp-3806	3245	2	abdul	abdul	PROPN
fnp-3806	3245	3	hm	hm	PROPN
fnp-3806	3245	4	,	,	PUNCT
fnp-3806	3245	5	sama	sama	PROPN
fnp-3806	3245	6	ma	ma	PROPN
fnp-3806	3245	7	,	,	PUNCT
fnp-3806	3245	8	furman	furman	PROPN
fnp-3806	3245	9	jl	jl	PROPN
fnp-3806	3245	10	,	,	PUNCT
fnp-3806	3245	11	et	et	PROPN
fnp-3806	3245	12	al	al	PROPN
fnp-3806	3245	13	.	.	PROPN
fnp-3806	3245	14	cognitive	cognitive	ADJ
fnp-3806	3245	15	decline	decline	NOUN
fnp-3806	3245	16	in	in	ADP
fnp-3806	3245	17	alzheimer	alzheimer	PROPN
fnp-3806	3245	18	’s	’s	PART
fnp-3806	3245	19	disease	disease	NOUN
fnp-3806	3245	20	is	be	AUX
fnp-3806	3245	21	associated	associate	VERB
fnp-3806	3245	22	with	with	ADP
fnp-3806	3245	23	selective	selective	ADJ
fnp-3806	3245	24	changes	change	NOUN
fnp-3806	3245	25	in	in	ADP
fnp-3806	3245	26	calcineurin	calcineurin	ADJ
fnp-3806	3245	27	/	/	SYM
fnp-3806	3245	28	nfat	nfat	NOUN
fnp-3806	3245	29	signaling	signal	VERB
fnp-3806	3245	30	.	.	PUNCT
fnp-3806	3246	1	j	j	PROPN
fnp-3806	3246	2	neurosci	neurosci	PROPN
fnp-3806	3246	3	2009;29:12957	2009;29:12957	PROPN
fnp-3806	3246	4	-	-	SYM
fnp-3806	3246	5	12969	12969	NUM
fnp-3806	3246	6	.	.	PUNCT
fnp-3806	3247	1	https://doi.org/10.1523/jneurosci.1064-09.2009	https://doi.org/10.1523/jneurosci.1064-09.2009	PROPN
fnp-3806	3247	2	orre	orre	PROPN
fnp-3806	3247	3	m	m	PROPN
fnp-3806	3247	4	,	,	PUNCT
fnp-3806	3247	5	kamphuis	kamphuis	PROPN
fnp-3806	3247	6	w	w	PROPN
fnp-3806	3247	7	,	,	PUNCT
fnp-3806	3247	8	osborn	osborn	PROPN
fnp-3806	3247	9	lm	lm	PROPN
fnp-3806	3247	10	,	,	PUNCT
fnp-3806	3247	11	jansen	jansen	PROPN
fnp-3806	3247	12	ah	ah	INTJ
fnp-3806	3247	13	,	,	PUNCT
fnp-3806	3247	14	et	et	PROPN
fnp-3806	3247	15	al	al	PROPN
fnp-3806	3247	16	.	.	PUNCT
fnp-3806	3247	17	isolation	isolation	NOUN
fnp-3806	3247	18	of	of	ADP
fnp-3806	3247	19	glia	glia	NOUN
fnp-3806	3247	20	from	from	ADP
fnp-3806	3247	21	alzheimer	alzheimer	PROPN
fnp-3806	3247	22	's	's	PART
fnp-3806	3247	23	mice	mouse	NOUN
fnp-3806	3247	24	reveals	reveal	VERB
fnp-3806	3247	25	inflammation	inflammation	NOUN
fnp-3806	3247	26	and	and	CCONJ
fnp-3806	3247	27	dysfunction	dysfunction	NOUN
fnp-3806	3247	28	.	.	PUNCT
fnp-3806	3248	1	neurobiol	neurobiol	ADJ
fnp-3806	3248	2	aging	age	VERB
fnp-3806	3248	3	2014;35	2014;35	NOUN
fnp-3806	3248	4	:	:	PUNCT
fnp-3806	3248	5	2746	2746	NUM
fnp-3806	3248	6	-	-	SYM
fnp-3806	3248	7	2760	2760	NUM
fnp-3806	3248	8	.	.	PUNCT
fnp-3806	3249	1	https://doi.org/10.1016/j.neurobiolaging	https://doi.org/10.1016/j.neurobiolage	VERB
fnp-3806	3249	2	2014.06.004	2014.06.004	NOUN
fnp-3806	3249	3	.	.	PUNCT
fnp-3806	3250	1	dansokho	dansokho	PROPN
fnp-3806	3250	2	c	c	PROPN
fnp-3806	3250	3	,	,	PUNCT
fnp-3806	3250	4	heneka	heneka	PROPN
fnp-3806	3250	5	mt	mt	PROPN
fnp-3806	3250	6	.	.	PUNCT
fnp-3806	3251	1	neuroinflammatory	neuroinflammatory	PROPN
fnp-3806	3251	2	responses	response	NOUN
fnp-3806	3251	3	in	in	ADP
fnp-3806	3251	4	alzheimer	alzheimer	PROPN
fnp-3806	3251	5	’s	’s	PART
fnp-3806	3251	6	disease	disease	NOUN
fnp-3806	3251	7	.	.	PUNCT
fnp-3806	3252	1	j	j	PROPN
fnp-3806	3252	2	neural	neural	ADJ
fnp-3806	3252	3	transm	transm	PROPN
fnp-3806	3252	4	2018;125:771	2018;125:771	NUM
fnp-3806	3252	5	-	-	SYM
fnp-3806	3252	6	779	779	NUM
fnp-3806	3252	7	.	.	PUNCT
fnp-3806	3253	1	https://doi.org/10.1007/s00702-017-1831-7	https://doi.org/10.1007/s00702-017-1831-7	NUM
fnp-3806	3253	2	tomimoto	tomimoto	NOUN
fnp-3806	3253	3	h	h	NOUN
fnp-3806	3253	4	,	,	PUNCT
fnp-3806	3253	5	akiguchi	akiguchi	PROPN
fnp-3806	3253	6	i	i	PRON
fnp-3806	3253	7	,	,	PUNCT
fnp-3806	3253	8	wakita	wakita	PROPN
fnp-3806	3253	9	h	h	PROPN
fnp-3806	3253	10	,	,	PUNCT
fnp-3806	3253	11	et	et	PROPN
fnp-3806	3253	12	al	al	PROPN
fnp-3806	3253	13	.	.	PROPN
fnp-3806	3254	1	regressive	regressive	ADJ
fnp-3806	3254	2	changes	change	NOUN
fnp-3806	3254	3	of	of	ADP
fnp-3806	3254	4	astroglia	astroglia	PROPN
fnp-3806	3254	5	in	in	ADP
fnp-3806	3254	6	white	white	ADJ
fnp-3806	3254	7	matter	matter	NOUN
fnp-3806	3254	8	lesions	lesion	NOUN
fnp-3806	3254	9	in	in	ADP
fnp-3806	3254	10	cerebrovascular	cerebrovascular	ADJ
fnp-3806	3254	11	disease	disease	NOUN
fnp-3806	3254	12	and	and	CCONJ
fnp-3806	3254	13	alzheimer	alzheimer	PROPN
fnp-3806	3254	14	’s	’s	PART
fnp-3806	3254	15	disease	disease	NOUN
fnp-3806	3254	16	patients	patient	NOUN
fnp-3806	3254	17	.	.	PUNCT
fnp-3806	3255	1	acta	acta	PROPN
fnp-3806	3255	2	neuropathol	neuropathol	PROPN
fnp-3806	3255	3	1997;94:146	1997;94:146	PROPN
fnp-3806	3255	4	-	-	SYM
fnp-3806	3255	5	152	152	NUM
fnp-3806	3255	6	.	.	PUNCT
fnp-3806	3256	1	https://doi.org/10.1007/s004010050686	https://doi.org/10.1007/s004010050686	NUM
fnp-3806	3256	2	schipper	schipper	PROPN
fnp-3806	3256	3	hm	hm	PROPN
fnp-3806	3256	4	,	,	PUNCT
fnp-3806	3256	5	bennett	bennett	PROPN
fnp-3806	3256	6	da	da	PROPN
fnp-3806	3256	7	,	,	PUNCT
fnp-3806	3256	8	liberman	liberman	PROPN
fnp-3806	3256	9	a	a	PROPN
fnp-3806	3256	10	,	,	PUNCT
fnp-3806	3256	11	et	et	PROPN
fnp-3806	3256	12	al	al	PROPN
fnp-3806	3256	13	.	.	PUNCT
fnp-3806	3256	14	glial	glial	ADJ
fnp-3806	3256	15	heme	heme	NOUN
fnp-3806	3256	16	oxygenase-1	oxygenase-1	NOUN
fnp-3806	3256	17	expression	expression	NOUN
fnp-3806	3256	18	in	in	ADP
fnp-3806	3256	19	alzheimer	alzheimer	PROPN
fnp-3806	3256	20	disease	disease	NOUN
fnp-3806	3256	21	and	and	CCONJ
fnp-3806	3256	22	mild	mild	ADJ
fnp-3806	3256	23	cognitive	cognitive	ADJ
fnp-3806	3256	24	impairment	impairment	NOUN
fnp-3806	3256	25	.	.	PUNCT
fnp-3806	3257	1	neurobiol	neurobiol	PROPN
fnp-3806	3257	2	aging	age	VERB
fnp-3806	3257	3	2006;27:252	2006;27:252	NUM
fnp-3806	3257	4	-	-	SYM
fnp-3806	3257	5	261	261	NUM
fnp-3806	3257	6	.	.	PUNCT
fnp-3806	3258	1	https://doi.org/10.1016/j.neurobiolaging.2005.01.016	https://doi.org/10.1016/j.neurobiolaging.2005.01.016	PROPN
fnp-3806	3258	2	assaraf	assaraf	PROPN
fnp-3806	3258	3	mi	mi	PROPN
fnp-3806	3258	4	,	,	PUNCT
fnp-3806	3258	5	diaz	diaz	PROPN
fnp-3806	3258	6	z	z	PROPN
fnp-3806	3258	7	,	,	PUNCT
fnp-3806	3258	8	liberman	liberman	PROPN
fnp-3806	3258	9	a	a	PROPN
fnp-3806	3258	10	,	,	PUNCT
fnp-3806	3258	11	et	et	PROPN
fnp-3806	3258	12	al	al	PROPN
fnp-3806	3258	13	.	.	PROPN
fnp-3806	3258	14	brain	brain	NOUN
fnp-3806	3258	15	erythropoietin	erythropoietin	NOUN
fnp-3806	3258	16	receptor	receptor	NOUN
fnp-3806	3258	17	expression	expression	NOUN
fnp-3806	3258	18	in	in	ADP
fnp-3806	3258	19	alzheimer	alzheimer	PROPN
fnp-3806	3258	20	disease	disease	NOUN
fnp-3806	3258	21	and	and	CCONJ
fnp-3806	3258	22	mild	mild	ADJ
fnp-3806	3258	23	cognitive	cognitive	ADJ
fnp-3806	3258	24	impairment	impairment	NOUN
fnp-3806	3258	25	.	.	PUNCT
fnp-3806	3259	1	j	j	PROPN
fnp-3806	3259	2	neuropathol	neuropathol	PROPN
fnp-3806	3259	3	exp	exp	PROPN
fnp-3806	3259	4	neurol	neurol	PROPN
fnp-3806	3259	5	2007;66:389	2007;66:389	PROPN
fnp-3806	3259	6	-	-	SYM
fnp-3806	3259	7	398	398	NUM
fnp-3806	3259	8	.	.	PUNCT
fnp-3806	3260	1	https://doi.org/10.1097/nen.0b013e3180517b28	https://doi.org/10.1097/nen.0b013e3180517b28	PROPN
fnp-3806	3260	2	owen	owen	PROPN
fnp-3806	3260	3	jb	jb	PROPN
fnp-3806	3260	4	,	,	PUNCT
fnp-3806	3260	5	di	di	PROPN
fnp-3806	3260	6	domenico	domenico	PROPN
fnp-3806	3260	7	f	f	PROPN
fnp-3806	3260	8	,	,	PUNCT
fnp-3806	3260	9	sultana	sultana	NOUN
fnp-3806	3260	10	r	r	NOUN
fnp-3806	3260	11	,	,	PUNCT
fnp-3806	3260	12	et	et	PROPN
fnp-3806	3260	13	al	al	PROPN
fnp-3806	3260	14	.	.	PUNCT
fnp-3806	3261	1	proteomics	proteomic	NOUN
fnp-3806	3261	2	-	-	PUNCT
fnp-3806	3261	3	determined	determine	VERB
fnp-3806	3261	4	differences	difference	NOUN
fnp-3806	3261	5	in	in	ADP
fnp-3806	3261	6	the	the	DET
fnp-3806	3261	7	concanavalin	concanavalin	NOUN
fnp-3806	3261	8	-	-	PUNCT
fnp-3806	3261	9	a	a	PRON
fnp-3806	3261	10	-	-	PUNCT
fnp-3806	3261	11	fractionated	fractionate	VERB
fnp-3806	3261	12	proteome	proteome	NOUN
fnp-3806	3261	13	of	of	ADP
fnp-3806	3261	14	hippocampus	hippocampus	NOUN
fnp-3806	3261	15	and	and	CCONJ
fnp-3806	3261	16	inferior	inferior	ADJ
fnp-3806	3261	17	parietal	parietal	ADJ
fnp-3806	3261	18	lobule	lobule	NOUN
fnp-3806	3261	19	in	in	ADP
fnp-3806	3261	20	subjects	subject	NOUN
fnp-3806	3261	21	with	with	ADP
fnp-3806	3261	22	alzheimer	alzheimer	PROPN
fnp-3806	3261	23	’s	’s	PART
fnp-3806	3261	24	disease	disease	NOUN
fnp-3806	3261	25	and	and	CCONJ
fnp-3806	3261	26	mild	mild	ADJ
fnp-3806	3261	27	cognitive	cognitive	ADJ
fnp-3806	3261	28	impairment	impairment	NOUN
fnp-3806	3261	29	:	:	PUNCT
fnp-3806	3261	30	implications	implication	NOUN
fnp-3806	3261	31	for	for	ADP
fnp-3806	3261	32	progression	progression	NOUN
fnp-3806	3261	33	of	of	ADP
fnp-3806	3261	34	ad	ad	NOUN
fnp-3806	3261	35	.	.	PUNCT
fnp-3806	3262	1	j	j	PROPN
fnp-3806	3262	2	proteome	proteome	PROPN
fnp-3806	3262	3	res	res	PROPN
fnp-3806	3262	4	2009;8	2009;8	NUM
fnp-3806	3262	5	:	:	PUNCT
fnp-3806	3262	6	471	471	NUM
fnp-3806	3262	7	-	-	SYM
fnp-3806	3262	8	482	482	NUM
fnp-3806	3262	9	.	.	PUNCT
fnp-3806	3262	10	https://doi.org/10.1021/pr800667a	https://doi.org/10.1021/pr800667a	PROPN
fnp-3806	3262	11	serrano	serrano	PROPN
fnp-3806	3262	12	-	-	PUNCT
fnp-3806	3262	13	pozo	pozo	PROPN
fnp-3806	3262	14	a	a	PROPN
fnp-3806	3262	15	,	,	PUNCT
fnp-3806	3262	16	gomez	gomez	PROPN
fnp-3806	3262	17	-	-	PUNCT
fnp-3806	3262	18	isla	isla	PROPN
fnp-3806	3262	19	t	t	PROPN
fnp-3806	3262	20	,	,	PUNCT
fnp-3806	3262	21	growdon	growdon	VERB
fnp-3806	3262	22	jh	jh	PROPN
fnp-3806	3262	23	,	,	PUNCT
fnp-3806	3262	24	et	et	PROPN
fnp-3806	3262	25	al	al	PROPN
fnp-3806	3262	26	.	.	PUNCT
fnp-3806	3263	1	a	a	DET
fnp-3806	3263	2	phenotypic	phenotypic	ADJ
fnp-3806	3263	3	change	change	NOUN
fnp-3806	3263	4	but	but	CCONJ
fnp-3806	3263	5	not	not	PART
fnp-3806	3263	6	proliferation	proliferation	NOUN
fnp-3806	3263	7	underlies	underlie	VERB
fnp-3806	3263	8	glial	glial	ADJ
fnp-3806	3263	9	responses	response	NOUN
fnp-3806	3263	10	in	in	ADP
fnp-3806	3263	11	alzheimer	alzheimer	PROPN
fnp-3806	3263	12	disease	disease	PROPN
fnp-3806	3263	13	.	.	PUNCT
fnp-3806	3264	1	am	be	AUX
fnp-3806	3264	2	j	j	PROPN
fnp-3806	3264	3	pathol	pathol	NOUN
fnp-3806	3264	4	2013;182:2332	2013;182:2332	PROPN
fnp-3806	3264	5	-	-	SYM
fnp-3806	3264	6	2344	2344	NUM
fnp-3806	3264	7	.	.	PUNCT
fnp-3806	3265	1	https://doi.org/10.1016/j.ajpath.2013.02.031	https://doi.org/10.1016/j.ajpath.2013.02.031	PROPN
fnp-3806	3265	2	perez	perez	PROPN
fnp-3806	3265	3	-	-	PUNCT
fnp-3806	3265	4	nievas	nievas	PROPN
fnp-3806	3265	5	bg	bg	PROPN
fnp-3806	3265	6	,	,	PUNCT
fnp-3806	3265	7	serrano	serrano	PROPN
fnp-3806	3265	8	-	-	PUNCT
fnp-3806	3265	9	pozo	pozo	PROPN
fnp-3806	3265	10	a.	a.	NOUN
fnp-3806	3265	11	deciphering	decipher	VERB
fnp-3806	3265	12	the	the	DET
fnp-3806	3265	13	astrocyte	astrocyte	NOUN
fnp-3806	3265	14	reaction	reaction	NOUN
fnp-3806	3265	15	in	in	ADP
fnp-3806	3265	16	alzheimer	alzheimer	PROPN
fnp-3806	3265	17	’s	’s	PART
fnp-3806	3265	18	disease	disease	NOUN
fnp-3806	3265	19	.	.	PUNCT
fnp-3806	3266	1	front	front	ADJ
fnp-3806	3266	2	aging	age	VERB
fnp-3806	3266	3	neurosci	neurosci	NOUN
fnp-3806	3266	4	2018;10:114	2018;10:114	NUM
fnp-3806	3266	5	.	.	PUNCT
fnp-3806	3267	1	https://doi.org/10.3389/fnagi.2018.00114	https://doi.org/10.3389/fnagi.2018.00114	PROPN
fnp-3806	3267	2	batiuk	batiuk	VERB
fnp-3806	3267	3	my	my	PRON
fnp-3806	3267	4	,	,	PUNCT
fnp-3806	3267	5	martirosyan	martirosyan	PROPN
fnp-3806	3267	6	a	a	ADV
fnp-3806	3267	7	,	,	PUNCT
fnp-3806	3267	8	wahis	wahis	PROPN
fnp-3806	3267	9	j	j	PROPN
fnp-3806	3267	10	,	,	PUNCT
fnp-3806	3267	11	et	et	PROPN
fnp-3806	3267	12	al	al	PROPN
fnp-3806	3267	13	.	.	PUNCT
fnp-3806	3267	14	identification	identification	NOUN
fnp-3806	3267	15	of	of	ADP
fnp-3806	3267	16	region	region	NOUN
fnp-3806	3267	17	-	-	PUNCT
fnp-3806	3267	18	specific	specific	ADJ
fnp-3806	3267	19	astrocyte	astrocyte	NOUN
fnp-3806	3267	20	subtypes	subtype	NOUN
fnp-3806	3267	21	at	at	ADP
fnp-3806	3267	22	single	single	ADJ
fnp-3806	3267	23	cell	cell	NOUN
fnp-3806	3267	24	resolution	resolution	NOUN
fnp-3806	3267	25	.	.	PUNCT
fnp-3806	3268	1	nat	nat	PROPN
fnp-3806	3268	2	commun	commun	PROPN
fnp-3806	3268	3	2020;11	2020;11	NUM
fnp-3806	3268	4	:	:	PUNCT
fnp-3806	3268	5	1220	1220	NUM
fnp-3806	3268	6	.	.	PUNCT
fnp-3806	3268	7	https://doi.org/10.1038/s41467-019-14198-8	https://doi.org/10.1038/s41467-019-14198-8	NUM
fnp-3806	3268	8	sofroniew	sofroniew	VERB
fnp-3806	3268	9	mv	mv	PROPN
fnp-3806	3268	10	.	.	PROPN
fnp-3806	3268	11	astrocyte	astrocyte	NOUN
fnp-3806	3268	12	reactivity	reactivity	NOUN
fnp-3806	3268	13	:	:	PUNCT
fnp-3806	3268	14	subtypes	subtype	NOUN
fnp-3806	3268	15	,	,	PUNCT
fnp-3806	3268	16	states	state	NOUN
fnp-3806	3268	17	,	,	PUNCT
fnp-3806	3268	18	and	and	CCONJ
fnp-3806	3268	19	functions	function	NOUN
fnp-3806	3268	20	in	in	ADP
fnp-3806	3268	21	cns	cns	NOUN
fnp-3806	3268	22	innate	innate	ADJ
fnp-3806	3268	23	immunity	immunity	NOUN
fnp-3806	3268	24	.	.	PUNCT
fnp-3806	3269	1	trends	trend	NOUN
fnp-3806	3269	2	immunol	immunol	NOUN
fnp-3806	3269	3	2020;41:758	2020;41:758	NOUN
fnp-3806	3269	4	-	-	SYM
fnp-3806	3269	5	770	770	NUM
fnp-3806	3269	6	.	.	PUNCT
fnp-3806	3270	1	https://doi.org/10.1016/j.it.2020.07.004	https://doi.org/10.1016/j.it.2020.07.004	ADJ
fnp-3806	3270	2	zamanian	zamanian	PROPN
fnp-3806	3270	3	jl	jl	PROPN
fnp-3806	3270	4	,	,	PUNCT
fnp-3806	3270	5	xu	xu	PROPN
fnp-3806	3270	6	l	l	PROPN
fnp-3806	3270	7	,	,	PUNCT
fnp-3806	3270	8	foo	foo	PROPN
fnp-3806	3270	9	lc	lc	PROPN
fnp-3806	3270	10	,	,	PUNCT
fnp-3806	3270	11	et	et	PROPN
fnp-3806	3270	12	al	al	PROPN
fnp-3806	3270	13	.	.	PUNCT
fnp-3806	3271	1	genomic	genomic	ADJ
fnp-3806	3271	2	analysis	analysis	NOUN
fnp-3806	3271	3	of	of	ADP
fnp-3806	3271	4	reactive	reactive	ADJ
fnp-3806	3271	5	astrogliosis	astrogliosis	NOUN
fnp-3806	3271	6	.	.	PUNCT
fnp-3806	3272	1	j	j	PROPN
fnp-3806	3272	2	neurosci	neurosci	PROPN
fnp-3806	3272	3	2012;32:6391	2012;32:6391	NUM
fnp-3806	3272	4	-	-	SYM
fnp-3806	3272	5	6410	6410	NUM
fnp-3806	3272	6	.	.	PUNCT
fnp-3806	3273	1	https://doi.org/10.1523/jneurosci.6221-11.2012	https://doi.org/10.1523/jneurosci.6221-11.2012	NOUN
fnp-3806	3273	2	escartin	escartin	X
fnp-3806	3273	3	c	c	NOUN
fnp-3806	3273	4	,	,	PUNCT
fnp-3806	3273	5	galea	galea	NOUN
fnp-3806	3273	6	e	e	NOUN
fnp-3806	3273	7	,	,	PUNCT
fnp-3806	3273	8	lakatos	lakato	VERB
fnp-3806	3273	9	a	a	PRON
fnp-3806	3273	10	,	,	PUNCT
fnp-3806	3273	11	et	et	PROPN
fnp-3806	3273	12	al	al	PROPN
fnp-3806	3273	13	.	.	PROPN
fnp-3806	3273	14	reactive	reactive	ADJ
fnp-3806	3273	15	astrocyte	astrocyte	NOUN
fnp-3806	3273	16	nomenclature	nomenclature	NOUN
fnp-3806	3273	17	,	,	PUNCT
fnp-3806	3273	18	definitions	definition	NOUN
fnp-3806	3273	19	and	and	CCONJ
fnp-3806	3273	20	future	future	ADJ
fnp-3806	3273	21	directions	direction	NOUN
fnp-3806	3273	22	.	.	PUNCT
fnp-3806	3274	1	nat	nat	PROPN
fnp-3806	3274	2	neurosci	neurosci	PROPN
fnp-3806	3274	3	2021;24:312	2021;24:312	VERB
fnp-3806	3274	4	-	-	SYM
fnp-3806	3274	5	325	325	NUM
fnp-3806	3274	6	.	.	PUNCT
fnp-3806	3275	1	https://doi.org/10.1038/s41593-020-00783-4	https://doi.org/10.1038/s41593-020-00783-4	PROPN
fnp-3806	3275	2	haxby	haxby	VERB
fnp-3806	3275	3	jv	jv	PROPN
fnp-3806	3275	4	,	,	PUNCT
fnp-3806	3275	5	grady	grady	PROPN
fnp-3806	3275	6	cl	cl	PROPN
fnp-3806	3275	7	,	,	PUNCT
fnp-3806	3275	8	koss	koss	PROPN
fnp-3806	3275	9	e	e	PROPN
fnp-3806	3275	10	,	,	PUNCT
fnp-3806	3275	11	et	et	PROPN
fnp-3806	3275	12	al	al	PROPN
fnp-3806	3275	13	.	.	PUNCT
fnp-3806	3276	1	longitudinal	longitudinal	ADJ
fnp-3806	3276	2	study	study	NOUN
fnp-3806	3276	3	of	of	ADP
fnp-3806	3276	4	cerebral	cerebral	ADJ
fnp-3806	3276	5	metabolic	metabolic	NOUN
fnp-3806	3276	6	asymmetries	asymmetry	NOUN
fnp-3806	3276	7	and	and	CCONJ
fnp-3806	3276	8	associated	associate	VERB
fnp-3806	3276	9	neuropsychological	neuropsychological	ADJ
fnp-3806	3276	10	patterns	pattern	NOUN
fnp-3806	3276	11	in	in	ADP
fnp-3806	3276	12	early	early	ADJ
fnp-3806	3276	13	dementia	dementia	NOUN
fnp-3806	3276	14	of	of	ADP
fnp-3806	3276	15	the	the	DET
fnp-3806	3276	16	alzheimer	alzheimer	PROPN
fnp-3806	3276	17	type	type	NOUN
fnp-3806	3276	18	.	.	PUNCT
fnp-3806	3277	1	arch	arch	ADJ
fnp-3806	3277	2	neurol	neurol	PROPN
fnp-3806	3277	3	1990;47	1990;47	NUM
fnp-3806	3277	4	:	:	PUNCT
fnp-3806	3277	5	753	753	NUM
fnp-3806	3277	6	-	-	SYM
fnp-3806	3277	7	760	760	NUM
fnp-3806	3277	8	.	.	PUNCT
fnp-3806	3278	1	https://doi.org/10.1001/archneur.1990.00530070043010	https://doi.org/10.1001/archneur.1990.00530070043010	PROPN
fnp-3806	3278	2	small	small	ADJ
fnp-3806	3278	3	gw	gw	PROPN
fnp-3806	3278	4	,	,	PUNCT
fnp-3806	3278	5	ercoli	ercoli	PROPN
fnp-3806	3278	6	lm	lm	PROPN
fnp-3806	3278	7	,	,	PUNCT
fnp-3806	3278	8	silverman	silverman	PROPN
fnp-3806	3278	9	dh	dh	PROPN
fnp-3806	3278	10	,	,	PUNCT
fnp-3806	3278	11	et	et	PROPN
fnp-3806	3278	12	al	al	PROPN
fnp-3806	3278	13	.	.	PROPN
fnp-3806	3278	14	cerebral	cerebral	ADJ
fnp-3806	3278	15	metabolic	metabolic	NOUN
fnp-3806	3278	16	and	and	CCONJ
fnp-3806	3278	17	cognitive	cognitive	ADJ
fnp-3806	3278	18	decline	decline	NOUN
fnp-3806	3278	19	in	in	ADP
fnp-3806	3278	20	persons	person	NOUN
fnp-3806	3278	21	at	at	ADP
fnp-3806	3278	22	genetic	genetic	ADJ
fnp-3806	3278	23	risk	risk	NOUN
fnp-3806	3278	24	for	for	ADP
fnp-3806	3278	25	alzheimer	alzheimer	PROPN
fnp-3806	3278	26	’s	’s	PART
fnp-3806	3278	27	disease	disease	NOUN
fnp-3806	3278	28	.	.	PUNCT
fnp-3806	3279	1	proc	proc	PROPN
fnp-3806	3279	2	natl	natl	PROPN
fnp-3806	3279	3	acad	acad	PROPN
fnp-3806	3279	4	sci	sci	PROPN
fnp-3806	3279	5	usa	usa	PROPN
fnp-3806	3279	6	2000;97:6037	2000;97:6037	PROPN
fnp-3806	3279	7	-	-	SYM
fnp-3806	3279	8	6042	6042	NUM
fnp-3806	3279	9	.	.	PUNCT
fnp-3806	3280	1	https://doi.org/10.1073/pnas.090106797	https://doi.org/10.1073/pnas.090106797	PROPN
fnp-3806	3281	1	de	de	PROPN
fnp-3806	3281	2	leon	leon	PROPN
fnp-3806	3281	3	mj	mj	PROPN
fnp-3806	3281	4	,	,	PUNCT
fnp-3806	3281	5	convit	convit	PROPN
fnp-3806	3281	6	a	a	PRON
fnp-3806	3281	7	,	,	PUNCT
fnp-3806	3281	8	wolf	wolf	PROPN
fnp-3806	3281	9	ot	ot	INTJ
fnp-3806	3281	10	,	,	PUNCT
fnp-3806	3281	11	et	et	PROPN
fnp-3806	3281	12	al	al	PROPN
fnp-3806	3281	13	.	.	PROPN
fnp-3806	3281	14	prediction	prediction	NOUN
fnp-3806	3281	15	of	of	ADP
fnp-3806	3281	16	cognitive	cognitive	ADJ
fnp-3806	3281	17	decline	decline	NOUN
fnp-3806	3281	18	in	in	ADP
fnp-3806	3281	19	normal	normal	ADJ
fnp-3806	3281	20	elderly	elderly	ADJ
fnp-3806	3281	21	subjects	subject	NOUN
fnp-3806	3281	22	with	with	ADP
fnp-3806	3281	23	2-[(18)f]fluoro-2	2-[(18)f]fluoro-2	NUM
fnp-3806	3281	24	-	-	PUNCT
fnp-3806	3281	25	deoxy	deoxy	VERB
fnp-3806	3281	26	-	-	PUNCT
fnp-3806	3281	27	d	d	NOUN
fnp-3806	3281	28	-	-	PUNCT
fnp-3806	3281	29	glucose	glucose	NOUN
fnp-3806	3281	30	/	/	SYM
fnp-3806	3281	31	poitron	poitron	NOUN
fnp-3806	3281	32	-	-	PUNCT
fnp-3806	3281	33	emission	emission	NOUN
fnp-3806	3281	34	tomography	tomography	NOUN
fnp-3806	3281	35	(	(	PUNCT
fnp-3806	3281	36	fdg	fdg	PROPN
fnp-3806	3281	37	/	/	SYM
fnp-3806	3281	38	pet	pet	NOUN
fnp-3806	3281	39	)	)	PUNCT
fnp-3806	3281	40	.	.	PUNCT
fnp-3806	3282	1	proc	proc	PROPN
fnp-3806	3282	2	natl	natl	PROPN
fnp-3806	3282	3	acad	acad	PROPN
fnp-3806	3282	4	sci	sci	PROPN
fnp-3806	3282	5	usa	usa	PROPN
fnp-3806	3282	6	2001;98:10966	2001;98:10966	PROPN
fnp-3806	3282	7	-	-	PROPN
fnp-3806	3282	8	10971	10971	NUM
fnp-3806	3282	9	.	.	PUNCT
fnp-3806	3283	1	https://doi.org/10.1073/pnas.191044198	https://doi.org/10.1073/pnas.191044198	ADJ
fnp-3806	3283	2	mosconi	mosconi	PROPN
fnp-3806	3283	3	l	l	PROPN
fnp-3806	3283	4	,	,	PUNCT
fnp-3806	3283	5	de	de	X
fnp-3806	3283	6	santi	santi	PROPN
fnp-3806	3283	7	s	s	PROPN
fnp-3806	3283	8	,	,	PUNCT
fnp-3806	3283	9	li	li	PROPN
fnp-3806	3283	10	j	j	PROPN
fnp-3806	3283	11	,	,	PUNCT
fnp-3806	3283	12	et	et	PROPN
fnp-3806	3283	13	al	al	PROPN
fnp-3806	3283	14	.	.	PROPN
fnp-3806	3283	15	hippocampal	hippocampal	PROPN
fnp-3806	3283	16	hypometabolism	hypometabolism	NOUN
fnp-3806	3283	17	predicts	predict	VERB
fnp-3806	3283	18	cognitive	cognitive	ADJ
fnp-3806	3283	19	decline	decline	NOUN
fnp-3806	3283	20	from	from	ADP
fnp-3806	3283	21	normal	normal	ADJ
fnp-3806	3283	22	aging	aging	NOUN
fnp-3806	3283	23	.	.	PUNCT
fnp-3806	3284	1	neurobiol	neurobiol	NOUN
fnp-3806	3284	2	aging	age	VERB
fnp-3806	3284	3	2008;29:676	2008;29:676	NOUN
fnp-3806	3284	4	-	-	SYM
fnp-3806	3284	5	692	692	NUM
fnp-3806	3284	6	.	.	PUNCT
fnp-3806	3285	1	https://doi.org/10.1016/j.neurobiolaging.2006.12.008	https://doi.org/10.1016/j.neurobiolaging.2006.12.008	PROPN
fnp-3806	3285	2	van	van	PROPN
fnp-3806	3285	3	hall	hall	PROPN
fnp-3806	3285	4	g	g	PROPN
fnp-3806	3285	5	,	,	PUNCT
fnp-3806	3285	6	stromstad	stromstad	PROPN
fnp-3806	3285	7	m	m	PROPN
fnp-3806	3285	8	,	,	PUNCT
fnp-3806	3285	9	rasmussen	rasmussen	PROPN
fnp-3806	3285	10	p	p	PROPN
fnp-3806	3285	11	,	,	PUNCT
fnp-3806	3285	12	et	et	PROPN
fnp-3806	3285	13	al	al	PROPN
fnp-3806	3285	14	.	.	PUNCT
fnp-3806	3286	1	blood	blood	NOUN
fnp-3806	3286	2	lactate	lactate	PROPN
fnp-3806	3286	3	is	be	AUX
fnp-3806	3286	4	an	an	DET
fnp-3806	3286	5	important	important	ADJ
fnp-3806	3286	6	energy	energy	NOUN
fnp-3806	3286	7	source	source	NOUN
fnp-3806	3286	8	for	for	ADP
fnp-3806	3286	9	the	the	DET
fnp-3806	3286	10	human	human	ADJ
fnp-3806	3286	11	brain	brain	NOUN
fnp-3806	3286	12	.	.	PUNCT
fnp-3806	3287	1	j	j	PROPN
fnp-3806	3287	2	cereb	cereb	PROPN
fnp-3806	3287	3	blood	blood	NOUN
fnp-3806	3287	4	flow	flow	NOUN
fnp-3806	3287	5	metab	metab	NOUN
fnp-3806	3287	6	2009;29:1121	2009;29:1121	PROPN
fnp-3806	3287	7	-	-	SYM
fnp-3806	3287	8	1129	1129	NUM
fnp-3806	3287	9	.	.	PUNCT
fnp-3806	3288	1	https://doi.org/10.1038/jcbfm.2009.35	https://doi.org/10.1038/jcbfm.2009.35	PROPN
fnp-3806	3288	2	wyss	wyss	PROPN
fnp-3806	3288	3	mt	mt	PROPN
fnp-3806	3288	4	,	,	PUNCT
fnp-3806	3288	5	jolivet	jolivet	NOUN
fnp-3806	3288	6	r	r	NOUN
fnp-3806	3288	7	,	,	PUNCT
fnp-3806	3288	8	buck	buck	NOUN
fnp-3806	3288	9	a	a	X
fnp-3806	3288	10	,	,	PUNCT
fnp-3806	3288	11	et	et	PROPN
fnp-3806	3288	12	al	al	PROPN
fnp-3806	3288	13	.	.	PROPN
fnp-3806	3289	1	in	in	ADP
fnp-3806	3289	2	vivo	vivo	ADJ
fnp-3806	3289	3	evidence	evidence	NOUN
fnp-3806	3289	4	for	for	ADP
fnp-3806	3289	5	lactate	lactate	NOUN
fnp-3806	3289	6	as	as	ADP
fnp-3806	3289	7	a	a	DET
fnp-3806	3289	8	neuronal	neuronal	ADJ
fnp-3806	3289	9	energy	energy	NOUN
fnp-3806	3289	10	source	source	NOUN
fnp-3806	3289	11	.	.	PUNCT
fnp-3806	3290	1	j	j	PROPN
fnp-3806	3290	2	neurosci	neurosci	PROPN
fnp-3806	3290	3	2011;31:7477	2011;31:7477	PROPN
fnp-3806	3290	4	-	-	PUNCT
fnp-3806	3290	5	7485	7485	NUM
fnp-3806	3290	6	.	.	PUNCT
fnp-3806	3291	1	https://doi.org/10.1523/jneurosci.0415-11.2011	https://doi.org/10.1523/jneurosci.0415-11.2011	NOUN
fnp-3806	3291	2	proia	proia	NOUN
fnp-3806	3291	3	p	p	NOUN
fnp-3806	3291	4	,	,	PUNCT
fnp-3806	3291	5	di	di	NOUN
fnp-3806	3291	6	liegro	liegro	PROPN
fnp-3806	3291	7	cm	cm	PROPN
fnp-3806	3291	8	,	,	PUNCT
fnp-3806	3291	9	schiera	schiera	NOUN
fnp-3806	3291	10	g	g	NOUN
fnp-3806	3291	11	,	,	PUNCT
fnp-3806	3291	12	et	et	PROPN
fnp-3806	3291	13	al	al	PROPN
fnp-3806	3291	14	.	.	PUNCT
fnp-3806	3291	15	lactate	lactate	PROPN
fnp-3806	3291	16	as	as	ADP
fnp-3806	3291	17	a	a	DET
fnp-3806	3291	18	metabolite	metabolite	NOUN
fnp-3806	3291	19	and	and	CCONJ
fnp-3806	3291	20	a	a	DET
fnp-3806	3291	21	regulator	regulator	NOUN
fnp-3806	3291	22	in	in	ADP
fnp-3806	3291	23	the	the	DET
fnp-3806	3291	24	central	central	ADJ
fnp-3806	3291	25	nervous	nervous	ADJ
fnp-3806	3291	26	system	system	NOUN
fnp-3806	3291	27	.	.	PUNCT
fnp-3806	3292	1	int	int	PROPN
fnp-3806	3292	2	j	j	PROPN
fnp-3806	3292	3	mol	mol	ADP
fnp-3806	3292	4	sci	sci	PROPN
fnp-3806	3292	5	2016;17:1450	2016;17:1450	PROPN
fnp-3806	3292	6	.	.	PUNCT
fnp-3806	3293	1	https://doi.org/10.3390/ijms17091450	https://doi.org/10.3390/ijms17091450	NOUN
fnp-3806	3293	2	alberini	alberini	PROPN
fnp-3806	3293	3	cm	cm	PROPN
fnp-3806	3293	4	,	,	PUNCT
fnp-3806	3293	5	cruz	cruz	PROPN
fnp-3806	3293	6	e	e	PROPN
fnp-3806	3293	7	,	,	PUNCT
fnp-3806	3293	8	descalzi	descalzi	PROPN
fnp-3806	3293	9	g	g	PROPN
fnp-3806	3293	10	,	,	PUNCT
fnp-3806	3293	11	et	et	PROPN
fnp-3806	3293	12	al	al	PROPN
fnp-3806	3293	13	.	.	PROPN
fnp-3806	3293	14	astrocyte	astrocyte	PROPN
fnp-3806	3293	15	glycogen	glycogen	PROPN
fnp-3806	3293	16	and	and	CCONJ
fnp-3806	3293	17	lactate	lactate	PROPN
fnp-3806	3293	18	:	:	PUNCT
fnp-3806	3293	19	new	new	ADJ
fnp-3806	3293	20	insights	insight	NOUN
fnp-3806	3293	21	into	into	ADP
fnp-3806	3293	22	learning	learning	NOUN
fnp-3806	3293	23	and	and	CCONJ
fnp-3806	3293	24	memory	memory	NOUN
fnp-3806	3293	25	mechanisms	mechanism	NOUN
fnp-3806	3293	26	.	.	PUNCT
fnp-3806	3294	1	glia	glia	NOUN
fnp-3806	3294	2	2018;66:1244	2018;66:1244	NUM
fnp-3806	3294	3	-	-	SYM
fnp-3806	3294	4	1262	1262	NUM
fnp-3806	3294	5	.	.	PUNCT
fnp-3806	3295	1	https://doi.org/10.1002/glia.23250	https://doi.org/10.1002/glia.23250	NOUN
fnp-3806	3295	2	zhang	zhang	PROPN
fnp-3806	3295	3	m	m	PROPN
fnp-3806	3295	4	,	,	PUNCT
fnp-3806	3295	5	cheng	cheng	PROPN
fnp-3806	3295	6	x	x	PROPN
fnp-3806	3295	7	,	,	PUNCT
fnp-3806	3295	8	dang	dang	INTJ
fnp-3806	3295	9	r	r	NOUN
fnp-3806	3295	10	,	,	PUNCT
fnp-3806	3295	11	et	et	PROPN
fnp-3806	3295	12	al	al	PROPN
fnp-3806	3295	13	.	.	PUNCT
fnp-3806	3295	14	lactate	lactate	PROPN
fnp-3806	3295	15	deficit	deficit	NOUN
fnp-3806	3295	16	in	in	ADP
fnp-3806	3295	17	an	an	DET
fnp-3806	3295	18	alzheimer	alzheimer	NOUN
fnp-3806	3295	19	disease	disease	NOUN
fnp-3806	3295	20	mouse	mouse	NOUN
fnp-3806	3295	21	model	model	NOUN
fnp-3806	3295	22	:	:	PUNCT
fnp-3806	3295	23	the	the	DET
fnp-3806	3295	24	relationship	relationship	NOUN
fnp-3806	3295	25	with	with	ADP
fnp-3806	3295	26	neuronal	neuronal	ADJ
fnp-3806	3295	27	damage	damage	NOUN
fnp-3806	3295	28	.	.	PUNCT
fnp-3806	3296	1	j	j	PROPN
fnp-3806	3296	2	neuropathol	neuropathol	PROPN
fnp-3806	3296	3	exp	exp	PROPN
fnp-3806	3296	4	neurol	neurol	PROPN
fnp-3806	3296	5	2018;77:1163	2018;77:1163	NUM
fnp-3806	3296	6	-	-	SYM
fnp-3806	3296	7	1167	1167	NUM
fnp-3806	3296	8	.	.	PUNCT
fnp-3806	3297	1	https://doi.org/10.1093/jnen/nly102	https://doi.org/10.1093/jnen/nly102	PROPN
fnp-3806	3297	2	le	le	X
fnp-3806	3297	3	foll	foll	PROPN
fnp-3806	3297	4	c	c	PROPN
fnp-3806	3297	5	,	,	PUNCT
fnp-3806	3297	6	levin	levin	PROPN
fnp-3806	3297	7	be	be	PROPN
fnp-3806	3297	8	.	.	PUNCT
fnp-3806	3298	1	fatty	fatty	VERB
fnp-3806	3298	2	acid	acid	NOUN
fnp-3806	3298	3	-	-	PUNCT
fnp-3806	3298	4	induced	induce	VERB
fnp-3806	3298	5	astrocyte	astrocyte	NOUN
fnp-3806	3298	6	ketone	ketone	NOUN
fnp-3806	3298	7	production	production	NOUN
fnp-3806	3298	8	and	and	CCONJ
fnp-3806	3298	9	the	the	DET
fnp-3806	3298	10	control	control	NOUN
fnp-3806	3298	11	of	of	ADP
fnp-3806	3298	12	food	food	NOUN
fnp-3806	3298	13	intake	intake	NOUN
fnp-3806	3298	14	.	.	PUNCT
fnp-3806	3299	1	am	be	AUX
fnp-3806	3299	2	j	j	PROPN
fnp-3806	3299	3	physiol	physiol	PROPN
fnp-3806	3299	4	regul	regul	PROPN
fnp-3806	3299	5	integr	integr	PROPN
fnp-3806	3299	6	comp	comp	PROPN
fnp-3806	3299	7	physiol	physiol	PROPN
fnp-3806	3299	8	2016;310	2016;310	NUM
fnp-3806	3299	9	:	:	PUNCT
fnp-3806	3299	10	r1186	r1186	NOUN
fnp-3806	3299	11	-	-	PUNCT
fnp-3806	3299	12	1192	1192	NUM
fnp-3806	3299	13	.	.	PUNCT
fnp-3806	3300	1	https://doi.org/10.1152/ajpregu.00113.201	https://doi.org/10.1152/ajpregu.00113.201	NOUN
fnp-3806	3300	2	.	.	PUNCT
fnp-3806	3301	1	guzman	guzman	PROPN
fnp-3806	3301	2	m	m	PROPN
fnp-3806	3301	3	,	,	PUNCT
fnp-3806	3301	4	blazquez	blazquez	NOUN
fnp-3806	3301	5	c.	c.	NOUN
fnp-3806	3301	6	is	be	AUX
fnp-3806	3301	7	there	there	PRON
fnp-3806	3301	8	an	an	DET
fnp-3806	3301	9	astrocyte	astrocyte	NOUN
fnp-3806	3301	10	-	-	PUNCT
fnp-3806	3301	11	neuron	neuron	NOUN
fnp-3806	3301	12	ketone	ketone	NOUN
fnp-3806	3301	13	body	body	NOUN
fnp-3806	3301	14	shuttle	shuttle	NOUN
fnp-3806	3301	15	?	?	PUNCT
fnp-3806	3302	1	trends	trend	NOUN
fnp-3806	3302	2	endocrinol	endocrinol	VERB
fnp-3806	3302	3	metab	metab	ADJ
fnp-3806	3302	4	2001;12:169	2001;12:169	PROPN
fnp-3806	3302	5	-	-	SYM
fnp-3806	3302	6	173	173	NUM
fnp-3806	3302	7	.	.	PUNCT
fnp-3806	3303	1	https://doi.org/10.1016/s1043-2760(00)00370-2	https://doi.org/10.1016/s1043-2760(00)00370-2	PROPN
fnp-3806	3303	2	panov	panov	PROPN
fnp-3806	3303	3	a	a	PROPN
fnp-3806	3303	4	,	,	PUNCT
fnp-3806	3303	5	orynbayeva	orynbayeva	PROPN
fnp-3806	3304	1	z	z	PROPN
fnp-3806	3304	2	,	,	PUNCT
fnp-3806	3304	3	vavilin	vavilin	PROPN
fnp-3806	3304	4	v	v	PROPN
fnp-3806	3304	5	,	,	PUNCT
fnp-3806	3304	6	et	et	PROPN
fnp-3806	3304	7	al	al	PROPN
fnp-3806	3304	8	.	.	PUNCT
fnp-3806	3305	1	fatty	fatty	PROPN
fnp-3806	3305	2	acids	acid	NOUN
fnp-3806	3305	3	in	in	ADP
fnp-3806	3305	4	energy	energy	NOUN
fnp-3806	3305	5	metabolism	metabolism	NOUN
fnp-3806	3305	6	of	of	ADP
fnp-3806	3305	7	the	the	DET
fnp-3806	3305	8	central	central	ADJ
fnp-3806	3305	9	nervous	nervous	ADJ
fnp-3806	3305	10	system	system	NOUN
fnp-3806	3305	11	.	.	PUNCT
fnp-3806	3306	1	biomed	biome	VERB
fnp-3806	3306	2	res	re	NOUN
fnp-3806	3306	3	int	int	PROPN
fnp-3806	3306	4	2014;2014:472459	2014;2014:472459	NUM
fnp-3806	3306	5	.	.	PUNCT
fnp-3806	3307	1	https://doi.org/10.1155/2014/472459	https://doi.org/10.1155/2014/472459	NOUN
fnp-3806	3307	2	bélanger	bélanger	PROPN
fnp-3806	3307	3	m	m	PROPN
fnp-3806	3307	4	,	,	PUNCT
fnp-3806	3307	5	allaman	allaman	NOUN
fnp-3806	3307	6	i	i	PROPN
fnp-3806	3307	7	,	,	PUNCT
fnp-3806	3307	8	magistretti	magistretti	PROPN
fnp-3806	3307	9	pj	pj	PROPN
fnp-3806	3307	10	.	.	PROPN
fnp-3806	3308	1	brain	brain	PROPN
fnp-3806	3308	2	energy	energy	NOUN
fnp-3806	3308	3	metabolism	metabolism	NOUN
fnp-3806	3308	4	:	:	PUNCT
fnp-3806	3308	5	focus	focus	VERB
fnp-3806	3308	6	on	on	ADP
fnp-3806	3308	7	astrocyte	astrocyte	NOUN
fnp-3806	3308	8	-	-	PUNCT
fnp-3806	3308	9	neuron	neuron	NOUN
fnp-3806	3308	10	metabolic	metabolic	NOUN
fnp-3806	3308	11	cooperation	cooperation	NOUN
fnp-3806	3308	12	.	.	PUNCT
fnp-3806	3309	1	cell	cell	NOUN
fnp-3806	3309	2	metab	metab	NOUN
fnp-3806	3309	3	2011;14:724	2011;14:724	NUM
fnp-3806	3309	4	-	-	SYM
fnp-3806	3309	5	38	38	NUM
fnp-3806	3309	6	.	.	PUNCT
fnp-3806	3310	1	https://doi.org/10.1016/j.cmet.2011.08.016	https://doi.org/10.1016/j.cmet.2011.08.016	PROPN
fnp-3806	3310	2	steele	steele	PROPN
fnp-3806	3310	3	ml	ml	PROPN
fnp-3806	3310	4	,	,	PUNCT
fnp-3806	3310	5	robinson	robinson	PROPN
fnp-3806	3310	6	sr	sr	PROPN
fnp-3806	3310	7	.	.	PUNCT
fnp-3806	3311	1	reactive	reactive	ADJ
fnp-3806	3311	2	astrocytes	astrocyte	NOUN
fnp-3806	3311	3	give	give	VERB
fnp-3806	3311	4	neurons	neuron	NOUN
fnp-3806	3311	5	less	less	ADJ
fnp-3806	3311	6	support	support	NOUN
fnp-3806	3311	7	:	:	PUNCT
fnp-3806	3311	8	implications	implication	NOUN
fnp-3806	3311	9	for	for	ADP
fnp-3806	3311	10	alzheimer	alzheimer	PROPN
fnp-3806	3311	11	's	's	PART
fnp-3806	3311	12	disease	disease	NOUN
fnp-3806	3311	13	.	.	PUNCT
fnp-3806	3312	1	neurobiol	neurobiol	ADJ
fnp-3806	3312	2	aging	age	VERB
fnp-3806	3312	3	2012;33:423.e1	2012;33:423.e1	NOUN
fnp-3806	3312	4	-	-	SYM
fnp-3806	3312	5	13	13	NUM
fnp-3806	3312	6	.	.	PUNCT
fnp-3806	3313	1	https://doi.org/10.1016/j.neurobiolaging.2010.09.018	https://doi.org/10.1016/j.neurobiolaging.2010.09.018	PROPN
fnp-3806	3313	2	zulfiqar	zulfiqar	NUM
fnp-3806	3313	3	s	s	PROPN
fnp-3806	3313	4	,	,	PUNCT
fnp-3806	3313	5	garg	garg	NOUN
fnp-3806	3313	6	p	p	PROPN
fnp-3806	3313	7	,	,	PUNCT
fnp-3806	3313	8	nieweg	nieweg	PROPN
fnp-3806	3313	9	k.	k.	PROPN
fnp-3806	3313	10	contribution	contribution	PROPN
fnp-3806	3313	11	of	of	ADP
fnp-3806	3313	12	astrocytes	astrocyte	NOUN
fnp-3806	3313	13	to	to	ADP
fnp-3806	3313	14	metabolic	metabolic	ADJ
fnp-3806	3313	15	dysfunction	dysfunction	NOUN
fnp-3806	3313	16	in	in	ADP
fnp-3806	3313	17	the	the	DET
fnp-3806	3313	18	alzheimer	alzheimer	NOUN
fnp-3806	3313	19	's	's	PART
fnp-3806	3313	20	disease	disease	NOUN
fnp-3806	3313	21	brain	brain	NOUN
fnp-3806	3313	22	.	.	PUNCT
fnp-3806	3314	1	biol	biol	PROPN
fnp-3806	3314	2	chem	chem	NOUN
fnp-3806	3314	3	2019;400:1113	2019;400:1113	NUM
fnp-3806	3314	4	-	-	SYM
fnp-3806	3314	5	1127	1127	NUM
fnp-3806	3314	6	.	.	PUNCT
fnp-3806	3315	1	https://doi.org/10.1515/hsz-2019-0140	https://doi.org/10.1515/hsz-2019-0140	PROPN
fnp-3806	3315	2	orihuela	orihuela	PROPN
fnp-3806	3315	3	r	r	PROPN
fnp-3806	3315	4	,	,	PUNCT
fnp-3806	3315	5	mcpherson	mcpherson	PROPN
fnp-3806	3315	6	ca	ca	PROPN
fnp-3806	3315	7	,	,	PUNCT
fnp-3806	3315	8	harry	harry	PROPN
fnp-3806	3315	9	gj	gj	PROPN
fnp-3806	3315	10	.	.	PUNCT
fnp-3806	3315	11	microglial	microglial	PROPN
fnp-3806	3315	12	m1	m1	PROPN
fnp-3806	3315	13	/	/	SYM
fnp-3806	3315	14	m2	m2	PROPN
fnp-3806	3315	15	polarization	polarization	NOUN
fnp-3806	3315	16	and	and	CCONJ
fnp-3806	3315	17	metabolic	metabolic	NOUN
fnp-3806	3315	18	states	state	NOUN
fnp-3806	3315	19	.	.	PUNCT
fnp-3806	3316	1	br	br	PROPN
fnp-3806	3317	1	j	j	PROPN
fnp-3806	3317	2	pharmacol	pharmacol	PROPN
fnp-3806	3317	3	2016;173:649	2016;173:649	NUM
fnp-3806	3317	4	-	-	SYM
fnp-3806	3317	5	665	665	NUM
fnp-3806	3317	6	.	.	PUNCT
fnp-3806	3318	1	https://doi.org/10.1111/bph.13139	https://doi.org/10.1111/bph.13139	PROPN
fnp-3806	3318	2	tang	tang	PROPN
fnp-3806	3318	3	y	y	PROPN
fnp-3806	3318	4	,	,	PUNCT
fnp-3806	3318	5	le	le	PROPN
fnp-3806	3318	6	w.	w.	PROPN
fnp-3806	3318	7	differential	differential	PROPN
fnp-3806	3318	8	roles	role	NOUN
fnp-3806	3318	9	of	of	ADP
fnp-3806	3318	10	m1	m1	PROPN
fnp-3806	3318	11	and	and	CCONJ
fnp-3806	3318	12	m2	m2	PROPN
fnp-3806	3318	13	microglia	microglia	PROPN
fnp-3806	3318	14	in	in	ADP
fnp-3806	3318	15	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3318	16	diseases	disease	NOUN
fnp-3806	3318	17	.	.	PUNCT
fnp-3806	3319	1	mol	mol	ADP
fnp-3806	3319	2	neurobiol	neurobiol	PROPN
fnp-3806	3319	3	2016;53:1181	2016;53:1181	PROPN
fnp-3806	3319	4	-	-	SYM
fnp-3806	3319	5	1194	1194	NUM
fnp-3806	3319	6	.	.	PUNCT
fnp-3806	3320	1	https://doi.org/10.1007/s12035-014-9070-5	https://doi.org/10.1007/s12035-014-9070-5	NUM
fnp-3806	3320	2	ransohoff	ransohoff	PROPN
fnp-3806	3320	3	rm	rm	PROPN
fnp-3806	3320	4	.	.	PUNCT
fnp-3806	3321	1	a	a	DET
fnp-3806	3321	2	polarizing	polarizing	NOUN
fnp-3806	3321	3	question	question	NOUN
fnp-3806	3321	4	:	:	PUNCT
fnp-3806	3321	5	do	do	AUX
fnp-3806	3321	6	m1	m1	PROPN
fnp-3806	3321	7	and	and	CCONJ
fnp-3806	3321	8	m2	m2	PROPN
fnp-3806	3322	1	microglia	microglia	NOUN
fnp-3806	3322	2	exist	exist	VERB
fnp-3806	3322	3	?	?	PUNCT
fnp-3806	3323	1	nat	nat	PROPN
fnp-3806	3323	2	neurosci	neurosci	PROPN
fnp-3806	3323	3	2016;19:987	2016;19:987	NUM
fnp-3806	3323	4	-	-	SYM
fnp-3806	3323	5	991	991	NUM
fnp-3806	3323	6	.	.	PUNCT
fnp-3806	3324	1	https://doi.org/10.1038/nn.4338	https://doi.org/10.1038/nn.4338	PROPN
fnp-3806	3324	2	graeber	graeber	PROPN
fnp-3806	3324	3	mb	mb	PROPN
fnp-3806	3324	4	,	,	PUNCT
fnp-3806	3324	5	streit	streit	PROPN
fnp-3806	3324	6	wj	wj	PROPN
fnp-3806	3324	7	.	.	PUNCT
fnp-3806	3325	1	microglia	microglia	ADJ
fnp-3806	3325	2	:	:	PUNCT
fnp-3806	3325	3	biology	biology	NOUN
fnp-3806	3325	4	and	and	CCONJ
fnp-3806	3325	5	pathology	pathology	NOUN
fnp-3806	3325	6	.	.	PUNCT
fnp-3806	3326	1	acta	acta	PROPN
fnp-3806	3326	2	neuropathol	neuropathol	PROPN
fnp-3806	3326	3	2010	2010	NUM
fnp-3806	3326	4	;	;	PUNCT
fnp-3806	3326	5	119:89	119:89	PROPN
fnp-3806	3326	6	-	-	SYM
fnp-3806	3326	7	105	105	NUM
fnp-3806	3326	8	.	.	PUNCT
fnp-3806	3326	9	https://doi.org/10.1007/s00401-009-0622-0	https://doi.org/10.1007/s00401-009-0622-0	NUM
fnp-3806	3326	10	svahn	svahn	PROPN
fnp-3806	3326	11	aj	aj	PROPN
fnp-3806	3326	12	,	,	PUNCT
fnp-3806	3326	13	becker	becker	PROPN
fnp-3806	3326	14	ts	ts	PROPN
fnp-3806	3326	15	,	,	PUNCT
fnp-3806	3326	16	graeber	graeber	PROPN
fnp-3806	3326	17	mb	mb	PROPN
fnp-3806	3326	18	.	.	PROPN
fnp-3806	3326	19	emergent	emergent	ADJ
fnp-3806	3326	20	properties	property	NOUN
fnp-3806	3326	21	of	of	ADP
fnp-3806	3326	22	microglia	microglia	ADJ
fnp-3806	3326	23	.	.	PUNCT
fnp-3806	3327	1	brain	brain	NOUN
fnp-3806	3327	2	pathol	pathol	NOUN
fnp-3806	3327	3	2014;24:665	2014;24:665	NUM
fnp-3806	3327	4	-	-	SYM
fnp-3806	3327	5	670	670	NUM
fnp-3806	3327	6	.	.	PUNCT
fnp-3806	3328	1	https://doi.org/10.1111/bpa.12195	https://doi.org/10.1111/bpa.12195	PROPN
fnp-3806	3328	2	hashemiaghdam	hashemiaghdam	PROPN
fnp-3806	3328	3	a	a	DET
fnp-3806	3328	4	,	,	PUNCT
fnp-3806	3328	5	mroczek	mroczek	NOUN
fnp-3806	3328	6	m.	m.	NOUN
fnp-3806	3328	7	microglia	microglia	ADJ
fnp-3806	3328	8	heterogeneity	heterogeneity	NOUN
fnp-3806	3328	9	and	and	CCONJ
fnp-3806	3328	10	neurodegeneration	neurodegeneration	NOUN
fnp-3806	3328	11	:	:	PUNCT
fnp-3806	3328	12	the	the	DET
fnp-3806	3328	13	emerging	emerge	VERB
fnp-3806	3328	14	paradigm	paradigm	NOUN
fnp-3806	3328	15	of	of	ADP
fnp-3806	3328	16	the	the	DET
fnp-3806	3328	17	role	role	NOUN
fnp-3806	3328	18	of	of	ADP
fnp-3806	3328	19	immunity	immunity	NOUN
fnp-3806	3328	20	in	in	ADP
fnp-3806	3328	21	alzheimer	alzheimer	PROPN
fnp-3806	3328	22	's	's	PART
fnp-3806	3328	23	disease	disease	NOUN
fnp-3806	3328	24	.	.	PUNCT
fnp-3806	3329	1	j	j	PROPN
fnp-3806	3329	2	neuroimmunol	neuroimmunol	PROPN
fnp-3806	3329	3	2020;341:577185	2020;341:577185	X
fnp-3806	3329	4	.	.	PUNCT
fnp-3806	3330	1	https://doi.org/10.1016/j.jneuroim.2020.577185	https://doi.org/10.1016/j.jneuroim.2020.577185	ADJ
fnp-3806	3330	2	streit	streit	PROPN
fnp-3806	3330	3	wj	wj	PROPN
fnp-3806	3330	4	,	,	PUNCT
fnp-3806	3330	5	samkons	samkon	NOUN
fnp-3806	3330	6	nw	nw	PROPN
fnp-3806	3330	7	,	,	PUNCT
fnp-3806	3330	8	kuhns	kuhns	PROPN
fnp-3806	3330	9	aj	aj	PROPN
fnp-3806	3330	10	,	,	PUNCT
fnp-3806	3330	11	et	et	PROPN
fnp-3806	3330	12	al	al	PROPN
fnp-3806	3330	13	.	.	PROPN
fnp-3806	3330	14	dystrophic	dystrophic	ADJ
fnp-3806	3330	15	microglia	microglia	NOUN
fnp-3806	3330	16	in	in	ADP
fnp-3806	3330	17	the	the	DET
fnp-3806	3330	18	aging	age	VERB
fnp-3806	3330	19	human	human	ADJ
fnp-3806	3330	20	brain	brain	NOUN
fnp-3806	3330	21	.	.	PUNCT
fnp-3806	3331	1	glia	glia	PROPN
fnp-3806	3331	2	2004;45:208	2004;45:208	NOUN
fnp-3806	3331	3	-	-	PUNCT
fnp-3806	3331	4	212	212	NUM
fnp-3806	3331	5	.	.	PUNCT
fnp-3806	3332	1	https://doi.org/10.1002/glia.10319	https://doi.org/10.1002/glia.10319	PROPN
fnp-3806	3332	2	yuan	yuan	PROPN
fnp-3806	3332	3	c	c	X
fnp-3806	3332	4	,	,	PUNCT
fnp-3806	3332	5	aierken	aierken	PROPN
fnp-3806	3332	6	a	a	PRON
fnp-3806	3332	7	,	,	PUNCT
fnp-3806	3333	1	xie	xie	PROPN
fnp-3806	3333	2	z	z	PROPN
fnp-3806	3333	3	,	,	PUNCT
fnp-3806	3333	4	et	et	PROPN
fnp-3806	3333	5	al	al	PROPN
fnp-3806	3333	6	.	.	PUNCT
fnp-3806	3334	1	the	the	DET
fnp-3806	3334	2	age	age	NOUN
fnp-3806	3334	3	-	-	PUNCT
fnp-3806	3334	4	related	relate	VERB
fnp-3806	3334	5	microglial	microglial	ADJ
fnp-3806	3334	6	transformation	transformation	NOUN
fnp-3806	3334	7	in	in	ADP
fnp-3806	3334	8	alzheimer	alzheimer	PROPN
fnp-3806	3334	9	's	's	PART
fnp-3806	3334	10	disease	disease	NOUN
fnp-3806	3334	11	pathogenesis	pathogenesis	NOUN
fnp-3806	3334	12	.	.	PUNCT
fnp-3806	3335	1	neurobiol	neurobiol	PROPN
fnp-3806	3335	2	aging	age	VERB
fnp-3806	3335	3	2020;92:82	2020;92:82	NUM
fnp-3806	3335	4	-	-	SYM
fnp-3806	3335	5	91	91	NUM
fnp-3806	3335	6	.	.	PUNCT
fnp-3806	3336	1	https://doi.org/10.1016/j.neurobiolaging.2020.03.024	https://doi.org/10.1016/j.neurobiolaging.2020.03.024	PROPN
fnp-3806	3336	2	saez	saez	PROPN
fnp-3806	3336	3	-	-	PUNCT
fnp-3806	3336	4	atienzar	atienzar	PROPN
fnp-3806	3336	5	s	s	PART
fnp-3806	3336	6	,	,	PUNCT
fnp-3806	3336	7	masliah	masliah	PROPN
fnp-3806	3336	8	e.	e.	PROPN
fnp-3806	3336	9	cellular	cellular	PROPN
fnp-3806	3336	10	senescence	senescence	NOUN
fnp-3806	3336	11	and	and	CCONJ
fnp-3806	3336	12	alzheimer	alzheimer	PROPN
fnp-3806	3336	13	disease	disease	PROPN
fnp-3806	3336	14	:	:	PUNCT
fnp-3806	3336	15	the	the	DET
fnp-3806	3336	16	egg	egg	NOUN
fnp-3806	3336	17	and	and	CCONJ
fnp-3806	3336	18	the	the	DET
fnp-3806	3336	19	chicken	chicken	NOUN
fnp-3806	3336	20	scenario	scenario	NOUN
fnp-3806	3336	21	.	.	PUNCT
fnp-3806	3337	1	nat	nat	PROPN
fnp-3806	3337	2	rev	rev	VERB
fnp-3806	3337	3	neurosci	neurosci	PROPN
fnp-3806	3337	4	2020;21:433	2020;21:433	NOUN
fnp-3806	3337	5	-	-	PUNCT
fnp-3806	3337	6	444	444	NUM
fnp-3806	3337	7	.	.	PUNCT
fnp-3806	3338	1	https://doi.org/10.1038/s41583-020-0325-z	https://doi.org/10.1038/s41583-020-0325-z	ADJ
fnp-3806	3338	2	albrecht	albrecht	PROPN
fnp-3806	3338	3	ds	ds	PROPN
fnp-3806	3338	4	,	,	PUNCT
fnp-3806	3338	5	sagare	sagare	VERB
fnp-3806	3338	6	a	a	PRON
fnp-3806	3338	7	,	,	PUNCT
fnp-3806	3338	8	pachicano	pachicano	PROPN
fnp-3806	3338	9	m	m	PROPN
fnp-3806	3338	10	,	,	PUNCT
fnp-3806	3338	11	et	et	PROPN
fnp-3806	3338	12	al	al	PROPN
fnp-3806	3338	13	.	.	PUNCT
fnp-3806	3339	1	early	early	ADJ
fnp-3806	3339	2	neuroinflammation	neuroinflammation	NOUN
fnp-3806	3339	3	is	be	AUX
fnp-3806	3339	4	associated	associate	VERB
fnp-3806	3339	5	with	with	ADP
fnp-3806	3339	6	lower	low	ADJ
fnp-3806	3339	7	amyloid	amyloid	NOUN
fnp-3806	3339	8	and	and	CCONJ
fnp-3806	3339	9	tau	tau	PROPN
fnp-3806	3339	10	levels	level	NOUN
fnp-3806	3339	11	in	in	ADP
fnp-3806	3339	12	cognitively	cognitively	ADV
fnp-3806	3339	13	normal	normal	ADJ
fnp-3806	3339	14	older	old	ADJ
fnp-3806	3339	15	adults	adult	NOUN
fnp-3806	3339	16	.	.	PUNCT
fnp-3806	3340	1	brain	brain	NOUN
fnp-3806	3340	2	behav	behav	PROPN
fnp-3806	3340	3	immun	immun	PROPN
fnp-3806	3340	4	2021;94:299	2021;94:299	PROPN
fnp-3806	3340	5	-	-	PROPN
fnp-3806	3340	6	307	307	NUM
fnp-3806	3340	7	.	.	PUNCT
fnp-3806	3341	1	https://doi.org/10.1016/j.bbi.2021.01.010	https://doi.org/10.1016/j.bbi.2021.01.010	PROPN
fnp-3806	3341	2	dani	dani	PROPN
fnp-3806	3341	3	m	m	PROPN
fnp-3806	3341	4	,	,	PUNCT
fnp-3806	3341	5	wood	wood	NOUN
fnp-3806	3341	6	m	m	PROPN
fnp-3806	3341	7	,	,	PUNCT
fnp-3806	3341	8	mizoguchi	mizoguchi	PROPN
fnp-3806	3341	9	r	r	PROPN
fnp-3806	3341	10	,	,	PUNCT
fnp-3806	3341	11	et	et	PROPN
fnp-3806	3341	12	al	al	PROPN
fnp-3806	3341	13	.	.	PROPN
fnp-3806	3341	14	microglial	microglial	ADJ
fnp-3806	3341	15	activation	activation	NOUN
fnp-3806	3341	16	correlates	correlate	VERB
fnp-3806	3341	17	in	in	ADP
fnp-3806	3341	18	vivo	vivo	NOUN
fnp-3806	3341	19	with	with	ADP
fnp-3806	3341	20	both	both	CCONJ
fnp-3806	3341	21	tau	tau	PROPN
fnp-3806	3341	22	and	and	CCONJ
fnp-3806	3341	23	amyloid	amyloid	NOUN
fnp-3806	3341	24	in	in	ADP
fnp-3806	3341	25	alzheimer	alzheimer	PROPN
fnp-3806	3341	26	's	's	PART
fnp-3806	3341	27	disease	disease	NOUN
fnp-3806	3341	28	.	.	PUNCT
fnp-3806	3342	1	brain	brain	NOUN
fnp-3806	3342	2	2018;141:2740	2018;141:2740	NUM
fnp-3806	3342	3	-	-	SYM
fnp-3806	3342	4	2754	2754	NUM
fnp-3806	3342	5	.	.	PUNCT
fnp-3806	3343	1	https://doi.org/10.1093/brain/awy188	https://doi.org/10.1093/brain/awy188	PROPN
fnp-3806	3343	2	akiyama	akiyama	PROPN
fnp-3806	3343	3	h	h	PROPN
fnp-3806	3343	4	,	,	PUNCT
fnp-3806	3343	5	barger	barger	PROPN
fnp-3806	3343	6	s	s	PROPN
fnp-3806	3343	7	,	,	PUNCT
fnp-3806	3343	8	barnum	barnum	PROPN
fnp-3806	3343	9	s	s	PROPN
fnp-3806	3343	10	,	,	PUNCT
fnp-3806	3343	11	et	et	PROPN
fnp-3806	3343	12	al	al	PROPN
fnp-3806	3343	13	.	.	PROPN
fnp-3806	3344	1	inflammation	inflammation	PROPN
fnp-3806	3344	2	and	and	CCONJ
fnp-3806	3344	3	alzheimer	alzheimer	PROPN
fnp-3806	3344	4	’s	’s	PART
fnp-3806	3344	5	disease	disease	NOUN
fnp-3806	3344	6	.	.	PUNCT
fnp-3806	3345	1	neurobiol	neurobiol	PROPN
fnp-3806	3345	2	aging	age	VERB
fnp-3806	3345	3	2000;21:383	2000;21:383	PROPN
fnp-3806	3345	4	-	-	SYM
fnp-3806	3345	5	421	421	NUM
fnp-3806	3345	6	.	.	PUNCT
fnp-3806	3346	1	https://doi.org/10.1016/s0197-4580(00)00124-x	https://doi.org/10.1016/s0197-4580(00)00124-x	PROPN
fnp-3806	3346	2	streit	streit	PROPN
fnp-3806	3346	3	wj	wj	PROPN
fnp-3806	3346	4	,	,	PUNCT
fnp-3806	3346	5	conde	conde	PROPN
fnp-3806	3346	6	jr	jr	PROPN
fnp-3806	3346	7	,	,	PUNCT
fnp-3806	3346	8	harrison	harrison	PROPN
fnp-3806	3346	9	jk	jk	PROPN
fnp-3806	3346	10	.	.	PUNCT
fnp-3806	3347	1	chemokines	chemokine	NOUN
fnp-3806	3347	2	and	and	CCONJ
fnp-3806	3347	3	alzheimer	alzheimer	PROPN
fnp-3806	3347	4	’s	’s	PART
fnp-3806	3347	5	disease	disease	NOUN
fnp-3806	3347	6	.	.	PUNCT
fnp-3806	3348	1	neurobiol	neurobiol	PROPN
fnp-3806	3348	2	aging	age	VERB
fnp-3806	3348	3	2001;22:909	2001;22:909	NUM
fnp-3806	3348	4	-	-	SYM
fnp-3806	3348	5	913	913	NUM
fnp-3806	3348	6	.	.	PUNCT
fnp-3806	3349	1	https://doi.org/10.1016/s0197-4580(01)00290-1	https://doi.org/10.1016/s0197-4580(01)00290-1	PROPN
fnp-3806	3349	2	mcgeer	mcgeer	PROPN
fnp-3806	3349	3	eg	eg	PROPN
fnp-3806	3349	4	,	,	PUNCT
fnp-3806	3349	5	mcgeer	mcgeer	PROPN
fnp-3806	3349	6	pl	pl	PROPN
fnp-3806	3349	7	.	.	PROPN
fnp-3806	3349	8	neuroinflammation	neuroinflammation	PROPN
fnp-3806	3349	9	in	in	ADP
fnp-3806	3349	10	alzheimer	alzheimer	PROPN
fnp-3806	3349	11	’s	’s	PART
fnp-3806	3349	12	disease	disease	NOUN
fnp-3806	3349	13	and	and	CCONJ
fnp-3806	3349	14	mild	mild	ADJ
fnp-3806	3349	15	cognitive	cognitive	ADJ
fnp-3806	3349	16	impairment	impairment	NOUN
fnp-3806	3349	17	:	:	PUNCT
fnp-3806	3349	18	a	a	DET
fnp-3806	3349	19	field	field	NOUN
fnp-3806	3349	20	in	in	ADP
fnp-3806	3349	21	its	its	PRON
fnp-3806	3349	22	infancy	infancy	NOUN
fnp-3806	3349	23	.	.	PUNCT
fnp-3806	3350	1	j	j	PROPN
fnp-3806	3350	2	alzheimers	alzheimers	PROPN
fnp-3806	3350	3	dis	dis	PROPN
fnp-3806	3350	4	2010;19:355	2010;19:355	NUM
fnp-3806	3350	5	-	-	PUNCT
fnp-3806	3350	6	361	361	NUM
fnp-3806	3350	7	.	.	PUNCT
fnp-3806	3350	8	https://doi.org/10.3233/jad-2010-1219	https://doi.org/10.3233/jad-2010-1219	PROPN
fnp-3806	3350	9	morimoto	morimoto	PROPN
fnp-3806	3350	10	k	k	PROPN
fnp-3806	3350	11	,	,	PUNCT
fnp-3806	3350	12	horio	horio	PROPN
fnp-3806	3350	13	j	j	PROPN
fnp-3806	3350	14	,	,	PUNCT
fnp-3806	3350	15	satoh	satoh	NOUN
fnp-3806	3350	16	h	h	NOUN
fnp-3806	3350	17	,	,	PUNCT
fnp-3806	3350	18	et	et	PROPN
fnp-3806	3350	19	al	al	PROPN
fnp-3806	3350	20	.	.	PUNCT
fnp-3806	3351	1	expression	expression	NOUN
fnp-3806	3351	2	profiles	profile	NOUN
fnp-3806	3351	3	of	of	ADP
fnp-3806	3351	4	cytokines	cytokine	NOUN
fnp-3806	3351	5	in	in	ADP
fnp-3806	3351	6	the	the	DET
fnp-3806	3351	7	brains	brain	NOUN
fnp-3806	3351	8	of	of	ADP
fnp-3806	3351	9	alzheimer	alzheimer	PROPN
fnp-3806	3351	10	’s	’s	PART
fnp-3806	3351	11	disease	disease	NOUN
fnp-3806	3351	12	(	(	PUNCT
fnp-3806	3351	13	ad	ad	NOUN
fnp-3806	3351	14	)	)	PUNCT
fnp-3806	3351	15	patients	patient	NOUN
fnp-3806	3351	16	,	,	PUNCT
fnp-3806	3351	17	compared	compare	VERB
fnp-3806	3351	18	to	to	ADP
fnp-3806	3351	19	the	the	DET
fnp-3806	3351	20	brains	brain	NOUN
fnp-3806	3351	21	of	of	ADP
fnp-3806	3351	22	non	non	ADJ
fnp-3806	3351	23	-	-	ADJ
fnp-3806	3351	24	demented	demented	ADJ
fnp-3806	3351	25	patients	patient	NOUN
fnp-3806	3351	26	with	with	ADP
fnp-3806	3351	27	and	and	CCONJ
fnp-3806	3351	28	without	without	ADP
fnp-3806	3351	29	increasing	increase	VERB
fnp-3806	3351	30	ad	ad	NOUN
fnp-3806	3351	31	pathology	pathology	NOUN
fnp-3806	3351	32	.	.	PUNCT
fnp-3806	3352	1	j	j	PROPN
fnp-3806	3352	2	alzheimers	alzheimers	PROPN
fnp-3806	3352	3	dis	dis	PROPN
fnp-3806	3352	4	2011;25:59	2011;25:59	PROPN
fnp-3806	3352	5	-	-	SYM
fnp-3806	3352	6	76	76	NUM
fnp-3806	3352	7	.	.	PUNCT
fnp-3806	3353	1	https://doi.org/10.3233/jad-2011-101815	https://doi.org/10.3233/jad-2011-101815	PROPN
fnp-3806	3353	2	nagae	nagae	PROPN
fnp-3806	3353	3	t	t	PROPN
fnp-3806	3353	4	,	,	PUNCT
fnp-3806	3353	5	araki	araki	PROPN
fnp-3806	3353	6	k	k	PROPN
fnp-3806	3353	7	,	,	PUNCT
fnp-3806	3353	8	shimoda	shimoda	PROPN
fnp-3806	3353	9	y	y	PROPN
fnp-3806	3353	10	,	,	PUNCT
fnp-3806	3353	11	et	et	PROPN
fnp-3806	3353	12	al	al	PROPN
fnp-3806	3353	13	.	.	PUNCT
fnp-3806	3353	14	cytokines	cytokine	NOUN
fnp-3806	3353	15	and	and	CCONJ
fnp-3806	3353	16	cytokine	cytokine	ADJ
fnp-3806	3353	17	receptors	receptor	NOUN
fnp-3806	3353	18	involved	involve	VERB
fnp-3806	3353	19	in	in	ADP
fnp-3806	3353	20	the	the	DET
fnp-3806	3353	21	pathogenesis	pathogenesis	NOUN
fnp-3806	3353	22	of	of	ADP
fnp-3806	3353	23	alzheimer	alzheimer	PROPN
fnp-3806	3353	24	's	's	PART
fnp-3806	3353	25	disease	disease	NOUN
fnp-3806	3353	26	.	.	PUNCT
fnp-3806	3354	1	j	j	PROPN
fnp-3806	3354	2	clin	clin	PROPN
fnp-3806	3354	3	cell	cell	PROPN
fnp-3806	3354	4	immunol	immunol	PROPN
fnp-3806	3354	5	2016;7:441	2016;7:441	NUM
fnp-3806	3354	6	.	.	PUNCT
fnp-3806	3355	1	https://doi.org/10.4172/2155-9899.1000441	https://doi.org/10.4172/2155-9899.1000441	PROPN
fnp-3806	3355	2	prokop	prokop	PROPN
fnp-3806	3355	3	s	s	PROPN
fnp-3806	3355	4	,	,	PUNCT
fnp-3806	3355	5	miller	miller	PROPN
fnp-3806	3355	6	kr	kr	PROPN
fnp-3806	3355	7	,	,	PUNCT
fnp-3806	3355	8	heppner	heppner	PROPN
fnp-3806	3355	9	fl	fl	PROPN
fnp-3806	3355	10	.	.	PUNCT
fnp-3806	3356	1	microglia	microglia	ADJ
fnp-3806	3356	2	actions	action	NOUN
fnp-3806	3356	3	in	in	ADP
fnp-3806	3356	4	alzheimer	alzheimer	PROPN
fnp-3806	3356	5	’s	’s	PART
fnp-3806	3356	6	disease	disease	NOUN
fnp-3806	3356	7	.	.	PUNCT
fnp-3806	3357	1	acta	acta	PROPN
fnp-3806	3357	2	neuropathol	neuropathol	PROPN
fnp-3806	3357	3	2013;126:461	2013;126:461	PROPN
fnp-3806	3357	4	-	-	SYM
fnp-3806	3357	5	477	477	NUM
fnp-3806	3357	6	.	.	PUNCT
fnp-3806	3358	1	https://doi.org/10.1007/s00401-013-1182-x	https://doi.org/10.1007/s00401-013-1182-x	PROPN
fnp-3806	3358	2	heneka	heneka	PROPN
fnp-3806	3358	3	mt	mt	PROPN
fnp-3806	3358	4	,	,	PUNCT
fnp-3806	3358	5	kummer	kummer	PROPN
fnp-3806	3358	6	mp	mp	PROPN
fnp-3806	3358	7	,	,	PUNCT
fnp-3806	3358	8	latz	latz	ADJ
fnp-3806	3358	9	e.	e.	PROPN
fnp-3806	3358	10	innate	innate	ADJ
fnp-3806	3358	11	immune	immune	ADJ
fnp-3806	3358	12	activation	activation	NOUN
fnp-3806	3358	13	in	in	ADP
fnp-3806	3358	14	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3358	15	disease	disease	NOUN
fnp-3806	3358	16	.	.	PUNCT
fnp-3806	3359	1	nat	nat	PROPN
fnp-3806	3359	2	rev	rev	VERB
fnp-3806	3359	3	immunol	immunol	PROPN
fnp-3806	3359	4	2014;14:463	2014;14:463	PROPN
fnp-3806	3359	5	-	-	NOUN
fnp-3806	3359	6	477	477	NUM
fnp-3806	3359	7	.	.	PUNCT
fnp-3806	3360	1	https://doi.org/10.1038/nri3705	https://doi.org/10.1038/nri3705	NOUN
fnp-3806	3360	2	jorda	jorda	PROPN
fnp-3806	3360	3	a	a	PRON
fnp-3806	3360	4	,	,	PUNCT
fnp-3806	3360	5	campos	campos	PROPN
fnp-3806	3360	6	-	-	PUNCT
fnp-3806	3360	7	campos	campos	PROPN
fnp-3806	3360	8	j	j	PROPN
fnp-3806	3360	9	,	,	PUNCT
fnp-3806	3360	10	iradi	iradi	VERB
fnp-3806	3360	11	a	a	PRON
fnp-3806	3360	12	,	,	PUNCT
fnp-3806	3360	13	et	et	PROPN
fnp-3806	3360	14	al	al	PROPN
fnp-3806	3360	15	.	.	PUNCT
fnp-3806	3361	1	the	the	DET
fnp-3806	3361	2	role	role	NOUN
fnp-3806	3361	3	of	of	ADP
fnp-3806	3361	4	chemokines	chemokine	NOUN
fnp-3806	3361	5	in	in	ADP
fnp-3806	3361	6	alzheimer	alzheimer	PROPN
fnp-3806	3361	7	's	's	PART
fnp-3806	3361	8	disease	disease	NOUN
fnp-3806	3361	9	.	.	PUNCT
fnp-3806	3362	1	endocr	endocr	PROPN
fnp-3806	3362	2	metab	metab	PROPN
fnp-3806	3362	3	immune	immune	ADJ
fnp-3806	3362	4	disord	disord	NOUN
fnp-3806	3362	5	drug	drug	NOUN
fnp-3806	3362	6	targets	target	VERB
fnp-3806	3362	7	2020;20:1383	2020;20:1383	NUM
fnp-3806	3362	8	-	-	SYM
fnp-3806	3362	9	1390	1390	NUM
fnp-3806	3362	10	.	.	PUNCT
fnp-3806	3363	1	https://doi.org/10.2174/1871530320666200131110744	https://doi.org/10.2174/1871530320666200131110744	ADJ
fnp-3806	3363	2	lópez	lópez	NOUN
fnp-3806	3363	3	-	-	PUNCT
fnp-3806	3363	4	gonzález	gonzález	PROPN
fnp-3806	3363	5	i	i	PRON
fnp-3806	3363	6	,	,	PUNCT
fnp-3806	3363	7	schlüter	schlüter	ADJ
fnp-3806	3363	8	a	a	PRON
fnp-3806	3363	9	,	,	PUNCT
fnp-3806	3363	10	aso	aso	PROPN
fnp-3806	3363	11	e	e	PROPN
fnp-3806	3363	12	,	,	PUNCT
fnp-3806	3363	13	et	et	PROPN
fnp-3806	3363	14	al	al	PROPN
fnp-3806	3363	15	.	.	PUNCT
fnp-3806	3363	16	neuroinflammatory	neuroinflammatory	ADJ
fnp-3806	3363	17	signals	signal	NOUN
fnp-3806	3363	18	in	in	ADP
fnp-3806	3363	19	alzheimer	alzheimer	PROPN
fnp-3806	3363	20	disease	disease	NOUN
fnp-3806	3363	21	and	and	CCONJ
fnp-3806	3363	22	app	app	PROPN
fnp-3806	3363	23	/	/	SYM
fnp-3806	3363	24	ps1	ps1	NOUN
fnp-3806	3363	25	transgenic	transgenic	NOUN
fnp-3806	3363	26	mice	mouse	NOUN
fnp-3806	3363	27	:	:	PUNCT
fnp-3806	3363	28	correlations	correlation	NOUN
fnp-3806	3363	29	with	with	ADP
fnp-3806	3363	30	plaques	plaque	NOUN
fnp-3806	3363	31	,	,	PUNCT
fnp-3806	3363	32	tangles	tangle	NOUN
fnp-3806	3363	33	,	,	PUNCT
fnp-3806	3363	34	and	and	CCONJ
fnp-3806	3363	35	oligomeric	oligomeric	ADJ
fnp-3806	3363	36	species	specie	NOUN
fnp-3806	3363	37	.	.	PUNCT
fnp-3806	3364	1	j	j	PROPN
fnp-3806	3364	2	neuropathol	neuropathol	PROPN
fnp-3806	3364	3	exp	exp	PROPN
fnp-3806	3364	4	neurol	neurol	PROPN
fnp-3806	3364	5	2015;74	2015;74	NUM
fnp-3806	3364	6	:	:	PUNCT
fnp-3806	3364	7	319	319	NUM
fnp-3806	3364	8	-	-	SYM
fnp-3806	3364	9	344	344	NUM
fnp-3806	3364	10	.	.	PUNCT
fnp-3806	3365	1	https://doi.org/10.1097/nen.0000000000000176	https://doi.org/10.1097/nen.0000000000000176	PROPN
fnp-3806	3365	2	lópez	lópez	PROPN
fnp-3806	3365	3	-	-	PUNCT
fnp-3806	3365	4	gonzález	gonzález	PROPN
fnp-3806	3365	5	i	i	PROPN
fnp-3806	3365	6	,	,	PUNCT
fnp-3806	3365	7	aso	aso	PROPN
fnp-3806	3365	8	e	e	PROPN
fnp-3806	3365	9	,	,	PUNCT
fnp-3806	3365	10	carmona	carmona	PROPN
fnp-3806	3365	11	m	m	PROPN
fnp-3806	3365	12	,	,	PUNCT
fnp-3806	3365	13	et	et	PROPN
fnp-3806	3365	14	al	al	PROPN
fnp-3806	3365	15	.	.	PUNCT
fnp-3806	3365	16	neuroinflammatory	neuroinflammatory	ADJ
fnp-3806	3365	17	gene	gene	NOUN
fnp-3806	3365	18	regulation	regulation	NOUN
fnp-3806	3365	19	,	,	PUNCT
fnp-3806	3365	20	mitochondrial	mitochondrial	ADJ
fnp-3806	3365	21	function	function	NOUN
fnp-3806	3365	22	,	,	PUNCT
fnp-3806	3365	23	oxidative	oxidative	ADJ
fnp-3806	3365	24	stress	stress	NOUN
fnp-3806	3365	25	,	,	PUNCT
fnp-3806	3365	26	and	and	CCONJ
fnp-3806	3365	27	brain	brain	NOUN
fnp-3806	3365	28	lipid	lipid	NOUN
fnp-3806	3365	29	modifications	modification	NOUN
fnp-3806	3365	30	with	with	ADP
fnp-3806	3365	31	disease	disease	NOUN
fnp-3806	3365	32	progression	progression	NOUN
fnp-3806	3365	33	in	in	ADP
fnp-3806	3365	34	tau	tau	PROPN
fnp-3806	3365	35	p301s	p301s	NOUN
fnp-3806	3365	36	transgenic	transgenic	NOUN
fnp-3806	3365	37	mice	mouse	NOUN
fnp-3806	3365	38	as	as	ADP
fnp-3806	3365	39	a	a	DET
fnp-3806	3365	40	model	model	NOUN
fnp-3806	3365	41	of	of	ADP
fnp-3806	3365	42	frontotemporal	frontotemporal	ADJ
fnp-3806	3365	43	lobar	lobar	ADJ
fnp-3806	3365	44	degeneration	degeneration	NOUN
fnp-3806	3365	45	-	-	PUNCT
fnp-3806	3365	46	tau	tau	PROPN
fnp-3806	3365	47	.	.	PUNCT
fnp-3806	3366	1	j	j	PROPN
fnp-3806	3366	2	neuropathol	neuropathol	PROPN
fnp-3806	3366	3	exp	exp	PROPN
fnp-3806	3366	4	neurol	neurol	PROPN
fnp-3806	3366	5	2015;74	2015;74	NUM
fnp-3806	3366	6	:	:	PUNCT
fnp-3806	3366	7	975	975	NUM
fnp-3806	3366	8	-	-	SYM
fnp-3806	3366	9	999	999	NUM
fnp-3806	3366	10	.	.	PUNCT
fnp-3806	3367	1	https://doi.org/10.1097/nen.0000000000000241	https://doi.org/10.1097/nen.0000000000000241	PROPN
fnp-3806	3367	2	loving	love	VERB
fnp-3806	3367	3	ba	ba	PROPN
fnp-3806	3367	4	,	,	PUNCT
fnp-3806	3367	5	bruce	bruce	PROPN
fnp-3806	3367	6	kd	kd	PROPN
fnp-3806	3367	7	.	.	PROPN
fnp-3806	3367	8	lipid	lipid	PROPN
fnp-3806	3367	9	and	and	CCONJ
fnp-3806	3367	10	lipoprotein	lipoprotein	ADJ
fnp-3806	3367	11	metabolism	metabolism	NOUN
fnp-3806	3367	12	in	in	ADP
fnp-3806	3367	13	microglia	microglia	ADJ
fnp-3806	3367	14	.	.	PUNCT
fnp-3806	3368	1	front	front	ADJ
fnp-3806	3368	2	physiol	physiol	PROPN
fnp-3806	3368	3	.	.	PUNCT
fnp-3806	3369	1	2020;11:393	2020;11:393	NUM
fnp-3806	3369	2	.	.	PUNCT
fnp-3806	3370	1	https://doi.org/10.3389/fphys.2020.00393	https://doi.org/10.3389/fphys.2020.00393	PROPN
fnp-3806	3370	2	mcgeer	mcgeer	PROPN
fnp-3806	3370	3	pl	pl	PROPN
fnp-3806	3370	4	,	,	PUNCT
fnp-3806	3370	5	mcgeer	mcgeer	PROPN
fnp-3806	3370	6	eg	eg	NOUN
fnp-3806	3370	7	.	.	PUNCT
fnp-3806	3371	1	the	the	DET
fnp-3806	3371	2	amyloid	amyloid	NOUN
fnp-3806	3371	3	cascade	cascade	NOUN
fnp-3806	3371	4	/	/	SYM
fnp-3806	3371	5	inflammatory	inflammatory	ADJ
fnp-3806	3371	6	hypothesis	hypothesis	NOUN
fnp-3806	3371	7	of	of	ADP
fnp-3806	3371	8	alzheimer	alzheimer	PROPN
fnp-3806	3371	9	disease	disease	PROPN
fnp-3806	3371	10	:	:	PUNCT
fnp-3806	3371	11	implications	implication	NOUN
fnp-3806	3371	12	for	for	ADP
fnp-3806	3371	13	therapy	therapy	NOUN
fnp-3806	3371	14	.	.	PUNCT
fnp-3806	3372	1	acta	acta	PROPN
fnp-3806	3372	2	neuropathol	neuropathol	PROPN
fnp-3806	3372	3	2013;126:479	2013;126:479	PROPN
fnp-3806	3372	4	-	-	SYM
fnp-3806	3372	5	497	497	NUM
fnp-3806	3372	6	.	.	PUNCT
fnp-3806	3373	1	https://doi.org/10.1007/s00401-013-1177-7	https://doi.org/10.1007/s00401-013-1177-7	NUM
fnp-3806	3373	2	cai	cai	PROPN
fnp-3806	3374	1	z	z	PROPN
fnp-3806	3374	2	,	,	PUNCT
fnp-3806	3374	3	hussain	hussain	PROPN
fnp-3806	3374	4	md	md	PROPN
fnp-3806	3374	5	,	,	PUNCT
fnp-3806	3374	6	yan	yan	PROPN
fnp-3806	3374	7	lj	lj	PROPN
fnp-3806	3374	8	.	.	PUNCT
fnp-3806	3375	1	microglia	microglia	PROPN
fnp-3806	3375	2	,	,	PUNCT
fnp-3806	3375	3	neuroinflammation	neuroinflammation	NOUN
fnp-3806	3375	4	,	,	PUNCT
fnp-3806	3375	5	and	and	CCONJ
fnp-3806	3375	6	beta	beta	NOUN
fnp-3806	3375	7	-	-	PUNCT
fnp-3806	3375	8	amyloid	amyloid	NOUN
fnp-3806	3375	9	protein	protein	NOUN
fnp-3806	3375	10	in	in	ADP
fnp-3806	3375	11	alzheimer	alzheimer	PROPN
fnp-3806	3375	12	's	's	PART
fnp-3806	3375	13	disease	disease	NOUN
fnp-3806	3375	14	.	.	PUNCT
fnp-3806	3376	1	int	int	PROPN
fnp-3806	3376	2	j	j	PROPN
fnp-3806	3376	3	neurosci	neurosci	PROPN
fnp-3806	3376	4	2014;124:307	2014;124:307	NUM
fnp-3806	3376	5	-	-	SYM
fnp-3806	3376	6	321	321	NUM
fnp-3806	3376	7	.	.	PUNCT
fnp-3806	3377	1	https://doi.org/10.3109/00207454.2013.833510	https://doi.org/10.3109/00207454.2013.833510	NOUN
fnp-3806	3377	2	bamberger	bamberger	NOUN
fnp-3806	3377	3	me	i	PRON
fnp-3806	3377	4	,	,	PUNCT
fnp-3806	3377	5	harris	harris	PROPN
fnp-3806	3377	6	me	me	PROPN
fnp-3806	3377	7	,	,	PUNCT
fnp-3806	3377	8	mcdonald	mcdonald	PROPN
fnp-3806	3377	9	dr	dr	PROPN
fnp-3806	3377	10	,	,	PUNCT
fnp-3806	3377	11	et	et	PROPN
fnp-3806	3377	12	al	al	PROPN
fnp-3806	3377	13	.	.	PUNCT
fnp-3806	3378	1	a	a	DET
fnp-3806	3378	2	cell	cell	NOUN
fnp-3806	3378	3	surface	surface	NOUN
fnp-3806	3378	4	receptor	receptor	NOUN
fnp-3806	3378	5	complex	complex	NOUN
fnp-3806	3378	6	for	for	ADP
fnp-3806	3378	7	fibrillary	fibrillary	ADJ
fnp-3806	3378	8	-	-	PUNCT
fnp-3806	3378	9	amyloid	amyloid	NOUN
fnp-3806	3378	10	mediates	mediate	NOUN
fnp-3806	3378	11	microglial	microglial	ADJ
fnp-3806	3378	12	activation	activation	NOUN
fnp-3806	3378	13	.	.	PUNCT
fnp-3806	3379	1	j	j	PROPN
fnp-3806	3379	2	neurosci	neurosci	PROPN
fnp-3806	3379	3	2003;23:2665	2003;23:2665	NUM
fnp-3806	3379	4	-	-	SYM
fnp-3806	3379	5	2674	2674	NUM
fnp-3806	3379	6	.	.	PUNCT
fnp-3806	3380	1	https://doi.org/10.1523/jneurosci.23-07-02665.2003	https://doi.org/10.1523/jneurosci.23-07-02665.2003	X
fnp-3806	3380	2	mandrekar	mandrekar	NOUN
fnp-3806	3380	3	s	s	PART
fnp-3806	3380	4	,	,	PUNCT
fnp-3806	3380	5	jiang	jiang	PROPN
fnp-3806	3380	6	q	q	PROPN
fnp-3806	3380	7	,	,	PUNCT
fnp-3806	3380	8	lee	lee	PROPN
fnp-3806	3380	9	cy	cy	PROPN
fnp-3806	3380	10	,	,	PUNCT
fnp-3806	3380	11	et	et	PROPN
fnp-3806	3380	12	al	al	PROPN
fnp-3806	3380	13	.	.	PUNCT
fnp-3806	3381	1	microglia	microglia	PROPN
fnp-3806	3381	2	mediate	mediate	VERB
fnp-3806	3381	3	the	the	DET
fnp-3806	3381	4	clearance	clearance	NOUN
fnp-3806	3381	5	of	of	ADP
fnp-3806	3381	6	soluble	soluble	ADJ
fnp-3806	3381	7	aβ	aβ	NOUN
fnp-3806	3381	8	through	through	ADP
fnp-3806	3381	9	fluid	fluid	ADJ
fnp-3806	3381	10	phase	phase	NOUN
fnp-3806	3381	11	macropinocytosis	macropinocytosis	NOUN
fnp-3806	3381	12	.	.	PUNCT
fnp-3806	3382	1	j	j	PROPN
fnp-3806	3382	2	neurosci	neurosci	PROPN
fnp-3806	3382	3	2009;29:4252	2009;29:4252	NUM
fnp-3806	3382	4	-	-	SYM
fnp-3806	3382	5	4262	4262	NUM
fnp-3806	3382	6	.	.	PUNCT
fnp-3806	3383	1	https://doi.org/10.1523/jneurosci.5572-08.2009	https://doi.org/10.1523/jneurosci.5572-08.2009	PROPN
fnp-3806	3383	2	carroll	carroll	PROPN
fnp-3806	3383	3	mc	mc	PROPN
fnp-3806	3383	4	.	.	PUNCT
fnp-3806	3384	1	the	the	DET
fnp-3806	3384	2	complement	complement	NOUN
fnp-3806	3384	3	system	system	NOUN
fnp-3806	3384	4	in	in	ADP
fnp-3806	3384	5	b	b	PROPN
fnp-3806	3384	6	cell	cell	NOUN
fnp-3806	3384	7	regulation	regulation	NOUN
fnp-3806	3384	8	.	.	PUNCT
fnp-3806	3385	1	mol	mol	ADP
fnp-3806	3385	2	immunol	immunol	NOUN
fnp-3806	3385	3	2004;41:141	2004;41:141	PROPN
fnp-3806	3385	4	-	-	SYM
fnp-3806	3385	5	146	146	NUM
fnp-3806	3385	6	.	.	PUNCT
fnp-3806	3386	1	https://doi.org/10.1016/j.molimm.2004.03.017	https://doi.org/10.1016/j.molimm.2004.03.017	PRON
fnp-3806	3386	2	gasque	gasque	ADJ
fnp-3806	3386	3	p.	p.	NOUN
fnp-3806	3386	4	complement	complement	NOUN
fnp-3806	3386	5	:	:	PUNCT
fnp-3806	3386	6	a	a	DET
fnp-3806	3386	7	unique	unique	ADJ
fnp-3806	3386	8	innate	innate	ADJ
fnp-3806	3386	9	immune	immune	ADJ
fnp-3806	3386	10	sensor	sensor	NOUN
fnp-3806	3386	11	for	for	ADP
fnp-3806	3386	12	danger	danger	NOUN
fnp-3806	3386	13	signals	signal	NOUN
fnp-3806	3386	14	.	.	PUNCT
fnp-3806	3387	1	mol	mol	ADP
fnp-3806	3387	2	immunol	immunol	NOUN
fnp-3806	3387	3	2004;41:1089	2004;41:1089	PROPN
fnp-3806	3387	4	-	-	SYM
fnp-3806	3387	5	1098	1098	NUM
fnp-3806	3387	6	.	.	PUNCT
fnp-3806	3388	1	https://doi.org/10.1016/j.molimm.2004.06.011	https://doi.org/10.1016/j.molimm.2004.06.011	NUM
fnp-3806	3388	2	reichwald	reichwald	PROPN
fnp-3806	3388	3	j	j	PROPN
fnp-3806	3388	4	,	,	PUNCT
fnp-3806	3388	5	danner	danner	PROPN
fnp-3806	3388	6	s	s	PROPN
fnp-3806	3388	7	,	,	PUNCT
fnp-3806	3388	8	wiederhold	wiederhold	ADJ
fnp-3806	3388	9	kh	kh	PROPN
fnp-3806	3388	10	,	,	PUNCT
fnp-3806	3388	11	et	et	PROPN
fnp-3806	3388	12	al	al	PROPN
fnp-3806	3388	13	.	.	PUNCT
fnp-3806	3388	14	expression	expression	NOUN
fnp-3806	3388	15	of	of	ADP
fnp-3806	3388	16	complement	complement	NOUN
fnp-3806	3388	17	system	system	NOUN
fnp-3806	3388	18	components	component	NOUN
fnp-3806	3388	19	during	during	ADP
fnp-3806	3388	20	aging	age	VERB
fnp-3806	3388	21	and	and	CCONJ
fnp-3806	3388	22	amyloid	amyloid	NOUN
fnp-3806	3388	23	deposition	deposition	NOUN
fnp-3806	3388	24	in	in	ADP
fnp-3806	3388	25	app	app	NOUN
fnp-3806	3388	26	transgenic	transgenic	NOUN
fnp-3806	3388	27	mice	mouse	NOUN
fnp-3806	3388	28	.	.	PUNCT
fnp-3806	3389	1	j	j	PROPN
fnp-3806	3389	2	neuroinflammation	neuroinflammation	PROPN
fnp-3806	3389	3	2009	2009	NUM
fnp-3806	3389	4	;	;	PUNCT
fnp-3806	3389	5	6:35	6:35	NUM
fnp-3806	3389	6	.	.	PUNCT
fnp-3806	3390	1	https://doi.org/10.1186/1742-2094-6-35	https://doi.org/10.1186/1742-2094-6-35	PROPN
fnp-3806	3390	2	pan	pan	PROPN
fnp-3806	3390	3	xd	xd	PROPN
fnp-3806	3390	4	,	,	PUNCT
fnp-3806	3390	5	zhu	zhu	PROPN
fnp-3806	3390	6	yg	yg	PROPN
fnp-3806	3390	7	,	,	PUNCT
fnp-3806	3390	8	lin	lin	PROPN
fnp-3806	3390	9	n	n	CCONJ
fnp-3806	3390	10	,	,	PUNCT
fnp-3806	3390	11	et	et	PROPN
fnp-3806	3390	12	al	al	PROPN
fnp-3806	3390	13	.	.	PROPN
fnp-3806	3390	14	microglial	microglial	ADJ
fnp-3806	3390	15	phagocytosis	phagocytosis	NOUN
fnp-3806	3390	16	induced	induce	VERB
fnp-3806	3390	17	by	by	ADP
fnp-3806	3390	18	fibrillar	fibrillar	ADJ
fnp-3806	3390	19	β	β	NOUN
fnp-3806	3390	20	-	-	NOUN
fnp-3806	3390	21	amyloid	amyloid	NOUN
fnp-3806	3390	22	is	be	AUX
fnp-3806	3390	23	attenuated	attenuate	VERB
fnp-3806	3390	24	by	by	ADP
fnp-3806	3390	25	oligomeric	oligomeric	ADJ
fnp-3806	3390	26	β	β	NOUN
fnp-3806	3390	27	-	-	NOUN
fnp-3806	3390	28	amyloid	amyloid	NOUN
fnp-3806	3390	29	:	:	PUNCT
fnp-3806	3390	30	implications	implication	NOUN
fnp-3806	3390	31	for	for	ADP
fnp-3806	3390	32	alzheimer	alzheimer	PROPN
fnp-3806	3390	33	’s	’s	PART
fnp-3806	3390	34	disease	disease	NOUN
fnp-3806	3390	35	.	.	PUNCT
fnp-3806	3391	1	mol	mol	ADP
fnp-3806	3391	2	neurodegener	neurodegener	PROPN
fnp-3806	3391	3	2011;6:45	2011;6:45	PROPN
fnp-3806	3391	4	.	.	PUNCT
fnp-3806	3392	1	https://doi.org/10.1186/1750-1326-6-45	https://doi.org/10.1186/1750-1326-6-45	PROPN
fnp-3806	3392	2	vogels	vogels	PROPN
fnp-3806	3392	3	t	t	PROPN
fnp-3806	3392	4	,	,	PUNCT
fnp-3806	3392	5	murgoci	murgoci	PROPN
fnp-3806	3392	6	an	an	DET
fnp-3806	3392	7	,	,	PUNCT
fnp-3806	3392	8	hromádka	hromádka	NOUN
fnp-3806	3392	9	t.	t.	NOUN
fnp-3806	3392	10	intersection	intersection	NOUN
fnp-3806	3392	11	of	of	ADP
fnp-3806	3392	12	pathological	pathological	ADJ
fnp-3806	3392	13	tau	tau	NOUN
fnp-3806	3392	14	and	and	CCONJ
fnp-3806	3392	15	microglia	microglia	NOUN
fnp-3806	3392	16	at	at	ADP
fnp-3806	3392	17	the	the	DET
fnp-3806	3392	18	synapse	synapse	NOUN
fnp-3806	3392	19	.	.	PUNCT
fnp-3806	3393	1	acta	acta	PROPN
fnp-3806	3393	2	neuropathol	neuropathol	PROPN
fnp-3806	3393	3	commun	commun	PROPN
fnp-3806	3393	4	2019;7:109	2019;7:109	PROPN
fnp-3806	3393	5	.	.	PUNCT
fnp-3806	3394	1	https://doi.org/10.1186/s40478-019-0754-y	https://doi.org/10.1186/s40478-019-0754-y	PROPN
fnp-3806	3394	2	sheffield	sheffield	PROPN
fnp-3806	3394	3	lg	lg	PROPN
fnp-3806	3394	4	,	,	PUNCT
fnp-3806	3394	5	marquis	marquis	PROPN
fnp-3806	3394	6	jg	jg	PROPN
fnp-3806	3394	7	,	,	PUNCT
fnp-3806	3394	8	berman	berman	PROPN
fnp-3806	3394	9	ne	ne	PROPN
fnp-3806	3394	10	.	.	PUNCT
fnp-3806	3395	1	regional	regional	ADJ
fnp-3806	3395	2	distribution	distribution	NOUN
fnp-3806	3395	3	of	of	ADP
fnp-3806	3395	4	cortical	cortical	ADJ
fnp-3806	3395	5	microglia	microglia	NOUN
fnp-3806	3395	6	parallels	parallel	NOUN
fnp-3806	3395	7	that	that	SCONJ
fnp-3806	3395	8	of	of	ADP
fnp-3806	3395	9	neurofibrillary	neurofibrillary	ADJ
fnp-3806	3395	10	tangles	tangle	NOUN
fnp-3806	3395	11	in	in	ADP
fnp-3806	3395	12	alzheimer	alzheimer	PROPN
fnp-3806	3395	13	’s	’s	PART
fnp-3806	3395	14	disease	disease	NOUN
fnp-3806	3395	15	.	.	PUNCT
fnp-3806	3396	1	neurosci	neurosci	PROPN
fnp-3806	3396	2	lett	lett	PROPN
fnp-3806	3396	3	2000;285	2000;285	NUM
fnp-3806	3396	4	:	:	PUNCT
fnp-3806	3396	5	165	165	NUM
fnp-3806	3396	6	-	-	SYM
fnp-3806	3396	7	168	168	NUM
fnp-3806	3396	8	.	.	PUNCT
fnp-3806	3397	1	https://doi.org/10.1016/s0304-3940(00)01037-5	https://doi.org/10.1016/s0304-3940(00)01037-5	PROPN
fnp-3806	3397	2	serrano	serrano	PROPN
fnp-3806	3397	3	-	-	PUNCT
fnp-3806	3397	4	pozo	pozo	PROPN
fnp-3806	3397	5	a	a	X
fnp-3806	3397	6	,	,	PUNCT
fnp-3806	3397	7	mielke	mielke	ADJ
fnp-3806	3397	8	ml	ml	NOUN
fnp-3806	3397	9	,	,	PUNCT
fnp-3806	3397	10	gómez	gómez	PROPN
fnp-3806	3397	11	-	-	PUNCT
fnp-3806	3397	12	isla	isla	PROPN
fnp-3806	3397	13	t	t	PROPN
fnp-3806	3397	14	,	,	PUNCT
fnp-3806	3397	15	et	et	PROPN
fnp-3806	3397	16	al	al	PROPN
fnp-3806	3397	17	.	.	PROPN
fnp-3806	3397	18	reactive	reactive	ADJ
fnp-3806	3397	19	glia	glia	NOUN
fnp-3806	3397	20	not	not	PART
fnp-3806	3397	21	only	only	ADV
fnp-3806	3397	22	associates	associate	NOUN
fnp-3806	3397	23	with	with	ADP
fnp-3806	3397	24	plaques	plaque	NOUN
fnp-3806	3397	25	but	but	CCONJ
fnp-3806	3397	26	also	also	ADV
fnp-3806	3397	27	parallels	parallel	VERB
fnp-3806	3397	28	tangles	tangle	NOUN
fnp-3806	3397	29	in	in	ADP
fnp-3806	3397	30	alzheimer	alzheimer	PROPN
fnp-3806	3397	31	’s	’s	PART
fnp-3806	3397	32	disease	disease	NOUN
fnp-3806	3397	33	.	.	PUNCT
fnp-3806	3398	1	am	be	AUX
fnp-3806	3398	2	j	j	NOUN
fnp-3806	3398	3	pathol	pathol	NOUN
fnp-3806	3398	4	2011;179:1373	2011;179:1373	NUM
fnp-3806	3398	5	-	-	SYM
fnp-3806	3398	6	1384	1384	NUM
fnp-3806	3398	7	.	.	PUNCT
fnp-3806	3399	1	https://doi.org/10.1016/j.ajpath.2011.05.04	https://doi.org/10.1016/j.ajpath.2011.05.04	PROPN
fnp-3806	3399	2	perea	perea	PROPN
fnp-3806	3399	3	jr	jr	PROPN
fnp-3806	3399	4	,	,	PUNCT
fnp-3806	3399	5	bolós	bolós	NOUN
fnp-3806	3399	6	m	m	PROPN
fnp-3806	3399	7	,	,	PUNCT
fnp-3806	3399	8	avila	avila	PROPN
fnp-3806	3399	9	j.	j.	PROPN
fnp-3806	3399	10	microglia	microglia	PROPN
fnp-3806	3399	11	in	in	ADP
fnp-3806	3399	12	alzheimer	alzheimer	PROPN
fnp-3806	3399	13	’s	’s	PART
fnp-3806	3399	14	disease	disease	NOUN
fnp-3806	3399	15	in	in	ADP
fnp-3806	3399	16	the	the	DET
fnp-3806	3399	17	context	context	NOUN
fnp-3806	3399	18	of	of	ADP
fnp-3806	3399	19	tau	tau	PROPN
fnp-3806	3399	20	pathology	pathology	NOUN
fnp-3806	3399	21	.	.	PUNCT
fnp-3806	3400	1	biomolecules	biomolecule	NOUN
fnp-3806	3400	2	2020;10:1439	2020;10:1439	NUM
fnp-3806	3400	3	.	.	PUNCT
fnp-3806	3401	1	https://doi.org/10.3390/biom10101439	https://doi.org/10.3390/biom10101439	PROPN
fnp-3806	3401	2	zhou	zhou	PROPN
fnp-3806	3401	3	r	r	PROPN
fnp-3806	3401	4	,	,	PUNCT
fnp-3806	3401	5	ji	ji	PROPN
fnp-3806	3401	6	b	b	PROPN
fnp-3806	3401	7	,	,	PUNCT
fnp-3806	3401	8	kong	kong	PROPN
fnp-3806	3401	9	y	y	PROPN
fnp-3806	3401	10	,	,	PUNCT
fnp-3806	3401	11	et	et	PROPN
fnp-3806	3401	12	al	al	PROPN
fnp-3806	3401	13	.	.	PROPN
fnp-3806	3401	14	pet	pet	PROPN
fnp-3806	3401	15	imaging	imaging	NOUN
fnp-3806	3401	16	of	of	ADP
fnp-3806	3401	17	neuroinflammation	neuroinflammation	NOUN
fnp-3806	3401	18	in	in	ADP
fnp-3806	3401	19	alzheimer	alzheimer	PROPN
fnp-3806	3401	20	's	's	PART
fnp-3806	3401	21	disease	disease	NOUN
fnp-3806	3401	22	.	.	PUNCT
fnp-3806	3402	1	front	front	ADJ
fnp-3806	3402	2	immunol	immunol	NOUN
fnp-3806	3402	3	2021;12:739130	2021;12:739130	PROPN
fnp-3806	3402	4	.	.	PUNCT
fnp-3806	3403	1	https://doi.org/10.3389/fimmu.2021.739130	https://doi.org/10.3389/fimmu.2021.739130	PROPN
fnp-3806	3403	2	pascoal	pascoal	PROPN
fnp-3806	3403	3	ta	ta	PROPN
fnp-3806	3403	4	,	,	PUNCT
fnp-3806	3403	5	benedet	benedet	PROPN
fnp-3806	3403	6	al	al	PROPN
fnp-3806	3403	7	,	,	PUNCT
fnp-3806	3403	8	ashton	ashton	PROPN
fnp-3806	3403	9	nj	nj	PROPN
fnp-3806	3403	10	,	,	PUNCT
fnp-3806	3403	11	et	et	PROPN
fnp-3806	3403	12	al	al	PROPN
fnp-3806	3403	13	.	.	PROPN
fnp-3806	3403	14	microglial	microglial	ADJ
fnp-3806	3403	15	activation	activation	NOUN
fnp-3806	3403	16	and	and	CCONJ
fnp-3806	3403	17	tau	tau	PROPN
fnp-3806	3403	18	propagate	propagate	VERB
fnp-3806	3403	19	jointlyacross	jointlyacross	ADJ
fnp-3806	3403	20	braak	braak	NOUN
fnp-3806	3403	21	stages	stage	NOUN
fnp-3806	3403	22	.	.	PUNCT
fnp-3806	3404	1	nat	nat	PROPN
fnp-3806	3404	2	med	me	VERB
fnp-3806	3404	3	2021;27:1592	2021;27:1592	NUM
fnp-3806	3404	4	-	-	SYM
fnp-3806	3404	5	1599	1599	NUM
fnp-3806	3404	6	.	.	PUNCT
fnp-3806	3405	1	https://doi.org/10.1038/s41591-021-01456-w	https://doi.org/10.1038/s41591-021-01456-w	PROPN
fnp-3806	3405	2	vogels	vogels	PROPN
fnp-3806	3405	3	t	t	PROPN
fnp-3806	3405	4	,	,	PUNCT
fnp-3806	3405	5	leuzy	leuzy	VERB
fnp-3806	3405	6	a	a	DET
fnp-3806	3405	7	,	,	PUNCT
fnp-3806	3405	8	cicognola	cicognola	PROPN
fnp-3806	3405	9	c	c	X
fnp-3806	3405	10	,	,	PUNCT
fnp-3806	3405	11	et	et	PROPN
fnp-3806	3405	12	al	al	PROPN
fnp-3806	3405	13	.	.	PROPN
fnp-3806	3405	14	propagation	propagation	NOUN
fnp-3806	3405	15	of	of	ADP
fnp-3806	3405	16	tau	tau	PROPN
fnp-3806	3405	17	pathology	pathology	NOUN
fnp-3806	3405	18	:	:	PUNCT
fnp-3806	3405	19	integrating	integrate	VERB
fnp-3806	3405	20	insights	insight	NOUN
fnp-3806	3405	21	from	from	ADP
fnp-3806	3405	22	postmortem	postmortem	NOUN
fnp-3806	3405	23	and	and	CCONJ
fnp-3806	3405	24	in	in	ADP
fnp-3806	3405	25	vivo	vivo	ADJ
fnp-3806	3405	26	studies	study	NOUN
fnp-3806	3405	27	.	.	PUNCT
fnp-3806	3406	1	biol	biol	PROPN
fnp-3806	3406	2	psychiatry	psychiatry	NOUN
fnp-3806	3406	3	2020	2020	NUM
fnp-3806	3406	4	;	;	PUNCT
fnp-3806	3406	5	87	87	NUM
fnp-3806	3406	6	:	:	PUNCT
fnp-3806	3406	7	808	808	NUM
fnp-3806	3406	8	-	-	SYM
fnp-3806	3406	9	818	818	NUM
fnp-3806	3406	10	.	.	PUNCT
fnp-3806	3407	1	https://doi.org/10.1016/j.biopsych.2019.09.019	https://doi.org/10.1016/j.biopsych.2019.09.019	VERB
fnp-3806	3407	2	gerrits	gerrit	NOUN
fnp-3806	3407	3	e	e	PROPN
fnp-3806	3407	4	,	,	PUNCT
fnp-3806	3407	5	brouwer	brouwer	PROPN
fnp-3806	3407	6	n	n	CCONJ
fnp-3806	3407	7	,	,	PUNCT
fnp-3806	3407	8	kooistra	kooistra	PROPN
fnp-3806	3407	9	sm	sm	PROPN
fnp-3806	3407	10	,	,	PUNCT
fnp-3806	3407	11	et	et	PROPN
fnp-3806	3407	12	al	al	PROPN
fnp-3806	3407	13	.	.	PROPN
fnp-3806	3408	1	distinct	distinct	ADJ
fnp-3806	3408	2	amyloid	amyloid	NOUN
fnp-3806	3408	3	-	-	PUNCT
fnp-3806	3408	4	β	β	X
fnp-3806	3408	5	and	and	CCONJ
fnp-3806	3408	6	tau	tau	PROPN
fnp-3806	3408	7	-	-	PUNCT
fnp-3806	3408	8	associated	associate	VERB
fnp-3806	3408	9	microglia	microglia	ADJ
fnp-3806	3408	10	profiles	profile	NOUN
fnp-3806	3408	11	in	in	ADP
fnp-3806	3408	12	alzheimer	alzheimer	PROPN
fnp-3806	3408	13	's	's	PART
fnp-3806	3408	14	disease	disease	NOUN
fnp-3806	3408	15	.	.	PUNCT
fnp-3806	3409	1	acta	acta	PROPN
fnp-3806	3409	2	neuropathol	neuropathol	PROPN
fnp-3806	3409	3	2021;141:681	2021;141:681	NUM
fnp-3806	3409	4	-	-	SYM
fnp-3806	3409	5	696	696	NUM
fnp-3806	3409	6	.	.	PUNCT
fnp-3806	3410	1	https://doi.org/10.1007/s00401-021-02263-w	https://doi.org/10.1007/s00401-021-02263-w	PROPN
fnp-3806	3410	2	wilcock	wilcock	PROPN
fnp-3806	3410	3	dm	dm	PROPN
fnp-3806	3410	4	,	,	PUNCT
fnp-3806	3410	5	hurban	hurban	PROPN
fnp-3806	3410	6	j	j	PROPN
fnp-3806	3410	7	,	,	PUNCT
fnp-3806	3410	8	helman	helman	PROPN
fnp-3806	3410	9	am	am	PROPN
fnp-3806	3410	10	,	,	PUNCT
fnp-3806	3410	11	et	et	PROPN
fnp-3806	3410	12	al	al	PROPN
fnp-3806	3410	13	.	.	PROPN
fnp-3806	3411	1	down	down	ADP
fnp-3806	3411	2	syndrome	syndrome	NOUN
fnp-3806	3411	3	individuals	individual	NOUN
fnp-3806	3411	4	with	with	ADP
fnp-3806	3411	5	alzheimer	alzheimer	PROPN
fnp-3806	3411	6	's	's	PART
fnp-3806	3411	7	disease	disease	NOUN
fnp-3806	3411	8	have	have	VERB
fnp-3806	3411	9	a	a	DET
fnp-3806	3411	10	distinct	distinct	ADJ
fnp-3806	3411	11	neuroinflammatory	neuroinflammatory	ADJ
fnp-3806	3411	12	phenotype	phenotype	NOUN
fnp-3806	3411	13	compared	compare	VERB
fnp-3806	3411	14	to	to	ADP
fnp-3806	3411	15	sporadic	sporadic	ADJ
fnp-3806	3411	16	alzheimer	alzheimer	PROPN
fnp-3806	3411	17	's	's	PART
fnp-3806	3411	18	disease	disease	NOUN
fnp-3806	3411	19	.	.	PUNCT
fnp-3806	3412	1	neurobiol	neurobiol	PROPN
fnp-3806	3412	2	aging	age	VERB
fnp-3806	3412	3	2015;36:2468	2015;36:2468	NUM
fnp-3806	3412	4	-	-	PUNCT
fnp-3806	3412	5	2474	2474	NUM
fnp-3806	3412	6	.	.	PUNCT
fnp-3806	3413	1	https://doi.org/10.1016/j.neurobiolaging.2015.05.016	https://doi.org/10.1016/j.neurobiolaging.2015.05.016	PROPN
fnp-3806	3413	2	flores	flores	PROPN
fnp-3806	3413	3	-	-	PUNCT
fnp-3806	3413	4	aguilar	aguilar	PROPN
fnp-3806	3413	5	l	l	PROPN
fnp-3806	3413	6	,	,	PUNCT
fnp-3806	3413	7	iulita	iulita	PROPN
fnp-3806	3413	8	mf	mf	NOUN
fnp-3806	3413	9	,	,	PUNCT
fnp-3806	3413	10	kovecses	kovecse	VERB
fnp-3806	3413	11	o	o	PROPN
fnp-3806	3413	12	,	,	PUNCT
fnp-3806	3413	13	et	et	PROPN
fnp-3806	3413	14	al	al	PROPN
fnp-3806	3413	15	.	.	PROPN
fnp-3806	3413	16	evolution	evolution	NOUN
fnp-3806	3413	17	of	of	ADP
fnp-3806	3413	18	neuroinflammation	neuroinflammation	NOUN
fnp-3806	3413	19	across	across	ADP
fnp-3806	3413	20	the	the	DET
fnp-3806	3413	21	lifespan	lifespan	NOUN
fnp-3806	3413	22	of	of	ADP
fnp-3806	3413	23	individuals	individual	NOUN
fnp-3806	3413	24	with	with	ADP
fnp-3806	3413	25	down	down	ADP
fnp-3806	3413	26	syndrome	syndrome	NOUN
fnp-3806	3413	27	.	.	PUNCT
fnp-3806	3414	1	brain	brain	NOUN
fnp-3806	3414	2	2020;143:3653	2020;143:3653	NUM
fnp-3806	3414	3	-	-	SYM
fnp-3806	3414	4	3671	3671	NUM
fnp-3806	3414	5	.	.	PUNCT
fnp-3806	3415	1	https://doi.org/10.1093/brain/awaa326	https://doi.org/10.1093/brain/awaa326	PROPN
fnp-3806	3416	1	ahmed	ahmed	PROPN
fnp-3806	3416	2	mm	mm	PROPN
fnp-3806	3416	3	,	,	PUNCT
fnp-3806	3416	4	johnson	johnson	PROPN
fnp-3806	3416	5	nr	nr	PROPN
fnp-3806	3416	6	,	,	PUNCT
fnp-3806	3416	7	boyd	boyd	PROPN
fnp-3806	3416	8	td	td	PROPN
fnp-3806	3416	9	,	,	PUNCT
fnp-3806	3416	10	et	et	PROPN
fnp-3806	3416	11	al	al	PROPN
fnp-3806	3416	12	.	.	PROPN
fnp-3806	3416	13	innate	innate	ADJ
fnp-3806	3416	14	immune	immune	ADJ
fnp-3806	3416	15	system	system	NOUN
fnp-3806	3416	16	activation	activation	NOUN
fnp-3806	3416	17	and	and	CCONJ
fnp-3806	3416	18	neuroinflammation	neuroinflammation	NOUN
fnp-3806	3416	19	in	in	ADP
fnp-3806	3416	20	down	down	ADP
fnp-3806	3416	21	syndrome	syndrome	NOUN
fnp-3806	3416	22	and	and	CCONJ
fnp-3806	3416	23	neurodegeneration	neurodegeneration	NOUN
fnp-3806	3416	24	:	:	PUNCT
fnp-3806	3416	25	therapeutic	therapeutic	ADJ
fnp-3806	3416	26	targets	target	NOUN
fnp-3806	3416	27	or	or	CCONJ
fnp-3806	3416	28	partners	partner	NOUN
fnp-3806	3416	29	?	?	PUNCT
fnp-3806	3417	1	front	front	ADJ
fnp-3806	3417	2	aging	age	VERB
fnp-3806	3417	3	neurosci	neurosci	NOUN
fnp-3806	3417	4	2021;13:718426	2021;13:718426	NUM
fnp-3806	3417	5	.	.	PUNCT
fnp-3806	3418	1	https://doi.org/10.3389/fnagi.2021.718426	https://doi.org/10.3389/fnagi.2021.718426	PROPN
fnp-3806	3418	2	barroeta	barroeta	NOUN
fnp-3806	3418	3	-	-	PUNCT
fnp-3806	3418	4	espar	espar	NOUN
fnp-3806	3418	5	i	i	PROPN
fnp-3806	3418	6	,	,	PUNCT
fnp-3806	3418	7	weinstock	weinstock	PROPN
fnp-3806	3418	8	ld	ld	PROPN
fnp-3806	3418	9	,	,	PUNCT
fnp-3806	3418	10	perez	perez	PROPN
fnp-3806	3418	11	-	-	PUNCT
fnp-3806	3418	12	nievas	nievas	PROPN
fnp-3806	3418	13	bg	bg	PROPN
fnp-3806	3418	14	,	,	PUNCT
fnp-3806	3418	15	et	et	PROPN
fnp-3806	3418	16	al	al	PROPN
fnp-3806	3418	17	.	.	PROPN
fnp-3806	3418	18	distinct	distinct	ADJ
fnp-3806	3418	19	cytokine	cytokine	ADJ
fnp-3806	3418	20	profiles	profile	NOUN
fnp-3806	3418	21	in	in	ADP
fnp-3806	3418	22	human	human	ADJ
fnp-3806	3418	23	brains	brain	NOUN
fnp-3806	3418	24	resilient	resilient	ADJ
fnp-3806	3418	25	to	to	ADP
fnp-3806	3418	26	alzheimer	alzheimer	PROPN
fnp-3806	3418	27	’s	’s	PART
fnp-3806	3418	28	disease	disease	NOUN
fnp-3806	3418	29	.	.	PUNCT
fnp-3806	3419	1	neurobiol	neurobiol	PROPN
fnp-3806	3419	2	dis	dis	PROPN
fnp-3806	3419	3	2019;121:327	2019;121:327	NUM
fnp-3806	3419	4	-	-	SYM
fnp-3806	3419	5	337	337	NUM
fnp-3806	3419	6	.	.	PUNCT
fnp-3806	3420	1	https://doi.org/10.1016/j.nbd.2018.10.009	https://doi.org/10.1016/j.nbd.2018.10.009	PROPN
fnp-3806	3420	2	yang	yang	PROPN
fnp-3806	3420	3	j	j	PROPN
fnp-3806	3420	4	,	,	PUNCT
fnp-3806	3420	5	wise	wise	ADJ
fnp-3806	3420	6	l	l	NOUN
fnp-3806	3420	7	,	,	PUNCT
fnp-3806	3420	8	fukuchi	fukuchi	PROPN
fnp-3806	3420	9	ki	ki	PROPN
fnp-3806	3420	10	.	.	PUNCT
fnp-3806	3420	11	tlr4	tlr4	PROPN
fnp-3806	3420	12	cross	cross	NOUN
fnp-3806	3420	13	-	-	NOUN
fnp-3806	3420	14	talk	talk	NOUN
fnp-3806	3420	15	with	with	ADP
fnp-3806	3420	16	nlrp3	nlrp3	NOUN
fnp-3806	3420	17	inflammasome	inflammasome	NOUN
fnp-3806	3420	18	and	and	CCONJ
fnp-3806	3420	19	complement	complement	VERB
fnp-3806	3420	20	signaling	signal	VERB
fnp-3806	3420	21	pathways	pathway	NOUN
fnp-3806	3420	22	in	in	ADP
fnp-3806	3420	23	alzheimer	alzheimer	PROPN
fnp-3806	3420	24	's	's	PART
fnp-3806	3420	25	disease	disease	NOUN
fnp-3806	3420	26	.	.	PUNCT
fnp-3806	3421	1	front	front	ADJ
fnp-3806	3421	2	immunol	immunol	NOUN
fnp-3806	3421	3	2020;11:724	2020;11:724	X
fnp-3806	3421	4	.	.	PUNCT
fnp-3806	3422	1	https://doi.org/10.3389/fimmu.2020.00724	https://doi.org/10.3389/fimmu.2020.00724	PROPN
fnp-3806	3422	2	hanslik	hanslik	PROPN
fnp-3806	3422	3	kl	kl	PROPN
fnp-3806	3422	4	,	,	PUNCT
fnp-3806	3422	5	ulland	ulland	PROPN
fnp-3806	3422	6	tk	tk	PROPN
fnp-3806	3422	7	.	.	PUNCT
fnp-3806	3423	1	the	the	DET
fnp-3806	3423	2	role	role	NOUN
fnp-3806	3423	3	of	of	ADP
fnp-3806	3423	4	microglia	microglia	NOUN
fnp-3806	3423	5	and	and	CCONJ
fnp-3806	3423	6	the	the	DET
fnp-3806	3423	7	nlrp3	nlrp3	NOUN
fnp-3806	3423	8	inflammasome	inflammasome	NOUN
fnp-3806	3423	9	in	in	ADP
fnp-3806	3423	10	alzheimer	alzheimer	PROPN
fnp-3806	3423	11	's	's	PART
fnp-3806	3423	12	disease	disease	NOUN
fnp-3806	3423	13	.	.	PUNCT
fnp-3806	3424	1	front	front	ADJ
fnp-3806	3424	2	neurol	neurol	NOUN
fnp-3806	3424	3	2020;11:570711	2020;11:570711	NUM
fnp-3806	3424	4	.	.	PUNCT
fnp-3806	3425	1	https://doi.org/10.3389/fneur.2020.570711	https://doi.org/10.3389/fneur.2020.570711	PROPN
fnp-3806	3425	2	zhang	zhang	PROPN
fnp-3806	3425	3	y	y	PROPN
fnp-3806	3425	4	,	,	PUNCT
fnp-3806	3425	5	zhao	zhao	PROPN
fnp-3806	3425	6	y	y	PROPN
fnp-3806	3425	7	,	,	PUNCT
fnp-3806	3425	8	zhang	zhang	PROPN
fnp-3806	3425	9	j	j	PROPN
fnp-3806	3425	10	,	,	PUNCT
fnp-3806	3425	11	et	et	PROPN
fnp-3806	3425	12	al	al	PROPN
fnp-3806	3425	13	.	.	PROPN
fnp-3806	3425	14	mechanisms	mechanism	NOUN
fnp-3806	3425	15	of	of	ADP
fnp-3806	3425	16	nlrp3	nlrp3	NOUN
fnp-3806	3425	17	inflammasome	inflammasome	NOUN
fnp-3806	3425	18	activation	activation	NOUN
fnp-3806	3425	19	:	:	PUNCT
fnp-3806	3425	20	its	its	PRON
fnp-3806	3425	21	role	role	NOUN
fnp-3806	3425	22	in	in	ADP
fnp-3806	3425	23	the	the	DET
fnp-3806	3425	24	treatment	treatment	NOUN
fnp-3806	3425	25	of	of	ADP
fnp-3806	3425	26	alzheimer	alzheimer	PROPN
fnp-3806	3425	27	's	's	PART
fnp-3806	3425	28	disease	disease	NOUN
fnp-3806	3425	29	.	.	PUNCT
fnp-3806	3426	1	neurochem	neurochem	PROPN
fnp-3806	3426	2	res	re	VERB
fnp-3806	3426	3	2020;45:2560	2020;45:2560	PROPN
fnp-3806	3426	4	-	-	PUNCT
fnp-3806	3426	5	2572	2572	NUM
fnp-3806	3426	6	.	.	PUNCT
fnp-3806	3427	1	https://doi.org/10.1007/s11064-020-03121-z	https://doi.org/10.1007/s11064-020-03121-z	PROPN
fnp-3806	3427	2	halle	halle	PROPN
fnp-3806	3427	3	a	a	PROPN
fnp-3806	3427	4	,	,	PUNCT
fnp-3806	3427	5	hornung	hornung	ADJ
fnp-3806	3427	6	v	v	NOUN
fnp-3806	3427	7	,	,	PUNCT
fnp-3806	3427	8	petzold	petzold	PROPN
fnp-3806	3427	9	gc	gc	PROPN
fnp-3806	3427	10	,	,	PUNCT
fnp-3806	3427	11	et	et	PROPN
fnp-3806	3427	12	al	al	PROPN
fnp-3806	3427	13	.	.	PUNCT
fnp-3806	3428	1	the	the	DET
fnp-3806	3428	2	nalp3	nalp3	NOUN
fnp-3806	3428	3	inflammasome	inflammasome	NOUN
fnp-3806	3428	4	is	be	AUX
fnp-3806	3428	5	involved	involve	VERB
fnp-3806	3428	6	in	in	ADP
fnp-3806	3428	7	the	the	DET
fnp-3806	3428	8	innate	innate	ADJ
fnp-3806	3428	9	immune	immune	ADJ
fnp-3806	3428	10	response	response	NOUN
fnp-3806	3428	11	to	to	ADP
fnp-3806	3428	12	amyloid	amyloid	NOUN
fnp-3806	3428	13	-	-	PUNCT
fnp-3806	3428	14	beta	beta	NOUN
fnp-3806	3428	15	.	.	PUNCT
fnp-3806	3429	1	nat	nat	PROPN
fnp-3806	3429	2	immunol	immunol	PROPN
fnp-3806	3429	3	2008;9:857	2008;9:857	PROPN
fnp-3806	3429	4	-	-	SYM
fnp-3806	3429	5	865	865	NUM
fnp-3806	3429	6	.	.	PUNCT
fnp-3806	3430	1	https://doi.org/10.1038/ni.1636	https://doi.org/10.1038/ni.1636	NOUN
fnp-3806	3430	2	lučiūnaitė	lučiūnaitė	NOUN
fnp-3806	3430	3	a	a	PRON
fnp-3806	3430	4	,	,	PUNCT
fnp-3806	3430	5	mcmanus	mcmanus	PROPN
fnp-3806	3430	6	rm	rm	PROPN
fnp-3806	3430	7	,	,	PUNCT
fnp-3806	3430	8	jankunec	jankunec	PROPN
fnp-3806	3430	9	m	m	PROPN
fnp-3806	3430	10	,	,	PUNCT
fnp-3806	3430	11	et	et	PROPN
fnp-3806	3430	12	al	al	PROPN
fnp-3806	3430	13	.	.	PROPN
fnp-3806	3430	14	soluble	soluble	ADJ
fnp-3806	3430	15	aβ	aβ	NOUN
fnp-3806	3430	16	oligomers	oligomer	NOUN
fnp-3806	3430	17	and	and	CCONJ
fnp-3806	3430	18	protofibrils	protofibril	NOUN
fnp-3806	3430	19	induce	induce	VERB
fnp-3806	3430	20	nlrp3	nlrp3	NOUN
fnp-3806	3430	21	inflammasome	inflammasome	NOUN
fnp-3806	3430	22	activation	activation	NOUN
fnp-3806	3430	23	in	in	ADP
fnp-3806	3430	24	microglia	microglia	NOUN
fnp-3806	3430	25	.	.	PUNCT
fnp-3806	3431	1	j	j	PROPN
fnp-3806	3431	2	neurochem	neurochem	PROPN
fnp-3806	3431	3	2020;155:650	2020;155:650	PROPN
fnp-3806	3431	4	-	-	SYM
fnp-3806	3431	5	661	661	NUM
fnp-3806	3431	6	.	.	PUNCT
fnp-3806	3432	1	https://doi.org/10.1111/jnc.14945	https://doi.org/10.1111/jnc.14945	PROPN
fnp-3806	3432	2	van	van	PROPN
fnp-3806	3432	3	zeller	zeller	PROPN
fnp-3806	3432	4	m	m	PROPN
fnp-3806	3432	5	,	,	PUNCT
fnp-3806	3432	6	dias	dias	PROPN
fnp-3806	3432	7	d	d	PROPN
fnp-3806	3432	8	,	,	PUNCT
fnp-3806	3432	9	sebastião	sebastião	PROPN
fnp-3806	3432	10	am	be	AUX
fnp-3806	3432	11	,	,	PUNCT
fnp-3806	3432	12	et	et	PROPN
fnp-3806	3432	13	al	al	PROPN
fnp-3806	3432	14	.	.	PUNCT
fnp-3806	3433	1	nlrp3	nlrp3	PROPN
fnp-3806	3433	2	inflammasome	inflammasome	NOUN
fnp-3806	3433	3	:	:	PUNCT
fnp-3806	3433	4	a	a	DET
fnp-3806	3433	5	starring	star	VERB
fnp-3806	3433	6	role	role	NOUN
fnp-3806	3433	7	in	in	ADP
fnp-3806	3433	8	amyloid	amyloid	NOUN
fnp-3806	3433	9	-	-	PUNCT
fnp-3806	3433	10	βand	βand	NOUN
fnp-3806	3433	11	tau	tau	NOUN
fnp-3806	3433	12	-	-	PUNCT
fnp-3806	3433	13	driven	drive	VERB
fnp-3806	3433	14	pathological	pathological	ADJ
fnp-3806	3433	15	events	event	NOUN
fnp-3806	3433	16	in	in	ADP
fnp-3806	3433	17	alzheimer	alzheimer	PROPN
fnp-3806	3433	18	's	's	PART
fnp-3806	3433	19	disease	disease	NOUN
fnp-3806	3433	20	.	.	PUNCT
fnp-3806	3434	1	j	j	PROPN
fnp-3806	3434	2	alzheimers	alzheimers	PROPN
fnp-3806	3434	3	dis	dis	PROPN
fnp-3806	3434	4	2021;83:939	2021;83:939	NUM
fnp-3806	3434	5	-	-	SYM
fnp-3806	3434	6	961	961	NUM
fnp-3806	3434	7	.	.	PUNCT
fnp-3806	3435	1	https://doi.org/10.3233/jad-210268	https://doi.org/10.3233/jad-210268	PRON
fnp-3806	3435	2	heneka	heneka	PROPN
fnp-3806	3435	3	mt	mt	PROPN
fnp-3806	3435	4	,	,	PUNCT
fnp-3806	3435	5	kummer	kummer	PROPN
fnp-3806	3435	6	mp	mp	PROPN
fnp-3806	3435	7	,	,	PUNCT
fnp-3806	3435	8	stutz	stutz	VERB
fnp-3806	3435	9	a	a	PRON
fnp-3806	3435	10	,	,	PUNCT
fnp-3806	3435	11	et	et	PROPN
fnp-3806	3435	12	al	al	PROPN
fnp-3806	3435	13	.	.	PUNCT
fnp-3806	3436	1	nlrp3	nlrp3	PROPN
fnp-3806	3436	2	is	be	AUX
fnp-3806	3436	3	activated	activate	VERB
fnp-3806	3436	4	in	in	ADP
fnp-3806	3436	5	alzheimer	alzheimer	PROPN
fnp-3806	3436	6	's	's	PART
fnp-3806	3436	7	disease	disease	NOUN
fnp-3806	3436	8	and	and	CCONJ
fnp-3806	3436	9	contributes	contribute	VERB
fnp-3806	3436	10	to	to	ADP
fnp-3806	3436	11	pathology	pathology	NOUN
fnp-3806	3436	12	in	in	ADP
fnp-3806	3436	13	app	app	PROPN
fnp-3806	3436	14	/	/	SYM
fnp-3806	3436	15	ps1	ps1	NOUN
fnp-3806	3436	16	mice	mouse	NOUN
fnp-3806	3436	17	.	.	PUNCT
fnp-3806	3437	1	nature	nature	NOUN
fnp-3806	3437	2	2013;493:674	2013;493:674	NUM
fnp-3806	3437	3	-	-	SYM
fnp-3806	3437	4	678	678	NUM
fnp-3806	3437	5	.	.	PUNCT
fnp-3806	3438	1	https://doi.org/10.1038/nature11729	https://doi.org/10.1038/nature11729	PROPN
fnp-3806	3438	2	stancu	stancu	PROPN
fnp-3806	3438	3	ic	ic	PROPN
fnp-3806	3438	4	,	,	PUNCT
fnp-3806	3438	5	cremers	cremer	NOUN
fnp-3806	3438	6	n	n	CCONJ
fnp-3806	3438	7	,	,	PUNCT
fnp-3806	3438	8	vanrusselt	vanrusselt	VERB
fnp-3806	3438	9	h	h	NOUN
fnp-3806	3438	10	,	,	PUNCT
fnp-3806	3438	11	et	et	PROPN
fnp-3806	3438	12	al	al	PROPN
fnp-3806	3438	13	.	.	PROPN
fnp-3806	3438	14	aggregated	aggregate	VERB
fnp-3806	3438	15	tau	tau	PROPN
fnp-3806	3438	16	activates	activate	VERB
fnp-3806	3438	17	nlrp3	nlrp3	PROPN
fnp-3806	3438	18	-	-	PUNCT
fnp-3806	3438	19	asc	asc	PROPN
fnp-3806	3438	20	inflammasome	inflammasome	VERB
fnp-3806	3438	21	exacerbating	exacerbate	VERB
fnp-3806	3438	22	exogenously	exogenously	ADV
fnp-3806	3438	23	seeded	seeded	ADJ
fnp-3806	3438	24	and	and	CCONJ
fnp-3806	3438	25	non	non	ADJ
fnp-3806	3438	26	-	-	ADJ
fnp-3806	3438	27	exogenously	exogenously	ADV
fnp-3806	3438	28	seeded	seed	VERB
fnp-3806	3438	29	tau	tau	PROPN
fnp-3806	3438	30	pathology	pathology	NOUN
fnp-3806	3438	31	in	in	ADP
fnp-3806	3438	32	vivo	vivo	NOUN
fnp-3806	3438	33	.	.	PUNCT
fnp-3806	3439	1	acta	acta	PROPN
fnp-3806	3439	2	neuropathol	neuropathol	PROPN
fnp-3806	3439	3	2019;137:599	2019;137:599	NUM
fnp-3806	3439	4	-	-	SYM
fnp-3806	3439	5	617	617	NUM
fnp-3806	3439	6	.	.	PUNCT
fnp-3806	3440	1	https://doi.org/10.1007/s00401-018-01957-y	https://doi.org/10.1007/s00401-018-01957-y	PROPN
fnp-3806	3440	2	ising	ise	VERB
fnp-3806	3440	3	c	c	PROPN
fnp-3806	3440	4	,	,	PUNCT
fnp-3806	3440	5	venegas	venegas	PROPN
fnp-3806	3440	6	c	c	PROPN
fnp-3806	3440	7	,	,	PUNCT
fnp-3806	3440	8	zhang	zhang	PROPN
fnp-3806	3440	9	s	s	PROPN
fnp-3806	3440	10	,	,	PUNCT
fnp-3806	3440	11	et	et	PROPN
fnp-3806	3440	12	al	al	PROPN
fnp-3806	3440	13	.	.	PUNCT
fnp-3806	3441	1	nlrp3	nlrp3	PROPN
fnp-3806	3441	2	inflammasome	inflammasome	NOUN
fnp-3806	3441	3	activation	activation	NOUN
fnp-3806	3441	4	drives	drive	VERB
fnp-3806	3441	5	tau	tau	PROPN
fnp-3806	3441	6	pathology	pathology	PROPN
fnp-3806	3441	7	.	.	PUNCT
fnp-3806	3442	1	nature	nature	NOUN
fnp-3806	3442	2	2019;575:669	2019;575:669	NUM
fnp-3806	3442	3	-	-	SYM
fnp-3806	3442	4	673	673	NUM
fnp-3806	3442	5	.	.	PUNCT
fnp-3806	3443	1	https://doi.org/10.1038/s41586-019-1769-z	https://doi.org/10.1038/s41586-019-1769-z	PROPN
fnp-3806	3443	2	guerreiro	guerreiro	PROPN
fnp-3806	3443	3	r	r	PROPN
fnp-3806	3443	4	,	,	PUNCT
fnp-3806	3443	5	wojtas	wojta	NOUN
fnp-3806	3443	6	a	a	PRON
fnp-3806	3443	7	,	,	PUNCT
fnp-3806	3443	8	bras	bras	PROPN
fnp-3806	3443	9	j	j	PROPN
fnp-3806	3443	10	,	,	PUNCT
fnp-3806	3443	11	et	et	PROPN
fnp-3806	3443	12	al	al	PROPN
fnp-3806	3443	13	.	.	PUNCT
fnp-3806	3444	1	trem2	trem2	PROPN
fnp-3806	3444	2	variants	variant	NOUN
fnp-3806	3444	3	in	in	ADP
fnp-3806	3444	4	alzheimer	alzheimer	PROPN
fnp-3806	3444	5	’s	’s	PART
fnp-3806	3444	6	disease	disease	NOUN
fnp-3806	3444	7	.	.	PUNCT
fnp-3806	3445	1	n	n	PROPN
fnp-3806	3445	2	engl	engl	PROPN
fnp-3806	3445	3	j	j	PROPN
fnp-3806	3445	4	med	med	PROPN
fnp-3806	3445	5	2013;368:117	2013;368:117	NUM
fnp-3806	3445	6	-	-	SYM
fnp-3806	3445	7	127	127	NUM
fnp-3806	3445	8	.	.	PUNCT
fnp-3806	3446	1	https://doi.org/10.1056/nejmoa1211851	https://doi.org/10.1056/nejmoa1211851	NOUN
fnp-3806	3446	2	takatori	takatori	PROPN
fnp-3806	3446	3	s	s	PROPN
fnp-3806	3446	4	,	,	PUNCT
fnp-3806	3446	5	wang	wang	PROPN
fnp-3806	3446	6	w	w	PROPN
fnp-3806	3446	7	,	,	PUNCT
fnp-3806	3446	8	iguchi	iguchi	ADJ
fnp-3806	3446	9	a	a	PRON
fnp-3806	3446	10	,	,	PUNCT
fnp-3806	3446	11	tomita	tomita	PROPN
fnp-3806	3446	12	t.	t.	PROPN
fnp-3806	3446	13	genetic	genetic	ADJ
fnp-3806	3446	14	risk	risk	NOUN
fnp-3806	3446	15	factors	factor	NOUN
fnp-3806	3446	16	for	for	ADP
fnp-3806	3446	17	alzheimer	alzheimer	NOUN
fnp-3806	3446	18	disease	disease	NOUN
fnp-3806	3446	19	:	:	PUNCT
fnp-3806	3446	20	emerging	emerge	VERB
fnp-3806	3446	21	roles	role	NOUN
fnp-3806	3446	22	of	of	ADP
fnp-3806	3446	23	microglia	microglia	NOUN
fnp-3806	3446	24	in	in	ADP
fnp-3806	3446	25	disease	disease	NOUN
fnp-3806	3446	26	pathomechanisms	pathomechanism	NOUN
fnp-3806	3446	27	.	.	PUNCT
fnp-3806	3447	1	adv	adv	PROPN
fnp-3806	3447	2	exp	exp	NUM
fnp-3806	3447	3	med	med	ADJ
fnp-3806	3447	4	biol	biol	NOUN
fnp-3806	3447	5	2019;1118:83	2019;1118:83	NUM
fnp-3806	3447	6	-	-	SYM
fnp-3806	3447	7	116	116	NUM
fnp-3806	3447	8	.	.	PUNCT
fnp-3806	3447	9	https://doi.org/10.1007/978-3-030-05542-4_5	https://doi.org/10.1007/978-3-030-05542-4_5	PROPN
fnp-3806	3448	1	leng	leng	PROPN
fnp-3806	3448	2	f	f	PROPN
fnp-3806	3448	3	,	,	PUNCT
fnp-3806	3448	4	edison	edison	PROPN
fnp-3806	3448	5	p.	p.	NOUN
fnp-3806	3448	6	neuroinflammation	neuroinflammation	PROPN
fnp-3806	3448	7	and	and	CCONJ
fnp-3806	3448	8	microglial	microglial	ADJ
fnp-3806	3448	9	activation	activation	NOUN
fnp-3806	3448	10	in	in	ADP
fnp-3806	3448	11	alzheimer	alzheimer	PROPN
fnp-3806	3448	12	disease	disease	PROPN
fnp-3806	3448	13	:	:	PUNCT
fnp-3806	3448	14	where	where	SCONJ
fnp-3806	3448	15	do	do	AUX
fnp-3806	3448	16	we	we	PRON
fnp-3806	3448	17	go	go	VERB
fnp-3806	3448	18	from	from	ADP
fnp-3806	3448	19	here	here	ADV
fnp-3806	3448	20	?	?	PUNCT
fnp-3806	3449	1	nat	nat	PROPN
fnp-3806	3449	2	rev	rev	VERB
fnp-3806	3449	3	neurol	neurol	PROPN
fnp-3806	3449	4	2021;17:157	2021;17:157	PROPN
fnp-3806	3449	5	-	-	SYM
fnp-3806	3449	6	172	172	NUM
fnp-3806	3449	7	.	.	PUNCT
fnp-3806	3450	1	https://doi.org/10.1038/s41582-020-00435-y	https://doi.org/10.1038/s41582-020-00435-y	PROPN
fnp-3806	3450	2	egensperger	egensperger	PROPN
fnp-3806	3450	3	r	r	NOUN
fnp-3806	3450	4	,	,	PUNCT
fnp-3806	3450	5	kösel	kösel	NOUN
fnp-3806	3450	6	s	s	PROPN
fnp-3806	3450	7	,	,	PUNCT
fnp-3806	3450	8	von	von	PROPN
fnp-3806	3450	9	eitzen	eitzen	PROPN
fnp-3806	3450	10	u	u	PROPN
fnp-3806	3450	11	,	,	PUNCT
fnp-3806	3450	12	et	et	PROPN
fnp-3806	3450	13	al	al	PROPN
fnp-3806	3450	14	.	.	PROPN
fnp-3806	3450	15	microglial	microglial	ADJ
fnp-3806	3450	16	activation	activation	NOUN
fnp-3806	3450	17	in	in	ADP
fnp-3806	3450	18	alzheimer	alzheimer	PROPN
fnp-3806	3450	19	disease	disease	PROPN
fnp-3806	3450	20	:	:	PUNCT
fnp-3806	3450	21	association	association	NOUN
fnp-3806	3450	22	with	with	ADP
fnp-3806	3450	23	apoe	apoe	ADJ
fnp-3806	3450	24	genotype	genotype	NOUN
fnp-3806	3450	25	.	.	PUNCT
fnp-3806	3451	1	brain	brain	NOUN
fnp-3806	3451	2	pathol	pathol	PROPN
fnp-3806	3451	3	1998;8:439	1998;8:439	PROPN
fnp-3806	3451	4	-	-	SYM
fnp-3806	3451	5	447	447	NUM
fnp-3806	3451	6	.	.	PUNCT
fnp-3806	3452	1	https://doi.org/10.1111/j.1750-3639.1998.tb00166.x	https://doi.org/10.1111/j.1750-3639.1998.tb00166.x	VERB
fnp-3806	3452	2	kloske	kloske	ADJ
fnp-3806	3452	3	cm	cm	PROPN
fnp-3806	3452	4	,	,	PUNCT
fnp-3806	3452	5	dugan	dugan	PROPN
fnp-3806	3452	6	aj	aj	PROPN
fnp-3806	3452	7	,	,	PUNCT
fnp-3806	3452	8	weekman	weekman	VERB
fnp-3806	3452	9	em	em	PRON
fnp-3806	3452	10	,	,	PUNCT
fnp-3806	3452	11	et	et	PROPN
fnp-3806	3452	12	al	al	PROPN
fnp-3806	3452	13	.	.	PUNCT
fnp-3806	3453	1	inflammatory	inflammatory	ADJ
fnp-3806	3453	2	pathways	pathway	NOUN
fnp-3806	3453	3	are	be	AUX
fnp-3806	3453	4	impaired	impair	VERB
fnp-3806	3453	5	in	in	ADP
fnp-3806	3453	6	alzheimer	alzheimer	NOUN
fnp-3806	3453	7	disease	disease	NOUN
fnp-3806	3453	8	and	and	CCONJ
fnp-3806	3453	9	differentially	differentially	ADV
fnp-3806	3453	10	associated	associate	VERB
fnp-3806	3453	11	with	with	ADP
fnp-3806	3453	12	apolipoprotein	apolipoprotein	ADJ
fnp-3806	3453	13	e	e	PROPN
fnp-3806	3453	14	status	status	NOUN
fnp-3806	3453	15	.	.	PUNCT
fnp-3806	3454	1	j	j	PROPN
fnp-3806	3454	2	neuropathol	neuropathol	PROPN
fnp-3806	3454	3	exp	exp	PROPN
fnp-3806	3454	4	neuro	neuro	PROPN
fnp-3806	3454	5	2021	2021	NUM
fnp-3806	3454	6	;	;	PUNCT
fnp-3806	3454	7	80	80	NUM
fnp-3806	3454	8	:	:	PUNCT
fnp-3806	3454	9	922	922	NUM
fnp-3806	3454	10	-	-	SYM
fnp-3806	3454	11	932	932	NUM
fnp-3806	3454	12	.	.	PUNCT
fnp-3806	3455	1	https://doi.org/10.1093/jnen/nlab085	https://doi.org/10.1093/jnen/nlab085	PROPN
fnp-3806	3455	2	singh	singh	PROPN
fnp-3806	3455	3	ak	ak	PROPN
fnp-3806	3455	4	,	,	PUNCT
fnp-3806	3455	5	mishra	mishra	PROPN
fnp-3806	3455	6	g	g	PROPN
fnp-3806	3455	7	,	,	PUNCT
fnp-3806	3455	8	maurya	maurya	PROPN
fnp-3806	3455	9	a	a	PROPN
fnp-3806	3455	10	,	,	PUNCT
fnp-3806	3455	11	et	et	PROPN
fnp-3806	3455	12	al	al	PROPN
fnp-3806	3455	13	.	.	PUNCT
fnp-3806	3455	14	role	role	NOUN
fnp-3806	3455	15	of	of	ADP
fnp-3806	3455	16	trem2	trem2	NOUN
fnp-3806	3455	17	in	in	ADP
fnp-3806	3455	18	alzheimer	alzheimer	PROPN
fnp-3806	3455	19	's	's	PART
fnp-3806	3455	20	disease	disease	NOUN
fnp-3806	3455	21	and	and	CCONJ
fnp-3806	3455	22	its	its	PRON
fnp-3806	3455	23	consequences	consequence	NOUN
fnp-3806	3455	24	on	on	ADP
fnp-3806	3455	25	β	β	NOUN
fnp-3806	3455	26	-	-	NOUN
fnp-3806	3455	27	amyloid	amyloid	NOUN
fnp-3806	3455	28	,	,	PUNCT
fnp-3806	3455	29	tau	tau	PROPN
fnp-3806	3455	30	and	and	CCONJ
fnp-3806	3455	31	neurofibrillary	neurofibrillary	ADJ
fnp-3806	3455	32	tangles	tangle	NOUN
fnp-3806	3455	33	.	.	PUNCT
fnp-3806	3456	1	curr	curr	PROPN
fnp-3806	3456	2	alzheimer	alzheimer	PROPN
fnp-3806	3456	3	res	res	PROPN
fnp-3806	3456	4	2019;16:1216	2019;16:1216	NUM
fnp-3806	3456	5	-	-	SYM
fnp-3806	3456	6	1229	1229	NUM
fnp-3806	3456	7	.	.	PUNCT
fnp-3806	3457	1	https://doi.org/10.2174/1567205016666190903102822	https://doi.org/10.2174/1567205016666190903102822	NOUN
fnp-3806	3457	2	griciuc	griciuc	VERB
fnp-3806	3457	3	a	a	PRON
fnp-3806	3457	4	,	,	PUNCT
fnp-3806	3457	5	tanzi	tanzi	X
fnp-3806	3457	6	re	re	PROPN
fnp-3806	3457	7	.	.	PUNCT
fnp-3806	3458	1	the	the	DET
fnp-3806	3458	2	role	role	NOUN
fnp-3806	3458	3	of	of	ADP
fnp-3806	3458	4	innate	innate	ADJ
fnp-3806	3458	5	immune	immune	ADJ
fnp-3806	3458	6	genes	gene	NOUN
fnp-3806	3458	7	in	in	ADP
fnp-3806	3458	8	alzheimer	alzheimer	PROPN
fnp-3806	3458	9	’s	’s	PART
fnp-3806	3458	10	disease	disease	NOUN
fnp-3806	3458	11	.	.	PUNCT
fnp-3806	3459	1	curr	curr	PROPN
fnp-3806	3459	2	opin	opin	PROPN
fnp-3806	3459	3	neurol	neurol	PROPN
fnp-3806	3459	4	2021;34	2021;34	NUM
fnp-3806	3459	5	:	:	PUNCT
fnp-3806	3459	6	228	228	NUM
fnp-3806	3459	7	-	-	SYM
fnp-3806	3459	8	236	236	NUM
fnp-3806	3459	9	.	.	PUNCT
fnp-3806	3460	1	https://doi.org/10.1097/wco.0000000000000911	https://doi.org/10.1097/wco.0000000000000911	PROPN
fnp-3806	3460	2	prokop	prokop	PROPN
fnp-3806	3460	3	s	s	PROPN
fnp-3806	3460	4	,	,	PUNCT
fnp-3806	3460	5	miller	miller	PROPN
fnp-3806	3460	6	kr	kr	PROPN
fnp-3806	3460	7	,	,	PUNCT
fnp-3806	3460	8	labra	labra	PROPN
fnp-3806	3460	9	sr	sr	PROPN
fnp-3806	3460	10	,	,	PUNCT
fnp-3806	3460	11	et	et	PROPN
fnp-3806	3460	12	al	al	PROPN
fnp-3806	3460	13	.	.	PROPN
fnp-3806	3460	14	impact	impact	NOUN
fnp-3806	3460	15	of	of	ADP
fnp-3806	3460	16	trem2	trem2	NOUN
fnp-3806	3460	17	risk	risk	NOUN
fnp-3806	3460	18	variants	variant	NOUN
fnp-3806	3460	19	on	on	ADP
fnp-3806	3460	20	brain	brain	NOUN
fnp-3806	3460	21	region	region	NOUN
fnp-3806	3460	22	-	-	PUNCT
fnp-3806	3460	23	specific	specific	ADJ
fnp-3806	3460	24	immune	immune	ADJ
fnp-3806	3460	25	activation	activation	NOUN
fnp-3806	3460	26	and	and	CCONJ
fnp-3806	3460	27	plaque	plaque	NOUN
fnp-3806	3460	28	microenvironment	microenvironment	NOUN
fnp-3806	3460	29	in	in	ADP
fnp-3806	3460	30	alzheimer	alzheimer	PROPN
fnp-3806	3460	31	's	's	PART
fnp-3806	3460	32	disease	disease	NOUN
fnp-3806	3460	33	patient	patient	NOUN
fnp-3806	3460	34	brain	brain	NOUN
fnp-3806	3460	35	samples	sample	NOUN
fnp-3806	3460	36	.	.	PUNCT
fnp-3806	3461	1	acta	acta	PROPN
fnp-3806	3461	2	neuropathol	neuropathol	PROPN
fnp-3806	3461	3	2019;138:613	2019;138:613	NUM
fnp-3806	3461	4	-	-	SYM
fnp-3806	3461	5	630	630	NUM
fnp-3806	3461	6	.	.	PUNCT
fnp-3806	3461	7	https://doi.org/10.1007/s00401-019-02048-2	https://doi.org/10.1007/s00401-019-02048-2	VERB
fnp-3806	3461	8	toomey	toomey	PROPN
fnp-3806	3461	9	ce	ce	PROPN
fnp-3806	3461	10	,	,	PUNCT
fnp-3806	3461	11	heywood	heywood	PROPN
fnp-3806	3461	12	w	w	PROPN
fnp-3806	3461	13	,	,	PUNCT
fnp-3806	3461	14	benson	benson	PROPN
fnp-3806	3461	15	bc	bc	PROPN
fnp-3806	3461	16	,	,	PUNCT
fnp-3806	3461	17	et	et	PROPN
fnp-3806	3461	18	al	al	PROPN
fnp-3806	3461	19	.	.	PROPN
fnp-3806	3461	20	investigation	investigation	NOUN
fnp-3806	3461	21	of	of	ADP
fnp-3806	3461	22	pathology	pathology	NOUN
fnp-3806	3461	23	,	,	PUNCT
fnp-3806	3461	24	expression	expression	NOUN
fnp-3806	3461	25	and	and	CCONJ
fnp-3806	3461	26	proteomic	proteomic	ADJ
fnp-3806	3461	27	profiles	profile	NOUN
fnp-3806	3461	28	in	in	ADP
fnp-3806	3461	29	human	human	ADJ
fnp-3806	3461	30	trem2	trem2	NOUN
fnp-3806	3461	31	variant	variant	NOUN
fnp-3806	3461	32	postmortem	postmortem	NOUN
fnp-3806	3461	33	brains	brain	NOUN
fnp-3806	3461	34	with	with	ADP
fnp-3806	3461	35	and	and	CCONJ
fnp-3806	3461	36	without	without	ADP
fnp-3806	3461	37	alzheimer	alzheimer	PROPN
fnp-3806	3461	38	's	's	PART
fnp-3806	3461	39	disease	disease	NOUN
fnp-3806	3461	40	.	.	PUNCT
fnp-3806	3462	1	brain	brain	NOUN
fnp-3806	3462	2	pathol	pathol	NOUN
fnp-3806	3462	3	2020;30:794	2020;30:794	NUM
fnp-3806	3462	4	-	-	SYM
fnp-3806	3462	5	810	810	NUM
fnp-3806	3462	6	.	.	PUNCT
fnp-3806	3463	1	https://doi.org/10.1111/bpa.12842	https://doi.org/10.1111/bpa.12842	PROPN
fnp-3806	3463	2	ferrer	ferrer	PROPN
fnp-3806	3463	3	i.	i.	PROPN
fnp-3806	3463	4	oligodendrogliopathy	oligodendrogliopathy	PROPN
fnp-3806	3463	5	in	in	ADP
fnp-3806	3463	6	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3463	7	diseases	disease	NOUN
fnp-3806	3463	8	with	with	ADP
fnp-3806	3463	9	abnormal	abnormal	ADJ
fnp-3806	3463	10	protein	protein	NOUN
fnp-3806	3463	11	aggregates	aggregate	NOUN
fnp-3806	3463	12	:	:	PUNCT
fnp-3806	3463	13	the	the	DET
fnp-3806	3463	14	forgotten	forget	VERB
fnp-3806	3463	15	pattern	pattern	NOUN
fnp-3806	3463	16	.	.	PUNCT
fnp-3806	3464	1	prog	prog	PROPN
fnp-3806	3464	2	neurobiol	neurobiol	PROPN
fnp-3806	3464	3	2018;169:24	2018;169:24	NUM
fnp-3806	3464	4	-	-	SYM
fnp-3806	3464	5	54	54	NUM
fnp-3806	3464	6	.	.	PUNCT
fnp-3806	3465	1	https://doi.org/10.1016/j.pneurobio.2018.07.004	https://doi.org/10.1016/j.pneurobio.2018.07.004	PROPN
fnp-3806	3465	2	hachinski	hachinski	PROPN
fnp-3806	3465	3	vc	vc	PROPN
fnp-3806	3465	4	,	,	PUNCT
fnp-3806	3465	5	potter	potter	NOUN
fnp-3806	3465	6	p	p	NOUN
fnp-3806	3465	7	,	,	PUNCT
fnp-3806	3465	8	merskey	merskey	PROPN
fnp-3806	3465	9	h.	h.	PROPN
fnp-3806	3465	10	leuko	leuko	PROPN
fnp-3806	3465	11	-	-	PUNCT
fnp-3806	3465	12	araiosis	araiosis	NOUN
fnp-3806	3465	13	.	.	PUNCT
fnp-3806	3466	1	arch	arch	ADJ
fnp-3806	3466	2	neurol	neurol	PROPN
fnp-3806	3466	3	1987;44:21	1987;44:21	NUM
fnp-3806	3466	4	-	-	SYM
fnp-3806	3466	5	23	23	NUM
fnp-3806	3466	6	.	.	PUNCT
fnp-3806	3467	1	https://doi.org/10.1001/archneur.1987.00520130013009	https://doi.org/10.1001/archneur.1987.00520130013009	PROPN
fnp-3806	3467	2	scheltens	schelten	VERB
fnp-3806	3467	3	p	p	NOUN
fnp-3806	3467	4	,	,	PUNCT
fnp-3806	3467	5	barkhof	barkhof	NOUN
fnp-3806	3467	6	f	f	PROPN
fnp-3806	3467	7	,	,	PUNCT
fnp-3806	3467	8	leys	leys	PROPN
fnp-3806	3467	9	d	d	PROPN
fnp-3806	3467	10	,	,	PUNCT
fnp-3806	3468	1	et	et	PROPN
fnp-3806	3468	2	al	al	PROPN
fnp-3806	3468	3	.	.	PROPN
fnp-3806	3468	4	histopathologic	histopathologic	PROPN
fnp-3806	3468	5	correlates	correlate	VERB
fnp-3806	3468	6	of	of	ADP
fnp-3806	3468	7	white	white	ADJ
fnp-3806	3468	8	matter	matter	NOUN
fnp-3806	3468	9	changes	change	NOUN
fnp-3806	3468	10	on	on	ADP
fnp-3806	3468	11	mri	mri	NOUN
fnp-3806	3468	12	in	in	ADP
fnp-3806	3468	13	alzheimer	alzheimer	PROPN
fnp-3806	3468	14	's	's	PART
fnp-3806	3468	15	disease	disease	NOUN
fnp-3806	3468	16	and	and	CCONJ
fnp-3806	3468	17	normal	normal	ADJ
fnp-3806	3468	18	aging	aging	NOUN
fnp-3806	3468	19	.	.	PUNCT
fnp-3806	3469	1	neurology	neurology	NOUN
fnp-3806	3469	2	1995;45:883	1995;45:883	PROPN
fnp-3806	3469	3	-	-	PUNCT
fnp-3806	3469	4	888	888	NUM
fnp-3806	3469	5	.	.	PUNCT
fnp-3806	3470	1	https://doi.org/10.1212/wnl.45.5.883	https://doi.org/10.1212/wnl.45.5.883	NOUN
fnp-3806	3470	2	salat	salat	ADJ
fnp-3806	3470	3	dh	dh	NOUN
fnp-3806	3470	4	,	,	PUNCT
fnp-3806	3470	5	tuch	tuch	PROPN
fnp-3806	3470	6	ds	ds	PROPN
fnp-3806	3470	7	,	,	PUNCT
fnp-3806	3470	8	greve	greve	PROPN
fnp-3806	3470	9	dn	dn	PROPN
fnp-3806	3470	10	,	,	PUNCT
fnp-3806	3470	11	et	et	PROPN
fnp-3806	3470	12	al	al	PROPN
fnp-3806	3470	13	.	.	PUNCT
fnp-3806	3471	1	age	age	NOUN
fnp-3806	3471	2	-	-	PUNCT
fnp-3806	3471	3	related	relate	VERB
fnp-3806	3471	4	alterations	alteration	NOUN
fnp-3806	3471	5	in	in	ADP
fnp-3806	3471	6	white	white	ADJ
fnp-3806	3471	7	matter	matter	NOUN
fnp-3806	3471	8	microstructure	microstructure	NOUN
fnp-3806	3471	9	measured	measure	VERB
fnp-3806	3471	10	by	by	ADP
fnp-3806	3471	11	diffusion	diffusion	NOUN
fnp-3806	3471	12	tensor	tensor	NOUN
fnp-3806	3471	13	imaging	imaging	NOUN
fnp-3806	3471	14	.	.	PUNCT
fnp-3806	3472	1	neurobiol	neurobiol	PROPN
fnp-3806	3472	2	aging	age	VERB
fnp-3806	3472	3	2005	2005	NUM
fnp-3806	3472	4	;	;	PUNCT
fnp-3806	3472	5	26:1215	26:1215	NUM
fnp-3806	3472	6	-	-	SYM
fnp-3806	3472	7	1227	1227	NUM
fnp-3806	3472	8	.	.	PUNCT
fnp-3806	3473	1	https://doi.org/10.1016/j.neurobiolaging.12004.09.017	https://doi.org/10.1016/j.neurobiolaging.12004.09.017	AUX
fnp-3806	3473	2	holland	holland	PROPN
fnp-3806	3473	3	cm	cm	PROPN
fnp-3806	3473	4	,	,	PUNCT
fnp-3806	3473	5	smith	smith	PROPN
fnp-3806	3473	6	ee	ee	PROPN
fnp-3806	3473	7	,	,	PUNCT
fnp-3806	3473	8	csapo	csapo	PROPN
fnp-3806	3473	9	i	i	PRON
fnp-3806	3473	10	,	,	PUNCT
fnp-3806	3473	11	et	et	PROPN
fnp-3806	3473	12	al	al	PROPN
fnp-3806	3473	13	.	.	PUNCT
fnp-3806	3474	1	spatial	spatial	ADJ
fnp-3806	3474	2	distribution	distribution	NOUN
fnp-3806	3474	3	of	of	ADP
fnp-3806	3474	4	white	white	ADJ
fnp-3806	3474	5	-	-	PUNCT
fnp-3806	3474	6	matter	matter	NOUN
fnp-3806	3474	7	hyperintensities	hyperintensitie	NOUN
fnp-3806	3474	8	in	in	ADP
fnp-3806	3474	9	alzheimer	alzheimer	PROPN
fnp-3806	3474	10	disease	disease	PROPN
fnp-3806	3474	11	,	,	PUNCT
fnp-3806	3474	12	cerebral	cerebral	ADJ
fnp-3806	3474	13	amyloid	amyloid	NOUN
fnp-3806	3474	14	angiopathy	angiopathy	NOUN
fnp-3806	3474	15	,	,	PUNCT
fnp-3806	3474	16	and	and	CCONJ
fnp-3806	3474	17	healthy	healthy	ADJ
fnp-3806	3474	18	aging	aging	NOUN
fnp-3806	3474	19	.	.	PUNCT
fnp-3806	3475	1	stroke	stroke	NOUN
fnp-3806	3475	2	2008	2008	NUM
fnp-3806	3475	3	;	;	PUNCT
fnp-3806	3475	4	39	39	NUM
fnp-3806	3475	5	:	:	PUNCT
fnp-3806	3475	6	1127	1127	NUM
fnp-3806	3475	7	-	-	SYM
fnp-3806	3475	8	1133	1133	NUM
fnp-3806	3475	9	.	.	PUNCT
fnp-3806	3476	1	https://doi.org/10.1161/strokeaha.107.497438	https://doi.org/10.1161/strokeaha.107.497438	PROPN
fnp-3806	3476	2	liu	liu	PROPN
fnp-3806	3476	3	h	h	PROPN
fnp-3806	3476	4	,	,	PUNCT
fnp-3806	3476	5	yang	yang	PROPN
fnp-3806	3476	6	y	y	PROPN
fnp-3806	3476	7	,	,	PUNCT
fnp-3806	3476	8	xi	xi	PROPN
fnp-3806	3476	9	y	y	PROPN
fnp-3806	3476	10	,	,	PUNCT
fnp-3806	3476	11	et	et	PROPN
fnp-3806	3476	12	al	al	PROPN
fnp-3806	3476	13	.	.	PROPN
fnp-3806	3476	14	aging	aging	NOUN
fnp-3806	3476	15	of	of	ADP
fnp-3806	3476	16	cerebral	cerebral	ADJ
fnp-3806	3476	17	white	white	ADJ
fnp-3806	3476	18	matter	matter	NOUN
fnp-3806	3476	19	.	.	PUNCT
fnp-3806	3477	1	ageing	age	VERB
fnp-3806	3477	2	res	re	NOUN
fnp-3806	3477	3	rev	rev	PROPN
fnp-3806	3477	4	2017;34:64	2017;34:64	PROPN
fnp-3806	3477	5	-	-	SYM
fnp-3806	3477	6	76	76	NUM
fnp-3806	3477	7	.	.	PUNCT
fnp-3806	3478	1	https://doi.org/10.1016/j.arr.2016.11.006	https://doi.org/10.1016/j.arr.2016.11.006	PROPN
fnp-3806	3478	2	marner	marner	PROPN
fnp-3806	3478	3	l	l	PROPN
fnp-3806	3478	4	,	,	PUNCT
fnp-3806	3478	5	nyengaard	nyengaard	PROPN
fnp-3806	3478	6	jr	jr	PROPN
fnp-3806	3478	7	,	,	PUNCT
fnp-3806	3478	8	tang	tang	PROPN
fnp-3806	3478	9	y	y	PROPN
fnp-3806	3478	10	,	,	PUNCT
fnp-3806	3478	11	et	et	PROPN
fnp-3806	3478	12	al	al	PROPN
fnp-3806	3478	13	.	.	PROPN
fnp-3806	3478	14	marked	mark	VERB
fnp-3806	3478	15	loss	loss	NOUN
fnp-3806	3478	16	of	of	ADP
fnp-3806	3478	17	myelinated	myelinated	ADJ
fnp-3806	3478	18	nerve	nerve	NOUN
fnp-3806	3478	19	fibers	fiber	NOUN
fnp-3806	3478	20	in	in	ADP
fnp-3806	3478	21	the	the	DET
fnp-3806	3478	22	human	human	ADJ
fnp-3806	3478	23	brain	brain	NOUN
fnp-3806	3478	24	with	with	ADP
fnp-3806	3478	25	age	age	NOUN
fnp-3806	3478	26	.	.	PUNCT
fnp-3806	3479	1	https://doi.org/10.1016/j.arr.2016.11.006	https://doi.org/10.1016/j.arr.2016.11.006	PROPN
fnp-3806	3479	2	erten	erten	PROPN
fnp-3806	3479	3	-	-	PUNCT
fnp-3806	3479	4	lyons	lyons	PROPN
fnp-3806	3479	5	d	d	NOUN
fnp-3806	3479	6	,	,	PUNCT
fnp-3806	3479	7	woltjer	woltjer	ADJ
fnp-3806	3479	8	r	r	NOUN
fnp-3806	3479	9	,	,	PUNCT
fnp-3806	3479	10	kaye	kaye	PROPN
fnp-3806	3479	11	j	j	PROPN
fnp-3806	3479	12	,	,	PUNCT
fnp-3806	3479	13	et	et	PROPN
fnp-3806	3479	14	al	al	PROPN
fnp-3806	3479	15	.	.	PROPN
fnp-3806	3479	16	neuropathologic	neuropathologic	ADJ
fnp-3806	3479	17	basis	basis	NOUN
fnp-3806	3479	18	of	of	ADP
fnp-3806	3479	19	white	white	ADJ
fnp-3806	3479	20	matter	matter	NOUN
fnp-3806	3479	21	hyperintensity	hyperintensity	NOUN
fnp-3806	3479	22	accumulation	accumulation	NOUN
fnp-3806	3479	23	with	with	ADP
fnp-3806	3479	24	advanced	advanced	ADJ
fnp-3806	3479	25	age	age	NOUN
fnp-3806	3479	26	.	.	PUNCT
fnp-3806	3480	1	neurology	neurology	NOUN
fnp-3806	3480	2	2013	2013	NUM
fnp-3806	3480	3	;	;	PUNCT
fnp-3806	3480	4	81	81	NUM
fnp-3806	3480	5	:	:	SYM
fnp-3806	3480	6	977	977	NUM
fnp-3806	3480	7	-	-	SYM
fnp-3806	3480	8	983	983	NUM
fnp-3806	3480	9	.	.	PUNCT
fnp-3806	3481	1	https://doi.org/10.1016/j.arr.2016.11.006	https://doi.org/10.1016/j.arr.2016.11.006	PROPN
fnp-3806	3481	2	kohama	kohama	PROPN
fnp-3806	3481	3	sg	sg	PROPN
fnp-3806	3481	4	,	,	PUNCT
fnp-3806	3481	5	rosene	rosene	PROPN
fnp-3806	3481	6	dl	dl	PROPN
fnp-3806	3481	7	,	,	PUNCT
fnp-3806	3481	8	sherman	sherman	PROPN
fnp-3806	3481	9	ls	ls	PROPN
fnp-3806	3481	10	.	.	PUNCT
fnp-3806	3481	11	age	age	NOUN
fnp-3806	3481	12	-	-	PUNCT
fnp-3806	3481	13	related	relate	VERB
fnp-3806	3481	14	changes	change	NOUN
fnp-3806	3481	15	in	in	ADP
fnp-3806	3481	16	human	human	ADJ
fnp-3806	3481	17	and	and	CCONJ
fnp-3806	3481	18	non	non	ADJ
fnp-3806	3481	19	-	-	ADJ
fnp-3806	3481	20	human	human	ADJ
fnp-3806	3481	21	primate	primate	NOUN
fnp-3806	3481	22	white	white	ADJ
fnp-3806	3481	23	matter	matter	NOUN
fnp-3806	3481	24	:	:	PUNCT
fnp-3806	3481	25	from	from	ADP
fnp-3806	3481	26	myelination	myelination	ADJ
fnp-3806	3481	27	disturbances	disturbance	NOUN
fnp-3806	3481	28	to	to	ADP
fnp-3806	3481	29	cognitive	cognitive	ADJ
fnp-3806	3481	30	decline	decline	NOUN
fnp-3806	3481	31	.	.	PUNCT
fnp-3806	3482	1	age	age	NOUN
fnp-3806	3482	2	2012	2012	NUM
fnp-3806	3482	3	;	;	PUNCT
fnp-3806	3482	4	34	34	NUM
fnp-3806	3482	5	:	:	SYM
fnp-3806	3482	6	1093	1093	NUM
fnp-3806	3482	7	-	-	SYM
fnp-3806	3482	8	1110	1110	NUM
fnp-3806	3482	9	.	.	PUNCT
fnp-3806	3483	1	https://doi.org/10.1007/s11357-011-9357-7	https://doi.org/10.1007/s11357-011-9357-7	PROPN
fnp-3806	3484	1	bartzokis	bartzokis	PROPN
fnp-3806	3484	2	g	g	PROPN
fnp-3806	3484	3	,	,	PUNCT
fnp-3806	3484	4	cummings	cummings	PROPN
fnp-3806	3484	5	jl	jl	PROPN
fnp-3806	3484	6	,	,	PUNCT
fnp-3806	3484	7	sultzer	sultzer	NOUN
fnp-3806	3484	8	d	d	PROPN
fnp-3806	3484	9	,	,	PUNCT
fnp-3806	3484	10	et	et	PROPN
fnp-3806	3484	11	al	al	PROPN
fnp-3806	3484	12	.	.	PROPN
fnp-3806	3485	1	white	white	PROPN
fnp-3806	3485	2	matter	matter	PROPN
fnp-3806	3485	3	structural	structural	ADJ
fnp-3806	3485	4	integrity	integrity	NOUN
fnp-3806	3485	5	in	in	ADP
fnp-3806	3485	6	healthy	healthy	ADJ
fnp-3806	3485	7	aging	age	VERB
fnp-3806	3485	8	adults	adult	NOUN
fnp-3806	3485	9	and	and	CCONJ
fnp-3806	3485	10	patients	patient	NOUN
fnp-3806	3485	11	with	with	ADP
fnp-3806	3485	12	alzheimer	alzheimer	PROPN
fnp-3806	3485	13	disease	disease	PROPN
fnp-3806	3485	14	:	:	PUNCT
fnp-3806	3485	15	a	a	DET
fnp-3806	3485	16	magnetic	magnetic	ADJ
fnp-3806	3485	17	resonance	resonance	NOUN
fnp-3806	3485	18	imaging	imaging	NOUN
fnp-3806	3485	19	study	study	NOUN
fnp-3806	3485	20	.	.	PUNCT
fnp-3806	3486	1	arch	arch	ADJ
fnp-3806	3486	2	neurol	neurol	NOUN
fnp-3806	3486	3	2003	2003	NUM
fnp-3806	3486	4	;	;	PUNCT
fnp-3806	3486	5	60	60	NUM
fnp-3806	3486	6	:	:	SYM
fnp-3806	3486	7	393	393	NUM
fnp-3806	3486	8	-	-	SYM
fnp-3806	3486	9	398	398	NUM
fnp-3806	3486	10	.	.	PUNCT
fnp-3806	3487	1	https://doi.org/10.1001/archneur.60.3.393	https://doi.org/10.1001/archneur.60.3.393	PRON
fnp-3806	3487	2	wang	wang	PROPN
fnp-3806	3487	3	l	l	PROPN
fnp-3806	3487	4	,	,	PUNCT
fnp-3806	3487	5	goldstein	goldstein	PROPN
fnp-3806	3487	6	fc	fc	PROPN
fnp-3806	3487	7	,	,	PUNCT
fnp-3806	3487	8	levey	levey	PROPN
fnp-3806	3487	9	ai	ai	PROPN
fnp-3806	3487	10	,	,	PUNCT
fnp-3806	3487	11	et	et	PROPN
fnp-3806	3487	12	al	al	PROPN
fnp-3806	3487	13	.	.	PROPN
fnp-3806	3487	14	white	white	PROPN
fnp-3806	3487	15	matter	matter	PROPN
fnp-3806	3487	16	hyperintensities	hyperintensitie	NOUN
fnp-3806	3487	17	and	and	CCONJ
fnp-3806	3487	18	changes	change	NOUN
fnp-3806	3487	19	in	in	ADP
fnp-3806	3487	20	white	white	ADJ
fnp-3806	3487	21	matter	matter	NOUN
fnp-3806	3487	22	integrity	integrity	NOUN
fnp-3806	3487	23	in	in	ADP
fnp-3806	3487	24	patients	patient	NOUN
fnp-3806	3487	25	with	with	ADP
fnp-3806	3487	26	alzheimer	alzheimer	PROPN
fnp-3806	3487	27	’s	’s	PART
fnp-3806	3487	28	disease	disease	NOUN
fnp-3806	3487	29	.	.	PUNCT
fnp-3806	3488	1	neuroradiology	neuroradiology	NOUN
fnp-3806	3488	2	2011;53:373	2011;53:373	PROPN
fnp-3806	3488	3	-	-	SYM
fnp-3806	3488	4	381	381	NUM
fnp-3806	3488	5	.	.	PUNCT
fnp-3806	3489	1	https://doi.org/10.1007/s00234-010-0806-2	https://doi.org/10.1007/s00234-010-0806-2	NUM
fnp-3806	3489	2	radanovic	radanovic	PROPN
fnp-3806	3489	3	m	m	PROPN
fnp-3806	3489	4	,	,	PUNCT
fnp-3806	3489	5	pereira	pereira	PROPN
fnp-3806	3489	6	fr	fr	PROPN
fnp-3806	3489	7	,	,	PUNCT
fnp-3806	3489	8	stella	stella	PROPN
fnp-3806	3489	9	f	f	PROPN
fnp-3806	3489	10	,	,	PUNCT
fnp-3806	3489	11	et	et	PROPN
fnp-3806	3489	12	al	al	PROPN
fnp-3806	3489	13	.	.	PROPN
fnp-3806	3489	14	white	white	PROPN
fnp-3806	3489	15	matter	matter	PROPN
fnp-3806	3489	16	abnormalities	abnormality	NOUN
fnp-3806	3489	17	associated	associate	VERB
fnp-3806	3489	18	with	with	ADP
fnp-3806	3489	19	alzheimer	alzheimer	PROPN
fnp-3806	3489	20	's	's	PART
fnp-3806	3489	21	disease	disease	NOUN
fnp-3806	3489	22	and	and	CCONJ
fnp-3806	3489	23	mild	mild	ADJ
fnp-3806	3489	24	cognitive	cognitive	ADJ
fnp-3806	3489	25	impairment	impairment	NOUN
fnp-3806	3489	26	:	:	PUNCT
fnp-3806	3489	27	a	a	DET
fnp-3806	3489	28	critical	critical	ADJ
fnp-3806	3489	29	review	review	NOUN
fnp-3806	3489	30	of	of	ADP
fnp-3806	3489	31	mri	mri	NOUN
fnp-3806	3489	32	studies	study	NOUN
fnp-3806	3489	33	.	.	PUNCT
fnp-3806	3490	1	expert	expert	NOUN
fnp-3806	3490	2	rev	rev	VERB
fnp-3806	3490	3	neurother	neurother	ADP
fnp-3806	3490	4	2013	2013	NUM
fnp-3806	3490	5	;	;	PUNCT
fnp-3806	3490	6	13:483	13:483	NUM
fnp-3806	3490	7	-	-	SYM
fnp-3806	3490	8	493	493	NUM
fnp-3806	3490	9	.	.	PUNCT
fnp-3806	3491	1	https://doi.org/10.1586/ern.13.45	https://doi.org/10.1586/ern.13.45	PROPN
fnp-3806	3491	2	selnes	selne	NOUN
fnp-3806	3491	3	p	p	X
fnp-3806	3491	4	,	,	PUNCT
fnp-3806	3491	5	fjell	fjell	PROPN
fnp-3806	3491	6	am	am	PROPN
fnp-3806	3491	7	,	,	PUNCT
fnp-3806	3491	8	gjerstad	gjerstad	PROPN
fnp-3806	3491	9	l	l	PROPN
fnp-3806	3491	10	,	,	PUNCT
fnp-3806	3491	11	et	et	PROPN
fnp-3806	3491	12	al	al	PROPN
fnp-3806	3491	13	.	.	PROPN
fnp-3806	3491	14	white	white	PROPN
fnp-3806	3491	15	matter	matter	PROPN
fnp-3806	3491	16	imaging	imaging	NOUN
fnp-3806	3491	17	changes	change	NOUN
fnp-3806	3491	18	in	in	ADP
fnp-3806	3491	19	subjective	subjective	ADJ
fnp-3806	3491	20	and	and	CCONJ
fnp-3806	3491	21	mild	mild	ADJ
fnp-3806	3491	22	cognitive	cognitive	ADJ
fnp-3806	3491	23	impairment	impairment	NOUN
fnp-3806	3491	24	.	.	PUNCT
fnp-3806	3492	1	alzheimers	alzheimers	PROPN
fnp-3806	3492	2	dement	dement	PROPN
fnp-3806	3492	3	2012;8	2012;8	NUM
fnp-3806	3492	4	:	:	PUNCT
fnp-3806	3492	5	s112	s112	PROPN
fnp-3806	3492	6	-	-	PUNCT
fnp-3806	3492	7	s121	s121	PROPN
fnp-3806	3492	8	.	.	PUNCT
fnp-3806	3493	1	https://doi.org/10.1016/j.jalz.2011.07.001	https://doi.org/10.1016/j.jalz.2011.07.001	VERB
fnp-3806	3493	2	molinuevo	molinuevo	PROPN
fnp-3806	3493	3	jl	jl	PROPN
fnp-3806	3493	4	,	,	PUNCT
fnp-3806	3493	5	ripolles	ripolle	NOUN
fnp-3806	3493	6	p	p	PROPN
fnp-3806	3493	7	,	,	PUNCT
fnp-3806	3493	8	simo	simo	PROPN
fnp-3806	3493	9	m	m	PROPN
fnp-3806	3493	10	,	,	PUNCT
fnp-3806	3493	11	et	et	PROPN
fnp-3806	3493	12	al	al	PROPN
fnp-3806	3493	13	.	.	PROPN
fnp-3806	3493	14	white	white	PROPN
fnp-3806	3493	15	matter	matter	NOUN
fnp-3806	3493	16	changes	change	NOUN
fnp-3806	3493	17	in	in	ADP
fnp-3806	3493	18	preclinical	preclinical	ADJ
fnp-3806	3493	19	alzheimer	alzheimer	NOUN
fnp-3806	3493	20	's	's	PART
fnp-3806	3493	21	disease	disease	NOUN
fnp-3806	3493	22	:	:	PUNCT
fnp-3806	3493	23	a	a	DET
fnp-3806	3493	24	magnetic	magnetic	ADJ
fnp-3806	3493	25	resonance	resonance	NOUN
fnp-3806	3493	26	imaging	imaging	NOUN
fnp-3806	3493	27	diffusion	diffusion	NOUN
fnp-3806	3493	28	tensor	tensor	NOUN
fnp-3806	3493	29	imaging	imaging	NOUN
fnp-3806	3493	30	study	study	NOUN
fnp-3806	3493	31	on	on	ADP
fnp-3806	3493	32	cognitively	cognitively	ADV
fnp-3806	3493	33	normal	normal	ADJ
fnp-3806	3493	34	older	old	ADJ
fnp-3806	3493	35	people	people	NOUN
fnp-3806	3493	36	with	with	ADP
fnp-3806	3493	37	positive	positive	ADJ
fnp-3806	3493	38	amyloid	amyloid	NOUN
fnp-3806	3493	39	beta	beta	NOUN
fnp-3806	3493	40	protein	protein	NOUN
fnp-3806	3493	41	42	42	NUM
fnp-3806	3493	42	levels	level	NOUN
fnp-3806	3493	43	.	.	PUNCT
fnp-3806	3494	1	neurobiol	neurobiol	ADJ
fnp-3806	3494	2	aging	age	VERB
fnp-3806	3494	3	2014	2014	NUM
fnp-3806	3494	4	;	;	PUNCT
fnp-3806	3494	5	35	35	NUM
fnp-3806	3494	6	:	:	SYM
fnp-3806	3494	7	2671	2671	NUM
fnp-3806	3494	8	-	-	SYM
fnp-3806	3494	9	2680	2680	NUM
fnp-3806	3494	10	.	.	PUNCT
fnp-3806	3495	1	https://doi.org/10.1016/j.neurobiolaging.2014.05.027	https://doi.org/10.1016/j.neurobiolaging.2014.05.027	DET
fnp-3806	3495	2	hoy	hoy	PROPN
fnp-3806	3495	3	ar	ar	PROPN
fnp-3806	3495	4	,	,	PUNCT
fnp-3806	3495	5	ly	ly	ADP
fnp-3806	3495	6	m	m	PROPN
fnp-3806	3495	7	,	,	PUNCT
fnp-3806	3495	8	carlsson	carlsson	PROPN
fnp-3806	3495	9	cm	cm	PROPN
fnp-3806	3495	10	,	,	PUNCT
fnp-3806	3495	11	okonkwo	okonkwo	PROPN
fnp-3806	3495	12	oc	oc	PROPN
fnp-3806	3495	13	,	,	PUNCT
fnp-3806	3495	14	et	et	PROPN
fnp-3806	3495	15	al	al	PROPN
fnp-3806	3495	16	.	.	PROPN
fnp-3806	3495	17	microstructural	microstructural	PROPN
fnp-3806	3495	18	white	white	PROPN
fnp-3806	3495	19	matter	matter	NOUN
fnp-3806	3495	20	alterations	alteration	NOUN
fnp-3806	3495	21	in	in	ADP
fnp-3806	3495	22	preclinical	preclinical	ADJ
fnp-3806	3495	23	alzheimer	alzheimer	NOUN
fnp-3806	3495	24	's	's	PART
fnp-3806	3495	25	disease	disease	NOUN
fnp-3806	3495	26	detected	detect	VERB
fnp-3806	3495	27	using	use	VERB
fnp-3806	3495	28	free	free	ADJ
fnp-3806	3495	29	water	water	NOUN
fnp-3806	3495	30	elimination	elimination	NOUN
fnp-3806	3495	31	diffusion	diffusion	NOUN
fnp-3806	3495	32	tensor	tensor	NOUN
fnp-3806	3495	33	imaging	imaging	NOUN
fnp-3806	3495	34	.	.	PUNCT
fnp-3806	3496	1	plos	plos	PROPN
fnp-3806	3496	2	one	one	NUM
fnp-3806	3496	3	2017	2017	NUM
fnp-3806	3496	4	;	;	PUNCT
fnp-3806	3496	5	12	12	NUM
fnp-3806	3496	6	:	:	PUNCT
fnp-3806	3496	7	e0173982	e0173982	PROPN
fnp-3806	3496	8	.	.	PUNCT
fnp-3806	3496	9	https://doi.org/10.1371/journal.pone.0173982	https://doi.org/10.1371/journal.pone.0173982	PROPN
fnp-3806	3496	10	bouhrara	bouhrara	PROPN
fnp-3806	3496	11	m	m	PROPN
fnp-3806	3496	12	,	,	PUNCT
fnp-3806	3496	13	reiter	reiter	PROPN
fnp-3806	3496	14	da	da	PROPN
fnp-3806	3496	15	,	,	PUNCT
fnp-3806	3496	16	bergeron	bergeron	PROPN
fnp-3806	3496	17	cm	cm	PROPN
fnp-3806	3496	18	,	,	PUNCT
fnp-3806	3496	19	et	et	PROPN
fnp-3806	3496	20	al	al	PROPN
fnp-3806	3496	21	.	.	PROPN
fnp-3806	3497	1	evidence	evidence	NOUN
fnp-3806	3497	2	of	of	ADP
fnp-3806	3497	3	demyelination	demyelination	NOUN
fnp-3806	3497	4	in	in	ADP
fnp-3806	3497	5	mild	mild	ADJ
fnp-3806	3497	6	cognitive	cognitive	ADJ
fnp-3806	3497	7	impairment	impairment	NOUN
fnp-3806	3497	8	and	and	CCONJ
fnp-3806	3497	9	dementia	dementia	NOUN
fnp-3806	3497	10	using	use	VERB
fnp-3806	3497	11	a	a	DET
fnp-3806	3497	12	direct	direct	ADJ
fnp-3806	3497	13	and	and	CCONJ
fnp-3806	3497	14	specific	specific	ADJ
fnp-3806	3497	15	magnetic	magnetic	ADJ
fnp-3806	3497	16	resonance	resonance	NOUN
fnp-3806	3497	17	imaging	imaging	NOUN
fnp-3806	3497	18	measure	measure	NOUN
fnp-3806	3497	19	of	of	ADP
fnp-3806	3497	20	myelin	myelin	NOUN
fnp-3806	3497	21	content	content	NOUN
fnp-3806	3497	22	.	.	PUNCT
fnp-3806	3498	1	alzheimers	alzheimers	PROPN
fnp-3806	3498	2	dement	dement	PROPN
fnp-3806	3498	3	2018	2018	NUM
fnp-3806	3498	4	;	;	PUNCT
fnp-3806	3498	5	14	14	NUM
fnp-3806	3498	6	:	:	SYM
fnp-3806	3498	7	998	998	NUM
fnp-3806	3498	8	-	-	SYM
fnp-3806	3498	9	1004	1004	NUM
fnp-3806	3498	10	.	.	PUNCT
fnp-3806	3499	1	https://doi.org/10.1016/j.jalz.2018.03.007	https://doi.org/10.1016/j.jalz.2018.03.007	PROPN
fnp-3806	3499	2	zhang	zhang	PROPN
fnp-3806	3499	3	x	x	PROPN
fnp-3806	3499	4	,	,	PUNCT
fnp-3806	3499	5	sun	sun	PROPN
fnp-3806	3499	6	y	y	PROPN
fnp-3806	3499	7	,	,	PUNCT
fnp-3806	3499	8	li	li	PROPN
fnp-3806	3499	9	w	w	PROPN
fnp-3806	3499	10	,	,	PUNCT
fnp-3806	3499	11	et	et	PROPN
fnp-3806	3499	12	al	al	PROPN
fnp-3806	3499	13	.	.	PUNCT
fnp-3806	3499	14	characterization	characterization	NOUN
fnp-3806	3499	15	of	of	ADP
fnp-3806	3499	16	white	white	ADJ
fnp-3806	3499	17	matter	matter	NOUN
fnp-3806	3499	18	changes	change	NOUN
fnp-3806	3499	19	along	along	ADP
fnp-3806	3499	20	fibers	fiber	NOUN
fnp-3806	3499	21	by	by	ADP
fnp-3806	3499	22	automated	automate	VERB
fnp-3806	3499	23	fiber	fiber	NOUN
fnp-3806	3499	24	quantification	quantification	NOUN
fnp-3806	3499	25	in	in	ADP
fnp-3806	3499	26	the	the	DET
fnp-3806	3499	27	early	early	ADJ
fnp-3806	3499	28	stages	stage	NOUN
fnp-3806	3499	29	of	of	ADP
fnp-3806	3499	30	alzheimer	alzheimer	PROPN
fnp-3806	3499	31	's	's	PART
fnp-3806	3499	32	disease	disease	NOUN
fnp-3806	3499	33	neuroimage	neuroimage	NOUN
fnp-3806	3499	34	:	:	PUNCT
fnp-3806	3499	35	clinical	clinical	ADJ
fnp-3806	3499	36	2019	2019	NUM
fnp-3806	3499	37	;	;	PUNCT
fnp-3806	3499	38	22	22	NUM
fnp-3806	3499	39	:	:	SYM
fnp-3806	3499	40	101723	101723	NUM
fnp-3806	3499	41	.	.	PUNCT
fnp-3806	3500	1	https://doi.org/10.1016/j.nicl.2019.101723	https://doi.org/10.1016/j.nicl.2019.101723	ADJ
fnp-3806	3500	2	gouw	gouw	NOUN
fnp-3806	3500	3	aa	aa	NOUN
fnp-3806	3500	4	,	,	PUNCT
fnp-3806	3500	5	seewann	seewann	PROPN
fnp-3806	3500	6	a	a	PROPN
fnp-3806	3500	7	,	,	PUNCT
fnp-3806	3500	8	vrenken	vrenken	ADJ
fnp-3806	3500	9	h	h	NOUN
fnp-3806	3500	10	,	,	PUNCT
fnp-3806	3500	11	et	et	PROPN
fnp-3806	3500	12	al	al	PROPN
fnp-3806	3500	13	.	.	PUNCT
fnp-3806	3500	14	heterogeneity	heterogeneity	PROPN
fnp-3806	3500	15	of	of	ADP
fnp-3806	3500	16	white	white	ADJ
fnp-3806	3500	17	matter	matter	PROPN
fnp-3806	3500	18	hyperintensities	hyperintensitie	NOUN
fnp-3806	3500	19	in	in	ADP
fnp-3806	3500	20	alzheimer	alzheimer	PROPN
fnp-3806	3500	21	's	's	PART
fnp-3806	3500	22	disease	disease	NOUN
fnp-3806	3500	23	:	:	PUNCT
fnp-3806	3500	24	post	post	ADJ
fnp-3806	3500	25	-	-	ADJ
fnp-3806	3500	26	mortem	mortem	ADJ
fnp-3806	3500	27	quantitative	quantitative	ADJ
fnp-3806	3500	28	mri	mri	NOUN
fnp-3806	3500	29	and	and	CCONJ
fnp-3806	3500	30	neuropathology	neuropathology	NOUN
fnp-3806	3500	31	.	.	PUNCT
fnp-3806	3501	1	brain	brain	PROPN
fnp-3806	3501	2	2008	2008	NUM
fnp-3806	3501	3	;	;	PUNCT
fnp-3806	3501	4	131	131	NUM
fnp-3806	3501	5	:	:	SYM
fnp-3806	3501	6	3286	3286	NUM
fnp-3806	3501	7	-	-	SYM
fnp-3806	3501	8	3298	3298	NUM
fnp-3806	3501	9	.	.	PUNCT
fnp-3806	3502	1	https://doi.org/10.1093/brain/awn265	https://doi.org/10.1093/brain/awn265	NOUN
fnp-3806	3502	2	ihara	ihara	PROPN
fnp-3806	3502	3	m	m	PROPN
fnp-3806	3502	4	,	,	PUNCT
fnp-3806	3502	5	polvikoski	polvikoski	PROPN
fnp-3806	3502	6	tm	tm	PROPN
fnp-3806	3502	7	,	,	PUNCT
fnp-3806	3502	8	hall	hall	NOUN
fnp-3806	3502	9	r	r	NOUN
fnp-3806	3502	10	,	,	PUNCT
fnp-3806	3502	11	et	et	PROPN
fnp-3806	3502	12	al	al	PROPN
fnp-3806	3502	13	.	.	PUNCT
fnp-3806	3503	1	quantification	quantification	NOUN
fnp-3806	3503	2	of	of	ADP
fnp-3806	3503	3	myelin	myelin	ADJ
fnp-3806	3503	4	loss	loss	NOUN
fnp-3806	3503	5	in	in	ADP
fnp-3806	3503	6	frontal	frontal	ADJ
fnp-3806	3503	7	lobe	lobe	ADJ
fnp-3806	3503	8	white	white	ADJ
fnp-3806	3503	9	matter	matter	NOUN
fnp-3806	3503	10	in	in	ADP
fnp-3806	3503	11	vascular	vascular	ADJ
fnp-3806	3503	12	dementia	dementia	NOUN
fnp-3806	3503	13	,	,	PUNCT
fnp-3806	3503	14	alzheimer	alzheimer	PROPN
fnp-3806	3503	15	’s	’s	PART
fnp-3806	3503	16	disease	disease	NOUN
fnp-3806	3503	17	,	,	PUNCT
fnp-3806	3503	18	and	and	CCONJ
fnp-3806	3503	19	dementia	dementia	NOUN
fnp-3806	3503	20	with	with	ADP
fnp-3806	3503	21	lewy	lewy	PROPN
fnp-3806	3503	22	bodies	body	NOUN
fnp-3806	3503	23	.	.	PUNCT
fnp-3806	3504	1	acta	acta	PROPN
fnp-3806	3504	2	neuropathol	neuropathol	PROPN
fnp-3806	3504	3	2010	2010	NUM
fnp-3806	3504	4	;	;	PUNCT
fnp-3806	3504	5	119	119	NUM
fnp-3806	3504	6	:	:	SYM
fnp-3806	3504	7	579	579	NUM
fnp-3806	3504	8	-	-	SYM
fnp-3806	3504	9	589	589	NUM
fnp-3806	3504	10	.	.	PUNCT
fnp-3806	3505	1	https://doi.org/10.1007/s00401-009-0	https://doi.org/10.1007/s00401-009-0	PROPN
fnp-3806	3505	2	35	35	NUM
fnp-3806	3505	3	-	-	SYM
fnp-3806	3505	4	8	8	NUM
fnp-3806	3505	5	.	.	PUNCT
fnp-3806	3505	6	rose	rise	VERB
fnp-3806	3505	7	se	se	ADV
fnp-3806	3505	8	,	,	PUNCT
fnp-3806	3505	9	chen	chen	PROPN
fnp-3806	3505	10	f	f	PROPN
fnp-3806	3505	11	,	,	PUNCT
fnp-3806	3505	12	chalk	chalk	NOUN
fnp-3806	3505	13	jb	jb	PROPN
fnp-3806	3505	14	,	,	PUNCT
fnp-3806	3505	15	et	et	PROPN
fnp-3806	3505	16	al	al	PROPN
fnp-3806	3505	17	.	.	PUNCT
fnp-3806	3506	1	loss	loss	NOUN
fnp-3806	3506	2	of	of	ADP
fnp-3806	3506	3	connectivity	connectivity	NOUN
fnp-3806	3506	4	in	in	ADP
fnp-3806	3506	5	alzheimer	alzheimer	PROPN
fnp-3806	3506	6	's	's	PART
fnp-3806	3506	7	disease	disease	NOUN
fnp-3806	3506	8	:	:	PUNCT
fnp-3806	3506	9	an	an	DET
fnp-3806	3506	10	evaluation	evaluation	NOUN
fnp-3806	3506	11	of	of	ADP
fnp-3806	3506	12	white	white	ADJ
fnp-3806	3506	13	matter	matter	NOUN
fnp-3806	3506	14	tract	tract	NOUN
fnp-3806	3506	15	integrity	integrity	NOUN
fnp-3806	3506	16	with	with	ADP
fnp-3806	3506	17	colour	colour	NOUN
fnp-3806	3506	18	coded	code	VERB
fnp-3806	3506	19	mr	mr	PROPN
fnp-3806	3506	20	diffusion	diffusion	NOUN
fnp-3806	3506	21	tensor	tensor	NOUN
fnp-3806	3506	22	imaging	imaging	NOUN
fnp-3806	3506	23	.	.	PUNCT
fnp-3806	3507	1	j	j	PROPN
fnp-3806	3507	2	neurol	neurol	PROPN
fnp-3806	3507	3	neurosurg	neurosurg	PROPN
fnp-3806	3507	4	psychiatry	psychiatry	PROPN
fnp-3806	3507	5	2000;69:528	2000;69:528	PROPN
fnp-3806	3507	6	-	-	PUNCT
fnp-3806	3507	7	530	530	NUM
fnp-3806	3507	8	.	.	PUNCT
fnp-3806	3508	1	https://doi.org/10.1136/jnnp.69.4.528	https://doi.org/10.1136/jnnp.69.4.528	PROPN
fnp-3806	3508	2	bennett	bennett	PROPN
fnp-3806	3508	3	ij	ij	PROPN
fnp-3806	3508	4	,	,	PUNCT
fnp-3806	3508	5	madden	madden	PROPN
fnp-3806	3509	1	dj	dj	PROPN
fnp-3806	3509	2	.	.	PUNCT
fnp-3806	3510	1	disconnected	disconnected	ADJ
fnp-3806	3510	2	aging	aging	NOUN
fnp-3806	3510	3	:	:	PUNCT
fnp-3806	3510	4	cerebral	cerebral	ADJ
fnp-3806	3510	5	white	white	ADJ
fnp-3806	3510	6	matter	matter	NOUN
fnp-3806	3510	7	integrity	integrity	NOUN
fnp-3806	3510	8	and	and	CCONJ
fnp-3806	3510	9	age	age	NOUN
fnp-3806	3510	10	-	-	PUNCT
fnp-3806	3510	11	related	relate	VERB
fnp-3806	3510	12	differences	difference	NOUN
fnp-3806	3510	13	in	in	ADP
fnp-3806	3510	14	cognition	cognition	NOUN
fnp-3806	3510	15	.	.	PUNCT
fnp-3806	3511	1	neuroscience	neuroscience	NOUN
fnp-3806	3511	2	2014	2014	NUM
fnp-3806	3511	3	;	;	PUNCT
fnp-3806	3511	4	276	276	NUM
fnp-3806	3511	5	:	:	PUNCT
fnp-3806	3511	6	187	187	NUM
fnp-3806	3511	7	-	-	SYM
fnp-3806	3511	8	205	205	NUM
fnp-3806	3511	9	.	.	PUNCT
fnp-3806	3512	1	https://doi.org/10.1016/j.neuroscience.2013.11.026	https://doi.org/10.1016/j.neuroscience.2013.11.026	PROPN
fnp-3806	3512	2	desai	desai	PROPN
fnp-3806	3512	3	mk	mk	PROPN
fnp-3806	3512	4	,	,	PUNCT
fnp-3806	3512	5	sudol	sudol	VERB
fnp-3806	3512	6	kl	kl	PROPN
fnp-3806	3512	7	,	,	PUNCT
fnp-3806	3512	8	janelsins	janelsins	PROPN
fnp-3806	3512	9	mc	mc	PROPN
fnp-3806	3512	10	,	,	PUNCT
fnp-3806	3512	11	et	et	PROPN
fnp-3806	3512	12	al	al	PROPN
fnp-3806	3512	13	.	.	PUNCT
fnp-3806	3513	1	triple	triple	ADJ
fnp-3806	3513	2	-	-	PUNCT
fnp-3806	3513	3	transgenic	transgenic	ADJ
fnp-3806	3513	4	alzheimer	alzheimer	NOUN
fnp-3806	3513	5	’s	’s	PART
fnp-3806	3513	6	disease	disease	NOUN
fnp-3806	3513	7	mice	mice	NOUN
fnp-3806	3513	8	exhibit	exhibit	VERB
fnp-3806	3513	9	region	region	NOUN
fnp-3806	3513	10	-	-	PUNCT
fnp-3806	3513	11	specific	specific	ADJ
fnp-3806	3513	12	abnormalities	abnormality	NOUN
fnp-3806	3513	13	in	in	ADP
fnp-3806	3513	14	brain	brain	NOUN
fnp-3806	3513	15	myelination	myelination	NOUN
fnp-3806	3513	16	patterns	pattern	NOUN
fnp-3806	3513	17	prior	prior	ADV
fnp-3806	3513	18	to	to	ADP
fnp-3806	3513	19	appearance	appearance	NOUN
fnp-3806	3513	20	of	of	ADP
fnp-3806	3513	21	amyloid	amyloid	NOUN
fnp-3806	3513	22	and	and	CCONJ
fnp-3806	3513	23	tau	tau	PROPN
fnp-3806	3513	24	pathology	pathology	PROPN
fnp-3806	3513	25	.	.	PUNCT
fnp-3806	3514	1	glia	glia	PROPN
fnp-3806	3514	2	2009	2009	NUM
fnp-3806	3514	3	;	;	PUNCT
fnp-3806	3514	4	57	57	NUM
fnp-3806	3514	5	:	:	SYM
fnp-3806	3514	6	54	54	NUM
fnp-3806	3514	7	-	-	SYM
fnp-3806	3514	8	65	65	NUM
fnp-3806	3514	9	.	.	PUNCT
fnp-3806	3515	1	https://doi.org/10.1002/glia.20734	https://doi.org/10.1002/glia.20734	PROPN
fnp-3806	3515	2	kamphuis	kamphuis	PROPN
fnp-3806	3515	3	w	w	PROPN
fnp-3806	3515	4	,	,	PUNCT
fnp-3806	3515	5	orre	orre	PROPN
fnp-3806	3515	6	m	m	PROPN
fnp-3806	3515	7	,	,	PUNCT
fnp-3806	3515	8	kooijman	kooijman	PROPN
fnp-3806	3515	9	l	l	PROPN
fnp-3806	3515	10	,	,	PUNCT
fnp-3806	3515	11	et	et	PROPN
fnp-3806	3515	12	al	al	PROPN
fnp-3806	3515	13	.	.	PROPN
fnp-3806	3515	14	differential	differential	ADJ
fnp-3806	3515	15	cell	cell	NOUN
fnp-3806	3515	16	proliferation	proliferation	NOUN
fnp-3806	3515	17	in	in	ADP
fnp-3806	3515	18	the	the	DET
fnp-3806	3515	19	cortex	cortex	NOUN
fnp-3806	3515	20	of	of	ADP
fnp-3806	3515	21	the	the	DET
fnp-3806	3515	22	appsweps1de9	appsweps1de9	PROPN
fnp-3806	3515	23	alzheimer	alzheimer	PROPN
fnp-3806	3515	24	’s	’s	PART
fnp-3806	3515	25	disease	disease	PROPN
fnp-3806	3515	26	mouse	mouse	NOUN
fnp-3806	3515	27	model	model	NOUN
fnp-3806	3515	28	.	.	PUNCT
fnp-3806	3516	1	glia	glia	PROPN
fnp-3806	3516	2	2012	2012	NUM
fnp-3806	3516	3	;	;	PUNCT
fnp-3806	3516	4	60	60	NUM
fnp-3806	3516	5	:	:	PUNCT
fnp-3806	3516	6	615	615	NUM
fnp-3806	3516	7	-	-	SYM
fnp-3806	3516	8	629	629	NUM
fnp-3806	3516	9	.	.	PUNCT
fnp-3806	3516	10	https://doi.org/10.1002/glia.22295	https://doi.org/10.1002/glia.22295	PROPN
fnp-3806	3516	11	dong	dong	PROPN
fnp-3806	3516	12	xx	xx	PROPN
fnp-3806	3516	13	,	,	PUNCT
fnp-3806	3516	14	zhang	zhang	PROPN
fnp-3806	3516	15	hy	hy	PROPN
fnp-3806	3516	16	,	,	PUNCT
fnp-3806	3516	17	li	li	PROPN
fnp-3806	3516	18	hy	hy	PROPN
fnp-3806	3516	19	,	,	PUNCT
fnp-3806	3516	20	et	et	PROPN
fnp-3806	3516	21	al	al	PROPN
fnp-3806	3516	22	.	.	PROPN
fnp-3806	3516	23	association	association	PROPN
fnp-3806	3516	24	between	between	ADP
fnp-3806	3516	25	alzheimer	alzheimer	PROPN
fnp-3806	3516	26	’s	’s	PART
fnp-3806	3516	27	disease	disease	NOUN
fnp-3806	3516	28	pathogenesis	pathogenesis	NOUN
fnp-3806	3516	29	and	and	CCONJ
fnp-3806	3516	30	early	early	ADJ
fnp-3806	3516	31	demyelination	demyelination	NOUN
fnp-3806	3516	32	and	and	CCONJ
fnp-3806	3516	33	oligodendrocyte	oligodendrocyte	ADJ
fnp-3806	3516	34	dysfunction	dysfunction	NOUN
fnp-3806	3516	35	.	.	PUNCT
fnp-3806	3517	1	neural	neural	ADJ
fnp-3806	3517	2	regen	regen	PROPN
fnp-3806	3517	3	res	res	PROPN
fnp-3806	3517	4	2018;13:908	2018;13:908	NOUN
fnp-3806	3517	5	-	-	PUNCT
fnp-3806	3517	6	914	914	NUM
fnp-3806	3517	7	.	.	PUNCT
fnp-3806	3518	1	https://doi.org/10.4103/1673-5374.232486	https://doi.org/10.4103/1673-5374.232486	PROPN
fnp-3806	3518	2	gu	gu	PROPN
fnp-3806	3518	3	l	l	PROPN
fnp-3806	3518	4	,	,	PUNCT
fnp-3806	3518	5	wu	wu	PROPN
fnp-3806	3518	6	d	d	PROPN
fnp-3806	3518	7	,	,	PUNCT
fnp-3806	3518	8	tang	tang	PROPN
fnp-3806	3518	9	x	x	NOUN
fnp-3806	3518	10	,	,	PUNCT
fnp-3806	3518	11	et	et	PROPN
fnp-3806	3518	12	al	al	PROPN
fnp-3806	3518	13	.	.	PROPN
fnp-3806	3518	14	myelin	myelin	NOUN
fnp-3806	3518	15	changes	change	NOUN
fnp-3806	3518	16	at	at	ADP
fnp-3806	3518	17	early	early	ADJ
fnp-3806	3518	18	stage	stage	NOUN
fnp-3806	3518	19	of	of	ADP
fnp-3806	3518	20	5xfad	5xfad	NUM
fnp-3806	3518	21	mice	mouse	NOUN
fnp-3806	3518	22	.	.	PUNCT
fnp-3806	3519	1	brain	brain	NOUN
fnp-3806	3519	2	res	re	NOUN
fnp-3806	3519	3	bull	bull	PROPN
fnp-3806	3519	4	2018	2018	NUM
fnp-3806	3519	5	;	;	PUNCT
fnp-3806	3519	6	137:285	137:285	NUM
fnp-3806	3519	7	-	-	SYM
fnp-3806	3519	8	293	293	NUM
fnp-3806	3519	9	.	.	PUNCT
fnp-3806	3520	1	https://doi.org/10.1016/j.brainresbull.2017.12.013	https://doi.org/10.1016/j.brainresbull.2017.12.013	PROPN
fnp-3806	3520	2	scheibel	scheibel	PROPN
fnp-3806	3520	3	ab	ab	PROPN
fnp-3806	3520	4	,	,	PUNCT
fnp-3806	3520	5	duong	duong	PROPN
fnp-3806	3520	6	th	th	PROPN
fnp-3806	3520	7	,	,	PUNCT
fnp-3806	3520	8	jacobs	jacobs	PROPN
fnp-3806	3520	9	r.	r.	PROPN
fnp-3806	3520	10	alzheimer	alzheimer	PROPN
fnp-3806	3520	11	's	's	PART
fnp-3806	3520	12	disease	disease	NOUN
fnp-3806	3520	13	as	as	ADP
fnp-3806	3520	14	a	a	DET
fnp-3806	3520	15	capillary	capillary	ADJ
fnp-3806	3520	16	dementia	dementia	NOUN
fnp-3806	3520	17	.	.	PUNCT
fnp-3806	3521	1	ann	ann	PROPN
fnp-3806	3521	2	med	med	PROPN
fnp-3806	3521	3	1989;21:103	1989;21:103	PROPN
fnp-3806	3521	4	-	-	SYM
fnp-3806	3521	5	107	107	NUM
fnp-3806	3521	6	.	.	PUNCT
fnp-3806	3522	1	https://doi.org/10.3109/07853898909149194	https://doi.org/10.3109/07853898909149194	PROPN
fnp-3806	3522	2	de	de	X
fnp-3806	3522	3	la	la	PROPN
fnp-3806	3522	4	torre	torre	PROPN
fnp-3806	3522	5	jc	jc	PROPN
fnp-3806	3522	6	.	.	PROPN
fnp-3806	3522	7	is	be	AUX
fnp-3806	3522	8	alzheimer	alzheimer	PROPN
fnp-3806	3522	9	’s	’s	PART
fnp-3806	3522	10	disease	disease	NOUN
fnp-3806	3522	11	a	a	DET
fnp-3806	3522	12	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3522	13	or	or	CCONJ
fnp-3806	3522	14	a	a	DET
fnp-3806	3522	15	vascular	vascular	ADJ
fnp-3806	3522	16	disorder	disorder	NOUN
fnp-3806	3522	17	?	?	PUNCT
fnp-3806	3523	1	data	datum	NOUN
fnp-3806	3523	2	,	,	PUNCT
fnp-3806	3523	3	dogma	dogma	NOUN
fnp-3806	3523	4	,	,	PUNCT
fnp-3806	3523	5	and	and	CCONJ
fnp-3806	3523	6	dialectics	dialectic	NOUN
fnp-3806	3523	7	.	.	PUNCT
fnp-3806	3524	1	lancet	lancet	PROPN
fnp-3806	3524	2	neurol	neurol	PROPN
fnp-3806	3524	3	2004;3:184	2004;3:184	PROPN
fnp-3806	3524	4	-	-	SYM
fnp-3806	3524	5	190	190	NUM
fnp-3806	3524	6	.	.	PUNCT
fnp-3806	3525	1	https://doi.org/10.1016/s1474-4422(04)00683-0	https://doi.org/10.1016/s1474-4422(04)00683-0	PROPN
fnp-3806	3525	2	de	de	X
fnp-3806	3525	3	la	la	PROPN
fnp-3806	3525	4	torre	torre	PROPN
fnp-3806	3525	5	jc	jc	PROPN
fnp-3806	3525	6	.	.	PROPN
fnp-3806	3525	7	alzheimer	alzheimer	PROPN
fnp-3806	3525	8	’s	’s	PART
fnp-3806	3525	9	disease	disease	NOUN
fnp-3806	3525	10	is	be	AUX
fnp-3806	3525	11	a	a	DET
fnp-3806	3525	12	vasocognopathy	vasocognopathy	NOUN
fnp-3806	3525	13	:	:	PUNCT
fnp-3806	3525	14	a	a	DET
fnp-3806	3525	15	new	new	ADJ
fnp-3806	3525	16	term	term	NOUN
fnp-3806	3525	17	to	to	PART
fnp-3806	3525	18	describe	describe	VERB
fnp-3806	3525	19	its	its	PRON
fnp-3806	3525	20	nature	nature	NOUN
fnp-3806	3525	21	.	.	PUNCT
fnp-3806	3526	1	neurol	neurol	NOUN
fnp-3806	3526	2	res	re	VERB
fnp-3806	3526	3	2004;26:517	2004;26:517	PROPN
fnp-3806	3526	4	-	-	SYM
fnp-3806	3526	5	524	524	NUM
fnp-3806	3526	6	.	.	PUNCT
fnp-3806	3526	7	https://doi.org/10.1179/016164104225016254	https://doi.org/10.1179/016164104225016254	X
fnp-3806	3527	1	henry	henry	PROPN
fnp-3806	3527	2	-	-	PUNCT
fnp-3806	3527	3	feugeas	feugeas	PROPN
fnp-3806	3527	4	mc	mc	PROPN
fnp-3806	3527	5	.	.	PROPN
fnp-3806	3527	6	alzheimer	alzheimer	PROPN
fnp-3806	3527	7	's	's	PART
fnp-3806	3527	8	disease	disease	NOUN
fnp-3806	3527	9	in	in	ADP
fnp-3806	3527	10	late	late	ADJ
fnp-3806	3527	11	-	-	PUNCT
fnp-3806	3527	12	life	life	NOUN
fnp-3806	3527	13	dementia	dementia	NOUN
fnp-3806	3527	14	:	:	PUNCT
fnp-3806	3527	15	a	a	DET
fnp-3806	3527	16	minor	minor	ADJ
fnp-3806	3527	17	toxic	toxic	ADJ
fnp-3806	3527	18	consequence	consequence	NOUN
fnp-3806	3527	19	of	of	ADP
fnp-3806	3527	20	devastating	devastate	VERB
fnp-3806	3527	21	cerebrovascular	cerebrovascular	ADJ
fnp-3806	3527	22	dysfunction	dysfunction	NOUN
fnp-3806	3527	23	.	.	PUNCT
fnp-3806	3528	1	med	med	ADJ
fnp-3806	3528	2	hypotheses	hypothesis	NOUN
fnp-3806	3528	3	2008;70:866	2008;70:866	PROPN
fnp-3806	3528	4	-	-	SYM
fnp-3806	3528	5	875	875	NUM
fnp-3806	3528	6	.	.	PUNCT
fnp-3806	3529	1	https://doi.org/10.1016/j.mehy.2007.07.027	https://doi.org/10.1016/j.mehy.2007.07.027	PROPN
fnp-3806	3529	2	østergaard	østergaard	NOUN
fnp-3806	3529	3	l	l	NOUN
fnp-3806	3529	4	,	,	PUNCT
fnp-3806	3529	5	aamand	aamand	NOUN
fnp-3806	3529	6	r	r	NOUN
fnp-3806	3529	7	,	,	PUNCT
fnp-3806	3529	8	gutiérrez	gutiérrez	NOUN
fnp-3806	3529	9	-	-	PUNCT
fnp-3806	3529	10	jiménez	jiménez	PROPN
fnp-3806	3529	11	e	e	NOUN
fnp-3806	3529	12	,	,	PUNCT
fnp-3806	3529	13	et	et	PROPN
fnp-3806	3529	14	al	al	PROPN
fnp-3806	3529	15	.	.	PUNCT
fnp-3806	3530	1	the	the	DET
fnp-3806	3530	2	capillary	capillary	ADJ
fnp-3806	3530	3	dysfunction	dysfunction	NOUN
fnp-3806	3530	4	hypothesis	hypothesis	NOUN
fnp-3806	3530	5	of	of	ADP
fnp-3806	3530	6	alzheimer	alzheimer	PROPN
fnp-3806	3530	7	's	's	PART
fnp-3806	3530	8	disease	disease	NOUN
fnp-3806	3530	9	.	.	PUNCT
fnp-3806	3531	1	neurobiol	neurobiol	PROPN
fnp-3806	3531	2	aging	age	VERB
fnp-3806	3531	3	2013	2013	NUM
fnp-3806	3531	4	;	;	PUNCT
fnp-3806	3531	5	34:1018	34:1018	NOUN
fnp-3806	3531	6	-	-	SYM
fnp-3806	3531	7	1031	1031	NUM
fnp-3806	3531	8	.	.	PUNCT
fnp-3806	3532	1	https://doi.org/10.1016/j.neurobiolaging.2012.09.011	https://doi.org/10.1016/j.neurobiolaging.2012.09.011	NUM
fnp-3806	3532	2	scheibel	scheibel	PROPN
fnp-3806	3532	3	ab	ab	PROPN
fnp-3806	3532	4	,	,	PUNCT
fnp-3806	3532	5	duong	duong	PROPN
fnp-3806	3532	6	th	th	X
fnp-3806	3532	7	,	,	PUNCT
fnp-3806	3532	8	tomiyasu	tomiyasu	PROPN
fnp-3806	3532	9	u.	u.	PROPN
fnp-3806	3532	10	denervation	denervation	PROPN
fnp-3806	3532	11	microangiopathy	microangiopathy	ADJ
fnp-3806	3532	12	in	in	ADP
fnp-3806	3532	13	senile	senile	ADJ
fnp-3806	3532	14	dementia	dementia	NOUN
fnp-3806	3532	15	,	,	PUNCT
fnp-3806	3532	16	alzheimer	alzheimer	PROPN
fnp-3806	3532	17	type	type	NOUN
fnp-3806	3532	18	.	.	PUNCT
fnp-3806	3533	1	alzheimer	alzheimer	PROPN
fnp-3806	3533	2	dis	dis	PROPN
fnp-3806	3533	3	assoc	assoc	PROPN
fnp-3806	3533	4	disord	disord	PROPN
fnp-3806	3533	5	1987;1:19	1987;1:19	PROPN
fnp-3806	3533	6	-	-	PUNCT
fnp-3806	3533	7	37	37	NUM
fnp-3806	3533	8	.	.	PUNCT
fnp-3806	3534	1	https://doi.org/10.1097/00002093-198701000-00004	https://doi.org/10.1097/00002093-198701000-00004	NOUN
fnp-3806	3534	2	farkas	farkas	PROPN
fnp-3806	3534	3	e	e	NOUN
fnp-3806	3534	4	,	,	PUNCT
fnp-3806	3534	5	luiten	luiten	PROPN
fnp-3806	3534	6	pg	pg	PROPN
fnp-3806	3534	7	.	.	PUNCT
fnp-3806	3535	1	cerebral	cerebral	ADJ
fnp-3806	3535	2	microvascular	microvascular	ADJ
fnp-3806	3535	3	pathology	pathology	NOUN
fnp-3806	3535	4	in	in	ADP
fnp-3806	3535	5	aging	aging	NOUN
fnp-3806	3535	6	and	and	CCONJ
fnp-3806	3535	7	alzheimer	alzheimer	PROPN
fnp-3806	3535	8	’s	’s	PART
fnp-3806	3535	9	disease	disease	NOUN
fnp-3806	3535	10	.	.	PUNCT
fnp-3806	3536	1	prog	prog	PROPN
fnp-3806	3536	2	neurobiol	neurobiol	PROPN
fnp-3806	3536	3	2001;64:575	2001;64:575	NUM
fnp-3806	3536	4	-	-	PUNCT
fnp-3806	3536	5	611	611	NUM
fnp-3806	3536	6	.	.	PUNCT
fnp-3806	3537	1	https://doi.org/10.1016/s0301-0082(00)00068-x	https://doi.org/10.1016/s0301-0082(00)00068-x	PROPN
fnp-3806	3537	2	jellinger	jellinger	PROPN
fnp-3806	3537	3	k.	k.	PROPN
fnp-3806	3537	4	alzheimer	alzheimer	PROPN
fnp-3806	3537	5	disease	disease	PROPN
fnp-3806	3537	6	and	and	CCONJ
fnp-3806	3537	7	cerebrovascular	cerebrovascular	ADJ
fnp-3806	3537	8	pathology	pathology	NOUN
fnp-3806	3537	9	:	:	PUNCT
fnp-3806	3537	10	an	an	DET
fnp-3806	3537	11	update	update	NOUN
fnp-3806	3537	12	.	.	PUNCT
fnp-3806	3538	1	j	j	PROPN
fnp-3806	3538	2	neural	neural	ADJ
fnp-3806	3538	3	transm	transm	PROPN
fnp-3806	3538	4	2002;109	2002;109	NUM
fnp-3806	3538	5	;	;	PUNCT
fnp-3806	3538	6	813	813	NUM
fnp-3806	3538	7	-	-	SYM
fnp-3806	3538	8	836	836	NUM
fnp-3806	3538	9	.	.	PUNCT
fnp-3806	3539	1	https://doi.org/10.1007/s007020200068	https://doi.org/10.1007/s007020200068	NUM
fnp-3806	3539	2	vinters	vinter	NOUN
fnp-3806	3539	3	hv	hv	PROPN
fnp-3806	3539	4	,	,	PUNCT
fnp-3806	3539	5	gilbert	gilbert	PROPN
fnp-3806	3539	6	jj	jj	PROPN
fnp-3806	3539	7	.	.	PROPN
fnp-3806	3539	8	cerebral	cerebral	ADJ
fnp-3806	3539	9	amyloid	amyloid	NOUN
fnp-3806	3539	10	angiopathy	angiopathy	NOUN
fnp-3806	3539	11	:	:	PUNCT
fnp-3806	3539	12	incidence	incidence	NOUN
fnp-3806	3539	13	and	and	CCONJ
fnp-3806	3539	14	complications	complication	NOUN
fnp-3806	3539	15	in	in	ADP
fnp-3806	3539	16	the	the	DET
fnp-3806	3539	17	aging	age	VERB
fnp-3806	3539	18	brain	brain	NOUN
fnp-3806	3539	19	.	.	PUNCT
fnp-3806	3540	1	ii	ii	PROPN
fnp-3806	3540	2	.	.	PUNCT
fnp-3806	3541	1	the	the	DET
fnp-3806	3541	2	distribution	distribution	NOUN
fnp-3806	3541	3	of	of	ADP
fnp-3806	3541	4	amyloid	amyloid	NOUN
fnp-3806	3541	5	vascular	vascular	ADJ
fnp-3806	3541	6	changes	change	NOUN
fnp-3806	3541	7	.	.	PUNCT
fnp-3806	3542	1	stroke	stroke	NOUN
fnp-3806	3542	2	1983;14:924	1983;14:924	NOUN
fnp-3806	3542	3	-	-	SYM
fnp-3806	3542	4	928	928	NUM
fnp-3806	3542	5	.	.	PUNCT
fnp-3806	3543	1	https://doi.org/10.1161/01.str.14.6.924	https://doi.org/10.1161/01.str.14.6.924	PROPN
fnp-3806	3543	2	kalaria	kalaria	PROPN
fnp-3806	3543	3	rn	rn	PROPN
fnp-3806	3543	4	,	,	PUNCT
fnp-3806	3543	5	premkumar	premkumar	PROPN
fnp-3806	3543	6	dr	dr	PROPN
fnp-3806	3543	7	,	,	PUNCT
fnp-3806	3543	8	pax	pax	PROPN
fnp-3806	3543	9	ab	ab	PROPN
fnp-3806	3543	10	,	,	PUNCT
fnp-3806	3543	11	et	et	PROPN
fnp-3806	3543	12	al	al	PROPN
fnp-3806	3543	13	.	.	PUNCT
fnp-3806	3543	14	production	production	NOUN
fnp-3806	3543	15	and	and	CCONJ
fnp-3806	3543	16	increased	increase	VERB
fnp-3806	3543	17	detection	detection	NOUN
fnp-3806	3543	18	of	of	ADP
fnp-3806	3543	19	amyloid	amyloid	NOUN
fnp-3806	3543	20	beta	beta	NOUN
fnp-3806	3543	21	protein	protein	NOUN
fnp-3806	3543	22	and	and	CCONJ
fnp-3806	3543	23	amyloidogenic	amyloidogenic	ADJ
fnp-3806	3543	24	fragments	fragment	NOUN
fnp-3806	3543	25	in	in	ADP
fnp-3806	3543	26	brain	brain	NOUN
fnp-3806	3543	27	microvessels	microvessel	NOUN
fnp-3806	3543	28	,	,	PUNCT
fnp-3806	3543	29	meningeal	meningeal	ADJ
fnp-3806	3543	30	vessels	vessel	NOUN
fnp-3806	3543	31	and	and	CCONJ
fnp-3806	3543	32	choroids	choroid	VERB
fnp-3806	3543	33	plexus	plexus	NOUN
fnp-3806	3543	34	in	in	ADP
fnp-3806	3543	35	alzheimer	alzheimer	PROPN
fnp-3806	3543	36	's	's	PART
fnp-3806	3543	37	disease	disease	NOUN
fnp-3806	3543	38	.	.	PUNCT
fnp-3806	3544	1	mol	mol	ADP
fnp-3806	3544	2	brain	brain	NOUN
fnp-3806	3544	3	res	re	NOUN
fnp-3806	3544	4	1996;35:58–68	1996;35:58–68	NUM
fnp-3806	3544	5	.	.	PUNCT
fnp-3806	3545	1	https://doi.org/10.1016/0169-328x(95)00180-z	https://doi.org/10.1016/0169-328x(95)00180-z	PROPN
fnp-3806	3545	2	buée	buée	VERB
fnp-3806	3545	3	l	l	NOUN
fnp-3806	3545	4	,	,	PUNCT
fnp-3806	3545	5	hof	hof	PROPN
fnp-3806	3545	6	pr	pr	NOUN
fnp-3806	3545	7	,	,	PUNCT
fnp-3806	3545	8	bouras	boura	NOUN
fnp-3806	3545	9	c	c	NOUN
fnp-3806	3545	10	,	,	PUNCT
fnp-3806	3545	11	et	et	PROPN
fnp-3806	3545	12	al	al	PROPN
fnp-3806	3545	13	.	.	PUNCT
fnp-3806	3545	14	pathological	pathological	ADJ
fnp-3806	3545	15	alterations	alteration	NOUN
fnp-3806	3545	16	of	of	ADP
fnp-3806	3545	17	the	the	DET
fnp-3806	3545	18	cerebral	cerebral	ADJ
fnp-3806	3545	19	microvasculature	microvasculature	NOUN
fnp-3806	3545	20	in	in	ADP
fnp-3806	3545	21	alzheimer	alzheimer	PROPN
fnp-3806	3545	22	's	's	PART
fnp-3806	3545	23	disease	disease	NOUN
fnp-3806	3545	24	and	and	CCONJ
fnp-3806	3545	25	related	related	ADJ
fnp-3806	3545	26	dementing	dementing	NOUN
fnp-3806	3545	27	disorders	disorder	NOUN
fnp-3806	3545	28	.	.	PUNCT
fnp-3806	3546	1	acta	acta	PROPN
fnp-3806	3546	2	neuropathol	neuropathol	PROPN
fnp-3806	3546	3	1994;87:469	1994;87:469	PROPN
fnp-3806	3546	4	-	-	PROPN
fnp-3806	3546	5	480	480	NUM
fnp-3806	3546	6	.	.	PUNCT
fnp-3806	3547	1	https://doi.org/10.1007/bf00294173	https://doi.org/10.1007/bf00294173	PROPN
fnp-3806	3547	2	castellani	castellani	PROPN
fnp-3806	3547	3	rj	rj	PROPN
fnp-3806	3547	4	,	,	PUNCT
fnp-3806	3547	5	smith	smith	PROPN
fnp-3806	3547	6	ma	ma	PROPN
fnp-3806	3547	7	,	,	PUNCT
fnp-3806	3547	8	perry	perry	PROPN
fnp-3806	3547	9	g	g	PROPN
fnp-3806	3547	10	,	,	PUNCT
fnp-3806	3547	11	et	et	PROPN
fnp-3806	3547	12	al	al	PROPN
fnp-3806	3547	13	.	.	PROPN
fnp-3806	3547	14	cerebral	cerebral	ADJ
fnp-3806	3547	15	amyloid	amyloid	NOUN
fnp-3806	3547	16	angiopathy	angiopathy	NOUN
fnp-3806	3547	17	:	:	PUNCT
fnp-3806	3547	18	major	major	ADJ
fnp-3806	3547	19	contributor	contributor	NOUN
fnp-3806	3547	20	or	or	CCONJ
fnp-3806	3547	21	decorative	decorative	ADJ
fnp-3806	3547	22	response	response	NOUN
fnp-3806	3547	23	to	to	ADP
fnp-3806	3547	24	alzheimer	alzheimer	PROPN
fnp-3806	3547	25	's	's	PART
fnp-3806	3547	26	disease	disease	NOUN
fnp-3806	3547	27	pathogenesis	pathogenesis	NOUN
fnp-3806	3547	28	.	.	PUNCT
fnp-3806	3548	1	neurobiol	neurobiol	PROPN
fnp-3806	3548	2	aging	age	VERB
fnp-3806	3548	3	2004;25:599	2004;25:599	NUM
fnp-3806	3548	4	-	-	SYM
fnp-3806	3548	5	602	602	NUM
fnp-3806	3548	6	.	.	PUNCT
fnp-3806	3549	1	https://doi.org/10.1016/j.neurobiolaging.2003.12.019	https://doi.org/10.1016/j.neurobiolaging.2003.12.019	PROPN
fnp-3806	3549	2	thal	thal	PROPN
fnp-3806	3549	3	dr	dr	PROPN
fnp-3806	3549	4	,	,	PUNCT
fnp-3806	3549	5	griffin	griffin	PROPN
fnp-3806	3549	6	wst	wst	PROPN
fnp-3806	3549	7	,	,	PUNCT
fnp-3806	3549	8	de	de	PROPN
fnp-3806	3549	9	vos	vos	PROPN
fnp-3806	3549	10	rai	rai	PROPN
fnp-3806	3549	11	,	,	PUNCT
fnp-3806	3549	12	et	et	PROPN
fnp-3806	3549	13	al	al	PROPN
fnp-3806	3549	14	.	.	PROPN
fnp-3806	3549	15	cerebral	cerebral	ADJ
fnp-3806	3549	16	amyloid	amyloid	NOUN
fnp-3806	3549	17	angioapthy	angioapthy	NOUN
fnp-3806	3549	18	and	and	CCONJ
fnp-3806	3549	19	its	its	PRON
fnp-3806	3549	20	relationship	relationship	NOUN
fnp-3806	3549	21	to	to	ADP
fnp-3806	3549	22	alzheimer	alzheimer	PROPN
fnp-3806	3549	23	’s	’s	PART
fnp-3806	3549	24	disease	disease	NOUN
fnp-3806	3549	25	.	.	PUNCT
fnp-3806	3550	1	acta	acta	PROPN
fnp-3806	3550	2	neuropathol	neuropathol	PROPN
fnp-3806	3550	3	2008;115:599	2008;115:599	NUM
fnp-3806	3550	4	-	-	SYM
fnp-3806	3550	5	609	609	NUM
fnp-3806	3550	6	.	.	PUNCT
fnp-3806	3551	1	https://doi.org/10.1007/s00401-008-0366-2	https://doi.org/10.1007/s00401-008-0366-2	PROPN
fnp-3806	3551	2	weller	weller	PROPN
fnp-3806	3551	3	ro	ro	PROPN
fnp-3806	3551	4	,	,	PUNCT
fnp-3806	3551	5	subash	subash	PROPN
fnp-3806	3551	6	m	m	PROPN
fnp-3806	3551	7	,	,	PUNCT
fnp-3806	3551	8	preston	preston	PROPN
fnp-3806	3551	9	sd	sd	PROPN
fnp-3806	3551	10	,	,	PUNCT
fnp-3806	3551	11	et	et	PROPN
fnp-3806	3551	12	al	al	PROPN
fnp-3806	3551	13	.	.	PUNCT
fnp-3806	3551	14	perivascular	perivascular	ADJ
fnp-3806	3551	15	drainage	drainage	NOUN
fnp-3806	3551	16	of	of	ADP
fnp-3806	3551	17	amyloid	amyloid	NOUN
fnp-3806	3551	18	-	-	PUNCT
fnp-3806	3551	19	beta	beta	ADJ
fnp-3806	3551	20	peptides	peptide	NOUN
fnp-3806	3551	21	from	from	ADP
fnp-3806	3551	22	the	the	DET
fnp-3806	3551	23	brain	brain	NOUN
fnp-3806	3551	24	and	and	CCONJ
fnp-3806	3551	25	its	its	PRON
fnp-3806	3551	26	failure	failure	NOUN
fnp-3806	3551	27	in	in	ADP
fnp-3806	3551	28	cerebral	cerebral	ADJ
fnp-3806	3551	29	amyloid	amyloid	NOUN
fnp-3806	3551	30	angiopathy	angiopathy	NOUN
fnp-3806	3551	31	and	and	CCONJ
fnp-3806	3551	32	alzheimer	alzheimer	PROPN
fnp-3806	3551	33	’s	’s	PART
fnp-3806	3551	34	disease	disease	NOUN
fnp-3806	3551	35	.	.	PUNCT
fnp-3806	3552	1	brain	brain	NOUN
fnp-3806	3552	2	pathol	pathol	NOUN
fnp-3806	3552	3	2008;18:253	2008;18:253	NUM
fnp-3806	3552	4	-	-	SYM
fnp-3806	3552	5	266	266	NUM
fnp-3806	3552	6	.	.	PUNCT
fnp-3806	3553	1	https://doi.org/10.1111/j.1750-3639.2008.00133.x	https://doi.org/10.1111/j.1750-3639.2008.00133.x	X
fnp-3806	3553	2	weller	weller	PROPN
fnp-3806	3553	3	ro	ro	PROPN
fnp-3806	3553	4	,	,	PUNCT
fnp-3806	3553	5	boche	boche	PROPN
fnp-3806	3553	6	d	d	PROPN
fnp-3806	3553	7	,	,	PUNCT
fnp-3806	3553	8	nicoll	nicoll	PROPN
fnp-3806	3553	9	ja	ja	PROPN
fnp-3806	3553	10	.	.	PROPN
fnp-3806	3553	11	microvasculature	microvasculature	NOUN
fnp-3806	3553	12	changes	change	NOUN
fnp-3806	3553	13	and	and	CCONJ
fnp-3806	3553	14	cerebral	cerebral	ADJ
fnp-3806	3553	15	amyloid	amyloid	NOUN
fnp-3806	3553	16	angiopathy	angiopathy	NOUN
fnp-3806	3553	17	in	in	ADP
fnp-3806	3553	18	alzheimer	alzheimer	PROPN
fnp-3806	3553	19	’s	’s	PART
fnp-3806	3553	20	diseaseand	diseaseand	NOUN
fnp-3806	3553	21	their	their	PRON
fnp-3806	3553	22	potential	potential	ADJ
fnp-3806	3553	23	impact	impact	NOUN
fnp-3806	3553	24	on	on	ADP
fnp-3806	3553	25	therapy	therapy	NOUN
fnp-3806	3553	26	.	.	PUNCT
fnp-3806	3554	1	acta	acta	PROPN
fnp-3806	3554	2	neuropathol	neuropathol	PROPN
fnp-3806	3554	3	2009;118:87	2009;118:87	NUM
fnp-3806	3554	4	-	-	SYM
fnp-3806	3554	5	102	102	NUM
fnp-3806	3554	6	.	.	PUNCT
fnp-3806	3555	1	https://doi.org/10.1007/s00401-009-0498-z	https://doi.org/10.1007/s00401-009-0498-z	PROPN
fnp-3806	3555	2	soontornniyomkij	soontornniyomkij	PROPN
fnp-3806	3555	3	v	v	PROPN
fnp-3806	3555	4	,	,	PUNCT
fnp-3806	3555	5	choi	choi	NOUN
fnp-3806	3555	6	c	c	NOUN
fnp-3806	3555	7	,	,	PUNCT
fnp-3806	3555	8	pomakian	pomakian	PROPN
fnp-3806	3555	9	j	j	PROPN
fnp-3806	3555	10	,	,	PUNCT
fnp-3806	3555	11	et	et	PROPN
fnp-3806	3555	12	al	al	PROPN
fnp-3806	3555	13	.	.	PROPN
fnp-3806	3555	14	high	high	ADJ
fnp-3806	3555	15	-	-	PUNCT
fnp-3806	3555	16	definition	definition	NOUN
fnp-3806	3555	17	characterization	characterization	NOUN
fnp-3806	3555	18	of	of	ADP
fnp-3806	3555	19	cerebral	cerebral	ADJ
fnp-3806	3555	20	beta	beta	NOUN
fnp-3806	3555	21	-	-	PUNCT
fnp-3806	3555	22	amyloid	amyloid	NOUN
fnp-3806	3555	23	angiopathy	angiopathy	NOUN
fnp-3806	3555	24	in	in	ADP
fnp-3806	3555	25	alzheimer	alzheimer	PROPN
fnp-3806	3555	26	's	's	PART
fnp-3806	3555	27	disease	disease	NOUN
fnp-3806	3555	28	.	.	PUNCT
fnp-3806	3556	1	hum	hum	PROPN
fnp-3806	3556	2	pathol	pathol	VERB
fnp-3806	3556	3	2010;41:1601	2010;41:1601	PROPN
fnp-3806	3556	4	-	-	PROPN
fnp-3806	3556	5	1608	1608	NUM
fnp-3806	3556	6	.	.	PUNCT
fnp-3806	3557	1	https://doi.org/10.1016/j.humpath.2010.04.011	https://doi.org/10.1016/j.humpath.2010.04.011	PROPN
fnp-3806	3557	2	hunter	hunter	PROPN
fnp-3806	3557	3	jm	jm	PROPN
fnp-3806	3557	4	,	,	PUNCT
fnp-3806	3557	5	kwan	kwan	PROPN
fnp-3806	3557	6	j	j	PROPN
fnp-3806	3557	7	,	,	PUNCT
fnp-3806	3557	8	malek	malek	PROPN
fnp-3806	3557	9	-	-	PUNCT
fnp-3806	3557	10	ahmadi	ahmadi	PROPN
fnp-3806	3557	11	m	m	PROPN
fnp-3806	3557	12	,	,	PUNCT
fnp-3806	3557	13	et	et	PROPN
fnp-3806	3557	14	al	al	PROPN
fnp-3806	3557	15	.	.	PROPN
fnp-3806	3558	1	morphological	morphological	ADJ
fnp-3806	3558	2	and	and	CCONJ
fnp-3806	3558	3	pathological	pathological	ADJ
fnp-3806	3558	4	evolution	evolution	NOUN
fnp-3806	3558	5	of	of	ADP
fnp-3806	3558	6	the	the	DET
fnp-3806	3558	7	brain	brain	NOUN
fnp-3806	3558	8	microcirculation	microcirculation	NOUN
fnp-3806	3558	9	in	in	ADP
fnp-3806	3558	10	aging	aging	NOUN
fnp-3806	3558	11	and	and	CCONJ
fnp-3806	3558	12	alzheimer	alzheimer	NOUN
fnp-3806	3558	13	's	's	PART
fnp-3806	3558	14	disease	disease	NOUN
fnp-3806	3558	15	.	.	PUNCT
fnp-3806	3559	1	plos	plos	PROPN
fnp-3806	3559	2	one	one	NUM
fnp-3806	3559	3	2012;7	2012;7	NOUN
fnp-3806	3559	4	:	:	PUNCT
fnp-3806	3559	5	e36893	e36893	NOUN
fnp-3806	3559	6	.	.	PUNCT
fnp-3806	3560	1	https://doi.org/10.1371/journal.pone.0036893	https://doi.org/10.1371/journal.pone.0036893	PROPN
fnp-3806	3560	2	magaki	magaki	PROPN
fnp-3806	3560	3	s	s	PROPN
fnp-3806	3560	4	,	,	PUNCT
fnp-3806	3560	5	tang	tang	PROPN
fnp-3806	3560	6	z	z	PROPN
fnp-3806	3560	7	,	,	PUNCT
fnp-3806	3560	8	tung	tung	PROPN
fnp-3806	3560	9	s	s	PROPN
fnp-3806	3560	10	,	,	PUNCT
fnp-3806	3560	11	et	et	PROPN
fnp-3806	3560	12	al	al	PROPN
fnp-3806	3560	13	.	.	PUNCT
fnp-3806	3561	1	the	the	DET
fnp-3806	3561	2	effects	effect	NOUN
fnp-3806	3561	3	of	of	ADP
fnp-3806	3561	4	cerebral	cerebral	ADJ
fnp-3806	3561	5	amyloid	amyloid	NOUN
fnp-3806	3561	6	angiopathy	angiopathy	NOUN
fnp-3806	3561	7	on	on	ADP
fnp-3806	3561	8	integrity	integrity	NOUN
fnp-3806	3561	9	of	of	ADP
fnp-3806	3561	10	the	the	DET
fnp-3806	3561	11	blood	blood	NOUN
fnp-3806	3561	12	-	-	PUNCT
fnp-3806	3561	13	brain	brain	NOUN
fnp-3806	3561	14	barrier	barrier	NOUN
fnp-3806	3561	15	.	.	PUNCT
fnp-3806	3562	1	neurobiol	neurobiol	PROPN
fnp-3806	3562	2	aging	age	VERB
fnp-3806	3562	3	2018;70:70	2018;70:70	NUM
fnp-3806	3562	4	-	-	SYM
fnp-3806	3562	5	77	77	NUM
fnp-3806	3562	6	.	.	PUNCT
fnp-3806	3563	1	https://doi.org/10.1016/j.neurobiolaging.2018.06.004	https://doi.org/10.1016/j.neurobiolaging.2018.06.004	PROPN
fnp-3806	3563	2	jäkel	jäkel	PROPN
fnp-3806	3563	3	l	l	PROPN
fnp-3806	3563	4	,	,	PUNCT
fnp-3806	3563	5	de	de	PROPN
fnp-3806	3563	6	kort	kort	PROPN
fnp-3806	3563	7	am	am	PROPN
fnp-3806	3563	8	,	,	PUNCT
fnp-3806	3563	9	klijn	klijn	PROPN
fnp-3806	3563	10	cjm	cjm	PROPN
fnp-3806	3563	11	,	,	PUNCT
fnp-3806	3563	12	et	et	PROPN
fnp-3806	3563	13	al	al	PROPN
fnp-3806	3563	14	.	.	PUNCT
fnp-3806	3563	15	prevalence	prevalence	NOUN
fnp-3806	3563	16	of	of	ADP
fnp-3806	3563	17	cerebral	cerebral	ADJ
fnp-3806	3563	18	amyloid	amyloid	NOUN
fnp-3806	3563	19	angiopathy	angiopathy	NOUN
fnp-3806	3563	20	:	:	PUNCT
fnp-3806	3563	21	a	a	DET
fnp-3806	3563	22	systematic	systematic	ADJ
fnp-3806	3563	23	review	review	NOUN
fnp-3806	3563	24	and	and	CCONJ
fnp-3806	3563	25	meta	meta	ADJ
fnp-3806	3563	26	-	-	PUNCT
fnp-3806	3563	27	analysis	analysis	NOUN
fnp-3806	3563	28	.	.	PUNCT
fnp-3806	3564	1	alzheimers	alzheimers	PROPN
fnp-3806	3564	2	dement	dement	VERB
fnp-3806	3564	3	2022;18:10	2022;18:10	PROPN
fnp-3806	3564	4	-	-	SYM
fnp-3806	3564	5	28	28	NUM
fnp-3806	3564	6	.	.	PUNCT
fnp-3806	3565	1	https://doi.org/10.1002/alz.12366	https://doi.org/10.1002/alz.12366	VERB
fnp-3806	3565	2	apátiga	apátiga	ADJ
fnp-3806	3565	3	-	-	PUNCT
fnp-3806	3565	4	pérez	pérez	NOUN
fnp-3806	3565	5	r	r	NOUN
fnp-3806	3565	6	,	,	PUNCT
fnp-3806	3565	7	soto	soto	PROPN
fnp-3806	3565	8	-	-	PUNCT
fnp-3806	3565	9	rojas	rojas	PROPN
fnp-3806	3565	10	lo	lo	PROPN
fnp-3806	3565	11	,	,	PUNCT
fnp-3806	3565	12	campa	campa	PROPN
fnp-3806	3565	13	-	-	PUNCT
fnp-3806	3565	14	córdoba	córdoba	PROPN
fnp-3806	3565	15	bb	bb	PROPN
fnp-3806	3565	16	,	,	PUNCT
fnp-3806	3565	17	et	et	PROPN
fnp-3806	3565	18	al	al	PROPN
fnp-3806	3565	19	.	.	PUNCT
fnp-3806	3565	20	neurovascular	neurovascular	ADJ
fnp-3806	3565	21	dysfunction	dysfunction	NOUN
fnp-3806	3565	22	and	and	CCONJ
fnp-3806	3565	23	vascular	vascular	ADJ
fnp-3806	3565	24	amyloid	amyloid	NOUN
fnp-3806	3565	25	accumulation	accumulation	NOUN
fnp-3806	3565	26	as	as	ADP
fnp-3806	3565	27	early	early	ADJ
fnp-3806	3565	28	events	event	NOUN
fnp-3806	3565	29	in	in	ADP
fnp-3806	3565	30	alzheimer	alzheimer	PROPN
fnp-3806	3565	31	's	's	PART
fnp-3806	3565	32	disease	disease	NOUN
fnp-3806	3565	33	.	.	PUNCT
fnp-3806	3566	1	metab	metab	ADJ
fnp-3806	3566	2	brain	brain	NOUN
fnp-3806	3566	3	dis	dis	PROPN
fnp-3806	3566	4	2022;37:39	2022;37:39	NUM
fnp-3806	3566	5	-	-	SYM
fnp-3806	3566	6	50	50	NUM
fnp-3806	3566	7	.	.	PUNCT
fnp-3806	3567	1	https://doi.org/10.1007/s11011-021-00814-4	https://doi.org/10.1007/s11011-021-00814-4	NUM
fnp-3806	3567	2	iadecola	iadecola	PROPN
fnp-3806	3567	3	c.	c.	PROPN
fnp-3806	3567	4	neurovascular	neurovascular	PROPN
fnp-3806	3567	5	regulation	regulation	NOUN
fnp-3806	3567	6	in	in	ADP
fnp-3806	3567	7	the	the	DET
fnp-3806	3567	8	normal	normal	ADJ
fnp-3806	3567	9	brain	brain	NOUN
fnp-3806	3567	10	and	and	CCONJ
fnp-3806	3567	11	in	in	ADP
fnp-3806	3567	12	alzheimer	alzheimer	PROPN
fnp-3806	3567	13	's	's	PART
fnp-3806	3567	14	disease	disease	NOUN
fnp-3806	3567	15	.	.	PUNCT
fnp-3806	3568	1	nat	nat	PROPN
fnp-3806	3568	2	rev	rev	VERB
fnp-3806	3568	3	neurosc	neurosc	PROPN
fnp-3806	3568	4	2004;5:347	2004;5:347	PROPN
fnp-3806	3568	5	-	-	PUNCT
fnp-3806	3568	6	360	360	NUM
fnp-3806	3568	7	.	.	PUNCT
fnp-3806	3569	1	https://doi.org/10.1038/nrn1387	https://doi.org/10.1038/nrn1387	NOUN
fnp-3806	3569	2	johnson	johnson	PROPN
fnp-3806	3569	3	na	na	PROPN
fnp-3806	3569	4	,	,	PUNCT
fnp-3806	3569	5	jahng	jahng	PROPN
fnp-3806	3569	6	gh	gh	PROPN
fnp-3806	3569	7	,	,	PUNCT
fnp-3806	3569	8	weiner	weiner	NOUN
fnp-3806	3569	9	mw	mw	PROPN
fnp-3806	3569	10	,	,	PUNCT
fnp-3806	3569	11	pattern	pattern	NOUN
fnp-3806	3569	12	of	of	ADP
fnp-3806	3569	13	cerebral	cerebral	ADJ
fnp-3806	3569	14	hypoperfusion	hypoperfusion	NOUN
fnp-3806	3569	15	in	in	ADP
fnp-3806	3569	16	alzheimer	alzheimer	PROPN
fnp-3806	3569	17	disease	disease	NOUN
fnp-3806	3569	18	and	and	CCONJ
fnp-3806	3569	19	mild	mild	ADJ
fnp-3806	3569	20	cognitive	cognitive	ADJ
fnp-3806	3569	21	impairment	impairment	NOUN
fnp-3806	3569	22	measured	measure	VERB
fnp-3806	3569	23	with	with	ADP
fnp-3806	3569	24	arterial	arterial	ADJ
fnp-3806	3569	25	spin	spin	NOUN
fnp-3806	3569	26	-	-	PUNCT
fnp-3806	3569	27	labeling	labeling	NOUN
fnp-3806	3569	28	mr	mr	PROPN
fnp-3806	3569	29	imaging	imaging	PROPN
fnp-3806	3569	30	:	:	PUNCT
fnp-3806	3569	31	initial	initial	ADJ
fnp-3806	3569	32	experience	experience	NOUN
fnp-3806	3569	33	.	.	PUNCT
fnp-3806	3570	1	radiology	radiology	NOUN
fnp-3806	3570	2	2005;234:851	2005;234:851	PROPN
fnp-3806	3570	3	-	-	SYM
fnp-3806	3570	4	859	859	NUM
fnp-3806	3570	5	.	.	PUNCT
fnp-3806	3571	1	https://doi.org/10.1148/radiol.23	https://doi.org/10.1148/radiol.23	PRON
fnp-3806	3571	2	3040197	3040197	NUM
fnp-3806	3571	3	.	.	PUNCT
fnp-3806	3572	1	sagare	sagare	PROPN
fnp-3806	3572	2	ap	ap	PROPN
fnp-3806	3572	3	,	,	PUNCT
fnp-3806	3572	4	bell	bell	PROPN
fnp-3806	3572	5	rd	rd	PROPN
fnp-3806	3572	6	,	,	PUNCT
fnp-3806	3572	7	zhao	zhao	PROPN
fnp-3806	3572	8	z	z	PROPN
fnp-3806	3572	9	,	,	PUNCT
fnp-3806	3572	10	et	et	PROPN
fnp-3806	3572	11	al	al	PROPN
fnp-3806	3572	12	.	.	PROPN
fnp-3806	3573	1	pericyte	pericyte	NOUN
fnp-3806	3573	2	loss	loss	NOUN
fnp-3806	3573	3	influences	influence	VERB
fnp-3806	3573	4	alzheimer	alzheimer	ADJ
fnp-3806	3573	5	-	-	PUNCT
fnp-3806	3573	6	like	like	ADJ
fnp-3806	3573	7	neurodegeneration	neurodegeneration	NOUN
fnp-3806	3573	8	in	in	ADP
fnp-3806	3573	9	mice	mouse	NOUN
fnp-3806	3573	10	.	.	PUNCT
fnp-3806	3574	1	nat	nat	PROPN
fnp-3806	3574	2	commun	commun	PROPN
fnp-3806	3574	3	2013;4:2932	2013;4:2932	PROPN
fnp-3806	3574	4	.	.	PUNCT
fnp-3806	3575	1	https://doi.org/10.1038/ncomms3932	https://doi.org/10.1038/ncomms3932	PROPN
fnp-3806	3575	2	franzblau	franzblau	PROPN
fnp-3806	3575	3	m	m	PROPN
fnp-3806	3575	4	,	,	PUNCT
fnp-3806	3575	5	gonzales	gonzales	PROPN
fnp-3806	3575	6	-	-	PUNCT
fnp-3806	3575	7	portillo	portillo	PROPN
fnp-3806	3575	8	c	c	PROPN
fnp-3806	3575	9	,	,	PUNCT
fnp-3806	3575	10	gonzales	gonzales	PROPN
fnp-3806	3575	11	-	-	PUNCT
fnp-3806	3575	12	portillo	portillo	PROPN
fnp-3806	3575	13	gs	gs	PROPN
fnp-3806	3575	14	,	,	PUNCT
fnp-3806	3575	15	et	et	PROPN
fnp-3806	3575	16	al	al	PROPN
fnp-3806	3575	17	.	.	PUNCT
fnp-3806	3575	18	vascular	vascular	ADJ
fnp-3806	3575	19	damage	damage	NOUN
fnp-3806	3575	20	:	:	PUNCT
fnp-3806	3575	21	a	a	DET
fnp-3806	3575	22	persisting	persist	VERB
fnp-3806	3575	23	pathology	pathology	NOUN
fnp-3806	3575	24	common	common	ADJ
fnp-3806	3575	25	to	to	ADP
fnp-3806	3575	26	alzheimer	alzheimer	PROPN
fnp-3806	3575	27	’s	’s	PART
fnp-3806	3575	28	disease	disease	NOUN
fnp-3806	3575	29	and	and	CCONJ
fnp-3806	3575	30	traumatic	traumatic	ADJ
fnp-3806	3575	31	brain	brain	NOUN
fnp-3806	3575	32	injury	injury	NOUN
fnp-3806	3575	33	.	.	PUNCT
fnp-3806	3576	1	med	med	ADJ
fnp-3806	3576	2	hypotheses	hypothesis	NOUN
fnp-3806	3576	3	2013;81:842	2013;81:842	NOUN
fnp-3806	3576	4	-	-	SYM
fnp-3806	3576	5	845	845	NUM
fnp-3806	3576	6	.	.	PUNCT
fnp-3806	3577	1	https://doi.org/10.1016/j.mehy.2013.09.012	https://doi.org/10.1016/j.mehy.2013.09.012	PROPN
fnp-3806	3577	2	nelson	nelson	PROPN
fnp-3806	3577	3	ar	ar	PROPN
fnp-3806	3577	4	,	,	PUNCT
fnp-3806	3577	5	sweeney	sweeney	PROPN
fnp-3806	3577	6	md	md	PROPN
fnp-3806	3577	7	,	,	PUNCT
fnp-3806	3577	8	sagare	sagare	PROPN
fnp-3806	3577	9	ap	ap	PROPN
fnp-3806	3577	10	,	,	PUNCT
fnp-3806	3577	11	et	et	PROPN
fnp-3806	3577	12	al	al	PROPN
fnp-3806	3577	13	.	.	PUNCT
fnp-3806	3577	14	neurovascular	neurovascular	ADJ
fnp-3806	3577	15	dysfunction	dysfunction	NOUN
fnp-3806	3577	16	and	and	CCONJ
fnp-3806	3577	17	neurodegeneration	neurodegeneration	NOUN
fnp-3806	3577	18	in	in	ADP
fnp-3806	3577	19	dementia	dementia	NOUN
fnp-3806	3577	20	and	and	CCONJ
fnp-3806	3577	21	alzheimer	alzheimer	PROPN
fnp-3806	3577	22	’s	’s	PART
fnp-3806	3577	23	disease	disease	NOUN
fnp-3806	3577	24	.	.	PUNCT
fnp-3806	3578	1	biochim	biochim	PROPN
fnp-3806	3578	2	biophys	biophy	NOUN
fnp-3806	3578	3	acta	acta	PROPN
fnp-3806	3578	4	2016;1862:887	2016;1862:887	NUM
fnp-3806	3578	5	-	-	SYM
fnp-3806	3578	6	900	900	NUM
fnp-3806	3578	7	.	.	PUNCT
fnp-3806	3579	1	https://doi.org/10.1016/j.bbadis.2015.12.016	https://doi.org/10.1016/j.bbadis.2015.12.016	PROPN
fnp-3806	3579	2	kisler	kisler	PROPN
fnp-3806	3579	3	k	k	PROPN
fnp-3806	3579	4	,	,	PUNCT
fnp-3806	3579	5	nelson	nelson	PROPN
fnp-3806	3579	6	ar	ar	PROPN
fnp-3806	3579	7	,	,	PUNCT
fnp-3806	3579	8	montagne	montagne	PROPN
fnp-3806	3579	9	a	a	PROPN
fnp-3806	3579	10	,	,	PUNCT
fnp-3806	3579	11	et	et	PROPN
fnp-3806	3579	12	al	al	PROPN
fnp-3806	3579	13	.	.	PROPN
fnp-3806	3579	14	cerebral	cerebral	ADJ
fnp-3806	3579	15	blood	blood	NOUN
fnp-3806	3579	16	flow	flow	NOUN
fnp-3806	3579	17	regulation	regulation	NOUN
fnp-3806	3579	18	and	and	CCONJ
fnp-3806	3579	19	neurovascular	neurovascular	ADJ
fnp-3806	3579	20	dysfunction	dysfunction	NOUN
fnp-3806	3579	21	in	in	ADP
fnp-3806	3579	22	alzheimer	alzheimer	PROPN
fnp-3806	3579	23	disease	disease	PROPN
fnp-3806	3579	24	.	.	PUNCT
fnp-3806	3580	1	nat	nat	PROPN
fnp-3806	3580	2	rev	rev	VERB
fnp-3806	3580	3	neurosci	neurosci	PROPN
fnp-3806	3580	4	2017;18:419	2017;18:419	PROPN
fnp-3806	3580	5	-	-	SYM
fnp-3806	3580	6	434	434	NUM
fnp-3806	3580	7	.	.	PUNCT
fnp-3806	3581	1	https://doi.org/10.1038/nrn.2017.48	https://doi.org/10.1038/nrn.2017.48	NOUN
fnp-3806	3581	2	leijenaar	leijenaar	PROPN
fnp-3806	3581	3	jf	jf	PROPN
fnp-3806	3581	4	,	,	PUNCT
fnp-3806	3581	5	van	van	PROPN
fnp-3806	3581	6	maurik	maurik	PROPN
fnp-3806	3581	7	is	be	AUX
fnp-3806	3581	8	,	,	PUNCT
fnp-3806	3581	9	kuijer	kuijer	PROPN
fnp-3806	3581	10	jpa	jpa	PROPN
fnp-3806	3581	11	,	,	PUNCT
fnp-3806	3581	12	et	et	PROPN
fnp-3806	3581	13	al	al	PROPN
fnp-3806	3581	14	.	.	PUNCT
fnp-3806	3582	1	lower	low	ADJ
fnp-3806	3582	2	cerebral	cerebral	ADJ
fnp-3806	3582	3	blood	blood	NOUN
fnp-3806	3582	4	flow	flow	NOUN
fnp-3806	3582	5	in	in	ADP
fnp-3806	3582	6	subjects	subject	NOUN
fnp-3806	3582	7	with	with	ADP
fnp-3806	3582	8	alzheimer	alzheimer	PROPN
fnp-3806	3582	9	’s	’s	PART
fnp-3806	3582	10	dementia	dementia	NOUN
fnp-3806	3582	11	,	,	PUNCT
fnp-3806	3582	12	mild	mild	ADJ
fnp-3806	3582	13	cognitive	cognitive	ADJ
fnp-3806	3582	14	impairment	impairment	NOUN
fnp-3806	3582	15	,	,	PUNCT
fnp-3806	3582	16	and	and	CCONJ
fnp-3806	3582	17	subjective	subjective	ADJ
fnp-3806	3582	18	cognitive	cognitive	ADJ
fnp-3806	3582	19	decline	decline	NOUN
fnp-3806	3582	20	using	use	VERB
fnp-3806	3582	21	two	two	NUM
fnp-3806	3582	22	-	-	PUNCT
fnp-3806	3582	23	dimensional	dimensional	ADJ
fnp-3806	3582	24	phase	phase	NOUN
fnp-3806	3582	25	-	-	PUNCT
fnp-3806	3582	26	contrast	contrast	NOUN
fnp-3806	3582	27	magnetic	magnetic	ADJ
fnp-3806	3582	28	resonance	resonance	NOUN
fnp-3806	3582	29	imaging	imaging	NOUN
fnp-3806	3582	30	.	.	PUNCT
fnp-3806	3583	1	alzheimers	alzheimers	PROPN
fnp-3806	3583	2	dement	dement	PROPN
fnp-3806	3583	3	2017;9:76	2017;9:76	PROPN
fnp-3806	3583	4	-	-	PUNCT
fnp-3806	3583	5	83	83	NUM
fnp-3806	3583	6	.	.	PUNCT
fnp-3806	3584	1	https://doi.org/10.1016/j.dadm.2017.10.001	https://doi.org/10.1016/j.dadm.2017.10.001	PROPN
fnp-3806	3584	2	yamazaki	yamazaki	PROPN
fnp-3806	3584	3	y	y	PROPN
fnp-3806	3584	4	,	,	PUNCT
fnp-3806	3584	5	kanekiyo	kanekiyo	PROPN
fnp-3806	3584	6	t.	t.	NOUN
fnp-3806	3584	7	blood	blood	NOUN
fnp-3806	3584	8	-	-	PUNCT
fnp-3806	3584	9	brain	brain	NOUN
fnp-3806	3584	10	barrier	barrier	NOUN
fnp-3806	3584	11	dysfunction	dysfunction	NOUN
fnp-3806	3584	12	and	and	CCONJ
fnp-3806	3584	13	the	the	DET
fnp-3806	3584	14	pathogenesis	pathogenesis	NOUN
fnp-3806	3584	15	of	of	ADP
fnp-3806	3584	16	alzheimer	alzheimer	PROPN
fnp-3806	3584	17	's	's	PART
fnp-3806	3584	18	disease	disease	NOUN
fnp-3806	3584	19	.	.	PUNCT
fnp-3806	3585	1	int	int	PROPN
fnp-3806	3585	2	j	j	PROPN
fnp-3806	3585	3	mol	mol	ADP
fnp-3806	3585	4	sci	sci	PROPN
fnp-3806	3585	5	2017;18:1965	2017;18:1965	PROPN
fnp-3806	3585	6	.	.	PUNCT
fnp-3806	3586	1	https://doi.org/10.3390/ijms18091965	https://doi.org/10.3390/ijms18091965	PROPN
fnp-3806	3586	2	rasmussen	rasmussen	PROPN
fnp-3806	3586	3	mk	mk	PROPN
fnp-3806	3586	4	,	,	PUNCT
fnp-3806	3586	5	mestre	mestre	PROPN
fnp-3806	3586	6	h	h	PROPN
fnp-3806	3586	7	,	,	PUNCT
fnp-3806	3586	8	nedergaard	nedergaard	ADJ
fnp-3806	3586	9	m.	m.	NOUN
fnp-3806	3586	10	the	the	DET
fnp-3806	3586	11	glymphatic	glymphatic	ADJ
fnp-3806	3586	12	pathway	pathway	NOUN
fnp-3806	3586	13	in	in	ADP
fnp-3806	3586	14	neurological	neurological	ADJ
fnp-3806	3586	15	disorders	disorder	NOUN
fnp-3806	3586	16	.	.	PUNCT
fnp-3806	3587	1	lancet	lancet	PROPN
fnp-3806	3587	2	neurol	neurol	PROPN
fnp-3806	3587	3	2018;17:1016	2018;17:1016	PROPN
fnp-3806	3587	4	-	-	SYM
fnp-3806	3587	5	1024	1024	NUM
fnp-3806	3587	6	.	.	PUNCT
fnp-3806	3588	1	https://doi.org/10.1016/s1474-4422(18)30318-1	https://doi.org/10.1016/s1474-4422(18)30318-1	PROPN
fnp-3806	3588	2	ahmad	ahmad	PROPN
fnp-3806	3588	3	a	a	PRON
fnp-3806	3588	4	,	,	PUNCT
fnp-3806	3588	5	patel	patel	PROPN
fnp-3806	3588	6	v	v	PROPN
fnp-3806	3588	7	,	,	PUNCT
fnp-3806	3588	8	xiao	xiao	PROPN
fnp-3806	3588	9	j	j	PROPN
fnp-3806	3588	10	,	,	PUNCT
fnp-3806	3588	11	et	et	PROPN
fnp-3806	3588	12	al	al	PROPN
fnp-3806	3588	13	.	.	PUNCT
fnp-3806	3589	1	the	the	DET
fnp-3806	3589	2	role	role	NOUN
fnp-3806	3589	3	of	of	ADP
fnp-3806	3589	4	neurovascular	neurovascular	ADJ
fnp-3806	3589	5	system	system	NOUN
fnp-3806	3589	6	in	in	ADP
fnp-3806	3589	7	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3589	8	diseases	disease	NOUN
fnp-3806	3589	9	.	.	PUNCT
fnp-3806	3590	1	mol	mol	ADP
fnp-3806	3590	2	neurobiol	neurobiol	PROPN
fnp-3806	3590	3	2020;57	2020;57	NUM
fnp-3806	3590	4	:	:	PUNCT
fnp-3806	3590	5	4373	4373	NUM
fnp-3806	3590	6	-	-	SYM
fnp-3806	3590	7	4393	4393	NUM
fnp-3806	3590	8	.	.	PUNCT
fnp-3806	3591	1	https://doi.org/10.1007/s12035-020-02023-z	https://doi.org/10.1007/s12035-020-02023-z	PROPN
fnp-3806	3591	2	sweeney	sweeney	PROPN
fnp-3806	3591	3	md	md	PROPN
fnp-3806	3591	4	,	,	PUNCT
fnp-3806	3591	5	montagne	montagne	PROPN
fnp-3806	3591	6	a	a	PROPN
fnp-3806	3591	7	,	,	PUNCT
fnp-3806	3591	8	sagare	sagare	PROPN
fnp-3806	3591	9	ap	ap	PROPN
fnp-3806	3591	10	,	,	PUNCT
fnp-3806	3591	11	et	et	PROPN
fnp-3806	3591	12	al	al	PROPN
fnp-3806	3591	13	.	.	PUNCT
fnp-3806	3591	14	vascular	vascular	ADJ
fnp-3806	3591	15	dysfunction	dysfunction	NOUN
fnp-3806	3591	16	:	:	PUNCT
fnp-3806	3591	17	the	the	DET
fnp-3806	3591	18	disregarded	disregarded	ADJ
fnp-3806	3591	19	partner	partner	NOUN
fnp-3806	3591	20	of	of	ADP
fnp-3806	3591	21	alzheimer	alzheimer	PROPN
fnp-3806	3591	22	's	's	PART
fnp-3806	3591	23	disease	disease	NOUN
fnp-3806	3591	24	.	.	PUNCT
fnp-3806	3592	1	alzheimers	alzheimers	PROPN
fnp-3806	3592	2	dement	dement	PROPN
fnp-3806	3592	3	2019;15:158	2019;15:158	PROPN
fnp-3806	3592	4	-	-	SYM
fnp-3806	3592	5	167	167	NUM
fnp-3806	3592	6	.	.	PUNCT
fnp-3806	3593	1	https://doi.org/10.1016/j.jalz.2018.07.222	https://doi.org/10.1016/j.jalz.2018.07.222	NOUN
fnp-3806	3593	2	kurz	kurz	PROPN
fnp-3806	3593	3	c	c	PROPN
fnp-3806	3593	4	,	,	PUNCT
fnp-3806	3593	5	walker	walker	PROPN
fnp-3806	3593	6	l	l	PROPN
fnp-3806	3593	7	,	,	PUNCT
fnp-3806	3593	8	rauchmann	rauchmann	PROPN
fnp-3806	3593	9	bs	bs	PROPN
fnp-3806	3593	10	,	,	PUNCT
fnp-3806	3593	11	et	et	PROPN
fnp-3806	3593	12	al	al	PROPN
fnp-3806	3593	13	.	.	PUNCT
fnp-3806	3594	1	dysfunction	dysfunction	NOUN
fnp-3806	3594	2	of	of	ADP
fnp-3806	3594	3	the	the	DET
fnp-3806	3594	4	blood	blood	NOUN
fnp-3806	3594	5	-	-	PUNCT
fnp-3806	3594	6	brain	brain	NOUN
fnp-3806	3594	7	barrier	barrier	NOUN
fnp-3806	3594	8	in	in	ADP
fnp-3806	3594	9	alzheimer	alzheimer	PROPN
fnp-3806	3594	10	’s	’s	PART
fnp-3806	3594	11	disease	disease	NOUN
fnp-3806	3594	12	:	:	PUNCT
fnp-3806	3594	13	evidence	evidence	NOUN
fnp-3806	3594	14	from	from	ADP
fnp-3806	3594	15	human	human	ADJ
fnp-3806	3594	16	studies	study	NOUN
fnp-3806	3594	17	.	.	PUNCT
fnp-3806	3595	1	neuropathol	neuropathol	PROPN
fnp-3806	3595	2	appl	appl	PROPN
fnp-3806	3595	3	neurobiol	neurobiol	PROPN
fnp-3806	3595	4	neuropathol	neuropathol	PROPN
fnp-3806	3595	5	appl	appl	PROPN
fnp-3806	3595	6	neurobiol	neurobiol	PROPN
fnp-3806	3595	7	2022;e12782	2022;e12782	NUM
fnp-3806	3595	8	.	.	PUNCT
fnp-3806	3596	1	https://doi.org/10.1111/nan.12782	https://doi.org/10.1111/nan.12782	PROPN
fnp-3806	3596	2	kalaria	kalaria	PROPN
fnp-3806	3596	3	rn	rn	PROPN
fnp-3806	3596	4	,	,	PUNCT
fnp-3806	3596	5	pax	pax	PROPN
fnp-3806	3596	6	ab	ab	PROPN
fnp-3806	3596	7	.	.	PROPN
fnp-3806	3596	8	increased	increase	VERB
fnp-3806	3596	9	collagen	collagen	NOUN
fnp-3806	3596	10	content	content	NOUN
fnp-3806	3596	11	of	of	ADP
fnp-3806	3596	12	cerebral	cerebral	ADJ
fnp-3806	3596	13	microvessels	microvessel	NOUN
fnp-3806	3596	14	in	in	ADP
fnp-3806	3596	15	alzheimer	alzheimer	PROPN
fnp-3806	3596	16	’s	’s	PART
fnp-3806	3596	17	disease	disease	NOUN
fnp-3806	3596	18	.	.	PUNCT
fnp-3806	3597	1	brain	brain	NOUN
fnp-3806	3597	2	res	re	NOUN
fnp-3806	3597	3	1995;705:349	1995;705:349	NUM
fnp-3806	3597	4	-	-	SYM
fnp-3806	3597	5	352	352	NUM
fnp-3806	3597	6	.	.	PUNCT
fnp-3806	3598	1	https://doi.org/10.1016/0006-8993(95)01250-8	https://doi.org/10.1016/0006-8993(95)01250-8	PROPN
fnp-3806	3598	2	verbeek	verbeek	NOUN
fnp-3806	3598	3	mm	mm	NOUN
fnp-3806	3598	4	,	,	PUNCT
fnp-3806	3598	5	otte	otte	NOUN
fnp-3806	3598	6	-	-	PUNCT
fnp-3806	3598	7	holler	holler	NOUN
fnp-3806	3599	1	i	i	PROPN
fnp-3806	3599	2	,	,	PUNCT
fnp-3806	3599	3	van	van	PROPN
fnp-3806	3599	4	den	den	PROPN
fnp-3806	3599	5	born	bear	VERB
fnp-3806	3599	6	j	j	PROPN
fnp-3806	3599	7	,	,	PUNCT
fnp-3806	3599	8	et	et	PROPN
fnp-3806	3599	9	al	al	PROPN
fnp-3806	3599	10	.	.	PUNCT
fnp-3806	3600	1	agrin	agrin	NOUN
fnp-3806	3600	2	is	be	AUX
fnp-3806	3600	3	a	a	DET
fnp-3806	3600	4	major	major	ADJ
fnp-3806	3600	5	heparan	heparan	ADJ
fnp-3806	3600	6	sulfate	sulfate	NOUN
fnp-3806	3600	7	proteoglycan	proteoglycan	NOUN
fnp-3806	3600	8	accumulating	accumulate	VERB
fnp-3806	3600	9	in	in	ADP
fnp-3806	3600	10	alzheimer	alzheimer	PROPN
fnp-3806	3600	11	's	's	PART
fnp-3806	3600	12	disease	disease	NOUN
fnp-3806	3600	13	brain	brain	NOUN
fnp-3806	3600	14	.	.	PUNCT
fnp-3806	3601	1	am	be	AUX
fnp-3806	3601	2	j	j	PROPN
fnp-3806	3601	3	pathol	pathol	NOUN
fnp-3806	3601	4	1999;155:2115	1999;155:2115	NUM
fnp-3806	3601	5	-	-	SYM
fnp-3806	3601	6	2125	2125	NUM
fnp-3806	3601	7	.	.	PUNCT
fnp-3806	3602	1	https://doi.org/10.1016/s0002-9440(10)65529-0	https://doi.org/10.1016/s0002-9440(10)65529-0	PROPN
fnp-3806	3602	2	berzin	berzin	PROPN
fnp-3806	3602	3	tm	tm	PROPN
fnp-3806	3602	4	,	,	PUNCT
fnp-3806	3602	5	zipser	zipser	PROPN
fnp-3806	3602	6	bd	bd	PROPN
fnp-3806	3602	7	,	,	PUNCT
fnp-3806	3602	8	rafii	rafii	PROPN
fnp-3806	3602	9	ms	ms	PROPN
fnp-3806	3602	10	,	,	PUNCT
fnp-3806	3602	11	et	et	PROPN
fnp-3806	3602	12	al	al	PROPN
fnp-3806	3602	13	.	.	PUNCT
fnp-3806	3603	1	agrin	agrin	NOUN
fnp-3806	3603	2	and	and	CCONJ
fnp-3806	3603	3	microvascular	microvascular	ADJ
fnp-3806	3603	4	damage	damage	NOUN
fnp-3806	3603	5	in	in	ADP
fnp-3806	3603	6	alzheimer	alzheimer	PROPN
fnp-3806	3603	7	’s	’s	PART
fnp-3806	3603	8	disease	disease	NOUN
fnp-3806	3603	9	.	.	PUNCT
fnp-3806	3604	1	neurobiol	neurobiol	PROPN
fnp-3806	3604	2	aging	age	VERB
fnp-3806	3604	3	2000;21:349	2000;21:349	NUM
fnp-3806	3604	4	-	-	SYM
fnp-3806	3604	5	355	355	NUM
fnp-3806	3604	6	.	.	PUNCT
fnp-3806	3605	1	https://doi.org/10.1016/s0197-4580(00)00121-4	https://doi.org/10.1016/s0197-4580(00)00121-4	PROPN
fnp-3806	3605	2	grammas	grammas	PROPN
fnp-3806	3605	3	p	p	PROPN
fnp-3806	3605	4	,	,	PUNCT
fnp-3806	3605	5	yamada	yamada	PROPN
fnp-3806	3605	6	m	m	PROPN
fnp-3806	3605	7	,	,	PUNCT
fnp-3806	3605	8	zlokovic	zlokovic	PROPN
fnp-3806	3605	9	b.	b.	PROPN
fnp-3806	3606	1	the	the	DET
fnp-3806	3606	2	cerebromicrovasculature	cerebromicrovasculature	NOUN
fnp-3806	3606	3	:	:	PUNCT
fnp-3806	3606	4	a	a	DET
fnp-3806	3606	5	key	key	ADJ
fnp-3806	3606	6	player	player	NOUN
fnp-3806	3606	7	in	in	ADP
fnp-3806	3606	8	the	the	DET
fnp-3806	3606	9	pathogenesis	pathogenesis	NOUN
fnp-3806	3606	10	of	of	ADP
fnp-3806	3606	11	alzheimer	alzheimer	PROPN
fnp-3806	3606	12	’s	’s	PART
fnp-3806	3606	13	disease	disease	NOUN
fnp-3806	3606	14	.	.	PUNCT
fnp-3806	3607	1	j	j	PROPN
fnp-3806	3607	2	alzheimers	alzheimers	PROPN
fnp-3806	3607	3	dis	dis	PROPN
fnp-3806	3607	4	2002;4:217	2002;4:217	NUM
fnp-3806	3607	5	-	-	PUNCT
fnp-3806	3607	6	223	223	NUM
fnp-3806	3607	7	.	.	PUNCT
fnp-3806	3608	1	https://doi.org/10.3233/jad-2002-4311	https://doi.org/10.3233/jad-2002-4311	PROPN
fnp-3806	3608	2	ervin	ervin	PROPN
fnp-3806	3608	3	jf	jf	PROPN
fnp-3806	3608	4	,	,	PUNCT
fnp-3806	3608	5	pannell	pannell	ADJ
fnp-3806	3608	6	c	c	NOUN
fnp-3806	3608	7	,	,	PUNCT
fnp-3806	3608	8	szymansky	szymansky	PROPN
fnp-3806	3608	9	m	m	PROPN
fnp-3806	3608	10	,	,	PUNCT
fnp-3806	3608	11	et	et	PROPN
fnp-3806	3608	12	al	al	PROPN
fnp-3806	3608	13	.	.	PROPN
fnp-3806	3608	14	vascular	vascular	ADJ
fnp-3806	3608	15	smooth	smooth	ADJ
fnp-3806	3608	16	muscle	muscle	NOUN
fnp-3806	3608	17	actin	actin	NOUN
fnp-3806	3608	18	is	be	AUX
fnp-3806	3608	19	reduced	reduce	VERB
fnp-3806	3608	20	in	in	ADP
fnp-3806	3608	21	alzheimer	alzheimer	PROPN
fnp-3806	3608	22	disease	disease	PROPN
fnp-3806	3608	23	brain	brain	NOUN
fnp-3806	3608	24	:	:	PUNCT
fnp-3806	3608	25	a	a	DET
fnp-3806	3608	26	quantitative	quantitative	ADJ
fnp-3806	3608	27	analysis	analysis	NOUN
fnp-3806	3608	28	.	.	PUNCT
fnp-3806	3609	1	j	j	PROPN
fnp-3806	3609	2	neuropathol	neuropathol	PROPN
fnp-3806	3609	3	exp	exp	PROPN
fnp-3806	3609	4	neurol	neurol	PROPN
fnp-3806	3609	5	2004;63:735	2004;63:735	PROPN
fnp-3806	3609	6	-	-	SYM
fnp-3806	3609	7	741	741	NUM
fnp-3806	3609	8	.	.	PUNCT
fnp-3806	3610	1	https://doi.org/10.1093/jnen/63.7.735	https://doi.org/10.1093/jnen/63.7.735	PROPN
fnp-3806	3610	2	bailey	bailey	PROPN
fnp-3806	3610	3	tl	tl	PROPN
fnp-3806	3610	4	,	,	PUNCT
fnp-3806	3610	5	rivara	rivara	PROPN
fnp-3806	3610	6	cb	cb	PROPN
fnp-3806	3610	7	,	,	PUNCT
fnp-3806	3610	8	rocher	rocher	PROPN
fnp-3806	3610	9	ab	ab	PROPN
fnp-3806	3610	10	,	,	PUNCT
fnp-3806	3610	11	et	et	PROPN
fnp-3806	3610	12	al	al	PROPN
fnp-3806	3610	13	.	.	PUNCT
fnp-3806	3611	1	the	the	DET
fnp-3806	3611	2	nature	nature	NOUN
fnp-3806	3611	3	and	and	CCONJ
fnp-3806	3611	4	effects	effect	NOUN
fnp-3806	3611	5	of	of	ADP
fnp-3806	3611	6	cortical	cortical	ADJ
fnp-3806	3611	7	microvascular	microvascular	ADJ
fnp-3806	3611	8	pathology	pathology	NOUN
fnp-3806	3611	9	in	in	ADP
fnp-3806	3611	10	aging	aging	NOUN
fnp-3806	3611	11	and	and	CCONJ
fnp-3806	3611	12	alzheimer	alzheimer	PROPN
fnp-3806	3611	13	’s	’s	PART
fnp-3806	3611	14	disease	disease	NOUN
fnp-3806	3611	15	.	.	PUNCT
fnp-3806	3612	1	neurol	neurol	NOUN
fnp-3806	3612	2	res	re	VERB
fnp-3806	3612	3	2004;26:573	2004;26:573	NOUN
fnp-3806	3612	4	-	-	SYM
fnp-3806	3612	5	578	578	NUM
fnp-3806	3612	6	.	.	PUNCT
fnp-3806	3613	1	https://doi.org/10.1179/016164104225016272	https://doi.org/10.1179/016164104225016272	PROPN
fnp-3806	3614	1	kalaria	kalaria	PROPN
fnp-3806	3614	2	rn	rn	PROPN
fnp-3806	3614	3	,	,	PUNCT
fnp-3806	3614	4	hedera	hedera	PROPN
fnp-3806	3614	5	p.	p.	PROPN
fnp-3806	3614	6	differential	differential	NOUN
fnp-3806	3614	7	degeneration	degeneration	NOUN
fnp-3806	3614	8	of	of	ADP
fnp-3806	3614	9	the	the	DET
fnp-3806	3614	10	cerebral	cerebral	ADJ
fnp-3806	3614	11	microvasculature	microvasculature	NOUN
fnp-3806	3614	12	in	in	ADP
fnp-3806	3614	13	alzheimer	alzheimer	PROPN
fnp-3806	3614	14	’s	’s	PART
fnp-3806	3614	15	disease	disease	NOUN
fnp-3806	3614	16	.	.	PUNCT
fnp-3806	3615	1	neuroreport	neuroreport	NOUN
fnp-3806	3615	2	1995;6:477	1995;6:477	NUM
fnp-3806	3615	3	-	-	PUNCT
fnp-3806	3615	4	480	480	NUM
fnp-3806	3615	5	.	.	PUNCT
fnp-3806	3616	1	https://doi.org/10.1097/00001756-199502000-00018	https://doi.org/10.1097/00001756-199502000-00018	PROPN
fnp-3806	3616	2	wu	wu	PROPN
fnp-3806	3616	3	z	z	PROPN
fnp-3806	3616	4	,	,	PUNCT
fnp-3806	3616	5	guo	guo	PROPN
fnp-3806	3616	6	h	h	PROPN
fnp-3806	3616	7	,	,	PUNCT
fnp-3806	3616	8	chow	chow	PROPN
fnp-3806	3616	9	n	n	CCONJ
fnp-3806	3616	10	,	,	PUNCT
fnp-3806	3616	11	sallstrom	sallstrom	PROPN
fnp-3806	3616	12	j	j	PROPN
fnp-3806	3616	13	,	,	PUNCT
fnp-3806	3616	14	et	et	PROPN
fnp-3806	3616	15	al	al	PROPN
fnp-3806	3616	16	.	.	PUNCT
fnp-3806	3617	1	role	role	NOUN
fnp-3806	3617	2	of	of	ADP
fnp-3806	3617	3	the	the	DET
fnp-3806	3617	4	meox2	meox2	PROPN
fnp-3806	3617	5	homeobox	homeobox	PROPN
fnp-3806	3617	6	gene	gene	NOUN
fnp-3806	3617	7	in	in	ADP
fnp-3806	3617	8	neurovascular	neurovascular	ADJ
fnp-3806	3617	9	dysfunction	dysfunction	NOUN
fnp-3806	3617	10	in	in	ADP
fnp-3806	3617	11	alzheimer	alzheimer	PROPN
fnp-3806	3617	12	disease	disease	PROPN
fnp-3806	3617	13	.	.	PUNCT
fnp-3806	3618	1	nat	nat	PROPN
fnp-3806	3618	2	med	me	VERB
fnp-3806	3618	3	2005;11:959	2005;11:959	NOUN
fnp-3806	3618	4	-	-	SYM
fnp-3806	3618	5	965	965	NUM
fnp-3806	3618	6	.	.	PUNCT
fnp-3806	3619	1	https://doi.org/10.1038/nm1287	https://doi.org/10.1038/nm1287	X
fnp-3806	3619	2	hashimura	hashimura	PROPN
fnp-3806	3619	3	t	t	PROPN
fnp-3806	3619	4	,	,	PUNCT
fnp-3806	3619	5	kimura	kimura	PROPN
fnp-3806	3619	6	t	t	PROPN
fnp-3806	3619	7	,	,	PUNCT
fnp-3806	3619	8	miyakawa	miyakawa	PROPN
fnp-3806	3619	9	t.	t.	NOUN
fnp-3806	3619	10	morphological	morphological	ADJ
fnp-3806	3619	11	changes	change	NOUN
fnp-3806	3619	12	of	of	ADP
fnp-3806	3619	13	blood	blood	NOUN
fnp-3806	3619	14	vessels	vessel	NOUN
fnp-3806	3619	15	in	in	ADP
fnp-3806	3619	16	the	the	DET
fnp-3806	3619	17	brain	brain	NOUN
fnp-3806	3619	18	with	with	ADP
fnp-3806	3619	19	alzheimer	alzheimer	PROPN
fnp-3806	3619	20	’s	’s	PART
fnp-3806	3619	21	disease	disease	NOUN
fnp-3806	3619	22	.	.	PUNCT
fnp-3806	3620	1	jpn	jpn	PROPN
fnp-3806	3620	2	j	j	PROPN
fnp-3806	3620	3	psychiatry	psychiatry	PROPN
fnp-3806	3620	4	neurol	neurol	PROPN
fnp-3806	3620	5	1991;45:661	1991;45:661	ADV
fnp-3806	3620	6	-	-	SYM
fnp-3806	3620	7	665	665	NUM
fnp-3806	3620	8	.	.	PUNCT
fnp-3806	3621	1	https://doi.org/10.1111/j.1440-1819.1991.tb01187.x	https://doi.org/10.1111/j.1440-1819.1991.tb01187.x	PROPN
fnp-3806	3621	2	sagare	sagare	PROPN
fnp-3806	3621	3	ap	ap	PROPN
fnp-3806	3621	4	,	,	PUNCT
fnp-3806	3621	5	bell	bell	PROPN
fnp-3806	3621	6	rd	rd	PROPN
fnp-3806	3621	7	,	,	PUNCT
fnp-3806	3621	8	zlokovic	zlokovic	PROPN
fnp-3806	3621	9	bv	bv	PROPN
fnp-3806	3621	10	.	.	PROPN
fnp-3806	3621	11	neurovascular	neurovascular	ADJ
fnp-3806	3621	12	defects	defect	NOUN
fnp-3806	3621	13	and	and	CCONJ
fnp-3806	3621	14	faulty	faulty	ADJ
fnp-3806	3621	15	amyloid	amyloid	NOUN
fnp-3806	3621	16	-	-	PUNCT
fnp-3806	3621	17	beta	beta	ADJ
fnp-3806	3621	18	vascular	vascular	ADJ
fnp-3806	3621	19	clearance	clearance	NOUN
fnp-3806	3621	20	in	in	ADP
fnp-3806	3621	21	alzheimer	alzheimer	PROPN
fnp-3806	3621	22	's	's	PART
fnp-3806	3621	23	disease	disease	NOUN
fnp-3806	3621	24	.	.	PUNCT
fnp-3806	3622	1	j	j	PROPN
fnp-3806	3622	2	alzheimers	alzheimers	PROPN
fnp-3806	3622	3	dis	dis	PROPN
fnp-3806	3622	4	2013;33	2013;33	NUM
fnp-3806	3622	5	:	:	PUNCT
fnp-3806	3622	6	s87	s87	NOUN
fnp-3806	3622	7	-	-	SYM
fnp-3806	3622	8	100	100	NUM
fnp-3806	3622	9	.	.	PUNCT
fnp-3806	3623	1	https://doi.org/10.3233/jad-2012-129037	https://doi.org/10.3233/jad-2012-129037	PROPN
fnp-3806	3623	2	ma	ma	PROPN
fnp-3806	3623	3	q	q	PROPN
fnp-3806	3623	4	,	,	PUNCT
fnp-3806	3623	5	zhao	zhao	PROPN
fnp-3806	3623	6	z	z	PROPN
fnp-3806	3623	7	,	,	PUNCT
fnp-3806	3623	8	sagare	sagare	PROPN
fnp-3806	3623	9	ap	ap	PROPN
fnp-3806	3623	10	,	,	PUNCT
fnp-3806	3623	11	et	et	PROPN
fnp-3806	3623	12	al	al	PROPN
fnp-3806	3623	13	.	.	PUNCT
fnp-3806	3623	14	blood	blood	NOUN
fnp-3806	3623	15	-	-	PUNCT
fnp-3806	3623	16	brain	brain	NOUN
fnp-3806	3623	17	barrier	barrier	NOUN
fnp-3806	3623	18	-	-	PUNCT
fnp-3806	3623	19	associated	associate	VERB
fnp-3806	3623	20	pericytes	pericyte	NOUN
fnp-3806	3623	21	internalize	internalize	VERB
fnp-3806	3623	22	and	and	CCONJ
fnp-3806	3623	23	clear	clear	ADJ
fnp-3806	3623	24	aggregated	aggregate	VERB
fnp-3806	3623	25	amyloid	amyloid	NOUN
fnp-3806	3623	26	-	-	PUNCT
fnp-3806	3623	27	beta42	beta42	NOUN
fnp-3806	3623	28	by	by	ADP
fnp-3806	3623	29	lrp1	lrp1	NOUN
fnp-3806	3623	30	-	-	PUNCT
fnp-3806	3623	31	dependent	dependent	ADJ
fnp-3806	3623	32	apolipoprotein	apolipoprotein	ADJ
fnp-3806	3623	33	e	e	VERB
fnp-3806	3623	34	isoform	isoform	NOUN
fnp-3806	3623	35	-	-	PUNCT
fnp-3806	3623	36	specific	specific	ADJ
fnp-3806	3623	37	mechanism	mechanism	NOUN
fnp-3806	3623	38	.	.	PUNCT
fnp-3806	3624	1	mol	mol	ADP
fnp-3806	3624	2	neurodegener	neurodegener	NOUN
fnp-3806	3624	3	2018;13:57	2018;13:57	NUM
fnp-3806	3624	4	.	.	PUNCT
fnp-3806	3625	1	https://doi.org/10.1186/s13024-018-0286-0	https://doi.org/10.1186/s13024-018-0286-0	NUM
fnp-3806	3625	2	lendahl	lendahl	PROPN
fnp-3806	3625	3	u	u	PROPN
fnp-3806	3625	4	,	,	PUNCT
fnp-3806	3625	5	nilsson	nilsson	PROPN
fnp-3806	3625	6	p	p	PROPN
fnp-3806	3625	7	,	,	PUNCT
fnp-3806	3625	8	betsholtz	betsholtz	PROPN
fnp-3806	3625	9	c.	c.	NOUN
fnp-3806	3625	10	emerging	emerge	VERB
fnp-3806	3625	11	links	link	NOUN
fnp-3806	3625	12	between	between	ADP
fnp-3806	3625	13	cerebrovascular	cerebrovascular	ADJ
fnp-3806	3625	14	and	and	CCONJ
fnp-3806	3625	15	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3625	16	diseases	disease	NOUN
fnp-3806	3625	17	-	-	PUNCT
fnp-3806	3625	18	a	a	DET
fnp-3806	3625	19	special	special	ADJ
fnp-3806	3625	20	role	role	NOUN
fnp-3806	3625	21	for	for	ADP
fnp-3806	3625	22	pericytes	pericyte	NOUN
fnp-3806	3625	23	.	.	PUNCT
fnp-3806	3626	1	embo	embo	PROPN
fnp-3806	3626	2	rep	rep	PROPN
fnp-3806	3626	3	2019;20	2019;20	PROPN
fnp-3806	3626	4	:	:	PUNCT
fnp-3806	3626	5	e48070	e48070	PROPN
fnp-3806	3626	6	.	.	PROPN
fnp-3806	3626	7	https://doi.org/10.15252/embr.201948070	https://doi.org/10.15252/embr.201948070	VERB
fnp-3806	3626	8	nortley	nortley	PROPN
fnp-3806	3626	9	r	r	PROPN
fnp-3806	3626	10	,	,	PUNCT
fnp-3806	3626	11	korte	korte	PROPN
fnp-3806	3626	12	n	n	CCONJ
fnp-3806	3626	13	,	,	PUNCT
fnp-3806	3626	14	izquierdo	izquierdo	PROPN
fnp-3806	3626	15	p	p	NOUN
fnp-3806	3626	16	,	,	PUNCT
fnp-3806	3626	17	et	et	PROPN
fnp-3806	3626	18	al	al	PROPN
fnp-3806	3626	19	.	.	PUNCT
fnp-3806	3627	1	β	β	PROPN
fnp-3806	3627	2	oligomers	oligomer	NOUN
fnp-3806	3627	3	constrict	constrict	VERB
fnp-3806	3627	4	human	human	ADJ
fnp-3806	3627	5	capillaries	capillary	NOUN
fnp-3806	3627	6	in	in	ADP
fnp-3806	3627	7	alzheimer	alzheimer	PROPN
fnp-3806	3627	8	's	's	PART
fnp-3806	3627	9	disease	disease	NOUN
fnp-3806	3627	10	via	via	ADP
fnp-3806	3627	11	signaling	signal	VERB
fnp-3806	3627	12	to	to	ADP
fnp-3806	3627	13	pericytes	pericyte	NOUN
fnp-3806	3627	14	.	.	PUNCT
fnp-3806	3628	1	science	science	NOUN
fnp-3806	3628	2	2019;365	2019;365	NUM
fnp-3806	3628	3	:	:	PUNCT
fnp-3806	3629	1	eaav9518	eaav9518	NOUN
fnp-3806	3629	2	.	.	PUNCT
fnp-3806	3630	1	https://doi.org/10.1126/science.aav9518	https://doi.org/10.1126/science.aav9518	PROPN
fnp-3806	3630	2	winkler	winkler	PROPN
fnp-3806	3630	3	ea	ea	PROPN
fnp-3806	3630	4	,	,	PUNCT
fnp-3806	3630	5	sengillo	sengillo	PROPN
fnp-3806	3630	6	jd	jd	PROPN
fnp-3806	3630	7	,	,	PUNCT
fnp-3806	3630	8	bell	bell	PROPN
fnp-3806	3630	9	rd	rd	PROPN
fnp-3806	3630	10	,	,	PUNCT
fnp-3806	3630	11	et	et	PROPN
fnp-3806	3630	12	al	al	PROPN
fnp-3806	3630	13	.	.	PUNCT
fnp-3806	3630	14	blood	blood	NOUN
fnp-3806	3630	15	-	-	PUNCT
fnp-3806	3630	16	spinal	spinal	NOUN
fnp-3806	3630	17	cord	cord	NOUN
fnp-3806	3630	18	barrier	barrier	NOUN
fnp-3806	3630	19	pericyte	pericyte	NOUN
fnp-3806	3630	20	reductions	reduction	NOUN
fnp-3806	3630	21	contribute	contribute	VERB
fnp-3806	3630	22	to	to	ADP
fnp-3806	3630	23	increased	increase	VERB
fnp-3806	3630	24	capillary	capillary	ADJ
fnp-3806	3630	25	permeability	permeability	NOUN
fnp-3806	3630	26	.	.	PUNCT
fnp-3806	3631	1	j	j	PROPN
fnp-3806	3631	2	cereb	cereb	PROPN
fnp-3806	3631	3	blood	blood	NOUN
fnp-3806	3631	4	flow	flow	NOUN
fnp-3806	3631	5	metab	metab	NOUN
fnp-3806	3631	6	2012;32:1841	2012;32:1841	NUM
fnp-3806	3631	7	-	-	SYM
fnp-3806	3631	8	1852	1852	NUM
fnp-3806	3631	9	.	.	PUNCT
fnp-3806	3632	1	https://doi.org/10.1038/jcbfm.2012.113	https://doi.org/10.1038/jcbfm.2012.113	ADJ
fnp-3806	3632	2	winkler	winkler	PROPN
fnp-3806	3632	3	ea	ea	PROPN
fnp-3806	3632	4	,	,	PUNCT
fnp-3806	3632	5	sagare	sagare	PROPN
fnp-3806	3632	6	ap	ap	PROPN
fnp-3806	3632	7	,	,	PUNCT
fnp-3806	3632	8	zlokovic	zlokovic	PROPN
fnp-3806	3632	9	bv	bv	PROPN
fnp-3806	3632	10	.	.	PROPN
fnp-3806	3633	1	the	the	DET
fnp-3806	3633	2	pericyte	pericyte	NOUN
fnp-3806	3633	3	:	:	PUNCT
fnp-3806	3633	4	a	a	DET
fnp-3806	3633	5	forgotten	forget	VERB
fnp-3806	3633	6	cell	cell	NOUN
fnp-3806	3633	7	type	type	NOUN
fnp-3806	3633	8	with	with	ADP
fnp-3806	3633	9	important	important	ADJ
fnp-3806	3633	10	implications	implication	NOUN
fnp-3806	3633	11	for	for	ADP
fnp-3806	3633	12	alzheimer	alzheimer	PROPN
fnp-3806	3633	13	’s	’s	PART
fnp-3806	3633	14	disease	disease	NOUN
fnp-3806	3633	15	?	?	PUNCT
fnp-3806	3634	1	brain	brain	NOUN
fnp-3806	3634	2	pathol	pathol	NOUN
fnp-3806	3634	3	2014;24:371	2014;24:371	NOUN
fnp-3806	3634	4	-	-	SYM
fnp-3806	3634	5	386	386	NUM
fnp-3806	3634	6	.	.	PUNCT
fnp-3806	3635	1	https://doi.org/10.1111/bpa.12152	https://doi.org/10.1111/bpa.12152	PROPN
fnp-3806	3635	2	kalback	kalback	VERB
fnp-3806	3635	3	w	w	PROPN
fnp-3806	3635	4	,	,	PUNCT
fnp-3806	3635	5	esh	esh	PROPN
fnp-3806	3635	6	c	c	NOUN
fnp-3806	3635	7	,	,	PUNCT
fnp-3806	3635	8	castano	castano	VERB
fnp-3806	3635	9	em	em	PRON
fnp-3806	3635	10	,	,	PUNCT
fnp-3806	3635	11	et	et	PROPN
fnp-3806	3635	12	al	al	PROPN
fnp-3806	3635	13	.	.	PUNCT
fnp-3806	3635	14	atherosclerosis	atherosclerosis	NOUN
fnp-3806	3635	15	,	,	PUNCT
fnp-3806	3635	16	vascular	vascular	ADJ
fnp-3806	3635	17	amyloidosis	amyloidosis	NOUN
fnp-3806	3635	18	and	and	CCONJ
fnp-3806	3635	19	brain	brain	NOUN
fnp-3806	3635	20	hypoperfusion	hypoperfusion	NOUN
fnp-3806	3635	21	in	in	ADP
fnp-3806	3635	22	the	the	DET
fnp-3806	3635	23	pathogenesis	pathogenesis	NOUN
fnp-3806	3635	24	of	of	ADP
fnp-3806	3635	25	sporadic	sporadic	ADJ
fnp-3806	3635	26	alzheimer	alzheimer	PROPN
fnp-3806	3635	27	's	's	PART
fnp-3806	3635	28	disease	disease	NOUN
fnp-3806	3635	29	.	.	PUNCT
fnp-3806	3636	1	neurol	neurol	NOUN
fnp-3806	3636	2	res	re	VERB
fnp-3806	3636	3	2004;26:525	2004;26:525	NOUN
fnp-3806	3636	4	-	-	SYM
fnp-3806	3636	5	539	539	NUM
fnp-3806	3636	6	.	.	PUNCT
fnp-3806	3637	1	https://doi.org/10.1179/016164104225017668	https://doi.org/10.1179/016164104225017668	NOUN
fnp-3806	3638	1	shabir	shabir	PROPN
fnp-3806	3638	2	o	o	PROPN
fnp-3806	3638	3	,	,	PUNCT
fnp-3806	3638	4	berwick	berwick	PROPN
fnp-3806	3638	5	j	j	PROPN
fnp-3806	3638	6	,	,	PUNCT
fnp-3806	3638	7	francis	francis	PROPN
fnp-3806	3638	8	se	se	PROPN
fnp-3806	3638	9	.	.	PUNCT
fnp-3806	3639	1	neurovascular	neurovascular	ADJ
fnp-3806	3639	2	dysfunction	dysfunction	NOUN
fnp-3806	3639	3	in	in	ADP
fnp-3806	3639	4	vascular	vascular	ADJ
fnp-3806	3639	5	dementia	dementia	NOUN
fnp-3806	3639	6	,	,	PUNCT
fnp-3806	3639	7	alzheimer	alzheimer	PROPN
fnp-3806	3639	8	's	's	PART
fnp-3806	3639	9	and	and	CCONJ
fnp-3806	3639	10	atherosclerosis	atherosclerosis	NOUN
fnp-3806	3639	11	.	.	PUNCT
fnp-3806	3640	1	bmc	bmc	PROPN
fnp-3806	3640	2	neurosci	neurosci	PROPN
fnp-3806	3640	3	2018;19:62	2018;19:62	NUM
fnp-3806	3640	4	.	.	PUNCT
fnp-3806	3641	1	https://doi.org/10.1186/s12868-018-0465-5	https://doi.org/10.1186/s12868-018-0465-5	NUM
fnp-3806	3641	2	bell	bell	PROPN
fnp-3806	3641	3	rd	rd	PROPN
fnp-3806	3641	4	,	,	PUNCT
fnp-3806	3641	5	winkler	winkler	PROPN
fnp-3806	3641	6	ea	ea	PROPN
fnp-3806	3641	7	,	,	PUNCT
fnp-3806	3641	8	singh	singh	PROPN
fnp-3806	3641	9	i	i	PROPN
fnp-3806	3641	10	,	,	PUNCT
fnp-3806	3641	11	et	et	PROPN
fnp-3806	3641	12	al	al	PROPN
fnp-3806	3641	13	.	.	PROPN
fnp-3806	3642	1	apolipoprotein	apolipoprotein	PROPN
fnp-3806	3642	2	e	e	PROPN
fnp-3806	3642	3	controls	control	VERB
fnp-3806	3642	4	cerebrovascular	cerebrovascular	ADJ
fnp-3806	3642	5	integrity	integrity	NOUN
fnp-3806	3642	6	via	via	ADP
fnp-3806	3642	7	cyclophilin	cyclophilin	PROPN
fnp-3806	3642	8	a.	a.	PROPN
fnp-3806	3642	9	nature	nature	PROPN
fnp-3806	3642	10	2012;485:512	2012;485:512	NUM
fnp-3806	3642	11	-	-	SYM
fnp-3806	3642	12	516	516	NUM
fnp-3806	3642	13	.	.	PUNCT
fnp-3806	3643	1	https://doi.org/10.1038/nature11087	https://doi.org/10.1038/nature11087	PROPN
fnp-3806	3643	2	mosconi	mosconi	PROPN
fnp-3806	3643	3	l	l	PROPN
fnp-3806	3643	4	,	,	PUNCT
fnp-3806	3643	5	sorbi	sorbi	PROPN
fnp-3806	3643	6	s	s	PART
fnp-3806	3643	7	,	,	PUNCT
fnp-3806	3643	8	de	de	PROPN
fnp-3806	3643	9	leon	leon	PROPN
fnp-3806	3643	10	mj	mj	PROPN
fnp-3806	3643	11	,	,	PUNCT
fnp-3806	3643	12	et	et	PROPN
fnp-3806	3643	13	al	al	PROPN
fnp-3806	3643	14	.	.	PUNCT
fnp-3806	3643	15	hypometabolism	hypometabolism	PROPN
fnp-3806	3643	16	exceeds	exceed	VERB
fnp-3806	3643	17	atrophy	atrophy	NOUN
fnp-3806	3643	18	in	in	ADP
fnp-3806	3643	19	presymptomatic	presymptomatic	ADJ
fnp-3806	3643	20	early	early	ADJ
fnp-3806	3643	21	-	-	PUNCT
fnp-3806	3643	22	onset	onset	NOUN
fnp-3806	3643	23	familial	familial	ADJ
fnp-3806	3643	24	alzheimer	alzheimer	PROPN
fnp-3806	3643	25	’s	’s	PART
fnp-3806	3643	26	disease	disease	NOUN
fnp-3806	3643	27	.	.	PUNCT
fnp-3806	3644	1	j	j	PROPN
fnp-3806	3644	2	nucl	nucl	PROPN
fnp-3806	3644	3	med	me	VERB
fnp-3806	3644	4	2006;47:1778–1786	2006;47:1778–1786	PROPN
fnp-3806	3644	5	.	.	PUNCT
fnp-3806	3645	1	pmid	pmid	NOUN
fnp-3806	3645	2	:	:	PUNCT
fnp-3806	3645	3	17079810	17079810	NUM
fnp-3806	3645	4	.	.	PUNCT
fnp-3806	3646	1	nation	nation	PROPN
fnp-3806	3646	2	da	da	PROPN
fnp-3806	3646	3	,	,	PUNCT
fnp-3806	3646	4	sweeney	sweeney	PROPN
fnp-3806	3646	5	md	md	PROPN
fnp-3806	3646	6	,	,	PUNCT
fnp-3806	3646	7	montagne	montagne	PROPN
fnp-3806	3646	8	a	a	PROPN
fnp-3806	3646	9	,	,	PUNCT
fnp-3806	3646	10	et	et	PROPN
fnp-3806	3646	11	al	al	PROPN
fnp-3806	3646	12	.	.	PUNCT
fnp-3806	3646	13	blood	blood	NOUN
fnp-3806	3646	14	-	-	PUNCT
fnp-3806	3646	15	brain	brain	NOUN
fnp-3806	3646	16	barrier	barrier	NOUN
fnp-3806	3646	17	breakdown	breakdown	NOUN
fnp-3806	3646	18	is	be	AUX
fnp-3806	3646	19	an	an	DET
fnp-3806	3646	20	early	early	ADJ
fnp-3806	3646	21	biomarker	biomarker	NOUN
fnp-3806	3646	22	of	of	ADP
fnp-3806	3646	23	human	human	ADJ
fnp-3806	3646	24	cognitive	cognitive	ADJ
fnp-3806	3646	25	dysfunction	dysfunction	NOUN
fnp-3806	3646	26	.	.	PUNCT
fnp-3806	3647	1	nat	nat	PROPN
fnp-3806	3647	2	med	me	VERB
fnp-3806	3647	3	2019	2019	NUM
fnp-3806	3647	4	;	;	PUNCT
fnp-3806	3647	5	25	25	NUM
fnp-3806	3647	6	:	:	SYM
fnp-3806	3647	7	270	270	NUM
fnp-3806	3647	8	-	-	SYM
fnp-3806	3647	9	276	276	NUM
fnp-3806	3647	10	.	.	PUNCT
fnp-3806	3648	1	https://doi.org/10.1038/s41591-018-0297-y	https://doi.org/10.1038/s41591-018-0297-y	PROPN
fnp-3806	3648	2	winkler	winkler	PROPN
fnp-3806	3648	3	ea	ea	PROPN
fnp-3806	3648	4	,	,	PUNCT
fnp-3806	3648	5	nishida	nishida	PROPN
fnp-3806	3648	6	y	y	PROPN
fnp-3806	3648	7	,	,	PUNCT
fnp-3806	3648	8	sagare	sagare	PROPN
fnp-3806	3648	9	ap	ap	PROPN
fnp-3806	3648	10	,	,	PUNCT
fnp-3806	3648	11	et	et	PROPN
fnp-3806	3648	12	al	al	PROPN
fnp-3806	3648	13	.	.	PUNCT
fnp-3806	3648	14	glut1	glut1	VERB
fnp-3806	3648	15	reductions	reduction	NOUN
fnp-3806	3648	16	exacerbate	exacerbate	VERB
fnp-3806	3648	17	alzheimer	alzheimer	PROPN
fnp-3806	3648	18	's	's	PART
fnp-3806	3648	19	disease	disease	NOUN
fnp-3806	3648	20	vasculo	vasculo	NOUN
fnp-3806	3648	21	-	-	PUNCT
fnp-3806	3648	22	neuronal	neuronal	ADJ
fnp-3806	3648	23	dysfunction	dysfunction	NOUN
fnp-3806	3648	24	and	and	CCONJ
fnp-3806	3648	25	degeneration	degeneration	NOUN
fnp-3806	3648	26	.	.	PUNCT
fnp-3806	3649	1	nat	nat	PROPN
fnp-3806	3649	2	neurosci	neurosci	PROPN
fnp-3806	3649	3	2015;18:521	2015;18:521	PROPN
fnp-3806	3649	4	-	-	SYM
fnp-3806	3649	5	530	530	NUM
fnp-3806	3649	6	.	.	PUNCT
fnp-3806	3650	1	https://doi.org/10.1038/nn.3966	https://doi.org/10.1038/nn.3966	VERB
fnp-3806	3650	2	koepsell	koepsell	PROPN
fnp-3806	3650	3	h.	h.	NOUN
fnp-3806	3650	4	glucose	glucose	NOUN
fnp-3806	3650	5	transporters	transporter	NOUN
fnp-3806	3650	6	in	in	ADP
fnp-3806	3650	7	brain	brain	NOUN
fnp-3806	3650	8	in	in	ADP
fnp-3806	3650	9	health	health	NOUN
fnp-3806	3650	10	and	and	CCONJ
fnp-3806	3650	11	disease	disease	NOUN
fnp-3806	3650	12	.	.	PUNCT
fnp-3806	3651	1	pflugers	pfluger	NOUN
fnp-3806	3651	2	arch	arch	VERB
fnp-3806	3651	3	2020;472:1299	2020;472:1299	NUM
fnp-3806	3651	4	-	-	SYM
fnp-3806	3651	5	1343	1343	NUM
fnp-3806	3651	6	.	.	PUNCT
fnp-3806	3652	1	https://doi.org/10.1007/s00424-020-02441-x	https://doi.org/10.1007/s00424-020-02441-x	NOUN
fnp-3806	3652	2	an	an	DET
fnp-3806	3652	3	y	y	PROPN
fnp-3806	3652	4	,	,	PUNCT
fnp-3806	3652	5	varma	varma	PROPN
fnp-3806	3652	6	vr	vr	PROPN
fnp-3806	3652	7	,	,	PUNCT
fnp-3806	3652	8	varma	varma	PROPN
fnp-3806	3652	9	s	s	PROPN
fnp-3806	3652	10	,	,	PUNCT
fnp-3806	3652	11	et	et	PROPN
fnp-3806	3652	12	al	al	PROPN
fnp-3806	3652	13	.	.	PROPN
fnp-3806	3652	14	evidence	evidence	NOUN
fnp-3806	3652	15	for	for	ADP
fnp-3806	3652	16	brain	brain	NOUN
fnp-3806	3652	17	glucose	glucose	NOUN
fnp-3806	3652	18	dysregulation	dysregulation	NOUN
fnp-3806	3652	19	in	in	ADP
fnp-3806	3652	20	alzheimer	alzheimer	PROPN
fnp-3806	3652	21	's	's	PART
fnp-3806	3652	22	disease	disease	NOUN
fnp-3806	3652	23	.	.	PUNCT
fnp-3806	3653	1	alzheimers	alzheimers	PROPN
fnp-3806	3653	2	dement	dement	PROPN
fnp-3806	3653	3	2018;14:318	2018;14:318	PROPN
fnp-3806	3653	4	-	-	SYM
fnp-3806	3653	5	329	329	NUM
fnp-3806	3653	6	.	.	PUNCT
fnp-3806	3654	1	https://doi.org/10.1016/j.jalz.2017.09.011	https://doi.org/10.1016/j.jalz.2017.09.011	VERB
fnp-3806	3654	2	szu	szu	PROPN
fnp-3806	3654	3	ji	ji	PROPN
fnp-3806	3654	4	,	,	PUNCT
fnp-3806	3654	5	obenaus	obenaus	X
fnp-3806	3654	6	a	a	PRON
fnp-3806	3654	7	..	..	PUNCT
fnp-3806	3654	8	cerebrovascular	cerebrovascular	ADJ
fnp-3806	3654	9	phenotypes	phenotype	NOUN
fnp-3806	3654	10	in	in	ADP
fnp-3806	3654	11	mouse	mouse	NOUN
fnp-3806	3654	12	models	model	NOUN
fnp-3806	3654	13	of	of	ADP
fnp-3806	3654	14	alzheimer	alzheimer	PROPN
fnp-3806	3654	15	's	's	PART
fnp-3806	3654	16	disease	disease	NOUN
fnp-3806	3654	17	.	.	PUNCT
fnp-3806	3655	1	cereb	cereb	PROPN
fnp-3806	3655	2	blood	blood	NOUN
fnp-3806	3655	3	flow	flow	NOUN
fnp-3806	3655	4	metab	metab	ADJ
fnp-3806	3655	5	2021;41:1821	2021;41:1821	NUM
fnp-3806	3655	6	-	-	SYM
fnp-3806	3655	7	1841	1841	NUM
fnp-3806	3655	8	.	.	PUNCT
fnp-3806	3656	1	https://doi.org/10.1177/0271678x21992462	https://doi.org/10.1177/0271678x21992462	PROPN
fnp-3806	3656	2	canepa	canepa	PROPN
fnp-3806	3656	3	e	e	NOUN
fnp-3806	3656	4	,	,	PUNCT
fnp-3806	3656	5	fossati	fossati	PROPN
fnp-3806	3656	6	s.	s.	PROPN
fnp-3806	3656	7	impact	impact	PROPN
fnp-3806	3656	8	of	of	ADP
fnp-3806	3656	9	tau	tau	PROPN
fnp-3806	3656	10	on	on	ADP
fnp-3806	3656	11	neurovascular	neurovascular	ADJ
fnp-3806	3656	12	pathology	pathology	NOUN
fnp-3806	3656	13	in	in	ADP
fnp-3806	3656	14	alzheimer	alzheimer	PROPN
fnp-3806	3656	15	's	's	PART
fnp-3806	3656	16	disease	disease	NOUN
fnp-3806	3656	17	.	.	PUNCT
fnp-3806	3657	1	front	front	ADJ
fnp-3806	3657	2	neurol	neurol	NOUN
fnp-3806	3657	3	2021;11:573324	2021;11:573324	NUM
fnp-3806	3657	4	.	.	PUNCT
fnp-3806	3658	1	https://doi.org/10.3389/fneur.2020.573324	https://doi.org/10.3389/fneur.2020.573324	PROPN
fnp-3806	3658	2	blair	blair	PROPN
fnp-3806	3658	3	lj	lj	PROPN
fnp-3806	3658	4	,	,	PUNCT
fnp-3806	3658	5	frauen	frauen	PROPN
fnp-3806	3658	6	hd	hd	PROPN
fnp-3806	3658	7	,	,	PUNCT
fnp-3806	3658	8	zhang	zhang	PROPN
fnp-3806	3658	9	b	b	PROPN
fnp-3806	3658	10	,	,	PUNCT
fnp-3806	3658	11	et	et	PROPN
fnp-3806	3658	12	al	al	PROPN
fnp-3806	3658	13	.	.	PUNCT
fnp-3806	3659	1	tau	tau	PROPN
fnp-3806	3659	2	depletion	depletion	NOUN
fnp-3806	3659	3	prevents	prevent	VERB
fnp-3806	3659	4	progressive	progressive	ADJ
fnp-3806	3659	5	blood	blood	NOUN
fnp-3806	3659	6	-	-	PUNCT
fnp-3806	3659	7	brain	brain	NOUN
fnp-3806	3659	8	barrier	barrier	NOUN
fnp-3806	3659	9	damage	damage	NOUN
fnp-3806	3659	10	in	in	ADP
fnp-3806	3659	11	a	a	DET
fnp-3806	3659	12	mouse	mouse	NOUN
fnp-3806	3659	13	model	model	NOUN
fnp-3806	3659	14	of	of	ADP
fnp-3806	3659	15	tauopathy	tauopathy	NOUN
fnp-3806	3659	16	.	.	PUNCT
fnp-3806	3660	1	acta	acta	PROPN
fnp-3806	3660	2	neuropathol	neuropathol	PROPN
fnp-3806	3660	3	commun	commun	PROPN
fnp-3806	3660	4	2015;3:8	2015;3:8	PROPN
fnp-3806	3660	5	.	.	PUNCT
fnp-3806	3661	1	https://doi.org/10.1186/s40478-015-0186-2	https://doi.org/10.1186/s40478-015-0186-2	X
fnp-3806	3662	1	love	love	PROPN
fnp-3806	3662	2	s	s	PROPN
fnp-3806	3662	3	,	,	PUNCT
fnp-3806	3662	4	miners	miner	NOUN
fnp-3806	3662	5	j.	j.	PROPN
fnp-3806	3662	6	cerebrovascular	cerebrovascular	ADJ
fnp-3806	3662	7	disease	disease	NOUN
fnp-3806	3662	8	in	in	ADP
fnp-3806	3662	9	ageing	age	VERB
fnp-3806	3662	10	and	and	CCONJ
fnp-3806	3662	11	alzheimer	alzheimer	NOUN
fnp-3806	3662	12	's	's	PART
fnp-3806	3662	13	disease	disease	NOUN
fnp-3806	3662	14	acta	acta	PROPN
fnp-3806	3662	15	neuropathol	neuropathol	PROPN
fnp-3806	3662	16	2016;131:645	2016;131:645	PROPN
fnp-3806	3662	17	-	-	SYM
fnp-3806	3662	18	658	658	NUM
fnp-3806	3662	19	.	.	PUNCT
fnp-3806	3663	1	https://doi.org/10.1007/s00401-015-1522-0	https://doi.org/10.1007/s00401-015-1522-0	NUM
fnp-3806	3663	2	yu	yu	PROPN
fnp-3806	3663	3	x	x	PROPN
fnp-3806	3663	4	,	,	PUNCT
fnp-3806	3663	5	ji	ji	PROPN
fnp-3806	3663	6	c	c	PROPN
fnp-3806	3663	7	,	,	PUNCT
fnp-3806	3663	8	shao	shao	PROPN
fnp-3806	3663	9	a.	a.	PROPN
fnp-3806	3663	10	neurovascular	neurovascular	PROPN
fnp-3806	3663	11	unit	unit	NOUN
fnp-3806	3663	12	dysfunction	dysfunction	NOUN
fnp-3806	3663	13	and	and	CCONJ
fnp-3806	3663	14	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3663	15	disorders	disorder	NOUN
fnp-3806	3663	16	.	.	PUNCT
fnp-3806	3664	1	front	front	ADJ
fnp-3806	3664	2	neurosci	neurosci	NOUN
fnp-3806	3664	3	2020;14:334	2020;14:334	X
fnp-3806	3664	4	.	.	PUNCT
fnp-3806	3665	1	https://doi.org/10.3389/fnins.2020.00334	https://doi.org/10.3389/fnins.2020.00334	PROPN
fnp-3806	3665	2	gordon	gordon	PROPN
fnp-3806	3665	3	gr	gr	PROPN
fnp-3806	3665	4	,	,	PUNCT
fnp-3806	3665	5	choi	choi	PROPN
fnp-3806	3665	6	hb	hb	PROPN
fnp-3806	3665	7	,	,	PUNCT
fnp-3806	3665	8	rungta	rungta	PROPN
fnp-3806	3665	9	rl	rl	X
fnp-3806	3665	10	,	,	PUNCT
fnp-3806	3665	11	et	et	PROPN
fnp-3806	3665	12	al	al	PROPN
fnp-3806	3665	13	.	.	PROPN
fnp-3806	3666	1	brain	brain	NOUN
fnp-3806	3666	2	metabolism	metabolism	NOUN
fnp-3806	3666	3	dictates	dictate	VERB
fnp-3806	3666	4	the	the	DET
fnp-3806	3666	5	polarity	polarity	NOUN
fnp-3806	3666	6	of	of	ADP
fnp-3806	3666	7	astrocyte	astrocyte	NOUN
fnp-3806	3666	8	control	control	NOUN
fnp-3806	3666	9	over	over	ADP
fnp-3806	3666	10	arterioles	arterioles	PROPN
fnp-3806	3666	11	.	.	PUNCT
fnp-3806	3667	1	nature	nature	NOUN
fnp-3806	3667	2	2008	2008	NUM
fnp-3806	3667	3	;	;	PUNCT
fnp-3806	3667	4	456	456	NUM
fnp-3806	3667	5	:	:	PUNCT
fnp-3806	3667	6	745	745	NUM
fnp-3806	3667	7	-	-	SYM
fnp-3806	3667	8	749	749	NUM
fnp-3806	3667	9	.	.	PUNCT
fnp-3806	3668	1	https://doi.org/10.1038/nature07525	https://doi.org/10.1038/nature07525	PROPN
fnp-3806	3668	2	ipata	ipata	PROPN
fnp-3806	3668	3	pl	pl	PROPN
fnp-3806	3668	4	,	,	PUNCT
fnp-3806	3668	5	camici	camici	NOUN
fnp-3806	3668	6	m	m	PROPN
fnp-3806	3668	7	,	,	PUNCT
fnp-3806	3668	8	micheli	micheli	PROPN
fnp-3806	3668	9	v	v	PROPN
fnp-3806	3668	10	,	,	PUNCT
fnp-3806	3668	11	et	et	PROPN
fnp-3806	3668	12	al	al	PROPN
fnp-3806	3668	13	.	.	PROPN
fnp-3806	3668	14	metabolic	metabolic	PROPN
fnp-3806	3668	15	network	network	NOUN
fnp-3806	3668	16	of	of	ADP
fnp-3806	3668	17	nucleosides	nucleoside	NOUN
fnp-3806	3668	18	in	in	ADP
fnp-3806	3668	19	the	the	DET
fnp-3806	3668	20	brain	brain	NOUN
fnp-3806	3668	21	.	.	PUNCT
fnp-3806	3669	1	curr	curr	PROPN
fnp-3806	3669	2	top	top	ADJ
fnp-3806	3669	3	med	med	ADJ
fnp-3806	3669	4	chem	chem	NOUN
fnp-3806	3669	5	2011;11:909	2011;11:909	NUM
fnp-3806	3669	6	-	-	SYM
fnp-3806	3669	7	922	922	NUM
fnp-3806	3669	8	.	.	PUNCT
fnp-3806	3669	9	https://doi.org/10.2174/156802611795347555	https://doi.org/10.2174/156802611795347555	NOUN
fnp-3806	3669	10	ansoleaga	ansoleaga	PROPN
fnp-3806	3669	11	b	b	PROPN
fnp-3806	3669	12	,	,	PUNCT
fnp-3806	3669	13	jove	jove	PROPN
fnp-3806	3669	14	m	m	PROPN
fnp-3806	3669	15	,	,	PUNCT
fnp-3806	3669	16	schluter	schluter	PROPN
fnp-3806	3669	17	a	a	PROPN
fnp-3806	3669	18	,	,	PUNCT
fnp-3806	3669	19	et	et	PROPN
fnp-3806	3669	20	al	al	PROPN
fnp-3806	3669	21	.	.	PUNCT
fnp-3806	3669	22	deregulation	deregulation	NOUN
fnp-3806	3669	23	of	of	ADP
fnp-3806	3669	24	purine	purine	NOUN
fnp-3806	3669	25	metabolism	metabolism	NOUN
fnp-3806	3669	26	in	in	ADP
fnp-3806	3669	27	alzheimer	alzheimer	PROPN
fnp-3806	3669	28	’s	’s	PART
fnp-3806	3669	29	disease	disease	NOUN
fnp-3806	3669	30	.	.	PUNCT
fnp-3806	3670	1	neurobiol	neurobiol	PROPN
fnp-3806	3670	2	aging	age	VERB
fnp-3806	3670	3	2015;36:68	2015;36:68	PROPN
fnp-3806	3670	4	-	-	SYM
fnp-3806	3670	5	80	80	NUM
fnp-3806	3670	6	.	.	PUNCT
fnp-3806	3671	1	https://doi.org/10.1016/j.neurobiolaging.2014.08.004	https://doi.org/10.1016/j.neurobiolaging.2014.08.004	PROPN
fnp-3806	3671	2	rahman	rahman	PROPN
fnp-3806	3671	3	a.	a.	NOUN
fnp-3806	3671	4	the	the	DET
fnp-3806	3671	5	role	role	NOUN
fnp-3806	3671	6	of	of	ADP
fnp-3806	3671	7	adenosine	adenosine	NOUN
fnp-3806	3671	8	in	in	ADP
fnp-3806	3671	9	alzheimer	alzheimer	PROPN
fnp-3806	3671	10	’s	’s	PART
fnp-3806	3671	11	disease	disease	NOUN
fnp-3806	3671	12	.	.	PUNCT
fnp-3806	3672	1	curr	curr	PROPN
fnp-3806	3672	2	neuropharmacol	neuropharmacol	PROPN
fnp-3806	3672	3	2009	2009	NUM
fnp-3806	3672	4	;	;	PUNCT
fnp-3806	3672	5	7	7	NUM
fnp-3806	3672	6	:	:	SYM
fnp-3806	3672	7	207	207	NUM
fnp-3806	3672	8	-	-	SYM
fnp-3806	3672	9	216	216	NUM
fnp-3806	3672	10	.	.	PUNCT
fnp-3806	3673	1	https://doi.org/10.2174/157015909789152119	https://doi.org/10.2174/157015909789152119	X
fnp-3806	3673	2	carman	carman	PROPN
fnp-3806	3673	3	aj	aj	PROPN
fnp-3806	3673	4	,	,	PUNCT
fnp-3806	3673	5	mills	mills	PROPN
fnp-3806	3673	6	jh	jh	PROPN
fnp-3806	3673	7	,	,	PUNCT
fnp-3806	3673	8	krenz	krenz	PROPN
fnp-3806	3673	9	a	a	PROPN
fnp-3806	3673	10	,	,	PUNCT
fnp-3806	3673	11	et	et	PROPN
fnp-3806	3673	12	al	al	PROPN
fnp-3806	3673	13	.	.	PROPN
fnp-3806	3673	14	adenosine	adenosine	ADJ
fnp-3806	3673	15	receptor	receptor	NOUN
fnp-3806	3673	16	signaling	signal	VERB
fnp-3806	3673	17	modulates	modulate	NOUN
fnp-3806	3673	18	permeability	permeability	NOUN
fnp-3806	3673	19	of	of	ADP
fnp-3806	3673	20	the	the	DET
fnp-3806	3673	21	blood	blood	NOUN
fnp-3806	3673	22	-	-	PUNCT
fnp-3806	3673	23	brain	brain	NOUN
fnp-3806	3673	24	barrier	barrier	NOUN
fnp-3806	3673	25	.	.	PUNCT
fnp-3806	3674	1	j	j	PROPN
fnp-3806	3674	2	neurosci	neurosci	PROPN
fnp-3806	3674	3	2011	2011	NUM
fnp-3806	3674	4	;	;	PUNCT
fnp-3806	3674	5	31	31	NUM
fnp-3806	3674	6	:	:	SYM
fnp-3806	3674	7	13272	13272	NUM
fnp-3806	3674	8	-	-	SYM
fnp-3806	3674	9	13280	13280	NUM
fnp-3806	3674	10	.	.	PUNCT
fnp-3806	3675	1	https://doi.org/10.1523/jneurosci.3337-11.201	https://doi.org/10.1523/jneurosci.3337-11.201	VERB
fnp-3806	3675	2	alonso	alonso	NOUN
fnp-3806	3675	3	-	-	PUNCT
fnp-3806	3675	4	andrés	andrés	ADP
fnp-3806	3675	5	p	p	NOUN
fnp-3806	3675	6	,	,	PUNCT
fnp-3806	3675	7	albasanz	albasanz	PROPN
fnp-3806	3675	8	jl	jl	PROPN
fnp-3806	3675	9	,	,	PUNCT
fnp-3806	3675	10	ferrer	ferrer	PROPN
fnp-3806	3675	11	i	i	PROPN
fnp-3806	3675	12	,	,	PUNCT
fnp-3806	3675	13	et	et	PROPN
fnp-3806	3675	14	al	al	PROPN
fnp-3806	3675	15	.	.	PUNCT
fnp-3806	3675	16	purine	purine	NOUN
fnp-3806	3675	17	-	-	PUNCT
fnp-3806	3675	18	related	relate	VERB
fnp-3806	3675	19	metabolites	metabolite	NOUN
fnp-3806	3675	20	and	and	CCONJ
fnp-3806	3675	21	their	their	PRON
fnp-3806	3675	22	converting	convert	VERB
fnp-3806	3675	23	enzymes	enzyme	NOUN
fnp-3806	3675	24	are	be	AUX
fnp-3806	3675	25	altered	alter	VERB
fnp-3806	3675	26	in	in	ADP
fnp-3806	3675	27	frontal	frontal	ADJ
fnp-3806	3675	28	,	,	PUNCT
fnp-3806	3675	29	parietal	parietal	ADJ
fnp-3806	3675	30	and	and	CCONJ
fnp-3806	3675	31	temporal	temporal	ADJ
fnp-3806	3675	32	cortex	cortex	NOUN
fnp-3806	3675	33	at	at	ADP
fnp-3806	3675	34	early	early	ADJ
fnp-3806	3675	35	stages	stage	NOUN
fnp-3806	3675	36	of	of	ADP
fnp-3806	3675	37	alzheimer	alzheimer	PROPN
fnp-3806	3675	38	’s	’s	PART
fnp-3806	3675	39	disease	disease	NOUN
fnp-3806	3675	40	pathology	pathology	PROPN
fnp-3806	3675	41	.	.	PUNCT
fnp-3806	3676	1	brain	brain	NOUN
fnp-3806	3676	2	pathol	pathol	PROPN
fnp-3806	3676	3	2018;28	2018;28	NOUN
fnp-3806	3676	4	:	:	PUNCT
fnp-3806	3676	5	933	933	NUM
fnp-3806	3676	6	-	-	SYM
fnp-3806	3676	7	946	946	NUM
fnp-3806	3676	8	.	.	PUNCT
fnp-3806	3677	1	https://doi.org/10.1111/bpa.12592	https://doi.org/10.1111/bpa.12592	PROPN
fnp-3806	3677	2	panza	panza	X
fnp-3806	3677	3	f	f	PROPN
fnp-3806	3677	4	,	,	PUNCT
fnp-3806	3677	5	frisardi	frisardi	ADJ
fnp-3806	3677	6	v	v	NOUN
fnp-3806	3677	7	,	,	PUNCT
fnp-3806	3677	8	capurso	capurso	ADP
fnp-3806	3677	9	c	c	NOUN
fnp-3806	3677	10	,	,	PUNCT
fnp-3806	3677	11	et	et	PROPN
fnp-3806	3677	12	al	al	PROPN
fnp-3806	3677	13	.	.	PROPN
fnp-3806	3678	1	polyunsaturated	polyunsaturate	VERB
fnp-3806	3678	2	fatty	fatty	NOUN
fnp-3806	3678	3	acid	acid	NOUN
fnp-3806	3678	4	and	and	CCONJ
fnp-3806	3678	5	s	s	NOUN
fnp-3806	3678	6	-	-	PUNCT
fnp-3806	3678	7	adenosylmethionine	adenosylmethionine	NOUN
fnp-3806	3678	8	supplementation	supplementation	NOUN
fnp-3806	3678	9	in	in	ADP
fnp-3806	3678	10	predementia	predementia	PROPN
fnp-3806	3678	11	syndromes	syndrome	NOUN
fnp-3806	3678	12	and	and	CCONJ
fnp-3806	3678	13	alzheimer	alzheimer	PROPN
fnp-3806	3678	14	’s	’s	PART
fnp-3806	3678	15	disease	disease	NOUN
fnp-3806	3678	16	:	:	PUNCT
fnp-3806	3678	17	a	a	DET
fnp-3806	3678	18	review	review	NOUN
fnp-3806	3678	19	.	.	PUNCT
fnp-3806	3679	1	scientificworldjournal	scientificworldjournal	ADJ
fnp-3806	3679	2	2009;9:373	2009;9:373	NOUN
fnp-3806	3679	3	-	-	SYM
fnp-3806	3679	4	389	389	NUM
fnp-3806	3679	5	.	.	PUNCT
fnp-3806	3680	1	https://doi.org/10.1100/tsw.2009.48	https://doi.org/10.1100/tsw.2009.48	PROPN
fnp-3806	3681	1	ruan	ruan	PROPN
fnp-3806	3681	2	q	q	PROPN
fnp-3806	3681	3	,	,	PUNCT
fnp-3806	3681	4	ruan	ruan	PROPN
fnp-3806	3681	5	j	j	PROPN
fnp-3806	3681	6	,	,	PUNCT
fnp-3806	3681	7	zhang	zhang	PROPN
fnp-3806	3681	8	w	w	PROPN
fnp-3806	3681	9	,	,	PUNCT
fnp-3806	3681	10	qian	qian	PROPN
fnp-3806	3681	11	f	f	PROPN
fnp-3806	3681	12	,	,	PUNCT
fnp-3806	3681	13	et	et	PROPN
fnp-3806	3681	14	al	al	PROPN
fnp-3806	3681	15	.	.	PUNCT
fnp-3806	3681	16	targeting	target	VERB
fnp-3806	3681	17	nad(+	nad(+	PROPN
fnp-3806	3681	18	)	)	PUNCT
fnp-3806	3681	19	degradation	degradation	NOUN
fnp-3806	3681	20	:	:	PUNCT
fnp-3806	3681	21	the	the	DET
fnp-3806	3681	22	therapeutic	therapeutic	ADJ
fnp-3806	3681	23	potential	potential	NOUN
fnp-3806	3681	24	of	of	ADP
fnp-3806	3681	25	flavonoids	flavonoid	NOUN
fnp-3806	3681	26	for	for	ADP
fnp-3806	3681	27	alzheimer	alzheimer	PROPN
fnp-3806	3681	28	's	's	PART
fnp-3806	3681	29	disease	disease	NOUN
fnp-3806	3681	30	and	and	CCONJ
fnp-3806	3681	31	cognitive	cognitive	ADJ
fnp-3806	3681	32	frailty	frailty	NOUN
fnp-3806	3681	33	.	.	PUNCT
fnp-3806	3682	1	pharmacol	pharmacol	NOUN
fnp-3806	3682	2	res	re	NOUN
fnp-3806	3682	3	2018;128:345	2018;128:345	NUM
fnp-3806	3682	4	-	-	SYM
fnp-3806	3682	5	358	358	NUM
fnp-3806	3682	6	.	.	PUNCT
fnp-3806	3683	1	https://doi.org/10.1016/j.phrs.2017.08.010	https://doi.org/10.1016/j.phrs.2017.08.010	NOUN
fnp-3806	3683	2	erb	erb	PROPN
fnp-3806	3683	3	l	l	PROPN
fnp-3806	3683	4	,	,	PUNCT
fnp-3806	3683	5	woods	woods	PROPN
fnp-3806	3683	6	lt	lt	PROPN
fnp-3806	3683	7	,	,	PUNCT
fnp-3806	3683	8	khalafalla	khalafalla	PROPN
fnp-3806	3683	9	mg	mg	PROPN
fnp-3806	3683	10	,	,	PUNCT
fnp-3806	3683	11	et	et	PROPN
fnp-3806	3683	12	al	al	PROPN
fnp-3806	3683	13	.	.	PROPN
fnp-3806	3683	14	purinergic	purinergic	PROPN
fnp-3806	3683	15	signalling	signal	VERB
fnp-3806	3683	16	in	in	ADP
fnp-3806	3683	17	alzheimer	alzheimer	PROPN
fnp-3806	3683	18	’s	’s	PART
fnp-3806	3683	19	disease	disease	NOUN
fnp-3806	3683	20	.	.	PUNCT
fnp-3806	3684	1	brain	brain	NOUN
fnp-3806	3684	2	res	re	NOUN
fnp-3806	3684	3	bull	bull	NOUN
fnp-3806	3684	4	2019;151:25	2019;151:25	NOUN
fnp-3806	3684	5	-	-	SYM
fnp-3806	3684	6	37	37	NUM
fnp-3806	3684	7	.	.	PUNCT
fnp-3806	3685	1	https://doi.org/10.1016/j.brainresbull.2018.10.014	https://doi.org/10.1016/j.brainresbull.2018.10.014	PROPN
fnp-3806	3685	2	sharma	sharma	PROPN
fnp-3806	3685	3	vk	vk	PROPN
fnp-3806	3685	4	,	,	PUNCT
fnp-3806	3685	5	singh	singh	PROPN
fnp-3806	3685	6	tg	tg	PROPN
fnp-3806	3685	7	,	,	PUNCT
fnp-3806	3685	8	singh	singh	PROPN
fnp-3806	3685	9	s.	s.	PROPN
fnp-3806	3685	10	cyclic	cyclic	PROPN
fnp-3806	3685	11	nucleotides	nucleotide	NOUN
fnp-3806	3685	12	signaling	signal	VERB
fnp-3806	3685	13	and	and	CCONJ
fnp-3806	3685	14	phosphodiesterase	phosphodiesterase	NOUN
fnp-3806	3685	15	inhibition	inhibition	NOUN
fnp-3806	3685	16	:	:	PUNCT
fnp-3806	3685	17	defying	defy	VERB
fnp-3806	3685	18	alzheimer	alzheimer	PROPN
fnp-3806	3685	19	's	's	PART
fnp-3806	3685	20	disease	disease	NOUN
fnp-3806	3685	21	.	.	PUNCT
fnp-3806	3686	1	curr	curr	PROPN
fnp-3806	3686	2	drug	drug	NOUN
fnp-3806	3686	3	targets	target	NOUN
fnp-3806	3686	4	2020;21:1371	2020;21:1371	PROPN
fnp-3806	3686	5	-	-	SYM
fnp-3806	3686	6	1384	1384	NUM
fnp-3806	3686	7	.	.	PUNCT
fnp-3806	3687	1	https://doi.org/10.2174/1389450121666200727104728	https://doi.org/10.2174/1389450121666200727104728	NOUN
fnp-3806	3687	2	merighi	merighi	PROPN
fnp-3806	3687	3	s	s	PROPN
fnp-3806	3687	4	,	,	PUNCT
fnp-3806	3687	5	poloni	poloni	VERB
fnp-3806	3687	6	te	te	PROPN
fnp-3806	3687	7	,	,	PUNCT
fnp-3806	3687	8	terrazzan	terrazzan	PROPN
fnp-3806	3687	9	a	a	X
fnp-3806	3687	10	,	,	PUNCT
fnp-3806	3687	11	et	et	PROPN
fnp-3806	3687	12	al	al	PROPN
fnp-3806	3687	13	.	.	PROPN
fnp-3806	3687	14	alzheimer	alzheimer	PROPN
fnp-3806	3687	15	and	and	CCONJ
fnp-3806	3687	16	purinergic	purinergic	NOUN
fnp-3806	3687	17	signaling	signal	VERB
fnp-3806	3687	18	:	:	PUNCT
fnp-3806	3687	19	just	just	ADV
fnp-3806	3687	20	a	a	DET
fnp-3806	3687	21	matter	matter	NOUN
fnp-3806	3687	22	of	of	ADP
fnp-3806	3687	23	inflammation	inflammation	NOUN
fnp-3806	3687	24	?	?	PUNCT
fnp-3806	3688	1	cells	cell	NOUN
fnp-3806	3688	2	2021;10:1267	2021;10:1267	PROPN
fnp-3806	3688	3	.	.	PUNCT
fnp-3806	3688	4	https://doi.org/10.3390/cells10051267	https://doi.org/10.3390/cells10051267	PROPN
fnp-3806	3688	5	pan	pan	PROPN
fnp-3806	3688	6	l	l	PROPN
fnp-3806	3688	7	,	,	PUNCT
fnp-3806	3688	8	ma	ma	PROPN
fnp-3806	3688	9	y	y	PROPN
fnp-3806	3688	10	,	,	PUNCT
fnp-3806	3688	11	li	li	PROPN
fnp-3806	3688	12	y	y	PROPN
fnp-3806	3688	13	,	,	PUNCT
fnp-3806	3688	14	wu	wu	PROPN
fnp-3806	3688	15	h	h	PROPN
fnp-3806	3688	16	,	,	PUNCT
fnp-3806	3688	17	et	et	PROPN
fnp-3806	3688	18	al	al	PROPN
fnp-3806	3688	19	.	.	PUNCT
fnp-3806	3689	1	the	the	DET
fnp-3806	3689	2	therapeutic	therapeutic	ADJ
fnp-3806	3689	3	potential	potential	NOUN
fnp-3806	3689	4	of	of	ADP
fnp-3806	3689	5	purinergic	purinergic	NOUN
fnp-3806	3689	6	receptors	receptor	NOUN
fnp-3806	3689	7	in	in	ADP
fnp-3806	3689	8	alzheimer	alzheimer	PROPN
fnp-3806	3689	9	's	's	PART
fnp-3806	3689	10	disease	disease	NOUN
fnp-3806	3689	11	and	and	CCONJ
fnp-3806	3689	12	promising	promise	VERB
fnp-3806	3689	13	therapeutic	therapeutic	ADJ
fnp-3806	3689	14	modulators	modulator	NOUN
fnp-3806	3689	15	.	.	PUNCT
fnp-3806	3690	1	mini	mini	PROPN
fnp-3806	3690	2	rev	rev	PROPN
fnp-3806	3690	3	med	med	PROPN
fnp-3806	3690	4	chem	chem	NOUN
fnp-3806	3690	5	2021;21:1288	2021;21:1288	NUM
fnp-3806	3690	6	-	-	SYM
fnp-3806	3690	7	1302	1302	NUM
fnp-3806	3690	8	.	.	PUNCT
fnp-3806	3691	1	https://doi.org/10.2174/1389557520999201209211610	https://doi.org/10.2174/1389557520999201209211610	X
fnp-3806	3692	1	kundu	kundu	PROPN
fnp-3806	3692	2	d	d	PROPN
fnp-3806	3692	3	,	,	PUNCT
fnp-3806	3692	4	dubey	dubey	PROPN
fnp-3806	3692	5	vk	vk	PROPN
fnp-3806	3692	6	.	.	PUNCT
fnp-3806	3692	7	purines	purine	NOUN
fnp-3806	3692	8	and	and	CCONJ
fnp-3806	3692	9	pyrimidines	pyrimidine	NOUN
fnp-3806	3692	10	:	:	PUNCT
fnp-3806	3692	11	metabolism	metabolism	NOUN
fnp-3806	3692	12	,	,	PUNCT
fnp-3806	3692	13	function	function	NOUN
fnp-3806	3692	14	and	and	CCONJ
fnp-3806	3692	15	potential	potential	NOUN
fnp-3806	3692	16	as	as	ADP
fnp-3806	3692	17	therapeutic	therapeutic	ADJ
fnp-3806	3692	18	options	option	NOUN
fnp-3806	3692	19	in	in	ADP
fnp-3806	3692	20	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3692	21	diseases	disease	NOUN
fnp-3806	3692	22	.	.	PUNCT
fnp-3806	3693	1	curr	curr	PROPN
fnp-3806	3693	2	protein	protein	NOUN
fnp-3806	3693	3	pept	pept	VERB
fnp-3806	3693	4	sci	sci	PROPN
fnp-3806	3693	5	2021;22:170	2021;22:170	PROPN
fnp-3806	3693	6	-	-	SYM
fnp-3806	3693	7	189	189	NUM
fnp-3806	3693	8	.	.	PUNCT
fnp-3806	3694	1	https://doi.org/10.2174/1389203721999201208200605	https://doi.org/10.2174/1389203721999201208200605	PROPN
fnp-3806	3695	1	allis	allis	PROPN
fnp-3806	3695	2	cd	cd	PROPN
fnp-3806	3695	3	,	,	PUNCT
fnp-3806	3695	4	caparros	caparro	NOUN
fnp-3806	3695	5	ml	ml	VERB
fnp-3806	3695	6	,	,	PUNCT
fnp-3806	3695	7	jenuwein	jenuwein	PROPN
fnp-3806	3695	8	t	t	PROPN
fnp-3806	3695	9	,	,	PUNCT
fnp-3806	3695	10	et	et	PROPN
fnp-3806	3695	11	al	al	PROPN
fnp-3806	3695	12	.	.	PUNCT
fnp-3806	3696	1	epigenetics	epigenetics	PROPN
fnp-3806	3696	2	second	second	ADJ
fnp-3806	3696	3	edit	edit	NOUN
fnp-3806	3696	4	.	.	PUNCT
fnp-3806	3697	1	cold	cold	ADJ
fnp-3806	3697	2	springer	springer	PROPN
fnp-3806	3697	3	arbor	arbor	PROPN
fnp-3806	3697	4	laboratory	laboratory	PROPN
fnp-3806	3697	5	press	press	PROPN
fnp-3806	3697	6	2015	2015	NUM
fnp-3806	3697	7	.	.	PUNCT
fnp-3806	3698	1	paro	paro	PROPN
fnp-3806	3698	2	r	r	PROPN
fnp-3806	3698	3	,	,	PUNCT
fnp-3806	3698	4	grossniklaus	grossniklaus	NOUN
fnp-3806	3698	5	u	u	NOUN
fnp-3806	3698	6	,	,	PUNCT
fnp-3806	3698	7	santoro	santoro	PROPN
fnp-3806	3698	8	r	r	NOUN
fnp-3806	3698	9	,	,	PUNCT
fnp-3806	3698	10	wutz	wutz	ADJ
fnp-3806	3698	11	a.	a.	NOUN
fnp-3806	3698	12	introduction	introduction	NOUN
fnp-3806	3698	13	to	to	ADP
fnp-3806	3698	14	epigenetics	epigenetic	NOUN
fnp-3806	3698	15	,	,	PUNCT
fnp-3806	3698	16	springer	springer	NOUN
fnp-3806	3698	17	,	,	PUNCT
fnp-3806	3698	18	2021	2021	NUM
fnp-3806	3698	19	wu	wu	PROPN
fnp-3806	3698	20	h	h	PROPN
fnp-3806	3698	21	,	,	PUNCT
fnp-3806	3698	22	tao	tao	PROPN
fnp-3806	3698	23	j	j	PROPN
fnp-3806	3698	24	,	,	PUNCT
fnp-3806	3698	25	sun	sun	PROPN
fnp-3806	3698	26	ye	ye	PROPN
fnp-3806	3698	27	.	.	PROPN
fnp-3806	3698	28	regulation	regulation	NOUN
fnp-3806	3698	29	and	and	CCONJ
fnp-3806	3698	30	function	function	NOUN
fnp-3806	3698	31	of	of	ADP
fnp-3806	3698	32	mammalian	mammalian	ADJ
fnp-3806	3698	33	dna	dna	PROPN
fnp-3806	3698	34	methylation	methylation	NOUN
fnp-3806	3698	35	patterns	pattern	NOUN
fnp-3806	3698	36	:	:	PUNCT
fnp-3806	3698	37	a	a	DET
fnp-3806	3698	38	genomic	genomic	NOUN
fnp-3806	3698	39	perspective	perspective	NOUN
fnp-3806	3698	40	.	.	PUNCT
fnp-3806	3699	1	brief	brief	ADJ
fnp-3806	3699	2	funct	funct	ADJ
fnp-3806	3699	3	genomics	genomics	NOUN
fnp-3806	3699	4	.	.	PUNCT
fnp-3806	3700	1	2012;11:240	2012;11:240	NUM
fnp-3806	3700	2	-	-	SYM
fnp-3806	3700	3	250	250	NUM
fnp-3806	3700	4	.	.	PUNCT
fnp-3806	3701	1	https://doi.org/10.1093/bfgp/els01	https://doi.org/10.1093/bfgp/els01	PROPN
fnp-3806	3701	2	qazi	qazi	PROPN
fnp-3806	3701	3	tj	tj	PROPN
fnp-3806	3701	4	,	,	PUNCT
fnp-3806	3701	5	quan	quan	PROPN
fnp-3806	3701	6	z	z	PROPN
fnp-3806	3701	7	,	,	PUNCT
fnp-3806	3701	8	mir	mir	PROPN
fnp-3806	3701	9	a	a	PRON
fnp-3806	3701	10	,	,	PUNCT
fnp-3806	3701	11	qing	qe	VERB
fnp-3806	3701	12	h.	h.	PROPN
fnp-3806	3701	13	epigenetics	epigenetics	PROPN
fnp-3806	3701	14	in	in	ADP
fnp-3806	3701	15	alzheimer	alzheimer	PROPN
fnp-3806	3701	16	's	's	PART
fnp-3806	3701	17	disease	disease	NOUN
fnp-3806	3701	18	:	:	PUNCT
fnp-3806	3701	19	perspective	perspective	NOUN
fnp-3806	3701	20	of	of	ADP
fnp-3806	3701	21	dna	dna	PROPN
fnp-3806	3701	22	methylation	methylation	NOUN
fnp-3806	3701	23	.	.	PUNCT
fnp-3806	3702	1	mol	mol	ADP
fnp-3806	3702	2	neurobiol	neurobiol	PROPN
fnp-3806	3702	3	2018;55:1026	2018;55:1026	PROPN
fnp-3806	3702	4	-	-	SYM
fnp-3806	3702	5	1044	1044	NUM
fnp-3806	3702	6	.	.	PUNCT
fnp-3806	3703	1	https://doi.org/10.1007/s12035-016-0357-6	https://doi.org/10.1007/s12035-016-0357-6	PROPN
fnp-3806	3703	2	grunstein	grunstein	PROPN
fnp-3806	3703	3	m.	m.	NOUN
fnp-3806	3703	4	histone	histone	NOUN
fnp-3806	3703	5	acetylation	acetylation	NOUN
fnp-3806	3703	6	in	in	ADP
fnp-3806	3703	7	chromatin	chromatin	NOUN
fnp-3806	3703	8	structure	structure	NOUN
fnp-3806	3703	9	and	and	CCONJ
fnp-3806	3703	10	transcription	transcription	NOUN
fnp-3806	3703	11	.	.	PUNCT
fnp-3806	3704	1	nature	nature	NOUN
fnp-3806	3704	2	1997;389	1997;389	NUM
fnp-3806	3704	3	:	:	PUNCT
fnp-3806	3704	4	349	349	NUM
fnp-3806	3704	5	-	-	SYM
fnp-3806	3704	6	352	352	NUM
fnp-3806	3704	7	.	.	PUNCT
fnp-3806	3705	1	https://doi.org/10.1038/38664	https://doi.org/10.1038/38664	PROPN
fnp-3806	3705	2	kuo	kuo	PROPN
fnp-3806	3705	3	mh	mh	PROPN
fnp-3806	3705	4	,	,	PUNCT
fnp-3806	3705	5	allis	allis	PROPN
fnp-3806	3705	6	cd	cd	PROPN
fnp-3806	3705	7	.	.	PUNCT
fnp-3806	3705	8	roles	role	NOUN
fnp-3806	3705	9	of	of	ADP
fnp-3806	3705	10	histone	histone	NOUN
fnp-3806	3705	11	acetyltransferases	acetyltransferase	NOUN
fnp-3806	3705	12	and	and	CCONJ
fnp-3806	3705	13	deacetylases	deacetylase	NOUN
fnp-3806	3705	14	in	in	ADP
fnp-3806	3705	15	gene	gene	NOUN
fnp-3806	3705	16	regulation	regulation	NOUN
fnp-3806	3705	17	.	.	PUNCT
fnp-3806	3706	1	bioessays	bioessay	NOUN
fnp-3806	3706	2	1998	1998	NUM
fnp-3806	3706	3	;	;	PUNCT
fnp-3806	3706	4	20	20	NUM
fnp-3806	3706	5	:	:	SYM
fnp-3806	3706	6	615	615	NUM
fnp-3806	3706	7	-	-	SYM
fnp-3806	3706	8	626	626	NUM
fnp-3806	3706	9	.	.	PUNCT
fnp-3806	3707	1	https://doi.org/10.1002/(sici)1521-1878(199808)20:8<615::aid-bies4>3.0.co;2-h	https://doi.org/10.1002/(sici)1521-1878(199808)20:8<615::aid-bies4>3.0.co;2-h	PROPN
fnp-3806	3707	2	de	de	PROPN
fnp-3806	3707	3	ruijter	ruijter	PROPN
fnp-3806	3707	4	aj	aj	PROPN
fnp-3806	3707	5	,	,	PUNCT
fnp-3806	3707	6	van	van	PROPN
fnp-3806	3707	7	gennip	gennip	PROPN
fnp-3806	3707	8	ah	ah	INTJ
fnp-3806	3707	9	,	,	PUNCT
fnp-3806	3707	10	caron	caron	PROPN
fnp-3806	3707	11	hn	hn	PROPN
fnp-3806	3707	12	,	,	PUNCT
fnp-3806	3707	13	et	et	PROPN
fnp-3806	3707	14	al	al	PROPN
fnp-3806	3707	15	.	.	PUNCT
fnp-3806	3708	1	histone	histone	NOUN
fnp-3806	3708	2	deacetylases	deacetylase	NOUN
fnp-3806	3708	3	(	(	PUNCT
fnp-3806	3708	4	hdacs	hdac	NOUN
fnp-3806	3708	5	):	):	PUNCT
fnp-3806	3708	6	characterization	characterization	NOUN
fnp-3806	3708	7	of	of	ADP
fnp-3806	3708	8	the	the	DET
fnp-3806	3708	9	classical	classical	ADJ
fnp-3806	3708	10	hdac	hdac	NOUN
fnp-3806	3708	11	family	family	NOUN
fnp-3806	3708	12	.	.	PUNCT
fnp-3806	3709	1	biochem	biochem	PROPN
fnp-3806	3709	2	j	j	PROPN
fnp-3806	3709	3	2003;370:737	2003;370:737	NUM
fnp-3806	3709	4	-	-	SYM
fnp-3806	3709	5	749	749	NUM
fnp-3806	3709	6	.	.	PUNCT
fnp-3806	3710	1	https://doi.org/10.1042/bj20021321	https://doi.org/10.1042/bj20021321	PRON
fnp-3806	3710	2	torok	torok	PROPN
fnp-3806	3710	3	ms	ms	PROPN
fnp-3806	3710	4	,	,	PUNCT
fnp-3806	3710	5	grant	grant	PROPN
fnp-3806	3710	6	pa	pa	PROPN
fnp-3806	3710	7	.	.	PUNCT
fnp-3806	3711	1	histone	histone	PROPN
fnp-3806	3711	2	acetyltransferase	acetyltransferase	ADJ
fnp-3806	3711	3	proteins	protein	NOUN
fnp-3806	3711	4	contribute	contribute	VERB
fnp-3806	3711	5	to	to	ADP
fnp-3806	3711	6	transcriptional	transcriptional	ADJ
fnp-3806	3711	7	processes	process	NOUN
fnp-3806	3711	8	at	at	ADP
fnp-3806	3711	9	multiple	multiple	ADJ
fnp-3806	3711	10	levels	level	NOUN
fnp-3806	3711	11	.	.	PUNCT
fnp-3806	3712	1	adv	adv	PROPN
fnp-3806	3712	2	protein	protein	NOUN
fnp-3806	3712	3	chem	chem	NOUN
fnp-3806	3712	4	2004;67:181	2004;67:181	NUM
fnp-3806	3712	5	-	-	SYM
fnp-3806	3712	6	199	199	NUM
fnp-3806	3712	7	.	.	PUNCT
fnp-3806	3713	1	https://doi.org/10.1016/s0065-3233(04)67007-0	https://doi.org/10.1016/s0065-3233(04)67007-0	PROPN
fnp-3806	3713	2	cheung	cheung	PROPN
fnp-3806	3713	3	p	p	X
fnp-3806	3713	4	,	,	PUNCT
fnp-3806	3713	5	lau	lau	PROPN
fnp-3806	3713	6	p.	p.	PROPN
fnp-3806	3713	7	epigenetic	epigenetic	ADJ
fnp-3806	3713	8	regulation	regulation	NOUN
fnp-3806	3713	9	by	by	ADP
fnp-3806	3713	10	histone	histone	NOUN
fnp-3806	3713	11	methylation	methylation	NOUN
fnp-3806	3713	12	and	and	CCONJ
fnp-3806	3713	13	histone	histone	NOUN
fnp-3806	3713	14	variants	variant	NOUN
fnp-3806	3713	15	.	.	PUNCT
fnp-3806	3714	1	mol	mol	ADP
fnp-3806	3714	2	endocrin	endocrin	NOUN
fnp-3806	3714	3	2005;19:563	2005;19:563	PROPN
fnp-3806	3714	4	-	-	SYM
fnp-3806	3714	5	573	573	NUM
fnp-3806	3714	6	.	.	PUNCT
fnp-3806	3714	7	https://doi.org/10.1210/me.2004-0496	https://doi.org/10.1210/me.2004-0496	NOUN
fnp-3806	3714	8	imhof	imhof	PROPN
fnp-3806	3714	9	a.	a.	NOUN
fnp-3806	3714	10	epigenetic	epigenetic	ADJ
fnp-3806	3714	11	regulators	regulator	NOUN
fnp-3806	3714	12	and	and	CCONJ
fnp-3806	3714	13	histone	histone	NOUN
fnp-3806	3714	14	modification	modification	NOUN
fnp-3806	3714	15	.	.	PUNCT
fnp-3806	3715	1	brief	brief	ADJ
fnp-3806	3715	2	funct	funct	ADJ
fnp-3806	3715	3	genomic	genomic	ADJ
fnp-3806	3715	4	proteomic	proteomic	NOUN
fnp-3806	3715	5	2006;5:222	2006;5:222	NUM
fnp-3806	3715	6	-	-	SYM
fnp-3806	3715	7	227	227	NUM
fnp-3806	3715	8	.	.	PUNCT
fnp-3806	3716	1	https://doi.org/10.1093/bfgp/ell030	https://doi.org/10.1093/bfgp/ell030	PROPN
fnp-3806	3716	2	gupta	gupta	PROPN
fnp-3806	3716	3	s	s	PROPN
fnp-3806	3716	4	,	,	PUNCT
fnp-3806	3716	5	kim	kim	PROPN
fnp-3806	3716	6	sy	sy	PROPN
fnp-3806	3716	7	,	,	PUNCT
fnp-3806	3716	8	artis	artis	PROPN
fnp-3806	3716	9	s	s	PROPN
fnp-3806	3716	10	,	,	PUNCT
fnp-3806	3716	11	et	et	PROPN
fnp-3806	3716	12	al	al	PROPN
fnp-3806	3716	13	.	.	PUNCT
fnp-3806	3717	1	histone	histone	PROPN
fnp-3806	3717	2	methylation	methylation	NOUN
fnp-3806	3717	3	regulates	regulate	VERB
fnp-3806	3717	4	memory	memory	NOUN
fnp-3806	3717	5	formation	formation	NOUN
fnp-3806	3717	6	.	.	PUNCT
fnp-3806	3718	1	j	j	PROPN
fnp-3806	3718	2	neurosci	neurosci	PROPN
fnp-3806	3718	3	2010	2010	NUM
fnp-3806	3718	4	;	;	PUNCT
fnp-3806	3718	5	30:3589–3599	30:3589–3599	NUM
fnp-3806	3718	6	.	.	PUNCT
fnp-3806	3719	1	https://doi.org/10.1523/jneurosci.3732-09.2010	https://doi.org/10.1523/jneurosci.3732-09.2010	PROPN
fnp-3806	3719	2	greer	greer	PROPN
fnp-3806	3719	3	el	el	PROPN
fnp-3806	3719	4	,	,	PUNCT
fnp-3806	3719	5	shi	shi	PROPN
fnp-3806	3719	6	y.	y.	PROPN
fnp-3806	3719	7	histone	histone	PROPN
fnp-3806	3719	8	methylation	methylation	NOUN
fnp-3806	3719	9	:	:	PUNCT
fnp-3806	3719	10	a	a	DET
fnp-3806	3719	11	dynamic	dynamic	ADJ
fnp-3806	3719	12	mark	mark	NOUN
fnp-3806	3719	13	in	in	ADP
fnp-3806	3719	14	health	health	NOUN
fnp-3806	3719	15	,	,	PUNCT
fnp-3806	3719	16	disease	disease	NOUN
fnp-3806	3719	17	and	and	CCONJ
fnp-3806	3719	18	inheritance	inheritance	NOUN
fnp-3806	3719	19	.	.	PUNCT
fnp-3806	3720	1	nature	nature	NOUN
fnp-3806	3720	2	rev	rev	VERB
fnp-3806	3720	3	genet	genet	PROPN
fnp-3806	3720	4	2012	2012	NUM
fnp-3806	3720	5	;	;	PUNCT
fnp-3806	3720	6	13:343	13:343	NUM
fnp-3806	3720	7	-	-	SYM
fnp-3806	3720	8	357	357	NUM
fnp-3806	3720	9	.	.	PUNCT
fnp-3806	3721	1	https://doi.org/10.1038/nrg3173	https://doi.org/10.1038/nrg3173	PROPN
fnp-3806	3721	2	morrison	morrison	PROPN
fnp-3806	3721	3	ld	ld	PROPN
fnp-3806	3721	4	,	,	PUNCT
fnp-3806	3721	5	smith	smith	PROPN
fnp-3806	3721	6	dd	dd	PROPN
fnp-3806	3721	7	,	,	PUNCT
fnp-3806	3721	8	kish	kish	PROPN
fnp-3806	3721	9	sj	sj	PROPN
fnp-3806	3721	10	.	.	PUNCT
fnp-3806	3721	11	brain	brain	PROPN
fnp-3806	3721	12	s	s	PROPN
fnp-3806	3721	13	-	-	PUNCT
fnp-3806	3721	14	adenosylmethionine	adenosylmethionine	NOUN
fnp-3806	3721	15	levels	level	NOUN
fnp-3806	3721	16	are	be	AUX
fnp-3806	3721	17	severely	severely	ADV
fnp-3806	3721	18	decreased	decrease	VERB
fnp-3806	3721	19	in	in	ADP
fnp-3806	3721	20	alzheimer	alzheimer	PROPN
fnp-3806	3721	21	’s	’s	PART
fnp-3806	3721	22	disease	disease	NOUN
fnp-3806	3721	23	.	.	PUNCT
fnp-3806	3722	1	j	j	PROPN
fnp-3806	3722	2	neurochem	neurochem	PROPN
fnp-3806	3722	3	1996;67:1328	1996;67:1328	NUM
fnp-3806	3722	4	-	-	SYM
fnp-3806	3722	5	1331	1331	NUM
fnp-3806	3722	6	.	.	PUNCT
fnp-3806	3723	1	https://doi.org/10.1046/j.1471-4159.1996.67031328.x	https://doi.org/10.1046/j.1471-4159.1996.67031328.x	NOUN
fnp-3806	3723	2	tahiliani	tahiliani	PROPN
fnp-3806	3723	3	m	m	PROPN
fnp-3806	3723	4	,	,	PUNCT
fnp-3806	3723	5	koh	koh	PROPN
fnp-3806	3723	6	kp	kp	PROPN
fnp-3806	3723	7	,	,	PUNCT
fnp-3806	3723	8	shen	shen	PROPN
fnp-3806	3723	9	y	y	PROPN
fnp-3806	3723	10	,	,	PUNCT
fnp-3806	3723	11	et	et	PROPN
fnp-3806	3723	12	al	al	PROPN
fnp-3806	3723	13	.	.	PUNCT
fnp-3806	3723	14	conversion	conversion	NOUN
fnp-3806	3723	15	of	of	ADP
fnp-3806	3723	16	5	5	NUM
fnp-3806	3723	17	-	-	PUNCT
fnp-3806	3723	18	methylcytosine	methylcytosine	NOUN
fnp-3806	3723	19	to	to	ADP
fnp-3806	3723	20	5	5	NUM
fnp-3806	3723	21	-	-	PUNCT
fnp-3806	3723	22	hydroxymethylcytosine	hydroxymethylcytosine	NOUN
fnp-3806	3723	23	in	in	ADP
fnp-3806	3723	24	mammalian	mammalian	ADJ
fnp-3806	3723	25	dna	dna	PROPN
fnp-3806	3723	26	by	by	ADP
fnp-3806	3723	27	mll	mll	PROPN
fnp-3806	3723	28	partner	partner	PROPN
fnp-3806	3723	29	tet1	tet1	PROPN
fnp-3806	3723	30	.	.	PUNCT
fnp-3806	3724	1	science	science	PROPN
fnp-3806	3724	2	2009;324:930–935	2009;324:930–935	NUM
fnp-3806	3724	3	.	.	PUNCT
fnp-3806	3725	1	https://doi.org/10.1126/science.1170116	https://doi.org/10.1126/science.1170116	PROPN
fnp-3806	3725	2	mastroeni	mastroeni	PROPN
fnp-3806	3725	3	d	d	NOUN
fnp-3806	3725	4	,	,	PUNCT
fnp-3806	3725	5	mckee	mckee	PROPN
fnp-3806	3725	6	a	a	PROPN
fnp-3806	3725	7	,	,	PUNCT
fnp-3806	3725	8	grover	grover	PROPN
fnp-3806	3725	9	a	a	PROPN
fnp-3806	3725	10	,	,	PUNCT
fnp-3806	3725	11	et	et	PROPN
fnp-3806	3725	12	al	al	PROPN
fnp-3806	3725	13	.	.	PUNCT
fnp-3806	3725	14	epigenetic	epigenetic	ADJ
fnp-3806	3725	15	differences	difference	NOUN
fnp-3806	3725	16	in	in	ADP
fnp-3806	3725	17	cortical	cortical	ADJ
fnp-3806	3725	18	neurons	neuron	NOUN
fnp-3806	3725	19	from	from	ADP
fnp-3806	3725	20	a	a	DET
fnp-3806	3725	21	pair	pair	NOUN
fnp-3806	3725	22	of	of	ADP
fnp-3806	3725	23	monozygotic	monozygotic	ADJ
fnp-3806	3725	24	twins	twin	NOUN
fnp-3806	3725	25	discordant	discordant	ADJ
fnp-3806	3725	26	for	for	ADP
fnp-3806	3725	27	alzheimer	alzheimer	PROPN
fnp-3806	3725	28	’s	’s	PART
fnp-3806	3725	29	disease	disease	NOUN
fnp-3806	3725	30	.	.	PUNCT
fnp-3806	3726	1	plos	plos	PROPN
fnp-3806	3726	2	one	one	NUM
fnp-3806	3726	3	2009	2009	NUM
fnp-3806	3726	4	;	;	PUNCT
fnp-3806	3726	5	4	4	NUM
fnp-3806	3726	6	e6617	e6617	NOUN
fnp-3806	3726	7	.	.	PUNCT
fnp-3806	3727	1	https://doi.org/10.1371/journal.pone.0006617	https://doi.org/10.1371/journal.pone.0006617	NUM
fnp-3806	3727	2	tan	tan	PROPN
fnp-3806	3727	3	l	l	NOUN
fnp-3806	3727	4	,	,	PUNCT
fnp-3806	3727	5	shi	shi	PROPN
fnp-3806	3727	6	yg	yg	PROPN
fnp-3806	3727	7	.	.	PROPN
fnp-3806	3727	8	tet	tet	NOUN
fnp-3806	3727	9	family	family	NOUN
fnp-3806	3727	10	proteins	protein	NOUN
fnp-3806	3727	11	and	and	CCONJ
fnp-3806	3727	12	5hydroxymethylcytosine	5hydroxymethylcytosine	NUM
fnp-3806	3727	13	in	in	ADP
fnp-3806	3727	14	development	development	NOUN
fnp-3806	3727	15	and	and	CCONJ
fnp-3806	3727	16	disease	disease	NOUN
fnp-3806	3727	17	.	.	PUNCT
fnp-3806	3728	1	development	development	PROPN
fnp-3806	3728	2	2012;139:1895–1902	2012;139:1895–1902	PROPN
fnp-3806	3728	3	.	.	PUNCT
fnp-3806	3729	1	https://doi.org/10.1242/dev.070771	https://doi.org/10.1242/dev.070771	PROPN
fnp-3806	3729	2	irier	irier	NOUN
fnp-3806	3729	3	ha	ha	INTJ
fnp-3806	3729	4	,	,	PUNCT
fnp-3806	3729	5	jin	jin	NOUN
fnp-3806	3729	6	p.	p.	NOUN
fnp-3806	3729	7	dynamics	dynamic	NOUN
fnp-3806	3729	8	of	of	ADP
fnp-3806	3729	9	dna	dna	PROPN
fnp-3806	3729	10	methylation	methylation	NOUN
fnp-3806	3729	11	in	in	ADP
fnp-3806	3729	12	aging	aging	NOUN
fnp-3806	3729	13	and	and	CCONJ
fnp-3806	3729	14	alzheimer	alzheimer	PROPN
fnp-3806	3729	15	’s	’s	PART
fnp-3806	3729	16	disease	disease	NOUN
fnp-3806	3729	17	.	.	PUNCT
fnp-3806	3730	1	dna	dna	PROPN
fnp-3806	3730	2	cell	cell	NOUN
fnp-3806	3730	3	biol	biol	NOUN
fnp-3806	3730	4	2012;31	2012;31	NUM
fnp-3806	3730	5	:	:	PUNCT
fnp-3806	3730	6	s42	s42	PROPN
fnp-3806	3730	7	–	–	PUNCT
fnp-3806	3730	8	s48	s48	NOUN
fnp-3806	3730	9	.	.	PUNCT
fnp-3806	3731	1	https://doi.org/10.1089/dna.2011.1565	https://doi.org/10.1089/dna.2011.1565	PROPN
fnp-3806	3731	2	wu	wu	PROPN
fnp-3806	3732	1	x	x	PROPN
fnp-3806	3732	2	,	,	PUNCT
fnp-3806	3732	3	zhang	zhang	PROPN
fnp-3806	3732	4	y.	y.	PROPN
fnp-3806	3732	5	tet	tet	PROPN
fnp-3806	3732	6	-	-	PUNCT
fnp-3806	3732	7	mediated	mediate	VERB
fnp-3806	3732	8	active	active	ADJ
fnp-3806	3732	9	dna	dna	NOUN
fnp-3806	3732	10	demethylation	demethylation	NOUN
fnp-3806	3732	11	:	:	PUNCT
fnp-3806	3732	12	mechanism	mechanism	NOUN
fnp-3806	3732	13	,	,	PUNCT
fnp-3806	3732	14	function	function	NOUN
fnp-3806	3732	15	and	and	CCONJ
fnp-3806	3732	16	beyond	beyond	ADP
fnp-3806	3732	17	.	.	PUNCT
fnp-3806	3733	1	nat	nat	PROPN
fnp-3806	3733	2	rev	rev	PROPN
fnp-3806	3733	3	genet	genet	PROPN
fnp-3806	3733	4	2017;18:517	2017;18:517	PROPN
fnp-3806	3733	5	-	-	PUNCT
fnp-3806	3733	6	534	534	NUM
fnp-3806	3733	7	.	.	PUNCT
fnp-3806	3734	1	https://doi.org/10.1038/nrg.2017.33	https://doi.org/10.1038/nrg.2017.33	PROPN
fnp-3806	3734	2	siegmund	siegmund	PROPN
fnp-3806	3734	3	kd	kd	PROPN
fnp-3806	3734	4	,	,	PUNCT
fnp-3806	3734	5	connor	connor	PROPN
fnp-3806	3734	6	cm	cm	PROPN
fnp-3806	3734	7	,	,	PUNCT
fnp-3806	3734	8	campan	campan	VERB
fnp-3806	3734	9	m	m	PROPN
fnp-3806	3734	10	,	,	PUNCT
fnp-3806	3734	11	et	et	PROPN
fnp-3806	3734	12	al	al	PROPN
fnp-3806	3734	13	.	.	PROPN
fnp-3806	3735	1	dna	dna	PROPN
fnp-3806	3735	2	methylation	methylation	NOUN
fnp-3806	3735	3	in	in	ADP
fnp-3806	3735	4	the	the	DET
fnp-3806	3735	5	human	human	ADJ
fnp-3806	3735	6	cerebral	cerebral	ADJ
fnp-3806	3735	7	cortex	cortex	NOUN
fnp-3806	3735	8	is	be	AUX
fnp-3806	3735	9	dynamically	dynamically	ADV
fnp-3806	3735	10	regulated	regulate	VERB
fnp-3806	3735	11	throughout	throughout	ADP
fnp-3806	3735	12	the	the	DET
fnp-3806	3735	13	life	life	NOUN
fnp-3806	3735	14	span	span	NOUN
fnp-3806	3735	15	and	and	CCONJ
fnp-3806	3735	16	involves	involve	VERB
fnp-3806	3735	17	differentiated	differentiated	ADJ
fnp-3806	3735	18	neurons	neuron	NOUN
fnp-3806	3735	19	.	.	PUNCT
fnp-3806	3736	1	plos	plos	PROPN
fnp-3806	3736	2	one	one	NUM
fnp-3806	3736	3	2007	2007	NUM
fnp-3806	3736	4	;	;	PUNCT
fnp-3806	3736	5	2	2	NUM
fnp-3806	3736	6	:	:	PUNCT
fnp-3806	3736	7	e895	e895	NUM
fnp-3806	3736	8	.	.	PUNCT
fnp-3806	3737	1	https://doi.org/10.1371/journal.pone.0000895	https://doi.org/10.1371/journal.pone.0000895	PROPN
fnp-3806	3737	2	wang	wang	PROPN
fnp-3806	3737	3	sc	sc	PROPN
fnp-3806	3737	4	,	,	PUNCT
fnp-3806	3737	5	oeize	oeize	NOUN
fnp-3806	3737	6	b	b	NUM
fnp-3806	3737	7	,	,	PUNCT
fnp-3806	3737	8	schumacher	schumacher	PROPN
fnp-3806	3737	9	a.	a.	NOUN
fnp-3806	3737	10	age	age	NOUN
fnp-3806	3737	11	-	-	PUNCT
fnp-3806	3737	12	specific	specific	ADJ
fnp-3806	3737	13	epigenetic	epigenetic	ADJ
fnp-3806	3737	14	drift	drift	NOUN
fnp-3806	3737	15	in	in	ADP
fnp-3806	3737	16	late	late	ADJ
fnp-3806	3737	17	-	-	PUNCT
fnp-3806	3737	18	onset	onset	NOUN
fnp-3806	3737	19	alzheimer	alzheimer	PROPN
fnp-3806	3737	20	’s	’s	PART
fnp-3806	3737	21	disease	disease	NOUN
fnp-3806	3737	22	.	.	PUNCT
fnp-3806	3738	1	plos	plos	PROPN
fnp-3806	3738	2	one	one	NUM
fnp-3806	3738	3	2008	2008	NUM
fnp-3806	3738	4	;	;	PUNCT
fnp-3806	3738	5	2008;3	2008;3	NUM
fnp-3806	3738	6	:	:	PUNCT
fnp-3806	3738	7	e2698	e2698	ADJ
fnp-3806	3738	8	.	.	PUNCT
fnp-3806	3739	1	https://doi.org/10.1371/journal.pone.0002698	https://doi.org/10.1371/journal.pone.0002698	NOUN
fnp-3806	3739	2	mastroeni	mastroeni	PROPN
fnp-3806	3739	3	d	d	PROPN
fnp-3806	3739	4	,	,	PUNCT
fnp-3806	3739	5	grover	grover	PROPN
fnp-3806	3739	6	a	a	PROPN
fnp-3806	3739	7	,	,	PUNCT
fnp-3806	3739	8	delvaux	delvaux	PROPN
fnp-3806	3739	9	e	e	NOUN
fnp-3806	3739	10	,	,	PUNCT
fnp-3806	3739	11	et	et	PROPN
fnp-3806	3739	12	al	al	PROPN
fnp-3806	3739	13	.	.	PUNCT
fnp-3806	3739	14	epigenetic	epigenetic	ADJ
fnp-3806	3739	15	mechanisms	mechanism	NOUN
fnp-3806	3739	16	in	in	ADP
fnp-3806	3739	17	alzheimer	alzheimer	PROPN
fnp-3806	3739	18	’s	’s	PART
fnp-3806	3739	19	disease	disease	NOUN
fnp-3806	3739	20	.	.	PUNCT
fnp-3806	3740	1	neurobiol	neurobiol	PROPN
fnp-3806	3740	2	aging	age	VERB
fnp-3806	3740	3	2011;32:1161	2011;32:1161	PROPN
fnp-3806	3740	4	-	-	SYM
fnp-3806	3740	5	1180	1180	NUM
fnp-3806	3740	6	.	.	PUNCT
fnp-3806	3741	1	https://doi.org/10.1016/j.neurobiolaging.2010.08.017	https://doi.org/10.1016/j.neurobiolaging.2010.08.017	PROPN
fnp-3806	3741	2	bakulski	bakulski	PROPN
fnp-3806	3741	3	km	km	PROPN
fnp-3806	3741	4	,	,	PUNCT
fnp-3806	3741	5	dolinoy	dolinoy	ADV
fnp-3806	3741	6	dc	dc	PROPN
fnp-3806	3741	7	,	,	PUNCT
fnp-3806	3741	8	sartor	sartor	PROPN
fnp-3806	3741	9	ma	ma	PROPN
fnp-3806	3741	10	et	et	PROPN
fnp-3806	3741	11	al	al	PROPN
fnp-3806	3741	12	.	.	PUNCT
fnp-3806	3741	13	genome	genome	NOUN
fnp-3806	3741	14	-	-	PUNCT
fnp-3806	3741	15	wide	wide	ADJ
fnp-3806	3741	16	dna	dna	PROPN
fnp-3806	3741	17	methylation	methylation	NOUN
fnp-3806	3741	18	differences	difference	NOUN
fnp-3806	3741	19	between	between	ADP
fnp-3806	3741	20	late	late	ADJ
fnp-3806	3741	21	-	-	PUNCT
fnp-3806	3741	22	onset	onset	NOUN
fnp-3806	3741	23	alzheimer	alzheimer	NOUN
fnp-3806	3741	24	’s	’s	PART
fnp-3806	3741	25	disease	disease	NOUN
fnp-3806	3741	26	and	and	CCONJ
fnp-3806	3741	27	cognitively	cognitively	ADV
fnp-3806	3741	28	normal	normal	ADJ
fnp-3806	3741	29	controls	control	NOUN
fnp-3806	3741	30	in	in	ADP
fnp-3806	3741	31	human	human	ADJ
fnp-3806	3741	32	frontal	frontal	ADJ
fnp-3806	3741	33	cortex	cortex	NOUN
fnp-3806	3741	34	.	.	PUNCT
fnp-3806	3742	1	j	j	PROPN
fnp-3806	3742	2	alzheimers	alzheimers	PROPN
fnp-3806	3742	3	dis	dis	PROPN
fnp-3806	3742	4	2012;29:571	2012;29:571	NUM
fnp-3806	3742	5	-	-	SYM
fnp-3806	3742	6	588	588	NUM
fnp-3806	3742	7	.	.	PUNCT
fnp-3806	3742	8	https://doi.org/10.3233/jad-2012-111223	https://doi.org/10.3233/jad-2012-111223	PROPN
fnp-3806	3742	9	watson	watson	PROPN
fnp-3806	3742	10	ct	ct	PROPN
fnp-3806	3742	11	,	,	PUNCT
fnp-3806	3742	12	roussos	roussos	PROPN
fnp-3806	3742	13	p	p	PROPN
fnp-3806	3742	14	,	,	PUNCT
fnp-3806	3742	15	garg	garg	NOUN
fnp-3806	3742	16	p	p	X
fnp-3806	3742	17	,	,	PUNCT
fnp-3806	3742	18	et	et	PROPN
fnp-3806	3742	19	al	al	PROPN
fnp-3806	3742	20	.	.	PUNCT
fnp-3806	3742	21	genome	genome	NOUN
fnp-3806	3742	22	-	-	PUNCT
fnp-3806	3742	23	wide	wide	ADJ
fnp-3806	3742	24	dna	dna	PROPN
fnp-3806	3742	25	methylation	methylation	NOUN
fnp-3806	3742	26	profiling	profiling	NOUN
fnp-3806	3742	27	in	in	ADP
fnp-3806	3742	28	the	the	DET
fnp-3806	3742	29	superior	superior	ADJ
fnp-3806	3742	30	temporal	temporal	ADJ
fnp-3806	3742	31	gyrus	gyrus	NOUN
fnp-3806	3742	32	reveals	reveal	VERB
fnp-3806	3742	33	epigenetic	epigenetic	ADJ
fnp-3806	3742	34	signatures	signature	NOUN
fnp-3806	3742	35	associated	associate	VERB
fnp-3806	3742	36	with	with	ADP
fnp-3806	3742	37	alzheimer	alzheimer	PROPN
fnp-3806	3742	38	’s	’s	PART
fnp-3806	3742	39	disease	disease	NOUN
fnp-3806	3742	40	.	.	PUNCT
fnp-3806	3743	1	genome	genome	NOUN
fnp-3806	3743	2	med	me	VERB
fnp-3806	3743	3	2016;8:5	2016;8:5	NUM
fnp-3806	3743	4	.	.	PUNCT
fnp-3806	3744	1	https://doi.org/10.1186/s13073-015-0258-8	https://doi.org/10.1186/s13073-015-0258-8	NUM
fnp-3806	3744	2	smith	smith	PROPN
fnp-3806	3744	3	ar	ar	PROPN
fnp-3806	3744	4	,	,	PUNCT
fnp-3806	3744	5	smith	smith	PROPN
fnp-3806	3744	6	rg	rg	PROPN
fnp-3806	3744	7	,	,	PUNCT
fnp-3806	3744	8	pishva	pishva	NOUN
fnp-3806	3744	9	e	e	NOUN
fnp-3806	3744	10	,	,	PUNCT
fnp-3806	3744	11	et	et	PROPN
fnp-3806	3744	12	al	al	PROPN
fnp-3806	3744	13	.	.	PROPN
fnp-3806	3745	1	parallel	parallel	ADJ
fnp-3806	3745	2	profiling	profiling	NOUN
fnp-3806	3745	3	of	of	ADP
fnp-3806	3745	4	dna	dna	PROPN
fnp-3806	3745	5	methylation	methylation	NOUN
fnp-3806	3745	6	and	and	CCONJ
fnp-3806	3745	7	hydroxymethylation	hydroxymethylation	NOUN
fnp-3806	3745	8	highlights	highlight	NOUN
fnp-3806	3745	9	neuropathology	neuropathology	NOUN
fnp-3806	3745	10	-	-	PUNCT
fnp-3806	3745	11	associated	associate	VERB
fnp-3806	3745	12	epigenetic	epigenetic	ADJ
fnp-3806	3745	13	variation	variation	NOUN
fnp-3806	3745	14	in	in	ADP
fnp-3806	3745	15	alzheimer	alzheimer	PROPN
fnp-3806	3745	16	's	's	PART
fnp-3806	3745	17	disease	disease	NOUN
fnp-3806	3745	18	.	.	PUNCT
fnp-3806	3746	1	clin	clin	PROPN
fnp-3806	3746	2	epigenetics	epigenetics	PROPN
fnp-3806	3746	3	2019;11:52	2019;11:52	NUM
fnp-3806	3746	4	.	.	PUNCT
fnp-3806	3747	1	https://doi.org/10.1186/s13148-019-0636-y	https://doi.org/10.1186/s13148-019-0636-y	PROPN
fnp-3806	3747	2	sanchez	sanchez	PROPN
fnp-3806	3747	3	-	-	PUNCT
fnp-3806	3747	4	mut	mut	PROPN
fnp-3806	3747	5	jv	jv	PROPN
fnp-3806	3747	6	,	,	PUNCT
fnp-3806	3747	7	aso	aso	PROPN
fnp-3806	3747	8	e	e	PROPN
fnp-3806	3747	9	,	,	PUNCT
fnp-3806	3747	10	panayotis	panayotis	PROPN
fnp-3806	3747	11	n	n	CCONJ
fnp-3806	3747	12	,	,	PUNCT
fnp-3806	3747	13	et	et	PROPN
fnp-3806	3747	14	al	al	PROPN
fnp-3806	3747	15	.	.	PROPN
fnp-3806	3747	16	dna	dna	PROPN
fnp-3806	3747	17	methylation	methylation	NOUN
fnp-3806	3747	18	map	map	NOUN
fnp-3806	3747	19	of	of	ADP
fnp-3806	3747	20	mouse	mouse	NOUN
fnp-3806	3747	21	and	and	CCONJ
fnp-3806	3747	22	human	human	ADJ
fnp-3806	3747	23	brain	brain	NOUN
fnp-3806	3747	24	identifies	identify	VERB
fnp-3806	3747	25	target	target	NOUN
fnp-3806	3747	26	genes	gene	NOUN
fnp-3806	3747	27	in	in	ADP
fnp-3806	3747	28	alzheimer	alzheimer	PROPN
fnp-3806	3747	29	’s	’s	PART
fnp-3806	3747	30	disease	disease	NOUN
fnp-3806	3747	31	.	.	PUNCT
fnp-3806	3748	1	brain	brain	NOUN
fnp-3806	3748	2	2013;136:3018–3027	2013;136:3018–3027	NUM
fnp-3806	3748	3	.	.	PUNCT
fnp-3806	3749	1	https://doi.org/10.1093/brain/awt237	https://doi.org/10.1093/brain/awt237	PROPN
fnp-3806	3749	2	sanchez	sanchez	PROPN
fnp-3806	3749	3	-	-	PUNCT
fnp-3806	3749	4	mut	mut	PROPN
fnp-3806	3749	5	jv	jv	PROPN
fnp-3806	3749	6	,	,	PUNCT
fnp-3806	3749	7	heyn	heyn	NOUN
fnp-3806	3749	8	h	h	NOUN
fnp-3806	3749	9	,	,	PUNCT
fnp-3806	3749	10	vidal	vidal	PROPN
fnp-3806	3749	11	e	e	PROPN
fnp-3806	3749	12	,	,	PUNCT
fnp-3806	3749	13	et	et	PROPN
fnp-3806	3749	14	al	al	PROPN
fnp-3806	3749	15	.	.	PROPN
fnp-3806	3750	1	human	human	PROPN
fnp-3806	3750	2	dna	dna	PROPN
fnp-3806	3750	3	methylomes	methylome	NOUN
fnp-3806	3750	4	of	of	ADP
fnp-3806	3750	5	neurodegenerative	neurodegenerative	ADJ
fnp-3806	3750	6	diseases	disease	NOUN
fnp-3806	3750	7	show	show	VERB
fnp-3806	3750	8	common	common	ADJ
fnp-3806	3750	9	epigenomic	epigenomic	ADJ
fnp-3806	3750	10	patterns	pattern	NOUN
fnp-3806	3750	11	.	.	PUNCT
fnp-3806	3751	1	transl	transl	PROPN
fnp-3806	3751	2	psychiatry	psychiatry	NOUN
fnp-3806	3751	3	2016;6	2016;6	PROPN
fnp-3806	3751	4	:	:	PUNCT
fnp-3806	3751	5	e718	e718	PROPN
fnp-3806	3751	6	.	.	PROPN
fnp-3806	3751	7	https://doi.org/10.1038/tp.2015.214	https://doi.org/10.1038/tp.2015.214	PROPN
fnp-3806	3751	8	rao	rao	PROPN
fnp-3806	3751	9	js	js	PROPN
fnp-3806	3751	10	,	,	PUNCT
fnp-3806	3751	11	keleshian	keleshian	PROPN
fnp-3806	3751	12	vl	vl	PROPN
fnp-3806	3751	13	,	,	PUNCT
fnp-3806	3751	14	klein	klein	PROPN
fnp-3806	3751	15	s	s	PROPN
fnp-3806	3751	16	,	,	PUNCT
fnp-3806	3751	17	et	et	PROPN
fnp-3806	3751	18	al	al	PROPN
fnp-3806	3751	19	.	.	PUNCT
fnp-3806	3752	1	epigenetic	epigenetic	ADJ
fnp-3806	3752	2	modifications	modification	NOUN
fnp-3806	3752	3	in	in	ADP
fnp-3806	3752	4	frontal	frontal	ADJ
fnp-3806	3752	5	cortex	cortex	NOUN
fnp-3806	3752	6	from	from	ADP
fnp-3806	3752	7	alzheimer	alzheimer	PROPN
fnp-3806	3752	8	’s	’s	PART
fnp-3806	3752	9	disease	disease	NOUN
fnp-3806	3752	10	and	and	CCONJ
fnp-3806	3752	11	bipolar	bipolar	ADJ
fnp-3806	3752	12	disorder	disorder	NOUN
fnp-3806	3752	13	patients	patient	NOUN
fnp-3806	3752	14	.	.	PUNCT
fnp-3806	3753	1	transl	transl	PROPN
fnp-3806	3753	2	psychiatry	psychiatry	PROPN
fnp-3806	3753	3	2012;2	2012;2	NUM
fnp-3806	3753	4	:	:	PUNCT
fnp-3806	3754	1	e132	e132	PROPN
fnp-3806	3754	2	.	.	PUNCT
fnp-3806	3754	3	https://doi.org/10.1038/tp.2012.55	https://doi.org/10.1038/tp.2012.55	X
fnp-3806	3754	4	scarpa	scarpa	NOUN
fnp-3806	3754	5	s	s	NOUN
fnp-3806	3754	6	,	,	PUNCT
fnp-3806	3754	7	fuso	fuso	PROPN
fnp-3806	3754	8	a	a	X
fnp-3806	3754	9	,	,	PUNCT
fnp-3806	3754	10	d’anselmi	d’anselmi	PROPN
fnp-3806	3754	11	f	f	PROPN
fnp-3806	3754	12	,	,	PUNCT
fnp-3806	3754	13	et	et	PROPN
fnp-3806	3754	14	al	al	PROPN
fnp-3806	3754	15	.	.	PROPN
fnp-3806	3755	1	presenilin	presenilin	PROPN
fnp-3806	3755	2	1	1	NUM
fnp-3806	3755	3	gene	gene	NOUN
fnp-3806	3755	4	silencing	silence	VERB
fnp-3806	3755	5	by	by	ADP
fnp-3806	3755	6	s	s	NOUN
fnp-3806	3755	7	-	-	NOUN
fnp-3806	3755	8	adenosylmethionine	adenosylmethionine	NOUN
fnp-3806	3755	9	:	:	PUNCT
fnp-3806	3755	10	a	a	DET
fnp-3806	3755	11	treatment	treatment	NOUN
fnp-3806	3755	12	for	for	ADP
fnp-3806	3755	13	alzheimer	alzheimer	PROPN
fnp-3806	3755	14	disease	disease	NOUN
fnp-3806	3755	15	?	?	PUNCT
fnp-3806	3756	1	febs	febs	PROPN
fnp-3806	3756	2	lett	lett	PROPN
fnp-3806	3756	3	2003;541:145	2003;541:145	PROPN
fnp-3806	3756	4	-	-	SYM
fnp-3806	3756	5	148	148	NUM
fnp-3806	3756	6	.	.	PUNCT
fnp-3806	3757	1	https://doi.org/10.1016/s0014-5793(03)00277-1	https://doi.org/10.1016/s0014-5793(03)00277-1	PROPN
fnp-3806	3757	2	fuso	fuso	PROPN
fnp-3806	3757	3	a	a	X
fnp-3806	3757	4	,	,	PUNCT
fnp-3806	3757	5	seminara	seminara	ADJ
fnp-3806	3757	6	l	l	PROPN
fnp-3806	3757	7	,	,	PUNCT
fnp-3806	3757	8	cavallaro	cavallaro	PROPN
fnp-3806	3757	9	ra	ra	PROPN
fnp-3806	3757	10	,	,	PUNCT
fnp-3806	3757	11	et	et	PROPN
fnp-3806	3757	12	al	al	PROPN
fnp-3806	3757	13	.	.	PUNCT
fnp-3806	3757	14	s	s	X
fnp-3806	3757	15	-	-	PUNCT
fnp-3806	3757	16	adenosylmethionine	adenosylmethionine	NOUN
fnp-3806	3757	17	/	/	SYM
fnp-3806	3757	18	homocysteine	homocysteine	PROPN
fnp-3806	3757	19	cycle	cycle	NOUN
fnp-3806	3757	20	alterations	alteration	NOUN
fnp-3806	3757	21	modify	modify	VERB
fnp-3806	3757	22	dna	dna	PROPN
fnp-3806	3757	23	methylation	methylation	NOUN
fnp-3806	3757	24	status	status	NOUN
fnp-3806	3757	25	with	with	ADP
fnp-3806	3757	26	consequent	consequent	ADJ
fnp-3806	3757	27	deregulation	deregulation	NOUN
fnp-3806	3757	28	of	of	ADP
fnp-3806	3757	29	ps1	ps1	PROPN
fnp-3806	3757	30	and	and	CCONJ
fnp-3806	3757	31	bace	bace	PROPN
fnp-3806	3757	32	and	and	CCONJ
fnp-3806	3757	33	beta	beta	NOUN
fnp-3806	3757	34	-	-	PUNCT
fnp-3806	3757	35	amyloid	amyloid	NOUN
fnp-3806	3757	36	production	production	NOUN
fnp-3806	3757	37	.	.	PUNCT
fnp-3806	3758	1	mol	mol	ADP
fnp-3806	3758	2	cell	cell	NOUN
fnp-3806	3758	3	neurosci	neurosci	NOUN
fnp-3806	3758	4	2005;28:195–204	2005;28:195–204	NUM
fnp-3806	3758	5	.	.	PUNCT
fnp-3806	3759	1	https://doi.org/10.1016/j.mcn.2004.09.007	https://doi.org/10.1016/j.mcn.2004.09.007	PROPN
fnp-3806	3759	2	monti	monti	PROPN
fnp-3806	3759	3	n	n	PROPN
fnp-3806	3759	4	,	,	PUNCT
fnp-3806	3759	5	cavallaro	cavallaro	PROPN
fnp-3806	3759	6	ra	ra	PROPN
fnp-3806	3759	7	,	,	PUNCT
fnp-3806	3759	8	stoccoro	stoccoro	VERB
fnp-3806	3759	9	a	a	PRON
fnp-3806	3759	10	,	,	PUNCT
fnp-3806	3760	1	et	et	PROPN
fnp-3806	3760	2	al	al	PROPN
fnp-3806	3760	3	.	.	PUNCT
fnp-3806	3760	4	cpg	cpg	PROPN
fnp-3806	3760	5	and	and	CCONJ
fnp-3806	3760	6	non	non	ADJ
fnp-3806	3760	7	-	-	ADJ
fnp-3806	3760	8	cpg	cpg	ADJ
fnp-3806	3760	9	presenilin1	presenilin1	PROPN
fnp-3806	3760	10	methylation	methylation	NOUN
fnp-3806	3760	11	pattern	pattern	NOUN
fnp-3806	3760	12	in	in	ADP
fnp-3806	3760	13	course	course	NOUN
fnp-3806	3760	14	of	of	ADP
fnp-3806	3760	15	neurodevelopment	neurodevelopment	ADJ
fnp-3806	3760	16	and	and	CCONJ
fnp-3806	3760	17	neurodegeneration	neurodegeneration	NOUN
fnp-3806	3760	18	is	be	AUX
fnp-3806	3760	19	associated	associate	VERB
fnp-3806	3760	20	with	with	ADP
fnp-3806	3760	21	gene	gene	NOUN
fnp-3806	3760	22	expression	expression	NOUN
fnp-3806	3760	23	in	in	ADP
fnp-3806	3760	24	human	human	ADJ
fnp-3806	3760	25	and	and	CCONJ
fnp-3806	3760	26	murine	murine	ADJ
fnp-3806	3760	27	brain	brain	NOUN
fnp-3806	3760	28	.	.	PUNCT
fnp-3806	3761	1	epigenetics	epigenetic	NOUN
fnp-3806	3761	2	2020;15	2020;15	NOUN
fnp-3806	3761	3	:	:	PUNCT
fnp-3806	3761	4	781	781	NUM
fnp-3806	3761	5	-	-	SYM
fnp-3806	3761	6	799	799	NUM
fnp-3806	3761	7	.	.	PUNCT
fnp-3806	3762	1	https://doi.org/10.1080/15592294.2020.1722917	https://doi.org/10.1080/15592294.2020.1722917	PROPN
fnp-3806	3762	2	sontag	sontag	PROPN
fnp-3806	3762	3	e	e	PROPN
fnp-3806	3762	4	,	,	PUNCT
fnp-3806	3762	5	nunbhakdi	nunbhakdi	PROPN
fnp-3806	3762	6	-	-	PUNCT
fnp-3806	3762	7	craig	craig	PROPN
fnp-3806	3762	8	v	v	PROPN
fnp-3806	3762	9	,	,	PUNCT
fnp-3806	3762	10	sontag	sontag	PROPN
fnp-3806	3762	11	j	j	PROPN
fnp-3806	3762	12	-	-	PROPN
fnp-3806	3762	13	m	m	PROPN
fnp-3806	3762	14	,	,	PUNCT
fnp-3806	3762	15	et	et	PROPN
fnp-3806	3762	16	al	al	PROPN
fnp-3806	3762	17	.	.	PUNCT
fnp-3806	3763	1	protein	protein	NOUN
fnp-3806	3763	2	phosphatase	phosphatase	NOUN
fnp-3806	3763	3	2a	2a	NUM
fnp-3806	3763	4	methyltransferase	methyltransferase	NOUN
fnp-3806	3763	5	links	link	NOUN
fnp-3806	3763	6	homocysteine	homocysteine	VERB
fnp-3806	3763	7	metabolism	metabolism	NOUN
fnp-3806	3763	8	with	with	ADP
fnp-3806	3763	9	tau	tau	PROPN
fnp-3806	3763	10	and	and	CCONJ
fnp-3806	3763	11	amyloid	amyloid	NOUN
fnp-3806	3763	12	precursor	precursor	NOUN
fnp-3806	3763	13	protein	protein	NOUN
fnp-3806	3763	14	regulation	regulation	NOUN
fnp-3806	3763	15	.	.	PUNCT
fnp-3806	3764	1	j	j	PROPN
fnp-3806	3764	2	neurosci	neurosci	PROPN
fnp-3806	3764	3	2007	2007	NUM
fnp-3806	3764	4	;	;	PUNCT
fnp-3806	3764	5	27:2751	27:2751	NUM
fnp-3806	3764	6	-	-	SYM
fnp-3806	3764	7	2759	2759	NUM
fnp-3806	3764	8	.	.	PUNCT
fnp-3806	3765	1	https://doi.org/10.1523/jneurosci.3316-06.2007	https://doi.org/10.1523/jneurosci.3316-06.2007	PROPN
fnp-3806	3765	2	zhou	zhou	PROPN
fnp-3806	3765	3	xw	xw	PROPN
fnp-3806	3765	4	,	,	PUNCT
fnp-3806	3765	5	gustafsson	gustafsson	PROPN
fnp-3806	3765	6	ja	ja	PROPN
fnp-3806	3765	7	,	,	PUNCT
fnp-3806	3765	8	tanila	tanila	PROPN
fnp-3806	3765	9	h	h	NOUN
fnp-3806	3765	10	,	,	PUNCT
fnp-3806	3765	11	et	et	PROPN
fnp-3806	3765	12	al	al	PROPN
fnp-3806	3765	13	.	.	PUNCT
fnp-3806	3766	1	tau	tau	PROPN
fnp-3806	3766	2	hyperphosphorylation	hyperphosphorylation	NOUN
fnp-3806	3766	3	correlates	correlate	VERB
fnp-3806	3766	4	with	with	ADP
fnp-3806	3766	5	reduced	reduced	ADJ
fnp-3806	3766	6	methylation	methylation	NOUN
fnp-3806	3766	7	of	of	ADP
fnp-3806	3766	8	protein	protein	NOUN
fnp-3806	3766	9	phosphatase	phosphatase	NOUN
fnp-3806	3766	10	2a	2a	NUM
fnp-3806	3766	11	.	.	PUNCT
fnp-3806	3767	1	neurobiol	neurobiol	PROPN
fnp-3806	3767	2	dis	dis	PROPN
fnp-3806	3767	3	2008;31:386	2008;31:386	PROPN
fnp-3806	3767	4	-	-	SYM
fnp-3806	3767	5	394	394	NUM
fnp-3806	3767	6	.	.	PUNCT
fnp-3806	3768	1	https://doi.org/10.1016/j.nbd.2008.05.013	https://doi.org/10.1016/j.nbd.2008.05.013	PROPN
fnp-3806	3768	2	bernstein	bernstein	PROPN
fnp-3806	3768	3	ai	ai	PROPN
fnp-3806	3768	4	,	,	PUNCT
fnp-3806	3768	5	lin	lin	PROPN
fnp-3806	3768	6	y	y	PROPN
fnp-3806	3768	7	,	,	PUNCT
fnp-3806	3768	8	street	street	PROPN
fnp-3806	3768	9	rc	rc	PROPN
fnp-3806	3768	10	,	,	PUNCT
fnp-3806	3768	11	et	et	PROPN
fnp-3806	3768	12	al	al	PROPN
fnp-3806	3768	13	.	.	PROPN
fnp-3806	3769	1	5	5	NUM
fnp-3806	3769	2	-	-	PUNCT
fnp-3806	3769	3	hydroxymethylation	hydroxymethylation	NOUN
fnp-3806	3769	4	associated	associate	VERB
fnp-3806	3769	5	epigenetic	epigenetic	ADJ
fnp-3806	3769	6	modifiers	modifier	NOUN
fnp-3806	3769	7	of	of	ADP
fnp-3806	3769	8	alzheimer	alzheimer	PROPN
fnp-3806	3769	9	’s	’s	PART
fnp-3806	3769	10	disease	disease	NOUN
fnp-3806	3769	11	modulates	modulate	VERB
fnp-3806	3769	12	tau	tau	PROPN
fnp-3806	3769	13	induced	induce	VERB
fnp-3806	3769	14	neurotoxicity	neurotoxicity	NOUN
fnp-3806	3769	15	.	.	PUNCT
fnp-3806	3770	1	hum	hum	PROPN
fnp-3806	3770	2	mol	mol	ADP
fnp-3806	3770	3	genet	genet	PROPN
fnp-3806	3770	4	2016;25:2437	2016;25:2437	NUM
fnp-3806	3770	5	-	-	SYM
fnp-3806	3770	6	2450	2450	NUM
fnp-3806	3770	7	.	.	PUNCT
fnp-3806	3771	1	https://doi.org/10.1093/hmg/ddw109	https://doi.org/10.1093/hmg/ddw109	VERB
fnp-3806	3771	2	pietrzak	pietrzak	NOUN
fnp-3806	3771	3	m	m	PROPN
fnp-3806	3771	4	,	,	PUNCT
fnp-3806	3771	5	rempala	rempala	PROPN
fnp-3806	3771	6	g	g	PROPN
fnp-3806	3771	7	,	,	PUNCT
fnp-3806	3771	8	nelson	nelson	PROPN
fnp-3806	3771	9	pt	pt	PROPN
fnp-3806	3771	10	,	,	PUNCT
fnp-3806	3771	11	et	et	PROPN
fnp-3806	3771	12	al	al	PROPN
fnp-3806	3771	13	.	.	PUNCT
fnp-3806	3771	14	epigenetic	epigenetic	ADJ
fnp-3806	3771	15	silencing	silencing	NOUN
fnp-3806	3771	16	of	of	ADP
fnp-3806	3771	17	nucleolar	nucleolar	PROPN
fnp-3806	3771	18	rrna	rrna	PROPN
fnp-3806	3771	19	genes	gene	NOUN
fnp-3806	3771	20	in	in	ADP
fnp-3806	3771	21	alzheimer	alzheimer	PROPN
fnp-3806	3771	22	's	's	PART
fnp-3806	3771	23	disease	disease	NOUN
fnp-3806	3771	24	.	.	PUNCT
fnp-3806	3772	1	plos	plos	PROPN
fnp-3806	3772	2	one	one	NUM
fnp-3806	3772	3	2011;6	2011;6	NUM
fnp-3806	3772	4	:	:	PUNCT
fnp-3806	3772	5	e22585	e22585	NUM
fnp-3806	3772	6	.	.	PUNCT
fnp-3806	3773	1	https://doi.org/10.1371/journal.pone.0022585	https://doi.org/10.1371/journal.pone.0022585	PROPN
fnp-3806	3773	2	nagata	nagata	PROPN
fnp-3806	3773	3	t	t	PROPN
fnp-3806	3773	4	,	,	PUNCT
fnp-3806	3773	5	kobayashi	kobayashi	PROPN
fnp-3806	3773	6	n	n	CCONJ
fnp-3806	3773	7	,	,	PUNCT
fnp-3806	3773	8	ishii	ishii	PROPN
fnp-3806	3773	9	j	j	PROPN
fnp-3806	3773	10	,	,	PUNCT
fnp-3806	3773	11	et	et	PROPN
fnp-3806	3773	12	al	al	PROPN
fnp-3806	3773	13	.	.	PROPN
fnp-3806	3773	14	association	association	PROPN
fnp-3806	3773	15	between	between	ADP
fnp-3806	3773	16	dna	dna	PROPN
fnp-3806	3773	17	methylation	methylation	NOUN
fnp-3806	3773	18	of	of	ADP
fnp-3806	3773	19	the	the	DET
fnp-3806	3773	20	bdnf	bdnf	ADJ
fnp-3806	3773	21	promoter	promoter	NOUN
fnp-3806	3773	22	region	region	NOUN
fnp-3806	3773	23	and	and	CCONJ
fnp-3806	3773	24	clinical	clinical	ADJ
fnp-3806	3773	25	presentation	presentation	NOUN
fnp-3806	3773	26	in	in	ADP
fnp-3806	3773	27	alzheimer	alzheimer	PROPN
fnp-3806	3773	28	's	's	PART
fnp-3806	3773	29	disease	disease	NOUN
fnp-3806	3773	30	.	.	PUNCT
fnp-3806	3774	1	dement	dement	PROPN
fnp-3806	3774	2	geriatr	geriatr	PROPN
fnp-3806	3774	3	cogn	cogn	VERB
fnp-3806	3774	4	dis	dis	PROPN
fnp-3806	3774	5	extra	extra	ADJ
fnp-3806	3774	6	2015;5:64	2015;5:64	PROPN
fnp-3806	3774	7	-	-	PUNCT
fnp-3806	3774	8	73	73	NUM
fnp-3806	3774	9	.	.	PUNCT
fnp-3806	3775	1	https://doi.org/10.1159/000375367	https://doi.org/10.1159/000375367	X
fnp-3806	3775	2	wilson	wilson	PROPN
fnp-3806	3775	3	ag	ag	PROPN
fnp-3806	3775	4	.	.	PROPN
fnp-3806	3775	5	epigenetic	epigenetic	ADJ
fnp-3806	3775	6	regulation	regulation	NOUN
fnp-3806	3775	7	of	of	ADP
fnp-3806	3775	8	gene	gene	NOUN
fnp-3806	3775	9	expression	expression	NOUN
fnp-3806	3775	10	in	in	ADP
fnp-3806	3775	11	the	the	DET
fnp-3806	3775	12	inflammatory	inflammatory	ADJ
fnp-3806	3775	13	response	response	NOUN
fnp-3806	3775	14	and	and	CCONJ
fnp-3806	3775	15	relevance	relevance	NOUN
fnp-3806	3775	16	to	to	ADP
fnp-3806	3775	17	common	common	ADJ
fnp-3806	3775	18	diseases	disease	NOUN
fnp-3806	3775	19	.	.	PUNCT
fnp-3806	3776	1	j	j	PROPN
fnp-3806	3776	2	periodontol	periodontol	NOUN
fnp-3806	3776	3	2008;79:1514	2008;79:1514	PROPN
fnp-3806	3776	4	-	-	SYM
fnp-3806	3776	5	1519	1519	NUM
fnp-3806	3776	6	.	.	PUNCT
fnp-3806	3777	1	https://doi.org/10.1902/jop.2008.080172	https://doi.org/10.1902/jop.2008.080172	PROPN
fnp-3806	3777	2	smith	smith	PROPN
fnp-3806	3777	3	ar	ar	PROPN
fnp-3806	3777	4	,	,	PUNCT
fnp-3806	3777	5	smith	smith	PROPN
fnp-3806	3777	6	rg	rg	PROPN
fnp-3806	3777	7	,	,	PUNCT
fnp-3806	3777	8	condliffe	condliffe	PROPN
fnp-3806	3777	9	d	d	PROPN
fnp-3806	3777	10	,	,	PUNCT
fnp-3806	3777	11	et	et	PROPN
fnp-3806	3777	12	al	al	PROPN
fnp-3806	3777	13	.	.	PROPN
fnp-3806	3777	14	increased	increase	VERB
fnp-3806	3777	15	dna	dna	PROPN
fnp-3806	3777	16	methylation	methylation	NOUN
fnp-3806	3777	17	near	near	ADP
fnp-3806	3777	18	trem2	trem2	NOUN
fnp-3806	3777	19	is	be	AUX
fnp-3806	3777	20	consistently	consistently	ADV
fnp-3806	3777	21	seen	see	VERB
fnp-3806	3777	22	in	in	ADP
fnp-3806	3777	23	the	the	DET
fnp-3806	3777	24	superior	superior	ADJ
fnp-3806	3777	25	temporal	temporal	ADJ
fnp-3806	3777	26	gyrus	gyrus	NOUN
fnp-3806	3777	27	in	in	ADP
fnp-3806	3777	28	alzheimer	alzheimer	PROPN
fnp-3806	3777	29	’s	’s	PART
fnp-3806	3777	30	disease	disease	NOUN
fnp-3806	3777	31	brain	brain	NOUN
fnp-3806	3777	32	.	.	PUNCT
fnp-3806	3778	1	neurobiol	neurobiol	PROPN
fnp-3806	3778	2	aging	age	VERB
fnp-3806	3778	3	2016;47:35	2016;47:35	NUM
fnp-3806	3778	4	-	-	SYM
fnp-3806	3778	5	40	40	NUM
fnp-3806	3778	6	.	.	PUNCT
fnp-3806	3779	1	https://doi.org/10.1016/j.neurobiolaging.2016.07.008	https://doi.org/10.1016/j.neurobiolaging.2016.07.008	PROPN
fnp-3806	3779	2	nuutinen	nuutinen	PROPN
fnp-3806	3779	3	t	t	PROPN
fnp-3806	3779	4	,	,	PUNCT
fnp-3806	3779	5	suuronen	suuronen	PROPN
fnp-3806	3779	6	t	t	PROPN
fnp-3806	3779	7	,	,	PUNCT
fnp-3806	3779	8	kyrylenko	kyrylenko	PROPN
fnp-3806	3779	9	s	s	PROPN
fnp-3806	3779	10	,	,	PUNCT
fnp-3806	3779	11	et	et	PROPN
fnp-3806	3779	12	al	al	PROPN
fnp-3806	3779	13	.	.	PROPN
fnp-3806	3779	14	induction	induction	NOUN
fnp-3806	3779	15	of	of	ADP
fnp-3806	3779	16	clusterin	clusterin	NOUN
fnp-3806	3779	17	/	/	SYM
fnp-3806	3779	18	apoj	apoj	NOUN
fnp-3806	3779	19	expression	expression	NOUN
fnp-3806	3779	20	by	by	ADP
fnp-3806	3779	21	histone	histone	NOUN
fnp-3806	3779	22	deacetylase	deacetylase	VERB
fnp-3806	3779	23	inhibitors	inhibitor	NOUN
fnp-3806	3779	24	in	in	ADP
fnp-3806	3779	25	neural	neural	ADJ
fnp-3806	3779	26	cells	cell	NOUN
fnp-3806	3779	27	.	.	PUNCT
fnp-3806	3780	1	neurochem	neurochem	PROPN
fnp-3806	3780	2	int	int	VERB
fnp-3806	3780	3	2005;647:528	2005;647:528	NUM
fnp-3806	3780	4	-	-	SYM
fnp-3806	3780	5	538	538	NUM
fnp-3806	3780	6	.	.	PUNCT
fnp-3806	3781	1	https://doi.org/10.1016/j.neuint.2005.07.007	https://doi.org/10.1016/j.neuint.2005.07.007	PROPN
fnp-3806	3781	2	silva	silva	PROPN
fnp-3806	3781	3	pno	pno	PROPN
fnp-3806	3781	4	,	,	PUNCT
fnp-3806	3781	5	gigek	gigek	PROPN
fnp-3806	3781	6	co	co	NOUN
fnp-3806	3781	7	,	,	PUNCT
fnp-3806	3781	8	leal	leal	ADJ
fnp-3806	3781	9	mf	mf	PROPN
fnp-3806	3781	10	,	,	PUNCT
fnp-3806	3781	11	et	et	PROPN
fnp-3806	3781	12	al	al	PROPN
fnp-3806	3781	13	.	.	PROPN
fnp-3806	3781	14	promoter	promoter	PROPN
fnp-3806	3781	15	methylation	methylation	NOUN
fnp-3806	3781	16	analysis	analysis	NOUN
fnp-3806	3781	17	of	of	ADP
fnp-3806	3781	18	sirt3	sirt3	PROPN
fnp-3806	3781	19	,	,	PUNCT
fnp-3806	3781	20	smarca5	smarca5	PROPN
fnp-3806	3781	21	,	,	PUNCT
fnp-3806	3781	22	htert	htert	NOUN
fnp-3806	3781	23	and	and	CCONJ
fnp-3806	3781	24	cdh1	cdh1	NOUN
fnp-3806	3781	25	genes	gene	NOUN
fnp-3806	3781	26	in	in	ADP
fnp-3806	3781	27	aging	aging	NOUN
fnp-3806	3781	28	and	and	CCONJ
fnp-3806	3781	29	alzheimer	alzheimer	PROPN
fnp-3806	3781	30	’s	’s	PART
fnp-3806	3781	31	disease	disease	NOUN
fnp-3806	3781	32	.	.	PUNCT
fnp-3806	3782	1	j	j	PROPN
fnp-3806	3782	2	alzheimers	alzheimers	PROPN
fnp-3806	3782	3	dis	dis	PROPN
fnp-3806	3782	4	2008;13:173	2008;13:173	PROPN
fnp-3806	3782	5	-	-	SYM
fnp-3806	3782	6	176	176	NUM
fnp-3806	3782	7	.	.	PUNCT
fnp-3806	3783	1	https://doi.org/10.3233/jad-2008-13207	https://doi.org/10.3233/jad-2008-13207	PROPN
fnp-3806	3783	2	smith	smith	PROPN
fnp-3806	3783	3	ar	ar	PROPN
fnp-3806	3783	4	,	,	PUNCT
fnp-3806	3783	5	smith	smith	PROPN
fnp-3806	3783	6	rg	rg	PROPN
fnp-3806	3783	7	,	,	PUNCT
fnp-3806	3783	8	condliffe	condliffe	PROPN
fnp-3806	3783	9	d	d	PROPN
fnp-3806	3783	10	,	,	PUNCT
fnp-3806	3783	11	et	et	PROPN
fnp-3806	3783	12	al	al	PROPN
fnp-3806	3783	13	.	.	PROPN
fnp-3806	3783	14	increased	increase	VERB
fnp-3806	3783	15	dna	dna	PROPN
fnp-3806	3783	16	methylation	methylation	NOUN
fnp-3806	3783	17	near	near	ADP
fnp-3806	3783	18	trem2	trem2	NOUN
fnp-3806	3783	19	is	be	AUX
fnp-3806	3783	20	consistently	consistently	ADV
fnp-3806	3783	21	seen	see	VERB
fnp-3806	3783	22	in	in	ADP
fnp-3806	3783	23	the	the	DET
fnp-3806	3783	24	superior	superior	ADJ
fnp-3806	3783	25	temporal	temporal	ADJ
fnp-3806	3783	26	gyrus	gyrus	NOUN
fnp-3806	3783	27	in	in	ADP
fnp-3806	3783	28	alzheimer	alzheimer	PROPN
fnp-3806	3783	29	’s	’s	PART
fnp-3806	3783	30	disease	disease	NOUN
fnp-3806	3783	31	brain	brain	NOUN
fnp-3806	3783	32	.	.	PUNCT
fnp-3806	3784	1	neurobiol	neurobiol	PROPN
fnp-3806	3784	2	aging	age	VERB
fnp-3806	3784	3	2016;47:35	2016;47:35	NUM
fnp-3806	3784	4	-	-	SYM
fnp-3806	3784	5	40	40	NUM
fnp-3806	3784	6	.	.	PUNCT
fnp-3806	3785	1	https://doi.org/10.1016/j.neurobiolaging.2016.07.008	https://doi.org/10.1016/j.neurobiolaging.2016.07.008	PROPN
fnp-3806	3785	2	smith	smith	PROPN
fnp-3806	3785	3	rg	rg	PROPN
fnp-3806	3785	4	,	,	PUNCT
fnp-3806	3785	5	pishva	pishva	NOUN
fnp-3806	3785	6	e	e	NOUN
fnp-3806	3785	7	,	,	PUNCT
fnp-3806	3785	8	shireby	shireby	ADV
fnp-3806	3785	9	g	g	NOUN
fnp-3806	3785	10	,	,	PUNCT
fnp-3806	3785	11	et	et	PROPN
fnp-3806	3785	12	al	al	PROPN
fnp-3806	3785	13	.	.	PUNCT
fnp-3806	3786	1	a	a	DET
fnp-3806	3786	2	meta	meta	ADJ
fnp-3806	3786	3	-	-	PUNCT
fnp-3806	3786	4	analysis	analysis	NOUN
fnp-3806	3786	5	of	of	ADP
fnp-3806	3786	6	epigenome	epigenome	NOUN
fnp-3806	3786	7	-	-	PUNCT
fnp-3806	3786	8	wide	wide	ADJ
fnp-3806	3786	9	association	association	NOUN
fnp-3806	3786	10	studies	study	NOUN
fnp-3806	3786	11	in	in	ADP
fnp-3806	3786	12	alzheimer	alzheimer	PROPN
fnp-3806	3786	13	's	's	PART
fnp-3806	3786	14	disease	disease	NOUN
fnp-3806	3786	15	highlights	highlight	VERB
fnp-3806	3786	16	novel	novel	NOUN
fnp-3806	3786	17	differentially	differentially	ADV
fnp-3806	3786	18	methylated	methylate	VERB
fnp-3806	3786	19	loci	locus	NOUN
fnp-3806	3786	20	across	across	ADP
fnp-3806	3786	21	cortex	cortex	NOUN
fnp-3806	3786	22	.	.	PUNCT
fnp-3806	3787	1	nat	nat	PROPN
fnp-3806	3787	2	commun	commun	PROPN
fnp-3806	3787	3	2021	2021	NUM
fnp-3806	3787	4	;	;	PUNCT
fnp-3806	3787	5	12:3517	12:3517	PROPN
fnp-3806	3787	6	.	.	PROPN
fnp-3806	3787	7	https://doi.org/10.1038/s41467-021-23243-4	https://doi.org/10.1038/s41467-021-23243-4	PROPN
fnp-3806	3787	8	furuya	furuya	PROPN
fnp-3806	3787	9	tk	tk	PROPN
fnp-3806	3787	10	,	,	PUNCT
fnp-3806	3787	11	silva	silva	PROPN
fnp-3806	3787	12	pno	pno	PROPN
fnp-3806	3787	13	,	,	PUNCT
fnp-3806	3787	14	payão	payão	PROPN
fnp-3806	3787	15	slm	slm	PROPN
fnp-3806	3787	16	,	,	PUNCT
fnp-3806	3787	17	et	et	PROPN
fnp-3806	3787	18	al	al	PROPN
fnp-3806	3787	19	.	.	PUNCT
fnp-3806	3787	20	analysis	analysis	NOUN
fnp-3806	3787	21	of	of	ADP
fnp-3806	3787	22	snap25	snap25	NOUN
fnp-3806	3787	23	mrna	mrna	PROPN
fnp-3806	3787	24	expression	expression	NOUN
fnp-3806	3787	25	and	and	CCONJ
fnp-3806	3787	26	promoter	promoter	NOUN
fnp-3806	3787	27	dna	dna	PROPN
fnp-3806	3787	28	methylation	methylation	NOUN
fnp-3806	3787	29	in	in	ADP
fnp-3806	3787	30	brain	brain	NOUN
fnp-3806	3787	31	areas	area	NOUN
fnp-3806	3787	32	of	of	ADP
fnp-3806	3787	33	alzheimer	alzheimer	PROPN
fnp-3806	3787	34	’s	’s	PART
fnp-3806	3787	35	disease	disease	NOUN
fnp-3806	3787	36	patients	patient	NOUN
fnp-3806	3787	37	.	.	PUNCT
fnp-3806	3788	1	neuroscience	neuroscience	NOUN
fnp-3806	3788	2	2012;220:41	2012;220:41	NUM
fnp-3806	3788	3	-	-	SYM
fnp-3806	3788	4	46	46	NUM
fnp-3806	3788	5	.	.	PUNCT
fnp-3806	3789	1	https://doi.org/10.1016/j.neuroscience.2012.06.035	https://doi.org/10.1016/j.neuroscience.2012.06.035	PROPN
fnp-3806	3789	2	furuya	furuya	PROPN
fnp-3806	3789	3	tk	tk	PROPN
fnp-3806	3789	4	,	,	PUNCT
fnp-3806	3789	5	da	da	PROPN
fnp-3806	3789	6	silva	silva	PROPN
fnp-3806	3789	7	pno	pno	PROPN
fnp-3806	3789	8	,	,	PUNCT
fnp-3806	3789	9	payão	payão	PROPN
fnp-3806	3789	10	slm	slm	PROPN
fnp-3806	3789	11	,	,	PUNCT
fnp-3806	3789	12	et	et	PROPN
fnp-3806	3789	13	al	al	PROPN
fnp-3806	3789	14	.	.	PUNCT
fnp-3806	3790	1	sorl1	sorl1	PROPN
fnp-3806	3790	2	and	and	CCONJ
fnp-3806	3790	3	sirt1	sirt1	NOUN
fnp-3806	3790	4	mrna	mrna	NOUN
fnp-3806	3790	5	expression	expression	NOUN
fnp-3806	3790	6	and	and	CCONJ
fnp-3806	3790	7	promoter	promoter	NOUN
fnp-3806	3790	8	methylation	methylation	NOUN
fnp-3806	3790	9	levels	level	NOUN
fnp-3806	3790	10	in	in	ADP
fnp-3806	3790	11	aging	aging	NOUN
fnp-3806	3790	12	and	and	CCONJ
fnp-3806	3790	13	alzheimer	alzheimer	PROPN
fnp-3806	3790	14	’s	’s	PART
fnp-3806	3790	15	disease	disease	NOUN
fnp-3806	3790	16	.	.	PUNCT
fnp-3806	3791	1	neurochem	neurochem	PROPN
fnp-3806	3791	2	int	int	VERB
fnp-3806	3792	1	2012;61:973	2012;61:973	NUM
fnp-3806	3792	2	-	-	SYM
fnp-3806	3792	3	975	975	NUM
fnp-3806	3792	4	.	.	PUNCT
fnp-3806	3793	1	https://doi.org/10.1016/j.neuint.2012.07.014	https://doi.org/10.1016/j.neuint.2012.07.014	PROPN
fnp-3806	3793	2	sanchez	sanchez	PROPN
fnp-3806	3793	3	-	-	PUNCT
fnp-3806	3793	4	mut	mut	PROPN
fnp-3806	3793	5	jv	jv	PROPN
fnp-3806	3793	6	,	,	PUNCT
fnp-3806	3793	7	aso	aso	PROPN
fnp-3806	3793	8	e	e	PROPN
fnp-3806	3793	9	,	,	PUNCT
fnp-3806	3793	10	heyn	heyn	NOUN
fnp-3806	3793	11	h	h	PROPN
fnp-3806	3793	12	,	,	PUNCT
fnp-3806	3793	13	et	et	PROPN
fnp-3806	3793	14	al	al	PROPN
fnp-3806	3793	15	.	.	PROPN
fnp-3806	3793	16	promoter	promoter	NOUN
fnp-3806	3793	17	hypermethylation	hypermethylation	NOUN
fnp-3806	3793	18	of	of	ADP
fnp-3806	3793	19	the	the	DET
fnp-3806	3793	20	phosphatase	phosphatase	NOUN
fnp-3806	3793	21	dusp22	dusp22	NOUN
fnp-3806	3793	22	mediates	mediate	VERB
fnp-3806	3793	23	pka	pka	NOUN
fnp-3806	3793	24	-	-	PUNCT
fnp-3806	3793	25	dependent	dependent	ADJ
fnp-3806	3793	26	tau	tau	PROPN
fnp-3806	3793	27	phosphorylation	phosphorylation	NOUN
fnp-3806	3793	28	and	and	CCONJ
fnp-3806	3793	29	creb	creb	NOUN
fnp-3806	3793	30	activation	activation	NOUN
fnp-3806	3793	31	in	in	ADP
fnp-3806	3793	32	alzheimer	alzheimer	PROPN
fnp-3806	3793	33	's	's	PART
fnp-3806	3793	34	disease	disease	NOUN
fnp-3806	3793	35	.	.	PUNCT
fnp-3806	3794	1	hippocampus	hippocampus	VERB
fnp-3806	3794	2	2014;24:363	2014;24:363	NOUN
fnp-3806	3794	3	-	-	PUNCT
fnp-3806	3794	4	368	368	NUM
fnp-3806	3794	5	.	.	PUNCT
fnp-3806	3795	1	https://doi.org/10.1002/hipo.22245	https://doi.org/10.1002/hipo.22245	PROPN
fnp-3806	3795	2	de	de	PROPN
fnp-3806	3795	3	jager	jager	PROPN
fnp-3806	3795	4	pl	pl	PROPN
fnp-3806	3795	5	,	,	PUNCT
fnp-3806	3795	6	srivastava	srivastava	PROPN
fnp-3806	3795	7	g	g	PROPN
fnp-3806	3795	8	,	,	PUNCT
fnp-3806	3795	9	burgess	burgess	PROPN
fnp-3806	3795	10	j	j	PROPN
fnp-3806	3795	11	,	,	PUNCT
fnp-3806	3795	12	et	et	PROPN
fnp-3806	3795	13	al	al	PROPN
fnp-3806	3795	14	.	.	PROPN
fnp-3806	3795	15	alzheimer	alzheimer	PROPN
fnp-3806	3795	16	’s	’s	PART
fnp-3806	3795	17	disease	disease	NOUN
fnp-3806	3795	18	:	:	PUNCT
fnp-3806	3795	19	early	early	ADJ
fnp-3806	3795	20	alterations	alteration	NOUN
fnp-3806	3795	21	in	in	ADP
fnp-3806	3795	22	brain	brain	NOUN
fnp-3806	3795	23	dna	dna	PROPN
fnp-3806	3795	24	methylation	methylation	NOUN
fnp-3806	3795	25	at	at	ADP
fnp-3806	3795	26	ank1	ank1	PROPN
fnp-3806	3795	27	,	,	PUNCT
fnp-3806	3795	28	bin1	bin1	PROPN
fnp-3806	3795	29	,	,	PUNCT
fnp-3806	3795	30	rhbdf2	rhbdf2	NOUN
fnp-3806	3795	31	and	and	CCONJ
fnp-3806	3795	32	other	other	ADJ
fnp-3806	3795	33	loci	locus	NOUN
fnp-3806	3795	34	.	.	PUNCT
fnp-3806	3796	1	nat	nat	PROPN
fnp-3806	3796	2	neurosci	neurosci	PROPN
fnp-3806	3796	3	2014	2014	NUM
fnp-3806	3796	4	;	;	PUNCT
fnp-3806	3796	5	17:1156	17:1156	NUM
fnp-3806	3796	6	-	-	SYM
fnp-3806	3796	7	1163	1163	NUM
fnp-3806	3796	8	.	.	PUNCT
fnp-3806	3797	1	https://doi.org/10.1038/nn.3786	https://doi.org/10.1038/nn.3786	X
fnp-3806	3797	2	lunnon	lunnon	PROPN
fnp-3806	3798	1	k	k	PROPN
fnp-3806	3798	2	,	,	PUNCT
fnp-3806	3798	3	smith	smith	PROPN
fnp-3806	3798	4	r	r	PROPN
fnp-3806	3798	5	,	,	PUNCT
fnp-3806	3798	6	hannon	hannon	PROPN
fnp-3806	3798	7	e	e	PROPN
fnp-3806	3798	8	,	,	PUNCT
fnp-3806	3798	9	et	et	PROPN
fnp-3806	3798	10	al	al	PROPN
fnp-3806	3798	11	.	.	PUNCT
fnp-3806	3799	1	methylomic	methylomic	ADJ
fnp-3806	3799	2	profiling	profiling	NOUN
fnp-3806	3799	3	implicates	implicate	VERB
fnp-3806	3799	4	cortical	cortical	ADJ
fnp-3806	3799	5	deregulation	deregulation	NOUN
fnp-3806	3799	6	of	of	ADP
fnp-3806	3799	7	ank1	ank1	PROPN
fnp-3806	3799	8	in	in	ADP
fnp-3806	3799	9	alzheimer	alzheimer	PROPN
fnp-3806	3799	10	’s	’s	PART
fnp-3806	3799	11	disease	disease	NOUN
fnp-3806	3799	12	.	.	PUNCT
fnp-3806	3800	1	nat	nat	PROPN
fnp-3806	3800	2	neurosci	neurosci	PROPN
fnp-3806	3800	3	2014;17:1164–1170	2014;17:1164–1170	PROPN
fnp-3806	3800	4	.	.	PUNCT
fnp-3806	3801	1	https://doi.org/10.1038/nn.3782	https://doi.org/10.1038/nn.3782	PROPN
fnp-3806	3801	2	shinagawa	shinagawa	PROPN
fnp-3806	3801	3	s	s	PROPN
fnp-3806	3801	4	,	,	PUNCT
fnp-3806	3801	5	kobayashi	kobayashi	PROPN
fnp-3806	3801	6	n	n	CCONJ
fnp-3806	3801	7	,	,	PUNCT
fnp-3806	3801	8	nagata	nagata	PROPN
fnp-3806	3801	9	t	t	PROPN
fnp-3806	3801	10	,	,	PUNCT
fnp-3806	3801	11	et	et	PROPN
fnp-3806	3801	12	al	al	PROPN
fnp-3806	3801	13	.	.	PROPN
fnp-3806	3802	1	dna	dna	PROPN
fnp-3806	3802	2	methylation	methylation	NOUN
fnp-3806	3802	3	in	in	ADP
fnp-3806	3802	4	the	the	DET
fnp-3806	3802	5	ncaph2	ncaph2	PROPN
fnp-3806	3802	6	/	/	SYM
fnp-3806	3802	7	lmf2	lmf2	NOUN
fnp-3806	3802	8	promoter	promoter	NOUN
fnp-3806	3802	9	region	region	NOUN
fnp-3806	3802	10	is	be	AUX
fnp-3806	3802	11	associated	associate	VERB
fnp-3806	3802	12	with	with	ADP
fnp-3806	3802	13	hippocampal	hippocampal	ADJ
fnp-3806	3802	14	atrophy	atrophy	NOUN
fnp-3806	3802	15	in	in	ADP
fnp-3806	3802	16	alzheimer	alzheimer	PROPN
fnp-3806	3802	17	’s	’s	PART
fnp-3806	3802	18	disease	disease	NOUN
fnp-3806	3802	19	and	and	CCONJ
fnp-3806	3802	20	amnesic	amnesic	ADJ
fnp-3806	3802	21	mild	mild	ADJ
fnp-3806	3802	22	cognitive	cognitive	ADJ
fnp-3806	3802	23	impairment	impairment	NOUN
fnp-3806	3802	24	patients	patient	NOUN
fnp-3806	3802	25	.	.	PUNCT
fnp-3806	3803	1	neurosci	neurosci	PROPN
fnp-3806	3803	2	lett	lett	PROPN
fnp-3806	3803	3	2016;629:33–37	2016;629:33–37	PROPN
fnp-3806	3803	4	.	.	PUNCT
fnp-3806	3804	1	https://doi.org/10.1016/j.neulet.2016.06.055	https://doi.org/10.1016/j.neulet.2016.06.055	PROPN
fnp-3806	3804	2	buira	buira	PROPN
fnp-3806	3804	3	sp	sp	PROPN
fnp-3806	3804	4	,	,	PUNCT
fnp-3806	3804	5	albasanz	albasanz	PROPN
fnp-3806	3804	6	jl	jl	NOUN
fnp-3806	3804	7	,	,	PUNCT
fnp-3806	3804	8	dentesano	dentesano	VERB
fnp-3806	3804	9	g	g	NOUN
fnp-3806	3804	10	,	,	PUNCT
fnp-3806	3804	11	et	et	PROPN
fnp-3806	3804	12	al	al	PROPN
fnp-3806	3804	13	.	.	PROPN
fnp-3806	3805	1	dna	dna	PROPN
fnp-3806	3805	2	methylation	methylation	NOUN
fnp-3806	3805	3	regulates	regulate	VERB
fnp-3806	3805	4	adenosine	adenosine	NOUN
fnp-3806	3805	5	a(2a	a(2a	NOUN
fnp-3806	3805	6	)	)	PUNCT
fnp-3806	3805	7	receptor	receptor	NOUN
fnp-3806	3805	8	cell	cell	NOUN
fnp-3806	3805	9	surface	surface	NOUN
fnp-3806	3805	10	expression	expression	NOUN
fnp-3806	3805	11	levels	level	NOUN
fnp-3806	3805	12	.	.	PUNCT
fnp-3806	3806	1	j	j	PROPN
fnp-3806	3806	2	neurochem	neurochem	PROPN
fnp-3806	3806	3	2010;112:1273	2010;112:1273	NUM
fnp-3806	3806	4	-	-	SYM
fnp-3806	3806	5	1285	1285	NUM
fnp-3806	3806	6	.	.	PUNCT
fnp-3806	3807	1	https://doi.org/10.1111/j.1471-4159.2009.06538.x	https://doi.org/10.1111/j.1471-4159.2009.06538.x	PROPN
fnp-3806	3807	2	buira	buira	PROPN
fnp-3806	3807	3	sp	sp	PROPN
fnp-3806	3807	4	,	,	PUNCT
fnp-3806	3807	5	dentesano	dentesano	VERB
fnp-3806	3807	6	g	g	NOUN
fnp-3806	3807	7	,	,	PUNCT
fnp-3806	3807	8	albasanz	albasanz	PROPN
fnp-3806	3807	9	jl	jl	PROPN
fnp-3806	3807	10	,	,	PUNCT
fnp-3806	3807	11	et	et	PROPN
fnp-3806	3807	12	al	al	PROPN
fnp-3806	3807	13	.	.	PROPN
fnp-3806	3807	14	dna	dna	PROPN
fnp-3806	3807	15	methylation	methylation	NOUN
fnp-3806	3807	16	and	and	CCONJ
fnp-3806	3807	17	yin	yin	PROPN
fnp-3806	3807	18	yang-1	yang-1	PRON
fnp-3806	3807	19	repress	repress	VERB
fnp-3806	3807	20	adenosine	adenosine	NOUN
fnp-3806	3807	21	a2a	a2a	PROPN
fnp-3806	3807	22	receptor	receptor	NOUN
fnp-3806	3807	23	levels	level	NOUN
fnp-3806	3807	24	in	in	ADP
fnp-3806	3807	25	human	human	ADJ
fnp-3806	3807	26	brain	brain	NOUN
fnp-3806	3807	27	.	.	PUNCT
fnp-3806	3808	1	j	j	PROPN
fnp-3806	3808	2	neurochem	neurochem	PROPN
fnp-3806	3808	3	2010;115:283	2010;115:283	NUM
fnp-3806	3808	4	-	-	SYM
fnp-3806	3808	5	295	295	NUM
fnp-3806	3808	6	.	.	PUNCT
fnp-3806	3809	1	https://doi.org/10.1111/j.1471-4159.2010.06928.x	https://doi.org/10.1111/j.1471-4159.2010.06928.x	ADJ
fnp-3806	3809	2	villar	villar	PROPN
fnp-3806	3809	3	-	-	PUNCT
fnp-3806	3809	4	menéndez	menéndez	PROPN
fnp-3806	3809	5	i	i	PROPN
fnp-3806	3809	6	,	,	PUNCT
fnp-3806	3809	7	nuñez	nuñez	PROPN
fnp-3806	3809	8	f	f	PROPN
fnp-3806	3809	9	,	,	PUNCT
fnp-3806	3809	10	díaz	díaz	NOUN
fnp-3806	3809	11	-	-	PUNCT
fnp-3806	3809	12	sánchez	sánchez	NOUN
fnp-3806	3809	13	s	s	PROPN
fnp-3806	3809	14	,	,	PUNCT
fnp-3806	3809	15	et	et	PROPN
fnp-3806	3809	16	al	al	PROPN
fnp-3806	3809	17	.	.	PUNCT
fnp-3806	3810	1	striatal	striatal	ADJ
fnp-3806	3810	2	adenosine	adenosine	NOUN
fnp-3806	3810	3	a2a	a2a	PROPN
fnp-3806	3810	4	receptor	receptor	NOUN
fnp-3806	3810	5	expression	expression	NOUN
fnp-3806	3810	6	is	be	AUX
fnp-3806	3810	7	controlled	control	VERB
fnp-3806	3810	8	by	by	ADP
fnp-3806	3810	9	s	s	NOUN
fnp-3806	3810	10	-	-	PUNCT
fnp-3806	3810	11	adenosyl	adenosyl	ADJ
fnp-3806	3810	12	-	-	PUNCT
fnp-3806	3810	13	l	l	NOUN
fnp-3806	3810	14	-	-	PUNCT
fnp-3806	3810	15	methionine	methionine	NOUN
fnp-3806	3810	16	-	-	PUNCT
fnp-3806	3810	17	mediated	mediate	VERB
fnp-3806	3810	18	methylation	methylation	NOUN
fnp-3806	3810	19	.	.	PUNCT
fnp-3806	3811	1	purinergic	purinergic	NOUN
fnp-3806	3811	2	signal	signal	NOUN
fnp-3806	3811	3	2014;10:523	2014;10:523	PROPN
fnp-3806	3811	4	-	-	SYM
fnp-3806	3811	5	528	528	NUM
fnp-3806	3811	6	.	.	PUNCT
fnp-3806	3812	1	https://doi.org/10.1007/s11302-014-9417-4	https://doi.org/10.1007/s11302-014-9417-4	VERB
fnp-3806	3812	2	piaceri	piaceri	PROPN
fnp-3806	3812	3	i	i	PRON
fnp-3806	3812	4	,	,	PUNCT
fnp-3806	3812	5	raspanti	raspanti	PROPN
fnp-3806	3812	6	b	b	PROPN
fnp-3806	3812	7	,	,	PUNCT
fnp-3806	3812	8	tedde	tedde	VERB
fnp-3806	3812	9	a	a	PRON
fnp-3806	3812	10	,	,	PUNCT
fnp-3806	3812	11	et	et	PROPN
fnp-3806	3812	12	al	al	PROPN
fnp-3806	3812	13	.	.	PUNCT
fnp-3806	3813	1	epigenetic	epigenetic	ADJ
fnp-3806	3813	2	modifications	modification	NOUN
fnp-3806	3813	3	in	in	ADP
fnp-3806	3813	4	alzheimer	alzheimer	PROPN
fnp-3806	3813	5	’s	’s	PART
fnp-3806	3813	6	disease	disease	NOUN
fnp-3806	3813	7	:	:	PUNCT
fnp-3806	3813	8	cause	cause	VERB
fnp-3806	3813	9	or	or	CCONJ
fnp-3806	3813	10	effect	effect	VERB
fnp-3806	3813	11	?	?	PUNCT
fnp-3806	3814	1	j	j	PROPN
fnp-3806	3814	2	alzheimers	alzheimers	PROPN
fnp-3806	3814	3	dis	dis	PROPN
fnp-3806	3814	4	2015;43:1169	2015;43:1169	NUM
fnp-3806	3814	5	-	-	SYM
fnp-3806	3814	6	1173	1173	NUM
fnp-3806	3814	7	.	.	PUNCT
fnp-3806	3815	1	https://doi.org/10.3233/jad-141452	https://doi.org/10.3233/jad-141452	NOUN
fnp-3806	3815	2	blanch	blanch	PROPN
fnp-3806	3815	3	m	m	PROPN
fnp-3806	3815	4	,	,	PUNCT
fnp-3806	3815	5	mosquera	mosquera	ADJ
fnp-3806	3815	6	jl	jl	NOUN
fnp-3806	3815	7	,	,	PUNCT
fnp-3806	3815	8	ansoleaga	ansoleaga	NOUN
fnp-3806	3815	9	b	b	PROPN
fnp-3806	3815	10	,	,	PUNCT
fnp-3806	3815	11	et	et	PROPN
fnp-3806	3815	12	al	al	PROPN
fnp-3806	3815	13	.	.	PROPN
fnp-3806	3815	14	altered	alter	VERB
fnp-3806	3815	15	mitochondrial	mitochondrial	ADJ
fnp-3806	3815	16	dna	dna	PROPN
fnp-3806	3815	17	methylation	methylation	NOUN
fnp-3806	3815	18	pattern	pattern	NOUN
fnp-3806	3815	19	in	in	ADP
fnp-3806	3815	20	alzheimer	alzheimer	PROPN
fnp-3806	3815	21	disease	disease	NOUN
fnp-3806	3815	22	-	-	PUNCT
fnp-3806	3815	23	related	relate	VERB
fnp-3806	3815	24	pathology	pathology	NOUN
fnp-3806	3815	25	and	and	CCONJ
fnp-3806	3815	26	in	in	ADP
fnp-3806	3815	27	parkinson	parkinson	NOUN
fnp-3806	3815	28	disease	disease	NOUN
fnp-3806	3815	29	.	.	PUNCT
fnp-3806	3816	1	am	be	AUX
fnp-3806	3816	2	j	j	PROPN
fnp-3806	3816	3	pathol	pathol	NOUN
fnp-3806	3816	4	2016;186:385	2016;186:385	PROPN
fnp-3806	3816	5	-	-	SYM
fnp-3806	3816	6	397	397	NUM
fnp-3806	3816	7	.	.	PUNCT
fnp-3806	3817	1	https://doi.org/10.1016/j.ajpath.2015.10.004	https://doi.org/10.1016/j.ajpath.2015.10.004	VERB
fnp-3806	3817	2	eddy	eddy	PROPN
fnp-3806	3817	3	sr	sr	PROPN
fnp-3806	3817	4	.	.	PUNCT
fnp-3806	3818	1	non	non	ADJ
fnp-3806	3818	2	-	-	ADJ
fnp-3806	3818	3	coding	code	VERB
fnp-3806	3818	4	rna	rna	NOUN
fnp-3806	3818	5	genes	gene	NOUN
fnp-3806	3818	6	and	and	CCONJ
fnp-3806	3818	7	the	the	DET
fnp-3806	3818	8	modern	modern	ADJ
fnp-3806	3818	9	rna	rna	NOUN
fnp-3806	3818	10	world	world	NOUN
fnp-3806	3818	11	.	.	PUNCT
fnp-3806	3819	1	nat	nat	PROPN
fnp-3806	3819	2	rev	rev	PROPN
fnp-3806	3819	3	genet	genet	PROPN
fnp-3806	3819	4	2001;2:919	2001;2:919	PROPN
fnp-3806	3819	5	-	-	PUNCT
fnp-3806	3819	6	929	929	NUM
fnp-3806	3819	7	.	.	PUNCT
fnp-3806	3820	1	https://doi.org/10.1038/35103511	https://doi.org/10.1038/35103511	NOUN
fnp-3806	3821	1	he	he	PRON
fnp-3806	3821	2	l	l	NOUN
fnp-3806	3821	3	,	,	PUNCT
fnp-3806	3821	4	hannon	hannon	PROPN
fnp-3806	3821	5	gj	gj	PROPN
fnp-3806	3821	6	.	.	PUNCT
fnp-3806	3821	7	micrornas	microrna	NOUN
fnp-3806	3821	8	:	:	PUNCT
fnp-3806	3821	9	small	small	ADJ
fnp-3806	3821	10	rnas	rna	NOUN
fnp-3806	3821	11	with	with	ADP
fnp-3806	3821	12	a	a	DET
fnp-3806	3821	13	big	big	ADJ
fnp-3806	3821	14	role	role	NOUN
fnp-3806	3821	15	in	in	ADP
fnp-3806	3821	16	gene	gene	NOUN
fnp-3806	3821	17	regulation	regulation	NOUN
fnp-3806	3821	18	.	.	PUNCT
fnp-3806	3822	1	nat	nat	PROPN
fnp-3806	3822	2	rev	rev	VERB
fnp-3806	3822	3	genet	genet	PROPN
fnp-3806	3822	4	2004;5:522	2004;5:522	PROPN
fnp-3806	3822	5	-	-	SYM
fnp-3806	3822	6	531	531	NUM
fnp-3806	3822	7	.	.	PUNCT
fnp-3806	3823	1	https://doi.org/10.1038/nrg1379	https://doi.org/10.1038/nrg1379	PROPN
fnp-3806	3823	2	bartel	bartel	PROPN
fnp-3806	3823	3	dp	dp	PROPN
fnp-3806	3823	4	.	.	PUNCT
fnp-3806	3823	5	micrornas	microrna	NOUN
fnp-3806	3823	6	:	:	PUNCT
fnp-3806	3823	7	target	target	NOUN
fnp-3806	3823	8	recognition	recognition	NOUN
fnp-3806	3823	9	and	and	CCONJ
fnp-3806	3823	10	regulatory	regulatory	ADJ
fnp-3806	3823	11	functions	function	NOUN
fnp-3806	3823	12	.	.	PUNCT
fnp-3806	3824	1	cell	cell	NOUN
fnp-3806	3824	2	2009;136	2009;136	NUM
fnp-3806	3824	3	:	:	PUNCT
fnp-3806	3824	4	215	215	NUM
fnp-3806	3824	5	-	-	SYM
fnp-3806	3824	6	233	233	NUM
fnp-3806	3824	7	.	.	PUNCT
fnp-3806	3825	1	https://doi.org/10.1016/j.cell.2009.01.002	https://doi.org/10.1016/j.cell.2009.01.002	NUM
fnp-3806	3825	2	kim	kim	PROPN
fnp-3806	3825	3	vn	vn	PROPN
fnp-3806	3825	4	,	,	PUNCT
fnp-3806	3825	5	han	han	PROPN
fnp-3806	3825	6	j	j	PROPN
fnp-3806	3825	7	,	,	PUNCT
fnp-3806	3825	8	siomi	siomi	PROPN
fnp-3806	3825	9	mc	mc	PROPN
fnp-3806	3825	10	.	.	PROPN
fnp-3806	3825	11	biogenesis	biogenesis	NOUN
fnp-3806	3825	12	of	of	ADP
fnp-3806	3825	13	small	small	ADJ
fnp-3806	3825	14	rnas	rna	NOUN
fnp-3806	3825	15	in	in	ADP
fnp-3806	3825	16	animals	animal	NOUN
fnp-3806	3825	17	.	.	PUNCT
fnp-3806	3826	1	nat	nat	PROPN
fnp-3806	3826	2	rev	rev	VERB
fnp-3806	3826	3	mol	mol	ADP
fnp-3806	3826	4	biol	biol	PROPN
fnp-3806	3826	5	2009;10:126	2009;10:126	NOUN
fnp-3806	3826	6	-	-	SYM
fnp-3806	3826	7	139	139	NUM
fnp-3806	3826	8	.	.	PUNCT
fnp-3806	3827	1	https://doi.org/10.1038/nrm2632	https://doi.org/10.1038/nrm2632	PROPN
fnp-3806	3827	2	wahid	wahid	PROPN
fnp-3806	3827	3	f	f	PROPN
fnp-3806	3827	4	,	,	PUNCT
fnp-3806	3827	5	shezhad	shezhad	VERB
fnp-3806	3827	6	a	a	PRON
fnp-3806	3827	7	,	,	PUNCT
fnp-3806	3827	8	khan	khan	PROPN
fnp-3806	3827	9	t	t	PROPN
fnp-3806	3827	10	,	,	PUNCT
fnp-3806	3827	11	et	et	PROPN
fnp-3806	3827	12	al	al	PROPN
fnp-3806	3827	13	.	.	PROPN
fnp-3806	3827	14	micrornas	microrna	NOUN
fnp-3806	3827	15	:	:	PUNCT
fnp-3806	3827	16	synthesis	synthesis	NOUN
fnp-3806	3827	17	,	,	PUNCT
fnp-3806	3827	18	mechanism	mechanism	NOUN
fnp-3806	3827	19	,	,	PUNCT
fnp-3806	3827	20	function	function	NOUN
fnp-3806	3827	21	,	,	PUNCT
fnp-3806	3827	22	and	and	CCONJ
fnp-3806	3827	23	recent	recent	ADJ
fnp-3806	3827	24	clinical	clinical	ADJ
fnp-3806	3827	25	trials	trial	NOUN
fnp-3806	3827	26	.	.	PUNCT
fnp-3806	3828	1	bioch	bioch	PROPN
fnp-3806	3828	2	biophys	biophys	PROPN
fnp-3806	3828	3	acta	acta	PROPN
fnp-3806	3828	4	mol	mol	ADP
fnp-3806	3828	5	cell	cell	NOUN
fnp-3806	3828	6	res	re	NOUN
fnp-3806	3828	7	2010;1803:1231	2010;1803:1231	NOUN
fnp-3806	3828	8	-	-	PUNCT
fnp-3806	3828	9	1243	1243	NUM
fnp-3806	3828	10	.	.	PUNCT
fnp-3806	3829	1	https://doi.org/10.1016/j.bbamcr.2010.06.013	https://doi.org/10.1016/j.bbamcr.2010.06.013	PROPN
fnp-3806	3829	2	lewis	lewis	PROPN
fnp-3806	3829	3	bp	bp	PROPN
fnp-3806	3829	4	,	,	PUNCT
fnp-3806	3829	5	burge	burge	PROPN
fnp-3806	3829	6	cb	cb	PROPN
fnp-3806	3829	7	,	,	PUNCT
fnp-3806	3829	8	bartel	bartel	PROPN
fnp-3806	3829	9	dp	dp	PROPN
fnp-3806	3829	10	.	.	PROPN
fnp-3806	3829	11	conserved	conserve	VERB
fnp-3806	3829	12	seed	seed	NOUN
fnp-3806	3829	13	pairing	pairing	NOUN
fnp-3806	3829	14	,	,	PUNCT
fnp-3806	3829	15	often	often	ADV
fnp-3806	3829	16	flanked	flank	VERB
fnp-3806	3829	17	by	by	ADP
fnp-3806	3829	18	adenosines	adenosine	NOUN
fnp-3806	3829	19	,	,	PUNCT
fnp-3806	3829	20	indicates	indicate	VERB
fnp-3806	3829	21	that	that	SCONJ
fnp-3806	3829	22	thousands	thousand	NOUN
fnp-3806	3829	23	of	of	ADP
fnp-3806	3829	24	human	human	ADJ
fnp-3806	3829	25	genes	gene	NOUN
fnp-3806	3829	26	are	be	AUX
fnp-3806	3829	27	microrna	microrna	PROPN
fnp-3806	3829	28	targets	target	NOUN
fnp-3806	3829	29	.	.	PUNCT
fnp-3806	3830	1	cell	cell	NOUN
fnp-3806	3830	2	2005;120:15	2005;120:15	NUM
fnp-3806	3830	3	-	-	SYM
fnp-3806	3830	4	20	20	NUM
fnp-3806	3830	5	.	.	PUNCT
fnp-3806	3831	1	https://doi.org/10.1016/j.cell.2004.12.035	https://doi.org/10.1016/j.cell.2004.12.035	PROPN
fnp-3806	3831	2	lewis	lewis	PROPN
fnp-3806	3831	3	bp	bp	PROPN
fnp-3806	3831	4	,	,	PUNCT
fnp-3806	3831	5	shih	shih	PROPN
fnp-3806	3831	6	ih	ih	PROPN
fnp-3806	3831	7	,	,	PUNCT
fnp-3806	3831	8	jones	jones	PROPN
fnp-3806	3831	9	-	-	PUNCT
fnp-3806	3831	10	rhoades	rhoade	NOUN
fnp-3806	3831	11	mw	mw	PROPN
fnp-3806	3831	12	,	,	PUNCT
fnp-3806	3831	13	et	et	PROPN
fnp-3806	3831	14	al	al	PROPN
fnp-3806	3831	15	.	.	PROPN
fnp-3806	3831	16	prediction	prediction	NOUN
fnp-3806	3831	17	of	of	ADP
fnp-3806	3831	18	mammalian	mammalian	PROPN
fnp-3806	3831	19	microrna	microrna	PROPN
fnp-3806	3831	20	targets	target	NOUN
fnp-3806	3831	21	.	.	PUNCT
fnp-3806	3832	1	cell	cell	NOUN
fnp-3806	3832	2	2003;115	2003;115	NUM
fnp-3806	3832	3	:	:	PUNCT
fnp-3806	3832	4	787	787	NUM
fnp-3806	3832	5	-	-	SYM
fnp-3806	3832	6	798	798	NUM
fnp-3806	3832	7	.	.	PUNCT
fnp-3806	3833	1	https://doi.org/10.1016/s0092-8674(03)01018-3	https://doi.org/10.1016/s0092-8674(03)01018-3	PROPN
fnp-3806	3833	2	boudreau	boudreau	PROPN
fnp-3806	3833	3	rl	rl	PROPN
fnp-3806	3833	4	,	,	PUNCT
fnp-3806	3833	5	jiang	jiang	PROPN
fnp-3806	3833	6	p	p	PROPN
fnp-3806	3833	7	,	,	PUNCT
fnp-3806	3833	8	gilmore	gilmore	PROPN
fnp-3806	3833	9	bl	bl	PROPN
fnp-3806	3833	10	,	,	PUNCT
fnp-3806	3833	11	et	et	PROPN
fnp-3806	3833	12	al	al	PROPN
fnp-3806	3833	13	.	.	PUNCT
fnp-3806	3834	1	transcriptome	transcriptome	NOUN
fnp-3806	3834	2	-	-	PUNCT
fnp-3806	3834	3	wide	wide	ADJ
fnp-3806	3834	4	discovery	discovery	NOUN
fnp-3806	3834	5	of	of	ADP
fnp-3806	3834	6	microrna	microrna	PROPN
fnp-3806	3834	7	binding	bind	VERB
fnp-3806	3834	8	sites	site	NOUN
fnp-3806	3834	9	in	in	ADP
fnp-3806	3834	10	human	human	ADJ
fnp-3806	3834	11	brain	brain	NOUN
fnp-3806	3834	12	.	.	PUNCT
fnp-3806	3835	1	neuron	neuron	PROPN
fnp-3806	3835	2	2014;81	2014;81	NUM
fnp-3806	3835	3	:	:	PUNCT
fnp-3806	3835	4	294	294	NUM
fnp-3806	3835	5	-	-	SYM
fnp-3806	3835	6	305	305	NUM
fnp-3806	3835	7	.	.	PUNCT
fnp-3806	3836	1	https://doi.org/10.1016/j.neuron.2013.10.062	https://doi.org/10.1016/j.neuron.2013.10.062	NUM
fnp-3806	3836	2	tan	tan	PROPN
fnp-3806	3836	3	l	l	NOUN
fnp-3806	3836	4	,	,	PUNCT
fnp-3806	3836	5	yu	yu	PROPN
fnp-3806	3836	6	jt	jt	PROPN
fnp-3806	3836	7	,	,	PUNCT
fnp-3806	3836	8	hu	hu	PROPN
fnp-3806	3836	9	n	n	CCONJ
fnp-3806	3836	10	,	,	PUNCT
fnp-3806	3836	11	et	et	PROPN
fnp-3806	3836	12	al	al	PROPN
fnp-3806	3836	13	.	.	PUNCT
fnp-3806	3837	1	non	non	ADJ
fnp-3806	3837	2	-	-	ADJ
fnp-3806	3837	3	coding	coding	ADJ
fnp-3806	3837	4	rnas	rna	NOUN
fnp-3806	3837	5	in	in	ADP
fnp-3806	3837	6	alzheimer	alzheimer	PROPN
fnp-3806	3837	7	’s	’s	PART
fnp-3806	3837	8	disease	disease	NOUN
fnp-3806	3837	9	.	.	PUNCT
fnp-3806	3838	1	mol	mol	ADP
fnp-3806	3838	2	neurobiol	neurobiol	NOUN
fnp-3806	3838	3	2013;47:382	2013;47:382	NOUN
fnp-3806	3838	4	-	-	SYM
fnp-3806	3838	5	393	393	NUM
fnp-3806	3838	6	.	.	PUNCT
fnp-3806	3839	1	https://doi.org/10.1007/s12035-012-8359-5	https://doi.org/10.1007/s12035-012-8359-5	PROPN
fnp-3806	3839	2	dehgani	dehgani	PROPN
fnp-3806	3839	3	r	r	PROPN
fnp-3806	3839	4	,	,	PUNCT
fnp-3806	3839	5	rahmani	rahmani	X
fnp-3806	3839	6	f	f	X
fnp-3806	3839	7	,	,	PUNCT
fnp-3806	3839	8	rezaei	rezaei	PROPN
fnp-3806	3839	9	n.	n.	PROPN
fnp-3806	3839	10	microrna	microrna	PROPN
fnp-3806	3839	11	in	in	ADP
fnp-3806	3839	12	alzheimer	alzheimer	PROPN
fnp-3806	3839	13	’s	’s	PART
fnp-3806	3839	14	disease	disease	NOUN
fnp-3806	3839	15	revisited	revisit	VERB
fnp-3806	3839	16	:	:	PUNCT
fnp-3806	3839	17	implications	implication	NOUN
fnp-3806	3839	18	for	for	ADP
fnp-3806	3839	19	major	major	ADJ
fnp-3806	3839	20	neuropathological	neuropathological	ADJ
fnp-3806	3839	21	mechanisms	mechanism	NOUN
fnp-3806	3839	22	.	.	PUNCT
fnp-3806	3840	1	rev	rev	PROPN
fnp-3806	3840	2	neurosci	neurosci	PROPN
fnp-3806	3840	3	2018;29:161	2018;29:161	NOUN
fnp-3806	3840	4	-	-	SYM
fnp-3806	3840	5	182	182	NUM
fnp-3806	3840	6	.	.	PUNCT
fnp-3806	3841	1	https://doi.org/10.1515/revneuro-2017-0042	https://doi.org/10.1515/revneuro-2017-0042	PROPN
fnp-3806	3841	2	wang	wang	PROPN
fnp-3806	3841	3	m	m	PROPN
fnp-3806	3841	4	,	,	PUNCT
fnp-3806	3841	5	qin	qin	PROPN
fnp-3806	3841	6	l	l	PROPN
fnp-3806	3841	7	,	,	PUNCT
fnp-3806	3841	8	tang	tang	PROPN
fnp-3806	3841	9	b.	b.	PROPN
fnp-3806	3841	10	micrornas	micrornas	PROPN
fnp-3806	3841	11	in	in	ADP
fnp-3806	3841	12	alzheimer	alzheimer	PROPN
fnp-3806	3841	13	’s	’s	PART
fnp-3806	3841	14	disease	disease	NOUN
fnp-3806	3841	15	.	.	PUNCT
fnp-3806	3842	1	front	front	ADJ
fnp-3806	3842	2	genet	genet	PROPN
fnp-3806	3842	3	2019;10	2019;10	PROPN
fnp-3806	3842	4	:	:	PUNCT
fnp-3806	3842	5	153	153	NUM
fnp-3806	3842	6	.	.	PUNCT
fnp-3806	3843	1	https://doi.org/10.3389/fgene.2019.00153	https://doi.org/10.3389/fgene.2019.00153	PROPN
fnp-3806	3843	2	lee	lee	PROPN
fnp-3806	3843	3	st	st	PROPN
fnp-3806	3843	4	,	,	PUNCT
fnp-3806	3843	5	chu	chu	PROPN
fnp-3806	3843	6	k	k	PROPN
fnp-3806	3843	7	,	,	PUNCT
fnp-3806	3843	8	jung	jung	PROPN
fnp-3806	3843	9	kh	kh	PROPN
fnp-3806	3843	10	,	,	PUNCT
fnp-3806	3843	11	et	et	PROPN
fnp-3806	3843	12	al	al	PROPN
fnp-3806	3843	13	.	.	PROPN
fnp-3806	3843	14	mir-206	mir-206	PROPN
fnp-3806	3843	15	regulates	regulate	VERB
fnp-3806	3843	16	brain	brain	NOUN
fnp-3806	3843	17	-	-	PUNCT
fnp-3806	3843	18	derived	derive	VERB
fnp-3806	3843	19	neurotrophic	neurotrophic	ADJ
fnp-3806	3843	20	factor	factor	NOUN
fnp-3806	3843	21	in	in	ADP
fnp-3806	3843	22	alzheimer	alzheimer	PROPN
fnp-3806	3843	23	disease	disease	PROPN
fnp-3806	3843	24	model	model	NOUN
fnp-3806	3843	25	.	.	PUNCT
fnp-3806	3844	1	ann	ann	PROPN
fnp-3806	3844	2	neurol	neurol	PROPN
fnp-3806	3844	3	2012;72:269	2012;72:269	PROPN
fnp-3806	3844	4	-	-	NUM
fnp-3806	3844	5	277	277	NUM
fnp-3806	3844	6	.	.	PUNCT
fnp-3806	3845	1	https://doi.org/10.1002/ana.23588	https://doi.org/10.1002/ana.23588	PROPN
fnp-3806	3845	2	hébert	hébert	PROPN
fnp-3806	3845	3	ss	ss	PROPN
fnp-3806	3845	4	,	,	PUNCT
fnp-3806	3845	5	horre	horre	PROPN
fnp-3806	3845	6	k	k	PROPN
fnp-3806	3845	7	,	,	PUNCT
fnp-3806	3845	8	nicolai	nicolai	PROPN
fnp-3806	3845	9	l	l	PROPN
fnp-3806	3845	10	,	,	PUNCT
fnp-3806	3846	1	et	et	PROPN
fnp-3806	3846	2	al	al	PROPN
fnp-3806	3846	3	.	.	PUNCT
fnp-3806	3846	4	microrna	microrna	PROPN
fnp-3806	3846	5	regulation	regulation	PROPN
fnp-3806	3846	6	of	of	ADP
fnp-3806	3846	7	alzheimer	alzheimer	PROPN
fnp-3806	3846	8	’s	’s	PART
fnp-3806	3846	9	amyloid	amyloid	NOUN
fnp-3806	3846	10	precursor	precursor	NOUN
fnp-3806	3846	11	protein	protein	NOUN
fnp-3806	3846	12	expression	expression	NOUN
fnp-3806	3846	13	.	.	PUNCT
fnp-3806	3847	1	neurobiol	neurobiol	PROPN
fnp-3806	3847	2	dis	dis	PROPN
fnp-3806	3847	3	2009;33:422	2009;33:422	NUM
fnp-3806	3847	4	-	-	SYM
fnp-3806	3847	5	428	428	NUM
fnp-3806	3847	6	.	.	PUNCT
fnp-3806	3848	1	https://doi.org/10.1016/j.nbd.2008.11.009	https://doi.org/10.1016/j.nbd.2008.11.009	PROPN
fnp-3806	3848	2	hébert	hébert	PROPN
fnp-3806	3848	3	ss	ss	PROPN
fnp-3806	3848	4	,	,	PUNCT
fnp-3806	3848	5	horré	horré	PROPN
fnp-3806	3848	6	k	k	PROPN
fnp-3806	3848	7	,	,	PUNCT
fnp-3806	3848	8	nicolai	nicolai	PROPN
fnp-3806	3848	9	l	l	PROPN
fnp-3806	3848	10	,	,	PUNCT
fnp-3806	3848	11	et	et	PROPN
fnp-3806	3848	12	al	al	PROPN
fnp-3806	3848	13	.	.	PUNCT
fnp-3806	3848	14	loss	loss	PROPN
fnp-3806	3848	15	of	of	ADP
fnp-3806	3848	16	microrna	microrna	PROPN
fnp-3806	3848	17	cluster	cluster	PROPN
fnp-3806	3848	18	mir-29a	mir-29a	NUM
fnp-3806	3848	19	/	/	SYM
fnp-3806	3848	20	b-1	b-1	PROPN
fnp-3806	3848	21	in	in	ADP
fnp-3806	3848	22	sporadic	sporadic	ADJ
fnp-3806	3848	23	alzheimer	alzheimer	PROPN
fnp-3806	3848	24	’s	’s	PART
fnp-3806	3848	25	disease	disease	NOUN
fnp-3806	3848	26	correlates	correlate	VERB
fnp-3806	3848	27	with	with	ADP
fnp-3806	3848	28	increased	increase	VERB
fnp-3806	3848	29	bace1	bace1	NOUN
fnp-3806	3848	30	/	/	SYM
fnp-3806	3848	31	β	β	NOUN
fnp-3806	3848	32	-	-	ADJ
fnp-3806	3848	33	secretase	secretase	ADJ
fnp-3806	3848	34	expression	expression	NOUN
fnp-3806	3848	35	.	.	PUNCT
fnp-3806	3849	1	proc	proc	PROPN
fnp-3806	3849	2	natl	natl	PROPN
fnp-3806	3849	3	acad	acad	PROPN
fnp-3806	3849	4	sci	sci	PROPN
fnp-3806	3849	5	usa	usa	PROPN
fnp-3806	3849	6	2008;105	2008;105	NUM
fnp-3806	3849	7	,	,	PUNCT
fnp-3806	3849	8	6415	6415	NUM
fnp-3806	3849	9	-	-	SYM
fnp-3806	3849	10	6420	6420	NUM
fnp-3806	3849	11	.	.	PUNCT
fnp-3806	3850	1	https://doi.org/10.1073/pnas.0710263105	https://doi.org/10.1073/pnas.0710263105	PROPN
fnp-3806	3850	2	patel	patel	PROPN
fnp-3806	3850	3	n	n	CCONJ
fnp-3806	3850	4	,	,	PUNCT
fnp-3806	3850	5	hoang	hoang	PROPN
fnp-3806	3850	6	d	d	PROPN
fnp-3806	3850	7	,	,	PUNCT
fnp-3806	3850	8	miller	miller	PROPN
fnp-3806	3850	9	n	n	CCONJ
fnp-3806	3850	10	,	,	PUNCT
fnp-3806	3850	11	et	et	PROPN
fnp-3806	3850	12	al	al	PROPN
fnp-3806	3850	13	.	.	PROPN
fnp-3806	3850	14	micrornas	microrna	NOUN
fnp-3806	3850	15	can	can	AUX
fnp-3806	3850	16	regulate	regulate	VERB
fnp-3806	3850	17	human	human	ADJ
fnp-3806	3850	18	app	app	PROPN
fnp-3806	3850	19	levels	level	NOUN
fnp-3806	3850	20	.	.	PUNCT
fnp-3806	3851	1	mol	mol	ADP
fnp-3806	3851	2	neurodegener	neurodegener	NOUN
fnp-3806	3851	3	2008	2008	NUM
fnp-3806	3851	4	;	;	PUNCT
fnp-3806	3851	5	3:10	3:10	NUM
fnp-3806	3851	6	.	.	PUNCT
fnp-3806	3852	1	https://doi.org/10.1186/1750-1326-3-10	https://doi.org/10.1186/1750-1326-3-10	VERB
fnp-3806	3852	2	jarvis	jarvis	PROPN
fnp-3806	3852	3	ci	ci	PROPN
fnp-3806	3852	4	,	,	PUNCT
fnp-3806	3852	5	goncalves	goncalve	NOUN
fnp-3806	3852	6	mb	mb	PROPN
fnp-3806	3852	7	,	,	PUNCT
fnp-3806	3852	8	clarke	clarke	PROPN
fnp-3806	3852	9	e	e	PROPN
fnp-3806	3852	10	,	,	PUNCT
fnp-3806	3852	11	et	et	PROPN
fnp-3806	3852	12	al	al	PROPN
fnp-3806	3852	13	.	.	PUNCT
fnp-3806	3853	1	retinoic	retinoic	PROPN
fnp-3806	3853	2	acid	acid	PROPN
fnp-3806	3853	3	receptor	receptor	NOUN
fnp-3806	3853	4	-	-	PUNCT
fnp-3806	3853	5	alpha	alpha	NOUN
fnp-3806	3853	6	signalling	signal	VERB
fnp-3806	3853	7	antagonizes	antagonize	NOUN
fnp-3806	3853	8	both	both	CCONJ
fnp-3806	3853	9	intracellular	intracellular	ADJ
fnp-3806	3853	10	and	and	CCONJ
fnp-3806	3853	11	extracellular	extracellular	ADJ
fnp-3806	3853	12	amyloid	amyloid	NOUN
fnp-3806	3853	13	-	-	PUNCT
fnp-3806	3853	14	beta	beta	NOUN
fnp-3806	3853	15	production	production	NOUN
fnp-3806	3853	16	and	and	CCONJ
fnp-3806	3853	17	prevents	prevent	VERB
fnp-3806	3853	18	neuronal	neuronal	ADJ
fnp-3806	3853	19	cell	cell	NOUN
fnp-3806	3853	20	death	death	NOUN
fnp-3806	3853	21	caused	cause	VERB
fnp-3806	3853	22	by	by	ADP
fnp-3806	3853	23	amyloid	amyloid	NOUN
fnp-3806	3853	24	-	-	PUNCT
fnp-3806	3853	25	beta	beta	NOUN
fnp-3806	3853	26	.	.	PUNCT
fnp-3806	3854	1	eur	eur	PROPN
fnp-3806	3854	2	j	j	PROPN
fnp-3806	3854	3	neurosci	neurosci	PROPN
fnp-3806	3854	4	2010;32:1246	2010;32:1246	PROPN
fnp-3806	3854	5	-	-	SYM
fnp-3806	3854	6	1255	1255	NUM
fnp-3806	3854	7	.	.	PUNCT
fnp-3806	3855	1	https://doi.org/10.1111/j.1460-9568.2010.07426.x	https://doi.org/10.1111/j.1460-9568.2010.07426.x	ADJ
fnp-3806	3855	2	vilardo	vilardo	PROPN
fnp-3806	3855	3	e	e	NOUN
fnp-3806	3855	4	,	,	PUNCT
fnp-3806	3855	5	barbato	barbato	PROPN
fnp-3806	3855	6	c	c	PROPN
fnp-3806	3855	7	,	,	PUNCT
fnp-3806	3855	8	ciotti	ciotti	PROPN
fnp-3806	3855	9	m	m	PROPN
fnp-3806	3855	10	,	,	PUNCT
fnp-3806	3855	11	et	et	PROPN
fnp-3806	3855	12	al	al	PROPN
fnp-3806	3855	13	.	.	PROPN
fnp-3806	3856	1	microrna-101	microrna-101	PROPN
fnp-3806	3856	2	regulates	regulate	VERB
fnp-3806	3856	3	amyloid	amyloid	NOUN
fnp-3806	3856	4	precursor	precursor	NOUN
fnp-3806	3856	5	protein	protein	NOUN
fnp-3806	3856	6	expression	expression	NOUN
fnp-3806	3856	7	in	in	ADP
fnp-3806	3856	8	hippocampal	hippocampal	ADJ
fnp-3806	3856	9	neurons	neuron	NOUN
fnp-3806	3856	10	.	.	PUNCT
fnp-3806	3857	1	j	j	PROPN
fnp-3806	3857	2	biol	biol	PROPN
fnp-3806	3857	3	chem	chem	NOUN
fnp-3806	3857	4	2010	2010	NUM
fnp-3806	3857	5	;	;	PUNCT
fnp-3806	3857	6	285	285	NUM
fnp-3806	3857	7	:	:	SYM
fnp-3806	3857	8	18344	18344	NUM
fnp-3806	3857	9	-	-	SYM
fnp-3806	3857	10	18351	18351	NUM
fnp-3806	3857	11	.	.	PUNCT
fnp-3806	3858	1	https://doi.org/10.1074/jbc.m110.112664	https://doi.org/10.1074/jbc.m110.112664	PROPN
fnp-3806	3858	2	liu	liu	PROPN
fnp-3806	3858	3	cg	cg	PROPN
fnp-3806	3858	4	,	,	PUNCT
fnp-3806	3858	5	wang	wang	PROPN
fnp-3806	3858	6	jl	jl	PROPN
fnp-3806	3858	7	,	,	PUNCT
fnp-3806	3858	8	li	li	PROPN
fnp-3806	3858	9	l	l	PROPN
fnp-3806	3858	10	,	,	PUNCT
fnp-3806	3858	11	et	et	PROPN
fnp-3806	3858	12	al	al	PROPN
fnp-3806	3858	13	.	.	PROPN
fnp-3806	3858	14	microrna-384	microrna-384	PROPN
fnp-3806	3858	15	regulates	regulate	VERB
fnp-3806	3858	16	both	both	PRON
fnp-3806	3858	17	amyloid	amyloid	NOUN
fnp-3806	3858	18	precursor	precursor	NOUN
fnp-3806	3858	19	protein	protein	NOUN
fnp-3806	3858	20	and	and	CCONJ
fnp-3806	3858	21	beta	beta	NOUN
fnp-3806	3858	22	-	-	PUNCT
fnp-3806	3858	23	secretase	secretase	NOUN
fnp-3806	3858	24	expression	expression	NOUN
fnp-3806	3858	25	and	and	CCONJ
fnp-3806	3858	26	is	be	AUX
fnp-3806	3858	27	a	a	DET
fnp-3806	3858	28	potential	potential	ADJ
fnp-3806	3858	29	biomarker	biomarker	NOUN
fnp-3806	3858	30	for	for	ADP
fnp-3806	3858	31	alzheimer	alzheimer	PROPN
fnp-3806	3858	32	’s	’s	PART
fnp-3806	3858	33	disease	disease	NOUN
fnp-3806	3858	34	.	.	PUNCT
fnp-3806	3859	1	int	int	PROPN
fnp-3806	3859	2	j	j	PROPN
fnp-3806	3859	3	mol	mol	ADP
fnp-3806	3859	4	med	med	PROPN
fnp-3806	3859	5	2014;34:160	2014;34:160	PROPN
fnp-3806	3859	6	-	-	SYM
fnp-3806	3859	7	166	166	NUM
fnp-3806	3859	8	.	.	PUNCT
fnp-3806	3860	1	https://doi.org/10.3892/ijmm.2014.1780	https://doi.org/10.3892/ijmm.2014.1780	PROPN
fnp-3806	3860	2	liu	liu	PROPN
fnp-3806	3860	3	cg	cg	PROPN
fnp-3806	3860	4	,	,	PUNCT
fnp-3806	3860	5	wang	wang	PROPN
fnp-3806	3860	6	jl	jl	PROPN
fnp-3806	3860	7	,	,	PUNCT
fnp-3806	3860	8	li	li	PROPN
fnp-3806	3860	9	l	l	PROPN
fnp-3806	3860	10	,	,	PUNCT
fnp-3806	3860	11	et	et	PROPN
fnp-3806	3860	12	al	al	PROPN
fnp-3806	3860	13	.	.	PUNCT
fnp-3806	3861	1	microrna-135a	microrna-135a	PROPN
fnp-3806	3861	2	and	and	CCONJ
fnp-3806	3861	3	-200b	-200b	PROPN
fnp-3806	3861	4	,	,	PUNCT
fnp-3806	3861	5	potential	potential	ADJ
fnp-3806	3861	6	biomarkers	biomarker	NOUN
fnp-3806	3861	7	for	for	ADP
fnp-3806	3861	8	alzheimers	alzheimer	NOUN
fnp-3806	3861	9	disease	disease	NOUN
fnp-3806	3861	10	,	,	PUNCT
fnp-3806	3861	11	regulate	regulate	VERB
fnp-3806	3861	12	beta	beta	NOUN
fnp-3806	3861	13	secretase	secretase	NOUN
fnp-3806	3861	14	and	and	CCONJ
fnp-3806	3861	15	amyloid	amyloid	NOUN
fnp-3806	3861	16	precursor	precursor	NOUN
fnp-3806	3861	17	protein	protein	NOUN
fnp-3806	3861	18	.	.	PUNCT
fnp-3806	3862	1	brain	brain	NOUN
fnp-3806	3862	2	res	re	NOUN
fnp-3806	3862	3	2014;1583	2014;1583	NUM
fnp-3806	3862	4	:	:	PUNCT
fnp-3806	3862	5	55	55	NUM
fnp-3806	3862	6	-	-	SYM
fnp-3806	3862	7	64	64	NUM
fnp-3806	3862	8	.	.	PUNCT
fnp-3806	3863	1	https://doi.org/10.1016/j.brainres.2014.04.026	https://doi.org/10.1016/j.brainres.2014.04.026	PROPN
fnp-3806	3863	2	liang	liang	PROPN
fnp-3806	3863	3	c	c	PROPN
fnp-3806	3863	4	,	,	PUNCT
fnp-3806	3863	5	zhu	zhu	PROPN
fnp-3806	3863	6	h	h	NOUN
fnp-3806	3863	7	,	,	PUNCT
fnp-3806	3863	8	xu	xu	PROPN
fnp-3806	3863	9	y	y	PROPN
fnp-3806	3863	10	,	,	PUNCT
fnp-3806	3863	11	et	et	PROPN
fnp-3806	3863	12	al	al	PROPN
fnp-3806	3863	13	.	.	PROPN
fnp-3806	3863	14	microrna-153	microrna-153	PROPN
fnp-3806	3863	15	negatively	negatively	ADV
fnp-3806	3863	16	regulates	regulate	VERB
fnp-3806	3863	17	the	the	DET
fnp-3806	3863	18	expression	expression	NOUN
fnp-3806	3863	19	of	of	ADP
fnp-3806	3863	20	amyloid	amyloid	NOUN
fnp-3806	3863	21	precursor	precursor	NOUN
fnp-3806	3863	22	protein	protein	NOUN
fnp-3806	3863	23	and	and	CCONJ
fnp-3806	3863	24	amyloid	amyloid	NOUN
fnp-3806	3863	25	precursor	precursor	NOUN
fnp-3806	3863	26	-	-	PUNCT
fnp-3806	3863	27	like	like	ADJ
fnp-3806	3863	28	protein	protein	NOUN
fnp-3806	3863	29	2	2	NUM
fnp-3806	3863	30	.	.	PUNCT
fnp-3806	3863	31	brain	brain	NOUN
fnp-3806	3863	32	res	re	NOUN
fnp-3806	3863	33	2012;1455	2012;1455	NUM
fnp-3806	3863	34	:	:	PUNCT
fnp-3806	3863	35	103	103	NUM
fnp-3806	3863	36	-	-	SYM
fnp-3806	3863	37	113	113	NUM
fnp-3806	3863	38	.	.	PUNCT
fnp-3806	3864	1	https://doi.org/10.1016/j.brainres.2011.10.051	https://doi.org/10.1016/j.brainres.2011.10.051	VERB
fnp-3806	3864	2	long	long	ADJ
fnp-3806	3864	3	jm	jm	PROPN
fnp-3806	3864	4	,	,	PUNCT
fnp-3806	3864	5	ray	ray	PROPN
fnp-3806	3864	6	b	b	PROPN
fnp-3806	3864	7	,	,	PUNCT
fnp-3806	3864	8	lahiri	lahiri	PROPN
fnp-3806	3864	9	dk	dk	PROPN
fnp-3806	3864	10	.	.	PROPN
fnp-3806	3864	11	microrna-153	microrna-153	PROPN
fnp-3806	3864	12	physiologically	physiologically	ADV
fnp-3806	3864	13	inhibits	inhibit	VERB
fnp-3806	3864	14	expression	expression	NOUN
fnp-3806	3864	15	of	of	ADP
fnp-3806	3864	16	amyloid	amyloid	NOUN
fnp-3806	3864	17	-	-	PUNCT
fnp-3806	3864	18	beta	beta	NOUN
fnp-3806	3864	19	precursor	precursor	NOUN
fnp-3806	3864	20	protein	protein	NOUN
fnp-3806	3864	21	in	in	ADP
fnp-3806	3864	22	cultured	cultured	ADJ
fnp-3806	3864	23	human	human	ADJ
fnp-3806	3864	24	fetal	fetal	ADJ
fnp-3806	3864	25	brain	brain	NOUN
fnp-3806	3864	26	cells	cell	NOUN
fnp-3806	3864	27	and	and	CCONJ
fnp-3806	3864	28	is	be	AUX
fnp-3806	3864	29	dysregulated	dysregulate	VERB
fnp-3806	3864	30	in	in	ADP
fnp-3806	3864	31	a	a	DET
fnp-3806	3864	32	subset	subset	NOUN
fnp-3806	3864	33	of	of	ADP
fnp-3806	3864	34	alzheimer	alzheimer	PROPN
fnp-3806	3864	35	disease	disease	NOUN
fnp-3806	3864	36	patients	patient	NOUN
fnp-3806	3864	37	.	.	PUNCT
fnp-3806	3865	1	j	j	PROPN
fnp-3806	3865	2	biol	biol	PROPN
fnp-3806	3865	3	chem	chem	NOUN
fnp-3806	3865	4	2012;287	2012;287	NUM
fnp-3806	3865	5	:	:	PUNCT
fnp-3806	3865	6	31298	31298	NUM
fnp-3806	3865	7	-	-	SYM
fnp-3806	3865	8	31310	31310	NUM
fnp-3806	3865	9	.	.	PUNCT
fnp-3806	3866	1	https://doi.org/10.1074/jbc.m112.366336	https://doi.org/10.1074/jbc.m112.366336	PROPN
fnp-3806	3866	2	long	long	PROPN
fnp-3806	3866	3	jm	jm	PROPN
fnp-3806	3866	4	,	,	PUNCT
fnp-3806	3866	5	ray	ray	PROPN
fnp-3806	3866	6	b	b	PROPN
fnp-3806	3866	7	,	,	PUNCT
fnp-3806	3866	8	lahiri	lahiri	PROPN
fnp-3806	3866	9	dk	dk	PROPN
fnp-3806	3866	10	.	.	PROPN
fnp-3806	3866	11	microrna-339	microrna-339	PROPN
fnp-3806	3866	12	-	-	PUNCT
fnp-3806	3866	13	5p	5p	NOUN
fnp-3806	3866	14	down	down	ADP
fnp-3806	3866	15	-	-	PUNCT
fnp-3806	3866	16	regulates	regulate	VERB
fnp-3806	3866	17	protein	protein	NOUN
fnp-3806	3866	18	expression	expression	NOUN
fnp-3806	3866	19	of	of	ADP
fnp-3806	3866	20	beta	beta	NOUN
fnp-3806	3866	21	-	-	PUNCT
fnp-3806	3866	22	site	site	NOUN
fnp-3806	3866	23	amyloid	amyloid	NOUN
fnp-3806	3866	24	precursor	precursor	NOUN
fnp-3806	3866	25	protein	protein	NOUN
fnp-3806	3866	26	-	-	PUNCT
fnp-3806	3866	27	cleaving	cleave	VERB
fnp-3806	3866	28	enzyme	enzyme	NOUN
fnp-3806	3866	29	1	1	NUM
fnp-3806	3866	30	(	(	PUNCT
fnp-3806	3866	31	bace1	bace1	NOUN
fnp-3806	3866	32	)	)	PUNCT
fnp-3806	3866	33	in	in	ADP
fnp-3806	3866	34	human	human	ADJ
fnp-3806	3866	35	primary	primary	ADJ
fnp-3806	3866	36	brain	brain	NOUN
fnp-3806	3866	37	cultures	culture	NOUN
fnp-3806	3866	38	and	and	CCONJ
fnp-3806	3866	39	is	be	AUX
fnp-3806	3866	40	reduced	reduce	VERB
fnp-3806	3866	41	in	in	ADP
fnp-3806	3866	42	brain	brain	NOUN
fnp-3806	3866	43	tissue	tissue	NOUN
fnp-3806	3866	44	specimens	specimen	NOUN
fnp-3806	3866	45	of	of	ADP
fnp-3806	3866	46	alzheimer	alzheimer	PROPN
fnp-3806	3866	47	disease	disease	NOUN
fnp-3806	3866	48	subjects	subject	NOUN
fnp-3806	3866	49	.	.	PUNCT
fnp-3806	3867	1	j	j	PROPN
fnp-3806	3867	2	biol	biol	PROPN
fnp-3806	3867	3	chem	chem	NOUN
fnp-3806	3867	4	2014	2014	NUM
fnp-3806	3867	5	;	;	PUNCT
fnp-3806	3867	6	289	289	NUM
fnp-3806	3867	7	:	:	PUNCT
fnp-3806	3867	8	5184	5184	NUM
fnp-3806	3867	9	-	-	SYM
fnp-3806	3867	10	5198	5198	NUM
fnp-3806	3867	11	.	.	PUNCT
fnp-3806	3868	1	https://doi.org/10.1074/jbc.m113.518241	https://doi.org/10.1074/jbc.m113.518241	PROPN
fnp-3806	3868	2	cheng	cheng	PROPN
fnp-3806	3868	3	c	c	PROPN
fnp-3806	3868	4	,	,	PUNCT
fnp-3806	3868	5	li	li	PROPN
fnp-3806	3868	6	w	w	PROPN
fnp-3806	3868	7	,	,	PUNCT
fnp-3806	3868	8	zhang	zhang	PROPN
fnp-3806	3868	9	z	z	PROPN
fnp-3806	3868	10	,	,	PUNCT
fnp-3806	3868	11	et	et	PROPN
fnp-3806	3868	12	al	al	PROPN
fnp-3806	3868	13	.	.	PROPN
fnp-3806	3869	1	microrna-144	microrna-144	PROPN
fnp-3806	3869	2	is	be	AUX
fnp-3806	3869	3	regulated	regulate	VERB
fnp-3806	3869	4	by	by	ADP
fnp-3806	3869	5	activator	activator	NOUN
fnp-3806	3869	6	protein-1	protein-1	PROPN
fnp-3806	3869	7	(	(	PUNCT
fnp-3806	3869	8	ap-1	ap-1	ADV
fnp-3806	3869	9	)	)	PUNCT
fnp-3806	3869	10	and	and	CCONJ
fnp-3806	3869	11	decreases	decrease	VERB
fnp-3806	3869	12	expression	expression	NOUN
fnp-3806	3869	13	of	of	ADP
fnp-3806	3869	14	alzheimer	alzheimer	PROPN
fnp-3806	3869	15	disease	disease	NOUN
fnp-3806	3869	16	-	-	PUNCT
fnp-3806	3869	17	related	relate	VERB
fnp-3806	3869	18	a	a	DET
fnp-3806	3869	19	disintegrin	disintegrin	NOUN
fnp-3806	3869	20	and	and	CCONJ
fnp-3806	3869	21	metalloprotease	metalloprotease	NOUN
fnp-3806	3869	22	10	10	NUM
fnp-3806	3869	23	(	(	PUNCT
fnp-3806	3869	24	adam10	adam10	X
fnp-3806	3869	25	)	)	PUNCT
fnp-3806	3869	26	.	.	PUNCT
fnp-3806	3870	1	j	j	PROPN
fnp-3806	3870	2	biol	biol	PROPN
fnp-3806	3870	3	chem	chem	NOUN
fnp-3806	3870	4	2013;288:13748	2013;288:13748	NUM
fnp-3806	3870	5	-	-	PUNCT
fnp-3806	3870	6	13761	13761	NUM
fnp-3806	3870	7	.	.	PUNCT
fnp-3806	3871	1	https://doi.org/10.1074/jbc.m112.381392	https://doi.org/10.1074/jbc.m112.381392	PROPN
fnp-3806	3871	2	deng	deng	PROPN
fnp-3806	3871	3	y	y	PROPN
fnp-3806	3871	4	,	,	PUNCT
fnp-3806	3871	5	ding	de	VERB
fnp-3806	3871	6	y	y	PROPN
fnp-3806	3871	7	,	,	PUNCT
fnp-3806	3871	8	hou	hou	PROPN
fnp-3806	3871	9	d.	d.	PROPN
fnp-3806	3871	10	research	research	PROPN
fnp-3806	3871	11	status	status	NOUN
fnp-3806	3871	12	of	of	ADP
fnp-3806	3871	13	the	the	DET
fnp-3806	3871	14	regulation	regulation	NOUN
fnp-3806	3871	15	of	of	ADP
fnp-3806	3871	16	mirna	mirna	NOUN
fnp-3806	3871	17	on	on	ADP
fnp-3806	3871	18	bace1	bace1	PROPN
fnp-3806	3871	19	.	.	PUNCT
fnp-3806	3872	1	int	int	PROPN
fnp-3806	3872	2	j	j	PROPN
fnp-3806	3872	3	neurosci	neurosci	PROPN
fnp-3806	3872	4	2014;124:474	2014;124:474	NUM
fnp-3806	3872	5	-	-	SYM
fnp-3806	3872	6	477	477	NUM
fnp-3806	3872	7	.	.	PUNCT
fnp-3806	3873	1	https://doi.org/10.3109/00207454.2013.858249	https://doi.org/10.3109/00207454.2013.858249	PROPN
fnp-3806	3873	2	lei	lei	PROPN
fnp-3806	3873	3	x	x	PROPN
fnp-3806	3873	4	,	,	PUNCT
fnp-3806	3873	5	lei	lei	PROPN
fnp-3806	3873	6	l	l	PROPN
fnp-3806	3873	7	,	,	PUNCT
fnp-3806	3873	8	zhang	zhang	PROPN
fnp-3806	3873	9	z	z	PROPN
fnp-3806	3873	10	,	,	PUNCT
fnp-3806	3873	11	et	et	PROPN
fnp-3806	3873	12	al	al	PROPN
fnp-3806	3873	13	.	.	PROPN
fnp-3806	3873	14	downregulated	downregulate	VERB
fnp-3806	3873	15	mir-29c	mir-29c	NUM
fnp-3806	3873	16	correlates	correlate	VERB
fnp-3806	3873	17	with	with	ADP
fnp-3806	3873	18	increased	increase	VERB
fnp-3806	3873	19	bace1	bace1	NOUN
fnp-3806	3873	20	expression	expression	NOUN
fnp-3806	3873	21	in	in	ADP
fnp-3806	3873	22	sporadic	sporadic	ADJ
fnp-3806	3873	23	alzheimer	alzheimer	PROPN
fnp-3806	3873	24	’s	’s	PART
fnp-3806	3873	25	disease	disease	NOUN
fnp-3806	3873	26	.	.	PUNCT
fnp-3806	3874	1	int	int	PROPN
fnp-3806	3875	1	j	j	PROPN
fnp-3806	3875	2	clin	clin	PROPN
fnp-3806	3875	3	exp	exp	PROPN
fnp-3806	3875	4	pathol	pathol	NOUN
fnp-3806	3875	5	2015;8:1565	2015;8:1565	NOUN
fnp-3806	3875	6	-	-	SYM
fnp-3806	3875	7	1574	1574	NUM
fnp-3806	3875	8	.	.	PUNCT
fnp-3806	3876	1	pmid	pmid	NOUN
fnp-3806	3876	2	:	:	PUNCT
fnp-3806	3876	3	25973041	25973041	NUM
fnp-3806	3876	4	.	.	PUNCT
fnp-3806	3877	1	li	li	PROPN
fnp-3806	3877	2	q	q	PROPN
fnp-3806	3877	3	,	,	PUNCT
fnp-3806	3877	4	li	li	PROPN
fnp-3806	3877	5	x	x	PROPN
fnp-3806	3877	6	,	,	PUNCT
fnp-3806	3877	7	wang	wang	PROPN
fnp-3806	3877	8	l	l	PROPN
fnp-3806	3877	9	,	,	PUNCT
fnp-3806	3877	10	et	et	PROPN
fnp-3806	3877	11	al	al	PROPN
fnp-3806	3877	12	.	.	PUNCT
fnp-3806	3878	1	mir-98	mir-98	PROPN
fnp-3806	3878	2	-	-	PUNCT
fnp-3806	3878	3	5p	5p	NUM
fnp-3806	3878	4	acts	act	NOUN
fnp-3806	3878	5	as	as	ADP
fnp-3806	3878	6	a	a	DET
fnp-3806	3878	7	target	target	NOUN
fnp-3806	3878	8	for	for	ADP
fnp-3806	3878	9	alzheimer	alzheimer	PROPN
fnp-3806	3878	10	’s	’s	PART
fnp-3806	3878	11	disease	disease	NOUN
fnp-3806	3878	12	by	by	ADP
fnp-3806	3878	13	regulating	regulate	VERB
fnp-3806	3878	14	aβ	aβ	DET
fnp-3806	3878	15	production	production	NOUN
fnp-3806	3878	16	through	through	ADP
fnp-3806	3878	17	modulating	modulate	VERB
fnp-3806	3878	18	snx6	snx6	NOUN
fnp-3806	3878	19	expression	expression	NOUN
fnp-3806	3878	20	.	.	PUNCT
fnp-3806	3879	1	j	j	PROPN
fnp-3806	3879	2	mol	mol	PROPN
fnp-3806	3879	3	neurosci	neurosci	PROPN
fnp-3806	3879	4	2016	2016	NUM
fnp-3806	3879	5	;	;	PUNCT
fnp-3806	3879	6	60:413	60:413	NUM
fnp-3806	3879	7	-	-	SYM
fnp-3806	3879	8	420	420	NUM
fnp-3806	3879	9	.	.	PUNCT
fnp-3806	3880	1	https://doi.org/10.1007/s12031-016-0815-7	https://doi.org/10.1007/s12031-016-0815-7	NUM
fnp-3806	3880	2	li	li	PROPN
fnp-3806	3880	3	w	w	PROPN
fnp-3806	3880	4	,	,	PUNCT
fnp-3806	3880	5	li	li	PROPN
fnp-3806	3880	6	x	x	PROPN
fnp-3806	3880	7	,	,	PUNCT
fnp-3806	3880	8	xin	xin	PROPN
fnp-3806	3880	9	x	x	PROPN
fnp-3806	3880	10	,	,	PUNCT
fnp-3806	3880	11	et	et	PROPN
fnp-3806	3880	12	al	al	PROPN
fnp-3806	3880	13	.	.	PROPN
fnp-3806	3881	1	microrna-613	microrna-613	PROPN
fnp-3806	3881	2	regulates	regulate	VERB
fnp-3806	3881	3	the	the	DET
fnp-3806	3881	4	expression	expression	NOUN
fnp-3806	3881	5	of	of	ADP
fnp-3806	3881	6	brain	brain	NOUN
fnp-3806	3881	7	-	-	PUNCT
fnp-3806	3881	8	derived	derive	VERB
fnp-3806	3881	9	neurotrophic	neurotrophic	ADJ
fnp-3806	3881	10	factor	factor	NOUN
fnp-3806	3881	11	in	in	ADP
fnp-3806	3881	12	alzheimer	alzheimer	PROPN
fnp-3806	3881	13	’s	’s	PART
fnp-3806	3881	14	disease	disease	NOUN
fnp-3806	3881	15	.	.	PUNCT
fnp-3806	3882	1	biosci	biosci	PROPN
fnp-3806	3882	2	trends	trend	VERB
fnp-3806	3882	3	2016;10	2016;10	NOUN
fnp-3806	3882	4	:	:	PUNCT
fnp-3806	3882	5	372	372	NUM
fnp-3806	3882	6	-	-	SYM
fnp-3806	3882	7	377	377	NUM
fnp-3806	3882	8	.	.	PUNCT
fnp-3806	3883	1	https://doi.org/10.5582/bst.2016.01127	https://doi.org/10.5582/bst.2016.01127	NOUN
fnp-3806	3883	2	kim	kim	PROPN
fnp-3806	3883	3	j	j	PROPN
fnp-3806	3883	4	,	,	PUNCT
fnp-3806	3883	5	yoon	yoon	PROPN
fnp-3806	3883	6	h	h	PROPN
fnp-3806	3883	7	,	,	PUNCT
fnp-3806	3883	8	chung	chung	PROPN
fnp-3806	3883	9	de	de	PROPN
fnp-3806	3883	10	,	,	PUNCT
fnp-3806	3883	11	et	et	PROPN
fnp-3806	3883	12	al	al	PROPN
fnp-3806	3883	13	.	.	PROPN
fnp-3806	3883	14	mir-186	mir-186	PROPN
fnp-3806	3883	15	is	be	AUX
fnp-3806	3883	16	decreased	decrease	VERB
fnp-3806	3883	17	in	in	ADP
fnp-3806	3883	18	aged	aged	ADJ
fnp-3806	3883	19	brain	brain	NOUN
fnp-3806	3883	20	and	and	CCONJ
fnp-3806	3883	21	suppresses	suppress	VERB
fnp-3806	3883	22	bace1	bace1	NOUN
fnp-3806	3883	23	expression	expression	NOUN
fnp-3806	3883	24	.	.	PUNCT
fnp-3806	3884	1	j	j	PROPN
fnp-3806	3884	2	neurochem	neurochem	PROPN
fnp-3806	3884	3	2016;137	2016;137	NUM
fnp-3806	3884	4	:	:	PUNCT
fnp-3806	3884	5	436	436	NUM
fnp-3806	3884	6	-	-	SYM
fnp-3806	3884	7	445	445	NUM
fnp-3806	3884	8	.	.	PUNCT
fnp-3806	3885	1	https://doi.org/10.1111/jnc.13507	https://doi.org/10.1111/jnc.13507	VERB
fnp-3806	3885	2	an	an	DET
fnp-3806	3885	3	f	f	NOUN
fnp-3806	3885	4	,	,	PUNCT
fnp-3806	3885	5	gong	gong	NOUN
fnp-3806	3885	6	g	g	PROPN
fnp-3806	3885	7	,	,	PUNCT
fnp-3806	3885	8	wang	wang	PROPN
fnp-3806	3885	9	y	y	PROPN
fnp-3806	3885	10	,	,	PUNCT
fnp-3806	3885	11	et	et	PROPN
fnp-3806	3885	12	al	al	PROPN
fnp-3806	3885	13	.	.	PROPN
fnp-3806	3885	14	mir-124	mir-124	PROPN
fnp-3806	3885	15	acts	act	VERB
fnp-3806	3885	16	as	as	ADP
fnp-3806	3885	17	a	a	DET
fnp-3806	3885	18	target	target	NOUN
fnp-3806	3885	19	for	for	ADP
fnp-3806	3885	20	alzheimer	alzheimer	PROPN
fnp-3806	3885	21	’s	’s	PART
fnp-3806	3885	22	disease	disease	NOUN
fnp-3806	3885	23	by	by	ADP
fnp-3806	3885	24	regulating	regulate	VERB
fnp-3806	3885	25	bace1	bace1	PROPN
fnp-3806	3885	26	.	.	PUNCT
fnp-3806	3886	1	oncotarget	oncotarget	PROPN
fnp-3806	3886	2	2017;8:114065	2017;8:114065	PROPN
fnp-3806	3886	3	-	-	SYM
fnp-3806	3886	4	114071	114071	NUM
fnp-3806	3886	5	.	.	PUNCT
fnp-3806	3887	1	https://doi.org/10.18632/oncotarget.23119	https://doi.org/10.18632/oncotarget.23119	PROPN
fnp-3806	3887	2	gong	gong	VERB
fnp-3806	3887	3	g	g	PROPN
fnp-3806	3887	4	,	,	PUNCT
fnp-3806	3887	5	an	an	DET
fnp-3806	3887	6	f	f	NOUN
fnp-3806	3887	7	,	,	PUNCT
fnp-3806	3887	8	wang	wang	PROPN
fnp-3806	3887	9	y	y	PROPN
fnp-3806	3887	10	et	et	PROPN
fnp-3806	3887	11	al	al	PROPN
fnp-3806	3887	12	.	.	PROPN
fnp-3806	3887	13	mir-15b	mir-15b	NOUN
fnp-3806	3887	14	represses	repress	VERB
fnp-3806	3887	15	bace1	bace1	NOUN
fnp-3806	3887	16	expression	expression	NOUN
fnp-3806	3887	17	in	in	ADP
fnp-3806	3887	18	sporadic	sporadic	ADJ
fnp-3806	3887	19	alzheimer	alzheimer	PROPN
fnp-3806	3887	20	's	's	PART
fnp-3806	3887	21	disease	disease	NOUN
fnp-3806	3887	22	.	.	PUNCT
fnp-3806	3888	1	oncotarget	oncotarget	PROPN
fnp-3806	3888	2	2017;8:91551	2017;8:91551	PROPN
fnp-3806	3888	3	-	-	PUNCT
fnp-3806	3888	4	91557	91557	NUM
fnp-3806	3888	5	.	.	PUNCT
fnp-3806	3889	1	https://doi.org/10.18632/oncotarget.21177	https://doi.org/10.18632/oncotarget.21177	PROPN
fnp-3806	3889	2	chopra	chopra	PROPN
fnp-3806	3889	3	n	n	CCONJ
fnp-3806	3889	4	,	,	PUNCT
fnp-3806	3889	5	wang	wang	PROPN
fnp-3806	3889	6	r	r	PROPN
fnp-3806	3889	7	,	,	PUNCT
fnp-3806	3889	8	maloney	maloney	PROPN
fnp-3806	3889	9	b	b	PROPN
fnp-3806	3889	10	,	,	PUNCT
fnp-3806	3889	11	et	et	PROPN
fnp-3806	3889	12	al	al	PROPN
fnp-3806	3889	13	.	.	PROPN
fnp-3806	3889	14	microrna-298	microrna-298	PROPN
fnp-3806	3889	15	reduces	reduce	VERB
fnp-3806	3889	16	levels	level	NOUN
fnp-3806	3889	17	of	of	ADP
fnp-3806	3889	18	human	human	ADJ
fnp-3806	3889	19	amyloid	amyloid	NOUN
fnp-3806	3889	20	-	-	PUNCT
fnp-3806	3889	21	beta	beta	NOUN
fnp-3806	3889	22	precursor	precursor	NOUN
fnp-3806	3889	23	protein	protein	NOUN
fnp-3806	3889	24	(	(	PUNCT
fnp-3806	3889	25	app	app	NOUN
fnp-3806	3889	26	)	)	PUNCT
fnp-3806	3889	27	,	,	PUNCT
fnp-3806	3889	28	beta	beta	NOUN
fnp-3806	3889	29	-	-	PUNCT
fnp-3806	3889	30	site	site	NOUN
fnp-3806	3889	31	app	app	NOUN
fnp-3806	3889	32	-	-	PUNCT
fnp-3806	3889	33	converting	convert	VERB
fnp-3806	3889	34	enzyme	enzyme	NOUN
fnp-3806	3889	35	1	1	NUM
fnp-3806	3889	36	(	(	PUNCT
fnp-3806	3889	37	bace1	bace1	NOUN
fnp-3806	3889	38	)	)	PUNCT
fnp-3806	3889	39	and	and	CCONJ
fnp-3806	3889	40	specific	specific	ADJ
fnp-3806	3889	41	tau	tau	PROPN
fnp-3806	3889	42	protein	protein	NOUN
fnp-3806	3889	43	moieties	moiety	NOUN
fnp-3806	3889	44	.	.	PUNCT
fnp-3806	3890	1	mol	mol	ADP
fnp-3806	3890	2	psychiatry	psychiatry	NOUN
fnp-3806	3890	3	2020;26	2020;26	NUM
fnp-3806	3890	4	:	:	PUNCT
fnp-3806	3890	5	5636	5636	NUM
fnp-3806	3890	6	-	-	SYM
fnp-3806	3890	7	5657	5657	NUM
fnp-3806	3890	8	.	.	PUNCT
fnp-3806	3891	1	https://doi.org/10.1038/s41380-019-0610-2	https://doi.org/10.1038/s41380-019-0610-2	PROPN
fnp-3806	3891	2	zhu	zhu	PROPN
fnp-3806	3891	3	hc	hc	PROPN
fnp-3806	3891	4	,	,	PUNCT
fnp-3806	3891	5	wang	wang	PROPN
fnp-3806	3891	6	lm	lm	PROPN
fnp-3806	3891	7	,	,	PUNCT
fnp-3806	3891	8	wang	wang	PROPN
fnp-3806	3891	9	m	m	PROPN
fnp-3806	3891	10	,	,	PUNCT
fnp-3806	3891	11	et	et	PROPN
fnp-3806	3891	12	al	al	PROPN
fnp-3806	3891	13	.	.	PROPN
fnp-3806	3891	14	microrna-195	microrna-195	PROPN
fnp-3806	3891	15	downregulates	downregulates	PROPN
fnp-3806	3891	16	alzheimer	alzheimer	PROPN
fnp-3806	3891	17	’s	’s	PART
fnp-3806	3891	18	disease	disease	NOUN
fnp-3806	3891	19	amyloid	amyloid	NOUN
fnp-3806	3891	20	-	-	PUNCT
fnp-3806	3891	21	beta	beta	NOUN
fnp-3806	3891	22	production	production	NOUN
fnp-3806	3891	23	by	by	ADP
fnp-3806	3891	24	targeting	target	VERB
fnp-3806	3891	25	bace1	bace1	PROPN
fnp-3806	3891	26	.	.	PUNCT
fnp-3806	3892	1	brain	brain	NOUN
fnp-3806	3892	2	res	re	NOUN
fnp-3806	3892	3	bull	bull	NOUN
fnp-3806	3892	4	2012;88:596	2012;88:596	NOUN
fnp-3806	3892	5	-	-	SYM
fnp-3806	3892	6	601	601	NUM
fnp-3806	3892	7	.	.	PUNCT
fnp-3806	3893	1	https://doi.org/10.1016/j.brainresbull.2012.05.018	https://doi.org/10.1016/j.brainresbull.2012.05.018	NOUN
fnp-3806	3893	2	zhu	zhu	PROPN
fnp-3806	3893	3	qb	qb	PROPN
fnp-3806	3893	4	,	,	PUNCT
fnp-3806	3893	5	unmehopa	unmehopa	PROPN
fnp-3806	3893	6	u	u	PROPN
fnp-3806	3893	7	,	,	PUNCT
fnp-3806	3893	8	bossers	bosser	VERB
fnp-3806	3893	9	k	k	PROPN
fnp-3806	3893	10	,	,	PUNCT
fnp-3806	3893	11	et	et	PROPN
fnp-3806	3893	12	al	al	PROPN
fnp-3806	3893	13	.	.	PROPN
fnp-3806	3893	14	microrna-132	microrna-132	PROPN
fnp-3806	3893	15	and	and	CCONJ
fnp-3806	3893	16	early	early	ADJ
fnp-3806	3893	17	growth	growth	NOUN
fnp-3806	3893	18	response-1	response-1	NUM
fnp-3806	3893	19	in	in	ADP
fnp-3806	3893	20	nucleus	nucleus	ADJ
fnp-3806	3893	21	basalis	basali	NOUN
fnp-3806	3893	22	of	of	ADP
fnp-3806	3893	23	meynert	meynert	NOUN
fnp-3806	3893	24	during	during	ADP
fnp-3806	3893	25	the	the	DET
fnp-3806	3893	26	course	course	NOUN
fnp-3806	3893	27	of	of	ADP
fnp-3806	3893	28	alzheimer	alzheimer	PROPN
fnp-3806	3893	29	’s	’s	PART
fnp-3806	3893	30	disease	disease	NOUN
fnp-3806	3893	31	.	.	PUNCT
fnp-3806	3894	1	brain	brain	NOUN
fnp-3806	3894	2	2016;139	2016;139	NUM
fnp-3806	3894	3	:	:	PUNCT
fnp-3806	3895	1	908	908	NUM
fnp-3806	3895	2	-	-	SYM
fnp-3806	3895	3	921	921	NUM
fnp-3806	3895	4	.	.	PUNCT
fnp-3806	3895	5	https://doi.org/10.1093/brain/awv383	https://doi.org/10.1093/brain/awv383	PROPN
fnp-3806	3895	6	hu	hu	PROPN
fnp-3806	3895	7	yk	yk	PROPN
fnp-3806	3895	8	,	,	PUNCT
fnp-3806	3895	9	wang	wang	PROPN
fnp-3806	3895	10	x	x	PROPN
fnp-3806	3895	11	,	,	PUNCT
fnp-3806	3895	12	li	li	PROPN
fnp-3806	3895	13	l	l	PROPN
fnp-3806	3895	14	,	,	PUNCT
fnp-3806	3895	15	et	et	PROPN
fnp-3806	3895	16	al	al	PROPN
fnp-3806	3895	17	.	.	PUNCT
fnp-3806	3896	1	microrna-98	microrna-98	PROPN
fnp-3806	3896	2	induces	induce	VERB
fnp-3806	3896	3	an	an	DET
fnp-3806	3896	4	alzheimer	alzheimer	NOUN
fnp-3806	3896	5	’s	’s	PART
fnp-3806	3896	6	disease	disease	NOUN
fnp-3806	3896	7	-	-	PUNCT
fnp-3806	3896	8	like	like	ADJ
fnp-3806	3896	9	disturbance	disturbance	NOUN
fnp-3806	3896	10	by	by	ADP
fnp-3806	3896	11	targeting	target	VERB
fnp-3806	3896	12	insulin	insulin	NOUN
fnp-3806	3896	13	-	-	PUNCT
fnp-3806	3896	14	like	like	ADJ
fnp-3806	3896	15	growth	growth	NOUN
fnp-3806	3896	16	factor	factor	NOUN
fnp-3806	3896	17	1	1	NUM
fnp-3806	3896	18	.	.	PUNCT
fnp-3806	3896	19	neurosci	neurosci	PROPN
fnp-3806	3896	20	bull	bull	PROPN
fnp-3806	3896	21	2013;29	2013;29	NUM
fnp-3806	3896	22	:	:	PUNCT
fnp-3806	3896	23	745	745	NUM
fnp-3806	3896	24	-	-	SYM
fnp-3806	3896	25	751	751	NUM
fnp-3806	3896	26	.	.	PUNCT
fnp-3806	3897	1	https://doi.org/10.1007/s12264-013-1348-5	https://doi.org/10.1007/s12264-013-1348-5	PROPN
fnp-3806	3897	2	absalon	absalon	PROPN
fnp-3806	3897	3	s	s	PROPN
fnp-3806	3897	4	,	,	PUNCT
fnp-3806	3897	5	kochanek	kochanek	ADJ
fnp-3806	3897	6	dm	dm	PROPN
fnp-3806	3897	7	,	,	PUNCT
fnp-3806	3897	8	raghavan	raghavan	PROPN
fnp-3806	3897	9	v	v	PROPN
fnp-3806	3897	10	,	,	PUNCT
fnp-3806	3897	11	et	et	PROPN
fnp-3806	3897	12	al	al	PROPN
fnp-3806	3897	13	.	.	PROPN
fnp-3806	3897	14	mir-26b	mir-26b	PROPN
fnp-3806	3897	15	,	,	PUNCT
fnp-3806	3897	16	upregulated	upregulate	VERB
fnp-3806	3897	17	in	in	ADP
fnp-3806	3897	18	alzheimer	alzheimer	PROPN
fnp-3806	3897	19	’s	’s	PART
fnp-3806	3897	20	disease	disease	NOUN
fnp-3806	3897	21	,	,	PUNCT
fnp-3806	3897	22	activates	activate	VERB
fnp-3806	3897	23	cell	cell	NOUN
fnp-3806	3897	24	cycle	cycle	NOUN
fnp-3806	3897	25	entry	entry	NOUN
fnp-3806	3897	26	,	,	PUNCT
fnp-3806	3897	27	tau	tau	NOUN
fnp-3806	3897	28	-	-	PUNCT
fnp-3806	3897	29	phosphorylation	phosphorylation	NOUN
fnp-3806	3897	30	,	,	PUNCT
fnp-3806	3897	31	and	and	CCONJ
fnp-3806	3897	32	apoptosis	apoptosis	NOUN
fnp-3806	3897	33	in	in	ADP
fnp-3806	3897	34	postmitotic	postmitotic	ADJ
fnp-3806	3897	35	neurons	neuron	NOUN
fnp-3806	3897	36	.	.	PUNCT
fnp-3806	3898	1	j	j	PROPN
fnp-3806	3898	2	neurosci	neurosci	PROPN
fnp-3806	3898	3	2013;33:14645	2013;33:14645	NUM
fnp-3806	3898	4	-	-	SYM
fnp-3806	3898	5	14659	14659	NUM
fnp-3806	3898	6	.	.	PUNCT
fnp-3806	3899	1	https://doi.org/10.1523/jneurosci.1327-13.2013	https://doi.org/10.1523/jneurosci.1327-13.2013	PROPN
fnp-3806	3899	2	dickson	dickson	PROPN
fnp-3806	3899	3	jr	jr	PROPN
fnp-3806	3899	4	,	,	PUNCT
fnp-3806	3899	5	kruse	kruse	PROPN
fnp-3806	3899	6	c	c	PROPN
fnp-3806	3899	7	,	,	PUNCT
fnp-3806	3899	8	montagna	montagna	PROPN
fnp-3806	3899	9	dr	dr	PROPN
fnp-3806	3899	10	,	,	PUNCT
fnp-3806	3899	11	et	et	PROPN
fnp-3806	3899	12	al	al	PROPN
fnp-3806	3899	13	.	.	PROPN
fnp-3806	3899	14	alternative	alternative	ADJ
fnp-3806	3899	15	polyadenylation	polyadenylation	NOUN
fnp-3806	3899	16	and	and	CCONJ
fnp-3806	3899	17	mir-34	mir-34	NOUN
fnp-3806	3899	18	family	family	NOUN
fnp-3806	3899	19	members	member	NOUN
fnp-3806	3899	20	regulate	regulate	VERB
fnp-3806	3899	21	tau	tau	NOUN
fnp-3806	3899	22	expression	expression	NOUN
fnp-3806	3899	23	.	.	PUNCT
fnp-3806	3900	1	j	j	PROPN
fnp-3806	3900	2	neurochem	neurochem	PROPN
fnp-3806	3900	3	2013;127:739	2013;127:739	NUM
fnp-3806	3900	4	-	-	SYM
fnp-3806	3900	5	749	749	NUM
fnp-3806	3900	6	.	.	PUNCT
fnp-3806	3901	1	https://doi.org/10.1111/jnc.12437	https://doi.org/10.1111/jnc.12437	PROPN
fnp-3806	3901	2	gong	gong	PROPN
fnp-3806	3901	3	j	j	PROPN
fnp-3806	3901	4	,	,	PUNCT
fnp-3806	3901	5	zhang	zhang	PROPN
fnp-3806	3901	6	j	j	PROPN
fnp-3806	3901	7	,	,	PUNCT
fnp-3806	3901	8	li	li	PROPN
fnp-3806	3901	9	b	b	PROPN
fnp-3806	3901	10	,	,	PUNCT
fnp-3806	3901	11	et	et	PROPN
fnp-3806	3901	12	al	al	PROPN
fnp-3806	3901	13	.	.	PUNCT
fnp-3806	3902	1	microrna-125b	microrna-125b	PROPN
fnp-3806	3902	2	promotes	promote	VERB
fnp-3806	3902	3	apoptosis	apoptosis	NOUN
fnp-3806	3902	4	by	by	ADP
fnp-3806	3902	5	regulating	regulate	VERB
fnp-3806	3902	6	the	the	DET
fnp-3806	3902	7	expression	expression	NOUN
fnp-3806	3902	8	of	of	ADP
fnp-3806	3902	9	mcl-1	mcl-1	PRON
fnp-3806	3902	10	,	,	PUNCT
fnp-3806	3902	11	bcl	bcl	PROPN
fnp-3806	3902	12	-	-	PROPN
fnp-3806	3902	13	w	w	PROPN
fnp-3806	3902	14	and	and	CCONJ
fnp-3806	3902	15	il-6r	il-6r	PROPN
fnp-3806	3902	16	.	.	PUNCT
fnp-3806	3903	1	oncogene	oncogene	NOUN
fnp-3806	3903	2	2013;32:3071	2013;32:3071	PROPN
fnp-3806	3903	3	-	-	SYM
fnp-3806	3903	4	3079	3079	NUM
fnp-3806	3903	5	.	.	PUNCT
fnp-3806	3904	1	https://doi.org/10.1038/onc.2012.318	https://doi.org/10.1038/onc.2012.318	PROPN
fnp-3806	3904	2	zhao	zhao	PROPN
fnp-3806	3904	3	y	y	PROPN
fnp-3806	3904	4	,	,	PUNCT
fnp-3806	3904	5	bhattacharjee	bhattacharjee	PROPN
fnp-3806	3904	6	s	s	PROPN
fnp-3806	3904	7	,	,	PUNCT
fnp-3806	3904	8	jones	jones	PROPN
fnp-3806	3904	9	bm	bm	PROPN
fnp-3806	3904	10	,	,	PUNCT
fnp-3806	3904	11	et	et	PROPN
fnp-3806	3904	12	al	al	PROPN
fnp-3806	3904	13	.	.	PUNCT
fnp-3806	3905	1	regulation	regulation	NOUN
fnp-3806	3905	2	of	of	ADP
fnp-3806	3905	3	neurotropic	neurotropic	NOUN
fnp-3806	3905	4	signaling	signal	VERB
fnp-3806	3905	5	by	by	ADP
fnp-3806	3905	6	the	the	DET
fnp-3806	3905	7	inducible	inducible	ADJ
fnp-3806	3905	8	,	,	PUNCT
fnp-3806	3905	9	nf	nf	ADJ
fnp-3806	3905	10	-	-	PUNCT
fnp-3806	3905	11	κb	κb	NOUN
fnp-3806	3905	12	-	-	PUNCT
fnp-3806	3905	13	sensitive	sensitive	ADJ
fnp-3806	3905	14	mirna-125b	mirna-125b	PROPN
fnp-3806	3905	15	in	in	ADP
fnp-3806	3905	16	alzheimer	alzheimer	PROPN
fnp-3806	3905	17	’s	’s	PART
fnp-3806	3905	18	disease	disease	NOUN
fnp-3806	3905	19	(	(	PUNCT
fnp-3806	3905	20	ad	ad	NOUN
fnp-3806	3905	21	)	)	PUNCT
fnp-3806	3905	22	and	and	CCONJ
fnp-3806	3905	23	in	in	ADP
fnp-3806	3905	24	primary	primary	ADJ
fnp-3806	3905	25	human	human	ADJ
fnp-3806	3905	26	neuronal	neuronal	ADJ
fnp-3806	3905	27	-	-	PUNCT
fnp-3806	3905	28	glial	glial	ADJ
fnp-3806	3905	29	(	(	PUNCT
fnp-3806	3905	30	hng	hng	NOUN
fnp-3806	3905	31	)	)	PUNCT
fnp-3806	3905	32	cells	cell	NOUN
fnp-3806	3905	33	.	.	PUNCT
fnp-3806	3906	1	mol	mol	ADP
fnp-3806	3906	2	neurobiol	neurobiol	PROPN
fnp-3806	3906	3	2014	2014	NUM
fnp-3806	3906	4	;	;	PUNCT
fnp-3806	3906	5	50	50	NUM
fnp-3806	3906	6	:	:	SYM
fnp-3806	3906	7	97	97	NUM
fnp-3806	3906	8	-	-	SYM
fnp-3806	3906	9	106	106	NUM
fnp-3806	3906	10	.	.	PUNCT
fnp-3806	3907	1	https://doi.org/10.1007/s12035-013-8595-3	https://doi.org/10.1007/s12035-013-8595-3	PROPN
fnp-3806	3908	1	zhang	zhang	PROPN
fnp-3806	3908	2	x	x	PROPN
fnp-3806	3908	3	,	,	PUNCT
fnp-3806	3908	4	tan	tan	PROPN
fnp-3806	3908	5	l	l	NOUN
fnp-3806	3908	6	,	,	PUNCT
fnp-3806	3908	7	lu	lu	PROPN
fnp-3806	3908	8	y	y	PROPN
fnp-3806	3908	9	,	,	PUNCT
fnp-3806	3908	10	et	et	PROPN
fnp-3806	3908	11	al	al	PROPN
fnp-3806	3908	12	.	.	PROPN
fnp-3806	3908	13	microrna-138	microrna-138	PROPN
fnp-3806	3908	14	promotes	promote	VERB
fnp-3806	3908	15	tau	tau	PROPN
fnp-3806	3908	16	phosphorylation	phosphorylation	NOUN
fnp-3806	3908	17	by	by	ADP
fnp-3806	3908	18	targeting	target	VERB
fnp-3806	3908	19	retinoic	retinoic	ADJ
fnp-3806	3908	20	acid	acid	NOUN
fnp-3806	3908	21	receptor	receptor	NOUN
fnp-3806	3908	22	alpha	alpha	PROPN
fnp-3806	3908	23	.	.	PUNCT
fnp-3806	3909	1	febs	febs	PROPN
fnp-3806	3909	2	lett	lett	PROPN
fnp-3806	3909	3	2015;589:726	2015;589:726	X
fnp-3806	3909	4	-	-	SYM
fnp-3806	3909	5	729	729	NUM
fnp-3806	3909	6	.	.	PUNCT
fnp-3806	3910	1	https://doi.org/10.1016/j.febslet.2015.02.001	https://doi.org/10.1016/j.febslet.2015.02.001	PROPN
fnp-3806	3910	2	salta	salta	PROPN
fnp-3806	3910	3	e	e	PROPN
fnp-3806	3910	4	,	,	PUNCT
fnp-3806	3910	5	sierksma	sierksma	PROPN
fnp-3806	3910	6	a	a	X
fnp-3806	3910	7	,	,	PUNCT
fnp-3806	3910	8	vanden	vanden	PROPN
fnp-3806	3910	9	eynden	eynden	PROPN
fnp-3806	3910	10	e	e	PROPN
fnp-3806	3910	11	,	,	PUNCT
fnp-3806	3911	1	et	et	PROPN
fnp-3806	3911	2	al	al	PROPN
fnp-3806	3911	3	.	.	PROPN
fnp-3806	3911	4	mir-132	mir-132	PROPN
fnp-3806	3911	5	loss	loss	PROPN
fnp-3806	3911	6	de	de	NOUN
fnp-3806	3911	7	-	-	NOUN
fnp-3806	3911	8	represses	repress	VERB
fnp-3806	3911	9	itpkb	itpkb	NOUN
fnp-3806	3911	10	and	and	CCONJ
fnp-3806	3911	11	aggravates	aggravate	VERB
fnp-3806	3911	12	amyloid	amyloid	NOUN
fnp-3806	3911	13	and	and	CCONJ
fnp-3806	3911	14	tau	tau	PROPN
fnp-3806	3911	15	pathology	pathology	PROPN
fnp-3806	3911	16	in	in	ADP
fnp-3806	3911	17	alzheimer	alzheimer	PROPN
fnp-3806	3911	18	’s	’s	PART
fnp-3806	3911	19	brain	brain	NOUN
fnp-3806	3911	20	.	.	PUNCT
fnp-3806	3912	1	embo	embo	PROPN
fnp-3806	3912	2	mol	mol	ADP
fnp-3806	3912	3	med	med	ADJ
fnp-3806	3912	4	2016;8:1005	2016;8:1005	NUM
fnp-3806	3912	5	-	-	PUNCT
fnp-3806	3912	6	1018	1018	NUM
fnp-3806	3912	7	.	.	PUNCT
fnp-3806	3913	1	https://doi.org/10.15252/emmm.201606520	https://doi.org/10.15252/emmm.201606520	PROPN
fnp-3806	3913	2	edbauer	edbauer	NOUN
fnp-3806	3913	3	d	d	PROPN
fnp-3806	3913	4	,	,	PUNCT
fnp-3806	3913	5	neilson	neilson	PROPN
fnp-3806	3913	6	jr	jr	PROPN
fnp-3806	3913	7	,	,	PUNCT
fnp-3806	3913	8	foster	foster	PROPN
fnp-3806	3913	9	ka	ka	PROPN
fnp-3806	3913	10	,	,	PUNCT
fnp-3806	3913	11	et	et	PROPN
fnp-3806	3913	12	al	al	PROPN
fnp-3806	3913	13	.	.	PUNCT
fnp-3806	3914	1	regulation	regulation	NOUN
fnp-3806	3914	2	of	of	ADP
fnp-3806	3914	3	synaptic	synaptic	ADJ
fnp-3806	3914	4	structure	structure	NOUN
fnp-3806	3914	5	and	and	CCONJ
fnp-3806	3914	6	function	function	NOUN
fnp-3806	3914	7	by	by	ADP
fnp-3806	3914	8	fmrp	fmrp	NOUN
fnp-3806	3914	9	-	-	PUNCT
fnp-3806	3914	10	associated	associate	VERB
fnp-3806	3914	11	micrornas	microrna	NOUN
fnp-3806	3914	12	mir-125b	mir-125b	PROPN
fnp-3806	3914	13	and	and	CCONJ
fnp-3806	3914	14	mir-132	mir-132	PROPN
fnp-3806	3914	15	.	.	PROPN
fnp-3806	3914	16	neuron	neuron	PROPN
fnp-3806	3914	17	2010;65	2010;65	NUM
fnp-3806	3914	18	:	:	PUNCT
fnp-3806	3914	19	373	373	NUM
fnp-3806	3914	20	-	-	SYM
fnp-3806	3914	21	384	384	NUM
fnp-3806	3914	22	.	.	PUNCT
fnp-3806	3915	1	https://doi.org/10.1016/j.neuron.2010.01.005	https://doi.org/10.1016/j.neuron.2010.01.005	PROPN
fnp-3806	3915	2	cohen	cohen	PROPN
fnp-3806	3915	3	je	je	PROPN
fnp-3806	3915	4	,	,	PUNCT
fnp-3806	3915	5	lee	lee	PROPN
fnp-3806	3915	6	pr	pr	PROPN
fnp-3806	3915	7	,	,	PUNCT
fnp-3806	3915	8	chen	chen	PROPN
fnp-3806	3915	9	s	s	PROPN
fnp-3806	3915	10	,	,	PUNCT
fnp-3806	3916	1	et	et	PROPN
fnp-3806	3916	2	al	al	PROPN
fnp-3806	3916	3	.	.	PUNCT
fnp-3806	3916	4	microrna	microrna	PROPN
fnp-3806	3916	5	regulation	regulation	NOUN
fnp-3806	3916	6	of	of	ADP
fnp-3806	3916	7	homeostatic	homeostatic	ADJ
fnp-3806	3916	8	synaptic	synaptic	ADJ
fnp-3806	3916	9	plasticity	plasticity	NOUN
fnp-3806	3916	10	.	.	PUNCT
fnp-3806	3917	1	proc	proc	PROPN
fnp-3806	3917	2	natl	natl	PROPN
fnp-3806	3917	3	acad	acad	PROPN
fnp-3806	3917	4	sci	sci	PROPN
fnp-3806	3917	5	usa	usa	PROPN
fnp-3806	3917	6	2011;108:11650	2011;108:11650	PROPN
fnp-3806	3917	7	-	-	SYM
fnp-3806	3917	8	11655	11655	NUM
fnp-3806	3917	9	.	.	PUNCT
fnp-3806	3918	1	https://doi.org/10.1073/pnas.1017576108	https://doi.org/10.1073/pnas.1017576108	VERB
fnp-3806	3918	2	giusti	giusti	PROPN
fnp-3806	3918	3	sa	sa	PROPN
fnp-3806	3918	4	,	,	PUNCT
fnp-3806	3918	5	vogl	vogl	PROPN
fnp-3806	3918	6	am	be	AUX
fnp-3806	3918	7	,	,	PUNCT
fnp-3806	3918	8	brockmann	brockmann	PROPN
fnp-3806	3918	9	mm	mm	PROPN
fnp-3806	3918	10	,	,	PUNCT
fnp-3806	3918	11	et	et	PROPN
fnp-3806	3918	12	al	al	PROPN
fnp-3806	3918	13	.	.	PUNCT
fnp-3806	3919	1	microrna-9	microrna-9	X
fnp-3806	3919	2	controls	control	VERB
fnp-3806	3919	3	dendritic	dendritic	ADJ
fnp-3806	3919	4	development	development	NOUN
fnp-3806	3919	5	by	by	ADP
fnp-3806	3919	6	targeting	target	VERB
fnp-3806	3919	7	rest	rest	NOUN
fnp-3806	3919	8	.	.	PUNCT
fnp-3806	3920	1	elife	elife	NOUN
fnp-3806	3920	2	2014:3	2014:3	NUM
fnp-3806	3920	3	:	:	PUNCT
fnp-3806	3920	4	e02755	e02755	PROPN
fnp-3806	3920	5	.	.	PUNCT
fnp-3806	3921	1	https://doi.org/10.7554/elife.02755	https://doi.org/10.7554/elife.02755	ADJ
fnp-3806	3921	2	hu	hu	PROPN
fnp-3806	3921	3	z	z	PROPN
fnp-3806	3921	4	,	,	PUNCT
fnp-3806	3921	5	zhao	zhao	PROPN
fnp-3806	3921	6	j	j	PROPN
fnp-3806	3921	7	,	,	PUNCT
fnp-3806	3921	8	hu	hu	PROPN
fnp-3806	3921	9	t	t	PROPN
fnp-3806	3921	10	,	,	PUNCT
fnp-3806	3921	11	et	et	PROPN
fnp-3806	3921	12	al	al	PROPN
fnp-3806	3921	13	.	.	PROPN
fnp-3806	3921	14	mir-501	mir-501	VERB
fnp-3806	3921	15	-	-	PUNCT
fnp-3806	3921	16	3p	3p	NUM
fnp-3806	3921	17	mediates	mediate	NOUN
fnp-3806	3921	18	the	the	DET
fnp-3806	3921	19	activity	activity	NOUN
fnp-3806	3921	20	-	-	PUNCT
fnp-3806	3921	21	dependent	dependent	ADJ
fnp-3806	3921	22	regulation	regulation	NOUN
fnp-3806	3921	23	of	of	ADP
fnp-3806	3921	24	the	the	DET
fnp-3806	3921	25	expression	expression	NOUN
fnp-3806	3921	26	of	of	ADP
fnp-3806	3921	27	ampa	ampa	NOUN
fnp-3806	3921	28	receptor	receptor	NOUN
fnp-3806	3921	29	subunit	subunit	NOUN
fnp-3806	3921	30	glua1	glua1	PROPN
fnp-3806	3921	31	.	.	PUNCT
fnp-3806	3922	1	j	j	PROPN
fnp-3806	3922	2	cell	cell	NOUN
fnp-3806	3922	3	biol	biol	PROPN
fnp-3806	3922	4	2015;208:949	2015;208:949	NUM
fnp-3806	3922	5	-	-	SYM
fnp-3806	3922	6	959	959	NUM
fnp-3806	3922	7	.	.	PUNCT
fnp-3806	3923	1	https://doi.org/10.1083/jcb.201404092	https://doi.org/10.1083/jcb.201404092	PROPN
fnp-3806	3923	2	olde	olde	PROPN
fnp-3806	3923	3	loohuis	loohuis	PROPN
fnp-3806	3923	4	nf	nf	PROPN
fnp-3806	3923	5	,	,	PUNCT
fnp-3806	3923	6	ba	ba	PROPN
fnp-3806	3923	7	w	w	PROPN
fnp-3806	3923	8	,	,	PUNCT
fnp-3806	3923	9	stoerchel	stoerchel	PROPN
fnp-3806	3923	10	ph	ph	PROPN
fnp-3806	3923	11	,	,	PUNCT
fnp-3806	3923	12	et	et	PROPN
fnp-3806	3923	13	al	al	PROPN
fnp-3806	3923	14	.	.	PROPN
fnp-3806	3923	15	microrna-137	microrna-137	PROPN
fnp-3806	3923	16	controls	control	VERB
fnp-3806	3923	17	ampa	ampa	NOUN
fnp-3806	3923	18	-	-	PUNCT
fnp-3806	3923	19	receptor	receptor	NOUN
fnp-3806	3923	20	-	-	PUNCT
fnp-3806	3923	21	mediated	mediate	VERB
fnp-3806	3923	22	transmission	transmission	NOUN
fnp-3806	3923	23	and	and	CCONJ
fnp-3806	3923	24	mglur	mglur	ADJ
fnp-3806	3923	25	-	-	PUNCT
fnp-3806	3923	26	dependent	dependent	PROPN
fnp-3806	3923	27	ltd	ltd	PROPN
fnp-3806	3923	28	.	.	PROPN
fnp-3806	3923	29	cell	cell	PROPN
fnp-3806	3923	30	rep	rep	PROPN
fnp-3806	3923	31	2015;11:1876	2015;11:1876	NUM
fnp-3806	3923	32	-	-	SYM
fnp-3806	3923	33	1884	1884	NUM
fnp-3806	3923	34	.	.	PUNCT
fnp-3806	3924	1	https://doi.org/10.1016/j.celrep.2015.05.040	https://doi.org/10.1016/j.celrep.2015.05.040	NOUN
fnp-3806	3924	2	sim	sim	VERB
fnp-3806	3924	3	se	se	PROPN
fnp-3806	3924	4	,	,	PUNCT
fnp-3806	3924	5	lim	lim	PROPN
fnp-3806	3924	6	cs	cs	PROPN
fnp-3806	3924	7	,	,	PUNCT
fnp-3806	3924	8	kim	kim	PROPN
fnp-3806	3924	9	ji	ji	PROPN
fnp-3806	3924	10	,	,	PUNCT
fnp-3806	3924	11	et	et	PROPN
fnp-3806	3924	12	al	al	PROPN
fnp-3806	3924	13	.	.	PUNCT
fnp-3806	3925	1	the	the	DET
fnp-3806	3925	2	brain	brain	NOUN
fnp-3806	3925	3	-	-	PUNCT
fnp-3806	3925	4	enriched	enrich	VERB
fnp-3806	3925	5	microrna	microrna	PROPN
fnp-3806	3925	6	mir-9	mir-9	NOUN
fnp-3806	3925	7	-	-	PUNCT
fnp-3806	3925	8	3p	3p	NUM
fnp-3806	3925	9	regulates	regulate	VERB
fnp-3806	3925	10	synaptic	synaptic	ADJ
fnp-3806	3925	11	plasticity	plasticity	NOUN
fnp-3806	3925	12	and	and	CCONJ
fnp-3806	3925	13	memory	memory	NOUN
fnp-3806	3925	14	.	.	PUNCT
fnp-3806	3926	1	j	j	PROPN
fnp-3806	3926	2	neurosci	neurosci	PROPN
fnp-3806	3926	3	2016;36:8641	2016;36:8641	PROPN
fnp-3806	3926	4	-	-	SYM
fnp-3806	3926	5	8652	8652	NUM
fnp-3806	3926	6	.	.	PUNCT
fnp-3806	3927	1	https://doi.org/10.1523/jneurosci.0630-16.2016	https://doi.org/10.1523/jneurosci.0630-16.2016	PROPN
fnp-3806	3927	2	sierksma	sierksma	VERB
fnp-3806	3927	3	a	a	PRON
fnp-3806	3927	4	,	,	PUNCT
fnp-3806	3927	5	lu	lu	PROPN
fnp-3806	3927	6	a	a	PRON
fnp-3806	3927	7	,	,	PUNCT
fnp-3806	3927	8	salta	salta	PROPN
fnp-3806	3927	9	e	e	PROPN
fnp-3806	3927	10	,	,	PUNCT
fnp-3806	3927	11	et	et	PROPN
fnp-3806	3927	12	al	al	PROPN
fnp-3806	3927	13	.	.	PUNCT
fnp-3806	3928	1	deregulation	deregulation	NOUN
fnp-3806	3928	2	of	of	ADP
fnp-3806	3928	3	neuronal	neuronal	ADJ
fnp-3806	3928	4	mirnas	mirna	NOUN
fnp-3806	3928	5	induced	induce	VERB
fnp-3806	3928	6	by	by	ADP
fnp-3806	3928	7	amyloid	amyloid	NOUN
fnp-3806	3928	8	-	-	PUNCT
fnp-3806	3928	9	beta	beta	NOUN
fnp-3806	3928	10	or	or	CCONJ
fnp-3806	3928	11	tau	tau	PROPN
fnp-3806	3928	12	pathology	pathology	PROPN
fnp-3806	3928	13	.	.	PUNCT
fnp-3806	3929	1	mol	mol	ADP
fnp-3806	3929	2	neurodegener	neurodegener	PROPN
fnp-3806	3929	3	2018;13:54	2018;13:54	NUM
fnp-3806	3929	4	.	.	PUNCT
fnp-3806	3929	5	https://doi.org/10.1186/s13024-018-0285-1	https://doi.org/10.1186/s13024-018-0285-1	NUM
fnp-3806	3929	6	croce	croce	PROPN
fnp-3806	3929	7	n	n	CCONJ
fnp-3806	3929	8	,	,	PUNCT
fnp-3806	3929	9	gelfo	gelfo	NOUN
fnp-3806	3929	10	f	f	PROPN
fnp-3806	3929	11	,	,	PUNCT
fnp-3806	3929	12	ciotti	ciotti	PROPN
fnp-3806	3929	13	mt	mt	PROPN
fnp-3806	3929	14	,	,	PUNCT
fnp-3806	3929	15	et	et	PROPN
fnp-3806	3929	16	al	al	PROPN
fnp-3806	3929	17	.	.	PROPN
fnp-3806	3929	18	npy	npy	PROPN
fnp-3806	3929	19	modulates	modulate	VERB
fnp-3806	3929	20	mir-30a-5p	mir-30a-5p	PROPN
fnp-3806	3929	21	and	and	CCONJ
fnp-3806	3929	22	bdnf	bdnf	ADJ
fnp-3806	3929	23	in	in	ADP
fnp-3806	3929	24	opposite	opposite	ADJ
fnp-3806	3929	25	direction	direction	NOUN
fnp-3806	3929	26	in	in	ADP
fnp-3806	3929	27	an	an	DET
fnp-3806	3929	28	in	in	X
fnp-3806	3929	29	vitro	vitro	X
fnp-3806	3929	30	model	model	NOUN
fnp-3806	3929	31	of	of	ADP
fnp-3806	3929	32	alzheimer	alzheimer	PROPN
fnp-3806	3929	33	disease	disease	PROPN
fnp-3806	3929	34	:	:	PUNCT
fnp-3806	3929	35	a	a	DET
fnp-3806	3929	36	possible	possible	ADJ
fnp-3806	3929	37	role	role	NOUN
fnp-3806	3929	38	in	in	ADP
fnp-3806	3929	39	neuroprotection	neuroprotection	NOUN
fnp-3806	3929	40	?	?	PUNCT
fnp-3806	3930	1	mol	mol	ADP
fnp-3806	3930	2	cell	cell	NOUN
fnp-3806	3930	3	biochem	biochem	NOUN
fnp-3806	3930	4	2013;376	2013;376	NOUN
fnp-3806	3930	5	:	:	PUNCT
fnp-3806	3930	6	189	189	NUM
fnp-3806	3930	7	-	-	SYM
fnp-3806	3930	8	195	195	NUM
fnp-3806	3930	9	.	.	PUNCT
fnp-3806	3930	10	https://doi.org/10.1007/s11010-013-1567-0	https://doi.org/10.1007/s11010-013-1567-0	PUNCT
fnp-3806	3931	1	shaked	shake	VERB
fnp-3806	3931	2	i	i	PROPN
fnp-3806	3931	3	,	,	PUNCT
fnp-3806	3931	4	meerson	meerson	PROPN
fnp-3806	3931	5	a	a	PROPN
fnp-3806	3931	6	,	,	PUNCT
fnp-3806	3931	7	wolf	wolf	PROPN
fnp-3806	3931	8	y	y	PROPN
fnp-3806	3931	9	,	,	PUNCT
fnp-3806	3931	10	et	et	PROPN
fnp-3806	3931	11	al	al	PROPN
fnp-3806	3931	12	.	.	PROPN
fnp-3806	3931	13	microrna-132	microrna-132	PROPN
fnp-3806	3931	14	potentiates	potentiate	VERB
fnp-3806	3931	15	cholinergic	cholinergic	ADJ
fnp-3806	3931	16	anti	anti	ADJ
fnp-3806	3931	17	-	-	ADJ
fnp-3806	3931	18	inflammatory	inflammatory	ADJ
fnp-3806	3931	19	signaling	signaling	NOUN
fnp-3806	3931	20	by	by	ADP
fnp-3806	3931	21	targeting	target	VERB
fnp-3806	3931	22	acetylcholinesterase	acetylcholinesterase	NOUN
fnp-3806	3931	23	.	.	PUNCT
fnp-3806	3932	1	immunity	immunity	NOUN
fnp-3806	3932	2	2009;31	2009;31	NUM
fnp-3806	3932	3	:	:	PUNCT
fnp-3806	3932	4	965	965	NUM
fnp-3806	3932	5	-	-	SYM
fnp-3806	3932	6	973	973	NUM
fnp-3806	3932	7	.	.	PUNCT
fnp-3806	3933	1	https://doi.org/10.1016/j.immuni.2009.09.019	https://doi.org/10.1016/j.immuni.2009.09.019	PRON
fnp-3806	3933	2	shaltiel	shaltiel	VERB
fnp-3806	3933	3	g	g	PROPN
fnp-3806	3933	4	,	,	PUNCT
fnp-3806	3933	5	hanan	hanan	PROPN
fnp-3806	3933	6	m	m	PROPN
fnp-3806	3933	7	,	,	PUNCT
fnp-3806	3933	8	wolf	wolf	PROPN
fnp-3806	3933	9	y	y	PROPN
fnp-3806	3933	10	,	,	PUNCT
fnp-3806	3933	11	et	et	PROPN
fnp-3806	3933	12	al	al	PROPN
fnp-3806	3933	13	.	.	PROPN
fnp-3806	3933	14	hippocampal	hippocampal	PROPN
fnp-3806	3933	15	microrna-132	microrna-132	NOUN
fnp-3806	3933	16	mediates	mediate	VERB
fnp-3806	3933	17	stress	stress	NOUN
fnp-3806	3933	18	-	-	PUNCT
fnp-3806	3933	19	inducible	inducible	ADJ
fnp-3806	3933	20	cognitive	cognitive	ADJ
fnp-3806	3933	21	deficits	deficit	NOUN
fnp-3806	3933	22	through	through	ADP
fnp-3806	3933	23	its	its	PRON
fnp-3806	3933	24	acetylcholinesterase	acetylcholinesterase	NOUN
fnp-3806	3933	25	target	target	NOUN
fnp-3806	3933	26	.	.	PUNCT
fnp-3806	3934	1	brain	brain	NOUN
fnp-3806	3934	2	struct	struct	NOUN
fnp-3806	3934	3	funct	funct	PROPN
fnp-3806	3934	4	2013;218	2013;218	NOUN
fnp-3806	3934	5	:	:	PUNCT
fnp-3806	3934	6	59	59	NUM
fnp-3806	3934	7	-	-	SYM
fnp-3806	3934	8	72	72	NUM
fnp-3806	3934	9	.	.	PUNCT
fnp-3806	3935	1	https://doi.org/10.1007/s00429-011-0376-z	https://doi.org/10.1007/s00429-011-0376-z	NOUN
fnp-3806	3935	2	vo	vo	NOUN
fnp-3806	3935	3	n	n	PROPN
fnp-3806	3935	4	,	,	PUNCT
fnp-3806	3935	5	klein	klein	PROPN
fnp-3806	3935	6	me	i	PRON
fnp-3806	3935	7	,	,	PUNCT
fnp-3806	3935	8	varlamova	varlamova	PROPN
fnp-3806	3935	9	o	o	NOUN
fnp-3806	3935	10	,	,	PUNCT
fnp-3806	3935	11	et	et	PROPN
fnp-3806	3935	12	al	al	PROPN
fnp-3806	3935	13	.	.	PUNCT
fnp-3806	3936	1	a	a	DET
fnp-3806	3936	2	camp	camp	NOUN
fnp-3806	3936	3	-	-	PUNCT
fnp-3806	3936	4	response	response	NOUN
fnp-3806	3936	5	element	element	NOUN
fnp-3806	3936	6	binding	bind	VERB
fnp-3806	3936	7	protein	protein	NOUN
fnp-3806	3936	8	-	-	PUNCT
fnp-3806	3936	9	induced	induce	VERB
fnp-3806	3936	10	microrna	microrna	PROPN
fnp-3806	3936	11	regulates	regulate	VERB
fnp-3806	3936	12	neuronal	neuronal	ADJ
fnp-3806	3936	13	morphogenesis	morphogenesis	NOUN
fnp-3806	3936	14	.	.	PUNCT
fnp-3806	3937	1	proc	proc	PROPN
fnp-3806	3937	2	natl	natl	PROPN
fnp-3806	3937	3	acad	acad	PROPN
fnp-3806	3937	4	sci	sci	PROPN
fnp-3806	3937	5	usa	usa	PROPN
fnp-3806	3937	6	2005;102:16426	2005;102:16426	NUM
fnp-3806	3937	7	-	-	SYM
fnp-3806	3937	8	16431	16431	NUM
fnp-3806	3937	9	.	.	PUNCT
fnp-3806	3938	1	https://doi.org/10.1073/pnas.0508448102	https://doi.org/10.1073/pnas.0508448102	PROPN
fnp-3806	3938	2	llorens	llorens	PROPN
fnp-3806	3938	3	f	f	PROPN
fnp-3806	3938	4	,	,	PUNCT
fnp-3806	3938	5	thüne	thüne	PROPN
fnp-3806	3938	6	k	k	NOUN
fnp-3806	3938	7	,	,	PUNCT
fnp-3806	3938	8	andrés	andrés	PROPN
fnp-3806	3938	9	-	-	PUNCT
fnp-3806	3938	10	benito	benito	PROPN
fnp-3806	3938	11	p	p	PROPN
fnp-3806	3938	12	,	,	PUNCT
fnp-3806	3939	1	et	et	PROPN
fnp-3806	3939	2	al	al	PROPN
fnp-3806	3939	3	.	.	PUNCT
fnp-3806	3939	4	microrna	microrna	PROPN
fnp-3806	3939	5	expression	expression	NOUN
fnp-3806	3939	6	in	in	ADP
fnp-3806	3939	7	the	the	DET
fnp-3806	3939	8	locus	locus	NOUN
fnp-3806	3939	9	ceruleus	ceruleus	NOUN
fnp-3806	3939	10	,	,	PUNCT
fnp-3806	3939	11	entorhinal	entorhinal	ADJ
fnp-3806	3939	12	cortex	cortex	NOUN
fnp-3806	3939	13	,	,	PUNCT
fnp-3806	3939	14	and	and	CCONJ
fnp-3806	3939	15	hippocampus	hippocampus	NOUN
fnp-3806	3939	16	at	at	ADP
fnp-3806	3939	17	early	early	ADV
fnp-3806	3939	18	and	and	CCONJ
fnp-3806	3939	19	middle	middle	ADJ
fnp-3806	3939	20	stages	stage	NOUN
fnp-3806	3939	21	of	of	ADP
fnp-3806	3939	22	braak	braak	ADJ
fnp-3806	3939	23	neurofibrillary	neurofibrillary	PROPN
fnp-3806	3939	24	tangle	tangle	NOUN
fnp-3806	3939	25	pathology	pathology	NOUN
fnp-3806	3939	26	.	.	PUNCT
fnp-3806	3940	1	j	j	PROPN
fnp-3806	3940	2	mol	mol	PROPN
fnp-3806	3940	3	neurosci	neurosci	PROPN
fnp-3806	3940	4	2017;63:206	2017;63:206	PROPN
fnp-3806	3940	5	-	-	SYM
fnp-3806	3940	6	215	215	NUM
fnp-3806	3940	7	.	.	X
fnp-3806	3940	8	https://doi.org/10.1007/s12031-017-0971-4	https://doi.org/10.1007/s12031-017-0971-4	NUM
fnp-3806	3940	9	sun	sun	PROPN
fnp-3806	3940	10	c	c	PROPN
fnp-3806	3940	11	,	,	PUNCT
fnp-3806	3940	12	jia	jia	PROPN
fnp-3806	3940	13	n	n	PROPN
fnp-3806	3940	14	,	,	PUNCT
fnp-3806	3940	15	li	li	PROPN
fnp-3806	3940	16	r	r	PROPN
fnp-3806	3940	17	,	,	PUNCT
fnp-3806	3940	18	zhang	zhang	PROPN
fnp-3806	3940	19	z	z	PROPN
fnp-3806	3940	20	,	,	PUNCT
fnp-3806	3940	21	et	et	PROPN
fnp-3806	3940	22	al	al	PROPN
fnp-3806	3940	23	.	.	PROPN
fnp-3806	3940	24	mir-143	mir-143	PROPN
fnp-3806	3940	25	-	-	PUNCT
fnp-3806	3940	26	3p	3p	NUM
fnp-3806	3940	27	inhibition	inhibition	NOUN
fnp-3806	3940	28	promotes	promote	VERB
fnp-3806	3940	29	neuronal	neuronal	ADJ
fnp-3806	3940	30	survival	survival	NOUN
fnp-3806	3940	31	in	in	ADP
fnp-3806	3940	32	an	an	DET
fnp-3806	3940	33	alzheimer	alzheimer	NOUN
fnp-3806	3940	34	's	's	PART
fnp-3806	3940	35	disease	disease	NOUN
fnp-3806	3940	36	cell	cell	NOUN
fnp-3806	3940	37	model	model	NOUN
fnp-3806	3940	38	by	by	ADP
fnp-3806	3940	39	targeting	target	VERB
fnp-3806	3940	40	neuregulin-1	neuregulin-1	PROPN
fnp-3806	3940	41	.	.	PUNCT
fnp-3806	3941	1	folia	folia	PROPN
fnp-3806	3941	2	neuropathol	neuropathol	PROPN
fnp-3806	3941	3	2020;58:10	2020;58:10	PROPN
fnp-3806	3941	4	-	-	SYM
fnp-3806	3941	5	21	21	NUM
fnp-3806	3941	6	.	.	PUNCT
fnp-3806	3942	1	https://doi.org/10.5114/fn.2020.94002	https://doi.org/10.5114/fn.2020.94002	NOUN
fnp-3806	3942	2	hammad	hammad	PROPN
fnp-3806	3942	3	s	s	PROPN
fnp-3806	3942	4	,	,	PUNCT
fnp-3806	3942	5	mabondzo	mabondzo	VERB
fnp-3806	3942	6	a	a	PRON
fnp-3806	3942	7	,	,	PUNCT
fnp-3806	3942	8	hamoudi	hamoudi	ADJ
fnp-3806	3942	9	r	r	NOUN
fnp-3806	3942	10	,	,	PUNCT
fnp-3806	3942	11	et	et	PROPN
fnp-3806	3942	12	al	al	PROPN
fnp-3806	3942	13	.	.	PUNCT
fnp-3806	3943	1	regulation	regulation	NOUN
fnp-3806	3943	2	of	of	ADP
fnp-3806	3943	3	p	p	NOUN
fnp-3806	3943	4	-	-	PUNCT
fnp-3806	3943	5	glycoprotein	glycoprotein	NOUN
fnp-3806	3943	6	by	by	ADP
fnp-3806	3943	7	mir-27a-3p	mir-27a-3p	PROPN
fnp-3806	3943	8	at	at	ADP
fnp-3806	3943	9	the	the	DET
fnp-3806	3943	10	brain	brain	NOUN
fnp-3806	3943	11	endothelial	endothelial	ADJ
fnp-3806	3943	12	barrier	barrier	NOUN
fnp-3806	3943	13	.	.	PUNCT
fnp-3806	3944	1	j	j	PROPN
fnp-3806	3944	2	pharm	pharm	PROPN
fnp-3806	3944	3	sci	sci	PROPN
fnp-3806	3944	4	2022;111:1470	2022;111:1470	NUM
fnp-3806	3944	5	-	-	SYM
fnp-3806	3944	6	1479	1479	NUM
fnp-3806	3944	7	.	.	PUNCT
fnp-3806	3945	1	https://doi.org/10.1016/j.xphs.2021.10.021	https://doi.org/10.1016/j.xphs.2021.10.021	NUM
fnp-3806	3945	2	harati	harati	PROPN
fnp-3806	3945	3	r	r	NOUN
fnp-3806	3945	4	,	,	PUNCT
fnp-3806	3945	5	hammad	hammad	PROPN
fnp-3806	3945	6	s	s	PROPN
fnp-3806	3945	7	,	,	PUNCT
fnp-3806	3945	8	tlili	tlili	NOUN
fnp-3806	3945	9	a	a	NOUN
fnp-3806	3945	10	,	,	PUNCT
fnp-3806	3945	11	et	et	PROPN
fnp-3806	3945	12	al	al	PROPN
fnp-3806	3945	13	.	.	PUNCT
fnp-3806	3946	1	mir-27a-3p	mir-27a-3p	PROPN
fnp-3806	3946	2	regulates	regulate	VERB
fnp-3806	3946	3	expression	expression	NOUN
fnp-3806	3946	4	of	of	ADP
fnp-3806	3946	5	intercellular	intercellular	ADJ
fnp-3806	3946	6	junctions	junction	NOUN
fnp-3806	3946	7	at	at	ADP
fnp-3806	3946	8	the	the	DET
fnp-3806	3946	9	brain	brain	NOUN
fnp-3806	3946	10	endothelium	endothelium	NOUN
fnp-3806	3946	11	and	and	CCONJ
fnp-3806	3946	12	controls	control	VERB
fnp-3806	3946	13	the	the	DET
fnp-3806	3946	14	endothelial	endothelial	ADJ
fnp-3806	3946	15	barrier	barrier	NOUN
fnp-3806	3946	16	permeability	permeability	NOUN
fnp-3806	3946	17	.	.	PUNCT
fnp-3806	3947	1	plos	plos	PROPN
fnp-3806	3947	2	one	one	NUM
fnp-3806	3947	3	2022;17	2022;17	NUM
fnp-3806	3947	4	:	:	PUNCT
fnp-3806	3947	5	e0262152	e0262152	PROPN
fnp-3806	3947	6	.	.	PUNCT
fnp-3806	3948	1	https://doi.org/10.1371/journal.pone.0262152	https://doi.org/10.1371/journal.pone.0262152	PROPN
fnp-3806	3948	2	sochocka	sochocka	PROPN
fnp-3806	3948	3	m	m	PROPN
fnp-3806	3948	4	,	,	PUNCT
fnp-3806	3948	5	zwolińska	zwolińska	PROPN
fnp-3806	3948	6	k	k	PROPN
fnp-3806	3948	7	,	,	PUNCT
fnp-3806	3948	8	leszek	leszek	PROPN
fnp-3806	3948	9	j.	j.	PROPN
fnp-3806	3948	10	the	the	DET
fnp-3806	3948	11	infectious	infectious	ADJ
fnp-3806	3948	12	etiology	etiology	NOUN
fnp-3806	3948	13	of	of	ADP
fnp-3806	3948	14	alzheimer	alzheimer	PROPN
fnp-3806	3948	15	's	's	PART
fnp-3806	3948	16	disease	disease	NOUN
fnp-3806	3948	17	.	.	PUNCT
fnp-3806	3949	1	curr	curr	PROPN
fnp-3806	3949	2	neuropharmacol	neuropharmacol	PROPN
fnp-3806	3949	3	.	.	PUNCT
fnp-3806	3950	1	2017;15:996	2017;15:996	NOUN
fnp-3806	3950	2	-	-	PUNCT
fnp-3806	3950	3	1009	1009	NUM
fnp-3806	3950	4	.	.	PUNCT
fnp-3806	3951	1	https://doi.org/10.2174/1570159x15666170313122937	https://doi.org/10.2174/1570159x15666170313122937	X
fnp-3806	3951	2	vigasova	vigasova	PROPN
fnp-3806	3952	1	d	d	PROPN
fnp-3806	3952	2	,	,	PUNCT
fnp-3806	3952	3	nemergut	nemergut	PROPN
fnp-3806	3952	4	m	m	PROPN
fnp-3806	3952	5	,	,	PUNCT
fnp-3806	3952	6	liskova	liskova	PROPN
fnp-3806	3952	7	b	b	AUX
fnp-3806	3952	8	,	,	PUNCT
fnp-3806	3952	9	et	et	PROPN
fnp-3806	3952	10	al	al	PROPN
fnp-3806	3952	11	.	.	PUNCT
fnp-3806	3952	12	multi	multi	ADJ
fnp-3806	3952	13	-	-	ADJ
fnp-3806	3952	14	pathogen	pathogen	NOUN
fnp-3806	3952	15	infections	infection	NOUN
fnp-3806	3952	16	and	and	CCONJ
fnp-3806	3952	17	alzheimer	alzheimer	PROPN
fnp-3806	3952	18	's	's	PART
fnp-3806	3952	19	disease	disease	NOUN
fnp-3806	3952	20	.	.	PUNCT
fnp-3806	3953	1	microb	microb	PROPN
fnp-3806	3953	2	cell	cell	PROPN
fnp-3806	3953	3	fact	fact	NOUN
fnp-3806	3953	4	2021;20:25	2021;20:25	NUM
fnp-3806	3953	5	.	.	PUNCT
fnp-3806	3954	1	https://doi.org/10.1186/s12934-021-01520-7	https://doi.org/10.1186/s12934-021-01520-7	NUM
fnp-3806	3954	2	licastro	licastro	PROPN
fnp-3806	3954	3	f	f	NOUN
fnp-3806	3954	4	,	,	PUNCT
fnp-3806	3954	5	carbone	carbone	PROPN
fnp-3806	3954	6	i	i	PRON
fnp-3806	3954	7	,	,	PUNCT
fnp-3806	3954	8	raschi	raschi	PROPN
fnp-3806	3954	9	e	e	PROPN
fnp-3806	3954	10	,	,	PUNCT
fnp-3806	3954	11	et	et	PROPN
fnp-3806	3954	12	al	al	PROPN
fnp-3806	3954	13	.	.	PUNCT
fnp-3806	3955	1	the	the	DET
fnp-3806	3955	2	21st	21st	ADJ
fnp-3806	3955	3	century	century	NOUN
fnp-3806	3955	4	epidemic	epidemic	NOUN
fnp-3806	3955	5	:	:	PUNCT
fnp-3806	3955	6	infections	infection	NOUN
fnp-3806	3955	7	as	as	ADP
fnp-3806	3955	8	inductors	inductor	NOUN
fnp-3806	3955	9	of	of	ADP
fnp-3806	3955	10	neurodegeneration	neurodegeneration	NOUN
fnp-3806	3955	11	associated	associate	VERB
fnp-3806	3955	12	with	with	ADP
fnp-3806	3955	13	alzheimer	alzheimer	PROPN
fnp-3806	3955	14	’s	’s	PART
fnp-3806	3955	15	disease	disease	NOUN
fnp-3806	3955	16	.	.	PUNCT
fnp-3806	3956	1	immun	immun	PROPN
fnp-3806	3956	2	ageing	age	VERB
fnp-3806	3956	3	2014;11:22	2014;11:22	PROPN
fnp-3806	3956	4	.	.	PUNCT
fnp-3806	3957	1	https://doi.org/10.1186/1742-4933-11-8	https://doi.org/10.1186/1742-4933-11-8	PROPN
fnp-3806	3957	2	maheshwari	maheshwari	PROPN
fnp-3806	3957	3	p	p	PROPN
fnp-3806	3957	4	,	,	PUNCT
fnp-3806	3957	5	eslick	eslick	NOUN
fnp-3806	3957	6	gd	gd	PROPN
fnp-3806	3957	7	.	.	PUNCT
fnp-3806	3958	1	bacterial	bacterial	ADJ
fnp-3806	3958	2	infection	infection	NOUN
fnp-3806	3958	3	and	and	CCONJ
fnp-3806	3958	4	alzheimer	alzheimer	PROPN
fnp-3806	3958	5	’s	’s	PART
fnp-3806	3958	6	disease	disease	NOUN
fnp-3806	3958	7	:	:	PUNCT
fnp-3806	3958	8	a	a	DET
fnp-3806	3958	9	meta	meta	ADJ
fnp-3806	3958	10	-	-	PUNCT
fnp-3806	3958	11	analysis	analysis	NOUN
fnp-3806	3958	12	.	.	PUNCT
fnp-3806	3959	1	j	j	PROPN
fnp-3806	3959	2	alzheimers	alzheimers	PROPN
fnp-3806	3959	3	dis	dis	PROPN
fnp-3806	3959	4	2015;43:957	2015;43:957	PROPN
fnp-3806	3959	5	-	-	SYM
fnp-3806	3959	6	966	966	NUM
fnp-3806	3959	7	.	.	PUNCT
fnp-3806	3960	1	https://doi.org/10.3233/jad-140621	https://doi.org/10.3233/jad-140621	PROPN
fnp-3806	3960	2	ashraf	ashraf	VERB
fnp-3806	3960	3	gm	gm	PROPN
fnp-3806	3960	4	,	,	PUNCT
fnp-3806	3960	5	tarasov	tarasov	NOUN
fnp-3806	3960	6	vv	vv	NOUN
fnp-3806	3960	7	,	,	PUNCT
fnp-3806	3960	8	makhmutovа	makhmutovа	NOUN
fnp-3806	3960	9	a	a	PROPN
fnp-3806	3960	10	,	,	PUNCT
fnp-3806	3960	11	et	et	PROPN
fnp-3806	3960	12	al	al	PROPN
fnp-3806	3960	13	.	.	PUNCT
fnp-3806	3961	1	the	the	DET
fnp-3806	3961	2	possibility	possibility	NOUN
fnp-3806	3961	3	of	of	ADP
fnp-3806	3961	4	an	an	DET
fnp-3806	3961	5	infectious	infectious	ADJ
fnp-3806	3961	6	etiology	etiology	NOUN
fnp-3806	3961	7	of	of	ADP
fnp-3806	3961	8	alzheimer	alzheimer	PROPN
fnp-3806	3961	9	disease	disease	PROPN
fnp-3806	3961	10	.	.	PUNCT
fnp-3806	3962	1	mol	mol	ADP
fnp-3806	3962	2	neurobiol	neurobiol	PROPN
fnp-3806	3962	3	2019;56:4479	2019;56:4479	PROPN
fnp-3806	3962	4	-	-	SYM
fnp-3806	3962	5	4491	4491	NUM
fnp-3806	3962	6	.	.	PUNCT
fnp-3806	3963	1	https://doi.org/10.1007/s12035-018-1388-y	https://doi.org/10.1007/s12035-018-1388-y	PROPN
fnp-3806	3963	2	macdonald	macdonald	PROPN
fnp-3806	3963	3	ab	ab	PROPN
fnp-3806	3963	4	,	,	PUNCT
fnp-3806	3963	5	miranda	miranda	PROPN
fnp-3806	3963	6	jm	jm	PROPN
fnp-3806	3963	7	.	.	PROPN
fnp-3806	3963	8	concurrent	concurrent	ADJ
fnp-3806	3963	9	neocortical	neocortical	ADJ
fnp-3806	3963	10	borreliosis	borreliosis	NOUN
fnp-3806	3963	11	and	and	CCONJ
fnp-3806	3963	12	alzheimer	alzheimer	PROPN
fnp-3806	3963	13	’s	’s	PART
fnp-3806	3963	14	disease	disease	NOUN
fnp-3806	3963	15	.	.	PUNCT
fnp-3806	3964	1	hum	hum	PROPN
fnp-3806	3964	2	pathol	pathol	NOUN
fnp-3806	3964	3	1987;18:759	1987;18:759	NUM
fnp-3806	3964	4	-	-	SYM
fnp-3806	3964	5	761	761	NUM
fnp-3806	3964	6	.	.	PUNCT
fnp-3806	3965	1	https://doi.org/10.1016/s0046-8177(87)80252-6	https://doi.org/10.1016/s0046-8177(87)80252-6	PROPN
fnp-3806	3965	2	marques	marques	PROPN
fnp-3806	3965	3	ar	ar	PROPN
fnp-3806	3965	4	,	,	PUNCT
fnp-3806	3965	5	weir	weir	PROPN
fnp-3806	3965	6	sc	sc	PROPN
fnp-3806	3965	7	,	,	PUNCT
fnp-3806	3965	8	fahle	fahle	PROPN
fnp-3806	3965	9	ga	ga	PROPN
fnp-3806	3965	10	,	,	PUNCT
fnp-3806	3965	11	et	et	PROPN
fnp-3806	3965	12	al	al	PROPN
fnp-3806	3965	13	.	.	PROPN
fnp-3806	3965	14	lack	lack	NOUN
fnp-3806	3965	15	of	of	ADP
fnp-3806	3965	16	evidence	evidence	NOUN
fnp-3806	3965	17	of	of	ADP
fnp-3806	3965	18	borrelia	borrelia	NOUN
fnp-3806	3965	19	involvement	involvement	NOUN
fnp-3806	3965	20	in	in	ADP
fnp-3806	3965	21	alzheimer	alzheimer	PROPN
fnp-3806	3965	22	's	's	PART
fnp-3806	3965	23	disease	disease	NOUN
fnp-3806	3965	24	.	.	PUNCT
fnp-3806	3966	1	j	j	PROPN
fnp-3806	3966	2	infect	infect	VERB
fnp-3806	3966	3	dis	dis	PROPN
fnp-3806	3966	4	2000;182:1006	2000;182:1006	NUM
fnp-3806	3966	5	-	-	SYM
fnp-3806	3966	6	1007	1007	NUM
fnp-3806	3966	7	.	.	PUNCT
fnp-3806	3967	1	https://doi.org/10.1086/315792	https://doi.org/10.1086/315792	NOUN
fnp-3806	3967	2	riviere	riviere	PROPN
fnp-3806	3967	3	gr	gr	PROPN
fnp-3806	3967	4	,	,	PUNCT
fnp-3806	3967	5	riviere	riviere	PROPN
fnp-3806	3967	6	kh	kh	PROPN
fnp-3806	3967	7	,	,	PUNCT
fnp-3806	3967	8	smith	smith	PROPN
fnp-3806	3967	9	ks	ks	PROPN
fnp-3806	3967	10	.	.	PROPN
fnp-3806	3967	11	molecular	molecular	ADJ
fnp-3806	3967	12	and	and	CCONJ
fnp-3806	3967	13	immunological	immunological	ADJ
fnp-3806	3967	14	evidence	evidence	NOUN
fnp-3806	3967	15	of	of	ADP
fnp-3806	3967	16	oral	oral	ADJ
fnp-3806	3967	17	treponema	treponema	NOUN
fnp-3806	3967	18	in	in	ADP
fnp-3806	3967	19	the	the	DET
fnp-3806	3967	20	human	human	ADJ
fnp-3806	3967	21	brain	brain	NOUN
fnp-3806	3967	22	and	and	CCONJ
fnp-3806	3967	23	their	their	PRON
fnp-3806	3967	24	association	association	NOUN
fnp-3806	3967	25	with	with	ADP
fnp-3806	3967	26	alzheimer	alzheimer	PROPN
fnp-3806	3967	27	’s	’s	PART
fnp-3806	3967	28	disease	disease	NOUN
fnp-3806	3967	29	.	.	PUNCT
fnp-3806	3968	1	oral	oral	ADJ
fnp-3806	3968	2	microbiol	microbiol	PROPN
fnp-3806	3968	3	immunol	immunol	NOUN
fnp-3806	3968	4	.	.	PUNCT
fnp-3806	3969	1	2002;17:113	2002;17:113	PROPN
fnp-3806	3969	2	-	-	SYM
fnp-3806	3969	3	118	118	NUM
fnp-3806	3969	4	.	.	PUNCT
fnp-3806	3970	1	https://doi.org/10.1046/j.0902-0055.2001.00100.x	https://doi.org/10.1046/j.0902-0055.2001.00100.x	ADJ
fnp-3806	3970	2	miklossy	miklossy	PROPN
fnp-3806	3970	3	j.	j.	PROPN
fnp-3806	3970	4	alzheimer	alzheimer	PROPN
fnp-3806	3970	5	’s	’s	PART
fnp-3806	3970	6	disease	disease	NOUN
fnp-3806	3970	7	:	:	PUNCT
fnp-3806	3970	8	a	a	DET
fnp-3806	3970	9	neurospirochetosis	neurospirochetosis	NOUN
fnp-3806	3970	10	.	.	PUNCT
fnp-3806	3971	1	analysis	analysis	NOUN
fnp-3806	3971	2	of	of	ADP
fnp-3806	3971	3	the	the	DET
fnp-3806	3971	4	evidence	evidence	NOUN
fnp-3806	3971	5	following	follow	VERB
fnp-3806	3971	6	koch	koch	PROPN
fnp-3806	3971	7	’s	’s	PART
fnp-3806	3971	8	and	and	CCONJ
fnp-3806	3971	9	hill	hill	PROPN
fnp-3806	3971	10	’s	’s	PART
fnp-3806	3971	11	criteria	criterion	NOUN
fnp-3806	3971	12	.	.	PUNCT
fnp-3806	3972	1	j	j	PROPN
fnp-3806	3972	2	neuroinfammation	neuroinfammation	PROPN
fnp-3806	3972	3	2011;8:90	2011;8:90	NOUN
fnp-3806	3972	4	.	.	PUNCT
fnp-3806	3973	1	https://doi.org/10.1186/1742-2094-8-90	https://doi.org/10.1186/1742-2094-8-90	X
fnp-3806	3973	2	miklossy	miklossy	ADJ
fnp-3806	3973	3	j.	j.	PROPN
fnp-3806	3973	4	historic	historic	ADJ
fnp-3806	3973	5	evidence	evidence	NOUN
fnp-3806	3973	6	to	to	PART
fnp-3806	3973	7	support	support	VERB
fnp-3806	3973	8	a	a	DET
fnp-3806	3973	9	causal	causal	ADJ
fnp-3806	3973	10	relationship	relationship	NOUN
fnp-3806	3973	11	between	between	ADP
fnp-3806	3973	12	spirochetal	spirochetal	ADJ
fnp-3806	3973	13	infections	infection	NOUN
fnp-3806	3973	14	and	and	CCONJ
fnp-3806	3973	15	alzheimer	alzheimer	PROPN
fnp-3806	3973	16	’s	’s	PART
fnp-3806	3973	17	disease	disease	NOUN
fnp-3806	3973	18	.	.	PUNCT
fnp-3806	3974	1	front	front	ADJ
fnp-3806	3974	2	aging	age	VERB
fnp-3806	3974	3	neurosci	neurosci	NOUN
fnp-3806	3974	4	2015;7:46	2015;7:46	VERB
fnp-3806	3974	5	.	.	PUNCT
fnp-3806	3975	1	https://doi.org/10.3389/fnagi.2015.00046	https://doi.org/10.3389/fnagi.2015.00046	PROPN
fnp-3806	3975	2	senejania	senejania	PROPN
fnp-3806	3975	3	ag	ag	PROPN
fnp-3806	3975	4	,	,	PUNCT
fnp-3806	3975	5	maghsoudloua	maghsoudloua	PROPN
fnp-3806	3975	6	j	j	PROPN
fnp-3806	3975	7	,	,	PUNCT
fnp-3806	3975	8	el	el	PROPN
fnp-3806	3975	9	-	-	PROPN
fnp-3806	3975	10	zohirya	zohirya	PROPN
fnp-3806	3975	11	d	d	PROPN
fnp-3806	3975	12	,	,	PUNCT
fnp-3806	3975	13	et	et	PROPN
fnp-3806	3975	14	al	al	PROPN
fnp-3806	3975	15	.	.	PROPN
fnp-3806	3975	16	borrelia	borrelia	PROPN
fnp-3806	3975	17	burgdorferi	burgdorferi	ADJ
fnp-3806	3975	18	co	co	VERB
fnp-3806	3975	19	-	-	NOUN
fnp-3806	3975	20	localizing	localize	VERB
fnp-3806	3975	21	with	with	ADP
fnp-3806	3975	22	amyloid	amyloid	NOUN
fnp-3806	3975	23	markers	marker	NOUN
fnp-3806	3975	24	in	in	ADP
fnp-3806	3975	25	alzheimer	alzheimer	PROPN
fnp-3806	3975	26	’s	’s	PART
fnp-3806	3975	27	disease	disease	NOUN
fnp-3806	3975	28	brain	brain	NOUN
fnp-3806	3975	29	tissues	tissue	NOUN
fnp-3806	3975	30	.	.	PUNCT
fnp-3806	3976	1	j	j	PROPN
fnp-3806	3976	2	alzheimers	alzheimers	PROPN
fnp-3806	3976	3	dis	dis	PROPN
fnp-3806	3976	4	2022;85	2022;85	NUM
fnp-3806	3976	5	:	:	PUNCT
fnp-3806	3976	6	889	889	NUM
fnp-3806	3976	7	-	-	SYM
fnp-3806	3976	8	903	903	NUM
fnp-3806	3976	9	.	.	PUNCT
fnp-3806	3977	1	https://doi.org/10.3233/jad-215398	https://doi.org/10.3233/jad-215398	PROPN
fnp-3806	3977	2	emery	emery	PROPN
fnp-3806	3977	3	dc	dc	PROPN
fnp-3806	3977	4	,	,	PUNCT
fnp-3806	3977	5	shoemark	shoemark	VERB
fnp-3806	3977	6	dk	dk	PROPN
fnp-3806	3977	7	,	,	PUNCT
fnp-3806	3977	8	batstone	batstone	PROPN
fnp-3806	3977	9	te	te	PROPN
fnp-3806	3977	10	,	,	PUNCT
fnp-3806	3977	11	et	et	PROPN
fnp-3806	3977	12	al	al	PROPN
fnp-3806	3977	13	.	.	PUNCT
fnp-3806	3978	1	16s	16s	PROPN
fnp-3806	3978	2	rrna	rrna	VERB
fnp-3806	3978	3	next	next	ADJ
fnp-3806	3978	4	generation	generation	NOUN
fnp-3806	3978	5	sequencing	sequence	VERB
fnp-3806	3978	6	analysis	analysis	NOUN
fnp-3806	3978	7	shows	show	VERB
fnp-3806	3978	8	bacteria	bacteria	NOUN
fnp-3806	3978	9	in	in	ADP
fnp-3806	3978	10	alzheimer	alzheimer	PROPN
fnp-3806	3978	11	’s	’s	PART
fnp-3806	3978	12	post	post	ADJ
fnp-3806	3978	13	-	-	ADJ
fnp-3806	3978	14	mortem	mortem	ADJ
fnp-3806	3978	15	brain	brain	NOUN
fnp-3806	3978	16	.	.	PUNCT
fnp-3806	3979	1	front	front	ADJ
fnp-3806	3979	2	aging	age	VERB
fnp-3806	3979	3	neurosci	neurosci	NOUN
fnp-3806	3979	4	.	.	PUNCT
fnp-3806	3979	5	2017;9:195	2017;9:195	NOUN
fnp-3806	3979	6	.	.	PUNCT
fnp-3806	3980	1	https://doi.org/10.3389/fnagi.2017.00195	https://doi.org/10.3389/fnagi.2017.00195	PROPN
fnp-3806	3980	2	soscia	soscia	PROPN
fnp-3806	3980	3	sj	sj	VERB
fnp-3806	3980	4	,	,	PUNCT
fnp-3806	3980	5	kirby	kirby	PROPN
fnp-3806	3980	6	je	je	PROPN
fnp-3806	3980	7	,	,	PUNCT
fnp-3806	3980	8	washicosky	washicosky	PROPN
fnp-3806	3980	9	kj	kj	PROPN
fnp-3806	3980	10	,	,	PUNCT
fnp-3806	3980	11	et	et	PROPN
fnp-3806	3980	12	al	al	PROPN
fnp-3806	3980	13	.	.	PUNCT
fnp-3806	3981	1	the	the	DET
fnp-3806	3981	2	alzheimer	alzheimer	PROPN
fnp-3806	3981	3	’s	’s	PART
fnp-3806	3981	4	disease	disease	NOUN
fnp-3806	3981	5	-	-	PUNCT
fnp-3806	3981	6	associated	associate	VERB
fnp-3806	3981	7	amyloid	amyloid	NOUN
fnp-3806	3981	8	beta	beta	NOUN
fnp-3806	3981	9	-	-	PUNCT
fnp-3806	3981	10	protein	protein	NOUN
fnp-3806	3981	11	is	be	AUX
fnp-3806	3981	12	an	an	DET
fnp-3806	3981	13	antimicrobial	antimicrobial	ADJ
fnp-3806	3981	14	peptide	peptide	NOUN
fnp-3806	3981	15	.	.	PUNCT
fnp-3806	3982	1	plos	plos	PROPN
fnp-3806	3982	2	one	one	NUM
fnp-3806	3982	3	2010;5	2010;5	NUM
fnp-3806	3982	4	:	:	PUNCT
fnp-3806	3982	5	e9505	e9505	ADJ
fnp-3806	3982	6	.	.	PUNCT
fnp-3806	3983	1	https://doi.org/10.1371/journal.pone.0009505	https://doi.org/10.1371/journal.pone.0009505	PROPN
fnp-3806	3983	2	kamer	kamer	PROPN
fnp-3806	3983	3	ar	ar	PROPN
fnp-3806	3983	4	,	,	PUNCT
fnp-3806	3983	5	dasanayake	dasanayake	VERB
fnp-3806	3983	6	ap	ap	PROPN
fnp-3806	3983	7	,	,	PUNCT
fnp-3806	3983	8	craig	craig	PROPN
fnp-3806	3983	9	rg	rg	PROPN
fnp-3806	3983	10	,	,	PUNCT
fnp-3806	3983	11	et	et	PROPN
fnp-3806	3983	12	al	al	PROPN
fnp-3806	3983	13	.	.	PROPN
fnp-3806	3983	14	alzheimer	alzheimer	PROPN
fnp-3806	3983	15	’s	’s	PART
fnp-3806	3983	16	disease	disease	NOUN
fnp-3806	3983	17	and	and	CCONJ
fnp-3806	3983	18	peripheral	peripheral	ADJ
fnp-3806	3983	19	infections	infection	NOUN
fnp-3806	3983	20	:	:	PUNCT
fnp-3806	3983	21	the	the	DET
fnp-3806	3983	22	possible	possible	ADJ
fnp-3806	3983	23	contribution	contribution	NOUN
fnp-3806	3983	24	from	from	ADP
fnp-3806	3983	25	periodontal	periodontal	ADJ
fnp-3806	3983	26	infections	infection	NOUN
fnp-3806	3983	27	,	,	PUNCT
fnp-3806	3983	28	model	model	NOUN
fnp-3806	3983	29	and	and	CCONJ
fnp-3806	3983	30	hypothesis	hypothesis	NOUN
fnp-3806	3983	31	.	.	PUNCT
fnp-3806	3984	1	j	j	PROPN
fnp-3806	3984	2	alzheimers	alzheimers	PROPN
fnp-3806	3984	3	dis	dis	PROPN
fnp-3806	3984	4	2008;13:437	2008;13:437	NUM
fnp-3806	3984	5	-	-	SYM
fnp-3806	3984	6	449	449	NUM
fnp-3806	3984	7	.	.	PUNCT
fnp-3806	3984	8	https://doi.org/10.3233/jad-2008-13408	https://doi.org/10.3233/jad-2008-13408	PROPN
fnp-3806	3984	9	sparks	spark	VERB
fnp-3806	3984	10	stein	stein	PROPN
fnp-3806	3984	11	p	p	PROPN
fnp-3806	3984	12	,	,	PUNCT
fnp-3806	3984	13	stefen	stefen	PROPN
fnp-3806	3984	14	mj	mj	PROPN
fnp-3806	3984	15	,	,	PUNCT
fnp-3806	3984	16	smith	smith	PROPN
fnp-3806	3984	17	c	c	PROPN
fnp-3806	3984	18	,	,	PUNCT
fnp-3806	3984	19	et	et	PROPN
fnp-3806	3984	20	al	al	PROPN
fnp-3806	3984	21	.	.	PROPN
fnp-3806	3984	22	serum	serum	PROPN
fnp-3806	3984	23	antibodies	antibody	NOUN
fnp-3806	3984	24	to	to	ADP
fnp-3806	3984	25	periodontal	periodontal	ADJ
fnp-3806	3984	26	pathogens	pathogen	NOUN
fnp-3806	3984	27	are	be	AUX
fnp-3806	3984	28	a	a	DET
fnp-3806	3984	29	risk	risk	NOUN
fnp-3806	3984	30	factor	factor	NOUN
fnp-3806	3984	31	for	for	ADP
fnp-3806	3984	32	alzheimer	alzheimer	PROPN
fnp-3806	3984	33	’s	’s	PART
fnp-3806	3984	34	disease	disease	NOUN
fnp-3806	3984	35	.	.	PUNCT
fnp-3806	3985	1	alzheimer	alzheimer	PROPN
fnp-3806	3985	2	’s	’s	PART
fnp-3806	3985	3	dement	dement	PROPN
fnp-3806	3985	4	2012;8:196	2012;8:196	NUM
fnp-3806	3985	5	-	-	SYM
fnp-3806	3985	6	203	203	NUM
fnp-3806	3985	7	.	.	PUNCT
fnp-3806	3986	1	https://doi.org/10.1016/j.jalz.2011.04.006	https://doi.org/10.1016/j.jalz.2011.04.006	PROPN
fnp-3806	3986	2	beydoun	beydoun	PROPN
fnp-3806	3986	3	ma	ma	PROPN
fnp-3806	3986	4	,	,	PUNCT
fnp-3806	3986	5	beydoun	beydoun	PROPN
fnp-3806	3986	6	ha	ha	INTJ
fnp-3806	3986	7	,	,	PUNCT
fnp-3806	3986	8	weiss	weiss	PROPN
fnp-3806	3986	9	j	j	PROPN
fnp-3806	3986	10	,	,	PUNCT
fnp-3806	3986	11	et	et	PROPN
fnp-3806	3986	12	al	al	PROPN
fnp-3806	3986	13	.	.	PUNCT
fnp-3806	3987	1	helicobacter	helicobacter	NOUN
fnp-3806	3987	2	pylori	pylori	NOUN
fnp-3806	3987	3	,	,	PUNCT
fnp-3806	3987	4	periodontal	periodontal	ADJ
fnp-3806	3987	5	pathogens	pathogen	NOUN
fnp-3806	3987	6	,	,	PUNCT
fnp-3806	3987	7	and	and	CCONJ
fnp-3806	3987	8	their	their	PRON
fnp-3806	3987	9	interactive	interactive	ADJ
fnp-3806	3987	10	association	association	NOUN
fnp-3806	3987	11	with	with	ADP
fnp-3806	3987	12	incident	incident	NOUN
fnp-3806	3987	13	all	all	DET
fnp-3806	3987	14	-	-	PUNCT
fnp-3806	3987	15	cause	cause	NOUN
fnp-3806	3987	16	and	and	CCONJ
fnp-3806	3987	17	alzheimer	alzheimer	PROPN
fnp-3806	3987	18	’s	’s	PART
fnp-3806	3987	19	disease	disease	NOUN
fnp-3806	3987	20	dementia	dementia	NOUN
fnp-3806	3987	21	in	in	ADP
fnp-3806	3987	22	a	a	DET
fnp-3806	3987	23	large	large	ADJ
fnp-3806	3987	24	national	national	ADJ
fnp-3806	3987	25	survey	survey	NOUN
fnp-3806	3987	26	.	.	PUNCT
fnp-3806	3988	1	mol	mol	ADP
fnp-3806	3988	2	psychiatry	psychiatry	PROPN
fnp-3806	3988	3	2021;26:6038	2021;26:6038	PROPN
fnp-3806	3988	4	-	-	PUNCT
fnp-3806	3988	5	6053	6053	NUM
fnp-3806	3988	6	.	.	PUNCT
fnp-3806	3989	1	https://doi.org/10.1038/s41380-020-0736-2	https://doi.org/10.1038/s41380-020-0736-2	PROPN
fnp-3806	3989	2	kamer	kamer	PROPN
fnp-3806	3989	3	ar	ar	PROPN
fnp-3806	3989	4	,	,	PUNCT
fnp-3806	3989	5	craig	craig	PROPN
fnp-3806	3989	6	rg	rg	PROPN
fnp-3806	3989	7	,	,	PUNCT
fnp-3806	3989	8	pirraglia	pirraglia	PROPN
fnp-3806	3989	9	e	e	PROPN
fnp-3806	3989	10	,	,	PUNCT
fnp-3806	3989	11	et	et	PROPN
fnp-3806	3989	12	al	al	PROPN
fnp-3806	3989	13	.	.	PUNCT
fnp-3806	3990	1	tnf	tnf	PROPN
fnp-3806	3990	2	-	-	PUNCT
fnp-3806	3990	3	α	α	PROPN
fnp-3806	3990	4	and	and	CCONJ
fnp-3806	3990	5	antibodies	antibodie	VERB
fnp-3806	3990	6	to	to	ADP
fnp-3806	3990	7	periodontal	periodontal	ADJ
fnp-3806	3990	8	bacteria	bacteria	NOUN
fnp-3806	3990	9	discriminate	discriminate	VERB
fnp-3806	3990	10	between	between	ADP
fnp-3806	3990	11	alzheimer	alzheimer	PROPN
fnp-3806	3990	12	’s	’s	PART
fnp-3806	3990	13	disease	disease	NOUN
fnp-3806	3990	14	patients	patient	NOUN
fnp-3806	3990	15	and	and	CCONJ
fnp-3806	3990	16	normal	normal	ADJ
fnp-3806	3990	17	subjects	subject	NOUN
fnp-3806	3990	18	.	.	PUNCT
fnp-3806	3991	1	j	j	PROPN
fnp-3806	3991	2	neuroimmunol	neuroimmunol	PROPN
fnp-3806	3991	3	.	.	PUNCT
fnp-3806	3992	1	2009;216:92	2009;216:92	NUM
fnp-3806	3992	2	-	-	SYM
fnp-3806	3992	3	97	97	NUM
fnp-3806	3992	4	.	.	PUNCT
fnp-3806	3993	1	https://doi.org/10.1016/j.jneuroim.2009.08.013	https://doi.org/10.1016/j.jneuroim.2009.08.013	NUM
fnp-3806	3993	2	abbayya	abbayya	PROPN
fnp-3806	3993	3	k	k	PROPN
fnp-3806	3993	4	,	,	PUNCT
fnp-3806	3993	5	puthanakar	puthanakar	PROPN
fnp-3806	3993	6	ny	ny	PROPN
fnp-3806	3993	7	,	,	PUNCT
fnp-3806	3993	8	naduwinmani	naduwinmani	PROPN
fnp-3806	3993	9	s	s	PROPN
fnp-3806	3993	10	,	,	PUNCT
fnp-3806	3993	11	et	et	PROPN
fnp-3806	3993	12	al	al	PROPN
fnp-3806	3993	13	.	.	PROPN
fnp-3806	3993	14	association	association	PROPN
fnp-3806	3993	15	between	between	ADP
fnp-3806	3993	16	periodontitis	periodontitis	NOUN
fnp-3806	3993	17	and	and	CCONJ
fnp-3806	3993	18	alzheimer	alzheimer	PROPN
fnp-3806	3993	19	’s	’s	PART
fnp-3806	3993	20	disease	disease	NOUN
fnp-3806	3993	21	.	.	PUNCT
fnp-3806	3994	1	j	j	PROPN
fnp-3806	3994	2	neuroimmunol	neuroimmunol	PROPN
fnp-3806	3994	3	2009;216:92	2009;216:92	NUM
fnp-3806	3994	4	-	-	SYM
fnp-3806	3994	5	7.doi	7.doi	PRON
fnp-3806	3994	6	:	:	PUNCT
fnp-3806	3994	7	10.1016	10.1016	NUM
fnp-3806	3994	8	/	/	SYM
fnp-3806	3994	9	j.jneuroim.2009.08.013	j.jneuroim.2009.08.013	PROPN
fnp-3806	3994	10	.	.	PUNCT
fnp-3806	3995	1	ide	ide	PROPN
fnp-3806	3995	2	m	m	PROPN
fnp-3806	3995	3	,	,	PUNCT
fnp-3806	3995	4	harris	harris	PROPN
fnp-3806	3995	5	m	m	PROPN
fnp-3806	3995	6	,	,	PUNCT
fnp-3806	3995	7	stevens	steven	VERB
fnp-3806	3995	8	a	a	PRON
fnp-3806	3995	9	,	,	PUNCT
fnp-3806	3995	10	et	et	PROPN
fnp-3806	3995	11	al	al	PROPN
fnp-3806	3995	12	.	.	PROPN
fnp-3806	3995	13	periodontitis	periodontitis	PROPN
fnp-3806	3995	14	and	and	CCONJ
fnp-3806	3995	15	cognitive	cognitive	ADJ
fnp-3806	3995	16	decline	decline	NOUN
fnp-3806	3995	17	in	in	ADP
fnp-3806	3995	18	alzheimer	alzheimer	PROPN
fnp-3806	3995	19	’s	’s	PART
fnp-3806	3995	20	disease	disease	NOUN
fnp-3806	3995	21	.	.	PUNCT
fnp-3806	3996	1	plos	plos	PROPN
fnp-3806	3996	2	one	one	NUM
fnp-3806	3996	3	2016;11	2016;11	NOUN
fnp-3806	3996	4	:	:	PUNCT
fnp-3806	3996	5	e0151081	e0151081	NOUN
fnp-3806	3996	6	.	.	PUNCT
fnp-3806	3997	1	https://doi.org/10.1016/j.jneuroim.2009.08.013	https://doi.org/10.1016/j.jneuroim.2009.08.013	VERB
fnp-3806	3997	2	alonso	alonso	PROPN
fnp-3806	3997	3	r	r	NOUN
fnp-3806	3997	4	,	,	PUNCT
fnp-3806	3997	5	pisa	pisa	PROPN
fnp-3806	3997	6	d	d	PROPN
fnp-3806	3997	7	,	,	PUNCT
fnp-3806	3997	8	rabano	rabano	PROPN
fnp-3806	3997	9	a	a	X
fnp-3806	3997	10	,	,	PUNCT
fnp-3806	3997	11	et	et	PROPN
fnp-3806	3997	12	al	al	PROPN
fnp-3806	3997	13	.	.	PROPN
fnp-3806	3997	14	alzheimer	alzheimer	PROPN
fnp-3806	3997	15	’s	’s	PART
fnp-3806	3997	16	disease	disease	NOUN
fnp-3806	3997	17	and	and	CCONJ
fnp-3806	3997	18	disseminated	disseminate	VERB
fnp-3806	3997	19	mycoses	mycose	NOUN
fnp-3806	3997	20	.	.	PUNCT
fnp-3806	3998	1	eur	eur	PROPN
fnp-3806	3998	2	j	j	PROPN
fnp-3806	3998	3	clin	clin	PROPN
fnp-3806	3998	4	microbiol	microbiol	PROPN
fnp-3806	3998	5	infect	infect	VERB
fnp-3806	3998	6	dis	dis	PROPN
fnp-3806	3998	7	2014b;33:1125	2014b;33:1125	PROPN
fnp-3806	3998	8	-	-	PUNCT
fnp-3806	3998	9	1132	1132	NUM
fnp-3806	3998	10	.	.	PUNCT
fnp-3806	3999	1	https://doi.org/10.1007/s10096-013-2045-z	https://doi.org/10.1007/s10096-013-2045-z	PROPN
fnp-3806	3999	2	pisa	pisa	PROPN
fnp-3806	3999	3	d	d	PROPN
fnp-3806	3999	4	,	,	PUNCT
fnp-3806	3999	5	alonso	alonso	PROPN
fnp-3806	3999	6	r	r	NOUN
fnp-3806	3999	7	,	,	PUNCT
fnp-3806	3999	8	rábano	rábano	PROPN
fnp-3806	3999	9	a	a	PRON
fnp-3806	3999	10	,	,	PUNCT
fnp-3806	3999	11	et	et	PROPN
fnp-3806	3999	12	al	al	PROPN
fnp-3806	3999	13	.	.	PUNCT
fnp-3806	4000	1	different	different	ADJ
fnp-3806	4000	2	brain	brain	NOUN
fnp-3806	4000	3	regions	region	NOUN
fnp-3806	4000	4	are	be	AUX
fnp-3806	4000	5	infected	infect	VERB
fnp-3806	4000	6	with	with	ADP
fnp-3806	4000	7	fungi	fungus	NOUN
fnp-3806	4000	8	in	in	ADP
fnp-3806	4000	9	alzheimer	alzheimer	PROPN
fnp-3806	4000	10	's	's	PART
fnp-3806	4000	11	disease	disease	NOUN
fnp-3806	4000	12	.	.	PUNCT
fnp-3806	4001	1	sci	sci	PROPN
fnp-3806	4001	2	rep	rep	PROPN
fnp-3806	4001	3	2015;5:15015	2015;5:15015	PROPN
fnp-3806	4001	4	.	.	PUNCT
fnp-3806	4002	1	https://doi.org/10.1038/srep15015	https://doi.org/10.1038/srep15015	PROPN
fnp-3806	4002	2	pisa	pisa	PROPN
fnp-3806	4002	3	d	d	PROPN
fnp-3806	4002	4	,	,	PUNCT
fnp-3806	4002	5	alonso	alonso	PROPN
fnp-3806	4002	6	r	r	NOUN
fnp-3806	4002	7	,	,	PUNCT
fnp-3806	4002	8	fernández	fernández	PROPN
fnp-3806	4002	9	-	-	PUNCT
fnp-3806	4002	10	fernández	fernández	PROPN
fnp-3806	4002	11	am	be	AUX
fnp-3806	4002	12	,	,	PUNCT
fnp-3806	4002	13	et	et	PROPN
fnp-3806	4002	14	al	al	PROPN
fnp-3806	4002	15	.	.	PUNCT
fnp-3806	4003	1	polymicrobial	polymicrobial	ADJ
fnp-3806	4003	2	infections	infection	NOUN
fnp-3806	4003	3	in	in	ADP
fnp-3806	4003	4	brain	brain	NOUN
fnp-3806	4003	5	tissuie	tissuie	NOUN
fnp-3806	4003	6	from	from	ADP
fnp-3806	4003	7	alzheimer	alzheimer	PROPN
fnp-3806	4003	8	’s	’s	PART
fnp-3806	4003	9	disease	disease	NOUN
fnp-3806	4003	10	patients	patient	NOUN
fnp-3806	4003	11	.	.	PUNCT
fnp-3806	4004	1	sci	sci	PROPN
fnp-3806	4004	2	rep	rep	PROPN
fnp-3806	4004	3	2017;7:5559	2017;7:5559	PROPN
fnp-3806	4004	4	.	.	PUNCT
fnp-3806	4005	1	https://doi.org/10.1038/s41598-017-05903-y	https://doi.org/10.1038/s41598-017-05903-y	PROPN
fnp-3806	4005	2	alonso	alonso	PROPN
fnp-3806	4005	3	r	r	PROPN
fnp-3806	4005	4	,	,	PUNCT
fnp-3806	4005	5	pisa	pisa	PROPN
fnp-3806	4005	6	d	d	PROPN
fnp-3806	4005	7	,	,	PUNCT
fnp-3806	4005	8	marina	marina	PROPN
fnp-3806	4005	9	a	a	PROPN
fnp-3806	4005	10	,	,	PUNCT
fnp-3806	4005	11	et	et	PROPN
fnp-3806	4005	12	al	al	PROPN
fnp-3806	4005	13	.	.	PROPN
fnp-3806	4005	14	fungal	fungal	ADJ
fnp-3806	4005	15	infection	infection	NOUN
fnp-3806	4005	16	in	in	ADP
fnp-3806	4005	17	patients	patient	NOUN
fnp-3806	4005	18	with	with	ADP
fnp-3806	4005	19	alzheimer	alzheimer	PROPN
fnp-3806	4005	20	’s	’s	PART
fnp-3806	4005	21	disease	disease	NOUN
fnp-3806	4005	22	.	.	PUNCT
fnp-3806	4006	1	j	j	PROPN
fnp-3806	4006	2	alzheimers	alzheimers	PROPN
fnp-3806	4006	3	dis	dis	PROPN
fnp-3806	4006	4	2014;41:301	2014;41:301	NOUN
fnp-3806	4006	5	-	-	SYM
fnp-3806	4006	6	311	311	NUM
fnp-3806	4006	7	.	.	PUNCT
fnp-3806	4007	1	https://doi.org/10.3233/jad-132681	https://doi.org/10.3233/jad-132681	VERB
fnp-3806	4007	2	alonso	alonso	PROPN
fnp-3806	4007	3	r	r	PROPN
fnp-3806	4007	4	,	,	PUNCT
fnp-3806	4007	5	pisa	pisa	PROPN
fnp-3806	4007	6	d	d	PROPN
fnp-3806	4007	7	,	,	PUNCT
fnp-3806	4007	8	marina	marina	PROPN
fnp-3806	4007	9	a	a	PROPN
fnp-3806	4007	10	,	,	PUNCT
fnp-3806	4007	11	et	et	PROPN
fnp-3806	4007	12	al	al	PROPN
fnp-3806	4007	13	.	.	PROPN
fnp-3806	4007	14	evidence	evidence	NOUN
fnp-3806	4007	15	for	for	ADP
fnp-3806	4007	16	fungal	fungal	ADJ
fnp-3806	4007	17	infection	infection	NOUN
fnp-3806	4007	18	in	in	ADP
fnp-3806	4007	19	cerebrospinal	cerebrospinal	ADJ
fnp-3806	4007	20	fluid	fluid	NOUN
fnp-3806	4007	21	and	and	CCONJ
fnp-3806	4007	22	brain	brain	NOUN
fnp-3806	4007	23	tissue	tissue	NOUN
fnp-3806	4007	24	from	from	ADP
fnp-3806	4007	25	patients	patient	NOUN
fnp-3806	4007	26	with	with	ADP
fnp-3806	4007	27	amyotrophic	amyotrophic	ADJ
fnp-3806	4007	28	lateral	lateral	ADJ
fnp-3806	4007	29	sclerosis	sclerosis	NOUN
fnp-3806	4007	30	.	.	PUNCT
fnp-3806	4008	1	int	int	PROPN
fnp-3806	4008	2	j	j	PROPN
fnp-3806	4008	3	biol	biol	PROPN
fnp-3806	4008	4	sci	sci	PROPN
fnp-3806	4008	5	2015;11:546	2015;11:546	PROPN
fnp-3806	4008	6	-	-	SYM
fnp-3806	4008	7	558	558	NUM
fnp-3806	4008	8	.	.	PUNCT
fnp-3806	4009	1	https://doi.org/10.7150/ijbs.11084	https://doi.org/10.7150/ijbs.11084	NOUN
fnp-3806	4009	2	alonso	alonso	PROPN
fnp-3806	4009	3	r	r	PROPN
fnp-3806	4009	4	,	,	PUNCT
fnp-3806	4009	5	pisa	pisa	PROPN
fnp-3806	4009	6	d	d	PROPN
fnp-3806	4009	7	,	,	PUNCT
fnp-3806	4009	8	aguado	aguado	NOUN
fnp-3806	4009	9	b	b	NOUN
fnp-3806	4009	10	,	,	PUNCT
fnp-3806	4009	11	et	et	PROPN
fnp-3806	4009	12	al	al	PROPN
fnp-3806	4009	13	.	.	PUNCT
fnp-3806	4010	1	identification	identification	NOUN
fnp-3806	4010	2	of	of	ADP
fnp-3806	4010	3	fungal	fungal	ADJ
fnp-3806	4010	4	species	specie	NOUN
fnp-3806	4010	5	in	in	ADP
fnp-3806	4010	6	brain	brain	NOUN
fnp-3806	4010	7	tissue	tissue	NOUN
fnp-3806	4010	8	from	from	ADP
fnp-3806	4010	9	alzheimer	alzheimer	PROPN
fnp-3806	4010	10	’s	’s	PART
fnp-3806	4010	11	disease	disease	NOUN
fnp-3806	4010	12	by	by	ADP
fnp-3806	4010	13	next	next	ADJ
fnp-3806	4010	14	-	-	PUNCT
fnp-3806	4010	15	generation	generation	NOUN
fnp-3806	4010	16	sequencing	sequencing	NOUN
fnp-3806	4010	17	.	.	PUNCT
fnp-3806	4011	1	j	j	PROPN
fnp-3806	4011	2	alzheimers	alzheimers	PROPN
fnp-3806	4011	3	dis	dis	PROPN
fnp-3806	4011	4	2017;58	2017;58	NUM
fnp-3806	4011	5	:	:	PUNCT
fnp-3806	4011	6	55	55	NUM
fnp-3806	4011	7	-	-	SYM
fnp-3806	4011	8	67	67	NUM
fnp-3806	4011	9	.	.	PUNCT
fnp-3806	4012	1	https://doi.org/10.3233/jad-170058	https://doi.org/10.3233/jad-170058	PROPN
fnp-3806	4012	2	pisa	pisa	PROPN
fnp-3806	4012	3	d	d	PROPN
fnp-3806	4012	4	,	,	PUNCT
fnp-3806	4012	5	alonso	alonso	PROPN
fnp-3806	4012	6	r	r	PROPN
fnp-3806	4012	7	,	,	PUNCT
fnp-3806	4012	8	marina	marina	NOUN
fnp-3806	4012	9	ai	ai	VERB
fnp-3806	4012	10	,	,	PUNCT
fnp-3806	4012	11	et	et	PROPN
fnp-3806	4012	12	al	al	PROPN
fnp-3806	4012	13	.	.	PROPN
fnp-3806	4013	1	human	human	ADJ
fnp-3806	4013	2	and	and	CCONJ
fnp-3806	4013	3	microbial	microbial	ADJ
fnp-3806	4013	4	proteins	protein	NOUN
fnp-3806	4013	5	from	from	ADP
fnp-3806	4013	6	corpora	corpora	PROPN
fnp-3806	4013	7	amylacea	amylacea	PROPN
fnp-3806	4013	8	of	of	ADP
fnp-3806	4013	9	alzheimer	alzheimer	PROPN
fnp-3806	4013	10	's	's	PART
fnp-3806	4013	11	disease	disease	NOUN
fnp-3806	4013	12	.	.	PUNCT
fnp-3806	4014	1	sci	sci	PROPN
fnp-3806	4014	2	rep	rep	PROPN
fnp-3806	4014	3	2018;8:9880	2018;8:9880	PROPN
fnp-3806	4014	4	.	.	PUNCT
fnp-3806	4015	1	https://doi.org/10.1038/s41598-018-28231-1	https://doi.org/10.1038/s41598-018-28231-1	PROPN
fnp-3806	4015	2	alonso	alonso	PROPN
fnp-3806	4015	3	r	r	PROPN
fnp-3806	4015	4	,	,	PUNCT
fnp-3806	4015	5	pisa	pisa	PROPN
fnp-3806	4015	6	d	d	PROPN
fnp-3806	4015	7	,	,	PUNCT
fnp-3806	4015	8	fernández	fernández	PROPN
fnp-3806	4015	9	-	-	PUNCT
fnp-3806	4015	10	fernández	fernández	PROPN
fnp-3806	4015	11	am	be	AUX
fnp-3806	4015	12	,	,	PUNCT
fnp-3806	4015	13	et	et	PROPN
fnp-3806	4015	14	al	al	PROPN
fnp-3806	4015	15	.	.	PROPN
fnp-3806	4015	16	fungal	fungal	ADJ
fnp-3806	4015	17	infection	infection	NOUN
fnp-3806	4015	18	in	in	ADP
fnp-3806	4015	19	neural	neural	ADJ
fnp-3806	4015	20	tissue	tissue	NOUN
fnp-3806	4015	21	of	of	ADP
fnp-3806	4015	22	patients	patient	NOUN
fnp-3806	4015	23	with	with	ADP
fnp-3806	4015	24	amyotrophic	amyotrophic	ADJ
fnp-3806	4015	25	lateral	lateral	ADJ
fnp-3806	4015	26	sclerosis	sclerosis	NOUN
fnp-3806	4015	27	.	.	PUNCT
fnp-3806	4016	1	neurobiol	neurobiol	PROPN
fnp-3806	4016	2	dis	dis	PROPN
fnp-3806	4016	3	2017;108:249	2017;108:249	NUM
fnp-3806	4016	4	-	-	SYM
fnp-3806	4016	5	260	260	NUM
fnp-3806	4016	6	.	.	PUNCT
fnp-3806	4017	1	https://doi.org/10.1016/j.nbd.2017.09.001	https://doi.org/10.1016/j.nbd.2017.09.001	PROPN
fnp-3806	4017	2	alonso	alonso	PROPN
fnp-3806	4017	3	r	r	PROPN
fnp-3806	4017	4	,	,	PUNCT
fnp-3806	4017	5	pisa	pisa	PROPN
fnp-3806	4017	6	d	d	PROPN
fnp-3806	4017	7	,	,	PUNCT
fnp-3806	4017	8	rábano	rábano	PROPN
fnp-3806	4017	9	a	a	PRON
fnp-3806	4017	10	,	,	PUNCT
fnp-3806	4017	11	et	et	PROPN
fnp-3806	4017	12	al	al	PROPN
fnp-3806	4017	13	.	.	PROPN
fnp-3806	4017	14	cerebrospinal	cerebrospinal	ADJ
fnp-3806	4017	15	fuid	fuid	NOUN
fnp-3806	4017	16	from	from	ADP
fnp-3806	4017	17	alzheimer	alzheimer	PROPN
fnp-3806	4017	18	’s	’s	PART
fnp-3806	4017	19	disease	disease	NOUN
fnp-3806	4017	20	patients	patient	NOUN
fnp-3806	4017	21	contains	contain	VERB
fnp-3806	4017	22	fungal	fungal	ADJ
fnp-3806	4017	23	proteins	protein	NOUN
fnp-3806	4017	24	and	and	CCONJ
fnp-3806	4017	25	dna	dna	NOUN
fnp-3806	4017	26	.	.	PUNCT
fnp-3806	4018	1	j	j	PROPN
fnp-3806	4018	2	alzheimers	alzheimers	PROPN
fnp-3806	4018	3	dis	dis	PROPN
fnp-3806	4018	4	2015;47:873	2015;47:873	NOUN
fnp-3806	4018	5	-	-	NUM
fnp-3806	4018	6	876	876	NUM
fnp-3806	4018	7	.	.	PUNCT
fnp-3806	4018	8	https://doi.org/10.3233/jad-150382	https://doi.org/10.3233/jad-150382	NUM
fnp-3806	4018	9	ball	ball	PROPN
fnp-3806	4018	10	mj	mj	PROPN
fnp-3806	4018	11	.	.	PUNCT
fnp-3806	4018	12	limbic	limbic	ADJ
fnp-3806	4018	13	predilection	predilection	NOUN
fnp-3806	4018	14	in	in	ADP
fnp-3806	4018	15	alzheimer	alzheimer	PROPN
fnp-3806	4018	16	dementia	dementia	PROPN
fnp-3806	4018	17	:	:	PUNCT
fnp-3806	4018	18	is	be	AUX
fnp-3806	4018	19	reactivated	reactivate	VERB
fnp-3806	4018	20	herpesvirus	herpesvirus	NOUN
fnp-3806	4018	21	involved	involve	VERB
fnp-3806	4018	22	?	?	PUNCT
fnp-3806	4019	1	can	can	AUX
fnp-3806	4019	2	j	j	PROPN
fnp-3806	4019	3	neurol	neurol	VERB
fnp-3806	4019	4	sci	sci	PROPN
fnp-3806	4019	5	j	j	PROPN
fnp-3806	4019	6	1982;9:303	1982;9:303	NUM
fnp-3806	4019	7	-	-	SYM
fnp-3806	4019	8	306	306	NUM
fnp-3806	4019	9	.	.	PUNCT
fnp-3806	4020	1	https://doi.org/10.1017/s0317167100044115	https://doi.org/10.1017/s0317167100044115	PROPN
fnp-3806	4020	2	gannicliffe	gannicliffe	PROPN
fnp-3806	4020	3	a	a	PROPN
fnp-3806	4020	4	,	,	PUNCT
fnp-3806	4020	5	sutton	sutton	PROPN
fnp-3806	4020	6	rn	rn	PROPN
fnp-3806	4020	7	,	,	PUNCT
fnp-3806	4020	8	itzhaki	itzhaki	ADJ
fnp-3806	4020	9	rf	rf	PROPN
fnp-3806	4020	10	.	.	PUNCT
fnp-3806	4020	11	viruses	virus	NOUN
fnp-3806	4020	12	,	,	PUNCT
fnp-3806	4020	13	brain	brain	NOUN
fnp-3806	4020	14	and	and	CCONJ
fnp-3806	4020	15	immunosuppression	immunosuppression	NOUN
fnp-3806	4020	16	.	.	PUNCT
fnp-3806	4021	1	psychol	psychol	PROPN
fnp-3806	4021	2	med	med	PROPN
fnp-3806	4021	3	1986;16:247	1986;16:247	PROPN
fnp-3806	4021	4	-	-	SYM
fnp-3806	4021	5	249	249	NUM
fnp-3806	4021	6	.	.	PUNCT
fnp-3806	4022	1	https://doi.org/10.1017/s0033291700009053	https://doi.org/10.1017/s0033291700009053	NUM
fnp-3806	4022	2	lin	lin	PROPN
fnp-3806	4022	3	w	w	PROPN
fnp-3806	4022	4	-	-	PUNCT
fnp-3806	4022	5	r	r	NOUN
fnp-3806	4022	6	,	,	PUNCT
fnp-3806	4022	7	wozniak	wozniak	PROPN
fnp-3806	4022	8	ma	ma	PROPN
fnp-3806	4022	9	,	,	PUNCT
fnp-3806	4022	10	cooper	cooper	PROPN
fnp-3806	4022	11	rj	rj	PROPN
fnp-3806	4022	12	,	,	PUNCT
fnp-3806	4022	13	et	et	PROPN
fnp-3806	4022	14	al	al	PROPN
fnp-3806	4022	15	.	.	PUNCT
fnp-3806	4022	16	herpesviruses	herpesviruse	NOUN
fnp-3806	4022	17	in	in	ADP
fnp-3806	4022	18	brain	brain	NOUN
fnp-3806	4022	19	and	and	CCONJ
fnp-3806	4022	20	alzheimer	alzheimer	PROPN
fnp-3806	4022	21	’s	’s	PART
fnp-3806	4022	22	disease	disease	NOUN
fnp-3806	4022	23	.	.	PUNCT
fnp-3806	4023	1	j	j	PROPN
fnp-3806	4023	2	pathol	pathol	PROPN
fnp-3806	4023	3	2002;197:395	2002;197:395	PROPN
fnp-3806	4023	4	-	-	SYM
fnp-3806	4023	5	402	402	NUM
fnp-3806	4023	6	.	.	PUNCT
fnp-3806	4024	1	https://doi.org/10.1002/path.1127	https://doi.org/10.1002/path.1127	NOUN
fnp-3806	4024	2	hemling	hemling	PROPN
fnp-3806	4024	3	n	n	CCONJ
fnp-3806	4024	4	,	,	PUNCT
fnp-3806	4024	5	röyttä	röyttä	ADV
fnp-3806	4024	6	m	m	PROPN
fnp-3806	4024	7	,	,	PUNCT
fnp-3806	4024	8	rinne	rinne	PROPN
fnp-3806	4024	9	j	j	PROPN
fnp-3806	4024	10	,	,	PUNCT
fnp-3806	4024	11	et	et	PROPN
fnp-3806	4024	12	al	al	PROPN
fnp-3806	4024	13	.	.	PUNCT
fnp-3806	4025	1	herpesviruses	herpesviruse	NOUN
fnp-3806	4025	2	in	in	ADP
fnp-3806	4025	3	brains	brain	NOUN
fnp-3806	4025	4	in	in	ADP
fnp-3806	4025	5	alzheimer	alzheimer	PROPN
fnp-3806	4025	6	’s	’s	PART
fnp-3806	4025	7	and	and	CCONJ
fnp-3806	4025	8	parkinson	parkinson	NOUN
fnp-3806	4025	9	’s	’s	PART
fnp-3806	4025	10	diseases	disease	NOUN
fnp-3806	4025	11	.	.	PUNCT
fnp-3806	4026	1	ann	ann	PROPN
fnp-3806	4026	2	neurol	neurol	PROPN
fnp-3806	4026	3	2003	2003	NUM
fnp-3806	4026	4	;	;	PUNCT
fnp-3806	4026	5	54	54	NUM
fnp-3806	4026	6	:	:	PUNCT
fnp-3806	4026	7	267	267	NUM
fnp-3806	4026	8	-	-	SYM
fnp-3806	4026	9	271	271	NUM
fnp-3806	4026	10	.	.	PUNCT
fnp-3806	4027	1	https://doi.org/10.1002/ana.10662	https://doi.org/10.1002/ana.10662	PROPN
fnp-3806	4027	2	warren	warren	NOUN
fnp-3806	4027	3	-	-	PUNCT
fnp-3806	4027	4	gash	gash	NOUN
fnp-3806	4027	5	c	c	NOUN
fnp-3806	4027	6	,	,	PUNCT
fnp-3806	4027	7	forbes	forbes	PROPN
fnp-3806	4027	8	hj	hj	PROPN
fnp-3806	4027	9	,	,	PUNCT
fnp-3806	4027	10	williamson	williamson	PROPN
fnp-3806	4027	11	e	e	PROPN
fnp-3806	4027	12	,	,	PUNCT
fnp-3806	4027	13	et	et	PROPN
fnp-3806	4027	14	al	al	PROPN
fnp-3806	4027	15	.	.	PUNCT
fnp-3806	4028	1	human	human	ADJ
fnp-3806	4028	2	herpesvirus	herpesvirus	NOUN
fnp-3806	4028	3	infections	infection	NOUN
fnp-3806	4028	4	and	and	CCONJ
fnp-3806	4028	5	dementia	dementia	NOUN
fnp-3806	4028	6	or	or	CCONJ
fnp-3806	4028	7	mild	mild	ADJ
fnp-3806	4028	8	cognitive	cognitive	ADJ
fnp-3806	4028	9	impairment	impairment	NOUN
fnp-3806	4028	10	:	:	PUNCT
fnp-3806	4028	11	a	a	DET
fnp-3806	4028	12	systematic	systematic	ADJ
fnp-3806	4028	13	review	review	NOUN
fnp-3806	4028	14	and	and	CCONJ
fnp-3806	4028	15	meta	meta	ADJ
fnp-3806	4028	16	-	-	PUNCT
fnp-3806	4028	17	analysis	analysis	NOUN
fnp-3806	4028	18	.	.	PUNCT
fnp-3806	4029	1	sci	sci	PROPN
fnp-3806	4029	2	rep	rep	PROPN
fnp-3806	4029	3	2019;9:4743	2019;9:4743	NUM
fnp-3806	4029	4	.	.	PUNCT
fnp-3806	4030	1	https://doi.org/10.1038/s41598-019-41218-w	https://doi.org/10.1038/s41598-019-41218-w	PROPN
fnp-3806	4030	2	jamieson	jamieson	PROPN
fnp-3806	4030	3	ga	ga	PROPN
fnp-3806	4030	4	,	,	PUNCT
fnp-3806	4030	5	maitland	maitland	PROPN
fnp-3806	4030	6	nj	nj	PROPN
fnp-3806	4030	7	,	,	PUNCT
fnp-3806	4030	8	wilcock	wilcock	PROPN
fnp-3806	4030	9	gk	gk	PROPN
fnp-3806	4030	10	,	,	PUNCT
fnp-3806	4030	11	et	et	PROPN
fnp-3806	4030	12	al	al	PROPN
fnp-3806	4030	13	.	.	PROPN
fnp-3806	4030	14	latent	latent	PROPN
fnp-3806	4030	15	herpes	herpe	NOUN
fnp-3806	4030	16	simplex	simplex	NOUN
fnp-3806	4030	17	virus	virus	NOUN
fnp-3806	4030	18	type	type	NOUN
fnp-3806	4030	19	1	1	NUM
fnp-3806	4030	20	in	in	ADP
fnp-3806	4030	21	normal	normal	ADJ
fnp-3806	4030	22	and	and	CCONJ
fnp-3806	4030	23	alzheimer	alzheimer	PROPN
fnp-3806	4030	24	’s	’s	PART
fnp-3806	4030	25	disease	disease	NOUN
fnp-3806	4030	26	brains	brain	VERB
fnp-3806	4030	27	.	.	PUNCT
fnp-3806	4031	1	j	j	PROPN
fnp-3806	4031	2	med	med	PROPN
fnp-3806	4031	3	virol	virol	NOUN
fnp-3806	4031	4	1991;33:224	1991;33:224	NUM
fnp-3806	4031	5	-	-	SYM
fnp-3806	4031	6	227	227	NUM
fnp-3806	4031	7	.	.	PUNCT
fnp-3806	4032	1	https://doi.org/10.1002/jmv.1890330403	https://doi.org/10.1002/jmv.1890330403	NOUN
fnp-3806	4032	2	itzhaki	itzhaki	ADJ
fnp-3806	4032	3	rf	rf	NOUN
fnp-3806	4032	4	,	,	PUNCT
fnp-3806	4032	5	lin	lin	PROPN
fnp-3806	4032	6	wr	wr	PROPN
fnp-3806	4032	7	,	,	PUNCT
fnp-3806	4032	8	shang	shang	PROPN
fnp-3806	4032	9	d	d	PROPN
fnp-3806	4032	10	,	,	PUNCT
fnp-3806	4032	11	et	et	PROPN
fnp-3806	4032	12	al	al	PROPN
fnp-3806	4032	13	.	.	PROPN
fnp-3806	4032	14	herpes	herpe	NOUN
fnp-3806	4032	15	simplex	simplex	NOUN
fnp-3806	4032	16	virus	virus	NOUN
fnp-3806	4032	17	type	type	NOUN
fnp-3806	4032	18	1	1	NUM
fnp-3806	4032	19	in	in	ADP
fnp-3806	4032	20	brain	brain	NOUN
fnp-3806	4032	21	and	and	CCONJ
fnp-3806	4032	22	risk	risk	NOUN
fnp-3806	4032	23	of	of	ADP
fnp-3806	4032	24	alzheimer	alzheimer	PROPN
fnp-3806	4032	25	’s	’s	PART
fnp-3806	4032	26	disease	disease	NOUN
fnp-3806	4032	27	.	.	PUNCT
fnp-3806	4033	1	lancet	lancet	PROPN
fnp-3806	4033	2	1997;349:241	1997;349:241	NUM
fnp-3806	4033	3	-	-	SYM
fnp-3806	4033	4	244	244	NUM
fnp-3806	4033	5	.	.	PUNCT
fnp-3806	4034	1	https://doi.org/10.1016/s0140-6736(96)10149-5	https://doi.org/10.1016/s0140-6736(96)10149-5	PROPN
fnp-3806	4034	2	harris	harris	PROPN
fnp-3806	4034	3	sa	sa	PROPN
fnp-3806	4034	4	,	,	PUNCT
fnp-3806	4034	5	harris	harris	PROPN
fnp-3806	4034	6	ea	ea	PROPN
fnp-3806	4034	7	.	.	PUNCT
fnp-3806	4034	8	herpes	herpe	NOUN
fnp-3806	4034	9	simplex	simplex	NOUN
fnp-3806	4034	10	virus	virus	NOUN
fnp-3806	4034	11	type	type	NOUN
fnp-3806	4034	12	1	1	NUM
fnp-3806	4034	13	and	and	CCONJ
fnp-3806	4034	14	other	other	ADJ
fnp-3806	4034	15	pathogens	pathogen	NOUN
fnp-3806	4034	16	are	be	AUX
fnp-3806	4034	17	key	key	ADJ
fnp-3806	4034	18	causative	causative	ADJ
fnp-3806	4034	19	factors	factor	NOUN
fnp-3806	4034	20	in	in	ADP
fnp-3806	4034	21	sporadic	sporadic	ADJ
fnp-3806	4034	22	alzheimer	alzheimer	PROPN
fnp-3806	4034	23	's	's	PART
fnp-3806	4034	24	disease	disease	NOUN
fnp-3806	4034	25	.	.	PUNCT
fnp-3806	4035	1	j	j	PROPN
fnp-3806	4035	2	alzheimers	alzheimers	PROPN
fnp-3806	4035	3	dis	dis	PROPN
fnp-3806	4035	4	2015;48:319	2015;48:319	PROPN
fnp-3806	4035	5	-	-	PUNCT
fnp-3806	4035	6	353	353	NUM
fnp-3806	4035	7	.	.	NOUN
fnp-3806	4035	8	https://doi.org/10.3233/jad-142853	https://doi.org/10.3233/jad-142853	PROPN
fnp-3806	4035	9	lövheim	lövheim	PROPN
fnp-3806	4035	10	h	h	PROPN
fnp-3806	4035	11	,	,	PUNCT
fnp-3806	4035	12	gilthorpe	gilthorpe	PROPN
fnp-3806	4035	13	j	j	PROPN
fnp-3806	4035	14	,	,	PUNCT
fnp-3806	4035	15	johansson	johansson	PROPN
fnp-3806	4035	16	a	a	PROPN
fnp-3806	4035	17	,	,	PUNCT
fnp-3806	4035	18	et	et	PROPN
fnp-3806	4035	19	al	al	PROPN
fnp-3806	4035	20	.	.	PROPN
fnp-3806	4035	21	herpes	herpe	NOUN
fnp-3806	4035	22	simplex	simplex	NOUN
fnp-3806	4035	23	infection	infection	NOUN
fnp-3806	4035	24	and	and	CCONJ
fnp-3806	4035	25	the	the	DET
fnp-3806	4035	26	risk	risk	NOUN
fnp-3806	4035	27	of	of	ADP
fnp-3806	4035	28	alzheimer	alzheimer	PROPN
fnp-3806	4035	29	’s	’s	PART
fnp-3806	4035	30	disease	disease	NOUN
fnp-3806	4035	31	:	:	PUNCT
fnp-3806	4035	32	a	a	DET
fnp-3806	4035	33	nested	nested	ADJ
fnp-3806	4035	34	case	case	NOUN
fnp-3806	4035	35	-	-	PUNCT
fnp-3806	4035	36	control	control	NOUN
fnp-3806	4035	37	study	study	NOUN
fnp-3806	4035	38	.	.	PUNCT
fnp-3806	4036	1	alzheimers	alzheimers	PROPN
fnp-3806	4036	2	dement	dement	PROPN
fnp-3806	4036	3	2015;11:587	2015;11:587	PROPN
fnp-3806	4036	4	-	-	SYM
fnp-3806	4036	5	592	592	NUM
fnp-3806	4036	6	.	.	PUNCT
fnp-3806	4037	1	https://doi.org/10.1016/j.jalz.2014.07.157	https://doi.org/10.1016/j.jalz.2014.07.157	NOUN
fnp-3806	4037	2	itzhaki	itzhaki	ADJ
fnp-3806	4037	3	rf	rf	PROPN
fnp-3806	4037	4	.	.	PROPN
fnp-3806	4037	5	corroboration	corroboration	NOUN
fnp-3806	4037	6	of	of	ADP
fnp-3806	4037	7	a	a	DET
fnp-3806	4037	8	major	major	ADJ
fnp-3806	4037	9	role	role	NOUN
fnp-3806	4037	10	for	for	ADP
fnp-3806	4037	11	herpes	herpe	NOUN
fnp-3806	4037	12	simplex	simplex	NOUN
fnp-3806	4037	13	virus	virus	NOUN
fnp-3806	4037	14	type	type	NOUN
fnp-3806	4037	15	1	1	NUM
fnp-3806	4037	16	in	in	ADP
fnp-3806	4037	17	alzheimer	alzheimer	PROPN
fnp-3806	4037	18	’s	’s	PART
fnp-3806	4037	19	disease	disease	NOUN
fnp-3806	4037	20	.	.	PUNCT
fnp-3806	4038	1	front	front	ADJ
fnp-3806	4038	2	aging	age	VERB
fnp-3806	4038	3	neurosci	neurosci	NOUN
fnp-3806	4038	4	2018;10:324	2018;10:324	PROPN
fnp-3806	4038	5	.	.	PUNCT
fnp-3806	4039	1	https://doi.org/10.3389/fnagi.2018.00324	https://doi.org/10.3389/fnagi.2018.00324	PROPN
fnp-3806	4039	2	wozniak	wozniak	PROPN
fnp-3806	4039	3	m	m	PROPN
fnp-3806	4039	4	,	,	PUNCT
fnp-3806	4039	5	mee	mee	PROPN
fnp-3806	4039	6	a	a	PRON
fnp-3806	4039	7	,	,	PUNCT
fnp-3806	4039	8	itzhaki	itzhaki	PROPN
fnp-3806	4039	9	r.	r.	PROPN
fnp-3806	4039	10	herpes	herpe	NOUN
fnp-3806	4039	11	simplex	simplex	NOUN
fnp-3806	4039	12	virus	virus	NOUN
fnp-3806	4039	13	type	type	NOUN
fnp-3806	4039	14	1	1	NUM
fnp-3806	4039	15	dna	dna	NOUN
fnp-3806	4039	16	is	be	AUX
fnp-3806	4039	17	located	locate	VERB
fnp-3806	4039	18	within	within	ADP
fnp-3806	4039	19	alzheimer	alzheimer	PROPN
fnp-3806	4039	20	’s	’s	PART
fnp-3806	4039	21	disease	disease	NOUN
fnp-3806	4039	22	amyloid	amyloid	NOUN
fnp-3806	4039	23	plaques	plaque	NOUN
fnp-3806	4039	24	.	.	PUNCT
fnp-3806	4040	1	j	j	PROPN
fnp-3806	4040	2	pathol	pathol	NOUN
fnp-3806	4040	3	2009;217:131	2009;217:131	PROPN
fnp-3806	4040	4	-	-	SYM
fnp-3806	4040	5	138	138	NUM
fnp-3806	4040	6	.	.	PUNCT
fnp-3806	4041	1	https://doi.org/10.1002/path.2449	https://doi.org/10.1002/path.2449	PROPN
fnp-3806	4041	2	lai	lai	PROPN
fnp-3806	4041	3	sw	sw	PROPN
fnp-3806	4041	4	,	,	PUNCT
fnp-3806	4041	5	kuo	kuo	PROPN
fnp-3806	4041	6	yh	yh	PROPN
fnp-3806	4041	7	,	,	PUNCT
fnp-3806	4041	8	liao	liao	PROPN
fnp-3806	4041	9	kf	kf	PROPN
fnp-3806	4041	10	.	.	PROPN
fnp-3806	4041	11	herpes	herpe	NOUN
fnp-3806	4041	12	zoster	zoster	PROPN
fnp-3806	4041	13	and	and	CCONJ
fnp-3806	4041	14	alzheimer	alzheimer	PROPN
fnp-3806	4041	15	's	's	PART
fnp-3806	4041	16	disease	disease	NOUN
fnp-3806	4041	17	.	.	PUNCT
fnp-3806	4042	1	eur	eur	PROPN
fnp-3806	4042	2	arch	arch	PROPN
fnp-3806	4042	3	psychiatry	psychiatry	PROPN
fnp-3806	4042	4	clin	clin	PROPN
fnp-3806	4042	5	neurosci	neurosci	PROPN
fnp-3806	4042	6	2021	2021	NUM
fnp-3806	4042	7	jul	jul	PROPN
fnp-3806	4042	8	23	23	NUM
fnp-3806	4042	9	.	.	PUNCT
fnp-3806	4043	1	https://doi.org/10.1007/s00406-021-01311-6	https://doi.org/10.1007/s00406-021-01311-6	PROPN
fnp-3806	4043	2	barnes	barnes	PROPN
fnp-3806	4043	3	ll	ll	AUX
fnp-3806	4043	4	,	,	PUNCT
fnp-3806	4043	5	capuano	capuano	PROPN
fnp-3806	4043	6	aw	aw	PROPN
fnp-3806	4043	7	,	,	PUNCT
fnp-3806	4043	8	aiello	aiello	PROPN
fnp-3806	4043	9	ae	ae	PROPN
fnp-3806	4043	10	,	,	PUNCT
fnp-3806	4043	11	et	et	PROPN
fnp-3806	4043	12	al	al	PROPN
fnp-3806	4043	13	.	.	PUNCT
fnp-3806	4043	14	cytomegalovirus	cytomegalovirus	NOUN
fnp-3806	4043	15	infection	infection	NOUN
fnp-3806	4043	16	and	and	CCONJ
fnp-3806	4043	17	risk	risk	NOUN
fnp-3806	4043	18	of	of	ADP
fnp-3806	4043	19	alzheimer	alzheimer	PROPN
fnp-3806	4043	20	disease	disease	NOUN
fnp-3806	4043	21	in	in	ADP
fnp-3806	4043	22	older	old	ADJ
fnp-3806	4043	23	black	black	ADJ
fnp-3806	4043	24	and	and	CCONJ
fnp-3806	4043	25	white	white	ADJ
fnp-3806	4043	26	individuals	individual	NOUN
fnp-3806	4043	27	.	.	PUNCT
fnp-3806	4044	1	j	j	PROPN
fnp-3806	4044	2	infect	infect	VERB
fnp-3806	4044	3	dis	dis	PROPN
fnp-3806	4044	4	2015;211:230	2015;211:230	NUM
fnp-3806	4044	5	-	-	SYM
fnp-3806	4044	6	237	237	NUM
fnp-3806	4044	7	.	.	PUNCT
fnp-3806	4045	1	https://doi.org/10.1093/infdis/jiu437	https://doi.org/10.1093/infdis/jiu437	PROPN
fnp-3806	4045	2	fotheringham	fotheringham	PROPN
fnp-3806	4045	3	j	j	PROPN
fnp-3806	4045	4	,	,	PUNCT
fnp-3806	4045	5	akhyani	akhyani	X
fnp-3806	4045	6	n	n	CCONJ
fnp-3806	4045	7	,	,	PUNCT
fnp-3806	4045	8	vortmeyer	vortmeyer	NOUN
fnp-3806	4045	9	a	a	NOUN
fnp-3806	4045	10	,	,	PUNCT
fnp-3806	4045	11	et	et	PROPN
fnp-3806	4045	12	al	al	PROPN
fnp-3806	4045	13	.	.	PUNCT
fnp-3806	4045	14	detection	detection	NOUN
fnp-3806	4045	15	of	of	ADP
fnp-3806	4045	16	active	active	ADJ
fnp-3806	4045	17	human	human	ADJ
fnp-3806	4045	18	herpesvirus–6	herpesvirus–6	PROPN
fnp-3806	4045	19	infection	infection	NOUN
fnp-3806	4045	20	in	in	ADP
fnp-3806	4045	21	the	the	DET
fnp-3806	4045	22	brain	brain	NOUN
fnp-3806	4045	23	:	:	PUNCT
fnp-3806	4045	24	correlation	correlation	NOUN
fnp-3806	4045	25	with	with	ADP
fnp-3806	4045	26	polymerase	polymerase	NOUN
fnp-3806	4045	27	chain	chain	NOUN
fnp-3806	4045	28	reaction	reaction	NOUN
fnp-3806	4045	29	detection	detection	NOUN
fnp-3806	4045	30	in	in	ADP
fnp-3806	4045	31	cerebrospinal	cerebrospinal	ADJ
fnp-3806	4045	32	fluid	fluid	NOUN
fnp-3806	4045	33	.	.	PUNCT
fnp-3806	4046	1	j	j	PROPN
fnp-3806	4046	2	infect	infect	VERB
fnp-3806	4046	3	dis	dis	PROPN
fnp-3806	4046	4	2007;195:450	2007;195:450	NUM
fnp-3806	4046	5	-	-	SYM
fnp-3806	4046	6	454	454	NUM
fnp-3806	4046	7	.	.	PUNCT
fnp-3806	4047	1	https://doi.org/10.1086/510757	https://doi.org/10.1086/510757	PROPN
fnp-3806	4047	2	readhead	readhead	ADJ
fnp-3806	4047	3	b	b	NOUN
fnp-3806	4047	4	,	,	PUNCT
fnp-3806	4047	5	haure	haure	NOUN
fnp-3806	4047	6	-	-	PUNCT
fnp-3806	4047	7	mirande	mirande	NOUN
fnp-3806	4047	8	jv	jv	NOUN
fnp-3806	4047	9	,	,	PUNCT
fnp-3806	4047	10	funk	funk	NOUN
fnp-3806	4047	11	cc	cc	NOUN
fnp-3806	4047	12	,	,	PUNCT
fnp-3806	4047	13	et	et	PROPN
fnp-3806	4047	14	al	al	PROPN
fnp-3806	4047	15	.	.	PROPN
fnp-3806	4048	1	multiscale	multiscale	ADJ
fnp-3806	4048	2	analysis	analysis	NOUN
fnp-3806	4048	3	of	of	ADP
fnp-3806	4048	4	independent	independent	ADJ
fnp-3806	4048	5	alzheimer	alzheimer	PROPN
fnp-3806	4048	6	’s	’s	PART
fnp-3806	4048	7	cohorts	cohort	NOUN
fnp-3806	4048	8	finds	find	VERB
fnp-3806	4048	9	disruption	disruption	NOUN
fnp-3806	4048	10	of	of	ADP
fnp-3806	4048	11	molecular	molecular	ADJ
fnp-3806	4048	12	,	,	PUNCT
fnp-3806	4048	13	genetic	genetic	ADJ
fnp-3806	4048	14	,	,	PUNCT
fnp-3806	4048	15	and	and	CCONJ
fnp-3806	4048	16	clinical	clinical	ADJ
fnp-3806	4048	17	networks	network	NOUN
fnp-3806	4048	18	by	by	ADP
fnp-3806	4048	19	human	human	ADJ
fnp-3806	4048	20	herpesvirus	herpesvirus	NOUN
fnp-3806	4048	21	.	.	PUNCT
fnp-3806	4049	1	neuron	neuron	PROPN
fnp-3806	4049	2	2018;99:64	2018;99:64	PROPN
fnp-3806	4049	3	-	-	PUNCT
fnp-3806	4049	4	82.e7	82.e7	NUM
fnp-3806	4049	5	.	.	PUNCT
fnp-3806	4050	1	https://doi.org/10.1016/j.neuron.2018.05.023	https://doi.org/10.1016/j.neuron.2018.05.023	NUM
fnp-3806	4050	2	allnutt	allnutt	PROPN
fnp-3806	4050	3	ma	ma	PROPN
fnp-3806	4050	4	,	,	PUNCT
fnp-3806	4050	5	johnson	johnson	PROPN
fnp-3806	4050	6	k	k	PROPN
fnp-3806	4050	7	,	,	PUNCT
fnp-3806	4050	8	bennett	bennett	PROPN
fnp-3806	4050	9	da	da	PROPN
fnp-3806	4050	10	,	,	PUNCT
fnp-3806	4050	11	et	et	PROPN
fnp-3806	4050	12	al	al	PROPN
fnp-3806	4050	13	.	.	PUNCT
fnp-3806	4051	1	human	human	ADJ
fnp-3806	4051	2	herpesvirus	herpesvirus	NOUN
fnp-3806	4051	3	6	6	NUM
fnp-3806	4051	4	detection	detection	NOUN
fnp-3806	4051	5	in	in	ADP
fnp-3806	4051	6	alzheimer	alzheimer	PROPN
fnp-3806	4051	7	’s	’s	PART
fnp-3806	4051	8	disease	disease	NOUN
fnp-3806	4051	9	cases	case	NOUN
fnp-3806	4051	10	and	and	CCONJ
fnp-3806	4051	11	controls	control	NOUN
fnp-3806	4051	12	across	across	ADP
fnp-3806	4051	13	multiple	multiple	ADJ
fnp-3806	4051	14	cohorts	cohort	NOUN
fnp-3806	4051	15	.	.	PUNCT
fnp-3806	4052	1	neuron	neuron	PROPN
fnp-3806	4052	2	2000	2000	NUM
fnp-3806	4052	3	;	;	PUNCT
fnp-3806	4052	4	105:1027	105:1027	NUM
fnp-3806	4052	5	-	-	SYM
fnp-3806	4052	6	1035	1035	NUM
fnp-3806	4052	7	.	.	PUNCT
fnp-3806	4053	1	https://doi.org/10.1016/j.neuron.2019.12.031	https://doi.org/10.1016/j.neuron.2019.12.031	NOUN
fnp-3806	4053	2	santpere	santpere	ADP
fnp-3806	4053	3	g	g	PROPN
fnp-3806	4053	4	,	,	PUNCT
fnp-3806	4053	5	telford	telford	PROPN
fnp-3806	4053	6	m	m	PROPN
fnp-3806	4053	7	,	,	PUNCT
fnp-3806	4053	8	andrés	andrés	PROPN
fnp-3806	4053	9	-	-	PUNCT
fnp-3806	4053	10	benito	benito	PROPN
fnp-3806	4053	11	p	p	PROPN
fnp-3806	4053	12	,	,	PUNCT
fnp-3806	4053	13	et	et	PROPN
fnp-3806	4053	14	al	al	PROPN
fnp-3806	4053	15	.	.	PUNCT
fnp-3806	4054	1	the	the	DET
fnp-3806	4054	2	presence	presence	NOUN
fnp-3806	4054	3	of	of	ADP
fnp-3806	4054	4	human	human	ADJ
fnp-3806	4054	5	herpesvirus	herpesvirus	NOUN
fnp-3806	4054	6	6	6	NUM
fnp-3806	4054	7	in	in	ADP
fnp-3806	4054	8	the	the	DET
fnp-3806	4054	9	brain	brain	NOUN
fnp-3806	4054	10	in	in	ADP
fnp-3806	4054	11	health	health	NOUN
fnp-3806	4054	12	and	and	CCONJ
fnp-3806	4054	13	disease	disease	NOUN
fnp-3806	4054	14	.	.	PUNCT
fnp-3806	4055	1	biomolecules	biomolecule	NOUN
fnp-3806	4055	2	2020;10:1520	2020;10:1520	NUM
fnp-3806	4055	3	.	.	PUNCT
fnp-3806	4056	1	https://doi.org/10.3390/biom10111520	https://doi.org/10.3390/biom10111520	PROPN
fnp-3806	4056	2	rodriguez	rodriguez	PROPN
fnp-3806	4056	3	jd	jd	PROPN
fnp-3806	4056	4	,	,	PUNCT
fnp-3806	4056	5	royall	royall	NOUN
fnp-3806	4056	6	d	d	PROPN
fnp-3806	4056	7	,	,	PUNCT
fnp-3806	4056	8	daum	daum	PROPN
fnp-3806	4056	9	lt	lt	PROPN
fnp-3806	4056	10	,	,	PUNCT
fnp-3806	4056	11	et	et	PROPN
fnp-3806	4056	12	al	al	PROPN
fnp-3806	4056	13	.	.	PROPN
fnp-3806	4056	14	amplification	amplification	NOUN
fnp-3806	4056	15	of	of	ADP
fnp-3806	4056	16	herpes	herpe	NOUN
fnp-3806	4056	17	simplex	simplex	NOUN
fnp-3806	4056	18	type	type	NOUN
fnp-3806	4056	19	1	1	NUM
fnp-3806	4056	20	and	and	CCONJ
fnp-3806	4056	21	human	human	ADJ
fnp-3806	4056	22	herpes	herpe	NOUN
fnp-3806	4056	23	type	type	NOUN
fnp-3806	4056	24	5	5	NUM
fnp-3806	4056	25	viral	viral	ADJ
fnp-3806	4056	26	dna	dna	NOUN
fnp-3806	4056	27	from	from	ADP
fnp-3806	4056	28	formalin	formalin	NOUN
fnp-3806	4056	29	-	-	PUNCT
fnp-3806	4056	30	fxed	fxe	VERB
fnp-3806	4056	31	alzheimer	alzheimer	NOUN
fnp-3806	4056	32	brain	brain	NOUN
fnp-3806	4056	33	tissue	tissue	NOUN
fnp-3806	4056	34	.	.	PUNCT
fnp-3806	4057	1	neurosci	neurosci	PROPN
fnp-3806	4057	2	lett	lett	PROPN
fnp-3806	4057	3	2005;390:37	2005;390:37	NUM
fnp-3806	4057	4	-	-	SYM
fnp-3806	4057	5	41	41	NUM
fnp-3806	4057	6	.	.	PUNCT
fnp-3806	4058	1	https://doi.org/10.1016/j.neulet.2005.07.052	https://doi.org/10.1016/j.neulet.2005.07.052	PRON
fnp-3806	4058	2	carbone	carbone	NOUN
fnp-3806	4058	3	i	i	PRON
fnp-3806	4058	4	,	,	PUNCT
fnp-3806	4058	5	lazzarotto	lazzarotto	ADJ
fnp-3806	4058	6	t	t	PROPN
fnp-3806	4058	7	,	,	PUNCT
fnp-3806	4058	8	ianni	ianni	PROPN
fnp-3806	4058	9	m	m	PROPN
fnp-3806	4058	10	,	,	PUNCT
fnp-3806	4058	11	et	et	PROPN
fnp-3806	4058	12	al	al	PROPN
fnp-3806	4058	13	.	.	PROPN
fnp-3806	4058	14	herpes	herpe	NOUN
fnp-3806	4058	15	virus	virus	NOUN
fnp-3806	4058	16	in	in	ADP
fnp-3806	4058	17	alzheimer	alzheimer	PROPN
fnp-3806	4058	18	’s	’s	PART
fnp-3806	4058	19	disease	disease	NOUN
fnp-3806	4058	20	:	:	PUNCT
fnp-3806	4058	21	relation	relation	NOUN
fnp-3806	4058	22	to	to	ADP
fnp-3806	4058	23	progression	progression	NOUN
fnp-3806	4058	24	of	of	ADP
fnp-3806	4058	25	the	the	DET
fnp-3806	4058	26	disease	disease	NOUN
fnp-3806	4058	27	.	.	PUNCT
fnp-3806	4059	1	neurobiol	neurobiol	PROPN
fnp-3806	4059	2	aging	age	VERB
fnp-3806	4059	3	2014;35:122	2014;35:122	PROPN
fnp-3806	4059	4	-	-	SYM
fnp-3806	4059	5	129	129	NUM
fnp-3806	4059	6	.	.	PUNCT
fnp-3806	4060	1	https://doi.org/10.1016/j.neurobiolaging.2013.06.024	https://doi.org/10.1016/j.neurobiolaging.2013.06.024	NOUN
fnp-3806	4060	2	eimer	eimer	PROPN
fnp-3806	4060	3	wa	wa	PROPN
fnp-3806	4060	4	,	,	PUNCT
fnp-3806	4060	5	vijaya	vijaya	PROPN
fnp-3806	4060	6	kumar	kumar	PROPN
fnp-3806	4060	7	dk	dk	PROPN
fnp-3806	4060	8	,	,	PUNCT
fnp-3806	4060	9	navalpur	navalpur	PROPN
fnp-3806	4060	10	shanmugam	shanmugam	PROPN
fnp-3806	4060	11	nk	nk	PROPN
fnp-3806	4060	12	,	,	PUNCT
fnp-3806	4061	1	et	et	PROPN
fnp-3806	4061	2	al	al	PROPN
fnp-3806	4061	3	.	.	PROPN
fnp-3806	4061	4	alzheimer	alzheimer	PROPN
fnp-3806	4061	5	’s	’s	PART
fnp-3806	4061	6	disease	disease	NOUN
fnp-3806	4061	7	-	-	PUNCT
fnp-3806	4061	8	associated	associate	VERB
fnp-3806	4061	9	β	β	NOUN
fnp-3806	4061	10	-	-	NOUN
fnp-3806	4061	11	amyloid	amyloid	NOUN
fnp-3806	4061	12	is	be	AUX
fnp-3806	4061	13	rapidly	rapidly	ADV
fnp-3806	4061	14	seeded	seed	VERB
fnp-3806	4061	15	by	by	ADP
fnp-3806	4061	16	herpesviridae	herpesviridae	NOUN
fnp-3806	4061	17	to	to	PART
fnp-3806	4061	18	protect	protect	VERB
fnp-3806	4061	19	against	against	ADP
fnp-3806	4061	20	brain	brain	NOUN
fnp-3806	4061	21	infection	infection	NOUN
fnp-3806	4061	22	.	.	PUNCT
fnp-3806	4062	1	neuron	neuron	PROPN
fnp-3806	4062	2	2018;99:56	2018;99:56	NUM
fnp-3806	4062	3	-	-	PUNCT
fnp-3806	4062	4	63.e3	63.e3	NUM
fnp-3806	4062	5	.	.	PUNCT
fnp-3806	4063	1	https://doi.org/10.1016/j.neuron.2018.06.030	https://doi.org/10.1016/j.neuron.2018.06.030	NOUN
fnp-3806	4063	2	ganz	ganz	PROPN
fnp-3806	4063	3	t	t	PROPN
fnp-3806	4063	4	,	,	PUNCT
fnp-3806	4063	5	fainstein	fainstein	NOUN
fnp-3806	4063	6	n	n	CCONJ
fnp-3806	4063	7	,	,	PUNCT
fnp-3806	4063	8	elad	elad	PROPN
fnp-3806	4063	9	a	a	X
fnp-3806	4063	10	,	,	PUNCT
fnp-3806	4063	11	et	et	PROPN
fnp-3806	4063	12	al	al	PROPN
fnp-3806	4063	13	.	.	PUNCT
fnp-3806	4064	1	microbial	microbial	ADJ
fnp-3806	4064	2	pathogens	pathogen	NOUN
fnp-3806	4064	3	induce	induce	VERB
fnp-3806	4064	4	neurodegeneration	neurodegeneration	NOUN
fnp-3806	4064	5	in	in	ADP
fnp-3806	4064	6	alzheimer	alzheimer	PROPN
fnp-3806	4064	7	's	's	PART
fnp-3806	4064	8	disease	disease	NOUN
fnp-3806	4064	9	mice	mouse	NOUN
fnp-3806	4064	10	:	:	PUNCT
fnp-3806	4064	11	protection	protection	NOUN
fnp-3806	4064	12	by	by	ADP
fnp-3806	4064	13	microglial	microglial	ADJ
fnp-3806	4064	14	regulation	regulation	NOUN
fnp-3806	4064	15	.	.	PUNCT
fnp-3806	4065	1	j	j	PROPN
fnp-3806	4065	2	neuroinflammation	neuroinflammation	PROPN
fnp-3806	4065	3	2022;19:5	2022;19:5	NOUN
fnp-3806	4065	4	.	.	PUNCT
fnp-3806	4065	5	https://doi.org/10.1186/s12974-021-02369-8	https://doi.org/10.1186/s12974-021-02369-8	NUM
fnp-3806	4066	1	phuna	phuna	NOUN
fnp-3806	4066	2	zx	zx	NUM
fnp-3806	4066	3	,	,	PUNCT
fnp-3806	4066	4	madhavan	madhavan	PROPN
fnp-3806	4066	5	p.	p.	PROPN
fnp-3806	4066	6	a	a	DET
fnp-3806	4066	7	reappraisal	reappraisal	NOUN
fnp-3806	4066	8	on	on	ADP
fnp-3806	4066	9	amyloid	amyloid	NOUN
fnp-3806	4066	10	cascade	cascade	NOUN
fnp-3806	4066	11	hypothesis	hypothesis	NOUN
fnp-3806	4066	12	:	:	PUNCT
fnp-3806	4066	13	the	the	DET
fnp-3806	4066	14	role	role	NOUN
fnp-3806	4066	15	of	of	ADP
fnp-3806	4066	16	chronic	chronic	ADJ
fnp-3806	4066	17	infection	infection	NOUN
fnp-3806	4066	18	in	in	ADP
fnp-3806	4066	19	alzheimer	alzheimer	PROPN
fnp-3806	4066	20	's	's	PART
fnp-3806	4066	21	disease	disease	NOUN
fnp-3806	4066	22	.	.	PUNCT
fnp-3806	4067	1	int	int	PROPN
fnp-3806	4067	2	j	j	PROPN
fnp-3806	4067	3	neurosci	neurosci	PROPN
fnp-3806	4067	4	2022	2022	NUM
fnp-3806	4067	5	mar	mar	PROPN
fnp-3806	4067	6	14;1	14;1	NUM
fnp-3806	4067	7	-	-	SYM
fnp-3806	4067	8	19	19	NUM
fnp-3806	4067	9	.	.	PUNCT
fnp-3806	4068	1	https://doi.org/10.1080/00207454.2022.2045290	https://doi.org/10.1080/00207454.2022.2045290	PROPN
fnp-3806	4069	1	jiang	jiang	PROPN
fnp-3806	4069	2	c	c	PROPN
fnp-3806	4069	3	,	,	PUNCT
fnp-3806	4069	4	li	li	PROPN
fnp-3806	4069	5	g	g	PROPN
fnp-3806	4069	6	,	,	PUNCT
fnp-3806	4069	7	huang	huang	PROPN
fnp-3806	4069	8	p	p	PROPN
fnp-3806	4069	9	,	,	PUNCT
fnp-3806	4069	10	et	et	PROPN
fnp-3806	4069	11	al	al	PROPN
fnp-3806	4069	12	.	.	PUNCT
fnp-3806	4070	1	the	the	DET
fnp-3806	4070	2	gut	gut	NOUN
fnp-3806	4070	3	microbiota	microbiota	NOUN
fnp-3806	4070	4	and	and	CCONJ
fnp-3806	4070	5	alzheimer	alzheimer	NOUN
fnp-3806	4070	6	's	's	PART
fnp-3806	4070	7	disease	disease	NOUN
fnp-3806	4070	8	.	.	PUNCT
fnp-3806	4071	1	j	j	PROPN
fnp-3806	4071	2	alzheimers	alzheimers	PROPN
fnp-3806	4071	3	dis	dis	PROPN
fnp-3806	4071	4	2017;58:1	2017;58:1	NUM
fnp-3806	4071	5	-	-	SYM
fnp-3806	4071	6	15	15	NUM
fnp-3806	4071	7	.	.	PUNCT
fnp-3806	4071	8	https://doi.org/10.3233/jad-161141	https://doi.org/10.3233/jad-161141	PROPN
fnp-3806	4071	9	szablewski	szablewski	PROPN
fnp-3806	4071	10	l.	l.	PROPN
fnp-3806	4071	11	human	human	ADJ
fnp-3806	4071	12	gut	gut	NOUN
fnp-3806	4071	13	microbiota	microbiota	NOUN
fnp-3806	4071	14	in	in	ADP
fnp-3806	4071	15	health	health	NOUN
fnp-3806	4071	16	and	and	CCONJ
fnp-3806	4071	17	alzheimer	alzheimer	PROPN
fnp-3806	4071	18	's	's	PART
fnp-3806	4071	19	disease	disease	NOUN
fnp-3806	4071	20	.	.	PUNCT
fnp-3806	4072	1	j	j	PROPN
fnp-3806	4072	2	alzheimers	alzheimers	PROPN
fnp-3806	4072	3	dis	dis	VERB
fnp-3806	4072	4	2018;62:549	2018;62:549	NUM
fnp-3806	4072	5	-	-	SYM
fnp-3806	4072	6	560	560	NUM
fnp-3806	4072	7	.	.	PUNCT
fnp-3806	4073	1	https://doi.org/10.3233/jad-170908	https://doi.org/10.3233/jad-170908	PROPN
fnp-3806	4073	2	megur	megur	PROPN
fnp-3806	4073	3	a	a	PRON
fnp-3806	4073	4	,	,	PUNCT
fnp-3806	4073	5	baltriukienė	baltriukienė	PROPN
fnp-3806	4073	6	d	d	PROPN
fnp-3806	4073	7	,	,	PUNCT
fnp-3806	4073	8	bukelskienė	bukelskienė	ADJ
fnp-3806	4073	9	v	v	PROPN
fnp-3806	4073	10	,	,	PUNCT
fnp-3806	4073	11	et	et	PROPN
fnp-3806	4073	12	al	al	PROPN
fnp-3806	4073	13	.	.	PUNCT
fnp-3806	4074	1	the	the	DET
fnp-3806	4074	2	microbiota	microbiota	NOUN
fnp-3806	4074	3	-	-	PUNCT
fnp-3806	4074	4	gut	gut	NOUN
fnp-3806	4074	5	-	-	PUNCT
fnp-3806	4074	6	brain	brain	NOUN
fnp-3806	4074	7	axis	axis	NOUN
fnp-3806	4074	8	and	and	CCONJ
fnp-3806	4074	9	alzheimer	alzheimer	PROPN
fnp-3806	4074	10	's	's	PART
fnp-3806	4074	11	disease	disease	NOUN
fnp-3806	4074	12	:	:	PUNCT
fnp-3806	4074	13	neuroinflammation	neuroinflammation	NOUN
fnp-3806	4074	14	is	be	AUX
fnp-3806	4074	15	to	to	PART
fnp-3806	4074	16	blame	blame	VERB
fnp-3806	4074	17	?	?	PUNCT
fnp-3806	4075	1	nutrients	nutrient	NOUN
fnp-3806	4075	2	2020;13:37	2020;13:37	NUM
fnp-3806	4075	3	.	.	PUNCT
fnp-3806	4076	1	https://doi.org/10.3390/nu13010037	https://doi.org/10.3390/nu13010037	X
fnp-3806	4076	2	pluta	pluta	ADJ
fnp-3806	4076	3	r	r	NOUN
fnp-3806	4076	4	,	,	PUNCT
fnp-3806	4076	5	ułamek	ułamek	NOUN
fnp-3806	4076	6	-	-	PUNCT
fnp-3806	4076	7	kozioł	kozioł	PROPN
fnp-3806	4076	8	m	m	PROPN
fnp-3806	4076	9	,	,	PUNCT
fnp-3806	4076	10	januszewski	januszewski	PROPN
fnp-3806	4076	11	s	s	PART
fnp-3806	4076	12	,	,	PUNCT
fnp-3806	4076	13	et	et	PROPN
fnp-3806	4076	14	al	al	PROPN
fnp-3806	4076	15	.	.	PUNCT
fnp-3806	4077	1	gut	gut	VERB
fnp-3806	4077	2	microbiota	microbiota	NOUN
fnp-3806	4077	3	and	and	CCONJ
fnp-3806	4077	4	pro	pro	ADJ
fnp-3806	4077	5	/	/	NOUN
fnp-3806	4077	6	prebiotics	prebiotic	NOUN
fnp-3806	4077	7	in	in	ADP
fnp-3806	4077	8	alzheimer	alzheimer	PROPN
fnp-3806	4077	9	's	's	PART
fnp-3806	4077	10	disease	disease	NOUN
fnp-3806	4077	11	.	.	PUNCT
fnp-3806	4078	1	aging	age	VERB
fnp-3806	4078	2	2020;12:5539	2020;12:5539	NUM
fnp-3806	4078	3	-	-	SYM
fnp-3806	4078	4	5550	5550	NUM
fnp-3806	4078	5	.	.	PUNCT
fnp-3806	4079	1	https://doi.org/10.18632/aging.102930	https://doi.org/10.18632/aging.102930	PROPN
fnp-3806	4079	2	kesika	kesika	PROPN
fnp-3806	4079	3	p	p	PROPN
fnp-3806	4079	4	,	,	PUNCT
fnp-3806	4079	5	suganthy	suganthy	ADJ
fnp-3806	4079	6	n	n	CCONJ
fnp-3806	4079	7	,	,	PUNCT
fnp-3806	4079	8	sivamaruthi	sivamaruthi	ADJ
fnp-3806	4079	9	bs	bs	PROPN
fnp-3806	4079	10	,	,	PUNCT
fnp-3806	4079	11	et	et	PROPN
fnp-3806	4079	12	al	al	PROPN
fnp-3806	4079	13	.	.	PUNCT
fnp-3806	4079	14	role	role	NOUN
fnp-3806	4079	15	of	of	ADP
fnp-3806	4079	16	gut	gut	NOUN
fnp-3806	4079	17	-	-	PUNCT
fnp-3806	4079	18	brain	brain	NOUN
fnp-3806	4079	19	axis	axis	NOUN
fnp-3806	4079	20	,	,	PUNCT
fnp-3806	4079	21	gut	gut	VERB
fnp-3806	4079	22	microbial	microbial	ADJ
fnp-3806	4079	23	composition	composition	NOUN
fnp-3806	4079	24	,	,	PUNCT
fnp-3806	4079	25	and	and	CCONJ
fnp-3806	4079	26	probiotic	probiotic	ADJ
fnp-3806	4079	27	intervention	intervention	NOUN
fnp-3806	4079	28	in	in	ADP
fnp-3806	4079	29	alzheimer	alzheimer	PROPN
fnp-3806	4079	30	's	's	PART
fnp-3806	4079	31	disease	disease	NOUN
fnp-3806	4079	32	.	.	PUNCT
fnp-3806	4080	1	life	life	NOUN
fnp-3806	4080	2	sci	sci	PROPN
fnp-3806	4080	3	2021;264:118627	2021;264:118627	NUM
fnp-3806	4080	4	.	.	PUNCT
fnp-3806	4081	1	https://doi.org/10.1016/j.lfs.2020.118627	https://doi.org/10.1016/j.lfs.2020.118627	PROPN
fnp-3806	4081	2	de	de	PROPN
fnp-3806	4081	3	la	la	PROPN
fnp-3806	4081	4	fuente	fuente	NOUN
fnp-3806	4081	5	m.	m.	NOUN
fnp-3806	4081	6	the	the	DET
fnp-3806	4081	7	role	role	NOUN
fnp-3806	4081	8	of	of	ADP
fnp-3806	4081	9	the	the	DET
fnp-3806	4081	10	microbiota	microbiota	NOUN
fnp-3806	4081	11	-	-	PUNCT
fnp-3806	4081	12	gut	gut	NOUN
fnp-3806	4081	13	-	-	PUNCT
fnp-3806	4081	14	brain	brain	NOUN
fnp-3806	4081	15	axis	axis	NOUN
fnp-3806	4081	16	in	in	ADP
fnp-3806	4081	17	the	the	DET
fnp-3806	4081	18	health	health	NOUN
fnp-3806	4081	19	and	and	CCONJ
fnp-3806	4081	20	illness	illness	NOUN
fnp-3806	4081	21	condition	condition	NOUN
fnp-3806	4081	22	:	:	PUNCT
fnp-3806	4081	23	a	a	DET
fnp-3806	4081	24	focus	focus	NOUN
fnp-3806	4081	25	on	on	ADP
fnp-3806	4081	26	alzheimer	alzheimer	PROPN
fnp-3806	4081	27	's	's	PART
fnp-3806	4081	28	disease	disease	NOUN
fnp-3806	4081	29	.	.	PUNCT
fnp-3806	4082	1	j	j	PROPN
fnp-3806	4082	2	alzheimers	alzheimers	PROPN
fnp-3806	4082	3	dis	dis	PROPN
fnp-3806	4082	4	2021;81:1345	2021;81:1345	NUM
fnp-3806	4082	5	-	-	PUNCT
fnp-3806	4082	6	1360	1360	NUM
fnp-3806	4082	7	.	.	PUNCT
fnp-3806	4083	1	https://doi.org/10.3233/jad-201587	https://doi.org/10.3233/jad-201587	PROPN
fnp-3806	4083	2	łuc	łuc	PROPN
fnp-3806	4083	3	m	m	PROPN
fnp-3806	4083	4	,	,	PUNCT
fnp-3806	4083	5	misiak	misiak	PROPN
fnp-3806	4083	6	b	b	NOUN
fnp-3806	4083	7	,	,	PUNCT
fnp-3806	4083	8	pawłowski	pawłowski	ADP
fnp-3806	4083	9	m	m	PROPN
fnp-3806	4083	10	,	,	PUNCT
fnp-3806	4083	11	et	et	PROPN
fnp-3806	4083	12	al	al	PROPN
fnp-3806	4083	13	.	.	PUNCT
fnp-3806	4084	1	gut	gut	VERB
fnp-3806	4084	2	microbiota	microbiota	NOUN
fnp-3806	4084	3	in	in	ADP
fnp-3806	4084	4	dementia	dementia	NOUN
fnp-3806	4084	5	.	.	PUNCT
fnp-3806	4085	1	critical	critical	ADJ
fnp-3806	4085	2	review	review	NOUN
fnp-3806	4085	3	of	of	ADP
fnp-3806	4085	4	novel	novel	ADJ
fnp-3806	4085	5	findings	finding	NOUN
fnp-3806	4085	6	and	and	CCONJ
fnp-3806	4085	7	their	their	PRON
fnp-3806	4085	8	potential	potential	ADJ
fnp-3806	4085	9	application	application	NOUN
fnp-3806	4085	10	.	.	PUNCT
fnp-3806	4086	1	prog	prog	PROPN
fnp-3806	4086	2	neuropsychopharmacol	neuropsychopharmacol	PROPN
fnp-3806	4086	3	.	.	PUNCT
fnp-3806	4087	1	biol	biol	PROPN
fnp-3806	4087	2	psychiatry	psychiatry	PROPN
fnp-3806	4087	3	2021;104	2021;104	PROPN
fnp-3806	4087	4	:	:	PUNCT
fnp-3806	4087	5	110039	110039	NUM
fnp-3806	4087	6	.	.	PUNCT
fnp-3806	4088	1	https://doi.org/10.1016/j.pnpbp.2020.110039	https://doi.org/10.1016/j.pnpbp.2020.110039	PROPN
fnp-3806	4088	2	aaldijk	aaldijk	PROPN
fnp-3806	4088	3	e	e	PROPN
fnp-3806	4088	4	,	,	PUNCT
fnp-3806	4088	5	vermeiren	vermeiren	PROPN
fnp-3806	4088	6	y.	y.	VERB
fnp-3806	4088	7	the	the	DET
fnp-3806	4088	8	role	role	NOUN
fnp-3806	4088	9	of	of	ADP
fnp-3806	4088	10	serotonin	serotonin	VERB
fnp-3806	4088	11	within	within	ADP
fnp-3806	4088	12	the	the	DET
fnp-3806	4088	13	microbiota	microbiota	NOUN
fnp-3806	4088	14	-	-	PUNCT
fnp-3806	4088	15	gut	gut	NOUN
fnp-3806	4088	16	-	-	PUNCT
fnp-3806	4088	17	brain	brain	NOUN
fnp-3806	4088	18	axis	axis	NOUN
fnp-3806	4088	19	in	in	ADP
fnp-3806	4088	20	the	the	DET
fnp-3806	4088	21	development	development	NOUN
fnp-3806	4088	22	of	of	ADP
fnp-3806	4088	23	alzheimer	alzheimer	PROPN
fnp-3806	4088	24	's	's	PART
fnp-3806	4088	25	disease	disease	NOUN
fnp-3806	4088	26	:	:	PUNCT
fnp-3806	4088	27	a	a	DET
fnp-3806	4088	28	narrative	narrative	NOUN
fnp-3806	4088	29	review	review	NOUN
fnp-3806	4088	30	.	.	PUNCT
fnp-3806	4089	1	ageing	age	VERB
fnp-3806	4089	2	res	re	NOUN
fnp-3806	4089	3	rev	rev	VERB
fnp-3806	4089	4	2022;3	2022;3	NOUN
fnp-3806	4089	5	:	:	PUNCT
fnp-3806	4089	6	101556	101556	NUM
fnp-3806	4089	7	.	.	PUNCT
fnp-3806	4090	1	https://doi.org/10.1016/j.arr.2021.101556	https://doi.org/10.1016/j.arr.2021.101556	X
fnp-3806	4090	2	rueda	rueda	PROPN
fnp-3806	4090	3	-	-	PUNCT
fnp-3806	4090	4	ruzafa	ruzafa	PROPN
fnp-3806	4090	5	l	l	PROPN
fnp-3806	4090	6	,	,	PUNCT
fnp-3806	4090	7	cruz	cruz	PROPN
fnp-3806	4090	8	f	f	PROPN
fnp-3806	4090	9	,	,	PUNCT
fnp-3806	4090	10	cardona	cardona	PROPN
fnp-3806	4090	11	d	d	PROPN
fnp-3806	4090	12	,	,	PUNCT
fnp-3806	4090	13	et	et	PROPN
fnp-3806	4090	14	al	al	PROPN
fnp-3806	4090	15	.	.	PROPN
fnp-3806	4091	1	opioid	opioid	ADJ
fnp-3806	4091	2	system	system	NOUN
fnp-3806	4091	3	influences	influence	VERB
fnp-3806	4091	4	gut	gut	NOUN
fnp-3806	4091	5	-	-	PUNCT
fnp-3806	4091	6	brain	brain	NOUN
fnp-3806	4091	7	axis	axis	NOUN
fnp-3806	4091	8	:	:	PUNCT
fnp-3806	4091	9	dysbiosis	dysbiosis	NOUN
fnp-3806	4091	10	and	and	CCONJ
fnp-3806	4091	11	related	related	ADJ
fnp-3806	4091	12	alterations	alteration	NOUN
fnp-3806	4091	13	.	.	PUNCT
fnp-3806	4092	1	pharmacol	pharmacol	PROPN
fnp-3806	4092	2	res	re	NOUN
fnp-3806	4092	3	2020;159:104928	2020;159:104928	NUM
fnp-3806	4092	4	.	.	PUNCT
fnp-3806	4093	1	https://doi.org/10.1016/j.phrs.2020.104928	https://doi.org/10.1016/j.phrs.2020.104928	PROPN
fnp-3806	4093	2	leaston	leaston	PROPN
fnp-3806	4093	3	j	j	PROPN
fnp-3806	4093	4	,	,	PUNCT
fnp-3806	4093	5	kulkarni	kulkarni	PROPN
fnp-3806	4093	6	p	p	PROPN
fnp-3806	4093	7	,	,	PUNCT
fnp-3806	4093	8	gharagouzloo	gharagouzloo	VERB
fnp-3806	4093	9	c	c	NOUN
fnp-3806	4093	10	,	,	PUNCT
fnp-3806	4093	11	et	et	PROPN
fnp-3806	4093	12	al	al	PROPN
fnp-3806	4093	13	.	.	PROPN
fnp-3806	4094	1	do	do	AUX
fnp-3806	4094	2	we	we	PRON
fnp-3806	4094	3	swallow	swallow	VERB
fnp-3806	4094	4	the	the	DET
fnp-3806	4094	5	waste	waste	NOUN
fnp-3806	4094	6	from	from	ADP
fnp-3806	4094	7	our	our	PRON
fnp-3806	4094	8	brain	brain	NOUN
fnp-3806	4094	9	?	?	PUNCT
fnp-3806	4095	1	front	front	ADJ
fnp-3806	4095	2	neurosci	neurosci	NOUN
fnp-3806	4095	3	2021	2021	NUM
fnp-3806	4095	4	;	;	PUNCT
fnp-3806	4095	5	15:763780	15:763780	NUM
fnp-3806	4095	6	.	.	PUNCT
fnp-3806	4096	1	https://doi.org/10.3389/fnins.2021.763780	https://doi.org/10.3389/fnins.2021.763780	PROPN
fnp-3806	4096	2	walker	walker	PROPN
fnp-3806	4096	3	lc	lc	PROPN
fnp-3806	4096	4	,	,	PUNCT
fnp-3806	4096	5	callahan	callahan	PROPN
fnp-3806	4096	6	mj	mj	PROPN
fnp-3806	4096	7	,	,	PUNCT
fnp-3806	4096	8	bian	bian	PROPN
fnp-3806	4096	9	f	f	PROPN
fnp-3806	4096	10	,	,	PUNCT
fnp-3806	4096	11	et	et	PROPN
fnp-3806	4096	12	al	al	PROPN
fnp-3806	4096	13	.	.	PROPN
fnp-3806	4096	14	exogenous	exogenous	ADJ
fnp-3806	4096	15	induction	induction	NOUN
fnp-3806	4096	16	of	of	ADP
fnp-3806	4096	17	cerebral	cerebral	ADJ
fnp-3806	4096	18	beta	beta	NOUN
fnp-3806	4096	19	-	-	PUNCT
fnp-3806	4096	20	amyloidosis	amyloidosis	NOUN
fnp-3806	4096	21	in	in	ADP
fnp-3806	4096	22	betaapp	betaapp	ADJ
fnp-3806	4096	23	-	-	PUNCT
fnp-3806	4096	24	transgenic	transgenic	NOUN
fnp-3806	4096	25	mice	mouse	NOUN
fnp-3806	4096	26	.	.	PUNCT
fnp-3806	4097	1	peptides	peptide	NOUN
fnp-3806	4097	2	2002;23	2002;23	NUM
fnp-3806	4097	3	:	:	PUNCT
fnp-3806	4097	4	1241	1241	NUM
fnp-3806	4097	5	-	-	SYM
fnp-3806	4097	6	1247	1247	NUM
fnp-3806	4097	7	.	.	PUNCT
fnp-3806	4098	1	meyer	meyer	PROPN
fnp-3806	4098	2	-	-	PUNCT
fnp-3806	4098	3	luehmann	luehmann	PROPN
fnp-3806	4098	4	m	m	PROPN
fnp-3806	4098	5	,	,	PUNCT
fnp-3806	4098	6	coomaraswamy	coomaraswamy	PROPN
fnp-3806	4098	7	j	j	NOUN
fnp-3806	4098	8	,	,	PUNCT
fnp-3806	4098	9	bolmont	bolmont	VERB
fnp-3806	4098	10	t	t	PROPN
fnp-3806	4098	11	,	,	PUNCT
fnp-3806	4098	12	et	et	PROPN
fnp-3806	4098	13	al	al	PROPN
fnp-3806	4098	14	.	.	PROPN
fnp-3806	4099	1	exogenous	exogenous	ADJ
fnp-3806	4099	2	induction	induction	NOUN
fnp-3806	4099	3	of	of	ADP
fnp-3806	4099	4	cerebral	cerebral	ADJ
fnp-3806	4099	5	b	b	NOUN
fnp-3806	4099	6	-	-	PUNCT
fnp-3806	4099	7	amyloidogenesis	amyloidogenesis	NOUN
fnp-3806	4099	8	is	be	AUX
fnp-3806	4099	9	governed	govern	VERB
fnp-3806	4099	10	by	by	ADP
fnp-3806	4099	11	agent	agent	NOUN
fnp-3806	4099	12	and	and	CCONJ
fnp-3806	4099	13	host	host	NOUN
fnp-3806	4099	14	.	.	PUNCT
fnp-3806	4100	1	science	science	NOUN
fnp-3806	4100	2	2006;313:1781	2006;313:1781	NUM
fnp-3806	4100	3	-	-	SYM
fnp-3806	4100	4	1784	1784	NUM
fnp-3806	4100	5	.	.	PUNCT
fnp-3806	4101	1	https://doi.org/10.1126/science.1131864	https://doi.org/10.1126/science.1131864	PROPN
fnp-3806	4101	2	walker	walker	PROPN
fnp-3806	4101	3	lc	lc	PROPN
fnp-3806	4101	4	,	,	PUNCT
fnp-3806	4101	5	levine	levine	PROPN
fnp-3806	4101	6	h	h	PROPN
fnp-3806	4101	7	,	,	PUNCT
fnp-3806	4101	8	mattson	mattson	PROPN
fnp-3806	4101	9	mp	mp	PROPN
fnp-3806	4101	10	,	,	PUNCT
fnp-3806	4101	11	et	et	PROPN
fnp-3806	4101	12	al	al	PROPN
fnp-3806	4101	13	.	.	PROPN
fnp-3806	4101	14	inducible	inducible	ADJ
fnp-3806	4101	15	proteopathies	proteopathie	NOUN
fnp-3806	4101	16	.	.	PUNCT
fnp-3806	4101	17	trends	trend	NOUN
fnp-3806	4101	18	neurosci	neurosci	VERB
fnp-3806	4101	19	2006;29:438	2006;29:438	NOUN
fnp-3806	4101	20	-	-	NOUN
fnp-3806	4101	21	443	443	NUM
fnp-3806	4101	22	.	.	PUNCT
fnp-3806	4102	1	https://doi.org/10.1016/j.tins.2006.06.010	https://doi.org/10.1016/j.tins.2006.06.010	PROPN
fnp-3806	4102	2	rosen	rosen	PROPN
fnp-3806	4102	3	rf	rf	PROPN
fnp-3806	4102	4	,	,	PUNCT
fnp-3806	4102	5	fritz	fritz	PROPN
fnp-3806	4102	6	jj	jj	PROPN
fnp-3806	4102	7	,	,	PUNCT
fnp-3806	4102	8	dooyema	dooyema	PROPN
fnp-3806	4102	9	j	j	PROPN
fnp-3806	4102	10	,	,	PUNCT
fnp-3806	4102	11	et	et	PROPN
fnp-3806	4102	12	al	al	PROPN
fnp-3806	4102	13	.	.	PROPN
fnp-3806	4102	14	exogenous	exogenous	ADJ
fnp-3806	4102	15	seeding	seeding	NOUN
fnp-3806	4102	16	of	of	ADP
fnp-3806	4102	17	cerebral	cerebral	ADJ
fnp-3806	4102	18	b	b	NOUN
fnp-3806	4102	19	-	-	PUNCT
fnp-3806	4102	20	amyloid	amyloid	NOUN
fnp-3806	4102	21	deposition	deposition	NOUN
fnp-3806	4102	22	in	in	ADP
fnp-3806	4102	23	bapp	bapp	VERB
fnp-3806	4102	24	-	-	PUNCT
fnp-3806	4102	25	transgenic	transgenic	NOUN
fnp-3806	4102	26	rats	rat	NOUN
fnp-3806	4102	27	.	.	PUNCT
fnp-3806	4103	1	j	j	PROPN
fnp-3806	4103	2	neurochem	neurochem	PROPN
fnp-3806	4103	3	2012;120:660	2012;120:660	PROPN
fnp-3806	4103	4	-	-	SYM
fnp-3806	4103	5	666	666	NUM
fnp-3806	4103	6	.	.	PUNCT
fnp-3806	4104	1	https://doi.org/10.1111/j.1471-4159.2011.07551.x	https://doi.org/10.1111/j.1471-4159.2011.07551.x	PROPN
fnp-3806	4104	2	morales	morales	PROPN
fnp-3806	4104	3	r	r	PROPN
fnp-3806	4104	4	,	,	PUNCT
fnp-3806	4104	5	duran	duran	NOUN
fnp-3806	4104	6	-	-	PUNCT
fnp-3806	4104	7	aniotz	aniotz	PROPN
fnp-3806	4104	8	c	c	PROPN
fnp-3806	4104	9	,	,	PUNCT
fnp-3806	4104	10	castilla	castilla	PROPN
fnp-3806	4104	11	j	j	PROPN
fnp-3806	4104	12	,	,	PUNCT
fnp-3806	4104	13	et	et	PROPN
fnp-3806	4104	14	al	al	PROPN
fnp-3806	4104	15	.	.	PROPN
fnp-3806	4104	16	de	de	PROPN
fnp-3806	4104	17	novo	novo	PROPN
fnp-3806	4104	18	induction	induction	NOUN
fnp-3806	4104	19	of	of	ADP
fnp-3806	4104	20	amyloid	amyloid	NOUN
fnp-3806	4104	21	-	-	PUNCT
fnp-3806	4104	22	b	b	NOUN
fnp-3806	4104	23	deposition	deposition	NOUN
fnp-3806	4104	24	in	in	ADP
fnp-3806	4104	25	vivo	vivo	NOUN
fnp-3806	4104	26	.	.	PUNCT
fnp-3806	4105	1	mol	mol	ADP
fnp-3806	4105	2	psychiatry	psychiatry	NOUN
fnp-3806	4105	3	2012;17:1347	2012;17:1347	PROPN
fnp-3806	4105	4	-	-	SYM
fnp-3806	4105	5	1353	1353	NUM
fnp-3806	4105	6	.	.	PUNCT
fnp-3806	4106	1	https://doi.org/10.1038/mp.2011.120	https://doi.org/10.1038/mp.2011.120	ADJ
fnp-3806	4106	2	langer	langer	PROPN
fnp-3806	4106	3	f	f	PROPN
fnp-3806	4106	4	,	,	PUNCT
fnp-3806	4106	5	eisele	eisele	PROPN
fnp-3806	4106	6	ys	ys	VERB
fnp-3806	4106	7	,	,	PUNCT
fnp-3806	4106	8	fritschi	fritschi	VERB
fnp-3806	4106	9	sk	sk	PROPN
fnp-3806	4106	10	,	,	PUNCT
fnp-3806	4106	11	et	et	PROPN
fnp-3806	4106	12	al	al	PROPN
fnp-3806	4106	13	.	.	PROPN
fnp-3806	4107	1	soluble	soluble	ADJ
fnp-3806	4107	2	aβ	aβ	NOUN
fnp-3806	4107	3	seeds	seed	NOUN
fnp-3806	4107	4	are	be	AUX
fnp-3806	4107	5	potent	potent	ADJ
fnp-3806	4107	6	inducers	inducer	NOUN
fnp-3806	4107	7	of	of	ADP
fnp-3806	4107	8	cerebral	cerebral	ADJ
fnp-3806	4107	9	b	b	NOUN
fnp-3806	4107	10	-	-	PUNCT
fnp-3806	4107	11	amyloid	amyloid	NOUN
fnp-3806	4107	12	deposition	deposition	NOUN
fnp-3806	4107	13	.	.	PUNCT
fnp-3806	4108	1	j	j	PROPN
fnp-3806	4108	2	neurosci	neurosci	PROPN
fnp-3806	4108	3	2011;31	2011;31	NUM
fnp-3806	4108	4	:	:	PUNCT
fnp-3806	4108	5	14488	14488	NUM
fnp-3806	4108	6	-	-	SYM
fnp-3806	4108	7	14495	14495	NUM
fnp-3806	4108	8	.	.	PUNCT
fnp-3806	4109	1	https://doi.org/10.1523/jneurosci.3088-11.2011	https://doi.org/10.1523/jneurosci.3088-11.2011	ADP
fnp-3806	4109	2	hamaguchi	hamaguchi	PROPN
fnp-3806	4109	3	t	t	PROPN
fnp-3806	4109	4	,	,	PUNCT
fnp-3806	4109	5	eisele	eisele	PROPN
fnp-3806	4109	6	y	y	PROPN
fnp-3806	4109	7	,	,	PUNCT
fnp-3806	4109	8	varvel	varvel	VERB
fnp-3806	4109	9	n	n	CCONJ
fnp-3806	4109	10	,	,	PUNCT
fnp-3806	4109	11	et	et	PROPN
fnp-3806	4109	12	al	al	PROPN
fnp-3806	4109	13	.	.	PUNCT
fnp-3806	4110	1	the	the	DET
fnp-3806	4110	2	presence	presence	NOUN
fnp-3806	4110	3	of	of	ADP
fnp-3806	4110	4	ab	ab	PROPN
fnp-3806	4110	5	seeds	seed	NOUN
fnp-3806	4110	6	,	,	PUNCT
fnp-3806	4110	7	and	and	CCONJ
fnp-3806	4110	8	not	not	PART
fnp-3806	4110	9	age	age	NOUN
fnp-3806	4110	10	per	per	X
fnp-3806	4110	11	se	se	X
fnp-3806	4110	12	,	,	PUNCT
fnp-3806	4110	13	is	be	AUX
fnp-3806	4110	14	critical	critical	ADJ
fnp-3806	4110	15	to	to	ADP
fnp-3806	4110	16	the	the	DET
fnp-3806	4110	17	initiation	initiation	NOUN
fnp-3806	4110	18	of	of	ADP
fnp-3806	4110	19	ab	ab	PROPN
fnp-3806	4110	20	deposition	deposition	NOUN
fnp-3806	4110	21	in	in	ADP
fnp-3806	4110	22	the	the	DET
fnp-3806	4110	23	brain	brain	NOUN
fnp-3806	4110	24	.	.	PUNCT
fnp-3806	4111	1	acta	acta	PROPN
fnp-3806	4111	2	neuropathol	neuropathol	PROPN
fnp-3806	4111	3	2012;123:31	2012;123:31	NUM
fnp-3806	4111	4	-	-	SYM
fnp-3806	4111	5	37	37	NUM
fnp-3806	4111	6	.	.	PUNCT
fnp-3806	4112	1	https://doi.org/10.1007/s00401-011-0912-1	https://doi.org/10.1007/s00401-011-0912-1	PROPN
fnp-3806	4113	1	bero	bero	PROPN
fnp-3806	4113	2	aw	aw	INTJ
fnp-3806	4113	3	,	,	PUNCT
fnp-3806	4113	4	yan	yan	PROPN
fnp-3806	4113	5	p	p	X
fnp-3806	4113	6	,	,	PUNCT
fnp-3806	4113	7	roh	roh	PROPN
fnp-3806	4113	8	jh	jh	PROPN
fnp-3806	4113	9	,	,	PUNCT
fnp-3806	4113	10	et	et	PROPN
fnp-3806	4113	11	al	al	PROPN
fnp-3806	4113	12	.	.	PUNCT
fnp-3806	4113	13	neuronal	neuronal	ADJ
fnp-3806	4113	14	activity	activity	NOUN
fnp-3806	4113	15	regulates	regulate	VERB
fnp-3806	4113	16	the	the	DET
fnp-3806	4113	17	regional	regional	ADJ
fnp-3806	4113	18	vulnerability	vulnerability	NOUN
fnp-3806	4113	19	to	to	ADP
fnp-3806	4113	20	amyloid	amyloid	NOUN
fnp-3806	4113	21	-	-	PUNCT
fnp-3806	4113	22	β	β	NOUN
fnp-3806	4113	23	deposition	deposition	NOUN
fnp-3806	4113	24	.	.	PUNCT
fnp-3806	4114	1	nat	nat	PROPN
fnp-3806	4114	2	neurosci	neurosci	PROPN
fnp-3806	4114	3	2011;14:750	2011;14:750	PROPN
fnp-3806	4114	4	-	-	SYM
fnp-3806	4114	5	756	756	NUM
fnp-3806	4114	6	.	.	PUNCT
fnp-3806	4115	1	https://doi.org/10.1038/nn.2801	https://doi.org/10.1038/nn.2801	PROPN
fnp-3806	4115	2	eisele	eisele	NOUN
fnp-3806	4115	3	ys	ys	VERB
fnp-3806	4115	4	,	,	PUNCT
fnp-3806	4115	5	obermüller	obermüller	ADJ
fnp-3806	4115	6	u	u	NOUN
fnp-3806	4115	7	,	,	PUNCT
fnp-3806	4115	8	heilbronner	heilbronner	NOUN
fnp-3806	4115	9	g	g	PROPN
fnp-3806	4115	10	et	et	PROPN
fnp-3806	4115	11	al	al	PROPN
fnp-3806	4115	12	.	.	PROPN
fnp-3806	4115	13	peripherally	peripherally	ADV
fnp-3806	4115	14	applied	apply	VERB
fnp-3806	4115	15	abeta	abeta	ADV
fnp-3806	4115	16	-	-	PUNCT
fnp-3806	4115	17	containing	contain	VERB
fnp-3806	4115	18	inoculates	inoculate	NOUN
fnp-3806	4115	19	induce	induce	VERB
fnp-3806	4115	20	cerebral	cerebral	ADJ
fnp-3806	4115	21	beta	beta	NOUN
fnp-3806	4115	22	-	-	PUNCT
fnp-3806	4115	23	amyloidosis	amyloidosis	NOUN
fnp-3806	4115	24	.	.	PUNCT
fnp-3806	4116	1	science	science	NOUN
fnp-3806	4116	2	2010;330:980	2010;330:980	NUM
fnp-3806	4116	3	-	-	SYM
fnp-3806	4116	4	982	982	NUM
fnp-3806	4116	5	.	.	PUNCT
fnp-3806	4117	1	https://doi.org/10.1126/science.1194516	https://doi.org/10.1126/science.1194516	VERB
fnp-3806	4117	2	forny	forny	PROPN
fnp-3806	4117	3	-	-	PUNCT
fnp-3806	4117	4	germano	germano	PROPN
fnp-3806	4117	5	l	l	PROPN
fnp-3806	4117	6	,	,	PUNCT
fnp-3806	4117	7	lyra	lyra	PROPN
fnp-3806	4117	8	de	de	PROPN
fnp-3806	4117	9	silva	silva	PROPN
fnp-3806	4117	10	nm	nm	PROPN
fnp-3806	4117	11	,	,	PUNCT
fnp-3806	4117	12	batista	batista	PROPN
fnp-3806	4117	13	af	af	PROPN
fnp-3806	4117	14	,	,	PUNCT
fnp-3806	4117	15	et	et	PROPN
fnp-3806	4117	16	al	al	PROPN
fnp-3806	4117	17	.	.	PROPN
fnp-3806	4117	18	alzheimer	alzheimer	PROPN
fnp-3806	4117	19	's	's	PART
fnp-3806	4117	20	disease	disease	NOUN
fnp-3806	4117	21	-	-	PUNCT
fnp-3806	4117	22	like	like	ADJ
fnp-3806	4117	23	pathology	pathology	NOUN
fnp-3806	4117	24	induced	induce	VERB
fnp-3806	4117	25	by	by	ADP
fnp-3806	4117	26	amyloid	amyloid	NOUN
fnp-3806	4117	27	-	-	PUNCT
fnp-3806	4117	28	beta	beta	NOUN
fnp-3806	4117	29	oligomers	oligomer	NOUN
fnp-3806	4117	30	in	in	ADP
fnp-3806	4117	31	nonhuman	nonhuman	ADJ
fnp-3806	4117	32	primates	primate	NOUN
fnp-3806	4117	33	.	.	PUNCT
fnp-3806	4118	1	j	j	PROPN
fnp-3806	4118	2	neurosci	neurosci	PROPN
fnp-3806	4118	3	2014;34:13629	2014;34:13629	PROPN
fnp-3806	4118	4	-	-	SYM
fnp-3806	4118	5	13643	13643	NUM
fnp-3806	4118	6	.	.	PUNCT
fnp-3806	4119	1	https://doi.org/10.1523/jneurosci.1353-14.2014	https://doi.org/10.1523/jneurosci.1353-14.2014	PROPN
fnp-3806	4119	2	lauwers	lauwer	NOUN
fnp-3806	4119	3	e	e	NOUN
fnp-3806	4119	4	,	,	PUNCT
fnp-3806	4119	5	lalli	lalli	VERB
fnp-3806	4119	6	g	g	PROPN
fnp-3806	4119	7	,	,	PUNCT
fnp-3806	4119	8	brandner	brandner	NOUN
fnp-3806	4119	9	s	s	PROPN
fnp-3806	4119	10	,	,	PUNCT
fnp-3806	4119	11	et	et	PROPN
fnp-3806	4119	12	al	al	PROPN
fnp-3806	4119	13	.	.	PROPN
fnp-3806	4120	1	potential	potential	ADJ
fnp-3806	4120	2	human	human	ADJ
fnp-3806	4120	3	transmission	transmission	NOUN
fnp-3806	4120	4	of	of	ADP
fnp-3806	4120	5	amyloid	amyloid	NOUN
fnp-3806	4120	6	-	-	PUNCT
fnp-3806	4120	7	beta	beta	NOUN
fnp-3806	4120	8	pathology	pathology	NOUN
fnp-3806	4120	9	:	:	PUNCT
fnp-3806	4120	10	surveillance	surveillance	NOUN
fnp-3806	4120	11	and	and	CCONJ
fnp-3806	4120	12	risks	risk	NOUN
fnp-3806	4120	13	.	.	PUNCT
fnp-3806	4121	1	lancet	lancet	PROPN
fnp-3806	4121	2	neurol	neurol	PROPN
fnp-3806	4121	3	2020;19:872	2020;19:872	PROPN
fnp-3806	4121	4	-	-	PUNCT
fnp-3806	4121	5	878	878	NUM
fnp-3806	4121	6	.	.	PUNCT
fnp-3806	4122	1	https://doi.org/10.1016/s1474-4422(20)30238-6	https://doi.org/10.1016/s1474-4422(20)30238-6	PROPN
fnp-3806	4122	2	pooler	pooler	PROPN
fnp-3806	4122	3	am	am	PROPN
fnp-3806	4122	4	,	,	PUNCT
fnp-3806	4122	5	phillips	phillips	PROPN
fnp-3806	4122	6	ec	ec	PROPN
fnp-3806	4122	7	,	,	PUNCT
fnp-3806	4122	8	lau	lau	PROPN
fnp-3806	4122	9	dhw	dhw	PROPN
fnp-3806	4122	10	,	,	PUNCT
fnp-3806	4122	11	et	et	PROPN
fnp-3806	4122	12	al	al	PROPN
fnp-3806	4122	13	.	.	PUNCT
fnp-3806	4122	14	physiological	physiological	ADJ
fnp-3806	4122	15	release	release	NOUN
fnp-3806	4122	16	of	of	ADP
fnp-3806	4122	17	endogenous	endogenous	ADJ
fnp-3806	4122	18	tau	tau	PROPN
fnp-3806	4122	19	is	be	AUX
fnp-3806	4122	20	stimulated	stimulate	VERB
fnp-3806	4122	21	by	by	ADP
fnp-3806	4122	22	neuronal	neuronal	ADJ
fnp-3806	4122	23	activity	activity	NOUN
fnp-3806	4122	24	.	.	PUNCT
fnp-3806	4123	1	embo	embo	PROPN
fnp-3806	4123	2	rep	rep	PROPN
fnp-3806	4123	3	2013;14:389	2013;14:389	NUM
fnp-3806	4123	4	-	-	SYM
fnp-3806	4123	5	394	394	NUM
fnp-3806	4123	6	.	.	PUNCT
fnp-3806	4124	1	https://doi.org/10.1038/embor.2013.15	https://doi.org/10.1038/embor.2013.15	PROPN
fnp-3806	4124	2	yamada	yamada	PROPN
fnp-3806	4124	3	k	k	PROPN
fnp-3806	4124	4	,	,	PUNCT
fnp-3806	4124	5	holth	holth	PROPN
fnp-3806	4124	6	jk	jk	PROPN
fnp-3806	4124	7	,	,	PUNCT
fnp-3806	4124	8	liao	liao	PROPN
fnp-3806	4124	9	f	f	PROPN
fnp-3806	4124	10	,	,	PUNCT
fnp-3806	4124	11	et	et	PROPN
fnp-3806	4124	12	al	al	PROPN
fnp-3806	4124	13	.	.	PUNCT
fnp-3806	4124	14	neuronal	neuronal	ADJ
fnp-3806	4124	15	activity	activity	NOUN
fnp-3806	4124	16	regulates	regulate	VERB
fnp-3806	4124	17	extracellular	extracellular	ADJ
fnp-3806	4124	18	tau	tau	PROPN
fnp-3806	4124	19	in	in	ADP
fnp-3806	4124	20	vivo	vivo	NOUN
fnp-3806	4124	21	.	.	PUNCT
fnp-3806	4125	1	j	j	PROPN
fnp-3806	4125	2	exp	exp	NOUN
fnp-3806	4125	3	med	med	PROPN
fnp-3806	4125	4	2014	2014	NUM
fnp-3806	4125	5	;	;	PUNCT
fnp-3806	4125	6	211:387	211:387	NOUN
fnp-3806	4125	7	-	-	PUNCT
fnp-3806	4125	8	393	393	NUM
fnp-3806	4125	9	.	.	PUNCT
fnp-3806	4126	1	https://doi.org/10.1084/jem.2013168	https://doi.org/10.1084/jem.2013168	PROPN
fnp-3806	4126	2	wu	wu	PROPN
fnp-3806	4126	3	jw	jw	PROPN
fnp-3806	4126	4	,	,	PUNCT
fnp-3806	4126	5	hussaini	hussaini	PROPN
fnp-3806	4126	6	sa	sa	PROPN
fnp-3806	4126	7	,	,	PUNCT
fnp-3806	4126	8	bastille	bastille	PROPN
fnp-3806	4127	1	i	i	PROPN
fnp-3806	4127	2	m	m	PROPN
fnp-3806	4127	3	,	,	PUNCT
fnp-3806	4127	4	et	et	PROPN
fnp-3806	4127	5	al	al	PROPN
fnp-3806	4127	6	.	.	PUNCT
fnp-3806	4127	7	neuronal	neuronal	ADJ
fnp-3806	4127	8	activity	activity	NOUN
fnp-3806	4127	9	enhances	enhance	VERB
fnp-3806	4127	10	tau	tau	NOUN
fnp-3806	4127	11	propagation	propagation	NOUN
fnp-3806	4127	12	and	and	CCONJ
fnp-3806	4127	13	tau	tau	PROPN
fnp-3806	4127	14	pathology	pathology	NOUN
fnp-3806	4127	15	in	in	ADP
fnp-3806	4127	16	vivo	vivo	NOUN
fnp-3806	4127	17	.	.	PUNCT
fnp-3806	4128	1	nat	nat	PROPN
fnp-3806	4128	2	neurosci	neurosci	PROPN
fnp-3806	4128	3	2016;19:1085	2016;19:1085	NUM
fnp-3806	4128	4	-	-	SYM
fnp-3806	4128	5	1092	1092	NUM
fnp-3806	4128	6	.	.	PUNCT
fnp-3806	4129	1	https://doi.org/10.1038/nn.4328	https://doi.org/10.1038/nn.4328	PROPN
fnp-3806	4129	2	schultz	schultz	PROPN
fnp-3806	4129	3	mk	mk	PROPN
fnp-3806	4129	4	,	,	PUNCT
fnp-3806	4129	5	gentzel	gentzel	ADJ
fnp-3806	4129	6	r	r	NOUN
fnp-3806	4129	7	,	,	PUNCT
fnp-3806	4129	8	usenovic	usenovic	PROPN
fnp-3806	4129	9	m	m	PROPN
fnp-3806	4129	10	,	,	PUNCT
fnp-3806	4129	11	et	et	PROPN
fnp-3806	4129	12	al	al	PROPN
fnp-3806	4129	13	.	.	PROPN
fnp-3806	4130	1	pharmacogenetic	pharmacogenetic	ADJ
fnp-3806	4130	2	neuronal	neuronal	ADJ
fnp-3806	4130	3	stimulation	stimulation	NOUN
fnp-3806	4130	4	increases	increase	VERB
fnp-3806	4130	5	human	human	PROPN
fnp-3806	4130	6	tau	tau	PROPN
fnp-3806	4130	7	pathology	pathology	NOUN
fnp-3806	4130	8	and	and	CCONJ
fnp-3806	4130	9	trans	trans	ADJ
fnp-3806	4130	10	-	-	ADJ
fnp-3806	4130	11	synaptic	synaptic	ADJ
fnp-3806	4130	12	spread	spread	NOUN
fnp-3806	4130	13	of	of	ADP
fnp-3806	4130	14	tau	tau	PROPN
fnp-3806	4130	15	to	to	ADP
fnp-3806	4130	16	distal	distal	ADJ
fnp-3806	4130	17	brain	brain	NOUN
fnp-3806	4130	18	regions	region	NOUN
fnp-3806	4130	19	in	in	ADP
fnp-3806	4130	20	mice	mouse	NOUN
fnp-3806	4130	21	.	.	PUNCT
fnp-3806	4131	1	neurobiol	neurobiol	PROPN
fnp-3806	4131	2	dis	dis	PROPN
fnp-3806	4131	3	2018;118:161	2018;118:161	NUM
fnp-3806	4131	4	-	-	NOUN
fnp-3806	4131	5	176	176	NUM
fnp-3806	4131	6	.	.	PUNCT
fnp-3806	4132	1	https://doi.org/10.1016/j.nbd.2018.07.003	https://doi.org/10.1016/j.nbd.2018.07.003	PROPN
fnp-3806	4132	2	saman	saman	PROPN
fnp-3806	4132	3	s	s	PROPN
fnp-3806	4132	4	,	,	PUNCT
fnp-3806	4132	5	kim	kim	PROPN
fnp-3806	4132	6	wh	wh	PROPN
fnp-3806	4132	7	,	,	PUNCT
fnp-3806	4132	8	raya	raya	PROPN
fnp-3806	4132	9	m	m	PROPN
fnp-3806	4132	10	,	,	PUNCT
fnp-3806	4132	11	et	et	PROPN
fnp-3806	4132	12	al	al	PROPN
fnp-3806	4132	13	.	.	PROPN
fnp-3806	4132	14	exosome	exosome	PROPN
fnp-3806	4132	15	-	-	PUNCT
fnp-3806	4132	16	associated	associate	VERB
fnp-3806	4132	17	tau	tau	PROPN
fnp-3806	4132	18	is	be	AUX
fnp-3806	4132	19	secreted	secrete	VERB
fnp-3806	4132	20	in	in	ADP
fnp-3806	4132	21	tauopathy	tauopathy	ADJ
fnp-3806	4132	22	models	model	NOUN
fnp-3806	4132	23	and	and	CCONJ
fnp-3806	4132	24	is	be	AUX
fnp-3806	4132	25	selectively	selectively	ADV
fnp-3806	4132	26	phosphorylated	phosphorylate	VERB
fnp-3806	4132	27	in	in	ADP
fnp-3806	4132	28	cerebrospinal	cerebrospinal	ADJ
fnp-3806	4132	29	fluid	fluid	NOUN
fnp-3806	4132	30	in	in	ADP
fnp-3806	4132	31	early	early	ADJ
fnp-3806	4132	32	alzheimer	alzheimer	PROPN
fnp-3806	4132	33	disease	disease	NOUN
fnp-3806	4132	34	.	.	PUNCT
fnp-3806	4133	1	j	j	PROPN
fnp-3806	4133	2	biol	biol	PROPN
fnp-3806	4133	3	chem	chem	NOUN
fnp-3806	4133	4	2012;287:3842	2012;287:3842	NUM
fnp-3806	4133	5	-	-	SYM
fnp-3806	4133	6	3849	3849	NUM
fnp-3806	4133	7	.	.	PUNCT
fnp-3806	4134	1	https://doi.org/10.1074/jbc.m111.277061	https://doi.org/10.1074/jbc.m111.277061	PROPN
fnp-3806	4134	2	takeda	takeda	NOUN
fnp-3806	4134	3	s	s	PROPN
fnp-3806	4134	4	,	,	PUNCT
fnp-3806	4134	5	wegmann	wegmann	PROPN
fnp-3806	4134	6	s	s	PROPN
fnp-3806	4134	7	,	,	PUNCT
fnp-3806	4134	8	cho	cho	PROPN
fnp-3806	4134	9	h	h	PROPN
fnp-3806	4134	10	,	,	PUNCT
fnp-3806	4134	11	et	et	PROPN
fnp-3806	4134	12	al	al	PROPN
fnp-3806	4134	13	.	.	PUNCT
fnp-3806	4134	14	neuronal	neuronal	ADJ
fnp-3806	4134	15	uptake	uptake	NOUN
fnp-3806	4134	16	and	and	CCONJ
fnp-3806	4134	17	propagation	propagation	NOUN
fnp-3806	4134	18	of	of	ADP
fnp-3806	4134	19	a	a	DET
fnp-3806	4134	20	rare	rare	ADJ
fnp-3806	4134	21	phosphorylated	phosphorylate	VERB
fnp-3806	4134	22	high	high	ADJ
fnp-3806	4134	23	-	-	PUNCT
fnp-3806	4134	24	molecular	molecular	ADJ
fnp-3806	4134	25	-	-	PUNCT
fnp-3806	4134	26	weight	weight	NOUN
fnp-3806	4134	27	tau	tau	NOUN
fnp-3806	4134	28	derived	derive	VERB
fnp-3806	4134	29	from	from	ADP
fnp-3806	4134	30	alzheimer	alzheimer	PROPN
fnp-3806	4134	31	’s	’s	PART
fnp-3806	4134	32	disease	disease	NOUN
fnp-3806	4134	33	brain	brain	NOUN
fnp-3806	4134	34	.	.	PUNCT
fnp-3806	4135	1	nat	nat	PROPN
fnp-3806	4135	2	commun	commun	PROPN
fnp-3806	4135	3	2015;6	2015;6	NUM
fnp-3806	4135	4	:	:	PUNCT
fnp-3806	4135	5	8490	8490	NUM
fnp-3806	4135	6	.	.	PUNCT
fnp-3806	4136	1	https://doi.org/10.1038/ncomms9490	https://doi.org/10.1038/ncomms9490	ADJ
fnp-3806	4136	2	mudner	mudner	ADV
fnp-3806	4136	3	a	a	NOUN
fnp-3806	4136	4	,	,	PUNCT
fnp-3806	4136	5	colin	colin	PROPN
fnp-3806	4136	6	m	m	PROPN
fnp-3806	4136	7	,	,	PUNCT
fnp-3806	4136	8	dujardin	dujardin	PROPN
fnp-3806	4136	9	s	s	PROPN
fnp-3806	4136	10	,	,	PUNCT
fnp-3806	4136	11	et	et	PROPN
fnp-3806	4136	12	al	al	PROPN
fnp-3806	4136	13	.	.	PUNCT
fnp-3806	4137	1	what	what	PRON
fnp-3806	4137	2	is	be	AUX
fnp-3806	4137	3	the	the	DET
fnp-3806	4137	4	evidence	evidence	NOUN
fnp-3806	4137	5	that	that	PRON
fnp-3806	4137	6	tau	tau	PROPN
fnp-3806	4137	7	pathology	pathology	NOUN
fnp-3806	4137	8	spreads	spread	VERB
fnp-3806	4137	9	through	through	ADP
fnp-3806	4137	10	prion	prion	NOUN
fnp-3806	4137	11	-	-	PUNCT
fnp-3806	4137	12	like	like	ADJ
fnp-3806	4137	13	propagation	propagation	NOUN
fnp-3806	4137	14	?	?	PUNCT
fnp-3806	4138	1	acta	acta	PROPN
fnp-3806	4138	2	neuropathol	neuropathol	PROPN
fnp-3806	4138	3	commun	commun	PROPN
fnp-3806	4138	4	2017	2017	NUM
fnp-3806	4138	5	;	;	PUNCT
fnp-3806	4138	6	5:99	5:99	NUM
fnp-3806	4138	7	.	.	NOUN
fnp-3806	4138	8	https://doi.org/10.1186/s40478-017-0488-7	https://doi.org/10.1186/s40478-017-0488-7	NUM
fnp-3806	4139	1	dujardin	dujardin	PROPN
fnp-3806	4139	2	s	s	PROPN
fnp-3806	4139	3	,	,	PUNCT
fnp-3806	4139	4	hyman	hyman	PROPN
fnp-3806	4139	5	bt	bt	PROPN
fnp-3806	4139	6	.	.	PUNCT
fnp-3806	4140	1	tau	tau	PROPN
fnp-3806	4140	2	prion	prion	NOUN
fnp-3806	4140	3	-	-	PUNCT
fnp-3806	4140	4	like	like	ADJ
fnp-3806	4140	5	propagation	propagation	NOUN
fnp-3806	4140	6	:	:	PUNCT
fnp-3806	4140	7	state	state	NOUN
fnp-3806	4140	8	of	of	ADP
fnp-3806	4140	9	the	the	DET
fnp-3806	4140	10	art	art	NOUN
fnp-3806	4140	11	and	and	CCONJ
fnp-3806	4140	12	current	current	ADJ
fnp-3806	4140	13	challenges	challenge	NOUN
fnp-3806	4140	14	.	.	PUNCT
fnp-3806	4141	1	adv	adv	PROPN
fnp-3806	4141	2	exp	exp	NOUN
fnp-3806	4141	3	med	med	ADJ
fnp-3806	4141	4	biol	biol	NOUN
fnp-3806	4141	5	2019;1184:305	2019;1184:305	PROPN
fnp-3806	4141	6	-	-	PUNCT
fnp-3806	4141	7	325	325	NUM
fnp-3806	4141	8	.	.	PUNCT
fnp-3806	4142	1	https://doi.org/10.1007/978-981-32-9358-8_23	https://doi.org/10.1007/978-981-32-9358-8_23	PRON
fnp-3806	4142	2	goedert	goedert	PROPN
fnp-3806	4142	3	m.	m.	PROPN
fnp-3806	4142	4	tau	tau	PROPN
fnp-3806	4142	5	proteinopathies	proteinopathie	NOUN
fnp-3806	4142	6	and	and	CCONJ
fnp-3806	4142	7	the	the	DET
fnp-3806	4142	8	prion	prion	NOUN
fnp-3806	4142	9	concept	concept	NOUN
fnp-3806	4142	10	.	.	PUNCT
fnp-3806	4143	1	prog	prog	NOUN
fnp-3806	4143	2	mol	mol	ADP
fnp-3806	4143	3	biol	biol	PROPN
fnp-3806	4143	4	transl	transl	PROPN
fnp-3806	4143	5	sci	sci	PROPN
fnp-3806	4143	6	2020;175	2020;175	PROPN
fnp-3806	4143	7	:	:	PUNCT
fnp-3806	4144	1	239	239	NUM
fnp-3806	4144	2	-	-	SYM
fnp-3806	4144	3	259	259	NUM
fnp-3806	4144	4	.	.	PUNCT
fnp-3806	4144	5	https://doi.org/10.1016/bs.pmbts.2020.08.003	https://doi.org/10.1016/bs.pmbts.2020.08.003	X
fnp-3806	4145	1	peng	peng	PROPN
fnp-3806	4145	2	c	c	PROPN
fnp-3806	4145	3	,	,	PUNCT
fnp-3806	4145	4	trojanowski	trojanowski	PROPN
fnp-3806	4145	5	jq	jq	PROPN
fnp-3806	4145	6	,	,	PUNCT
fnp-3806	4145	7	lee	lee	PROPN
fnp-3806	4145	8	vmy	vmy	PROPN
fnp-3806	4145	9	.	.	PUNCT
fnp-3806	4146	1	protein	protein	NOUN
fnp-3806	4146	2	transmission	transmission	NOUN
fnp-3806	4146	3	in	in	ADP
fnp-3806	4146	4	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4146	5	disease	disease	NOUN
fnp-3806	4146	6	.	.	PUNCT
fnp-3806	4147	1	nat	nat	PROPN
fnp-3806	4147	2	rev	rev	VERB
fnp-3806	4147	3	neurol	neurol	PROPN
fnp-3806	4147	4	2020;16:199	2020;16:199	PROPN
fnp-3806	4147	5	-	-	PUNCT
fnp-3806	4147	6	212	212	NUM
fnp-3806	4147	7	.	.	PUNCT
fnp-3806	4148	1	https://doi.org/10.1038/s41582-020-0333-7	https://doi.org/10.1038/s41582-020-0333-7	PROPN
fnp-3806	4148	2	de	de	X
fnp-3806	4148	3	calignon	calignon	PROPN
fnp-3806	4148	4	a	a	PROPN
fnp-3806	4148	5	,	,	PUNCT
fnp-3806	4148	6	polydoro	polydoro	PROPN
fnp-3806	4148	7	m	m	PROPN
fnp-3806	4148	8	,	,	PUNCT
fnp-3806	4148	9	suárez	suárez	NOUN
fnp-3806	4148	10	-	-	PUNCT
fnp-3806	4148	11	calvet	calvet	NOUN
fnp-3806	4148	12	m	m	PROPN
fnp-3806	4148	13	,	,	PUNCT
fnp-3806	4148	14	et	et	PROPN
fnp-3806	4148	15	al	al	PROPN
fnp-3806	4148	16	.	.	PROPN
fnp-3806	4148	17	propagation	propagation	NOUN
fnp-3806	4148	18	of	of	ADP
fnp-3806	4148	19	tau	tau	PROPN
fnp-3806	4148	20	pathology	pathology	NOUN
fnp-3806	4148	21	in	in	ADP
fnp-3806	4148	22	a	a	DET
fnp-3806	4148	23	model	model	NOUN
fnp-3806	4148	24	of	of	ADP
fnp-3806	4148	25	early	early	ADJ
fnp-3806	4148	26	alzheimer	alzheimer	PROPN
fnp-3806	4148	27	's	's	PART
fnp-3806	4148	28	disease	disease	NOUN
fnp-3806	4148	29	.	.	PUNCT
fnp-3806	4149	1	neuron	neuron	PROPN
fnp-3806	4150	1	2012;73:685	2012;73:685	PROPN
fnp-3806	4150	2	-	-	SYM
fnp-3806	4150	3	697	697	NUM
fnp-3806	4150	4	.	.	PUNCT
fnp-3806	4151	1	https://doi.org/10.1016/j.neuron.2011.11.033	https://doi.org/10.1016/j.neuron.2011.11.033	PROPN
fnp-3806	4151	2	liu	liu	PROPN
fnp-3806	4151	3	l	l	PROPN
fnp-3806	4151	4	,	,	PUNCT
fnp-3806	4151	5	drouet	drouet	VERB
fnp-3806	4151	6	v	v	ADP
fnp-3806	4151	7	,	,	PUNCT
fnp-3806	4151	8	wu	wu	PROPN
fnp-3806	4151	9	jw	jw	PROPN
fnp-3806	4151	10	,	,	PUNCT
fnp-3806	4151	11	et	et	PROPN
fnp-3806	4151	12	al	al	PROPN
fnp-3806	4151	13	.	.	PUNCT
fnp-3806	4152	1	trans	trans	ADJ
fnp-3806	4152	2	-	-	ADJ
fnp-3806	4152	3	synaptic	synaptic	ADJ
fnp-3806	4152	4	spread	spread	NOUN
fnp-3806	4152	5	of	of	ADP
fnp-3806	4152	6	tau	tau	PROPN
fnp-3806	4152	7	pathology	pathology	NOUN
fnp-3806	4152	8	in	in	ADP
fnp-3806	4152	9	vivo	vivo	NOUN
fnp-3806	4152	10	.	.	PUNCT
fnp-3806	4153	1	plos	plos	PROPN
fnp-3806	4153	2	one	one	NUM
fnp-3806	4153	3	2012	2012	NUM
fnp-3806	4153	4	;	;	PUNCT
fnp-3806	4153	5	7	7	NUM
fnp-3806	4153	6	:	:	PUNCT
fnp-3806	4153	7	e31302	e31302	PROPN
fnp-3806	4153	8	.	.	PUNCT
fnp-3806	4154	1	https://doi.org/10.1371/journal.pone.0031302	https://doi.org/10.1371/journal.pone.0031302	PROPN
fnp-3806	4154	2	dujardin	dujardin	PROPN
fnp-3806	4154	3	s	s	PROPN
fnp-3806	4154	4	,	,	PUNCT
fnp-3806	4154	5	lécolle	lécolle	VERB
fnp-3806	4154	6	k	k	NOUN
fnp-3806	4154	7	,	,	PUNCT
fnp-3806	4154	8	caillierez	caillierez	NOUN
fnp-3806	4154	9	r	r	PROPN
fnp-3806	4154	10	,	,	PUNCT
fnp-3806	4154	11	et	et	PROPN
fnp-3806	4154	12	al	al	PROPN
fnp-3806	4154	13	.	.	PROPN
fnp-3806	4154	14	neuron	neuron	PROPN
fnp-3806	4154	15	-	-	PUNCT
fnp-3806	4154	16	to	to	ADP
fnp-3806	4154	17	-	-	PUNCT
fnp-3806	4154	18	neuron	neuron	VERB
fnp-3806	4154	19	wild	wild	ADJ
fnp-3806	4154	20	-	-	PUNCT
fnp-3806	4154	21	type	type	NOUN
fnp-3806	4154	22	tau	tau	NOUN
fnp-3806	4154	23	protein	protein	NOUN
fnp-3806	4154	24	transfer	transfer	NOUN
fnp-3806	4154	25	through	through	ADP
fnp-3806	4154	26	a	a	DET
fnp-3806	4154	27	trans	trans	ADJ
fnp-3806	4154	28	-	-	ADJ
fnp-3806	4154	29	synaptic	synaptic	ADJ
fnp-3806	4154	30	mechanism	mechanism	NOUN
fnp-3806	4154	31	:	:	PUNCT
fnp-3806	4154	32	relevance	relevance	NOUN
fnp-3806	4154	33	to	to	ADP
fnp-3806	4154	34	sporadic	sporadic	ADJ
fnp-3806	4154	35	tauopathies	tauopathie	NOUN
fnp-3806	4154	36	.	.	PUNCT
fnp-3806	4155	1	acta	acta	PROPN
fnp-3806	4155	2	neuropathol	neuropathol	PROPN
fnp-3806	4155	3	commun	commun	PROPN
fnp-3806	4155	4	2014	2014	NUM
fnp-3806	4155	5	;	;	PUNCT
fnp-3806	4155	6	2:14	2:14	NUM
fnp-3806	4155	7	.	.	PUNCT
fnp-3806	4156	1	https://doi.org/10.1186/2051-5960-2-14	https://doi.org/10.1186/2051-5960-2-14	PROPN
fnp-3806	4156	2	fauré	fauré	PROPN
fnp-3806	4156	3	j	j	PROPN
fnp-3806	4156	4	,	,	PUNCT
fnp-3806	4156	5	lachenal	lachenal	ADJ
fnp-3806	4156	6	g	g	NOUN
fnp-3806	4156	7	,	,	PUNCT
fnp-3806	4156	8	court	court	NOUN
fnp-3806	4156	9	m	m	PROPN
fnp-3806	4156	10	,	,	PUNCT
fnp-3806	4156	11	et	et	PROPN
fnp-3806	4156	12	al	al	PROPN
fnp-3806	4156	13	.	.	PROPN
fnp-3806	4156	14	exosomes	exosome	NOUN
fnp-3806	4156	15	are	be	AUX
fnp-3806	4156	16	released	release	VERB
fnp-3806	4156	17	by	by	ADP
fnp-3806	4156	18	cultured	cultured	ADJ
fnp-3806	4156	19	cortical	cortical	ADJ
fnp-3806	4156	20	neurones	neurone	NOUN
fnp-3806	4156	21	.	.	PUNCT
fnp-3806	4157	1	mol	mol	ADP
fnp-3806	4157	2	cell	cell	NOUN
fnp-3806	4157	3	neurosci	neurosci	NOUN
fnp-3806	4157	4	2006;31	2006;31	NUM
fnp-3806	4157	5	,	,	PUNCT
fnp-3806	4157	6	642	642	NUM
fnp-3806	4157	7	-	-	SYM
fnp-3806	4157	8	648	648	NUM
fnp-3806	4157	9	.	.	PUNCT
fnp-3806	4158	1	https://doi.org/10.1016/j.mcn.2005.12.003	https://doi.org/10.1016/j.mcn.2005.12.003	PROPN
fnp-3806	4158	2	smalheiser	smalheiser	PROPN
fnp-3806	4158	3	nr	nr	PROPN
fnp-3806	4158	4	.	.	PROPN
fnp-3806	4158	5	exosomal	exosomal	ADJ
fnp-3806	4158	6	transfer	transfer	NOUN
fnp-3806	4158	7	of	of	ADP
fnp-3806	4158	8	proteins	protein	NOUN
fnp-3806	4158	9	and	and	CCONJ
fnp-3806	4158	10	rnas	rna	NOUN
fnp-3806	4158	11	at	at	ADP
fnp-3806	4158	12	synapses	synapsis	NOUN
fnp-3806	4158	13	in	in	ADP
fnp-3806	4158	14	the	the	DET
fnp-3806	4158	15	nervous	nervous	ADJ
fnp-3806	4158	16	system	system	NOUN
fnp-3806	4158	17	.	.	PUNCT
fnp-3806	4159	1	biol	biol	PROPN
fnp-3806	4159	2	direct	direct	ADJ
fnp-3806	4159	3	2007;2:35	2007;2:35	NOUN
fnp-3806	4159	4	.	.	PUNCT
fnp-3806	4160	1	https://doi.org/10.1186/1745-6150-2-35	https://doi.org/10.1186/1745-6150-2-35	ADV
fnp-3806	4160	2	frost	frost	PROPN
fnp-3806	4160	3	b	b	PROPN
fnp-3806	4160	4	,	,	PUNCT
fnp-3806	4160	5	jacks	jack	NOUN
fnp-3806	4160	6	rl	rl	PROPN
fnp-3806	4160	7	,	,	PUNCT
fnp-3806	4160	8	diamond	diamond	PROPN
fnp-3806	4160	9	mi	mi	PROPN
fnp-3806	4160	10	.	.	PROPN
fnp-3806	4160	11	small	small	PROPN
fnp-3806	4160	12	misfolded	misfolde	VERB
fnp-3806	4161	1	tau	tau	PROPN
fnp-3806	4161	2	species	specie	NOUN
fnp-3806	4161	3	are	be	AUX
fnp-3806	4161	4	internalized	internalize	VERB
fnp-3806	4161	5	via	via	ADP
fnp-3806	4161	6	bulk	bulk	ADJ
fnp-3806	4161	7	endocytosis	endocytosis	NOUN
fnp-3806	4161	8	and	and	CCONJ
fnp-3806	4161	9	anterogradely	anterogradely	ADV
fnp-3806	4161	10	and	and	CCONJ
fnp-3806	4161	11	retrogradely	retrogradely	ADV
fnp-3806	4161	12	transported	transport	VERB
fnp-3806	4161	13	in	in	ADP
fnp-3806	4161	14	neurons	neuron	NOUN
fnp-3806	4161	15	.	.	PUNCT
fnp-3806	4162	1	j	j	PROPN
fnp-3806	4162	2	biol	biol	PROPN
fnp-3806	4162	3	chem	chem	NOUN
fnp-3806	4162	4	2009	2009	NUM
fnp-3806	4162	5	;	;	PUNCT
fnp-3806	4162	6	284:12845	284:12845	NUM
fnp-3806	4162	7	-	-	SYM
fnp-3806	4162	8	12852	12852	NUM
fnp-3806	4162	9	.	.	PUNCT
fnp-3806	4163	1	https://doi.org/10.1074/jbc.m808759200	https://doi.org/10.1074/jbc.m808759200	X
fnp-3806	4163	2	simons	simons	PROPN
fnp-3806	4163	3	m	m	PROPN
fnp-3806	4163	4	,	,	PUNCT
fnp-3806	4163	5	raposo	raposo	VERB
fnp-3806	4163	6	g.	g.	PROPN
fnp-3806	4163	7	exosomes	exosome	NOUN
fnp-3806	4163	8	--	--	PUNCT
fnp-3806	4163	9	vesicular	vesicular	ADJ
fnp-3806	4163	10	carriers	carrier	NOUN
fnp-3806	4163	11	for	for	ADP
fnp-3806	4163	12	intercellular	intercellular	ADJ
fnp-3806	4163	13	communication	communication	NOUN
fnp-3806	4163	14	.	.	PUNCT
fnp-3806	4164	1	curr	curr	PROPN
fnp-3806	4164	2	opin	opin	NOUN
fnp-3806	4164	3	cell	cell	NOUN
fnp-3806	4164	4	biol	biol	NOUN
fnp-3806	4164	5	2009;21:575	2009;21:575	NOUN
fnp-3806	4164	6	-	-	SYM
fnp-3806	4164	7	581	581	NUM
fnp-3806	4164	8	.	.	PUNCT
fnp-3806	4165	1	https://doi.org/10.1016/j.ceb.2009.03.007	https://doi.org/10.1016/j.ceb.2009.03.007	VERB
fnp-3806	4165	2	wu	wu	PROPN
fnp-3806	4165	3	jw	jw	PROPN
fnp-3806	4165	4	,	,	PUNCT
fnp-3806	4165	5	herman	herman	PROPN
fnp-3806	4165	6	m	m	PROPN
fnp-3806	4165	7	,	,	PUNCT
fnp-3806	4165	8	liu	liu	PROPN
fnp-3806	4165	9	l	l	PROPN
fnp-3806	4165	10	,	,	PUNCT
fnp-3806	4165	11	et	et	PROPN
fnp-3806	4165	12	al	al	PROPN
fnp-3806	4165	13	.	.	PROPN
fnp-3806	4166	1	small	small	PROPN
fnp-3806	4166	2	misfolded	misfolde	VERB
fnp-3806	4166	3	tau	tau	PROPN
fnp-3806	4166	4	species	specie	NOUN
fnp-3806	4166	5	are	be	AUX
fnp-3806	4166	6	internalized	internalize	VERB
fnp-3806	4166	7	via	via	ADP
fnp-3806	4166	8	bulk	bulk	ADJ
fnp-3806	4166	9	endocytosis	endocytosis	NOUN
fnp-3806	4166	10	and	and	CCONJ
fnp-3806	4166	11	anterogradely	anterogradely	ADV
fnp-3806	4166	12	and	and	CCONJ
fnp-3806	4166	13	retrogradely	retrogradely	ADV
fnp-3806	4166	14	transported	transport	VERB
fnp-3806	4166	15	in	in	ADP
fnp-3806	4166	16	neurons	neuron	NOUN
fnp-3806	4166	17	.	.	PUNCT
fnp-3806	4167	1	j	j	PROPN
fnp-3806	4167	2	biol	biol	PROPN
fnp-3806	4167	3	chem	chem	NOUN
fnp-3806	4167	4	2013	2013	NUM
fnp-3806	4167	5	;	;	PUNCT
fnp-3806	4167	6	288:1856	288:1856	X
fnp-3806	4167	7	-	-	NOUN
fnp-3806	4167	8	1870	1870	NUM
fnp-3806	4167	9	.	.	PUNCT
fnp-3806	4168	1	https://doi.org/10.1074/jbc.m112.394528	https://doi.org/10.1074/jbc.m112.394528	NUM
fnp-3806	4168	2	holmes	holmes	PROPN
fnp-3806	4168	3	bb	bb	PROPN
fnp-3806	4168	4	,	,	PUNCT
fnp-3806	4168	5	devos	devos	PROPN
fnp-3806	4168	6	sl	sl	PROPN
fnp-3806	4168	7	,	,	PUNCT
fnp-3806	4168	8	kfoury	kfoury	PROPN
fnp-3806	4168	9	n	n	CCONJ
fnp-3806	4168	10	,	,	PUNCT
fnp-3806	4168	11	et	et	PROPN
fnp-3806	4168	12	al	al	PROPN
fnp-3806	4168	13	.	.	PUNCT
fnp-3806	4169	1	heparan	heparan	ADJ
fnp-3806	4169	2	sulfate	sulfate	NOUN
fnp-3806	4169	3	proteoglycans	proteoglycan	NOUN
fnp-3806	4169	4	mediate	mediate	VERB
fnp-3806	4169	5	internalization	internalization	NOUN
fnp-3806	4169	6	and	and	CCONJ
fnp-3806	4169	7	propagation	propagation	NOUN
fnp-3806	4169	8	of	of	ADP
fnp-3806	4169	9	specific	specific	ADJ
fnp-3806	4169	10	proteopathic	proteopathic	ADJ
fnp-3806	4169	11	seeds	seed	NOUN
fnp-3806	4169	12	.	.	PUNCT
fnp-3806	4170	1	proc	proc	PROPN
fnp-3806	4170	2	natl	natl	PROPN
fnp-3806	4170	3	acad	acad	PROPN
fnp-3806	4170	4	sci	sci	PROPN
fnp-3806	4170	5	usa	usa	PROPN
fnp-3806	4170	6	2013;110	2013;110	PROPN
fnp-3806	4170	7	:	:	PUNCT
fnp-3806	4170	8	e3138	e3138	PROPN
fnp-3806	4170	9	-	-	PUNCT
fnp-3806	4170	10	e3147	e3147	PROPN
fnp-3806	4170	11	.	.	PUNCT
fnp-3806	4170	12	https://doi.org/10.1073/pnas.1301440110	https://doi.org/10.1073/pnas.1301440110	PROPN
fnp-3806	4171	1	saman	saman	PROPN
fnp-3806	4171	2	s	s	PROPN
fnp-3806	4171	3	,	,	PUNCT
fnp-3806	4171	4	lee	lee	PROPN
fnp-3806	4171	5	nc	nc	PROPN
fnp-3806	4171	6	,	,	PUNCT
fnp-3806	4171	7	inoyo	inoyo	PROPN
fnp-3806	4172	1	i	i	PRON
fnp-3806	4172	2	,	,	PUNCT
fnp-3806	4172	3	et	et	PROPN
fnp-3806	4172	4	al	al	PROPN
fnp-3806	4172	5	.	.	PUNCT
fnp-3806	4172	6	proteins	protein	NOUN
fnp-3806	4172	7	recruited	recruit	VERB
fnp-3806	4172	8	to	to	ADP
fnp-3806	4172	9	exosomes	exosome	NOUN
fnp-3806	4172	10	by	by	ADP
fnp-3806	4172	11	tau	tau	PROPN
fnp-3806	4172	12	overexpression	overexpression	NOUN
fnp-3806	4172	13	implicate	implicate	VERB
fnp-3806	4172	14	novel	novel	ADJ
fnp-3806	4172	15	cellular	cellular	ADJ
fnp-3806	4172	16	mechanisms	mechanism	NOUN
fnp-3806	4172	17	linking	link	VERB
fnp-3806	4172	18	tau	tau	PROPN
fnp-3806	4172	19	secretion	secretion	NOUN
fnp-3806	4172	20	with	with	ADP
fnp-3806	4172	21	alzheimer	alzheimer	PROPN
fnp-3806	4172	22	's	's	PART
fnp-3806	4172	23	disease	disease	NOUN
fnp-3806	4172	24	.	.	PUNCT
fnp-3806	4173	1	j	j	PROPN
fnp-3806	4173	2	alzheimers	alzheimers	PROPN
fnp-3806	4173	3	dis	dis	PROPN
fnp-3806	4174	1	2014;40	2014;40	NUM
fnp-3806	4174	2	:	:	PUNCT
fnp-3806	4174	3	s47	s47	NOUN
fnp-3806	4174	4	-	-	PUNCT
fnp-3806	4174	5	70	70	NUM
fnp-3806	4174	6	.	.	PUNCT
fnp-3806	4175	1	https://doi.org/10.3233/jad-132135	https://doi.org/10.3233/jad-132135	VERB
fnp-3806	4175	2	polanco	polanco	PROPN
fnp-3806	4175	3	jc	jc	PROPN
fnp-3806	4175	4	,	,	PUNCT
fnp-3806	4175	5	scicluna	scicluna	PROPN
fnp-3806	4175	6	bc	bc	PROPN
fnp-3806	4175	7	,	,	PUNCT
fnp-3806	4175	8	hill	hill	PROPN
fnp-3806	4175	9	af	af	PROPN
fnp-3806	4175	10	,	,	PUNCT
fnp-3806	4175	11	et	et	PROPN
fnp-3806	4175	12	al	al	PROPN
fnp-3806	4175	13	.	.	PROPN
fnp-3806	4176	1	extracellular	extracellular	ADJ
fnp-3806	4176	2	vesicles	vesicle	NOUN
fnp-3806	4176	3	isolated	isolate	VERB
fnp-3806	4176	4	from	from	ADP
fnp-3806	4176	5	the	the	DET
fnp-3806	4176	6	brains	brain	NOUN
fnp-3806	4176	7	of	of	ADP
fnp-3806	4176	8	rtg4510	rtg4510	ADJ
fnp-3806	4176	9	mice	mice	NOUN
fnp-3806	4176	10	seed	seed	NOUN
fnp-3806	4176	11	tau	tau	PROPN
fnp-3806	4176	12	protein	protein	NOUN
fnp-3806	4176	13	aggregation	aggregation	NOUN
fnp-3806	4176	14	in	in	ADP
fnp-3806	4176	15	a	a	DET
fnp-3806	4176	16	threshold	threshold	NOUN
fnp-3806	4176	17	-	-	PUNCT
fnp-3806	4176	18	dependent	dependent	ADJ
fnp-3806	4176	19	manner	manner	NOUN
fnp-3806	4176	20	.	.	PUNCT
fnp-3806	4177	1	j	j	PROPN
fnp-3806	4177	2	biol	biol	PROPN
fnp-3806	4177	3	chem	chem	NOUN
fnp-3806	4177	4	2016;291:12445	2016;291:12445	NOUN
fnp-3806	4177	5	-	-	NOUN
fnp-3806	4177	6	12466	12466	NUM
fnp-3806	4177	7	.	.	PUNCT
fnp-3806	4178	1	https://doi.org/10.1074/jbc.m115.709485	https://doi.org/10.1074/jbc.m115.709485	PROPN
fnp-3806	4178	2	wang	wang	PROPN
fnp-3806	4178	3	y	y	PROPN
fnp-3806	4178	4	,	,	PUNCT
fnp-3806	4178	5	balaji	balaji	PROPN
fnp-3806	4178	6	v	v	PROPN
fnp-3806	4178	7	,	,	PUNCT
fnp-3806	4178	8	kaniyappan	kaniyappan	NOUN
fnp-3806	4178	9	s	s	PROPN
fnp-3806	4178	10	,	,	PUNCT
fnp-3806	4178	11	et	et	PROPN
fnp-3806	4178	12	al	al	PROPN
fnp-3806	4178	13	.	.	PUNCT
fnp-3806	4179	1	the	the	DET
fnp-3806	4179	2	release	release	NOUN
fnp-3806	4179	3	and	and	CCONJ
fnp-3806	4179	4	trans	trans	ADJ
fnp-3806	4179	5	-	-	ADJ
fnp-3806	4179	6	synaptic	synaptic	ADJ
fnp-3806	4179	7	transmission	transmission	NOUN
fnp-3806	4179	8	of	of	ADP
fnp-3806	4179	9	tau	tau	PROPN
fnp-3806	4179	10	via	via	ADP
fnp-3806	4179	11	exosomes	exosome	NOUN
fnp-3806	4179	12	.	.	PUNCT
fnp-3806	4180	1	mol	mol	ADP
fnp-3806	4180	2	neurodegener	neurodegener	PROPN
fnp-3806	4180	3	2017;12	2017;12	NOUN
fnp-3806	4180	4	:	:	PUNCT
fnp-3806	4180	5	5	5	NUM
fnp-3806	4180	6	.	.	X
fnp-3806	4181	1	https://doi.org/10.1186/s13024-016-0143-y	https://doi.org/10.1186/s13024-016-0143-y	PROPN
fnp-3806	4181	2	demaegd	demaegd	PROPN
fnp-3806	4181	3	k	k	PROPN
fnp-3806	4181	4	,	,	PUNCT
fnp-3806	4181	5	schymkowitz	schymkowitz	PROPN
fnp-3806	4181	6	j	j	PROPN
fnp-3806	4181	7	,	,	PUNCT
fnp-3806	4181	8	rousseau	rousseau	PROPN
fnp-3806	4181	9	f.	f.	PROPN
fnp-3806	4181	10	transcellular	transcellular	PROPN
fnp-3806	4181	11	spreading	spread	VERB
fnp-3806	4181	12	of	of	ADP
fnp-3806	4181	13	tau	tau	PROPN
fnp-3806	4181	14	in	in	ADP
fnp-3806	4181	15	tauopathies	tauopathie	NOUN
fnp-3806	4181	16	.	.	PUNCT
fnp-3806	4182	1	chembiochem	chembiochem	PROPN
fnp-3806	4182	2	2018;19:2424	2018;19:2424	NUM
fnp-3806	4182	3	-	-	SYM
fnp-3806	4182	4	2432	2432	NUM
fnp-3806	4182	5	.	.	PUNCT
fnp-3806	4183	1	https://doi.org/10.1002/cbic.201800288	https://doi.org/10.1002/cbic.201800288	PROPN
fnp-3806	4183	2	jiang	jiang	PROPN
fnp-3806	4183	3	l	l	PROPN
fnp-3806	4183	4	,	,	PUNCT
fnp-3806	4183	5	dong	dong	PROPN
fnp-3806	4183	6	h	h	PROPN
fnp-3806	4183	7	,	,	PUNCT
fnp-3806	4183	8	cao	cao	PROPN
fnp-3806	4183	9	h	h	PROPN
fnp-3806	4183	10	,	,	PUNCT
fnp-3806	4183	11	et	et	PROPN
fnp-3806	4183	12	al	al	PROPN
fnp-3806	4183	13	.	.	PROPN
fnp-3806	4183	14	exosomes	exosome	NOUN
fnp-3806	4183	15	in	in	ADP
fnp-3806	4183	16	pathogenesis	pathogenesis	NOUN
fnp-3806	4183	17	,	,	PUNCT
fnp-3806	4183	18	diagnosis	diagnosis	NOUN
fnp-3806	4183	19	,	,	PUNCT
fnp-3806	4183	20	and	and	CCONJ
fnp-3806	4183	21	treatment	treatment	NOUN
fnp-3806	4183	22	of	of	ADP
fnp-3806	4183	23	alzheimer	alzheimer	PROPN
fnp-3806	4183	24	's	's	PART
fnp-3806	4183	25	disease	disease	NOUN
fnp-3806	4183	26	.	.	PUNCT
fnp-3806	4184	1	med	med	PROPN
fnp-3806	4184	2	sci	sci	PROPN
fnp-3806	4184	3	monit	monit	NOUN
fnp-3806	4184	4	2019;25:3329	2019;25:3329	PROPN
fnp-3806	4184	5	-	-	PUNCT
fnp-3806	4184	6	3335	3335	NUM
fnp-3806	4184	7	.	.	PUNCT
fnp-3806	4185	1	https://doi.org/10.12659/msm.914027	https://doi.org/10.12659/msm.914027	PROPN
fnp-3806	4185	2	pérez	pérez	PROPN
fnp-3806	4185	3	m	m	PROPN
fnp-3806	4185	4	,	,	PUNCT
fnp-3806	4185	5	avila	avila	PROPN
fnp-3806	4185	6	j	j	PROPN
fnp-3806	4185	7	,	,	PUNCT
fnp-3806	4185	8	hernández	hernández	PROPN
fnp-3806	4185	9	f.	f.	PROPN
fnp-3806	4185	10	propagation	propagation	PROPN
fnp-3806	4185	11	of	of	ADP
fnp-3806	4185	12	tau	tau	PROPN
fnp-3806	4185	13	via	via	ADP
fnp-3806	4185	14	extracellular	extracellular	ADJ
fnp-3806	4185	15	vesicles	vesicle	NOUN
fnp-3806	4185	16	.	.	PUNCT
fnp-3806	4186	1	front	front	ADJ
fnp-3806	4186	2	neurosci	neurosci	NOUN
fnp-3806	4186	3	2019;13:698	2019;13:698	NUM
fnp-3806	4186	4	.	.	PUNCT
fnp-3806	4187	1	https://doi.org/10.3389/fnins.2019.00698	https://doi.org/10.3389/fnins.2019.00698	PROPN
fnp-3806	4187	2	iba	iba	PROPN
fnp-3806	4187	3	m	m	PROPN
fnp-3806	4187	4	,	,	PUNCT
fnp-3806	4187	5	guo	guo	PROPN
fnp-3806	4187	6	jl	jl	PROPN
fnp-3806	4187	7	,	,	PUNCT
fnp-3806	4187	8	mcbride	mcbride	PROPN
fnp-3806	4187	9	jd	jd	PROPN
fnp-3806	4187	10	,	,	PUNCT
fnp-3806	4187	11	et	et	PROPN
fnp-3806	4187	12	al	al	PROPN
fnp-3806	4187	13	.	.	PUNCT
fnp-3806	4188	1	synthetic	synthetic	ADJ
fnp-3806	4188	2	tau	tau	PROPN
fnp-3806	4188	3	fibrils	fibril	VERB
fnp-3806	4188	4	mediate	mediate	VERB
fnp-3806	4188	5	transmission	transmission	NOUN
fnp-3806	4188	6	of	of	ADP
fnp-3806	4188	7	neurofibrillary	neurofibrillary	ADJ
fnp-3806	4188	8	tangles	tangle	NOUN
fnp-3806	4188	9	in	in	ADP
fnp-3806	4188	10	a	a	DET
fnp-3806	4188	11	transgenic	transgenic	NOUN
fnp-3806	4188	12	mouse	mouse	NOUN
fnp-3806	4188	13	model	model	NOUN
fnp-3806	4188	14	of	of	ADP
fnp-3806	4188	15	alzheimer's	alzheimer's	NOUN
fnp-3806	4188	16	-	-	PUNCT
fnp-3806	4188	17	like	like	ADJ
fnp-3806	4188	18	tauopathy	tauopathy	NOUN
fnp-3806	4188	19	.	.	PUNCT
fnp-3806	4189	1	j	j	PROPN
fnp-3806	4189	2	neurosci	neurosci	PROPN
fnp-3806	4189	3	2013	2013	NUM
fnp-3806	4189	4	;	;	PUNCT
fnp-3806	4189	5	33	33	NUM
fnp-3806	4189	6	:	:	SYM
fnp-3806	4189	7	1024	1024	NUM
fnp-3806	4189	8	-	-	SYM
fnp-3806	4189	9	1037	1037	NUM
fnp-3806	4189	10	.	.	PUNCT
fnp-3806	4190	1	https://doi.org/10.1523/jneurosci.2642-12.2013	https://doi.org/10.1523/jneurosci.2642-12.2013	ADJ
fnp-3806	4190	2	peeraer	peeraer	NOUN
fnp-3806	4190	3	e	e	NOUN
fnp-3806	4190	4	,	,	PUNCT
fnp-3806	4190	5	bottelbergs	bottelbergs	X
fnp-3806	4190	6	a	a	PRON
fnp-3806	4190	7	,	,	PUNCT
fnp-3806	4190	8	van	van	PROPN
fnp-3806	4190	9	kolen	kolen	PROPN
fnp-3806	4190	10	k	k	PROPN
fnp-3806	4190	11	,	,	PUNCT
fnp-3806	4190	12	et	et	PROPN
fnp-3806	4190	13	al	al	PROPN
fnp-3806	4190	14	.	.	PUNCT
fnp-3806	4191	1	intracerebral	intracerebral	ADJ
fnp-3806	4191	2	injection	injection	NOUN
fnp-3806	4191	3	of	of	ADP
fnp-3806	4191	4	preformed	preformed	ADJ
fnp-3806	4191	5	synthetic	synthetic	ADJ
fnp-3806	4191	6	fibrils	fibril	NOUN
fnp-3806	4191	7	initiates	initiate	VERB
fnp-3806	4191	8	widesprad	widesprad	ADJ
fnp-3806	4191	9	tauopathy	tauopathy	NOUN
fnp-3806	4191	10	and	and	CCONJ
fnp-3806	4191	11	neuronal	neuronal	ADJ
fnp-3806	4191	12	loss	loss	NOUN
fnp-3806	4191	13	in	in	ADP
fnp-3806	4191	14	the	the	DET
fnp-3806	4191	15	brains	brain	NOUN
fnp-3806	4191	16	of	of	ADP
fnp-3806	4191	17	tau	tau	PROPN
fnp-3806	4191	18	transgenic	transgenic	NOUN
fnp-3806	4191	19	mice	mouse	NOUN
fnp-3806	4191	20	.	.	PUNCT
fnp-3806	4192	1	neurobiol	neurobiol	PROPN
fnp-3806	4192	2	dis	dis	PROPN
fnp-3806	4192	3	2015;73:83	2015;73:83	NUM
fnp-3806	4192	4	-	-	SYM
fnp-3806	4192	5	95	95	NUM
fnp-3806	4192	6	.	.	PUNCT
fnp-3806	4193	1	https://doi.org/10.1016/j.nbd.2014.08.032	https://doi.org/10.1016/j.nbd.2014.08.032	PROPN
fnp-3806	4193	2	ahmed	ahmed	PROPN
fnp-3806	4193	3	z	z	PROPN
fnp-3806	4193	4	,	,	PUNCT
fnp-3806	4193	5	cooper	cooper	PROPN
fnp-3806	4193	6	j	j	PROPN
fnp-3806	4193	7	,	,	PUNCT
fnp-3806	4193	8	murray	murray	PROPN
fnp-3806	4193	9	tk	tk	PROPN
fnp-3806	4193	10	,	,	PUNCT
fnp-3806	4193	11	et	et	PROPN
fnp-3806	4193	12	al	al	PROPN
fnp-3806	4193	13	.	.	PUNCT
fnp-3806	4194	1	a	a	DET
fnp-3806	4194	2	novel	novel	NOUN
fnp-3806	4194	3	in	in	ADP
fnp-3806	4194	4	vivo	vivo	NOUN
fnp-3806	4194	5	model	model	NOUN
fnp-3806	4194	6	of	of	ADP
fnp-3806	4194	7	tau	tau	PROPN
fnp-3806	4194	8	propagation	propagation	NOUN
fnp-3806	4194	9	with	with	ADP
fnp-3806	4194	10	rapid	rapid	ADJ
fnp-3806	4194	11	and	and	CCONJ
fnp-3806	4194	12	progressive	progressive	ADJ
fnp-3806	4194	13	neurofibrillary	neurofibrillary	ADJ
fnp-3806	4194	14	tangle	tangle	NOUN
fnp-3806	4194	15	pathology	pathology	NOUN
fnp-3806	4194	16	:	:	PUNCT
fnp-3806	4194	17	the	the	DET
fnp-3806	4194	18	pattern	pattern	NOUN
fnp-3806	4194	19	of	of	ADP
fnp-3806	4194	20	spread	spread	NOUN
fnp-3806	4194	21	is	be	AUX
fnp-3806	4194	22	determined	determine	VERB
fnp-3806	4194	23	by	by	ADP
fnp-3806	4194	24	connectivity	connectivity	NOUN
fnp-3806	4194	25	,	,	PUNCT
fnp-3806	4194	26	not	not	PART
fnp-3806	4194	27	proximity	proximity	NOUN
fnp-3806	4194	28	.	.	PUNCT
fnp-3806	4195	1	acta	acta	PROPN
fnp-3806	4195	2	neuropathol	neuropathol	PROPN
fnp-3806	4195	3	2014;127:667	2014;127:667	NUM
fnp-3806	4195	4	-	-	SYM
fnp-3806	4195	5	683	683	NUM
fnp-3806	4195	6	.	.	PUNCT
fnp-3806	4196	1	https://doi.org/10.1007/s00401-014-1254-6	https://doi.org/10.1007/s00401-014-1254-6	PROPN
fnp-3806	4196	2	clavaguera	clavaguera	PROPN
fnp-3806	4196	3	f	f	PROPN
fnp-3806	4196	4	,	,	PUNCT
fnp-3806	4196	5	bolmont	bolmont	PROPN
fnp-3806	4196	6	t	t	PROPN
fnp-3806	4196	7	,	,	PUNCT
fnp-3806	4196	8	crowther	crowther	PROPN
fnp-3806	4196	9	ra	ra	PROPN
fnp-3806	4196	10	,	,	PUNCT
fnp-3806	4196	11	et	et	PROPN
fnp-3806	4196	12	al	al	PROPN
fnp-3806	4196	13	.	.	PUNCT
fnp-3806	4196	14	transmission	transmission	NOUN
fnp-3806	4196	15	and	and	CCONJ
fnp-3806	4196	16	spreading	spread	VERB
fnp-3806	4196	17	of	of	ADP
fnp-3806	4196	18	tauopathy	tauopathy	NOUN
fnp-3806	4196	19	in	in	ADP
fnp-3806	4196	20	transgenic	transgenic	NOUN
fnp-3806	4196	21	mouse	mouse	NOUN
fnp-3806	4196	22	brain	brain	NOUN
fnp-3806	4196	23	.	.	PUNCT
fnp-3806	4197	1	nat	nat	NOUN
fnp-3806	4197	2	cell	cell	NOUN
fnp-3806	4197	3	biol	biol	PROPN
fnp-3806	4197	4	2009	2009	NUM
fnp-3806	4197	5	;	;	PUNCT
fnp-3806	4197	6	111:909	111:909	NUM
fnp-3806	4197	7	-	-	SYM
fnp-3806	4197	8	913	913	NUM
fnp-3806	4197	9	.	.	PUNCT
fnp-3806	4198	1	https://doi.org/10.1038/ncb1901	https://doi.org/10.1038/ncb1901	PROPN
fnp-3806	4198	2	clavaguera	clavaguera	PROPN
fnp-3806	4198	3	f	f	PROPN
fnp-3806	4198	4	,	,	PUNCT
fnp-3806	4198	5	akatsu	akatsu	ADJ
fnp-3806	4198	6	h	h	NOUN
fnp-3806	4198	7	,	,	PUNCT
fnp-3806	4198	8	fraser	fraser	PROPN
fnp-3806	4198	9	g	g	PROPN
fnp-3806	4198	10	,	,	PUNCT
fnp-3806	4198	11	et	et	PROPN
fnp-3806	4198	12	al	al	PROPN
fnp-3806	4198	13	.	.	PUNCT
fnp-3806	4198	14	brain	brain	NOUN
fnp-3806	4198	15	homogenates	homogenate	NOUN
fnp-3806	4198	16	from	from	ADP
fnp-3806	4198	17	human	human	ADJ
fnp-3806	4198	18	tauopathies	tauopathie	NOUN
fnp-3806	4198	19	induce	induce	VERB
fnp-3806	4198	20	tau	tau	PROPN
fnp-3806	4198	21	inclusions	inclusion	NOUN
fnp-3806	4198	22	in	in	ADP
fnp-3806	4198	23	mouse	mouse	NOUN
fnp-3806	4198	24	brain	brain	NOUN
fnp-3806	4198	25	.	.	PUNCT
fnp-3806	4199	1	proc	proc	PROPN
fnp-3806	4199	2	natl	natl	PROPN
fnp-3806	4199	3	acad	acad	PROPN
fnp-3806	4199	4	sci	sci	PROPN
fnp-3806	4199	5	usa	usa	PROPN
fnp-3806	4199	6	2013	2013	NUM
fnp-3806	4199	7	;	;	PUNCT
fnp-3806	4199	8	110:9535	110:9535	NUM
fnp-3806	4199	9	-	-	SYM
fnp-3806	4199	10	9540	9540	NUM
fnp-3806	4199	11	.	.	PUNCT
fnp-3806	4200	1	https://doi.org/10.1073/pnas.1301175110	https://doi.org/10.1073/pnas.1301175110	ADJ
fnp-3806	4200	2	boluda	boluda	PROPN
fnp-3806	4200	3	s	s	PROPN
fnp-3806	4200	4	,	,	PUNCT
fnp-3806	4200	5	iba	iba	PROPN
fnp-3806	4200	6	m	m	PROPN
fnp-3806	4200	7	,	,	PUNCT
fnp-3806	4200	8	zhang	zhang	PROPN
fnp-3806	4200	9	b	b	PROPN
fnp-3806	4200	10	,	,	PUNCT
fnp-3806	4200	11	et	et	PROPN
fnp-3806	4200	12	al	al	PROPN
fnp-3806	4200	13	.	.	PROPN
fnp-3806	4200	14	differential	differential	ADJ
fnp-3806	4200	15	induction	induction	NOUN
fnp-3806	4200	16	and	and	CCONJ
fnp-3806	4200	17	spread	spread	NOUN
fnp-3806	4200	18	of	of	ADP
fnp-3806	4200	19	tau	tau	PROPN
fnp-3806	4200	20	pathology	pathology	NOUN
fnp-3806	4200	21	in	in	ADP
fnp-3806	4200	22	young	young	ADJ
fnp-3806	4200	23	ps19	ps19	PROPN
fnp-3806	4200	24	tau	tau	PROPN
fnp-3806	4200	25	transgenic	transgenic	NOUN
fnp-3806	4200	26	mice	mouse	NOUN
fnp-3806	4200	27	following	follow	VERB
fnp-3806	4200	28	intracerebral	intracerebral	ADJ
fnp-3806	4200	29	injections	injection	NOUN
fnp-3806	4200	30	of	of	ADP
fnp-3806	4200	31	pathological	pathological	ADJ
fnp-3806	4200	32	tau	tau	PROPN
fnp-3806	4200	33	from	from	ADP
fnp-3806	4200	34	alzheimer	alzheimer	PROPN
fnp-3806	4200	35	’s	’s	PART
fnp-3806	4200	36	disease	disease	NOUN
fnp-3806	4200	37	or	or	CCONJ
fnp-3806	4200	38	corticobasal	corticobasal	NOUN
fnp-3806	4200	39	degeneration	degeneration	NOUN
fnp-3806	4200	40	brains	brain	NOUN
fnp-3806	4200	41	.	.	PUNCT
fnp-3806	4201	1	acta	acta	PROPN
fnp-3806	4201	2	neuropathol	neuropathol	PROPN
fnp-3806	4201	3	2015;129:221–237	2015;129:221–237	NUM
fnp-3806	4201	4	.	.	PUNCT
fnp-3806	4202	1	https://doi.org/10.1007/s00401-014-1373-0	https://doi.org/10.1007/s00401-014-1373-0	PROPN
fnp-3806	4202	2	hu	hu	PROPN
fnp-3806	4203	1	w	w	PROPN
fnp-3806	4203	2	,	,	PUNCT
fnp-3806	4203	3	zhang	zhang	PROPN
fnp-3806	4203	4	x	x	PROPN
fnp-3806	4203	5	,	,	PUNCT
fnp-3806	4203	6	tung	tung	PROPN
fnp-3806	4203	7	yc	yc	PROPN
fnp-3806	4203	8	,	,	PUNCT
fnp-3806	4203	9	et	et	PROPN
fnp-3806	4203	10	al	al	PROPN
fnp-3806	4203	11	.	.	PUNCT
fnp-3806	4203	12	hyperphosphorylation	hyperphosphorylation	PROPN
fnp-3806	4203	13	determines	determine	VERB
fnp-3806	4203	14	both	both	CCONJ
fnp-3806	4203	15	the	the	DET
fnp-3806	4203	16	spread	spread	NOUN
fnp-3806	4203	17	and	and	CCONJ
fnp-3806	4203	18	the	the	DET
fnp-3806	4203	19	morphology	morphology	NOUN
fnp-3806	4203	20	of	of	ADP
fnp-3806	4203	21	tau	tau	PROPN
fnp-3806	4203	22	pathology	pathology	PROPN
fnp-3806	4203	23	.	.	PUNCT
fnp-3806	4204	1	alzheimers	alzheimers	PROPN
fnp-3806	4204	2	dement	dement	PROPN
fnp-3806	4204	3	2016;12:1066	2016;12:1066	PROPN
fnp-3806	4204	4	-	-	PUNCT
fnp-3806	4204	5	1077	1077	NUM
fnp-3806	4204	6	.	.	PUNCT
fnp-3806	4205	1	https://doi.org/10.1016/j.jalz.2016.01.014	https://doi.org/10.1016/j.jalz.2016.01.014	VERB
fnp-3806	4205	2	audouard	audouard	PROPN
fnp-3806	4205	3	e	e	NOUN
fnp-3806	4205	4	,	,	PUNCT
fnp-3806	4205	5	houben	houben	PROPN
fnp-3806	4205	6	s	s	PART
fnp-3806	4205	7	,	,	PUNCT
fnp-3806	4205	8	masaracchia	masaracchia	PROPN
fnp-3806	4205	9	c	c	PROPN
fnp-3806	4205	10	,	,	PUNCT
fnp-3806	4205	11	et	et	PROPN
fnp-3806	4205	12	al	al	PROPN
fnp-3806	4205	13	.	.	PROPN
fnp-3806	4205	14	high	high	ADJ
fnp-3806	4205	15	-	-	PUNCT
fnp-3806	4205	16	molecular	molecular	ADJ
fnp-3806	4205	17	weight	weight	NOUN
fnp-3806	4205	18	paired	pair	VERB
fnp-3806	4205	19	helical	helical	ADJ
fnp-3806	4205	20	filaments	filament	NOUN
fnp-3806	4205	21	from	from	ADP
fnp-3806	4205	22	alzheimer	alzheimer	PROPN
fnp-3806	4205	23	brain	brain	NOUN
fnp-3806	4205	24	induces	induce	VERB
fnp-3806	4205	25	seeding	seed	VERB
fnp-3806	4205	26	of	of	ADP
fnp-3806	4205	27	wild	wild	ADJ
fnp-3806	4205	28	-	-	PUNCT
fnp-3806	4205	29	type	type	NOUN
fnp-3806	4205	30	mouse	mouse	NOUN
fnp-3806	4205	31	tau	tau	PROPN
fnp-3806	4205	32	into	into	ADP
fnp-3806	4205	33	argyrophilic	argyrophilic	ADJ
fnp-3806	4205	34	4r	4r	NUM
fnp-3806	4205	35	tau	tau	PROPN
fnp-3806	4205	36	pathology	pathology	NOUN
fnp-3806	4205	37	in	in	ADP
fnp-3806	4205	38	vivo	vivo	NOUN
fnp-3806	4205	39	.	.	PUNCT
fnp-3806	4206	1	am	be	AUX
fnp-3806	4206	2	j	j	NOUN
fnp-3806	4206	3	pathol	pathol	NOUN
fnp-3806	4206	4	2016	2016	NUM
fnp-3806	4206	5	;	;	PUNCT
fnp-3806	4206	6	186:2709	186:2709	NUM
fnp-3806	4206	7	-	-	SYM
fnp-3806	4206	8	2722	2722	NUM
fnp-3806	4206	9	.	.	PUNCT
fnp-3806	4207	1	https://doi.org/10.1016/j.ajpath.2016.06.008	https://doi.org/10.1016/j.ajpath.2016.06.008	PROPN
fnp-3806	4207	2	guo	guo	PROPN
fnp-3806	4207	3	jl	jl	PROPN
fnp-3806	4207	4	,	,	PUNCT
fnp-3806	4207	5	narasimhan	narasimhan	PROPN
fnp-3806	4207	6	s	s	PROPN
fnp-3806	4207	7	,	,	PUNCT
fnp-3806	4207	8	changolkar	changolkar	NOUN
fnp-3806	4207	9	l	l	NOUN
fnp-3806	4207	10	,	,	PUNCT
fnp-3806	4207	11	et	et	PROPN
fnp-3806	4207	12	al	al	PROPN
fnp-3806	4207	13	.	.	PROPN
fnp-3806	4208	1	unique	unique	ADJ
fnp-3806	4208	2	pathological	pathological	ADJ
fnp-3806	4208	3	tau	tau	NOUN
fnp-3806	4208	4	conformers	conformer	NOUN
fnp-3806	4208	5	from	from	ADP
fnp-3806	4208	6	alzheimer	alzheimer	PROPN
fnp-3806	4208	7	’s	’s	PART
fnp-3806	4208	8	brains	brain	NOUN
fnp-3806	4208	9	transmit	transmit	VERB
fnp-3806	4208	10	tau	tau	PROPN
fnp-3806	4208	11	pathology	pathology	NOUN
fnp-3806	4208	12	in	in	ADP
fnp-3806	4208	13	nontransgenic	nontransgenic	ADJ
fnp-3806	4208	14	mice	mouse	NOUN
fnp-3806	4208	15	.	.	PUNCT
fnp-3806	4209	1	j	j	PROPN
fnp-3806	4209	2	exp	exp	NOUN
fnp-3806	4209	3	med	med	PROPN
fnp-3806	4209	4	2016	2016	NUM
fnp-3806	4209	5	;	;	PUNCT
fnp-3806	4209	6	213:2635–2654	213:2635–2654	NUM
fnp-3806	4209	7	.	.	PUNCT
fnp-3806	4210	1	https://doi.org/10.1084/jem.20160833	https://doi.org/10.1084/jem.20160833	NOUN
fnp-3806	4210	2	narashima	narashima	PROPN
fnp-3806	4210	3	s	s	PROPN
fnp-3806	4210	4	,	,	PUNCT
fnp-3806	4210	5	guo	guo	PROPN
fnp-3806	4210	6	jl	jl	PROPN
fnp-3806	4210	7	,	,	PUNCT
fnp-3806	4210	8	changolkar	changolkar	PROPN
fnp-3806	4210	9	l	l	NOUN
fnp-3806	4210	10	,	,	PUNCT
fnp-3806	4210	11	et	et	PROPN
fnp-3806	4210	12	al	al	PROPN
fnp-3806	4210	13	.	.	PROPN
fnp-3806	4211	1	pathological	pathological	PROPN
fnp-3806	4211	2	tau	tau	PROPN
fnp-3806	4211	3	strains	strain	VERB
fnp-3806	4211	4	from	from	ADP
fnp-3806	4211	5	human	human	ADJ
fnp-3806	4211	6	brains	brain	NOUN
fnp-3806	4211	7	recapitulate	recapitulate	VERB
fnp-3806	4211	8	the	the	DET
fnp-3806	4211	9	diversity	diversity	NOUN
fnp-3806	4211	10	of	of	ADP
fnp-3806	4211	11	tauopathies	tauopathie	NOUN
fnp-3806	4211	12	in	in	ADP
fnp-3806	4211	13	non	non	ADJ
fnp-3806	4211	14	-	-	ADJ
fnp-3806	4211	15	transgenic	transgenic	ADJ
fnp-3806	4211	16	mouse	mouse	NOUN
fnp-3806	4211	17	brain	brain	NOUN
fnp-3806	4211	18	.	.	PUNCT
fnp-3806	4212	1	j	j	PROPN
fnp-3806	4212	2	neurosci	neurosci	PROPN
fnp-3806	4212	3	2017;37	2017;37	NUM
fnp-3806	4212	4	:	:	PUNCT
fnp-3806	4212	5	11406	11406	NUM
fnp-3806	4212	6	-	-	SYM
fnp-3806	4212	7	11423	11423	NUM
fnp-3806	4212	8	.	.	PUNCT
fnp-3806	4213	1	https://doi.org/10.1523/jneurosci.1230-17.2017	https://doi.org/10.1523/jneurosci.1230-17.2017	PROPN
fnp-3806	4213	2	ferrer	ferrer	PROPN
fnp-3806	4213	3	i	i	PRON
fnp-3806	4213	4	,	,	PUNCT
fnp-3806	4213	5	aguiló	aguiló	ADV
fnp-3806	4213	6	garcía	garcía	PROPN
fnp-3806	4213	7	m	m	PROPN
fnp-3806	4213	8	,	,	PUNCT
fnp-3806	4213	9	lópez	lópez	PROPN
fnp-3806	4213	10	gonzález	gonzález	PROPN
fnp-3806	4214	1	i	i	PRON
fnp-3806	4214	2	,	,	PUNCT
fnp-3806	4214	3	et	et	PROPN
fnp-3806	4214	4	al	al	PROPN
fnp-3806	4214	5	.	.	PUNCT
fnp-3806	4214	6	aging	age	VERB
fnp-3806	4214	7	-	-	PUNCT
fnp-3806	4214	8	related	relate	VERB
fnp-3806	4214	9	tau	tau	PROPN
fnp-3806	4214	10	astrogliopathy	astrogliopathy	ADJ
fnp-3806	4214	11	(	(	PUNCT
fnp-3806	4214	12	artag	artag	ADJ
fnp-3806	4214	13	):	):	PUNCT
fnp-3806	4214	14	not	not	PART
fnp-3806	4214	15	only	only	ADV
fnp-3806	4214	16	tau	tau	PROPN
fnp-3806	4214	17	phosphorylation	phosphorylation	NOUN
fnp-3806	4214	18	in	in	ADP
fnp-3806	4214	19	astrocytes	astrocyte	NOUN
fnp-3806	4214	20	.	.	PUNCT
fnp-3806	4215	1	brain	brain	NOUN
fnp-3806	4215	2	pathol	pathol	NOUN
fnp-3806	4215	3	2018	2018	NUM
fnp-3806	4215	4	;	;	PUNCT
fnp-3806	4215	5	28	28	NUM
fnp-3806	4215	6	:	:	PUNCT
fnp-3806	4215	7	965	965	NUM
fnp-3806	4215	8	-	-	SYM
fnp-3806	4215	9	985	985	NUM
fnp-3806	4215	10	.	.	PUNCT
fnp-3806	4216	1	https://doi.org/10.1111/bpa.12593	https://doi.org/10.1111/bpa.12593	PROPN
fnp-3806	4216	2	ferrer	ferrer	PROPN
fnp-3806	4216	3	i	i	PROPN
fnp-3806	4216	4	,	,	PUNCT
fnp-3806	4216	5	andrés	andrés	PROPN
fnp-3806	4216	6	-	-	PUNCT
fnp-3806	4216	7	benito	benito	PROPN
fnp-3806	4216	8	p	p	PROPN
fnp-3806	4216	9	,	,	PUNCT
fnp-3806	4216	10	sala	sala	NOUN
fnp-3806	4216	11	-	-	PUNCT
fnp-3806	4216	12	jarque	jarque	PROPN
fnp-3806	4216	13	j	j	PROPN
fnp-3806	4216	14	,	,	PUNCT
fnp-3806	4216	15	et	et	PROPN
fnp-3806	4216	16	al	al	PROPN
fnp-3806	4216	17	.	.	PUNCT
fnp-3806	4216	18	capacity	capacity	NOUN
fnp-3806	4216	19	for	for	ADP
fnp-3806	4216	20	seeding	seed	VERB
fnp-3806	4216	21	and	and	CCONJ
fnp-3806	4216	22	spreading	spread	VERB
fnp-3806	4216	23	of	of	ADP
fnp-3806	4216	24	argyrophilic	argyrophilic	ADJ
fnp-3806	4216	25	grain	grain	NOUN
fnp-3806	4216	26	disease	disease	NOUN
fnp-3806	4216	27	in	in	ADP
fnp-3806	4216	28	a	a	DET
fnp-3806	4216	29	wild	wild	ADJ
fnp-3806	4216	30	-	-	PUNCT
fnp-3806	4216	31	type	type	NOUN
fnp-3806	4216	32	murine	murine	ADJ
fnp-3806	4216	33	model	model	NOUN
fnp-3806	4216	34	;	;	PUNCT
fnp-3806	4216	35	comparisons	comparison	NOUN
fnp-3806	4216	36	with	with	ADP
fnp-3806	4216	37	primary	primary	ADJ
fnp-3806	4216	38	age	age	NOUN
fnp-3806	4216	39	-	-	PUNCT
fnp-3806	4216	40	related	relate	VERB
fnp-3806	4216	41	tauopathy	tauopathy	NOUN
fnp-3806	4216	42	.	.	PUNCT
fnp-3806	4217	1	front	front	NOUN
fnp-3806	4217	2	mol	mol	ADP
fnp-3806	4217	3	neurosci	neurosci	PROPN
fnp-3806	4217	4	2020	2020	NUM
fnp-3806	4217	5	;	;	PUNCT
fnp-3806	4217	6	13:101	13:101	NUM
fnp-3806	4217	7	.	.	PUNCT
fnp-3806	4218	1	https://doi.org/10.3389/fnmol.2020.00101	https://doi.org/10.3389/fnmol.2020.00101	PROPN
fnp-3806	4218	2	ferrer	ferrer	PROPN
fnp-3806	4218	3	i	i	PROPN
fnp-3806	4218	4	,	,	PUNCT
fnp-3806	4218	5	andrés	andrés	PROPN
fnp-3806	4218	6	-	-	PUNCT
fnp-3806	4218	7	benito	benito	PROPN
fnp-3806	4218	8	p	p	PROPN
fnp-3806	4218	9	,	,	PUNCT
fnp-3806	4218	10	zelaya	zelaya	PROPN
fnp-3806	4218	11	mv	mv	PROPN
fnp-3806	4218	12	,	,	PUNCT
fnp-3806	4218	13	et	et	PROPN
fnp-3806	4218	14	al	al	PROPN
fnp-3806	4218	15	.	.	PROPN
fnp-3806	4219	1	familial	familial	ADJ
fnp-3806	4219	2	globular	globular	ADJ
fnp-3806	4219	3	glial	glial	ADJ
fnp-3806	4219	4	tauopathy	tauopathy	NOUN
fnp-3806	4219	5	linked	link	VERB
fnp-3806	4219	6	to	to	ADP
fnp-3806	4219	7	mapt	mapt	ADJ
fnp-3806	4219	8	mutations	mutation	NOUN
fnp-3806	4219	9	:	:	PUNCT
fnp-3806	4219	10	molecular	molecular	ADJ
fnp-3806	4219	11	neuropathology	neuropathology	NOUN
fnp-3806	4219	12	and	and	CCONJ
fnp-3806	4219	13	seeding	seed	VERB
fnp-3806	4219	14	capacity	capacity	NOUN
fnp-3806	4219	15	of	of	ADP
fnp-3806	4219	16	a	a	DET
fnp-3806	4219	17	prototypical	prototypical	ADJ
fnp-3806	4219	18	mixed	mixed	ADJ
fnp-3806	4219	19	neuronal	neuronal	ADJ
fnp-3806	4219	20	and	and	CCONJ
fnp-3806	4219	21	glial	glial	ADJ
fnp-3806	4219	22	tauopathy	tauopathy	NOUN
fnp-3806	4219	23	.	.	PUNCT
fnp-3806	4220	1	acta	acta	PROPN
fnp-3806	4220	2	neuropathol	neuropathol	PROPN
fnp-3806	4220	3	2020;139:735	2020;139:735	NUM
fnp-3806	4220	4	-	-	SYM
fnp-3806	4220	5	771	771	NUM
fnp-3806	4220	6	.	.	PUNCT
fnp-3806	4221	1	https://doi.org/10.1007/s00401-019-02122-9	https://doi.org/10.1007/s00401-019-02122-9	NOUN
fnp-3806	4221	2	ferrer	ferrer	PROPN
fnp-3806	4221	3	i	i	PRON
fnp-3806	4221	4	,	,	PUNCT
fnp-3806	4221	5	aguiló	aguiló	ADV
fnp-3806	4221	6	garcía	garcía	PROPN
fnp-3806	4221	7	m	m	PROPN
fnp-3806	4221	8	,	,	PUNCT
fnp-3806	4221	9	carmona	carmona	PROPN
fnp-3806	4221	10	m	m	PROPN
fnp-3806	4221	11	,	,	PUNCT
fnp-3806	4221	12	et	et	PROPN
fnp-3806	4221	13	al	al	PROPN
fnp-3806	4221	14	.	.	PUNCT
fnp-3806	4222	1	involvement	involvement	NOUN
fnp-3806	4222	2	of	of	ADP
fnp-3806	4222	3	oligodendrocytes	oligodendrocyte	NOUN
fnp-3806	4222	4	in	in	ADP
fnp-3806	4222	5	tau	tau	PROPN
fnp-3806	4222	6	seeding	seed	VERB
fnp-3806	4222	7	and	and	CCONJ
fnp-3806	4222	8	spreading	spread	VERB
fnp-3806	4222	9	in	in	ADP
fnp-3806	4222	10	tauopathies	tauopathie	NOUN
fnp-3806	4222	11	.	.	PUNCT
fnp-3806	4223	1	front	front	ADJ
fnp-3806	4223	2	aging	age	VERB
fnp-3806	4223	3	neurosci	neurosci	NOUN
fnp-3806	4223	4	2019	2019	NUM
fnp-3806	4223	5	;	;	PUNCT
fnp-3806	4223	6	11:112	11:112	NUM
fnp-3806	4223	7	.	.	PUNCT
fnp-3806	4224	1	https://doi.org/10.3389/fnagi.2019.00112	https://doi.org/10.3389/fnagi.2019.00112	PROPN
fnp-3806	4224	2	weitzman	weitzman	NOUN
fnp-3806	4224	3	sa	sa	PROPN
fnp-3806	4224	4	,	,	PUNCT
fnp-3806	4224	5	narasimhan	narasimhan	PROPN
fnp-3806	4224	6	s	s	PROPN
fnp-3806	4224	7	,	,	PUNCT
fnp-3806	4224	8	he	he	PRON
fnp-3806	4224	9	z	z	X
fnp-3806	4224	10	,	,	PUNCT
fnp-3806	4224	11	et	et	PROPN
fnp-3806	4224	12	al	al	PROPN
fnp-3806	4224	13	.	.	PROPN
fnp-3806	4224	14	insoluble	insoluble	PROPN
fnp-3806	4224	15	tau	tau	PROPN
fnp-3806	4224	16	from	from	ADP
fnp-3806	4224	17	human	human	PROPN
fnp-3806	4224	18	ftdp-17	ftdp-17	PROPN
fnp-3806	4224	19	cases	case	NOUN
fnp-3806	4224	20	exhibit	exhibit	VERB
fnp-3806	4224	21	unique	unique	ADJ
fnp-3806	4224	22	transmission	transmission	NOUN
fnp-3806	4224	23	properties	property	NOUN
fnp-3806	4224	24	in	in	ADP
fnp-3806	4224	25	vivo	vivo	NOUN
fnp-3806	4224	26	.	.	PUNCT
fnp-3806	4225	1	j	j	PROPN
fnp-3806	4225	2	neuropathol	neuropathol	PROPN
fnp-3806	4225	3	exp	exp	PROPN
fnp-3806	4225	4	neurol	neurol	PROPN
fnp-3806	4225	5	2020;79	2020;79	NUM
fnp-3806	4225	6	:	:	PUNCT
fnp-3806	4225	7	941	941	NUM
fnp-3806	4225	8	-	-	SYM
fnp-3806	4225	9	949	949	NUM
fnp-3806	4225	10	.	.	PUNCT
fnp-3806	4226	1	https://doi.org/10.1093/jnen/nlaa086	https://doi.org/10.1093/jnen/nlaa086	PROPN
fnp-3806	4226	2	clavaguera	clavaguera	NOUN
fnp-3806	4226	3	f	f	PROPN
fnp-3806	4226	4	,	,	PUNCT
fnp-3806	4226	5	hench	hench	PROPN
fnp-3806	4226	6	j	j	PROPN
fnp-3806	4226	7	,	,	PUNCT
fnp-3806	4226	8	goedert	goedert	PROPN
fnp-3806	4226	9	m	m	PROPN
fnp-3806	4226	10	,	,	PUNCT
fnp-3806	4226	11	et	et	PROPN
fnp-3806	4226	12	al	al	PROPN
fnp-3806	4226	13	.	.	PROPN
fnp-3806	4226	14	invited	invite	VERB
fnp-3806	4226	15	review	review	NOUN
fnp-3806	4226	16	:	:	PUNCT
fnp-3806	4226	17	prion	prion	NOUN
fnp-3806	4226	18	-	-	PUNCT
fnp-3806	4226	19	like	like	ADJ
fnp-3806	4226	20	transmission	transmission	NOUN
fnp-3806	4226	21	and	and	CCONJ
fnp-3806	4226	22	spreading	spread	VERB
fnp-3806	4226	23	of	of	ADP
fnp-3806	4226	24	tau	tau	PROPN
fnp-3806	4226	25	pathology	pathology	PROPN
fnp-3806	4226	26	.	.	PUNCT
fnp-3806	4227	1	neuropathol	neuropathol	PROPN
fnp-3806	4227	2	appl	appl	PROPN
fnp-3806	4227	3	neurobiol	neurobiol	PROPN
fnp-3806	4227	4	2015;41:47	2015;41:47	NUM
fnp-3806	4227	5	-	-	SYM
fnp-3806	4227	6	58	58	NUM
fnp-3806	4227	7	.	.	PUNCT
fnp-3806	4228	1	https://doi.org/10.1111/nan.12197	https://doi.org/10.1111/nan.12197	PROPN
fnp-3806	4228	2	goedert	goedert	PROPN
fnp-3806	4228	3	m	m	PROPN
fnp-3806	4228	4	,	,	PUNCT
fnp-3806	4228	5	spillantini	spillantini	PROPN
fnp-3806	4228	6	mg	mg	PROPN
fnp-3806	4228	7	.	.	PUNCT
fnp-3806	4228	8	propagation	propagation	NOUN
fnp-3806	4228	9	of	of	ADP
fnp-3806	4228	10	tau	tau	PROPN
fnp-3806	4228	11	aggregates	aggregate	NOUN
fnp-3806	4228	12	.	.	PUNCT
fnp-3806	4229	1	mol	mol	ADP
fnp-3806	4229	2	brain	brain	NOUN
fnp-3806	4229	3	2017	2017	NUM
fnp-3806	4229	4	;	;	PUNCT
fnp-3806	4229	5	10:18	10:18	NUM
fnp-3806	4229	6	.	.	PUNCT
fnp-3806	4230	1	https://doi.org/10.1186/s13041-017-0298-7	https://doi.org/10.1186/s13041-017-0298-7	NUM
fnp-3806	4230	2	goedert	goedert	PROPN
fnp-3806	4230	3	m	m	PROPN
fnp-3806	4230	4	,	,	PUNCT
fnp-3806	4230	5	eisenberg	eisenberg	PROPN
fnp-3806	4230	6	ds	ds	PROPN
fnp-3806	4230	7	,	,	PUNCT
fnp-3806	4230	8	crowther	crowther	PROPN
fnp-3806	4230	9	ra	ra	PROPN
fnp-3806	4230	10	.	.	PUNCT
fnp-3806	4231	1	propagation	propagation	NOUN
fnp-3806	4231	2	of	of	ADP
fnp-3806	4231	3	tau	tau	PROPN
fnp-3806	4231	4	aggregates	aggregate	NOUN
fnp-3806	4231	5	and	and	CCONJ
fnp-3806	4231	6	neurodegeneration	neurodegeneration	NOUN
fnp-3806	4231	7	.	.	PUNCT
fnp-3806	4232	1	annu	annu	PROPN
fnp-3806	4232	2	rev	rev	VERB
fnp-3806	4232	3	neurosci	neurosci	PROPN
fnp-3806	4232	4	2017	2017	NUM
fnp-3806	4232	5	;	;	PUNCT
fnp-3806	4232	6	40:189	40:189	NUM
fnp-3806	4232	7	-	-	SYM
fnp-3806	4232	8	210	210	NUM
fnp-3806	4232	9	.	.	PUNCT
fnp-3806	4233	1	https://doi.org/10.1146/annurev-neuro-072116-031153	https://doi.org/10.1146/annurev-neuro-072116-031153	ADJ
fnp-3806	4233	2	vaquer	vaquer	NOUN
fnp-3806	4233	3	-	-	PUNCT
fnp-3806	4233	4	alicea	alicea	PROPN
fnp-3806	4233	5	j	j	PROPN
fnp-3806	4233	6	,	,	PUNCT
fnp-3806	4233	7	diamond	diamond	PROPN
fnp-3806	4233	8	mi	mi	PROPN
fnp-3806	4233	9	,	,	PUNCT
fnp-3806	4233	10	joachimiak	joachimiak	PROPN
fnp-3806	4233	11	la	la	PROPN
fnp-3806	4233	12	.	.	PUNCT
fnp-3806	4234	1	tau	tau	PROPN
fnp-3806	4234	2	strains	strain	VERB
fnp-3806	4234	3	shape	shape	NOUN
fnp-3806	4234	4	disease	disease	NOUN
fnp-3806	4234	5	.	.	PUNCT
fnp-3806	4235	1	acta	acta	PROPN
fnp-3806	4235	2	neuropathologica	neuropathologica	PROPN
fnp-3806	4235	3	2021;142:57	2021;142:57	PROPN
fnp-3806	4235	4	-	-	SYM
fnp-3806	4235	5	71	71	NUM
fnp-3806	4235	6	.	.	PUNCT
fnp-3806	4236	1	https://doi.org/10.1007/s00401-021-02301-7	https://doi.org/10.1007/s00401-021-02301-7	PROPN
fnp-3806	4237	1	li	li	PROPN
fnp-3806	4237	2	l	l	PROPN
fnp-3806	4237	3	,	,	PUNCT
fnp-3806	4237	4	shi	shi	PROPN
fnp-3806	4237	5	r	r	PROPN
fnp-3806	4237	6	,	,	PUNCT
fnp-3806	4237	7	gu	gu	PROPN
fnp-3806	4237	8	j	j	PROPN
fnp-3806	4237	9	,	,	PUNCT
fnp-3806	4238	1	et	et	PROPN
fnp-3806	4238	2	al	al	PROPN
fnp-3806	4238	3	.	.	PROPN
fnp-3806	4238	4	alzheimer	alzheimer	PROPN
fnp-3806	4238	5	's	's	PART
fnp-3806	4238	6	disease	disease	NOUN
fnp-3806	4238	7	brain	brain	NOUN
fnp-3806	4238	8	contains	contain	VERB
fnp-3806	4238	9	tau	tau	PROPN
fnp-3806	4238	10	fractions	fraction	NOUN
fnp-3806	4238	11	with	with	ADP
fnp-3806	4238	12	differential	differential	ADJ
fnp-3806	4238	13	prion	prion	NOUN
fnp-3806	4238	14	-	-	PUNCT
fnp-3806	4238	15	like	like	ADJ
fnp-3806	4238	16	activities	activity	NOUN
fnp-3806	4238	17	.	.	PUNCT
fnp-3806	4239	1	acta	acta	PROPN
fnp-3806	4239	2	neuropathol	neuropathol	PROPN
fnp-3806	4239	3	commun	commun	PROPN
fnp-3806	4239	4	2021;9:28	2021;9:28	NOUN
fnp-3806	4239	5	.	.	PUNCT
fnp-3806	4240	1	https://doi.org/10.1186/s40478-021-01127-4	https://doi.org/10.1186/s40478-021-01127-4	PROPN
fnp-3806	4240	2	dujardin	dujardin	PROPN
fnp-3806	4240	3	s	s	PROPN
fnp-3806	4240	4	,	,	PUNCT
fnp-3806	4240	5	commins	commin	VERB
fnp-3806	4240	6	c	c	NOUN
fnp-3806	4240	7	,	,	PUNCT
fnp-3806	4240	8	lathuiliere	lathuiliere	VERB
fnp-3806	4240	9	a	a	PRON
fnp-3806	4240	10	,	,	PUNCT
fnp-3806	4240	11	et	et	PROPN
fnp-3806	4240	12	al	al	PROPN
fnp-3806	4240	13	.	.	PUNCT
fnp-3806	4241	1	tau	tau	PROPN
fnp-3806	4241	2	molecular	molecular	ADJ
fnp-3806	4241	3	diversity	diversity	NOUN
fnp-3806	4241	4	contributes	contribute	VERB
fnp-3806	4241	5	to	to	ADP
fnp-3806	4241	6	clinical	clinical	ADJ
fnp-3806	4241	7	heterogeneity	heterogeneity	NOUN
fnp-3806	4241	8	in	in	ADP
fnp-3806	4241	9	alzheimer	alzheimer	PROPN
fnp-3806	4241	10	's	's	PART
fnp-3806	4241	11	disease	disease	NOUN
fnp-3806	4241	12	.	.	PUNCT
fnp-3806	4242	1	nat	nat	PROPN
fnp-3806	4242	2	med	me	VERB
fnp-3806	4242	3	2020;26:1256	2020;26:1256	PROPN
fnp-3806	4242	4	-	-	SYM
fnp-3806	4242	5	1263	1263	NUM
fnp-3806	4242	6	.	.	PUNCT
fnp-3806	4243	1	https://doi.org/10.1038/s41591-020-0938-9	https://doi.org/10.1038/s41591-020-0938-9	NOUN
fnp-3806	4243	2	janke	janke	PROPN
fnp-3806	4243	3	c	c	PROPN
fnp-3806	4243	4	,	,	PUNCT
fnp-3806	4243	5	beck	beck	PROPN
fnp-3806	4243	6	m	m	PROPN
fnp-3806	4243	7	,	,	PUNCT
fnp-3806	4243	8	sthal	sthal	PROPN
fnp-3806	4243	9	t	t	PROPN
fnp-3806	4243	10	,	,	PUNCT
fnp-3806	4243	11	et	et	PROPN
fnp-3806	4243	12	al	al	PROPN
fnp-3806	4243	13	.	.	PUNCT
fnp-3806	4244	1	phylogenetic	phylogenetic	ADJ
fnp-3806	4244	2	diversity	diversity	NOUN
fnp-3806	4244	3	of	of	ADP
fnp-3806	4244	4	the	the	DET
fnp-3806	4244	5	expression	expression	NOUN
fnp-3806	4244	6	of	of	ADP
fnp-3806	4244	7	the	the	DET
fnp-3806	4244	8	microtubule	microtubule	NOUN
fnp-3806	4244	9	-	-	PUNCT
fnp-3806	4244	10	associated	associate	VERB
fnp-3806	4244	11	protein	protein	NOUN
fnp-3806	4244	12	tau	tau	NOUN
fnp-3806	4244	13	:	:	PUNCT
fnp-3806	4244	14	implications	implication	NOUN
fnp-3806	4244	15	for	for	ADP
fnp-3806	4244	16	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4244	17	disorders	disorder	NOUN
fnp-3806	4244	18	.	.	PUNCT
fnp-3806	4245	1	brain	brain	NOUN
fnp-3806	4245	2	res	re	NOUN
fnp-3806	4245	3	mol	mol	ADP
fnp-3806	4245	4	brain	brain	NOUN
fnp-3806	4245	5	res	re	NOUN
fnp-3806	4245	6	1999;68:119	1999;68:119	NUM
fnp-3806	4245	7	-	-	SYM
fnp-3806	4245	8	128	128	NUM
fnp-3806	4245	9	.	.	PUNCT
fnp-3806	4246	1	https://doi.org/10.1016/s0169-328x(99)00079-0	https://doi.org/10.1016/s0169-328x(99)00079-0	PRON
fnp-3806	4246	2	ferrer	ferrer	PROPN
fnp-3806	4247	1	i	i	PRON
fnp-3806	4247	2	,	,	PUNCT
fnp-3806	4247	3	zelaya	zelaya	PROPN
fnp-3806	4247	4	v	v	PROPN
fnp-3806	4247	5	,	,	PUNCT
fnp-3806	4247	6	aguio	aguio	PROPN
fnp-3806	4247	7	m	m	PROPN
fnp-3806	4247	8	,	,	PUNCT
fnp-3806	4247	9	et	et	PROPN
fnp-3806	4247	10	al	al	PROPN
fnp-3806	4247	11	.	.	PUNCT
fnp-3806	4247	12	relevance	relevance	NOUN
fnp-3806	4247	13	of	of	ADP
fnp-3806	4247	14	host	host	NOUN
fnp-3806	4247	15	tau	tau	PROPN
fnp-3806	4247	16	in	in	ADP
fnp-3806	4247	17	tau	tau	PROPN
fnp-3806	4247	18	seeding	seed	VERB
fnp-3806	4247	19	and	and	CCONJ
fnp-3806	4247	20	spreading	spread	VERB
fnp-3806	4247	21	in	in	ADP
fnp-3806	4247	22	tauopathies	tauopathie	NOUN
fnp-3806	4247	23	.	.	PUNCT
fnp-3806	4248	1	brain	brain	NOUN
fnp-3806	4248	2	pathol	pathol	NOUN
fnp-3806	4248	3	2020;30:298	2020;30:298	NUM
fnp-3806	4248	4	-	-	SYM
fnp-3806	4248	5	318	318	NUM
fnp-3806	4248	6	.	.	PUNCT
fnp-3806	4249	1	https://doi.org/10.1111/bpa.12778	https://doi.org/10.1111/bpa.12778	PROPN
fnp-3806	4249	2	beckman	beckman	PROPN
fnp-3806	4249	3	d	d	PROPN
fnp-3806	4249	4	,	,	PUNCT
fnp-3806	4249	5	chakrabarty	chakrabarty	PROPN
fnp-3806	4249	6	p	p	X
fnp-3806	4249	7	,	,	PUNCT
fnp-3806	4249	8	ott	ott	PROPN
fnp-3806	4249	9	s	s	PROPN
fnp-3806	4249	10	,	,	PUNCT
fnp-3806	4249	11	et	et	PROPN
fnp-3806	4249	12	al	al	PROPN
fnp-3806	4249	13	.	.	PUNCT
fnp-3806	4250	1	a	a	DET
fnp-3806	4250	2	novel	novel	ADJ
fnp-3806	4250	3	tau	tau	NOUN
fnp-3806	4250	4	-	-	PUNCT
fnp-3806	4250	5	based	base	VERB
fnp-3806	4250	6	rhesus	rhesus	NOUN
fnp-3806	4250	7	monkey	monkey	NOUN
fnp-3806	4250	8	model	model	NOUN
fnp-3806	4250	9	of	of	ADP
fnp-3806	4250	10	alzheimer	alzheimer	PROPN
fnp-3806	4250	11	's	's	PART
fnp-3806	4250	12	pathogenesis	pathogenesis	NOUN
fnp-3806	4250	13	.	.	PUNCT
fnp-3806	4251	1	alzheimers	alzheimers	PROPN
fnp-3806	4251	2	dement	dement	PROPN
fnp-3806	4251	3	2021;17:933	2021;17:933	PROPN
fnp-3806	4251	4	-	-	PUNCT
fnp-3806	4251	5	945	945	NUM
fnp-3806	4251	6	.	.	PUNCT
fnp-3806	4252	1	https://doi.org/10.1002/alz.12318	https://doi.org/10.1002/alz.12318	PROPN
fnp-3806	4252	2	clavaguera	clavaguera	PROPN
fnp-3806	4252	3	f	f	PROPN
fnp-3806	4252	4	,	,	PUNCT
fnp-3806	4252	5	hench	hench	VERB
fnp-3806	4252	6	j	j	PROPN
fnp-3806	4252	7	,	,	PUNCT
fnp-3806	4252	8	lavenir	lavenir	PROPN
fnp-3806	4253	1	i	i	PRON
fnp-3806	4253	2	,	,	PUNCT
fnp-3806	4253	3	et	et	PROPN
fnp-3806	4253	4	al	al	PROPN
fnp-3806	4253	5	.	.	PROPN
fnp-3806	4253	6	peripheral	peripheral	ADJ
fnp-3806	4253	7	administration	administration	NOUN
fnp-3806	4253	8	of	of	ADP
fnp-3806	4253	9	tau	tau	PROPN
fnp-3806	4253	10	aggregates	aggregate	NOUN
fnp-3806	4253	11	triggers	trigger	VERB
fnp-3806	4253	12	intracerebral	intracerebral	ADJ
fnp-3806	4253	13	tauopathy	tauopathy	NOUN
fnp-3806	4253	14	in	in	ADP
fnp-3806	4253	15	transgenic	transgenic	NOUN
fnp-3806	4253	16	mice	mouse	NOUN
fnp-3806	4253	17	.	.	PUNCT
fnp-3806	4254	1	acta	acta	PROPN
fnp-3806	4254	2	neuropathol	neuropathol	PROPN
fnp-3806	4254	3	2014	2014	NUM
fnp-3806	4254	4	;	;	PUNCT
fnp-3806	4254	5	127	127	NUM
fnp-3806	4254	6	:	:	PUNCT
fnp-3806	4254	7	299	299	NUM
fnp-3806	4254	8	-	-	SYM
fnp-3806	4254	9	301	301	NUM
fnp-3806	4254	10	.	.	PUNCT
fnp-3806	4255	1	https://doi.org/10.1007/s00401-013-1231-5	https://doi.org/10.1007/s00401-013-1231-5	PROPN
fnp-3806	4255	2	furman	furman	PROPN
fnp-3806	4255	3	jl	jl	PROPN
fnp-3806	4255	4	,	,	PUNCT
fnp-3806	4255	5	vaquer	vaquer	NOUN
fnp-3806	4255	6	-	-	PUNCT
fnp-3806	4255	7	alicea	alicea	PROPN
fnp-3806	4255	8	j	j	PROPN
fnp-3806	4255	9	,	,	PUNCT
fnp-3806	4255	10	white	white	ADJ
fnp-3806	4255	11	cl	cl	NOUN
fnp-3806	4255	12	,	,	PUNCT
fnp-3806	4255	13	et	et	PROPN
fnp-3806	4255	14	al	al	PROPN
fnp-3806	4255	15	.	.	PROPN
fnp-3806	4256	1	widespread	widespread	ADJ
fnp-3806	4256	2	tau	tau	NOUN
fnp-3806	4256	3	seeding	seed	VERB
fnp-3806	4256	4	activity	activity	NOUN
fnp-3806	4256	5	at	at	ADP
fnp-3806	4256	6	early	early	ADJ
fnp-3806	4256	7	braak	braak	NOUN
fnp-3806	4256	8	stages	stage	NOUN
fnp-3806	4256	9	.	.	PUNCT
fnp-3806	4257	1	acta	acta	PROPN
fnp-3806	4257	2	neuropathol	neuropathol	PROPN
fnp-3806	4257	3	2017;133	2017;133	NUM
fnp-3806	4257	4	:	:	PUNCT
fnp-3806	4257	5	91	91	NUM
fnp-3806	4257	6	-	-	SYM
fnp-3806	4257	7	100	100	NUM
fnp-3806	4257	8	.	.	PUNCT
fnp-3806	4258	1	https://doi.org/10.1007/s00401-016-1644-z	https://doi.org/10.1007/s00401-016-1644-z	PROPN
fnp-3806	4258	2	kaufman	kaufman	PROPN
fnp-3806	4258	3	sk	sk	PROPN
fnp-3806	4258	4	,	,	PUNCT
fnp-3806	4258	5	del	del	PROPN
fnp-3806	4258	6	tredici	tredici	PROPN
fnp-3806	4258	7	k	k	PROPN
fnp-3806	4258	8	,	,	PUNCT
fnp-3806	4258	9	thomas	thomas	PROPN
fnp-3806	4258	10	tl	tl	PROPN
fnp-3806	4258	11	,	,	PUNCT
fnp-3806	4258	12	et	et	PROPN
fnp-3806	4258	13	al	al	PROPN
fnp-3806	4258	14	.	.	PUNCT
fnp-3806	4259	1	tau	tau	PROPN
fnp-3806	4259	2	seeding	seed	VERB
fnp-3806	4259	3	activity	activity	NOUN
fnp-3806	4259	4	begins	begin	VERB
fnp-3806	4259	5	in	in	ADP
fnp-3806	4259	6	the	the	DET
fnp-3806	4259	7	transentorhinal	transentorhinal	ADJ
fnp-3806	4259	8	/	/	SYM
fnp-3806	4259	9	entorhinal	entorhinal	ADJ
fnp-3806	4259	10	regions	region	NOUN
fnp-3806	4259	11	and	and	CCONJ
fnp-3806	4259	12	anticipates	anticipate	VERB
fnp-3806	4259	13	phospho	phospho	ADJ
fnp-3806	4259	14	-	-	PUNCT
fnp-3806	4259	15	tau	tau	NOUN
fnp-3806	4259	16	pathology	pathology	NOUN
fnp-3806	4259	17	in	in	ADP
fnp-3806	4259	18	alzheimer	alzheimer	PROPN
fnp-3806	4259	19	’s	’s	PART
fnp-3806	4259	20	disease	disease	NOUN
fnp-3806	4259	21	and	and	CCONJ
fnp-3806	4259	22	part	part	NOUN
fnp-3806	4259	23	.	.	PUNCT
fnp-3806	4260	1	acta	acta	PROPN
fnp-3806	4260	2	neuropathol	neuropathol	PROPN
fnp-3806	4260	3	2018	2018	NUM
fnp-3806	4260	4	;	;	PUNCT
fnp-3806	4260	5	136:57	136:57	NUM
fnp-3806	4260	6	-	-	SYM
fnp-3806	4260	7	67	67	NUM
fnp-3806	4260	8	.	.	PUNCT
fnp-3806	4261	1	https://doi.org/10.1007/s00401-018-1855-6	https://doi.org/10.1007/s00401-018-1855-6	VERB
fnp-3806	4262	1	seemiller	seemiller	PROPN
fnp-3806	4262	2	j	j	PROPN
fnp-3806	4262	3	,	,	PUNCT
fnp-3806	4262	4	bischof	bischof	PROPN
fnp-3806	4262	5	gn	gn	PROPN
fnp-3806	4262	6	,	,	PUNCT
fnp-3806	4262	7	hoenig	hoenig	PROPN
fnp-3806	4262	8	mc	mc	PROPN
fnp-3806	4262	9	,	,	PUNCT
fnp-3806	4262	10	et	et	PROPN
fnp-3806	4262	11	al	al	PROPN
fnp-3806	4262	12	.	.	PROPN
fnp-3806	4262	13	indication	indication	NOUN
fnp-3806	4262	14	of	of	ADP
fnp-3806	4262	15	retrograde	retrograde	ADJ
fnp-3806	4262	16	tau	tau	PROPN
fnp-3806	4262	17	spreading	spread	VERB
fnp-3806	4262	18	along	along	ADP
fnp-3806	4262	19	braak	braak	NOUN
fnp-3806	4262	20	stages	stage	NOUN
fnp-3806	4262	21	and	and	CCONJ
fnp-3806	4262	22	functional	functional	ADJ
fnp-3806	4262	23	connectivity	connectivity	NOUN
fnp-3806	4262	24	pathways	pathway	NOUN
fnp-3806	4262	25	.	.	PUNCT
fnp-3806	4263	1	eur	eur	PROPN
fnp-3806	4263	2	j	j	PROPN
fnp-3806	4263	3	nucl	nucl	PROPN
fnp-3806	4263	4	med	me	VERB
fnp-3806	4263	5	mol	mol	ADP
fnp-3806	4263	6	imaging	imaging	PROPN
fnp-3806	4263	7	2021	2021	NUM
fnp-3806	4263	8	;	;	PUNCT
fnp-3806	4263	9	48	48	NUM
fnp-3806	4263	10	:	:	PUNCT
fnp-3806	4263	11	2272	2272	NUM
fnp-3806	4263	12	-	-	SYM
fnp-3806	4263	13	2282	2282	NUM
fnp-3806	4263	14	.	.	PUNCT
fnp-3806	4264	1	https://doi.org/10.1007/s00259-020-05183-1	https://doi.org/10.1007/s00259-020-05183-1	NUM
fnp-3806	4264	2	meisl	meisl	PROPN
fnp-3806	4264	3	g	g	PROPN
fnp-3806	4264	4	,	,	PUNCT
fnp-3806	4264	5	hidari	hidari	ADJ
fnp-3806	4264	6	e	e	NOUN
fnp-3806	4264	7	,	,	PUNCT
fnp-3806	4264	8	allinson	allinson	PROPN
fnp-3806	4264	9	k	k	PROPN
fnp-3806	4264	10	,	,	PUNCT
fnp-3806	4264	11	et	et	PROPN
fnp-3806	4264	12	al	al	PROPN
fnp-3806	4264	13	.	.	PROPN
fnp-3806	4265	1	in	in	ADP
fnp-3806	4265	2	vivo	vivo	ADJ
fnp-3806	4265	3	rate	rate	NOUN
fnp-3806	4265	4	-	-	PUNCT
fnp-3806	4265	5	determining	determine	VERB
fnp-3806	4265	6	steps	step	NOUN
fnp-3806	4265	7	of	of	ADP
fnp-3806	4265	8	tau	tau	PROPN
fnp-3806	4265	9	seed	seed	NOUN
fnp-3806	4265	10	accumulation	accumulation	NOUN
fnp-3806	4265	11	in	in	ADP
fnp-3806	4265	12	alzheimer	alzheimer	PROPN
fnp-3806	4265	13	's	's	PART
fnp-3806	4265	14	disease	disease	NOUN
fnp-3806	4265	15	.	.	PUNCT
fnp-3806	4266	1	sci	sci	PROPN
fnp-3806	4266	2	adv	adv	PROPN
fnp-3806	4266	3	2021;7	2021;7	NUM
fnp-3806	4266	4	:	:	PUNCT
fnp-3806	4266	5	eabh1448	eabh1448	PROPN
fnp-3806	4266	6	.	.	PUNCT
fnp-3806	4267	1	https://doi.org/10.1126/sciadv.abh1448	https://doi.org/10.1126/sciadv.abh1448	PROPN
fnp-3806	4267	2	andrés	andrés	PROPN
fnp-3806	4267	3	-	-	PUNCT
fnp-3806	4267	4	benito	benito	PROPN
fnp-3806	4267	5	p	p	PROPN
fnp-3806	4267	6	,	,	PUNCT
fnp-3806	4267	7	carmona	carmona	PROPN
fnp-3806	4267	8	m	m	PROPN
fnp-3806	4267	9	,	,	PUNCT
fnp-3806	4267	10	jordán	jordán	PROPN
fnp-3806	4267	11	m	m	PROPN
fnp-3806	4267	12	,	,	PUNCT
fnp-3806	4267	13	et	et	PROPN
fnp-3806	4267	14	al	al	PROPN
fnp-3806	4267	15	.	.	PROPN
fnp-3806	4268	1	host	host	PROPN
fnp-3806	4268	2	tau	tau	PROPN
fnp-3806	4268	3	genotype	genotype	VERB
fnp-3806	4268	4	specifically	specifically	ADV
fnp-3806	4268	5	designs	design	VERB
fnp-3806	4268	6	and	and	CCONJ
fnp-3806	4268	7	regulates	regulate	VERB
fnp-3806	4268	8	tau	tau	PROPN
fnp-3806	4268	9	seeding	seed	VERB
fnp-3806	4268	10	and	and	CCONJ
fnp-3806	4268	11	spreading	spread	VERB
fnp-3806	4268	12	and	and	CCONJ
fnp-3806	4268	13	host	host	NOUN
fnp-3806	4268	14	tau	tau	PROPN
fnp-3806	4268	15	transformation	transformation	NOUN
fnp-3806	4268	16	following	follow	VERB
fnp-3806	4268	17	intrahippocampal	intrahippocampal	ADJ
fnp-3806	4268	18	injection	injection	NOUN
fnp-3806	4268	19	of	of	ADP
fnp-3806	4268	20	identical	identical	ADJ
fnp-3806	4268	21	tau	tau	PROPN
fnp-3806	4268	22	ad	ad	NOUN
fnp-3806	4268	23	inoculum	inoculum	NOUN
fnp-3806	4268	24	.	.	PUNCT
fnp-3806	4269	1	int	int	PROPN
fnp-3806	4269	2	j	j	PROPN
fnp-3806	4269	3	mol	mol	ADP
fnp-3806	4269	4	sci	sci	PROPN
fnp-3806	4269	5	2022;23:718	2022;23:718	NUM
fnp-3806	4269	6	.	.	PUNCT
fnp-3806	4270	1	https://doi.org/10.3390/ijms23020718	https://doi.org/10.3390/ijms23020718	PROPN
fnp-3806	4270	2	detrez	detrez	PROPN
fnp-3806	4270	3	jr	jr	PROPN
fnp-3806	4270	4	,	,	PUNCT
fnp-3806	4270	5	maurin	maurin	NOUN
fnp-3806	4270	6	h	h	NOUN
fnp-3806	4270	7	,	,	PUNCT
fnp-3806	4270	8	van	van	PROPN
fnp-3806	4270	9	kolen	kolen	PROPN
fnp-3806	4270	10	k	k	PROPN
fnp-3806	4270	11	,	,	PUNCT
fnp-3806	4270	12	et	et	PROPN
fnp-3806	4270	13	al	al	PROPN
fnp-3806	4270	14	.	.	PROPN
fnp-3806	4271	1	regional	regional	ADJ
fnp-3806	4271	2	vulnerability	vulnerability	NOUN
fnp-3806	4271	3	and	and	CCONJ
fnp-3806	4271	4	spreading	spread	VERB
fnp-3806	4271	5	of	of	ADP
fnp-3806	4271	6	hyperphosphorylated	hyperphosphorylated	ADJ
fnp-3806	4271	7	tau	tau	PROPN
fnp-3806	4271	8	in	in	ADP
fnp-3806	4271	9	seeded	seeded	ADJ
fnp-3806	4271	10	mouse	mouse	NOUN
fnp-3806	4271	11	brain	brain	NOUN
fnp-3806	4271	12	.	.	PUNCT
fnp-3806	4272	1	neurobiol	neurobiol	PROPN
fnp-3806	4272	2	dis	dis	PROPN
fnp-3806	4272	3	2019;127:398	2019;127:398	NUM
fnp-3806	4272	4	-	-	SYM
fnp-3806	4272	5	409	409	NUM
fnp-3806	4272	6	.	.	PUNCT
fnp-3806	4273	1	https://doi.org/10.1016/j.nbd.2019.03.010	https://doi.org/10.1016/j.nbd.2019.03.010	AUX
fnp-3806	4273	2	maphis	maphis	PRON
fnp-3806	4273	3	n	n	CCONJ
fnp-3806	4273	4	,	,	PUNCT
fnp-3806	4273	5	xu	xu	PROPN
fnp-3806	4273	6	g	g	PROPN
fnp-3806	4273	7	,	,	PUNCT
fnp-3806	4273	8	kokiko	kokiko	PROPN
fnp-3806	4273	9	-	-	PUNCT
fnp-3806	4273	10	cochran	cochran	NOUN
fnp-3806	4273	11	on	on	ADP
fnp-3806	4273	12	,	,	PUNCT
fnp-3806	4273	13	et	et	PROPN
fnp-3806	4273	14	al	al	PROPN
fnp-3806	4273	15	.	.	PROPN
fnp-3806	4273	16	reactive	reactive	ADJ
fnp-3806	4273	17	microglia	microglia	NOUN
fnp-3806	4273	18	drive	drive	NOUN
fnp-3806	4273	19	tau	tau	PROPN
fnp-3806	4273	20	pathology	pathology	NOUN
fnp-3806	4273	21	and	and	CCONJ
fnp-3806	4273	22	contribute	contribute	VERB
fnp-3806	4273	23	to	to	ADP
fnp-3806	4273	24	the	the	DET
fnp-3806	4273	25	spreading	spreading	NOUN
fnp-3806	4273	26	of	of	ADP
fnp-3806	4273	27	pathological	pathological	ADJ
fnp-3806	4273	28	tau	tau	NOUN
fnp-3806	4273	29	in	in	ADP
fnp-3806	4273	30	the	the	DET
fnp-3806	4273	31	brain	brain	NOUN
fnp-3806	4273	32	.	.	PUNCT
fnp-3806	4274	1	brain	brain	NOUN
fnp-3806	4274	2	2015;138:1738	2015;138:1738	NUM
fnp-3806	4274	3	-	-	SYM
fnp-3806	4274	4	1755	1755	NUM
fnp-3806	4274	5	.	.	PUNCT
fnp-3806	4275	1	https://doi.org/10.1093/brain/awv081	https://doi.org/10.1093/brain/awv081	PROPN
fnp-3806	4275	2	bolós	bolós	NOUN
fnp-3806	4275	3	m	m	PROPN
fnp-3806	4275	4	,	,	PUNCT
fnp-3806	4275	5	llorens	llorens	PROPN
fnp-3806	4275	6	-	-	PUNCT
fnp-3806	4275	7	martín	martín	NOUN
fnp-3806	4275	8	m	m	PROPN
fnp-3806	4275	9	,	,	PUNCT
fnp-3806	4275	10	jurado	jurado	PROPN
fnp-3806	4275	11	-	-	PUNCT
fnp-3806	4275	12	arjona	arjona	PROPN
fnp-3806	4275	13	j	j	PROPN
fnp-3806	4275	14	,	,	PUNCT
fnp-3806	4275	15	et	et	PROPN
fnp-3806	4275	16	al	al	PROPN
fnp-3806	4275	17	.	.	PUNCT
fnp-3806	4276	1	direct	direct	ADJ
fnp-3806	4276	2	evidence	evidence	NOUN
fnp-3806	4276	3	of	of	ADP
fnp-3806	4276	4	internalization	internalization	NOUN
fnp-3806	4276	5	of	of	ADP
fnp-3806	4276	6	tau	tau	PROPN
fnp-3806	4276	7	by	by	ADP
fnp-3806	4276	8	microglia	microglia	NOUN
fnp-3806	4276	9	in	in	ADP
fnp-3806	4276	10	vitro	vitro	X
fnp-3806	4276	11	and	and	CCONJ
fnp-3806	4276	12	in	in	ADP
fnp-3806	4276	13	vivo	vivo	NOUN
fnp-3806	4276	14	.	.	PUNCT
fnp-3806	4277	1	j	j	PROPN
fnp-3806	4277	2	alzheimers	alzheimers	PROPN
fnp-3806	4277	3	dis	dis	PROPN
fnp-3806	4277	4	2016;50:77	2016;50:77	PROPN
fnp-3806	4277	5	-	-	PUNCT
fnp-3806	4277	6	87	87	NUM
fnp-3806	4277	7	.	.	PUNCT
fnp-3806	4277	8	https://doi.org/10.3233/jad-150704	https://doi.org/10.3233/jad-150704	PROPN
fnp-3806	4277	9	perea	perea	PROPN
fnp-3806	4277	10	jr	jr	PROPN
fnp-3806	4277	11	,	,	PUNCT
fnp-3806	4277	12	llorens	llorens	PROPN
fnp-3806	4277	13	-	-	PUNCT
fnp-3806	4277	14	martín	martín	NOUN
fnp-3806	4277	15	m	m	PROPN
fnp-3806	4277	16	,	,	PUNCT
fnp-3806	4277	17	ávila	ávila	PROPN
fnp-3806	4277	18	j	j	PROPN
fnp-3806	4277	19	,	,	PUNCT
fnp-3806	4277	20	et	et	PROPN
fnp-3806	4277	21	al	al	PROPN
fnp-3806	4277	22	.	.	PUNCT
fnp-3806	4278	1	the	the	DET
fnp-3806	4278	2	role	role	NOUN
fnp-3806	4278	3	of	of	ADP
fnp-3806	4278	4	microglia	microglia	NOUN
fnp-3806	4278	5	in	in	ADP
fnp-3806	4278	6	the	the	DET
fnp-3806	4278	7	spread	spread	NOUN
fnp-3806	4278	8	of	of	ADP
fnp-3806	4278	9	tau	tau	NOUN
fnp-3806	4278	10	:	:	PUNCT
fnp-3806	4278	11	relevance	relevance	NOUN
fnp-3806	4278	12	for	for	ADP
fnp-3806	4278	13	tauopathies	tauopathie	NOUN
fnp-3806	4278	14	.	.	PUNCT
fnp-3806	4279	1	front	front	ADJ
fnp-3806	4279	2	cell	cell	NOUN
fnp-3806	4279	3	neurosci	neurosci	NOUN
fnp-3806	4279	4	2018;12:172	2018;12:172	NUM
fnp-3806	4279	5	.	.	PUNCT
fnp-3806	4280	1	https://doi.org/10.3389/fncel.2018.00172	https://doi.org/10.3389/fncel.2018.00172	PROPN
fnp-3806	4280	2	španić	španić	NOUN
fnp-3806	4280	3	e	e	NOUN
fnp-3806	4280	4	,	,	PUNCT
fnp-3806	4280	5	langer	langer	PROPN
fnp-3806	4280	6	horvat	horvat	NOUN
fnp-3806	4280	7	l	l	PROPN
fnp-3806	4280	8	,	,	PUNCT
fnp-3806	4280	9	hof	hof	PROPN
fnp-3806	4280	10	pr	pr	PROPN
fnp-3806	4280	11	,	,	PUNCT
fnp-3806	4280	12	et	et	PROPN
fnp-3806	4280	13	al	al	PROPN
fnp-3806	4280	14	.	.	PUNCT
fnp-3806	4280	15	role	role	NOUN
fnp-3806	4280	16	of	of	ADP
fnp-3806	4280	17	microglial	microglial	ADJ
fnp-3806	4280	18	cells	cell	NOUN
fnp-3806	4280	19	in	in	ADP
fnp-3806	4280	20	alzheimer	alzheimer	PROPN
fnp-3806	4280	21	's	's	PART
fnp-3806	4280	22	disease	disease	NOUN
fnp-3806	4280	23	tau	tau	PROPN
fnp-3806	4280	24	propagation	propagation	NOUN
fnp-3806	4280	25	.	.	PUNCT
fnp-3806	4281	1	front	front	ADJ
fnp-3806	4281	2	aging	age	VERB
fnp-3806	4281	3	neurosci	neurosci	NOUN
fnp-3806	4281	4	2019;11:271	2019;11:271	NOUN
fnp-3806	4281	5	.	.	PUNCT
fnp-3806	4282	1	https://doi.org/10.3389/fnagi.2019.00271	https://doi.org/10.3389/fnagi.2019.00271	PROPN
fnp-3806	4282	2	brelstaff	brelstaff	NOUN
fnp-3806	4282	3	jh	jh	PROPN
fnp-3806	4282	4	,	,	PUNCT
fnp-3806	4282	5	mason	mason	PROPN
fnp-3806	4282	6	m	m	PROPN
fnp-3806	4282	7	,	,	PUNCT
fnp-3806	4282	8	katsinelos	katsinelos	PROPN
fnp-3806	4282	9	t	t	PROPN
fnp-3806	4282	10	,	,	PUNCT
fnp-3806	4282	11	et	et	PROPN
fnp-3806	4282	12	al	al	PROPN
fnp-3806	4282	13	.	.	PUNCT
fnp-3806	4283	1	microglia	microglia	PROPN
fnp-3806	4283	2	become	become	VERB
fnp-3806	4283	3	hypofunctional	hypofunctional	ADJ
fnp-3806	4283	4	and	and	CCONJ
fnp-3806	4283	5	release	release	VERB
fnp-3806	4283	6	metalloproteases	metalloprotease	NOUN
fnp-3806	4283	7	and	and	CCONJ
fnp-3806	4283	8	tau	tau	PROPN
fnp-3806	4283	9	seeds	seed	NOUN
fnp-3806	4283	10	when	when	SCONJ
fnp-3806	4283	11	phagocytosing	phagocytose	VERB
fnp-3806	4283	12	live	live	ADJ
fnp-3806	4283	13	neurons	neuron	NOUN
fnp-3806	4283	14	with	with	ADP
fnp-3806	4283	15	p301s	p301s	PROPN
fnp-3806	4283	16	tau	tau	PROPN
fnp-3806	4283	17	aggregates	aggregate	VERB
fnp-3806	4283	18	.	.	PUNCT
fnp-3806	4284	1	sci	sci	PROPN
fnp-3806	4284	2	adv	adv	PROPN
fnp-3806	4284	3	2021;7	2021;7	PROPN
fnp-3806	4284	4	:	:	PUNCT
fnp-3806	4284	5	eabg4980	eabg4980	PROPN
fnp-3806	4284	6	.	.	PUNCT
fnp-3806	4285	1	https://doi.org/10.1126/sciadv.abg4980	https://doi.org/10.1126/sciadv.abg4980	PROPN
fnp-3806	4285	2	gratuze	gratuze	PROPN
fnp-3806	4285	3	m	m	PROPN
fnp-3806	4285	4	,	,	PUNCT
fnp-3806	4285	5	chen	chen	PROPN
fnp-3806	4285	6	y	y	PROPN
fnp-3806	4285	7	,	,	PUNCT
fnp-3806	4285	8	parhizkar	parhizkar	PROPN
fnp-3806	4285	9	s	s	PROPN
fnp-3806	4285	10	,	,	PUNCT
fnp-3806	4285	11	et	et	PROPN
fnp-3806	4285	12	al	al	PROPN
fnp-3806	4285	13	.	.	PROPN
fnp-3806	4285	14	activated	activate	VERB
fnp-3806	4285	15	microglia	microglia	ADJ
fnp-3806	4285	16	mitigate	mitigate	NOUN
fnp-3806	4285	17	aβ	aβ	NOUN
fnp-3806	4285	18	-	-	PUNCT
fnp-3806	4285	19	associated	associate	VERB
fnp-3806	4285	20	tau	tau	NOUN
fnp-3806	4285	21	seeding	seed	VERB
fnp-3806	4285	22	and	and	CCONJ
fnp-3806	4285	23	spreading	spread	VERB
fnp-3806	4285	24	.	.	PUNCT
fnp-3806	4286	1	j	j	PROPN
fnp-3806	4286	2	exp	exp	NOUN
fnp-3806	4286	3	med	med	PROPN
fnp-3806	4286	4	2021;218	2021;218	NOUN
fnp-3806	4286	5	:	:	PUNCT
fnp-3806	4286	6	e20210542	e20210542	PROPN
fnp-3806	4286	7	.	.	PUNCT
fnp-3806	4287	1	https://doi.org/10.1084/jem.20210542	https://doi.org/10.1084/jem.20210542	PROPN
fnp-3806	4287	2	hopp	hopp	PROPN
fnp-3806	4287	3	sc	sc	PROPN
fnp-3806	4287	4	,	,	PUNCT
fnp-3806	4287	5	lin	lin	PROPN
fnp-3806	4287	6	y	y	PROPN
fnp-3806	4287	7	,	,	PUNCT
fnp-3806	4287	8	oakley	oakley	PROPN
fnp-3806	4287	9	d	d	PROPN
fnp-3806	4287	10	,	,	PUNCT
fnp-3806	4287	11	et	et	PROPN
fnp-3806	4287	12	al	al	PROPN
fnp-3806	4287	13	.	.	PUNCT
fnp-3806	4288	1	the	the	DET
fnp-3806	4288	2	role	role	NOUN
fnp-3806	4288	3	of	of	ADP
fnp-3806	4288	4	microglia	microglia	NOUN
fnp-3806	4288	5	in	in	ADP
fnp-3806	4288	6	processing	processing	NOUN
fnp-3806	4288	7	and	and	CCONJ
fnp-3806	4288	8	spreading	spread	VERB
fnp-3806	4288	9	of	of	ADP
fnp-3806	4288	10	bioactive	bioactive	PROPN
fnp-3806	4288	11	tau	tau	PROPN
fnp-3806	4288	12	seeds	seed	NOUN
fnp-3806	4288	13	in	in	ADP
fnp-3806	4288	14	alzheimer	alzheimer	PROPN
fnp-3806	4288	15	's	's	PART
fnp-3806	4288	16	disease	disease	NOUN
fnp-3806	4288	17	.	.	PUNCT
fnp-3806	4289	1	j	j	PROPN
fnp-3806	4289	2	neuroinflammation	neuroinflammation	PROPN
fnp-3806	4289	3	2018;15:269	2018;15:269	NOUN
fnp-3806	4289	4	.	.	PUNCT
fnp-3806	4290	1	https://doi.org/10.1186/s12974-018-1309-z	https://doi.org/10.1186/s12974-018-1309-z	PROPN
fnp-3806	4290	2	jellinger	jellinger	PROPN
fnp-3806	4290	3	ka	ka	PROPN
fnp-3806	4290	4	,	,	PUNCT
fnp-3806	4290	5	stadelmann	stadelmann	PROPN
fnp-3806	4290	6	c.	c.	PROPN
fnp-3806	4290	7	problems	problem	NOUN
fnp-3806	4290	8	of	of	ADP
fnp-3806	4290	9	cell	cell	NOUN
fnp-3806	4290	10	death	death	NOUN
fnp-3806	4290	11	in	in	ADP
fnp-3806	4290	12	neurodegeneration	neurodegeneration	NOUN
fnp-3806	4290	13	and	and	CCONJ
fnp-3806	4290	14	alzheimer	alzheimer	NOUN
fnp-3806	4290	15	's	's	PART
fnp-3806	4290	16	disease	disease	NOUN
fnp-3806	4290	17	.	.	PUNCT
fnp-3806	4291	1	j	j	PROPN
fnp-3806	4291	2	alzheimers	alzheimers	PROPN
fnp-3806	4291	3	dis	dis	PROPN
fnp-3806	4291	4	2001;3:31	2001;3:31	PROPN
fnp-3806	4291	5	-	-	PUNCT
fnp-3806	4291	6	40	40	NUM
fnp-3806	4291	7	.	.	PUNCT
fnp-3806	4292	1	https://doi.org/10.3233/jad-2001-3106	https://doi.org/10.3233/jad-2001-3106	PROPN
fnp-3806	4292	2	roth	roth	PROPN
fnp-3806	4292	3	ka	ka	PROPN
fnp-3806	4292	4	.	.	PROPN
fnp-3806	4292	5	caspases	caspases	PROPN
fnp-3806	4292	6	,	,	PUNCT
fnp-3806	4292	7	apoptosis	apoptosis	NOUN
fnp-3806	4292	8	,	,	PUNCT
fnp-3806	4292	9	and	and	CCONJ
fnp-3806	4292	10	alzheimer	alzheimer	PROPN
fnp-3806	4292	11	disease	disease	NOUN
fnp-3806	4292	12	:	:	PUNCT
fnp-3806	4292	13	causation	causation	NOUN
fnp-3806	4292	14	,	,	PUNCT
fnp-3806	4292	15	correlation	correlation	NOUN
fnp-3806	4292	16	,	,	PUNCT
fnp-3806	4292	17	and	and	CCONJ
fnp-3806	4292	18	confusion	confusion	NOUN
fnp-3806	4292	19	.	.	PUNCT
fnp-3806	4293	1	j	j	PROPN
fnp-3806	4293	2	neuropathol	neuropathol	PROPN
fnp-3806	4293	3	exp	exp	PROPN
fnp-3806	4293	4	neurol	neurol	PROPN
fnp-3806	4293	5	2001;60:829	2001;60:829	PROPN
fnp-3806	4293	6	-	-	PUNCT
fnp-3806	4293	7	838	838	NUM
fnp-3806	4293	8	.	.	PUNCT
fnp-3806	4294	1	https://doi.org/10.1093/jnen/60.9.829	https://doi.org/10.1093/jnen/60.9.829	PROPN
fnp-3806	4294	2	obulesu	obulesu	PROPN
fnp-3806	4294	3	m	m	PROPN
fnp-3806	4294	4	,	,	PUNCT
fnp-3806	4294	5	lakshmi	lakshmi	PROPN
fnp-3806	4294	6	mj	mj	PROPN
fnp-3806	4294	7	.	.	PUNCT
fnp-3806	4294	8	apoptosis	apoptosis	PROPN
fnp-3806	4294	9	in	in	ADP
fnp-3806	4294	10	alzheimer	alzheimer	PROPN
fnp-3806	4294	11	's	's	PART
fnp-3806	4294	12	disease	disease	NOUN
fnp-3806	4294	13	:	:	PUNCT
fnp-3806	4294	14	an	an	DET
fnp-3806	4294	15	understanding	understanding	NOUN
fnp-3806	4294	16	of	of	ADP
fnp-3806	4294	17	the	the	DET
fnp-3806	4294	18	physiology	physiology	NOUN
fnp-3806	4294	19	,	,	PUNCT
fnp-3806	4294	20	pathology	pathology	NOUN
fnp-3806	4294	21	and	and	CCONJ
fnp-3806	4294	22	therapeutic	therapeutic	ADJ
fnp-3806	4294	23	avenues	avenue	NOUN
fnp-3806	4294	24	.	.	PUNCT
fnp-3806	4295	1	neurochem	neurochem	PROPN
fnp-3806	4295	2	res	re	VERB
fnp-3806	4295	3	2014;39:2301	2014;39:2301	NUM
fnp-3806	4295	4	-	-	SYM
fnp-3806	4295	5	2312	2312	NUM
fnp-3806	4295	6	.	.	PUNCT
fnp-3806	4296	1	https://doi.org/10.1007/s11064-014-1454-4	https://doi.org/10.1007/s11064-014-1454-4	PROPN
fnp-3806	4296	2	fasulo	fasulo	PROPN
fnp-3806	4296	3	l	l	PROPN
fnp-3806	4296	4	,	,	PUNCT
fnp-3806	4296	5	ugolini	ugolini	NOUN
fnp-3806	4296	6	g	g	PROPN
fnp-3806	4296	7	,	,	PUNCT
fnp-3806	4296	8	visintin	visintin	PROPN
fnp-3806	4296	9	m	m	PROPN
fnp-3806	4296	10	,	,	PUNCT
fnp-3806	4296	11	et	et	PROPN
fnp-3806	4296	12	al	al	PROPN
fnp-3806	4296	13	.	.	PUNCT
fnp-3806	4297	1	the	the	DET
fnp-3806	4297	2	neuronal	neuronal	ADJ
fnp-3806	4297	3	microtubule	microtubule	NOUN
fnp-3806	4297	4	-	-	PUNCT
fnp-3806	4297	5	associated	associate	VERB
fnp-3806	4297	6	protein	protein	NOUN
fnp-3806	4297	7	tau	tau	PROPN
fnp-3806	4297	8	is	be	AUX
fnp-3806	4297	9	a	a	DET
fnp-3806	4297	10	substrate	substrate	NOUN
fnp-3806	4297	11	for	for	ADP
fnp-3806	4297	12	caspase-3	caspase-3	NUM
fnp-3806	4297	13	and	and	CCONJ
fnp-3806	4297	14	an	an	DET
fnp-3806	4297	15	effector	effector	NOUN
fnp-3806	4297	16	of	of	ADP
fnp-3806	4297	17	apoptosis	apoptosis	NOUN
fnp-3806	4297	18	.	.	PUNCT
fnp-3806	4298	1	j	j	PROPN
fnp-3806	4298	2	neurochem	neurochem	PROPN
fnp-3806	4298	3	2000;75:624	2000;75:624	PROPN
fnp-3806	4298	4	-	-	PUNCT
fnp-3806	4298	5	633	633	NUM
fnp-3806	4298	6	.	.	PUNCT
fnp-3806	4299	1	https://doi.org/10.1046/j.1471-4159.2000.0750624.x	https://doi.org/10.1046/j.1471-4159.2000.0750624.x	ADJ
fnp-3806	4299	2	chung	chung	PROPN
fnp-3806	4299	3	cw	cw	PROPN
fnp-3806	4299	4	,	,	PUNCT
fnp-3806	4299	5	song	song	NOUN
fnp-3806	4299	6	yh	yh	PROPN
fnp-3806	4299	7	,	,	PUNCT
fnp-3806	4299	8	kim	kim	PROPN
fnp-3806	4299	9	kk	kk	PROPN
fnp-3806	4299	10	,	,	PUNCT
fnp-3806	4299	11	et	et	PROPN
fnp-3806	4299	12	al	al	PROPN
fnp-3806	4299	13	.	.	PROPN
fnp-3806	4299	14	proapoptotic	proapoptotic	ADJ
fnp-3806	4299	15	effects	effect	NOUN
fnp-3806	4299	16	of	of	ADP
fnp-3806	4299	17	tau	tau	PROPN
fnp-3806	4299	18	cleavage	cleavage	NOUN
fnp-3806	4299	19	product	product	NOUN
fnp-3806	4299	20	generated	generate	VERB
fnp-3806	4299	21	by	by	ADP
fnp-3806	4299	22	caspase-3	caspase-3	PROPN
fnp-3806	4299	23	.	.	PUNCT
fnp-3806	4299	24	neurobiol	neurobiol	PROPN
fnp-3806	4299	25	dis	dis	PROPN
fnp-3806	4299	26	2001;8:162	2001;8:162	PROPN
fnp-3806	4299	27	-	-	PROPN
fnp-3806	4299	28	172	172	NUM
fnp-3806	4299	29	.	.	PUNCT
fnp-3806	4300	1	https://doi.org/10.1006/nbdi.2000.0335	https://doi.org/10.1006/nbdi.2000.0335	PROPN
fnp-3806	4300	2	zilkova	zilkova	PROPN
fnp-3806	4300	3	m	m	PROPN
fnp-3806	4300	4	,	,	PUNCT
fnp-3806	4300	5	zilka	zilka	PROPN
fnp-3806	4300	6	n	n	CCONJ
fnp-3806	4300	7	,	,	PUNCT
fnp-3806	4300	8	kovac	kovac	PROPN
fnp-3806	4300	9	a	a	PROPN
fnp-3806	4300	10	,	,	PUNCT
fnp-3806	4300	11	et	et	PROPN
fnp-3806	4300	12	al	al	PROPN
fnp-3806	4300	13	.	.	PROPN
fnp-3806	4300	14	hyperphosphorylated	hyperphosphorylated	PROPN
fnp-3806	4300	15	truncated	truncate	VERB
fnp-3806	4300	16	protein	protein	NOUN
fnp-3806	4300	17	tau	tau	PROPN
fnp-3806	4300	18	induces	induce	VERB
fnp-3806	4300	19	caspase-3	caspase-3	NUM
fnp-3806	4300	20	independent	independent	ADJ
fnp-3806	4300	21	apoptosis	apoptosis	NOUN
fnp-3806	4300	22	-	-	PUNCT
fnp-3806	4300	23	like	like	ADJ
fnp-3806	4300	24	pathway	pathway	NOUN
fnp-3806	4300	25	in	in	ADP
fnp-3806	4300	26	the	the	DET
fnp-3806	4300	27	alzheimer	alzheimer	NOUN
fnp-3806	4300	28	's	's	PART
fnp-3806	4300	29	disease	disease	NOUN
fnp-3806	4300	30	cellular	cellular	ADJ
fnp-3806	4300	31	model	model	NOUN
fnp-3806	4300	32	.	.	PUNCT
fnp-3806	4301	1	alzheimers	alzheimers	PROPN
fnp-3806	4301	2	dis	dis	PROPN
fnp-3806	4301	3	2011;23:161	2011;23:161	NUM
fnp-3806	4301	4	-	-	SYM
fnp-3806	4301	5	169	169	NUM
fnp-3806	4301	6	.	.	PUNCT
fnp-3806	4302	1	https://doi.org/10.3233/jad-2010-101434	https://doi.org/10.3233/jad-2010-101434	PROPN
fnp-3806	4302	2	gómez	gómez	PROPN
fnp-3806	4302	3	-	-	PUNCT
fnp-3806	4302	4	ramos	ramos	PROPN
fnp-3806	4302	5	a	a	DET
fnp-3806	4302	6	,	,	PUNCT
fnp-3806	4302	7	díaz	díaz	NOUN
fnp-3806	4302	8	-	-	PUNCT
fnp-3806	4302	9	hernández	hernández	NOUN
fnp-3806	4302	10	m	m	PROPN
fnp-3806	4302	11	,	,	PUNCT
fnp-3806	4302	12	cuadros	cuadros	PROPN
fnp-3806	4302	13	r	r	PROPN
fnp-3806	4302	14	,	,	PUNCT
fnp-3806	4302	15	et	et	PROPN
fnp-3806	4302	16	al	al	PROPN
fnp-3806	4302	17	.	.	PROPN
fnp-3806	4303	1	extracellular	extracellular	PROPN
fnp-3806	4303	2	tau	tau	PROPN
fnp-3806	4303	3	is	be	AUX
fnp-3806	4303	4	toxic	toxic	ADJ
fnp-3806	4303	5	to	to	ADP
fnp-3806	4303	6	neuronal	neuronal	ADJ
fnp-3806	4303	7	cells	cell	NOUN
fnp-3806	4303	8	.	.	PUNCT
fnp-3806	4304	1	febs	febs	PROPN
fnp-3806	4304	2	lett	lett	PROPN
fnp-3806	4304	3	2006;580:4842	2006;580:4842	PROPN
fnp-3806	4304	4	-	-	SYM
fnp-3806	4304	5	4850	4850	NUM
fnp-3806	4304	6	.	.	PUNCT
fnp-3806	4305	1	https://doi.org/10.1016/j.febslet.2006.07.078	https://doi.org/10.1016/j.febslet.2006.07.078	VERB
fnp-3806	4305	2	caccamo	caccamo	VERB
fnp-3806	4305	3	a	a	DET
fnp-3806	4305	4	,	,	PUNCT
fnp-3806	4305	5	branca	branca	NOUN
fnp-3806	4305	6	c	c	NOUN
fnp-3806	4305	7	,	,	PUNCT
fnp-3806	4305	8	piras	piras	PROPN
fnp-3806	4305	9	is	be	AUX
fnp-3806	4305	10	,	,	PUNCT
fnp-3806	4305	11	et	et	PROPN
fnp-3806	4305	12	al	al	PROPN
fnp-3806	4305	13	.	.	PROPN
fnp-3806	4305	14	necroptosis	necroptosis	NOUN
fnp-3806	4305	15	activation	activation	NOUN
fnp-3806	4305	16	in	in	ADP
fnp-3806	4305	17	alzheimer	alzheimer	PROPN
fnp-3806	4305	18	's	's	PART
fnp-3806	4305	19	disease	disease	NOUN
fnp-3806	4305	20	.	.	PUNCT
fnp-3806	4306	1	nat	nat	PROPN
fnp-3806	4306	2	neurosci	neurosci	PROPN
fnp-3806	4306	3	2017;20:1236	2017;20:1236	NUM
fnp-3806	4306	4	-	-	SYM
fnp-3806	4306	5	1246	1246	NUM
fnp-3806	4306	6	.	.	PUNCT
fnp-3806	4307	1	https://doi.org/10.1038/nn.4608	https://doi.org/10.1038/nn.4608	PROPN
fnp-3806	4307	2	royce	royce	PROPN
fnp-3806	4307	3	gh	gh	PROPN
fnp-3806	4307	4	,	,	PUNCT
fnp-3806	4307	5	brown	brown	PROPN
fnp-3806	4307	6	-	-	PUNCT
fnp-3806	4307	7	borg	borg	PROPN
fnp-3806	4307	8	hm	hm	PROPN
fnp-3806	4307	9	,	,	PUNCT
fnp-3806	4307	10	deepa	deepa	PROPN
fnp-3806	4307	11	ss	ss	PROPN
fnp-3806	4307	12	.	.	PUNCT
fnp-3806	4308	1	the	the	DET
fnp-3806	4308	2	potential	potential	ADJ
fnp-3806	4308	3	role	role	NOUN
fnp-3806	4308	4	of	of	ADP
fnp-3806	4308	5	necroptosis	necroptosis	NOUN
fnp-3806	4308	6	in	in	ADP
fnp-3806	4308	7	inflammaging	inflammage	VERB
fnp-3806	4308	8	and	and	CCONJ
fnp-3806	4308	9	aging	aging	NOUN
fnp-3806	4308	10	.	.	PUNCT
fnp-3806	4309	1	geroscience	geroscience	NOUN
fnp-3806	4309	2	2019;41:795	2019;41:795	NUM
fnp-3806	4309	3	-	-	SYM
fnp-3806	4309	4	811	811	NUM
fnp-3806	4309	5	.	.	PUNCT
fnp-3806	4310	1	https://doi.org/10.1007/s11357-019-00131-w	https://doi.org/10.1007/s11357-019-00131-w	NOUN
fnp-3806	4310	2	dionísio	dionísio	ADJ
fnp-3806	4310	3	pa	pa	PROPN
fnp-3806	4310	4	,	,	PUNCT
fnp-3806	4310	5	amaral	amaral	PROPN
fnp-3806	4310	6	jd	jd	PROPN
fnp-3806	4310	7	,	,	PUNCT
fnp-3806	4310	8	rodrigues	rodrigues	PROPN
fnp-3806	4310	9	cmp	cmp	PROPN
fnp-3806	4310	10	.	.	PUNCT
fnp-3806	4311	1	molecular	molecular	ADJ
fnp-3806	4311	2	mechanisms	mechanism	NOUN
fnp-3806	4311	3	of	of	ADP
fnp-3806	4311	4	necroptosis	necroptosis	NOUN
fnp-3806	4311	5	and	and	CCONJ
fnp-3806	4311	6	relevance	relevance	NOUN
fnp-3806	4311	7	for	for	ADP
fnp-3806	4311	8	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4311	9	diseases	disease	NOUN
fnp-3806	4311	10	.	.	PUNCT
fnp-3806	4312	1	int	int	PROPN
fnp-3806	4312	2	rev	rev	PROPN
fnp-3806	4312	3	cell	cell	NOUN
fnp-3806	4312	4	mol	mol	ADP
fnp-3806	4312	5	biol	biol	PROPN
fnp-3806	4312	6	2020;353:31	2020;353:31	NUM
fnp-3806	4312	7	-	-	SYM
fnp-3806	4312	8	82	82	NUM
fnp-3806	4312	9	.	.	PUNCT
fnp-3806	4313	1	https://doi.org/10.1016/bs.ircmb.2019.12.006	https://doi.org/10.1016/bs.ircmb.2019.12.006	X
fnp-3806	4313	2	gómez	gómez	PROPN
fnp-3806	4313	3	-	-	PUNCT
fnp-3806	4313	4	isla	isla	PROPN
fnp-3806	4313	5	t	t	PROPN
fnp-3806	4313	6	,	,	PUNCT
fnp-3806	4313	7	hollister	hollister	PROPN
fnp-3806	4313	8	r	r	PROPN
fnp-3806	4313	9	,	,	PUNCT
fnp-3806	4313	10	west	west	NOUN
fnp-3806	4313	11	h	h	NOUN
fnp-3806	4313	12	,	,	PUNCT
fnp-3806	4313	13	et	et	PROPN
fnp-3806	4313	14	al	al	PROPN
fnp-3806	4313	15	.	.	PUNCT
fnp-3806	4314	1	neuronal	neuronal	ADJ
fnp-3806	4314	2	loss	loss	NOUN
fnp-3806	4314	3	correlates	correlate	VERB
fnp-3806	4314	4	with	with	ADP
fnp-3806	4314	5	but	but	CCONJ
fnp-3806	4314	6	exceeds	exceed	VERB
fnp-3806	4314	7	neurofibrillary	neurofibrillary	ADJ
fnp-3806	4314	8	tangles	tangle	NOUN
fnp-3806	4314	9	in	in	ADP
fnp-3806	4314	10	alzheimer	alzheimer	PROPN
fnp-3806	4314	11	's	's	PART
fnp-3806	4314	12	disease	disease	NOUN
fnp-3806	4314	13	.	.	PUNCT
fnp-3806	4315	1	ann	ann	PROPN
fnp-3806	4315	2	neurol	neurol	PROPN
fnp-3806	4315	3	1997;41:17	1997;41:17	NUM
fnp-3806	4315	4	-	-	SYM
fnp-3806	4315	5	24	24	NUM
fnp-3806	4315	6	.	.	PUNCT
fnp-3806	4316	1	https://doi.org/10.1002/ana.410410106	https://doi.org/10.1002/ana.410410106	PROPN
fnp-3806	4316	2	van	van	PROPN
fnp-3806	4316	3	de	de	PROPN
fnp-3806	4316	4	nes	nes	PROPN
fnp-3806	4316	5	jap	jap	PROPN
fnp-3806	4316	6	,	,	PUNCT
fnp-3806	4316	7	nafe	nafe	ADJ
fnp-3806	4316	8	r	r	NOUN
fnp-3806	4316	9	,	,	PUNCT
fnp-3806	4316	10	schlote	schlote	VERB
fnp-3806	4316	11	w.	w.	PROPN
fnp-3806	4316	12	non	non	PROPN
fnp-3806	4316	13	-	-	ADJ
fnp-3806	4316	14	tau	tau	ADJ
fnp-3806	4316	15	based	base	VERB
fnp-3806	4316	16	neuronal	neuronal	ADJ
fnp-3806	4316	17	degeneration	degeneration	NOUN
fnp-3806	4316	18	in	in	ADP
fnp-3806	4316	19	alzheimer	alzheimer	PROPN
fnp-3806	4316	20	's	's	PART
fnp-3806	4316	21	disease	disease	NOUN
fnp-3806	4316	22	-an	-an	ADP
fnp-3806	4316	23	immunocytochemical	immunocytochemical	ADJ
fnp-3806	4316	24	and	and	CCONJ
fnp-3806	4316	25	quantitative	quantitative	ADJ
fnp-3806	4316	26	study	study	NOUN
fnp-3806	4316	27	in	in	ADP
fnp-3806	4316	28	the	the	DET
fnp-3806	4316	29	supragranular	supragranular	ADJ
fnp-3806	4316	30	layers	layer	NOUN
fnp-3806	4316	31	of	of	ADP
fnp-3806	4316	32	the	the	DET
fnp-3806	4316	33	middle	middle	ADJ
fnp-3806	4316	34	temporal	temporal	ADJ
fnp-3806	4316	35	neocortex	neocortex	NOUN
fnp-3806	4316	36	.	.	PUNCT
fnp-3806	4317	1	brain	brain	NOUN
fnp-3806	4317	2	res	re	NOUN
fnp-3806	4317	3	2008;1213:152	2008;1213:152	NUM
fnp-3806	4317	4	-	-	SYM
fnp-3806	4317	5	165	165	NUM
fnp-3806	4317	6	.	.	PUNCT
fnp-3806	4318	1	https://doi.org/10.1016/j.brainres.2008.03.043	https://doi.org/10.1016/j.brainres.2008.03.043	NOUN
fnp-3806	4318	2	takahashi	takahashi	PROPN
fnp-3806	4318	3	rh	rh	PROPN
fnp-3806	4318	4	,	,	PUNCT
fnp-3806	4318	5	nagao	nagao	ADJ
fnp-3806	4318	6	t	t	PROPN
fnp-3806	4318	7	,	,	PUNCT
fnp-3806	4318	8	gouras	gouras	X
fnp-3806	4318	9	gk	gk	PROPN
fnp-3806	4318	10	.	.	PROPN
fnp-3806	4318	11	plaque	plaque	NOUN
fnp-3806	4318	12	formation	formation	NOUN
fnp-3806	4318	13	and	and	CCONJ
fnp-3806	4318	14	the	the	DET
fnp-3806	4318	15	intraneuronal	intraneuronal	ADJ
fnp-3806	4318	16	accumulation	accumulation	NOUN
fnp-3806	4318	17	of	of	ADP
fnp-3806	4318	18	β	β	NOUN
fnp-3806	4318	19	-	-	NOUN
fnp-3806	4318	20	amyloid	amyloid	NOUN
fnp-3806	4318	21	in	in	ADP
fnp-3806	4318	22	alzheimer	alzheimer	PROPN
fnp-3806	4318	23	's	's	PART
fnp-3806	4318	24	disease	disease	NOUN
fnp-3806	4318	25	.	.	PUNCT
fnp-3806	4319	1	pathol	pathol	VERB
fnp-3806	4319	2	int	int	NOUN
fnp-3806	4319	3	2017;67:185	2017;67:185	NOUN
fnp-3806	4319	4	-	-	SYM
fnp-3806	4319	5	193	193	NUM
fnp-3806	4319	6	.	.	PUNCT
fnp-3806	4320	1	https://doi.org/10.1111/pin.12520	https://doi.org/10.1111/pin.12520	NOUN
fnp-3806	4320	2	jeong	jeong	PROPN
fnp-3806	4320	3	s.	s.	PROPN
fnp-3806	4320	4	molecular	molecular	ADJ
fnp-3806	4320	5	and	and	CCONJ
fnp-3806	4320	6	cellular	cellular	ADJ
fnp-3806	4320	7	basis	basis	NOUN
fnp-3806	4320	8	of	of	ADP
fnp-3806	4320	9	neurodegeneration	neurodegeneration	NOUN
fnp-3806	4320	10	in	in	ADP
fnp-3806	4320	11	alzheimer	alzheimer	PROPN
fnp-3806	4320	12	's	's	PART
fnp-3806	4320	13	disease	disease	NOUN
fnp-3806	4320	14	.	.	PUNCT
fnp-3806	4321	1	mol	mol	ADP
fnp-3806	4321	2	cells	cell	NOUN
fnp-3806	4321	3	2017;40:613	2017;40:613	PROPN
fnp-3806	4321	4	-	-	SYM
fnp-3806	4321	5	620	620	NUM
fnp-3806	4321	6	.	.	PUNCT
fnp-3806	4322	1	https://doi.org/10.14348/molcells.2017.0096	https://doi.org/10.14348/molcells.2017.0096	PROPN
fnp-3806	4322	2	leong	leong	PROPN
fnp-3806	4322	3	yq	yq	PROPN
fnp-3806	4322	4	,	,	PUNCT
fnp-3806	4322	5	ng	ng	PROPN
fnp-3806	4322	6	ky	ky	PROPN
fnp-3806	4322	7	,	,	PUNCT
fnp-3806	4322	8	chye	chye	PROPN
fnp-3806	4322	9	sm	sm	PROPN
fnp-3806	4322	10	,	,	PUNCT
fnp-3806	4322	11	et	et	PROPN
fnp-3806	4322	12	al	al	PROPN
fnp-3806	4322	13	.	.	PROPN
fnp-3806	4322	14	mechanisms	mechanism	NOUN
fnp-3806	4322	15	of	of	ADP
fnp-3806	4322	16	action	action	NOUN
fnp-3806	4322	17	of	of	ADP
fnp-3806	4322	18	amyloid	amyloid	NOUN
fnp-3806	4322	19	-	-	PUNCT
fnp-3806	4322	20	beta	beta	NOUN
fnp-3806	4322	21	and	and	CCONJ
fnp-3806	4322	22	its	its	PRON
fnp-3806	4322	23	precursor	precursor	NOUN
fnp-3806	4322	24	protein	protein	NOUN
fnp-3806	4322	25	in	in	ADP
fnp-3806	4322	26	neuronal	neuronal	ADJ
fnp-3806	4322	27	cell	cell	NOUN
fnp-3806	4322	28	death	death	NOUN
fnp-3806	4322	29	.	.	PUNCT
fnp-3806	4323	1	metab	metab	ADJ
fnp-3806	4323	2	brain	brain	NOUN
fnp-3806	4323	3	dis	dis	PROPN
fnp-3806	4323	4	2020;35:11	2020;35:11	NUM
fnp-3806	4323	5	-	-	SYM
fnp-3806	4323	6	30	30	NUM
fnp-3806	4323	7	.	.	PUNCT
fnp-3806	4324	1	https://doi.org/10.1007/s11011-019-00516-y	https://doi.org/10.1007/s11011-019-00516-y	PROPN
fnp-3806	4324	2	siman	siman	PROPN
fnp-3806	4324	3	-	-	PUNCT
fnp-3806	4324	4	tov	tov	PROPN
fnp-3806	4324	5	t	t	PROPN
fnp-3806	4324	6	,	,	PUNCT
fnp-3806	4324	7	bosak	bosak	ADJ
fnp-3806	4324	8	n	n	CCONJ
fnp-3806	4324	9	,	,	PUNCT
fnp-3806	4324	10	sprecher	sprecher	PROPN
fnp-3806	4324	11	e	e	PROPN
fnp-3806	4324	12	,	,	PUNCT
fnp-3806	4324	13	et	et	PROPN
fnp-3806	4324	14	al	al	PROPN
fnp-3806	4324	15	.	.	PUNCT
fnp-3806	4325	1	early	early	ADJ
fnp-3806	4325	2	age	age	NOUN
fnp-3806	4325	3	-	-	PUNCT
fnp-3806	4325	4	related	relate	VERB
fnp-3806	4325	5	functional	functional	ADJ
fnp-3806	4325	6	connectivity	connectivity	NOUN
fnp-3806	4325	7	decline	decline	NOUN
fnp-3806	4325	8	in	in	ADP
fnp-3806	4325	9	high	high	ADJ
fnp-3806	4325	10	-	-	PUNCT
fnp-3806	4325	11	order	order	NOUN
fnp-3806	4325	12	cognitive	cognitive	ADJ
fnp-3806	4325	13	networks	network	NOUN
fnp-3806	4325	14	.	.	PUNCT
fnp-3806	4326	1	front	front	ADJ
fnp-3806	4326	2	aging	age	VERB
fnp-3806	4326	3	neurosci	neurosci	NOUN
fnp-3806	4326	4	2017;8:330	2017;8:330	PROPN
fnp-3806	4326	5	.	.	PUNCT
fnp-3806	4327	1	https://doi.org/10.3389/fnagi.2016.00330	https://doi.org/10.3389/fnagi.2016.00330	PROPN
fnp-3806	4327	2	tsvetanov	tsvetanov	PROPN
fnp-3806	4327	3	ka	ka	PROPN
fnp-3806	4327	4	,	,	PUNCT
fnp-3806	4327	5	henson	henson	PROPN
fnp-3806	4327	6	rn	rn	PROPN
fnp-3806	4327	7	,	,	PUNCT
fnp-3806	4327	8	tyler	tyler	PROPN
fnp-3806	4327	9	lk	lk	PROPN
fnp-3806	4327	10	,	,	PUNCT
fnp-3806	4327	11	et	et	PROPN
fnp-3806	4327	12	al	al	PROPN
fnp-3806	4327	13	.	.	PROPN
fnp-3806	4327	14	extrinsic	extrinsic	ADJ
fnp-3806	4327	15	and	and	CCONJ
fnp-3806	4327	16	intrinsic	intrinsic	ADJ
fnp-3806	4327	17	brain	brain	NOUN
fnp-3806	4327	18	network	network	NOUN
fnp-3806	4327	19	connectivity	connectivity	NOUN
fnp-3806	4327	20	maintains	maintain	VERB
fnp-3806	4327	21	cognition	cognition	NOUN
fnp-3806	4327	22	across	across	ADP
fnp-3806	4327	23	the	the	DET
fnp-3806	4327	24	lifespan	lifespan	NOUN
fnp-3806	4327	25	despite	despite	SCONJ
fnp-3806	4327	26	accelerated	accelerate	VERB
fnp-3806	4327	27	decay	decay	NOUN
fnp-3806	4327	28	of	of	ADP
fnp-3806	4327	29	regional	regional	ADJ
fnp-3806	4327	30	brain	brain	NOUN
fnp-3806	4327	31	activation	activation	NOUN
fnp-3806	4327	32	.	.	PUNCT
fnp-3806	4328	1	j	j	PROPN
fnp-3806	4328	2	neurosci	neurosci	PROPN
fnp-3806	4328	3	2016;36:3115	2016;36:3115	PROPN
fnp-3806	4328	4	-	-	SYM
fnp-3806	4328	5	3126	3126	NUM
fnp-3806	4328	6	.	.	PUNCT
fnp-3806	4329	1	https://doi.org/10.1523/jneurosci.2733-15.2016	https://doi.org/10.1523/jneurosci.2733-15.2016	PROPN
fnp-3806	4329	2	buckley	buckley	NOUN
fnp-3806	4329	3	rf	rf	PROPN
fnp-3806	4329	4	,	,	PUNCT
fnp-3806	4329	5	schultz	schultz	PROPN
fnp-3806	4329	6	ap	ap	PROPN
fnp-3806	4329	7	,	,	PUNCT
fnp-3806	4329	8	hedden	hedden	PROPN
fnp-3806	4329	9	t	t	PROPN
fnp-3806	4329	10	,	,	PUNCT
fnp-3806	4329	11	et	et	PROPN
fnp-3806	4329	12	al	al	PROPN
fnp-3806	4329	13	.	.	PROPN
fnp-3806	4330	1	functional	functional	ADJ
fnp-3806	4330	2	network	network	NOUN
fnp-3806	4330	3	integrity	integrity	NOUN
fnp-3806	4330	4	presages	presage	VERB
fnp-3806	4330	5	cognitive	cognitive	ADJ
fnp-3806	4330	6	decline	decline	NOUN
fnp-3806	4330	7	in	in	ADP
fnp-3806	4330	8	preclinical	preclinical	ADJ
fnp-3806	4330	9	alzheimer	alzheimer	NOUN
fnp-3806	4330	10	disease	disease	PROPN
fnp-3806	4330	11	.	.	PUNCT
fnp-3806	4331	1	neurology	neurology	NOUN
fnp-3806	4331	2	2017;89:29	2017;89:29	NUM
fnp-3806	4331	3	-	-	SYM
fnp-3806	4331	4	37	37	NUM
fnp-3806	4331	5	.	.	PUNCT
fnp-3806	4332	1	https://doi.org/10.1212/wnl.0000000000004059	https://doi.org/10.1212/wnl.0000000000004059	PROPN
fnp-3806	4332	2	jockwitz	jockwitz	PROPN
fnp-3806	4332	3	c	c	PROPN
fnp-3806	4332	4	,	,	PUNCT
fnp-3806	4332	5	caspers	caspers	PROPN
fnp-3806	4332	6	s.	s.	PROPN
fnp-3806	4332	7	resting	rest	VERB
fnp-3806	4332	8	-	-	PUNCT
fnp-3806	4332	9	state	state	NOUN
fnp-3806	4332	10	networks	network	NOUN
fnp-3806	4332	11	in	in	ADP
fnp-3806	4332	12	the	the	DET
fnp-3806	4332	13	course	course	NOUN
fnp-3806	4332	14	of	of	ADP
fnp-3806	4332	15	aging	age	VERB
fnp-3806	4332	16	-	-	PUNCT
fnp-3806	4332	17	differential	differential	NOUN
fnp-3806	4332	18	insights	insight	NOUN
fnp-3806	4332	19	from	from	ADP
fnp-3806	4332	20	studies	study	NOUN
fnp-3806	4332	21	across	across	ADP
fnp-3806	4332	22	the	the	DET
fnp-3806	4332	23	lifespan	lifespan	NOUN
fnp-3806	4332	24	vs.	vs.	ADP
fnp-3806	4332	25	amongst	amongst	ADP
fnp-3806	4332	26	the	the	DET
fnp-3806	4332	27	old	old	ADJ
fnp-3806	4332	28	.	.	PUNCT
fnp-3806	4333	1	pflugers	pfluger	NOUN
fnp-3806	4333	2	arch	arch	VERB
fnp-3806	4333	3	2021;473:793	2021;473:793	NUM
fnp-3806	4333	4	-	-	SYM
fnp-3806	4333	5	803	803	NUM
fnp-3806	4333	6	.	.	PUNCT
fnp-3806	4334	1	https://doi.org/10.1007/s00424-021-02520-7	https://doi.org/10.1007/s00424-021-02520-7	PROPN
fnp-3806	4334	2	zhang	zhang	PROPN
fnp-3806	4334	3	h	h	PROPN
fnp-3806	4334	4	,	,	PUNCT
fnp-3806	4334	5	gertel	gertel	PROPN
fnp-3806	4334	6	vh	vh	PROPN
fnp-3806	4334	7	,	,	PUNCT
fnp-3806	4334	8	cosgrove	cosgrove	PROPN
fnp-3806	4334	9	al	al	PROPN
fnp-3806	4334	10	,	,	PUNCT
fnp-3806	4334	11	et	et	PROPN
fnp-3806	4334	12	al	al	PROPN
fnp-3806	4334	13	.	.	PUNCT
fnp-3806	4334	14	age	age	NOUN
fnp-3806	4334	15	-	-	PUNCT
fnp-3806	4334	16	related	relate	VERB
fnp-3806	4334	17	differences	difference	NOUN
fnp-3806	4334	18	in	in	ADP
fnp-3806	4334	19	resting	rest	VERB
fnp-3806	4334	20	-	-	PUNCT
fnp-3806	4334	21	state	state	NOUN
fnp-3806	4334	22	and	and	CCONJ
fnp-3806	4334	23	task	task	NOUN
fnp-3806	4334	24	-	-	PUNCT
fnp-3806	4334	25	based	base	VERB
fnp-3806	4334	26	network	network	NOUN
fnp-3806	4334	27	characteristics	characteristic	NOUN
fnp-3806	4334	28	and	and	CCONJ
fnp-3806	4334	29	cognition	cognition	NOUN
fnp-3806	4334	30	:	:	PUNCT
fnp-3806	4334	31	a	a	DET
fnp-3806	4334	32	lifespan	lifespan	ADJ
fnp-3806	4334	33	sample	sample	NOUN
fnp-3806	4334	34	.	.	PUNCT
fnp-3806	4335	1	neurobiol	neurobiol	PROPN
fnp-3806	4335	2	aging	age	VERB
fnp-3806	4335	3	2021;101:262	2021;101:262	NUM
fnp-3806	4335	4	-	-	SYM
fnp-3806	4335	5	272	272	NUM
fnp-3806	4335	6	.	.	PUNCT
fnp-3806	4336	1	https://doi.org/10.1016/j.neurobiolaging.2020.10.025	https://doi.org/10.1016/j.neurobiolaging.2020.10.025	PROPN
fnp-3806	4336	2	hoenig	hoenig	PROPN
fnp-3806	4336	3	mc	mc	PROPN
fnp-3806	4336	4	,	,	PUNCT
fnp-3806	4336	5	bischof	bischof	PROPN
fnp-3806	4336	6	gn	gn	PROPN
fnp-3806	4336	7	,	,	PUNCT
fnp-3806	4336	8	seemiller	seemiller	PROPN
fnp-3806	4336	9	j	j	PROPN
fnp-3806	4336	10	,	,	PUNCT
fnp-3806	4336	11	et	et	PROPN
fnp-3806	4336	12	al	al	PROPN
fnp-3806	4336	13	.	.	PUNCT
fnp-3806	4336	14	networks	network	NOUN
fnp-3806	4336	15	of	of	ADP
fnp-3806	4336	16	tau	tau	PROPN
fnp-3806	4336	17	distribution	distribution	NOUN
fnp-3806	4336	18	in	in	ADP
fnp-3806	4336	19	alzheimer	alzheimer	PROPN
fnp-3806	4336	20	's	's	PART
fnp-3806	4336	21	disease	disease	NOUN
fnp-3806	4336	22	.	.	PUNCT
fnp-3806	4337	1	brain	brain	NOUN
fnp-3806	4337	2	2018;141:568	2018;141:568	NUM
fnp-3806	4337	3	-	-	SYM
fnp-3806	4337	4	581	581	NUM
fnp-3806	4337	5	.	.	PUNCT
fnp-3806	4338	1	https://doi.org/10.1093/brain/awx353	https://doi.org/10.1093/brain/awx353	NOUN
fnp-3806	4338	2	zheng	zheng	PROPN
fnp-3806	4338	3	w	w	PROPN
fnp-3806	4338	4	,	,	PUNCT
fnp-3806	4338	5	yao	yao	PROPN
fnp-3806	4338	6	z	z	PROPN
fnp-3806	4338	7	,	,	PUNCT
fnp-3806	4338	8	xie	xie	PROPN
fnp-3806	4338	9	y	y	PROPN
fnp-3806	4338	10	,	,	PUNCT
fnp-3806	4338	11	et	et	PROPN
fnp-3806	4338	12	al	al	PROPN
fnp-3806	4338	13	.	.	PUNCT
fnp-3806	4338	14	identification	identification	NOUN
fnp-3806	4338	15	of	of	ADP
fnp-3806	4338	16	alzheimer	alzheimer	PROPN
fnp-3806	4338	17	's	's	PART
fnp-3806	4338	18	disease	disease	NOUN
fnp-3806	4338	19	and	and	CCONJ
fnp-3806	4338	20	mild	mild	ADJ
fnp-3806	4338	21	cognitive	cognitive	ADJ
fnp-3806	4338	22	impairment	impairment	NOUN
fnp-3806	4338	23	using	use	VERB
fnp-3806	4338	24	networks	network	NOUN
fnp-3806	4338	25	constructed	construct	VERB
fnp-3806	4338	26	based	base	VERB
fnp-3806	4338	27	on	on	ADP
fnp-3806	4338	28	multiple	multiple	ADJ
fnp-3806	4338	29	morphological	morphological	ADJ
fnp-3806	4338	30	brain	brain	NOUN
fnp-3806	4338	31	features	feature	NOUN
fnp-3806	4338	32	.	.	PUNCT
fnp-3806	4339	1	biol	biol	PROPN
fnp-3806	4339	2	psychiatry	psychiatry	PROPN
fnp-3806	4339	3	cogn	cogn	VERB
fnp-3806	4339	4	neurosci	neurosci	PROPN
fnp-3806	4339	5	neuroimaging	neuroimaging	NOUN
fnp-3806	4339	6	.	.	PUNCT
fnp-3806	4340	1	2018;3:887	2018;3:887	NUM
fnp-3806	4340	2	-	-	SYM
fnp-3806	4340	3	897	897	NUM
fnp-3806	4340	4	.	.	PUNCT
fnp-3806	4341	1	https://doi.org/10.1016/j.bpsc.2018.06.004	https://doi.org/10.1016/j.bpsc.2018.06.004	PROPN
fnp-3806	4341	2	pelkmans	pelkmans	PROPN
fnp-3806	4341	3	w	w	PROPN
fnp-3806	4341	4	,	,	PUNCT
fnp-3806	4341	5	ossenkoppele	ossenkoppele	PROPN
fnp-3806	4341	6	r	r	PROPN
fnp-3806	4341	7	,	,	PUNCT
fnp-3806	4341	8	dicks	dick	NOUN
fnp-3806	4341	9	e	e	NOUN
fnp-3806	4341	10	,	,	PUNCT
fnp-3806	4341	11	et	et	PROPN
fnp-3806	4341	12	al	al	PROPN
fnp-3806	4341	13	.	.	PUNCT
fnp-3806	4342	1	tau	tau	PROPN
fnp-3806	4342	2	-	-	PUNCT
fnp-3806	4342	3	related	relate	VERB
fnp-3806	4342	4	grey	grey	NOUN
fnp-3806	4342	5	matter	matter	NOUN
fnp-3806	4342	6	network	network	NOUN
fnp-3806	4342	7	breakdown	breakdown	NOUN
fnp-3806	4342	8	across	across	ADP
fnp-3806	4342	9	the	the	DET
fnp-3806	4342	10	alzheimer	alzheimer	PROPN
fnp-3806	4342	11	's	's	PART
fnp-3806	4342	12	disease	disease	NOUN
fnp-3806	4342	13	continuum	continuum	PROPN
fnp-3806	4342	14	.	.	PUNCT
fnp-3806	4343	1	alzheimers	alzheimer	NOUN
fnp-3806	4343	2	res	re	NOUN
fnp-3806	4343	3	ther	ther	ADV
fnp-3806	4343	4	2021;13:138	2021;13:138	PROPN
fnp-3806	4343	5	.	.	PUNCT
fnp-3806	4344	1	https://doi.org/10.1186/s13195-021-00876-7	https://doi.org/10.1186/s13195-021-00876-7	PROPN
fnp-3806	4344	2	shigemoto	shigemoto	PROPN
fnp-3806	4344	3	y	y	PROPN
fnp-3806	4344	4	,	,	PUNCT
fnp-3806	4344	5	sone	sone	NOUN
fnp-3806	4345	1	d	d	NOUN
fnp-3806	4345	2	,	,	PUNCT
fnp-3806	4345	3	okita	okita	PROPN
fnp-3806	4345	4	k	k	PROPN
fnp-3806	4345	5	,	,	PUNCT
fnp-3806	4345	6	et	et	PROPN
fnp-3806	4345	7	al	al	PROPN
fnp-3806	4345	8	.	.	PROPN
fnp-3806	4345	9	gray	gray	PROPN
fnp-3806	4345	10	matter	matter	NOUN
fnp-3806	4345	11	structural	structural	ADJ
fnp-3806	4345	12	networks	network	NOUN
fnp-3806	4345	13	related	relate	VERB
fnp-3806	4345	14	to	to	ADP
fnp-3806	4345	15	(	(	PUNCT
fnp-3806	4345	16	18)f	18)f	NUM
fnp-3806	4345	17	-	-	PUNCT
fnp-3806	4345	18	thk5351	thk5351	NOUN
fnp-3806	4345	19	retention	retention	NOUN
fnp-3806	4345	20	in	in	ADP
fnp-3806	4345	21	cognitively	cognitively	ADV
fnp-3806	4345	22	normal	normal	ADJ
fnp-3806	4345	23	older	old	ADJ
fnp-3806	4345	24	adults	adult	NOUN
fnp-3806	4345	25	and	and	CCONJ
fnp-3806	4345	26	alzheimer	alzheimer	PROPN
fnp-3806	4345	27	's	's	PART
fnp-3806	4345	28	disease	disease	NOUN
fnp-3806	4345	29	patients	patient	NOUN
fnp-3806	4345	30	.	.	PUNCT
fnp-3806	4346	1	neurological	neurological	ADJ
fnp-3806	4346	2	sci	sci	PROPN
fnp-3806	4346	3	2021;22:100309	2021;22:100309	NUM
fnp-3806	4346	4	.	.	PUNCT
fnp-3806	4347	1	https://doi.org/10.1016/j.ensci.2021.100309	https://doi.org/10.1016/j.ensci.2021.100309	PROPN
fnp-3806	4347	2	smith	smith	PROPN
fnp-3806	4347	3	rx	rx	PROPN
fnp-3806	4347	4	,	,	PUNCT
fnp-3806	4347	5	strain	strain	PROPN
fnp-3806	4347	6	jf	jf	PROPN
fnp-3806	4347	7	,	,	PUNCT
fnp-3806	4347	8	tanenbaum	tanenbaum	PROPN
fnp-3806	4347	9	a	a	PROPN
fnp-3806	4347	10	,	,	PUNCT
fnp-3806	4347	11	et	et	PROPN
fnp-3806	4347	12	al	al	PROPN
fnp-3806	4347	13	.	.	PUNCT
fnp-3806	4347	14	resting	rest	VERB
fnp-3806	4347	15	-	-	PUNCT
fnp-3806	4347	16	state	state	NOUN
fnp-3806	4347	17	functional	functional	ADJ
fnp-3806	4347	18	connectivity	connectivity	NOUN
fnp-3806	4347	19	disruption	disruption	NOUN
fnp-3806	4347	20	as	as	ADP
fnp-3806	4347	21	a	a	DET
fnp-3806	4347	22	pathological	pathological	ADJ
fnp-3806	4347	23	biomarker	biomarker	NOUN
fnp-3806	4347	24	in	in	ADP
fnp-3806	4347	25	autosomal	autosomal	ADJ
fnp-3806	4347	26	dominant	dominant	ADJ
fnp-3806	4347	27	alzheimer	alzheimer	PROPN
fnp-3806	4347	28	disease	disease	NOUN
fnp-3806	4347	29	.	.	PUNCT
fnp-3806	4348	1	brain	brain	NOUN
fnp-3806	4348	2	connect	connect	PROPN
fnp-3806	4348	3	2021;11:239	2021;11:239	NUM
fnp-3806	4348	4	-	-	SYM
fnp-3806	4348	5	249	249	NUM
fnp-3806	4348	6	.	.	PUNCT
fnp-3806	4349	1	https://doi.org/10.1089/brain.2020.0808	https://doi.org/10.1089/brain.2020.0808	PROPN
fnp-3806	4349	2	wu	wu	PROPN
fnp-3806	4349	3	z	z	PROPN
fnp-3806	4349	4	,	,	PUNCT
fnp-3806	4349	5	gao	gao	PROPN
fnp-3806	4349	6	y	y	PROPN
fnp-3806	4349	7	,	,	PUNCT
fnp-3806	4349	8	potter	potter	PROPN
fnp-3806	4349	9	t	t	PROPN
fnp-3806	4349	10	,	,	PUNCT
fnp-3806	4349	11	et	et	PROPN
fnp-3806	4349	12	al	al	PROPN
fnp-3806	4349	13	.	.	PUNCT
fnp-3806	4350	1	interactions	interaction	NOUN
fnp-3806	4350	2	between	between	ADP
fnp-3806	4350	3	aging	age	VERB
fnp-3806	4350	4	and	and	CCONJ
fnp-3806	4350	5	alzheimer	alzheimer	NOUN
fnp-3806	4350	6	’s	’s	PART
fnp-3806	4350	7	disease	disease	NOUN
fnp-3806	4350	8	on	on	ADP
fnp-3806	4350	9	structural	structural	ADJ
fnp-3806	4350	10	brain	brain	NOUN
fnp-3806	4350	11	networks	network	NOUN
fnp-3806	4350	12	.	.	PUNCT
fnp-3806	4351	1	aging	age	VERB
fnp-3806	4351	2	neurosci	neurosci	NOUN
fnp-3806	4351	3	2021;13:639795	2021;13:639795	NUM
fnp-3806	4351	4	.	.	PUNCT
fnp-3806	4352	1	https://doi.org/10.3389/fnagi.2021.639795	https://doi.org/10.3389/fnagi.2021.639795	PROPN
fnp-3806	4352	2	hasani	hasani	PROPN
fnp-3806	4352	3	sa	sa	PROPN
fnp-3806	4352	4	,	,	PUNCT
fnp-3806	4352	5	mayeli	mayeli	PROPN
fnp-3806	4352	6	m	m	PROPN
fnp-3806	4352	7	,	,	PUNCT
fnp-3806	4352	8	salehi	salehi	PROPN
fnp-3806	4352	9	ma	ma	PROPN
fnp-3806	4352	10	,	,	PUNCT
fnp-3806	4352	11	et	et	PROPN
fnp-3806	4352	12	al	al	PROPN
fnp-3806	4352	13	.	.	PUNCT
fnp-3806	4353	1	a	a	DET
fnp-3806	4353	2	systematic	systematic	ADJ
fnp-3806	4353	3	review	review	NOUN
fnp-3806	4353	4	of	of	ADP
fnp-3806	4353	5	the	the	DET
fnp-3806	4353	6	association	association	NOUN
fnp-3806	4353	7	between	between	ADP
fnp-3806	4353	8	amyloid	amyloid	NOUN
fnp-3806	4353	9	-	-	PUNCT
fnp-3806	4353	10	beta	beta	NOUN
fnp-3806	4353	11	and	and	CCONJ
fnp-3806	4353	12	tau	tau	PROPN
fnp-3806	4353	13	pathology	pathology	NOUN
fnp-3806	4353	14	with	with	ADP
fnp-3806	4353	15	functional	functional	ADJ
fnp-3806	4353	16	connectivity	connectivity	NOUN
fnp-3806	4353	17	alterations	alteration	NOUN
fnp-3806	4353	18	in	in	ADP
fnp-3806	4353	19	the	the	DET
fnp-3806	4353	20	alzheimer	alzheimer	PROPN
fnp-3806	4353	21	dementia	dementia	PROPN
fnp-3806	4353	22	spectrum	spectrum	NOUN
fnp-3806	4353	23	utilizing	utilize	VERB
fnp-3806	4353	24	pet	pet	ADJ
fnp-3806	4353	25	scan	scan	NOUN
fnp-3806	4353	26	and	and	CCONJ
fnp-3806	4353	27	rsfmri	rsfmri	ADJ
fnp-3806	4353	28	.	.	PUNCT
fnp-3806	4354	1	dement	dement	PROPN
fnp-3806	4354	2	geriatr	geriatr	PROPN
fnp-3806	4354	3	cogn	cogn	VERB
fnp-3806	4354	4	dis	dis	PROPN
fnp-3806	4354	5	extra	extra	ADJ
fnp-3806	4354	6	2021;11:78	2021;11:78	NUM
fnp-3806	4354	7	-	-	SYM
fnp-3806	4354	8	90	90	NUM
fnp-3806	4354	9	.	.	PUNCT
fnp-3806	4355	1	https://doi.org/10.1159/000516164	https://doi.org/10.1159/000516164	NOUN
fnp-3806	4355	2	ewers	ewer	NOUN
fnp-3806	4355	3	m	m	PROPN
fnp-3806	4355	4	,	,	PUNCT
fnp-3806	4355	5	luan	luan	PROPN
fnp-3806	4355	6	y	y	PROPN
fnp-3806	4355	7	,	,	PUNCT
fnp-3806	4355	8	frontzkowski	frontzkowski	ADJ
fnp-3806	4355	9	l	l	NOUN
fnp-3806	4355	10	,	,	PUNCT
fnp-3806	4355	11	et	et	PROPN
fnp-3806	4355	12	al	al	PROPN
fnp-3806	4355	13	.	.	PROPN
fnp-3806	4355	14	segregation	segregation	NOUN
fnp-3806	4355	15	of	of	ADP
fnp-3806	4355	16	functional	functional	ADJ
fnp-3806	4355	17	networks	network	NOUN
fnp-3806	4355	18	is	be	AUX
fnp-3806	4355	19	associated	associate	VERB
fnp-3806	4355	20	with	with	ADP
fnp-3806	4355	21	cognitive	cognitive	ADJ
fnp-3806	4355	22	resilience	resilience	NOUN
fnp-3806	4355	23	in	in	ADP
fnp-3806	4355	24	alzheimer	alzheimer	PROPN
fnp-3806	4355	25	's	's	PART
fnp-3806	4355	26	disease	disease	NOUN
fnp-3806	4355	27	.	.	PUNCT
fnp-3806	4356	1	brain	brain	NOUN
fnp-3806	4356	2	2021;144:2176	2021;144:2176	NOUN
fnp-3806	4356	3	-	-	PUNCT
fnp-3806	4356	4	2185	2185	NUM
fnp-3806	4356	5	.	.	PUNCT
fnp-3806	4357	1	https://doi.org/10.1093/brain/awab112	https://doi.org/10.1093/brain/awab112	ADJ
fnp-3806	4357	2	king	king	PROPN
fnp-3806	4357	3	-	-	PUNCT
fnp-3806	4357	4	robson	robson	PROPN
fnp-3806	4357	5	j	j	PROPN
fnp-3806	4357	6	,	,	PUNCT
fnp-3806	4357	7	wilson	wilson	PROPN
fnp-3806	4357	8	h	h	PROPN
fnp-3806	4357	9	,	,	PUNCT
fnp-3806	4357	10	politis	politis	PROPN
fnp-3806	4357	11	m	m	PROPN
fnp-3806	4357	12	,	,	PUNCT
fnp-3806	4357	13	et	et	PROPN
fnp-3806	4357	14	al	al	PROPN
fnp-3806	4357	15	.	.	PROPN
fnp-3806	4357	16	associations	association	NOUN
fnp-3806	4357	17	between	between	ADP
fnp-3806	4357	18	amyloid	amyloid	NOUN
fnp-3806	4357	19	and	and	CCONJ
fnp-3806	4357	20	tau	tau	PROPN
fnp-3806	4357	21	pathology	pathology	NOUN
fnp-3806	4357	22	,	,	PUNCT
fnp-3806	4357	23	and	and	CCONJ
fnp-3806	4357	24	connectome	connectome	PROPN
fnp-3806	4357	25	alterations	alteration	NOUN
fnp-3806	4357	26	,	,	PUNCT
fnp-3806	4357	27	in	in	ADP
fnp-3806	4357	28	alzheimer	alzheimer	PROPN
fnp-3806	4357	29	's	's	PART
fnp-3806	4357	30	disease	disease	NOUN
fnp-3806	4357	31	and	and	CCONJ
fnp-3806	4357	32	mild	mild	ADJ
fnp-3806	4357	33	cognitive	cognitive	ADJ
fnp-3806	4357	34	impairment	impairment	NOUN
fnp-3806	4357	35	.	.	PUNCT
fnp-3806	4358	1	j	j	PROPN
fnp-3806	4358	2	alzheimers	alzheimers	PROPN
fnp-3806	4358	3	dis	dis	PROPN
fnp-3806	4358	4	2021;82:541	2021;82:541	NUM
fnp-3806	4358	5	-	-	SYM
fnp-3806	4358	6	560	560	NUM
fnp-3806	4358	7	.	.	PUNCT
fnp-3806	4359	1	https://doi.org/10.3233/jad-201457	https://doi.org/10.3233/jad-201457	PROPN
fnp-3806	4359	2	cassady	cassady	PROPN
fnp-3806	4359	3	ke	ke	PROPN
fnp-3806	4359	4	,	,	PUNCT
fnp-3806	4359	5	adams	adams	PROPN
fnp-3806	4359	6	jn	jn	PROPN
fnp-3806	4359	7	,	,	PUNCT
fnp-3806	4359	8	chen	chen	PROPN
fnp-3806	4359	9	x	x	PROPN
fnp-3806	4359	10	,	,	PUNCT
fnp-3806	4359	11	et	et	PROPN
fnp-3806	4359	12	al	al	PROPN
fnp-3806	4359	13	.	.	PROPN
fnp-3806	4359	14	alzheimer	alzheimer	PROPN
fnp-3806	4359	15	's	's	PART
fnp-3806	4359	16	pathology	pathology	NOUN
fnp-3806	4359	17	is	be	AUX
fnp-3806	4359	18	associated	associate	VERB
fnp-3806	4359	19	with	with	ADP
fnp-3806	4359	20	dedifferentiation	dedifferentiation	NOUN
fnp-3806	4359	21	of	of	ADP
fnp-3806	4359	22	intrinsic	intrinsic	ADJ
fnp-3806	4359	23	functional	functional	ADJ
fnp-3806	4359	24	memory	memory	NOUN
fnp-3806	4359	25	networks	network	NOUN
fnp-3806	4359	26	in	in	ADP
fnp-3806	4359	27	aging	age	VERB
fnp-3806	4359	28	.	.	PUNCT
fnp-3806	4360	1	cereb	cereb	VERB
fnp-3806	4360	2	cortex	cortex	NOUN
fnp-3806	4360	3	2021;31:4781	2021;31:4781	NUM
fnp-3806	4360	4	-	-	SYM
fnp-3806	4360	5	4793	4793	NUM
fnp-3806	4360	6	.	.	PUNCT
fnp-3806	4361	1	https://doi.org/10.1093/cercor/bhab122	https://doi.org/10.1093/cercor/bhab122	X
fnp-3806	4361	2	vos	vos	PROPN
fnp-3806	4361	3	sj	sj	PROPN
fnp-3806	4361	4	,	,	PUNCT
fnp-3806	4361	5	xiong	xiong	PROPN
fnp-3806	4361	6	c	c	PROPN
fnp-3806	4361	7	,	,	PUNCT
fnp-3806	4361	8	visser	visser	PROPN
fnp-3806	4361	9	pj	pj	PROPN
fnp-3806	4361	10	,	,	PUNCT
fnp-3806	4361	11	et	et	PROPN
fnp-3806	4361	12	al	al	PROPN
fnp-3806	4361	13	.	.	PROPN
fnp-3806	4362	1	preclinical	preclinical	PROPN
fnp-3806	4362	2	alzheimer	alzheimer	PROPN
fnp-3806	4362	3	's	's	PART
fnp-3806	4362	4	disease	disease	NOUN
fnp-3806	4362	5	and	and	CCONJ
fnp-3806	4362	6	its	its	PRON
fnp-3806	4362	7	outcome	outcome	NOUN
fnp-3806	4362	8	:	:	PUNCT
fnp-3806	4362	9	a	a	DET
fnp-3806	4362	10	longitudinal	longitudinal	ADJ
fnp-3806	4362	11	cohort	cohort	NOUN
fnp-3806	4362	12	study	study	NOUN
fnp-3806	4362	13	.	.	PUNCT
fnp-3806	4363	1	lancet	lancet	PROPN
fnp-3806	4363	2	neurol	neurol	PROPN
fnp-3806	4363	3	2013;12:957	2013;12:957	NOUN
fnp-3806	4363	4	-	-	SYM
fnp-3806	4363	5	965	965	NUM
fnp-3806	4363	6	.	.	PUNCT
fnp-3806	4364	1	https://doi.org/10.1016/s1474-4422(13)70194-7	https://doi.org/10.1016/s1474-4422(13)70194-7	PROPN
fnp-3806	4364	2	dubois	dubois	PROPN
fnp-3806	4364	3	b	b	PROPN
fnp-3806	4364	4	,	,	PUNCT
fnp-3806	4364	5	feldman	feldman	PROPN
fnp-3806	4364	6	hh	hh	PROPN
fnp-3806	4364	7	,	,	PUNCT
fnp-3806	4364	8	jacova	jacova	VERB
fnp-3806	4364	9	c	c	X
fnp-3806	4364	10	,	,	PUNCT
fnp-3806	4364	11	et	et	PROPN
fnp-3806	4364	12	al	al	PROPN
fnp-3806	4364	13	.	.	PUNCT
fnp-3806	4364	14	advancing	advance	VERB
fnp-3806	4364	15	research	research	NOUN
fnp-3806	4364	16	diagnostic	diagnostic	ADJ
fnp-3806	4364	17	criteria	criterion	NOUN
fnp-3806	4364	18	for	for	ADP
fnp-3806	4364	19	alzheimer	alzheimer	PROPN
fnp-3806	4364	20	’s	’s	PART
fnp-3806	4364	21	disease	disease	NOUN
fnp-3806	4364	22	:	:	PUNCT
fnp-3806	4364	23	the	the	DET
fnp-3806	4364	24	iwg-2	iwg-2	ADJ
fnp-3806	4364	25	criteria	criterion	NOUN
fnp-3806	4364	26	.	.	PUNCT
fnp-3806	4365	1	lancet	lancet	PROPN
fnp-3806	4365	2	neurol	neurol	PROPN
fnp-3806	4365	3	2014;13:614	2014;13:614	NUM
fnp-3806	4365	4	-	-	SYM
fnp-3806	4365	5	629	629	NUM
fnp-3806	4365	6	.	.	PUNCT
fnp-3806	4366	1	https://doi.org/10.1016/s1474-4422(14)70090-0	https://doi.org/10.1016/s1474-4422(14)70090-0	PROPN
fnp-3806	4366	2	olsson	olsson	PROPN
fnp-3806	4366	3	b	b	PROPN
fnp-3806	4366	4	,	,	PUNCT
fnp-3806	4366	5	lautner	lautner	ADJ
fnp-3806	4366	6	r	r	NOUN
fnp-3806	4366	7	,	,	PUNCT
fnp-3806	4366	8	andreasson	andreasson	NOUN
fnp-3806	4366	9	u	u	NOUN
fnp-3806	4366	10	,	,	PUNCT
fnp-3806	4366	11	et	et	PROPN
fnp-3806	4366	12	al	al	PROPN
fnp-3806	4366	13	.	.	PROPN
fnp-3806	4366	14	csf	csf	PROPN
fnp-3806	4366	15	and	and	CCONJ
fnp-3806	4366	16	blood	blood	NOUN
fnp-3806	4366	17	biomarkers	biomarker	NOUN
fnp-3806	4366	18	for	for	ADP
fnp-3806	4366	19	the	the	DET
fnp-3806	4366	20	diagnosis	diagnosis	NOUN
fnp-3806	4366	21	of	of	ADP
fnp-3806	4366	22	alzheimer	alzheimer	PROPN
fnp-3806	4366	23	's	's	PART
fnp-3806	4366	24	disease	disease	NOUN
fnp-3806	4366	25	:	:	PUNCT
fnp-3806	4366	26	a	a	DET
fnp-3806	4366	27	systematic	systematic	ADJ
fnp-3806	4366	28	review	review	NOUN
fnp-3806	4366	29	and	and	CCONJ
fnp-3806	4366	30	meta	meta	ADJ
fnp-3806	4366	31	-	-	PUNCT
fnp-3806	4366	32	analysis	analysis	NOUN
fnp-3806	4366	33	.	.	PUNCT
fnp-3806	4367	1	lancet	lancet	PROPN
fnp-3806	4367	2	neurol	neurol	PROPN
fnp-3806	4367	3	2016;15:673	2016;15:673	PROPN
fnp-3806	4367	4	-	-	PUNCT
fnp-3806	4367	5	684	684	NUM
fnp-3806	4367	6	.	.	PUNCT
fnp-3806	4368	1	https://doi.org/10.1016/s1474-4422(16)00070-3	https://doi.org/10.1016/s1474-4422(16)00070-3	PROPN
fnp-3806	4368	2	sperling	sperling	PROPN
fnp-3806	4368	3	ra	ra	PROPN
fnp-3806	4368	4	,	,	PUNCT
fnp-3806	4368	5	donohue	donohue	PROPN
fnp-3806	4368	6	mc	mc	PROPN
fnp-3806	4368	7	,	,	PUNCT
fnp-3806	4368	8	raman	raman	NOUN
fnp-3806	4368	9	r	r	NOUN
fnp-3806	4368	10	,	,	PUNCT
fnp-3806	4368	11	et	et	PROPN
fnp-3806	4368	12	al	al	PROPN
fnp-3806	4368	13	.	.	PROPN
fnp-3806	4368	14	association	association	NOUN
fnp-3806	4368	15	of	of	ADP
fnp-3806	4368	16	factors	factor	NOUN
fnp-3806	4368	17	with	with	ADP
fnp-3806	4368	18	elevated	elevated	ADJ
fnp-3806	4368	19	amyloid	amyloid	NOUN
fnp-3806	4368	20	burden	burden	NOUN
fnp-3806	4368	21	in	in	ADP
fnp-3806	4368	22	clinically	clinically	ADV
fnp-3806	4368	23	normal	normal	ADJ
fnp-3806	4368	24	older	old	ADJ
fnp-3806	4368	25	individuals	individual	NOUN
fnp-3806	4368	26	.	.	PUNCT
fnp-3806	4369	1	jama	jama	PROPN
fnp-3806	4369	2	neurol	neurol	PROPN
fnp-3806	4369	3	2020;77:735	2020;77:735	PROPN
fnp-3806	4369	4	-	-	SYM
fnp-3806	4369	5	745	745	NUM
fnp-3806	4369	6	.	.	PUNCT
fnp-3806	4370	1	https://doi.org/10.1001/jamaneurol.2020.0387	https://doi.org/10.1001/jamaneurol.2020.0387	PROPN
fnp-3806	4370	2	zhang	zhang	PROPN
fnp-3806	4370	3	k	k	PROPN
fnp-3806	4370	4	,	,	PUNCT
fnp-3806	4370	5	mizuma	mizuma	PROPN
fnp-3806	4370	6	h	h	PROPN
fnp-3806	4370	7	,	,	PUNCT
fnp-3806	4370	8	zhang	zhang	PROPN
fnp-3806	4370	9	x	x	PROPN
fnp-3806	4370	10	,	,	PUNCT
fnp-3806	4370	11	et	et	PROPN
fnp-3806	4370	12	al	al	PROPN
fnp-3806	4370	13	.	.	PROPN
fnp-3806	4370	14	pet	pet	PROPN
fnp-3806	4370	15	imaging	imaging	NOUN
fnp-3806	4370	16	of	of	ADP
fnp-3806	4370	17	neural	neural	ADJ
fnp-3806	4370	18	activity	activity	NOUN
fnp-3806	4370	19	,	,	PUNCT
fnp-3806	4370	20	beta	beta	NOUN
fnp-3806	4370	21	-	-	PUNCT
fnp-3806	4370	22	amyloid	amyloid	NOUN
fnp-3806	4370	23	,	,	PUNCT
fnp-3806	4370	24	and	and	CCONJ
fnp-3806	4370	25	tau	tau	PROPN
fnp-3806	4370	26	in	in	ADP
fnp-3806	4370	27	normal	normal	ADJ
fnp-3806	4370	28	brain	brain	NOUN
fnp-3806	4370	29	aging	aging	NOUN
fnp-3806	4370	30	.	.	PUNCT
fnp-3806	4371	1	eur	eur	PROPN
fnp-3806	4371	2	j	j	PROPN
fnp-3806	4371	3	nucl	nucl	PROPN
fnp-3806	4371	4	med	me	VERB
fnp-3806	4371	5	mol	mol	ADP
fnp-3806	4371	6	imaging	image	VERB
fnp-3806	4371	7	2021;48:3859	2021;48:3859	PROPN
fnp-3806	4371	8	-	-	PUNCT
fnp-3806	4371	9	3871	3871	NUM
fnp-3806	4371	10	.	.	PUNCT
fnp-3806	4372	1	https://doi.org/10.1007/s00259-021-05230-5	https://doi.org/10.1007/s00259-021-05230-5	PROPN
fnp-3806	4373	1	dubois	dubois	PROPN
fnp-3806	4373	2	b	b	PROPN
fnp-3806	4373	3	,	,	PUNCT
fnp-3806	4373	4	hampel	hampel	PROPN
fnp-3806	4373	5	h	h	PROPN
fnp-3806	4373	6	,	,	PUNCT
fnp-3806	4373	7	feldman	feldman	PROPN
fnp-3806	4373	8	hh	hh	PROPN
fnp-3806	4373	9	,	,	PUNCT
fnp-3806	4373	10	et	et	PROPN
fnp-3806	4373	11	al	al	PROPN
fnp-3806	4373	12	.	.	PROPN
fnp-3806	4374	1	preclinical	preclinical	PROPN
fnp-3806	4374	2	alzheimer	alzheimer	PROPN
fnp-3806	4374	3	's	's	PART
fnp-3806	4374	4	disease	disease	NOUN
fnp-3806	4374	5	:	:	PUNCT
fnp-3806	4374	6	definition	definition	NOUN
fnp-3806	4374	7	,	,	PUNCT
fnp-3806	4374	8	natural	natural	ADJ
fnp-3806	4374	9	history	history	NOUN
fnp-3806	4374	10	,	,	PUNCT
fnp-3806	4374	11	and	and	CCONJ
fnp-3806	4374	12	diagnostic	diagnostic	ADJ
fnp-3806	4374	13	criteria	criterion	NOUN
fnp-3806	4374	14	.	.	PUNCT
fnp-3806	4375	1	alzheimers	alzheimer	NOUN
fnp-3806	4375	2	dement	dement	PROPN
fnp-3806	4375	3	2016;12	2016;12	NUM
fnp-3806	4375	4	:	:	PUNCT
fnp-3806	4375	5	292	292	NUM
fnp-3806	4375	6	-	-	SYM
fnp-3806	4375	7	323	323	NUM
fnp-3806	4375	8	.	.	PUNCT
fnp-3806	4376	1	https://doi.org/10.1016/j.jalz.2016.02.002	https://doi.org/10.1016/j.jalz.2016.02.002	NOUN
fnp-3806	4376	2	rossini	rossini	ADJ
fnp-3806	4376	3	pm	pm	NOUN
fnp-3806	4376	4	,	,	PUNCT
fnp-3806	4376	5	di	di	X
fnp-3806	4376	6	iorio	iorio	PROPN
fnp-3806	4376	7	r	r	PROPN
fnp-3806	4376	8	,	,	PUNCT
fnp-3806	4376	9	vecchio	vecchio	PROPN
fnp-3806	4376	10	f	f	PROPN
fnp-3806	4376	11	,	,	PUNCT
fnp-3806	4376	12	et	et	PROPN
fnp-3806	4376	13	al	al	PROPN
fnp-3806	4376	14	.	.	PROPN
fnp-3806	4377	1	early	early	ADJ
fnp-3806	4377	2	diagnosis	diagnosis	NOUN
fnp-3806	4377	3	of	of	ADP
fnp-3806	4377	4	alzheimer	alzheimer	PROPN
fnp-3806	4377	5	's	's	PART
fnp-3806	4377	6	disease	disease	NOUN
fnp-3806	4377	7	:	:	PUNCT
fnp-3806	4377	8	the	the	DET
fnp-3806	4377	9	role	role	NOUN
fnp-3806	4377	10	of	of	ADP
fnp-3806	4377	11	biomarkers	biomarker	NOUN
fnp-3806	4377	12	including	include	VERB
fnp-3806	4377	13	advanced	advanced	ADJ
fnp-3806	4377	14	eeg	eeg	NOUN
fnp-3806	4377	15	signal	signal	NOUN
fnp-3806	4377	16	analysis	analysis	NOUN
fnp-3806	4377	17	.	.	PUNCT
fnp-3806	4378	1	report	report	NOUN
fnp-3806	4378	2	from	from	ADP
fnp-3806	4378	3	the	the	DET
fnp-3806	4378	4	ifcn	ifcn	NOUN
fnp-3806	4378	5	-	-	PUNCT
fnp-3806	4378	6	sponsored	sponsor	VERB
fnp-3806	4378	7	panel	panel	NOUN
fnp-3806	4378	8	of	of	ADP
fnp-3806	4378	9	experts	expert	NOUN
fnp-3806	4378	10	.	.	PUNCT
fnp-3806	4379	1	clin	clin	PROPN
fnp-3806	4379	2	neurophysiol	neurophysiol	PROPN
fnp-3806	4379	3	2020;131:1287	2020;131:1287	NUM
fnp-3806	4379	4	-	-	SYM
fnp-3806	4379	5	1310	1310	NUM
fnp-3806	4379	6	.	.	PUNCT
fnp-3806	4380	1	https://doi.org/10.1016/j.jalz.2016.02.002	https://doi.org/10.1016/j.jalz.2016.02.002	NOUN
fnp-3806	4380	2	zetterberg	zetterberg	PROPN
fnp-3806	4380	3	h	h	PROPN
fnp-3806	4380	4	,	,	PUNCT
fnp-3806	4380	5	bendlin	bendlin	PROPN
fnp-3806	4380	6	bb	bb	PROPN
fnp-3806	4380	7	.	.	PUNCT
fnp-3806	4380	8	biomarkers	biomarker	NOUN
fnp-3806	4380	9	for	for	ADP
fnp-3806	4380	10	alzheimer	alzheimer	PROPN
fnp-3806	4380	11	’s	’s	PART
fnp-3806	4380	12	disease	disease	NOUN
fnp-3806	4380	13	-	-	PUNCT
fnp-3806	4380	14	preparing	prepare	VERB
fnp-3806	4380	15	for	for	ADP
fnp-3806	4380	16	a	a	DET
fnp-3806	4380	17	new	new	ADJ
fnp-3806	4380	18	era	era	NOUN
fnp-3806	4380	19	of	of	ADP
fnp-3806	4380	20	disease	disease	NOUN
fnp-3806	4380	21	-	-	PUNCT
fnp-3806	4380	22	modifying	modify	VERB
fnp-3806	4380	23	therapies	therapy	NOUN
fnp-3806	4380	24	.	.	PUNCT
fnp-3806	4381	1	mol	mol	ADP
fnp-3806	4381	2	psychiatry	psychiatry	NOUN
fnp-3806	4381	3	2021;26:296	2021;26:296	NOUN
fnp-3806	4381	4	-	-	SYM
fnp-3806	4381	5	308	308	NUM
fnp-3806	4381	6	.	.	PUNCT
fnp-3806	4381	7	https://doi.org/10.1038/s41380-020-0721-9	https://doi.org/10.1038/s41380-020-0721-9	PROPN
fnp-3806	4381	8	teunissen	teunissen	PROPN
fnp-3806	4381	9	ce	ce	PROPN
fnp-3806	4381	10	,	,	PUNCT
fnp-3806	4381	11	verberk	verberk	NOUN
fnp-3806	4381	12	imw	imw	NOUN
fnp-3806	4381	13	,	,	PUNCT
fnp-3806	4381	14	thijssen	thijssen	VERB
fnp-3806	4381	15	eh	eh	INTJ
fnp-3806	4381	16	,	,	PUNCT
fnp-3806	4381	17	et	et	PROPN
fnp-3806	4381	18	al	al	PROPN
fnp-3806	4381	19	.	.	PUNCT
fnp-3806	4381	20	blood	blood	NOUN
fnp-3806	4381	21	-	-	PUNCT
fnp-3806	4381	22	bassed	basse	VERB
fnp-3806	4381	23	biomarkers	biomarker	NOUN
fnp-3806	4381	24	for	for	ADP
fnp-3806	4381	25	alzheimer	alzheimer	PROPN
fnp-3806	4381	26	’s	’s	PART
fnp-3806	4381	27	disease	disease	NOUN
fnp-3806	4381	28	:	:	PUNCT
fnp-3806	4381	29	towards	towards	ADP
fnp-3806	4381	30	clinical	clinical	ADJ
fnp-3806	4381	31	implementation	implementation	NOUN
fnp-3806	4381	32	.	.	PUNCT
fnp-3806	4382	1	lancet	lancet	PROPN
fnp-3806	4382	2	neurol	neurol	PROPN
fnp-3806	4382	3	2022;21:66	2022;21:66	NUM
fnp-3806	4382	4	-	-	SYM
fnp-3806	4382	5	77	77	NUM
fnp-3806	4382	6	.	.	PUNCT
fnp-3806	4383	1	https://doi.org/10.1016/s1474-4422(21)00361-6	https://doi.org/10.1016/s1474-4422(21)00361-6	PROPN
fnp-3806	4383	2	jansen	jansen	PROPN
fnp-3806	4383	3	wj	wj	PROPN
fnp-3806	4383	4	,	,	PUNCT
fnp-3806	4383	5	ossenkoppele	ossenkoppele	PROPN
fnp-3806	4383	6	r	r	PROPN
fnp-3806	4383	7	,	,	PUNCT
fnp-3806	4383	8	knol	knol	PROPN
fnp-3806	4383	9	dl	dl	PROPN
fnp-3806	4383	10	,	,	PUNCT
fnp-3806	4383	11	et	et	PROPN
fnp-3806	4383	12	al	al	PROPN
fnp-3806	4383	13	.	.	PUNCT
fnp-3806	4384	1	prevalence	prevalence	NOUN
fnp-3806	4384	2	of	of	ADP
fnp-3806	4384	3	cerebral	cerebral	ADJ
fnp-3806	4384	4	amyloid	amyloid	NOUN
fnp-3806	4384	5	pathology	pathology	NOUN
fnp-3806	4384	6	in	in	ADP
fnp-3806	4384	7	persons	person	NOUN
fnp-3806	4384	8	without	without	ADP
fnp-3806	4384	9	dementia	dementia	NOUN
fnp-3806	4384	10	:	:	PUNCT
fnp-3806	4384	11	a	a	DET
fnp-3806	4384	12	meta	meta	ADJ
fnp-3806	4384	13	-	-	PUNCT
fnp-3806	4384	14	analysis	analysis	NOUN
fnp-3806	4384	15	.	.	PUNCT
fnp-3806	4385	1	jama	jama	PROPN
fnp-3806	4385	2	2015;313:1924	2015;313:1924	NUM
fnp-3806	4385	3	-	-	SYM
fnp-3806	4385	4	1938	1938	NUM
fnp-3806	4385	5	.	.	PUNCT
fnp-3806	4386	1	https://doi.org/10.1001/jama.2015.4668	https://doi.org/10.1001/jama.2015.4668	PROPN
fnp-3806	4386	2	jansen	jansen	PROPN
fnp-3806	4386	3	wj	wj	PROPN
fnp-3806	4386	4	,	,	PUNCT
fnp-3806	4386	5	janssen	janssen	PROPN
fnp-3806	4386	6	o	o	PROPN
fnp-3806	4386	7	,	,	PUNCT
fnp-3806	4386	8	tijms	tijms	PROPN
fnp-3806	4386	9	bm	bm	PROPN
fnp-3806	4386	10	,	,	PUNCT
fnp-3806	4386	11	et	et	PROPN
fnp-3806	4386	12	al	al	PROPN
fnp-3806	4386	13	.	.	PUNCT
fnp-3806	4387	1	prevalence	prevalence	NOUN
fnp-3806	4387	2	estimates	estimate	NOUN
fnp-3806	4387	3	of	of	ADP
fnp-3806	4387	4	amyloid	amyloid	NOUN
fnp-3806	4387	5	abnormality	abnormality	NOUN
fnp-3806	4387	6	across	across	ADP
fnp-3806	4387	7	the	the	DET
fnp-3806	4387	8	alzheimer	alzheimer	PROPN
fnp-3806	4387	9	disease	disease	PROPN
fnp-3806	4387	10	clinical	clinical	ADJ
fnp-3806	4387	11	spectrum	spectrum	NOUN
fnp-3806	4387	12	.	.	PUNCT
fnp-3806	4388	1	jama	jama	PROPN
fnp-3806	4388	2	neurol	neurol	PROPN
fnp-3806	4388	3	2022;79:228	2022;79:228	PROPN
fnp-3806	4388	4	-	-	SYM
fnp-3806	4388	5	243	243	NUM
fnp-3806	4388	6	.	.	PUNCT
fnp-3806	4389	1	https://doi.org/10.1001/jamaneurol.2021.5216	https://doi.org/10.1001/jamaneurol.2021.5216	VERB
fnp-3806	4389	2	okamura	okamura	PRON
fnp-3806	4389	3	n	n	CCONJ
fnp-3806	4389	4	,	,	PUNCT
fnp-3806	4389	5	harada	harada	PROPN
fnp-3806	4389	6	r	r	PROPN
fnp-3806	4389	7	,	,	PUNCT
fnp-3806	4389	8	furumoto	furumoto	PROPN
fnp-3806	4389	9	s	s	PROPN
fnp-3806	4389	10	,	,	PUNCT
fnp-3806	4389	11	et	et	PROPN
fnp-3806	4389	12	al	al	PROPN
fnp-3806	4389	13	.	.	PUNCT
fnp-3806	4390	1	tau	tau	PROPN
fnp-3806	4390	2	pet	pet	PROPN
fnp-3806	4390	3	imaging	imaging	NOUN
fnp-3806	4390	4	in	in	ADP
fnp-3806	4390	5	alzheimer	alzheimer	PROPN
fnp-3806	4390	6	's	's	PART
fnp-3806	4390	7	disease	disease	NOUN
fnp-3806	4390	8	.	.	PUNCT
fnp-3806	4391	1	curr	curr	PROPN
fnp-3806	4391	2	neurol	neurol	PROPN
fnp-3806	4391	3	neurosci	neurosci	PROPN
fnp-3806	4391	4	rep	rep	PROPN
fnp-3806	4391	5	2014;14:500	2014;14:500	PROPN
fnp-3806	4391	6	.	.	PUNCT
fnp-3806	4392	1	https://doi.org/10.1007/s11910-014-0500-6	https://doi.org/10.1007/s11910-014-0500-6	PROPN
fnp-3806	4392	2	schöll	schöll	PROPN
fnp-3806	4392	3	m	m	PROPN
fnp-3806	4392	4	,	,	PUNCT
fnp-3806	4392	5	lockhart	lockhart	PROPN
fnp-3806	4392	6	sn	sn	PROPN
fnp-3806	4392	7	,	,	PUNCT
fnp-3806	4392	8	schonhaut	schonhaut	PROPN
fnp-3806	4392	9	dr	dr	PROPN
fnp-3806	4392	10	,	,	PUNCT
fnp-3806	4392	11	et	et	PROPN
fnp-3806	4392	12	al	al	PROPN
fnp-3806	4392	13	.	.	PROPN
fnp-3806	4392	14	pet	pet	PROPN
fnp-3806	4392	15	imaging	imaging	NOUN
fnp-3806	4392	16	of	of	ADP
fnp-3806	4392	17	tau	tau	PROPN
fnp-3806	4392	18	deposition	deposition	NOUN
fnp-3806	4392	19	in	in	ADP
fnp-3806	4392	20	the	the	DET
fnp-3806	4392	21	aging	age	VERB
fnp-3806	4392	22	human	human	ADJ
fnp-3806	4392	23	brain	brain	NOUN
fnp-3806	4392	24	.	.	PUNCT
fnp-3806	4393	1	neuron	neuron	PROPN
fnp-3806	4393	2	2016;89:971	2016;89:971	PROPN
fnp-3806	4393	3	-	-	SYM
fnp-3806	4393	4	982	982	NUM
fnp-3806	4393	5	.	.	PUNCT
fnp-3806	4394	1	https://doi.org/10.1007/s11910-014-0500-6	https://doi.org/10.1007/s11910-014-0500-6	PROPN
fnp-3806	4394	2	lockhart	lockhart	PROPN
fnp-3806	4394	3	sn	sn	PROPN
fnp-3806	4394	4	,	,	PUNCT
fnp-3806	4394	5	baker	baker	PROPN
fnp-3806	4394	6	sl	sl	PROPN
fnp-3806	4394	7	,	,	PUNCT
fnp-3806	4394	8	okamura	okamura	NOUN
fnp-3806	4394	9	n	n	NOUN
fnp-3806	4394	10	,	,	PUNCT
fnp-3806	4394	11	et	et	PROPN
fnp-3806	4394	12	al	al	PROPN
fnp-3806	4394	13	.	.	PUNCT
fnp-3806	4394	14	dynamic	dynamic	ADJ
fnp-3806	4394	15	pet	pet	ADJ
fnp-3806	4394	16	measures	measure	NOUN
fnp-3806	4394	17	of	of	ADP
fnp-3806	4394	18	tau	tau	PROPN
fnp-3806	4394	19	accumulation	accumulation	NOUN
fnp-3806	4394	20	in	in	ADP
fnp-3806	4394	21	cognitively	cognitively	ADV
fnp-3806	4394	22	normal	normal	ADJ
fnp-3806	4394	23	older	old	ADJ
fnp-3806	4394	24	adults	adult	NOUN
fnp-3806	4394	25	and	and	CCONJ
fnp-3806	4394	26	alzheimer	alzheimer	PROPN
fnp-3806	4394	27	’s	’s	PART
fnp-3806	4394	28	disease	disease	NOUN
fnp-3806	4394	29	patients	patient	NOUN
fnp-3806	4394	30	measured	measure	VERB
fnp-3806	4394	31	using	use	VERB
fnp-3806	4394	32	[	[	X
fnp-3806	4394	33	18f	18f	NUM
fnp-3806	4394	34	]	]	PUNCT
fnp-3806	4394	35	thk-5351	thk-5351	NOUN
fnp-3806	4394	36	.	.	PUNCT
fnp-3806	4395	1	plos	plos	PROPN
fnp-3806	4395	2	one	one	NUM
fnp-3806	4395	3	2016;11	2016;11	NOUN
fnp-3806	4395	4	:	:	PUNCT
fnp-3806	4395	5	e0158460	e0158460	PROPN
fnp-3806	4395	6	.	.	PUNCT
fnp-3806	4396	1	https://doi.org/10.1371/journal.pone.0158460	https://doi.org/10.1371/journal.pone.0158460	PROPN
fnp-3806	4397	1	maass	maass	PROPN
fnp-3806	4397	2	a	a	PROPN
fnp-3806	4397	3	,	,	PUNCT
fnp-3806	4397	4	landau	landau	NOUN
fnp-3806	4397	5	s	s	PROPN
fnp-3806	4397	6	,	,	PUNCT
fnp-3806	4397	7	baker	baker	PROPN
fnp-3806	4397	8	sl	sl	PROPN
fnp-3806	4397	9	,	,	PUNCT
fnp-3806	4397	10	et	et	PROPN
fnp-3806	4397	11	al	al	PROPN
fnp-3806	4397	12	.	.	PROPN
fnp-3806	4397	13	comparison	comparison	NOUN
fnp-3806	4397	14	of	of	ADP
fnp-3806	4397	15	multiple	multiple	ADJ
fnp-3806	4397	16	tau	tau	ADJ
fnp-3806	4397	17	-	-	PUNCT
fnp-3806	4397	18	pet	pet	ADJ
fnp-3806	4397	19	measures	measure	NOUN
fnp-3806	4397	20	as	as	ADP
fnp-3806	4397	21	biomarkers	biomarker	NOUN
fnp-3806	4397	22	in	in	ADP
fnp-3806	4397	23	aging	aging	NOUN
fnp-3806	4397	24	and	and	CCONJ
fnp-3806	4397	25	alzheimer	alzheimer	PROPN
fnp-3806	4397	26	’s	’s	PART
fnp-3806	4397	27	disease	disease	NOUN
fnp-3806	4397	28	.	.	PUNCT
fnp-3806	4398	1	neuroimage	neuroimage	NOUN
fnp-3806	4398	2	2017	2017	NUM
fnp-3806	4398	3	;	;	PUNCT
fnp-3806	4398	4	157:448	157:448	NOUN
fnp-3806	4398	5	-	-	SYM
fnp-3806	4398	6	463	463	NUM
fnp-3806	4398	7	.	.	PUNCT
fnp-3806	4399	1	https://doi.org/10.1016/j.neuroimage.2017.05.058	https://doi.org/10.1016/j.neuroimage.2017.05.058	VERB
fnp-3806	4399	2	chotipanich	chotipanich	ADJ
fnp-3806	4399	3	c	c	X
fnp-3806	4399	4	,	,	PUNCT
fnp-3806	4399	5	jantarato	jantarato	PROPN
fnp-3806	4399	6	a	a	PRON
fnp-3806	4399	7	,	,	PUNCT
fnp-3806	4399	8	kunawudhi	kunawudhi	VERB
fnp-3806	4399	9	a	a	PRON
fnp-3806	4399	10	,	,	PUNCT
fnp-3806	4399	11	et	et	PROPN
fnp-3806	4399	12	al	al	PROPN
fnp-3806	4399	13	.	.	PROPN
fnp-3806	4399	14	11c	11c	NOUN
fnp-3806	4399	15	-	-	PUNCT
fnp-3806	4399	16	pittsburgh	pittsburgh	PROPN
fnp-3806	4399	17	compound	compound	PROPN
fnp-3806	4399	18	b	b	PROPN
fnp-3806	4399	19	and	and	CCONJ
fnp-3806	4399	20	18f	18f	NUM
fnp-3806	4399	21	-	-	PUNCT
fnp-3806	4399	22	thk	thk	PROPN
fnp-3806	4399	23	5351	5351	NUM
fnp-3806	4399	24	positron	positron	NOUN
fnp-3806	4399	25	emission	emission	NOUN
fnp-3806	4399	26	tomography	tomography	NOUN
fnp-3806	4399	27	brain	brain	NOUN
fnp-3806	4399	28	imaging	imaging	NOUN
fnp-3806	4399	29	in	in	ADP
fnp-3806	4399	30	cognitively	cognitively	ADV
fnp-3806	4399	31	normal	normal	ADJ
fnp-3806	4399	32	individuals	individual	NOUN
fnp-3806	4399	33	.	.	PUNCT
fnp-3806	4400	1	world	world	PROPN
fnp-3806	4400	2	j	j	PROPN
fnp-3806	4400	3	nucl	nucl	PROPN
fnp-3806	4400	4	med	me	VERB
fnp-3806	4400	5	2020;20:133	2020;20:133	PROPN
fnp-3806	4400	6	-	-	SYM
fnp-3806	4400	7	138	138	NUM
fnp-3806	4400	8	.	.	PUNCT
fnp-3806	4401	1	https://doi.org/10.4103/wjnm.wjnm_57_20	https://doi.org/10.4103/wjnm.wjnm_57_20	PROPN
fnp-3806	4401	2	mueller	mueller	PROPN
fnp-3806	4401	3	a	a	PROPN
fnp-3806	4401	4	,	,	PUNCT
fnp-3806	4401	5	bullich	bullich	NOUN
fnp-3806	4401	6	s	s	PART
fnp-3806	4401	7	,	,	PUNCT
fnp-3806	4401	8	barret	barret	ADJ
fnp-3806	4401	9	o	o	NOUN
fnp-3806	4401	10	,	,	PUNCT
fnp-3806	4401	11	et	et	PROPN
fnp-3806	4401	12	al	al	PROPN
fnp-3806	4401	13	.	.	PUNCT
fnp-3806	4402	1	tau	tau	PROPN
fnp-3806	4402	2	pet	pet	PROPN
fnp-3806	4402	3	imaging	imaging	NOUN
fnp-3806	4402	4	with	with	ADP
fnp-3806	4402	5	18f	18f	NOUN
fnp-3806	4402	6	-	-	PUNCT
fnp-3806	4402	7	pi-2620	pi-2620	NOUN
fnp-3806	4402	8	in	in	ADP
fnp-3806	4402	9	patients	patient	NOUN
fnp-3806	4402	10	with	with	ADP
fnp-3806	4402	11	alzheimer	alzheimer	PROPN
fnp-3806	4402	12	disease	disease	NOUN
fnp-3806	4402	13	and	and	CCONJ
fnp-3806	4402	14	healthy	healthy	ADJ
fnp-3806	4402	15	controls	control	NOUN
fnp-3806	4402	16	:	:	PUNCT
fnp-3806	4402	17	a	a	DET
fnp-3806	4402	18	first	first	ADJ
fnp-3806	4402	19	-	-	PUNCT
fnp-3806	4402	20	in	in	ADP
fnp-3806	4402	21	-	-	PUNCT
fnp-3806	4402	22	humans	human	NOUN
fnp-3806	4402	23	study	study	NOUN
fnp-3806	4402	24	.	.	PUNCT
fnp-3806	4403	1	j	j	PROPN
fnp-3806	4403	2	nucl	nucl	PROPN
fnp-3806	4403	3	med	me	VERB
fnp-3806	4403	4	2020;61:911	2020;61:911	PROPN
fnp-3806	4403	5	-	-	SYM
fnp-3806	4403	6	919	919	NUM
fnp-3806	4403	7	.	.	PUNCT
fnp-3806	4404	1	https://doi.org/10.2967/jnumed.119.236224	https://doi.org/10.2967/jnumed.119.236224	VERB
fnp-3806	4404	2	sintini	sintini	PROPN
fnp-3806	4404	3	i	i	PROPN
fnp-3806	4404	4	,	,	PUNCT
fnp-3806	4404	5	whitwell	whitwell	VERB
fnp-3806	4404	6	jl	jl	PROPN
fnp-3806	4404	7	.	.	PUNCT
fnp-3806	4404	8	update	update	NOUN
fnp-3806	4404	9	on	on	ADP
fnp-3806	4404	10	neuroimaging	neuroimage	VERB
fnp-3806	4404	11	in	in	ADP
fnp-3806	4404	12	alzheimer	alzheimer	PROPN
fnp-3806	4404	13	's	's	PART
fnp-3806	4404	14	disease	disease	NOUN
fnp-3806	4404	15	.	.	PUNCT
fnp-3806	4405	1	curr	curr	PROPN
fnp-3806	4405	2	opin	opin	PROPN
fnp-3806	4405	3	neurol	neurol	PROPN
fnp-3806	4405	4	2021;34:525	2021;34:525	PROPN
fnp-3806	4405	5	-	-	PUNCT
fnp-3806	4405	6	531	531	NUM
fnp-3806	4405	7	.	.	PUNCT
fnp-3806	4406	1	https://doi.org/10.1097/wco.0000000000000947	https://doi.org/10.1097/wco.0000000000000947	ADJ
fnp-3806	4406	2	ossenkoppele	ossenkoppele	PROPN
fnp-3806	4406	3	r	r	PROPN
fnp-3806	4406	4	,	,	PUNCT
fnp-3806	4406	5	smith	smith	PROPN
fnp-3806	4406	6	r	r	PROPN
fnp-3806	4406	7	,	,	PUNCT
fnp-3806	4406	8	mattsson	mattsson	PROPN
fnp-3806	4406	9	-	-	PUNCT
fnp-3806	4406	10	carlgren	carlgren	PROPN
fnp-3806	4406	11	n	n	CCONJ
fnp-3806	4406	12	,	,	PUNCT
fnp-3806	4406	13	et	et	PROPN
fnp-3806	4406	14	al	al	PROPN
fnp-3806	4406	15	.	.	PROPN
fnp-3806	4406	16	accuracy	accuracy	NOUN
fnp-3806	4406	17	of	of	ADP
fnp-3806	4406	18	tau	tau	PROPN
fnp-3806	4406	19	positron	positron	NOUN
fnp-3806	4406	20	emission	emission	NOUN
fnp-3806	4406	21	tomography	tomography	NOUN
fnp-3806	4406	22	as	as	ADP
fnp-3806	4406	23	a	a	DET
fnp-3806	4406	24	prognostic	prognostic	ADJ
fnp-3806	4406	25	marker	marker	NOUN
fnp-3806	4406	26	in	in	ADP
fnp-3806	4406	27	preclinical	preclinical	ADJ
fnp-3806	4406	28	and	and	CCONJ
fnp-3806	4406	29	prodromal	prodromal	ADJ
fnp-3806	4406	30	alzheimer	alzheimer	NOUN
fnp-3806	4406	31	disease	disease	NOUN
fnp-3806	4406	32	:	:	PUNCT
fnp-3806	4406	33	a	a	DET
fnp-3806	4406	34	head	head	NOUN
fnp-3806	4406	35	-	-	PUNCT
fnp-3806	4406	36	to	to	ADP
fnp-3806	4406	37	-	-	PUNCT
fnp-3806	4406	38	head	head	NOUN
fnp-3806	4406	39	comparison	comparison	NOUN
fnp-3806	4406	40	against	against	ADP
fnp-3806	4406	41	amyloid	amyloid	NOUN
fnp-3806	4406	42	positron	positron	NOUN
fnp-3806	4406	43	emission	emission	NOUN
fnp-3806	4406	44	tomography	tomography	NOUN
fnp-3806	4406	45	and	and	CCONJ
fnp-3806	4406	46	magnetic	magnetic	ADJ
fnp-3806	4406	47	resonance	resonance	NOUN
fnp-3806	4406	48	imaging	imaging	NOUN
fnp-3806	4406	49	.	.	PUNCT
fnp-3806	4407	1	jama	jama	PROPN
fnp-3806	4407	2	neurol	neurol	PROPN
fnp-3806	4407	3	2021;78:961	2021;78:961	PROPN
fnp-3806	4407	4	-	-	PUNCT
fnp-3806	4407	5	971	971	NUM
fnp-3806	4407	6	.	.	PUNCT
fnp-3806	4408	1	https://doi.org/10.1001/jamaneurol.2021.1858	https://doi.org/10.1001/jamaneurol.2021.1858	PROPN
fnp-3806	4408	2	jack	jack	PROPN
fnp-3806	4408	3	cr	cr	PROPN
fnp-3806	4408	4	,	,	PUNCT
fnp-3806	4408	5	wiste	wiste	PROPN
fnp-3806	4408	6	hj	hj	PROPN
fnp-3806	4408	7	,	,	PUNCT
fnp-3806	4408	8	weigand	weigand	NOUN
fnp-3806	4408	9	sd	sd	NOUN
fnp-3806	4408	10	,	,	PUNCT
fnp-3806	4408	11	et	et	PROPN
fnp-3806	4408	12	al	al	PROPN
fnp-3806	4408	13	.	.	PUNCT
fnp-3806	4408	14	age	age	NOUN
fnp-3806	4408	15	-	-	PUNCT
fnp-3806	4408	16	specific	specific	ADJ
fnp-3806	4408	17	and	and	CCONJ
fnp-3806	4408	18	sex	sex	NOUN
fnp-3806	4408	19	-	-	PUNCT
fnp-3806	4408	20	specific	specific	ADJ
fnp-3806	4408	21	prevalence	prevalence	NOUN
fnp-3806	4408	22	of	of	ADP
fnp-3806	4408	23	cerebral	cerebral	ADJ
fnp-3806	4408	24	β	β	NOUN
fnp-3806	4408	25	-	-	NOUN
fnp-3806	4408	26	amyloidosis	amyloidosis	NOUN
fnp-3806	4408	27	,	,	PUNCT
fnp-3806	4408	28	tauopathy	tauopathy	ADJ
fnp-3806	4408	29	,	,	PUNCT
fnp-3806	4408	30	and	and	CCONJ
fnp-3806	4408	31	neurodegeneration	neurodegeneration	NOUN
fnp-3806	4408	32	in	in	ADP
fnp-3806	4408	33	cognitively	cognitively	ADV
fnp-3806	4408	34	unimpaired	unimpaired	ADJ
fnp-3806	4408	35	individuals	individual	NOUN
fnp-3806	4408	36	aged	age	VERB
fnp-3806	4408	37	50	50	NUM
fnp-3806	4408	38	-	-	SYM
fnp-3806	4408	39	95	95	NUM
fnp-3806	4408	40	years	year	NOUN
fnp-3806	4408	41	:	:	PUNCT
fnp-3806	4408	42	a	a	DET
fnp-3806	4408	43	cross	cross	ADJ
fnp-3806	4408	44	-	-	ADJ
fnp-3806	4408	45	sectional	sectional	ADJ
fnp-3806	4408	46	study	study	NOUN
fnp-3806	4408	47	.	.	PUNCT
fnp-3806	4409	1	lancet	lancet	PROPN
fnp-3806	4409	2	neurol	neurol	PROPN
fnp-3806	4409	3	2017;16:435	2017;16:435	NOUN
fnp-3806	4409	4	-	-	SYM
fnp-3806	4409	5	444	444	NUM
fnp-3806	4409	6	.	.	PUNCT
fnp-3806	4410	1	https://doi.org/10.1016/s1474-4422(17)30077-7	https://doi.org/10.1016/s1474-4422(17)30077-7	PROPN
fnp-3806	4410	2	lowe	lowe	PROPN
fnp-3806	4410	3	vj	vj	PROPN
fnp-3806	4410	4	,	,	PUNCT
fnp-3806	4410	5	wiste	wiste	PROPN
fnp-3806	4410	6	hj	hj	PROPN
fnp-3806	4410	7	,	,	PUNCT
fnp-3806	4410	8	senjem	senjem	NOUN
fnp-3806	4410	9	ml	ml	PROPN
fnp-3806	4410	10	,	,	PUNCT
fnp-3806	4410	11	et	et	PROPN
fnp-3806	4410	12	al	al	PROPN
fnp-3806	4410	13	.	.	PROPN
fnp-3806	4411	1	widespread	widespread	ADJ
fnp-3806	4411	2	brain	brain	NOUN
fnp-3806	4411	3	tau	tau	PROPN
fnp-3806	4411	4	and	and	CCONJ
fnp-3806	4411	5	its	its	PRON
fnp-3806	4411	6	association	association	NOUN
fnp-3806	4411	7	with	with	ADP
fnp-3806	4411	8	ageing	age	VERB
fnp-3806	4411	9	,	,	PUNCT
fnp-3806	4411	10	braak	braak	NOUN
fnp-3806	4411	11	stage	stage	NOUN
fnp-3806	4411	12	and	and	CCONJ
fnp-3806	4411	13	alzheimer	alzheimer	PROPN
fnp-3806	4411	14	's	's	PART
fnp-3806	4411	15	dementia	dementia	NOUN
fnp-3806	4411	16	.	.	PUNCT
fnp-3806	4412	1	brain	brain	NOUN
fnp-3806	4412	2	2018;141:271	2018;141:271	NOUN
fnp-3806	4412	3	-	-	SYM
fnp-3806	4412	4	287	287	NUM
fnp-3806	4412	5	.	.	PUNCT
fnp-3806	4413	1	https://doi.org/10.1093/brain/awx320	https://doi.org/10.1093/brain/awx320	NOUN
fnp-3806	4413	2	yoon	yoon	PROPN
fnp-3806	4413	3	b	b	PROPN
fnp-3806	4413	4	,	,	PUNCT
fnp-3806	4413	5	guo	guo	PROPN
fnp-3806	4413	6	t	t	PROPN
fnp-3806	4413	7	,	,	PUNCT
fnp-3806	4413	8	provost	provost	NOUN
fnp-3806	4413	9	k	k	NOUN
fnp-3806	4413	10	,	,	PUNCT
fnp-3806	4413	11	et	et	PROPN
fnp-3806	4413	12	al	al	PROPN
fnp-3806	4413	13	.	.	PROPN
fnp-3806	4413	14	abnormal	abnormal	PROPN
fnp-3806	4413	15	tau	tau	PROPN
fnp-3806	4413	16	in	in	ADP
fnp-3806	4413	17	amyloid	amyloid	PROPN
fnp-3806	4413	18	pet	pet	ADJ
fnp-3806	4413	19	negative	negative	ADJ
fnp-3806	4413	20	individuals	individual	NOUN
fnp-3806	4413	21	.	.	PUNCT
fnp-3806	4414	1	neurobiol	neurobiol	PROPN
fnp-3806	4414	2	aging	age	VERB
fnp-3806	4414	3	2022;109:125	2022;109:125	NUM
fnp-3806	4414	4	-	-	SYM
fnp-3806	4414	5	134	134	NUM
fnp-3806	4414	6	.	.	PUNCT
fnp-3806	4415	1	https://doi.org/10.1016/j.neurobiolaging.2021.09.019	https://doi.org/10.1016/j.neurobiolaging.2021.09.019	PROPN
fnp-3806	4415	2	groot	groot	PROPN
fnp-3806	4415	3	c	c	X
fnp-3806	4415	4	,	,	PUNCT
fnp-3806	4415	5	doré	doré	PROPN
fnp-3806	4415	6	v	v	PROPN
fnp-3806	4415	7	,	,	PUNCT
fnp-3806	4415	8	robertson	robertson	PROPN
fnp-3806	4415	9	j	j	PROPN
fnp-3806	4415	10	,	,	PUNCT
fnp-3806	4415	11	et	et	PROPN
fnp-3806	4415	12	al	al	PROPN
fnp-3806	4415	13	.	.	PROPN
fnp-3806	4416	1	mesial	mesial	ADJ
fnp-3806	4416	2	temporal	temporal	ADJ
fnp-3806	4416	3	tau	tau	PROPN
fnp-3806	4416	4	is	be	AUX
fnp-3806	4416	5	related	relate	VERB
fnp-3806	4416	6	to	to	ADP
fnp-3806	4416	7	worse	bad	ADJ
fnp-3806	4416	8	cognitive	cognitive	ADJ
fnp-3806	4416	9	performance	performance	NOUN
fnp-3806	4416	10	and	and	CCONJ
fnp-3806	4416	11	greater	great	ADJ
fnp-3806	4416	12	neocortical	neocortical	ADJ
fnp-3806	4416	13	tau	tau	NOUN
fnp-3806	4416	14	load	load	NOUN
fnp-3806	4416	15	in	in	ADP
fnp-3806	4416	16	amyloid	amyloid	NOUN
fnp-3806	4416	17	-	-	PUNCT
fnp-3806	4416	18	beta	beta	NOUN
fnp-3806	4416	19	-	-	PUNCT
fnp-3806	4416	20	negative	negative	ADJ
fnp-3806	4416	21	cognitively	cognitively	ADV
fnp-3806	4416	22	normal	normal	ADJ
fnp-3806	4416	23	individuals	individual	NOUN
fnp-3806	4416	24	.	.	PUNCT
fnp-3806	4417	1	neurobiol	neurobiol	ADJ
fnp-3806	4417	2	aging	age	VERB
fnp-3806	4417	3	2021;97:41	2021;97:41	NUM
fnp-3806	4417	4	-	-	SYM
fnp-3806	4417	5	48	48	NUM
fnp-3806	4417	6	.	.	PUNCT
fnp-3806	4418	1	https://doi.org/10.1016/j.neurobiolaging.2020.09.017	https://doi.org/10.1016/j.neurobiolaging.2020.09.017	PROPN
fnp-3806	4418	2	wisse	wisse	PROPN
fnp-3806	4418	3	lem	lem	PROPN
fnp-3806	4418	4	,	,	PUNCT
fnp-3806	4418	5	xie	xie	PROPN
fnp-3806	4418	6	l	l	PROPN
fnp-3806	4418	7	,	,	PUNCT
fnp-3806	4418	8	das	das	PROPN
fnp-3806	4418	9	sr	sr	PROPN
fnp-3806	4418	10	,	,	PUNCT
fnp-3806	4418	11	et	et	PROPN
fnp-3806	4418	12	al	al	PROPN
fnp-3806	4418	13	.	.	PUNCT
fnp-3806	4419	1	tau	tau	PROPN
fnp-3806	4419	2	pathology	pathology	NOUN
fnp-3806	4419	3	mediates	mediate	VERB
fnp-3806	4419	4	age	age	NOUN
fnp-3806	4419	5	effects	effect	NOUN
fnp-3806	4419	6	on	on	ADP
fnp-3806	4419	7	medial	medial	ADJ
fnp-3806	4419	8	temporal	temporal	ADJ
fnp-3806	4419	9	lobe	lobe	NOUN
fnp-3806	4419	10	structure	structure	NOUN
fnp-3806	4419	11	.	.	PUNCT
fnp-3806	4420	1	neurobiol	neurobiol	ADJ
fnp-3806	4420	2	aging	age	VERB
fnp-3806	4420	3	2022;109:135	2022;109:135	NUM
fnp-3806	4420	4	-	-	SYM
fnp-3806	4420	5	144	144	NUM
fnp-3806	4420	6	.	.	PUNCT
fnp-3806	4421	1	https://doi.org/10.1016/j.neurobiolaging.2021.09.017	https://doi.org/10.1016/j.neurobiolaging.2021.09.017	PROPN
fnp-3806	4421	2	chen	chen	PROPN
fnp-3806	4421	3	sd	sd	PROPN
fnp-3806	4421	4	,	,	PUNCT
fnp-3806	4421	5	lu	lu	PROPN
fnp-3806	4421	6	jy	jy	PROPN
fnp-3806	4421	7	,	,	PUNCT
fnp-3806	4421	8	li	li	PROPN
fnp-3806	4421	9	hq	hq	PROPN
fnp-3806	4421	10	,	,	PUNCT
fnp-3806	4421	11	et	et	PROPN
fnp-3806	4421	12	al	al	PROPN
fnp-3806	4421	13	.	.	PROPN
fnp-3806	4421	14	staging	stage	VERB
fnp-3806	4421	15	tau	tau	PROPN
fnp-3806	4421	16	pathology	pathology	NOUN
fnp-3806	4421	17	with	with	ADP
fnp-3806	4421	18	tau	tau	PROPN
fnp-3806	4421	19	pet	pet	NOUN
fnp-3806	4421	20	in	in	ADP
fnp-3806	4421	21	alzheimer	alzheimer	PROPN
fnp-3806	4421	22	's	's	PART
fnp-3806	4421	23	disease	disease	NOUN
fnp-3806	4421	24	:	:	PUNCT
fnp-3806	4421	25	a	a	DET
fnp-3806	4421	26	longitudinal	longitudinal	ADJ
fnp-3806	4421	27	study	study	NOUN
fnp-3806	4421	28	.	.	PUNCT
fnp-3806	4422	1	transl	transl	PROPN
fnp-3806	4422	2	psychiatry	psychiatry	PROPN
fnp-3806	4422	3	2021;11:483	2021;11:483	PROPN
fnp-3806	4422	4	.	.	PUNCT
fnp-3806	4423	1	https://doi.org/10.1038/s41398-021-01602-5	https://doi.org/10.1038/s41398-021-01602-5	NUM
fnp-3806	4423	2	rubinski	rubinski	NOUN
fnp-3806	4423	3	a	a	NOUN
fnp-3806	4423	4	,	,	PUNCT
fnp-3806	4423	5	tosun	tosun	NOUN
fnp-3806	4423	6	d	d	NOUN
fnp-3806	4423	7	,	,	PUNCT
fnp-3806	4423	8	franzmeier	franzmeier	NOUN
fnp-3806	4423	9	n	n	CCONJ
fnp-3806	4423	10	,	,	PUNCT
fnp-3806	4423	11	et	et	PROPN
fnp-3806	4423	12	al	al	PROPN
fnp-3806	4423	13	.	.	PROPN
fnp-3806	4424	1	lower	low	ADJ
fnp-3806	4424	2	cerebral	cerebral	ADJ
fnp-3806	4424	3	perfusion	perfusion	NOUN
fnp-3806	4424	4	is	be	AUX
fnp-3806	4424	5	associated	associate	VERB
fnp-3806	4424	6	with	with	ADP
fnp-3806	4424	7	tau	tau	NOUN
fnp-3806	4424	8	-	-	PUNCT
fnp-3806	4424	9	pet	pet	NOUN
fnp-3806	4424	10	in	in	ADP
fnp-3806	4424	11	the	the	DET
fnp-3806	4424	12	entorhinal	entorhinal	ADJ
fnp-3806	4424	13	cortex	cortex	NOUN
fnp-3806	4424	14	across	across	ADP
fnp-3806	4424	15	the	the	DET
fnp-3806	4424	16	alzheimer	alzheimer	NOUN
fnp-3806	4424	17	's	's	PART
fnp-3806	4424	18	continuum	continuum	PROPN
fnp-3806	4424	19	.	.	PUNCT
fnp-3806	4425	1	neurobiol	neurobiol	PROPN
fnp-3806	4425	2	aging	age	VERB
fnp-3806	4425	3	2021;102:111	2021;102:111	NUM
fnp-3806	4425	4	-	-	SYM
fnp-3806	4425	5	118	118	NUM
fnp-3806	4425	6	.	.	PUNCT
fnp-3806	4426	1	https://doi.org/10.1016/j.neurobiolaging.2021.02.003	https://doi.org/10.1016/j.neurobiolaging.2021.02.003	PROPN
fnp-3806	4426	2	berron	berron	NOUN
fnp-3806	4426	3	d	d	NOUN
fnp-3806	4426	4	,	,	PUNCT
fnp-3806	4426	5	vogel	vogel	PROPN
fnp-3806	4426	6	jw	jw	PROPN
fnp-3806	4426	7	,	,	PUNCT
fnp-3806	4426	8	insel	insel	PROPN
fnp-3806	4426	9	ps	ps	PROPN
fnp-3806	4426	10	,	,	PUNCT
fnp-3806	4426	11	et	et	PROPN
fnp-3806	4426	12	al	al	PROPN
fnp-3806	4426	13	.	.	PUNCT
fnp-3806	4427	1	early	early	ADJ
fnp-3806	4427	2	stages	stage	NOUN
fnp-3806	4427	3	of	of	ADP
fnp-3806	4427	4	tau	tau	PROPN
fnp-3806	4427	5	pathology	pathology	NOUN
fnp-3806	4427	6	and	and	CCONJ
fnp-3806	4427	7	its	its	PRON
fnp-3806	4427	8	associations	association	NOUN
fnp-3806	4427	9	with	with	ADP
fnp-3806	4427	10	functional	functional	ADJ
fnp-3806	4427	11	connectivity	connectivity	NOUN
fnp-3806	4427	12	,	,	PUNCT
fnp-3806	4427	13	atrophy	atrophy	NOUN
fnp-3806	4427	14	and	and	CCONJ
fnp-3806	4427	15	memory	memory	NOUN
fnp-3806	4427	16	.	.	PUNCT
fnp-3806	4428	1	brain	brain	PROPN
fnp-3806	4428	2	2021;144:2771	2021;144:2771	NUM
fnp-3806	4428	3	-	-	SYM
fnp-3806	4428	4	2783	2783	NUM
fnp-3806	4428	5	.	.	PUNCT
fnp-3806	4429	1	https://doi.org/10.1093/brain/awab114	https://doi.org/10.1093/brain/awab114	PROPN
fnp-3806	4429	2	shen	shen	PROPN
fnp-3806	4429	3	xn	xn	PROPN
fnp-3806	4429	4	,	,	PUNCT
fnp-3806	4429	5	kuo	kuo	PROPN
fnp-3806	4429	6	k	k	PROPN
fnp-3806	4429	7	,	,	PUNCT
fnp-3806	4429	8	yang	yang	PROPN
fnp-3806	4429	9	yx	yx	PROPN
fnp-3806	4429	10	,	,	PUNCT
fnp-3806	4429	11	et	et	PROPN
fnp-3806	4429	12	al	al	PROPN
fnp-3806	4429	13	.	.	PUNCT
fnp-3806	4430	1	subtle	subtle	ADJ
fnp-3806	4430	2	cognitive	cognitive	ADJ
fnp-3806	4430	3	impairment	impairment	NOUN
fnp-3806	4430	4	as	as	ADP
fnp-3806	4430	5	a	a	DET
fnp-3806	4430	6	marker	marker	NOUN
fnp-3806	4430	7	of	of	ADP
fnp-3806	4430	8	alzheimer	alzheimer	PROPN
fnp-3806	4430	9	's	's	PART
fnp-3806	4430	10	pathologies	pathology	NOUN
fnp-3806	4430	11	and	and	CCONJ
fnp-3806	4430	12	clinical	clinical	ADJ
fnp-3806	4430	13	progression	progression	NOUN
fnp-3806	4430	14	in	in	ADP
fnp-3806	4430	15	cognitively	cognitively	ADV
fnp-3806	4430	16	normal	normal	ADJ
fnp-3806	4430	17	individuals	individual	NOUN
fnp-3806	4430	18	.	.	PUNCT
fnp-3806	4431	1	alzheimers	alzheimers	PROPN
fnp-3806	4431	2	dement	dement	PROPN
fnp-3806	4431	3	2021;13	2021;13	NUM
fnp-3806	4431	4	:	:	PUNCT
fnp-3806	4431	5	e12198	e12198	ADJ
fnp-3806	4431	6	.	.	PUNCT
fnp-3806	4432	1	https://doi.org/10.1002/dad2.12198	https://doi.org/10.1002/dad2.12198	PROPN
fnp-3806	4432	2	sanchez	sanchez	PROPN
fnp-3806	4432	3	js	js	PROPN
fnp-3806	4432	4	,	,	PUNCT
fnp-3806	4432	5	becker	becker	PROPN
fnp-3806	4432	6	ja	ja	PROPN
fnp-3806	4432	7	,	,	PUNCT
fnp-3806	4432	8	jacobs	jacobs	PROPN
fnp-3806	4432	9	hil	hil	PROPN
fnp-3806	4432	10	,	,	PUNCT
fnp-3806	4432	11	et	et	PROPN
fnp-3806	4432	12	al	al	PROPN
fnp-3806	4432	13	.	.	PUNCT
fnp-3806	4433	1	the	the	DET
fnp-3806	4433	2	cortical	cortical	ADJ
fnp-3806	4433	3	origin	origin	NOUN
fnp-3806	4433	4	and	and	CCONJ
fnp-3806	4433	5	initial	initial	ADJ
fnp-3806	4433	6	spread	spread	NOUN
fnp-3806	4433	7	of	of	ADP
fnp-3806	4433	8	medial	medial	ADJ
fnp-3806	4433	9	temporal	temporal	ADJ
fnp-3806	4433	10	tauopathy	tauopathy	NOUN
fnp-3806	4433	11	in	in	ADP
fnp-3806	4433	12	alzheimer	alzheimer	PROPN
fnp-3806	4433	13	's	's	PART
fnp-3806	4433	14	disease	disease	NOUN
fnp-3806	4433	15	assessed	assess	VERB
fnp-3806	4433	16	with	with	ADP
fnp-3806	4433	17	positron	positron	NOUN
fnp-3806	4433	18	emission	emission	NOUN
fnp-3806	4433	19	tomography	tomography	NOUN
fnp-3806	4433	20	.	.	PUNCT
fnp-3806	4434	1	sci	sci	PROPN
fnp-3806	4434	2	transl	transl	PROPN
fnp-3806	4434	3	med	me	VERB
fnp-3806	4434	4	2021;13	2021;13	NUM
fnp-3806	4434	5	:	:	PUNCT
fnp-3806	4434	6	eabc0655	eabc0655	PROPN
fnp-3806	4434	7	.	.	PUNCT
fnp-3806	4435	1	https://doi.org/10.1126/scitranslmed.abc0655	https://doi.org/10.1126/scitranslmed.abc0655	PROPN
fnp-3806	4435	2	sanchez	sanchez	PROPN
fnp-3806	4435	3	js	js	PROPN
fnp-3806	4435	4	,	,	PUNCT
fnp-3806	4435	5	hanseeuw	hanseeuw	NOUN
fnp-3806	4435	6	bj	bj	NOUN
fnp-3806	4435	7	,	,	PUNCT
fnp-3806	4435	8	lopera	lopera	NOUN
fnp-3806	4435	9	f	f	PROPN
fnp-3806	4435	10	,	,	PUNCT
fnp-3806	4435	11	et	et	PROPN
fnp-3806	4435	12	al	al	PROPN
fnp-3806	4435	13	.	.	PUNCT
fnp-3806	4435	14	longitudinal	longitudinal	ADJ
fnp-3806	4435	15	amyloid	amyloid	NOUN
fnp-3806	4435	16	and	and	CCONJ
fnp-3806	4435	17	tau	tau	PROPN
fnp-3806	4435	18	accumulation	accumulation	NOUN
fnp-3806	4435	19	in	in	ADP
fnp-3806	4435	20	autosomal	autosomal	ADJ
fnp-3806	4435	21	dominant	dominant	ADJ
fnp-3806	4435	22	alzheimer	alzheimer	PROPN
fnp-3806	4435	23	's	's	PART
fnp-3806	4435	24	disease	disease	NOUN
fnp-3806	4435	25	:	:	PUNCT
fnp-3806	4435	26	findings	finding	NOUN
fnp-3806	4435	27	from	from	ADP
fnp-3806	4435	28	the	the	DET
fnp-3806	4435	29	colombia	colombia	PROPN
fnp-3806	4435	30	-	-	PUNCT
fnp-3806	4435	31	boston	boston	PROPN
fnp-3806	4435	32	(	(	PUNCT
fnp-3806	4435	33	colbos	colbos	PROPN
fnp-3806	4435	34	)	)	PUNCT
fnp-3806	4435	35	biomarker	biomarker	NOUN
fnp-3806	4435	36	study	study	NOUN
fnp-3806	4435	37	.	.	PUNCT
fnp-3806	4436	1	alzheimers	alzheimer	NOUN
fnp-3806	4436	2	res	re	VERB
fnp-3806	4436	3	ther	ther	ADV
fnp-3806	4436	4	2021;13:27	2021;13:27	NUM
fnp-3806	4436	5	.	.	PUNCT
fnp-3806	4437	1	https://doi.org/10.1186/s13195-020-00765-5	https://doi.org/10.1186/s13195-020-00765-5	PROPN
fnp-3806	4437	2	nelson	nelson	PROPN
fnp-3806	4437	3	pt	pt	PROPN
fnp-3806	4437	4	,	,	PUNCT
fnp-3806	4437	5	abner	abner	PROPN
fnp-3806	4437	6	el	el	PROPN
fnp-3806	4437	7	,	,	PUNCT
fnp-3806	4437	8	schmitt	schmitt	PROPN
fnp-3806	4437	9	fa	fa	PROPN
fnp-3806	4437	10	,	,	PUNCT
fnp-3806	4437	11	et	et	PROPN
fnp-3806	4437	12	al	al	PROPN
fnp-3806	4437	13	.	.	PROPN
fnp-3806	4437	14	brains	brain	NOUN
fnp-3806	4437	15	with	with	ADP
fnp-3806	4437	16	medial	medial	ADJ
fnp-3806	4437	17	temporal	temporal	ADJ
fnp-3806	4437	18	lobe	lobe	ADJ
fnp-3806	4437	19	neurofibrillary	neurofibrillary	ADJ
fnp-3806	4437	20	tangles	tangle	NOUN
fnp-3806	4437	21	but	but	CCONJ
fnp-3806	4437	22	no	no	DET
fnp-3806	4437	23	neuritic	neuritic	ADJ
fnp-3806	4437	24	amyloid	amyloid	NOUN
fnp-3806	4437	25	plaques	plaque	NOUN
fnp-3806	4437	26	are	be	AUX
fnp-3806	4437	27	a	a	DET
fnp-3806	4437	28	diagnostic	diagnostic	ADJ
fnp-3806	4437	29	dilemma	dilemma	NOUN
fnp-3806	4437	30	but	but	CCONJ
fnp-3806	4437	31	may	may	AUX
fnp-3806	4437	32	have	have	VERB
fnp-3806	4437	33	pathogenetic	pathogenetic	ADJ
fnp-3806	4437	34	aspects	aspect	NOUN
fnp-3806	4437	35	distinct	distinct	ADJ
fnp-3806	4437	36	from	from	ADP
fnp-3806	4437	37	alzheimer	alzheimer	PROPN
fnp-3806	4437	38	disease	disease	PROPN
fnp-3806	4437	39	.	.	PUNCT
fnp-3806	4438	1	j	j	PROPN
fnp-3806	4438	2	neuropathol	neuropathol	PROPN
fnp-3806	4438	3	exp	exp	PROPN
fnp-3806	4438	4	neurol	neurol	PROPN
fnp-3806	4438	5	2009;68:774–784	2009;68:774–784	NOUN
fnp-3806	4438	6	.	.	PUNCT
fnp-3806	4439	1	https://doi.org/10.1097/nen.0b013e3181aacbe9	https://doi.org/10.1097/nen.0b013e3181aacbe9	PROPN
fnp-3806	4439	2	crary	crary	PROPN
fnp-3806	4439	3	jf	jf	PROPN
fnp-3806	4439	4	,	,	PUNCT
fnp-3806	4439	5	trojanowski	trojanowski	PROPN
fnp-3806	4439	6	jq	jq	PROPN
fnp-3806	4439	7	,	,	PUNCT
fnp-3806	4439	8	schneider	schneider	PROPN
fnp-3806	4439	9	ja	ja	PROPN
fnp-3806	4439	10	,	,	PUNCT
fnp-3806	4439	11	et	et	PROPN
fnp-3806	4439	12	al	al	PROPN
fnp-3806	4439	13	.	.	PROPN
fnp-3806	4439	14	primary	primary	ADJ
fnp-3806	4439	15	age	age	NOUN
fnp-3806	4439	16	-	-	PUNCT
fnp-3806	4439	17	related	relate	VERB
fnp-3806	4439	18	tauopathy	tauopathy	NOUN
fnp-3806	4439	19	(	(	PUNCT
fnp-3806	4439	20	part	part	NOUN
fnp-3806	4439	21	):	):	PUNCT
fnp-3806	4439	22	a	a	DET
fnp-3806	4439	23	common	common	ADJ
fnp-3806	4439	24	pathology	pathology	NOUN
fnp-3806	4439	25	associated	associate	VERB
fnp-3806	4439	26	with	with	ADP
fnp-3806	4439	27	human	human	ADJ
fnp-3806	4439	28	aging	aging	NOUN
fnp-3806	4439	29	.	.	PUNCT
fnp-3806	4440	1	acta	acta	PROPN
fnp-3806	4440	2	neuropathol	neuropathol	PROPN
fnp-3806	4440	3	2014	2014	NUM
fnp-3806	4440	4	;	;	PUNCT
fnp-3806	4440	5	128	128	NUM
fnp-3806	4440	6	:	:	PUNCT
fnp-3806	4440	7	755	755	NUM
fnp-3806	4440	8	-	-	SYM
fnp-3806	4440	9	766	766	NUM
fnp-3806	4440	10	.	.	PUNCT
fnp-3806	4441	1	https://doi.org/10.1007/s00401-014-1349-0	https://doi.org/10.1007/s00401-014-1349-0	NUM
fnp-3806	4441	2	jellinger	jellinger	PROPN
fnp-3806	4441	3	ka	ka	PROPN
fnp-3806	4441	4	,	,	PUNCT
fnp-3806	4441	5	alafuzoff	alafuzoff	NOUN
fnp-3806	4441	6	i	i	PRON
fnp-3806	4441	7	,	,	PUNCT
fnp-3806	4441	8	attems	attem	VERB
fnp-3806	4441	9	j	j	PROPN
fnp-3806	4441	10	,	,	PUNCT
fnp-3806	4441	11	et	et	PROPN
fnp-3806	4441	12	al	al	PROPN
fnp-3806	4441	13	.	.	PROPN
fnp-3806	4441	14	part	part	PROPN
fnp-3806	4441	15	,	,	PUNCT
fnp-3806	4441	16	a	a	DET
fnp-3806	4441	17	distinct	distinct	ADJ
fnp-3806	4441	18	tauopathy	tauopathy	NOUN
fnp-3806	4441	19	,	,	PUNCT
fnp-3806	4441	20	different	different	ADJ
fnp-3806	4441	21	from	from	ADP
fnp-3806	4441	22	classical	classical	ADJ
fnp-3806	4441	23	sporadic	sporadic	ADJ
fnp-3806	4441	24	alzheimer	alzheimer	PROPN
fnp-3806	4441	25	disease	disease	NOUN
fnp-3806	4441	26	.	.	PUNCT
fnp-3806	4442	1	acta	acta	PROPN
fnp-3806	4442	2	neuropathol	neuropathol	PROPN
fnp-3806	4442	3	2015	2015	NUM
fnp-3806	4442	4	;	;	PUNCT
fnp-3806	4442	5	129	129	NUM
fnp-3806	4442	6	:	:	PUNCT
fnp-3806	4442	7	757	757	PROPN
fnp-3806	4442	8	-	-	SYM
fnp-3806	4442	9	762	762	NUM
fnp-3806	4442	10	.	.	PUNCT
fnp-3806	4443	1	https://doi.org/10.1007/s00401-015-1407-2	https://doi.org/10.1007/s00401-015-1407-2	NUM
fnp-3806	4443	2	bell	bell	PROPN
fnp-3806	4443	3	wr	wr	PROPN
fnp-3806	4443	4	,	,	PUNCT
fnp-3806	4443	5	an	an	DET
fnp-3806	4443	6	y	y	PROPN
fnp-3806	4443	7	,	,	PUNCT
fnp-3806	4443	8	kageyama	kageyama	PROPN
fnp-3806	4443	9	y	y	PROPN
fnp-3806	4443	10	,	,	PUNCT
fnp-3806	4444	1	et	et	PROPN
fnp-3806	4444	2	al	al	PROPN
fnp-3806	4444	3	.	.	PROPN
fnp-3806	4444	4	neuropathologic	neuropathologic	PROPN
fnp-3806	4444	5	,	,	PUNCT
fnp-3806	4444	6	genetic	genetic	ADJ
fnp-3806	4444	7	,	,	PUNCT
fnp-3806	4444	8	and	and	CCONJ
fnp-3806	4444	9	longitudinal	longitudinal	ADJ
fnp-3806	4444	10	cognitive	cognitive	ADJ
fnp-3806	4444	11	profiles	profile	NOUN
fnp-3806	4444	12	in	in	ADP
fnp-3806	4444	13	primary	primary	ADJ
fnp-3806	4444	14	age	age	NOUN
fnp-3806	4444	15	-	-	PUNCT
fnp-3806	4444	16	related	relate	VERB
fnp-3806	4444	17	tauopathy	tauopathy	NOUN
fnp-3806	4444	18	(	(	PUNCT
fnp-3806	4444	19	part	part	NOUN
fnp-3806	4444	20	)	)	PUNCT
fnp-3806	4444	21	and	and	CCONJ
fnp-3806	4444	22	alzheimer	alzheimer	PROPN
fnp-3806	4444	23	’s	’s	PART
fnp-3806	4444	24	disease	disease	NOUN
fnp-3806	4444	25	.	.	PUNCT
fnp-3806	4445	1	alzheimers	alzheimers	PROPN
fnp-3806	4445	2	dement	dement	PROPN
fnp-3806	4445	3	2019	2019	NUM
fnp-3806	4445	4	;	;	PUNCT
fnp-3806	4445	5	15:8	15:8	NUM
fnp-3806	4445	6	-	-	SYM
fnp-3806	4445	7	16	16	NUM
fnp-3806	4445	8	.	.	PUNCT
fnp-3806	4446	1	https://doi.org/10.1016/j.jalz.2018.07.215	https://doi.org/10.1016/j.jalz.2018.07.215	VERB
fnp-3806	4446	2	teylan	teylan	NOUN
fnp-3806	4446	3	m	m	NOUN
fnp-3806	4446	4	,	,	PUNCT
fnp-3806	4446	5	mock	mock	ADJ
fnp-3806	4446	6	c	c	NOUN
fnp-3806	4446	7	,	,	PUNCT
fnp-3806	4446	8	gauthreaux	gauthreaux	ADJ
fnp-3806	4446	9	k	k	NOUN
fnp-3806	4446	10	,	,	PUNCT
fnp-3806	4446	11	et	et	PROPN
fnp-3806	4446	12	al	al	PROPN
fnp-3806	4446	13	.	.	PROPN
fnp-3806	4446	14	cognitive	cognitive	ADJ
fnp-3806	4446	15	trajectory	trajectory	NOUN
fnp-3806	4446	16	in	in	ADP
fnp-3806	4446	17	mild	mild	ADJ
fnp-3806	4446	18	cognitive	cognitive	ADJ
fnp-3806	4446	19	impairment	impairment	NOUN
fnp-3806	4446	20	due	due	ADP
fnp-3806	4446	21	to	to	ADP
fnp-3806	4446	22	primary	primary	ADJ
fnp-3806	4446	23	age	age	NOUN
fnp-3806	4446	24	-	-	PUNCT
fnp-3806	4446	25	related	relate	VERB
fnp-3806	4446	26	tauopathy	tauopathy	NOUN
fnp-3806	4446	27	.	.	PUNCT
fnp-3806	4447	1	brain	brain	NOUN
fnp-3806	4447	2	2020	2020	NUM
fnp-3806	4447	3	;	;	PUNCT
fnp-3806	4447	4	143	143	NUM
fnp-3806	4447	5	;	;	PUNCT
fnp-3806	4447	6	611	611	NUM
fnp-3806	4447	7	-	-	SYM
fnp-3806	4447	8	621	621	NUM
fnp-3806	4447	9	.	.	PUNCT
fnp-3806	4448	1	https://doi.org/10.1093/brain/awz403	https://doi.org/10.1093/brain/awz403	NOUN
fnp-3806	4448	2	braak	braak	VERB
fnp-3806	4448	3	h	h	PROPN
fnp-3806	4448	4	,	,	PUNCT
fnp-3806	4448	5	thal	thal	PROPN
fnp-3806	4448	6	dr	dr	PROPN
fnp-3806	4448	7	,	,	PUNCT
fnp-3806	4448	8	ghebremedhin	ghebremedhin	NOUN
fnp-3806	4448	9	e	e	NOUN
fnp-3806	4448	10	,	,	PUNCT
fnp-3806	4448	11	et	et	PROPN
fnp-3806	4448	12	al	al	PROPN
fnp-3806	4448	13	.	.	PUNCT
fnp-3806	4449	1	stages	stage	NOUN
fnp-3806	4449	2	of	of	ADP
fnp-3806	4449	3	the	the	DET
fnp-3806	4449	4	pathologic	pathologic	ADJ
fnp-3806	4449	5	process	process	NOUN
fnp-3806	4449	6	in	in	ADP
fnp-3806	4449	7	alzheimer	alzheimer	PROPN
fnp-3806	4449	8	disease	disease	NOUN
fnp-3806	4449	9	:	:	PUNCT
fnp-3806	4449	10	age	age	NOUN
fnp-3806	4449	11	categories	category	NOUN
fnp-3806	4449	12	from	from	ADP
fnp-3806	4449	13	1	1	NUM
fnp-3806	4449	14	to	to	PART
fnp-3806	4449	15	100	100	NUM
fnp-3806	4449	16	years	year	NOUN
fnp-3806	4449	17	.	.	PUNCT
fnp-3806	4450	1	j	j	PROPN
fnp-3806	4450	2	neuropathol	neuropathol	PROPN
fnp-3806	4450	3	exp	exp	PROPN
fnp-3806	4450	4	neurol	neurol	PROPN
fnp-3806	4450	5	2011	2011	NUM
fnp-3806	4450	6	;	;	PUNCT
fnp-3806	4450	7	70	70	NUM
fnp-3806	4450	8	:	:	PUNCT
fnp-3806	4450	9	960	960	NUM
fnp-3806	4450	10	-	-	SYM
fnp-3806	4450	11	969	969	NUM
fnp-3806	4450	12	.	.	PUNCT
fnp-3806	4451	1	https://doi.org/10.1097/nen.0b013e318232a379	https://doi.org/10.1097/nen.0b013e318232a379	PROPN
fnp-3806	4451	2	jellinger	jellinger	PROPN
fnp-3806	4451	3	ka	ka	PROPN
fnp-3806	4451	4	,	,	PUNCT
fnp-3806	4451	5	bancher	bancher	ADJ
fnp-3806	4451	6	c.	c.	PROPN
fnp-3806	4451	7	senile	senile	ADJ
fnp-3806	4451	8	dementia	dementia	NOUN
fnp-3806	4451	9	with	with	ADP
fnp-3806	4451	10	tangles	tangle	NOUN
fnp-3806	4451	11	(	(	PUNCT
fnp-3806	4451	12	tangle	tangle	VERB
fnp-3806	4451	13	predominant	predominant	ADJ
fnp-3806	4451	14	form	form	NOUN
fnp-3806	4451	15	of	of	ADP
fnp-3806	4451	16	senile	senile	ADJ
fnp-3806	4451	17	dementia	dementia	NOUN
fnp-3806	4451	18	)	)	PUNCT
fnp-3806	4451	19	.	.	PUNCT
fnp-3806	4452	1	brain	brain	NOUN
fnp-3806	4452	2	pathol	pathol	NOUN
fnp-3806	4452	3	1998	1998	NUM
fnp-3806	4452	4	;	;	PUNCT
fnp-3806	4452	5	8	8	NUM
fnp-3806	4452	6	:	:	SYM
fnp-3806	4452	7	367	367	NUM
fnp-3806	4452	8	-	-	SYM
fnp-3806	4452	9	376	376	NUM
fnp-3806	4452	10	.	.	PUNCT
fnp-3806	4453	1	https://doi.org/10.1111/j.1750-3639.1998.tb00160.x	https://doi.org/10.1111/j.1750-3639.1998.tb00160.x	PROPN
fnp-3806	4453	2	jellinger	jellinger	PROPN
fnp-3806	4453	3	ka	ka	PROPN
fnp-3806	4453	4	,	,	PUNCT
fnp-3806	4453	5	attems	attem	VERB
fnp-3806	4453	6	j.	j.	PROPN
fnp-3806	4453	7	prevalence	prevalence	PROPN
fnp-3806	4453	8	of	of	ADP
fnp-3806	4453	9	dementia	dementia	NOUN
fnp-3806	4453	10	disorders	disorder	NOUN
fnp-3806	4453	11	in	in	ADP
fnp-3806	4453	12	the	the	DET
fnp-3806	4453	13	oldest	oldest	ADV
fnp-3806	4453	14	-	-	PUNCT
fnp-3806	4453	15	old	old	ADJ
fnp-3806	4453	16	:	:	PUNCT
fnp-3806	4453	17	an	an	DET
fnp-3806	4453	18	autopsy	autopsy	ADJ
fnp-3806	4453	19	study	study	NOUN
fnp-3806	4453	20	.	.	PUNCT
fnp-3806	4454	1	acta	acta	PROPN
fnp-3806	4454	2	neuropathol	neuropathol	PROPN
fnp-3806	4454	3	2010	2010	NUM
fnp-3806	4454	4	:	:	PUNCT
fnp-3806	4455	1	119:421	119:421	NUM
fnp-3806	4455	2	-	-	SYM
fnp-3806	4455	3	433	433	NUM
fnp-3806	4455	4	.	.	PUNCT
fnp-3806	4456	1	https://doi.org/10.1007/s00401-010-0654-5	https://doi.org/10.1007/s00401-010-0654-5	PROPN
fnp-3806	4456	2	jellinger	jellinger	PROPN
fnp-3806	4456	3	ka	ka	PROPN
fnp-3806	4456	4	.	.	PUNCT
fnp-3806	4457	1	different	different	ADJ
fnp-3806	4457	2	patterns	pattern	NOUN
fnp-3806	4457	3	of	of	ADP
fnp-3806	4457	4	hippocampal	hippocampal	ADJ
fnp-3806	4457	5	tau	tau	PROPN
fnp-3806	4457	6	pathology	pathology	PROPN
fnp-3806	4457	7	in	in	ADP
fnp-3806	4457	8	alzheimer	alzheimer	PROPN
fnp-3806	4457	9	's	's	PART
fnp-3806	4457	10	disease	disease	NOUN
fnp-3806	4457	11	and	and	CCONJ
fnp-3806	4457	12	part	part	NOUN
fnp-3806	4457	13	.	.	PUNCT
fnp-3806	4458	1	acta	acta	PROPN
fnp-3806	4458	2	neuropathol	neuropathol	PROPN
fnp-3806	4458	3	2018	2018	NUM
fnp-3806	4458	4	;	;	PUNCT
fnp-3806	4458	5	136:811	136:811	NUM
fnp-3806	4458	6	-	-	PUNCT
fnp-3806	4458	7	813	813	NUM
fnp-3806	4458	8	.	.	PUNCT
fnp-3806	4459	1	https://doi.org/10.1007/s00401-018-1894-z	https://doi.org/10.1007/s00401-018-1894-z	PROPN
fnp-3806	4459	2	zhang	zhang	PROPN
fnp-3806	4459	3	l	l	PROPN
fnp-3806	4459	4	,	,	PUNCT
fnp-3806	4459	5	jiang	jiang	PROPN
fnp-3806	4459	6	y	y	PROPN
fnp-3806	4459	7	,	,	PUNCT
fnp-3806	4459	8	zhu	zhu	PROPN
fnp-3806	4459	9	j	j	PROPN
fnp-3806	4459	10	,	,	PUNCT
fnp-3806	4459	11	et	et	PROPN
fnp-3806	4459	12	al	al	PROPN
fnp-3806	4459	13	.	.	PROPN
fnp-3806	4460	1	quantitative	quantitative	ADJ
fnp-3806	4460	2	assessment	assessment	NOUN
fnp-3806	4460	3	of	of	ADP
fnp-3806	4460	4	hippocampal	hippocampal	ADJ
fnp-3806	4460	5	tau	tau	PROPN
fnp-3806	4460	6	pathology	pathology	NOUN
fnp-3806	4460	7	in	in	ADP
fnp-3806	4460	8	ad	ad	NOUN
fnp-3806	4460	9	and	and	CCONJ
fnp-3806	4460	10	part	part	NOUN
fnp-3806	4460	11	.	.	PUNCT
fnp-3806	4461	1	j	j	PROPN
fnp-3806	4461	2	mol	mol	ADP
fnp-3806	4461	3	neurosci	neurosci	PROPN
fnp-3806	4461	4	2020;70:1808	2020;70:1808	NUM
fnp-3806	4461	5	-	-	SYM
fnp-3806	4461	6	1811	1811	NUM
fnp-3806	4461	7	.	.	PUNCT
fnp-3806	4462	1	https://doi.org/10.1007/s12031-020-01573-0	https://doi.org/10.1007/s12031-020-01573-0	PROPN
fnp-3806	4463	1	duyckaerts	duyckaert	NOUN
fnp-3806	4463	2	c	c	PROPN
fnp-3806	4463	3	,	,	PUNCT
fnp-3806	4463	4	braak	braak	PROPN
fnp-3806	4463	5	h	h	PROPN
fnp-3806	4463	6	,	,	PUNCT
fnp-3806	4463	7	brion	brion	PROPN
fnp-3806	4463	8	jp	jp	PROPN
fnp-3806	4463	9	,	,	PUNCT
fnp-3806	4464	1	et	et	PROPN
fnp-3806	4464	2	al	al	PROPN
fnp-3806	4464	3	.	.	PROPN
fnp-3806	4464	4	part	part	NOUN
fnp-3806	4464	5	is	be	AUX
fnp-3806	4464	6	part	part	NOUN
fnp-3806	4464	7	of	of	ADP
fnp-3806	4464	8	alzheimer	alzheimer	PROPN
fnp-3806	4464	9	disease	disease	PROPN
fnp-3806	4464	10	.	.	PUNCT
fnp-3806	4465	1	acta	acta	PROPN
fnp-3806	4465	2	neuropathol	neuropathol	PROPN
fnp-3806	4465	3	2015	2015	NUM
fnp-3806	4465	4	;	;	PUNCT
fnp-3806	4465	5	129:749	129:749	NUM
fnp-3806	4465	6	-	-	PUNCT
fnp-3806	4465	7	756	756	NUM
fnp-3806	4465	8	.	.	PUNCT
fnp-3806	4466	1	https://doi.org/10.1007/s00401-015-1390-7	https://doi.org/10.1007/s00401-015-1390-7	NUM
fnp-3806	4466	2	mcmillan	mcmillan	PROPN
fnp-3806	4466	3	ct	ct	PROPN
fnp-3806	4466	4	,	,	PUNCT
fnp-3806	4466	5	lee	lee	PROPN
fnp-3806	4466	6	eb	eb	PROPN
fnp-3806	4466	7	,	,	PUNCT
fnp-3806	4466	8	jefferson	jefferson	PROPN
fnp-3806	4466	9	-	-	PUNCT
fnp-3806	4466	10	george	george	PROPN
fnp-3806	4466	11	k	k	PROPN
fnp-3806	4466	12	,	,	PUNCT
fnp-3806	4467	1	et	et	PROPN
fnp-3806	4467	2	al	al	PROPN
fnp-3806	4467	3	.	.	PROPN
fnp-3806	4467	4	alzheimer	alzheimer	PROPN
fnp-3806	4467	5	’s	’s	PART
fnp-3806	4467	6	genetic	genetic	ADJ
fnp-3806	4467	7	risk	risk	NOUN
fnp-3806	4467	8	is	be	AUX
fnp-3806	4467	9	reduced	reduce	VERB
fnp-3806	4467	10	in	in	ADP
fnp-3806	4467	11	primary	primary	ADJ
fnp-3806	4467	12	age	age	NOUN
fnp-3806	4467	13	-	-	PUNCT
fnp-3806	4467	14	related	relate	VERB
fnp-3806	4467	15	tauopathy	tauopathy	NOUN
fnp-3806	4467	16	:	:	PUNCT
fnp-3806	4467	17	a	a	DET
fnp-3806	4467	18	potential	potential	ADJ
fnp-3806	4467	19	model	model	NOUN
fnp-3806	4467	20	of	of	ADP
fnp-3806	4467	21	resistance	resistance	NOUN
fnp-3806	4467	22	?	?	PUNCT
fnp-3806	4468	1	annals	annal	NOUN
fnp-3806	4468	2	of	of	ADP
fnp-3806	4468	3	clin	clin	PROPN
fnp-3806	4468	4	transl	transl	PROPN
fnp-3806	4468	5	neurol	neurol	PROPN
fnp-3806	4468	6	2018	2018	NUM
fnp-3806	4468	7	;	;	PUNCT
fnp-3806	4468	8	5	5	NUM
fnp-3806	4468	9	:	:	PUNCT
fnp-3806	4468	10	927	927	NUM
fnp-3806	4468	11	-	-	SYM
fnp-3806	4468	12	934	934	NUM
fnp-3806	4468	13	.	.	PUNCT
fnp-3806	4469	1	https://doi.org/10.1002/acn3.581	https://doi.org/10.1002/acn3.581	PROPN
fnp-3806	4469	2	santa	santa	PROPN
fnp-3806	4469	3	-	-	PUNCT
fnp-3806	4469	4	maria	maria	PROPN
fnp-3806	4470	1	i	i	PROPN
fnp-3806	4470	2	,	,	PUNCT
fnp-3806	4470	3	haggiagi	haggiagi	VERB
fnp-3806	4470	4	a	a	PRON
fnp-3806	4470	5	,	,	PUNCT
fnp-3806	4470	6	liu	liu	PROPN
fnp-3806	4470	7	x	x	PROPN
fnp-3806	4470	8	,	,	PUNCT
fnp-3806	4470	9	et	et	PROPN
fnp-3806	4470	10	al	al	PROPN
fnp-3806	4470	11	.	.	PUNCT
fnp-3806	4471	1	the	the	DET
fnp-3806	4471	2	mapt	mapt	NOUN
fnp-3806	4471	3	h1	h1	NOUN
fnp-3806	4471	4	haplotype	haplotype	NOUN
fnp-3806	4471	5	is	be	AUX
fnp-3806	4471	6	associated	associate	VERB
fnp-3806	4471	7	with	with	ADP
fnp-3806	4471	8	tangle	tangle	NOUN
fnp-3806	4471	9	-	-	PUNCT
fnp-3806	4471	10	predominant	predominant	ADJ
fnp-3806	4471	11	dementia	dementia	NOUN
fnp-3806	4471	12	.	.	PUNCT
fnp-3806	4472	1	acta	acta	PROPN
fnp-3806	4472	2	neuropathol	neuropathol	PROPN
fnp-3806	4472	3	2012;124:693–704	2012;124:693–704	PROPN
fnp-3806	4472	4	.	.	PUNCT
fnp-3806	4473	1	https://doi.org/10.1007/s00401-012-1017-1	https://doi.org/10.1007/s00401-012-1017-1	NOUN
fnp-3806	4474	1	schmidt	schmidt	PROPN
fnp-3806	4474	2	c	c	PROPN
fnp-3806	4474	3	,	,	PUNCT
fnp-3806	4474	4	wolff	wolff	PROPN
fnp-3806	4474	5	m	m	PROPN
fnp-3806	4474	6	,	,	PUNCT
fnp-3806	4474	7	weitz	weitz	PROPN
fnp-3806	4474	8	m	m	PROPN
fnp-3806	4474	9	,	,	PUNCT
fnp-3806	4474	10	et	et	PROPN
fnp-3806	4474	11	al	al	PROPN
fnp-3806	4474	12	.	.	PUNCT
fnp-3806	4474	13	rapidly	rapidly	ADV
fnp-3806	4474	14	progressive	progressive	ADJ
fnp-3806	4474	15	alzheimer	alzheimer	PROPN
fnp-3806	4474	16	disease	disease	PROPN
fnp-3806	4474	17	.	.	PUNCT
fnp-3806	4475	1	arch	arch	ADJ
fnp-3806	4475	2	neurol	neurol	NOUN
fnp-3806	4475	3	2011	2011	NUM
fnp-3806	4475	4	;	;	PUNCT
fnp-3806	4475	5	68:1124	68:1124	NUM
fnp-3806	4475	6	-	-	X
fnp-3806	4475	7	1130	1130	NUM
fnp-3806	4475	8	.	.	PUNCT
fnp-3806	4476	1	https://doi.org/10.1001/archneurol.2011.189	https://doi.org/10.1001/archneurol.2011.189	PROPN
fnp-3806	4476	2	stoeck	stoeck	PROPN
fnp-3806	4476	3	k	k	PROPN
fnp-3806	4476	4	,	,	PUNCT
fnp-3806	4476	5	schmitz	schmitz	PROPN
fnp-3806	4476	6	m	m	PROPN
fnp-3806	4476	7	,	,	PUNCT
fnp-3806	4476	8	ebert	ebert	PROPN
fnp-3806	4476	9	e	e	PROPN
fnp-3806	4476	10	,	,	PUNCT
fnp-3806	4476	11	et	et	PROPN
fnp-3806	4476	12	al	al	PROPN
fnp-3806	4476	13	.	.	PROPN
fnp-3806	4476	14	immune	immune	ADJ
fnp-3806	4476	15	responses	response	NOUN
fnp-3806	4476	16	in	in	ADP
fnp-3806	4476	17	rapidly	rapidly	ADV
fnp-3806	4476	18	progressive	progressive	ADJ
fnp-3806	4476	19	dementia	dementia	NOUN
fnp-3806	4476	20	:	:	PUNCT
fnp-3806	4476	21	a	a	DET
fnp-3806	4476	22	comparative	comparative	ADJ
fnp-3806	4476	23	study	study	NOUN
fnp-3806	4476	24	of	of	ADP
fnp-3806	4476	25	neuroinflammatory	neuroinflammatory	ADJ
fnp-3806	4476	26	markers	marker	NOUN
fnp-3806	4476	27	in	in	ADP
fnp-3806	4476	28	creutzfeldt	creutzfeldt	ADJ
fnp-3806	4476	29	-	-	PUNCT
fnp-3806	4476	30	jakob	jakob	ADJ
fnp-3806	4476	31	disease	disease	PROPN
fnp-3806	4476	32	,	,	PUNCT
fnp-3806	4476	33	alzheimer	alzheimer	PROPN
fnp-3806	4476	34	’s	’s	PART
fnp-3806	4476	35	disease	disease	NOUN
fnp-3806	4476	36	and	and	CCONJ
fnp-3806	4476	37	multiple	multiple	ADJ
fnp-3806	4476	38	sclerosis	sclerosis	NOUN
fnp-3806	4476	39	.	.	PUNCT
fnp-3806	4477	1	j	j	PROPN
fnp-3806	4477	2	neuroinflammation	neuroinflammation	NOUN
fnp-3806	4477	3	2014;11:170	2014;11:170	ADV
fnp-3806	4477	4	.	.	PUNCT
fnp-3806	4478	1	https://doi.org/10.1186/s12974-014-0170-y	https://doi.org/10.1186/s12974-014-0170-y	NOUN
fnp-3806	4478	2	schmidt	schmidt	PROPN
fnp-3806	4478	3	c	c	PROPN
fnp-3806	4478	4	,	,	PUNCT
fnp-3806	4478	5	haik	haik	PROPN
fnp-3806	4478	6	s	s	PROPN
fnp-3806	4478	7	,	,	PUNCT
fnp-3806	4478	8	satoh	satoh	NOUN
fnp-3806	4478	9	k	k	PROPN
fnp-3806	4478	10	,	,	PUNCT
fnp-3806	4478	11	et	et	PROPN
fnp-3806	4478	12	al	al	PROPN
fnp-3806	4478	13	.	.	PUNCT
fnp-3806	4478	14	rapidly	rapidly	ADV
fnp-3806	4478	15	progressive	progressive	ADJ
fnp-3806	4478	16	alzheimer	alzheimer	PROPN
fnp-3806	4478	17	’s	’s	PART
fnp-3806	4478	18	disease	disease	NOUN
fnp-3806	4478	19	:	:	PUNCT
fnp-3806	4478	20	a	a	DET
fnp-3806	4478	21	multicenter	multicenter	ADJ
fnp-3806	4478	22	update	update	NOUN
fnp-3806	4478	23	.	.	PUNCT
fnp-3806	4479	1	j	j	PROPN
fnp-3806	4479	2	alzheimer	alzheimer	PROPN
fnp-3806	4479	3	’s	’s	PART
fnp-3806	4479	4	dis	dis	PROPN
fnp-3806	4479	5	2012;30:751	2012;30:751	PROPN
fnp-3806	4479	6	-	-	PUNCT
fnp-3806	4479	7	756	756	NUM
fnp-3806	4479	8	.	.	PUNCT
fnp-3806	4480	1	https://doi.org/10.3233/jad-2012-120007	https://doi.org/10.3233/jad-2012-120007	PROPN
fnp-3806	4480	2	cohen	cohen	PROPN
fnp-3806	4480	3	m	m	PROPN
fnp-3806	4480	4	,	,	PUNCT
fnp-3806	4480	5	appleby	appleby	PROPN
fnp-3806	4480	6	b	b	PROPN
fnp-3806	4480	7	,	,	PUNCT
fnp-3806	4480	8	safar	safar	PROPN
fnp-3806	4481	1	jg	jg	PROPN
fnp-3806	4481	2	.	.	PUNCT
fnp-3806	4482	1	distinct	distinct	ADJ
fnp-3806	4482	2	prion	prion	NOUN
fnp-3806	4482	3	-	-	PUNCT
fnp-3806	4482	4	like	like	ADJ
fnp-3806	4482	5	strains	strain	NOUN
fnp-3806	4482	6	of	of	ADP
fnp-3806	4482	7	amyloid	amyloid	NOUN
fnp-3806	4482	8	beta	beta	NOUN
fnp-3806	4482	9	implicated	implicate	VERB
fnp-3806	4482	10	in	in	ADP
fnp-3806	4482	11	phenotypic	phenotypic	ADJ
fnp-3806	4482	12	diversity	diversity	NOUN
fnp-3806	4482	13	of	of	ADP
fnp-3806	4482	14	alzheimer	alzheimer	PROPN
fnp-3806	4482	15	’s	’s	PART
fnp-3806	4482	16	disease	disease	NOUN
fnp-3806	4482	17	.	.	PUNCT
fnp-3806	4483	1	prion	prion	NOUN
fnp-3806	4483	2	2016;10:9	2016;10:9	NUM
fnp-3806	4483	3	-	-	SYM
fnp-3806	4483	4	17	17	NUM
fnp-3806	4483	5	.	.	PUNCT
fnp-3806	4484	1	https://doi.org/10.1080/19336896.2015.1123371	https://doi.org/10.1080/19336896.2015.1123371	PROPN
fnp-3806	4484	2	drummond	drummond	PROPN
fnp-3806	4484	3	e	e	PROPN
fnp-3806	4484	4	,	,	PUNCT
fnp-3806	4484	5	nayak	nayak	PROPN
fnp-3806	4484	6	s	s	PART
fnp-3806	4484	7	,	,	PUNCT
fnp-3806	4484	8	faustin	faustin	VERB
fnp-3806	4484	9	a	a	PRON
fnp-3806	4484	10	,	,	PUNCT
fnp-3806	4484	11	et	et	PROPN
fnp-3806	4484	12	al	al	PROPN
fnp-3806	4484	13	.	.	PUNCT
fnp-3806	4485	1	proteomic	proteomic	ADJ
fnp-3806	4485	2	differences	difference	NOUN
fnp-3806	4485	3	in	in	ADP
fnp-3806	4485	4	amyloid	amyloid	NOUN
fnp-3806	4485	5	plaques	plaque	NOUN
fnp-3806	4485	6	in	in	ADP
fnp-3806	4485	7	rapidly	rapidly	ADV
fnp-3806	4485	8	progressive	progressive	ADJ
fnp-3806	4485	9	and	and	CCONJ
fnp-3806	4485	10	sporadic	sporadic	ADJ
fnp-3806	4485	11	alzheimer	alzheimer	PROPN
fnp-3806	4485	12	's	's	PART
fnp-3806	4485	13	disease	disease	NOUN
fnp-3806	4485	14	.	.	PUNCT
fnp-3806	4486	1	acta	acta	PROPN
fnp-3806	4486	2	neuropathol	neuropathol	PROPN
fnp-3806	4486	3	2017;133:933	2017;133:933	NUM
fnp-3806	4486	4	-	-	SYM
fnp-3806	4486	5	954	954	NUM
fnp-3806	4486	6	.	.	PUNCT
fnp-3806	4487	1	https://doi.org/10.1007/s00401-017-1691-0	https://doi.org/10.1007/s00401-017-1691-0	NUM
fnp-3806	4487	2	zafar	zafar	PROPN
fnp-3806	4487	3	s	s	PROPN
fnp-3806	4487	4	,	,	PUNCT
fnp-3806	4487	5	shafiq	shafiq	PROPN
fnp-3806	4487	6	m	m	PROPN
fnp-3806	4487	7	,	,	PUNCT
fnp-3806	4487	8	younas	younas	PROPN
fnp-3806	4487	9	n	n	CCONJ
fnp-3806	4487	10	,	,	PUNCT
fnp-3806	4487	11	et	et	PROPN
fnp-3806	4487	12	al	al	PROPN
fnp-3806	4487	13	.	.	PROPN
fnp-3806	4487	14	prion	prion	NOUN
fnp-3806	4487	15	protein	protein	NOUN
fnp-3806	4487	16	interactome	interactome	NOUN
fnp-3806	4487	17	:	:	PUNCT
fnp-3806	4487	18	identifying	identify	VERB
fnp-3806	4487	19	novel	novel	ADJ
fnp-3806	4487	20	targets	target	NOUN
fnp-3806	4487	21	in	in	ADP
fnp-3806	4487	22	slowly	slowly	ADV
fnp-3806	4487	23	and	and	CCONJ
fnp-3806	4487	24	rapidly	rapidly	ADV
fnp-3806	4487	25	progressive	progressive	ADJ
fnp-3806	4487	26	forms	form	NOUN
fnp-3806	4487	27	of	of	ADP
fnp-3806	4487	28	alzheimer	alzheimer	PROPN
fnp-3806	4487	29	's	's	PART
fnp-3806	4487	30	disease	disease	NOUN
fnp-3806	4487	31	.	.	PUNCT
fnp-3806	4488	1	j	j	PROPN
fnp-3806	4488	2	alzheimers	alzheimers	PROPN
fnp-3806	4488	3	dis	dis	PROPN
fnp-3806	4488	4	2017;59:265	2017;59:265	NOUN
fnp-3806	4488	5	-	-	SYM
fnp-3806	4488	6	275	275	NUM
fnp-3806	4488	7	.	.	PUNCT
fnp-3806	4489	1	https://doi.org/10.3233/jad-170237	https://doi.org/10.3233/jad-170237	PROPN
fnp-3806	4489	2	shafiq	shafiq	PROPN
fnp-3806	4489	3	m	m	PROPN
fnp-3806	4489	4	,	,	PUNCT
fnp-3806	4489	5	zafar	zafar	PROPN
fnp-3806	4489	6	s	s	PART
fnp-3806	4489	7	,	,	PUNCT
fnp-3806	4489	8	younas	younas	NOUN
fnp-3806	4489	9	n	n	CCONJ
fnp-3806	4489	10	,	,	PUNCT
fnp-3806	4489	11	et	et	PROPN
fnp-3806	4489	12	al	al	PROPN
fnp-3806	4489	13	.	.	PROPN
fnp-3806	4490	1	prion	prion	NOUN
fnp-3806	4490	2	protein	protein	NOUN
fnp-3806	4490	3	oligomers	oligomer	NOUN
fnp-3806	4490	4	cause	cause	VERB
fnp-3806	4490	5	neuronal	neuronal	ADJ
fnp-3806	4490	6	cytoskeletal	cytoskeletal	ADJ
fnp-3806	4490	7	damage	damage	NOUN
fnp-3806	4490	8	in	in	ADP
fnp-3806	4490	9	rapidly	rapidly	ADV
fnp-3806	4490	10	progressive	progressive	ADJ
fnp-3806	4490	11	alzheimer	alzheimer	PROPN
fnp-3806	4490	12	's	's	PART
fnp-3806	4490	13	disease	disease	NOUN
fnp-3806	4490	14	.	.	PUNCT
fnp-3806	4491	1	mol	mol	ADP
fnp-3806	4491	2	neurodegener	neurodegener	PROPN
fnp-3806	4491	3	2021;16:11	2021;16:11	NUM
fnp-3806	4491	4	.	.	PUNCT
fnp-3806	4492	1	https://doi.org/10.1186/s13024-021-00422-x	https://doi.org/10.1186/s13024-021-00422-x	PROPN
fnp-3806	4492	2	noor	noor	PROPN
fnp-3806	4492	3	a	a	PROPN
fnp-3806	4492	4	,	,	PUNCT
fnp-3806	4492	5	zafar	zafar	PROPN
fnp-3806	4492	6	s	s	PART
fnp-3806	4492	7	,	,	PUNCT
fnp-3806	4492	8	shafiq	shafiq	PROPN
fnp-3806	4492	9	m	m	PROPN
fnp-3806	4492	10	,	,	PUNCT
fnp-3806	4492	11	et	et	PROPN
fnp-3806	4492	12	al	al	PROPN
fnp-3806	4492	13	.	.	PUNCT
fnp-3806	4493	1	molecular	molecular	ADJ
fnp-3806	4493	2	profiles	profile	NOUN
fnp-3806	4493	3	of	of	ADP
fnp-3806	4493	4	amyloid‑β	amyloid‑β	PROPN
fnp-3806	4493	5	proteoforms	proteoform	NOUN
fnp-3806	4493	6	in	in	ADP
fnp-3806	4493	7	typical	typical	ADJ
fnp-3806	4493	8	and	and	CCONJ
fnp-3806	4493	9	rapidly	rapidly	ADV
fnp-3806	4493	10	progressive	progressive	ADJ
fnp-3806	4493	11	alzheimer	alzheimer	PROPN
fnp-3806	4493	12	’s	’s	PART
fnp-3806	4493	13	disease	disease	NOUN
fnp-3806	4493	14	.	.	PUNCT
fnp-3806	4494	1	mol	mol	ADP
fnp-3806	4494	2	neurobiol	neurobiol	PROPN
fnp-3806	4494	3	2022	2022	NUM
fnp-3806	4494	4	59:17	59:17	NUM
fnp-3806	4494	5	-	-	SYM
fnp-3806	4494	6	34	34	NUM
fnp-3806	4494	7	.	.	PUNCT
fnp-3806	4495	1	https://doi.org/10.1007/s12035-021-02566-9	https://doi.org/10.1007/s12035-021-02566-9	NOUN
fnp-3806	4495	2	younas	youna	NOUN
fnp-3806	4495	3	n	n	CCONJ
fnp-3806	4495	4	,	,	PUNCT
fnp-3806	4495	5	zafar	zafar	PROPN
fnp-3806	4495	6	s	s	PROPN
fnp-3806	4495	7	,	,	PUNCT
fnp-3806	4495	8	shafiq	shafiq	PROPN
fnp-3806	4495	9	m	m	PROPN
fnp-3806	4495	10	,	,	PUNCT
fnp-3806	4495	11	et	et	PROPN
fnp-3806	4495	12	al	al	PROPN
fnp-3806	4495	13	.	.	PROPN
fnp-3806	4495	14	sfpq	sfpq	PROPN
fnp-3806	4495	15	and	and	CCONJ
fnp-3806	4495	16	tau	tau	NOUN
fnp-3806	4495	17	:	:	PUNCT
fnp-3806	4495	18	critical	critical	ADJ
fnp-3806	4495	19	factors	factor	NOUN
fnp-3806	4495	20	contributing	contribute	VERB
fnp-3806	4495	21	to	to	ADP
fnp-3806	4495	22	rapid	rapid	ADJ
fnp-3806	4495	23	progression	progression	NOUN
fnp-3806	4495	24	of	of	ADP
fnp-3806	4495	25	alzheimer	alzheimer	PROPN
fnp-3806	4495	26	’s	’s	PART
fnp-3806	4495	27	disease	disease	NOUN
fnp-3806	4495	28	.	.	PUNCT
fnp-3806	4496	1	acta	acta	PROPN
fnp-3806	4496	2	neuropathol	neuropathol	PROPN
fnp-3806	4496	3	2020;140:317	2020;140:317	NUM
fnp-3806	4496	4	-	-	SYM
fnp-3806	4496	5	339	339	NUM
fnp-3806	4496	6	.	.	PUNCT
fnp-3806	4497	1	https://doi.org/10.1007/s00401-020-02178-y	https://doi.org/10.1007/s00401-020-02178-y	PROPN
fnp-3806	4497	2	arenaza	arenaza	PROPN
fnp-3806	4497	3	-	-	PUNCT
fnp-3806	4497	4	urquijo	urquijo	NOUN
fnp-3806	4497	5	em	em	PRON
fnp-3806	4497	6	,	,	PUNCT
fnp-3806	4497	7	vemuri	vemuri	PROPN
fnp-3806	4497	8	p.	p.	NOUN
fnp-3806	4497	9	resistance	resistance	NOUN
fnp-3806	4497	10	vs	vs	ADP
fnp-3806	4497	11	resilience	resilience	NOUN
fnp-3806	4497	12	to	to	ADP
fnp-3806	4497	13	alzheimer	alzheimer	PROPN
fnp-3806	4497	14	disease	disease	PROPN
fnp-3806	4497	15	:	:	PUNCT
fnp-3806	4497	16	clarifying	clarify	VERB
fnp-3806	4497	17	terminology	terminology	NOUN
fnp-3806	4497	18	for	for	ADP
fnp-3806	4497	19	preclinical	preclinical	ADJ
fnp-3806	4497	20	studies	study	NOUN
fnp-3806	4497	21	.	.	PUNCT
fnp-3806	4498	1	neurology	neurology	NOUN
fnp-3806	4498	2	2018;90:695	2018;90:695	PROPN
fnp-3806	4498	3	-	-	NUM
fnp-3806	4498	4	703	703	NUM
fnp-3806	4498	5	.	.	PUNCT
fnp-3806	4499	1	https://doi.org/10.1212/wnl.0000000000005303	https://doi.org/10.1212/wnl.0000000000005303	PROPN
fnp-3806	4499	2	andersen	andersen	PROPN
fnp-3806	4499	3	sl	sl	PROPN
fnp-3806	4499	4	.	.	PUNCT
fnp-3806	4499	5	centenarians	centenarian	NOUN
fnp-3806	4499	6	as	as	ADP
fnp-3806	4499	7	models	model	NOUN
fnp-3806	4499	8	of	of	ADP
fnp-3806	4499	9	resistance	resistance	NOUN
fnp-3806	4499	10	and	and	CCONJ
fnp-3806	4499	11	resilience	resilience	NOUN
fnp-3806	4499	12	to	to	ADP
fnp-3806	4499	13	alzheimer	alzheimer	PROPN
fnp-3806	4499	14	's	's	PART
fnp-3806	4499	15	disease	disease	NOUN
fnp-3806	4499	16	and	and	CCONJ
fnp-3806	4499	17	related	related	ADJ
fnp-3806	4499	18	dementias	dementia	NOUN
fnp-3806	4499	19	.	.	PUNCT
fnp-3806	4500	1	adv	adv	PROPN
fnp-3806	4500	2	geriatr	geriatr	PROPN
fnp-3806	4500	3	med	med	ADJ
fnp-3806	4500	4	res	re	NOUN
fnp-3806	4500	5	2020;2	2020;2	NUM
fnp-3806	4500	6	:	:	PUNCT
fnp-3806	4500	7	e200018	e200018	NOUN
fnp-3806	4500	8	.	.	PUNCT
fnp-3806	4501	1	https://doi.org/10.20900/agmr20200018	https://doi.org/10.20900/agmr20200018	NOUN
fnp-3806	4501	2	beker	beker	PROPN
fnp-3806	4501	3	n	n	PROPN
fnp-3806	4501	4	,	,	PUNCT
fnp-3806	4501	5	ganz	ganz	PROPN
fnp-3806	4501	6	a	a	PRON
fnp-3806	4501	7	,	,	PUNCT
fnp-3806	4501	8	hulsman	hulsman	PROPN
fnp-3806	4501	9	m	m	PROPN
fnp-3806	4501	10	,	,	PUNCT
fnp-3806	4501	11	et	et	PROPN
fnp-3806	4501	12	al	al	PROPN
fnp-3806	4501	13	.	.	PROPN
fnp-3806	4502	1	association	association	PROPN
fnp-3806	4502	2	of	of	ADP
fnp-3806	4502	3	cognitive	cognitive	ADJ
fnp-3806	4502	4	function	function	NOUN
fnp-3806	4502	5	trajectories	trajectory	NOUN
fnp-3806	4502	6	in	in	ADP
fnp-3806	4502	7	centenarians	centenarian	NOUN
fnp-3806	4502	8	with	with	ADP
fnp-3806	4502	9	postmortem	postmortem	PROPN
fnp-3806	4502	10	neuropathology	neuropathology	NOUN
fnp-3806	4502	11	,	,	PUNCT
fnp-3806	4502	12	physical	physical	ADJ
fnp-3806	4502	13	health	health	NOUN
fnp-3806	4502	14	,	,	PUNCT
fnp-3806	4502	15	and	and	CCONJ
fnp-3806	4502	16	other	other	ADJ
fnp-3806	4502	17	risk	risk	NOUN
fnp-3806	4502	18	factors	factor	NOUN
fnp-3806	4502	19	for	for	ADP
fnp-3806	4502	20	cognitive	cognitive	ADJ
fnp-3806	4502	21	decline	decline	NOUN
fnp-3806	4502	22	.	.	PUNCT
fnp-3806	4503	1	jama	jama	PROPN
fnp-3806	4503	2	2021;4	2021;4	PROPN
fnp-3806	4503	3	:	:	PUNCT
fnp-3806	4503	4	e2031654	e2031654	PROPN
fnp-3806	4503	5	.	.	PUNCT
fnp-3806	4504	1	https://doi.org/10.1001/jamanetworkopen.2020.31654	https://doi.org/10.1001/jamanetworkopen.2020.31654	PROPN
fnp-3806	4504	2	giannakopoulos	giannakopoulos	PROPN
fnp-3806	4504	3	p	p	NOUN
fnp-3806	4504	4	,	,	PUNCT
fnp-3806	4504	5	hof	hof	PROPN
fnp-3806	4504	6	pr	pr	NOUN
fnp-3806	4504	7	,	,	PUNCT
fnp-3806	4504	8	surini	surini	NOUN
fnp-3806	4504	9	m	m	PROPN
fnp-3806	4504	10	,	,	PUNCT
fnp-3806	4504	11	et	et	PROPN
fnp-3806	4504	12	al	al	PROPN
fnp-3806	4504	13	.	.	PROPN
fnp-3806	4505	1	quantittaive	quantittaive	ADJ
fnp-3806	4505	2	immunohistochemical	immunohistochemical	ADJ
fnp-3806	4505	3	analysis	analysis	NOUN
fnp-3806	4505	4	of	of	ADP
fnp-3806	4505	5	the	the	DET
fnp-3806	4505	6	distribution	distribution	NOUN
fnp-3806	4505	7	of	of	ADP
fnp-3806	4505	8	neurofibrillary	neurofibrillary	ADJ
fnp-3806	4505	9	tangles	tangle	NOUN
fnp-3806	4505	10	and	and	CCONJ
fnp-3806	4505	11	senile	senile	ADJ
fnp-3806	4505	12	plaques	plaque	NOUN
fnp-3806	4505	13	in	in	ADP
fnp-3806	4505	14	the	the	DET
fnp-3806	4505	15	cerebral	cerebral	ADJ
fnp-3806	4505	16	cortex	cortex	NOUN
fnp-3806	4505	17	of	of	ADP
fnp-3806	4505	18	nonagenarians	nonagenarian	NOUN
fnp-3806	4505	19	and	and	CCONJ
fnp-3806	4505	20	centenerians	centenerian	NOUN
fnp-3806	4505	21	.	.	PUNCT
fnp-3806	4506	1	acta	acta	PROPN
fnp-3806	4506	2	neuropathol	neuropathol	PROPN
fnp-3806	4506	3	1993;85:602	1993;85:602	PROPN
fnp-3806	4506	4	-	-	SYM
fnp-3806	4506	5	610	610	NUM
fnp-3806	4506	6	.	.	PUNCT
fnp-3806	4507	1	https://doi.org/10.1007/bf00334669	https://doi.org/10.1007/bf00334669	PART
fnp-3806	4507	2	giannakopoulos	giannakopoulos	PROPN
fnp-3806	4507	3	p	p	NOUN
fnp-3806	4507	4	,	,	PUNCT
fnp-3806	4507	5	hof	hof	PROPN
fnp-3806	4507	6	pr	pr	NOUN
fnp-3806	4507	7	,	,	PUNCT
fnp-3806	4507	8	vallet	vallet	NOUN
fnp-3806	4507	9	pg	pg	PROPN
fnp-3806	4507	10	,	,	PUNCT
fnp-3806	4507	11	et	et	PROPN
fnp-3806	4507	12	al	al	PROPN
fnp-3806	4507	13	.	.	PROPN
fnp-3806	4508	1	quantitative	quantitative	ADJ
fnp-3806	4508	2	analysis	analysis	NOUN
fnp-3806	4508	3	of	of	ADP
fnp-3806	4508	4	neuropathologic	neuropathologic	ADJ
fnp-3806	4508	5	changes	change	NOUN
fnp-3806	4508	6	in	in	ADP
fnp-3806	4508	7	the	the	DET
fnp-3806	4508	8	cerebral	cerebral	ADJ
fnp-3806	4508	9	cortex	cortex	NOUN
fnp-3806	4508	10	of	of	ADP
fnp-3806	4508	11	centenarians	centenarians	PROPN
fnp-3806	4508	12	.	.	PUNCT
fnp-3806	4509	1	prog	prog	PROPN
fnp-3806	4509	2	neuropsychopharmacol	neuropsychopharmacol	PROPN
fnp-3806	4509	3	biol	biol	PROPN
fnp-3806	4509	4	psychiatry	psychiatry	NOUN
fnp-3806	4509	5	1995;19:577	1995;19:577	PROPN
fnp-3806	4509	6	-	-	SYM
fnp-3806	4509	7	592	592	NUM
fnp-3806	4509	8	.	.	PUNCT
fnp-3806	4510	1	https://doi.org/10.1016/0278-5846(95)00103-3	https://doi.org/10.1016/0278-5846(95)00103-3	PROPN
fnp-3806	4510	2	rogalski	rogalski	PROPN
fnp-3806	4510	3	e	e	PROPN
fnp-3806	4510	4	,	,	PUNCT
fnp-3806	4510	5	gefen	gefen	PROPN
fnp-3806	4510	6	t	t	PROPN
fnp-3806	4510	7	,	,	PUNCT
fnp-3806	4510	8	mao	mao	X
fnp-3806	4511	1	q	q	NOUN
fnp-3806	4511	2	,	,	PUNCT
fnp-3806	4511	3	et	et	PROPN
fnp-3806	4511	4	al	al	PROPN
fnp-3806	4511	5	.	.	PROPN
fnp-3806	4511	6	cognitive	cognitive	ADJ
fnp-3806	4511	7	trajectories	trajectory	NOUN
fnp-3806	4511	8	and	and	CCONJ
fnp-3806	4511	9	spectrum	spectrum	NOUN
fnp-3806	4511	10	of	of	ADP
fnp-3806	4511	11	neuropathology	neuropathology	NOUN
fnp-3806	4511	12	in	in	ADP
fnp-3806	4511	13	superagers	superager	NOUN
fnp-3806	4511	14	:	:	PUNCT
fnp-3806	4511	15	the	the	DET
fnp-3806	4511	16	first	first	ADJ
fnp-3806	4511	17	10	10	NUM
fnp-3806	4511	18	cases	case	NOUN
fnp-3806	4511	19	.	.	PUNCT
fnp-3806	4512	1	hippocampus	hippocampus	NOUN
fnp-3806	4512	2	2019	2019	NUM
fnp-3806	4512	3	;	;	PUNCT
fnp-3806	4512	4	29:458	29:458	NUM
fnp-3806	4512	5	-	-	SYM
fnp-3806	4512	6	467	467	NUM
fnp-3806	4512	7	.	.	PUNCT
fnp-3806	4513	1	https://doi.org/10.1002/hipo.22828	https://doi.org/10.1002/hipo.22828	PROPN
fnp-3806	4513	2	xuereb	xuereb	PROPN
fnp-3806	4513	3	jh	jh	PROPN
fnp-3806	4513	4	,	,	PUNCT
fnp-3806	4513	5	brayne	brayne	PROPN
fnp-3806	4513	6	c	c	PROPN
fnp-3806	4513	7	,	,	PUNCT
fnp-3806	4513	8	dufouil	dufouil	PROPN
fnp-3806	4513	9	c	c	X
fnp-3806	4513	10	,	,	PUNCT
fnp-3806	4513	11	et	et	PROPN
fnp-3806	4513	12	al	al	PROPN
fnp-3806	4513	13	.	.	PUNCT
fnp-3806	4513	14	neuropathological	neuropathological	ADJ
fnp-3806	4513	15	findings	finding	NOUN
fnp-3806	4513	16	in	in	ADP
fnp-3806	4513	17	the	the	DET
fnp-3806	4513	18	very	very	ADV
fnp-3806	4513	19	old	old	ADJ
fnp-3806	4513	20	.	.	PUNCT
fnp-3806	4514	1	results	result	NOUN
fnp-3806	4514	2	from	from	ADP
fnp-3806	4514	3	the	the	DET
fnp-3806	4514	4	first	first	ADJ
fnp-3806	4514	5	101	101	NUM
fnp-3806	4514	6	brains	brain	NOUN
fnp-3806	4514	7	of	of	ADP
fnp-3806	4514	8	a	a	DET
fnp-3806	4514	9	population	population	NOUN
fnp-3806	4514	10	-	-	PUNCT
fnp-3806	4514	11	based	base	VERB
fnp-3806	4514	12	longitudinal	longitudinal	ADJ
fnp-3806	4514	13	study	study	NOUN
fnp-3806	4514	14	of	of	ADP
fnp-3806	4514	15	dementing	demente	VERB
fnp-3806	4514	16	disorders	disorder	NOUN
fnp-3806	4514	17	.	.	PUNCT
fnp-3806	4515	1	ann	ann	PROPN
fnp-3806	4515	2	n	n	PROPN
fnp-3806	4515	3	y	y	PROPN
fnp-3806	4515	4	acad	acad	PROPN
fnp-3806	4515	5	sci	sci	PROPN
fnp-3806	4515	6	2000;903:490	2000;903:490	NUM
fnp-3806	4515	7	-	-	SYM
fnp-3806	4515	8	496	496	NUM
fnp-3806	4515	9	.	.	PUNCT
fnp-3806	4516	1	https://doi.org/10.1111/j.1749-6632.2000.tb06404.x	https://doi.org/10.1111/j.1749-6632.2000.tb06404.x	PROPN
fnp-3806	4516	2	stern	stern	PROPN
fnp-3806	4516	3	y.	y.	PROPN
fnp-3806	4516	4	cognitive	cognitive	PROPN
fnp-3806	4516	5	reserve	reserve	PROPN
fnp-3806	4516	6	in	in	ADP
fnp-3806	4516	7	ageing	ageing	NOUN
fnp-3806	4516	8	and	and	CCONJ
fnp-3806	4516	9	alzheimer	alzheimer	NOUN
fnp-3806	4516	10	's	's	PART
fnp-3806	4516	11	disease	disease	NOUN
fnp-3806	4516	12	.	.	PUNCT
fnp-3806	4517	1	lancet	lancet	PROPN
fnp-3806	4517	2	neurol	neurol	NOUN
fnp-3806	4517	3	2012;11:1006	2012;11:1006	NUM
fnp-3806	4517	4	-	-	SYM
fnp-3806	4517	5	1012	1012	NUM
fnp-3806	4517	6	.	.	PUNCT
fnp-3806	4518	1	https://doi.org/10.1016/s1474-4422(12)70191-6	https://doi.org/10.1016/s1474-4422(12)70191-6	PROPN
fnp-3806	4518	2	lesuis	lesuis	PROPN
fnp-3806	4518	3	sl	sl	PROPN
fnp-3806	4518	4	,	,	PUNCT
fnp-3806	4518	5	hoeijmakers	hoeijmaker	NOUN
fnp-3806	4518	6	l	l	NOUN
fnp-3806	4518	7	,	,	PUNCT
fnp-3806	4518	8	korosi	korosi	PROPN
fnp-3806	4518	9	a	a	X
fnp-3806	4518	10	,	,	PUNCT
fnp-3806	4518	11	et	et	PROPN
fnp-3806	4518	12	al	al	PROPN
fnp-3806	4518	13	.	.	PROPN
fnp-3806	4518	14	vulnerability	vulnerability	NOUN
fnp-3806	4518	15	and	and	CCONJ
fnp-3806	4518	16	resilience	resilience	NOUN
fnp-3806	4518	17	to	to	ADP
fnp-3806	4518	18	alzheimer	alzheimer	PROPN
fnp-3806	4518	19	's	's	PART
fnp-3806	4518	20	disease	disease	NOUN
fnp-3806	4518	21	:	:	PUNCT
fnp-3806	4518	22	early	early	ADJ
fnp-3806	4518	23	life	life	NOUN
fnp-3806	4518	24	conditions	condition	NOUN
fnp-3806	4518	25	modulate	modulate	VERB
fnp-3806	4518	26	neuropathology	neuropathology	NOUN
fnp-3806	4518	27	and	and	CCONJ
fnp-3806	4518	28	determine	determine	VERB
fnp-3806	4518	29	cognitive	cognitive	ADJ
fnp-3806	4518	30	reserve	reserve	NOUN
fnp-3806	4518	31	.	.	PUNCT
fnp-3806	4519	1	alzheimers	alzheimer	NOUN
fnp-3806	4519	2	res	re	VERB
fnp-3806	4519	3	ther	ther	ADV
fnp-3806	4519	4	2018;10:95	2018;10:95	NUM
fnp-3806	4519	5	.	.	PUNCT
fnp-3806	4520	1	https://doi.org/10.1186/s13195-018-0422-7	https://doi.org/10.1186/s13195-018-0422-7	PROPN
fnp-3806	4520	2	montine	montine	PROPN
fnp-3806	4520	3	tj	tj	PROPN
fnp-3806	4520	4	,	,	PUNCT
fnp-3806	4520	5	cholerton	cholerton	PROPN
fnp-3806	4520	6	ba	ba	PROPN
fnp-3806	4520	7	,	,	PUNCT
fnp-3806	4520	8	corrada	corrada	PROPN
fnp-3806	4520	9	mm	mm	PROPN
fnp-3806	4520	10	,	,	PUNCT
fnp-3806	4520	11	et	et	PROPN
fnp-3806	4520	12	al	al	PROPN
fnp-3806	4520	13	.	.	PUNCT
fnp-3806	4520	14	concepts	concept	NOUN
fnp-3806	4520	15	for	for	ADP
fnp-3806	4520	16	brain	brain	NOUN
fnp-3806	4520	17	aging	aging	NOUN
fnp-3806	4520	18	:	:	PUNCT
fnp-3806	4520	19	resistance	resistance	NOUN
fnp-3806	4520	20	,	,	PUNCT
fnp-3806	4520	21	resilience	resilience	NOUN
fnp-3806	4520	22	,	,	PUNCT
fnp-3806	4520	23	reserve	reserve	NOUN
fnp-3806	4520	24	,	,	PUNCT
fnp-3806	4520	25	and	and	CCONJ
fnp-3806	4520	26	compensation	compensation	NOUN
fnp-3806	4520	27	.	.	PUNCT
fnp-3806	4521	1	alzheimers	alzheimer	NOUN
fnp-3806	4521	2	res	re	VERB
fnp-3806	4521	3	ther	ther	PROPN
fnp-3806	4521	4	2019;11:22	2019;11:22	NUM
fnp-3806	4521	5	.	.	PUNCT
fnp-3806	4522	1	https://doi.org/10.1186/s13195-019-0479-y	https://doi.org/10.1186/s13195-019-0479-y	PROPN
fnp-3806	4522	2	weisenbach	weisenbach	NOUN
fnp-3806	4522	3	sl	sl	PROPN
fnp-3806	4522	4	,	,	PUNCT
fnp-3806	4522	5	kim	kim	PROPN
fnp-3806	4522	6	j	j	PROPN
fnp-3806	4522	7	,	,	PUNCT
fnp-3806	4522	8	hammers	hammers	PROPN
fnp-3806	4522	9	d	d	PROPN
fnp-3806	4522	10	,	,	PUNCT
fnp-3806	4522	11	et	et	PROPN
fnp-3806	4522	12	al	al	PROPN
fnp-3806	4522	13	.	.	PUNCT
fnp-3806	4523	1	linking	link	VERB
fnp-3806	4523	2	late	late	ADJ
fnp-3806	4523	3	life	life	NOUN
fnp-3806	4523	4	depression	depression	NOUN
fnp-3806	4523	5	and	and	CCONJ
fnp-3806	4523	6	alzheimer	alzheimer	PROPN
fnp-3806	4523	7	's	's	PART
fnp-3806	4523	8	disease	disease	NOUN
fnp-3806	4523	9	:	:	PUNCT
fnp-3806	4523	10	mechanisms	mechanism	NOUN
fnp-3806	4523	11	and	and	CCONJ
fnp-3806	4523	12	resilience	resilience	NOUN
fnp-3806	4523	13	.	.	PUNCT
fnp-3806	4524	1	curr	curr	PROPN
fnp-3806	4524	2	behav	behav	PROPN
fnp-3806	4524	3	neurosci	neurosci	PROPN
fnp-3806	4524	4	rep	rep	PROPN
fnp-3806	4524	5	2019;6:103	2019;6:103	PROPN
fnp-3806	4524	6	-	-	SYM
fnp-3806	4524	7	112	112	NUM
fnp-3806	4524	8	.	.	PUNCT
fnp-3806	4525	1	https://doi.org/10.1007/s40473-019-00180-7	https://doi.org/10.1007/s40473-019-00180-7	NUM
fnp-3806	4525	2	peng	peng	PROPN
fnp-3806	4525	3	s	s	PROPN
fnp-3806	4525	4	,	,	PUNCT
fnp-3806	4525	5	roth	roth	PROPN
fnp-3806	4525	6	ar	ar	PROPN
fnp-3806	4525	7	,	,	PUNCT
fnp-3806	4525	8	apostolova	apostolova	VERB
fnp-3806	4525	9	lg	lg	PROPN
fnp-3806	4525	10	,	,	PUNCT
fnp-3806	4525	11	et	et	PROPN
fnp-3806	4525	12	al	al	PROPN
fnp-3806	4525	13	.	.	PROPN
fnp-3806	4526	1	cognitively	cognitively	ADV
fnp-3806	4526	2	stimulating	stimulate	VERB
fnp-3806	4526	3	environments	environment	NOUN
fnp-3806	4526	4	and	and	CCONJ
fnp-3806	4526	5	cognitive	cognitive	ADJ
fnp-3806	4526	6	reserve	reserve	NOUN
fnp-3806	4526	7	:	:	PUNCT
fnp-3806	4526	8	the	the	DET
fnp-3806	4526	9	case	case	NOUN
fnp-3806	4526	10	of	of	ADP
fnp-3806	4526	11	personal	personal	ADJ
fnp-3806	4526	12	social	social	ADJ
fnp-3806	4526	13	networks	network	NOUN
fnp-3806	4526	14	.	.	PUNCT
fnp-3806	4527	1	neurobiol	neurobiol	ADJ
fnp-3806	4527	2	aging	age	VERB
fnp-3806	4527	3	2022;112	2022;112	NUM
fnp-3806	4527	4	:	:	PUNCT
fnp-3806	4527	5	197	197	NUM
fnp-3806	4527	6	-	-	SYM
fnp-3806	4527	7	203	203	NUM
fnp-3806	4527	8	.	.	PUNCT
fnp-3806	4528	1	https://doi.org/10.1016/j.neurobiolaging.2022.01.004	https://doi.org/10.1016/j.neurobiolaging.2022.01.004	PROPN
fnp-3806	4528	2	zhang	zhang	PROPN
fnp-3806	4528	3	x	x	PROPN
fnp-3806	4528	4	,	,	PUNCT
fnp-3806	4528	5	alshakhshir	alshakhshir	ADV
fnp-3806	4528	6	n	n	CCONJ
fnp-3806	4528	7	,	,	PUNCT
fnp-3806	4528	8	zhao	zhao	PROPN
fnp-3806	4528	9	l.	l.	PROPN
fnp-3806	4528	10	glycolytic	glycolytic	ADJ
fnp-3806	4528	11	metabolism	metabolism	NOUN
fnp-3806	4528	12	,	,	PUNCT
fnp-3806	4528	13	brain	brain	NOUN
fnp-3806	4528	14	resilience	resilience	NOUN
fnp-3806	4528	15	,	,	PUNCT
fnp-3806	4528	16	and	and	CCONJ
fnp-3806	4528	17	alzheimer	alzheimer	PROPN
fnp-3806	4528	18	's	's	PART
fnp-3806	4528	19	disease	disease	NOUN
fnp-3806	4528	20	.	.	PUNCT
fnp-3806	4529	1	front	front	ADJ
fnp-3806	4529	2	neurosci	neurosci	PROPN
fnp-3806	4529	3	2021;15:662242	2021;15:662242	X
fnp-3806	4529	4	.	.	PUNCT
fnp-3806	4530	1	https://doi.org/10.3389/fnins.2021.662242	https://doi.org/10.3389/fnins.2021.662242	PROPN
fnp-3806	4530	2	camandola	camandola	NOUN
fnp-3806	4530	3	s	s	NOUN
fnp-3806	4530	4	,	,	PUNCT
fnp-3806	4530	5	plick	plick	NOUN
fnp-3806	4530	6	n	n	PROPN
fnp-3806	4530	7	,	,	PUNCT
fnp-3806	4530	8	mattson	mattson	PROPN
fnp-3806	4530	9	mp	mp	PROPN
fnp-3806	4530	10	.	.	PROPN
fnp-3806	4530	11	impact	impact	NOUN
fnp-3806	4530	12	of	of	ADP
fnp-3806	4530	13	coffee	coffee	NOUN
fnp-3806	4530	14	and	and	CCONJ
fnp-3806	4530	15	cacao	cacao	NOUN
fnp-3806	4530	16	metabolites	metabolite	NOUN
fnp-3806	4530	17	on	on	ADP
fnp-3806	4530	18	neuroplasticity	neuroplasticity	NOUN
fnp-3806	4530	19	and	and	CCONJ
fnp-3806	4530	20	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4530	21	disease	disease	NOUN
fnp-3806	4530	22	.	.	PUNCT
fnp-3806	4531	1	neurochem	neurochem	PROPN
fnp-3806	4531	2	res	re	VERB
fnp-3806	4531	3	2019;44:214	2019;44:214	NUM
fnp-3806	4531	4	-	-	SYM
fnp-3806	4531	5	227	227	NUM
fnp-3806	4531	6	.	.	PUNCT
fnp-3806	4532	1	https://doi.org/10.1007/s11064-018-2492-0	https://doi.org/10.1007/s11064-018-2492-0	PROPN
fnp-3806	4533	1	aiello	aiello	PROPN
fnp-3806	4533	2	bowles	bowles	PROPN
fnp-3806	4533	3	ej	ej	PROPN
fnp-3806	4533	4	,	,	PUNCT
fnp-3806	4533	5	crane	crane	NOUN
fnp-3806	4533	6	pk	pk	PROPN
fnp-3806	4533	7	,	,	PUNCT
fnp-3806	4533	8	walker	walker	PROPN
fnp-3806	4533	9	rl	rl	PROPN
fnp-3806	4533	10	,	,	PUNCT
fnp-3806	4533	11	et	et	PROPN
fnp-3806	4533	12	al	al	PROPN
fnp-3806	4533	13	.	.	PROPN
fnp-3806	4533	14	cognitive	cognitive	ADJ
fnp-3806	4533	15	resilience	resilience	NOUN
fnp-3806	4533	16	to	to	ADP
fnp-3806	4533	17	alzheimer	alzheimer	PROPN
fnp-3806	4533	18	’s	’s	PART
fnp-3806	4533	19	disease	disease	NOUN
fnp-3806	4533	20	pathology	pathology	NOUN
fnp-3806	4533	21	in	in	ADP
fnp-3806	4533	22	the	the	DET
fnp-3806	4533	23	human	human	ADJ
fnp-3806	4533	24	brain	brain	NOUN
fnp-3806	4533	25	.	.	PUNCT
fnp-3806	4534	1	j	j	PROPN
fnp-3806	4534	2	alzheimers	alzheimers	PROPN
fnp-3806	4534	3	dis	dis	PROPN
fnp-3806	4535	1	2019;68:1071	2019;68:1071	PROPN
fnp-3806	4535	2	-	-	SYM
fnp-3806	4535	3	1083	1083	NUM
fnp-3806	4535	4	.	.	PUNCT
fnp-3806	4536	1	https://doi.org/10.3233/jad-180942	https://doi.org/10.3233/jad-180942	NUM
fnp-3806	4536	2	buciuc	buciuc	PROPN
fnp-3806	4536	3	m	m	PROPN
fnp-3806	4536	4	,	,	PUNCT
fnp-3806	4536	5	wennberg	wennberg	PROPN
fnp-3806	4536	6	am	be	AUX
fnp-3806	4536	7	,	,	PUNCT
fnp-3806	4536	8	weigand	weigand	NOUN
fnp-3806	4536	9	sd	sd	NOUN
fnp-3806	4536	10	,	,	PUNCT
fnp-3806	4537	1	et	et	PROPN
fnp-3806	4537	2	al	al	PROPN
fnp-3806	4537	3	.	.	PROPN
fnp-3806	4537	4	effect	effect	NOUN
fnp-3806	4537	5	modifiers	modifier	NOUN
fnp-3806	4537	6	of	of	ADP
fnp-3806	4537	7	tdp-43	tdp-43	NOUN
fnp-3806	4537	8	-	-	PUNCT
fnp-3806	4537	9	associated	associate	VERB
fnp-3806	4537	10	hippocampal	hippocampal	ADJ
fnp-3806	4537	11	atrophy	atrophy	NOUN
fnp-3806	4537	12	rates	rate	NOUN
fnp-3806	4537	13	in	in	ADP
fnp-3806	4537	14	patients	patient	NOUN
fnp-3806	4537	15	with	with	ADP
fnp-3806	4537	16	alzheimer	alzheimer	PROPN
fnp-3806	4537	17	's	's	PART
fnp-3806	4537	18	disease	disease	NOUN
fnp-3806	4537	19	neuropathological	neuropathological	ADJ
fnp-3806	4537	20	changes	change	NOUN
fnp-3806	4537	21	.	.	PUNCT
fnp-3806	4538	1	j	j	PROPN
fnp-3806	4538	2	alzheimers	alzheimers	PROPN
fnp-3806	4538	3	dis	dis	PROPN
fnp-3806	4538	4	2020a;73:1511	2020a;73:1511	PROPN
fnp-3806	4538	5	-	-	SYM
fnp-3806	4538	6	1523	1523	NUM
fnp-3806	4538	7	.	.	PUNCT
fnp-3806	4538	8	https://doi.org/10.3233/jad-191040	https://doi.org/10.3233/jad-191040	VERB
fnp-3806	4538	9	buciuc	buciuc	PROPN
fnp-3806	4538	10	m	m	PROPN
fnp-3806	4538	11	,	,	PUNCT
fnp-3806	4538	12	whitwell	whitwell	ADJ
fnp-3806	4538	13	jl	jl	NOUN
fnp-3806	4538	14	,	,	PUNCT
fnp-3806	4538	15	tosakulwong	tosakulwong	ADP
fnp-3806	4538	16	n	n	CCONJ
fnp-3806	4538	17	,	,	PUNCT
fnp-3806	4538	18	et	et	PROPN
fnp-3806	4538	19	al	al	PROPN
fnp-3806	4538	20	.	.	PROPN
fnp-3806	4538	21	association	association	PROPN
fnp-3806	4538	22	between	between	ADP
fnp-3806	4538	23	transactive	transactive	ADJ
fnp-3806	4538	24	response	response	NOUN
fnp-3806	4538	25	dna	dna	NOUN
fnp-3806	4538	26	-	-	PUNCT
fnp-3806	4538	27	binding	bind	VERB
fnp-3806	4538	28	protein	protein	NOUN
fnp-3806	4538	29	of	of	ADP
fnp-3806	4538	30	43	43	NUM
fnp-3806	4538	31	kda	kda	NOUN
fnp-3806	4538	32	type	type	NOUN
fnp-3806	4538	33	and	and	CCONJ
fnp-3806	4538	34	cognitive	cognitive	ADJ
fnp-3806	4538	35	resilience	resilience	NOUN
fnp-3806	4538	36	to	to	ADP
fnp-3806	4538	37	alzheimer	alzheimer	PROPN
fnp-3806	4538	38	's	's	PART
fnp-3806	4538	39	disease	disease	NOUN
fnp-3806	4538	40	:	:	PUNCT
fnp-3806	4538	41	a	a	DET
fnp-3806	4538	42	case	case	NOUN
fnp-3806	4538	43	-	-	PUNCT
fnp-3806	4538	44	control	control	NOUN
fnp-3806	4538	45	study	study	NOUN
fnp-3806	4538	46	.	.	PUNCT
fnp-3806	4539	1	neurobiol	neurobiol	PROPN
fnp-3806	4539	2	aging	age	VERB
fnp-3806	4539	3	2020b;92:92	2020b;92:92	NUM
fnp-3806	4539	4	-	-	SYM
fnp-3806	4539	5	97	97	NUM
fnp-3806	4539	6	.	.	PUNCT
fnp-3806	4540	1	https://doi.org/10.1016/j.neurobiolaging.2020.04.001	https://doi.org/10.1016/j.neurobiolaging.2020.04.001	VERB
fnp-3806	4540	2	nygaard	nygaard	NOUN
fnp-3806	4540	3	hb	hb	PROPN
fnp-3806	4540	4	,	,	PUNCT
fnp-3806	4540	5	erson	erson	PROPN
fnp-3806	4540	6	-	-	PUNCT
fnp-3806	4540	7	omay	omay	PROPN
fnp-3806	4540	8	ez	ez	PROPN
fnp-3806	4540	9	,	,	PUNCT
fnp-3806	4540	10	wu	wu	PROPN
fnp-3806	4540	11	x	x	PROPN
fnp-3806	4540	12	,	,	PUNCT
fnp-3806	4540	13	et	et	PROPN
fnp-3806	4540	14	al	al	PROPN
fnp-3806	4540	15	.	.	PUNCT
fnp-3806	4541	1	whole	whole	ADJ
fnp-3806	4541	2	-	-	PUNCT
fnp-3806	4541	3	exome	exome	NOUN
fnp-3806	4541	4	sequencing	sequencing	NOUN
fnp-3806	4541	5	of	of	ADP
fnp-3806	4541	6	an	an	DET
fnp-3806	4541	7	exceptional	exceptional	ADJ
fnp-3806	4541	8	longevity	longevity	NOUN
fnp-3806	4541	9	cohort	cohort	NOUN
fnp-3806	4541	10	.	.	PUNCT
fnp-3806	4542	1	j	j	PROPN
fnp-3806	4542	2	gerontol	gerontol	VERB
fnp-3806	4542	3	a	a	DET
fnp-3806	4542	4	biol	biol	PROPN
fnp-3806	4542	5	sci	sci	PROPN
fnp-3806	4542	6	med	med	PROPN
fnp-3806	4542	7	sci	sci	PROPN
fnp-3806	4542	8	2019;74:1386	2019;74:1386	NUM
fnp-3806	4542	9	-	-	SYM
fnp-3806	4542	10	1390	1390	NUM
fnp-3806	4542	11	.	.	PUNCT
fnp-3806	4543	1	https://doi.org/10.1093/gerona/gly098	https://doi.org/10.1093/gerona/gly098	PROPN
fnp-3806	4543	2	seto	seto	PROPN
fnp-3806	4543	3	m	m	NOUN
fnp-3806	4543	4	,	,	PUNCT
fnp-3806	4543	5	weiner	weiner	NOUN
fnp-3806	4543	6	rl	rl	PROPN
fnp-3806	4543	7	,	,	PUNCT
fnp-3806	4543	8	dumitrescu	dumitrescu	PROPN
fnp-3806	4543	9	l	l	PROPN
fnp-3806	4543	10	,	,	PUNCT
fnp-3806	4543	11	et	et	PROPN
fnp-3806	4543	12	al	al	PROPN
fnp-3806	4543	13	.	.	PUNCT
fnp-3806	4543	14	protective	protective	ADJ
fnp-3806	4543	15	genes	gene	NOUN
fnp-3806	4543	16	and	and	CCONJ
fnp-3806	4543	17	pathways	pathway	NOUN
fnp-3806	4543	18	in	in	ADP
fnp-3806	4543	19	alzheimer	alzheimer	PROPN
fnp-3806	4543	20	's	's	PART
fnp-3806	4543	21	disease	disease	NOUN
fnp-3806	4543	22	:	:	PUNCT
fnp-3806	4543	23	moving	move	VERB
fnp-3806	4543	24	towards	towards	ADP
fnp-3806	4543	25	precision	precision	NOUN
fnp-3806	4543	26	interventions	intervention	NOUN
fnp-3806	4543	27	.	.	PUNCT
fnp-3806	4544	1	mol	mol	ADP
fnp-3806	4544	2	neurodegener	neurodegener	NOUN
fnp-3806	4544	3	2021	2021	NUM
fnp-3806	4544	4	;	;	PUNCT
fnp-3806	4544	5	16:29	16:29	NUM
fnp-3806	4544	6	.	.	PUNCT
fnp-3806	4544	7	https://doi.org/10.1186/s13024-021-00452-5	https://doi.org/10.1186/s13024-021-00452-5	PROPN
fnp-3806	4544	8	mcdermott	mcdermott	PROPN
fnp-3806	4544	9	kl	kl	PROPN
fnp-3806	4544	10	,	,	PUNCT
fnp-3806	4544	11	mcfall	mcfall	PROPN
fnp-3806	4544	12	gp	gp	PROPN
fnp-3806	4544	13	,	,	PUNCT
fnp-3806	4544	14	andrews	andrews	PROPN
fnp-3806	4544	15	sj	sj	PROPN
fnp-3806	4544	16	,	,	PUNCT
fnp-3806	4544	17	et	et	PROPN
fnp-3806	4544	18	al	al	PROPN
fnp-3806	4544	19	.	.	PROPN
fnp-3806	4544	20	memory	memory	NOUN
fnp-3806	4544	21	resilience	resilience	PROPN
fnp-3806	4544	22	to	to	ADP
fnp-3806	4544	23	alzheimer	alzheimer	PROPN
fnp-3806	4544	24	’s	’s	PART
fnp-3806	4544	25	genetic	genetic	ADJ
fnp-3806	4544	26	risk	risk	NOUN
fnp-3806	4544	27	:	:	PUNCT
fnp-3806	4544	28	sex	sex	NOUN
fnp-3806	4544	29	effects	effect	NOUN
fnp-3806	4544	30	in	in	ADP
fnp-3806	4544	31	predictor	predictor	NOUN
fnp-3806	4544	32	profiles	profile	NOUN
fnp-3806	4544	33	.	.	PUNCT
fnp-3806	4545	1	j	j	PROPN
fnp-3806	4545	2	gerontol	gerontol	PROPN
fnp-3806	4545	3	b	b	PROPN
fnp-3806	4545	4	psychol	psychol	PROPN
fnp-3806	4545	5	sci	sci	PROPN
fnp-3806	4545	6	soc	soc	PROPN
fnp-3806	4545	7	sci	sci	PROPN
fnp-3806	4545	8	2017;72:937	2017;72:937	PROPN
fnp-3806	4545	9	-	-	NOUN
fnp-3806	4545	10	946	946	NUM
fnp-3806	4545	11	.	.	PUNCT
fnp-3806	4546	1	https://doi.org/10.1093/geronb/gbw161	https://doi.org/10.1093/geronb/gbw161	ADJ
fnp-3806	4546	2	dumitrescu	dumitrescu	PROPN
fnp-3806	4546	3	l	l	PROPN
fnp-3806	4546	4	,	,	PUNCT
fnp-3806	4546	5	mahoney	mahoney	PROPN
fnp-3806	4546	6	er	er	INTJ
fnp-3806	4546	7	,	,	PUNCT
fnp-3806	4546	8	mukherjee	mukherjee	PROPN
fnp-3806	4546	9	s	s	PROPN
fnp-3806	4546	10	,	,	PUNCT
fnp-3806	4546	11	et	et	PROPN
fnp-3806	4546	12	al	al	PROPN
fnp-3806	4546	13	.	.	PUNCT
fnp-3806	4547	1	genetic	genetic	ADJ
fnp-3806	4547	2	variants	variant	NOUN
fnp-3806	4547	3	and	and	CCONJ
fnp-3806	4547	4	functional	functional	ADJ
fnp-3806	4547	5	pathways	pathway	NOUN
fnp-3806	4547	6	associated	associate	VERB
fnp-3806	4547	7	with	with	ADP
fnp-3806	4547	8	resilience	resilience	NOUN
fnp-3806	4547	9	to	to	ADP
fnp-3806	4547	10	alzheimer	alzheimer	PROPN
fnp-3806	4547	11	’s	’s	PART
fnp-3806	4547	12	disease	disease	NOUN
fnp-3806	4547	13	.	.	PUNCT
fnp-3806	4548	1	brain	brain	NOUN
fnp-3806	4548	2	2020;143:2561	2020;143:2561	NUM
fnp-3806	4548	3	-	-	SYM
fnp-3806	4548	4	2575	2575	NUM
fnp-3806	4548	5	.	.	PUNCT
fnp-3806	4549	1	https://doi.org/10.1093/brain/awaa209	https://doi.org/10.1093/brain/awaa209	NOUN
fnp-3806	4549	2	tavana	tavana	PROPN
fnp-3806	4549	3	jp	jp	PROPN
fnp-3806	4549	4	,	,	PUNCT
fnp-3806	4549	5	rosene	rosene	NOUN
fnp-3806	4549	6	m	m	PROPN
fnp-3806	4549	7	,	,	PUNCT
fnp-3806	4549	8	jensen	jensen	PROPN
fnp-3806	4549	9	no	no	PROPN
fnp-3806	4549	10	,	,	PUNCT
fnp-3806	4549	11	et	et	PROPN
fnp-3806	4549	12	al	al	PROPN
fnp-3806	4549	13	.	.	PROPN
fnp-3806	4549	14	rab10	rab10	PROPN
fnp-3806	4549	15	an	an	DET
fnp-3806	4549	16	alzheimer	alzheimer	PROPN
fnp-3806	4549	17	’s	’s	PART
fnp-3806	4549	18	disease	disease	NOUN
fnp-3806	4549	19	resilience	resilience	NOUN
fnp-3806	4549	20	locus	locus	NOUN
fnp-3806	4549	21	and	and	CCONJ
fnp-3806	4549	22	potential	potential	ADJ
fnp-3806	4549	23	drug	drug	NOUN
fnp-3806	4549	24	target	target	NOUN
fnp-3806	4549	25	.	.	PUNCT
fnp-3806	4550	1	clin	clin	PROPN
fnp-3806	4550	2	interv	interv	VERB
fnp-3806	4550	3	aging	age	VERB
fnp-3806	4550	4	2018	2018	NUM
fnp-3806	4550	5	;	;	PUNCT
fnp-3806	4550	6	14	14	NUM
fnp-3806	4550	7	:	:	SYM
fnp-3806	4550	8	73	73	NUM
fnp-3806	4550	9	-	-	SYM
fnp-3806	4550	10	79	79	NUM
fnp-3806	4550	11	.	.	PUNCT
fnp-3806	4550	12	https://doi.org/10.2147/cia.s159148	https://doi.org/10.2147/cia.s159148	X
fnp-3806	4550	13	neuner	neuner	PROPN
fnp-3806	4550	14	sm	sm	PROPN
fnp-3806	4550	15	,	,	PUNCT
fnp-3806	4550	16	wilmott	wilmott	PROPN
fnp-3806	4550	17	la	la	PROPN
fnp-3806	4550	18	,	,	PUNCT
fnp-3806	4550	19	hoffmann	hoffmann	PROPN
fnp-3806	4550	20	br	br	PROPN
fnp-3806	4550	21	,	,	PUNCT
fnp-3806	4550	22	et	et	PROPN
fnp-3806	4550	23	al	al	PROPN
fnp-3806	4550	24	.	.	PROPN
fnp-3806	4550	25	hippocampal	hippocampal	PROPN
fnp-3806	4550	26	proteomics	proteomic	NOUN
fnp-3806	4550	27	defines	define	VERB
fnp-3806	4550	28	pathways	pathway	NOUN
fnp-3806	4550	29	associated	associate	VERB
fnp-3806	4550	30	with	with	ADP
fnp-3806	4550	31	memory	memory	NOUN
fnp-3806	4550	32	decline	decline	NOUN
fnp-3806	4550	33	and	and	CCONJ
fnp-3806	4550	34	resilience	resilience	NOUN
fnp-3806	4550	35	in	in	ADP
fnp-3806	4550	36	normal	normal	ADJ
fnp-3806	4550	37	aging	aging	NOUN
fnp-3806	4550	38	and	and	CCONJ
fnp-3806	4550	39	alzheimer	alzheimer	PROPN
fnp-3806	4550	40	's	's	PART
fnp-3806	4550	41	disease	disease	NOUN
fnp-3806	4550	42	mouse	mouse	NOUN
fnp-3806	4550	43	models	model	NOUN
fnp-3806	4550	44	.	.	PUNCT
fnp-3806	4551	1	behav	behav	NOUN
fnp-3806	4551	2	brain	brain	NOUN
fnp-3806	4551	3	res	re	NOUN
fnp-3806	4551	4	2017;322:288	2017;322:288	NUM
fnp-3806	4551	5	-	-	SYM
fnp-3806	4551	6	298	298	NUM
fnp-3806	4551	7	.	.	PUNCT
fnp-3806	4552	1	https://doi.org/10.1016/j.bbr.2016.06.002	https://doi.org/10.1016/j.bbr.2016.06.002	VERB
fnp-3806	4552	2	leng	leng	PROPN
fnp-3806	4552	3	k	k	PROPN
fnp-3806	4552	4	,	,	PUNCT
fnp-3806	4552	5	li	li	PROPN
fnp-3806	4552	6	e	e	PROPN
fnp-3806	4552	7	,	,	PUNCT
fnp-3806	4552	8	eser	eser	NOUN
fnp-3806	4552	9	r	r	NOUN
fnp-3806	4552	10	,	,	PUNCT
fnp-3806	4552	11	et	et	PROPN
fnp-3806	4552	12	al	al	PROPN
fnp-3806	4552	13	.	.	PUNCT
fnp-3806	4553	1	molecular	molecular	ADJ
fnp-3806	4553	2	characterization	characterization	NOUN
fnp-3806	4553	3	of	of	ADP
fnp-3806	4553	4	selectively	selectively	ADV
fnp-3806	4553	5	vulnerable	vulnerable	ADJ
fnp-3806	4553	6	neurons	neuron	NOUN
fnp-3806	4553	7	in	in	ADP
fnp-3806	4553	8	alzheimer	alzheimer	PROPN
fnp-3806	4553	9	's	's	PART
fnp-3806	4553	10	disease	disease	NOUN
fnp-3806	4553	11	.	.	PUNCT
fnp-3806	4554	1	nat	nat	PROPN
fnp-3806	4554	2	neurosci	neurosci	PROPN
fnp-3806	4554	3	2021;24:276	2021;24:276	PROPN
fnp-3806	4554	4	-	-	SYM
fnp-3806	4554	5	287	287	NUM
fnp-3806	4554	6	.	.	PUNCT
fnp-3806	4555	1	https://doi.org/10.1038/s41593-020-00764-7	https://doi.org/10.1038/s41593-020-00764-7	PROPN
fnp-3806	4556	1	barker	barker	PROPN
fnp-3806	4556	2	sj	sj	PROPN
fnp-3806	4556	3	,	,	PUNCT
fnp-3806	4556	4	raju	raju	PROPN
fnp-3806	4556	5	rm	rm	PROPN
fnp-3806	4556	6	,	,	PUNCT
fnp-3806	4556	7	milman	milman	NOUN
fnp-3806	4556	8	nep	nep	PROPN
fnp-3806	4556	9	,	,	PUNCT
fnp-3806	4556	10	et	et	PROPN
fnp-3806	4556	11	al	al	PROPN
fnp-3806	4556	12	.	.	PUNCT
fnp-3806	4557	1	mef2	mef2	PROPN
fnp-3806	4557	2	is	be	AUX
fnp-3806	4557	3	a	a	DET
fnp-3806	4557	4	key	key	ADJ
fnp-3806	4557	5	regulator	regulator	NOUN
fnp-3806	4557	6	of	of	ADP
fnp-3806	4557	7	cognitive	cognitive	ADJ
fnp-3806	4557	8	potential	potential	NOUN
fnp-3806	4557	9	and	and	CCONJ
fnp-3806	4557	10	confers	confer	NOUN
fnp-3806	4557	11	resilience	resilience	NOUN
fnp-3806	4557	12	to	to	ADP
fnp-3806	4557	13	neurodegeneration	neurodegeneration	NOUN
fnp-3806	4557	14	.	.	PUNCT
fnp-3806	4558	1	sci	sci	PROPN
fnp-3806	4558	2	transl	transl	PROPN
fnp-3806	4558	3	med	med	PROPN
fnp-3806	4558	4	2020;13	2020;13	NUM
fnp-3806	4558	5	:	:	PUNCT
fnp-3806	4558	6	eabd7695	eabd7695	PROPN
fnp-3806	4558	7	.	.	PUNCT
fnp-3806	4559	1	https://doi.org/10.1126/scitranslmed.abd7695	https://doi.org/10.1126/scitranslmed.abd7695	PROPN
fnp-3806	4559	2	tesi	tesi	PROPN
fnp-3806	4559	3	n	n	CCONJ
fnp-3806	4559	4	,	,	PUNCT
fnp-3806	4559	5	van	van	PROPN
fnp-3806	4559	6	der	der	NOUN
fnp-3806	4559	7	lee	lee	PROPN
fnp-3806	4559	8	sj	sj	PROPN
fnp-3806	4559	9	,	,	PUNCT
fnp-3806	4559	10	hulsman	hulsman	PROPN
fnp-3806	4559	11	m	m	PROPN
fnp-3806	4559	12	,	,	PUNCT
fnp-3806	4559	13	et	et	PROPN
fnp-3806	4559	14	al	al	PROPN
fnp-3806	4559	15	.	.	PROPN
fnp-3806	4559	16	immune	immune	ADJ
fnp-3806	4559	17	response	response	NOUN
fnp-3806	4559	18	and	and	CCONJ
fnp-3806	4559	19	endocytosis	endocytosis	NOUN
fnp-3806	4559	20	pathways	pathway	NOUN
fnp-3806	4559	21	are	be	AUX
fnp-3806	4559	22	associated	associate	VERB
fnp-3806	4559	23	with	with	ADP
fnp-3806	4559	24	the	the	DET
fnp-3806	4559	25	resilience	resilience	NOUN
fnp-3806	4559	26	against	against	ADP
fnp-3806	4559	27	alzheimer	alzheimer	PROPN
fnp-3806	4559	28	's	's	PART
fnp-3806	4559	29	disease	disease	NOUN
fnp-3806	4559	30	.	.	PUNCT
fnp-3806	4560	1	transl	transl	PROPN
fnp-3806	4560	2	psychiatry	psychiatry	NOUN
fnp-3806	4560	3	2020;10:332	2020;10:332	PROPN
fnp-3806	4560	4	.	.	PUNCT
fnp-3806	4561	1	https://doi.org/10.1038/s41398-020-01018-7	https://doi.org/10.1038/s41398-020-01018-7	X
fnp-3806	4561	2	perneczky	perneczky	ADJ
fnp-3806	4561	3	r	r	NOUN
fnp-3806	4561	4	,	,	PUNCT
fnp-3806	4561	5	kempermann	kempermann	PROPN
fnp-3806	4561	6	g	g	PROPN
fnp-3806	4561	7	,	,	PUNCT
fnp-3806	4561	8	korczyn	korczyn	NOUN
fnp-3806	4561	9	ad	ad	NOUN
fnp-3806	4561	10	,	,	PUNCT
fnp-3806	4561	11	et	et	PROPN
fnp-3806	4561	12	al	al	PROPN
fnp-3806	4561	13	.	.	PUNCT
fnp-3806	4562	1	translational	translational	ADJ
fnp-3806	4562	2	research	research	NOUN
fnp-3806	4562	3	on	on	ADP
fnp-3806	4562	4	reserve	reserve	NOUN
fnp-3806	4562	5	against	against	ADP
fnp-3806	4562	6	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4562	7	disease	disease	NOUN
fnp-3806	4562	8	:	:	PUNCT
fnp-3806	4562	9	consensus	consensus	NOUN
fnp-3806	4562	10	report	report	NOUN
fnp-3806	4562	11	of	of	ADP
fnp-3806	4562	12	the	the	DET
fnp-3806	4562	13	international	international	ADJ
fnp-3806	4562	14	conference	conference	NOUN
fnp-3806	4562	15	on	on	ADP
fnp-3806	4562	16	cognitive	cognitive	ADJ
fnp-3806	4562	17	reserve	reserve	NOUN
fnp-3806	4562	18	in	in	ADP
fnp-3806	4562	19	the	the	DET
fnp-3806	4562	20	dementias	dementia	NOUN
fnp-3806	4562	21	and	and	CCONJ
fnp-3806	4562	22	the	the	DET
fnp-3806	4562	23	alzheimer	alzheimer	PROPN
fnp-3806	4562	24	's	's	PART
fnp-3806	4562	25	association	association	PROPN
fnp-3806	4562	26	reserve	reserve	PROPN
fnp-3806	4562	27	,	,	PUNCT
fnp-3806	4562	28	resilience	resilience	NOUN
fnp-3806	4562	29	and	and	CCONJ
fnp-3806	4562	30	protective	protective	ADJ
fnp-3806	4562	31	factors	factor	NOUN
fnp-3806	4562	32	professional	professional	ADJ
fnp-3806	4562	33	interest	interest	NOUN
fnp-3806	4562	34	area	area	NOUN
fnp-3806	4562	35	working	work	VERB
fnp-3806	4562	36	groups	group	NOUN
fnp-3806	4562	37	.	.	PUNCT
fnp-3806	4563	1	bmc	bmc	PROPN
fnp-3806	4563	2	med	med	PROPN
fnp-3806	4563	3	2019;17:47	2019;17:47	NUM
fnp-3806	4563	4	.	.	PUNCT
fnp-3806	4564	1	https://doi.org/10.1186/s12916-019-1283-z	https://doi.org/10.1186/s12916-019-1283-z	PROPN
fnp-3806	4564	2	frade	frade	PROPN
fnp-3806	4564	3	jm	jm	PROPN
fnp-3806	4564	4	,	,	PUNCT
fnp-3806	4564	5	ovejero	ovejero	ADJ
fnp-3806	4564	6	-	-	PUNCT
fnp-3806	4564	7	benito	benito	PROPN
fnp-3806	4564	8	mc	mc	PROPN
fnp-3806	4564	9	.	.	PROPN
fnp-3806	4564	10	neuronal	neuronal	ADJ
fnp-3806	4564	11	cell	cell	NOUN
fnp-3806	4564	12	cycle	cycle	NOUN
fnp-3806	4564	13	:	:	PUNCT
fnp-3806	4564	14	the	the	DET
fnp-3806	4564	15	neuron	neuron	NOUN
fnp-3806	4564	16	itself	itself	PRON
fnp-3806	4564	17	and	and	CCONJ
fnp-3806	4564	18	its	its	PRON
fnp-3806	4564	19	circumstances	circumstance	NOUN
fnp-3806	4564	20	.	.	PUNCT
fnp-3806	4565	1	cell	cell	NOUN
fnp-3806	4565	2	cycle	cycle	NOUN
fnp-3806	4565	3	2015;14:712	2015;14:712	NOUN
fnp-3806	4565	4	-	-	SYM
fnp-3806	4565	5	720	720	NUM
fnp-3806	4565	6	.	.	PUNCT
fnp-3806	4566	1	https://doi.org/10.1080/15384101.2015.1004937	https://doi.org/10.1080/15384101.2015.1004937	PROPN
fnp-3806	4566	2	arendt	arendt	PROPN
fnp-3806	4566	3	t	t	PROPN
fnp-3806	4566	4	,	,	PUNCT
fnp-3806	4566	5	rödel	rödel	PROPN
fnp-3806	4566	6	l	l	NOUN
fnp-3806	4566	7	,	,	PUNCT
fnp-3806	4566	8	gärtner	gärtner	PROPN
fnp-3806	4566	9	u	u	NOUN
fnp-3806	4566	10	,	,	PUNCT
fnp-3806	4566	11	et	et	PROPN
fnp-3806	4566	12	al	al	PROPN
fnp-3806	4566	13	.	.	PUNCT
fnp-3806	4567	1	expression	expression	NOUN
fnp-3806	4567	2	of	of	ADP
fnp-3806	4567	3	the	the	DET
fnp-3806	4567	4	cyclin	cyclin	NOUN
fnp-3806	4567	5	-	-	PUNCT
fnp-3806	4567	6	dependent	dependent	ADJ
fnp-3806	4567	7	kinase	kinase	NOUN
fnp-3806	4567	8	inhibitor	inhibitor	PROPN
fnp-3806	4567	9	p16	p16	PROPN
fnp-3806	4567	10	in	in	ADP
fnp-3806	4567	11	alzheimer	alzheimer	PROPN
fnp-3806	4567	12	's	's	PART
fnp-3806	4567	13	disease	disease	NOUN
fnp-3806	4567	14	.	.	PUNCT
fnp-3806	4568	1	neuroreport	neuroreport	NOUN
fnp-3806	4568	2	1996;7:3047	1996;7:3047	NUM
fnp-3806	4568	3	-	-	SYM
fnp-3806	4568	4	3049	3049	NUM
fnp-3806	4568	5	.	.	PUNCT
fnp-3806	4569	1	https://doi.org/10.1097/00001756-199611250-00050	https://doi.org/10.1097/00001756-199611250-00050	PROPN
fnp-3806	4569	2	mcshea	mcshea	PROPN
fnp-3806	4569	3	a	a	PRON
fnp-3806	4569	4	,	,	PUNCT
fnp-3806	4569	5	harris	harris	PROPN
fnp-3806	4569	6	pl	pl	PROPN
fnp-3806	4569	7	,	,	PUNCT
fnp-3806	4569	8	webster	webster	PROPN
fnp-3806	4569	9	kr	kr	PROPN
fnp-3806	4569	10	,	,	PUNCT
fnp-3806	4569	11	et	et	PROPN
fnp-3806	4569	12	al	al	PROPN
fnp-3806	4569	13	.	.	PROPN
fnp-3806	4569	14	abnormal	abnormal	ADJ
fnp-3806	4569	15	expression	expression	NOUN
fnp-3806	4569	16	of	of	ADP
fnp-3806	4569	17	the	the	DET
fnp-3806	4569	18	cell	cell	NOUN
fnp-3806	4569	19	cycle	cycle	NOUN
fnp-3806	4569	20	regulators	regulator	NOUN
fnp-3806	4569	21	p16	p16	NOUN
fnp-3806	4569	22	and	and	CCONJ
fnp-3806	4569	23	cdk4	cdk4	NOUN
fnp-3806	4569	24	in	in	ADP
fnp-3806	4569	25	alzheimer	alzheimer	PROPN
fnp-3806	4569	26	's	's	PART
fnp-3806	4569	27	disease	disease	NOUN
fnp-3806	4569	28	.	.	PUNCT
fnp-3806	4570	1	am	be	AUX
fnp-3806	4570	2	j	j	PROPN
fnp-3806	4570	3	pathol	pathol	NOUN
fnp-3806	4570	4	1997;150:1933	1997;150:1933	NUM
fnp-3806	4570	5	-	-	SYM
fnp-3806	4570	6	1939	1939	NUM
fnp-3806	4570	7	.	.	PUNCT
fnp-3806	4571	1	pmid	pmid	NOUN
fnp-3806	4571	2	:	:	PUNCT
fnp-3806	4571	3	9176387	9176387	NUM
fnp-3806	4571	4	.	.	PUNCT
fnp-3806	4572	1	nagy	nagy	PROPN
fnp-3806	4572	2	z	z	PROPN
fnp-3806	4572	3	,	,	PUNCT
fnp-3806	4572	4	esiri	esiri	PROPN
fnp-3806	4572	5	mm	mm	PROPN
fnp-3806	4572	6	,	,	PUNCT
fnp-3806	4572	7	cato	cato	PROPN
fnp-3806	4572	8	am	am	PROPN
fnp-3806	4572	9	,	,	PUNCT
fnp-3806	4572	10	et	et	PROPN
fnp-3806	4572	11	al	al	PROPN
fnp-3806	4572	12	.	.	PROPN
fnp-3806	4572	13	cell	cell	NOUN
fnp-3806	4572	14	cycle	cycle	NOUN
fnp-3806	4572	15	markers	marker	NOUN
fnp-3806	4572	16	in	in	ADP
fnp-3806	4572	17	the	the	DET
fnp-3806	4572	18	hippocampus	hippocampus	NOUN
fnp-3806	4572	19	in	in	ADP
fnp-3806	4572	20	alzheimer	alzheimer	PROPN
fnp-3806	4572	21	's	's	PART
fnp-3806	4572	22	disease	disease	NOUN
fnp-3806	4572	23	.	.	PUNCT
fnp-3806	4573	1	acta	acta	PROPN
fnp-3806	4573	2	neuropathol	neuropathol	PROPN
fnp-3806	4573	3	1997;94:6	1997;94:6	NUM
fnp-3806	4573	4	-	-	SYM
fnp-3806	4573	5	15	15	NUM
fnp-3806	4573	6	.	.	PUNCT
fnp-3806	4574	1	https://doi.org/10.1007/s004010050665	https://doi.org/10.1007/s004010050665	NUM
fnp-3806	4574	2	smith	smith	PROPN
fnp-3806	4574	3	mz	mz	PROPN
fnp-3806	4574	4	,	,	PUNCT
fnp-3806	4574	5	nagy	nagy	PROPN
fnp-3806	4574	6	z	z	PROPN
fnp-3806	4574	7	,	,	PUNCT
fnp-3806	4574	8	esiri	esiri	PROPN
fnp-3806	4574	9	mm	mm	INTJ
fnp-3806	4574	10	.	.	PUNCT
fnp-3806	4574	11	cell	cell	NOUN
fnp-3806	4574	12	cycle	cycle	NOUN
fnp-3806	4574	13	-	-	PUNCT
fnp-3806	4574	14	related	relate	VERB
fnp-3806	4574	15	protein	protein	NOUN
fnp-3806	4574	16	expression	expression	NOUN
fnp-3806	4574	17	in	in	ADP
fnp-3806	4574	18	vascular	vascular	ADJ
fnp-3806	4574	19	dementia	dementia	NOUN
fnp-3806	4574	20	and	and	CCONJ
fnp-3806	4574	21	alzheimer	alzheimer	PROPN
fnp-3806	4574	22	's	's	PART
fnp-3806	4574	23	disease	disease	NOUN
fnp-3806	4574	24	.	.	PUNCT
fnp-3806	4575	1	neurosci	neurosci	PROPN
fnp-3806	4575	2	lett	lett	PROPN
fnp-3806	4575	3	1999;271:45	1999;271:45	PROPN
fnp-3806	4575	4	-	-	SYM
fnp-3806	4575	5	48	48	NUM
fnp-3806	4575	6	.	.	PUNCT
fnp-3806	4576	1	https://doi.org/10.1016/s0304-3940(99)00509-1	https://doi.org/10.1016/s0304-3940(99)00509-1	PROPN
fnp-3806	4576	2	arendt	arendt	PROPN
fnp-3806	4576	3	t	t	PROPN
fnp-3806	4576	4	,	,	PUNCT
fnp-3806	4576	5	holzer	holzer	PROPN
fnp-3806	4576	6	m	m	PROPN
fnp-3806	4576	7	,	,	PUNCT
fnp-3806	4576	8	gärtner	gärtner	PROPN
fnp-3806	4576	9	u.	u.	NOUN
fnp-3806	4576	10	neuronal	neuronal	ADJ
fnp-3806	4576	11	expression	expression	NOUN
fnp-3806	4576	12	of	of	ADP
fnp-3806	4576	13	cycline	cycline	PROPN
fnp-3806	4576	14	dependent	dependent	ADJ
fnp-3806	4576	15	kinase	kinase	PROPN
fnp-3806	4576	16	inhibitors	inhibitor	NOUN
fnp-3806	4576	17	of	of	ADP
fnp-3806	4576	18	the	the	DET
fnp-3806	4576	19	ink4	ink4	PROPN
fnp-3806	4576	20	family	family	PROPN
fnp-3806	4576	21	in	in	ADP
fnp-3806	4576	22	alzheimer	alzheimer	PROPN
fnp-3806	4576	23	's	's	PART
fnp-3806	4576	24	disease	disease	NOUN
fnp-3806	4576	25	.	.	PUNCT
fnp-3806	4577	1	j	j	PROPN
fnp-3806	4577	2	neural	neural	ADJ
fnp-3806	4577	3	transm	transm	PROPN
fnp-3806	4577	4	1998;105:949	1998;105:949	NUM
fnp-3806	4577	5	-	-	SYM
fnp-3806	4577	6	960	960	NUM
fnp-3806	4577	7	.	.	PUNCT
fnp-3806	4578	1	https://doi.org/10.1007/s007020050104	https://doi.org/10.1007/s007020050104	PROPN
fnp-3806	4578	2	raina	raina	PROPN
fnp-3806	4578	3	ak	ak	PROPN
fnp-3806	4578	4	,	,	PUNCT
fnp-3806	4578	5	zhu	zhu	PROPN
fnp-3806	4578	6	x	x	SYM
fnp-3806	4578	7	,	,	PUNCT
fnp-3806	4578	8	rottkamp	rottkamp	PROPN
fnp-3806	4578	9	ca	ca	NOUN
fnp-3806	4578	10	,	,	PUNCT
fnp-3806	4578	11	et	et	PROPN
fnp-3806	4578	12	al	al	PROPN
fnp-3806	4578	13	.	.	PROPN
fnp-3806	4578	14	cyclin	cyclin	PROPN
fnp-3806	4578	15	toward	toward	ADP
fnp-3806	4578	16	dementia	dementia	NOUN
fnp-3806	4578	17	:	:	PUNCT
fnp-3806	4578	18	cell	cell	NOUN
fnp-3806	4578	19	cycle	cycle	NOUN
fnp-3806	4578	20	abnormalities	abnormality	NOUN
fnp-3806	4578	21	and	and	CCONJ
fnp-3806	4578	22	abortive	abortive	ADJ
fnp-3806	4578	23	oncogenesis	oncogenesis	NOUN
fnp-3806	4578	24	in	in	ADP
fnp-3806	4578	25	alzheimer	alzheimer	PROPN
fnp-3806	4578	26	disease	disease	NOUN
fnp-3806	4578	27	.	.	PUNCT
fnp-3806	4579	1	j	j	PROPN
fnp-3806	4579	2	neurosci	neurosci	PROPN
fnp-3806	4579	3	res	re	VERB
fnp-3806	4579	4	2000;61:128	2000;61:128	PROPN
fnp-3806	4579	5	-	-	SYM
fnp-3806	4579	6	133	133	NUM
fnp-3806	4579	7	.	.	PUNCT
fnp-3806	4580	1	https://doi.org/10.1002/1097-4547(20000715)61:2<128::aid-jnr2>3.0.co;2-h	https://doi.org/10.1002/1097-4547(20000715)61:2<128::aid-jnr2>3.0.co;2-h	PROPN
fnp-3806	4580	2	arendt	arendt	PROPN
fnp-3806	4580	3	t.	t.	PROPN
fnp-3806	4580	4	alzheimer	alzheimer	PROPN
fnp-3806	4580	5	's	's	PART
fnp-3806	4580	6	disease	disease	NOUN
fnp-3806	4580	7	as	as	ADP
fnp-3806	4580	8	a	a	DET
fnp-3806	4580	9	loss	loss	NOUN
fnp-3806	4580	10	of	of	ADP
fnp-3806	4580	11	differentiation	differentiation	NOUN
fnp-3806	4580	12	control	control	NOUN
fnp-3806	4580	13	in	in	ADP
fnp-3806	4580	14	a	a	DET
fnp-3806	4580	15	subset	subset	NOUN
fnp-3806	4580	16	of	of	ADP
fnp-3806	4580	17	neurons	neuron	NOUN
fnp-3806	4580	18	that	that	PRON
fnp-3806	4580	19	retain	retain	VERB
fnp-3806	4580	20	immature	immature	ADJ
fnp-3806	4580	21	features	feature	NOUN
fnp-3806	4580	22	in	in	ADP
fnp-3806	4580	23	the	the	DET
fnp-3806	4580	24	adult	adult	NOUN
fnp-3806	4580	25	brain	brain	NOUN
fnp-3806	4580	26	.	.	PUNCT
fnp-3806	4581	1	neurobiol	neurobiol	PROPN
fnp-3806	4581	2	aging	age	VERB
fnp-3806	4581	3	2000;21:783	2000;21:783	NOUN
fnp-3806	4581	4	-	-	SYM
fnp-3806	4581	5	796	796	NUM
fnp-3806	4581	6	.	.	PUNCT
fnp-3806	4582	1	https://doi.org/10.1016/s0197-4580(00)00216-5	https://doi.org/10.1016/s0197-4580(00)00216-5	PROPN
fnp-3806	4582	2	ueberham	ueberham	PROPN
fnp-3806	4582	3	u	u	PROPN
fnp-3806	4582	4	,	,	PUNCT
fnp-3806	4582	5	arendt	arendt	PROPN
fnp-3806	4582	6	t.	t.	PROPN
fnp-3806	4582	7	the	the	DET
fnp-3806	4582	8	expression	expression	NOUN
fnp-3806	4582	9	of	of	ADP
fnp-3806	4582	10	cell	cell	NOUN
fnp-3806	4582	11	cycle	cycle	NOUN
fnp-3806	4582	12	proteins	protein	NOUN
fnp-3806	4582	13	in	in	ADP
fnp-3806	4582	14	neurons	neuron	NOUN
fnp-3806	4582	15	and	and	CCONJ
fnp-3806	4582	16	its	its	PRON
fnp-3806	4582	17	relevance	relevance	NOUN
fnp-3806	4582	18	for	for	ADP
fnp-3806	4582	19	alzheimer	alzheimer	PROPN
fnp-3806	4582	20	's	's	PART
fnp-3806	4582	21	disease	disease	NOUN
fnp-3806	4582	22	.	.	PUNCT
fnp-3806	4583	1	curr	curr	PROPN
fnp-3806	4583	2	drug	drug	NOUN
fnp-3806	4583	3	targets	target	NOUN
fnp-3806	4583	4	cns	cns	PROPN
fnp-3806	4583	5	neurol	neurol	PROPN
fnp-3806	4583	6	disord	disord	PROPN
fnp-3806	4583	7	2005;4:293	2005;4:293	NOUN
fnp-3806	4583	8	-	-	SYM
fnp-3806	4583	9	306	306	NUM
fnp-3806	4583	10	.	.	PUNCT
fnp-3806	4584	1	https://doi.org/10.2174/1568007054038175	https://doi.org/10.2174/1568007054038175	PROPN
fnp-3806	4584	2	lee	lee	PROPN
fnp-3806	4584	3	hg	hg	PROPN
fnp-3806	4584	4	,	,	PUNCT
fnp-3806	4584	5	casadesus	casadesus	PROPN
fnp-3806	4584	6	g	g	PROPN
fnp-3806	4584	7	,	,	PUNCT
fnp-3806	4584	8	zhu	zhu	PROPN
fnp-3806	4584	9	x	x	X
fnp-3806	4584	10	,	,	PUNCT
fnp-3806	4584	11	et	et	PROPN
fnp-3806	4584	12	al	al	PROPN
fnp-3806	4584	13	.	.	PROPN
fnp-3806	4584	14	cell	cell	PROPN
fnp-3806	4584	15	cycle	cycle	NOUN
fnp-3806	4584	16	re	re	NOUN
fnp-3806	4584	17	-	-	NOUN
fnp-3806	4584	18	entry	entry	NOUN
fnp-3806	4584	19	mediated	mediate	VERB
fnp-3806	4584	20	neurodegeneration	neurodegeneration	NOUN
fnp-3806	4584	21	and	and	CCONJ
fnp-3806	4584	22	its	its	PRON
fnp-3806	4584	23	treatment	treatment	NOUN
fnp-3806	4584	24	role	role	NOUN
fnp-3806	4584	25	in	in	ADP
fnp-3806	4584	26	the	the	DET
fnp-3806	4584	27	pathogenesis	pathogenesis	NOUN
fnp-3806	4584	28	of	of	ADP
fnp-3806	4584	29	alzheimer	alzheimer	PROPN
fnp-3806	4584	30	's	's	PART
fnp-3806	4584	31	disease	disease	NOUN
fnp-3806	4584	32	.	.	PUNCT
fnp-3806	4585	1	neurochem	neurochem	PROPN
fnp-3806	4585	2	int	int	VERB
fnp-3806	4585	3	2009;54:84	2009;54:84	NOUN
fnp-3806	4585	4	-	-	SYM
fnp-3806	4585	5	88	88	NUM
fnp-3806	4585	6	.	.	PUNCT
fnp-3806	4586	1	https://doi.org/10.1016/j.neuint.2008.10.013	https://doi.org/10.1016/j.neuint.2008.10.013	VERB
fnp-3806	4586	2	moh	moh	PROPN
fnp-3806	4586	3	c	c	NOUN
fnp-3806	4586	4	,	,	PUNCT
fnp-3806	4586	5	kubiak	kubiak	PROPN
fnp-3806	4586	6	jz	jz	PROPN
fnp-3806	4586	7	,	,	PUNCT
fnp-3806	4586	8	bajic	bajic	PROPN
fnp-3806	4586	9	vp	vp	PROPN
fnp-3806	4586	10	,	,	PUNCT
fnp-3806	4586	11	et	et	PROPN
fnp-3806	4586	12	al	al	PROPN
fnp-3806	4586	13	.	.	PROPN
fnp-3806	4586	14	cell	cell	NOUN
fnp-3806	4586	15	cycle	cycle	NOUN
fnp-3806	4586	16	deregulation	deregulation	NOUN
fnp-3806	4586	17	in	in	ADP
fnp-3806	4586	18	the	the	DET
fnp-3806	4586	19	neurons	neuron	NOUN
fnp-3806	4586	20	of	of	ADP
fnp-3806	4586	21	alzheimer	alzheimer	PROPN
fnp-3806	4586	22	's	's	PART
fnp-3806	4586	23	disease	disease	NOUN
fnp-3806	4586	24	.	.	PUNCT
fnp-3806	4587	1	results	result	NOUN
fnp-3806	4587	2	probl	probl	NOUN
fnp-3806	4587	3	cell	cell	NOUN
fnp-3806	4587	4	differ	differ	VERB
fnp-3806	4587	5	2011;53:565	2011;53:565	PROPN
fnp-3806	4587	6	-	-	SYM
fnp-3806	4587	7	576	576	NUM
fnp-3806	4587	8	.	.	PUNCT
fnp-3806	4588	1	https://doi.org/10.1007/978-3-642-19065-0_23	https://doi.org/10.1007/978-3-642-19065-0_23	PRON
fnp-3806	4588	2	koseoglu	koseoglu	PROPN
fnp-3806	4588	3	mm	mm	PROPN
fnp-3806	4588	4	,	,	PUNCT
fnp-3806	4588	5	norambuena	norambuena	PROPN
fnp-3806	4588	6	a	a	PRON
fnp-3806	4588	7	,	,	PUNCT
fnp-3806	4588	8	sharlow	sharlow	NOUN
fnp-3806	4588	9	er	er	INTJ
fnp-3806	4588	10	,	,	PUNCT
fnp-3806	4588	11	et	et	PROPN
fnp-3806	4588	12	al	al	PROPN
fnp-3806	4588	13	.	.	PROPN
fnp-3806	4588	14	aberrant	aberrant	ADJ
fnp-3806	4588	15	neuronal	neuronal	ADJ
fnp-3806	4588	16	cell	cell	NOUN
fnp-3806	4588	17	cycle	cycle	NOUN
fnp-3806	4588	18	re	re	NOUN
fnp-3806	4588	19	-	-	NOUN
fnp-3806	4588	20	entry	entry	NOUN
fnp-3806	4588	21	:	:	PUNCT
fnp-3806	4588	22	the	the	DET
fnp-3806	4588	23	pathological	pathological	ADJ
fnp-3806	4588	24	confluence	confluence	NOUN
fnp-3806	4588	25	of	of	ADP
fnp-3806	4588	26	alzheimer	alzheimer	PROPN
fnp-3806	4588	27	's	's	PART
fnp-3806	4588	28	disease	disease	NOUN
fnp-3806	4588	29	and	and	CCONJ
fnp-3806	4588	30	brain	brain	NOUN
fnp-3806	4588	31	insulin	insulin	NOUN
fnp-3806	4588	32	resistance	resistance	NOUN
fnp-3806	4588	33	,	,	PUNCT
fnp-3806	4588	34	and	and	CCONJ
fnp-3806	4588	35	its	its	PRON
fnp-3806	4588	36	relation	relation	NOUN
fnp-3806	4588	37	to	to	ADP
fnp-3806	4588	38	cancer	cancer	NOUN
fnp-3806	4588	39	.	.	PUNCT
fnp-3806	4589	1	j	j	PROPN
fnp-3806	4589	2	alzheimers	alzheimers	PROPN
fnp-3806	4589	3	dis	dis	PROPN
fnp-3806	4589	4	2019;67:1	2019;67:1	NUM
fnp-3806	4589	5	-	-	SYM
fnp-3806	4589	6	11	11	NUM
fnp-3806	4589	7	.	.	PUNCT
fnp-3806	4590	1	https://doi.org/10.3233/jad-180874	https://doi.org/10.3233/jad-180874	PROPN
fnp-3806	4590	2	mcshea	mcshea	PROPN
fnp-3806	4590	3	a	a	PRON
fnp-3806	4590	4	,	,	PUNCT
fnp-3806	4590	5	wahl	wahl	PROPN
fnp-3806	4590	6	af	af	PROPN
fnp-3806	4590	7	,	,	PUNCT
fnp-3806	4590	8	smith	smith	PROPN
fnp-3806	4590	9	ma	ma	PROPN
fnp-3806	4590	10	.	.	PROPN
fnp-3806	4590	11	re	re	PROPN
fnp-3806	4590	12	-	-	NOUN
fnp-3806	4590	13	entry	entry	NOUN
fnp-3806	4590	14	into	into	ADP
fnp-3806	4590	15	the	the	DET
fnp-3806	4590	16	cell	cell	NOUN
fnp-3806	4590	17	cycle	cycle	NOUN
fnp-3806	4590	18	:	:	PUNCT
fnp-3806	4590	19	a	a	DET
fnp-3806	4590	20	mechanism	mechanism	NOUN
fnp-3806	4590	21	for	for	ADP
fnp-3806	4590	22	neurodegeneration	neurodegeneration	NOUN
fnp-3806	4590	23	in	in	ADP
fnp-3806	4590	24	alzheimer	alzheimer	PROPN
fnp-3806	4590	25	disease	disease	PROPN
fnp-3806	4590	26	.	.	PUNCT
fnp-3806	4591	1	med	med	ADJ
fnp-3806	4591	2	hypotheses	hypothesis	NOUN
fnp-3806	4591	3	1999;52:525	1999;52:525	PROPN
fnp-3806	4591	4	-	-	SYM
fnp-3806	4591	5	527	527	NUM
fnp-3806	4591	6	.	.	PUNCT
fnp-3806	4592	1	https://doi.org/10.1054/mehy.1997.0680	https://doi.org/10.1054/mehy.1997.0680	PROPN
fnp-3806	4592	2	nagy	nagy	PROPN
fnp-3806	4592	3	z.	z.	PROPN
fnp-3806	4592	4	cell	cell	PROPN
fnp-3806	4592	5	cycle	cycle	NOUN
fnp-3806	4592	6	regulatory	regulatory	ADJ
fnp-3806	4592	7	failure	failure	NOUN
fnp-3806	4592	8	in	in	ADP
fnp-3806	4592	9	neurones	neurone	NOUN
fnp-3806	4592	10	:	:	PUNCT
fnp-3806	4592	11	causes	cause	NOUN
fnp-3806	4592	12	and	and	CCONJ
fnp-3806	4592	13	consequences	consequence	NOUN
fnp-3806	4592	14	.	.	PUNCT
fnp-3806	4593	1	neurobiol	neurobiol	ADJ
fnp-3806	4593	2	aging	age	VERB
fnp-3806	4593	3	2000;21:761	2000;21:761	PROPN
fnp-3806	4593	4	-	-	SYM
fnp-3806	4593	5	769	769	NUM
fnp-3806	4593	6	.	.	PUNCT
fnp-3806	4594	1	https://doi.org/10.1016/s0197-4580(00)00223-2	https://doi.org/10.1016/s0197-4580(00)00223-2	PROPN
fnp-3806	4594	2	arendt	arendt	PROPN
fnp-3806	4594	3	t.	t.	PROPN
fnp-3806	4594	4	alzheimer	alzheimer	PROPN
fnp-3806	4594	5	's	's	PART
fnp-3806	4594	6	disease	disease	NOUN
fnp-3806	4594	7	as	as	ADP
fnp-3806	4594	8	a	a	DET
fnp-3806	4594	9	disorder	disorder	NOUN
fnp-3806	4594	10	of	of	ADP
fnp-3806	4594	11	mechanisms	mechanism	NOUN
fnp-3806	4594	12	underlying	underlie	VERB
fnp-3806	4594	13	structural	structural	ADJ
fnp-3806	4594	14	brain	brain	NOUN
fnp-3806	4594	15	self	self	NOUN
fnp-3806	4594	16	-	-	PUNCT
fnp-3806	4594	17	organization	organization	NOUN
fnp-3806	4594	18	.	.	PUNCT
fnp-3806	4595	1	neuroscience	neuroscience	NOUN
fnp-3806	4595	2	2001;102:723	2001;102:723	NUM
fnp-3806	4595	3	-	-	SYM
fnp-3806	4595	4	765	765	NUM
fnp-3806	4595	5	.	.	PUNCT
fnp-3806	4595	6	https://doi.org/10.1016/s0306-4522(00)00516-9	https://doi.org/10.1016/s0306-4522(00)00516-9	PROPN
fnp-3806	4595	7	lopes	lopes	PROPN
fnp-3806	4595	8	jp	jp	PROPN
fnp-3806	4595	9	,	,	PUNCT
fnp-3806	4595	10	oliveira	oliveira	PROPN
fnp-3806	4595	11	cr	cr	PROPN
fnp-3806	4595	12	,	,	PUNCT
fnp-3806	4595	13	agostinho	agostinho	PROPN
fnp-3806	4595	14	p.	p.	NOUN
fnp-3806	4595	15	cell	cell	NOUN
fnp-3806	4595	16	cycle	cycle	NOUN
fnp-3806	4595	17	re	re	NOUN
fnp-3806	4595	18	-	-	NOUN
fnp-3806	4595	19	entry	entry	NOUN
fnp-3806	4595	20	in	in	ADP
fnp-3806	4595	21	alzheimer	alzheimer	PROPN
fnp-3806	4595	22	's	's	PART
fnp-3806	4595	23	disease	disease	NOUN
fnp-3806	4595	24	:	:	PUNCT
fnp-3806	4595	25	a	a	DET
fnp-3806	4595	26	major	major	ADJ
fnp-3806	4595	27	neuropathological	neuropathological	ADJ
fnp-3806	4595	28	characteristic	characteristic	NOUN
fnp-3806	4595	29	?	?	PUNCT
fnp-3806	4596	1	curr	curr	PROPN
fnp-3806	4596	2	alzheimer	alzheimer	PROPN
fnp-3806	4596	3	res	res	PROPN
fnp-3806	4596	4	2009;6:205	2009;6:205	NOUN
fnp-3806	4596	5	-	-	NUM
fnp-3806	4596	6	212	212	NUM
fnp-3806	4596	7	.	.	PUNCT
fnp-3806	4597	1	https://doi.org/10.2174/156720509788486590	https://doi.org/10.2174/156720509788486590	ADP
fnp-3806	4597	2	bonda	bonda	PROPN
fnp-3806	4597	3	dj	dj	PROPN
fnp-3806	4597	4	,	,	PUNCT
fnp-3806	4597	5	lee	lee	PROPN
fnp-3806	4597	6	hp	hp	PROPN
fnp-3806	4597	7	,	,	PUNCT
fnp-3806	4597	8	kudo	kudo	PROPN
fnp-3806	4597	9	w	w	PROPN
fnp-3806	4597	10	,	,	PUNCT
fnp-3806	4597	11	et	et	PROPN
fnp-3806	4597	12	al	al	PROPN
fnp-3806	4597	13	.	.	PUNCT
fnp-3806	4598	1	pathological	pathological	ADJ
fnp-3806	4598	2	implications	implication	NOUN
fnp-3806	4598	3	of	of	ADP
fnp-3806	4598	4	cell	cell	NOUN
fnp-3806	4598	5	cycle	cycle	NOUN
fnp-3806	4598	6	re	re	NOUN
fnp-3806	4598	7	-	-	NOUN
fnp-3806	4598	8	entry	entry	NOUN
fnp-3806	4598	9	in	in	ADP
fnp-3806	4598	10	alzheimer	alzheimer	PROPN
fnp-3806	4598	11	disease	disease	NOUN
fnp-3806	4598	12	.	.	PUNCT
fnp-3806	4599	1	expert	expert	PROPN
fnp-3806	4599	2	rev	rev	PROPN
fnp-3806	4599	3	mol	mol	ADP
fnp-3806	4599	4	med	med	PROPN
fnp-3806	4599	5	2010;12	2010;12	NOUN
fnp-3806	4599	6	:	:	PUNCT
fnp-3806	4599	7	e19	e19	VERB
fnp-3806	4599	8	.	.	PUNCT
fnp-3806	4600	1	https://doi.org/10.1017/s146239941000150x	https://doi.org/10.1017/s146239941000150x	PROPN
fnp-3806	4600	2	barrio	barrio	PROPN
fnp-3806	4600	3	-	-	PUNCT
fnp-3806	4600	4	alonso	alonso	PROPN
fnp-3806	4600	5	e	e	NOUN
fnp-3806	4600	6	,	,	PUNCT
fnp-3806	4600	7	hernández	hernández	PROPN
fnp-3806	4600	8	-	-	PUNCT
fnp-3806	4600	9	vivanco	vivanco	PROPN
fnp-3806	4600	10	a	a	PROPN
fnp-3806	4600	11	,	,	PUNCT
fnp-3806	4600	12	walton	walton	PROPN
fnp-3806	4600	13	cc	cc	PROPN
fnp-3806	4600	14	,	,	PUNCT
fnp-3806	4600	15	et	et	PROPN
fnp-3806	4600	16	al	al	PROPN
fnp-3806	4600	17	.	.	PROPN
fnp-3806	4600	18	cell	cell	NOUN
fnp-3806	4600	19	cycle	cycle	NOUN
fnp-3806	4600	20	reentry	reentry	NOUN
fnp-3806	4600	21	triggers	trigger	VERB
fnp-3806	4600	22	hyperploidization	hyperploidization	NOUN
fnp-3806	4600	23	and	and	CCONJ
fnp-3806	4600	24	synaptic	synaptic	ADJ
fnp-3806	4600	25	dysfunction	dysfunction	NOUN
fnp-3806	4600	26	followed	follow	VERB
fnp-3806	4600	27	by	by	ADP
fnp-3806	4600	28	delayed	delay	VERB
fnp-3806	4600	29	cell	cell	NOUN
fnp-3806	4600	30	death	death	NOUN
fnp-3806	4600	31	in	in	ADP
fnp-3806	4600	32	differentiated	differentiate	VERB
fnp-3806	4600	33	cortical	cortical	ADJ
fnp-3806	4600	34	neurons	neuron	NOUN
fnp-3806	4600	35	.	.	PUNCT
fnp-3806	4601	1	sci	sci	PROPN
fnp-3806	4601	2	rep	rep	PROPN
fnp-3806	4601	3	2018;8:14316	2018;8:14316	PROPN
fnp-3806	4601	4	.	.	PUNCT
fnp-3806	4602	1	https://doi.org/10.1038/s41598-018-32708-4	https://doi.org/10.1038/s41598-018-32708-4	NUM
fnp-3806	4602	2	olabiyi	olabiyi	PROPN
fnp-3806	4602	3	bf	bf	NOUN
fnp-3806	4602	4	,	,	PUNCT
fnp-3806	4602	5	fleitas	fleita	NOUN
fnp-3806	4602	6	c	c	NOUN
fnp-3806	4602	7	,	,	PUNCT
fnp-3806	4602	8	zammou	zammou	NOUN
fnp-3806	4602	9	b	b	PROPN
fnp-3806	4602	10	et	et	PROPN
fnp-3806	4602	11	al	al	PROPN
fnp-3806	4602	12	.	.	PROPN
fnp-3806	4602	13	prongf	prongf	PROPN
fnp-3806	4602	14	involvement	involvement	NOUN
fnp-3806	4602	15	in	in	ADP
fnp-3806	4602	16	the	the	DET
fnp-3806	4602	17	adult	adult	NOUN
fnp-3806	4602	18	neurogenesis	neurogenesis	NOUN
fnp-3806	4602	19	dysfunction	dysfunction	NOUN
fnp-3806	4602	20	in	in	ADP
fnp-3806	4602	21	alzheimer	alzheimer	PROPN
fnp-3806	4602	22	's	's	PART
fnp-3806	4602	23	disease	disease	NOUN
fnp-3806	4602	24	.	.	PUNCT
fnp-3806	4603	1	int	int	PROPN
fnp-3806	4603	2	j	j	PROPN
fnp-3806	4603	3	mol	mol	ADP
fnp-3806	4603	4	sci	sci	PROPN
fnp-3806	4603	5	2021;22:10744	2021;22:10744	NUM
fnp-3806	4603	6	.	.	PUNCT
fnp-3806	4604	1	https://doi.org/10.3390/ijms221910744	https://doi.org/10.3390/ijms221910744	NOUN
fnp-3806	4604	2	terreros	terrero	NOUN
fnp-3806	4604	3	-	-	PUNCT
fnp-3806	4604	4	roncal	roncal	PROPN
fnp-3806	4604	5	j	j	PROPN
fnp-3806	4604	6	,	,	PUNCT
fnp-3806	4604	7	moreno	moreno	PROPN
fnp-3806	4604	8	-	-	PUNCT
fnp-3806	4604	9	jiménez	jiménez	PROPN
fnp-3806	4604	10	ep	ep	PROPN
fnp-3806	4604	11	,	,	PUNCT
fnp-3806	4604	12	flor	flor	NOUN
fnp-3806	4604	13	-	-	PUNCT
fnp-3806	4604	14	garcía	garcía	PROPN
fnp-3806	4604	15	m	m	PROPN
fnp-3806	4604	16	,	,	PUNCT
fnp-3806	4604	17	et	et	PROPN
fnp-3806	4604	18	al	al	PROPN
fnp-3806	4604	19	.	.	PROPN
fnp-3806	4604	20	impact	impact	NOUN
fnp-3806	4604	21	of	of	ADP
fnp-3806	4604	22	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4604	23	diseases	disease	NOUN
fnp-3806	4604	24	on	on	ADP
fnp-3806	4604	25	human	human	ADJ
fnp-3806	4604	26	adult	adult	NOUN
fnp-3806	4604	27	hippocampal	hippocampal	ADJ
fnp-3806	4604	28	neurogenesis	neurogenesis	NOUN
fnp-3806	4604	29	.	.	PUNCT
fnp-3806	4605	1	science	science	NOUN
fnp-3806	4605	2	2021;374:1106	2021;374:1106	NUM
fnp-3806	4605	3	-	-	SYM
fnp-3806	4605	4	1113	1113	NUM
fnp-3806	4605	5	.	.	PUNCT
fnp-3806	4606	1	https://doi.org/10.1126/science.abl516	https://doi.org/10.1126/science.abl516	ADJ
fnp-3806	4606	2	dietschy	dietschy	ADJ
fnp-3806	4606	3	jm	jm	PROPN
fnp-3806	4606	4	,	,	PUNCT
fnp-3806	4606	5	turley	turley	PROPN
fnp-3806	4606	6	sd	sd	PROPN
fnp-3806	4606	7	.	.	PUNCT
fnp-3806	4607	1	cholesterol	cholesterol	NOUN
fnp-3806	4607	2	metabolism	metabolism	NOUN
fnp-3806	4607	3	in	in	ADP
fnp-3806	4607	4	the	the	DET
fnp-3806	4607	5	brain	brain	NOUN
fnp-3806	4607	6	.	.	PUNCT
fnp-3806	4608	1	curr	curr	PROPN
fnp-3806	4608	2	opin	opin	NOUN
fnp-3806	4608	3	lipidol	lipidol	ADJ
fnp-3806	4608	4	2001	2001	NUM
fnp-3806	4608	5	;	;	PUNCT
fnp-3806	4608	6	12	12	NUM
fnp-3806	4608	7	:	:	PUNCT
fnp-3806	4608	8	105	105	NUM
fnp-3806	4608	9	-	-	SYM
fnp-3806	4608	10	112	112	NUM
fnp-3806	4608	11	.	.	PUNCT
fnp-3806	4608	12	https://doi.org/10.1097/00041433-200104000-00003	https://doi.org/10.1097/00041433-200104000-00003	NOUN
fnp-3806	4608	13	naudí	naudí	VERB
fnp-3806	4608	14	a	a	DET
fnp-3806	4608	15	,	,	PUNCT
fnp-3806	4608	16	cabré	cabré	PROPN
fnp-3806	4608	17	r	r	NOUN
fnp-3806	4608	18	,	,	PUNCT
fnp-3806	4608	19	jové	jové	PROPN
fnp-3806	4608	20	m	m	PROPN
fnp-3806	4608	21	,	,	PUNCT
fnp-3806	4608	22	et	et	PROPN
fnp-3806	4608	23	al	al	PROPN
fnp-3806	4608	24	.	.	PROPN
fnp-3806	4608	25	lipidomics	lipidomic	NOUN
fnp-3806	4608	26	of	of	ADP
fnp-3806	4608	27	human	human	ADJ
fnp-3806	4608	28	brain	brain	NOUN
fnp-3806	4608	29	aging	aging	NOUN
fnp-3806	4608	30	and	and	CCONJ
fnp-3806	4608	31	alzheimer	alzheimer	PROPN
fnp-3806	4608	32	’s	’s	PART
fnp-3806	4608	33	disease	disease	NOUN
fnp-3806	4608	34	pathology	pathology	PROPN
fnp-3806	4608	35	.	.	PUNCT
fnp-3806	4609	1	int	int	PROPN
fnp-3806	4609	2	rev	rev	PROPN
fnp-3806	4609	3	neurobiol	neurobiol	PROPN
fnp-3806	4609	4	2015;122:133	2015;122:133	NUM
fnp-3806	4609	5	-	-	SYM
fnp-3806	4609	6	189	189	NUM
fnp-3806	4609	7	.	.	PUNCT
fnp-3806	4610	1	https://doi.org/10.1016/bs.irn.2015.05.008	https://doi.org/10.1016/bs.irn.2015.05.008	PRON
fnp-3806	4610	2	farooqui	farooqui	PROPN
fnp-3806	4610	3	aa	aa	NOUN
fnp-3806	4610	4	,	,	PUNCT
fnp-3806	4610	5	horrocks	horrock	VERB
fnp-3806	4610	6	la	la	PROPN
fnp-3806	4610	7	,	,	PUNCT
fnp-3806	4610	8	farooqui	farooqui	PROPN
fnp-3806	4610	9	t.	t.	PROPN
fnp-3806	4610	10	glycerophospholipids	glycerophospholipid	NOUN
fnp-3806	4610	11	in	in	ADP
fnp-3806	4610	12	brain	brain	NOUN
fnp-3806	4610	13	:	:	PUNCT
fnp-3806	4610	14	their	their	PRON
fnp-3806	4610	15	metabolism	metabolism	NOUN
fnp-3806	4610	16	,	,	PUNCT
fnp-3806	4610	17	incorporation	incorporation	NOUN
fnp-3806	4610	18	into	into	ADP
fnp-3806	4610	19	membranes	membrane	NOUN
fnp-3806	4610	20	,	,	PUNCT
fnp-3806	4610	21	functions	function	NOUN
fnp-3806	4610	22	,	,	PUNCT
fnp-3806	4610	23	and	and	CCONJ
fnp-3806	4610	24	involvement	involvement	NOUN
fnp-3806	4610	25	in	in	ADP
fnp-3806	4610	26	neurological	neurological	ADJ
fnp-3806	4610	27	disorders	disorder	NOUN
fnp-3806	4610	28	.	.	PUNCT
fnp-3806	4611	1	chem	chem	NOUN
fnp-3806	4611	2	phys	phy	NOUN
fnp-3806	4611	3	lipids	lipid	VERB
fnp-3806	4611	4	2000;106:1	2000;106:1	PROPN
fnp-3806	4611	5	-	-	SYM
fnp-3806	4611	6	29	29	NUM
fnp-3806	4611	7	.	.	PUNCT
fnp-3806	4612	1	https://doi.org/10.1016/s0009-3084(00)00128-6	https://doi.org/10.1016/s0009-3084(00)00128-6	PROPN
fnp-3806	4612	2	farooqui	farooqui	PROPN
fnp-3806	4613	1	aa	aa	PROPN
fnp-3806	4613	2	.	.	PUNCT
fnp-3806	4614	1	lipid	lipid	ADJ
fnp-3806	4614	2	mediators	mediator	NOUN
fnp-3806	4614	3	in	in	ADP
fnp-3806	4614	4	the	the	DET
fnp-3806	4614	5	neural	neural	ADJ
fnp-3806	4614	6	cell	cell	NOUN
fnp-3806	4614	7	nucleus	nucleus	NOUN
fnp-3806	4614	8	:	:	PUNCT
fnp-3806	4614	9	their	their	PRON
fnp-3806	4614	10	metabolism	metabolism	NOUN
fnp-3806	4614	11	,	,	PUNCT
fnp-3806	4614	12	signaling	signal	VERB
fnp-3806	4614	13	,	,	PUNCT
fnp-3806	4614	14	and	and	CCONJ
fnp-3806	4614	15	association	association	NOUN
fnp-3806	4614	16	with	with	ADP
fnp-3806	4614	17	neurological	neurological	ADJ
fnp-3806	4614	18	disorders	disorder	NOUN
fnp-3806	4614	19	.	.	PUNCT
fnp-3806	4615	1	neuroscientist	neuroscientist	NOUN
fnp-3806	4615	2	2009;15:392	2009;15:392	PROPN
fnp-3806	4615	3	-	-	SYM
fnp-3806	4615	4	407	407	NUM
fnp-3806	4615	5	.	.	PUNCT
fnp-3806	4616	1	https://doi.org/10.1177/1073858409337035	https://doi.org/10.1177/1073858409337035	PROPN
fnp-3806	4616	2	piomelli	piomelli	PROPN
fnp-3806	4616	3	d.	d.	PROPN
fnp-3806	4616	4	the	the	DET
fnp-3806	4616	5	challenge	challenge	NOUN
fnp-3806	4616	6	of	of	ADP
fnp-3806	4616	7	brain	brain	NOUN
fnp-3806	4616	8	lipidomics	lipidomic	NOUN
fnp-3806	4616	9	.	.	PUNCT
fnp-3806	4617	1	prostaglandins	prostaglandin	NOUN
fnp-3806	4617	2	lipid	lipid	NOUN
fnp-3806	4617	3	mediat	mediat	PROPN
fnp-3806	4617	4	2005;77	2005;77	NOUN
fnp-3806	4617	5	:	:	PUNCT
fnp-3806	4617	6	23	23	NUM
fnp-3806	4617	7	-	-	SYM
fnp-3806	4617	8	34	34	NUM
fnp-3806	4617	9	.	.	PUNCT
fnp-3806	4618	1	https://doi.org/10.1016/j.prostaglandins.2004.09.006	https://doi.org/10.1016/j.prostaglandins.2004.09.006	NOUN
fnp-3806	4618	2	piomelli	piomelli	NOUN
fnp-3806	4618	3	d	d	PROPN
fnp-3806	4618	4	,	,	PUNCT
fnp-3806	4618	5	astarita	astarita	PROPN
fnp-3806	4618	6	g	g	PROPN
fnp-3806	4618	7	,	,	PUNCT
fnp-3806	4618	8	rapaka	rapaka	PROPN
fnp-3806	4618	9	r.	r.	PROPN
fnp-3806	4618	10	a	a	DET
fnp-3806	4618	11	neuroscientist	neuroscientist	NOUN
fnp-3806	4618	12	's	's	PART
fnp-3806	4618	13	guide	guide	NOUN
fnp-3806	4618	14	to	to	ADP
fnp-3806	4618	15	lipidomics	lipidomic	NOUN
fnp-3806	4618	16	.	.	PUNCT
fnp-3806	4619	1	nature	nature	PROPN
fnp-3806	4619	2	rev	rev	VERB
fnp-3806	4619	3	neurosci	neurosci	PROPN
fnp-3806	4619	4	2007	2007	NUM
fnp-3806	4619	5	;	;	PUNCT
fnp-3806	4619	6	8:743	8:743	NUM
fnp-3806	4619	7	-	-	SYM
fnp-3806	4619	8	754	754	NUM
fnp-3806	4619	9	.	.	PUNCT
fnp-3806	4620	1	https://doi.org/10.1038/nrn2233	https://doi.org/10.1038/nrn2233	ADJ
fnp-3806	4620	2	pamplona	pamplona	PROPN
fnp-3806	4620	3	r	r	NOUN
fnp-3806	4620	4	,	,	PUNCT
fnp-3806	4620	5	barja	barja	NOUN
fnp-3806	4620	6	g	g	NOUN
fnp-3806	4620	7	,	,	PUNCT
fnp-3806	4620	8	portero	portero	PROPN
fnp-3806	4620	9	-	-	PUNCT
fnp-3806	4620	10	otín	otín	ADJ
fnp-3806	4620	11	m.	m.	NOUN
fnp-3806	4620	12	membrane	membrane	NOUN
fnp-3806	4620	13	fatty	fatty	NOUN
fnp-3806	4620	14	acid	acid	NOUN
fnp-3806	4620	15	unsaturation	unsaturation	NOUN
fnp-3806	4620	16	,	,	PUNCT
fnp-3806	4620	17	protection	protection	NOUN
fnp-3806	4620	18	against	against	ADP
fnp-3806	4620	19	oxidative	oxidative	ADJ
fnp-3806	4620	20	stress	stress	NOUN
fnp-3806	4620	21	,	,	PUNCT
fnp-3806	4620	22	and	and	CCONJ
fnp-3806	4620	23	maximum	maximum	ADJ
fnp-3806	4620	24	life	life	NOUN
fnp-3806	4620	25	span	span	NOUN
fnp-3806	4620	26	:	:	PUNCT
fnp-3806	4620	27	a	a	DET
fnp-3806	4620	28	homeoviscous	homeoviscous	ADJ
fnp-3806	4620	29	-	-	PUNCT
fnp-3806	4620	30	longevity	longevity	NOUN
fnp-3806	4620	31	adaptation	adaptation	NOUN
fnp-3806	4620	32	?	?	PUNCT
fnp-3806	4621	1	ann	ann	PROPN
fnp-3806	4621	2	n	n	PROPN
fnp-3806	4621	3	y	y	PROPN
fnp-3806	4621	4	acad	acad	PROPN
fnp-3806	4621	5	sci	sci	PROPN
fnp-3806	4621	6	2002;959:475	2002;959:475	NUM
fnp-3806	4621	7	-	-	SYM
fnp-3806	4621	8	490	490	NUM
fnp-3806	4621	9	.	.	PUNCT
fnp-3806	4622	1	https://doi.org/10.1111/j.1749-6632.2002.tb02118.x	https://doi.org/10.1111/j.1749-6632.2002.tb02118.x	PROPN
fnp-3806	4622	2	hulbert	hulbert	PROPN
fnp-3806	4622	3	aj	aj	PROPN
fnp-3806	4622	4	,	,	PUNCT
fnp-3806	4622	5	pamplona	pamplona	PROPN
fnp-3806	4622	6	r	r	NOUN
fnp-3806	4622	7	,	,	PUNCT
fnp-3806	4622	8	buffenstein	buffenstein	ADV
fnp-3806	4622	9	r	r	NOUN
fnp-3806	4622	10	,	,	PUNCT
fnp-3806	4622	11	et	et	PROPN
fnp-3806	4622	12	al	al	PROPN
fnp-3806	4622	13	.	.	PUNCT
fnp-3806	4622	14	life	life	NOUN
fnp-3806	4622	15	and	and	CCONJ
fnp-3806	4622	16	death	death	NOUN
fnp-3806	4622	17	:	:	PUNCT
fnp-3806	4622	18	metabolic	metabolic	NOUN
fnp-3806	4622	19	rate	rate	NOUN
fnp-3806	4622	20	,	,	PUNCT
fnp-3806	4622	21	membrane	membrane	NOUN
fnp-3806	4622	22	composition	composition	NOUN
fnp-3806	4622	23	,	,	PUNCT
fnp-3806	4622	24	and	and	CCONJ
fnp-3806	4622	25	life	life	NOUN
fnp-3806	4622	26	span	span	NOUN
fnp-3806	4622	27	of	of	ADP
fnp-3806	4622	28	animals	animal	NOUN
fnp-3806	4622	29	.	.	PUNCT
fnp-3806	4623	1	physiol	physiol	PROPN
fnp-3806	4623	2	rev	rev	VERB
fnp-3806	4623	3	2007	2007	NUM
fnp-3806	4623	4	;	;	PUNCT
fnp-3806	4623	5	87:1175	87:1175	NUM
fnp-3806	4623	6	-	-	SYM
fnp-3806	4623	7	1213	1213	NUM
fnp-3806	4623	8	.	.	PUNCT
fnp-3806	4624	1	https://doi.org/10.1152/physrev.00047.2006	https://doi.org/10.1152/physrev.00047.2006	PROPN
fnp-3806	4624	2	pamplona	pamplona	PROPN
fnp-3806	4624	3	r	r	PROPN
fnp-3806	4624	4	,	,	PUNCT
fnp-3806	4624	5	ilieva	ilieva	PROPN
fnp-3806	4624	6	e	e	PROPN
fnp-3806	4624	7	,	,	PUNCT
fnp-3806	4624	8	ayala	ayala	PROPN
fnp-3806	4624	9	v	v	PROPN
fnp-3806	4624	10	,	,	PUNCT
fnp-3806	4624	11	bellmunt	bellmunt	PROPN
fnp-3806	4624	12	mj	mj	PROPN
fnp-3806	4624	13	,	,	PUNCT
fnp-3806	4624	14	et	et	PROPN
fnp-3806	4624	15	al	al	PROPN
fnp-3806	4624	16	.	.	PROPN
fnp-3806	4625	1	maillard	maillard	NOUN
fnp-3806	4625	2	reaction	reaction	NOUN
fnp-3806	4625	3	versus	versus	ADP
fnp-3806	4625	4	other	other	ADJ
fnp-3806	4625	5	nonenzymatic	nonenzymatic	ADJ
fnp-3806	4625	6	modifications	modification	NOUN
fnp-3806	4625	7	in	in	ADP
fnp-3806	4625	8	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4625	9	processes	process	NOUN
fnp-3806	4625	10	.	.	PUNCT
fnp-3806	4626	1	ann	ann	PROPN
fnp-3806	4626	2	ny	ny	PROPN
fnp-3806	4626	3	acad	acad	PROPN
fnp-3806	4626	4	sci	sci	PROPN
fnp-3806	4626	5	2008;1126:315	2008;1126:315	PROPN
fnp-3806	4626	6	-	-	PROPN
fnp-3806	4626	7	319	319	PROPN
fnp-3806	4626	8	.	.	PUNCT
fnp-3806	4627	1	https://doi.org/10.1196/annals.1433.014	https://doi.org/10.1196/annals.1433.014	PROPN
fnp-3806	4627	2	moller	moller	PROPN
fnp-3806	4627	3	m	m	PROPN
fnp-3806	4627	4	,	,	PUNCT
fnp-3806	4627	5	botti	botti	PROPN
fnp-3806	4627	6	h	h	NOUN
fnp-3806	4627	7	,	,	PUNCT
fnp-3806	4627	8	batthyany	batthyany	NOUN
fnp-3806	4627	9	c	c	NOUN
fnp-3806	4627	10	,	,	PUNCT
fnp-3806	4627	11	et	et	PROPN
fnp-3806	4627	12	al	al	PROPN
fnp-3806	4627	13	.	.	PUNCT
fnp-3806	4627	14	direct	direct	ADJ
fnp-3806	4627	15	measurement	measurement	NOUN
fnp-3806	4627	16	of	of	ADP
fnp-3806	4627	17	nitric	nitric	ADJ
fnp-3806	4627	18	oxide	oxide	NOUN
fnp-3806	4627	19	and	and	CCONJ
fnp-3806	4627	20	oxygen	oxygen	NOUN
fnp-3806	4627	21	partitioning	partitioning	NOUN
fnp-3806	4627	22	into	into	ADP
fnp-3806	4627	23	liposomes	liposome	NOUN
fnp-3806	4627	24	and	and	CCONJ
fnp-3806	4627	25	low	low	ADJ
fnp-3806	4627	26	density	density	NOUN
fnp-3806	4627	27	lipoprotein	lipoprotein	ADJ
fnp-3806	4627	28	.	.	PUNCT
fnp-3806	4628	1	j	j	PROPN
fnp-3806	4628	2	biol	biol	PROPN
fnp-3806	4628	3	chem	chem	NOUN
fnp-3806	4628	4	2005;280:8850	2005;280:8850	NOUN
fnp-3806	4628	5	-	-	SYM
fnp-3806	4628	6	8854	8854	NUM
fnp-3806	4628	7	.	.	PUNCT
fnp-3806	4629	1	https://doi.org/10.1074/jbc.m413699200	https://doi.org/10.1074/jbc.m413699200	NOUN
fnp-3806	4629	2	gamliel	gamliel	VERB
fnp-3806	4629	3	a	a	PRON
fnp-3806	4629	4	,	,	PUNCT
fnp-3806	4629	5	afri	afri	PROPN
fnp-3806	4629	6	m	m	PROPN
fnp-3806	4629	7	,	,	PUNCT
fnp-3806	4629	8	frimer	frimer	ADJ
fnp-3806	4629	9	aa	aa	NOUN
fnp-3806	4629	10	.	.	PUNCT
fnp-3806	4630	1	determining	determine	VERB
fnp-3806	4630	2	radical	radical	ADJ
fnp-3806	4630	3	penetration	penetration	NOUN
fnp-3806	4630	4	of	of	ADP
fnp-3806	4630	5	lipid	lipid	ADJ
fnp-3806	4630	6	bilayers	bilayer	NOUN
fnp-3806	4630	7	with	with	ADP
fnp-3806	4630	8	new	new	ADJ
fnp-3806	4630	9	lipophilic	lipophilic	ADJ
fnp-3806	4630	10	spin	spin	NOUN
fnp-3806	4630	11	traps	trap	NOUN
fnp-3806	4630	12	.	.	PUNCT
fnp-3806	4631	1	free	free	ADJ
fnp-3806	4631	2	rad	rad	PROPN
fnp-3806	4631	3	biol	biol	PROPN
fnp-3806	4631	4	med	me	VERB
fnp-3806	4631	5	2008;44:1394	2008;44:1394	PROPN
fnp-3806	4631	6	-	-	SYM
fnp-3806	4631	7	1405	1405	NUM
fnp-3806	4631	8	.	.	PUNCT
fnp-3806	4632	1	https://doi.org/10.1016/j.freeradbiomed.2007.12.028	https://doi.org/10.1016/j.freeradbiomed.2007.12.028	ADJ
fnp-3806	4632	2	bielski	bielski	ADJ
fnp-3806	4632	3	bh	bh	NOUN
fnp-3806	4632	4	,	,	PUNCT
fnp-3806	4632	5	arudi	arudi	PROPN
fnp-3806	4632	6	rl	rl	PROPN
fnp-3806	4632	7	,	,	PUNCT
fnp-3806	4632	8	sutherland	sutherland	PROPN
fnp-3806	4632	9	mw	mw	PROPN
fnp-3806	4632	10	.	.	PROPN
fnp-3806	4633	1	a	a	DET
fnp-3806	4633	2	study	study	NOUN
fnp-3806	4633	3	of	of	ADP
fnp-3806	4633	4	the	the	DET
fnp-3806	4633	5	reactivity	reactivity	NOUN
fnp-3806	4633	6	of	of	ADP
fnp-3806	4633	7	ho2	ho2	PROPN
fnp-3806	4633	8	/	/	SYM
fnp-3806	4633	9	o2with	o2with	PROPN
fnp-3806	4633	10	unsaturated	unsaturate	VERB
fnp-3806	4633	11	fatty	fatty	NOUN
fnp-3806	4633	12	acids	acid	NOUN
fnp-3806	4633	13	.	.	PUNCT
fnp-3806	4634	1	j	j	PROPN
fnp-3806	4634	2	biol	biol	PROPN
fnp-3806	4634	3	chem	chem	NOUN
fnp-3806	4634	4	1983;258:4759	1983;258:4759	NUM
fnp-3806	4634	5	-	-	SYM
fnp-3806	4634	6	4761	4761	NUM
fnp-3806	4634	7	.	.	PUNCT
fnp-3806	4635	1	pmid	pmid	NOUN
fnp-3806	4635	2	:	:	PUNCT
fnp-3806	4635	3	6833274	6833274	NUM
fnp-3806	4635	4	.	.	PUNCT
fnp-3806	4636	1	söderberg	söderberg	PROPN
fnp-3806	4636	2	m	m	PROPN
fnp-3806	4636	3	,	,	PUNCT
fnp-3806	4636	4	edlund	edlund	PROPN
fnp-3806	4636	5	c	c	PROPN
fnp-3806	4636	6	,	,	PUNCT
fnp-3806	4636	7	kristensson	kristensson	NOUN
fnp-3806	4636	8	k	k	PROPN
fnp-3806	4636	9	,	,	PUNCT
fnp-3806	4636	10	et	et	PROPN
fnp-3806	4636	11	al	al	PROPN
fnp-3806	4636	12	.	.	PUNCT
fnp-3806	4636	13	lipid	lipid	PROPN
fnp-3806	4636	14	compositions	composition	NOUN
fnp-3806	4636	15	of	of	ADP
fnp-3806	4636	16	different	different	ADJ
fnp-3806	4636	17	regions	region	NOUN
fnp-3806	4636	18	of	of	ADP
fnp-3806	4636	19	the	the	DET
fnp-3806	4636	20	human	human	ADJ
fnp-3806	4636	21	brain	brain	NOUN
fnp-3806	4636	22	during	during	ADP
fnp-3806	4636	23	aging	aging	NOUN
fnp-3806	4636	24	.	.	PUNCT
fnp-3806	4637	1	j	j	PROPN
fnp-3806	4637	2	neurochem	neurochem	PROPN
fnp-3806	4637	3	1990;54:415	1990;54:415	PROPN
fnp-3806	4637	4	-	-	SYM
fnp-3806	4637	5	423	423	NUM
fnp-3806	4637	6	.	.	PUNCT
fnp-3806	4638	1	https://doi.org/10.1111/j.1471-4159.1990.tb01889.x	https://doi.org/10.1111/j.1471-4159.1990.tb01889.x	PRON
fnp-3806	4638	2	svennerholm	svennerholm	PROPN
fnp-3806	4638	3	l	l	NOUN
fnp-3806	4638	4	,	,	PUNCT
fnp-3806	4638	5	boström	boström	ADV
fnp-3806	4639	1	k	k	NOUN
fnp-3806	4639	2	,	,	PUNCT
fnp-3806	4639	3	helander	helander	PROPN
fnp-3806	4639	4	cg	cg	PROPN
fnp-3806	4639	5	,	,	PUNCT
fnp-3806	4639	6	et	et	PROPN
fnp-3806	4639	7	al	al	PROPN
fnp-3806	4639	8	.	.	PUNCT
fnp-3806	4639	9	membrane	membrane	NOUN
fnp-3806	4639	10	lipids	lipid	NOUN
fnp-3806	4639	11	in	in	ADP
fnp-3806	4639	12	the	the	DET
fnp-3806	4639	13	aging	age	VERB
fnp-3806	4639	14	human	human	ADJ
fnp-3806	4639	15	brain	brain	NOUN
fnp-3806	4639	16	.	.	PUNCT
fnp-3806	4640	1	j	j	PROPN
fnp-3806	4640	2	neurochem	neurochem	PROPN
fnp-3806	4640	3	1991;56:2051	1991;56:2051	PROPN
fnp-3806	4640	4	-	-	NUM
fnp-3806	4640	5	2059	2059	NUM
fnp-3806	4640	6	.	.	PUNCT
fnp-3806	4641	1	https://doi.org/10.1111/j.1471-4159.1991.tb03466.x	https://doi.org/10.1111/j.1471-4159.1991.tb03466.x	ADJ
fnp-3806	4641	2	svennerholm	svennerholm	NOUN
fnp-3806	4641	3	l.	l.	NOUN
fnp-3806	4641	4	distribution	distribution	NOUN
fnp-3806	4641	5	and	and	CCONJ
fnp-3806	4641	6	fatty	fatty	NOUN
fnp-3806	4641	7	acid	acid	NOUN
fnp-3806	4641	8	composition	composition	NOUN
fnp-3806	4641	9	of	of	ADP
fnp-3806	4641	10	phosphoglycerides	phosphoglyceride	NOUN
fnp-3806	4641	11	in	in	ADP
fnp-3806	4641	12	normal	normal	ADJ
fnp-3806	4641	13	human	human	ADJ
fnp-3806	4641	14	brain	brain	NOUN
fnp-3806	4641	15	.	.	PUNCT
fnp-3806	4642	1	j	j	PROPN
fnp-3806	4642	2	lipid	lipid	PROPN
fnp-3806	4642	3	res	re	VERB
fnp-3806	4642	4	1968;9:570	1968;9:570	NOUN
fnp-3806	4642	5	-	-	SYM
fnp-3806	4642	6	579	579	NUM
fnp-3806	4642	7	.	.	PUNCT
fnp-3806	4643	1	pmid	pmid	NOUN
fnp-3806	4643	2	:	:	PUNCT
fnp-3806	4643	3	4302302	4302302	NUM
fnp-3806	4643	4	.	.	PUNCT
fnp-3806	4644	1	horrocks	horrock	VERB
fnp-3806	4644	2	la	la	PROPN
fnp-3806	4644	3	,	,	PUNCT
fnp-3806	4644	4	vanrollins	vanrollins	PROPN
fnp-3806	4644	5	m	m	PROPN
fnp-3806	4644	6	,	,	PUNCT
fnp-3806	4644	7	yates	yates	PROPN
fnp-3806	4644	8	aj	aj	PROPN
fnp-3806	4644	9	.	.	PROPN
fnp-3806	4644	10	lipid	lipid	NOUN
fnp-3806	4644	11	changes	change	NOUN
fnp-3806	4644	12	in	in	ADP
fnp-3806	4644	13	the	the	DET
fnp-3806	4644	14	ageing	age	VERB
fnp-3806	4644	15	brain	brain	NOUN
fnp-3806	4644	16	.	.	PUNCT
fnp-3806	4645	1	in	in	ADP
fnp-3806	4645	2	:	:	PUNCT
fnp-3806	4645	3	the	the	DET
fnp-3806	4645	4	molecular	molecular	ADJ
fnp-3806	4645	5	basis	basis	NOUN
fnp-3806	4645	6	of	of	ADP
fnp-3806	4645	7	neuropathology	neuropathology	NOUN
fnp-3806	4645	8	.	.	PUNCT
fnp-3806	4646	1	davinson	davinson	PROPN
fnp-3806	4646	2	an	an	PROPN
fnp-3806	4646	3	,	,	PUNCT
fnp-3806	4646	4	thompson	thompson	PROPN
fnp-3806	4646	5	rhs	rhs	PROPN
fnp-3806	4646	6	(	(	PUNCT
fnp-3806	4646	7	eds	ed	NOUN
fnp-3806	4646	8	)	)	PUNCT
fnp-3806	4646	9	,	,	PUNCT
fnp-3806	4646	10	edward	edward	PROPN
fnp-3806	4646	11	arnold	arnold	PROPN
fnp-3806	4646	12	,	,	PUNCT
fnp-3806	4646	13	1981	1981	NUM
fnp-3806	4646	14	de	de	PROPN
fnp-3806	4646	15	diego	diego	PROPN
fnp-3806	4646	16	i	i	PROPN
fnp-3806	4646	17	,	,	PUNCT
fnp-3806	4646	18	peleg	peleg	PROPN
fnp-3806	4646	19	s	s	PROPN
fnp-3806	4646	20	,	,	PUNCT
fnp-3806	4646	21	fuchs	fuchs	PROPN
fnp-3806	4646	22	b.	b.	PROPN
fnp-3806	4647	1	the	the	DET
fnp-3806	4647	2	role	role	NOUN
fnp-3806	4647	3	of	of	ADP
fnp-3806	4647	4	lipids	lipid	NOUN
fnp-3806	4647	5	in	in	ADP
fnp-3806	4647	6	aging	age	VERB
fnp-3806	4647	7	-	-	PUNCT
fnp-3806	4647	8	related	relate	VERB
fnp-3806	4647	9	metabolic	metabolic	NOUN
fnp-3806	4647	10	changes	change	NOUN
fnp-3806	4647	11	.	.	PUNCT
fnp-3806	4648	1	chem	chem	NOUN
fnp-3806	4648	2	phys	phy	NOUN
fnp-3806	4648	3	lipids	lipid	VERB
fnp-3806	4648	4	2019;222:59	2019;222:59	NUM
fnp-3806	4648	5	-	-	SYM
fnp-3806	4648	6	69	69	NUM
fnp-3806	4648	7	.	.	PUNCT
fnp-3806	4649	1	https://doi.org/10.1016/j.chemphyslip.2019.05.005	https://doi.org/10.1016/j.chemphyslip.2019.05.005	PROPN
fnp-3806	4649	2	johnson	johnson	PROPN
fnp-3806	4649	3	aa	aa	PROPN
fnp-3806	4649	4	,	,	PUNCT
fnp-3806	4649	5	stolzing	stolze	VERB
fnp-3806	4649	6	a.	a.	NOUN
fnp-3806	4649	7	the	the	DET
fnp-3806	4649	8	role	role	NOUN
fnp-3806	4649	9	of	of	ADP
fnp-3806	4649	10	lipid	lipid	ADJ
fnp-3806	4649	11	metabolism	metabolism	NOUN
fnp-3806	4649	12	in	in	ADP
fnp-3806	4649	13	aging	age	VERB
fnp-3806	4649	14	,	,	PUNCT
fnp-3806	4649	15	lifespan	lifespan	ADJ
fnp-3806	4649	16	regulation	regulation	NOUN
fnp-3806	4649	17	,	,	PUNCT
fnp-3806	4649	18	and	and	CCONJ
fnp-3806	4649	19	age	age	NOUN
fnp-3806	4649	20	-	-	PUNCT
fnp-3806	4649	21	related	relate	VERB
fnp-3806	4649	22	disease	disease	NOUN
fnp-3806	4649	23	.	.	PUNCT
fnp-3806	4650	1	aging	age	VERB
fnp-3806	4650	2	cell	cell	NOUN
fnp-3806	4650	3	2019;516	2019;516	NUM
fnp-3806	4650	4	:	:	PUNCT
fnp-3806	4650	5	e13048	e13048	PROPN
fnp-3806	4650	6	.	.	PROPN
fnp-3806	4650	7	https://doi.org/10.1111/acel.13048	https://doi.org/10.1111/acel.13048	NOUN
fnp-3806	4650	8	mcnamarark	mcnamarark	NOUN
fnp-3806	4650	9	,	,	PUNCT
fnp-3806	4650	10	liu	liu	PROPN
fnp-3806	4650	11	y	y	PROPN
fnp-3806	4650	12	,	,	PUNCT
fnp-3806	4650	13	jandacek	jandacek	PROPN
fnp-3806	4650	14	r	r	NOUN
fnp-3806	4650	15	,	,	PUNCT
fnp-3806	4650	16	rider	rider	NOUN
fnp-3806	4650	17	t	t	PROPN
fnp-3806	4650	18	,	,	PUNCT
fnp-3806	4650	19	et	et	PROPN
fnp-3806	4650	20	al	al	PROPN
fnp-3806	4650	21	.	.	PUNCT
fnp-3806	4651	1	the	the	DET
fnp-3806	4651	2	aging	age	VERB
fnp-3806	4651	3	human	human	ADJ
fnp-3806	4651	4	orbitofrontal	orbitofrontal	ADJ
fnp-3806	4651	5	cortex	cortex	NOUN
fnp-3806	4651	6	:	:	PUNCT
fnp-3806	4651	7	decreasing	decrease	VERB
fnp-3806	4651	8	polyunsaturated	polyunsaturated	ADJ
fnp-3806	4651	9	fatty	fatty	NOUN
fnp-3806	4651	10	acid	acid	NOUN
fnp-3806	4651	11	composition	composition	NOUN
fnp-3806	4651	12	and	and	CCONJ
fnp-3806	4651	13	associated	associate	VERB
fnp-3806	4651	14	increases	increase	NOUN
fnp-3806	4651	15	in	in	ADP
fnp-3806	4651	16	lipogenic	lipogenic	ADJ
fnp-3806	4651	17	gene	gene	NOUN
fnp-3806	4651	18	expression	expression	NOUN
fnp-3806	4651	19	and	and	CCONJ
fnp-3806	4651	20	stearoyl	stearoyl	ADJ
fnp-3806	4651	21	-	-	PUNCT
fnp-3806	4651	22	coa	coa	NOUN
fnp-3806	4651	23	desaturase	desaturase	NOUN
fnp-3806	4651	24	activity	activity	NOUN
fnp-3806	4651	25	.	.	PUNCT
fnp-3806	4652	1	prostaglandins	prostaglandin	NOUN
fnp-3806	4652	2	,	,	PUNCT
fnp-3806	4652	3	leukotrienes	leukotriene	NOUN
fnp-3806	4652	4	,	,	PUNCT
fnp-3806	4652	5	essent	essent	ADJ
fnp-3806	4652	6	fatty	fatty	NOUN
fnp-3806	4652	7	acids	acid	NOUN
fnp-3806	4652	8	2008;78:293	2008;78:293	NUM
fnp-3806	4652	9	-	-	SYM
fnp-3806	4652	10	304	304	NUM
fnp-3806	4652	11	.	.	PUNCT
fnp-3806	4653	1	https://doi.org/10.1016/j.plefa.2008.04.00	https://doi.org/10.1016/j.plefa.2008.04.00	PROPN
fnp-3806	4653	2	keller	keller	PROPN
fnp-3806	4653	3	jn	jn	PROPN
fnp-3806	4653	4	,	,	PUNCT
fnp-3806	4653	5	dimayuga	dimayuga	PROPN
fnp-3806	4653	6	e	e	PROPN
fnp-3806	4653	7	,	,	PUNCT
fnp-3806	4653	8	chen	chen	PROPN
fnp-3806	4653	9	q	q	PROPN
fnp-3806	4653	10	,	,	PUNCT
fnp-3806	4653	11	et	et	PROPN
fnp-3806	4653	12	al	al	PROPN
fnp-3806	4653	13	.	.	PUNCT
fnp-3806	4653	14	autophagy	autophagy	PROPN
fnp-3806	4653	15	,	,	PUNCT
fnp-3806	4653	16	proteasomes	proteasome	NOUN
fnp-3806	4653	17	,	,	PUNCT
fnp-3806	4653	18	lipofuscin	lipofuscin	VERB
fnp-3806	4653	19	,	,	PUNCT
fnp-3806	4653	20	and	and	CCONJ
fnp-3806	4653	21	oxidative	oxidative	ADJ
fnp-3806	4653	22	stress	stress	NOUN
fnp-3806	4653	23	in	in	ADP
fnp-3806	4653	24	the	the	DET
fnp-3806	4653	25	aging	age	VERB
fnp-3806	4653	26	brain	brain	NOUN
fnp-3806	4653	27	.	.	PUNCT
fnp-3806	4654	1	int	int	PROPN
fnp-3806	4654	2	j	j	PROPN
fnp-3806	4654	3	biochem	biochem	PROPN
fnp-3806	4654	4	cell	cell	NOUN
fnp-3806	4654	5	biol	biol	PROPN
fnp-3806	4654	6	2004;36	2004;36	NUM
fnp-3806	4654	7	:	:	PUNCT
fnp-3806	4654	8	2376	2376	NUM
fnp-3806	4654	9	-	-	SYM
fnp-3806	4654	10	2391	2391	NUM
fnp-3806	4654	11	.	.	PUNCT
fnp-3806	4655	1	https://doi.org/10.1016/j.biocel.2004.05.003	https://doi.org/10.1016/j.biocel.2004.05.003	NUM
fnp-3806	4655	2	double	double	PROPN
fnp-3806	4655	3	kl	kl	PROPN
fnp-3806	4655	4	,	,	PUNCT
fnp-3806	4655	5	dedov	dedov	PROPN
fnp-3806	4655	6	vn	vn	PROPN
fnp-3806	4655	7	,	,	PUNCT
fnp-3806	4655	8	fedorow	fedorow	PROPN
fnp-3806	4655	9	h	h	NOUN
fnp-3806	4655	10	,	,	PUNCT
fnp-3806	4655	11	et	et	PROPN
fnp-3806	4655	12	al	al	PROPN
fnp-3806	4655	13	.	.	PUNCT
fnp-3806	4656	1	the	the	DET
fnp-3806	4656	2	comparative	comparative	ADJ
fnp-3806	4656	3	biology	biology	NOUN
fnp-3806	4656	4	of	of	ADP
fnp-3806	4656	5	neuromelanin	neuromelanin	NOUN
fnp-3806	4656	6	and	and	CCONJ
fnp-3806	4656	7	lipofuscin	lipofuscin	VERB
fnp-3806	4656	8	in	in	ADP
fnp-3806	4656	9	the	the	DET
fnp-3806	4656	10	human	human	ADJ
fnp-3806	4656	11	brain	brain	NOUN
fnp-3806	4656	12	.	.	PUNCT
fnp-3806	4657	1	cell	cell	NOUN
fnp-3806	4657	2	mol	mol	ADP
fnp-3806	4657	3	life	life	NOUN
fnp-3806	4657	4	sci	sci	PROPN
fnp-3806	4657	5	2008;65:1669	2008;65:1669	NUM
fnp-3806	4657	6	-	-	SYM
fnp-3806	4657	7	1682	1682	NUM
fnp-3806	4657	8	.	.	PUNCT
fnp-3806	4658	1	porta	porta	PROPN
fnp-3806	4658	2	ea	ea	PROPN
fnp-3806	4658	3	.	.	PUNCT
fnp-3806	4659	1	advances	advance	NOUN
fnp-3806	4659	2	in	in	ADP
fnp-3806	4659	3	age	age	NOUN
fnp-3806	4659	4	pigment	pigment	NOUN
fnp-3806	4659	5	research	research	NOUN
fnp-3806	4659	6	.	.	PUNCT
fnp-3806	4660	1	arch	arch	ADJ
fnp-3806	4660	2	gerontol	gerontol	PROPN
fnp-3806	4660	3	geriat	geriat	PROPN
fnp-3806	4660	4	1991;12:303	1991;12:303	NUM
fnp-3806	4660	5	-	-	SYM
fnp-3806	4660	6	320	320	NUM
fnp-3806	4660	7	.	.	PUNCT
fnp-3806	4661	1	https://doi.org/10.1016/0167-4943(91)90036-p	https://doi.org/10.1016/0167-4943(91)90036-p	PROPN
fnp-3806	4661	2	jolly	jolly	PROPN
fnp-3806	4661	3	rd	rd	PROPN
fnp-3806	4661	4	,	,	PUNCT
fnp-3806	4661	5	douglas	douglas	PROPN
fnp-3806	4661	6	bv	bv	PROPN
fnp-3806	4661	7	,	,	PUNCT
fnp-3806	4661	8	davey	davey	NOUN
fnp-3806	4661	9	pm	pm	PROPN
fnp-3806	4661	10	,	,	PUNCT
fnp-3806	4661	11	et	et	PROPN
fnp-3806	4661	12	al	al	PROPN
fnp-3806	4661	13	.	.	PROPN
fnp-3806	4661	14	lipofuscin	lipofuscin	PROPN
fnp-3806	4661	15	in	in	ADP
fnp-3806	4661	16	bovine	bovine	NOUN
fnp-3806	4661	17	muscle	muscle	NOUN
fnp-3806	4661	18	and	and	CCONJ
fnp-3806	4661	19	brain	brain	NOUN
fnp-3806	4661	20	:	:	PUNCT
fnp-3806	4661	21	a	a	DET
fnp-3806	4661	22	model	model	NOUN
fnp-3806	4661	23	for	for	ADP
fnp-3806	4661	24	studying	study	VERB
fnp-3806	4661	25	age	age	NOUN
fnp-3806	4661	26	pigment	pigment	NOUN
fnp-3806	4661	27	.	.	PUNCT
fnp-3806	4662	1	gerontology	gerontology	NOUN
fnp-3806	4662	2	1965;41	1965;41	NUM
fnp-3806	4662	3	:	:	PUNCT
fnp-3806	4662	4	s283	s283	PROPN
fnp-3806	4662	5	-	-	PUNCT
fnp-3806	4662	6	s295	s295	PROPN
fnp-3806	4662	7	.	.	PUNCT
fnp-3806	4663	1	https://doi.org/10.1159/000213750	https://doi.org/10.1159/000213750	NOUN
fnp-3806	4663	2	ottis	ottis	PROPN
fnp-3806	4663	3	p	p	X
fnp-3806	4663	4	,	,	PUNCT
fnp-3806	4663	5	koppe	koppe	PROPN
fnp-3806	4663	6	k	k	PROPN
fnp-3806	4663	7	,	,	PUNCT
fnp-3806	4663	8	onisko	onisko	PROPN
fnp-3806	4663	9	b	b	PROPN
fnp-3806	4663	10	,	,	PUNCT
fnp-3806	4663	11	et	et	PROPN
fnp-3806	4663	12	al	al	PROPN
fnp-3806	4663	13	.	.	PROPN
fnp-3806	4664	1	human	human	PROPN
fnp-3806	4664	2	and	and	CCONJ
fnp-3806	4664	3	rat	rat	NOUN
fnp-3806	4664	4	brain	brain	NOUN
fnp-3806	4664	5	lipofuscin	lipofuscin	NUM
fnp-3806	4664	6	proteome	proteome	PROPN
fnp-3806	4664	7	.	.	PUNCT
fnp-3806	4665	1	proteomics	proteomic	NOUN
fnp-3806	4665	2	2012;12:2445	2012;12:2445	NUM
fnp-3806	4665	3	-	-	SYM
fnp-3806	4665	4	2454	2454	NUM
fnp-3806	4665	5	.	.	PUNCT
fnp-3806	4666	1	https://doi.org/10.1002/pmic.201100668	https://doi.org/10.1002/pmic.201100668	NOUN
fnp-3806	4666	2	pamplona	pamplona	PROPN
fnp-3806	4666	3	r	r	NOUN
fnp-3806	4666	4	,	,	PUNCT
fnp-3806	4666	5	dalfó	dalfó	NOUN
fnp-3806	4666	6	e	e	NOUN
fnp-3806	4666	7	,	,	PUNCT
fnp-3806	4666	8	ayala	ayala	PROPN
fnp-3806	4666	9	v	v	PROPN
fnp-3806	4666	10	,	,	PUNCT
fnp-3806	4666	11	et	et	PROPN
fnp-3806	4666	12	al	al	PROPN
fnp-3806	4666	13	.	.	PUNCT
fnp-3806	4666	14	proteins	protein	NOUN
fnp-3806	4666	15	in	in	ADP
fnp-3806	4666	16	human	human	ADJ
fnp-3806	4666	17	brain	brain	NOUN
fnp-3806	4666	18	cortex	cortex	NOUN
fnp-3806	4666	19	are	be	AUX
fnp-3806	4666	20	modified	modify	VERB
fnp-3806	4666	21	by	by	ADP
fnp-3806	4666	22	oxidation	oxidation	NOUN
fnp-3806	4666	23	,	,	PUNCT
fnp-3806	4666	24	glycoxidation	glycoxidation	NOUN
fnp-3806	4666	25	,	,	PUNCT
fnp-3806	4666	26	and	and	CCONJ
fnp-3806	4666	27	lipoxidation	lipoxidation	NOUN
fnp-3806	4666	28	:	:	PUNCT
fnp-3806	4666	29	effects	effect	NOUN
fnp-3806	4666	30	of	of	ADP
fnp-3806	4666	31	alzheimer	alzheimer	PROPN
fnp-3806	4666	32	disease	disease	NOUN
fnp-3806	4666	33	and	and	CCONJ
fnp-3806	4666	34	identification	identification	NOUN
fnp-3806	4666	35	of	of	ADP
fnp-3806	4666	36	lipoxidation	lipoxidation	NOUN
fnp-3806	4666	37	targets	target	NOUN
fnp-3806	4666	38	.	.	PUNCT
fnp-3806	4667	1	j	j	PROPN
fnp-3806	4667	2	biol	biol	PROPN
fnp-3806	4667	3	chem	chem	NOUN
fnp-3806	4667	4	2005	2005	NUM
fnp-3806	4667	5	;	;	PUNCT
fnp-3806	4667	6	280:21522	280:21522	NUM
fnp-3806	4667	7	-	-	SYM
fnp-3806	4667	8	21530	21530	NUM
fnp-3806	4667	9	.	.	PUNCT
fnp-3806	4668	1	https://doi.org/10.1074/jbc.m502255200	https://doi.org/10.1074/jbc.m502255200	X
fnp-3806	4668	2	haughey	haughey	PROPN
fnp-3806	4668	3	nj	nj	PROPN
fnp-3806	4668	4	,	,	PUNCT
fnp-3806	4668	5	bandaru	bandaru	PROPN
fnp-3806	4668	6	vv	vv	PROPN
fnp-3806	4668	7	,	,	PUNCT
fnp-3806	4668	8	bae	bae	PROPN
fnp-3806	4668	9	m	m	PROPN
fnp-3806	4668	10	,	,	PUNCT
fnp-3806	4668	11	et	et	PROPN
fnp-3806	4668	12	al	al	PROPN
fnp-3806	4668	13	.	.	PROPN
fnp-3806	4668	14	roles	role	NOUN
fnp-3806	4668	15	for	for	ADP
fnp-3806	4668	16	dysfunctional	dysfunctional	ADJ
fnp-3806	4668	17	sphingolipid	sphingolipid	NOUN
fnp-3806	4668	18	metabolism	metabolism	NOUN
fnp-3806	4668	19	in	in	ADP
fnp-3806	4668	20	alzheimer	alzheimer	PROPN
fnp-3806	4668	21	's	's	PART
fnp-3806	4668	22	disease	disease	NOUN
fnp-3806	4668	23	neuropathogenesis	neuropathogenesis	NOUN
fnp-3806	4668	24	.	.	PUNCT
fnp-3806	4669	1	biochim	biochim	PROPN
fnp-3806	4669	2	biophys	biophy	NOUN
fnp-3806	4669	3	acta	acta	PROPN
fnp-3806	4669	4	2010	2010	NUM
fnp-3806	4669	5	;	;	PUNCT
fnp-3806	4669	6	1801	1801	NUM
fnp-3806	4669	7	:	:	PUNCT
fnp-3806	4669	8	878	878	NUM
fnp-3806	4669	9	-	-	SYM
fnp-3806	4669	10	886	886	NUM
fnp-3806	4669	11	.	.	PUNCT
fnp-3806	4670	1	https://doi.org/10.1016/j.bbalip.2010.05.003	https://doi.org/10.1016/j.bbalip.2010.05.003	PROPN
fnp-3806	4670	2	frisardi	frisardi	PROPN
fnp-3806	4670	3	v	v	NOUN
fnp-3806	4670	4	,	,	PUNCT
fnp-3806	4670	5	panza	panza	PROPN
fnp-3806	4670	6	f	f	PROPN
fnp-3806	4670	7	,	,	PUNCT
fnp-3806	4670	8	seripa	seripa	ADJ
fnp-3806	4670	9	d	d	PROPN
fnp-3806	4670	10	,	,	PUNCT
fnp-3806	4670	11	et	et	PROPN
fnp-3806	4670	12	al	al	PROPN
fnp-3806	4670	13	.	.	PROPN
fnp-3806	4670	14	glycerophospholipids	glycerophospholipid	NOUN
fnp-3806	4670	15	and	and	CCONJ
fnp-3806	4670	16	glycerophospholipid	glycerophospholipid	NOUN
fnp-3806	4670	17	-	-	PUNCT
fnp-3806	4670	18	derived	derive	VERB
fnp-3806	4670	19	lipid	lipid	NOUN
fnp-3806	4670	20	mediators	mediator	NOUN
fnp-3806	4670	21	:	:	PUNCT
fnp-3806	4670	22	a	a	DET
fnp-3806	4670	23	complex	complex	ADJ
fnp-3806	4670	24	meshwork	meshwork	NOUN
fnp-3806	4670	25	in	in	ADP
fnp-3806	4670	26	alzheimer	alzheimer	PROPN
fnp-3806	4670	27	's	's	PART
fnp-3806	4670	28	disease	disease	NOUN
fnp-3806	4670	29	pathology	pathology	NOUN
fnp-3806	4670	30	.	.	PUNCT
fnp-3806	4671	1	progr	progr	NOUN
fnp-3806	4671	2	lipid	lipid	NOUN
fnp-3806	4671	3	res	re	NOUN
fnp-3806	4671	4	2011;50:313	2011;50:313	NUM
fnp-3806	4671	5	-	-	SYM
fnp-3806	4671	6	330	330	NUM
fnp-3806	4671	7	.	.	PUNCT
fnp-3806	4672	1	https://doi.org/10.1016/j.plipres.2011.06.001	https://doi.org/10.1016/j.plipres.2011.06.001	NUM
fnp-3806	4672	2	wood	wood	NOUN
fnp-3806	4672	3	pl	pl	PROPN
fnp-3806	4672	4	.	.	PROPN
fnp-3806	4672	5	lipidomics	lipidomic	NOUN
fnp-3806	4672	6	of	of	ADP
fnp-3806	4672	7	alzheimer	alzheimer	PROPN
fnp-3806	4672	8	's	's	PART
fnp-3806	4672	9	disease	disease	NOUN
fnp-3806	4672	10	:	:	PUNCT
fnp-3806	4672	11	current	current	ADJ
fnp-3806	4672	12	status	status	NOUN
fnp-3806	4672	13	.	.	PUNCT
fnp-3806	4673	1	alzheimer	alzheimer	PROPN
fnp-3806	4673	2	res	res	PROPN
fnp-3806	4673	3	ther	ther	ADV
fnp-3806	4673	4	2012	2012	NUM
fnp-3806	4673	5	;	;	PUNCT
fnp-3806	4673	6	4	4	NUM
fnp-3806	4673	7	:	:	SYM
fnp-3806	4673	8	5	5	NUM
fnp-3806	4673	9	.	.	X
fnp-3806	4673	10	https://doi.org/10.1186/alzrt103	https://doi.org/10.1186/alzrt103	NOUN
fnp-3806	4673	11	kosicek	kosicek	PROPN
fnp-3806	4673	12	m	m	PROPN
fnp-3806	4673	13	,	,	PUNCT
fnp-3806	4673	14	hecimovic	hecimovic	PROPN
fnp-3806	4673	15	s.	s.	PROPN
fnp-3806	4673	16	phospholipids	phospholipids	PROPN
fnp-3806	4673	17	and	and	CCONJ
fnp-3806	4673	18	alzheimer	alzheimer	PROPN
fnp-3806	4673	19	's	's	PART
fnp-3806	4673	20	disease	disease	NOUN
fnp-3806	4673	21	:	:	PUNCT
fnp-3806	4673	22	alterations	alteration	NOUN
fnp-3806	4673	23	,	,	PUNCT
fnp-3806	4673	24	mechanisms	mechanism	NOUN
fnp-3806	4673	25	and	and	CCONJ
fnp-3806	4673	26	potential	potential	ADJ
fnp-3806	4673	27	biomarkers	biomarker	NOUN
fnp-3806	4673	28	.	.	PUNCT
fnp-3806	4674	1	int	int	PROPN
fnp-3806	4674	2	j	j	PROPN
fnp-3806	4674	3	mol	mol	ADP
fnp-3806	4674	4	sci	sci	PROPN
fnp-3806	4674	5	2013;14:1310	2013;14:1310	PROPN
fnp-3806	4674	6	-	-	PROPN
fnp-3806	4674	7	1322	1322	NUM
fnp-3806	4674	8	.	.	PUNCT
fnp-3806	4675	1	https://doi.org/10.3390/ijms14011310	https://doi.org/10.3390/ijms14011310	PROPN
fnp-3806	4675	2	touboul	touboul	PROPN
fnp-3806	4675	3	d	d	PROPN
fnp-3806	4675	4	,	,	PUNCT
fnp-3806	4675	5	gaudin	gaudin	PROPN
fnp-3806	4675	6	m.	m.	NOUN
fnp-3806	4675	7	lipidomics	lipidomic	NOUN
fnp-3806	4675	8	of	of	ADP
fnp-3806	4675	9	alzheimer	alzheimer	PROPN
fnp-3806	4675	10	's	's	PART
fnp-3806	4675	11	disease	disease	NOUN
fnp-3806	4675	12	.	.	PUNCT
fnp-3806	4676	1	bioanalysis	bioanalysis	NOUN
fnp-3806	4676	2	2014	2014	NUM
fnp-3806	4676	3	;	;	PUNCT
fnp-3806	4676	4	6	6	NUM
fnp-3806	4676	5	:	:	SYM
fnp-3806	4676	6	541	541	NUM
fnp-3806	4676	7	-	-	SYM
fnp-3806	4676	8	561	561	NUM
fnp-3806	4676	9	.	.	PUNCT
fnp-3806	4677	1	https://doi.org/10.4155/bio.13.346	https://doi.org/10.4155/bio.13.346	ADJ
fnp-3806	4677	2	senanayake	senanayake	NOUN
fnp-3806	4677	3	v	v	NOUN
fnp-3806	4677	4	,	,	PUNCT
fnp-3806	4677	5	goodenowe	goodenowe	NOUN
fnp-3806	4677	6	db	db	PROPN
fnp-3806	4677	7	.	.	PUNCT
fnp-3806	4677	8	plasmalogen	plasmalogen	NOUN
fnp-3806	4677	9	deficiency	deficiency	NOUN
fnp-3806	4677	10	and	and	CCONJ
fnp-3806	4677	11	neuropathology	neuropathology	NOUN
fnp-3806	4677	12	in	in	ADP
fnp-3806	4677	13	alzheimer	alzheimer	PROPN
fnp-3806	4677	14	’s	’s	PART
fnp-3806	4677	15	disease	disease	NOUN
fnp-3806	4677	16	:	:	PUNCT
fnp-3806	4677	17	causation	causation	NOUN
fnp-3806	4677	18	or	or	CCONJ
fnp-3806	4677	19	coincidence	coincidence	NOUN
fnp-3806	4677	20	?	?	PUNCT
fnp-3806	4678	1	alzheimers	alzheimer	NOUN
fnp-3806	4678	2	dement	dement	PROPN
fnp-3806	4678	3	2019;5:524	2019;5:524	PROPN
fnp-3806	4678	4	-	-	PUNCT
fnp-3806	4678	5	532	532	NUM
fnp-3806	4678	6	.	.	PUNCT
fnp-3806	4678	7	https://doi.org/10.1016/j.trci.2019.08.003	https://doi.org/10.1016/j.trci.2019.08.003	PROPN
fnp-3806	4678	8	brosche	brosche	PROPN
fnp-3806	4678	9	t	t	PROPN
fnp-3806	4678	10	,	,	PUNCT
fnp-3806	4678	11	platt	platt	PROPN
fnp-3806	4678	12	d.	d.	PROPN
fnp-3806	4678	13	the	the	DET
fnp-3806	4678	14	biological	biological	ADJ
fnp-3806	4678	15	significance	significance	NOUN
fnp-3806	4678	16	of	of	ADP
fnp-3806	4678	17	plasmalogens	plasmalogen	NOUN
fnp-3806	4678	18	in	in	ADP
fnp-3806	4678	19	defense	defense	NOUN
fnp-3806	4678	20	against	against	ADP
fnp-3806	4678	21	oxidative	oxidative	ADJ
fnp-3806	4678	22	damage	damage	NOUN
fnp-3806	4678	23	.	.	PUNCT
fnp-3806	4679	1	exp	exp	NOUN
fnp-3806	4679	2	gerontol	gerontol	ADJ
fnp-3806	4679	3	1998;33:363	1998;33:363	NUM
fnp-3806	4679	4	-	-	PUNCT
fnp-3806	4679	5	369	369	NUM
fnp-3806	4679	6	.	.	PUNCT
fnp-3806	4680	1	https://doi.org/10.1016/s0531-5565(98)00014-x	https://doi.org/10.1016/s0531-5565(98)00014-x	PROPN
fnp-3806	4680	2	martínez	martínez	PROPN
fnp-3806	4680	3	a	a	PROPN
fnp-3806	4680	4	,	,	PUNCT
fnp-3806	4680	5	portero	portero	PROPN
fnp-3806	4680	6	-	-	PUNCT
fnp-3806	4680	7	otin	otin	PROPN
fnp-3806	4680	8	m	m	PROPN
fnp-3806	4680	9	,	,	PUNCT
fnp-3806	4680	10	pamplona	pamplona	PROPN
fnp-3806	4680	11	r	r	PROPN
fnp-3806	4680	12	,	,	PUNCT
fnp-3806	4680	13	et	et	PROPN
fnp-3806	4680	14	al	al	PROPN
fnp-3806	4680	15	.	.	PUNCT
fnp-3806	4681	1	protein	protein	NOUN
fnp-3806	4681	2	targets	target	NOUN
fnp-3806	4681	3	of	of	ADP
fnp-3806	4681	4	oxidative	oxidative	ADJ
fnp-3806	4681	5	damage	damage	NOUN
fnp-3806	4681	6	in	in	ADP
fnp-3806	4681	7	human	human	ADJ
fnp-3806	4681	8	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4681	9	diseases	disease	NOUN
fnp-3806	4681	10	with	with	ADP
fnp-3806	4681	11	abnormal	abnormal	ADJ
fnp-3806	4681	12	protein	protein	NOUN
fnp-3806	4681	13	aggregates	aggregate	NOUN
fnp-3806	4681	14	.	.	PUNCT
fnp-3806	4682	1	brain	brain	NOUN
fnp-3806	4682	2	pathol	pathol	NOUN
fnp-3806	4682	3	2010	2010	NUM
fnp-3806	4682	4	;	;	PUNCT
fnp-3806	4682	5	20:281	20:281	NUM
fnp-3806	4682	6	-	-	SYM
fnp-3806	4682	7	297	297	NUM
fnp-3806	4682	8	.	.	PUNCT
fnp-3806	4683	1	https://doi.org/10.1111/j.1750-3639.2009.00326.x	https://doi.org/10.1111/j.1750-3639.2009.00326.x	PROPN
fnp-3806	4683	2	sultana	sultana	PROPN
fnp-3806	4683	3	r	r	PROPN
fnp-3806	4683	4	,	,	PUNCT
fnp-3806	4683	5	perluigi	perluigi	PROPN
fnp-3806	4683	6	m	m	PROPN
fnp-3806	4683	7	,	,	PUNCT
fnp-3806	4683	8	butterfield	butterfield	PROPN
fnp-3806	4683	9	ad	ad	NOUN
fnp-3806	4683	10	.	.	PUNCT
fnp-3806	4684	1	lipid	lipid	NOUN
fnp-3806	4684	2	peroxidation	peroxidation	NOUN
fnp-3806	4684	3	triggers	trigger	NOUN
fnp-3806	4684	4	neurodegeneration	neurodegeneration	NOUN
fnp-3806	4684	5	:	:	PUNCT
fnp-3806	4684	6	a	a	DET
fnp-3806	4684	7	redox	redox	ADJ
fnp-3806	4684	8	proteomics	proteomic	NOUN
fnp-3806	4684	9	view	view	NOUN
fnp-3806	4684	10	into	into	ADP
fnp-3806	4684	11	the	the	DET
fnp-3806	4684	12	alzheimer	alzheimer	PROPN
fnp-3806	4684	13	disease	disease	NOUN
fnp-3806	4684	14	brain	brain	NOUN
fnp-3806	4684	15	.	.	PUNCT
fnp-3806	4685	1	free	free	PROPN
fnp-3806	4685	2	rad	rad	PROPN
fnp-3806	4685	3	biol	biol	PROPN
fnp-3806	4685	4	med	me	VERB
fnp-3806	4685	5	2013;62:157	2013;62:157	PROPN
fnp-3806	4685	6	-	-	SYM
fnp-3806	4685	7	169	169	NUM
fnp-3806	4685	8	.	.	PUNCT
fnp-3806	4686	1	https://doi.org/10.1016/j.freeradbiomed.2012.09.027	https://doi.org/10.1016/j.freeradbiomed.2012.09.027	ADJ
fnp-3806	4686	2	benseny	benseny	NOUN
fnp-3806	4686	3	-	-	PUNCT
fnp-3806	4686	4	cases	case	NOUN
fnp-3806	4686	5	n	n	CCONJ
fnp-3806	4686	6	,	,	PUNCT
fnp-3806	4686	7	klementieva	klementieva	PROPN
fnp-3806	4686	8	o	o	PROPN
fnp-3806	4686	9	,	,	PUNCT
fnp-3806	4686	10	cotte	cotte	PROPN
fnp-3806	4686	11	m	m	PROPN
fnp-3806	4686	12	,	,	PUNCT
fnp-3806	4686	13	et	et	PROPN
fnp-3806	4686	14	al	al	PROPN
fnp-3806	4686	15	.	.	PROPN
fnp-3806	4686	16	microspectroscopy	microspectroscopy	PROPN
fnp-3806	4686	17	(	(	PUNCT
fnp-3806	4686	18	μftir	μftir	ADJ
fnp-3806	4686	19	)	)	PUNCT
fnp-3806	4686	20	reveals	reveal	VERB
fnp-3806	4686	21	co	co	NOUN
fnp-3806	4686	22	-	-	NOUN
fnp-3806	4686	23	localization	localization	NOUN
fnp-3806	4686	24	of	of	ADP
fnp-3806	4686	25	lipid	lipid	NOUN
fnp-3806	4686	26	oxidation	oxidation	NOUN
fnp-3806	4686	27	and	and	CCONJ
fnp-3806	4686	28	amyloid	amyloid	NOUN
fnp-3806	4686	29	plaques	plaque	NOUN
fnp-3806	4686	30	in	in	ADP
fnp-3806	4686	31	human	human	ADJ
fnp-3806	4686	32	alzheimer	alzheimer	PROPN
fnp-3806	4686	33	disease	disease	NOUN
fnp-3806	4686	34	brains	brain	NOUN
fnp-3806	4686	35	.	.	PUNCT
fnp-3806	4687	1	anal	anal	ADJ
fnp-3806	4687	2	chem	chem	NOUN
fnp-3806	4687	3	2014;86:12047	2014;86:12047	ADV
fnp-3806	4687	4	-	-	PUNCT
fnp-3806	4687	5	12054	12054	NUM
fnp-3806	4687	6	.	.	PUNCT
fnp-3806	4688	1	https://doi.org/10.1021/ac502667b	https://doi.org/10.1021/ac502667b	PROPN
fnp-3806	4688	2	evans	evans	PROPN
fnp-3806	4688	3	rm	rm	PROPN
fnp-3806	4688	4	,	,	PUNCT
fnp-3806	4688	5	hui	hui	PROPN
fnp-3806	4688	6	s	s	PROPN
fnp-3806	4688	7	,	,	PUNCT
fnp-3806	4688	8	perkins	perkin	VERB
fnp-3806	4688	9	a	a	PRON
fnp-3806	4688	10	,	,	PUNCT
fnp-3806	4688	11	et	et	PROPN
fnp-3806	4688	12	al	al	PROPN
fnp-3806	4688	13	.	.	PROPN
fnp-3806	4688	14	cholesterol	cholesterol	PROPN
fnp-3806	4688	15	and	and	CCONJ
fnp-3806	4688	16	apoe	apoe	ADJ
fnp-3806	4688	17	genotype	genotype	NOUN
fnp-3806	4688	18	interact	interact	NOUN
fnp-3806	4688	19	to	to	PART
fnp-3806	4688	20	influence	influence	VERB
fnp-3806	4688	21	alzheimer	alzheimer	PROPN
fnp-3806	4688	22	disease	disease	NOUN
fnp-3806	4688	23	progression	progression	NOUN
fnp-3806	4688	24	.	.	PUNCT
fnp-3806	4689	1	neurology	neurology	NOUN
fnp-3806	4689	2	2004;62	2004;62	NUM
fnp-3806	4689	3	:	:	PUNCT
fnp-3806	4689	4	1869	1869	NUM
fnp-3806	4689	5	-	-	SYM
fnp-3806	4689	6	1871	1871	NUM
fnp-3806	4689	7	.	.	PUNCT
fnp-3806	4690	1	https://doi.org/10.1212/01.wnl.0000125323.15458.3f	https://doi.org/10.1212/01.wnl.0000125323.15458.3f	PROPN
fnp-3806	4690	2	bu	bu	PROPN
fnp-3806	4690	3	g.	g.	PROPN
fnp-3806	4690	4	apolipoprotein	apolipoprotein	PROPN
fnp-3806	4690	5	e	e	PROPN
fnp-3806	4690	6	and	and	CCONJ
fnp-3806	4690	7	its	its	PRON
fnp-3806	4690	8	receptors	receptor	NOUN
fnp-3806	4690	9	in	in	ADP
fnp-3806	4690	10	alzheimer	alzheimer	PROPN
fnp-3806	4690	11	’s	’s	PART
fnp-3806	4690	12	disease	disease	NOUN
fnp-3806	4690	13	:	:	PUNCT
fnp-3806	4690	14	pathways	pathway	NOUN
fnp-3806	4690	15	,	,	PUNCT
fnp-3806	4690	16	pathogenesis	pathogenesis	NOUN
fnp-3806	4690	17	and	and	CCONJ
fnp-3806	4690	18	therapy	therapy	NOUN
fnp-3806	4690	19	.	.	PUNCT
fnp-3806	4691	1	nat	nat	PROPN
fnp-3806	4691	2	rev	rev	VERB
fnp-3806	4691	3	neurosci	neurosci	PROPN
fnp-3806	4691	4	2009;10:333	2009;10:333	NOUN
fnp-3806	4691	5	-	-	PUNCT
fnp-3806	4691	6	344	344	NUM
fnp-3806	4691	7	.	.	PUNCT
fnp-3806	4692	1	https://doi.org/10.1038/nrn2620	https://doi.org/10.1038/nrn2620	PROPN
fnp-3806	4692	2	hope	hope	VERB
fnp-3806	4692	3	c	c	PROPN
fnp-3806	4692	4	,	,	PUNCT
fnp-3806	4692	5	mettenburg	mettenburg	PROPN
fnp-3806	4692	6	j	j	PROPN
fnp-3806	4692	7	,	,	PUNCT
fnp-3806	4692	8	gonias	gonias	PROPN
fnp-3806	4692	9	sl	sl	PROPN
fnp-3806	4692	10	,	,	PUNCT
fnp-3806	4692	11	et	et	PROPN
fnp-3806	4692	12	al	al	PROPN
fnp-3806	4692	13	.	.	PROPN
fnp-3806	4693	1	functional	functional	ADJ
fnp-3806	4693	2	analysis	analysis	NOUN
fnp-3806	4693	3	of	of	ADP
fnp-3806	4693	4	plasma	plasma	NOUN
fnp-3806	4693	5	α2	α2	PROPN
fnp-3806	4693	6	-	-	PUNCT
fnp-3806	4693	7	macroglobulin	macroglobulin	PROPN
fnp-3806	4693	8	from	from	ADP
fnp-3806	4693	9	alzheimer	alzheimer	PROPN
fnp-3806	4693	10	’s	’s	PART
fnp-3806	4693	11	disease	disease	NOUN
fnp-3806	4693	12	patients	patient	NOUN
fnp-3806	4693	13	with	with	ADP
fnp-3806	4693	14	the	the	DET
fnp-3806	4693	15	a2	a2	PROPN
fnp-3806	4693	16	m	m	NOUN
fnp-3806	4693	17	intronic	intronic	ADJ
fnp-3806	4693	18	deletion	deletion	NOUN
fnp-3806	4693	19	.	.	PUNCT
fnp-3806	4694	1	neurobiol	neurobiol	PROPN
fnp-3806	4694	2	dis	dis	PROPN
fnp-3806	4694	3	2003;14:504	2003;14:504	NUM
fnp-3806	4694	4	-	-	SYM
fnp-3806	4694	5	512	512	NUM
fnp-3806	4694	6	.	.	PUNCT
fnp-3806	4695	1	https://doi.org/10.1016/j.nbd.2003.08.005	https://doi.org/10.1016/j.nbd.2003.08.005	VERB
fnp-3806	4695	2	zappia	zappia	PROPN
fnp-3806	4695	3	m	m	PROPN
fnp-3806	4695	4	,	,	PUNCT
fnp-3806	4695	5	manna	manna	NOUN
fnp-3806	4695	6	i	i	PRON
fnp-3806	4695	7	,	,	PUNCT
fnp-3806	4695	8	serra	serra	PROPN
fnp-3806	4695	9	p	p	PROPN
fnp-3806	4695	10	,	,	PUNCT
fnp-3806	4695	11	et	et	PROPN
fnp-3806	4695	12	al	al	PROPN
fnp-3806	4695	13	.	.	PROPN
fnp-3806	4695	14	increased	increase	VERB
fnp-3806	4695	15	risk	risk	NOUN
fnp-3806	4695	16	for	for	ADP
fnp-3806	4695	17	alzheimer	alzheimer	NOUN
fnp-3806	4695	18	disease	disease	NOUN
fnp-3806	4695	19	with	with	ADP
fnp-3806	4695	20	the	the	DET
fnp-3806	4695	21	interaction	interaction	NOUN
fnp-3806	4695	22	of	of	ADP
fnp-3806	4695	23	mpo	mpo	PROPN
fnp-3806	4695	24	and	and	CCONJ
fnp-3806	4695	25	a2	a2	PROPN
fnp-3806	4695	26	m	m	PROPN
fnp-3806	4695	27	polymorphisms	polymorphism	NOUN
fnp-3806	4695	28	.	.	PUNCT
fnp-3806	4696	1	arch	arch	ADJ
fnp-3806	4696	2	neurol	neurol	PROPN
fnp-3806	4696	3	2004;61:341	2004;61:341	PROPN
fnp-3806	4696	4	-	-	SYM
fnp-3806	4696	5	344	344	NUM
fnp-3806	4696	6	.	.	PUNCT
fnp-3806	4697	1	https://doi.org/10.1001/archneur.61.3.341	https://doi.org/10.1001/archneur.61.3.341	PROPN
fnp-3806	4697	2	marzolo	marzolo	PROPN
fnp-3806	4697	3	mp	mp	PROPN
fnp-3806	4697	4	,	,	PUNCT
fnp-3806	4697	5	bu	bu	PROPN
fnp-3806	4697	6	g.	g.	PROPN
fnp-3806	4697	7	lipoprotein	lipoprotein	ADJ
fnp-3806	4697	8	receptors	receptor	NOUN
fnp-3806	4697	9	and	and	CCONJ
fnp-3806	4697	10	cholesterol	cholesterol	NOUN
fnp-3806	4697	11	in	in	ADP
fnp-3806	4697	12	app	app	NOUN
fnp-3806	4697	13	trafficking	trafficking	NOUN
fnp-3806	4697	14	and	and	CCONJ
fnp-3806	4697	15	proteolytic	proteolytic	ADJ
fnp-3806	4697	16	processing	processing	NOUN
fnp-3806	4697	17	,	,	PUNCT
fnp-3806	4697	18	implications	implication	NOUN
fnp-3806	4697	19	for	for	ADP
fnp-3806	4697	20	alzheimer	alzheimer	PROPN
fnp-3806	4697	21	’s	’s	PART
fnp-3806	4697	22	disease	disease	NOUN
fnp-3806	4697	23	.	.	PUNCT
fnp-3806	4698	1	semin	semin	PROPN
fnp-3806	4698	2	cell	cell	PROPN
fnp-3806	4698	3	dev	dev	PROPN
fnp-3806	4698	4	biol	biol	PROPN
fnp-3806	4698	5	2009;20:191	2009;20:191	PROPN
fnp-3806	4698	6	-	-	SYM
fnp-3806	4698	7	200	200	NUM
fnp-3806	4698	8	.	.	PUNCT
fnp-3806	4699	1	https://doi.org/10.1016/j.semcdb.2008.10.005	https://doi.org/10.1016/j.semcdb.2008.10.005	PROPN
fnp-3806	4699	2	jones	jones	PROPN
fnp-3806	4699	3	em	em	PRON
fnp-3806	4699	4	,	,	PUNCT
fnp-3806	4699	5	dubey	dubey	PROPN
fnp-3806	4699	6	m	m	PROPN
fnp-3806	4699	7	,	,	PUNCT
fnp-3806	4699	8	camp	camp	PROPN
fnp-3806	4699	9	pj	pj	PROPN
fnp-3806	4699	10	,	,	PUNCT
fnp-3806	4699	11	et	et	PROPN
fnp-3806	4699	12	al	al	PROPN
fnp-3806	4699	13	.	.	PUNCT
fnp-3806	4699	14	interaction	interaction	NOUN
fnp-3806	4699	15	of	of	ADP
fnp-3806	4699	16	tau	tau	PROPN
fnp-3806	4699	17	protein	protein	NOUN
fnp-3806	4699	18	with	with	ADP
fnp-3806	4699	19	model	model	NOUN
fnp-3806	4699	20	lipid	lipid	NOUN
fnp-3806	4699	21	membranes	membrane	NOUN
fnp-3806	4699	22	induces	induce	VERB
fnp-3806	4699	23	tau	tau	PROPN
fnp-3806	4699	24	structural	structural	ADJ
fnp-3806	4699	25	compaction	compaction	NOUN
fnp-3806	4699	26	and	and	CCONJ
fnp-3806	4699	27	membrane	membrane	NOUN
fnp-3806	4699	28	disruption	disruption	NOUN
fnp-3806	4699	29	.	.	PUNCT
fnp-3806	4700	1	biochemistry	biochemistry	NOUN
fnp-3806	4700	2	2012;51:2539	2012;51:2539	NUM
fnp-3806	4700	3	-	-	SYM
fnp-3806	4700	4	2550	2550	NUM
fnp-3806	4700	5	.	.	PUNCT
fnp-3806	4701	1	https://doi.org/10.1021/bi201857v	https://doi.org/10.1021/bi201857v	PROPN
fnp-3806	4701	2	morgan	morgan	PROPN
fnp-3806	4701	3	k.	k.	PROPN
fnp-3806	4701	4	the	the	DET
fnp-3806	4701	5	three	three	NUM
fnp-3806	4701	6	new	new	ADJ
fnp-3806	4701	7	pathways	pathway	NOUN
fnp-3806	4701	8	leading	lead	VERB
fnp-3806	4701	9	to	to	ADP
fnp-3806	4701	10	alzheimer	alzheimer	PROPN
fnp-3806	4701	11	’s	’s	PART
fnp-3806	4701	12	disease	disease	NOUN
fnp-3806	4701	13	.	.	PUNCT
fnp-3806	4702	1	neuropathol	neuropathol	PROPN
fnp-3806	4702	2	appl	appl	PROPN
fnp-3806	4702	3	neurobiol	neurobiol	PROPN
fnp-3806	4702	4	2011;37:353	2011;37:353	NUM
fnp-3806	4702	5	-	-	SYM
fnp-3806	4702	6	357	357	NUM
fnp-3806	4702	7	.	.	PUNCT
fnp-3806	4703	1	https://doi.org/10.1111/j.1365-2990.2011.01181.x	https://doi.org/10.1111/j.1365-2990.2011.01181.x	NOUN
fnp-3806	4704	1	d	d	PROPN
fnp-3806	4704	2	bruce	bruce	PROPN
fnp-3806	4704	3	k	k	PROPN
fnp-3806	4704	4	,	,	PUNCT
fnp-3806	4704	5	tang	tang	PROPN
fnp-3806	4704	6	m	m	PROPN
fnp-3806	4704	7	,	,	PUNCT
fnp-3806	4704	8	reigan	reigan	VERB
fnp-3806	4704	9	p	p	X
fnp-3806	4704	10	,	,	PUNCT
fnp-3806	4704	11	et	et	PROPN
fnp-3806	4704	12	al	al	PROPN
fnp-3806	4704	13	.	.	PUNCT
fnp-3806	4705	1	genetic	genetic	ADJ
fnp-3806	4705	2	variants	variant	NOUN
fnp-3806	4705	3	of	of	ADP
fnp-3806	4705	4	lipoprotein	lipoprotein	ADJ
fnp-3806	4705	5	lipase	lipase	NOUN
fnp-3806	4705	6	and	and	CCONJ
fnp-3806	4705	7	regulatory	regulatory	ADJ
fnp-3806	4705	8	factors	factor	NOUN
fnp-3806	4705	9	associated	associate	VERB
fnp-3806	4705	10	with	with	ADP
fnp-3806	4705	11	alzheimer	alzheimer	PROPN
fnp-3806	4705	12	's	's	PART
fnp-3806	4705	13	disease	disease	NOUN
fnp-3806	4705	14	risk	risk	NOUN
fnp-3806	4705	15	.	.	PUNCT
fnp-3806	4706	1	int	int	PROPN
fnp-3806	4706	2	j	j	PROPN
fnp-3806	4706	3	mol	mol	ADP
fnp-3806	4706	4	sci	sci	PROPN
fnp-3806	4706	5	2020;21:8338	2020;21:8338	NUM
fnp-3806	4706	6	https://doi.org/10.3390/ijms21218338	https://doi.org/10.3390/ijms21218338	PROPN
fnp-3806	4706	7	robinson	robinson	PROPN
fnp-3806	4706	8	jl	jl	PROPN
fnp-3806	4706	9	,	,	PUNCT
fnp-3806	4706	10	lee	lee	PROPN
fnp-3806	4706	11	eb	eb	PROPN
fnp-3806	4706	12	,	,	PUNCT
fnp-3806	4706	13	xie	xie	PROPN
fnp-3806	4706	14	sx	sx	PROPN
fnp-3806	4706	15	,	,	PUNCT
fnp-3806	4706	16	et	et	PROPN
fnp-3806	4706	17	al	al	PROPN
fnp-3806	4706	18	.	.	PROPN
fnp-3806	4706	19	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4706	20	disease	disease	NOUN
fnp-3806	4706	21	concomitant	concomitant	ADJ
fnp-3806	4706	22	proteinopathies	proteinopathie	NOUN
fnp-3806	4706	23	are	be	AUX
fnp-3806	4706	24	prevalent	prevalent	ADJ
fnp-3806	4706	25	,	,	PUNCT
fnp-3806	4706	26	age	age	NOUN
fnp-3806	4706	27	-	-	PUNCT
fnp-3806	4706	28	related	relate	VERB
fnp-3806	4706	29	and	and	CCONJ
fnp-3806	4706	30	apoe4	apoe4	PROPN
fnp-3806	4706	31	-	-	PUNCT
fnp-3806	4706	32	associated	associate	VERB
fnp-3806	4706	33	.	.	PUNCT
fnp-3806	4707	1	brain	brain	NOUN
fnp-3806	4707	2	2018;141:2181	2018;141:2181	NUM
fnp-3806	4707	3	-	-	SYM
fnp-3806	4707	4	2193	2193	NUM
fnp-3806	4707	5	.	.	PUNCT
fnp-3806	4708	1	https://doi.org/10.1093/brain/awy146	https://doi.org/10.1093/brain/awy146	PROPN
fnp-3806	4708	2	robinson	robinson	PROPN
fnp-3806	4708	3	ac	ac	PROPN
fnp-3806	4708	4	,	,	PUNCT
fnp-3806	4708	5	davidson	davidson	PROPN
fnp-3806	4708	6	ys	ys	PROPN
fnp-3806	4708	7	,	,	PUNCT
fnp-3806	4708	8	roncaroli	roncaroli	PROPN
fnp-3806	4708	9	f	f	PROPN
fnp-3806	4708	10	,	,	PUNCT
fnp-3806	4708	11	et	et	PROPN
fnp-3806	4708	12	al	al	PROPN
fnp-3806	4708	13	.	.	PUNCT
fnp-3806	4708	14	influence	influence	NOUN
fnp-3806	4708	15	of	of	ADP
fnp-3806	4708	16	apoe	apoe	ADJ
fnp-3806	4708	17	genotype	genotype	NOUN
fnp-3806	4708	18	in	in	ADP
fnp-3806	4708	19	primary	primary	ADJ
fnp-3806	4708	20	age	age	NOUN
fnp-3806	4708	21	-	-	PUNCT
fnp-3806	4708	22	related	relate	VERB
fnp-3806	4708	23	tauopathy	tauopathy	NOUN
fnp-3806	4708	24	.	.	PUNCT
fnp-3806	4709	1	acta	acta	PROPN
fnp-3806	4709	2	neuropathol	neuropathol	PROPN
fnp-3806	4709	3	commun	commun	PROPN
fnp-3806	4709	4	2020	2020	NUM
fnp-3806	4709	5	;	;	PUNCT
fnp-3806	4710	1	8:215	8:215	X
fnp-3806	4710	2	.	.	PUNCT
fnp-3806	4711	1	https://doi.org/10.1186/s40478-020-01095-1	https://doi.org/10.1186/s40478-020-01095-1	PROPN
fnp-3806	4711	2	lingwood	lingwood	ADJ
fnp-3806	4711	3	d	d	PROPN
fnp-3806	4711	4	,	,	PUNCT
fnp-3806	4711	5	simons	simons	PROPN
fnp-3806	4711	6	k.	k.	PROPN
fnp-3806	4711	7	lipid	lipid	PROPN
fnp-3806	4711	8	rafts	raft	NOUN
fnp-3806	4711	9	as	as	ADP
fnp-3806	4711	10	a	a	DET
fnp-3806	4711	11	membrane	membrane	NOUN
fnp-3806	4711	12	-	-	PUNCT
fnp-3806	4711	13	organizing	organize	VERB
fnp-3806	4711	14	principle	principle	NOUN
fnp-3806	4711	15	.	.	PUNCT
fnp-3806	4712	1	science	science	NOUN
fnp-3806	4712	2	2010;327:46	2010;327:46	NUM
fnp-3806	4712	3	-	-	SYM
fnp-3806	4712	4	50	50	NUM
fnp-3806	4712	5	.	.	PUNCT
fnp-3806	4713	1	https://doi.org/10.1126/science.1174621	https://doi.org/10.1126/science.1174621	PROPN
fnp-3806	4713	2	sezgin	sezgin	VERB
fnp-3806	4713	3	e	e	NOUN
fnp-3806	4713	4	,	,	PUNCT
fnp-3806	4713	5	levental	levental	PROPN
fnp-3806	4713	6	i	i	PROPN
fnp-3806	4713	7	,	,	PUNCT
fnp-3806	4713	8	mayor	mayor	NOUN
fnp-3806	4713	9	s	s	PART
fnp-3806	4713	10	,	,	PUNCT
fnp-3806	4713	11	et	et	PROPN
fnp-3806	4713	12	al	al	PROPN
fnp-3806	4713	13	.	.	PUNCT
fnp-3806	4714	1	the	the	DET
fnp-3806	4714	2	mystery	mystery	NOUN
fnp-3806	4714	3	of	of	ADP
fnp-3806	4714	4	membrane	membrane	NOUN
fnp-3806	4714	5	organization	organization	NOUN
fnp-3806	4714	6	:	:	PUNCT
fnp-3806	4714	7	composition	composition	NOUN
fnp-3806	4714	8	,	,	PUNCT
fnp-3806	4714	9	regulation	regulation	NOUN
fnp-3806	4714	10	and	and	CCONJ
fnp-3806	4714	11	roles	role	NOUN
fnp-3806	4714	12	of	of	ADP
fnp-3806	4714	13	lipid	lipid	ADJ
fnp-3806	4714	14	rafts	raft	NOUN
fnp-3806	4714	15	.	.	PUNCT
fnp-3806	4715	1	nat	nat	PROPN
fnp-3806	4715	2	rev	rev	VERB
fnp-3806	4715	3	mol	mol	ADP
fnp-3806	4715	4	cell	cell	NOUN
fnp-3806	4715	5	biol	biol	NOUN
fnp-3806	4715	6	2017;18:361	2017;18:361	NOUN
fnp-3806	4715	7	-	-	SYM
fnp-3806	4715	8	374	374	NUM
fnp-3806	4715	9	.	.	PUNCT
fnp-3806	4716	1	https://doi.org/10.1038/nrm.2017.16	https://doi.org/10.1038/nrm.2017.16	PROPN
fnp-3806	4716	2	tatulian	tatulian	PROPN
fnp-3806	4716	3	sa	sa	PROPN
fnp-3806	4716	4	,	,	PUNCT
fnp-3806	4716	5	qin	qin	PROPN
fnp-3806	4716	6	s	s	PROPN
fnp-3806	4716	7	,	,	PUNCT
fnp-3806	4716	8	pande	pande	NOUN
fnp-3806	4716	9	ah	ah	INTJ
fnp-3806	4716	10	,	,	PUNCT
fnp-3806	4716	11	et	et	PROPN
fnp-3806	4716	12	al	al	PROPN
fnp-3806	4716	13	.	.	PUNCT
fnp-3806	4716	14	positioning	position	VERB
fnp-3806	4716	15	membrane	membrane	NOUN
fnp-3806	4716	16	proteins	protein	NOUN
fnp-3806	4716	17	by	by	ADP
fnp-3806	4716	18	novel	novel	ADJ
fnp-3806	4716	19	protein	protein	NOUN
fnp-3806	4716	20	engineering	engineering	NOUN
fnp-3806	4716	21	and	and	CCONJ
fnp-3806	4716	22	biophysical	biophysical	ADJ
fnp-3806	4716	23	approaches	approach	NOUN
fnp-3806	4716	24	.	.	PUNCT
fnp-3806	4717	1	j	j	PROPN
fnp-3806	4717	2	mol	mol	ADP
fnp-3806	4717	3	biol	biol	PROPN
fnp-3806	4717	4	2005;351:939	2005;351:939	NUM
fnp-3806	4717	5	-	-	SYM
fnp-3806	4717	6	947	947	NUM
fnp-3806	4717	7	.	.	PUNCT
fnp-3806	4718	1	https://doi.org/10.1016/j.jmb.2005.06.080	https://doi.org/10.1016/j.jmb.2005.06.080	NOUN
fnp-3806	4718	2	tun	tun	PROPN
fnp-3806	4718	3	h	h	NOUN
fnp-3806	4718	4	,	,	PUNCT
fnp-3806	4718	5	marlow	marlow	ADJ
fnp-3806	4718	6	l	l	NOUN
fnp-3806	4718	7	,	,	PUNCT
fnp-3806	4718	8	pinnix	pinnix	PROPN
fnp-3806	4718	9	i	i	PRON
fnp-3806	4718	10	,	,	PUNCT
fnp-3806	4718	11	et	et	PROPN
fnp-3806	4718	12	al	al	PROPN
fnp-3806	4718	13	.	.	PROPN
fnp-3806	4719	1	lipid	lipid	PROPN
fnp-3806	4719	2	rafts	raft	NOUN
fnp-3806	4719	3	play	play	VERB
fnp-3806	4719	4	an	an	DET
fnp-3806	4719	5	important	important	ADJ
fnp-3806	4719	6	role	role	NOUN
fnp-3806	4719	7	in	in	ADP
fnp-3806	4719	8	aβ	aβ	NOUN
fnp-3806	4719	9	biogenesis	biogenesis	NOUN
fnp-3806	4719	10	by	by	ADP
fnp-3806	4719	11	regulating	regulate	VERB
fnp-3806	4719	12	the	the	DET
fnp-3806	4719	13	β	β	NOUN
fnp-3806	4719	14	-	-	ADJ
fnp-3806	4719	15	secretase	secretase	ADJ
fnp-3806	4719	16	pathway	pathway	NOUN
fnp-3806	4719	17	.	.	PUNCT
fnp-3806	4720	1	j	j	PROPN
fnp-3806	4720	2	mol	mol	ADP
fnp-3806	4720	3	neurosci	neurosci	PROPN
fnp-3806	4720	4	2002;19:31	2002;19:31	NUM
fnp-3806	4720	5	-	-	SYM
fnp-3806	4720	6	35	35	NUM
fnp-3806	4720	7	.	.	PUNCT
fnp-3806	4721	1	https://doi.org/10.1007/s12031-002-0007-5	https://doi.org/10.1007/s12031-002-0007-5	PROPN
fnp-3806	4721	2	ehehalt	ehehalt	NOUN
fnp-3806	4721	3	r	r	NOUN
fnp-3806	4721	4	,	,	PUNCT
fnp-3806	4721	5	keller	keller	PROPN
fnp-3806	4721	6	p	p	NOUN
fnp-3806	4721	7	,	,	PUNCT
fnp-3806	4721	8	haass	haass	VERB
fnp-3806	4721	9	c	c	NOUN
fnp-3806	4721	10	,	,	PUNCT
fnp-3806	4721	11	et	et	PROPN
fnp-3806	4721	12	al	al	PROPN
fnp-3806	4721	13	.	.	PROPN
fnp-3806	4721	14	amyloidogenic	amyloidogenic	ADJ
fnp-3806	4721	15	processing	processing	NOUN
fnp-3806	4721	16	of	of	ADP
fnp-3806	4721	17	the	the	DET
fnp-3806	4721	18	alzheimer	alzheimer	PROPN
fnp-3806	4721	19	β	β	NOUN
fnp-3806	4721	20	-	-	ADJ
fnp-3806	4721	21	amyloid	amyloid	ADJ
fnp-3806	4721	22	precursor	precursor	NOUN
fnp-3806	4721	23	protein	protein	NOUN
fnp-3806	4721	24	depends	depend	VERB
fnp-3806	4721	25	on	on	ADP
fnp-3806	4721	26	lipid	lipid	ADJ
fnp-3806	4721	27	rafts	raft	NOUN
fnp-3806	4721	28	.	.	PUNCT
fnp-3806	4722	1	j	j	PROPN
fnp-3806	4722	2	cell	cell	NOUN
fnp-3806	4722	3	biol	biol	PROPN
fnp-3806	4722	4	2003;160:113	2003;160:113	NUM
fnp-3806	4722	5	-	-	SYM
fnp-3806	4722	6	123	123	NUM
fnp-3806	4722	7	.	.	PUNCT
fnp-3806	4723	1	https://doi.org/10.1083/jcb.200207113	https://doi.org/10.1083/jcb.200207113	PROPN
fnp-3806	4723	2	kawarabayashi	kawarabayashi	PROPN
fnp-3806	4723	3	t	t	PROPN
fnp-3806	4723	4	,	,	PUNCT
fnp-3806	4723	5	shoji	shoji	PROPN
fnp-3806	4723	6	m	m	PROPN
fnp-3806	4723	7	,	,	PUNCT
fnp-3806	4723	8	younkin	younkin	ADJ
fnp-3806	4723	9	lh	lh	PROPN
fnp-3806	4723	10	,	,	PUNCT
fnp-3806	4723	11	et	et	PROPN
fnp-3806	4723	12	al	al	PROPN
fnp-3806	4723	13	.	.	PROPN
fnp-3806	4724	1	dimeric	dimeric	ADJ
fnp-3806	4724	2	amyloid	amyloid	NOUN
fnp-3806	4724	3	beta	beta	NOUN
fnp-3806	4724	4	protein	protein	NOUN
fnp-3806	4724	5	rapidly	rapidly	ADV
fnp-3806	4724	6	accumulates	accumulate	VERB
fnp-3806	4724	7	in	in	ADP
fnp-3806	4724	8	lipid	lipid	ADJ
fnp-3806	4724	9	rafts	raft	NOUN
fnp-3806	4724	10	followed	follow	VERB
fnp-3806	4724	11	by	by	ADP
fnp-3806	4724	12	apoilipoprotein	apoilipoprotein	ADJ
fnp-3806	4724	13	e	e	PROPN
fnp-3806	4724	14	and	and	CCONJ
fnp-3806	4724	15	phosphorylated	phosphorylate	VERB
fnp-3806	4724	16	tau	tau	PROPN
fnp-3806	4724	17	accumulation	accumulation	NOUN
fnp-3806	4724	18	in	in	ADP
fnp-3806	4724	19	the	the	DET
fnp-3806	4724	20	tg2576	tg2576	PROPN
fnp-3806	4724	21	mouse	mouse	NOUN
fnp-3806	4724	22	model	model	NOUN
fnp-3806	4724	23	of	of	ADP
fnp-3806	4724	24	alzheimer	alzheimer	PROPN
fnp-3806	4724	25	’s	’s	PART
fnp-3806	4724	26	disease	disease	NOUN
fnp-3806	4724	27	.	.	PUNCT
fnp-3806	4725	1	j	j	PROPN
fnp-3806	4725	2	neurosci	neurosci	PROPN
fnp-3806	4725	3	2004;24:3801	2004;24:3801	PROPN
fnp-3806	4725	4	-	-	SYM
fnp-3806	4725	5	3809	3809	NUM
fnp-3806	4725	6	.	.	PUNCT
fnp-3806	4726	1	https://doi.org/10.1523/jneurosci.5543-03.2004	https://doi.org/10.1523/jneurosci.5543-03.2004	PROPN
fnp-3806	4726	2	williamson	williamson	PROPN
fnp-3806	4726	3	r	r	PROPN
fnp-3806	4726	4	,	,	PUNCT
fnp-3806	4726	5	usardi	usardi	PROPN
fnp-3806	4726	6	a	a	PRON
fnp-3806	4726	7	,	,	PUNCT
fnp-3806	4726	8	hanger	hanger	NOUN
fnp-3806	4726	9	dp	dp	NOUN
fnp-3806	4726	10	,	,	PUNCT
fnp-3806	4726	11	et	et	PROPN
fnp-3806	4726	12	al	al	PROPN
fnp-3806	4726	13	.	.	PROPN
fnp-3806	4726	14	membrane	membrane	NOUN
fnp-3806	4726	15	-	-	PUNCT
fnp-3806	4726	16	bound	bind	VERB
fnp-3806	4726	17	β	β	NOUN
fnp-3806	4726	18	-	-	NOUN
fnp-3806	4726	19	amyloid	amyloid	ADJ
fnp-3806	4726	20	oligomers	oligomer	NOUN
fnp-3806	4726	21	are	be	AUX
fnp-3806	4726	22	recruited	recruit	VERB
fnp-3806	4726	23	into	into	ADP
fnp-3806	4726	24	lipid	lipid	ADJ
fnp-3806	4726	25	rafts	raft	NOUN
fnp-3806	4726	26	by	by	ADP
fnp-3806	4726	27	a	a	DET
fnp-3806	4726	28	fyn	fyn	PROPN
fnp-3806	4726	29	-	-	PUNCT
fnp-3806	4726	30	dependent	dependent	ADJ
fnp-3806	4726	31	mechanism	mechanism	NOUN
fnp-3806	4726	32	.	.	PUNCT
fnp-3806	4727	1	faseb	faseb	PROPN
fnp-3806	4727	2	j	j	PROPN
fnp-3806	4727	3	2008;22:1552	2008;22:1552	NUM
fnp-3806	4727	4	-	-	SYM
fnp-3806	4727	5	1559	1559	NUM
fnp-3806	4727	6	.	.	PUNCT
fnp-3806	4728	1	https://doi.org/10.1096/fj.07-9766com	https://doi.org/10.1096/fj.07-9766com	X
fnp-3806	4728	2	williamson	williamson	PROPN
fnp-3806	4728	3	r	r	PROPN
fnp-3806	4728	4	,	,	PUNCT
fnp-3806	4728	5	sutherland	sutherland	PROPN
fnp-3806	4728	6	c.	c.	PROPN
fnp-3806	4728	7	neuronal	neuronal	ADJ
fnp-3806	4728	8	membranes	membrane	NOUN
fnp-3806	4728	9	are	be	AUX
fnp-3806	4728	10	key	key	ADJ
fnp-3806	4728	11	to	to	ADP
fnp-3806	4728	12	the	the	DET
fnp-3806	4728	13	pathogenesis	pathogenesis	NOUN
fnp-3806	4728	14	of	of	ADP
fnp-3806	4728	15	alzheimer	alzheimer	PROPN
fnp-3806	4728	16	's	's	PART
fnp-3806	4728	17	disease	disease	NOUN
fnp-3806	4728	18	:	:	PUNCT
fnp-3806	4728	19	the	the	DET
fnp-3806	4728	20	role	role	NOUN
fnp-3806	4728	21	of	of	ADP
fnp-3806	4728	22	both	both	DET
fnp-3806	4728	23	raft	raft	NOUN
fnp-3806	4728	24	and	and	CCONJ
fnp-3806	4728	25	non	non	ADJ
fnp-3806	4728	26	-	-	ADJ
fnp-3806	4728	27	raft	raft	ADJ
fnp-3806	4728	28	membrane	membrane	NOUN
fnp-3806	4728	29	domains	domain	NOUN
fnp-3806	4728	30	.	.	PUNCT
fnp-3806	4729	1	curr	curr	PROPN
fnp-3806	4729	2	alzheimer	alzheimer	PROPN
fnp-3806	4729	3	res	res	PROPN
fnp-3806	4729	4	20118:213	20118:213	PROPN
fnp-3806	4729	5	-	-	SYM
fnp-3806	4729	6	221	221	NUM
fnp-3806	4729	7	.	.	PUNCT
fnp-3806	4730	1	https://doi.org/10.2174/156720511795256008	https://doi.org/10.2174/156720511795256008	NOUN
fnp-3806	4730	2	fabiani	fabiani	PROPN
fnp-3806	4730	3	c	c	PROPN
fnp-3806	4730	4	,	,	PUNCT
fnp-3806	4730	5	antollini	antollini	PROPN
fnp-3806	4730	6	ss	ss	PROPN
fnp-3806	4730	7	.	.	PROPN
fnp-3806	4730	8	alzheimer	alzheimer	PROPN
fnp-3806	4730	9	's	's	PART
fnp-3806	4730	10	disease	disease	NOUN
fnp-3806	4730	11	as	as	ADP
fnp-3806	4730	12	a	a	DET
fnp-3806	4730	13	membrane	membrane	NOUN
fnp-3806	4730	14	disorder	disorder	NOUN
fnp-3806	4730	15	:	:	PUNCT
fnp-3806	4730	16	spatial	spatial	ADJ
fnp-3806	4730	17	cross	cross	NOUN
fnp-3806	4730	18	-	-	NOUN
fnp-3806	4730	19	talk	talk	NOUN
fnp-3806	4730	20	among	among	ADP
fnp-3806	4730	21	β	β	ADJ
fnp-3806	4730	22	-	-	ADJ
fnp-3806	4730	23	amyloid	amyloid	ADJ
fnp-3806	4730	24	peptides	peptide	NOUN
fnp-3806	4730	25	,	,	PUNCT
fnp-3806	4730	26	nicotinic	nicotinic	ADJ
fnp-3806	4730	27	acetylcholine	acetylcholine	NOUN
fnp-3806	4730	28	receptors	receptor	NOUN
fnp-3806	4730	29	and	and	CCONJ
fnp-3806	4730	30	lipid	lipid	NOUN
fnp-3806	4730	31	rafts	raft	NOUN
fnp-3806	4730	32	.	.	PUNCT
fnp-3806	4731	1	front	front	ADJ
fnp-3806	4731	2	cell	cell	NOUN
fnp-3806	4731	3	neurosci	neurosci	NOUN
fnp-3806	4731	4	2019;13:309	2019;13:309	NUM
fnp-3806	4731	5	.	.	PUNCT
fnp-3806	4732	1	https://doi.org/10.3389/fncel.2019.00309	https://doi.org/10.3389/fncel.2019.00309	PROPN
fnp-3806	4732	2	fabelo	fabelo	VERB
fnp-3806	4732	3	n	n	CCONJ
fnp-3806	4732	4	,	,	PUNCT
fnp-3806	4732	5	martín	martín	NOUN
fnp-3806	4732	6	v	v	PROPN
fnp-3806	4732	7	,	,	PUNCT
fnp-3806	4732	8	marín	marín	PROPN
fnp-3806	4732	9	r	r	NOUN
fnp-3806	4732	10	,	,	PUNCT
fnp-3806	4732	11	et	et	PROPN
fnp-3806	4732	12	al	al	PROPN
fnp-3806	4732	13	.	.	PROPN
fnp-3806	4732	14	evidence	evidence	NOUN
fnp-3806	4732	15	for	for	ADP
fnp-3806	4732	16	premature	premature	ADJ
fnp-3806	4732	17	lipid	lipid	NOUN
fnp-3806	4732	18	raft	raft	NOUN
fnp-3806	4732	19	aging	aging	NOUN
fnp-3806	4732	20	in	in	ADP
fnp-3806	4732	21	app	app	PROPN
fnp-3806	4732	22	/	/	SYM
fnp-3806	4732	23	ps1	ps1	NOUN
fnp-3806	4732	24	double	double	ADJ
fnp-3806	4732	25	-	-	PUNCT
fnp-3806	4732	26	transgenic	transgenic	NOUN
fnp-3806	4732	27	mice	mouse	NOUN
fnp-3806	4732	28	,	,	PUNCT
fnp-3806	4732	29	a	a	DET
fnp-3806	4732	30	model	model	NOUN
fnp-3806	4732	31	of	of	ADP
fnp-3806	4732	32	familial	familial	ADJ
fnp-3806	4732	33	alzheimer	alzheimer	PROPN
fnp-3806	4732	34	disease	disease	NOUN
fnp-3806	4732	35	.	.	PUNCT
fnp-3806	4733	1	j	j	PROPN
fnp-3806	4733	2	neuropathol	neuropathol	PROPN
fnp-3806	4733	3	exp	exp	PROPN
fnp-3806	4733	4	neurol	neurol	NOUN
fnp-3806	4733	5	.	.	PUNCT
fnp-3806	4734	1	2012;71:868	2012;71:868	X
fnp-3806	4734	2	-	-	PUNCT
fnp-3806	4734	3	881	881	NUM
fnp-3806	4734	4	.	.	PUNCT
fnp-3806	4735	1	https://doi.org/10.1097/nen.0b013e31826be03c	https://doi.org/10.1097/nen.0b013e31826be03c	PROPN
fnp-3806	4735	2	takahashi	takahashi	PROPN
fnp-3806	4735	3	rh	rh	PROPN
fnp-3806	4735	4	,	,	PUNCT
fnp-3806	4735	5	tobiume	tobiume	PROPN
fnp-3806	4735	6	m	m	PROPN
fnp-3806	4735	7	,	,	PUNCT
fnp-3806	4735	8	sato	sato	PROPN
fnp-3806	4735	9	y	y	PROPN
fnp-3806	4735	10	,	,	PUNCT
fnp-3806	4735	11	et	et	PROPN
fnp-3806	4735	12	al	al	PROPN
fnp-3806	4735	13	.	.	PROPN
fnp-3806	4735	14	accumulation	accumulation	NOUN
fnp-3806	4735	15	of	of	ADP
fnp-3806	4735	16	cellular	cellular	ADJ
fnp-3806	4735	17	prion	prion	NOUN
fnp-3806	4735	18	protein	protein	NOUN
fnp-3806	4735	19	within	within	ADP
fnp-3806	4735	20	dystrophic	dystrophic	ADJ
fnp-3806	4735	21	neurites	neurite	NOUN
fnp-3806	4735	22	of	of	ADP
fnp-3806	4735	23	amyloid	amyloid	NOUN
fnp-3806	4735	24	plaques	plaque	NOUN
fnp-3806	4735	25	in	in	ADP
fnp-3806	4735	26	the	the	DET
fnp-3806	4735	27	alzheimer	alzheimer	NOUN
fnp-3806	4735	28	's	's	PART
fnp-3806	4735	29	disease	disease	NOUN
fnp-3806	4735	30	brain	brain	NOUN
fnp-3806	4735	31	.	.	PUNCT
fnp-3806	4736	1	neuropathology	neuropathology	NOUN
fnp-3806	4736	2	2011;31:208	2011;31:208	PROPN
fnp-3806	4736	3	-	-	SYM
fnp-3806	4736	4	214	214	NUM
fnp-3806	4736	5	.	.	PUNCT
fnp-3806	4737	1	https://doi.org/10.1111/j.1440-1789.2010.01158.x	https://doi.org/10.1111/j.1440-1789.2010.01158.x	PROPN
fnp-3806	4737	2	takahashi	takahashi	PROPN
fnp-3806	4737	3	rh	rh	PROPN
fnp-3806	4737	4	,	,	PUNCT
fnp-3806	4737	5	yokotsuka	yokotsuka	PROPN
fnp-3806	4737	6	m	m	PROPN
fnp-3806	4737	7	,	,	PUNCT
fnp-3806	4737	8	tobiume	tobiume	PROPN
fnp-3806	4737	9	m	m	PROPN
fnp-3806	4737	10	,	,	PUNCT
fnp-3806	4737	11	et	et	PROPN
fnp-3806	4737	12	al	al	PROPN
fnp-3806	4737	13	.	.	PROPN
fnp-3806	4737	14	accumulation	accumulation	NOUN
fnp-3806	4737	15	of	of	ADP
fnp-3806	4737	16	cellular	cellular	ADJ
fnp-3806	4737	17	prion	prion	NOUN
fnp-3806	4737	18	protein	protein	NOUN
fnp-3806	4737	19	within	within	ADP
fnp-3806	4737	20	β	β	NOUN
fnp-3806	4737	21	-	-	ADJ
fnp-3806	4737	22	amyloid	amyloid	ADJ
fnp-3806	4737	23	oligomer	oligomer	ADJ
fnp-3806	4737	24	plaques	plaque	NOUN
fnp-3806	4737	25	in	in	ADP
fnp-3806	4737	26	aged	aged	ADJ
fnp-3806	4737	27	human	human	ADJ
fnp-3806	4737	28	brains	brain	NOUN
fnp-3806	4737	29	.	.	PUNCT
fnp-3806	4738	1	brain	brain	NOUN
fnp-3806	4738	2	pathol	pathol	NOUN
fnp-3806	4738	3	2021;31	2021;31	NUM
fnp-3806	4738	4	:	:	PUNCT
fnp-3806	4738	5	e12941	e12941	ADJ
fnp-3806	4738	6	.	.	PUNCT
fnp-3806	4739	1	https://doi.org/10.1111/bpa.12941	https://doi.org/10.1111/bpa.12941	PROPN
fnp-3806	4739	2	díaz	díaz	PROPN
fnp-3806	4739	3	m	m	PROPN
fnp-3806	4739	4	,	,	PUNCT
fnp-3806	4739	5	fabelo	fabelo	NOUN
fnp-3806	4739	6	n	n	NUM
fnp-3806	4739	7	,	,	PUNCT
fnp-3806	4739	8	ferrer	ferrer	PROPN
fnp-3806	4739	9	i	i	PROPN
fnp-3806	4739	10	,	,	PUNCT
fnp-3806	4739	11	et	et	PROPN
fnp-3806	4739	12	al	al	PROPN
fnp-3806	4739	13	.	.	PUNCT
fnp-3806	4740	1	“	"	PUNCT
fnp-3806	4740	2	lipid	lipid	ADJ
fnp-3806	4740	3	raft	raft	NOUN
fnp-3806	4740	4	aging	aging	NOUN
fnp-3806	4740	5	”	"	PUNCT
fnp-3806	4740	6	in	in	ADP
fnp-3806	4740	7	the	the	DET
fnp-3806	4740	8	human	human	ADJ
fnp-3806	4740	9	frontal	frontal	ADJ
fnp-3806	4740	10	cortex	cortex	NOUN
fnp-3806	4740	11	during	during	ADP
fnp-3806	4740	12	nonpathological	nonpathological	ADJ
fnp-3806	4740	13	aging	aging	NOUN
fnp-3806	4740	14	:	:	PUNCT
fnp-3806	4740	15	gender	gender	NOUN
fnp-3806	4740	16	influences	influence	NOUN
fnp-3806	4740	17	and	and	CCONJ
fnp-3806	4740	18	potential	potential	ADJ
fnp-3806	4740	19	implications	implication	NOUN
fnp-3806	4740	20	in	in	ADP
fnp-3806	4740	21	alzheimer	alzheimer	PROPN
fnp-3806	4740	22	's	's	PART
fnp-3806	4740	23	disease	disease	NOUN
fnp-3806	4740	24	.	.	PUNCT
fnp-3806	4741	1	neurobiol	neurobiol	PROPN
fnp-3806	4741	2	aging	age	VERB
fnp-3806	4741	3	2018;67:42	2018;67:42	NOUN
fnp-3806	4741	4	-	-	SYM
fnp-3806	4741	5	52	52	NUM
fnp-3806	4741	6	.	.	PUNCT
fnp-3806	4742	1	https://doi.org/10.1016/j.neurobiolaging.2018.02.022	https://doi.org/10.1016/j.neurobiolaging.2018.02.022	NOUN
fnp-3806	4742	2	fabelo	fabelo	NOUN
fnp-3806	4742	3	n	n	NOUN
fnp-3806	4742	4	,	,	PUNCT
fnp-3806	4742	5	martín	martín	NOUN
fnp-3806	4742	6	v	v	PROPN
fnp-3806	4742	7	,	,	PUNCT
fnp-3806	4742	8	marín	marín	PROPN
fnp-3806	4742	9	r	r	NOUN
fnp-3806	4742	10	,	,	PUNCT
fnp-3806	4742	11	et	et	PROPN
fnp-3806	4742	12	al	al	PROPN
fnp-3806	4742	13	.	.	PROPN
fnp-3806	4742	14	altered	alter	VERB
fnp-3806	4742	15	lipid	lipid	NOUN
fnp-3806	4742	16	composition	composition	NOUN
fnp-3806	4742	17	in	in	ADP
fnp-3806	4742	18	cortical	cortical	ADJ
fnp-3806	4742	19	lipid	lipid	NOUN
fnp-3806	4742	20	rafts	raft	NOUN
fnp-3806	4742	21	occurs	occur	VERB
fnp-3806	4742	22	at	at	ADP
fnp-3806	4742	23	early	early	ADJ
fnp-3806	4742	24	stages	stage	NOUN
fnp-3806	4742	25	of	of	ADP
fnp-3806	4742	26	sporadic	sporadic	ADJ
fnp-3806	4742	27	alzheimer	alzheimer	PROPN
fnp-3806	4742	28	's	's	PART
fnp-3806	4742	29	disease	disease	NOUN
fnp-3806	4742	30	and	and	CCONJ
fnp-3806	4742	31	facilitates	facilitate	VERB
fnp-3806	4742	32	app	app	PROPN
fnp-3806	4742	33	/	/	SYM
fnp-3806	4742	34	bace1	bace1	NOUN
fnp-3806	4742	35	interactions	interaction	NOUN
fnp-3806	4742	36	.	.	PUNCT
fnp-3806	4743	1	neurobiol	neurobiol	ADJ
fnp-3806	4743	2	aging	age	VERB
fnp-3806	4743	3	2014;35:1801	2014;35:1801	NUM
fnp-3806	4743	4	-	-	SYM
fnp-3806	4743	5	1812	1812	NUM
fnp-3806	4743	6	.	.	PUNCT
fnp-3806	4744	1	https://doi.org/10.1016/j.neurobiolaging.2014.02.005	https://doi.org/10.1016/j.neurobiolaging.2014.02.005	PROPN
fnp-3806	4744	2	díaz	díaz	PROPN
fnp-3806	4744	3	m	m	PROPN
fnp-3806	4744	4	,	,	PUNCT
fnp-3806	4744	5	fabelo	fabelo	ADJ
fnp-3806	4744	6	n	n	NUM
fnp-3806	4744	7	,	,	PUNCT
fnp-3806	4744	8	martín	martín	NOUN
fnp-3806	4744	9	v	v	PROPN
fnp-3806	4744	10	,	,	PUNCT
fnp-3806	4744	11	et	et	PROPN
fnp-3806	4744	12	al	al	PROPN
fnp-3806	4744	13	.	.	PUNCT
fnp-3806	4745	1	biophysical	biophysical	ADJ
fnp-3806	4745	2	alterations	alteration	NOUN
fnp-3806	4745	3	in	in	ADP
fnp-3806	4745	4	lipid	lipid	ADJ
fnp-3806	4745	5	rafts	raft	NOUN
fnp-3806	4745	6	from	from	ADP
fnp-3806	4745	7	human	human	ADJ
fnp-3806	4745	8	cerebral	cerebral	ADJ
fnp-3806	4745	9	cortex	cortex	NOUN
fnp-3806	4745	10	associate	associate	NOUN
fnp-3806	4745	11	with	with	ADP
fnp-3806	4745	12	increased	increase	VERB
fnp-3806	4745	13	bace1	bace1	NOUN
fnp-3806	4745	14	/	/	SYM
fnp-3806	4745	15	aβpp	aβpp	NOUN
fnp-3806	4745	16	interaction	interaction	NOUN
fnp-3806	4745	17	in	in	ADP
fnp-3806	4745	18	early	early	ADJ
fnp-3806	4745	19	stages	stage	NOUN
fnp-3806	4745	20	of	of	ADP
fnp-3806	4745	21	alzheimer	alzheimer	PROPN
fnp-3806	4745	22	's	's	PART
fnp-3806	4745	23	disease	disease	NOUN
fnp-3806	4745	24	.	.	PUNCT
fnp-3806	4746	1	j	j	PROPN
fnp-3806	4746	2	alzheimers	alzheimers	PROPN
fnp-3806	4746	3	dis	dis	PROPN
fnp-3806	4746	4	2015;43:1185	2015;43:1185	NUM
fnp-3806	4746	5	-	-	SYM
fnp-3806	4746	6	1198	1198	NUM
fnp-3806	4746	7	.	.	PUNCT
fnp-3806	4747	1	https://doi.org/10.3233/jad-141146	https://doi.org/10.3233/jad-141146	PROPN
fnp-3806	4747	2	chi	chi	PROPN
fnp-3806	4747	3	ey	ey	PROPN
fnp-3806	4747	4	,	,	PUNCT
fnp-3806	4747	5	ege	ege	PROPN
fnp-3806	4747	6	c	c	NOUN
fnp-3806	4747	7	,	,	PUNCT
fnp-3806	4747	8	winans	winans	PROPN
fnp-3806	4747	9	a	a	X
fnp-3806	4747	10	,	,	PUNCT
fnp-3806	4747	11	et	et	PROPN
fnp-3806	4747	12	al	al	PROPN
fnp-3806	4747	13	.	.	PROPN
fnp-3806	4747	14	lipid	lipid	PROPN
fnp-3806	4747	15	membrane	membrane	NOUN
fnp-3806	4747	16	templates	template	NOUN
fnp-3806	4747	17	the	the	DET
fnp-3806	4747	18	ordering	ordering	NOUN
fnp-3806	4747	19	and	and	CCONJ
fnp-3806	4747	20	induces	induce	VERB
fnp-3806	4747	21	the	the	DET
fnp-3806	4747	22	fibrillogenesis	fibrillogenesis	NOUN
fnp-3806	4747	23	of	of	ADP
fnp-3806	4747	24	alzheimer	alzheimer	PROPN
fnp-3806	4747	25	's	's	PART
fnp-3806	4747	26	disease	disease	NOUN
fnp-3806	4747	27	amyloid	amyloid	NOUN
fnp-3806	4747	28	-	-	PUNCT
fnp-3806	4747	29	beta	beta	NOUN
fnp-3806	4747	30	peptide	peptide	NOUN
fnp-3806	4747	31	.	.	PUNCT
fnp-3806	4748	1	proteins	protein	NOUN
fnp-3806	4748	2	2008;72:1	2008;72:1	NOUN
fnp-3806	4748	3	-	-	SYM
fnp-3806	4748	4	24	24	NUM
fnp-3806	4748	5	.	.	PUNCT
fnp-3806	4749	1	https://doi.org/10.1002/prot.21887	https://doi.org/10.1002/prot.21887	PROPN
fnp-3806	4749	2	vetrivel	vetrivel	PROPN
fnp-3806	4749	3	ks	ks	PROPN
fnp-3806	4749	4	,	,	PUNCT
fnp-3806	4749	5	thinarkaran	thinarkaran	NOUN
fnp-3806	4749	6	g.	g.	PROPN
fnp-3806	4749	7	membrane	membrane	NOUN
fnp-3806	4749	8	rafts	raft	NOUN
fnp-3806	4749	9	in	in	ADP
fnp-3806	4749	10	alzheimer	alzheimer	PROPN
fnp-3806	4749	11	's	's	PART
fnp-3806	4749	12	disease	disease	NOUN
fnp-3806	4749	13	beta	beta	NOUN
fnp-3806	4749	14	-	-	PUNCT
fnp-3806	4749	15	amyloid	amyloid	NOUN
fnp-3806	4749	16	production	production	NOUN
fnp-3806	4749	17	.	.	PUNCT
fnp-3806	4750	1	biochem	biochem	PROPN
fnp-3806	4750	2	biophys	biophys	PROPN
fnp-3806	4750	3	acta	acta	VERB
fnp-3806	4750	4	molecular	molecular	ADJ
fnp-3806	4750	5	and	and	CCONJ
fnp-3806	4750	6	cell	cell	NOUN
fnp-3806	4750	7	biology	biology	NOUN
fnp-3806	4750	8	of	of	ADP
fnp-3806	4750	9	lipids	lipids	ADJ
fnp-3806	4750	10	2010;1801:860	2010;1801:860	PROPN
fnp-3806	4750	11	-	-	PUNCT
fnp-3806	4750	12	867	867	NUM
fnp-3806	4750	13	.	.	PUNCT
fnp-3806	4751	1	https://doi.org/10.1016/j.bbalip.2010.03.007	https://doi.org/10.1016/j.bbalip.2010.03.007	VERB
fnp-3806	4751	2	relini	relini	PROPN
fnp-3806	4751	3	a	a	PROPN
fnp-3806	4751	4	,	,	PUNCT
fnp-3806	4751	5	marano	marano	PROPN
fnp-3806	4751	6	n	n	CCONJ
fnp-3806	4751	7	,	,	PUNCT
fnp-3806	4751	8	gliozzi	gliozzi	NOUN
fnp-3806	4751	9	a.	a.	NOUN
fnp-3806	4751	10	probing	probe	VERB
fnp-3806	4751	11	the	the	DET
fnp-3806	4751	12	interplay	interplay	NOUN
fnp-3806	4751	13	between	between	ADP
fnp-3806	4751	14	amyloidogenic	amyloidogenic	ADJ
fnp-3806	4751	15	proteins	protein	NOUN
fnp-3806	4751	16	and	and	CCONJ
fnp-3806	4751	17	membranes	membrane	NOUN
fnp-3806	4751	18	using	use	VERB
fnp-3806	4751	19	lipid	lipid	ADJ
fnp-3806	4751	20	monolayers	monolayer	NOUN
fnp-3806	4751	21	and	and	CCONJ
fnp-3806	4751	22	bilayers	bilayer	NOUN
fnp-3806	4751	23	.	.	PUNCT
fnp-3806	4752	1	adv	adv	PROPN
fnp-3806	4752	2	colloid	colloid	PROPN
fnp-3806	4752	3	interface	interface	NOUN
fnp-3806	4752	4	sci	sci	PROPN
fnp-3806	4752	5	2014;207:81	2014;207:81	NUM
fnp-3806	4752	6	-	-	SYM
fnp-3806	4752	7	92	92	NUM
fnp-3806	4752	8	.	.	PUNCT
fnp-3806	4753	1	https://doi.org/10.1016/j.cis.2013.10.015	https://doi.org/10.1016/j.cis.2013.10.015	NOUN
fnp-3806	4753	2	georgieva	georgieva	PROPN
fnp-3806	4753	3	er	er	INTJ
fnp-3806	4753	4	,	,	PUNCT
fnp-3806	4753	5	xiao	xiao	PROPN
fnp-3806	4753	6	s	s	PROPN
fnp-3806	4753	7	,	,	PUNCT
fnp-3806	4753	8	borbat	borbat	NOUN
fnp-3806	4753	9	pp	pp	ADV
fnp-3806	4753	10	,	,	PUNCT
fnp-3806	4753	11	et	et	PROPN
fnp-3806	4753	12	al	al	PROPN
fnp-3806	4753	13	.	.	PUNCT
fnp-3806	4754	1	tau	tau	PROPN
fnp-3806	4754	2	binds	bind	VERB
fnp-3806	4754	3	to	to	ADP
fnp-3806	4754	4	lipid	lipid	ADJ
fnp-3806	4754	5	membrane	membrane	NOUN
fnp-3806	4754	6	surfaces	surface	NOUN
fnp-3806	4754	7	via	via	ADP
fnp-3806	4754	8	short	short	ADJ
fnp-3806	4754	9	amphipathic	amphipathic	ADJ
fnp-3806	4754	10	helices	helix	NOUN
fnp-3806	4754	11	located	locate	VERB
fnp-3806	4754	12	in	in	ADP
fnp-3806	4754	13	its	its	PRON
fnp-3806	4754	14	microtubule	microtubule	NOUN
fnp-3806	4754	15	-	-	PUNCT
fnp-3806	4754	16	binding	bind	VERB
fnp-3806	4754	17	repeats	repeat	NOUN
fnp-3806	4754	18	.	.	PUNCT
fnp-3806	4755	1	biophys	biophy	NOUN
fnp-3806	4755	2	j	j	PROPN
fnp-3806	4755	3	2014;107:1441	2014;107:1441	NUM
fnp-3806	4755	4	-	-	SYM
fnp-3806	4755	5	1452	1452	NUM
fnp-3806	4755	6	.	.	PUNCT
fnp-3806	4756	1	https://doi.org/10.1016/j.bpj.2014.07.046	https://doi.org/10.1016/j.bpj.2014.07.046	AUX
fnp-3806	4756	2	majewski	majewski	VERB
fnp-3806	4756	3	j	j	PROPN
fnp-3806	4756	4	,	,	PUNCT
fnp-3806	4756	5	jones	jones	PROPN
fnp-3806	4756	6	em	em	PRON
fnp-3806	4756	7	,	,	PUNCT
fnp-3806	4756	8	vander	vander	PROPN
fnp-3806	4756	9	zanden	zanden	PROPN
fnp-3806	4756	10	cm	cm	PROPN
fnp-3806	4756	11	,	,	PUNCT
fnp-3806	4756	12	et	et	PROPN
fnp-3806	4756	13	al	al	PROPN
fnp-3806	4756	14	.	.	PROPN
fnp-3806	4756	15	lipid	lipid	PROPN
fnp-3806	4756	16	membrane	membrane	NOUN
fnp-3806	4756	17	templated	template	VERB
fnp-3806	4756	18	misfolding	misfolding	NOUN
fnp-3806	4756	19	and	and	CCONJ
fnp-3806	4756	20	self	self	NOUN
fnp-3806	4756	21	-	-	PUNCT
fnp-3806	4756	22	assembly	assembly	NOUN
fnp-3806	4756	23	of	of	ADP
fnp-3806	4756	24	intrinsically	intrinsically	ADV
fnp-3806	4756	25	disordered	disordered	ADJ
fnp-3806	4756	26	tau	tau	PROPN
fnp-3806	4756	27	protein	protein	NOUN
fnp-3806	4756	28	.	.	PUNCT
fnp-3806	4757	1	sci	sci	PROPN
fnp-3806	4757	2	rep	rep	PROPN
fnp-3806	4757	3	2020;10:13324	2020;10:13324	PROPN
fnp-3806	4757	4	.	.	PROPN
fnp-3806	4757	5	https://doi.org/10.1038/s41598-020-70208-6	https://doi.org/10.1038/s41598-020-70208-6	NUM
fnp-3806	4757	6	künze	künze	PROPN
fnp-3806	4757	7	g	g	PROPN
fnp-3806	4757	8	,	,	PUNCT
fnp-3806	4757	9	barré	barré	PROPN
fnp-3806	4757	10	p	p	PROPN
fnp-3806	4757	11	,	,	PUNCT
fnp-3806	4757	12	scheidt	scheidt	PROPN
fnp-3806	4757	13	ha	ha	INTJ
fnp-3806	4757	14	,	,	PUNCT
fnp-3806	4757	15	et	et	PROPN
fnp-3806	4757	16	al	al	PROPN
fnp-3806	4757	17	.	.	PUNCT
fnp-3806	4758	1	binding	bind	VERB
fnp-3806	4758	2	of	of	ADP
fnp-3806	4758	3	the	the	DET
fnp-3806	4758	4	three	three	NUM
fnp-3806	4758	5	-	-	PUNCT
fnp-3806	4758	6	repeat	repeat	NOUN
fnp-3806	4758	7	domain	domain	NOUN
fnp-3806	4758	8	of	of	ADP
fnp-3806	4758	9	tau	tau	PROPN
fnp-3806	4758	10	to	to	ADP
fnp-3806	4758	11	phospholipid	phospholipid	NOUN
fnp-3806	4758	12	membranes	membrane	NOUN
fnp-3806	4758	13	induces	induce	VERB
fnp-3806	4758	14	an	an	DET
fnp-3806	4758	15	aggregated	aggregate	VERB
fnp-3806	4758	16	-	-	PUNCT
fnp-3806	4758	17	like	like	ADJ
fnp-3806	4758	18	state	state	NOUN
fnp-3806	4758	19	of	of	ADP
fnp-3806	4758	20	the	the	DET
fnp-3806	4758	21	protein	protein	NOUN
fnp-3806	4758	22	.	.	PUNCT
fnp-3806	4759	1	biochim	biochim	PROPN
fnp-3806	4759	2	biophys	biophy	NOUN
fnp-3806	4759	3	acta	acta	PROPN
fnp-3806	4759	4	biomembr	biomembr	NOUN
fnp-3806	4759	5	2012	2012	NUM
fnp-3806	4759	6	;	;	PUNCT
fnp-3806	4759	7	1818	1818	NUM
fnp-3806	4759	8	:	:	PUNCT
fnp-3806	4760	1	2302–2313	2302–2313	NUM
fnp-3806	4760	2	.	.	PUNCT
fnp-3806	4761	1	https://doi.org/10.1016/j.bbamem.2012.03.019	https://doi.org/10.1016/j.bbamem.2012.03.019	NUM
fnp-3806	4761	2	elbaum	elbaum	NOUN
fnp-3806	4761	3	-	-	PUNCT
fnp-3806	4761	4	garfinkle	garfinkle	NOUN
fnp-3806	4761	5	s	s	NOUN
fnp-3806	4761	6	,	,	PUNCT
fnp-3806	4761	7	ramlall	ramlall	PROPN
fnp-3806	4761	8	t	t	PROPN
fnp-3806	4761	9	,	,	PUNCT
fnp-3806	4761	10	rhoades	rhoade	VERB
fnp-3806	4761	11	e.	e.	PROPN
fnp-3806	4762	1	the	the	DET
fnp-3806	4762	2	role	role	NOUN
fnp-3806	4762	3	of	of	ADP
fnp-3806	4762	4	the	the	DET
fnp-3806	4762	5	lipid	lipid	NOUN
fnp-3806	4762	6	bilayer	bilayer	NOUN
fnp-3806	4762	7	in	in	ADP
fnp-3806	4762	8	tau	tau	PROPN
fnp-3806	4762	9	aggregation	aggregation	NOUN
fnp-3806	4762	10	.	.	PUNCT
fnp-3806	4763	1	biophys	biophys	PROPN
fnp-3806	4763	2	j	j	PROPN
fnp-3806	4763	3	2010	2010	NUM
fnp-3806	4763	4	;	;	PUNCT
fnp-3806	4763	5	98	98	NUM
fnp-3806	4763	6	:	:	SYM
fnp-3806	4763	7	2722	2722	NUM
fnp-3806	4763	8	-	-	SYM
fnp-3806	4763	9	2730	2730	NUM
fnp-3806	4763	10	.	.	PUNCT
fnp-3806	4764	1	https://doi.org/10.1016/j.bpj.2010.03.013	https://doi.org/10.1016/j.bpj.2010.03.013	PROPN
fnp-3806	4764	2	chad	chad	VERB
fnp-3806	4764	3	a	a	DET
fnp-3806	4764	4	sallaberry	sallaberry	NOUN
fnp-3806	4764	5	ca	ca	PROPN
fnp-3806	4764	6	,	,	PUNCT
fnp-3806	4764	7	voss	voss	PROPN
fnp-3806	4764	8	bj	bj	PROPN
fnp-3806	4764	9	,	,	PUNCT
fnp-3806	4764	10	et	et	PROPN
fnp-3806	4764	11	al	al	PROPN
fnp-3806	4764	12	.	.	PUNCT
fnp-3806	4765	1	tau	tau	PROPN
fnp-3806	4765	2	and	and	CCONJ
fnp-3806	4765	3	membranes	membrane	NOUN
fnp-3806	4765	4	:	:	PUNCT
fnp-3806	4765	5	interactions	interaction	NOUN
fnp-3806	4765	6	that	that	PRON
fnp-3806	4765	7	promote	promote	VERB
fnp-3806	4765	8	folding	folding	NOUN
fnp-3806	4765	9	and	and	CCONJ
fnp-3806	4765	10	condensation	condensation	NOUN
fnp-3806	4765	11	.	.	PUNCT
fnp-3806	4766	1	front	front	ADJ
fnp-3806	4766	2	cell	cell	NOUN
fnp-3806	4766	3	dev	dev	PROPN
fnp-3806	4766	4	biol	biol	PROPN
fnp-3806	4766	5	2021;9:725241	2021;9:725241	NUM
fnp-3806	4766	6	.	.	PUNCT
fnp-3806	4767	1	https://doi.org/10.3389/fcell.2021.725241	https://doi.org/10.3389/fcell.2021.725241	PROPN
fnp-3806	4767	2	ferrer	ferrer	PROPN
fnp-3806	4767	3	i	i	PROPN
fnp-3806	4767	4	,	,	PUNCT
fnp-3806	4767	5	andrés	andrés	PROPN
fnp-3806	4767	6	-	-	PUNCT
fnp-3806	4767	7	benito	benito	PROPN
fnp-3806	4767	8	p	p	PROPN
fnp-3806	4767	9	,	,	PUNCT
fnp-3806	4767	10	ausín	ausín	PROPN
fnp-3806	4767	11	k	k	PROPN
fnp-3806	4767	12	,	,	PUNCT
fnp-3806	4767	13	et	et	PROPN
fnp-3806	4767	14	al	al	PROPN
fnp-3806	4767	15	.	.	PROPN
fnp-3806	4767	16	dysregulated	dysregulate	VERB
fnp-3806	4767	17	protein	protein	NOUN
fnp-3806	4767	18	phosphorylation	phosphorylation	NOUN
fnp-3806	4767	19	:	:	PUNCT
fnp-3806	4767	20	a	a	DET
fnp-3806	4767	21	determining	determine	VERB
fnp-3806	4767	22	condition	condition	NOUN
fnp-3806	4767	23	in	in	ADP
fnp-3806	4767	24	the	the	DET
fnp-3806	4767	25	continuum	continuum	NOUN
fnp-3806	4767	26	of	of	ADP
fnp-3806	4767	27	brain	brain	NOUN
fnp-3806	4767	28	aging	aging	NOUN
fnp-3806	4767	29	and	and	CCONJ
fnp-3806	4767	30	alzheimer	alzheimer	PROPN
fnp-3806	4767	31	’s	’s	PART
fnp-3806	4767	32	disease	disease	NOUN
fnp-3806	4767	33	.	.	PUNCT
fnp-3806	4768	1	brain	brain	NOUN
fnp-3806	4768	2	pathol	pathol	NOUN
fnp-3806	4768	3	2021	2021	NUM
fnp-3806	4768	4	;	;	PUNCT
fnp-3806	4768	5	31	31	NUM
fnp-3806	4768	6	:	:	PUNCT
fnp-3806	4768	7	e12996	e12996	VERB
fnp-3806	4768	8	.	.	PUNCT
fnp-3806	4769	1	https://doi.org/10.1111/bpa.12996	https://doi.org/10.1111/bpa.12996	PROPN
fnp-3806	4769	2	quest	quest	PROPN
fnp-3806	4769	3	af	af	PROPN
fnp-3806	4769	4	,	,	PUNCT
fnp-3806	4769	5	leyton	leyton	PROPN
fnp-3806	4769	6	l	l	NOUN
fnp-3806	4769	7	,	,	PUNCT
fnp-3806	4769	8	párraga	párraga	NOUN
fnp-3806	4769	9	m.	m.	NOUN
fnp-3806	4769	10	caveolins	caveolin	NOUN
fnp-3806	4769	11	,	,	PUNCT
fnp-3806	4769	12	caveolae	caveolae	NOUN
fnp-3806	4769	13	,	,	PUNCT
fnp-3806	4769	14	and	and	CCONJ
fnp-3806	4769	15	lipid	lipid	NOUN
fnp-3806	4769	16	rafts	raft	NOUN
fnp-3806	4769	17	in	in	ADP
fnp-3806	4769	18	cellular	cellular	ADJ
fnp-3806	4769	19	transport	transport	NOUN
fnp-3806	4769	20	,	,	PUNCT
fnp-3806	4769	21	signaling	signaling	ADJ
fnp-3806	4769	22	,	,	PUNCT
fnp-3806	4769	23	and	and	CCONJ
fnp-3806	4769	24	disease	disease	NOUN
fnp-3806	4769	25	.	.	PUNCT
fnp-3806	4770	1	biochem	biochem	PROPN
fnp-3806	4770	2	cell	cell	NOUN
fnp-3806	4770	3	biol	biol	PROPN
fnp-3806	4770	4	2004;82:129	2004;82:129	PROPN
fnp-3806	4770	5	-	-	SYM
fnp-3806	4770	6	144	144	NUM
fnp-3806	4770	7	.	.	PUNCT
fnp-3806	4771	1	https://doi.org/10.1139/o03-071	https://doi.org/10.1139/o03-071	PROPN
fnp-3806	4772	1	van	van	PROPN
fnp-3806	4772	2	helmond	helmond	PROPN
fnp-3806	4772	3	zk	zk	PROPN
fnp-3806	4772	4	,	,	PUNCT
fnp-3806	4772	5	scott	scott	PROPN
fnp-3806	4772	6	miners	miners	PROPN
fnp-3806	4772	7	j	j	PROPN
fnp-3806	4772	8	,	,	PUNCT
fnp-3806	4772	9	bednall	bednall	ADV
fnp-3806	4772	10	e	e	PROPN
fnp-3806	4772	11	,	,	PUNCT
fnp-3806	4772	12	et	et	PROPN
fnp-3806	4772	13	al	al	PROPN
fnp-3806	4772	14	.	.	PROPN
fnp-3806	4772	15	caveolin-1	caveolin-1	NUM
fnp-3806	4773	1	and	and	CCONJ
fnp-3806	4773	2	-2	-2	NOUN
fnp-3806	4773	3	and	and	CCONJ
fnp-3806	4773	4	their	their	PRON
fnp-3806	4773	5	relationship	relationship	NOUN
fnp-3806	4773	6	to	to	ADP
fnp-3806	4773	7	cerebral	cerebral	ADJ
fnp-3806	4773	8	amyloid	amyloid	NOUN
fnp-3806	4773	9	angiopathy	angiopathy	NOUN
fnp-3806	4773	10	in	in	ADP
fnp-3806	4773	11	alzheimer	alzheimer	PROPN
fnp-3806	4773	12	's	's	PART
fnp-3806	4773	13	disease	disease	NOUN
fnp-3806	4773	14	.	.	PUNCT
fnp-3806	4774	1	neuropathol	neuropathol	PROPN
fnp-3806	4774	2	appl	appl	PROPN
fnp-3806	4774	3	neurobiol	neurobiol	PROPN
fnp-3806	4774	4	2007;33:317	2007;33:317	PROPN
fnp-3806	4774	5	-	-	SYM
fnp-3806	4774	6	327	327	NUM
fnp-3806	4774	7	.	.	PUNCT
fnp-3806	4775	1	https://doi.org/10.1111/j.1365-2990.2006.00815.x	https://doi.org/10.1111/j.1365-2990.2006.00815.x	ADJ
fnp-3806	4775	2	ramírez	ramírez	PROPN
fnp-3806	4775	3	cm	cm	PROPN
fnp-3806	4775	4	,	,	PUNCT
fnp-3806	4775	5	gonzález	gonzález	PROPN
fnp-3806	4775	6	m	m	PROPN
fnp-3806	4775	7	,	,	PUNCT
fnp-3806	4775	8	díaz	díaz	PROPN
fnp-3806	4775	9	m	m	PROPN
fnp-3806	4775	10	,	,	PUNCT
fnp-3806	4776	1	et	et	PROPN
fnp-3806	4776	2	al	al	PROPN
fnp-3806	4776	3	.	.	PROPN
fnp-3806	4776	4	vdac	vdac	PROPN
fnp-3806	4776	5	and	and	CCONJ
fnp-3806	4776	6	eralpha	eralpha	NOUN
fnp-3806	4776	7	interaction	interaction	NOUN
fnp-3806	4776	8	in	in	ADP
fnp-3806	4776	9	caveolae	caveolae	NOUN
fnp-3806	4776	10	from	from	ADP
fnp-3806	4776	11	human	human	ADJ
fnp-3806	4776	12	cortex	cortex	NOUN
fnp-3806	4776	13	is	be	AUX
fnp-3806	4776	14	altered	alter	VERB
fnp-3806	4776	15	in	in	ADP
fnp-3806	4776	16	alzheimer	alzheimer	PROPN
fnp-3806	4776	17	's	's	PART
fnp-3806	4776	18	disease	disease	NOUN
fnp-3806	4776	19	.	.	PUNCT
fnp-3806	4777	1	mol	mol	ADP
fnp-3806	4777	2	cell	cell	NOUN
fnp-3806	4777	3	neurosci	neurosci	NOUN
fnp-3806	4777	4	2009;42:172	2009;42:172	NOUN
fnp-3806	4777	5	-	-	SYM
fnp-3806	4777	6	183	183	NUM
fnp-3806	4777	7	.	.	PUNCT
fnp-3806	4778	1	https://doi.org/10.1016/j.mcn.2009.07.001	https://doi.org/10.1016/j.mcn.2009.07.001	ADJ
fnp-3806	4778	2	puangmalai	puangmalai	NOUN
fnp-3806	4778	3	n	n	CCONJ
fnp-3806	4778	4	,	,	PUNCT
fnp-3806	4778	5	bhatt	bhatt	PROPN
fnp-3806	4778	6	n	n	CCONJ
fnp-3806	4778	7	,	,	PUNCT
fnp-3806	4778	8	montalbano	montalbano	VERB
fnp-3806	4778	9	m	m	PROPN
fnp-3806	4778	10	,	,	PUNCT
fnp-3806	4778	11	et	et	PROPN
fnp-3806	4778	12	al	al	PROPN
fnp-3806	4778	13	.	.	PUNCT
fnp-3806	4778	14	internalization	internalization	NOUN
fnp-3806	4778	15	mechanisms	mechanism	NOUN
fnp-3806	4778	16	of	of	ADP
fnp-3806	4778	17	brain	brain	NOUN
fnp-3806	4778	18	-	-	PUNCT
fnp-3806	4778	19	derived	derive	VERB
fnp-3806	4778	20	tau	tau	NOUN
fnp-3806	4778	21	oligomers	oligomer	NOUN
fnp-3806	4778	22	from	from	ADP
fnp-3806	4778	23	patients	patient	NOUN
fnp-3806	4778	24	with	with	ADP
fnp-3806	4778	25	alzheimer	alzheimer	PROPN
fnp-3806	4778	26	's	's	PART
fnp-3806	4778	27	disease	disease	NOUN
fnp-3806	4778	28	,	,	PUNCT
fnp-3806	4778	29	progressive	progressive	ADJ
fnp-3806	4778	30	supranuclear	supranuclear	ADJ
fnp-3806	4778	31	palsy	palsy	ADJ
fnp-3806	4778	32	and	and	CCONJ
fnp-3806	4778	33	dementia	dementia	NOUN
fnp-3806	4778	34	with	with	ADP
fnp-3806	4778	35	lewy	lewy	PROPN
fnp-3806	4778	36	bodies	body	NOUN
fnp-3806	4778	37	.	.	PUNCT
fnp-3806	4779	1	cell	cell	NOUN
fnp-3806	4779	2	death	death	NOUN
fnp-3806	4779	3	dis	dis	PROPN
fnp-3806	4779	4	2020;11:314	2020;11:314	NUM
fnp-3806	4779	5	.	.	PUNCT
fnp-3806	4780	1	https://doi.org/10.1038/s41419-020-2503-3	https://doi.org/10.1038/s41419-020-2503-3	NUM
fnp-3806	4780	2	de	de	X
fnp-3806	4780	3	groot	groot	X
fnp-3806	4780	4	ns	ns	PROPN
fnp-3806	4780	5	,	,	PUNCT
fnp-3806	4780	6	burgas	burgas	PROPN
fnp-3806	4780	7	mt	mt	PROPN
fnp-3806	4780	8	.	.	PROPN
fnp-3806	4780	9	is	be	AUX
fnp-3806	4780	10	membrane	membrane	NOUN
fnp-3806	4780	11	homeostasis	homeostasis	NOUN
fnp-3806	4780	12	the	the	DET
fnp-3806	4780	13	missing	miss	VERB
fnp-3806	4780	14	link	link	NOUN
fnp-3806	4780	15	between	between	ADP
fnp-3806	4780	16	inflammation	inflammation	NOUN
fnp-3806	4780	17	and	and	CCONJ
fnp-3806	4780	18	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4780	19	diseases	disease	NOUN
fnp-3806	4780	20	?	?	PUNCT
fnp-3806	4781	1	cell	cell	NOUN
fnp-3806	4781	2	mol	mol	ADP
fnp-3806	4781	3	life	life	NOUN
fnp-3806	4781	4	sci	sci	PROPN
fnp-3806	4781	5	2015;72:4795	2015;72:4795	NUM
fnp-3806	4781	6	-	-	PUNCT
fnp-3806	4781	7	805	805	NUM
fnp-3806	4781	8	.	.	PUNCT
fnp-3806	4782	1	https://doi.org/10.1007/s00018-015-2038-4	https://doi.org/10.1007/s00018-015-2038-4	NUM
fnp-3806	4782	2	krigman	krigman	PROPN
fnp-3806	4782	3	mr	mr	PROPN
fnp-3806	4782	4	,	,	PUNCT
fnp-3806	4782	5	feldman	feldman	PROPN
fnp-3806	4782	6	rg	rg	PROPN
fnp-3806	4782	7	,	,	PUNCT
fnp-3806	4782	8	bensch	bensch	PROPN
fnp-3806	4782	9	k.	k.	PROPN
fnp-3806	4782	10	alzheimer	alzheimer	PROPN
fnp-3806	4782	11	’s	’s	PART
fnp-3806	4782	12	presenile	presenile	PROPN
fnp-3806	4782	13	dementia	dementia	PROPN
fnp-3806	4782	14	.	.	PUNCT
fnp-3806	4783	1	a	a	DET
fnp-3806	4783	2	histochemical	histochemical	ADJ
fnp-3806	4783	3	and	and	CCONJ
fnp-3806	4783	4	electron	electron	NOUN
fnp-3806	4783	5	microscopic	microscopic	ADJ
fnp-3806	4783	6	study	study	NOUN
fnp-3806	4783	7	.	.	PUNCT
fnp-3806	4784	1	lab	lab	NOUN
fnp-3806	4784	2	invest	invest	VERB
fnp-3806	4784	3	1965;14:381	1965;14:381	NUM
fnp-3806	4784	4	-	-	SYM
fnp-3806	4784	5	396	396	NUM
fnp-3806	4784	6	.	.	PUNCT
fnp-3806	4785	1	pmid	pmid	NOUN
fnp-3806	4785	2	:	:	PUNCT
fnp-3806	4785	3	14281440	14281440	NUM
fnp-3806	4785	4	.	.	PUNCT
fnp-3806	4786	1	hirai	hirai	PROPN
fnp-3806	4786	2	k	k	PROPN
fnp-3806	4786	3	,	,	PUNCT
fnp-3806	4786	4	aliev	aliev	ADP
fnp-3806	4786	5	g	g	PROPN
fnp-3806	4786	6	,	,	PUNCT
fnp-3806	4786	7	nunomura	nunomura	NOUN
fnp-3806	4786	8	a	a	NOUN
fnp-3806	4786	9	,	,	PUNCT
fnp-3806	4786	10	et	et	PROPN
fnp-3806	4786	11	al	al	PROPN
fnp-3806	4786	12	.	.	PUNCT
fnp-3806	4787	1	mitochondrial	mitochondrial	ADJ
fnp-3806	4787	2	abnormalities	abnormality	NOUN
fnp-3806	4787	3	in	in	ADP
fnp-3806	4787	4	alzheimer	alzheimer	PROPN
fnp-3806	4787	5	's	's	PART
fnp-3806	4787	6	disease	disease	NOUN
fnp-3806	4787	7	.	.	PUNCT
fnp-3806	4788	1	j	j	PROPN
fnp-3806	4788	2	neurosci	neurosci	PROPN
fnp-3806	4788	3	2001;21:3017	2001;21:3017	NUM
fnp-3806	4788	4	-	-	SYM
fnp-3806	4788	5	3023	3023	NUM
fnp-3806	4788	6	.	.	PUNCT
fnp-3806	4789	1	https://doi.org/10.1523/jneurosci.21-09-03017.2001	https://doi.org/10.1523/jneurosci.21-09-03017.2001	PROPN
fnp-3806	4789	2	baloyannis	baloyannis	PROPN
fnp-3806	4789	3	sj	sj	PROPN
fnp-3806	4789	4	.	.	PUNCT
fnp-3806	4789	5	mitochondrial	mitochondrial	ADJ
fnp-3806	4789	6	alterations	alteration	NOUN
fnp-3806	4789	7	in	in	ADP
fnp-3806	4789	8	alzheimer	alzheimer	PROPN
fnp-3806	4789	9	’s	’s	PART
fnp-3806	4789	10	disease	disease	NOUN
fnp-3806	4789	11	.	.	PUNCT
fnp-3806	4790	1	j	j	PROPN
fnp-3806	4790	2	alzheimer	alzheimer	PROPN
fnp-3806	4790	3	’s	’s	PART
fnp-3806	4790	4	dis	dis	PROPN
fnp-3806	4790	5	2006	2006	NUM
fnp-3806	4790	6	;	;	PUNCT
fnp-3806	4790	7	9:119	9:119	NUM
fnp-3806	4790	8	-	-	SYM
fnp-3806	4790	9	126	126	NUM
fnp-3806	4790	10	.	.	PUNCT
fnp-3806	4791	1	https://doi.org/10.3233/jad-2006-9204	https://doi.org/10.3233/jad-2006-9204	PROPN
fnp-3806	4791	2	chen	chen	PROPN
fnp-3806	4791	3	jx	jx	PROPN
fnp-3806	4791	4	,	,	PUNCT
fnp-3806	4791	5	yan	yan	PROPN
fnp-3806	4791	6	ss	ss	PROPN
fnp-3806	4791	7	.	.	PUNCT
fnp-3806	4791	8	role	role	NOUN
fnp-3806	4791	9	of	of	ADP
fnp-3806	4791	10	mitochondrial	mitochondrial	ADJ
fnp-3806	4791	11	amyloid	amyloid	NOUN
fnp-3806	4791	12	-	-	PUNCT
fnp-3806	4791	13	beta	beta	NOUN
fnp-3806	4791	14	in	in	ADP
fnp-3806	4791	15	alzheimer	alzheimer	PROPN
fnp-3806	4791	16	’s	’s	PART
fnp-3806	4791	17	disease	disease	NOUN
fnp-3806	4791	18	.	.	PUNCT
fnp-3806	4792	1	j	j	PROPN
fnp-3806	4792	2	alzheimers	alzheimers	PROPN
fnp-3806	4792	3	dis	dis	PROPN
fnp-3806	4792	4	2010	2010	NUM
fnp-3806	4792	5	;	;	PUNCT
fnp-3806	4792	6	20	20	NUM
fnp-3806	4792	7	:	:	SYM
fnp-3806	4792	8	20	20	NUM
fnp-3806	4792	9	:	:	PUNCT
fnp-3806	4792	10	s569	s569	PROPN
fnp-3806	4792	11	-	-	PUNCT
fnp-3806	4792	12	578	578	NUM
fnp-3806	4792	13	.	.	PUNCT
fnp-3806	4793	1	https://doi.org/10.3233/jad-2010-100357	https://doi.org/10.3233/jad-2010-100357	PROPN
fnp-3806	4793	2	cheng	cheng	PROPN
fnp-3806	4793	3	y	y	PROPN
fnp-3806	4793	4	,	,	PUNCT
fnp-3806	4793	5	bai	bai	PROPN
fnp-3806	4793	6	f.	f.	PROPN
fnp-3806	4793	7	the	the	DET
fnp-3806	4793	8	association	association	PROPN
fnp-3806	4793	9	of	of	ADP
fnp-3806	4793	10	tau	tau	PROPN
fnp-3806	4793	11	with	with	ADP
fnp-3806	4793	12	mitochondrial	mitochondrial	ADJ
fnp-3806	4793	13	dysfunction	dysfunction	NOUN
fnp-3806	4793	14	in	in	ADP
fnp-3806	4793	15	alzheimer	alzheimer	PROPN
fnp-3806	4793	16	’s	’s	PART
fnp-3806	4793	17	disease	disease	NOUN
fnp-3806	4793	18	.	.	PUNCT
fnp-3806	4794	1	front	front	ADJ
fnp-3806	4794	2	neurosci	neurosci	PROPN
fnp-3806	4794	3	2018;12:163	2018;12:163	NUM
fnp-3806	4794	4	.	.	PUNCT
fnp-3806	4795	1	https://doi.org/10.3389/fnins.2018.00163	https://doi.org/10.3389/fnins.2018.00163	PROPN
fnp-3806	4795	2	swerdlow	swerdlow	PROPN
fnp-3806	4795	3	rh	rh	PROPN
fnp-3806	4795	4	,	,	PUNCT
fnp-3806	4795	5	khan	khan	PROPN
fnp-3806	4795	6	sm	sm	PROPN
fnp-3806	4795	7	.	.	PUNCT
fnp-3806	4796	1	a	a	DET
fnp-3806	4796	2	“	"	PUNCT
fnp-3806	4796	3	mitochondrial	mitochondrial	ADJ
fnp-3806	4796	4	cascade	cascade	NOUN
fnp-3806	4796	5	hypothesis	hypothesis	NOUN
fnp-3806	4796	6	”	"	PUNCT
fnp-3806	4796	7	for	for	ADP
fnp-3806	4796	8	sporadic	sporadic	ADJ
fnp-3806	4796	9	alzheimer	alzheimer	PROPN
fnp-3806	4796	10	’s	’s	PART
fnp-3806	4796	11	disease	disease	NOUN
fnp-3806	4796	12	.	.	PUNCT
fnp-3806	4797	1	med	med	ADJ
fnp-3806	4797	2	hypotheses	hypothesis	NOUN
fnp-3806	4797	3	2004	2004	NUM
fnp-3806	4797	4	;	;	PUNCT
fnp-3806	4797	5	63:8	63:8	PROPN
fnp-3806	4797	6	-	-	SYM
fnp-3806	4797	7	20	20	NUM
fnp-3806	4797	8	.	.	PUNCT
fnp-3806	4798	1	https://doi.org/10.1016/j.mehy.2003.12.045	https://doi.org/10.1016/j.mehy.2003.12.045	ADJ
fnp-3806	4798	2	swerdlow	swerdlow	NOUN
fnp-3806	4798	3	rh	rh	PROPN
fnp-3806	4798	4	.	.	PROPN
fnp-3806	4798	5	mitochondria	mitochondria	PROPN
fnp-3806	4798	6	and	and	CCONJ
fnp-3806	4798	7	mitochondrial	mitochondrial	ADJ
fnp-3806	4798	8	cascades	cascade	NOUN
fnp-3806	4798	9	in	in	ADP
fnp-3806	4798	10	alzheimer	alzheimer	PROPN
fnp-3806	4798	11	’s	’s	PART
fnp-3806	4798	12	disease	disease	NOUN
fnp-3806	4798	13	.	.	PUNCT
fnp-3806	4799	1	j	j	PROPN
fnp-3806	4799	2	alzheimers	alzheimers	PROPN
fnp-3806	4799	3	dis	dis	PROPN
fnp-3806	4799	4	2018	2018	NUM
fnp-3806	4799	5	;	;	PUNCT
fnp-3806	4799	6	62:1403	62:1403	NOUN
fnp-3806	4799	7	-	-	SYM
fnp-3806	4799	8	1416	1416	NUM
fnp-3806	4799	9	.	.	PUNCT
fnp-3806	4800	1	https://doi.org/10.3233/jad-170585	https://doi.org/10.3233/jad-170585	PRON
fnp-3806	4800	2	hauptmann	hauptmann	PROPN
fnp-3806	4800	3	s	s	PART
fnp-3806	4800	4	,	,	PUNCT
fnp-3806	4800	5	keil	keil	PROPN
fnp-3806	4800	6	u	u	NOUN
fnp-3806	4800	7	,	,	PUNCT
fnp-3806	4800	8	scherping	scherpe	VERB
fnp-3806	4800	9	i	i	PRON
fnp-3806	4800	10	,	,	PUNCT
fnp-3806	4800	11	et	et	PROPN
fnp-3806	4800	12	al	al	PROPN
fnp-3806	4800	13	.	.	PUNCT
fnp-3806	4801	1	mitochondrial	mitochondrial	ADJ
fnp-3806	4801	2	dysfunction	dysfunction	NOUN
fnp-3806	4801	3	in	in	ADP
fnp-3806	4801	4	sporadic	sporadic	ADJ
fnp-3806	4801	5	and	and	CCONJ
fnp-3806	4801	6	genetic	genetic	ADJ
fnp-3806	4801	7	alzheimer	alzheimer	NOUN
fnp-3806	4801	8	's	's	PART
fnp-3806	4801	9	disease	disease	NOUN
fnp-3806	4801	10	.	.	PUNCT
fnp-3806	4802	1	exp	exp	NOUN
fnp-3806	4802	2	gerontol	gerontol	PROPN
fnp-3806	4802	3	2006;41:668	2006;41:668	PROPN
fnp-3806	4802	4	-	-	PUNCT
fnp-3806	4802	5	673	673	NUM
fnp-3806	4802	6	.	.	PUNCT
fnp-3806	4803	1	https://doi.org/10.1016/j.exger.2006.03.012	https://doi.org/10.1016/j.exger.2006.03.012	PROPN
fnp-3806	4803	2	grimm	grimm	PROPN
fnp-3806	4803	3	a	a	PROPN
fnp-3806	4803	4	,	,	PUNCT
fnp-3806	4803	5	friedland	friedland	PROPN
fnp-3806	4803	6	k	k	PROPN
fnp-3806	4803	7	,	,	PUNCT
fnp-3806	4803	8	eckert	eckert	PROPN
fnp-3806	4803	9	a.	a.	PROPN
fnp-3806	4803	10	mitochondrial	mitochondrial	ADJ
fnp-3806	4803	11	dysfunction	dysfunction	NOUN
fnp-3806	4803	12	:	:	PUNCT
fnp-3806	4803	13	the	the	DET
fnp-3806	4803	14	missing	miss	VERB
fnp-3806	4803	15	link	link	NOUN
fnp-3806	4803	16	between	between	ADP
fnp-3806	4803	17	aging	age	VERB
fnp-3806	4803	18	and	and	CCONJ
fnp-3806	4803	19	sporadic	sporadic	ADJ
fnp-3806	4803	20	alzheimer	alzheimer	PROPN
fnp-3806	4803	21	's	's	PART
fnp-3806	4803	22	disease	disease	NOUN
fnp-3806	4803	23	.	.	PUNCT
fnp-3806	4804	1	biogerontology	biogerontology	NOUN
fnp-3806	4804	2	2016;17:281	2016;17:281	PROPN
fnp-3806	4804	3	-	-	PUNCT
fnp-3806	4804	4	296	296	NUM
fnp-3806	4804	5	.	.	PUNCT
fnp-3806	4805	1	https://doi.org/10.1007/s10522-015-9618-4	https://doi.org/10.1007/s10522-015-9618-4	PROPN
fnp-3806	4805	2	wang	wang	PROPN
fnp-3806	4805	3	w	w	PROPN
fnp-3806	4805	4	,	,	PUNCT
fnp-3806	4805	5	zhao	zhao	PROPN
fnp-3806	4805	6	f	f	PROPN
fnp-3806	4805	7	,	,	PUNCT
fnp-3806	4805	8	ma	ma	PROPN
fnp-3806	4805	9	x	x	PROPN
fnp-3806	4805	10	,	,	PUNCT
fnp-3806	4805	11	perry	perry	PROPN
fnp-3806	4805	12	g	g	PROPN
fnp-3806	4805	13	,	,	PUNCT
fnp-3806	4805	14	zhu	zhu	PROPN
fnp-3806	4805	15	x.	x.	NOUN
fnp-3806	4805	16	mitochondria	mitochondria	PROPN
fnp-3806	4805	17	dysfunction	dysfunction	NOUN
fnp-3806	4805	18	in	in	ADP
fnp-3806	4805	19	the	the	DET
fnp-3806	4805	20	pathogenesis	pathogenesis	NOUN
fnp-3806	4805	21	of	of	ADP
fnp-3806	4805	22	alzheimer	alzheimer	PROPN
fnp-3806	4805	23	’s	’s	PART
fnp-3806	4805	24	disease	disease	NOUN
fnp-3806	4805	25	:	:	PUNCT
fnp-3806	4805	26	recent	recent	ADJ
fnp-3806	4805	27	advances	advance	NOUN
fnp-3806	4805	28	.	.	PUNCT
fnp-3806	4806	1	mol	mol	ADP
fnp-3806	4806	2	neurodegener	neurodegener	NOUN
fnp-3806	4806	3	2020;15:30	2020;15:30	NUM
fnp-3806	4806	4	.	.	PUNCT
fnp-3806	4807	1	https://doi.org/10.1186/s13024-020-00376-6	https://doi.org/10.1186/s13024-020-00376-6	VERB
fnp-3806	4807	2	banks	banks	PROPN
fnp-3806	4807	3	b	b	PROPN
fnp-3806	4807	4	,	,	PUNCT
fnp-3806	4807	5	ingram	ingram	PROPN
fnp-3806	4807	6	tl	tl	PROPN
fnp-3806	4807	7	,	,	PUNCT
fnp-3806	4807	8	chakrabarti	chakrabarti	PROPN
fnp-3806	4807	9	l.	l.	PROPN
fnp-3806	4807	10	atp	atp	PROPN
fnp-3806	4807	11	synthase	synthase	NOUN
fnp-3806	4807	12	and	and	CCONJ
fnp-3806	4807	13	alzheimer	alzheimer	PROPN
fnp-3806	4807	14	's	's	PART
fnp-3806	4807	15	disease	disease	NOUN
fnp-3806	4807	16	:	:	PUNCT
fnp-3806	4807	17	putting	put	VERB
fnp-3806	4807	18	a	a	DET
fnp-3806	4807	19	spin	spin	NOUN
fnp-3806	4807	20	on	on	ADP
fnp-3806	4807	21	the	the	DET
fnp-3806	4807	22	mitochondrial	mitochondrial	ADJ
fnp-3806	4807	23	hypothesis	hypothesis	NOUN
fnp-3806	4807	24	aging	age	VERB
fnp-3806	4807	25	(	(	PUNCT
fnp-3806	4807	26	albany	albany	PROPN
fnp-3806	4807	27	ny	ny	PROPN
fnp-3806	4807	28	)	)	PUNCT
fnp-3806	4807	29	2020;12:16647	2020;12:16647	NUM
fnp-3806	4807	30	-	-	SYM
fnp-3806	4807	31	16662	16662	NUM
fnp-3806	4807	32	.	.	PUNCT
fnp-3806	4808	1	https://doi.org/10.18632/aging.103867	https://doi.org/10.18632/aging.103867	PRON
fnp-3806	4808	2	terada	terada	PROPN
fnp-3806	4808	3	t	t	PROPN
fnp-3806	4808	4	,	,	PUNCT
fnp-3806	4808	5	therriault	therriault	NOUN
fnp-3806	4808	6	j	j	PROPN
fnp-3806	4808	7	,	,	PUNCT
fnp-3806	4808	8	kang	kang	PROPN
fnp-3806	4808	9	msp	msp	PROPN
fnp-3806	4808	10	,	,	PUNCT
fnp-3806	4808	11	et	et	PROPN
fnp-3806	4808	12	al	al	PROPN
fnp-3806	4808	13	.	.	PUNCT
fnp-3806	4809	1	mitochondrial	mitochondrial	ADJ
fnp-3806	4809	2	complex	complex	NOUN
fnp-3806	4809	3	i	i	PRON
fnp-3806	4809	4	abnormalities	abnormality	NOUN
fnp-3806	4809	5	is	be	AUX
fnp-3806	4809	6	associated	associate	VERB
fnp-3806	4809	7	with	with	ADP
fnp-3806	4809	8	tau	tau	PROPN
fnp-3806	4809	9	and	and	CCONJ
fnp-3806	4809	10	clinical	clinical	ADJ
fnp-3806	4809	11	symptoms	symptom	NOUN
fnp-3806	4809	12	in	in	ADP
fnp-3806	4809	13	mild	mild	ADJ
fnp-3806	4809	14	alzheimer	alzheimer	NOUN
fnp-3806	4809	15	's	's	PART
fnp-3806	4809	16	disease	disease	NOUN
fnp-3806	4809	17	.	.	PUNCT
fnp-3806	4810	1	mol	mol	ADP
fnp-3806	4810	2	neurodegener	neurodegener	PROPN
fnp-3806	4810	3	2021;16:28	2021;16:28	PROPN
fnp-3806	4810	4	.	.	PUNCT
fnp-3806	4811	1	https://doi.org/10.1186/s13024-021-00448-1	https://doi.org/10.1186/s13024-021-00448-1	PROPN
fnp-3806	4811	2	kawamata	kawamata	PROPN
fnp-3806	4811	3	h	h	PROPN
fnp-3806	4811	4	,	,	PUNCT
fnp-3806	4811	5	manfredi	manfredi	PROPN
fnp-3806	4811	6	g.	g.	PROPN
fnp-3806	4811	7	proteinopathies	proteinopathies	PROPN
fnp-3806	4811	8	and	and	CCONJ
fnp-3806	4811	9	oxphos	oxphos	ADJ
fnp-3806	4811	10	dysfunction	dysfunction	NOUN
fnp-3806	4811	11	in	in	ADP
fnp-3806	4811	12	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4811	13	diseases	disease	NOUN
fnp-3806	4811	14	.	.	PUNCT
fnp-3806	4812	1	j	j	PROPN
fnp-3806	4812	2	cell	cell	NOUN
fnp-3806	4812	3	biol	biol	PROPN
fnp-3806	4812	4	2017;216:3917	2017;216:3917	NUM
fnp-3806	4812	5	-	-	SYM
fnp-3806	4812	6	3929	3929	NUM
fnp-3806	4812	7	.	.	PUNCT
fnp-3806	4813	1	https://doi.org/10.1083/jcb.201709172	https://doi.org/10.1083/jcb.201709172	PROPN
fnp-3806	4813	2	swerdlow	swerdlow	PROPN
fnp-3806	4813	3	rh	rh	PROPN
fnp-3806	4813	4	,	,	PUNCT
fnp-3806	4813	5	burns	burn	VERB
fnp-3806	4813	6	jm	jm	PROPN
fnp-3806	4813	7	,	,	PUNCT
fnp-3806	4813	8	khan	khan	PROPN
fnp-3806	4813	9	sm	sm	PROPN
fnp-3806	4813	10	.	.	PUNCT
fnp-3806	4814	1	the	the	DET
fnp-3806	4814	2	alzheimer	alzheimer	PROPN
fnp-3806	4814	3	’s	’s	PART
fnp-3806	4814	4	disease	disease	NOUN
fnp-3806	4814	5	mitochondrial	mitochondrial	ADJ
fnp-3806	4814	6	cascade	cascade	NOUN
fnp-3806	4814	7	hypothesis	hypothesis	NOUN
fnp-3806	4814	8	:	:	PUNCT
fnp-3806	4814	9	progress	progress	NOUN
fnp-3806	4814	10	and	and	CCONJ
fnp-3806	4814	11	perspectives	perspective	NOUN
fnp-3806	4814	12	.	.	PUNCT
fnp-3806	4815	1	biochim	biochim	PROPN
fnp-3806	4815	2	biophys	biophy	NOUN
fnp-3806	4815	3	acta	acta	PROPN
fnp-3806	4815	4	mol	mol	ADP
fnp-3806	4815	5	basis	basis	NOUN
fnp-3806	4815	6	dis	dis	PROPN
fnp-3806	4815	7	2014	2014	NUM
fnp-3806	4815	8	;	;	PUNCT
fnp-3806	4815	9	1842:1219	1842:1219	NUM
fnp-3806	4815	10	-	-	SYM
fnp-3806	4815	11	1231	1231	NUM
fnp-3806	4815	12	.	.	PUNCT
fnp-3806	4816	1	https://doi.org/10.1016/j.bbadis.2013.09.010	https://doi.org/10.1016/j.bbadis.2013.09.010	PROPN
fnp-3806	4816	2	hoekstra	hoekstra	PROPN
fnp-3806	4816	3	jg	jg	PROPN
fnp-3806	4816	4	,	,	PUNCT
fnp-3806	4816	5	hipp	hipp	PROPN
fnp-3806	4816	6	mj	mj	PROPN
fnp-3806	4816	7	,	,	PUNCT
fnp-3806	4816	8	montine	montine	PROPN
fnp-3806	4816	9	tj	tj	PROPN
fnp-3806	4816	10	,	,	PUNCT
fnp-3806	4816	11	et	et	PROPN
fnp-3806	4816	12	al	al	PROPN
fnp-3806	4816	13	.	.	PROPN
fnp-3806	4816	14	mitochondrial	mitochondrial	ADJ
fnp-3806	4816	15	dna	dna	PROPN
fnp-3806	4816	16	mutations	mutation	NOUN
fnp-3806	4816	17	increase	increase	VERB
fnp-3806	4816	18	in	in	ADP
fnp-3806	4816	19	early	early	ADJ
fnp-3806	4816	20	stage	stage	NOUN
fnp-3806	4816	21	alzheimer	alzheimer	NOUN
fnp-3806	4816	22	disease	disease	NOUN
fnp-3806	4816	23	and	and	CCONJ
fnp-3806	4816	24	are	be	AUX
fnp-3806	4816	25	inconsistent	inconsistent	ADJ
fnp-3806	4816	26	with	with	ADP
fnp-3806	4816	27	oxidative	oxidative	ADJ
fnp-3806	4816	28	damage	damage	NOUN
fnp-3806	4816	29	.	.	PUNCT
fnp-3806	4817	1	ann	ann	PROPN
fnp-3806	4817	2	neurol	neurol	PROPN
fnp-3806	4817	3	2016;80:301	2016;80:301	PROPN
fnp-3806	4817	4	-	-	PUNCT
fnp-3806	4817	5	306	306	NUM
fnp-3806	4817	6	.	.	PUNCT
fnp-3806	4818	1	https://doi.org/10.1002/ana.24709	https://doi.org/10.1002/ana.24709	PROPN
fnp-3806	4818	2	terni	terni	PROPN
fnp-3806	4818	3	b	b	PROPN
fnp-3806	4818	4	,	,	PUNCT
fnp-3806	4818	5	boada	boada	PROPN
fnp-3806	4818	6	j	j	PROPN
fnp-3806	4818	7	,	,	PUNCT
fnp-3806	4818	8	portero	portero	PROPN
fnp-3806	4818	9	-	-	PUNCT
fnp-3806	4818	10	otin	otin	PROPN
fnp-3806	4818	11	m	m	PROPN
fnp-3806	4818	12	,	,	PUNCT
fnp-3806	4818	13	pamplona	pamplona	PROPN
fnp-3806	4818	14	r	r	PROPN
fnp-3806	4818	15	,	,	PUNCT
fnp-3806	4818	16	et	et	PROPN
fnp-3806	4818	17	al	al	PROPN
fnp-3806	4818	18	.	.	PROPN
fnp-3806	4819	1	mitochondrial	mitochondrial	PROPN
fnp-3806	4819	2	atp	atp	NOUN
fnp-3806	4819	3	-	-	PUNCT
fnp-3806	4819	4	synthase	synthase	NOUN
fnp-3806	4819	5	in	in	ADP
fnp-3806	4819	6	the	the	DET
fnp-3806	4819	7	entorhinal	entorhinal	ADJ
fnp-3806	4819	8	cortex	cortex	NOUN
fnp-3806	4819	9	is	be	AUX
fnp-3806	4819	10	a	a	DET
fnp-3806	4819	11	target	target	NOUN
fnp-3806	4819	12	of	of	ADP
fnp-3806	4819	13	oxidative	oxidative	ADJ
fnp-3806	4819	14	stress	stress	NOUN
fnp-3806	4819	15	at	at	ADP
fnp-3806	4819	16	stages	stage	NOUN
fnp-3806	4819	17	i	i	PROPN
fnp-3806	4819	18	/	/	SYM
fnp-3806	4819	19	ii	ii	PROPN
fnp-3806	4819	20	of	of	ADP
fnp-3806	4819	21	alzheimer	alzheimer	PROPN
fnp-3806	4819	22	's	's	PART
fnp-3806	4819	23	disease	disease	NOUN
fnp-3806	4819	24	pathology	pathology	NOUN
fnp-3806	4819	25	.	.	PUNCT
fnp-3806	4820	1	brain	brain	NOUN
fnp-3806	4820	2	pathol	pathol	NOUN
fnp-3806	4820	3	2010;20:222	2010;20:222	NOUN
fnp-3806	4820	4	-	-	NOUN
fnp-3806	4820	5	233	233	NUM
fnp-3806	4820	6	.	.	PUNCT
fnp-3806	4821	1	https://doi.org/10.1111/j.1750-3639.2009.00266.x	https://doi.org/10.1111/j.1750-3639.2009.00266.x	PROPN
fnp-3806	4821	2	busciglio	busciglio	PROPN
fnp-3806	4821	3	j	j	PROPN
fnp-3806	4821	4	,	,	PUNCT
fnp-3806	4821	5	pelsman	pelsman	NOUN
fnp-3806	4821	6	a	a	X
fnp-3806	4821	7	,	,	PUNCT
fnp-3806	4821	8	wong	wong	PROPN
fnp-3806	4821	9	c	c	PROPN
fnp-3806	4821	10	,	,	PUNCT
fnp-3806	4821	11	et	et	PROPN
fnp-3806	4821	12	al	al	PROPN
fnp-3806	4821	13	.	.	PROPN
fnp-3806	4821	14	altered	alter	VERB
fnp-3806	4821	15	metabolism	metabolism	NOUN
fnp-3806	4821	16	of	of	ADP
fnp-3806	4821	17	the	the	DET
fnp-3806	4821	18	amyloid	amyloid	NOUN
fnp-3806	4821	19	precursor	precursor	NOUN
fnp-3806	4821	20	protein	protein	NOUN
fnp-3806	4821	21	is	be	AUX
fnp-3806	4821	22	associated	associate	VERB
fnp-3806	4821	23	with	with	ADP
fnp-3806	4821	24	mitochondrial	mitochondrial	ADJ
fnp-3806	4821	25	dysfunction	dysfunction	NOUN
fnp-3806	4821	26	in	in	ADP
fnp-3806	4821	27	down	down	ADP
fnp-3806	4821	28	’s	’s	PART
fnp-3806	4821	29	syndrome	syndrome	NOUN
fnp-3806	4821	30	.	.	PUNCT
fnp-3806	4822	1	neuron	neuron	PROPN
fnp-3806	4822	2	2002;33	2002;33	NOUN
fnp-3806	4822	3	:	:	PUNCT
fnp-3806	4822	4	677	677	NUM
fnp-3806	4822	5	-	-	SYM
fnp-3806	4822	6	688	688	NUM
fnp-3806	4822	7	.	.	PUNCT
fnp-3806	4823	1	https://doi.org/10.1016/s0896-6273(02)00604-9	https://doi.org/10.1016/s0896-6273(02)00604-9	PROPN
fnp-3806	4823	2	kandimalla	kandimalla	PROPN
fnp-3806	4823	3	r	r	PROPN
fnp-3806	4823	4	,	,	PUNCT
fnp-3806	4823	5	manczak	manczak	NOUN
fnp-3806	4823	6	m	m	PROPN
fnp-3806	4823	7	,	,	PUNCT
fnp-3806	4823	8	yin	yin	PROPN
fnp-3806	4823	9	x	x	X
fnp-3806	4823	10	,	,	PUNCT
fnp-3806	4823	11	et	et	PROPN
fnp-3806	4823	12	al	al	PROPN
fnp-3806	4823	13	.	.	PROPN
fnp-3806	4823	14	hippocampal	hippocampal	PROPN
fnp-3806	4823	15	phosphorylated	phosphorylate	VERB
fnp-3806	4823	16	tau	tau	NOUN
fnp-3806	4823	17	induced	induce	VERB
fnp-3806	4823	18	cognitive	cognitive	ADJ
fnp-3806	4823	19	decline	decline	NOUN
fnp-3806	4823	20	,	,	PUNCT
fnp-3806	4823	21	dendritic	dendritic	ADJ
fnp-3806	4823	22	spine	spine	ADJ
fnp-3806	4823	23	loss	loss	NOUN
fnp-3806	4823	24	and	and	CCONJ
fnp-3806	4823	25	mitochondrial	mitochondrial	ADJ
fnp-3806	4823	26	abnormalities	abnormality	NOUN
fnp-3806	4823	27	in	in	ADP
fnp-3806	4823	28	a	a	DET
fnp-3806	4823	29	mouse	mouse	NOUN
fnp-3806	4823	30	model	model	NOUN
fnp-3806	4823	31	of	of	ADP
fnp-3806	4823	32	alzheimer	alzheimer	PROPN
fnp-3806	4823	33	's	's	PART
fnp-3806	4823	34	disease	disease	NOUN
fnp-3806	4823	35	.	.	PUNCT
fnp-3806	4824	1	hum	hum	PROPN
fnp-3806	4824	2	mol	mol	ADP
fnp-3806	4824	3	genet	genet	PROPN
fnp-3806	4824	4	2018;27:30	2018;27:30	NUM
fnp-3806	4824	5	-	-	SYM
fnp-3806	4824	6	40	40	NUM
fnp-3806	4824	7	.	.	PUNCT
fnp-3806	4825	1	https://doi.org/10.1093/hmg/ddx381	https://doi.org/10.1093/hmg/ddx381	PROPN
fnp-3806	4825	2	eckert	eckert	PROPN
fnp-3806	4825	3	a	a	PROPN
fnp-3806	4825	4	,	,	PUNCT
fnp-3806	4825	5	schulz	schulz	PROPN
fnp-3806	4825	6	kl	kl	PROPN
fnp-3806	4825	7	,	,	PUNCT
fnp-3806	4825	8	rhein	rhein	NOUN
fnp-3806	4825	9	v	v	NOUN
fnp-3806	4825	10	,	,	PUNCT
fnp-3806	4825	11	et	et	PROPN
fnp-3806	4825	12	al	al	PROPN
fnp-3806	4825	13	.	.	PROPN
fnp-3806	4825	14	convergence	convergence	NOUN
fnp-3806	4825	15	of	of	ADP
fnp-3806	4825	16	amyloid	amyloid	NOUN
fnp-3806	4825	17	-	-	PUNCT
fnp-3806	4825	18	beta	beta	NOUN
fnp-3806	4825	19	and	and	CCONJ
fnp-3806	4825	20	tau	tau	PROPN
fnp-3806	4825	21	on	on	ADP
fnp-3806	4825	22	mitochondria	mitochondria	NOUN
fnp-3806	4825	23	in	in	ADP
fnp-3806	4825	24	vivo	vivo	NOUN
fnp-3806	4825	25	.	.	PUNCT
fnp-3806	4826	1	mol	mol	ADP
fnp-3806	4826	2	neurobiol	neurobiol	PROPN
fnp-3806	4826	3	2010;41:107	2010;41:107	PROPN
fnp-3806	4826	4	-	-	SYM
fnp-3806	4826	5	114	114	NUM
fnp-3806	4826	6	.	.	PUNCT
fnp-3806	4827	1	https://doi.org/10.1007/s12035-010-8109-5	https://doi.org/10.1007/s12035-010-8109-5	PROPN
fnp-3806	4827	2	wilkins	wilkins	PROPN
fnp-3806	4827	3	hm	hm	INTJ
fnp-3806	4827	4	,	,	PUNCT
fnp-3806	4827	5	swerdlow	swerdlow	PROPN
fnp-3806	4827	6	rh	rh	PROPN
fnp-3806	4827	7	.	.	PUNCT
fnp-3806	4828	1	mitochondrial	mitochondrial	ADJ
fnp-3806	4828	2	links	link	NOUN
fnp-3806	4828	3	between	between	ADP
fnp-3806	4828	4	brain	brain	NOUN
fnp-3806	4828	5	aging	aging	NOUN
fnp-3806	4828	6	and	and	CCONJ
fnp-3806	4828	7	alzheimer	alzheimer	NOUN
fnp-3806	4828	8	's	's	PART
fnp-3806	4828	9	disease	disease	NOUN
fnp-3806	4828	10	.	.	PUNCT
fnp-3806	4829	1	transl	transl	PROPN
fnp-3806	4829	2	neurodegener	neurodegener	NOUN
fnp-3806	4829	3	2021;10:33	2021;10:33	NUM
fnp-3806	4829	4	.	.	PUNCT
fnp-3806	4830	1	https://doi.org/10.1186/s40035-021-00261-2	https://doi.org/10.1186/s40035-021-00261-2	NUM
fnp-3806	4830	2	hayashi	hayashi	PROPN
fnp-3806	4830	3	t	t	PROPN
fnp-3806	4830	4	,	,	PUNCT
fnp-3806	4830	5	rizzuto	rizzuto	PROPN
fnp-3806	4830	6	r	r	PROPN
fnp-3806	4830	7	,	,	PUNCT
fnp-3806	4830	8	hajnoczky	hajnoczky	ADJ
fnp-3806	4830	9	g	g	PROPN
fnp-3806	4830	10	,	,	PUNCT
fnp-3806	4830	11	su	su	PROPN
fnp-3806	4830	12	tp	tp	PROPN
fnp-3806	4830	13	.	.	PUNCT
fnp-3806	4831	1	mam	mam	PROPN
fnp-3806	4831	2	:	:	PUNCT
fnp-3806	4831	3	more	more	ADJ
fnp-3806	4831	4	than	than	ADP
fnp-3806	4831	5	just	just	ADV
fnp-3806	4831	6	a	a	DET
fnp-3806	4831	7	housekeeper	housekeeper	NOUN
fnp-3806	4831	8	.	.	PUNCT
fnp-3806	4832	1	trends	trend	NOUN
fnp-3806	4832	2	cell	cell	VERB
fnp-3806	4832	3	biol	biol	NOUN
fnp-3806	4832	4	2000;19:81	2000;19:81	NUM
fnp-3806	4832	5	-	-	SYM
fnp-3806	4832	6	88	88	NUM
fnp-3806	4832	7	.	.	PUNCT
fnp-3806	4833	1	https://doi.org/10.1186/s40035-021-00261-2	https://doi.org/10.1186/s40035-021-00261-2	AUX
fnp-3806	4833	2	eysert	eysert	PROPN
fnp-3806	4833	3	f	f	PROPN
fnp-3806	4833	4	,	,	PUNCT
fnp-3806	4833	5	kinoshita	kinoshita	PROPN
fnp-3806	4833	6	pf	pf	PROPN
fnp-3806	4833	7	,	,	PUNCT
fnp-3806	4833	8	mary	mary	PROPN
fnp-3806	4833	9	a	a	PROPN
fnp-3806	4833	10	,	,	PUNCT
fnp-3806	4833	11	et	et	PROPN
fnp-3806	4833	12	al	al	PROPN
fnp-3806	4833	13	.	.	PUNCT
fnp-3806	4834	1	molecular	molecular	ADJ
fnp-3806	4834	2	dysfunctions	dysfunction	NOUN
fnp-3806	4834	3	of	of	ADP
fnp-3806	4834	4	mitochondria	mitochondria	NOUN
fnp-3806	4834	5	-	-	PUNCT
fnp-3806	4834	6	associated	associate	VERB
fnp-3806	4834	7	membranes	membrane	NOUN
fnp-3806	4834	8	(	(	PUNCT
fnp-3806	4834	9	mams	mam	NOUN
fnp-3806	4834	10	)	)	PUNCT
fnp-3806	4834	11	in	in	ADP
fnp-3806	4834	12	alzheimer	alzheimer	PROPN
fnp-3806	4834	13	's	's	PART
fnp-3806	4834	14	disease	disease	NOUN
fnp-3806	4834	15	.	.	PUNCT
fnp-3806	4835	1	int	int	PROPN
fnp-3806	4835	2	j	j	PROPN
fnp-3806	4835	3	mol	mol	ADP
fnp-3806	4835	4	sci	sci	PROPN
fnp-3806	4835	5	2020;21:9521	2020;21:9521	NUM
fnp-3806	4835	6	.	.	PUNCT
fnp-3806	4836	1	https://doi.org/10.3390/ijms21249521	https://doi.org/10.3390/ijms21249521	NOUN
fnp-3806	4836	2	schon	schon	PROPN
fnp-3806	4836	3	ea	ea	PROPN
fnp-3806	4836	4	,	,	PUNCT
fnp-3806	4836	5	area	area	NOUN
fnp-3806	4836	6	-	-	PUNCT
fnp-3806	4836	7	gomez	gomez	PROPN
fnp-3806	4836	8	e.	e.	PROPN
fnp-3806	4836	9	mitochondria	mitochondria	PROPN
fnp-3806	4836	10	-	-	PUNCT
fnp-3806	4836	11	associated	associate	VERB
fnp-3806	4836	12	er	er	INTJ
fnp-3806	4836	13	membranes	membrane	NOUN
fnp-3806	4836	14	in	in	ADP
fnp-3806	4836	15	alzheimer	alzheimer	PROPN
fnp-3806	4836	16	disease	disease	PROPN
fnp-3806	4836	17	.	.	PUNCT
fnp-3806	4837	1	mol	mol	ADP
fnp-3806	4837	2	cell	cell	NOUN
fnp-3806	4837	3	neurosci	neurosci	NOUN
fnp-3806	4837	4	2013;55:26	2013;55:26	NUM
fnp-3806	4837	5	-	-	SYM
fnp-3806	4837	6	36	36	NUM
fnp-3806	4837	7	.	.	PUNCT
fnp-3806	4838	1	https://doi.org/10.1016/j.mcn.2012.07.011	https://doi.org/10.1016/j.mcn.2012.07.011	PROPN
fnp-3806	4838	2	area	area	NOUN
fnp-3806	4838	3	-	-	PUNCT
fnp-3806	4838	4	gomez	gomez	NOUN
fnp-3806	4838	5	e	e	PROPN
fnp-3806	4838	6	,	,	PUNCT
fnp-3806	4838	7	schon	schon	PROPN
fnp-3806	4838	8	e	e	PROPN
fnp-3806	4838	9	a.	a.	NOUN
fnp-3806	4838	10	mitochondria	mitochondria	PROPN
fnp-3806	4838	11	-	-	PUNCT
fnp-3806	4838	12	associated	associate	VERB
fnp-3806	4838	13	er	er	INTJ
fnp-3806	4838	14	membranes	membrane	NOUN
fnp-3806	4838	15	and	and	CCONJ
fnp-3806	4838	16	alzheimer	alzheimer	NOUN
fnp-3806	4838	17	disease	disease	NOUN
fnp-3806	4838	18	.	.	PUNCT
fnp-3806	4839	1	curr	curr	PROPN
fnp-3806	4839	2	opin	opin	PROPN
fnp-3806	4839	3	genet	genet	PROPN
fnp-3806	4839	4	dev	dev	PROPN
fnp-3806	4839	5	2016;38:90	2016;38:90	NUM
fnp-3806	4839	6	-	-	SYM
fnp-3806	4839	7	96	96	NUM
fnp-3806	4839	8	.	.	PUNCT
fnp-3806	4840	1	https://doi.org/10.1016/j.gde.2016.04.006	https://doi.org/10.1016/j.gde.2016.04.006	ADJ
fnp-3806	4840	2	area	area	NOUN
fnp-3806	4840	3	-	-	PUNCT
fnp-3806	4840	4	gomez	gomez	NOUN
fnp-3806	4840	5	e	e	PROPN
fnp-3806	4840	6	,	,	PUNCT
fnp-3806	4840	7	schon	schon	NOUN
fnp-3806	4840	8	ea	ea	PROPN
fnp-3806	4840	9	.	.	PUNCT
fnp-3806	4841	1	on	on	ADP
fnp-3806	4841	2	the	the	DET
fnp-3806	4841	3	pathogenesis	pathogenesis	NOUN
fnp-3806	4841	4	of	of	ADP
fnp-3806	4841	5	alzheimer	alzheimer	PROPN
fnp-3806	4841	6	’s	’s	PART
fnp-3806	4841	7	disease	disease	NOUN
fnp-3806	4841	8	:	:	PUNCT
fnp-3806	4841	9	the	the	DET
fnp-3806	4841	10	mam	mam	PROPN
fnp-3806	4841	11	hypothesis	hypothesis	NOUN
fnp-3806	4841	12	.	.	PUNCT
fnp-3806	4842	1	faseb	faseb	PROPN
fnp-3806	4842	2	j	j	PROPN
fnp-3806	4842	3	2017;31:864	2017;31:864	NUM
fnp-3806	4842	4	-	-	PUNCT
fnp-3806	4842	5	867	867	NUM
fnp-3806	4842	6	.	.	PUNCT
fnp-3806	4843	1	https://doi.org/10.1096/fj.201601309	https://doi.org/10.1096/fj.201601309	NOUN
fnp-3806	4843	2	pamplona	pamplona	PROPN
fnp-3806	4843	3	r.	r.	PROPN
fnp-3806	4843	4	membrane	membrane	PROPN
fnp-3806	4843	5	phospholipids	phospholipid	NOUN
fnp-3806	4843	6	,	,	PUNCT
fnp-3806	4843	7	lipoxidative	lipoxidative	ADJ
fnp-3806	4843	8	damage	damage	NOUN
fnp-3806	4843	9	and	and	CCONJ
fnp-3806	4843	10	molecular	molecular	ADJ
fnp-3806	4843	11	integrity	integrity	NOUN
fnp-3806	4843	12	:	:	PUNCT
fnp-3806	4843	13	a	a	DET
fnp-3806	4843	14	causal	causal	ADJ
fnp-3806	4843	15	role	role	NOUN
fnp-3806	4843	16	in	in	ADP
fnp-3806	4843	17	aging	aging	NOUN
fnp-3806	4843	18	and	and	CCONJ
fnp-3806	4843	19	longevity	longevity	NOUN
fnp-3806	4843	20	.	.	PUNCT
fnp-3806	4844	1	biochim	biochim	PROPN
fnp-3806	4844	2	biophys	biophy	NOUN
fnp-3806	4844	3	acta	acta	PROPN
fnp-3806	4844	4	2008	2008	NUM
fnp-3806	4844	5	;	;	PUNCT
fnp-3806	4844	6	1777:1249	1777:1249	NUM
fnp-3806	4844	7	-	-	SYM
fnp-3806	4844	8	1262	1262	NUM
fnp-3806	4844	9	.	.	PUNCT
fnp-3806	4845	1	https://doi.org/10.1016/j.bbabio.2008.07.003	https://doi.org/10.1016/j.bbabio.2008.07.003	NUM
fnp-3806	4845	2	zhao	zhao	PROPN
fnp-3806	4845	3	y	y	PROPN
fnp-3806	4845	4	,	,	PUNCT
fnp-3806	4845	5	zhao	zhao	PROPN
fnp-3806	4845	6	b.	b.	PROPN
fnp-3806	4845	7	oxidative	oxidative	ADJ
fnp-3806	4845	8	stress	stress	NOUN
fnp-3806	4845	9	and	and	CCONJ
fnp-3806	4845	10	the	the	DET
fnp-3806	4845	11	pathogenesis	pathogenesis	NOUN
fnp-3806	4845	12	of	of	ADP
fnp-3806	4845	13	alzheimer	alzheimer	PROPN
fnp-3806	4845	14	’s	’s	PART
fnp-3806	4845	15	disease	disease	NOUN
fnp-3806	4845	16	.	.	PUNCT
fnp-3806	4846	1	oxid	oxid	PROPN
fnp-3806	4846	2	med	med	PROPN
fnp-3806	4846	3	cell	cell	NOUN
fnp-3806	4846	4	longev	longev	NOUN
fnp-3806	4846	5	2013	2013	NUM
fnp-3806	4846	6	;	;	PUNCT
fnp-3806	4846	7	2013:316523	2013:316523	NUM
fnp-3806	4846	8	.	.	PUNCT
fnp-3806	4847	1	https://doi.org/10.1155/2013/316523	https://doi.org/10.1155/2013/316523	PROPN
fnp-3806	4847	2	thomas	thomas	PROPN
fnp-3806	4847	3	dd	dd	PROPN
fnp-3806	4847	4	,	,	PUNCT
fnp-3806	4847	5	ridnour	ridnour	ADJ
fnp-3806	4847	6	l	l	NOUN
fnp-3806	4847	7	,	,	PUNCT
fnp-3806	4847	8	donzelli	donzelli	PROPN
fnp-3806	4847	9	s	s	PROPN
fnp-3806	4847	10	,	,	PUNCT
fnp-3806	4847	11	et	et	PROPN
fnp-3806	4847	12	al	al	PROPN
fnp-3806	4847	13	.	.	PUNCT
fnp-3806	4848	1	the	the	DET
fnp-3806	4848	2	chemistry	chemistry	NOUN
fnp-3806	4848	3	of	of	ADP
fnp-3806	4848	4	protein	protein	NOUN
fnp-3806	4848	5	modifications	modification	NOUN
fnp-3806	4848	6	elicited	elicit	VERB
fnp-3806	4848	7	by	by	ADP
fnp-3806	4848	8	nitric	nitric	ADJ
fnp-3806	4848	9	oxide	oxide	NOUN
fnp-3806	4848	10	and	and	CCONJ
fnp-3806	4848	11	related	relate	VERB
fnp-3806	4848	12	nitrogen	nitrogen	NOUN
fnp-3806	4848	13	oxides	oxide	NOUN
fnp-3806	4848	14	.	.	PUNCT
fnp-3806	4849	1	in	in	ADP
fnp-3806	4849	2	:	:	PUNCT
fnp-3806	4849	3	redox	redox	ADJ
fnp-3806	4849	4	proteomics	proteomic	NOUN
fnp-3806	4849	5	:	:	PUNCT
fnp-3806	4849	6	from	from	ADP
fnp-3806	4849	7	protein	protein	NOUN
fnp-3806	4849	8	modifications	modification	NOUN
fnp-3806	4849	9	to	to	ADP
fnp-3806	4849	10	cellular	cellular	ADJ
fnp-3806	4849	11	dysfunction	dysfunction	NOUN
fnp-3806	4849	12	and	and	CCONJ
fnp-3806	4849	13	diseases	disease	NOUN
fnp-3806	4849	14	.	.	PUNCT
fnp-3806	4850	1	dalle	dalle	NOUN
fnp-3806	4850	2	-	-	PUNCT
fnp-3806	4850	3	done	do	VERB
fnp-3806	4850	4	i	i	PRON
fnp-3806	4850	5	,	,	PUNCT
fnp-3806	4850	6	scaloni	scaloni	PROPN
fnp-3806	4850	7	a	a	NOUN
fnp-3806	4850	8	,	,	PUNCT
fnp-3806	4850	9	butterfield	butterfield	PROPN
fnp-3806	4850	10	da	da	PROPN
fnp-3806	4850	11	(	(	PUNCT
fnp-3806	4850	12	eds	ed	NOUN
fnp-3806	4850	13	)	)	PUNCT
fnp-3806	4850	14	.	.	PUNCT
fnp-3806	4851	1	johnwiley	johnwiley	PROPN
fnp-3806	4851	2	&	&	CCONJ
fnp-3806	4851	3	sons	son	NOUN
fnp-3806	4851	4	,	,	PUNCT
fnp-3806	4851	5	2006	2006	NUM
fnp-3806	4851	6	:	:	PUNCT
fnp-3806	4851	7	25	25	NUM
fnp-3806	4851	8	-	-	SYM
fnp-3806	4851	9	58	58	NUM
fnp-3806	4851	10	.	.	PUNCT
fnp-3806	4852	1	cabré	cabré	PROPN
fnp-3806	4852	2	r	r	PROPN
fnp-3806	4852	3	,	,	PUNCT
fnp-3806	4852	4	naudí	naudí	VERB
fnp-3806	4852	5	a	a	DET
fnp-3806	4852	6	,	,	PUNCT
fnp-3806	4852	7	dominguez	dominguez	PROPN
fnp-3806	4852	8	-	-	PUNCT
fnp-3806	4852	9	gonzalez	gonzalez	PROPN
fnp-3806	4852	10	m	m	PROPN
fnp-3806	4852	11	,	,	PUNCT
fnp-3806	4852	12	et	et	PROPN
fnp-3806	4852	13	al	al	PROPN
fnp-3806	4852	14	.	.	PROPN
fnp-3806	4853	1	sixty	sixty	NUM
fnp-3806	4853	2	years	year	NOUN
fnp-3806	4853	3	old	old	ADJ
fnp-3806	4853	4	is	be	AUX
fnp-3806	4853	5	the	the	DET
fnp-3806	4853	6	breakpoint	breakpoint	NOUN
fnp-3806	4853	7	of	of	ADP
fnp-3806	4853	8	human	human	ADJ
fnp-3806	4853	9	frontal	frontal	ADJ
fnp-3806	4853	10	cortex	cortex	NOUN
fnp-3806	4853	11	aging	aging	NOUN
fnp-3806	4853	12	.	.	PUNCT
fnp-3806	4854	1	free	free	ADJ
fnp-3806	4854	2	radic	radic	ADJ
fnp-3806	4854	3	biol	biol	PROPN
fnp-3806	4854	4	med	me	VERB
fnp-3806	4854	5	2017;103:14	2017;103:14	NOUN
fnp-3806	4854	6	-	-	SYM
fnp-3806	4854	7	22	22	NUM
fnp-3806	4854	8	.	.	PUNCT
fnp-3806	4855	1	https://doi.org/10.1016/j.freeradbiomed.2016.12.010	https://doi.org/10.1016/j.freeradbiomed.2016.12.010	NUM
fnp-3806	4855	2	domínguez	domínguez	NOUN
fnp-3806	4855	3	m	m	PROPN
fnp-3806	4855	4	,	,	PUNCT
fnp-3806	4855	5	de	de	PROPN
fnp-3806	4855	6	oliveira	oliveira	PROPN
fnp-3806	4855	7	e	e	PROPN
fnp-3806	4855	8	,	,	PUNCT
fnp-3806	4855	9	odena	odena	PROPN
fnp-3806	4855	10	ma	ma	PROPN
fnp-3806	4855	11	,	,	PUNCT
fnp-3806	4855	12	et	et	PROPN
fnp-3806	4855	13	al	al	PROPN
fnp-3806	4855	14	.	.	PUNCT
fnp-3806	4856	1	redox	redox	ADJ
fnp-3806	4856	2	proteomic	proteomic	NOUN
fnp-3806	4856	3	profiling	profiling	NOUN
fnp-3806	4856	4	of	of	ADP
fnp-3806	4856	5	neuroketal	neuroketal	NOUN
fnp-3806	4856	6	-	-	PUNCT
fnp-3806	4856	7	adducted	adduct	VERB
fnp-3806	4856	8	proteins	protein	NOUN
fnp-3806	4856	9	in	in	ADP
fnp-3806	4856	10	human	human	ADJ
fnp-3806	4856	11	brain	brain	NOUN
fnp-3806	4856	12	:	:	PUNCT
fnp-3806	4856	13	regional	regional	ADJ
fnp-3806	4856	14	vulnerability	vulnerability	NOUN
fnp-3806	4856	15	at	at	ADP
fnp-3806	4856	16	middle	middle	ADJ
fnp-3806	4856	17	age	age	NOUN
fnp-3806	4856	18	increases	increase	NOUN
fnp-3806	4856	19	in	in	ADP
fnp-3806	4856	20	the	the	DET
fnp-3806	4856	21	elderly	elderly	ADJ
fnp-3806	4856	22	.	.	PUNCT
fnp-3806	4857	1	free	free	ADJ
fnp-3806	4857	2	radic	radic	ADJ
fnp-3806	4857	3	biol	biol	PROPN
fnp-3806	4857	4	med	me	VERB
fnp-3806	4857	5	2016;95:1	2016;95:1	NUM
fnp-3806	4857	6	-	-	SYM
fnp-3806	4857	7	15	15	NUM
fnp-3806	4857	8	.	.	PUNCT
fnp-3806	4858	1	https://doi.org/10.1016/j.freeradbiomed.2016.02.034	https://doi.org/10.1016/j.freeradbiomed.2016.02.034	ADJ
fnp-3806	4858	2	choi	choi	NOUN
fnp-3806	4858	3	wt	wt	NOUN
fnp-3806	4858	4	,	,	PUNCT
fnp-3806	4858	5	tosun	tosun	NOUN
fnp-3806	4858	6	m	m	PROPN
fnp-3806	4858	7	,	,	PUNCT
fnp-3806	4858	8	jeong	jeong	PROPN
fnp-3806	4858	9	hh	hh	PROPN
fnp-3806	4858	10	,	,	PUNCT
fnp-3806	4858	11	et	et	PROPN
fnp-3806	4858	12	al	al	PROPN
fnp-3806	4858	13	.	.	PUNCT
fnp-3806	4859	1	metabolomics	metabolomic	NOUN
fnp-3806	4859	2	of	of	ADP
fnp-3806	4859	3	mammalian	mammalian	ADJ
fnp-3806	4859	4	brain	brain	NOUN
fnp-3806	4859	5	reveals	reveal	VERB
fnp-3806	4859	6	regional	regional	ADJ
fnp-3806	4859	7	differences	difference	NOUN
fnp-3806	4859	8	.	.	PUNCT
fnp-3806	4860	1	bmc	bmc	PROPN
fnp-3806	4860	2	syst	syst	PROPN
fnp-3806	4860	3	biol	biol	PROPN
fnp-3806	4860	4	2018;12:127	2018;12:127	NUM
fnp-3806	4860	5	.	.	PUNCT
fnp-3806	4861	1	https://doi.org/10.1186/s12918-018-0644-0	https://doi.org/10.1186/s12918-018-0644-0	NUM
fnp-3806	4861	2	cabré	cabré	PROPN
fnp-3806	4861	3	r	r	NOUN
fnp-3806	4861	4	,	,	PUNCT
fnp-3806	4861	5	jové	jové	PROPN
fnp-3806	4861	6	m	m	PROPN
fnp-3806	4861	7	,	,	PUNCT
fnp-3806	4861	8	naudí	naudí	VERB
fnp-3806	4861	9	a	a	PRON
fnp-3806	4861	10	,	,	PUNCT
fnp-3806	4861	11	et	et	PROPN
fnp-3806	4861	12	al	al	PROPN
fnp-3806	4861	13	.	.	PROPN
fnp-3806	4862	1	specific	specific	VERB
fnp-3806	4862	2	metabolomics	metabolomic	NOUN
fnp-3806	4862	3	adaptations	adaptation	NOUN
fnp-3806	4862	4	define	define	VERB
fnp-3806	4862	5	a	a	DET
fnp-3806	4862	6	differential	differential	ADJ
fnp-3806	4862	7	regional	regional	ADJ
fnp-3806	4862	8	vulnerability	vulnerability	NOUN
fnp-3806	4862	9	in	in	ADP
fnp-3806	4862	10	the	the	DET
fnp-3806	4862	11	adult	adult	NOUN
fnp-3806	4862	12	human	human	ADJ
fnp-3806	4862	13	cerebral	cerebral	ADJ
fnp-3806	4862	14	cortex	cortex	NOUN
fnp-3806	4862	15	.	.	PUNCT
fnp-3806	4863	1	front	front	NOUN
fnp-3806	4863	2	mol	mol	ADP
fnp-3806	4863	3	neurosci	neurosci	PROPN
fnp-3806	4863	4	2016;9:138	2016;9:138	PROPN
fnp-3806	4863	5	.	.	PUNCT
fnp-3806	4864	1	https://doi.org/10.3389/fnmol.2016.00138	https://doi.org/10.3389/fnmol.2016.00138	PROPN
fnp-3806	4864	2	domínguez	domínguez	PROPN
fnp-3806	4864	3	-	-	PUNCT
fnp-3806	4864	4	gonzález	gonzález	PROPN
fnp-3806	4864	5	m	m	PROPN
fnp-3806	4864	6	,	,	PUNCT
fnp-3806	4864	7	puigpinós	puigpinós	PROPN
fnp-3806	4864	8	m	m	PROPN
fnp-3806	4864	9	,	,	PUNCT
fnp-3806	4864	10	jové	jové	PROPN
fnp-3806	4864	11	m	m	PROPN
fnp-3806	4864	12	,	,	PUNCT
fnp-3806	4864	13	et	et	PROPN
fnp-3806	4864	14	al	al	PROPN
fnp-3806	4864	15	.	.	PUNCT
fnp-3806	4865	1	regional	regional	ADJ
fnp-3806	4865	2	vulnerability	vulnerability	NOUN
fnp-3806	4865	3	to	to	PART
fnp-3806	4865	4	lipoxidative	lipoxidative	ADJ
fnp-3806	4865	5	damage	damage	NOUN
fnp-3806	4865	6	and	and	CCONJ
fnp-3806	4865	7	inflammation	inflammation	NOUN
fnp-3806	4865	8	in	in	ADP
fnp-3806	4865	9	normal	normal	ADJ
fnp-3806	4865	10	human	human	ADJ
fnp-3806	4865	11	brain	brain	NOUN
fnp-3806	4865	12	aging	aging	NOUN
fnp-3806	4865	13	.	.	PUNCT
fnp-3806	4866	1	exp	exp	NOUN
fnp-3806	4866	2	gerontol	gerontol	ADJ
fnp-3806	4866	3	2018;111:218	2018;111:218	NUM
fnp-3806	4866	4	-	-	SYM
fnp-3806	4866	5	228	228	NUM
fnp-3806	4866	6	.	.	PUNCT
fnp-3806	4867	1	https://doi.org/10.1016/j.exger.2018.07.023	https://doi.org/10.1016/j.exger.2018.07.023	PROPN
fnp-3806	4867	2	srikanth	srikanth	PROPN
fnp-3806	4867	3	v	v	NOUN
fnp-3806	4867	4	,	,	PUNCT
fnp-3806	4867	5	maczurek	maczurek	AUX
fnp-3806	4867	6	a	a	PRON
fnp-3806	4867	7	,	,	PUNCT
fnp-3806	4867	8	phan	phan	PROPN
fnp-3806	4867	9	t	t	PROPN
fnp-3806	4867	10	,	,	PUNCT
fnp-3806	4867	11	et	et	PROPN
fnp-3806	4867	12	al	al	PROPN
fnp-3806	4867	13	.	.	PROPN
fnp-3806	4868	1	advanced	advanced	ADJ
fnp-3806	4868	2	glycation	glycation	NOUN
fnp-3806	4868	3	endproducts	endproduct	NOUN
fnp-3806	4868	4	and	and	CCONJ
fnp-3806	4868	5	their	their	PRON
fnp-3806	4868	6	receptor	receptor	NOUN
fnp-3806	4868	7	rage	rage	NOUN
fnp-3806	4868	8	in	in	ADP
fnp-3806	4868	9	alzheimer	alzheimer	PROPN
fnp-3806	4868	10	's	's	PART
fnp-3806	4868	11	disease	disease	NOUN
fnp-3806	4868	12	.	.	PUNCT
fnp-3806	4869	1	neurobiol	neurobiol	PROPN
fnp-3806	4869	2	aging	age	VERB
fnp-3806	4869	3	2011;32:763	2011;32:763	PROPN
fnp-3806	4869	4	-	-	SYM
fnp-3806	4869	5	777	777	NUM
fnp-3806	4869	6	.	.	PUNCT
fnp-3806	4870	1	https://doi.org/10.1016/j.neurobiolaging.2009.04.016	https://doi.org/10.1016/j.neurobiolaging.2009.04.016	PROPN
fnp-3806	4870	2	chambers	chamber	NOUN
fnp-3806	4870	3	a	a	PRON
fnp-3806	4870	4	,	,	PUNCT
fnp-3806	4870	5	bury	bury	PROPN
fnp-3806	4870	6	jj	jj	PROPN
fnp-3806	4870	7	,	,	PUNCT
fnp-3806	4870	8	minett	minett	PROPN
fnp-3806	4870	9	t	t	PROPN
fnp-3806	4870	10	,	,	PUNCT
fnp-3806	4870	11	et	et	PROPN
fnp-3806	4870	12	al	al	PROPN
fnp-3806	4870	13	.	.	PROPN
fnp-3806	4871	1	advanced	advanced	ADJ
fnp-3806	4871	2	glycation	glycation	NOUN
fnp-3806	4871	3	end	end	NOUN
fnp-3806	4871	4	product	product	NOUN
fnp-3806	4871	5	formation	formation	NOUN
fnp-3806	4871	6	in	in	ADP
fnp-3806	4871	7	human	human	ADJ
fnp-3806	4871	8	cerebral	cerebral	ADJ
fnp-3806	4871	9	cortex	cortex	NOUN
fnp-3806	4871	10	increases	increase	NOUN
fnp-3806	4871	11	with	with	ADP
fnp-3806	4871	12	alzheimer	alzheimer	ADJ
fnp-3806	4871	13	-	-	PUNCT
fnp-3806	4871	14	type	type	NOUN
fnp-3806	4871	15	neuropathologic	neuropathologic	ADJ
fnp-3806	4871	16	changes	change	NOUN
fnp-3806	4871	17	but	but	CCONJ
fnp-3806	4871	18	is	be	AUX
fnp-3806	4871	19	not	not	PART
fnp-3806	4871	20	independently	independently	ADV
fnp-3806	4871	21	associated	associate	VERB
fnp-3806	4871	22	with	with	ADP
fnp-3806	4871	23	dementia	dementia	NOUN
fnp-3806	4871	24	in	in	ADP
fnp-3806	4871	25	a	a	DET
fnp-3806	4871	26	population	population	NOUN
fnp-3806	4871	27	-	-	PUNCT
fnp-3806	4871	28	derived	derive	VERB
fnp-3806	4871	29	aging	age	VERB
fnp-3806	4871	30	brain	brain	NOUN
fnp-3806	4871	31	cohort	cohort	NOUN
fnp-3806	4871	32	.	.	PUNCT
fnp-3806	4872	1	j	j	PROPN
fnp-3806	4872	2	neuropathol	neuropathol	PROPN
fnp-3806	4872	3	exp	exp	PROPN
fnp-3806	4872	4	neurol	neurol	PROPN
fnp-3806	4872	5	2020;79:950	2020;79:950	PROPN
fnp-3806	4872	6	-	-	SYM
fnp-3806	4872	7	958	958	NUM
fnp-3806	4872	8	.	.	PUNCT
fnp-3806	4873	1	https://doi.org/10.1093/jnen/nlaa064	https://doi.org/10.1093/jnen/nlaa064	PROPN
fnp-3806	4873	2	korolainen	korolainen	PROPN
fnp-3806	4873	3	ma	ma	PROPN
fnp-3806	4873	4	,	,	PUNCT
fnp-3806	4873	5	auriola	auriola	PROPN
fnp-3806	4873	6	s	s	PROPN
fnp-3806	4873	7	,	,	PUNCT
fnp-3806	4873	8	nyman	nyman	PROPN
fnp-3806	4873	9	ta	ta	PROPN
fnp-3806	4873	10	,	,	PUNCT
fnp-3806	4873	11	et	et	PROPN
fnp-3806	4873	12	al	al	PROPN
fnp-3806	4873	13	.	.	PROPN
fnp-3806	4874	1	proteomic	proteomic	ADJ
fnp-3806	4874	2	analysis	analysis	NOUN
fnp-3806	4874	3	of	of	ADP
fnp-3806	4874	4	glial	glial	ADJ
fnp-3806	4874	5	fibrillary	fibrillary	ADJ
fnp-3806	4874	6	acidic	acidic	ADJ
fnp-3806	4874	7	protein	protein	NOUN
fnp-3806	4874	8	in	in	ADP
fnp-3806	4874	9	alzheimer	alzheimer	PROPN
fnp-3806	4874	10	’s	’s	PART
fnp-3806	4874	11	disease	disease	NOUN
fnp-3806	4874	12	and	and	CCONJ
fnp-3806	4874	13	aging	age	VERB
fnp-3806	4874	14	brain	brain	NOUN
fnp-3806	4874	15	.	.	PUNCT
fnp-3806	4875	1	neurobiol	neurobiol	PROPN
fnp-3806	4875	2	dis	dis	PROPN
fnp-3806	4875	3	2005;20:858	2005;20:858	NUM
fnp-3806	4875	4	-	-	SYM
fnp-3806	4875	5	870	870	NUM
fnp-3806	4875	6	.	.	PUNCT
fnp-3806	4876	1	https://doi.org/10.1016/j.nbd.2005.05.021	https://doi.org/10.1016/j.nbd.2005.05.021	PROPN
fnp-3806	4876	2	korolainen	korolainen	PROPN
fnp-3806	4876	3	ma	ma	PROPN
fnp-3806	4876	4	,	,	PUNCT
fnp-3806	4876	5	goldsteins	goldstein	VERB
fnp-3806	4876	6	g	g	PROPN
fnp-3806	4876	7	,	,	PUNCT
fnp-3806	4876	8	nyman	nyman	PROPN
fnp-3806	4877	1	ta	ta	PROPN
fnp-3806	4877	2	,	,	PUNCT
fnp-3806	4877	3	et	et	PROPN
fnp-3806	4877	4	al	al	PROPN
fnp-3806	4877	5	.	.	PROPN
fnp-3806	4877	6	oxidative	oxidative	ADJ
fnp-3806	4877	7	modification	modification	NOUN
fnp-3806	4877	8	of	of	ADP
fnp-3806	4877	9	proteins	protein	NOUN
fnp-3806	4877	10	in	in	ADP
fnp-3806	4877	11	the	the	DET
fnp-3806	4877	12	frontal	frontal	ADJ
fnp-3806	4877	13	cortex	cortex	NOUN
fnp-3806	4877	14	of	of	ADP
fnp-3806	4877	15	alzheimer	alzheimer	PROPN
fnp-3806	4877	16	’s	’s	PART
fnp-3806	4877	17	disease	disease	NOUN
fnp-3806	4877	18	brain	brain	NOUN
fnp-3806	4877	19	.	.	PUNCT
fnp-3806	4878	1	neurobiol	neurobiol	PROPN
fnp-3806	4878	2	aging	age	VERB
fnp-3806	4878	3	2006;27:42	2006;27:42	NUM
fnp-3806	4878	4	-	-	SYM
fnp-3806	4878	5	53	53	NUM
fnp-3806	4878	6	.	.	PUNCT
fnp-3806	4879	1	https://doi.org/10.1016/j.neurobiolaging.2004.11.010	https://doi.org/10.1016/j.neurobiolaging.2004.11.010	PROPN
fnp-3806	4879	2	butterfield	butterfield	PROPN
fnp-3806	4879	3	da	da	PROPN
fnp-3806	4879	4	,	,	PUNCT
fnp-3806	4879	5	sultana	sultana	PROPN
fnp-3806	4879	6	r.	r.	PROPN
fnp-3806	4879	7	redox	redox	PROPN
fnp-3806	4879	8	proteomics	proteomic	NOUN
fnp-3806	4879	9	:	:	PUNCT
fnp-3806	4879	10	understanding	understanding	NOUN
fnp-3806	4879	11	oxidative	oxidative	ADJ
fnp-3806	4879	12	stress	stress	NOUN
fnp-3806	4879	13	in	in	ADP
fnp-3806	4879	14	the	the	DET
fnp-3806	4879	15	progression	progression	NOUN
fnp-3806	4879	16	of	of	ADP
fnp-3806	4879	17	age	age	NOUN
fnp-3806	4879	18	-	-	PUNCT
fnp-3806	4879	19	related	relate	VERB
fnp-3806	4879	20	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4879	21	disorders	disorder	NOUN
fnp-3806	4879	22	.	.	PUNCT
fnp-3806	4880	1	expert	expert	NOUN
fnp-3806	4880	2	rev	rev	PROPN
fnp-3806	4880	3	proteomics	proteomic	NOUN
fnp-3806	4880	4	2008	2008	NUM
fnp-3806	4880	5	;	;	PUNCT
fnp-3806	4880	6	5:157	5:157	NUM
fnp-3806	4880	7	-	-	SYM
fnp-3806	4880	8	160	160	NUM
fnp-3806	4880	9	.	.	PUNCT
fnp-3806	4881	1	https://doi.org/10.1586/14789450.5.2.157	https://doi.org/10.1586/14789450.5.2.157	PROPN
fnp-3806	4881	2	butterfield	butterfield	PROPN
fnp-3806	4881	3	da	da	PROPN
fnp-3806	4881	4	,	,	PUNCT
fnp-3806	4881	5	abdul	abdul	PROPN
fnp-3806	4881	6	hm	hm	PROPN
fnp-3806	4881	7	,	,	PUNCT
fnp-3806	4881	8	newman	newman	PROPN
fnp-3806	4881	9	s	s	PROPN
fnp-3806	4881	10	,	,	PUNCT
fnp-3806	4881	11	et	et	PROPN
fnp-3806	4881	12	al	al	PROPN
fnp-3806	4881	13	.	.	PUNCT
fnp-3806	4882	1	redox	redox	ADJ
fnp-3806	4882	2	proteomics	proteomic	NOUN
fnp-3806	4882	3	in	in	ADP
fnp-3806	4882	4	some	some	DET
fnp-3806	4882	5	age	age	NOUN
fnp-3806	4882	6	-	-	PUNCT
fnp-3806	4882	7	related	relate	VERB
fnp-3806	4882	8	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4882	9	disorders	disorder	NOUN
fnp-3806	4882	10	or	or	CCONJ
fnp-3806	4882	11	models	model	NOUN
fnp-3806	4882	12	thereof	thereof	ADV
fnp-3806	4882	13	.	.	PUNCT
fnp-3806	4883	1	neurorx	neurorx	PROPN
fnp-3806	4883	2	2006	2006	NUM
fnp-3806	4883	3	;	;	PUNCT
fnp-3806	4883	4	3:344	3:344	NUM
fnp-3806	4883	5	-	-	SYM
fnp-3806	4883	6	357	357	NUM
fnp-3806	4883	7	.	.	PUNCT
fnp-3806	4884	1	https://doi.org/10.1016/j.nurx.2006.05.003	https://doi.org/10.1016/j.nurx.2006.05.003	PROPN
fnp-3806	4884	2	butterfield	butterfield	PROPN
fnp-3806	4884	3	da	da	PROPN
fnp-3806	4884	4	,	,	PUNCT
fnp-3806	4884	5	gnjec	gnjec	NOUN
fnp-3806	4884	6	a	a	PRON
fnp-3806	4884	7	,	,	PUNCT
fnp-3806	4884	8	poon	poon	NOUN
fnp-3806	4884	9	hf	hf	NOUN
fnp-3806	4884	10	,	,	PUNCT
fnp-3806	4884	11	et	et	PROPN
fnp-3806	4884	12	al	al	PROPN
fnp-3806	4884	13	.	.	PUNCT
fnp-3806	4884	14	redox	redox	ADJ
fnp-3806	4884	15	proteomics	proteomic	NOUN
fnp-3806	4884	16	identification	identification	NOUN
fnp-3806	4884	17	of	of	ADP
fnp-3806	4884	18	oxidatively	oxidatively	ADV
fnp-3806	4884	19	modified	modify	VERB
fnp-3806	4884	20	brain	brain	NOUN
fnp-3806	4884	21	proteins	protein	NOUN
fnp-3806	4884	22	in	in	ADP
fnp-3806	4884	23	inherited	inherit	VERB
fnp-3806	4884	24	alzheimer	alzheimer	PROPN
fnp-3806	4884	25	’s	’s	PART
fnp-3806	4884	26	disease	disease	NOUN
fnp-3806	4884	27	:	:	PUNCT
fnp-3806	4884	28	an	an	DET
fnp-3806	4884	29	initial	initial	ADJ
fnp-3806	4884	30	assessment	assessment	NOUN
fnp-3806	4884	31	.	.	PUNCT
fnp-3806	4885	1	j	j	PROPN
fnp-3806	4885	2	alzheimers	alzheimers	PROPN
fnp-3806	4885	3	dis	dis	PROPN
fnp-3806	4885	4	2006;10:391	2006;10:391	NUM
fnp-3806	4885	5	-	-	SYM
fnp-3806	4885	6	397	397	NUM
fnp-3806	4885	7	.	.	PUNCT
fnp-3806	4886	1	https://doi.org/10.3233/jad-2006-10407	https://doi.org/10.3233/jad-2006-10407	PROPN
fnp-3806	4886	2	butterfield	butterfield	PROPN
fnp-3806	4886	3	da	da	PROPN
fnp-3806	4886	4	,	,	PUNCT
fnp-3806	4886	5	poon	poon	NOUN
fnp-3806	4886	6	hf	hf	NOUN
fnp-3806	4886	7	,	,	PUNCT
fnp-3806	4886	8	st	st	PROPN
fnp-3806	4886	9	clair	clair	PROPN
fnp-3806	4886	10	d	d	PROPN
fnp-3806	4886	11	,	,	PUNCT
fnp-3806	4886	12	et	et	PROPN
fnp-3806	4886	13	al	al	PROPN
fnp-3806	4886	14	.	.	PUNCT
fnp-3806	4887	1	redox	redox	ADJ
fnp-3806	4887	2	proteomics	proteomic	NOUN
fnp-3806	4887	3	identification	identification	NOUN
fnp-3806	4887	4	of	of	ADP
fnp-3806	4887	5	oxidatively	oxidatively	ADV
fnp-3806	4887	6	modified	modify	VERB
fnp-3806	4887	7	hippocampal	hippocampal	ADJ
fnp-3806	4887	8	proteins	protein	NOUN
fnp-3806	4887	9	in	in	ADP
fnp-3806	4887	10	mild	mild	ADJ
fnp-3806	4887	11	cognitive	cognitive	ADJ
fnp-3806	4887	12	impairment	impairment	NOUN
fnp-3806	4887	13	:	:	PUNCT
fnp-3806	4887	14	insights	insight	NOUN
fnp-3806	4887	15	into	into	ADP
fnp-3806	4887	16	the	the	DET
fnp-3806	4887	17	development	development	NOUN
fnp-3806	4887	18	of	of	ADP
fnp-3806	4887	19	alzheimer	alzheimer	PROPN
fnp-3806	4887	20	’s	’s	PART
fnp-3806	4887	21	disease	disease	NOUN
fnp-3806	4887	22	.	.	PUNCT
fnp-3806	4888	1	neurobiol	neurobiol	PROPN
fnp-3806	4888	2	dis	dis	PROPN
fnp-3806	4889	1	2006;22:223	2006;22:223	NUM
fnp-3806	4889	2	-	-	SYM
fnp-3806	4889	3	232	232	NUM
fnp-3806	4889	4	.	.	PUNCT
fnp-3806	4890	1	https://doi.org/10.1016/j.nbd.2005.11.002	https://doi.org/10.1016/j.nbd.2005.11.002	PROPN
fnp-3806	4890	2	sultana	sultana	PROPN
fnp-3806	4890	3	r	r	PROPN
fnp-3806	4890	4	,	,	PUNCT
fnp-3806	4890	5	boyd	boyd	PROPN
fnp-3806	4890	6	-	-	PUNCT
fnp-3806	4890	7	kimball	kimball	PROPN
fnp-3806	4890	8	d	d	PROPN
fnp-3806	4890	9	,	,	PUNCT
fnp-3806	4890	10	poon	poon	NOUN
fnp-3806	4890	11	hf	hf	NOUN
fnp-3806	4890	12	,	,	PUNCT
fnp-3806	4890	13	et	et	PROPN
fnp-3806	4890	14	al	al	PROPN
fnp-3806	4890	15	.	.	PUNCT
fnp-3806	4891	1	redox	redox	ADJ
fnp-3806	4891	2	proteomics	proteomic	NOUN
fnp-3806	4891	3	identification	identification	NOUN
fnp-3806	4891	4	of	of	ADP
fnp-3806	4891	5	oxidized	oxidized	ADJ
fnp-3806	4891	6	proteins	protein	NOUN
fnp-3806	4891	7	in	in	ADP
fnp-3806	4891	8	alzheimer	alzheimer	PROPN
fnp-3806	4891	9	’s	’s	PART
fnp-3806	4891	10	disease	disease	NOUN
fnp-3806	4891	11	hippocampus	hippocampus	NOUN
fnp-3806	4891	12	and	and	CCONJ
fnp-3806	4891	13	cerebellum	cerebellum	NOUN
fnp-3806	4891	14	:	:	PUNCT
fnp-3806	4891	15	an	an	DET
fnp-3806	4891	16	approach	approach	NOUN
fnp-3806	4891	17	to	to	PART
fnp-3806	4891	18	understand	understand	VERB
fnp-3806	4891	19	pathological	pathological	ADJ
fnp-3806	4891	20	and	and	CCONJ
fnp-3806	4891	21	biochemical	biochemical	ADJ
fnp-3806	4891	22	alterations	alteration	NOUN
fnp-3806	4891	23	in	in	ADP
fnp-3806	4891	24	ad	ad	NOUN
fnp-3806	4891	25	.	.	PUNCT
fnp-3806	4892	1	neurobiol	neurobiol	PROPN
fnp-3806	4892	2	aging	age	VERB
fnp-3806	4892	3	2006;27:1564	2006;27:1564	PROPN
fnp-3806	4892	4	-	-	SYM
fnp-3806	4892	5	1576	1576	NUM
fnp-3806	4892	6	.	.	PUNCT
fnp-3806	4893	1	https://doi.org/10.1016/j.neurobiolaging.2005.09.021	https://doi.org/10.1016/j.neurobiolaging.2005.09.021	NUM
fnp-3806	4893	2	sultana	sultana	NOUN
fnp-3806	4893	3	r	r	NOUN
fnp-3806	4893	4	,	,	PUNCT
fnp-3806	4893	5	poon	poon	NOUN
fnp-3806	4893	6	hf	hf	NOUN
fnp-3806	4893	7	,	,	PUNCT
fnp-3806	4893	8	cai	cai	PROPN
fnp-3806	4893	9	j	j	PROPN
fnp-3806	4893	10	,	,	PUNCT
fnp-3806	4893	11	et	et	PROPN
fnp-3806	4893	12	al	al	PROPN
fnp-3806	4893	13	.	.	PUNCT
fnp-3806	4893	14	identification	identification	NOUN
fnp-3806	4893	15	of	of	ADP
fnp-3806	4893	16	nitrated	nitrated	ADJ
fnp-3806	4893	17	proteins	protein	NOUN
fnp-3806	4893	18	in	in	ADP
fnp-3806	4893	19	alzheimer	alzheimer	PROPN
fnp-3806	4893	20	’s	’s	PART
fnp-3806	4893	21	disease	disease	NOUN
fnp-3806	4893	22	brain	brain	NOUN
fnp-3806	4893	23	using	use	VERB
fnp-3806	4893	24	a	a	DET
fnp-3806	4893	25	redox	redox	ADJ
fnp-3806	4893	26	proteomics	proteomic	NOUN
fnp-3806	4893	27	approach	approach	NOUN
fnp-3806	4893	28	.	.	PUNCT
fnp-3806	4894	1	neurobiol	neurobiol	PROPN
fnp-3806	4894	2	dis	dis	PROPN
fnp-3806	4894	3	2006;22:76	2006;22:76	NUM
fnp-3806	4894	4	-	-	SYM
fnp-3806	4894	5	87	87	NUM
fnp-3806	4894	6	.	.	PUNCT
fnp-3806	4895	1	https://doi.org/10.1016/j.nbd.2005.10.004	https://doi.org/10.1016/j.nbd.2005.10.004	NOUN
fnp-3806	4895	2	reed	reed	NOUN
fnp-3806	4895	3	t	t	PROPN
fnp-3806	4895	4	,	,	PUNCT
fnp-3806	4895	5	perluigi	perluigi	PROPN
fnp-3806	4895	6	m	m	PROPN
fnp-3806	4895	7	,	,	PUNCT
fnp-3806	4895	8	sultana	sultana	NOUN
fnp-3806	4895	9	r	r	PROPN
fnp-3806	4895	10	,	,	PUNCT
fnp-3806	4895	11	pierce	pierce	PROPN
fnp-3806	4895	12	wm	wm	PROPN
fnp-3806	4895	13	,	,	PUNCT
fnp-3806	4895	14	et	et	PROPN
fnp-3806	4895	15	al	al	PROPN
fnp-3806	4895	16	.	.	PROPN
fnp-3806	4896	1	proteomic	proteomic	ADJ
fnp-3806	4896	2	identification	identification	NOUN
fnp-3806	4896	3	of	of	ADP
fnp-3806	4896	4	4	4	NUM
fnp-3806	4896	5	-	-	PUNCT
fnp-3806	4896	6	hydroxy-2	hydroxy-2	NOUN
fnp-3806	4896	7	-	-	PUNCT
fnp-3806	4896	8	nonenal	nonenal	ADJ
fnp-3806	4896	9	modified	modify	VERB
fnp-3806	4896	10	brain	brain	NOUN
fnp-3806	4896	11	proteins	protein	NOUN
fnp-3806	4896	12	in	in	ADP
fnp-3806	4896	13	amnestic	amnestic	ADJ
fnp-3806	4896	14	mild	mild	ADJ
fnp-3806	4896	15	cognitive	cognitive	ADJ
fnp-3806	4896	16	impairment	impairment	NOUN
fnp-3806	4896	17	:	:	PUNCT
fnp-3806	4896	18	insight	insight	NOUN
fnp-3806	4896	19	into	into	ADP
fnp-3806	4896	20	the	the	DET
fnp-3806	4896	21	role	role	NOUN
fnp-3806	4896	22	of	of	ADP
fnp-3806	4896	23	lipid	lipid	ADJ
fnp-3806	4896	24	peroxidation	peroxidation	NOUN
fnp-3806	4896	25	in	in	ADP
fnp-3806	4896	26	the	the	DET
fnp-3806	4896	27	progression	progression	NOUN
fnp-3806	4896	28	and	and	CCONJ
fnp-3806	4896	29	pathogenesis	pathogenesis	NOUN
fnp-3806	4896	30	of	of	ADP
fnp-3806	4896	31	alzheimer	alzheimer	PROPN
fnp-3806	4896	32	’s	’s	PART
fnp-3806	4896	33	disease	disease	NOUN
fnp-3806	4896	34	.	.	PUNCT
fnp-3806	4897	1	neurobiol	neurobiol	PROPN
fnp-3806	4897	2	dis	dis	PROPN
fnp-3806	4897	3	2008;30:107	2008;30:107	PROPN
fnp-3806	4897	4	-	-	SYM
fnp-3806	4897	5	120	120	NUM
fnp-3806	4897	6	.	.	PUNCT
fnp-3806	4898	1	https://doi.org/10.1016/j.nbd.2007.12.007	https://doi.org/10.1016/j.nbd.2007.12.007	PROPN
fnp-3806	4898	2	.	.	PUNCT
fnp-3806	4899	1	reed	reed	PROPN
fnp-3806	4899	2	tt	tt	PROPN
fnp-3806	4899	3	,	,	PUNCT
fnp-3806	4899	4	pierce	pierce	PROPN
fnp-3806	4899	5	wm	wm	PROPN
fnp-3806	4899	6	jr	jr	PROPN
fnp-3806	4899	7	,	,	PUNCT
fnp-3806	4899	8	turner	turner	PROPN
fnp-3806	4899	9	dm	dm	PROPN
fnp-3806	4899	10	,	,	PUNCT
fnp-3806	4899	11	et	et	PROPN
fnp-3806	4899	12	al	al	PROPN
fnp-3806	4899	13	.	.	PROPN
fnp-3806	4899	14	proteomic	proteomic	ADJ
fnp-3806	4899	15	identification	identification	NOUN
fnp-3806	4899	16	of	of	ADP
fnp-3806	4899	17	nitrated	nitrated	ADJ
fnp-3806	4899	18	brain	brain	NOUN
fnp-3806	4899	19	proteins	protein	NOUN
fnp-3806	4899	20	in	in	ADP
fnp-3806	4899	21	early	early	ADJ
fnp-3806	4899	22	alzheimer	alzheimer	PROPN
fnp-3806	4899	23	’s	’s	PART
fnp-3806	4899	24	disease	disease	NOUN
fnp-3806	4899	25	inferior	inferior	ADJ
fnp-3806	4899	26	parietal	parietal	ADJ
fnp-3806	4899	27	lobule	lobule	NOUN
fnp-3806	4899	28	.	.	PUNCT
fnp-3806	4900	1	j	j	PROPN
fnp-3806	4900	2	cell	cell	NOUN
fnp-3806	4900	3	mol	mol	ADP
fnp-3806	4900	4	med	med	ADJ
fnp-3806	4900	5	2009;13:2019	2009;13:2019	NUM
fnp-3806	4900	6	-	-	SYM
fnp-3806	4900	7	2029	2029	NUM
fnp-3806	4900	8	.	.	PUNCT
fnp-3806	4901	1	https://doi.org/10.1111/j.1582-4934.2008.00478.x	https://doi.org/10.1111/j.1582-4934.2008.00478.x	ADJ
fnp-3806	4901	2	cabiscol	cabiscol	PROPN
fnp-3806	4901	3	e	e	PROPN
fnp-3806	4901	4	,	,	PUNCT
fnp-3806	4901	5	ros	ros	PROPN
fnp-3806	4901	6	j.	j.	PROPN
fnp-3806	4901	7	oxidative	oxidative	ADJ
fnp-3806	4901	8	damage	damage	NOUN
fnp-3806	4901	9	to	to	ADP
fnp-3806	4901	10	proteins	protein	NOUN
fnp-3806	4901	11	:	:	PUNCT
fnp-3806	4901	12	structural	structural	ADJ
fnp-3806	4901	13	modifications	modification	NOUN
fnp-3806	4901	14	and	and	CCONJ
fnp-3806	4901	15	consequences	consequence	NOUN
fnp-3806	4901	16	in	in	ADP
fnp-3806	4901	17	cell	cell	NOUN
fnp-3806	4901	18	function	function	NOUN
fnp-3806	4901	19	.	.	PUNCT
fnp-3806	4902	1	in	in	ADP
fnp-3806	4902	2	:	:	PUNCT
fnp-3806	4902	3	redox	redox	ADJ
fnp-3806	4902	4	proteomics	proteomic	NOUN
fnp-3806	4902	5	:	:	PUNCT
fnp-3806	4902	6	from	from	ADP
fnp-3806	4902	7	protein	protein	NOUN
fnp-3806	4902	8	modifications	modification	NOUN
fnp-3806	4902	9	to	to	ADP
fnp-3806	4902	10	cellular	cellular	ADJ
fnp-3806	4902	11	dysfunction	dysfunction	NOUN
fnp-3806	4902	12	and	and	CCONJ
fnp-3806	4902	13	diseases	disease	NOUN
fnp-3806	4902	14	.	.	PUNCT
fnp-3806	4903	1	i	i	PRON
fnp-3806	4903	2	dalle	dalle	NOUN
fnp-3806	4903	3	-	-	PUNCT
fnp-3806	4903	4	donne	donne	PROPN
fnp-3806	4903	5	,	,	PUNCT
fnp-3806	4903	6	a	a	DET
fnp-3806	4903	7	scaloni	scaloni	NOUN
fnp-3806	4903	8	,	,	PUNCT
fnp-3806	4903	9	da	da	PROPN
fnp-3806	4903	10	butterfield	butterfield	PROPN
fnp-3806	4903	11	(	(	PUNCT
fnp-3806	4903	12	eds	eds	PROPN
fnp-3806	4903	13	)	)	PUNCT
fnp-3806	4903	14	,	,	PUNCT
fnp-3806	4903	15	john	john	PROPN
fnp-3806	4903	16	wiley	wiley	PROPN
fnp-3806	4903	17	&	&	CCONJ
fnp-3806	4903	18	sons	sons	PROPN
fnp-3806	4903	19	:	:	PUNCT
fnp-3806	4903	20	hoboken	hoboken	PROPN
fnp-3806	4903	21	,	,	PUNCT
fnp-3806	4903	22	nj	nj	PROPN
fnp-3806	4903	23	.	.	PROPN
fnp-3806	4903	24	2006	2006	NUM
fnp-3806	4903	25	;	;	PUNCT
fnp-3806	4903	26	pp	pp	X
fnp-3806	4903	27	.	.	PUNCT
fnp-3806	4904	1	399	399	NUM
fnp-3806	4904	2	-	-	SYM
fnp-3806	4904	3	471	471	NUM
fnp-3806	4904	4	.	.	PUNCT
fnp-3806	4905	1	zabel	zabel	PROPN
fnp-3806	4905	2	m	m	PROPN
fnp-3806	4905	3	,	,	PUNCT
fnp-3806	4905	4	nackenoff	nackenoff	PROPN
fnp-3806	4905	5	a	a	PROPN
fnp-3806	4905	6	,	,	PUNCT
fnp-3806	4905	7	kirsch	kirsch	PROPN
fnp-3806	4905	8	wm	wm	PROPN
fnp-3806	4905	9	,	,	PUNCT
fnp-3806	4905	10	et	et	PROPN
fnp-3806	4905	11	al	al	PROPN
fnp-3806	4905	12	.	.	PUNCT
fnp-3806	4906	1	markers	marker	NOUN
fnp-3806	4906	2	of	of	ADP
fnp-3806	4906	3	oxidative	oxidative	ADJ
fnp-3806	4906	4	damage	damage	NOUN
fnp-3806	4906	5	to	to	ADP
fnp-3806	4906	6	lipids	lipid	NOUN
fnp-3806	4906	7	,	,	PUNCT
fnp-3806	4906	8	nucleic	nucleic	ADJ
fnp-3806	4906	9	acids	acid	NOUN
fnp-3806	4906	10	and	and	CCONJ
fnp-3806	4906	11	proteins	protein	NOUN
fnp-3806	4906	12	and	and	CCONJ
fnp-3806	4906	13	antioxidant	antioxidant	ADJ
fnp-3806	4906	14	enzymes	enzyme	NOUN
fnp-3806	4906	15	activities	activity	NOUN
fnp-3806	4906	16	in	in	ADP
fnp-3806	4906	17	alzheimer	alzheimer	PROPN
fnp-3806	4906	18	's	's	PART
fnp-3806	4906	19	disease	disease	NOUN
fnp-3806	4906	20	brain	brain	NOUN
fnp-3806	4906	21	:	:	PUNCT
fnp-3806	4906	22	a	a	DET
fnp-3806	4906	23	meta	meta	ADJ
fnp-3806	4906	24	-	-	PUNCT
fnp-3806	4906	25	analysis	analysis	NOUN
fnp-3806	4906	26	in	in	ADP
fnp-3806	4906	27	human	human	ADJ
fnp-3806	4906	28	pathological	pathological	ADJ
fnp-3806	4906	29	specimens	specimen	NOUN
fnp-3806	4906	30	.	.	PUNCT
fnp-3806	4907	1	free	free	ADJ
fnp-3806	4907	2	radic	radic	ADJ
fnp-3806	4907	3	biol	biol	PROPN
fnp-3806	4907	4	med	me	VERB
fnp-3806	4907	5	2018;115:351	2018;115:351	NOUN
fnp-3806	4907	6	-	-	SYM
fnp-3806	4907	7	360	360	NUM
fnp-3806	4907	8	.	.	PUNCT
fnp-3806	4908	1	https://doi.org/10.1016/j.freeradbiomed.2017.12.016	https://doi.org/10.1016/j.freeradbiomed.2017.12.016	PROPN
fnp-3806	4908	2	nunomura	nunomura	NOUN
fnp-3806	4908	3	a	a	NOUN
fnp-3806	4908	4	,	,	PUNCT
fnp-3806	4908	5	perry	perry	PROPN
fnp-3806	4908	6	g	g	PROPN
fnp-3806	4908	7	,	,	PUNCT
fnp-3806	4908	8	aliev	aliev	ADV
fnp-3806	4908	9	g	g	PROPN
fnp-3806	4908	10	,	,	PUNCT
fnp-3806	4908	11	et	et	PROPN
fnp-3806	4908	12	al	al	PROPN
fnp-3806	4908	13	.	.	PROPN
fnp-3806	4908	14	oxidative	oxidative	ADJ
fnp-3806	4908	15	damage	damage	NOUN
fnp-3806	4908	16	is	be	AUX
fnp-3806	4908	17	the	the	DET
fnp-3806	4908	18	earliest	early	ADJ
fnp-3806	4908	19	event	event	NOUN
fnp-3806	4908	20	in	in	ADP
fnp-3806	4908	21	alzheimer	alzheimer	PROPN
fnp-3806	4908	22	disease	disease	PROPN
fnp-3806	4908	23	.	.	PUNCT
fnp-3806	4909	1	j	j	PROPN
fnp-3806	4909	2	neuropathol	neuropathol	PROPN
fnp-3806	4909	3	exp	exp	PROPN
fnp-3806	4909	4	neurol	neurol	NOUN
fnp-3806	4909	5	2001;60:759	2001;60:759	PROPN
fnp-3806	4909	6	-	-	PUNCT
fnp-3806	4909	7	767	767	NUM
fnp-3806	4909	8	.	.	PUNCT
fnp-3806	4910	1	https://doi.org/10.1093/jnen/60.8.759	https://doi.org/10.1093/jnen/60.8.759	PRON
fnp-3806	4910	2	nunomura	nunomura	NOUN
fnp-3806	4910	3	a	a	PRON
fnp-3806	4910	4	,	,	PUNCT
fnp-3806	4910	5	castellani	castellani	PROPN
fnp-3806	4910	6	rj	rj	PROPN
fnp-3806	4910	7	,	,	PUNCT
fnp-3806	4910	8	zhu	zhu	PROPN
fnp-3806	4910	9	x	x	X
fnp-3806	4910	10	,	,	PUNCT
fnp-3806	4910	11	et	et	PROPN
fnp-3806	4910	12	al	al	PROPN
fnp-3806	4910	13	.	.	PUNCT
fnp-3806	4910	14	involvement	involvement	NOUN
fnp-3806	4910	15	of	of	ADP
fnp-3806	4910	16	oxidative	oxidative	ADJ
fnp-3806	4910	17	stress	stress	NOUN
fnp-3806	4910	18	in	in	ADP
fnp-3806	4910	19	alzheimer	alzheimer	PROPN
fnp-3806	4910	20	disease	disease	PROPN
fnp-3806	4910	21	.	.	PUNCT
fnp-3806	4911	1	j	j	PROPN
fnp-3806	4911	2	neuropathol	neuropathol	PROPN
fnp-3806	4911	3	exp	exp	PROPN
fnp-3806	4911	4	neurol	neurol	PROPN
fnp-3806	4911	5	2006;65:631	2006;65:631	NUM
fnp-3806	4911	6	-	-	PUNCT
fnp-3806	4911	7	641	641	NUM
fnp-3806	4911	8	.	.	PUNCT
fnp-3806	4912	1	https://doi.org/10.1097/01.jnen.0000228136.58062.bf	https://doi.org/10.1097/01.jnen.0000228136.58062.bf	NOUN
fnp-3806	4912	2	nunomura	nunomura	NOUN
fnp-3806	4912	3	a	a	NOUN
fnp-3806	4912	4	,	,	PUNCT
fnp-3806	4912	5	perry	perry	PROPN
fnp-3806	4912	6	g	g	PROPN
fnp-3806	4912	7	,	,	PUNCT
fnp-3806	4912	8	pappolla	pappolla	PROPN
fnp-3806	4912	9	ma	ma	PROPN
fnp-3806	4912	10	,	,	PUNCT
fnp-3806	4912	11	et	et	PROPN
fnp-3806	4912	12	al	al	PROPN
fnp-3806	4912	13	.	.	PUNCT
fnp-3806	4913	1	neuronal	neuronal	ADJ
fnp-3806	4913	2	oxidative	oxidative	ADJ
fnp-3806	4913	3	stress	stress	NOUN
fnp-3806	4913	4	precedes	precede	VERB
fnp-3806	4913	5	amyloid	amyloid	NOUN
fnp-3806	4913	6	-	-	PUNCT
fnp-3806	4913	7	beta	beta	ADJ
fnp-3806	4913	8	deposition	deposition	NOUN
fnp-3806	4913	9	in	in	ADP
fnp-3806	4913	10	down	down	ADP
fnp-3806	4913	11	syndrome	syndrome	NOUN
fnp-3806	4913	12	.	.	PUNCT
fnp-3806	4914	1	j	j	PROPN
fnp-3806	4914	2	neuropathol	neuropathol	PROPN
fnp-3806	4914	3	exp	exp	PROPN
fnp-3806	4914	4	neurol	neurol	PROPN
fnp-3806	4914	5	2000;59:1011	2000;59:1011	NUM
fnp-3806	4914	6	-	-	SYM
fnp-3806	4914	7	1017	1017	NUM
fnp-3806	4914	8	.	.	PUNCT
fnp-3806	4915	1	https://doi.org/10.1093/jnen/59.11.1011	https://doi.org/10.1093/jnen/59.11.1011	X
fnp-3806	4916	1	nunomura	nunomura	NOUN
fnp-3806	4916	2	a	a	NOUN
fnp-3806	4916	3	,	,	PUNCT
fnp-3806	4916	4	chiba	chiba	PROPN
fnp-3806	4916	5	s	s	PROPN
fnp-3806	4916	6	,	,	PUNCT
fnp-3806	4916	7	lippa	lippa	ADJ
fnp-3806	4916	8	cf	cf	NOUN
fnp-3806	4916	9	,	,	PUNCT
fnp-3806	4916	10	et	et	PROPN
fnp-3806	4916	11	al	al	PROPN
fnp-3806	4916	12	.	.	PUNCT
fnp-3806	4916	13	neuronal	neuronal	ADJ
fnp-3806	4916	14	rna	rna	PROPN
fnp-3806	4916	15	oxidation	oxidation	NOUN
fnp-3806	4916	16	is	be	AUX
fnp-3806	4916	17	a	a	DET
fnp-3806	4916	18	prominent	prominent	ADJ
fnp-3806	4916	19	feature	feature	NOUN
fnp-3806	4916	20	of	of	ADP
fnp-3806	4916	21	familial	familial	ADJ
fnp-3806	4916	22	alzheimer	alzheimer	NOUN
fnp-3806	4916	23	's	's	PART
fnp-3806	4916	24	disease	disease	NOUN
fnp-3806	4916	25	.	.	PUNCT
fnp-3806	4917	1	neurobiol	neurobiol	PROPN
fnp-3806	4917	2	dis	dis	PROPN
fnp-3806	4917	3	2004;17:108	2004;17:108	PROPN
fnp-3806	4917	4	-	-	PUNCT
fnp-3806	4917	5	113	113	NUM
fnp-3806	4917	6	.	.	PUNCT
fnp-3806	4918	1	https://doi.org/10.1016/j.nbd.2004.06.003	https://doi.org/10.1016/j.nbd.2004.06.003	PROPN
fnp-3806	4918	2	smith	smith	PROPN
fnp-3806	4918	3	ma	ma	PROPN
fnp-3806	4918	4	,	,	PUNCT
fnp-3806	4918	5	sayre	sayre	PROPN
fnp-3806	4918	6	lm	lm	PROPN
fnp-3806	4918	7	,	,	PUNCT
fnp-3806	4918	8	monnier	monnier	PROPN
fnp-3806	4918	9	vm	vm	PROPN
fnp-3806	4918	10	,	,	PUNCT
fnp-3806	4918	11	et	et	PROPN
fnp-3806	4918	12	al	al	PROPN
fnp-3806	4918	13	.	.	PROPN
fnp-3806	4918	14	oxidative	oxidative	ADJ
fnp-3806	4918	15	posttranslational	posttranslational	ADJ
fnp-3806	4918	16	modifications	modification	NOUN
fnp-3806	4918	17	in	in	ADP
fnp-3806	4918	18	alzheimer	alzheimer	PROPN
fnp-3806	4918	19	disease	disease	PROPN
fnp-3806	4918	20	.	.	PUNCT
fnp-3806	4919	1	a	a	DET
fnp-3806	4919	2	possible	possible	ADJ
fnp-3806	4919	3	pathogenic	pathogenic	ADJ
fnp-3806	4919	4	role	role	NOUN
fnp-3806	4919	5	in	in	ADP
fnp-3806	4919	6	the	the	DET
fnp-3806	4919	7	formation	formation	NOUN
fnp-3806	4919	8	of	of	ADP
fnp-3806	4919	9	senile	senile	ADJ
fnp-3806	4919	10	plaques	plaque	NOUN
fnp-3806	4919	11	and	and	CCONJ
fnp-3806	4919	12	neurofibrillary	neurofibrillary	ADJ
fnp-3806	4919	13	tangles	tangle	NOUN
fnp-3806	4919	14	.	.	PUNCT
fnp-3806	4920	1	mol	mol	ADP
fnp-3806	4920	2	chem	chem	NOUN
fnp-3806	4920	3	neuropathol	neuropathol	NOUN
fnp-3806	4920	4	1996;28:41	1996;28:41	NUM
fnp-3806	4920	5	-	-	SYM
fnp-3806	4920	6	48	48	NUM
fnp-3806	4920	7	.	.	PUNCT
fnp-3806	4921	1	https://doi.org/10.1007/bf02815203	https://doi.org/10.1007/bf02815203	NOUN
fnp-3806	4921	2	nunomura	nunomura	PROPN
fnp-3806	4921	3	a	a	NOUN
fnp-3806	4921	4	,	,	PUNCT
fnp-3806	4921	5	honda	honda	PROPN
fnp-3806	4921	6	k	k	PROPN
fnp-3806	4921	7	,	,	PUNCT
fnp-3806	4921	8	takeda	takeda	PROPN
fnp-3806	4921	9	a	a	X
fnp-3806	4921	10	,	,	PUNCT
fnp-3806	4921	11	et	et	PROPN
fnp-3806	4921	12	al	al	PROPN
fnp-3806	4921	13	.	.	PROPN
fnp-3806	4921	14	oxidative	oxidative	ADJ
fnp-3806	4921	15	damage	damage	NOUN
fnp-3806	4921	16	to	to	ADP
fnp-3806	4921	17	rna	rna	NOUN
fnp-3806	4921	18	in	in	ADP
fnp-3806	4921	19	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4921	20	diseases	disease	NOUN
fnp-3806	4921	21	.	.	PUNCT
fnp-3806	4922	1	j	j	PROPN
fnp-3806	4922	2	biomed	biome	VERB
fnp-3806	4922	3	biotechnol	biotechnol	NOUN
fnp-3806	4922	4	2006;2006	2006;2006	NOUN
fnp-3806	4922	5	:	:	PUNCT
fnp-3806	4922	6	82323	82323	NUM
fnp-3806	4922	7	.	.	PUNCT
fnp-3806	4923	1	https://doi.org/10.1155/jbb/2006/82323	https://doi.org/10.1155/jbb/2006/82323	NOUN
fnp-3806	4923	2	tamagno	tamagno	NOUN
fnp-3806	4923	3	e	e	NOUN
fnp-3806	4923	4	,	,	PUNCT
fnp-3806	4923	5	guglielmotto	guglielmotto	NOUN
fnp-3806	4923	6	m	m	PROPN
fnp-3806	4923	7	,	,	PUNCT
fnp-3806	4923	8	vasciaveo	vasciaveo	VERB
fnp-3806	4923	9	v	v	ADP
fnp-3806	4923	10	,	,	PUNCT
fnp-3806	4923	11	et	et	PROPN
fnp-3806	4923	12	al	al	PROPN
fnp-3806	4923	13	.	.	PROPN
fnp-3806	4923	14	oxidative	oxidative	ADJ
fnp-3806	4923	15	stress	stress	NOUN
fnp-3806	4923	16	and	and	CCONJ
fnp-3806	4923	17	betaamyloid	betaamyloid	VERB
fnp-3806	4923	18	in	in	ADP
fnp-3806	4923	19	alzheimer	alzheimer	PROPN
fnp-3806	4923	20	's	's	PART
fnp-3806	4923	21	disease	disease	NOUN
fnp-3806	4923	22	.	.	PUNCT
fnp-3806	4924	1	which	which	PRON
fnp-3806	4924	2	comes	come	VERB
fnp-3806	4924	3	first	first	ADV
fnp-3806	4924	4	:	:	PUNCT
fnp-3806	4924	5	the	the	DET
fnp-3806	4924	6	chicken	chicken	NOUN
fnp-3806	4924	7	or	or	CCONJ
fnp-3806	4924	8	the	the	DET
fnp-3806	4924	9	egg	egg	NOUN
fnp-3806	4924	10	?	?	PUNCT
fnp-3806	4925	1	antioxidants	antioxidant	NOUN
fnp-3806	4925	2	2021;10:1479	2021;10:1479	NUM
fnp-3806	4925	3	.	.	PUNCT
fnp-3806	4926	1	https://doi.org/10.3390/antiox10091479	https://doi.org/10.3390/antiox10091479	PROPN
fnp-3806	4926	2	wang	wang	PROPN
fnp-3806	4926	3	x	x	PROPN
fnp-3806	4926	4	,	,	PUNCT
fnp-3806	4926	5	wang	wang	PROPN
fnp-3806	4926	6	w	w	PROPN
fnp-3806	4926	7	,	,	PUNCT
fnp-3806	4926	8	li	li	PROPN
fnp-3806	4926	9	l	l	PROPN
fnp-3806	4926	10	,	,	PUNCT
fnp-3806	4926	11	et	et	PROPN
fnp-3806	4926	12	al	al	PROPN
fnp-3806	4926	13	.	.	PROPN
fnp-3806	4926	14	oxidative	oxidative	ADJ
fnp-3806	4926	15	stress	stress	NOUN
fnp-3806	4926	16	and	and	CCONJ
fnp-3806	4926	17	mitochondrial	mitochondrial	ADJ
fnp-3806	4926	18	dysfunction	dysfunction	NOUN
fnp-3806	4926	19	in	in	ADP
fnp-3806	4926	20	alzheimer	alzheimer	PROPN
fnp-3806	4926	21	’s	’s	PART
fnp-3806	4926	22	disease	disease	NOUN
fnp-3806	4926	23	.	.	PUNCT
fnp-3806	4927	1	biochim	biochim	PROPN
fnp-3806	4927	2	biophys	biophy	NOUN
fnp-3806	4927	3	acta	acta	PROPN
fnp-3806	4927	4	2014	2014	NUM
fnp-3806	4927	5	;	;	PUNCT
fnp-3806	4927	6	1842:1240	1842:1240	NUM
fnp-3806	4927	7	-	-	SYM
fnp-3806	4927	8	1247	1247	NUM
fnp-3806	4927	9	.	.	PUNCT
fnp-3806	4928	1	https://doi.org/10.1016/j.bbadis.2013.10.015	https://doi.org/10.1016/j.bbadis.2013.10.015	PROPN
fnp-3806	4928	2	jové	jové	PROPN
fnp-3806	4928	3	m	m	PROPN
fnp-3806	4928	4	,	,	PUNCT
fnp-3806	4928	5	pradas	pradas	PROPN
fnp-3806	4928	6	i	i	PROPN
fnp-3806	4928	7	,	,	PUNCT
fnp-3806	4928	8	dominguez	dominguez	PROPN
fnp-3806	4928	9	-	-	PUNCT
fnp-3806	4928	10	gonzalez	gonzalez	PROPN
fnp-3806	4928	11	m	m	PROPN
fnp-3806	4928	12	,	,	PUNCT
fnp-3806	4928	13	et	et	PROPN
fnp-3806	4928	14	al	al	PROPN
fnp-3806	4928	15	.	.	PROPN
fnp-3806	4929	1	lipids	lipids	PROPN
fnp-3806	4929	2	and	and	CCONJ
fnp-3806	4929	3	lipoxidation	lipoxidation	NOUN
fnp-3806	4929	4	in	in	ADP
fnp-3806	4929	5	human	human	ADJ
fnp-3806	4929	6	brain	brain	NOUN
fnp-3806	4929	7	aging	aging	NOUN
fnp-3806	4929	8	.	.	PUNCT
fnp-3806	4930	1	mitochondrial	mitochondrial	ADJ
fnp-3806	4930	2	atp	atp	NOUN
fnp-3806	4930	3	-	-	PUNCT
fnp-3806	4930	4	synthase	synthase	NOUN
fnp-3806	4930	5	as	as	ADP
fnp-3806	4930	6	a	a	DET
fnp-3806	4930	7	key	key	ADJ
fnp-3806	4930	8	lipoxidation	lipoxidation	NOUN
fnp-3806	4930	9	target	target	NOUN
fnp-3806	4930	10	.	.	PUNCT
fnp-3806	4931	1	redox	redox	ADJ
fnp-3806	4931	2	biol	biol	PROPN
fnp-3806	4931	3	2019;23:101082	2019;23:101082	PROPN
fnp-3806	4931	4	.	.	PUNCT
fnp-3806	4932	1	https://doi.org/10.1016/j.redox.2018.101082	https://doi.org/10.1016/j.redox.2018.101082	ADJ
fnp-3806	4932	2	jové	jové	PROPN
fnp-3806	4932	3	m	m	PROPN
fnp-3806	4932	4	,	,	PUNCT
fnp-3806	4932	5	mota	mota	NOUN
fnp-3806	4932	6	-	-	PUNCT
fnp-3806	4932	7	martorell	martorell	NOUN
fnp-3806	4932	8	n	n	CCONJ
fnp-3806	4932	9	,	,	PUNCT
fnp-3806	4932	10	torres	torre	VERB
fnp-3806	4932	11	p	p	X
fnp-3806	4932	12	,	,	PUNCT
fnp-3806	4932	13	et	et	PROPN
fnp-3806	4932	14	al	al	PROPN
fnp-3806	4932	15	.	.	PUNCT
fnp-3806	4933	1	the	the	DET
fnp-3806	4933	2	causal	causal	ADJ
fnp-3806	4933	3	role	role	NOUN
fnp-3806	4933	4	of	of	ADP
fnp-3806	4933	5	lipoxidative	lipoxidative	ADJ
fnp-3806	4933	6	damage	damage	NOUN
fnp-3806	4933	7	in	in	ADP
fnp-3806	4933	8	mitochondrial	mitochondrial	ADJ
fnp-3806	4933	9	bioenergetic	bioenergetic	ADJ
fnp-3806	4933	10	dysfunction	dysfunction	NOUN
fnp-3806	4933	11	linked	link	VERB
fnp-3806	4933	12	to	to	ADP
fnp-3806	4933	13	alzheimer	alzheimer	PROPN
fnp-3806	4933	14	's	's	PART
fnp-3806	4933	15	disease	disease	NOUN
fnp-3806	4933	16	pathology	pathology	NOUN
fnp-3806	4933	17	.	.	PUNCT
fnp-3806	4934	1	life	life	NOUN
fnp-3806	4934	2	2021;11:388	2021;11:388	NUM
fnp-3806	4934	3	.	.	PUNCT
fnp-3806	4935	1	https://doi.org/10.3390/life11050388	https://doi.org/10.3390/life11050388	PROPN
fnp-3806	4935	2	ferrer	ferrer	PROPN
fnp-3806	4935	3	i.	i.	PROPN
fnp-3806	4935	4	altered	alter	VERB
fnp-3806	4935	5	mitochondria	mitochondria	PROPN
fnp-3806	4935	6	,	,	PUNCT
fnp-3806	4935	7	energy	energy	NOUN
fnp-3806	4935	8	metabolism	metabolism	NOUN
fnp-3806	4935	9	,	,	PUNCT
fnp-3806	4935	10	voltage	voltage	NOUN
fnp-3806	4935	11	-	-	PUNCT
fnp-3806	4935	12	dependent	dependent	ADJ
fnp-3806	4935	13	anion	anion	NOUN
fnp-3806	4935	14	channel	channel	NOUN
fnp-3806	4935	15	,	,	PUNCT
fnp-3806	4935	16	and	and	CCONJ
fnp-3806	4935	17	lipid	lipid	NOUN
fnp-3806	4935	18	rafts	raft	NOUN
fnp-3806	4935	19	converge	converge	VERB
fnp-3806	4935	20	to	to	ADP
fnp-3806	4935	21	exhaust	exhaust	NOUN
fnp-3806	4935	22	neurons	neuron	NOUN
fnp-3806	4935	23	in	in	ADP
fnp-3806	4935	24	alzheimer	alzheimer	PROPN
fnp-3806	4935	25	's	's	PART
fnp-3806	4935	26	disease	disease	NOUN
fnp-3806	4935	27	.	.	PUNCT
fnp-3806	4936	1	j	j	PROPN
fnp-3806	4936	2	bioenerg	bioenerg	PROPN
fnp-3806	4936	3	biomembr	biomembr	VERB
fnp-3806	4936	4	2009;41:425	2009;41:425	NUM
fnp-3806	4936	5	-	-	SYM
fnp-3806	4936	6	431	431	NUM
fnp-3806	4936	7	.	.	PUNCT
fnp-3806	4937	1	https://doi.org/10.1007/s10863-009-9243-5	https://doi.org/10.1007/s10863-009-9243-5	NUM
fnp-3806	4937	2	münch	münch	NOUN
fnp-3806	4937	3	g	g	NOUN
fnp-3806	4937	4	,	,	PUNCT
fnp-3806	4937	5	gasic	gasic	NOUN
fnp-3806	4937	6	-	-	PUNCT
fnp-3806	4937	7	milenkovic	milenkovic	ADJ
fnp-3806	4937	8	j	j	PROPN
fnp-3806	4937	9	,	,	PUNCT
fnp-3806	4937	10	arendt	arendt	PROPN
fnp-3806	4937	11	t.	t.	PROPN
fnp-3806	4937	12	effect	effect	NOUN
fnp-3806	4937	13	of	of	ADP
fnp-3806	4937	14	advanced	advanced	ADJ
fnp-3806	4937	15	glycation	glycation	NOUN
fnp-3806	4937	16	endproducts	endproduct	NOUN
fnp-3806	4937	17	on	on	ADP
fnp-3806	4937	18	cell	cell	NOUN
fnp-3806	4937	19	cycle	cycle	NOUN
fnp-3806	4937	20	and	and	CCONJ
fnp-3806	4937	21	their	their	PRON
fnp-3806	4937	22	relevance	relevance	NOUN
fnp-3806	4937	23	for	for	ADP
fnp-3806	4937	24	alzheimer	alzheimer	PROPN
fnp-3806	4937	25	's	's	PART
fnp-3806	4937	26	disease	disease	NOUN
fnp-3806	4937	27	.	.	PUNCT
fnp-3806	4938	1	j	j	PROPN
fnp-3806	4938	2	neural	neural	PROPN
fnp-3806	4938	3	transm	transm	PROPN
fnp-3806	4938	4	suppl	suppl	ADJ
fnp-3806	4938	5	2003;65:63	2003;65:63	NUM
fnp-3806	4938	6	-	-	SYM
fnp-3806	4938	7	71	71	NUM
fnp-3806	4938	8	.	.	PUNCT
fnp-3806	4939	1	https://doi.org/10.1007/978-3-7091-0643-3_4	https://doi.org/10.1007/978-3-7091-0643-3_4	PROPN
fnp-3806	4939	2	yankner	yankner	NOUN
fnp-3806	4939	3	ba	ba	PROPN
fnp-3806	4939	4	,	,	PUNCT
fnp-3806	4939	5	lu	lu	PROPN
fnp-3806	4939	6	t	t	PROPN
fnp-3806	4939	7	,	,	PUNCT
fnp-3806	4939	8	loerch	loerch	PROPN
fnp-3806	4939	9	p.	p.	PROPN
fnp-3806	4939	10	the	the	DET
fnp-3806	4939	11	aging	age	VERB
fnp-3806	4939	12	brain	brain	NOUN
fnp-3806	4939	13	.	.	PUNCT
fnp-3806	4940	1	annu	annu	PROPN
fnp-3806	4940	2	rev	rev	PROPN
fnp-3806	4940	3	pathol	pathol	PROPN
fnp-3806	4940	4	2008;3:41	2008;3:41	NOUN
fnp-3806	4940	5	-	-	PUNCT
fnp-3806	4940	6	66	66	NUM
fnp-3806	4940	7	.	.	PUNCT
fnp-3806	4941	1	https://www.doi.org/10.1146/annurev.pathmechdis.2.010506.092044	https://www.doi.org/10.1146/annurev.pathmechdis.2.010506.092044	PROPN
fnp-3806	4941	2	lucin	lucin	PROPN
fnp-3806	4941	3	km	km	PROPN
fnp-3806	4941	4	,	,	PUNCT
fnp-3806	4941	5	wyss	wyss	NOUN
fnp-3806	4941	6	-	-	PUNCT
fnp-3806	4941	7	coray	coray	NOUN
fnp-3806	4941	8	t.	t.	NOUN
fnp-3806	4941	9	immune	immune	ADJ
fnp-3806	4941	10	activation	activation	NOUN
fnp-3806	4941	11	in	in	ADP
fnp-3806	4941	12	brain	brain	NOUN
fnp-3806	4941	13	aging	aging	NOUN
fnp-3806	4941	14	and	and	CCONJ
fnp-3806	4941	15	neurodegeneration	neurodegeneration	NOUN
fnp-3806	4941	16	:	:	PUNCT
fnp-3806	4941	17	too	too	ADV
fnp-3806	4941	18	much	much	ADJ
fnp-3806	4941	19	or	or	CCONJ
fnp-3806	4941	20	too	too	ADV
fnp-3806	4941	21	little	little	ADJ
fnp-3806	4941	22	?	?	PUNCT
fnp-3806	4941	23	neuron	neuron	PROPN
fnp-3806	4942	1	2009;64:110	2009;64:110	PROPN
fnp-3806	4942	2	-	-	SYM
fnp-3806	4942	3	122	122	NUM
fnp-3806	4942	4	.	.	PUNCT
fnp-3806	4943	1	https://doi.org/10.1016/j.neuron.2009.08.039	https://doi.org/10.1016/j.neuron.2009.08.039	NOUN
fnp-3806	4943	2	jenkinson	jenkinson	PROPN
fnp-3806	4943	3	ml	ml	PROPN
fnp-3806	4943	4	,	,	PUNCT
fnp-3806	4943	5	bliss	bliss	PROPN
fnp-3806	4943	6	mr	mr	PROPN
fnp-3806	4943	7	,	,	PUNCT
fnp-3806	4943	8	brain	brain	NOUN
fnp-3806	4943	9	at	at	ADP
fnp-3806	4943	10	,	,	PUNCT
fnp-3806	4943	11	scott	scott	PROPN
fnp-3806	4943	12	dl	dl	AUX
fnp-3806	4943	13	.	.	PROPN
fnp-3806	4943	14	rheumatoid	rheumatoid	VERB
fnp-3806	4943	15	arthritis	arthritis	NOUN
fnp-3806	4943	16	and	and	CCONJ
fnp-3806	4943	17	senile	senile	ADJ
fnp-3806	4943	18	dementia	dementia	NOUN
fnp-3806	4943	19	of	of	ADP
fnp-3806	4943	20	the	the	DET
fnp-3806	4943	21	alzheimer	alzheimer	PROPN
fnp-3806	4943	22	’s	’s	PART
fnp-3806	4943	23	type	type	NOUN
fnp-3806	4943	24	.	.	PUNCT
fnp-3806	4944	1	br	br	PROPN
fnp-3806	4944	2	j	j	PROPN
fnp-3806	4944	3	rheumatol	rheumatol	VERB
fnp-3806	4944	4	1989;28:86	1989;28:86	NUM
fnp-3806	4944	5	-	-	SYM
fnp-3806	4944	6	88	88	NUM
fnp-3806	4944	7	.	.	PUNCT
fnp-3806	4945	1	https://doi.org/10.1093/rheumatology/28.1.86-b	https://doi.org/10.1093/rheumatology/28.1.86-b	PROPN
fnp-3806	4945	2	mcgeer	mcgeer	PROPN
fnp-3806	4945	3	pl	pl	PROPN
fnp-3806	4945	4	,	,	PUNCT
fnp-3806	4945	5	mcgeer	mcgeer	PROPN
fnp-3806	4945	6	e	e	PROPN
fnp-3806	4945	7	,	,	PUNCT
fnp-3806	4945	8	rogers	rogers	PROPN
fnp-3806	4945	9	j	j	PROPN
fnp-3806	4945	10	,	,	PUNCT
fnp-3806	4945	11	sibley	sibley	PROPN
fnp-3806	4945	12	j.	j.	PROPN
fnp-3806	4945	13	anti	anti	ADJ
fnp-3806	4945	14	-	-	ADJ
fnp-3806	4945	15	inflammatory	inflammatory	ADJ
fnp-3806	4945	16	drugs	drug	NOUN
fnp-3806	4945	17	and	and	CCONJ
fnp-3806	4945	18	alzheimer	alzheimer	PROPN
fnp-3806	4945	19	disease	disease	NOUN
fnp-3806	4945	20	.	.	PUNCT
fnp-3806	4946	1	lancet	lancet	PROPN
fnp-3806	4946	2	1990;335:1037	1990;335:1037	NUM
fnp-3806	4946	3	.	.	PUNCT
fnp-3806	4947	1	https://doi.org/10.1016/0140-6736(90)91101-f	https://doi.org/10.1016/0140-6736(90)91101-f	ADJ
fnp-3806	4947	2	myllykangas	myllykanga	NOUN
fnp-3806	4947	3	-	-	PUNCT
fnp-3806	4947	4	luosujarvi	luosujarvi	ADJ
fnp-3806	4947	5	r	r	NOUN
fnp-3806	4947	6	,	,	PUNCT
fnp-3806	4947	7	isomaki	isomaki	PROPN
fnp-3806	4947	8	h.	h.	PROPN
fnp-3806	4947	9	alzheimer	alzheimer	PROPN
fnp-3806	4947	10	’s	’s	PART
fnp-3806	4947	11	disease	disease	NOUN
fnp-3806	4947	12	and	and	CCONJ
fnp-3806	4947	13	rheumatoid	rheumatoid	VERB
fnp-3806	4947	14	arthritis	arthritis	NOUN
fnp-3806	4947	15	.	.	PUNCT
fnp-3806	4948	1	br	br	PROPN
fnp-3806	4948	2	j	j	PROPN
fnp-3806	4948	3	rheumatol	rheumatol	PROPN
fnp-3806	4948	4	1994;33:501	1994;33:501	VERB
fnp-3806	4948	5	-	-	SYM
fnp-3806	4948	6	502	502	NUM
fnp-3806	4948	7	.	.	PUNCT
fnp-3806	4949	1	https://doi.org/10.1093/rheumatology/33.5.501	https://doi.org/10.1093/rheumatology/33.5.501	NUM
fnp-3806	4949	2	breitner	breitner	NOUN
fnp-3806	4949	3	jc	jc	PROPN
fnp-3806	4949	4	,	,	PUNCT
fnp-3806	4949	5	welsh	welsh	PROPN
fnp-3806	4949	6	ka	ka	PROPN
fnp-3806	4949	7	,	,	PUNCT
fnp-3806	4949	8	helms	helms	PROPN
fnp-3806	4949	9	mj	mj	PROPN
fnp-3806	4949	10	,	,	PUNCT
fnp-3806	4949	11	et	et	PROPN
fnp-3806	4949	12	al	al	PROPN
fnp-3806	4949	13	.	.	PROPN
fnp-3806	4949	14	delayed	delay	VERB
fnp-3806	4949	15	onset	onset	NOUN
fnp-3806	4949	16	of	of	ADP
fnp-3806	4949	17	alzheimer	alzheimer	PROPN
fnp-3806	4949	18	’s	’s	PART
fnp-3806	4949	19	disease	disease	NOUN
fnp-3806	4949	20	with	with	ADP
fnp-3806	4949	21	non	non	ADJ
fnp-3806	4949	22	-	-	ADJ
fnp-3806	4949	23	steroidal	steroidal	ADJ
fnp-3806	4949	24	anti	anti	ADJ
fnp-3806	4949	25	-	-	ADJ
fnp-3806	4949	26	inflammatory	inflammatory	ADJ
fnp-3806	4949	27	and	and	CCONJ
fnp-3806	4949	28	histamine	histamine	NOUN
fnp-3806	4949	29	h2	h2	NOUN
fnp-3806	4949	30	blocking	block	VERB
fnp-3806	4949	31	drugs	drug	NOUN
fnp-3806	4949	32	.	.	PUNCT
fnp-3806	4950	1	neurobiol	neurobiol	ADJ
fnp-3806	4950	2	aging	age	VERB
fnp-3806	4950	3	1995;16:523	1995;16:523	NUM
fnp-3806	4950	4	-	-	SYM
fnp-3806	4950	5	530	530	NUM
fnp-3806	4950	6	.	.	PUNCT
fnp-3806	4951	1	https://doi.org/10.1016/0197-4580(95)00049-k	https://doi.org/10.1016/0197-4580(95)00049-k	NOUN
fnp-3806	4951	2	stewart	stewart	PROPN
fnp-3806	4951	3	wf	wf	PROPN
fnp-3806	4951	4	,	,	PUNCT
fnp-3806	4951	5	kawas	kawa	VERB
fnp-3806	4951	6	c	c	NOUN
fnp-3806	4951	7	,	,	PUNCT
fnp-3806	4951	8	corrada	corrada	PROPN
fnp-3806	4951	9	m	m	PROPN
fnp-3806	4951	10	,	,	PUNCT
fnp-3806	4951	11	et	et	PROPN
fnp-3806	4951	12	al	al	PROPN
fnp-3806	4951	13	.	.	PROPN
fnp-3806	4951	14	risk	risk	NOUN
fnp-3806	4951	15	of	of	ADP
fnp-3806	4951	16	alzheimer	alzheimer	PROPN
fnp-3806	4951	17	’s	’s	PART
fnp-3806	4951	18	disease	disease	NOUN
fnp-3806	4951	19	and	and	CCONJ
fnp-3806	4951	20	duration	duration	NOUN
fnp-3806	4951	21	of	of	ADP
fnp-3806	4951	22	nsaid	nsaid	PROPN
fnp-3806	4951	23	use	use	PROPN
fnp-3806	4951	24	.	.	PUNCT
fnp-3806	4952	1	neurology	neurology	NOUN
fnp-3806	4952	2	1997;48:626	1997;48:626	PROPN
fnp-3806	4952	3	-	-	NUM
fnp-3806	4952	4	632	632	NUM
fnp-3806	4952	5	.	.	PUNCT
fnp-3806	4953	1	https://doi.org/10.1212/wnl.48.3.626	https://doi.org/10.1212/wnl.48.3.626	PROPN
fnp-3806	4953	2	mackenzie	mackenzie	PROPN
fnp-3806	4953	3	ira	ira	PROPN
fnp-3806	4953	4	,	,	PUNCT
fnp-3806	4953	5	muñoz	muñoz	PROPN
fnp-3806	4953	6	dg	dg	PROPN
fnp-3806	4953	7	.	.	PUNCT
fnp-3806	4954	1	nonsteroidal	nonsteroidal	NOUN
fnp-3806	4954	2	anti	anti	ADJ
fnp-3806	4954	3	-	-	ADJ
fnp-3806	4954	4	inflammatory	inflammatory	ADJ
fnp-3806	4954	5	drug	drug	NOUN
fnp-3806	4954	6	use	use	NOUN
fnp-3806	4954	7	and	and	CCONJ
fnp-3806	4954	8	alzheimer	alzheimer	ADJ
fnp-3806	4954	9	-	-	PUNCT
fnp-3806	4954	10	type	type	NOUN
fnp-3806	4954	11	pathology	pathology	NOUN
fnp-3806	4954	12	in	in	ADP
fnp-3806	4954	13	aging	aging	NOUN
fnp-3806	4954	14	.	.	PUNCT
fnp-3806	4955	1	neurology	neurology	NOUN
fnp-3806	4955	2	1998;50:986	1998;50:986	PROPN
fnp-3806	4955	3	-	-	SYM
fnp-3806	4955	4	990	990	NUM
fnp-3806	4955	5	.	.	PUNCT
fnp-3806	4956	1	https://doi.org/10.1212/wnl.50.4.986	https://doi.org/10.1212/wnl.50.4.986	PROPN
fnp-3806	4956	2	zandi	zandi	NOUN
fnp-3806	4956	3	pp	pp	PROPN
fnp-3806	4956	4	,	,	PUNCT
fnp-3806	4956	5	anthony	anthony	PROPN
fnp-3806	4956	6	jc	jc	PROPN
fnp-3806	4956	7	,	,	PUNCT
fnp-3806	4956	8	hayden	hayden	PROPN
fnp-3806	4956	9	km	km	PROPN
fnp-3806	4956	10	,	,	PUNCT
fnp-3806	4956	11	et	et	PROPN
fnp-3806	4956	12	al	al	PROPN
fnp-3806	4956	13	.	.	PROPN
fnp-3806	4957	1	reduced	reduce	VERB
fnp-3806	4957	2	incidence	incidence	NOUN
fnp-3806	4957	3	of	of	ADP
fnp-3806	4957	4	ad	ad	NOUN
fnp-3806	4957	5	with	with	ADP
fnp-3806	4957	6	nsaid	nsaid	PROPN
fnp-3806	4957	7	but	but	CCONJ
fnp-3806	4957	8	not	not	PART
fnp-3806	4957	9	h2	h2	NOUN
fnp-3806	4957	10	receptor	receptor	NOUN
fnp-3806	4957	11	antagonists	antagonist	NOUN
fnp-3806	4957	12	:	:	PUNCT
fnp-3806	4957	13	the	the	DET
fnp-3806	4957	14	cache	cache	PROPN
fnp-3806	4957	15	county	county	PROPN
fnp-3806	4957	16	study	study	NOUN
fnp-3806	4957	17	.	.	PUNCT
fnp-3806	4958	1	neurology	neurology	NOUN
fnp-3806	4958	2	2002;59:880	2002;59:880	PROPN
fnp-3806	4958	3	-	-	PUNCT
fnp-3806	4958	4	886	886	NUM
fnp-3806	4958	5	.	.	PUNCT
fnp-3806	4959	1	https://doi.org/10.1212/wnl.59.6.880	https://doi.org/10.1212/wnl.59.6.880	PROPN
fnp-3806	4959	2	vlad	vlad	PROPN
fnp-3806	4959	3	sc	sc	PROPN
fnp-3806	4959	4	,	,	PUNCT
fnp-3806	4959	5	miller	miller	PROPN
fnp-3806	4959	6	dr	dr	PROPN
fnp-3806	4959	7	,	,	PUNCT
fnp-3806	4959	8	kowall	kowall	PROPN
fnp-3806	4959	9	nw	nw	PROPN
fnp-3806	4959	10	,	,	PUNCT
fnp-3806	4959	11	et	et	PROPN
fnp-3806	4959	12	al	al	PROPN
fnp-3806	4959	13	.	.	PUNCT
fnp-3806	4960	1	protective	protective	ADJ
fnp-3806	4960	2	effects	effect	NOUN
fnp-3806	4960	3	of	of	ADP
fnp-3806	4960	4	nsaids	nsaid	NOUN
fnp-3806	4960	5	on	on	ADP
fnp-3806	4960	6	the	the	DET
fnp-3806	4960	7	development	development	NOUN
fnp-3806	4960	8	of	of	ADP
fnp-3806	4960	9	alzheimer	alzheimer	PROPN
fnp-3806	4960	10	disease	disease	PROPN
fnp-3806	4960	11	.	.	PUNCT
fnp-3806	4961	1	neurology	neurology	NOUN
fnp-3806	4961	2	2008;70:1672	2008;70:1672	NUM
fnp-3806	4961	3	-	-	SYM
fnp-3806	4961	4	1677	1677	NUM
fnp-3806	4961	5	.	.	PUNCT
fnp-3806	4962	1	10.1212/01.wnl.0000311269.57716.63	10.1212/01.wnl.0000311269.57716.63	NUM
fnp-3806	4962	2	.	.	PUNCT
fnp-3806	4963	1	terzi	terzi	PROPN
fnp-3806	4963	2	m	m	PROPN
fnp-3806	4963	3	,	,	PUNCT
fnp-3806	4963	4	altun	altun	NOUN
fnp-3806	4963	5	g	g	PROPN
fnp-3806	4963	6	,	,	PUNCT
fnp-3806	4963	7	şen	şen	PROPN
fnp-3806	4963	8	s	s	PROPN
fnp-3806	4963	9	,	,	PUNCT
fnp-3806	4963	10	et	et	PROPN
fnp-3806	4963	11	al	al	PROPN
fnp-3806	4963	12	.	.	PUNCT
fnp-3806	4964	1	the	the	DET
fnp-3806	4964	2	use	use	NOUN
fnp-3806	4964	3	of	of	ADP
fnp-3806	4964	4	non	non	ADJ
fnp-3806	4964	5	-	-	ADJ
fnp-3806	4964	6	steroidal	steroidal	ADJ
fnp-3806	4964	7	anti	anti	ADJ
fnp-3806	4964	8	-	-	ADJ
fnp-3806	4964	9	inflammatory	inflammatory	ADJ
fnp-3806	4964	10	drugs	drug	NOUN
fnp-3806	4964	11	in	in	ADP
fnp-3806	4964	12	neurological	neurological	ADJ
fnp-3806	4964	13	diseases	disease	NOUN
fnp-3806	4964	14	.	.	PUNCT
fnp-3806	4965	1	j	j	PROPN
fnp-3806	4965	2	chem	chem	PROPN
fnp-3806	4965	3	neuroanat	neuroanat	PROPN
fnp-3806	4965	4	2018;87:12	2018;87:12	PROPN
fnp-3806	4965	5	-	-	SYM
fnp-3806	4965	6	24	24	NUM
fnp-3806	4965	7	.	.	PUNCT
fnp-3806	4966	1	https://doi.org/10.1016/j.jchemneu.2017.03.003	https://doi.org/10.1016/j.jchemneu.2017.03.003	VERB
fnp-3806	4966	2	kaduševičius	kaduševičius	PROPN
fnp-3806	4966	3	e.	e.	PROPN
fnp-3806	4966	4	novel	novel	PROPN
fnp-3806	4966	5	applications	application	NOUN
fnp-3806	4966	6	of	of	ADP
fnp-3806	4966	7	nsaids	nsaid	NOUN
fnp-3806	4966	8	:	:	PUNCT
fnp-3806	4966	9	insight	insight	NOUN
fnp-3806	4966	10	and	and	CCONJ
fnp-3806	4966	11	future	future	ADJ
fnp-3806	4966	12	perspectives	perspective	NOUN
fnp-3806	4966	13	in	in	ADP
fnp-3806	4966	14	cardiovascular	cardiovascular	ADJ
fnp-3806	4966	15	,	,	PUNCT
fnp-3806	4966	16	neurodegenerative	neurodegenerative	ADJ
fnp-3806	4966	17	,	,	PUNCT
fnp-3806	4966	18	diabetes	diabetes	NOUN
fnp-3806	4966	19	and	and	CCONJ
fnp-3806	4966	20	cancer	cancer	NOUN
fnp-3806	4966	21	disease	disease	NOUN
fnp-3806	4966	22	therapy	therapy	NOUN
fnp-3806	4966	23	.	.	PUNCT
fnp-3806	4967	1	int	int	PROPN
fnp-3806	4967	2	j	j	PROPN
fnp-3806	4967	3	mol	mol	ADP
fnp-3806	4967	4	sci	sci	PROPN
fnp-3806	4967	5	2021;22:6637	2021;22:6637	PROPN
fnp-3806	4967	6	.	.	PUNCT
fnp-3806	4968	1	https://doi.org/10.3390/ijms22126637	https://doi.org/10.3390/ijms22126637	PROPN
fnp-3806	4968	2	wilberding	wilberde	VERB
fnp-3806	4968	3	a	a	PRON
fnp-3806	4968	4	,	,	PUNCT
fnp-3806	4968	5	morimoto	morimoto	PROPN
fnp-3806	4968	6	k	k	PROPN
fnp-3806	4968	7	,	,	PUNCT
fnp-3806	4968	8	satoh	satoh	NOUN
fnp-3806	4968	9	h	h	NOUN
fnp-3806	4968	10	,	,	PUNCT
fnp-3806	4968	11	et	et	PROPN
fnp-3806	4968	12	al	al	PROPN
fnp-3806	4968	13	.	.	PUNCT
fnp-3806	4969	1	multiple	multiple	ADJ
fnp-3806	4969	2	cytokines	cytokine	NOUN
fnp-3806	4969	3	are	be	AUX
fnp-3806	4969	4	involved	involve	VERB
fnp-3806	4969	5	in	in	ADP
fnp-3806	4969	6	the	the	DET
fnp-3806	4969	7	early	early	ADJ
fnp-3806	4969	8	events	event	NOUN
fnp-3806	4969	9	leading	lead	VERB
fnp-3806	4969	10	to	to	ADP
fnp-3806	4969	11	the	the	DET
fnp-3806	4969	12	alzheimer	alzheimer	NOUN
fnp-3806	4969	13	's	's	PART
fnp-3806	4969	14	disease	disease	NOUN
fnp-3806	4969	15	pathology.tottori	pathology.tottori	PROPN
fnp-3806	4969	16	rinsho	rinsho	VERB
fnp-3806	4969	17	kagaku	kagaku	PROPN
fnp-3806	4969	18	kenkyukai	kenkyukai	PROPN
fnp-3806	4969	19	shi	shi	PROPN
fnp-3806	4969	20	2008;1:359	2008;1:359	PROPN
fnp-3806	4969	21	-	-	SYM
fnp-3806	4969	22	373	373	NUM
fnp-3806	4969	23	.	.	PUNCT
fnp-3806	4970	1	pmid	pmid	NOUN
fnp-3806	4970	2	:	:	PUNCT
fnp-3806	4970	3	22586434	22586434	NUM
fnp-3806	4970	4	.	.	PUNCT
fnp-3806	4971	1	sajdel	sajdel	NOUN
fnp-3806	4971	2	-	-	PUNCT
fnp-3806	4971	3	sulkowska	sulkowska	PROPN
fnp-3806	4971	4	em	em	PRON
fnp-3806	4971	5	,	,	PUNCT
fnp-3806	4971	6	marotta	marotta	ADJ
fnp-3806	4971	7	ca	ca	NOUN
fnp-3806	4971	8	.	.	PUNCT
fnp-3806	4972	1	alzheimer	alzheimer	PROPN
fnp-3806	4972	2	's	's	PART
fnp-3806	4972	3	disease	disease	NOUN
fnp-3806	4972	4	brain	brain	NOUN
fnp-3806	4972	5	:	:	PUNCT
fnp-3806	4972	6	alterations	alteration	NOUN
fnp-3806	4972	7	in	in	ADP
fnp-3806	4972	8	rna	rna	NOUN
fnp-3806	4972	9	levels	level	NOUN
fnp-3806	4972	10	and	and	CCONJ
fnp-3806	4972	11	in	in	ADP
fnp-3806	4972	12	a	a	DET
fnp-3806	4972	13	ribonuclease	ribonuclease	NOUN
fnp-3806	4972	14	-	-	PUNCT
fnp-3806	4972	15	inhibitor	inhibitor	NOUN
fnp-3806	4972	16	complex	complex	NOUN
fnp-3806	4972	17	.	.	PUNCT
fnp-3806	4973	1	science	science	NOUN
fnp-3806	4973	2	1984;225	1984;225	NUM
fnp-3806	4973	3	:	:	PUNCT
fnp-3806	4974	1	947	947	NUM
fnp-3806	4974	2	-	-	SYM
fnp-3806	4974	3	949	949	NUM
fnp-3806	4974	4	.	.	PUNCT
fnp-3806	4974	5	https://doi.org/10.1126/science.6206567	https://doi.org/10.1126/science.6206567	X
fnp-3806	4974	6	langstrom	langstrom	ADP
fnp-3806	4974	7	ns	ns	PROPN
fnp-3806	4974	8	,	,	PUNCT
fnp-3806	4974	9	anderson	anderson	PROPN
fnp-3806	4974	10	jp	jp	PROPN
fnp-3806	4974	11	,	,	PUNCT
fnp-3806	4974	12	lindroos	lindroos	PROPN
fnp-3806	4974	13	hg	hg	PROPN
fnp-3806	4974	14	,	,	PUNCT
fnp-3806	4974	15	et	et	PROPN
fnp-3806	4974	16	al	al	PROPN
fnp-3806	4974	17	.	.	PROPN
fnp-3806	4974	18	alzheimer	alzheimer	PROPN
fnp-3806	4974	19	's	's	PART
fnp-3806	4974	20	disease	disease	NOUN
fnp-3806	4974	21	-	-	PUNCT
fnp-3806	4974	22	associated	associate	VERB
fnp-3806	4974	23	reduction	reduction	NOUN
fnp-3806	4974	24	of	of	ADP
fnp-3806	4974	25	polysomal	polysomal	ADJ
fnp-3806	4974	26	mrna	mrna	PROPN
fnp-3806	4974	27	translation	translation	PROPN
fnp-3806	4974	28	.	.	PUNCT
fnp-3806	4975	1	brain	brain	NOUN
fnp-3806	4975	2	res	re	NOUN
fnp-3806	4975	3	mol	mol	ADP
fnp-3806	4975	4	brain	brain	NOUN
fnp-3806	4975	5	res	re	NOUN
fnp-3806	4975	6	1989;5:259	1989;5:259	NUM
fnp-3806	4975	7	-	-	SYM
fnp-3806	4975	8	269	269	NUM
fnp-3806	4975	9	.	.	PUNCT
fnp-3806	4976	1	https://doi.org/10.1016/0169-328x(89)90060-0	https://doi.org/10.1016/0169-328x(89)90060-0	PROPN
fnp-3806	4976	2	da	da	PROPN
fnp-3806	4976	3	silva	silva	PROPN
fnp-3806	4976	4	am	am	PROPN
fnp-3806	4976	5	,	,	PUNCT
fnp-3806	4976	6	payão	payão	PROPN
fnp-3806	4976	7	sl	sl	PROPN
fnp-3806	4976	8	,	,	PUNCT
fnp-3806	4976	9	borsatto	borsatto	NOUN
fnp-3806	4976	10	b	b	PROPN
fnp-3806	4976	11	,	,	PUNCT
fnp-3806	4976	12	et	et	PROPN
fnp-3806	4976	13	al	al	PROPN
fnp-3806	4976	14	.	.	PROPN
fnp-3806	4977	1	quantitative	quantitative	ADJ
fnp-3806	4977	2	evaluation	evaluation	NOUN
fnp-3806	4977	3	of	of	ADP
fnp-3806	4977	4	rrna	rrna	PROPN
fnp-3806	4977	5	in	in	ADP
fnp-3806	4977	6	alzheimer	alzheimer	PROPN
fnp-3806	4977	7	’s	’s	PART
fnp-3806	4977	8	disease	disease	NOUN
fnp-3806	4977	9	.	.	PUNCT
fnp-3806	4978	1	mech	mech	NOUN
fnp-3806	4978	2	ageing	age	VERB
fnp-3806	4978	3	dev	dev	PROPN
fnp-3806	4978	4	2000;120	2000;120	NUM
fnp-3806	4978	5	:	:	PUNCT
fnp-3806	4978	6	57	57	NUM
fnp-3806	4978	7	-	-	SYM
fnp-3806	4978	8	64	64	NUM
fnp-3806	4978	9	.	.	PUNCT
fnp-3806	4979	1	https://doi.org/10.1016/s0047-6374(00)00180-9	https://doi.org/10.1016/s0047-6374(00)00180-9	PROPN
fnp-3806	4979	2	ferrer	ferrer	PROPN
fnp-3806	4979	3	i.	i.	PROPN
fnp-3806	4979	4	differential	differential	PROPN
fnp-3806	4979	5	expression	expression	NOUN
fnp-3806	4979	6	of	of	ADP
fnp-3806	4979	7	phosphorylated	phosphorylate	VERB
fnp-3806	4979	8	translation	translation	NOUN
fnp-3806	4979	9	initiation	initiation	NOUN
fnp-3806	4979	10	factor	factor	NOUN
fnp-3806	4979	11	2	2	NUM
fnp-3806	4979	12	alpha	alpha	NOUN
fnp-3806	4979	13	in	in	ADP
fnp-3806	4979	14	alzheimer	alzheimer	PROPN
fnp-3806	4979	15	's	's	PART
fnp-3806	4979	16	disease	disease	NOUN
fnp-3806	4979	17	and	and	CCONJ
fnp-3806	4979	18	creutzfeldt	creutzfeldt	ADJ
fnp-3806	4979	19	-	-	PUNCT
fnp-3806	4979	20	jakob	jakob	PROPN
fnp-3806	4979	21	's	's	PART
fnp-3806	4979	22	disease	disease	NOUN
fnp-3806	4979	23	.	.	PUNCT
fnp-3806	4980	1	neuropathol	neuropathol	PROPN
fnp-3806	4980	2	appl	appl	PROPN
fnp-3806	4980	3	neurobiol	neurobiol	PROPN
fnp-3806	4980	4	2002;28	2002;28	NOUN
fnp-3806	4980	5	:	:	PUNCT
fnp-3806	4980	6	441	441	NUM
fnp-3806	4980	7	-	-	SYM
fnp-3806	4980	8	451	451	NUM
fnp-3806	4980	9	.	.	PUNCT
fnp-3806	4981	1	https://doi.org/10.1046/j.1365-2990.2002.t01-1-00410.x	https://doi.org/10.1046/j.1365-2990.2002.t01-1-00410.x	PROPN
fnp-3806	4981	2	shan	shan	PROPN
fnp-3806	4981	3	x	x	PROPN
fnp-3806	4981	4	,	,	PUNCT
fnp-3806	4981	5	tashiro	tashiro	PROPN
fnp-3806	4981	6	h	h	NOUN
fnp-3806	4981	7	,	,	PUNCT
fnp-3806	4981	8	lin	lin	PROPN
fnp-3806	4981	9	cl	cl	PROPN
fnp-3806	4981	10	.	.	PUNCT
fnp-3806	4982	1	the	the	DET
fnp-3806	4982	2	identification	identification	NOUN
fnp-3806	4982	3	and	and	CCONJ
fnp-3806	4982	4	characterization	characterization	NOUN
fnp-3806	4982	5	of	of	ADP
fnp-3806	4982	6	oxidized	oxidize	VERB
fnp-3806	4982	7	rnas	rna	NOUN
fnp-3806	4982	8	in	in	ADP
fnp-3806	4982	9	alzheimer	alzheimer	PROPN
fnp-3806	4982	10	's	's	PART
fnp-3806	4982	11	disease	disease	NOUN
fnp-3806	4982	12	.	.	PUNCT
fnp-3806	4983	1	j	j	PROPN
fnp-3806	4983	2	neurosci	neurosci	PROPN
fnp-3806	4983	3	2003;23	2003;23	NUM
fnp-3806	4983	4	:	:	PUNCT
fnp-3806	4983	5	4913	4913	NUM
fnp-3806	4983	6	-	-	SYM
fnp-3806	4983	7	4921	4921	NUM
fnp-3806	4983	8	.	.	PUNCT
fnp-3806	4984	1	https://doi.org/10.1523/jneurosci.23-12-04913.2003	https://doi.org/10.1523/jneurosci.23-12-04913.2003	PROPN
fnp-3806	4984	2	li	li	PROPN
fnp-3806	4984	3	x	x	PROPN
fnp-3806	4984	4	,	,	PUNCT
fnp-3806	4984	5	an	an	DET
fnp-3806	4984	6	wl	wl	PROPN
fnp-3806	4984	7	,	,	PUNCT
fnp-3806	4984	8	alafuzoff	alafuzoff	NOUN
fnp-3806	4985	1	i	i	PRON
fnp-3806	4985	2	,	,	PUNCT
fnp-3806	4985	3	et	et	PROPN
fnp-3806	4985	4	al	al	PROPN
fnp-3806	4985	5	.	.	PROPN
fnp-3806	4985	6	phosphorylated	phosphorylate	VERB
fnp-3806	4985	7	eukaryotic	eukaryotic	ADJ
fnp-3806	4985	8	translation	translation	NOUN
fnp-3806	4985	9	factor	factor	NOUN
fnp-3806	4985	10	4e	4e	NOUN
fnp-3806	4985	11	is	be	AUX
fnp-3806	4985	12	elevated	elevate	VERB
fnp-3806	4985	13	in	in	ADP
fnp-3806	4985	14	alzheimer	alzheimer	PROPN
fnp-3806	4985	15	brain	brain	NOUN
fnp-3806	4985	16	.	.	PUNCT
fnp-3806	4986	1	neuroreport	neuroreport	NOUN
fnp-3806	4986	2	2004;15	2004;15	NUM
fnp-3806	4986	3	:	:	PUNCT
fnp-3806	4986	4	2237	2237	NUM
fnp-3806	4986	5	-	-	SYM
fnp-3806	4986	6	2240	2240	NUM
fnp-3806	4986	7	.	.	PUNCT
fnp-3806	4987	1	https://doi.org/10.1097/00001756-200410050-00019	https://doi.org/10.1097/00001756-200410050-00019	X
fnp-3806	4987	2	nunomura	nunomura	NOUN
fnp-3806	4987	3	a	a	PRON
fnp-3806	4987	4	,	,	PUNCT
fnp-3806	4987	5	perry	perry	PROPN
fnp-3806	4987	6	g.	g.	PROPN
fnp-3806	4987	7	rna	rna	PROPN
fnp-3806	4987	8	and	and	CCONJ
fnp-3806	4987	9	oxidative	oxidative	ADJ
fnp-3806	4987	10	stress	stress	NOUN
fnp-3806	4987	11	in	in	ADP
fnp-3806	4987	12	alzheimer	alzheimer	PROPN
fnp-3806	4987	13	's	's	PART
fnp-3806	4987	14	disease	disease	NOUN
fnp-3806	4987	15	:	:	PUNCT
fnp-3806	4987	16	focus	focus	VERB
fnp-3806	4987	17	on	on	ADP
fnp-3806	4987	18	micrornas	microrna	NOUN
fnp-3806	4987	19	.	.	PUNCT
fnp-3806	4988	1	oxid	oxid	PROPN
fnp-3806	4988	2	med	med	ADJ
fnp-3806	4988	3	cell	cell	NOUN
fnp-3806	4988	4	longev	longev	NOUN
fnp-3806	4988	5	2020;2020:2638130	2020;2020:2638130	NUM
fnp-3806	4988	6	.	.	PUNCT
fnp-3806	4989	1	https://doi.org/10.1155/2020/2638130	https://doi.org/10.1155/2020/2638130	PROPN
fnp-3806	4989	2	dönmez	dönmez	NOUN
fnp-3806	4989	3	-	-	PUNCT
fnp-3806	4989	4	altuntas	altunta	NOUN
fnp-3806	4989	5	h	h	NOUN
fnp-3806	4989	6	,	,	PUNCT
fnp-3806	4989	7	akalain	akalain	ADJ
fnp-3806	4989	8	h	h	NOUN
fnp-3806	4989	9	,	,	PUNCT
fnp-3806	4989	10	karaman	karaman	PROPN
fnp-3806	4989	11	y	y	PROPN
fnp-3806	4989	12	,	,	PUNCT
fnp-3806	4989	13	et	et	PROPN
fnp-3806	4989	14	al	al	PROPN
fnp-3806	4989	15	.	.	PUNCT
fnp-3806	4989	16	evaluation	evaluation	NOUN
fnp-3806	4989	17	of	of	ADP
fnp-3806	4989	18	the	the	DET
fnp-3806	4989	19	nucleolar	nucleolar	ADJ
fnp-3806	4989	20	organizer	organizer	NOUN
fnp-3806	4989	21	regions	region	NOUN
fnp-3806	4989	22	in	in	ADP
fnp-3806	4989	23	alzheimer	alzheimer	PROPN
fnp-3806	4989	24	’s	’s	PART
fnp-3806	4989	25	disease	disease	NOUN
fnp-3806	4989	26	.	.	PUNCT
fnp-3806	4990	1	gerontology	gerontology	NOUN
fnp-3806	4990	2	2005;51	2005;51	NUM
fnp-3806	4990	3	:	:	PUNCT
fnp-3806	4990	4	297	297	NUM
fnp-3806	4990	5	-	-	SYM
fnp-3806	4990	6	301	301	NUM
fnp-3806	4990	7	.	.	PUNCT
fnp-3806	4991	1	https://doi.org/10.1159/000086365	https://doi.org/10.1159/000086365	PROPN
fnp-3806	4991	2	honda	honda	PROPN
fnp-3806	4992	1	k	k	PROPN
fnp-3806	4992	2	,	,	PUNCT
fnp-3806	4992	3	smith	smith	PROPN
fnp-3806	4992	4	ma	ma	PROPN
fnp-3806	4992	5	,	,	PUNCT
fnp-3806	4992	6	zhu	zhu	PROPN
fnp-3806	4992	7	x	x	X
fnp-3806	4992	8	,	,	PUNCT
fnp-3806	4992	9	et	et	PROPN
fnp-3806	4992	10	al	al	PROPN
fnp-3806	4992	11	.	.	PROPN
fnp-3806	4992	12	ribosomal	ribosomal	PROPN
fnp-3806	4992	13	rna	rna	PROPN
fnp-3806	4992	14	in	in	ADP
fnp-3806	4992	15	alzheimer	alzheimer	PROPN
fnp-3806	4992	16	disease	disease	NOUN
fnp-3806	4992	17	is	be	AUX
fnp-3806	4992	18	oxidized	oxidize	VERB
fnp-3806	4992	19	by	by	ADP
fnp-3806	4992	20	bound	bind	VERB
fnp-3806	4992	21	redox	redox	NOUN
fnp-3806	4992	22	-	-	PUNCT
fnp-3806	4992	23	active	active	ADJ
fnp-3806	4992	24	iron.j	iron.j	PUNCT
fnp-3806	4992	25	biol	biol	ADJ
fnp-3806	4992	26	chem	chem	NOUN
fnp-3806	4992	27	2005;280:20978	2005;280:20978	NUM
fnp-3806	4992	28	-	-	SYM
fnp-3806	4992	29	20986	20986	NUM
fnp-3806	4992	30	.	.	PUNCT
fnp-3806	4993	1	https://doi.org/10.1074/jbc.m500526200	https://doi.org/10.1074/jbc.m500526200	X
fnp-3806	4993	2	ding	ding	PROPN
fnp-3806	4993	3	q	q	NOUN
fnp-3806	4993	4	,	,	PUNCT
fnp-3806	4993	5	markesbery	markesbery	PROPN
fnp-3806	4993	6	wr	wr	PROPN
fnp-3806	4993	7	,	,	PUNCT
fnp-3806	4993	8	chen	chen	PROPN
fnp-3806	4993	9	q	q	PROPN
fnp-3806	4993	10	,	,	PUNCT
fnp-3806	4993	11	et	et	PROPN
fnp-3806	4993	12	al	al	PROPN
fnp-3806	4993	13	.	.	PROPN
fnp-3806	4993	14	ribosome	ribosome	PROPN
fnp-3806	4993	15	dysfunction	dysfunction	NOUN
fnp-3806	4993	16	is	be	AUX
fnp-3806	4993	17	an	an	DET
fnp-3806	4993	18	early	early	ADJ
fnp-3806	4993	19	event	event	NOUN
fnp-3806	4993	20	in	in	ADP
fnp-3806	4993	21	alzheimer	alzheimer	PROPN
fnp-3806	4993	22	’s	’s	PART
fnp-3806	4993	23	disease	disease	NOUN
fnp-3806	4993	24	.	.	PUNCT
fnp-3806	4994	1	j	j	PROPN
fnp-3806	4994	2	neurosci	neurosci	PROPN
fnp-3806	4994	3	2005;25	2005;25	NOUN
fnp-3806	4994	4	:	:	PUNCT
fnp-3806	4994	5	9171	9171	NUM
fnp-3806	4994	6	-	-	SYM
fnp-3806	4994	7	9175	9175	NUM
fnp-3806	4994	8	.	.	PUNCT
fnp-3806	4995	1	https://doi.org/10.1523/jneurosci.3040-05.2005	https://doi.org/10.1523/jneurosci.3040-05.2005	PROPN
fnp-3806	4995	2	ding	ding	PROPN
fnp-3806	4995	3	q	q	NOUN
fnp-3806	4995	4	,	,	PUNCT
fnp-3806	4995	5	markesbery	markesbery	PROPN
fnp-3806	4995	6	wr	wr	PROPN
fnp-3806	4995	7	,	,	PUNCT
fnp-3806	4995	8	cecarini	cecarini	PROPN
fnp-3806	4995	9	v	v	PROPN
fnp-3806	4995	10	,	,	PUNCT
fnp-3806	4995	11	et	et	PROPN
fnp-3806	4995	12	al	al	PROPN
fnp-3806	4995	13	.	.	PROPN
fnp-3806	4995	14	decreased	decrease	VERB
fnp-3806	4995	15	rna	rna	PROPN
fnp-3806	4995	16	,	,	PUNCT
fnp-3806	4995	17	and	and	CCONJ
fnp-3806	4995	18	increased	increase	VERB
fnp-3806	4995	19	rna	rna	NOUN
fnp-3806	4995	20	oxidation	oxidation	NOUN
fnp-3806	4995	21	,	,	PUNCT
fnp-3806	4995	22	in	in	ADP
fnp-3806	4995	23	ribosomes	ribosome	NOUN
fnp-3806	4995	24	from	from	ADP
fnp-3806	4995	25	early	early	PROPN
fnp-3806	4995	26	alzheimer	alzheimer	PROPN
fnp-3806	4995	27	’s	’s	PART
fnp-3806	4995	28	disease	disease	NOUN
fnp-3806	4995	29	.	.	PUNCT
fnp-3806	4996	1	neurochem	neurochem	PROPN
fnp-3806	4996	2	res	re	VERB
fnp-3806	4996	3	2006;31:705	2006;31:705	NOUN
fnp-3806	4996	4	-	-	SYM
fnp-3806	4996	5	710	710	NUM
fnp-3806	4996	6	.	.	PUNCT
fnp-3806	4997	1	https://doi.org/10.1007/s11064-006-9071-5	https://doi.org/10.1007/s11064-006-9071-5	PROPN
fnp-3806	4997	2	shan	shan	PROPN
fnp-3806	4997	3	x	x	PROPN
fnp-3806	4997	4	,	,	PUNCT
fnp-3806	4997	5	lin	lin	PROPN
fnp-3806	4997	6	cl	cl	NOUN
fnp-3806	4997	7	.	.	PUNCT
fnp-3806	4998	1	quantification	quantification	NOUN
fnp-3806	4998	2	of	of	ADP
fnp-3806	4998	3	oxidized	oxidize	VERB
fnp-3806	4998	4	rnas	rna	NOUN
fnp-3806	4998	5	in	in	ADP
fnp-3806	4998	6	alzheimer	alzheimer	PROPN
fnp-3806	4998	7	's	's	PART
fnp-3806	4998	8	disease	disease	NOUN
fnp-3806	4998	9	.	.	PUNCT
fnp-3806	4999	1	neurobiol	neurobiol	PROPN
fnp-3806	4999	2	aging	age	VERB
fnp-3806	4999	3	2006	2006	NUM
fnp-3806	4999	4	27	27	NUM
fnp-3806	4999	5	:	:	PUNCT
fnp-3806	4999	6	657	657	NUM
fnp-3806	4999	7	-	-	SYM
fnp-3806	4999	8	662	662	NUM
fnp-3806	4999	9	.	.	PUNCT
fnp-3806	5000	1	https://doi.org/10.1016/j.neurobiolaging.2005.03.022	https://doi.org/10.1016/j.neurobiolaging.2005.03.022	NOUN
fnp-3806	5000	2	eftekharzadeh	eftekharzadeh	NOUN
fnp-3806	5000	3	b	b	NOUN
fnp-3806	5000	4	,	,	PUNCT
fnp-3806	5000	5	daigle	daigle	VERB
fnp-3806	5000	6	jg	jg	PROPN
fnp-3806	5000	7	,	,	PUNCT
fnp-3806	5000	8	kapinos	kapinos	PROPN
fnp-3806	5000	9	le	le	X
fnp-3806	5000	10	,	,	PUNCT
fnp-3806	5000	11	et	et	PROPN
fnp-3806	5000	12	al	al	PROPN
fnp-3806	5000	13	.	.	PUNCT
fnp-3806	5001	1	tau	tau	PROPN
fnp-3806	5001	2	protein	protein	NOUN
fnp-3806	5001	3	disrupts	disrupt	VERB
fnp-3806	5001	4	nucleocytoplasmic	nucleocytoplasmic	ADJ
fnp-3806	5001	5	transport	transport	NOUN
fnp-3806	5001	6	in	in	ADP
fnp-3806	5001	7	alzheimer	alzheimer	PROPN
fnp-3806	5001	8	disease	disease	PROPN
fnp-3806	5001	9	.	.	PUNCT
fnp-3806	5002	1	neuron	neuron	PROPN
fnp-3806	5002	2	2018;99:925	2018;99:925	PROPN
fnp-3806	5002	3	-	-	PUNCT
fnp-3806	5002	4	940.e7	940.e7	NUM
fnp-3806	5002	5	.	.	PUNCT
fnp-3806	5003	1	https://doi.org/10.1016/j.neuron.2018.07.039	https://doi.org/10.1016/j.neuron.2018.07.039	NOUN
fnp-3806	5003	2	hernández	hernández	PROPN
fnp-3806	5003	3	-	-	PUNCT
fnp-3806	5003	4	ortega	ortega	PROPN
fnp-3806	5003	5	k	k	PROPN
fnp-3806	5003	6	,	,	PUNCT
fnp-3806	5003	7	garcia	garcia	PROPN
fnp-3806	5003	8	-	-	PUNCT
fnp-3806	5003	9	esparcia	esparcia	PROPN
fnp-3806	5003	10	p	p	NOUN
fnp-3806	5003	11	,	,	PUNCT
fnp-3806	5003	12	gil	gil	PROPN
fnp-3806	5003	13	l	l	PROPN
fnp-3806	5003	14	,	,	PUNCT
fnp-3806	5003	15	et	et	PROPN
fnp-3806	5003	16	al	al	PROPN
fnp-3806	5003	17	.	.	PROPN
fnp-3806	5003	18	altered	alter	VERB
fnp-3806	5003	19	machinery	machinery	NOUN
fnp-3806	5003	20	of	of	ADP
fnp-3806	5003	21	protein	protein	NOUN
fnp-3806	5003	22	synthesis	synthesis	NOUN
fnp-3806	5003	23	in	in	ADP
fnp-3806	5003	24	alzheimer	alzheimer	PROPN
fnp-3806	5003	25	’s	’s	PART
fnp-3806	5003	26	:	:	PUNCT
fnp-3806	5003	27	from	from	ADP
fnp-3806	5003	28	the	the	DET
fnp-3806	5003	29	nucleolus	nucleolus	NOUN
fnp-3806	5003	30	to	to	ADP
fnp-3806	5003	31	the	the	DET
fnp-3806	5003	32	ribosome	ribosome	NOUN
fnp-3806	5003	33	.	.	PUNCT
fnp-3806	5004	1	brain	brain	NOUN
fnp-3806	5004	2	pathol	pathol	NOUN
fnp-3806	5004	3	2016;26	2016;26	NUM
fnp-3806	5004	4	:	:	PUNCT
fnp-3806	5004	5	593	593	NUM
fnp-3806	5004	6	-	-	SYM
fnp-3806	5004	7	605	605	NUM
fnp-3806	5004	8	.	.	PUNCT
fnp-3806	5005	1	https://doi.org/10.1111/bpa.12335	https://doi.org/10.1111/bpa.12335	PROPN
fnp-3806	5005	2	di	di	NOUN
fnp-3806	5005	3	domenico	domenico	PROPN
fnp-3806	5005	4	f	f	PROPN
fnp-3806	5005	5	,	,	PUNCT
fnp-3806	5005	6	sultana	sultana	NOUN
fnp-3806	5005	7	r	r	PROPN
fnp-3806	5005	8	,	,	PUNCT
fnp-3806	5005	9	barone	barone	X
fnp-3806	5005	10	e	e	NOUN
fnp-3806	5005	11	,	,	PUNCT
fnp-3806	5005	12	et	et	PROPN
fnp-3806	5005	13	al	al	PROPN
fnp-3806	5005	14	.	.	PROPN
fnp-3806	5006	1	quantitative	quantitative	ADJ
fnp-3806	5006	2	proteomics	proteomic	NOUN
fnp-3806	5006	3	analysis	analysis	NOUN
fnp-3806	5006	4	of	of	ADP
fnp-3806	5006	5	phosphorylated	phosphorylate	VERB
fnp-3806	5006	6	proteins	protein	NOUN
fnp-3806	5006	7	in	in	ADP
fnp-3806	5006	8	the	the	DET
fnp-3806	5006	9	hippocampus	hippocampus	NOUN
fnp-3806	5006	10	of	of	ADP
fnp-3806	5006	11	alzheimer	alzheimer	PROPN
fnp-3806	5006	12	's	's	PART
fnp-3806	5006	13	disease	disease	NOUN
fnp-3806	5006	14	subjects	subject	NOUN
fnp-3806	5006	15	.	.	PUNCT
fnp-3806	5007	1	j	j	PROPN
fnp-3806	5007	2	proteomics	proteomic	NOUN
fnp-3806	5007	3	2011;74:1091	2011;74:1091	NUM
fnp-3806	5007	4	-	-	SYM
fnp-3806	5007	5	1103	1103	NUM
fnp-3806	5007	6	.	.	PUNCT
fnp-3806	5008	1	https://doi.org/10.1016/j.jprot.2011.03.033	https://doi.org/10.1016/j.jprot.2011.03.033	VERB
fnp-3806	5008	2	xia	xia	PROPN
fnp-3806	5009	1	q	q	PROPN
fnp-3806	5009	2	,	,	PUNCT
fnp-3806	5009	3	cheng	cheng	PROPN
fnp-3806	5009	4	d	d	PROPN
fnp-3806	5009	5	,	,	PUNCT
fnp-3806	5009	6	duong	duong	PROPN
fnp-3806	5010	1	dm	dm	PROPN
fnp-3806	5010	2	,	,	PUNCT
fnp-3806	5010	3	et	et	PROPN
fnp-3806	5010	4	al	al	PROPN
fnp-3806	5010	5	.	.	PUNCT
fnp-3806	5011	1	phosphoproteomic	phosphoproteomic	ADJ
fnp-3806	5011	2	analysis	analysis	NOUN
fnp-3806	5011	3	of	of	ADP
fnp-3806	5011	4	human	human	ADJ
fnp-3806	5011	5	brain	brain	NOUN
fnp-3806	5011	6	by	by	ADP
fnp-3806	5011	7	calcium	calcium	NOUN
fnp-3806	5011	8	phosphate	phosphate	NOUN
fnp-3806	5011	9	precipitation	precipitation	NOUN
fnp-3806	5011	10	and	and	CCONJ
fnp-3806	5011	11	mass	mass	ADJ
fnp-3806	5011	12	spectrometry	spectrometry	NOUN
fnp-3806	5011	13	.	.	PUNCT
fnp-3806	5012	1	j	j	PROPN
fnp-3806	5012	2	proteome	proteome	PROPN
fnp-3806	5012	3	res	re	NOUN
fnp-3806	5012	4	2008;7:2845	2008;7:2845	PROPN
fnp-3806	5012	5	-	-	SYM
fnp-3806	5012	6	2851	2851	NUM
fnp-3806	5012	7	.	.	PUNCT
fnp-3806	5013	1	https://doi.org/10.1021/pr8000496	https://doi.org/10.1021/pr8000496	PROPN
fnp-3806	5013	2	tan	tan	PROPN
fnp-3806	5013	3	h	h	PROPN
fnp-3806	5013	4	,	,	PUNCT
fnp-3806	5013	5	wu	wu	PROPN
fnp-3806	5013	6	z	z	PROPN
fnp-3806	5013	7	,	,	PUNCT
fnp-3806	5013	8	wang	wang	PROPN
fnp-3806	5013	9	h	h	PROPN
fnp-3806	5013	10	,	,	PUNCT
fnp-3806	5013	11	et	et	PROPN
fnp-3806	5013	12	al	al	PROPN
fnp-3806	5013	13	.	.	PROPN
fnp-3806	5013	14	refined	refine	VERB
fnp-3806	5013	15	phosphopeptide	phosphopeptide	NOUN
fnp-3806	5013	16	enrichment	enrichment	NOUN
fnp-3806	5013	17	by	by	ADP
fnp-3806	5013	18	phosphate	phosphate	ADJ
fnp-3806	5013	19	additive	additive	NOUN
fnp-3806	5013	20	and	and	CCONJ
fnp-3806	5013	21	the	the	DET
fnp-3806	5013	22	analysis	analysis	NOUN
fnp-3806	5013	23	of	of	ADP
fnp-3806	5013	24	human	human	ADJ
fnp-3806	5013	25	brain	brain	NOUN
fnp-3806	5013	26	phosphoproteome	phosphoproteome	NOUN
fnp-3806	5013	27	.	.	PUNCT
fnp-3806	5014	1	proteomics	proteomic	NOUN
fnp-3806	5014	2	2015;15:500	2015;15:500	NUM
fnp-3806	5014	3	-	-	SYM
fnp-3806	5014	4	507	507	NUM
fnp-3806	5014	5	.	.	PUNCT
fnp-3806	5014	6	https://doi.org/10.1002/pmic.201400171	https://doi.org/10.1002/pmic.201400171	VERB
fnp-3806	5014	7	triplett	triplett	PROPN
fnp-3806	5014	8	jc	jc	PROPN
fnp-3806	5014	9	,	,	PUNCT
fnp-3806	5014	10	swomley	swomley	PROPN
fnp-3806	5014	11	am	am	PROPN
fnp-3806	5014	12	,	,	PUNCT
fnp-3806	5014	13	cai	cai	PROPN
fnp-3806	5014	14	j	j	PROPN
fnp-3806	5014	15	,	,	PUNCT
fnp-3806	5014	16	et	et	PROPN
fnp-3806	5014	17	al	al	PROPN
fnp-3806	5014	18	.	.	PROPN
fnp-3806	5015	1	quantitative	quantitative	ADJ
fnp-3806	5015	2	phosphoproteomic	phosphoproteomic	ADJ
fnp-3806	5015	3	analyses	analysis	NOUN
fnp-3806	5015	4	of	of	ADP
fnp-3806	5015	5	the	the	DET
fnp-3806	5015	6	inferior	inferior	ADJ
fnp-3806	5015	7	parietal	parietal	ADJ
fnp-3806	5015	8	lobule	lobule	NOUN
fnp-3806	5015	9	from	from	ADP
fnp-3806	5015	10	three	three	NUM
fnp-3806	5015	11	different	different	ADJ
fnp-3806	5015	12	pathological	pathological	ADJ
fnp-3806	5015	13	stages	stage	NOUN
fnp-3806	5015	14	of	of	ADP
fnp-3806	5015	15	alzheimer	alzheimer	PROPN
fnp-3806	5015	16	's	's	PART
fnp-3806	5015	17	disease	disease	NOUN
fnp-3806	5015	18	.	.	PUNCT
fnp-3806	5016	1	j	j	PROPN
fnp-3806	5016	2	alzheimers	alzheimers	PROPN
fnp-3806	5016	3	dis	dis	VERB
fnp-3806	5016	4	2016;49:45	2016;49:45	NUM
fnp-3806	5016	5	-	-	SYM
fnp-3806	5016	6	62	62	NUM
fnp-3806	5016	7	.	.	PUNCT
fnp-3806	5017	1	https://doi.org/10.3233/jad-150417	https://doi.org/10.3233/jad-150417	NUM
fnp-3806	5017	2	dammer	dammer	PROPN
fnp-3806	5017	3	eb	eb	PROPN
fnp-3806	5017	4	,	,	PUNCT
fnp-3806	5017	5	lee	lee	PROPN
fnp-3806	5017	6	ak	ak	PROPN
fnp-3806	5017	7	,	,	PUNCT
fnp-3806	5017	8	duong	duong	PROPN
fnp-3806	5018	1	dm	dm	PROPN
fnp-3806	5018	2	,	,	PUNCT
fnp-3806	5018	3	et	et	PROPN
fnp-3806	5018	4	al	al	PROPN
fnp-3806	5018	5	.	.	PROPN
fnp-3806	5019	1	quantitative	quantitative	ADJ
fnp-3806	5019	2	phosphoproteomics	phosphoproteomic	NOUN
fnp-3806	5019	3	of	of	ADP
fnp-3806	5019	4	alzheimer	alzheimer	PROPN
fnp-3806	5019	5	's	's	PART
fnp-3806	5019	6	disease	disease	NOUN
fnp-3806	5019	7	reveals	reveal	VERB
fnp-3806	5019	8	cross	cross	ADJ
fnp-3806	5019	9	-	-	ADJ
fnp-3806	5019	10	talk	talk	NOUN
fnp-3806	5019	11	between	between	ADP
fnp-3806	5019	12	kinases	kinase	NOUN
fnp-3806	5019	13	and	and	CCONJ
fnp-3806	5019	14	small	small	ADJ
fnp-3806	5019	15	heat	heat	NOUN
fnp-3806	5019	16	shock	shock	NOUN
fnp-3806	5019	17	proteins	protein	NOUN
fnp-3806	5019	18	.	.	PUNCT
fnp-3806	5020	1	proteomics	proteomic	NOUN
fnp-3806	5020	2	2015;15:508	2015;15:508	NOUN
fnp-3806	5020	3	-	-	SYM
fnp-3806	5020	4	519	519	NUM
fnp-3806	5020	5	.	.	PUNCT
fnp-3806	5021	1	https://doi.org/10.1002/pmic.201400189	https://doi.org/10.1002/pmic.201400189	PROPN
fnp-3806	5021	2	sathe	sathe	PROPN
fnp-3806	5021	3	g	g	PROPN
fnp-3806	5021	4	,	,	PUNCT
fnp-3806	5021	5	mangalaparthi	mangalaparthi	PROPN
fnp-3806	5021	6	kk	kk	PROPN
fnp-3806	5021	7	,	,	PUNCT
fnp-3806	5021	8	jain	jain	PROPN
fnp-3806	5021	9	a	a	DET
fnp-3806	5021	10	,	,	PUNCT
fnp-3806	5021	11	et	et	PROPN
fnp-3806	5021	12	al	al	PROPN
fnp-3806	5021	13	.	.	PROPN
fnp-3806	5021	14	multiplexed	multiplexed	ADJ
fnp-3806	5021	15	phosphoproteomic	phosphoproteomic	ADJ
fnp-3806	5021	16	study	study	NOUN
fnp-3806	5021	17	of	of	ADP
fnp-3806	5021	18	the	the	DET
fnp-3806	5021	19	brain	brain	NOUN
fnp-3806	5021	20	in	in	ADP
fnp-3806	5021	21	patients	patient	NOUN
fnp-3806	5021	22	with	with	ADP
fnp-3806	5021	23	alzheimer	alzheimer	PROPN
fnp-3806	5021	24	's	's	PART
fnp-3806	5021	25	disease	disease	NOUN
fnp-3806	5021	26	and	and	CCONJ
fnp-3806	5021	27	age	age	NOUN
fnp-3806	5021	28	-	-	PUNCT
fnp-3806	5021	29	matched	match	VERB
fnp-3806	5021	30	cognitively	cognitively	ADV
fnp-3806	5021	31	healthy	healthy	ADJ
fnp-3806	5021	32	controls	control	NOUN
fnp-3806	5021	33	.	.	PUNCT
fnp-3806	5022	1	omics	omics	PROPN
fnp-3806	5022	2	2020;24:2016	2020;24:2016	PROPN
fnp-3806	5022	3	-	-	SYM
fnp-3806	5022	4	2227	2227	NUM
fnp-3806	5022	5	.	.	PUNCT
fnp-3806	5023	1	https://doi.org/10.1089/omi.2019.0191	https://doi.org/10.1089/omi.2019.0191	PROPN
fnp-3806	5023	2	bai	bai	PROPN
fnp-3806	5023	3	b	b	PROPN
fnp-3806	5023	4	,	,	PUNCT
fnp-3806	5023	5	wang	wang	PROPN
fnp-3806	5023	6	x	x	PROPN
fnp-3806	5023	7	,	,	PUNCT
fnp-3806	5023	8	li	li	PROPN
fnp-3806	5023	9	y	y	PROPN
fnp-3806	5023	10	,	,	PUNCT
fnp-3806	5023	11	et	et	PROPN
fnp-3806	5023	12	al	al	PROPN
fnp-3806	5023	13	.	.	PUNCT
fnp-3806	5024	1	deep	deep	ADJ
fnp-3806	5024	2	multilayer	multilayer	ADJ
fnp-3806	5024	3	brain	brain	NOUN
fnp-3806	5024	4	proteomics	proteomic	NOUN
fnp-3806	5024	5	identifies	identify	VERB
fnp-3806	5024	6	molecular	molecular	ADJ
fnp-3806	5024	7	networks	network	NOUN
fnp-3806	5024	8	in	in	ADP
fnp-3806	5024	9	alzheimer	alzheimer	PROPN
fnp-3806	5024	10	's	's	PART
fnp-3806	5024	11	disease	disease	NOUN
fnp-3806	5024	12	progression	progression	NOUN
fnp-3806	5024	13	.	.	PUNCT
fnp-3806	5025	1	neuron	neuron	PROPN
fnp-3806	5025	2	2020;105	2020;105	NUM
fnp-3806	5025	3	:	:	PUNCT
fnp-3806	5025	4	975	975	NUM
fnp-3806	5025	5	-	-	SYM
fnp-3806	5025	6	991.e7	991.e7	NUM
fnp-3806	5025	7	.	.	PUNCT
fnp-3806	5026	1	https://doi.org/10.1016/j.neuron.2019.12.015	https://doi.org/10.1016/j.neuron.2019.12.015	NOUN
fnp-3806	5026	2	mérida	mérida	PROPN
fnp-3806	5027	1	i	i	PROPN
fnp-3806	5027	2	,	,	PUNCT
fnp-3806	5027	3	avila	avila	PROPN
fnp-3806	5027	4	-	-	PUNCT
fnp-3806	5027	5	flores	flores	PROPN
fnp-3806	5027	6	a	a	PRON
fnp-3806	5027	7	,	,	PUNCT
fnp-3806	5027	8	merino	merino	PROPN
fnp-3806	5027	9	e.	e.	PROPN
fnp-3806	5027	10	diacylglycerol	diacylglycerol	PROPN
fnp-3806	5027	11	kinases	kinase	NOUN
fnp-3806	5027	12	:	:	PUNCT
fnp-3806	5027	13	at	at	ADP
fnp-3806	5027	14	the	the	DET
fnp-3806	5027	15	hub	hub	NOUN
fnp-3806	5027	16	of	of	ADP
fnp-3806	5027	17	cell	cell	NOUN
fnp-3806	5027	18	signalling	signal	VERB
fnp-3806	5027	19	.	.	PUNCT
fnp-3806	5028	1	biochem	biochem	PROPN
fnp-3806	5028	2	j	j	PROPN
fnp-3806	5028	3	2008;409:1	2008;409:1	NUM
fnp-3806	5028	4	-	-	SYM
fnp-3806	5028	5	18	18	NUM
fnp-3806	5028	6	.	.	PUNCT
fnp-3806	5029	1	https://doi.org/10.1042/bj20071040	https://doi.org/10.1042/bj20071040	PUNCT
fnp-3806	5029	2	almena	almena	PROPN
fnp-3806	5029	3	m	m	PROPN
fnp-3806	5029	4	,	,	PUNCT
fnp-3806	5029	5	mérida	mérida	PROPN
fnp-3806	5029	6	i.	i.	PROPN
fnp-3806	5029	7	shaping	shape	VERB
fnp-3806	5029	8	up	up	ADP
fnp-3806	5029	9	the	the	DET
fnp-3806	5029	10	membrane	membrane	NOUN
fnp-3806	5029	11	:	:	PUNCT
fnp-3806	5029	12	diacylglycerol	diacylglycerol	PROPN
fnp-3806	5029	13	coordinates	coordinate	NOUN
fnp-3806	5029	14	spatial	spatial	ADJ
fnp-3806	5029	15	orientation	orientation	NOUN
fnp-3806	5029	16	of	of	ADP
fnp-3806	5029	17	signalling	signal	VERB
fnp-3806	5029	18	.	.	PUNCT
fnp-3806	5030	1	trends	trend	NOUN
fnp-3806	5030	2	biochem	biochem	PROPN
fnp-3806	5030	3	sci	sci	PROPN
fnp-3806	5030	4	2011;36:593	2011;36:593	PROPN
fnp-3806	5030	5	-	-	SYM
fnp-3806	5030	6	603	603	NUM
fnp-3806	5030	7	.	.	PUNCT
fnp-3806	5031	1	https://doi.org/10.1016/j.tibs.2011.06.005	https://doi.org/10.1016/j.tibs.2011.06.005	VERB
fnp-3806	5031	2	sakane	sakane	NOUN
fnp-3806	5031	3	f	f	X
fnp-3806	5031	4	,	,	PUNCT
fnp-3806	5031	5	hoshino	hoshino	PROPN
fnp-3806	5031	6	f	f	PROPN
fnp-3806	5031	7	,	,	PUNCT
fnp-3806	5031	8	murakami	murakami	PROPN
fnp-3806	5031	9	c.	c.	PROPN
fnp-3806	5031	10	new	new	ADJ
fnp-3806	5031	11	era	era	NOUN
fnp-3806	5031	12	of	of	ADP
fnp-3806	5031	13	diacylglycerol	diacylglycerol	PROPN
fnp-3806	5031	14	kinase	kinase	PROPN
fnp-3806	5031	15	,	,	PUNCT
fnp-3806	5031	16	phosphatidic	phosphatidic	ADJ
fnp-3806	5031	17	acid	acid	NOUN
fnp-3806	5031	18	and	and	CCONJ
fnp-3806	5031	19	phosphatidic	phosphatidic	ADJ
fnp-3806	5031	20	acid	acid	NOUN
fnp-3806	5031	21	-	-	PUNCT
fnp-3806	5031	22	binding	bind	VERB
fnp-3806	5031	23	protein	protein	NOUN
fnp-3806	5031	24	.	.	PUNCT
fnp-3806	5032	1	int	int	PROPN
fnp-3806	5032	2	j	j	PROPN
fnp-3806	5032	3	mol	mol	ADP
fnp-3806	5032	4	sci	sci	PROPN
fnp-3806	5032	5	2020;21:6794	2020;21:6794	PROPN
fnp-3806	5032	6	.	.	PUNCT
fnp-3806	5033	1	https://doi.org/10.3390/ijms21186794	https://doi.org/10.3390/ijms21186794	NOUN
fnp-3806	5033	2	ekinci	ekinci	PROPN
fnp-3806	5033	3	fj	fj	PROPN
fnp-3806	5033	4	,	,	PUNCT
fnp-3806	5033	5	shea	shea	PROPN
fnp-3806	5033	6	tb	tb	PROPN
fnp-3806	5033	7	.	.	PUNCT
fnp-3806	5034	1	free	free	PROPN
fnp-3806	5034	2	pkc	pkc	PROPN
fnp-3806	5034	3	catalytic	catalytic	ADJ
fnp-3806	5034	4	subunits	subunit	NOUN
fnp-3806	5034	5	(	(	PUNCT
fnp-3806	5034	6	pkm	pkm	NOUN
fnp-3806	5034	7	)	)	PUNCT
fnp-3806	5034	8	phosphorylate	phosphorylate	VERB
fnp-3806	5034	9	tau	tau	PROPN
fnp-3806	5034	10	via	via	ADP
fnp-3806	5034	11	a	a	DET
fnp-3806	5034	12	pathway	pathway	NOUN
fnp-3806	5034	13	distinct	distinct	ADJ
fnp-3806	5034	14	from	from	ADP
fnp-3806	5034	15	that	that	PRON
fnp-3806	5034	16	utilized	utilize	VERB
fnp-3806	5034	17	by	by	ADP
fnp-3806	5034	18	intact	intact	ADJ
fnp-3806	5034	19	pkc	pkc	NOUN
fnp-3806	5034	20	.	.	PUNCT
fnp-3806	5035	1	brain	brain	NOUN
fnp-3806	5035	2	res	re	NOUN
fnp-3806	5035	3	1999;850:207	1999;850:207	PROPN
fnp-3806	5035	4	-	-	SYM
fnp-3806	5035	5	216	216	NUM
fnp-3806	5035	6	.	.	PUNCT
fnp-3806	5036	1	https://doi.org/10.1016/s0006-8993(99)02146-0	https://doi.org/10.1016/s0006-8993(99)02146-0	PROPN
fnp-3806	5036	2	chan	chan	PROPN
fnp-3806	5036	3	rb	rb	PROPN
fnp-3806	5036	4	,	,	PUNCT
fnp-3806	5036	5	oliveira	oliveira	PROPN
fnp-3806	5036	6	tg	tg	PROPN
fnp-3806	5036	7	,	,	PUNCT
fnp-3806	5036	8	cortes	corte	VERB
fnp-3806	5036	9	ep	ep	PROPN
fnp-3806	5036	10	,	,	PUNCT
fnp-3806	5037	1	et	et	PROPN
fnp-3806	5037	2	al	al	PROPN
fnp-3806	5037	3	.	.	PROPN
fnp-3806	5037	4	comparative	comparative	ADJ
fnp-3806	5037	5	lipidomic	lipidomic	ADJ
fnp-3806	5037	6	analysis	analysis	NOUN
fnp-3806	5037	7	of	of	ADP
fnp-3806	5037	8	mouse	mouse	NOUN
fnp-3806	5037	9	and	and	CCONJ
fnp-3806	5037	10	human	human	ADJ
fnp-3806	5037	11	brain	brain	NOUN
fnp-3806	5037	12	with	with	ADP
fnp-3806	5037	13	alzheimer	alzheimer	PROPN
fnp-3806	5037	14	disease	disease	PROPN
fnp-3806	5037	15	.	.	PUNCT
fnp-3806	5038	1	j	j	PROPN
fnp-3806	5038	2	biol	biol	PROPN
fnp-3806	5038	3	chem	chem	NOUN
fnp-3806	5038	4	2012;287:2678	2012;287:2678	NUM
fnp-3806	5038	5	-	-	SYM
fnp-3806	5038	6	2688	2688	NUM
fnp-3806	5038	7	.	.	PUNCT
fnp-3806	5039	1	https://doi.org/10.1074/jbc.m111.274142	https://doi.org/10.1074/jbc.m111.274142	PRON
fnp-3806	5039	2	wood	wood	PROPN
fnp-3806	5039	3	pl	pl	PROPN
fnp-3806	5039	4	,	,	PUNCT
fnp-3806	5039	5	medicherla	medicherla	PROPN
fnp-3806	5039	6	s	s	X
fnp-3806	5039	7	,	,	PUNCT
fnp-3806	5039	8	sheikh	sheikh	PROPN
fnp-3806	5039	9	n	n	CCONJ
fnp-3806	5039	10	,	,	PUNCT
fnp-3806	5039	11	et	et	PROPN
fnp-3806	5039	12	al	al	PROPN
fnp-3806	5039	13	.	.	PROPN
fnp-3806	5039	14	targeted	target	VERB
fnp-3806	5039	15	lipidomics	lipidomic	NOUN
fnp-3806	5039	16	of	of	ADP
fnp-3806	5039	17	frontal	frontal	ADJ
fnp-3806	5039	18	cortex	cortex	NOUN
fnp-3806	5039	19	and	and	CCONJ
fnp-3806	5039	20	plasma	plasma	NOUN
fnp-3806	5039	21	diacylglycerols	diacylglycerol	NOUN
fnp-3806	5039	22	(	(	PUNCT
fnp-3806	5039	23	dag	dag	PROPN
fnp-3806	5039	24	)	)	PUNCT
fnp-3806	5039	25	in	in	ADP
fnp-3806	5039	26	mild	mild	ADJ
fnp-3806	5039	27	cognitive	cognitive	ADJ
fnp-3806	5039	28	impairment	impairment	NOUN
fnp-3806	5039	29	and	and	CCONJ
fnp-3806	5039	30	alzheimer	alzheimer	NOUN
fnp-3806	5039	31	's	's	PART
fnp-3806	5039	32	disease	disease	NOUN
fnp-3806	5039	33	:	:	PUNCT
fnp-3806	5039	34	validation	validation	NOUN
fnp-3806	5039	35	of	of	ADP
fnp-3806	5039	36	dag	dag	PROPN
fnp-3806	5039	37	accumulation	accumulation	NOUN
fnp-3806	5039	38	early	early	ADV
fnp-3806	5039	39	in	in	ADP
fnp-3806	5039	40	the	the	DET
fnp-3806	5039	41	pathophysiology	pathophysiology	NOUN
fnp-3806	5039	42	of	of	ADP
fnp-3806	5039	43	alzheimer	alzheimer	PROPN
fnp-3806	5039	44	's	's	PART
fnp-3806	5039	45	disease	disease	NOUN
fnp-3806	5039	46	.	.	PUNCT
fnp-3806	5040	1	j	j	PROPN
fnp-3806	5040	2	alzheimers	alzheimers	PROPN
fnp-3806	5040	3	dis	dis	PROPN
fnp-3806	5040	4	2015;48:537	2015;48:537	PROPN
fnp-3806	5040	5	-	-	SYM
fnp-3806	5040	6	546	546	NUM
fnp-3806	5040	7	.	.	PUNCT
fnp-3806	5041	1	https://doi.org/10.3233/jad-150336	https://doi.org/10.3233/jad-150336	PROPN
fnp-3806	5041	2	pinheiro	pinheiro	PROPN
fnp-3806	5041	3	l	l	PROPN
fnp-3806	5041	4	,	,	PUNCT
fnp-3806	5041	5	faustino	faustino	PROPN
fnp-3806	5041	6	c.	c.	PROPN
fnp-3806	5041	7	therapeutic	therapeutic	ADJ
fnp-3806	5041	8	strategies	strategy	NOUN
fnp-3806	5041	9	targeting	target	VERB
fnp-3806	5041	10	amyloid	amyloid	NOUN
fnp-3806	5041	11	-	-	PUNCT
fnp-3806	5041	12	β	β	PROPN
fnp-3806	5041	13	in	in	ADP
fnp-3806	5041	14	alzheimer	alzheimer	PROPN
fnp-3806	5041	15	's	's	PART
fnp-3806	5041	16	disease	disease	NOUN
fnp-3806	5041	17	.	.	PUNCT
fnp-3806	5042	1	curr	curr	PROPN
fnp-3806	5042	2	alzheimer	alzheimer	PROPN
fnp-3806	5042	3	res	res	PROPN
fnp-3806	5042	4	2019;16:418	2019;16:418	PROPN
fnp-3806	5042	5	-	-	SYM
fnp-3806	5042	6	452	452	NUM
fnp-3806	5042	7	.	.	PUNCT
fnp-3806	5043	1	https://doi.org/10.2174/1567205016666190321163438	https://doi.org/10.2174/1567205016666190321163438	PRON
fnp-3806	5043	2	icoll	icoll	PROPN
fnp-3806	5043	3	ja	ja	PROPN
fnp-3806	5043	4	,	,	PUNCT
fnp-3806	5043	5	wilkinson	wilkinson	PROPN
fnp-3806	5043	6	d	d	PROPN
fnp-3806	5043	7	,	,	PUNCT
fnp-3806	5043	8	holmes	holmes	PROPN
fnp-3806	5043	9	c	c	PROPN
fnp-3806	5043	10	,	,	PUNCT
fnp-3806	5043	11	et	et	PROPN
fnp-3806	5043	12	al	al	PROPN
fnp-3806	5043	13	.	.	PROPN
fnp-3806	5043	14	neuropathology	neuropathology	PROPN
fnp-3806	5043	15	of	of	ADP
fnp-3806	5043	16	human	human	PROPN
fnp-3806	5043	17	alzheimer	alzheimer	PROPN
fnp-3806	5043	18	disease	disease	NOUN
fnp-3806	5043	19	after	after	ADP
fnp-3806	5043	20	immunization	immunization	NOUN
fnp-3806	5043	21	with	with	ADP
fnp-3806	5043	22	amyloid	amyloid	NOUN
fnp-3806	5043	23	-	-	PUNCT
fnp-3806	5043	24	beta	beta	NOUN
fnp-3806	5043	25	peptide	peptide	NOUN
fnp-3806	5043	26	:	:	PUNCT
fnp-3806	5043	27	a	a	DET
fnp-3806	5043	28	case	case	NOUN
fnp-3806	5043	29	report	report	NOUN
fnp-3806	5043	30	.	.	PUNCT
fnp-3806	5044	1	nat	nat	PROPN
fnp-3806	5044	2	med	med	PROPN
fnp-3806	5044	3	2003;9	2003;9	NUM
fnp-3806	5044	4	:	:	PUNCT
fnp-3806	5044	5	448	448	NUM
fnp-3806	5044	6	-	-	SYM
fnp-3806	5044	7	452	452	NUM
fnp-3806	5044	8	.	.	PUNCT
fnp-3806	5045	1	https://doi.org/10.1038/nm840	https://doi.org/10.1038/nm840	PROPN
fnp-3806	5045	2	nicoll	nicoll	PROPN
fnp-3806	5045	3	jar	jar	PROPN
fnp-3806	5045	4	,	,	PUNCT
fnp-3806	5045	5	buckland	buckland	PROPN
fnp-3806	5045	6	gr	gr	PROPN
fnp-3806	5045	7	,	,	PUNCT
fnp-3806	5045	8	harrison	harrison	PROPN
fnp-3806	5045	9	ch	ch	PROPN
fnp-3806	5045	10	,	,	PUNCT
fnp-3806	5045	11	et	et	PROPN
fnp-3806	5045	12	al	al	PROPN
fnp-3806	5045	13	.	.	PUNCT
fnp-3806	5046	1	persistent	persistent	ADJ
fnp-3806	5046	2	neuropathological	neuropathological	ADJ
fnp-3806	5046	3	effects	effect	NOUN
fnp-3806	5046	4	14	14	NUM
fnp-3806	5046	5	years	year	NOUN
fnp-3806	5046	6	following	follow	VERB
fnp-3806	5046	7	amyloid	amyloid	NOUN
fnp-3806	5046	8	-	-	PUNCT
fnp-3806	5046	9	β	β	NOUN
fnp-3806	5046	10	immunization	immunization	NOUN
fnp-3806	5046	11	in	in	ADP
fnp-3806	5046	12	alzheimer	alzheimer	PROPN
fnp-3806	5046	13	's	's	PART
fnp-3806	5046	14	disease	disease	NOUN
fnp-3806	5046	15	.	.	PUNCT
fnp-3806	5047	1	brain	brain	NOUN
fnp-3806	5047	2	2019	2019	NUM
fnp-3806	5047	3	;	;	PUNCT
fnp-3806	5047	4	142	142	NUM
fnp-3806	5047	5	:	:	PUNCT
fnp-3806	5047	6	2113	2113	NUM
fnp-3806	5047	7	-	-	SYM
fnp-3806	5047	8	2126	2126	NUM
fnp-3806	5047	9	.	.	PUNCT
fnp-3806	5048	1	https://doi.org/10.1093/brain/awz142	https://doi.org/10.1093/brain/awz142	PROPN
fnp-3806	5048	2	loureiro	loureiro	PROPN
fnp-3806	5048	3	jc	jc	PROPN
fnp-3806	5048	4	,	,	PUNCT
fnp-3806	5048	5	pais	pais	PROPN
fnp-3806	5048	6	mv	mv	PROPN
fnp-3806	5048	7	,	,	PUNCT
fnp-3806	5048	8	stella	stella	PROPN
fnp-3806	5048	9	f	f	PROPN
fnp-3806	5048	10	,	,	PUNCT
fnp-3806	5048	11	et	et	PROPN
fnp-3806	5048	12	al	al	PROPN
fnp-3806	5048	13	.	.	PROPN
fnp-3806	5049	1	passive	passive	ADJ
fnp-3806	5049	2	antiamyloid	antiamyloid	NOUN
fnp-3806	5049	3	immunotherapy	immunotherapy	NOUN
fnp-3806	5049	4	for	for	ADP
fnp-3806	5049	5	alzheimer	alzheimer	PROPN
fnp-3806	5049	6	’s	’s	PART
fnp-3806	5049	7	disease	disease	NOUN
fnp-3806	5049	8	.	.	PUNCT
fnp-3806	5050	1	curr	curr	PROPN
fnp-3806	5050	2	opin	opin	NOUN
fnp-3806	5050	3	psychiatry	psychiatry	NOUN
fnp-3806	5050	4	2020	2020	NUM
fnp-3806	5050	5	;	;	PUNCT
fnp-3806	5050	6	33	33	NUM
fnp-3806	5050	7	:	:	SYM
fnp-3806	5050	8	284	284	NUM
fnp-3806	5050	9	-	-	SYM
fnp-3806	5050	10	291	291	NUM
fnp-3806	5050	11	.	.	PUNCT
fnp-3806	5051	1	https://doi.org/10.1097/yco.0000000000000587	https://doi.org/10.1097/yco.0000000000000587	PROPN
fnp-3806	5051	2	honig	honig	PROPN
fnp-3806	5051	3	ls	ls	PROPN
fnp-3806	5051	4	,	,	PUNCT
fnp-3806	5051	5	vellas	vellas	PROPN
fnp-3806	5051	6	b	b	NUM
fnp-3806	5051	7	,	,	PUNCT
fnp-3806	5051	8	woodward	woodward	PROPN
fnp-3806	5051	9	m	m	PROPN
fnp-3806	5051	10	,	,	PUNCT
fnp-3806	5051	11	et	et	PROPN
fnp-3806	5051	12	al	al	PROPN
fnp-3806	5051	13	.	.	PUNCT
fnp-3806	5051	14	trial	trial	NOUN
fnp-3806	5051	15	of	of	ADP
fnp-3806	5051	16	solanezumab	solanezumab	NOUN
fnp-3806	5051	17	for	for	ADP
fnp-3806	5051	18	mild	mild	ADJ
fnp-3806	5051	19	dementia	dementia	NOUN
fnp-3806	5051	20	due	due	ADP
fnp-3806	5051	21	to	to	ADP
fnp-3806	5051	22	alzheimer	alzheimer	PROPN
fnp-3806	5051	23	’s	’s	PART
fnp-3806	5051	24	disease	disease	NOUN
fnp-3806	5051	25	.	.	PUNCT
fnp-3806	5052	1	n	n	PROPN
fnp-3806	5052	2	engl	engl	PROPN
fnp-3806	5052	3	j	j	PROPN
fnp-3806	5052	4	med	med	PROPN
fnp-3806	5052	5	2018	2018	NUM
fnp-3806	5052	6	;	;	PUNCT
fnp-3806	5052	7	378	378	NUM
fnp-3806	5052	8	,	,	PUNCT
fnp-3806	5052	9	321	321	NUM
fnp-3806	5052	10	-	-	SYM
fnp-3806	5052	11	330	330	NUM
fnp-3806	5052	12	.	.	PUNCT
fnp-3806	5053	1	https://doi.org/10.1056/nejmoa1705971	https://doi.org/10.1056/nejmoa1705971	PROPN
fnp-3806	5053	2	van	van	PROPN
fnp-3806	5053	3	bokhoven	bokhoven	NOUN
fnp-3806	5053	4	p	p	X
fnp-3806	5053	5	,	,	PUNCT
fnp-3806	5053	6	de	de	X
fnp-3806	5053	7	wilde	wilde	PROPN
fnp-3806	5053	8	a	a	PRON
fnp-3806	5053	9	,	,	PUNCT
fnp-3806	5053	10	vermunt	vermunt	NOUN
fnp-3806	5053	11	l	l	NOUN
fnp-3806	5053	12	,	,	PUNCT
fnp-3806	5053	13	et	et	PROPN
fnp-3806	5053	14	al	al	PROPN
fnp-3806	5053	15	.	.	PUNCT
fnp-3806	5054	1	the	the	DET
fnp-3806	5054	2	alzheimer	alzheimer	PROPN
fnp-3806	5054	3	’s	’s	PART
fnp-3806	5054	4	disease	disease	PROPN
fnp-3806	5054	5	drug	drug	NOUN
fnp-3806	5054	6	development	development	NOUN
fnp-3806	5054	7	landscape	landscape	NOUN
fnp-3806	5054	8	.	.	PUNCT
fnp-3806	5055	1	alzheimers	alzheimer	NOUN
fnp-3806	5055	2	res	re	VERB
fnp-3806	5055	3	ther	ther	ADV
fnp-3806	5055	4	2021;13:186	2021;13:186	PROPN
fnp-3806	5055	5	.	.	PUNCT
fnp-3806	5056	1	https://doi.org/10.1186/s13195-021-00927-z	https://doi.org/10.1186/s13195-021-00927-z	PROPN
fnp-3806	5056	2	abushouk	abushouk	PROPN
fnp-3806	5056	3	ai	ai	PROPN
fnp-3806	5056	4	,	,	PUNCT
fnp-3806	5056	5	elmaraezy	elmaraezy	VERB
fnp-3806	5057	1	a	a	DET
fnp-3806	5057	2	,	,	PUNCT
fnp-3806	5057	3	aglan	aglan	ADJ
fnp-3806	5057	4	a	a	PRON
fnp-3806	5057	5	,	,	PUNCT
fnp-3806	5057	6	et	et	PROPN
fnp-3806	5057	7	al	al	PROPN
fnp-3806	5057	8	.	.	PROPN
fnp-3806	5057	9	bapineuzumab	bapineuzumab	PROPN
fnp-3806	5057	10	for	for	ADP
fnp-3806	5057	11	mild	mild	ADJ
fnp-3806	5057	12	to	to	ADP
fnp-3806	5057	13	moderate	moderate	ADJ
fnp-3806	5057	14	alzheimer	alzheimer	PROPN
fnp-3806	5057	15	’s	’s	PART
fnp-3806	5057	16	disease	disease	NOUN
fnp-3806	5057	17	:	:	PUNCT
fnp-3806	5057	18	a	a	DET
fnp-3806	5057	19	meta	meta	ADJ
fnp-3806	5057	20	-	-	PUNCT
fnp-3806	5057	21	analysis	analysis	NOUN
fnp-3806	5057	22	of	of	ADP
fnp-3806	5057	23	randomized	randomized	ADJ
fnp-3806	5057	24	controlled	control	VERB
fnp-3806	5057	25	trials	trial	NOUN
fnp-3806	5057	26	.	.	PUNCT
fnp-3806	5058	1	bmc	bmc	PROPN
fnp-3806	5058	2	neurol	neurol	NOUN
fnp-3806	5058	3	2017;17:66	2017;17:66	NUM
fnp-3806	5058	4	.	.	PUNCT
fnp-3806	5059	1	https://doi.org/10.1186/s12883-017-0850-1	https://doi.org/10.1186/s12883-017-0850-1	PROPN
fnp-3806	5059	2	ratti	ratti	PROPN
fnp-3806	5059	3	e	e	PROPN
fnp-3806	5059	4	,	,	PUNCT
fnp-3806	5059	5	kong	kong	PROPN
fnp-3806	5059	6	j	j	PROPN
fnp-3806	5059	7	,	,	PUNCT
fnp-3806	5059	8	o’gorman	o’gorman	PROPN
fnp-3806	5059	9	j	j	PROPN
fnp-3806	5059	10	,	,	PUNCT
fnp-3806	5059	11	rajagovindan	rajagovindan	PROPN
fnp-3806	5059	12	r	r	PROPN
fnp-3806	5059	13	,	,	PUNCT
fnp-3806	5059	14	et	et	PROPN
fnp-3806	5059	15	al	al	PROPN
fnp-3806	5059	16	.	.	PROPN
fnp-3806	5059	17	baseline	baseline	PROPN
fnp-3806	5059	18	characteristics	characteristic	NOUN
fnp-3806	5059	19	from	from	ADP
fnp-3806	5059	20	tango	tango	NOUN
fnp-3806	5059	21	:	:	PUNCT
fnp-3806	5059	22	phase	phase	NOUN
fnp-3806	5059	23	2	2	NUM
fnp-3806	5059	24	study	study	NOUN
fnp-3806	5059	25	to	to	PART
fnp-3806	5059	26	evaluate	evaluate	VERB
fnp-3806	5059	27	gosuranemab	gosuranemab	NOUN
fnp-3806	5059	28	(	(	PUNCT
fnp-3806	5059	29	biib092	biib092	PROPN
fnp-3806	5059	30	)	)	PUNCT
fnp-3806	5059	31	in	in	ADP
fnp-3806	5059	32	patients	patient	NOUN
fnp-3806	5059	33	with	with	ADP
fnp-3806	5059	34	early	early	ADJ
fnp-3806	5059	35	alzheimer	alzheimer	PROPN
fnp-3806	5059	36	’s	’s	PART
fnp-3806	5059	37	disease	disease	NOUN
fnp-3806	5059	38	.	.	PUNCT
fnp-3806	5060	1	alzheimers	alzheimers	PROPN
fnp-3806	5060	2	dement	dement	PROPN
fnp-3806	5060	3	2020;16	2020;16	PROPN
fnp-3806	5060	4	,	,	PUNCT
fnp-3806	5060	5	e044910	e044910	PROPN
fnp-3806	5060	6	.	.	PUNCT
fnp-3806	5061	1	walsh	walsh	PROPN
fnp-3806	5061	2	s	s	PROPN
fnp-3806	5061	3	,	,	PUNCT
fnp-3806	5061	4	merrick	merrick	PROPN
fnp-3806	5061	5	r	r	PROPN
fnp-3806	5061	6	,	,	PUNCT
fnp-3806	5061	7	milne	milne	PROPN
fnp-3806	5061	8	r	r	PROPN
fnp-3806	5061	9	,	,	PUNCT
fnp-3806	5061	10	et	et	PROPN
fnp-3806	5061	11	al	al	PROPN
fnp-3806	5061	12	.	.	PROPN
fnp-3806	5061	13	aducanumab	aducanumab	PROPN
fnp-3806	5061	14	for	for	ADP
fnp-3806	5061	15	alzheimer	alzheimer	PROPN
fnp-3806	5061	16	’s	’s	PART
fnp-3806	5061	17	disease	disease	NOUN
fnp-3806	5061	18	?	?	PUNCT
fnp-3806	5062	1	bmj	bmj	PROPN
fnp-3806	5062	2	2021;374	2021;374	NUM
fnp-3806	5062	3	:	:	PUNCT
fnp-3806	5062	4	n1682	n1682	ADV
fnp-3806	5062	5	.	.	PUNCT
fnp-3806	5063	1	https://doi.org/10.1136/bmj.n1682	https://doi.org/10.1136/bmj.n1682	ADP
fnp-3806	5063	2	querol	querol	NOUN
fnp-3806	5063	3	-	-	PUNCT
fnp-3806	5063	4	vilaseca	vilaseca	NOUN
fnp-3806	5063	5	m	m	NOUN
fnp-3806	5063	6	,	,	PUNCT
fnp-3806	5063	7	sirisi	sirisi	ADJ
fnp-3806	5063	8	ms	ms	PROPN
fnp-3806	5063	9	,	,	PUNCT
fnp-3806	5063	10	molina	molina	PROPN
fnp-3806	5063	11	-	-	PUNCT
fnp-3806	5063	12	porcel	porcel	PROPN
fnp-3806	5063	13	l	l	PROPN
fnp-3806	5063	14	,	,	PUNCT
fnp-3806	5063	15	et	et	PROPN
fnp-3806	5063	16	al	al	PROPN
fnp-3806	5063	17	.	.	PROPN
fnp-3806	5063	18	neuropathology	neuropathology	NOUN
fnp-3806	5063	19	of	of	ADP
fnp-3806	5063	20	a	a	DET
fnp-3806	5063	21	patient	patient	NOUN
fnp-3806	5063	22	with	with	ADP
fnp-3806	5063	23	alzheimer	alzheimer	PROPN
fnp-3806	5063	24	disease	disease	NOUN
fnp-3806	5063	25	treated	treat	VERB
fnp-3806	5063	26	with	with	ADP
fnp-3806	5063	27	low	low	ADJ
fnp-3806	5063	28	doses	dose	NOUN
fnp-3806	5063	29	of	of	ADP
fnp-3806	5063	30	verubecestat	verubecestat	NOUN
fnp-3806	5063	31	.	.	PUNCT
fnp-3806	5064	1	neuropathol	neuropathol	NOUN
fnp-3806	5064	2	appl	appl	PROPN
fnp-3806	5064	3	neurobiol	neurobiol	PROPN
fnp-3806	5064	4	2022;48	2022;48	NUM
fnp-3806	5064	5	:	:	PUNCT
fnp-3806	5064	6	e12781	e12781	NOUN
fnp-3806	5064	7	.	.	PUNCT
fnp-3806	5065	1	https://doi.org/10.1111/nan.12781	https://doi.org/10.1111/nan.12781	INTJ
fnp-3806	5065	2	han	han	PROPN
fnp-3806	5065	3	p	p	PROPN
fnp-3806	5065	4	,	,	PUNCT
fnp-3806	5065	5	shi	shi	PROPN
fnp-3806	5065	6	j.a	j.a	PROPN
fnp-3806	5065	7	.	.	PROPN
fnp-3806	5065	8	theoretical	theoretical	ADJ
fnp-3806	5065	9	analysis	analysis	NOUN
fnp-3806	5065	10	of	of	ADP
fnp-3806	5065	11	the	the	DET
fnp-3806	5065	12	synergy	synergy	NOUN
fnp-3806	5065	13	of	of	ADP
fnp-3806	5065	14	amyloid	amyloid	NOUN
fnp-3806	5065	15	and	and	CCONJ
fnp-3806	5065	16	tau	tau	PROPN
fnp-3806	5065	17	in	in	ADP
fnp-3806	5065	18	alzheimer	alzheimer	PROPN
fnp-3806	5065	19	's	's	PART
fnp-3806	5065	20	disease	disease	NOUN
fnp-3806	5065	21	.	.	PUNCT
fnp-3806	5066	1	j	j	PROPN
fnp-3806	5066	2	alzheimers	alzheimers	PROPN
fnp-3806	5066	3	dis	dis	PROPN
fnp-3806	5067	1	2016;52:1461	2016;52:1461	NUM
fnp-3806	5067	2	-	-	SYM
fnp-3806	5067	3	70	70	NUM
fnp-3806	5067	4	.	.	PUNCT
fnp-3806	5068	1	https://doi.org/10.3233/jad-151206	https://doi.org/10.3233/jad-151206	PROPN
fnp-3806	5068	2	sherman	sherman	PROPN
fnp-3806	5068	3	ma	ma	PROPN
fnp-3806	5068	4	,	,	PUNCT
fnp-3806	5068	5	lacroix	lacroix	PROPN
fnp-3806	5068	6	m	m	PROPN
fnp-3806	5068	7	,	,	PUNCT
fnp-3806	5068	8	amar	amar	PROPN
fnp-3806	5068	9	f	f	PROPN
fnp-3806	5068	10	,	,	PUNCT
fnp-3806	5068	11	et	et	PROPN
fnp-3806	5068	12	al	al	PROPN
fnp-3806	5068	13	.	.	PROPN
fnp-3806	5069	1	soluble	soluble	ADJ
fnp-3806	5069	2	conformers	conformer	NOUN
fnp-3806	5069	3	of	of	ADP
fnp-3806	5069	4	aβ	aβ	PRON
fnp-3806	5069	5	and	and	CCONJ
fnp-3806	5069	6	tau	tau	PROPN
fnp-3806	5069	7	alter	alter	VERB
fnp-3806	5069	8	selective	selective	ADJ
fnp-3806	5069	9	proteins	protein	NOUN
fnp-3806	5069	10	governing	govern	VERB
fnp-3806	5069	11	axonal	axonal	ADJ
fnp-3806	5069	12	transport	transport	NOUN
fnp-3806	5069	13	.	.	PUNCT
fnp-3806	5070	1	j	j	PROPN
fnp-3806	5070	2	neurosci	neurosci	PROPN
fnp-3806	5070	3	2016;36:9647	2016;36:9647	PROPN
fnp-3806	5070	4	-	-	SYM
fnp-3806	5070	5	9658	9658	NUM
fnp-3806	5070	6	.	.	PUNCT
fnp-3806	5071	1	https://doi.org/10.1523/jneurosci.1899-16.2016	https://doi.org/10.1523/jneurosci.1899-16.2016	PROPN
fnp-3806	5071	2	kim	kim	PROPN
fnp-3806	5071	3	cm	cm	PROPN
fnp-3806	5071	4	,	,	PUNCT
fnp-3806	5071	5	montal	montal	ADJ
fnp-3806	5071	6	v	v	NOUN
fnp-3806	5071	7	,	,	PUNCT
fnp-3806	5071	8	diez	diez	PROPN
fnp-3806	5071	9	i	i	PROPN
fnp-3806	5071	10	,	,	PUNCT
fnp-3806	5071	11	et	et	PROPN
fnp-3806	5071	12	al	al	PROPN
fnp-3806	5071	13	.	.	PUNCT
fnp-3806	5072	1	network	network	NOUN
fnp-3806	5072	2	interdigitations	interdigitation	NOUN
fnp-3806	5072	3	of	of	ADP
fnp-3806	5072	4	tau	tau	PROPN
fnp-3806	5072	5	and	and	CCONJ
fnp-3806	5072	6	amyloid	amyloid	NOUN
fnp-3806	5072	7	-	-	PUNCT
fnp-3806	5072	8	beta	beta	NOUN
fnp-3806	5072	9	deposits	deposit	NOUN
fnp-3806	5072	10	define	define	VERB
fnp-3806	5072	11	cognitive	cognitive	ADJ
fnp-3806	5072	12	levels	level	NOUN
fnp-3806	5072	13	in	in	ADP
fnp-3806	5072	14	aging	age	VERB
fnp-3806	5072	15	.	.	PUNCT
fnp-3806	5073	1	hum	hum	PROPN
fnp-3806	5073	2	brain	brain	PROPN
fnp-3806	5073	3	mapp	mapp	PROPN
fnp-3806	5073	4	2021;42:2990	2021;42:2990	NUM
fnp-3806	5073	5	-	-	PROPN
fnp-3806	5073	6	3004	3004	NUM
fnp-3806	5073	7	.	.	PUNCT
fnp-3806	5074	1	https://doi.org/10.1002/hbm.25350	https://doi.org/10.1002/hbm.25350	PROPN
fnp-3806	5074	2	braczynski	braczynski	PROPN
fnp-3806	5074	3	ak	ak	PROPN
fnp-3806	5074	4	,	,	PUNCT
fnp-3806	5074	5	schulz	schulz	PROPN
fnp-3806	5074	6	jb	jb	PROPN
fnp-3806	5074	7	,	,	PUNCT
fnp-3806	5074	8	bach	bach	PROPN
fnp-3806	5074	9	jp	jp	PROPN
fnp-3806	5074	10	.	.	PUNCT
fnp-3806	5075	1	vaccination	vaccination	NOUN
fnp-3806	5075	2	strategies	strategy	NOUN
fnp-3806	5075	3	in	in	ADP
fnp-3806	5075	4	tauopathies	tauopathie	NOUN
fnp-3806	5075	5	and	and	CCONJ
fnp-3806	5075	6	synucleinopathies	synucleinopathie	NOUN
fnp-3806	5075	7	.	.	PUNCT
fnp-3806	5076	1	j	j	PROPN
fnp-3806	5076	2	neurochem	neurochem	PROPN
fnp-3806	5076	3	2017;143:467	2017;143:467	NUM
fnp-3806	5076	4	-	-	SYM
fnp-3806	5076	5	488	488	NUM
fnp-3806	5076	6	.	.	PUNCT
fnp-3806	5077	1	https://doi.org/10.1111/jnc.14207	https://doi.org/10.1111/jnc.14207	PROPN
fnp-3806	5077	2	congdon	congdon	PROPN
fnp-3806	5077	3	ee	ee	PROPN
fnp-3806	5077	4	,	,	PUNCT
fnp-3806	5077	5	sigurdson	sigurdson	PROPN
fnp-3806	5077	6	em	em	PRON
fnp-3806	5077	7	.	.	PUNCT
fnp-3806	5078	1	tau	tau	NOUN
fnp-3806	5078	2	-	-	PUNCT
fnp-3806	5078	3	targeting	target	VERB
fnp-3806	5078	4	therapies	therapy	NOUN
fnp-3806	5078	5	for	for	ADP
fnp-3806	5078	6	alzheimer	alzheimer	PROPN
fnp-3806	5078	7	’s	’s	PART
fnp-3806	5078	8	disease	disease	NOUN
fnp-3806	5078	9	.	.	PUNCT
fnp-3806	5079	1	nature	nature	PROPN
fnp-3806	5079	2	rev	rev	VERB
fnp-3806	5079	3	2018;14	2018;14	NUM
fnp-3806	5079	4	:	:	PUNCT
fnp-3806	5079	5	399	399	NUM
fnp-3806	5079	6	-	-	SYM
fnp-3806	5079	7	415	415	NUM
fnp-3806	5079	8	.	.	PUNCT
fnp-3806	5080	1	https://doi.org/10.1038/s41582-018-0013-z	https://doi.org/10.1038/s41582-018-0013-z	PROPN
fnp-3806	5080	2	medina	medina	PROPN
fnp-3806	5080	3	m.	m.	PROPN
fnp-3806	5080	4	an	an	DET
fnp-3806	5080	5	overview	overview	NOUN
fnp-3806	5080	6	on	on	ADP
fnp-3806	5080	7	the	the	DET
fnp-3806	5080	8	clinical	clinical	ADJ
fnp-3806	5080	9	development	development	NOUN
fnp-3806	5080	10	of	of	ADP
fnp-3806	5080	11	tau	tau	PROPN
fnp-3806	5080	12	-	-	PUNCT
fnp-3806	5080	13	based	base	VERB
fnp-3806	5080	14	therapies	therapy	NOUN
fnp-3806	5080	15	.	.	PUNCT
fnp-3806	5081	1	int	int	PROPN
fnp-3806	5081	2	j	j	PROPN
fnp-3806	5081	3	mol	mol	ADP
fnp-3806	5081	4	sci	sci	PROPN
fnp-3806	5081	5	2018;19:1160	2018;19:1160	PROPN
fnp-3806	5081	6	.	.	PUNCT
fnp-3806	5082	1	https://doi.org/10.3390/ijms19041160	https://doi.org/10.3390/ijms19041160	PROPN
fnp-3806	5082	2	jadhav	jadhav	PROPN
fnp-3806	5082	3	s	s	PROPN
fnp-3806	5082	4	,	,	PUNCT
fnp-3806	5082	5	avila	avila	PROPN
fnp-3806	5082	6	j	j	PROPN
fnp-3806	5082	7	,	,	PUNCT
fnp-3806	5082	8	schöll	schöll	PROPN
fnp-3806	5082	9	m	m	PROPN
fnp-3806	5082	10	,	,	PUNCT
fnp-3806	5082	11	et	et	PROPN
fnp-3806	5082	12	al	al	PROPN
fnp-3806	5082	13	.	.	PUNCT
fnp-3806	5083	1	a	a	DET
fnp-3806	5083	2	walk	walk	NOUN
fnp-3806	5083	3	through	through	ADP
fnp-3806	5083	4	tau	tau	PROPN
fnp-3806	5083	5	therapeutic	therapeutic	ADJ
fnp-3806	5083	6	strategies	strategy	NOUN
fnp-3806	5083	7	.	.	PUNCT
fnp-3806	5084	1	acta	acta	PROPN
fnp-3806	5084	2	neuropathol	neuropathol	PROPN
fnp-3806	5084	3	commun	commun	PROPN
fnp-3806	5084	4	2019;7:22	2019;7:22	NOUN
fnp-3806	5084	5	.	.	PUNCT
fnp-3806	5085	1	https://doi.org/10.1186/s40478-019-0664-z	https://doi.org/10.1186/s40478-019-0664-z	PROPN
fnp-3806	5085	2	mullard	mullard	PROPN
fnp-3806	5085	3	a.	a.	NOUN
fnp-3806	5085	4	failure	failure	NOUN
fnp-3806	5085	5	of	of	ADP
fnp-3806	5085	6	first	first	ADJ
fnp-3806	5085	7	anti	anti	ADJ
fnp-3806	5085	8	-	-	ADJ
fnp-3806	5085	9	tau	tau	ADJ
fnp-3806	5085	10	antibody	antibody	NOUN
fnp-3806	5085	11	in	in	ADP
fnp-3806	5085	12	alzheimer	alzheimer	PROPN
fnp-3806	5085	13	disease	disease	NOUN
fnp-3806	5085	14	highlights	highlight	VERB
fnp-3806	5085	15	risks	risk	NOUN
fnp-3806	5085	16	of	of	ADP
fnp-3806	5085	17	history	history	NOUN
fnp-3806	5085	18	repeating	repeat	VERB
fnp-3806	5085	19	.	.	PUNCT
fnp-3806	5086	1	nat	nat	PROPN
fnp-3806	5086	2	rev	rev	VERB
fnp-3806	5086	3	drug	drug	PROPN
fnp-3806	5086	4	discov	discov	PROPN
fnp-3806	5086	5	2020;20:3	2020;20:3	NOUN
fnp-3806	5086	6	-	-	SYM
fnp-3806	5086	7	5	5	NUM
fnp-3806	5086	8	.	.	PUNCT
fnp-3806	5086	9	https://doi.org/10.1038/d41573-020-00217-7	https://doi.org/10.1038/d41573-020-00217-7	VERB
fnp-3806	5087	1	loera	loera	NOUN
fnp-3806	5087	2	-	-	PUNCT
fnp-3806	5087	3	valencia	valencia	PROPN
fnp-3806	5087	4	r	r	NOUN
fnp-3806	5087	5	,	,	PUNCT
fnp-3806	5087	6	piras	piras	PRON
fnp-3806	5087	7	a	a	PRON
fnp-3806	5087	8	,	,	PUNCT
fnp-3806	5087	9	ismail	ismail	PROPN
fnp-3806	5087	10	mam	mam	PROPN
fnp-3806	5087	11	,	,	PUNCT
fnp-3806	5087	12	et	et	NOUN
fnp-3806	5087	13	al.targeting	al.targete	VERB
fnp-3806	5087	14	alzheimer	alzheimer	PROPN
fnp-3806	5087	15	’s	’s	PART
fnp-3806	5087	16	disease	disease	NOUN
fnp-3806	5087	17	with	with	ADP
fnp-3806	5087	18	gene	gene	NOUN
fnp-3806	5087	19	and	and	CCONJ
fnp-3806	5087	20	cell	cell	NOUN
fnp-3806	5087	21	therapies	therapy	NOUN
fnp-3806	5087	22	.	.	PUNCT
fnp-3806	5088	1	j	j	PROPN
fnp-3806	5088	2	intern	intern	NOUN
fnp-3806	5088	3	med	me	VERB
fnp-3806	5088	4	2018	2018	NUM
fnp-3806	5088	5	;	;	PUNCT
fnp-3806	5088	6	284:2	284:2	NUM
fnp-3806	5088	7	-	-	SYM
fnp-3806	5088	8	36	36	NUM
fnp-3806	5088	9	.	.	PUNCT
fnp-3806	5089	1	https://doi.org/10.1111/joim.12759	https://doi.org/10.1111/joim.12759	PROPN
fnp-3806	5089	2	dunbar	dunbar	PROPN
fnp-3806	5089	3	ce	ce	PROPN
fnp-3806	5089	4	,	,	PUNCT
fnp-3806	5089	5	high	high	PROPN
fnp-3806	5089	6	ka	ka	PROPN
fnp-3806	5089	7	,	,	PUNCT
fnp-3806	5089	8	joung	joung	PROPN
fnp-3806	5089	9	jk	jk	PROPN
fnp-3806	5089	10	,	,	PUNCT
fnp-3806	5089	11	et	et	PROPN
fnp-3806	5089	12	al	al	PROPN
fnp-3806	5089	13	.	.	PROPN
fnp-3806	5089	14	gene	gene	NOUN
fnp-3806	5089	15	therapy	therapy	NOUN
fnp-3806	5089	16	comes	come	VERB
fnp-3806	5089	17	of	of	ADP
fnp-3806	5089	18	age	age	NOUN
fnp-3806	5089	19	.	.	PUNCT
fnp-3806	5090	1	science	science	NOUN
fnp-3806	5090	2	2018	2018	NUM
fnp-3806	5090	3	;	;	PUNCT
fnp-3806	5090	4	359	359	NUM
fnp-3806	5090	5	:	:	PUNCT
fnp-3806	5090	6	eaan4672	eaan4672	PROPN
fnp-3806	5090	7	.	.	PUNCT
fnp-3806	5091	1	https://doi.org/10.1126/science.aan4672	https://doi.org/10.1126/science.aan4672	PROPN
fnp-3806	5091	2	lennon	lennon	PROPN
fnp-3806	5091	3	mj	mj	PROPN
fnp-3806	5091	4	,	,	PUNCT
fnp-3806	5091	5	rigney	rigney	PROPN
fnp-3806	5091	6	g	g	PROPN
fnp-3806	5091	7	,	,	PUNCT
fnp-3806	5091	8	raymont	raymont	ADJ
fnp-3806	5091	9	v	v	NOUN
fnp-3806	5091	10	,	,	PUNCT
fnp-3806	5091	11	et	et	PROPN
fnp-3806	5091	12	al	al	PROPN
fnp-3806	5091	13	.	.	PUNCT
fnp-3806	5092	1	genetic	genetic	ADJ
fnp-3806	5092	2	therapies	therapy	NOUN
fnp-3806	5092	3	for	for	ADP
fnp-3806	5092	4	alzheimer	alzheimer	PROPN
fnp-3806	5092	5	’s	’s	PART
fnp-3806	5092	6	disease	disease	NOUN
fnp-3806	5092	7	:	:	PUNCT
fnp-3806	5092	8	a	a	DET
fnp-3806	5092	9	scoping	scope	VERB
fnp-3806	5092	10	review	review	NOUN
fnp-3806	5092	11	.	.	PUNCT
fnp-3806	5093	1	j	j	PROPN
fnp-3806	5093	2	alz	alz	PROPN
fnp-3806	5093	3	dis	dis	PROPN
fnp-3806	5093	4	2021	2021	NUM
fnp-3806	5093	5	;	;	PUNCT
fnp-3806	5093	6	84	84	NUM
fnp-3806	5093	7	:	:	PUNCT
fnp-3806	5093	8	491	491	NUM
fnp-3806	5093	9	-	-	SYM
fnp-3806	5093	10	504	504	NUM
fnp-3806	5093	11	.	.	PUNCT
fnp-3806	5094	1	https://doi.org/10.3233/jad-215145	https://doi.org/10.3233/jad-215145	NUM
fnp-3806	5094	2	tuszynski	tuszynski	PROPN
fnp-3806	5094	3	mh	mh	PROPN
fnp-3806	5094	4	,	,	PUNCT
fnp-3806	5094	5	thal	thal	PROPN
fnp-3806	5094	6	l	l	PROPN
fnp-3806	5094	7	,	,	PUNCT
fnp-3806	5094	8	pay	pay	VERB
fnp-3806	5094	9	m	m	PROPN
fnp-3806	5094	10	,	,	PUNCT
fnp-3806	5094	11	et	et	PROPN
fnp-3806	5094	12	al	al	PROPN
fnp-3806	5094	13	.	.	PUNCT
fnp-3806	5095	1	a	a	DET
fnp-3806	5095	2	phase	phase	NOUN
fnp-3806	5095	3	1	1	NUM
fnp-3806	5095	4	clinical	clinical	ADJ
fnp-3806	5095	5	trial	trial	NOUN
fnp-3806	5095	6	of	of	ADP
fnp-3806	5095	7	nerve	nerve	NOUN
fnp-3806	5095	8	growth	growth	NOUN
fnp-3806	5095	9	factor	factor	NOUN
fnp-3806	5095	10	gene	gene	NOUN
fnp-3806	5095	11	therapy	therapy	NOUN
fnp-3806	5095	12	for	for	ADP
fnp-3806	5095	13	alzheimer	alzheimer	PROPN
fnp-3806	5095	14	disease	disease	NOUN
fnp-3806	5095	15	.	.	PUNCT
fnp-3806	5096	1	nat	nat	PROPN
fnp-3806	5096	2	med	med	PROPN
fnp-3806	5096	3	2005	2005	NUM
fnp-3806	5096	4	;	;	PUNCT
fnp-3806	5096	5	11	11	NUM
fnp-3806	5096	6	:	:	SYM
fnp-3806	5096	7	551	551	NUM
fnp-3806	5096	8	-	-	SYM
fnp-3806	5096	9	555	555	NUM
fnp-3806	5096	10	.	.	PUNCT
fnp-3806	5097	1	https://doi.org/10.1038/nm1239	https://doi.org/10.1038/nm1239	X
fnp-3806	5097	2	eriksdotter	eriksdotter	NOUN
fnp-3806	5097	3	-	-	PUNCT
fnp-3806	5097	4	jönhagen	jönhagen	PROPN
fnp-3806	5097	5	m	m	PROPN
fnp-3806	5097	6	,	,	PUNCT
fnp-3806	5097	7	linderoth	linderoth	PROPN
fnp-3806	5097	8	b	b	PROPN
fnp-3806	5097	9	,	,	PUNCT
fnp-3806	5097	10	lind	lind	PROPN
fnp-3806	5097	11	g	g	PROPN
fnp-3806	5097	12	,	,	PUNCT
fnp-3806	5097	13	et	et	PROPN
fnp-3806	5097	14	al	al	PROPN
fnp-3806	5097	15	.	.	PROPN
fnp-3806	5097	16	encapsulated	encapsulate	VERB
fnp-3806	5097	17	cell	cell	NOUN
fnp-3806	5097	18	biodelivery	biodelivery	NOUN
fnp-3806	5097	19	of	of	ADP
fnp-3806	5097	20	nerve	nerve	NOUN
fnp-3806	5097	21	growth	growth	NOUN
fnp-3806	5097	22	factor	factor	NOUN
fnp-3806	5097	23	to	to	ADP
fnp-3806	5097	24	the	the	DET
fnp-3806	5097	25	basal	basal	ADJ
fnp-3806	5097	26	forebrain	forebrain	NOUN
fnp-3806	5097	27	in	in	ADP
fnp-3806	5097	28	patients	patient	NOUN
fnp-3806	5097	29	with	with	ADP
fnp-3806	5097	30	alzheimer	alzheimer	PROPN
fnp-3806	5097	31	’s	’s	PART
fnp-3806	5097	32	disease	disease	NOUN
fnp-3806	5097	33	.	.	PUNCT
fnp-3806	5098	1	dement	dement	PROPN
fnp-3806	5098	2	geriatr	geriatr	PROPN
fnp-3806	5098	3	cogn	cogn	VERB
fnp-3806	5098	4	disord	disord	NOUN
fnp-3806	5098	5	2012;33:18	2012;33:18	NUM
fnp-3806	5098	6	-	-	PUNCT
fnp-3806	5098	7	28	28	NUM
fnp-3806	5098	8	.	.	PUNCT
fnp-3806	5099	1	https://doi.org/10.1159/000336051	https://doi.org/10.1159/000336051	PROPN
fnp-3806	5099	2	rafii	rafii	PROPN
fnp-3806	5099	3	ms	ms	PROPN
fnp-3806	5099	4	,	,	PUNCT
fnp-3806	5099	5	tuszynski	tuszynski	PROPN
fnp-3806	5099	6	mh	mh	PROPN
fnp-3806	5099	7	,	,	PUNCT
fnp-3806	5099	8	thomas	thomas	PROPN
fnp-3806	5099	9	rg	rg	PROPN
fnp-3806	5099	10	,	,	PUNCT
fnp-3806	5099	11	et	et	PROPN
fnp-3806	5099	12	al	al	PROPN
fnp-3806	5099	13	.	.	PROPN
fnp-3806	5099	14	adeno	adeno	PROPN
fnp-3806	5099	15	-	-	PUNCT
fnp-3806	5099	16	associated	associate	VERB
fnp-3806	5099	17	viral	viral	ADJ
fnp-3806	5099	18	vector	vector	NOUN
fnp-3806	5099	19	(	(	PUNCT
fnp-3806	5099	20	serotype	serotype	ADJ
fnp-3806	5099	21	2)-nerve	2)-nerve	NUM
fnp-3806	5099	22	growth	growth	NOUN
fnp-3806	5099	23	factor	factor	NOUN
fnp-3806	5099	24	for	for	ADP
fnp-3806	5099	25	patients	patient	NOUN
fnp-3806	5099	26	with	with	ADP
fnp-3806	5099	27	alzheimer	alzheimer	PROPN
fnp-3806	5099	28	disease	disease	PROPN
fnp-3806	5099	29	:	:	PUNCT
fnp-3806	5099	30	a	a	DET
fnp-3806	5099	31	randomized	randomized	ADJ
fnp-3806	5099	32	clinical	clinical	ADJ
fnp-3806	5099	33	trial	trial	NOUN
fnp-3806	5099	34	.	.	PUNCT
fnp-3806	5100	1	jama	jama	PROPN
fnp-3806	5100	2	neurol	neurol	PROPN
fnp-3806	5100	3	2018	2018	NUM
fnp-3806	5100	4	;	;	PUNCT
fnp-3806	5100	5	75	75	NUM
fnp-3806	5100	6	:	:	PUNCT
fnp-3806	5100	7	834	834	NUM
fnp-3806	5100	8	-	-	SYM
fnp-3806	5100	9	841	841	NUM
fnp-3806	5100	10	.	.	PUNCT
fnp-3806	5101	1	https://doi.org/10.1001/jamaneurol.2018.0233	https://doi.org/10.1001/jamaneurol.2018.0233	PROPN
fnp-3806	5101	2	huang	huang	PROPN
fnp-3806	5101	3	lk	lk	PROPN
fnp-3806	5101	4	,	,	PUNCT
fnp-3806	5101	5	chao	chao	PROPN
fnp-3806	5101	6	sp	sp	PROPN
fnp-3806	5101	7	,	,	PUNCT
fnp-3806	5101	8	hu	hu	PROPN
fnp-3806	5101	9	cj	cj	PROPN
fnp-3806	5101	10	.	.	PUNCT
fnp-3806	5102	1	clinical	clinical	ADJ
fnp-3806	5102	2	trials	trial	NOUN
fnp-3806	5102	3	of	of	ADP
fnp-3806	5102	4	new	new	ADJ
fnp-3806	5102	5	drugs	drug	NOUN
fnp-3806	5102	6	for	for	ADP
fnp-3806	5102	7	alzheimer	alzheimer	PROPN
fnp-3806	5102	8	disease	disease	NOUN
fnp-3806	5102	9	.	.	PUNCT
fnp-3806	5103	1	j	j	PROPN
fnp-3806	5103	2	biomed	biome	VERB
fnp-3806	5103	3	sci	sci	PROPN
fnp-3806	5103	4	2020	2020	NUM
fnp-3806	5103	5	;	;	PUNCT
fnp-3806	5103	6	27:18	27:18	NUM
fnp-3806	5103	7	.	.	PUNCT
fnp-3806	5103	8	https://doi.org/10.1186/s12929-019-0609-7	https://doi.org/10.1186/s12929-019-0609-7	PROPN
fnp-3806	5103	9	cummings	cummings	PROPN
fnp-3806	5103	10	j	j	PROPN
fnp-3806	5103	11	,	,	PUNCT
fnp-3806	5103	12	lee	lee	PROPN
fnp-3806	5103	13	g	g	PROPN
fnp-3806	5103	14	,	,	PUNCT
fnp-3806	5103	15	zhong	zhong	PROPN
fnp-3806	5103	16	k	k	PROPN
fnp-3806	5103	17	,	,	PUNCT
fnp-3806	5103	18	fonseca	fonseca	PROPN
fnp-3806	5103	19	j	j	PROPN
fnp-3806	5103	20	,	,	PUNCT
fnp-3806	5103	21	et	et	PROPN
fnp-3806	5103	22	al	al	PROPN
fnp-3806	5103	23	.	.	PROPN
fnp-3806	5103	24	alzheimer	alzheimer	PROPN
fnp-3806	5103	25	’s	’s	PART
fnp-3806	5103	26	disease	disease	PROPN
fnp-3806	5103	27	drug	drug	PROPN
fnp-3806	5103	28	development	development	NOUN
fnp-3806	5103	29	pipeline	pipeline	NOUN
fnp-3806	5103	30	:	:	PUNCT
fnp-3806	5103	31	2021	2021	NUM
fnp-3806	5103	32	.	.	PUNCT
fnp-3806	5104	1	alzheimers	alzheimers	PROPN
fnp-3806	5104	2	dement	dement	PROPN
fnp-3806	5104	3	2021;7	2021;7	PROPN
fnp-3806	5104	4	:	:	PUNCT
fnp-3806	5104	5	e12179	e12179	PROPN
fnp-3806	5104	6	.	.	PUNCT
fnp-3806	5105	1	https://doi.org/10.1002/trc2.12179	https://doi.org/10.1002/trc2.12179	PROPN
fnp-3806	5105	2	mcdade	mcdade	PROPN
fnp-3806	5105	3	e	e	PROPN
fnp-3806	5105	4	,	,	PUNCT
fnp-3806	5105	5	llibre	llibre	NOUN
fnp-3806	5105	6	-	-	PUNCT
fnp-3806	5105	7	guerra	guerra	PROPN
fnp-3806	5105	8	jj	jj	PROPN
fnp-3806	5105	9	,	,	PUNCT
fnp-3806	5105	10	holtzman	holtzman	NOUN
fnp-3806	5105	11	dm	dm	PROPN
fnp-3806	5105	12	,	,	PUNCT
fnp-3806	5105	13	et	et	PROPN
fnp-3806	5105	14	al	al	PROPN
fnp-3806	5105	15	.	.	PUNCT
fnp-3806	5106	1	the	the	DET
fnp-3806	5106	2	informed	informed	ADJ
fnp-3806	5106	3	road	road	NOUN
fnp-3806	5106	4	map	map	NOUN
fnp-3806	5106	5	to	to	ADP
fnp-3806	5106	6	prevention	prevention	NOUN
fnp-3806	5106	7	of	of	ADP
fnp-3806	5106	8	alzheimer	alzheimer	PROPN
fnp-3806	5106	9	disease	disease	PROPN
fnp-3806	5106	10	:	:	PUNCT
fnp-3806	5106	11	a	a	DET
fnp-3806	5106	12	call	call	NOUN
fnp-3806	5106	13	to	to	ADP
fnp-3806	5106	14	arms	arm	NOUN
fnp-3806	5106	15	.	.	PUNCT
fnp-3806	5107	1	mol	mol	ADP
fnp-3806	5107	2	neurodegener	neurodegener	NOUN
fnp-3806	5107	3	2021;16:49	2021;16:49	NUM
fnp-3806	5107	4	.	.	PUNCT
fnp-3806	5108	1	https://doi.org/10.1186/s13024-021-00467-y	https://doi.org/10.1186/s13024-021-00467-y	PROPN
fnp-3806	5108	2	cummings	cummings	PROPN
fnp-3806	5108	3	j.	j.	PROPN
fnp-3806	5108	4	disease	disease	PROPN
fnp-3806	5108	5	modification	modification	NOUN
fnp-3806	5108	6	is	be	AUX
fnp-3806	5108	7	not	not	PART
fnp-3806	5108	8	all	all	PRON
fnp-3806	5108	9	—	—	PUNCT
fnp-3806	5108	10	we	we	PRON
fnp-3806	5108	11	need	need	VERB
fnp-3806	5108	12	symptomatic	symptomatic	ADJ
fnp-3806	5108	13	therapies	therapy	NOUN
fnp-3806	5108	14	for	for	ADP
fnp-3806	5108	15	alzheimer	alzheimer	PROPN
fnp-3806	5108	16	disease	disease	NOUN
fnp-3806	5108	17	.	.	PUNCT
fnp-3806	5109	1	nature	nature	PROPN
fnp-3806	5109	2	rev	rev	VERB
fnp-3806	5109	3	neurol	neurol	PROPN
fnp-3806	5109	4	2022;18:3	2022;18:3	PROPN
fnp-3806	5109	5	-	-	SYM
fnp-3806	5109	6	4	4	NUM
fnp-3806	5109	7	.	.	PUNCT
fnp-3806	5109	8	https://doi.org/10.1038/s41582-021-00591-9	https://doi.org/10.1038/s41582-021-00591-9	NOUN
fnp-3806	5109	9	gotz	gotz	PROPN
fnp-3806	5109	10	j	j	PROPN
fnp-3806	5109	11	,	,	PUNCT
fnp-3806	5109	12	bodea	bodea	PROPN
fnp-3806	5109	13	lg	lg	NOUN
fnp-3806	5109	14	,	,	PUNCT
fnp-3806	5109	15	goedert	goedert	ADJ
fnp-3806	5109	16	m.	m.	NOUN
fnp-3806	5109	17	rodent	rodent	NOUN
fnp-3806	5109	18	models	model	NOUN
fnp-3806	5109	19	for	for	ADP
fnp-3806	5109	20	alzheimer	alzheimer	PROPN
fnp-3806	5109	21	disease	disease	NOUN
fnp-3806	5109	22	.	.	PUNCT
fnp-3806	5110	1	nat	nat	PROPN
fnp-3806	5110	2	rev	rev	PROPN
fnp-3806	5110	3	neurosci	neurosci	PROPN
fnp-3806	5110	4	2018;9:583	2018;9:583	NUM
fnp-3806	5110	5	-	-	SYM
fnp-3806	5110	6	598	598	NUM
fnp-3806	5110	7	.	.	PUNCT
fnp-3806	5111	1	https://doi.org/10.1038/s41583-018-0054-8	https://doi.org/10.1038/s41583-018-0054-8	NUM
fnp-3806	5111	2	vitek	vitek	PROPN
fnp-3806	5111	3	mp	mp	PROPN
fnp-3806	5111	4	,	,	PUNCT
fnp-3806	5111	5	araujo	araujo	PROPN
fnp-3806	5111	6	ja	ja	PROPN
fnp-3806	5111	7	,	,	PUNCT
fnp-3806	5111	8	fossel	fossel	PROPN
fnp-3806	5111	9	m	m	PROPN
fnp-3806	5111	10	,	,	PUNCT
fnp-3806	5111	11	et	et	PROPN
fnp-3806	5111	12	al	al	PROPN
fnp-3806	5111	13	.	.	PUNCT
fnp-3806	5111	14	translational	translational	ADJ
fnp-3806	5111	15	animal	animal	NOUN
fnp-3806	5111	16	models	model	NOUN
fnp-3806	5111	17	for	for	ADP
fnp-3806	5111	18	alzheimer	alzheimer	PROPN
fnp-3806	5111	19	's	's	PART
fnp-3806	5111	20	disease	disease	NOUN
fnp-3806	5111	21	:	:	PUNCT
fnp-3806	5111	22	an	an	DET
fnp-3806	5111	23	alzheimer	alzheimer	PROPN
fnp-3806	5111	24	's	's	PART
fnp-3806	5111	25	association	association	NOUN
fnp-3806	5111	26	business	business	PROPN
fnp-3806	5111	27	consortium	consortium	PROPN
fnp-3806	5111	28	think	think	VERB
fnp-3806	5111	29	tank	tank	NOUN
fnp-3806	5111	30	.	.	PUNCT
fnp-3806	5112	1	alzheimers	alzheimers	PROPN
fnp-3806	5112	2	dement	dement	PROPN
fnp-3806	5112	3	2021;6	2021;6	PROPN
fnp-3806	5112	4	:	:	PUNCT
fnp-3806	5112	5	e12114	e12114	PROPN
fnp-3806	5112	6	.	.	PUNCT
fnp-3806	5112	7	https://doi.org/10.1002/trc2.12114	https://doi.org/10.1002/trc2.12114	X
fnp-3806	5113	1	mckean	mckean	PROPN
fnp-3806	5113	2	ne	ne	PROPN
fnp-3806	5113	3	,	,	PUNCT
fnp-3806	5113	4	handley	handley	PROPN
fnp-3806	5113	5	rr	rr	PROPN
fnp-3806	5113	6	,	,	PUNCT
fnp-3806	5113	7	snell	snell	PROPN
fnp-3806	5113	8	rg	rg	PROPN
fnp-3806	5113	9	.	.	PUNCT
fnp-3806	5114	1	a	a	DET
fnp-3806	5114	2	review	review	NOUN
fnp-3806	5114	3	of	of	ADP
fnp-3806	5114	4	the	the	DET
fnp-3806	5114	5	current	current	ADJ
fnp-3806	5114	6	mammalian	mammalian	ADJ
fnp-3806	5114	7	models	model	NOUN
fnp-3806	5114	8	of	of	ADP
fnp-3806	5114	9	alzheimer	alzheimer	PROPN
fnp-3806	5114	10	’s	’s	PART
fnp-3806	5114	11	disease	disease	NOUN
fnp-3806	5114	12	and	and	CCONJ
fnp-3806	5114	13	challenges	challenge	NOUN
fnp-3806	5114	14	that	that	PRON
fnp-3806	5114	15	need	need	VERB
fnp-3806	5114	16	to	to	PART
fnp-3806	5114	17	be	be	AUX
fnp-3806	5114	18	overcome	overcome	VERB
fnp-3806	5114	19	.	.	PUNCT
fnp-3806	5115	1	int	int	PROPN
fnp-3806	5115	2	j	j	PROPN
fnp-3806	5115	3	mol	mol	ADP
fnp-3806	5115	4	sci	sci	PROPN
fnp-3806	5115	5	2021;22:13168	2021;22:13168	PROPN
fnp-3806	5115	6	.	.	PUNCT
fnp-3806	5116	1	https://doi.org/10.3390/ijms222313168	https://doi.org/10.3390/ijms222313168	PROPN
fnp-3806	5116	2	arendt	arendt	PROPN
fnp-3806	5116	3	t.	t.	PROPN
fnp-3806	5116	4	alzheimer	alzheimer	PROPN
fnp-3806	5116	5	's	's	PART
fnp-3806	5116	6	disease	disease	NOUN
fnp-3806	5116	7	as	as	ADP
fnp-3806	5116	8	a	a	DET
fnp-3806	5116	9	disorder	disorder	NOUN
fnp-3806	5116	10	of	of	ADP
fnp-3806	5116	11	dynamic	dynamic	ADJ
fnp-3806	5116	12	brain	brain	NOUN
fnp-3806	5116	13	self	self	NOUN
fnp-3806	5116	14	-	-	PUNCT
fnp-3806	5116	15	organization	organization	NOUN
fnp-3806	5116	16	.	.	PUNCT
fnp-3806	5117	1	prog	prog	NOUN
fnp-3806	5117	2	brain	brain	NOUN
fnp-3806	5117	3	res	re	NOUN
fnp-3806	5117	4	2005;147:355	2005;147:355	NUM
fnp-3806	5117	5	-	-	SYM
fnp-3806	5117	6	378	378	NUM
fnp-3806	5117	7	.	.	PUNCT
fnp-3806	5118	1	https://doi.org/10.1016/s0079-6123(04)47025-3	https://doi.org/10.1016/s0079-6123(04)47025-3	PROPN
fnp-3806	5118	2	swerdlow	swerdlow	PROPN
fnp-3806	5118	3	rh	rh	PROPN
fnp-3806	5118	4	.	.	PROPN
fnp-3806	5118	5	alzheimer	alzheimer	PROPN
fnp-3806	5118	6	's	's	PART
fnp-3806	5118	7	disease	disease	NOUN
fnp-3806	5118	8	pathologic	pathologic	ADJ
fnp-3806	5118	9	cascades	cascade	NOUN
fnp-3806	5118	10	:	:	PUNCT
fnp-3806	5118	11	who	who	PRON
fnp-3806	5118	12	comes	come	VERB
fnp-3806	5118	13	first	first	ADV
fnp-3806	5118	14	,	,	PUNCT
fnp-3806	5118	15	what	what	PRON
fnp-3806	5118	16	drives	drive	VERB
fnp-3806	5118	17	what	what	PRON
fnp-3806	5118	18	.	.	PUNCT
fnp-3806	5119	1	neurotox	neurotox	PROPN
fnp-3806	5119	2	res	re	VERB
fnp-3806	5119	3	2012;22:182	2012;22:182	PROPN
fnp-3806	5119	4	-	-	PUNCT
fnp-3806	5119	5	194	194	NUM
fnp-3806	5119	6	.	.	PUNCT
fnp-3806	5120	1	https://doi.org/10.1007/s12640-011-9272-9	https://doi.org/10.1007/s12640-011-9272-9	NOUN
fnp-3806	5120	2	sharpee	sharpee	VERB
fnp-3806	5120	3	to	to	ADP
fnp-3806	5120	4	,	,	PUNCT
fnp-3806	5120	5	destexhe	destexhe	NOUN
fnp-3806	5120	6	a	a	PRON
fnp-3806	5120	7	,	,	PUNCT
fnp-3806	5120	8	kawato	kawato	NOUN
fnp-3806	5120	9	m	m	PROPN
fnp-3806	5120	10	,	,	PUNCT
fnp-3806	5120	11	et	et	PROPN
fnp-3806	5120	12	al	al	PROPN
fnp-3806	5120	13	.	.	PUNCT
fnp-3806	5120	14	25th	25th	PROPN
fnp-3806	5120	15	annual	annual	ADJ
fnp-3806	5120	16	computational	computational	ADJ
fnp-3806	5120	17	neuroscience	neuroscience	NOUN
fnp-3806	5120	18	meeting	meeting	NOUN
fnp-3806	5120	19	:	:	PUNCT
fnp-3806	5120	20	cns-2016	cns-2016	PROPN
fnp-3806	5120	21	.	.	PUNCT
fnp-3806	5121	1	bmc	bmc	PROPN
fnp-3806	5121	2	neurosci	neurosci	PROPN
fnp-3806	5121	3	2016;17	2016;17	NUM
fnp-3806	5121	4	suppl	suppl	ADJ
fnp-3806	5121	5	1:54	1:54	NUM
fnp-3806	5121	6	.	.	PUNCT
fnp-3806	5122	1	https://doi.org/10.1186/s12868-016-0283-6	https://doi.org/10.1186/s12868-016-0283-6	PROPN
fnp-3806	5123	1	bashtrykov	bashtrykov	PROPN
fnp-3806	5123	2	p	p	X
fnp-3806	5123	3	,	,	PUNCT
fnp-3806	5123	4	jeltsch	jeltsch	ADJ
fnp-3806	5123	5	a.	a.	NOUN
fnp-3806	5123	6	epigenome	epigenome	NOUN
fnp-3806	5123	7	editing	editing	NOUN
fnp-3806	5123	8	in	in	ADP
fnp-3806	5123	9	the	the	DET
fnp-3806	5123	10	brain	brain	NOUN
fnp-3806	5123	11	.	.	PUNCT
fnp-3806	5124	1	adv	adv	PROPN
fnp-3806	5124	2	exp	exp	NOUN
fnp-3806	5124	3	med	me	VERB
fnp-3806	5124	4	biol	biol	NOUN
fnp-3806	5124	5	2017;978:409	2017;978:409	NUM
fnp-3806	5124	6	-	-	SYM
fnp-3806	5124	7	424	424	NUM
fnp-3806	5124	8	.	.	PUNCT
fnp-3806	5125	1	https://doi.org/10.1007/978-3-319-53889-1_21	https://doi.org/10.1007/978-3-319-53889-1_21	PROPN
fnp-3806	5125	2	mancioppi	mancioppi	PROPN
fnp-3806	5125	3	g	g	PROPN
fnp-3806	5125	4	,	,	PUNCT
fnp-3806	5125	5	fiorini	fiorini	PROPN
fnp-3806	5125	6	l	l	NOUN
fnp-3806	5125	7	,	,	PUNCT
fnp-3806	5125	8	timpano	timpano	PROPN
fnp-3806	5125	9	sportiello	sportiello	VERB
fnp-3806	5125	10	m	m	PROPN
fnp-3806	5125	11	,	,	PUNCT
fnp-3806	5125	12	et	et	PROPN
fnp-3806	5125	13	al	al	PROPN
fnp-3806	5125	14	.	.	PROPN
fnp-3806	5126	1	novel	novel	ADJ
fnp-3806	5126	2	technological	technological	ADJ
fnp-3806	5126	3	solutions	solution	NOUN
fnp-3806	5126	4	for	for	ADP
fnp-3806	5126	5	assessment	assessment	NOUN
fnp-3806	5126	6	,	,	PUNCT
fnp-3806	5126	7	treatment	treatment	NOUN
fnp-3806	5126	8	,	,	PUNCT
fnp-3806	5126	9	and	and	CCONJ
fnp-3806	5126	10	assistance	assistance	NOUN
fnp-3806	5126	11	in	in	ADP
fnp-3806	5126	12	mild	mild	ADJ
fnp-3806	5126	13	cognitive	cognitive	ADJ
fnp-3806	5126	14	impairment	impairment	NOUN
fnp-3806	5126	15	.	.	PUNCT
fnp-3806	5127	1	front	front	ADJ
fnp-3806	5127	2	neuroinform	neuroinform	NOUN
fnp-3806	5127	3	2019;13:58	2019;13:58	NUM
fnp-3806	5127	4	.	.	PUNCT
fnp-3806	5128	1	https://doi.org/10.3389/fninf.2019.00058	https://doi.org/10.3389/fninf.2019.00058	NOUN
fnp-3806	5128	2	romanella	romanella	NOUN
fnp-3806	5128	3	sm	sm	PROPN
fnp-3806	5128	4	,	,	PUNCT
fnp-3806	5128	5	roe	roe	PROPN
fnp-3806	5128	6	d	d	PROPN
fnp-3806	5128	7	,	,	PUNCT
fnp-3806	5128	8	paciorek	paciorek	PROPN
fnp-3806	5128	9	r	r	NOUN
fnp-3806	5128	10	,	,	PUNCT
fnp-3806	5128	11	et	et	PROPN
fnp-3806	5128	12	al	al	PROPN
fnp-3806	5128	13	.	.	PUNCT
fnp-3806	5128	14	sleep	sleep	PROPN
fnp-3806	5128	15	,	,	PUNCT
fnp-3806	5128	16	noninvasive	noninvasive	ADJ
fnp-3806	5128	17	brain	brain	NOUN
fnp-3806	5128	18	stimulation	stimulation	NOUN
fnp-3806	5128	19	,	,	PUNCT
fnp-3806	5128	20	and	and	CCONJ
fnp-3806	5128	21	the	the	DET
fnp-3806	5128	22	aging	age	VERB
fnp-3806	5128	23	brain	brain	NOUN
fnp-3806	5128	24	:	:	PUNCT
fnp-3806	5128	25	challenges	challenge	NOUN
fnp-3806	5128	26	and	and	CCONJ
fnp-3806	5128	27	opportunities	opportunity	NOUN
fnp-3806	5128	28	.	.	PUNCT
fnp-3806	5129	1	ageing	age	VERB
fnp-3806	5129	2	res	re	NOUN
fnp-3806	5129	3	rev	rev	VERB
fnp-3806	5129	4	2020;61:101067	2020;61:101067	NUM
fnp-3806	5129	5	.	.	PUNCT
fnp-3806	5130	1	https://doi.org/10.1016/j.arr.2020.101067	https://doi.org/10.1016/j.arr.2020.101067	PROPN
fnp-3806	5130	2	el	el	PROPN
fnp-3806	5130	3	-	-	PUNCT
fnp-3806	5130	4	atab	atab	NOUN
fnp-3806	5130	5	n	n	CCONJ
fnp-3806	5130	6	,	,	PUNCT
fnp-3806	5130	7	shaikh	shaikh	PROPN
fnp-3806	5130	8	sf	sf	PROPN
fnp-3806	5130	9	,	,	PUNCT
fnp-3806	5130	10	hussain	hussain	PROPN
fnp-3806	5130	11	mm	mm	PROPN
fnp-3806	5130	12	.	.	PUNCT
fnp-3806	5130	13	nano	nano	NOUN
fnp-3806	5130	14	-	-	PUNCT
fnp-3806	5130	15	scale	scale	NOUN
fnp-3806	5130	16	transistors	transistor	NOUN
fnp-3806	5130	17	for	for	ADP
fnp-3806	5130	18	interfacing	interface	VERB
fnp-3806	5130	19	with	with	ADP
fnp-3806	5130	20	brain	brain	NOUN
fnp-3806	5130	21	:	:	PUNCT
fnp-3806	5130	22	design	design	NOUN
fnp-3806	5130	23	criteria	criterion	NOUN
fnp-3806	5130	24	,	,	PUNCT
fnp-3806	5130	25	progress	progress	NOUN
fnp-3806	5130	26	and	and	CCONJ
fnp-3806	5130	27	prospect	prospect	NOUN
fnp-3806	5130	28	.	.	PUNCT
fnp-3806	5131	1	nanotechnology	nanotechnology	PROPN
fnp-3806	5131	2	2019;30:442001	2019;30:442001	NUM
fnp-3806	5131	3	.	.	PUNCT
fnp-3806	5132	1	https://doi.org/10.1088/1361-6528/ab3534	https://doi.org/10.1088/1361-6528/ab3534	ADP
fnp-3806	5132	2	koutentakis	koutentaki	NOUN
fnp-3806	5132	3	d	d	NOUN
fnp-3806	5132	4	,	,	PUNCT
fnp-3806	5132	5	pilozzi	pilozzi	NOUN
fnp-3806	5132	6	a	a	NOUN
fnp-3806	5132	7	,	,	PUNCT
fnp-3806	5132	8	huang	huang	PROPN
fnp-3806	5132	9	x.	x.	PROPN
fnp-3806	5132	10	designing	design	VERB
fnp-3806	5132	11	socially	socially	ADV
fnp-3806	5132	12	assistive	assistive	ADJ
fnp-3806	5132	13	robots	robot	NOUN
fnp-3806	5132	14	for	for	ADP
fnp-3806	5132	15	alzheimer	alzheimer	PROPN
fnp-3806	5132	16	’s	’s	PART
fnp-3806	5132	17	disease	disease	NOUN
fnp-3806	5132	18	and	and	CCONJ
fnp-3806	5132	19	related	related	ADJ
fnp-3806	5132	20	dementia	dementia	NOUN
fnp-3806	5132	21	patients	patient	NOUN
fnp-3806	5132	22	and	and	CCONJ
fnp-3806	5132	23	their	their	PRON
fnp-3806	5132	24	caregivers	caregiver	NOUN
fnp-3806	5132	25	:	:	PUNCT
fnp-3806	5132	26	where	where	SCONJ
fnp-3806	5132	27	we	we	PRON
fnp-3806	5132	28	are	be	AUX
fnp-3806	5132	29	and	and	CCONJ
fnp-3806	5132	30	where	where	SCONJ
fnp-3806	5132	31	we	we	PRON
fnp-3806	5132	32	are	be	AUX
fnp-3806	5132	33	headed	head	VERB
fnp-3806	5132	34	.	.	PUNCT
fnp-3806	5133	1	healthcare	healthcare	PROPN
fnp-3806	5133	2	2020;8:73	2020;8:73	PROPN
fnp-3806	5133	3	.	.	PUNCT
fnp-3806	5134	1	https://doi.org/10.3390/healthcare8020073	https://doi.org/10.3390/healthcare8020073	NOUN
fnp-3806	5134	2	ling	ling	PROPN
fnp-3806	5134	3	ts	ts	PROPN
fnp-3806	5134	4	,	,	PUNCT
fnp-3806	5134	5	chandrasegaran	chandrasegaran	VERB
fnp-3806	5134	6	s	s	PROPN
fnp-3806	5134	7	,	,	PUNCT
fnp-3806	5134	8	xuan	xuan	PROPN
fnp-3806	5134	9	lz	lz	PROPN
fnp-3806	5134	10	,	,	PUNCT
fnp-3806	5134	11	et	et	PROPN
fnp-3806	5134	12	al	al	PROPN
fnp-3806	5134	13	.	.	PUNCT
fnp-3806	5135	1	the	the	DET
fnp-3806	5135	2	potential	potential	ADJ
fnp-3806	5135	3	benefits	benefit	NOUN
fnp-3806	5135	4	of	of	ADP
fnp-3806	5135	5	nanotechnology	nanotechnology	NOUN
fnp-3806	5135	6	in	in	ADP
fnp-3806	5135	7	treating	treat	VERB
fnp-3806	5135	8	alzheimer	alzheimer	NOUN
fnp-3806	5135	9	's	's	PART
fnp-3806	5135	10	disease	disease	NOUN
fnp-3806	5135	11	.	.	PUNCT
fnp-3806	5135	12	biomed	biome	VERB
fnp-3806	5135	13	res	re	NOUN
fnp-3806	5135	14	int	int	NOUN
fnp-3806	5135	15	2021;2021:5550938	2021;2021:5550938	NUM
fnp-3806	5135	16	.	.	PUNCT
fnp-3806	5136	1	https://doi.org/10.1155/2021/5550938	https://doi.org/10.1155/2021/5550938	ADJ
fnp-3806	5136	2	copyright	copyright	NOUN
fnp-3806	5136	3	:	:	PUNCT
fnp-3806	5136	4	©	©	PROPN
fnp-3806	5136	5	2022	2022	NUM
fnp-3806	5136	6	the	the	DET
fnp-3806	5136	7	author(s	author(s	NOUN
fnp-3806	5136	8	)	)	PUNCT
fnp-3806	5136	9	.	.	PUNCT
fnp-3806	5137	1	this	this	PRON
fnp-3806	5137	2	is	be	AUX
fnp-3806	5137	3	an	an	DET
fnp-3806	5137	4	open	open	ADJ
fnp-3806	5137	5	access	access	NOUN
fnp-3806	5137	6	article	article	NOUN
fnp-3806	5137	7	distributed	distribute	VERB
fnp-3806	5137	8	under	under	ADP
fnp-3806	5137	9	the	the	DET
fnp-3806	5137	10	terms	term	NOUN
fnp-3806	5137	11	of	of	ADP
fnp-3806	5137	12	the	the	DET
fnp-3806	5137	13	creative	creative	ADJ
fnp-3806	5137	14	commons	common	NOUN
fnp-3806	5137	15	attribution	attribution	NOUN
fnp-3806	5137	16	4.0	4.0	NUM
fnp-3806	5137	17	international	international	ADJ
fnp-3806	5137	18	license	license	NOUN
fnp-3806	5137	19	(	(	PUNCT
fnp-3806	5137	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-3806	5137	21	)	)	PUNCT
fnp-3806	5137	22	,	,	PUNCT
fnp-3806	5137	23	which	which	PRON
fnp-3806	5137	24	permits	permit	VERB
fnp-3806	5137	25	unrestricted	unrestricted	ADJ
fnp-3806	5137	26	use	use	NOUN
fnp-3806	5137	27	,	,	PUNCT
fnp-3806	5137	28	distribution	distribution	NOUN
fnp-3806	5137	29	,	,	PUNCT
fnp-3806	5137	30	and	and	CCONJ
fnp-3806	5137	31	reproduction	reproduction	NOUN
fnp-3806	5137	32	in	in	ADP
fnp-3806	5137	33	any	any	DET
fnp-3806	5137	34	medium	medium	NOUN
fnp-3806	5137	35	,	,	PUNCT
fnp-3806	5137	36	provided	provide	VERB
fnp-3806	5137	37	the	the	DET
fnp-3806	5137	38	original	original	ADJ
fnp-3806	5137	39	author	author	NOUN
fnp-3806	5137	40	and	and	CCONJ
fnp-3806	5137	41	source	source	NOUN
fnp-3806	5137	42	are	be	AUX
fnp-3806	5137	43	credited	credit	VERB
fnp-3806	5137	44	,	,	PUNCT
fnp-3806	5137	45	a	a	DET
fnp-3806	5137	46	link	link	NOUN
fnp-3806	5137	47	to	to	ADP
fnp-3806	5137	48	the	the	DET
fnp-3806	5137	49	creative	creative	ADJ
fnp-3806	5137	50	commons	common	NOUN
fnp-3806	5137	51	license	license	NOUN
fnp-3806	5137	52	is	be	AUX
fnp-3806	5137	53	provided	provide	VERB
fnp-3806	5137	54	,	,	PUNCT
fnp-3806	5137	55	and	and	CCONJ
fnp-3806	5137	56	any	any	DET
fnp-3806	5137	57	changes	change	NOUN
fnp-3806	5137	58	are	be	AUX
fnp-3806	5137	59	indicated	indicate	VERB
fnp-3806	5137	60	.	.	PUNCT
fnp-3806	5138	1	the	the	DET
fnp-3806	5138	2	creative	creative	ADJ
fnp-3806	5138	3	commons	common	NOUN
fnp-3806	5138	4	public	public	ADJ
fnp-3806	5138	5	domain	domain	NOUN
fnp-3806	5138	6	dedication	dedication	NOUN
fnp-3806	5138	7	waiver	waiver	NOUN
fnp-3806	5138	8	(	(	PUNCT
fnp-3806	5138	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-3806	5138	10	)	)	PUNCT
fnp-3806	5138	11	applies	apply	VERB
fnp-3806	5138	12	to	to	ADP
fnp-3806	5138	13	the	the	DET
fnp-3806	5138	14	data	datum	NOUN
fnp-3806	5138	15	made	make	VERB
fnp-3806	5138	16	available	available	ADJ
fnp-3806	5138	17	in	in	ADP
fnp-3806	5138	18	this	this	DET
fnp-3806	5138	19	article	article	NOUN
fnp-3806	5138	20	,	,	PUNCT
fnp-3806	5138	21	unless	unless	SCONJ
fnp-3806	5138	22	otherwise	otherwise	ADV
fnp-3806	5138	23	stated	state	VERB
fnp-3806	5138	24	.	.	PUNCT