id	sid	tid	token	lemma	pos
fnp-3910	1	1	neurovascular	neurovascular	ADJ
fnp-3910	1	2	disease	disease	NOUN
fnp-3910	1	3	:	:	PUNCT
fnp-3910	1	4	2022	2022	NUM
fnp-3910	1	5	update	update	NOUN
fnp-3910	1	6	feel	feel	VERB
fnp-3910	1	7	free	free	ADJ
fnp-3910	1	8	to	to	PART
fnp-3910	1	9	add	add	VERB
fnp-3910	1	10	comments	comment	NOUN
fnp-3910	1	11	by	by	ADP
fnp-3910	1	12	clicking	click	VERB
fnp-3910	1	13	these	these	DET
fnp-3910	1	14	icons	icon	NOUN
fnp-3910	1	15	on	on	ADP
fnp-3910	1	16	the	the	DET
fnp-3910	1	17	sidebar	sidebar	NOUN
fnp-3910	1	18	free	free	ADJ
fnp-3910	1	19	neuropathology	neuropathology	NOUN
fnp-3910	1	20	3:15	3:15	NUM
fnp-3910	1	21	(	(	PUNCT
fnp-3910	1	22	2022	2022	NUM
fnp-3910	1	23	)	)	PUNCT
fnp-3910	1	24	review	review	VERB
fnp-3910	1	25	neurovascular	neurovascular	ADJ
fnp-3910	1	26	disease	disease	NOUN
fnp-3910	1	27	:	:	PUNCT
fnp-3910	1	28	2022	2022	NUM
fnp-3910	1	29	update	update	NOUN
fnp-3910	1	30	louise	louise	PROPN
fnp-3910	1	31	d.	d.	PROPN
fnp-3910	1	32	mccullough	mccullough	PROPN
fnp-3910	1	33	department	department	PROPN
fnp-3910	1	34	of	of	ADP
fnp-3910	1	35	neurology	neurology	NOUN
fnp-3910	1	36	,	,	PUNCT
fnp-3910	1	37	mcgovern	mcgovern	PROPN
fnp-3910	1	38	medical	medical	ADJ
fnp-3910	1	39	school	school	PROPN
fnp-3910	1	40	,	,	PUNCT
fnp-3910	1	41	uthealth	uthealth	PROPN
fnp-3910	1	42	houston	houston	PROPN
fnp-3910	1	43	and	and	CCONJ
fnp-3910	1	44	memorial	memorial	ADJ
fnp-3910	1	45	hermann	hermann	PROPN
fnp-3910	1	46	hospital	hospital	PROPN
fnp-3910	1	47	,	,	PUNCT
fnp-3910	1	48	houston	houston	PROPN
fnp-3910	1	49	,	,	PUNCT
fnp-3910	1	50	texas	texas	PROPN
fnp-3910	1	51	,	,	PUNCT
fnp-3910	1	52	usa	usa	PROPN
fnp-3910	1	53	corresponding	corresponding	PROPN
fnp-3910	1	54	author	author	NOUN
fnp-3910	1	55	:	:	PUNCT
fnp-3910	1	56	louise	louise	PROPN
fnp-3910	1	57	d.	d.	PROPN
fnp-3910	1	58	mccullough	mccullough	PROPN
fnp-3910	1	59	·	·	PUNCT
fnp-3910	1	60	department	department	PROPN
fnp-3910	1	61	of	of	ADP
fnp-3910	1	62	neurology	neurology	NOUN
fnp-3910	1	63	·	·	PUNCT
fnp-3910	1	64	mcgovern	mcgovern	PROPN
fnp-3910	1	65	medical	medical	ADJ
fnp-3910	1	66	school	school	NOUN
fnp-3910	1	67	·	·	PUNCT
fnp-3910	1	68	uthealth	uthealth	ADJ
fnp-3910	1	69	houston	houston	PROPN
fnp-3910	1	70	and	and	CCONJ
fnp-3910	1	71	memorial	memorial	ADJ
fnp-3910	1	72	hermann	hermann	PROPN
fnp-3910	1	73	hospital	hospital	PROPN
fnp-3910	1	74	·	·	PUNCT
fnp-3910	1	75	houston	houston	PROPN
fnp-3910	1	76	,	,	PUNCT
fnp-3910	1	77	texas	texas	PROPN
fnp-3910	1	78	·	·	SYM
fnp-3910	1	79	usa	usa	PROPN
fnp-3910	1	80	louise.d.mccullough@uth.tmc.edu	louise.d.mccullough@uth.tmc.edu	PROPN
fnp-3910	1	81	submitted	submit	VERB
fnp-3910	1	82	:	:	PUNCT
fnp-3910	1	83	25	25	NUM
fnp-3910	1	84	april	april	PROPN
fnp-3910	1	85	2022	2022	NUM
fnp-3910	1	86	accepted	accept	VERB
fnp-3910	1	87	:	:	PUNCT
fnp-3910	1	88	07	07	NUM
fnp-3910	1	89	june	june	PROPN
fnp-3910	1	90	2022	2022	NUM
fnp-3910	1	91	copyedited	copyedit	VERB
fnp-3910	1	92	by	by	ADP
fnp-3910	1	93	:	:	PUNCT
fnp-3910	1	94	félicia	félicia	PROPN
fnp-3910	1	95	jeannelle	jeannelle	NOUN
fnp-3910	1	96	published	publish	VERB
fnp-3910	1	97	:	:	PUNCT
fnp-3910	1	98	14	14	NUM
fnp-3910	1	99	june	june	PROPN
fnp-3910	1	100	2022	2022	NUM
fnp-3910	1	101	https://doi.org/10.17879/freeneuropathology-2022-3910	https://doi.org/10.17879/freeneuropathology-2022-3910	VERB
fnp-3910	1	102	keywords	keyword	NOUN
fnp-3910	1	103	:	:	PUNCT
fnp-3910	1	104	stroke	stroke	NOUN
fnp-3910	1	105	,	,	PUNCT
fnp-3910	1	106	vascular	vascular	ADJ
fnp-3910	1	107	malformations	malformation	NOUN
fnp-3910	1	108	,	,	PUNCT
fnp-3910	1	109	microglia	microglia	NOUN
fnp-3910	1	110	,	,	PUNCT
fnp-3910	1	111	t	t	NOUN
fnp-3910	1	112	cells	cell	NOUN
fnp-3910	1	113	,	,	PUNCT
fnp-3910	1	114	neuroinflammation	neuroinflammation	NOUN
fnp-3910	1	115	abstract	abstract	NOUN
fnp-3910	1	116	in	in	ADP
fnp-3910	1	117	this	this	DET
fnp-3910	1	118	update	update	NOUN
fnp-3910	1	119	we	we	PRON
fnp-3910	1	120	present	present	VERB
fnp-3910	1	121	a	a	DET
fnp-3910	1	122	series	series	NOUN
fnp-3910	1	123	of	of	ADP
fnp-3910	1	124	papers	paper	NOUN
fnp-3910	1	125	focused	focus	VERB
fnp-3910	1	126	on	on	ADP
fnp-3910	1	127	topics	topic	NOUN
fnp-3910	1	128	that	that	PRON
fnp-3910	1	129	have	have	AUX
fnp-3910	1	130	emerged	emerge	VERB
fnp-3910	1	131	in	in	ADP
fnp-3910	1	132	vascular	vascular	ADJ
fnp-3910	1	133	disease	disease	NOUN
fnp-3910	1	134	over	over	ADP
fnp-3910	1	135	the	the	DET
fnp-3910	1	136	prior	prior	ADJ
fnp-3910	1	137	year	year	NOUN
fnp-3910	1	138	.	.	PUNCT
fnp-3910	2	1	the	the	DET
fnp-3910	2	2	first	first	ADJ
fnp-3910	2	3	two	two	NUM
fnp-3910	2	4	papers	paper	NOUN
fnp-3910	2	5	focus	focus	VERB
fnp-3910	2	6	on	on	ADP
fnp-3910	2	7	the	the	DET
fnp-3910	2	8	pathogenesis	pathogenesis	NOUN
fnp-3910	2	9	of	of	ADP
fnp-3910	2	10	vascular	vascular	ADJ
fnp-3910	2	11	malformations	malformation	NOUN
fnp-3910	2	12	,	,	PUNCT
fnp-3910	2	13	the	the	DET
fnp-3910	2	14	first	first	ADJ
fnp-3910	2	15	on	on	ADP
fnp-3910	2	16	brain	brain	NOUN
fnp-3910	2	17	arteriovenous	arteriovenous	ADJ
fnp-3910	2	18	malformations	malformation	NOUN
fnp-3910	2	19	,	,	PUNCT
fnp-3910	2	20	and	and	CCONJ
fnp-3910	2	21	the	the	DET
fnp-3910	2	22	second	second	ADJ
fnp-3910	2	23	on	on	ADP
fnp-3910	2	24	cerebral	cerebral	ADJ
fnp-3910	2	25	cavernous	cavernous	ADJ
fnp-3910	2	26	malformations	malformation	NOUN
fnp-3910	2	27	.	.	PUNCT
fnp-3910	3	1	these	these	DET
fnp-3910	3	2	disorders	disorder	NOUN
fnp-3910	3	3	can	can	AUX
fnp-3910	3	4	lead	lead	VERB
fnp-3910	3	5	to	to	ADP
fnp-3910	3	6	significant	significant	ADJ
fnp-3910	3	7	brain	brain	NOUN
fnp-3910	3	8	injuries	injury	NOUN
fnp-3910	3	9	from	from	ADP
fnp-3910	3	10	intracerebral	intracerebral	ADJ
fnp-3910	3	11	hemorrhage	hemorrhage	NOUN
fnp-3910	3	12	(	(	PUNCT
fnp-3910	3	13	if	if	SCONJ
fnp-3910	3	14	they	they	PRON
fnp-3910	3	15	rupture	rupture	VERB
fnp-3910	3	16	)	)	PUNCT
fnp-3910	3	17	or	or	CCONJ
fnp-3910	3	18	other	other	ADJ
fnp-3910	3	19	neurological	neurological	ADJ
fnp-3910	3	20	complications	complication	NOUN
fnp-3910	3	21	,	,	PUNCT
fnp-3910	3	22	including	include	VERB
fnp-3910	3	23	seizures	seizure	NOUN
fnp-3910	3	24	.	.	PUNCT
fnp-3910	4	1	the	the	DET
fnp-3910	4	2	next	next	ADJ
fnp-3910	4	3	set	set	NOUN
fnp-3910	4	4	of	of	ADP
fnp-3910	4	5	papers	paper	NOUN
fnp-3910	4	6	reflects	reflect	VERB
fnp-3910	4	7	work	work	NOUN
fnp-3910	4	8	that	that	PRON
fnp-3910	4	9	has	have	AUX
fnp-3910	4	10	advanced	advance	VERB
fnp-3910	4	11	our	our	PRON
fnp-3910	4	12	understanding	understanding	NOUN
fnp-3910	4	13	of	of	ADP
fnp-3910	4	14	how	how	SCONJ
fnp-3910	4	15	the	the	DET
fnp-3910	4	16	brain	brain	NOUN
fnp-3910	4	17	and	and	CCONJ
fnp-3910	4	18	the	the	DET
fnp-3910	4	19	immune	immune	ADJ
fnp-3910	4	20	system	system	NOUN
fnp-3910	4	21	“	"	PUNCT
fnp-3910	4	22	communicate	communicate	VERB
fnp-3910	4	23	”	"	PUNCT
fnp-3910	4	24	after	after	ADP
fnp-3910	4	25	brain	brain	NOUN
fnp-3910	4	26	injury	injury	NOUN
fnp-3910	4	27	,	,	PUNCT
fnp-3910	4	28	including	include	VERB
fnp-3910	4	29	stroke	stroke	NOUN
fnp-3910	4	30	(	(	PUNCT
fnp-3910	4	31	papers	paper	NOUN
fnp-3910	4	32	3	3	NUM
fnp-3910	4	33	-	-	SYM
fnp-3910	4	34	6	6	NUM
fnp-3910	4	35	)	)	PUNCT
fnp-3910	4	36	.	.	PUNCT
fnp-3910	5	1	the	the	DET
fnp-3910	5	2	first	first	ADJ
fnp-3910	5	3	of	of	ADP
fnp-3910	5	4	these	these	PRON
fnp-3910	5	5	shows	show	NOUN
fnp-3910	5	6	that	that	SCONJ
fnp-3910	5	7	t	t	PROPN
fnp-3910	5	8	cells	cell	NOUN
fnp-3910	5	9	are	be	AUX
fnp-3910	5	10	involved	involve	VERB
fnp-3910	5	11	in	in	ADP
fnp-3910	5	12	white	white	ADJ
fnp-3910	5	13	matter	matter	NOUN
fnp-3910	5	14	repair	repair	NOUN
fnp-3910	5	15	after	after	ADP
fnp-3910	5	16	ischemic	ischemic	ADJ
fnp-3910	5	17	injury	injury	NOUN
fnp-3910	5	18	,	,	PUNCT
fnp-3910	5	19	an	an	DET
fnp-3910	5	20	effect	effect	NOUN
fnp-3910	5	21	dependent	dependent	ADJ
fnp-3910	5	22	on	on	ADP
fnp-3910	5	23	microglia	microglia	NOUN
fnp-3910	5	24	,	,	PUNCT
fnp-3910	5	25	demonstrating	demonstrate	VERB
fnp-3910	5	26	the	the	DET
fnp-3910	5	27	important	important	ADJ
fnp-3910	5	28	cross	cross	NOUN
fnp-3910	5	29	-	-	NOUN
fnp-3910	5	30	talk	talk	NOUN
fnp-3910	5	31	between	between	ADP
fnp-3910	5	32	innate	innate	ADJ
fnp-3910	5	33	and	and	CCONJ
fnp-3910	5	34	adaptive	adaptive	ADJ
fnp-3910	5	35	immunity	immunity	NOUN
fnp-3910	5	36	.	.	PUNCT
fnp-3910	6	1	the	the	DET
fnp-3910	6	2	next	next	ADJ
fnp-3910	6	3	two	two	NUM
fnp-3910	6	4	papers	paper	NOUN
fnp-3910	6	5	focus	focus	VERB
fnp-3910	6	6	on	on	ADP
fnp-3910	6	7	b	b	NOUN
fnp-3910	6	8	cells	cell	NOUN
fnp-3910	6	9	,	,	PUNCT
fnp-3910	6	10	which	which	PRON
fnp-3910	6	11	have	have	AUX
fnp-3910	6	12	been	be	AUX
fnp-3910	6	13	relatively	relatively	ADV
fnp-3910	6	14	understudied	understudied	ADJ
fnp-3910	6	15	in	in	ADP
fnp-3910	6	16	the	the	DET
fnp-3910	6	17	context	context	NOUN
fnp-3910	6	18	of	of	ADP
fnp-3910	6	19	brain	brain	NOUN
fnp-3910	6	20	injury	injury	NOUN
fnp-3910	6	21	.	.	PUNCT
fnp-3910	7	1	the	the	DET
fnp-3910	7	2	contribution	contribution	NOUN
fnp-3910	7	3	of	of	ADP
fnp-3910	7	4	antigen	antigen	ADV
fnp-3910	7	5	-	-	PUNCT
fnp-3910	7	6	experienced	experience	VERB
fnp-3910	7	7	b	b	NOUN
fnp-3910	7	8	cells	cell	NOUN
fnp-3910	7	9	from	from	ADP
fnp-3910	7	10	the	the	DET
fnp-3910	7	11	meninges	meninge	NOUN
fnp-3910	7	12	and	and	CCONJ
fnp-3910	7	13	skull	skull	NOUN
fnp-3910	7	14	bone	bone	NOUN
fnp-3910	7	15	marrow	marrow	NOUN
fnp-3910	7	16	,	,	PUNCT
fnp-3910	7	17	rather	rather	ADV
fnp-3910	7	18	than	than	ADP
fnp-3910	7	19	blood	blood	NOUN
fnp-3910	7	20	-	-	PUNCT
fnp-3910	7	21	derived	derive	VERB
fnp-3910	7	22	b	b	NOUN
fnp-3910	7	23	cells	cell	NOUN
fnp-3910	7	24	in	in	ADP
fnp-3910	7	25	neuroinflammation	neuroinflammation	NOUN
fnp-3910	7	26	opens	open	VERB
fnp-3910	7	27	up	up	ADP
fnp-3910	7	28	a	a	DET
fnp-3910	7	29	very	very	ADV
fnp-3910	7	30	novel	novel	ADJ
fnp-3910	7	31	area	area	NOUN
fnp-3910	7	32	of	of	ADP
fnp-3910	7	33	investigation	investigation	NOUN
fnp-3910	7	34	.	.	PUNCT
fnp-3910	8	1	the	the	DET
fnp-3910	8	2	possibility	possibility	NOUN
fnp-3910	8	3	that	that	SCONJ
fnp-3910	8	4	antibody	antibody	NOUN
fnp-3910	8	5	secreting	secrete	VERB
fnp-3910	8	6	b	b	NOUN
fnp-3910	8	7	cells	cell	NOUN
fnp-3910	8	8	may	may	AUX
fnp-3910	8	9	contribute	contribute	VERB
fnp-3910	8	10	to	to	ADP
fnp-3910	8	11	vascular	vascular	ADJ
fnp-3910	8	12	dementia	dementia	NOUN
fnp-3910	8	13	will	will	AUX
fnp-3910	8	14	certainly	certainly	ADV
fnp-3910	8	15	be	be	AUX
fnp-3910	8	16	an	an	DET
fnp-3910	8	17	active	active	ADJ
fnp-3910	8	18	area	area	NOUN
fnp-3910	8	19	for	for	ADP
fnp-3910	8	20	future	future	ADJ
fnp-3910	8	21	investigations	investigation	NOUN
fnp-3910	8	22	.	.	PUNCT
fnp-3910	9	1	similarly	similarly	ADV
fnp-3910	9	2	,	,	PUNCT
fnp-3910	9	3	in	in	ADP
fnp-3910	9	4	paper	paper	NOUN
fnp-3910	9	5	6	6	NUM
fnp-3910	9	6	,	,	PUNCT
fnp-3910	9	7	investigators	investigator	NOUN
fnp-3910	9	8	found	find	VERB
fnp-3910	9	9	that	that	SCONJ
fnp-3910	9	10	cns	cns	NOUN
fnp-3910	9	11	-	-	PUNCT
fnp-3910	9	12	infiltrating	infiltrating	ADJ
fnp-3910	9	13	myeloid	myeloid	ADJ
fnp-3910	9	14	cells	cell	NOUN
fnp-3910	9	15	can	can	AUX
fnp-3910	9	16	originate	originate	VERB
fnp-3910	9	17	from	from	ADP
fnp-3910	9	18	brain	brain	NOUN
fnp-3910	9	19	borders	border	NOUN
fnp-3910	9	20	tissues	tissue	NOUN
fnp-3910	9	21	.	.	PUNCT
fnp-3910	10	1	these	these	DET
fnp-3910	10	2	cells	cell	NOUN
fnp-3910	10	3	have	have	VERB
fnp-3910	10	4	unique	unique	ADJ
fnp-3910	10	5	transcriptional	transcriptional	ADJ
fnp-3910	10	6	signatures	signature	NOUN
fnp-3910	10	7	that	that	PRON
fnp-3910	10	8	are	be	AUX
fnp-3910	10	9	distinct	distinct	ADJ
fnp-3910	10	10	from	from	ADP
fnp-3910	10	11	their	their	PRON
fnp-3910	10	12	blood	blood	NOUN
fnp-3910	10	13	-	-	PUNCT
fnp-3910	10	14	derived	derive	VERB
fnp-3910	10	15	counterparts	counterpart	NOUN
fnp-3910	10	16	,	,	PUNCT
fnp-3910	10	17	and	and	CCONJ
fnp-3910	10	18	likely	likely	ADV
fnp-3910	10	19	contribute	contribute	VERB
fnp-3910	10	20	to	to	ADP
fnp-3910	10	21	myeloid	myeloid	NOUN
fnp-3910	10	22	cell	cell	NOUN
fnp-3910	10	23	infiltration	infiltration	NOUN
fnp-3910	10	24	from	from	ADP
fnp-3910	10	25	bone	bone	NOUN
fnp-3910	10	26	-	-	PUNCT
fnp-3910	10	27	marrow	marrow	NOUN
fnp-3910	10	28	niches	niche	NOUN
fnp-3910	10	29	in	in	ADP
fnp-3910	10	30	close	close	ADJ
fnp-3910	10	31	proximity	proximity	NOUN
fnp-3910	10	32	to	to	ADP
fnp-3910	10	33	the	the	DET
fnp-3910	10	34	brain	brain	NOUN
fnp-3910	10	35	.	.	PUNCT
fnp-3910	11	1	the	the	DET
fnp-3910	11	2	contribution	contribution	NOUN
fnp-3910	11	3	of	of	ADP
fnp-3910	11	4	microglia	microglia	NOUN
fnp-3910	11	5	,	,	PUNCT
fnp-3910	11	6	the	the	DET
fnp-3910	11	7	primary	primary	ADJ
fnp-3910	11	8	innate	innate	ADJ
fnp-3910	11	9	immune	immune	ADJ
fnp-3910	11	10	cell	cell	NOUN
fnp-3910	11	11	of	of	ADP
fnp-3910	11	12	the	the	DET
fnp-3910	11	13	brain	brain	NOUN
fnp-3910	11	14	,	,	PUNCT
fnp-3910	11	15	to	to	PART
fnp-3910	11	16	amyloid	amyloid	VERB
fnp-3910	11	17	deposition	deposition	NOUN
fnp-3910	11	18	and	and	CCONJ
fnp-3910	11	19	propagation	propagation	NOUN
fnp-3910	11	20	is	be	AUX
fnp-3910	11	21	then	then	ADV
fnp-3910	11	22	discussed	discuss	VERB
fnp-3910	11	23	,	,	PUNCT
fnp-3910	11	24	followed	follow	VERB
fnp-3910	11	25	by	by	ADP
fnp-3910	11	26	work	work	NOUN
fnp-3910	11	27	on	on	ADP
fnp-3910	11	28	how	how	SCONJ
fnp-3910	11	29	perivascular	perivascular	ADJ
fnp-3910	11	30	aβ	aβ	NOUN
fnp-3910	11	31	is	be	AUX
fnp-3910	11	32	potentially	potentially	ADV
fnp-3910	11	33	cleared	clear	VERB
fnp-3910	11	34	along	along	ADP
fnp-3910	11	35	the	the	DET
fnp-3910	11	36	cerebral	cerebral	ADJ
fnp-3910	11	37	vessels	vessel	NOUN
fnp-3910	11	38	in	in	ADP
fnp-3910	11	39	patients	patient	NOUN
fnp-3910	11	40	with	with	ADP
fnp-3910	11	41	cerebral	cerebral	ADJ
fnp-3910	11	42	amyloid	amyloid	NOUN
fnp-3910	11	43	angiopathy	angiopathy	NOUN
fnp-3910	11	44	.	.	PUNCT
fnp-3910	12	1	the	the	DET
fnp-3910	12	2	final	final	ADJ
fnp-3910	12	3	two	two	NUM
fnp-3910	12	4	papers	paper	NOUN
fnp-3910	12	5	focus	focus	VERB
fnp-3910	12	6	on	on	ADP
fnp-3910	12	7	the	the	DET
fnp-3910	12	8	contribution	contribution	NOUN
fnp-3910	12	9	of	of	ADP
fnp-3910	12	10	senescent	senescent	ADJ
fnp-3910	12	11	endothelial	endothelial	ADJ
fnp-3910	12	12	cells	cell	NOUN
fnp-3910	12	13	and	and	CCONJ
fnp-3910	12	14	pericytes	pericyte	NOUN
fnp-3910	12	15	.	.	PUNCT
fnp-3910	13	1	the	the	DET
fnp-3910	13	2	first	first	ADJ
fnp-3910	13	3	used	use	VERB
fnp-3910	13	4	a	a	DET
fnp-3910	13	5	model	model	NOUN
fnp-3910	13	6	of	of	ADP
fnp-3910	13	7	accelerated	accelerate	VERB
fnp-3910	13	8	senescence	senescence	NOUN
fnp-3910	13	9	(	(	PUNCT
fnp-3910	13	10	hutchinson	hutchinson	PROPN
fnp-3910	13	11	-	-	PUNCT
fnp-3910	13	12	gilford	gilford	PROPN
fnp-3910	13	13	progeria	progeria	NOUN
fnp-3910	13	14	syndrome	syndrome	NOUN
fnp-3910	13	15	;	;	PUNCT
fnp-3910	13	16	hgps	hgps	X
fnp-3910	13	17	)	)	PUNCT
fnp-3910	13	18	and	and	CCONJ
fnp-3910	13	19	shows	show	VERB
fnp-3910	13	20	the	the	DET
fnp-3910	13	21	translational	translational	ADJ
fnp-3910	13	22	potential	potential	NOUN
fnp-3910	13	23	of	of	ADP
fnp-3910	13	24	an	an	DET
fnp-3910	13	25	approach	approach	NOUN
fnp-3910	13	26	to	to	PART
fnp-3910	13	27	reduce	reduce	VERB
fnp-3910	13	28	telomere	telomere	NOUN
fnp-3910	13	29	shortening	shorten	VERB
fnp-3910	13	30	to	to	PART
fnp-3910	13	31	slow	slow	ADJ
fnp-3910	13	32	aging	aging	NOUN
fnp-3910	13	33	.	.	PUNCT
fnp-3910	14	1	the	the	DET
fnp-3910	14	2	final	final	ADJ
fnp-3910	14	3	paper	paper	NOUN
fnp-3910	14	4	demonstrates	demonstrate	VERB
fnp-3910	14	5	how	how	SCONJ
fnp-3910	14	6	capillary	capillary	ADJ
fnp-3910	14	7	pericytes	pericyte	NOUN
fnp-3910	14	8	contribute	contribute	VERB
fnp-3910	14	9	to	to	AUX
fnp-3910	14	10	basal	basal	VERB
fnp-3910	14	11	blood	blood	NOUN
fnp-3910	14	12	flow	flow	NOUN
fnp-3910	14	13	resistance	resistance	NOUN
fnp-3910	14	14	and	and	CCONJ
fnp-3910	14	15	slow	slow	ADJ
fnp-3910	14	16	modulation	modulation	NOUN
fnp-3910	14	17	of	of	ADP
fnp-3910	14	18	blood	blood	NOUN
fnp-3910	14	19	flow	flow	NOUN
fnp-3910	14	20	throughout	throughout	ADP
fnp-3910	14	21	the	the	DET
fnp-3910	14	22	brain	brain	NOUN
fnp-3910	14	23	.	.	PUNCT
fnp-3910	15	1	interestingly	interestingly	ADV
fnp-3910	15	2	,	,	PUNCT
fnp-3910	15	3	several	several	ADJ
fnp-3910	15	4	of	of	ADP
fnp-3910	15	5	the	the	DET
fnp-3910	15	6	papers	paper	NOUN
fnp-3910	15	7	identified	identify	VERB
fnp-3910	15	8	therapeutic	therapeutic	ADJ
fnp-3910	15	9	strategies	strategy	NOUN
fnp-3910	15	10	that	that	PRON
fnp-3910	15	11	could	could	AUX
fnp-3910	15	12	be	be	AUX
fnp-3910	15	13	potentially	potentially	ADV
fnp-3910	15	14	translated	translate	VERB
fnp-3910	15	15	into	into	ADP
fnp-3910	15	16	clinical	clinical	ADJ
fnp-3910	15	17	populations	population	NOUN
fnp-3910	15	18	.	.	PUNCT
fnp-3910	16	1	introduction	introduction	NOUN
fnp-3910	16	2	this	this	DET
fnp-3910	16	3	“	"	PUNCT
fnp-3910	16	4	neurovascular	neurovascular	ADJ
fnp-3910	16	5	disease	disease	NOUN
fnp-3910	16	6	:	:	PUNCT
fnp-3910	16	7	2022	2022	NUM
fnp-3910	16	8	update	update	NOUN
fnp-3910	16	9	”	"	PUNCT
fnp-3910	16	10	presents	present	VERB
fnp-3910	16	11	topics	topic	NOUN
fnp-3910	16	12	that	that	PRON
fnp-3910	16	13	were	be	AUX
fnp-3910	16	14	selected	select	VERB
fnp-3910	16	15	as	as	ADP
fnp-3910	16	16	the	the	DET
fnp-3910	16	17	top	top	ADJ
fnp-3910	16	18	10	10	NUM
fnp-3910	16	19	papers	paper	NOUN
fnp-3910	16	20	and	and	CCONJ
fnp-3910	16	21	discoveries	discovery	NOUN
fnp-3910	16	22	published	publish	VERB
fnp-3910	16	23	in	in	ADP
fnp-3910	16	24	the	the	DET
fnp-3910	16	25	field	field	NOUN
fnp-3910	16	26	of	of	ADP
fnp-3910	16	27	neurovascular	neurovascular	ADJ
fnp-3910	16	28	disorders	disorder	NOUN
fnp-3910	16	29	in	in	ADP
fnp-3910	16	30	2021	2021	NUM
fnp-3910	16	31	.	.	PUNCT
fnp-3910	17	1	these	these	DET
fnp-3910	17	2	papers	paper	NOUN
fnp-3910	17	3	were	be	AUX
fnp-3910	17	4	selected	select	VERB
fnp-3910	17	5	based	base	VERB
fnp-3910	17	6	on	on	ADP
fnp-3910	17	7	their	their	PRON
fnp-3910	17	8	broad	broad	ADJ
fnp-3910	17	9	appeal	appeal	NOUN
fnp-3910	17	10	,	,	PUNCT
fnp-3910	17	11	those	those	PRON
fnp-3910	17	12	with	with	ADP
fnp-3910	17	13	new	new	ADJ
fnp-3910	17	14	methods	method	NOUN
fnp-3910	17	15	or	or	CCONJ
fnp-3910	17	16	discoveries	discovery	NOUN
fnp-3910	17	17	,	,	PUNCT
fnp-3910	17	18	and	and	CCONJ
fnp-3910	17	19	those	those	PRON
fnp-3910	17	20	that	that	PRON
fnp-3910	17	21	have	have	VERB
fnp-3910	17	22	a	a	DET
fnp-3910	17	23	direct	direct	ADJ
fnp-3910	17	24	link	link	NOUN
fnp-3910	17	25	to	to	ADP
fnp-3910	17	26	neurovascular	neurovascular	ADJ
fnp-3910	17	27	inflammation	inflammation	NOUN
fnp-3910	17	28	,	,	PUNCT
fnp-3910	17	29	vascular	vascular	ADJ
fnp-3910	17	30	abnormalities	abnormality	NOUN
fnp-3910	17	31	and	and	CCONJ
fnp-3910	17	32	neuroimmunology	neuroimmunology	NOUN
fnp-3910	17	33	.	.	PUNCT
fnp-3910	18	1	it	it	PRON
fnp-3910	18	2	is	be	AUX
fnp-3910	18	3	important	important	ADJ
fnp-3910	18	4	to	to	PART
fnp-3910	18	5	note	note	VERB
fnp-3910	18	6	that	that	SCONJ
fnp-3910	18	7	these	these	DET
fnp-3910	18	8	top	top	ADJ
fnp-3910	18	9	ten	ten	NUM
fnp-3910	18	10	papers	paper	NOUN
fnp-3910	18	11	were	be	AUX
fnp-3910	18	12	subjectively	subjectively	ADV
fnp-3910	18	13	selected	select	VERB
fnp-3910	18	14	by	by	ADP
fnp-3910	18	15	many	many	ADJ
fnp-3910	18	16	individuals	individual	NOUN
fnp-3910	18	17	when	when	SCONJ
fnp-3910	18	18	queried	query	VERB
fnp-3910	18	19	regarding	regard	VERB
fnp-3910	18	20	what	what	PRON
fnp-3910	18	21	papers	paper	NOUN
fnp-3910	18	22	they	they	PRON
fnp-3910	18	23	felt	feel	VERB
fnp-3910	18	24	were	be	AUX
fnp-3910	18	25	most	most	ADV
fnp-3910	18	26	impactful	impactful	ADJ
fnp-3910	18	27	in	in	ADP
fnp-3910	18	28	2021	2021	NUM
fnp-3910	18	29	(	(	PUNCT
fnp-3910	18	30	individual	individual	ADJ
fnp-3910	18	31	contributors	contributor	NOUN
fnp-3910	18	32	are	be	AUX
fnp-3910	18	33	listed	list	VERB
fnp-3910	18	34	in	in	ADP
fnp-3910	18	35	the	the	DET
fnp-3910	18	36	acknowledgement	acknowledgement	NOUN
fnp-3910	18	37	section	section	NOUN
fnp-3910	18	38	)	)	PUNCT
fnp-3910	18	39	.	.	PUNCT
fnp-3910	19	1	thus	thus	ADV
fnp-3910	19	2	,	,	PUNCT
fnp-3910	19	3	there	there	PRON
fnp-3910	19	4	is	be	VERB
fnp-3910	19	5	certainly	certainly	ADV
fnp-3910	19	6	considerable	considerable	ADJ
fnp-3910	19	7	“	"	PUNCT
fnp-3910	19	8	selection	selection	NOUN
fnp-3910	19	9	bias	bias	NOUN
fnp-3910	19	10	”	"	PUNCT
fnp-3910	19	11	.	.	PUNCT
fnp-3910	20	1	these	these	DET
fnp-3910	20	2	papers	paper	NOUN
fnp-3910	20	3	were	be	AUX
fnp-3910	20	4	chosen	choose	VERB
fnp-3910	20	5	by	by	ADP
fnp-3910	20	6	a	a	DET
fnp-3910	20	7	large	large	ADJ
fnp-3910	20	8	group	group	NOUN
fnp-3910	20	9	of	of	ADP
fnp-3910	20	10	neurosurgery	neurosurgery	NOUN
fnp-3910	20	11	and	and	CCONJ
fnp-3910	20	12	neurology	neurology	NOUN
fnp-3910	20	13	faculty	faculty	NOUN
fnp-3910	20	14	,	,	PUNCT
fnp-3910	20	15	and	and	CCONJ
fnp-3910	20	16	are	be	AUX
fnp-3910	20	17	not	not	PART
fnp-3910	20	18	ranked	rank	VERB
fnp-3910	20	19	in	in	ADP
fnp-3910	20	20	any	any	DET
fnp-3910	20	21	specific	specific	ADJ
fnp-3910	20	22	order	order	NOUN
fnp-3910	20	23	or	or	CCONJ
fnp-3910	20	24	by	by	ADP
fnp-3910	20	25	number	number	NOUN
fnp-3910	20	26	of	of	ADP
fnp-3910	20	27	citations	citation	NOUN
fnp-3910	20	28	.	.	PUNCT
fnp-3910	21	1	overall	overall	ADV
fnp-3910	21	2	,	,	PUNCT
fnp-3910	21	3	the	the	DET
fnp-3910	21	4	theme	theme	NOUN
fnp-3910	21	5	of	of	ADP
fnp-3910	21	6	the	the	DET
fnp-3910	21	7	selected	select	VERB
fnp-3910	21	8	papers	paper	NOUN
fnp-3910	21	9	reflects	reflect	VERB
fnp-3910	21	10	our	our	PRON
fnp-3910	21	11	growing	grow	VERB
fnp-3910	21	12	understanding	understanding	NOUN
fnp-3910	21	13	of	of	ADP
fnp-3910	21	14	how	how	SCONJ
fnp-3910	21	15	immunological	immunological	ADJ
fnp-3910	21	16	events	event	NOUN
fnp-3910	21	17	,	,	PUNCT
fnp-3910	21	18	both	both	PRON
fnp-3910	21	19	in	in	ADP
fnp-3910	21	20	the	the	DET
fnp-3910	21	21	brain	brain	NOUN
fnp-3910	21	22	and	and	CCONJ
fnp-3910	21	23	in	in	ADP
fnp-3910	21	24	the	the	DET
fnp-3910	21	25	periphery	periphery	NOUN
fnp-3910	21	26	,	,	PUNCT
fnp-3910	21	27	alter	alter	VERB
fnp-3910	21	28	the	the	DET
fnp-3910	21	29	response	response	NOUN
fnp-3910	21	30	to	to	PART
fnp-3910	21	31	vascular	vascular	VERB
fnp-3910	21	32	and	and	CCONJ
fnp-3910	21	33	degenerative	degenerative	ADJ
fnp-3910	21	34	diseases	disease	NOUN
fnp-3910	21	35	.	.	PUNCT
fnp-3910	22	1	the	the	DET
fnp-3910	22	2	field	field	NOUN
fnp-3910	22	3	of	of	ADP
fnp-3910	22	4	neuroimmunology	neuroimmunology	NOUN
fnp-3910	22	5	has	have	AUX
fnp-3910	22	6	seen	see	VERB
fnp-3910	22	7	tremendous	tremendous	ADJ
fnp-3910	22	8	growth	growth	NOUN
fnp-3910	22	9	over	over	ADP
fnp-3910	22	10	the	the	DET
fnp-3910	22	11	past	past	ADJ
fnp-3910	22	12	decade	decade	NOUN
fnp-3910	22	13	,	,	PUNCT
fnp-3910	22	14	and	and	CCONJ
fnp-3910	22	15	this	this	PRON
fnp-3910	22	16	is	be	AUX
fnp-3910	22	17	reflected	reflect	VERB
fnp-3910	22	18	in	in	ADP
fnp-3910	22	19	the	the	DET
fnp-3910	22	20	papers	paper	NOUN
fnp-3910	22	21	selected	select	VERB
fnp-3910	22	22	.	.	PUNCT
fnp-3910	23	1	we	we	PRON
fnp-3910	23	2	apologize	apologize	VERB
fnp-3910	23	3	to	to	ADP
fnp-3910	23	4	all	all	DET
fnp-3910	23	5	the	the	DET
fnp-3910	23	6	authors	author	NOUN
fnp-3910	23	7	we	we	PRON
fnp-3910	23	8	could	could	AUX
fnp-3910	23	9	not	not	PART
fnp-3910	23	10	highlight	highlight	VERB
fnp-3910	23	11	due	due	ADJ
fnp-3910	23	12	to	to	ADP
fnp-3910	23	13	space	space	NOUN
fnp-3910	23	14	limitations	limitation	NOUN
fnp-3910	23	15	.	.	PUNCT
fnp-3910	24	1	topic	topic	NOUN
fnp-3910	24	2	1	1	NUM
fnp-3910	24	3	:	:	PUNCT
fnp-3910	24	4	selective	selective	ADJ
fnp-3910	24	5	endothelial	endothelial	ADJ
fnp-3910	24	6	hyperactivation	hyperactivation	NOUN
fnp-3910	24	7	of	of	ADP
fnp-3910	24	8	oncogenic	oncogenic	ADJ
fnp-3910	24	9	kras	kra	NOUN
fnp-3910	24	10	induces	induce	VERB
fnp-3910	24	11	brain	brain	NOUN
fnp-3910	24	12	arteriovenous	arteriovenous	ADJ
fnp-3910	24	13	malformations	malformation	NOUN
fnp-3910	24	14	in	in	ADP
fnp-3910	24	15	mice	mouse	NOUN
fnp-3910	24	16	brain	brain	NOUN
fnp-3910	24	17	arteriovenous	arteriovenous	ADJ
fnp-3910	24	18	malformations	malformation	NOUN
fnp-3910	24	19	(	(	PUNCT
fnp-3910	24	20	bavms	bavms	NOUN
fnp-3910	24	21	)	)	PUNCT
fnp-3910	24	22	are	be	AUX
fnp-3910	24	23	a	a	DET
fnp-3910	24	24	challenging	challenge	VERB
fnp-3910	24	25	cerebrovascular	cerebrovascular	ADJ
fnp-3910	24	26	disease	disease	NOUN
fnp-3910	24	27	,	,	PUNCT
fnp-3910	24	28	characterized	characterize	VERB
fnp-3910	24	29	by	by	ADP
fnp-3910	24	30	tangled	tangle	VERB
fnp-3910	24	31	/	/	SYM
fnp-3910	24	32	enlarged	enlarge	VERB
fnp-3910	24	33	vessels	vessel	NOUN
fnp-3910	24	34	occurred	occur	VERB
fnp-3910	24	35	by	by	ADP
fnp-3910	24	36	direct	direct	ADJ
fnp-3910	24	37	connections	connection	NOUN
fnp-3910	24	38	between	between	ADP
fnp-3910	24	39	arteries	artery	NOUN
fnp-3910	24	40	and	and	CCONJ
fnp-3910	24	41	veins	vein	NOUN
fnp-3910	24	42	without	without	ADP
fnp-3910	24	43	intervening	intervene	VERB
fnp-3910	24	44	capillary	capillary	ADJ
fnp-3910	24	45	bed	bed	NOUN
fnp-3910	24	46	.	.	PUNCT
fnp-3910	25	1	bavms	bavms	PROPN
fnp-3910	25	2	are	be	AUX
fnp-3910	25	3	a	a	DET
fnp-3910	25	4	major	major	ADJ
fnp-3910	25	5	cause	cause	NOUN
fnp-3910	25	6	of	of	ADP
fnp-3910	25	7	the	the	DET
fnp-3910	25	8	most	most	ADV
fnp-3910	25	9	debilitating	debilitate	VERB
fnp-3910	25	10	spontaneous	spontaneous	ADJ
fnp-3910	25	11	intracerebral	intracerebral	ADJ
fnp-3910	25	12	hemorrhage	hemorrhage	NOUN
fnp-3910	25	13	in	in	ADP
fnp-3910	25	14	children	child	NOUN
fnp-3910	25	15	and	and	CCONJ
fnp-3910	25	16	young	young	ADJ
fnp-3910	25	17	adults	adult	NOUN
fnp-3910	25	18	.	.	PUNCT
fnp-3910	26	1	however	however	ADV
fnp-3910	26	2	,	,	PUNCT
fnp-3910	26	3	the	the	DET
fnp-3910	26	4	pathogenesis	pathogenesis	NOUN
fnp-3910	26	5	of	of	ADP
fnp-3910	26	6	the	the	DET
fnp-3910	26	7	disease	disease	NOUN
fnp-3910	26	8	is	be	AUX
fnp-3910	26	9	largely	largely	ADV
fnp-3910	26	10	unknown	unknown	ADJ
fnp-3910	26	11	,	,	PUNCT
fnp-3910	26	12	and	and	CCONJ
fnp-3910	26	13	the	the	DET
fnp-3910	26	14	treatment	treatment	NOUN
fnp-3910	26	15	options	option	NOUN
fnp-3910	26	16	for	for	ADP
fnp-3910	26	17	bavm	bavm	PROPN
fnp-3910	26	18	patients	patient	NOUN
fnp-3910	26	19	are	be	AUX
fnp-3910	26	20	severely	severely	ADV
fnp-3910	26	21	limited	limit	VERB
fnp-3910	26	22	mostly	mostly	ADV
fnp-3910	26	23	relying	rely	VERB
fnp-3910	26	24	on	on	ADP
fnp-3910	26	25	risky	risky	ADJ
fnp-3910	26	26	surgical	surgical	ADJ
fnp-3910	26	27	methods	method	NOUN
fnp-3910	26	28	.	.	PUNCT
fnp-3910	27	1	recently	recently	ADV
fnp-3910	27	2	,	,	PUNCT
fnp-3910	27	3	a	a	DET
fnp-3910	27	4	clinical	clinical	ADJ
fnp-3910	27	5	study	study	NOUN
fnp-3910	27	6	has	have	AUX
fnp-3910	27	7	reported	report	VERB
fnp-3910	27	8	that	that	SCONJ
fnp-3910	27	9	somatic	somatic	ADJ
fnp-3910	27	10	activating	activate	VERB
fnp-3910	27	11	kras	kra	NOUN
fnp-3910	27	12	mutations	mutation	NOUN
fnp-3910	27	13	were	be	AUX
fnp-3910	27	14	detected	detect	VERB
fnp-3910	27	15	in	in	ADP
fnp-3910	27	16	the	the	DET
fnp-3910	27	17	endothelium	endothelium	NOUN
fnp-3910	27	18	of	of	ADP
fnp-3910	27	19	~60	~60	DET
fnp-3910	27	20	%	%	NOUN
fnp-3910	27	21	of	of	ADP
fnp-3910	27	22	human	human	ADJ
fnp-3910	27	23	sporadic	sporadic	ADJ
fnp-3910	27	24	bavms	bavms	NOUN
fnp-3910	27	25	(	(	PUNCT
fnp-3910	27	26	1	1	NUM
fnp-3910	27	27	)	)	PUNCT
fnp-3910	27	28	.	.	PUNCT
fnp-3910	28	1	in	in	ADP
fnp-3910	28	2	addition	addition	NOUN
fnp-3910	28	3	,	,	PUNCT
fnp-3910	28	4	mosaic	mosaic	ADJ
fnp-3910	28	5	variants	variant	NOUN
fnp-3910	28	6	have	have	AUX
fnp-3910	28	7	also	also	ADV
fnp-3910	28	8	been	be	AUX
fnp-3910	28	9	found	find	VERB
fnp-3910	28	10	in	in	ADP
fnp-3910	28	11	the	the	DET
fnp-3910	28	12	braf	braf	NOUN
fnp-3910	28	13	and	and	CCONJ
fnp-3910	28	14	map2k1	map2k1	PROPN
fnp-3910	28	15	/	/	SYM
fnp-3910	28	16	mek	mek	PROPN
fnp-3910	28	17	in	in	ADP
fnp-3910	28	18	intracranial	intracranial	ADJ
fnp-3910	28	19	or	or	CCONJ
fnp-3910	28	20	extracranial	extracranial	ADJ
fnp-3910	28	21	avms	avms	NOUN
fnp-3910	28	22	,	,	PUNCT
fnp-3910	28	23	especially	especially	ADV
fnp-3910	28	24	in	in	ADP
fnp-3910	28	25	high	high	ADJ
fnp-3910	28	26	-	-	PUNCT
fnp-3910	28	27	flow	flow	NOUN
fnp-3910	28	28	vascular	vascular	ADJ
fnp-3910	28	29	malformations	malformation	NOUN
fnp-3910	28	30	(	(	PUNCT
fnp-3910	28	31	2	2	NUM
fnp-3910	28	32	)	)	PUNCT
fnp-3910	28	33	.	.	PUNCT
fnp-3910	29	1	these	these	DET
fnp-3910	29	2	observations	observation	NOUN
fnp-3910	29	3	suggest	suggest	VERB
fnp-3910	29	4	the	the	DET
fnp-3910	29	5	critical	critical	ADJ
fnp-3910	29	6	role	role	NOUN
fnp-3910	29	7	of	of	ADP
fnp-3910	29	8	kras	kra	NOUN
fnp-3910	29	9	signaling	signal	VERB
fnp-3910	29	10	,	,	PUNCT
fnp-3910	29	11	especially	especially	ADV
fnp-3910	29	12	raf	raf	PROPN
fnp-3910	29	13	/	/	SYM
fnp-3910	29	14	mek	mek	PROPN
fnp-3910	29	15	/	/	SYM
fnp-3910	29	16	erk	erk	PROPN
fnp-3910	29	17	kinase	kinase	PROPN
fnp-3910	29	18	cascade	cascade	NOUN
fnp-3910	29	19	in	in	ADP
fnp-3910	29	20	avm	avm	PROPN
fnp-3910	29	21	pathogenesis	pathogenesis	PROPN
fnp-3910	29	22	.	.	PUNCT
fnp-3910	30	1	based	base	VERB
fnp-3910	30	2	on	on	ADP
fnp-3910	30	3	this	this	DET
fnp-3910	30	4	evidence	evidence	NOUN
fnp-3910	30	5	,	,	PUNCT
fnp-3910	30	6	the	the	DET
fnp-3910	30	7	authors	author	NOUN
fnp-3910	30	8	tested	test	VERB
fnp-3910	30	9	the	the	DET
fnp-3910	30	10	role	role	NOUN
fnp-3910	30	11	of	of	ADP
fnp-3910	30	12	kras	kras	PROPN
fnp-3910	30	13	mutation	mutation	NOUN
fnp-3910	30	14	in	in	ADP
fnp-3910	30	15	bavm	bavm	PROPN
fnp-3910	30	16	development	development	PROPN
fnp-3910	30	17	using	use	VERB
fnp-3910	30	18	an	an	DET
fnp-3910	30	19	adeno	adeno	NOUN
fnp-3910	30	20	-	-	PUNCT
fnp-3910	30	21	associated	associate	VERB
fnp-3910	30	22	virus	virus	NOUN
fnp-3910	30	23	(	(	PUNCT
fnp-3910	30	24	aav)-br1	aav)-br1	AUX
fnp-3910	30	25	specifically	specifically	ADV
fnp-3910	30	26	targeting	target	VERB
fnp-3910	30	27	brain	brain	NOUN
fnp-3910	30	28	vascular	vascular	ADJ
fnp-3910	30	29	endothelial	endothelial	ADJ
fnp-3910	30	30	cells	cell	NOUN
fnp-3910	30	31	.	.	PUNCT
fnp-3910	31	1	strikingly	strikingly	ADV
fnp-3910	31	2	,	,	PUNCT
fnp-3910	31	3	the	the	DET
fnp-3910	31	4	systemic	systemic	ADJ
fnp-3910	31	5	administration	administration	NOUN
fnp-3910	31	6	of	of	ADP
fnp-3910	31	7	aav	aav	PROPN
fnp-3910	31	8	-	-	PUNCT
fnp-3910	31	9	br1	br1	PROPN
fnp-3910	31	10	encoding	encode	VERB
fnp-3910	31	11	human	human	PROPN
fnp-3910	31	12	krasg12v	krasg12v	PROPN
fnp-3910	31	13	gene	gene	NOUN
fnp-3910	31	14	(	(	PUNCT
fnp-3910	31	15	aav	aav	PROPN
fnp-3910	31	16	-	-	PUNCT
fnp-3910	31	17	br1	br1	PROPN
fnp-3910	31	18	-	-	PUNCT
fnp-3910	31	19	krasg12v	krasg12v	NOUN
fnp-3910	31	20	)	)	PUNCT
fnp-3910	31	21	induced	induce	VERB
fnp-3910	31	22	vascular	vascular	ADJ
fnp-3910	31	23	malformations	malformation	NOUN
fnp-3910	31	24	in	in	ADP
fnp-3910	31	25	the	the	DET
fnp-3910	31	26	mouse	mouse	NOUN
fnp-3910	31	27	brains	brain	NOUN
fnp-3910	31	28	that	that	PRON
fnp-3910	31	29	recapitulates	recapitulate	VERB
fnp-3910	31	30	salient	salient	NOUN
fnp-3910	31	31	features	feature	NOUN
fnp-3910	31	32	of	of	ADP
fnp-3910	31	33	human	human	ADJ
fnp-3910	31	34	bavms	bavms	NOUN
fnp-3910	31	35	including	include	VERB
fnp-3910	31	36	the	the	DET
fnp-3910	31	37	tangled	tangle	VERB
fnp-3910	31	38	nidus	nidus	NOUN
fnp-3910	31	39	connected	connect	VERB
fnp-3910	31	40	with	with	ADP
fnp-3910	31	41	feeding	feed	VERB
fnp-3910	31	42	arteries	artery	NOUN
fnp-3910	31	43	and	and	CCONJ
fnp-3910	31	44	draining	drain	VERB
fnp-3910	31	45	veins	vein	NOUN
fnp-3910	31	46	,	,	PUNCT
fnp-3910	31	47	multi	multi	ADJ
fnp-3910	31	48	-	-	ADJ
fnp-3910	31	49	focal	focal	ADJ
fnp-3910	31	50	spontaneous	spontaneous	ADJ
fnp-3910	31	51	intracerebral	intracerebral	ADJ
fnp-3910	31	52	hemorrhages	hemorrhage	NOUN
fnp-3910	31	53	,	,	PUNCT
fnp-3910	31	54	ambiguous	ambiguous	ADJ
fnp-3910	31	55	arterial	arterial	NOUN
fnp-3910	31	56	/	/	SYM
fnp-3910	31	57	venous	venous	ADJ
fnp-3910	31	58	identity	identity	NOUN
fnp-3910	31	59	and	and	CCONJ
fnp-3910	31	60	irregular	irregular	ADJ
fnp-3910	31	61	/	/	SYM
fnp-3910	31	62	incomplete	incomplete	ADJ
fnp-3910	31	63	mural	mural	ADJ
fnp-3910	31	64	cell	cell	NOUN
fnp-3910	31	65	coverage	coverage	NOUN
fnp-3910	31	66	,	,	PUNCT
fnp-3910	31	67	and	and	CCONJ
fnp-3910	31	68	enhanced	enhance	VERB
fnp-3910	31	69	proliferating	proliferate	VERB
fnp-3910	31	70	endothelial	endothelial	ADJ
fnp-3910	31	71	cells	cell	NOUN
fnp-3910	31	72	and	and	CCONJ
fnp-3910	31	73	angiogenic	angiogenic	ADJ
fnp-3910	31	74	factors	factor	NOUN
fnp-3910	31	75	.	.	PUNCT
fnp-3910	32	1	the	the	DET
fnp-3910	32	2	accumulation	accumulation	NOUN
fnp-3910	32	3	of	of	ADP
fnp-3910	32	4	activated	activate	VERB
fnp-3910	32	5	microglia	microglia	NOUN
fnp-3910	32	6	/	/	SYM
fnp-3910	32	7	macrophages	macrophage	NOUN
fnp-3910	32	8	,	,	PUNCT
fnp-3910	32	9	enhanced	enhance	VERB
fnp-3910	32	10	inflammatory	inflammatory	ADJ
fnp-3910	32	11	response	response	NOUN
fnp-3910	32	12	,	,	PUNCT
fnp-3910	32	13	and	and	CCONJ
fnp-3910	32	14	neuronal	neuronal	ADJ
fnp-3910	32	15	death	death	NOUN
fnp-3910	32	16	were	be	AUX
fnp-3910	32	17	observed	observe	VERB
fnp-3910	32	18	around	around	ADP
fnp-3910	32	19	bavms	bavms	NOUN
fnp-3910	32	20	,	,	PUNCT
fnp-3910	32	21	and	and	CCONJ
fnp-3910	32	22	mice	mouse	NOUN
fnp-3910	32	23	with	with	ADP
fnp-3910	32	24	bavm	bavm	PROPN
fnp-3910	32	25	showed	show	VERB
fnp-3910	32	26	impaired	impaired	ADJ
fnp-3910	32	27	behavioral	behavioral	ADJ
fnp-3910	32	28	functions	function	NOUN
fnp-3910	32	29	.	.	PUNCT
fnp-3910	33	1	the	the	DET
fnp-3910	33	2	study	study	NOUN
fnp-3910	33	3	found	find	VERB
fnp-3910	33	4	the	the	DET
fnp-3910	33	5	erk	erk	PROPN
fnp-3910	33	6	activation	activation	NOUN
fnp-3910	33	7	,	,	PUNCT
fnp-3910	33	8	but	but	CCONJ
fnp-3910	33	9	not	not	PART
fnp-3910	33	10	pakt	pakt	NOUN
fnp-3910	33	11	and	and	CCONJ
fnp-3910	33	12	p38	p38	NOUN
fnp-3910	33	13	,	,	PUNCT
fnp-3910	33	14	in	in	ADP
fnp-3910	33	15	the	the	DET
fnp-3910	33	16	bavms	bavms	NOUN
fnp-3910	33	17	suggesting	suggest	VERB
fnp-3910	33	18	that	that	SCONJ
fnp-3910	33	19	mek	mek	PROPN
fnp-3910	33	20	/	/	SYM
fnp-3910	33	21	erk	erk	PROPN
fnp-3910	33	22	signaling	signal	VERB
fnp-3910	33	23	is	be	AUX
fnp-3910	33	24	the	the	DET
fnp-3910	33	25	key	key	ADJ
fnp-3910	33	26	mediator	mediator	NOUN
fnp-3910	33	27	for	for	ADP
fnp-3910	33	28	the	the	DET
fnp-3910	33	29	mutant	mutant	ADJ
fnp-3910	33	30	kras	kras	PROPN
fnp-3910	33	31	-	-	PUNCT
fnp-3910	33	32	induced	induce	VERB
fnp-3910	33	33	bavm	bavm	NOUN
fnp-3910	33	34	development	development	NOUN
fnp-3910	33	35	,	,	PUNCT
fnp-3910	33	36	and	and	CCONJ
fnp-3910	33	37	finally	finally	ADV
fnp-3910	33	38	revealed	reveal	VERB
fnp-3910	33	39	that	that	SCONJ
fnp-3910	33	40	trametinib	trametinib	NOUN
fnp-3910	33	41	(	(	PUNCT
fnp-3910	33	42	an	an	DET
fnp-3910	33	43	fda	fda	PROPN
fnp-3910	33	44	-	-	PUNCT
fnp-3910	33	45	approved	approve	VERB
fnp-3910	33	46	mek	mek	PROPN
fnp-3910	33	47	inhibitor	inhibitor	NOUN
fnp-3910	33	48	for	for	ADP
fnp-3910	33	49	cancer	cancer	NOUN
fnp-3910	33	50	)	)	PUNCT
fnp-3910	33	51	attenuates	attenuate	VERB
fnp-3910	33	52	the	the	DET
fnp-3910	33	53	growth	growth	NOUN
fnp-3910	33	54	of	of	ADP
fnp-3910	33	55	krasg12v	krasg12v	NOUN
fnp-3910	33	56	-	-	PUNCT
fnp-3910	33	57	induced	induce	VERB
fnp-3910	33	58	bavms	bavms	NOUN
fnp-3910	33	59	(	(	PUNCT
fnp-3910	33	60	figure	figure	NOUN
fnp-3910	33	61	1	1	NUM
fnp-3910	33	62	)	)	PUNCT
fnp-3910	33	63	.	.	PUNCT
fnp-3910	34	1	the	the	DET
fnp-3910	34	2	novel	novel	ADJ
fnp-3910	34	3	approach	approach	NOUN
fnp-3910	34	4	by	by	ADP
fnp-3910	34	5	park	park	NOUN
fnp-3910	34	6	et	et	PROPN
fnp-3910	34	7	al	al	PROPN
fnp-3910	34	8	.	.	PROPN
fnp-3910	35	1	(	(	PUNCT
fnp-3910	35	2	3	3	X
fnp-3910	35	3	)	)	PUNCT
fnp-3910	35	4	clearly	clearly	ADV
fnp-3910	35	5	confirmed	confirm	VERB
fnp-3910	35	6	the	the	DET
fnp-3910	35	7	causative	causative	ADJ
fnp-3910	35	8	role	role	NOUN
fnp-3910	35	9	of	of	ADP
fnp-3910	35	10	kras	kras	PROPN
fnp-3910	35	11	mutations	mutation	NOUN
fnp-3910	35	12	in	in	ADP
fnp-3910	35	13	bavm	bavm	PROPN
fnp-3910	35	14	development	development	NOUN
fnp-3910	35	15	,	,	PUNCT
fnp-3910	35	16	and	and	CCONJ
fnp-3910	35	17	generated	generate	VERB
fnp-3910	35	18	a	a	DET
fnp-3910	35	19	novel	novel	NOUN
fnp-3910	35	20	/	/	SYM
fnp-3910	35	21	clinically	clinically	ADV
fnp-3910	35	22	-	-	PUNCT
fnp-3910	35	23	relevant	relevant	ADJ
fnp-3910	35	24	mouse	mouse	NOUN
fnp-3910	35	25	model	model	NOUN
fnp-3910	35	26	of	of	ADP
fnp-3910	35	27	bavms	bavms	NOUN
fnp-3910	35	28	that	that	PRON
fnp-3910	35	29	will	will	AUX
fnp-3910	35	30	be	be	AUX
fnp-3910	35	31	useful	useful	ADJ
fnp-3910	35	32	to	to	PART
fnp-3910	35	33	define	define	VERB
fnp-3910	35	34	the	the	DET
fnp-3910	35	35	underlying	underlie	VERB
fnp-3910	35	36	pathomechanism	pathomechanism	NOUN
fnp-3910	35	37	in	in	ADP
fnp-3910	35	38	bavms	bavms	NOUN
fnp-3910	35	39	.	.	PUNCT
fnp-3910	36	1	this	this	PRON
fnp-3910	36	2	is	be	AUX
fnp-3910	36	3	the	the	DET
fnp-3910	36	4	first	first	ADJ
fnp-3910	36	5	preclinical	preclinical	ADJ
fnp-3910	36	6	study	study	NOUN
fnp-3910	36	7	showing	show	VERB
fnp-3910	36	8	the	the	DET
fnp-3910	36	9	efficacy	efficacy	NOUN
fnp-3910	36	10	of	of	ADP
fnp-3910	36	11	pharmacological	pharmacological	ADJ
fnp-3910	36	12	intervention	intervention	NOUN
fnp-3910	36	13	in	in	ADP
fnp-3910	36	14	sporadic	sporadic	ADJ
fnp-3910	36	15	bavms	bavms	NOUN
fnp-3910	36	16	associated	associate	VERB
fnp-3910	36	17	with	with	ADP
fnp-3910	36	18	kras	kras	PROPN
fnp-3910	36	19	mutation	mutation	NOUN
fnp-3910	36	20	providing	provide	VERB
fnp-3910	36	21	a	a	DET
fnp-3910	36	22	potential	potential	ADJ
fnp-3910	36	23	therapeutic	therapeutic	ADJ
fnp-3910	36	24	strategy	strategy	NOUN
fnp-3910	36	25	for	for	ADP
fnp-3910	36	26	bavm	bavm	PROPN
fnp-3910	36	27	patients	patient	NOUN
fnp-3910	36	28	by	by	ADP
fnp-3910	36	29	repurposing	repurpose	VERB
fnp-3910	36	30	a	a	DET
fnp-3910	36	31	cancer	cancer	NOUN
fnp-3910	36	32	drug	drug	NOUN
fnp-3910	36	33	.	.	PUNCT
fnp-3910	37	1	figure	figure	NOUN
fnp-3910	37	2	1	1	NUM
fnp-3910	37	3	.	.	PUNCT
fnp-3910	38	1	the	the	DET
fnp-3910	38	2	characteristics	characteristic	NOUN
fnp-3910	38	3	of	of	ADP
fnp-3910	38	4	mouse	mouse	NOUN
fnp-3910	38	5	bavms	bavms	NOUN
fnp-3910	38	6	induced	induce	VERB
fnp-3910	38	7	by	by	ADP
fnp-3910	38	8	brain	brain	NOUN
fnp-3910	38	9	endothelial	endothelial	ADJ
fnp-3910	38	10	krasg12v	krasg12v	NOUN
fnp-3910	38	11	overexpression	overexpression	NOUN
fnp-3910	38	12	.	.	PUNCT
fnp-3910	39	1	systemic	systemic	ADJ
fnp-3910	39	2	injection	injection	NOUN
fnp-3910	39	3	of	of	ADP
fnp-3910	39	4	aav	aav	PROPN
fnp-3910	39	5	-	-	PUNCT
fnp-3910	39	6	br1	br1	PROPN
fnp-3910	39	7	carrying	carry	VERB
fnp-3910	39	8	krasg12v	krasg12v	PROPN
fnp-3910	39	9	(	(	PUNCT
fnp-3910	39	10	aav	aav	PROPN
fnp-3910	39	11	-	-	PUNCT
fnp-3910	39	12	br1	br1	PROPN
fnp-3910	39	13	-	-	PUNCT
fnp-3910	39	14	krasg12v)-induced	krasg12v)-induce	VERB
fnp-3910	39	15	abnormal	abnormal	ADJ
fnp-3910	39	16	vasculatures	vasculature	NOUN
fnp-3910	39	17	that	that	PRON
fnp-3910	39	18	recapitulate	recapitulate	VERB
fnp-3910	39	19	the	the	DET
fnp-3910	39	20	salient	salient	NOUN
fnp-3910	39	21	features	feature	NOUN
fnp-3910	39	22	of	of	ADP
fnp-3910	39	23	human	human	ADJ
fnp-3910	39	24	bavms	bavms	NOUN
fnp-3910	39	25	including	include	VERB
fnp-3910	39	26	tangled	tangle	VERB
fnp-3910	39	27	nidus	nidus	PROPN
fnp-3910	39	28	,	,	PUNCT
fnp-3910	39	29	irregular	irregular	ADJ
fnp-3910	39	30	mural	mural	ADJ
fnp-3910	39	31	cell	cell	NOUN
fnp-3910	39	32	coverages	coverage	NOUN
fnp-3910	39	33	,	,	PUNCT
fnp-3910	39	34	and	and	CCONJ
fnp-3910	39	35	spontaneous	spontaneous	ADJ
fnp-3910	39	36	hemorrhages	hemorrhage	NOUN
fnp-3910	39	37	.	.	PUNCT
fnp-3910	40	1	enhanced	enhance	VERB
fnp-3910	40	2	endogenous	endogenous	ADJ
fnp-3910	40	3	vascular	vascular	ADJ
fnp-3910	40	4	endothelial	endothelial	NOUN
fnp-3910	40	5	growth	growth	NOUN
fnp-3910	40	6	factor	factor	NOUN
fnp-3910	40	7	(	(	PUNCT
fnp-3910	40	8	vegf	vegf	NOUN
fnp-3910	40	9	)	)	PUNCT
fnp-3910	40	10	signaling	signal	VERB
fnp-3910	40	11	and	and	CCONJ
fnp-3910	40	12	endothelial	endothelial	NOUN
fnp-3910	40	13	cell	cell	NOUN
fnp-3910	40	14	proliferation	proliferation	NOUN
fnp-3910	40	15	were	be	AUX
fnp-3910	40	16	observed	observe	VERB
fnp-3910	40	17	in	in	ADP
fnp-3910	40	18	the	the	DET
fnp-3910	40	19	bavms	bavms	NOUN
fnp-3910	40	20	.	.	PUNCT
fnp-3910	41	1	accumulating	accumulate	VERB
fnp-3910	41	2	activated	activate	VERB
fnp-3910	41	3	microglia	microglia	NOUN
fnp-3910	41	4	were	be	AUX
fnp-3910	41	5	seen	see	VERB
fnp-3910	41	6	around	around	ADP
fnp-3910	41	7	bavms	bavms	NOUN
fnp-3910	41	8	and	and	CCONJ
fnp-3910	41	9	accompanied	accompany	VERB
fnp-3910	41	10	with	with	ADP
fnp-3910	41	11	increased	increase	VERB
fnp-3910	41	12	expression	expression	NOUN
fnp-3910	41	13	of	of	ADP
fnp-3910	41	14	inflammatory	inflammatory	ADJ
fnp-3910	41	15	factors	factor	NOUN
fnp-3910	41	16	(	(	PUNCT
fnp-3910	41	17	e.g.	e.g.	ADV
fnp-3910	41	18	,	,	PUNCT
fnp-3910	41	19	cytokines	cytokine	NOUN
fnp-3910	41	20	,	,	PUNCT
fnp-3910	41	21	matrix	matrix	NOUN
fnp-3910	41	22	metalloproteinases	metalloproteinase	NOUN
fnp-3910	41	23	)	)	PUNCT
fnp-3910	41	24	and	and	CCONJ
fnp-3910	41	25	apoptotic	apoptotic	ADJ
fnp-3910	41	26	neurons	neuron	NOUN
fnp-3910	41	27	.	.	PUNCT
fnp-3910	42	1	mice	mouse	NOUN
fnp-3910	42	2	with	with	ADP
fnp-3910	42	3	bavm	bavm	PROPN
fnp-3910	42	4	showed	show	VERB
fnp-3910	42	5	significantly	significantly	ADV
fnp-3910	42	6	impaired	impair	VERB
fnp-3910	42	7	behavioral	behavioral	ADJ
fnp-3910	42	8	function	function	NOUN
fnp-3910	42	9	.	.	PUNCT
fnp-3910	43	1	prolonged	prolong	VERB
fnp-3910	43	2	treatment	treatment	NOUN
fnp-3910	43	3	with	with	ADP
fnp-3910	43	4	trametinib	trametinib	NOUN
fnp-3910	43	5	,	,	PUNCT
fnp-3910	43	6	an	an	DET
fnp-3910	43	7	fda	fda	PROPN
fnp-3910	43	8	-	-	PUNCT
fnp-3910	43	9	approved	approve	VERB
fnp-3910	43	10	mek	mek	PROPN
fnp-3910	43	11	inhibitor	inhibitor	NOUN
fnp-3910	43	12	(	(	PUNCT
fnp-3910	43	13	for	for	ADP
fnp-3910	43	14	six	six	NUM
fnp-3910	43	15	weeks	week	NOUN
fnp-3910	43	16	from	from	ADP
fnp-3910	43	17	one	one	NUM
fnp-3910	43	18	day	day	NOUN
fnp-3910	43	19	after	after	SCONJ
fnp-3910	43	20	the	the	DET
fnp-3910	43	21	aav	aav	PROPN
fnp-3910	43	22	-	-	PUNCT
fnp-3910	43	23	br1	br1	PROPN
fnp-3910	43	24	-	-	PUNCT
fnp-3910	43	25	krasg12v	krasg12v	NOUN
fnp-3910	43	26	)	)	PUNCT
fnp-3910	43	27	inhibited	inhibit	VERB
fnp-3910	43	28	bavm	bavm	ADJ
fnp-3910	43	29	growth	growth	NOUN
fnp-3910	43	30	suggesting	suggest	VERB
fnp-3910	43	31	the	the	DET
fnp-3910	43	32	mek	mek	PROPN
fnp-3910	43	33	/	/	SYM
fnp-3910	43	34	erk	erk	PROPN
fnp-3910	43	35	signaling	signal	VERB
fnp-3910	43	36	is	be	AUX
fnp-3910	43	37	critical	critical	ADJ
fnp-3910	43	38	in	in	ADP
fnp-3910	43	39	bavm	bavm	PROPN
fnp-3910	43	40	development	development	NOUN
fnp-3910	43	41	induced	induce	VERB
fnp-3910	43	42	by	by	ADP
fnp-3910	43	43	kras	kras	PROPN
fnp-3910	43	44	mutation	mutation	NOUN
fnp-3910	43	45	(	(	PUNCT
fnp-3910	43	46	park	park	NOUN
fnp-3910	43	47	et	et	PROPN
fnp-3910	43	48	al	al	PROPN
fnp-3910	43	49	.	.	PROPN
fnp-3910	43	50	,	,	PUNCT
fnp-3910	43	51	2021	2021	NUM
fnp-3910	43	52	)	)	PUNCT
fnp-3910	43	53	.	.	PUNCT
fnp-3910	44	1	topic	topic	NOUN
fnp-3910	44	2	2	2	NUM
fnp-3910	44	3	:	:	PUNCT
fnp-3910	44	4	pik3ca	pik3ca	NOUN
fnp-3910	44	5	and	and	CCONJ
fnp-3910	44	6	ccm	ccm	NOUN
fnp-3910	44	7	mutations	mutation	NOUN
fnp-3910	44	8	fuel	fuel	NOUN
fnp-3910	44	9	cavernomas	cavernoma	NOUN
fnp-3910	44	10	through	through	ADP
fnp-3910	44	11	a	a	DET
fnp-3910	44	12	cancer	cancer	NOUN
fnp-3910	44	13	-	-	PUNCT
fnp-3910	44	14	like	like	ADJ
fnp-3910	44	15	mechanism	mechanism	NOUN
fnp-3910	44	16	another	another	DET
fnp-3910	44	17	interesting	interesting	ADJ
fnp-3910	44	18	work	work	NOUN
fnp-3910	44	19	,	,	PUNCT
fnp-3910	44	20	also	also	ADV
fnp-3910	44	21	on	on	ADP
fnp-3910	44	22	the	the	DET
fnp-3910	44	23	topic	topic	NOUN
fnp-3910	44	24	of	of	ADP
fnp-3910	44	25	brain	brain	NOUN
fnp-3910	44	26	vascular	vascular	ADJ
fnp-3910	44	27	malformations	malformation	NOUN
fnp-3910	44	28	,	,	PUNCT
fnp-3910	44	29	comes	come	VERB
fnp-3910	44	30	from	from	ADP
fnp-3910	44	31	the	the	DET
fnp-3910	44	32	laboratory	laboratory	NOUN
fnp-3910	44	33	of	of	ADP
fnp-3910	44	34	dr	dr	PROPN
fnp-3910	44	35	.	.	PROPN
fnp-3910	44	36	khan	khan	PROPN
fnp-3910	44	37	(	(	PUNCT
fnp-3910	44	38	4	4	NUM
fnp-3910	44	39	)	)	PUNCT
fnp-3910	44	40	.	.	PUNCT
fnp-3910	45	1	in	in	ADP
fnp-3910	45	2	this	this	DET
fnp-3910	45	3	work	work	NOUN
fnp-3910	45	4	the	the	DET
fnp-3910	45	5	authors	author	NOUN
fnp-3910	45	6	focused	focus	VERB
fnp-3910	45	7	on	on	ADP
fnp-3910	45	8	cerebral	cerebral	ADJ
fnp-3910	45	9	cavernous	cavernous	ADJ
fnp-3910	45	10	malformations	malformation	NOUN
fnp-3910	45	11	(	(	PUNCT
fnp-3910	45	12	ccms	ccms	NOUN
fnp-3910	45	13	)	)	PUNCT
fnp-3910	45	14	rather	rather	ADV
fnp-3910	45	15	than	than	ADP
fnp-3910	45	16	the	the	DET
fnp-3910	45	17	avms	avms	NOUN
fnp-3910	45	18	explored	explore	VERB
fnp-3910	45	19	in	in	ADP
fnp-3910	45	20	the	the	DET
fnp-3910	45	21	prior	prior	ADJ
fnp-3910	45	22	manuscript	manuscript	NOUN
fnp-3910	45	23	.	.	PUNCT
fnp-3910	46	1	ccms	ccms	PROPN
fnp-3910	46	2	develop	develop	VERB
fnp-3910	46	3	due	due	ADP
fnp-3910	46	4	to	to	ADP
fnp-3910	46	5	inactivation	inactivation	NOUN
fnp-3910	46	6	of	of	ADP
fnp-3910	46	7	the	the	DET
fnp-3910	46	8	endothelial	endothelial	ADJ
fnp-3910	46	9	ccm	ccm	NOUN
fnp-3910	46	10	protein	protein	NOUN
fnp-3910	46	11	complex	complex	NOUN
fnp-3910	46	12	,	,	PUNCT
fnp-3910	46	13	which	which	PRON
fnp-3910	46	14	is	be	AUX
fnp-3910	46	15	needed	need	VERB
fnp-3910	46	16	to	to	PART
fnp-3910	46	17	decrease	decrease	VERB
fnp-3910	46	18	the	the	DET
fnp-3910	46	19	activity	activity	NOUN
fnp-3910	46	20	of	of	ADP
fnp-3910	46	21	the	the	DET
fnp-3910	46	22	kinase	kinase	PROPN
fnp-3910	46	23	mekk3	mekk3	PROPN
fnp-3910	46	24	.	.	PUNCT
fnp-3910	47	1	these	these	DET
fnp-3910	47	2	malformations	malformation	NOUN
fnp-3910	47	3	can	can	AUX
fnp-3910	47	4	lead	lead	VERB
fnp-3910	47	5	to	to	ADP
fnp-3910	47	6	intracerebral	intracerebral	ADJ
fnp-3910	47	7	hemorrhages	hemorrhage	NOUN
fnp-3910	47	8	and	and	CCONJ
fnp-3910	47	9	seizures	seizure	NOUN
fnp-3910	47	10	,	,	PUNCT
fnp-3910	47	11	and	and	CCONJ
fnp-3910	47	12	often	often	ADV
fnp-3910	47	13	affect	affect	VERB
fnp-3910	47	14	younger	young	ADJ
fnp-3910	47	15	individuals	individual	NOUN
fnp-3910	47	16	.	.	PUNCT
fnp-3910	48	1	the	the	DET
fnp-3910	48	2	clinical	clinical	ADJ
fnp-3910	48	3	spectrum	spectrum	NOUN
fnp-3910	48	4	of	of	ADP
fnp-3910	48	5	disease	disease	NOUN
fnp-3910	48	6	presentation	presentation	NOUN
fnp-3910	48	7	,	,	PUNCT
fnp-3910	48	8	including	include	VERB
fnp-3910	48	9	growth	growth	NOUN
fnp-3910	48	10	and	and	CCONJ
fnp-3910	48	11	rupture	rupture	NOUN
fnp-3910	48	12	,	,	PUNCT
fnp-3910	48	13	varies	vary	VERB
fnp-3910	48	14	between	between	ADP
fnp-3910	48	15	individuals	individual	NOUN
fnp-3910	48	16	.	.	PUNCT
fnp-3910	49	1	some	some	DET
fnp-3910	49	2	ccms	ccms	NOUN
fnp-3910	49	3	are	be	AUX
fnp-3910	49	4	clinically	clinically	ADV
fnp-3910	49	5	silent	silent	ADJ
fnp-3910	49	6	,	,	PUNCT
fnp-3910	49	7	whereas	whereas	SCONJ
fnp-3910	49	8	others	other	NOUN
fnp-3910	49	9	grow	grow	VERB
fnp-3910	49	10	rapidly	rapidly	ADV
fnp-3910	49	11	and	and	CCONJ
fnp-3910	49	12	are	be	AUX
fnp-3910	49	13	at	at	ADP
fnp-3910	49	14	risk	risk	NOUN
fnp-3910	49	15	for	for	ADP
fnp-3910	49	16	repeated	repeat	VERB
fnp-3910	49	17	hemorrhages	hemorrhage	NOUN
fnp-3910	49	18	.	.	PUNCT
fnp-3910	50	1	identifying	identify	VERB
fnp-3910	50	2	which	which	DET
fnp-3910	50	3	subset	subset	NOUN
fnp-3910	50	4	of	of	ADP
fnp-3910	50	5	ccms	ccms	NOUN
fnp-3910	50	6	are	be	AUX
fnp-3910	50	7	more	more	ADV
fnp-3910	50	8	likely	likely	ADJ
fnp-3910	50	9	to	to	PART
fnp-3910	50	10	become	become	VERB
fnp-3910	50	11	symptomatic	symptomatic	ADJ
fnp-3910	50	12	is	be	AUX
fnp-3910	50	13	important	important	ADJ
fnp-3910	50	14	,	,	PUNCT
fnp-3910	50	15	as	as	SCONJ
fnp-3910	50	16	surgical	surgical	ADJ
fnp-3910	50	17	resection	resection	NOUN
fnp-3910	50	18	may	may	AUX
fnp-3910	50	19	be	be	AUX
fnp-3910	50	20	warranted	warrant	VERB
fnp-3910	50	21	.	.	PUNCT
fnp-3910	51	1	however	however	ADV
fnp-3910	51	2	,	,	PUNCT
fnp-3910	51	3	surgery	surgery	NOUN
fnp-3910	51	4	has	have	VERB
fnp-3910	51	5	its	its	PRON
fnp-3910	51	6	own	own	ADJ
fnp-3910	51	7	risks	risk	NOUN
fnp-3910	51	8	,	,	PUNCT
fnp-3910	51	9	and	and	CCONJ
fnp-3910	51	10	patients	patient	NOUN
fnp-3910	51	11	often	often	ADV
fnp-3910	51	12	have	have	VERB
fnp-3910	51	13	multiple	multiple	ADJ
fnp-3910	51	14	lesions	lesion	NOUN
fnp-3910	51	15	.	.	PUNCT
fnp-3910	52	1	genetic	genetic	ADJ
fnp-3910	52	2	studies	study	NOUN
fnp-3910	52	3	have	have	AUX
fnp-3910	52	4	implicated	implicate	VERB
fnp-3910	52	5	a	a	DET
fnp-3910	52	6	monogenic	monogenic	ADJ
fnp-3910	52	7	basis	basis	NOUN
fnp-3910	52	8	for	for	ADP
fnp-3910	52	9	ccm	ccm	NOUN
fnp-3910	52	10	disease	disease	NOUN
fnp-3910	52	11	associated	associate	VERB
fnp-3910	52	12	with	with	ADP
fnp-3910	52	13	biallelic	biallelic	ADJ
fnp-3910	52	14	loss	loss	NOUN
fnp-3910	52	15	of	of	ADP
fnp-3910	52	16	function	function	NOUN
fnp-3910	52	17	mutations	mutation	NOUN
fnp-3910	52	18	in	in	ADP
fnp-3910	52	19	three	three	NUM
fnp-3910	52	20	genes	gene	NOUN
fnp-3910	52	21	,	,	PUNCT
fnp-3910	52	22	krit1	krit1	PROPN
fnp-3910	52	23	,	,	PUNCT
fnp-3910	52	24	ccm2	ccm2	NOUN
fnp-3910	52	25	,	,	PUNCT
fnp-3910	52	26	and	and	CCONJ
fnp-3910	52	27	pdcd10	pdcd10	NOUN
fnp-3910	52	28	,	,	PUNCT
fnp-3910	52	29	that	that	PRON
fnp-3910	52	30	encode	encode	VERB
fnp-3910	52	31	the	the	DET
fnp-3910	52	32	components	component	NOUN
fnp-3910	52	33	of	of	ADP
fnp-3910	52	34	a	a	DET
fnp-3910	52	35	heterotrimeric	heterotrimeric	ADJ
fnp-3910	52	36	ccm	ccm	NOUN
fnp-3910	52	37	protein	protein	NOUN
fnp-3910	52	38	complex	complex	NOUN
fnp-3910	52	39	,	,	PUNCT
fnp-3910	52	40	as	as	SCONJ
fnp-3910	52	41	described	describe	VERB
fnp-3910	52	42	by	by	ADP
fnp-3910	52	43	others	other	NOUN
fnp-3910	52	44	.	.	PUNCT
fnp-3910	53	1	in	in	ADP
fnp-3910	53	2	this	this	DET
fnp-3910	53	3	work	work	NOUN
fnp-3910	53	4	,	,	PUNCT
fnp-3910	53	5	the	the	DET
fnp-3910	53	6	authors	author	NOUN
fnp-3910	53	7	demonstrate	demonstrate	VERB
fnp-3910	53	8	that	that	SCONJ
fnp-3910	53	9	the	the	DET
fnp-3910	53	10	growth	growth	NOUN
fnp-3910	53	11	of	of	ADP
fnp-3910	53	12	ccms	ccms	NOUN
fnp-3910	53	13	requires	require	VERB
fnp-3910	53	14	increased	increase	VERB
fnp-3910	53	15	signaling	signal	VERB
fnp-3910	53	16	through	through	ADP
fnp-3910	53	17	the	the	DET
fnp-3910	53	18	phosphatidylinositol-3	phosphatidylinositol-3	PROPN
fnp-3910	53	19	-	-	PUNCT
fnp-3910	53	20	kinase	kinase	NOUN
fnp-3910	53	21	(	(	PUNCT
fnp-3910	53	22	pi3k)-mtor	pi3k)-mtor	NOUN
fnp-3910	53	23	pathway	pathway	NOUN
fnp-3910	53	24	as	as	ADV
fnp-3910	53	25	well	well	ADV
fnp-3910	53	26	as	as	ADP
fnp-3910	53	27	loss	loss	NOUN
fnp-3910	53	28	of	of	ADP
fnp-3910	53	29	function	function	NOUN
fnp-3910	53	30	of	of	ADP
fnp-3910	53	31	the	the	DET
fnp-3910	53	32	ccm	ccm	NOUN
fnp-3910	53	33	complex	complex	NOUN
fnp-3910	53	34	.	.	PUNCT
fnp-3910	54	1	this	this	DET
fnp-3910	54	2	work	work	NOUN
fnp-3910	54	3	identified	identify	VERB
fnp-3910	54	4	that	that	SCONJ
fnp-3910	54	5	symptomatic	symptomatic	ADJ
fnp-3910	54	6	ccm	ccm	NOUN
fnp-3910	54	7	disease	disease	NOUN
fnp-3910	54	8	arises	arise	VERB
fnp-3910	54	9	through	through	ADP
fnp-3910	54	10	a	a	DET
fnp-3910	54	11	cancer	cancer	NOUN
fnp-3910	54	12	-	-	PUNCT
fnp-3910	54	13	like	like	ADJ
fnp-3910	54	14	program	program	NOUN
fnp-3910	54	15	,	,	PUNCT
fnp-3910	54	16	with	with	ADP
fnp-3910	54	17	the	the	DET
fnp-3910	54	18	accumulation	accumulation	NOUN
fnp-3910	54	19	of	of	ADP
fnp-3910	54	20	multiple	multiple	ADJ
fnp-3910	54	21	somatic	somatic	ADJ
fnp-3910	54	22	mutations	mutation	NOUN
fnp-3910	54	23	in	in	ADP
fnp-3910	54	24	the	the	DET
fnp-3910	54	25	same	same	ADJ
fnp-3910	54	26	cell	cell	NOUN
fnp-3910	54	27	.	.	PUNCT
fnp-3910	55	1	this	this	DET
fnp-3910	55	2	results	result	VERB
fnp-3910	55	3	in	in	ADP
fnp-3910	55	4	both	both	CCONJ
fnp-3910	55	5	the	the	DET
fnp-3910	55	6	loss	loss	NOUN
fnp-3910	55	7	of	of	ADP
fnp-3910	55	8	a	a	DET
fnp-3910	55	9	vascular	vascular	ADJ
fnp-3910	55	10	malformation	malformation	NOUN
fnp-3910	55	11	suppressor	suppressor	NOUN
fnp-3910	55	12	gene	gene	NOUN
fnp-3910	55	13	(	(	PUNCT
fnp-3910	55	14	i.e.	i.e.	X
fnp-3910	55	15	,	,	PUNCT
fnp-3910	55	16	the	the	DET
fnp-3910	55	17	ccm	ccm	NOUN
fnp-3910	55	18	gene	gene	NOUN
fnp-3910	55	19	)	)	PUNCT
fnp-3910	55	20	and	and	CCONJ
fnp-3910	55	21	the	the	DET
fnp-3910	55	22	gain	gain	NOUN
fnp-3910	55	23	of	of	ADP
fnp-3910	55	24	vascular	vascular	ADJ
fnp-3910	55	25	malformation	malformation	NOUN
fnp-3910	55	26	growth	growth	NOUN
fnp-3910	55	27	gene	gene	NOUN
fnp-3910	55	28	(	(	PUNCT
fnp-3910	55	29	i.e.	i.e.	X
fnp-3910	55	30	pik3ca	pik3ca	NOUN
fnp-3910	55	31	)	)	PUNCT
fnp-3910	55	32	.	.	PUNCT
fnp-3910	56	1	the	the	DET
fnp-3910	56	2	authors	author	NOUN
fnp-3910	56	3	found	find	VERB
fnp-3910	56	4	somatic	somatic	ADJ
fnp-3910	56	5	gain	gain	NOUN
fnp-3910	56	6	-	-	PUNCT
fnp-3910	56	7	of	of	ADP
fnp-3910	56	8	-	-	PUNCT
fnp-3910	56	9	function	function	NOUN
fnp-3910	56	10	mutations	mutation	NOUN
fnp-3910	56	11	in	in	ADP
fnp-3910	56	12	pik3ca	pik3ca	PROPN
fnp-3910	56	13	and	and	CCONJ
fnp-3910	56	14	loss	loss	NOUN
fnp-3910	56	15	-	-	PUNCT
fnp-3910	56	16	of	of	ADP
fnp-3910	56	17	-	-	PUNCT
fnp-3910	56	18	function	function	NOUN
fnp-3910	56	19	mutations	mutation	NOUN
fnp-3910	56	20	in	in	ADP
fnp-3910	56	21	the	the	DET
fnp-3910	56	22	ccm	ccm	NOUN
fnp-3910	56	23	complex	complex	NOUN
fnp-3910	56	24	in	in	ADP
fnp-3910	56	25	the	the	DET
fnp-3910	56	26	same	same	ADJ
fnp-3910	56	27	cells	cell	NOUN
fnp-3910	56	28	in	in	ADP
fnp-3910	56	29	the	the	DET
fnp-3910	56	30	majority	majority	NOUN
fnp-3910	56	31	of	of	ADP
fnp-3910	56	32	human	human	PROPN
fnp-3910	56	33	ccms	ccms	PROPN
fnp-3910	56	34	.	.	PUNCT
fnp-3910	57	1	they	they	PRON
fnp-3910	57	2	then	then	ADV
fnp-3910	57	3	moved	move	VERB
fnp-3910	57	4	to	to	ADP
fnp-3910	57	5	mouse	mouse	NOUN
fnp-3910	57	6	models	model	NOUN
fnp-3910	57	7	and	and	CCONJ
fnp-3910	57	8	found	find	VERB
fnp-3910	57	9	that	that	SCONJ
fnp-3910	57	10	the	the	DET
fnp-3910	57	11	growth	growth	NOUN
fnp-3910	57	12	of	of	ADP
fnp-3910	57	13	ccms	ccms	NOUN
fnp-3910	57	14	requires	require	VERB
fnp-3910	57	15	both	both	DET
fnp-3910	57	16	pi3k	pi3k	PROPN
fnp-3910	57	17	gain	gain	NOUN
fnp-3910	57	18	of	of	ADP
fnp-3910	57	19	function	function	NOUN
fnp-3910	57	20	(	(	PUNCT
fnp-3910	57	21	gof	gof	NOUN
fnp-3910	57	22	)	)	PUNCT
fnp-3910	57	23	and	and	CCONJ
fnp-3910	57	24	ccm	ccm	NOUN
fnp-3910	57	25	loss	loss	NOUN
fnp-3910	57	26	of	of	ADP
fnp-3910	57	27	function	function	NOUN
fnp-3910	57	28	(	(	PUNCT
fnp-3910	57	29	lof	lof	PROPN
fnp-3910	57	30	)	)	PUNCT
fnp-3910	57	31	in	in	ADP
fnp-3910	57	32	endothelial	endothelial	ADJ
fnp-3910	57	33	cells	cell	NOUN
fnp-3910	57	34	,	,	PUNCT
fnp-3910	57	35	as	as	SCONJ
fnp-3910	57	36	both	both	PRON
fnp-3910	57	37	were	be	AUX
fnp-3910	57	38	required	require	VERB
fnp-3910	57	39	for	for	ADP
fnp-3910	57	40	ccm	ccm	NOUN
fnp-3910	57	41	development	development	NOUN
fnp-3910	57	42	.	.	PUNCT
fnp-3910	58	1	both	both	DET
fnp-3910	58	2	ccm	ccm	NOUN
fnp-3910	58	3	loss	loss	NOUN
fnp-3910	58	4	of	of	ADP
fnp-3910	58	5	function	function	NOUN
fnp-3910	58	6	and	and	CCONJ
fnp-3910	58	7	increased	increase	VERB
fnp-3910	58	8	expression	expression	NOUN
fnp-3910	58	9	of	of	ADP
fnp-3910	58	10	the	the	DET
fnp-3910	58	11	transcription	transcription	NOUN
fnp-3910	58	12	factor	factor	NOUN
fnp-3910	58	13	klf4	klf4	NOUN
fnp-3910	58	14	(	(	PUNCT
fnp-3910	58	15	a	a	DET
fnp-3910	58	16	downstream	downstream	ADJ
fnp-3910	58	17	effector	effector	NOUN
fnp-3910	58	18	of	of	ADP
fnp-3910	58	19	mekk3	mekk3	NOUN
fnp-3910	58	20	)	)	PUNCT
fnp-3910	58	21	increased	increase	VERB
fnp-3910	58	22	mtor	mtor	NOUN
fnp-3910	58	23	signaling	signal	VERB
fnp-3910	58	24	in	in	ADP
fnp-3910	58	25	endothelial	endothelial	ADJ
fnp-3910	58	26	cells	cell	NOUN
fnp-3910	58	27	.	.	PUNCT
fnp-3910	59	1	importantly	importantly	ADV
fnp-3910	59	2	,	,	PUNCT
fnp-3910	59	3	the	the	DET
fnp-3910	59	4	authors	author	NOUN
fnp-3910	59	5	then	then	ADV
fnp-3910	59	6	went	go	VERB
fnp-3910	59	7	on	on	ADP
fnp-3910	59	8	to	to	PART
fnp-3910	59	9	utilize	utilize	VERB
fnp-3910	59	10	rapamycin	rapamycin	NOUN
fnp-3910	59	11	,	,	PUNCT
fnp-3910	59	12	a	a	DET
fnp-3910	59	13	mtorc1	mtorc1	NOUN
fnp-3910	59	14	inhibitor	inhibitor	NOUN
fnp-3910	59	15	in	in	ADP
fnp-3910	59	16	mice	mouse	NOUN
fnp-3910	59	17	.	.	PUNCT
fnp-3910	60	1	as	as	ADP
fnp-3910	60	2	single	single	ADJ
fnp-3910	60	3	dose	dose	NOUN
fnp-3910	60	4	given	give	VERB
fnp-3910	60	5	at	at	ADP
fnp-3910	60	6	p2	p2	PROPN
fnp-3910	60	7	reduced	reduce	VERB
fnp-3910	60	8	ccm	ccm	NOUN
fnp-3910	60	9	formation	formation	NOUN
fnp-3910	60	10	by	by	ADP
fnp-3910	60	11	75	75	NUM
fnp-3910	60	12	%	%	NOUN
fnp-3910	60	13	.	.	PUNCT
fnp-3910	61	1	in	in	ADP
fnp-3910	61	2	adult	adult	NOUN
fnp-3910	61	3	mice	mouse	NOUN
fnp-3910	61	4	,	,	PUNCT
fnp-3910	61	5	chronic	chronic	ADJ
fnp-3910	61	6	administration	administration	NOUN
fnp-3910	61	7	of	of	ADP
fnp-3910	61	8	rapamycin	rapamycin	NOUN
fnp-3910	61	9	effectively	effectively	ADV
fnp-3910	61	10	blocked	block	VERB
fnp-3910	61	11	the	the	DET
fnp-3910	61	12	formation	formation	NOUN
fnp-3910	61	13	of	of	ADP
fnp-3910	61	14	ccms	ccms	NOUN
fnp-3910	61	15	in	in	ADP
fnp-3910	61	16	mouse	mouse	NOUN
fnp-3910	61	17	models	model	NOUN
fnp-3910	61	18	.	.	PUNCT
fnp-3910	62	1	this	this	DET
fnp-3910	62	2	work	work	NOUN
fnp-3910	62	3	suggests	suggest	VERB
fnp-3910	62	4	that	that	SCONJ
fnp-3910	62	5	there	there	PRON
fnp-3910	62	6	is	be	VERB
fnp-3910	62	7	a	a	DET
fnp-3910	62	8	“	"	PUNCT
fnp-3910	62	9	triple	triple	ADJ
fnp-3910	62	10	-	-	PUNCT
fnp-3910	62	11	hit	hit	VERB
fnp-3910	62	12	”	"	PUNCT
fnp-3910	62	13	mechanism	mechanism	NOUN
fnp-3910	62	14	involving	involve	VERB
fnp-3910	62	15	the	the	DET
fnp-3910	62	16	acquisition	acquisition	NOUN
fnp-3910	62	17	of	of	ADP
fnp-3910	62	18	as	as	ADV
fnp-3910	62	19	many	many	ADJ
fnp-3910	62	20	as	as	ADP
fnp-3910	62	21	three	three	NUM
fnp-3910	62	22	distinct	distinct	ADJ
fnp-3910	62	23	genetic	genetic	ADJ
fnp-3910	62	24	mutations	mutation	NOUN
fnp-3910	62	25	that	that	PRON
fnp-3910	62	26	culminate	culminate	VERB
fnp-3910	62	27	in	in	ADP
fnp-3910	62	28	ccm	ccm	PROPN
fnp-3910	62	29	lof	lof	PROPN
fnp-3910	62	30	and	and	CCONJ
fnp-3910	62	31	pik3ca	pik3ca	VERB
fnp-3910	62	32	gof	gof	NOUN
fnp-3910	62	33	and	and	CCONJ
fnp-3910	62	34	contribute	contribute	VERB
fnp-3910	62	35	to	to	ADP
fnp-3910	62	36	rapidly	rapidly	ADV
fnp-3910	62	37	growing	grow	VERB
fnp-3910	62	38	,	,	PUNCT
fnp-3910	62	39	clinically	clinically	ADV
fnp-3910	62	40	symptomatic	symptomatic	ADJ
fnp-3910	62	41	ccms	ccms	NOUN
fnp-3910	62	42	.	.	PUNCT
fnp-3910	63	1	this	this	DET
fnp-3910	63	2	three	three	NUM
fnp-3910	63	3	-	-	PUNCT
fnp-3910	63	4	hit	hit	VERB
fnp-3910	63	5	mechanism	mechanism	NOUN
fnp-3910	63	6	is	be	AUX
fnp-3910	63	7	analogous	analogous	ADJ
fnp-3910	63	8	to	to	ADP
fnp-3910	63	9	cancer	cancer	NOUN
fnp-3910	63	10	,	,	PUNCT
fnp-3910	63	11	in	in	ADP
fnp-3910	63	12	which	which	PRON
fnp-3910	63	13	aggressive	aggressive	ADJ
fnp-3910	63	14	vascular	vascular	ADJ
fnp-3910	63	15	malformations	malformation	NOUN
fnp-3910	63	16	arise	arise	VERB
fnp-3910	63	17	through	through	ADP
fnp-3910	63	18	both	both	DET
fnp-3910	63	19	the	the	DET
fnp-3910	63	20	loss	loss	NOUN
fnp-3910	63	21	of	of	ADP
fnp-3910	63	22	vascular	vascular	ADJ
fnp-3910	63	23	“	"	PUNCT
fnp-3910	63	24	suppressor	suppressor	NOUN
fnp-3910	63	25	genes	gene	NOUN
fnp-3910	63	26	”	"	PUNCT
fnp-3910	63	27	that	that	PRON
fnp-3910	63	28	limit	limit	VERB
fnp-3910	63	29	vessel	vessel	NOUN
fnp-3910	63	30	growth	growth	NOUN
fnp-3910	63	31	and	and	CCONJ
fnp-3910	63	32	gain	gain	NOUN
fnp-3910	63	33	of	of	ADP
fnp-3910	63	34	function	function	NOUN
fnp-3910	63	35	of	of	ADP
fnp-3910	63	36	a	a	DET
fnp-3910	63	37	vascular	vascular	ADJ
fnp-3910	63	38	“	"	PUNCT
fnp-3910	63	39	oncogene	oncogene	NOUN
fnp-3910	63	40	”	"	PUNCT
fnp-3910	63	41	that	that	PRON
fnp-3910	63	42	then	then	ADV
fnp-3910	63	43	stimulates	stimulate	VERB
fnp-3910	63	44	excess	excess	ADJ
fnp-3910	63	45	vascular	vascular	ADJ
fnp-3910	63	46	growth	growth	NOUN
fnp-3910	63	47	.	.	PUNCT
fnp-3910	64	1	importantly	importantly	ADV
fnp-3910	64	2	,	,	PUNCT
fnp-3910	64	3	these	these	DET
fnp-3910	64	4	findings	finding	NOUN
fnp-3910	64	5	suggest	suggest	VERB
fnp-3910	64	6	that	that	SCONJ
fnp-3910	64	7	aggressive	aggressive	ADJ
fnp-3910	64	8	ccms	ccms	NOUN
fnp-3910	64	9	may	may	AUX
fnp-3910	64	10	be	be	AUX
fnp-3910	64	11	treatable	treatable	ADJ
fnp-3910	64	12	using	use	VERB
fnp-3910	64	13	clinically	clinically	ADV
fnp-3910	64	14	approved	approve	VERB
fnp-3910	64	15	mtorc1	mtorc1	NOUN
fnp-3910	64	16	inhibitors	inhibitor	NOUN
fnp-3910	64	17	.	.	PUNCT
fnp-3910	65	1	topic	topic	NOUN
fnp-3910	65	2	3	3	NUM
fnp-3910	65	3	:	:	PUNCT
fnp-3910	65	4	treg	treg	PROPN
fnp-3910	65	5	cell	cell	NOUN
fnp-3910	65	6	-	-	PUNCT
fnp-3910	65	7	derived	derive	VERB
fnp-3910	65	8	osteopontin	osteopontin	NOUN
fnp-3910	65	9	promotes	promote	VERB
fnp-3910	65	10	microglia	microglia	ADJ
fnp-3910	65	11	-	-	PUNCT
fnp-3910	65	12	mediated	mediate	VERB
fnp-3910	65	13	white	white	ADJ
fnp-3910	65	14	matter	matter	NOUN
fnp-3910	65	15	repair	repair	NOUN
fnp-3910	65	16	after	after	ADP
fnp-3910	65	17	ischemic	ischemic	ADJ
fnp-3910	65	18	stroke	stroke	NOUN
fnp-3910	65	19	in	in	ADP
fnp-3910	65	20	this	this	DET
fnp-3910	65	21	paper	paper	NOUN
fnp-3910	65	22	(	(	PUNCT
fnp-3910	65	23	5	5	NUM
fnp-3910	65	24	)	)	PUNCT
fnp-3910	65	25	the	the	DET
fnp-3910	65	26	role	role	NOUN
fnp-3910	65	27	of	of	ADP
fnp-3910	65	28	regulatory	regulatory	ADJ
fnp-3910	65	29	t	t	NOUN
fnp-3910	65	30	cells	cell	NOUN
fnp-3910	65	31	(	(	PUNCT
fnp-3910	65	32	treg	treg	PROPN
fnp-3910	65	33	)	)	PUNCT
fnp-3910	65	34	in	in	ADP
fnp-3910	65	35	stroke	stroke	NOUN
fnp-3910	65	36	recovery	recovery	NOUN
fnp-3910	65	37	was	be	AUX
fnp-3910	65	38	examined	examine	VERB
fnp-3910	65	39	.	.	PUNCT
fnp-3910	66	1	shi	shi	PROPN
fnp-3910	66	2	et	et	PROPN
fnp-3910	66	3	al	al	PROPN
fnp-3910	66	4	.	.	PROPN
fnp-3910	66	5	sorted	sort	VERB
fnp-3910	66	6	infiltrating	infiltrating	ADJ
fnp-3910	66	7	immune	immune	ADJ
fnp-3910	66	8	cells	cell	NOUN
fnp-3910	66	9	from	from	ADP
fnp-3910	66	10	the	the	DET
fnp-3910	66	11	ischemic	ischemic	ADJ
fnp-3910	66	12	brain	brain	NOUN
fnp-3910	66	13	at	at	ADP
fnp-3910	66	14	5	5	NUM
fnp-3910	66	15	and	and	CCONJ
fnp-3910	66	16	14	14	NUM
fnp-3910	66	17	days	day	NOUN
fnp-3910	66	18	after	after	ADP
fnp-3910	66	19	transient	transient	ADJ
fnp-3910	66	20	middle	middle	ADJ
fnp-3910	66	21	cerebral	cerebral	ADJ
fnp-3910	66	22	artery	artery	NOUN
fnp-3910	66	23	occlusion	occlusion	NOUN
fnp-3910	66	24	(	(	PUNCT
fnp-3910	66	25	mcao	mcao	NOUN
fnp-3910	66	26	)	)	PUNCT
fnp-3910	66	27	.	.	PUNCT
fnp-3910	67	1	the	the	DET
fnp-3910	67	2	numbers	number	NOUN
fnp-3910	67	3	of	of	ADP
fnp-3910	67	4	t	t	NOUN
fnp-3910	67	5	cells	cell	NOUN
fnp-3910	67	6	increased	increase	VERB
fnp-3910	67	7	robustly	robustly	ADV
fnp-3910	67	8	from	from	ADP
fnp-3910	67	9	5	5	NUM
fnp-3910	67	10	to	to	PART
fnp-3910	67	11	14	14	NUM
fnp-3910	67	12	days	day	NOUN
fnp-3910	67	13	after	after	ADP
fnp-3910	67	14	stroke	stroke	NOUN
fnp-3910	67	15	,	,	PUNCT
fnp-3910	67	16	suggesting	suggest	VERB
fnp-3910	67	17	a	a	DET
fnp-3910	67	18	possible	possible	ADJ
fnp-3910	67	19	role	role	NOUN
fnp-3910	67	20	of	of	ADP
fnp-3910	67	21	these	these	DET
fnp-3910	67	22	cells	cell	NOUN
fnp-3910	67	23	in	in	ADP
fnp-3910	67	24	stroke	stroke	NOUN
fnp-3910	67	25	pathophysiology	pathophysiology	NOUN
fnp-3910	67	26	and	and	CCONJ
fnp-3910	67	27	recovery	recovery	NOUN
fnp-3910	67	28	.	.	PUNCT
fnp-3910	68	1	the	the	DET
fnp-3910	68	2	authors	author	NOUN
fnp-3910	68	3	subclustered	subclustere	VERB
fnp-3910	68	4	and	and	CCONJ
fnp-3910	68	5	more	more	ADV
fnp-3910	68	6	deeply	deeply	ADV
fnp-3910	68	7	assessed	assess	VERB
fnp-3910	68	8	the	the	DET
fnp-3910	68	9	14	14	NUM
fnp-3910	68	10	-	-	PUNCT
fnp-3910	68	11	day	day	NOUN
fnp-3910	68	12	t	t	NOUN
fnp-3910	68	13	cell	cell	NOUN
fnp-3910	68	14	population	population	NOUN
fnp-3910	68	15	.	.	PUNCT
fnp-3910	69	1	seven	seven	NUM
fnp-3910	69	2	subclusters	subcluster	NOUN
fnp-3910	69	3	were	be	AUX
fnp-3910	69	4	identified	identify	VERB
fnp-3910	69	5	,	,	PUNCT
fnp-3910	69	6	including	include	VERB
fnp-3910	69	7	cd4	cd4	PROPN
fnp-3910	69	8	+	+	PROPN
fnp-3910	69	9	treg	treg	PROPN
fnp-3910	69	10	cells	cell	NOUN
fnp-3910	69	11	,	,	PUNCT
fnp-3910	69	12	cd4	cd4	PROPN
fnp-3910	69	13	+	+	PROPN
fnp-3910	69	14	memory	memory	NOUN
fnp-3910	69	15	t	t	NOUN
fnp-3910	69	16	cells	cell	NOUN
fnp-3910	69	17	,	,	PUNCT
fnp-3910	69	18	natural	natural	ADJ
fnp-3910	69	19	killer	killer	NOUN
fnp-3910	69	20	t	t	PROPN
fnp-3910	69	21	(	(	PUNCT
fnp-3910	69	22	nkt	nkt	NOUN
fnp-3910	69	23	)	)	PUNCT
fnp-3910	69	24	cells	cell	NOUN
fnp-3910	69	25	,	,	PUNCT
fnp-3910	69	26	macrophage	macrophage	ADJ
fnp-3910	69	27	-	-	PUNCT
fnp-3910	69	28	like	like	ADJ
fnp-3910	69	29	t	t	NOUN
fnp-3910	69	30	cells	cell	NOUN
fnp-3910	69	31	,	,	PUNCT
fnp-3910	69	32	and	and	CCONJ
fnp-3910	69	33	populations	population	NOUN
fnp-3910	69	34	of	of	ADP
fnp-3910	69	35	cd8	cd8	PROPN
fnp-3910	69	36	+	+	PROPN
fnp-3910	69	37	t	t	PROPN
fnp-3910	69	38	effector	effector	NOUN
fnp-3910	69	39	cells	cell	NOUN
fnp-3910	69	40	.	.	PUNCT
fnp-3910	70	1	the	the	DET
fnp-3910	70	2	distinct	distinct	ADJ
fnp-3910	70	3	treg	treg	PROPN
fnp-3910	70	4	cell	cell	PROPN
fnp-3910	70	5	subcluster	subcluster	NOUN
fnp-3910	70	6	expressed	express	VERB
fnp-3910	70	7	transcripts	transcript	NOUN
fnp-3910	70	8	of	of	ADP
fnp-3910	70	9	canonical	canonical	ADJ
fnp-3910	70	10	treg	treg	PROPN
fnp-3910	70	11	cell	cell	NOUN
fnp-3910	70	12	markers	marker	NOUN
fnp-3910	70	13	such	such	ADJ
fnp-3910	70	14	as	as	ADP
fnp-3910	70	15	cd4	cd4	PROPN
fnp-3910	70	16	,	,	PUNCT
fnp-3910	70	17	il2ra	il2ra	PRON
fnp-3910	70	18	(	(	PUNCT
fnp-3910	70	19	cd25	cd25	PROPN
fnp-3910	70	20	)	)	PUNCT
fnp-3910	70	21	,	,	PUNCT
fnp-3910	70	22	foxp3	foxp3	NOUN
fnp-3910	70	23	,	,	PUNCT
fnp-3910	70	24	and	and	CCONJ
fnp-3910	70	25	ikzf2	ikzf2	NOUN
fnp-3910	70	26	(	(	PUNCT
fnp-3910	70	27	helios	helios	PROPN
fnp-3910	70	28	)	)	PUNCT
fnp-3910	70	29	,	,	PUNCT
fnp-3910	70	30	which	which	PRON
fnp-3910	70	31	is	be	AUX
fnp-3910	70	32	essential	essential	ADJ
fnp-3910	70	33	for	for	ADP
fnp-3910	70	34	t	t	PROPN
fnp-3910	70	35	cell	cell	NOUN
fnp-3910	70	36	regulatory	regulatory	ADJ
fnp-3910	70	37	function	function	NOUN
fnp-3910	70	38	.	.	PUNCT
fnp-3910	71	1	temporal	temporal	ADJ
fnp-3910	71	2	changes	change	NOUN
fnp-3910	71	3	in	in	ADP
fnp-3910	71	4	the	the	DET
fnp-3910	71	5	cd3	cd3	PROPN
fnp-3910	71	6	+	+	PROPN
fnp-3910	71	7	cd4	cd4	PROPN
fnp-3910	71	8	+	+	NOUN
fnp-3910	71	9	cd25+foxp3	cd25+foxp3	ADJ
fnp-3910	71	10	+	+	NUM
fnp-3910	71	11	treg	treg	PROPN
fnp-3910	71	12	cell	cell	NOUN
fnp-3910	71	13	population	population	NOUN
fnp-3910	71	14	were	be	AUX
fnp-3910	71	15	assessed	assess	VERB
fnp-3910	71	16	in	in	ADP
fnp-3910	71	17	the	the	DET
fnp-3910	71	18	ischemic	ischemic	ADJ
fnp-3910	71	19	brain	brain	NOUN
fnp-3910	71	20	using	use	VERB
fnp-3910	71	21	flow	flow	NOUN
fnp-3910	71	22	cytometry	cytometry	NOUN
fnp-3910	71	23	at	at	ADP
fnp-3910	71	24	different	different	ADJ
fnp-3910	71	25	time	time	NOUN
fnp-3910	71	26	points	point	NOUN
fnp-3910	71	27	(	(	PUNCT
fnp-3910	71	28	3	3	NUM
fnp-3910	71	29	,	,	PUNCT
fnp-3910	71	30	5	5	NUM
fnp-3910	71	31	,	,	PUNCT
fnp-3910	71	32	7	7	NUM
fnp-3910	71	33	,	,	PUNCT
fnp-3910	71	34	14	14	NUM
fnp-3910	71	35	,	,	PUNCT
fnp-3910	71	36	and	and	CCONJ
fnp-3910	71	37	35	35	NUM
fnp-3910	71	38	days	day	NOUN
fnp-3910	71	39	)	)	PUNCT
fnp-3910	71	40	.	.	PUNCT
fnp-3910	72	1	minimal	minimal	ADJ
fnp-3910	72	2	treg	treg	PROPN
fnp-3910	72	3	cell	cell	NOUN
fnp-3910	72	4	infiltration	infiltration	NOUN
fnp-3910	72	5	was	be	AUX
fnp-3910	72	6	observed	observe	VERB
fnp-3910	72	7	3	3	NUM
fnp-3910	72	8	and	and	CCONJ
fnp-3910	72	9	5	5	NUM
fnp-3910	72	10	days	day	NOUN
fnp-3910	72	11	after	after	ADP
fnp-3910	72	12	mcao	mcao	NOUN
fnp-3910	72	13	.	.	PUNCT
fnp-3910	73	1	the	the	DET
fnp-3910	73	2	number	number	NOUN
fnp-3910	73	3	of	of	ADP
fnp-3910	73	4	infiltrating	infiltrate	VERB
fnp-3910	73	5	treg	treg	PROPN
fnp-3910	73	6	cells	cell	NOUN
fnp-3910	73	7	significantly	significantly	ADV
fnp-3910	73	8	increased	increase	VERB
fnp-3910	73	9	from	from	ADP
fnp-3910	73	10	7	7	NUM
fnp-3910	73	11	days	day	NOUN
fnp-3910	73	12	onward	onward	ADV
fnp-3910	73	13	,	,	PUNCT
fnp-3910	73	14	increasing	increase	VERB
fnp-3910	73	15	until	until	ADP
fnp-3910	73	16	at	at	ADP
fnp-3910	73	17	least	least	ADV
fnp-3910	73	18	35	35	NUM
fnp-3910	73	19	days	day	NOUN
fnp-3910	73	20	post	post	NOUN
fnp-3910	73	21	stroke	stroke	NOUN
fnp-3910	73	22	.	.	PUNCT
fnp-3910	74	1	the	the	DET
fnp-3910	74	2	visualization	visualization	NOUN
fnp-3910	74	3	of	of	ADP
fnp-3910	74	4	t	t	NOUN
fnp-3910	74	5	-	-	PUNCT
fnp-3910	74	6	distributed	distribute	VERB
fnp-3910	74	7	stochastic	stochastic	ADJ
fnp-3910	74	8	neighbor	neighbor	NOUN
fnp-3910	74	9	embedding	embed	VERB
fnp-3910	74	10	(	(	PUNCT
fnp-3910	74	11	visne	visne	NOUN
fnp-3910	74	12	)	)	PUNCT
fnp-3910	74	13	map	map	NOUN
fnp-3910	74	14	of	of	ADP
fnp-3910	74	15	flow	flow	NOUN
fnp-3910	74	16	cytometry	cytometry	NOUN
fnp-3910	74	17	data	datum	NOUN
fnp-3910	74	18	revealed	reveal	VERB
fnp-3910	74	19	a	a	DET
fnp-3910	74	20	prominent	prominent	ADJ
fnp-3910	74	21	treg	treg	PROPN
fnp-3910	74	22	cell	cell	NOUN
fnp-3910	74	23	population	population	NOUN
fnp-3910	74	24	among	among	ADP
fnp-3910	74	25	all	all	DET
fnp-3910	74	26	cd4	cd4	PROPN
fnp-3910	74	27	+	+	PROPN
fnp-3910	74	28	t	t	NOUN
fnp-3910	74	29	cells	cell	NOUN
fnp-3910	74	30	in	in	ADP
fnp-3910	74	31	single	single	ADJ
fnp-3910	74	32	-	-	PUNCT
fnp-3910	74	33	cell	cell	NOUN
fnp-3910	74	34	brain	brain	NOUN
fnp-3910	74	35	suspensions	suspension	NOUN
fnp-3910	74	36	collected	collect	VERB
fnp-3910	74	37	14	14	NUM
fnp-3910	74	38	days	day	NOUN
fnp-3910	74	39	after	after	ADP
fnp-3910	74	40	stroke	stroke	NOUN
fnp-3910	74	41	.	.	PUNCT
fnp-3910	75	1	these	these	DET
fnp-3910	75	2	cells	cell	NOUN
fnp-3910	75	3	expressed	express	VERB
fnp-3910	75	4	cd25	cd25	PROPN
fnp-3910	75	5	and	and	CCONJ
fnp-3910	75	6	foxp3	foxp3	PROPN
fnp-3910	75	7	.	.	PUNCT
fnp-3910	76	1	consistent	consistent	ADJ
fnp-3910	76	2	with	with	ADP
fnp-3910	76	3	recent	recent	ADJ
fnp-3910	76	4	studies	study	NOUN
fnp-3910	76	5	,	,	PUNCT
fnp-3910	76	6	the	the	DET
fnp-3910	76	7	majority	majority	NOUN
fnp-3910	76	8	of	of	ADP
fnp-3910	76	9	brain	brain	NOUN
fnp-3910	76	10	-	-	PUNCT
fnp-3910	76	11	infiltrating	infiltrate	VERB
fnp-3910	76	12	treg	treg	PROPN
fnp-3910	76	13	cells	cell	NOUN
fnp-3910	76	14	were	be	AUX
fnp-3910	76	15	found	find	VERB
fnp-3910	76	16	to	to	PART
fnp-3910	76	17	be	be	AUX
fnp-3910	76	18	helios+	helios+	ADV
fnp-3910	76	19	,	,	PUNCT
fnp-3910	76	20	a	a	DET
fnp-3910	76	21	population	population	NOUN
fnp-3910	76	22	recently	recently	ADV
fnp-3910	76	23	identified	identify	VERB
fnp-3910	76	24	as	as	ADP
fnp-3910	76	25	phenotypically	phenotypically	ADV
fnp-3910	76	26	active	active	ADJ
fnp-3910	76	27	treg	treg	NOUN
fnp-3910	76	28	cells	cell	NOUN
fnp-3910	76	29	.	.	PUNCT
fnp-3910	77	1	these	these	DET
fnp-3910	77	2	cells	cell	NOUN
fnp-3910	77	3	accumulated	accumulate	VERB
fnp-3910	77	4	near	near	ADP
fnp-3910	77	5	white	white	ADJ
fnp-3910	77	6	matter	matter	NOUN
fnp-3910	77	7	.	.	PUNCT
fnp-3910	78	1	higher	high	ADJ
fnp-3910	78	2	percentages	percentage	NOUN
fnp-3910	78	3	of	of	ADP
fnp-3910	78	4	infiltrating	infiltrate	VERB
fnp-3910	78	5	treg	treg	PROPN
fnp-3910	78	6	cells	cell	NOUN
fnp-3910	78	7	in	in	ADP
fnp-3910	78	8	the	the	DET
fnp-3910	78	9	ischemic	ischemic	ADJ
fnp-3910	78	10	brain	brain	NOUN
fnp-3910	78	11	expressed	express	VERB
fnp-3910	78	12	osteopontin	osteopontin	PROPN
fnp-3910	78	13	(	(	PUNCT
fnp-3910	78	14	opn	opn	PROPN
fnp-3910	78	15	)	)	PUNCT
fnp-3910	78	16	compared	compare	VERB
fnp-3910	78	17	with	with	ADP
fnp-3910	78	18	circulating	circulate	VERB
fnp-3910	78	19	treg	treg	PROPN
fnp-3910	78	20	cells	cell	NOUN
fnp-3910	78	21	from	from	ADP
fnp-3910	78	22	sham	sham	NOUN
fnp-3910	78	23	or	or	CCONJ
fnp-3910	78	24	stroke	stroke	NOUN
fnp-3910	78	25	mice	mouse	NOUN
fnp-3910	78	26	.	.	PUNCT
fnp-3910	79	1	bioinformatic	bioinformatic	ADJ
fnp-3910	79	2	analyses	analysis	NOUN
fnp-3910	79	3	predicted	predict	VERB
fnp-3910	79	4	strong	strong	ADJ
fnp-3910	79	5	interactions	interaction	NOUN
fnp-3910	79	6	between	between	ADP
fnp-3910	79	7	treg	treg	PROPN
fnp-3910	79	8	cells	cell	NOUN
fnp-3910	79	9	and	and	CCONJ
fnp-3910	79	10	microglia	microglia	NOUN
fnp-3910	79	11	through	through	ADP
fnp-3910	79	12	opn	opn	PROPN
fnp-3910	79	13	and	and	CCONJ
fnp-3910	79	14	integrin	integrin	NOUN
fnp-3910	79	15	receptors	receptor	NOUN
fnp-3910	79	16	,	,	PUNCT
fnp-3910	79	17	which	which	PRON
fnp-3910	79	18	were	be	AUX
fnp-3910	79	19	then	then	ADV
fnp-3910	79	20	confirmed	confirm	VERB
fnp-3910	79	21	experimentally	experimentally	ADV
fnp-3910	79	22	by	by	ADP
fnp-3910	79	23	a	a	DET
fnp-3910	79	24	series	series	NOUN
fnp-3910	79	25	of	of	ADP
fnp-3910	79	26	in	in	ADP
fnp-3910	79	27	vivo	vivo	NOUN
fnp-3910	79	28	and	and	CCONJ
fnp-3910	79	29	in	in	ADP
fnp-3910	79	30	vitro	vitro	X
fnp-3910	79	31	studies	study	NOUN
fnp-3910	79	32	.	.	PUNCT
fnp-3910	80	1	the	the	DET
fnp-3910	80	2	authors	author	NOUN
fnp-3910	80	3	then	then	ADV
fnp-3910	80	4	selectively	selectively	ADV
fnp-3910	80	5	depleted	deplete	VERB
fnp-3910	80	6	tregs	treg	NOUN
fnp-3910	80	7	using	use	VERB
fnp-3910	80	8	a	a	DET
fnp-3910	80	9	diphtheria	diphtheria	NOUN
fnp-3910	80	10	toxin	toxin	NOUN
fnp-3910	80	11	method	method	NOUN
fnp-3910	80	12	and	and	CCONJ
fnp-3910	80	13	found	find	VERB
fnp-3910	80	14	that	that	SCONJ
fnp-3910	80	15	loss	loss	NOUN
fnp-3910	80	16	of	of	ADP
fnp-3910	80	17	these	these	DET
fnp-3910	80	18	cells	cell	NOUN
fnp-3910	80	19	impaired	impair	VERB
fnp-3910	80	20	motor	motor	NOUN
fnp-3910	80	21	recovery	recovery	NOUN
fnp-3910	80	22	and	and	CCONJ
fnp-3910	80	23	reduced	reduce	VERB
fnp-3910	80	24	myelin	myelin	NOUN
fnp-3910	80	25	coverage	coverage	NOUN
fnp-3910	80	26	,	,	PUNCT
fnp-3910	80	27	which	which	PRON
fnp-3910	80	28	was	be	AUX
fnp-3910	80	29	confirmed	confirm	VERB
fnp-3910	80	30	by	by	ADP
fnp-3910	80	31	whole	whole	ADJ
fnp-3910	80	32	brain	brain	NOUN
fnp-3910	80	33	ex	ex	X
fnp-3910	80	34	vivo	vivo	NOUN
fnp-3910	80	35	diffusion	diffusion	NOUN
fnp-3910	80	36	tensor	tensor	NOUN
fnp-3910	80	37	imaging	imaging	NOUN
fnp-3910	80	38	and	and	CCONJ
fnp-3910	80	39	electron	electron	NOUN
fnp-3910	80	40	microscopy	microscopy	NOUN
fnp-3910	80	41	.	.	PUNCT
fnp-3910	81	1	the	the	DET
fnp-3910	81	2	beneficial	beneficial	ADJ
fnp-3910	81	3	effects	effect	NOUN
fnp-3910	81	4	of	of	ADP
fnp-3910	81	5	treg	treg	PROPN
fnp-3910	81	6	cells	cell	NOUN
fnp-3910	81	7	were	be	AUX
fnp-3910	81	8	linked	link	VERB
fnp-3910	81	9	to	to	ADP
fnp-3910	81	10	oligodendrogenesis	oligodendrogenesis	NOUN
fnp-3910	81	11	that	that	PRON
fnp-3910	81	12	was	be	AUX
fnp-3910	81	13	dependent	dependent	ADJ
fnp-3910	81	14	on	on	ADP
fnp-3910	81	15	microglia	microglia	ADJ
fnp-3910	81	16	.	.	PUNCT
fnp-3910	82	1	microglia	microglia	ADJ
fnp-3910	82	2	depletion	depletion	NOUN
fnp-3910	82	3	,	,	PUNCT
fnp-3910	82	4	but	but	CCONJ
fnp-3910	82	5	not	not	PART
fnp-3910	82	6	t	t	NOUN
fnp-3910	82	7	cell	cell	NOUN
fnp-3910	82	8	lymphopenia	lymphopenia	NOUN
fnp-3910	82	9	,	,	PUNCT
fnp-3910	82	10	mitigated	mitigate	VERB
fnp-3910	82	11	the	the	DET
fnp-3910	82	12	beneficial	beneficial	ADJ
fnp-3910	82	13	effects	effect	NOUN
fnp-3910	82	14	of	of	ADP
fnp-3910	82	15	transferred	transfer	VERB
fnp-3910	82	16	treg	treg	PROPN
fnp-3910	82	17	cells	cell	NOUN
fnp-3910	82	18	on	on	ADP
fnp-3910	82	19	white	white	ADJ
fnp-3910	82	20	matter	matter	NOUN
fnp-3910	82	21	regeneration	regeneration	NOUN
fnp-3910	82	22	.	.	PUNCT
fnp-3910	83	1	mechanistically	mechanistically	ADV
fnp-3910	83	2	,	,	PUNCT
fnp-3910	83	3	treg	treg	PROPN
fnp-3910	83	4	cell	cell	NOUN
fnp-3910	83	5	-	-	PUNCT
fnp-3910	83	6	derived	derive	VERB
fnp-3910	83	7	osteopontin	osteopontin	NOUN
fnp-3910	83	8	acted	act	VERB
fnp-3910	83	9	through	through	ADP
fnp-3910	83	10	integrin	integrin	NOUN
fnp-3910	83	11	receptors	receptor	NOUN
fnp-3910	83	12	on	on	ADP
fnp-3910	83	13	microglia	microglia	NOUN
fnp-3910	83	14	to	to	PART
fnp-3910	83	15	enhance	enhance	VERB
fnp-3910	83	16	microglial	microglial	ADJ
fnp-3910	83	17	reparative	reparative	ADJ
fnp-3910	83	18	activity	activity	NOUN
fnp-3910	83	19	,	,	PUNCT
fnp-3910	83	20	consequently	consequently	ADV
fnp-3910	83	21	promoting	promote	VERB
fnp-3910	83	22	oligodendrogenesis	oligodendrogenesis	NOUN
fnp-3910	83	23	and	and	CCONJ
fnp-3910	83	24	white	white	ADJ
fnp-3910	83	25	matter	matter	NOUN
fnp-3910	83	26	repair	repair	NOUN
fnp-3910	83	27	.	.	PUNCT
fnp-3910	84	1	these	these	DET
fnp-3910	84	2	results	result	NOUN
fnp-3910	84	3	confirm	confirm	VERB
fnp-3910	84	4	that	that	SCONJ
fnp-3910	84	5	treg	treg	PROPN
fnp-3910	84	6	cell	cell	NOUN
fnp-3910	84	7	-	-	PUNCT
fnp-3910	84	8	microglia	microglia	NOUN
fnp-3910	84	9	interactions	interaction	NOUN
fnp-3910	84	10	enhance	enhance	VERB
fnp-3910	84	11	a	a	DET
fnp-3910	84	12	reparative	reparative	ADJ
fnp-3910	84	13	microglial	microglial	ADJ
fnp-3910	84	14	phenotype	phenotype	NOUN
fnp-3910	84	15	that	that	PRON
fnp-3910	84	16	promotes	promote	VERB
fnp-3910	84	17	opc	opc	PROPN
fnp-3910	84	18	differentiation	differentiation	NOUN
fnp-3910	84	19	.	.	PUNCT
fnp-3910	85	1	therefore	therefore	ADV
fnp-3910	85	2	,	,	PUNCT
fnp-3910	85	3	treg	treg	PROPN
fnp-3910	85	4	cells	cell	NOUN
fnp-3910	85	5	appear	appear	VERB
fnp-3910	85	6	to	to	PART
fnp-3910	85	7	contribute	contribute	VERB
fnp-3910	85	8	to	to	ADP
fnp-3910	85	9	brain	brain	NOUN
fnp-3910	85	10	repair	repair	NOUN
fnp-3910	85	11	via	via	ADP
fnp-3910	85	12	both	both	CCONJ
fnp-3910	85	13	indirect	indirect	ADJ
fnp-3910	85	14	immunomodulation	immunomodulation	NOUN
fnp-3910	85	15	of	of	ADP
fnp-3910	85	16	microglial	microglial	ADJ
fnp-3910	85	17	responses	response	NOUN
fnp-3910	85	18	as	as	ADV
fnp-3910	85	19	well	well	ADV
fnp-3910	85	20	as	as	ADP
fnp-3910	85	21	direct	direct	ADJ
fnp-3910	85	22	trophic	trophic	ADJ
fnp-3910	85	23	effects	effect	NOUN
fnp-3910	85	24	.	.	PUNCT
fnp-3910	86	1	boosting	boost	VERB
fnp-3910	86	2	treg	treg	PROPN
fnp-3910	86	3	cell	cell	NOUN
fnp-3910	86	4	numbers	number	NOUN
fnp-3910	86	5	could	could	AUX
fnp-3910	86	6	be	be	AUX
fnp-3910	86	7	a	a	DET
fnp-3910	86	8	practical	practical	ADJ
fnp-3910	86	9	approach	approach	NOUN
fnp-3910	86	10	to	to	PART
fnp-3910	86	11	improve	improve	VERB
fnp-3910	86	12	wm	wm	PROPN
fnp-3910	86	13	repair	repair	NOUN
fnp-3910	86	14	and	and	CCONJ
fnp-3910	86	15	functional	functional	ADJ
fnp-3910	86	16	recovery	recovery	NOUN
fnp-3910	86	17	after	after	ADP
fnp-3910	86	18	stroke	stroke	NOUN
fnp-3910	86	19	.	.	PUNCT
fnp-3910	87	1	topic	topic	NOUN
fnp-3910	87	2	4	4	NUM
fnp-3910	87	3	:	:	PUNCT
fnp-3910	87	4	heterogeneity	heterogeneity	NOUN
fnp-3910	87	5	of	of	ADP
fnp-3910	87	6	meningeal	meningeal	ADJ
fnp-3910	87	7	b	b	PROPN
fnp-3910	87	8	cells	cell	NOUN
fnp-3910	87	9	reveals	reveal	VERB
fnp-3910	87	10	a	a	DET
fnp-3910	87	11	lymphopoietic	lymphopoietic	ADJ
fnp-3910	87	12	niche	niche	NOUN
fnp-3910	87	13	at	at	ADP
fnp-3910	87	14	the	the	DET
fnp-3910	87	15	cns	cns	PROPN
fnp-3910	87	16	borders	border	NOUN
fnp-3910	87	17	meningeal	meningeal	ADJ
fnp-3910	87	18	immune	immune	ADJ
fnp-3910	87	19	cells	cell	NOUN
fnp-3910	87	20	are	be	AUX
fnp-3910	87	21	thought	think	VERB
fnp-3910	87	22	to	to	PART
fnp-3910	87	23	originate	originate	VERB
fnp-3910	87	24	from	from	ADP
fnp-3910	87	25	the	the	DET
fnp-3910	87	26	systemic	systemic	ADJ
fnp-3910	87	27	blood	blood	NOUN
fnp-3910	87	28	circulation	circulation	NOUN
fnp-3910	87	29	.	.	PUNCT
fnp-3910	88	1	however	however	ADV
fnp-3910	88	2	,	,	PUNCT
fnp-3910	88	3	recent	recent	ADJ
fnp-3910	88	4	findings	finding	NOUN
fnp-3910	88	5	of	of	ADP
fnp-3910	88	6	developmentally	developmentally	ADV
fnp-3910	88	7	immature	immature	ADJ
fnp-3910	88	8	b	b	NOUN
fnp-3910	88	9	cells	cell	NOUN
fnp-3910	88	10	in	in	ADP
fnp-3910	88	11	the	the	DET
fnp-3910	88	12	mouse	mouse	NOUN
fnp-3910	88	13	central	central	ADJ
fnp-3910	88	14	nervous	nervous	ADJ
fnp-3910	88	15	system	system	NOUN
fnp-3910	88	16	question	question	NOUN
fnp-3910	88	17	this	this	DET
fnp-3910	88	18	assumption	assumption	NOUN
fnp-3910	88	19	.	.	PUNCT
fnp-3910	89	1	brioschi	brioschi	PROPN
fnp-3910	89	2	et	et	PROPN
fnp-3910	89	3	al	al	PROPN
fnp-3910	89	4	.	.	PROPN
fnp-3910	90	1	(	(	PUNCT
fnp-3910	90	2	6	6	NUM
fnp-3910	90	3	)	)	PUNCT
fnp-3910	90	4	used	use	VERB
fnp-3910	90	5	single	single	ADJ
fnp-3910	90	6	cell	cell	NOUN
fnp-3910	90	7	analysis	analysis	NOUN
fnp-3910	90	8	from	from	ADP
fnp-3910	90	9	parabiotic	parabiotic	ADJ
fnp-3910	90	10	and	and	CCONJ
fnp-3910	90	11	chimeric	chimeric	ADJ
fnp-3910	90	12	mouse	mouse	NOUN
fnp-3910	90	13	models	model	NOUN
fnp-3910	90	14	to	to	PART
fnp-3910	90	15	demonstrate	demonstrate	VERB
fnp-3910	90	16	that	that	SCONJ
fnp-3910	90	17	the	the	DET
fnp-3910	90	18	skull	skull	NOUN
fnp-3910	90	19	bone	bone	NOUN
fnp-3910	90	20	marrow	marrow	PROPN
fnp-3910	90	21	contains	contain	VERB
fnp-3910	90	22	a	a	DET
fnp-3910	90	23	hematopoietic	hematopoietic	ADJ
fnp-3910	90	24	niche	niche	NOUN
fnp-3910	90	25	from	from	ADP
fnp-3910	90	26	which	which	PRON
fnp-3910	90	27	extravascular	extravascular	ADJ
fnp-3910	90	28	meningeal	meningeal	NOUN
fnp-3910	90	29	b	b	PROPN
fnp-3910	90	30	cells	cell	NOUN
fnp-3910	90	31	can	can	AUX
fnp-3910	90	32	arise	arise	VERB
fnp-3910	90	33	to	to	PART
fnp-3910	90	34	participate	participate	VERB
fnp-3910	90	35	in	in	ADP
fnp-3910	90	36	the	the	DET
fnp-3910	90	37	local	local	ADJ
fnp-3910	90	38	immune	immune	ADJ
fnp-3910	90	39	response	response	NOUN
fnp-3910	90	40	.	.	PUNCT
fnp-3910	91	1	meningeal	meningeal	ADJ
fnp-3910	91	2	b	b	PROPN
fnp-3910	91	3	cells	cell	NOUN
fnp-3910	91	4	are	be	AUX
fnp-3910	91	5	capable	capable	ADJ
fnp-3910	91	6	of	of	ADP
fnp-3910	91	7	trafficking	traffic	VERB
fnp-3910	91	8	through	through	ADP
fnp-3910	91	9	meningeal	meningeal	ADJ
fnp-3910	91	10	lymphatics	lymphatic	NOUN
fnp-3910	91	11	to	to	ADP
fnp-3910	91	12	the	the	DET
fnp-3910	91	13	cervical	cervical	ADJ
fnp-3910	91	14	lymph	lymph	NOUN
fnp-3910	91	15	nodes	node	NOUN
fnp-3910	91	16	,	,	PUNCT
fnp-3910	91	17	enabling	enable	VERB
fnp-3910	91	18	them	they	PRON
fnp-3910	91	19	to	to	PART
fnp-3910	91	20	participate	participate	VERB
fnp-3910	91	21	in	in	ADP
fnp-3910	91	22	antigen	antigen	ADJ
fnp-3910	91	23	presentation	presentation	NOUN
fnp-3910	91	24	linking	link	VERB
fnp-3910	91	25	brain	brain	NOUN
fnp-3910	91	26	and	and	CCONJ
fnp-3910	91	27	systemic	systemic	ADJ
fnp-3910	91	28	immunity	immunity	NOUN
fnp-3910	91	29	.	.	PUNCT
fnp-3910	92	1	these	these	DET
fnp-3910	92	2	meningeal	meningeal	ADJ
fnp-3910	92	3	b	b	PROPN
fnp-3910	92	4	cells	cell	NOUN
fnp-3910	92	5	are	be	AUX
fnp-3910	92	6	composed	compose	VERB
fnp-3910	92	7	of	of	ADP
fnp-3910	92	8	a	a	DET
fnp-3910	92	9	heterogeneous	heterogeneous	ADJ
fnp-3910	92	10	population	population	NOUN
fnp-3910	92	11	with	with	ADP
fnp-3910	92	12	respect	respect	NOUN
fnp-3910	92	13	to	to	ADP
fnp-3910	92	14	their	their	PRON
fnp-3910	92	15	developmental	developmental	ADJ
fnp-3910	92	16	and	and	CCONJ
fnp-3910	92	17	maturity	maturity	NOUN
fnp-3910	92	18	stage	stage	NOUN
fnp-3910	92	19	,	,	PUNCT
fnp-3910	92	20	with	with	ADP
fnp-3910	92	21	late	late	ADJ
fnp-3910	92	22	(	(	PUNCT
fnp-3910	92	23	b220lowcd43low	b220lowcd43low	NOUN
fnp-3910	92	24	)	)	PUNCT
fnp-3910	92	25	,	,	PUNCT
fnp-3910	92	26	and	and	CCONJ
fnp-3910	92	27	mature	mature	ADJ
fnp-3910	92	28	(	(	PUNCT
fnp-3910	92	29	b220highcd43−	b220highcd43−	PROPN
fnp-3910	92	30	)	)	PUNCT
fnp-3910	92	31	subsets	subset	NOUN
fnp-3910	92	32	representing	represent	VERB
fnp-3910	92	33	over	over	ADP
fnp-3910	92	34	80	80	NUM
fnp-3910	92	35	%	%	NOUN
fnp-3910	92	36	of	of	ADP
fnp-3910	92	37	the	the	DET
fnp-3910	92	38	total	total	ADJ
fnp-3910	92	39	b	b	PROPN
fnp-3910	92	40	cell	cell	NOUN
fnp-3910	92	41	population	population	NOUN
fnp-3910	92	42	.	.	PUNCT
fnp-3910	93	1	this	this	PRON
fnp-3910	93	2	was	be	AUX
fnp-3910	93	3	confirmed	confirm	VERB
fnp-3910	93	4	by	by	ADP
fnp-3910	93	5	single	single	ADJ
fnp-3910	93	6	cell	cell	NOUN
fnp-3910	93	7	rna	rna	NOUN
fnp-3910	93	8	sequencing	sequence	VERB
fnp-3910	93	9	(	(	PUNCT
fnp-3910	93	10	scrna	scrna	NOUN
fnp-3910	93	11	-	-	PUNCT
fnp-3910	93	12	seq	seq	NOUN
fnp-3910	93	13	)	)	PUNCT
fnp-3910	93	14	and	and	CCONJ
fnp-3910	93	15	cytof	cytof	NOUN
fnp-3910	93	16	mass	mass	PROPN
fnp-3910	93	17	spectrometry	spectrometry	NOUN
fnp-3910	93	18	.	.	PUNCT
fnp-3910	94	1	scrna	scrna	NOUN
fnp-3910	94	2	-	-	PUNCT
fnp-3910	94	3	seq	seq	NOUN
fnp-3910	94	4	analysis	analysis	NOUN
fnp-3910	94	5	showed	show	VERB
fnp-3910	94	6	that	that	SCONJ
fnp-3910	94	7	the	the	DET
fnp-3910	94	8	meningeal	meningeal	NOUN
fnp-3910	94	9	and	and	CCONJ
fnp-3910	94	10	skull	skull	NOUN
fnp-3910	94	11	bone	bone	NOUN
fnp-3910	94	12	marrow	marrow	PROPN
fnp-3910	95	1	b	b	PROPN
fnp-3910	95	2	cells	cell	NOUN
fnp-3910	95	3	exhibited	exhibit	VERB
fnp-3910	95	4	overlapping	overlap	VERB
fnp-3910	95	5	transcriptomic	transcriptomic	ADJ
fnp-3910	95	6	phenotypes	phenotype	NOUN
fnp-3910	95	7	,	,	PUNCT
fnp-3910	95	8	and	and	CCONJ
fnp-3910	95	9	that	that	SCONJ
fnp-3910	95	10	these	these	PRON
fnp-3910	95	11	were	be	AUX
fnp-3910	95	12	distinct	distinct	ADJ
fnp-3910	95	13	from	from	ADP
fnp-3910	95	14	the	the	DET
fnp-3910	95	15	blood	blood	NOUN
fnp-3910	95	16	-	-	PUNCT
fnp-3910	95	17	sourced	source	VERB
fnp-3910	95	18	b	b	NOUN
fnp-3910	95	19	cells	cell	NOUN
fnp-3910	95	20	.	.	PUNCT
fnp-3910	96	1	targeted	target	VERB
fnp-3910	96	2	gamma	gamma	NOUN
fnp-3910	96	3	irradiation	irradiation	NOUN
fnp-3910	96	4	of	of	ADP
fnp-3910	96	5	the	the	DET
fnp-3910	96	6	skull	skull	NOUN
fnp-3910	96	7	followed	follow	VERB
fnp-3910	96	8	by	by	ADP
fnp-3910	96	9	reconstitution	reconstitution	NOUN
fnp-3910	96	10	with	with	ADP
fnp-3910	96	11	donor	donor	NOUN
fnp-3910	96	12	bone	bone	NOUN
fnp-3910	96	13	marrow	marrow	NOUN
fnp-3910	96	14	cells	cell	NOUN
fnp-3910	96	15	was	be	AUX
fnp-3910	96	16	used	use	VERB
fnp-3910	96	17	to	to	PART
fnp-3910	96	18	generate	generate	VERB
fnp-3910	96	19	a	a	DET
fnp-3910	96	20	skull	skull	NOUN
fnp-3910	96	21	bone	bone	NOUN
fnp-3910	96	22	marrow	marrow	NOUN
fnp-3910	96	23	transplantation	transplantation	NOUN
fnp-3910	96	24	model	model	NOUN
fnp-3910	96	25	to	to	PART
fnp-3910	96	26	investigate	investigate	VERB
fnp-3910	96	27	the	the	DET
fnp-3910	96	28	origin	origin	NOUN
fnp-3910	96	29	of	of	ADP
fnp-3910	96	30	the	the	DET
fnp-3910	96	31	meningeal	meningeal	ADJ
fnp-3910	96	32	b	b	PROPN
fnp-3910	96	33	cells	cell	NOUN
fnp-3910	96	34	.	.	PUNCT
fnp-3910	97	1	the	the	DET
fnp-3910	97	2	skull	skull	NOUN
fnp-3910	97	3	bone	bone	PROPN
fnp-3910	97	4	marrow	marrow	PROPN
fnp-3910	97	5	chimera	chimera	NOUN
fnp-3910	97	6	experiments	experiment	NOUN
fnp-3910	97	7	confirmed	confirm	VERB
fnp-3910	97	8	that	that	SCONJ
fnp-3910	97	9	the	the	DET
fnp-3910	97	10	meningeal	meningeal	NOUN
fnp-3910	97	11	b	b	PROPN
fnp-3910	97	12	cells	cell	NOUN
fnp-3910	97	13	originate	originate	VERB
fnp-3910	97	14	from	from	ADP
fnp-3910	97	15	the	the	DET
fnp-3910	97	16	skull	skull	NOUN
fnp-3910	97	17	.	.	PUNCT
fnp-3910	98	1	taken	take	VERB
fnp-3910	98	2	together	together	ADV
fnp-3910	98	3	,	,	PUNCT
fnp-3910	98	4	this	this	DET
fnp-3910	98	5	study	study	NOUN
fnp-3910	98	6	showed	show	VERB
fnp-3910	98	7	that	that	SCONJ
fnp-3910	98	8	skull	skull	NOUN
fnp-3910	98	9	bone	bone	NOUN
fnp-3910	98	10	marrow	marrow	NOUN
fnp-3910	98	11	provides	provide	VERB
fnp-3910	98	12	an	an	DET
fnp-3910	98	13	accessible	accessible	ADJ
fnp-3910	98	14	source	source	NOUN
fnp-3910	98	15	of	of	ADP
fnp-3910	98	16	b	b	NOUN
fnp-3910	98	17	cells	cell	NOUN
fnp-3910	98	18	that	that	PRON
fnp-3910	98	19	are	be	AUX
fnp-3910	98	20	locally	locally	ADV
fnp-3910	98	21	educated	educate	VERB
fnp-3910	98	22	by	by	ADP
fnp-3910	98	23	cns	cns	NOUN
fnp-3910	98	24	-	-	PUNCT
fnp-3910	98	25	derived	derive	VERB
fnp-3910	98	26	antigens	antigen	NOUN
fnp-3910	98	27	.	.	PUNCT
fnp-3910	99	1	lastly	lastly	ADV
fnp-3910	99	2	,	,	PUNCT
fnp-3910	99	3	scrnaseq	scrnaseq	NOUN
fnp-3910	99	4	data	datum	NOUN
fnp-3910	99	5	showed	show	VERB
fnp-3910	99	6	an	an	DET
fnp-3910	99	7	age	age	NOUN
fnp-3910	99	8	-	-	PUNCT
fnp-3910	99	9	dependent	dependent	ADJ
fnp-3910	99	10	accumulation	accumulation	NOUN
fnp-3910	99	11	of	of	ADP
fnp-3910	99	12	blood	blood	NOUN
fnp-3910	99	13	-	-	PUNCT
fnp-3910	99	14	derived	derive	VERB
fnp-3910	99	15	antigen	antigen	NOUN
fnp-3910	99	16	-	-	PUNCT
fnp-3910	99	17	experienced	experience	VERB
fnp-3910	99	18	b	b	PROPN
fnp-3910	99	19	cells	cell	NOUN
fnp-3910	99	20	(	(	PUNCT
fnp-3910	99	21	identified	identify	VERB
fnp-3910	99	22	as	as	ADP
fnp-3910	99	23	b220highcd23−cd2+sca1	b220highcd23−cd2+sca1	NOUN
fnp-3910	99	24	+	+	CCONJ
fnp-3910	99	25	cells	cell	NOUN
fnp-3910	99	26	)	)	PUNCT
fnp-3910	99	27	in	in	ADP
fnp-3910	99	28	the	the	DET
fnp-3910	99	29	meninges	meninge	NOUN
fnp-3910	99	30	.	.	PUNCT
fnp-3910	100	1	meninges	meninge	NOUN
fnp-3910	100	2	from	from	ADP
fnp-3910	100	3	aged	aged	ADJ
fnp-3910	100	4	animals	animal	NOUN
fnp-3910	100	5	(	(	PUNCT
fnp-3910	100	6	20	20	NUM
fnp-3910	100	7	-	-	SYM
fnp-3910	100	8	25	25	NUM
fnp-3910	100	9	months	month	NOUN
fnp-3910	100	10	of	of	ADP
fnp-3910	100	11	age	age	NOUN
fnp-3910	100	12	)	)	PUNCT
fnp-3910	100	13	housed	house	VERB
fnp-3910	100	14	a	a	DET
fnp-3910	100	15	significant	significant	ADJ
fnp-3910	100	16	population	population	NOUN
fnp-3910	100	17	of	of	ADP
fnp-3910	100	18	igm+	igm+	PROPN
fnp-3910	100	19	and	and	CCONJ
fnp-3910	100	20	igg+	igg+	ADJ
fnp-3910	100	21	plasma	plasma	NOUN
fnp-3910	100	22	cells	cell	NOUN
fnp-3910	100	23	,	,	PUNCT
fnp-3910	100	24	indicating	indicate	VERB
fnp-3910	100	25	their	their	PRON
fnp-3910	100	26	antigen	antigen	ADV
fnp-3910	100	27	-	-	PUNCT
fnp-3910	100	28	experienced	experienced	ADJ
fnp-3910	100	29	status	status	NOUN
fnp-3910	100	30	.	.	PUNCT
fnp-3910	101	1	these	these	DET
fnp-3910	101	2	specific	specific	ADJ
fnp-3910	101	3	“	"	PUNCT
fnp-3910	101	4	age	age	NOUN
fnp-3910	101	5	-	-	PUNCT
fnp-3910	101	6	associated	associate	VERB
fnp-3910	101	7	b	b	PROPN
fnp-3910	101	8	cells	cell	NOUN
fnp-3910	101	9	”	"	PUNCT
fnp-3910	101	10	(	(	PUNCT
fnp-3910	101	11	abcs	abc	NOUN
fnp-3910	101	12	)	)	PUNCT
fnp-3910	101	13	accumulating	accumulate	VERB
fnp-3910	101	14	in	in	ADP
fnp-3910	101	15	the	the	DET
fnp-3910	101	16	meninges	meninge	NOUN
fnp-3910	101	17	with	with	ADP
fnp-3910	101	18	aging	aging	NOUN
fnp-3910	101	19	were	be	AUX
fnp-3910	101	20	found	find	VERB
fnp-3910	101	21	to	to	PART
fnp-3910	101	22	originate	originate	VERB
fnp-3910	101	23	from	from	ADP
fnp-3910	101	24	the	the	DET
fnp-3910	101	25	peripheral	peripheral	ADJ
fnp-3910	101	26	circulation	circulation	NOUN
fnp-3910	101	27	,	,	PUNCT
fnp-3910	101	28	and	and	CCONJ
fnp-3910	101	29	represent	represent	VERB
fnp-3910	101	30	a	a	DET
fnp-3910	101	31	separate	separate	ADJ
fnp-3910	101	32	pool	pool	NOUN
fnp-3910	101	33	of	of	ADP
fnp-3910	101	34	b	b	NOUN
fnp-3910	101	35	cells	cell	NOUN
fnp-3910	101	36	from	from	ADP
fnp-3910	101	37	those	those	PRON
fnp-3910	101	38	derived	derive	VERB
fnp-3910	101	39	from	from	ADP
fnp-3910	101	40	the	the	DET
fnp-3910	101	41	calvaria	calvaria	NOUN
fnp-3910	101	42	.	.	PUNCT
fnp-3910	102	1	given	give	VERB
fnp-3910	102	2	the	the	DET
fnp-3910	102	3	importance	importance	NOUN
fnp-3910	102	4	of	of	ADP
fnp-3910	102	5	b	b	NOUN
fnp-3910	102	6	cells	cell	NOUN
fnp-3910	102	7	in	in	ADP
fnp-3910	102	8	the	the	DET
fnp-3910	102	9	regulation	regulation	NOUN
fnp-3910	102	10	of	of	ADP
fnp-3910	102	11	neuroinflammation	neuroinflammation	NOUN
fnp-3910	102	12	and	and	CCONJ
fnp-3910	102	13	autoimmunity	autoimmunity	NOUN
fnp-3910	102	14	,	,	PUNCT
fnp-3910	102	15	meningeal	meningeal	NOUN
fnp-3910	102	16	b	b	PROPN
fnp-3910	102	17	cells	cell	NOUN
fnp-3910	102	18	may	may	AUX
fnp-3910	102	19	be	be	AUX
fnp-3910	102	20	a	a	DET
fnp-3910	102	21	critical	critical	ADJ
fnp-3910	102	22	subset	subset	NOUN
fnp-3910	102	23	of	of	ADP
fnp-3910	102	24	the	the	DET
fnp-3910	102	25	adaptive	adaptive	ADJ
fnp-3910	102	26	immune	immune	ADJ
fnp-3910	102	27	cells	cell	NOUN
fnp-3910	102	28	,	,	PUNCT
fnp-3910	102	29	uniquely	uniquely	ADV
fnp-3910	102	30	positioned	position	VERB
fnp-3910	102	31	to	to	PART
fnp-3910	102	32	contribute	contribute	VERB
fnp-3910	102	33	to	to	ADP
fnp-3910	102	34	the	the	DET
fnp-3910	102	35	pool	pool	NOUN
fnp-3910	102	36	of	of	ADP
fnp-3910	102	37	self	self	NOUN
fnp-3910	102	38	-	-	PUNCT
fnp-3910	102	39	reactive	reactive	NOUN
fnp-3910	102	40	b	b	NOUN
fnp-3910	102	41	cells	cell	NOUN
fnp-3910	102	42	seen	see	VERB
fnp-3910	102	43	with	with	ADP
fnp-3910	102	44	aging	age	VERB
fnp-3910	102	45	(	(	PUNCT
fnp-3910	102	46	see	see	VERB
fnp-3910	102	47	next	next	ADJ
fnp-3910	102	48	paper	paper	NOUN
fnp-3910	102	49	)	)	PUNCT
fnp-3910	102	50	.	.	PUNCT
fnp-3910	103	1	topic	topic	NOUN
fnp-3910	103	2	5	5	NUM
fnp-3910	103	3	:	:	PUNCT
fnp-3910	103	4	single	single	ADJ
fnp-3910	103	5	-	-	PUNCT
fnp-3910	103	6	cell	cell	NOUN
fnp-3910	103	7	profiling	profiling	NOUN
fnp-3910	103	8	of	of	ADP
fnp-3910	103	9	cns	cns	PROPN
fnp-3910	103	10	border	border	NOUN
fnp-3910	103	11	compartment	compartment	NOUN
fnp-3910	103	12	leukocytes	leukocyte	NOUN
fnp-3910	103	13	reveals	reveal	VERB
fnp-3910	103	14	that	that	SCONJ
fnp-3910	103	15	b	b	NOUN
fnp-3910	103	16	cells	cell	NOUN
fnp-3910	103	17	and	and	CCONJ
fnp-3910	103	18	their	their	PRON
fnp-3910	103	19	progenitors	progenitor	NOUN
fnp-3910	103	20	reside	reside	VERB
fnp-3910	103	21	in	in	ADP
fnp-3910	103	22	non	non	ADJ
fnp-3910	103	23	-	-	ADJ
fnp-3910	103	24	diseased	diseased	ADJ
fnp-3910	103	25	meninges	meninge	NOUN
fnp-3910	103	26	central	central	ADJ
fnp-3910	103	27	nervous	nervous	ADJ
fnp-3910	103	28	system	system	NOUN
fnp-3910	103	29	(	(	PUNCT
fnp-3910	103	30	cns	cns	NOUN
fnp-3910	103	31	)	)	PUNCT
fnp-3910	103	32	meninges	meninge	NOUN
fnp-3910	103	33	(	(	PUNCT
fnp-3910	103	34	dura	dura	NOUN
fnp-3910	103	35	,	,	PUNCT
fnp-3910	103	36	arachnoid	arachnoid	NOUN
fnp-3910	103	37	,	,	PUNCT
fnp-3910	103	38	and	and	CCONJ
fnp-3910	103	39	pia	pia	PROPN
fnp-3910	103	40	)	)	PUNCT
fnp-3910	103	41	surround	surround	VERB
fnp-3910	103	42	the	the	DET
fnp-3910	103	43	cns	cns	NOUN
fnp-3910	103	44	tissue	tissue	NOUN
fnp-3910	103	45	at	at	ADP
fnp-3910	103	46	its	its	PRON
fnp-3910	103	47	critical	critical	ADJ
fnp-3910	103	48	borders	border	NOUN
fnp-3910	103	49	.	.	PUNCT
fnp-3910	104	1	recent	recent	ADJ
fnp-3910	104	2	studies	study	NOUN
fnp-3910	104	3	examining	examine	VERB
fnp-3910	104	4	the	the	DET
fnp-3910	104	5	dural	dural	ADJ
fnp-3910	104	6	lymphatics	lymphatic	NOUN
fnp-3910	104	7	have	have	AUX
fnp-3910	104	8	highlighted	highlight	VERB
fnp-3910	104	9	the	the	DET
fnp-3910	104	10	importance	importance	NOUN
fnp-3910	104	11	of	of	ADP
fnp-3910	104	12	these	these	DET
fnp-3910	104	13	cns	cns	NOUN
fnp-3910	104	14	interfaces	interface	NOUN
fnp-3910	104	15	and	and	CCONJ
fnp-3910	104	16	their	their	PRON
fnp-3910	104	17	immune	immune	ADJ
fnp-3910	104	18	landscape	landscape	NOUN
fnp-3910	104	19	.	.	PUNCT
fnp-3910	105	1	schafflick	schafflick	PROPN
fnp-3910	105	2	et	et	PROPN
fnp-3910	105	3	al	al	PROPN
fnp-3910	105	4	.	.	PROPN
fnp-3910	106	1	(	(	PUNCT
fnp-3910	106	2	7	7	X
fnp-3910	106	3	)	)	PUNCT
fnp-3910	106	4	used	use	VERB
fnp-3910	106	5	scrna	scrna	NOUN
fnp-3910	106	6	-	-	PUNCT
fnp-3910	106	7	seq	seq	NOUN
fnp-3910	106	8	of	of	ADP
fnp-3910	106	9	sorted	sorted	ADJ
fnp-3910	106	10	leukocytes	leukocyte	NOUN
fnp-3910	106	11	from	from	ADP
fnp-3910	106	12	rat	rat	NOUN
fnp-3910	106	13	meninges	meninge	NOUN
fnp-3910	106	14	,	,	PUNCT
fnp-3910	106	15	blood	blood	NOUN
fnp-3910	106	16	,	,	PUNCT
fnp-3910	106	17	and	and	CCONJ
fnp-3910	106	18	cerebrospinal	cerebrospinal	ADJ
fnp-3910	106	19	fluid	fluid	NOUN
fnp-3910	106	20	(	(	PUNCT
fnp-3910	106	21	csf	csf	NOUN
fnp-3910	106	22	)	)	PUNCT
fnp-3910	106	23	to	to	PART
fnp-3910	106	24	identify	identify	VERB
fnp-3910	106	25	unique	unique	ADJ
fnp-3910	106	26	cell	cell	NOUN
fnp-3910	106	27	compositions	composition	NOUN
fnp-3910	106	28	within	within	ADP
fnp-3910	106	29	the	the	DET
fnp-3910	106	30	dura	dura	NOUN
fnp-3910	106	31	.	.	PROPN
fnp-3910	107	1	intravenous	intravenous	ADJ
fnp-3910	107	2	immune	immune	ADJ
fnp-3910	107	3	labeling	labeling	NOUN
fnp-3910	107	4	using	use	VERB
fnp-3910	107	5	fluorophore	fluorophore	NOUN
fnp-3910	107	6	-	-	PUNCT
fnp-3910	107	7	labeled	label	VERB
fnp-3910	107	8	cd45	cd45	PROPN
fnp-3910	107	9	(	(	PUNCT
fnp-3910	107	10	common	common	ADJ
fnp-3910	107	11	leukocyte	leukocyte	NOUN
fnp-3910	107	12	marker	marker	NOUN
fnp-3910	107	13	)	)	PUNCT
fnp-3910	107	14	antibody	antibody	NOUN
fnp-3910	107	15	was	be	AUX
fnp-3910	107	16	used	use	VERB
fnp-3910	107	17	to	to	PART
fnp-3910	107	18	exclude	exclude	VERB
fnp-3910	107	19	intravascular	intravascular	ADJ
fnp-3910	107	20	immune	immune	ADJ
fnp-3910	107	21	cells	cell	NOUN
fnp-3910	107	22	.	.	PUNCT
fnp-3910	108	1	comparing	compare	VERB
fnp-3910	108	2	scrna	scrna	NOUN
fnp-3910	108	3	-	-	PUNCT
fnp-3910	108	4	seq	seq	NOUN
fnp-3910	108	5	data	datum	NOUN
fnp-3910	108	6	from	from	ADP
fnp-3910	108	7	different	different	ADJ
fnp-3910	108	8	tissues	tissue	NOUN
fnp-3910	108	9	revealed	reveal	VERB
fnp-3910	108	10	that	that	SCONJ
fnp-3910	108	11	the	the	DET
fnp-3910	108	12	dura	dura	NOUN
fnp-3910	108	13	contained	contain	VERB
fnp-3910	108	14	a	a	DET
fnp-3910	108	15	large	large	ADJ
fnp-3910	108	16	cluster	cluster	NOUN
fnp-3910	108	17	of	of	ADP
fnp-3910	108	18	b	b	NOUN
fnp-3910	108	19	cells	cell	NOUN
fnp-3910	108	20	.	.	PUNCT
fnp-3910	109	1	these	these	DET
fnp-3910	109	2	dural	dural	ADJ
fnp-3910	109	3	b	b	PROPN
fnp-3910	109	4	cells	cell	NOUN
fnp-3910	109	5	were	be	AUX
fnp-3910	109	6	subclustered	subclustere	VERB
fnp-3910	109	7	into	into	ADP
fnp-3910	109	8	cxcr4high	cxcr4high	PROPN
fnp-3910	109	9	(	(	PUNCT
fnp-3910	109	10	signifying	signify	VERB
fnp-3910	109	11	immature	immature	ADJ
fnp-3910	109	12	bone	bone	NOUN
fnp-3910	109	13	marrow	marrow	NOUN
fnp-3910	109	14	b	b	PROPN
fnp-3910	109	15	cells	cell	NOUN
fnp-3910	109	16	)	)	PUNCT
fnp-3910	109	17	versus	versus	ADP
fnp-3910	109	18	ccl2highcxcl1/2highccl4highitgb2high	ccl2highcxcl1/2highccl4highitgb2high	PROPN
fnp-3910	109	19	(	(	PUNCT
fnp-3910	109	20	signifying	signify	VERB
fnp-3910	109	21	chemotactically	chemotactically	ADV
fnp-3910	109	22	active	active	ADJ
fnp-3910	109	23	b	b	NOUN
fnp-3910	109	24	cells	cell	NOUN
fnp-3910	109	25	)	)	PUNCT
fnp-3910	109	26	.	.	PUNCT
fnp-3910	110	1	using	use	VERB
fnp-3910	110	2	myelin	myelin	ADJ
fnp-3910	110	3	oligodendrocyte	oligodendrocyte	ADJ
fnp-3910	110	4	glycoprotein	glycoprotein	NOUN
fnp-3910	110	5	(	(	PUNCT
fnp-3910	110	6	mog)35–55	mog)35–55	NOUN
fnp-3910	110	7	peptide	peptide	NOUN
fnp-3910	110	8	-	-	PUNCT
fnp-3910	110	9	induced	induce	VERB
fnp-3910	110	10	experimental	experimental	ADJ
fnp-3910	110	11	autoimmune	autoimmune	ADJ
fnp-3910	110	12	encephalomyelitis	encephalomyelitis	NOUN
fnp-3910	110	13	(	(	PUNCT
fnp-3910	110	14	eae	eae	NOUN
fnp-3910	110	15	)	)	PUNCT
fnp-3910	110	16	models	model	NOUN
fnp-3910	110	17	of	of	ADP
fnp-3910	110	18	neuroinflammation	neuroinflammation	NOUN
fnp-3910	110	19	,	,	PUNCT
fnp-3910	110	20	the	the	DET
fnp-3910	110	21	authors	author	NOUN
fnp-3910	110	22	showed	show	VERB
fnp-3910	110	23	that	that	SCONJ
fnp-3910	110	24	inflammation	inflammation	NOUN
fnp-3910	110	25	drives	drive	VERB
fnp-3910	110	26	phenotypic	phenotypic	ADJ
fnp-3910	110	27	changes	change	NOUN
fnp-3910	110	28	of	of	ADP
fnp-3910	110	29	dural	dural	ADJ
fnp-3910	110	30	b	b	PROPN
fnp-3910	110	31	cells	cell	NOUN
fnp-3910	110	32	by	by	ADP
fnp-3910	110	33	favoring	favor	VERB
fnp-3910	110	34	class	class	NOUN
fnp-3910	110	35	-	-	PUNCT
fnp-3910	110	36	switched	switch	VERB
fnp-3910	110	37	plasma	plasma	NOUN
fnp-3910	110	38	cells	cell	NOUN
fnp-3910	110	39	with	with	ADP
fnp-3910	110	40	higher	high	ADJ
fnp-3910	110	41	expression	expression	NOUN
fnp-3910	110	42	of	of	ADP
fnp-3910	110	43	iga	iga	PROPN
fnp-3910	110	44	than	than	ADP
fnp-3910	110	45	igg	igg	PROPN
fnp-3910	110	46	.	.	PUNCT
fnp-3910	111	1	dural	dural	PROPN
fnp-3910	111	2	b	b	PROPN
fnp-3910	111	3	cells	cell	NOUN
fnp-3910	111	4	exhibited	exhibit	VERB
fnp-3910	111	5	higher	high	ADJ
fnp-3910	111	6	mhc	mhc	PROPN
fnp-3910	111	7	class	class	PROPN
fnp-3910	111	8	ii	ii	PROPN
fnp-3910	111	9	and	and	CCONJ
fnp-3910	111	10	other	other	ADJ
fnp-3910	111	11	markers	marker	NOUN
fnp-3910	111	12	,	,	PUNCT
fnp-3910	111	13	indicating	indicate	VERB
fnp-3910	111	14	an	an	DET
fnp-3910	111	15	increased	increased	ADJ
fnp-3910	111	16	antigen	antigen	NOUN
fnp-3910	111	17	-	-	PUNCT
fnp-3910	111	18	presenting	present	VERB
fnp-3910	111	19	capacity	capacity	NOUN
fnp-3910	111	20	under	under	ADP
fnp-3910	111	21	inflammatory	inflammatory	ADJ
fnp-3910	111	22	conditions	condition	NOUN
fnp-3910	111	23	.	.	PUNCT
fnp-3910	112	1	location	location	NOUN
fnp-3910	112	2	of	of	ADP
fnp-3910	112	3	meningeal	meningeal	ADJ
fnp-3910	112	4	b	b	PROPN
fnp-3910	112	5	cells	cell	NOUN
fnp-3910	112	6	under	under	ADP
fnp-3910	112	7	homeostatic	homeostatic	ADJ
fnp-3910	112	8	conditions	condition	NOUN
fnp-3910	112	9	was	be	AUX
fnp-3910	112	10	then	then	ADV
fnp-3910	112	11	investigated	investigate	VERB
fnp-3910	112	12	using	use	VERB
fnp-3910	112	13	immunofluorescence	immunofluorescence	NOUN
fnp-3910	112	14	of	of	ADP
fnp-3910	112	15	whole	whole	ADJ
fnp-3910	112	16	mount	mount	PROPN
fnp-3910	112	17	dura	dura	NOUN
fnp-3910	112	18	preparations	preparation	NOUN
fnp-3910	112	19	after	after	ADP
fnp-3910	112	20	intravenous	intravenous	ADJ
fnp-3910	112	21	injections	injection	NOUN
fnp-3910	112	22	with	with	ADP
fnp-3910	112	23	a	a	DET
fnp-3910	112	24	fluorophore	fluorophore	NOUN
fnp-3910	112	25	-	-	PUNCT
fnp-3910	112	26	labeled	label	VERB
fnp-3910	112	27	cd45	cd45	PROPN
fnp-3910	112	28	antibody	antibody	NOUN
fnp-3910	112	29	.	.	PUNCT
fnp-3910	113	1	results	result	NOUN
fnp-3910	113	2	showed	show	VERB
fnp-3910	113	3	that	that	SCONJ
fnp-3910	113	4	dural	dural	ADJ
fnp-3910	113	5	b	b	PROPN
fnp-3910	113	6	cells	cell	NOUN
fnp-3910	113	7	are	be	AUX
fnp-3910	113	8	located	locate	VERB
fnp-3910	113	9	both	both	CCONJ
fnp-3910	113	10	within	within	ADP
fnp-3910	113	11	and	and	CCONJ
fnp-3910	113	12	outside	outside	ADV
fnp-3910	113	13	of	of	ADP
fnp-3910	113	14	blood	blood	NOUN
fnp-3910	113	15	and	and	CCONJ
fnp-3910	113	16	lymphatic	lymphatic	ADJ
fnp-3910	113	17	vessels	vessel	NOUN
fnp-3910	113	18	,	,	PUNCT
fnp-3910	113	19	and	and	CCONJ
fnp-3910	113	20	interestingly	interestingly	ADV
fnp-3910	113	21	,	,	PUNCT
fnp-3910	113	22	the	the	DET
fnp-3910	113	23	extravascular	extravascular	ADJ
fnp-3910	113	24	b	b	PROPN
fnp-3910	113	25	cells	cell	NOUN
fnp-3910	113	26	were	be	AUX
fnp-3910	113	27	particularly	particularly	ADV
fnp-3910	113	28	abundant	abundant	ADJ
fnp-3910	113	29	along	along	ADP
fnp-3910	113	30	the	the	DET
fnp-3910	113	31	skull	skull	NOUN
fnp-3910	113	32	sutures	suture	NOUN
fnp-3910	113	33	.	.	PUNCT
fnp-3910	114	1	next	next	ADV
fnp-3910	114	2	,	,	PUNCT
fnp-3910	114	3	the	the	DET
fnp-3910	114	4	authors	author	NOUN
fnp-3910	114	5	confirmed	confirm	VERB
fnp-3910	114	6	the	the	DET
fnp-3910	114	7	presence	presence	NOUN
fnp-3910	114	8	of	of	ADP
fnp-3910	114	9	meningeal	meningeal	ADJ
fnp-3910	114	10	b	b	PROPN
fnp-3910	114	11	cells	cell	NOUN
fnp-3910	114	12	in	in	ADP
fnp-3910	114	13	human	human	ADJ
fnp-3910	114	14	autopsy	autopsy	ADJ
fnp-3910	114	15	samples	sample	NOUN
fnp-3910	114	16	using	use	VERB
fnp-3910	114	17	cd19+cd20+cd79a+	cd19+cd20+cd79a+	NOUN
fnp-3910	114	18	stainings	staining	NOUN
fnp-3910	114	19	,	,	PUNCT
fnp-3910	114	20	and	and	CCONJ
fnp-3910	114	21	found	find	VERB
fnp-3910	114	22	that	that	SCONJ
fnp-3910	114	23	human	human	ADJ
fnp-3910	114	24	dura	dura	NOUN
fnp-3910	114	25	also	also	ADV
fnp-3910	114	26	houses	house	VERB
fnp-3910	114	27	a	a	DET
fnp-3910	114	28	relevant	relevant	ADJ
fnp-3910	114	29	population	population	NOUN
fnp-3910	114	30	of	of	ADP
fnp-3910	114	31	b	b	NOUN
fnp-3910	114	32	cells	cell	NOUN
fnp-3910	114	33	.	.	PUNCT
fnp-3910	115	1	using	use	VERB
fnp-3910	115	2	parabiotic	parabiotic	ADJ
fnp-3910	115	3	mouse	mouse	NOUN
fnp-3910	115	4	models	model	NOUN
fnp-3910	115	5	with	with	ADP
fnp-3910	115	6	different	different	ADJ
fnp-3910	115	7	cd45	cd45	PROPN
fnp-3910	115	8	haplotypes	haplotype	NOUN
fnp-3910	115	9	,	,	PUNCT
fnp-3910	115	10	the	the	DET
fnp-3910	115	11	precursor	precursor	NOUN
fnp-3910	115	12	dural	dural	PROPN
fnp-3910	115	13	b	b	PROPN
fnp-3910	115	14	cells	cell	NOUN
fnp-3910	115	15	were	be	AUX
fnp-3910	115	16	shown	show	VERB
fnp-3910	115	17	to	to	PART
fnp-3910	115	18	be	be	AUX
fnp-3910	115	19	tissue	tissue	NOUN
fnp-3910	115	20	resident	resident	NOUN
fnp-3910	115	21	with	with	ADP
fnp-3910	115	22	capacity	capacity	NOUN
fnp-3910	115	23	for	for	ADP
fnp-3910	115	24	local	local	ADJ
fnp-3910	115	25	proliferation	proliferation	NOUN
fnp-3910	115	26	,	,	PUNCT
fnp-3910	115	27	and	and	CCONJ
fnp-3910	115	28	the	the	DET
fnp-3910	115	29	authors	author	NOUN
fnp-3910	115	30	claimed	claim	VERB
fnp-3910	115	31	their	their	PRON
fnp-3910	115	32	skull	skull	NOUN
fnp-3910	115	33	labeling	labeling	NOUN
fnp-3910	115	34	approach	approach	NOUN
fnp-3910	115	35	challenges	challenge	VERB
fnp-3910	115	36	the	the	DET
fnp-3910	115	37	presumptive	presumptive	ADJ
fnp-3910	115	38	skull	skull	NOUN
fnp-3910	115	39	-	-	PUNCT
fnp-3910	115	40	to	to	ADP
fnp-3910	115	41	-	-	PUNCT
fnp-3910	115	42	dura	dura	NOUN
fnp-3910	115	43	immune	immune	ADJ
fnp-3910	115	44	cell	cell	NOUN
fnp-3910	115	45	flux	flux	NOUN
fnp-3910	115	46	.	.	PUNCT
fnp-3910	116	1	this	this	DET
fnp-3910	116	2	study	study	NOUN
fnp-3910	116	3	provided	provide	VERB
fnp-3910	116	4	elegant	elegant	ADJ
fnp-3910	116	5	data	datum	NOUN
fnp-3910	116	6	regarding	regard	VERB
fnp-3910	116	7	the	the	DET
fnp-3910	116	8	presence	presence	NOUN
fnp-3910	116	9	of	of	ADP
fnp-3910	116	10	a	a	DET
fnp-3910	116	11	previously	previously	ADV
fnp-3910	116	12	-	-	PUNCT
fnp-3910	116	13	neglected	neglect	VERB
fnp-3910	116	14	,	,	PUNCT
fnp-3910	116	15	strategically	strategically	ADV
fnp-3910	116	16	-	-	PUNCT
fnp-3910	116	17	located	locate	VERB
fnp-3910	116	18	population	population	NOUN
fnp-3910	116	19	of	of	ADP
fnp-3910	116	20	meningeal	meningeal	ADJ
fnp-3910	116	21	b	b	PROPN
fnp-3910	116	22	cells	cell	NOUN
fnp-3910	116	23	with	with	ADP
fnp-3910	116	24	high	high	ADJ
fnp-3910	116	25	potency	potency	NOUN
fnp-3910	116	26	for	for	ADP
fnp-3910	116	27	antigen	antigen	NOUN
fnp-3910	116	28	-	-	PUNCT
fnp-3910	116	29	presentation	presentation	NOUN
fnp-3910	116	30	,	,	PUNCT
fnp-3910	116	31	chemotaxis	chemotaxis	ADJ
fnp-3910	116	32	,	,	PUNCT
fnp-3910	116	33	and	and	CCONJ
fnp-3910	116	34	regulation	regulation	NOUN
fnp-3910	116	35	of	of	ADP
fnp-3910	116	36	cns	cns	NOUN
fnp-3910	116	37	-	-	PUNCT
fnp-3910	116	38	antigen	antigen	NOUN
fnp-3910	116	39	-	-	PUNCT
fnp-3910	116	40	specific	specific	ADJ
fnp-3910	116	41	neuroinflammation	neuroinflammation	NOUN
fnp-3910	116	42	.	.	PUNCT
fnp-3910	117	1	topic	topic	NOUN
fnp-3910	117	2	6	6	NUM
fnp-3910	117	3	:	:	PUNCT
fnp-3910	117	4	skull	skull	NOUN
fnp-3910	117	5	and	and	CCONJ
fnp-3910	117	6	vertebral	vertebral	ADJ
fnp-3910	117	7	bone	bone	NOUN
fnp-3910	117	8	marrow	marrow	NOUN
fnp-3910	117	9	are	be	AUX
fnp-3910	117	10	myeloid	myeloid	ADJ
fnp-3910	117	11	cell	cell	NOUN
fnp-3910	117	12	reservoirs	reservoir	NOUN
fnp-3910	117	13	for	for	ADP
fnp-3910	117	14	the	the	DET
fnp-3910	117	15	meninges	meninge	NOUN
fnp-3910	117	16	and	and	CCONJ
fnp-3910	117	17	cns	cns	NOUN
fnp-3910	117	18	parenchyma	parenchyma	NOUN
fnp-3910	117	19	a	a	DET
fnp-3910	117	20	third	third	ADJ
fnp-3910	117	21	paper	paper	NOUN
fnp-3910	117	22	(	(	PUNCT
fnp-3910	117	23	8)	8)	NUM
fnp-3910	117	24	that	that	PRON
fnp-3910	117	25	integrates	integrate	NOUN
fnp-3910	117	26	well	well	ADV
fnp-3910	117	27	with	with	ADP
fnp-3910	117	28	the	the	DET
fnp-3910	117	29	theme	theme	NOUN
fnp-3910	117	30	of	of	ADP
fnp-3910	117	31	the	the	DET
fnp-3910	117	32	prior	prior	ADJ
fnp-3910	117	33	two	two	NUM
fnp-3910	117	34	,	,	PUNCT
fnp-3910	117	35	also	also	ADV
fnp-3910	117	36	examined	examine	VERB
fnp-3910	117	37	skull	skull	NOUN
fnp-3910	117	38	and	and	CCONJ
fnp-3910	117	39	vertebral	vertebral	ADJ
fnp-3910	117	40	bone	bone	NOUN
fnp-3910	117	41	marrow	marrow	NOUN
fnp-3910	117	42	,	,	PUNCT
fnp-3910	117	43	but	but	CCONJ
fnp-3910	117	44	this	this	PRON
fnp-3910	117	45	focused	focus	VERB
fnp-3910	117	46	on	on	ADP
fnp-3910	117	47	the	the	DET
fnp-3910	117	48	myeloid	myeloid	NOUN
fnp-3910	117	49	compartment	compartment	NOUN
fnp-3910	117	50	.	.	PUNCT
fnp-3910	118	1	meninges	meninge	NOUN
fnp-3910	118	2	as	as	SCONJ
fnp-3910	118	3	evidenced	evidence	VERB
fnp-3910	118	4	from	from	ADP
fnp-3910	118	5	this	this	DET
fnp-3910	118	6	triad	triad	NUM
fnp-3910	118	7	of	of	ADP
fnp-3910	118	8	papers	paper	NOUN
fnp-3910	118	9	,	,	PUNCT
fnp-3910	118	10	contain	contain	VERB
fnp-3910	118	11	a	a	DET
fnp-3910	118	12	large	large	ADJ
fnp-3910	118	13	pool	pool	NOUN
fnp-3910	118	14	of	of	ADP
fnp-3910	118	15	immune	immune	ADJ
fnp-3910	118	16	cells	cell	NOUN
fnp-3910	118	17	.	.	PUNCT
fnp-3910	119	1	however	however	ADV
fnp-3910	119	2	,	,	PUNCT
fnp-3910	119	3	unlike	unlike	ADP
fnp-3910	119	4	the	the	DET
fnp-3910	119	5	prior	prior	ADJ
fnp-3910	119	6	papers	paper	NOUN
fnp-3910	119	7	,	,	PUNCT
fnp-3910	119	8	this	this	DET
fnp-3910	119	9	paper	paper	NOUN
fnp-3910	119	10	focused	focus	VERB
fnp-3910	119	11	on	on	ADP
fnp-3910	119	12	innate	innate	ADJ
fnp-3910	119	13	immune	immune	ADJ
fnp-3910	119	14	cells	cell	NOUN
fnp-3910	119	15	rather	rather	ADV
fnp-3910	119	16	than	than	ADP
fnp-3910	119	17	adaptive	adaptive	ADJ
fnp-3910	119	18	b	b	NOUN
fnp-3910	119	19	cells	cell	NOUN
fnp-3910	119	20	.	.	PUNCT
fnp-3910	120	1	myeloid	myeloid	ADJ
fnp-3910	120	2	cells	cell	NOUN
fnp-3910	120	3	are	be	AUX
fnp-3910	120	4	some	some	PRON
fnp-3910	120	5	of	of	ADP
fnp-3910	120	6	the	the	DET
fnp-3910	120	7	earlies	earlie	NOUN
fnp-3910	120	8	responders	responder	NOUN
fnp-3910	120	9	to	to	ADP
fnp-3910	120	10	brain	brain	NOUN
fnp-3910	120	11	injury	injury	NOUN
fnp-3910	120	12	.	.	PUNCT
fnp-3910	121	1	it	it	PRON
fnp-3910	121	2	is	be	AUX
fnp-3910	121	3	well	well	ADV
fnp-3910	121	4	known	know	VERB
fnp-3910	121	5	that	that	SCONJ
fnp-3910	121	6	these	these	DET
fnp-3910	121	7	cells	cell	NOUN
fnp-3910	121	8	can	can	AUX
fnp-3910	121	9	migrate	migrate	VERB
fnp-3910	121	10	from	from	ADP
fnp-3910	121	11	the	the	DET
fnp-3910	121	12	periphery	periphery	NOUN
fnp-3910	121	13	to	to	PART
fnp-3910	121	14	invade	invade	VERB
fnp-3910	121	15	the	the	DET
fnp-3910	121	16	cns	cns	NOUN
fnp-3910	121	17	.	.	PUNCT
fnp-3910	122	1	this	this	DET
fnp-3910	122	2	paper	paper	NOUN
fnp-3910	122	3	shows	show	VERB
fnp-3910	122	4	that	that	SCONJ
fnp-3910	122	5	these	these	PRON
fnp-3910	122	6	are	be	AUX
fnp-3910	122	7	not	not	PART
fnp-3910	122	8	only	only	ADV
fnp-3910	122	9	“	"	PUNCT
fnp-3910	122	10	blood	blood	NOUN
fnp-3910	122	11	-	-	PUNCT
fnp-3910	122	12	derived	derive	VERB
fnp-3910	122	13	”	"	PUNCT
fnp-3910	122	14	but	but	CCONJ
fnp-3910	122	15	can	can	AUX
fnp-3910	122	16	also	also	ADV
fnp-3910	122	17	come	come	VERB
fnp-3910	122	18	into	into	ADP
fnp-3910	122	19	the	the	DET
fnp-3910	122	20	cns	cns	NOUN
fnp-3910	122	21	,	,	PUNCT
fnp-3910	122	22	rapidly	rapidly	ADV
fnp-3910	122	23	,	,	PUNCT
fnp-3910	122	24	from	from	ADP
fnp-3910	122	25	the	the	DET
fnp-3910	122	26	skull	skull	NOUN
fnp-3910	122	27	bone	bone	NOUN
fnp-3910	122	28	marrow	marrow	NOUN
fnp-3910	122	29	.	.	PUNCT
fnp-3910	123	1	the	the	DET
fnp-3910	123	2	perivascular	perivascular	ADJ
fnp-3910	123	3	spaces	space	NOUN
fnp-3910	123	4	and	and	CCONJ
fnp-3910	123	5	the	the	DET
fnp-3910	123	6	meningeal	meningeal	ADJ
fnp-3910	123	7	membranes	membrane	NOUN
fnp-3910	123	8	that	that	PRON
fnp-3910	123	9	cover	cover	VERB
fnp-3910	123	10	the	the	DET
fnp-3910	123	11	cns	cns	NOUN
fnp-3910	123	12	border	border	NOUN
fnp-3910	123	13	zones	zone	NOUN
fnp-3910	123	14	are	be	AUX
fnp-3910	123	15	also	also	ADV
fnp-3910	123	16	populated	populate	VERB
fnp-3910	123	17	by	by	ADP
fnp-3910	123	18	a	a	DET
fnp-3910	123	19	variety	variety	NOUN
fnp-3910	123	20	of	of	ADP
fnp-3910	123	21	myeloid	myeloid	ADJ
fnp-3910	123	22	cells	cell	NOUN
fnp-3910	123	23	.	.	PUNCT
fnp-3910	124	1	in	in	ADP
fnp-3910	124	2	this	this	DET
fnp-3910	124	3	work	work	NOUN
fnp-3910	124	4	,	,	PUNCT
fnp-3910	124	5	cugarra	cugarra	NOUN
fnp-3910	124	6	and	and	CCONJ
fnp-3910	124	7	others	other	NOUN
fnp-3910	124	8	show	show	VERB
fnp-3910	124	9	that	that	SCONJ
fnp-3910	124	10	cns	cns	NOUN
fnp-3910	124	11	-	-	PUNCT
fnp-3910	124	12	associated	associate	VERB
fnp-3910	124	13	bone	bone	NOUN
fnp-3910	124	14	marrow	marrow	NOUN
fnp-3910	124	15	niches	niche	NOUN
fnp-3910	124	16	in	in	ADP
fnp-3910	124	17	the	the	DET
fnp-3910	124	18	skull	skull	NOUN
fnp-3910	124	19	and	and	CCONJ
fnp-3910	124	20	vertebrae	vertebrae	NOUN
fnp-3910	124	21	are	be	AUX
fnp-3910	124	22	also	also	ADV
fnp-3910	124	23	myeloid	myeloid	ADJ
fnp-3910	124	24	reservoirs	reservoir	NOUN
fnp-3910	124	25	for	for	ADP
fnp-3910	124	26	the	the	DET
fnp-3910	124	27	meninges	meninge	NOUN
fnp-3910	124	28	and	and	CCONJ
fnp-3910	124	29	cns	cns	NOUN
fnp-3910	124	30	parenchyma	parenchyma	NOUN
fnp-3910	124	31	.	.	PUNCT
fnp-3910	125	1	under	under	ADP
fnp-3910	125	2	homeostasis	homeostasis	NOUN
fnp-3910	125	3	,	,	PUNCT
fnp-3910	125	4	these	these	DET
fnp-3910	125	5	bone	bone	NOUN
fnp-3910	125	6	marrow	marrow	NOUN
fnp-3910	125	7	pools	pool	NOUN
fnp-3910	125	8	supply	supply	VERB
fnp-3910	125	9	the	the	DET
fnp-3910	125	10	brain	brain	NOUN
fnp-3910	125	11	and	and	CCONJ
fnp-3910	125	12	spinal	spinal	ADJ
fnp-3910	125	13	dural	dural	ADJ
fnp-3910	125	14	meninges	meninge	NOUN
fnp-3910	125	15	with	with	ADP
fnp-3910	125	16	monocytes	monocyte	NOUN
fnp-3910	125	17	and	and	CCONJ
fnp-3910	125	18	neutrophils	neutrophil	NOUN
fnp-3910	125	19	via	via	ADP
fnp-3910	125	20	direct	direct	ADJ
fnp-3910	125	21	dural	dural	ADJ
fnp-3910	125	22	-	-	PUNCT
fnp-3910	125	23	bone	bone	NOUN
fnp-3910	125	24	marrow	marrow	NOUN
fnp-3910	125	25	connections	connection	NOUN
fnp-3910	125	26	.	.	PUNCT
fnp-3910	126	1	using	use	VERB
fnp-3910	126	2	elegant	elegant	ADJ
fnp-3910	126	3	fate	fate	NOUN
fnp-3910	126	4	mapping	mapping	NOUN
fnp-3910	126	5	,	,	PUNCT
fnp-3910	126	6	dural	dural	ADJ
fnp-3910	126	7	ly6c+	ly6c+	PROPN
fnp-3910	126	8	monocytes	monocyte	NOUN
fnp-3910	126	9	and	and	CCONJ
fnp-3910	126	10	neutrophils	neutrophil	NOUN
fnp-3910	126	11	were	be	AUX
fnp-3910	126	12	suspected	suspect	VERB
fnp-3910	126	13	to	to	PART
fnp-3910	126	14	be	be	AUX
fnp-3910	126	15	from	from	ADP
fnp-3910	126	16	a	a	DET
fnp-3910	126	17	local	local	ADJ
fnp-3910	126	18	source	source	NOUN
fnp-3910	126	19	rather	rather	ADV
fnp-3910	126	20	than	than	ADP
fnp-3910	126	21	the	the	DET
fnp-3910	126	22	blood	blood	NOUN
fnp-3910	126	23	.	.	PUNCT
fnp-3910	127	1	a	a	DET
fnp-3910	127	2	calvaria	calvaria	NOUN
fnp-3910	127	3	bone	bone	NOUN
fnp-3910	127	4	-	-	PUNCT
fnp-3910	127	5	flap	flap	NOUN
fnp-3910	127	6	with	with	ADP
fnp-3910	127	7	accompanying	accompany	VERB
fnp-3910	127	8	bone	bone	NOUN
fnp-3910	127	9	marrow	marrow	NOUN
fnp-3910	127	10	reservoir	reservoir	NOUN
fnp-3910	127	11	from	from	ADP
fnp-3910	127	12	gfp+	gfp+	PROPN
fnp-3910	127	13	mice	mouse	NOUN
fnp-3910	127	14	was	be	AUX
fnp-3910	127	15	transplanted	transplant	VERB
fnp-3910	127	16	into	into	ADP
fnp-3910	127	17	wild	wild	ADJ
fnp-3910	127	18	-	-	PUNCT
fnp-3910	127	19	type	type	NOUN
fnp-3910	127	20	(	(	PUNCT
fnp-3910	127	21	wt	wt	NOUN
fnp-3910	127	22	)	)	PUNCT
fnp-3910	127	23	mice	mouse	NOUN
fnp-3910	127	24	with	with	ADP
fnp-3910	127	25	an	an	DET
fnp-3910	127	26	intact	intact	ADJ
fnp-3910	127	27	dura	dura	NOUN
fnp-3910	127	28	.	.	PUNCT
fnp-3910	128	1	gfp+	gfp+	PROPN
fnp-3910	128	2	cells	cell	NOUN
fnp-3910	128	3	including	include	VERB
fnp-3910	128	4	ccr2	ccr2	PROPN
fnp-3910	128	5	+	+	CCONJ
fnp-3910	128	6	monocytes	monocyte	NOUN
fnp-3910	128	7	,	,	PUNCT
fnp-3910	128	8	iba1	iba1	PROPN
fnp-3910	128	9	+	+	CCONJ
fnp-3910	128	10	macrophages	macrophage	NOUN
fnp-3910	128	11	,	,	PUNCT
fnp-3910	128	12	and	and	CCONJ
fnp-3910	128	13	cd31	cd31	PROPN
fnp-3910	128	14	+	+	CCONJ
fnp-3910	128	15	vasculature	vasculature	NOUN
fnp-3910	128	16	was	be	AUX
fnp-3910	128	17	seen	see	VERB
fnp-3910	128	18	in	in	ADP
fnp-3910	128	19	the	the	DET
fnp-3910	128	20	underlying	underlie	VERB
fnp-3910	128	21	dura	dura	NOUN
fnp-3910	128	22	of	of	ADP
fnp-3910	128	23	the	the	DET
fnp-3910	128	24	transplanted	transplanted	ADJ
fnp-3910	128	25	calvaria	calvaria	NOUN
fnp-3910	128	26	flap	flap	NOUN
fnp-3910	128	27	.	.	PUNCT
fnp-3910	129	1	thus	thus	ADV
fnp-3910	129	2	,	,	PUNCT
fnp-3910	129	3	under	under	ADP
fnp-3910	129	4	homeostatic	homeostatic	ADJ
fnp-3910	129	5	conditions	condition	NOUN
fnp-3910	129	6	,	,	PUNCT
fnp-3910	129	7	the	the	DET
fnp-3910	129	8	myeloid	myeloid	ADJ
fnp-3910	129	9	niche	niche	NOUN
fnp-3910	129	10	distributed	distribute	VERB
fnp-3910	129	11	along	along	ADP
fnp-3910	129	12	the	the	DET
fnp-3910	129	13	brain	brain	NOUN
fnp-3910	129	14	borders	border	NOUN
fnp-3910	129	15	receives	receive	VERB
fnp-3910	129	16	a	a	DET
fnp-3910	129	17	substantial	substantial	ADJ
fnp-3910	129	18	input	input	NOUN
fnp-3910	129	19	from	from	ADP
fnp-3910	129	20	the	the	DET
fnp-3910	129	21	skull	skull	NOUN
fnp-3910	129	22	bone	bone	NOUN
fnp-3910	129	23	marrow	marrow	NOUN
fnp-3910	129	24	,	,	PUNCT
fnp-3910	129	25	which	which	PRON
fnp-3910	129	26	appears	appear	VERB
fnp-3910	129	27	to	to	PART
fnp-3910	129	28	act	act	VERB
fnp-3910	129	29	as	as	ADP
fnp-3910	129	30	a	a	DET
fnp-3910	129	31	critical	critical	ADJ
fnp-3910	129	32	dispenser	dispenser	NOUN
fnp-3910	129	33	of	of	ADP
fnp-3910	129	34	myeloid	myeloid	ADJ
fnp-3910	129	35	cells	cell	NOUN
fnp-3910	129	36	.	.	PUNCT
fnp-3910	130	1	this	this	PRON
fnp-3910	130	2	provides	provide	VERB
fnp-3910	130	3	an	an	DET
fnp-3910	130	4	example	example	NOUN
fnp-3910	130	5	of	of	ADP
fnp-3910	130	6	a	a	DET
fnp-3910	130	7	healthy	healthy	ADJ
fnp-3910	130	8	tissue	tissue	NOUN
fnp-3910	130	9	hosting	host	VERB
fnp-3910	130	10	myeloid	myeloid	ADJ
fnp-3910	130	11	cells	cell	NOUN
fnp-3910	130	12	that	that	PRON
fnp-3910	130	13	are	be	AUX
fnp-3910	130	14	continuously	continuously	ADV
fnp-3910	130	15	replenished	replenish	VERB
fnp-3910	130	16	by	by	ADP
fnp-3910	130	17	a	a	DET
fnp-3910	130	18	source	source	NOUN
fnp-3910	130	19	that	that	PRON
fnp-3910	130	20	does	do	AUX
fnp-3910	130	21	not	not	PART
fnp-3910	130	22	use	use	VERB
fnp-3910	130	23	blood	blood	NOUN
fnp-3910	130	24	as	as	ADP
fnp-3910	130	25	a	a	DET
fnp-3910	130	26	major	major	ADJ
fnp-3910	130	27	route	route	NOUN
fnp-3910	130	28	.	.	PUNCT
fnp-3910	131	1	the	the	DET
fnp-3910	131	2	authors	author	NOUN
fnp-3910	131	3	then	then	ADV
fnp-3910	131	4	went	go	VERB
fnp-3910	131	5	one	one	NUM
fnp-3910	131	6	step	step	NOUN
fnp-3910	131	7	further	far	ADV
fnp-3910	131	8	to	to	PART
fnp-3910	131	9	determine	determine	VERB
fnp-3910	131	10	if	if	SCONJ
fnp-3910	131	11	these	these	DET
fnp-3910	131	12	cells	cell	NOUN
fnp-3910	131	13	were	be	AUX
fnp-3910	131	14	involved	involve	VERB
fnp-3910	131	15	in	in	ADP
fnp-3910	131	16	an	an	DET
fnp-3910	131	17	early	early	ADJ
fnp-3910	131	18	response	response	NOUN
fnp-3910	131	19	to	to	ADP
fnp-3910	131	20	injury	injury	NOUN
fnp-3910	131	21	using	use	VERB
fnp-3910	131	22	parabiotic	parabiotic	ADJ
fnp-3910	131	23	models	model	NOUN
fnp-3910	131	24	in	in	ADP
fnp-3910	131	25	three	three	NUM
fnp-3910	131	26	injury	injury	NOUN
fnp-3910	131	27	paradigms	paradigm	NOUN
fnp-3910	131	28	,	,	PUNCT
fnp-3910	131	29	experimental	experimental	ADJ
fnp-3910	131	30	autoimmune	autoimmune	ADJ
fnp-3910	131	31	encephalitis	encephalitis	NOUN
fnp-3910	131	32	,	,	PUNCT
fnp-3910	131	33	spinal	spinal	ADJ
fnp-3910	131	34	cord	cord	NOUN
fnp-3910	131	35	injury	injury	NOUN
fnp-3910	131	36	,	,	PUNCT
fnp-3910	131	37	and	and	CCONJ
fnp-3910	131	38	optic	optic	ADJ
fnp-3910	131	39	nerve	nerve	NOUN
fnp-3910	131	40	crush	crush	NOUN
fnp-3910	131	41	.	.	PUNCT
fnp-3910	132	1	after	after	ADP
fnp-3910	132	2	injury	injury	NOUN
fnp-3910	132	3	and	and	CCONJ
fnp-3910	132	4	in	in	ADP
fnp-3910	132	5	neuroinflammatory	neuroinflammatory	ADJ
fnp-3910	132	6	diseases	disease	NOUN
fnp-3910	132	7	,	,	PUNCT
fnp-3910	132	8	the	the	DET
fnp-3910	132	9	authors	author	NOUN
fnp-3910	132	10	found	find	VERB
fnp-3910	132	11	that	that	SCONJ
fnp-3910	132	12	these	these	DET
fnp-3910	132	13	cells	cell	NOUN
fnp-3910	132	14	can	can	AUX
fnp-3910	132	15	mobilize	mobilize	VERB
fnp-3910	132	16	to	to	PART
fnp-3910	132	17	infiltrate	infiltrate	VERB
fnp-3910	132	18	the	the	DET
fnp-3910	132	19	cns	cns	NOUN
fnp-3910	132	20	parenchyma	parenchyma	NOUN
fnp-3910	132	21	,	,	PUNCT
fnp-3910	132	22	and	and	CCONJ
fnp-3910	132	23	display	display	VERB
fnp-3910	132	24	distinct	distinct	ADJ
fnp-3910	132	25	phenotypes	phenotype	NOUN
fnp-3910	132	26	from	from	ADP
fnp-3910	132	27	their	their	PRON
fnp-3910	132	28	blood	blood	NOUN
fnp-3910	132	29	-	-	PUNCT
fnp-3910	132	30	derived	derive	VERB
fnp-3910	132	31	counterparts	counterpart	NOUN
fnp-3910	132	32	.	.	PUNCT
fnp-3910	133	1	cns	cns	NOUN
fnp-3910	133	2	-	-	PUNCT
fnp-3910	133	3	infiltrating	infiltrate	VERB
fnp-3910	133	4	ly6c+	ly6c+	PROPN
fnp-3910	133	5	monocytes	monocyte	VERB
fnp-3910	133	6	(	(	PUNCT
fnp-3910	133	7	but	but	CCONJ
fnp-3910	133	8	not	not	PART
fnp-3910	133	9	neutrophils	neutrophil	NOUN
fnp-3910	133	10	,	,	PUNCT
fnp-3910	133	11	cd4	cd4	PROPN
fnp-3910	133	12	t	t	NOUN
fnp-3910	133	13	cells	cell	NOUN
fnp-3910	133	14	,	,	PUNCT
fnp-3910	133	15	or	or	CCONJ
fnp-3910	133	16	ly6c−	ly6c−	VERB
fnp-3910	133	17	monocytes	monocyte	NOUN
fnp-3910	133	18	)	)	PUNCT
fnp-3910	133	19	were	be	AUX
fnp-3910	133	20	supplied	supply	VERB
fnp-3910	133	21	not	not	PART
fnp-3910	133	22	from	from	ADP
fnp-3910	133	23	the	the	DET
fnp-3910	133	24	blood	blood	NOUN
fnp-3910	133	25	,	,	PUNCT
fnp-3910	133	26	but	but	CCONJ
fnp-3910	133	27	by	by	ADP
fnp-3910	133	28	adjacent	adjacent	ADJ
fnp-3910	133	29	skull	skull	NOUN
fnp-3910	133	30	and	and	CCONJ
fnp-3910	133	31	vertebral	vertebral	ADJ
fnp-3910	133	32	bone	bone	NOUN
fnp-3910	133	33	marrow	marrow	NOUN
fnp-3910	133	34	.	.	PUNCT
fnp-3910	134	1	it	it	PRON
fnp-3910	134	2	is	be	AUX
fnp-3910	134	3	becoming	become	VERB
fnp-3910	134	4	increasingly	increasingly	ADV
fnp-3910	134	5	clear	clear	ADJ
fnp-3910	134	6	that	that	SCONJ
fnp-3910	134	7	under	under	ADP
fnp-3910	134	8	pathological	pathological	ADJ
fnp-3910	134	9	conditions	condition	NOUN
fnp-3910	134	10	,	,	PUNCT
fnp-3910	134	11	cns	cns	NOUN
fnp-3910	134	12	-	-	PUNCT
fnp-3910	134	13	infiltrating	infiltrating	ADJ
fnp-3910	134	14	myeloid	myeloid	ADJ
fnp-3910	134	15	cells	cell	NOUN
fnp-3910	134	16	can	can	AUX
fnp-3910	134	17	originate	originate	VERB
fnp-3910	134	18	from	from	ADP
fnp-3910	134	19	brain	brain	NOUN
fnp-3910	134	20	borders	border	NOUN
fnp-3910	134	21	and	and	CCONJ
fnp-3910	134	22	display	display	VERB
fnp-3910	134	23	transcriptional	transcriptional	NOUN
fnp-3910	134	24	signatures	signature	NOUN
fnp-3910	134	25	distinct	distinct	ADJ
fnp-3910	134	26	from	from	ADP
fnp-3910	134	27	their	their	PRON
fnp-3910	134	28	blood	blood	NOUN
fnp-3910	134	29	-	-	PUNCT
fnp-3910	134	30	derived	derive	VERB
fnp-3910	134	31	counterparts	counterpart	NOUN
fnp-3910	134	32	.	.	PUNCT
fnp-3910	135	1	these	these	DET
fnp-3910	135	2	myeloid	myeloid	ADJ
fnp-3910	135	3	cells	cell	NOUN
fnp-3910	135	4	from	from	ADP
fnp-3910	135	5	bone	bone	NOUN
fnp-3910	135	6	-	-	PUNCT
fnp-3910	135	7	marrow	marrow	NOUN
fnp-3910	135	8	niches	niche	NOUN
fnp-3910	135	9	in	in	ADP
fnp-3910	135	10	close	close	ADJ
fnp-3910	135	11	proximity	proximity	NOUN
fnp-3910	135	12	to	to	ADP
fnp-3910	135	13	the	the	DET
fnp-3910	135	14	brain	brain	NOUN
fnp-3910	135	15	can	can	AUX
fnp-3910	135	16	supply	supply	VERB
fnp-3910	135	17	innate	innate	ADJ
fnp-3910	135	18	immune	immune	ADJ
fnp-3910	135	19	cells	cell	NOUN
fnp-3910	135	20	under	under	ADP
fnp-3910	135	21	both	both	CCONJ
fnp-3910	135	22	homeostatic	homeostatic	ADJ
fnp-3910	135	23	and	and	CCONJ
fnp-3910	135	24	pathological	pathological	ADJ
fnp-3910	135	25	conditions	condition	NOUN
fnp-3910	135	26	.	.	PUNCT
fnp-3910	136	1	topic	topic	NOUN
fnp-3910	136	2	7	7	NUM
fnp-3910	136	3	:	:	PUNCT
fnp-3910	136	4	microglia	microglia	NOUN
fnp-3910	136	5	contribute	contribute	NOUN
fnp-3910	136	6	to	to	ADP
fnp-3910	136	7	the	the	DET
fnp-3910	136	8	propagation	propagation	NOUN
fnp-3910	136	9	of	of	ADP
fnp-3910	136	10	aβ	aβ	PRON
fnp-3910	136	11	into	into	ADP
fnp-3910	136	12	unaffected	unaffected	ADJ
fnp-3910	136	13	brain	brain	NOUN
fnp-3910	136	14	tissue	tissue	NOUN
fnp-3910	136	15	this	this	DET
fnp-3910	136	16	very	very	ADV
fnp-3910	136	17	recent	recent	ADJ
fnp-3910	136	18	study	study	NOUN
fnp-3910	136	19	revealed	reveal	VERB
fnp-3910	136	20	that	that	SCONJ
fnp-3910	136	21	microglia	microglia	NOUN
fnp-3910	136	22	may	may	AUX
fnp-3910	136	23	act	act	VERB
fnp-3910	136	24	as	as	ADP
fnp-3910	136	25	aβ	aβ	DET
fnp-3910	136	26	carriers	carrier	NOUN
fnp-3910	136	27	in	in	ADP
fnp-3910	136	28	the	the	DET
fnp-3910	136	29	brain	brain	NOUN
fnp-3910	136	30	of	of	ADP
fnp-3910	136	31	alzheimer	alzheimer	PROPN
fnp-3910	136	32	’s	’s	PART
fnp-3910	136	33	disease	disease	NOUN
fnp-3910	136	34	(	(	PUNCT
fnp-3910	136	35	ad	ad	NOUN
fnp-3910	136	36	)	)	PUNCT
fnp-3910	136	37	model	model	NOUN
fnp-3910	136	38	mice	mouse	NOUN
fnp-3910	136	39	(	(	PUNCT
fnp-3910	136	40	9	9	NUM
fnp-3910	136	41	)	)	PUNCT
fnp-3910	136	42	.	.	PUNCT
fnp-3910	137	1	d’errico	d’errico	NOUN
fnp-3910	137	2	and	and	CCONJ
fnp-3910	137	3	colleagues	colleague	NOUN
fnp-3910	137	4	transplanted	transplant	VERB
fnp-3910	137	5	embryonic	embryonic	ADJ
fnp-3910	137	6	neuronal	neuronal	ADJ
fnp-3910	137	7	cells	cell	NOUN
fnp-3910	137	8	from	from	ADP
fnp-3910	137	9	wt	wt	DET
fnp-3910	137	10	mice	mouse	NOUN
fnp-3910	137	11	into	into	ADP
fnp-3910	137	12	the	the	DET
fnp-3910	137	13	neocortex	neocortex	NOUN
fnp-3910	137	14	of	of	ADP
fnp-3910	137	15	pre	pre	ADJ
fnp-3910	137	16	-	-	ADJ
fnp-3910	137	17	symptomatic	symptomatic	ADJ
fnp-3910	137	18	5xfad	5xfad	NUM
fnp-3910	137	19	transgenic	transgenic	NOUN
fnp-3910	137	20	mice	mouse	NOUN
fnp-3910	137	21	,	,	PUNCT
fnp-3910	137	22	a	a	DET
fnp-3910	137	23	mouse	mouse	NOUN
fnp-3910	137	24	model	model	NOUN
fnp-3910	137	25	recapitulating	recapitulate	VERB
fnp-3910	137	26	ad	ad	NOUN
fnp-3910	137	27	-	-	PUNCT
fnp-3910	137	28	related	relate	VERB
fnp-3910	137	29	pathology	pathology	NOUN
fnp-3910	137	30	.	.	PUNCT
fnp-3910	138	1	interestingly	interestingly	ADV
fnp-3910	138	2	,	,	PUNCT
fnp-3910	138	3	they	they	PRON
fnp-3910	138	4	found	find	VERB
fnp-3910	138	5	that	that	SCONJ
fnp-3910	138	6	aβ	aβ	PRON
fnp-3910	138	7	plaques	plaque	NOUN
fnp-3910	138	8	developed	develop	VERB
fnp-3910	138	9	as	as	ADV
fnp-3910	138	10	early	early	ADV
fnp-3910	138	11	as	as	ADP
fnp-3910	138	12	4	4	NUM
fnp-3910	138	13	weeks	week	NOUN
fnp-3910	138	14	within	within	ADP
fnp-3910	138	15	the	the	DET
fnp-3910	138	16	grafted	graft	VERB
fnp-3910	138	17	neuronal	neuronal	ADJ
fnp-3910	138	18	cells	cell	NOUN
fnp-3910	138	19	and	and	CCONJ
fnp-3910	138	20	continually	continually	ADV
fnp-3910	138	21	increase	increase	VERB
fnp-3910	138	22	over	over	ADP
fnp-3910	138	23	time	time	NOUN
fnp-3910	138	24	.	.	PUNCT
fnp-3910	139	1	they	they	PRON
fnp-3910	139	2	confirmed	confirm	VERB
fnp-3910	139	3	that	that	SCONJ
fnp-3910	139	4	this	this	PRON
fnp-3910	139	5	was	be	AUX
fnp-3910	139	6	not	not	PART
fnp-3910	139	7	due	due	ADJ
fnp-3910	139	8	to	to	ADP
fnp-3910	139	9	anterograde	anterograde	ADJ
fnp-3910	139	10	transport	transport	NOUN
fnp-3910	139	11	,	,	PUNCT
fnp-3910	139	12	as	as	SCONJ
fnp-3910	139	13	very	very	ADV
fnp-3910	139	14	few	few	ADJ
fnp-3910	139	15	host	host	NOUN
fnp-3910	139	16	processes	process	NOUN
fnp-3910	139	17	entered	enter	VERB
fnp-3910	139	18	the	the	DET
fnp-3910	139	19	graft	graft	NOUN
fnp-3910	139	20	using	use	VERB
fnp-3910	139	21	thy1	thy1	PROPN
fnp-3910	139	22	-	-	PUNCT
fnp-3910	139	23	gfp/5xfad	gfp/5xfad	PROPN
fnp-3910	139	24	mice	mouse	NOUN
fnp-3910	139	25	,	,	PUNCT
fnp-3910	139	26	confirming	confirm	VERB
fnp-3910	139	27	that	that	SCONJ
fnp-3910	139	28	the	the	DET
fnp-3910	139	29	spread	spread	NOUN
fnp-3910	139	30	of	of	ADP
fnp-3910	139	31	aβ	aβ	NOUN
fnp-3910	139	32	is	be	AUX
fnp-3910	139	33	independent	independent	ADJ
fnp-3910	139	34	of	of	ADP
fnp-3910	139	35	axonal	axonal	ADJ
fnp-3910	139	36	transport	transport	NOUN
fnp-3910	139	37	.	.	PUNCT
fnp-3910	140	1	the	the	DET
fnp-3910	140	2	greatest	great	ADJ
fnp-3910	140	3	amyloid	amyloid	NOUN
fnp-3910	140	4	accumulation	accumulation	NOUN
fnp-3910	140	5	was	be	AUX
fnp-3910	140	6	along	along	ADP
fnp-3910	140	7	the	the	DET
fnp-3910	140	8	graft	graft	NOUN
fnp-3910	140	9	border	border	NOUN
fnp-3910	140	10	,	,	PUNCT
fnp-3910	140	11	an	an	DET
fnp-3910	140	12	area	area	NOUN
fnp-3910	140	13	with	with	ADP
fnp-3910	140	14	higher	high	ADJ
fnp-3910	140	15	microglia	microglia	ADJ
fnp-3910	140	16	density	density	NOUN
fnp-3910	140	17	.	.	PUNCT
fnp-3910	141	1	therefore	therefore	ADV
fnp-3910	141	2	,	,	PUNCT
fnp-3910	141	3	the	the	DET
fnp-3910	141	4	authors	author	NOUN
fnp-3910	141	5	next	next	ADV
fnp-3910	141	6	investigated	investigate	VERB
fnp-3910	141	7	whether	whether	SCONJ
fnp-3910	141	8	host	host	NOUN
fnp-3910	141	9	microglia	microglia	NOUN
fnp-3910	141	10	are	be	AUX
fnp-3910	141	11	able	able	ADJ
fnp-3910	141	12	to	to	PART
fnp-3910	141	13	invade	invade	VERB
fnp-3910	141	14	the	the	DET
fnp-3910	141	15	wt	wt	NOUN
fnp-3910	141	16	graft	graft	NOUN
fnp-3910	141	17	using	use	VERB
fnp-3910	141	18	cx3cr1+/−/5xfad	cx3cr1+/−/5xfad	NOUN
fnp-3910	141	19	mice	mouse	NOUN
fnp-3910	141	20	.	.	PUNCT
fnp-3910	142	1	even	even	ADV
fnp-3910	142	2	as	as	ADV
fnp-3910	142	3	early	early	ADJ
fnp-3910	142	4	as	as	ADP
fnp-3910	142	5	2	2	NUM
fnp-3910	142	6	weeks	week	NOUN
fnp-3910	142	7	after	after	ADP
fnp-3910	142	8	transplantation	transplantation	NOUN
fnp-3910	142	9	,	,	PUNCT
fnp-3910	142	10	migration	migration	NOUN
fnp-3910	142	11	of	of	ADP
fnp-3910	142	12	host	host	NOUN
fnp-3910	142	13	cx3cr1	cx3cr1	NOUN
fnp-3910	142	14	+	+	X
fnp-3910	142	15	microglia	microglia	ADJ
fnp-3910	142	16	from	from	ADP
fnp-3910	142	17	cx3cr1+/-/5xfad	cx3cr1+/-/5xfad	NOUN
fnp-3910	142	18	mice	mouse	NOUN
fnp-3910	142	19	was	be	AUX
fnp-3910	142	20	evident	evident	ADJ
fnp-3910	142	21	within	within	ADP
fnp-3910	142	22	the	the	DET
fnp-3910	142	23	wt	wt	NOUN
fnp-3910	142	24	graft	graft	NOUN
fnp-3910	142	25	,	,	PUNCT
fnp-3910	142	26	indicating	indicate	VERB
fnp-3910	142	27	the	the	DET
fnp-3910	142	28	ability	ability	NOUN
fnp-3910	142	29	of	of	ADP
fnp-3910	142	30	microglia	microglia	NOUN
fnp-3910	142	31	to	to	PART
fnp-3910	142	32	act	act	VERB
fnp-3910	142	33	as	as	ADP
fnp-3910	142	34	an	an	DET
fnp-3910	142	35	aβ	aβ	NOUN
fnp-3910	142	36	carrier	carrier	NOUN
fnp-3910	142	37	leading	lead	VERB
fnp-3910	142	38	to	to	ADP
fnp-3910	142	39	graft	graft	NOUN
fnp-3910	142	40	invasion	invasion	NOUN
fnp-3910	142	41	.	.	PUNCT
fnp-3910	143	1	using	use	VERB
fnp-3910	143	2	a	a	DET
fnp-3910	143	3	variety	variety	NOUN
fnp-3910	143	4	of	of	ADP
fnp-3910	143	5	methods	method	NOUN
fnp-3910	143	6	,	,	PUNCT
fnp-3910	143	7	the	the	DET
fnp-3910	143	8	authors	author	NOUN
fnp-3910	143	9	confirmed	confirm	VERB
fnp-3910	143	10	that	that	SCONJ
fnp-3910	143	11	the	the	DET
fnp-3910	143	12	microglia	microglia	NOUN
fnp-3910	143	13	were	be	AUX
fnp-3910	143	14	not	not	PART
fnp-3910	143	15	host	host	NOUN
fnp-3910	143	16	derived	derive	VERB
fnp-3910	143	17	,	,	PUNCT
fnp-3910	143	18	or	or	CCONJ
fnp-3910	143	19	peripheral	peripheral	ADJ
fnp-3910	143	20	infiltrating	infiltrating	ADJ
fnp-3910	143	21	monocytes	monocyte	NOUN
fnp-3910	143	22	.	.	PUNCT
fnp-3910	144	1	they	they	PRON
fnp-3910	144	2	also	also	ADV
fnp-3910	144	3	confirmed	confirm	VERB
fnp-3910	144	4	using	use	VERB
fnp-3910	144	5	both	both	PRON
fnp-3910	144	6	in	in	ADP
fnp-3910	144	7	vitro	vitro	X
fnp-3910	144	8	and	and	CCONJ
fnp-3910	144	9	in	in	ADP
fnp-3910	144	10	vivo	vivo	NOUN
fnp-3910	144	11	models	model	NOUN
fnp-3910	144	12	that	that	PRON
fnp-3910	144	13	a	a	DET
fnp-3910	144	14	decline	decline	NOUN
fnp-3910	144	15	in	in	ADP
fnp-3910	144	16	microglial	microglial	ADJ
fnp-3910	144	17	phagocytosis	phagocytosis	NOUN
fnp-3910	144	18	of	of	ADP
fnp-3910	144	19	aβ	aβ	PRON
fnp-3910	144	20	occurs	occur	VERB
fnp-3910	144	21	in	in	ADP
fnp-3910	144	22	both	both	CCONJ
fnp-3910	144	23	old	old	ADJ
fnp-3910	144	24	wt	wt	NOUN
fnp-3910	144	25	and	and	CCONJ
fnp-3910	144	26	5xfad	5xfad	NUM
fnp-3910	144	27	mice	mouse	NOUN
fnp-3910	144	28	.	.	PUNCT
fnp-3910	145	1	several	several	ADJ
fnp-3910	145	2	additional	additional	ADJ
fnp-3910	145	3	models	model	NOUN
fnp-3910	145	4	including	include	VERB
fnp-3910	145	5	aged	age	VERB
fnp-3910	145	6	5xfad	5xfad	NUM
fnp-3910	145	7	mice	mouse	NOUN
fnp-3910	145	8	(	(	PUNCT
fnp-3910	145	9	with	with	ADP
fnp-3910	145	10	less	less	ADV
fnp-3910	145	11	microglial	microglial	ADJ
fnp-3910	145	12	phagocytic	phagocytic	ADJ
fnp-3910	145	13	activity	activity	NOUN
fnp-3910	145	14	)	)	PUNCT
fnp-3910	145	15	,	,	PUNCT
fnp-3910	145	16	irf8-/-/5xfad	irf8-/-/5xfad	ADP
fnp-3910	145	17	mice	mouse	NOUN
fnp-3910	145	18	(	(	PUNCT
fnp-3910	145	19	with	with	ADP
fnp-3910	145	20	less	less	ADV
fnp-3910	145	21	microglial	microglial	ADJ
fnp-3910	145	22	branching	branching	NOUN
fnp-3910	145	23	)	)	PUNCT
fnp-3910	145	24	,	,	PUNCT
fnp-3910	145	25	and	and	CCONJ
fnp-3910	145	26	microglia	microglia	ADV
fnp-3910	145	27	-	-	PUNCT
fnp-3910	145	28	depleted	deplete	VERB
fnp-3910	145	29	5xfad	5xfad	NUM
fnp-3910	145	30	mice	mouse	NOUN
fnp-3910	145	31	using	use	VERB
fnp-3910	145	32	csf-1r	csf-1r	NOUN
fnp-3910	145	33	inhibition	inhibition	NOUN
fnp-3910	145	34	exhibited	exhibit	VERB
fnp-3910	145	35	a	a	DET
fnp-3910	145	36	reduction	reduction	NOUN
fnp-3910	145	37	of	of	ADP
fnp-3910	145	38	aβ	aβ	DET
fnp-3910	145	39	plaques	plaque	NOUN
fnp-3910	145	40	in	in	ADP
fnp-3910	145	41	the	the	DET
fnp-3910	145	42	wt	wt	PROPN
fnp-3910	145	43	grafts	graft	NOUN
fnp-3910	145	44	,	,	PUNCT
fnp-3910	145	45	further	far	ADV
fnp-3910	145	46	corroborating	corroborate	VERB
fnp-3910	145	47	the	the	DET
fnp-3910	145	48	specific	specific	ADJ
fnp-3910	145	49	role	role	NOUN
fnp-3910	145	50	of	of	ADP
fnp-3910	145	51	microglia	microglia	NOUN
fnp-3910	145	52	in	in	ADP
fnp-3910	145	53	regulating	regulate	VERB
fnp-3910	145	54	aβ	aβ	DET
fnp-3910	145	55	propagation	propagation	NOUN
fnp-3910	145	56	.	.	PUNCT
fnp-3910	146	1	this	this	DET
fnp-3910	146	2	work	work	NOUN
fnp-3910	146	3	confirms	confirm	VERB
fnp-3910	146	4	that	that	SCONJ
fnp-3910	146	5	microglia	microglia	NOUN
fnp-3910	146	6	are	be	AUX
fnp-3910	146	7	involved	involve	VERB
fnp-3910	146	8	in	in	ADP
fnp-3910	146	9	the	the	DET
fnp-3910	146	10	pathogenic	pathogenic	ADJ
fnp-3910	146	11	spread	spread	NOUN
fnp-3910	146	12	of	of	ADP
fnp-3910	146	13	aβ	aβ	NOUN
fnp-3910	146	14	.	.	PUNCT
fnp-3910	147	1	they	they	PRON
fnp-3910	147	2	also	also	ADV
fnp-3910	147	3	went	go	VERB
fnp-3910	147	4	one	one	NUM
fnp-3910	147	5	step	step	NOUN
fnp-3910	147	6	further	far	ADV
fnp-3910	147	7	in	in	ADP
fnp-3910	147	8	a	a	DET
fnp-3910	147	9	final	final	ADJ
fnp-3910	147	10	experiment	experiment	NOUN
fnp-3910	147	11	.	.	PUNCT
fnp-3910	148	1	the	the	DET
fnp-3910	148	2	authors	author	NOUN
fnp-3910	148	3	used	use	VERB
fnp-3910	148	4	a	a	DET
fnp-3910	148	5	model	model	NOUN
fnp-3910	148	6	of	of	ADP
fnp-3910	148	7	laser	laser	NOUN
fnp-3910	148	8	-	-	PUNCT
fnp-3910	148	9	induced	induce	VERB
fnp-3910	148	10	focal	focal	ADJ
fnp-3910	148	11	tissue	tissue	NOUN
fnp-3910	148	12	injury	injury	NOUN
fnp-3910	148	13	and	and	CCONJ
fnp-3910	148	14	two	two	NUM
fnp-3910	148	15	-	-	PUNCT
fnp-3910	148	16	photon	photon	NOUN
fnp-3910	148	17	microscopy	microscopy	NOUN
fnp-3910	148	18	,	,	PUNCT
fnp-3910	148	19	and	and	CCONJ
fnp-3910	148	20	confirmed	confirm	VERB
fnp-3910	148	21	that	that	SCONJ
fnp-3910	148	22	aβ	aβ	PRON
fnp-3910	148	23	can	can	AUX
fnp-3910	148	24	be	be	AUX
fnp-3910	148	25	transported	transport	VERB
fnp-3910	148	26	by	by	ADP
fnp-3910	148	27	microglia	microglia	NOUN
fnp-3910	148	28	and	and	CCONJ
fnp-3910	148	29	form	form	VERB
fnp-3910	148	30	plaques	plaque	NOUN
fnp-3910	148	31	in	in	ADP
fnp-3910	148	32	the	the	DET
fnp-3910	148	33	lesioned	lesione	VERB
fnp-3910	148	34	tissue	tissue	NOUN
fnp-3910	148	35	(	(	PUNCT
fnp-3910	148	36	figure	figure	NOUN
fnp-3910	148	37	2	2	NUM
fnp-3910	148	38	)	)	PUNCT
fnp-3910	148	39	.	.	PUNCT
fnp-3910	149	1	in	in	ADP
fnp-3910	149	2	conclusion	conclusion	NOUN
fnp-3910	149	3	,	,	PUNCT
fnp-3910	149	4	this	this	DET
fnp-3910	149	5	study	study	NOUN
fnp-3910	149	6	suggests	suggest	VERB
fnp-3910	149	7	a	a	DET
fnp-3910	149	8	novel	novel	ADJ
fnp-3910	149	9	role	role	NOUN
fnp-3910	149	10	of	of	ADP
fnp-3910	149	11	microglia	microglia	NOUN
fnp-3910	149	12	in	in	ADP
fnp-3910	149	13	the	the	DET
fnp-3910	149	14	propagation	propagation	NOUN
fnp-3910	149	15	of	of	ADP
fnp-3910	149	16	aβ	aβ	DET
fnp-3910	149	17	pathology	pathology	NOUN
fnp-3910	149	18	in	in	ADP
fnp-3910	149	19	neurodegenerative	neurodegenerative	ADJ
fnp-3910	149	20	and	and	CCONJ
fnp-3910	149	21	neural	neural	ADJ
fnp-3910	149	22	injury	injury	NOUN
fnp-3910	149	23	models	model	NOUN
fnp-3910	149	24	.	.	PUNCT
fnp-3910	150	1	figure	figure	NOUN
fnp-3910	150	2	2	2	NUM
fnp-3910	150	3	.	.	PUNCT
fnp-3910	151	1	embryonic	embryonic	ADJ
fnp-3910	151	2	neuronal	neuronal	ADJ
fnp-3910	151	3	cells	cell	NOUN
fnp-3910	151	4	from	from	ADP
fnp-3910	151	5	wild	wild	ADJ
fnp-3910	151	6	-	-	PUNCT
fnp-3910	151	7	type	type	NOUN
fnp-3910	151	8	(	(	PUNCT
fnp-3910	151	9	wt	wt	NOUN
fnp-3910	151	10	)	)	PUNCT
fnp-3910	151	11	mice	mouse	NOUN
fnp-3910	151	12	were	be	AUX
fnp-3910	151	13	implanted	implant	VERB
fnp-3910	151	14	into	into	ADP
fnp-3910	151	15	the	the	DET
fnp-3910	151	16	neocortex	neocortex	NOUN
fnp-3910	151	17	of	of	ADP
fnp-3910	151	18	pre	pre	ADJ
fnp-3910	151	19	-	-	ADJ
fnp-3910	151	20	symptomatic	symptomatic	ADJ
fnp-3910	151	21	5xfad	5xfad	NUM
fnp-3910	151	22	transgenic	transgenic	NOUN
fnp-3910	151	23	mice	mouse	NOUN
fnp-3910	151	24	.	.	PUNCT
fnp-3910	152	1	aβ	aβ	DET
fnp-3910	152	2	plaques	plaque	NOUN
fnp-3910	152	3	developed	develop	VERB
fnp-3910	152	4	as	as	ADV
fnp-3910	152	5	early	early	ADV
fnp-3910	152	6	as	as	ADP
fnp-3910	152	7	4	4	NUM
fnp-3910	152	8	weeks	week	NOUN
fnp-3910	152	9	.	.	PUNCT
fnp-3910	153	1	aβ	aβ	PRON
fnp-3910	153	2	can	can	AUX
fnp-3910	153	3	be	be	AUX
fnp-3910	153	4	transported	transport	VERB
fnp-3910	153	5	by	by	ADP
fnp-3910	153	6	microglia	microglia	NOUN
fnp-3910	153	7	and	and	CCONJ
fnp-3910	153	8	form	form	VERB
fnp-3910	153	9	plaques	plaque	NOUN
fnp-3910	153	10	in	in	ADP
fnp-3910	153	11	the	the	DET
fnp-3910	153	12	lesioned	lesione	VERB
fnp-3910	153	13	tissue	tissue	NOUN
fnp-3910	153	14	.	.	PUNCT
fnp-3910	154	1	microglia	microglia	NOUN
fnp-3910	154	2	were	be	AUX
fnp-3910	154	3	involved	involve	VERB
fnp-3910	154	4	in	in	ADP
fnp-3910	154	5	the	the	DET
fnp-3910	154	6	propagation	propagation	NOUN
fnp-3910	154	7	of	of	ADP
fnp-3910	154	8	aβ	aβ	DET
fnp-3910	154	9	pathology	pathology	NOUN
fnp-3910	154	10	.	.	PUNCT
fnp-3910	155	1	created	create	VERB
fnp-3910	155	2	with	with	ADP
fnp-3910	155	3	biorender.com	biorender.com	X
fnp-3910	155	4	topic	topic	NOUN
fnp-3910	155	5	8	8	NUM
fnp-3910	155	6	:	:	PUNCT
fnp-3910	155	7	perivascular	perivascular	ADJ
fnp-3910	155	8	space	space	NOUN
fnp-3910	155	9	dilation	dilation	NOUN
fnp-3910	155	10	is	be	AUX
fnp-3910	155	11	associated	associate	VERB
fnp-3910	155	12	with	with	ADP
fnp-3910	155	13	vascular	vascular	ADJ
fnp-3910	155	14	amyloid	amyloid	NOUN
fnp-3910	155	15	-	-	PUNCT
fnp-3910	155	16	β	β	NOUN
fnp-3910	155	17	accumulation	accumulation	NOUN
fnp-3910	155	18	in	in	ADP
fnp-3910	155	19	the	the	DET
fnp-3910	155	20	overlying	overlying	ADJ
fnp-3910	155	21	cortex	cortex	NOUN
fnp-3910	155	22	this	this	DET
fnp-3910	155	23	work	work	NOUN
fnp-3910	155	24	examined	examine	VERB
fnp-3910	155	25	the	the	DET
fnp-3910	155	26	enlargement	enlargement	NOUN
fnp-3910	155	27	of	of	ADP
fnp-3910	155	28	the	the	DET
fnp-3910	155	29	perivascular	perivascular	ADJ
fnp-3910	155	30	space	space	NOUN
fnp-3910	155	31	(	(	PUNCT
fnp-3910	155	32	pvs	pvs	PROPN
fnp-3910	155	33	)	)	PUNCT
fnp-3910	155	34	in	in	ADP
fnp-3910	155	35	patients	patient	NOUN
fnp-3910	155	36	with	with	ADP
fnp-3910	155	37	cerebral	cerebral	ADJ
fnp-3910	155	38	amyloid	amyloid	NOUN
fnp-3910	155	39	angiopathy	angiopathy	ADJ
fnp-3910	155	40	(	(	PUNCT
fnp-3910	155	41	caa	caa	NOUN
fnp-3910	155	42	)	)	PUNCT
fnp-3910	155	43	,	,	PUNCT
fnp-3910	155	44	an	an	DET
fnp-3910	155	45	increasingly	increasingly	ADV
fnp-3910	155	46	common	common	ADJ
fnp-3910	155	47	form	form	NOUN
fnp-3910	155	48	of	of	ADP
fnp-3910	155	49	cerebral	cerebral	ADJ
fnp-3910	155	50	small	small	ADJ
fnp-3910	155	51	vessel	vessel	NOUN
fnp-3910	155	52	disease	disease	NOUN
fnp-3910	155	53	.	.	PUNCT
fnp-3910	156	1	caa	caa	PROPN
fnp-3910	156	2	is	be	AUX
fnp-3910	156	3	a	a	DET
fnp-3910	156	4	common	common	ADJ
fnp-3910	156	5	cause	cause	NOUN
fnp-3910	156	6	of	of	ADP
fnp-3910	156	7	lobar	lobar	ADJ
fnp-3910	156	8	hemorrhage	hemorrhage	NOUN
fnp-3910	156	9	,	,	PUNCT
fnp-3910	156	10	cortical	cortical	ADJ
fnp-3910	156	11	microhemorrhages	microhemorrhage	NOUN
fnp-3910	156	12	and	and	CCONJ
fnp-3910	156	13	white	white	ADJ
fnp-3910	156	14	matter	matter	NOUN
fnp-3910	156	15	disease	disease	NOUN
fnp-3910	156	16	in	in	ADP
fnp-3910	156	17	the	the	DET
fnp-3910	156	18	elderly	elderly	ADJ
fnp-3910	156	19	(	(	PUNCT
fnp-3910	156	20	figure	figure	NOUN
fnp-3910	156	21	3	3	NUM
fnp-3910	156	22	)	)	PUNCT
fnp-3910	156	23	.	.	PUNCT
fnp-3910	157	1	in	in	ADP
fnp-3910	157	2	caa	caa	NOUN
fnp-3910	157	3	,	,	PUNCT
fnp-3910	157	4	aβ	aβ	PRON
fnp-3910	157	5	accumulates	accumulate	VERB
fnp-3910	157	6	in	in	ADP
fnp-3910	157	7	the	the	DET
fnp-3910	157	8	walls	wall	NOUN
fnp-3910	157	9	of	of	ADP
fnp-3910	157	10	cortical	cortical	ADJ
fnp-3910	157	11	and	and	CCONJ
fnp-3910	157	12	leptomeningeal	leptomeningeal	ADJ
fnp-3910	157	13	arteries	artery	NOUN
fnp-3910	157	14	,	,	PUNCT
fnp-3910	157	15	resulting	result	VERB
fnp-3910	157	16	in	in	ADP
fnp-3910	157	17	a	a	DET
fnp-3910	157	18	loss	loss	NOUN
fnp-3910	157	19	of	of	ADP
fnp-3910	157	20	smooth	smooth	ADJ
fnp-3910	157	21	muscle	muscle	NOUN
fnp-3910	157	22	cells	cell	NOUN
fnp-3910	157	23	and	and	CCONJ
fnp-3910	157	24	impaired	impaired	ADJ
fnp-3910	157	25	vascular	vascular	ADJ
fnp-3910	157	26	function	function	NOUN
fnp-3910	157	27	and	and	CCONJ
fnp-3910	157	28	can	can	AUX
fnp-3910	157	29	lead	lead	VERB
fnp-3910	157	30	to	to	ADP
fnp-3910	157	31	lobar	lobar	ADJ
fnp-3910	157	32	intracerebral	intracerebral	ADJ
fnp-3910	157	33	hemorrhage	hemorrhage	NOUN
fnp-3910	157	34	in	in	ADP
fnp-3910	157	35	the	the	DET
fnp-3910	157	36	elderly	elderly	ADJ
fnp-3910	157	37	.	.	PUNCT
fnp-3910	158	1	the	the	DET
fnp-3910	158	2	presence	presence	NOUN
fnp-3910	158	3	of	of	ADP
fnp-3910	158	4	cerebral	cerebral	ADJ
fnp-3910	158	5	vascular	vascular	ADJ
fnp-3910	158	6	amyloid	amyloid	NOUN
fnp-3910	158	7	is	be	AUX
fnp-3910	158	8	a	a	DET
fnp-3910	158	9	common	common	ADJ
fnp-3910	158	10	neuropathological	neuropathological	ADJ
fnp-3910	158	11	feature	feature	NOUN
fnp-3910	158	12	in	in	ADP
fnp-3910	158	13	patients	patient	NOUN
fnp-3910	158	14	with	with	ADP
fnp-3910	158	15	ad	ad	NOUN
fnp-3910	158	16	.	.	PUNCT
fnp-3910	159	1	pvs	pvs	PROPN
fnp-3910	159	2	are	be	AUX
fnp-3910	159	3	compartments	compartment	NOUN
fnp-3910	159	4	surrounding	surround	VERB
fnp-3910	159	5	cerebral	cerebral	ADJ
fnp-3910	159	6	blood	blood	NOUN
fnp-3910	159	7	vessels	vessel	NOUN
fnp-3910	159	8	that	that	PRON
fnp-3910	159	9	become	become	VERB
fnp-3910	159	10	visible	visible	ADJ
fnp-3910	159	11	on	on	ADP
fnp-3910	159	12	mri	mri	NOUN
fnp-3910	159	13	when	when	SCONJ
fnp-3910	159	14	enlarged	enlarge	VERB
fnp-3910	159	15	.	.	PUNCT
fnp-3910	160	1	it	it	PRON
fnp-3910	160	2	has	have	AUX
fnp-3910	160	3	been	be	AUX
fnp-3910	160	4	suggested	suggest	VERB
fnp-3910	160	5	that	that	SCONJ
fnp-3910	160	6	these	these	DET
fnp-3910	160	7	spaces	space	NOUN
fnp-3910	160	8	enlarge	enlarge	VERB
fnp-3910	160	9	when	when	SCONJ
fnp-3910	160	10	there	there	PRON
fnp-3910	160	11	are	be	VERB
fnp-3910	160	12	deficits	deficit	NOUN
fnp-3910	160	13	in	in	ADP
fnp-3910	160	14	dysfunctional	dysfunctional	ADJ
fnp-3910	160	15	perivascular	perivascular	ADJ
fnp-3910	160	16	clearance	clearance	NOUN
fnp-3910	160	17	of	of	ADP
fnp-3910	160	18	waste	waste	NOUN
fnp-3910	160	19	products	product	NOUN
fnp-3910	160	20	from	from	ADP
fnp-3910	160	21	the	the	DET
fnp-3910	160	22	brain	brain	NOUN
fnp-3910	160	23	,	,	PUNCT
fnp-3910	160	24	including	include	VERB
fnp-3910	160	25	amyloid	amyloid	NOUN
fnp-3910	160	26	.	.	PUNCT
fnp-3910	161	1	the	the	DET
fnp-3910	161	2	presence	presence	NOUN
fnp-3910	161	3	of	of	ADP
fnp-3910	161	4	enlarged	enlarged	ADJ
fnp-3910	161	5	pvs	pvs	PROPN
fnp-3910	161	6	(	(	PUNCT
fnp-3910	161	7	epvs	epvs	PROPN
fnp-3910	161	8	)	)	PUNCT
fnp-3910	161	9	on	on	ADP
fnp-3910	161	10	mri	mri	NOUN
fnp-3910	161	11	is	be	AUX
fnp-3910	161	12	associated	associate	VERB
fnp-3910	161	13	with	with	ADP
fnp-3910	161	14	aging	age	VERB
fnp-3910	161	15	,	,	PUNCT
fnp-3910	161	16	high	high	ADJ
fnp-3910	161	17	blood	blood	NOUN
fnp-3910	161	18	pressure	pressure	NOUN
fnp-3910	161	19	,	,	PUNCT
fnp-3910	161	20	stroke	stroke	NOUN
fnp-3910	161	21	and	and	CCONJ
fnp-3910	161	22	cognitive	cognitive	ADJ
fnp-3910	161	23	decline	decline	NOUN
fnp-3910	161	24	in	in	ADP
fnp-3910	161	25	other	other	ADJ
fnp-3910	161	26	studies	study	NOUN
fnp-3910	161	27	.	.	PUNCT
fnp-3910	162	1	figure	figure	VERB
fnp-3910	162	2	3	3	NUM
fnp-3910	162	3	.	.	PUNCT
fnp-3910	162	4	mri	mri	NOUN
fnp-3910	162	5	and	and	CCONJ
fnp-3910	162	6	ct	ct	NOUN
fnp-3910	162	7	scan	scan	ADJ
fnp-3910	162	8	imaging	imaging	NOUN
fnp-3910	162	9	of	of	ADP
fnp-3910	162	10	a	a	DET
fnp-3910	162	11	73	73	NUM
fnp-3910	162	12	-	-	PUNCT
fnp-3910	162	13	year	year	NOUN
fnp-3910	162	14	-	-	PUNCT
fnp-3910	162	15	old	old	ADJ
fnp-3910	162	16	woman	woman	NOUN
fnp-3910	162	17	with	with	ADP
fnp-3910	162	18	pathogenically	pathogenically	ADV
fnp-3910	162	19	confirmed	confirm	VERB
fnp-3910	162	20	cerebral	cerebral	ADJ
fnp-3910	162	21	amyloid	amyloid	NOUN
fnp-3910	162	22	angiopathy	angiopathy	NOUN
fnp-3910	162	23	.	.	PUNCT
fnp-3910	163	1	panel	panel	NOUN
fnp-3910	163	2	a	a	DET
fnp-3910	163	3	shows	show	NOUN
fnp-3910	163	4	innumerable	innumerable	ADJ
fnp-3910	163	5	cortical	cortical	ADJ
fnp-3910	163	6	microhemorrhages	microhemorrhage	NOUN
fnp-3910	163	7	,	,	PUNCT
fnp-3910	163	8	panel	panel	NOUN
fnp-3910	163	9	b	b	NOUN
fnp-3910	163	10	demonstrates	demonstrate	VERB
fnp-3910	163	11	cortical	cortical	ADJ
fnp-3910	163	12	siderosis	siderosis	NOUN
fnp-3910	163	13	(	(	PUNCT
fnp-3910	163	14	gre	gre	PROPN
fnp-3910	163	15	)	)	PUNCT
fnp-3910	163	16	,	,	PUNCT
fnp-3910	163	17	and	and	CCONJ
fnp-3910	163	18	panel	panel	NOUN
fnp-3910	163	19	c	c	NOUN
fnp-3910	163	20	(	(	PUNCT
fnp-3910	163	21	flair	flair	NOUN
fnp-3910	163	22	)	)	PUNCT
fnp-3910	163	23	shows	show	VERB
fnp-3910	163	24	extensive	extensive	ADJ
fnp-3910	163	25	white	white	ADJ
fnp-3910	163	26	matter	matter	NOUN
fnp-3910	163	27	disease	disease	NOUN
fnp-3910	163	28	and	and	CCONJ
fnp-3910	163	29	cerebral	cerebral	ADJ
fnp-3910	163	30	atrophy	atrophy	NOUN
fnp-3910	163	31	.	.	PUNCT
fnp-3910	164	1	panel	panel	NOUN
fnp-3910	164	2	d	d	PROPN
fnp-3910	164	3	is	be	AUX
fnp-3910	164	4	a	a	DET
fnp-3910	164	5	ct	ct	NOUN
fnp-3910	164	6	scan	scan	NOUN
fnp-3910	164	7	taken	take	VERB
fnp-3910	164	8	3	3	NUM
fnp-3910	164	9	months	month	NOUN
fnp-3910	164	10	after	after	ADP
fnp-3910	164	11	her	her	PRON
fnp-3910	164	12	prior	prior	ADJ
fnp-3910	164	13	mri	mri	NOUN
fnp-3910	164	14	,	,	PUNCT
fnp-3910	164	15	when	when	SCONJ
fnp-3910	164	16	she	she	PRON
fnp-3910	164	17	presented	present	VERB
fnp-3910	164	18	with	with	ADP
fnp-3910	164	19	left	left	ADJ
fnp-3910	164	20	hemiparesis	hemiparesis	NOUN
fnp-3910	164	21	and	and	CCONJ
fnp-3910	164	22	mental	mental	ADJ
fnp-3910	164	23	status	status	NOUN
fnp-3910	164	24	changes	change	NOUN
fnp-3910	164	25	.	.	PUNCT
fnp-3910	165	1	a	a	DET
fnp-3910	165	2	large	large	ADJ
fnp-3910	165	3	lobal	lobal	ADJ
fnp-3910	165	4	hemorrhage	hemorrhage	NOUN
fnp-3910	165	5	is	be	AUX
fnp-3910	165	6	seen	see	VERB
fnp-3910	165	7	in	in	ADP
fnp-3910	165	8	the	the	DET
fnp-3910	165	9	right	right	ADJ
fnp-3910	165	10	frontal	frontal	ADJ
fnp-3910	165	11	area	area	NOUN
fnp-3910	165	12	,	,	PUNCT
fnp-3910	165	13	along	along	ADP
fnp-3910	165	14	with	with	ADP
fnp-3910	165	15	mass	mass	ADJ
fnp-3910	165	16	effect	effect	NOUN
fnp-3910	165	17	and	and	CCONJ
fnp-3910	165	18	cerebral	cerebral	ADJ
fnp-3910	165	19	edema	edema	NOUN
fnp-3910	165	20	.	.	PUNCT
fnp-3910	166	1	in	in	ADP
fnp-3910	166	2	this	this	DET
fnp-3910	166	3	paper	paper	NOUN
fnp-3910	166	4	(	(	PUNCT
fnp-3910	166	5	10	10	NUM
fnp-3910	166	6	)	)	PUNCT
fnp-3910	166	7	the	the	DET
fnp-3910	166	8	authors	author	NOUN
fnp-3910	166	9	used	use	VERB
fnp-3910	166	10	3	3	NUM
fnp-3910	166	11	t	t	NOUN
fnp-3910	166	12	and	and	CCONJ
fnp-3910	166	13	7	7	NUM
fnp-3910	166	14	t	t	NOUN
fnp-3910	166	15	ex	ex	PRON
fnp-3910	166	16	vivo	vivo	NOUN
fnp-3910	166	17	mri	mri	NOUN
fnp-3910	166	18	,	,	PUNCT
fnp-3910	166	19	semi	semi	ADJ
fnp-3910	166	20	-	-	ADJ
fnp-3910	166	21	automatic	automatic	ADJ
fnp-3910	166	22	segmentation	segmentation	NOUN
fnp-3910	166	23	and	and	CCONJ
fnp-3910	166	24	validated	validate	VERB
fnp-3910	166	25	deep	deep	ADJ
fnp-3910	166	26	-	-	PUNCT
fnp-3910	166	27	learning	learning	NOUN
fnp-3910	166	28	-	-	PUNCT
fnp-3910	166	29	based	base	VERB
fnp-3910	166	30	models	model	NOUN
fnp-3910	166	31	to	to	PART
fnp-3910	166	32	quantify	quantify	VERB
fnp-3910	166	33	epvs	epvs	NOUN
fnp-3910	166	34	and	and	CCONJ
fnp-3910	166	35	associated	associate	VERB
fnp-3910	166	36	histopathological	histopathological	ADJ
fnp-3910	166	37	abnormalities	abnormality	NOUN
fnp-3910	166	38	in	in	ADP
fnp-3910	166	39	19	19	NUM
fnp-3910	166	40	caa	caa	NOUN
fnp-3910	166	41	cases	case	NOUN
fnp-3910	166	42	and	and	CCONJ
fnp-3910	166	43	5	5	NUM
fnp-3910	166	44	controls	control	NOUN
fnp-3910	166	45	.	.	PUNCT
fnp-3910	167	1	severity	severity	NOUN
fnp-3910	167	2	of	of	ADP
fnp-3910	167	3	mri	mri	NOUN
fnp-3910	167	4	-	-	PUNCT
fnp-3910	167	5	visible	visible	ADJ
fnp-3910	167	6	pvs	pvs	NOUN
fnp-3910	167	7	during	during	ADP
fnp-3910	167	8	life	life	NOUN
fnp-3910	167	9	was	be	AUX
fnp-3910	167	10	significantly	significantly	ADV
fnp-3910	167	11	associated	associate	VERB
fnp-3910	167	12	with	with	ADP
fnp-3910	167	13	the	the	DET
fnp-3910	167	14	severity	severity	NOUN
fnp-3910	167	15	of	of	ADP
fnp-3910	167	16	mri	mri	NOUN
fnp-3910	167	17	-	-	PUNCT
fnp-3910	167	18	visible	visible	ADJ
fnp-3910	167	19	pvs	pvs	NOUN
fnp-3910	167	20	on	on	ADP
fnp-3910	167	21	ex	ex	PRON
fnp-3910	167	22	vivo	vivo	NOUN
fnp-3910	167	23	mri	mri	NOUN
fnp-3910	167	24	.	.	PUNCT
fnp-3910	168	1	this	this	PRON
fnp-3910	168	2	also	also	ADV
fnp-3910	168	3	corresponded	correspond	VERB
fnp-3910	168	4	with	with	ADP
fnp-3910	168	5	pvs	pvs	PROPN
fnp-3910	168	6	enlargement	enlargement	NOUN
fnp-3910	168	7	on	on	ADP
fnp-3910	168	8	histopathology	histopathology	NOUN
fnp-3910	168	9	in	in	ADP
fnp-3910	168	10	the	the	DET
fnp-3910	168	11	same	same	ADJ
fnp-3910	168	12	areas	area	NOUN
fnp-3910	168	13	.	.	PUNCT
fnp-3910	169	1	epvs	epvs	PROPN
fnp-3910	169	2	were	be	AUX
fnp-3910	169	3	located	locate	VERB
fnp-3910	169	4	mainly	mainly	ADV
fnp-3910	169	5	around	around	ADP
fnp-3910	169	6	the	the	DET
fnp-3910	169	7	white	white	ADJ
fnp-3910	169	8	matter	matter	NOUN
fnp-3910	169	9	of	of	ADP
fnp-3910	169	10	perforating	perforate	VERB
fnp-3910	169	11	cortical	cortical	ADJ
fnp-3910	169	12	arterioles	arteriole	NOUN
fnp-3910	169	13	.	.	PUNCT
fnp-3910	170	1	the	the	DET
fnp-3910	170	2	amount	amount	NOUN
fnp-3910	170	3	of	of	ADP
fnp-3910	170	4	epvs	epvs	NOUN
fnp-3910	170	5	was	be	AUX
fnp-3910	170	6	associated	associate	VERB
fnp-3910	170	7	with	with	ADP
fnp-3910	170	8	caa	caa	NOUN
fnp-3910	170	9	severity	severity	NOUN
fnp-3910	170	10	in	in	ADP
fnp-3910	170	11	the	the	DET
fnp-3910	170	12	overlying	overlying	ADJ
fnp-3910	170	13	cortex	cortex	NOUN
fnp-3910	170	14	.	.	PUNCT
fnp-3910	171	1	in	in	ADP
fnp-3910	171	2	addition	addition	NOUN
fnp-3910	171	3	,	,	PUNCT
fnp-3910	171	4	the	the	DET
fnp-3910	171	5	authors	author	NOUN
fnp-3910	171	6	found	find	VERB
fnp-3910	171	7	markedly	markedly	ADV
fnp-3910	171	8	reduced	reduce	VERB
fnp-3910	171	9	smooth	smooth	ADJ
fnp-3910	171	10	muscle	muscle	NOUN
fnp-3910	171	11	cells	cell	NOUN
fnp-3910	171	12	and	and	CCONJ
fnp-3910	171	13	increased	increase	VERB
fnp-3910	171	14	vascular	vascular	NOUN
fnp-3910	171	15	aβ	aβ	NOUN
fnp-3910	171	16	accumulation	accumulation	NOUN
fnp-3910	171	17	,	,	PUNCT
fnp-3910	171	18	extending	extend	VERB
fnp-3910	171	19	into	into	ADP
fnp-3910	171	20	the	the	DET
fnp-3910	171	21	wm	wm	PROPN
fnp-3910	171	22	,	,	PUNCT
fnp-3910	171	23	was	be	AUX
fnp-3910	171	24	seen	see	VERB
fnp-3910	171	25	in	in	ADP
fnp-3910	171	26	individual	individual	ADJ
fnp-3910	171	27	affected	affect	VERB
fnp-3910	171	28	vessels	vessel	NOUN
fnp-3910	171	29	with	with	ADP
fnp-3910	171	30	an	an	DET
fnp-3910	171	31	epvs	epvs	NOUN
fnp-3910	171	32	.	.	PUNCT
fnp-3910	172	1	the	the	DET
fnp-3910	172	2	presence	presence	NOUN
fnp-3910	172	3	of	of	ADP
fnp-3910	172	4	aβ	aβ	PRON
fnp-3910	172	5	was	be	AUX
fnp-3910	172	6	also	also	ADV
fnp-3910	172	7	observed	observe	VERB
fnp-3910	172	8	in	in	ADP
fnp-3910	172	9	the	the	DET
fnp-3910	172	10	wm	wm	PROPN
fnp-3910	172	11	portion	portion	NOUN
fnp-3910	172	12	of	of	ADP
fnp-3910	172	13	the	the	DET
fnp-3910	172	14	same	same	ADJ
fnp-3910	172	15	perforating	perforating	NOUN
fnp-3910	172	16	vessels	vessel	NOUN
fnp-3910	172	17	,	,	PUNCT
fnp-3910	172	18	decreasing	decrease	VERB
fnp-3910	172	19	in	in	ADP
fnp-3910	172	20	intensity	intensity	NOUN
fnp-3910	172	21	with	with	ADP
fnp-3910	172	22	increasing	increase	VERB
fnp-3910	172	23	distance	distance	NOUN
fnp-3910	172	24	from	from	ADP
fnp-3910	172	25	the	the	DET
fnp-3910	172	26	cortex	cortex	NOUN
fnp-3910	172	27	.	.	PUNCT
fnp-3910	173	1	this	this	PRON
fnp-3910	173	2	could	could	AUX
fnp-3910	173	3	reflect	reflect	VERB
fnp-3910	173	4	blockage	blockage	NOUN
fnp-3910	173	5	of	of	ADP
fnp-3910	173	6	aβ	aβ	PRON
fnp-3910	173	7	clearance	clearance	NOUN
fnp-3910	173	8	towards	towards	ADP
fnp-3910	173	9	the	the	DET
fnp-3910	173	10	brain	brain	NOUN
fnp-3910	173	11	surface	surface	NOUN
fnp-3910	173	12	,	,	PUNCT
fnp-3910	173	13	consistent	consistent	ADJ
fnp-3910	173	14	with	with	ADP
fnp-3910	173	15	the	the	DET
fnp-3910	173	16	decreasing	decrease	VERB
fnp-3910	173	17	severity	severity	NOUN
fnp-3910	173	18	of	of	ADP
fnp-3910	173	19	caa	caa	NOUN
fnp-3910	173	20	between	between	ADP
fnp-3910	173	21	superficial	superficial	ADJ
fnp-3910	173	22	and	and	CCONJ
fnp-3910	173	23	deep	deep	ADJ
fnp-3910	173	24	cortical	cortical	ADJ
fnp-3910	173	25	layers	layer	NOUN
fnp-3910	173	26	,	,	PUNCT
fnp-3910	173	27	as	as	SCONJ
fnp-3910	173	28	previously	previously	ADV
fnp-3910	173	29	shown	show	VERB
fnp-3910	173	30	histologically	histologically	ADV
fnp-3910	173	31	.	.	PUNCT
fnp-3910	174	1	these	these	DET
fnp-3910	174	2	findings	finding	NOUN
fnp-3910	174	3	were	be	AUX
fnp-3910	174	4	confirmed	confirm	VERB
fnp-3910	174	5	in	in	ADP
fnp-3910	174	6	a	a	DET
fnp-3910	174	7	patient	patient	NOUN
fnp-3910	174	8	with	with	ADP
fnp-3910	174	9	hereditary	hereditary	ADJ
fnp-3910	174	10	amyloid	amyloid	NOUN
fnp-3910	174	11	that	that	PRON
fnp-3910	174	12	was	be	AUX
fnp-3910	174	13	much	much	ADV
fnp-3910	174	14	younger	young	ADJ
fnp-3910	174	15	(	(	PUNCT
fnp-3910	174	16	dutch	dutch	ADJ
fnp-3910	174	17	mutation	mutation	NOUN
fnp-3910	174	18	)	)	PUNCT
fnp-3910	174	19	.	.	PUNCT
fnp-3910	175	1	these	these	DET
fnp-3910	175	2	findings	finding	NOUN
fnp-3910	175	3	are	be	AUX
fnp-3910	175	4	consistent	consistent	ADJ
fnp-3910	175	5	with	with	ADP
fnp-3910	175	6	the	the	DET
fnp-3910	175	7	concept	concept	NOUN
fnp-3910	175	8	that	that	SCONJ
fnp-3910	175	9	the	the	DET
fnp-3910	175	10	development	development	NOUN
fnp-3910	175	11	of	of	ADP
fnp-3910	175	12	epvs	epvs	PROPN
fnp-3910	175	13	reflects	reflect	VERB
fnp-3910	175	14	impaired	impair	VERB
fnp-3910	175	15	outward	outward	ADJ
fnp-3910	175	16	flow	flow	NOUN
fnp-3910	175	17	along	along	ADP
fnp-3910	175	18	arterioles	arterioles	PROPN
fnp-3910	175	19	.	.	PUNCT
fnp-3910	176	1	this	this	PRON
fnp-3910	176	2	has	have	VERB
fnp-3910	176	3	implications	implication	NOUN
fnp-3910	176	4	for	for	ADP
fnp-3910	176	5	other	other	ADJ
fnp-3910	176	6	small	small	ADJ
fnp-3910	176	7	vessel	vessel	NOUN
fnp-3910	176	8	diseases	disease	NOUN
fnp-3910	176	9	and	and	CCONJ
fnp-3910	176	10	suggests	suggest	VERB
fnp-3910	176	11	the	the	DET
fnp-3910	176	12	importance	importance	NOUN
fnp-3910	176	13	of	of	ADP
fnp-3910	176	14	perivascular	perivascular	ADJ
fnp-3910	176	15	clearance	clearance	NOUN
fnp-3910	176	16	mechanisms	mechanism	NOUN
fnp-3910	176	17	in	in	ADP
fnp-3910	176	18	human	human	ADJ
fnp-3910	176	19	brain	brain	NOUN
fnp-3910	176	20	,	,	PUNCT
fnp-3910	176	21	which	which	PRON
fnp-3910	176	22	play	play	VERB
fnp-3910	176	23	an	an	DET
fnp-3910	176	24	important	important	ADJ
fnp-3910	176	25	role	role	NOUN
fnp-3910	176	26	in	in	ADP
fnp-3910	176	27	the	the	DET
fnp-3910	176	28	pathophysiology	pathophysiology	NOUN
fnp-3910	176	29	of	of	ADP
fnp-3910	176	30	both	both	DET
fnp-3910	176	31	caa	caa	NOUN
fnp-3910	176	32	and	and	CCONJ
fnp-3910	176	33	ad	ad	NOUN
fnp-3910	176	34	.	.	PUNCT
fnp-3910	177	1	these	these	DET
fnp-3910	177	2	results	result	NOUN
fnp-3910	177	3	support	support	VERB
fnp-3910	177	4	the	the	DET
fnp-3910	177	5	concept	concept	NOUN
fnp-3910	177	6	of	of	ADP
fnp-3910	177	7	outward	outward	ADJ
fnp-3910	177	8	flow	flow	NOUN
fnp-3910	177	9	along	along	ADP
fnp-3910	177	10	the	the	DET
fnp-3910	177	11	walls	wall	NOUN
fnp-3910	177	12	of	of	ADP
fnp-3910	177	13	cortical	cortical	ADJ
fnp-3910	177	14	arterioles	arteriole	NOUN
fnp-3910	177	15	and	and	CCONJ
fnp-3910	177	16	suggest	suggest	VERB
fnp-3910	177	17	that	that	SCONJ
fnp-3910	177	18	impaired	impaired	ADJ
fnp-3910	177	19	perivascular	perivascular	ADJ
fnp-3910	177	20	clearance	clearance	NOUN
fnp-3910	177	21	of	of	ADP
fnp-3910	177	22	aβ	aβ	PRON
fnp-3910	177	23	might	might	AUX
fnp-3910	177	24	lead	lead	VERB
fnp-3910	177	25	to	to	ADP
fnp-3910	177	26	fluid	fluid	ADJ
fnp-3910	177	27	stagnation	stagnation	NOUN
fnp-3910	177	28	and	and	CCONJ
fnp-3910	177	29	pvs	pvs	PROPN
fnp-3910	177	30	enlargement	enlargement	NOUN
fnp-3910	177	31	around	around	ADP
fnp-3910	177	32	upstream	upstream	ADJ
fnp-3910	177	33	portions	portion	NOUN
fnp-3910	177	34	of	of	ADP
fnp-3910	177	35	connected	connected	ADJ
fnp-3910	177	36	perivascular	perivascular	ADJ
fnp-3910	177	37	compartments	compartment	NOUN
fnp-3910	177	38	.	.	PUNCT
fnp-3910	178	1	interestingly	interestingly	ADV
fnp-3910	178	2	,	,	PUNCT
fnp-3910	178	3	removal	removal	NOUN
fnp-3910	178	4	of	of	ADP
fnp-3910	178	5	aβ	aβ	PRON
fnp-3910	178	6	plaques	plaque	NOUN
fnp-3910	178	7	with	with	ADP
fnp-3910	178	8	anti	anti	ADJ
fnp-3910	178	9	-	-	ADJ
fnp-3910	178	10	aβ	aβ	ADJ
fnp-3910	178	11	immunotherapy	immunotherapy	NOUN
fnp-3910	178	12	can	can	AUX
fnp-3910	178	13	worsen	worsen	VERB
fnp-3910	178	14	cortical	cortical	ADJ
fnp-3910	178	15	and	and	CCONJ
fnp-3910	178	16	leptomeningeal	leptomeningeal	ADJ
fnp-3910	178	17	caa	caa	NOUN
fnp-3910	178	18	(	(	PUNCT
fnp-3910	178	19	11	11	NUM
fnp-3910	178	20	)	)	PUNCT
fnp-3910	178	21	,	,	PUNCT
fnp-3910	178	22	suggesting	suggest	VERB
fnp-3910	178	23	that	that	SCONJ
fnp-3910	178	24	after	after	ADP
fnp-3910	178	25	plaque	plaque	NOUN
fnp-3910	178	26	disaggregation	disaggregation	NOUN
fnp-3910	178	27	aβ	aβ	NOUN
fnp-3910	178	28	is	be	AUX
fnp-3910	178	29	cleared	clear	VERB
fnp-3910	178	30	along	along	ADP
fnp-3910	178	31	the	the	DET
fnp-3910	178	32	cerebral	cerebral	ADJ
fnp-3910	178	33	vessels	vessel	NOUN
fnp-3910	178	34	.	.	PUNCT
fnp-3910	179	1	considering	consider	VERB
fnp-3910	179	2	the	the	DET
fnp-3910	179	3	currently	currently	ADV
fnp-3910	179	4	unknown	unknown	ADJ
fnp-3910	179	5	role	role	NOUN
fnp-3910	179	6	of	of	ADP
fnp-3910	179	7	epvs	epvs	NOUN
fnp-3910	179	8	and	and	CCONJ
fnp-3910	179	9	white	white	ADJ
fnp-3910	179	10	matter	matter	NOUN
fnp-3910	179	11	hyper	hyper	NOUN
fnp-3910	179	12	-	-	NOUN
fnp-3910	179	13	intensities	intensity	NOUN
fnp-3910	179	14	(	(	PUNCT
fnp-3910	179	15	wmhs	wmhs	NOUN
fnp-3910	179	16	)	)	PUNCT
fnp-3910	179	17	and	and	CCONJ
fnp-3910	179	18	what	what	PRON
fnp-3910	179	19	they	they	PRON
fnp-3910	179	20	signify	signify	VERB
fnp-3910	179	21	in	in	ADP
fnp-3910	179	22	humans	human	NOUN
fnp-3910	179	23	both	both	CCONJ
fnp-3910	179	24	with	with	ADP
fnp-3910	179	25	and	and	CCONJ
fnp-3910	179	26	without	without	ADP
fnp-3910	179	27	ad	ad	NOUN
fnp-3910	179	28	/	/	SYM
fnp-3910	179	29	caa	caa	NOUN
fnp-3910	179	30	,	,	PUNCT
fnp-3910	179	31	this	this	DET
fnp-3910	179	32	paper	paper	NOUN
fnp-3910	179	33	has	have	VERB
fnp-3910	179	34	important	important	ADJ
fnp-3910	179	35	clinical	clinical	ADJ
fnp-3910	179	36	and	and	CCONJ
fnp-3910	179	37	pathophysiological	pathophysiological	ADJ
fnp-3910	179	38	relevance	relevance	NOUN
fnp-3910	179	39	.	.	PUNCT
fnp-3910	180	1	topic	topic	NOUN
fnp-3910	180	2	9	9	NUM
fnp-3910	180	3	:	:	PUNCT
fnp-3910	180	4	telomerase	telomerase	NOUN
fnp-3910	180	5	therapy	therapy	NOUN
fnp-3910	180	6	reverses	reverse	VERB
fnp-3910	180	7	vascular	vascular	ADJ
fnp-3910	180	8	senescence	senescence	NOUN
fnp-3910	180	9	and	and	CCONJ
fnp-3910	180	10	extends	extend	VERB
fnp-3910	180	11	lifespan	lifespan	NOUN
fnp-3910	180	12	in	in	ADP
fnp-3910	180	13	progeria	progeria	NOUN
fnp-3910	180	14	mice	mouse	NOUN
fnp-3910	180	15	aging	age	VERB
fnp-3910	180	16	is	be	AUX
fnp-3910	180	17	a	a	DET
fnp-3910	180	18	major	major	ADJ
fnp-3910	180	19	risk	risk	NOUN
fnp-3910	180	20	factor	factor	NOUN
fnp-3910	180	21	for	for	ADP
fnp-3910	180	22	cardiovascular	cardiovascular	ADJ
fnp-3910	180	23	disease	disease	NOUN
fnp-3910	180	24	.	.	PUNCT
fnp-3910	181	1	with	with	ADP
fnp-3910	181	2	aging	aging	NOUN
fnp-3910	181	3	,	,	PUNCT
fnp-3910	181	4	the	the	DET
fnp-3910	181	5	vasculature	vasculature	NOUN
fnp-3910	181	6	is	be	AUX
fnp-3910	181	7	altered	alter	VERB
fnp-3910	181	8	,	,	PUNCT
fnp-3910	181	9	and	and	CCONJ
fnp-3910	181	10	molecular	molecular	ADJ
fnp-3910	181	11	and	and	CCONJ
fnp-3910	181	12	structural	structural	ADJ
fnp-3910	181	13	changes	change	NOUN
fnp-3910	181	14	occur	occur	VERB
fnp-3910	181	15	in	in	ADP
fnp-3910	181	16	endothelial	endothelial	ADJ
fnp-3910	181	17	cells	cell	NOUN
fnp-3910	181	18	.	.	PUNCT
fnp-3910	182	1	senescent	senescent	ADJ
fnp-3910	182	2	endothelial	endothelial	ADJ
fnp-3910	182	3	cells	cell	NOUN
fnp-3910	182	4	show	show	VERB
fnp-3910	182	5	enhanced	enhance	VERB
fnp-3910	182	6	oxidative	oxidative	ADJ
fnp-3910	182	7	stress	stress	NOUN
fnp-3910	182	8	and	and	CCONJ
fnp-3910	182	9	dna	dna	NOUN
fnp-3910	182	10	damages	damage	NOUN
fnp-3910	182	11	,	,	PUNCT
fnp-3910	182	12	aberrant	aberrant	ADJ
fnp-3910	182	13	chromatin	chromatin	NOUN
fnp-3910	182	14	changes	change	NOUN
fnp-3910	182	15	,	,	PUNCT
fnp-3910	182	16	alteration	alteration	NOUN
fnp-3910	182	17	in	in	ADP
fnp-3910	182	18	the	the	DET
fnp-3910	182	19	nuclear	nuclear	ADJ
fnp-3910	182	20	envelope	envelope	NOUN
fnp-3910	182	21	,	,	PUNCT
fnp-3910	182	22	telomere	telomere	NOUN
fnp-3910	182	23	erosion	erosion	NOUN
fnp-3910	182	24	,	,	PUNCT
fnp-3910	182	25	and	and	CCONJ
fnp-3910	182	26	increased	increase	VERB
fnp-3910	182	27	production	production	NOUN
fnp-3910	182	28	and	and	CCONJ
fnp-3910	182	29	secretion	secretion	NOUN
fnp-3910	182	30	of	of	ADP
fnp-3910	182	31	pro	pro	ADJ
fnp-3910	182	32	-	-	ADJ
fnp-3910	182	33	inflammatory	inflammatory	ADJ
fnp-3910	182	34	molecules	molecule	NOUN
fnp-3910	182	35	that	that	PRON
fnp-3910	182	36	negatively	negatively	ADV
fnp-3910	182	37	affect	affect	VERB
fnp-3910	182	38	neighboring	neighboring	NOUN
fnp-3910	182	39	cells	cell	NOUN
fnp-3910	182	40	.	.	PUNCT
fnp-3910	183	1	given	give	VERB
fnp-3910	183	2	that	that	PRON
fnp-3910	183	3	endothelial	endothelial	ADJ
fnp-3910	183	4	function	function	NOUN
fnp-3910	183	5	regulates	regulate	VERB
fnp-3910	183	6	organ	organ	NOUN
fnp-3910	183	7	perfusion	perfusion	NOUN
fnp-3910	183	8	,	,	PUNCT
fnp-3910	183	9	inflammation	inflammation	NOUN
fnp-3910	183	10	and	and	CCONJ
fnp-3910	183	11	accommodates	accommodate	VERB
fnp-3910	183	12	resident	resident	NOUN
fnp-3910	183	13	stem	stem	NOUN
fnp-3910	183	14	cells	cell	NOUN
fnp-3910	183	15	responsible	responsible	ADJ
fnp-3910	183	16	for	for	ADP
fnp-3910	183	17	tissue	tissue	NOUN
fnp-3910	183	18	repair	repair	NOUN
fnp-3910	183	19	,	,	PUNCT
fnp-3910	183	20	it	it	PRON
fnp-3910	183	21	is	be	AUX
fnp-3910	183	22	expected	expect	VERB
fnp-3910	183	23	that	that	SCONJ
fnp-3910	183	24	restoring	restore	VERB
fnp-3910	183	25	vascular	vascular	ADJ
fnp-3910	183	26	homeostasis	homeostasis	NOUN
fnp-3910	183	27	in	in	ADP
fnp-3910	183	28	aged	aged	ADJ
fnp-3910	183	29	organisms	organism	NOUN
fnp-3910	183	30	would	would	AUX
fnp-3910	183	31	improve	improve	VERB
fnp-3910	183	32	organ	organ	NOUN
fnp-3910	183	33	function	function	NOUN
fnp-3910	183	34	and	and	CCONJ
fnp-3910	183	35	extend	extend	VERB
fnp-3910	183	36	lifespan	lifespan	NOUN
fnp-3910	183	37	.	.	PUNCT
fnp-3910	184	1	hutchinson	hutchinson	PROPN
fnp-3910	184	2	-	-	PUNCT
fnp-3910	184	3	gilford	gilford	PROPN
fnp-3910	184	4	progeria	progeria	NOUN
fnp-3910	184	5	syndrome	syndrome	NOUN
fnp-3910	184	6	(	(	PUNCT
fnp-3910	184	7	hgps	hgps	PROPN
fnp-3910	184	8	)	)	PUNCT
fnp-3910	184	9	is	be	AUX
fnp-3910	184	10	a	a	DET
fnp-3910	184	11	pediatric	pediatric	ADJ
fnp-3910	184	12	genetic	genetic	ADJ
fnp-3910	184	13	disease	disease	NOUN
fnp-3910	184	14	characterized	characterize	VERB
fnp-3910	184	15	by	by	ADP
fnp-3910	184	16	accelerated	accelerated	ADJ
fnp-3910	184	17	aging	aging	NOUN
fnp-3910	184	18	.	.	PUNCT
fnp-3910	185	1	90	90	NUM
fnp-3910	185	2	%	%	NOUN
fnp-3910	185	3	of	of	ADP
fnp-3910	185	4	hgps	hgps	NOUN
fnp-3910	185	5	patients	patient	NOUN
fnp-3910	185	6	manifest	manifest	VERB
fnp-3910	185	7	cardiovascular	cardiovascular	ADJ
fnp-3910	185	8	disease	disease	NOUN
fnp-3910	185	9	early	early	ADV
fnp-3910	185	10	in	in	ADP
fnp-3910	185	11	life	life	NOUN
fnp-3910	185	12	,	,	PUNCT
fnp-3910	185	13	in	in	ADP
fnp-3910	185	14	their	their	PRON
fnp-3910	185	15	teenage	teenage	ADJ
fnp-3910	185	16	years	year	NOUN
fnp-3910	185	17	.	.	PUNCT
fnp-3910	186	1	hgps	hgp	NOUN
fnp-3910	186	2	is	be	AUX
fnp-3910	186	3	caused	cause	VERB
fnp-3910	186	4	by	by	ADP
fnp-3910	186	5	a	a	DET
fnp-3910	186	6	mutation	mutation	NOUN
fnp-3910	186	7	in	in	ADP
fnp-3910	186	8	a	a	DET
fnp-3910	186	9	nuclear	nuclear	ADJ
fnp-3910	186	10	envelop	envelop	NOUN
fnp-3910	186	11	protein	protein	NOUN
fnp-3910	186	12	(	(	PUNCT
fnp-3910	186	13	lamin	lamin	VERB
fnp-3910	186	14	a	a	PRON
fnp-3910	186	15	or	or	CCONJ
fnp-3910	186	16	progerin	progerin	NOUN
fnp-3910	186	17	)	)	PUNCT
fnp-3910	186	18	,	,	PUNCT
fnp-3910	186	19	which	which	PRON
fnp-3910	186	20	leads	lead	VERB
fnp-3910	186	21	to	to	ADP
fnp-3910	186	22	deleterious	deleterious	ADJ
fnp-3910	186	23	consequences	consequence	NOUN
fnp-3910	186	24	in	in	ADP
fnp-3910	186	25	nuclear	nuclear	ADJ
fnp-3910	186	26	morphology	morphology	NOUN
fnp-3910	186	27	and	and	CCONJ
fnp-3910	186	28	gene	gene	NOUN
fnp-3910	186	29	expression	expression	NOUN
fnp-3910	186	30	.	.	PUNCT
fnp-3910	187	1	unfortunately	unfortunately	ADV
fnp-3910	187	2	,	,	PUNCT
fnp-3910	187	3	treatments	treatment	NOUN
fnp-3910	187	4	to	to	PART
fnp-3910	187	5	mitigate	mitigate	VERB
fnp-3910	187	6	this	this	DET
fnp-3910	187	7	cardiovascular	cardiovascular	ADJ
fnp-3910	187	8	pathology	pathology	NOUN
fnp-3910	187	9	are	be	AUX
fnp-3910	187	10	limited	limited	ADJ
fnp-3910	187	11	.	.	PUNCT
fnp-3910	188	1	the	the	DET
fnp-3910	188	2	authors	author	NOUN
fnp-3910	188	3	(	(	PUNCT
fnp-3910	188	4	11	11	NUM
fnp-3910	188	5	)	)	PUNCT
fnp-3910	188	6	used	use	VERB
fnp-3910	188	7	induced	induce	VERB
fnp-3910	188	8	pluripotent	pluripotent	ADJ
fnp-3910	188	9	stem	stem	NOUN
fnp-3910	188	10	cells	cell	NOUN
fnp-3910	188	11	(	(	PUNCT
fnp-3910	188	12	ipscs	ipscs	NOUN
fnp-3910	188	13	)	)	PUNCT
fnp-3910	188	14	derived	derive	VERB
fnp-3910	188	15	from	from	ADP
fnp-3910	188	16	hgps	hgps	NOUN
fnp-3910	188	17	patients	patient	NOUN
fnp-3910	188	18	,	,	PUNCT
fnp-3910	188	19	in	in	ADP
fnp-3910	188	20	addition	addition	NOUN
fnp-3910	188	21	to	to	ADP
fnp-3910	188	22	a	a	DET
fnp-3910	188	23	hgps	hgps	NOUN
fnp-3910	188	24	mouse	mouse	NOUN
fnp-3910	188	25	model	model	NOUN
fnp-3910	188	26	to	to	PART
fnp-3910	188	27	determine	determine	VERB
fnp-3910	188	28	if	if	SCONJ
fnp-3910	188	29	reversing	reverse	VERB
fnp-3910	188	30	the	the	DET
fnp-3910	188	31	senescence	senescence	NOUN
fnp-3910	188	32	-	-	PUNCT
fnp-3910	188	33	associated	associate	VERB
fnp-3910	188	34	phenotype	phenotype	NOUN
fnp-3910	188	35	in	in	ADP
fnp-3910	188	36	the	the	DET
fnp-3910	188	37	vasculature	vasculature	NOUN
fnp-3910	188	38	had	have	VERB
fnp-3910	188	39	beneficial	beneficial	ADJ
fnp-3910	188	40	effects	effect	NOUN
fnp-3910	188	41	on	on	ADP
fnp-3910	188	42	lifespan	lifespan	NOUN
fnp-3910	188	43	and	and	CCONJ
fnp-3910	188	44	behavior	behavior	NOUN
fnp-3910	188	45	in	in	ADP
fnp-3910	188	46	mice	mouse	NOUN
fnp-3910	188	47	.	.	PUNCT
fnp-3910	189	1	they	they	PRON
fnp-3910	189	2	found	find	VERB
fnp-3910	189	3	that	that	SCONJ
fnp-3910	189	4	transient	transient	ADJ
fnp-3910	189	5	delivery	delivery	NOUN
fnp-3910	189	6	of	of	ADP
fnp-3910	189	7	modified	modify	VERB
fnp-3910	189	8	mrna	mrna	PROPN
fnp-3910	189	9	encoding	encoding	NOUN
fnp-3910	189	10	for	for	ADP
fnp-3910	189	11	an	an	DET
fnp-3910	189	12	enzyme	enzyme	NOUN
fnp-3910	189	13	that	that	PRON
fnp-3910	189	14	prevents	prevent	VERB
fnp-3910	189	15	telomere	telomere	NOUN
fnp-3910	189	16	shortening	shortening	NOUN
fnp-3910	189	17	(	(	PUNCT
fnp-3910	189	18	human	human	ADJ
fnp-3910	189	19	telomerase	telomerase	NOUN
fnp-3910	189	20	,	,	PUNCT
fnp-3910	189	21	htert	htert	NOUN
fnp-3910	189	22	)	)	PUNCT
fnp-3910	189	23	,	,	PUNCT
fnp-3910	189	24	which	which	PRON
fnp-3910	189	25	is	be	AUX
fnp-3910	189	26	a	a	DET
fnp-3910	189	27	distinct	distinct	ADJ
fnp-3910	189	28	feature	feature	NOUN
fnp-3910	189	29	of	of	ADP
fnp-3910	189	30	cell	cell	NOUN
fnp-3910	189	31	senescence	senescence	NOUN
fnp-3910	189	32	,	,	PUNCT
fnp-3910	189	33	restored	restore	VERB
fnp-3910	189	34	endothelial	endothelial	ADJ
fnp-3910	189	35	proliferation	proliferation	NOUN
fnp-3910	189	36	and	and	CCONJ
fnp-3910	189	37	function	function	NOUN
fnp-3910	189	38	,	,	PUNCT
fnp-3910	189	39	upregulated	upregulate	VERB
fnp-3910	189	40	lamin	lamin	NOUN
fnp-3910	189	41	a	a	PRON
fnp-3910	189	42	,	,	PUNCT
fnp-3910	189	43	mitigated	mitigate	VERB
fnp-3910	189	44	dna	dna	NOUN
fnp-3910	189	45	damage	damage	NOUN
fnp-3910	189	46	,	,	PUNCT
fnp-3910	189	47	and	and	CCONJ
fnp-3910	189	48	reversed	reverse	VERB
fnp-3910	189	49	the	the	DET
fnp-3910	189	50	inflammatory	inflammatory	ADJ
fnp-3910	189	51	secretome	secretome	NOUN
fnp-3910	189	52	seen	see	VERB
fnp-3910	189	53	in	in	ADP
fnp-3910	189	54	cultured	cultured	ADJ
fnp-3910	189	55	hgps	hgps	NOUN
fnp-3910	189	56	endothelial	endothelial	NOUN
fnp-3910	189	57	cells	cell	NOUN
fnp-3910	189	58	(	(	PUNCT
fnp-3910	189	59	figure	figure	NOUN
fnp-3910	189	60	4	4	NUM
fnp-3910	189	61	)	)	PUNCT
fnp-3910	189	62	.	.	PUNCT
fnp-3910	190	1	in	in	ADP
fnp-3910	190	2	addition	addition	NOUN
fnp-3910	190	3	,	,	PUNCT
fnp-3910	190	4	they	they	PRON
fnp-3910	190	5	delivered	deliver	VERB
fnp-3910	190	6	lentiviral	lentiviral	ADJ
fnp-3910	190	7	mouse	mouse	NOUN
fnp-3910	190	8	tert	tert	NOUN
fnp-3910	190	9	(	(	PUNCT
fnp-3910	190	10	mtert	mtert	NOUN
fnp-3910	190	11	)	)	PUNCT
fnp-3910	190	12	to	to	PART
fnp-3910	190	13	hgps	hgps	NOUN
fnp-3910	190	14	mice	mouse	NOUN
fnp-3910	190	15	,	,	PUNCT
fnp-3910	190	16	and	and	CCONJ
fnp-3910	190	17	found	find	VERB
fnp-3910	190	18	that	that	SCONJ
fnp-3910	190	19	the	the	DET
fnp-3910	190	20	aorta	aorta	NOUN
fnp-3910	190	21	of	of	ADP
fnp-3910	190	22	treated	treat	VERB
fnp-3910	190	23	mtert	mtert	NOUN
fnp-3910	190	24	mice	mouse	NOUN
fnp-3910	190	25	showed	show	VERB
fnp-3910	190	26	reduced	reduced	ADJ
fnp-3910	190	27	levels	level	NOUN
fnp-3910	190	28	of	of	ADP
fnp-3910	190	29	vcam-1	vcam-1	NOUN
fnp-3910	190	30	expression	expression	NOUN
fnp-3910	190	31	(	(	PUNCT
fnp-3910	190	32	an	an	DET
fnp-3910	190	33	endothelial	endothelial	ADJ
fnp-3910	190	34	adhesion	adhesion	NOUN
fnp-3910	190	35	molecule	molecule	NOUN
fnp-3910	190	36	that	that	PRON
fnp-3910	190	37	is	be	AUX
fnp-3910	190	38	increased	increase	VERB
fnp-3910	190	39	with	with	ADP
fnp-3910	190	40	vascular	vascular	ADJ
fnp-3910	190	41	inflammation	inflammation	NOUN
fnp-3910	190	42	)	)	PUNCT
fnp-3910	190	43	,	,	PUNCT
fnp-3910	190	44	compared	compare	VERB
fnp-3910	190	45	with	with	ADP
fnp-3910	190	46	control	control	NOUN
fnp-3910	190	47	progeroid	progeroid	PROPN
fnp-3910	190	48	mice	mouse	NOUN
fnp-3910	190	49	.	.	PUNCT
fnp-3910	191	1	these	these	DET
fnp-3910	191	2	treated	treat	VERB
fnp-3910	191	3	mice	mouse	NOUN
fnp-3910	191	4	also	also	ADV
fnp-3910	191	5	exhibited	exhibit	VERB
fnp-3910	191	6	reduced	reduce	VERB
fnp-3910	191	7	dna	dna	ADJ
fnp-3910	191	8	damages	damage	NOUN
fnp-3910	191	9	in	in	ADP
fnp-3910	191	10	the	the	DET
fnp-3910	191	11	endothelium	endothelium	NOUN
fnp-3910	191	12	of	of	ADP
fnp-3910	191	13	different	different	ADJ
fnp-3910	191	14	tissues	tissue	NOUN
fnp-3910	191	15	(	(	PUNCT
fnp-3910	191	16	aorta	aorta	NOUN
fnp-3910	191	17	,	,	PUNCT
fnp-3910	191	18	lung	lung	NOUN
fnp-3910	191	19	,	,	PUNCT
fnp-3910	191	20	and	and	CCONJ
fnp-3910	191	21	liver	liver	NOUN
fnp-3910	191	22	)	)	PUNCT
fnp-3910	191	23	,	,	PUNCT
fnp-3910	191	24	and	and	CCONJ
fnp-3910	191	25	their	their	PRON
fnp-3910	191	26	lifespan	lifespan	NOUN
fnp-3910	191	27	were	be	AUX
fnp-3910	191	28	significantly	significantly	ADV
fnp-3910	191	29	extended	extend	VERB
fnp-3910	191	30	,	,	PUNCT
fnp-3910	191	31	compared	compare	VERB
fnp-3910	191	32	with	with	ADP
fnp-3910	191	33	hgps	hgp	NOUN
fnp-3910	191	34	mice	mouse	NOUN
fnp-3910	191	35	.	.	PUNCT
fnp-3910	192	1	this	this	DET
fnp-3910	192	2	study	study	NOUN
fnp-3910	192	3	demonstrates	demonstrate	VERB
fnp-3910	192	4	that	that	SCONJ
fnp-3910	192	5	tert	tert	NOUN
fnp-3910	192	6	treatment	treatment	NOUN
fnp-3910	192	7	restores	restore	VERB
fnp-3910	192	8	senescence	senescence	NOUN
fnp-3910	192	9	-	-	PUNCT
fnp-3910	192	10	associated	associate	VERB
fnp-3910	192	11	phenotype	phenotype	NOUN
fnp-3910	192	12	in	in	ADP
fnp-3910	192	13	human	human	ADJ
fnp-3910	192	14	hgps	hgps	NOUN
fnp-3910	192	15	endothelial	endothelial	NOUN
fnp-3910	192	16	cells	cell	NOUN
fnp-3910	192	17	,	,	PUNCT
fnp-3910	192	18	and	and	CCONJ
fnp-3910	192	19	expands	expand	VERB
fnp-3910	192	20	life	life	NOUN
fnp-3910	192	21	expectancy	expectancy	NOUN
fnp-3910	192	22	in	in	ADP
fnp-3910	192	23	a	a	DET
fnp-3910	192	24	mouse	mouse	NOUN
fnp-3910	192	25	model	model	NOUN
fnp-3910	192	26	of	of	ADP
fnp-3910	192	27	accelerated	accelerated	ADJ
fnp-3910	192	28	aging	aging	NOUN
fnp-3910	192	29	.	.	PUNCT
fnp-3910	193	1	its	its	PRON
fnp-3910	193	2	relevance	relevance	NOUN
fnp-3910	193	3	lies	lie	VERB
fnp-3910	193	4	in	in	ADP
fnp-3910	193	5	the	the	DET
fnp-3910	193	6	importance	importance	NOUN
fnp-3910	193	7	of	of	ADP
fnp-3910	193	8	specifically	specifically	ADV
fnp-3910	193	9	targeting	target	VERB
fnp-3910	193	10	the	the	DET
fnp-3910	193	11	endothelium	endothelium	NOUN
fnp-3910	193	12	to	to	PART
fnp-3910	193	13	prevent	prevent	VERB
fnp-3910	193	14	vascular	vascular	ADJ
fnp-3910	193	15	aging	aging	NOUN
fnp-3910	193	16	and	and	CCONJ
fnp-3910	193	17	mitigates	mitigate	VERB
fnp-3910	193	18	cardiovascular	cardiovascular	ADJ
fnp-3910	193	19	disease	disease	NOUN
fnp-3910	193	20	associated	associate	VERB
fnp-3910	193	21	with	with	ADP
fnp-3910	193	22	aging	age	VERB
fnp-3910	193	23	.	.	PUNCT
fnp-3910	194	1	figure	figure	NOUN
fnp-3910	194	2	4	4	NUM
fnp-3910	194	3	.	.	PUNCT
fnp-3910	194	4	telomerase	telomerase	NOUN
fnp-3910	194	5	(	(	PUNCT
fnp-3910	194	6	tert	tert	NOUN
fnp-3910	194	7	)	)	PUNCT
fnp-3910	194	8	therapy	therapy	NOUN
fnp-3910	194	9	reverses	reverse	VERB
fnp-3910	194	10	senescence	senescence	NOUN
fnp-3910	194	11	-	-	PUNCT
fnp-3910	194	12	associated	associate	VERB
fnp-3910	194	13	phenotypes	phenotype	NOUN
fnp-3910	194	14	in	in	ADP
fnp-3910	194	15	endothelial	endothelial	ADJ
fnp-3910	194	16	cells	cell	NOUN
fnp-3910	194	17	differentiated	differentiate	VERB
fnp-3910	194	18	from	from	ADP
fnp-3910	194	19	hutchinson	hutchinson	PROPN
fnp-3910	194	20	-	-	PUNCT
fnp-3910	194	21	gilford	gilford	PROPN
fnp-3910	194	22	(	(	PUNCT
fnp-3910	194	23	hgps	hgps	PROPN
fnp-3910	194	24	)	)	PUNCT
fnp-3910	194	25	human	human	PROPN
fnp-3910	194	26	ipsc	ipsc	PROPN
fnp-3910	194	27	lines	line	NOUN
fnp-3910	194	28	and	and	CCONJ
fnp-3910	194	29	in	in	ADP
fnp-3910	194	30	a	a	DET
fnp-3910	194	31	hgps	hgps	NOUN
fnp-3910	194	32	mouse	mouse	NOUN
fnp-3910	194	33	model	model	NOUN
fnp-3910	194	34	.	.	PUNCT
fnp-3910	195	1	human	human	ADJ
fnp-3910	195	2	tert	tert	NOUN
fnp-3910	195	3	(	(	PUNCT
fnp-3910	195	4	htert	htert	PROPN
fnp-3910	195	5	)	)	PUNCT
fnp-3910	195	6	mrna	mrna	PROPN
fnp-3910	195	7	was	be	AUX
fnp-3910	195	8	delivered	deliver	VERB
fnp-3910	195	9	into	into	ADP
fnp-3910	195	10	hipsc	hipsc	NOUN
fnp-3910	195	11	-	-	PUNCT
fnp-3910	195	12	derived	derive	VERB
fnp-3910	195	13	(	(	PUNCT
fnp-3910	195	14	control	control	NOUN
fnp-3910	195	15	and	and	CCONJ
fnp-3910	195	16	hgps	hgps	NOUN
fnp-3910	195	17	)	)	PUNCT
fnp-3910	195	18	endothelial	endothelial	ADJ
fnp-3910	195	19	cells	cell	NOUN
fnp-3910	195	20	by	by	ADP
fnp-3910	195	21	lipofectamine	lipofectamine	ADJ
fnp-3910	195	22	transfection	transfection	NOUN
fnp-3910	195	23	,	,	PUNCT
fnp-3910	195	24	and	and	CCONJ
fnp-3910	195	25	mouse	mouse	NOUN
fnp-3910	195	26	tert	tert	NOUN
fnp-3910	195	27	(	(	PUNCT
fnp-3910	195	28	mtert	mtert	NOUN
fnp-3910	195	29	)	)	PUNCT
fnp-3910	195	30	lentivirus	lentivirus	PROPN
fnp-3910	195	31	construct	construct	NOUN
fnp-3910	195	32	was	be	AUX
fnp-3910	195	33	injected	inject	VERB
fnp-3910	195	34	in	in	ADP
fnp-3910	195	35	3	3	NUM
fnp-3910	195	36	and	and	CCONJ
fnp-3910	195	37	6	6	NUM
fnp-3910	195	38	months	month	NOUN
fnp-3910	195	39	old	old	ADJ
fnp-3910	195	40	wild	wild	ADJ
fnp-3910	195	41	-	-	PUNCT
fnp-3910	195	42	type	type	NOUN
fnp-3910	195	43	and	and	CCONJ
fnp-3910	195	44	hgps	hgps	NOUN
fnp-3910	195	45	mice	mouse	NOUN
fnp-3910	195	46	via	via	ADP
fnp-3910	195	47	tail	tail	NOUN
fnp-3910	195	48	vein	vein	NOUN
fnp-3910	195	49	.	.	PUNCT
fnp-3910	196	1	created	create	VERB
fnp-3910	196	2	with	with	ADP
fnp-3910	196	3	biorender.com	biorender.com	X
fnp-3910	196	4	.	.	PUNCT
fnp-3910	196	5	topic	topic	NOUN
fnp-3910	196	6	10	10	NUM
fnp-3910	196	7	:	:	PUNCT
fnp-3910	196	8	brain	brain	NOUN
fnp-3910	196	9	capillary	capillary	ADJ
fnp-3910	196	10	pericytes	pericyte	NOUN
fnp-3910	196	11	exert	exert	VERB
fnp-3910	196	12	a	a	DET
fnp-3910	196	13	substantial	substantial	ADJ
fnp-3910	196	14	but	but	CCONJ
fnp-3910	196	15	slow	slow	ADJ
fnp-3910	196	16	influence	influence	NOUN
fnp-3910	196	17	on	on	ADP
fnp-3910	196	18	blood	blood	NOUN
fnp-3910	196	19	flow	flow	VERB
fnp-3910	196	20	the	the	DET
fnp-3910	196	21	role	role	NOUN
fnp-3910	196	22	of	of	ADP
fnp-3910	196	23	capillary	capillary	ADJ
fnp-3910	196	24	pericytes	pericyte	NOUN
fnp-3910	196	25	,	,	PUNCT
fnp-3910	196	26	cells	cell	NOUN
fnp-3910	196	27	that	that	PRON
fnp-3910	196	28	line	line	VERB
fnp-3910	196	29	the	the	DET
fnp-3910	196	30	capillary	capillary	ADJ
fnp-3910	196	31	networks	network	NOUN
fnp-3910	196	32	in	in	ADP
fnp-3910	196	33	the	the	DET
fnp-3910	196	34	brain	brain	NOUN
fnp-3910	196	35	,	,	PUNCT
fnp-3910	196	36	on	on	ADP
fnp-3910	196	37	cerebral	cerebral	ADJ
fnp-3910	196	38	blood	blood	NOUN
fnp-3910	196	39	flow	flow	NOUN
fnp-3910	196	40	was	be	AUX
fnp-3910	196	41	investigated	investigate	VERB
fnp-3910	196	42	in	in	ADP
fnp-3910	196	43	this	this	DET
fnp-3910	196	44	work	work	NOUN
fnp-3910	196	45	from	from	ADP
fnp-3910	196	46	dr	dr	PROPN
fnp-3910	196	47	.	.	PROPN
fnp-3910	196	48	shih	shih	PROPN
fnp-3910	196	49	’s	’s	PROPN
fnp-3910	196	50	group	group	NOUN
fnp-3910	196	51	(	(	PUNCT
fnp-3910	196	52	12	12	NUM
fnp-3910	196	53	)	)	PUNCT
fnp-3910	196	54	.	.	PUNCT
fnp-3910	197	1	the	the	DET
fnp-3910	197	2	capillary	capillary	ADJ
fnp-3910	197	3	bed	bed	NOUN
fnp-3910	197	4	has	have	VERB
fnp-3910	197	5	the	the	DET
fnp-3910	197	6	highest	high	ADJ
fnp-3910	197	7	flow	flow	NOUN
fnp-3910	197	8	resistance	resistance	NOUN
fnp-3910	197	9	in	in	ADP
fnp-3910	197	10	the	the	DET
fnp-3910	197	11	cerebral	cerebral	ADJ
fnp-3910	197	12	vasculature	vasculature	NOUN
fnp-3910	197	13	given	give	VERB
fnp-3910	197	14	their	their	PRON
fnp-3910	197	15	small	small	ADJ
fnp-3910	197	16	diameter	diameter	NOUN
fnp-3910	197	17	,	,	PUNCT
fnp-3910	197	18	and	and	CCONJ
fnp-3910	197	19	these	these	DET
fnp-3910	197	20	vessels	vessel	NOUN
fnp-3910	197	21	are	be	AUX
fnp-3910	197	22	lined	line	VERB
fnp-3910	197	23	with	with	ADP
fnp-3910	197	24	pericytes	pericyte	NOUN
fnp-3910	197	25	,	,	PUNCT
fnp-3910	197	26	unlike	unlike	ADP
fnp-3910	197	27	the	the	DET
fnp-3910	197	28	larger	large	ADJ
fnp-3910	197	29	arterioles	arteriole	NOUN
fnp-3910	197	30	of	of	ADP
fnp-3910	197	31	the	the	DET
fnp-3910	197	32	brain	brain	NOUN
fnp-3910	197	33	in	in	ADP
fnp-3910	197	34	which	which	PRON
fnp-3910	197	35	neurovascular	neurovascular	ADJ
fnp-3910	197	36	coupling	coupling	NOUN
fnp-3910	197	37	is	be	AUX
fnp-3910	197	38	controlled	control	VERB
fnp-3910	197	39	largely	largely	ADV
fnp-3910	197	40	by	by	ADP
fnp-3910	197	41	smooth	smooth	ADJ
fnp-3910	197	42	muscle	muscle	NOUN
fnp-3910	197	43	cells	cell	NOUN
fnp-3910	197	44	due	due	ADJ
fnp-3910	197	45	to	to	ADP
fnp-3910	197	46	rapid	rapid	ADJ
fnp-3910	197	47	blood	blood	NOUN
fnp-3910	197	48	flow	flow	NOUN
fnp-3910	197	49	demand	demand	NOUN
fnp-3910	197	50	and	and	CCONJ
fnp-3910	197	51	consist	consist	VERB
fnp-3910	197	52	of	of	ADP
fnp-3910	197	53	α	α	NOUN
fnp-3910	197	54	-	-	PUNCT
fnp-3910	197	55	sma	sma	NOUN
fnp-3910	197	56	-	-	PUNCT
fnp-3910	197	57	positive	positive	ADJ
fnp-3910	197	58	mural	mural	ADJ
fnp-3910	197	59	cells	cell	NOUN
fnp-3910	197	60	.	.	PUNCT
fnp-3910	198	1	two	two	NUM
fnp-3910	198	2	-	-	PUNCT
fnp-3910	198	3	photon	photon	NOUN
fnp-3910	198	4	microscopy	microscopy	NOUN
fnp-3910	198	5	and	and	CCONJ
fnp-3910	198	6	optogenetic	optogenetic	ADJ
fnp-3910	198	7	stimulation	stimulation	NOUN
fnp-3910	198	8	was	be	AUX
fnp-3910	198	9	used	use	VERB
fnp-3910	198	10	to	to	PART
fnp-3910	198	11	directly	directly	ADV
fnp-3910	198	12	observe	observe	VERB
fnp-3910	198	13	and	and	CCONJ
fnp-3910	198	14	manipulate	manipulate	VERB
fnp-3910	198	15	brain	brain	NOUN
fnp-3910	198	16	capillary	capillary	ADJ
fnp-3910	198	17	pericytes	pericyte	NOUN
fnp-3910	198	18	in	in	ADP
fnp-3910	198	19	vivo	vivo	NOUN
fnp-3910	198	20	.	.	PUNCT
fnp-3910	199	1	to	to	PART
fnp-3910	199	2	directly	directly	ADV
fnp-3910	199	3	assess	assess	VERB
fnp-3910	199	4	the	the	DET
fnp-3910	199	5	contractile	contractile	NOUN
fnp-3910	199	6	ability	ability	NOUN
fnp-3910	199	7	of	of	ADP
fnp-3910	199	8	capillary	capillary	ADJ
fnp-3910	199	9	pericytes	pericyte	NOUN
fnp-3910	199	10	in	in	ADP
fnp-3910	199	11	vivo	vivo	NOUN
fnp-3910	199	12	,	,	PUNCT
fnp-3910	199	13	the	the	DET
fnp-3910	199	14	authors	author	NOUN
fnp-3910	199	15	crossed	cross	VERB
fnp-3910	199	16	pdgfrβ	pdgfrβ	NOUN
fnp-3910	199	17	-	-	PUNCT
fnp-3910	199	18	cre	cre	PROPN
fnp-3910	199	19	mice	mouse	NOUN
fnp-3910	199	20	with	with	ADP
fnp-3910	199	21	reporter	reporter	NOUN
fnp-3910	199	22	mice	mouse	NOUN
fnp-3910	199	23	for	for	ADP
fnp-3910	199	24	the	the	DET
fnp-3910	199	25	light	light	ADJ
fnp-3910	199	26	-	-	PUNCT
fnp-3910	199	27	gated	gate	VERB
fnp-3910	199	28	ion	ion	NOUN
fnp-3910	199	29	channel	channel	NOUN
fnp-3910	199	30	,	,	PUNCT
fnp-3910	199	31	chr2	chr2	NOUN
fnp-3910	199	32	-	-	PUNCT
fnp-3910	199	33	yfp	yfp	NOUN
fnp-3910	199	34	.	.	PUNCT
fnp-3910	200	1	the	the	DET
fnp-3910	200	2	authors	author	NOUN
fnp-3910	200	3	confirmed	confirm	VERB
fnp-3910	200	4	that	that	SCONJ
fnp-3910	200	5	these	these	DET
fnp-3910	200	6	cells	cell	NOUN
fnp-3910	200	7	,	,	PUNCT
fnp-3910	200	8	when	when	SCONJ
fnp-3910	200	9	stimulated	stimulate	VERB
fnp-3910	200	10	optogenetically	optogenetically	ADV
fnp-3910	200	11	,	,	PUNCT
fnp-3910	200	12	can	can	AUX
fnp-3910	200	13	contract	contract	VERB
fnp-3910	200	14	,	,	PUNCT
fnp-3910	200	15	decreasing	decrease	VERB
fnp-3910	200	16	their	their	PRON
fnp-3910	200	17	luminal	luminal	ADJ
fnp-3910	200	18	diameter	diameter	NOUN
fnp-3910	200	19	and	and	CCONJ
fnp-3910	200	20	reduce	reduce	VERB
fnp-3910	200	21	blood	blood	NOUN
fnp-3910	200	22	flow	flow	NOUN
fnp-3910	200	23	,	,	PUNCT
fnp-3910	200	24	but	but	CCONJ
fnp-3910	200	25	with	with	ADP
fnp-3910	200	26	slower	slow	ADJ
fnp-3910	200	27	kinetics	kinetic	NOUN
fnp-3910	200	28	than	than	ADP
fnp-3910	200	29	similar	similar	ADJ
fnp-3910	200	30	stimulation	stimulation	NOUN
fnp-3910	200	31	of	of	ADP
fnp-3910	200	32	mural	mural	ADJ
fnp-3910	200	33	cells	cell	NOUN
fnp-3910	200	34	on	on	ADP
fnp-3910	200	35	upstream	upstream	ADJ
fnp-3910	200	36	pial	pial	ADJ
fnp-3910	200	37	and	and	CCONJ
fnp-3910	200	38	precapillary	precapillary	ADJ
fnp-3910	200	39	arterioles	arteriole	NOUN
fnp-3910	200	40	.	.	PUNCT
fnp-3910	201	1	importantly	importantly	ADV
fnp-3910	201	2	,	,	PUNCT
fnp-3910	201	3	this	this	DET
fnp-3910	201	4	vasoconstriction	vasoconstriction	NOUN
fnp-3910	201	5	was	be	AUX
fnp-3910	201	6	associated	associate	VERB
fnp-3910	201	7	with	with	ADP
fnp-3910	201	8	a	a	DET
fnp-3910	201	9	decrease	decrease	NOUN
fnp-3910	201	10	in	in	ADP
fnp-3910	201	11	red	red	ADJ
fnp-3910	201	12	blood	blood	NOUN
fnp-3910	201	13	cell	cell	NOUN
fnp-3910	201	14	velocity	velocity	NOUN
fnp-3910	201	15	and	and	CCONJ
fnp-3910	201	16	flux	flux	NOUN
fnp-3910	201	17	in	in	ADP
fnp-3910	201	18	the	the	DET
fnp-3910	201	19	same	same	ADJ
fnp-3910	201	20	capillaries	capillary	NOUN
fnp-3910	201	21	,	,	PUNCT
fnp-3910	201	22	showing	show	VERB
fnp-3910	201	23	that	that	SCONJ
fnp-3910	201	24	the	the	DET
fnp-3910	201	25	induced	induced	ADJ
fnp-3910	201	26	levels	level	NOUN
fnp-3910	201	27	of	of	ADP
fnp-3910	201	28	constriction	constriction	NOUN
fnp-3910	201	29	were	be	AUX
fnp-3910	201	30	sufficient	sufficient	ADJ
fnp-3910	201	31	to	to	PART
fnp-3910	201	32	alter	alter	VERB
fnp-3910	201	33	blood	blood	NOUN
fnp-3910	201	34	flow	flow	NOUN
fnp-3910	201	35	,	,	PUNCT
fnp-3910	201	36	and	and	CCONJ
fnp-3910	201	37	in	in	ADP
fnp-3910	201	38	fact	fact	NOUN
fnp-3910	201	39	led	lead	VERB
fnp-3910	201	40	to	to	ADP
fnp-3910	201	41	significant	significant	ADJ
fnp-3910	201	42	“	"	PUNCT
fnp-3910	201	43	stalling	stalling	NOUN
fnp-3910	201	44	”	"	PUNCT
fnp-3910	201	45	of	of	ADP
fnp-3910	201	46	rbc	rbc	PROPN
fnp-3910	201	47	flow	flow	NOUN
fnp-3910	201	48	.	.	PUNCT
fnp-3910	202	1	interestingly	interestingly	ADV
fnp-3910	202	2	,	,	PUNCT
fnp-3910	202	3	“	"	PUNCT
fnp-3910	202	4	blebs	blebs	NOUN
fnp-3910	202	5	”	"	PUNCT
fnp-3910	202	6	were	be	AUX
fnp-3910	202	7	seen	see	VERB
fnp-3910	202	8	in	in	ADP
fnp-3910	202	9	up	up	ADP
fnp-3910	202	10	to	to	PART
fnp-3910	202	11	30	30	NUM
fnp-3910	202	12	%	%	NOUN
fnp-3910	202	13	of	of	ADP
fnp-3910	202	14	the	the	DET
fnp-3910	202	15	pericytes	pericyte	NOUN
fnp-3910	202	16	.	.	PUNCT
fnp-3910	203	1	the	the	DET
fnp-3910	203	2	authors	author	NOUN
fnp-3910	203	3	hypothesized	hypothesize	VERB
fnp-3910	203	4	that	that	SCONJ
fnp-3910	203	5	these	these	DET
fnp-3910	203	6	blebs	blebs	NOUN
fnp-3910	203	7	reflected	reflect	VERB
fnp-3910	203	8	disruption	disruption	NOUN
fnp-3910	203	9	of	of	ADP
fnp-3910	203	10	the	the	DET
fnp-3910	203	11	actin	actin	NOUN
fnp-3910	203	12	cytoskeleton	cytoskeleton	PROPN
fnp-3910	203	13	due	due	ADP
fnp-3910	203	14	to	to	ADP
fnp-3910	203	15	induced	induce	VERB
fnp-3910	203	16	supra	supra	ADJ
fnp-3910	203	17	-	-	PUNCT
fnp-3910	203	18	physiological	physiological	ADJ
fnp-3910	203	19	contraction	contraction	NOUN
fnp-3910	203	20	.	.	PUNCT
fnp-3910	204	1	this	this	DET
fnp-3910	204	2	slow	slow	ADJ
fnp-3910	204	3	vasoconstriction	vasoconstriction	NOUN
fnp-3910	204	4	was	be	AUX
fnp-3910	204	5	inhibited	inhibit	VERB
fnp-3910	204	6	by	by	ADP
fnp-3910	204	7	the	the	DET
fnp-3910	204	8	clinically	clinically	ADV
fnp-3910	204	9	used	use	VERB
fnp-3910	204	10	vasodilator	vasodilator	NOUN
fnp-3910	204	11	fasudil	fasudil	NOUN
fnp-3910	204	12	,	,	PUNCT
fnp-3910	204	13	a	a	DET
fnp-3910	204	14	rho	rho	ADJ
fnp-3910	204	15	-	-	ADJ
fnp-3910	204	16	kinase	kinase	ADJ
fnp-3910	204	17	inhibitor	inhibitor	NOUN
fnp-3910	204	18	that	that	PRON
fnp-3910	204	19	blocks	block	VERB
fnp-3910	204	20	contractile	contractile	ADJ
fnp-3910	204	21	machinery	machinery	NOUN
fnp-3910	204	22	and	and	CCONJ
fnp-3910	204	23	promotes	promote	VERB
fnp-3910	204	24	vasodilation	vasodilation	NOUN
fnp-3910	204	25	.	.	PUNCT
fnp-3910	205	1	during	during	ADP
fnp-3910	205	2	optogenetic	optogenetic	ADJ
fnp-3910	205	3	stimulation	stimulation	NOUN
fnp-3910	205	4	of	of	ADP
fnp-3910	205	5	capillary	capillary	ADJ
fnp-3910	205	6	pericytes	pericyte	NOUN
fnp-3910	205	7	,	,	PUNCT
fnp-3910	205	8	fasudil	fasudil	NOUN
fnp-3910	205	9	attenuated	attenuate	VERB
fnp-3910	205	10	relative	relative	ADJ
fnp-3910	205	11	and	and	CCONJ
fnp-3910	205	12	absolute	absolute	ADJ
fnp-3910	205	13	capillary	capillary	ADJ
fnp-3910	205	14	constriction	constriction	NOUN
fnp-3910	205	15	in	in	ADP
fnp-3910	205	16	a	a	DET
fnp-3910	205	17	dose	dose	NOUN
fnp-3910	205	18	-	-	PUNCT
fnp-3910	205	19	dependent	dependent	ADJ
fnp-3910	205	20	manner	manner	NOUN
fnp-3910	205	21	and	and	CCONJ
fnp-3910	205	22	also	also	ADV
fnp-3910	205	23	led	lead	VERB
fnp-3910	205	24	to	to	ADP
fnp-3910	205	25	a	a	DET
fnp-3910	205	26	dose	dose	NOUN
fnp-3910	205	27	-	-	PUNCT
fnp-3910	205	28	dependent	dependent	ADJ
fnp-3910	205	29	alleviation	alleviation	NOUN
fnp-3910	205	30	of	of	ADP
fnp-3910	205	31	persistent	persistent	ADJ
fnp-3910	205	32	flow	flow	NOUN
fnp-3910	205	33	stalls	stall	NOUN
fnp-3910	205	34	.	.	PUNCT
fnp-3910	206	1	this	this	PRON
fnp-3910	206	2	has	have	VERB
fnp-3910	206	3	important	important	ADJ
fnp-3910	206	4	translational	translational	ADJ
fnp-3910	206	5	relevance	relevance	NOUN
fnp-3910	206	6	as	as	SCONJ
fnp-3910	206	7	this	this	DET
fnp-3910	206	8	drug	drug	NOUN
fnp-3910	206	9	is	be	AUX
fnp-3910	206	10	used	use	VERB
fnp-3910	206	11	to	to	PART
fnp-3910	206	12	treat	treat	VERB
fnp-3910	206	13	cerebral	cerebral	ADJ
fnp-3910	206	14	vasospasm	vasospasm	NOUN
fnp-3910	206	15	after	after	SCONJ
fnp-3910	206	16	subarachnoid	subarachnoid	VERB
fnp-3910	206	17	hemorrhage	hemorrhage	NOUN
fnp-3910	206	18	in	in	ADP
fnp-3910	206	19	japan	japan	PROPN
fnp-3910	206	20	,	,	PUNCT
fnp-3910	206	21	and	and	CCONJ
fnp-3910	206	22	could	could	AUX
fnp-3910	206	23	have	have	VERB
fnp-3910	206	24	a	a	DET
fnp-3910	206	25	role	role	NOUN
fnp-3910	206	26	in	in	ADP
fnp-3910	206	27	preventing	prevent	VERB
fnp-3910	206	28	the	the	DET
fnp-3910	206	29	no	no	DET
fnp-3910	206	30	reflow	reflow	NOUN
fnp-3910	206	31	phenomenon	phenomenon	NOUN
fnp-3910	206	32	in	in	ADP
fnp-3910	206	33	ischemic	ischemic	ADJ
fnp-3910	206	34	stroke	stroke	NOUN
fnp-3910	206	35	after	after	ADP
fnp-3910	206	36	endovascular	endovascular	ADJ
fnp-3910	206	37	interventions	intervention	NOUN
fnp-3910	206	38	.	.	PUNCT
fnp-3910	207	1	capillary	capillary	ADJ
fnp-3910	207	2	pericytes	pericyte	NOUN
fnp-3910	207	3	were	be	AUX
fnp-3910	207	4	also	also	ADV
fnp-3910	207	5	slower	slow	ADJ
fnp-3910	207	6	to	to	PART
fnp-3910	207	7	constrict	constrict	VERB
fnp-3910	207	8	back	back	ADV
fnp-3910	207	9	to	to	ADP
fnp-3910	207	10	baseline	baseline	VERB
fnp-3910	207	11	following	follow	VERB
fnp-3910	207	12	hypercapnia	hypercapnia	NOUN
fnp-3910	207	13	-	-	PUNCT
fnp-3910	207	14	induced	induce	VERB
fnp-3910	207	15	dilation	dilation	NOUN
fnp-3910	207	16	,	,	PUNCT
fnp-3910	207	17	and	and	CCONJ
fnp-3910	207	18	slower	slow	ADJ
fnp-3910	207	19	to	to	PART
fnp-3910	207	20	dilate	dilate	VERB
fnp-3910	207	21	towards	towards	ADP
fnp-3910	207	22	baseline	baseline	NOUN
fnp-3910	207	23	following	follow	VERB
fnp-3910	207	24	optogenetically	optogenetically	ADV
fnp-3910	207	25	induced	induce	VERB
fnp-3910	207	26	vasoconstriction	vasoconstriction	NOUN
fnp-3910	207	27	compared	compare	VERB
fnp-3910	207	28	to	to	ADP
fnp-3910	207	29	pre	pre	ADJ
fnp-3910	207	30	-	-	ADJ
fnp-3910	207	31	capillary	capillary	ADJ
fnp-3910	207	32	arterioles	arteriole	NOUN
fnp-3910	207	33	.	.	PUNCT
fnp-3910	208	1	optical	optical	ADJ
fnp-3910	208	2	ablation	ablation	NOUN
fnp-3910	208	3	of	of	ADP
fnp-3910	208	4	single	single	ADJ
fnp-3910	208	5	capillary	capillary	ADJ
fnp-3910	208	6	pericytes	pericyte	NOUN
fnp-3910	208	7	led	lead	VERB
fnp-3910	208	8	to	to	ADP
fnp-3910	208	9	sustained	sustain	VERB
fnp-3910	208	10	local	local	ADJ
fnp-3910	208	11	dilation	dilation	NOUN
fnp-3910	208	12	and	and	CCONJ
fnp-3910	208	13	a	a	DET
fnp-3910	208	14	doubling	doubling	NOUN
fnp-3910	208	15	of	of	ADP
fnp-3910	208	16	blood	blood	NOUN
fnp-3910	208	17	cell	cell	NOUN
fnp-3910	208	18	flux	flux	NOUN
fnp-3910	208	19	selectively	selectively	ADV
fnp-3910	208	20	in	in	ADP
fnp-3910	208	21	capillaries	capillary	NOUN
fnp-3910	208	22	lacking	lack	VERB
fnp-3910	208	23	pericyte	pericyte	NOUN
fnp-3910	208	24	contact	contact	NOUN
fnp-3910	208	25	.	.	PUNCT
fnp-3910	209	1	these	these	DET
fnp-3910	209	2	data	datum	NOUN
fnp-3910	209	3	indicate	indicate	VERB
fnp-3910	209	4	that	that	SCONJ
fnp-3910	209	5	capillary	capillary	ADJ
fnp-3910	209	6	pericytes	pericyte	NOUN
fnp-3910	209	7	contribute	contribute	VERB
fnp-3910	209	8	to	to	AUX
fnp-3910	209	9	basal	basal	VERB
fnp-3910	209	10	blood	blood	NOUN
fnp-3910	209	11	flow	flow	NOUN
fnp-3910	209	12	resistance	resistance	NOUN
fnp-3910	209	13	and	and	CCONJ
fnp-3910	209	14	slow	slow	ADJ
fnp-3910	209	15	modulation	modulation	NOUN
fnp-3910	209	16	of	of	ADP
fnp-3910	209	17	blood	blood	NOUN
fnp-3910	209	18	flow	flow	NOUN
fnp-3910	209	19	throughout	throughout	ADP
fnp-3910	209	20	the	the	DET
fnp-3910	209	21	brain	brain	NOUN
fnp-3910	209	22	.	.	PUNCT
fnp-3910	210	1	this	this	PRON
fnp-3910	210	2	could	could	AUX
fnp-3910	210	3	have	have	VERB
fnp-3910	210	4	major	major	ADJ
fnp-3910	210	5	implications	implication	NOUN
fnp-3910	210	6	for	for	ADP
fnp-3910	210	7	other	other	ADJ
fnp-3910	210	8	disorders	disorder	NOUN
fnp-3910	210	9	related	relate	VERB
fnp-3910	210	10	to	to	ADP
fnp-3910	210	11	cerebral	cerebral	ADJ
fnp-3910	210	12	hypoperfusion	hypoperfusion	NOUN
fnp-3910	210	13	.	.	PUNCT
fnp-3910	211	1	figure	figure	NOUN
fnp-3910	211	2	5	5	NUM
fnp-3910	211	3	.	.	PUNCT
fnp-3910	212	1	the	the	DET
fnp-3910	212	2	skull	skull	NOUN
fnp-3910	212	3	bone	bone	PROPN
fnp-3910	212	4	marrow	marrow	PROPN
fnp-3910	212	5	immune	immune	ADJ
fnp-3910	212	6	profile	profile	NOUN
fnp-3910	212	7	changes	change	NOUN
fnp-3910	212	8	with	with	ADP
fnp-3910	212	9	aging	aging	NOUN
fnp-3910	212	10	.	.	PUNCT
fnp-3910	213	1	the	the	DET
fnp-3910	213	2	composition	composition	NOUN
fnp-3910	213	3	of	of	ADP
fnp-3910	213	4	myeloid	myeloid	ADJ
fnp-3910	213	5	cell	cell	NOUN
fnp-3910	213	6	populations	population	NOUN
fnp-3910	213	7	in	in	ADP
fnp-3910	213	8	the	the	DET
fnp-3910	213	9	skull	skull	NOUN
fnp-3910	213	10	bone	bone	NOUN
fnp-3910	213	11	marrow	marrow	NOUN
fnp-3910	213	12	changes	change	VERB
fnp-3910	213	13	with	with	ADP
fnp-3910	213	14	aging	age	VERB
fnp-3910	213	15	with	with	ADP
fnp-3910	213	16	significantly	significantly	ADV
fnp-3910	213	17	higher	high	ADJ
fnp-3910	213	18	relative	relative	ADJ
fnp-3910	213	19	frequencies	frequency	NOUN
fnp-3910	213	20	of	of	ADP
fnp-3910	213	21	neutrophils	neutrophil	NOUN
fnp-3910	213	22	in	in	ADP
fnp-3910	213	23	aged	aged	ADJ
fnp-3910	213	24	skull	skull	NOUN
fnp-3910	213	25	(	(	PUNCT
fnp-3910	213	26	top	top	NOUN
fnp-3910	213	27	)	)	PUNCT
fnp-3910	213	28	.	.	PUNCT
fnp-3910	214	1	skull	skull	NOUN
fnp-3910	214	2	bone	bone	PROPN
fnp-3910	214	3	marrow	marrow	PROPN
fnp-3910	214	4	lymphocyte	lymphocyte	ADJ
fnp-3910	214	5	compartment	compartment	NOUN
fnp-3910	214	6	contains	contain	VERB
fnp-3910	214	7	significantly	significantly	ADV
fnp-3910	214	8	higher	high	ADJ
fnp-3910	214	9	cd8	cd8	PROPN
fnp-3910	214	10	+	+	PROPN
fnp-3910	214	11	t	t	PROPN
fnp-3910	214	12	lymphocytes	lymphocyte	NOUN
fnp-3910	214	13	and	and	CCONJ
fnp-3910	214	14	activated	activated	ADJ
fnp-3910	214	15	cd11b	cd11b	NOUN
fnp-3910	214	16	high	high	ADJ
fnp-3910	214	17	b	b	PROPN
fnp-3910	214	18	lymphocytes	lymphocyte	NOUN
fnp-3910	214	19	in	in	ADP
fnp-3910	214	20	naïve	naïve	ADJ
fnp-3910	214	21	aged	aged	ADJ
fnp-3910	214	22	mice	mouse	NOUN
fnp-3910	214	23	when	when	SCONJ
fnp-3910	214	24	compared	compare	VERB
fnp-3910	214	25	with	with	ADP
fnp-3910	214	26	young	young	ADJ
fnp-3910	214	27	skull	skull	NOUN
fnp-3910	214	28	(	(	PUNCT
fnp-3910	214	29	bottom	bottom	NOUN
fnp-3910	214	30	)	)	PUNCT
fnp-3910	214	31	.	.	PUNCT
fnp-3910	215	1	reprinted	reprint	VERB
fnp-3910	215	2	from	from	ADP
fnp-3910	215	3	honarpisheh	honarpisheh	PROPN
fnp-3910	215	4	et	et	PROPN
fnp-3910	215	5	al	al	PROPN
fnp-3910	215	6	.	.	PUNCT
fnp-3910	216	1	(	(	PUNCT
fnp-3910	216	2	13	13	NUM
fnp-3910	216	3	)	)	PUNCT
fnp-3910	216	4	.	.	PUNCT
fnp-3910	217	1	conclusion	conclusion	NOUN
fnp-3910	217	2	many	many	ADJ
fnp-3910	217	3	exciting	exciting	ADJ
fnp-3910	217	4	and	and	CCONJ
fnp-3910	217	5	novel	novel	ADJ
fnp-3910	217	6	papers	paper	NOUN
fnp-3910	217	7	were	be	AUX
fnp-3910	217	8	published	publish	VERB
fnp-3910	217	9	in	in	ADP
fnp-3910	217	10	2021	2021	NUM
fnp-3910	217	11	.	.	PUNCT
fnp-3910	218	1	the	the	DET
fnp-3910	218	2	compendium	compendium	NOUN
fnp-3910	218	3	of	of	ADP
fnp-3910	218	4	papers	paper	NOUN
fnp-3910	218	5	highlighted	highlight	VERB
fnp-3910	218	6	demonstrate	demonstrate	VERB
fnp-3910	218	7	our	our	PRON
fnp-3910	218	8	growing	grow	VERB
fnp-3910	218	9	understanding	understanding	NOUN
fnp-3910	218	10	of	of	ADP
fnp-3910	218	11	vascular	vascular	ADJ
fnp-3910	218	12	malformations	malformation	NOUN
fnp-3910	218	13	,	,	PUNCT
fnp-3910	218	14	neuro	neuro	NOUN
fnp-3910	218	15	-	-	PUNCT
fnp-3910	218	16	immune	immune	ADJ
fnp-3910	218	17	communication	communication	NOUN
fnp-3910	218	18	,	,	PUNCT
fnp-3910	218	19	and	and	CCONJ
fnp-3910	218	20	vascular	vascular	ADJ
fnp-3910	218	21	function	function	NOUN
fnp-3910	218	22	in	in	ADP
fnp-3910	218	23	aging	aging	NOUN
fnp-3910	218	24	and	and	CCONJ
fnp-3910	218	25	disease	disease	NOUN
fnp-3910	218	26	.	.	PUNCT
fnp-3910	219	1	one	one	NUM
fnp-3910	219	2	important	important	ADJ
fnp-3910	219	3	caveat	caveat	NOUN
fnp-3910	219	4	to	to	PART
fnp-3910	219	5	consider	consider	VERB
fnp-3910	219	6	is	be	AUX
fnp-3910	219	7	that	that	SCONJ
fnp-3910	219	8	many	many	ADJ
fnp-3910	219	9	of	of	ADP
fnp-3910	219	10	these	these	DET
fnp-3910	219	11	diseases	disease	NOUN
fnp-3910	219	12	predominately	predominately	ADV
fnp-3910	219	13	affect	affect	VERB
fnp-3910	219	14	older	old	ADJ
fnp-3910	219	15	individuals	individual	NOUN
fnp-3910	219	16	,	,	PUNCT
fnp-3910	219	17	such	such	ADJ
fnp-3910	219	18	as	as	ADP
fnp-3910	219	19	stroke	stroke	NOUN
fnp-3910	219	20	and	and	CCONJ
fnp-3910	219	21	amyloid	amyloid	NOUN
fnp-3910	219	22	related	relate	VERB
fnp-3910	219	23	diseases	disease	NOUN
fnp-3910	219	24	.	.	PUNCT
fnp-3910	220	1	as	as	SCONJ
fnp-3910	220	2	the	the	DET
fnp-3910	220	3	field	field	NOUN
fnp-3910	220	4	moves	move	VERB
fnp-3910	220	5	forward	forward	ADV
fnp-3910	220	6	it	it	PRON
fnp-3910	220	7	will	will	AUX
fnp-3910	220	8	be	be	AUX
fnp-3910	220	9	important	important	ADJ
fnp-3910	220	10	to	to	PART
fnp-3910	220	11	consider	consider	VERB
fnp-3910	220	12	the	the	DET
fnp-3910	220	13	age	age	NOUN
fnp-3910	220	14	of	of	ADP
fnp-3910	220	15	the	the	DET
fnp-3910	220	16	animals	animal	NOUN
fnp-3910	220	17	used	use	VERB
fnp-3910	220	18	,	,	PUNCT
fnp-3910	220	19	and	and	CCONJ
fnp-3910	220	20	also	also	ADV
fnp-3910	220	21	confirming	confirm	VERB
fnp-3910	220	22	that	that	SCONJ
fnp-3910	220	23	these	these	DET
fnp-3910	220	24	pathways	pathway	NOUN
fnp-3910	220	25	are	be	AUX
fnp-3910	220	26	involved	involve	VERB
fnp-3910	220	27	in	in	ADP
fnp-3910	220	28	human	human	ADJ
fnp-3910	220	29	disease	disease	NOUN
fnp-3910	220	30	using	use	VERB
fnp-3910	220	31	clinical	clinical	ADJ
fnp-3910	220	32	samples	sample	NOUN
fnp-3910	220	33	to	to	PART
fnp-3910	220	34	ensure	ensure	VERB
fnp-3910	220	35	translational	translational	ADJ
fnp-3910	220	36	relevance	relevance	NOUN
fnp-3910	220	37	.	.	PUNCT
fnp-3910	221	1	for	for	ADP
fnp-3910	221	2	example	example	NOUN
fnp-3910	221	3	,	,	PUNCT
fnp-3910	221	4	recent	recent	ADJ
fnp-3910	221	5	work	work	NOUN
fnp-3910	221	6	in	in	ADP
fnp-3910	221	7	our	our	PRON
fnp-3910	221	8	own	own	ADJ
fnp-3910	221	9	laboratory	laboratory	NOUN
fnp-3910	221	10	has	have	AUX
fnp-3910	221	11	shown	show	VERB
fnp-3910	221	12	that	that	SCONJ
fnp-3910	221	13	the	the	DET
fnp-3910	221	14	skull	skull	NOUN
fnp-3910	221	15	immune	immune	ADJ
fnp-3910	221	16	compartment	compartment	NOUN
fnp-3910	221	17	changes	change	NOUN
fnp-3910	221	18	dramatically	dramatically	ADV
fnp-3910	221	19	with	with	ADP
fnp-3910	221	20	age	age	NOUN
fnp-3910	221	21	(	(	PUNCT
fnp-3910	221	22	figure	figure	NOUN
fnp-3910	221	23	5	5	NUM
fnp-3910	221	24	)	)	PUNCT
fnp-3910	221	25	.	.	PUNCT
fnp-3910	222	1	age	age	NOUN
fnp-3910	222	2	-	-	PUNCT
fnp-3910	222	3	related	relate	VERB
fnp-3910	222	4	changes	change	NOUN
fnp-3910	222	5	in	in	ADP
fnp-3910	222	6	both	both	CCONJ
fnp-3910	222	7	peripheral	peripheral	ADJ
fnp-3910	222	8	and	and	CCONJ
fnp-3910	222	9	cns	cns	NOUN
fnp-3910	222	10	immunity	immunity	NOUN
fnp-3910	222	11	will	will	AUX
fnp-3910	222	12	be	be	AUX
fnp-3910	222	13	an	an	DET
fnp-3910	222	14	important	important	ADJ
fnp-3910	222	15	avenue	avenue	NOUN
fnp-3910	222	16	of	of	ADP
fnp-3910	222	17	exploration	exploration	NOUN
fnp-3910	222	18	in	in	ADP
fnp-3910	222	19	the	the	DET
fnp-3910	222	20	future	future	NOUN
fnp-3910	222	21	.	.	PUNCT
fnp-3910	223	1	acknowledgements	acknowledgement	NOUN
fnp-3910	223	2	i	i	PRON
fnp-3910	223	3	would	would	AUX
fnp-3910	223	4	like	like	VERB
fnp-3910	223	5	to	to	PART
fnp-3910	223	6	thank	thank	VERB
fnp-3910	223	7	felix	felix	PROPN
fnp-3910	223	8	moruno	moruno	PROPN
fnp-3910	223	9	manchon	manchon	NOUN
fnp-3910	223	10	,	,	PUNCT
fnp-3910	223	11	phd	phd	NOUN
fnp-3910	223	12	,	,	PUNCT
fnp-3910	223	13	juneyoung	juneyoung	PROPN
fnp-3910	223	14	lee	lee	PROPN
fnp-3910	223	15	,	,	PUNCT
fnp-3910	223	16	phd	phd	PROPN
fnp-3910	223	17	,	,	PUNCT
fnp-3910	223	18	pedram	pedram	NOUN
fnp-3910	223	19	honarpisheh	honarpisheh	NOUN
fnp-3910	223	20	,	,	PUNCT
fnp-3910	223	21	phd	phd	NOUN
fnp-3910	223	22	,	,	PUNCT
fnp-3910	223	23	aki	aki	PROPN
fnp-3910	223	24	urayama	urayama	PROPN
fnp-3910	223	25	,	,	PUNCT
fnp-3910	223	26	phd	phd	NOUN
fnp-3910	223	27	,	,	PUNCT
fnp-3910	223	28	sophie	sophie	PROPN
fnp-3910	223	29	ren	ren	PROPN
fnp-3910	223	30	,	,	PUNCT
fnp-3910	223	31	phd	phd	PROPN
fnp-3910	223	32	,	,	PUNCT
fnp-3910	223	33	alex	alex	PROPN
fnp-3910	223	34	choi	choi	PROPN
fnp-3910	223	35	,	,	PUNCT
fnp-3910	223	36	md	md	PROPN
fnp-3910	223	37	,	,	PUNCT
fnp-3910	223	38	and	and	CCONJ
fnp-3910	223	39	eunhee	eunhee	PROPN
fnp-3910	223	40	kim	kim	PROPN
fnp-3910	223	41	,	,	PUNCT
fnp-3910	223	42	phd	phd	PROPN
fnp-3910	223	43	,	,	PUNCT
fnp-3910	223	44	for	for	ADP
fnp-3910	223	45	their	their	PRON
fnp-3910	223	46	assistance	assistance	NOUN
fnp-3910	223	47	in	in	ADP
fnp-3910	223	48	selection	selection	NOUN
fnp-3910	223	49	of	of	ADP
fnp-3910	223	50	these	these	DET
fnp-3910	223	51	manuscripts	manuscript	NOUN
fnp-3910	223	52	.	.	PUNCT
fnp-3910	224	1	ldm	ldm	NOUN
fnp-3910	224	2	is	be	AUX
fnp-3910	224	3	supported	support	VERB
fnp-3910	224	4	by	by	ADP
fnp-3910	224	5	the	the	DET
fnp-3910	224	6	national	national	PROPN
fnp-3910	224	7	institute	institute	PROPN
fnp-3910	224	8	of	of	ADP
fnp-3910	224	9	health	health	PROPN
fnp-3910	224	10	(	(	PUNCT
fnp-3910	224	11	nih	nih	PROPN
fnp-3910	224	12	)	)	PUNCT
fnp-3910	224	13	with	with	ADP
fnp-3910	224	14	grants	grant	NOUN
fnp-3910	224	15	from	from	ADP
fnp-3910	224	16	the	the	DET
fnp-3910	224	17	ninds	nind	NOUN
fnp-3910	224	18	(	(	PUNCT
fnp-3910	224	19	r37	r37	PROPN
fnp-3910	224	20	ns096493	ns096493	PROPN
fnp-3910	224	21	,	,	PUNCT
fnp-3910	224	22	r01	r01	PROPN
fnp-3910	224	23	ns108779	ns108779	PROPN
fnp-3910	224	24	)	)	PUNCT
fnp-3910	224	25	and	and	CCONJ
fnp-3910	224	26	nia	nia	PROPN
fnp-3910	224	27	(	(	PUNCT
fnp-3910	224	28	r01	r01	PROPN
fnp-3910	224	29	ns103592	ns103592	PROPN
fnp-3910	224	30	)	)	PUNCT
fnp-3910	224	31	.	.	PUNCT
fnp-3910	225	1	references	reference	NOUN
fnp-3910	225	2	nikolaev	nikolaev	ADV
fnp-3910	225	3	si	si	NOUN
fnp-3910	225	4	,	,	PUNCT
fnp-3910	225	5	fish	fish	PROPN
fnp-3910	225	6	je	je	PROPN
fnp-3910	225	7	,	,	PUNCT
fnp-3910	225	8	radovanovic	radovanovic	ADJ
fnp-3910	225	9	i.	i.	PROPN
fnp-3910	225	10	somatic	somatic	NOUN
fnp-3910	225	11	activating	activate	VERB
fnp-3910	225	12	kras	kra	NOUN
fnp-3910	225	13	mutations	mutation	NOUN
fnp-3910	225	14	in	in	ADP
fnp-3910	225	15	arteriovenous	arteriovenous	ADJ
fnp-3910	225	16	malformations	malformation	NOUN
fnp-3910	225	17	of	of	ADP
fnp-3910	225	18	the	the	DET
fnp-3910	225	19	brain	brain	NOUN
fnp-3910	225	20	.	.	PUNCT
fnp-3910	226	1	n	n	PROPN
fnp-3910	226	2	engl	engl	PROPN
fnp-3910	226	3	j	j	PROPN
fnp-3910	226	4	med	med	PROPN
fnp-3910	226	5	.	.	PUNCT
fnp-3910	227	1	2018	2018	NUM
fnp-3910	227	2	apr	apr	NOUN
fnp-3910	227	3	19;378(16):1561	19;378(16):1561	NUM
fnp-3910	227	4	-	-	PUNCT
fnp-3910	227	5	1562	1562	NUM
fnp-3910	227	6	.	.	PUNCT
fnp-3910	228	1	https://doi.org/10.1056/nejmc1802190	https://doi.org/10.1056/nejmc1802190	PROPN
fnp-3910	228	2	al	al	PROPN
fnp-3910	228	3	-	-	PUNCT
fnp-3910	228	4	olabi	olabi	PROPN
fnp-3910	228	5	l	l	PROPN
fnp-3910	228	6	,	,	PUNCT
fnp-3910	228	7	polubothu	polubothu	PROPN
fnp-3910	228	8	s	s	PROPN
fnp-3910	228	9	,	,	PUNCT
fnp-3910	228	10	dowsett	dowsett	PROPN
fnp-3910	228	11	k	k	PROPN
fnp-3910	228	12	,	,	PUNCT
fnp-3910	228	13	andrews	andrews	PROPN
fnp-3910	228	14	ka	ka	PROPN
fnp-3910	228	15	,	,	PUNCT
fnp-3910	228	16	stadnik	stadnik	VERB
fnp-3910	228	17	p	p	PRON
fnp-3910	228	18	,	,	PUNCT
fnp-3910	228	19	joseph	joseph	PROPN
fnp-3910	228	20	ap	ap	PROPN
fnp-3910	228	21	,	,	PUNCT
fnp-3910	228	22	knox	knox	PROPN
fnp-3910	228	23	r	r	PROPN
fnp-3910	228	24	,	,	PUNCT
fnp-3910	228	25	pittman	pittman	NOUN
fnp-3910	228	26	a	a	NOUN
fnp-3910	228	27	,	,	PUNCT
fnp-3910	228	28	clark	clark	NOUN
fnp-3910	228	29	g	g	PROPN
fnp-3910	228	30	,	,	PUNCT
fnp-3910	228	31	baird	baird	PROPN
fnp-3910	228	32	w	w	PROPN
fnp-3910	228	33	,	,	PUNCT
fnp-3910	228	34	bulstrode	bulstrode	ADJ
fnp-3910	228	35	n	n	CCONJ
fnp-3910	228	36	,	,	PUNCT
fnp-3910	228	37	glover	glover	PROPN
fnp-3910	228	38	m	m	PROPN
fnp-3910	228	39	,	,	PUNCT
fnp-3910	228	40	gordon	gordon	PROPN
fnp-3910	228	41	k	k	PROPN
fnp-3910	228	42	,	,	PUNCT
fnp-3910	228	43	hargrave	hargrave	PROPN
fnp-3910	228	44	d	d	PROPN
fnp-3910	228	45	,	,	PUNCT
fnp-3910	228	46	huson	huson	PROPN
fnp-3910	228	47	sm	sm	PROPN
fnp-3910	228	48	,	,	PUNCT
fnp-3910	228	49	jacques	jacques	PROPN
fnp-3910	228	50	ts	ts	PROPN
fnp-3910	228	51	,	,	PUNCT
fnp-3910	228	52	james	james	PROPN
fnp-3910	228	53	g	g	PROPN
fnp-3910	228	54	,	,	PUNCT
fnp-3910	228	55	kondolf	kondolf	PROPN
fnp-3910	228	56	h	h	PROPN
fnp-3910	228	57	,	,	PUNCT
fnp-3910	228	58	kangesu	kangesu	PROPN
fnp-3910	228	59	h	h	PROPN
fnp-3910	228	60	,	,	PUNCT
fnp-3910	228	61	keppler	keppler	NOUN
fnp-3910	228	62	-	-	PUNCT
fnp-3910	228	63	noreuil	noreuil	PROPN
fnp-3910	228	64	km	km	PROPN
fnp-3910	228	65	,	,	PUNCT
fnp-3910	228	66	khan	khan	PROPN
fnp-3910	228	67	a	a	PRON
fnp-3910	228	68	,	,	PUNCT
fnp-3910	228	69	lindhurst	lindhurst	PROPN
fnp-3910	228	70	mj	mj	PROPN
fnp-3910	228	71	,	,	PUNCT
fnp-3910	228	72	lipson	lipson	PROPN
fnp-3910	228	73	m	m	PROPN
fnp-3910	228	74	,	,	PUNCT
fnp-3910	228	75	mansour	mansour	PROPN
fnp-3910	228	76	a	a	PRON
fnp-3910	228	77	,	,	PUNCT
fnp-3910	228	78	o’hara	o’hara	PROPN
fnp-3910	228	79	j	j	PROPN
fnp-3910	228	80	,	,	PUNCT
fnp-3910	228	81	mahon	mahon	PROPN
fnp-3910	228	82	c	c	AUX
fnp-3910	228	83	,	,	PUNCT
fnp-3910	228	84	mosica	mosica	NOUN
fnp-3910	228	85	a	a	NOUN
fnp-3910	228	86	,	,	PUNCT
fnp-3910	228	87	moss	moss	NOUN
fnp-3910	228	88	a	a	NOUN
fnp-3910	228	89	,	,	PUNCT
fnp-3910	228	90	murthy	murthy	PROPN
fnp-3910	228	91	a	a	PRON
fnp-3910	228	92	,	,	PUNCT
fnp-3910	228	93	ong	ong	PROPN
fnp-3910	228	94	j	j	PROPN
fnp-3910	228	95	,	,	PUNCT
fnp-3910	228	96	parker	parker	PROPN
fnp-3910	228	97	ve	ve	PROPN
fnp-3910	228	98	,	,	PUNCT
fnp-3910	228	99	rivière	rivière	PROPN
fnp-3910	228	100	j	j	PROPN
fnp-3910	228	101	-	-	PROPN
fnp-3910	228	102	p	p	PROPN
fnp-3910	228	103	,	,	PUNCT
fnp-3910	228	104	sapp	sapp	PROPN
fnp-3910	228	105	jc	jc	PROPN
fnp-3910	228	106	,	,	PUNCT
fnp-3910	228	107	sebire	sebire	VERB
fnp-3910	228	108	nj	nj	PROPN
fnp-3910	228	109	,	,	PUNCT
fnp-3910	228	110	shah	shah	PROPN
fnp-3910	228	111	r	r	PROPN
fnp-3910	228	112	,	,	PUNCT
fnp-3910	228	113	sivakumar	sivakumar	PROPN
fnp-3910	228	114	b	b	PROPN
fnp-3910	228	115	,	,	PUNCT
fnp-3910	228	116	thomas	thomas	PROPN
fnp-3910	228	117	a	a	X
fnp-3910	228	118	,	,	PUNCT
fnp-3910	228	119	virasami	virasami	NOUN
fnp-3910	228	120	a	a	NOUN
fnp-3910	228	121	,	,	PUNCT
fnp-3910	228	122	waelchli	waelchli	PROPN
fnp-3910	228	123	r	r	NOUN
fnp-3910	228	124	,	,	PUNCT
fnp-3910	228	125	zeng	zeng	PROPN
fnp-3910	228	126	z	z	PROPN
fnp-3910	228	127	,	,	PUNCT
fnp-3910	228	128	biesecker	biesecker	PROPN
fnp-3910	228	129	lg	lg	PROPN
fnp-3910	228	130	,	,	PUNCT
fnp-3910	228	131	barnacle	barnacle	NOUN
fnp-3910	228	132	a	a	PRON
fnp-3910	228	133	,	,	PUNCT
fnp-3910	228	134	topf	topf	NOUN
fnp-3910	228	135	m	m	PROPN
fnp-3910	228	136	,	,	PUNCT
fnp-3910	228	137	semple	semple	PROPN
fnp-3910	228	138	rk	rk	PROPN
fnp-3910	228	139	,	,	PUNCT
fnp-3910	228	140	patton	patton	PROPN
fnp-3910	228	141	ee	ee	PROPN
fnp-3910	228	142	,	,	PUNCT
fnp-3910	228	143	kinsler	kinsler	PROPN
fnp-3910	228	144	va	va	PROPN
fnp-3910	228	145	.	.	PROPN
fnp-3910	229	1	mosaic	mosaic	PROPN
fnp-3910	229	2	ras	ras	PROPN
fnp-3910	229	3	/	/	SYM
fnp-3910	229	4	mapk	mapk	NOUN
fnp-3910	229	5	variants	variant	NOUN
fnp-3910	229	6	cause	cause	VERB
fnp-3910	229	7	sporadic	sporadic	ADJ
fnp-3910	229	8	vascular	vascular	ADJ
fnp-3910	229	9	malformations	malformation	NOUN
fnp-3910	229	10	which	which	PRON
fnp-3910	229	11	respond	respond	VERB
fnp-3910	229	12	to	to	ADP
fnp-3910	229	13	targeted	target	VERB
fnp-3910	229	14	therapy	therapy	NOUN
fnp-3910	229	15	.	.	PUNCT
fnp-3910	230	1	j	j	PROPN
fnp-3910	230	2	clin	clin	PROPN
fnp-3910	230	3	invest	invest	PROPN
fnp-3910	230	4	.	.	PUNCT
fnp-3910	231	1	2018	2018	NUM
fnp-3910	231	2	nov	nov	PROPN
fnp-3910	231	3	1;128(11):5185	1;128(11):5185	PROPN
fnp-3910	231	4	.	.	PUNCT
fnp-3910	232	1	https://doi.org/10.1172/jci124649	https://doi.org/10.1172/jci124649	NOUN
fnp-3910	232	2	park	park	NOUN
fnp-3910	232	3	es	es	NOUN
fnp-3910	232	4	,	,	PUNCT
fnp-3910	232	5	kim	kim	PROPN
fnp-3910	232	6	s	s	PROPN
fnp-3910	232	7	,	,	PUNCT
fnp-3910	232	8	huang	huang	PROPN
fnp-3910	232	9	s	s	PROPN
fnp-3910	232	10	,	,	PUNCT
fnp-3910	232	11	yoo	yoo	PROPN
fnp-3910	232	12	jy	jy	PROPN
fnp-3910	232	13	,	,	PUNCT
fnp-3910	232	14	körbelin	körbelin	PROPN
fnp-3910	232	15	j	j	PROPN
fnp-3910	232	16	,	,	PUNCT
fnp-3910	232	17	lee	lee	PROPN
fnp-3910	232	18	tj	tj	PROPN
fnp-3910	232	19	,	,	PUNCT
fnp-3910	232	20	kaur	kaur	PROPN
fnp-3910	232	21	b	b	NOUN
fnp-3910	232	22	,	,	PUNCT
fnp-3910	232	23	dash	dash	NOUN
fnp-3910	232	24	pk	pk	NOUN
fnp-3910	232	25	,	,	PUNCT
fnp-3910	232	26	chen	chen	PROPN
fnp-3910	232	27	pr	pr	PROPN
fnp-3910	232	28	,	,	PUNCT
fnp-3910	232	29	kim	kim	PROPN
fnp-3910	232	30	e.	e.	PROPN
fnp-3910	232	31	selective	selective	ADJ
fnp-3910	232	32	endothelial	endothelial	ADJ
fnp-3910	232	33	hyperactivation	hyperactivation	NOUN
fnp-3910	232	34	of	of	ADP
fnp-3910	232	35	oncogenic	oncogenic	ADJ
fnp-3910	232	36	kras	kra	NOUN
fnp-3910	232	37	induces	induce	VERB
fnp-3910	232	38	brain	brain	NOUN
fnp-3910	232	39	arteriovenous	arteriovenous	ADJ
fnp-3910	232	40	malformations	malformation	NOUN
fnp-3910	232	41	in	in	ADP
fnp-3910	232	42	mice	mouse	NOUN
fnp-3910	232	43	.	.	PUNCT
fnp-3910	233	1	ann	ann	PROPN
fnp-3910	233	2	neurol	neurol	PROPN
fnp-3910	233	3	.	.	PUNCT
fnp-3910	234	1	2021	2021	NUM
fnp-3910	234	2	may	may	PROPN
fnp-3910	234	3	89(5):926	89(5):926	PROPN
fnp-3910	234	4	-	-	PUNCT
fnp-3910	234	5	941	941	NUM
fnp-3910	234	6	.	.	PUNCT
fnp-3910	235	1	https://doi.org/10.1002/ana.26059	https://doi.org/10.1002/ana.26059	PROPN
fnp-3910	235	2	ren	ren	PROPN
fnp-3910	235	3	aa	aa	NOUN
fnp-3910	235	4	,	,	PUNCT
fnp-3910	235	5	snellings	snelling	NOUN
fnp-3910	235	6	da	da	PROPN
fnp-3910	235	7	,	,	PUNCT
fnp-3910	235	8	su	su	PROPN
fnp-3910	235	9	ys	ys	PROPN
fnp-3910	235	10	,	,	PUNCT
fnp-3910	235	11	hong	hong	PROPN
fnp-3910	235	12	cc	cc	PROPN
fnp-3910	235	13	,	,	PUNCT
fnp-3910	235	14	castro	castro	PROPN
fnp-3910	235	15	m	m	PROPN
fnp-3910	235	16	,	,	PUNCT
fnp-3910	235	17	tang	tang	X
fnp-3910	235	18	at	at	ADP
fnp-3910	235	19	,	,	PUNCT
fnp-3910	235	20	detter	detter	PROPN
fnp-3910	235	21	mr	mr	PROPN
fnp-3910	235	22	,	,	PUNCT
fnp-3910	235	23	hobson	hobson	PROPN
fnp-3910	235	24	n	n	PROPN
fnp-3910	235	25	,	,	PUNCT
fnp-3910	235	26	girard	girard	PROPN
fnp-3910	235	27	r	r	PROPN
fnp-3910	235	28	,	,	PUNCT
fnp-3910	235	29	romanos	romanos	PROPN
fnp-3910	235	30	s	s	PROPN
fnp-3910	235	31	,	,	PUNCT
fnp-3910	235	32	lightle	lightle	ADJ
fnp-3910	235	33	r	r	NOUN
fnp-3910	235	34	,	,	PUNCT
fnp-3910	235	35	moore	moore	PROPN
fnp-3910	235	36	t	t	PROPN
fnp-3910	235	37	,	,	PUNCT
fnp-3910	235	38	shenkar	shenkar	NOUN
fnp-3910	235	39	r	r	NOUN
fnp-3910	235	40	,	,	PUNCT
fnp-3910	235	41	benavides	benavides	PROPN
fnp-3910	235	42	c	c	PROPN
fnp-3910	235	43	,	,	PUNCT
fnp-3910	235	44	beaman	beaman	PROPN
fnp-3910	235	45	mm	mm	PROPN
fnp-3910	235	46	,	,	PUNCT
fnp-3910	235	47	müller	müller	PROPN
fnp-3910	235	48	-	-	PUNCT
fnp-3910	235	49	fielitz	fielitz	PROPN
fnp-3910	235	50	h	h	PROPN
fnp-3910	235	51	,	,	PUNCT
fnp-3910	235	52	chen	chen	PROPN
fnp-3910	235	53	m	m	PROPN
fnp-3910	235	54	,	,	PUNCT
fnp-3910	235	55	mericko	mericko	VERB
fnp-3910	235	56	p	p	NOUN
fnp-3910	235	57	,	,	PUNCT
fnp-3910	235	58	yang	yang	PROPN
fnp-3910	235	59	j	j	PROPN
fnp-3910	235	60	,	,	PUNCT
fnp-3910	235	61	sung	sing	VERB
fnp-3910	235	62	dc	dc	PROPN
fnp-3910	235	63	,	,	PUNCT
fnp-3910	235	64	lawton	lawton	PROPN
fnp-3910	235	65	mt	mt	PROPN
fnp-3910	235	66	,	,	PUNCT
fnp-3910	235	67	ruppert	ruppert	PROPN
fnp-3910	235	68	jm	jm	PROPN
fnp-3910	235	69	,	,	PUNCT
fnp-3910	235	70	schwaninger	schwaninger	NOUN
fnp-3910	235	71	m	m	PROPN
fnp-3910	235	72	,	,	PUNCT
fnp-3910	235	73	körbelin	körbelin	PROPN
fnp-3910	235	74	j	j	PROPN
fnp-3910	235	75	,	,	PUNCT
fnp-3910	235	76	potente	potente	PROPN
fnp-3910	235	77	m	m	PROPN
fnp-3910	235	78	,	,	PUNCT
fnp-3910	235	79	awad	awad	PROPN
fnp-3910	235	80	ia	ia	PROPN
fnp-3910	235	81	,	,	PUNCT
fnp-3910	235	82	marchuk	marchuk	PROPN
fnp-3910	235	83	da	da	PROPN
fnp-3910	235	84	,	,	PUNCT
fnp-3910	235	85	kahn	kahn	PROPN
fnp-3910	235	86	ml	ml	PROPN
fnp-3910	235	87	.	.	PUNCT
fnp-3910	236	1	pik3ca	pik3ca	NOUN
fnp-3910	236	2	and	and	CCONJ
fnp-3910	236	3	ccm	ccm	NOUN
fnp-3910	236	4	mutations	mutation	NOUN
fnp-3910	236	5	fuel	fuel	NOUN
fnp-3910	236	6	cavernomas	cavernoma	NOUN
fnp-3910	236	7	through	through	ADP
fnp-3910	236	8	a	a	DET
fnp-3910	236	9	cancer	cancer	NOUN
fnp-3910	236	10	-	-	PUNCT
fnp-3910	236	11	like	like	ADJ
fnp-3910	236	12	mechanism	mechanism	NOUN
fnp-3910	236	13	.	.	PUNCT
fnp-3910	237	1	nature	nature	NOUN
fnp-3910	237	2	.	.	PUNCT
fnp-3910	238	1	2021	2021	NUM
fnp-3910	238	2	jun	jun	PROPN
fnp-3910	238	3	594(7862):271	594(7862):271	PROPN
fnp-3910	238	4	-	-	SYM
fnp-3910	238	5	276	276	NUM
fnp-3910	238	6	.	.	PUNCT
fnp-3910	239	1	https://doi.org/10.1038/s41586-021-03562-8	https://doi.org/10.1038/s41586-021-03562-8	PROPN
fnp-3910	239	2	shi	shi	PROPN
fnp-3910	239	3	l	l	PROPN
fnp-3910	239	4	,	,	PUNCT
fnp-3910	239	5	sun	sun	PROPN
fnp-3910	239	6	z	z	PROPN
fnp-3910	239	7	,	,	PUNCT
fnp-3910	239	8	su	su	PROPN
fnp-3910	239	9	w	w	PROPN
fnp-3910	239	10	,	,	PUNCT
fnp-3910	239	11	xu	xu	PROPN
fnp-3910	240	1	f	f	PROPN
fnp-3910	240	2	,	,	PUNCT
fnp-3910	240	3	xie	xie	PROPN
fnp-3910	241	1	d	d	PROPN
fnp-3910	241	2	,	,	PUNCT
fnp-3910	241	3	zhang	zhang	PROPN
fnp-3910	241	4	q	q	PROPN
fnp-3910	241	5	,	,	PUNCT
fnp-3910	241	6	dai	dai	PROPN
fnp-3910	241	7	x	x	PROPN
fnp-3910	241	8	,	,	PUNCT
fnp-3910	241	9	iyer	iyer	PROPN
fnp-3910	241	10	k	k	PROPN
fnp-3910	241	11	,	,	PUNCT
fnp-3910	241	12	hitchens	hitchens	PROPN
fnp-3910	241	13	tk	tk	PROPN
fnp-3910	241	14	,	,	PUNCT
fnp-3910	241	15	foley	foley	PROPN
fnp-3910	241	16	lm	lm	PROPN
fnp-3910	241	17	,	,	PUNCT
fnp-3910	241	18	li	li	PROPN
fnp-3910	241	19	s	s	PROPN
fnp-3910	241	20	,	,	PUNCT
fnp-3910	241	21	stolz	stolz	PROPN
fnp-3910	241	22	db	db	PROPN
fnp-3910	241	23	,	,	PUNCT
fnp-3910	241	24	chen	chen	PROPN
fnp-3910	241	25	k	k	PROPN
fnp-3910	241	26	,	,	PUNCT
fnp-3910	241	27	ding	de	VERB
fnp-3910	241	28	y	y	PROPN
fnp-3910	241	29	,	,	PUNCT
fnp-3910	241	30	thomson	thomson	PROPN
fnp-3910	241	31	aw	aw	INTJ
fnp-3910	241	32	,	,	PUNCT
fnp-3910	241	33	leak	leak	VERB
fnp-3910	241	34	rk	rk	PRON
fnp-3910	241	35	,	,	PUNCT
fnp-3910	241	36	chen	chen	PROPN
fnp-3910	241	37	j	j	PROPN
fnp-3910	241	38	,	,	PUNCT
fnp-3910	241	39	hu	hu	PROPN
fnp-3910	241	40	x.	x.	PROPN
fnp-3910	241	41	treg	treg	PROPN
fnp-3910	241	42	cell	cell	NOUN
fnp-3910	241	43	-	-	PUNCT
fnp-3910	241	44	derived	derive	VERB
fnp-3910	241	45	osteopontin	osteopontin	NOUN
fnp-3910	241	46	promotes	promote	VERB
fnp-3910	241	47	microglia	microglia	ADJ
fnp-3910	241	48	-	-	PUNCT
fnp-3910	241	49	mediated	mediate	VERB
fnp-3910	241	50	white	white	ADJ
fnp-3910	241	51	matter	matter	NOUN
fnp-3910	241	52	repair	repair	NOUN
fnp-3910	241	53	after	after	ADP
fnp-3910	241	54	ischemic	ischemic	ADJ
fnp-3910	241	55	stroke	stroke	NOUN
fnp-3910	241	56	.	.	PUNCT
fnp-3910	242	1	immunity	immunity	NOUN
fnp-3910	242	2	.	.	PUNCT
fnp-3910	243	1	2021	2021	NUM
fnp-3910	243	2	jul	jul	PROPN
fnp-3910	243	3	13;54(7):1527	13;54(7):1527	NUM
fnp-3910	243	4	-	-	SYM
fnp-3910	243	5	1542	1542	NUM
fnp-3910	243	6	.	.	PUNCT
fnp-3910	244	1	https://doi.org/10.1016/j.immuni.2021.04.022	https://doi.org/10.1016/j.immuni.2021.04.022	PROPN
fnp-3910	244	2	brioschi	brioschi	PROPN
fnp-3910	244	3	s	s	PROPN
fnp-3910	244	4	,	,	PUNCT
fnp-3910	244	5	wang	wang	PROPN
fnp-3910	244	6	wl	wl	PROPN
fnp-3910	244	7	,	,	PUNCT
fnp-3910	244	8	peng	peng	PROPN
fnp-3910	244	9	v	v	PROPN
fnp-3910	244	10	,	,	PUNCT
fnp-3910	244	11	wang	wang	PROPN
fnp-3910	244	12	m	m	PROPN
fnp-3910	244	13	,	,	PUNCT
fnp-3910	244	14	shchukina	shchukina	PROPN
fnp-3910	244	15	i	i	PROPN
fnp-3910	244	16	,	,	PUNCT
fnp-3910	244	17	greenberg	greenberg	PROPN
fnp-3910	244	18	zj	zj	PROPN
fnp-3910	244	19	,	,	PUNCT
fnp-3910	244	20	bando	bando	PROPN
fnp-3910	244	21	jk	jk	PROPN
fnp-3910	244	22	,	,	PUNCT
fnp-3910	244	23	jaeger	jaeger	PROPN
fnp-3910	244	24	n	n	CCONJ
fnp-3910	244	25	,	,	PUNCT
fnp-3910	244	26	czepielewski	czepielewski	ADJ
fnp-3910	244	27	rs	rs	PROPN
fnp-3910	244	28	,	,	PUNCT
fnp-3910	244	29	swain	swain	PROPN
fnp-3910	244	30	a	a	PRON
fnp-3910	244	31	,	,	PUNCT
fnp-3910	244	32	mogilenko	mogilenko	PROPN
fnp-3910	244	33	da	da	PROPN
fnp-3910	244	34	,	,	PUNCT
fnp-3910	244	35	beatty	beatty	PROPN
fnp-3910	244	36	wl	wl	PROPN
fnp-3910	244	37	,	,	PUNCT
fnp-3910	244	38	bayguinov	bayguinov	NOUN
fnp-3910	244	39	p	p	PROPN
fnp-3910	244	40	,	,	PUNCT
fnp-3910	244	41	fitzpatrick	fitzpatrick	PROPN
fnp-3910	244	42	jaj	jaj	PROPN
fnp-3910	244	43	,	,	PUNCT
fnp-3910	244	44	schuettpelz	schuettpelz	PROPN
fnp-3910	244	45	lg	lg	PROPN
fnp-3910	244	46	,	,	PUNCT
fnp-3910	244	47	fronick	fronick	PROPN
fnp-3910	244	48	cc	cc	PROPN
fnp-3910	244	49	,	,	PUNCT
fnp-3910	244	50	smirnov	smirnov	PROPN
fnp-3910	244	51	i	i	PROPN
fnp-3910	244	52	,	,	PUNCT
fnp-3910	244	53	kipnis	kipnis	PROPN
fnp-3910	244	54	j	j	PROPN
fnp-3910	244	55	,	,	PUNCT
fnp-3910	244	56	shapiro	shapiro	PROPN
fnp-3910	244	57	vs	vs	ADP
fnp-3910	244	58	,	,	PUNCT
fnp-3910	244	59	wu	wu	PROPN
fnp-3910	244	60	gf	gf	PROPN
fnp-3910	244	61	,	,	PUNCT
fnp-3910	244	62	gilfillan	gilfillan	PROPN
fnp-3910	244	63	s	s	PROPN
fnp-3910	244	64	,	,	PUNCT
fnp-3910	244	65	cella	cella	PROPN
fnp-3910	244	66	m	m	PROPN
fnp-3910	244	67	,	,	PUNCT
fnp-3910	244	68	artyomov	artyomov	PROPN
fnp-3910	244	69	mn	mn	PROPN
fnp-3910	244	70	,	,	PUNCT
fnp-3910	244	71	kleinstein	kleinstein	PROPN
fnp-3910	244	72	sh	sh	PROPN
fnp-3910	244	73	,	,	PUNCT
fnp-3910	244	74	colonna	colonna	NOUN
fnp-3910	244	75	m.	m.	NOUN
fnp-3910	244	76	heterogeneity	heterogeneity	NOUN
fnp-3910	244	77	of	of	ADP
fnp-3910	244	78	meningeal	meningeal	ADJ
fnp-3910	244	79	b	b	PROPN
fnp-3910	244	80	cells	cell	NOUN
fnp-3910	244	81	reveals	reveal	VERB
fnp-3910	244	82	a	a	DET
fnp-3910	244	83	lymphopoietic	lymphopoietic	ADJ
fnp-3910	244	84	niche	niche	NOUN
fnp-3910	244	85	at	at	ADP
fnp-3910	244	86	the	the	DET
fnp-3910	244	87	cns	cns	PROPN
fnp-3910	244	88	borders	border	NOUN
fnp-3910	244	89	.	.	PUNCT
fnp-3910	245	1	science	science	NOUN
fnp-3910	245	2	.	.	PUNCT
fnp-3910	246	1	2021	2021	NUM
fnp-3910	246	2	jul	jul	PROPN
fnp-3910	246	3	23;373(6553	23;373(6553	PROPN
fnp-3910	246	4	)	)	PUNCT
fnp-3910	246	5	.	.	PUNCT
fnp-3910	247	1	https://doi.org/10.1126/science.abf9277	https://doi.org/10.1126/science.abf9277	NOUN
fnp-3910	247	2	schafflick	schafflick	PROPN
fnp-3910	247	3	d	d	NOUN
fnp-3910	247	4	,	,	PUNCT
fnp-3910	247	5	wolbert	wolbert	PROPN
fnp-3910	247	6	j	j	PROPN
fnp-3910	247	7	,	,	PUNCT
fnp-3910	247	8	heming	hem	VERB
fnp-3910	247	9	m	m	PROPN
fnp-3910	247	10	,	,	PUNCT
fnp-3910	247	11	thomas	thomas	PROPN
fnp-3910	247	12	c	c	PROPN
fnp-3910	247	13	,	,	PUNCT
fnp-3910	247	14	hartlehnert	hartlehnert	PROPN
fnp-3910	247	15	m	m	PROPN
fnp-3910	247	16	,	,	PUNCT
fnp-3910	247	17	börsch	börsch	PROPN
fnp-3910	247	18	al	al	PROPN
fnp-3910	247	19	,	,	PUNCT
fnp-3910	247	20	ricci	ricci	PROPN
fnp-3910	247	21	a	a	PROPN
fnp-3910	247	22	,	,	PUNCT
fnp-3910	247	23	martín	martín	NOUN
fnp-3910	247	24	-	-	PUNCT
fnp-3910	247	25	salamanca	salamanca	PROPN
fnp-3910	247	26	s	s	PROPN
fnp-3910	247	27	,	,	PUNCT
fnp-3910	247	28	li	li	PROPN
fnp-3910	247	29	x	x	PROPN
fnp-3910	247	30	,	,	PUNCT
fnp-3910	247	31	lu	lu	VERB
fnp-3910	247	32	in	in	ADV
fnp-3910	247	33	,	,	PUNCT
fnp-3910	247	34	pawlak	pawlak	ADJ
fnp-3910	247	35	m	m	PROPN
fnp-3910	247	36	,	,	PUNCT
fnp-3910	247	37	minnerup	minnerup	PROPN
fnp-3910	247	38	j	j	PROPN
fnp-3910	247	39	,	,	PUNCT
fnp-3910	247	40	strecker	strecker	PROPN
fnp-3910	247	41	jk	jk	PROPN
fnp-3910	247	42	,	,	PUNCT
fnp-3910	247	43	seidenbecher	seidenbecher	NOUN
fnp-3910	247	44	t	t	PROPN
fnp-3910	247	45	,	,	PUNCT
fnp-3910	247	46	meuth	meuth	PROPN
fnp-3910	247	47	sg	sg	PROPN
fnp-3910	247	48	,	,	PUNCT
fnp-3910	247	49	hidalgo	hidalgo	PROPN
fnp-3910	247	50	a	a	PROPN
fnp-3910	247	51	,	,	PUNCT
fnp-3910	247	52	liesz	liesz	PROPN
fnp-3910	247	53	a	a	NOUN
fnp-3910	247	54	,	,	PUNCT
fnp-3910	247	55	wiendl	wiendl	PROPN
fnp-3910	247	56	h	h	PROPN
fnp-3910	247	57	,	,	PUNCT
fnp-3910	247	58	meyer	meyer	PROPN
fnp-3910	247	59	zu	zu	PROPN
fnp-3910	247	60	horste	horste	PROPN
fnp-3910	247	61	g.	g.	PROPN
fnp-3910	247	62	single	single	ADJ
fnp-3910	247	63	-	-	PUNCT
fnp-3910	247	64	cell	cell	NOUN
fnp-3910	247	65	profiling	profiling	NOUN
fnp-3910	247	66	of	of	ADP
fnp-3910	247	67	cns	cns	PROPN
fnp-3910	247	68	border	border	NOUN
fnp-3910	247	69	compartment	compartment	NOUN
fnp-3910	247	70	leukocytes	leukocyte	NOUN
fnp-3910	247	71	reveals	reveal	VERB
fnp-3910	247	72	that	that	SCONJ
fnp-3910	247	73	b	b	NOUN
fnp-3910	247	74	cells	cell	NOUN
fnp-3910	247	75	and	and	CCONJ
fnp-3910	247	76	their	their	PRON
fnp-3910	247	77	progenitors	progenitor	NOUN
fnp-3910	247	78	reside	reside	VERB
fnp-3910	247	79	in	in	ADP
fnp-3910	247	80	non	non	ADJ
fnp-3910	247	81	-	-	ADJ
fnp-3910	247	82	diseased	diseased	ADJ
fnp-3910	247	83	meninges	meninge	NOUN
fnp-3910	247	84	.	.	PUNCT
fnp-3910	248	1	nat	nat	PROPN
fnp-3910	248	2	neurosci	neurosci	PROPN
fnp-3910	248	3	.	.	PUNCT
fnp-3910	249	1	2021	2021	NUM
fnp-3910	249	2	sep	sep	PROPN
fnp-3910	249	3	24(9):1225	24(9):1225	NUM
fnp-3910	249	4	-	-	SYM
fnp-3910	249	5	1234	1234	NUM
fnp-3910	249	6	.	.	PUNCT
fnp-3910	250	1	https://doi.org/10.1038/s41593-021-00880-y	https://doi.org/10.1038/s41593-021-00880-y	NOUN
fnp-3910	250	2	cugurra	cugurra	VERB
fnp-3910	250	3	a	a	PRON
fnp-3910	250	4	,	,	PUNCT
fnp-3910	250	5	mamuladze	mamuladze	PROPN
fnp-3910	250	6	t	t	PROPN
fnp-3910	250	7	,	,	PUNCT
fnp-3910	250	8	rustenhoven	rustenhoven	PROPN
fnp-3910	250	9	j	j	PROPN
fnp-3910	250	10	,	,	PUNCT
fnp-3910	250	11	dykstra	dykstra	PROPN
fnp-3910	250	12	t	t	PROPN
fnp-3910	250	13	,	,	PUNCT
fnp-3910	250	14	beroshvili	beroshvili	NOUN
fnp-3910	250	15	g	g	PROPN
fnp-3910	250	16	,	,	PUNCT
fnp-3910	250	17	greenberg	greenberg	PROPN
fnp-3910	250	18	zj	zj	PROPN
fnp-3910	250	19	,	,	PUNCT
fnp-3910	250	20	baker	baker	PROPN
fnp-3910	250	21	w	w	PROPN
fnp-3910	250	22	,	,	PUNCT
fnp-3910	250	23	papadopoulos	papadopoulos	PROPN
fnp-3910	250	24	z	z	PROPN
fnp-3910	250	25	,	,	PUNCT
fnp-3910	250	26	drieu	drieu	PROPN
fnp-3910	250	27	a	a	PRON
fnp-3910	250	28	,	,	PUNCT
fnp-3910	250	29	blackburn	blackburn	PROPN
fnp-3910	250	30	s	s	PROPN
fnp-3910	250	31	,	,	PUNCT
fnp-3910	250	32	kanamori	kanamori	PROPN
fnp-3910	250	33	m	m	PROPN
fnp-3910	250	34	,	,	PUNCT
fnp-3910	250	35	brioschi	brioschi	PROPN
fnp-3910	250	36	s	s	PROPN
fnp-3910	250	37	,	,	PUNCT
fnp-3910	250	38	herz	herz	PROPN
fnp-3910	250	39	j	j	PROPN
fnp-3910	250	40	,	,	PUNCT
fnp-3910	250	41	schuettpelz	schuettpelz	PROPN
fnp-3910	250	42	lg	lg	NOUN
fnp-3910	250	43	,	,	PUNCT
fnp-3910	250	44	colonna	colonna	NOUN
fnp-3910	250	45	m	m	PROPN
fnp-3910	250	46	,	,	PUNCT
fnp-3910	250	47	smirnov	smirnov	PROPN
fnp-3910	250	48	i	i	PROPN
fnp-3910	250	49	,	,	PUNCT
fnp-3910	250	50	kipnis	kipnis	PROPN
fnp-3910	250	51	j.	j.	PROPN
fnp-3910	250	52	skull	skull	PROPN
fnp-3910	250	53	and	and	CCONJ
fnp-3910	250	54	vertebral	vertebral	ADJ
fnp-3910	250	55	bone	bone	NOUN
fnp-3910	250	56	marrow	marrow	NOUN
fnp-3910	250	57	are	be	AUX
fnp-3910	250	58	myeloid	myeloid	ADJ
fnp-3910	250	59	cell	cell	NOUN
fnp-3910	250	60	reservoirs	reservoir	NOUN
fnp-3910	250	61	for	for	ADP
fnp-3910	250	62	the	the	DET
fnp-3910	250	63	meninges	meninge	NOUN
fnp-3910	250	64	and	and	CCONJ
fnp-3910	250	65	cns	cns	NOUN
fnp-3910	250	66	parenchyma	parenchyma	NOUN
fnp-3910	250	67	.	.	PUNCT
fnp-3910	251	1	science	science	NOUN
fnp-3910	251	2	.	.	PUNCT
fnp-3910	252	1	2021	2021	NUM
fnp-3910	252	2	jul	jul	PROPN
fnp-3910	252	3	23;373(6553	23;373(6553	PROPN
fnp-3910	252	4	)	)	PUNCT
fnp-3910	252	5	.	.	PUNCT
fnp-3910	253	1	https://doi.org/10.1126/science.abf7844	https://doi.org/10.1126/science.abf7844	PROPN
fnp-3910	253	2	d'errico	d'errico	PROPN
fnp-3910	253	3	p	p	X
fnp-3910	253	4	,	,	PUNCT
fnp-3910	253	5	ziegler	ziegler	NOUN
fnp-3910	253	6	-	-	NOUN
fnp-3910	253	7	waldkirch	waldkirch	PROPN
fnp-3910	253	8	s	s	PROPN
fnp-3910	253	9	,	,	PUNCT
fnp-3910	253	10	aires	aires	PROPN
fnp-3910	253	11	v	v	PROPN
fnp-3910	253	12	,	,	PUNCT
fnp-3910	253	13	hoffmann	hoffmann	PROPN
fnp-3910	253	14	p	p	PROPN
fnp-3910	253	15	,	,	PUNCT
fnp-3910	253	16	mezö	mezö	NOUN
fnp-3910	253	17	c	c	NOUN
fnp-3910	253	18	,	,	PUNCT
fnp-3910	253	19	erny	erny	VERB
fnp-3910	253	20	d	d	PROPN
fnp-3910	253	21	,	,	PUNCT
fnp-3910	253	22	monasor	monasor	PROPN
fnp-3910	253	23	ls	ls	PROPN
fnp-3910	253	24	,	,	PUNCT
fnp-3910	253	25	liebscher	liebscher	NOUN
fnp-3910	253	26	s	s	PROPN
fnp-3910	253	27	,	,	PUNCT
fnp-3910	253	28	ravi	ravi	PROPN
fnp-3910	253	29	vm	vm	PROPN
fnp-3910	253	30	,	,	PUNCT
fnp-3910	253	31	joseph	joseph	PROPN
fnp-3910	253	32	k	k	PROPN
fnp-3910	253	33	,	,	PUNCT
fnp-3910	253	34	schnell	schnell	PROPN
fnp-3910	253	35	o	o	PROPN
fnp-3910	253	36	,	,	PUNCT
fnp-3910	253	37	kierdorf	kierdorf	PROPN
fnp-3910	253	38	k	k	PROPN
fnp-3910	253	39	,	,	PUNCT
fnp-3910	253	40	staszewski	staszewski	PROPN
fnp-3910	253	41	o	o	NOUN
fnp-3910	253	42	,	,	PUNCT
fnp-3910	253	43	tahirovic	tahirovic	VERB
fnp-3910	253	44	s	s	PART
fnp-3910	253	45	,	,	PUNCT
fnp-3910	253	46	prinz	prinz	PROPN
fnp-3910	253	47	m	m	PROPN
fnp-3910	253	48	,	,	PUNCT
fnp-3910	253	49	meyer	meyer	PROPN
fnp-3910	253	50	-	-	PUNCT
fnp-3910	253	51	luehmann	luehmann	PROPN
fnp-3910	253	52	m.	m.	NOUN
fnp-3910	253	53	microglia	microglia	NOUN
fnp-3910	253	54	contribute	contribute	VERB
fnp-3910	253	55	to	to	ADP
fnp-3910	253	56	the	the	DET
fnp-3910	253	57	propagation	propagation	NOUN
fnp-3910	253	58	of	of	ADP
fnp-3910	253	59	aβ	aβ	PRON
fnp-3910	253	60	into	into	ADP
fnp-3910	253	61	unaffected	unaffected	ADJ
fnp-3910	253	62	brain	brain	NOUN
fnp-3910	253	63	tissue	tissue	NOUN
fnp-3910	253	64	.	.	PUNCT
fnp-3910	254	1	nat	nat	PROPN
fnp-3910	254	2	neurosci	neurosci	PROPN
fnp-3910	254	3	.	.	PUNCT
fnp-3910	255	1	2022	2022	NUM
fnp-3910	255	2	jan	jan	PROPN
fnp-3910	255	3	25(1):20	25(1):20	PROPN
fnp-3910	255	4	-	-	PUNCT
fnp-3910	255	5	25	25	NUM
fnp-3910	255	6	.	.	PUNCT
fnp-3910	255	7	https://doi.org/10.1038/s41593-021-00951-0	https://doi.org/10.1038/s41593-021-00951-0	VERB
fnp-3910	255	8	perosa	perosa	PROPN
fnp-3910	255	9	v	v	NOUN
fnp-3910	255	10	,	,	PUNCT
fnp-3910	255	11	oltmer	oltmer	PROPN
fnp-3910	255	12	j	j	PROPN
fnp-3910	255	13	,	,	PUNCT
fnp-3910	255	14	munting	munte	VERB
fnp-3910	255	15	lp	lp	NOUN
fnp-3910	255	16	,	,	PUNCT
fnp-3910	255	17	freeze	freeze	VERB
fnp-3910	255	18	wm	wm	PROPN
fnp-3910	255	19	,	,	PUNCT
fnp-3910	255	20	auger	auger	NOUN
fnp-3910	255	21	ca	ca	PROPN
fnp-3910	255	22	,	,	PUNCT
fnp-3910	255	23	scherlek	scherlek	ADJ
fnp-3910	255	24	aa	aa	NOUN
fnp-3910	255	25	,	,	PUNCT
fnp-3910	255	26	van	van	PROPN
fnp-3910	255	27	der	der	PROPN
fnp-3910	255	28	kouwe	kouwe	PROPN
fnp-3910	255	29	aj	aj	PROPN
fnp-3910	255	30	,	,	PUNCT
fnp-3910	255	31	iglesias	iglesias	PROPN
fnp-3910	255	32	je	je	PROPN
fnp-3910	255	33	,	,	PUNCT
fnp-3910	255	34	atzeni	atzeni	ADJ
fnp-3910	255	35	a	a	DET
fnp-3910	255	36	,	,	PUNCT
fnp-3910	255	37	bacskai	bacskai	ADJ
fnp-3910	255	38	bj	bj	NOUN
fnp-3910	255	39	,	,	PUNCT
fnp-3910	255	40	viswanathan	viswanathan	PROPN
fnp-3910	255	41	a	a	PROPN
fnp-3910	255	42	,	,	PUNCT
fnp-3910	255	43	frosch	frosch	PROPN
fnp-3910	255	44	mp	mp	PROPN
fnp-3910	255	45	,	,	PUNCT
fnp-3910	255	46	greenberg	greenberg	PROPN
fnp-3910	255	47	sm	sm	PROPN
fnp-3910	255	48	,	,	PUNCT
fnp-3910	255	49	van	van	PROPN
fnp-3910	255	50	veluw	veluw	NOUN
fnp-3910	255	51	sj	sj	PROPN
fnp-3910	255	52	.	.	PUNCT
fnp-3910	256	1	perivascular	perivascular	ADJ
fnp-3910	256	2	space	space	NOUN
fnp-3910	256	3	dilation	dilation	NOUN
fnp-3910	256	4	is	be	AUX
fnp-3910	256	5	associated	associate	VERB
fnp-3910	256	6	with	with	ADP
fnp-3910	256	7	vascular	vascular	ADJ
fnp-3910	256	8	amyloid	amyloid	NOUN
fnp-3910	256	9	-	-	PUNCT
fnp-3910	256	10	β	β	NOUN
fnp-3910	256	11	accumulation	accumulation	NOUN
fnp-3910	256	12	in	in	ADP
fnp-3910	256	13	the	the	DET
fnp-3910	256	14	overlying	overlying	ADJ
fnp-3910	256	15	cortex	cortex	NOUN
fnp-3910	256	16	.	.	PUNCT
fnp-3910	257	1	acta	acta	PROPN
fnp-3910	257	2	neuropathol	neuropathol	PROPN
fnp-3910	257	3	.	.	PUNCT
fnp-3910	258	1	2022	2022	NUM
fnp-3910	258	2	mar	mar	PROPN
fnp-3910	258	3	143(3):331	143(3):331	NUM
fnp-3910	258	4	-	-	SYM
fnp-3910	258	5	348	348	NUM
fnp-3910	258	6	.	.	PUNCT
fnp-3910	259	1	https://doi.org/10.1007/s00401-021-02393-1	https://doi.org/10.1007/s00401-021-02393-1	PROPN
fnp-3910	260	1	mojiri	mojiri	ADV
fnp-3910	260	2	a	a	PRON
fnp-3910	260	3	,	,	PUNCT
fnp-3910	260	4	walther	walther	NOUN
fnp-3910	260	5	bk	bk	PROPN
fnp-3910	260	6	,	,	PUNCT
fnp-3910	260	7	jiang	jiang	PROPN
fnp-3910	260	8	c	c	PROPN
fnp-3910	260	9	,	,	PUNCT
fnp-3910	260	10	matrone	matrone	ADJ
fnp-3910	260	11	g	g	PROPN
fnp-3910	260	12	,	,	PUNCT
fnp-3910	260	13	holgate	holgate	PROPN
fnp-3910	260	14	r	r	PROPN
fnp-3910	260	15	,	,	PUNCT
fnp-3910	260	16	xu	xu	PROPN
fnp-3910	261	1	q	q	PROPN
fnp-3910	261	2	,	,	PUNCT
fnp-3910	261	3	morales	morales	PROPN
fnp-3910	261	4	e	e	PROPN
fnp-3910	261	5	,	,	PUNCT
fnp-3910	261	6	wang	wang	PROPN
fnp-3910	261	7	g	g	PROPN
fnp-3910	261	8	,	,	PUNCT
fnp-3910	261	9	gu	gu	PROPN
fnp-3910	261	10	j	j	PROPN
fnp-3910	261	11	,	,	PUNCT
fnp-3910	261	12	wang	wang	PROPN
fnp-3910	261	13	r	r	PROPN
fnp-3910	261	14	,	,	PUNCT
fnp-3910	261	15	cooke	cooke	PROPN
fnp-3910	261	16	jp	jp	PROPN
fnp-3910	261	17	.	.	PUNCT
fnp-3910	262	1	telomerase	telomerase	NOUN
fnp-3910	262	2	therapy	therapy	NOUN
fnp-3910	262	3	reverses	reverse	VERB
fnp-3910	262	4	vascular	vascular	ADJ
fnp-3910	262	5	senescence	senescence	NOUN
fnp-3910	262	6	and	and	CCONJ
fnp-3910	262	7	extends	extend	VERB
fnp-3910	262	8	lifespan	lifespan	NOUN
fnp-3910	262	9	in	in	ADP
fnp-3910	262	10	progeria	progeria	NOUN
fnp-3910	262	11	mice	mouse	NOUN
fnp-3910	262	12	.	.	PUNCT
fnp-3910	263	1	eur	eur	PROPN
fnp-3910	263	2	heart	heart	NOUN
fnp-3910	263	3	j.	j.	PROPN
fnp-3910	263	4	2021	2021	NUM
fnp-3910	263	5	nov	nov	NOUN
fnp-3910	263	6	7;42(42):4352	7;42(42):4352	NUM
fnp-3910	263	7	-	-	SYM
fnp-3910	263	8	4369	4369	NUM
fnp-3910	263	9	.	.	PUNCT
fnp-3910	264	1	https://doi.org/10.1093/eurheartj/ehab547	https://doi.org/10.1093/eurheartj/ehab547	PROPN
fnp-3910	264	2	hartmann	hartmann	PROPN
fnp-3910	264	3	da	da	PROPN
fnp-3910	264	4	,	,	PUNCT
fnp-3910	264	5	berthiaume	berthiaume	NOUN
fnp-3910	264	6	aa	aa	NOUN
fnp-3910	264	7	,	,	PUNCT
fnp-3910	264	8	grant	grant	PROPN
fnp-3910	264	9	ri	ri	PROPN
fnp-3910	264	10	,	,	PUNCT
fnp-3910	264	11	harrill	harrill	NOUN
fnp-3910	264	12	sa	sa	PROPN
fnp-3910	264	13	,	,	PUNCT
fnp-3910	264	14	koski	koski	PROPN
fnp-3910	264	15	t	t	PROPN
fnp-3910	264	16	,	,	PUNCT
fnp-3910	264	17	tieu	tieu	PROPN
fnp-3910	264	18	t	t	PROPN
fnp-3910	264	19	,	,	PUNCT
fnp-3910	264	20	mcdowell	mcdowell	PROPN
fnp-3910	264	21	kp	kp	PROPN
fnp-3910	264	22	,	,	PUNCT
fnp-3910	264	23	faino	faino	PROPN
fnp-3910	264	24	av	av	PROPN
fnp-3910	264	25	,	,	PUNCT
fnp-3910	264	26	kelly	kelly	PROPN
fnp-3910	264	27	al	al	PROPN
fnp-3910	264	28	,	,	PUNCT
fnp-3910	264	29	shih	shih	PROPN
fnp-3910	264	30	ay	ay	PROPN
fnp-3910	264	31	.	.	PUNCT
fnp-3910	265	1	brain	brain	NOUN
fnp-3910	265	2	capillary	capillary	ADJ
fnp-3910	265	3	pericytes	pericyte	NOUN
fnp-3910	265	4	exert	exert	VERB
fnp-3910	265	5	a	a	DET
fnp-3910	265	6	substantial	substantial	ADJ
fnp-3910	265	7	but	but	CCONJ
fnp-3910	265	8	slow	slow	ADJ
fnp-3910	265	9	influence	influence	NOUN
fnp-3910	265	10	on	on	ADP
fnp-3910	265	11	blood	blood	NOUN
fnp-3910	265	12	flow	flow	NOUN
fnp-3910	265	13	.	.	PUNCT
fnp-3910	266	1	nat	nat	PROPN
fnp-3910	266	2	neurosci	neurosci	PROPN
fnp-3910	266	3	.	.	PUNCT
fnp-3910	267	1	2021	2021	NUM
fnp-3910	267	2	may	may	AUX
fnp-3910	267	3	24(5):633	24(5):633	X
fnp-3910	267	4	-	-	PUNCT
fnp-3910	267	5	645	645	NUM
fnp-3910	267	6	.	.	PUNCT
fnp-3910	267	7	https://doi.org/10.1038/s41593-020-00793-2	https://doi.org/10.1038/s41593-020-00793-2	NUM
fnp-3910	267	8	honarpisheh	honarpisheh	VERB
fnp-3910	267	9	p	p	PROPN
fnp-3910	267	10	,	,	PUNCT
fnp-3910	267	11	bryan	bryan	PROPN
fnp-3910	267	12	rm	rm	PROPN
fnp-3910	267	13	,	,	PUNCT
fnp-3910	267	14	mccullough	mccullough	PROPN
fnp-3910	267	15	ld	ld	PROPN
fnp-3910	267	16	.	.	PUNCT
fnp-3910	268	1	aging	age	VERB
fnp-3910	268	2	microbiota	microbiota	NOUN
fnp-3910	268	3	-	-	PUNCT
fnp-3910	268	4	gut	gut	NOUN
fnp-3910	268	5	-	-	PUNCT
fnp-3910	268	6	brain	brain	NOUN
fnp-3910	268	7	axis	axis	NOUN
fnp-3910	268	8	in	in	ADP
fnp-3910	268	9	stroke	stroke	NOUN
fnp-3910	268	10	risk	risk	NOUN
fnp-3910	268	11	and	and	CCONJ
fnp-3910	268	12	outcome	outcome	NOUN
fnp-3910	268	13	.	.	PUNCT
fnp-3910	269	1	circ	circ	PROPN
fnp-3910	269	2	res	re	NOUN
fnp-3910	269	3	.	.	PUNCT
fnp-3910	270	1	2022	2022	NUM
fnp-3910	270	2	apr	apr	VERB
fnp-3910	270	3	15;130(8):1112	15;130(8):1112	NUM
fnp-3910	270	4	-	-	SYM
fnp-3910	270	5	1144	1144	NUM
fnp-3910	270	6	.	.	PUNCT
fnp-3910	271	1	https://doi.org/10.1161/circresaha.122.319983	https://doi.org/10.1161/circresaha.122.319983	ADJ
fnp-3910	271	2	copyright	copyright	NOUN
fnp-3910	271	3	:	:	PUNCT
fnp-3910	271	4	©	©	PROPN
fnp-3910	271	5	2022	2022	NUM
fnp-3910	271	6	the	the	DET
fnp-3910	271	7	author(s	author(s	NOUN
fnp-3910	271	8	)	)	PUNCT
fnp-3910	271	9	.	.	PUNCT
fnp-3910	272	1	this	this	PRON
fnp-3910	272	2	is	be	AUX
fnp-3910	272	3	an	an	DET
fnp-3910	272	4	open	open	ADJ
fnp-3910	272	5	access	access	NOUN
fnp-3910	272	6	article	article	NOUN
fnp-3910	272	7	distributed	distribute	VERB
fnp-3910	272	8	under	under	ADP
fnp-3910	272	9	the	the	DET
fnp-3910	272	10	terms	term	NOUN
fnp-3910	272	11	of	of	ADP
fnp-3910	272	12	the	the	DET
fnp-3910	272	13	creative	creative	ADJ
fnp-3910	272	14	commons	common	NOUN
fnp-3910	272	15	attribution	attribution	NOUN
fnp-3910	272	16	4.0	4.0	NUM
fnp-3910	272	17	international	international	ADJ
fnp-3910	272	18	license	license	NOUN
fnp-3910	272	19	(	(	PUNCT
fnp-3910	272	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-3910	272	21	)	)	PUNCT
fnp-3910	272	22	,	,	PUNCT
fnp-3910	272	23	which	which	PRON
fnp-3910	272	24	permits	permit	VERB
fnp-3910	272	25	unrestricted	unrestricted	ADJ
fnp-3910	272	26	use	use	NOUN
fnp-3910	272	27	,	,	PUNCT
fnp-3910	272	28	distribution	distribution	NOUN
fnp-3910	272	29	,	,	PUNCT
fnp-3910	272	30	and	and	CCONJ
fnp-3910	272	31	reproduction	reproduction	NOUN
fnp-3910	272	32	in	in	ADP
fnp-3910	272	33	any	any	DET
fnp-3910	272	34	medium	medium	NOUN
fnp-3910	272	35	,	,	PUNCT
fnp-3910	272	36	provided	provide	VERB
fnp-3910	272	37	the	the	DET
fnp-3910	272	38	original	original	ADJ
fnp-3910	272	39	author	author	NOUN
fnp-3910	272	40	and	and	CCONJ
fnp-3910	272	41	source	source	NOUN
fnp-3910	272	42	are	be	AUX
fnp-3910	272	43	credited	credit	VERB
fnp-3910	272	44	,	,	PUNCT
fnp-3910	272	45	a	a	DET
fnp-3910	272	46	link	link	NOUN
fnp-3910	272	47	to	to	ADP
fnp-3910	272	48	the	the	DET
fnp-3910	272	49	creative	creative	ADJ
fnp-3910	272	50	commons	common	NOUN
fnp-3910	272	51	license	license	NOUN
fnp-3910	272	52	is	be	AUX
fnp-3910	272	53	provided	provide	VERB
fnp-3910	272	54	,	,	PUNCT
fnp-3910	272	55	and	and	CCONJ
fnp-3910	272	56	any	any	DET
fnp-3910	272	57	changes	change	NOUN
fnp-3910	272	58	are	be	AUX
fnp-3910	272	59	indicated	indicate	VERB
fnp-3910	272	60	.	.	PUNCT
fnp-3910	273	1	the	the	DET
fnp-3910	273	2	creative	creative	ADJ
fnp-3910	273	3	commons	common	NOUN
fnp-3910	273	4	public	public	ADJ
fnp-3910	273	5	domain	domain	NOUN
fnp-3910	273	6	dedication	dedication	NOUN
fnp-3910	273	7	waiver	waiver	NOUN
fnp-3910	273	8	(	(	PUNCT
fnp-3910	273	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-3910	273	10	)	)	PUNCT
fnp-3910	273	11	applies	apply	VERB
fnp-3910	273	12	to	to	ADP
fnp-3910	273	13	the	the	DET
fnp-3910	273	14	data	datum	NOUN
fnp-3910	273	15	made	make	VERB
fnp-3910	273	16	available	available	ADJ
fnp-3910	273	17	in	in	ADP
fnp-3910	273	18	this	this	DET
fnp-3910	273	19	article	article	NOUN
fnp-3910	273	20	,	,	PUNCT
fnp-3910	273	21	unless	unless	SCONJ
fnp-3910	273	22	otherwise	otherwise	ADV
fnp-3910	273	23	stated	state	VERB
fnp-3910	273	24	.	.	PUNCT