id	sid	tid	token	lemma	pos
fnp-4366	1	1	66th	66th	ADJ
fnp-4366	1	2	annual	annual	ADJ
fnp-4366	1	3	meeting	meeting	NOUN
fnp-4366	1	4	of	of	ADP
fnp-4366	1	5	the	the	DET
fnp-4366	1	6	german	german	ADJ
fnp-4366	1	7	society	society	NOUN
fnp-4366	1	8	of	of	ADP
fnp-4366	1	9	neuropathology	neuropathology	NOUN
fnp-4366	1	10	and	and	CCONJ
fnp-4366	1	11	neuroanatomy	neuroanatomy	NOUN
fnp-4366	1	12	(	(	PUNCT
fnp-4366	1	13	dgnn	dgnn	NOUN
fnp-4366	1	14	)	)	PUNCT
fnp-4366	1	15	meeting	meeting	NOUN
fnp-4366	1	16	abstracts	abstract	NOUN
fnp-4366	1	17	feel	feel	VERB
fnp-4366	1	18	free	free	ADJ
fnp-4366	1	19	to	to	PART
fnp-4366	1	20	add	add	VERB
fnp-4366	1	21	comments	comment	NOUN
fnp-4366	1	22	by	by	ADP
fnp-4366	1	23	clicking	click	VERB
fnp-4366	1	24	these	these	DET
fnp-4366	1	25	icons	icon	NOUN
fnp-4366	1	26	on	on	ADP
fnp-4366	1	27	the	the	DET
fnp-4366	1	28	sidebar	sidebar	NOUN
fnp-4366	1	29	free	free	ADJ
fnp-4366	1	30	neuropathology	neuropathology	NOUN
fnp-4366	1	31	3:20	3:20	NUM
fnp-4366	1	32	(	(	PUNCT
fnp-4366	1	33	2022	2022	NUM
fnp-4366	1	34	)	)	PUNCT
fnp-4366	1	35	meeting	meeting	NOUN
fnp-4366	1	36	abstracts	abstract	NOUN
fnp-4366	1	37	66th	66th	ADJ
fnp-4366	1	38	annual	annual	ADJ
fnp-4366	1	39	meeting	meeting	NOUN
fnp-4366	1	40	of	of	ADP
fnp-4366	1	41	the	the	DET
fnp-4366	1	42	german	german	ADJ
fnp-4366	1	43	society	society	NOUN
fnp-4366	1	44	of	of	ADP
fnp-4366	1	45	neuropathology	neuropathology	NOUN
fnp-4366	1	46	and	and	CCONJ
fnp-4366	1	47	neuroanatomy	neuroanatomy	NOUN
fnp-4366	1	48	(	(	PUNCT
fnp-4366	1	49	dgnn	dgnn	NOUN
fnp-4366	1	50	)	)	PUNCT
fnp-4366	1	51	meeting	meeting	NOUN
fnp-4366	1	52	abstracts	abstract	VERB
fnp-4366	1	53	berlin	berlin	PROPN
fnp-4366	1	54	,	,	PUNCT
fnp-4366	1	55	november	november	PROPN
fnp-4366	1	56	1–5	1–5	NUM
fnp-4366	1	57	,	,	PUNCT
fnp-4366	1	58	2022	2022	NUM
fnp-4366	1	59	submitted	submit	VERB
fnp-4366	1	60	:	:	PUNCT
fnp-4366	1	61	09	09	NUM
fnp-4366	1	62	august	august	PROPN
fnp-4366	1	63	2022	2022	NUM
fnp-4366	1	64	accepted	accept	VERB
fnp-4366	1	65	:	:	PUNCT
fnp-4366	1	66	10	10	NUM
fnp-4366	1	67	august	august	PROPN
fnp-4366	1	68	2022	2022	NUM
fnp-4366	1	69	published	publish	VERB
fnp-4366	1	70	:	:	PUNCT
fnp-4366	1	71	10	10	NUM
fnp-4366	1	72	august	august	PROPN
fnp-4366	1	73	2022	2022	NUM
fnp-4366	1	74	  	  	SPACE
fnp-4366	1	75	liebe	liebe	NOUN
fnp-4366	1	76	kolleginnen	kolleginnen	PROPN
fnp-4366	1	77	und	und	PROPN
fnp-4366	1	78	kollegen	kollegen	PROPN
fnp-4366	1	79	,	,	PUNCT
fnp-4366	1	80	zur	zur	PROPN
fnp-4366	1	81	66	66	NUM
fnp-4366	1	82	.	.	PUNCT
fnp-4366	2	1	jahrestagung	jahrestagung	PROPN
fnp-4366	2	2	der	der	PROPN
fnp-4366	2	3	deutschen	deutschen	PROPN
fnp-4366	2	4	gesellschaft	gesellschaft	PROPN
fnp-4366	2	5	für	für	PROPN
fnp-4366	2	6	neuropathologie	neuropathologie	X
fnp-4366	2	7	und	und	PROPN
fnp-4366	2	8	neuroanatomie	neuroanatomie	ADV
fnp-4366	3	1	i	i	PRON
fnp-4366	3	2	m	m	VERB
fnp-4366	3	3	rahmen	rahmen	PROPN
fnp-4366	3	4	der	der	NOUN
fnp-4366	3	5	neurowoche	neurowoche	NOUN
fnp-4366	3	6	vom	vom	VERB
fnp-4366	3	7	1	1	NUM
fnp-4366	3	8	.	.	PUNCT
fnp-4366	3	9	bis	bis	PROPN
fnp-4366	3	10	zum	zum	PROPN
fnp-4366	3	11	5	5	NUM
fnp-4366	3	12	.	.	PUNCT
fnp-4366	3	13	november	november	PROPN
fnp-4366	3	14	2022	2022	NUM
fnp-4366	3	15	begrüße	begrüße	PROPN
fnp-4366	3	16	ich	ich	PROPN
fnp-4366	3	17	sie	sie	PROPN
fnp-4366	3	18	herzlich	herzlich	PROPN
fnp-4366	3	19	in	in	ADP
fnp-4366	3	20	berlin	berlin	PROPN
fnp-4366	3	21	.	.	PUNCT
fnp-4366	4	1	die	die	VERB
fnp-4366	4	2	letzten	letzten	PROPN
fnp-4366	4	3	jahre	jahre	PROPN
fnp-4366	4	4	haben	haben	PROPN
fnp-4366	4	5	eine	eine	PROPN
fnp-4366	4	6	enorme	enorme	PROPN
fnp-4366	4	7	erweiterung	erweiterung	PROPN
fnp-4366	4	8	der	der	PROPN
fnp-4366	4	9	analytischen	analytischen	PROPN
fnp-4366	4	10	methodik	methodik	PROPN
fnp-4366	4	11	mit	mit	PROPN
fnp-4366	4	12	schwerpunkt	schwerpunkt	PROPN
fnp-4366	4	13	auf	auf	PROPN
fnp-4366	4	14	molekularen	molekularen	PROPN
fnp-4366	4	15	untersuchungen	untersuchungen	PROPN
fnp-4366	4	16	gebracht	gebracht	PROPN
fnp-4366	4	17	.	.	PUNCT
fnp-4366	5	1	ein	ein	PROPN
fnp-4366	5	2	großer	großer	PROPN
fnp-4366	5	3	teil	teil	PROPN
fnp-4366	5	4	dieser	dieser	PROPN
fnp-4366	5	5	untersuchungen	untersuchungen	PROPN
fnp-4366	5	6	wurde	wurde	PROPN
fnp-4366	5	7	in	in	ADP
fnp-4366	5	8	unseren	unseren	PROPN
fnp-4366	5	9	einrichtungen	einrichtungen	PROPN
fnp-4366	5	10	entwickelt	entwickelt	PROPN
fnp-4366	5	11	und	und	PROPN
fnp-4366	5	12	wird	wird	NOUN
fnp-4366	5	13	dort	dort	PROPN
fnp-4366	5	14	erbracht	erbracht	PROPN
fnp-4366	5	15	.	.	PUNCT
fnp-4366	6	1	in	in	ADP
fnp-4366	6	2	der	der	ADJ
fnp-4366	6	3	tat	tat	NOUN
fnp-4366	6	4	hat	hat	NOUN
fnp-4366	6	5	sich	sich	INTJ
fnp-4366	6	6	die	die	VERB
fnp-4366	6	7	neuropathologie	neuropathologie	ADV
fnp-4366	6	8	zu	zu	PUNCT
fnp-4366	6	9	einem	einem	PROPN
fnp-4366	6	10	motor	motor	PROPN
fnp-4366	6	11	der	der	NOUN
fnp-4366	6	12	neuroonkologischen	neuroonkologischen	PROPN
fnp-4366	6	13	und	und	VERB
fnp-4366	6	14	neurowissenschaftlichen	neurowissenschaftlichen	ADV
fnp-4366	6	15	forschung	forschung	VERB
fnp-4366	6	16	entwickelt	entwickelt	NOUN
fnp-4366	6	17	und	und	ADJ
fnp-4366	6	18	deutschsprachige	deutschsprachige	VERB
fnp-4366	6	19	neuropathologische	neuropathologische	PROPN
fnp-4366	6	20	institutionen	institutionen	PROPN
fnp-4366	6	21	haben	haben	VERB
fnp-4366	6	22	wesentlich	wesentlich	DET
fnp-4366	6	23	dazu	dazu	NOUN
fnp-4366	6	24	beigetragen	beigetragen	PROPN
fnp-4366	6	25	.	.	PUNCT
fnp-4366	7	1	ganz	ganz	PROPN
fnp-4366	7	2	neue	neue	PROPN
fnp-4366	7	3	therapien	therapien	PROPN
fnp-4366	7	4	bauen	bauen	NOUN
fnp-4366	7	5	auf	auf	PROPN
fnp-4366	7	6	diese	diese	PROPN
fnp-4366	7	7	erkenntnisse	erkenntnisse	PROPN
fnp-4366	7	8	auf	auf	PROPN
fnp-4366	7	9	.	.	PUNCT
fnp-4366	8	1	dadurch	dadurch	NOUN
fnp-4366	8	2	sind	sind	PROPN
fnp-4366	8	3	wir	wir	PROPN
fnp-4366	8	4	für	für	PROPN
fnp-4366	8	5	die	die	VERB
fnp-4366	8	6	versorgung	versorgung	PROPN
fnp-4366	8	7	unserer	unserer	PROPN
fnp-4366	8	8	patienten	patienten	VERB
fnp-4366	8	9	wichtiger	wichtiger	PROPN
fnp-4366	8	10	denn	denn	PROPN
fnp-4366	8	11	jeher	jeher	PROPN
fnp-4366	8	12	.	.	PUNCT
fnp-4366	9	1	deswegen	deswegen	PROPN
fnp-4366	9	2	sehe	sehe	PROPN
fnp-4366	9	3	ich	ich	PROPN
fnp-4366	9	4	einen	einen	PROPN
fnp-4366	9	5	großen	großen	PROPN
fnp-4366	9	6	und	und	PROPN
fnp-4366	9	7	zunehmenden	zunehmenden	PROPN
fnp-4366	9	8	bedarf	bedarf	PROPN
fnp-4366	9	9	dem	dem	PROPN
fnp-4366	9	10	wir	wir	PROPN
fnp-4366	9	11	neuropathologen	neuropathologen	PROPN
fnp-4366	9	12	nachkommen	nachkommen	PROPN
fnp-4366	9	13	müssen	müssen	PROPN
fnp-4366	9	14	.	.	PUNCT
fnp-4366	10	1	alle	alle	PROPN
fnp-4366	10	2	schwerpunkte	schwerpunkte	PROPN
fnp-4366	10	3	unseres	unsere	NOUN
fnp-4366	10	4	faches	fache	NOUN
fnp-4366	10	5	sind	sind	PROPN
fnp-4366	10	6	hiervon	hiervon	PROPN
fnp-4366	10	7	betroffen	betroffen	NOUN
fnp-4366	10	8	,	,	PUNCT
fnp-4366	10	9	die	die	VERB
fnp-4366	10	10	gehirntumordiagnostik	gehirntumordiagnostik	PROPN
fnp-4366	10	11	,	,	PUNCT
fnp-4366	10	12	die	die	VERB
fnp-4366	10	13	neurodegenerativen	neurodegenerativen	VERB
fnp-4366	10	14	erkrankungen	erkrankungen	PROPN
fnp-4366	10	15	,	,	PUNCT
fnp-4366	10	16	entzündung	entzündung	VERB
fnp-4366	10	17	und	und	PROPN
fnp-4366	10	18	erkrankungen	erkrankungen	PROPN
fnp-4366	10	19	der	der	PROPN
fnp-4366	10	20	muskeln	muskeln	PROPN
fnp-4366	10	21	und	und	VERB
fnp-4366	10	22	der	der	PROPN
fnp-4366	10	23	nerven	nerven	PROPN
fnp-4366	10	24	.	.	PUNCT
fnp-4366	11	1	wir	wir	PROPN
fnp-4366	11	2	arbeiten	arbeiten	VERB
fnp-4366	11	3	eng	eng	PROPN
fnp-4366	11	4	mit	mit	PROPN
fnp-4366	11	5	unseren	unseren	PROPN
fnp-4366	11	6	kollegen	kollegen	PROPN
fnp-4366	11	7	aus	aus	PROPN
fnp-4366	11	8	der	der	PROPN
fnp-4366	11	9	neuroonkologie	neuroonkologie	ADV
fnp-4366	11	10	,	,	PUNCT
fnp-4366	11	11	neuropädiatrie	neuropädiatrie	NOUN
fnp-4366	11	12	,	,	PUNCT
fnp-4366	11	13	neurologie	neurologie	X
fnp-4366	11	14	neurochirurgie	neurochirurgie	PROPN
fnp-4366	11	15	und	und	VERB
fnp-4366	11	16	neuroradiologie	neuroradiologie	PROPN
fnp-4366	11	17	zusammen	zusamman	NOUN
fnp-4366	11	18	.	.	PUNCT
fnp-4366	12	1	der	der	PROPN
fnp-4366	12	2	interdisziplinäre	interdisziplinäre	VERB
fnp-4366	12	3	austausch	austausch	NOUN
fnp-4366	12	4	hat	hat	PROPN
fnp-4366	12	5	einen	einen	PROPN
fnp-4366	12	6	hohen	hohen	PROPN
fnp-4366	12	7	stellenwert	stellenwert	PROPN
fnp-4366	12	8	und	und	PROPN
fnp-4366	12	9	wir	wir	PROPN
fnp-4366	12	10	freuen	freuen	PROPN
fnp-4366	12	11	uns	un	NOUN
fnp-4366	12	12	deshalb	deshalb	NOUN
fnp-4366	12	13	besonders	besonder	NOUN
fnp-4366	12	14	,	,	PUNCT
fnp-4366	12	15	dass	dass	PROPN
fnp-4366	12	16	unsere	unsere	PROPN
fnp-4366	12	17	jahrestagung	jahrestagung	PROPN
fnp-4366	12	18	in	in	ADP
fnp-4366	12	19	diesem	diesem	PROPN
fnp-4366	12	20	jahr	jahr	PROPN
fnp-4366	12	21	wieder	wieder	NOUN
fnp-4366	12	22	i	i	PRON
fnp-4366	12	23	m	m	VERB
fnp-4366	12	24	rahmen	rahmen	PROPN
fnp-4366	12	25	der	der	PROPN
fnp-4366	12	26	neurowoche	neurowoche	PROPN
fnp-4366	12	27	stattfindet	stattfindet	PROPN
fnp-4366	12	28	,	,	PUNCT
fnp-4366	12	29	was	be	AUX
fnp-4366	12	30	die	die	NOUN
fnp-4366	12	31	kommunikation	kommunikation	PROPN
fnp-4366	12	32	und	und	PROPN
fnp-4366	12	33	den	den	PROPN
fnp-4366	12	34	wissenstransfer	wissenstransfer	NOUN
fnp-4366	12	35	über	über	NOUN
fnp-4366	12	36	die	die	VERB
fnp-4366	12	37	fächergrenzen	fächergrenzen	ADJ
fnp-4366	12	38	beflügelt	beflügelt	ADJ
fnp-4366	12	39	.	.	PUNCT
fnp-4366	13	1	dieses	diesis	NOUN
fnp-4366	13	2	jahr	jahr	PROPN
fnp-4366	13	3	wollen	wollen	PROPN
fnp-4366	13	4	wir	wir	PROPN
fnp-4366	13	5	besonders	besonder	NOUN
fnp-4366	13	6	die	die	VERB
fnp-4366	13	7	jungen	jungen	PROPN
fnp-4366	13	8	neuropathologen	neuropathologen	PROPN
fnp-4366	13	9	und	und	NOUN
fnp-4366	13	10	neuropathologinnen	neuropathologinnen	NOUN
fnp-4366	13	11	in	in	ADP
fnp-4366	13	12	den	den	PROPN
fnp-4366	13	13	vordergrund	vordergrund	PROPN
fnp-4366	13	14	stellen	stellen	PROPN
fnp-4366	13	15	.	.	PUNCT
fnp-4366	14	1	sie	sie	PROPN
fnp-4366	14	2	sollen	sollen	PROPN
fnp-4366	14	3	unser	unser	PROPN
fnp-4366	14	4	fach	fach	PROPN
fnp-4366	14	5	als	als	PROPN
fnp-4366	14	6	lebendig	lebendig	PROPN
fnp-4366	14	7	und	und	VERB
fnp-4366	14	8	besonders	besonder	NOUN
fnp-4366	14	9	zukunftsfähig	zukunftsfähig	PROPN
fnp-4366	14	10	erleben	erleben	PROPN
fnp-4366	14	11	.	.	PUNCT
fnp-4366	15	1	von	von	PROPN
fnp-4366	15	2	ihnen	ihnen	PROPN
fnp-4366	15	3	erwarten	erwarten	PROPN
fnp-4366	15	4	wir	wir	NOUN
fnp-4366	15	5	die	die	VERB
fnp-4366	15	6	dynamik	dynamik	ADJ
fnp-4366	15	7	,	,	PUNCT
fnp-4366	15	8	den	den	PROPN
fnp-4366	15	9	einsatz	einsatz	PROPN
fnp-4366	15	10	und	und	PROPN
fnp-4366	15	11	den	den	PROPN
fnp-4366	15	12	ideenreichtum	ideenreichtum	NOUN
fnp-4366	15	13	,	,	PUNCT
fnp-4366	15	14	der	der	NOUN
fnp-4366	15	15	die	die	VERB
fnp-4366	15	16	neuropathologie	neuropathologie	ADV
fnp-4366	15	17	in	in	ADP
fnp-4366	15	18	den	den	PROPN
fnp-4366	15	19	nächsten	nächsten	VERB
fnp-4366	15	20	jahren	jahren	PROPN
fnp-4366	15	21	noch	noch	PROPN
fnp-4366	15	22	weiter	weiter	PROPN
fnp-4366	15	23	zu	zu	PROPN
fnp-4366	15	24	einer	einer	PROPN
fnp-4366	15	25	zentralen	zentralen	PROPN
fnp-4366	15	26	querschnittsplattform	querschnittsplattform	NOUN
fnp-4366	15	27	für	für	NOUN
fnp-4366	15	28	die	die	VERB
fnp-4366	15	29	neurofächer	neurofächer	PROPN
fnp-4366	15	30	machen	machen	PROPN
fnp-4366	15	31	wird	wird	PROPN
fnp-4366	15	32	.	.	PUNCT
fnp-4366	16	1	wir	wir	PROPN
fnp-4366	16	2	haben	haben	PROPN
fnp-4366	16	3	einen	einen	PROPN
fnp-4366	16	4	kongressstrang	kongressstrang	PROPN
fnp-4366	16	5	mit	mit	PROPN
fnp-4366	16	6	wissenschaftlichen	wissenschaftlichen	SCONJ
fnp-4366	16	7	sitzungen	sitzungen	PROPN
fnp-4366	16	8	am	be	AUX
fnp-4366	16	9	donnerstag	donnerstag	NOUN
fnp-4366	16	10	,	,	PUNCT
fnp-4366	16	11	freitag	freitag	PROPN
fnp-4366	16	12	und	und	NOUN
fnp-4366	16	13	samstag	samstag	NOUN
fnp-4366	16	14	ausgerichtet	ausgerichtet	NOUN
fnp-4366	16	15	.	.	PUNCT
fnp-4366	17	1	sie	sie	PROPN
fnp-4366	17	2	dürfen	dürfen	PROPN
fnp-4366	17	3	vorträge	vorträge	PROPN
fnp-4366	17	4	mit	mit	PROPN
fnp-4366	17	5	jungen	jungen	PROPN
fnp-4366	17	6	neuropathologischen	neuropathologischen	ADV
fnp-4366	17	7	expertinnen	expertinnen	PROPN
fnp-4366	17	8	und	und	PROPN
fnp-4366	17	9	experten	experten	NOUN
fnp-4366	17	10	sowie	sowie	PROPN
fnp-4366	17	11	von	von	PROPN
fnp-4366	17	12	jungen	jungen	PROPN
fnp-4366	17	13	nachwuchswissenschaftlerinnen	nachwuchswissenschaftlerinnen	PROPN
fnp-4366	17	14	und	und	ADJ
fnp-4366	17	15	nachwuchswissenschaftlern	nachwuchswissenschaftlern	ADJ
fnp-4366	17	16	erwarten	erwarten	NOUN
fnp-4366	17	17	.	.	PUNCT
fnp-4366	18	1	ich	ich	PROPN
fnp-4366	18	2	freue	freue	NOUN
fnp-4366	18	3	mich	mich	PROPN
fnp-4366	18	4	auf	auf	PROPN
fnp-4366	18	5	lebhafte	lebhafte	PROPN
fnp-4366	18	6	diskussionen	diskussionen	PROPN
fnp-4366	18	7	und	und	PROPN
fnp-4366	18	8	spannende	spannende	PROPN
fnp-4366	18	9	interdisziplinäre	interdisziplinäre	PROPN
fnp-4366	18	10	debatten	debatten	PROPN
fnp-4366	18	11	!	!	PUNCT
fnp-4366	18	12	ihr	ihr	PROPN
fnp-4366	18	13	prof	prof	PROPN
fnp-4366	18	14	.	.	PUNCT
fnp-4366	19	1	dr	dr	PROPN
fnp-4366	19	2	.	.	PROPN
fnp-4366	19	3	andreas	andreas	PROPN
fnp-4366	19	4	von	von	PROPN
fnp-4366	19	5	deimling	deimle	VERB
fnp-4366	19	6	universitätsklinikum	universitätsklinikum	NOUN
fnp-4366	19	7	heidelberg	heidelberg	PROPN
fnp-4366	19	8	neuropathologie	neuropathologie	PROPN
fnp-4366	19	9	  	  	SPACE
fnp-4366	19	10	https://doi.org/10.17879/freeneuropathology-2022-4366	https://doi.org/10.17879/freeneuropathology-2022-4366	PROPN
fnp-4366	19	11	keywords	keyword	NOUN
fnp-4366	19	12	:	:	PUNCT
fnp-4366	19	13	german	german	ADJ
fnp-4366	19	14	society	society	NOUN
fnp-4366	19	15	of	of	ADP
fnp-4366	19	16	neuropathology	neuropathology	NOUN
fnp-4366	19	17	and	and	CCONJ
fnp-4366	19	18	neuroanatomy	neuroanatomy	NOUN
fnp-4366	19	19	,	,	PUNCT
fnp-4366	19	20	dgnn	dgnn	NOUN
fnp-4366	19	21	,	,	PUNCT
fnp-4366	19	22	meeting	meet	VERB
fnp-4366	19	23	abstracts	abstract	NOUN
fnp-4366	19	24	contents	content	NOUN
fnp-4366	19	25	1	1	NUM
fnp-4366	19	26	.	.	PUNCT
fnp-4366	20	1	new	new	ADJ
fnp-4366	20	2	diagnostic	diagnostic	ADJ
fnp-4366	20	3	methods	method	NOUN
fnp-4366	20	4	1.01	1.01	NUM
fnp-4366	20	5	methylthioadenosine	methylthioadenosine	ADJ
fnp-4366	20	6	phosphorylase	phosphorylase	NOUN
fnp-4366	20	7	immunostaining	immunostaine	VERB
fnp-4366	20	8	as	as	ADP
fnp-4366	20	9	a	a	DET
fnp-4366	20	10	surrogate	surrogate	ADJ
fnp-4366	20	11	marker	marker	NOUN
fnp-4366	20	12	for	for	ADP
fnp-4366	20	13	cdkn2a	cdkn2a	PROPN
fnp-4366	20	14	/	/	SYM
fnp-4366	20	15	b	b	NOUN
fnp-4366	20	16	homozygous	homozygous	ADJ
fnp-4366	20	17	deletion	deletion	NOUN
fnp-4366	20	18	in	in	ADP
fnp-4366	20	19	gliomas	glioma	NOUN
fnp-4366	20	20	1.02	1.02	NUM
fnp-4366	20	21	artificial	artificial	ADJ
fnp-4366	20	22	intelligence	intelligence	NOUN
fnp-4366	20	23	in	in	ADP
fnp-4366	20	24	morphomolecular	morphomolecular	ADJ
fnp-4366	20	25	analysis	analysis	NOUN
fnp-4366	20	26	of	of	ADP
fnp-4366	20	27	glioblastoma	glioblastoma	NOUN
fnp-4366	20	28	1.03	1.03	NUM
fnp-4366	20	29	histological	histological	ADJ
fnp-4366	20	30	and	and	CCONJ
fnp-4366	20	31	molecular	molecular	ADJ
fnp-4366	20	32	correlates	correlate	NOUN
fnp-4366	20	33	of	of	ADP
fnp-4366	20	34	tspo	tspo	NOUN
fnp-4366	20	35	labelling	labelling	NOUN
fnp-4366	20	36	in	in	ADP
fnp-4366	20	37	human	human	ADJ
fnp-4366	20	38	brain	brain	NOUN
fnp-4366	20	39	tissue	tissue	NOUN
fnp-4366	20	40	1.04	1.04	NUM
fnp-4366	20	41	towards	towards	ADP
fnp-4366	20	42	swift	swift	ADJ
fnp-4366	20	43	and	and	CCONJ
fnp-4366	20	44	accessible	accessible	ADJ
fnp-4366	20	45	precision	precision	NOUN
fnp-4366	20	46	cns	cns	NOUN
fnp-4366	20	47	tumour	tumour	NOUN
fnp-4366	20	48	diagnostics	diagnostic	NOUN
fnp-4366	20	49	using	use	VERB
fnp-4366	20	50	third	third	ADJ
fnp-4366	20	51	generation	generation	NOUN
fnp-4366	20	52	sequencing	sequence	VERB
fnp-4366	20	53	and	and	CCONJ
fnp-4366	20	54	deep	deep	ADJ
fnp-4366	20	55	transfer	transfer	NOUN
fnp-4366	20	56	learning	learn	VERB
fnp-4366	20	57	1.05	1.05	NUM
fnp-4366	20	58	retinal	retinal	ADJ
fnp-4366	20	59	pathology	pathology	NOUN
fnp-4366	20	60	as	as	ADP
fnp-4366	20	61	potential	potential	ADJ
fnp-4366	20	62	biomarker	biomarker	NOUN
fnp-4366	20	63	of	of	ADP
fnp-4366	20	64	symptom	symptom	NOUN
fnp-4366	20	65	severity	severity	NOUN
fnp-4366	20	66	and	and	CCONJ
fnp-4366	20	67	impairment	impairment	NOUN
fnp-4366	20	68	in	in	ADP
fnp-4366	20	69	patients	patient	NOUN
fnp-4366	20	70	with	with	ADP
fnp-4366	20	71	stiff	stiff	ADJ
fnp-4366	20	72	person	person	NOUN
fnp-4366	20	73	syndrome	syndrome	NOUN
fnp-4366	20	74	1.06	1.06	NUM
fnp-4366	20	75	deep	deep	ADJ
fnp-4366	20	76	learning	learning	NOUN
fnp-4366	20	77	based	base	VERB
fnp-4366	20	78	cerebrospinal	cerebrospinal	ADJ
fnp-4366	20	79	fluid	fluid	ADJ
fnp-4366	20	80	diagnostics	diagnostic	NOUN
fnp-4366	20	81	1.07	1.07	NUM
fnp-4366	20	82	proteomic	proteomic	ADJ
fnp-4366	20	83	profiling	profiling	NOUN
fnp-4366	20	84	of	of	ADP
fnp-4366	20	85	idh	idh	NOUN
fnp-4366	20	86	-	-	PUNCT
fnp-4366	20	87	mutant	mutant	NOUN
fnp-4366	20	88	gliomas	glioma	NOUN
fnp-4366	20	89	identifies	identify	VERB
fnp-4366	20	90	hip1r	hip1r	NOUN
fnp-4366	20	91	/	/	SYM
fnp-4366	20	92	vimentin	vimentin	NOUN
fnp-4366	20	93	as	as	ADP
fnp-4366	20	94	surrogate	surrogate	ADJ
fnp-4366	20	95	markers	marker	NOUN
fnp-4366	20	96	for	for	ADP
fnp-4366	20	97	1p/19q	1p/19q	PROPN
fnp-4366	20	98	codeletion	codeletion	NOUN
fnp-4366	20	99	and	and	CCONJ
fnp-4366	20	100	enables	enable	VERB
fnp-4366	20	101	prediction	prediction	NOUN
fnp-4366	20	102	of	of	ADP
fnp-4366	20	103	chromosomal	chromosomal	ADJ
fnp-4366	20	104	copy	copy	NOUN
fnp-4366	20	105	number	number	NOUN
fnp-4366	20	106	variations	variation	NOUN
fnp-4366	20	107	1.08	1.08	NUM
fnp-4366	20	108	cellular	cellular	ADJ
fnp-4366	20	109	digital	digital	ADJ
fnp-4366	20	110	neuropathology	neuropathology	NOUN
fnp-4366	20	111	2	2	NUM
fnp-4366	20	112	.	.	PUNCT
fnp-4366	20	113	neurooncology	neurooncology	NOUN
fnp-4366	20	114	2.01	2.01	NUM
fnp-4366	20	115	using	use	VERB
fnp-4366	20	116	spatial	spatial	ADJ
fnp-4366	20	117	transciptomics	transciptomic	NOUN
fnp-4366	20	118	for	for	ADP
fnp-4366	20	119	diagnostic	diagnostic	ADJ
fnp-4366	20	120	analysis	analysis	NOUN
fnp-4366	20	121	of	of	ADP
fnp-4366	20	122	glioma	glioma	NOUN
fnp-4366	20	123	2.02	2.02	NUM
fnp-4366	20	124	single	single	ADJ
fnp-4366	20	125	cell	cell	NOUN
fnp-4366	20	126	dna	dna	NOUN
fnp-4366	20	127	amplicon	amplicon	NOUN
fnp-4366	20	128	sequencing	sequencing	NOUN
fnp-4366	20	129	reveals	reveal	VERB
fnp-4366	20	130	order	order	NOUN
fnp-4366	20	131	of	of	ADP
fnp-4366	20	132	mutational	mutational	ADJ
fnp-4366	20	133	acquisition	acquisition	NOUN
fnp-4366	20	134	in	in	ADP
fnp-4366	20	135	traf7	traf7	PROPN
fnp-4366	20	136	and	and	CCONJ
fnp-4366	20	137	klf4	klf4	PROPN
fnp-4366	20	138	or	or	CCONJ
fnp-4366	20	139	akt1	akt1	PROPN
fnp-4366	20	140	co	co	VERB
fnp-4366	20	141	-	-	ADJ
fnp-4366	20	142	mutated	mutate	VERB
fnp-4366	20	143	meningiomas	meningioma	NOUN
fnp-4366	20	144	2.03	2.03	NUM
fnp-4366	20	145	alterations	alteration	NOUN
fnp-4366	20	146	in	in	ADP
fnp-4366	20	147	ptpn11	ptpn11	NOUN
fnp-4366	20	148	and	and	CCONJ
fnp-4366	20	149	other	other	ADJ
fnp-4366	20	150	noonan	noonan	PROPN
fnp-4366	20	151	syndrome	syndrome	PROPN
fnp-4366	21	1	associated	associate	VERB
fnp-4366	21	2	map	map	PROPN
fnp-4366	21	3	-	-	PUNCT
fnp-4366	21	4	kinase	kinase	NOUN
fnp-4366	21	5	signaling	signal	VERB
fnp-4366	21	6	pathway	pathway	NOUN
fnp-4366	21	7	genes	gene	NOUN
fnp-4366	21	8	accumulate	accumulate	VERB
fnp-4366	21	9	in	in	ADP
fnp-4366	21	10	histopathologically	histopathologically	ADV
fnp-4366	21	11	atypical	atypical	ADJ
fnp-4366	21	12	ganglioglioma	ganglioglioma	NOUN
fnp-4366	21	13	with	with	ADP
fnp-4366	21	14	adverse	adverse	ADJ
fnp-4366	21	15	postsurgical	postsurgical	ADJ
fnp-4366	21	16	outcome	outcome	NOUN
fnp-4366	21	17	2.04	2.04	NUM
fnp-4366	21	18	molecular	molecular	ADJ
fnp-4366	21	19	refinement	refinement	NOUN
fnp-4366	21	20	of	of	ADP
fnp-4366	21	21	pilocytic	pilocytic	ADJ
fnp-4366	21	22	astrocytoma	astrocytoma	NOUN
fnp-4366	21	23	in	in	ADP
fnp-4366	21	24	adult	adult	NOUN
fnp-4366	21	25	patients	patient	NOUN
fnp-4366	21	26	2.05	2.05	NUM
fnp-4366	21	27	exploration	exploration	NOUN
fnp-4366	21	28	of	of	ADP
fnp-4366	21	29	cellular	cellular	ADJ
fnp-4366	21	30	origins	origin	NOUN
fnp-4366	21	31	and	and	CCONJ
fnp-4366	21	32	therapeutic	therapeutic	ADJ
fnp-4366	21	33	targets	target	NOUN
fnp-4366	21	34	by	by	ADP
fnp-4366	21	35	modeling	model	VERB
fnp-4366	21	36	high	high	ADJ
fnp-4366	21	37	grade	grade	NOUN
fnp-4366	21	38	pediatric	pediatric	ADJ
fnp-4366	21	39	glioma	glioma	NOUN
fnp-4366	21	40	of	of	ADP
fnp-4366	21	41	the	the	DET
fnp-4366	21	42	mycn	mycn	NOUN
fnp-4366	21	43	subclass	subclass	NOUN
fnp-4366	21	44	in	in	ADP
fnp-4366	21	45	mice	mice	NOUN
fnp-4366	21	46	2.06	2.06	NUM
fnp-4366	21	47	the	the	DET
fnp-4366	21	48	genomic	genomic	NOUN
fnp-4366	21	49	and	and	CCONJ
fnp-4366	21	50	transcriptional	transcriptional	ADJ
fnp-4366	21	51	landscape	landscape	NOUN
fnp-4366	21	52	of	of	ADP
fnp-4366	21	53	primary	primary	ADJ
fnp-4366	21	54	central	central	ADJ
fnp-4366	21	55	nervous	nervous	ADJ
fnp-4366	21	56	system	system	NOUN
fnp-4366	21	57	lymphoma	lymphoma	VERB
fnp-4366	21	58	2.07	2.07	NUM
fnp-4366	21	59	pmolecular	pmolecular	ADJ
fnp-4366	21	60	mechanisms	mechanism	NOUN
fnp-4366	21	61	of	of	ADP
fnp-4366	21	62	therapy	therapy	NOUN
fnp-4366	21	63	resistance	resistance	NOUN
fnp-4366	21	64	in	in	ADP
fnp-4366	21	65	malignant	malignant	ADJ
fnp-4366	21	66	melanoma	melanoma	NOUN
fnp-4366	21	67	brain	brain	NOUN
fnp-4366	21	68	metastasis	metastasis	NOUN
fnp-4366	21	69	2.08	2.08	NUM
fnp-4366	21	70	a	a	DET
fnp-4366	21	71	peripheral	peripheral	ADJ
fnp-4366	21	72	nerve	nerve	NOUN
fnp-4366	21	73	sheath	sheath	NOUN
fnp-4366	21	74	tumor	tumor	NOUN
fnp-4366	21	75	syndrome	syndrome	NOUN
fnp-4366	21	76	caused	cause	VERB
fnp-4366	21	77	by	by	ADP
fnp-4366	21	78	postzygotic	postzygotic	ADJ
fnp-4366	21	79	erbb2	erbb2	PROPN
fnp-4366	21	80	mutations	mutation	NOUN
fnp-4366	21	81	2.09	2.09	NUM
fnp-4366	21	82	cns	cns	NOUN
fnp-4366	21	83	-	-	PUNCT
fnp-4366	21	84	tumor	tumor	NOUN
fnp-4366	21	85	patients	patient	NOUN
fnp-4366	21	86	within	within	ADP
fnp-4366	21	87	the	the	DET
fnp-4366	21	88	impress	impress	NOUN
fnp-4366	21	89	-	-	PUNCT
fnp-4366	21	90	norway	norway	NOUN
fnp-4366	21	91	trial	trial	NOUN
fnp-4366	21	92	:	:	PUNCT
fnp-4366	21	93	first	first	ADJ
fnp-4366	21	94	year	year	NOUN
fnp-4366	21	95	experiences	experience	VERB
fnp-4366	21	96	3	3	NUM
fnp-4366	21	97	.	.	PUNCT
fnp-4366	21	98	neurodegeneration	neurodegeneration	NOUN
fnp-4366	21	99	3.01	3.01	NUM
fnp-4366	21	100	cnn	cnn	PROPN
fnp-4366	21	101	-	-	PUNCT
fnp-4366	21	102	supported	support	VERB
fnp-4366	21	103	quantification	quantification	NOUN
fnp-4366	21	104	of	of	ADP
fnp-4366	21	105	fat	fat	ADJ
fnp-4366	21	106	compartments	compartment	NOUN
fnp-4366	21	107	at	at	ADP
fnp-4366	21	108	abdominal	abdominal	ADJ
fnp-4366	21	109	mri	mri	NOUN
fnp-4366	21	110	applied	apply	VERB
fnp-4366	21	111	to	to	PART
fnp-4366	21	112	als	als	VERB
fnp-4366	21	113	patients	patient	NOUN
fnp-4366	21	114	3.02	3.02	NUM
fnp-4366	21	115	neurodegenerative	neurodegenerative	ADJ
fnp-4366	21	116	iron	iron	NOUN
fnp-4366	21	117	storage	storage	NOUN
fnp-4366	21	118	disease	disease	NOUN
fnp-4366	21	119	(	(	PUNCT
fnp-4366	21	120	neuroferritinopathy	neuroferritinopathy	ADJ
fnp-4366	21	121	)	)	PUNCT
fnp-4366	21	122	caused	cause	VERB
fnp-4366	21	123	by	by	ADP
fnp-4366	21	124	a	a	DET
fnp-4366	21	125	novel	novel	ADJ
fnp-4366	21	126	frameshift	frameshift	NOUN
fnp-4366	21	127	mutation	mutation	NOUN
fnp-4366	21	128	in	in	ADP
fnp-4366	21	129	the	the	DET
fnp-4366	21	130	ferritin	ferritin	ADJ
fnp-4366	21	131	heavy	heavy	ADJ
fnp-4366	21	132	chain	chain	NOUN
fnp-4366	21	133	gene	gene	NOUN
fnp-4366	21	134	(	(	PUNCT
fnp-4366	21	135	fth1	fth1	PROPN
fnp-4366	21	136	c.341	c.341	PROPN
fnp-4366	21	137	-	-	PUNCT
fnp-4366	21	138	342del	342del	NUM
fnp-4366	21	139	)	)	PUNCT
fnp-4366	21	140	3.03	3.03	NUM
fnp-4366	21	141	the	the	DET
fnp-4366	21	142	contribution	contribution	NOUN
fnp-4366	21	143	of	of	ADP
fnp-4366	21	144	late	late	ADJ
fnp-4366	21	145	-	-	PUNCT
fnp-4366	21	146	nc	nc	PROPN
fnp-4366	21	147	to	to	PART
fnp-4366	21	148	neuron	neuron	VERB
fnp-4366	21	149	loss	loss	NOUN
fnp-4366	21	150	,	,	PUNCT
fnp-4366	21	151	granulovacuolar	granulovacuolar	ADJ
fnp-4366	21	152	degeneration	degeneration	NOUN
fnp-4366	21	153	and	and	CCONJ
fnp-4366	21	154	dementia	dementia	NOUN
fnp-4366	21	155	in	in	ADP
fnp-4366	21	156	alzheimer	alzheimer	PROPN
fnp-4366	21	157	’s	’s	PART
fnp-4366	21	158	disease	disease	NOUN
fnp-4366	21	159	3.04	3.04	NUM
fnp-4366	21	160	the	the	DET
fnp-4366	21	161	role	role	NOUN
fnp-4366	21	162	of	of	ADP
fnp-4366	21	163	c3	c3	PROPN
fnp-4366	21	164	inhibition	inhibition	NOUN
fnp-4366	21	165	in	in	ADP
fnp-4366	21	166	an	an	DET
fnp-4366	21	167	ipsc	ipsc	NOUN
fnp-4366	21	168	nmj	nmj	PROPN
fnp-4366	21	169	model	model	NOUN
fnp-4366	21	170	of	of	ADP
fnp-4366	21	171	neuroinflammation	neuroinflammation	NOUN
fnp-4366	21	172	3.05	3.05	NUM
fnp-4366	21	173	fast	fast	ADJ
fnp-4366	21	174	-	-	PUNCT
fnp-4366	21	175	track	track	NOUN
fnp-4366	21	176	procedure	procedure	NOUN
fnp-4366	21	177	for	for	ADP
fnp-4366	21	178	the	the	DET
fnp-4366	21	179	neuropathological	neuropathological	ADJ
fnp-4366	21	180	assessment	assessment	NOUN
fnp-4366	21	181	of	of	ADP
fnp-4366	21	182	neurodegenerative	neurodegenerative	ADJ
fnp-4366	21	183	diseases	disease	NOUN
fnp-4366	21	184	3.06	3.06	NUM
fnp-4366	21	185	neurodegeneration	neurodegeneration	NOUN
fnp-4366	21	186	in	in	ADP
fnp-4366	21	187	hsan1	hsan1	NOUN
fnp-4366	21	188	due	due	ADP
fnp-4366	21	189	to	to	ADP
fnp-4366	21	190	atl1	atl1	PROPN
fnp-4366	21	191	(	(	PUNCT
fnp-4366	21	192	gly66gln	gly66gln	PROPN
fnp-4366	21	193	)	)	PUNCT
fnp-4366	21	194	mutation	mutation	NOUN
fnp-4366	21	195	is	be	AUX
fnp-4366	21	196	associated	associate	VERB
fnp-4366	21	197	with	with	ADP
fnp-4366	21	198	defective	defective	ADJ
fnp-4366	21	199	erprotein	erprotein	NOUN
fnp-4366	21	200	quality	quality	NOUN
fnp-4366	21	201	control	control	NOUN
fnp-4366	21	202	and	and	CCONJ
fnp-4366	21	203	compromised	compromise	VERB
fnp-4366	21	204	autophagy	autophagy	ADV
fnp-4366	21	205	3.07	3.07	NUM
fnp-4366	21	206	single	single	ADJ
fnp-4366	21	207	-	-	PUNCT
fnp-4366	21	208	nucleus	nucleus	NOUN
fnp-4366	21	209	chromatin	chromatin	NOUN
fnp-4366	21	210	accessibility	accessibility	NOUN
fnp-4366	21	211	profiling	profiling	NOUN
fnp-4366	21	212	in	in	ADP
fnp-4366	21	213	four	four	NUM
fnp-4366	21	214	-	-	PUNCT
fnp-4366	21	215	repeat	repeat	NOUN
fnp-4366	21	216	tauopathies	tauopathie	NOUN
fnp-4366	21	217	3.08	3.08	NUM
fnp-4366	21	218	application	application	NOUN
fnp-4366	21	219	of	of	ADP
fnp-4366	21	220	a	a	DET
fnp-4366	21	221	human	human	ADJ
fnp-4366	21	222	stem	stem	NOUN
fnp-4366	21	223	cell	cell	NOUN
fnp-4366	21	224	transplantation	transplantation	NOUN
fnp-4366	21	225	model	model	NOUN
fnp-4366	21	226	of	of	ADP
fnp-4366	21	227	alzheimer	alzheimer	PROPN
fnp-4366	21	228	’s	’s	PART
fnp-4366	21	229	disease	disease	NOUN
fnp-4366	21	230	to	to	PART
fnp-4366	21	231	examine	examine	VERB
fnp-4366	21	232	disease	disease	NOUN
fnp-4366	21	233	-	-	PUNCT
fnp-4366	21	234	associated	associate	VERB
fnp-4366	21	235	changes	change	NOUN
fnp-4366	21	236	at	at	ADP
fnp-4366	21	237	a	a	DET
fnp-4366	21	238	single	single	ADJ
fnp-4366	21	239	cell	cell	NOUN
fnp-4366	21	240	level	level	NOUN
fnp-4366	21	241	in	in	ADP
fnp-4366	21	242	vivo	vivo	ADJ
fnp-4366	21	243	4	4	NUM
fnp-4366	21	244	.	.	PUNCT
fnp-4366	21	245	neuroinflammation	neuroinflammation	NOUN
fnp-4366	21	246	4.01	4.01	NUM
fnp-4366	21	247	pathological	pathological	ADJ
fnp-4366	21	248	and	and	CCONJ
fnp-4366	21	249	genetic	genetic	ADJ
fnp-4366	21	250	characterization	characterization	NOUN
fnp-4366	21	251	of	of	ADP
fnp-4366	21	252	jc	jc	PROPN
fnp-4366	21	253	virus	virus	NOUN
fnp-4366	21	254	encephalopathy	encephalopathy	ADJ
fnp-4366	21	255	with	with	ADP
fnp-4366	21	256	an	an	DET
fnp-4366	21	257	eleven	eleven	NUM
fnp-4366	21	258	-	-	PUNCT
fnp-4366	21	259	year	year	NOUN
fnp-4366	21	260	-	-	PUNCT
fnp-4366	21	261	long	long	ADJ
fnp-4366	21	262	disease	disease	NOUN
fnp-4366	21	263	course	course	NOUN
fnp-4366	21	264	4.02	4.02	NUM
fnp-4366	21	265	reduction	reduction	NOUN
fnp-4366	21	266	of	of	ADP
fnp-4366	21	267	oligodendrocyte	oligodendrocyte	ADJ
fnp-4366	21	268	populations	population	NOUN
fnp-4366	21	269	in	in	ADP
fnp-4366	21	270	patients	patient	NOUN
fnp-4366	21	271	with	with	ADP
fnp-4366	21	272	late	late	ADJ
fnp-4366	21	273	-	-	PUNCT
fnp-4366	21	274	onset	onset	NOUN
fnp-4366	21	275	multiple	multiple	ADJ
fnp-4366	21	276	sclerosis	sclerosis	NOUN
fnp-4366	21	277	4.03	4.03	NUM
fnp-4366	21	278	schwann	schwann	PROPN
fnp-4366	21	279	cell	cell	NOUN
fnp-4366	21	280	remyelination	remyelination	NOUN
fnp-4366	21	281	is	be	AUX
fnp-4366	21	282	a	a	DET
fnp-4366	21	283	salient	salient	ADJ
fnp-4366	21	284	feature	feature	NOUN
fnp-4366	21	285	of	of	ADP
fnp-4366	21	286	spinal	spinal	ADJ
fnp-4366	21	287	nmo	nmo	NOUN
fnp-4366	21	288	with	with	ADP
fnp-4366	21	289	neuroprotective	neuroprotective	ADJ
fnp-4366	21	290	potential	potential	ADJ
fnp-4366	21	291	5	5	NUM
fnp-4366	21	292	.	.	PUNCT
fnp-4366	21	293	muscle	muscle	NOUN
fnp-4366	21	294	/	/	SYM
fnp-4366	21	295	nerve	nerve	NOUN
fnp-4366	21	296	5.01	5.01	NUM
fnp-4366	21	297	molecular	molecular	ADJ
fnp-4366	21	298	profiling	profiling	NOUN
fnp-4366	21	299	of	of	ADP
fnp-4366	21	300	skeletal	skeletal	ADJ
fnp-4366	21	301	muscle	muscle	NOUN
fnp-4366	21	302	in	in	ADP
fnp-4366	21	303	infantile	infantile	ADJ
fnp-4366	21	304	,	,	PUNCT
fnp-4366	21	305	juvenile	juvenile	ADJ
fnp-4366	21	306	and	and	CCONJ
fnp-4366	21	307	adult	adult	NOUN
fnp-4366	21	308	patients	patient	NOUN
fnp-4366	21	309	with	with	ADP
fnp-4366	21	310	pompe	pompe	PROPN
fnp-4366	21	311	disease	disease	NOUN
fnp-4366	21	312	5.02	5.02	NUM
fnp-4366	21	313	expression	expression	NOUN
fnp-4366	21	314	of	of	ADP
fnp-4366	21	315	immune	immune	ADJ
fnp-4366	21	316	regulating	regulate	VERB
fnp-4366	21	317	proteins	protein	NOUN
fnp-4366	21	318	in	in	ADP
fnp-4366	21	319	skeletal	skeletal	ADJ
fnp-4366	21	320	muscle	muscle	NOUN
fnp-4366	21	321	of	of	ADP
fnp-4366	21	322	different	different	ADJ
fnp-4366	21	323	idiopathic	idiopathic	ADJ
fnp-4366	21	324	inflammatory	inflammatory	ADJ
fnp-4366	21	325	myopathies	myopathy	NOUN
fnp-4366	21	326	(	(	PUNCT
fnp-4366	21	327	iim	iim	NOUN
fnp-4366	21	328	)	)	PUNCT
fnp-4366	21	329	subtypes	subtype	NOUN
fnp-4366	21	330	5.03	5.03	NUM
fnp-4366	21	331	long	long	ADJ
fnp-4366	21	332	term	term	NOUN
fnp-4366	21	333	safety	safety	NOUN
fnp-4366	21	334	and	and	CCONJ
fnp-4366	21	335	efficacy	efficacy	NOUN
fnp-4366	21	336	outcomes	outcome	NOUN
fnp-4366	21	337	for	for	ADP
fnp-4366	21	338	x	x	VERB
fnp-4366	21	339	-	-	VERB
fnp-4366	21	340	linked	link	VERB
fnp-4366	21	341	myotubular	myotubular	ADJ
fnp-4366	21	342	myopathy	myopathy	ADJ
fnp-4366	21	343	(	(	PUNCT
fnp-4366	21	344	xlmtm	xlmtm	PROPN
fnp-4366	21	345	)	)	PUNCT
fnp-4366	21	346	with	with	ADP
fnp-4366	21	347	gene	gene	NOUN
fnp-4366	21	348	replacement	replacement	NOUN
fnp-4366	21	349	therapy	therapy	NOUN
fnp-4366	21	350	,	,	PUNCT
fnp-4366	21	351	resamirigene	resamirigene	NOUN
fnp-4366	21	352	bilparvovec	bilparvovec	PROPN
fnp-4366	21	353	(	(	PUNCT
fnp-4366	21	354	aspiro	aspiro	ADJ
fnp-4366	21	355	):	):	PUNCT
fnp-4366	21	356	preliminary	preliminary	ADJ
fnp-4366	21	357	results	result	NOUN
fnp-4366	21	358	from	from	ADP
fnp-4366	21	359	cohort	cohort	NOUN
fnp-4366	21	360	1	1	NUM
fnp-4366	21	361	in	in	ADP
fnp-4366	21	362	aspiro	aspiro	ADJ
fnp-4366	21	363	,	,	PUNCT
fnp-4366	21	364	a	a	DET
fnp-4366	21	365	phase	phase	NOUN
fnp-4366	21	366	1/2/3	1/2/3	NUM
fnp-4366	21	367	study	study	NOUN
fnp-4366	21	368	5.04	5.04	NUM
fnp-4366	21	369	lymphotoxin	lymphotoxin	NOUN
fnp-4366	21	370	-	-	PUNCT
fnp-4366	21	371	driven	drive	VERB
fnp-4366	21	372	chronic	chronic	ADJ
fnp-4366	21	373	mucle	mucle	NOUN
fnp-4366	21	374	inflammation	inflammation	NOUN
fnp-4366	21	375	interdepends	interdepend	NOUN
fnp-4366	21	376	with	with	ADP
fnp-4366	21	377	impaired	impaired	ADJ
fnp-4366	21	378	autophagy	autophagy	NOUN
fnp-4366	21	379	,	,	PUNCT
fnp-4366	21	380	self	self	NOUN
fnp-4366	21	381	-	-	PUNCT
fnp-4366	21	382	perpetuates	perpetuate	NOUN
fnp-4366	21	383	and	and	CCONJ
fnp-4366	21	384	models	model	VERB
fnp-4366	21	385	inclusion	inclusion	NOUN
fnp-4366	21	386	body	body	NOUN
fnp-4366	21	387	myositis	myositis	NOUN
fnp-4366	21	388	in	in	ADP
fnp-4366	21	389	mice	mice	NOUN
fnp-4366	21	390	5.05	5.05	NUM
fnp-4366	21	391	novel	novel	NOUN
fnp-4366	21	392	form	form	NOUN
fnp-4366	21	393	of	of	ADP
fnp-4366	21	394	congenital	congenital	ADJ
fnp-4366	21	395	myopathy	myopathy	NOUN
fnp-4366	21	396	caused	cause	VERB
fnp-4366	21	397	by	by	ADP
fnp-4366	21	398	bi	bi	ADJ
fnp-4366	21	399	-	-	ADJ
fnp-4366	21	400	allelic	allelic	ADJ
fnp-4366	21	401	mutations	mutation	NOUN
fnp-4366	21	402	in	in	ADP
fnp-4366	21	403	uncoordinated	uncoordinated	ADJ
fnp-4366	21	404	mutant	mutant	ADJ
fnp-4366	21	405	number-45	number-45	PROPN
fnp-4366	21	406	myosin	myosin	PROPN
fnp-4366	21	407	chaperone	chaperone	PROPN
fnp-4366	21	408	b	b	PROPN
fnp-4366	21	409	6	6	NUM
fnp-4366	21	410	.	.	PUNCT
fnp-4366	21	411	free	free	ADJ
fnp-4366	21	412	topics	topic	NOUN
fnp-4366	21	413	6.01	6.01	NUM
fnp-4366	21	414	deep	deep	ADJ
fnp-4366	21	415	genotype	genotype	NOUN
fnp-4366	21	416	-	-	PUNCT
fnp-4366	21	417	phenotype	phenotype	NOUN
fnp-4366	21	418	analysis	analysis	NOUN
fnp-4366	21	419	of	of	ADP
fnp-4366	21	420	focal	focal	ADJ
fnp-4366	21	421	cortical	cortical	ADJ
fnp-4366	21	422	dysplasia	dysplasia	NOUN
fnp-4366	21	423	type	type	NOUN
fnp-4366	21	424	2	2	NUM
fnp-4366	21	425	differentiates	differentiate	NOUN
fnp-4366	21	426	between	between	ADP
fnp-4366	21	427	a	a	DET
fnp-4366	21	428	gator	gator	NOUN
fnp-4366	21	429	-	-	PUNCT
fnp-4366	21	430	positive	positive	ADJ
fnp-4366	21	431	autophagy	autophagy	NOUN
fnp-4366	21	432	altered	alter	VERB
fnp-4366	21	433	subtype	subtype	NOUN
fnp-4366	21	434	2a	2a	NUM
fnp-4366	21	435	and	and	CCONJ
fnp-4366	21	436	mtor	mtor	NOUN
fnp-4366	21	437	-	-	PUNCT
fnp-4366	21	438	positive	positive	ADJ
fnp-4366	21	439	migration	migration	NOUN
fnp-4366	21	440	deficit	deficit	NOUN
fnp-4366	21	441	subtype	subtype	NOUN
fnp-4366	21	442	2b	2b	NUM
fnp-4366	21	443	6.02	6.02	NUM
fnp-4366	21	444	age	age	NOUN
fnp-4366	21	445	-	-	PUNCT
fnp-4366	21	446	dependent	dependent	ADJ
fnp-4366	21	447	increase	increase	NOUN
fnp-4366	21	448	of	of	ADP
fnp-4366	21	449	perineuronal	perineuronal	ADJ
fnp-4366	21	450	nets	net	NOUN
fnp-4366	21	451	in	in	ADP
fnp-4366	21	452	the	the	DET
fnp-4366	21	453	human	human	ADJ
fnp-4366	21	454	hippocampus	hippocampus	NOUN
fnp-4366	21	455	of	of	ADP
fnp-4366	21	456	patients	patient	NOUN
fnp-4366	21	457	with	with	ADP
fnp-4366	21	458	and	and	CCONJ
fnp-4366	21	459	without	without	ADP
fnp-4366	21	460	temporal	temporal	ADJ
fnp-4366	21	461	lobe	lobe	NOUN
fnp-4366	21	462	epilepsy	epilepsy	NOUN
fnp-4366	21	463	6.03	6.03	NUM
fnp-4366	21	464	vakuolisierung	vakuolisierung	PROPN
fnp-4366	21	465	der	der	ADJ
fnp-4366	21	466	dura	dura	NOUN
fnp-4366	21	467	als	als	VERB
fnp-4366	21	468	nicht	nicht	NOUN
fnp-4366	21	469	-	-	PUNCT
fnp-4366	21	470	lymphassoziierte	lymphassoziierte	NOUN
fnp-4366	21	471	veränderung	veränderung	PROPN
fnp-4366	21	472	6.04	6.04	NUM
fnp-4366	21	473	moghe	moghe	NOUN
fnp-4366	21	474	with	with	ADP
fnp-4366	21	475	or	or	CCONJ
fnp-4366	21	476	without	without	ADP
fnp-4366	21	477	slc35a2	slc35a2	NOUN
fnp-4366	21	478	brain	brain	NOUN
fnp-4366	21	479	somatic	somatic	ADJ
fnp-4366	21	480	mutations	mutation	NOUN
fnp-4366	21	481	reveal	reveal	VERB
fnp-4366	21	482	a	a	DET
fnp-4366	21	483	common	common	ADJ
fnp-4366	21	484	phenotype	phenotype	NOUN
fnp-4366	21	485	of	of	ADP
fnp-4366	21	486	oligodendroglial	oligodendroglial	ADJ
fnp-4366	21	487	regeneration	regeneration	NOUN
fnp-4366	21	488	and	and	CCONJ
fnp-4366	21	489	remyelination	remyelination	NOUN
fnp-4366	21	490	    	    	SPACE
fnp-4366	21	491	1	1	NUM
fnp-4366	21	492	.	.	PUNCT
fnp-4366	22	1	new	new	ADJ
fnp-4366	22	2	diagnostic	diagnostic	ADJ
fnp-4366	22	3	methods	method	NOUN
fnp-4366	22	4	1.01	1.01	NUM
fnp-4366	22	5	free	free	ADJ
fnp-4366	22	6	neuropathol	neuropathol	NOUN
fnp-4366	22	7	3:20:5	3:20:5	NUM
fnp-4366	22	8	methylthioadenosine	methylthioadenosine	ADJ
fnp-4366	22	9	phosphorylase	phosphorylase	NOUN
fnp-4366	22	10	immunostaining	immunostaine	VERB
fnp-4366	22	11	as	as	ADP
fnp-4366	22	12	a	a	DET
fnp-4366	22	13	surrogate	surrogate	ADJ
fnp-4366	22	14	marker	marker	NOUN
fnp-4366	22	15	for	for	ADP
fnp-4366	22	16	cdkn2a	cdkn2a	PROPN
fnp-4366	22	17	/	/	SYM
fnp-4366	22	18	b	b	NOUN
fnp-4366	22	19	homozygous	homozygous	ADJ
fnp-4366	22	20	deletion	deletion	NOUN
fnp-4366	22	21	in	in	ADP
fnp-4366	22	22	gliomas	glioma	NOUN
fnp-4366	22	23	theoni	theoni	VERB
fnp-4366	22	24	maragkou1	maragkou1	NOUN
fnp-4366	22	25	,	,	PUNCT
fnp-4366	22	26	ekkehard	ekkehard	PROPN
fnp-4366	22	27	hewer1,2	hewer1,2	PROPN
fnp-4366	22	28	,	,	PUNCT
fnp-4366	22	29	erik	erik	PROPN
fnp-4366	22	30	vassella1	vassella1	PROPN
fnp-4366	22	31	,	,	PUNCT
fnp-4366	22	32	baptiste	baptiste	PROPN
fnp-4366	22	33	pasquier1	pasquier1	PROPN
fnp-4366	22	34	,	,	PUNCT
fnp-4366	22	35	stefan	stefan	PROPN
fnp-4366	22	36	reinhard1	reinhard1	PROPN
fnp-4366	22	37	,	,	PUNCT
fnp-4366	22	38	maja	maja	PROPN
fnp-4366	22	39	neuenschwander1	neuenschwander1	PROPN
fnp-4366	22	40	,	,	PUNCT
fnp-4366	22	41	philippe	philippe	PROPN
fnp-4366	22	42	schucht3	schucht3	VERB
fnp-4366	22	43	1	1	NUM
fnp-4366	22	44	university	university	NOUN
fnp-4366	22	45	of	of	ADP
fnp-4366	22	46	bern	bern	PROPN
fnp-4366	22	47	,	,	PUNCT
fnp-4366	22	48	institute	institute	PROPN
fnp-4366	22	49	of	of	ADP
fnp-4366	22	50	pathology	pathology	PROPN
fnp-4366	22	51	,	,	PUNCT
fnp-4366	22	52	institute	institute	PROPN
fnp-4366	22	53	of	of	ADP
fnp-4366	22	54	pathology	pathology	PROPN
fnp-4366	22	55	,	,	PUNCT
fnp-4366	22	56	bern	bern	PROPN
fnp-4366	22	57	,	,	PUNCT
fnp-4366	22	58	switzerland	switzerland	PROPN
fnp-4366	22	59	2	2	NUM
fnp-4366	22	60	lausanne	lausanne	PROPN
fnp-4366	22	61	university	university	PROPN
fnp-4366	22	62	hospital	hospital	NOUN
fnp-4366	22	63	,	,	PUNCT
fnp-4366	22	64	institute	institute	NOUN
fnp-4366	22	65	of	of	ADP
fnp-4366	22	66	pathology	pathology	PROPN
fnp-4366	22	67	,	,	PUNCT
fnp-4366	22	68	institute	institute	PROPN
fnp-4366	22	69	of	of	ADP
fnp-4366	22	70	pathology	pathology	PROPN
fnp-4366	22	71	,	,	PUNCT
fnp-4366	22	72	lausanne	lausanne	PROPN
fnp-4366	22	73	,	,	PUNCT
fnp-4366	22	74	switzerland	switzerland	PROPN
fnp-4366	22	75	3	3	NUM
fnp-4366	22	76	inselspital	inselspital	PROPN
fnp-4366	22	77	,	,	PUNCT
fnp-4366	22	78	bern	bern	PROPN
fnp-4366	22	79	university	university	PROPN
fnp-4366	22	80	hospital	hospital	NOUN
fnp-4366	22	81	,	,	PUNCT
fnp-4366	22	82	dept	dept	NOUN
fnp-4366	22	83	.	.	PROPN
fnp-4366	22	84	of	of	ADP
fnp-4366	22	85	neurosurgery	neurosurgery	NOUN
fnp-4366	22	86	,	,	PUNCT
fnp-4366	22	87	dept	dept	NOUN
fnp-4366	22	88	.	.	PROPN
fnp-4366	22	89	of	of	ADP
fnp-4366	22	90	neurosurgery	neurosurgery	PROPN
fnp-4366	22	91	,	,	PUNCT
fnp-4366	22	92	bern	bern	PROPN
fnp-4366	22	93	,	,	PUNCT
fnp-4366	22	94	switzerland	switzerland	PROPN
fnp-4366	22	95	background	background	NOUN
fnp-4366	22	96	:	:	PUNCT
fnp-4366	22	97	homozygous	homozygous	ADJ
fnp-4366	22	98	deletion	deletion	NOUN
fnp-4366	22	99	(	(	PUNCT
fnp-4366	22	100	hd	hd	NOUN
fnp-4366	22	101	)	)	PUNCT
fnp-4366	22	102	of	of	ADP
fnp-4366	22	103	the	the	DET
fnp-4366	22	104	cdkn2a	cdkn2a	PROPN
fnp-4366	22	105	/	/	SYM
fnp-4366	22	106	b	b	NOUN
fnp-4366	22	107	locus	locus	NOUN
fnp-4366	22	108	has	have	AUX
fnp-4366	22	109	emerged	emerge	VERB
fnp-4366	22	110	as	as	ADP
fnp-4366	22	111	an	an	DET
fnp-4366	22	112	unfavorable	unfavorable	ADJ
fnp-4366	22	113	prognostic	prognostic	ADJ
fnp-4366	22	114	marker	marker	NOUN
fnp-4366	22	115	in	in	ADP
fnp-4366	22	116	diffuse	diffuse	ADJ
fnp-4366	22	117	gliomas	glioma	NOUN
fnp-4366	22	118	,	,	PUNCT
fnp-4366	22	119	both	both	CCONJ
fnp-4366	22	120	idh	idh	NOUN
fnp-4366	22	121	-	-	PUNCT
fnp-4366	22	122	mutant	mutant	NOUN
fnp-4366	22	123	and	and	CCONJ
fnp-4366	22	124	idh	idh	NOUN
fnp-4366	22	125	-	-	PUNCT
fnp-4366	22	126	wildtype	wildtype	NOUN
fnp-4366	22	127	.	.	PUNCT
fnp-4366	23	1	testing	test	VERB
fnp-4366	23	2	for	for	ADP
fnp-4366	23	3	cdkn2a	cdkn2a	PROPN
fnp-4366	23	4	/	/	SYM
fnp-4366	23	5	b	b	NOUN
fnp-4366	23	6	deletions	deletion	NOUN
fnp-4366	23	7	can	can	AUX
fnp-4366	23	8	be	be	AUX
fnp-4366	23	9	performed	perform	VERB
fnp-4366	23	10	by	by	ADP
fnp-4366	23	11	a	a	DET
fnp-4366	23	12	variety	variety	NOUN
fnp-4366	23	13	of	of	ADP
fnp-4366	23	14	approaches	approach	NOUN
fnp-4366	23	15	,	,	PUNCT
fnp-4366	23	16	including	include	VERB
fnp-4366	23	17	copy	copy	NOUN
fnp-4366	23	18	number	number	NOUN
fnp-4366	23	19	variation	variation	NOUN
fnp-4366	23	20	(	(	PUNCT
fnp-4366	23	21	cnv	cnv	NOUN
fnp-4366	23	22	)	)	PUNCT
fnp-4366	23	23	analysis	analysis	NOUN
fnp-4366	23	24	based	base	VERB
fnp-4366	23	25	on	on	ADP
fnp-4366	23	26	genome	genome	NOUN
fnp-4366	23	27	-	-	PUNCT
fnp-4366	23	28	wide	wide	ADJ
fnp-4366	23	29	dna	dna	PROPN
fnp-4366	23	30	methylation	methylation	NOUN
fnp-4366	23	31	data	datum	NOUN
fnp-4366	23	32	,	,	PUNCT
fnp-4366	23	33	next	next	ADJ
fnp-4366	23	34	generation	generation	NOUN
fnp-4366	23	35	sequencing	sequence	VERB
fnp-4366	23	36	(	(	PUNCT
fnp-4366	23	37	ngs	ng	NOUN
fnp-4366	23	38	)	)	PUNCT
fnp-4366	23	39	or	or	CCONJ
fnp-4366	23	40	fluorescence	fluorescence	NOUN
fnp-4366	23	41	in	in	ADP
fnp-4366	23	42	-	-	PUNCT
fnp-4366	23	43	situ	situ	NOUN
fnp-4366	23	44	hybridization	hybridization	NOUN
fnp-4366	23	45	(	(	PUNCT
fnp-4366	23	46	fish	fish	NOUN
fnp-4366	23	47	)	)	PUNCT
fnp-4366	23	48	,	,	PUNCT
fnp-4366	23	49	but	but	CCONJ
fnp-4366	23	50	questions	question	NOUN
fnp-4366	23	51	remain	remain	VERB
fnp-4366	23	52	regarding	regard	VERB
fnp-4366	23	53	the	the	DET
fnp-4366	23	54	accuracy	accuracy	NOUN
fnp-4366	23	55	of	of	ADP
fnp-4366	23	56	and	and	CCONJ
fnp-4366	23	57	correlation	correlation	NOUN
fnp-4366	23	58	between	between	ADP
fnp-4366	23	59	different	different	ADJ
fnp-4366	23	60	testing	testing	NOUN
fnp-4366	23	61	modalities	modality	NOUN
fnp-4366	23	62	.	.	PUNCT
fnp-4366	24	1	aims	aim	VERB
fnp-4366	24	2	:	:	PUNCT
fnp-4366	24	3	in	in	ADP
fnp-4366	24	4	this	this	DET
fnp-4366	24	5	study	study	NOUN
fnp-4366	24	6	,	,	PUNCT
fnp-4366	24	7	we	we	PRON
fnp-4366	24	8	assessed	assess	VERB
fnp-4366	24	9	the	the	DET
fnp-4366	24	10	utility	utility	NOUN
fnp-4366	24	11	of	of	ADP
fnp-4366	24	12	s	s	NOUN
fnp-4366	24	13	-	-	PUNCT
fnp-4366	24	14	methyl-5'-thioadenosine	methyl-5'-thioadenosine	NOUN
fnp-4366	24	15	phosphorylase	phosphorylase	NOUN
fnp-4366	24	16	(	(	PUNCT
fnp-4366	24	17	mtap	mtap	ADJ
fnp-4366	24	18	)	)	PUNCT
fnp-4366	24	19	and	and	CCONJ
fnp-4366	24	20	cellular	cellular	ADJ
fnp-4366	24	21	tumor	tumor	NOUN
fnp-4366	24	22	suppressor	suppressor	NOUN
fnp-4366	24	23	protein	protein	NOUN
fnp-4366	24	24	pl61nk4a	pl61nk4a	NOUN
fnp-4366	24	25	(	(	PUNCT
fnp-4366	24	26	p16	p16	NOUN
fnp-4366	24	27	)	)	PUNCT
fnp-4366	24	28	immunostaining	immunostaine	VERB
fnp-4366	24	29	as	as	ADP
fnp-4366	24	30	surrogate	surrogate	ADJ
fnp-4366	24	31	markers	marker	NOUN
fnp-4366	24	32	for	for	ADP
fnp-4366	24	33	cdkn2a	cdkn2a	PROPN
fnp-4366	24	34	/	/	SYM
fnp-4366	24	35	b	b	PROPN
fnp-4366	24	36	hd	hd	NOUN
fnp-4366	24	37	in	in	ADP
fnp-4366	24	38	gliomas	glioma	NOUN
fnp-4366	24	39	,	,	PUNCT
fnp-4366	24	40	across	across	ADP
fnp-4366	24	41	different	different	ADJ
fnp-4366	24	42	histological	histological	ADJ
fnp-4366	24	43	tumor	tumor	NOUN
fnp-4366	24	44	grades	grade	NOUN
fnp-4366	24	45	and	and	CCONJ
fnp-4366	24	46	idh	idh	NOUN
fnp-4366	24	47	mutation	mutation	NOUN
fnp-4366	24	48	status	status	NOUN
fnp-4366	24	49	.	.	PUNCT
fnp-4366	25	1	question	question	NOUN
fnp-4366	25	2	:	:	PUNCT
fnp-4366	25	3	are	be	AUX
fnp-4366	25	4	mtap	mtap	ADJ
fnp-4366	25	5	and	and	CCONJ
fnp-4366	25	6	p16	p16	VERB
fnp-4366	25	7	accurate	accurate	ADJ
fnp-4366	25	8	surrogate	surrogate	ADJ
fnp-4366	25	9	markers	marker	NOUN
fnp-4366	25	10	for	for	ADP
fnp-4366	25	11	cdkn2a	cdkn2a	PROPN
fnp-4366	25	12	/	/	SYM
fnp-4366	25	13	b	b	PROPN
fnp-4366	25	14	hd	hd	NOUN
fnp-4366	25	15	in	in	ADP
fnp-4366	25	16	gliomas	glioma	NOUN
fnp-4366	25	17	?	?	PUNCT
fnp-4366	26	1	methods	method	NOUN
fnp-4366	26	2	:	:	PUNCT
fnp-4366	26	3	idh1	idh1	PROPN
fnp-4366	26	4	r132h	r132h	PROPN
fnp-4366	26	5	,	,	PUNCT
fnp-4366	26	6	atrx	atrx	NOUN
fnp-4366	26	7	and	and	CCONJ
fnp-4366	26	8	mtap	mtap	ADJ
fnp-4366	26	9	immunohistochemistry	immunohistochemistry	NOUN
fnp-4366	26	10	was	be	AUX
fnp-4366	26	11	performed	perform	VERB
fnp-4366	26	12	on	on	ADP
fnp-4366	26	13	tissue	tissue	NOUN
fnp-4366	26	14	microarrays	microarray	NOUN
fnp-4366	26	15	(	(	PUNCT
fnp-4366	26	16	tmas	tmas	PROPN
fnp-4366	26	17	)	)	PUNCT
fnp-4366	26	18	of	of	ADP
fnp-4366	26	19	301	301	NUM
fnp-4366	26	20	diffuse	diffuse	ADJ
fnp-4366	26	21	gliomas	glioma	NOUN
fnp-4366	26	22	.	.	PUNCT
fnp-4366	27	1	survival	survival	NOUN
fnp-4366	27	2	analysis	analysis	NOUN
fnp-4366	27	3	was	be	AUX
fnp-4366	27	4	performed	perform	VERB
fnp-4366	27	5	to	to	PART
fnp-4366	27	6	assess	assess	VERB
fnp-4366	27	7	the	the	DET
fnp-4366	27	8	prognostic	prognostic	ADJ
fnp-4366	27	9	value	value	NOUN
fnp-4366	27	10	of	of	ADP
fnp-4366	27	11	mtap	mtap	NOUN
fnp-4366	27	12	.	.	PUNCT
fnp-4366	28	1	furthermore	furthermore	ADV
fnp-4366	28	2	,	,	PUNCT
fnp-4366	28	3	100	100	NUM
fnp-4366	28	4	consecutive	consecutive	ADJ
fnp-4366	28	5	cases	case	NOUN
fnp-4366	28	6	of	of	ADP
fnp-4366	28	7	gliomas	glioma	NOUN
fnp-4366	28	8	were	be	AUX
fnp-4366	28	9	collected	collect	VERB
fnp-4366	28	10	,	,	PUNCT
fnp-4366	28	11	in	in	ADP
fnp-4366	28	12	order	order	NOUN
fnp-4366	28	13	to	to	PART
fnp-4366	28	14	correlate	correlate	VERB
fnp-4366	28	15	mtap	mtap	ADJ
fnp-4366	28	16	and	and	CCONJ
fnp-4366	28	17	p16	p16	NOUN
fnp-4366	28	18	expression	expression	NOUN
fnp-4366	28	19	with	with	ADP
fnp-4366	28	20	the	the	DET
fnp-4366	28	21	cdkn2a	cdkn2a	PROPN
fnp-4366	28	22	/	/	SYM
fnp-4366	28	23	b	b	PROPN
fnp-4366	28	24	status	status	NOUN
fnp-4366	28	25	in	in	ADP
fnp-4366	28	26	cnv	cnv	PROPN
fnp-4366	28	27	plot	plot	NOUN
fnp-4366	28	28	of	of	ADP
fnp-4366	28	29	each	each	DET
fnp-4366	28	30	tumor	tumor	NOUN
fnp-4366	28	31	.	.	PUNCT
fnp-4366	29	1	results	result	NOUN
fnp-4366	29	2	:	:	PUNCT
fnp-4366	29	3	mtap	mtap	ADJ
fnp-4366	29	4	deficiency	deficiency	NOUN
fnp-4366	29	5	was	be	AUX
fnp-4366	29	6	associated	associate	VERB
fnp-4366	29	7	with	with	ADP
fnp-4366	29	8	shortened	shorten	VERB
fnp-4366	29	9	survival	survival	NOUN
fnp-4366	29	10	in	in	ADP
fnp-4366	29	11	idh	idh	NOUN
fnp-4366	29	12	-	-	PUNCT
fnp-4366	29	13	mutant	mutant	NOUN
fnp-4366	29	14	astrocytomas	astrocytoma	NOUN
fnp-4366	29	15	(	(	PUNCT
fnp-4366	29	16	n=75	n=75	PROPN
fnp-4366	29	17	;	;	PUNCT
fnp-4366	29	18	median	median	ADJ
fnp-4366	29	19	survival	survival	NOUN
fnp-4366	29	20	61	61	NUM
fnp-4366	29	21	vs.	vs.	ADP
fnp-4366	29	22	137	137	NUM
fnp-4366	29	23	months	month	NOUN
fnp-4366	29	24	;	;	PUNCT
fnp-4366	29	25	p<0.0001	p<0.0001	NOUN
fnp-4366	29	26	)	)	PUNCT
fnp-4366	29	27	,	,	PUNCT
fnp-4366	29	28	idh	idh	NOUN
fnp-4366	29	29	-	-	PUNCT
fnp-4366	29	30	mutant	mutant	NOUN
fnp-4366	29	31	oligodendrogliomas	oligodendroglioma	NOUN
fnp-4366	29	32	(	(	PUNCT
fnp-4366	29	33	n=59	n=59	NOUN
fnp-4366	29	34	;	;	PUNCT
fnp-4366	29	35	median	median	ADJ
fnp-4366	29	36	survival	survival	NOUN
fnp-4366	29	37	41	41	NUM
fnp-4366	29	38	vs.	vs.	ADP
fnp-4366	29	39	147	147	NUM
fnp-4366	29	40	months	month	NOUN
fnp-4366	29	41	;	;	PUNCT
fnp-4366	29	42	p<0.0001	p<0.0001	PRON
fnp-4366	29	43	)	)	PUNCT
fnp-4366	29	44	and	and	CCONJ
fnp-4366	29	45	idh	idh	PROPN
fnp-4366	29	46	-	-	PUNCT
fnp-4366	29	47	wildtype	wildtype	NOUN
fnp-4366	29	48	gliomas	glioma	NOUN
fnp-4366	29	49	(	(	PUNCT
fnp-4366	29	50	n=117	n=117	NUM
fnp-4366	29	51	;	;	PUNCT
fnp-4366	29	52	median	median	ADJ
fnp-4366	29	53	survival	survival	NOUN
fnp-4366	29	54	13	13	NUM
fnp-4366	29	55	vs.	vs.	ADP
fnp-4366	29	56	16	16	NUM
fnp-4366	29	57	months	month	NOUN
fnp-4366	29	58	;	;	PUNCT
fnp-4366	29	59	p=0.011	p=0.011	X
fnp-4366	29	60	)	)	PUNCT
fnp-4366	29	61	.	.	PUNCT
fnp-4366	30	1	in	in	ADP
fnp-4366	30	2	a	a	DET
fnp-4366	30	3	cohort	cohort	NOUN
fnp-4366	30	4	of	of	ADP
fnp-4366	30	5	100	100	NUM
fnp-4366	30	6	gliomas	glioma	NOUN
fnp-4366	30	7	,	,	PUNCT
fnp-4366	30	8	complete	complete	ADJ
fnp-4366	30	9	loss	loss	NOUN
fnp-4366	30	10	of	of	ADP
fnp-4366	30	11	mtap	mtap	NOUN
fnp-4366	30	12	and	and	CCONJ
fnp-4366	30	13	p16	p16	NOUN
fnp-4366	30	14	by	by	ADP
fnp-4366	30	15	immunohistochemistry	immunohistochemistry	NOUN
fnp-4366	30	16	was	be	AUX
fnp-4366	30	17	100	100	NUM
fnp-4366	30	18	%	%	NOUN
fnp-4366	30	19	and	and	CCONJ
fnp-4366	30	20	90	90	NUM
fnp-4366	30	21	%	%	NOUN
fnp-4366	30	22	sensitive	sensitive	ADJ
fnp-4366	30	23	as	as	ADV
fnp-4366	30	24	well	well	ADV
fnp-4366	30	25	as	as	ADP
fnp-4366	30	26	97	97	NUM
fnp-4366	30	27	%	%	NOUN
fnp-4366	30	28	and	and	CCONJ
fnp-4366	30	29	89	89	NUM
fnp-4366	30	30	%	%	NOUN
fnp-4366	30	31	specific	specific	ADJ
fnp-4366	30	32	for	for	ADP
fnp-4366	30	33	cdkn2a	cdkn2a	PROPN
fnp-4366	30	34	/	/	SYM
fnp-4366	30	35	b	b	PROPN
fnp-4366	30	36	hd	hd	PROPN
fnp-4366	30	37	,	,	PUNCT
fnp-4366	30	38	respectively	respectively	ADV
fnp-4366	30	39	,	,	PUNCT
fnp-4366	30	40	as	as	SCONJ
fnp-4366	30	41	identified	identify	VERB
fnp-4366	30	42	on	on	ADP
fnp-4366	30	43	cnv	cnv	PROPN
fnp-4366	30	44	plot	plot	NOUN
fnp-4366	30	45	derived	derive	VERB
fnp-4366	30	46	from	from	ADP
fnp-4366	30	47	genome	genome	NOUN
fnp-4366	30	48	-	-	PUNCT
fnp-4366	30	49	wide	wide	ADJ
fnp-4366	30	50	dna	dna	PROPN
fnp-4366	30	51	methylation	methylation	NOUN
fnp-4366	30	52	analysis	analysis	NOUN
fnp-4366	30	53	.	.	PUNCT
fnp-4366	31	1	two	two	NUM
fnp-4366	31	2	cases	case	NOUN
fnp-4366	31	3	with	with	ADP
fnp-4366	31	4	mtap	mtap	NOUN
fnp-4366	31	5	and	and	CCONJ
fnp-4366	31	6	p16	p16	NOUN
fnp-4366	31	7	loss	loss	NOUN
fnp-4366	31	8	of	of	ADP
fnp-4366	31	9	expression	expression	NOUN
fnp-4366	31	10	did	do	AUX
fnp-4366	31	11	not	not	PART
fnp-4366	31	12	demonstrate	demonstrate	VERB
fnp-4366	31	13	cdkn2a	cdkn2a	PROPN
fnp-4366	31	14	/	/	SYM
fnp-4366	31	15	b	b	PROPN
fnp-4366	31	16	hd	hd	PROPN
fnp-4366	31	17	in	in	ADP
fnp-4366	31	18	cnv	cnv	PROPN
fnp-4366	31	19	plot	plot	NOUN
fnp-4366	31	20	,	,	PUNCT
fnp-4366	31	21	however	however	SCONJ
fnp-4366	31	22	fish	fish	VERB
fnp-4366	31	23	analysis	analysis	NOUN
fnp-4366	31	24	confirmed	confirm	VERB
fnp-4366	31	25	the	the	DET
fnp-4366	31	26	hd	hd	NOUN
fnp-4366	31	27	for	for	ADP
fnp-4366	31	28	cdkn2a	cdkn2a	PROPN
fnp-4366	31	29	/	/	SYM
fnp-4366	31	30	b.	b.	PROPN
fnp-4366	31	31	conclusions	conclusion	NOUN
fnp-4366	31	32	:	:	PUNCT
fnp-4366	31	33	mtap	mtap	ADJ
fnp-4366	31	34	immunostaining	immunostaine	VERB
fnp-4366	31	35	is	be	AUX
fnp-4366	31	36	an	an	DET
fnp-4366	31	37	important	important	ADJ
fnp-4366	31	38	complement	complement	NOUN
fnp-4366	31	39	for	for	ADP
fnp-4366	31	40	diagnostic	diagnostic	ADJ
fnp-4366	31	41	work	work	NOUN
fnp-4366	31	42	-	-	PUNCT
fnp-4366	31	43	up	up	NOUN
fnp-4366	31	44	of	of	ADP
fnp-4366	31	45	gliomas	glioma	NOUN
fnp-4366	31	46	,	,	PUNCT
fnp-4366	31	47	because	because	SCONJ
fnp-4366	31	48	of	of	ADP
fnp-4366	31	49	its	its	PRON
fnp-4366	31	50	excellent	excellent	ADJ
fnp-4366	31	51	correlation	correlation	NOUN
fnp-4366	31	52	with	with	ADP
fnp-4366	31	53	cdkn2a	cdkn2a	PROPN
fnp-4366	31	54	/	/	SYM
fnp-4366	31	55	b	b	PROPN
fnp-4366	31	56	status	status	NOUN
fnp-4366	31	57	,	,	PUNCT
fnp-4366	31	58	robustness	robustness	NOUN
fnp-4366	31	59	,	,	PUNCT
fnp-4366	31	60	rapid	rapid	ADJ
fnp-4366	31	61	turnaround	turnaround	NOUN
fnp-4366	31	62	time	time	NOUN
fnp-4366	31	63	and	and	CCONJ
fnp-4366	31	64	low	low	ADJ
fnp-4366	31	65	-	-	PUNCT
fnp-4366	31	66	costs	cost	NOUN
fnp-4366	31	67	,	,	PUNCT
fnp-4366	31	68	while	while	SCONJ
fnp-4366	31	69	p16	p16	NOUN
fnp-4366	31	70	immunostaining	immunostaining	NOUN
fnp-4366	31	71	represents	represent	VERB
fnp-4366	31	72	a	a	DET
fnp-4366	31	73	good	good	ADJ
fnp-4366	31	74	alternative	alternative	NOUN
fnp-4366	31	75	for	for	ADP
fnp-4366	31	76	detecting	detect	VERB
fnp-4366	31	77	cdkn2a	cdkn2a	PROPN
fnp-4366	31	78	/	/	SYM
fnp-4366	31	79	b	b	PROPN
fnp-4366	31	80	hd	hd	NOUN
fnp-4366	31	81	.	.	PUNCT
fnp-4366	31	82	discovering	discover	VERB
fnp-4366	31	83	cdkn2a	cdkn2a	PROPN
fnp-4366	31	84	/	/	SYM
fnp-4366	31	85	b	b	PROPN
fnp-4366	31	86	hd	hd	PROPN
fnp-4366	31	87	through	through	ADP
fnp-4366	31	88	mtap	mtap	ADJ
fnp-4366	31	89	and/or	and/or	CCONJ
fnp-4366	31	90	p16	p16	NUM
fnp-4366	31	91	immunohistochemistry	immunohistochemistry	NOUN
fnp-4366	31	92	seems	seem	VERB
fnp-4366	31	93	to	to	PART
fnp-4366	31	94	be	be	AUX
fnp-4366	31	95	a	a	DET
fnp-4366	31	96	more	more	ADV
fnp-4366	31	97	accurate	accurate	ADJ
fnp-4366	31	98	method	method	NOUN
fnp-4366	31	99	than	than	ADP
fnp-4366	31	100	the	the	DET
fnp-4366	31	101	cnv	cnv	NOUN
fnp-4366	31	102	analysis	analysis	NOUN
fnp-4366	31	103	derived	derive	VERB
fnp-4366	31	104	from	from	ADP
fnp-4366	31	105	genome	genome	NOUN
fnp-4366	31	106	-	-	PUNCT
fnp-4366	31	107	wide	wide	ADJ
fnp-4366	31	108	dna	dna	PROPN
fnp-4366	31	109	methylation	methylation	NOUN
fnp-4366	31	110	data	datum	NOUN
fnp-4366	31	111	.	.	PUNCT
fnp-4366	31	112	  	  	SPACE
fnp-4366	32	1	1.02	1.02	NUM
fnp-4366	32	2	free	free	ADJ
fnp-4366	32	3	neuropathol	neuropathol	NOUN
fnp-4366	32	4	3:20:6	3:20:6	NUM
fnp-4366	32	5	artificial	artificial	ADJ
fnp-4366	32	6	intelligence	intelligence	NOUN
fnp-4366	32	7	in	in	ADP
fnp-4366	32	8	morphomolecular	morphomolecular	ADJ
fnp-4366	32	9	analysis	analysis	NOUN
fnp-4366	32	10	of	of	ADP
fnp-4366	32	11	glioblastoma	glioblastoma	NOUN
fnp-4366	32	12	stephan	stephan	PROPN
fnp-4366	32	13	balogh1	balogh1	PROPN
fnp-4366	32	14	,	,	PUNCT
fnp-4366	32	15	karen	karen	PROPN
fnp-4366	32	16	brengmann1	brengmann1	PROPN
fnp-4366	32	17	,	,	PUNCT
fnp-4366	32	18	jannik	jannik	PROPN
fnp-4366	32	19	sehring1	sehring1	PROPN
fnp-4366	32	20	,	,	PUNCT
fnp-4366	32	21	thomas	thomas	PROPN
fnp-4366	32	22	kauer1	kauer1	PROPN
fnp-4366	32	23	,	,	PUNCT
fnp-4366	32	24	gudrun	gudrun	PROPN
fnp-4366	32	25	schmidt1	schmidt1	PROPN
fnp-4366	32	26	,	,	PUNCT
fnp-4366	32	27	till	till	SCONJ
fnp-4366	32	28	acker1	acker1	PROPN
fnp-4366	32	29	,	,	PUNCT
fnp-4366	32	30	daniel	daniel	PROPN
fnp-4366	32	31	amsel1	amsel1	PROPN
fnp-4366	32	32	,	,	PUNCT
fnp-4366	32	33	hildegard	hildegard	NOUN
fnp-4366	32	34	dohmen1	dohmen1	ADJ
fnp-4366	32	35	1	1	NUM
fnp-4366	32	36	institute	institute	NOUN
fnp-4366	32	37	of	of	ADP
fnp-4366	32	38	neuropathology	neuropathology	NOUN
fnp-4366	32	39	,	,	PUNCT
fnp-4366	32	40	justus	justus	PROPN
fnp-4366	32	41	liebig	liebig	PROPN
fnp-4366	32	42	university	university	PROPN
fnp-4366	32	43	giessen	giessen	VERB
fnp-4366	32	44	,	,	PUNCT
fnp-4366	32	45	giessen	giessen	VERB
fnp-4366	32	46	,	,	PUNCT
fnp-4366	32	47	deutschland	deutschland	NOUN
fnp-4366	32	48	background	background	NOUN
fnp-4366	32	49	:	:	PUNCT
fnp-4366	32	50	glioblastoma	glioblastoma	NOUN
fnp-4366	32	51	is	be	AUX
fnp-4366	32	52	the	the	DET
fnp-4366	32	53	most	most	ADV
fnp-4366	32	54	common	common	ADJ
fnp-4366	32	55	primary	primary	ADJ
fnp-4366	32	56	malignant	malignant	ADJ
fnp-4366	32	57	brain	brain	NOUN
fnp-4366	32	58	tumor	tumor	NOUN
fnp-4366	32	59	and	and	CCONJ
fnp-4366	32	60	has	have	VERB
fnp-4366	32	61	a	a	DET
fnp-4366	32	62	poor	poor	ADJ
fnp-4366	32	63	prognosis	prognosis	NOUN
fnp-4366	32	64	despite	despite	SCONJ
fnp-4366	32	65	existing	exist	VERB
fnp-4366	32	66	treatment	treatment	NOUN
fnp-4366	32	67	options	option	NOUN
fnp-4366	32	68	.	.	PUNCT
fnp-4366	33	1	it	it	PRON
fnp-4366	33	2	is	be	AUX
fnp-4366	33	3	characterized	characterize	VERB
fnp-4366	33	4	by	by	ADP
fnp-4366	33	5	its	its	PRON
fnp-4366	33	6	inhomogeneous	inhomogeneous	ADJ
fnp-4366	33	7	appearance	appearance	NOUN
fnp-4366	33	8	and	and	CCONJ
fnp-4366	33	9	molecular	molecular	ADJ
fnp-4366	33	10	heterogeneity	heterogeneity	NOUN
fnp-4366	33	11	.	.	PUNCT
fnp-4366	34	1	a	a	DET
fnp-4366	34	2	detailed	detailed	ADJ
fnp-4366	34	3	diagnosis	diagnosis	NOUN
fnp-4366	34	4	is	be	AUX
fnp-4366	34	5	desirable	desirable	ADJ
fnp-4366	34	6	,	,	PUNCT
fnp-4366	34	7	especially	especially	ADV
fnp-4366	34	8	with	with	ADP
fnp-4366	34	9	regard	regard	NOUN
fnp-4366	34	10	to	to	ADP
fnp-4366	34	11	the	the	DET
fnp-4366	34	12	emerging	emerge	VERB
fnp-4366	34	13	personalized	personalize	VERB
fnp-4366	34	14	medicine	medicine	NOUN
fnp-4366	34	15	to	to	PART
fnp-4366	34	16	guide	guide	VERB
fnp-4366	34	17	treatment	treatment	NOUN
fnp-4366	34	18	decisions	decision	NOUN
fnp-4366	34	19	.	.	PUNCT
fnp-4366	35	1	the	the	DET
fnp-4366	35	2	increasing	increase	VERB
fnp-4366	35	3	application	application	NOUN
fnp-4366	35	4	of	of	ADP
fnp-4366	35	5	whole	whole	ADJ
fnp-4366	35	6	slide	slide	NOUN
fnp-4366	35	7	image	image	NOUN
fnp-4366	35	8	scanners	scanner	NOUN
fnp-4366	35	9	enables	enable	VERB
fnp-4366	35	10	the	the	DET
fnp-4366	35	11	digitalization	digitalization	NOUN
fnp-4366	35	12	of	of	ADP
fnp-4366	35	13	histopathological	histopathological	ADJ
fnp-4366	35	14	slides	slide	NOUN
fnp-4366	35	15	,	,	PUNCT
fnp-4366	35	16	collected	collect	VERB
fnp-4366	35	17	in	in	ADP
fnp-4366	35	18	clinical	clinical	ADJ
fnp-4366	35	19	routine	routine	ADJ
fnp-4366	35	20	diagnostics	diagnostic	NOUN
fnp-4366	35	21	,	,	PUNCT
fnp-4366	35	22	into	into	ADP
fnp-4366	35	23	high	high	ADJ
fnp-4366	35	24	-	-	PUNCT
fnp-4366	35	25	quality	quality	NOUN
fnp-4366	35	26	images	image	NOUN
fnp-4366	35	27	that	that	PRON
fnp-4366	35	28	offer	offer	VERB
fnp-4366	35	29	new	new	ADJ
fnp-4366	35	30	possibilities	possibility	NOUN
fnp-4366	35	31	for	for	ADP
fnp-4366	35	32	computer	computer	NOUN
fnp-4366	35	33	-	-	PUNCT
fnp-4366	35	34	aided	aid	VERB
fnp-4366	35	35	precision	precision	NOUN
fnp-4366	35	36	diagnostics	diagnostic	NOUN
fnp-4366	35	37	.	.	PUNCT
fnp-4366	36	1	objective	objective	NOUN
fnp-4366	36	2	:	:	PUNCT
fnp-4366	36	3	the	the	DET
fnp-4366	36	4	goal	goal	NOUN
fnp-4366	36	5	of	of	ADP
fnp-4366	36	6	our	our	PRON
fnp-4366	36	7	work	work	NOUN
fnp-4366	36	8	-	-	PUNCT
fnp-4366	36	9	in	in	ADP
fnp-4366	36	10	-	-	PUNCT
fnp-4366	36	11	progress	progress	NOUN
fnp-4366	36	12	project	project	NOUN
fnp-4366	36	13	is	be	AUX
fnp-4366	36	14	to	to	PART
fnp-4366	36	15	curate	curate	VERB
fnp-4366	36	16	a	a	DET
fnp-4366	36	17	high	high	ADJ
fnp-4366	36	18	-	-	PUNCT
fnp-4366	36	19	resolution	resolution	NOUN
fnp-4366	36	20	dataset	dataset	NOUN
fnp-4366	36	21	with	with	ADP
fnp-4366	36	22	annotations	annotation	NOUN
fnp-4366	36	23	to	to	PART
fnp-4366	36	24	train	train	VERB
fnp-4366	36	25	an	an	DET
fnp-4366	36	26	artificial	artificial	ADJ
fnp-4366	36	27	intelligence	intelligence	NOUN
fnp-4366	36	28	to	to	PART
fnp-4366	36	29	independently	independently	ADV
fnp-4366	36	30	recognize	recognize	VERB
fnp-4366	36	31	characteristic	characteristic	ADJ
fnp-4366	36	32	structures	structure	NOUN
fnp-4366	36	33	of	of	ADP
fnp-4366	36	34	glioblastoma	glioblastoma	NOUN
fnp-4366	36	35	tissue	tissue	NOUN
fnp-4366	36	36	sections	section	NOUN
fnp-4366	36	37	,	,	PUNCT
fnp-4366	36	38	such	such	ADJ
fnp-4366	36	39	as	as	ADP
fnp-4366	36	40	tumor	tumor	NOUN
fnp-4366	36	41	area	area	NOUN
fnp-4366	36	42	,	,	PUNCT
fnp-4366	36	43	vascular	vascular	ADJ
fnp-4366	36	44	proliferation	proliferation	NOUN
fnp-4366	36	45	and	and	CCONJ
fnp-4366	36	46	necrosis	necrosis	NOUN
fnp-4366	36	47	.	.	PUNCT
fnp-4366	37	1	using	use	VERB
fnp-4366	37	2	these	these	DET
fnp-4366	37	3	ai	ai	NOUN
fnp-4366	37	4	-	-	PUNCT
fnp-4366	37	5	based	base	VERB
fnp-4366	37	6	algorithms	algorithm	NOUN
fnp-4366	37	7	,	,	PUNCT
fnp-4366	37	8	we	we	PRON
fnp-4366	37	9	aim	aim	VERB
fnp-4366	37	10	to	to	PART
fnp-4366	37	11	gain	gain	VERB
fnp-4366	37	12	new	new	ADJ
fnp-4366	37	13	insights	insight	NOUN
fnp-4366	37	14	that	that	PRON
fnp-4366	37	15	could	could	AUX
fnp-4366	37	16	help	help	VERB
fnp-4366	37	17	refine	refine	VERB
fnp-4366	37	18	the	the	DET
fnp-4366	37	19	characterization	characterization	NOUN
fnp-4366	37	20	of	of	ADP
fnp-4366	37	21	glioblastomas	glioblastoma	NOUN
fnp-4366	37	22	by	by	ADP
fnp-4366	37	23	correlating	correlate	VERB
fnp-4366	37	24	morphological	morphological	ADJ
fnp-4366	37	25	information	information	NOUN
fnp-4366	37	26	with	with	ADP
fnp-4366	37	27	available	available	ADJ
fnp-4366	37	28	clinical	clinical	ADJ
fnp-4366	37	29	and	and	CCONJ
fnp-4366	37	30	molecular	molecular	ADJ
fnp-4366	37	31	data	datum	NOUN
fnp-4366	37	32	.	.	PUNCT
fnp-4366	38	1	methods	method	NOUN
fnp-4366	38	2	:	:	PUNCT
fnp-4366	38	3	initially	initially	ADV
fnp-4366	38	4	,	,	PUNCT
fnp-4366	38	5	clinical	clinical	ADJ
fnp-4366	38	6	and	and	CCONJ
fnp-4366	38	7	molecular	molecular	ADJ
fnp-4366	38	8	information	information	NOUN
fnp-4366	38	9	on	on	ADP
fnp-4366	38	10	200	200	NUM
fnp-4366	38	11	glioblastoma	glioblastoma	NOUN
fnp-4366	38	12	patients	patient	NOUN
fnp-4366	38	13	was	be	AUX
fnp-4366	38	14	gathered	gather	VERB
fnp-4366	38	15	.	.	PUNCT
fnp-4366	39	1	the	the	DET
fnp-4366	39	2	corresponding	corresponding	ADJ
fnp-4366	39	3	hematoxylin	hematoxylin	NOUN
fnp-4366	39	4	-	-	PUNCT
fnp-4366	39	5	eosin	eosin	NOUN
fnp-4366	39	6	-	-	PUNCT
fnp-4366	39	7	stained	stain	VERB
fnp-4366	39	8	histopathological	histopathological	ADJ
fnp-4366	39	9	slides	slide	NOUN
fnp-4366	39	10	were	be	AUX
fnp-4366	39	11	then	then	ADV
fnp-4366	39	12	digitized	digitize	VERB
fnp-4366	39	13	using	use	VERB
fnp-4366	39	14	a	a	DET
fnp-4366	39	15	high	high	ADJ
fnp-4366	39	16	-	-	PUNCT
fnp-4366	39	17	throughput	throughput	NOUN
fnp-4366	39	18	whole	whole	ADJ
fnp-4366	39	19	slide	slide	NOUN
fnp-4366	39	20	image	image	NOUN
fnp-4366	39	21	scanner	scanner	NOUN
fnp-4366	39	22	(	(	PUNCT
fnp-4366	39	23	hamamatsu	hamamatsu	NOUN
fnp-4366	39	24	nanozoomer	nanozoomer	NOUN
fnp-4366	39	25	s360	s360	PROPN
fnp-4366	39	26	)	)	PUNCT
fnp-4366	39	27	.	.	PUNCT
fnp-4366	40	1	the	the	DET
fnp-4366	40	2	annotation	annotation	NOUN
fnp-4366	40	3	of	of	ADP
fnp-4366	40	4	key	key	ADJ
fnp-4366	40	5	features	feature	NOUN
fnp-4366	40	6	in	in	ADP
fnp-4366	40	7	the	the	DET
fnp-4366	40	8	images	image	NOUN
fnp-4366	40	9	was	be	AUX
fnp-4366	40	10	divided	divide	VERB
fnp-4366	40	11	into	into	ADP
fnp-4366	40	12	two	two	NUM
fnp-4366	40	13	distinct	distinct	ADJ
fnp-4366	40	14	phases	phase	NOUN
fnp-4366	40	15	.	.	PUNCT
fnp-4366	41	1	prior	prior	ADV
fnp-4366	41	2	to	to	ADP
fnp-4366	41	3	the	the	DET
fnp-4366	41	4	actual	actual	ADJ
fnp-4366	41	5	annotation	annotation	NOUN
fnp-4366	41	6	phase	phase	NOUN
fnp-4366	41	7	,	,	PUNCT
fnp-4366	41	8	two	two	NUM
fnp-4366	41	9	md	md	PROPN
fnp-4366	41	10	students	student	NOUN
fnp-4366	41	11	completed	complete	VERB
fnp-4366	41	12	a	a	DET
fnp-4366	41	13	training	training	NOUN
fnp-4366	41	14	phase	phase	NOUN
fnp-4366	41	15	with	with	ADP
fnp-4366	41	16	a	a	DET
fnp-4366	41	17	small	small	ADJ
fnp-4366	41	18	batch	batch	NOUN
fnp-4366	41	19	of	of	ADP
fnp-4366	41	20	images	image	NOUN
fnp-4366	41	21	(	(	PUNCT
fnp-4366	41	22	n=10	n=10	NOUN
fnp-4366	41	23	)	)	PUNCT
fnp-4366	41	24	in	in	ADP
fnp-4366	41	25	order	order	NOUN
fnp-4366	41	26	to	to	PART
fnp-4366	41	27	get	get	VERB
fnp-4366	41	28	hands	hand	NOUN
fnp-4366	41	29	-	-	PUNCT
fnp-4366	41	30	on	on	ADP
fnp-4366	41	31	experience	experience	NOUN
fnp-4366	41	32	with	with	ADP
fnp-4366	41	33	the	the	DET
fnp-4366	41	34	annotation	annotation	NOUN
fnp-4366	41	35	software	software	NOUN
fnp-4366	41	36	and	and	CCONJ
fnp-4366	41	37	difficult	difficult	ADJ
fnp-4366	41	38	issues	issue	NOUN
fnp-4366	41	39	(	(	PUNCT
fnp-4366	41	40	qupath	qupath	NOUN
fnp-4366	41	41	version	version	NOUN
fnp-4366	41	42	0.3.0	0.3.0	NOUN
fnp-4366	41	43	)	)	PUNCT
fnp-4366	41	44	.	.	PUNCT
fnp-4366	42	1	the	the	DET
fnp-4366	42	2	ground	ground	NOUN
fnp-4366	42	3	truth	truth	NOUN
fnp-4366	42	4	was	be	AUX
fnp-4366	42	5	determined	determine	VERB
fnp-4366	42	6	by	by	ADP
fnp-4366	42	7	an	an	DET
fnp-4366	42	8	experienced	experienced	ADJ
fnp-4366	42	9	neuropathologist	neuropathologist	NOUN
fnp-4366	42	10	.	.	PUNCT
fnp-4366	43	1	evaluation	evaluation	NOUN
fnp-4366	43	2	:	:	PUNCT
fnp-4366	43	3	the	the	DET
fnp-4366	43	4	interand	interand	NOUN
fnp-4366	43	5	intraobserver	intraobserver	NOUN
fnp-4366	43	6	variability	variability	NOUN
fnp-4366	43	7	of	of	ADP
fnp-4366	43	8	the	the	DET
fnp-4366	43	9	two	two	NUM
fnp-4366	43	10	students	student	NOUN
fnp-4366	43	11	will	will	AUX
fnp-4366	43	12	be	be	AUX
fnp-4366	43	13	evaluated	evaluate	VERB
fnp-4366	43	14	with	with	ADP
fnp-4366	43	15	regard	regard	NOUN
fnp-4366	43	16	to	to	ADP
fnp-4366	43	17	the	the	DET
fnp-4366	43	18	learning	learn	VERB
fnp-4366	43	19	progress	progress	NOUN
fnp-4366	43	20	(	(	PUNCT
fnp-4366	43	21	e.g.	e.g.	ADV
fnp-4366	43	22	accuracy	accuracy	NOUN
fnp-4366	43	23	,	,	PUNCT
fnp-4366	43	24	classification	classification	NOUN
fnp-4366	43	25	of	of	ADP
fnp-4366	43	26	a	a	DET
fnp-4366	43	27	tissue	tissue	NOUN
fnp-4366	43	28	area	area	NOUN
fnp-4366	43	29	)	)	PUNCT
fnp-4366	43	30	and	and	CCONJ
fnp-4366	43	31	differences	difference	NOUN
fnp-4366	43	32	between	between	ADP
fnp-4366	43	33	the	the	DET
fnp-4366	43	34	annotations	annotation	NOUN
fnp-4366	43	35	of	of	ADP
fnp-4366	43	36	the	the	DET
fnp-4366	43	37	two	two	NUM
fnp-4366	43	38	students	student	NOUN
fnp-4366	43	39	,	,	PUNCT
fnp-4366	43	40	derived	derive	VERB
fnp-4366	43	41	from	from	ADP
fnp-4366	43	42	subjective	subjective	ADJ
fnp-4366	43	43	assessment	assessment	NOUN
fnp-4366	43	44	.	.	PUNCT
fnp-4366	44	1	in	in	ADP
fnp-4366	44	2	the	the	DET
fnp-4366	44	3	second	second	ADJ
fnp-4366	44	4	part	part	NOUN
fnp-4366	44	5	,	,	PUNCT
fnp-4366	44	6	correlations	correlation	NOUN
fnp-4366	44	7	between	between	ADP
fnp-4366	44	8	morphological	morphological	ADJ
fnp-4366	44	9	information	information	NOUN
fnp-4366	44	10	(	(	PUNCT
fnp-4366	44	11	vascular	vascular	ADJ
fnp-4366	44	12	proliferation	proliferation	NOUN
fnp-4366	44	13	and	and	CCONJ
fnp-4366	44	14	necrosis	necrosis	NOUN
fnp-4366	44	15	with	with	ADP
fnp-4366	44	16	pseudopalisading	pseudopalisade	VERB
fnp-4366	44	17	)	)	PUNCT
fnp-4366	44	18	and	and	CCONJ
fnp-4366	44	19	clinical	clinical	ADJ
fnp-4366	44	20	and	and	CCONJ
fnp-4366	44	21	molecular	molecular	ADJ
fnp-4366	44	22	information	information	NOUN
fnp-4366	44	23	will	will	AUX
fnp-4366	44	24	be	be	AUX
fnp-4366	44	25	examined	examine	VERB
fnp-4366	44	26	.	.	PUNCT
fnp-4366	45	1	these	these	DET
fnp-4366	45	2	annotated	annotate	VERB
fnp-4366	45	3	slides	slide	NOUN
fnp-4366	45	4	will	will	AUX
fnp-4366	45	5	serve	serve	VERB
fnp-4366	45	6	as	as	ADP
fnp-4366	45	7	training	training	NOUN
fnp-4366	45	8	and	and	CCONJ
fnp-4366	45	9	test	test	NOUN
fnp-4366	45	10	sets	set	NOUN
fnp-4366	45	11	for	for	ADP
fnp-4366	45	12	in	in	ADP
fnp-4366	45	13	-	-	PUNCT
fnp-4366	45	14	house	house	NOUN
fnp-4366	45	15	ai	ai	NOUN
fnp-4366	45	16	-	-	PUNCT
fnp-4366	45	17	based	base	VERB
fnp-4366	45	18	predictions	prediction	NOUN
fnp-4366	45	19	.	.	PUNCT
fnp-4366	46	1	perspective	perspective	NOUN
fnp-4366	46	2	:	:	PUNCT
fnp-4366	46	3	our	our	PRON
fnp-4366	46	4	data	datum	NOUN
fnp-4366	46	5	will	will	AUX
fnp-4366	46	6	be	be	AUX
fnp-4366	46	7	used	use	VERB
fnp-4366	46	8	as	as	ADP
fnp-4366	46	9	a	a	DET
fnp-4366	46	10	resource	resource	NOUN
fnp-4366	46	11	for	for	ADP
fnp-4366	46	12	an	an	DET
fnp-4366	46	13	in	in	ADP
fnp-4366	46	14	-	-	PUNCT
fnp-4366	46	15	house	house	NOUN
fnp-4366	46	16	developed	develop	VERB
fnp-4366	46	17	app	app	NOUN
fnp-4366	46	18	that	that	PRON
fnp-4366	46	19	will	will	AUX
fnp-4366	46	20	serve	serve	VERB
fnp-4366	46	21	as	as	ADP
fnp-4366	46	22	a	a	DET
fnp-4366	46	23	learning	learning	NOUN
fnp-4366	46	24	solution	solution	NOUN
fnp-4366	46	25	for	for	ADP
fnp-4366	46	26	medical	medical	ADJ
fnp-4366	46	27	students	student	NOUN
fnp-4366	46	28	,	,	PUNCT
fnp-4366	46	29	but	but	CCONJ
fnp-4366	46	30	also	also	ADV
fnp-4366	46	31	as	as	ADP
fnp-4366	46	32	a	a	DET
fnp-4366	46	33	crowdsourcing	crowdsourcing	NOUN
fnp-4366	46	34	platform	platform	NOUN
fnp-4366	46	35	for	for	ADP
fnp-4366	46	36	the	the	DET
fnp-4366	46	37	annotation	annotation	NOUN
fnp-4366	46	38	of	of	ADP
fnp-4366	46	39	features	feature	NOUN
fnp-4366	46	40	on	on	ADP
fnp-4366	46	41	small	small	ADJ
fnp-4366	46	42	patches	patch	NOUN
fnp-4366	46	43	of	of	ADP
fnp-4366	46	44	whole	whole	ADJ
fnp-4366	46	45	slide	slide	NOUN
fnp-4366	46	46	images	image	NOUN
fnp-4366	46	47	.	.	PUNCT
fnp-4366	47	1	in	in	ADP
fnp-4366	47	2	addition	addition	NOUN
fnp-4366	47	3	,	,	PUNCT
fnp-4366	47	4	the	the	DET
fnp-4366	47	5	curated	curate	VERB
fnp-4366	47	6	high	high	ADJ
fnp-4366	47	7	-	-	PUNCT
fnp-4366	47	8	resolution	resolution	NOUN
fnp-4366	47	9	data	datum	NOUN
fnp-4366	47	10	set	set	NOUN
fnp-4366	47	11	will	will	AUX
fnp-4366	47	12	serve	serve	VERB
fnp-4366	47	13	as	as	ADP
fnp-4366	47	14	input	input	NOUN
fnp-4366	47	15	for	for	ADP
fnp-4366	47	16	further	far	ADV
fnp-4366	47	17	internally	internally	ADV
fnp-4366	47	18	developed	develop	VERB
fnp-4366	47	19	ai	ai	VERB
fnp-4366	47	20	algorithms	algorithm	NOUN
fnp-4366	47	21	to	to	PART
fnp-4366	47	22	support	support	VERB
fnp-4366	47	23	tumor	tumor	NOUN
fnp-4366	47	24	diagnosis	diagnosis	NOUN
fnp-4366	47	25	and	and	CCONJ
fnp-4366	47	26	therapy	therapy	NOUN
fnp-4366	47	27	decisions	decision	NOUN
fnp-4366	47	28	.	.	PUNCT
fnp-4366	47	29	  	  	SPACE
fnp-4366	48	1	1.03	1.03	NUM
fnp-4366	48	2	free	free	ADJ
fnp-4366	48	3	neuropathol	neuropathol	NOUN
fnp-4366	48	4	3:20:7	3:20:7	NUM
fnp-4366	48	5	histological	histological	ADJ
fnp-4366	48	6	and	and	CCONJ
fnp-4366	48	7	molecular	molecular	ADJ
fnp-4366	48	8	correlates	correlate	NOUN
fnp-4366	48	9	of	of	ADP
fnp-4366	48	10	tspo	tspo	NOUN
fnp-4366	48	11	labelling	labelling	NOUN
fnp-4366	48	12	in	in	ADP
fnp-4366	48	13	human	human	ADJ
fnp-4366	48	14	brain	brain	NOUN
fnp-4366	48	15	tissue	tissue	NOUN
fnp-4366	48	16	lorraine	lorraine	NOUN
fnp-4366	48	17	weidner1,2	weidner1,2	PROPN
fnp-4366	48	18	,	,	PUNCT
fnp-4366	48	19	franziska	franziska	PROPN
fnp-4366	48	20	dekorsy3	dekorsy3	PROPN
fnp-4366	48	21	,	,	PUNCT
fnp-4366	48	22	stefanie	stefanie	PROPN
fnp-4366	48	23	quach4	quach4	PROPN
fnp-4366	48	24	,	,	PUNCT
fnp-4366	48	25	viktoria	viktoria	PROPN
fnp-4366	48	26	ruf5	ruf5	PROPN
fnp-4366	48	27	,	,	PUNCT
fnp-4366	48	28	julia	julia	PROPN
fnp-4366	48	29	lorenz1,2	lorenz1,2	PROPN
fnp-4366	48	30	,	,	PUNCT
fnp-4366	48	31	peter	peter	PROPN
fnp-4366	48	32	hau2,6	hau2,6	PROPN
fnp-4366	48	33	,	,	PUNCT
fnp-4366	48	34	jörg	jörg	PROPN
fnp-4366	48	35	-	-	PUNCT
fnp-4366	48	36	christian	christian	PROPN
fnp-4366	48	37	tonn4,5	tonn4,5	PROPN
fnp-4366	48	38	,	,	PUNCT
fnp-4366	48	39	peter	peter	PROPN
fnp-4366	48	40	bartenstein3,7	bartenstein3,7	PROPN
fnp-4366	48	41	,	,	PUNCT
fnp-4366	48	42	matthias	matthias	PROPN
fnp-4366	48	43	brendel3,7	brendel3,7	PROPN
fnp-4366	48	44	,	,	PUNCT
fnp-4366	48	45	nathalie	nathalie	PROPN
fnp-4366	48	46	l.	l.	PROPN
fnp-4366	48	47	albert3,7	albert3,7	PROPN
fnp-4366	48	48	,	,	PUNCT
fnp-4366	48	49	markus	markus	PROPN
fnp-4366	48	50	j.	j.	PROPN
fnp-4366	48	51	riemenschneider1,2	riemenschneider1,2	PROPN
fnp-4366	48	52	1	1	NUM
fnp-4366	48	53	regensburg	regensburg	PROPN
fnp-4366	48	54	university	university	NOUN
fnp-4366	48	55	hospital	hospital	NOUN
fnp-4366	48	56	,	,	PUNCT
fnp-4366	48	57	department	department	NOUN
fnp-4366	48	58	of	of	ADP
fnp-4366	48	59	neuropathology	neuropathology	NOUN
fnp-4366	48	60	,	,	PUNCT
fnp-4366	48	61	regensburg	regensburg	PROPN
fnp-4366	48	62	,	,	PUNCT
fnp-4366	48	63	deutschland	deutschland	NOUN
fnp-4366	48	64	2	2	NUM
fnp-4366	48	65	regensburg	regensburg	PROPN
fnp-4366	48	66	university	university	NOUN
fnp-4366	48	67	hospital	hospital	NOUN
fnp-4366	48	68	,	,	PUNCT
fnp-4366	48	69	wilhelm	wilhelm	PROPN
fnp-4366	48	70	sander	sander	PROPN
fnp-4366	48	71	neuro	neuro	PROPN
fnp-4366	48	72	-	-	PUNCT
fnp-4366	48	73	oncology	oncology	NOUN
fnp-4366	48	74	unit	unit	NOUN
fnp-4366	48	75	,	,	PUNCT
fnp-4366	48	76	regensburg	regensburg	PROPN
fnp-4366	48	77	,	,	PUNCT
fnp-4366	48	78	deutschland	deutschland	NOUN
fnp-4366	48	79	3	3	NUM
fnp-4366	48	80	university	university	NOUN
fnp-4366	48	81	hospital	hospital	NOUN
fnp-4366	48	82	of	of	ADP
fnp-4366	48	83	munich	munich	PROPN
fnp-4366	48	84	,	,	PUNCT
fnp-4366	48	85	lmu	lmu	PROPN
fnp-4366	48	86	munich	munich	PROPN
fnp-4366	48	87	,	,	PUNCT
fnp-4366	48	88	department	department	NOUN
fnp-4366	48	89	of	of	ADP
fnp-4366	48	90	nuclear	nuclear	ADJ
fnp-4366	48	91	medicine	medicine	NOUN
fnp-4366	48	92	,	,	PUNCT
fnp-4366	48	93	münchen	münchen	NOUN
fnp-4366	48	94	,	,	PUNCT
fnp-4366	48	95	deutschland	deutschland	NOUN
fnp-4366	48	96	4	4	NUM
fnp-4366	48	97	university	university	NOUN
fnp-4366	48	98	hospital	hospital	NOUN
fnp-4366	48	99	of	of	ADP
fnp-4366	48	100	munich	munich	PROPN
fnp-4366	48	101	,	,	PUNCT
fnp-4366	48	102	lmu	lmu	PROPN
fnp-4366	48	103	munich	munich	PROPN
fnp-4366	48	104	,	,	PUNCT
fnp-4366	48	105	department	department	NOUN
fnp-4366	48	106	of	of	ADP
fnp-4366	48	107	neurosurgery	neurosurgery	NOUN
fnp-4366	48	108	,	,	PUNCT
fnp-4366	48	109	münchen	münchen	NOUN
fnp-4366	48	110	,	,	PUNCT
fnp-4366	48	111	deutschland	deutschland	NOUN
fnp-4366	48	112	5	5	NUM
fnp-4366	48	113	lmu	lmu	PROPN
fnp-4366	48	114	munich	munich	PROPN
fnp-4366	48	115	,	,	PUNCT
fnp-4366	48	116	center	center	NOUN
fnp-4366	48	117	for	for	ADP
fnp-4366	48	118	neuropathology	neuropathology	NOUN
fnp-4366	48	119	and	and	CCONJ
fnp-4366	48	120	prion	prion	NOUN
fnp-4366	48	121	research	research	NOUN
fnp-4366	48	122	,	,	PUNCT
fnp-4366	48	123	münchen	münchen	NOUN
fnp-4366	48	124	,	,	PUNCT
fnp-4366	48	125	deutschland	deutschland	NOUN
fnp-4366	48	126	6	6	NUM
fnp-4366	48	127	regensburg	regensburg	PROPN
fnp-4366	48	128	university	university	NOUN
fnp-4366	48	129	hospital	hospital	NOUN
fnp-4366	48	130	,	,	PUNCT
fnp-4366	48	131	department	department	NOUN
fnp-4366	48	132	of	of	ADP
fnp-4366	48	133	neurology	neurology	NOUN
fnp-4366	48	134	,	,	PUNCT
fnp-4366	48	135	regensburg	regensburg	PROPN
fnp-4366	48	136	,	,	PUNCT
fnp-4366	48	137	deutschland	deutschland	NOUN
fnp-4366	48	138	7	7	NUM
fnp-4366	48	139	german	german	ADJ
fnp-4366	48	140	cancer	cancer	NOUN
fnp-4366	48	141	research	research	NOUN
fnp-4366	48	142	center	center	NOUN
fnp-4366	48	143	(	(	PUNCT
fnp-4366	48	144	dkfz	dkfz	NOUN
fnp-4366	48	145	)	)	PUNCT
fnp-4366	48	146	,	,	PUNCT
fnp-4366	48	147	german	german	ADJ
fnp-4366	48	148	cancer	cancer	NOUN
fnp-4366	48	149	consortium	consortium	NOUN
fnp-4366	48	150	(	(	PUNCT
fnp-4366	48	151	dktk	dktk	NOUN
fnp-4366	48	152	)	)	PUNCT
fnp-4366	48	153	,	,	PUNCT
fnp-4366	48	154	partner	partner	NOUN
fnp-4366	48	155	site	site	PROPN
fnp-4366	48	156	munich	munich	PROPN
fnp-4366	48	157	,	,	PUNCT
fnp-4366	48	158	heidelberg	heidelberg	PROPN
fnp-4366	48	159	,	,	PUNCT
fnp-4366	48	160	deutschland	deutschland	NOUN
fnp-4366	48	161	background	background	NOUN
fnp-4366	48	162	:	:	PUNCT
fnp-4366	48	163	tspo	tspo	PROPN
fnp-4366	48	164	is	be	AUX
fnp-4366	48	165	frequently	frequently	ADV
fnp-4366	48	166	upregulated	upregulate	VERB
fnp-4366	48	167	in	in	ADP
fnp-4366	48	168	neoplastically	neoplastically	ADV
fnp-4366	48	169	transformed	transform	VERB
fnp-4366	48	170	tissues	tissue	NOUN
fnp-4366	48	171	,	,	PUNCT
fnp-4366	48	172	including	include	VERB
fnp-4366	48	173	glioblastomas	glioblastoma	NOUN
fnp-4366	48	174	.	.	PUNCT
fnp-4366	49	1	this	this	PRON
fnp-4366	49	2	may	may	AUX
fnp-4366	49	3	be	be	AUX
fnp-4366	49	4	of	of	ADP
fnp-4366	49	5	use	use	NOUN
fnp-4366	49	6	for	for	ADP
fnp-4366	49	7	pet	pet	ADJ
fnp-4366	49	8	imaging	imaging	NOUN
fnp-4366	49	9	of	of	ADP
fnp-4366	49	10	brain	brain	NOUN
fnp-4366	49	11	tumors	tumor	NOUN
fnp-4366	49	12	.	.	PUNCT
fnp-4366	50	1	however	however	ADV
fnp-4366	50	2	,	,	PUNCT
fnp-4366	50	3	due	due	ADP
fnp-4366	50	4	to	to	ADP
fnp-4366	50	5	the	the	DET
fnp-4366	50	6	heterogeneity	heterogeneity	NOUN
fnp-4366	50	7	of	of	ADP
fnp-4366	50	8	cell	cell	NOUN
fnp-4366	50	9	populations	population	NOUN
fnp-4366	50	10	that	that	PRON
fnp-4366	50	11	could	could	AUX
fnp-4366	50	12	contribute	contribute	VERB
fnp-4366	50	13	as	as	ADP
fnp-4366	50	14	tspo	tspo	NOUN
fnp-4366	50	15	-	-	PUNCT
fnp-4366	50	16	pet	pet	NOUN
fnp-4366	50	17	signal	signal	NOUN
fnp-4366	50	18	source	source	NOUN
fnp-4366	50	19	in	in	ADP
fnp-4366	50	20	gliomas	glioma	NOUN
fnp-4366	50	21	,	,	PUNCT
fnp-4366	50	22	the	the	DET
fnp-4366	50	23	imaging	imaging	NOUN
fnp-4366	50	24	biomarker	biomarker	NOUN
fnp-4366	50	25	interpretation	interpretation	NOUN
fnp-4366	50	26	may	may	AUX
fnp-4366	50	27	be	be	AUX
fnp-4366	50	28	challenging	challenging	ADJ
fnp-4366	50	29	.	.	PUNCT
fnp-4366	51	1	aim	aim	NOUN
fnp-4366	51	2	:	:	PUNCT
fnp-4366	51	3	we	we	PRON
fnp-4366	51	4	therefore	therefore	ADV
fnp-4366	51	5	dissect	dissect	VERB
fnp-4366	51	6	tspo	tspo	NOUN
fnp-4366	51	7	labelling	labelling	NOUN
fnp-4366	51	8	in	in	ADP
fnp-4366	51	9	connection	connection	NOUN
fnp-4366	51	10	with	with	ADP
fnp-4366	51	11	the	the	DET
fnp-4366	51	12	underlying	underlie	VERB
fnp-4366	51	13	histopathological	histopathological	ADJ
fnp-4366	51	14	and	and	CCONJ
fnp-4366	51	15	molecular	molecular	ADJ
fnp-4366	51	16	features	feature	NOUN
fnp-4366	51	17	in	in	ADP
fnp-4366	51	18	biopsy	biopsy	NOUN
fnp-4366	51	19	samples	sample	NOUN
fnp-4366	51	20	from	from	ADP
fnp-4366	51	21	glioma	glioma	ADJ
fnp-4366	51	22	patients	patient	NOUN
fnp-4366	51	23	.	.	PUNCT
fnp-4366	52	1	question	question	NOUN
fnp-4366	52	2	:	:	PUNCT
fnp-4366	52	3	to	to	PART
fnp-4366	52	4	decipher	decipher	VERB
fnp-4366	52	5	the	the	DET
fnp-4366	52	6	underlying	underlying	ADJ
fnp-4366	52	7	histopathological	histopathological	ADJ
fnp-4366	52	8	and	and	CCONJ
fnp-4366	52	9	molecular	molecular	ADJ
fnp-4366	52	10	features	feature	NOUN
fnp-4366	52	11	of	of	ADP
fnp-4366	52	12	tspo	tspo	NOUN
fnp-4366	52	13	-	-	PUNCT
fnp-4366	52	14	pet	pet	NOUN
fnp-4366	52	15	enrichment	enrichment	NOUN
fnp-4366	52	16	.	.	PUNCT
fnp-4366	53	1	methods	method	NOUN
fnp-4366	53	2	:	:	PUNCT
fnp-4366	53	3	we	we	PRON
fnp-4366	53	4	aim	aim	VERB
fnp-4366	53	5	to	to	PART
fnp-4366	53	6	collect	collect	VERB
fnp-4366	53	7	a	a	DET
fnp-4366	53	8	total	total	NOUN
fnp-4366	53	9	of	of	ADP
fnp-4366	53	10	75	75	NUM
fnp-4366	53	11	glioma	glioma	NOUN
fnp-4366	53	12	patients	patient	NOUN
fnp-4366	53	13	all	all	PRON
fnp-4366	53	14	characterized	characterize	VERB
fnp-4366	53	15	by	by	ADP
fnp-4366	53	16	mri	mri	NOUN
fnp-4366	53	17	,	,	PUNCT
fnp-4366	53	18	tspoand	tspoand	PROPN
fnp-4366	53	19	fet	fet	PROPN
fnp-4366	53	20	-	-	PROPN
fnp-4366	53	21	pet	pet	PROPN
fnp-4366	53	22	.	.	PUNCT
fnp-4366	54	1	tspo	tspo	NOUN
fnp-4366	54	2	protein	protein	NOUN
fnp-4366	54	3	expression	expression	NOUN
fnp-4366	54	4	and	and	CCONJ
fnp-4366	54	5	expression	expression	NOUN
fnp-4366	54	6	of	of	ADP
fnp-4366	54	7	cell	cell	NOUN
fnp-4366	54	8	differentiation	differentiation	NOUN
fnp-4366	54	9	markers	marker	NOUN
fnp-4366	54	10	are	be	AUX
fnp-4366	54	11	assessed	assess	VERB
fnp-4366	54	12	immunohistochemically	immunohistochemically	ADV
fnp-4366	54	13	on	on	ADP
fnp-4366	54	14	consecutive	consecutive	ADJ
fnp-4366	54	15	sections	section	NOUN
fnp-4366	54	16	and	and	CCONJ
fnp-4366	54	17	by	by	ADP
fnp-4366	54	18	multiplex	multiplex	PROPN
fnp-4366	54	19	stains	stain	NOUN
fnp-4366	54	20	.	.	PUNCT
fnp-4366	55	1	rna	rna	NOUN
fnp-4366	55	2	isolation	isolation	NOUN
fnp-4366	55	3	has	have	AUX
fnp-4366	55	4	been	be	AUX
fnp-4366	55	5	optimized	optimize	VERB
fnp-4366	55	6	to	to	PART
fnp-4366	55	7	perform	perform	VERB
fnp-4366	55	8	rna	rna	NOUN
fnp-4366	55	9	-	-	PUNCT
fnp-4366	55	10	seq	seq	NOUN
fnp-4366	55	11	on	on	ADP
fnp-4366	55	12	biopsy	biopsy	NOUN
fnp-4366	55	13	samples	sample	NOUN
fnp-4366	55	14	and	and	CCONJ
fnp-4366	55	15	to	to	PART
fnp-4366	55	16	compare	compare	VERB
fnp-4366	55	17	regions	region	NOUN
fnp-4366	55	18	of	of	ADP
fnp-4366	55	19	high	high	ADJ
fnp-4366	55	20	and	and	CCONJ
fnp-4366	55	21	low	low	ADJ
fnp-4366	55	22	tspo	tspo	NOUN
fnp-4366	55	23	-	-	PUNCT
fnp-4366	55	24	pet	pet	NOUN
fnp-4366	55	25	signal	signal	NOUN
fnp-4366	55	26	/	/	SYM
fnp-4366	55	27	protein	protein	NOUN
fnp-4366	55	28	expression	expression	NOUN
fnp-4366	55	29	.	.	PUNCT
fnp-4366	56	1	to	to	PART
fnp-4366	56	2	identify	identify	VERB
fnp-4366	56	3	relevant	relevant	ADJ
fnp-4366	56	4	hallmarks	hallmark	NOUN
fnp-4366	56	5	and	and	CCONJ
fnp-4366	56	6	go	go	VERB
fnp-4366	56	7	terms	term	NOUN
fnp-4366	56	8	we	we	PRON
fnp-4366	56	9	use	use	VERB
fnp-4366	56	10	deseq2	deseq2	PROPN
fnp-4366	56	11	followed	follow	VERB
fnp-4366	56	12	by	by	ADP
fnp-4366	56	13	fuma	fuma	PROPN
fnp-4366	56	14	and	and	CCONJ
fnp-4366	56	15	reactome	reactome	VERB
fnp-4366	56	16	as	as	ADV
fnp-4366	56	17	well	well	ADV
fnp-4366	56	18	as	as	ADP
fnp-4366	56	19	gsea	gsea	NOUN
fnp-4366	56	20	with	with	ADP
fnp-4366	56	21	normalized	normalize	VERB
fnp-4366	56	22	counts	count	NOUN
fnp-4366	56	23	.	.	PUNCT
fnp-4366	57	1	furthermore	furthermore	ADV
fnp-4366	57	2	,	,	PUNCT
fnp-4366	57	3	exceeding	exceed	VERB
fnp-4366	57	4	the	the	DET
fnp-4366	57	5	biopsy	biopsy	NOUN
fnp-4366	57	6	study	study	NOUN
fnp-4366	57	7	we	we	PRON
fnp-4366	57	8	stain	stain	VERB
fnp-4366	57	9	tissue	tissue	NOUN
fnp-4366	57	10	microarrays	microarray	NOUN
fnp-4366	57	11	for	for	ADP
fnp-4366	57	12	tspo	tspo	NOUN
fnp-4366	57	13	that	that	PRON
fnp-4366	57	14	cover	cover	VERB
fnp-4366	57	15	a	a	DET
fnp-4366	57	16	broader	broad	ADJ
fnp-4366	57	17	spectrum	spectrum	NOUN
fnp-4366	57	18	of	of	ADP
fnp-4366	57	19	human	human	ADJ
fnp-4366	57	20	brain	brain	NOUN
fnp-4366	57	21	pathologies	pathology	NOUN
fnp-4366	57	22	as	as	ADV
fnp-4366	57	23	well	well	ADV
fnp-4366	57	24	as	as	ADP
fnp-4366	57	25	a	a	DET
fnp-4366	57	26	spectrum	spectrum	NOUN
fnp-4366	57	27	of	of	ADP
fnp-4366	57	28	non	non	ADJ
fnp-4366	57	29	-	-	ADJ
fnp-4366	57	30	neoplastic	neoplastic	ADJ
fnp-4366	57	31	tissues	tissue	NOUN
fnp-4366	57	32	from	from	ADP
fnp-4366	57	33	different	different	ADJ
fnp-4366	57	34	brain	brain	NOUN
fnp-4366	57	35	regions	region	NOUN
fnp-4366	57	36	.	.	PUNCT
fnp-4366	58	1	to	to	PART
fnp-4366	58	2	better	well	ADV
fnp-4366	58	3	understand	understand	VERB
fnp-4366	58	4	tspo	tspo	PROPN
fnp-4366	58	5	regulation	regulation	NOUN
fnp-4366	58	6	,	,	PUNCT
fnp-4366	58	7	we	we	PRON
fnp-4366	58	8	consult	consult	VERB
fnp-4366	58	9	data	datum	NOUN
fnp-4366	58	10	of	of	ADP
fnp-4366	58	11	large	large	ADJ
fnp-4366	58	12	patient	patient	ADJ
fnp-4366	58	13	cohorts	cohort	NOUN
fnp-4366	58	14	from	from	ADP
fnp-4366	58	15	the	the	DET
fnp-4366	58	16	tcga	tcga	PROPN
fnp-4366	58	17	database	database	NOUN
fnp-4366	58	18	,	,	PUNCT
fnp-4366	58	19	perform	perform	VERB
fnp-4366	58	20	in	in	ADP
fnp-4366	58	21	vitro	vitro	X
fnp-4366	58	22	epigenetic	epigenetic	ADJ
fnp-4366	58	23	investigations	investigation	NOUN
fnp-4366	58	24	on	on	ADP
fnp-4366	58	25	azaor	azaor	ADJ
fnp-4366	58	26	tsa	tsa	PROPN
fnp-4366	58	27	-	-	PUNCT
fnp-4366	58	28	treated	treat	VERB
fnp-4366	58	29	patient	patient	NOUN
fnp-4366	58	30	-	-	PUNCT
fnp-4366	58	31	derived	derive	VERB
fnp-4366	58	32	glioblastoma	glioblastoma	NOUN
fnp-4366	58	33	cell	cell	NOUN
fnp-4366	58	34	lines	line	NOUN
fnp-4366	58	35	and	and	CCONJ
fnp-4366	58	36	analyze	analyze	VERB
fnp-4366	58	37	the	the	DET
fnp-4366	58	38	tspo	tspo	NOUN
fnp-4366	58	39	promoter	promoter	NOUN
fnp-4366	58	40	in	in	ADP
fnp-4366	58	41	gliomas	glioma	NOUN
fnp-4366	58	42	by	by	ADP
fnp-4366	58	43	direct	direct	ADJ
fnp-4366	58	44	bisulfite	bisulfite	NOUN
fnp-4366	58	45	sequencing	sequencing	NOUN
fnp-4366	58	46	.	.	PUNCT
fnp-4366	59	1	results	result	NOUN
fnp-4366	59	2	:	:	PUNCT
fnp-4366	59	3	we	we	PRON
fnp-4366	59	4	report	report	VERB
fnp-4366	59	5	the	the	DET
fnp-4366	59	6	interim	interim	ADJ
fnp-4366	59	7	analysis	analysis	NOUN
fnp-4366	59	8	of	of	ADP
fnp-4366	59	9	the	the	DET
fnp-4366	59	10	glioma	glioma	NOUN
fnp-4366	59	11	patients	patient	NOUN
fnp-4366	59	12	that	that	PRON
fnp-4366	59	13	have	have	AUX
fnp-4366	59	14	been	be	AUX
fnp-4366	59	15	included	include	VERB
fnp-4366	59	16	and	and	CCONJ
fnp-4366	59	17	fully	fully	ADV
fnp-4366	59	18	histologically	histologically	ADV
fnp-4366	59	19	characterized	characterize	VERB
fnp-4366	59	20	in	in	ADP
fnp-4366	59	21	the	the	DET
fnp-4366	59	22	biopsy	biopsy	NOUN
fnp-4366	59	23	study	study	NOUN
fnp-4366	59	24	so	so	ADV
fnp-4366	59	25	far	far	ADV
fnp-4366	59	26	.	.	PUNCT
fnp-4366	60	1	our	our	PRON
fnp-4366	60	2	results	result	NOUN
fnp-4366	60	3	suggest	suggest	VERB
fnp-4366	60	4	that	that	SCONJ
fnp-4366	60	5	(	(	PUNCT
fnp-4366	60	6	apart	apart	ADV
fnp-4366	60	7	from	from	ADP
fnp-4366	60	8	microglia	microglia	ADJ
fnp-4366	60	9	and	and	CCONJ
fnp-4366	60	10	macrophages	macrophage	NOUN
fnp-4366	60	11	)	)	PUNCT
fnp-4366	60	12	the	the	DET
fnp-4366	60	13	glial	glial	ADJ
fnp-4366	60	14	tumor	tumor	NOUN
fnp-4366	60	15	cells	cell	NOUN
fnp-4366	60	16	relevantly	relevantly	ADV
fnp-4366	60	17	contribute	contribute	VERB
fnp-4366	60	18	to	to	ADP
fnp-4366	60	19	the	the	DET
fnp-4366	60	20	overall	overall	ADJ
fnp-4366	60	21	tspo	tspo	NOUN
fnp-4366	60	22	signal	signal	NOUN
fnp-4366	60	23	in	in	ADP
fnp-4366	60	24	these	these	DET
fnp-4366	60	25	patients	patient	NOUN
fnp-4366	60	26	.	.	PUNCT
fnp-4366	61	1	rna	rna	NOUN
fnp-4366	61	2	-	-	PUNCT
fnp-4366	61	3	seq	seq	NOUN
fnp-4366	61	4	analyses	analysis	NOUN
fnp-4366	61	5	comparing	compare	VERB
fnp-4366	61	6	tspo	tspo	NOUN
fnp-4366	61	7	high	high	ADJ
fnp-4366	61	8	and	and	CCONJ
fnp-4366	61	9	low	low	ADJ
fnp-4366	61	10	regions	region	NOUN
fnp-4366	61	11	(	(	PUNCT
fnp-4366	61	12	both	both	CCONJ
fnp-4366	61	13	by	by	ADP
fnp-4366	61	14	pet	pet	ADJ
fnp-4366	61	15	and	and	CCONJ
fnp-4366	61	16	protein	protein	NOUN
fnp-4366	61	17	expression	expression	NOUN
fnp-4366	61	18	)	)	PUNCT
fnp-4366	61	19	indicate	indicate	VERB
fnp-4366	61	20	three	three	NUM
fnp-4366	61	21	tspo	tspo	NOUN
fnp-4366	61	22	-	-	PUNCT
fnp-4366	61	23	dependent	dependent	ADJ
fnp-4366	61	24	functional	functional	ADJ
fnp-4366	61	25	clusters	cluster	NOUN
fnp-4366	61	26	,	,	PUNCT
fnp-4366	61	27	i.e	i.e	PRON
fnp-4366	61	28	apoptosis	apoptosis	NOUN
fnp-4366	61	29	/	/	SYM
fnp-4366	61	30	dna	dna	PROPN
fnp-4366	61	31	repair	repair	NOUN
fnp-4366	61	32	,	,	PUNCT
fnp-4366	61	33	extracellular	extracellular	ADJ
fnp-4366	61	34	matrix	matrix	NOUN
fnp-4366	61	35	organization	organization	NOUN
fnp-4366	61	36	and	and	CCONJ
fnp-4366	61	37	immune	immune	ADJ
fnp-4366	61	38	system	system	NOUN
fnp-4366	61	39	.	.	PUNCT
fnp-4366	62	1	furthermore	furthermore	ADV
fnp-4366	62	2	the	the	DET
fnp-4366	62	3	tissue	tissue	NOUN
fnp-4366	62	4	microrarrays	microrarray	NOUN
fnp-4366	62	5	show	show	VERB
fnp-4366	62	6	heterogeneity	heterogeneity	NOUN
fnp-4366	62	7	of	of	ADP
fnp-4366	62	8	tspo	tspo	NOUN
fnp-4366	62	9	expression	expression	NOUN
fnp-4366	62	10	between	between	ADP
fnp-4366	62	11	different	different	ADJ
fnp-4366	62	12	brain	brain	NOUN
fnp-4366	62	13	pathologies	pathology	NOUN
fnp-4366	62	14	and	and	CCONJ
fnp-4366	62	15	non	non	ADJ
fnp-4366	62	16	-	-	ADJ
fnp-4366	62	17	neoplastic	neoplastic	ADJ
fnp-4366	62	18	brain	brain	NOUN
fnp-4366	62	19	regions	region	NOUN
fnp-4366	62	20	.	.	PUNCT
fnp-4366	63	1	bringing	bring	VERB
fnp-4366	63	2	this	this	DET
fnp-4366	63	3	information	information	NOUN
fnp-4366	63	4	together	together	ADV
fnp-4366	63	5	with	with	ADP
fnp-4366	63	6	tspo	tspo	NOUN
fnp-4366	63	7	-	-	PUNCT
fnp-4366	63	8	pets	pet	NOUN
fnp-4366	63	9	from	from	ADP
fnp-4366	63	10	respective	respective	ADJ
fnp-4366	63	11	patients	patient	NOUN
fnp-4366	63	12	/	/	SYM
fnp-4366	63	13	brain	brain	NOUN
fnp-4366	63	14	regions	region	NOUN
fnp-4366	63	15	will	will	AUX
fnp-4366	63	16	generate	generate	VERB
fnp-4366	63	17	a	a	DET
fnp-4366	63	18	map	map	NOUN
fnp-4366	63	19	of	of	ADP
fnp-4366	63	20	tspo	tspo	NOUN
fnp-4366	63	21	expression	expression	NOUN
fnp-4366	63	22	in	in	ADP
fnp-4366	63	23	healthy	healthy	ADJ
fnp-4366	63	24	and	and	CCONJ
fnp-4366	63	25	diseased	diseased	ADJ
fnp-4366	63	26	brain	brain	NOUN
fnp-4366	63	27	for	for	ADP
fnp-4366	63	28	clinical	clinical	ADJ
fnp-4366	63	29	use	use	NOUN
fnp-4366	63	30	.	.	PUNCT
fnp-4366	64	1	finally	finally	ADV
fnp-4366	64	2	,	,	PUNCT
fnp-4366	64	3	our	our	PRON
fnp-4366	64	4	epigenetic	epigenetic	ADJ
fnp-4366	64	5	investigations	investigation	NOUN
fnp-4366	64	6	suggest	suggest	VERB
fnp-4366	64	7	that	that	SCONJ
fnp-4366	64	8	a	a	DET
fnp-4366	64	9	loss	loss	NOUN
fnp-4366	64	10	of	of	ADP
fnp-4366	64	11	tspo	tspo	NOUN
fnp-4366	64	12	methylation	methylation	NOUN
fnp-4366	64	13	in	in	ADP
fnp-4366	64	14	high	high	ADJ
fnp-4366	64	15	-	-	PUNCT
fnp-4366	64	16	grade	grade	NOUN
fnp-4366	64	17	neoplasms	neoplasm	NOUN
fnp-4366	64	18	may	may	AUX
fnp-4366	64	19	mechanistically	mechanistically	ADV
fnp-4366	64	20	contribute	contribute	VERB
fnp-4366	64	21	to	to	ADP
fnp-4366	64	22	the	the	DET
fnp-4366	64	23	tspo	tspo	NOUN
fnp-4366	64	24	overexpression	overexpression	NOUN
fnp-4366	64	25	observed	observe	VERB
fnp-4366	64	26	in	in	ADP
fnp-4366	64	27	these	these	DET
fnp-4366	64	28	tumors	tumor	NOUN
fnp-4366	64	29	.	.	PUNCT
fnp-4366	65	1	conclusion	conclusion	NOUN
fnp-4366	65	2	:	:	PUNCT
fnp-4366	65	3	taken	take	VERB
fnp-4366	65	4	together	together	ADV
fnp-4366	65	5	,	,	PUNCT
fnp-4366	65	6	our	our	PRON
fnp-4366	65	7	approach	approach	NOUN
fnp-4366	65	8	of	of	ADP
fnp-4366	65	9	integrating	integrate	VERB
fnp-4366	65	10	histological	histological	ADJ
fnp-4366	65	11	,	,	PUNCT
fnp-4366	65	12	molecular	molecular	ADJ
fnp-4366	65	13	and	and	CCONJ
fnp-4366	65	14	imaging	imaging	NOUN
fnp-4366	65	15	data	datum	NOUN
fnp-4366	65	16	will	will	AUX
fnp-4366	65	17	provide	provide	VERB
fnp-4366	65	18	unique	unique	ADJ
fnp-4366	65	19	insights	insight	NOUN
fnp-4366	65	20	into	into	ADP
fnp-4366	65	21	tspo	tspo	NOUN
fnp-4366	65	22	-	-	PUNCT
fnp-4366	65	23	pet	pet	NOUN
fnp-4366	65	24	enrichment	enrichment	NOUN
fnp-4366	65	25	patterns	pattern	NOUN
fnp-4366	65	26	and	and	CCONJ
fnp-4366	65	27	will	will	AUX
fnp-4366	65	28	help	help	VERB
fnp-4366	65	29	to	to	PART
fnp-4366	65	30	better	well	ADV
fnp-4366	65	31	understand	understand	VERB
fnp-4366	65	32	and	and	CCONJ
fnp-4366	65	33	to	to	PART
fnp-4366	65	34	comprehensively	comprehensively	ADV
fnp-4366	65	35	describe	describe	VERB
fnp-4366	65	36	the	the	DET
fnp-4366	65	37	clinical	clinical	ADJ
fnp-4366	65	38	relevance	relevance	NOUN
fnp-4366	65	39	of	of	ADP
fnp-4366	65	40	this	this	DET
fnp-4366	65	41	novel	novel	ADJ
fnp-4366	65	42	imaging	imaging	NOUN
fnp-4366	65	43	biomarker	biomarker	NOUN
fnp-4366	65	44	.	.	PUNCT
fnp-4366	65	45	  	  	SPACE
fnp-4366	65	46	1.04	1.04	NUM
fnp-4366	65	47	free	free	ADJ
fnp-4366	65	48	neuropathol	neuropathol	NOUN
fnp-4366	65	49	3:20:9	3:20:9	NUM
fnp-4366	65	50	towards	towards	ADP
fnp-4366	65	51	swift	swift	ADJ
fnp-4366	65	52	and	and	CCONJ
fnp-4366	65	53	accessible	accessible	ADJ
fnp-4366	65	54	precision	precision	NOUN
fnp-4366	65	55	cns	cns	NOUN
fnp-4366	65	56	tumour	tumour	NOUN
fnp-4366	65	57	diagnostics	diagnostic	NOUN
fnp-4366	65	58	using	use	VERB
fnp-4366	65	59	third	third	ADJ
fnp-4366	65	60	generation	generation	NOUN
fnp-4366	65	61	sequencing	sequence	VERB
fnp-4366	65	62	and	and	CCONJ
fnp-4366	65	63	deep	deep	ADJ
fnp-4366	65	64	transfer	transfer	NOUN
fnp-4366	65	65	learning	learn	VERB
fnp-4366	65	66	areeba	areeba	PROPN
fnp-4366	65	67	patel1,2	patel1,2	PROPN
fnp-4366	65	68	,	,	PUNCT
fnp-4366	65	69	helin	helin	PROPN
fnp-4366	65	70	dogan1,2	dogan1,2	PROPN
fnp-4366	65	71	,	,	PUNCT
fnp-4366	65	72	alexander	alexander	PROPN
fnp-4366	65	73	wolfgang	wolfgang	PROPN
fnp-4366	65	74	jung3	jung3	PROPN
fnp-4366	65	75	,	,	PUNCT
fnp-4366	65	76	zaira	zaira	PROPN
fnp-4366	65	77	seferbekova4	seferbekova4	PROPN
fnp-4366	65	78	,	,	PUNCT
fnp-4366	65	79	alexander	alexander	PROPN
fnp-4366	65	80	payne5	payne5	PROPN
fnp-4366	65	81	,	,	PUNCT
fnp-4366	65	82	natalie	natalie	PROPN
fnp-4366	65	83	schoebe1,2	schoebe1,2	PROPN
fnp-4366	65	84	,	,	PUNCT
fnp-4366	65	85	elena	elena	PROPN
fnp-4366	65	86	krause1,2	krause1,2	PROPN
fnp-4366	65	87	,	,	PUNCT
fnp-4366	65	88	michael	michael	PROPN
fnp-4366	65	89	ritter1,2	ritter1,2	PROPN
fnp-4366	65	90	,	,	PUNCT
fnp-4366	65	91	daniel	daniel	PROPN
fnp-4366	65	92	schrimpf1,2	schrimpf1,2	PROPN
fnp-4366	65	93	,	,	PUNCT
fnp-4366	65	94	damian	damian	PROPN
fnp-4366	65	95	stichel1,2	stichel1,2	PROPN
fnp-4366	65	96	,	,	PUNCT
fnp-4366	65	97	stefan	stefan	PROPN
fnp-4366	65	98	hammelmann1,2	hammelmann1,2	PROPN
fnp-4366	65	99	,	,	PUNCT
fnp-4366	65	100	christina	christina	PROPN
fnp-4366	65	101	blume1,2	blume1,2	PROPN
fnp-4366	65	102	,	,	PUNCT
fnp-4366	65	103	philipp	philipp	PROPN
fnp-4366	65	104	euskirchen6	euskirchen6	PROPN
fnp-4366	65	105	,	,	PUNCT
fnp-4366	65	106	violaine	violaine	NOUN
fnp-4366	65	107	goidts7	goidts7	PROPN
fnp-4366	65	108	,	,	PUNCT
fnp-4366	65	109	martin	martin	PROPN
fnp-4366	65	110	sill8,9	sill8,9	PROPN
fnp-4366	65	111	,	,	PUNCT
fnp-4366	65	112	stefan	stefan	PROPN
fnp-4366	65	113	pfister8,9	pfister8,9	PROPN
fnp-4366	65	114	,	,	PUNCT
fnp-4366	65	115	matthew	matthew	PROPN
fnp-4366	65	116	loose5	loose5	PROPN
fnp-4366	65	117	,	,	PUNCT
fnp-4366	65	118	wolfgang	wolfgang	PROPN
fnp-4366	65	119	wick10,11	wick10,11	PROPN
fnp-4366	65	120	,	,	PUNCT
fnp-4366	65	121	andreas	andreas	PROPN
fnp-4366	65	122	von	von	PROPN
fnp-4366	65	123	deimling1,2	deimling1,2	PROPN
fnp-4366	65	124	,	,	PUNCT
fnp-4366	65	125	david	david	PROPN
fnp-4366	65	126	jones8,12	jones8,12	PROPN
fnp-4366	65	127	,	,	PUNCT
fnp-4366	65	128	matthias	matthias	PROPN
fnp-4366	65	129	schlesner13	schlesner13	PROPN
fnp-4366	65	130	,	,	PUNCT
fnp-4366	65	131	moritz	moritz	PROPN
fnp-4366	65	132	gerstung3,4	gerstung3,4	PROPN
fnp-4366	65	133	,	,	PUNCT
fnp-4366	65	134	felix	felix	PROPN
fnp-4366	65	135	sahm1,2	sahm1,2	PROPN
fnp-4366	65	136	1	1	NUM
fnp-4366	65	137	german	german	ADJ
fnp-4366	65	138	cancer	cancer	NOUN
fnp-4366	65	139	research	research	NOUN
fnp-4366	65	140	center	center	NOUN
fnp-4366	65	141	,	,	PUNCT
fnp-4366	65	142	clinical	clinical	ADJ
fnp-4366	65	143	cooperation	cooperation	NOUN
fnp-4366	65	144	unit	unit	NOUN
fnp-4366	65	145	neuropathology	neuropathology	NOUN
fnp-4366	65	146	,	,	PUNCT
fnp-4366	65	147	heidelberg	heidelberg	PROPN
fnp-4366	65	148	,	,	PUNCT
fnp-4366	65	149	deutschland	deutschland	NOUN
fnp-4366	65	150	2	2	NUM
fnp-4366	65	151	university	university	NOUN
fnp-4366	65	152	hospital	hospital	NOUN
fnp-4366	65	153	heidelberg	heidelberg	PROPN
fnp-4366	65	154	,	,	PUNCT
fnp-4366	65	155	neuropathology	neuropathology	NOUN
fnp-4366	65	156	,	,	PUNCT
fnp-4366	65	157	heidelberg	heidelberg	PROPN
fnp-4366	65	158	,	,	PUNCT
fnp-4366	65	159	deutschland	deutschland	NOUN
fnp-4366	65	160	3	3	NUM
fnp-4366	65	161	european	european	ADJ
fnp-4366	65	162	molecular	molecular	ADJ
fnp-4366	65	163	biology	biology	NOUN
fnp-4366	65	164	laboratory	laboratory	NOUN
fnp-4366	65	165	,	,	PUNCT
fnp-4366	65	166	european	european	PROPN
fnp-4366	65	167	bioinformatics	bioinformatics	PROPN
fnp-4366	65	168	institute	institute	PROPN
fnp-4366	65	169	embl	embl	PROPN
fnp-4366	65	170	-	-	PUNCT
fnp-4366	65	171	ebi	ebi	PROPN
fnp-4366	65	172	,	,	PUNCT
fnp-4366	65	173	hinxton	hinxton	NOUN
fnp-4366	65	174	,	,	PUNCT
fnp-4366	65	175	united	united	ADJ
fnp-4366	65	176	kingdom	kingdom	PROPN
fnp-4366	65	177	4	4	NUM
fnp-4366	65	178	german	german	ADJ
fnp-4366	65	179	cancer	cancer	NOUN
fnp-4366	65	180	research	research	NOUN
fnp-4366	65	181	center	center	NOUN
fnp-4366	65	182	,	,	PUNCT
fnp-4366	65	183	division	division	NOUN
fnp-4366	65	184	of	of	ADP
fnp-4366	65	185	artificial	artificial	ADJ
fnp-4366	65	186	intelligence	intelligence	NOUN
fnp-4366	65	187	in	in	ADP
fnp-4366	65	188	oncology	oncology	NOUN
fnp-4366	65	189	,	,	PUNCT
fnp-4366	65	190	heidelberg	heidelberg	PROPN
fnp-4366	65	191	,	,	PUNCT
fnp-4366	65	192	united	united	ADJ
fnp-4366	65	193	kingdom	kingdom	PROPN
fnp-4366	65	194	5	5	NUM
fnp-4366	65	195	university	university	PROPN
fnp-4366	65	196	of	of	ADP
fnp-4366	65	197	nottingham	nottingham	PROPN
fnp-4366	65	198	,	,	PUNCT
fnp-4366	65	199	deepseq	deepseq	NOUN
fnp-4366	65	200	,	,	PUNCT
fnp-4366	65	201	school	school	NOUN
fnp-4366	65	202	of	of	ADP
fnp-4366	65	203	life	life	NOUN
fnp-4366	65	204	sciences	sciences	PROPN
fnp-4366	65	205	,	,	PUNCT
fnp-4366	65	206	nottingham	nottingham	PROPN
fnp-4366	65	207	,	,	PUNCT
fnp-4366	65	208	united	united	ADJ
fnp-4366	65	209	kingdom	kingdom	PROPN
fnp-4366	65	210	6	6	NUM
fnp-4366	65	211	charité	charité	VERB
fnp-4366	65	212	-	-	PUNCT
fnp-4366	65	213	universitätsmedizin	universitätsmedizin	PROPN
fnp-4366	65	214	berlin	berlin	PROPN
fnp-4366	65	215	,	,	PUNCT
fnp-4366	65	216	neurology	neurology	NOUN
fnp-4366	65	217	,	,	PUNCT
fnp-4366	65	218	berlin	berlin	PROPN
fnp-4366	65	219	,	,	PUNCT
fnp-4366	65	220	deutschland	deutschland	NOUN
fnp-4366	65	221	7	7	NUM
fnp-4366	65	222	german	german	ADJ
fnp-4366	65	223	cancer	cancer	NOUN
fnp-4366	65	224	research	research	NOUN
fnp-4366	65	225	center	center	NOUN
fnp-4366	65	226	,	,	PUNCT
fnp-4366	65	227	brain	brain	NOUN
fnp-4366	65	228	tumor	tumor	NOUN
fnp-4366	65	229	translational	translational	ADJ
fnp-4366	65	230	targets	target	NOUN
fnp-4366	65	231	,	,	PUNCT
fnp-4366	65	232	heidelberg	heidelberg	NOUN
fnp-4366	65	233	,	,	PUNCT
fnp-4366	65	234	deutschland	deutschland	NOUN
fnp-4366	65	235	8	8	NUM
fnp-4366	65	236	hopp	hopp	PROPN
fnp-4366	65	237	children	child	NOUN
fnp-4366	65	238	's	's	PART
fnp-4366	65	239	cancer	cancer	NOUN
fnp-4366	65	240	center	center	NOUN
fnp-4366	65	241	(	(	PUNCT
fnp-4366	65	242	kitz	kitz	PROPN
fnp-4366	65	243	)	)	PUNCT
fnp-4366	65	244	,	,	PUNCT
fnp-4366	65	245	heidelberg	heidelberg	PROPN
fnp-4366	65	246	,	,	PUNCT
fnp-4366	65	247	deutschland	deutschland	NOUN
fnp-4366	65	248	9	9	NUM
fnp-4366	65	249	german	german	ADJ
fnp-4366	65	250	cancer	cancer	NOUN
fnp-4366	65	251	research	research	NOUN
fnp-4366	65	252	center	center	NOUN
fnp-4366	65	253	,	,	PUNCT
fnp-4366	65	254	division	division	NOUN
fnp-4366	65	255	of	of	ADP
fnp-4366	65	256	pediatric	pediatric	ADJ
fnp-4366	65	257	neurooncology	neurooncology	NOUN
fnp-4366	65	258	,	,	PUNCT
fnp-4366	65	259	heidelberg	heidelberg	PROPN
fnp-4366	65	260	,	,	PUNCT
fnp-4366	65	261	deutschland	deutschland	NOUN
fnp-4366	65	262	10	10	NUM
fnp-4366	65	263	german	german	ADJ
fnp-4366	65	264	cancer	cancer	NOUN
fnp-4366	65	265	research	research	NOUN
fnp-4366	65	266	center	center	NOUN
fnp-4366	65	267	,	,	PUNCT
fnp-4366	65	268	clinical	clinical	ADJ
fnp-4366	65	269	cooperation	cooperation	NOUN
fnp-4366	65	270	unit	unit	NOUN
fnp-4366	65	271	neurooncology	neurooncology	PROPN
fnp-4366	65	272	,	,	PUNCT
fnp-4366	65	273	heidelberg	heidelberg	PROPN
fnp-4366	65	274	,	,	PUNCT
fnp-4366	65	275	deutschland	deutschland	NOUN
fnp-4366	65	276	11	11	NUM
fnp-4366	65	277	national	national	ADJ
fnp-4366	65	278	center	center	NOUN
fnp-4366	65	279	for	for	ADP
fnp-4366	65	280	tumor	tumor	NOUN
fnp-4366	65	281	diseases	disease	NOUN
fnp-4366	65	282	,	,	PUNCT
fnp-4366	65	283	department	department	NOUN
fnp-4366	65	284	of	of	ADP
fnp-4366	65	285	neurology	neurology	NOUN
fnp-4366	65	286	and	and	CCONJ
fnp-4366	65	287	neurooncology	neurooncology	NOUN
fnp-4366	65	288	program	program	NOUN
fnp-4366	65	289	,	,	PUNCT
fnp-4366	65	290	heidelberg	heidelberg	PROPN
fnp-4366	65	291	,	,	PUNCT
fnp-4366	65	292	deutschland	deutschland	NOUN
fnp-4366	65	293	12	12	NUM
fnp-4366	65	294	german	german	ADJ
fnp-4366	65	295	cancer	cancer	NOUN
fnp-4366	65	296	research	research	NOUN
fnp-4366	65	297	center	center	NOUN
fnp-4366	65	298	,	,	PUNCT
fnp-4366	65	299	pediatric	pediatric	ADJ
fnp-4366	65	300	glioma	glioma	NOUN
fnp-4366	65	301	research	research	NOUN
fnp-4366	65	302	group	group	NOUN
fnp-4366	65	303	,	,	PUNCT
fnp-4366	65	304	heidelberg	heidelberg	PROPN
fnp-4366	65	305	,	,	PUNCT
fnp-4366	65	306	deutschland	deutschland	NOUN
fnp-4366	65	307	13	13	NUM
fnp-4366	65	308	augsburg	augsburg	PROPN
fnp-4366	65	309	university	university	NOUN
fnp-4366	65	310	,	,	PUNCT
fnp-4366	65	311	biomedical	biomedical	ADJ
fnp-4366	65	312	informatics	informatic	NOUN
fnp-4366	65	313	,	,	PUNCT
fnp-4366	65	314	data	datum	NOUN
fnp-4366	65	315	mining	mining	NOUN
fnp-4366	65	316	and	and	CCONJ
fnp-4366	65	317	data	datum	NOUN
fnp-4366	65	318	analytics	analytic	NOUN
fnp-4366	65	319	,	,	PUNCT
fnp-4366	65	320	augsburg	augsburg	PROPN
fnp-4366	65	321	,	,	PUNCT
fnp-4366	65	322	deutschland	deutschland	NOUN
fnp-4366	65	323	background	background	NOUN
fnp-4366	65	324	:	:	PUNCT
fnp-4366	65	325	molecular	molecular	ADJ
fnp-4366	65	326	markers	marker	NOUN
fnp-4366	65	327	are	be	AUX
fnp-4366	65	328	now	now	ADV
fnp-4366	65	329	unequivocally	unequivocally	ADV
fnp-4366	65	330	a	a	DET
fnp-4366	65	331	requirement	requirement	NOUN
fnp-4366	65	332	for	for	ADP
fnp-4366	65	333	integrative	integrative	ADJ
fnp-4366	65	334	brain	brain	NOUN
fnp-4366	65	335	tumour	tumour	NOUN
fnp-4366	65	336	diagnostics	diagnostic	NOUN
fnp-4366	65	337	.	.	PUNCT
fnp-4366	66	1	the	the	DET
fnp-4366	66	2	2021	2021	NUM
fnp-4366	66	3	who	who	PRON
fnp-4366	66	4	classification	classification	NOUN
fnp-4366	66	5	of	of	ADP
fnp-4366	66	6	central	central	ADJ
fnp-4366	66	7	nervous	nervous	ADJ
fnp-4366	66	8	system	system	NOUN
fnp-4366	66	9	(	(	PUNCT
fnp-4366	66	10	cns	cns	NOUN
fnp-4366	66	11	)	)	PUNCT
fnp-4366	66	12	tumours	tumour	NOUN
fnp-4366	66	13	substantially	substantially	ADV
fnp-4366	66	14	increases	increase	VERB
fnp-4366	66	15	the	the	DET
fnp-4366	66	16	set	set	NOUN
fnp-4366	66	17	of	of	ADP
fnp-4366	66	18	genes	gene	NOUN
fnp-4366	66	19	required	require	VERB
fnp-4366	66	20	in	in	ADP
fnp-4366	66	21	routine	routine	ADJ
fnp-4366	66	22	evaluation	evaluation	NOUN
fnp-4366	66	23	,	,	PUNCT
fnp-4366	66	24	and	and	CCONJ
fnp-4366	66	25	significantly	significantly	ADV
fnp-4366	66	26	increases	increase	VERB
fnp-4366	66	27	the	the	DET
fnp-4366	66	28	relevance	relevance	NOUN
fnp-4366	66	29	of	of	ADP
fnp-4366	66	30	dna	dna	PROPN
fnp-4366	66	31	methylation	methylation	NOUN
fnp-4366	66	32	analysis	analysis	NOUN
fnp-4366	66	33	in	in	ADP
fnp-4366	66	34	the	the	DET
fnp-4366	66	35	diagnostic	diagnostic	ADJ
fnp-4366	66	36	process	process	NOUN
fnp-4366	66	37	.	.	PUNCT
fnp-4366	67	1	owing	owe	VERB
fnp-4366	67	2	to	to	ADP
fnp-4366	67	3	extensive	extensive	ADJ
fnp-4366	67	4	setup	setup	NOUN
fnp-4366	67	5	costs	cost	NOUN
fnp-4366	67	6	and	and	CCONJ
fnp-4366	67	7	batch	batch	NOUN
fnp-4366	67	8	requirements	requirement	NOUN
fnp-4366	67	9	,	,	PUNCT
fnp-4366	67	10	smaller	small	ADJ
fnp-4366	67	11	labs	lab	NOUN
fnp-4366	67	12	and	and	CCONJ
fnp-4366	67	13	clinics	clinic	NOUN
fnp-4366	67	14	might	might	AUX
fnp-4366	67	15	not	not	PART
fnp-4366	67	16	be	be	AUX
fnp-4366	67	17	able	able	ADJ
fnp-4366	67	18	to	to	PART
fnp-4366	67	19	deliver	deliver	VERB
fnp-4366	67	20	molecular	molecular	ADJ
fnp-4366	67	21	results	result	NOUN
fnp-4366	67	22	for	for	ADP
fnp-4366	67	23	prompt	prompt	ADJ
fnp-4366	67	24	clinical	clinical	ADJ
fnp-4366	67	25	decisions	decision	NOUN
fnp-4366	67	26	.	.	PUNCT
fnp-4366	68	1	deep	deep	ADJ
fnp-4366	68	2	neural	neural	ADJ
fnp-4366	68	3	network	network	NOUN
fnp-4366	68	4	architectures	architecture	NOUN
fnp-4366	68	5	have	have	AUX
fnp-4366	68	6	been	be	AUX
fnp-4366	68	7	shown	show	VERB
fnp-4366	68	8	to	to	PART
fnp-4366	68	9	predict	predict	VERB
fnp-4366	68	10	whole	whole	ADJ
fnp-4366	68	11	genome	genome	NOUN
fnp-4366	68	12	duplications	duplication	NOUN
fnp-4366	68	13	,	,	PUNCT
fnp-4366	68	14	driver	driver	NOUN
fnp-4366	68	15	gene	gene	NOUN
fnp-4366	68	16	mutations	mutation	NOUN
fnp-4366	68	17	,	,	PUNCT
fnp-4366	68	18	transcriptomic	transcriptomic	ADJ
fnp-4366	68	19	associations	association	NOUN
fnp-4366	68	20	,	,	PUNCT
fnp-4366	68	21	immune	immune	ADJ
fnp-4366	68	22	cell	cell	NOUN
fnp-4366	68	23	localisation	localisation	NOUN
fnp-4366	68	24	and	and	CCONJ
fnp-4366	68	25	prognostic	prognostic	ADJ
fnp-4366	68	26	effects	effect	NOUN
fnp-4366	68	27	from	from	ADP
fnp-4366	68	28	h&e	h&e	PROPN
fnp-4366	68	29	slides	slide	NOUN
fnp-4366	68	30	.	.	PUNCT
fnp-4366	69	1	third	third	ADJ
fnp-4366	69	2	generation	generation	NOUN
fnp-4366	69	3	sequencing	sequencing	NOUN
fnp-4366	69	4	has	have	AUX
fnp-4366	69	5	enabled	enable	VERB
fnp-4366	69	6	sequencing	sequence	VERB
fnp-4366	69	7	longer	long	ADJ
fnp-4366	69	8	reads	read	NOUN
fnp-4366	69	9	,	,	PUNCT
fnp-4366	69	10	shorter	short	ADJ
fnp-4366	69	11	library	library	NOUN
fnp-4366	69	12	preparation	preparation	NOUN
fnp-4366	69	13	protocols	protocol	NOUN
fnp-4366	69	14	,	,	PUNCT
fnp-4366	69	15	ability	ability	NOUN
fnp-4366	69	16	to	to	PART
fnp-4366	69	17	call	call	VERB
fnp-4366	69	18	base	base	NOUN
fnp-4366	69	19	modifications	modification	NOUN
fnp-4366	69	20	natively	natively	ADV
fnp-4366	69	21	,	,	PUNCT
fnp-4366	69	22	real	real	ADJ
fnp-4366	69	23	time	time	NOUN
fnp-4366	69	24	analysis	analysis	NOUN
fnp-4366	69	25	,	,	PUNCT
fnp-4366	69	26	and	and	CCONJ
fnp-4366	69	27	low	low	ADJ
fnp-4366	69	28	-	-	PUNCT
fnp-4366	69	29	cost	cost	NOUN
fnp-4366	69	30	,	,	PUNCT
fnp-4366	69	31	portable	portable	ADJ
fnp-4366	69	32	devices	device	NOUN
fnp-4366	69	33	.	.	PUNCT
fnp-4366	70	1	aims	aim	VERB
fnp-4366	70	2	:	:	PUNCT
fnp-4366	70	3	to	to	PART
fnp-4366	70	4	make	make	VERB
fnp-4366	70	5	precision	precision	NOUN
fnp-4366	70	6	diagnostics	diagnostic	NOUN
fnp-4366	70	7	accessible	accessible	ADJ
fnp-4366	70	8	,	,	PUNCT
fnp-4366	70	9	we	we	PRON
fnp-4366	70	10	introduce	introduce	VERB
fnp-4366	70	11	an	an	DET
fnp-4366	70	12	integrated	integrated	ADJ
fnp-4366	70	13	computational	computational	ADJ
fnp-4366	70	14	histopathology	histopathology	NOUN
fnp-4366	70	15	and	and	CCONJ
fnp-4366	70	16	third	third	ADJ
fnp-4366	70	17	generation	generation	NOUN
fnp-4366	70	18	sequencing	sequence	VERB
fnp-4366	70	19	workflow	workflow	NOUN
fnp-4366	70	20	for	for	ADP
fnp-4366	70	21	real	real	ADJ
fnp-4366	70	22	-	-	PUNCT
fnp-4366	70	23	time	time	NOUN
fnp-4366	70	24	cns	cns	NOUN
fnp-4366	70	25	tumour	tumour	NOUN
fnp-4366	70	26	molecular	molecular	ADJ
fnp-4366	70	27	diagnostics	diagnostic	NOUN
fnp-4366	70	28	.	.	PUNCT
fnp-4366	71	1	methods	method	NOUN
fnp-4366	71	2	:	:	PUNCT
fnp-4366	71	3	we	we	PRON
fnp-4366	71	4	present	present	VERB
fnp-4366	71	5	cns	cns	NOUN
fnp-4366	71	6	-	-	PUNCT
fnp-4366	71	7	chipa	chipa	NOUN
fnp-4366	71	8	multi	multi	ADJ
fnp-4366	71	9	-	-	ADJ
fnp-4366	71	10	task	task	ADJ
fnp-4366	71	11	lightweight	lightweight	ADJ
fnp-4366	71	12	deep	deep	ADJ
fnp-4366	71	13	transfer	transfer	NOUN
fnp-4366	71	14	learning	learn	VERB
fnp-4366	71	15	model	model	NOUN
fnp-4366	71	16	to	to	PART
fnp-4366	71	17	predict	predict	VERB
fnp-4366	71	18	key	key	ADJ
fnp-4366	71	19	molecular	molecular	ADJ
fnp-4366	71	20	alterations	alteration	NOUN
fnp-4366	71	21	,	,	PUNCT
fnp-4366	71	22	methylation	methylation	NOUN
fnp-4366	71	23	classification	classification	NOUN
fnp-4366	71	24	and	and	CCONJ
fnp-4366	71	25	survival	survival	NOUN
fnp-4366	71	26	from	from	ADP
fnp-4366	71	27	h&e	h&e	PROPN
fnp-4366	71	28	stained	stain	VERB
fnp-4366	71	29	cns	cns	NOUN
fnp-4366	71	30	tumour	tumour	NOUN
fnp-4366	71	31	slides	slide	NOUN
fnp-4366	71	32	.	.	PUNCT
fnp-4366	72	1	the	the	DET
fnp-4366	72	2	model	model	NOUN
fnp-4366	72	3	provided	provide	VERB
fnp-4366	72	4	basic	basic	ADJ
fnp-4366	72	5	information	information	NOUN
fnp-4366	72	6	regarding	regard	VERB
fnp-4366	72	7	the	the	DET
fnp-4366	72	8	tumor	tumor	NOUN
fnp-4366	72	9	type	type	NOUN
fnp-4366	72	10	instantly	instantly	ADV
fnp-4366	72	11	.	.	PUNCT
fnp-4366	73	1	for	for	ADP
fnp-4366	73	2	further	further	ADJ
fnp-4366	73	3	detail	detail	NOUN
fnp-4366	73	4	(	(	PUNCT
fnp-4366	73	5	e.g.	e.g.	ADV
fnp-4366	73	6	variant	variant	NOUN
fnp-4366	73	7	of	of	ADP
fnp-4366	73	8	idh	idh	PROPN
fnp-4366	73	9	alteration	alteration	NOUN
fnp-4366	73	10	)	)	PUNCT
fnp-4366	73	11	and	and	CCONJ
fnp-4366	73	12	subtyping	subtype	VERB
fnp-4366	73	13	,	,	PUNCT
fnp-4366	73	14	we	we	PRON
fnp-4366	73	15	subsequently	subsequently	ADV
fnp-4366	73	16	used	use	VERB
fnp-4366	73	17	the	the	DET
fnp-4366	73	18	predictions	prediction	NOUN
fnp-4366	73	19	to	to	PART
fnp-4366	73	20	formulate	formulate	VERB
fnp-4366	73	21	a	a	DET
fnp-4366	73	22	custom	custom	NOUN
fnp-4366	73	23	panel	panel	NOUN
fnp-4366	73	24	for	for	ADP
fnp-4366	73	25	each	each	DET
fnp-4366	73	26	patient	patient	NOUN
fnp-4366	73	27	.	.	PUNCT
fnp-4366	74	1	targeted	target	VERB
fnp-4366	74	2	sequencing	sequencing	NOUN
fnp-4366	74	3	and	and	CCONJ
fnp-4366	74	4	analyses	analysis	NOUN
fnp-4366	74	5	were	be	AUX
fnp-4366	74	6	performed	perform	VERB
fnp-4366	74	7	using	use	VERB
fnp-4366	74	8	rapid	rapid	ADJ
fnp-4366	74	9	-	-	PUNCT
fnp-4366	74	10	cns2a	cns2a	NOUN
fnp-4366	74	11	custom	custom	NOUN
fnp-4366	74	12	neurooncology	neurooncology	NOUN
fnp-4366	74	13	third	third	ADJ
fnp-4366	74	14	generation	generation	NOUN
fnp-4366	74	15	sequencing	sequence	VERB
fnp-4366	74	16	pipeline	pipeline	NOUN
fnp-4366	74	17	for	for	ADP
fnp-4366	74	18	parallel	parallel	ADJ
fnp-4366	74	19	copy	copy	NOUN
fnp-4366	74	20	-	-	PUNCT
fnp-4366	74	21	number	number	NOUN
fnp-4366	74	22	profiling	profiling	NOUN
fnp-4366	74	23	,	,	PUNCT
fnp-4366	74	24	mutational	mutational	ADJ
fnp-4366	74	25	and	and	CCONJ
fnp-4366	74	26	methylation	methylation	NOUN
fnp-4366	74	27	analysis	analysis	NOUN
fnp-4366	74	28	that	that	PRON
fnp-4366	74	29	is	be	AUX
fnp-4366	74	30	highly	highly	ADV
fnp-4366	74	31	flexible	flexible	ADJ
fnp-4366	74	32	in	in	ADP
fnp-4366	74	33	target	target	NOUN
fnp-4366	74	34	selection	selection	NOUN
fnp-4366	74	35	,	,	PUNCT
fnp-4366	74	36	requires	require	VERB
fnp-4366	74	37	no	no	DET
fnp-4366	74	38	additional	additional	ADJ
fnp-4366	74	39	library	library	NOUN
fnp-4366	74	40	preparation	preparation	NOUN
fnp-4366	74	41	for	for	ADP
fnp-4366	74	42	targeting	target	VERB
fnp-4366	74	43	,	,	PUNCT
fnp-4366	74	44	runs	run	VERB
fnp-4366	74	45	efficiently	efficiently	ADV
fnp-4366	74	46	on	on	ADP
fnp-4366	74	47	single	single	ADJ
fnp-4366	74	48	samples	sample	NOUN
fnp-4366	74	49	,	,	PUNCT
fnp-4366	74	50	and	and	CCONJ
fnp-4366	74	51	can	can	AUX
fnp-4366	74	52	be	be	AUX
fnp-4366	74	53	initiated	initiate	VERB
fnp-4366	74	54	upon	upon	SCONJ
fnp-4366	74	55	receipt	receipt	NOUN
fnp-4366	74	56	of	of	ADP
fnp-4366	74	57	frozen	frozen	ADJ
fnp-4366	74	58	sections	section	NOUN
fnp-4366	74	59	.	.	PUNCT
fnp-4366	75	1	rapid	rapid	ADJ
fnp-4366	75	2	-	-	PUNCT
fnp-4366	75	3	cns2	cns2	NOUN
fnp-4366	75	4	leverages	leverage	NOUN
fnp-4366	75	5	adaptive	adaptive	ADJ
fnp-4366	75	6	sampling	sample	VERB
fnp-4366	75	7	through	through	ADP
fnp-4366	75	8	readfish	readfish	NOUN
fnp-4366	75	9	and	and	CCONJ
fnp-4366	75	10	was	be	AUX
fnp-4366	75	11	run	run	VERB
fnp-4366	75	12	using	use	VERB
fnp-4366	75	13	a	a	DET
fnp-4366	75	14	portable	portable	ADJ
fnp-4366	75	15	minion	minion	NOUN
fnp-4366	75	16	or	or	CCONJ
fnp-4366	75	17	gridion	gridion	NOUN
fnp-4366	75	18	device	device	NOUN
fnp-4366	75	19	.	.	PUNCT
fnp-4366	76	1	results	result	NOUN
fnp-4366	76	2	:	:	PUNCT
fnp-4366	76	3	we	we	PRON
fnp-4366	76	4	show	show	VERB
fnp-4366	76	5	that	that	SCONJ
fnp-4366	76	6	cns	cns	NOUN
fnp-4366	76	7	-	-	PUNCT
fnp-4366	76	8	chip	chip	NOUN
fnp-4366	76	9	can	can	AUX
fnp-4366	76	10	predict	predict	VERB
fnp-4366	76	11	a	a	DET
fnp-4366	76	12	multitude	multitude	NOUN
fnp-4366	76	13	of	of	ADP
fnp-4366	76	14	key	key	ADJ
fnp-4366	76	15	pathognomonic	pathognomonic	ADJ
fnp-4366	76	16	alterations	alteration	NOUN
fnp-4366	76	17	(	(	PUNCT
fnp-4366	76	18	eg	eg	NOUN
fnp-4366	76	19	.	.	PUNCT
fnp-4366	77	1	idh	idh	PROPN
fnp-4366	77	2	mutation	mutation	NOUN
fnp-4366	77	3	,	,	PUNCT
fnp-4366	77	4	7	7	NUM
fnp-4366	77	5	gain/10	gain/10	NOUN
fnp-4366	77	6	loss	loss	NOUN
fnp-4366	77	7	,	,	PUNCT
fnp-4366	77	8	etc	etc	X
fnp-4366	77	9	.	.	X
fnp-4366	77	10	)	)	PUNCT
fnp-4366	78	1	using	use	VERB
fnp-4366	78	2	a	a	DET
fnp-4366	78	3	single	single	ADJ
fnp-4366	78	4	model	model	NOUN
fnp-4366	78	5	with	with	ADP
fnp-4366	78	6	reasonable	reasonable	ADJ
fnp-4366	78	7	accuracy	accuracy	NOUN
fnp-4366	78	8	.	.	PUNCT
fnp-4366	79	1	using	use	VERB
fnp-4366	79	2	a	a	DET
fnp-4366	79	3	personalised	personalised	ADJ
fnp-4366	79	4	panel	panel	NOUN
fnp-4366	79	5	for	for	ADP
fnp-4366	79	6	targeted	target	VERB
fnp-4366	79	7	sequencing	sequencing	NOUN
fnp-4366	79	8	of	of	ADP
fnp-4366	79	9	each	each	DET
fnp-4366	79	10	sample	sample	NOUN
fnp-4366	79	11	enabled	enable	VERB
fnp-4366	79	12	smaller	small	ADJ
fnp-4366	79	13	target	target	NOUN
fnp-4366	79	14	sizes	size	NOUN
fnp-4366	79	15	,	,	PUNCT
fnp-4366	79	16	thus	thus	ADV
fnp-4366	79	17	reducing	reduce	VERB
fnp-4366	79	18	sequencing	sequence	VERB
fnp-4366	79	19	time	time	NOUN
fnp-4366	79	20	to	to	ADP
fnp-4366	79	21	an	an	DET
fnp-4366	79	22	average	average	NOUN
fnp-4366	79	23	of	of	ADP
fnp-4366	79	24	24	24	NUM
fnp-4366	79	25	hours	hour	NOUN
fnp-4366	79	26	.	.	PUNCT
fnp-4366	80	1	cns	cns	NOUN
fnp-4366	80	2	-	-	PUNCT
fnp-4366	80	3	chip	chip	NOUN
fnp-4366	80	4	predictions	prediction	NOUN
fnp-4366	80	5	were	be	AUX
fnp-4366	80	6	compared	compare	VERB
fnp-4366	80	7	to	to	ADP
fnp-4366	80	8	their	their	PRON
fnp-4366	80	9	respective	respective	ADJ
fnp-4366	80	10	rapid	rapid	ADJ
fnp-4366	80	11	-	-	PUNCT
fnp-4366	80	12	cns2	cns2	NOUN
fnp-4366	80	13	results	result	NOUN
fnp-4366	80	14	and	and	CCONJ
fnp-4366	80	15	corresponding	corresponding	ADJ
fnp-4366	80	16	conventional	conventional	ADJ
fnp-4366	80	17	data	datum	NOUN
fnp-4366	80	18	(	(	PUNCT
fnp-4366	80	19	ngs	ng	NOUN
fnp-4366	80	20	panel	panel	NOUN
fnp-4366	80	21	sequencing	sequence	VERB
fnp-4366	80	22	and	and	CCONJ
fnp-4366	80	23	epic	epic	ADJ
fnp-4366	80	24	array	array	NOUN
fnp-4366	80	25	analysis	analysis	NOUN
fnp-4366	80	26	)	)	PUNCT
fnp-4366	80	27	.	.	PUNCT
fnp-4366	81	1	we	we	PRON
fnp-4366	81	2	demonstrate	demonstrate	VERB
fnp-4366	81	3	our	our	PRON
fnp-4366	81	4	workflow	workflow	NOUN
fnp-4366	81	5	on	on	ADP
fnp-4366	81	6	prospective	prospective	ADJ
fnp-4366	81	7	diagnostic	diagnostic	ADJ
fnp-4366	81	8	samples	sample	NOUN
fnp-4366	81	9	received	receive	VERB
fnp-4366	81	10	by	by	ADP
fnp-4366	81	11	the	the	DET
fnp-4366	81	12	department	department	PROPN
fnp-4366	81	13	of	of	ADP
fnp-4366	81	14	neuropathology	neuropathology	NOUN
fnp-4366	81	15	,	,	PUNCT
fnp-4366	81	16	university	university	NOUN
fnp-4366	81	17	hospital	hospital	NOUN
fnp-4366	81	18	heidelberg	heidelberg	PROPN
fnp-4366	81	19	.	.	PUNCT
fnp-4366	82	1	the	the	DET
fnp-4366	82	2	average	average	ADJ
fnp-4366	82	3	turnaround	turnaround	NOUN
fnp-4366	82	4	time	time	NOUN
fnp-4366	82	5	per	per	ADP
fnp-4366	82	6	sample	sample	NOUN
fnp-4366	82	7	was	be	AUX
fnp-4366	82	8	48h	48h	NOUN
fnp-4366	82	9	.	.	PUNCT
fnp-4366	83	1	conclusions	conclusion	NOUN
fnp-4366	83	2	:	:	PUNCT
fnp-4366	83	3	our	our	PRON
fnp-4366	83	4	workflow	workflow	NOUN
fnp-4366	83	5	harnessing	harness	VERB
fnp-4366	83	6	histology	histology	NOUN
fnp-4366	83	7	-	-	PUNCT
fnp-4366	83	8	based	base	VERB
fnp-4366	83	9	molecular	molecular	ADJ
fnp-4366	83	10	predictions	prediction	NOUN
fnp-4366	83	11	to	to	PART
fnp-4366	83	12	instruct	instruct	VERB
fnp-4366	83	13	targeted	targeted	ADJ
fnp-4366	83	14	sequencing	sequencing	NOUN
fnp-4366	83	15	can	can	AUX
fnp-4366	83	16	be	be	AUX
fnp-4366	83	17	set	set	VERB
fnp-4366	83	18	up	up	ADP
fnp-4366	83	19	with	with	ADP
fnp-4366	83	20	low	low	ADJ
fnp-4366	83	21	initial	initial	ADJ
fnp-4366	83	22	investment	investment	NOUN
fnp-4366	83	23	,	,	PUNCT
fnp-4366	83	24	reduces	reduce	VERB
fnp-4366	83	25	hands	hand	NOUN
fnp-4366	83	26	-	-	PUNCT
fnp-4366	83	27	on	on	ADP
fnp-4366	83	28	time	time	NOUN
fnp-4366	83	29	and	and	CCONJ
fnp-4366	83	30	has	have	VERB
fnp-4366	83	31	the	the	DET
fnp-4366	83	32	potential	potential	NOUN
fnp-4366	83	33	to	to	PART
fnp-4366	83	34	facilitate	facilitate	VERB
fnp-4366	83	35	reporting	reporting	NOUN
fnp-4366	83	36	of	of	ADP
fnp-4366	83	37	integrated	integrate	VERB
fnp-4366	83	38	molecular	molecular	ADJ
fnp-4366	83	39	diagnostic	diagnostic	ADJ
fnp-4366	83	40	results	result	NOUN
fnp-4366	83	41	in	in	ADP
fnp-4366	83	42	less	less	ADJ
fnp-4366	83	43	than	than	ADP
fnp-4366	83	44	48h	48h	NOUN
fnp-4366	83	45	.	.	PUNCT
fnp-4366	84	1	cns	cns	NOUN
fnp-4366	84	2	-	-	PUNCT
fnp-4366	84	3	chip	chip	NOUN
fnp-4366	84	4	combined	combine	VERB
fnp-4366	84	5	with	with	ADP
fnp-4366	84	6	rapid	rapid	ADJ
fnp-4366	84	7	-	-	PUNCT
fnp-4366	84	8	cns2	cns2	NOUN
fnp-4366	84	9	thus	thus	ADV
fnp-4366	84	10	aims	aim	VERB
fnp-4366	84	11	to	to	PART
fnp-4366	84	12	make	make	VERB
fnp-4366	84	13	cns	cns	NOUN
fnp-4366	84	14	molecular	molecular	ADJ
fnp-4366	84	15	diagnostics	diagnostic	NOUN
fnp-4366	84	16	affordable	affordable	ADJ
fnp-4366	84	17	and	and	CCONJ
fnp-4366	84	18	accessible	accessible	ADJ
fnp-4366	84	19	to	to	ADP
fnp-4366	84	20	smaller	small	ADJ
fnp-4366	84	21	hospitals	hospital	NOUN
fnp-4366	84	22	and	and	CCONJ
fnp-4366	84	23	labs	lab	NOUN
fnp-4366	84	24	especially	especially	ADV
fnp-4366	84	25	in	in	ADP
fnp-4366	84	26	lowand	lowand	ADJ
fnp-4366	84	27	middle	middle	ADJ
fnp-4366	84	28	-	-	PUNCT
fnp-4366	84	29	income	income	NOUN
fnp-4366	84	30	countries	country	NOUN
fnp-4366	84	31	.	.	PUNCT
fnp-4366	84	32	  	  	SPACE
fnp-4366	85	1	1.05	1.05	NUM
fnp-4366	85	2	free	free	ADJ
fnp-4366	85	3	neuropathol	neuropathol	NOUN
fnp-4366	85	4	3:20:11	3:20:11	NUM
fnp-4366	85	5	retinal	retinal	ADJ
fnp-4366	85	6	pathology	pathology	NOUN
fnp-4366	85	7	as	as	ADP
fnp-4366	85	8	potential	potential	ADJ
fnp-4366	85	9	biomarker	biomarker	NOUN
fnp-4366	85	10	of	of	ADP
fnp-4366	85	11	symptom	symptom	NOUN
fnp-4366	85	12	severity	severity	NOUN
fnp-4366	85	13	and	and	CCONJ
fnp-4366	85	14	impairment	impairment	NOUN
fnp-4366	85	15	in	in	ADP
fnp-4366	85	16	patients	patient	NOUN
fnp-4366	85	17	with	with	ADP
fnp-4366	85	18	stiff	stiff	ADJ
fnp-4366	85	19	person	person	NOUN
fnp-4366	85	20	syndrome	syndrome	PROPN
fnp-4366	85	21	sabine	sabine	PROPN
fnp-4366	85	22	seefried1	seefried1	PROPN
fnp-4366	85	23	,	,	PUNCT
fnp-4366	85	24	claudia	claudia	X
fnp-4366	85	25	sommer1	sommer1	NOUN
fnp-4366	85	26	1	1	NUM
fnp-4366	85	27	ukw	ukw	PROPN
fnp-4366	85	28	,	,	PUNCT
fnp-4366	85	29	würzburg	würzburg	PROPN
fnp-4366	85	30	,	,	PUNCT
fnp-4366	85	31	deutschland	deutschland	NOUN
fnp-4366	85	32	background	background	NOUN
fnp-4366	85	33	:	:	PUNCT
fnp-4366	85	34	stiff	stiff	ADJ
fnp-4366	85	35	-	-	PUNCT
fnp-4366	85	36	person	person	NOUN
fnp-4366	85	37	syndrome	syndrome	NOUN
fnp-4366	85	38	(	(	PUNCT
fnp-4366	85	39	sps	sps	PROPN
fnp-4366	85	40	)	)	PUNCT
fnp-4366	85	41	is	be	AUX
fnp-4366	85	42	a	a	DET
fnp-4366	85	43	rare	rare	ADJ
fnp-4366	85	44	chronic	chronic	ADJ
fnp-4366	85	45	autoimmune	autoimmune	ADJ
fnp-4366	85	46	disease	disease	NOUN
fnp-4366	85	47	characterized	characterize	VERB
fnp-4366	85	48	by	by	ADP
fnp-4366	85	49	painful	painful	ADJ
fnp-4366	85	50	spasms	spasm	NOUN
fnp-4366	85	51	and	and	CCONJ
fnp-4366	85	52	rigidity	rigidity	NOUN
fnp-4366	85	53	,	,	PUNCT
fnp-4366	85	54	predominantly	predominantly	ADV
fnp-4366	85	55	of	of	ADP
fnp-4366	85	56	the	the	DET
fnp-4366	85	57	axial	axial	ADJ
fnp-4366	85	58	and	and	CCONJ
fnp-4366	85	59	lower	low	ADJ
fnp-4366	85	60	extremity	extremity	NOUN
fnp-4366	85	61	muscles	muscle	NOUN
fnp-4366	85	62	.	.	PUNCT
fnp-4366	86	1	autoantibodies	autoantibody	NOUN
fnp-4366	86	2	have	have	AUX
fnp-4366	86	3	been	be	AUX
fnp-4366	86	4	reported	report	VERB
fnp-4366	86	5	in	in	ADP
fnp-4366	86	6	80	80	NUM
fnp-4366	86	7	%	%	NOUN
fnp-4366	86	8	of	of	ADP
fnp-4366	86	9	cases	case	NOUN
fnp-4366	86	10	,	,	PUNCT
fnp-4366	86	11	disrupting	disrupt	VERB
fnp-4366	86	12	the	the	DET
fnp-4366	86	13	function	function	NOUN
fnp-4366	86	14	of	of	ADP
fnp-4366	86	15	the	the	DET
fnp-4366	86	16	inhibitory	inhibitory	ADJ
fnp-4366	86	17	neurotransmitters	neurotransmitter	NOUN
fnp-4366	86	18	gaba	gaba	PROPN
fnp-4366	86	19	and	and	CCONJ
fnp-4366	86	20	glycine	glycine	NOUN
fnp-4366	86	21	,	,	PUNCT
fnp-4366	86	22	and	and	CCONJ
fnp-4366	86	23	leading	lead	VERB
fnp-4366	86	24	to	to	ADP
fnp-4366	86	25	overexcitability	overexcitability	NOUN
fnp-4366	86	26	of	of	ADP
fnp-4366	86	27	the	the	DET
fnp-4366	86	28	neuromuscular	neuromuscular	ADJ
fnp-4366	86	29	system	system	NOUN
fnp-4366	86	30	and	and	CCONJ
fnp-4366	86	31	psychological	psychological	ADJ
fnp-4366	86	32	comorbidities	comorbiditie	NOUN
fnp-4366	86	33	.	.	PUNCT
fnp-4366	87	1	since	since	SCONJ
fnp-4366	87	2	the	the	DET
fnp-4366	87	3	retina	retina	NOUN
fnp-4366	87	4	is	be	AUX
fnp-4366	87	5	highly	highly	ADV
fnp-4366	87	6	enriched	enriched	ADJ
fnp-4366	87	7	with	with	ADP
fnp-4366	87	8	gabaergic	gabaergic	ADJ
fnp-4366	87	9	neurons	neuron	NOUN
fnp-4366	87	10	,	,	PUNCT
fnp-4366	87	11	retinal	retinal	ADJ
fnp-4366	87	12	pathology	pathology	NOUN
fnp-4366	87	13	may	may	AUX
fnp-4366	87	14	occur	occur	VERB
fnp-4366	87	15	in	in	ADP
fnp-4366	87	16	sps	sps	PROPN
fnp-4366	87	17	,	,	PUNCT
fnp-4366	87	18	especially	especially	ADV
fnp-4366	87	19	in	in	ADP
fnp-4366	87	20	the	the	DET
fnp-4366	87	21	ganglion	ganglion	NOUN
fnp-4366	87	22	cell	cell	NOUN
fnp-4366	87	23	and	and	CCONJ
fnp-4366	87	24	inner	inner	ADJ
fnp-4366	87	25	plexiform	plexiform	NOUN
fnp-4366	87	26	layer	layer	NOUN
fnp-4366	87	27	(	(	PUNCT
fnp-4366	87	28	gcipl	gcipl	PROPN
fnp-4366	87	29	)	)	PUNCT
fnp-4366	87	30	of	of	ADP
fnp-4366	87	31	the	the	DET
fnp-4366	87	32	retina	retina	NOUN
fnp-4366	87	33	,	,	PUNCT
fnp-4366	87	34	which	which	PRON
fnp-4366	87	35	contains	contain	VERB
fnp-4366	87	36	most	most	ADJ
fnp-4366	87	37	of	of	ADP
fnp-4366	87	38	the	the	DET
fnp-4366	87	39	retinal	retinal	ADJ
fnp-4366	87	40	gabaergic	gabaergic	ADJ
fnp-4366	87	41	neurons	neuron	NOUN
fnp-4366	87	42	.	.	PUNCT
fnp-4366	88	1	study	study	NOUN
fnp-4366	88	2	aims	aim	VERB
fnp-4366	88	3	:	:	PUNCT
fnp-4366	88	4	we	we	PRON
fnp-4366	88	5	aimed	aim	VERB
fnp-4366	88	6	to	to	PART
fnp-4366	88	7	detect	detect	VERB
fnp-4366	88	8	potential	potential	ADJ
fnp-4366	88	9	abnormalities	abnormality	NOUN
fnp-4366	88	10	in	in	ADP
fnp-4366	88	11	the	the	DET
fnp-4366	88	12	retina	retina	NOUN
fnp-4366	88	13	in	in	ADP
fnp-4366	88	14	sps	sps	NOUN
fnp-4366	88	15	patients	patient	NOUN
fnp-4366	88	16	and	and	CCONJ
fnp-4366	88	17	correlate	correlate	VERB
fnp-4366	88	18	these	these	PRON
fnp-4366	88	19	with	with	ADP
fnp-4366	88	20	symptom	symptom	NOUN
fnp-4366	88	21	severity	severity	NOUN
fnp-4366	88	22	and	and	CCONJ
fnp-4366	88	23	impairment	impairment	NOUN
fnp-4366	88	24	.	.	PUNCT
fnp-4366	89	1	hypotheses	hypothesis	NOUN
fnp-4366	89	2	:	:	PUNCT
fnp-4366	89	3	we	we	PRON
fnp-4366	89	4	hypothesized	hypothesize	VERB
fnp-4366	89	5	a	a	DET
fnp-4366	89	6	lower	low	ADJ
fnp-4366	89	7	retinal	retinal	ADJ
fnp-4366	89	8	thickness	thickness	NOUN
fnp-4366	89	9	in	in	ADP
fnp-4366	89	10	sps	sps	PROPN
fnp-4366	89	11	patients	patient	NOUN
fnp-4366	89	12	in	in	ADP
fnp-4366	89	13	comparison	comparison	NOUN
fnp-4366	89	14	to	to	ADP
fnp-4366	89	15	normal	normal	ADJ
fnp-4366	89	16	healthy	healthy	ADJ
fnp-4366	89	17	controls	control	NOUN
fnp-4366	89	18	and	and	CCONJ
fnp-4366	89	19	patients	patient	NOUN
fnp-4366	89	20	with	with	ADP
fnp-4366	89	21	diabetes	diabetes	NOUN
fnp-4366	89	22	and	and	CCONJ
fnp-4366	89	23	furthermore	furthermore	ADV
fnp-4366	89	24	correlations	correlation	NOUN
fnp-4366	89	25	between	between	ADP
fnp-4366	89	26	gad	gad	NOUN
fnp-4366	89	27	antibody	antibody	NOUN
fnp-4366	89	28	levels	level	NOUN
fnp-4366	89	29	and	and	CCONJ
fnp-4366	89	30	findings	finding	NOUN
fnp-4366	89	31	in	in	ADP
fnp-4366	89	32	retina	retina	NOUN
fnp-4366	89	33	layer	layer	NOUN
fnp-4366	89	34	thickness	thickness	NOUN
fnp-4366	89	35	and	and	CCONJ
fnp-4366	89	36	correlations	correlation	NOUN
fnp-4366	89	37	with	with	ADP
fnp-4366	89	38	severity	severity	NOUN
fnp-4366	89	39	of	of	ADP
fnp-4366	89	40	the	the	DET
fnp-4366	89	41	disease	disease	NOUN
fnp-4366	89	42	.	.	PUNCT
fnp-4366	90	1	methods	method	NOUN
fnp-4366	90	2	:	:	PUNCT
fnp-4366	90	3	24	24	NUM
fnp-4366	90	4	gad	gad	PROPN
fnp-4366	90	5	positive	positive	ADJ
fnp-4366	90	6	sps	sps	NOUN
fnp-4366	90	7	patients	patient	NOUN
fnp-4366	90	8	(	(	PUNCT
fnp-4366	90	9	17	17	NUM
fnp-4366	90	10	female	female	NOUN
fnp-4366	90	11	;	;	PUNCT
fnp-4366	90	12	7	7	NUM
fnp-4366	90	13	male	male	NOUN
fnp-4366	90	14	;	;	PUNCT
fnp-4366	90	15	aged	aged	ADJ
fnp-4366	90	16	53	53	NUM
fnp-4366	90	17	±7	±7	NOUN
fnp-4366	90	18	;	;	PUNCT
fnp-4366	90	19	9	9	NUM
fnp-4366	90	20	with	with	ADP
fnp-4366	90	21	diabetes	diabetes	NOUN
fnp-4366	90	22	)	)	PUNCT
fnp-4366	90	23	received	receive	VERB
fnp-4366	90	24	a	a	DET
fnp-4366	90	25	clinical	clinical	ADJ
fnp-4366	90	26	examination	examination	NOUN
fnp-4366	90	27	and	and	CCONJ
fnp-4366	90	28	optical	optical	ADJ
fnp-4366	90	29	coherence	coherence	NOUN
fnp-4366	90	30	tomography	tomography	NOUN
fnp-4366	90	31	(	(	PUNCT
fnp-4366	90	32	oct	oct	PROPN
fnp-4366	90	33	)	)	PUNCT
fnp-4366	90	34	for	for	ADP
fnp-4366	90	35	retina	retina	NOUN
fnp-4366	90	36	layer	layer	NOUN
fnp-4366	90	37	thickness	thickness	NOUN
fnp-4366	90	38	.	.	PUNCT
fnp-4366	91	1	blood	blood	NOUN
fnp-4366	91	2	was	be	AUX
fnp-4366	91	3	drawn	draw	VERB
fnp-4366	91	4	for	for	ADP
fnp-4366	91	5	autoantibody	autoantibody	ADJ
fnp-4366	91	6	detection	detection	NOUN
fnp-4366	91	7	.	.	PUNCT
fnp-4366	92	1	data	datum	NOUN
fnp-4366	92	2	were	be	AUX
fnp-4366	92	3	compared	compare	VERB
fnp-4366	92	4	to	to	ADP
fnp-4366	92	5	a	a	DET
fnp-4366	92	6	matched	match	VERB
fnp-4366	92	7	healthy	healthy	ADJ
fnp-4366	92	8	cohort	cohort	NOUN
fnp-4366	92	9	and	and	CCONJ
fnp-4366	92	10	a	a	DET
fnp-4366	92	11	matched	match	VERB
fnp-4366	92	12	patients	patient	NOUN
fnp-4366	92	13	group	group	NOUN
fnp-4366	92	14	with	with	ADP
fnp-4366	92	15	diabetes	diabetes	NOUN
fnp-4366	92	16	but	but	CCONJ
fnp-4366	92	17	no	no	DET
fnp-4366	92	18	diabetic	diabetic	ADJ
fnp-4366	92	19	polyneuropathy	polyneuropathy	NOUN
fnp-4366	92	20	.	.	PUNCT
fnp-4366	93	1	the	the	DET
fnp-4366	93	2	severity	severity	NOUN
fnp-4366	93	3	of	of	ADP
fnp-4366	93	4	sps	sps	NOUN
fnp-4366	93	5	symptoms	symptom	NOUN
fnp-4366	93	6	and	and	CCONJ
fnp-4366	93	7	impairment	impairment	NOUN
fnp-4366	93	8	was	be	AUX
fnp-4366	93	9	assessed	assess	VERB
fnp-4366	93	10	on	on	ADP
fnp-4366	93	11	the	the	DET
fnp-4366	93	12	basis	basis	NOUN
fnp-4366	93	13	of	of	ADP
fnp-4366	93	14	the	the	DET
fnp-4366	93	15	ability	ability	NOUN
fnp-4366	93	16	to	to	PART
fnp-4366	93	17	walk	walk	VERB
fnp-4366	93	18	:	:	PUNCT
fnp-4366	93	19	free	free	ADJ
fnp-4366	93	20	walking	walking	NOUN
fnp-4366	93	21	,	,	PUNCT
fnp-4366	93	22	use	use	NOUN
fnp-4366	93	23	of	of	ADP
fnp-4366	93	24	a	a	DET
fnp-4366	93	25	crutch	crutch	NOUN
fnp-4366	93	26	,	,	PUNCT
fnp-4366	93	27	use	use	NOUN
fnp-4366	93	28	of	of	ADP
fnp-4366	93	29	two	two	NUM
fnp-4366	93	30	crutches	crutch	NOUN
fnp-4366	93	31	,	,	PUNCT
fnp-4366	93	32	walking	walk	VERB
fnp-4366	93	33	on	on	ADP
fnp-4366	93	34	the	the	DET
fnp-4366	93	35	rollator	rollator	NOUN
fnp-4366	93	36	or	or	CCONJ
fnp-4366	93	37	sitting	sit	VERB
fnp-4366	93	38	in	in	ADP
fnp-4366	93	39	a	a	DET
fnp-4366	93	40	wheelchair	wheelchair	NOUN
fnp-4366	93	41	.	.	PUNCT
fnp-4366	94	1	results	result	NOUN
fnp-4366	94	2	:	:	PUNCT
fnp-4366	94	3	oct	oct	PROPN
fnp-4366	94	4	showed	show	VERB
fnp-4366	94	5	lower	low	ADJ
fnp-4366	94	6	retinal	retinal	ADJ
fnp-4366	94	7	thickness	thickness	NOUN
fnp-4366	94	8	in	in	ADP
fnp-4366	94	9	gcipl	gcipl	PROPN
fnp-4366	94	10	and	and	CCONJ
fnp-4366	94	11	lower	low	ADJ
fnp-4366	94	12	average	average	ADJ
fnp-4366	94	13	macular	macular	ADJ
fnp-4366	94	14	thickness	thickness	NOUN
fnp-4366	94	15	(	(	PUNCT
fnp-4366	94	16	amt	amt	PROPN
fnp-4366	94	17	)	)	PUNCT
fnp-4366	94	18	in	in	ADP
fnp-4366	94	19	the	the	DET
fnp-4366	94	20	sps	sps	NOUN
fnp-4366	94	21	patients	patient	NOUN
fnp-4366	94	22	(	(	PUNCT
fnp-4366	94	23	gcipl	gcipl	PROPN
fnp-4366	94	24	:	:	PUNCT
fnp-4366	94	25	73.34±5,3	73.34±5,3	NUM
fnp-4366	94	26	;	;	PUNCT
fnp-4366	94	27	amt	amt	PROPN
fnp-4366	94	28	:	:	PUNCT
fnp-4366	94	29	302.98	302.98	NUM
fnp-4366	94	30	±12,1	±12,1	NOUN
fnp-4366	94	31	)	)	PUNCT
fnp-4366	94	32	in	in	ADP
fnp-4366	94	33	comparison	comparison	NOUN
fnp-4366	94	34	to	to	ADP
fnp-4366	94	35	healthy	healthy	ADJ
fnp-4366	94	36	controls	control	NOUN
fnp-4366	94	37	(	(	PUNCT
fnp-4366	94	38	gcipl	gcipl	PROPN
fnp-4366	94	39	:	:	PUNCT
fnp-4366	94	40	76.01	76.01	NUM
fnp-4366	94	41	±	±	NUM
fnp-4366	94	42	4,2	4,2	NUM
fnp-4366	94	43	;	;	PUNCT
fnp-4366	94	44	amt	amt	PROPN
fnp-4366	94	45	:	:	PUNCT
fnp-4366	94	46	311.76±13,4	311.76±13,4	NUM
fnp-4366	94	47	)	)	PUNCT
fnp-4366	94	48	.	.	PUNCT
fnp-4366	95	1	comparison	comparison	NOUN
fnp-4366	95	2	of	of	ADP
fnp-4366	95	3	the	the	DET
fnp-4366	95	4	15	15	NUM
fnp-4366	95	5	sps	sps	NOUN
fnp-4366	95	6	patients	patient	NOUN
fnp-4366	95	7	without	without	ADP
fnp-4366	95	8	diabetes	diabetes	NOUN
fnp-4366	95	9	with	with	ADP
fnp-4366	95	10	the	the	DET
fnp-4366	95	11	total	total	ADJ
fnp-4366	95	12	number	number	NOUN
fnp-4366	95	13	of	of	ADP
fnp-4366	95	14	25	25	NUM
fnp-4366	95	15	sps	sps	NOUN
fnp-4366	95	16	patients	patient	NOUN
fnp-4366	95	17	showed	show	VERB
fnp-4366	95	18	no	no	DET
fnp-4366	95	19	difference	difference	NOUN
fnp-4366	95	20	between	between	ADP
fnp-4366	95	21	these	these	DET
fnp-4366	95	22	results	result	NOUN
fnp-4366	95	23	.	.	PUNCT
fnp-4366	96	1	the	the	DET
fnp-4366	96	2	control	control	NOUN
fnp-4366	96	3	patients	patient	NOUN
fnp-4366	96	4	with	with	ADP
fnp-4366	96	5	only	only	ADJ
fnp-4366	96	6	diabetes	diabetes	NOUN
fnp-4366	96	7	had	have	VERB
fnp-4366	96	8	no	no	DET
fnp-4366	96	9	abnormalities	abnormality	NOUN
fnp-4366	96	10	in	in	ADP
fnp-4366	96	11	the	the	DET
fnp-4366	96	12	oct	oct	NOUN
fnp-4366	96	13	results	result	NOUN
fnp-4366	96	14	compared	compare	VERB
fnp-4366	96	15	to	to	ADP
fnp-4366	96	16	the	the	DET
fnp-4366	96	17	healthy	healthy	ADJ
fnp-4366	96	18	controls	control	NOUN
fnp-4366	96	19	,	,	PUNCT
fnp-4366	96	20	indicating	indicate	VERB
fnp-4366	96	21	that	that	SCONJ
fnp-4366	96	22	the	the	DET
fnp-4366	96	23	atrophy	atrophy	NOUN
fnp-4366	96	24	of	of	ADP
fnp-4366	96	25	gcipl	gcipl	PROPN
fnp-4366	96	26	and	and	CCONJ
fnp-4366	96	27	aml	aml	PROPN
fnp-4366	96	28	is	be	AUX
fnp-4366	96	29	likely	likely	ADJ
fnp-4366	96	30	to	to	PART
fnp-4366	96	31	be	be	AUX
fnp-4366	96	32	caused	cause	VERB
fnp-4366	96	33	exclusively	exclusively	ADV
fnp-4366	96	34	by	by	ADP
fnp-4366	96	35	the	the	DET
fnp-4366	96	36	sps	sps	NOUN
fnp-4366	96	37	and	and	CCONJ
fnp-4366	96	38	not	not	PART
fnp-4366	96	39	by	by	ADP
fnp-4366	96	40	diabetes	diabete	NOUN
fnp-4366	96	41	.	.	PUNCT
fnp-4366	97	1	there	there	PRON
fnp-4366	97	2	was	be	VERB
fnp-4366	97	3	a	a	DET
fnp-4366	97	4	positive	positive	ADJ
fnp-4366	97	5	correlation	correlation	NOUN
fnp-4366	97	6	between	between	ADP
fnp-4366	97	7	walking	walk	VERB
fnp-4366	97	8	ability	ability	NOUN
fnp-4366	97	9	and	and	CCONJ
fnp-4366	97	10	gcipl	gcipl	PROPN
fnp-4366	97	11	thickness	thickness	NOUN
fnp-4366	97	12	in	in	ADP
fnp-4366	97	13	sps	sps	PROPN
fnp-4366	97	14	patients	patient	NOUN
fnp-4366	97	15	;	;	PUNCT
fnp-4366	97	16	higher	high	ADJ
fnp-4366	97	17	gcipl	gcipl	PROPN
fnp-4366	97	18	thickness	thickness	NOUN
fnp-4366	97	19	was	be	AUX
fnp-4366	97	20	associated	associate	VERB
fnp-4366	97	21	with	with	ADP
fnp-4366	97	22	better	well	ADJ
fnp-4366	97	23	walking	walking	NOUN
fnp-4366	97	24	ability	ability	NOUN
fnp-4366	97	25	(	(	PUNCT
fnp-4366	97	26	r²	r²	NOUN
fnp-4366	97	27	=	=	SYM
fnp-4366	97	28	0,92	0,92	NUM
fnp-4366	97	29	)	)	PUNCT
fnp-4366	97	30	.	.	PUNCT
fnp-4366	98	1	conclusion	conclusion	NOUN
fnp-4366	98	2	:	:	PUNCT
fnp-4366	98	3	this	this	DET
fnp-4366	98	4	study	study	NOUN
fnp-4366	98	5	indicates	indicate	VERB
fnp-4366	98	6	retinal	retinal	ADJ
fnp-4366	98	7	involvement	involvement	NOUN
fnp-4366	98	8	in	in	ADP
fnp-4366	98	9	sps	sps	PROPN
fnp-4366	98	10	.	.	PUNCT
fnp-4366	99	1	oct	oct	PROPN
fnp-4366	99	2	might	might	AUX
fnp-4366	99	3	be	be	AUX
fnp-4366	99	4	useful	useful	ADJ
fnp-4366	99	5	as	as	ADP
fnp-4366	99	6	a	a	DET
fnp-4366	99	7	complementary	complementary	ADJ
fnp-4366	99	8	diagnostic	diagnostic	ADJ
fnp-4366	99	9	tool	tool	NOUN
fnp-4366	99	10	in	in	ADP
fnp-4366	99	11	sps	sps	PROPN
fnp-4366	99	12	,	,	PUNCT
fnp-4366	99	13	and	and	CCONJ
fnp-4366	99	14	retinal	retinal	ADJ
fnp-4366	99	15	layer	layer	NOUN
fnp-4366	99	16	thickness	thickness	NOUN
fnp-4366	99	17	measurements	measurement	NOUN
fnp-4366	99	18	might	might	AUX
fnp-4366	99	19	be	be	AUX
fnp-4366	99	20	developed	develop	VERB
fnp-4366	99	21	as	as	ADP
fnp-4366	99	22	a	a	DET
fnp-4366	99	23	non	non	ADJ
fnp-4366	99	24	-	-	ADJ
fnp-4366	99	25	invasive	invasive	ADJ
fnp-4366	99	26	biomarker	biomarker	NOUN
fnp-4366	99	27	for	for	ADP
fnp-4366	99	28	disease	disease	NOUN
fnp-4366	99	29	progression	progression	NOUN
fnp-4366	99	30	.	.	PUNCT
fnp-4366	99	31	  	  	SPACE
fnp-4366	99	32	1.06	1.06	NUM
fnp-4366	99	33	free	free	ADJ
fnp-4366	99	34	neuropathol	neuropathol	NOUN
fnp-4366	99	35	3:20:12	3:20:12	NUM
fnp-4366	99	36	deep	deep	ADJ
fnp-4366	99	37	learning	learning	NOUN
fnp-4366	99	38	based	base	VERB
fnp-4366	99	39	cerebrospinal	cerebrospinal	ADJ
fnp-4366	99	40	fluid	fluid	ADJ
fnp-4366	99	41	diagnostics	diagnostic	NOUN
fnp-4366	99	42	leonille	leonille	NOUN
fnp-4366	99	43	schweizer1,2	schweizer1,2	PROPN
fnp-4366	99	44	,	,	PUNCT
fnp-4366	99	45	philipp	philipp	PROPN
fnp-4366	99	46	seegerer3	seegerer3	PROPN
fnp-4366	99	47	,	,	PUNCT
fnp-4366	99	48	hee	hee	PROPN
fnp-4366	99	49	-	-	PROPN
fnp-4366	99	50	yeong	yeong	PROPN
fnp-4366	99	51	kim4	kim4	PROPN
fnp-4366	99	52	,	,	PUNCT
fnp-4366	99	53	rené	rené	PROPN
fnp-4366	99	54	saitenmacher3	saitenmacher3	PROPN
fnp-4366	99	55	,	,	PUNCT
fnp-4366	99	56	amos	amos	PROPN
fnp-4366	99	57	münch1	münch1	PROPN
fnp-4366	99	58	,	,	PUNCT
fnp-4366	99	59	liane	liane	PROPN
fnp-4366	99	60	barnick1	barnick1	PROPN
fnp-4366	99	61	,	,	PUNCT
fnp-4366	99	62	anja	anja	PROPN
fnp-4366	99	63	osterloh1	osterloh1	PROPN
fnp-4366	99	64	,	,	PUNCT
fnp-4366	99	65	carsten	carsten	PROPN
fnp-4366	99	66	dittmayer1	dittmayer1	PROPN
fnp-4366	99	67	,	,	PUNCT
fnp-4366	99	68	ruben	ruben	PROPN
fnp-4366	99	69	jödicke1	jödicke1	PROPN
fnp-4366	99	70	,	,	PUNCT
fnp-4366	99	71	debora	debora	PROPN
fnp-4366	99	72	pehl1	pehl1	PROPN
fnp-4366	99	73	,	,	PUNCT
fnp-4366	99	74	annekathrin	annekathrin	PROPN
fnp-4366	99	75	reinhardt5	reinhardt5	PROPN
fnp-4366	99	76	,	,	PUNCT
fnp-4366	99	77	klemens	klemen	VERB
fnp-4366	99	78	ruprecht6	ruprecht6	PROPN
fnp-4366	99	79	,	,	PUNCT
fnp-4366	99	80	annika	annika	PROPN
fnp-4366	99	81	k	k	PROPN
fnp-4366	99	82	wefers7	wefers7	PROPN
fnp-4366	99	83	,	,	PUNCT
fnp-4366	99	84	patrick	patrick	PROPN
fnp-4366	99	85	harter8	harter8	PROPN
fnp-4366	99	86	,	,	PUNCT
fnp-4366	99	87	ulrich	ulrich	PROPN
fnp-4366	99	88	schüller7	schüller7	NOUN
fnp-4366	99	89	,	,	PUNCT
fnp-4366	99	90	frank	frank	PROPN
fnp-4366	99	91	l	l	PROPN
fnp-4366	99	92	heppner1	heppner1	PROPN
fnp-4366	99	93	,	,	PUNCT
fnp-4366	99	94	maximilian	maximilian	PROPN
fnp-4366	99	95	alber3	alber3	PROPN
fnp-4366	99	96	,	,	PUNCT
fnp-4366	99	97	klaus	klaus	PROPN
fnp-4366	99	98	-	-	PUNCT
fnp-4366	99	99	robert	robert	PROPN
fnp-4366	99	100	müller3	müller3	PROPN
fnp-4366	99	101	,	,	PUNCT
fnp-4366	99	102	frederick	frederick	PROPN
fnp-4366	99	103	klauschen9	klauschen9	PROPN
fnp-4366	99	104	1	1	NUM
fnp-4366	99	105	institute	institute	PROPN
fnp-4366	99	106	of	of	ADP
fnp-4366	99	107	neuropathology	neuropathology	NOUN
fnp-4366	99	108	,	,	PUNCT
fnp-4366	99	109	charité	charité	PROPN
fnp-4366	99	110	–	–	PUNCT
fnp-4366	99	111	universitätsmedizin	universitätsmedizin	PROPN
fnp-4366	99	112	berlin	berlin	PROPN
fnp-4366	99	113	,	,	PUNCT
fnp-4366	99	114	corporate	corporate	ADJ
fnp-4366	99	115	member	member	NOUN
fnp-4366	99	116	of	of	ADP
fnp-4366	99	117	freie	freie	PROPN
fnp-4366	99	118	universität	universität	PROPN
fnp-4366	99	119	berlin	berlin	PROPN
fnp-4366	99	120	,	,	PUNCT
fnp-4366	99	121	humboldt	humboldt	PROPN
fnp-4366	99	122	-	-	PUNCT
fnp-4366	99	123	universität	universität	PROPN
fnp-4366	99	124	zu	zu	PROPN
fnp-4366	99	125	berlin	berlin	PROPN
fnp-4366	99	126	and	and	CCONJ
fnp-4366	99	127	berlin	berlin	PROPN
fnp-4366	99	128	institute	institute	PROPN
fnp-4366	99	129	of	of	ADP
fnp-4366	99	130	health	health	PROPN
fnp-4366	99	131	,	,	PUNCT
fnp-4366	99	132	berlin	berlin	PROPN
fnp-4366	99	133	,	,	PUNCT
fnp-4366	99	134	berlin	berlin	PROPN
fnp-4366	99	135	,	,	PUNCT
fnp-4366	99	136	deutschland	deutschland	NOUN
fnp-4366	99	137	2	2	NUM
fnp-4366	99	138	german	german	ADJ
fnp-4366	99	139	cancer	cancer	NOUN
fnp-4366	99	140	consortium	consortium	NOUN
fnp-4366	99	141	(	(	PUNCT
fnp-4366	99	142	dktk	dktk	NOUN
fnp-4366	99	143	)	)	PUNCT
fnp-4366	99	144	,	,	PUNCT
fnp-4366	99	145	partner	partner	NOUN
fnp-4366	99	146	site	site	NOUN
fnp-4366	99	147	berlin	berlin	PROPN
fnp-4366	99	148	,	,	PUNCT
fnp-4366	99	149	and	and	CCONJ
fnp-4366	99	150	german	german	ADJ
fnp-4366	99	151	cancer	cancer	NOUN
fnp-4366	99	152	research	research	NOUN
fnp-4366	99	153	center	center	NOUN
fnp-4366	99	154	(	(	PUNCT
fnp-4366	99	155	dkfz	dkfz	PROPN
fnp-4366	99	156	)	)	PUNCT
fnp-4366	99	157	,	,	PUNCT
fnp-4366	99	158	berlin	berlin	PROPN
fnp-4366	99	159	,	,	PUNCT
fnp-4366	99	160	deutschland	deutschland	NOUN
fnp-4366	99	161	3	3	NUM
fnp-4366	99	162	machine	machine	NOUN
fnp-4366	99	163	-	-	PUNCT
fnp-4366	99	164	learning	learn	VERB
fnp-4366	99	165	group	group	NOUN
fnp-4366	99	166	,	,	PUNCT
fnp-4366	99	167	department	department	NOUN
fnp-4366	99	168	of	of	ADP
fnp-4366	99	169	software	software	NOUN
fnp-4366	99	170	engineering	engineering	NOUN
fnp-4366	99	171	and	and	CCONJ
fnp-4366	99	172	theoretical	theoretical	ADJ
fnp-4366	99	173	computer	computer	NOUN
fnp-4366	99	174	science	science	NOUN
fnp-4366	99	175	,	,	PUNCT
fnp-4366	99	176	technical	technical	ADJ
fnp-4366	99	177	university	university	PROPN
fnp-4366	99	178	of	of	ADP
fnp-4366	99	179	berlin	berlin	PROPN
fnp-4366	99	180	,	,	PUNCT
fnp-4366	99	181	berlin	berlin	PROPN
fnp-4366	99	182	,	,	PUNCT
fnp-4366	99	183	deutschland	deutschland	NOUN
fnp-4366	99	184	4	4	NUM
fnp-4366	99	185	systems	system	NOUN
fnp-4366	99	186	medicine	medicine	NOUN
fnp-4366	99	187	of	of	ADP
fnp-4366	99	188	infectious	infectious	ADJ
fnp-4366	99	189	disease	disease	NOUN
fnp-4366	99	190	,	,	PUNCT
fnp-4366	99	191	robert	robert	PROPN
fnp-4366	99	192	koch	koch	PROPN
fnp-4366	99	193	institute	institute	PROPN
fnp-4366	99	194	,	,	PUNCT
fnp-4366	99	195	berlin	berlin	PROPN
fnp-4366	99	196	,	,	PUNCT
fnp-4366	99	197	deutschland	deutschland	NOUN
fnp-4366	99	198	5	5	NUM
fnp-4366	99	199	department	department	NOUN
fnp-4366	99	200	of	of	ADP
fnp-4366	99	201	neuropathology	neuropathology	NOUN
fnp-4366	99	202	,	,	PUNCT
fnp-4366	99	203	university	university	NOUN
fnp-4366	99	204	hospital	hospital	NOUN
fnp-4366	99	205	heidelberg	heidelberg	PROPN
fnp-4366	99	206	,	,	PUNCT
fnp-4366	99	207	heidelberg	heidelberg	PROPN
fnp-4366	99	208	,	,	PUNCT
fnp-4366	99	209	deutschland	deutschland	NOUN
fnp-4366	99	210	6	6	NUM
fnp-4366	99	211	department	department	NOUN
fnp-4366	99	212	of	of	ADP
fnp-4366	99	213	neurology	neurology	NOUN
fnp-4366	99	214	,	,	PUNCT
fnp-4366	99	215	charité	charité	PROPN
fnp-4366	99	216	university	university	PROPN
fnp-4366	99	217	medicine	medicine	PROPN
fnp-4366	99	218	berlin	berlin	PROPN
fnp-4366	99	219	,	,	PUNCT
fnp-4366	99	220	berlin	berlin	PROPN
fnp-4366	99	221	,	,	PUNCT
fnp-4366	99	222	deutschland	deutschland	PROPN
fnp-4366	99	223	7	7	NUM
fnp-4366	99	224	institute	institute	NOUN
fnp-4366	99	225	of	of	ADP
fnp-4366	99	226	neuropathology	neuropathology	NOUN
fnp-4366	99	227	,	,	PUNCT
fnp-4366	99	228	university	university	NOUN
fnp-4366	99	229	medical	medical	ADJ
fnp-4366	99	230	center	center	PROPN
fnp-4366	99	231	hamburg	hamburg	PROPN
fnp-4366	99	232	-	-	PUNCT
fnp-4366	99	233	eppendorf	eppendorf	PROPN
fnp-4366	99	234	,	,	PUNCT
fnp-4366	99	235	hamburg	hamburg	PROPN
fnp-4366	99	236	,	,	PUNCT
fnp-4366	99	237	deutschland	deutschland	NOUN
fnp-4366	99	238	8	8	NUM
fnp-4366	99	239	neurological	neurological	ADJ
fnp-4366	99	240	institute	institute	NOUN
fnp-4366	99	241	(	(	PUNCT
fnp-4366	99	242	edinger	edinger	PROPN
fnp-4366	99	243	institute	institute	PROPN
fnp-4366	99	244	)	)	PUNCT
fnp-4366	99	245	,	,	PUNCT
fnp-4366	99	246	goethe	goethe	PROPN
fnp-4366	99	247	university	university	PROPN
fnp-4366	99	248	,	,	PUNCT
fnp-4366	99	249	frankfurt	frankfurt	PROPN
fnp-4366	99	250	,	,	PUNCT
fnp-4366	99	251	deutschland	deutschland	PROPN
fnp-4366	99	252	9	9	NUM
fnp-4366	99	253	institute	institute	NOUN
fnp-4366	99	254	of	of	ADP
fnp-4366	99	255	pathology	pathology	PROPN
fnp-4366	99	256	,	,	PUNCT
fnp-4366	99	257	ludwig	ludwig	PROPN
fnp-4366	99	258	-	-	PUNCT
fnp-4366	99	259	maximilians	maximilians	PROPN
fnp-4366	99	260	-	-	PUNCT
fnp-4366	99	261	universität	universität	NOUN
fnp-4366	99	262	münchen	münchen	NOUN
fnp-4366	99	263	,	,	PUNCT
fnp-4366	99	264	münchen	münchen	NOUN
fnp-4366	99	265	,	,	PUNCT
fnp-4366	99	266	deutschland	deutschland	NOUN
fnp-4366	99	267	background	background	NOUN
fnp-4366	99	268	:	:	PUNCT
fnp-4366	99	269	the	the	DET
fnp-4366	99	270	analysis	analysis	NOUN
fnp-4366	99	271	of	of	ADP
fnp-4366	99	272	cerebrospinal	cerebrospinal	ADJ
fnp-4366	99	273	fluid	fluid	NOUN
fnp-4366	99	274	(	(	PUNCT
fnp-4366	99	275	csf	csf	NOUN
fnp-4366	99	276	)	)	PUNCT
fnp-4366	99	277	specimens	specimen	NOUN
fnp-4366	99	278	is	be	AUX
fnp-4366	99	279	essential	essential	ADJ
fnp-4366	99	280	for	for	ADP
fnp-4366	99	281	the	the	DET
fnp-4366	99	282	diagnostic	diagnostic	ADJ
fnp-4366	99	283	workup	workup	NOUN
fnp-4366	99	284	and	and	CCONJ
fnp-4366	99	285	clinical	clinical	ADJ
fnp-4366	99	286	management	management	NOUN
fnp-4366	99	287	of	of	ADP
fnp-4366	99	288	neurological	neurological	ADJ
fnp-4366	99	289	patients	patient	NOUN
fnp-4366	99	290	and	and	CCONJ
fnp-4366	99	291	relies	rely	VERB
fnp-4366	99	292	on	on	ADP
fnp-4366	99	293	differential	differential	ADJ
fnp-4366	99	294	cell	cell	NOUN
fnp-4366	99	295	typing	typing	NOUN
fnp-4366	99	296	.	.	PUNCT
fnp-4366	100	1	because	because	SCONJ
fnp-4366	100	2	blood	blood	NOUN
fnp-4366	100	3	cell	cell	NOUN
fnp-4366	100	4	cytometers	cytometer	NOUN
fnp-4366	100	5	are	be	AUX
fnp-4366	100	6	unable	unable	ADJ
fnp-4366	100	7	to	to	PART
fnp-4366	100	8	identify	identify	VERB
fnp-4366	100	9	diagnostically	diagnostically	ADV
fnp-4366	100	10	relevant	relevant	ADJ
fnp-4366	100	11	cell	cell	NOUN
fnp-4366	100	12	types	type	NOUN
fnp-4366	100	13	in	in	ADP
fnp-4366	100	14	csf	csf	ADJ
fnp-4366	100	15	samples	sample	NOUN
fnp-4366	100	16	,	,	PUNCT
fnp-4366	100	17	the	the	DET
fnp-4366	100	18	current	current	ADJ
fnp-4366	100	19	gold	gold	NOUN
fnp-4366	100	20	-	-	PUNCT
fnp-4366	100	21	standard	standard	NOUN
fnp-4366	100	22	is	be	AUX
fnp-4366	100	23	based	base	VERB
fnp-4366	100	24	on	on	ADP
fnp-4366	100	25	microscopic	microscopic	ADJ
fnp-4366	100	26	examination	examination	NOUN
fnp-4366	100	27	by	by	ADP
fnp-4366	100	28	specialized	specialized	ADJ
fnp-4366	100	29	technicians	technician	NOUN
fnp-4366	100	30	and	and	CCONJ
fnp-4366	100	31	neuropathologists	neuropathologist	NOUN
fnp-4366	100	32	.	.	PUNCT
fnp-4366	101	1	manual	manual	ADJ
fnp-4366	101	2	differential	differential	ADJ
fnp-4366	101	3	cell	cell	NOUN
fnp-4366	101	4	count	count	NOUN
fnp-4366	101	5	is	be	AUX
fnp-4366	101	6	time	time	NOUN
fnp-4366	101	7	-	-	PUNCT
fnp-4366	101	8	consuming	consume	VERB
fnp-4366	101	9	,	,	PUNCT
fnp-4366	101	10	labor	labor	NOUN
fnp-4366	101	11	-	-	PUNCT
fnp-4366	101	12	intensive	intensive	ADJ
fnp-4366	101	13	and	and	CCONJ
fnp-4366	101	14	subjective	subjective	ADJ
fnp-4366	101	15	.	.	PUNCT
fnp-4366	102	1	we	we	PRON
fnp-4366	102	2	therefore	therefore	ADV
fnp-4366	102	3	set	set	VERB
fnp-4366	102	4	out	out	ADP
fnp-4366	102	5	to	to	PART
fnp-4366	102	6	compile	compile	VERB
fnp-4366	102	7	a	a	DET
fnp-4366	102	8	real	real	ADJ
fnp-4366	102	9	-	-	PUNCT
fnp-4366	102	10	world	world	NOUN
fnp-4366	102	11	csf	csf	ADJ
fnp-4366	102	12	dataset	dataset	NOUN
fnp-4366	102	13	including	include	VERB
fnp-4366	102	14	all	all	DET
fnp-4366	102	15	diagnostically	diagnostically	ADV
fnp-4366	102	16	relevant	relevant	ADJ
fnp-4366	102	17	cell	cell	NOUN
fnp-4366	102	18	types	type	NOUN
fnp-4366	102	19	to	to	PART
fnp-4366	102	20	train	train	VERB
fnp-4366	102	21	a	a	DET
fnp-4366	102	22	robust	robust	ADJ
fnp-4366	102	23	algorithm	algorithm	NOUN
fnp-4366	102	24	for	for	ADP
fnp-4366	102	25	cell	cell	NOUN
fnp-4366	102	26	type	type	NOUN
fnp-4366	102	27	differentiation	differentiation	NOUN
fnp-4366	102	28	with	with	ADP
fnp-4366	102	29	the	the	DET
fnp-4366	102	30	potential	potential	NOUN
fnp-4366	102	31	to	to	PART
fnp-4366	102	32	solve	solve	VERB
fnp-4366	102	33	complex	complex	ADJ
fnp-4366	102	34	diagnostic	diagnostic	ADJ
fnp-4366	102	35	tasks	task	NOUN
fnp-4366	102	36	.	.	PUNCT
fnp-4366	103	1	methods	method	NOUN
fnp-4366	103	2	:	:	PUNCT
fnp-4366	103	3	we	we	PRON
fnp-4366	103	4	therefore	therefore	ADV
fnp-4366	103	5	developed	develop	VERB
fnp-4366	103	6	an	an	DET
fnp-4366	103	7	image	image	NOUN
fnp-4366	103	8	analysis	analysis	NOUN
fnp-4366	103	9	approach	approach	NOUN
fnp-4366	103	10	based	base	VERB
fnp-4366	103	11	on	on	ADP
fnp-4366	103	12	expert	expert	ADJ
fnp-4366	103	13	annotations	annotation	NOUN
fnp-4366	103	14	of	of	ADP
fnp-4366	103	15	127.455	127.455	NUM
fnp-4366	103	16	digitized	digitize	VERB
fnp-4366	103	17	csf	csf	ADJ
fnp-4366	103	18	objects	object	NOUN
fnp-4366	103	19	from	from	ADP
fnp-4366	103	20	78	78	NUM
fnp-4366	103	21	patients	patient	NOUN
fnp-4366	103	22	corresponding	correspond	VERB
fnp-4366	103	23	to	to	ADP
fnp-4366	103	24	15	15	NUM
fnp-4366	103	25	clinically	clinically	ADV
fnp-4366	103	26	relevant	relevant	ADJ
fnp-4366	103	27	categories	category	NOUN
fnp-4366	103	28	and	and	CCONJ
fnp-4366	103	29	trained	train	VERB
fnp-4366	103	30	a	a	DET
fnp-4366	103	31	multiclass	multiclass	ADJ
fnp-4366	103	32	convolutional	convolutional	ADJ
fnp-4366	103	33	neural	neural	ADJ
fnp-4366	103	34	network	network	NOUN
fnp-4366	103	35	(	(	PUNCT
fnp-4366	103	36	cnn	cnn	PROPN
fnp-4366	103	37	)	)	PUNCT
fnp-4366	103	38	.	.	PUNCT
fnp-4366	104	1	we	we	PRON
fnp-4366	104	2	applied	apply	VERB
fnp-4366	104	3	explainable	explainable	ADJ
fnp-4366	104	4	artificial	artificial	ADJ
fnp-4366	104	5	intelligence	intelligence	NOUN
fnp-4366	104	6	(	(	PUNCT
fnp-4366	104	7	xai	xai	PROPN
fnp-4366	104	8	)	)	PUNCT
fnp-4366	104	9	methods	method	NOUN
fnp-4366	104	10	to	to	PART
fnp-4366	104	11	elucidate	elucidate	VERB
fnp-4366	104	12	the	the	DET
fnp-4366	104	13	most	most	ADV
fnp-4366	104	14	relevant	relevant	ADJ
fnp-4366	104	15	image	image	NOUN
fnp-4366	104	16	pixels	pixel	NOUN
fnp-4366	104	17	for	for	ADP
fnp-4366	104	18	cnn	cnn	PROPN
fnp-4366	104	19	predictions	prediction	NOUN
fnp-4366	104	20	and	and	CCONJ
fnp-4366	104	21	compare	compare	NOUN
fnp-4366	104	22	pattern	pattern	NOUN
fnp-4366	104	23	recognition	recognition	NOUN
fnp-4366	104	24	to	to	ADP
fnp-4366	104	25	humans	human	NOUN
fnp-4366	104	26	.	.	PUNCT
fnp-4366	105	1	we	we	PRON
fnp-4366	105	2	further	far	ADV
fnp-4366	105	3	developed	develop	VERB
fnp-4366	105	4	a	a	DET
fnp-4366	105	5	new	new	ADJ
fnp-4366	105	6	data	datum	NOUN
fnp-4366	105	7	partitioning	partition	VERB
fnp-4366	105	8	strategy	strategy	NOUN
fnp-4366	105	9	for	for	ADP
fnp-4366	105	10	further	further	ADJ
fnp-4366	105	11	machine	machine	NOUN
fnp-4366	105	12	learning	learning	NOUN
fnp-4366	105	13	projects	project	NOUN
fnp-4366	105	14	.	.	PUNCT
fnp-4366	106	1	to	to	PART
fnp-4366	106	2	assess	assess	VERB
fnp-4366	106	3	the	the	DET
fnp-4366	106	4	realistic	realistic	ADJ
fnp-4366	106	5	usefulness	usefulness	NOUN
fnp-4366	106	6	in	in	ADP
fnp-4366	106	7	diagnostic	diagnostic	ADJ
fnp-4366	106	8	practice	practice	NOUN
fnp-4366	106	9	,	,	PUNCT
fnp-4366	106	10	we	we	PRON
fnp-4366	106	11	validated	validate	VERB
fnp-4366	106	12	the	the	DET
fnp-4366	106	13	cnn	cnn	PROPN
fnp-4366	106	14	-	-	PUNCT
fnp-4366	106	15	based	base	VERB
fnp-4366	106	16	approach	approach	NOUN
fnp-4366	106	17	by	by	ADP
fnp-4366	106	18	comparing	compare	VERB
fnp-4366	106	19	its	its	PRON
fnp-4366	106	20	performance	performance	NOUN
fnp-4366	106	21	to	to	ADP
fnp-4366	106	22	that	that	PRON
fnp-4366	106	23	of	of	ADP
fnp-4366	106	24	seven	seven	NUM
fnp-4366	106	25	board	board	NOUN
fnp-4366	106	26	certified	certify	VERB
fnp-4366	106	27	neuropathologist	neuropathologist	NOUN
fnp-4366	106	28	from	from	ADP
fnp-4366	106	29	different	different	ADJ
fnp-4366	106	30	academic	academic	ADJ
fnp-4366	106	31	institutions	institution	NOUN
fnp-4366	106	32	.	.	PUNCT
fnp-4366	107	1	results	result	NOUN
fnp-4366	107	2	:	:	PUNCT
fnp-4366	107	3	the	the	DET
fnp-4366	107	4	cnn	cnn	PROPN
fnp-4366	107	5	classified	classify	VERB
fnp-4366	107	6	the	the	DET
fnp-4366	107	7	15	15	NUM
fnp-4366	107	8	categories	category	NOUN
fnp-4366	107	9	with	with	ADP
fnp-4366	107	10	high	high	ADJ
fnp-4366	107	11	accuracy	accuracy	NOUN
fnp-4366	107	12	(	(	PUNCT
fnp-4366	107	13	mean	mean	INTJ
fnp-4366	107	14	auc	auc	NOUN
fnp-4366	107	15	97.3	97.3	NUM
fnp-4366	107	16	%	%	NOUN
fnp-4366	107	17	)	)	PUNCT
fnp-4366	107	18	.	.	PUNCT
fnp-4366	108	1	by	by	ADP
fnp-4366	108	2	using	use	VERB
fnp-4366	108	3	xai	xai	PROPN
fnp-4366	108	4	,	,	PUNCT
fnp-4366	108	5	we	we	PRON
fnp-4366	108	6	could	could	AUX
fnp-4366	108	7	demonstrate	demonstrate	VERB
fnp-4366	108	8	that	that	SCONJ
fnp-4366	108	9	the	the	DET
fnp-4366	108	10	cnn	cnn	PROPN
fnp-4366	108	11	identified	identify	VERB
fnp-4366	108	12	meaningful	meaningful	ADJ
fnp-4366	108	13	substructures	substructure	NOUN
fnp-4366	108	14	in	in	ADP
fnp-4366	108	15	csf	csf	ADJ
fnp-4366	108	16	cells	cell	NOUN
fnp-4366	108	17	recapitulating	recapitulate	VERB
fnp-4366	108	18	human	human	ADJ
fnp-4366	108	19	pattern	pattern	NOUN
fnp-4366	108	20	recognition	recognition	NOUN
fnp-4366	108	21	.	.	PUNCT
fnp-4366	109	1	we	we	PRON
fnp-4366	109	2	validated	validate	VERB
fnp-4366	109	3	the	the	DET
fnp-4366	109	4	diagnostic	diagnostic	ADJ
fnp-4366	109	5	performance	performance	NOUN
fnp-4366	109	6	of	of	ADP
fnp-4366	109	7	the	the	DET
fnp-4366	109	8	cnn	cnn	PROPN
fnp-4366	109	9	by	by	ADP
fnp-4366	109	10	comparing	compare	VERB
fnp-4366	109	11	the	the	DET
fnp-4366	109	12	predictions	prediction	NOUN
fnp-4366	109	13	of	of	ADP
fnp-4366	109	14	511	511	NUM
fnp-4366	109	15	cells	cell	NOUN
fnp-4366	109	16	selected	select	VERB
fnp-4366	109	17	from	from	ADP
fnp-4366	109	18	12	12	NUM
fnp-4366	109	19	different	different	ADJ
fnp-4366	109	20	csf	csf	ADJ
fnp-4366	109	21	samples	sample	NOUN
fnp-4366	109	22	to	to	ADP
fnp-4366	109	23	seven	seven	NUM
fnp-4366	109	24	board	board	NOUN
fnp-4366	109	25	-	-	PUNCT
fnp-4366	109	26	certified	certify	VERB
fnp-4366	109	27	neuropathologists	neuropathologist	NOUN
fnp-4366	109	28	blinded	blind	VERB
fnp-4366	109	29	for	for	ADP
fnp-4366	109	30	clinical	clinical	ADJ
fnp-4366	109	31	information	information	NOUN
fnp-4366	109	32	.	.	PUNCT
fnp-4366	110	1	inter	inter	ADJ
fnp-4366	110	2	-	-	ADJ
fnp-4366	110	3	rater	rater	ADJ
fnp-4366	110	4	agreement	agreement	NOUN
fnp-4366	110	5	between	between	ADP
fnp-4366	110	6	the	the	DET
fnp-4366	110	7	cnn	cnn	PROPN
fnp-4366	110	8	and	and	CCONJ
fnp-4366	110	9	the	the	DET
fnp-4366	110	10	ground	ground	NOUN
fnp-4366	110	11	truth	truth	NOUN
fnp-4366	110	12	was	be	AUX
fnp-4366	110	13	non	non	ADJ
fnp-4366	110	14	-	-	ADJ
fnp-4366	110	15	inferior	inferior	ADJ
fnp-4366	110	16	(	(	PUNCT
fnp-4366	110	17	krippendorff	krippendorff	PROPN
fnp-4366	110	18	’s	’s	PART
fnp-4366	110	19	alpha	alpha	NOUN
fnp-4366	110	20	0.79	0.79	NUM
fnp-4366	110	21	)	)	PUNCT
fnp-4366	110	22	compared	compare	VERB
fnp-4366	110	23	to	to	ADP
fnp-4366	110	24	the	the	DET
fnp-4366	110	25	agreement	agreement	NOUN
fnp-4366	110	26	of	of	ADP
fnp-4366	110	27	seven	seven	NUM
fnp-4366	110	28	human	human	ADJ
fnp-4366	110	29	raters	rater	NOUN
fnp-4366	110	30	and	and	CCONJ
fnp-4366	110	31	the	the	DET
fnp-4366	110	32	ground	ground	NOUN
fnp-4366	110	33	truth	truth	NOUN
fnp-4366	110	34	(	(	PUNCT
fnp-4366	110	35	mean	mean	PROPN
fnp-4366	110	36	krippendorff	krippendorff	PROPN
fnp-4366	110	37	’s	’s	PART
fnp-4366	110	38	alpha	alpha	NOUN
fnp-4366	110	39	0.72	0.72	NUM
fnp-4366	110	40	,	,	PUNCT
fnp-4366	110	41	range	range	VERB
fnp-4366	110	42	0.56	0.56	NUM
fnp-4366	110	43	-	-	SYM
fnp-4366	110	44	0.81	0.81	NUM
fnp-4366	110	45	)	)	PUNCT
fnp-4366	110	46	.	.	PUNCT
fnp-4366	111	1	the	the	DET
fnp-4366	111	2	cnn	cnn	PROPN
fnp-4366	111	3	assigned	assign	VERB
fnp-4366	111	4	the	the	DET
fnp-4366	111	5	correct	correct	ADJ
fnp-4366	111	6	diagnostic	diagnostic	ADJ
fnp-4366	111	7	label	label	NOUN
fnp-4366	111	8	(	(	PUNCT
fnp-4366	111	9	inflammatory	inflammatory	ADJ
fnp-4366	111	10	,	,	PUNCT
fnp-4366	111	11	hemorrhagic	hemorrhagic	ADJ
fnp-4366	111	12	or	or	CCONJ
fnp-4366	111	13	neoplastic	neoplastic	ADJ
fnp-4366	111	14	)	)	PUNCT
fnp-4366	111	15	in	in	ADP
fnp-4366	111	16	10	10	NUM
fnp-4366	111	17	out	out	ADP
fnp-4366	111	18	of	of	ADP
fnp-4366	111	19	11	11	NUM
fnp-4366	111	20	clinical	clinical	ADJ
fnp-4366	111	21	samples	sample	NOUN
fnp-4366	111	22	compared	compare	VERB
fnp-4366	111	23	to	to	ADP
fnp-4366	111	24	7	7	NUM
fnp-4366	111	25	-	-	SYM
fnp-4366	111	26	11	11	NUM
fnp-4366	111	27	out	out	ADP
fnp-4366	111	28	of	of	ADP
fnp-4366	111	29	11	11	NUM
fnp-4366	111	30	correctly	correctly	ADV
fnp-4366	111	31	labeled	label	VERB
fnp-4366	111	32	csfs	csfs	NOUN
fnp-4366	111	33	by	by	ADP
fnp-4366	111	34	human	human	ADJ
fnp-4366	111	35	raters	rater	NOUN
fnp-4366	111	36	.	.	PUNCT
fnp-4366	112	1	similar	similar	ADJ
fnp-4366	112	2	to	to	ADP
fnp-4366	112	3	four	four	NUM
fnp-4366	112	4	human	human	ADJ
fnp-4366	112	5	raters	rater	NOUN
fnp-4366	112	6	,	,	PUNCT
fnp-4366	112	7	the	the	DET
fnp-4366	112	8	cnn	cnn	PROPN
fnp-4366	112	9	misclassified	misclassifie	VERB
fnp-4366	112	10	single	single	ADJ
fnp-4366	112	11	highly	highly	ADV
fnp-4366	112	12	activated	activated	ADJ
fnp-4366	112	13	b	b	NOUN
fnp-4366	112	14	-	-	PUNCT
fnp-4366	112	15	cells	cell	NOUN
fnp-4366	112	16	as	as	ADP
fnp-4366	112	17	cancer	cancer	NOUN
fnp-4366	112	18	cells	cell	NOUN
fnp-4366	112	19	in	in	ADP
fnp-4366	112	20	two	two	NUM
fnp-4366	112	21	samples	sample	NOUN
fnp-4366	112	22	,	,	PUNCT
fnp-4366	112	23	but	but	CCONJ
fnp-4366	112	24	indicated	indicate	VERB
fnp-4366	112	25	reduced	reduced	ADJ
fnp-4366	112	26	confidence	confidence	NOUN
fnp-4366	112	27	by	by	ADP
fnp-4366	112	28	low	low	ADJ
fnp-4366	112	29	predicted	predict	VERB
fnp-4366	112	30	probability	probability	NOUN
fnp-4366	112	31	vectors	vector	NOUN
fnp-4366	112	32	for	for	ADP
fnp-4366	112	33	the	the	DET
fnp-4366	112	34	difficult	difficult	ADJ
fnp-4366	112	35	cases	case	NOUN
fnp-4366	112	36	.	.	PUNCT
fnp-4366	113	1	conclusions	conclusion	NOUN
fnp-4366	113	2	:	:	PUNCT
fnp-4366	113	3	our	our	PRON
fnp-4366	113	4	approach	approach	NOUN
fnp-4366	113	5	not	not	PART
fnp-4366	113	6	only	only	ADV
fnp-4366	113	7	provides	provide	VERB
fnp-4366	113	8	the	the	DET
fnp-4366	113	9	basis	basis	NOUN
fnp-4366	113	10	to	to	PART
fnp-4366	113	11	overcome	overcome	VERB
fnp-4366	113	12	current	current	ADJ
fnp-4366	113	13	limitations	limitation	NOUN
fnp-4366	113	14	in	in	ADP
fnp-4366	113	15	automated	automate	VERB
fnp-4366	113	16	cell	cell	NOUN
fnp-4366	113	17	classification	classification	NOUN
fnp-4366	113	18	for	for	ADP
fnp-4366	113	19	routine	routine	ADJ
fnp-4366	113	20	diagnostics	diagnostic	NOUN
fnp-4366	113	21	,	,	PUNCT
fnp-4366	113	22	but	but	CCONJ
fnp-4366	113	23	also	also	ADV
fnp-4366	113	24	demonstrates	demonstrate	VERB
fnp-4366	113	25	how	how	SCONJ
fnp-4366	113	26	a	a	DET
fnp-4366	113	27	visual	visual	ADJ
fnp-4366	113	28	explanation	explanation	NOUN
fnp-4366	113	29	framework	framework	NOUN
fnp-4366	113	30	can	can	AUX
fnp-4366	113	31	connect	connect	VERB
fnp-4366	113	32	machine	machine	NOUN
fnp-4366	113	33	decision	decision	NOUN
fnp-4366	113	34	-	-	PUNCT
fnp-4366	113	35	making	making	NOUN
fnp-4366	113	36	with	with	ADP
fnp-4366	113	37	cell	cell	NOUN
fnp-4366	113	38	properties	property	NOUN
fnp-4366	113	39	and	and	CCONJ
fnp-4366	113	40	thus	thus	ADV
fnp-4366	113	41	provide	provide	VERB
fnp-4366	113	42	a	a	DET
fnp-4366	113	43	novel	novel	NOUN
fnp-4366	113	44	versatile	versatile	ADJ
fnp-4366	113	45	and	and	CCONJ
fnp-4366	113	46	quantitative	quantitative	ADJ
fnp-4366	113	47	method	method	NOUN
fnp-4366	113	48	for	for	ADP
fnp-4366	113	49	investigating	investigate	VERB
fnp-4366	113	50	csf	csf	ADJ
fnp-4366	113	51	manifestations	manifestation	NOUN
fnp-4366	113	52	of	of	ADP
fnp-4366	113	53	various	various	ADJ
fnp-4366	113	54	neurological	neurological	ADJ
fnp-4366	113	55	diseases	disease	NOUN
fnp-4366	113	56	.	.	PUNCT
fnp-4366	113	57	  	  	SPACE
fnp-4366	114	1	1.07	1.07	NUM
fnp-4366	114	2	free	free	ADJ
fnp-4366	114	3	neuropathol	neuropathol	NOUN
fnp-4366	114	4	3:20:14	3:20:14	NUM
fnp-4366	114	5	proteomic	proteomic	ADJ
fnp-4366	114	6	profiling	profiling	NOUN
fnp-4366	114	7	of	of	ADP
fnp-4366	114	8	idh	idh	NOUN
fnp-4366	114	9	-	-	PUNCT
fnp-4366	114	10	mutant	mutant	NOUN
fnp-4366	114	11	gliomas	glioma	NOUN
fnp-4366	114	12	identifies	identify	VERB
fnp-4366	114	13	hip1r	hip1r	NOUN
fnp-4366	114	14	/	/	SYM
fnp-4366	114	15	vimentin	vimentin	NOUN
fnp-4366	114	16	as	as	ADP
fnp-4366	114	17	surrogate	surrogate	ADJ
fnp-4366	114	18	markers	marker	NOUN
fnp-4366	114	19	for	for	ADP
fnp-4366	114	20	1p/19q	1p/19q	PROPN
fnp-4366	114	21	codeletion	codeletion	NOUN
fnp-4366	114	22	and	and	CCONJ
fnp-4366	114	23	enables	enable	VERB
fnp-4366	114	24	prediction	prediction	NOUN
fnp-4366	114	25	of	of	ADP
fnp-4366	114	26	chromosomal	chromosomal	ADJ
fnp-4366	114	27	copy	copy	NOUN
fnp-4366	114	28	number	number	NOUN
fnp-4366	114	29	variations	variation	NOUN
fnp-4366	114	30	marius	marius	PROPN
fnp-4366	114	31	felix1	felix1	PROPN
fnp-4366	114	32	,	,	PUNCT
fnp-4366	114	33	dennis	dennis	PROPN
fnp-4366	114	34	friedel1	friedel1	PROPN
fnp-4366	114	35	,	,	PUNCT
fnp-4366	114	36	ashok	ashok	PROPN
fnp-4366	114	37	kumar	kumar	PROPN
fnp-4366	114	38	jayavelu2	jayavelu2	PROPN
fnp-4366	114	39	,	,	PUNCT
fnp-4366	114	40	katharina	katharina	PROPN
fnp-4366	114	41	filipski3	filipski3	PROPN
fnp-4366	114	42	,	,	PUNCT
fnp-4366	114	43	anne	anne	PROPN
fnp-4366	114	44	-	-	PUNCT
fnp-4366	114	45	kathrin	kathrin	PROPN
fnp-4366	114	46	reinhard1	reinhard1	PROPN
fnp-4366	114	47	,	,	PUNCT
fnp-4366	114	48	uwe	uwe	PROPN
fnp-4366	114	49	warnken4	warnken4	PROPN
fnp-4366	114	50	,	,	PUNCT
fnp-4366	114	51	damian	damian	PROPN
fnp-4366	114	52	stichel1	stichel1	PROPN
fnp-4366	114	53	,	,	PUNCT
fnp-4366	114	54	daniel	daniel	PROPN
fnp-4366	114	55	schrimpf1	schrimpf1	PROPN
fnp-4366	114	56	,	,	PUNCT
fnp-4366	114	57	andrey	andrey	PROPN
fnp-4366	114	58	korshunov1	korshunov1	PROPN
fnp-4366	114	59	,	,	PUNCT
fnp-4366	114	60	yueting	yuete	VERB
fnp-4366	114	61	wang1	wang1	NOUN
fnp-4366	114	62	,	,	PUNCT
fnp-4366	114	63	tobias	tobias	PROPN
fnp-4366	114	64	kessler4	kessler4	PROPN
fnp-4366	114	65	,	,	PUNCT
fnp-4366	114	66	nima	nima	PROPN
fnp-4366	114	67	etminan5	etminan5	PROPN
fnp-4366	114	68	,	,	PUNCT
fnp-4366	114	69	andreas	andreas	PROPN
fnp-4366	114	70	unterberg6	unterberg6	PROPN
fnp-4366	114	71	,	,	PUNCT
fnp-4366	114	72	christel	christel	PROPN
fnp-4366	114	73	herolod	herolod	PROPN
fnp-4366	114	74	-	-	PUNCT
fnp-4366	114	75	mende6	mende6	PROPN
fnp-4366	114	76	,	,	PUNCT
fnp-4366	114	77	laura	laura	PROPN
fnp-4366	114	78	heikaus7	heikaus7	PROPN
fnp-4366	114	79	,	,	PUNCT
fnp-4366	114	80	felix	felix	PROPN
fnp-4366	114	81	sahm1	sahm1	PROPN
fnp-4366	114	82	,	,	PUNCT
fnp-4366	114	83	wolfgang	wolfgang	PROPN
fnp-4366	114	84	wick4	wick4	PROPN
fnp-4366	114	85	,	,	PUNCT
fnp-4366	114	86	patrick	patrick	PROPN
fnp-4366	114	87	n.	n.	PROPN
fnp-4366	114	88	harter3	harter3	PROPN
fnp-4366	114	89	,	,	PUNCT
fnp-4366	114	90	andreas	andreas	PROPN
fnp-4366	114	91	von	von	PROPN
fnp-4366	114	92	deimling1	deimling1	PROPN
fnp-4366	114	93	,	,	PUNCT
fnp-4366	114	94	david	david	PROPN
fnp-4366	114	95	e.	e.	PROPN
fnp-4366	114	96	reuss1	reuss1	PROPN
fnp-4366	114	97	1	1	NUM
fnp-4366	114	98	department	department	NOUN
fnp-4366	114	99	of	of	ADP
fnp-4366	114	100	neuropathology	neuropathology	NOUN
fnp-4366	114	101	,	,	PUNCT
fnp-4366	114	102	institute	institute	PROPN
fnp-4366	114	103	of	of	ADP
fnp-4366	114	104	pathology	pathology	PROPN
fnp-4366	114	105	,	,	PUNCT
fnp-4366	114	106	heidelberg	heidelberg	PROPN
fnp-4366	114	107	,	,	PUNCT
fnp-4366	114	108	deutschland	deutschland	NOUN
fnp-4366	114	109	2	2	NUM
fnp-4366	114	110	clinical	clinical	ADJ
fnp-4366	114	111	cooperation	cooperation	NOUN
fnp-4366	114	112	unit	unit	NOUN
fnp-4366	114	113	pediatric	pediatric	ADJ
fnp-4366	114	114	leukemia	leukemia	NOUN
fnp-4366	114	115	,	,	PUNCT
fnp-4366	114	116	german	german	ADJ
fnp-4366	114	117	cancer	cancer	NOUN
fnp-4366	114	118	research	research	NOUN
fnp-4366	114	119	center	center	NOUN
fnp-4366	114	120	(	(	PUNCT
fnp-4366	114	121	dkfz	dkfz	PROPN
fnp-4366	114	122	)	)	PUNCT
fnp-4366	114	123	,	,	PUNCT
fnp-4366	114	124	heidelberg	heidelberg	PROPN
fnp-4366	114	125	,	,	PUNCT
fnp-4366	114	126	deutschland	deutschland	PROPN
fnp-4366	114	127	3	3	NUM
fnp-4366	114	128	institute	institute	PROPN
fnp-4366	114	129	of	of	ADP
fnp-4366	114	130	neurology	neurology	NOUN
fnp-4366	114	131	,	,	PUNCT
fnp-4366	114	132	edinger	edinger	PROPN
fnp-4366	114	133	institute	institute	PROPN
fnp-4366	114	134	,	,	PUNCT
fnp-4366	114	135	heidelberg	heidelberg	PROPN
fnp-4366	114	136	,	,	PUNCT
fnp-4366	114	137	deutschland	deutschland	NOUN
fnp-4366	114	138	4	4	NUM
fnp-4366	114	139	clinical	clinical	ADJ
fnp-4366	114	140	cooperation	cooperation	NOUN
fnp-4366	114	141	unit	unit	NOUN
fnp-4366	114	142	neurooncology	neurooncology	NOUN
fnp-4366	114	143	,	,	PUNCT
fnp-4366	114	144	german	german	ADJ
fnp-4366	114	145	consortium	consortium	NOUN
fnp-4366	114	146	for	for	ADP
fnp-4366	114	147	translational	translational	ADJ
fnp-4366	114	148	cancer	cancer	NOUN
fnp-4366	114	149	research	research	NOUN
fnp-4366	114	150	(	(	PUNCT
fnp-4366	114	151	dktk	dktk	NOUN
fnp-4366	114	152	)	)	PUNCT
fnp-4366	114	153	,	,	PUNCT
fnp-4366	114	154	german	german	ADJ
fnp-4366	114	155	cancer	cancer	NOUN
fnp-4366	114	156	research	research	NOUN
fnp-4366	114	157	center	center	NOUN
fnp-4366	114	158	(	(	PUNCT
fnp-4366	114	159	dkfz	dkfz	PROPN
fnp-4366	114	160	)	)	PUNCT
fnp-4366	114	161	,	,	PUNCT
fnp-4366	114	162	heidelberg	heidelberg	NOUN
fnp-4366	114	163	,	,	PUNCT
fnp-4366	114	164	deutschland	deutschland	NOUN
fnp-4366	114	165	5	5	NUM
fnp-4366	114	166	department	department	NOUN
fnp-4366	114	167	of	of	ADP
fnp-4366	114	168	neurosurgery	neurosurgery	NOUN
fnp-4366	114	169	,	,	PUNCT
fnp-4366	114	170	mannheim	mannheim	PROPN
fnp-4366	114	171	,	,	PUNCT
fnp-4366	114	172	deutschland	deutschland	NOUN
fnp-4366	114	173	6	6	NUM
fnp-4366	114	174	department	department	NOUN
fnp-4366	114	175	of	of	ADP
fnp-4366	114	176	neurosurgery	neurosurgery	NOUN
fnp-4366	114	177	,	,	PUNCT
fnp-4366	114	178	heidelberg	heidelberg	NOUN
fnp-4366	114	179	,	,	PUNCT
fnp-4366	114	180	deutschland	deutschland	NOUN
fnp-4366	114	181	7	7	NUM
fnp-4366	114	182	bruker	bruker	PROPN
fnp-4366	114	183	gmbh	gmbh	PROPN
fnp-4366	114	184	,	,	PUNCT
fnp-4366	114	185	bremen	breman	NOUN
fnp-4366	114	186	,	,	PUNCT
fnp-4366	114	187	deutschland	deutschland	NOUN
fnp-4366	114	188	background	background	NOUN
fnp-4366	114	189	:	:	PUNCT
fnp-4366	114	190	idh	idh	NOUN
fnp-4366	114	191	-	-	PUNCT
fnp-4366	114	192	mutant	mutant	NOUN
fnp-4366	114	193	gliomas	glioma	NOUN
fnp-4366	114	194	are	be	AUX
fnp-4366	114	195	a	a	DET
fnp-4366	114	196	common	common	ADJ
fnp-4366	114	197	but	but	CCONJ
fnp-4366	114	198	heterogenous	heterogenous	ADJ
fnp-4366	114	199	group	group	NOUN
fnp-4366	114	200	of	of	ADP
fnp-4366	114	201	diffuse	diffuse	NOUN
fnp-4366	114	202	gliomas	glioma	NOUN
fnp-4366	114	203	.	.	PUNCT
fnp-4366	115	1	chromosomal	chromosomal	ADJ
fnp-4366	115	2	copy	copy	NOUN
fnp-4366	115	3	number	number	NOUN
fnp-4366	115	4	variations	variation	NOUN
fnp-4366	115	5	(	(	PUNCT
fnp-4366	115	6	cnv	cnv	NOUN
fnp-4366	115	7	)	)	PUNCT
fnp-4366	115	8	are	be	AUX
fnp-4366	115	9	a	a	DET
fnp-4366	115	10	hallmark	hallmark	NOUN
fnp-4366	115	11	of	of	ADP
fnp-4366	115	12	many	many	ADJ
fnp-4366	115	13	different	different	ADJ
fnp-4366	115	14	types	type	NOUN
fnp-4366	115	15	of	of	ADP
fnp-4366	115	16	cancer	cancer	NOUN
fnp-4366	115	17	and	and	CCONJ
fnp-4366	115	18	1p/19q	1p/19q	NOUN
fnp-4366	115	19	codeletion	codeletion	NOUN
fnp-4366	115	20	is	be	AUX
fnp-4366	115	21	mandatory	mandatory	ADJ
fnp-4366	115	22	to	to	PART
fnp-4366	115	23	differentiate	differentiate	VERB
fnp-4366	115	24	“	"	PUNCT
fnp-4366	115	25	astrocytoma	astrocytoma	NOUN
fnp-4366	115	26	,	,	PUNCT
fnp-4366	115	27	idh	idh	NOUN
fnp-4366	115	28	mutant	mutant	NOUN
fnp-4366	115	29	”	"	PUNCT
fnp-4366	115	30	from	from	ADP
fnp-4366	115	31	“	"	PUNCT
fnp-4366	115	32	oligodendroglioma	oligodendroglioma	ADJ
fnp-4366	115	33	,	,	PUNCT
fnp-4366	115	34	idh	idh	NOUN
fnp-4366	115	35	-	-	PUNCT
fnp-4366	115	36	mutant	mutant	NOUN
fnp-4366	115	37	and	and	CCONJ
fnp-4366	115	38	1p/19q	1p/19q	NOUN
fnp-4366	115	39	-	-	PUNCT
fnp-4366	115	40	codeleted	codelete	VERB
fnp-4366	115	41	”	"	PUNCT
fnp-4366	115	42	.	.	PUNCT
fnp-4366	116	1	currently	currently	ADV
fnp-4366	116	2	,	,	PUNCT
fnp-4366	116	3	loss	loss	NOUN
fnp-4366	116	4	of	of	ADP
fnp-4366	116	5	nuclear	nuclear	ADJ
fnp-4366	116	6	atrx	atrx	NOUN
fnp-4366	116	7	is	be	AUX
fnp-4366	116	8	the	the	DET
fnp-4366	116	9	only	only	ADJ
fnp-4366	116	10	surrogate	surrogate	ADJ
fnp-4366	116	11	marker	marker	NOUN
fnp-4366	116	12	for	for	ADP
fnp-4366	116	13	an	an	DET
fnp-4366	116	14	1p/19q	1p/19q	ADJ
fnp-4366	116	15	-	-	PUNCT
fnp-4366	116	16	wildtype	wildtype	NOUN
fnp-4366	116	17	status	status	NOUN
fnp-4366	116	18	accepted	accept	VERB
fnp-4366	116	19	by	by	ADP
fnp-4366	116	20	who	who	PRON
fnp-4366	116	21	.	.	PUNCT
fnp-4366	117	1	unmet	unmet	NOUN
fnp-4366	117	2	diagnostic	diagnostic	ADJ
fnp-4366	117	3	needs	need	NOUN
fnp-4366	117	4	are	be	AUX
fnp-4366	117	5	improved	improve	VERB
fnp-4366	117	6	surrogate	surrogate	ADJ
fnp-4366	117	7	markers	marker	NOUN
fnp-4366	117	8	for	for	ADP
fnp-4366	117	9	1p/19q	1p/19q	PROPN
fnp-4366	117	10	codeletion	codeletion	NOUN
fnp-4366	117	11	in	in	ADP
fnp-4366	117	12	atrx	atrx	NOUN
fnp-4366	117	13	retaining	retain	VERB
fnp-4366	117	14	gliomas	glioma	NOUN
fnp-4366	117	15	and	and	CCONJ
fnp-4366	117	16	a	a	DET
fnp-4366	117	17	rapid	rapid	ADJ
fnp-4366	117	18	determination	determination	NOUN
fnp-4366	117	19	of	of	ADP
fnp-4366	117	20	cnvs	cnvs	NOUN
fnp-4366	117	21	in	in	ADP
fnp-4366	117	22	general	general	ADJ
fnp-4366	117	23	.	.	PUNCT
fnp-4366	118	1	aims	aim	VERB
fnp-4366	118	2	:	:	PUNCT
fnp-4366	118	3	we	we	PRON
fnp-4366	118	4	aimed	aim	VERB
fnp-4366	118	5	at	at	ADP
fnp-4366	118	6	the	the	DET
fnp-4366	118	7	identification	identification	NOUN
fnp-4366	118	8	of	of	ADP
fnp-4366	118	9	protein	protein	NOUN
fnp-4366	118	10	-	-	PUNCT
fnp-4366	118	11	level	level	NOUN
fnp-4366	118	12	surrogate	surrogate	ADJ
fnp-4366	118	13	markers	marker	NOUN
fnp-4366	118	14	for	for	ADP
fnp-4366	118	15	1p/19q	1p/19q	PROPN
fnp-4366	118	16	codeletion	codeletion	NOUN
fnp-4366	118	17	suitable	suitable	ADJ
fnp-4366	118	18	for	for	ADP
fnp-4366	118	19	immunohistochemical	immunohistochemical	ADJ
fnp-4366	118	20	assays	assay	NOUN
fnp-4366	118	21	as	as	ADV
fnp-4366	118	22	well	well	ADV
fnp-4366	118	23	as	as	ADP
fnp-4366	118	24	proteomic	proteomic	ADJ
fnp-4366	118	25	signatures	signature	NOUN
fnp-4366	118	26	associated	associate	VERB
fnp-4366	118	27	with	with	ADP
fnp-4366	118	28	chromosomal	chromosomal	ADJ
fnp-4366	118	29	alterations	alteration	NOUN
fnp-4366	118	30	in	in	ADP
fnp-4366	118	31	general	general	ADJ
fnp-4366	118	32	.	.	PUNCT
fnp-4366	119	1	methods	method	NOUN
fnp-4366	119	2	:	:	PUNCT
fnp-4366	119	3	we	we	PRON
fnp-4366	119	4	used	use	VERB
fnp-4366	119	5	mass	mass	NOUN
fnp-4366	119	6	-	-	PUNCT
fnp-4366	119	7	spectrometry	spectrometry	NOUN
fnp-4366	119	8	(	(	PUNCT
fnp-4366	119	9	ms	ms	NOUN
fnp-4366	119	10	)	)	PUNCT
fnp-4366	119	11	based	base	VERB
fnp-4366	119	12	proteomics	proteomic	NOUN
fnp-4366	119	13	to	to	PART
fnp-4366	119	14	analyze	analyze	VERB
fnp-4366	119	15	idh	idh	NOUN
fnp-4366	119	16	-	-	PUNCT
fnp-4366	119	17	mutant	mutant	NOUN
fnp-4366	119	18	gliomas	glioma	NOUN
fnp-4366	119	19	pre	pre	ADJ
fnp-4366	119	20	-	-	VERB
fnp-4366	119	21	characterized	characterize	VERB
fnp-4366	119	22	by	by	ADP
fnp-4366	119	23	dna	dna	PROPN
fnp-4366	119	24	methylation	methylation	NOUN
fnp-4366	119	25	profiling	profiling	NOUN
fnp-4366	119	26	.	.	PUNCT
fnp-4366	120	1	a	a	DET
fnp-4366	120	2	discovery	discovery	NOUN
fnp-4366	120	3	series	series	NOUN
fnp-4366	120	4	containing	contain	VERB
fnp-4366	120	5	35	35	NUM
fnp-4366	120	6	fresh	fresh	ADJ
fnp-4366	120	7	frozen	frozen	ADJ
fnp-4366	120	8	(	(	PUNCT
fnp-4366	120	9	ff	ff	NOUN
fnp-4366	120	10	)	)	PUNCT
fnp-4366	120	11	and	and	CCONJ
fnp-4366	120	12	72	72	NUM
fnp-4366	120	13	formalin	formalin	NOUN
fnp-4366	120	14	fixed	fix	VERB
fnp-4366	120	15	and	and	CCONJ
fnp-4366	120	16	paraffin	paraffin	NOUN
fnp-4366	120	17	embedded	embed	VERB
fnp-4366	120	18	(	(	PUNCT
fnp-4366	120	19	ffpe	ffpe	NOUN
fnp-4366	120	20	)	)	PUNCT
fnp-4366	120	21	tumors	tumor	NOUN
fnp-4366	120	22	were	be	AUX
fnp-4366	120	23	analyzed	analyze	VERB
fnp-4366	120	24	and	and	CCONJ
fnp-4366	120	25	potential	potential	ADJ
fnp-4366	120	26	biomarkers	biomarker	NOUN
fnp-4366	120	27	for	for	ADP
fnp-4366	120	28	1p/19q	1p/19q	NOUN
fnp-4366	120	29	codeletion	codeletion	NOUN
fnp-4366	120	30	were	be	AUX
fnp-4366	120	31	identified	identify	VERB
fnp-4366	120	32	.	.	PUNCT
fnp-4366	121	1	a	a	DET
fnp-4366	121	2	subsequent	subsequent	ADJ
fnp-4366	121	3	validation	validation	NOUN
fnp-4366	121	4	series	series	NOUN
fnp-4366	121	5	consisting	consist	VERB
fnp-4366	121	6	of	of	ADP
fnp-4366	121	7	50	50	NUM
fnp-4366	121	8	oligodendrogliomas	oligodendroglioma	NOUN
fnp-4366	121	9	and	and	CCONJ
fnp-4366	121	10	50	50	NUM
fnp-4366	121	11	astrocytomas	astrocytoma	NOUN
fnp-4366	121	12	was	be	AUX
fnp-4366	121	13	evaluated	evaluate	VERB
fnp-4366	121	14	using	use	VERB
fnp-4366	121	15	immunohistochemistry	immunohistochemistry	NOUN
fnp-4366	121	16	to	to	PART
fnp-4366	121	17	confirm	confirm	VERB
fnp-4366	121	18	potential	potential	ADJ
fnp-4366	121	19	biomarker	biomarker	NOUN
fnp-4366	121	20	identifications	identification	NOUN
fnp-4366	121	21	based	base	VERB
fnp-4366	121	22	on	on	ADP
fnp-4366	121	23	proteomic	proteomic	ADJ
fnp-4366	121	24	discoveries	discovery	NOUN
fnp-4366	121	25	.	.	PUNCT
fnp-4366	122	1	furthermore	furthermore	ADV
fnp-4366	122	2	,	,	PUNCT
fnp-4366	122	3	an	an	DET
fnp-4366	122	4	additional	additional	ADJ
fnp-4366	122	5	validation	validation	NOUN
fnp-4366	122	6	cohort	cohort	NOUN
fnp-4366	122	7	of	of	ADP
fnp-4366	122	8	69	69	NUM
fnp-4366	122	9	idh	idh	NOUN
fnp-4366	122	10	-	-	PUNCT
fnp-4366	122	11	mutant	mutant	NOUN
fnp-4366	122	12	gliomas	glioma	NOUN
fnp-4366	122	13	was	be	AUX
fnp-4366	122	14	stained	stain	VERB
fnp-4366	122	15	and	and	CCONJ
fnp-4366	122	16	evaluated	evaluate	VERB
fnp-4366	122	17	in	in	ADP
fnp-4366	122	18	a	a	DET
fnp-4366	122	19	separate	separate	ADJ
fnp-4366	122	20	institution	institution	NOUN
fnp-4366	122	21	.	.	PUNCT
fnp-4366	123	1	results	result	NOUN
fnp-4366	123	2	:	:	PUNCT
fnp-4366	123	3	proteomic	proteomic	ADJ
fnp-4366	123	4	data	datum	NOUN
fnp-4366	123	5	from	from	ADP
fnp-4366	123	6	ff	ff	NOUN
fnp-4366	123	7	and	and	CCONJ
fnp-4366	123	8	ffpe	ffpe	ADJ
fnp-4366	123	9	tissues	tissue	NOUN
fnp-4366	123	10	were	be	AUX
fnp-4366	123	11	comparable	comparable	ADJ
fnp-4366	123	12	.	.	PUNCT
fnp-4366	124	1	highly	highly	ADV
fnp-4366	124	2	specific	specific	ADJ
fnp-4366	124	3	protein	protein	NOUN
fnp-4366	124	4	patters	patter	NOUN
fnp-4366	124	5	were	be	AUX
fnp-4366	124	6	identified	identify	VERB
fnp-4366	124	7	,	,	PUNCT
fnp-4366	124	8	which	which	PRON
fnp-4366	124	9	could	could	AUX
fnp-4366	124	10	distinguish	distinguish	VERB
fnp-4366	124	11	between	between	ADP
fnp-4366	124	12	oligodendroglioma	oligodendroglioma	NOUN
fnp-4366	124	13	and	and	CCONJ
fnp-4366	124	14	astrocytoma	astrocytoma	NOUN
fnp-4366	124	15	.	.	PUNCT
fnp-4366	125	1	oligodendrogliomas	oligodendroglioma	NOUN
fnp-4366	125	2	showed	show	VERB
fnp-4366	125	3	high	high	ADJ
fnp-4366	125	4	hip1r	hip1r	ADJ
fnp-4366	125	5	and	and	CCONJ
fnp-4366	125	6	low	low	ADJ
fnp-4366	125	7	vimentin	vimentin	NOUN
fnp-4366	125	8	(	(	PUNCT
fnp-4366	125	9	vim	vim	NOUN
fnp-4366	125	10	)	)	PUNCT
fnp-4366	125	11	staining	stain	VERB
fnp-4366	125	12	intensities	intensity	NOUN
fnp-4366	125	13	and	and	CCONJ
fnp-4366	125	14	astrocytomas	astrocytoma	NOUN
fnp-4366	125	15	low	low	ADJ
fnp-4366	125	16	hip1r	hip1r	PROPN
fnp-4366	125	17	and	and	CCONJ
fnp-4366	125	18	high	high	ADJ
fnp-4366	125	19	vim	vim	ADJ
fnp-4366	125	20	staining	stain	VERB
fnp-4366	125	21	intensities	intensity	NOUN
fnp-4366	125	22	.	.	PUNCT
fnp-4366	126	1	blinded	blind	VERB
fnp-4366	126	2	evaluation	evaluation	NOUN
fnp-4366	126	3	of	of	ADP
fnp-4366	126	4	the	the	DET
fnp-4366	126	5	validation	validation	NOUN
fnp-4366	126	6	cohort	cohort	NOUN
fnp-4366	126	7	revealed	reveal	VERB
fnp-4366	126	8	a	a	DET
fnp-4366	126	9	specificity	specificity	NOUN
fnp-4366	126	10	of	of	ADP
fnp-4366	126	11	100	100	NUM
fnp-4366	126	12	%	%	NOUN
fnp-4366	126	13	and	and	CCONJ
fnp-4366	126	14	sensitivity	sensitivity	NOUN
fnp-4366	126	15	90	90	NUM
fnp-4366	126	16	-	-	SYM
fnp-4366	126	17	94	94	NUM
fnp-4366	126	18	%	%	NOUN
fnp-4366	126	19	between	between	ADP
fnp-4366	126	20	two	two	NUM
fnp-4366	126	21	observers	observer	NOUN
fnp-4366	126	22	for	for	ADP
fnp-4366	126	23	1p/19q	1p/19q	PROPN
fnp-4366	126	24	prediction	prediction	NOUN
fnp-4366	126	25	.	.	PUNCT
fnp-4366	127	1	combined	combined	ADJ
fnp-4366	127	2	evaluation	evaluation	NOUN
fnp-4366	127	3	with	with	ADP
fnp-4366	127	4	atrx	atrx	NOUN
fnp-4366	127	5	increased	increase	VERB
fnp-4366	127	6	sensitivity	sensitivity	NOUN
fnp-4366	127	7	to	to	ADP
fnp-4366	127	8	96	96	NUM
fnp-4366	127	9	%	%	NOUN
fnp-4366	127	10	.	.	PUNCT
fnp-4366	128	1	an	an	DET
fnp-4366	128	2	additional	additional	ADJ
fnp-4366	128	3	verification	verification	NOUN
fnp-4366	128	4	cohort	cohort	NOUN
fnp-4366	128	5	stained	stain	VERB
fnp-4366	128	6	and	and	CCONJ
fnp-4366	128	7	evaluated	evaluate	VERB
fnp-4366	128	8	in	in	ADP
fnp-4366	128	9	a	a	DET
fnp-4366	128	10	separate	separate	ADJ
fnp-4366	128	11	institution	institution	NOUN
fnp-4366	128	12	revealed	reveal	VERB
fnp-4366	128	13	similar	similar	ADJ
fnp-4366	128	14	prediction	prediction	NOUN
fnp-4366	128	15	performances	performance	NOUN
fnp-4366	128	16	.	.	PUNCT
fnp-4366	129	1	further	further	ADJ
fnp-4366	129	2	analyses	analysis	NOUN
fnp-4366	129	3	revealed	reveal	VERB
fnp-4366	129	4	that	that	SCONJ
fnp-4366	129	5	a	a	DET
fnp-4366	129	6	high	high	ADJ
fnp-4366	129	7	proportion	proportion	NOUN
fnp-4366	129	8	of	of	ADP
fnp-4366	129	9	the	the	DET
fnp-4366	129	10	differentially	differentially	ADV
fnp-4366	129	11	regulated	regulate	VERB
fnp-4366	129	12	proteins	protein	NOUN
fnp-4366	129	13	between	between	ADP
fnp-4366	129	14	astrocytoma	astrocytoma	NOUN
fnp-4366	129	15	and	and	CCONJ
fnp-4366	129	16	oligodendroglioma	oligodendroglioma	NOUN
fnp-4366	129	17	are	be	AUX
fnp-4366	129	18	coded	code	VERB
fnp-4366	129	19	on	on	ADP
fnp-4366	129	20	the	the	DET
fnp-4366	129	21	1p	1p	NUM
fnp-4366	129	22	and	and	CCONJ
fnp-4366	129	23	19q	19q	NUM
fnp-4366	129	24	chromosome	chromosome	NOUN
fnp-4366	129	25	arms	arm	NOUN
fnp-4366	129	26	.	.	PUNCT
fnp-4366	130	1	by	by	ADP
fnp-4366	130	2	generating	generate	VERB
fnp-4366	130	3	virtual	virtual	ADJ
fnp-4366	130	4	protein	protein	NOUN
fnp-4366	130	5	abundance	abundance	NOUN
fnp-4366	130	6	means	mean	VERB
fnp-4366	130	7	from	from	ADP
fnp-4366	130	8	unregulated	unregulated	ADJ
fnp-4366	130	9	chromosome	chromosome	NOUN
fnp-4366	130	10	arms	arm	NOUN
fnp-4366	130	11	,	,	PUNCT
fnp-4366	130	12	chromosomal	chromosomal	ADJ
fnp-4366	130	13	protein	protein	NOUN
fnp-4366	130	14	ratios	ratio	NOUN
fnp-4366	130	15	(	(	PUNCT
fnp-4366	130	16	cprs	cprs	NOUN
fnp-4366	130	17	)	)	PUNCT
fnp-4366	130	18	were	be	AUX
fnp-4366	130	19	calculated	calculate	VERB
fnp-4366	130	20	,	,	PUNCT
fnp-4366	130	21	which	which	PRON
fnp-4366	130	22	helped	helped	AUX
fnp-4366	130	23	predict	predict	VERB
fnp-4366	130	24	copy	copy	NOUN
fnp-4366	130	25	number	number	NOUN
fnp-4366	130	26	variations	variation	NOUN
fnp-4366	130	27	,	,	PUNCT
fnp-4366	130	28	showing	show	VERB
fnp-4366	130	29	high	high	ADJ
fnp-4366	130	30	correlation	correlation	NOUN
fnp-4366	130	31	with	with	ADP
fnp-4366	130	32	cnv	cnv	PROPN
fnp-4366	130	33	plots	plot	NOUN
fnp-4366	130	34	from	from	ADP
fnp-4366	130	35	genome	genome	NOUN
fnp-4366	130	36	wide	wide	ADJ
fnp-4366	130	37	dna	dna	PROPN
fnp-4366	130	38	methylation	methylation	NOUN
fnp-4366	130	39	profiles	profile	NOUN
fnp-4366	130	40	.	.	PUNCT
fnp-4366	131	1	conclusions	conclusion	NOUN
fnp-4366	131	2	:	:	PUNCT
fnp-4366	131	3	ms	ms	NOUN
fnp-4366	131	4	based	base	VERB
fnp-4366	131	5	analysis	analysis	NOUN
fnp-4366	131	6	of	of	ADP
fnp-4366	131	7	ffpe	ffpe	ADJ
fnp-4366	131	8	tissue	tissue	NOUN
fnp-4366	131	9	highly	highly	ADV
fnp-4366	131	10	correlates	correlate	VERB
fnp-4366	131	11	with	with	ADP
fnp-4366	131	12	ff	ff	ADJ
fnp-4366	131	13	tissue	tissue	NOUN
fnp-4366	131	14	,	,	PUNCT
fnp-4366	131	15	allowing	allow	VERB
fnp-4366	131	16	in	in	ADP
fnp-4366	131	17	depth	depth	NOUN
fnp-4366	131	18	differential	differential	ADJ
fnp-4366	131	19	proteomic	proteomic	ADJ
fnp-4366	131	20	profiling	profiling	NOUN
fnp-4366	131	21	.	.	PUNCT
fnp-4366	132	1	proteomics	proteomic	NOUN
fnp-4366	132	2	enables	enable	VERB
fnp-4366	132	3	the	the	DET
fnp-4366	132	4	discovery	discovery	NOUN
fnp-4366	132	5	of	of	ADP
fnp-4366	132	6	new	new	ADJ
fnp-4366	132	7	biomarkers	biomarker	NOUN
fnp-4366	132	8	and	and	CCONJ
fnp-4366	132	9	has	have	VERB
fnp-4366	132	10	great	great	ADJ
fnp-4366	132	11	potential	potential	NOUN
fnp-4366	132	12	for	for	ADP
fnp-4366	132	13	the	the	DET
fnp-4366	132	14	future	future	NOUN
fnp-4366	132	15	of	of	ADP
fnp-4366	132	16	brain	brain	NOUN
fnp-4366	132	17	tumor	tumor	NOUN
fnp-4366	132	18	diagnostics	diagnostic	NOUN
fnp-4366	132	19	.	.	PUNCT
fnp-4366	133	1	immunohistochemistry	immunohistochemistry	NOUN
fnp-4366	133	2	for	for	ADP
fnp-4366	133	3	hip1r	hip1r	PROPN
fnp-4366	133	4	,	,	PUNCT
fnp-4366	133	5	vim	vim	NOUN
fnp-4366	133	6	and	and	CCONJ
fnp-4366	133	7	atrx	atrx	PROPN
fnp-4366	133	8	can	can	AUX
fnp-4366	133	9	predict	predict	VERB
fnp-4366	133	10	1p/19q	1p/19q	ADJ
fnp-4366	133	11	status	status	NOUN
fnp-4366	133	12	with	with	ADP
fnp-4366	133	13	high	high	ADJ
fnp-4366	133	14	specificity	specificity	NOUN
fnp-4366	133	15	and	and	CCONJ
fnp-4366	133	16	sensitivity	sensitivity	NOUN
fnp-4366	133	17	.	.	PUNCT
fnp-4366	134	1	cprs	cprs	NOUN
fnp-4366	134	2	are	be	AUX
fnp-4366	134	3	a	a	DET
fnp-4366	134	4	promising	promising	ADJ
fnp-4366	134	5	tool	tool	NOUN
fnp-4366	134	6	for	for	ADP
fnp-4366	134	7	the	the	DET
fnp-4366	134	8	rapid	rapid	ADJ
fnp-4366	134	9	proteome	proteome	NOUN
fnp-4366	134	10	-	-	PUNCT
fnp-4366	134	11	based	base	VERB
fnp-4366	134	12	determination	determination	NOUN
fnp-4366	134	13	of	of	ADP
fnp-4366	134	14	chromosomal	chromosomal	ADJ
fnp-4366	134	15	copy	copy	NOUN
fnp-4366	134	16	number	number	NOUN
fnp-4366	134	17	variations	variation	NOUN
fnp-4366	134	18	.	.	PUNCT
fnp-4366	134	19	  	  	SPACE
fnp-4366	135	1	1.08	1.08	NUM
fnp-4366	135	2	free	free	ADJ
fnp-4366	135	3	neuropathol	neuropathol	NOUN
fnp-4366	135	4	3:20:16	3:20:16	NUM
fnp-4366	135	5	cellular	cellular	ADJ
fnp-4366	135	6	digital	digital	ADJ
fnp-4366	135	7	neuropathology	neuropathology	NOUN
fnp-4366	135	8	jonas	jonas	PROPN
fnp-4366	135	9	franz1	franz1	PROPN
fnp-4366	135	10	,	,	PUNCT
fnp-4366	135	11	christine	christine	PROPN
fnp-4366	135	12	stadelmann1	stadelmann1	VERB
fnp-4366	135	13	1	1	NUM
fnp-4366	135	14	institut	institut	PROPN
fnp-4366	135	15	für	für	PROPN
fnp-4366	135	16	neuropathologie	neuropathologie	PROPN
fnp-4366	135	17	,	,	PUNCT
fnp-4366	135	18	universitätsmedizin	universitätsmedizin	PROPN
fnp-4366	135	19	göttingen	göttingen	PROPN
fnp-4366	135	20	,	,	PUNCT
fnp-4366	135	21	göttingen	göttingen	NOUN
fnp-4366	135	22	,	,	PUNCT
fnp-4366	135	23	deutschland	deutschland	NOUN
fnp-4366	135	24	background	background	NOUN
fnp-4366	135	25	:	:	PUNCT
fnp-4366	135	26	neuropathology	neuropathology	NOUN
fnp-4366	135	27	is	be	AUX
fnp-4366	135	28	traditionally	traditionally	ADV
fnp-4366	135	29	based	base	VERB
fnp-4366	135	30	on	on	ADP
fnp-4366	135	31	histological	histological	ADJ
fnp-4366	135	32	analysis	analysis	NOUN
fnp-4366	135	33	of	of	ADP
fnp-4366	135	34	tissue	tissue	NOUN
fnp-4366	135	35	.	.	PUNCT
fnp-4366	136	1	aside	aside	ADP
fnp-4366	136	2	molecular	molecular	ADJ
fnp-4366	136	3	pathology	pathology	NOUN
fnp-4366	136	4	also	also	ADV
fnp-4366	136	5	the	the	DET
fnp-4366	136	6	introduction	introduction	NOUN
fnp-4366	136	7	of	of	ADP
fnp-4366	136	8	digital	digital	ADJ
fnp-4366	136	9	microscopy	microscopy	NOUN
fnp-4366	136	10	is	be	AUX
fnp-4366	136	11	changing	change	VERB
fnp-4366	136	12	the	the	DET
fnp-4366	136	13	working	work	VERB
fnp-4366	136	14	environment	environment	NOUN
fnp-4366	136	15	of	of	ADP
fnp-4366	136	16	neuropathologists	neuropathologist	NOUN
fnp-4366	136	17	.	.	PUNCT
fnp-4366	137	1	digital	digital	ADJ
fnp-4366	137	2	pathology	pathology	NOUN
fnp-4366	137	3	comes	come	VERB
fnp-4366	137	4	with	with	ADP
fnp-4366	137	5	modern	modern	ADJ
fnp-4366	137	6	algorithms	algorithm	NOUN
fnp-4366	137	7	for	for	ADP
fnp-4366	137	8	image	image	NOUN
fnp-4366	137	9	quantification	quantification	NOUN
fnp-4366	137	10	.	.	PUNCT
fnp-4366	138	1	mostly	mostly	ADV
fnp-4366	138	2	these	these	DET
fnp-4366	138	3	algorithms	algorithm	NOUN
fnp-4366	138	4	are	be	AUX
fnp-4366	138	5	capable	capable	ADJ
fnp-4366	138	6	of	of	ADP
fnp-4366	138	7	solving	solve	VERB
fnp-4366	138	8	sophisticated	sophisticated	ADJ
fnp-4366	138	9	classification	classification	NOUN
fnp-4366	138	10	or	or	CCONJ
fnp-4366	138	11	segmentation	segmentation	NOUN
fnp-4366	138	12	problems	problem	NOUN
fnp-4366	138	13	.	.	PUNCT
fnp-4366	139	1	while	while	SCONJ
fnp-4366	139	2	classification	classification	NOUN
fnp-4366	139	3	is	be	AUX
fnp-4366	139	4	often	often	ADV
fnp-4366	139	5	applied	apply	VERB
fnp-4366	139	6	to	to	ADP
fnp-4366	139	7	whole	whole	ADJ
fnp-4366	139	8	disease	disease	NOUN
fnp-4366	139	9	entities	entity	NOUN
fnp-4366	139	10	and	and	CCONJ
fnp-4366	139	11	segmentation	segmentation	NOUN
fnp-4366	139	12	is	be	AUX
fnp-4366	139	13	used	use	VERB
fnp-4366	139	14	to	to	PART
fnp-4366	139	15	find	find	VERB
fnp-4366	139	16	,	,	PUNCT
fnp-4366	139	17	e.g.	e.g.	ADV
fnp-4366	139	18	,	,	PUNCT
fnp-4366	139	19	immunpositive	immunpositive	ADJ
fnp-4366	139	20	areas	area	NOUN
fnp-4366	139	21	we	we	PRON
fnp-4366	139	22	tried	try	VERB
fnp-4366	139	23	to	to	PART
fnp-4366	139	24	adopt	adopt	VERB
fnp-4366	139	25	the	the	DET
fnp-4366	139	26	algorithms	algorithm	NOUN
fnp-4366	139	27	to	to	ADP
fnp-4366	139	28	the	the	DET
fnp-4366	139	29	traditional	traditional	ADJ
fnp-4366	139	30	concept	concept	NOUN
fnp-4366	139	31	of	of	ADP
fnp-4366	139	32	„	„	PUNCT
fnp-4366	139	33	cellularpathologie	cellularpathologie	NOUN
fnp-4366	139	34	“	"	PUNCT
fnp-4366	139	35	as	as	SCONJ
fnp-4366	139	36	defined	define	VERB
fnp-4366	139	37	by	by	ADP
fnp-4366	139	38	r.	r.	PROPN
fnp-4366	139	39	virchow	virchow	PROPN
fnp-4366	139	40	.	.	PUNCT
fnp-4366	140	1	aims	aim	NOUN
fnp-4366	140	2	:	:	PUNCT
fnp-4366	140	3	we	we	PRON
fnp-4366	140	4	aimed	aim	VERB
fnp-4366	140	5	at	at	ADP
fnp-4366	140	6	optimizing	optimize	VERB
fnp-4366	140	7	existing	exist	VERB
fnp-4366	140	8	image	image	NOUN
fnp-4366	140	9	analysis	analysis	NOUN
fnp-4366	140	10	algorithms	algorithm	NOUN
fnp-4366	140	11	and	and	CCONJ
fnp-4366	140	12	concepts	concept	NOUN
fnp-4366	140	13	specifically	specifically	ADV
fnp-4366	140	14	to	to	ADP
fnp-4366	140	15	the	the	DET
fnp-4366	140	16	need	need	NOUN
fnp-4366	140	17	of	of	ADP
fnp-4366	140	18	classification	classification	NOUN
fnp-4366	140	19	of	of	ADP
fnp-4366	140	20	cells	cell	NOUN
fnp-4366	140	21	on	on	ADP
fnp-4366	140	22	whole	whole	ADJ
fnp-4366	140	23	slide	slide	NOUN
fnp-4366	140	24	images	image	NOUN
fnp-4366	140	25	.	.	PUNCT
fnp-4366	141	1	question	question	NOUN
fnp-4366	141	2	:	:	PUNCT
fnp-4366	141	3	the	the	DET
fnp-4366	141	4	main	main	ADJ
fnp-4366	141	5	question	question	NOUN
fnp-4366	141	6	was	be	AUX
fnp-4366	141	7	to	to	PART
fnp-4366	141	8	determine	determine	VERB
fnp-4366	141	9	a	a	DET
fnp-4366	141	10	workflow	workflow	NOUN
fnp-4366	141	11	which	which	PRON
fnp-4366	141	12	integrates	integrate	VERB
fnp-4366	141	13	on	on	ADP
fnp-4366	141	14	the	the	DET
fnp-4366	141	15	one	one	NUM
fnp-4366	141	16	hand	hand	NOUN
fnp-4366	141	17	the	the	DET
fnp-4366	141	18	needs	need	NOUN
fnp-4366	141	19	of	of	ADP
fnp-4366	141	20	neuropathologists	neuropathologist	NOUN
fnp-4366	141	21	to	to	PART
fnp-4366	141	22	steer	steer	VERB
fnp-4366	141	23	the	the	DET
fnp-4366	141	24	analysis	analysis	NOUN
fnp-4366	141	25	and	and	CCONJ
fnp-4366	141	26	on	on	ADP
fnp-4366	141	27	the	the	DET
fnp-4366	141	28	other	other	ADJ
fnp-4366	141	29	hand	hand	NOUN
fnp-4366	141	30	to	to	PART
fnp-4366	141	31	implement	implement	VERB
fnp-4366	141	32	even	even	ADV
fnp-4366	141	33	advanced	advanced	ADJ
fnp-4366	141	34	computer	computer	NOUN
fnp-4366	141	35	technology	technology	NOUN
fnp-4366	141	36	,	,	PUNCT
fnp-4366	141	37	e.g.	e.g.	ADV
fnp-4366	141	38	,	,	PUNCT
fnp-4366	141	39	with	with	ADP
fnp-4366	141	40	deep	deep	ADJ
fnp-4366	141	41	learning	learning	NOUN
fnp-4366	141	42	-	-	PUNCT
fnp-4366	141	43	based	base	VERB
fnp-4366	141	44	analyses	analysis	NOUN
fnp-4366	141	45	.	.	PUNCT
fnp-4366	142	1	method	method	NOUN
fnp-4366	142	2	:	:	PUNCT
fnp-4366	142	3	our	our	PRON
fnp-4366	142	4	main	main	ADJ
fnp-4366	142	5	method	method	NOUN
fnp-4366	142	6	focused	focus	VERB
fnp-4366	142	7	on	on	ADP
fnp-4366	142	8	supervised	supervised	ADJ
fnp-4366	142	9	deep	deep	ADJ
fnp-4366	142	10	learning	learning	NOUN
fnp-4366	142	11	to	to	PART
fnp-4366	142	12	classify	classify	VERB
fnp-4366	142	13	single	single	ADJ
fnp-4366	142	14	cells	cell	NOUN
fnp-4366	142	15	in	in	ADP
fnp-4366	142	16	immunfluorescence	immunfluorescence	NOUN
fnp-4366	142	17	stainings	staining	NOUN
fnp-4366	142	18	based	base	VERB
fnp-4366	142	19	on	on	ADP
fnp-4366	142	20	existing	exist	VERB
fnp-4366	142	21	nuclear	nuclear	ADJ
fnp-4366	142	22	segmentation	segmentation	NOUN
fnp-4366	142	23	algorithms	algorithm	NOUN
fnp-4366	142	24	.	.	PUNCT
fnp-4366	143	1	result	result	VERB
fnp-4366	143	2	:	:	PUNCT
fnp-4366	143	3	as	as	ADP
fnp-4366	143	4	a	a	DET
fnp-4366	143	5	result	result	NOUN
fnp-4366	143	6	we	we	PRON
fnp-4366	143	7	deployed	deploy	VERB
fnp-4366	143	8	locally	locally	ADV
fnp-4366	143	9	an	an	DET
fnp-4366	143	10	image	image	NOUN
fnp-4366	143	11	classification	classification	NOUN
fnp-4366	143	12	server	server	NOUN
fnp-4366	143	13	for	for	ADP
fnp-4366	143	14	cell	cell	NOUN
fnp-4366	143	15	annotation	annotation	NOUN
fnp-4366	143	16	by	by	ADP
fnp-4366	143	17	neuropathological	neuropathological	ADJ
fnp-4366	143	18	experts	expert	NOUN
fnp-4366	143	19	without	without	ADP
fnp-4366	143	20	background	background	NOUN
fnp-4366	143	21	in	in	ADP
fnp-4366	143	22	computer	computer	NOUN
fnp-4366	143	23	science	science	NOUN
fnp-4366	143	24	in	in	ADP
fnp-4366	143	25	combination	combination	NOUN
fnp-4366	143	26	with	with	ADP
fnp-4366	143	27	an	an	DET
fnp-4366	143	28	open	open	ADJ
fnp-4366	143	29	microscopy	microscopy	NOUN
fnp-4366	143	30	(	(	PUNCT
fnp-4366	143	31	omero	omero	NOUN
fnp-4366	143	32	)	)	PUNCT
fnp-4366	143	33	server	server	NOUN
fnp-4366	143	34	.	.	PUNCT
fnp-4366	144	1	manually	manually	ADV
fnp-4366	144	2	annotated	annotate	VERB
fnp-4366	144	3	images	image	NOUN
fnp-4366	144	4	were	be	AUX
fnp-4366	144	5	used	use	VERB
fnp-4366	144	6	to	to	PART
fnp-4366	144	7	train	train	VERB
fnp-4366	144	8	various	various	ADJ
fnp-4366	144	9	classification	classification	NOUN
fnp-4366	144	10	algorithms	algorithm	NOUN
fnp-4366	144	11	in	in	ADP
fnp-4366	144	12	combination	combination	NOUN
fnp-4366	144	13	with	with	ADP
fnp-4366	144	14	data	datum	NOUN
fnp-4366	144	15	augmentation	augmentation	NOUN
fnp-4366	144	16	and	and	CCONJ
fnp-4366	144	17	other	other	ADJ
fnp-4366	144	18	techniques	technique	NOUN
fnp-4366	144	19	to	to	PART
fnp-4366	144	20	optimize	optimize	VERB
fnp-4366	144	21	performance	performance	NOUN
fnp-4366	144	22	.	.	PUNCT
fnp-4366	145	1	after	after	ADP
fnp-4366	145	2	model	model	NOUN
fnp-4366	145	3	selection	selection	NOUN
fnp-4366	145	4	we	we	PRON
fnp-4366	145	5	could	could	AUX
fnp-4366	145	6	reach	reach	VERB
fnp-4366	145	7	almost	almost	ADV
fnp-4366	145	8	human	human	ADJ
fnp-4366	145	9	performance	performance	NOUN
fnp-4366	145	10	(	(	PUNCT
fnp-4366	145	11	>	>	SYM
fnp-4366	145	12	98	98	NUM
fnp-4366	145	13	%	%	NOUN
fnp-4366	145	14	accuracy	accuracy	NOUN
fnp-4366	145	15	with	with	ADP
fnp-4366	145	16	<	<	X
fnp-4366	145	17	2	2	NUM
fnp-4366	145	18	-	-	SYM
fnp-4366	145	19	3	3	NUM
fnp-4366	145	20	%	%	NOUN
fnp-4366	145	21	false	false	ADJ
fnp-4366	145	22	positive	positive	ADJ
fnp-4366	145	23	rate	rate	NOUN
fnp-4366	145	24	)	)	PUNCT
fnp-4366	145	25	in	in	ADP
fnp-4366	145	26	an	an	DET
fnp-4366	145	27	exemplary	exemplary	ADJ
fnp-4366	145	28	project	project	NOUN
fnp-4366	145	29	of	of	ADP
fnp-4366	145	30	microglial	microglial	ADJ
fnp-4366	145	31	cell	cell	NOUN
fnp-4366	145	32	classification	classification	NOUN
fnp-4366	145	33	stained	stain	VERB
fnp-4366	145	34	by	by	ADP
fnp-4366	145	35	iba1	iba1	PROPN
fnp-4366	145	36	.	.	PUNCT
fnp-4366	146	1	conclusion	conclusion	NOUN
fnp-4366	146	2	:	:	PUNCT
fnp-4366	146	3	we	we	PRON
fnp-4366	146	4	conclude	conclude	VERB
fnp-4366	146	5	that	that	SCONJ
fnp-4366	146	6	this	this	DET
fnp-4366	146	7	concept	concept	NOUN
fnp-4366	146	8	of	of	ADP
fnp-4366	146	9	image	image	NOUN
fnp-4366	146	10	analysis	analysis	NOUN
fnp-4366	146	11	generalizes	generalize	VERB
fnp-4366	146	12	to	to	ADP
fnp-4366	146	13	various	various	ADJ
fnp-4366	146	14	sorts	sort	NOUN
fnp-4366	146	15	of	of	ADP
fnp-4366	146	16	immunfluorescence	immunfluorescence	NOUN
fnp-4366	146	17	stainings	staining	NOUN
fnp-4366	146	18	and	and	CCONJ
fnp-4366	146	19	might	might	AUX
fnp-4366	146	20	thus	thus	ADV
fnp-4366	146	21	help	help	VERB
fnp-4366	146	22	to	to	PART
fnp-4366	146	23	elevate	elevate	VERB
fnp-4366	146	24	the	the	DET
fnp-4366	146	25	single	single	ADJ
fnp-4366	146	26	cellular	cellular	ADJ
fnp-4366	146	27	analysis	analysis	NOUN
fnp-4366	146	28	to	to	ADP
fnp-4366	146	29	a	a	DET
fnp-4366	146	30	whole	whole	ADJ
fnp-4366	146	31	tissue	tissue	NOUN
fnp-4366	146	32	-	-	PUNCT
fnp-4366	146	33	based	base	VERB
fnp-4366	146	34	analysis	analysis	NOUN
fnp-4366	146	35	with	with	ADP
fnp-4366	146	36	millions	million	NOUN
fnp-4366	146	37	of	of	ADP
fnp-4366	146	38	cells	cell	NOUN
fnp-4366	146	39	.	.	PUNCT
fnp-4366	146	40	  	  	SPACE
fnp-4366	147	1	2	2	NUM
fnp-4366	147	2	.	.	PUNCT
fnp-4366	147	3	neuroonocology	neuroonocology	NOUN
fnp-4366	147	4	2.01	2.01	NUM
fnp-4366	147	5	free	free	ADJ
fnp-4366	147	6	neuropathol	neuropathol	NOUN
fnp-4366	147	7	3:20:17	3:20:17	NUM
fnp-4366	147	8	using	use	VERB
fnp-4366	147	9	spatial	spatial	ADJ
fnp-4366	147	10	transciptomics	transciptomic	NOUN
fnp-4366	147	11	for	for	ADP
fnp-4366	147	12	diagnostic	diagnostic	ADJ
fnp-4366	147	13	analysis	analysis	NOUN
fnp-4366	147	14	of	of	ADP
fnp-4366	147	15	glioma	glioma	NOUN
fnp-4366	147	16	michael	michael	PROPN
fnp-4366	147	17	ritter1,2	ritter1,2	PROPN
fnp-4366	147	18	,	,	PUNCT
fnp-4366	147	19	christina	christina	PROPN
fnp-4366	147	20	blume1,2	blume1,2	PROPN
fnp-4366	147	21	,	,	PUNCT
fnp-4366	147	22	areeba	areeba	PROPN
fnp-4366	147	23	patel1,2	patel1,2	PROPN
fnp-4366	147	24	,	,	PUNCT
fnp-4366	147	25	philipp	philipp	PROPN
fnp-4366	147	26	sievers1,2	sievers1,2	PROPN
fnp-4366	147	27	,	,	PUNCT
fnp-4366	147	28	helin	helin	PROPN
fnp-4366	147	29	dogan1,2	dogan1,2	PROPN
fnp-4366	147	30	,	,	PUNCT
fnp-4366	147	31	christel	christel	PROPN
fnp-4366	147	32	herold	herold	PROPN
fnp-4366	147	33	-	-	PUNCT
fnp-4366	147	34	mende3	mende3	PROPN
fnp-4366	147	35	,	,	PUNCT
fnp-4366	147	36	wolfgang	wolfgang	PROPN
fnp-4366	147	37	wick4,5,6	wick4,5,6	PROPN
fnp-4366	147	38	,	,	PUNCT
fnp-4366	147	39	andreas	andreas	PROPN
fnp-4366	147	40	von	von	PROPN
fnp-4366	147	41	deimling1,2	deimling1,2	PROPN
fnp-4366	147	42	,	,	PUNCT
fnp-4366	147	43	felix	felix	PROPN
fnp-4366	147	44	sahm1,2	sahm1,2	PROPN
fnp-4366	147	45	1	1	NUM
fnp-4366	147	46	university	university	NOUN
fnp-4366	147	47	hospital	hospital	NOUN
fnp-4366	147	48	heidelberg	heidelberg	PROPN
fnp-4366	147	49	,	,	PUNCT
fnp-4366	147	50	department	department	NOUN
fnp-4366	147	51	of	of	ADP
fnp-4366	147	52	neuropathology	neuropathology	NOUN
fnp-4366	147	53	,	,	PUNCT
fnp-4366	147	54	heidelberg	heidelberg	PROPN
fnp-4366	147	55	,	,	PUNCT
fnp-4366	147	56	deutschland	deutschland	NOUN
fnp-4366	147	57	2	2	NUM
fnp-4366	147	58	german	german	ADJ
fnp-4366	147	59	cancer	cancer	NOUN
fnp-4366	147	60	research	research	NOUN
fnp-4366	147	61	center	center	NOUN
fnp-4366	147	62	(	(	PUNCT
fnp-4366	147	63	dkfz	dkfz	PROPN
fnp-4366	147	64	)	)	PUNCT
fnp-4366	147	65	,	,	PUNCT
fnp-4366	147	66	german	german	ADJ
fnp-4366	147	67	consortium	consortium	NOUN
fnp-4366	147	68	for	for	ADP
fnp-4366	147	69	translational	translational	ADJ
fnp-4366	147	70	cancer	cancer	NOUN
fnp-4366	147	71	research	research	NOUN
fnp-4366	147	72	(	(	PUNCT
fnp-4366	147	73	dktk	dktk	NOUN
fnp-4366	147	74	)	)	PUNCT
fnp-4366	147	75	,	,	PUNCT
fnp-4366	147	76	clinical	clinical	ADJ
fnp-4366	147	77	cooperation	cooperation	NOUN
fnp-4366	147	78	unit	unit	NOUN
fnp-4366	147	79	neuropathology	neuropathology	NOUN
fnp-4366	147	80	,	,	PUNCT
fnp-4366	147	81	heidelberg	heidelberg	PROPN
fnp-4366	147	82	,	,	PUNCT
fnp-4366	147	83	deutschland	deutschland	NOUN
fnp-4366	147	84	3	3	NUM
fnp-4366	147	85	university	university	NOUN
fnp-4366	147	86	hospital	hospital	NOUN
fnp-4366	147	87	heidelberg	heidelberg	PROPN
fnp-4366	147	88	,	,	PUNCT
fnp-4366	147	89	department	department	NOUN
fnp-4366	147	90	of	of	ADP
fnp-4366	147	91	neurosurgery	neurosurgery	NOUN
fnp-4366	147	92	,	,	PUNCT
fnp-4366	147	93	heidelberg	heidelberg	NOUN
fnp-4366	147	94	,	,	PUNCT
fnp-4366	147	95	deutschland	deutschland	NOUN
fnp-4366	147	96	4	4	NUM
fnp-4366	147	97	german	german	ADJ
fnp-4366	147	98	cancer	cancer	NOUN
fnp-4366	147	99	research	research	NOUN
fnp-4366	147	100	center	center	NOUN
fnp-4366	147	101	(	(	PUNCT
fnp-4366	147	102	dkfz	dkfz	PROPN
fnp-4366	147	103	)	)	PUNCT
fnp-4366	147	104	,	,	PUNCT
fnp-4366	147	105	german	german	ADJ
fnp-4366	147	106	consortium	consortium	NOUN
fnp-4366	147	107	for	for	ADP
fnp-4366	147	108	translational	translational	ADJ
fnp-4366	147	109	cancer	cancer	NOUN
fnp-4366	147	110	research	research	NOUN
fnp-4366	147	111	(	(	PUNCT
fnp-4366	147	112	dktk	dktk	NOUN
fnp-4366	147	113	)	)	PUNCT
fnp-4366	147	114	,	,	PUNCT
fnp-4366	147	115	clinical	clinical	ADJ
fnp-4366	147	116	cooperation	cooperation	NOUN
fnp-4366	147	117	unit	unit	NOUN
fnp-4366	147	118	neurooncology	neurooncology	PROPN
fnp-4366	147	119	,	,	PUNCT
fnp-4366	147	120	heidelberg	heidelberg	PROPN
fnp-4366	147	121	,	,	PUNCT
fnp-4366	147	122	deutschland	deutschland	NOUN
fnp-4366	147	123	5	5	NUM
fnp-4366	147	124	university	university	NOUN
fnp-4366	147	125	hospital	hospital	NOUN
fnp-4366	147	126	heidelberg	heidelberg	PROPN
fnp-4366	147	127	,	,	PUNCT
fnp-4366	147	128	neurology	neurology	NOUN
fnp-4366	147	129	clinic	clinic	PROPN
fnp-4366	147	130	,	,	PUNCT
fnp-4366	147	131	heidelberg	heidelberg	PROPN
fnp-4366	147	132	,	,	PUNCT
fnp-4366	147	133	deutschland	deutschland	NOUN
fnp-4366	147	134	6	6	NUM
fnp-4366	147	135	german	german	ADJ
fnp-4366	147	136	cancer	cancer	NOUN
fnp-4366	147	137	research	research	NOUN
fnp-4366	147	138	center	center	NOUN
fnp-4366	147	139	(	(	PUNCT
fnp-4366	147	140	dkfz	dkfz	PROPN
fnp-4366	147	141	)	)	PUNCT
fnp-4366	147	142	,	,	PUNCT
fnp-4366	147	143	national	national	ADJ
fnp-4366	147	144	center	center	NOUN
fnp-4366	147	145	for	for	ADP
fnp-4366	147	146	tumor	tumor	NOUN
fnp-4366	147	147	diseases	disease	NOUN
fnp-4366	147	148	(	(	PUNCT
fnp-4366	147	149	nct	nct	NOUN
fnp-4366	147	150	)	)	PUNCT
fnp-4366	147	151	,	,	PUNCT
fnp-4366	147	152	department	department	NOUN
fnp-4366	147	153	of	of	ADP
fnp-4366	147	154	neurology	neurology	NOUN
fnp-4366	147	155	and	and	CCONJ
fnp-4366	147	156	neurooncology	neurooncology	NOUN
fnp-4366	147	157	program	program	NOUN
fnp-4366	147	158	,	,	PUNCT
fnp-4366	147	159	heidelberg	heidelberg	PROPN
fnp-4366	147	160	,	,	PUNCT
fnp-4366	147	161	deutschland	deutschland	NOUN
fnp-4366	147	162	background	background	NOUN
fnp-4366	147	163	:	:	PUNCT
fnp-4366	147	164	the	the	DET
fnp-4366	147	165	lack	lack	NOUN
fnp-4366	147	166	of	of	ADP
fnp-4366	147	167	specific	specific	ADJ
fnp-4366	147	168	in	in	ADP
fnp-4366	147	169	-	-	PUNCT
fnp-4366	147	170	situ	situ	NOUN
fnp-4366	147	171	markers	marker	NOUN
fnp-4366	147	172	of	of	ADP
fnp-4366	147	173	idh	idh	NOUN
fnp-4366	147	174	-	-	PUNCT
fnp-4366	147	175	wildtype	wildtype	NOUN
fnp-4366	147	176	glioblastoma	glioblastoma	NOUN
fnp-4366	147	177	makes	make	VERB
fnp-4366	147	178	it	it	PRON
fnp-4366	147	179	hard	hard	ADJ
fnp-4366	147	180	to	to	PART
fnp-4366	147	181	distinguish	distinguish	VERB
fnp-4366	147	182	between	between	ADP
fnp-4366	147	183	infiltrating	infiltrate	VERB
fnp-4366	147	184	tumour	tumour	ADJ
fnp-4366	147	185	cells	cell	NOUN
fnp-4366	147	186	and	and	CCONJ
fnp-4366	147	187	reactive	reactive	ADJ
fnp-4366	147	188	tissue	tissue	NOUN
fnp-4366	147	189	.	.	PUNCT
fnp-4366	148	1	determination	determination	NOUN
fnp-4366	148	2	of	of	ADP
fnp-4366	148	3	copy	copy	NOUN
fnp-4366	148	4	number	number	NOUN
fnp-4366	148	5	variations	variation	NOUN
fnp-4366	148	6	(	(	PUNCT
fnp-4366	148	7	cnv	cnv	NOUN
fnp-4366	148	8	)	)	PUNCT
fnp-4366	148	9	of	of	ADP
fnp-4366	148	10	chromosomes	chromosome	NOUN
fnp-4366	148	11	may	may	AUX
fnp-4366	148	12	assist	assist	VERB
fnp-4366	148	13	in	in	ADP
fnp-4366	148	14	this	this	DET
fnp-4366	148	15	diagnostic	diagnostic	ADJ
fnp-4366	148	16	challenge	challenge	NOUN
fnp-4366	148	17	,	,	PUNCT
fnp-4366	148	18	but	but	CCONJ
fnp-4366	148	19	often	often	ADV
fnp-4366	148	20	requires	require	VERB
fnp-4366	148	21	a	a	DET
fnp-4366	148	22	large	large	ADJ
fnp-4366	148	23	amount	amount	NOUN
fnp-4366	148	24	of	of	ADP
fnp-4366	148	25	tissue	tissue	NOUN
fnp-4366	148	26	,	,	PUNCT
fnp-4366	148	27	which	which	PRON
fnp-4366	148	28	is	be	AUX
fnp-4366	148	29	not	not	PART
fnp-4366	148	30	always	always	ADV
fnp-4366	148	31	available	available	ADJ
fnp-4366	148	32	.	.	PUNCT
fnp-4366	149	1	especially	especially	ADV
fnp-4366	149	2	for	for	ADP
fnp-4366	149	3	stereotactic	stereotactic	ADJ
fnp-4366	149	4	biopsies	biopsy	NOUN
fnp-4366	149	5	the	the	DET
fnp-4366	149	6	available	available	ADJ
fnp-4366	149	7	material	material	NOUN
fnp-4366	149	8	is	be	AUX
fnp-4366	149	9	often	often	ADV
fnp-4366	149	10	quite	quite	ADV
fnp-4366	149	11	limited	limited	ADJ
fnp-4366	149	12	.	.	PUNCT
fnp-4366	150	1	aims	aim	NOUN
fnp-4366	150	2	:	:	PUNCT
fnp-4366	150	3	in	in	ADP
fnp-4366	150	4	our	our	PRON
fnp-4366	150	5	study	study	NOUN
fnp-4366	150	6	we	we	PRON
fnp-4366	150	7	wanted	want	VERB
fnp-4366	150	8	to	to	PART
fnp-4366	150	9	test	test	VERB
fnp-4366	150	10	the	the	DET
fnp-4366	150	11	feasibility	feasibility	NOUN
fnp-4366	150	12	of	of	ADP
fnp-4366	150	13	using	use	VERB
fnp-4366	150	14	spatial	spatial	ADJ
fnp-4366	150	15	transcriptomics	transcriptomic	NOUN
fnp-4366	150	16	to	to	PART
fnp-4366	150	17	distinguish	distinguish	VERB
fnp-4366	150	18	between	between	ADP
fnp-4366	150	19	invading	invade	VERB
fnp-4366	150	20	tumour	tumour	ADJ
fnp-4366	150	21	cells	cell	NOUN
fnp-4366	150	22	and	and	CCONJ
fnp-4366	150	23	reactive	reactive	ADJ
fnp-4366	150	24	/	/	SYM
fnp-4366	150	25	adjacent	adjacent	ADJ
fnp-4366	150	26	tissue	tissue	NOUN
fnp-4366	151	1	and	and	CCONJ
fnp-4366	151	2	if	if	SCONJ
fnp-4366	151	3	it	it	PRON
fnp-4366	151	4	is	be	AUX
fnp-4366	151	5	possible	possible	ADJ
fnp-4366	151	6	to	to	PART
fnp-4366	151	7	generate	generate	VERB
fnp-4366	151	8	useful	useful	ADJ
fnp-4366	151	9	data	datum	NOUN
fnp-4366	151	10	like	like	ADP
fnp-4366	151	11	cnvs	cnvs	NOUN
fnp-4366	151	12	from	from	ADP
fnp-4366	151	13	small	small	ADJ
fnp-4366	151	14	tissue	tissue	NOUN
fnp-4366	151	15	fragments	fragment	NOUN
fnp-4366	151	16	.	.	PUNCT
fnp-4366	152	1	methods	method	NOUN
fnp-4366	152	2	:	:	PUNCT
fnp-4366	152	3	we	we	PRON
fnp-4366	152	4	applied	apply	VERB
fnp-4366	152	5	spatial	spatial	ADJ
fnp-4366	152	6	transcriptomics	transcriptomic	NOUN
fnp-4366	152	7	on	on	ADP
fnp-4366	152	8	12	12	NUM
fnp-4366	152	9	ffpe	ffpe	NOUN
fnp-4366	152	10	gbm	gbm	NOUN
fnp-4366	152	11	samples	sample	NOUN
fnp-4366	152	12	indicating	indicate	VERB
fnp-4366	152	13	reactive	reactive	ADJ
fnp-4366	152	14	tissue	tissue	NOUN
fnp-4366	152	15	or	or	CCONJ
fnp-4366	152	16	an	an	DET
fnp-4366	152	17	infiltration	infiltration	NOUN
fnp-4366	152	18	zone	zone	NOUN
fnp-4366	152	19	and	and	CCONJ
fnp-4366	152	20	4	4	NUM
fnp-4366	152	21	stereotactic	stereotactic	ADJ
fnp-4366	152	22	biopsies	biopsy	NOUN
fnp-4366	152	23	.	.	PUNCT
fnp-4366	153	1	we	we	PRON
fnp-4366	153	2	determined	determine	VERB
fnp-4366	153	3	the	the	DET
fnp-4366	153	4	cnv	cnv	NOUN
fnp-4366	153	5	for	for	ADP
fnp-4366	153	6	all	all	DET
fnp-4366	153	7	samples	sample	NOUN
fnp-4366	153	8	and	and	CCONJ
fnp-4366	153	9	used	use	VERB
fnp-4366	153	10	a	a	DET
fnp-4366	153	11	single	single	ADJ
fnp-4366	153	12	cell	cell	NOUN
fnp-4366	153	13	dataset	dataset	NOUN
fnp-4366	153	14	of	of	ADP
fnp-4366	153	15	infiltrating	infiltrate	VERB
fnp-4366	153	16	tumour	tumour	ADJ
fnp-4366	153	17	cells	cell	NOUN
fnp-4366	153	18	(	(	PUNCT
fnp-4366	153	19	darmanis	darmani	NOUN
fnp-4366	153	20	et	et	PROPN
fnp-4366	153	21	al	al	PROPN
fnp-4366	153	22	.	.	PROPN
fnp-4366	153	23	,	,	PUNCT
fnp-4366	153	24	2017	2017	NUM
fnp-4366	153	25	)	)	PUNCT
fnp-4366	153	26	to	to	PART
fnp-4366	153	27	map	map	VERB
fnp-4366	153	28	the	the	DET
fnp-4366	153	29	different	different	ADJ
fnp-4366	153	30	cell	cell	NOUN
fnp-4366	153	31	types	type	NOUN
fnp-4366	153	32	onto	onto	ADP
fnp-4366	153	33	the	the	DET
fnp-4366	153	34	tissue	tissue	NOUN
fnp-4366	153	35	.	.	PUNCT
fnp-4366	154	1	results	result	NOUN
fnp-4366	154	2	:	:	PUNCT
fnp-4366	154	3	the	the	DET
fnp-4366	154	4	mapping	mapping	NOUN
fnp-4366	154	5	of	of	ADP
fnp-4366	154	6	the	the	DET
fnp-4366	154	7	tumour	tumour	NOUN
fnp-4366	154	8	cells	cell	NOUN
fnp-4366	154	9	onto	onto	ADP
fnp-4366	154	10	the	the	DET
fnp-4366	154	11	sections	section	NOUN
fnp-4366	154	12	clearly	clearly	ADV
fnp-4366	154	13	distinguished	distinguish	VERB
fnp-4366	154	14	the	the	DET
fnp-4366	154	15	tumour	tumour	NOUN
fnp-4366	154	16	from	from	ADP
fnp-4366	154	17	the	the	DET
fnp-4366	154	18	adjacent	adjacent	ADJ
fnp-4366	154	19	tissue	tissue	NOUN
fnp-4366	154	20	and	and	CCONJ
fnp-4366	154	21	also	also	ADV
fnp-4366	154	22	allowed	allow	VERB
fnp-4366	154	23	to	to	PART
fnp-4366	154	24	further	far	ADV
fnp-4366	154	25	distinguish	distinguish	VERB
fnp-4366	154	26	between	between	ADP
fnp-4366	154	27	majorly	majorly	ADV
fnp-4366	154	28	reactive	reactive	ADJ
fnp-4366	154	29	tissue	tissue	NOUN
fnp-4366	154	30	and	and	CCONJ
fnp-4366	154	31	tissue	tissue	NOUN
fnp-4366	154	32	with	with	ADP
fnp-4366	154	33	a	a	DET
fnp-4366	154	34	high	high	ADJ
fnp-4366	154	35	number	number	NOUN
fnp-4366	154	36	of	of	ADP
fnp-4366	154	37	infiltrating	infiltrate	VERB
fnp-4366	154	38	tumour	tumour	ADJ
fnp-4366	154	39	cells	cell	NOUN
fnp-4366	154	40	.	.	PUNCT
fnp-4366	155	1	nevertheless	nevertheless	ADV
fnp-4366	155	2	,	,	PUNCT
fnp-4366	155	3	mapping	mapping	NOUN
fnp-4366	155	4	on	on	ADP
fnp-4366	155	5	single	single	ADJ
fnp-4366	155	6	cell	cell	NOUN
fnp-4366	155	7	level	level	NOUN
fnp-4366	155	8	resolution	resolution	NOUN
fnp-4366	155	9	requires	require	VERB
fnp-4366	155	10	higher	high	ADJ
fnp-4366	155	11	resolution	resolution	NOUN
fnp-4366	155	12	methods	method	NOUN
fnp-4366	155	13	.	.	PUNCT
fnp-4366	156	1	both	both	DET
fnp-4366	156	2	mapping	mapping	NOUN
fnp-4366	156	3	by	by	ADP
fnp-4366	156	4	chr	chr	PROPN
fnp-4366	156	5	.	.	PROPN
fnp-4366	156	6	7	7	NUM
fnp-4366	156	7	gain	gain	NOUN
fnp-4366	156	8	and	and	CCONJ
fnp-4366	156	9	chr	chr	PROPN
fnp-4366	156	10	.	.	PROPN
fnp-4366	156	11	10	10	NUM
fnp-4366	156	12	loss	loss	NOUN
fnp-4366	156	13	and	and	CCONJ
fnp-4366	156	14	expression	expression	NOUN
fnp-4366	156	15	-	-	PUNCT
fnp-4366	156	16	based	base	VERB
fnp-4366	156	17	mapping	mapping	NOUN
fnp-4366	156	18	produced	produce	VERB
fnp-4366	156	19	similar	similar	ADJ
fnp-4366	156	20	results	result	NOUN
fnp-4366	156	21	.	.	PUNCT
fnp-4366	157	1	using	use	VERB
fnp-4366	157	2	spatial	spatial	ADJ
fnp-4366	157	3	transcriptomics	transcriptomic	NOUN
fnp-4366	157	4	on	on	ADP
fnp-4366	157	5	stereotactic	stereotactic	ADJ
fnp-4366	157	6	biopsies	biopsy	NOUN
fnp-4366	157	7	we	we	PRON
fnp-4366	157	8	were	be	AUX
fnp-4366	157	9	able	able	ADJ
fnp-4366	157	10	to	to	PART
fnp-4366	157	11	determine	determine	VERB
fnp-4366	157	12	the	the	DET
fnp-4366	157	13	major	major	ADJ
fnp-4366	157	14	cnvs	cnvs	NOUN
fnp-4366	157	15	from	from	ADP
fnp-4366	157	16	a	a	DET
fnp-4366	157	17	5	5	NUM
fnp-4366	157	18	µm	µm	ADP
fnp-4366	157	19	thick	thick	ADJ
fnp-4366	157	20	tissue	tissue	NOUN
fnp-4366	157	21	section	section	NOUN
fnp-4366	157	22	with	with	ADP
fnp-4366	157	23	a	a	DET
fnp-4366	157	24	1	1	NUM
fnp-4366	157	25	mm	mm	NOUN
fnp-4366	157	26	diameter	diameter	NOUN
fnp-4366	157	27	.	.	PUNCT
fnp-4366	158	1	conclusion	conclusion	NOUN
fnp-4366	158	2	:	:	PUNCT
fnp-4366	158	3	in	in	ADP
fnp-4366	158	4	summary	summary	NOUN
fnp-4366	158	5	we	we	PRON
fnp-4366	158	6	prove	prove	VERB
fnp-4366	158	7	the	the	DET
fnp-4366	158	8	feasibility	feasibility	NOUN
fnp-4366	158	9	to	to	PART
fnp-4366	158	10	identify	identify	VERB
fnp-4366	158	11	the	the	DET
fnp-4366	158	12	infiltration	infiltration	NOUN
fnp-4366	158	13	zone	zone	NOUN
fnp-4366	158	14	and	and	CCONJ
fnp-4366	158	15	distinguish	distinguish	VERB
fnp-4366	158	16	from	from	ADP
fnp-4366	158	17	reactive	reactive	ADJ
fnp-4366	158	18	tissue	tissue	NOUN
fnp-4366	158	19	using	use	VERB
fnp-4366	158	20	spatial	spatial	ADJ
fnp-4366	158	21	transcriptomics	transcriptomic	NOUN
fnp-4366	158	22	,	,	PUNCT
fnp-4366	158	23	and	and	CCONJ
fnp-4366	158	24	we	we	PRON
fnp-4366	158	25	were	be	AUX
fnp-4366	158	26	able	able	ADJ
fnp-4366	158	27	to	to	PART
fnp-4366	158	28	derive	derive	VERB
fnp-4366	158	29	cnv	cnv	PROPN
fnp-4366	158	30	from	from	ADP
fnp-4366	158	31	very	very	ADV
fnp-4366	158	32	small	small	ADJ
fnp-4366	158	33	tissue	tissue	NOUN
fnp-4366	158	34	fractions	fraction	NOUN
fnp-4366	158	35	.	.	PUNCT
fnp-4366	159	1	this	this	PRON
fnp-4366	159	2	can	can	AUX
fnp-4366	159	3	be	be	AUX
fnp-4366	159	4	leveraged	leverage	VERB
fnp-4366	159	5	especially	especially	ADV
fnp-4366	159	6	if	if	SCONJ
fnp-4366	159	7	immunohistochemical	immunohistochemical	ADJ
fnp-4366	159	8	stainings	staining	NOUN
fnp-4366	159	9	are	be	AUX
fnp-4366	159	10	not	not	PART
fnp-4366	159	11	informative	informative	ADJ
fnp-4366	159	12	or	or	CCONJ
fnp-4366	159	13	too	too	ADV
fnp-4366	159	14	little	little	ADJ
fnp-4366	159	15	tissue	tissue	NOUN
fnp-4366	159	16	is	be	AUX
fnp-4366	159	17	left	leave	VERB
fnp-4366	159	18	for	for	ADP
fnp-4366	159	19	the	the	DET
fnp-4366	159	20	determination	determination	NOUN
fnp-4366	159	21	of	of	ADP
fnp-4366	159	22	cnv	cnv	PROPN
fnp-4366	159	23	profiles	profile	NOUN
fnp-4366	159	24	.	.	PUNCT
fnp-4366	159	25	  	  	SPACE
fnp-4366	159	26	2.02	2.02	NUM
fnp-4366	159	27	free	free	ADJ
fnp-4366	159	28	neuropathol	neuropathol	NOUN
fnp-4366	159	29	3:20:18	3:20:18	NUM
fnp-4366	159	30	single	single	ADJ
fnp-4366	159	31	cell	cell	NOUN
fnp-4366	159	32	dna	dna	NOUN
fnp-4366	159	33	amplicon	amplicon	NOUN
fnp-4366	159	34	sequencing	sequencing	NOUN
fnp-4366	159	35	reveals	reveal	VERB
fnp-4366	159	36	order	order	NOUN
fnp-4366	159	37	of	of	ADP
fnp-4366	159	38	mutational	mutational	ADJ
fnp-4366	159	39	acquisition	acquisition	NOUN
fnp-4366	159	40	in	in	ADP
fnp-4366	159	41	traf7	traf7	PROPN
fnp-4366	159	42	and	and	CCONJ
fnp-4366	159	43	klf4	klf4	PROPN
fnp-4366	159	44	or	or	CCONJ
fnp-4366	159	45	akt1	akt1	PROPN
fnp-4366	159	46	co	co	VERB
fnp-4366	159	47	-	-	VERB
fnp-4366	159	48	mutated	mutate	VERB
fnp-4366	159	49	meningiomas	meningiomas	PROPN
fnp-4366	159	50	helin	helin	PROPN
fnp-4366	159	51	dogan1	dogan1	PROPN
fnp-4366	159	52	,	,	PUNCT
fnp-4366	159	53	christina	christina	PROPN
fnp-4366	159	54	blume1	blume1	NOUN
fnp-4366	159	55	,	,	PUNCT
fnp-4366	159	56	areeba	areeba	PROPN
fnp-4366	159	57	patel1	patel1	NOUN
fnp-4366	159	58	,	,	PUNCT
fnp-4366	159	59	gerhard	gerhard	PROPN
fnp-4366	159	60	jungwirth2	jungwirth2	PROPN
fnp-4366	159	61	,	,	PUNCT
fnp-4366	159	62	miriam	miriam	PROPN
fnp-4366	159	63	ratliff3	ratliff3	PROPN
fnp-4366	159	64	,	,	PUNCT
fnp-4366	159	65	ralf	ralf	PROPN
fnp-4366	159	66	ketter4	ketter4	PROPN
fnp-4366	159	67	,	,	PUNCT
fnp-4366	159	68	wolfgang	wolfgang	PROPN
fnp-4366	159	69	wick5	wick5	PROPN
fnp-4366	159	70	,	,	PUNCT
fnp-4366	159	71	christel	christel	PROPN
fnp-4366	159	72	herold	herold	PROPN
fnp-4366	159	73	-	-	PUNCT
fnp-4366	159	74	mende2	mende2	PROPN
fnp-4366	159	75	,	,	PUNCT
fnp-4366	159	76	david	david	PROPN
fnp-4366	159	77	reuss1	reuss1	PROPN
fnp-4366	159	78	,	,	PUNCT
fnp-4366	159	79	andreas	andreas	PROPN
fnp-4366	159	80	von	von	PROPN
fnp-4366	159	81	deimling1	deimling1	PROPN
fnp-4366	159	82	,	,	PUNCT
fnp-4366	159	83	felix	felix	PROPN
fnp-4366	159	84	sahm1	sahm1	NOUN
fnp-4366	159	85	1	1	NUM
fnp-4366	159	86	clinical	clinical	ADJ
fnp-4366	159	87	cooperation	cooperation	NOUN
fnp-4366	159	88	unit	unit	NOUN
fnp-4366	159	89	neuropathology	neuropathology	NOUN
fnp-4366	159	90	,	,	PUNCT
fnp-4366	159	91	german	german	ADJ
fnp-4366	159	92	cancer	cancer	NOUN
fnp-4366	159	93	consortium	consortium	NOUN
fnp-4366	159	94	(	(	PUNCT
fnp-4366	159	95	dktk	dktk	NOUN
fnp-4366	159	96	)	)	PUNCT
fnp-4366	159	97	,	,	PUNCT
fnp-4366	159	98	german	german	ADJ
fnp-4366	159	99	cancer	cancer	NOUN
fnp-4366	159	100	research	research	NOUN
fnp-4366	159	101	center	center	NOUN
fnp-4366	159	102	and	and	CCONJ
fnp-4366	159	103	dept	dept	NOUN
fnp-4366	159	104	.	.	PROPN
fnp-4366	159	105	of	of	ADP
fnp-4366	159	106	neuropathology	neuropathology	NOUN
fnp-4366	159	107	,	,	PUNCT
fnp-4366	159	108	university	university	NOUN
fnp-4366	159	109	hospital	hospital	NOUN
fnp-4366	159	110	heidelberg	heidelberg	PROPN
fnp-4366	159	111	,	,	PUNCT
fnp-4366	159	112	heidelberg	heidelberg	PROPN
fnp-4366	159	113	,	,	PUNCT
fnp-4366	159	114	deutschland	deutschland	NOUN
fnp-4366	159	115	2	2	NUM
fnp-4366	159	116	dept	dept	NOUN
fnp-4366	159	117	.	.	PROPN
fnp-4366	160	1	of	of	ADP
fnp-4366	160	2	neurosurgery	neurosurgery	NOUN
fnp-4366	160	3	,	,	PUNCT
fnp-4366	160	4	university	university	NOUN
fnp-4366	160	5	hospital	hospital	NOUN
fnp-4366	160	6	heidelberg	heidelberg	PROPN
fnp-4366	160	7	,	,	PUNCT
fnp-4366	160	8	heidelberg	heidelberg	PROPN
fnp-4366	160	9	,	,	PUNCT
fnp-4366	160	10	deutschland	deutschland	NOUN
fnp-4366	160	11	3	3	NUM
fnp-4366	160	12	dept	dept	NOUN
fnp-4366	160	13	.	.	PROPN
fnp-4366	161	1	of	of	ADP
fnp-4366	161	2	neurosurgery	neurosurgery	NOUN
fnp-4366	161	3	,	,	PUNCT
fnp-4366	161	4	university	university	NOUN
fnp-4366	161	5	hospital	hospital	NOUN
fnp-4366	161	6	mannheim	mannheim	PROPN
fnp-4366	161	7	,	,	PUNCT
fnp-4366	161	8	mannheim	mannheim	PROPN
fnp-4366	161	9	,	,	PUNCT
fnp-4366	161	10	deutschland	deutschland	NOUN
fnp-4366	161	11	4	4	NUM
fnp-4366	161	12	dept	dept	NOUN
fnp-4366	161	13	.	.	PUNCT
fnp-4366	162	1	of	of	ADP
fnp-4366	162	2	neurosurgery	neurosurgery	NOUN
fnp-4366	162	3	,	,	PUNCT
fnp-4366	162	4	university	university	NOUN
fnp-4366	162	5	hospital	hospital	NOUN
fnp-4366	162	6	saarland	saarland	PROPN
fnp-4366	162	7	,	,	PUNCT
fnp-4366	162	8	homburg	homburg	PROPN
fnp-4366	162	9	,	,	PUNCT
fnp-4366	162	10	deutschland	deutschland	NOUN
fnp-4366	162	11	5	5	NUM
fnp-4366	162	12	dept	dept	NOUN
fnp-4366	162	13	.	.	PROPN
fnp-4366	163	1	of	of	ADP
fnp-4366	163	2	neurology	neurology	NOUN
fnp-4366	163	3	and	and	CCONJ
fnp-4366	163	4	neurooncology	neurooncology	NOUN
fnp-4366	163	5	program	program	NOUN
fnp-4366	163	6	,	,	PUNCT
fnp-4366	163	7	national	national	ADJ
fnp-4366	163	8	center	center	NOUN
fnp-4366	163	9	for	for	ADP
fnp-4366	163	10	tumor	tumor	NOUN
fnp-4366	163	11	diseases	disease	NOUN
fnp-4366	163	12	,	,	PUNCT
fnp-4366	163	13	university	university	NOUN
fnp-4366	163	14	hospital	hospital	NOUN
fnp-4366	163	15	heidelberg	heidelberg	PROPN
fnp-4366	163	16	,	,	PUNCT
fnp-4366	163	17	heidelberg	heidelberg	PROPN
fnp-4366	163	18	,	,	PUNCT
fnp-4366	163	19	deutschland	deutschland	NOUN
fnp-4366	163	20	background	background	NOUN
fnp-4366	163	21	:	:	PUNCT
fnp-4366	163	22	most	most	ADJ
fnp-4366	163	23	meningiomas	meningioma	NOUN
fnp-4366	163	24	carry	carry	VERB
fnp-4366	163	25	mutations	mutation	NOUN
fnp-4366	163	26	in	in	ADP
fnp-4366	163	27	the	the	DET
fnp-4366	163	28	tumor	tumor	NOUN
fnp-4366	163	29	suppressor	suppressor	NOUN
fnp-4366	163	30	neurofibromatosis	neurofibromatosis	NOUN
fnp-4366	163	31	gene	gene	NOUN
fnp-4366	163	32	2	2	NUM
fnp-4366	163	33	(	(	PUNCT
fnp-4366	163	34	nf2	nf2	ADJ
fnp-4366	163	35	)	)	PUNCT
fnp-4366	163	36	on	on	ADP
fnp-4366	163	37	chromosome	chromosome	NOUN
fnp-4366	163	38	22q	22q	NOUN
fnp-4366	163	39	,	,	PUNCT
fnp-4366	163	40	while	while	SCONJ
fnp-4366	163	41	nf2	nf2	VERB
fnp-4366	163	42	-	-	PUNCT
fnp-4366	163	43	wildtype	wildtype	NOUN
fnp-4366	163	44	meningiomas	meningioma	NOUN
fnp-4366	163	45	account	account	VERB
fnp-4366	163	46	for	for	ADP
fnp-4366	163	47	about	about	ADV
fnp-4366	163	48	one	one	NUM
fnp-4366	163	49	third	third	NOUN
fnp-4366	163	50	of	of	ADP
fnp-4366	163	51	all	all	PRON
fnp-4366	163	52	.	.	PUNCT
fnp-4366	164	1	in	in	ADP
fnp-4366	164	2	non	non	ADJ
fnp-4366	164	3	-	-	ADJ
fnp-4366	164	4	nf2	nf2	VERB
fnp-4366	164	5	-	-	PUNCT
fnp-4366	164	6	mutated	mutate	VERB
fnp-4366	164	7	cases	case	NOUN
fnp-4366	164	8	,	,	PUNCT
fnp-4366	164	9	smo	smo	PROPN
fnp-4366	164	10	,	,	PUNCT
fnp-4366	164	11	polr2a	polr2a	NOUN
fnp-4366	164	12	,	,	PUNCT
fnp-4366	164	13	pik3ca	pik3ca	PROPN
fnp-4366	164	14	,	,	PUNCT
fnp-4366	164	15	akt1	akt1	NOUN
fnp-4366	164	16	and	and	CCONJ
fnp-4366	164	17	klf4	klf4	PROPN
fnp-4366	164	18	mutations	mutation	NOUN
fnp-4366	164	19	,	,	PUNCT
fnp-4366	164	20	the	the	DET
fnp-4366	164	21	latter	latter	ADJ
fnp-4366	164	22	both	both	PRON
fnp-4366	164	23	typically	typically	ADV
fnp-4366	164	24	with	with	ADP
fnp-4366	164	25	traf7	traf7	NOUN
fnp-4366	164	26	mutations	mutation	NOUN
fnp-4366	164	27	,	,	PUNCT
fnp-4366	164	28	have	have	AUX
fnp-4366	164	29	been	be	AUX
fnp-4366	164	30	described	describe	VERB
fnp-4366	164	31	.	.	PUNCT
fnp-4366	165	1	the	the	DET
fnp-4366	165	2	combination	combination	NOUN
fnp-4366	165	3	of	of	ADP
fnp-4366	165	4	akt1	akt1	NOUN
fnp-4366	165	5	and	and	CCONJ
fnp-4366	165	6	klf4	klf4	PROPN
fnp-4366	165	7	,	,	PUNCT
fnp-4366	165	8	respectively	respectively	ADV
fnp-4366	165	9	,	,	PUNCT
fnp-4366	165	10	with	with	ADP
fnp-4366	165	11	traf7	traf7	NOUN
fnp-4366	165	12	is	be	AUX
fnp-4366	165	13	intriguing	intriguing	ADJ
fnp-4366	165	14	:	:	PUNCT
fnp-4366	165	15	traf7	traf7	ADJ
fnp-4366	165	16	/	/	SYM
fnp-4366	165	17	akt1	akt1	PROPN
fnp-4366	165	18	co	co	NOUN
fnp-4366	165	19	-	-	NOUN
fnp-4366	165	20	mutations	mutation	NOUN
fnp-4366	165	21	are	be	AUX
fnp-4366	165	22	associated	associate	VERB
fnp-4366	165	23	with	with	ADP
fnp-4366	165	24	meningothelial	meningothelial	ADJ
fnp-4366	165	25	histology	histology	NOUN
fnp-4366	165	26	and	and	CCONJ
fnp-4366	165	27	basal	basal	PROPN
fnp-4366	165	28	localization	localization	NOUN
fnp-4366	165	29	,	,	PUNCT
fnp-4366	165	30	while	while	SCONJ
fnp-4366	165	31	traf7	traf7	PROPN
fnp-4366	165	32	/	/	SYM
fnp-4366	165	33	klf4	klf4	NOUN
fnp-4366	165	34	co	co	NOUN
fnp-4366	165	35	-	-	NOUN
fnp-4366	165	36	mutations	mutation	NOUN
fnp-4366	165	37	are	be	AUX
fnp-4366	165	38	highly	highly	ADV
fnp-4366	165	39	specific	specific	ADJ
fnp-4366	165	40	for	for	ADP
fnp-4366	165	41	secretory	secretory	ADJ
fnp-4366	165	42	meningioma	meningioma	NOUN
fnp-4366	165	43	without	without	ADP
fnp-4366	165	44	any	any	DET
fnp-4366	165	45	predominant	predominant	ADJ
fnp-4366	165	46	localization	localization	NOUN
fnp-4366	165	47	.	.	PUNCT
fnp-4366	166	1	since	since	SCONJ
fnp-4366	166	2	bulk	bulk	ADJ
fnp-4366	166	3	molecular	molecular	ADJ
fnp-4366	166	4	profiling	profiling	NOUN
fnp-4366	166	5	indicates	indicate	VERB
fnp-4366	166	6	a	a	DET
fnp-4366	166	7	step	step	NOUN
fnp-4366	166	8	-	-	PUNCT
fnp-4366	166	9	wise	wise	ADJ
fnp-4366	166	10	mutational	mutational	ADJ
fnp-4366	166	11	acquisition	acquisition	NOUN
fnp-4366	166	12	,	,	PUNCT
fnp-4366	166	13	the	the	DET
fnp-4366	166	14	mutational	mutational	ADJ
fnp-4366	166	15	sequence	sequence	NOUN
fnp-4366	166	16	,	,	PUNCT
fnp-4366	166	17	whether	whether	SCONJ
fnp-4366	166	18	the	the	DET
fnp-4366	166	19	alteration	alteration	NOUN
fnp-4366	166	20	in	in	ADP
fnp-4366	166	21	traf7	traf7	PROPN
fnp-4366	166	22	or	or	CCONJ
fnp-4366	166	23	in	in	ADP
fnp-4366	166	24	akt1	akt1	PROPN
fnp-4366	166	25	/	/	SYM
fnp-4366	166	26	klf4	klf4	PROPN
fnp-4366	166	27	occurs	occur	VERB
fnp-4366	166	28	first	first	ADV
fnp-4366	166	29	,	,	PUNCT
fnp-4366	166	30	has	have	AUX
fnp-4366	166	31	remained	remain	VERB
fnp-4366	166	32	elusive	elusive	ADJ
fnp-4366	166	33	.	.	PUNCT
fnp-4366	167	1	methods	method	NOUN
fnp-4366	167	2	:	:	PUNCT
fnp-4366	167	3	single	single	ADJ
fnp-4366	167	4	-	-	PUNCT
fnp-4366	167	5	cell	cell	NOUN
fnp-4366	167	6	sequencing	sequence	VERB
fnp-4366	167	7	technologies	technology	NOUN
fnp-4366	167	8	have	have	AUX
fnp-4366	167	9	allowed	allow	VERB
fnp-4366	167	10	direct	direct	ADJ
fnp-4366	167	11	insight	insight	NOUN
fnp-4366	167	12	into	into	ADP
fnp-4366	167	13	the	the	DET
fnp-4366	167	14	clonal	clonal	ADJ
fnp-4366	167	15	architecture	architecture	NOUN
fnp-4366	167	16	and	and	CCONJ
fnp-4366	167	17	complexity	complexity	NOUN
fnp-4366	167	18	of	of	ADP
fnp-4366	167	19	thousands	thousand	NOUN
fnp-4366	167	20	of	of	ADP
fnp-4366	167	21	individual	individual	ADJ
fnp-4366	167	22	cells	cell	NOUN
fnp-4366	167	23	.	.	PUNCT
fnp-4366	168	1	after	after	SCONJ
fnp-4366	168	2	evaluation	evaluation	NOUN
fnp-4366	168	3	of	of	ADP
fnp-4366	168	4	a	a	DET
fnp-4366	168	5	patient	patient	NOUN
fnp-4366	168	6	with	with	ADP
fnp-4366	168	7	two	two	NUM
fnp-4366	168	8	independent	independent	ADJ
fnp-4366	168	9	meningiomas	meningioma	NOUN
fnp-4366	168	10	having	have	VERB
fnp-4366	168	11	identical	identical	ADJ
fnp-4366	168	12	somatic	somatic	ADJ
fnp-4366	168	13	traf7	traf7	NOUN
fnp-4366	168	14	mutation	mutation	NOUN
fnp-4366	168	15	but	but	CCONJ
fnp-4366	168	16	separate	separate	ADJ
fnp-4366	168	17	akt1	akt1	PROPN
fnp-4366	168	18	/	/	SYM
fnp-4366	168	19	klf4	klf4	PROPN
fnp-4366	168	20	hotspot	hotspot	NOUN
fnp-4366	168	21	mutation	mutation	NOUN
fnp-4366	168	22	,	,	PUNCT
fnp-4366	168	23	variant	variant	ADJ
fnp-4366	168	24	allele	allele	NOUN
fnp-4366	168	25	frequencies	frequency	NOUN
fnp-4366	168	26	(	(	PUNCT
fnp-4366	168	27	vafs	vafs	NOUN
fnp-4366	168	28	)	)	PUNCT
fnp-4366	168	29	of	of	ADP
fnp-4366	168	30	62	62	NUM
fnp-4366	168	31	retrospectively	retrospectively	ADV
fnp-4366	168	32	collected	collect	VERB
fnp-4366	168	33	meningiomas	meningioma	NOUN
fnp-4366	168	34	carrying	carry	VERB
fnp-4366	168	35	either	either	CCONJ
fnp-4366	168	36	coor	coor	ADJ
fnp-4366	168	37	single	single	ADJ
fnp-4366	168	38	-	-	PUNCT
fnp-4366	168	39	mutations	mutation	NOUN
fnp-4366	168	40	in	in	ADP
fnp-4366	168	41	traf7	traf7	NOUN
fnp-4366	168	42	and/or	and/or	CCONJ
fnp-4366	168	43	akt1	akt1	PROPN
fnp-4366	168	44	or	or	CCONJ
fnp-4366	168	45	klf4	klf4	NOUN
fnp-4366	168	46	were	be	AUX
fnp-4366	168	47	compared	compare	VERB
fnp-4366	168	48	using	use	VERB
fnp-4366	168	49	bulk	bulk	ADJ
fnp-4366	168	50	hybrid	hybrid	NOUN
fnp-4366	168	51	-	-	PUNCT
fnp-4366	168	52	capture	capture	NOUN
fnp-4366	168	53	panel	panel	NOUN
fnp-4366	168	54	sequencing	sequence	VERB
fnp-4366	168	55	data	datum	NOUN
fnp-4366	168	56	.	.	PUNCT
fnp-4366	169	1	additionally	additionally	ADV
fnp-4366	169	2	,	,	PUNCT
fnp-4366	169	3	a	a	DET
fnp-4366	169	4	custom	custom	NOUN
fnp-4366	169	5	tumor	tumor	NOUN
fnp-4366	169	6	panel	panel	NOUN
fnp-4366	169	7	comprising	comprise	VERB
fnp-4366	169	8	392	392	NUM
fnp-4366	169	9	amplicons	amplicon	NOUN
fnp-4366	169	10	covering	cover	VERB
fnp-4366	169	11	28	28	NUM
fnp-4366	169	12	genes	gene	NOUN
fnp-4366	169	13	as	as	ADV
fnp-4366	169	14	well	well	ADV
fnp-4366	169	15	as	as	ADP
fnp-4366	169	16	the	the	DET
fnp-4366	169	17	tert	tert	NOUN
fnp-4366	169	18	promoter	promoter	NOUN
fnp-4366	169	19	was	be	AUX
fnp-4366	169	20	used	use	VERB
fnp-4366	169	21	along	along	ADP
fnp-4366	169	22	with	with	ADP
fnp-4366	169	23	the	the	DET
fnp-4366	169	24	amplicon	amplicon	NOUN
fnp-4366	169	25	-	-	PUNCT
fnp-4366	169	26	based	base	VERB
fnp-4366	169	27	tapestri	tapestri	ADJ
fnp-4366	169	28	technology	technology	NOUN
fnp-4366	169	29	for	for	ADP
fnp-4366	169	30	single	single	ADJ
fnp-4366	169	31	cell	cell	NOUN
fnp-4366	169	32	dna	dna	NOUN
fnp-4366	169	33	sequencing	sequence	VERB
fnp-4366	169	34	.	.	PUNCT
fnp-4366	170	1	genotype	genotype	NOUN
fnp-4366	170	2	clustering	clustering	NOUN
fnp-4366	170	3	analysis	analysis	NOUN
fnp-4366	170	4	was	be	AUX
fnp-4366	170	5	finally	finally	ADV
fnp-4366	170	6	performed	perform	VERB
fnp-4366	170	7	to	to	PART
fnp-4366	170	8	reveal	reveal	VERB
fnp-4366	170	9	the	the	DET
fnp-4366	170	10	order	order	NOUN
fnp-4366	170	11	of	of	ADP
fnp-4366	170	12	mutational	mutational	ADJ
fnp-4366	170	13	acquisition	acquisition	NOUN
fnp-4366	170	14	in	in	ADP
fnp-4366	170	15	our	our	PRON
fnp-4366	170	16	cohort	cohort	NOUN
fnp-4366	170	17	of	of	ADP
fnp-4366	170	18	traf7mut	traf7mut	NOUN
fnp-4366	170	19	/	/	SYM
fnp-4366	170	20	akt1mut	akt1mut	NOUN
fnp-4366	170	21	and	and	CCONJ
fnp-4366	170	22	traf7mut	traf7mut	NOUN
fnp-4366	170	23	/	/	SYM
fnp-4366	170	24	klf4mut	klf4mut	NOUN
fnp-4366	170	25	meningiomas	meningioma	NOUN
fnp-4366	170	26	(	(	PUNCT
fnp-4366	170	27	n=7	n=7	PROPN
fnp-4366	170	28	)	)	PUNCT
fnp-4366	170	29	.	.	PUNCT
fnp-4366	171	1	results	result	NOUN
fnp-4366	171	2	:	:	PUNCT
fnp-4366	171	3	looking	look	VERB
fnp-4366	171	4	at	at	ADP
fnp-4366	171	5	mutational	mutational	ADJ
fnp-4366	171	6	co	co	NOUN
fnp-4366	171	7	-	-	NOUN
fnp-4366	171	8	occurrence	occurrence	NOUN
fnp-4366	171	9	in	in	ADP
fnp-4366	171	10	bulk	bulk	ADJ
fnp-4366	171	11	data	datum	NOUN
fnp-4366	171	12	,	,	PUNCT
fnp-4366	171	13	mutations	mutation	NOUN
fnp-4366	171	14	assigned	assign	VERB
fnp-4366	171	15	with	with	ADP
fnp-4366	171	16	higher	high	ADJ
fnp-4366	171	17	vafs	vafs	NOUN
fnp-4366	171	18	,	,	PUNCT
fnp-4366	171	19	unless	unless	SCONJ
fnp-4366	171	20	explained	explain	VERB
fnp-4366	171	21	by	by	ADP
fnp-4366	171	22	copy	copy	NOUN
fnp-4366	171	23	number	number	NOUN
fnp-4366	171	24	changes	change	NOUN
fnp-4366	171	25	,	,	PUNCT
fnp-4366	171	26	are	be	AUX
fnp-4366	171	27	thought	think	VERB
fnp-4366	171	28	to	to	PART
fnp-4366	171	29	be	be	AUX
fnp-4366	171	30	acquired	acquire	VERB
fnp-4366	171	31	earlier	early	ADV
fnp-4366	171	32	than	than	ADP
fnp-4366	171	33	those	those	PRON
fnp-4366	171	34	with	with	ADP
fnp-4366	171	35	lower	low	ADJ
fnp-4366	171	36	vafs	vafs	NOUN
fnp-4366	171	37	.	.	PUNCT
fnp-4366	172	1	our	our	PRON
fnp-4366	172	2	bulk	bulk	ADJ
fnp-4366	172	3	data	datum	NOUN
fnp-4366	172	4	of	of	ADP
fnp-4366	172	5	28	28	NUM
fnp-4366	172	6	co	co	ADJ
fnp-4366	172	7	-	-	ADJ
fnp-4366	172	8	mutated	mutate	VERB
fnp-4366	172	9	cases	case	NOUN
fnp-4366	172	10	showed	show	VERB
fnp-4366	172	11	no	no	DET
fnp-4366	172	12	significant	significant	ADJ
fnp-4366	172	13	difference	difference	NOUN
fnp-4366	172	14	in	in	ADP
fnp-4366	172	15	bulk	bulk	NOUN
fnp-4366	172	16	-	-	PUNCT
fnp-4366	172	17	measured	measure	VERB
fnp-4366	172	18	vafs	vafs	NOUN
fnp-4366	172	19	,	,	PUNCT
fnp-4366	172	20	suggesting	suggest	VERB
fnp-4366	172	21	there	there	PRON
fnp-4366	172	22	was	be	VERB
fnp-4366	172	23	no	no	DET
fnp-4366	172	24	major	major	ADJ
fnp-4366	172	25	gap	gap	NOUN
fnp-4366	172	26	between	between	ADP
fnp-4366	172	27	the	the	DET
fnp-4366	172	28	two	two	NUM
fnp-4366	172	29	time	time	NOUN
fnp-4366	172	30	points	point	NOUN
fnp-4366	172	31	of	of	ADP
fnp-4366	172	32	mutational	mutational	ADJ
fnp-4366	172	33	acquisition	acquisition	NOUN
fnp-4366	172	34	.	.	PUNCT
fnp-4366	173	1	however	however	ADV
fnp-4366	173	2	,	,	PUNCT
fnp-4366	173	3	the	the	DET
fnp-4366	173	4	majority	majority	NOUN
fnp-4366	173	5	of	of	ADP
fnp-4366	173	6	single	single	ADJ
fnp-4366	173	7	-	-	PUNCT
fnp-4366	173	8	mutated	mutate	VERB
fnp-4366	173	9	cases	case	NOUN
fnp-4366	173	10	(	(	PUNCT
fnp-4366	173	11	21/36	21/36	NUM
fnp-4366	173	12	)	)	PUNCT
fnp-4366	173	13	harbored	harbor	VERB
fnp-4366	173	14	mutations	mutation	NOUN
fnp-4366	173	15	in	in	ADP
fnp-4366	173	16	traf7	traf7	PROPN
fnp-4366	173	17	,	,	PUNCT
fnp-4366	173	18	while	while	SCONJ
fnp-4366	173	19	the	the	DET
fnp-4366	173	20	others	other	NOUN
fnp-4366	173	21	were	be	AUX
fnp-4366	173	22	either	either	CCONJ
fnp-4366	173	23	only	only	ADV
fnp-4366	173	24	akt1	akt1	NOUN
fnp-4366	173	25	(	(	PUNCT
fnp-4366	173	26	n=12	n=12	NOUN
fnp-4366	173	27	)	)	PUNCT
fnp-4366	173	28	or	or	CCONJ
fnp-4366	173	29	klf4	klf4	NOUN
fnp-4366	173	30	(	(	PUNCT
fnp-4366	173	31	n=3	n=3	NOUN
fnp-4366	173	32	)	)	PUNCT
fnp-4366	173	33	mutant	mutant	NOUN
fnp-4366	173	34	.	.	PUNCT
fnp-4366	174	1	while	while	SCONJ
fnp-4366	174	2	it	it	PRON
fnp-4366	174	3	remains	remain	VERB
fnp-4366	174	4	impossible	impossible	ADJ
fnp-4366	174	5	to	to	PART
fnp-4366	174	6	delineate	delineate	VERB
fnp-4366	174	7	clonal	clonal	ADJ
fnp-4366	174	8	architecture	architecture	NOUN
fnp-4366	174	9	from	from	ADP
fnp-4366	174	10	bulk	bulk	ADJ
fnp-4366	174	11	data	datum	NOUN
fnp-4366	174	12	,	,	PUNCT
fnp-4366	174	13	our	our	PRON
fnp-4366	174	14	single	single	ADJ
fnp-4366	174	15	cell	cell	NOUN
fnp-4366	174	16	data	datum	NOUN
fnp-4366	174	17	allowed	allow	VERB
fnp-4366	174	18	grouping	grouping	NOUN
fnp-4366	174	19	of	of	ADP
fnp-4366	174	20	cells	cell	NOUN
fnp-4366	174	21	into	into	ADP
fnp-4366	174	22	clonal	clonal	ADJ
fnp-4366	174	23	populations	population	NOUN
fnp-4366	174	24	.	.	PUNCT
fnp-4366	175	1	a	a	DET
fnp-4366	175	2	total	total	NOUN
fnp-4366	175	3	of	of	ADP
fnp-4366	175	4	875,000	875,000	NUM
fnp-4366	175	5	cells	cell	NOUN
fnp-4366	175	6	from	from	ADP
fnp-4366	175	7	7	7	NUM
fnp-4366	175	8	samples	sample	NOUN
fnp-4366	175	9	were	be	AUX
fnp-4366	175	10	prepared	prepare	VERB
fnp-4366	175	11	resulting	result	VERB
fnp-4366	175	12	in	in	ADP
fnp-4366	175	13	a	a	DET
fnp-4366	175	14	median	median	ADJ
fnp-4366	175	15	throughput	throughput	NOUN
fnp-4366	175	16	of	of	ADP
fnp-4366	175	17	2315	2315	NUM
fnp-4366	175	18	cells	cell	NOUN
fnp-4366	175	19	per	per	ADP
fnp-4366	175	20	sample	sample	NOUN
fnp-4366	175	21	and	and	CCONJ
fnp-4366	175	22	a	a	DET
fnp-4366	175	23	median	median	ADJ
fnp-4366	175	24	sequencing	sequence	VERB
fnp-4366	175	25	coverage	coverage	NOUN
fnp-4366	175	26	of	of	ADP
fnp-4366	175	27	105	105	NUM
fnp-4366	175	28	reads	read	NOUN
fnp-4366	175	29	per	per	ADP
fnp-4366	175	30	cell	cell	NOUN
fnp-4366	175	31	per	per	ADP
fnp-4366	175	32	amplicon	amplicon	NOUN
fnp-4366	175	33	.	.	PUNCT
fnp-4366	176	1	our	our	PRON
fnp-4366	176	2	data	datum	NOUN
fnp-4366	176	3	revealed	reveal	VERB
fnp-4366	176	4	three	three	NUM
fnp-4366	176	5	subclones	subclone	NOUN
fnp-4366	176	6	in	in	ADP
fnp-4366	176	7	each	each	DET
fnp-4366	176	8	sample	sample	NOUN
fnp-4366	176	9	:	:	PUNCT
fnp-4366	176	10	one	one	NUM
fnp-4366	176	11	wildtype	wildtype	NOUN
fnp-4366	176	12	clone	clone	NOUN
fnp-4366	176	13	(	(	PUNCT
fnp-4366	176	14	potentially	potentially	ADV
fnp-4366	176	15	stroma	stroma	ADJ
fnp-4366	176	16	cells	cell	NOUN
fnp-4366	176	17	)	)	PUNCT
fnp-4366	176	18	,	,	PUNCT
fnp-4366	176	19	one	one	NUM
fnp-4366	176	20	clone	clone	NOUN
fnp-4366	176	21	carrying	carry	VERB
fnp-4366	176	22	a	a	DET
fnp-4366	176	23	single	single	ADJ
fnp-4366	176	24	mutation	mutation	NOUN
fnp-4366	176	25	in	in	ADP
fnp-4366	176	26	traf7	traf7	PROPN
fnp-4366	176	27	(	(	PUNCT
fnp-4366	176	28	detected	detect	VERB
fnp-4366	176	29	for	for	ADP
fnp-4366	176	30	6/7	6/7	NUM
fnp-4366	176	31	samples	sample	NOUN
fnp-4366	176	32	)	)	PUNCT
fnp-4366	176	33	and	and	CCONJ
fnp-4366	176	34	another	another	DET
fnp-4366	176	35	clone	clone	NOUN
fnp-4366	176	36	harboring	harbor	VERB
fnp-4366	176	37	the	the	DET
fnp-4366	176	38	co	co	NOUN
fnp-4366	176	39	-	-	NOUN
fnp-4366	176	40	mutations	mutation	NOUN
fnp-4366	176	41	in	in	ADP
fnp-4366	176	42	traf7	traf7	PROPN
fnp-4366	176	43	and	and	CCONJ
fnp-4366	176	44	klf4	klf4	PROPN
fnp-4366	176	45	or	or	CCONJ
fnp-4366	176	46	akt1	akt1	PROPN
fnp-4366	176	47	.	.	PUNCT
fnp-4366	177	1	conclusions	conclusion	NOUN
fnp-4366	177	2	:	:	PUNCT
fnp-4366	177	3	our	our	PRON
fnp-4366	177	4	findings	finding	NOUN
fnp-4366	177	5	strengthen	strengthen	VERB
fnp-4366	177	6	the	the	DET
fnp-4366	177	7	hypothesis	hypothesis	NOUN
fnp-4366	177	8	that	that	SCONJ
fnp-4366	177	9	in	in	ADP
fnp-4366	177	10	traf7mut	traf7mut	NOUN
fnp-4366	177	11	/	/	SYM
fnp-4366	177	12	akt1mut	akt1mut	NOUN
fnp-4366	177	13	and	and	CCONJ
fnp-4366	177	14	traf7mut	traf7mut	NOUN
fnp-4366	177	15	/	/	SYM
fnp-4366	177	16	klf4mut	klf4mut	NOUN
fnp-4366	177	17	meningiomas	meningioma	NOUN
fnp-4366	177	18	,	,	PUNCT
fnp-4366	177	19	the	the	DET
fnp-4366	177	20	mutation	mutation	NOUN
fnp-4366	177	21	in	in	ADP
fnp-4366	177	22	traf7	traf7	PROPN
fnp-4366	177	23	,	,	PUNCT
fnp-4366	177	24	which	which	PRON
fnp-4366	177	25	can	can	AUX
fnp-4366	177	26	occur	occur	VERB
fnp-4366	177	27	throughout	throughout	ADP
fnp-4366	177	28	the	the	DET
fnp-4366	177	29	wd40	wd40	PROPN
fnp-4366	177	30	domain	domain	NOUN
fnp-4366	177	31	of	of	ADP
fnp-4366	177	32	the	the	DET
fnp-4366	177	33	protein	protein	NOUN
fnp-4366	177	34	,	,	PUNCT
fnp-4366	177	35	is	be	AUX
fnp-4366	177	36	acquired	acquire	VERB
fnp-4366	177	37	in	in	ADP
fnp-4366	177	38	an	an	DET
fnp-4366	177	39	earlier	early	ADJ
fnp-4366	177	40	stage	stage	NOUN
fnp-4366	177	41	than	than	ADP
fnp-4366	177	42	the	the	DET
fnp-4366	177	43	hotspot	hotspot	NOUN
fnp-4366	177	44	mutation	mutation	NOUN
fnp-4366	177	45	in	in	ADP
fnp-4366	177	46	akt1	akt1	PROPN
fnp-4366	177	47	or	or	CCONJ
fnp-4366	177	48	klf4	klf4	PROPN
fnp-4366	177	49	.	.	PUNCT
fnp-4366	178	1	this	this	DET
fnp-4366	178	2	study	study	NOUN
fnp-4366	178	3	shows	show	VERB
fnp-4366	178	4	,	,	PUNCT
fnp-4366	178	5	that	that	SCONJ
fnp-4366	178	6	single	single	ADJ
fnp-4366	178	7	-	-	PUNCT
fnp-4366	178	8	cell	cell	NOUN
fnp-4366	178	9	technologies	technology	NOUN
fnp-4366	178	10	on	on	ADP
fnp-4366	178	11	dna	dna	PROPN
fnp-4366	178	12	are	be	AUX
fnp-4366	178	13	useful	useful	ADJ
fnp-4366	178	14	in	in	ADP
fnp-4366	178	15	elucidating	elucidate	VERB
fnp-4366	178	16	clonal	clonal	ADJ
fnp-4366	178	17	architecture	architecture	NOUN
fnp-4366	178	18	and	and	CCONJ
fnp-4366	178	19	phylogenetic	phylogenetic	ADJ
fnp-4366	178	20	trees	tree	NOUN
fnp-4366	178	21	.	.	PUNCT
fnp-4366	179	1	although	although	SCONJ
fnp-4366	179	2	single	single	ADJ
fnp-4366	179	3	-	-	PUNCT
fnp-4366	179	4	cell	cell	NOUN
fnp-4366	179	5	dna	dna	NOUN
fnp-4366	179	6	sequencing	sequence	VERB
fnp-4366	179	7	in	in	ADP
fnp-4366	179	8	particular	particular	ADJ
fnp-4366	179	9	is	be	AUX
fnp-4366	179	10	associated	associate	VERB
fnp-4366	179	11	with	with	ADP
fnp-4366	179	12	technical	technical	ADJ
fnp-4366	179	13	challenges	challenge	NOUN
fnp-4366	179	14	such	such	ADJ
fnp-4366	179	15	as	as	ADP
fnp-4366	179	16	false	false	ADJ
fnp-4366	179	17	positive	positive	ADJ
fnp-4366	179	18	variant	variant	NOUN
fnp-4366	179	19	calling	calling	NOUN
fnp-4366	179	20	and	and	CCONJ
fnp-4366	179	21	allelic	allelic	ADJ
fnp-4366	179	22	dropouts	dropout	NOUN
fnp-4366	179	23	,	,	PUNCT
fnp-4366	179	24	high	high	ADJ
fnp-4366	179	25	numbers	number	NOUN
fnp-4366	179	26	of	of	ADP
fnp-4366	179	27	recovered	recovered	ADJ
fnp-4366	179	28	cells	cell	NOUN
fnp-4366	179	29	as	as	ADV
fnp-4366	179	30	well	well	ADV
fnp-4366	179	31	as	as	ADP
fnp-4366	179	32	high	high	ADJ
fnp-4366	179	33	-	-	PUNCT
fnp-4366	179	34	quality	quality	NOUN
fnp-4366	179	35	sequencing	sequencing	NOUN
fnp-4366	179	36	allow	allow	VERB
fnp-4366	179	37	conclusive	conclusive	ADJ
fnp-4366	179	38	information	information	NOUN
fnp-4366	179	39	on	on	ADP
fnp-4366	179	40	cellular	cellular	ADJ
fnp-4366	179	41	zygosity	zygosity	NOUN
fnp-4366	179	42	and	and	CCONJ
fnp-4366	179	43	a	a	DET
fnp-4366	179	44	robust	robust	ADJ
fnp-4366	179	45	analysis	analysis	NOUN
fnp-4366	179	46	of	of	ADP
fnp-4366	179	47	mutational	mutational	ADJ
fnp-4366	179	48	acquisition	acquisition	NOUN
fnp-4366	179	49	.	.	PUNCT
fnp-4366	179	50	  	  	SPACE
fnp-4366	180	1	2.03	2.03	NUM
fnp-4366	180	2	free	free	ADJ
fnp-4366	180	3	neuropathol	neuropathol	NOUN
fnp-4366	180	4	3:20:20	3:20:20	NUM
fnp-4366	180	5	alterations	alteration	NOUN
fnp-4366	180	6	in	in	ADP
fnp-4366	180	7	ptpn11	ptpn11	NOUN
fnp-4366	180	8	and	and	CCONJ
fnp-4366	180	9	other	other	ADJ
fnp-4366	180	10	noonan	noonan	PROPN
fnp-4366	180	11	syndrome	syndrome	PROPN
fnp-4366	180	12	associated	associate	VERB
fnp-4366	180	13	map	map	PROPN
fnp-4366	180	14	-	-	PUNCT
fnp-4366	180	15	kinase	kinase	NOUN
fnp-4366	180	16	signaling	signal	VERB
fnp-4366	180	17	pathway	pathway	NOUN
fnp-4366	180	18	genes	gene	NOUN
fnp-4366	180	19	accumulate	accumulate	VERB
fnp-4366	180	20	in	in	ADP
fnp-4366	180	21	histopathologically	histopathologically	ADV
fnp-4366	180	22	atypical	atypical	ADJ
fnp-4366	180	23	ganglioglioma	ganglioglioma	NOUN
fnp-4366	180	24	with	with	ADP
fnp-4366	180	25	adverse	adverse	ADJ
fnp-4366	180	26	postsurgical	postsurgical	ADJ
fnp-4366	180	27	outcome	outcome	NOUN
fnp-4366	180	28	lucas	lucas	PROPN
fnp-4366	180	29	hoffmann1	hoffmann1	PROPN
fnp-4366	180	30	,	,	PUNCT
fnp-4366	180	31	roland	roland	PROPN
fnp-4366	180	32	coras1	coras1	PROPN
fnp-4366	180	33	,	,	PUNCT
fnp-4366	180	34	katja	katja	PROPN
fnp-4366	180	35	kobow1	kobow1	PROPN
fnp-4366	180	36	,	,	PUNCT
fnp-4366	180	37	javier	javier	PROPN
fnp-4366	180	38	lopez	lopez	PROPN
fnp-4366	180	39	-	-	PUNCT
fnp-4366	180	40	riviera2,3,4	riviera2,3,4	NOUN
fnp-4366	180	41	,	,	PUNCT
fnp-4366	180	42	costin	costin	PROPN
fnp-4366	180	43	leu3,4,5,6	leu3,4,5,6	PROPN
fnp-4366	180	44	,	,	PUNCT
fnp-4366	180	45	dennis	dennis	PROPN
fnp-4366	180	46	lal3,4,5,6	lal3,4,5,6	PROPN
fnp-4366	180	47	,	,	PUNCT
fnp-4366	180	48	peter	peter	PROPN
fnp-4366	180	49	nürnberg6	nürnberg6	PROPN
fnp-4366	180	50	,	,	PUNCT
fnp-4366	180	51	christian	christian	PROPN
fnp-4366	180	52	g.	g.	PROPN
fnp-4366	180	53	bien7	bien7	PROPN
fnp-4366	180	54	,	,	PUNCT
fnp-4366	180	55	thilo	thilo	PROPN
fnp-4366	180	56	kalbhenn7	kalbhenn7	NOUN
fnp-4366	180	57	,	,	PUNCT
fnp-4366	180	58	markus	markus	PROPN
fnp-4366	180	59	müller7	müller7	PROPN
fnp-4366	180	60	,	,	PUNCT
fnp-4366	180	61	hajo	hajo	ADV
fnp-4366	180	62	hamer8	hamer8	PROPN
fnp-4366	180	63	,	,	PUNCT
fnp-4366	180	64	sebastian	sebastian	PROPN
fnp-4366	180	65	brandner9	brandner9	PROPN
fnp-4366	180	66	,	,	PUNCT
fnp-4366	180	67	karl	karl	PROPN
fnp-4366	180	68	rössler9,10	rössler9,10	PROPN
fnp-4366	180	69	,	,	PUNCT
fnp-4366	180	70	samir	samir	PROPN
fnp-4366	180	71	jabari1	jabari1	PROPN
fnp-4366	180	72	,	,	PUNCT
fnp-4366	180	73	ingmar	ingmar	PROPN
fnp-4366	180	74	blümcke1	blümcke1	PROPN
fnp-4366	180	75	1	1	NUM
fnp-4366	180	76	department	department	NOUN
fnp-4366	180	77	of	of	ADP
fnp-4366	180	78	neuropathology	neuropathology	NOUN
fnp-4366	180	79	,	,	PUNCT
fnp-4366	180	80	universitätsklinikum	universitätsklinikum	ADJ
fnp-4366	180	81	erlangen	erlangen	PROPN
fnp-4366	180	82	,	,	PUNCT
fnp-4366	180	83	fau	fau	PROPN
fnp-4366	180	84	erlangen	erlangen	PROPN
fnp-4366	180	85	-	-	PUNCT
fnp-4366	180	86	nürnberg	nürnberg	PROPN
fnp-4366	180	87	,	,	PUNCT
fnp-4366	180	88	partner	partner	NOUN
fnp-4366	180	89	of	of	ADP
fnp-4366	180	90	the	the	DET
fnp-4366	180	91	european	european	PROPN
fnp-4366	180	92	reference	reference	NOUN
fnp-4366	180	93	network	network	NOUN
fnp-4366	180	94	(	(	PUNCT
fnp-4366	180	95	ern	ern	PROPN
fnp-4366	180	96	)	)	PUNCT
fnp-4366	180	97	epicare	epicare	PROPN
fnp-4366	180	98	,	,	PUNCT
fnp-4366	180	99	erlangen	erlangen	PROPN
fnp-4366	180	100	,	,	PUNCT
fnp-4366	180	101	deutschland	deutschland	PROPN
fnp-4366	180	102	2	2	NUM
fnp-4366	180	103	department	department	NOUN
fnp-4366	180	104	of	of	ADP
fnp-4366	180	105	molecular	molecular	ADJ
fnp-4366	180	106	medicine	medicine	NOUN
fnp-4366	180	107	,	,	PUNCT
fnp-4366	180	108	cleveland	cleveland	PROPN
fnp-4366	180	109	clinic	clinic	PROPN
fnp-4366	180	110	lerner	lerner	PROPN
fnp-4366	180	111	college	college	PROPN
fnp-4366	180	112	of	of	ADP
fnp-4366	180	113	medicine	medicine	NOUN
fnp-4366	180	114	,	,	PUNCT
fnp-4366	180	115	case	case	NOUN
fnp-4366	180	116	western	western	PROPN
fnp-4366	180	117	reserve	reserve	PROPN
fnp-4366	180	118	university	university	PROPN
fnp-4366	180	119	,	,	PUNCT
fnp-4366	180	120	cleveland	cleveland	PROPN
fnp-4366	180	121	,	,	PUNCT
fnp-4366	180	122	united	united	PROPN
fnp-4366	180	123	states	states	PROPN
fnp-4366	180	124	3	3	NUM
fnp-4366	180	125	genomic	genomic	PROPN
fnp-4366	180	126	medicine	medicine	PROPN
fnp-4366	180	127	institute	institute	PROPN
fnp-4366	180	128	,	,	PUNCT
fnp-4366	180	129	lerner	lerner	PROPN
fnp-4366	180	130	research	research	PROPN
fnp-4366	180	131	institute	institute	PROPN
fnp-4366	180	132	,	,	PUNCT
fnp-4366	180	133	cleveland	cleveland	PROPN
fnp-4366	180	134	clinic	clinic	PROPN
fnp-4366	180	135	,	,	PUNCT
fnp-4366	180	136	cleveland	cleveland	PROPN
fnp-4366	180	137	,	,	PUNCT
fnp-4366	180	138	oh	oh	NUM
fnp-4366	180	139	44195	44195	NUM
fnp-4366	180	140	,	,	PUNCT
fnp-4366	180	141	united	united	PROPN
fnp-4366	180	142	states	states	PROPN
fnp-4366	180	143	4	4	NUM
fnp-4366	180	144	charles	charles	PROPN
fnp-4366	180	145	shor	shor	PROPN
fnp-4366	180	146	epilepsy	epilepsy	PROPN
fnp-4366	180	147	center	center	NOUN
fnp-4366	180	148	,	,	PUNCT
fnp-4366	180	149	neurological	neurological	ADJ
fnp-4366	180	150	institute	institute	NOUN
fnp-4366	180	151	,	,	PUNCT
fnp-4366	180	152	cleveland	cleveland	PROPN
fnp-4366	180	153	clinic	clinic	PROPN
fnp-4366	180	154	,	,	PUNCT
fnp-4366	180	155	cleveland	cleveland	PROPN
fnp-4366	180	156	,	,	PUNCT
fnp-4366	180	157	united	united	PROPN
fnp-4366	180	158	states	states	PROPN
fnp-4366	180	159	;	;	PUNCT
fnp-4366	180	160	5	5	NUM
fnp-4366	180	161	stanley	stanley	NOUN
fnp-4366	180	162	center	center	PROPN
fnp-4366	180	163	for	for	ADP
fnp-4366	180	164	psychiatric	psychiatric	ADJ
fnp-4366	180	165	research	research	NOUN
fnp-4366	180	166	,	,	PUNCT
fnp-4366	180	167	broad	broad	PROPN
fnp-4366	180	168	institute	institute	PROPN
fnp-4366	180	169	of	of	ADP
fnp-4366	180	170	harvard	harvard	PROPN
fnp-4366	180	171	and	and	CCONJ
fnp-4366	180	172	m.i.t	m.i.t	PROPN
fnp-4366	180	173	,	,	PUNCT
fnp-4366	180	174	cambridge	cambridge	PROPN
fnp-4366	180	175	,	,	PUNCT
fnp-4366	180	176	ma	ma	PROPN
fnp-4366	180	177	02142	02142	NUM
fnp-4366	180	178	,	,	PUNCT
fnp-4366	180	179	united	united	PROPN
fnp-4366	180	180	states	states	PROPN
fnp-4366	180	181	6	6	NUM
fnp-4366	180	182	cologne	cologne	NOUN
fnp-4366	180	183	center	center	NOUN
fnp-4366	180	184	for	for	ADP
fnp-4366	180	185	genomics	genomics	NOUN
fnp-4366	180	186	(	(	PUNCT
fnp-4366	180	187	ccg	ccg	NOUN
fnp-4366	180	188	)	)	PUNCT
fnp-4366	180	189	,	,	PUNCT
fnp-4366	180	190	medical	medical	ADJ
fnp-4366	180	191	faculty	faculty	NOUN
fnp-4366	180	192	of	of	ADP
fnp-4366	180	193	the	the	DET
fnp-4366	180	194	university	university	NOUN
fnp-4366	180	195	of	of	ADP
fnp-4366	180	196	cologne	cologne	NOUN
fnp-4366	180	197	,	,	PUNCT
fnp-4366	180	198	university	university	NOUN
fnp-4366	180	199	hospital	hospital	NOUN
fnp-4366	180	200	of	of	ADP
fnp-4366	180	201	cologne	cologne	NOUN
fnp-4366	180	202	,	,	PUNCT
fnp-4366	180	203	cologne	cologne	NOUN
fnp-4366	180	204	,	,	PUNCT
fnp-4366	180	205	germany	germany	PROPN
fnp-4366	180	206	7	7	NUM
fnp-4366	180	207	department	department	PROPN
fnp-4366	180	208	of	of	ADP
fnp-4366	180	209	epileptology	epileptology	NOUN
fnp-4366	180	210	(	(	PUNCT
fnp-4366	180	211	krankenhaus	krankenhaus	PROPN
fnp-4366	180	212	mara	mara	PROPN
fnp-4366	180	213	)	)	PUNCT
fnp-4366	180	214	,	,	PUNCT
fnp-4366	180	215	medical	medical	ADJ
fnp-4366	180	216	school	school	NOUN
fnp-4366	180	217	,	,	PUNCT
fnp-4366	180	218	bielefeld	bielefeld	PROPN
fnp-4366	180	219	university	university	PROPN
fnp-4366	180	220	,	,	PUNCT
fnp-4366	180	221	bielefeld	bielefeld	PROPN
fnp-4366	180	222	,	,	PUNCT
fnp-4366	180	223	germany	germany	PROPN
fnp-4366	180	224	8	8	NUM
fnp-4366	180	225	epilepsy	epilepsy	NOUN
fnp-4366	180	226	center	center	NOUN
fnp-4366	180	227	,	,	PUNCT
fnp-4366	180	228	universitätsklinikum	universitätsklinikum	ADJ
fnp-4366	180	229	erlangen	erlangen	PROPN
fnp-4366	180	230	,	,	PUNCT
fnp-4366	180	231	fau	fau	PROPN
fnp-4366	180	232	erlangen	erlangen	PROPN
fnp-4366	180	233	-	-	PUNCT
fnp-4366	180	234	nürnberg	nürnberg	PROPN
fnp-4366	180	235	,	,	PUNCT
fnp-4366	180	236	erlangen	erlangen	PROPN
fnp-4366	180	237	,	,	PUNCT
fnp-4366	180	238	germany	germany	PROPN
fnp-4366	180	239	,	,	PUNCT
fnp-4366	180	240	and	and	CCONJ
fnp-4366	180	241	epicare	epicare	PROPN
fnp-4366	180	242	partner	partner	PROPN
fnp-4366	180	243	,	,	PUNCT
fnp-4366	180	244	erlangen	erlangen	PROPN
fnp-4366	180	245	,	,	PUNCT
fnp-4366	180	246	germany	germany	PROPN
fnp-4366	180	247	9	9	NUM
fnp-4366	180	248	department	department	NOUN
fnp-4366	180	249	of	of	ADP
fnp-4366	180	250	neurosurgery	neurosurgery	NOUN
fnp-4366	180	251	,	,	PUNCT
fnp-4366	180	252	universitätsklinikum	universitätsklinikum	ADJ
fnp-4366	180	253	erlangen	erlangen	PROPN
fnp-4366	180	254	,	,	PUNCT
fnp-4366	180	255	fau	fau	PROPN
fnp-4366	180	256	erlangen	erlangen	PROPN
fnp-4366	180	257	-	-	PUNCT
fnp-4366	180	258	nürnberg	nürnberg	PROPN
fnp-4366	180	259	,	,	PUNCT
fnp-4366	180	260	erlangen	erlangen	PROPN
fnp-4366	180	261	,	,	PUNCT
fnp-4366	180	262	germany	germany	PROPN
fnp-4366	180	263	,	,	PUNCT
fnp-4366	180	264	and	and	CCONJ
fnp-4366	180	265	epicare	epicare	PROPN
fnp-4366	180	266	partner	partner	PROPN
fnp-4366	180	267	,	,	PUNCT
fnp-4366	180	268	erlangen	erlangen	PROPN
fnp-4366	180	269	,	,	PUNCT
fnp-4366	180	270	germany	germany	PROPN
fnp-4366	180	271	10	10	NUM
fnp-4366	180	272	department	department	NOUN
fnp-4366	180	273	of	of	ADP
fnp-4366	180	274	neurosurgery	neurosurgery	NOUN
fnp-4366	180	275	,	,	PUNCT
fnp-4366	180	276	medical	medical	ADJ
fnp-4366	180	277	university	university	PROPN
fnp-4366	180	278	of	of	ADP
fnp-4366	180	279	vienna	vienna	PROPN
fnp-4366	180	280	,	,	PUNCT
fnp-4366	180	281	vienna	vienna	PROPN
fnp-4366	180	282	general	general	PROPN
fnp-4366	180	283	hospital	hospital	PROPN
fnp-4366	180	284	,	,	PUNCT
fnp-4366	180	285	vienna	vienna	PROPN
fnp-4366	180	286	,	,	PUNCT
fnp-4366	180	287	austria	austria	PROPN
fnp-4366	180	288	,	,	PUNCT
fnp-4366	180	289	vienna	vienna	PROPN
fnp-4366	180	290	,	,	PUNCT
fnp-4366	180	291	austria	austria	PROPN
fnp-4366	180	292	background	background	NOUN
fnp-4366	180	293	:	:	PUNCT
fnp-4366	180	294	the	the	DET
fnp-4366	180	295	ptpn11	ptpn11	NOUN
fnp-4366	180	296	gene	gene	NOUN
fnp-4366	180	297	is	be	AUX
fnp-4366	180	298	a	a	DET
fnp-4366	180	299	tyrosine	tyrosine	NOUN
fnp-4366	180	300	phosphatase	phosphatase	NOUN
fnp-4366	180	301	non	non	ADJ
fnp-4366	180	302	-	-	ADJ
fnp-4366	180	303	receptor	receptor	ADJ
fnp-4366	180	304	type	type	NOUN
fnp-4366	180	305	protein	protein	NOUN
fnp-4366	180	306	linked	link	VERB
fnp-4366	180	307	to	to	ADP
fnp-4366	180	308	the	the	DET
fnp-4366	180	309	map	map	NOUN
fnp-4366	180	310	kinase	kinase	NOUN
fnp-4366	180	311	signaling	signal	VERB
fnp-4366	180	312	pathway	pathway	NOUN
fnp-4366	180	313	.	.	PUNCT
fnp-4366	181	1	it	it	PRON
fnp-4366	181	2	was	be	AUX
fnp-4366	181	3	recently	recently	ADV
fnp-4366	181	4	discovered	discover	VERB
fnp-4366	181	5	as	as	ADP
fnp-4366	181	6	novel	novel	ADJ
fnp-4366	181	7	lesional	lesional	ADJ
fnp-4366	181	8	epilepsy	epilepsy	NOUN
fnp-4366	181	9	gene	gene	NOUN
fnp-4366	181	10	by	by	ADP
fnp-4366	181	11	large	large	ADJ
fnp-4366	181	12	exome	exome	NOUN
fnp-4366	181	13	-	-	PUNCT
fnp-4366	181	14	wide	wide	ADJ
fnp-4366	181	15	sequencing	sequence	VERB
fnp-4366	181	16	studies	study	NOUN
fnp-4366	181	17	.	.	PUNCT
fnp-4366	182	1	ptpn11	ptpn11	PROPN
fnp-4366	182	2	germline	germline	NOUN
fnp-4366	182	3	mutations	mutation	NOUN
fnp-4366	182	4	have	have	AUX
fnp-4366	182	5	been	be	AUX
fnp-4366	182	6	associated	associate	VERB
fnp-4366	182	7	with	with	ADP
fnp-4366	182	8	noonan	noonan	PROPN
fnp-4366	182	9	syndrome	syndrome	PROPN
fnp-4366	182	10	,	,	PUNCT
fnp-4366	182	11	a	a	DET
fnp-4366	182	12	multisystem	multisystem	NOUN
fnp-4366	182	13	disorder	disorder	NOUN
fnp-4366	182	14	characterized	characterize	VERB
fnp-4366	182	15	by	by	ADP
fnp-4366	182	16	facial	facial	ADJ
fnp-4366	182	17	features	feature	NOUN
fnp-4366	182	18	,	,	PUNCT
fnp-4366	182	19	developmental	developmental	ADJ
fnp-4366	182	20	delay	delay	NOUN
fnp-4366	182	21	and	and	CCONJ
fnp-4366	182	22	other	other	ADJ
fnp-4366	182	23	organ	organ	NOUN
fnp-4366	182	24	diseases	disease	NOUN
fnp-4366	182	25	.	.	PUNCT
fnp-4366	183	1	sporadically	sporadically	ADV
fnp-4366	183	2	,	,	PUNCT
fnp-4366	183	3	low	low	ADJ
fnp-4366	183	4	-	-	PUNCT
fnp-4366	183	5	grade	grade	NOUN
fnp-4366	183	6	epilepsy	epilepsy	NOUN
fnp-4366	183	7	-	-	PUNCT
fnp-4366	183	8	associated	associate	VERB
fnp-4366	183	9	brain	brain	NOUN
fnp-4366	183	10	tumors	tumor	NOUN
fnp-4366	183	11	(	(	PUNCT
fnp-4366	183	12	leat	leat	NOUN
fnp-4366	183	13	)	)	PUNCT
fnp-4366	183	14	also	also	ADV
fnp-4366	183	15	occur	occur	VERB
fnp-4366	183	16	in	in	ADP
fnp-4366	183	17	noonan	noonan	PROPN
fnp-4366	183	18	patients	patient	NOUN
fnp-4366	183	19	.	.	PUNCT
fnp-4366	184	1	herein	herein	NOUN
fnp-4366	184	2	,	,	PUNCT
fnp-4366	184	3	we	we	PRON
fnp-4366	184	4	performed	perform	VERB
fnp-4366	184	5	a	a	DET
fnp-4366	184	6	first	first	ADJ
fnp-4366	184	7	deep	deep	ADJ
fnp-4366	184	8	phenotype	phenotype	NOUN
fnp-4366	184	9	-	-	PUNCT
fnp-4366	184	10	genotype	genotype	NOUN
fnp-4366	184	11	analysis	analysis	NOUN
fnp-4366	184	12	of	of	ADP
fnp-4366	184	13	low	low	ADJ
fnp-4366	184	14	-	-	PUNCT
fnp-4366	184	15	grade	grade	NOUN
fnp-4366	184	16	developmental	developmental	ADJ
fnp-4366	184	17	brain	brain	NOUN
fnp-4366	184	18	tumours	tumour	NOUN
fnp-4366	184	19	with	with	ADP
fnp-4366	184	20	brain	brain	NOUN
fnp-4366	184	21	somatic	somatic	ADJ
fnp-4366	184	22	alterations	alteration	NOUN
fnp-4366	184	23	of	of	ADP
fnp-4366	184	24	the	the	DET
fnp-4366	184	25	ptpn11	ptpn11	NOUN
fnp-4366	184	26	gene	gene	NOUN
fnp-4366	184	27	as	as	SCONJ
fnp-4366	184	28	compared	compare	VERB
fnp-4366	184	29	to	to	ADP
fnp-4366	184	30	commonly	commonly	ADV
fnp-4366	184	31	observed	observe	VERB
fnp-4366	184	32	leat	leat	NOUN
fnp-4366	184	33	with	with	ADP
fnp-4366	184	34	or	or	CCONJ
fnp-4366	184	35	without	without	ADP
fnp-4366	184	36	map	map	NOUN
fnp-4366	184	37	kinase	kinase	NOUN
fnp-4366	184	38	signaling	signal	VERB
fnp-4366	184	39	pathway	pathway	NOUN
fnp-4366	184	40	alterations	alteration	NOUN
fnp-4366	184	41	.	.	PUNCT
fnp-4366	185	1	methods	method	NOUN
fnp-4366	185	2	:	:	PUNCT
fnp-4366	185	3	we	we	PRON
fnp-4366	185	4	selected	select	VERB
fnp-4366	185	5	87	87	NUM
fnp-4366	185	6	leat	leat	NOUN
fnp-4366	185	7	cases	case	NOUN
fnp-4366	185	8	recently	recently	ADV
fnp-4366	185	9	submitted	submit	VERB
fnp-4366	185	10	to	to	ADP
fnp-4366	185	11	whole	whole	ADJ
fnp-4366	185	12	exome	exome	NOUN
fnp-4366	185	13	sequencing	sequence	VERB
fnp-4366	185	14	and	and	CCONJ
fnp-4366	185	15	genotyping	genotyping	NOUN
fnp-4366	185	16	including	include	VERB
fnp-4366	185	17	17	17	NUM
fnp-4366	185	18	dysembryoplastic	dysembryoplastic	ADJ
fnp-4366	185	19	neuroepithelial	neuroepithelial	ADJ
fnp-4366	185	20	tumours	tumour	NOUN
fnp-4366	185	21	(	(	PUNCT
fnp-4366	185	22	dnt	dnt	PROPN
fnp-4366	185	23	)	)	PUNCT
fnp-4366	185	24	and	and	CCONJ
fnp-4366	185	25	70	70	NUM
fnp-4366	185	26	ganglioglioma	ganglioglioma	NOUN
fnp-4366	185	27	(	(	PUNCT
fnp-4366	185	28	gg	gg	PROPN
fnp-4366	185	29	)	)	PUNCT
fnp-4366	185	30	.	.	PUNCT
fnp-4366	186	1	clinical	clinical	ADJ
fnp-4366	186	2	data	datum	NOUN
fnp-4366	186	3	were	be	AUX
fnp-4366	186	4	retrieved	retrieve	VERB
fnp-4366	186	5	from	from	ADP
fnp-4366	186	6	hospital	hospital	NOUN
fnp-4366	186	7	files	file	NOUN
fnp-4366	186	8	including	include	VERB
fnp-4366	186	9	postsurgical	postsurgical	ADJ
fnp-4366	186	10	outcome	outcome	NOUN
fnp-4366	186	11	(	(	PUNCT
fnp-4366	186	12	engel	engel	PROPN
fnp-4366	186	13	outcome	outcome	PROPN
fnp-4366	186	14	,	,	PUNCT
fnp-4366	186	15	seizure	seizure	NOUN
fnp-4366	186	16	onset	onset	NOUN
fnp-4366	186	17	,	,	PUNCT
fnp-4366	186	18	age	age	NOUN
fnp-4366	186	19	at	at	ADP
fnp-4366	186	20	surgery	surgery	NOUN
fnp-4366	186	21	,	,	PUNCT
fnp-4366	186	22	mri	mri	NOUN
fnp-4366	186	23	findings	finding	NOUN
fnp-4366	186	24	,	,	PUNCT
fnp-4366	186	25	location	location	NOUN
fnp-4366	186	26	)	)	PUNCT
fnp-4366	186	27	.	.	PUNCT
fnp-4366	187	1	available	available	ADJ
fnp-4366	187	2	histopathology	histopathology	NOUN
fnp-4366	187	3	slides	slide	NOUN
fnp-4366	187	4	were	be	AUX
fnp-4366	187	5	fully	fully	ADV
fnp-4366	187	6	digitalized	digitalize	VERB
fnp-4366	187	7	for	for	ADP
fnp-4366	187	8	systematic	systematic	ADJ
fnp-4366	187	9	microscopy	microscopy	NOUN
fnp-4366	187	10	analysis	analysis	NOUN
fnp-4366	187	11	,	,	PUNCT
fnp-4366	187	12	including	include	VERB
fnp-4366	187	13	h&e	h&e	PROPN
fnp-4366	187	14	and	and	CCONJ
fnp-4366	187	15	immunohistochemistry	immunohistochemistry	NOUN
fnp-4366	187	16	for	for	ADP
fnp-4366	187	17	cd34	cd34	PROPN
fnp-4366	187	18	,	,	PUNCT
fnp-4366	187	19	p16	p16	NOUN
fnp-4366	187	20	,	,	PUNCT
fnp-4366	187	21	map2	map2	NOUN
fnp-4366	187	22	,	,	PUNCT
fnp-4366	187	23	neun	neun	NOUN
fnp-4366	187	24	,	,	PUNCT
fnp-4366	187	25	ki67	ki67	PROPN
fnp-4366	187	26	,	,	PUNCT
fnp-4366	187	27	idh1	idh1	PROPN
fnp-4366	187	28	and	and	CCONJ
fnp-4366	187	29	p53	p53	PROPN
fnp-4366	187	30	.	.	PUNCT
fnp-4366	188	1	results	result	NOUN
fnp-4366	188	2	:	:	PUNCT
fnp-4366	188	3	we	we	PRON
fnp-4366	188	4	identified	identify	VERB
fnp-4366	188	5	a	a	DET
fnp-4366	188	6	series	series	NOUN
fnp-4366	188	7	of	of	ADP
fnp-4366	188	8	eight	eight	NUM
fnp-4366	188	9	gg	gg	NOUN
fnp-4366	188	10	with	with	ADP
fnp-4366	188	11	ptpn11	ptpn11	NOUN
fnp-4366	188	12	alterations	alteration	NOUN
fnp-4366	188	13	,	,	PUNCT
fnp-4366	188	14	i.e.	i.e.	X
fnp-4366	188	15	gains	gain	NOUN
fnp-4366	188	16	in	in	ADP
fnp-4366	188	17	copy	copy	NOUN
fnp-4366	188	18	number	number	NOUN
fnp-4366	188	19	variations	variation	NOUN
fnp-4366	188	20	(	(	PUNCT
fnp-4366	188	21	cnv	cnv	NOUN
fnp-4366	188	22	)	)	PUNCT
fnp-4366	188	23	of	of	ADP
fnp-4366	188	24	the	the	DET
fnp-4366	188	25	locus	locus	NOUN
fnp-4366	188	26	12q	12q	NOUN
fnp-4366	188	27	,	,	PUNCT
fnp-4366	188	28	which	which	PRON
fnp-4366	188	29	showed	show	VERB
fnp-4366	188	30	a	a	DET
fnp-4366	188	31	systematic	systematic	ADJ
fnp-4366	188	32	pattern	pattern	NOUN
fnp-4366	188	33	of	of	ADP
fnp-4366	188	34	additional	additional	ADJ
fnp-4366	188	35	cnv	cnv	NOUN
fnp-4366	188	36	gains	gain	NOUN
fnp-4366	188	37	in	in	ADP
fnp-4366	188	38	fgfr4	fgfr4	PROPN
fnp-4366	188	39	,	,	PUNCT
fnp-4366	188	40	rheb	rheb	NOUN
fnp-4366	188	41	,	,	PUNCT
fnp-4366	188	42	nf1	nf1	NOUN
fnp-4366	188	43	,	,	PUNCT
fnp-4366	188	44	kras	kra	NOUN
fnp-4366	188	45	as	as	ADV
fnp-4366	188	46	well	well	ADV
fnp-4366	188	47	as	as	ADP
fnp-4366	188	48	braf	braf	NOUN
fnp-4366	188	49	alterations	alteration	NOUN
fnp-4366	188	50	(	(	PUNCT
fnp-4366	188	51	figure	figure	NOUN
fnp-4366	188	52	1	1	NUM
fnp-4366	188	53	)	)	PUNCT
fnp-4366	188	54	.	.	PUNCT
fnp-4366	189	1	histopathology	histopathology	NOUN
fnp-4366	189	2	pattern	pattern	NOUN
fnp-4366	189	3	analysis	analysis	NOUN
fnp-4366	189	4	revealed	reveal	VERB
fnp-4366	189	5	an	an	DET
fnp-4366	189	6	atypical	atypical	ADJ
fnp-4366	189	7	and	and	CCONJ
fnp-4366	189	8	complex	complex	ADJ
fnp-4366	189	9	glio	glio	ADJ
fnp-4366	189	10	-	-	PUNCT
fnp-4366	189	11	neuronal	neuronal	ADJ
fnp-4366	189	12	phenotype	phenotype	NOUN
fnp-4366	189	13	with	with	ADP
fnp-4366	189	14	subpial	subpial	ADJ
fnp-4366	189	15	tumour	tumour	NOUN
fnp-4366	189	16	spread	spread	NOUN
fnp-4366	189	17	and	and	CCONJ
fnp-4366	189	18	large	large	ADJ
fnp-4366	189	19	,	,	PUNCT
fnp-4366	189	20	pleomorphic	pleomorphic	ADJ
fnp-4366	189	21	and	and	CCONJ
fnp-4366	189	22	multinuclear	multinuclear	ADJ
fnp-4366	189	23	cellular	cellular	ADJ
fnp-4366	189	24	features	feature	NOUN
fnp-4366	189	25	(	(	PUNCT
fnp-4366	189	26	figure	figure	NOUN
fnp-4366	189	27	2	2	NUM
fnp-4366	189	28	)	)	PUNCT
fnp-4366	189	29	.	.	PUNCT
fnp-4366	190	1	only	only	ADV
fnp-4366	190	2	three	three	NUM
fnp-4366	190	3	out	out	ADP
fnp-4366	190	4	of	of	ADP
fnp-4366	190	5	eight	eight	NUM
fnp-4366	190	6	gg	gg	NOUN
fnp-4366	190	7	with	with	ADP
fnp-4366	190	8	ptpn11	ptpn11	NOUN
fnp-4366	190	9	alterations	alteration	NOUN
fnp-4366	190	10	were	be	AUX
fnp-4366	190	11	free	free	ADJ
fnp-4366	190	12	of	of	ADP
fnp-4366	190	13	disabling	disable	VERB
fnp-4366	190	14	-	-	PUNCT
fnp-4366	190	15	seizures	seizure	NOUN
fnp-4366	190	16	two	two	NUM
fnp-4366	190	17	years	year	NOUN
fnp-4366	190	18	after	after	ADP
fnp-4366	190	19	surgery	surgery	NOUN
fnp-4366	190	20	(	(	PUNCT
fnp-4366	190	21	engel	engel	PROPN
fnp-4366	190	22	ia	ia	PROPN
fnp-4366	190	23	outcome	outcome	PROPN
fnp-4366	190	24	,	,	PUNCT
fnp-4366	190	25	38	38	NUM
fnp-4366	190	26	%	%	NOUN
fnp-4366	190	27	)	)	PUNCT
fnp-4366	190	28	.	.	PUNCT
fnp-4366	191	1	this	this	PRON
fnp-4366	191	2	was	be	AUX
fnp-4366	191	3	remarkably	remarkably	ADV
fnp-4366	191	4	different	different	ADJ
fnp-4366	191	5	from	from	ADP
fnp-4366	191	6	our	our	PRON
fnp-4366	191	7	series	series	NOUN
fnp-4366	191	8	of	of	ADP
fnp-4366	191	9	gg	gg	PROPN
fnp-4366	191	10	with	with	ADP
fnp-4366	191	11	braf	braf	NOUN
fnp-4366	191	12	alterations	alteration	NOUN
fnp-4366	191	13	(	(	PUNCT
fnp-4366	191	14	n=35	n=35	PROPN
fnp-4366	191	15	)	)	PUNCT
fnp-4366	191	16	,	,	PUNCT
fnp-4366	191	17	gg	gg	NOUN
fnp-4366	191	18	without	without	ADP
fnp-4366	191	19	any	any	DET
fnp-4366	191	20	genetic	genetic	ADJ
fnp-4366	191	21	alteration	alteration	NOUN
fnp-4366	191	22	detectable	detectable	ADJ
fnp-4366	191	23	by	by	ADP
fnp-4366	191	24	our	our	PRON
fnp-4366	191	25	study	study	NOUN
fnp-4366	191	26	paradigm	paradigm	NOUN
fnp-4366	191	27	(	(	PUNCT
fnp-4366	191	28	n=27	n=27	PROPN
fnp-4366	191	29	)	)	PUNCT
fnp-4366	191	30	and	and	CCONJ
fnp-4366	191	31	dnt	dnt	VERB
fnp-4366	191	32	with	with	ADP
fnp-4366	191	33	fgfr1	fgfr1	NOUN
fnp-4366	191	34	alterations	alteration	NOUN
fnp-4366	191	35	(	(	PUNCT
fnp-4366	191	36	n=6	n=6	NOUN
fnp-4366	191	37	)	)	PUNCT
fnp-4366	191	38	with	with	ADP
fnp-4366	191	39	engel	engel	PROPN
fnp-4366	191	40	ia	ia	PROPN
fnp-4366	191	41	rates	rate	NOUN
fnp-4366	191	42	of	of	ADP
fnp-4366	191	43	85	85	NUM
fnp-4366	191	44	%	%	NOUN
fnp-4366	191	45	,	,	PUNCT
fnp-4366	191	46	76	76	NUM
fnp-4366	191	47	%	%	NOUN
fnp-4366	191	48	and	and	CCONJ
fnp-4366	191	49	83	83	NUM
fnp-4366	191	50	%	%	NOUN
fnp-4366	191	51	,	,	PUNCT
fnp-4366	191	52	respectively	respectively	ADV
fnp-4366	191	53	.	.	PUNCT
fnp-4366	192	1	conclusions	conclusion	NOUN
fnp-4366	192	2	:	:	PUNCT
fnp-4366	192	3	we	we	PRON
fnp-4366	192	4	identified	identify	VERB
fnp-4366	192	5	a	a	DET
fnp-4366	192	6	subgroup	subgroup	NOUN
fnp-4366	192	7	of	of	ADP
fnp-4366	192	8	ganglioglioma	ganglioglioma	NOUN
fnp-4366	192	9	characterized	characterize	VERB
fnp-4366	192	10	by	by	ADP
fnp-4366	192	11	ptpn11	ptpn11	NOUN
fnp-4366	192	12	alterations	alteration	NOUN
fnp-4366	192	13	in	in	ADP
fnp-4366	192	14	association	association	NOUN
fnp-4366	192	15	with	with	ADP
fnp-4366	192	16	other	other	ADJ
fnp-4366	192	17	noonan	noonan	PROPN
fnp-4366	192	18	syndrome	syndrome	PROPN
fnp-4366	192	19	related	relate	VERB
fnp-4366	192	20	alterations	alteration	NOUN
fnp-4366	192	21	of	of	ADP
fnp-4366	192	22	the	the	DET
fnp-4366	192	23	map	map	NOUN
fnp-4366	192	24	kinase	kinase	NOUN
fnp-4366	192	25	signaling	signal	VERB
fnp-4366	192	26	pathway	pathway	NOUN
fnp-4366	192	27	,	,	PUNCT
fnp-4366	192	28	i.e.	i.e.	X
fnp-4366	192	29	,	,	PUNCT
fnp-4366	192	30	kras	kra	NOUN
fnp-4366	192	31	,	,	PUNCT
fnp-4366	192	32	rheb	rheb	ADJ
fnp-4366	192	33	,	,	PUNCT
fnp-4366	192	34	braf	braf	NOUN
fnp-4366	192	35	,	,	PUNCT
fnp-4366	192	36	and	and	CCONJ
fnp-4366	192	37	fgfr4	fgfr4	PROPN
fnp-4366	192	38	.	.	PUNCT
fnp-4366	193	1	these	these	DET
fnp-4366	193	2	tumours	tumour	NOUN
fnp-4366	193	3	were	be	AUX
fnp-4366	193	4	further	far	ADV
fnp-4366	193	5	characterized	characterize	VERB
fnp-4366	193	6	by	by	ADP
fnp-4366	193	7	histopathological	histopathological	ADJ
fnp-4366	193	8	features	feature	NOUN
fnp-4366	193	9	of	of	ADP
fnp-4366	193	10	cellular	cellular	ADJ
fnp-4366	193	11	atypia	atypia	NOUN
fnp-4366	193	12	in	in	ADP
fnp-4366	193	13	glial	glial	ADJ
fnp-4366	193	14	and	and	CCONJ
fnp-4366	193	15	neuronal	neuronal	ADJ
fnp-4366	193	16	cell	cell	NOUN
fnp-4366	193	17	components	component	NOUN
fnp-4366	193	18	as	as	ADV
fnp-4366	193	19	well	well	ADV
fnp-4366	193	20	as	as	ADP
fnp-4366	193	21	adverse	adverse	ADJ
fnp-4366	193	22	postsurgical	postsurgical	ADJ
fnp-4366	193	23	outcome	outcome	NOUN
fnp-4366	193	24	.	.	PUNCT
fnp-4366	194	1	these	these	DET
fnp-4366	194	2	features	feature	NOUN
fnp-4366	194	3	were	be	AUX
fnp-4366	194	4	strikingly	strikingly	ADV
fnp-4366	194	5	different	different	ADJ
fnp-4366	194	6	from	from	ADP
fnp-4366	194	7	other	other	ADJ
fnp-4366	194	8	leat	leat	NOUN
fnp-4366	194	9	with	with	ADP
fnp-4366	194	10	defined	define	VERB
fnp-4366	194	11	genetic	genetic	ADJ
fnp-4366	194	12	alterations	alteration	NOUN
fnp-4366	194	13	in	in	ADP
fnp-4366	194	14	braf	braf	NOUN
fnp-4366	194	15	,	,	PUNCT
fnp-4366	194	16	e.g.	e.g.	ADV
fnp-4366	194	17	,	,	PUNCT
fnp-4366	194	18	v600e	v600e	NOUN
fnp-4366	194	19	mutation	mutation	NOUN
fnp-4366	194	20	,	,	PUNCT
fnp-4366	194	21	and	and	CCONJ
fnp-4366	194	22	fgfr1	fgfr1	PROPN
fnp-4366	194	23	.	.	PUNCT
fnp-4366	195	1	notwithstanding	notwithstanding	ADP
fnp-4366	195	2	,	,	PUNCT
fnp-4366	195	3	these	these	DET
fnp-4366	195	4	findings	finding	NOUN
fnp-4366	195	5	need	need	VERB
fnp-4366	195	6	further	further	ADJ
fnp-4366	195	7	validation	validation	NOUN
fnp-4366	195	8	as	as	SCONJ
fnp-4366	195	9	they	they	PRON
fnp-4366	195	10	argue	argue	VERB
fnp-4366	195	11	for	for	ADP
fnp-4366	195	12	a	a	DET
fnp-4366	195	13	three	three	NUM
fnp-4366	195	14	-	-	PUNCT
fnp-4366	195	15	tiered	tiere	VERB
fnp-4366	195	16	who	who	PRON
fnp-4366	195	17	grading	grade	VERB
fnp-4366	195	18	system	system	NOUN
fnp-4366	195	19	also	also	ADV
fnp-4366	195	20	for	for	ADP
fnp-4366	195	21	developmental	developmental	ADJ
fnp-4366	195	22	,	,	PUNCT
fnp-4366	195	23	glio	glio	ADJ
fnp-4366	195	24	-	-	PUNCT
fnp-4366	195	25	neuronal	neuronal	ADJ
fnp-4366	195	26	tumors	tumor	NOUN
fnp-4366	195	27	associated	associate	VERB
fnp-4366	195	28	with	with	ADP
fnp-4366	195	29	early	early	ADJ
fnp-4366	195	30	-	-	PUNCT
fnp-4366	195	31	onset	onset	ADJ
fnp-4366	195	32	focal	focal	ADJ
fnp-4366	195	33	epilepsy	epilepsy	NOUN
fnp-4366	195	34	.	.	PUNCT
fnp-4366	196	1	genetic	genetic	ADJ
fnp-4366	196	2	similarities	similarity	NOUN
fnp-4366	196	3	to	to	ADP
fnp-4366	196	4	noonan	noonan	PROPN
fnp-4366	196	5	syndrome	syndrome	PROPN
fnp-4366	196	6	and	and	CCONJ
fnp-4366	196	7	noonan	noonan	PROPN
fnp-4366	196	8	syndrome	syndrome	PROPN
fnp-4366	196	9	associated	associate	VERB
fnp-4366	196	10	disorders	disorder	NOUN
fnp-4366	196	11	may	may	AUX
fnp-4366	196	12	also	also	ADV
fnp-4366	196	13	suggest	suggest	VERB
fnp-4366	196	14	the	the	DET
fnp-4366	196	15	use	use	NOUN
fnp-4366	196	16	of	of	ADP
fnp-4366	196	17	targeted	target	VERB
fnp-4366	196	18	treatment	treatment	NOUN
fnp-4366	196	19	options	option	NOUN
fnp-4366	196	20	against	against	ADP
fnp-4366	196	21	the	the	DET
fnp-4366	196	22	map	map	NOUN
fnp-4366	196	23	kinase	kinase	NOUN
fnp-4366	196	24	and	and	CCONJ
fnp-4366	196	25	mtor	mtor	PROPN
fnp-4366	196	26	signaling	signal	VERB
fnp-4366	196	27	pathway	pathway	NOUN
fnp-4366	196	28	.	.	PUNCT
fnp-4366	197	1	figure	figure	VERB
fnp-4366	197	2	1	1	NUM
fnp-4366	197	3	:	:	PUNCT
fnp-4366	197	4	oncoplot	oncoplot	NOUN
fnp-4366	197	5	of	of	ADP
fnp-4366	197	6	ptpn11	ptpn11	PROPN
fnp-4366	197	7	altered	alter	VERB
fnp-4366	197	8	leat	leat	NOUN
fnp-4366	197	9	compared	compare	VERB
fnp-4366	197	10	to	to	ADP
fnp-4366	197	11	a	a	DET
fnp-4366	197	12	braf	braf	NOUN
fnp-4366	197	13	-	-	PUNCT
fnp-4366	197	14	v600e	v600e	VERB
fnp-4366	197	15	mutated	mutate	VERB
fnp-4366	197	16	gg	gg	NOUN
fnp-4366	197	17	(	(	PUNCT
fnp-4366	197	18	arrow	arrow	NOUN
fnp-4366	197	19	on	on	ADP
fnp-4366	197	20	left	left	NOUN
fnp-4366	197	21	)	)	PUNCT
fnp-4366	197	22	and	and	CCONJ
fnp-4366	197	23	a	a	DET
fnp-4366	197	24	fgfr1	fgfr1	NOUN
fnp-4366	197	25	altered	alter	VERB
fnp-4366	197	26	dnt	dnt	PROPN
fnp-4366	197	27	(	(	PUNCT
fnp-4366	197	28	arrow	arrow	NOUN
fnp-4366	197	29	on	on	ADP
fnp-4366	197	30	right	right	ADJ
fnp-4366	197	31	)	)	PUNCT
fnp-4366	197	32	figure	figure	NOUN
fnp-4366	197	33	2	2	NUM
fnp-4366	197	34	:	:	PUNCT
fnp-4366	197	35	histopathology	histopathology	NOUN
fnp-4366	197	36	findings	finding	NOUN
fnp-4366	197	37	in	in	ADP
fnp-4366	197	38	a	a	DET
fnp-4366	197	39	ptpn11	ptpn11	NOUN
fnp-4366	197	40	altered	alter	VERB
fnp-4366	197	41	atypical	atypical	ADJ
fnp-4366	197	42	ganglioglioma	ganglioglioma	NOUN
fnp-4366	197	43	.	.	PUNCT
fnp-4366	198	1	a	a	DET
fnp-4366	198	2	:	:	PUNCT
fnp-4366	198	3	subpial	subpial	ADJ
fnp-4366	198	4	growth	growth	NOUN
fnp-4366	198	5	(	(	PUNCT
fnp-4366	198	6	arrow	arrow	NOUN
fnp-4366	198	7	)	)	PUNCT
fnp-4366	198	8	with	with	ADP
fnp-4366	198	9	large	large	ADJ
fnp-4366	198	10	,	,	PUNCT
fnp-4366	198	11	pleomorphic	pleomorphic	ADJ
fnp-4366	198	12	and	and	CCONJ
fnp-4366	198	13	glio	glio	ADJ
fnp-4366	198	14	-	-	PUNCT
fnp-4366	198	15	neuronal	neuronal	ADJ
fnp-4366	198	16	phenotype	phenotype	NOUN
fnp-4366	198	17	shown	show	VERB
fnp-4366	198	18	in	in	ADP
fnp-4366	198	19	b.	b.	PROPN
fnp-4366	199	1	c	c	X
fnp-4366	199	2	:	:	PUNCT
fnp-4366	199	3	abundant	abundant	ADJ
fnp-4366	199	4	cd34	cd34	PROPN
fnp-4366	199	5	immunoreactivity	immunoreactivity	NOUN
fnp-4366	199	6	(	(	PUNCT
fnp-4366	199	7	sp	sp	ADP
fnp-4366	199	8	–	–	PUNCT
fnp-4366	199	9	subpial	subpial	ADJ
fnp-4366	199	10	region	region	NOUN
fnp-4366	199	11	)	)	PUNCT
fnp-4366	199	12	.	.	PUNCT
fnp-4366	200	1	d	d	X
fnp-4366	200	2	:	:	PUNCT
fnp-4366	200	3	the	the	DET
fnp-4366	200	4	arrow	arrow	NOUN
fnp-4366	200	5	points	point	NOUN
fnp-4366	200	6	to	to	ADP
fnp-4366	200	7	a	a	DET
fnp-4366	200	8	bi	bi	ADJ
fnp-4366	200	9	-	-	ADJ
fnp-4366	200	10	nucleated	nucleated	ADJ
fnp-4366	200	11	neuron	neuron	NOUN
fnp-4366	200	12	(	(	PUNCT
fnp-4366	200	13	map2	map2	NOUN
fnp-4366	200	14	immunohistochemistry	immunohistochemistry	NOUN
fnp-4366	200	15	)	)	PUNCT
fnp-4366	200	16	confirming	confirm	VERB
fnp-4366	200	17	the	the	DET
fnp-4366	200	18	diagnosis	diagnosis	NOUN
fnp-4366	200	19	of	of	ADP
fnp-4366	200	20	ganglioglioma	ganglioglioma	NOUN
fnp-4366	200	21	.	.	PUNCT
fnp-4366	200	22	  	  	SPACE
fnp-4366	201	1	2.04	2.04	NUM
fnp-4366	201	2	free	free	ADJ
fnp-4366	201	3	neuropathol	neuropathol	NOUN
fnp-4366	201	4	3:20:23	3:20:23	NUM
fnp-4366	201	5	molecular	molecular	ADJ
fnp-4366	201	6	refinement	refinement	NOUN
fnp-4366	201	7	of	of	ADP
fnp-4366	201	8	pilocytic	pilocytic	ADJ
fnp-4366	201	9	astrocytoma	astrocytoma	NOUN
fnp-4366	201	10	in	in	ADP
fnp-4366	201	11	adult	adult	NOUN
fnp-4366	201	12	patients	patient	NOUN
fnp-4366	201	13	helena	helena	PROPN
fnp-4366	201	14	bode1,2	bode1,2	PROPN
fnp-4366	201	15	,	,	PUNCT
fnp-4366	201	16	catena	catena	PROPN
fnp-4366	201	17	kresbach1,2,3	kresbach1,2,3	PROPN
fnp-4366	201	18	,	,	PUNCT
fnp-4366	201	19	dörthe	dörthe	DET
fnp-4366	201	20	holdhof1,2	holdhof1,2	PROPN
fnp-4366	201	21	,	,	PUNCT
fnp-4366	201	22	mario	mario	PROPN
fnp-4366	201	23	m.	m.	PROPN
fnp-4366	201	24	dorostkar4,5	dorostkar4,5	PROPN
fnp-4366	201	25	,	,	PUNCT
fnp-4366	201	26	patrick	patrick	PROPN
fnp-4366	201	27	n.	n.	PROPN
fnp-4366	201	28	harter6	harter6	PROPN
fnp-4366	201	29	,	,	PUNCT
fnp-4366	201	30	jürgen	jürgen	PROPN
fnp-4366	201	31	hench7	hench7	PROPN
fnp-4366	201	32	,	,	PUNCT
fnp-4366	201	33	stephan	stephan	PROPN
fnp-4366	201	34	frank7	frank7	PROPN
fnp-4366	201	35	,	,	PUNCT
fnp-4366	201	36	alicia	alicia	PROPN
fnp-4366	201	37	eckhardt1,2,8	eckhardt1,2,8	PROPN
fnp-4366	201	38	,	,	PUNCT
fnp-4366	201	39	annika	annika	PROPN
fnp-4366	201	40	k.	k.	PROPN
fnp-4366	201	41	wefers3	wefers3	PROPN
fnp-4366	201	42	,	,	PUNCT
fnp-4366	201	43	sina	sina	PROPN
fnp-4366	201	44	neyazi1,2	neyazi1,2	PROPN
fnp-4366	201	45	,	,	PUNCT
fnp-4366	201	46	david	david	PROPN
fnp-4366	201	47	capper9,10	capper9,10	PROPN
fnp-4366	201	48	,	,	PUNCT
fnp-4366	201	49	michael	michael	PROPN
fnp-4366	201	50	bockmayr1,2,11	bockmayr1,2,11	PROPN
fnp-4366	201	51	,	,	PUNCT
fnp-4366	201	52	ulrich	ulrich	PROPN
fnp-4366	201	53	schüller1,2,3	schüller1,2,3	PROPN
fnp-4366	201	54	1	1	NUM
fnp-4366	201	55	department	department	NOUN
fnp-4366	201	56	of	of	ADP
fnp-4366	201	57	pediatric	pediatric	ADJ
fnp-4366	201	58	hematology	hematology	NOUN
fnp-4366	201	59	and	and	CCONJ
fnp-4366	201	60	oncology	oncology	NOUN
fnp-4366	201	61	,	,	PUNCT
fnp-4366	201	62	university	university	NOUN
fnp-4366	201	63	medical	medical	ADJ
fnp-4366	201	64	center	center	PROPN
fnp-4366	201	65	hamburg	hamburg	PROPN
fnp-4366	201	66	-	-	PUNCT
fnp-4366	201	67	eppendorf	eppendorf	PROPN
fnp-4366	201	68	,	,	PUNCT
fnp-4366	201	69	hamburg	hamburg	PROPN
fnp-4366	201	70	,	,	PUNCT
fnp-4366	201	71	deutschland	deutschland	NOUN
fnp-4366	201	72	2	2	NUM
fnp-4366	201	73	research	research	NOUN
fnp-4366	201	74	institute	institute	NOUN
fnp-4366	201	75	children	child	NOUN
fnp-4366	201	76	’s	’s	PART
fnp-4366	201	77	cancer	cancer	NOUN
fnp-4366	201	78	center	center	PROPN
fnp-4366	201	79	hamburg	hamburg	PROPN
fnp-4366	201	80	,	,	PUNCT
fnp-4366	201	81	hamburg	hamburg	PROPN
fnp-4366	201	82	,	,	PUNCT
fnp-4366	201	83	deutschland	deutschland	PROPN
fnp-4366	201	84	3	3	NUM
fnp-4366	201	85	institute	institute	NOUN
fnp-4366	201	86	of	of	ADP
fnp-4366	201	87	neuropathology	neuropathology	NOUN
fnp-4366	201	88	,	,	PUNCT
fnp-4366	201	89	university	university	NOUN
fnp-4366	201	90	medical	medical	ADJ
fnp-4366	201	91	center	center	PROPN
fnp-4366	201	92	hamburg	hamburg	PROPN
fnp-4366	201	93	-	-	PUNCT
fnp-4366	201	94	eppendorf	eppendorf	PROPN
fnp-4366	201	95	,	,	PUNCT
fnp-4366	201	96	hamburg	hamburg	PROPN
fnp-4366	201	97	,	,	PUNCT
fnp-4366	201	98	deutschland	deutschland	NOUN
fnp-4366	201	99	4	4	NUM
fnp-4366	201	100	center	center	NOUN
fnp-4366	201	101	for	for	ADP
fnp-4366	201	102	neuropathology	neuropathology	NOUN
fnp-4366	201	103	,	,	PUNCT
fnp-4366	201	104	ludwig	ludwig	PROPN
fnp-4366	201	105	-	-	PUNCT
fnp-4366	201	106	maximilians	maximilians	PROPN
fnp-4366	201	107	-	-	PUNCT
fnp-4366	201	108	university	university	NOUN
fnp-4366	201	109	,	,	PUNCT
fnp-4366	201	110	munich	munich	PROPN
fnp-4366	201	111	,	,	PUNCT
fnp-4366	201	112	deutschland	deutschland	NOUN
fnp-4366	201	113	5	5	NUM
fnp-4366	201	114	german	german	ADJ
fnp-4366	201	115	center	center	NOUN
fnp-4366	201	116	for	for	ADP
fnp-4366	201	117	neurodegenerative	neurodegenerative	ADJ
fnp-4366	201	118	diseases	disease	NOUN
fnp-4366	201	119	,	,	PUNCT
fnp-4366	201	120	munich	munich	PROPN
fnp-4366	201	121	,	,	PUNCT
fnp-4366	201	122	deutschland	deutschland	PROPN
fnp-4366	201	123	6	6	NUM
fnp-4366	201	124	institute	institute	NOUN
fnp-4366	201	125	of	of	ADP
fnp-4366	201	126	neurology	neurology	NOUN
fnp-4366	201	127	(	(	PUNCT
fnp-4366	201	128	edinger	edinger	NOUN
fnp-4366	201	129	institut	institut	PROPN
fnp-4366	201	130	)	)	PUNCT
fnp-4366	201	131	,	,	PUNCT
fnp-4366	201	132	university	university	NOUN
fnp-4366	201	133	hospital	hospital	NOUN
fnp-4366	201	134	frankfurt	frankfurt	PROPN
fnp-4366	201	135	,	,	PUNCT
fnp-4366	201	136	frankfurt	frankfurt	PROPN
fnp-4366	201	137	,	,	PUNCT
fnp-4366	201	138	deutschland	deutschland	NOUN
fnp-4366	201	139	7	7	NUM
fnp-4366	201	140	division	division	NOUN
fnp-4366	201	141	of	of	ADP
fnp-4366	201	142	neuropathology	neuropathology	NOUN
fnp-4366	201	143	,	,	PUNCT
fnp-4366	201	144	institute	institute	NOUN
fnp-4366	201	145	of	of	ADP
fnp-4366	201	146	medical	medical	ADJ
fnp-4366	201	147	genetics	genetic	NOUN
fnp-4366	201	148	and	and	CCONJ
fnp-4366	201	149	pathology	pathology	NOUN
fnp-4366	201	150	,	,	PUNCT
fnp-4366	201	151	university	university	PROPN
fnp-4366	201	152	of	of	ADP
fnp-4366	201	153	basel	basel	PROPN
fnp-4366	201	154	,	,	PUNCT
fnp-4366	201	155	basel	basel	PROPN
fnp-4366	201	156	,	,	PUNCT
fnp-4366	201	157	switzerland	switzerland	PROPN
fnp-4366	201	158	8	8	NUM
fnp-4366	201	159	lab	lab	NOUN
fnp-4366	201	160	of	of	ADP
fnp-4366	201	161	radiobiology	radiobiology	NOUN
fnp-4366	201	162	&	&	CCONJ
fnp-4366	201	163	experimental	experimental	ADJ
fnp-4366	201	164	radiation	radiation	NOUN
fnp-4366	201	165	oncology	oncology	NOUN
fnp-4366	201	166	,	,	PUNCT
fnp-4366	201	167	hubertus	hubertus	PROPN
fnp-4366	201	168	wald	wald	PROPN
fnp-4366	201	169	tumorzentrum	tumorzentrum	PROPN
fnp-4366	201	170	–	–	PUNCT
fnp-4366	201	171	university	university	NOUN
fnp-4366	201	172	cancer	cancer	NOUN
fnp-4366	201	173	center	center	PROPN
fnp-4366	201	174	hamburg	hamburg	PROPN
fnp-4366	201	175	,	,	PUNCT
fnp-4366	201	176	university	university	NOUN
fnp-4366	201	177	medical	medical	ADJ
fnp-4366	201	178	center	center	PROPN
fnp-4366	201	179	hamburg	hamburg	PROPN
fnp-4366	201	180	-	-	PUNCT
fnp-4366	201	181	eppendorf	eppendorf	PROPN
fnp-4366	201	182	,	,	PUNCT
fnp-4366	201	183	hamburg	hamburg	PROPN
fnp-4366	201	184	,	,	PUNCT
fnp-4366	201	185	deutschland	deutschland	NOUN
fnp-4366	201	186	9	9	NUM
fnp-4366	201	187	german	german	ADJ
fnp-4366	201	188	cancer	cancer	NOUN
fnp-4366	201	189	consortium	consortium	NOUN
fnp-4366	201	190	(	(	PUNCT
fnp-4366	201	191	dktk	dktk	NOUN
fnp-4366	201	192	)	)	PUNCT
fnp-4366	201	193	,	,	PUNCT
fnp-4366	201	194	partner	partner	NOUN
fnp-4366	201	195	site	site	NOUN
fnp-4366	201	196	berlin	berlin	PROPN
fnp-4366	201	197	,	,	PUNCT
fnp-4366	201	198	and	and	CCONJ
fnp-4366	201	199	german	german	ADJ
fnp-4366	201	200	cancer	cancer	NOUN
fnp-4366	201	201	research	research	NOUN
fnp-4366	201	202	center	center	NOUN
fnp-4366	201	203	(	(	PUNCT
fnp-4366	201	204	dkfz	dkfz	PROPN
fnp-4366	201	205	)	)	PUNCT
fnp-4366	201	206	,	,	PUNCT
fnp-4366	201	207	heidelberg	heidelberg	PROPN
fnp-4366	201	208	,	,	PUNCT
fnp-4366	201	209	deutschland	deutschland	NOUN
fnp-4366	201	210	10	10	NUM
fnp-4366	201	211	department	department	NOUN
fnp-4366	201	212	of	of	ADP
fnp-4366	201	213	neuropathology	neuropathology	NOUN
fnp-4366	201	214	,	,	PUNCT
fnp-4366	201	215	corporate	corporate	ADJ
fnp-4366	201	216	member	member	NOUN
fnp-4366	201	217	of	of	ADP
fnp-4366	201	218	freie	freie	PROPN
fnp-4366	201	219	universität	universität	PROPN
fnp-4366	201	220	berlin	berlin	PROPN
fnp-4366	201	221	,	,	PUNCT
fnp-4366	201	222	charité	charité	PROPN
fnp-4366	201	223	,	,	PUNCT
fnp-4366	201	224	universitätsmedizin	universitätsmedizin	PROPN
fnp-4366	201	225	berlin	berlin	PROPN
fnp-4366	201	226	and	and	CCONJ
fnp-4366	201	227	humboldt	humboldt	PROPN
fnp-4366	201	228	-	-	PUNCT
fnp-4366	201	229	universität	universität	PROPN
fnp-4366	201	230	zu	zu	PROPN
fnp-4366	201	231	berlin	berlin	PROPN
fnp-4366	201	232	,	,	PUNCT
fnp-4366	201	233	berlin	berlin	PROPN
fnp-4366	201	234	,	,	PUNCT
fnp-4366	201	235	deutschland	deutschland	PROPN
fnp-4366	201	236	11	11	NUM
fnp-4366	201	237	institute	institute	NOUN
fnp-4366	201	238	of	of	ADP
fnp-4366	201	239	pathology	pathology	PROPN
fnp-4366	201	240	,	,	PUNCT
fnp-4366	201	241	corporate	corporate	ADJ
fnp-4366	201	242	member	member	NOUN
fnp-4366	201	243	of	of	ADP
fnp-4366	201	244	freie	freie	PROPN
fnp-4366	201	245	universität	universität	PROPN
fnp-4366	201	246	berlin	berlin	PROPN
fnp-4366	201	247	,	,	PUNCT
fnp-4366	201	248	charité	charité	PROPN
fnp-4366	201	249	,	,	PUNCT
fnp-4366	201	250	universitätsmedizin	universitätsmedizin	PROPN
fnp-4366	201	251	berlin	berlin	PROPN
fnp-4366	201	252	and	and	CCONJ
fnp-4366	201	253	humboldt	humboldt	PROPN
fnp-4366	201	254	-	-	PUNCT
fnp-4366	201	255	universität	universität	PROPN
fnp-4366	201	256	zu	zu	PROPN
fnp-4366	201	257	berlin	berlin	PROPN
fnp-4366	201	258	,	,	PUNCT
fnp-4366	201	259	berlin	berlin	PROPN
fnp-4366	201	260	,	,	PUNCT
fnp-4366	201	261	deutschland	deutschland	NOUN
fnp-4366	201	262	background	background	NOUN
fnp-4366	201	263	:	:	PUNCT
fnp-4366	201	264	pilocytic	pilocytic	ADJ
fnp-4366	201	265	astrocytomas	astrocytoma	NOUN
fnp-4366	201	266	(	(	PUNCT
fnp-4366	201	267	pa	pa	NOUN
fnp-4366	201	268	)	)	PUNCT
fnp-4366	201	269	are	be	AUX
fnp-4366	201	270	the	the	DET
fnp-4366	201	271	most	most	ADV
fnp-4366	201	272	common	common	ADJ
fnp-4366	201	273	primary	primary	ADJ
fnp-4366	201	274	central	central	ADJ
fnp-4366	201	275	nervous	nervous	ADJ
fnp-4366	201	276	system	system	NOUN
fnp-4366	201	277	neoplasms	neoplasm	NOUN
fnp-4366	201	278	in	in	ADP
fnp-4366	201	279	children	child	NOUN
fnp-4366	201	280	.	.	PUNCT
fnp-4366	202	1	the	the	DET
fnp-4366	202	2	vast	vast	ADJ
fnp-4366	202	3	majority	majority	NOUN
fnp-4366	202	4	of	of	ADP
fnp-4366	202	5	cases	case	NOUN
fnp-4366	202	6	harbor	harbor	VERB
fnp-4366	202	7	kiaa1549	kiaa1549	PROPN
fnp-4366	202	8	-	-	PUNCT
fnp-4366	202	9	braf	braf	NOUN
fnp-4366	202	10	fusions	fusion	NOUN
fnp-4366	202	11	and	and	CCONJ
fnp-4366	202	12	usually	usually	ADV
fnp-4366	202	13	go	go	VERB
fnp-4366	202	14	along	along	ADV
fnp-4366	202	15	with	with	ADP
fnp-4366	202	16	an	an	DET
fnp-4366	202	17	excellent	excellent	ADJ
fnp-4366	202	18	prognosis	prognosis	NOUN
fnp-4366	202	19	.	.	PUNCT
fnp-4366	203	1	in	in	ADP
fnp-4366	203	2	contrast	contrast	NOUN
fnp-4366	203	3	,	,	PUNCT
fnp-4366	203	4	pa	pa	PROPN
fnp-4366	203	5	in	in	ADP
fnp-4366	203	6	adult	adult	NOUN
fnp-4366	203	7	patients	patient	NOUN
fnp-4366	203	8	are	be	AUX
fnp-4366	203	9	rare	rare	ADJ
fnp-4366	203	10	,	,	PUNCT
fnp-4366	203	11	lack	lack	VERB
fnp-4366	203	12	kiaa1549	kiaa1549	PROPN
fnp-4366	203	13	-	-	PUNCT
fnp-4366	203	14	braf	braf	NOUN
fnp-4366	203	15	fusions	fusion	NOUN
fnp-4366	203	16	in	in	ADP
fnp-4366	203	17	many	many	ADJ
fnp-4366	203	18	cases	case	NOUN
fnp-4366	203	19	,	,	PUNCT
fnp-4366	203	20	and	and	CCONJ
fnp-4366	203	21	demonstrate	demonstrate	VERB
fnp-4366	203	22	a	a	DET
fnp-4366	203	23	more	more	ADV
fnp-4366	203	24	aggressive	aggressive	ADJ
fnp-4366	203	25	clinical	clinical	ADJ
fnp-4366	203	26	course	course	NOUN
fnp-4366	203	27	.	.	PUNCT
fnp-4366	204	1	purpose	purpose	NOUN
fnp-4366	204	2	:	:	PUNCT
fnp-4366	204	3	this	this	DET
fnp-4366	204	4	project	project	NOUN
fnp-4366	204	5	aims	aim	VERB
fnp-4366	204	6	at	at	ADP
fnp-4366	204	7	characterizing	characterize	VERB
fnp-4366	204	8	adult	adult	NOUN
fnp-4366	204	9	pa	pa	NOUN
fnp-4366	204	10	regarding	regard	VERB
fnp-4366	204	11	their	their	PRON
fnp-4366	204	12	molecular	molecular	ADJ
fnp-4366	204	13	profile	profile	NOUN
fnp-4366	204	14	and	and	CCONJ
fnp-4366	204	15	clinical	clinical	ADJ
fnp-4366	204	16	course	course	NOUN
fnp-4366	204	17	.	.	PUNCT
fnp-4366	205	1	methods	method	NOUN
fnp-4366	205	2	:	:	PUNCT
fnp-4366	205	3	we	we	PRON
fnp-4366	205	4	identified	identify	VERB
fnp-4366	205	5	55	55	NUM
fnp-4366	205	6	cases	case	NOUN
fnp-4366	205	7	with	with	ADP
fnp-4366	205	8	a	a	DET
fnp-4366	205	9	histological	histological	ADJ
fnp-4366	205	10	diagnosis	diagnosis	NOUN
fnp-4366	205	11	of	of	ADP
fnp-4366	205	12	pa	pa	PROPN
fnp-4366	205	13	in	in	ADP
fnp-4366	205	14	adulthood	adulthood	NOUN
fnp-4366	205	15	(	(	PUNCT
fnp-4366	205	16	≥18	≥18	NUM
fnp-4366	205	17	years	year	NOUN
fnp-4366	205	18	)	)	PUNCT
fnp-4366	205	19	.	.	PUNCT
fnp-4366	206	1	molecular	molecular	ADJ
fnp-4366	206	2	analyses	analysis	NOUN
fnp-4366	206	3	of	of	ADP
fnp-4366	206	4	these	these	DET
fnp-4366	206	5	cases	case	NOUN
fnp-4366	206	6	included	include	VERB
fnp-4366	206	7	dna	dna	PROPN
fnp-4366	206	8	methylation	methylation	NOUN
fnp-4366	206	9	analysis	analysis	NOUN
fnp-4366	206	10	,	,	PUNCT
fnp-4366	206	11	copy	copy	VERB
fnp-4366	206	12	number	number	NOUN
fnp-4366	206	13	profiling	profiling	NOUN
fnp-4366	206	14	,	,	PUNCT
fnp-4366	206	15	and	and	CCONJ
fnp-4366	206	16	dna	dna	NOUN
fnp-4366	206	17	sequencing	sequence	VERB
fnp-4366	206	18	for	for	ADP
fnp-4366	206	19	the	the	DET
fnp-4366	206	20	most	most	ADV
fnp-4366	206	21	common	common	ADJ
fnp-4366	206	22	mutations	mutation	NOUN
fnp-4366	206	23	in	in	ADP
fnp-4366	206	24	the	the	DET
fnp-4366	206	25	mapk	mapk	NOUN
fnp-4366	206	26	-	-	PUNCT
fnp-4366	206	27	pathway	pathway	NOUN
fnp-4366	206	28	.	.	PUNCT
fnp-4366	207	1	results	result	NOUN
fnp-4366	207	2	:	:	PUNCT
fnp-4366	207	3	the	the	DET
fnp-4366	207	4	mean	mean	ADJ
fnp-4366	207	5	age	age	NOUN
fnp-4366	207	6	of	of	ADP
fnp-4366	207	7	our	our	PRON
fnp-4366	207	8	cohort	cohort	NOUN
fnp-4366	207	9	was	be	AUX
fnp-4366	207	10	35	35	NUM
fnp-4366	207	11	years	year	NOUN
fnp-4366	207	12	.	.	PUNCT
fnp-4366	208	1	tumors	tumor	NOUN
fnp-4366	208	2	were	be	AUX
fnp-4366	208	3	located	locate	VERB
fnp-4366	208	4	infratentorially	infratentorially	ADV
fnp-4366	208	5	(	(	PUNCT
fnp-4366	208	6	41	41	NUM
fnp-4366	208	7	%	%	NOUN
fnp-4366	208	8	)	)	PUNCT
fnp-4366	208	9	,	,	PUNCT
fnp-4366	208	10	supratentorially	supratentorially	ADV
fnp-4366	208	11	(	(	PUNCT
fnp-4366	208	12	41	41	NUM
fnp-4366	208	13	%	%	NOUN
fnp-4366	208	14	)	)	PUNCT
fnp-4366	208	15	,	,	PUNCT
fnp-4366	208	16	and	and	CCONJ
fnp-4366	208	17	spinally	spinally	ADV
fnp-4366	208	18	(	(	PUNCT
fnp-4366	208	19	18	18	NUM
fnp-4366	208	20	%	%	NOUN
fnp-4366	208	21	)	)	PUNCT
fnp-4366	208	22	.	.	PUNCT
fnp-4366	209	1	after	after	ADP
fnp-4366	209	2	performing	perform	VERB
fnp-4366	209	3	global	global	ADJ
fnp-4366	209	4	dna	dna	PROPN
fnp-4366	209	5	methylation	methylation	NOUN
fnp-4366	209	6	analyses	analysis	NOUN
fnp-4366	209	7	and	and	CCONJ
fnp-4366	209	8	applying	apply	VERB
fnp-4366	209	9	the	the	DET
fnp-4366	209	10	dkfz	dkfz	ADJ
fnp-4366	209	11	brain	brain	NOUN
fnp-4366	209	12	tumor	tumor	NOUN
fnp-4366	209	13	classifier	classifier	NOUN
fnp-4366	209	14	(	(	PUNCT
fnp-4366	209	15	v12.5	v12.5	PROPN
fnp-4366	209	16	)	)	PUNCT
fnp-4366	209	17	,	,	PUNCT
fnp-4366	209	18	only	only	ADV
fnp-4366	209	19	25	25	NUM
fnp-4366	209	20	%	%	NOUN
fnp-4366	209	21	of	of	ADP
fnp-4366	209	22	these	these	DET
fnp-4366	209	23	cases	case	NOUN
fnp-4366	209	24	received	receive	VERB
fnp-4366	209	25	a	a	DET
fnp-4366	209	26	significant	significant	ADJ
fnp-4366	209	27	match	match	NOUN
fnp-4366	209	28	to	to	ADP
fnp-4366	209	29	one	one	NUM
fnp-4366	209	30	of	of	ADP
fnp-4366	209	31	the	the	DET
fnp-4366	209	32	reference	reference	NOUN
fnp-4366	209	33	methylation	methylation	NOUN
fnp-4366	209	34	classes	class	NOUN
fnp-4366	209	35	of	of	ADP
fnp-4366	209	36	pa	pa	PROPN
fnp-4366	209	37	(	(	PUNCT
fnp-4366	209	38	score	score	NOUN
fnp-4366	209	39	≥	≥	NOUN
fnp-4366	209	40	0.9	0.9	NUM
fnp-4366	209	41	)	)	PUNCT
fnp-4366	209	42	.	.	PUNCT
fnp-4366	210	1	20	20	NUM
fnp-4366	210	2	%	%	NOUN
fnp-4366	210	3	matched	match	VERB
fnp-4366	210	4	to	to	ADP
fnp-4366	210	5	different	different	ADJ
fnp-4366	210	6	entities	entity	NOUN
fnp-4366	210	7	,	,	PUNCT
fnp-4366	210	8	and	and	CCONJ
fnp-4366	210	9	55	55	NUM
fnp-4366	210	10	%	%	NOUN
fnp-4366	210	11	did	do	AUX
fnp-4366	210	12	not	not	PART
fnp-4366	210	13	match	match	VERB
fnp-4366	210	14	to	to	ADP
fnp-4366	210	15	any	any	DET
fnp-4366	210	16	brain	brain	NOUN
fnp-4366	210	17	tumor	tumor	NOUN
fnp-4366	210	18	class	class	NOUN
fnp-4366	210	19	.	.	PUNCT
fnp-4366	211	1	furthermore	furthermore	ADV
fnp-4366	211	2	,	,	PUNCT
fnp-4366	211	3	only	only	ADV
fnp-4366	211	4	23	23	NUM
fnp-4366	211	5	%	%	NOUN
fnp-4366	211	6	of	of	ADP
fnp-4366	211	7	the	the	DET
fnp-4366	211	8	tumors	tumor	NOUN
fnp-4366	211	9	exhibited	exhibit	VERB
fnp-4366	211	10	the	the	DET
fnp-4366	211	11	kiaa1549	kiaa1549	PROPN
fnp-4366	211	12	-	-	PUNCT
fnp-4366	211	13	braf	braf	NOUN
fnp-4366	211	14	fusion	fusion	NOUN
fnp-4366	211	15	.	.	PUNCT
fnp-4366	212	1	further	further	ADJ
fnp-4366	212	2	analyses	analysis	NOUN
fnp-4366	212	3	of	of	ADP
fnp-4366	212	4	tumors	tumor	NOUN
fnp-4366	212	5	with	with	ADP
fnp-4366	212	6	a	a	DET
fnp-4366	212	7	significant	significant	ADJ
fnp-4366	212	8	match	match	NOUN
fnp-4366	212	9	to	to	ADP
fnp-4366	212	10	one	one	NUM
fnp-4366	212	11	of	of	ADP
fnp-4366	212	12	the	the	DET
fnp-4366	212	13	three	three	NUM
fnp-4366	212	14	pa	pa	PROPN
fnp-4366	212	15	reference	reference	NOUN
fnp-4366	212	16	classes	class	NOUN
fnp-4366	212	17	showed	show	VERB
fnp-4366	212	18	that	that	SCONJ
fnp-4366	212	19	adult	adult	NOUN
fnp-4366	212	20	patients	patient	NOUN
fnp-4366	212	21	mostly	mostly	ADV
fnp-4366	212	22	had	have	VERB
fnp-4366	212	23	supratentorial	supratentorial	ADJ
fnp-4366	212	24	pa	pa	PROPN
fnp-4366	212	25	(	(	PUNCT
fnp-4366	212	26	lgg_pa_gg_st	lgg_pa_gg_st	PROPN
fnp-4366	212	27	,	,	PUNCT
fnp-4366	212	28	mean	mean	NOUN
fnp-4366	212	29	age	age	NOUN
fnp-4366	212	30	:	:	PUNCT
fnp-4366	212	31	20	20	NUM
fnp-4366	212	32	years	year	NOUN
fnp-4366	212	33	,	,	PUNCT
fnp-4366	212	34	n=45	n=45	NOUN
fnp-4366	212	35	)	)	PUNCT
fnp-4366	212	36	,	,	PUNCT
fnp-4366	212	37	while	while	SCONJ
fnp-4366	212	38	children	child	NOUN
fnp-4366	212	39	had	have	VERB
fnp-4366	212	40	pa	pa	PROPN
fnp-4366	212	41	in	in	ADP
fnp-4366	212	42	midline	midline	NOUN
fnp-4366	212	43	structures	structure	NOUN
fnp-4366	212	44	(	(	PUNCT
fnp-4366	212	45	lgg_pa_mid	lgg_pa_mid	PROPN
fnp-4366	212	46	,	,	PUNCT
fnp-4366	212	47	mean	mean	ADJ
fnp-4366	212	48	age	age	NOUN
fnp-4366	212	49	:	:	PUNCT
fnp-4366	212	50	9	9	NUM
fnp-4366	212	51	years	year	NOUN
fnp-4366	212	52	,	,	PUNCT
fnp-4366	212	53	n=51	n=51	NOUN
fnp-4366	212	54	)	)	PUNCT
fnp-4366	212	55	or	or	CCONJ
fnp-4366	212	56	in	in	ADP
fnp-4366	212	57	the	the	DET
fnp-4366	212	58	posterior	posterior	ADJ
fnp-4366	212	59	fossa	fossa	NOUN
fnp-4366	212	60	(	(	PUNCT
fnp-4366	212	61	lgg_pa_pf	lgg_pa_pf	PROPN
fnp-4366	212	62	,	,	PUNCT
fnp-4366	212	63	mean	mean	NOUN
fnp-4366	212	64	age	age	NOUN
fnp-4366	212	65	:	:	PUNCT
fnp-4366	212	66	11	11	NUM
fnp-4366	212	67	years	year	NOUN
fnp-4366	212	68	,	,	PUNCT
fnp-4366	212	69	n=159	n=159	NUM
fnp-4366	212	70	,	,	PUNCT
fnp-4366	212	71	p<0.005	p<0.005	NOUN
fnp-4366	212	72	)	)	PUNCT
fnp-4366	212	73	.	.	PUNCT
fnp-4366	213	1	among	among	ADP
fnp-4366	213	2	these	these	DET
fnp-4366	213	3	tumors	tumor	NOUN
fnp-4366	213	4	defined	define	VERB
fnp-4366	213	5	by	by	ADP
fnp-4366	213	6	dna	dna	PROPN
fnp-4366	213	7	methylation	methylation	NOUN
fnp-4366	213	8	,	,	PUNCT
fnp-4366	213	9	the	the	DET
fnp-4366	213	10	typical	typical	ADJ
fnp-4366	213	11	kiaa1549	kiaa1549	PROPN
fnp-4366	213	12	-	-	PUNCT
fnp-4366	213	13	braf	braf	NOUN
fnp-4366	213	14	fusion	fusion	NOUN
fnp-4366	213	15	was	be	AUX
fnp-4366	213	16	found	find	VERB
fnp-4366	213	17	in	in	ADP
fnp-4366	213	18	94	94	NUM
fnp-4366	213	19	%	%	NOUN
fnp-4366	213	20	of	of	ADP
fnp-4366	213	21	pediatric	pediatric	ADJ
fnp-4366	213	22	tumors	tumor	NOUN
fnp-4366	213	23	and	and	CCONJ
fnp-4366	213	24	only	only	ADV
fnp-4366	213	25	in	in	ADP
fnp-4366	213	26	45	45	NUM
fnp-4366	213	27	%	%	NOUN
fnp-4366	213	28	of	of	ADP
fnp-4366	213	29	tumors	tumor	NOUN
fnp-4366	213	30	occurring	occur	VERB
fnp-4366	213	31	in	in	ADP
fnp-4366	213	32	adults	adult	NOUN
fnp-4366	213	33	.	.	PUNCT
fnp-4366	214	1	conclusions	conclusion	NOUN
fnp-4366	214	2	:	:	PUNCT
fnp-4366	214	3	in	in	ADP
fnp-4366	214	4	summary	summary	NOUN
fnp-4366	214	5	,	,	PUNCT
fnp-4366	214	6	according	accord	VERB
fnp-4366	214	7	to	to	ADP
fnp-4366	214	8	dna	dna	PROPN
fnp-4366	214	9	methylation	methylation	NOUN
fnp-4366	214	10	profiling	profiling	NOUN
fnp-4366	214	11	,	,	PUNCT
fnp-4366	214	12	a	a	DET
fnp-4366	214	13	particularly	particularly	ADV
fnp-4366	214	14	high	high	ADJ
fnp-4366	214	15	fraction	fraction	NOUN
fnp-4366	214	16	of	of	ADP
fnp-4366	214	17	tumors	tumor	NOUN
fnp-4366	214	18	histologically	histologically	ADV
fnp-4366	214	19	appearing	appear	VERB
fnp-4366	214	20	as	as	SCONJ
fnp-4366	214	21	pa	pa	PROPN
fnp-4366	214	22	in	in	ADP
fnp-4366	214	23	adult	adult	NOUN
fnp-4366	214	24	patients	patient	NOUN
fnp-4366	214	25	do	do	AUX
fnp-4366	214	26	not	not	PART
fnp-4366	214	27	match	match	VERB
fnp-4366	214	28	known	known	ADJ
fnp-4366	214	29	reference	reference	NOUN
fnp-4366	214	30	cohorts	cohort	NOUN
fnp-4366	214	31	of	of	ADP
fnp-4366	214	32	pa	pa	PROPN
fnp-4366	214	33	.	.	PUNCT
fnp-4366	215	1	many	many	ADJ
fnp-4366	215	2	tumors	tumor	NOUN
fnp-4366	215	3	are	be	AUX
fnp-4366	215	4	even	even	ADV
fnp-4366	215	5	reflecting	reflect	VERB
fnp-4366	215	6	other	other	ADJ
fnp-4366	215	7	tumor	tumor	NOUN
fnp-4366	215	8	entities	entity	NOUN
fnp-4366	215	9	,	,	PUNCT
fnp-4366	215	10	indicating	indicate	VERB
fnp-4366	215	11	ambiguous	ambiguous	ADJ
fnp-4366	215	12	histological	histological	ADJ
fnp-4366	215	13	features	feature	NOUN
fnp-4366	215	14	.	.	PUNCT
fnp-4366	216	1	furthermore	furthermore	ADV
fnp-4366	216	2	,	,	PUNCT
fnp-4366	216	3	even	even	ADV
fnp-4366	216	4	in	in	ADP
fnp-4366	216	5	cases	case	NOUN
fnp-4366	216	6	that	that	PRON
fnp-4366	216	7	significantly	significantly	ADV
fnp-4366	216	8	match	match	VERB
fnp-4366	216	9	to	to	ADP
fnp-4366	216	10	pa	pa	PROPN
fnp-4366	216	11	regarding	regard	VERB
fnp-4366	216	12	dna	dna	PROPN
fnp-4366	216	13	methylation	methylation	NOUN
fnp-4366	216	14	,	,	PUNCT
fnp-4366	216	15	the	the	DET
fnp-4366	216	16	distribution	distribution	NOUN
fnp-4366	216	17	of	of	ADP
fnp-4366	216	18	genetic	genetic	ADJ
fnp-4366	216	19	drivers	driver	NOUN
fnp-4366	216	20	differs	differ	VERB
fnp-4366	216	21	from	from	ADP
fnp-4366	216	22	their	their	PRON
fnp-4366	216	23	pediatric	pediatric	ADJ
fnp-4366	216	24	counterparts	counterpart	NOUN
fnp-4366	216	25	.	.	PUNCT
fnp-4366	216	26	  	  	SPACE
fnp-4366	217	1	2.05	2.05	NUM
fnp-4366	217	2	free	free	ADJ
fnp-4366	217	3	neuropathol	neuropathol	NOUN
fnp-4366	217	4	3:20:25	3:20:25	NUM
fnp-4366	217	5	exploration	exploration	NOUN
fnp-4366	217	6	of	of	ADP
fnp-4366	217	7	cellular	cellular	ADJ
fnp-4366	217	8	origins	origin	NOUN
fnp-4366	217	9	and	and	CCONJ
fnp-4366	217	10	therapeutic	therapeutic	ADJ
fnp-4366	217	11	targets	target	NOUN
fnp-4366	217	12	by	by	ADP
fnp-4366	217	13	modeling	model	VERB
fnp-4366	217	14	high	high	ADJ
fnp-4366	217	15	grade	grade	NOUN
fnp-4366	217	16	pediatric	pediatric	ADJ
fnp-4366	217	17	glioma	glioma	NOUN
fnp-4366	217	18	of	of	ADP
fnp-4366	217	19	the	the	DET
fnp-4366	217	20	mycn	mycn	NOUN
fnp-4366	217	21	subclass	subclass	NOUN
fnp-4366	217	22	in	in	ADP
fnp-4366	217	23	mice	mouse	NOUN
fnp-4366	217	24	melanie	melanie	PROPN
fnp-4366	217	25	schoof1,2	schoof1,2	PROPN
fnp-4366	217	26	,	,	PUNCT
fnp-4366	217	27	shweta	shweta	PROPN
fnp-4366	217	28	godbole3	godbole3	PROPN
fnp-4366	217	29	,	,	PUNCT
fnp-4366	217	30	carolin	carolin	PROPN
fnp-4366	217	31	walter4,5	walter4,5	PROPN
fnp-4366	217	32	,	,	PUNCT
fnp-4366	217	33	matthias	matthias	PROPN
fnp-4366	217	34	dottermusch3,6	dottermusch3,6	PROPN
fnp-4366	217	35	,	,	PUNCT
fnp-4366	217	36	thomas	thomas	PROPN
fnp-4366	217	37	albert5	albert5	PROPN
fnp-4366	217	38	,	,	PUNCT
fnp-4366	217	39	annika	annika	PROPN
fnp-4366	217	40	ballast5	ballast5	PROPN
fnp-4366	217	41	,	,	PUNCT
fnp-4366	217	42	carolin	carolin	PROPN
fnp-4366	217	43	göbel1,2	göbel1,2	PROPN
fnp-4366	217	44	,	,	PUNCT
fnp-4366	217	45	sina	sina	PROPN
fnp-4366	217	46	neyazi1,2	neyazi1,2	PROPN
fnp-4366	217	47	,	,	PUNCT
fnp-4366	217	48	dörthe	dörthe	DET
fnp-4366	217	49	holdhof1,2	holdhof1,2	PROPN
fnp-4366	217	50	,	,	PUNCT
fnp-4366	217	51	catena	catena	PROPN
fnp-4366	217	52	kresbach1,6	kresbach1,6	PROPN
fnp-4366	217	53	,	,	PUNCT
fnp-4366	217	54	gefion	gefion	NOUN
fnp-4366	217	55	dorothea	dorothea	PROPN
fnp-4366	217	56	epplen1	epplen1	PROPN
fnp-4366	217	57	,	,	PUNCT
fnp-4366	217	58	mirjam	mirjam	PROPN
fnp-4366	217	59	blattner	blattner	NOUN
fnp-4366	217	60	-	-	PUNCT
fnp-4366	217	61	johnson7,8	johnson7,8	PROPN
fnp-4366	217	62	,	,	PUNCT
fnp-4366	217	63	franziska	franziska	PROPN
fnp-4366	217	64	modemann9,10	modemann9,10	PROPN
fnp-4366	217	65	,	,	PUNCT
fnp-4366	217	66	ann	ann	PROPN
fnp-4366	217	67	-	-	PUNCT
fnp-4366	217	68	kristin	kristin	PROPN
fnp-4366	217	69	afflerbach1,2	afflerbach1,2	PROPN
fnp-4366	217	70	,	,	PUNCT
fnp-4366	217	71	alicia	alicia	PROPN
fnp-4366	217	72	eckhardt1,11	eckhardt1,11	X
fnp-4366	217	73	,	,	PUNCT
fnp-4366	217	74	vanessa	vanessa	PROPN
fnp-4366	217	75	thaden1	thaden1	PROPN
fnp-4366	217	76	,	,	PUNCT
fnp-4366	217	77	nina	nina	PROPN
fnp-4366	217	78	struve11,12	struve11,12	PROPN
fnp-4366	217	79	,	,	PUNCT
fnp-4366	217	80	david	david	PROPN
fnp-4366	217	81	t.	t.	PROPN
fnp-4366	217	82	w.	w.	PROPN
fnp-4366	217	83	jones7,8	jones7,8	PROPN
fnp-4366	217	84	,	,	PUNCT
fnp-4366	217	85	kornelius	kornelius	PROPN
fnp-4366	217	86	kerl5	kerl5	PROPN
fnp-4366	217	87	,	,	PUNCT
fnp-4366	217	88	julia	julia	PROPN
fnp-4366	217	89	neumann3,6	neumann3,6	PROPN
fnp-4366	217	90	,	,	PUNCT
fnp-4366	217	91	ulrich	ulrich	PRON
fnp-4366	217	92	schüller1,2,6	schüller1,2,6	PROPN
fnp-4366	217	93	1	1	NUM
fnp-4366	217	94	research	research	NOUN
fnp-4366	217	95	institute	institute	NOUN
fnp-4366	217	96	children	child	NOUN
fnp-4366	217	97	’s	’s	PART
fnp-4366	217	98	cancer	cancer	NOUN
fnp-4366	217	99	center	center	PROPN
fnp-4366	217	100	hamburg	hamburg	PROPN
fnp-4366	217	101	,	,	PUNCT
fnp-4366	217	102	hamburg	hamburg	PROPN
fnp-4366	217	103	,	,	PUNCT
fnp-4366	217	104	germany	germany	PROPN
fnp-4366	217	105	2	2	NUM
fnp-4366	217	106	department	department	NOUN
fnp-4366	217	107	of	of	ADP
fnp-4366	217	108	pediatric	pediatric	ADJ
fnp-4366	217	109	hematology	hematology	NOUN
fnp-4366	217	110	and	and	CCONJ
fnp-4366	217	111	oncology	oncology	NOUN
fnp-4366	217	112	,	,	PUNCT
fnp-4366	217	113	university	university	NOUN
fnp-4366	217	114	medical	medical	ADJ
fnp-4366	217	115	center	center	PROPN
fnp-4366	217	116	hamburg	hamburg	PROPN
fnp-4366	217	117	-	-	PUNCT
fnp-4366	217	118	eppendorf	eppendorf	PROPN
fnp-4366	217	119	,	,	PUNCT
fnp-4366	217	120	hamburg	hamburg	PROPN
fnp-4366	217	121	,	,	PUNCT
fnp-4366	217	122	deutschland	deutschland	NOUN
fnp-4366	217	123	3	3	NUM
fnp-4366	217	124	center	center	NOUN
fnp-4366	217	125	for	for	ADP
fnp-4366	217	126	molecular	molecular	ADJ
fnp-4366	217	127	neurobiology	neurobiology	NOUN
fnp-4366	217	128	(	(	PUNCT
fnp-4366	217	129	zmnh	zmnh	NOUN
fnp-4366	217	130	)	)	PUNCT
fnp-4366	217	131	,	,	PUNCT
fnp-4366	217	132	university	university	NOUN
fnp-4366	217	133	medical	medical	ADJ
fnp-4366	217	134	center	center	PROPN
fnp-4366	217	135	hamburg	hamburg	PROPN
fnp-4366	217	136	-	-	PUNCT
fnp-4366	217	137	eppendorf	eppendorf	PROPN
fnp-4366	217	138	,	,	PUNCT
fnp-4366	217	139	hamburg	hamburg	PROPN
fnp-4366	217	140	,	,	PUNCT
fnp-4366	217	141	deutschland	deutschland	PROPN
fnp-4366	217	142	4	4	NUM
fnp-4366	217	143	institute	institute	NOUN
fnp-4366	217	144	of	of	ADP
fnp-4366	217	145	medical	medical	ADJ
fnp-4366	217	146	informatics	informatics	PROPN
fnp-4366	217	147	,	,	PUNCT
fnp-4366	217	148	university	university	NOUN
fnp-4366	217	149	of	of	ADP
fnp-4366	217	150	muenster	muenster	NOUN
fnp-4366	217	151	,	,	PUNCT
fnp-4366	217	152	muenster	muenster	NOUN
fnp-4366	217	153	,	,	PUNCT
fnp-4366	217	154	deutschland	deutschland	NOUN
fnp-4366	217	155	5	5	NUM
fnp-4366	217	156	department	department	NOUN
fnp-4366	217	157	of	of	ADP
fnp-4366	217	158	pediatric	pediatric	ADJ
fnp-4366	217	159	hematology	hematology	NOUN
fnp-4366	217	160	and	and	CCONJ
fnp-4366	217	161	oncology	oncology	NOUN
fnp-4366	217	162	,	,	PUNCT
fnp-4366	217	163	university	university	NOUN
fnp-4366	217	164	children	child	NOUN
fnp-4366	217	165	’s	’s	PART
fnp-4366	217	166	hospital	hospital	NOUN
fnp-4366	217	167	münster	münster	NOUN
fnp-4366	217	168	,	,	PUNCT
fnp-4366	217	169	muenster	muenster	NOUN
fnp-4366	217	170	,	,	PUNCT
fnp-4366	217	171	deutschland	deutschland	NOUN
fnp-4366	217	172	6	6	NUM
fnp-4366	217	173	institute	institute	NOUN
fnp-4366	217	174	of	of	ADP
fnp-4366	217	175	neuropathology	neuropathology	NOUN
fnp-4366	217	176	,	,	PUNCT
fnp-4366	217	177	university	university	NOUN
fnp-4366	217	178	medical	medical	ADJ
fnp-4366	217	179	center	center	PROPN
fnp-4366	217	180	hamburg	hamburg	PROPN
fnp-4366	217	181	-	-	PUNCT
fnp-4366	217	182	eppendorf	eppendorf	PROPN
fnp-4366	217	183	,	,	PUNCT
fnp-4366	217	184	hamburg	hamburg	PROPN
fnp-4366	217	185	,	,	PUNCT
fnp-4366	217	186	deutschland	deutschland	VERB
fnp-4366	217	187	7	7	NUM
fnp-4366	217	188	hopp	hopp	PROPN
fnp-4366	217	189	children	child	NOUN
fnp-4366	217	190	's	's	PART
fnp-4366	217	191	cancer	cancer	NOUN
fnp-4366	217	192	center	center	NOUN
fnp-4366	217	193	(	(	PUNCT
fnp-4366	217	194	kitz	kitz	PROPN
fnp-4366	217	195	)	)	PUNCT
fnp-4366	217	196	,	,	PUNCT
fnp-4366	217	197	heidelberg	heidelberg	PROPN
fnp-4366	217	198	,	,	PUNCT
fnp-4366	217	199	deutschland	deutschland	NOUN
fnp-4366	217	200	8	8	NUM
fnp-4366	217	201	pediatric	pediatric	ADJ
fnp-4366	217	202	glioma	glioma	NOUN
fnp-4366	217	203	research	research	NOUN
fnp-4366	217	204	group	group	NOUN
fnp-4366	217	205	,	,	PUNCT
fnp-4366	217	206	german	german	ADJ
fnp-4366	217	207	cancer	cancer	NOUN
fnp-4366	217	208	research	research	NOUN
fnp-4366	217	209	center	center	NOUN
fnp-4366	217	210	(	(	PUNCT
fnp-4366	217	211	dkfz	dkfz	PROPN
fnp-4366	217	212	)	)	PUNCT
fnp-4366	217	213	,	,	PUNCT
fnp-4366	217	214	heidelberg	heidelberg	NOUN
fnp-4366	217	215	,	,	PUNCT
fnp-4366	217	216	deutschland	deutschland	NOUN
fnp-4366	217	217	9	9	NUM
fnp-4366	217	218	department	department	NOUN
fnp-4366	217	219	of	of	ADP
fnp-4366	217	220	oncology	oncology	NOUN
fnp-4366	217	221	,	,	PUNCT
fnp-4366	217	222	hematology	hematology	NOUN
fnp-4366	217	223	and	and	CCONJ
fnp-4366	217	224	bone	bone	NOUN
fnp-4366	217	225	marrow	marrow	NOUN
fnp-4366	217	226	transplantation	transplantation	NOUN
fnp-4366	217	227	with	with	ADP
fnp-4366	217	228	division	division	NOUN
fnp-4366	217	229	of	of	ADP
fnp-4366	217	230	pneumology	pneumology	NOUN
fnp-4366	217	231	,	,	PUNCT
fnp-4366	217	232	university	university	NOUN
fnp-4366	217	233	medical	medical	ADJ
fnp-4366	217	234	center	center	PROPN
fnp-4366	217	235	hamburg	hamburg	PROPN
fnp-4366	217	236	-	-	PUNCT
fnp-4366	217	237	eppendorf	eppendorf	PROPN
fnp-4366	217	238	,	,	PUNCT
fnp-4366	217	239	hamburg	hamburg	PROPN
fnp-4366	217	240	,	,	PUNCT
fnp-4366	217	241	deutschland	deutschland	NOUN
fnp-4366	217	242	10	10	NUM
fnp-4366	217	243	mildred	mildred	PROPN
fnp-4366	217	244	scheel	scheel	PROPN
fnp-4366	217	245	cancer	cancer	NOUN
fnp-4366	217	246	career	career	NOUN
fnp-4366	217	247	center	center	NOUN
fnp-4366	217	248	,	,	PUNCT
fnp-4366	217	249	university	university	NOUN
fnp-4366	217	250	cancer	cancer	NOUN
fnp-4366	217	251	center	center	PROPN
fnp-4366	217	252	hamburg	hamburg	PROPN
fnp-4366	217	253	,	,	PUNCT
fnp-4366	217	254	university	university	NOUN
fnp-4366	217	255	medical	medical	ADJ
fnp-4366	217	256	center	center	PROPN
fnp-4366	217	257	hamburg	hamburg	PROPN
fnp-4366	217	258	-	-	PUNCT
fnp-4366	217	259	eppendorf	eppendorf	PROPN
fnp-4366	217	260	,	,	PUNCT
fnp-4366	217	261	hamburg	hamburg	PROPN
fnp-4366	217	262	,	,	PUNCT
fnp-4366	217	263	deutschland	deutschland	NOUN
fnp-4366	217	264	11	11	NUM
fnp-4366	217	265	department	department	NOUN
fnp-4366	217	266	of	of	ADP
fnp-4366	217	267	radiotherapy	radiotherapy	NOUN
fnp-4366	217	268	,	,	PUNCT
fnp-4366	217	269	university	university	NOUN
fnp-4366	217	270	medical	medical	ADJ
fnp-4366	217	271	center	center	PROPN
fnp-4366	217	272	hamburg	hamburg	PROPN
fnp-4366	217	273	-	-	PUNCT
fnp-4366	217	274	eppendorf	eppendorf	PROPN
fnp-4366	217	275	,	,	PUNCT
fnp-4366	217	276	hamburg	hamburg	PROPN
fnp-4366	217	277	,	,	PUNCT
fnp-4366	217	278	deutschland	deutschland	NOUN
fnp-4366	217	279	12	12	NUM
fnp-4366	217	280	mildred	mildred	PROPN
fnp-4366	217	281	scheel	scheel	PROPN
fnp-4366	217	282	cancer	cancer	NOUN
fnp-4366	217	283	career	career	NOUN
fnp-4366	217	284	center	center	NOUN
fnp-4366	217	285	hatrics4	hatrics4	NOUN
fnp-4366	217	286	,	,	PUNCT
fnp-4366	217	287	university	university	NOUN
fnp-4366	217	288	medical	medical	ADJ
fnp-4366	217	289	center	center	PROPN
fnp-4366	217	290	hamburg	hamburg	PROPN
fnp-4366	217	291	-	-	PUNCT
fnp-4366	217	292	eppendorf	eppendorf	PROPN
fnp-4366	217	293	,	,	PUNCT
fnp-4366	217	294	hamburg	hamburg	PROPN
fnp-4366	217	295	,	,	PUNCT
fnp-4366	217	296	deutschland	deutschland	NOUN
fnp-4366	217	297	pediatric	pediatric	ADJ
fnp-4366	217	298	gliomas	glioma	NOUN
fnp-4366	217	299	of	of	ADP
fnp-4366	217	300	the	the	DET
fnp-4366	217	301	mycn	mycn	NOUN
fnp-4366	217	302	subclass	subclass	NOUN
fnp-4366	217	303	,	,	PUNCT
fnp-4366	217	304	a	a	DET
fnp-4366	217	305	recently	recently	ADV
fnp-4366	217	306	described	describe	VERB
fnp-4366	217	307	highly	highly	ADV
fnp-4366	217	308	aggressive	aggressive	ADJ
fnp-4366	217	309	brain	brain	NOUN
fnp-4366	217	310	tumor	tumor	NOUN
fnp-4366	217	311	entity	entity	NOUN
fnp-4366	217	312	,	,	PUNCT
fnp-4366	217	313	frequently	frequently	ADV
fnp-4366	217	314	carry	carry	VERB
fnp-4366	217	315	amplifications	amplification	NOUN
fnp-4366	217	316	of	of	ADP
fnp-4366	217	317	mycn	mycn	NOUN
fnp-4366	217	318	and	and	CCONJ
fnp-4366	217	319	mutations	mutation	NOUN
fnp-4366	217	320	in	in	ADP
fnp-4366	217	321	tp53	tp53	PROPN
fnp-4366	217	322	.	.	PUNCT
fnp-4366	218	1	these	these	DET
fnp-4366	218	2	tumors	tumor	NOUN
fnp-4366	218	3	present	present	ADJ
fnp-4366	218	4	with	with	ADP
fnp-4366	218	5	a	a	DET
fnp-4366	218	6	median	median	ADJ
fnp-4366	218	7	age	age	NOUN
fnp-4366	218	8	of	of	ADP
fnp-4366	218	9	8	8	NUM
fnp-4366	218	10	years	year	NOUN
fnp-4366	218	11	and	and	CCONJ
fnp-4366	218	12	a	a	DET
fnp-4366	218	13	median	median	ADJ
fnp-4366	218	14	overall	overall	ADJ
fnp-4366	218	15	survival	survival	NOUN
fnp-4366	218	16	of	of	ADP
fnp-4366	218	17	only	only	ADV
fnp-4366	218	18	14	14	NUM
fnp-4366	218	19	months	month	NOUN
fnp-4366	218	20	.	.	PUNCT
fnp-4366	219	1	better	well	ADJ
fnp-4366	219	2	treatment	treatment	NOUN
fnp-4366	219	3	options	option	NOUN
fnp-4366	219	4	are	be	AUX
fnp-4366	219	5	urgently	urgently	ADV
fnp-4366	219	6	needed	need	VERB
fnp-4366	219	7	,	,	PUNCT
fnp-4366	219	8	as	as	SCONJ
fnp-4366	219	9	the	the	DET
fnp-4366	219	10	current	current	ADJ
fnp-4366	219	11	treatment	treatment	NOUN
fnp-4366	219	12	is	be	AUX
fnp-4366	219	13	ineffective	ineffective	ADJ
fnp-4366	219	14	and	and	CCONJ
fnp-4366	219	15	causes	cause	VERB
fnp-4366	219	16	severe	severe	ADJ
fnp-4366	219	17	side	side	NOUN
fnp-4366	219	18	effects	effect	NOUN
fnp-4366	219	19	.	.	PUNCT
fnp-4366	220	1	here	here	ADV
fnp-4366	220	2	,	,	PUNCT
fnp-4366	220	3	we	we	PRON
fnp-4366	220	4	describe	describe	VERB
fnp-4366	220	5	the	the	DET
fnp-4366	220	6	generation	generation	NOUN
fnp-4366	220	7	of	of	ADP
fnp-4366	220	8	a	a	DET
fnp-4366	220	9	novel	novel	ADJ
fnp-4366	220	10	mouse	mouse	NOUN
fnp-4366	220	11	model	model	NOUN
fnp-4366	220	12	,	,	PUNCT
fnp-4366	220	13	which	which	PRON
fnp-4366	220	14	can	can	AUX
fnp-4366	220	15	be	be	AUX
fnp-4366	220	16	used	use	VERB
fnp-4366	220	17	for	for	ADP
fnp-4366	220	18	preclinical	preclinical	ADJ
fnp-4366	220	19	research	research	NOUN
fnp-4366	220	20	.	.	PUNCT
fnp-4366	221	1	we	we	PRON
fnp-4366	221	2	bred	breed	VERB
fnp-4366	221	3	hgfap	hgfap	PROPN
fnp-4366	221	4	-	-	PUNCT
fnp-4366	221	5	cre::tp53fl	cre::tp53fl	PROPN
fnp-4366	221	6	/	/	SYM
fnp-4366	221	7	fl::lsl	fl::lsl	NOUN
fnp-4366	221	8	-	-	PUNCT
fnp-4366	221	9	mycn	mycn	NOUN
fnp-4366	221	10	mice	mouse	NOUN
fnp-4366	221	11	,	,	PUNCT
fnp-4366	221	12	which	which	PRON
fnp-4366	221	13	develop	develop	VERB
fnp-4366	221	14	large	large	ADJ
fnp-4366	221	15	forebrain	forebrain	NOUN
fnp-4366	221	16	tumors	tumor	NOUN
fnp-4366	221	17	with	with	ADP
fnp-4366	221	18	100	100	NUM
fnp-4366	221	19	%	%	NOUN
fnp-4366	221	20	penetrance	penetrance	NOUN
fnp-4366	221	21	within	within	ADP
fnp-4366	221	22	the	the	DET
fnp-4366	221	23	first	first	ADJ
fnp-4366	221	24	80	80	NUM
fnp-4366	221	25	days	day	NOUN
fnp-4366	221	26	of	of	ADP
fnp-4366	221	27	life	life	NOUN
fnp-4366	221	28	.	.	PUNCT
fnp-4366	222	1	the	the	DET
fnp-4366	222	2	murine	murine	ADJ
fnp-4366	222	3	tumors	tumor	NOUN
fnp-4366	222	4	show	show	VERB
fnp-4366	222	5	a	a	DET
fnp-4366	222	6	high	high	ADJ
fnp-4366	222	7	similarity	similarity	NOUN
fnp-4366	222	8	with	with	ADP
fnp-4366	222	9	human	human	ADJ
fnp-4366	222	10	tumors	tumor	NOUN
fnp-4366	222	11	in	in	ADP
fnp-4366	222	12	histology	histology	NOUN
fnp-4366	222	13	,	,	PUNCT
fnp-4366	222	14	gene	gene	NOUN
fnp-4366	222	15	expression	expression	NOUN
fnp-4366	222	16	,	,	PUNCT
fnp-4366	222	17	and	and	CCONJ
fnp-4366	222	18	global	global	ADJ
fnp-4366	222	19	dna	dna	PROPN
fnp-4366	222	20	methylation	methylation	NOUN
fnp-4366	222	21	pattern	pattern	NOUN
fnp-4366	222	22	.	.	PUNCT
fnp-4366	223	1	single	single	ADJ
fnp-4366	223	2	-	-	PUNCT
fnp-4366	223	3	cell	cell	NOUN
fnp-4366	223	4	gene	gene	NOUN
fnp-4366	223	5	expression	expression	NOUN
fnp-4366	223	6	analyzes	analyze	NOUN
fnp-4366	223	7	of	of	ADP
fnp-4366	223	8	these	these	DET
fnp-4366	223	9	tumors	tumor	NOUN
fnp-4366	223	10	revealed	reveal	VERB
fnp-4366	223	11	a	a	DET
fnp-4366	223	12	large	large	ADJ
fnp-4366	223	13	intratumoral	intratumoral	ADJ
fnp-4366	223	14	cell	cell	NOUN
fnp-4366	223	15	heterogeneity	heterogeneity	NOUN
fnp-4366	223	16	and	and	CCONJ
fnp-4366	223	17	,	,	PUNCT
fnp-4366	223	18	due	due	ADP
fnp-4366	223	19	to	to	ADP
fnp-4366	223	20	the	the	DET
fnp-4366	223	21	similarity	similarity	NOUN
fnp-4366	223	22	of	of	ADP
fnp-4366	223	23	the	the	DET
fnp-4366	223	24	tumor	tumor	NOUN
fnp-4366	223	25	cells	cell	NOUN
fnp-4366	223	26	with	with	ADP
fnp-4366	223	27	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	223	28	in	in	ADP
fnp-4366	223	29	different	different	ADJ
fnp-4366	223	30	developmental	developmental	ADJ
fnp-4366	223	31	stages	stage	NOUN
fnp-4366	223	32	,	,	PUNCT
fnp-4366	223	33	suggests	suggest	VERB
fnp-4366	223	34	a	a	DET
fnp-4366	223	35	glial	glial	ADJ
fnp-4366	223	36	origin	origin	NOUN
fnp-4366	223	37	of	of	ADP
fnp-4366	223	38	these	these	DET
fnp-4366	223	39	tumors	tumor	NOUN
fnp-4366	223	40	.	.	PUNCT
fnp-4366	224	1	additionally	additionally	ADV
fnp-4366	224	2	,	,	PUNCT
fnp-4366	224	3	we	we	PRON
fnp-4366	224	4	tested	test	VERB
fnp-4366	224	5	the	the	DET
fnp-4366	224	6	preclinical	preclinical	ADJ
fnp-4366	224	7	potential	potential	NOUN
fnp-4366	224	8	of	of	ADP
fnp-4366	224	9	our	our	PRON
fnp-4366	224	10	mouse	mouse	NOUN
fnp-4366	224	11	model	model	NOUN
fnp-4366	224	12	by	by	ADP
fnp-4366	224	13	showing	show	VERB
fnp-4366	224	14	sensitivity	sensitivity	NOUN
fnp-4366	224	15	of	of	ADP
fnp-4366	224	16	mouse	mouse	NOUN
fnp-4366	224	17	and	and	CCONJ
fnp-4366	224	18	human	human	ADJ
fnp-4366	224	19	tumor	tumor	NOUN
fnp-4366	224	20	cells	cell	NOUN
fnp-4366	224	21	to	to	PART
fnp-4366	224	22	aurka	aurka	VERB
fnp-4366	224	23	inhibition	inhibition	NOUN
fnp-4366	224	24	in	in	ADP
fnp-4366	224	25	vitro	vitro	NOUN
fnp-4366	224	26	.	.	PUNCT
fnp-4366	225	1	we	we	PRON
fnp-4366	225	2	believe	believe	VERB
fnp-4366	225	3	that	that	SCONJ
fnp-4366	225	4	further	further	ADJ
fnp-4366	225	5	characterization	characterization	NOUN
fnp-4366	225	6	and	and	CCONJ
fnp-4366	225	7	utilization	utilization	NOUN
fnp-4366	225	8	of	of	ADP
fnp-4366	225	9	the	the	DET
fnp-4366	225	10	model	model	NOUN
fnp-4366	225	11	will	will	AUX
fnp-4366	225	12	pave	pave	VERB
fnp-4366	225	13	the	the	DET
fnp-4366	225	14	way	way	NOUN
fnp-4366	225	15	to	to	ADP
fnp-4366	225	16	improved	improve	VERB
fnp-4366	225	17	treatment	treatment	NOUN
fnp-4366	225	18	strategies	strategy	NOUN
fnp-4366	225	19	for	for	ADP
fnp-4366	225	20	patients	patient	NOUN
fnp-4366	225	21	with	with	ADP
fnp-4366	225	22	these	these	DET
fnp-4366	225	23	highly	highly	ADV
fnp-4366	225	24	aggressive	aggressive	ADJ
fnp-4366	225	25	tumors	tumor	NOUN
fnp-4366	225	26	.	.	PUNCT
fnp-4366	225	27	  	  	SPACE
fnp-4366	226	1	2.06	2.06	NUM
fnp-4366	226	2	free	free	ADJ
fnp-4366	226	3	neuropathol	neuropathol	NOUN
fnp-4366	226	4	3:20:27	3:20:27	NUM
fnp-4366	226	5	the	the	DET
fnp-4366	226	6	genomic	genomic	NOUN
fnp-4366	226	7	and	and	CCONJ
fnp-4366	226	8	transcriptional	transcriptional	ADJ
fnp-4366	226	9	landscape	landscape	NOUN
fnp-4366	226	10	of	of	ADP
fnp-4366	226	11	primary	primary	ADJ
fnp-4366	226	12	central	central	ADJ
fnp-4366	226	13	nervous	nervous	ADJ
fnp-4366	226	14	system	system	NOUN
fnp-4366	226	15	lymphoma	lymphoma	NOUN
fnp-4366	226	16	josefine	josefine	PROPN
fnp-4366	226	17	radke1	radke1	PROPN
fnp-4366	226	18	,	,	PUNCT
fnp-4366	226	19	naveed	naveed	PROPN
fnp-4366	226	20	ishaque2	ishaque2	PROPN
fnp-4366	226	21	,	,	PUNCT
fnp-4366	226	22	reiner	reiner	NOUN
fnp-4366	226	23	siebert3	siebert3	PROPN
fnp-4366	226	24	,	,	PUNCT
fnp-4366	226	25	stefan	stefan	PROPN
fnp-4366	226	26	wiemann4	wiemann4	PROPN
fnp-4366	226	27	,	,	PUNCT
fnp-4366	226	28	frank	frank	PROPN
fnp-4366	226	29	heppner5	heppner5	PROPN
fnp-4366	226	30	1	1	NUM
fnp-4366	226	31	universität	universität	PROPN
fnp-4366	226	32	greifswald	greifswald	PROPN
fnp-4366	226	33	,	,	PUNCT
fnp-4366	226	34	pathologie	pathologie	PROPN
fnp-4366	226	35	,	,	PUNCT
fnp-4366	226	36	greifswald	greifswald	PROPN
fnp-4366	226	37	,	,	PUNCT
fnp-4366	226	38	deutschland	deutschland	PROPN
fnp-4366	226	39	2	2	NUM
fnp-4366	226	40	berlin	berlin	PROPN
fnp-4366	226	41	institute	institute	PROPN
fnp-4366	226	42	of	of	ADP
fnp-4366	226	43	health	health	PROPN
fnp-4366	226	44	(	(	PUNCT
fnp-4366	226	45	bih	bih	PROPN
fnp-4366	226	46	)	)	PUNCT
fnp-4366	226	47	,	,	PUNCT
fnp-4366	226	48	digital	digital	ADJ
fnp-4366	226	49	health	health	NOUN
fnp-4366	226	50	center	center	NOUN
fnp-4366	226	51	,	,	PUNCT
fnp-4366	226	52	berlin	berlin	PROPN
fnp-4366	226	53	,	,	PUNCT
fnp-4366	226	54	deutschland	deutschland	NOUN
fnp-4366	226	55	3	3	NUM
fnp-4366	226	56	ulm	ulm	PROPN
fnp-4366	226	57	university	university	PROPN
fnp-4366	226	58	&	&	CCONJ
fnp-4366	226	59	ulm	ulm	PROPN
fnp-4366	226	60	university	university	PROPN
fnp-4366	226	61	medical	medical	ADJ
fnp-4366	226	62	center	center	NOUN
fnp-4366	226	63	,	,	PUNCT
fnp-4366	226	64	human	human	ADJ
fnp-4366	226	65	genetics	genetic	NOUN
fnp-4366	226	66	,	,	PUNCT
fnp-4366	226	67	ulm	ulm	PROPN
fnp-4366	226	68	,	,	PUNCT
fnp-4366	226	69	deutschland	deutschland	NOUN
fnp-4366	226	70	4	4	NUM
fnp-4366	226	71	deutsches	deutsche	NOUN
fnp-4366	226	72	krebsforschungszentrum	krebsforschungszentrum	NOUN
fnp-4366	226	73	(	(	PUNCT
fnp-4366	226	74	dkfz	dkfz	PROPN
fnp-4366	226	75	)	)	PUNCT
fnp-4366	226	76	,	,	PUNCT
fnp-4366	226	77	heidelberg	heidelberg	NOUN
fnp-4366	226	78	,	,	PUNCT
fnp-4366	226	79	deutschland	deutschland	NOUN
fnp-4366	226	80	5	5	NUM
fnp-4366	226	81	charité	charité	ADJ
fnp-4366	226	82	,	,	PUNCT
fnp-4366	226	83	neuropathology	neuropathology	NOUN
fnp-4366	226	84	,	,	PUNCT
fnp-4366	226	85	berlin	berlin	PROPN
fnp-4366	226	86	,	,	PUNCT
fnp-4366	226	87	deutschland	deutschland	NOUN
fnp-4366	226	88	background	background	NOUN
fnp-4366	226	89	:	:	PUNCT
fnp-4366	226	90	primary	primary	ADJ
fnp-4366	226	91	lymphomas	lymphoma	NOUN
fnp-4366	226	92	of	of	ADP
fnp-4366	226	93	the	the	DET
fnp-4366	226	94	central	central	ADJ
fnp-4366	226	95	nervous	nervous	ADJ
fnp-4366	226	96	system	system	NOUN
fnp-4366	226	97	(	(	PUNCT
fnp-4366	226	98	pcnsl	pcnsl	NOUN
fnp-4366	226	99	)	)	PUNCT
fnp-4366	226	100	are	be	AUX
fnp-4366	226	101	mainly	mainly	ADV
fnp-4366	226	102	diffuse	diffuse	VERB
fnp-4366	226	103	large	large	ADJ
fnp-4366	226	104	b	b	NOUN
fnp-4366	226	105	-	-	PUNCT
fnp-4366	226	106	cell	cell	NOUN
fnp-4366	226	107	lymphomas	lymphoma	NOUN
fnp-4366	226	108	(	(	PUNCT
fnp-4366	226	109	dlbcls	dlbcls	NOUN
fnp-4366	226	110	)	)	PUNCT
fnp-4366	226	111	confined	confine	VERB
fnp-4366	226	112	to	to	ADP
fnp-4366	226	113	the	the	DET
fnp-4366	226	114	central	central	ADJ
fnp-4366	226	115	nervous	nervous	ADJ
fnp-4366	226	116	system	system	NOUN
fnp-4366	226	117	(	(	PUNCT
fnp-4366	226	118	cns	cns	NOUN
fnp-4366	226	119	)	)	PUNCT
fnp-4366	226	120	.	.	PUNCT
fnp-4366	227	1	despite	despite	SCONJ
fnp-4366	227	2	extensive	extensive	ADJ
fnp-4366	227	3	research	research	NOUN
fnp-4366	227	4	,	,	PUNCT
fnp-4366	227	5	the	the	DET
fnp-4366	227	6	molecular	molecular	ADJ
fnp-4366	227	7	alterations	alteration	NOUN
fnp-4366	227	8	leading	lead	VERB
fnp-4366	227	9	to	to	ADP
fnp-4366	227	10	pcnsl	pcnsl	NOUN
fnp-4366	227	11	have	have	AUX
fnp-4366	227	12	not	not	PART
fnp-4366	227	13	been	be	AUX
fnp-4366	227	14	fully	fully	ADV
fnp-4366	227	15	elucidated	elucidated	ADJ
fnp-4366	227	16	.	.	PUNCT
fnp-4366	228	1	aims	aim	VERB
fnp-4366	228	2	:	:	PUNCT
fnp-4366	228	3	in	in	ADP
fnp-4366	228	4	order	order	NOUN
fnp-4366	228	5	to	to	PART
fnp-4366	228	6	provide	provide	VERB
fnp-4366	228	7	a	a	DET
fnp-4366	228	8	comprehensive	comprehensive	ADJ
fnp-4366	228	9	description	description	NOUN
fnp-4366	228	10	of	of	ADP
fnp-4366	228	11	the	the	DET
fnp-4366	228	12	genomic	genomic	NOUN
fnp-4366	228	13	and	and	CCONJ
fnp-4366	228	14	transcriptional	transcriptional	ADJ
fnp-4366	228	15	landscape	landscape	NOUN
fnp-4366	228	16	of	of	ADP
fnp-4366	228	17	pcnsl	pcnsl	NOUN
fnp-4366	228	18	,	,	PUNCT
fnp-4366	228	19	we	we	PRON
fnp-4366	228	20	here	here	ADV
fnp-4366	228	21	performed	perform	VERB
fnp-4366	228	22	whole	whole	ADJ
fnp-4366	228	23	-	-	PUNCT
fnp-4366	228	24	genome	genome	NOUN
fnp-4366	228	25	and	and	CCONJ
fnp-4366	228	26	transcriptome	transcriptome	ADJ
fnp-4366	228	27	sequencing	sequence	VERB
fnp-4366	228	28	and	and	CCONJ
fnp-4366	228	29	integrative	integrative	ADJ
fnp-4366	228	30	analysis	analysis	NOUN
fnp-4366	228	31	of	of	ADP
fnp-4366	228	32	51	51	NUM
fnp-4366	228	33	lymphomas	lymphoma	NOUN
fnp-4366	228	34	presenting	present	VERB
fnp-4366	228	35	in	in	ADP
fnp-4366	228	36	the	the	DET
fnp-4366	228	37	cns	cns	NOUN
fnp-4366	228	38	,	,	PUNCT
fnp-4366	228	39	including	include	VERB
fnp-4366	228	40	42	42	NUM
fnp-4366	228	41	ebv	ebv	NOUN
fnp-4366	228	42	-	-	PUNCT
fnp-4366	228	43	negative	negative	ADJ
fnp-4366	228	44	pcnsl	pcnsl	NOUN
fnp-4366	228	45	,	,	PUNCT
fnp-4366	228	46	6	6	NUM
fnp-4366	228	47	secondary	secondary	ADJ
fnp-4366	228	48	cns	cns	NOUN
fnp-4366	228	49	lymphomas	lymphoma	NOUN
fnp-4366	228	50	(	(	PUNCT
fnp-4366	228	51	scnsl	scnsl	NOUN
fnp-4366	228	52	)	)	PUNCT
fnp-4366	228	53	and	and	CCONJ
fnp-4366	228	54	3	3	NUM
fnp-4366	228	55	ebv+	ebv+	NOUN
fnp-4366	228	56	cnsl	cnsl	NOUN
fnp-4366	228	57	and	and	CCONJ
fnp-4366	228	58	matched	match	VERB
fnp-4366	228	59	controls	control	NOUN
fnp-4366	228	60	.	.	PUNCT
fnp-4366	229	1	the	the	DET
fnp-4366	229	2	results	result	NOUN
fnp-4366	229	3	were	be	AUX
fnp-4366	229	4	compared	compare	VERB
fnp-4366	229	5	to	to	ADP
fnp-4366	229	6	an	an	DET
fnp-4366	229	7	independent	independent	ADJ
fnp-4366	229	8	validation	validation	NOUN
fnp-4366	229	9	cohort	cohort	NOUN
fnp-4366	229	10	of	of	ADP
fnp-4366	229	11	31	31	NUM
fnp-4366	229	12	ffpe	ffpe	NOUN
fnp-4366	229	13	cnsl	cnsl	NOUN
fnp-4366	229	14	specimens	specimen	NOUN
fnp-4366	229	15	(	(	PUNCT
fnp-4366	229	16	pcnsl	pcnsl	NOUN
fnp-4366	229	17	,	,	PUNCT
fnp-4366	229	18	n	n	NOUN
fnp-4366	229	19	=	=	SYM
fnp-4366	229	20	19	19	NUM
fnp-4366	229	21	;	;	PUNCT
fnp-4366	229	22	scnsl	scnsl	NOUN
fnp-4366	229	23	,	,	PUNCT
fnp-4366	229	24	n	n	NOUN
fnp-4366	229	25	=	=	SYM
fnp-4366	229	26	9	9	NUM
fnp-4366	229	27	;	;	PUNCT
fnp-4366	229	28	ebv+	ebv+	ADJ
fnp-4366	229	29	cnsl	cnsl	NOUN
fnp-4366	229	30	,	,	PUNCT
fnp-4366	229	31	n	n	NOUN
fnp-4366	229	32	=	=	SYM
fnp-4366	229	33	3	3	NUM
fnp-4366	229	34	)	)	PUNCT
fnp-4366	229	35	as	as	ADV
fnp-4366	229	36	well	well	ADV
fnp-4366	229	37	as	as	ADP
fnp-4366	229	38	39	39	NUM
fnp-4366	229	39	fl	fl	NOUN
fnp-4366	229	40	and	and	CCONJ
fnp-4366	229	41	36	36	NUM
fnp-4366	229	42	systemic	systemic	ADJ
fnp-4366	229	43	dlbcl	dlbcl	NOUN
fnp-4366	229	44	cases	case	NOUN
fnp-4366	229	45	outside	outside	ADP
fnp-4366	229	46	the	the	DET
fnp-4366	229	47	cns	cns	PROPN
fnp-4366	229	48	.	.	PUNCT
fnp-4366	230	1	results	result	NOUN
fnp-4366	230	2	:	:	PUNCT
fnp-4366	230	3	somatic	somatic	ADJ
fnp-4366	230	4	genomic	genomic	NOUN
fnp-4366	230	5	alterations	alteration	NOUN
fnp-4366	230	6	in	in	ADP
fnp-4366	230	7	pcnsl	pcnsl	NOUN
fnp-4366	230	8	mainly	mainly	ADV
fnp-4366	230	9	affect	affect	VERB
fnp-4366	230	10	the	the	DET
fnp-4366	230	11	jak	jak	PROPN
fnp-4366	230	12	-	-	PUNCT
fnp-4366	230	13	stat	stat	PROPN
fnp-4366	230	14	,	,	PUNCT
fnp-4366	230	15	nfkb	nfkb	PROPN
fnp-4366	230	16	,	,	PUNCT
fnp-4366	230	17	and	and	CCONJ
fnp-4366	230	18	b	b	X
fnp-4366	230	19	-	-	PUNCT
fnp-4366	230	20	cell	cell	NOUN
fnp-4366	230	21	receptor	receptor	NOUN
fnp-4366	230	22	signaling	signal	VERB
fnp-4366	230	23	pathways	pathway	NOUN
fnp-4366	230	24	,	,	PUNCT
fnp-4366	230	25	with	with	ADP
fnp-4366	230	26	hallmark	hallmark	ADJ
fnp-4366	230	27	recurrent	recurrent	ADJ
fnp-4366	230	28	mutations	mutation	NOUN
fnp-4366	230	29	including	include	VERB
fnp-4366	230	30	myd88	myd88	PROPN
fnp-4366	230	31	l265p	l265p	PROPN
fnp-4366	230	32	(	(	PUNCT
fnp-4366	230	33	67	67	NUM
fnp-4366	230	34	%	%	NOUN
fnp-4366	230	35	)	)	PUNCT
fnp-4366	230	36	and	and	CCONJ
fnp-4366	230	37	cd79b	cd79b	NOUN
fnp-4366	230	38	(	(	PUNCT
fnp-4366	230	39	63	63	NUM
fnp-4366	230	40	%	%	NOUN
fnp-4366	230	41	)	)	PUNCT
fnp-4366	230	42	,	,	PUNCT
fnp-4366	230	43	cdkn2a	cdkn2a	VERB
fnp-4366	230	44	deletions	deletion	NOUN
fnp-4366	230	45	(	(	PUNCT
fnp-4366	230	46	83	83	NUM
fnp-4366	230	47	%	%	NOUN
fnp-4366	230	48	)	)	PUNCT
fnp-4366	230	49	and	and	CCONJ
fnp-4366	230	50	also	also	ADV
fnp-4366	230	51	non	non	ADJ
fnp-4366	230	52	-	-	ADJ
fnp-4366	230	53	coding	code	VERB
fnp-4366	230	54	rna	rna	NOUN
fnp-4366	230	55	genes	gene	NOUN
fnp-4366	230	56	such	such	ADJ
fnp-4366	230	57	as	as	ADP
fnp-4366	230	58	malat1	malat1	NOUN
fnp-4366	230	59	(	(	PUNCT
fnp-4366	230	60	70	70	NUM
fnp-4366	230	61	%	%	NOUN
fnp-4366	230	62	)	)	PUNCT
fnp-4366	230	63	,	,	PUNCT
fnp-4366	230	64	neat	neat	ADJ
fnp-4366	230	65	(	(	PUNCT
fnp-4366	230	66	60	60	NUM
fnp-4366	230	67	%	%	NOUN
fnp-4366	230	68	)	)	PUNCT
fnp-4366	230	69	,	,	PUNCT
fnp-4366	230	70	and	and	CCONJ
fnp-4366	230	71	mir142	mir142	PROPN
fnp-4366	230	72	(	(	PUNCT
fnp-4366	230	73	80	80	NUM
fnp-4366	230	74	%	%	NOUN
fnp-4366	230	75	)	)	PUNCT
fnp-4366	230	76	.	.	PUNCT
fnp-4366	231	1	kataegis	kataegis	ADJ
fnp-4366	231	2	events	event	NOUN
fnp-4366	231	3	,	,	PUNCT
fnp-4366	231	4	which	which	PRON
fnp-4366	231	5	affected	affect	VERB
fnp-4366	231	6	15	15	NUM
fnp-4366	231	7	of	of	ADP
fnp-4366	231	8	50	50	NUM
fnp-4366	231	9	identified	identify	VERB
fnp-4366	231	10	driver	driver	NOUN
fnp-4366	231	11	genes	gene	NOUN
fnp-4366	231	12	and	and	CCONJ
fnp-4366	231	13	21	21	NUM
fnp-4366	231	14	of	of	ADP
fnp-4366	231	15	the	the	DET
fnp-4366	231	16	top	top	ADJ
fnp-4366	231	17	50	50	NUM
fnp-4366	231	18	mutated	mutate	VERB
fnp-4366	231	19	ncrnas	ncrna	NOUN
fnp-4366	231	20	,	,	PUNCT
fnp-4366	231	21	played	play	VERB
fnp-4366	231	22	a	a	DET
fnp-4366	231	23	decisive	decisive	ADJ
fnp-4366	231	24	role	role	NOUN
fnp-4366	231	25	in	in	ADP
fnp-4366	231	26	shaping	shape	VERB
fnp-4366	231	27	the	the	DET
fnp-4366	231	28	mutational	mutational	ADJ
fnp-4366	231	29	repertoire	repertoire	NOUN
fnp-4366	231	30	of	of	ADP
fnp-4366	231	31	pcnsl	pcnsl	NOUN
fnp-4366	231	32	.	.	PUNCT
fnp-4366	232	1	compared	compare	VERB
fnp-4366	232	2	to	to	ADP
fnp-4366	232	3	systemic	systemic	ADJ
fnp-4366	232	4	dlbcl	dlbcl	NOUN
fnp-4366	232	5	,	,	PUNCT
fnp-4366	232	6	pcnsls	pcnsls	NOUN
fnp-4366	232	7	exhibited	exhibit	VERB
fnp-4366	232	8	significantly	significantly	ADV
fnp-4366	232	9	more	more	ADV
fnp-4366	232	10	focal	focal	ADJ
fnp-4366	232	11	deletions	deletion	NOUN
fnp-4366	232	12	in	in	ADP
fnp-4366	232	13	6p21	6p21	NOUN
fnp-4366	232	14	targeting	target	VERB
fnp-4366	232	15	the	the	DET
fnp-4366	232	16	hla	hla	PROPN
fnp-4366	232	17	-	-	PUNCT
fnp-4366	232	18	d	d	NOUN
fnp-4366	232	19	locus	locus	NOUN
fnp-4366	232	20	that	that	PRON
fnp-4366	232	21	encodes	encode	NOUN
fnp-4366	232	22	for	for	ADP
fnp-4366	232	23	mhc	mhc	PROPN
fnp-4366	232	24	class	class	PROPN
fnp-4366	232	25	ii	ii	PROPN
fnp-4366	232	26	molecules	molecule	NOUN
fnp-4366	232	27	as	as	ADP
fnp-4366	232	28	a	a	DET
fnp-4366	232	29	potential	potential	ADJ
fnp-4366	232	30	mechanism	mechanism	NOUN
fnp-4366	232	31	of	of	ADP
fnp-4366	232	32	immune	immune	ADJ
fnp-4366	232	33	evasion	evasion	NOUN
fnp-4366	232	34	.	.	PUNCT
fnp-4366	233	1	mutational	mutational	ADJ
fnp-4366	233	2	signatures	signature	NOUN
fnp-4366	233	3	correlating	correlate	VERB
fnp-4366	233	4	with	with	ADP
fnp-4366	233	5	dna	dna	PROPN
fnp-4366	233	6	replication	replication	NOUN
fnp-4366	233	7	and	and	CCONJ
fnp-4366	233	8	mitosis	mitosis	NOUN
fnp-4366	233	9	(	(	PUNCT
fnp-4366	233	10	sbs1	sbs1	PROPN
fnp-4366	233	11	,	,	PUNCT
fnp-4366	233	12	id1	id1	PROPN
fnp-4366	233	13	and	and	CCONJ
fnp-4366	233	14	id2	id2	PROPN
fnp-4366	233	15	)	)	PUNCT
fnp-4366	233	16	were	be	AUX
fnp-4366	233	17	significantly	significantly	ADV
fnp-4366	233	18	enriched	enrich	VERB
fnp-4366	233	19	in	in	ADP
fnp-4366	233	20	pcnsl	pcnsl	NOUN
fnp-4366	233	21	(	(	PUNCT
fnp-4366	233	22	sbs1	sbs1	NOUN
fnp-4366	233	23	:	:	PUNCT
fnp-4366	233	24	p	p	PROPN
fnp-4366	233	25	=	=	PROPN
fnp-4366	233	26	0.0027	0.0027	NUM
fnp-4366	233	27	,	,	PUNCT
fnp-4366	233	28	id1	id1	PROPN
fnp-4366	233	29	/	/	SYM
fnp-4366	233	30	id2	id2	PROPN
fnp-4366	233	31	:	:	PUNCT
fnp-4366	233	32	p	p	X
fnp-4366	233	33	<	<	X
fnp-4366	233	34	1x10	1x10	NUM
fnp-4366	233	35	-	-	SYM
fnp-4366	233	36	4	4	NUM
fnp-4366	233	37	)	)	PUNCT
fnp-4366	233	38	.	.	PUNCT
fnp-4366	234	1	furthermore	furthermore	ADV
fnp-4366	234	2	,	,	PUNCT
fnp-4366	234	3	tert	tert	NOUN
fnp-4366	234	4	gene	gene	NOUN
fnp-4366	234	5	expression	expression	NOUN
fnp-4366	234	6	was	be	AUX
fnp-4366	234	7	significantly	significantly	ADV
fnp-4366	234	8	higher	high	ADJ
fnp-4366	234	9	in	in	ADP
fnp-4366	234	10	pcnsl	pcnsl	NOUN
fnp-4366	234	11	compared	compare	VERB
fnp-4366	234	12	to	to	ADP
fnp-4366	234	13	abc	abc	PROPN
fnp-4366	234	14	-	-	PUNCT
fnp-4366	234	15	dlbcl	dlbcl	NOUN
fnp-4366	234	16	(	(	PUNCT
fnp-4366	234	17	p	p	X
fnp-4366	234	18	=	=	NOUN
fnp-4366	234	19	0.027	0.027	NUM
fnp-4366	234	20	)	)	PUNCT
fnp-4366	234	21	.	.	PUNCT
fnp-4366	235	1	although	although	SCONJ
fnp-4366	235	2	pcnsl	pcnsl	NOUN
fnp-4366	235	3	share	share	VERB
fnp-4366	235	4	many	many	ADJ
fnp-4366	235	5	genetic	genetic	ADJ
fnp-4366	235	6	alterations	alteration	NOUN
fnp-4366	235	7	with	with	ADP
fnp-4366	235	8	systemic	systemic	ADJ
fnp-4366	235	9	abc	abc	NOUN
fnp-4366	235	10	-	-	PUNCT
fnp-4366	235	11	dlbcl	dlbcl	NOUN
fnp-4366	235	12	in	in	ADP
fnp-4366	235	13	the	the	DET
fnp-4366	235	14	same	same	ADJ
fnp-4366	235	15	signaling	signal	VERB
fnp-4366	235	16	pathways	pathway	NOUN
fnp-4366	235	17	,	,	PUNCT
fnp-4366	235	18	transcriptome	transcriptome	ADJ
fnp-4366	235	19	analysis	analysis	NOUN
fnp-4366	235	20	clearly	clearly	ADV
fnp-4366	235	21	distinguished	distinguish	VERB
fnp-4366	235	22	both	both	CCONJ
fnp-4366	235	23	into	into	ADP
fnp-4366	235	24	distinct	distinct	ADJ
fnp-4366	235	25	molecular	molecular	ADJ
fnp-4366	235	26	subtypes	subtype	NOUN
fnp-4366	235	27	.	.	PUNCT
fnp-4366	236	1	ebv+	ebv+	ADJ
fnp-4366	236	2	cnsl	cnsl	NOUN
fnp-4366	236	3	cases	case	NOUN
fnp-4366	236	4	may	may	AUX
fnp-4366	236	5	be	be	AUX
fnp-4366	236	6	distinguished	distinguish	VERB
fnp-4366	236	7	by	by	ADP
fnp-4366	236	8	lack	lack	NOUN
fnp-4366	236	9	of	of	ADP
fnp-4366	236	10	recurrent	recurrent	ADJ
fnp-4366	236	11	mutational	mutational	ADJ
fnp-4366	236	12	hotspots	hotspot	NOUN
fnp-4366	236	13	apart	apart	ADV
fnp-4366	236	14	from	from	ADP
fnp-4366	236	15	ig	ig	PROPN
fnp-4366	236	16	and	and	CCONJ
fnp-4366	236	17	hla	hla	PROPN
fnp-4366	236	18	-	-	PUNCT
fnp-4366	236	19	drb	drb	PROPN
fnp-4366	236	20	loci	loci	NOUN
fnp-4366	236	21	.	.	PUNCT
fnp-4366	237	1	conclusion	conclusion	NOUN
fnp-4366	237	2	:	:	PUNCT
fnp-4366	237	3	we	we	PRON
fnp-4366	237	4	show	show	VERB
fnp-4366	237	5	that	that	SCONJ
fnp-4366	237	6	pcnsl	pcnsl	NOUN
fnp-4366	237	7	can	can	AUX
fnp-4366	237	8	be	be	AUX
fnp-4366	237	9	clearly	clearly	ADV
fnp-4366	237	10	distinguished	distinguish	VERB
fnp-4366	237	11	from	from	ADP
fnp-4366	237	12	dlbcl	dlbcl	NOUN
fnp-4366	237	13	,	,	PUNCT
fnp-4366	237	14	having	have	VERB
fnp-4366	237	15	distinct	distinct	ADJ
fnp-4366	237	16	expression	expression	NOUN
fnp-4366	237	17	profiles	profile	NOUN
fnp-4366	237	18	,	,	PUNCT
fnp-4366	237	19	ig	ig	PROPN
fnp-4366	237	20	expression	expression	NOUN
fnp-4366	237	21	and	and	CCONJ
fnp-4366	237	22	translocation	translocation	NOUN
fnp-4366	237	23	patterns	pattern	NOUN
fnp-4366	237	24	,	,	PUNCT
fnp-4366	237	25	as	as	ADV
fnp-4366	237	26	well	well	ADV
fnp-4366	237	27	as	as	ADP
fnp-4366	237	28	specific	specific	ADJ
fnp-4366	237	29	combinations	combination	NOUN
fnp-4366	237	30	of	of	ADP
fnp-4366	237	31	genetic	genetic	ADJ
fnp-4366	237	32	alterations	alteration	NOUN
fnp-4366	237	33	.	.	PUNCT
fnp-4366	237	34	  	  	SPACE
fnp-4366	238	1	2.07	2.07	NUM
fnp-4366	238	2	free	free	ADJ
fnp-4366	238	3	neuropathol	neuropathol	NOUN
fnp-4366	238	4	3:20:28	3:20:28	NUM
fnp-4366	238	5	molecular	molecular	ADJ
fnp-4366	238	6	mechanisms	mechanism	NOUN
fnp-4366	238	7	of	of	ADP
fnp-4366	238	8	therapy	therapy	NOUN
fnp-4366	238	9	resistance	resistance	NOUN
fnp-4366	238	10	in	in	ADP
fnp-4366	238	11	malignant	malignant	ADJ
fnp-4366	238	12	melanoma	melanoma	NOUN
fnp-4366	238	13	brain	brain	NOUN
fnp-4366	238	14	metastasis	metastasis	NOUN
fnp-4366	238	15	elisa	elisa	NOUN
fnp-4366	238	16	schumann1	schumann1	PROPN
fnp-4366	238	17	,	,	PUNCT
fnp-4366	238	18	randi	randi	PROPN
fnp-4366	238	19	koll2	koll2	PROPN
fnp-4366	238	20	,	,	PUNCT
fnp-4366	238	21	julia	julia	PROPN
fnp-4366	238	22	onken2	onken2	PROPN
fnp-4366	238	23	,	,	PUNCT
fnp-4366	238	24	karsten	karsten	PROPN
fnp-4366	238	25	jürchott2	jürchott2	PROPN
fnp-4366	238	26	,	,	PUNCT
fnp-4366	238	27	torben	torben	PROPN
fnp-4366	238	28	redmer3	redmer3	PROPN
fnp-4366	238	29	,	,	PUNCT
fnp-4366	238	30	josefine	josefine	PROPN
fnp-4366	238	31	radke4	radke4	PROPN
fnp-4366	238	32	1	1	NUM
fnp-4366	238	33	charité	charité	PROPN
fnp-4366	238	34	universitätsmedizin	universitätsmedizin	PROPN
fnp-4366	238	35	berlin	berlin	PROPN
fnp-4366	238	36	,	,	PUNCT
fnp-4366	238	37	institut	institut	PROPN
fnp-4366	238	38	für	für	PROPN
fnp-4366	238	39	neuropathologie	neuropathologie	PROPN
fnp-4366	238	40	,	,	PUNCT
fnp-4366	238	41	berlin	berlin	PROPN
fnp-4366	238	42	,	,	PUNCT
fnp-4366	238	43	deutschland	deutschland	NOUN
fnp-4366	238	44	2	2	NUM
fnp-4366	238	45	charité	charité	PROPN
fnp-4366	238	46	universitätsmedizin	universitätsmedizin	PROPN
fnp-4366	238	47	berlin	berlin	PROPN
fnp-4366	238	48	,	,	PUNCT
fnp-4366	238	49	berlin	berlin	PROPN
fnp-4366	238	50	,	,	PUNCT
fnp-4366	238	51	deutschland	deutschland	NOUN
fnp-4366	238	52	3	3	NUM
fnp-4366	238	53	veterinärmedizinische	veterinärmedizinische	PROPN
fnp-4366	238	54	universität	universität	PROPN
fnp-4366	238	55	wien	wien	PROPN
fnp-4366	238	56	,	,	PUNCT
fnp-4366	238	57	wien	wien	PROPN
fnp-4366	238	58	,	,	PUNCT
fnp-4366	238	59	austria	austria	PROPN
fnp-4366	238	60	4	4	NUM
fnp-4366	238	61	universität	universität	PROPN
fnp-4366	238	62	greifswald	greifswald	NOUN
fnp-4366	238	63	,	,	PUNCT
fnp-4366	238	64	greifswald	greifswald	PROPN
fnp-4366	238	65	,	,	PUNCT
fnp-4366	238	66	deutschland	deutschland	NOUN
fnp-4366	238	67	background	background	NOUN
fnp-4366	238	68	:	:	PUNCT
fnp-4366	238	69	malignant	malignant	ADJ
fnp-4366	238	70	melanoma	melanoma	NOUN
fnp-4366	238	71	(	(	PUNCT
fnp-4366	238	72	mm	mm	NOUN
fnp-4366	238	73	)	)	PUNCT
fnp-4366	238	74	is	be	AUX
fnp-4366	238	75	among	among	ADP
fnp-4366	238	76	the	the	DET
fnp-4366	238	77	tumor	tumor	NOUN
fnp-4366	238	78	entities	entity	NOUN
fnp-4366	238	79	with	with	ADP
fnp-4366	238	80	the	the	DET
fnp-4366	238	81	highest	high	ADJ
fnp-4366	238	82	potential	potential	NOUN
fnp-4366	238	83	to	to	PART
fnp-4366	238	84	spread	spread	VERB
fnp-4366	238	85	to	to	ADP
fnp-4366	238	86	the	the	DET
fnp-4366	238	87	cns	cns	NOUN
fnp-4366	238	88	.	.	PUNCT
fnp-4366	239	1	about	about	ADV
fnp-4366	239	2	45	45	NUM
fnp-4366	239	3	%	%	NOUN
fnp-4366	239	4	of	of	ADP
fnp-4366	239	5	mm	mm	PROPN
fnp-4366	239	6	patients	patient	NOUN
fnp-4366	239	7	suffer	suffer	VERB
fnp-4366	239	8	from	from	ADP
fnp-4366	239	9	brain	brain	NOUN
fnp-4366	239	10	metastasis	metastasis	NOUN
fnp-4366	239	11	likely	likely	ADV
fnp-4366	239	12	proceeding	proceed	VERB
fnp-4366	239	13	continuously	continuously	ADV
fnp-4366	239	14	during	during	ADP
fnp-4366	239	15	the	the	DET
fnp-4366	239	16	course	course	NOUN
fnp-4366	239	17	of	of	ADP
fnp-4366	239	18	disease	disease	NOUN
fnp-4366	239	19	.	.	PUNCT
fnp-4366	240	1	genetically	genetically	ADV
fnp-4366	240	2	and	and	CCONJ
fnp-4366	240	3	molecularly	molecularly	ADV
fnp-4366	240	4	distinct	distinct	ADJ
fnp-4366	240	5	subclones	subclone	NOUN
fnp-4366	240	6	lead	lead	VERB
fnp-4366	240	7	to	to	ADP
fnp-4366	240	8	tumor	tumor	NOUN
fnp-4366	240	9	heterogeneity	heterogeneity	NOUN
fnp-4366	240	10	which	which	PRON
fnp-4366	240	11	is	be	AUX
fnp-4366	240	12	followed	follow	VERB
fnp-4366	240	13	by	by	ADP
fnp-4366	240	14	therapy	therapy	NOUN
fnp-4366	240	15	resistance	resistance	NOUN
fnp-4366	240	16	and	and	CCONJ
fnp-4366	240	17	poor	poor	ADJ
fnp-4366	240	18	prognosis	prognosis	NOUN
fnp-4366	240	19	.	.	PUNCT
fnp-4366	241	1	previous	previous	ADJ
fnp-4366	241	2	studies	study	NOUN
fnp-4366	241	3	suggested	suggest	VERB
fnp-4366	241	4	increased	increase	VERB
fnp-4366	241	5	metastatic	metastatic	ADJ
fnp-4366	241	6	potential	potential	NOUN
fnp-4366	241	7	to	to	ADP
fnp-4366	241	8	and	and	CCONJ
fnp-4366	241	9	within	within	ADP
fnp-4366	241	10	the	the	DET
fnp-4366	241	11	brain	brain	NOUN
fnp-4366	241	12	under	under	ADP
fnp-4366	241	13	braf	braf	NOUN
fnp-4366	241	14	inhibitor	inhibitor	NOUN
fnp-4366	241	15	(	(	PUNCT
fnp-4366	241	16	brafi	brafi	PROPN
fnp-4366	241	17	)	)	PUNCT
fnp-4366	241	18	therapy	therapy	NOUN
fnp-4366	241	19	,	,	PUNCT
fnp-4366	241	20	which	which	PRON
fnp-4366	241	21	is	be	AUX
fnp-4366	241	22	caused	cause	VERB
fnp-4366	241	23	by	by	ADP
fnp-4366	241	24	upregulation	upregulation	NOUN
fnp-4366	241	25	of	of	ADP
fnp-4366	241	26	a	a	DET
fnp-4366	241	27	subset	subset	NOUN
fnp-4366	241	28	of	of	ADP
fnp-4366	241	29	molecular	molecular	ADJ
fnp-4366	241	30	drivers	driver	NOUN
fnp-4366	241	31	controlling	control	VERB
fnp-4366	241	32	migratory	migratory	NOUN
fnp-4366	241	33	and	and	CCONJ
fnp-4366	241	34	invasion	invasion	NOUN
fnp-4366	241	35	such	such	ADJ
fnp-4366	241	36	as	as	ADP
fnp-4366	241	37	the	the	DET
fnp-4366	241	38	nerve	nerve	NOUN
fnp-4366	241	39	growth	growth	NOUN
fnp-4366	241	40	factor	factor	NOUN
fnp-4366	241	41	receptor	receptor	NOUN
fnp-4366	241	42	cd271	cd271	NOUN
fnp-4366	241	43	/	/	SYM
fnp-4366	241	44	ngfr	ngfr	NOUN
fnp-4366	241	45	.	.	PUNCT
fnp-4366	242	1	aims	aim	VERB
fnp-4366	242	2	:	:	PUNCT
fnp-4366	242	3	to	to	PART
fnp-4366	242	4	gain	gain	VERB
fnp-4366	242	5	insight	insight	NOUN
fnp-4366	242	6	into	into	ADP
fnp-4366	242	7	the	the	DET
fnp-4366	242	8	molecular	molecular	ADJ
fnp-4366	242	9	features	feature	NOUN
fnp-4366	242	10	of	of	ADP
fnp-4366	242	11	migration	migration	NOUN
fnp-4366	242	12	and	and	CCONJ
fnp-4366	242	13	invasion	invasion	NOUN
fnp-4366	242	14	of	of	ADP
fnp-4366	242	15	patient	patient	ADJ
fnp-4366	242	16	derived	derive	VERB
fnp-4366	242	17	cell	cell	NOUN
fnp-4366	242	18	lines	line	NOUN
fnp-4366	242	19	from	from	ADP
fnp-4366	242	20	mm	mm	NUM
fnp-4366	242	21	brain	brain	NOUN
fnp-4366	242	22	metastases	metastasis	NOUN
fnp-4366	242	23	(	(	PUNCT
fnp-4366	242	24	bm	bm	PROPN
fnp-4366	242	25	)	)	PUNCT
fnp-4366	242	26	that	that	PRON
fnp-4366	242	27	were	be	AUX
fnp-4366	242	28	therapy	therapy	NOUN
fnp-4366	242	29	-	-	PUNCT
fnp-4366	242	30	responsive	responsive	ADJ
fnp-4366	242	31	or	or	CCONJ
fnp-4366	242	32	therapy	therapy	NOUN
fnp-4366	242	33	-	-	PUNCT
fnp-4366	242	34	resistant	resistant	ADJ
fnp-4366	242	35	to	to	ADP
fnp-4366	242	36	brafi	brafi	PROPN
fnp-4366	242	37	,	,	PUNCT
fnp-4366	242	38	radiotherapy	radiotherapy	NOUN
fnp-4366	242	39	and	and	CCONJ
fnp-4366	242	40	immune	immune	ADJ
fnp-4366	242	41	checkpoint	checkpoint	NOUN
fnp-4366	242	42	inhibitors	inhibitor	NOUN
fnp-4366	242	43	.	.	PUNCT
fnp-4366	243	1	methods	method	NOUN
fnp-4366	243	2	:	:	PUNCT
fnp-4366	243	3	we	we	PRON
fnp-4366	243	4	generated	generate	VERB
fnp-4366	243	5	patient	patient	ADJ
fnp-4366	243	6	derived	derive	VERB
fnp-4366	243	7	cell	cell	NOUN
fnp-4366	243	8	lines	line	NOUN
fnp-4366	243	9	from	from	ADP
fnp-4366	243	10	mm	mm	PROPN
fnp-4366	243	11	bm	bm	PROPN
fnp-4366	243	12	(	(	PUNCT
fnp-4366	243	13	n	n	NOUN
fnp-4366	243	14	=	=	NUM
fnp-4366	243	15	9	9	NUM
fnp-4366	243	16	)	)	PUNCT
fnp-4366	243	17	and	and	CCONJ
fnp-4366	243	18	performed	perform	VERB
fnp-4366	243	19	dna	dna	NOUN
fnp-4366	243	20	-	-	PUNCT
fnp-4366	243	21	sequencing	sequence	VERB
fnp-4366	243	22	(	(	PUNCT
fnp-4366	243	23	n	n	NOUN
fnp-4366	243	24	=	=	SYM
fnp-4366	243	25	5	5	NUM
fnp-4366	243	26	)	)	PUNCT
fnp-4366	243	27	and	and	CCONJ
fnp-4366	243	28	transcriptome	transcriptome	ADJ
fnp-4366	243	29	analyses	analysis	NOUN
fnp-4366	243	30	(	(	PUNCT
fnp-4366	243	31	n	n	NOUN
fnp-4366	243	32	=	=	SYM
fnp-4366	243	33	2	2	NUM
fnp-4366	243	34	)	)	PUNCT
fnp-4366	243	35	of	of	ADP
fnp-4366	243	36	cell	cell	NOUN
fnp-4366	243	37	lines	line	NOUN
fnp-4366	243	38	and	and	CCONJ
fnp-4366	243	39	concordant	concordant	ADJ
fnp-4366	243	40	tumors	tumor	NOUN
fnp-4366	243	41	(	(	PUNCT
fnp-4366	243	42	n	n	NOUN
fnp-4366	243	43	=	=	SYM
fnp-4366	243	44	2	2	NUM
fnp-4366	243	45	)	)	PUNCT
fnp-4366	243	46	.	.	PUNCT
fnp-4366	244	1	furthermore	furthermore	ADV
fnp-4366	244	2	,	,	PUNCT
fnp-4366	244	3	we	we	PRON
fnp-4366	244	4	used	use	VERB
fnp-4366	244	5	the	the	DET
fnp-4366	244	6	incucyte	incucyte	ADJ
fnp-4366	244	7	®	®	NOUN
fnp-4366	244	8	live	live	ADJ
fnp-4366	244	9	-	-	PUNCT
fnp-4366	244	10	cell	cell	NOUN
fnp-4366	244	11	analysis	analysis	NOUN
fnp-4366	244	12	to	to	PART
fnp-4366	244	13	perform	perform	VERB
fnp-4366	244	14	high	high	ADJ
fnp-4366	244	15	throughput	throughput	NOUN
fnp-4366	244	16	scratch	scratch	NOUN
fnp-4366	244	17	wound	wound	NOUN
fnp-4366	244	18	assays	assay	NOUN
fnp-4366	244	19	with	with	ADP
fnp-4366	244	20	patient	patient	ADJ
fnp-4366	244	21	derived	derive	VERB
fnp-4366	244	22	cell	cell	NOUN
fnp-4366	244	23	lines	line	NOUN
fnp-4366	244	24	,	,	PUNCT
fnp-4366	244	25	which	which	PRON
fnp-4366	244	26	were	be	AUX
fnp-4366	244	27	genetically	genetically	ADV
fnp-4366	244	28	modified	modify	VERB
fnp-4366	244	29	leading	lead	VERB
fnp-4366	244	30	to	to	ADP
fnp-4366	244	31	overexpression	overexpression	NOUN
fnp-4366	244	32	or	or	CCONJ
fnp-4366	244	33	downregulation	downregulation	NOUN
fnp-4366	244	34	of	of	ADP
fnp-4366	244	35	ngfr	ngfr	NOUN
fnp-4366	244	36	.	.	PUNCT
fnp-4366	245	1	results	result	NOUN
fnp-4366	245	2	:	:	PUNCT
fnp-4366	245	3	transcriptome	transcriptome	ADJ
fnp-4366	245	4	profiling	profiling	NOUN
fnp-4366	245	5	of	of	ADP
fnp-4366	245	6	brafi	brafi	PROPN
fnp-4366	245	7	resistant	resistant	ADJ
fnp-4366	245	8	mm	mm	PROPN
fnp-4366	245	9	bm	bm	PROPN
fnp-4366	245	10	revealed	reveal	VERB
fnp-4366	245	11	that	that	SCONJ
fnp-4366	245	12	the	the	DET
fnp-4366	245	13	invasive	invasive	ADJ
fnp-4366	245	14	potential	potential	NOUN
fnp-4366	245	15	increased	increase	VERB
fnp-4366	245	16	during	during	ADP
fnp-4366	245	17	disease	disease	NOUN
fnp-4366	245	18	progression	progression	NOUN
fnp-4366	245	19	.	.	PUNCT
fnp-4366	246	1	this	this	DET
fnp-4366	246	2	process	process	NOUN
fnp-4366	246	3	was	be	AUX
fnp-4366	246	4	accompanied	accompany	VERB
fnp-4366	246	5	by	by	ADP
fnp-4366	246	6	upregulation	upregulation	NOUN
fnp-4366	246	7	of	of	ADP
fnp-4366	246	8	ngfr	ngfr	NOUN
fnp-4366	246	9	expression	expression	NOUN
fnp-4366	246	10	.	.	PUNCT
fnp-4366	247	1	moreover	moreover	ADV
fnp-4366	247	2	,	,	PUNCT
fnp-4366	247	3	it	it	PRON
fnp-4366	247	4	was	be	AUX
fnp-4366	247	5	preserved	preserve	VERB
fnp-4366	247	6	in	in	ADP
fnp-4366	247	7	patient	patient	ADJ
fnp-4366	247	8	derived	derive	VERB
fnp-4366	247	9	cells	cell	NOUN
fnp-4366	247	10	lines	line	NOUN
fnp-4366	247	11	,	,	PUNCT
fnp-4366	247	12	which	which	PRON
fnp-4366	247	13	demonstrated	demonstrate	VERB
fnp-4366	247	14	significantly	significantly	ADV
fnp-4366	247	15	higher	high	ADJ
fnp-4366	247	16	potential	potential	NOUN
fnp-4366	247	17	of	of	ADP
fnp-4366	247	18	two	two	NUM
fnp-4366	247	19	-	-	PUNCT
fnp-4366	247	20	dimensional	dimensional	ADJ
fnp-4366	247	21	in	in	ADP
fnp-4366	247	22	vitro	vitro	X
fnp-4366	247	23	migration	migration	NOUN
fnp-4366	247	24	(	(	PUNCT
fnp-4366	247	25	90	90	NUM
fnp-4366	247	26	%	%	NOUN
fnp-4366	247	27	vs.	vs.	ADP
fnp-4366	247	28	76	76	NUM
fnp-4366	247	29	%	%	NOUN
fnp-4366	247	30	after	after	ADP
fnp-4366	247	31	100	100	NUM
fnp-4366	247	32	hours	hour	NOUN
fnp-4366	247	33	)	)	PUNCT
fnp-4366	247	34	.	.	PUNCT
fnp-4366	248	1	furthermore	furthermore	ADV
fnp-4366	248	2	,	,	PUNCT
fnp-4366	248	3	cd271	cd271	PROPN
fnp-4366	248	4	knockdown	knockdown	NOUN
fnp-4366	248	5	was	be	AUX
fnp-4366	248	6	associated	associate	VERB
fnp-4366	248	7	with	with	ADP
fnp-4366	248	8	loss	loss	NOUN
fnp-4366	248	9	-	-	PUNCT
fnp-4366	248	10	of	of	ADP
fnp-4366	248	11	-	-	PUNCT
fnp-4366	248	12	expression	expression	NOUN
fnp-4366	248	13	of	of	ADP
fnp-4366	248	14	several	several	ADJ
fnp-4366	248	15	genes	gene	NOUN
fnp-4366	248	16	involved	involve	VERB
fnp-4366	248	17	in	in	ADP
fnp-4366	248	18	migration	migration	NOUN
fnp-4366	248	19	and	and	CCONJ
fnp-4366	248	20	invasion	invasion	NOUN
fnp-4366	248	21	.	.	PUNCT
fnp-4366	249	1	conclusions	conclusion	NOUN
fnp-4366	249	2	:	:	PUNCT
fnp-4366	249	3	brain	brain	NOUN
fnp-4366	249	4	metastases	metastasis	NOUN
fnp-4366	249	5	are	be	AUX
fnp-4366	249	6	the	the	DET
fnp-4366	249	7	major	major	ADJ
fnp-4366	249	8	cause	cause	NOUN
fnp-4366	249	9	of	of	ADP
fnp-4366	249	10	death	death	NOUN
fnp-4366	249	11	in	in	ADP
fnp-4366	249	12	metastasized	metastasized	ADJ
fnp-4366	249	13	mm	mm	NOUN
fnp-4366	249	14	.	.	PUNCT
fnp-4366	250	1	probably	probably	ADV
fnp-4366	250	2	,	,	PUNCT
fnp-4366	250	3	bm	bm	PROPN
fnp-4366	250	4	emerge	emerge	VERB
fnp-4366	250	5	and	and	CCONJ
fnp-4366	250	6	progress	progress	NOUN
fnp-4366	250	7	by	by	ADP
fnp-4366	250	8	the	the	DET
fnp-4366	250	9	concerted	concerted	ADJ
fnp-4366	250	10	interaction	interaction	NOUN
fnp-4366	250	11	of	of	ADP
fnp-4366	250	12	several	several	ADJ
fnp-4366	250	13	molecular	molecular	ADJ
fnp-4366	250	14	programs	program	NOUN
fnp-4366	250	15	that	that	PRON
fnp-4366	250	16	are	be	AUX
fnp-4366	250	17	triggered	trigger	VERB
fnp-4366	250	18	by	by	ADP
fnp-4366	250	19	cells	cell	NOUN
fnp-4366	250	20	of	of	ADP
fnp-4366	250	21	the	the	DET
fnp-4366	250	22	tumor	tumor	NOUN
fnp-4366	250	23	microenvironment	microenvironment	NOUN
fnp-4366	250	24	and/or	and/or	CCONJ
fnp-4366	250	25	in	in	ADP
fnp-4366	250	26	response	response	NOUN
fnp-4366	250	27	to	to	ADP
fnp-4366	250	28	therapeutic	therapeutic	ADJ
fnp-4366	250	29	interventions	intervention	NOUN
fnp-4366	250	30	.	.	PUNCT
fnp-4366	251	1	our	our	PRON
fnp-4366	251	2	study	study	NOUN
fnp-4366	251	3	provides	provide	VERB
fnp-4366	251	4	a	a	DET
fnp-4366	251	5	longitudinal	longitudinal	ADJ
fnp-4366	251	6	perspective	perspective	NOUN
fnp-4366	251	7	on	on	ADP
fnp-4366	251	8	the	the	DET
fnp-4366	251	9	progression	progression	NOUN
fnp-4366	251	10	of	of	ADP
fnp-4366	251	11	brain	brain	NOUN
fnp-4366	251	12	metastasis	metastasis	NOUN
fnp-4366	251	13	and	and	CCONJ
fnp-4366	251	14	their	their	PRON
fnp-4366	251	15	mechanisms	mechanism	NOUN
fnp-4366	251	16	leading	lead	VERB
fnp-4366	251	17	to	to	ADP
fnp-4366	251	18	therapy	therapy	NOUN
fnp-4366	251	19	resistance	resistance	NOUN
fnp-4366	251	20	.	.	PUNCT
fnp-4366	251	21	  	  	SPACE
fnp-4366	252	1	2.08	2.08	NUM
fnp-4366	252	2	free	free	ADJ
fnp-4366	252	3	neuropathol	neuropathol	NOUN
fnp-4366	252	4	3:20:29	3:20:29	NUM
fnp-4366	252	5	a	a	DET
fnp-4366	252	6	peripheral	peripheral	ADJ
fnp-4366	252	7	nerve	nerve	NOUN
fnp-4366	252	8	sheath	sheath	NOUN
fnp-4366	252	9	tumor	tumor	NOUN
fnp-4366	252	10	syndrome	syndrome	NOUN
fnp-4366	252	11	caused	cause	VERB
fnp-4366	252	12	by	by	ADP
fnp-4366	252	13	postzygotic	postzygotic	ADJ
fnp-4366	252	14	erbb2	erbb2	PROPN
fnp-4366	252	15	mutations	mutation	NOUN
fnp-4366	252	16	michael	michael	PROPN
fnp-4366	252	17	ronellenfitsch1,2,3,4	ronellenfitsch1,2,3,4	PROPN
fnp-4366	252	18	,	,	PUNCT
fnp-4366	252	19	isabel	isabel	PROPN
fnp-4366	252	20	gugel5	gugel5	PROPN
fnp-4366	252	21	,	,	PUNCT
fnp-4366	252	22	dusica	dusica	NOUN
fnp-4366	252	23	babovic	babovic	NOUN
fnp-4366	252	24	-	-	PUNCT
fnp-4366	252	25	vuksanovic6	vuksanovic6	PROPN
fnp-4366	252	26	,	,	PUNCT
fnp-4366	252	27	maximilian	maximilian	PROPN
fnp-4366	252	28	rauch2,7	rauch2,7	PROPN
fnp-4366	252	29	,	,	PUNCT
fnp-4366	252	30	jens	jens	PROPN
fnp-4366	252	31	schittenhelm5	schittenhelm5	PROPN
fnp-4366	252	32	,	,	PUNCT
fnp-4366	252	33	martin	martin	PROPN
fnp-4366	252	34	u.	u.	PROPN
fnp-4366	252	35	schuhmann5	schuhmann5	PROPN
fnp-4366	252	36	,	,	PUNCT
fnp-4366	252	37	silvia	silvia	PROPN
fnp-4366	252	38	hofer8	hofer8	PROPN
fnp-4366	252	39	,	,	PUNCT
fnp-4366	252	40	martina	martina	PROPN
fnp-4366	252	41	kirchner9	kirchner9	PROPN
fnp-4366	252	42	,	,	PUNCT
fnp-4366	252	43	gerhard	gerhard	PROPN
fnp-4366	252	44	marquardt10	marquardt10	PROPN
fnp-4366	252	45	,	,	PUNCT
fnp-4366	252	46	rouzbeh	rouzbeh	PROPN
fnp-4366	252	47	banan911	banan911	PROPN
fnp-4366	252	48	,	,	PUNCT
fnp-4366	252	49	benedikt	benedikt	PROPN
fnp-4366	252	50	sauer1,3	sauer1,3	PROPN
fnp-4366	252	51	,	,	PUNCT
fnp-4366	252	52	ulrich	ulrich	PROPN
fnp-4366	252	53	schüller12,13,14	schüller12,13,14	PROPN
fnp-4366	252	54	,	,	PUNCT
fnp-4366	252	55	werner	werner	PROPN
fnp-4366	252	56	paulus15	paulus15	PROPN
fnp-4366	252	57	,	,	PUNCT
fnp-4366	252	58	matthias	matthias	PROPN
fnp-4366	252	59	meinhardt16	meinhardt16	PROPN
fnp-4366	252	60	,	,	PUNCT
fnp-4366	252	61	tareq	tareq	PROPN
fnp-4366	252	62	juratli16	juratli16	PROPN
fnp-4366	252	63	,	,	PUNCT
fnp-4366	252	64	albrecht	albrecht	PROPN
fnp-4366	252	65	stenzinger9	stenzinger9	PROPN
fnp-4366	252	66	,	,	PUNCT
fnp-4366	252	67	stefan	stefan	PROPN
fnp-4366	252	68	fröhling17,18	fröhling17,18	PROPN
fnp-4366	252	69	,	,	PUNCT
fnp-4366	252	70	eric	eric	PROPN
fnp-4366	252	71	legius19	legius19	PROPN
fnp-4366	252	72	,	,	PUNCT
fnp-4366	252	73	andreas	andreas	PROPN
fnp-4366	252	74	von	von	PROPN
fnp-4366	252	75	deimling9,11	deimling9,11	PROPN
fnp-4366	252	76	,	,	PUNCT
fnp-4366	252	77	felix	felix	PROPN
fnp-4366	252	78	sahm9,11	sahm9,11	PROPN
fnp-4366	252	79	,	,	PUNCT
fnp-4366	252	80	joachim	joachim	PROPN
fnp-4366	252	81	p.	p.	PROPN
fnp-4366	252	82	steinbach1,2,3,4	steinbach1,2,3,4	PROPN
fnp-4366	252	83	,	,	PUNCT
fnp-4366	252	84	patrick	patrick	PROPN
fnp-4366	252	85	harter2,3,10	harter2,3,10	PROPN
fnp-4366	252	86	,	,	PUNCT
fnp-4366	252	87	victor	victor	NOUN
fnp-4366	252	88	-	-	PUNCT
fnp-4366	252	89	felix	felix	PROPN
fnp-4366	252	90	mautner12	mautner12	NOUN
fnp-4366	252	91	,	,	PUNCT
fnp-4366	252	92	david	david	PROPN
fnp-4366	252	93	reuss11,20	reuss11,20	PROPN
fnp-4366	252	94	1	1	NUM
fnp-4366	252	95	dr	dr	PROPN
fnp-4366	252	96	.	.	PROPN
fnp-4366	252	97	senckenberg	senckenberg	PROPN
fnp-4366	252	98	institute	institute	PROPN
fnp-4366	252	99	of	of	ADP
fnp-4366	252	100	neurooncology	neurooncology	PROPN
fnp-4366	252	101	,	,	PUNCT
fnp-4366	252	102	frankfurt	frankfurt	PROPN
fnp-4366	252	103	,	,	PUNCT
fnp-4366	252	104	deutschland	deutschland	NOUN
fnp-4366	252	105	2	2	NUM
fnp-4366	252	106	university	university	NOUN
fnp-4366	252	107	cancer	cancer	NOUN
fnp-4366	252	108	center	center	NOUN
fnp-4366	252	109	(	(	PUNCT
fnp-4366	252	110	uct	uct	PROPN
fnp-4366	252	111	)	)	PUNCT
fnp-4366	252	112	frankfurt	frankfurt	PROPN
fnp-4366	252	113	,	,	PUNCT
fnp-4366	252	114	frankfurt	frankfurt	PROPN
fnp-4366	252	115	,	,	PUNCT
fnp-4366	252	116	deutschland	deutschland	NOUN
fnp-4366	252	117	3	3	NUM
fnp-4366	252	118	german	german	ADJ
fnp-4366	252	119	cancer	cancer	NOUN
fnp-4366	252	120	consortium	consortium	NOUN
fnp-4366	252	121	(	(	PUNCT
fnp-4366	252	122	dktk	dktk	NOUN
fnp-4366	252	123	)	)	PUNCT
fnp-4366	252	124	,	,	PUNCT
fnp-4366	252	125	frankfurt	frankfurt	PROPN
fnp-4366	252	126	,	,	PUNCT
fnp-4366	252	127	deutschland	deutschland	NOUN
fnp-4366	252	128	4	4	NUM
fnp-4366	252	129	frankfurt	frankfurt	PROPN
fnp-4366	252	130	cancer	cancer	PROPN
fnp-4366	252	131	institute	institute	PROPN
fnp-4366	252	132	,	,	PUNCT
fnp-4366	252	133	frankfurt	frankfurt	PROPN
fnp-4366	252	134	,	,	PUNCT
fnp-4366	252	135	deutschland	deutschland	NOUN
fnp-4366	252	136	5	5	NUM
fnp-4366	252	137	university	university	NOUN
fnp-4366	252	138	hospital	hospital	NOUN
fnp-4366	252	139	tübingen	tübingen	PROPN
fnp-4366	252	140	,	,	PUNCT
fnp-4366	252	141	tübingen	tübingen	PROPN
fnp-4366	252	142	,	,	PUNCT
fnp-4366	252	143	deutschland	deutschland	NOUN
fnp-4366	252	144	6	6	NUM
fnp-4366	252	145	mayo	mayo	NOUN
fnp-4366	252	146	clinic	clinic	PROPN
fnp-4366	252	147	college	college	PROPN
fnp-4366	252	148	of	of	ADP
fnp-4366	252	149	medicine	medicine	NOUN
fnp-4366	252	150	,	,	PUNCT
fnp-4366	252	151	rochester	rochester	PROPN
fnp-4366	252	152	,	,	PUNCT
fnp-4366	252	153	united	united	PROPN
fnp-4366	252	154	states	states	PROPN
fnp-4366	252	155	7	7	NUM
fnp-4366	252	156	goethe	goethe	PROPN
fnp-4366	252	157	university	university	NOUN
fnp-4366	252	158	hospital	hospital	NOUN
fnp-4366	252	159	,	,	PUNCT
fnp-4366	252	160	frankfurt	frankfurt	PROPN
fnp-4366	252	161	,	,	PUNCT
fnp-4366	252	162	deutschland	deutschland	NOUN
fnp-4366	252	163	8	8	NUM
fnp-4366	252	164	university	university	NOUN
fnp-4366	252	165	hospital	hospital	NOUN
fnp-4366	252	166	and	and	CCONJ
fnp-4366	252	167	university	university	NOUN
fnp-4366	252	168	of	of	ADP
fnp-4366	252	169	zurich	zurich	PROPN
fnp-4366	252	170	,	,	PUNCT
fnp-4366	252	171	zürich	zürich	PROPN
fnp-4366	252	172	,	,	PUNCT
fnp-4366	252	173	switzerland	switzerland	PROPN
fnp-4366	252	174	9	9	NUM
fnp-4366	252	175	heidelberg	heidelberg	PROPN
fnp-4366	252	176	university	university	PROPN
fnp-4366	252	177	hospital	hospital	NOUN
fnp-4366	252	178	,	,	PUNCT
fnp-4366	252	179	heidelberg	heidelberg	PROPN
fnp-4366	252	180	,	,	PUNCT
fnp-4366	252	181	deutschland	deutschland	NOUN
fnp-4366	252	182	10	10	NUM
fnp-4366	252	183	university	university	NOUN
fnp-4366	252	184	hospital	hospital	NOUN
fnp-4366	252	185	frankfurt	frankfurt	PROPN
fnp-4366	252	186	,	,	PUNCT
fnp-4366	252	187	frankfurt	frankfurt	PROPN
fnp-4366	252	188	,	,	PUNCT
fnp-4366	252	189	deutschland	deutschland	NOUN
fnp-4366	252	190	11	11	NUM
fnp-4366	252	191	dkfz	dkfz	NOUN
fnp-4366	252	192	,	,	PUNCT
fnp-4366	252	193	heidelberg	heidelberg	PROPN
fnp-4366	252	194	,	,	PUNCT
fnp-4366	252	195	deutschland	deutschland	NOUN
fnp-4366	252	196	12	12	NUM
fnp-4366	252	197	university	university	NOUN
fnp-4366	252	198	hospital	hospital	NOUN
fnp-4366	252	199	hamburg	hamburg	PROPN
fnp-4366	252	200	-	-	PUNCT
fnp-4366	252	201	eppendorf	eppendorf	PROPN
fnp-4366	252	202	,	,	PUNCT
fnp-4366	252	203	hamburg	hamburg	PROPN
fnp-4366	252	204	,	,	PUNCT
fnp-4366	252	205	deutschland	deutschland	NOUN
fnp-4366	252	206	13	13	NUM
fnp-4366	252	207	university	university	NOUN
fnp-4366	252	208	medical	medical	ADJ
fnp-4366	252	209	center	center	PROPN
fnp-4366	252	210	hamburg	hamburg	PROPN
fnp-4366	252	211	-	-	PUNCT
fnp-4366	252	212	eppendorf	eppendorf	PROPN
fnp-4366	252	213	,	,	PUNCT
fnp-4366	252	214	hamburg	hamburg	PROPN
fnp-4366	252	215	,	,	PUNCT
fnp-4366	252	216	deutschland	deutschland	NOUN
fnp-4366	252	217	14	14	NUM
fnp-4366	252	218	research	research	NOUN
fnp-4366	252	219	institute	institute	NOUN
fnp-4366	252	220	children	child	NOUN
fnp-4366	252	221	's	's	PART
fnp-4366	252	222	cancer	cancer	NOUN
fnp-4366	252	223	center	center	NOUN
fnp-4366	252	224	hamburg	hamburg	PROPN
fnp-4366	252	225	,	,	PUNCT
fnp-4366	252	226	hamburg	hamburg	PROPN
fnp-4366	252	227	,	,	PUNCT
fnp-4366	252	228	deutschland	deutschland	NOUN
fnp-4366	252	229	15	15	NUM
fnp-4366	252	230	university	university	NOUN
fnp-4366	252	231	hospital	hospital	NOUN
fnp-4366	252	232	münster	münster	NOUN
fnp-4366	252	233	,	,	PUNCT
fnp-4366	252	234	münster	münster	NOUN
fnp-4366	252	235	,	,	PUNCT
fnp-4366	252	236	deutschland	deutschland	NOUN
fnp-4366	252	237	16	16	NUM
fnp-4366	252	238	university	university	NOUN
fnp-4366	252	239	hospital	hospital	NOUN
fnp-4366	252	240	carl	carl	PROPN
fnp-4366	252	241	gustav	gustav	PROPN
fnp-4366	252	242	carus	carus	PROPN
fnp-4366	252	243	,	,	PUNCT
fnp-4366	252	244	dresden	dresden	PROPN
fnp-4366	252	245	,	,	PUNCT
fnp-4366	252	246	deutschland	deutschland	PROPN
fnp-4366	252	247	17	17	NUM
fnp-4366	252	248	nct	nct	PROPN
fnp-4366	252	249	heidelberg	heidelberg	NOUN
fnp-4366	252	250	and	and	CCONJ
fnp-4366	252	251	dkfz	dkfz	PROPN
fnp-4366	252	252	,	,	PUNCT
fnp-4366	252	253	heidelberg	heidelberg	PROPN
fnp-4366	252	254	,	,	PUNCT
fnp-4366	252	255	deutschland	deutschland	NOUN
fnp-4366	252	256	18	18	NUM
fnp-4366	252	257	dktk	dktk	NOUN
fnp-4366	252	258	,	,	PUNCT
fnp-4366	252	259	heidelberg	heidelberg	NOUN
fnp-4366	252	260	,	,	PUNCT
fnp-4366	252	261	deutschland	deutschland	NOUN
fnp-4366	252	262	19	19	NUM
fnp-4366	252	263	ku	ku	PROPN
fnp-4366	252	264	leuven	leuven	PROPN
fnp-4366	252	265	and	and	CCONJ
fnp-4366	252	266	university	university	NOUN
fnp-4366	252	267	hospital	hospital	NOUN
fnp-4366	252	268	,	,	PUNCT
fnp-4366	252	269	leuven	leuven	PROPN
fnp-4366	252	270	,	,	PUNCT
fnp-4366	252	271	belgium	belgium	NOUN
fnp-4366	252	272	20	20	NUM
fnp-4366	252	273	universitätsklinikum	universitätsklinikum	NOUN
fnp-4366	252	274	heidelberg	heidelberg	NOUN
fnp-4366	252	275	,	,	PUNCT
fnp-4366	252	276	neuropathologie	neuropathologie	NOUN
fnp-4366	252	277	,	,	PUNCT
fnp-4366	252	278	heidelberg	heidelberg	NOUN
fnp-4366	252	279	,	,	PUNCT
fnp-4366	252	280	deutschland	deutschland	NOUN
fnp-4366	252	281	introduction	introduction	NOUN
fnp-4366	252	282	:	:	PUNCT
fnp-4366	252	283	peripheral	peripheral	ADJ
fnp-4366	252	284	nerve	nerve	NOUN
fnp-4366	252	285	sheath	sheath	NOUN
fnp-4366	252	286	tumors	tumor	NOUN
fnp-4366	252	287	(	(	PUNCT
fnp-4366	252	288	nst	nst	NOUN
fnp-4366	252	289	)	)	PUNCT
fnp-4366	252	290	are	be	AUX
fnp-4366	252	291	common	common	ADJ
fnp-4366	252	292	manifestations	manifestation	NOUN
fnp-4366	252	293	of	of	ADP
fnp-4366	252	294	different	different	ADJ
fnp-4366	252	295	tumor	tumor	NOUN
fnp-4366	252	296	syndromes	syndrome	NOUN
fnp-4366	252	297	within	within	ADP
fnp-4366	252	298	the	the	DET
fnp-4366	252	299	neurofibromatosis	neurofibromatosis	NOUN
fnp-4366	252	300	spectrum	spectrum	NOUN
fnp-4366	252	301	,	,	PUNCT
fnp-4366	252	302	comprised	comprise	VERB
fnp-4366	252	303	of	of	ADP
fnp-4366	252	304	nf1	nf1	NOUN
fnp-4366	252	305	,	,	PUNCT
fnp-4366	252	306	nf2	nf2	ADJ
fnp-4366	252	307	and	and	CCONJ
fnp-4366	252	308	schwannomatosis	schwannomatosis	NOUN
fnp-4366	252	309	.	.	PUNCT
fnp-4366	253	1	these	these	PRON
fnp-4366	253	2	are	be	AUX
fnp-4366	253	3	caused	cause	VERB
fnp-4366	253	4	by	by	ADP
fnp-4366	253	5	inactivating	inactivate	VERB
fnp-4366	253	6	germline	germline	NOUN
fnp-4366	253	7	mutations	mutation	NOUN
fnp-4366	253	8	in	in	ADP
fnp-4366	253	9	the	the	DET
fnp-4366	253	10	nf1	nf1	NOUN
fnp-4366	253	11	,	,	PUNCT
fnp-4366	253	12	nf2	nf2	ADJ
fnp-4366	253	13	,	,	PUNCT
fnp-4366	253	14	smarcb1	smarcb1	NOUN
fnp-4366	253	15	or	or	CCONJ
fnp-4366	253	16	lztr1	lztr1	PROPN
fnp-4366	253	17	tumor	tumor	NOUN
fnp-4366	253	18	suppressor	suppressor	NOUN
fnp-4366	253	19	genes	gene	NOUN
fnp-4366	253	20	respectively	respectively	ADV
fnp-4366	253	21	.	.	PUNCT
fnp-4366	254	1	neurofibromas	neurofibroma	NOUN
fnp-4366	254	2	are	be	AUX
fnp-4366	254	3	closely	closely	ADV
fnp-4366	254	4	associated	associate	VERB
fnp-4366	254	5	with	with	ADP
fnp-4366	254	6	nf1	nf1	NOUN
fnp-4366	254	7	and	and	CCONJ
fnp-4366	254	8	schwannomas	schwannoma	NOUN
fnp-4366	254	9	occur	occur	VERB
fnp-4366	254	10	in	in	ADP
fnp-4366	254	11	both	both	CCONJ
fnp-4366	254	12	nf2	nf2	ADJ
fnp-4366	254	13	and	and	CCONJ
fnp-4366	254	14	schwannomatosis	schwannomatosis	NOUN
fnp-4366	254	15	.	.	PUNCT
fnp-4366	255	1	occurrence	occurrence	NOUN
fnp-4366	255	2	of	of	ADP
fnp-4366	255	3	neurofibroma	neurofibroma	NOUN
fnp-4366	255	4	/	/	SYM
fnp-4366	255	5	schwannoma	schwannoma	NOUN
fnp-4366	255	6	hybrid	hybrid	ADJ
fnp-4366	255	7	tumors	tumor	NOUN
fnp-4366	255	8	is	be	AUX
fnp-4366	255	9	reported	report	VERB
fnp-4366	255	10	in	in	ADP
fnp-4366	255	11	all	all	DET
fnp-4366	255	12	these	these	DET
fnp-4366	255	13	syndromes	syndrome	NOUN
fnp-4366	255	14	.	.	PUNCT
fnp-4366	256	1	we	we	PRON
fnp-4366	256	2	recently	recently	ADV
fnp-4366	256	3	described	describe	VERB
fnp-4366	256	4	erbb2	erbb2	ADJ
fnp-4366	256	5	mutations	mutation	NOUN
fnp-4366	256	6	in	in	ADP
fnp-4366	256	7	a	a	DET
fnp-4366	256	8	significant	significant	ADJ
fnp-4366	256	9	portion	portion	NOUN
fnp-4366	256	10	of	of	ADP
fnp-4366	256	11	neurofibroma	neurofibroma	NOUN
fnp-4366	256	12	/	/	SYM
fnp-4366	256	13	schwannoma	schwannoma	NOUN
fnp-4366	256	14	hybrid	hybrid	ADJ
fnp-4366	256	15	nerve	nerve	NOUN
fnp-4366	256	16	sheath	sheath	NOUN
fnp-4366	256	17	tumors	tumor	NOUN
fnp-4366	256	18	.	.	PUNCT
fnp-4366	257	1	based	base	VERB
fnp-4366	257	2	on	on	ADP
fnp-4366	257	3	clinical	clinical	ADJ
fnp-4366	257	4	criteria	criterion	NOUN
fnp-4366	257	5	,	,	PUNCT
fnp-4366	257	6	these	these	DET
fnp-4366	257	7	cases	case	NOUN
fnp-4366	257	8	resembled	resemble	VERB
fnp-4366	257	9	schwannomatosis	schwannomatosis	NOUN
fnp-4366	257	10	.	.	PUNCT
fnp-4366	258	1	however	however	ADV
fnp-4366	258	2	,	,	PUNCT
fnp-4366	258	3	the	the	DET
fnp-4366	258	4	somatic	somatic	ADJ
fnp-4366	258	5	genetic	genetic	ADJ
fnp-4366	258	6	profile	profile	NOUN
fnp-4366	258	7	of	of	ADP
fnp-4366	258	8	the	the	DET
fnp-4366	258	9	tumors	tumor	NOUN
fnp-4366	258	10	was	be	AUX
fnp-4366	258	11	distinct	distinct	ADJ
fnp-4366	258	12	.	.	PUNCT
fnp-4366	259	1	additionally	additionally	ADV
fnp-4366	259	2	,	,	PUNCT
fnp-4366	259	3	features	feature	VERB
fnp-4366	259	4	untypical	untypical	ADJ
fnp-4366	259	5	of	of	ADP
fnp-4366	259	6	schwannomatosis	schwannomatosis	NOUN
fnp-4366	259	7	were	be	AUX
fnp-4366	259	8	present	present	ADJ
fnp-4366	259	9	,	,	PUNCT
fnp-4366	259	10	resembling	resemble	VERB
fnp-4366	259	11	previously	previously	ADV
fnp-4366	259	12	published	publish	VERB
fnp-4366	259	13	descriptions	description	NOUN
fnp-4366	259	14	of	of	ADP
fnp-4366	259	15	four	four	NUM
fnp-4366	259	16	patients	patient	NOUN
fnp-4366	259	17	with	with	ADP
fnp-4366	259	18	distinctive	distinctive	ADJ
fnp-4366	259	19	but	but	CCONJ
fnp-4366	259	20	unclassifiable	unclassifiable	ADJ
fnp-4366	259	21	clinical	clinical	ADJ
fnp-4366	259	22	and	and	CCONJ
fnp-4366	259	23	pathological	pathological	ADJ
fnp-4366	259	24	findings	finding	NOUN
fnp-4366	259	25	.	.	PUNCT
fnp-4366	260	1	objectives	objective	NOUN
fnp-4366	260	2	:	:	PUNCT
fnp-4366	260	3	the	the	DET
fnp-4366	260	4	aim	aim	NOUN
fnp-4366	260	5	of	of	ADP
fnp-4366	260	6	the	the	DET
fnp-4366	260	7	study	study	NOUN
fnp-4366	260	8	was	be	AUX
fnp-4366	260	9	the	the	DET
fnp-4366	260	10	clinicopathological	clinicopathological	ADJ
fnp-4366	260	11	and	and	CCONJ
fnp-4366	260	12	molecular	molecular	ADJ
fnp-4366	260	13	characterization	characterization	NOUN
fnp-4366	260	14	of	of	ADP
fnp-4366	260	15	erbb2	erbb2	ADJ
fnp-4366	260	16	-	-	PUNCT
fnp-4366	260	17	mutant	mutant	ADJ
fnp-4366	260	18	peripheral	peripheral	ADJ
fnp-4366	260	19	nerve	nerve	NOUN
fnp-4366	260	20	sheath	sheath	NOUN
fnp-4366	260	21	tumors	tumor	NOUN
fnp-4366	260	22	.	.	PUNCT
fnp-4366	261	1	methods	method	NOUN
fnp-4366	261	2	:	:	PUNCT
fnp-4366	261	3	tumors	tumor	NOUN
fnp-4366	261	4	were	be	AUX
fnp-4366	261	5	evaluated	evaluate	VERB
fnp-4366	261	6	by	by	ADP
fnp-4366	261	7	histology	histology	NOUN
fnp-4366	261	8	.	.	PUNCT
fnp-4366	262	1	next	next	ADJ
fnp-4366	262	2	generation	generation	NOUN
fnp-4366	262	3	sequencing	sequence	VERB
fnp-4366	262	4	(	(	PUNCT
fnp-4366	262	5	hd	hd	NOUN
fnp-4366	262	6	-	-	NOUN
fnp-4366	262	7	panel	panel	NOUN
fnp-4366	262	8	or	or	CCONJ
fnp-4366	262	9	whole	whole	ADJ
fnp-4366	262	10	exome	exome	NOUN
fnp-4366	262	11	sequencing	sequencing	NOUN
fnp-4366	262	12	)	)	PUNCT
fnp-4366	262	13	was	be	AUX
fnp-4366	262	14	used	use	VERB
fnp-4366	262	15	to	to	PART
fnp-4366	262	16	determine	determine	VERB
fnp-4366	262	17	the	the	DET
fnp-4366	262	18	presence	presence	NOUN
fnp-4366	262	19	of	of	ADP
fnp-4366	262	20	an	an	DET
fnp-4366	262	21	erbb2	erbb2	ADJ
fnp-4366	262	22	mutation	mutation	NOUN
fnp-4366	262	23	in	in	ADP
fnp-4366	262	24	at	at	ADV
fnp-4366	262	25	least	least	ADV
fnp-4366	262	26	one	one	NUM
fnp-4366	262	27	tumor	tumor	NOUN
fnp-4366	262	28	of	of	ADP
fnp-4366	262	29	every	every	DET
fnp-4366	262	30	patient	patient	NOUN
fnp-4366	262	31	.	.	PUNCT
fnp-4366	263	1	pyro	pyro	NOUN
fnp-4366	263	2	-	-	PUNCT
fnp-4366	263	3	sequencing	sequencing	NOUN
fnp-4366	263	4	was	be	AUX
fnp-4366	263	5	used	use	VERB
fnp-4366	263	6	to	to	PART
fnp-4366	263	7	verify	verify	VERB
fnp-4366	263	8	erbb2	erbb2	ADJ
fnp-4366	263	9	mutations	mutation	NOUN
fnp-4366	263	10	and	and	CCONJ
fnp-4366	263	11	to	to	PART
fnp-4366	263	12	determine	determine	VERB
fnp-4366	263	13	their	their	PRON
fnp-4366	263	14	presence	presence	NOUN
fnp-4366	263	15	in	in	ADP
fnp-4366	263	16	additional	additional	ADJ
fnp-4366	263	17	tumors	tumor	NOUN
fnp-4366	263	18	from	from	ADP
fnp-4366	263	19	a	a	DET
fnp-4366	263	20	given	give	VERB
fnp-4366	263	21	patient	patient	NOUN
fnp-4366	263	22	.	.	PUNCT
fnp-4366	264	1	850k	850k	NOUN
fnp-4366	264	2	methylation	methylation	NOUN
fnp-4366	264	3	profiling	profiling	NOUN
fnp-4366	264	4	was	be	AUX
fnp-4366	264	5	used	use	VERB
fnp-4366	264	6	for	for	ADP
fnp-4366	264	7	additional	additional	ADJ
fnp-4366	264	8	characterizations	characterization	NOUN
fnp-4366	264	9	.	.	PUNCT
fnp-4366	265	1	results	result	NOUN
fnp-4366	265	2	:	:	PUNCT
fnp-4366	265	3	we	we	PRON
fnp-4366	265	4	identified	identify	VERB
fnp-4366	265	5	13	13	NUM
fnp-4366	265	6	non	non	ADJ
fnp-4366	265	7	-	-	ADJ
fnp-4366	265	8	related	related	ADJ
fnp-4366	265	9	patients	patient	NOUN
fnp-4366	265	10	with	with	ADP
fnp-4366	265	11	erbb2	erbb2	PROPN
fnp-4366	265	12	mutant	mutant	PROPN
fnp-4366	265	13	nst	nst	PROPN
fnp-4366	265	14	,	,	PUNCT
fnp-4366	265	15	including	include	VERB
fnp-4366	265	16	all	all	PRON
fnp-4366	265	17	4	4	NUM
fnp-4366	265	18	previously	previously	ADV
fnp-4366	265	19	published	publish	VERB
fnp-4366	265	20	patients	patient	NOUN
fnp-4366	265	21	with	with	ADP
fnp-4366	265	22	an	an	DET
fnp-4366	265	23	unclassified	unclassified	ADJ
fnp-4366	265	24	syndrome	syndrome	NOUN
fnp-4366	265	25	.	.	PUNCT
fnp-4366	266	1	all	all	DET
fnp-4366	266	2	but	but	SCONJ
fnp-4366	266	3	two	two	NUM
fnp-4366	266	4	patients	patient	NOUN
fnp-4366	266	5	were	be	AUX
fnp-4366	266	6	females	female	NOUN
fnp-4366	266	7	and	and	CCONJ
fnp-4366	266	8	tumors	tumor	NOUN
fnp-4366	266	9	developed	develop	VERB
fnp-4366	266	10	slowly	slowly	ADV
fnp-4366	266	11	during	during	ADP
fnp-4366	266	12	adulthood	adulthood	NOUN
fnp-4366	266	13	.	.	PUNCT
fnp-4366	267	1	all	all	DET
fnp-4366	267	2	patients	patient	NOUN
fnp-4366	267	3	had	have	VERB
fnp-4366	267	4	multiple	multiple	ADJ
fnp-4366	267	5	nst	nst	PROPN
fnp-4366	267	6	,	,	PUNCT
fnp-4366	267	7	which	which	PRON
fnp-4366	267	8	were	be	AUX
fnp-4366	267	9	restricted	restrict	VERB
fnp-4366	267	10	to	to	ADP
fnp-4366	267	11	a	a	DET
fnp-4366	267	12	specific	specific	ADJ
fnp-4366	267	13	anatomic	anatomic	ADJ
fnp-4366	267	14	region	region	NOUN
fnp-4366	267	15	in	in	ADP
fnp-4366	267	16	several	several	ADJ
fnp-4366	267	17	patients	patient	NOUN
fnp-4366	267	18	while	while	SCONJ
fnp-4366	267	19	a	a	DET
fnp-4366	267	20	more	more	ADV
fnp-4366	267	21	widespread	widespread	ADJ
fnp-4366	267	22	distribution	distribution	NOUN
fnp-4366	267	23	of	of	ADP
fnp-4366	267	24	tumors	tumor	NOUN
fnp-4366	267	25	was	be	AUX
fnp-4366	267	26	present	present	ADJ
fnp-4366	267	27	in	in	ADP
fnp-4366	267	28	others	other	NOUN
fnp-4366	267	29	.	.	PUNCT
fnp-4366	268	1	the	the	DET
fnp-4366	268	2	histology	histology	NOUN
fnp-4366	268	3	showed	show	VERB
fnp-4366	268	4	quite	quite	ADV
fnp-4366	268	5	distinctive	distinctive	ADJ
fnp-4366	268	6	features	feature	NOUN
fnp-4366	268	7	within	within	ADP
fnp-4366	268	8	the	the	DET
fnp-4366	268	9	spectrum	spectrum	NOUN
fnp-4366	268	10	of	of	ADP
fnp-4366	268	11	hybrid	hybrid	ADJ
fnp-4366	268	12	nerve	nerve	NOUN
fnp-4366	268	13	sheath	sheath	NOUN
fnp-4366	268	14	tumors	tumor	NOUN
fnp-4366	268	15	.	.	PUNCT
fnp-4366	269	1	strikingly	strikingly	ADV
fnp-4366	269	2	,	,	PUNCT
fnp-4366	269	3	in	in	ADP
fnp-4366	269	4	all	all	DET
fnp-4366	269	5	patients	patient	NOUN
fnp-4366	269	6	,	,	PUNCT
fnp-4366	269	7	tumors	tumor	NOUN
fnp-4366	269	8	from	from	ADP
fnp-4366	269	9	distinct	distinct	ADJ
fnp-4366	269	10	anatomic	anatomic	ADJ
fnp-4366	269	11	locations	location	NOUN
fnp-4366	269	12	harbored	harbor	VERB
fnp-4366	269	13	the	the	DET
fnp-4366	269	14	very	very	ADV
fnp-4366	269	15	same	same	ADJ
fnp-4366	269	16	activating	activate	VERB
fnp-4366	269	17	erbb2	erbb2	ADJ
fnp-4366	269	18	mutation	mutation	NOUN
fnp-4366	269	19	.	.	PUNCT
fnp-4366	270	1	the	the	DET
fnp-4366	270	2	median	median	ADJ
fnp-4366	270	3	mutant	mutant	ADJ
fnp-4366	270	4	allele	allele	NOUN
fnp-4366	270	5	frequency	frequency	NOUN
fnp-4366	270	6	of	of	ADP
fnp-4366	270	7	12	12	NUM
fnp-4366	270	8	%	%	NOUN
fnp-4366	270	9	was	be	AUX
fnp-4366	270	10	comparatively	comparatively	ADV
fnp-4366	270	11	low	low	ADJ
fnp-4366	270	12	(	(	PUNCT
fnp-4366	270	13	range	range	NOUN
fnp-4366	270	14	4%-23	4%-23	NUM
fnp-4366	270	15	%	%	NOUN
fnp-4366	270	16	)	)	PUNCT
fnp-4366	270	17	suggesting	suggest	VERB
fnp-4366	270	18	that	that	SCONJ
fnp-4366	270	19	only	only	ADV
fnp-4366	270	20	a	a	DET
fnp-4366	270	21	subpopulation	subpopulation	NOUN
fnp-4366	270	22	of	of	ADP
fnp-4366	270	23	cells	cell	NOUN
fnp-4366	270	24	harbored	harbor	VERB
fnp-4366	270	25	the	the	DET
fnp-4366	270	26	mutation	mutation	NOUN
fnp-4366	270	27	.	.	PUNCT
fnp-4366	271	1	no	no	DET
fnp-4366	271	2	other	other	ADJ
fnp-4366	271	3	candidate	candidate	NOUN
fnp-4366	271	4	driver	driver	NOUN
fnp-4366	271	5	alteration	alteration	NOUN
fnp-4366	271	6	was	be	AUX
fnp-4366	271	7	found	find	VERB
fnp-4366	271	8	by	by	ADP
fnp-4366	271	9	ngs	ng	NOUN
fnp-4366	271	10	panel	panel	NOUN
fnp-4366	271	11	or	or	CCONJ
fnp-4366	271	12	wes	wes	PROPN
fnp-4366	271	13	and	and	CCONJ
fnp-4366	271	14	rna	rna	NOUN
fnp-4366	271	15	-	-	PUNCT
fnp-4366	271	16	sequencing	sequencing	NOUN
fnp-4366	271	17	.	.	PUNCT
fnp-4366	272	1	dna	dna	PROPN
fnp-4366	272	2	methylation	methylation	NOUN
fnp-4366	272	3	profiling	profiling	NOUN
fnp-4366	272	4	provided	provide	VERB
fnp-4366	272	5	evidence	evidence	NOUN
fnp-4366	272	6	for	for	ADP
fnp-4366	272	7	a	a	DET
fnp-4366	272	8	distinctive	distinctive	ADJ
fnp-4366	272	9	epigenetic	epigenetic	ADJ
fnp-4366	272	10	profile	profile	NOUN
fnp-4366	272	11	of	of	ADP
fnp-4366	272	12	erbb2	erbb2	ADJ
fnp-4366	272	13	-	-	PUNCT
fnp-4366	272	14	mutant	mutant	ADJ
fnp-4366	272	15	nsts	nst	NOUN
fnp-4366	272	16	.	.	PUNCT
fnp-4366	273	1	no	no	DET
fnp-4366	273	2	chromosomal	chromosomal	ADJ
fnp-4366	273	3	copy	copy	NOUN
fnp-4366	273	4	number	number	NOUN
fnp-4366	273	5	alterations	alteration	NOUN
fnp-4366	273	6	were	be	AUX
fnp-4366	273	7	detectable	detectable	ADJ
fnp-4366	273	8	.	.	PUNCT
fnp-4366	274	1	ongoing	ongoing	ADJ
fnp-4366	274	2	molecular	molecular	ADJ
fnp-4366	274	3	analyses	analysis	NOUN
fnp-4366	274	4	will	will	AUX
fnp-4366	274	5	provide	provide	VERB
fnp-4366	274	6	additional	additional	ADJ
fnp-4366	274	7	insight	insight	NOUN
fnp-4366	274	8	in	in	ADP
fnp-4366	274	9	the	the	DET
fnp-4366	274	10	pathogenesis	pathogenesis	NOUN
fnp-4366	274	11	of	of	ADP
fnp-4366	274	12	erbb2	erbb2	ADJ
fnp-4366	274	13	-	-	PUNCT
fnp-4366	274	14	mutant	mutant	ADJ
fnp-4366	274	15	nsts	nst	NOUN
fnp-4366	274	16	.	.	PUNCT
fnp-4366	275	1	conclusion	conclusion	NOUN
fnp-4366	275	2	:	:	PUNCT
fnp-4366	275	3	erbb2	erbb2	ADJ
fnp-4366	275	4	mutations	mutation	NOUN
fnp-4366	275	5	in	in	ADP
fnp-4366	275	6	nst	nst	ADP
fnp-4366	275	7	do	do	AUX
fnp-4366	275	8	not	not	PART
fnp-4366	275	9	occur	occur	VERB
fnp-4366	275	10	as	as	ADP
fnp-4366	275	11	isolated	isolated	ADJ
fnp-4366	275	12	somatic	somatic	ADJ
fnp-4366	275	13	events	event	NOUN
fnp-4366	275	14	in	in	ADP
fnp-4366	275	15	sporadic	sporadic	ADJ
fnp-4366	275	16	tumorigenesis	tumorigenesis	NOUN
fnp-4366	275	17	or	or	CCONJ
fnp-4366	275	18	in	in	ADP
fnp-4366	275	19	the	the	DET
fnp-4366	275	20	setting	setting	NOUN
fnp-4366	275	21	of	of	ADP
fnp-4366	275	22	nf1	nf1	NOUN
fnp-4366	275	23	,	,	PUNCT
fnp-4366	275	24	nf2	nf2	ADJ
fnp-4366	275	25	or	or	CCONJ
fnp-4366	275	26	schwannomatosis	schwannomatosis	NOUN
fnp-4366	275	27	but	but	CCONJ
fnp-4366	275	28	represent	represent	VERB
fnp-4366	275	29	manifestations	manifestation	NOUN
fnp-4366	275	30	of	of	ADP
fnp-4366	275	31	a	a	DET
fnp-4366	275	32	distinct	distinct	ADJ
fnp-4366	275	33	tumor	tumor	NOUN
fnp-4366	275	34	syndrome	syndrome	NOUN
fnp-4366	275	35	most	most	ADV
fnp-4366	275	36	likely	likely	ADV
fnp-4366	275	37	caused	cause	VERB
fnp-4366	275	38	by	by	ADP
fnp-4366	275	39	postzygotic	postzygotic	ADJ
fnp-4366	275	40	erbb2	erbb2	PROPN
fnp-4366	275	41	-	-	PUNCT
fnp-4366	275	42	mosaicism	mosaicism	NOUN
fnp-4366	275	43	.	.	PUNCT
fnp-4366	276	1	diagnosis	diagnosis	NOUN
fnp-4366	276	2	of	of	ADP
fnp-4366	276	3	erbb2	erbb2	ADJ
fnp-4366	276	4	-	-	PUNCT
fnp-4366	276	5	mutant	mutant	ADJ
fnp-4366	276	6	nst	nst	NOUN
fnp-4366	276	7	is	be	AUX
fnp-4366	276	8	of	of	ADP
fnp-4366	276	9	high	high	ADJ
fnp-4366	276	10	clinical	clinical	ADJ
fnp-4366	276	11	relevance	relevance	NOUN
fnp-4366	276	12	due	due	ADP
fnp-4366	276	13	to	to	ADP
fnp-4366	276	14	the	the	DET
fnp-4366	276	15	availability	availability	NOUN
fnp-4366	276	16	of	of	ADP
fnp-4366	276	17	specific	specific	ADJ
fnp-4366	276	18	erbb2	erbb2	ADJ
fnp-4366	276	19	inhibitors	inhibitor	NOUN
fnp-4366	276	20	and	and	CCONJ
fnp-4366	276	21	preliminary	preliminary	ADJ
fnp-4366	276	22	evidence	evidence	NOUN
fnp-4366	276	23	of	of	ADP
fnp-4366	276	24	their	their	PRON
fnp-4366	276	25	effectiveness	effectiveness	NOUN
fnp-4366	276	26	.	.	PUNCT
fnp-4366	277	1	histology	histology	NOUN
fnp-4366	277	2	is	be	AUX
fnp-4366	277	3	sufficiently	sufficiently	ADV
fnp-4366	277	4	specific	specific	ADJ
fnp-4366	277	5	for	for	ADP
fnp-4366	277	6	screening	screen	VERB
fnp-4366	277	7	purposes	purpose	NOUN
fnp-4366	277	8	but	but	CCONJ
fnp-4366	277	9	molecular	molecular	ADJ
fnp-4366	277	10	analyses	analysis	NOUN
fnp-4366	277	11	with	with	ADP
fnp-4366	277	12	highly	highly	ADV
fnp-4366	277	13	sensitive	sensitive	ADJ
fnp-4366	277	14	methods	method	NOUN
fnp-4366	277	15	like	like	ADP
fnp-4366	277	16	deep	deep	ADJ
fnp-4366	277	17	coverage	coverage	NOUN
fnp-4366	277	18	ngs	ng	NOUN
fnp-4366	277	19	are	be	AUX
fnp-4366	277	20	mandatory	mandatory	ADJ
fnp-4366	277	21	for	for	ADP
fnp-4366	277	22	the	the	DET
fnp-4366	277	23	definitive	definitive	ADJ
fnp-4366	277	24	diagnosis	diagnosis	NOUN
fnp-4366	277	25	.	.	PUNCT
fnp-4366	277	26	  	  	SPACE
fnp-4366	277	27	2.09	2.09	NUM
fnp-4366	277	28	free	free	ADJ
fnp-4366	277	29	neuropathol	neuropathol	NOUN
fnp-4366	277	30	3:20:31	3:20:31	NUM
fnp-4366	277	31	cns	cns	NOUN
fnp-4366	277	32	-	-	PUNCT
fnp-4366	277	33	tumor	tumor	NOUN
fnp-4366	277	34	patients	patient	NOUN
fnp-4366	277	35	within	within	ADP
fnp-4366	277	36	the	the	DET
fnp-4366	277	37	impress	impress	NOUN
fnp-4366	277	38	-	-	PUNCT
fnp-4366	277	39	norway	norway	NOUN
fnp-4366	277	40	trial	trial	NOUN
fnp-4366	277	41	:	:	PUNCT
fnp-4366	277	42	first	first	ADJ
fnp-4366	277	43	year	year	NOUN
fnp-4366	277	44	experiences	experience	NOUN
fnp-4366	277	45	pitt	pitt	NOUN
fnp-4366	277	46	niehusmann1,2	niehusmann1,2	PROPN
fnp-4366	277	47	,	,	PUNCT
fnp-4366	277	48	hege	hege	NOUN
fnp-4366	277	49	g	g	PROPN
fnp-4366	277	50	russnes1,3,4	russnes1,3,4	ADJ
fnp-4366	277	51	,	,	PUNCT
fnp-4366	277	52	katarina	katarina	PROPN
fnp-4366	277	53	puco2	puco2	PROPN
fnp-4366	277	54	,	,	PUNCT
fnp-4366	277	55	åsmund	åsmund	ADJ
fnp-4366	277	56	flobak5,6	flobak5,6	PROPN
fnp-4366	277	57	,	,	PUNCT
fnp-4366	277	58	eli	eli	PROPN
fnp-4366	277	59	sihn	sihn	PROPN
fnp-4366	277	60	s.	s.	PROPN
fnp-4366	277	61	steinskog7	steinskog7	PROPN
fnp-4366	277	62	,	,	PUNCT
fnp-4366	277	63	åse	åse	PROPN
fnp-4366	277	64	haug7	haug7	PROPN
fnp-4366	277	65	,	,	PUNCT
fnp-4366	277	66	sigmund	sigmund	PROPN
fnp-4366	277	67	brabrand2,8	brabrand2,8	PROPN
fnp-4366	277	68	,	,	PUNCT
fnp-4366	277	69	egil	egil	PROPN
fnp-4366	277	70	s.	s.	PROPN
fnp-4366	277	71	blix9,10	blix9,10	PROPN
fnp-4366	277	72	,	,	PUNCT
fnp-4366	277	73	anne	anne	PROPN
fnp-4366	277	74	j	j	PROPN
fnp-4366	277	75	skjulsvik5,11	skjulsvik5,11	PROPN
fnp-4366	277	76	,	,	PUNCT
fnp-4366	277	77	ragnhild	ragnhild	NOUN
fnp-4366	277	78	m	m	PROPN
fnp-4366	277	79	wold12	wold12	NOUN
fnp-4366	277	80	,	,	PUNCT
fnp-4366	277	81	henning	henning	PROPN
fnp-4366	277	82	leske1	leske1	PROPN
fnp-4366	277	83	,	,	PUNCT
fnp-4366	277	84	hrvoje	hrvoje	VERB
fnp-4366	277	85	miletic13,14	miletic13,14	PROPN
fnp-4366	277	86	,	,	PUNCT
fnp-4366	277	87	petter	petter	PROPN
fnp-4366	277	88	brandal8,15	brandal8,15	PROPN
fnp-4366	277	89	,	,	PUNCT
fnp-4366	277	90	gro	gro	PROPN
fnp-4366	277	91	l.	l.	PROPN
fnp-4366	277	92	fagereng16	fagereng16	PROPN
fnp-4366	277	93	,	,	PUNCT
fnp-4366	277	94	kjetil	kjetil	PROPN
fnp-4366	277	95	taskén3,17	taskén3,17	PROPN
fnp-4366	277	96	,	,	PUNCT
fnp-4366	277	97	åslaug	åslaug	PROPN
fnp-4366	277	98	helland3,4,8	helland3,4,8	PROPN
fnp-4366	277	99	1	1	NUM
fnp-4366	277	100	oslo	oslo	PROPN
fnp-4366	277	101	university	university	NOUN
fnp-4366	277	102	hospital	hospital	NOUN
fnp-4366	277	103	,	,	PUNCT
fnp-4366	277	104	department	department	NOUN
fnp-4366	277	105	of	of	ADP
fnp-4366	277	106	pathology	pathology	PROPN
fnp-4366	277	107	,	,	PUNCT
fnp-4366	277	108	oslo	oslo	PROPN
fnp-4366	277	109	,	,	PUNCT
fnp-4366	277	110	norway	norway	PROPN
fnp-4366	277	111	2	2	NUM
fnp-4366	277	112	oslo	oslo	PROPN
fnp-4366	277	113	university	university	NOUN
fnp-4366	277	114	hospital	hospital	NOUN
fnp-4366	277	115	,	,	PUNCT
fnp-4366	277	116	division	division	NOUN
fnp-4366	277	117	for	for	ADP
fnp-4366	277	118	cancer	cancer	NOUN
fnp-4366	277	119	medicine	medicine	NOUN
fnp-4366	277	120	,	,	PUNCT
fnp-4366	277	121	oslo	oslo	PROPN
fnp-4366	277	122	,	,	PUNCT
fnp-4366	277	123	norway	norway	PROPN
fnp-4366	277	124	3	3	NUM
fnp-4366	277	125	university	university	PROPN
fnp-4366	277	126	of	of	ADP
fnp-4366	277	127	oslo	oslo	PROPN
fnp-4366	277	128	,	,	PUNCT
fnp-4366	277	129	institute	institute	NOUN
fnp-4366	277	130	of	of	ADP
fnp-4366	277	131	clinical	clinical	ADJ
fnp-4366	277	132	medicine	medicine	NOUN
fnp-4366	277	133	,	,	PUNCT
fnp-4366	277	134	oslo	oslo	PROPN
fnp-4366	277	135	,	,	PUNCT
fnp-4366	277	136	norway	norway	PROPN
fnp-4366	277	137	4	4	NUM
fnp-4366	277	138	oslo	oslo	PROPN
fnp-4366	277	139	university	university	NOUN
fnp-4366	277	140	hospital	hospital	NOUN
fnp-4366	277	141	,	,	PUNCT
fnp-4366	277	142	department	department	NOUN
fnp-4366	277	143	of	of	ADP
fnp-4366	277	144	cancer	cancer	NOUN
fnp-4366	277	145	genetics	genetics	PROPN
fnp-4366	277	146	,	,	PUNCT
fnp-4366	277	147	institute	institute	NOUN
fnp-4366	277	148	for	for	ADP
fnp-4366	277	149	cancer	cancer	NOUN
fnp-4366	277	150	research	research	NOUN
fnp-4366	277	151	,	,	PUNCT
fnp-4366	277	152	oslo	oslo	PROPN
fnp-4366	277	153	,	,	PUNCT
fnp-4366	277	154	norway	norway	PROPN
fnp-4366	277	155	5	5	NUM
fnp-4366	277	156	norwegian	norwegian	PROPN
fnp-4366	277	157	university	university	NOUN
fnp-4366	277	158	of	of	ADP
fnp-4366	277	159	science	science	NOUN
fnp-4366	277	160	and	and	CCONJ
fnp-4366	277	161	technology	technology	NOUN
fnp-4366	277	162	,	,	PUNCT
fnp-4366	277	163	department	department	NOUN
fnp-4366	277	164	of	of	ADP
fnp-4366	277	165	clinical	clinical	ADJ
fnp-4366	277	166	and	and	CCONJ
fnp-4366	277	167	molecular	molecular	ADJ
fnp-4366	277	168	medicine	medicine	NOUN
fnp-4366	277	169	,	,	PUNCT
fnp-4366	277	170	trondheim	trondheim	PROPN
fnp-4366	277	171	,	,	PUNCT
fnp-4366	277	172	norway	norway	PROPN
fnp-4366	277	173	6	6	NUM
fnp-4366	277	174	st	st	PROPN
fnp-4366	277	175	.	.	PROPN
fnp-4366	277	176	olav	olav	PROPN
fnp-4366	277	177	university	university	PROPN
fnp-4366	277	178	hospital	hospital	NOUN
fnp-4366	277	179	,	,	PUNCT
fnp-4366	277	180	the	the	DET
fnp-4366	277	181	cancer	cancer	NOUN
fnp-4366	277	182	clinic	clinic	NOUN
fnp-4366	277	183	,	,	PUNCT
fnp-4366	277	184	trondheim	trondheim	PROPN
fnp-4366	277	185	,	,	PUNCT
fnp-4366	277	186	norway	norway	PROPN
fnp-4366	277	187	7	7	NUM
fnp-4366	277	188	haukeland	haukeland	PROPN
fnp-4366	277	189	university	university	NOUN
fnp-4366	277	190	hospital	hospital	NOUN
fnp-4366	277	191	,	,	PUNCT
fnp-4366	277	192	department	department	NOUN
fnp-4366	277	193	of	of	ADP
fnp-4366	277	194	oncology	oncology	NOUN
fnp-4366	277	195	,	,	PUNCT
fnp-4366	277	196	bergen	bergen	PROPN
fnp-4366	277	197	,	,	PUNCT
fnp-4366	277	198	norway	norway	PROPN
fnp-4366	277	199	8	8	NUM
fnp-4366	277	200	oslo	oslo	PROPN
fnp-4366	277	201	university	university	PROPN
fnp-4366	277	202	hospital	hospital	NOUN
fnp-4366	277	203	,	,	PUNCT
fnp-4366	277	204	department	department	NOUN
fnp-4366	277	205	of	of	ADP
fnp-4366	277	206	oncology	oncology	NOUN
fnp-4366	277	207	,	,	PUNCT
fnp-4366	277	208	oslo	oslo	PROPN
fnp-4366	277	209	,	,	PUNCT
fnp-4366	277	210	norway	norway	PROPN
fnp-4366	277	211	9	9	NUM
fnp-4366	277	212	uit	uit	VERB
fnp-4366	277	213	the	the	DET
fnp-4366	277	214	arctic	arctic	PROPN
fnp-4366	277	215	university	university	PROPN
fnp-4366	277	216	of	of	ADP
fnp-4366	277	217	norway	norway	PROPN
fnp-4366	277	218	,	,	PUNCT
fnp-4366	277	219	institute	institute	NOUN
fnp-4366	277	220	of	of	ADP
fnp-4366	277	221	clinical	clinical	ADJ
fnp-4366	277	222	medicine	medicine	NOUN
fnp-4366	277	223	,	,	PUNCT
fnp-4366	277	224	tromsø	tromsø	PROPN
fnp-4366	277	225	,	,	PUNCT
fnp-4366	277	226	norway	norway	PROPN
fnp-4366	277	227	10	10	NUM
fnp-4366	277	228	university	university	NOUN
fnp-4366	277	229	hospital	hospital	NOUN
fnp-4366	277	230	of	of	ADP
fnp-4366	277	231	north	north	PROPN
fnp-4366	277	232	norway	norway	PROPN
fnp-4366	277	233	,	,	PUNCT
fnp-4366	277	234	department	department	NOUN
fnp-4366	277	235	of	of	ADP
fnp-4366	277	236	oncology	oncology	NOUN
fnp-4366	277	237	,	,	PUNCT
fnp-4366	277	238	tromsø	tromsø	PROPN
fnp-4366	277	239	,	,	PUNCT
fnp-4366	277	240	norway	norway	PROPN
fnp-4366	277	241	11	11	NUM
fnp-4366	277	242	st	st	PROPN
fnp-4366	277	243	.	.	PROPN
fnp-4366	277	244	olav	olav	PROPN
fnp-4366	277	245	university	university	PROPN
fnp-4366	277	246	hospital	hospital	NOUN
fnp-4366	277	247	,	,	PUNCT
fnp-4366	277	248	department	department	NOUN
fnp-4366	277	249	of	of	ADP
fnp-4366	277	250	pathology	pathology	PROPN
fnp-4366	277	251	,	,	PUNCT
fnp-4366	277	252	trondheim	trondheim	PROPN
fnp-4366	277	253	,	,	PUNCT
fnp-4366	277	254	norway	norway	PROPN
fnp-4366	277	255	12	12	NUM
fnp-4366	277	256	university	university	NOUN
fnp-4366	277	257	hospital	hospital	NOUN
fnp-4366	277	258	of	of	ADP
fnp-4366	277	259	north	north	PROPN
fnp-4366	277	260	norway	norway	PROPN
fnp-4366	277	261	,	,	PUNCT
fnp-4366	277	262	department	department	NOUN
fnp-4366	277	263	of	of	ADP
fnp-4366	277	264	pathology	pathology	PROPN
fnp-4366	277	265	,	,	PUNCT
fnp-4366	277	266	tromsø	tromsø	PROPN
fnp-4366	277	267	,	,	PUNCT
fnp-4366	277	268	norway	norway	PROPN
fnp-4366	277	269	13	13	NUM
fnp-4366	277	270	university	university	PROPN
fnp-4366	277	271	of	of	ADP
fnp-4366	277	272	bergen	bergen	PROPN
fnp-4366	277	273	,	,	PUNCT
fnp-4366	277	274	department	department	NOUN
fnp-4366	277	275	of	of	ADP
fnp-4366	277	276	biomedicine	biomedicine	NOUN
fnp-4366	277	277	,	,	PUNCT
fnp-4366	277	278	bergen	bergen	PROPN
fnp-4366	277	279	,	,	PUNCT
fnp-4366	277	280	norway	norway	PROPN
fnp-4366	277	281	14	14	NUM
fnp-4366	277	282	haukeland	haukeland	PROPN
fnp-4366	277	283	university	university	NOUN
fnp-4366	277	284	hospital	hospital	NOUN
fnp-4366	277	285	,	,	PUNCT
fnp-4366	277	286	department	department	NOUN
fnp-4366	277	287	of	of	ADP
fnp-4366	277	288	pathology	pathology	PROPN
fnp-4366	277	289	,	,	PUNCT
fnp-4366	277	290	bergen	bergen	PROPN
fnp-4366	277	291	,	,	PUNCT
fnp-4366	277	292	norway	norway	PROPN
fnp-4366	277	293	15	15	NUM
fnp-4366	277	294	oslo	oslo	PROPN
fnp-4366	277	295	university	university	PROPN
fnp-4366	277	296	hospital	hospital	NOUN
fnp-4366	277	297	,	,	PUNCT
fnp-4366	277	298	section	section	NOUN
fnp-4366	277	299	for	for	ADP
fnp-4366	277	300	cancer	cancer	NOUN
fnp-4366	277	301	cytogenetics	cytogenetic	NOUN
fnp-4366	277	302	,	,	PUNCT
fnp-4366	277	303	institute	institute	NOUN
fnp-4366	277	304	for	for	ADP
fnp-4366	277	305	cancer	cancer	NOUN
fnp-4366	277	306	genetics	genetic	NOUN
fnp-4366	277	307	and	and	CCONJ
fnp-4366	277	308	informatics	informatics	PROPN
fnp-4366	277	309	,	,	PUNCT
fnp-4366	277	310	oslo	oslo	PROPN
fnp-4366	277	311	,	,	PUNCT
fnp-4366	277	312	norway	norway	PROPN
fnp-4366	277	313	16	16	NUM
fnp-4366	277	314	oslo	oslo	PROPN
fnp-4366	277	315	university	university	PROPN
fnp-4366	277	316	hospital	hospital	NOUN
fnp-4366	277	317	,	,	PUNCT
fnp-4366	277	318	institute	institute	NOUN
fnp-4366	277	319	for	for	ADP
fnp-4366	277	320	cancer	cancer	NOUN
fnp-4366	277	321	research	research	NOUN
fnp-4366	277	322	,	,	PUNCT
fnp-4366	277	323	oslo	oslo	PROPN
fnp-4366	277	324	,	,	PUNCT
fnp-4366	277	325	norway	norway	PROPN
fnp-4366	277	326	17	17	NUM
fnp-4366	277	327	oslo	oslo	PROPN
fnp-4366	277	328	university	university	PROPN
fnp-4366	277	329	hospital	hospital	NOUN
fnp-4366	277	330	,	,	PUNCT
fnp-4366	277	331	department	department	NOUN
fnp-4366	277	332	of	of	ADP
fnp-4366	277	333	cancer	cancer	NOUN
fnp-4366	277	334	immunology	immunology	NOUN
fnp-4366	277	335	,	,	PUNCT
fnp-4366	277	336	institute	institute	NOUN
fnp-4366	277	337	for	for	ADP
fnp-4366	277	338	cancer	cancer	NOUN
fnp-4366	277	339	research	research	NOUN
fnp-4366	277	340	,	,	PUNCT
fnp-4366	277	341	oslo	oslo	PROPN
fnp-4366	277	342	,	,	PUNCT
fnp-4366	277	343	norway	norway	PROPN
fnp-4366	277	344	background	background	NOUN
fnp-4366	277	345	:	:	PUNCT
fnp-4366	277	346	impress	impress	NOUN
fnp-4366	277	347	-	-	PUNCT
fnp-4366	277	348	norway	norway	NOUN
fnp-4366	277	349	is	be	AUX
fnp-4366	277	350	a	a	DET
fnp-4366	277	351	nation	nation	NOUN
fnp-4366	277	352	-	-	PUNCT
fnp-4366	277	353	wide	wide	ADJ
fnp-4366	277	354	precision	precision	NOUN
fnp-4366	277	355	medicine	medicine	NOUN
fnp-4366	277	356	trial	trial	NOUN
fnp-4366	277	357	for	for	ADP
fnp-4366	277	358	cancer	cancer	NOUN
fnp-4366	277	359	patients	patient	NOUN
fnp-4366	277	360	in	in	ADP
fnp-4366	277	361	norway	norway	PROPN
fnp-4366	277	362	that	that	PRON
fnp-4366	277	363	launched	launch	VERB
fnp-4366	277	364	april	april	PROPN
fnp-4366	277	365	1st	1st	NOUN
fnp-4366	277	366	2021	2021	NUM
fnp-4366	277	367	.	.	PUNCT
fnp-4366	278	1	in	in	ADP
fnp-4366	278	2	this	this	DET
fnp-4366	278	3	investigator	investigator	NOUN
fnp-4366	278	4	-	-	PUNCT
fnp-4366	278	5	initiated	initiate	VERB
fnp-4366	278	6	,	,	PUNCT
fnp-4366	278	7	prospective	prospective	ADJ
fnp-4366	278	8	,	,	PUNCT
fnp-4366	278	9	open	open	ADJ
fnp-4366	278	10	-	-	PUNCT
fnp-4366	278	11	label	label	NOUN
fnp-4366	278	12	,	,	PUNCT
fnp-4366	278	13	non	non	ADJ
fnp-4366	278	14	-	-	ADJ
fnp-4366	278	15	randomized	randomized	ADJ
fnp-4366	278	16	combined	combine	VERB
fnp-4366	278	17	basketand	basketand	NOUN
fnp-4366	278	18	umbrella	umbrella	NOUN
fnp-4366	278	19	-	-	PUNCT
fnp-4366	278	20	trial	trial	NOUN
fnp-4366	278	21	,	,	PUNCT
fnp-4366	278	22	patients	patient	NOUN
fnp-4366	278	23	are	be	AUX
fnp-4366	278	24	enrolled	enrol	VERB
fnp-4366	278	25	into	into	ADP
fnp-4366	278	26	multiple	multiple	ADJ
fnp-4366	278	27	parallel	parallel	ADJ
fnp-4366	278	28	treatment	treatment	NOUN
fnp-4366	278	29	cohorts	cohort	NOUN
fnp-4366	278	30	.	.	PUNCT
fnp-4366	279	1	patients	patient	NOUN
fnp-4366	279	2	with	with	ADP
fnp-4366	279	3	progressive	progressive	ADJ
fnp-4366	279	4	cancer	cancer	NOUN
fnp-4366	279	5	disease	disease	NOUN
fnp-4366	279	6	,	,	PUNCT
fnp-4366	279	7	including	include	VERB
fnp-4366	279	8	primary	primary	ADJ
fnp-4366	279	9	cns	cns	NOUN
fnp-4366	279	10	-	-	PUNCT
fnp-4366	279	11	neoplasms	neoplasms	NOUN
fnp-4366	279	12	,	,	PUNCT
fnp-4366	279	13	with	with	ADP
fnp-4366	279	14	no	no	DET
fnp-4366	279	15	further	further	ADJ
fnp-4366	279	16	standard	standard	ADJ
fnp-4366	279	17	therapy	therapy	NOUN
fnp-4366	279	18	to	to	PART
fnp-4366	279	19	offer	offer	VERB
fnp-4366	279	20	,	,	PUNCT
fnp-4366	279	21	are	be	AUX
fnp-4366	279	22	eligible	eligible	ADJ
fnp-4366	279	23	.	.	PUNCT
fnp-4366	280	1	all	all	DET
fnp-4366	280	2	drugs	drug	NOUN
fnp-4366	280	3	available	available	ADJ
fnp-4366	280	4	in	in	ADP
fnp-4366	280	5	impress	impress	NOUN
fnp-4366	280	6	-	-	PUNCT
fnp-4366	280	7	norway	norway	NOUN
fnp-4366	280	8	are	be	AUX
fnp-4366	280	9	regulatory	regulatory	ADJ
fnp-4366	280	10	approved	approve	VERB
fnp-4366	280	11	.	.	PUNCT
fnp-4366	281	1	currently	currently	ADV
fnp-4366	281	2	,	,	PUNCT
fnp-4366	281	3	five	five	NUM
fnp-4366	281	4	different	different	ADJ
fnp-4366	281	5	pharmaceutical	pharmaceutical	ADJ
fnp-4366	281	6	companies	company	NOUN
fnp-4366	281	7	provide	provide	VERB
fnp-4366	281	8	16	16	NUM
fnp-4366	281	9	drugs	drug	NOUN
fnp-4366	281	10	,	,	PUNCT
fnp-4366	281	11	and	and	CCONJ
fnp-4366	281	12	we	we	PRON
fnp-4366	281	13	are	be	AUX
fnp-4366	281	14	in	in	ADP
fnp-4366	281	15	process	process	NOUN
fnp-4366	281	16	to	to	PART
fnp-4366	281	17	acquire	acquire	VERB
fnp-4366	281	18	eight	eight	NUM
fnp-4366	281	19	additional	additional	ADJ
fnp-4366	281	20	drugs	drug	NOUN
fnp-4366	281	21	for	for	ADP
fnp-4366	281	22	patients	patient	NOUN
fnp-4366	281	23	in	in	ADP
fnp-4366	281	24	this	this	DET
fnp-4366	281	25	study	study	NOUN
fnp-4366	281	26	.	.	PUNCT
fnp-4366	282	1	methods	method	NOUN
fnp-4366	282	2	:	:	PUNCT
fnp-4366	282	3	comprehensive	comprehensive	ADJ
fnp-4366	282	4	genomic	genomic	NOUN
fnp-4366	282	5	profiling	profiling	NOUN
fnp-4366	282	6	(	(	PUNCT
fnp-4366	282	7	gene	gene	NOUN
fnp-4366	282	8	-	-	PUNCT
fnp-4366	282	9	panel	panel	NOUN
fnp-4366	282	10	analysis	analysis	NOUN
fnp-4366	282	11	of	of	ADP
fnp-4366	282	12	>	>	SYM
fnp-4366	282	13	500	500	NUM
fnp-4366	282	14	genes	gene	NOUN
fnp-4366	282	15	)	)	PUNCT
fnp-4366	282	16	is	be	AUX
fnp-4366	282	17	performed	perform	VERB
fnp-4366	282	18	as	as	ADP
fnp-4366	282	19	part	part	NOUN
fnp-4366	282	20	of	of	ADP
fnp-4366	282	21	the	the	DET
fnp-4366	282	22	norwegian	norwegian	ADJ
fnp-4366	282	23	public	public	ADJ
fnp-4366	282	24	health	health	NOUN
fnp-4366	282	25	care	care	NOUN
fnp-4366	282	26	system	system	NOUN
fnp-4366	282	27	.	.	PUNCT
fnp-4366	283	1	patients	patient	NOUN
fnp-4366	283	2	consenting	consent	VERB
fnp-4366	283	3	to	to	ADP
fnp-4366	283	4	the	the	DET
fnp-4366	283	5	impress	impress	NOUN
fnp-4366	283	6	-	-	PUNCT
fnp-4366	283	7	norway	norway	NOUN
fnp-4366	283	8	profiling	profiling	NOUN
fnp-4366	283	9	phase	phase	NOUN
fnp-4366	283	10	contribute	contribute	VERB
fnp-4366	283	11	their	their	PRON
fnp-4366	283	12	clinical	clinical	ADJ
fnp-4366	283	13	and	and	CCONJ
fnp-4366	283	14	molecular	molecular	ADJ
fnp-4366	283	15	data	datum	NOUN
fnp-4366	283	16	for	for	ADP
fnp-4366	283	17	research	research	NOUN
fnp-4366	283	18	and	and	CCONJ
fnp-4366	283	19	are	be	AUX
fnp-4366	283	20	screened	screen	VERB
fnp-4366	283	21	for	for	ADP
fnp-4366	283	22	cell	cell	NOUN
fnp-4366	283	23	-	-	PUNCT
fnp-4366	283	24	free	free	ADJ
fnp-4366	283	25	circulating	circulate	VERB
fnp-4366	283	26	tumor	tumor	NOUN
fnp-4366	283	27	dna	dna	PROPN
fnp-4366	283	28	.	.	PUNCT
fnp-4366	284	1	patients	patient	NOUN
fnp-4366	284	2	with	with	ADP
fnp-4366	284	3	identified	identify	VERB
fnp-4366	284	4	biomarkers	biomarker	NOUN
fnp-4366	284	5	matching	match	VERB
fnp-4366	284	6	available	available	ADJ
fnp-4366	284	7	drugs	drug	NOUN
fnp-4366	284	8	are	be	AUX
fnp-4366	284	9	referred	refer	VERB
fnp-4366	284	10	by	by	ADP
fnp-4366	284	11	the	the	DET
fnp-4366	284	12	national	national	PROPN
fnp-4366	284	13	molecular	molecular	ADJ
fnp-4366	284	14	tumor	tumor	NOUN
fnp-4366	284	15	board	board	NOUN
fnp-4366	284	16	for	for	ADP
fnp-4366	284	17	inclusion	inclusion	NOUN
fnp-4366	284	18	in	in	ADP
fnp-4366	284	19	the	the	DET
fnp-4366	284	20	impress	impress	NOUN
fnp-4366	284	21	-	-	PUNCT
fnp-4366	284	22	norway	norway	NOUN
fnp-4366	284	23	treatment	treatment	NOUN
fnp-4366	284	24	phase	phase	NOUN
fnp-4366	284	25	.	.	PUNCT
fnp-4366	285	1	these	these	DET
fnp-4366	285	2	patients	patient	NOUN
fnp-4366	285	3	will	will	AUX
fnp-4366	285	4	have	have	VERB
fnp-4366	285	5	extensive	extensive	ADJ
fnp-4366	285	6	biobanking	biobanking	NOUN
fnp-4366	285	7	as	as	ADV
fnp-4366	285	8	well	well	ADV
fnp-4366	285	9	as	as	ADP
fnp-4366	285	10	whole	whole	ADJ
fnp-4366	285	11	genome	genome	NOUN
fnp-4366	285	12	molecular	molecular	ADJ
fnp-4366	285	13	profiling	profiling	NOUN
fnp-4366	285	14	of	of	ADP
fnp-4366	285	15	their	their	PRON
fnp-4366	285	16	tumors	tumor	NOUN
fnp-4366	285	17	before	before	ADP
fnp-4366	285	18	and	and	CCONJ
fnp-4366	285	19	during	during	ADP
fnp-4366	285	20	treatment	treatment	NOUN
fnp-4366	285	21	.	.	PUNCT
fnp-4366	286	1	in	in	ADP
fnp-4366	286	2	the	the	DET
fnp-4366	286	3	impress	impress	NOUN
fnp-4366	286	4	-	-	PUNCT
fnp-4366	286	5	norway	norway	NOUN
fnp-4366	286	6	treatment	treatment	NOUN
fnp-4366	286	7	phase	phase	NOUN
fnp-4366	286	8	,	,	PUNCT
fnp-4366	286	9	each	each	DET
fnp-4366	286	10	cohort	cohort	NOUN
fnp-4366	286	11	is	be	AUX
fnp-4366	286	12	defined	define	VERB
fnp-4366	286	13	by	by	ADP
fnp-4366	286	14	the	the	DET
fnp-4366	286	15	patients	patient	NOUN
fnp-4366	286	16	’	’	PART
fnp-4366	286	17	tumor	tumor	NOUN
fnp-4366	286	18	type	type	NOUN
fnp-4366	286	19	,	,	PUNCT
fnp-4366	286	20	molecular	molecular	ADJ
fnp-4366	286	21	profile	profile	NOUN
fnp-4366	286	22	of	of	ADP
fnp-4366	286	23	the	the	DET
fnp-4366	286	24	tumor	tumor	NOUN
fnp-4366	286	25	,	,	PUNCT
fnp-4366	286	26	and	and	CCONJ
fnp-4366	286	27	study	study	NOUN
fnp-4366	286	28	drug	drug	NOUN
fnp-4366	286	29	.	.	PUNCT
fnp-4366	287	1	treatment	treatment	NOUN
fnp-4366	287	2	outcome	outcome	NOUN
fnp-4366	287	3	in	in	ADP
fnp-4366	287	4	each	each	DET
fnp-4366	287	5	cohort	cohort	NOUN
fnp-4366	287	6	is	be	AUX
fnp-4366	287	7	monitored	monitor	VERB
fnp-4366	287	8	using	use	VERB
fnp-4366	287	9	a	a	DET
fnp-4366	287	10	simon	simon	PROPN
fnp-4366	287	11	two	two	NUM
fnp-4366	287	12	-	-	PUNCT
fnp-4366	287	13	stage	stage	NOUN
fnp-4366	287	14	-	-	PUNCT
fnp-4366	287	15	like	like	ADJ
fnp-4366	287	16	‘	'	PUNCT
fnp-4366	287	17	admissible	admissible	ADJ
fnp-4366	287	18	’	'	PUNCT
fnp-4366	287	19	monitoring	monitoring	NOUN
fnp-4366	287	20	plan	plan	NOUN
fnp-4366	287	21	to	to	PART
fnp-4366	287	22	identify	identify	VERB
fnp-4366	287	23	evidence	evidence	NOUN
fnp-4366	287	24	of	of	ADP
fnp-4366	287	25	clinical	clinical	ADJ
fnp-4366	287	26	activity	activity	NOUN
fnp-4366	287	27	.	.	PUNCT
fnp-4366	288	1	the	the	DET
fnp-4366	288	2	primary	primary	ADJ
fnp-4366	288	3	objective	objective	NOUN
fnp-4366	288	4	in	in	ADP
fnp-4366	288	5	the	the	DET
fnp-4366	288	6	study	study	NOUN
fnp-4366	288	7	is	be	AUX
fnp-4366	288	8	clinical	clinical	ADJ
fnp-4366	288	9	benefit	benefit	NOUN
fnp-4366	288	10	of	of	ADP
fnp-4366	288	11	treatment	treatment	NOUN
fnp-4366	288	12	at	at	ADP
fnp-4366	288	13	16	16	NUM
fnp-4366	288	14	weeks	week	NOUN
fnp-4366	288	15	of	of	ADP
fnp-4366	288	16	treatment	treatment	NOUN
fnp-4366	288	17	;	;	PUNCT
fnp-4366	288	18	defined	define	VERB
fnp-4366	288	19	as	as	ADP
fnp-4366	288	20	complete	complete	ADJ
fnp-4366	288	21	response	response	NOUN
fnp-4366	288	22	,	,	PUNCT
fnp-4366	288	23	partial	partial	ADJ
fnp-4366	288	24	response	response	NOUN
fnp-4366	288	25	,	,	PUNCT
fnp-4366	288	26	or	or	CCONJ
fnp-4366	288	27	stable	stable	ADJ
fnp-4366	288	28	disease	disease	NOUN
fnp-4366	288	29	.	.	PUNCT
fnp-4366	289	1	here	here	ADV
fnp-4366	289	2	,	,	PUNCT
fnp-4366	289	3	we	we	PRON
fnp-4366	289	4	report	report	VERB
fnp-4366	289	5	on	on	ADP
fnp-4366	289	6	patients	patient	NOUN
fnp-4366	289	7	with	with	ADP
fnp-4366	289	8	cns	cns	NOUN
fnp-4366	289	9	-	-	PUNCT
fnp-4366	289	10	neoplasms	neoplasm	NOUN
fnp-4366	289	11	included	include	VERB
fnp-4366	289	12	in	in	ADP
fnp-4366	289	13	the	the	DET
fnp-4366	289	14	impress	impress	NOUN
fnp-4366	289	15	-	-	PUNCT
fnp-4366	289	16	norway	norway	NOUN
fnp-4366	289	17	profiling	profiling	NOUN
fnp-4366	289	18	and	and	CCONJ
fnp-4366	289	19	treatment	treatment	NOUN
fnp-4366	289	20	phases	phase	NOUN
fnp-4366	289	21	.	.	PUNCT
fnp-4366	290	1	results	result	NOUN
fnp-4366	290	2	:	:	PUNCT
fnp-4366	290	3	as	as	ADP
fnp-4366	290	4	of	of	ADP
fnp-4366	290	5	april	april	PROPN
fnp-4366	290	6	30th	30th	NUM
fnp-4366	290	7	,	,	PUNCT
fnp-4366	290	8	2022	2022	NUM
fnp-4366	290	9	,	,	PUNCT
fnp-4366	290	10	twenty	twenty	NUM
fnp-4366	290	11	-	-	PUNCT
fnp-4366	290	12	four	four	NUM
fnp-4366	290	13	patients	patient	NOUN
fnp-4366	290	14	with	with	ADP
fnp-4366	290	15	cns	cns	NOUN
fnp-4366	290	16	-	-	PUNCT
fnp-4366	290	17	neoplasms	neoplasm	NOUN
fnp-4366	290	18	had	have	AUX
fnp-4366	290	19	been	be	AUX
fnp-4366	290	20	included	include	VERB
fnp-4366	290	21	in	in	ADP
fnp-4366	290	22	the	the	DET
fnp-4366	290	23	molecular	molecular	ADJ
fnp-4366	290	24	profiling	profiling	NOUN
fnp-4366	290	25	phase	phase	NOUN
fnp-4366	290	26	of	of	ADP
fnp-4366	290	27	impress	impress	NOUN
fnp-4366	290	28	-	-	PUNCT
fnp-4366	290	29	norway	norway	NOUN
fnp-4366	290	30	and	and	CCONJ
fnp-4366	290	31	22	22	NUM
fnp-4366	290	32	had	have	AUX
fnp-4366	290	33	completed	complete	VERB
fnp-4366	290	34	evaluation	evaluation	NOUN
fnp-4366	290	35	at	at	ADP
fnp-4366	290	36	the	the	DET
fnp-4366	290	37	molecular	molecular	ADJ
fnp-4366	290	38	tumor	tumor	NOUN
fnp-4366	290	39	board	board	NOUN
fnp-4366	290	40	(	(	PUNCT
fnp-4366	290	41	see	see	VERB
fnp-4366	290	42	table	table	NOUN
fnp-4366	290	43	1	1	NUM
fnp-4366	290	44	)	)	PUNCT
fnp-4366	290	45	.	.	PUNCT
fnp-4366	291	1	tumor	tumor	NOUN
fnp-4366	291	2	mutation	mutation	NOUN
fnp-4366	291	3	burden	burden	NOUN
fnp-4366	291	4	(	(	PUNCT
fnp-4366	291	5	tmb	tmb	NOUN
fnp-4366	291	6	)	)	PUNCT
fnp-4366	291	7	in	in	ADP
fnp-4366	291	8	cns	cns	NOUN
fnp-4366	291	9	-	-	PUNCT
fnp-4366	291	10	tumor	tumor	NOUN
fnp-4366	291	11	tissue	tissue	NOUN
fnp-4366	291	12	samples	sample	NOUN
fnp-4366	291	13	ranged	range	VERB
fnp-4366	291	14	from	from	ADP
fnp-4366	291	15	1.6	1.6	NUM
fnp-4366	291	16	-	-	SYM
fnp-4366	291	17	250	250	NUM
fnp-4366	291	18	somatic	somatic	ADJ
fnp-4366	291	19	mutations	mutation	NOUN
fnp-4366	291	20	per	per	ADP
fnp-4366	291	21	megabase	megabase	NOUN
fnp-4366	291	22	(	(	PUNCT
fnp-4366	291	23	mut	mut	PROPN
fnp-4366	291	24	/	/	SYM
fnp-4366	291	25	mb	mb	PROPN
fnp-4366	291	26	;	;	PUNCT
fnp-4366	291	27	median=4.7	median=4.7	NOUN
fnp-4366	291	28	,	,	PUNCT
fnp-4366	291	29	n=23	n=23	PROPN
fnp-4366	291	30	)	)	PUNCT
fnp-4366	291	31	.	.	PUNCT
fnp-4366	292	1	in	in	ADP
fnp-4366	292	2	liquid	liquid	ADJ
fnp-4366	292	3	biopsies	biopsy	NOUN
fnp-4366	292	4	,	,	PUNCT
fnp-4366	292	5	blood	blood	NOUN
fnp-4366	292	6	tmb	tmb	NOUN
fnp-4366	292	7	ranged	range	VERB
fnp-4366	292	8	from	from	ADP
fnp-4366	292	9	0	0	NUM
fnp-4366	292	10	-	-	SYM
fnp-4366	292	11	6	6	NUM
fnp-4366	292	12	mut	mut	NOUN
fnp-4366	292	13	/	/	SYM
fnp-4366	292	14	mb	mb	PROPN
fnp-4366	292	15	(	(	PUNCT
fnp-4366	292	16	median=0	median=0	PROPN
fnp-4366	292	17	;	;	PUNCT
fnp-4366	292	18	n=21	n=21	PROPN
fnp-4366	292	19	)	)	PUNCT
fnp-4366	292	20	,	,	PUNCT
fnp-4366	292	21	indicating	indicate	VERB
fnp-4366	292	22	a	a	DET
fnp-4366	292	23	limited	limited	ADJ
fnp-4366	292	24	efficacy	efficacy	NOUN
fnp-4366	292	25	of	of	ADP
fnp-4366	292	26	this	this	DET
fnp-4366	292	27	analysis	analysis	NOUN
fnp-4366	292	28	in	in	ADP
fnp-4366	292	29	cns	cns	NOUN
fnp-4366	292	30	-	-	PUNCT
fnp-4366	292	31	tumor	tumor	NOUN
fnp-4366	292	32	patients	patient	NOUN
fnp-4366	292	33	.	.	PUNCT
fnp-4366	293	1	in	in	ADP
fnp-4366	293	2	five	five	NUM
fnp-4366	293	3	of	of	ADP
fnp-4366	293	4	the	the	DET
fnp-4366	293	5	22	22	NUM
fnp-4366	293	6	patients	patient	NOUN
fnp-4366	293	7	with	with	ADP
fnp-4366	293	8	completed	complete	VERB
fnp-4366	293	9	evaluation	evaluation	NOUN
fnp-4366	293	10	,	,	PUNCT
fnp-4366	293	11	we	we	PRON
fnp-4366	293	12	identified	identify	VERB
fnp-4366	293	13	biomarker	biomarker	NOUN
fnp-4366	293	14	,	,	PUNCT
fnp-4366	293	15	which	which	PRON
fnp-4366	293	16	allowed	allow	VERB
fnp-4366	293	17	allocation	allocation	NOUN
fnp-4366	293	18	to	to	ADP
fnp-4366	293	19	an	an	DET
fnp-4366	293	20	impress	impress	NOUN
fnp-4366	293	21	-	-	PUNCT
fnp-4366	293	22	norway	norway	NOUN
fnp-4366	293	23	treatment	treatment	NOUN
fnp-4366	293	24	-	-	PUNCT
fnp-4366	293	25	cohort	cohort	NOUN
fnp-4366	293	26	(	(	PUNCT
fnp-4366	293	27	ratio	ratio	NOUN
fnp-4366	293	28	of	of	ADP
fnp-4366	293	29	cns	cns	NOUN
fnp-4366	293	30	-	-	PUNCT
fnp-4366	293	31	patients	patient	NOUN
fnp-4366	293	32	with	with	ADP
fnp-4366	293	33	targetable	targetable	ADJ
fnp-4366	293	34	biomarker	biomarker	NOUN
fnp-4366	293	35	was	be	AUX
fnp-4366	293	36	similar	similar	ADJ
fnp-4366	293	37	to	to	ADP
fnp-4366	293	38	the	the	DET
fnp-4366	293	39	overall	overall	ADJ
fnp-4366	293	40	inclusion	inclusion	NOUN
fnp-4366	293	41	of	of	ADP
fnp-4366	293	42	patients	patient	NOUN
fnp-4366	293	43	into	into	ADP
fnp-4366	293	44	treatment	treatment	NOUN
fnp-4366	293	45	cohorts	cohort	NOUN
fnp-4366	293	46	,	,	PUNCT
fnp-4366	293	47	67/295	67/295	NUM
fnp-4366	293	48	)	)	PUNCT
fnp-4366	293	49	.	.	PUNCT
fnp-4366	294	1	one	one	NUM
fnp-4366	294	2	glioblastoma	glioblastoma	NOUN
fnp-4366	294	3	patient	patient	NOUN
fnp-4366	294	4	showed	show	VERB
fnp-4366	294	5	complete	complete	ADJ
fnp-4366	294	6	response	response	NOUN
fnp-4366	294	7	according	accord	VERB
fnp-4366	294	8	to	to	ADP
fnp-4366	294	9	rano	rano	PROPN
fnp-4366	294	10	at	at	ADP
fnp-4366	294	11	39	39	NUM
fnp-4366	294	12	weeks	week	NOUN
fnp-4366	294	13	.	.	PUNCT
fnp-4366	294	14	  	  	SPACE
fnp-4366	295	1	table	table	NOUN
fnp-4366	295	2	1	1	NUM
fnp-4366	295	3	diagnosis	diagnosis	NOUN
fnp-4366	295	4	treatment	treatment	NOUN
fnp-4366	295	5	cohort	cohort	NOUN
fnp-4366	295	6	glioblastoma	glioblastoma	NOUN
fnp-4366	295	7	,	,	PUNCT
fnp-4366	295	8	idh	idh	NOUN
fnp-4366	295	9	-	-	PUNCT
fnp-4366	295	10	wildtype	wildtype	NOUN
fnp-4366	295	11	(	(	PUNCT
fnp-4366	295	12	n=13	n=13	NOUN
fnp-4366	295	13	)	)	PUNCT
fnp-4366	295	14	n=3	n=3	NOUN
fnp-4366	295	15	astrocytoma	astrocytoma	NOUN
fnp-4366	295	16	,	,	PUNCT
fnp-4366	295	17	idh	idh	NOUN
fnp-4366	295	18	-	-	PUNCT
fnp-4366	295	19	mutant	mutant	NOUN
fnp-4366	295	20	(	(	PUNCT
fnp-4366	295	21	n=4	n=4	NOUN
fnp-4366	295	22	)	)	PUNCT
fnp-4366	295	23	n=0	n=0	NUM
fnp-4366	295	24	anaplastic	anaplastic	ADJ
fnp-4366	295	25	meningioma	meningioma	NOUN
fnp-4366	295	26	(	(	PUNCT
fnp-4366	295	27	n=1	n=1	NOUN
fnp-4366	295	28	)	)	PUNCT
fnp-4366	295	29	n=0	n=0	NUM
fnp-4366	295	30	atypical	atypical	ADJ
fnp-4366	295	31	meningioma	meningioma	NOUN
fnp-4366	295	32	(	(	PUNCT
fnp-4366	295	33	n=1	n=1	PROPN
fnp-4366	295	34	)	)	PUNCT
fnp-4366	295	35	n=0	n=0	PUNCT
fnp-4366	295	36	diffuse	diffuse	VERB
fnp-4366	295	37	midline	midline	NOUN
fnp-4366	295	38	glioma	glioma	NOUN
fnp-4366	295	39	,	,	PUNCT
fnp-4366	295	40	h3	h3	VERB
fnp-4366	295	41	k27	k27	NOUN
fnp-4366	295	42	-	-	PUNCT
fnp-4366	295	43	altered	alter	VERB
fnp-4366	295	44	(	(	PUNCT
fnp-4366	295	45	n=1	n=1	PROPN
fnp-4366	295	46	)	)	PUNCT
fnp-4366	295	47	n=1	n=1	PROPN
fnp-4366	295	48	high	high	ADJ
fnp-4366	295	49	-	-	PUNCT
fnp-4366	295	50	grade	grade	NOUN
fnp-4366	295	51	astrocytoma	astrocytoma	NOUN
fnp-4366	295	52	with	with	ADP
fnp-4366	295	53	piloid	piloid	PROPN
fnp-4366	295	54	features	feature	NOUN
fnp-4366	295	55	(	(	PUNCT
fnp-4366	295	56	n=1	n=1	PROPN
fnp-4366	295	57	)	)	PUNCT
fnp-4366	295	58	n=1	n=1	PROPN
fnp-4366	295	59	myxopapillary	myxopapillary	ADJ
fnp-4366	295	60	ependymoma	ependymoma	NOUN
fnp-4366	295	61	(	(	PUNCT
fnp-4366	295	62	n=2	n=2	NOUN
fnp-4366	295	63	)	)	PUNCT
fnp-4366	295	64	n=0	n=0	PRON
fnp-4366	295	65	supratentorial	supratentorial	ADJ
fnp-4366	295	66	ependymoma	ependymoma	NOUN
fnp-4366	295	67	(	(	PUNCT
fnp-4366	295	68	n=1	n=1	PROPN
fnp-4366	295	69	)	)	PUNCT
fnp-4366	295	70	n=0	n=0	NUM
fnp-4366	295	71	  	  	SPACE
fnp-4366	295	72	due	due	ADP
fnp-4366	295	73	to	to	ADP
fnp-4366	295	74	increasing	increase	VERB
fnp-4366	295	75	test	test	NOUN
fnp-4366	295	76	capacity	capacity	NOUN
fnp-4366	295	77	,	,	PUNCT
fnp-4366	295	78	we	we	PRON
fnp-4366	295	79	anticipate	anticipate	VERB
fnp-4366	295	80	to	to	PART
fnp-4366	295	81	double	double	VERB
fnp-4366	295	82	the	the	DET
fnp-4366	295	83	number	number	NOUN
fnp-4366	295	84	of	of	ADP
fnp-4366	295	85	included	include	VERB
fnp-4366	295	86	cns	cns	NOUN
fnp-4366	295	87	-	-	PUNCT
fnp-4366	295	88	tumor	tumor	NOUN
fnp-4366	295	89	patients	patient	NOUN
fnp-4366	295	90	within	within	ADP
fnp-4366	295	91	the	the	DET
fnp-4366	295	92	next	next	ADJ
fnp-4366	295	93	6	6	NUM
fnp-4366	295	94	months	month	NOUN
fnp-4366	295	95	.	.	PUNCT
fnp-4366	296	1	whole	whole	ADJ
fnp-4366	296	2	genome	genome	NOUN
fnp-4366	296	3	sequencing	sequence	VERB
fnp-4366	296	4	data	datum	NOUN
fnp-4366	296	5	from	from	ADP
fnp-4366	296	6	patients	patient	NOUN
fnp-4366	296	7	included	include	VERB
fnp-4366	296	8	into	into	ADP
fnp-4366	296	9	the	the	DET
fnp-4366	296	10	treatment	treatment	NOUN
fnp-4366	296	11	cohorts	cohort	NOUN
fnp-4366	296	12	are	be	AUX
fnp-4366	296	13	obtained	obtain	VERB
fnp-4366	296	14	successively	successively	ADV
fnp-4366	296	15	.	.	PUNCT
fnp-4366	297	1	conclusion	conclusion	NOUN
fnp-4366	297	2	:	:	PUNCT
fnp-4366	297	3	patients	patient	NOUN
fnp-4366	297	4	with	with	ADP
fnp-4366	297	5	advanced	advanced	ADJ
fnp-4366	297	6	cancer	cancer	NOUN
fnp-4366	297	7	progressing	progressing	NOUN
fnp-4366	297	8	on	on	ADP
fnp-4366	297	9	standard	standard	ADJ
fnp-4366	297	10	treatment	treatment	NOUN
fnp-4366	297	11	are	be	AUX
fnp-4366	297	12	referred	refer	VERB
fnp-4366	297	13	to	to	ADP
fnp-4366	297	14	treatment	treatment	NOUN
fnp-4366	297	15	in	in	ADP
fnp-4366	297	16	impress	impress	NOUN
fnp-4366	297	17	-	-	PUNCT
fnp-4366	297	18	norway	norway	NOUN
fnp-4366	297	19	after	after	ADP
fnp-4366	297	20	advanced	advanced	ADJ
fnp-4366	297	21	molecular	molecular	ADJ
fnp-4366	297	22	diagnostics	diagnostic	NOUN
fnp-4366	297	23	.	.	PUNCT
fnp-4366	298	1	molecular	molecular	ADJ
fnp-4366	298	2	alterations	alteration	NOUN
fnp-4366	298	3	indicating	indicate	VERB
fnp-4366	298	4	benefit	benefit	NOUN
fnp-4366	298	5	of	of	ADP
fnp-4366	298	6	drugs	drug	NOUN
fnp-4366	298	7	currently	currently	ADV
fnp-4366	298	8	available	available	ADJ
fnp-4366	298	9	in	in	ADP
fnp-4366	298	10	the	the	DET
fnp-4366	298	11	study	study	NOUN
fnp-4366	298	12	are	be	AUX
fnp-4366	298	13	detected	detect	VERB
fnp-4366	298	14	in	in	ADP
fnp-4366	298	15	a	a	DET
fnp-4366	298	16	reasonable	reasonable	ADJ
fnp-4366	298	17	number	number	NOUN
fnp-4366	298	18	of	of	ADP
fnp-4366	298	19	patients	patient	NOUN
fnp-4366	298	20	with	with	ADP
fnp-4366	298	21	cns	cns	NOUN
fnp-4366	298	22	-	-	PUNCT
fnp-4366	298	23	neoplasms	neoplasms	NOUN
fnp-4366	298	24	.	.	PUNCT
fnp-4366	298	25	  	  	SPACE
fnp-4366	299	1	3	3	NUM
fnp-4366	299	2	.	.	PUNCT
fnp-4366	299	3	neurodegeneration	neurodegeneration	NOUN
fnp-4366	299	4	3.01	3.01	NUM
fnp-4366	299	5	free	free	ADJ
fnp-4366	299	6	neuropathol	neuropathol	NOUN
fnp-4366	299	7	3:20:33	3:20:33	NUM
fnp-4366	299	8	cnn	cnn	PROPN
fnp-4366	299	9	-	-	PUNCT
fnp-4366	299	10	supported	support	VERB
fnp-4366	299	11	quantification	quantification	NOUN
fnp-4366	299	12	of	of	ADP
fnp-4366	299	13	fat	fat	ADJ
fnp-4366	299	14	compartments	compartment	NOUN
fnp-4366	299	15	at	at	ADP
fnp-4366	299	16	abdominal	abdominal	ADJ
fnp-4366	299	17	mri	mri	NOUN
fnp-4366	299	18	applied	apply	VERB
fnp-4366	299	19	to	to	PART
fnp-4366	299	20	als	als	VERB
fnp-4366	299	21	patients	patient	NOUN
fnp-4366	299	22	ina	ina	PROPN
fnp-4366	299	23	vernikouskaya1	vernikouskaya1	PROPN
fnp-4366	299	24	,	,	PUNCT
fnp-4366	299	25	hans	hans	PROPN
fnp-4366	299	26	-	-	PUNCT
fnp-4366	299	27	peter	peter	PROPN
fnp-4366	299	28	müller2	müller2	PROPN
fnp-4366	299	29	,	,	PUNCT
fnp-4366	299	30	dominik	dominik	PROPN
fnp-4366	299	31	felbel1	felbel1	PROPN
fnp-4366	299	32	,	,	PUNCT
fnp-4366	299	33	francesco	francesco	PROPN
fnp-4366	299	34	roselli2	roselli2	PROPN
fnp-4366	299	35	,	,	PUNCT
fnp-4366	299	36	albert	albert	PROPN
fnp-4366	299	37	christian	christian	PROPN
fnp-4366	299	38	ludolph2	ludolph2	PROPN
fnp-4366	299	39	,	,	PUNCT
fnp-4366	299	40	volker	volker	PROPN
fnp-4366	299	41	rasche1	rasche1	PROPN
fnp-4366	299	42	,	,	PUNCT
fnp-4366	299	43	jan	jan	PROPN
fnp-4366	299	44	kassubek2	kassubek2	PROPN
fnp-4366	299	45	1	1	NUM
fnp-4366	299	46	ulm	ulm	PROPN
fnp-4366	299	47	university	university	PROPN
fnp-4366	299	48	medical	medical	ADJ
fnp-4366	299	49	center	center	NOUN
fnp-4366	299	50	,	,	PUNCT
fnp-4366	299	51	internal	internal	ADJ
fnp-4366	299	52	medicine	medicine	PROPN
fnp-4366	299	53	ii	ii	PROPN
fnp-4366	299	54	,	,	PUNCT
fnp-4366	299	55	ulm	ulm	PROPN
fnp-4366	299	56	,	,	PUNCT
fnp-4366	299	57	deutschland	deutschland	NOUN
fnp-4366	299	58	2	2	NUM
fnp-4366	299	59	university	university	NOUN
fnp-4366	299	60	of	of	ADP
fnp-4366	299	61	ulm	ulm	PROPN
fnp-4366	299	62	,	,	PUNCT
fnp-4366	299	63	neurology	neurology	NOUN
fnp-4366	299	64	,	,	PUNCT
fnp-4366	299	65	ulm	ulm	PROPN
fnp-4366	299	66	,	,	PUNCT
fnp-4366	299	67	deutschland	deutschland	NOUN
fnp-4366	299	68	background	background	NOUN
fnp-4366	299	69	:	:	PUNCT
fnp-4366	299	70	amyotrophic	amyotrophic	ADJ
fnp-4366	299	71	lateral	lateral	ADJ
fnp-4366	299	72	sclerosis	sclerosis	NOUN
fnp-4366	299	73	(	(	PUNCT
fnp-4366	299	74	als	als	NOUN
fnp-4366	299	75	)	)	PUNCT
fnp-4366	299	76	is	be	AUX
fnp-4366	299	77	the	the	DET
fnp-4366	299	78	most	most	ADV
fnp-4366	299	79	frequent	frequent	ADJ
fnp-4366	299	80	adult	adult	NOUN
fnp-4366	299	81	onset	onset	NOUN
fnp-4366	299	82	neurodegenerative	neurodegenerative	ADJ
fnp-4366	299	83	motor	motor	NOUN
fnp-4366	299	84	neuron	neuron	NOUN
fnp-4366	299	85	disease	disease	NOUN
fnp-4366	299	86	characterized	characterize	VERB
fnp-4366	299	87	by	by	ADP
fnp-4366	299	88	catabolism1	catabolism1	PROPN
fnp-4366	299	89	,	,	PUNCT
fnp-4366	299	90	and	and	CCONJ
fnp-4366	299	91	patients	patient	NOUN
fnp-4366	299	92	begin	begin	VERB
fnp-4366	299	93	to	to	PART
fnp-4366	299	94	lose	lose	VERB
fnp-4366	299	95	weight	weight	NOUN
fnp-4366	299	96	more	more	ADJ
fnp-4366	299	97	than	than	ADP
fnp-4366	299	98	10	10	NUM
fnp-4366	299	99	years	year	NOUN
fnp-4366	299	100	before	before	ADP
fnp-4366	299	101	the	the	DET
fnp-4366	299	102	onset	onset	NOUN
fnp-4366	299	103	of	of	ADP
fnp-4366	299	104	motor	motor	PROPN
fnp-4366	299	105	symptoms2	symptoms2	PROPN
fnp-4366	299	106	.	.	PUNCT
fnp-4366	300	1	als	als	NOUN
fnp-4366	300	2	patients	patient	NOUN
fnp-4366	300	3	have	have	AUX
fnp-4366	300	4	been	be	AUX
fnp-4366	300	5	shown	show	VERB
fnp-4366	300	6	to	to	PART
fnp-4366	300	7	display	display	VERB
fnp-4366	300	8	an	an	DET
fnp-4366	300	9	expanded	expand	VERB
fnp-4366	300	10	ratio	ratio	NOUN
fnp-4366	300	11	between	between	ADP
fnp-4366	300	12	visceral	visceral	ADJ
fnp-4366	300	13	adipose	adipose	ADJ
fnp-4366	300	14	tissue	tissue	NOUN
fnp-4366	300	15	(	(	PUNCT
fnp-4366	300	16	vat	vat	NOUN
fnp-4366	300	17	)	)	PUNCT
fnp-4366	300	18	and	and	CCONJ
fnp-4366	300	19	subcutaneous	subcutaneous	ADJ
fnp-4366	300	20	adipose	adipose	ADJ
fnp-4366	300	21	tissue	tissue	NOUN
fnp-4366	300	22	(	(	PUNCT
fnp-4366	300	23	sat)3	sat)3	PROPN
fnp-4366	300	24	.	.	PUNCT
fnp-4366	300	25	accurate	accurate	ADJ
fnp-4366	300	26	segmentation	segmentation	NOUN
fnp-4366	300	27	of	of	ADP
fnp-4366	300	28	body	body	NOUN
fnp-4366	300	29	fat	fat	ADJ
fnp-4366	300	30	compartments	compartment	NOUN
fnp-4366	300	31	from	from	ADP
fnp-4366	300	32	mri	mri	NOUN
fnp-4366	300	33	is	be	AUX
fnp-4366	300	34	,	,	PUNCT
fnp-4366	300	35	however	however	ADV
fnp-4366	300	36	,	,	PUNCT
fnp-4366	300	37	a	a	DET
fnp-4366	300	38	challenging	challenging	ADJ
fnp-4366	300	39	task	task	NOUN
fnp-4366	300	40	due	due	ADP
fnp-4366	300	41	to	to	ADP
fnp-4366	300	42	the	the	DET
fnp-4366	300	43	limited	limited	ADJ
fnp-4366	300	44	reproducibility	reproducibility	NOUN
fnp-4366	300	45	of	of	ADP
fnp-4366	300	46	semi	semi	ADJ
fnp-4366	300	47	-	-	ADJ
fnp-4366	300	48	manual	manual	ADJ
fnp-4366	300	49	delineations	delineation	NOUN
fnp-4366	300	50	and	and	CCONJ
fnp-4366	300	51	artifacts	artifact	NOUN
fnp-4366	300	52	.	.	PUNCT
fnp-4366	301	1	concerning	concern	VERB
fnp-4366	301	2	organ	organ	NOUN
fnp-4366	301	3	segmentation	segmentation	NOUN
fnp-4366	301	4	,	,	PUNCT
fnp-4366	301	5	learning	learning	NOUN
fnp-4366	301	6	-	-	PUNCT
fnp-4366	301	7	based	base	VERB
fnp-4366	301	8	algorithms	algorithm	NOUN
fnp-4366	301	9	and	and	CCONJ
fnp-4366	301	10	especially	especially	ADV
fnp-4366	301	11	convolutional	convolutional	ADJ
fnp-4366	301	12	neural	neural	ADJ
fnp-4366	301	13	networks	network	NOUN
fnp-4366	301	14	(	(	PUNCT
fnp-4366	301	15	cnn	cnn	PROPN
fnp-4366	301	16	)	)	PUNCT
fnp-4366	301	17	have	have	AUX
fnp-4366	301	18	been	be	AUX
fnp-4366	301	19	proven	prove	VERB
fnp-4366	301	20	to	to	PART
fnp-4366	301	21	outperform	outperform	VERB
fnp-4366	301	22	traditional	traditional	ADJ
fnp-4366	301	23	methods	method	NOUN
fnp-4366	301	24	in	in	ADP
fnp-4366	301	25	speed	speed	NOUN
fnp-4366	301	26	and	and	CCONJ
fnp-4366	301	27	reproducibility	reproducibility	NOUN
fnp-4366	301	28	.	.	PUNCT
fnp-4366	302	1	aims	aim	VERB
fnp-4366	302	2	:	:	PUNCT
fnp-4366	302	3	the	the	DET
fnp-4366	302	4	aim	aim	NOUN
fnp-4366	302	5	of	of	ADP
fnp-4366	302	6	this	this	DET
fnp-4366	302	7	study	study	NOUN
fnp-4366	302	8	was	be	AUX
fnp-4366	302	9	to	to	PART
fnp-4366	302	10	automate	automate	VERB
fnp-4366	302	11	the	the	DET
fnp-4366	302	12	discrimination	discrimination	NOUN
fnp-4366	302	13	of	of	ADP
fnp-4366	302	14	abdominal	abdominal	ADJ
fnp-4366	302	15	body	body	NOUN
fnp-4366	302	16	fat	fat	ADJ
fnp-4366	302	17	compartments	compartment	NOUN
fnp-4366	302	18	into	into	ADP
fnp-4366	302	19	sat	sit	VERB
fnp-4366	302	20	and	and	CCONJ
fnp-4366	302	21	vat	vat	NOUN
fnp-4366	302	22	from	from	ADP
fnp-4366	302	23	t1	t1	NOUN
fnp-4366	302	24	-	-	PUNCT
fnp-4366	302	25	weighted	weight	VERB
fnp-4366	302	26	mri	mri	NOUN
fnp-4366	302	27	using	use	VERB
fnp-4366	302	28	deep	deep	ADJ
fnp-4366	302	29	cnn	cnn	PROPN
fnp-4366	302	30	and	and	CCONJ
fnp-4366	302	31	to	to	PART
fnp-4366	302	32	quantify	quantify	VERB
fnp-4366	302	33	the	the	DET
fnp-4366	302	34	fat	fat	ADJ
fnp-4366	302	35	ratio	ratio	NOUN
fnp-4366	302	36	in	in	ADP
fnp-4366	302	37	patients	patient	NOUN
fnp-4366	302	38	with	with	ADP
fnp-4366	302	39	als	als	NOUN
fnp-4366	302	40	as	as	SCONJ
fnp-4366	302	41	compared	compare	VERB
fnp-4366	302	42	to	to	ADP
fnp-4366	302	43	the	the	DET
fnp-4366	302	44	control	control	NOUN
fnp-4366	302	45	cohort	cohort	NOUN
fnp-4366	302	46	.	.	PUNCT
fnp-4366	303	1	question	question	NOUN
fnp-4366	303	2	:	:	PUNCT
fnp-4366	303	3	may	may	AUX
fnp-4366	303	4	cnn	cnn	PROPN
fnp-4366	303	5	-	-	PUNCT
fnp-4366	303	6	supported	support	VERB
fnp-4366	303	7	segmentation	segmentation	NOUN
fnp-4366	303	8	of	of	ADP
fnp-4366	303	9	body	body	NOUN
fnp-4366	303	10	fat	fat	ADJ
fnp-4366	303	11	compartments	compartment	NOUN
fnp-4366	303	12	serve	serve	VERB
fnp-4366	303	13	for	for	ADP
fnp-4366	303	14	unbiased	unbiased	ADJ
fnp-4366	303	15	analysis	analysis	NOUN
fnp-4366	303	16	of	of	ADP
fnp-4366	303	17	the	the	DET
fnp-4366	303	18	vat	vat	NOUN
fnp-4366	303	19	/	/	SYM
fnp-4366	303	20	sat	sit	VERB
fnp-4366	303	21	ratio	ratio	NOUN
fnp-4366	303	22	parameter	parameter	NOUN
fnp-4366	303	23	as	as	ADP
fnp-4366	303	24	a	a	DET
fnp-4366	303	25	potential	potential	ADJ
fnp-4366	303	26	biological	biological	ADJ
fnp-4366	303	27	marker	marker	NOUN
fnp-4366	303	28	?	?	PUNCT
fnp-4366	304	1	methods	method	NOUN
fnp-4366	304	2	:	:	PUNCT
fnp-4366	304	3	74	74	NUM
fnp-4366	304	4	als	als	NOUN
fnp-4366	304	5	patients	patient	NOUN
fnp-4366	304	6	(	(	PUNCT
fnp-4366	304	7	age	age	NOUN
fnp-4366	304	8	60	60	NUM
fnp-4366	304	9	±	±	NUM
fnp-4366	304	10	12	12	NUM
fnp-4366	304	11	,	,	PUNCT
fnp-4366	304	12	m	m	PROPN
fnp-4366	304	13	/	/	SYM
fnp-4366	304	14	f	f	PROPN
fnp-4366	304	15	50/24	50/24	NUM
fnp-4366	304	16	)	)	PUNCT
fnp-4366	304	17	and	and	CCONJ
fnp-4366	304	18	81	81	NUM
fnp-4366	304	19	healthy	healthy	ADJ
fnp-4366	304	20	subjects	subject	NOUN
fnp-4366	304	21	(	(	PUNCT
fnp-4366	304	22	56	56	NUM
fnp-4366	304	23	±	±	NUM
fnp-4366	304	24	15	15	NUM
fnp-4366	304	25	,	,	PUNCT
fnp-4366	304	26	42/39	42/39	NUM
fnp-4366	304	27	)	)	PUNCT
fnp-4366	304	28	underwent	underwent	NOUN
fnp-4366	304	29	mri	mri	NOUN
fnp-4366	304	30	examination	examination	NOUN
fnp-4366	304	31	with	with	ADP
fnp-4366	304	32	multi	multi	ADJ
fnp-4366	304	33	-	-	ADJ
fnp-4366	304	34	slice	slice	ADJ
fnp-4366	304	35	t1	t1	NOUN
fnp-4366	304	36	-	-	PUNCT
fnp-4366	304	37	weighted	weight	VERB
fnp-4366	304	38	spin	spin	NOUN
fnp-4366	304	39	-	-	PUNCT
fnp-4366	304	40	echo	echo	NOUN
fnp-4366	304	41	sequence	sequence	NOUN
fnp-4366	304	42	.	.	PUNCT
fnp-4366	305	1	all	all	DET
fnp-4366	305	2	available	available	ADJ
fnp-4366	305	3	data	datum	NOUN
fnp-4366	305	4	were	be	AUX
fnp-4366	305	5	split	split	VERB
fnp-4366	305	6	in	in	ADP
fnp-4366	305	7	training	training	NOUN
fnp-4366	305	8	(	(	PUNCT
fnp-4366	305	9	50	50	NUM
fnp-4366	305	10	%	%	NOUN
fnp-4366	305	11	)	)	PUNCT
fnp-4366	305	12	,	,	PUNCT
fnp-4366	305	13	validation	validation	NOUN
fnp-4366	305	14	(	(	PUNCT
fnp-4366	305	15	6	6	NUM
fnp-4366	305	16	%	%	NOUN
fnp-4366	305	17	)	)	PUNCT
fnp-4366	305	18	,	,	PUNCT
fnp-4366	305	19	and	and	CCONJ
fnp-4366	305	20	test	test	NOUN
fnp-4366	305	21	(	(	PUNCT
fnp-4366	305	22	44	44	NUM
fnp-4366	305	23	%	%	NOUN
fnp-4366	305	24	)	)	PUNCT
fnp-4366	305	25	data	datum	NOUN
fnp-4366	305	26	,	,	PUNCT
fnp-4366	305	27	based	base	VERB
fnp-4366	305	28	on	on	ADP
fnp-4366	305	29	age	age	NOUN
fnp-4366	305	30	and	and	CCONJ
fnp-4366	305	31	bmi	bmi	VERB
fnp-4366	305	32	strata	strata	PROPN
fnp-4366	305	33	.	.	PUNCT
fnp-4366	306	1	semi	semi	ADJ
fnp-4366	306	2	-	-	ADJ
fnp-4366	306	3	automatic	automatic	ADJ
fnp-4366	306	4	segmentation	segmentation	NOUN
fnp-4366	306	5	of	of	ADP
fnp-4366	306	6	subcutaneous	subcutaneous	ADJ
fnp-4366	306	7	and	and	CCONJ
fnp-4366	306	8	visceral	visceral	ADJ
fnp-4366	306	9	fat	fat	NOUN
fnp-4366	306	10	was	be	AUX
fnp-4366	306	11	performed	perform	VERB
fnp-4366	306	12	with	with	ADP
fnp-4366	306	13	an	an	DET
fnp-4366	306	14	established	establish	VERB
fnp-4366	306	15	reference	reference	NOUN
fnp-4366	306	16	method	method	NOUN
fnp-4366	306	17	using	use	VERB
fnp-4366	306	18	software	software	NOUN
fnp-4366	306	19	package	package	NOUN
fnp-4366	306	20	atlas4	atlas4	PROPN
fnp-4366	306	21	.	.	PUNCT
fnp-4366	307	1	the	the	DET
fnp-4366	307	2	obtained	obtain	VERB
fnp-4366	307	3	sat	sit	VERB
fnp-4366	307	4	/	/	SYM
fnp-4366	307	5	vat	vat	NOUN
fnp-4366	307	6	masks	mask	NOUN
fnp-4366	307	7	were	be	AUX
fnp-4366	307	8	used	use	VERB
fnp-4366	307	9	for	for	ADP
fnp-4366	307	10	training	training	NOUN
fnp-4366	307	11	of	of	ADP
fnp-4366	307	12	the	the	DET
fnp-4366	307	13	cnn	cnn	PROPN
fnp-4366	307	14	of	of	ADP
fnp-4366	307	15	u	u	PROPN
fnp-4366	307	16	-	-	NOUN
fnp-4366	307	17	net	net	ADJ
fnp-4366	307	18	like	like	ADJ
fnp-4366	307	19	architecture	architecture	NOUN
fnp-4366	307	20	.	.	PUNCT
fnp-4366	308	1	performance	performance	NOUN
fnp-4366	308	2	of	of	ADP
fnp-4366	308	3	the	the	DET
fnp-4366	308	4	segmentation	segmentation	NOUN
fnp-4366	308	5	using	use	VERB
fnp-4366	308	6	cnn	cnn	PROPN
fnp-4366	308	7	was	be	AUX
fnp-4366	308	8	evaluated	evaluate	VERB
fnp-4366	308	9	in	in	ADP
fnp-4366	308	10	terms	term	NOUN
fnp-4366	308	11	of	of	ADP
fnp-4366	308	12	dice	dice	NOUN
fnp-4366	308	13	coefficients	coefficient	NOUN
fnp-4366	308	14	.	.	PUNCT
fnp-4366	309	1	volumetric	volumetric	ADJ
fnp-4366	309	2	computation	computation	NOUN
fnp-4366	309	3	of	of	ADP
fnp-4366	309	4	segmented	segmented	PROPN
fnp-4366	309	5	sat	sit	VERB
fnp-4366	309	6	and	and	CCONJ
fnp-4366	309	7	vat	vat	NOUN
fnp-4366	309	8	for	for	ADP
fnp-4366	309	9	all	all	DET
fnp-4366	309	10	test	test	NOUN
fnp-4366	309	11	objects	object	NOUN
fnp-4366	309	12	was	be	AUX
fnp-4366	309	13	performed	perform	VERB
fnp-4366	309	14	with	with	ADP
fnp-4366	309	15	reference	reference	NOUN
fnp-4366	309	16	and	and	CCONJ
fnp-4366	309	17	cnn	cnn	PROPN
fnp-4366	309	18	-	-	PUNCT
fnp-4366	309	19	based	base	VERB
fnp-4366	309	20	methods	method	NOUN
fnp-4366	309	21	and	and	CCONJ
fnp-4366	309	22	compared	compare	VERB
fnp-4366	309	23	by	by	ADP
fnp-4366	309	24	pearson	pearson	PROPN
fnp-4366	309	25	correlation	correlation	NOUN
fnp-4366	309	26	.	.	PUNCT
fnp-4366	310	1	vat	vat	NOUN
fnp-4366	310	2	/	/	SYM
fnp-4366	310	3	sat	sit	VERB
fnp-4366	310	4	ratio	ratio	NOUN
fnp-4366	310	5	was	be	AUX
fnp-4366	310	6	assessed	assess	VERB
fnp-4366	310	7	.	.	PUNCT
fnp-4366	311	1	results	result	NOUN
fnp-4366	311	2	:	:	PUNCT
fnp-4366	311	3	the	the	DET
fnp-4366	311	4	dice	dice	NOUN
fnp-4366	311	5	coefficients	coefficient	NOUN
fnp-4366	311	6	between	between	ADP
fnp-4366	311	7	the	the	DET
fnp-4366	311	8	cnn	cnn	PROPN
fnp-4366	311	9	-	-	PUNCT
fnp-4366	311	10	supported	support	VERB
fnp-4366	311	11	and	and	CCONJ
fnp-4366	311	12	reference	reference	NOUN
fnp-4366	311	13	segmentations	segmentation	NOUN
fnp-4366	311	14	comprised	comprise	VERB
fnp-4366	311	15	0.87	0.87	NUM
fnp-4366	311	16	±	±	NUM
fnp-4366	311	17	0.04	0.04	NUM
fnp-4366	311	18	for	for	ADP
fnp-4366	311	19	sat	sit	VERB
fnp-4366	311	20	and	and	CCONJ
fnp-4366	311	21	0.64	0.64	NUM
fnp-4366	311	22	±	±	NUM
fnp-4366	311	23	0.17	0.17	NUM
fnp-4366	311	24	for	for	ADP
fnp-4366	311	25	vat	vat	NOUN
fnp-4366	311	26	in	in	ADP
fnp-4366	311	27	the	the	DET
fnp-4366	311	28	control	control	NOUN
fnp-4366	311	29	group	group	NOUN
fnp-4366	311	30	and	and	CCONJ
fnp-4366	311	31	0.87	0.87	NUM
fnp-4366	311	32	±	±	NUM
fnp-4366	311	33	0.08	0.08	NUM
fnp-4366	311	34	for	for	ADP
fnp-4366	311	35	sat	sit	VERB
fnp-4366	311	36	and	and	CCONJ
fnp-4366	311	37	0.68	0.68	NUM
fnp-4366	311	38	±	±	NUM
fnp-4366	311	39	0.15	0.15	NUM
fnp-4366	311	40	for	for	ADP
fnp-4366	311	41	vat	vat	NOUN
fnp-4366	311	42	in	in	ADP
fnp-4366	311	43	the	the	DET
fnp-4366	311	44	als	als	NOUN
fnp-4366	311	45	group	group	NOUN
fnp-4366	311	46	.	.	PUNCT
fnp-4366	312	1	a	a	DET
fnp-4366	312	2	significant	significant	ADJ
fnp-4366	312	3	linear	linear	ADJ
fnp-4366	312	4	correlation	correlation	NOUN
fnp-4366	312	5	between	between	ADP
fnp-4366	312	6	the	the	DET
fnp-4366	312	7	cnn	cnn	PROPN
fnp-4366	312	8	predicted	predict	VERB
fnp-4366	312	9	and	and	CCONJ
fnp-4366	312	10	reference	reference	NOUN
fnp-4366	312	11	method	method	NOUN
fnp-4366	312	12	with	with	ADP
fnp-4366	312	13	pearson	pearson	PROPN
fnp-4366	312	14	coefficients	coefficient	VERB
fnp-4366	312	15	0.992	0.992	NUM
fnp-4366	312	16	in	in	ADP
fnp-4366	312	17	controls	control	NOUN
fnp-4366	312	18	and	and	CCONJ
fnp-4366	312	19	0.977	0.977	NUM
fnp-4366	312	20	in	in	ADP
fnp-4366	312	21	als	als	NOUN
fnp-4366	312	22	patients	patient	NOUN
fnp-4366	312	23	was	be	AUX
fnp-4366	312	24	observed	observe	VERB
fnp-4366	312	25	for	for	ADP
fnp-4366	312	26	sat	sit	VERB
fnp-4366	312	27	,	,	PUNCT
fnp-4366	312	28	whereas	whereas	SCONJ
fnp-4366	312	29	lower	low	ADJ
fnp-4366	312	30	pearson	pearson	PROPN
fnp-4366	312	31	coefficients	coefficient	VERB
fnp-4366	312	32	0.653	0.653	NUM
fnp-4366	312	33	in	in	ADP
fnp-4366	312	34	controls	control	NOUN
fnp-4366	312	35	and	and	CCONJ
fnp-4366	312	36	0.814	0.814	NUM
fnp-4366	312	37	in	in	ADP
fnp-4366	312	38	als	als	NOUN
fnp-4366	312	39	patients	patient	NOUN
fnp-4366	312	40	were	be	AUX
fnp-4366	312	41	obtained	obtain	VERB
fnp-4366	312	42	for	for	ADP
fnp-4366	312	43	vat	vat	NOUN
fnp-4366	312	44	.	.	PUNCT
fnp-4366	313	1	significant	significant	ADJ
fnp-4366	313	2	difference	difference	NOUN
fnp-4366	313	3	for	for	ADP
fnp-4366	313	4	the	the	DET
fnp-4366	313	5	vat	vat	NOUN
fnp-4366	313	6	/	/	SYM
fnp-4366	313	7	sat	sit	VERB
fnp-4366	313	8	ratio	ratio	NOUN
fnp-4366	313	9	was	be	AUX
fnp-4366	313	10	observed	observe	VERB
fnp-4366	313	11	when	when	SCONJ
fnp-4366	313	12	comparing	compare	VERB
fnp-4366	313	13	als	als	NOUN
fnp-4366	313	14	patients	patient	NOUN
fnp-4366	313	15	versus	versus	ADP
fnp-4366	313	16	healthy	healthy	ADJ
fnp-4366	313	17	subjects	subject	NOUN
fnp-4366	313	18	with	with	ADP
fnp-4366	313	19	the	the	DET
fnp-4366	313	20	p	p	NOUN
fnp-4366	313	21	-	-	PUNCT
fnp-4366	313	22	value	value	NOUN
fnp-4366	313	23	of	of	ADP
fnp-4366	313	24	0.002	0.002	NUM
fnp-4366	313	25	.	.	PUNCT
fnp-4366	314	1	figure	figure	NOUN
fnp-4366	314	2	1	1	NUM
fnp-4366	314	3	shows	show	VERB
fnp-4366	314	4	the	the	DET
fnp-4366	314	5	sat	sat	NOUN
fnp-4366	314	6	and	and	CCONJ
fnp-4366	314	7	vat	vat	NOUN
fnp-4366	314	8	segmentation	segmentation	NOUN
fnp-4366	314	9	results	result	NOUN
fnp-4366	314	10	in	in	ADP
fnp-4366	314	11	healthy	healthy	ADJ
fnp-4366	314	12	controls	control	NOUN
fnp-4366	314	13	and	and	CCONJ
fnp-4366	314	14	als	als	NOUN
fnp-4366	314	15	patients	patient	NOUN
fnp-4366	314	16	.	.	PUNCT
fnp-4366	315	1	conclusions	conclusion	NOUN
fnp-4366	315	2	:	:	PUNCT
fnp-4366	315	3	the	the	DET
fnp-4366	315	4	obtained	obtain	VERB
fnp-4366	315	5	results	result	NOUN
fnp-4366	315	6	in	in	ADP
fnp-4366	315	7	the	the	DET
fnp-4366	315	8	t1	t1	NOUN
fnp-4366	315	9	-	-	PUNCT
fnp-4366	315	10	weighted	weight	VERB
fnp-4366	315	11	mri	mri	NOUN
fnp-4366	315	12	data	datum	NOUN
fnp-4366	315	13	in	in	ADP
fnp-4366	315	14	the	the	DET
fnp-4366	315	15	als	als	NOUN
fnp-4366	315	16	patient	patient	ADJ
fnp-4366	315	17	cohort	cohort	NOUN
fnp-4366	315	18	could	could	AUX
fnp-4366	315	19	reproduce	reproduce	VERB
fnp-4366	315	20	the	the	DET
fnp-4366	315	21	results	result	NOUN
fnp-4366	315	22	of	of	ADP
fnp-4366	315	23	a	a	DET
fnp-4366	315	24	reference	reference	NOUN
fnp-4366	315	25	technique	technique	NOUN
fnp-4366	315	26	in	in	ADP
fnp-4366	315	27	a	a	DET
fnp-4366	315	28	user	user	NOUN
fnp-4366	315	29	-	-	PUNCT
fnp-4366	315	30	independent	independent	ADJ
fnp-4366	315	31	manner	manner	NOUN
fnp-4366	315	32	with	with	ADP
fnp-4366	315	33	high	high	ADJ
fnp-4366	315	34	accuracy	accuracy	NOUN
fnp-4366	315	35	.	.	PUNCT
fnp-4366	316	1	cnn	cnn	PROPN
fnp-4366	316	2	-	-	PUNCT
fnp-4366	316	3	supported	support	VERB
fnp-4366	316	4	quantification	quantification	NOUN
fnp-4366	316	5	of	of	ADP
fnp-4366	316	6	vat	vat	NOUN
fnp-4366	316	7	/	/	SYM
fnp-4366	316	8	sat	sit	VERB
fnp-4366	316	9	ratio	ratio	NOUN
fnp-4366	316	10	might	might	AUX
fnp-4366	316	11	serve	serve	VERB
fnp-4366	316	12	as	as	ADP
fnp-4366	316	13	a	a	DET
fnp-4366	316	14	biological	biological	ADJ
fnp-4366	316	15	marker	marker	NOUN
fnp-4366	316	16	in	in	ADP
fnp-4366	316	17	als	als	NOUN
fnp-4366	316	18	body	body	NOUN
fnp-4366	316	19	composition	composition	NOUN
fnp-4366	316	20	assessment	assessment	NOUN
fnp-4366	316	21	,	,	PUNCT
fnp-4366	316	22	potentially	potentially	ADV
fnp-4366	316	23	as	as	ADP
fnp-4366	316	24	a	a	DET
fnp-4366	316	25	secondary	secondary	ADJ
fnp-4366	316	26	read	read	NOUN
fnp-4366	316	27	-	-	PUNCT
fnp-4366	316	28	out	out	NOUN
fnp-4366	316	29	for	for	ADP
fnp-4366	316	30	clinical	clinical	ADJ
fnp-4366	316	31	trials	trial	NOUN
fnp-4366	316	32	.	.	PUNCT
fnp-4366	317	1	references	reference	NOUN
fnp-4366	317	2	:	:	PUNCT
fnp-4366	317	3	1	1	X
fnp-4366	317	4	.	.	X
fnp-4366	317	5	dupuis	dupuis	PROPN
fnp-4366	317	6	et	et	PROPN
fnp-4366	317	7	al	al	PROPN
fnp-4366	317	8	,	,	PUNCT
fnp-4366	317	9	lancet	lancet	PROPN
fnp-4366	317	10	neurol	neurol	NOUN
fnp-4366	317	11	.	.	PUNCT
fnp-4366	317	12	2011	2011	NUM
fnp-4366	318	1	2	2	NUM
fnp-4366	318	2	.	.	PUNCT
fnp-4366	318	3	peter	peter	PROPN
fnp-4366	318	4	et	et	PROPN
fnp-4366	318	5	al	al	PROPN
fnp-4366	318	6	,	,	PUNCT
fnp-4366	318	7	eur	eur	PROPN
fnp-4366	318	8	j	j	PROPN
fnp-4366	318	9	epidemiol	epidemiol	PROPN
fnp-4366	318	10	.	.	PROPN
fnp-4366	318	11	2017	2017	NUM
fnp-4366	318	12	3	3	NUM
fnp-4366	318	13	.	.	X
fnp-4366	318	14	lindauer	lindauer	PROPN
fnp-4366	318	15	et	et	PROPN
fnp-4366	318	16	al	al	PROPN
fnp-4366	318	17	,	,	PUNCT
fnp-4366	318	18	plos	plos	PROPN
fnp-4366	318	19	one	one	NUM
fnp-4366	318	20	.	.	PUNCT
fnp-4366	319	1	2013	2013	NUM
fnp-4366	319	2	4	4	NUM
fnp-4366	319	3	.	.	PUNCT
fnp-4366	320	1	müller	müller	PROPN
fnp-4366	320	2	et	et	PROPN
fnp-4366	320	3	al	al	PROPN
fnp-4366	320	4	,	,	PUNCT
fnp-4366	320	5	nmr	nmr	NOUN
fnp-4366	320	6	biomed	biome	VERB
fnp-4366	320	7	.	.	PUNCT
fnp-4366	321	1	2011	2011	NUM
fnp-4366	321	2	figure	figure	NOUN
fnp-4366	321	3	1	1	NUM
fnp-4366	321	4	:	:	PUNCT
fnp-4366	321	5	comparison	comparison	NOUN
fnp-4366	321	6	of	of	ADP
fnp-4366	321	7	ccn	ccn	PROPN
fnp-4366	321	8	-	-	PUNCT
fnp-4366	321	9	based	base	VERB
fnp-4366	321	10	segmentation	segmentation	NOUN
fnp-4366	321	11	vs.	vs.	ADP
fnp-4366	321	12	reference	reference	NOUN
fnp-4366	321	13	segmentation	segmentation	NOUN
fnp-4366	321	14	and	and	CCONJ
fnp-4366	321	15	vat	vat	NOUN
fnp-4366	321	16	/	/	SYM
fnp-4366	321	17	sat	sit	VERB
fnp-4366	321	18	ratio	ratio	NOUN
fnp-4366	321	19	plot	plot	NOUN
fnp-4366	321	20	in	in	ADP
fnp-4366	321	21	healthy	healthy	ADJ
fnp-4366	321	22	controls	control	NOUN
fnp-4366	321	23	and	and	CCONJ
fnp-4366	321	24	als	als	NOUN
fnp-4366	321	25	patients	patient	NOUN
fnp-4366	321	26	.	.	PUNCT
fnp-4366	321	27	  	  	SPACE
fnp-4366	322	1	3.02	3.02	NUM
fnp-4366	322	2	free	free	ADJ
fnp-4366	322	3	neuropathol	neuropathol	NOUN
fnp-4366	322	4	3:20:35	3:20:35	NUM
fnp-4366	322	5	neurodegenerative	neurodegenerative	ADJ
fnp-4366	322	6	iron	iron	NOUN
fnp-4366	322	7	storage	storage	NOUN
fnp-4366	322	8	disease	disease	NOUN
fnp-4366	322	9	(	(	PUNCT
fnp-4366	322	10	neuroferritinopathy	neuroferritinopathy	ADJ
fnp-4366	322	11	)	)	PUNCT
fnp-4366	322	12	caused	cause	VERB
fnp-4366	322	13	by	by	ADP
fnp-4366	322	14	a	a	DET
fnp-4366	322	15	novel	novel	ADJ
fnp-4366	322	16	frameshift	frameshift	NOUN
fnp-4366	322	17	mutation	mutation	NOUN
fnp-4366	322	18	in	in	ADP
fnp-4366	322	19	the	the	DET
fnp-4366	322	20	ferritin	ferritin	ADJ
fnp-4366	322	21	heavy	heavy	ADJ
fnp-4366	322	22	chain	chain	NOUN
fnp-4366	322	23	gene	gene	NOUN
fnp-4366	322	24	(	(	PUNCT
fnp-4366	322	25	fth1	fth1	PROPN
fnp-4366	322	26	c.341	c.341	PROPN
fnp-4366	322	27	-	-	PUNCT
fnp-4366	322	28	342del	342del	NUM
fnp-4366	322	29	)	)	PUNCT
fnp-4366	322	30	vincent	vincent	NOUN
fnp-4366	322	31	umathum1,2	umathum1,2	PROPN
fnp-4366	322	32	,	,	PUNCT
fnp-4366	322	33	daniel	daniel	PROPN
fnp-4366	322	34	amsel1	amsel1	PROPN
fnp-4366	322	35	,	,	PUNCT
fnp-4366	322	36	christina	christina	PROPN
fnp-4366	322	37	becker3	becker3	PROPN
fnp-4366	322	38	,	,	PUNCT
fnp-4366	322	39	corinne	corinne	PROPN
fnp-4366	322	40	kasan3	kasan3	PROPN
fnp-4366	322	41	,	,	PUNCT
fnp-4366	322	42	andrea	andrea	PROPN
fnp-4366	322	43	may4	may4	PROPN
fnp-4366	322	44	,	,	PUNCT
fnp-4366	322	45	klaus	klaus	PROPN
fnp-4366	322	46	nehmer4	nehmer4	PROPN
fnp-4366	322	47	,	,	PUNCT
fnp-4366	322	48	andreas	andreas	PROPN
fnp-4366	322	49	günther4,5	günther4,5	PROPN
fnp-4366	322	50	,	,	PUNCT
fnp-4366	322	51	carmen	carman	NOUN
fnp-4366	322	52	selignow1	selignow1	NOUN
fnp-4366	322	53	,	,	PUNCT
fnp-4366	322	54	anna	anna	PROPN
fnp-4366	322	55	nishimura1	nishimura1	PROPN
fnp-4366	322	56	,	,	PUNCT
fnp-4366	322	57	ioannis	ioannis	PROPN
fnp-4366	322	58	alexopoulos6	alexopoulos6	PROPN
fnp-4366	322	59	,	,	PUNCT
fnp-4366	322	60	attila	attila	PROPN
fnp-4366	322	61	németh1	németh1	PROPN
fnp-4366	322	62	,	,	PUNCT
fnp-4366	322	63	nadja	nadja	PROPN
fnp-4366	322	64	ritschel1	ritschel1	PROPN
fnp-4366	322	65	,	,	PUNCT
fnp-4366	322	66	axel	axel	PROPN
fnp-4366	322	67	weber7	weber7	PROPN
fnp-4366	322	68	,	,	PUNCT
fnp-4366	322	69	till	till	SCONJ
fnp-4366	322	70	acker1	acker1	PROPN
fnp-4366	322	71	,	,	PUNCT
fnp-4366	322	72	anne	anne	PROPN
fnp-4366	322	73	schänzer1	schänzer1	PROPN
fnp-4366	322	74	1	1	NUM
fnp-4366	322	75	institut	institut	PROPN
fnp-4366	322	76	für	für	PROPN
fnp-4366	322	77	neuropathologie	neuropathologie	PROPN
fnp-4366	322	78	,	,	PUNCT
fnp-4366	322	79	justus	justus	PROPN
fnp-4366	322	80	-	-	PUNCT
fnp-4366	322	81	liebig	liebig	NOUN
fnp-4366	322	82	-	-	PUNCT
fnp-4366	322	83	universität	universität	NOUN
fnp-4366	322	84	,	,	PUNCT
fnp-4366	322	85	gießen	gießen	NOUN
fnp-4366	322	86	,	,	PUNCT
fnp-4366	322	87	deutschland	deutschland	NOUN
fnp-4366	322	88	2	2	NUM
fnp-4366	322	89	institut	institut	PROPN
fnp-4366	322	90	für	für	PROPN
fnp-4366	322	91	pathologie	pathologie	PROPN
fnp-4366	322	92	und	und	PROPN
fnp-4366	322	93	molekularpathologie	molekularpathologie	PROPN
fnp-4366	322	94	,	,	PUNCT
fnp-4366	322	95	bundeswehrkrankenhaus	bundeswehrkrankenhaus	PROPN
fnp-4366	322	96	ulm	ulm	PROPN
fnp-4366	322	97	,	,	PUNCT
fnp-4366	322	98	ulm	ulm	PROPN
fnp-4366	322	99	,	,	PUNCT
fnp-4366	322	100	deutschland	deutschland	NOUN
fnp-4366	322	101	3	3	NUM
fnp-4366	322	102	institut	institut	PROPN
fnp-4366	322	103	für	für	PROPN
fnp-4366	322	104	pathologie	pathologie	PROPN
fnp-4366	322	105	,	,	PUNCT
fnp-4366	322	106	zytologie	zytologie	PROPN
fnp-4366	322	107	und	und	VERB
fnp-4366	322	108	molekularpathologie	molekularpathologie	PROPN
fnp-4366	322	109	mvz	mvz	ADJ
fnp-4366	322	110	,	,	PUNCT
fnp-4366	322	111	wetzlar	wetzlar	ADJ
fnp-4366	322	112	,	,	PUNCT
fnp-4366	322	113	deutschland	deutschland	NOUN
fnp-4366	322	114	4	4	NUM
fnp-4366	322	115	pneumologische	pneumologische	NOUN
fnp-4366	322	116	klinik	klinik	PROPN
fnp-4366	322	117	,	,	PUNCT
fnp-4366	322	118	agaplesion	agaplesion	NOUN
fnp-4366	322	119	evangelisches	evangelisches	ADP
fnp-4366	322	120	krankenhaus	krankenhaus	PROPN
fnp-4366	322	121	,	,	PUNCT
fnp-4366	322	122	gießen	gießen	PROPN
fnp-4366	322	123	,	,	PUNCT
fnp-4366	322	124	deutschland	deutschland	NOUN
fnp-4366	322	125	5	5	NUM
fnp-4366	322	126	zentrum	zentrum	AUX
fnp-4366	322	127	für	für	PROPN
fnp-4366	322	128	interstitielle	interstitielle	PROPN
fnp-4366	322	129	und	und	PROPN
fnp-4366	322	130	seltene	seltene	PROPN
fnp-4366	322	131	lungenerkrankungen	lungenerkrankungen	PROPN
fnp-4366	322	132	,	,	PUNCT
fnp-4366	322	133	justus	justus	PROPN
fnp-4366	322	134	-	-	PUNCT
fnp-4366	322	135	liebig	liebig	NOUN
fnp-4366	322	136	-	-	PUNCT
fnp-4366	322	137	universität	universität	NOUN
fnp-4366	322	138	,	,	PUNCT
fnp-4366	322	139	gießen	gießen	NOUN
fnp-4366	322	140	,	,	PUNCT
fnp-4366	322	141	deutschland	deutschland	NOUN
fnp-4366	322	142	6	6	NUM
fnp-4366	322	143	institute	institute	NOUN
fnp-4366	322	144	for	for	ADP
fnp-4366	322	145	lung	lung	NOUN
fnp-4366	322	146	health	health	NOUN
fnp-4366	322	147	,	,	PUNCT
fnp-4366	322	148	justus	justus	PROPN
fnp-4366	322	149	-	-	PUNCT
fnp-4366	322	150	liebig	liebig	NOUN
fnp-4366	322	151	-	-	PUNCT
fnp-4366	322	152	universität	universität	NOUN
fnp-4366	322	153	,	,	PUNCT
fnp-4366	322	154	gießen	gießen	NOUN
fnp-4366	322	155	,	,	PUNCT
fnp-4366	322	156	deutschland	deutschland	NOUN
fnp-4366	322	157	7	7	NUM
fnp-4366	322	158	institut	institut	PROPN
fnp-4366	322	159	für	für	PROPN
fnp-4366	322	160	humangentik	humangentik	PROPN
fnp-4366	322	161	,	,	PUNCT
fnp-4366	322	162	justus	justus	PROPN
fnp-4366	322	163	-	-	PUNCT
fnp-4366	322	164	liebig	liebig	NOUN
fnp-4366	322	165	-	-	PUNCT
fnp-4366	322	166	universität	universität	NOUN
fnp-4366	322	167	,	,	PUNCT
fnp-4366	322	168	gießen	gießen	NOUN
fnp-4366	322	169	,	,	PUNCT
fnp-4366	322	170	deutschland	deutschland	NOUN
fnp-4366	322	171	introduction	introduction	NOUN
fnp-4366	322	172	:	:	PUNCT
fnp-4366	322	173	neuroferritinopathy	neuroferritinopathy	ADJ
fnp-4366	322	174	(	(	PUNCT
fnp-4366	322	175	nf	nf	INTJ
fnp-4366	322	176	)	)	PUNCT
fnp-4366	322	177	is	be	AUX
fnp-4366	322	178	a	a	DET
fnp-4366	322	179	rare	rare	ADJ
fnp-4366	322	180	hereditary	hereditary	ADJ
fnp-4366	322	181	neurodegenerative	neurodegenerative	ADJ
fnp-4366	322	182	disorder	disorder	NOUN
fnp-4366	322	183	associated	associate	VERB
fnp-4366	322	184	with	with	ADP
fnp-4366	322	185	increased	increase	VERB
fnp-4366	322	186	iron	iron	NOUN
fnp-4366	322	187	deposition	deposition	NOUN
fnp-4366	322	188	in	in	ADP
fnp-4366	322	189	the	the	DET
fnp-4366	322	190	brain	brain	NOUN
fnp-4366	322	191	and	and	CCONJ
fnp-4366	322	192	extracerebral	extracerebral	ADJ
fnp-4366	322	193	organs	organ	NOUN
fnp-4366	322	194	such	such	ADJ
fnp-4366	322	195	as	as	ADP
fnp-4366	322	196	the	the	DET
fnp-4366	322	197	kidney	kidney	NOUN
fnp-4366	322	198	,	,	PUNCT
fnp-4366	322	199	liver	liver	NOUN
fnp-4366	322	200	,	,	PUNCT
fnp-4366	322	201	skin	skin	NOUN
fnp-4366	322	202	and	and	CCONJ
fnp-4366	322	203	skeletal	skeletal	ADJ
fnp-4366	322	204	muscle	muscle	NOUN
fnp-4366	322	205	.	.	PUNCT
fnp-4366	323	1	the	the	DET
fnp-4366	323	2	ferritin	ferritin	ADJ
fnp-4366	323	3	complex	complex	ADJ
fnp-4366	323	4	consists	consist	NOUN
fnp-4366	323	5	of	of	ADP
fnp-4366	323	6	24	24	NUM
fnp-4366	323	7	subunits	subunit	NOUN
fnp-4366	323	8	of	of	ADP
fnp-4366	323	9	ferritin	ferritin	ADJ
fnp-4366	323	10	light	light	ADJ
fnp-4366	323	11	and	and	CCONJ
fnp-4366	323	12	heavy	heavy	ADJ
fnp-4366	323	13	chains	chain	NOUN
fnp-4366	323	14	and	and	CCONJ
fnp-4366	323	15	converts	convert	VERB
fnp-4366	323	16	free	free	ADJ
fnp-4366	323	17	iron	iron	NOUN
fnp-4366	323	18	into	into	ADP
fnp-4366	323	19	a	a	DET
fnp-4366	323	20	non	non	ADJ
fnp-4366	323	21	-	-	ADJ
fnp-4366	323	22	redox	redox	ADJ
fnp-4366	323	23	active	active	ADJ
fnp-4366	323	24	storage	storage	NOUN
fnp-4366	323	25	form	form	NOUN
fnp-4366	323	26	.	.	PUNCT
fnp-4366	324	1	clinically	clinically	ADV
fnp-4366	324	2	,	,	PUNCT
fnp-4366	324	3	the	the	DET
fnp-4366	324	4	focus	focus	NOUN
fnp-4366	324	5	is	be	AUX
fnp-4366	324	6	on	on	ADP
fnp-4366	324	7	chorea	chorea	NOUN
fnp-4366	324	8	-	-	PUNCT
fnp-4366	324	9	huntington	huntington	PROPN
fnp-4366	324	10	-	-	PUNCT
fnp-4366	324	11	like	like	ADJ
fnp-4366	324	12	movement	movement	NOUN
fnp-4366	324	13	disorders	disorder	NOUN
fnp-4366	324	14	.	.	PUNCT
fnp-4366	325	1	so	so	ADV
fnp-4366	325	2	far	far	ADV
fnp-4366	325	3	,	,	PUNCT
fnp-4366	325	4	only	only	ADV
fnp-4366	325	5	mutations	mutation	NOUN
fnp-4366	325	6	in	in	ADP
fnp-4366	325	7	the	the	DET
fnp-4366	325	8	ferritin	ferritin	ADJ
fnp-4366	325	9	light	light	ADJ
fnp-4366	325	10	chain	chain	NOUN
fnp-4366	325	11	gene	gene	NOUN
fnp-4366	325	12	(	(	PUNCT
fnp-4366	325	13	ftl	ftl	NOUN
fnp-4366	325	14	)	)	PUNCT
fnp-4366	325	15	have	have	AUX
fnp-4366	325	16	been	be	AUX
fnp-4366	325	17	described	describe	VERB
fnp-4366	325	18	in	in	ADP
fnp-4366	325	19	nf	nf	PROPN
fnp-4366	325	20	.	.	PUNCT
fnp-4366	325	21	material	material	NOUN
fnp-4366	325	22	and	and	CCONJ
fnp-4366	325	23	methods	method	NOUN
fnp-4366	325	24	:	:	PUNCT
fnp-4366	325	25	a	a	DET
fnp-4366	325	26	78	78	NUM
fnp-4366	325	27	-	-	PUNCT
fnp-4366	325	28	year	year	NOUN
fnp-4366	325	29	-	-	PUNCT
fnp-4366	325	30	old	old	ADJ
fnp-4366	325	31	female	female	ADJ
fnp-4366	325	32	patient	patient	NOUN
fnp-4366	325	33	died	die	VERB
fnp-4366	325	34	of	of	ADP
fnp-4366	325	35	covid-19	covid-19	PROPN
fnp-4366	325	36	-	-	PUNCT
fnp-4366	325	37	associated	associate	VERB
fnp-4366	325	38	pneumonia	pneumonia	NOUN
fnp-4366	325	39	and	and	CCONJ
fnp-4366	325	40	was	be	AUX
fnp-4366	325	41	autopsied	autopsie	VERB
fnp-4366	325	42	.	.	PUNCT
fnp-4366	326	1	standard	standard	ADJ
fnp-4366	326	2	staining	stain	VERB
fnp-4366	326	3	(	(	PUNCT
fnp-4366	326	4	he	he	PRON
fnp-4366	326	5	,	,	PUNCT
fnp-4366	326	6	prussian	prussian	ADJ
fnp-4366	326	7	blue	blue	NOUN
fnp-4366	326	8	)	)	PUNCT
fnp-4366	326	9	,	,	PUNCT
fnp-4366	326	10	immunohistochemical	immunohistochemical	ADJ
fnp-4366	326	11	and	and	CCONJ
fnp-4366	326	12	immunofluorescence	immunofluorescence	NOUN
fnp-4366	326	13	staining	stain	VERB
fnp-4366	326	14	as	as	ADV
fnp-4366	326	15	well	well	ADV
fnp-4366	326	16	as	as	ADP
fnp-4366	326	17	electron	electron	NOUN
fnp-4366	326	18	microscopic	microscopic	NOUN
fnp-4366	326	19	analyses	analysis	NOUN
fnp-4366	326	20	were	be	AUX
fnp-4366	326	21	performed	perform	VERB
fnp-4366	326	22	on	on	ADP
fnp-4366	326	23	paraffin	paraffin	NOUN
fnp-4366	326	24	-	-	PUNCT
fnp-4366	326	25	embedded	embed	VERB
fnp-4366	326	26	formalin	formalin	NOUN
fnp-4366	326	27	-	-	PUNCT
fnp-4366	326	28	fixed	fix	VERB
fnp-4366	326	29	(	(	PUNCT
fnp-4366	326	30	ffpe	ffpe	NOUN
fnp-4366	326	31	)	)	PUNCT
fnp-4366	326	32	tissue	tissue	NOUN
fnp-4366	326	33	of	of	ADP
fnp-4366	326	34	the	the	DET
fnp-4366	326	35	patient	patient	NOUN
fnp-4366	326	36	from	from	ADP
fnp-4366	326	37	different	different	ADJ
fnp-4366	326	38	brain	brain	NOUN
fnp-4366	326	39	regions	region	NOUN
fnp-4366	326	40	as	as	ADV
fnp-4366	326	41	well	well	ADV
fnp-4366	326	42	as	as	ADP
fnp-4366	326	43	heart	heart	NOUN
fnp-4366	326	44	,	,	PUNCT
fnp-4366	326	45	lung	lung	NOUN
fnp-4366	326	46	,	,	PUNCT
fnp-4366	326	47	liver	liver	NOUN
fnp-4366	326	48	and	and	CCONJ
fnp-4366	326	49	kidney	kidney	NOUN
fnp-4366	326	50	.	.	PUNCT
fnp-4366	327	1	whole	whole	ADJ
fnp-4366	327	2	slide	slide	NOUN
fnp-4366	327	3	images	image	NOUN
fnp-4366	327	4	scans	scan	NOUN
fnp-4366	327	5	were	be	AUX
fnp-4366	327	6	done	do	VERB
fnp-4366	327	7	by	by	ADP
fnp-4366	327	8	hamamatsu	hamamatsu	NOUN
fnp-4366	327	9	nanozoomer	nanozoomer	NOUN
fnp-4366	327	10	s360	s360	PROPN
fnp-4366	327	11	and	and	CCONJ
fnp-4366	327	12	evaluated	evaluate	VERB
fnp-4366	327	13	morphometrically	morphometrically	ADV
fnp-4366	327	14	with	with	ADP
fnp-4366	327	15	qpath	qpath	NOUN
fnp-4366	327	16	.	.	PUNCT
fnp-4366	328	1	whole	whole	ADJ
fnp-4366	328	2	-	-	PUNCT
fnp-4366	328	3	exome	exome	NOUN
fnp-4366	328	4	sequencing	sequencing	NOUN
fnp-4366	328	5	(	(	PUNCT
fnp-4366	328	6	wes	wes	PROPN
fnp-4366	328	7	)	)	PUNCT
fnp-4366	328	8	was	be	AUX
fnp-4366	328	9	done	do	VERB
fnp-4366	328	10	from	from	ADP
fnp-4366	328	11	ffpe	ffpe	ADJ
fnp-4366	328	12	material	material	NOUN
fnp-4366	328	13	of	of	ADP
fnp-4366	328	14	the	the	DET
fnp-4366	328	15	basal	basal	ADJ
fnp-4366	328	16	ganglia	ganglia	NOUN
fnp-4366	328	17	.	.	PUNCT
fnp-4366	329	1	results	result	NOUN
fnp-4366	329	2	:	:	PUNCT
fnp-4366	329	3	macroscopically	macroscopically	ADV
fnp-4366	329	4	,	,	PUNCT
fnp-4366	329	5	no	no	DET
fnp-4366	329	6	pathology	pathology	NOUN
fnp-4366	329	7	was	be	AUX
fnp-4366	329	8	found	find	VERB
fnp-4366	329	9	in	in	ADP
fnp-4366	329	10	the	the	DET
fnp-4366	329	11	brain	brain	NOUN
fnp-4366	329	12	.	.	PUNCT
fnp-4366	330	1	microscopically	microscopically	ADV
fnp-4366	330	2	,	,	PUNCT
fnp-4366	330	3	numerous	numerous	ADJ
fnp-4366	330	4	inclusion	inclusion	NOUN
fnp-4366	330	5	bodies	body	NOUN
fnp-4366	330	6	(	(	PUNCT
fnp-4366	330	7	ib	ib	NOUN
fnp-4366	330	8	)	)	PUNCT
fnp-4366	330	9	were	be	AUX
fnp-4366	330	10	seen	see	VERB
fnp-4366	330	11	in	in	ADP
fnp-4366	330	12	the	the	DET
fnp-4366	330	13	brain	brain	NOUN
fnp-4366	330	14	and	and	CCONJ
fnp-4366	330	15	sporadically	sporadically	ADV
fnp-4366	330	16	in	in	ADP
fnp-4366	330	17	the	the	DET
fnp-4366	330	18	liver	liver	NOUN
fnp-4366	330	19	and	and	CCONJ
fnp-4366	330	20	kidney	kidney	NOUN
fnp-4366	330	21	.	.	PUNCT
fnp-4366	331	1	the	the	DET
fnp-4366	331	2	ib	ib	PROPN
fnp-4366	331	3	were	be	AUX
fnp-4366	331	4	homogeneously	homogeneously	ADV
fnp-4366	331	5	sharply	sharply	ADV
fnp-4366	331	6	defined	define	VERB
fnp-4366	331	7	on	on	ADP
fnp-4366	331	8	he	he	PRON
fnp-4366	331	9	stains	stain	NOUN
fnp-4366	331	10	and	and	CCONJ
fnp-4366	331	11	up	up	ADP
fnp-4366	331	12	to	to	PART
fnp-4366	331	13	13	13	NUM
fnp-4366	331	14	µm	µm	NOUN
fnp-4366	331	15	in	in	ADP
fnp-4366	331	16	size	size	NOUN
fnp-4366	331	17	(	(	PUNCT
fnp-4366	331	18	normal	normal	ADJ
fnp-4366	331	19	nuclear	nuclear	ADJ
fnp-4366	331	20	diameter	diameter	NOUN
fnp-4366	331	21	:	:	PUNCT
fnp-4366	331	22	approx	approx	PROPN
fnp-4366	331	23	.	.	PUNCT
fnp-4366	332	1	5	5	NUM
fnp-4366	332	2	-	-	SYM
fnp-4366	332	3	6	6	NUM
fnp-4366	332	4	µm	µm	NOUN
fnp-4366	332	5	)	)	PUNCT
fnp-4366	332	6	,	,	PUNCT
fnp-4366	332	7	with	with	ADP
fnp-4366	332	8	strong	strong	ADJ
fnp-4366	332	9	fe3	fe3	NOUN
fnp-4366	332	10	+	+	NUM
fnp-4366	332	11	deposits	deposit	NOUN
fnp-4366	332	12	in	in	ADP
fnp-4366	332	13	the	the	DET
fnp-4366	332	14	prussian	prussian	ADJ
fnp-4366	332	15	blue	blue	ADJ
fnp-4366	332	16	staining	stain	VERB
fnp-4366	332	17	.	.	PUNCT
fnp-4366	333	1	ultrastructurally	ultrastructurally	ADV
fnp-4366	333	2	,	,	PUNCT
fnp-4366	333	3	the	the	DET
fnp-4366	333	4	ib	ib	NOUN
fnp-4366	333	5	showed	show	VERB
fnp-4366	333	6	intranuclear	intranuclear	NOUN
fnp-4366	333	7	,	,	PUNCT
fnp-4366	333	8	fine	fine	ADJ
fnp-4366	333	9	granular	granular	ADJ
fnp-4366	333	10	aggregates	aggregate	NOUN
fnp-4366	333	11	with	with	ADP
fnp-4366	333	12	lateralisation	lateralisation	NOUN
fnp-4366	333	13	of	of	ADP
fnp-4366	333	14	the	the	DET
fnp-4366	333	15	chromatin	chromatin	NOUN
fnp-4366	333	16	to	to	ADP
fnp-4366	333	17	the	the	DET
fnp-4366	333	18	inner	inner	ADJ
fnp-4366	333	19	side	side	NOUN
fnp-4366	333	20	of	of	ADP
fnp-4366	333	21	the	the	DET
fnp-4366	333	22	membrane	membrane	NOUN
fnp-4366	333	23	.	.	PUNCT
fnp-4366	334	1	immunohistochemistry	immunohistochemistry	NOUN
fnp-4366	334	2	for	for	ADP
fnp-4366	334	3	ftl	ftl	NOUN
fnp-4366	334	4	and	and	CCONJ
fnp-4366	334	5	ferritin	ferritin	ADJ
fnp-4366	334	6	heavy	heavy	ADJ
fnp-4366	334	7	chain	chain	NOUN
fnp-4366	334	8	protein	protein	NOUN
fnp-4366	334	9	(	(	PUNCT
fnp-4366	334	10	fth	fth	NOUN
fnp-4366	334	11	)	)	PUNCT
fnp-4366	334	12	showed	show	VERB
fnp-4366	334	13	clear	clear	ADJ
fnp-4366	334	14	nuclear	nuclear	ADJ
fnp-4366	334	15	expression	expression	NOUN
fnp-4366	334	16	in	in	ADP
fnp-4366	334	17	the	the	DET
fnp-4366	334	18	ib	ib	NOUN
fnp-4366	334	19	.	.	PUNCT
fnp-4366	335	1	in	in	ADP
fnp-4366	335	2	contrast	contrast	NOUN
fnp-4366	335	3	,	,	PUNCT
fnp-4366	335	4	the	the	DET
fnp-4366	335	5	cells	cell	NOUN
fnp-4366	335	6	in	in	ADP
fnp-4366	335	7	the	the	DET
fnp-4366	335	8	control	control	NOUN
fnp-4366	335	9	tissue	tissue	NOUN
fnp-4366	335	10	had	have	AUX
fnp-4366	335	11	predominantly	predominantly	ADV
fnp-4366	335	12	perinuclear	perinuclear	ADJ
fnp-4366	335	13	,	,	PUNCT
fnp-4366	335	14	cytoplasmic	cytoplasmic	ADJ
fnp-4366	335	15	expression	expression	NOUN
fnp-4366	335	16	.	.	PUNCT
fnp-4366	336	1	quantitative	quantitative	ADJ
fnp-4366	336	2	evaluation	evaluation	NOUN
fnp-4366	336	3	showed	show	VERB
fnp-4366	336	4	increased	increase	VERB
fnp-4366	336	5	fth	fth	NOUN
fnp-4366	336	6	expression	expression	NOUN
fnp-4366	336	7	in	in	ADP
fnp-4366	336	8	the	the	DET
fnp-4366	336	9	patient	patient	NOUN
fnp-4366	336	10	:	:	PUNCT
fnp-4366	336	11	frontal	frontal	ADJ
fnp-4366	336	12	cortex	cortex	NOUN
fnp-4366	336	13	(	(	PUNCT
fnp-4366	336	14	cf	cf	NOUN
fnp-4366	336	15	):	):	PUNCT
fnp-4366	336	16	0.2	0.2	NUM
fnp-4366	336	17	%	%	NOUN
fnp-4366	336	18	,	,	PUNCT
fnp-4366	336	19	occipital	occipital	ADJ
fnp-4366	336	20	cortex	cortex	NOUN
fnp-4366	336	21	(	(	PUNCT
fnp-4366	336	22	co	co	NOUN
fnp-4366	336	23	):	):	PUNCT
fnp-4366	336	24	0.3	0.3	NUM
fnp-4366	336	25	%	%	NOUN
fnp-4366	336	26	,	,	PUNCT
fnp-4366	336	27	hippocampus	hippocampus	NOUN
fnp-4366	336	28	:	:	PUNCT
fnp-4366	336	29	0.08	0.08	NUM
fnp-4366	336	30	%	%	NOUN
fnp-4366	336	31	,	,	PUNCT
fnp-4366	336	32	basal	basal	ADJ
fnp-4366	336	33	ganglia	ganglia	NOUN
fnp-4366	336	34	(	(	PUNCT
fnp-4366	336	35	bg	bg	NOUN
fnp-4366	336	36	):	):	PUNCT
fnp-4366	336	37	0.7	0.7	NUM
fnp-4366	336	38	%	%	NOUN
fnp-4366	336	39	,	,	PUNCT
fnp-4366	336	40	dentate	dentate	ADJ
fnp-4366	336	41	nucleus	nucleus	NOUN
fnp-4366	336	42	(	(	PUNCT
fnp-4366	336	43	dn	dn	ADJ
fnp-4366	336	44	):	):	PUNCT
fnp-4366	336	45	1.7	1.7	NUM
fnp-4366	336	46	%	%	NOUN
fnp-4366	336	47	compared	compare	VERB
fnp-4366	336	48	to	to	PART
fnp-4366	336	49	control	control	VERB
fnp-4366	336	50	tissue	tissue	NOUN
fnp-4366	336	51	(	(	PUNCT
fnp-4366	336	52	cf	cf	NOUN
fnp-4366	336	53	:	:	PUNCT
fnp-4366	336	54	0.06	0.06	NUM
fnp-4366	336	55	%	%	NOUN
fnp-4366	336	56	co	co	NOUN
fnp-4366	336	57	:	:	PUNCT
fnp-4366	336	58	0.04	0.04	NUM
fnp-4366	336	59	%	%	NOUN
fnp-4366	336	60	hippocampus	hippocampus	NOUN
fnp-4366	336	61	:	:	PUNCT
fnp-4366	336	62	0.04	0.04	NUM
fnp-4366	336	63	%	%	NOUN
fnp-4366	336	64	bg	bg	NOUN
fnp-4366	336	65	:	:	PUNCT
fnp-4366	336	66	0.08	0.08	NUM
fnp-4366	336	67	%	%	NOUN
fnp-4366	336	68	dn	dn	ADP
fnp-4366	336	69	:	:	PUNCT
fnp-4366	336	70	0.4	0.4	NUM
fnp-4366	336	71	%	%	NOUN
fnp-4366	336	72	.	.	PUNCT
fnp-4366	337	1	the	the	DET
fnp-4366	337	2	ratio	ratio	NOUN
fnp-4366	337	3	of	of	ADP
fnp-4366	337	4	fth	fth	NOUN
fnp-4366	337	5	expression	expression	NOUN
fnp-4366	337	6	(	(	PUNCT
fnp-4366	337	7	compared	compare	VERB
fnp-4366	337	8	to	to	ADP
fnp-4366	337	9	control	control	NOUN
fnp-4366	337	10	tissue	tissue	NOUN
fnp-4366	337	11	)	)	PUNCT
fnp-4366	337	12	was	be	AUX
fnp-4366	337	13	highest	high	ADJ
fnp-4366	337	14	in	in	ADP
fnp-4366	337	15	the	the	DET
fnp-4366	337	16	bg	bg	PROPN
fnp-4366	337	17	(	(	PUNCT
fnp-4366	337	18	1:8.4	1:8.4	NUM
fnp-4366	337	19	)	)	PUNCT
fnp-4366	337	20	,	,	PUNCT
fnp-4366	337	21	followed	follow	VERB
fnp-4366	337	22	by	by	ADP
fnp-4366	337	23	the	the	DET
fnp-4366	337	24	co	co	X
fnp-4366	337	25	(	(	PUNCT
fnp-4366	337	26	1:8.3	1:8.3	NUM
fnp-4366	337	27	)	)	PUNCT
fnp-4366	337	28	and	and	CCONJ
fnp-4366	337	29	lowest	low	ADJ
fnp-4366	337	30	in	in	ADP
fnp-4366	337	31	the	the	DET
fnp-4366	337	32	hippocampus	hippocampus	NOUN
fnp-4366	337	33	(	(	PUNCT
fnp-4366	337	34	1:2.1	1:2.1	NUM
fnp-4366	337	35	)	)	PUNCT
fnp-4366	337	36	.	.	PUNCT
fnp-4366	338	1	wes	wes	PROPN
fnp-4366	338	2	revealed	reveal	VERB
fnp-4366	338	3	a	a	DET
fnp-4366	338	4	previously	previously	ADV
fnp-4366	338	5	undescribed	undescribe	VERB
fnp-4366	338	6	variant	variant	NOUN
fnp-4366	338	7	(	(	PUNCT
fnp-4366	338	8	double	double	ADJ
fnp-4366	338	9	deletion	deletion	NOUN
fnp-4366	338	10	)	)	PUNCT
fnp-4366	338	11	in	in	ADP
fnp-4366	338	12	the	the	DET
fnp-4366	338	13	ferritin	ferritin	ADJ
fnp-4366	338	14	heavy	heavy	ADJ
fnp-4366	338	15	chain	chain	NOUN
fnp-4366	338	16	gene	gene	NOUN
fnp-4366	338	17	(	(	PUNCT
fnp-4366	338	18	fth1	fth1	PROPN
fnp-4366	338	19	c.341	c.341	PROPN
fnp-4366	338	20	-	-	PUNCT
fnp-4366	338	21	342del	342del	NUM
fnp-4366	338	22	)	)	PUNCT
fnp-4366	338	23	.	.	PUNCT
fnp-4366	339	1	wild	wild	ADJ
fnp-4366	339	2	-	-	PUNCT
fnp-4366	339	3	type	type	NOUN
fnp-4366	339	4	sequence	sequence	NOUN
fnp-4366	339	5	in	in	ADP
fnp-4366	339	6	ftl	ftl	NOUN
fnp-4366	339	7	.	.	PUNCT
fnp-4366	340	1	discussion	discussion	NOUN
fnp-4366	340	2	:	:	PUNCT
fnp-4366	340	3	the	the	DET
fnp-4366	340	4	present	present	ADJ
fnp-4366	340	5	study	study	NOUN
fnp-4366	340	6	describes	describe	VERB
fnp-4366	340	7	for	for	ADP
fnp-4366	340	8	the	the	DET
fnp-4366	340	9	first	first	ADJ
fnp-4366	340	10	time	time	NOUN
fnp-4366	340	11	a	a	DET
fnp-4366	340	12	patient	patient	NOUN
fnp-4366	340	13	with	with	ADP
fnp-4366	340	14	nf	nf	NOUN
fnp-4366	340	15	caused	cause	VERB
fnp-4366	340	16	by	by	ADP
fnp-4366	340	17	a	a	DET
fnp-4366	340	18	previously	previously	ADV
fnp-4366	340	19	undescribed	undescribe	VERB
fnp-4366	340	20	mutation	mutation	NOUN
fnp-4366	340	21	in	in	ADP
fnp-4366	340	22	the	the	DET
fnp-4366	340	23	fth1	fth1	PROPN
fnp-4366	340	24	gene	gene	NOUN
fnp-4366	340	25	with	with	ADP
fnp-4366	340	26	presentation	presentation	NOUN
fnp-4366	340	27	of	of	ADP
fnp-4366	340	28	numerous	numerous	ADJ
fnp-4366	340	29	ib	ib	NOUN
fnp-4366	340	30	in	in	ADP
fnp-4366	340	31	the	the	DET
fnp-4366	340	32	brain	brain	NOUN
fnp-4366	340	33	and	and	CCONJ
fnp-4366	340	34	sporadically	sporadically	ADV
fnp-4366	340	35	in	in	ADP
fnp-4366	340	36	extracerebral	extracerebral	ADJ
fnp-4366	340	37	tissue	tissue	NOUN
fnp-4366	340	38	.	.	PUNCT
fnp-4366	341	1	these	these	DET
fnp-4366	341	2	results	result	NOUN
fnp-4366	341	3	suggest	suggest	VERB
fnp-4366	341	4	that	that	SCONJ
fnp-4366	341	5	the	the	DET
fnp-4366	341	6	function	function	NOUN
fnp-4366	341	7	of	of	ADP
fnp-4366	341	8	the	the	DET
fnp-4366	341	9	ferritin	ferritin	ADJ
fnp-4366	341	10	complex	complex	NOUN
fnp-4366	341	11	can	can	AUX
fnp-4366	341	12	be	be	AUX
fnp-4366	341	13	disturbed	disturb	VERB
fnp-4366	341	14	not	not	PART
fnp-4366	341	15	only	only	ADV
fnp-4366	341	16	by	by	ADP
fnp-4366	341	17	an	an	DET
fnp-4366	341	18	ftlbut	ftlbut	NOUN
fnp-4366	341	19	also	also	ADV
fnp-4366	341	20	by	by	ADP
fnp-4366	341	21	an	an	DET
fnp-4366	341	22	fth1	fth1	NOUN
fnp-4366	341	23	-	-	PUNCT
fnp-4366	341	24	mutation	mutation	NOUN
fnp-4366	341	25	,	,	PUNCT
fnp-4366	341	26	leading	lead	VERB
fnp-4366	341	27	to	to	ADP
fnp-4366	341	28	pathological	pathological	ADJ
fnp-4366	341	29	deposition	deposition	NOUN
fnp-4366	341	30	of	of	ADP
fnp-4366	341	31	ferritin	ferritin	ADJ
fnp-4366	341	32	complexes	complex	NOUN
fnp-4366	341	33	.	.	PUNCT
fnp-4366	342	1	with	with	ADP
fnp-4366	342	2	extended	extended	ADJ
fnp-4366	342	3	analyses	analysis	NOUN
fnp-4366	342	4	,	,	PUNCT
fnp-4366	342	5	it	it	PRON
fnp-4366	342	6	could	could	AUX
fnp-4366	342	7	be	be	AUX
fnp-4366	342	8	shown	show	VERB
fnp-4366	342	9	that	that	SCONJ
fnp-4366	342	10	the	the	DET
fnp-4366	342	11	ib	ib	NOUN
fnp-4366	342	12	correspond	correspond	VERB
fnp-4366	342	13	to	to	ADP
fnp-4366	342	14	enlarged	enlarge	VERB
fnp-4366	342	15	cell	cell	NOUN
fnp-4366	342	16	nuclei	nucleus	NOUN
fnp-4366	342	17	with	with	ADP
fnp-4366	342	18	intranuclear	intranuclear	NOUN
fnp-4366	342	19	ferritin	ferritin	ADJ
fnp-4366	342	20	accumulations	accumulation	NOUN
fnp-4366	342	21	.	.	PUNCT
fnp-4366	343	1	furthermore	furthermore	ADV
fnp-4366	343	2	,	,	PUNCT
fnp-4366	343	3	a	a	DET
fnp-4366	343	4	high	high	ADJ
fnp-4366	343	5	variability	variability	NOUN
fnp-4366	343	6	in	in	ADP
fnp-4366	343	7	distribution	distribution	NOUN
fnp-4366	343	8	of	of	ADP
fnp-4366	343	9	the	the	DET
fnp-4366	343	10	ib	ib	NOUN
fnp-4366	343	11	in	in	ADP
fnp-4366	343	12	different	different	ADJ
fnp-4366	343	13	brain	brain	NOUN
fnp-4366	343	14	regions	region	NOUN
fnp-4366	343	15	was	be	AUX
fnp-4366	343	16	found	find	VERB
fnp-4366	343	17	.	.	PUNCT
fnp-4366	344	1	summary	summary	NOUN
fnp-4366	344	2	:	:	PUNCT
fnp-4366	344	3	mutation	mutation	NOUN
fnp-4366	344	4	in	in	ADP
fnp-4366	344	5	fth1	fth1	PROPN
fnp-4366	344	6	(	(	PUNCT
fnp-4366	344	7	c.341	c.341	NOUN
fnp-4366	344	8	-	-	PUNCT
fnp-4366	344	9	342del	342del	NUM
fnp-4366	344	10	)	)	PUNCT
fnp-4366	344	11	is	be	AUX
fnp-4366	344	12	associated	associate	VERB
fnp-4366	344	13	with	with	ADP
fnp-4366	344	14	a	a	DET
fnp-4366	344	15	rare	rare	ADJ
fnp-4366	344	16	neurodegenerative	neurodegenerative	ADJ
fnp-4366	344	17	disease	disease	NOUN
fnp-4366	344	18	with	with	ADP
fnp-4366	344	19	increased	increase	VERB
fnp-4366	344	20	intranuclear	intranuclear	NOUN
fnp-4366	344	21	iron	iron	NOUN
fnp-4366	344	22	deposition	deposition	NOUN
fnp-4366	344	23	mainly	mainly	ADV
fnp-4366	344	24	in	in	ADP
fnp-4366	344	25	the	the	DET
fnp-4366	344	26	bg	bg	PROPN
fnp-4366	344	27	and	and	CCONJ
fnp-4366	344	28	dn	dn	PROPN
fnp-4366	344	29	,	,	PUNCT
fnp-4366	344	30	possibly	possibly	ADV
fnp-4366	344	31	showing	show	VERB
fnp-4366	344	32	a	a	DET
fnp-4366	344	33	similar	similar	ADJ
fnp-4366	344	34	pathomechanism	pathomechanism	NOUN
fnp-4366	344	35	to	to	ADP
fnp-4366	344	36	the	the	DET
fnp-4366	344	37	known	know	VERB
fnp-4366	344	38	ftl	ftl	NOUN
fnp-4366	344	39	-	-	PUNCT
fnp-4366	344	40	mutation	mutation	NOUN
fnp-4366	344	41	.	.	PUNCT
fnp-4366	345	1	if	if	SCONJ
fnp-4366	345	2	nf	nf	NOUN
fnp-4366	345	3	is	be	AUX
fnp-4366	345	4	clinically	clinically	ADV
fnp-4366	345	5	suspected	suspect	VERB
fnp-4366	345	6	,	,	PUNCT
fnp-4366	345	7	mutations	mutation	NOUN
fnp-4366	345	8	should	should	AUX
fnp-4366	345	9	therefore	therefore	ADV
fnp-4366	345	10	be	be	AUX
fnp-4366	345	11	investigated	investigate	VERB
fnp-4366	345	12	not	not	PART
fnp-4366	345	13	only	only	ADV
fnp-4366	345	14	in	in	ADP
fnp-4366	345	15	the	the	DET
fnp-4366	345	16	ftl	ftl	NOUN
fnp-4366	345	17	-	-	PUNCT
fnp-4366	345	18	gene	gene	NOUN
fnp-4366	345	19	but	but	CCONJ
fnp-4366	345	20	also	also	ADV
fnp-4366	345	21	in	in	ADP
fnp-4366	345	22	the	the	DET
fnp-4366	345	23	fth1	fth1	NOUN
fnp-4366	345	24	-	-	PUNCT
fnp-4366	345	25	gene	gene	NOUN
fnp-4366	345	26	.	.	PUNCT
fnp-4366	345	27	  	  	SPACE
fnp-4366	346	1	3.03	3.03	NUM
fnp-4366	346	2	free	free	ADJ
fnp-4366	346	3	neuropathol	neuropathol	NOUN
fnp-4366	346	4	3:20:37	3:20:37	NUM
fnp-4366	346	5	the	the	DET
fnp-4366	346	6	contribution	contribution	NOUN
fnp-4366	346	7	of	of	ADP
fnp-4366	346	8	late	late	PROPN
fnp-4366	346	9	-	-	PUNCT
fnp-4366	346	10	nc	nc	PROPN
fnp-4366	346	11	to	to	PART
fnp-4366	346	12	neuron	neuron	VERB
fnp-4366	346	13	loss	loss	NOUN
fnp-4366	346	14	,	,	PUNCT
fnp-4366	346	15	granulovacuolar	granulovacuolar	ADJ
fnp-4366	346	16	degeneration	degeneration	NOUN
fnp-4366	346	17	and	and	CCONJ
fnp-4366	346	18	dementia	dementia	NOUN
fnp-4366	346	19	in	in	ADP
fnp-4366	346	20	alzheimer	alzheimer	PROPN
fnp-4366	346	21	’s	’s	PART
fnp-4366	346	22	disease	disease	NOUN
fnp-4366	346	23	dietmar	dietmar	PROPN
fnp-4366	346	24	thal1,2,3	thal1,2,3	PROPN
fnp-4366	346	25	,	,	PUNCT
fnp-4366	346	26	klara	klara	PROPN
fnp-4366	346	27	gawor1,3	gawor1,3	PROPN
fnp-4366	346	28	,	,	PUNCT
fnp-4366	346	29	evelien	evelien	ADP
fnp-4366	346	30	van	van	PROPN
fnp-4366	346	31	schoor1,3,4	schoor1,3,4	PROPN
fnp-4366	346	32	,	,	PUNCT
fnp-4366	346	33	sebastiaan	sebastiaan	PROPN
fnp-4366	346	34	moonen1,3,4	moonen1,3,4	PROPN
fnp-4366	346	35	,	,	PUNCT
fnp-4366	346	36	jolien	jolien	PROPN
fnp-4366	346	37	schaeverbeke1,3,4	schaeverbeke1,3,4	NOUN
fnp-4366	346	38	,	,	PUNCT
fnp-4366	346	39	rik	rik	PROPN
fnp-4366	346	40	vandenberghe3,4,5	vandenberghe3,4,5	NOUN
fnp-4366	346	41	,	,	PUNCT
fnp-4366	346	42	mathieu	mathieu	PROPN
fnp-4366	346	43	vandenbulcke3,4,6	vandenbulcke3,4,6	PROPN
fnp-4366	346	44	,	,	PUNCT
fnp-4366	346	45	christine	christine	PROPN
fnp-4366	346	46	a.	a.	PROPN
fnp-4366	346	47	f.	f.	PROPN
fnp-4366	346	48	von	von	PROPN
fnp-4366	346	49	arnim7,8	arnim7,8	PROPN
fnp-4366	346	50	,	,	PUNCT
fnp-4366	346	51	marta	marta	PROPN
fnp-4366	346	52	koper1,3,4	koper1,3,4	PROPN
fnp-4366	346	53	,	,	PUNCT
fnp-4366	346	54	sandra	sandra	PROPN
fnp-4366	346	55	tomé1,3	tomé1,3	PROPN
fnp-4366	346	56	1	1	NUM
fnp-4366	346	57	ku	ku	PROPN
fnp-4366	346	58	-	-	PUNCT
fnp-4366	346	59	leuven	leuven	NOUN
fnp-4366	346	60	,	,	PUNCT
fnp-4366	346	61	department	department	NOUN
fnp-4366	346	62	of	of	ADP
fnp-4366	346	63	imaging	imaging	NOUN
fnp-4366	346	64	and	and	CCONJ
fnp-4366	346	65	pathology	pathology	NOUN
fnp-4366	346	66	,	,	PUNCT
fnp-4366	346	67	laboratory	laboratory	NOUN
fnp-4366	346	68	for	for	ADP
fnp-4366	346	69	neuropathology	neuropathology	NOUN
fnp-4366	346	70	,	,	PUNCT
fnp-4366	346	71	leuven	leuven	PROPN
fnp-4366	346	72	,	,	PUNCT
fnp-4366	346	73	belgium	belgium	PROPN
fnp-4366	346	74	2	2	NUM
fnp-4366	346	75	uz	uz	PROPN
fnp-4366	346	76	leuven	leuven	PROPN
fnp-4366	346	77	,	,	PUNCT
fnp-4366	346	78	department	department	NOUN
fnp-4366	346	79	of	of	ADP
fnp-4366	346	80	pathology	pathology	PROPN
fnp-4366	346	81	,	,	PUNCT
fnp-4366	346	82	leuven	leuven	PROPN
fnp-4366	346	83	,	,	PUNCT
fnp-4366	346	84	belgium	belgium	PROPN
fnp-4366	346	85	3	3	NUM
fnp-4366	346	86	leuven	leuven	PROPN
fnp-4366	346	87	brain	brain	PROPN
fnp-4366	346	88	institute	institute	PROPN
fnp-4366	346	89	,	,	PUNCT
fnp-4366	346	90	leuven	leuven	PROPN
fnp-4366	346	91	,	,	PUNCT
fnp-4366	346	92	belgium	belgium	PROPN
fnp-4366	346	93	4	4	NUM
fnp-4366	346	94	ku	ku	PROPN
fnp-4366	346	95	leuven	leuven	PROPN
fnp-4366	346	96	,	,	PUNCT
fnp-4366	346	97	department	department	NOUN
fnp-4366	346	98	of	of	ADP
fnp-4366	346	99	neuroscience	neuroscience	NOUN
fnp-4366	346	100	,	,	PUNCT
fnp-4366	346	101	leuven	leuven	PROPN
fnp-4366	346	102	,	,	PUNCT
fnp-4366	346	103	belgium	belgium	PROPN
fnp-4366	346	104	5	5	NUM
fnp-4366	346	105	uz	uz	PROPN
fnp-4366	346	106	leuven	leuven	PROPN
fnp-4366	346	107	,	,	PUNCT
fnp-4366	346	108	department	department	NOUN
fnp-4366	346	109	of	of	ADP
fnp-4366	346	110	neurology	neurology	NOUN
fnp-4366	346	111	,	,	PUNCT
fnp-4366	346	112	leuven	leuven	PROPN
fnp-4366	346	113	,	,	PUNCT
fnp-4366	346	114	belgium	belgium	PROPN
fnp-4366	346	115	6	6	NUM
fnp-4366	346	116	uz	uz	PROPN
fnp-4366	346	117	leuven	leuven	PROPN
fnp-4366	346	118	,	,	PUNCT
fnp-4366	346	119	department	department	NOUN
fnp-4366	346	120	of	of	ADP
fnp-4366	346	121	psychiatry	psychiatry	NOUN
fnp-4366	346	122	,	,	PUNCT
fnp-4366	346	123	leuven	leuven	PROPN
fnp-4366	346	124	,	,	PUNCT
fnp-4366	346	125	belgium	belgium	NOUN
fnp-4366	346	126	7	7	NUM
fnp-4366	346	127	göttingen	göttingen	PROPN
fnp-4366	346	128	university	university	NOUN
fnp-4366	346	129	,	,	PUNCT
fnp-4366	346	130	department	department	NOUN
fnp-4366	346	131	of	of	ADP
fnp-4366	346	132	geriatrics	geriatric	NOUN
fnp-4366	346	133	,	,	PUNCT
fnp-4366	346	134	göttingen	göttingen	NOUN
fnp-4366	346	135	,	,	PUNCT
fnp-4366	346	136	deutschland	deutschland	NOUN
fnp-4366	346	137	8	8	NUM
fnp-4366	346	138	ulm	ulm	NOUN
fnp-4366	346	139	university	university	PROPN
fnp-4366	346	140	,	,	PUNCT
fnp-4366	346	141	neurology	neurology	NOUN
fnp-4366	346	142	,	,	PUNCT
fnp-4366	346	143	ulm	ulm	PROPN
fnp-4366	346	144	,	,	PUNCT
fnp-4366	346	145	deutschland	deutschland	NOUN
fnp-4366	346	146	background	background	NOUN
fnp-4366	346	147	:	:	PUNCT
fnp-4366	346	148	tdp-43	tdp-43	PROPN
fnp-4366	346	149	pathology	pathology	PROPN
fnp-4366	346	150	in	in	ADP
fnp-4366	346	151	alzheimer	alzheimer	PROPN
fnp-4366	346	152	’s	’s	PART
fnp-4366	346	153	disease	disease	NOUN
fnp-4366	346	154	(	(	PUNCT
fnp-4366	346	155	ad	ad	NOUN
fnp-4366	346	156	)	)	PUNCT
fnp-4366	346	157	is	be	AUX
fnp-4366	346	158	currently	currently	ADV
fnp-4366	346	159	considered	consider	VERB
fnp-4366	346	160	as	as	ADP
fnp-4366	346	161	a	a	DET
fnp-4366	346	162	co	co	NOUN
fnp-4366	346	163	-	-	NOUN
fnp-4366	346	164	pathology	pathology	NOUN
fnp-4366	346	165	belonging	belong	VERB
fnp-4366	346	166	to	to	ADP
fnp-4366	346	167	the	the	DET
fnp-4366	346	168	spectrum	spectrum	NOUN
fnp-4366	346	169	of	of	ADP
fnp-4366	346	170	limbic	limbic	NOUN
fnp-4366	346	171	-	-	PUNCT
fnp-4366	346	172	predominant	predominant	ADJ
fnp-4366	346	173	,	,	PUNCT
fnp-4366	346	174	age	age	NOUN
fnp-4366	346	175	-	-	PUNCT
fnp-4366	346	176	associated	associate	VERB
fnp-4366	346	177	tdp-43	tdp-43	NOUN
fnp-4366	346	178	encephalopathy	encephalopathy	ADV
fnp-4366	346	179	(	(	PUNCT
fnp-4366	346	180	late	late	ADJ
fnp-4366	346	181	)	)	PUNCT
fnp-4366	346	182	.	.	PUNCT
fnp-4366	347	1	ad	ad	NOUN
fnp-4366	347	2	cases	case	NOUN
fnp-4366	347	3	with	with	ADP
fnp-4366	347	4	tdp-43	tdp-43	PROPN
fnp-4366	347	5	pathology	pathology	NOUN
fnp-4366	347	6	have	have	VERB
fnp-4366	347	7	greater	great	ADJ
fnp-4366	347	8	medial	medial	ADJ
fnp-4366	347	9	temporal	temporal	ADJ
fnp-4366	347	10	lobe	lobe	ADJ
fnp-4366	347	11	atrophy	atrophy	NOUN
fnp-4366	347	12	and	and	CCONJ
fnp-4366	347	13	cognitive	cognitive	ADJ
fnp-4366	347	14	decline	decline	NOUN
fnp-4366	347	15	compared	compare	VERB
fnp-4366	347	16	to	to	ADP
fnp-4366	347	17	ad	ad	NOUN
fnp-4366	347	18	cases	case	NOUN
fnp-4366	347	19	without	without	ADP
fnp-4366	347	20	tdp-43	tdp-43	NOUN
fnp-4366	347	21	.	.	PUNCT
fnp-4366	348	1	recently	recently	ADV
fnp-4366	348	2	,	,	PUNCT
fnp-4366	348	3	we	we	PRON
fnp-4366	348	4	showed	show	VERB
fnp-4366	348	5	that	that	SCONJ
fnp-4366	348	6	the	the	DET
fnp-4366	348	7	accumulation	accumulation	NOUN
fnp-4366	348	8	of	of	ADP
fnp-4366	348	9	the	the	DET
fnp-4366	348	10	necrosome	necrosome	NOUN
fnp-4366	348	11	(	(	PUNCT
fnp-4366	348	12	executer	executer	NOUN
fnp-4366	348	13	complex	complex	NOUN
fnp-4366	348	14	of	of	ADP
fnp-4366	348	15	necroptosis	necroptosis	NOUN
fnp-4366	348	16	which	which	PRON
fnp-4366	348	17	is	be	AUX
fnp-4366	348	18	a	a	DET
fnp-4366	348	19	programmed	program	VERB
fnp-4366	348	20	from	from	ADP
fnp-4366	348	21	of	of	ADP
fnp-4366	348	22	necrosis	necrosis	NOUN
fnp-4366	348	23	)	)	PUNCT
fnp-4366	348	24	in	in	ADP
fnp-4366	348	25	granulovacuolar	granulovacuolar	ADJ
fnp-4366	348	26	degeneration	degeneration	NOUN
fnp-4366	348	27	(	(	PUNCT
fnp-4366	348	28	gvd	gvd	PROPN
fnp-4366	348	29	)	)	PUNCT
fnp-4366	348	30	in	in	ADP
fnp-4366	348	31	ad	ad	NOUN
fnp-4366	348	32	is	be	AUX
fnp-4366	348	33	associated	associate	VERB
fnp-4366	348	34	with	with	ADP
fnp-4366	348	35	neuron	neuron	NOUN
fnp-4366	348	36	loss	loss	NOUN
fnp-4366	348	37	.	.	PUNCT
fnp-4366	349	1	aims	aim	NOUN
fnp-4366	349	2	:	:	PUNCT
fnp-4366	349	3	here	here	ADV
fnp-4366	349	4	,	,	PUNCT
fnp-4366	349	5	we	we	PRON
fnp-4366	349	6	aim	aim	VERB
fnp-4366	349	7	to	to	PART
fnp-4366	349	8	clarify	clarify	VERB
fnp-4366	349	9	whether	whether	SCONJ
fnp-4366	349	10	necroptosis	necroptosis	NOUN
fnp-4366	349	11	in	in	ADP
fnp-4366	349	12	ad	ad	NOUN
fnp-4366	349	13	is	be	AUX
fnp-4366	349	14	related	relate	VERB
fnp-4366	349	15	to	to	ADP
fnp-4366	349	16	tdp-43	tdp-43	PROPN
fnp-4366	349	17	pathology	pathology	PROPN
fnp-4366	349	18	,	,	PUNCT
fnp-4366	349	19	i.e.	i.e.	X
fnp-4366	349	20	,	,	PUNCT
fnp-4366	349	21	late	late	ADJ
fnp-4366	349	22	neuropathological	neuropathological	ADJ
fnp-4366	349	23	changes	change	NOUN
fnp-4366	349	24	(	(	PUNCT
fnp-4366	349	25	late	late	PROPN
fnp-4366	349	26	-	-	PUNCT
fnp-4366	349	27	nc	nc	NOUN
fnp-4366	349	28	)	)	PUNCT
fnp-4366	349	29	and	and	CCONJ
fnp-4366	349	30	indicates	indicate	VERB
fnp-4366	349	31	a	a	DET
fnp-4366	349	32	contribution	contribution	NOUN
fnp-4366	349	33	of	of	ADP
fnp-4366	349	34	late	late	ADJ
fnp-4366	349	35	-	-	PUNCT
fnp-4366	349	36	nc	nc	PROPN
fnp-4366	349	37	to	to	ADP
fnp-4366	349	38	the	the	DET
fnp-4366	349	39	degeneration/	degeneration/	NUM
fnp-4366	349	40	death	death	NOUN
fnp-4366	349	41	of	of	ADP
fnp-4366	349	42	neurons	neuron	NOUN
fnp-4366	349	43	in	in	ADP
fnp-4366	349	44	ad	ad	NOUN
fnp-4366	349	45	.	.	PUNCT
fnp-4366	350	1	by	by	ADP
fnp-4366	350	2	doing	do	VERB
fnp-4366	350	3	so	so	ADV
fnp-4366	350	4	,	,	PUNCT
fnp-4366	350	5	we	we	PRON
fnp-4366	350	6	will	will	AUX
fnp-4366	350	7	determine	determine	VERB
fnp-4366	350	8	the	the	DET
fnp-4366	350	9	impact	impact	NOUN
fnp-4366	350	10	of	of	ADP
fnp-4366	350	11	late	late	ADJ
fnp-4366	350	12	-	-	PUNCT
fnp-4366	350	13	nc	nc	PROPN
fnp-4366	350	14	on	on	ADP
fnp-4366	350	15	ad	ad	NOUN
fnp-4366	350	16	-	-	PUNCT
fnp-4366	350	17	nc	nc	PROPN
fnp-4366	350	18	,	,	PUNCT
fnp-4366	350	19	neuron	neuron	NOUN
fnp-4366	350	20	loss	loss	NOUN
fnp-4366	350	21	,	,	PUNCT
fnp-4366	350	22	especially	especially	ADV
fnp-4366	350	23	necroptosis	necroptosis	NOUN
fnp-4366	350	24	,	,	PUNCT
fnp-4366	350	25	and	and	CCONJ
fnp-4366	350	26	cognitive	cognitive	ADJ
fnp-4366	350	27	decline	decline	NOUN
fnp-4366	350	28	.	.	PUNCT
fnp-4366	351	1	research	research	NOUN
fnp-4366	351	2	question	question	NOUN
fnp-4366	351	3	:	:	PUNCT
fnp-4366	351	4	does	do	AUX
fnp-4366	351	5	tdp-43	tdp-43	VERB
fnp-4366	351	6	pathology	pathology	PROPN
fnp-4366	351	7	in	in	ADP
fnp-4366	351	8	late	late	ADJ
fnp-4366	351	9	contribute	contribute	NOUN
fnp-4366	351	10	to	to	ADP
fnp-4366	351	11	neurodegeneration	neurodegeneration	NOUN
fnp-4366	351	12	via	via	ADP
fnp-4366	351	13	necrosome	necrosome	ADJ
fnp-4366	351	14	accumulation	accumulation	NOUN
fnp-4366	351	15	and	and	CCONJ
fnp-4366	351	16	necroptosis	necroptosis	NOUN
fnp-4366	351	17	in	in	ADP
fnp-4366	351	18	ad	ad	NOUN
fnp-4366	351	19	and	and	CCONJ
fnp-4366	351	20	,	,	PUNCT
fnp-4366	351	21	if	if	SCONJ
fnp-4366	351	22	so	so	ADV
fnp-4366	351	23	,	,	PUNCT
fnp-4366	351	24	is	be	AUX
fnp-4366	351	25	this	this	PRON
fnp-4366	351	26	related	related	ADJ
fnp-4366	351	27	to	to	ADP
fnp-4366	351	28	tau	tau	PROPN
fnp-4366	351	29	pathology	pathology	PROPN
fnp-4366	351	30	.	.	PUNCT
fnp-4366	352	1	methods	method	NOUN
fnp-4366	352	2	:	:	PUNCT
fnp-4366	352	3	we	we	PRON
fnp-4366	352	4	used	use	VERB
fnp-4366	352	5	234	234	NUM
fnp-4366	352	6	human	human	ADJ
fnp-4366	352	7	post	post	ADJ
fnp-4366	352	8	-	-	ADJ
fnp-4366	352	9	mortem	mortem	ADJ
fnp-4366	352	10	brains	brain	NOUN
fnp-4366	352	11	from	from	ADP
fnp-4366	352	12	89	89	NUM
fnp-4366	352	13	non	non	ADJ
fnp-4366	352	14	-	-	ADJ
fnp-4366	352	15	ad	ad	ADJ
fnp-4366	352	16	controls	control	NOUN
fnp-4366	352	17	,	,	PUNCT
fnp-4366	352	18	82	82	NUM
fnp-4366	352	19	p	p	ADV
fnp-4366	352	20	-	-	PUNCT
fnp-4366	352	21	pread	pread	NOUN
fnp-4366	352	22	and	and	CCONJ
fnp-4366	352	23	63	63	NUM
fnp-4366	352	24	ad	ad	NOUN
fnp-4366	352	25	cases	case	NOUN
fnp-4366	352	26	.	.	PUNCT
fnp-4366	353	1	we	we	PRON
fnp-4366	353	2	determined	determine	VERB
fnp-4366	353	3	amyloid	amyloid	NOUN
fnp-4366	353	4	-	-	PUNCT
fnp-4366	353	5	β	β	X
fnp-4366	353	6	(	(	PUNCT
fnp-4366	353	7	aβ	aβ	NOUN
fnp-4366	353	8	)	)	PUNCT
fnp-4366	353	9	(	(	PUNCT
fnp-4366	353	10	mtl	mtl	PROPN
fnp-4366	353	11	=	=	SYM
fnp-4366	353	12	medial	medial	ADJ
fnp-4366	353	13	temporal	temporal	ADJ
fnp-4366	353	14	lobe	lobe	NOUN
fnp-4366	353	15	-	-	PUNCT
fnp-4366	353	16	based	base	VERB
fnp-4366	353	17	)	)	PUNCT
fnp-4366	353	18	phases	phase	NOUN
fnp-4366	353	19	,	,	PUNCT
fnp-4366	353	20	braak	braak	NOUN
fnp-4366	353	21	neurofibrillary	neurofibrillary	ADJ
fnp-4366	353	22	tangle	tangle	NOUN
fnp-4366	353	23	(	(	PUNCT
fnp-4366	353	24	nft	nft	PROPN
fnp-4366	353	25	)	)	PUNCT
fnp-4366	353	26	stages	stage	NOUN
fnp-4366	353	27	,	,	PUNCT
fnp-4366	353	28	late	late	ADJ
fnp-4366	353	29	-	-	PUNCT
fnp-4366	353	30	nc	nc	NOUN
fnp-4366	353	31	stages	stage	NOUN
fnp-4366	353	32	and	and	CCONJ
fnp-4366	353	33	gvd	gvd	VERB
fnp-4366	353	34	stages	stage	NOUN
fnp-4366	353	35	,	,	PUNCT
fnp-4366	353	36	which	which	PRON
fnp-4366	353	37	described	describe	VERB
fnp-4366	353	38	the	the	DET
fnp-4366	353	39	anatomical	anatomical	ADJ
fnp-4366	353	40	spread	spread	NOUN
fnp-4366	353	41	of	of	ADP
fnp-4366	353	42	gvd	gvd	NOUN
fnp-4366	353	43	bodies	body	NOUN
fnp-4366	353	44	,	,	PUNCT
fnp-4366	353	45	and	and	CCONJ
fnp-4366	353	46	the	the	DET
fnp-4366	353	47	frequency	frequency	NOUN
fnp-4366	353	48	of	of	ADP
fnp-4366	353	49	gvd	gvd	NOUN
fnp-4366	353	50	-	-	PUNCT
fnp-4366	353	51	affected	affect	VERB
fnp-4366	353	52	neurons	neuron	NOUN
fnp-4366	353	53	in	in	ADP
fnp-4366	353	54	a	a	DET
fnp-4366	353	55	given	give	VERB
fnp-4366	353	56	region	region	NOUN
fnp-4366	353	57	.	.	PUNCT
fnp-4366	354	1	from	from	ADP
fnp-4366	354	2	these	these	PRON
fnp-4366	354	3	,	,	PUNCT
fnp-4366	354	4	66	66	NUM
fnp-4366	354	5	cases	case	NOUN
fnp-4366	354	6	were	be	AUX
fnp-4366	354	7	assessed	assess	VERB
fnp-4366	354	8	for	for	ADP
fnp-4366	354	9	neuronal	neuronal	ADJ
fnp-4366	354	10	density	density	NOUN
fnp-4366	354	11	in	in	ADP
fnp-4366	354	12	the	the	DET
fnp-4366	354	13	ca1	ca1	NOUN
fnp-4366	354	14	subfield	subfield	NOUN
fnp-4366	354	15	of	of	ADP
fnp-4366	354	16	the	the	DET
fnp-4366	354	17	hippocampal	hippocampal	ADJ
fnp-4366	354	18	formation	formation	NOUN
fnp-4366	354	19	and	and	CCONJ
fnp-4366	354	20	186	186	NUM
fnp-4366	354	21	were	be	AUX
fnp-4366	354	22	retrospectively	retrospectively	ADV
fnp-4366	354	23	assessed	assess	VERB
fnp-4366	354	24	for	for	ADP
fnp-4366	354	25	clinical	clinical	ADJ
fnp-4366	354	26	dementia	dementia	NOUN
fnp-4366	354	27	rating	rating	NOUN
fnp-4366	354	28	(	(	PUNCT
fnp-4366	354	29	cdr	cdr	NOUN
fnp-4366	354	30	)	)	PUNCT
fnp-4366	354	31	scores	score	NOUN
fnp-4366	354	32	.	.	PUNCT
fnp-4366	355	1	in	in	ADP
fnp-4366	355	2	a	a	DET
fnp-4366	355	3	subset	subset	NOUN
fnp-4366	355	4	of	of	ADP
fnp-4366	355	5	27	27	NUM
fnp-4366	355	6	cases	case	NOUN
fnp-4366	355	7	covering	cover	VERB
fnp-4366	355	8	9	9	NUM
fnp-4366	355	9	non	non	ADJ
fnp-4366	355	10	-	-	ADJ
fnp-4366	355	11	ad	ad	ADJ
fnp-4366	355	12	controls	control	NOUN
fnp-4366	355	13	(	(	PUNCT
fnp-4366	355	14	without	without	ADP
fnp-4366	355	15	tdp-43	tdp-43	PROPN
fnp-4366	355	16	pathology	pathology	NOUN
fnp-4366	355	17	)	)	PUNCT
fnp-4366	355	18	,	,	PUNCT
fnp-4366	355	19	8	8	NUM
fnp-4366	355	20	symptomatic	symptomatic	ADJ
fnp-4366	355	21	ad	ad	NOUN
fnp-4366	355	22	cases	case	NOUN
fnp-4366	355	23	without	without	ADP
fnp-4366	355	24	tdp-43	tdp-43	PROPN
fnp-4366	355	25	pathology	pathology	PROPN
fnp-4366	355	26	(	(	PUNCT
fnp-4366	355	27	adtdp-	adtdp-	X
fnp-4366	355	28	)	)	PUNCT
fnp-4366	355	29	and	and	CCONJ
fnp-4366	355	30	10	10	NUM
fnp-4366	355	31	symptomatic	symptomatic	ADJ
fnp-4366	355	32	ad	ad	NOUN
fnp-4366	355	33	cases	case	NOUN
fnp-4366	355	34	with	with	ADP
fnp-4366	355	35	tdp-43	tdp-43	NOUN
fnp-4366	355	36	proteinopathy	proteinopathy	ADJ
fnp-4366	355	37	(	(	PUNCT
fnp-4366	355	38	i.e.	i.e.	X
fnp-4366	355	39	:	:	PUNCT
fnp-4366	355	40	late	late	ADJ
fnp-4366	355	41	-	-	PUNCT
fnp-4366	355	42	nc	nc	PROPN
fnp-4366	355	43	;	;	PUNCT
fnp-4366	355	44	adtdp+	adtdp+	NOUN
fnp-4366	355	45	)	)	PUNCT
fnp-4366	355	46	,	,	PUNCT
fnp-4366	355	47	we	we	PRON
fnp-4366	355	48	quantified	quantify	VERB
fnp-4366	355	49	neuronal	neuronal	ADJ
fnp-4366	355	50	density	density	NOUN
fnp-4366	355	51	,	,	PUNCT
fnp-4366	355	52	severity	severity	NOUN
fnp-4366	355	53	of	of	ADP
fnp-4366	355	54	ptdp-43	ptdp-43	PROPN
fnp-4366	355	55	,	,	PUNCT
fnp-4366	355	56	pmlkl	pmlkl	NOUN
fnp-4366	355	57	(	(	PUNCT
fnp-4366	355	58	a	a	DET
fnp-4366	355	59	component	component	NOUN
fnp-4366	355	60	of	of	ADP
fnp-4366	355	61	the	the	DET
fnp-4366	355	62	activated	activate	VERB
fnp-4366	355	63	necrosome	necrosome	NOUN
fnp-4366	355	64	)	)	PUNCT
fnp-4366	355	65	and	and	CCONJ
fnp-4366	355	66	ptau	ptau	ADV
fnp-4366	355	67	pathology	pathology	NOUN
fnp-4366	355	68	.	.	PUNCT
fnp-4366	356	1	results	result	NOUN
fnp-4366	356	2	:	:	PUNCT
fnp-4366	356	3	we	we	PRON
fnp-4366	356	4	found	find	VERB
fnp-4366	356	5	that	that	SCONJ
fnp-4366	356	6	late	late	ADJ
fnp-4366	356	7	-	-	PUNCT
fnp-4366	356	8	nc	nc	PROPN
fnp-4366	356	9	and	and	CCONJ
fnp-4366	356	10	braak	braak	PROPN
fnp-4366	356	11	nft	nft	PROPN
fnp-4366	356	12	stages	stage	NOUN
fnp-4366	356	13	contribute	contribute	VERB
fnp-4366	356	14	independently	independently	ADV
fnp-4366	356	15	to	to	PART
fnp-4366	356	16	gvd	gvd	VERB
fnp-4366	356	17	severity	severity	NOUN
fnp-4366	356	18	when	when	SCONJ
fnp-4366	356	19	being	be	AUX
fnp-4366	356	20	covariates	covariate	VERB
fnp-4366	356	21	the	the	DET
fnp-4366	356	22	same	same	ADJ
fnp-4366	356	23	model	model	NOUN
fnp-4366	356	24	term	term	NOUN
fnp-4366	356	25	(	(	PUNCT
fnp-4366	356	26	p	p	X
fnp-4366	356	27	<	<	X
fnp-4366	356	28	0.001	0.001	NUM
fnp-4366	356	29	)	)	PUNCT
fnp-4366	356	30	.	.	PUNCT
fnp-4366	357	1	late	late	PROPN
fnp-4366	357	2	-	-	PUNCT
fnp-4366	357	3	nc	nc	PROPN
fnp-4366	357	4	and	and	CCONJ
fnp-4366	357	5	braak	braak	PROPN
fnp-4366	357	6	nft	nft	PROPN
fnp-4366	357	7	stages	stage	NOUN
fnp-4366	357	8	were	be	AUX
fnp-4366	357	9	associated	associate	VERB
fnp-4366	357	10	with	with	ADP
fnp-4366	357	11	neuronal	neuronal	ADJ
fnp-4366	357	12	density	density	NOUN
fnp-4366	357	13	in	in	ADP
fnp-4366	357	14	the	the	DET
fnp-4366	357	15	hippocampus	hippocampus	NOUN
fnp-4366	357	16	(	(	PUNCT
fnp-4366	357	17	p	p	X
fnp-4366	357	18	=	=	NOUN
fnp-4366	357	19	0.022	0.022	NUM
fnp-4366	357	20	and	and	CCONJ
fnp-4366	357	21	p	p	NOUN
fnp-4366	357	22	=	=	NOUN
fnp-4366	357	23	0.004	0.004	NUM
fnp-4366	357	24	,	,	PUNCT
fnp-4366	357	25	respectively	respectively	ADV
fnp-4366	357	26	)	)	PUNCT
fnp-4366	357	27	.	.	PUNCT
fnp-4366	358	1	braak	braak	PROPN
fnp-4366	358	2	nft	nft	PROPN
fnp-4366	358	3	stage	stage	PROPN
fnp-4366	358	4	alone	alone	ADV
fnp-4366	358	5	showed	show	VERB
fnp-4366	358	6	also	also	ADV
fnp-4366	358	7	an	an	DET
fnp-4366	358	8	association	association	NOUN
fnp-4366	358	9	with	with	ADP
fnp-4366	358	10	neuronal	neuronal	ADJ
fnp-4366	358	11	density	density	NOUN
fnp-4366	358	12	(	(	PUNCT
fnp-4366	358	13	p	p	X
fnp-4366	358	14	<	<	X
fnp-4366	358	15	0.001	0.001	NUM
fnp-4366	358	16	)	)	PUNCT
fnp-4366	358	17	.	.	PUNCT
fnp-4366	359	1	partial	partial	ADJ
fnp-4366	359	2	correlation	correlation	NOUN
fnp-4366	359	3	analysis	analysis	NOUN
fnp-4366	359	4	corroborated	corroborate	VERB
fnp-4366	359	5	these	these	DET
fnp-4366	359	6	data	datum	NOUN
fnp-4366	359	7	and	and	CCONJ
fnp-4366	359	8	revealed	reveal	VERB
fnp-4366	359	9	that	that	SCONJ
fnp-4366	359	10	braak	braak	PROPN
fnp-4366	359	11	nft	nft	PROPN
fnp-4366	359	12	and	and	CCONJ
fnp-4366	359	13	late	late	PROPN
fnp-4366	359	14	-	-	PUNCT
fnp-4366	359	15	nc	nc	NOUN
fnp-4366	359	16	stage	stage	NOUN
fnp-4366	359	17	are	be	AUX
fnp-4366	359	18	significantly	significantly	ADV
fnp-4366	359	19	correlated	correlate	VERB
fnp-4366	359	20	with	with	ADP
fnp-4366	359	21	gvd	gvd	NOUN
fnp-4366	359	22	stage	stage	NOUN
fnp-4366	359	23	and	and	CCONJ
fnp-4366	359	24	cdr	cdr	PROPN
fnp-4366	359	25	score	score	NOUN
fnp-4366	359	26	.	.	PUNCT
fnp-4366	360	1	in	in	ADP
fnp-4366	360	2	the	the	DET
fnp-4366	360	3	27	27	NUM
fnp-4366	360	4	cases	case	NOUN
fnp-4366	360	5	used	use	VERB
fnp-4366	360	6	for	for	ADP
fnp-4366	360	7	quantitative	quantitative	ADJ
fnp-4366	360	8	assessments	assessment	NOUN
fnp-4366	360	9	,	,	PUNCT
fnp-4366	360	10	the	the	DET
fnp-4366	360	11	absence	absence	NOUN
fnp-4366	360	12	of	of	ADP
fnp-4366	360	13	ptdp-43	ptdp-43	PROPN
fnp-4366	360	14	was	be	AUX
fnp-4366	360	15	associated	associate	VERB
fnp-4366	360	16	with	with	ADP
fnp-4366	360	17	less	less	ADJ
fnp-4366	360	18	neuronal	neuronal	ADJ
fnp-4366	360	19	loss	loss	NOUN
fnp-4366	360	20	in	in	ADP
fnp-4366	360	21	adtdpcases	adtdpcase	NOUN
fnp-4366	360	22	compared	compare	VERB
fnp-4366	360	23	to	to	ADP
fnp-4366	360	24	adtdp+	adtdp+	NOUN
fnp-4366	360	25	(	(	PUNCT
fnp-4366	360	26	p	p	X
fnp-4366	360	27	=	=	NOUN
fnp-4366	360	28	0.0204	0.0204	NUM
fnp-4366	360	29	)	)	PUNCT
fnp-4366	360	30	.	.	PUNCT
fnp-4366	361	1	adtdp+	adtdp+	NOUN
fnp-4366	362	1	cases	case	NOUN
fnp-4366	362	2	exhibited	exhibit	VERB
fnp-4366	362	3	significantly	significantly	ADV
fnp-4366	362	4	more	more	ADJ
fnp-4366	362	5	pmlkl	pmlkl	NOUN
fnp-4366	362	6	-	-	PUNCT
fnp-4366	362	7	positive	positive	ADJ
fnp-4366	362	8	neurons	neuron	NOUN
fnp-4366	362	9	,	,	PUNCT
fnp-4366	362	10	when	when	SCONJ
fnp-4366	362	11	compared	compare	VERB
fnp-4366	362	12	to	to	ADP
fnp-4366	362	13	adtdpcases	adtdpcases	PROPN
fnp-4366	362	14	(	(	PUNCT
fnp-4366	362	15	p	p	X
fnp-4366	362	16	=	=	NOUN
fnp-4366	362	17	0.025	0.025	NUM
fnp-4366	362	18	)	)	PUNCT
fnp-4366	362	19	and	and	CCONJ
fnp-4366	362	20	non	non	ADJ
fnp-4366	362	21	-	-	ADJ
fnp-4366	362	22	diseased	diseased	ADJ
fnp-4366	362	23	controls	control	NOUN
fnp-4366	362	24	(	(	PUNCT
fnp-4366	362	25	p	p	X
fnp-4366	362	26	<	<	X
fnp-4366	362	27	0.0001	0.0001	NUM
fnp-4366	362	28	)	)	PUNCT
fnp-4366	362	29	.	.	PUNCT
fnp-4366	363	1	consistently	consistently	ADV
fnp-4366	363	2	,	,	PUNCT
fnp-4366	363	3	adtdp+	adtdp+	VERB
fnp-4366	363	4	cases	case	NOUN
fnp-4366	363	5	also	also	ADV
fnp-4366	363	6	showed	show	VERB
fnp-4366	363	7	enhanced	enhanced	ADJ
fnp-4366	363	8	numbers	number	NOUN
fnp-4366	363	9	of	of	ADP
fnp-4366	363	10	ptau	ptau	ADV
fnp-4366	363	11	exhibiting	exhibit	VERB
fnp-4366	363	12	neurons	neuron	NOUN
fnp-4366	363	13	compared	compare	VERB
fnp-4366	363	14	to	to	ADP
fnp-4366	363	15	adtdp(p	adtdp(p	NOUN
fnp-4366	363	16	=	=	SYM
fnp-4366	363	17	0.045	0.045	NUM
fnp-4366	363	18	)	)	PUNCT
fnp-4366	363	19	and	and	CCONJ
fnp-4366	363	20	controls	control	NOUN
fnp-4366	363	21	(	(	PUNCT
fnp-4366	363	22	p	p	X
fnp-4366	363	23	<	<	X
fnp-4366	363	24	0.0001	0.0001	NUM
fnp-4366	363	25	)	)	PUNCT
fnp-4366	363	26	.	.	PUNCT
fnp-4366	364	1	conclusions	conclusion	NOUN
fnp-4366	364	2	:	:	PUNCT
fnp-4366	364	3	thus	thus	ADV
fnp-4366	364	4	,	,	PUNCT
fnp-4366	364	5	late	late	PROPN
fnp-4366	364	6	-	-	PUNCT
fnp-4366	364	7	nc	nc	PROPN
fnp-4366	364	8	contributes	contribute	VERB
fnp-4366	364	9	independently	independently	ADV
fnp-4366	364	10	to	to	ADP
fnp-4366	364	11	neuronal	neuronal	ADJ
fnp-4366	364	12	loss	loss	NOUN
fnp-4366	364	13	and	and	CCONJ
fnp-4366	364	14	gvd	gvd	NOUN
fnp-4366	364	15	severity	severity	NOUN
fnp-4366	364	16	.	.	PUNCT
fnp-4366	365	1	further	far	ADV
fnp-4366	365	2	,	,	PUNCT
fnp-4366	365	3	these	these	DET
fnp-4366	365	4	data	datum	NOUN
fnp-4366	365	5	highlight	highlight	VERB
fnp-4366	365	6	the	the	DET
fnp-4366	365	7	impact	impact	NOUN
fnp-4366	365	8	of	of	ADP
fnp-4366	365	9	cytoplasmic	cytoplasmic	ADJ
fnp-4366	365	10	tdp-43	tdp-43	PROPN
fnp-4366	365	11	aggregation	aggregation	NOUN
fnp-4366	365	12	on	on	ADP
fnp-4366	365	13	ptau	ptau	PROPN
fnp-4366	365	14	pathology	pathology	NOUN
fnp-4366	365	15	as	as	ADV
fnp-4366	365	16	well	well	ADV
fnp-4366	365	17	as	as	ADP
fnp-4366	365	18	on	on	ADP
fnp-4366	365	19	necroptosis	necroptosis	NOUN
fnp-4366	365	20	activation	activation	NOUN
fnp-4366	365	21	in	in	ADP
fnp-4366	365	22	ad	ad	NOUN
fnp-4366	365	23	.	.	PUNCT
fnp-4366	366	1	support	support	NOUN
fnp-4366	366	2	:	:	PUNCT
fnp-4366	366	3	fwo	fwo	PROPN
fnp-4366	366	4	.	.	PUNCT
fnp-4366	366	5	  	  	SPACE
fnp-4366	366	6	3.04	3.04	NUM
fnp-4366	366	7	free	free	ADJ
fnp-4366	366	8	neuropathol	neuropathol	NOUN
fnp-4366	366	9	3:20:39	3:20:39	NUM
fnp-4366	366	10	the	the	DET
fnp-4366	366	11	role	role	NOUN
fnp-4366	366	12	of	of	ADP
fnp-4366	366	13	c3	c3	PROPN
fnp-4366	366	14	inhibition	inhibition	NOUN
fnp-4366	366	15	in	in	ADP
fnp-4366	366	16	an	an	DET
fnp-4366	366	17	ipsc	ipsc	NOUN
fnp-4366	366	18	nmj	nmj	PROPN
fnp-4366	366	19	model	model	NOUN
fnp-4366	366	20	of	of	ADP
fnp-4366	366	21	neuroinflam	neuroinflam	PROPN
fnp-4366	366	22	-	-	PUNCT
fnp-4366	366	23	mation	mation	PROPN
fnp-4366	366	24	scott	scott	PROPN
fnp-4366	366	25	baver1	baver1	PROPN
fnp-4366	366	26	,	,	PUNCT
fnp-4366	366	27	virginia	virginia	PROPN
fnp-4366	366	28	smith2	smith2	PROPN
fnp-4366	366	29	,	,	PUNCT
fnp-4366	366	30	yan	yan	PROPN
fnp-4366	366	31	li1	li1	PROPN
fnp-4366	366	32	,	,	PUNCT
fnp-4366	366	33	david	david	PROPN
fnp-4366	366	34	eyerman1	eyerman1	PROPN
fnp-4366	366	35	,	,	PUNCT
fnp-4366	366	36	ashley	ashley	PROPN
fnp-4366	366	37	robertson2	robertson2	PROPN
fnp-4366	366	38	,	,	PUNCT
fnp-4366	366	39	leticia	leticia	PROPN
fnp-4366	366	40	lenkiu2	lenkiu2	PROPN
fnp-4366	366	41	,	,	PUNCT
fnp-4366	366	42	heather	heather	NOUN
fnp-4366	366	43	cannon2	cannon2	NOUN
fnp-4366	366	44	,	,	PUNCT
fnp-4366	366	45	daisy	daisy	NOUN
fnp-4366	366	46	martinez2	martinez2	PROPN
fnp-4366	366	47	,	,	PUNCT
fnp-4366	366	48	hannah	hannah	PROPN
fnp-4366	366	49	hanson2	hanson2	PROPN
fnp-4366	366	50	,	,	PUNCT
fnp-4366	366	51	james	james	PROPN
fnp-4366	366	52	hesperos2	hesperos2	PROPN
fnp-4366	366	53	1	1	NUM
fnp-4366	366	54	apellis	apelli	NOUN
fnp-4366	366	55	,	,	PUNCT
fnp-4366	366	56	waltham	waltham	PROPN
fnp-4366	366	57	,	,	PUNCT
fnp-4366	366	58	united	united	PROPN
fnp-4366	366	59	states	states	PROPN
fnp-4366	366	60	2	2	NUM
fnp-4366	366	61	hesperos	hespero	NOUN
fnp-4366	366	62	,	,	PUNCT
fnp-4366	366	63	orlando	orlando	PROPN
fnp-4366	366	64	,	,	PUNCT
fnp-4366	366	65	united	united	PROPN
fnp-4366	366	66	states	states	PROPN
fnp-4366	366	67	background	background	NOUN
fnp-4366	366	68	:	:	PUNCT
fnp-4366	366	69	the	the	DET
fnp-4366	366	70	complement	complement	NOUN
fnp-4366	366	71	cascade	cascade	NOUN
fnp-4366	366	72	is	be	AUX
fnp-4366	366	73	a	a	DET
fnp-4366	366	74	critical	critical	ADJ
fnp-4366	366	75	component	component	NOUN
fnp-4366	366	76	of	of	ADP
fnp-4366	366	77	the	the	DET
fnp-4366	366	78	immune	immune	ADJ
fnp-4366	366	79	system	system	NOUN
fnp-4366	366	80	,	,	PUNCT
fnp-4366	366	81	and	and	CCONJ
fnp-4366	366	82	dysfunction	dysfunction	NOUN
fnp-4366	366	83	of	of	ADP
fnp-4366	366	84	complement	complement	NOUN
fnp-4366	366	85	has	have	AUX
fnp-4366	366	86	been	be	AUX
fnp-4366	366	87	implicated	implicate	VERB
fnp-4366	366	88	in	in	ADP
fnp-4366	366	89	als	al	NOUN
fnp-4366	366	90	.	.	PUNCT
fnp-4366	367	1	components	component	NOUN
fnp-4366	367	2	of	of	ADP
fnp-4366	367	3	the	the	DET
fnp-4366	367	4	complement	complement	NOUN
fnp-4366	367	5	cascade	cascade	NOUN
fnp-4366	367	6	,	,	PUNCT
fnp-4366	367	7	including	include	VERB
fnp-4366	367	8	c3	c3	PROPN
fnp-4366	367	9	,	,	PUNCT
fnp-4366	367	10	are	be	AUX
fnp-4366	367	11	reported	report	VERB
fnp-4366	367	12	to	to	PART
fnp-4366	367	13	be	be	AUX
fnp-4366	367	14	deposited	deposit	VERB
fnp-4366	367	15	on	on	ADP
fnp-4366	367	16	neuromuscular	neuromuscular	ADJ
fnp-4366	367	17	junctions	junction	NOUN
fnp-4366	367	18	(	(	PUNCT
fnp-4366	367	19	nmjs	nmj	NOUN
fnp-4366	367	20	)	)	PUNCT
fnp-4366	367	21	of	of	ADP
fnp-4366	367	22	muscle	muscle	NOUN
fnp-4366	367	23	biopsies	biopsy	NOUN
fnp-4366	367	24	in	in	ADP
fnp-4366	367	25	people	people	NOUN
fnp-4366	367	26	with	with	ADP
fnp-4366	367	27	als	al	NOUN
fnp-4366	367	28	.	.	PUNCT
fnp-4366	368	1	objectives	objective	NOUN
fnp-4366	368	2	:	:	PUNCT
fnp-4366	368	3	evaluate	evaluate	VERB
fnp-4366	368	4	the	the	DET
fnp-4366	368	5	effect	effect	NOUN
fnp-4366	368	6	of	of	ADP
fnp-4366	368	7	complement	complement	NOUN
fnp-4366	368	8	c3	c3	NOUN
fnp-4366	368	9	inhibition	inhibition	NOUN
fnp-4366	368	10	on	on	ADP
fnp-4366	368	11	nmj	nmj	NOUN
fnp-4366	368	12	function	function	NOUN
fnp-4366	368	13	in	in	ADP
fnp-4366	368	14	response	response	NOUN
fnp-4366	368	15	to	to	ADP
fnp-4366	368	16	inflammatory	inflammatory	ADJ
fnp-4366	368	17	stimulations	stimulation	NOUN
fnp-4366	368	18	in	in	ADP
fnp-4366	368	19	a	a	DET
fnp-4366	368	20	human	human	ADJ
fnp-4366	368	21	ipsc	ipsc	NOUN
fnp-4366	368	22	-	-	PUNCT
fnp-4366	368	23	derived	derive	VERB
fnp-4366	368	24	nmj	nmj	NOUN
fnp-4366	368	25	model	model	NOUN
fnp-4366	368	26	.	.	PUNCT
fnp-4366	369	1	question	question	NOUN
fnp-4366	369	2	:	:	PUNCT
fnp-4366	369	3	while	while	SCONJ
fnp-4366	369	4	the	the	DET
fnp-4366	369	5	therapeutic	therapeutic	ADJ
fnp-4366	369	6	potential	potential	NOUN
fnp-4366	369	7	of	of	ADP
fnp-4366	369	8	complement	complement	NOUN
fnp-4366	369	9	system	system	NOUN
fnp-4366	369	10	modulation	modulation	NOUN
fnp-4366	369	11	has	have	AUX
fnp-4366	369	12	been	be	AUX
fnp-4366	369	13	explored	explore	VERB
fnp-4366	369	14	via	via	ADP
fnp-4366	369	15	use	use	NOUN
fnp-4366	369	16	of	of	ADP
fnp-4366	369	17	embryonic	embryonic	ADJ
fnp-4366	369	18	knockout	knockout	NOUN
fnp-4366	369	19	animals	animal	NOUN
fnp-4366	369	20	in	in	ADP
fnp-4366	369	21	als	als	NOUN
fnp-4366	369	22	models	model	NOUN
fnp-4366	369	23	,	,	PUNCT
fnp-4366	369	24	its	its	PRON
fnp-4366	369	25	effects	effect	NOUN
fnp-4366	369	26	in	in	ADP
fnp-4366	369	27	clinically	clinically	ADV
fnp-4366	369	28	relevant	relevant	ADJ
fnp-4366	369	29	human	human	ADJ
fnp-4366	369	30	cell	cell	NOUN
fnp-4366	369	31	-	-	PUNCT
fnp-4366	369	32	based	base	VERB
fnp-4366	369	33	models	model	NOUN
fnp-4366	369	34	are	be	AUX
fnp-4366	369	35	unknown	unknown	ADJ
fnp-4366	369	36	.	.	PUNCT
fnp-4366	370	1	methods	method	NOUN
fnp-4366	370	2	:	:	PUNCT
fnp-4366	370	3	nmj	nmj	NOUN
fnp-4366	370	4	systems	system	NOUN
fnp-4366	370	5	were	be	AUX
fnp-4366	370	6	established	establish	VERB
fnp-4366	370	7	by	by	ADP
fnp-4366	370	8	plating	plate	VERB
fnp-4366	370	9	human	human	ADJ
fnp-4366	370	10	ipsc	ipsc	NOUN
fnp-4366	370	11	-	-	PUNCT
fnp-4366	370	12	derived	derive	VERB
fnp-4366	370	13	motoneurons	motoneuron	NOUN
fnp-4366	370	14	,	,	PUNCT
fnp-4366	370	15	skeletal	skeletal	ADJ
fnp-4366	370	16	myoblasts	myoblast	NOUN
fnp-4366	370	17	,	,	PUNCT
fnp-4366	370	18	schwann	schwann	PROPN
fnp-4366	370	19	cells	cell	NOUN
fnp-4366	370	20	,	,	PUNCT
fnp-4366	370	21	microglia	microglia	ADJ
fnp-4366	370	22	,	,	PUNCT
fnp-4366	370	23	and	and	CCONJ
fnp-4366	370	24	activated	activate	VERB
fnp-4366	370	25	or	or	CCONJ
fnp-4366	370	26	inactivated	inactivated	ADJ
fnp-4366	370	27	thp	thp	PROPN
fnp-4366	370	28	monocytes	monocyte	VERB
fnp-4366	370	29	in	in	ADP
fnp-4366	370	30	a	a	DET
fnp-4366	370	31	compartmentalized	compartmentalized	ADJ
fnp-4366	370	32	co	co	NOUN
fnp-4366	370	33	-	-	NOUN
fnp-4366	370	34	culture	culture	ADJ
fnp-4366	370	35	system	system	NOUN
fnp-4366	370	36	.	.	PUNCT
fnp-4366	371	1	activated	activate	VERB
fnp-4366	371	2	and	and	CCONJ
fnp-4366	371	3	inactivated	inactivated	ADJ
fnp-4366	371	4	monocytes	monocyte	NOUN
fnp-4366	371	5	were	be	AUX
fnp-4366	371	6	plated	plate	VERB
fnp-4366	371	7	at	at	ADP
fnp-4366	371	8	ratios	ratio	NOUN
fnp-4366	371	9	of	of	ADP
fnp-4366	371	10	4:1	4:1	NUM
fnp-4366	371	11	-	-	SYM
fnp-4366	371	12	1:50	1:50	NUM
fnp-4366	371	13	(	(	PUNCT
fnp-4366	371	14	vs.	vs.	ADP
fnp-4366	371	15	skeletal	skeletal	ADJ
fnp-4366	371	16	myoblasts	myoblast	NOUN
fnp-4366	371	17	)	)	PUNCT
fnp-4366	371	18	.	.	PUNCT
fnp-4366	372	1	als	als	VERB
fnp-4366	372	2	model	model	NOUN
fnp-4366	372	3	systems	system	NOUN
fnp-4366	372	4	were	be	AUX
fnp-4366	372	5	created	create	VERB
fnp-4366	372	6	using	use	VERB
fnp-4366	372	7	sod-1	sod-1	ADJ
fnp-4366	372	8	(	(	PUNCT
fnp-4366	372	9	e100	e100	PROPN
fnp-4366	372	10	g	g	NOUN
fnp-4366	372	11	)	)	PUNCT
fnp-4366	372	12	or	or	CCONJ
fnp-4366	372	13	tdp-43	tdp-43	ADP
fnp-4366	372	14	ipsc	ipsc	NOUN
fnp-4366	372	15	-	-	PUNCT
fnp-4366	372	16	derived	derive	VERB
fnp-4366	372	17	cells	cell	NOUN
fnp-4366	372	18	compared	compare	VERB
fnp-4366	372	19	to	to	PART
fnp-4366	372	20	control	control	VERB
fnp-4366	372	21	nmjs	nmj	NOUN
fnp-4366	372	22	established	establish	VERB
fnp-4366	372	23	from	from	ADP
fnp-4366	372	24	wild	wild	ADJ
fnp-4366	372	25	-	-	PUNCT
fnp-4366	372	26	type	type	NOUN
fnp-4366	372	27	ipsc	ipsc	NOUN
fnp-4366	372	28	-	-	PUNCT
fnp-4366	372	29	derived	derive	VERB
fnp-4366	372	30	cells	cell	NOUN
fnp-4366	372	31	.	.	PUNCT
fnp-4366	373	1	to	to	PART
fnp-4366	373	2	determine	determine	VERB
fnp-4366	373	3	the	the	DET
fnp-4366	373	4	role	role	NOUN
fnp-4366	373	5	of	of	ADP
fnp-4366	373	6	c3	c3	PROPN
fnp-4366	373	7	on	on	ADP
fnp-4366	373	8	nmj	nmj	PROPN
fnp-4366	373	9	function	function	NOUN
fnp-4366	373	10	,	,	PUNCT
fnp-4366	373	11	the	the	DET
fnp-4366	373	12	c3	c3	PROPN
fnp-4366	373	13	inhibitor	inhibitor	NOUN
fnp-4366	373	14	apl-2	apl-2	PUNCT
fnp-4366	373	15	(	(	PUNCT
fnp-4366	373	16	50	50	NUM
fnp-4366	373	17	µg	µg	NOUN
fnp-4366	373	18	/	/	SYM
fnp-4366	373	19	ml	ml	NOUN
fnp-4366	373	20	)	)	PUNCT
fnp-4366	373	21	and	and	CCONJ
fnp-4366	373	22	human	human	ADJ
fnp-4366	373	23	complement	complement	NOUN
fnp-4366	373	24	serum	serum	NOUN
fnp-4366	373	25	(	(	PUNCT
fnp-4366	373	26	0.05	0.05	NUM
fnp-4366	373	27	%	%	NOUN
fnp-4366	373	28	)	)	PUNCT
fnp-4366	373	29	were	be	AUX
fnp-4366	373	30	acutely	acutely	ADV
fnp-4366	373	31	dosed	dose	VERB
fnp-4366	373	32	for	for	ADP
fnp-4366	373	33	3	3	NUM
fnp-4366	373	34	hours	hour	NOUN
fnp-4366	373	35	.	.	PUNCT
fnp-4366	374	1	complement	complement	NOUN
fnp-4366	374	2	c3	c3	PROPN
fnp-4366	374	3	expression	expression	NOUN
fnp-4366	374	4	was	be	AUX
fnp-4366	374	5	assessed	assess	VERB
fnp-4366	374	6	by	by	ADP
fnp-4366	374	7	immunocytochemistry	immunocytochemistry	NOUN
fnp-4366	374	8	,	,	PUNCT
fnp-4366	374	9	and	and	CCONJ
fnp-4366	374	10	nmj	nmj	NOUN
fnp-4366	374	11	number	number	NOUN
fnp-4366	374	12	and	and	CCONJ
fnp-4366	374	13	fidelity	fidelity	NOUN
fnp-4366	374	14	were	be	AUX
fnp-4366	374	15	calculated	calculate	VERB
fnp-4366	374	16	by	by	ADP
fnp-4366	374	17	assessing	assess	VERB
fnp-4366	374	18	the	the	DET
fnp-4366	374	19	number	number	NOUN
fnp-4366	374	20	of	of	ADP
fnp-4366	374	21	functional	functional	ADJ
fnp-4366	374	22	myotubes	myotube	NOUN
fnp-4366	374	23	under	under	ADP
fnp-4366	374	24	indirect	indirect	ADJ
fnp-4366	374	25	stimulation	stimulation	NOUN
fnp-4366	374	26	and	and	CCONJ
fnp-4366	374	27	the	the	DET
fnp-4366	374	28	ratio	ratio	NOUN
fnp-4366	374	29	of	of	ADP
fnp-4366	374	30	number	number	NOUN
fnp-4366	374	31	of	of	ADP
fnp-4366	374	32	successful	successful	ADJ
fnp-4366	374	33	contractions	contraction	NOUN
fnp-4366	374	34	to	to	ADP
fnp-4366	374	35	number	number	NOUN
fnp-4366	374	36	of	of	ADP
fnp-4366	374	37	pulses	pulse	NOUN
fnp-4366	374	38	at	at	ADP
fnp-4366	374	39	a	a	DET
fnp-4366	374	40	given	give	VERB
fnp-4366	374	41	frequency	frequency	NOUN
fnp-4366	374	42	,	,	PUNCT
fnp-4366	374	43	respectively	respectively	ADV
fnp-4366	374	44	.	.	PUNCT
fnp-4366	375	1	all	all	DET
fnp-4366	375	2	experiments	experiment	NOUN
fnp-4366	375	3	were	be	AUX
fnp-4366	375	4	replicated	replicate	VERB
fnp-4366	375	5	twice	twice	ADV
fnp-4366	375	6	in	in	ADP
fnp-4366	375	7	triplicate	triplicate	NOUN
fnp-4366	375	8	.	.	PUNCT
fnp-4366	376	1	results	result	NOUN
fnp-4366	376	2	:	:	PUNCT
fnp-4366	376	3	functional	functional	ADJ
fnp-4366	376	4	nmj	nmj	NOUN
fnp-4366	376	5	systems	system	NOUN
fnp-4366	376	6	were	be	AUX
fnp-4366	376	7	assessed	assess	VERB
fnp-4366	376	8	with	with	ADP
fnp-4366	376	9	the	the	DET
fnp-4366	376	10	addition	addition	NOUN
fnp-4366	376	11	of	of	ADP
fnp-4366	376	12	various	various	ADJ
fnp-4366	376	13	ratios	ratio	NOUN
fnp-4366	376	14	of	of	ADP
fnp-4366	376	15	activated	activate	VERB
fnp-4366	376	16	or	or	CCONJ
fnp-4366	376	17	inactivated	inactivated	ADJ
fnp-4366	376	18	monocytes	monocyte	NOUN
fnp-4366	376	19	to	to	ADP
fnp-4366	376	20	skeletal	skeletal	ADJ
fnp-4366	376	21	muscle	muscle	NOUN
fnp-4366	376	22	-	-	PUNCT
fnp-4366	376	23	side	side	NOUN
fnp-4366	376	24	of	of	ADP
fnp-4366	376	25	the	the	DET
fnp-4366	376	26	culture	culture	NOUN
fnp-4366	376	27	chamber	chamber	PROPN
fnp-4366	376	28	.	.	PUNCT
fnp-4366	377	1	addition	addition	NOUN
fnp-4366	377	2	of	of	ADP
fnp-4366	377	3	activated	activated	ADJ
fnp-4366	377	4	monocytes	monocyte	NOUN
fnp-4366	377	5	resulted	result	VERB
fnp-4366	377	6	in	in	ADP
fnp-4366	377	7	reduced	reduce	VERB
fnp-4366	377	8	nmj	nmj	NOUN
fnp-4366	377	9	number	number	NOUN
fnp-4366	377	10	and	and	CCONJ
fnp-4366	377	11	function	function	NOUN
fnp-4366	377	12	.	.	PUNCT
fnp-4366	378	1	in	in	ADP
fnp-4366	378	2	addition	addition	NOUN
fnp-4366	378	3	,	,	PUNCT
fnp-4366	378	4	while	while	SCONJ
fnp-4366	378	5	c3	c3	NOUN
fnp-4366	378	6	expression	expression	NOUN
fnp-4366	378	7	was	be	AUX
fnp-4366	378	8	observed	observe	VERB
fnp-4366	378	9	with	with	ADP
fnp-4366	378	10	thp	thp	PROPN
fnp-4366	378	11	-	-	PUNCT
fnp-4366	378	12	monocytes	monocyte	NOUN
fnp-4366	378	13	,	,	PUNCT
fnp-4366	378	14	activation	activation	NOUN
fnp-4366	378	15	of	of	ADP
fnp-4366	378	16	m1	m1	NOUN
fnp-4366	378	17	macrophages	macrophage	NOUN
fnp-4366	378	18	increased	increase	VERB
fnp-4366	378	19	c3	c3	NOUN
fnp-4366	378	20	activity	activity	NOUN
fnp-4366	378	21	.	.	PUNCT
fnp-4366	379	1	human	human	ADJ
fnp-4366	379	2	complement	complement	NOUN
fnp-4366	379	3	serum	serum	NOUN
fnp-4366	379	4	potentiated	potentiate	VERB
fnp-4366	379	5	the	the	DET
fnp-4366	379	6	effects	effect	NOUN
fnp-4366	379	7	of	of	ADP
fnp-4366	379	8	m1	m1	NOUN
fnp-4366	379	9	macrophages	macrophage	NOUN
fnp-4366	379	10	;	;	PUNCT
fnp-4366	379	11	further	far	ADV
fnp-4366	379	12	decreasing	decrease	VERB
fnp-4366	379	13	nmj	nmj	NOUN
fnp-4366	379	14	numbers	number	NOUN
fnp-4366	379	15	and	and	CCONJ
fnp-4366	379	16	reducing	reduce	VERB
fnp-4366	379	17	nmj	nmj	NOUN
fnp-4366	379	18	fidelity	fidelity	NOUN
fnp-4366	379	19	.	.	PUNCT
fnp-4366	380	1	acute	acute	ADJ
fnp-4366	380	2	treatment	treatment	NOUN
fnp-4366	380	3	with	with	ADP
fnp-4366	380	4	apl-2	apl-2	PUNCT
fnp-4366	380	5	attenuated	attenuate	VERB
fnp-4366	380	6	these	these	DET
fnp-4366	380	7	effects	effect	NOUN
fnp-4366	380	8	.	.	PUNCT
fnp-4366	381	1	compared	compare	VERB
fnp-4366	381	2	to	to	ADP
fnp-4366	381	3	wild	wild	ADJ
fnp-4366	381	4	-	-	PUNCT
fnp-4366	381	5	type	type	NOUN
fnp-4366	381	6	,	,	PUNCT
fnp-4366	381	7	sod-1	sod-1	ADJ
fnp-4366	381	8	and	and	CCONJ
fnp-4366	381	9	tdp-43	tdp-43	PROPN
fnp-4366	381	10	nmj	nmj	NOUN
fnp-4366	381	11	systems	system	NOUN
fnp-4366	381	12	reduced	reduce	VERB
fnp-4366	381	13	nmj	nmj	NOUN
fnp-4366	381	14	number	number	NOUN
fnp-4366	381	15	and	and	CCONJ
fnp-4366	381	16	fidelity	fidelity	NOUN
fnp-4366	381	17	.	.	PUNCT
fnp-4366	382	1	the	the	DET
fnp-4366	382	2	reduction	reduction	NOUN
fnp-4366	382	3	in	in	ADP
fnp-4366	382	4	sod-1	sod-1	PUNCT
fnp-4366	382	5	nmj	nmj	NOUN
fnp-4366	382	6	number	number	NOUN
fnp-4366	382	7	and	and	CCONJ
fnp-4366	382	8	fidelity	fidelity	NOUN
fnp-4366	382	9	was	be	AUX
fnp-4366	382	10	greater	great	ADJ
fnp-4366	382	11	than	than	ADP
fnp-4366	382	12	that	that	PRON
fnp-4366	382	13	of	of	ADP
fnp-4366	382	14	tdp-43	tdp-43	PROPN
fnp-4366	382	15	nmj	nmj	NOUN
fnp-4366	382	16	system	system	NOUN
fnp-4366	382	17	.	.	PUNCT
fnp-4366	383	1	conclusions	conclusion	NOUN
fnp-4366	383	2	:	:	PUNCT
fnp-4366	383	3	these	these	DET
fnp-4366	383	4	data	datum	NOUN
fnp-4366	383	5	demonstrate	demonstrate	VERB
fnp-4366	383	6	that	that	SCONJ
fnp-4366	383	7	modulating	modulate	VERB
fnp-4366	383	8	c3	c3	NOUN
fnp-4366	383	9	with	with	ADP
fnp-4366	383	10	apl-2	apl-2	PUNCT
fnp-4366	383	11	in	in	ADP
fnp-4366	383	12	the	the	DET
fnp-4366	383	13	presence	presence	NOUN
fnp-4366	383	14	of	of	ADP
fnp-4366	383	15	an	an	DET
fnp-4366	383	16	inflammatory	inflammatory	ADJ
fnp-4366	383	17	nmj	nmj	NOUN
fnp-4366	383	18	environment	environment	NOUN
fnp-4366	383	19	could	could	AUX
fnp-4366	383	20	improve	improve	VERB
fnp-4366	383	21	overall	overall	ADJ
fnp-4366	383	22	function	function	NOUN
fnp-4366	383	23	of	of	ADP
fnp-4366	383	24	the	the	DET
fnp-4366	383	25	nmj	nmj	NOUN
fnp-4366	383	26	in	in	ADP
fnp-4366	383	27	related	relate	VERB
fnp-4366	383	28	disease	disease	NOUN
fnp-4366	383	29	states	state	NOUN
fnp-4366	383	30	.	.	PUNCT
fnp-4366	383	31	  	  	SPACE
fnp-4366	384	1	3.05	3.05	NUM
fnp-4366	384	2	free	free	ADJ
fnp-4366	384	3	neuropathol	neuropathol	NOUN
fnp-4366	384	4	3:20:40	3:20:40	NUM
fnp-4366	384	5	fast	fast	ADJ
fnp-4366	384	6	-	-	PUNCT
fnp-4366	384	7	track	track	NOUN
fnp-4366	384	8	procedure	procedure	NOUN
fnp-4366	384	9	for	for	ADP
fnp-4366	384	10	the	the	DET
fnp-4366	384	11	neuropathological	neuropathological	ADJ
fnp-4366	384	12	assessment	assessment	NOUN
fnp-4366	384	13	of	of	ADP
fnp-4366	384	14	neurodegenerative	neurodegenerative	ADJ
fnp-4366	384	15	diseases	disease	NOUN
fnp-4366	384	16	benjamin	benjamin	PROPN
fnp-4366	384	17	englert1,2,3	englert1,2,3	PROPN
fnp-4366	384	18	,	,	PUNCT
fnp-4366	384	19	viktoria	viktoria	PROPN
fnp-4366	384	20	ruf1	ruf1	PROPN
fnp-4366	384	21	,	,	PUNCT
fnp-4366	384	22	jochen	jochen	PROPN
fnp-4366	384	23	herms1,2,3	herms1,2,3	PROPN
fnp-4366	384	24	1	1	NUM
fnp-4366	384	25	ludwig	ludwig	PROPN
fnp-4366	384	26	-	-	PUNCT
fnp-4366	384	27	maximilians	maximilians	PROPN
fnp-4366	384	28	university	university	NOUN
fnp-4366	384	29	,	,	PUNCT
fnp-4366	384	30	center	center	NOUN
fnp-4366	384	31	for	for	ADP
fnp-4366	384	32	neuropathology	neuropathology	NOUN
fnp-4366	384	33	and	and	CCONJ
fnp-4366	384	34	prion	prion	NOUN
fnp-4366	384	35	research	research	NOUN
fnp-4366	384	36	,	,	PUNCT
fnp-4366	384	37	munich	munich	PROPN
fnp-4366	384	38	,	,	PUNCT
fnp-4366	384	39	deutschland	deutschland	NOUN
fnp-4366	384	40	2	2	NUM
fnp-4366	384	41	german	german	ADJ
fnp-4366	384	42	center	center	NOUN
fnp-4366	384	43	for	for	ADP
fnp-4366	384	44	neurodegenerative	neurodegenerative	ADJ
fnp-4366	384	45	diseases	disease	NOUN
fnp-4366	384	46	(	(	PUNCT
fnp-4366	384	47	dzne	dzne	NOUN
fnp-4366	384	48	)	)	PUNCT
fnp-4366	384	49	,	,	PUNCT
fnp-4366	384	50	munich	munich	PROPN
fnp-4366	384	51	,	,	PUNCT
fnp-4366	384	52	deutschland	deutschland	PROPN
fnp-4366	384	53	3	3	NUM
fnp-4366	384	54	munich	munich	PROPN
fnp-4366	384	55	cluster	cluster	NOUN
fnp-4366	384	56	for	for	ADP
fnp-4366	384	57	systems	system	NOUN
fnp-4366	384	58	neurology	neurology	NOUN
fnp-4366	384	59	(	(	PUNCT
fnp-4366	384	60	synergy	synergy	NOUN
fnp-4366	384	61	)	)	PUNCT
fnp-4366	384	62	,	,	PUNCT
fnp-4366	384	63	munich	munich	PROPN
fnp-4366	384	64	,	,	PUNCT
fnp-4366	384	65	deutschland	deutschland	NOUN
fnp-4366	384	66	background	background	NOUN
fnp-4366	384	67	:	:	PUNCT
fnp-4366	384	68	in	in	ADP
fnp-4366	384	69	order	order	NOUN
fnp-4366	384	70	to	to	PART
fnp-4366	384	71	exclude	exclude	VERB
fnp-4366	384	72	creutzfeldt	creutzfeldt	ADJ
fnp-4366	384	73	-	-	PUNCT
fnp-4366	384	74	jakob	jakob	ADJ
fnp-4366	384	75	disease	disease	NOUN
fnp-4366	384	76	we	we	PRON
fnp-4366	384	77	have	have	AUX
fnp-4366	384	78	established	establish	VERB
fnp-4366	384	79	a	a	DET
fnp-4366	384	80	fast	fast	ADJ
fnp-4366	384	81	-	-	PUNCT
fnp-4366	384	82	track	track	NOUN
fnp-4366	384	83	assessment	assessment	NOUN
fnp-4366	384	84	of	of	ADP
fnp-4366	384	85	all	all	DET
fnp-4366	384	86	brains	brain	NOUN
fnp-4366	384	87	that	that	PRON
fnp-4366	384	88	we	we	PRON
fnp-4366	384	89	receive	receive	VERB
fnp-4366	384	90	at	at	ADP
fnp-4366	384	91	the	the	DET
fnp-4366	384	92	neurobiobank	neurobiobank	PROPN
fnp-4366	384	93	munich	munich	PROPN
fnp-4366	384	94	.	.	PUNCT
fnp-4366	385	1	aims	aim	NOUN
fnp-4366	385	2	and	and	CCONJ
fnp-4366	385	3	questions	question	NOUN
fnp-4366	385	4	:	:	PUNCT
fnp-4366	385	5	we	we	PRON
fnp-4366	385	6	aim	aim	VERB
fnp-4366	385	7	to	to	PART
fnp-4366	385	8	evaluate	evaluate	VERB
fnp-4366	385	9	the	the	DET
fnp-4366	385	10	concordance	concordance	NOUN
fnp-4366	385	11	between	between	ADP
fnp-4366	385	12	fast	fast	ADJ
fnp-4366	385	13	-	-	PUNCT
fnp-4366	385	14	track	track	NOUN
fnp-4366	385	15	working	work	VERB
fnp-4366	385	16	diagnosis	diagnosis	NOUN
fnp-4366	385	17	and	and	CCONJ
fnp-4366	385	18	the	the	DET
fnp-4366	385	19	full	full	ADJ
fnp-4366	385	20	histological	histological	ADJ
fnp-4366	385	21	work	work	NOUN
fnp-4366	385	22	-	-	PUNCT
fnp-4366	385	23	up	up	NOUN
fnp-4366	385	24	of	of	ADP
fnp-4366	385	25	the	the	DET
fnp-4366	385	26	brain	brain	NOUN
fnp-4366	385	27	of	of	ADP
fnp-4366	385	28	patients	patient	NOUN
fnp-4366	385	29	clinically	clinically	ADV
fnp-4366	385	30	diagnosed	diagnose	VERB
fnp-4366	385	31	with	with	ADP
fnp-4366	385	32	a	a	DET
fnp-4366	385	33	neurodegenerative	neurodegenerative	ADJ
fnp-4366	385	34	disease	disease	NOUN
fnp-4366	385	35	.	.	PUNCT
fnp-4366	386	1	methods	method	NOUN
fnp-4366	386	2	:	:	PUNCT
fnp-4366	386	3	two	two	NUM
fnp-4366	386	4	predefined	predefine	VERB
fnp-4366	386	5	,	,	PUNCT
fnp-4366	386	6	easily	easily	ADV
fnp-4366	386	7	accessible	accessible	ADJ
fnp-4366	386	8	brain	brain	NOUN
fnp-4366	386	9	regions	region	NOUN
fnp-4366	386	10	(	(	PUNCT
fnp-4366	386	11	frontal	frontal	ADJ
fnp-4366	386	12	superior	superior	ADJ
fnp-4366	386	13	gyrus	gyrus	NOUN
fnp-4366	386	14	and	and	CCONJ
fnp-4366	386	15	cerebellar	cerebellar	PROPN
fnp-4366	386	16	hemisphere	hemisphere	ADV
fnp-4366	386	17	)	)	PUNCT
fnp-4366	386	18	were	be	AUX
fnp-4366	386	19	sampled	sample	VERB
fnp-4366	386	20	,	,	PUNCT
fnp-4366	386	21	fixed	fix	VERB
fnp-4366	386	22	in	in	ADP
fnp-4366	386	23	formalin	formalin	NOUN
fnp-4366	386	24	,	,	PUNCT
fnp-4366	386	25	treated	treat	VERB
fnp-4366	386	26	with	with	ADP
fnp-4366	386	27	formic	formic	ADJ
fnp-4366	386	28	acid	acid	NOUN
fnp-4366	386	29	and	and	CCONJ
fnp-4366	386	30	embedded	embed	VERB
fnp-4366	386	31	together	together	ADV
fnp-4366	386	32	in	in	ADP
fnp-4366	386	33	one	one	NUM
fnp-4366	386	34	paraffin	paraffin	NOUN
fnp-4366	386	35	block	block	NOUN
fnp-4366	386	36	.	.	PUNCT
fnp-4366	387	1	h&e	h&e	PROPN
fnp-4366	387	2	stain	stain	NOUN
fnp-4366	387	3	and	and	CCONJ
fnp-4366	387	4	six	six	NUM
fnp-4366	387	5	immunostains	immunostain	NOUN
fnp-4366	387	6	(	(	PUNCT
fnp-4366	387	7	antibodies	antibodie	VERB
fnp-4366	387	8	against	against	ADP
fnp-4366	387	9	prion	prion	NOUN
fnp-4366	387	10	protein	protein	NOUN
fnp-4366	387	11	,	,	PUNCT
fnp-4366	387	12	α	α	NOUN
fnp-4366	387	13	-	-	PUNCT
fnp-4366	387	14	synuclein	synuclein	NOUN
fnp-4366	387	15	,	,	PUNCT
fnp-4366	387	16	β	β	NOUN
fnp-4366	387	17	-	-	NOUN
fnp-4366	387	18	amyloid	amyloid	ADJ
fnp-4366	387	19	,	,	PUNCT
fnp-4366	387	20	phospho	phospho	NOUN
fnp-4366	387	21	-	-	PUNCT
fnp-4366	387	22	tau	tau	NOUN
fnp-4366	387	23	,	,	PUNCT
fnp-4366	387	24	phospho	phospho	NOUN
fnp-4366	387	25	-	-	PUNCT
fnp-4366	387	26	tdp43	tdp43	NOUN
fnp-4366	387	27	,	,	PUNCT
fnp-4366	387	28	p62	p62	NOUN
fnp-4366	387	29	)	)	PUNCT
fnp-4366	387	30	were	be	AUX
fnp-4366	387	31	performed	perform	VERB
fnp-4366	387	32	.	.	PUNCT
fnp-4366	388	1	133	133	NUM
fnp-4366	388	2	cases	case	NOUN
fnp-4366	388	3	were	be	AUX
fnp-4366	388	4	analysed	analyse	VERB
fnp-4366	388	5	.	.	PUNCT
fnp-4366	389	1	diseases	disease	NOUN
fnp-4366	389	2	in	in	ADP
fnp-4366	389	3	which	which	PRON
fnp-4366	389	4	a	a	DET
fnp-4366	389	5	diagnosis	diagnosis	NOUN
fnp-4366	389	6	can	can	AUX
fnp-4366	389	7	not	not	PART
fnp-4366	389	8	be	be	AUX
fnp-4366	389	9	made	make	VERB
fnp-4366	389	10	by	by	ADP
fnp-4366	389	11	analysing	analyse	VERB
fnp-4366	389	12	these	these	DET
fnp-4366	389	13	two	two	NUM
fnp-4366	389	14	brain	brain	NOUN
fnp-4366	389	15	regions	region	NOUN
fnp-4366	389	16	like	like	ADP
fnp-4366	389	17	pure	pure	ADJ
fnp-4366	389	18	amyotrophic	amyotrophic	ADJ
fnp-4366	389	19	lateral	lateral	ADJ
fnp-4366	389	20	sclerosis	sclerosis	NOUN
fnp-4366	389	21	and	and	CCONJ
fnp-4366	389	22	huntington	huntington	PROPN
fnp-4366	389	23	disease	disease	NOUN
fnp-4366	389	24	have	have	AUX
fnp-4366	389	25	been	be	AUX
fnp-4366	389	26	excluded	exclude	VERB
fnp-4366	389	27	from	from	ADP
fnp-4366	389	28	this	this	DET
fnp-4366	389	29	analysis	analysis	NOUN
fnp-4366	389	30	.	.	PUNCT
fnp-4366	390	1	results	result	NOUN
fnp-4366	390	2	:	:	PUNCT
fnp-4366	390	3	in	in	ADP
fnp-4366	390	4	96.2	96.2	NUM
fnp-4366	390	5	%	%	NOUN
fnp-4366	390	6	of	of	ADP
fnp-4366	390	7	cases	case	NOUN
fnp-4366	390	8	the	the	DET
fnp-4366	390	9	fast	fast	ADJ
fnp-4366	390	10	-	-	PUNCT
fnp-4366	390	11	track	track	NOUN
fnp-4366	390	12	neuropathological	neuropathological	ADJ
fnp-4366	390	13	diagnosis	diagnosis	NOUN
fnp-4366	390	14	was	be	AUX
fnp-4366	390	15	confirmed	confirm	VERB
fnp-4366	390	16	by	by	ADP
fnp-4366	390	17	the	the	DET
fnp-4366	390	18	conventional	conventional	ADJ
fnp-4366	390	19	pathological	pathological	ADJ
fnp-4366	390	20	work	work	NOUN
fnp-4366	390	21	-	-	PUNCT
fnp-4366	390	22	up	up	NOUN
fnp-4366	390	23	of	of	ADP
fnp-4366	390	24	the	the	DET
fnp-4366	390	25	entire	entire	ADJ
fnp-4366	390	26	brain	brain	NOUN
fnp-4366	390	27	.	.	PUNCT
fnp-4366	391	1	only	only	ADV
fnp-4366	391	2	in	in	ADP
fnp-4366	391	3	four	four	NUM
fnp-4366	391	4	cases	case	NOUN
fnp-4366	391	5	evaluation	evaluation	NOUN
fnp-4366	391	6	of	of	ADP
fnp-4366	391	7	additional	additional	ADJ
fnp-4366	391	8	brain	brain	NOUN
fnp-4366	391	9	regions	region	NOUN
fnp-4366	391	10	was	be	AUX
fnp-4366	391	11	necessary	necessary	ADJ
fnp-4366	391	12	to	to	PART
fnp-4366	391	13	make	make	VERB
fnp-4366	391	14	a	a	DET
fnp-4366	391	15	conclusive	conclusive	ADJ
fnp-4366	391	16	histopathological	histopathological	ADJ
fnp-4366	391	17	diagnosis	diagnosis	NOUN
fnp-4366	391	18	.	.	PUNCT
fnp-4366	392	1	only	only	ADV
fnp-4366	392	2	in	in	ADP
fnp-4366	392	3	one	one	NUM
fnp-4366	392	4	case	case	NOUN
fnp-4366	392	5	in	in	ADP
fnp-4366	392	6	our	our	PRON
fnp-4366	392	7	study	study	NOUN
fnp-4366	392	8	(	(	PUNCT
fnp-4366	392	9	of	of	ADP
fnp-4366	392	10	an	an	DET
fnp-4366	392	11	unusual	unusual	ADJ
fnp-4366	392	12	tauopathy	tauopathy	NOUN
fnp-4366	392	13	)	)	PUNCT
fnp-4366	392	14	the	the	DET
fnp-4366	392	15	fast	fast	ADJ
fnp-4366	392	16	-	-	PUNCT
fnp-4366	392	17	track	track	NOUN
fnp-4366	392	18	diagnosis	diagnosis	NOUN
fnp-4366	392	19	needed	need	VERB
fnp-4366	392	20	to	to	PART
fnp-4366	392	21	be	be	AUX
fnp-4366	392	22	corrected	correct	VERB
fnp-4366	392	23	.	.	PUNCT
fnp-4366	393	1	the	the	DET
fnp-4366	393	2	suspected	suspect	VERB
fnp-4366	393	3	clinical	clinical	ADJ
fnp-4366	393	4	diagnosis	diagnosis	NOUN
fnp-4366	393	5	was	be	AUX
fnp-4366	393	6	neuropathologically	neuropathologically	ADV
fnp-4366	393	7	confirmed	confirm	VERB
fnp-4366	393	8	by	by	ADP
fnp-4366	393	9	fast	fast	ADJ
fnp-4366	393	10	-	-	PUNCT
fnp-4366	393	11	track	track	NOUN
fnp-4366	393	12	histology	histology	NOUN
fnp-4366	393	13	in	in	ADP
fnp-4366	393	14	only	only	ADV
fnp-4366	393	15	60.2	60.2	NUM
fnp-4366	393	16	%	%	NOUN
fnp-4366	393	17	of	of	ADP
fnp-4366	393	18	cases	case	NOUN
fnp-4366	393	19	.	.	PUNCT
fnp-4366	394	1	in	in	ADP
fnp-4366	394	2	39.8	39.8	NUM
fnp-4366	394	3	%	%	NOUN
fnp-4366	394	4	the	the	DET
fnp-4366	394	5	clinical	clinical	ADJ
fnp-4366	394	6	diagnosis	diagnosis	NOUN
fnp-4366	394	7	was	be	AUX
fnp-4366	394	8	either	either	CCONJ
fnp-4366	394	9	different	different	ADJ
fnp-4366	394	10	or	or	CCONJ
fnp-4366	394	11	ambiguous	ambiguous	ADJ
fnp-4366	394	12	.	.	PUNCT
fnp-4366	395	1	conclusion	conclusion	NOUN
fnp-4366	395	2	:	:	PUNCT
fnp-4366	395	3	our	our	PRON
fnp-4366	395	4	study	study	NOUN
fnp-4366	395	5	shows	show	VERB
fnp-4366	395	6	that	that	SCONJ
fnp-4366	395	7	histological	histological	ADJ
fnp-4366	395	8	and	and	CCONJ
fnp-4366	395	9	immunohistochemical	immunohistochemical	ADJ
fnp-4366	395	10	screening	screening	NOUN
fnp-4366	395	11	of	of	ADP
fnp-4366	395	12	two	two	NUM
fnp-4366	395	13	selected	select	VERB
fnp-4366	395	14	brain	brain	NOUN
fnp-4366	395	15	regions	region	NOUN
fnp-4366	395	16	(	(	PUNCT
fnp-4366	395	17	superior	superior	ADJ
fnp-4366	395	18	frontal	frontal	ADJ
fnp-4366	395	19	gyrus	gyrus	NOUN
fnp-4366	395	20	and	and	CCONJ
fnp-4366	395	21	cerebellum	cerebellum	NOUN
fnp-4366	395	22	)	)	PUNCT
fnp-4366	395	23	is	be	AUX
fnp-4366	395	24	indeed	indeed	ADV
fnp-4366	395	25	sufficient	sufficient	ADJ
fnp-4366	395	26	for	for	ADP
fnp-4366	395	27	establishing	establish	VERB
fnp-4366	395	28	a	a	DET
fnp-4366	395	29	reliable	reliable	ADJ
fnp-4366	395	30	working	working	NOUN
fnp-4366	395	31	diagnosis	diagnosis	NOUN
fnp-4366	395	32	of	of	ADP
fnp-4366	395	33	patients	patient	NOUN
fnp-4366	395	34	with	with	ADP
fnp-4366	395	35	a	a	DET
fnp-4366	395	36	neurodegenerative	neurodegenerative	ADJ
fnp-4366	395	37	disease	disease	NOUN
fnp-4366	395	38	in	in	ADP
fnp-4366	395	39	over	over	ADP
fnp-4366	395	40	96	96	NUM
fnp-4366	395	41	%	%	NOUN
fnp-4366	395	42	of	of	ADP
fnp-4366	395	43	cases	case	NOUN
fnp-4366	395	44	.	.	PUNCT
fnp-4366	396	1	given	give	VERB
fnp-4366	396	2	the	the	DET
fnp-4366	396	3	rapid	rapid	ADJ
fnp-4366	396	4	workflow	workflow	NOUN
fnp-4366	396	5	,	,	PUNCT
fnp-4366	396	6	a	a	DET
fnp-4366	396	7	prompt	prompt	ADJ
fnp-4366	396	8	response	response	NOUN
fnp-4366	396	9	from	from	ADP
fnp-4366	396	10	the	the	DET
fnp-4366	396	11	neuropathology	neuropathology	NOUN
fnp-4366	396	12	to	to	ADP
fnp-4366	396	13	clinicians	clinician	NOUN
fnp-4366	396	14	may	may	AUX
fnp-4366	396	15	improve	improve	VERB
fnp-4366	396	16	the	the	DET
fnp-4366	396	17	accuracy	accuracy	NOUN
fnp-4366	396	18	of	of	ADP
fnp-4366	396	19	clinical	clinical	ADJ
fnp-4366	396	20	diagnosis	diagnosis	NOUN
fnp-4366	396	21	.	.	PUNCT
fnp-4366	397	1	this	this	DET
fnp-4366	397	2	procedure	procedure	NOUN
fnp-4366	397	3	does	do	AUX
fnp-4366	397	4	not	not	PART
fnp-4366	397	5	allow	allow	VERB
fnp-4366	397	6	precise	precise	ADJ
fnp-4366	397	7	neuropathological	neuropathological	ADJ
fnp-4366	397	8	disease	disease	NOUN
fnp-4366	397	9	staging	staging	NOUN
fnp-4366	397	10	and	and	CCONJ
fnp-4366	397	11	certain	certain	ADJ
fnp-4366	397	12	co	co	NOUN
fnp-4366	397	13	-	-	NOUN
fnp-4366	397	14	pathology	pathology	NOUN
fnp-4366	397	15	can	can	AUX
fnp-4366	397	16	not	not	PART
fnp-4366	397	17	be	be	AUX
fnp-4366	397	18	fully	fully	ADV
fnp-4366	397	19	appraised	appraise	VERB
fnp-4366	397	20	.	.	PUNCT
fnp-4366	398	1	diseases	disease	NOUN
fnp-4366	398	2	like	like	ADP
fnp-4366	398	3	pure	pure	ADJ
fnp-4366	398	4	als	al	NOUN
fnp-4366	398	5	or	or	CCONJ
fnp-4366	398	6	hd	hd	NOUN
fnp-4366	398	7	can	can	AUX
fnp-4366	398	8	not	not	PART
fnp-4366	398	9	be	be	AUX
fnp-4366	398	10	neuropathologically	neuropathologically	ADV
fnp-4366	398	11	verified	verify	VERB
fnp-4366	398	12	on	on	ADP
fnp-4366	398	13	these	these	DET
fnp-4366	398	14	two	two	NUM
fnp-4366	398	15	brain	brain	NOUN
fnp-4366	398	16	regions	region	NOUN
fnp-4366	398	17	and	and	CCONJ
fnp-4366	398	18	the	the	DET
fnp-4366	398	19	contribution	contribution	NOUN
fnp-4366	398	20	of	of	ADP
fnp-4366	398	21	vascular	vascular	ADJ
fnp-4366	398	22	pathology	pathology	NOUN
fnp-4366	398	23	to	to	ADP
fnp-4366	398	24	the	the	DET
fnp-4366	398	25	clinical	clinical	ADJ
fnp-4366	398	26	picture	picture	NOUN
fnp-4366	398	27	can	can	AUX
fnp-4366	398	28	not	not	PART
fnp-4366	398	29	be	be	AUX
fnp-4366	398	30	precisely	precisely	ADV
fnp-4366	398	31	assessed	assess	VERB
fnp-4366	398	32	.	.	PUNCT
fnp-4366	398	33	  	  	SPACE
fnp-4366	398	34	3.06	3.06	NUM
fnp-4366	398	35	free	free	ADJ
fnp-4366	398	36	neuropathol	neuropathol	NOUN
fnp-4366	398	37	3:20:41	3:20:41	NUM
fnp-4366	398	38	neurodegeneration	neurodegeneration	NOUN
fnp-4366	398	39	in	in	ADP
fnp-4366	398	40	hsan1	hsan1	NOUN
fnp-4366	398	41	due	due	ADP
fnp-4366	398	42	to	to	ADP
fnp-4366	398	43	atl1	atl1	PROPN
fnp-4366	398	44	(	(	PUNCT
fnp-4366	398	45	gly66gln	gly66gln	PROPN
fnp-4366	398	46	)	)	PUNCT
fnp-4366	398	47	mutation	mutation	NOUN
fnp-4366	398	48	is	be	AUX
fnp-4366	398	49	associated	associate	VERB
fnp-4366	398	50	with	with	ADP
fnp-4366	398	51	defective	defective	ADJ
fnp-4366	398	52	erprotein	erprotein	NOUN
fnp-4366	398	53	quality	quality	NOUN
fnp-4366	398	54	control	control	NOUN
fnp-4366	398	55	and	and	CCONJ
fnp-4366	398	56	compromised	compromise	VERB
fnp-4366	398	57	autophagy	autophagy	ADJ
fnp-4366	398	58	istvan	istvan	PROPN
fnp-4366	398	59	katona1	katona1	PROPN
fnp-4366	398	60	,	,	PUNCT
fnp-4366	398	61	hülya	hülya	NOUN
fnp-4366	398	62	-	-	PUNCT
fnp-4366	398	63	sevcan	sevcan	PROPN
fnp-4366	398	64	daimagüler2	daimagüler2	PROPN
fnp-4366	398	65	,	,	PUNCT
fnp-4366	398	66	haihong	haihong	PROPN
fnp-4366	398	67	guo1	guo1	PROPN
fnp-4366	398	68	,	,	PUNCT
fnp-4366	398	69	priyanka	priyanka	PROPN
fnp-4366	398	70	tripathi1	tripathi1	PROPN
fnp-4366	398	71	,	,	PUNCT
fnp-4366	398	72	antonio	antonio	PROPN
fnp-4366	398	73	sechi3	sechi3	PROPN
fnp-4366	398	74	,	,	PUNCT
fnp-4366	398	75	alfred	alfred	PROPN
fnp-4366	398	76	yamoah1	yamoah1	PROPN
fnp-4366	398	77	,	,	PUNCT
fnp-4366	398	78	shelisa	shelisa	PROPN
fnp-4366	398	79	tey1	tey1	NOUN
fnp-4366	398	80	,	,	PUNCT
fnp-4366	398	81	michael	michael	PROPN
fnp-4366	398	82	schröder1	schröder1	PROPN
fnp-4366	398	83	,	,	PUNCT
fnp-4366	398	84	jürgen	jürgen	PROPN
fnp-4366	398	85	klingelhöfer4	klingelhöfer4	PROPN
fnp-4366	398	86	,	,	PUNCT
fnp-4366	398	87	joachim	joachim	PROPN
fnp-4366	398	88	weis1	weis1	PROPN
fnp-4366	398	89	,	,	PUNCT
fnp-4366	398	90	anand	anand	NOUN
fnp-4366	398	91	goswami1	goswami1	PROPN
fnp-4366	398	92	1	1	NUM
fnp-4366	398	93	uniklinik	uniklinik	NOUN
fnp-4366	398	94	rwth	rwth	NOUN
fnp-4366	398	95	aachen	aachen	PROPN
fnp-4366	398	96	,	,	PUNCT
fnp-4366	398	97	institut	institut	PROPN
fnp-4366	398	98	für	für	PROPN
fnp-4366	398	99	neuropathologie	neuropathologie	PROPN
fnp-4366	398	100	,	,	PUNCT
fnp-4366	398	101	aachen	aachen	PROPN
fnp-4366	398	102	,	,	PUNCT
fnp-4366	398	103	deutschland	deutschland	NOUN
fnp-4366	398	104	2	2	NUM
fnp-4366	398	105	uniklinik	uniklinik	NOUN
fnp-4366	398	106	köln	köln	NOUN
fnp-4366	398	107	,	,	PUNCT
fnp-4366	398	108	kinderklinik	kinderklinik	NOUN
fnp-4366	398	109	,	,	PUNCT
fnp-4366	398	110	köln	köln	NOUN
fnp-4366	398	111	,	,	PUNCT
fnp-4366	398	112	deutschland	deutschland	NOUN
fnp-4366	398	113	3	3	NUM
fnp-4366	398	114	uniklinik	uniklinik	NOUN
fnp-4366	398	115	rwth	rwth	NOUN
fnp-4366	398	116	aachen	aachen	PROPN
fnp-4366	398	117	,	,	PUNCT
fnp-4366	398	118	institut	institut	PROPN
fnp-4366	398	119	für	für	PROPN
fnp-4366	398	120	zellund	zellund	PROPN
fnp-4366	398	121	tumorbiologie	tumorbiologie	PROPN
fnp-4366	398	122	,	,	PUNCT
fnp-4366	398	123	aachen	aachen	PROPN
fnp-4366	398	124	,	,	PUNCT
fnp-4366	398	125	deutschland	deutschland	NOUN
fnp-4366	398	126	4	4	NUM
fnp-4366	398	127	klinikum	klinikum	NOUN
fnp-4366	398	128	chemnitz	chemnitz	PROPN
fnp-4366	398	129	,	,	PUNCT
fnp-4366	398	130	klinik	klinik	PROPN
fnp-4366	398	131	für	für	PROPN
fnp-4366	398	132	neurologie	neurologie	PROPN
fnp-4366	398	133	,	,	PUNCT
fnp-4366	398	134	chemnitz	chemnitz	PROPN
fnp-4366	398	135	,	,	PUNCT
fnp-4366	398	136	deutschland	deutschland	NOUN
fnp-4366	398	137	background	background	NOUN
fnp-4366	398	138	:	:	PUNCT
fnp-4366	398	139	atlastin-1	atlastin-1	PROPN
fnp-4366	398	140	(	(	PUNCT
fnp-4366	398	141	atl1	atl1	PROPN
fnp-4366	398	142	)	)	PUNCT
fnp-4366	398	143	functions	function	NOUN
fnp-4366	398	144	as	as	ADP
fnp-4366	398	145	a	a	DET
fnp-4366	398	146	gtpase	gtpase	NOUN
fnp-4366	398	147	and	and	CCONJ
fnp-4366	398	148	is	be	AUX
fnp-4366	398	149	crucial	crucial	ADJ
fnp-4366	398	150	for	for	ADP
fnp-4366	398	151	endoplasmic	endoplasmic	ADJ
fnp-4366	398	152	reticulum	reticulum	NOUN
fnp-4366	398	153	(	(	PUNCT
fnp-4366	398	154	er	er	INTJ
fnp-4366	398	155	)	)	PUNCT
fnp-4366	398	156	shaping	shaping	NOUN
fnp-4366	398	157	and	and	CCONJ
fnp-4366	398	158	er	er	INTJ
fnp-4366	398	159	-	-	PUNCT
fnp-4366	398	160	microtubule	microtubule	NOUN
fnp-4366	398	161	interactions	interaction	NOUN
fnp-4366	398	162	.	.	PUNCT
fnp-4366	399	1	mutations	mutation	NOUN
fnp-4366	399	2	in	in	ADP
fnp-4366	399	3	atl1	atl1	PROPN
fnp-4366	399	4	have	have	AUX
fnp-4366	399	5	been	be	AUX
fnp-4366	399	6	reported	report	VERB
fnp-4366	399	7	to	to	PART
fnp-4366	399	8	cause	cause	VERB
fnp-4366	399	9	hereditary	hereditary	ADJ
fnp-4366	399	10	sensory	sensory	ADJ
fnp-4366	399	11	and	and	CCONJ
fnp-4366	399	12	autonomic	autonomic	ADJ
fnp-4366	399	13	neuropathy	neuropathy	ADJ
fnp-4366	399	14	type	type	NOUN
fnp-4366	399	15	1d	1d	NUM
fnp-4366	399	16	(	(	PUNCT
fnp-4366	399	17	hsan1d	hsan1d	NOUN
fnp-4366	399	18	)	)	PUNCT
fnp-4366	399	19	as	as	ADV
fnp-4366	399	20	well	well	ADV
fnp-4366	399	21	as	as	ADP
fnp-4366	399	22	hereditary	hereditary	ADJ
fnp-4366	399	23	spastic	spastic	ADJ
fnp-4366	399	24	paraplegia	paraplegia	NOUN
fnp-4366	399	25	3a	3a	NUM
fnp-4366	399	26	(	(	PUNCT
fnp-4366	399	27	spg3a	spg3a	PROPN
fnp-4366	399	28	)	)	PUNCT
fnp-4366	399	29	.	.	PUNCT
fnp-4366	400	1	atl1	atl1	PROPN
fnp-4366	400	2	mutation	mutation	NOUN
fnp-4366	400	3	have	have	AUX
fnp-4366	400	4	been	be	AUX
fnp-4366	400	5	linked	link	VERB
fnp-4366	400	6	to	to	ADP
fnp-4366	400	7	abnormal	abnormal	ADJ
fnp-4366	400	8	er	er	INTJ
fnp-4366	400	9	morphology	morphology	NOUN
fnp-4366	400	10	;	;	PUNCT
fnp-4366	400	11	still	still	ADV
fnp-4366	400	12	the	the	DET
fnp-4366	400	13	molecular	molecular	ADJ
fnp-4366	400	14	pathomechanism	pathomechanism	NOUN
fnp-4366	400	15	of	of	ADP
fnp-4366	400	16	defective	defective	ADJ
fnp-4366	400	17	er	er	INTJ
fnp-4366	400	18	structures	structure	NOUN
fnp-4366	400	19	and	and	CCONJ
fnp-4366	400	20	their	their	PRON
fnp-4366	400	21	pathological	pathological	ADJ
fnp-4366	400	22	consequences	consequence	NOUN
fnp-4366	400	23	contributing	contribute	VERB
fnp-4366	400	24	to	to	ADP
fnp-4366	400	25	hsan1d	hsan1d	PROPN
fnp-4366	400	26	and	and	CCONJ
fnp-4366	400	27	spg3a	spg3a	PROPN
fnp-4366	400	28	have	have	AUX
fnp-4366	400	29	not	not	PART
fnp-4366	400	30	been	be	AUX
fnp-4366	400	31	investigated	investigate	VERB
fnp-4366	400	32	in	in	ADP
fnp-4366	400	33	detail	detail	NOUN
fnp-4366	400	34	so	so	ADV
fnp-4366	400	35	far	far	ADV
fnp-4366	400	36	.	.	PUNCT
fnp-4366	401	1	question	question	NOUN
fnp-4366	401	2	:	:	PUNCT
fnp-4366	401	3	we	we	PRON
fnp-4366	401	4	asked	ask	VERB
fnp-4366	401	5	if	if	SCONJ
fnp-4366	401	6	/	/	SYM
fnp-4366	401	7	how	how	SCONJ
fnp-4366	401	8	atl1	atl1	PROPN
fnp-4366	401	9	participates	participate	VERB
fnp-4366	401	10	in	in	ADP
fnp-4366	401	11	autophagy	autophagy	ADJ
fnp-4366	401	12	process	process	NOUN
fnp-4366	401	13	.	.	PUNCT
fnp-4366	402	1	methods	method	NOUN
fnp-4366	402	2	:	:	PUNCT
fnp-4366	402	3	we	we	PRON
fnp-4366	402	4	used	use	VERB
fnp-4366	402	5	biochemical	biochemical	ADJ
fnp-4366	402	6	and	and	CCONJ
fnp-4366	402	7	immunocytochemistry	immunocytochemistry	NOUN
fnp-4366	402	8	approaches	approach	NOUN
fnp-4366	402	9	followed	follow	VERB
fnp-4366	402	10	by	by	ADP
fnp-4366	402	11	live	live	ADJ
fnp-4366	402	12	cell	cell	NOUN
fnp-4366	402	13	imaging	imaging	NOUN
fnp-4366	402	14	in	in	ADP
fnp-4366	402	15	cell	cell	NOUN
fnp-4366	402	16	culture	culture	NOUN
fnp-4366	402	17	models	model	NOUN
fnp-4366	402	18	overexpressing	overexpresse	VERB
fnp-4366	402	19	normal	normal	ADJ
fnp-4366	402	20	and	and	CCONJ
fnp-4366	402	21	mutant	mutant	ADJ
fnp-4366	402	22	atl1	atl1	ADJ
fnp-4366	402	23	proteins	protein	NOUN
fnp-4366	402	24	.	.	PUNCT
fnp-4366	403	1	we	we	PRON
fnp-4366	403	2	corroborated	corroborate	VERB
fnp-4366	403	3	our	our	PRON
fnp-4366	403	4	findings	finding	NOUN
fnp-4366	403	5	with	with	ADP
fnp-4366	403	6	comparative	comparative	ADJ
fnp-4366	403	7	ultrastructural	ultrastructural	ADJ
fnp-4366	403	8	analysis	analysis	NOUN
fnp-4366	403	9	on	on	ADP
fnp-4366	403	10	cell	cell	NOUN
fnp-4366	403	11	culture	culture	NOUN
fnp-4366	403	12	models	model	NOUN
fnp-4366	403	13	and	and	CCONJ
fnp-4366	403	14	on	on	ADP
fnp-4366	403	15	biopsy	biopsy	NOUN
fnp-4366	403	16	samples	sample	NOUN
fnp-4366	403	17	.	.	PUNCT
fnp-4366	404	1	results	result	NOUN
fnp-4366	404	2	:	:	PUNCT
fnp-4366	404	3	we	we	PRON
fnp-4366	404	4	observed	observe	VERB
fnp-4366	404	5	that	that	SCONJ
fnp-4366	404	6	over	over	ADP
fnp-4366	404	7	-	-	PUNCT
fnp-4366	404	8	expression	expression	NOUN
fnp-4366	404	9	of	of	ADP
fnp-4366	404	10	mutant	mutant	ADJ
fnp-4366	404	11	atl1	atl1	PROPN
fnp-4366	404	12	(	(	PUNCT
fnp-4366	404	13	gly66gln	gly66gln	ADJ
fnp-4366	404	14	)	)	PUNCT
fnp-4366	404	15	forms	form	VERB
fnp-4366	404	16	protease	protease	NOUN
fnp-4366	404	17	resistant	resistant	ADJ
fnp-4366	404	18	large	large	ADJ
fnp-4366	404	19	,	,	PUNCT
fnp-4366	404	20	globular	globular	ADJ
fnp-4366	404	21	er	er	INTJ
fnp-4366	404	22	associated	associate	VERB
fnp-4366	404	23	aggregates	aggregate	NOUN
fnp-4366	404	24	in	in	ADP
fnp-4366	404	25	cell	cell	NOUN
fnp-4366	404	26	culture	culture	NOUN
fnp-4366	404	27	models	model	NOUN
fnp-4366	404	28	,	,	PUNCT
fnp-4366	404	29	which	which	PRON
fnp-4366	404	30	further	far	ADV
fnp-4366	404	31	leads	lead	VERB
fnp-4366	404	32	to	to	ADP
fnp-4366	404	33	er	er	INTJ
fnp-4366	404	34	stress	stress	NOUN
fnp-4366	404	35	and	and	CCONJ
fnp-4366	404	36	structural	structural	ADJ
fnp-4366	404	37	abnormalities	abnormality	NOUN
fnp-4366	404	38	of	of	ADP
fnp-4366	404	39	er	er	INTJ
fnp-4366	404	40	and	and	CCONJ
fnp-4366	404	41	associated	associated	ADJ
fnp-4366	404	42	compartments	compartment	NOUN
fnp-4366	404	43	.	.	PUNCT
fnp-4366	405	1	interestingly	interestingly	ADV
fnp-4366	405	2	while	while	SCONJ
fnp-4366	405	3	endogenous	endogenous	ADJ
fnp-4366	405	4	atl1	atl1	ADJ
fnp-4366	405	5	protein	protein	NOUN
fnp-4366	405	6	is	be	AUX
fnp-4366	405	7	degraded	degrade	VERB
fnp-4366	405	8	by	by	ADP
fnp-4366	405	9	ubiquitin	ubiquitin	ADJ
fnp-4366	405	10	proteasome	proteasome	NOUN
fnp-4366	405	11	system	system	NOUN
fnp-4366	405	12	(	(	PUNCT
fnp-4366	405	13	ups	up	NOUN
fnp-4366	405	14	)	)	PUNCT
fnp-4366	405	15	,	,	PUNCT
fnp-4366	405	16	mutant	mutant	ADJ
fnp-4366	405	17	atl1	atl1	PROPN
fnp-4366	405	18	impairs	impair	VERB
fnp-4366	405	19	ups	up	NOUN
fnp-4366	405	20	,	,	PUNCT
fnp-4366	405	21	induces	induce	VERB
fnp-4366	405	22	proteotoxicity	proteotoxicity	NOUN
fnp-4366	405	23	and	and	CCONJ
fnp-4366	405	24	cell	cell	NOUN
fnp-4366	405	25	death	death	NOUN
fnp-4366	405	26	.	.	PUNCT
fnp-4366	406	1	autophagy	autophagy	NOUN
fnp-4366	406	2	,	,	PUNCT
fnp-4366	406	3	which	which	PRON
fnp-4366	406	4	activates	activate	VERB
fnp-4366	406	5	as	as	ADP
fnp-4366	406	6	a	a	DET
fnp-4366	406	7	compensatory	compensatory	ADJ
fnp-4366	406	8	mechanism	mechanism	NOUN
fnp-4366	406	9	,	,	PUNCT
fnp-4366	406	10	also	also	ADV
fnp-4366	406	11	compromises	compromise	VERB
fnp-4366	406	12	at	at	ADP
fnp-4366	406	13	multiple	multiple	ADJ
fnp-4366	406	14	steps	step	NOUN
fnp-4366	406	15	,	,	PUNCT
fnp-4366	406	16	probably	probably	ADV
fnp-4366	406	17	due	due	ADJ
fnp-4366	406	18	to	to	ADP
fnp-4366	406	19	deformities	deformity	NOUN
fnp-4366	406	20	of	of	ADP
fnp-4366	406	21	er	er	INTJ
fnp-4366	406	22	and	and	CCONJ
fnp-4366	406	23	persistent	persistent	ADJ
fnp-4366	406	24	proteotoxic	proteotoxic	ADJ
fnp-4366	406	25	stress	stress	NOUN
fnp-4366	406	26	.	.	PUNCT
fnp-4366	407	1	extensive	extensive	ADJ
fnp-4366	407	2	workup	workup	NOUN
fnp-4366	407	3	of	of	ADP
fnp-4366	407	4	skin	skin	NOUN
fnp-4366	407	5	,	,	PUNCT
fnp-4366	407	6	sural	sural	ADJ
fnp-4366	407	7	nerve	nerve	NOUN
fnp-4366	407	8	and	and	CCONJ
fnp-4366	407	9	muscle	muscle	NOUN
fnp-4366	407	10	biopsy	biopsy	NOUN
fnp-4366	407	11	material	material	NOUN
fnp-4366	407	12	of	of	ADP
fnp-4366	407	13	a	a	DET
fnp-4366	407	14	rare	rare	ADJ
fnp-4366	407	15	gly66gln	gly66gln	ADJ
fnp-4366	407	16	hsan1	hsan1	NOUN
fnp-4366	407	17	patient	patient	NOUN
fnp-4366	407	18	revealed	reveal	VERB
fnp-4366	407	19	prominent	prominent	ADJ
fnp-4366	407	20	loss	loss	NOUN
fnp-4366	407	21	of	of	ADP
fnp-4366	407	22	myelinated	myelinated	ADJ
fnp-4366	407	23	and	and	CCONJ
fnp-4366	407	24	unmyelinated	unmyelinated	ADJ
fnp-4366	407	25	sural	sural	ADJ
fnp-4366	407	26	nerve	nerve	NOUN
fnp-4366	407	27	fibres	fibre	NOUN
fnp-4366	407	28	,	,	PUNCT
fnp-4366	407	29	but	but	CCONJ
fnp-4366	407	30	only	only	ADV
fnp-4366	407	31	minor	minor	ADJ
fnp-4366	407	32	neurogenic	neurogenic	ADJ
fnp-4366	407	33	muscular	muscular	ADJ
fnp-4366	407	34	atrophy	atrophy	NOUN
fnp-4366	407	35	.	.	PUNCT
fnp-4366	408	1	ultrastructural	ultrastructural	ADJ
fnp-4366	408	2	analysis	analysis	NOUN
fnp-4366	408	3	on	on	ADP
fnp-4366	408	4	this	this	DET
fnp-4366	408	5	biopsy	biopsy	NOUN
fnp-4366	408	6	revealed	reveal	VERB
fnp-4366	408	7	signs	sign	NOUN
fnp-4366	408	8	of	of	ADP
fnp-4366	408	9	altered	altered	ADJ
fnp-4366	408	10	autophagy	autophagy	NOUN
fnp-4366	408	11	in	in	ADP
fnp-4366	408	12	axons	axon	NOUN
fnp-4366	408	13	as	as	ADV
fnp-4366	408	14	well	well	ADV
fnp-4366	408	15	as	as	ADP
fnp-4366	408	16	prominent	prominent	ADJ
fnp-4366	408	17	alterations	alteration	NOUN
fnp-4366	408	18	of	of	ADP
fnp-4366	408	19	schwann	schwann	PROPN
fnp-4366	408	20	cell	cell	NOUN
fnp-4366	408	21	nuclei	nucleus	NOUN
fnp-4366	408	22	/	/	SYM
fnp-4366	408	23	nuclear	nuclear	ADJ
fnp-4366	408	24	envelope	envelope	NOUN
fnp-4366	408	25	.	.	PUNCT
fnp-4366	409	1	in	in	ADP
fnp-4366	409	2	line	line	NOUN
fnp-4366	409	3	with	with	ADP
fnp-4366	409	4	this	this	PRON
fnp-4366	409	5	,	,	PUNCT
fnp-4366	409	6	hsan1	hsan1	NOUN
fnp-4366	409	7	patient	patient	NOUN
fnp-4366	409	8	's	's	PART
fnp-4366	409	9	fibroblasts	fibroblast	NOUN
fnp-4366	409	10	showed	show	VERB
fnp-4366	409	11	similar	similar	ADJ
fnp-4366	409	12	defects	defect	NOUN
fnp-4366	409	13	.	.	PUNCT
fnp-4366	410	1	conclusions	conclusion	NOUN
fnp-4366	410	2	:	:	PUNCT
fnp-4366	410	3	overall	overall	ADV
fnp-4366	410	4	,	,	PUNCT
fnp-4366	410	5	our	our	PRON
fnp-4366	410	6	results	result	NOUN
fnp-4366	410	7	support	support	VERB
fnp-4366	410	8	the	the	DET
fnp-4366	410	9	notion	notion	NOUN
fnp-4366	410	10	that	that	SCONJ
fnp-4366	410	11	neurodegeneration	neurodegeneration	NOUN
fnp-4366	410	12	in	in	ADP
fnp-4366	410	13	hsan1	hsan1	NOUN
fnp-4366	410	14	due	due	ADP
fnp-4366	410	15	to	to	ADP
fnp-4366	410	16	atl1	atl1	ADJ
fnp-4366	410	17	mutation	mutation	NOUN
fnp-4366	410	18	is	be	AUX
fnp-4366	410	19	closely	closely	ADV
fnp-4366	410	20	linked	link	VERB
fnp-4366	410	21	with	with	ADP
fnp-4366	410	22	the	the	DET
fnp-4366	410	23	deformed	deform	VERB
fnp-4366	410	24	er	er	INTJ
fnp-4366	410	25	and	and	CCONJ
fnp-4366	410	26	associated	associated	ADJ
fnp-4366	410	27	functions	function	NOUN
fnp-4366	410	28	including	include	VERB
fnp-4366	410	29	autophagy	autophagy	NOUN
fnp-4366	410	30	.	.	PUNCT
fnp-4366	411	1	neurons	neuron	NOUN
fnp-4366	411	2	and	and	CCONJ
fnp-4366	411	3	distal	distal	ADJ
fnp-4366	411	4	axons	axon	NOUN
fnp-4366	411	5	are	be	AUX
fnp-4366	411	6	particularly	particularly	ADV
fnp-4366	411	7	vulnerable	vulnerable	ADJ
fnp-4366	411	8	to	to	ADP
fnp-4366	411	9	such	such	ADJ
fnp-4366	411	10	pathomechanism	pathomechanism	NOUN
fnp-4366	411	11	,	,	PUNCT
fnp-4366	411	12	thus	thus	ADV
fnp-4366	411	13	explaining	explain	VERB
fnp-4366	411	14	the	the	DET
fnp-4366	411	15	degenerative	degenerative	ADJ
fnp-4366	411	16	phenotype	phenotype	NOUN
fnp-4366	411	17	in	in	ADP
fnp-4366	411	18	hsan	hsan	NOUN
fnp-4366	411	19	1	1	NUM
fnp-4366	411	20	and	and	CCONJ
fnp-4366	411	21	related	related	ADJ
fnp-4366	411	22	diseases	disease	NOUN
fnp-4366	411	23	.	.	PUNCT
fnp-4366	411	24	  	  	SPACE
fnp-4366	412	1	3.07	3.07	NUM
fnp-4366	412	2	free	free	ADJ
fnp-4366	412	3	neuropathol	neuropathol	NOUN
fnp-4366	412	4	3:20:42	3:20:42	NUM
fnp-4366	412	5	single	single	ADJ
fnp-4366	412	6	-	-	PUNCT
fnp-4366	412	7	nucleus	nucleus	NOUN
fnp-4366	412	8	chromatin	chromatin	NOUN
fnp-4366	412	9	accessibility	accessibility	NOUN
fnp-4366	412	10	profiling	profiling	NOUN
fnp-4366	412	11	in	in	ADP
fnp-4366	412	12	four	four	NUM
fnp-4366	412	13	-	-	PUNCT
fnp-4366	412	14	repeat	repeat	NOUN
fnp-4366	412	15	tauopathies	tauopathie	NOUN
fnp-4366	412	16	viktoria	viktoria	PROPN
fnp-4366	412	17	ruf1	ruf1	PROPN
fnp-4366	412	18	,	,	PUNCT
fnp-4366	412	19	nils	nils	PROPN
fnp-4366	412	20	briel1,2	briel1,2	PROPN
fnp-4366	412	21	,	,	PUNCT
fnp-4366	412	22	sigrun	sigrun	NOUN
fnp-4366	412	23	roeber1	roeber1	PROPN
fnp-4366	412	24	,	,	PUNCT
fnp-4366	412	25	janina	janina	PROPN
fnp-4366	412	26	mielke1	mielke1	PROPN
fnp-4366	412	27	,	,	PUNCT
fnp-4366	412	28	mario	mario	PROPN
fnp-4366	412	29	m	m	PROPN
fnp-4366	412	30	dorostkar1	dorostkar1	PROPN
fnp-4366	412	31	,	,	PUNCT
fnp-4366	412	32	otto	otto	PROPN
fnp-4366	412	33	windl1,2	windl1,2	PROPN
fnp-4366	412	34	,	,	PUNCT
fnp-4366	412	35	thomas	thomas	PROPN
fnp-4366	412	36	arzberger1,2,3	arzberger1,2,3	PROPN
fnp-4366	412	37	,	,	PUNCT
fnp-4366	412	38	felix	felix	PROPN
fnp-4366	412	39	l.	l.	PROPN
fnp-4366	412	40	strübing1,2	strübing1,2	PROPN
fnp-4366	412	41	,	,	PUNCT
fnp-4366	412	42	jochen	jochen	PROPN
fnp-4366	412	43	herms1,2,4	herms1,2,4	PROPN
fnp-4366	412	44	1	1	NUM
fnp-4366	412	45	zentrum	zentrum	PROPN
fnp-4366	412	46	für	für	PROPN
fnp-4366	412	47	neuropathologie	neuropathologie	PROPN
fnp-4366	412	48	und	und	PROPN
fnp-4366	412	49	prionforschung	prionforschung	PROPN
fnp-4366	412	50	,	,	PUNCT
fnp-4366	412	51	münchen	münchen	NOUN
fnp-4366	412	52	,	,	PUNCT
fnp-4366	412	53	deutschland	deutschland	NOUN
fnp-4366	412	54	2	2	NUM
fnp-4366	412	55	deutsches	deutsche	NOUN
fnp-4366	412	56	zentrum	zentrum	PROPN
fnp-4366	412	57	für	für	PROPN
fnp-4366	412	58	neurodegenerative	neurodegenerative	ADJ
fnp-4366	412	59	erkrankungen	erkrankungen	PROPN
fnp-4366	412	60	,	,	PUNCT
fnp-4366	412	61	münchen	münchen	NOUN
fnp-4366	412	62	,	,	PUNCT
fnp-4366	412	63	deutschland	deutschland	NOUN
fnp-4366	412	64	3	3	NUM
fnp-4366	412	65	klinik	klinik	PROPN
fnp-4366	412	66	für	für	PROPN
fnp-4366	412	67	psychiatrie	psychiatrie	PROPN
fnp-4366	412	68	und	und	PROPN
fnp-4366	412	69	psychotherapie	psychotherapie	NOUN
fnp-4366	412	70	,	,	PUNCT
fnp-4366	412	71	münchen	münchen	NOUN
fnp-4366	412	72	,	,	PUNCT
fnp-4366	412	73	deutschland	deutschland	NOUN
fnp-4366	412	74	4	4	NUM
fnp-4366	412	75	munich	munich	PROPN
fnp-4366	412	76	cluster	cluster	NOUN
fnp-4366	412	77	of	of	ADP
fnp-4366	412	78	systems	system	NOUN
fnp-4366	412	79	neurology	neurology	NOUN
fnp-4366	412	80	(	(	PUNCT
fnp-4366	412	81	synergy	synergy	NOUN
fnp-4366	412	82	)	)	PUNCT
fnp-4366	412	83	,	,	PUNCT
fnp-4366	412	84	münchen	münchen	NOUN
fnp-4366	412	85	,	,	PUNCT
fnp-4366	412	86	deutschland	deutschland	NOUN
fnp-4366	412	87	background	background	NOUN
fnp-4366	412	88	:	:	PUNCT
fnp-4366	412	89	progressive	progressive	ADJ
fnp-4366	412	90	supranuclear	supranuclear	ADJ
fnp-4366	412	91	palsy	palsy	ADJ
fnp-4366	412	92	(	(	PUNCT
fnp-4366	412	93	psp	psp	NOUN
fnp-4366	412	94	)	)	PUNCT
fnp-4366	412	95	and	and	CCONJ
fnp-4366	412	96	corticobasal	corticobasal	NOUN
fnp-4366	412	97	degeneration	degeneration	NOUN
fnp-4366	412	98	(	(	PUNCT
fnp-4366	412	99	cbd	cbd	NOUN
fnp-4366	412	100	)	)	PUNCT
fnp-4366	412	101	are	be	AUX
fnp-4366	412	102	sporadic	sporadic	ADJ
fnp-4366	412	103	neurodegenerative	neurodegenerative	ADJ
fnp-4366	412	104	diseases	disease	NOUN
fnp-4366	412	105	characterized	characterize	VERB
fnp-4366	412	106	by	by	ADP
fnp-4366	412	107	aggregates	aggregate	NOUN
fnp-4366	412	108	of	of	ADP
fnp-4366	412	109	hyperphosphorylated	hyperphosphorylated	ADJ
fnp-4366	412	110	four	four	NUM
fnp-4366	412	111	-	-	PUNCT
fnp-4366	412	112	repeat	repeat	NOUN
fnp-4366	412	113	tau	tau	PROPN
fnp-4366	412	114	(	(	PUNCT
fnp-4366	412	115	4r	4r	PROPN
fnp-4366	412	116	-	-	PUNCT
fnp-4366	412	117	tau	tau	NOUN
fnp-4366	412	118	)	)	PUNCT
fnp-4366	412	119	in	in	ADP
fnp-4366	412	120	neurons	neuron	NOUN
fnp-4366	412	121	,	,	PUNCT
fnp-4366	412	122	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	412	123	and	and	CCONJ
fnp-4366	412	124	astrocytes	astrocyte	NOUN
fnp-4366	412	125	,	,	PUNCT
fnp-4366	412	126	where	where	SCONJ
fnp-4366	412	127	tufted	tufte	VERB
fnp-4366	412	128	astrocytes	astrocyte	NOUN
fnp-4366	412	129	(	(	PUNCT
fnp-4366	412	130	ta	ta	NOUN
fnp-4366	412	131	)	)	PUNCT
fnp-4366	412	132	are	be	AUX
fnp-4366	412	133	a	a	DET
fnp-4366	412	134	typical	typical	ADJ
fnp-4366	412	135	hallmark	hallmark	NOUN
fnp-4366	412	136	of	of	ADP
fnp-4366	412	137	psp	psp	NOUN
fnp-4366	412	138	,	,	PUNCT
fnp-4366	412	139	whereas	whereas	SCONJ
fnp-4366	412	140	astrocytic	astrocytic	ADJ
fnp-4366	412	141	plaques	plaque	NOUN
fnp-4366	412	142	(	(	PUNCT
fnp-4366	412	143	ap	ap	X
fnp-4366	412	144	)	)	PUNCT
fnp-4366	412	145	are	be	AUX
fnp-4366	412	146	pathognomonic	pathognomonic	ADJ
fnp-4366	412	147	for	for	ADP
fnp-4366	412	148	cbd	cbd	NOUN
fnp-4366	412	149	.	.	PUNCT
fnp-4366	413	1	the	the	DET
fnp-4366	413	2	molecular	molecular	ADJ
fnp-4366	413	3	mechanisms	mechanism	NOUN
fnp-4366	413	4	underlying	underlie	VERB
fnp-4366	413	5	tau	tau	PROPN
fnp-4366	413	6	aggregation	aggregation	NOUN
fnp-4366	413	7	and	and	CCONJ
fnp-4366	413	8	neurodegeneration	neurodegeneration	NOUN
fnp-4366	413	9	are	be	AUX
fnp-4366	413	10	largely	largely	ADV
fnp-4366	413	11	unclear	unclear	ADJ
fnp-4366	413	12	.	.	PUNCT
fnp-4366	414	1	aims	aim	NOUN
fnp-4366	414	2	and	and	CCONJ
fnp-4366	414	3	questions	question	NOUN
fnp-4366	414	4	:	:	PUNCT
fnp-4366	414	5	to	to	PART
fnp-4366	414	6	characterize	characterize	VERB
fnp-4366	414	7	chromatin	chromatin	NOUN
fnp-4366	414	8	accessibility	accessibility	NOUN
fnp-4366	414	9	profiles	profile	NOUN
fnp-4366	414	10	of	of	ADP
fnp-4366	414	11	psp	psp	NOUN
fnp-4366	414	12	and	and	CCONJ
fnp-4366	414	13	cbd	cbd	NOUN
fnp-4366	414	14	using	use	VERB
fnp-4366	414	15	atac	atac	NOUN
fnp-4366	414	16	-	-	PUNCT
fnp-4366	414	17	seq	seq	NOUN
fnp-4366	414	18	(	(	PUNCT
fnp-4366	414	19	assay	assay	VERB
fnp-4366	414	20	for	for	ADP
fnp-4366	414	21	transposase	transposase	NOUN
fnp-4366	414	22	-	-	PUNCT
fnp-4366	414	23	accessible	accessible	ADJ
fnp-4366	414	24	chromatin	chromatin	NOUN
fnp-4366	414	25	using	use	VERB
fnp-4366	414	26	sequencing	sequencing	NOUN
fnp-4366	414	27	)	)	PUNCT
fnp-4366	414	28	to	to	PART
fnp-4366	414	29	contribute	contribute	VERB
fnp-4366	414	30	to	to	ADP
fnp-4366	414	31	a	a	DET
fnp-4366	414	32	better	well	ADJ
fnp-4366	414	33	understanding	understanding	NOUN
fnp-4366	414	34	of	of	ADP
fnp-4366	414	35	the	the	DET
fnp-4366	414	36	underlying	underlie	VERB
fnp-4366	414	37	pathomechanisms	pathomechanism	NOUN
fnp-4366	414	38	of	of	ADP
fnp-4366	414	39	psp	psp	NOUN
fnp-4366	414	40	and	and	CCONJ
fnp-4366	414	41	cbd	cbd	PROPN
fnp-4366	414	42	.	.	PUNCT
fnp-4366	415	1	methods	method	NOUN
fnp-4366	415	2	:	:	PUNCT
fnp-4366	415	3	atac	atac	NOUN
fnp-4366	415	4	-	-	PUNCT
fnp-4366	415	5	seq	seq	NOUN
fnp-4366	415	6	was	be	AUX
fnp-4366	415	7	performed	perform	VERB
fnp-4366	415	8	on	on	ADP
fnp-4366	415	9	45,000	45,000	NUM
fnp-4366	415	10	isolated	isolate	VERB
fnp-4366	415	11	single	single	ADJ
fnp-4366	415	12	nuclei	nucleus	NOUN
fnp-4366	415	13	from	from	ADP
fnp-4366	415	14	the	the	DET
fnp-4366	415	15	frontal	frontal	ADJ
fnp-4366	415	16	cortex	cortex	NOUN
fnp-4366	415	17	of	of	ADP
fnp-4366	415	18	4	4	NUM
fnp-4366	415	19	psp	psp	NOUN
fnp-4366	415	20	and	and	CCONJ
fnp-4366	415	21	4	4	NUM
fnp-4366	415	22	cbd	cbd	NOUN
fnp-4366	415	23	patients	patient	NOUN
fnp-4366	415	24	and	and	CCONJ
fnp-4366	415	25	5	5	NUM
fnp-4366	415	26	healthy	healthy	ADJ
fnp-4366	415	27	controls	control	NOUN
fnp-4366	415	28	.	.	PUNCT
fnp-4366	416	1	after	after	ADP
fnp-4366	416	2	preprocessing	preprocesse	VERB
fnp-4366	416	3	and	and	CCONJ
fnp-4366	416	4	quality	quality	NOUN
fnp-4366	416	5	control	control	NOUN
fnp-4366	416	6	,	,	PUNCT
fnp-4366	416	7	gene	gene	NOUN
fnp-4366	416	8	accessibility	accessibility	NOUN
fnp-4366	416	9	(	(	PUNCT
fnp-4366	416	10	ga	ga	NOUN
fnp-4366	416	11	)	)	PUNCT
fnp-4366	416	12	,	,	PUNCT
fnp-4366	416	13	gene	gene	NOUN
fnp-4366	416	14	ontology	ontology	NOUN
fnp-4366	416	15	(	(	PUNCT
fnp-4366	416	16	go	go	VERB
fnp-4366	416	17	)	)	PUNCT
fnp-4366	416	18	and	and	CCONJ
fnp-4366	416	19	transcription	transcription	NOUN
fnp-4366	416	20	factor	factor	NOUN
fnp-4366	416	21	motif	motif	NOUN
fnp-4366	416	22	enrichment	enrichment	NOUN
fnp-4366	416	23	(	(	PUNCT
fnp-4366	416	24	tfme	tfme	NOUN
fnp-4366	416	25	)	)	PUNCT
fnp-4366	416	26	analysis	analysis	NOUN
fnp-4366	416	27	were	be	AUX
fnp-4366	416	28	conducted	conduct	VERB
fnp-4366	416	29	using	use	VERB
fnp-4366	416	30	snapatac	snapatac	NOUN
fnp-4366	416	31	.	.	PUNCT
fnp-4366	417	1	gchromvar	gchromvar	PROPN
fnp-4366	417	2	was	be	AUX
fnp-4366	417	3	applied	apply	VERB
fnp-4366	417	4	to	to	PART
fnp-4366	417	5	map	map	VERB
fnp-4366	417	6	genetic	genetic	ADJ
fnp-4366	417	7	risk	risk	NOUN
fnp-4366	417	8	variants	variant	NOUN
fnp-4366	417	9	to	to	ADP
fnp-4366	417	10	peaks	peak	NOUN
fnp-4366	417	11	and	and	CCONJ
fnp-4366	417	12	cicero	cicero	PROPN
fnp-4366	417	13	/	/	SYM
fnp-4366	417	14	tradeseq	tradeseq	NOUN
fnp-4366	417	15	was	be	AUX
fnp-4366	417	16	used	use	VERB
fnp-4366	417	17	for	for	ADP
fnp-4366	417	18	pseudotime	pseudotime	ADJ
fnp-4366	417	19	analysis	analysis	NOUN
fnp-4366	417	20	and	and	CCONJ
fnp-4366	417	21	repeated	repeat	VERB
fnp-4366	417	22	tfme	tfme	NOUN
fnp-4366	417	23	analysis	analysis	NOUN
fnp-4366	417	24	.	.	PUNCT
fnp-4366	418	1	results	result	NOUN
fnp-4366	418	2	:	:	PUNCT
fnp-4366	418	3	we	we	PRON
fnp-4366	418	4	found	find	VERB
fnp-4366	418	5	that	that	SCONJ
fnp-4366	418	6	ga	ga	PROPN
fnp-4366	418	7	of	of	ADP
fnp-4366	418	8	tauopathy	tauopathy	ADJ
fnp-4366	418	9	-	-	PUNCT
fnp-4366	418	10	associated	associate	VERB
fnp-4366	418	11	genes	gene	NOUN
fnp-4366	418	12	was	be	AUX
fnp-4366	418	13	substantially	substantially	ADV
fnp-4366	418	14	altered	alter	VERB
fnp-4366	418	15	in	in	ADP
fnp-4366	418	16	the	the	DET
fnp-4366	418	17	brains	brain	NOUN
fnp-4366	418	18	of	of	ADP
fnp-4366	418	19	psp	psp	NOUN
fnp-4366	418	20	and	and	CCONJ
fnp-4366	418	21	cbd	cbd	NOUN
fnp-4366	418	22	patients	patient	NOUN
fnp-4366	418	23	and	and	CCONJ
fnp-4366	418	24	could	could	AUX
fnp-4366	418	25	demonstrate	demonstrate	VERB
fnp-4366	418	26	that	that	SCONJ
fnp-4366	418	27	pspand	pspand	PROPN
fnp-4366	418	28	ftd	ftd	PROPN
fnp-4366	418	29	-	-	PUNCT
fnp-4366	418	30	associated	associate	VERB
fnp-4366	418	31	genetic	genetic	ADJ
fnp-4366	418	32	risk	risk	NOUN
fnp-4366	418	33	variants	variant	NOUN
fnp-4366	418	34	are	be	AUX
fnp-4366	418	35	particularly	particularly	ADV
fnp-4366	418	36	linked	link	VERB
fnp-4366	418	37	to	to	ADP
fnp-4366	418	38	astrocytic	astrocytic	ADJ
fnp-4366	418	39	chromatin	chromatin	NOUN
fnp-4366	418	40	accessibility	accessibility	NOUN
fnp-4366	418	41	profiles	profile	NOUN
fnp-4366	418	42	.	.	PUNCT
fnp-4366	419	1	go	go	VERB
fnp-4366	419	2	enrichment	enrichment	NOUN
fnp-4366	419	3	analysis	analysis	NOUN
fnp-4366	419	4	of	of	ADP
fnp-4366	419	5	significantly	significantly	ADV
fnp-4366	419	6	different	different	ADJ
fnp-4366	419	7	transcription	transcription	NOUN
fnp-4366	419	8	factor	factor	NOUN
fnp-4366	419	9	motifs	motifs	NOUN
fnp-4366	419	10	(	(	PUNCT
fnp-4366	419	11	tfm	tfm	NOUN
fnp-4366	419	12	)	)	PUNCT
fnp-4366	419	13	in	in	ADP
fnp-4366	419	14	astrocytes	astrocyte	NOUN
fnp-4366	419	15	identified	identify	VERB
fnp-4366	419	16	numerous	numerous	ADJ
fnp-4366	419	17	motifs	motif	NOUN
fnp-4366	419	18	belonging	belong	VERB
fnp-4366	419	19	to	to	ADP
fnp-4366	419	20	the	the	DET
fnp-4366	419	21	immediate	immediate	ADJ
fnp-4366	419	22	early	early	ADJ
fnp-4366	419	23	response	response	NOUN
fnp-4366	419	24	(	(	PUNCT
fnp-4366	419	25	ier	ier	X
fnp-4366	419	26	;	;	PUNCT
fnp-4366	419	27	e.g.	e.g.	ADV
fnp-4366	419	28	fos	fos	NOUN
fnp-4366	419	29	and	and	CCONJ
fnp-4366	419	30	jun	jun	PROPN
fnp-4366	419	31	family	family	NOUN
fnp-4366	419	32	)	)	PUNCT
fnp-4366	419	33	or	or	CCONJ
fnp-4366	419	34	intracellular	intracellular	ADJ
fnp-4366	419	35	homeostasis	homeostasis	NOUN
fnp-4366	419	36	and	and	CCONJ
fnp-4366	419	37	protein	protein	NOUN
fnp-4366	419	38	degradation	degradation	NOUN
fnp-4366	419	39	(	(	PUNCT
fnp-4366	419	40	e.g.	e.g.	ADV
fnp-4366	419	41	maf	maf	NOUN
fnp-4366	419	42	family	family	NOUN
fnp-4366	419	43	and	and	CCONJ
fnp-4366	419	44	nfe2	nfe2	PROPN
fnp-4366	419	45	)	)	PUNCT
fnp-4366	419	46	.	.	PUNCT
fnp-4366	420	1	moreover	moreover	ADV
fnp-4366	420	2	,	,	PUNCT
fnp-4366	420	3	pathway	pathway	NOUN
fnp-4366	420	4	analysis	analysis	NOUN
fnp-4366	420	5	highlighted	highlight	VERB
fnp-4366	420	6	immunological	immunological	ADJ
fnp-4366	420	7	terms	term	NOUN
fnp-4366	420	8	related	relate	VERB
fnp-4366	420	9	to	to	ADP
fnp-4366	420	10	both	both	CCONJ
fnp-4366	420	11	innate	innate	ADJ
fnp-4366	420	12	and	and	CCONJ
fnp-4366	420	13	acquired	acquire	VERB
fnp-4366	420	14	immunity	immunity	NOUN
fnp-4366	420	15	.	.	PUNCT
fnp-4366	421	1	pseudotime	pseudotime	ADJ
fnp-4366	421	2	analysis	analysis	NOUN
fnp-4366	421	3	of	of	ADP
fnp-4366	421	4	transcription	transcription	NOUN
fnp-4366	421	5	factor	factor	NOUN
fnp-4366	421	6	motif	motif	NOUN
fnp-4366	421	7	enrichment	enrichment	NOUN
fnp-4366	421	8	(	(	PUNCT
fnp-4366	421	9	tfme	tfme	NOUN
fnp-4366	421	10	)	)	PUNCT
fnp-4366	421	11	revealed	reveal	VERB
fnp-4366	421	12	for	for	ADP
fnp-4366	421	13	cbd	cbd	NOUN
fnp-4366	421	14	a	a	DET
fnp-4366	421	15	trajectory	trajectory	NOUN
fnp-4366	421	16	terminating	terminate	VERB
fnp-4366	421	17	in	in	ADP
fnp-4366	421	18	a	a	DET
fnp-4366	421	19	population	population	NOUN
fnp-4366	421	20	of	of	ADP
fnp-4366	421	21	cbd	cbd	NOUN
fnp-4366	421	22	-	-	PUNCT
fnp-4366	421	23	derived	derive	VERB
fnp-4366	421	24	astrocytes	astrocyte	NOUN
fnp-4366	421	25	,	,	PUNCT
fnp-4366	421	26	whereas	whereas	SCONJ
fnp-4366	421	27	for	for	ADP
fnp-4366	421	28	psp	psp	NOUN
fnp-4366	421	29	no	no	DET
fnp-4366	421	30	such	such	ADJ
fnp-4366	421	31	disease	disease	NOUN
fnp-4366	421	32	-	-	PUNCT
fnp-4366	421	33	defined	define	VERB
fnp-4366	421	34	cluster	cluster	NOUN
fnp-4366	421	35	was	be	AUX
fnp-4366	421	36	apparent	apparent	ADJ
fnp-4366	421	37	.	.	PUNCT
fnp-4366	422	1	accordingly	accordingly	ADV
fnp-4366	422	2	,	,	PUNCT
fnp-4366	422	3	a	a	DET
fnp-4366	422	4	decrease	decrease	NOUN
fnp-4366	422	5	was	be	AUX
fnp-4366	422	6	observed	observe	VERB
fnp-4366	422	7	for	for	ADP
fnp-4366	422	8	tfs	tfs	PROPN
fnp-4366	422	9	associated	associate	VERB
fnp-4366	422	10	with	with	ADP
fnp-4366	422	11	early	early	ADJ
fnp-4366	422	12	state	state	NOUN
fnp-4366	422	13	astrocytic	astrocytic	ADJ
fnp-4366	422	14	differentiation	differentiation	NOUN
fnp-4366	422	15	in	in	ADP
fnp-4366	422	16	cbd	cbd	PROPN
fnp-4366	422	17	,	,	PUNCT
fnp-4366	422	18	while	while	SCONJ
fnp-4366	422	19	tfme	tfme	NOUN
fnp-4366	422	20	of	of	ADP
fnp-4366	422	21	ier	ier	X
fnp-4366	422	22	-	-	PUNCT
fnp-4366	422	23	related	relate	VERB
fnp-4366	422	24	tfs	tfs	NOUN
fnp-4366	422	25	considerably	considerably	ADV
fnp-4366	422	26	increased	increase	VERB
fnp-4366	422	27	along	along	ADP
fnp-4366	422	28	the	the	DET
fnp-4366	422	29	pseudotime	pseudotime	ADJ
fnp-4366	422	30	axis	axis	NOUN
fnp-4366	422	31	.	.	PUNCT
fnp-4366	423	1	conclusions	conclusion	NOUN
fnp-4366	423	2	:	:	PUNCT
fnp-4366	423	3	our	our	PRON
fnp-4366	423	4	study	study	NOUN
fnp-4366	423	5	revealed	reveal	VERB
fnp-4366	423	6	genetic	genetic	ADJ
fnp-4366	423	7	dysregulation	dysregulation	NOUN
fnp-4366	423	8	affecting	affect	VERB
fnp-4366	423	9	neurodegenerative	neurodegenerative	ADJ
fnp-4366	423	10	,	,	PUNCT
fnp-4366	423	11	neuroinflammatory	neuroinflammatory	ADJ
fnp-4366	423	12	and	and	CCONJ
fnp-4366	423	13	degradation	degradation	NOUN
fnp-4366	423	14	processes	process	NOUN
fnp-4366	423	15	and	and	CCONJ
fnp-4366	423	16	particularly	particularly	ADV
fnp-4366	423	17	points	point	VERB
fnp-4366	423	18	to	to	ADP
fnp-4366	423	19	a	a	DET
fnp-4366	423	20	major	major	ADJ
fnp-4366	423	21	role	role	NOUN
fnp-4366	423	22	of	of	ADP
fnp-4366	423	23	astrocytes	astrocyte	NOUN
fnp-4366	423	24	in	in	ADP
fnp-4366	423	25	the	the	DET
fnp-4366	423	26	pathogenesis	pathogenesis	NOUN
fnp-4366	423	27	of	of	ADP
fnp-4366	423	28	psp	psp	NOUN
fnp-4366	423	29	and	and	CCONJ
fnp-4366	423	30	cbd	cbd	PROPN
fnp-4366	423	31	.	.	PUNCT
fnp-4366	424	1	however	however	ADV
fnp-4366	424	2	,	,	PUNCT
fnp-4366	424	3	to	to	PART
fnp-4366	424	4	understand	understand	VERB
fnp-4366	424	5	the	the	DET
fnp-4366	424	6	downstream	downstream	ADJ
fnp-4366	424	7	mechanisms	mechanism	NOUN
fnp-4366	424	8	,	,	PUNCT
fnp-4366	424	9	further	far	ADV
fnp-4366	424	10	independent	independent	ADJ
fnp-4366	424	11	validation	validation	NOUN
fnp-4366	424	12	especially	especially	ADV
fnp-4366	424	13	at	at	ADP
fnp-4366	424	14	the	the	DET
fnp-4366	424	15	transcriptome	transcriptome	NOUN
fnp-4366	424	16	and	and	CCONJ
fnp-4366	424	17	protein	protein	NOUN
fnp-4366	424	18	level	level	NOUN
fnp-4366	424	19	will	will	AUX
fnp-4366	424	20	be	be	AUX
fnp-4366	424	21	necessary	necessary	ADJ
fnp-4366	424	22	.	.	PUNCT
fnp-4366	425	1	github	github	PROPN
fnp-4366	425	2	ressource	ressource	PROPN
fnp-4366	425	3	:	:	PUNCT
fnp-4366	425	4	https://github.com/nes-b/snatac-seq_psp_cbd	https://github.com/nes-b/snatac-seq_psp_cbd	ADJ
fnp-4366	425	5	  	  	SPACE
fnp-4366	425	6	3.08	3.08	NUM
fnp-4366	425	7	free	free	ADJ
fnp-4366	425	8	neuropathol	neuropathol	NOUN
fnp-4366	425	9	3:20:43	3:20:43	NUM
fnp-4366	425	10	application	application	NOUN
fnp-4366	425	11	of	of	ADP
fnp-4366	425	12	a	a	DET
fnp-4366	425	13	human	human	ADJ
fnp-4366	425	14	stem	stem	NOUN
fnp-4366	425	15	cell	cell	NOUN
fnp-4366	425	16	transplantation	transplantation	NOUN
fnp-4366	425	17	model	model	NOUN
fnp-4366	425	18	of	of	ADP
fnp-4366	425	19	alzheimer	alzheimer	PROPN
fnp-4366	425	20	’s	’s	PART
fnp-4366	425	21	disease	disease	NOUN
fnp-4366	425	22	to	to	PART
fnp-4366	425	23	examine	examine	VERB
fnp-4366	425	24	disease	disease	NOUN
fnp-4366	425	25	-	-	PUNCT
fnp-4366	425	26	associated	associate	VERB
fnp-4366	425	27	changes	change	NOUN
fnp-4366	425	28	at	at	ADP
fnp-4366	425	29	a	a	DET
fnp-4366	425	30	single	single	ADJ
fnp-4366	425	31	cell	cell	NOUN
fnp-4366	425	32	level	level	NOUN
fnp-4366	425	33	in	in	ADP
fnp-4366	425	34	vivo	vivo	PROPN
fnp-4366	425	35	wenhui	wenhui	PROPN
fnp-4366	425	36	qu1	qu1	PROPN
fnp-4366	425	37	,	,	PUNCT
fnp-4366	425	38	matti	matti	PROPN
fnp-4366	425	39	lam2	lam2	PROPN
fnp-4366	425	40	,	,	PUNCT
fnp-4366	425	41	aayushi	aayushi	PROPN
fnp-4366	425	42	mahajan3	mahajan3	PROPN
fnp-4366	425	43	,	,	PUNCT
fnp-4366	425	44	nelson	nelson	PROPN
fnp-4366	425	45	humala3	humala3	PROPN
fnp-4366	425	46	,	,	PUNCT
fnp-4366	425	47	osama	osama	PROPN
fnp-4366	425	48	al	al	PROPN
fnp-4366	425	49	dalahmah1	dalahmah1	PROPN
fnp-4366	425	50	,	,	PUNCT
fnp-4366	425	51	jason	jason	PROPN
fnp-4366	425	52	mares2	mares2	PROPN
fnp-4366	425	53	,	,	PUNCT
fnp-4366	425	54	trang	trang	PROPN
fnp-4366	425	55	nguyen1	nguyen1	PROPN
fnp-4366	425	56	,	,	PUNCT
fnp-4366	425	57	ismael	ismael	PROPN
fnp-4366	425	58	santa	santa	PROPN
fnp-4366	425	59	-	-	PUNCT
fnp-4366	425	60	maria1	maria1	PROPN
fnp-4366	425	61	,	,	PUNCT
fnp-4366	425	62	andrew	andrew	PROPN
fnp-4366	425	63	sproul1	sproul1	PROPN
fnp-4366	425	64	,	,	PUNCT
fnp-4366	425	65	markus	markus	NOUN
fnp-4366	425	66	siegelin1	siegelin1	PROPN
fnp-4366	425	67	,	,	PUNCT
fnp-4366	425	68	james	james	PROPN
fnp-4366	425	69	goldman1	goldman1	PROPN
fnp-4366	425	70	,	,	PUNCT
fnp-4366	425	71	peter	peter	PROPN
fnp-4366	425	72	canoll1	canoll1	PROPN
fnp-4366	425	73	,	,	PUNCT
fnp-4366	425	74	vilas	vilas	PROPN
fnp-4366	425	75	menon2	menon2	PROPN
fnp-4366	425	76	,	,	PUNCT
fnp-4366	425	77	gunnar	gunnar	VERB
fnp-4366	425	78	hargus1	hargus1	PROPN
fnp-4366	425	79	1	1	NUM
fnp-4366	425	80	columbia	columbia	PROPN
fnp-4366	425	81	university	university	PROPN
fnp-4366	425	82	medical	medical	ADJ
fnp-4366	425	83	center	center	NOUN
fnp-4366	425	84	,	,	PUNCT
fnp-4366	425	85	department	department	NOUN
fnp-4366	425	86	of	of	ADP
fnp-4366	425	87	pathology	pathology	NOUN
fnp-4366	425	88	and	and	CCONJ
fnp-4366	425	89	cell	cell	NOUN
fnp-4366	425	90	biology	biology	NOUN
fnp-4366	425	91	,	,	PUNCT
fnp-4366	425	92	new	new	PROPN
fnp-4366	425	93	york	york	PROPN
fnp-4366	425	94	,	,	PUNCT
fnp-4366	425	95	united	united	PROPN
fnp-4366	425	96	states	states	PROPN
fnp-4366	425	97	2	2	NUM
fnp-4366	425	98	columbia	columbia	PROPN
fnp-4366	425	99	university	university	PROPN
fnp-4366	425	100	medical	medical	ADJ
fnp-4366	425	101	center	center	NOUN
fnp-4366	425	102	,	,	PUNCT
fnp-4366	425	103	department	department	NOUN
fnp-4366	425	104	of	of	ADP
fnp-4366	425	105	neurology	neurology	NOUN
fnp-4366	425	106	,	,	PUNCT
fnp-4366	425	107	new	new	PROPN
fnp-4366	425	108	york	york	PROPN
fnp-4366	425	109	,	,	PUNCT
fnp-4366	425	110	united	united	PROPN
fnp-4366	425	111	states	states	PROPN
fnp-4366	425	112	3	3	NUM
fnp-4366	425	113	columbia	columbia	PROPN
fnp-4366	425	114	university	university	PROPN
fnp-4366	425	115	medical	medical	ADJ
fnp-4366	425	116	center	center	NOUN
fnp-4366	425	117	,	,	PUNCT
fnp-4366	425	118	department	department	NOUN
fnp-4366	425	119	of	of	ADP
fnp-4366	425	120	neurosurgery	neurosurgery	NOUN
fnp-4366	425	121	,	,	PUNCT
fnp-4366	425	122	new	new	PROPN
fnp-4366	425	123	york	york	PROPN
fnp-4366	425	124	,	,	PUNCT
fnp-4366	425	125	united	united	PROPN
fnp-4366	425	126	states	states	PROPN
fnp-4366	425	127	background	background	NOUN
fnp-4366	425	128	:	:	PUNCT
fnp-4366	425	129	alzheimer	alzheimer	PROPN
fnp-4366	425	130	’s	’s	PART
fnp-4366	425	131	disease	disease	NOUN
fnp-4366	425	132	(	(	PUNCT
fnp-4366	425	133	ad	ad	NOUN
fnp-4366	425	134	)	)	PUNCT
fnp-4366	425	135	is	be	AUX
fnp-4366	425	136	the	the	DET
fnp-4366	425	137	most	most	ADV
fnp-4366	425	138	common	common	ADJ
fnp-4366	425	139	type	type	NOUN
fnp-4366	425	140	of	of	ADP
fnp-4366	425	141	dementia	dementia	NOUN
fnp-4366	425	142	and	and	CCONJ
fnp-4366	425	143	is	be	AUX
fnp-4366	425	144	characterized	characterize	VERB
fnp-4366	425	145	by	by	ADP
fnp-4366	425	146	widespread	widespread	ADJ
fnp-4366	425	147	degeneration	degeneration	NOUN
fnp-4366	425	148	of	of	ADP
fnp-4366	425	149	the	the	DET
fnp-4366	425	150	central	central	ADJ
fnp-4366	425	151	nervous	nervous	ADJ
fnp-4366	425	152	system	system	NOUN
fnp-4366	425	153	with	with	ADP
fnp-4366	425	154	amyloid	amyloid	NOUN
fnp-4366	425	155	and	and	CCONJ
fnp-4366	425	156	tau	tau	PROPN
fnp-4366	425	157	pathology	pathology	NOUN
fnp-4366	425	158	leading	lead	VERB
fnp-4366	425	159	to	to	ADP
fnp-4366	425	160	severe	severe	ADJ
fnp-4366	425	161	impairment	impairment	NOUN
fnp-4366	425	162	of	of	ADP
fnp-4366	425	163	learning	learning	NOUN
fnp-4366	425	164	and	and	CCONJ
fnp-4366	425	165	memory	memory	NOUN
fnp-4366	425	166	.	.	PUNCT
fnp-4366	426	1	despite	despite	SCONJ
fnp-4366	426	2	the	the	DET
fnp-4366	426	3	high	high	ADJ
fnp-4366	426	4	number	number	NOUN
fnp-4366	426	5	of	of	ADP
fnp-4366	426	6	patients	patient	NOUN
fnp-4366	426	7	with	with	ADP
fnp-4366	426	8	ad	ad	NOUN
fnp-4366	426	9	,	,	PUNCT
fnp-4366	426	10	the	the	DET
fnp-4366	426	11	molecular	molecular	ADJ
fnp-4366	426	12	mechanisms	mechanism	NOUN
fnp-4366	426	13	leading	lead	VERB
fnp-4366	426	14	to	to	ADP
fnp-4366	426	15	neurodegeneration	neurodegeneration	NOUN
fnp-4366	426	16	are	be	AUX
fnp-4366	426	17	only	only	ADV
fnp-4366	426	18	partially	partially	ADV
fnp-4366	426	19	understood	understand	VERB
fnp-4366	426	20	and	and	CCONJ
fnp-4366	426	21	effective	effective	ADJ
fnp-4366	426	22	treatment	treatment	NOUN
fnp-4366	426	23	options	option	NOUN
fnp-4366	426	24	still	still	ADV
fnp-4366	426	25	do	do	AUX
fnp-4366	426	26	not	not	PART
fnp-4366	426	27	exist	exist	VERB
fnp-4366	426	28	.	.	PUNCT
fnp-4366	427	1	aims	aim	NOUN
fnp-4366	427	2	/	/	SYM
fnp-4366	427	3	questions	question	NOUN
fnp-4366	427	4	:	:	PUNCT
fnp-4366	427	5	here	here	ADV
fnp-4366	427	6	,	,	PUNCT
fnp-4366	427	7	we	we	PRON
fnp-4366	427	8	applied	apply	VERB
fnp-4366	427	9	a	a	DET
fnp-4366	427	10	human	human	ADJ
fnp-4366	427	11	stem	stem	NOUN
fnp-4366	427	12	cell	cell	NOUN
fnp-4366	427	13	model	model	NOUN
fnp-4366	427	14	of	of	ADP
fnp-4366	427	15	ad	ad	NOUN
fnp-4366	427	16	to	to	PART
fnp-4366	427	17	study	study	VERB
fnp-4366	427	18	disease	disease	NOUN
fnp-4366	427	19	-	-	PUNCT
fnp-4366	427	20	modifying	modify	VERB
fnp-4366	427	21	roles	role	NOUN
fnp-4366	427	22	of	of	ADP
fnp-4366	427	23	neural	neural	ADJ
fnp-4366	427	24	cells	cell	NOUN
fnp-4366	427	25	at	at	ADP
fnp-4366	427	26	a	a	DET
fnp-4366	427	27	single	single	ADJ
fnp-4366	427	28	cell	cell	NOUN
fnp-4366	427	29	level	level	NOUN
fnp-4366	427	30	in	in	ADP
fnp-4366	427	31	vivo	vivo	NOUN
fnp-4366	427	32	.	.	PUNCT
fnp-4366	428	1	methods	method	NOUN
fnp-4366	428	2	:	:	PUNCT
fnp-4366	428	3	to	to	ADP
fnp-4366	428	4	this	this	DET
fnp-4366	428	5	end	end	NOUN
fnp-4366	428	6	,	,	PUNCT
fnp-4366	428	7	we	we	PRON
fnp-4366	428	8	differentiated	differentiate	VERB
fnp-4366	428	9	induced	induced	ADJ
fnp-4366	428	10	pluripotent	pluripotent	ADJ
fnp-4366	428	11	stem	stem	NOUN
fnp-4366	428	12	cells	cell	NOUN
fnp-4366	428	13	(	(	PUNCT
fnp-4366	428	14	ipscs	ipsc	NOUN
fnp-4366	428	15	)	)	PUNCT
fnp-4366	428	16	with	with	ADP
fnp-4366	428	17	the	the	DET
fnp-4366	428	18	familial	familial	ADJ
fnp-4366	428	19	ad	ad	NOUN
fnp-4366	428	20	-	-	PUNCT
fnp-4366	428	21	associated	associate	VERB
fnp-4366	428	22	appv717i	appv717i	PROPN
fnp-4366	428	23	mutation	mutation	NOUN
fnp-4366	428	24	in	in	ADP
fnp-4366	428	25	the	the	DET
fnp-4366	428	26	amyloid	amyloid	NOUN
fnp-4366	428	27	precursor	precursor	NOUN
fnp-4366	428	28	protein	protein	NOUN
fnp-4366	428	29	as	as	ADV
fnp-4366	428	30	well	well	ADV
fnp-4366	428	31	as	as	ADP
fnp-4366	428	32	isogenic	isogenic	ADJ
fnp-4366	428	33	control	control	NOUN
fnp-4366	428	34	cells	cell	NOUN
fnp-4366	428	35	into	into	ADP
fnp-4366	428	36	neural	neural	ADJ
fnp-4366	428	37	progenitor	progenitor	NOUN
fnp-4366	428	38	cells	cell	NOUN
fnp-4366	428	39	(	(	PUNCT
fnp-4366	428	40	npcs	npc	NOUN
fnp-4366	428	41	)	)	PUNCT
fnp-4366	428	42	and	and	CCONJ
fnp-4366	428	43	neurons	neuron	NOUN
fnp-4366	428	44	.	.	PUNCT
fnp-4366	429	1	results	result	NOUN
fnp-4366	429	2	:	:	PUNCT
fnp-4366	429	3	appv717i	appv717i	PROPN
fnp-4366	429	4	neurons	neuron	NOUN
fnp-4366	429	5	showed	show	VERB
fnp-4366	429	6	reduced	reduce	VERB
fnp-4366	429	7	neurite	neurite	ADJ
fnp-4366	429	8	outgrowth	outgrowth	NOUN
fnp-4366	429	9	and	and	CCONJ
fnp-4366	429	10	demonstrated	demonstrate	VERB
fnp-4366	429	11	an	an	DET
fnp-4366	429	12	increased	increase	VERB
fnp-4366	429	13	susceptibility	susceptibility	NOUN
fnp-4366	429	14	towards	towards	ADP
fnp-4366	429	15	oxidative	oxidative	ADJ
fnp-4366	429	16	stress	stress	NOUN
fnp-4366	429	17	with	with	ADP
fnp-4366	429	18	changes	change	NOUN
fnp-4366	429	19	in	in	ADP
fnp-4366	429	20	metabolic	metabolic	NOUN
fnp-4366	429	21	programs	program	NOUN
fnp-4366	429	22	.	.	PUNCT
fnp-4366	430	1	we	we	PRON
fnp-4366	430	2	injected	inject	VERB
fnp-4366	430	3	appv717i	appv717i	PROPN
fnp-4366	430	4	and	and	CCONJ
fnp-4366	430	5	control	control	VERB
fnp-4366	430	6	npcs	npc	NOUN
fnp-4366	430	7	into	into	ADP
fnp-4366	430	8	the	the	DET
fnp-4366	430	9	brains	brain	NOUN
fnp-4366	430	10	of	of	ADP
fnp-4366	430	11	immunocompromised	immunocompromise	VERB
fnp-4366	430	12	nsg	nsg	PROPN
fnp-4366	430	13	mice	mouse	NOUN
fnp-4366	430	14	resulting	result	VERB
fnp-4366	430	15	in	in	ADP
fnp-4366	430	16	neuronal	neuronal	ADJ
fnp-4366	430	17	grafts	graft	NOUN
fnp-4366	430	18	in	in	ADP
fnp-4366	430	19	both	both	DET
fnp-4366	430	20	groups	group	NOUN
fnp-4366	430	21	two	two	NUM
fnp-4366	430	22	months	month	NOUN
fnp-4366	430	23	after	after	ADP
fnp-4366	430	24	injection	injection	NOUN
fnp-4366	430	25	with	with	ADP
fnp-4366	430	26	activation	activation	NOUN
fnp-4366	430	27	of	of	ADP
fnp-4366	430	28	microglial	microglial	ADJ
fnp-4366	430	29	cells	cell	NOUN
fnp-4366	430	30	and	and	CCONJ
fnp-4366	430	31	presence	presence	NOUN
fnp-4366	430	32	of	of	ADP
fnp-4366	430	33	reactive	reactive	ADJ
fnp-4366	430	34	astrocytes	astrocyte	NOUN
fnp-4366	430	35	within	within	ADP
fnp-4366	430	36	and	and	CCONJ
fnp-4366	430	37	around	around	ADP
fnp-4366	430	38	the	the	DET
fnp-4366	430	39	grafts	graft	NOUN
fnp-4366	430	40	.	.	PUNCT
fnp-4366	431	1	we	we	PRON
fnp-4366	431	2	then	then	ADV
fnp-4366	431	3	performed	perform	VERB
fnp-4366	431	4	single	single	ADJ
fnp-4366	431	5	nucleus	nucleus	PROPN
fnp-4366	431	6	rna	rna	NOUN
fnp-4366	431	7	sequencing	sequence	VERB
fnp-4366	431	8	(	(	PUNCT
fnp-4366	431	9	snrna	snrna	ADJ
fnp-4366	431	10	-	-	PUNCT
fnp-4366	431	11	seq	seq	NOUN
fnp-4366	431	12	)	)	PUNCT
fnp-4366	431	13	on	on	ADP
fnp-4366	431	14	microdissected	microdissected	ADJ
fnp-4366	431	15	grafts	graft	NOUN
fnp-4366	431	16	to	to	PART
fnp-4366	431	17	characterize	characterize	VERB
fnp-4366	431	18	gene	gene	NOUN
fnp-4366	431	19	expression	expression	NOUN
fnp-4366	431	20	and	and	CCONJ
fnp-4366	431	21	dysregulated	dysregulated	ADJ
fnp-4366	431	22	pathways	pathway	NOUN
fnp-4366	431	23	in	in	ADP
fnp-4366	431	24	appv717i	appv717i	PROPN
fnp-4366	431	25	versus	versus	ADP
fnp-4366	431	26	control	control	NOUN
fnp-4366	431	27	neurons	neuron	NOUN
fnp-4366	431	28	as	as	ADV
fnp-4366	431	29	well	well	ADV
fnp-4366	431	30	as	as	ADP
fnp-4366	431	31	in	in	ADP
fnp-4366	431	32	astroglial	astroglial	ADJ
fnp-4366	431	33	cells	cell	NOUN
fnp-4366	431	34	and	and	CCONJ
fnp-4366	431	35	microglia	microglia	NOUN
fnp-4366	431	36	in	in	ADP
fnp-4366	431	37	response	response	NOUN
fnp-4366	431	38	to	to	ADP
fnp-4366	431	39	appv717i	appv717i	PROPN
fnp-4366	431	40	and	and	CCONJ
fnp-4366	431	41	control	control	NOUN
fnp-4366	431	42	neurons	neuron	NOUN
fnp-4366	431	43	at	at	ADP
fnp-4366	431	44	a	a	DET
fnp-4366	431	45	single	single	ADJ
fnp-4366	431	46	cell	cell	NOUN
fnp-4366	431	47	level	level	NOUN
fnp-4366	431	48	.	.	PUNCT
fnp-4366	432	1	conclusions	conclusion	NOUN
fnp-4366	432	2	:	:	PUNCT
fnp-4366	432	3	our	our	PRON
fnp-4366	432	4	findings	finding	NOUN
fnp-4366	432	5	show	show	VERB
fnp-4366	432	6	that	that	SCONJ
fnp-4366	432	7	ipscs	ipsc	NOUN
fnp-4366	432	8	represent	represent	VERB
fnp-4366	432	9	a	a	DET
fnp-4366	432	10	powerful	powerful	ADJ
fnp-4366	432	11	cell	cell	NOUN
fnp-4366	432	12	source	source	NOUN
fnp-4366	432	13	to	to	PART
fnp-4366	432	14	study	study	VERB
fnp-4366	432	15	mechanisms	mechanism	NOUN
fnp-4366	432	16	of	of	ADP
fnp-4366	432	17	disease	disease	NOUN
fnp-4366	432	18	development	development	NOUN
fnp-4366	432	19	in	in	ADP
fnp-4366	432	20	vitro	vitro	X
fnp-4366	432	21	and	and	CCONJ
fnp-4366	432	22	in	in	ADP
fnp-4366	432	23	vivo	vivo	NOUN
fnp-4366	432	24	.	.	PUNCT
fnp-4366	433	1	this	this	DET
fnp-4366	433	2	stem	stem	NOUN
fnp-4366	433	3	cell	cell	NOUN
fnp-4366	433	4	model	model	NOUN
fnp-4366	433	5	of	of	ADP
fnp-4366	433	6	ad	ad	NOUN
fnp-4366	433	7	could	could	AUX
fnp-4366	433	8	also	also	ADV
fnp-4366	433	9	be	be	AUX
fnp-4366	433	10	used	use	VERB
fnp-4366	433	11	as	as	ADP
fnp-4366	433	12	a	a	DET
fnp-4366	433	13	cellular	cellular	ADJ
fnp-4366	433	14	platform	platform	NOUN
fnp-4366	433	15	for	for	ADP
fnp-4366	433	16	high	high	ADJ
fnp-4366	433	17	-	-	PUNCT
fnp-4366	433	18	throughput	throughput	NOUN
fnp-4366	433	19	drug	drug	NOUN
fnp-4366	433	20	screening	screen	VERB
fnp-4366	433	21	purposes	purpose	NOUN
fnp-4366	433	22	to	to	PART
fnp-4366	433	23	identify	identify	VERB
fnp-4366	433	24	potential	potential	ADJ
fnp-4366	433	25	therapeutic	therapeutic	ADJ
fnp-4366	433	26	targets	target	NOUN
fnp-4366	433	27	in	in	ADP
fnp-4366	433	28	ad	ad	NOUN
fnp-4366	433	29	.	.	PUNCT
fnp-4366	433	30	  	  	SPACE
fnp-4366	434	1	4	4	NUM
fnp-4366	434	2	.	.	X
fnp-4366	434	3	neuroinflammation	neuroinflammation	NOUN
fnp-4366	434	4	4.01	4.01	NUM
fnp-4366	434	5	free	free	ADJ
fnp-4366	434	6	neuropathol	neuropathol	NOUN
fnp-4366	434	7	3:20:44	3:20:44	NUM
fnp-4366	434	8	pathological	pathological	ADJ
fnp-4366	434	9	and	and	CCONJ
fnp-4366	434	10	genetic	genetic	ADJ
fnp-4366	434	11	characterization	characterization	NOUN
fnp-4366	434	12	of	of	ADP
fnp-4366	434	13	jc	jc	PROPN
fnp-4366	434	14	virus	virus	NOUN
fnp-4366	434	15	encephalopathy	encephalopathy	ADJ
fnp-4366	434	16	with	with	ADP
fnp-4366	434	17	an	an	DET
fnp-4366	434	18	eleven	eleven	NUM
fnp-4366	434	19	-	-	PUNCT
fnp-4366	434	20	year	year	NOUN
fnp-4366	434	21	-	-	PUNCT
fnp-4366	434	22	long	long	ADJ
fnp-4366	434	23	disease	disease	NOUN
fnp-4366	434	24	course	course	NOUN
fnp-4366	434	25	marco	marco	PROPN
fnp-4366	434	26	mlynek1	mlynek1	PROPN
fnp-4366	434	27	,	,	PUNCT
fnp-4366	434	28	adriane	adriane	PROPN
fnp-4366	434	29	kuttlovci1	kuttlovci1	PROPN
fnp-4366	434	30	,	,	PUNCT
fnp-4366	434	31	marek	marek	PROPN
fnp-4366	434	32	jauß2	jauß2	PROPN
fnp-4366	434	33	,	,	PUNCT
fnp-4366	434	34	cornelia	cornelia	PROPN
fnp-4366	434	35	tennstedt	tennstedt	PROPN
fnp-4366	434	36	-	-	PUNCT
fnp-4366	434	37	schenk3	schenk3	PROPN
fnp-4366	434	38	,	,	PUNCT
fnp-4366	434	39	lidia	lidia	PROPN
fnp-4366	434	40	stork1	stork1	PROPN
fnp-4366	434	41	,	,	PUNCT
fnp-4366	434	42	christine	christine	PROPN
fnp-4366	434	43	stadelmann1	stadelmann1	PROPN
fnp-4366	434	44	,	,	PUNCT
fnp-4366	434	45	imke	imke	PROPN
fnp-4366	434	46	metz1	metz1	NOUN
fnp-4366	434	47	1	1	NUM
fnp-4366	435	1	institut	institut	PROPN
fnp-4366	435	2	für	für	PROPN
fnp-4366	435	3	neuropathologie	neuropathologie	PROPN
fnp-4366	435	4	universitätsmedizin	universitätsmedizin	PROPN
fnp-4366	435	5	göttingen	göttingen	PROPN
fnp-4366	435	6	,	,	PUNCT
fnp-4366	435	7	göttingen	göttingen	NOUN
fnp-4366	435	8	,	,	PUNCT
fnp-4366	435	9	deutschland	deutschland	NOUN
fnp-4366	435	10	2	2	NUM
fnp-4366	435	11	ökumenisches	ökumenische	NOUN
fnp-4366	435	12	hainich	hainich	PROPN
fnp-4366	435	13	klinikum	klinikum	PROPN
fnp-4366	435	14	ggmbh	ggmbh	PROPN
fnp-4366	435	15	,	,	PUNCT
fnp-4366	435	16	mühlhausen	mühlhausen	PROPN
fnp-4366	435	17	/	/	SYM
fnp-4366	435	18	thüringen	thüringen	PROPN
fnp-4366	435	19	,	,	PUNCT
fnp-4366	435	20	deutschland	deutschland	NOUN
fnp-4366	435	21	3	3	NUM
fnp-4366	435	22	institut	institut	PROPN
fnp-4366	435	23	für	für	PROPN
fnp-4366	435	24	pathologie	pathologie	PROPN
fnp-4366	435	25	,	,	PUNCT
fnp-4366	435	26	mühlhausen	mühlhausen	PROPN
fnp-4366	435	27	/	/	SYM
fnp-4366	435	28	thüringen	thüringen	PROPN
fnp-4366	435	29	,	,	PUNCT
fnp-4366	435	30	deutschland	deutschland	VERB
fnp-4366	435	31	the	the	DET
fnp-4366	435	32	jc	jc	PROPN
fnp-4366	435	33	polyomavirus	polyomavirus	PROPN
fnp-4366	435	34	(	(	PUNCT
fnp-4366	435	35	jcpyv	jcpyv	NOUN
fnp-4366	435	36	)	)	PUNCT
fnp-4366	435	37	typically	typically	ADV
fnp-4366	435	38	causes	cause	VERB
fnp-4366	435	39	progressive	progressive	ADJ
fnp-4366	435	40	multifocal	multifocal	ADJ
fnp-4366	435	41	leukoencephalopathy	leukoencephalopathy	NOUN
fnp-4366	435	42	(	(	PUNCT
fnp-4366	435	43	pml	pml	NOUN
fnp-4366	435	44	)	)	PUNCT
fnp-4366	435	45	in	in	ADP
fnp-4366	435	46	immunocompromised	immunocompromise	VERB
fnp-4366	435	47	humans	human	NOUN
fnp-4366	435	48	.	.	PUNCT
fnp-4366	436	1	the	the	DET
fnp-4366	436	2	pathology	pathology	NOUN
fnp-4366	436	3	shows	show	VERB
fnp-4366	436	4	demyelinated	demyelinate	VERB
fnp-4366	436	5	white	white	ADJ
fnp-4366	436	6	matter	matter	NOUN
fnp-4366	436	7	lesions	lesion	NOUN
fnp-4366	436	8	with	with	ADP
fnp-4366	436	9	infection	infection	NOUN
fnp-4366	436	10	of	of	ADP
fnp-4366	436	11	glial	glial	ADJ
fnp-4366	436	12	cells	cell	NOUN
fnp-4366	436	13	,	,	PUNCT
fnp-4366	436	14	but	but	CCONJ
fnp-4366	436	15	very	very	ADV
fnp-4366	436	16	few	few	ADJ
fnp-4366	436	17	infected	infected	ADJ
fnp-4366	436	18	cortical	cortical	ADJ
fnp-4366	436	19	pyramidal	pyramidal	ADJ
fnp-4366	436	20	neurons	neuron	NOUN
fnp-4366	436	21	.	.	PUNCT
fnp-4366	437	1	in	in	ADP
fnp-4366	437	2	contrast	contrast	NOUN
fnp-4366	437	3	,	,	PUNCT
fnp-4366	437	4	another	another	DET
fnp-4366	437	5	jcpyv	jcpyv	NOUN
fnp-4366	437	6	-	-	PUNCT
fnp-4366	437	7	associated	associate	VERB
fnp-4366	437	8	disease	disease	NOUN
fnp-4366	437	9	is	be	AUX
fnp-4366	437	10	jc	jc	PROPN
fnp-4366	437	11	virus	virus	NOUN
fnp-4366	437	12	encephalopathy	encephalopathy	ADV
fnp-4366	437	13	(	(	PUNCT
fnp-4366	437	14	jcve	jcve	PROPN
fnp-4366	437	15	)	)	PUNCT
fnp-4366	437	16	,	,	PUNCT
fnp-4366	437	17	which	which	PRON
fnp-4366	437	18	is	be	AUX
fnp-4366	437	19	characterized	characterize	VERB
fnp-4366	437	20	by	by	ADP
fnp-4366	437	21	numerous	numerous	ADJ
fnp-4366	437	22	infected	infected	ADJ
fnp-4366	437	23	neurons	neuron	NOUN
fnp-4366	437	24	.	.	PUNCT
fnp-4366	438	1	while	while	SCONJ
fnp-4366	438	2	the	the	DET
fnp-4366	438	3	non	non	ADJ
fnp-4366	438	4	-	-	ADJ
fnp-4366	438	5	coding	coding	ADJ
fnp-4366	438	6	control	control	NOUN
fnp-4366	438	7	region	region	NOUN
fnp-4366	438	8	of	of	ADP
fnp-4366	438	9	jcpyv	jcpyv	NOUN
fnp-4366	438	10	in	in	ADP
fnp-4366	438	11	pml	pml	PROPN
fnp-4366	438	12	shows	show	VERB
fnp-4366	438	13	genetic	genetic	ADJ
fnp-4366	438	14	rearrangements	rearrangement	NOUN
fnp-4366	438	15	(	(	PUNCT
fnp-4366	438	16	so	so	ADV
fnp-4366	438	17	-	-	PUNCT
fnp-4366	438	18	called	call	VERB
fnp-4366	438	19	prototype	prototype	NOUN
fnp-4366	438	20	)	)	PUNCT
fnp-4366	438	21	,	,	PUNCT
fnp-4366	438	22	in	in	ADP
fnp-4366	438	23	jcve	jcve	NOUN
fnp-4366	438	24	the	the	DET
fnp-4366	438	25	archetype	archetype	NOUN
fnp-4366	438	26	virus	virus	NOUN
fnp-4366	438	27	is	be	AUX
fnp-4366	438	28	found	find	VERB
fnp-4366	438	29	,	,	PUNCT
fnp-4366	438	30	which	which	PRON
fnp-4366	438	31	is	be	AUX
fnp-4366	438	32	also	also	ADV
fnp-4366	438	33	present	present	ADJ
fnp-4366	438	34	in	in	ADP
fnp-4366	438	35	healthy	healthy	ADJ
fnp-4366	438	36	individuals	individual	NOUN
fnp-4366	438	37	.	.	PUNCT
fnp-4366	439	1	we	we	PRON
fnp-4366	439	2	provide	provide	VERB
fnp-4366	439	3	a	a	DET
fnp-4366	439	4	detailed	detailed	ADJ
fnp-4366	439	5	clinical	clinical	NOUN
fnp-4366	439	6	,	,	PUNCT
fnp-4366	439	7	(	(	PUNCT
fnp-4366	439	8	histo)pathological	histo)pathological	ADJ
fnp-4366	439	9	and	and	CCONJ
fnp-4366	439	10	genetic	genetic	ADJ
fnp-4366	439	11	description	description	NOUN
fnp-4366	439	12	of	of	ADP
fnp-4366	439	13	a	a	DET
fnp-4366	439	14	patient	patient	NOUN
fnp-4366	439	15	with	with	ADP
fnp-4366	439	16	jcve	jcve	NOUN
fnp-4366	439	17	.	.	PUNCT
fnp-4366	440	1	we	we	PRON
fnp-4366	440	2	analyzed	analyze	VERB
fnp-4366	440	3	different	different	ADJ
fnp-4366	440	4	lesion	lesion	NOUN
fnp-4366	440	5	areas	area	NOUN
fnp-4366	440	6	for	for	ADP
fnp-4366	440	7	viral	viral	ADJ
fnp-4366	440	8	infection	infection	NOUN
fnp-4366	440	9	and	and	CCONJ
fnp-4366	440	10	replication	replication	NOUN
fnp-4366	440	11	of	of	ADP
fnp-4366	440	12	glial	glial	ADJ
fnp-4366	440	13	and	and	CCONJ
fnp-4366	440	14	neuronal	neuronal	ADJ
fnp-4366	440	15	cells	cell	NOUN
fnp-4366	440	16	.	.	PUNCT
fnp-4366	441	1	in	in	ADP
fnp-4366	441	2	addition	addition	NOUN
fnp-4366	441	3	,	,	PUNCT
fnp-4366	441	4	demyelination	demyelination	NOUN
fnp-4366	441	5	,	,	PUNCT
fnp-4366	441	6	cell	cell	NOUN
fnp-4366	441	7	loss	loss	NOUN
fnp-4366	441	8	and	and	CCONJ
fnp-4366	441	9	axonal	axonal	ADJ
fnp-4366	441	10	damage	damage	NOUN
fnp-4366	441	11	were	be	AUX
fnp-4366	441	12	investigated	investigate	VERB
fnp-4366	441	13	.	.	PUNCT
fnp-4366	442	1	we	we	PRON
fnp-4366	442	2	present	present	VERB
fnp-4366	442	3	a	a	DET
fnp-4366	442	4	54	54	NUM
fnp-4366	442	5	-	-	PUNCT
fnp-4366	442	6	year	year	NOUN
fnp-4366	442	7	-	-	PUNCT
fnp-4366	442	8	old	old	ADJ
fnp-4366	442	9	male	male	ADJ
fnp-4366	442	10	patient	patient	NOUN
fnp-4366	442	11	with	with	ADP
fnp-4366	442	12	an	an	DET
fnp-4366	442	13	exceptionally	exceptionally	ADV
fnp-4366	442	14	long	long	ADJ
fnp-4366	442	15	disease	disease	NOUN
fnp-4366	442	16	course	course	NOUN
fnp-4366	442	17	over	over	ADP
fnp-4366	442	18	eleven	eleven	NUM
fnp-4366	442	19	years	year	NOUN
fnp-4366	442	20	who	who	PRON
fnp-4366	442	21	was	be	AUX
fnp-4366	442	22	diagnosed	diagnose	VERB
fnp-4366	442	23	with	with	ADP
fnp-4366	442	24	jcve	jcve	NOUN
fnp-4366	442	25	.	.	PUNCT
fnp-4366	443	1	he	he	PRON
fnp-4366	443	2	developed	develop	VERB
fnp-4366	443	3	slowly	slowly	ADV
fnp-4366	443	4	progressing	progress	VERB
fnp-4366	443	5	myoclonia	myoclonia	NOUN
fnp-4366	443	6	,	,	PUNCT
fnp-4366	443	7	numbness	numbness	NOUN
fnp-4366	443	8	of	of	ADP
fnp-4366	443	9	the	the	DET
fnp-4366	443	10	upper	upper	ADJ
fnp-4366	443	11	and	and	CCONJ
fnp-4366	443	12	lower	low	ADJ
fnp-4366	443	13	extremities	extremity	NOUN
fnp-4366	443	14	,	,	PUNCT
fnp-4366	443	15	pharmacoresistant	pharmacoresistant	ADJ
fnp-4366	443	16	seizures	seizure	NOUN
fnp-4366	443	17	and	and	CCONJ
fnp-4366	443	18	a	a	DET
fnp-4366	443	19	general	general	ADJ
fnp-4366	443	20	cognitive	cognitive	ADJ
fnp-4366	443	21	decline	decline	NOUN
fnp-4366	443	22	.	.	PUNCT
fnp-4366	444	1	mri	mri	NOUN
fnp-4366	444	2	showed	show	VERB
fnp-4366	444	3	a	a	DET
fnp-4366	444	4	progressive	progressive	ADJ
fnp-4366	444	5	atrophy	atrophy	NOUN
fnp-4366	444	6	of	of	ADP
fnp-4366	444	7	the	the	DET
fnp-4366	444	8	cortex	cortex	NOUN
fnp-4366	444	9	with	with	ADP
fnp-4366	444	10	cortical	cortical	ADJ
fnp-4366	444	11	and	and	CCONJ
fnp-4366	444	12	subcortical	subcortical	ADJ
fnp-4366	444	13	parenchymal	parenchymal	ADJ
fnp-4366	444	14	lesions	lesion	NOUN
fnp-4366	444	15	.	.	PUNCT
fnp-4366	445	1	there	there	PRON
fnp-4366	445	2	was	be	VERB
fnp-4366	445	3	no	no	DET
fnp-4366	445	4	clear	clear	ADJ
fnp-4366	445	5	evidence	evidence	NOUN
fnp-4366	445	6	of	of	ADP
fnp-4366	445	7	immunosuppression	immunosuppression	NOUN
fnp-4366	445	8	.	.	PUNCT
fnp-4366	446	1	a	a	DET
fnp-4366	446	2	variant	variant	NOUN
fnp-4366	446	3	of	of	ADP
fnp-4366	446	4	unclear	unclear	ADJ
fnp-4366	446	5	significance	significance	NOUN
fnp-4366	446	6	in	in	ADP
fnp-4366	446	7	the	the	DET
fnp-4366	446	8	interferon	interferon	NOUN
fnp-4366	446	9	-	-	PUNCT
fnp-4366	446	10	induced	induce	VERB
fnp-4366	446	11	with	with	ADP
fnp-4366	446	12	helicase	helicase	NOUN
fnp-4366	446	13	c	c	NOUN
fnp-4366	446	14	domain	domain	NOUN
fnp-4366	446	15	1	1	NUM
fnp-4366	446	16	(	(	PUNCT
fnp-4366	446	17	ifih1	ifih1	NOUN
fnp-4366	446	18	)	)	PUNCT
fnp-4366	446	19	gene	gene	NOUN
fnp-4366	446	20	was	be	AUX
fnp-4366	446	21	found	find	VERB
fnp-4366	446	22	.	.	PUNCT
fnp-4366	447	1	he	he	PRON
fnp-4366	447	2	died	die	VERB
fnp-4366	447	3	due	due	ADJ
fnp-4366	447	4	to	to	ADP
fnp-4366	447	5	status	status	NOUN
fnp-4366	447	6	epilepticus	epilepticus	NOUN
fnp-4366	447	7	and	and	CCONJ
fnp-4366	447	8	pneumonia	pneumonia	NOUN
fnp-4366	447	9	.	.	PUNCT
fnp-4366	448	1	macroscopy	macroscopy	NOUN
fnp-4366	448	2	showed	show	VERB
fnp-4366	448	3	extensive	extensive	ADJ
fnp-4366	448	4	cystic	cystic	ADJ
fnp-4366	448	5	white	white	ADJ
fnp-4366	448	6	matter	matter	NOUN
fnp-4366	448	7	lesions	lesion	NOUN
fnp-4366	448	8	with	with	ADP
fnp-4366	448	9	preservation	preservation	NOUN
fnp-4366	448	10	of	of	ADP
fnp-4366	448	11	the	the	DET
fnp-4366	448	12	cortical	cortical	ADJ
fnp-4366	448	13	ribbon	ribbon	NOUN
fnp-4366	448	14	(	(	PUNCT
fnp-4366	448	15	figure	figure	NOUN
fnp-4366	448	16	1a	1a	NOUN
fnp-4366	448	17	)	)	PUNCT
fnp-4366	448	18	.	.	PUNCT
fnp-4366	449	1	histology	histology	NOUN
fnp-4366	449	2	revealed	reveal	VERB
fnp-4366	449	3	in	in	ADP
fnp-4366	449	4	addition	addition	NOUN
fnp-4366	449	5	lesions	lesion	NOUN
fnp-4366	449	6	with	with	ADP
fnp-4366	449	7	ongoing	ongoing	ADJ
fnp-4366	449	8	viral	viral	ADJ
fnp-4366	449	9	infection	infection	NOUN
fnp-4366	449	10	.	.	PUNCT
fnp-4366	450	1	here	here	ADV
fnp-4366	450	2	,	,	PUNCT
fnp-4366	450	3	the	the	DET
fnp-4366	450	4	number	number	NOUN
fnp-4366	450	5	of	of	ADP
fnp-4366	450	6	infected	infected	ADJ
fnp-4366	450	7	neuronal	neuronal	ADJ
fnp-4366	450	8	and	and	CCONJ
fnp-4366	450	9	glial	glial	ADJ
fnp-4366	450	10	cells	cell	NOUN
fnp-4366	450	11	outnumbered	outnumber	VERB
fnp-4366	450	12	clearly	clearly	ADV
fnp-4366	450	13	the	the	DET
fnp-4366	450	14	number	number	NOUN
fnp-4366	450	15	of	of	ADP
fnp-4366	450	16	replicating	replicate	VERB
fnp-4366	450	17	cells	cell	NOUN
fnp-4366	450	18	,	,	PUNCT
fnp-4366	450	19	suggesting	suggest	VERB
fnp-4366	450	20	a	a	DET
fnp-4366	450	21	limited	limited	ADJ
fnp-4366	450	22	viral	viral	ADJ
fnp-4366	450	23	replication	replication	NOUN
fnp-4366	450	24	(	(	PUNCT
fnp-4366	450	25	figure	figure	NOUN
fnp-4366	450	26	1b	1b	NUM
fnp-4366	450	27	)	)	PUNCT
fnp-4366	450	28	.	.	PUNCT
fnp-4366	451	1	nevertheless	nevertheless	ADV
fnp-4366	451	2	,	,	PUNCT
fnp-4366	451	3	a	a	DET
fnp-4366	451	4	pronounced	pronounce	VERB
fnp-4366	451	5	decrease	decrease	NOUN
fnp-4366	451	6	in	in	ADP
fnp-4366	451	7	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	451	8	was	be	AUX
fnp-4366	451	9	observed	observe	VERB
fnp-4366	451	10	,	,	PUNCT
fnp-4366	451	11	while	while	SCONJ
fnp-4366	451	12	no	no	DET
fnp-4366	451	13	major	major	ADJ
fnp-4366	451	14	loss	loss	NOUN
fnp-4366	451	15	of	of	ADP
fnp-4366	451	16	astrocytes	astrocyte	NOUN
fnp-4366	451	17	and	and	CCONJ
fnp-4366	451	18	neurons	neuron	NOUN
fnp-4366	451	19	was	be	AUX
fnp-4366	451	20	found	find	VERB
fnp-4366	451	21	.	.	PUNCT
fnp-4366	452	1	juxtacortical	juxtacortical	ADJ
fnp-4366	452	2	lesions	lesion	NOUN
fnp-4366	452	3	showed	show	VERB
fnp-4366	452	4	prominent	prominent	ADJ
fnp-4366	452	5	axonal	axonal	ADJ
fnp-4366	452	6	damage	damage	NOUN
fnp-4366	452	7	and	and	CCONJ
fnp-4366	452	8	loss	loss	NOUN
fnp-4366	452	9	.	.	PUNCT
fnp-4366	453	1	late	late	ADJ
fnp-4366	453	2	lesions	lesion	NOUN
fnp-4366	453	3	were	be	AUX
fnp-4366	453	4	characterized	characterize	VERB
fnp-4366	453	5	by	by	ADP
fnp-4366	453	6	a	a	DET
fnp-4366	453	7	necrotic	necrotic	ADJ
fnp-4366	453	8	-	-	PUNCT
fnp-4366	453	9	cystic	cystic	ADJ
fnp-4366	453	10	tissue	tissue	NOUN
fnp-4366	453	11	defect	defect	NOUN
fnp-4366	453	12	located	locate	VERB
fnp-4366	453	13	primarily	primarily	ADV
fnp-4366	453	14	at	at	ADP
fnp-4366	453	15	the	the	DET
fnp-4366	453	16	gray	gray	ADJ
fnp-4366	453	17	-	-	PUNCT
fnp-4366	453	18	white	white	ADJ
fnp-4366	453	19	junction	junction	NOUN
fnp-4366	453	20	and	and	CCONJ
fnp-4366	453	21	later	later	ADV
fnp-4366	453	22	spreading	spread	VERB
fnp-4366	453	23	throughout	throughout	ADP
fnp-4366	453	24	the	the	DET
fnp-4366	453	25	white	white	ADJ
fnp-4366	453	26	matter	matter	NOUN
fnp-4366	453	27	.	.	PUNCT
fnp-4366	454	1	only	only	ADV
fnp-4366	454	2	few	few	ADJ
fnp-4366	454	3	publications	publication	NOUN
fnp-4366	454	4	describe	describe	VERB
fnp-4366	454	5	jcve	jcve	NOUN
fnp-4366	454	6	as	as	ADP
fnp-4366	454	7	a	a	DET
fnp-4366	454	8	new	new	ADJ
fnp-4366	454	9	entity	entity	NOUN
fnp-4366	454	10	of	of	ADP
fnp-4366	454	11	jc	jc	PROPN
fnp-4366	454	12	virus	virus	PROPN
fnp-4366	454	13	pathologies	pathology	NOUN
fnp-4366	454	14	characterized	characterize	VERB
fnp-4366	454	15	by	by	ADP
fnp-4366	454	16	a	a	DET
fnp-4366	454	17	prominent	prominent	ADJ
fnp-4366	454	18	infection	infection	NOUN
fnp-4366	454	19	of	of	ADP
fnp-4366	454	20	neurons	neuron	NOUN
fnp-4366	454	21	.	.	PUNCT
fnp-4366	455	1	what	what	PRON
fnp-4366	455	2	distinguishes	distinguish	VERB
fnp-4366	455	3	our	our	PRON
fnp-4366	455	4	case	case	NOUN
fnp-4366	455	5	from	from	ADP
fnp-4366	455	6	others	other	NOUN
fnp-4366	455	7	is	be	AUX
fnp-4366	455	8	the	the	DET
fnp-4366	455	9	extraordinarily	extraordinarily	ADV
fnp-4366	455	10	long	long	ADJ
fnp-4366	455	11	disease	disease	NOUN
fnp-4366	455	12	course	course	NOUN
fnp-4366	455	13	without	without	ADP
fnp-4366	455	14	clear	clear	ADJ
fnp-4366	455	15	evidence	evidence	NOUN
fnp-4366	455	16	of	of	ADP
fnp-4366	455	17	immunodeficiency	immunodeficiency	NOUN
fnp-4366	455	18	.	.	PUNCT
fnp-4366	456	1	a	a	DET
fnp-4366	456	2	variant	variant	NOUN
fnp-4366	456	3	of	of	ADP
fnp-4366	456	4	unclear	unclear	ADJ
fnp-4366	456	5	significance	significance	NOUN
fnp-4366	456	6	in	in	ADP
fnp-4366	456	7	the	the	DET
fnp-4366	456	8	ifih1	ifih1	NOUN
fnp-4366	456	9	gene	gene	NOUN
fnp-4366	456	10	was	be	AUX
fnp-4366	456	11	found	find	VERB
fnp-4366	456	12	.	.	PUNCT
fnp-4366	457	1	ifih1	ifih1	VERB
fnp-4366	457	2	encodes	encode	VERB
fnp-4366	457	3	the	the	DET
fnp-4366	457	4	mda5	mda5	NOUN
fnp-4366	457	5	protein	protein	NOUN
fnp-4366	457	6	(	(	PUNCT
fnp-4366	457	7	pattern	pattern	NOUN
fnp-4366	457	8	-	-	PUNCT
fnp-4366	457	9	recognition	recognition	NOUN
fnp-4366	457	10	-	-	PUNCT
fnp-4366	457	11	receptor	receptor	NOUN
fnp-4366	457	12	)	)	PUNCT
fnp-4366	457	13	,	,	PUNCT
fnp-4366	457	14	which	which	PRON
fnp-4366	457	15	is	be	AUX
fnp-4366	457	16	part	part	NOUN
fnp-4366	457	17	of	of	ADP
fnp-4366	457	18	the	the	DET
fnp-4366	457	19	innate	innate	ADJ
fnp-4366	457	20	immune	immune	ADJ
fnp-4366	457	21	system	system	NOUN
fnp-4366	457	22	and	and	CCONJ
fnp-4366	457	23	is	be	AUX
fnp-4366	457	24	mainly	mainly	ADV
fnp-4366	457	25	responsible	responsible	ADJ
fnp-4366	457	26	for	for	ADP
fnp-4366	457	27	the	the	DET
fnp-4366	457	28	activation	activation	NOUN
fnp-4366	457	29	of	of	ADP
fnp-4366	457	30	the	the	DET
fnp-4366	457	31	antiviral	antiviral	ADJ
fnp-4366	457	32	immune	immune	ADJ
fnp-4366	457	33	response	response	NOUN
fnp-4366	457	34	such	such	ADJ
fnp-4366	457	35	as	as	ADP
fnp-4366	457	36	the	the	DET
fnp-4366	457	37	induction	induction	NOUN
fnp-4366	457	38	of	of	ADP
fnp-4366	457	39	interferon-1/-β/-α	interferon-1/-β/-α	PROPN
fnp-4366	457	40	.	.	PUNCT
fnp-4366	458	1	this	this	DET
fnp-4366	458	2	mutation	mutation	NOUN
fnp-4366	458	3	potentially	potentially	ADV
fnp-4366	458	4	predisposed	predispose	VERB
fnp-4366	458	5	to	to	ADP
fnp-4366	458	6	the	the	DET
fnp-4366	458	7	jcpyv	jcpyv	NOUN
fnp-4366	458	8	infection	infection	NOUN
fnp-4366	458	9	.	.	PUNCT
fnp-4366	459	1	the	the	DET
fnp-4366	459	2	slow	slow	ADJ
fnp-4366	459	3	disease	disease	NOUN
fnp-4366	459	4	progression	progression	NOUN
fnp-4366	459	5	in	in	ADP
fnp-4366	459	6	our	our	PRON
fnp-4366	459	7	patient	patient	NOUN
fnp-4366	459	8	is	be	AUX
fnp-4366	459	9	possibly	possibly	ADV
fnp-4366	459	10	due	due	ADJ
fnp-4366	459	11	to	to	ADP
fnp-4366	459	12	relatively	relatively	ADV
fnp-4366	459	13	well	well	ADV
fnp-4366	459	14	-	-	PUNCT
fnp-4366	459	15	preserved	preserve	VERB
fnp-4366	459	16	immune	immune	ADJ
fnp-4366	459	17	function	function	NOUN
fnp-4366	459	18	.	.	PUNCT
fnp-4366	460	1	the	the	DET
fnp-4366	460	2	presence	presence	NOUN
fnp-4366	460	3	of	of	ADP
fnp-4366	460	4	a	a	DET
fnp-4366	460	5	stable	stable	ADJ
fnp-4366	460	6	,	,	PUNCT
fnp-4366	460	7	archetype	archetype	NOUN
fnp-4366	460	8	variant	variant	NOUN
fnp-4366	460	9	could	could	AUX
fnp-4366	460	10	also	also	ADV
fnp-4366	460	11	indicate	indicate	VERB
fnp-4366	460	12	a	a	DET
fnp-4366	460	13	less	less	ADV
fnp-4366	460	14	productive	productive	ADJ
fnp-4366	460	15	viral	viral	ADJ
fnp-4366	460	16	variant	variant	NOUN
fnp-4366	460	17	.	.	PUNCT
fnp-4366	461	1	our	our	PRON
fnp-4366	461	2	detailed	detailed	ADJ
fnp-4366	461	3	histological	histological	ADJ
fnp-4366	461	4	description	description	NOUN
fnp-4366	461	5	shows	show	VERB
fnp-4366	461	6	that	that	SCONJ
fnp-4366	461	7	infected	infected	ADJ
fnp-4366	461	8	cells	cell	NOUN
fnp-4366	461	9	clearly	clearly	ADV
fnp-4366	461	10	outnumbered	outnumber	VERB
fnp-4366	461	11	replicating	replicate	VERB
fnp-4366	461	12	cells	cell	NOUN
fnp-4366	461	13	,	,	PUNCT
fnp-4366	461	14	leading	lead	VERB
fnp-4366	461	15	to	to	ADP
fnp-4366	461	16	production	production	NOUN
fnp-4366	461	17	of	of	ADP
fnp-4366	461	18	virus	virus	NOUN
fnp-4366	461	19	in	in	ADP
fnp-4366	461	20	only	only	ADJ
fnp-4366	461	21	single	single	ADJ
fnp-4366	461	22	cells	cell	NOUN
fnp-4366	461	23	.	.	PUNCT
fnp-4366	462	1	despite	despite	SCONJ
fnp-4366	462	2	numerous	numerous	ADJ
fnp-4366	462	3	infected	infected	ADJ
fnp-4366	462	4	neurons	neuron	NOUN
fnp-4366	462	5	,	,	PUNCT
fnp-4366	462	6	in	in	ADP
fnp-4366	462	7	the	the	DET
fnp-4366	462	8	long	long	ADJ
fnp-4366	462	9	run	run	NOUN
fnp-4366	462	10	white	white	ADJ
fnp-4366	462	11	matter	matter	NOUN
fnp-4366	462	12	lesions	lesion	NOUN
fnp-4366	462	13	with	with	ADP
fnp-4366	462	14	a	a	DET
fnp-4366	462	15	pronounced	pronounced	ADJ
fnp-4366	462	16	tissue	tissue	NOUN
fnp-4366	462	17	destruction	destruction	NOUN
fnp-4366	462	18	prevailed	prevail	VERB
fnp-4366	462	19	.	.	PUNCT
fnp-4366	463	1	thus	thus	ADV
fnp-4366	463	2	,	,	PUNCT
fnp-4366	463	3	destructive	destructive	ADJ
fnp-4366	463	4	white	white	ADJ
fnp-4366	463	5	matter	matter	NOUN
fnp-4366	463	6	lesions	lesion	NOUN
fnp-4366	463	7	seem	seem	VERB
fnp-4366	463	8	to	to	PART
fnp-4366	463	9	be	be	AUX
fnp-4366	463	10	a	a	DET
fnp-4366	463	11	pivotal	pivotal	ADJ
fnp-4366	463	12	histopathological	histopathological	ADJ
fnp-4366	463	13	characteristic	characteristic	NOUN
fnp-4366	463	14	of	of	ADP
fnp-4366	463	15	jcve	jcve	PROPN
fnp-4366	463	16	.	.	PUNCT
fnp-4366	464	1	figure	figure	VERB
fnp-4366	464	2	1	1	NUM
fnp-4366	464	3	:	:	PUNCT
fnp-4366	464	4	(	(	PUNCT
fnp-4366	464	5	a	a	X
fnp-4366	464	6	)	)	PUNCT
fnp-4366	464	7	cortex	cortex	NOUN
fnp-4366	464	8	with	with	ADP
fnp-4366	464	9	juxtacortical	juxtacortical	ADJ
fnp-4366	464	10	lesion	lesion	NOUN
fnp-4366	464	11	(	(	PUNCT
fnp-4366	464	12	arrow	arrow	NOUN
fnp-4366	464	13	)	)	PUNCT
fnp-4366	464	14	and	and	CCONJ
fnp-4366	464	15	massive	massive	ADJ
fnp-4366	464	16	cystic	cystic	ADJ
fnp-4366	464	17	changes	change	NOUN
fnp-4366	464	18	within	within	ADP
fnp-4366	464	19	the	the	DET
fnp-4366	464	20	white	white	ADJ
fnp-4366	464	21	matter	matter	NOUN
fnp-4366	464	22	(	(	PUNCT
fnp-4366	464	23	wm	wm	PROPN
fnp-4366	464	24	)	)	PUNCT
fnp-4366	464	25	.	.	PUNCT
fnp-4366	465	1	(	(	PUNCT
fnp-4366	465	2	b	b	X
fnp-4366	465	3	)	)	PUNCT
fnp-4366	465	4	multiple	multiple	ADJ
fnp-4366	465	5	infected	infect	VERB
fnp-4366	465	6	cortical	cortical	ADJ
fnp-4366	465	7	pyramidal	pyramidal	ADJ
fnp-4366	465	8	neurons	neuron	NOUN
fnp-4366	465	9	(	(	PUNCT
fnp-4366	465	10	t	t	PROPN
fnp-4366	465	11	-	-	PUNCT
fnp-4366	465	12	ag	ag	NOUN
fnp-4366	465	13	=	=	PROPN
fnp-4366	465	14	early	early	ADJ
fnp-4366	465	15	viral	viral	ADJ
fnp-4366	465	16	protein	protein	NOUN
fnp-4366	465	17	,	,	PUNCT
fnp-4366	465	18	indicating	indicate	VERB
fnp-4366	465	19	infection	infection	NOUN
fnp-4366	465	20	,	,	PUNCT
fnp-4366	465	21	neun	neun	NOUN
fnp-4366	465	22	=	=	SYM
fnp-4366	465	23	neuronal	neuronal	ADJ
fnp-4366	465	24	marker	marker	NOUN
fnp-4366	465	25	)	)	PUNCT
fnp-4366	465	26	.	.	PUNCT
fnp-4366	465	27	  	  	SPACE
fnp-4366	466	1	4.02	4.02	NUM
fnp-4366	466	2	free	free	ADJ
fnp-4366	466	3	neuropathol	neuropathol	NOUN
fnp-4366	466	4	3:20:46	3:20:46	NUM
fnp-4366	466	5	reduction	reduction	NOUN
fnp-4366	466	6	of	of	ADP
fnp-4366	466	7	oligodendrocyte	oligodendrocyte	ADJ
fnp-4366	466	8	populations	population	NOUN
fnp-4366	466	9	in	in	ADP
fnp-4366	466	10	patients	patient	NOUN
fnp-4366	466	11	with	with	ADP
fnp-4366	466	12	late	late	ADJ
fnp-4366	466	13	-	-	PUNCT
fnp-4366	466	14	onset	onset	VERB
fnp-4366	466	15	multiple	multiple	ADJ
fnp-4366	466	16	sclerosis	sclerosis	NOUN
fnp-4366	466	17	schirin	schirin	NOUN
fnp-4366	466	18	stephan1	stephan1	NOUN
fnp-4366	466	19	,	,	PUNCT
fnp-4366	466	20	lidia	lidia	PROPN
fnp-4366	466	21	stork1	stork1	PROPN
fnp-4366	466	22	,	,	PUNCT
fnp-4366	466	23	wolfgang	wolfgang	PROPN
fnp-4366	466	24	brück1	brück1	PROPN
fnp-4366	466	25	,	,	PUNCT
fnp-4366	466	26	christine	christine	PROPN
fnp-4366	466	27	stadelmann	stadelmann	PROPN
fnp-4366	466	28	-	-	PUNCT
fnp-4366	466	29	nessler1	nessler1	NOUN
fnp-4366	466	30	,	,	PUNCT
fnp-4366	466	31	imke	imke	PROPN
fnp-4366	466	32	metz1	metz1	NOUN
fnp-4366	466	33	1	1	NUM
fnp-4366	466	34	university	university	NOUN
fnp-4366	466	35	medical	medical	ADJ
fnp-4366	466	36	center	center	NOUN
fnp-4366	466	37	göttingen	göttingen	NOUN
fnp-4366	466	38	,	,	PUNCT
fnp-4366	466	39	institute	institute	NOUN
fnp-4366	466	40	of	of	ADP
fnp-4366	466	41	neuropathology	neuropathology	NOUN
fnp-4366	466	42	,	,	PUNCT
fnp-4366	466	43	göttingen	göttingen	NOUN
fnp-4366	466	44	,	,	PUNCT
fnp-4366	466	45	deutschland	deutschland	NOUN
fnp-4366	466	46	background	background	NOUN
fnp-4366	466	47	:	:	PUNCT
fnp-4366	466	48	over	over	ADP
fnp-4366	466	49	2.8	2.8	NUM
fnp-4366	466	50	million	million	NUM
fnp-4366	466	51	people	people	NOUN
fnp-4366	466	52	worldwide	worldwide	ADV
fnp-4366	466	53	suffer	suffer	VERB
fnp-4366	466	54	from	from	ADP
fnp-4366	466	55	multiple	multiple	ADJ
fnp-4366	466	56	sclerosis	sclerosis	NOUN
fnp-4366	466	57	(	(	PUNCT
fnp-4366	466	58	ms	ms	PROPN
fnp-4366	466	59	)	)	PUNCT
fnp-4366	466	60	a	a	DET
fnp-4366	466	61	chronic	chronic	ADJ
fnp-4366	466	62	inflammatory	inflammatory	ADJ
fnp-4366	466	63	demyelinating	demyelinate	VERB
fnp-4366	466	64	disease	disease	NOUN
fnp-4366	466	65	of	of	ADP
fnp-4366	466	66	the	the	DET
fnp-4366	466	67	cns	cns	NOUN
fnp-4366	466	68	.	.	PUNCT
fnp-4366	467	1	typical	typical	ADJ
fnp-4366	467	2	or	or	CCONJ
fnp-4366	467	3	normal	normal	ADJ
fnp-4366	467	4	-	-	PUNCT
fnp-4366	467	5	onset	onset	NOUN
fnp-4366	467	6	ms	ms	NOUN
fnp-4366	467	7	(	(	PUNCT
fnp-4366	467	8	noms	nom	NOUN
fnp-4366	467	9	)	)	PUNCT
fnp-4366	467	10	manifests	manifest	NOUN
fnp-4366	467	11	in	in	ADP
fnp-4366	467	12	young	young	ADJ
fnp-4366	467	13	adults	adult	NOUN
fnp-4366	467	14	(	(	PUNCT
fnp-4366	467	15	20	20	NUM
fnp-4366	467	16	-	-	SYM
fnp-4366	467	17	40	40	NUM
fnp-4366	467	18	years	year	NOUN
fnp-4366	467	19	old	old	ADJ
fnp-4366	467	20	)	)	PUNCT
fnp-4366	467	21	.	.	PUNCT
fnp-4366	468	1	in	in	ADP
fnp-4366	468	2	3	3	NUM
fnp-4366	468	3	-	-	SYM
fnp-4366	468	4	12	12	NUM
fnp-4366	468	5	%	%	NOUN
fnp-4366	468	6	of	of	ADP
fnp-4366	468	7	cases	case	NOUN
fnp-4366	468	8	,	,	PUNCT
fnp-4366	468	9	the	the	DET
fnp-4366	468	10	disease	disease	NOUN
fnp-4366	468	11	begins	begin	VERB
fnp-4366	468	12	in	in	ADP
fnp-4366	468	13	elderly	elderly	ADJ
fnp-4366	468	14	patients	patient	NOUN
fnp-4366	468	15	>	>	PUNCT
fnp-4366	468	16	50	50	NUM
fnp-4366	468	17	years	year	NOUN
fnp-4366	468	18	of	of	ADP
fnp-4366	468	19	age	age	NOUN
fnp-4366	468	20	(	(	PUNCT
fnp-4366	468	21	late	late	ADJ
fnp-4366	468	22	-	-	PUNCT
fnp-4366	468	23	onset	onset	NOUN
fnp-4366	468	24	ms	ms	NOUN
fnp-4366	468	25	or	or	CCONJ
fnp-4366	468	26	loms	lom	NOUN
fnp-4366	468	27	)	)	PUNCT
fnp-4366	468	28	.	.	PUNCT
fnp-4366	469	1	such	such	ADJ
fnp-4366	469	2	patients	patient	NOUN
fnp-4366	469	3	more	more	ADV
fnp-4366	469	4	often	often	ADV
fnp-4366	469	5	suffer	suffer	VERB
fnp-4366	469	6	from	from	ADP
fnp-4366	469	7	primary	primary	ADJ
fnp-4366	469	8	progressive	progressive	ADJ
fnp-4366	469	9	ms	ms	PROPN
fnp-4366	469	10	,	,	PUNCT
fnp-4366	469	11	faster	fast	ADJ
fnp-4366	469	12	disease	disease	NOUN
fnp-4366	469	13	progression	progression	NOUN
fnp-4366	469	14	,	,	PUNCT
fnp-4366	469	15	and	and	CCONJ
fnp-4366	469	16	worse	bad	ADJ
fnp-4366	469	17	recovery	recovery	NOUN
fnp-4366	469	18	from	from	ADP
fnp-4366	469	19	relapses	relapse	NOUN
fnp-4366	469	20	,	,	PUNCT
fnp-4366	469	21	as	as	ADV
fnp-4366	469	22	well	well	ADV
fnp-4366	469	23	as	as	ADP
fnp-4366	469	24	age	age	NOUN
fnp-4366	469	25	-	-	PUNCT
fnp-4366	469	26	related	relate	VERB
fnp-4366	469	27	comorbidities	comorbiditie	NOUN
fnp-4366	469	28	.	.	PUNCT
fnp-4366	470	1	animal	animal	NOUN
fnp-4366	470	2	studies	study	NOUN
fnp-4366	470	3	suggest	suggest	VERB
fnp-4366	470	4	a	a	DET
fnp-4366	470	5	less	less	ADV
fnp-4366	470	6	efficient	efficient	ADJ
fnp-4366	470	7	remyelination	remyelination	NOUN
fnp-4366	470	8	in	in	ADP
fnp-4366	470	9	elderly	elderly	ADJ
fnp-4366	470	10	animals	animal	NOUN
fnp-4366	470	11	.	.	PUNCT
fnp-4366	471	1	marked	mark	VERB
fnp-4366	471	2	remyelination	remyelination	NOUN
fnp-4366	471	3	,	,	PUNCT
fnp-4366	471	4	which	which	PRON
fnp-4366	471	5	is	be	AUX
fnp-4366	471	6	observed	observe	VERB
fnp-4366	471	7	in	in	ADP
fnp-4366	471	8	23	23	NUM
fnp-4366	471	9	-	-	SYM
fnp-4366	471	10	50	50	NUM
fnp-4366	471	11	%	%	NOUN
fnp-4366	471	12	of	of	ADP
fnp-4366	471	13	ms	ms	NOUN
fnp-4366	471	14	lesions	lesion	NOUN
fnp-4366	471	15	in	in	ADP
fnp-4366	471	16	young	young	ADJ
fnp-4366	471	17	adult	adult	NOUN
fnp-4366	471	18	-	-	PUNCT
fnp-4366	471	19	onset	onset	NOUN
fnp-4366	471	20	patients	patient	NOUN
fnp-4366	471	21	,	,	PUNCT
fnp-4366	471	22	could	could	AUX
fnp-4366	471	23	be	be	AUX
fnp-4366	471	24	slower	slow	ADJ
fnp-4366	471	25	and	and	CCONJ
fnp-4366	471	26	less	less	ADV
fnp-4366	471	27	successful	successful	ADJ
fnp-4366	471	28	in	in	ADP
fnp-4366	471	29	loms	lom	NOUN
fnp-4366	471	30	.	.	PUNCT
fnp-4366	472	1	a	a	DET
fnp-4366	472	2	recent	recent	ADJ
fnp-4366	472	3	study	study	NOUN
fnp-4366	472	4	showed	show	VERB
fnp-4366	472	5	that	that	SCONJ
fnp-4366	472	6	cells	cell	NOUN
fnp-4366	472	7	expressing	express	VERB
fnp-4366	472	8	bcas1	bcas1	NOUN
fnp-4366	472	9	represent	represent	VERB
fnp-4366	472	10	a	a	DET
fnp-4366	472	11	subpopulation	subpopulation	NOUN
fnp-4366	472	12	of	of	ADP
fnp-4366	472	13	actively	actively	ADV
fnp-4366	472	14	myelinating	myelinate	VERB
fnp-4366	472	15	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	472	16	,	,	PUNCT
fnp-4366	472	17	and	and	CCONJ
fnp-4366	472	18	can	can	AUX
fnp-4366	472	19	serve	serve	VERB
fnp-4366	472	20	as	as	ADP
fnp-4366	472	21	a	a	DET
fnp-4366	472	22	reliable	reliable	ADJ
fnp-4366	472	23	marker	marker	NOUN
fnp-4366	472	24	of	of	ADP
fnp-4366	472	25	ongoing	ongoing	ADJ
fnp-4366	472	26	remyelination	remyelination	NOUN
fnp-4366	472	27	.	.	PUNCT
fnp-4366	473	1	questions	question	NOUN
fnp-4366	473	2	:	:	PUNCT
fnp-4366	473	3	we	we	PRON
fnp-4366	473	4	addressed	address	VERB
fnp-4366	473	5	the	the	DET
fnp-4366	473	6	question	question	NOUN
fnp-4366	473	7	,	,	PUNCT
fnp-4366	473	8	if	if	SCONJ
fnp-4366	473	9	myelin	myelin	NOUN
fnp-4366	473	10	regeneration	regeneration	NOUN
fnp-4366	473	11	in	in	ADP
fnp-4366	473	12	loms	lom	NOUN
fnp-4366	473	13	patients	patient	NOUN
fnp-4366	473	14	is	be	AUX
fnp-4366	473	15	less	less	ADV
fnp-4366	473	16	effective	effective	ADJ
fnp-4366	473	17	.	.	PUNCT
fnp-4366	474	1	methods	method	NOUN
fnp-4366	474	2	:	:	PUNCT
fnp-4366	474	3	we	we	PRON
fnp-4366	474	4	performed	perform	VERB
fnp-4366	474	5	histological	histological	ADJ
fnp-4366	474	6	analyses	analysis	NOUN
fnp-4366	474	7	of	of	ADP
fnp-4366	474	8	three	three	NUM
fnp-4366	474	9	oligodendrocyte	oligodendrocyte	ADJ
fnp-4366	474	10	markers	marker	NOUN
fnp-4366	474	11	that	that	PRON
fnp-4366	474	12	correspond	correspond	VERB
fnp-4366	474	13	to	to	ADP
fnp-4366	474	14	different	different	ADJ
fnp-4366	474	15	oligodendrocyte	oligodendrocyte	ADJ
fnp-4366	474	16	maturation	maturation	NOUN
fnp-4366	474	17	stages	stage	NOUN
fnp-4366	474	18	(	(	PUNCT
fnp-4366	474	19	olig2	olig2	NOUN
fnp-4366	474	20	positive	positive	ADJ
fnp-4366	474	21	cells	cell	NOUN
fnp-4366	474	22	with	with	ADP
fnp-4366	474	23	a	a	DET
fnp-4366	474	24	strong	strong	ADJ
fnp-4366	474	25	nuclear	nuclear	ADJ
fnp-4366	474	26	signal	signal	NOUN
fnp-4366	474	27	for	for	ADP
fnp-4366	474	28	oligodendrocyte	oligodendrocyte	ADJ
fnp-4366	474	29	precursor	precursor	NOUN
fnp-4366	474	30	cells	cell	NOUN
fnp-4366	474	31	,	,	PUNCT
fnp-4366	474	32	bcas1	bcas1	NOUN
fnp-4366	474	33	for	for	ADP
fnp-4366	474	34	myelinating	myelinate	VERB
fnp-4366	474	35	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	474	36	,	,	PUNCT
fnp-4366	474	37	and	and	CCONJ
fnp-4366	474	38	nogoa	nogoa	ADJ
fnp-4366	474	39	for	for	ADP
fnp-4366	474	40	mature	mature	ADJ
fnp-4366	474	41	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	474	42	)	)	PUNCT
fnp-4366	474	43	in	in	ADP
fnp-4366	474	44	biopsy	biopsy	NOUN
fnp-4366	474	45	specimens	specimen	NOUN
fnp-4366	474	46	from	from	ADP
fnp-4366	474	47	loms	lom	NOUN
fnp-4366	474	48	patients	patient	NOUN
fnp-4366	474	49	(	(	PUNCT
fnp-4366	474	50	n=30	n=30	NOUN
fnp-4366	474	51	)	)	PUNCT
fnp-4366	474	52	,	,	PUNCT
fnp-4366	474	53	and	and	CCONJ
fnp-4366	474	54	compared	compare	VERB
fnp-4366	474	55	them	they	PRON
fnp-4366	474	56	with	with	ADP
fnp-4366	474	57	noms	nom	NOUN
fnp-4366	474	58	patients	patient	NOUN
fnp-4366	474	59	(	(	PUNCT
fnp-4366	474	60	n=25	n=25	ADV
fnp-4366	474	61	)	)	PUNCT
fnp-4366	474	62	.	.	PUNCT
fnp-4366	475	1	results	result	NOUN
fnp-4366	475	2	:	:	PUNCT
fnp-4366	475	3	the	the	DET
fnp-4366	475	4	number	number	NOUN
fnp-4366	475	5	of	of	ADP
fnp-4366	475	6	mature	mature	ADJ
fnp-4366	475	7	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	475	8	was	be	AUX
fnp-4366	475	9	significantly	significantly	ADV
fnp-4366	475	10	lower	low	ADJ
fnp-4366	475	11	in	in	ADP
fnp-4366	475	12	the	the	DET
fnp-4366	475	13	normal	normal	ADJ
fnp-4366	475	14	appearing	appearing	NOUN
fnp-4366	475	15	(	(	PUNCT
fnp-4366	475	16	non	non	ADJ
fnp-4366	475	17	-	-	ADJ
fnp-4366	475	18	demyelinated	demyelinated	ADJ
fnp-4366	475	19	)	)	PUNCT
fnp-4366	475	20	(	(	PUNCT
fnp-4366	475	21	p=0.02	p=0.02	NOUN
fnp-4366	475	22	)	)	PUNCT
fnp-4366	475	23	and	and	CCONJ
fnp-4366	475	24	perilesional	perilesional	ADJ
fnp-4366	475	25	white	white	ADJ
fnp-4366	475	26	matter	matter	NOUN
fnp-4366	475	27	(	(	PUNCT
fnp-4366	475	28	p<0.0001	p<0.0001	NOUN
fnp-4366	475	29	)	)	PUNCT
fnp-4366	475	30	in	in	ADP
fnp-4366	475	31	patients	patient	NOUN
fnp-4366	475	32	with	with	ADP
fnp-4366	475	33	loms	lom	NOUN
fnp-4366	475	34	compared	compare	VERB
fnp-4366	475	35	to	to	ADP
fnp-4366	475	36	noms	nom	NOUN
fnp-4366	475	37	.	.	PUNCT
fnp-4366	476	1	moreover	moreover	ADV
fnp-4366	476	2	,	,	PUNCT
fnp-4366	476	3	mature	mature	ADJ
fnp-4366	476	4	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	476	5	in	in	ADP
fnp-4366	476	6	these	these	DET
fnp-4366	476	7	regions	region	NOUN
fnp-4366	476	8	showed	show	VERB
fnp-4366	476	9	a	a	DET
fnp-4366	476	10	negative	negative	ADJ
fnp-4366	476	11	correlation	correlation	NOUN
fnp-4366	476	12	with	with	ADP
fnp-4366	476	13	the	the	DET
fnp-4366	476	14	age	age	NOUN
fnp-4366	476	15	of	of	ADP
fnp-4366	476	16	patients	patient	NOUN
fnp-4366	476	17	(	(	PUNCT
fnp-4366	476	18	r=-0.5	r=-0.5	NOUN
fnp-4366	476	19	,	,	PUNCT
fnp-4366	476	20	p=0.01	p=0.01	NUM
fnp-4366	476	21	)	)	PUNCT
fnp-4366	476	22	.	.	PUNCT
fnp-4366	477	1	there	there	PRON
fnp-4366	477	2	were	be	VERB
fnp-4366	477	3	no	no	DET
fnp-4366	477	4	differences	difference	NOUN
fnp-4366	477	5	in	in	ADP
fnp-4366	477	6	the	the	DET
fnp-4366	477	7	number	number	NOUN
fnp-4366	477	8	of	of	ADP
fnp-4366	477	9	oligodendrocyte	oligodendrocyte	ADJ
fnp-4366	477	10	precursor	precursor	NOUN
fnp-4366	477	11	cells	cell	NOUN
fnp-4366	477	12	between	between	ADP
fnp-4366	477	13	the	the	DET
fnp-4366	477	14	two	two	NUM
fnp-4366	477	15	groups	group	NOUN
fnp-4366	477	16	.	.	PUNCT
fnp-4366	478	1	also	also	ADV
fnp-4366	478	2	,	,	PUNCT
fnp-4366	478	3	the	the	DET
fnp-4366	478	4	population	population	NOUN
fnp-4366	478	5	of	of	ADP
fnp-4366	478	6	active	active	ADJ
fnp-4366	478	7	myelinating	myelinate	VERB
fnp-4366	478	8	bcas1	bcas1	NOUN
fnp-4366	478	9	+	+	SYM
fnp-4366	478	10	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	478	11	was	be	AUX
fnp-4366	478	12	significantly	significantly	ADV
fnp-4366	478	13	lower	low	ADJ
fnp-4366	478	14	in	in	ADP
fnp-4366	478	15	loms	lom	NOUN
fnp-4366	478	16	compared	compare	VERB
fnp-4366	478	17	to	to	ADP
fnp-4366	478	18	noms	nom	NOUN
fnp-4366	478	19	patients	patient	NOUN
fnp-4366	478	20	in	in	ADP
fnp-4366	478	21	the	the	DET
fnp-4366	478	22	normal	normal	ADV
fnp-4366	478	23	-	-	PUNCT
fnp-4366	478	24	appearing	appear	VERB
fnp-4366	478	25	white	white	ADJ
fnp-4366	478	26	matter	matter	NOUN
fnp-4366	478	27	(	(	PUNCT
fnp-4366	478	28	p=0.03	p=0.03	ADJ
fnp-4366	478	29	)	)	PUNCT
fnp-4366	478	30	.	.	PUNCT
fnp-4366	479	1	again	again	ADV
fnp-4366	479	2	,	,	PUNCT
fnp-4366	479	3	the	the	DET
fnp-4366	479	4	number	number	NOUN
fnp-4366	479	5	of	of	ADP
fnp-4366	479	6	myelinating	myelinate	VERB
fnp-4366	479	7	cells	cell	NOUN
fnp-4366	479	8	correlated	correlate	VERB
fnp-4366	479	9	negatively	negatively	ADV
fnp-4366	479	10	with	with	ADP
fnp-4366	479	11	the	the	DET
fnp-4366	479	12	age	age	NOUN
fnp-4366	479	13	of	of	ADP
fnp-4366	479	14	patients	patient	NOUN
fnp-4366	479	15	(	(	PUNCT
fnp-4366	479	16	r=-0.5	r=-0.5	NOUN
fnp-4366	479	17	,	,	PUNCT
fnp-4366	479	18	p=0.01	p=0.01	NUM
fnp-4366	479	19	)	)	PUNCT
fnp-4366	479	20	.	.	PUNCT
fnp-4366	480	1	in	in	ADP
fnp-4366	480	2	both	both	DET
fnp-4366	480	3	groups	group	NOUN
fnp-4366	480	4	,	,	PUNCT
fnp-4366	480	5	the	the	DET
fnp-4366	480	6	highest	high	ADJ
fnp-4366	480	7	number	number	NOUN
fnp-4366	480	8	of	of	ADP
fnp-4366	480	9	active	active	ADJ
fnp-4366	480	10	myelinating	myelinate	VERB
fnp-4366	480	11	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	480	12	was	be	AUX
fnp-4366	480	13	found	find	VERB
fnp-4366	480	14	in	in	ADP
fnp-4366	480	15	early	early	ADJ
fnp-4366	480	16	active	active	ADJ
fnp-4366	480	17	demyelinating	demyelinate	VERB
fnp-4366	480	18	lesions	lesion	NOUN
fnp-4366	480	19	and	and	CCONJ
fnp-4366	480	20	here	here	ADV
fnp-4366	480	21	at	at	ADP
fnp-4366	480	22	the	the	DET
fnp-4366	480	23	lesion	lesion	NOUN
fnp-4366	480	24	edge	edge	NOUN
fnp-4366	480	25	.	.	PUNCT
fnp-4366	481	1	although	although	SCONJ
fnp-4366	481	2	no	no	DET
fnp-4366	481	3	significant	significant	ADJ
fnp-4366	481	4	differences	difference	NOUN
fnp-4366	481	5	in	in	ADP
fnp-4366	481	6	the	the	DET
fnp-4366	481	7	number	number	NOUN
fnp-4366	481	8	of	of	ADP
fnp-4366	481	9	active	active	ADJ
fnp-4366	481	10	myelinating	myelinating	ADJ
fnp-4366	481	11	cells	cell	NOUN
fnp-4366	481	12	was	be	AUX
fnp-4366	481	13	found	find	VERB
fnp-4366	481	14	in	in	ADP
fnp-4366	481	15	lesion	lesion	NOUN
fnp-4366	481	16	areas	area	NOUN
fnp-4366	481	17	comparing	compare	VERB
fnp-4366	481	18	loms	lom	NOUN
fnp-4366	481	19	and	and	CCONJ
fnp-4366	481	20	noms	nom	NOUN
fnp-4366	481	21	,	,	PUNCT
fnp-4366	481	22	a	a	DET
fnp-4366	481	23	trend	trend	NOUN
fnp-4366	481	24	for	for	ADP
fnp-4366	481	25	higher	high	ADJ
fnp-4366	481	26	numbers	number	NOUN
fnp-4366	481	27	of	of	ADP
fnp-4366	481	28	myelinating	myelinate	VERB
fnp-4366	481	29	cells	cell	NOUN
fnp-4366	481	30	was	be	AUX
fnp-4366	481	31	observed	observe	VERB
fnp-4366	481	32	in	in	ADP
fnp-4366	481	33	the	the	DET
fnp-4366	481	34	center	center	NOUN
fnp-4366	481	35	of	of	ADP
fnp-4366	481	36	late	late	ADJ
fnp-4366	481	37	active	active	ADJ
fnp-4366	481	38	lesions	lesion	NOUN
fnp-4366	481	39	in	in	ADP
fnp-4366	481	40	noms	nom	NOUN
fnp-4366	481	41	.	.	PUNCT
fnp-4366	482	1	in	in	ADP
fnp-4366	482	2	general	general	ADJ
fnp-4366	482	3	,	,	PUNCT
fnp-4366	482	4	older	old	ADJ
fnp-4366	482	5	lesions	lesion	NOUN
fnp-4366	482	6	(	(	PUNCT
fnp-4366	482	7	late	late	ADV
fnp-4366	482	8	active	active	ADJ
fnp-4366	482	9	demyelinating	demyelinating	ADJ
fnp-4366	482	10	and	and	CCONJ
fnp-4366	482	11	inactive	inactive	ADJ
fnp-4366	482	12	lesions	lesion	NOUN
fnp-4366	482	13	)	)	PUNCT
fnp-4366	482	14	showed	show	VERB
fnp-4366	482	15	lower	low	ADJ
fnp-4366	482	16	numbers	number	NOUN
fnp-4366	482	17	of	of	ADP
fnp-4366	482	18	active	active	ADJ
fnp-4366	482	19	myelinating	myelinating	ADJ
fnp-4366	482	20	cells	cell	NOUN
fnp-4366	482	21	.	.	PUNCT
fnp-4366	483	1	loms	lom	NOUN
fnp-4366	483	2	patients	patient	NOUN
fnp-4366	483	3	had	have	VERB
fnp-4366	483	4	a	a	DET
fnp-4366	483	5	significantly	significantly	ADV
fnp-4366	483	6	higher	high	ADJ
fnp-4366	483	7	edss	edss	ADJ
fnp-4366	483	8	score	score	NOUN
fnp-4366	483	9	(	(	PUNCT
fnp-4366	483	10	median	median	NOUN
fnp-4366	483	11	3.5	3.5	NUM
fnp-4366	483	12	,	,	PUNCT
fnp-4366	483	13	p=0.003	p=0.003	NOUN
fnp-4366	483	14	)	)	PUNCT
fnp-4366	483	15	at	at	ADP
fnp-4366	483	16	last	last	ADJ
fnp-4366	483	17	follow	follow	NOUN
fnp-4366	483	18	-	-	PUNCT
fnp-4366	483	19	up	up	NOUN
fnp-4366	483	20	as	as	SCONJ
fnp-4366	483	21	compared	compare	VERB
fnp-4366	483	22	to	to	ADP
fnp-4366	483	23	noms	nom	NOUN
fnp-4366	483	24	patients	patient	NOUN
fnp-4366	483	25	(	(	PUNCT
fnp-4366	483	26	median	median	NOUN
fnp-4366	483	27	2.0	2.0	NUM
fnp-4366	483	28	)	)	PUNCT
fnp-4366	483	29	.	.	PUNCT
fnp-4366	484	1	a	a	DET
fnp-4366	484	2	higher	high	ADJ
fnp-4366	484	3	edss	edss	ADJ
fnp-4366	484	4	score	score	NOUN
fnp-4366	484	5	was	be	AUX
fnp-4366	484	6	associated	associate	VERB
fnp-4366	484	7	with	with	ADP
fnp-4366	484	8	a	a	DET
fnp-4366	484	9	lower	low	ADJ
fnp-4366	484	10	number	number	NOUN
fnp-4366	484	11	of	of	ADP
fnp-4366	484	12	both	both	CCONJ
fnp-4366	484	13	mature	mature	ADJ
fnp-4366	484	14	and	and	CCONJ
fnp-4366	484	15	oligodendrocyte	oligodendrocyte	ADJ
fnp-4366	484	16	precursor	precursor	NOUN
fnp-4366	484	17	cells	cell	NOUN
fnp-4366	484	18	in	in	ADP
fnp-4366	484	19	active	active	ADJ
fnp-4366	484	20	ms	ms	NOUN
fnp-4366	484	21	lesions	lesion	NOUN
fnp-4366	484	22	(	(	PUNCT
fnp-4366	484	23	r=-0.42	r=-0.42	NOUN
fnp-4366	484	24	,	,	PUNCT
fnp-4366	484	25	p=0.01	p=0.01	NOUN
fnp-4366	484	26	and	and	CCONJ
fnp-4366	484	27	r=-0.54	r=-0.54	NUM
fnp-4366	484	28	,	,	PUNCT
fnp-4366	484	29	p=0.002	p=0.002	X
fnp-4366	484	30	respectively	respectively	ADV
fnp-4366	484	31	)	)	PUNCT
fnp-4366	484	32	.	.	PUNCT
fnp-4366	485	1	conclusions	conclusion	NOUN
fnp-4366	485	2	:	:	PUNCT
fnp-4366	486	1	we	we	PRON
fnp-4366	486	2	observed	observe	VERB
fnp-4366	486	3	a	a	DET
fnp-4366	486	4	significant	significant	ADJ
fnp-4366	486	5	reduction	reduction	NOUN
fnp-4366	486	6	of	of	ADP
fnp-4366	486	7	active	active	ADJ
fnp-4366	486	8	myelinating	myelinating	NOUN
fnp-4366	486	9	and	and	CCONJ
fnp-4366	486	10	mature	mature	ADJ
fnp-4366	486	11	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	486	12	in	in	ADP
fnp-4366	486	13	the	the	DET
fnp-4366	486	14	periplaque	periplaque	NOUN
fnp-4366	486	15	and	and	CCONJ
fnp-4366	486	16	normal	normal	ADJ
fnp-4366	486	17	appearing	appear	VERB
fnp-4366	486	18	white	white	ADJ
fnp-4366	486	19	matter	matter	NOUN
fnp-4366	486	20	of	of	ADP
fnp-4366	486	21	loms	lom	NOUN
fnp-4366	486	22	patients	patient	NOUN
fnp-4366	486	23	.	.	PUNCT
fnp-4366	487	1	this	this	PRON
fnp-4366	487	2	may	may	AUX
fnp-4366	487	3	result	result	VERB
fnp-4366	487	4	in	in	ADP
fnp-4366	487	5	a	a	DET
fnp-4366	487	6	lower	low	ADJ
fnp-4366	487	7	remyelination	remyelination	NOUN
fnp-4366	487	8	within	within	ADP
fnp-4366	487	9	lesions	lesion	NOUN
fnp-4366	487	10	.	.	PUNCT
fnp-4366	488	1	our	our	PRON
fnp-4366	488	2	results	result	NOUN
fnp-4366	488	3	suggest	suggest	VERB
fnp-4366	488	4	a	a	DET
fnp-4366	488	5	more	more	ADV
fnp-4366	488	6	efficient	efficient	ADJ
fnp-4366	488	7	remyelination	remyelination	NOUN
fnp-4366	488	8	in	in	ADP
fnp-4366	488	9	noms	nom	NOUN
fnp-4366	488	10	compared	compare	VERB
fnp-4366	488	11	to	to	ADP
fnp-4366	488	12	loms	lom	NOUN
fnp-4366	488	13	.	.	PUNCT
fnp-4366	489	1	importantly	importantly	ADV
fnp-4366	489	2	,	,	PUNCT
fnp-4366	489	3	we	we	PRON
fnp-4366	489	4	show	show	VERB
fnp-4366	489	5	that	that	SCONJ
fnp-4366	489	6	a	a	DET
fnp-4366	489	7	higher	high	ADJ
fnp-4366	489	8	edss	edss	ADV
fnp-4366	489	9	at	at	ADP
fnp-4366	489	10	last	last	ADJ
fnp-4366	489	11	follow	follow	NOUN
fnp-4366	489	12	-	-	PUNCT
fnp-4366	489	13	up	up	NOUN
fnp-4366	489	14	in	in	ADP
fnp-4366	489	15	loms	lom	NOUN
fnp-4366	489	16	patients	patient	NOUN
fnp-4366	489	17	negatively	negatively	ADV
fnp-4366	489	18	correlates	correlate	VERB
fnp-4366	489	19	with	with	ADP
fnp-4366	489	20	the	the	DET
fnp-4366	489	21	number	number	NOUN
fnp-4366	489	22	of	of	ADP
fnp-4366	489	23	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	489	24	within	within	ADP
fnp-4366	489	25	lesions	lesion	NOUN
fnp-4366	489	26	,	,	PUNCT
fnp-4366	489	27	emphasizing	emphasize	VERB
fnp-4366	489	28	the	the	DET
fnp-4366	489	29	importance	importance	NOUN
fnp-4366	489	30	of	of	ADP
fnp-4366	489	31	a	a	DET
fnp-4366	489	32	loss	loss	NOUN
fnp-4366	489	33	of	of	ADP
fnp-4366	489	34	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	489	35	for	for	ADP
fnp-4366	489	36	clinical	clinical	ADJ
fnp-4366	489	37	disability	disability	NOUN
fnp-4366	489	38	.	.	PUNCT
fnp-4366	490	1	study	study	NOUN
fnp-4366	490	2	supported	support	VERB
fnp-4366	490	3	by	by	ADP
fnp-4366	490	4	sanofi	sanofi	PROPN
fnp-4366	490	5	genzyme	genzyme	PROPN
fnp-4366	490	6	.	.	PUNCT
fnp-4366	490	7	  	  	SPACE
fnp-4366	490	8	4.03	4.03	NUM
fnp-4366	490	9	free	free	ADJ
fnp-4366	490	10	neuropathol	neuropathol	NOUN
fnp-4366	490	11	3:20:47	3:20:47	PROPN
fnp-4366	490	12	schwann	schwann	PROPN
fnp-4366	490	13	cell	cell	NOUN
fnp-4366	490	14	remyelination	remyelination	NOUN
fnp-4366	490	15	is	be	AUX
fnp-4366	490	16	a	a	DET
fnp-4366	490	17	salient	salient	ADJ
fnp-4366	490	18	feature	feature	NOUN
fnp-4366	490	19	of	of	ADP
fnp-4366	490	20	spinal	spinal	ADJ
fnp-4366	490	21	nmo	nmo	NOUN
fnp-4366	490	22	with	with	ADP
fnp-4366	490	23	neuroprotective	neuroprotective	ADJ
fnp-4366	490	24	potential	potential	ADJ
fnp-4366	490	25	carolina	carolina	PROPN
fnp-4366	490	26	thomas1,2	thomas1,2	PROPN
fnp-4366	490	27	,	,	PUNCT
fnp-4366	490	28	josephine	josephine	PROPN
fnp-4366	490	29	sophia	sophia	PROPN
fnp-4366	490	30	owens1	owens1	PROPN
fnp-4366	490	31	,	,	PUNCT
fnp-4366	490	32	parinaz	parinaz	PROPN
fnp-4366	490	33	yavarzadeh1	yavarzadeh1	PROPN
fnp-4366	490	34	,	,	PUNCT
fnp-4366	490	35	anne	anne	PROPN
fnp-4366	490	36	winkler1	winkler1	PROPN
fnp-4366	490	37	,	,	PUNCT
fnp-4366	490	38	christine	christine	PROPN
fnp-4366	490	39	stadelmann1	stadelmann1	VERB
fnp-4366	490	40	1	1	NUM
fnp-4366	490	41	institut	institut	PROPN
fnp-4366	490	42	für	für	PROPN
fnp-4366	490	43	neuropathologie	neuropathologie	PROPN
fnp-4366	490	44	universitätsmedizin	universitätsmedizin	PROPN
fnp-4366	490	45	göttingen	göttingen	PROPN
fnp-4366	490	46	,	,	PUNCT
fnp-4366	490	47	göttingen	göttingen	NOUN
fnp-4366	490	48	,	,	PUNCT
fnp-4366	490	49	deutschland	deutschland	NOUN
fnp-4366	490	50	2	2	NUM
fnp-4366	490	51	max	max	PROPN
fnp-4366	490	52	-	-	PUNCT
fnp-4366	490	53	planck	planck	NOUN
fnp-4366	490	54	-	-	PUNCT
fnp-4366	490	55	institut	institut	PROPN
fnp-4366	490	56	für	für	PROPN
fnp-4366	490	57	multidisziplinäre	multidisziplinäre	PROPN
fnp-4366	490	58	naturwissenschaften	naturwissenschaften	PROPN
fnp-4366	490	59	,	,	PUNCT
fnp-4366	490	60	city	city	NOUN
fnp-4366	490	61	campus	campus	NOUN
fnp-4366	490	62	abteilung	abteilung	PROPN
fnp-4366	490	63	molekulare	molekulare	PROPN
fnp-4366	490	64	neurobiologie	neurobiologie	PROPN
fnp-4366	490	65	,	,	PUNCT
fnp-4366	490	66	göttingen	göttingen	NOUN
fnp-4366	490	67	,	,	PUNCT
fnp-4366	490	68	deutschland	deutschland	NOUN
fnp-4366	490	69	background	background	NOUN
fnp-4366	490	70	:	:	PUNCT
fnp-4366	490	71	neuromyelitis	neuromyelitis	PROPN
fnp-4366	490	72	optica	optica	PROPN
fnp-4366	490	73	(	(	PUNCT
fnp-4366	490	74	nmo	nmo	PROPN
fnp-4366	490	75	)	)	PUNCT
fnp-4366	490	76	is	be	AUX
fnp-4366	490	77	a	a	DET
fnp-4366	490	78	severe	severe	ADJ
fnp-4366	490	79	autoimmune	autoimmune	ADJ
fnp-4366	490	80	demyelinating	demyelinate	VERB
fnp-4366	490	81	disorder	disorder	NOUN
fnp-4366	490	82	characterized	characterize	VERB
fnp-4366	490	83	by	by	ADP
fnp-4366	490	84	the	the	DET
fnp-4366	490	85	presence	presence	NOUN
fnp-4366	490	86	of	of	ADP
fnp-4366	490	87	pathogenic	pathogenic	ADJ
fnp-4366	490	88	autoantibodies	autoantibody	NOUN
fnp-4366	490	89	against	against	ADP
fnp-4366	490	90	the	the	DET
fnp-4366	490	91	water	water	NOUN
fnp-4366	490	92	channel	channel	PROPN
fnp-4366	490	93	aquaporin-4	aquaporin-4	PROPN
fnp-4366	490	94	,	,	PUNCT
fnp-4366	490	95	and	and	CCONJ
fnp-4366	490	96	clinically	clinically	ADV
fnp-4366	490	97	by	by	ADP
fnp-4366	490	98	extensive	extensive	ADJ
fnp-4366	490	99	myelitis	myelitis	NOUN
fnp-4366	490	100	with	with	ADP
fnp-4366	490	101	optic	optic	ADJ
fnp-4366	490	102	neuritis	neuritis	NOUN
fnp-4366	490	103	.	.	PUNCT
fnp-4366	491	1	intriguingly	intriguingly	ADV
fnp-4366	491	2	,	,	PUNCT
fnp-4366	491	3	despite	despite	SCONJ
fnp-4366	491	4	the	the	DET
fnp-4366	491	5	complete	complete	ADJ
fnp-4366	491	6	loss	loss	NOUN
fnp-4366	491	7	of	of	ADP
fnp-4366	491	8	astrocytes	astrocyte	NOUN
fnp-4366	491	9	with	with	ADP
fnp-4366	491	10	consecutive	consecutive	ADJ
fnp-4366	491	11	damage	damage	NOUN
fnp-4366	491	12	and	and	CCONJ
fnp-4366	491	13	reduction	reduction	NOUN
fnp-4366	491	14	of	of	ADP
fnp-4366	491	15	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	491	16	,	,	PUNCT
fnp-4366	491	17	a	a	DET
fnp-4366	491	18	partial	partial	ADJ
fnp-4366	491	19	remyelination	remyelination	NOUN
fnp-4366	491	20	of	of	ADP
fnp-4366	491	21	nmo	nmo	NOUN
fnp-4366	491	22	lesions	lesion	NOUN
fnp-4366	491	23	has	have	AUX
fnp-4366	491	24	been	be	AUX
fnp-4366	491	25	previously	previously	ADV
fnp-4366	491	26	described	describe	VERB
fnp-4366	491	27	.	.	PUNCT
fnp-4366	492	1	aims	aim	VERB
fnp-4366	492	2	:	:	PUNCT
fnp-4366	492	3	here	here	ADV
fnp-4366	492	4	we	we	PRON
fnp-4366	492	5	aimed	aim	VERB
fnp-4366	492	6	to	to	PART
fnp-4366	492	7	decipher	decipher	VERB
fnp-4366	492	8	the	the	DET
fnp-4366	492	9	cellular	cellular	ADJ
fnp-4366	492	10	components	component	NOUN
fnp-4366	492	11	present	present	ADJ
fnp-4366	492	12	in	in	ADP
fnp-4366	492	13	remyelinated	remyelinate	VERB
fnp-4366	492	14	spinal	spinal	ADJ
fnp-4366	492	15	nmo	nmo	NOUN
fnp-4366	492	16	lesions	lesion	NOUN
fnp-4366	492	17	and	and	CCONJ
fnp-4366	492	18	to	to	PART
fnp-4366	492	19	detect	detect	VERB
fnp-4366	492	20	potential	potential	ADJ
fnp-4366	492	21	protective	protective	ADJ
fnp-4366	492	22	effects	effect	NOUN
fnp-4366	492	23	of	of	ADP
fnp-4366	492	24	remyelination	remyelination	NOUN
fnp-4366	492	25	on	on	ADP
fnp-4366	492	26	axonal	axonal	ADJ
fnp-4366	492	27	integrity	integrity	NOUN
fnp-4366	492	28	in	in	ADP
fnp-4366	492	29	these	these	DET
fnp-4366	492	30	lesions	lesion	NOUN
fnp-4366	492	31	.	.	PUNCT
fnp-4366	493	1	methods	method	NOUN
fnp-4366	493	2	:	:	PUNCT
fnp-4366	493	3	we	we	PRON
fnp-4366	493	4	performed	perform	VERB
fnp-4366	493	5	post	post	ADJ
fnp-4366	493	6	-	-	ADJ
fnp-4366	493	7	mortem	mortem	ADJ
fnp-4366	493	8	histopathological	histopathological	ADJ
fnp-4366	493	9	and	and	CCONJ
fnp-4366	493	10	immunohistochemical	immunohistochemical	ADJ
fnp-4366	493	11	examination	examination	NOUN
fnp-4366	493	12	of	of	ADP
fnp-4366	493	13	spinal	spinal	ADJ
fnp-4366	493	14	lesions	lesion	NOUN
fnp-4366	493	15	from	from	ADP
fnp-4366	493	16	a	a	DET
fnp-4366	493	17	cohort	cohort	NOUN
fnp-4366	493	18	of	of	ADP
fnp-4366	493	19	8	8	NUM
fnp-4366	493	20	patients	patient	NOUN
fnp-4366	493	21	.	.	PUNCT
fnp-4366	494	1	results	result	NOUN
fnp-4366	494	2	:	:	PUNCT
fnp-4366	494	3	we	we	PRON
fnp-4366	494	4	demonstrate	demonstrate	VERB
fnp-4366	494	5	that	that	SCONJ
fnp-4366	494	6	schwann	schwann	PROPN
fnp-4366	494	7	cells	cell	NOUN
fnp-4366	494	8	(	(	PUNCT
fnp-4366	494	9	sc	sc	PROPN
fnp-4366	494	10	)	)	PUNCT
fnp-4366	494	11	are	be	AUX
fnp-4366	494	12	present	present	ADJ
fnp-4366	494	13	and	and	CCONJ
fnp-4366	494	14	are	be	AUX
fnp-4366	494	15	in	in	ADP
fnp-4366	494	16	part	part	NOUN
fnp-4366	494	17	responsible	responsible	ADJ
fnp-4366	494	18	for	for	ADP
fnp-4366	494	19	remyelination	remyelination	NOUN
fnp-4366	494	20	of	of	ADP
fnp-4366	494	21	nmo	nmo	NOUN
fnp-4366	494	22	lesions	lesion	NOUN
fnp-4366	494	23	.	.	PUNCT
fnp-4366	495	1	furthermore	furthermore	ADV
fnp-4366	495	2	,	,	PUNCT
fnp-4366	495	3	we	we	PRON
fnp-4366	495	4	show	show	VERB
fnp-4366	495	5	a	a	DET
fnp-4366	495	6	greater	great	ADJ
fnp-4366	495	7	abundance	abundance	NOUN
fnp-4366	495	8	of	of	ADP
fnp-4366	495	9	remyelination	remyelination	NOUN
fnp-4366	495	10	in	in	ADP
fnp-4366	495	11	the	the	DET
fnp-4366	495	12	lesions	lesion	NOUN
fnp-4366	495	13	localized	localize	VERB
fnp-4366	495	14	along	along	ADP
fnp-4366	495	15	peripheral	peripheral	ADJ
fnp-4366	495	16	nerve	nerve	NOUN
fnp-4366	495	17	entry	entry	NOUN
fnp-4366	495	18	-	-	PUNCT
fnp-4366	495	19	exit	exit	NOUN
fnp-4366	495	20	zones	zone	NOUN
fnp-4366	495	21	as	as	ADV
fnp-4366	495	22	well	well	ADV
fnp-4366	495	23	as	as	ADP
fnp-4366	495	24	perivascularly	perivascularly	ADV
fnp-4366	495	25	.	.	PUNCT
fnp-4366	496	1	in	in	ADP
fnp-4366	496	2	addition	addition	NOUN
fnp-4366	496	3	,	,	PUNCT
fnp-4366	496	4	no	no	DET
fnp-4366	496	5	sc	sc	NOUN
fnp-4366	496	6	remyelination	remyelination	NOUN
fnp-4366	496	7	was	be	AUX
fnp-4366	496	8	observed	observe	VERB
fnp-4366	496	9	in	in	ADP
fnp-4366	496	10	spinal	spinal	ADJ
fnp-4366	496	11	lesions	lesion	NOUN
fnp-4366	496	12	of	of	ADP
fnp-4366	496	13	patients	patient	NOUN
fnp-4366	496	14	suffering	suffer	VERB
fnp-4366	496	15	from	from	ADP
fnp-4366	496	16	multiple	multiple	ADJ
fnp-4366	496	17	sclerosis	sclerosis	NOUN
fnp-4366	496	18	.	.	PUNCT
fnp-4366	497	1	finally	finally	ADV
fnp-4366	497	2	,	,	PUNCT
fnp-4366	497	3	axonal	axonal	ADJ
fnp-4366	497	4	density	density	NOUN
fnp-4366	497	5	was	be	AUX
fnp-4366	497	6	partially	partially	ADV
fnp-4366	497	7	preserved	preserve	VERB
fnp-4366	497	8	in	in	ADP
fnp-4366	497	9	sc	sc	PROPN
fnp-4366	497	10	remyelinated	remyelinate	VERB
fnp-4366	497	11	areas	area	NOUN
fnp-4366	497	12	.	.	PUNCT
fnp-4366	498	1	conclusions	conclusion	NOUN
fnp-4366	498	2	:	:	PUNCT
fnp-4366	498	3	taken	take	VERB
fnp-4366	498	4	together	together	ADV
fnp-4366	498	5	,	,	PUNCT
fnp-4366	498	6	our	our	PRON
fnp-4366	498	7	results	result	NOUN
fnp-4366	498	8	indicate	indicate	VERB
fnp-4366	498	9	that	that	SCONJ
fnp-4366	498	10	scr	scr	NOUN
fnp-4366	498	11	is	be	AUX
fnp-4366	498	12	an	an	DET
fnp-4366	498	13	exclusive	exclusive	ADJ
fnp-4366	498	14	feature	feature	NOUN
fnp-4366	498	15	of	of	ADP
fnp-4366	498	16	nmo	nmo	NOUN
fnp-4366	498	17	that	that	PRON
fnp-4366	498	18	requires	require	VERB
fnp-4366	498	19	a	a	DET
fnp-4366	498	20	breaching	breaching	NOUN
fnp-4366	498	21	of	of	ADP
fnp-4366	498	22	the	the	DET
fnp-4366	498	23	glia	glia	NOUN
fnp-4366	498	24	limitans	limitan	NOUN
fnp-4366	498	25	with	with	ADP
fnp-4366	498	26	potential	potential	ADJ
fnp-4366	498	27	neuroprotective	neuroprotective	ADJ
fnp-4366	498	28	effects	effect	NOUN
fnp-4366	498	29	.	.	PUNCT
fnp-4366	498	30	  	  	SPACE
fnp-4366	499	1	5	5	NUM
fnp-4366	499	2	.	.	X
fnp-4366	499	3	muscle	muscle	NOUN
fnp-4366	499	4	/	/	SYM
fnp-4366	499	5	nerve	nerve	NOUN
fnp-4366	499	6	5.01	5.01	NUM
fnp-4366	499	7	free	free	ADJ
fnp-4366	499	8	neuropathol	neuropathol	NOUN
fnp-4366	500	1	3:20:48	3:20:48	NUM
fnp-4366	500	2	molecular	molecular	ADJ
fnp-4366	500	3	profiling	profiling	NOUN
fnp-4366	500	4	of	of	ADP
fnp-4366	500	5	skeletal	skeletal	ADJ
fnp-4366	500	6	muscle	muscle	NOUN
fnp-4366	500	7	in	in	ADP
fnp-4366	500	8	infantile	infantile	ADJ
fnp-4366	500	9	,	,	PUNCT
fnp-4366	500	10	juvenile	juvenile	ADJ
fnp-4366	500	11	and	and	CCONJ
fnp-4366	500	12	adult	adult	NOUN
fnp-4366	500	13	patients	patient	NOUN
fnp-4366	500	14	with	with	ADP
fnp-4366	500	15	pompe	pompe	PROPN
fnp-4366	500	16	disease	disease	PROPN
fnp-4366	500	17	alexander	alexander	PROPN
fnp-4366	500	18	schaiter1	schaiter1	PROPN
fnp-4366	500	19	,	,	PUNCT
fnp-4366	500	20	andreas	andreas	PROPN
fnp-4366	500	21	roos2,3,4	roos2,3,4	PROPN
fnp-4366	500	22	,	,	PUNCT
fnp-4366	500	23	andreas	andreas	PROPN
fnp-4366	500	24	hentschel5	hentschel5	PROPN
fnp-4366	500	25	,	,	PUNCT
fnp-4366	500	26	andreas	andreas	PROPN
fnp-4366	500	27	hahn6	hahn6	PROPN
fnp-4366	500	28	,	,	PUNCT
fnp-4366	500	29	marek	marek	PROPN
fnp-4366	500	30	bartkuhn7,8	bartkuhn7,8	PROPN
fnp-4366	500	31	,	,	PUNCT
fnp-4366	500	32	anne	anne	PROPN
fnp-4366	500	33	schänzer1	schänzer1	PROPN
fnp-4366	500	34	1	1	NUM
fnp-4366	500	35	institute	institute	NOUN
fnp-4366	500	36	of	of	ADP
fnp-4366	500	37	neuropathology	neuropathology	NOUN
fnp-4366	500	38	,	,	PUNCT
fnp-4366	500	39	justus	justus	PROPN
fnp-4366	500	40	liebig	liebig	PROPN
fnp-4366	500	41	university	university	PROPN
fnp-4366	500	42	,	,	PUNCT
fnp-4366	500	43	giessen	giessen	VERB
fnp-4366	500	44	,	,	PUNCT
fnp-4366	500	45	deutschland	deutschland	NOUN
fnp-4366	500	46	2	2	NUM
fnp-4366	500	47	department	department	NOUN
fnp-4366	500	48	of	of	ADP
fnp-4366	500	49	pediatric	pediatric	ADJ
fnp-4366	500	50	neurology	neurology	NOUN
fnp-4366	500	51	,	,	PUNCT
fnp-4366	500	52	centre	centre	NOUN
fnp-4366	500	53	for	for	ADP
fnp-4366	500	54	neuromuscular	neuromuscular	ADJ
fnp-4366	500	55	disorders	disorder	NOUN
fnp-4366	500	56	,	,	PUNCT
fnp-4366	500	57	centre	centre	NOUN
fnp-4366	500	58	for	for	ADP
fnp-4366	500	59	translational	translational	ADJ
fnp-4366	500	60	neuroand	neuroand	ADJ
fnp-4366	500	61	behavioral	behavioral	ADJ
fnp-4366	500	62	sciences	sciences	PROPN
fnp-4366	500	63	,	,	PUNCT
fnp-4366	500	64	university	university	NOUN
fnp-4366	500	65	duisburg	duisburg	PROPN
fnp-4366	500	66	-	-	PUNCT
fnp-4366	500	67	essen	essen	NOUN
fnp-4366	500	68	,	,	PUNCT
fnp-4366	500	69	essen	essen	PROPN
fnp-4366	500	70	,	,	PUNCT
fnp-4366	500	71	deutschland	deutschland	NOUN
fnp-4366	500	72	3	3	NUM
fnp-4366	500	73	children	child	NOUN
fnp-4366	500	74	's	's	PART
fnp-4366	500	75	hospital	hospital	NOUN
fnp-4366	500	76	of	of	ADP
fnp-4366	500	77	eastern	eastern	PROPN
fnp-4366	500	78	ontario	ontario	PROPN
fnp-4366	500	79	research	research	PROPN
fnp-4366	500	80	institute	institute	PROPN
fnp-4366	500	81	;	;	PUNCT
fnp-4366	500	82	division	division	NOUN
fnp-4366	500	83	of	of	ADP
fnp-4366	500	84	neurology	neurology	NOUN
fnp-4366	500	85	,	,	PUNCT
fnp-4366	500	86	department	department	NOUN
fnp-4366	500	87	of	of	ADP
fnp-4366	500	88	medicine	medicine	NOUN
fnp-4366	500	89	,	,	PUNCT
fnp-4366	500	90	the	the	DET
fnp-4366	500	91	ottawa	ottawa	PROPN
fnp-4366	500	92	hospital	hospital	NOUN
fnp-4366	500	93	;	;	PUNCT
fnp-4366	500	94	and	and	CCONJ
fnp-4366	500	95	brain	brain	NOUN
fnp-4366	500	96	and	and	CCONJ
fnp-4366	500	97	mind	mind	PROPN
fnp-4366	500	98	research	research	PROPN
fnp-4366	500	99	institute	institute	PROPN
fnp-4366	500	100	,	,	PUNCT
fnp-4366	500	101	university	university	PROPN
fnp-4366	500	102	of	of	ADP
fnp-4366	500	103	ottawa	ottawa	PROPN
fnp-4366	500	104	,	,	PUNCT
fnp-4366	500	105	ottawa	ottawa	PROPN
fnp-4366	500	106	,	,	PUNCT
fnp-4366	500	107	canada	canada	PROPN
fnp-4366	500	108	4	4	NUM
fnp-4366	500	109	department	department	PROPN
fnp-4366	500	110	of	of	ADP
fnp-4366	500	111	neurology	neurology	NOUN
fnp-4366	500	112	,	,	PUNCT
fnp-4366	500	113	heimer	heimer	PROPN
fnp-4366	500	114	institute	institute	PROPN
fnp-4366	500	115	for	for	ADP
fnp-4366	500	116	muscle	muscle	NOUN
fnp-4366	500	117	research	research	NOUN
fnp-4366	500	118	,	,	PUNCT
fnp-4366	500	119	university	university	NOUN
fnp-4366	500	120	hospital	hospital	NOUN
fnp-4366	500	121	bergmannsheil	bergmannsheil	NOUN
fnp-4366	500	122	,	,	PUNCT
fnp-4366	500	123	ruhr	ruhr	NOUN
fnp-4366	500	124	-	-	PUNCT
fnp-4366	500	125	university	university	NOUN
fnp-4366	500	126	bochum	bochum	NOUN
fnp-4366	500	127	,	,	PUNCT
fnp-4366	500	128	bochum	bochum	NOUN
fnp-4366	500	129	,	,	PUNCT
fnp-4366	500	130	deutschland	deutschland	NOUN
fnp-4366	500	131	5	5	NUM
fnp-4366	500	132	leibniz	leibniz	NOUN
fnp-4366	500	133	-	-	PUNCT
fnp-4366	500	134	institute	institute	NOUN
fnp-4366	500	135	für	für	NOUN
fnp-4366	500	136	analytische	analytische	NOUN
fnp-4366	500	137	wissenschaften	wissenschaften	VERB
fnp-4366	500	138	–	–	PUNCT
fnp-4366	500	139	isas	isa	NOUN
fnp-4366	500	140	–	–	PUNCT
fnp-4366	500	141	e.v	e.v	PROPN
fnp-4366	500	142	.	.	PROPN
fnp-4366	500	143	,	,	PUNCT
fnp-4366	500	144	dortmund	dortmund	PROPN
fnp-4366	500	145	,	,	PUNCT
fnp-4366	500	146	deutschland	deutschland	NOUN
fnp-4366	500	147	6	6	NUM
fnp-4366	500	148	department	department	NOUN
fnp-4366	500	149	of	of	ADP
fnp-4366	500	150	child	child	NOUN
fnp-4366	500	151	neurology	neurology	NOUN
fnp-4366	500	152	,	,	PUNCT
fnp-4366	500	153	justus	justus	PROPN
fnp-4366	500	154	liebig	liebig	PROPN
fnp-4366	500	155	university	university	PROPN
fnp-4366	500	156	,	,	PUNCT
fnp-4366	500	157	giessen	giessen	VERB
fnp-4366	500	158	,	,	PUNCT
fnp-4366	500	159	deutschland	deutschland	NOUN
fnp-4366	500	160	7	7	NUM
fnp-4366	500	161	institute	institute	NOUN
fnp-4366	500	162	of	of	ADP
fnp-4366	500	163	biomedical	biomedical	ADJ
fnp-4366	500	164	informatics	informatic	NOUN
fnp-4366	500	165	and	and	CCONJ
fnp-4366	500	166	systems	system	NOUN
fnp-4366	500	167	medicine	medicine	NOUN
fnp-4366	500	168	science	science	NOUN
fnp-4366	500	169	unit	unit	NOUN
fnp-4366	500	170	for	for	ADP
fnp-4366	500	171	basic	basic	ADJ
fnp-4366	500	172	and	and	CCONJ
fnp-4366	500	173	clinical	clinical	ADJ
fnp-4366	500	174	medicine	medicine	NOUN
fnp-4366	500	175	,	,	PUNCT
fnp-4366	500	176	justus	justus	PROPN
fnp-4366	500	177	liebig	liebig	PROPN
fnp-4366	500	178	university	university	PROPN
fnp-4366	500	179	,	,	PUNCT
fnp-4366	500	180	giessen	giessen	VERB
fnp-4366	500	181	,	,	PUNCT
fnp-4366	500	182	deutschland	deutschland	NOUN
fnp-4366	500	183	8	8	NUM
fnp-4366	500	184	institute	institute	NOUN
fnp-4366	500	185	for	for	ADP
fnp-4366	500	186	lung	lung	PROPN
fnp-4366	500	187	health	health	PROPN
fnp-4366	500	188	(	(	PUNCT
fnp-4366	500	189	ilh	ilh	PROPN
fnp-4366	500	190	)	)	PUNCT
fnp-4366	500	191	platform	platform	NOUN
fnp-4366	500	192	for	for	ADP
fnp-4366	500	193	genomics	genomic	NOUN
fnp-4366	500	194	and	and	CCONJ
fnp-4366	500	195	bioinformatics	bioinformatics	NOUN
fnp-4366	500	196	,	,	PUNCT
fnp-4366	500	197	justus	justus	PROPN
fnp-4366	500	198	liebig	liebig	PROPN
fnp-4366	500	199	university	university	PROPN
fnp-4366	500	200	,	,	PUNCT
fnp-4366	500	201	giessen	giessen	VERB
fnp-4366	500	202	,	,	PUNCT
fnp-4366	500	203	deutschland	deutschland	NOUN
fnp-4366	500	204	introduction	introduction	NOUN
fnp-4366	500	205	:	:	PUNCT
fnp-4366	500	206	pompe	pompe	PROPN
fnp-4366	500	207	disease	disease	NOUN
fnp-4366	500	208	is	be	AUX
fnp-4366	500	209	a	a	DET
fnp-4366	500	210	lysosomal	lysosomal	ADJ
fnp-4366	500	211	metabolic	metabolic	NOUN
fnp-4366	500	212	disease	disease	NOUN
fnp-4366	500	213	caused	cause	VERB
fnp-4366	500	214	by	by	ADP
fnp-4366	500	215	mutations	mutation	NOUN
fnp-4366	500	216	in	in	ADP
fnp-4366	500	217	the	the	DET
fnp-4366	500	218	alpha	alpha	ADJ
fnp-4366	500	219	1,4	1,4	NOUN
fnp-4366	500	220	-	-	NOUN
fnp-4366	500	221	glucosidase	glucosidase	ADJ
fnp-4366	500	222	(	(	PUNCT
fnp-4366	500	223	gaa	gaa	PROPN
fnp-4366	500	224	)	)	PUNCT
fnp-4366	500	225	.	.	PUNCT
fnp-4366	501	1	the	the	DET
fnp-4366	501	2	gaa	gaa	PROPN
fnp-4366	501	3	enzyme	enzyme	NOUN
fnp-4366	501	4	defect	defect	NOUN
fnp-4366	501	5	leads	lead	VERB
fnp-4366	501	6	to	to	ADP
fnp-4366	501	7	accumulation	accumulation	NOUN
fnp-4366	501	8	of	of	ADP
fnp-4366	501	9	glycogen	glycogen	NOUN
fnp-4366	501	10	in	in	ADP
fnp-4366	501	11	striated	striated	ADJ
fnp-4366	501	12	muscles	muscle	NOUN
fnp-4366	501	13	and	and	CCONJ
fnp-4366	501	14	a	a	DET
fnp-4366	501	15	reduced	reduce	VERB
fnp-4366	501	16	muscle	muscle	NOUN
fnp-4366	501	17	function	function	NOUN
fnp-4366	501	18	.	.	PUNCT
fnp-4366	502	1	pompe	pompe	PROPN
fnp-4366	502	2	disease	disease	NOUN
fnp-4366	502	3	is	be	AUX
fnp-4366	502	4	categorized	categorize	VERB
fnp-4366	502	5	in	in	ADP
fnp-4366	502	6	infantile	infantile	ADJ
fnp-4366	502	7	onset	onset	NOUN
fnp-4366	502	8	(	(	PUNCT
fnp-4366	502	9	iopd	iopd	NOUN
fnp-4366	502	10	)	)	PUNCT
fnp-4366	502	11	and	and	CCONJ
fnp-4366	502	12	late	late	ADJ
fnp-4366	502	13	onset	onset	NOUN
fnp-4366	502	14	(	(	PUNCT
fnp-4366	502	15	lopd	lopd	NOUN
fnp-4366	502	16	)	)	PUNCT
fnp-4366	502	17	based	base	VERB
fnp-4366	502	18	on	on	ADP
fnp-4366	502	19	gaa	gaa	PROPN
fnp-4366	502	20	residual	residual	ADJ
fnp-4366	502	21	activity	activity	NOUN
fnp-4366	502	22	,	,	PUNCT
fnp-4366	502	23	genetic	genetic	ADJ
fnp-4366	502	24	profile	profile	NOUN
fnp-4366	502	25	and	and	CCONJ
fnp-4366	502	26	clinical	clinical	ADJ
fnp-4366	502	27	manifestation	manifestation	NOUN
fnp-4366	502	28	.	.	PUNCT
fnp-4366	503	1	furthermore	furthermore	ADV
fnp-4366	503	2	,	,	PUNCT
fnp-4366	503	3	a	a	DET
fnp-4366	503	4	juvenile	juvenile	ADJ
fnp-4366	503	5	onset	onset	NOUN
fnp-4366	503	6	is	be	AUX
fnp-4366	503	7	described	describe	VERB
fnp-4366	503	8	,	,	PUNCT
fnp-4366	503	9	which	which	PRON
fnp-4366	503	10	is	be	AUX
fnp-4366	503	11	classified	classify	VERB
fnp-4366	503	12	as	as	ADP
fnp-4366	503	13	lopd	lopd	NOUN
fnp-4366	503	14	.	.	PUNCT
fnp-4366	504	1	the	the	DET
fnp-4366	504	2	underlying	underlie	VERB
fnp-4366	504	3	mechanisms	mechanism	NOUN
fnp-4366	504	4	of	of	ADP
fnp-4366	504	5	pompe	pompe	PROPN
fnp-4366	504	6	disease	disease	NOUN
fnp-4366	504	7	are	be	AUX
fnp-4366	504	8	still	still	ADV
fnp-4366	504	9	unknown	unknown	ADJ
fnp-4366	504	10	.	.	PUNCT
fnp-4366	505	1	molecular	molecular	ADJ
fnp-4366	505	2	signatures	signature	NOUN
fnp-4366	505	3	of	of	ADP
fnp-4366	505	4	iopd	iopd	NOUN
fnp-4366	505	5	,	,	PUNCT
fnp-4366	505	6	lopd	lopd	NOUN
fnp-4366	505	7	and	and	CCONJ
fnp-4366	505	8	juvenile	juvenile	ADJ
fnp-4366	505	9	patients	patient	NOUN
fnp-4366	505	10	are	be	AUX
fnp-4366	505	11	rare	rare	ADJ
fnp-4366	505	12	.	.	PUNCT
fnp-4366	506	1	the	the	DET
fnp-4366	506	2	aim	aim	NOUN
fnp-4366	506	3	of	of	ADP
fnp-4366	506	4	this	this	DET
fnp-4366	506	5	study	study	NOUN
fnp-4366	506	6	is	be	AUX
fnp-4366	506	7	to	to	PART
fnp-4366	506	8	identify	identify	VERB
fnp-4366	506	9	specific	specific	ADJ
fnp-4366	506	10	differences	difference	NOUN
fnp-4366	506	11	between	between	ADP
fnp-4366	506	12	the	the	DET
fnp-4366	506	13	subgroups	subgroup	NOUN
fnp-4366	506	14	of	of	ADP
fnp-4366	506	15	pompe	pompe	PROPN
fnp-4366	506	16	disease	disease	NOUN
fnp-4366	506	17	using	use	VERB
fnp-4366	506	18	proteomic	proteomic	ADJ
fnp-4366	506	19	analysis	analysis	NOUN
fnp-4366	506	20	.	.	PUNCT
fnp-4366	507	1	the	the	DET
fnp-4366	507	2	first	first	ADJ
fnp-4366	507	3	objective	objective	NOUN
fnp-4366	507	4	is	be	AUX
fnp-4366	507	5	to	to	PART
fnp-4366	507	6	find	find	VERB
fnp-4366	507	7	novel	novel	ADJ
fnp-4366	507	8	protein	protein	NOUN
fnp-4366	507	9	expressions	expression	NOUN
fnp-4366	507	10	associated	associate	VERB
fnp-4366	507	11	with	with	ADP
fnp-4366	507	12	the	the	DET
fnp-4366	507	13	subgroups	subgroup	NOUN
fnp-4366	507	14	of	of	ADP
fnp-4366	507	15	pompe	pompe	PROPN
fnp-4366	507	16	disease	disease	PROPN
fnp-4366	507	17	.	.	PUNCT
fnp-4366	508	1	the	the	DET
fnp-4366	508	2	second	second	ADJ
fnp-4366	508	3	objective	objective	NOUN
fnp-4366	508	4	is	be	AUX
fnp-4366	508	5	to	to	PART
fnp-4366	508	6	compare	compare	VERB
fnp-4366	508	7	the	the	DET
fnp-4366	508	8	proteomic	proteomic	ADJ
fnp-4366	508	9	profiles	profile	NOUN
fnp-4366	508	10	of	of	ADP
fnp-4366	508	11	the	the	DET
fnp-4366	508	12	subgroups	subgroup	NOUN
fnp-4366	508	13	with	with	ADP
fnp-4366	508	14	each	each	DET
fnp-4366	508	15	other	other	ADJ
fnp-4366	508	16	to	to	PART
fnp-4366	508	17	prove	prove	VERB
fnp-4366	508	18	the	the	DET
fnp-4366	508	19	categorization	categorization	NOUN
fnp-4366	508	20	by	by	ADP
fnp-4366	508	21	a	a	DET
fnp-4366	508	22	proteomic	proteomic	ADJ
fnp-4366	508	23	approach	approach	NOUN
fnp-4366	508	24	.	.	PUNCT
fnp-4366	509	1	material	material	NOUN
fnp-4366	509	2	and	and	CCONJ
fnp-4366	509	3	methods	method	NOUN
fnp-4366	509	4	:	:	PUNCT
fnp-4366	509	5	skeletal	skeletal	ADJ
fnp-4366	509	6	muscle	muscle	NOUN
fnp-4366	509	7	biopsies	biopsy	NOUN
fnp-4366	509	8	from	from	ADP
fnp-4366	509	9	35	35	NUM
fnp-4366	509	10	patients	patient	NOUN
fnp-4366	509	11	with	with	ADP
fnp-4366	509	12	pompe	pompe	PROPN
fnp-4366	509	13	disease	disease	NOUN
fnp-4366	509	14	before	before	ADP
fnp-4366	509	15	start	start	NOUN
fnp-4366	509	16	of	of	ADP
fnp-4366	509	17	enzyme	enzyme	NOUN
fnp-4366	509	18	replacement	replacement	NOUN
fnp-4366	509	19	therapy	therapy	NOUN
fnp-4366	509	20	(	(	PUNCT
fnp-4366	509	21	ert	ert	PROPN
fnp-4366	509	22	)	)	PUNCT
fnp-4366	509	23	(	(	PUNCT
fnp-4366	509	24	lopd	lopd	NOUN
fnp-4366	509	25	n=22	n=22	PROPN
fnp-4366	509	26	,	,	PUNCT
fnp-4366	509	27	iopd	iopd	NOUN
fnp-4366	509	28	n=11	n=11	PROPN
fnp-4366	509	29	,	,	PUNCT
fnp-4366	509	30	juvenile	juvenile	ADJ
fnp-4366	509	31	n=2	n=2	ADV
fnp-4366	509	32	)	)	PUNCT
fnp-4366	509	33	and	and	CCONJ
fnp-4366	509	34	21	21	NUM
fnp-4366	509	35	age	age	NOUN
fnp-4366	509	36	matched	match	VERB
fnp-4366	509	37	controls	control	NOUN
fnp-4366	509	38	(	(	PUNCT
fnp-4366	509	39	adult	adult	NOUN
fnp-4366	509	40	n=11	n=11	NOUN
fnp-4366	509	41	,	,	PUNCT
fnp-4366	509	42	infantile	infantile	ADJ
fnp-4366	509	43	n=10	n=10	NOUN
fnp-4366	509	44	)	)	PUNCT
fnp-4366	509	45	were	be	AUX
fnp-4366	509	46	analysed	analyse	VERB
fnp-4366	509	47	using	use	VERB
fnp-4366	509	48	mass	mass	NOUN
fnp-4366	509	49	-	-	PUNCT
fnp-4366	509	50	spectrometry	spectrometry	NOUN
fnp-4366	509	51	in	in	ADP
fnp-4366	509	52	an	an	DET
fnp-4366	509	53	lfq	lfq	NOUN
fnp-4366	509	54	(	(	PUNCT
fnp-4366	509	55	label	label	NOUN
fnp-4366	509	56	-	-	PUNCT
fnp-4366	509	57	free	free	ADJ
fnp-4366	509	58	-	-	PUNCT
fnp-4366	509	59	quantification	quantification	NOUN
fnp-4366	509	60	)	)	PUNCT
fnp-4366	509	61	experiment	experiment	NOUN
fnp-4366	509	62	.	.	PUNCT
fnp-4366	510	1	to	to	PART
fnp-4366	510	2	identify	identify	VERB
fnp-4366	510	3	significantly	significantly	ADV
fnp-4366	510	4	up	up	ADV
fnp-4366	510	5	or	or	CCONJ
fnp-4366	510	6	down	down	ADV
fnp-4366	510	7	regulated	regulated	ADJ
fnp-4366	510	8	proteins	protein	NOUN
fnp-4366	510	9	between	between	ADP
fnp-4366	510	10	the	the	DET
fnp-4366	510	11	groups	group	NOUN
fnp-4366	510	12	,	,	PUNCT
fnp-4366	510	13	the	the	DET
fnp-4366	510	14	raw	raw	ADJ
fnp-4366	510	15	proteomic	proteomic	ADJ
fnp-4366	510	16	data	datum	NOUN
fnp-4366	510	17	was	be	AUX
fnp-4366	510	18	further	far	ADV
fnp-4366	510	19	processed	process	VERB
fnp-4366	510	20	using	use	VERB
fnp-4366	510	21	maxquant	maxquant	NOUN
fnp-4366	510	22	,	,	PUNCT
fnp-4366	510	23	perseus	perseus	NOUN
fnp-4366	510	24	and	and	CCONJ
fnp-4366	510	25	the	the	DET
fnp-4366	510	26	r	r	NOUN
fnp-4366	510	27	-	-	PUNCT
fnp-4366	510	28	programming	programming	NOUN
fnp-4366	510	29	language	language	NOUN
fnp-4366	510	30	.	.	PUNCT
fnp-4366	511	1	principal	principal	ADJ
fnp-4366	511	2	component	component	NOUN
fnp-4366	511	3	analysis	analysis	NOUN
fnp-4366	511	4	(	(	PUNCT
fnp-4366	511	5	pca	pca	NOUN
fnp-4366	511	6	)	)	PUNCT
fnp-4366	511	7	and	and	CCONJ
fnp-4366	511	8	hierarchical	hierarchical	ADJ
fnp-4366	511	9	clustering	clustering	NOUN
fnp-4366	511	10	was	be	AUX
fnp-4366	511	11	used	use	VERB
fnp-4366	511	12	to	to	PART
fnp-4366	511	13	show	show	VERB
fnp-4366	511	14	statistical	statistical	ADJ
fnp-4366	511	15	difference	difference	NOUN
fnp-4366	511	16	between	between	ADP
fnp-4366	511	17	the	the	DET
fnp-4366	511	18	sample	sample	NOUN
fnp-4366	511	19	groups	group	NOUN
fnp-4366	511	20	.	.	PUNCT
fnp-4366	512	1	further	far	ADV
fnp-4366	512	2	,	,	PUNCT
fnp-4366	512	3	a	a	DET
fnp-4366	512	4	pathway	pathway	NOUN
fnp-4366	512	5	analysis	analysis	NOUN
fnp-4366	512	6	of	of	ADP
fnp-4366	512	7	the	the	DET
fnp-4366	512	8	significantly	significantly	ADV
fnp-4366	512	9	associated	associated	ADJ
fnp-4366	512	10	proteins	protein	NOUN
fnp-4366	512	11	using	use	VERB
fnp-4366	512	12	the	the	DET
fnp-4366	512	13	kegg	kegg	NOUN
fnp-4366	512	14	and	and	CCONJ
fnp-4366	512	15	the	the	DET
fnp-4366	512	16	gene	gene	NOUN
fnp-4366	512	17	ontology	ontology	NOUN
fnp-4366	512	18	(	(	PUNCT
fnp-4366	512	19	go	go	VERB
fnp-4366	512	20	)	)	PUNCT
fnp-4366	512	21	library	library	NOUN
fnp-4366	512	22	was	be	AUX
fnp-4366	512	23	conducted	conduct	VERB
fnp-4366	512	24	.	.	PUNCT
fnp-4366	513	1	to	to	PART
fnp-4366	513	2	validate	validate	VERB
fnp-4366	513	3	associated	associated	ADJ
fnp-4366	513	4	pathways	pathway	NOUN
fnp-4366	513	5	on	on	ADP
fnp-4366	513	6	another	another	DET
fnp-4366	513	7	approach	approach	NOUN
fnp-4366	513	8	a	a	DET
fnp-4366	513	9	gene	gene	NOUN
fnp-4366	513	10	set	set	VERB
fnp-4366	513	11	enrichment	enrichment	NOUN
fnp-4366	513	12	analysis	analysis	NOUN
fnp-4366	513	13	(	(	PUNCT
fnp-4366	513	14	gsea	gsea	NOUN
fnp-4366	513	15	)	)	PUNCT
fnp-4366	513	16	was	be	AUX
fnp-4366	513	17	calculated	calculate	VERB
fnp-4366	513	18	.	.	PUNCT
fnp-4366	514	1	to	to	PART
fnp-4366	514	2	compare	compare	VERB
fnp-4366	514	3	the	the	DET
fnp-4366	514	4	proteomic	proteomic	ADJ
fnp-4366	514	5	profile	profile	NOUN
fnp-4366	514	6	of	of	ADP
fnp-4366	514	7	lopd	lopd	NOUN
fnp-4366	514	8	,	,	PUNCT
fnp-4366	514	9	iopd	iopd	NOUN
fnp-4366	514	10	and	and	CCONJ
fnp-4366	514	11	juvenile	juvenile	ADJ
fnp-4366	514	12	,	,	PUNCT
fnp-4366	514	13	the	the	DET
fnp-4366	514	14	most	most	ADV
fnp-4366	514	15	significant	significant	ADJ
fnp-4366	514	16	proteins	protein	NOUN
fnp-4366	514	17	of	of	ADP
fnp-4366	514	18	each	each	DET
fnp-4366	514	19	group	group	NOUN
fnp-4366	514	20	were	be	AUX
fnp-4366	514	21	defined	define	VERB
fnp-4366	514	22	as	as	ADP
fnp-4366	514	23	gene	gene	NOUN
fnp-4366	514	24	-	-	PUNCT
fnp-4366	514	25	sets	set	NOUN
fnp-4366	514	26	in	in	ADP
fnp-4366	514	27	gsea	gsea	NOUN
fnp-4366	514	28	.	.	PUNCT
fnp-4366	515	1	results	result	NOUN
fnp-4366	515	2	:	:	PUNCT
fnp-4366	515	3	in	in	ADP
fnp-4366	515	4	the	the	DET
fnp-4366	515	5	iopd	iopd	NOUN
fnp-4366	515	6	13	13	NUM
fnp-4366	515	7	proteins	protein	NOUN
fnp-4366	515	8	were	be	AUX
fnp-4366	515	9	up	up	ADV
fnp-4366	515	10	-	-	PUNCT
fnp-4366	515	11	regulated	regulate	VERB
fnp-4366	515	12	and	and	CCONJ
fnp-4366	515	13	11	11	NUM
fnp-4366	515	14	downregulated	downregulate	VERB
fnp-4366	515	15	compared	compare	VERB
fnp-4366	515	16	to	to	ADP
fnp-4366	515	17	controls	control	NOUN
fnp-4366	515	18	.	.	PUNCT
fnp-4366	516	1	analyses	analysis	NOUN
fnp-4366	516	2	of	of	ADP
fnp-4366	516	3	juvenile	juvenile	ADJ
fnp-4366	516	4	pompe	pompe	NOUN
fnp-4366	516	5	showed	show	VERB
fnp-4366	516	6	7	7	NUM
fnp-4366	516	7	up	up	ADV
fnp-4366	516	8	-	-	PUNCT
fnp-4366	516	9	regulated	regulate	VERB
fnp-4366	516	10	,	,	PUNCT
fnp-4366	516	11	37	37	NUM
fnp-4366	516	12	downregulated	downregulate	VERB
fnp-4366	516	13	and	and	CCONJ
fnp-4366	516	14	in	in	ADP
fnp-4366	516	15	lopd	lopd	NOUN
fnp-4366	516	16	19	19	NUM
fnp-4366	516	17	up	up	ADV
fnp-4366	516	18	-	-	PUNCT
fnp-4366	516	19	regulated	regulate	VERB
fnp-4366	516	20	,	,	PUNCT
fnp-4366	516	21	47	47	NUM
fnp-4366	516	22	down	down	ADV
fnp-4366	516	23	-	-	PUNCT
fnp-4366	516	24	regulated	regulate	VERB
fnp-4366	516	25	proteins	protein	NOUN
fnp-4366	516	26	.	.	PUNCT
fnp-4366	517	1	the	the	DET
fnp-4366	517	2	samples	sample	NOUN
fnp-4366	517	3	of	of	ADP
fnp-4366	517	4	lopd	lopd	NOUN
fnp-4366	517	5	and	and	CCONJ
fnp-4366	517	6	juvenile	juvenile	ADJ
fnp-4366	517	7	shared	share	VERB
fnp-4366	517	8	certain	certain	ADJ
fnp-4366	517	9	protein	protein	NOUN
fnp-4366	517	10	expression	expression	NOUN
fnp-4366	517	11	e.g.	e.g.	ADV
fnp-4366	517	12	fbn1	fbn1	PROPN
fnp-4366	517	13	,	,	PUNCT
fnp-4366	517	14	col1a2	col1a2	NOUN
fnp-4366	517	15	and	and	CCONJ
fnp-4366	517	16	col3a1	col3a1	NOUN
fnp-4366	517	17	were	be	AUX
fnp-4366	517	18	down	down	ADV
fnp-4366	517	19	-	-	PUNCT
fnp-4366	517	20	regulated	regulate	VERB
fnp-4366	517	21	in	in	ADP
fnp-4366	517	22	both	both	DET
fnp-4366	517	23	groups	group	NOUN
fnp-4366	517	24	.	.	PUNCT
fnp-4366	518	1	however	however	ADV
fnp-4366	518	2	,	,	PUNCT
fnp-4366	518	3	iopd	iopd	NOUN
fnp-4366	518	4	and	and	CCONJ
fnp-4366	518	5	lopd	lopd	NOUN
fnp-4366	518	6	showed	show	VERB
fnp-4366	518	7	divergent	divergent	ADJ
fnp-4366	518	8	expression	expression	NOUN
fnp-4366	518	9	e.g.	e.g.	ADV
fnp-4366	518	10	hk1	hk1	NOUN
fnp-4366	518	11	(	(	PUNCT
fnp-4366	518	12	phosphorylation	phosphorylation	NOUN
fnp-4366	518	13	of	of	ADP
fnp-4366	518	14	various	various	ADJ
fnp-4366	518	15	hexoses	hexose	NOUN
fnp-4366	518	16	and	and	CCONJ
fnp-4366	518	17	involved	involve	VERB
fnp-4366	518	18	in	in	ADP
fnp-4366	518	19	innate	innate	ADJ
fnp-4366	518	20	immunity	immunity	NOUN
fnp-4366	518	21	)	)	PUNCT
fnp-4366	518	22	was	be	AUX
fnp-4366	518	23	up	up	ADV
fnp-4366	518	24	-	-	PUNCT
fnp-4366	518	25	regulated	regulate	VERB
fnp-4366	518	26	in	in	ADP
fnp-4366	518	27	lopd	lopd	NOUN
fnp-4366	518	28	and	and	CCONJ
fnp-4366	518	29	down	down	ADV
fnp-4366	518	30	-	-	PUNCT
fnp-4366	518	31	regulated	regulate	VERB
fnp-4366	518	32	in	in	ADP
fnp-4366	518	33	iopd	iopd	NOUN
fnp-4366	518	34	whereas	whereas	SCONJ
fnp-4366	518	35	usmg5	usmg5	PROPN
fnp-4366	518	36	(	(	PUNCT
fnp-4366	518	37	upregulated	upregulate	VERB
fnp-4366	518	38	during	during	ADP
fnp-4366	518	39	skeletal	skeletal	ADJ
fnp-4366	518	40	muscle	muscle	NOUN
fnp-4366	518	41	growth	growth	NOUN
fnp-4366	518	42	)	)	PUNCT
fnp-4366	518	43	was	be	AUX
fnp-4366	518	44	upregulated	upregulate	VERB
fnp-4366	518	45	only	only	ADV
fnp-4366	518	46	in	in	ADP
fnp-4366	518	47	iopd	iopd	NOUN
fnp-4366	518	48	.	.	PUNCT
fnp-4366	519	1	the	the	DET
fnp-4366	519	2	gsea	gsea	NOUN
fnp-4366	519	3	further	far	ADV
fnp-4366	519	4	shows	show	VERB
fnp-4366	519	5	a	a	DET
fnp-4366	519	6	positive	positive	ADJ
fnp-4366	519	7	correlation	correlation	NOUN
fnp-4366	519	8	between	between	ADP
fnp-4366	519	9	lopd	lopd	NOUN
fnp-4366	519	10	and	and	CCONJ
fnp-4366	519	11	juvenile	juvenile	ADJ
fnp-4366	519	12	pompe	pompe	NOUN
fnp-4366	519	13	and	and	CCONJ
fnp-4366	519	14	a	a	DET
fnp-4366	519	15	negative	negative	ADJ
fnp-4366	519	16	correlation	correlation	NOUN
fnp-4366	519	17	between	between	ADP
fnp-4366	519	18	iopd	iopd	NOUN
fnp-4366	519	19	and	and	CCONJ
fnp-4366	519	20	lopd	lopd	NOUN
fnp-4366	519	21	/	/	SYM
fnp-4366	519	22	juvenile	juvenile	ADJ
fnp-4366	519	23	pompe	pompe	NOUN
fnp-4366	519	24	.	.	PUNCT
fnp-4366	520	1	discussion	discussion	NOUN
fnp-4366	520	2	:	:	PUNCT
fnp-4366	520	3	mass	mass	ADJ
fnp-4366	520	4	-	-	PUNCT
fnp-4366	520	5	spectrometry	spectrometry	NOUN
fnp-4366	520	6	analysis	analysis	NOUN
fnp-4366	520	7	showed	show	VERB
fnp-4366	520	8	a	a	DET
fnp-4366	520	9	significant	significant	ADJ
fnp-4366	520	10	altered	alter	VERB
fnp-4366	520	11	regulation	regulation	NOUN
fnp-4366	520	12	in	in	ADP
fnp-4366	520	13	skeletal	skeletal	ADJ
fnp-4366	520	14	muscle	muscle	NOUN
fnp-4366	520	15	samples	sample	NOUN
fnp-4366	520	16	from	from	ADP
fnp-4366	520	17	patients	patient	NOUN
fnp-4366	520	18	with	with	ADP
fnp-4366	520	19	pompe	pompe	PROPN
fnp-4366	520	20	disease	disease	NOUN
fnp-4366	520	21	compared	compare	VERB
fnp-4366	520	22	to	to	ADP
fnp-4366	520	23	controls	control	NOUN
fnp-4366	520	24	.	.	PUNCT
fnp-4366	521	1	interestingly	interestingly	ADV
fnp-4366	521	2	most	most	ADJ
fnp-4366	521	3	of	of	ADP
fnp-4366	521	4	the	the	DET
fnp-4366	521	5	dysregulated	dysregulated	ADJ
fnp-4366	521	6	proteins	protein	NOUN
fnp-4366	521	7	varied	varied	ADJ
fnp-4366	521	8	in	in	ADP
fnp-4366	521	9	iopd	iopd	NOUN
fnp-4366	521	10	and	and	CCONJ
fnp-4366	521	11	lopd	lopd	NOUN
fnp-4366	521	12	subgroup	subgroup	NOUN
fnp-4366	521	13	,	,	PUNCT
fnp-4366	521	14	whereas	whereas	SCONJ
fnp-4366	521	15	the	the	DET
fnp-4366	521	16	expression	expression	NOUN
fnp-4366	521	17	profiling	profiling	NOUN
fnp-4366	521	18	was	be	AUX
fnp-4366	521	19	similar	similar	ADJ
fnp-4366	521	20	in	in	ADP
fnp-4366	521	21	the	the	DET
fnp-4366	521	22	juvenile	juvenile	ADJ
fnp-4366	521	23	patients	patient	NOUN
fnp-4366	521	24	compared	compare	VERB
fnp-4366	521	25	to	to	ADP
fnp-4366	521	26	lopd	lopd	VERB
fnp-4366	521	27	.	.	PUNCT
fnp-4366	522	1	these	these	DET
fnp-4366	522	2	data	datum	NOUN
fnp-4366	522	3	underline	underline	VERB
fnp-4366	522	4	the	the	DET
fnp-4366	522	5	heterogeneity	heterogeneity	NOUN
fnp-4366	522	6	in	in	ADP
fnp-4366	522	7	pompe	pompe	PROPN
fnp-4366	522	8	disease	disease	NOUN
fnp-4366	522	9	and	and	CCONJ
fnp-4366	522	10	may	may	AUX
fnp-4366	522	11	indicate	indicate	VERB
fnp-4366	522	12	a	a	DET
fnp-4366	522	13	divergent	divergent	ADJ
fnp-4366	522	14	underlying	underlying	ADJ
fnp-4366	522	15	muscle	muscle	NOUN
fnp-4366	522	16	pathology	pathology	NOUN
fnp-4366	522	17	in	in	ADP
fnp-4366	522	18	infantile	infantile	ADJ
fnp-4366	522	19	patients	patient	NOUN
fnp-4366	522	20	with	with	ADP
fnp-4366	522	21	more	more	ADV
fnp-4366	522	22	immature	immature	ADJ
fnp-4366	522	23	skeletal	skeletal	ADJ
fnp-4366	522	24	muscle	muscle	NOUN
fnp-4366	522	25	fibers	fiber	NOUN
fnp-4366	522	26	compared	compare	VERB
fnp-4366	522	27	to	to	ADP
fnp-4366	522	28	juvenile	juvenile	ADJ
fnp-4366	522	29	and	and	CCONJ
fnp-4366	522	30	adult	adult	NOUN
fnp-4366	522	31	patients	patient	NOUN
fnp-4366	522	32	.	.	PUNCT
fnp-4366	522	33	  	  	SPACE
fnp-4366	523	1	5.02	5.02	NUM
fnp-4366	523	2	free	free	ADJ
fnp-4366	523	3	neuropathol	neuropathol	NOUN
fnp-4366	523	4	3:20:50	3:20:50	NUM
fnp-4366	523	5	expression	expression	NOUN
fnp-4366	523	6	of	of	ADP
fnp-4366	523	7	immune	immune	ADJ
fnp-4366	523	8	regulating	regulate	VERB
fnp-4366	523	9	proteins	protein	NOUN
fnp-4366	523	10	in	in	ADP
fnp-4366	523	11	skeletal	skeletal	ADJ
fnp-4366	523	12	muscle	muscle	NOUN
fnp-4366	523	13	of	of	ADP
fnp-4366	523	14	different	different	ADJ
fnp-4366	523	15	idiopathic	idiopathic	ADJ
fnp-4366	523	16	inflammatory	inflammatory	ADJ
fnp-4366	523	17	myopathies	myopathy	NOUN
fnp-4366	523	18	(	(	PUNCT
fnp-4366	523	19	iim	iim	NOUN
fnp-4366	523	20	)	)	PUNCT
fnp-4366	523	21	subtypes	subtype	NOUN
fnp-4366	523	22	anna	anna	PROPN
fnp-4366	523	23	nishimura1	nishimura1	PROPN
fnp-4366	523	24	,	,	PUNCT
fnp-4366	523	25	rebecca	rebecca	PROPN
fnp-4366	523	26	hasseli2,3	hasseli2,3	PROPN
fnp-4366	523	27	,	,	PUNCT
fnp-4366	523	28	heidrun	heidrun	PROPN
fnp-4366	523	29	h.	h.	PROPN
fnp-4366	523	30	krämer4	krämer4	PROPN
fnp-4366	523	31	,	,	PUNCT
fnp-4366	523	32	angela	angela	PROPN
fnp-4366	523	33	roth1	roth1	PROPN
fnp-4366	523	34	,	,	PUNCT
fnp-4366	523	35	eva	eva	PROPN
fnp-4366	523	36	neuen	neuen	PROPN
fnp-4366	523	37	-	-	PUNCT
fnp-4366	523	38	jacob5	jacob5	NOUN
fnp-4366	523	39	,	,	PUNCT
fnp-4366	523	40	tobias	tobias	PROPN
fnp-4366	523	41	ruck6	ruck6	PROPN
fnp-4366	523	42	,	,	PUNCT
fnp-4366	523	43	anne	anne	PROPN
fnp-4366	523	44	schänzer1	schänzer1	PROPN
fnp-4366	523	45	1	1	NUM
fnp-4366	523	46	institute	institute	NOUN
fnp-4366	523	47	of	of	ADP
fnp-4366	523	48	neuropathology	neuropathology	NOUN
fnp-4366	523	49	,	,	PUNCT
fnp-4366	523	50	justus	justus	PROPN
fnp-4366	523	51	-	-	PUNCT
fnp-4366	523	52	liebig	liebig	NOUN
fnp-4366	523	53	-	-	PUNCT
fnp-4366	523	54	university	university	NOUN
fnp-4366	523	55	,	,	PUNCT
fnp-4366	523	56	giessen	giessen	VERB
fnp-4366	523	57	,	,	PUNCT
fnp-4366	523	58	deutschland	deutschland	NOUN
fnp-4366	523	59	2	2	NUM
fnp-4366	523	60	department	department	NOUN
fnp-4366	523	61	of	of	ADP
fnp-4366	523	62	rheumatology	rheumatology	NOUN
fnp-4366	523	63	and	and	CCONJ
fnp-4366	523	64	clinical	clinical	ADJ
fnp-4366	523	65	immunology	immunology	NOUN
fnp-4366	523	66	,	,	PUNCT
fnp-4366	523	67	campus	campus	NOUN
fnp-4366	523	68	kerckhoff	kerckhoff	NOUN
fnp-4366	523	69	,	,	PUNCT
fnp-4366	523	70	justus	justus	PROPN
fnp-4366	523	71	-	-	PUNCT
fnp-4366	523	72	liebig	liebig	NOUN
fnp-4366	523	73	-	-	PUNCT
fnp-4366	523	74	university	university	NOUN
fnp-4366	523	75	,	,	PUNCT
fnp-4366	523	76	giessen	giessen	VERB
fnp-4366	523	77	,	,	PUNCT
fnp-4366	523	78	deutschland	deutschland	NOUN
fnp-4366	523	79	3	3	NUM
fnp-4366	523	80	department	department	NOUN
fnp-4366	523	81	of	of	ADP
fnp-4366	523	82	internal	internal	PROPN
fnp-4366	523	83	medicine	medicine	PROPN
fnp-4366	523	84	ii	ii	PROPN
fnp-4366	523	85	,	,	PUNCT
fnp-4366	523	86	justus	justus	PROPN
fnp-4366	523	87	-	-	PUNCT
fnp-4366	523	88	liebig	liebig	NOUN
fnp-4366	523	89	-	-	PUNCT
fnp-4366	523	90	university	university	NOUN
fnp-4366	523	91	,	,	PUNCT
fnp-4366	523	92	giessen	giessen	VERB
fnp-4366	523	93	,	,	PUNCT
fnp-4366	523	94	deutschland	deutschland	NOUN
fnp-4366	523	95	4	4	NUM
fnp-4366	523	96	department	department	NOUN
fnp-4366	523	97	of	of	ADP
fnp-4366	523	98	neurology	neurology	NOUN
fnp-4366	523	99	,	,	PUNCT
fnp-4366	523	100	justus	justus	PROPN
fnp-4366	523	101	-	-	PUNCT
fnp-4366	523	102	liebig	liebig	NOUN
fnp-4366	523	103	-	-	PUNCT
fnp-4366	523	104	university	university	NOUN
fnp-4366	523	105	,	,	PUNCT
fnp-4366	523	106	giessen	giessen	VERB
fnp-4366	523	107	,	,	PUNCT
fnp-4366	523	108	deutschland	deutschland	NOUN
fnp-4366	523	109	5	5	NUM
fnp-4366	523	110	institute	institute	NOUN
fnp-4366	523	111	of	of	ADP
fnp-4366	523	112	neuropathology	neuropathology	NOUN
fnp-4366	523	113	,	,	PUNCT
fnp-4366	523	114	heinrich	heinrich	PROPN
fnp-4366	523	115	-	-	PUNCT
fnp-4366	523	116	heine	heine	PROPN
fnp-4366	523	117	-	-	PUNCT
fnp-4366	523	118	university	university	NOUN
fnp-4366	523	119	,	,	PUNCT
fnp-4366	523	120	düsseldorf	düsseldorf	PROPN
fnp-4366	523	121	,	,	PUNCT
fnp-4366	523	122	deutschland	deutschland	NOUN
fnp-4366	523	123	6	6	NUM
fnp-4366	523	124	department	department	NOUN
fnp-4366	523	125	of	of	ADP
fnp-4366	523	126	neurology	neurology	NOUN
fnp-4366	523	127	,	,	PUNCT
fnp-4366	523	128	medical	medical	ADJ
fnp-4366	523	129	faculty	faculty	NOUN
fnp-4366	523	130	,	,	PUNCT
fnp-4366	523	131	heinrich	heinrich	PROPN
fnp-4366	523	132	-	-	PUNCT
fnp-4366	523	133	heine	heine	PROPN
fnp-4366	523	134	-	-	PUNCT
fnp-4366	523	135	university	university	NOUN
fnp-4366	523	136	,	,	PUNCT
fnp-4366	523	137	düsseldorf	düsseldorf	PROPN
fnp-4366	523	138	,	,	PUNCT
fnp-4366	523	139	deutschland	deutschland	NOUN
fnp-4366	523	140	background	background	NOUN
fnp-4366	523	141	:	:	PUNCT
fnp-4366	523	142	idiopathic	idiopathic	ADJ
fnp-4366	523	143	inflammatory	inflammatory	ADJ
fnp-4366	523	144	myopathies	myopathy	NOUN
fnp-4366	523	145	(	(	PUNCT
fnp-4366	523	146	iims	iim	NOUN
fnp-4366	523	147	)	)	PUNCT
fnp-4366	523	148	are	be	AUX
fnp-4366	523	149	autoimmune	autoimmune	ADJ
fnp-4366	523	150	diseases	disease	NOUN
fnp-4366	523	151	classified	classify	VERB
fnp-4366	523	152	as	as	ADP
fnp-4366	523	153	polymyositis	polymyositis	PROPN
fnp-4366	523	154	(	(	PUNCT
fnp-4366	523	155	pm	pm	NOUN
fnp-4366	523	156	)	)	PUNCT
fnp-4366	523	157	,	,	PUNCT
fnp-4366	523	158	dermatomyositis	dermatomyositis	PROPN
fnp-4366	523	159	(	(	PUNCT
fnp-4366	523	160	dm	dm	PROPN
fnp-4366	523	161	)	)	PUNCT
fnp-4366	523	162	,	,	PUNCT
fnp-4366	523	163	immune	immune	NOUN
fnp-4366	523	164	-	-	PUNCT
fnp-4366	523	165	mediated	mediate	VERB
fnp-4366	523	166	necrotizing	necrotizing	NOUN
fnp-4366	523	167	myopathy	myopathy	NOUN
fnp-4366	523	168	(	(	PUNCT
fnp-4366	523	169	imnm	imnm	PROPN
fnp-4366	523	170	)	)	PUNCT
fnp-4366	523	171	,	,	PUNCT
fnp-4366	523	172	anti	anti	ADJ
fnp-4366	523	173	-	-	ADJ
fnp-4366	523	174	synthetase	synthetase	ADJ
fnp-4366	523	175	syndrome	syndrome	NOUN
fnp-4366	523	176	(	(	PUNCT
fnp-4366	523	177	asys	asys	PROPN
fnp-4366	523	178	)	)	PUNCT
fnp-4366	523	179	and	and	CCONJ
fnp-4366	523	180	sporadic	sporadic	ADJ
fnp-4366	523	181	inclusion	inclusion	NOUN
fnp-4366	523	182	body	body	NOUN
fnp-4366	523	183	myositis	myositis	PROPN
fnp-4366	523	184	(	(	PUNCT
fnp-4366	523	185	sibm	sibm	PROPN
fnp-4366	523	186	)	)	PUNCT
fnp-4366	523	187	.	.	PUNCT
fnp-4366	524	1	adaptive	adaptive	ADJ
fnp-4366	524	2	and	and	CCONJ
fnp-4366	524	3	innate	innate	ADJ
fnp-4366	524	4	immune	immune	ADJ
fnp-4366	524	5	responses	response	NOUN
fnp-4366	524	6	play	play	VERB
fnp-4366	524	7	a	a	DET
fnp-4366	524	8	role	role	NOUN
fnp-4366	524	9	in	in	ADP
fnp-4366	524	10	the	the	DET
fnp-4366	524	11	pathogenesis	pathogenesis	NOUN
fnp-4366	524	12	of	of	ADP
fnp-4366	524	13	iim	iim	NOUN
fnp-4366	524	14	and	and	CCONJ
fnp-4366	524	15	immunomodulatory	immunomodulatory	ADJ
fnp-4366	524	16	treatment	treatment	NOUN
fnp-4366	524	17	is	be	AUX
fnp-4366	524	18	the	the	DET
fnp-4366	524	19	recommended	recommend	VERB
fnp-4366	524	20	therapy	therapy	NOUN
fnp-4366	524	21	.	.	PUNCT
fnp-4366	525	1	the	the	DET
fnp-4366	525	2	individual	individual	ADJ
fnp-4366	525	3	regulatory	regulatory	ADJ
fnp-4366	525	4	mechanisms	mechanism	NOUN
fnp-4366	525	5	in	in	ADP
fnp-4366	525	6	iim	iim	NOUN
fnp-4366	525	7	subtypes	subtype	NOUN
fnp-4366	525	8	might	might	AUX
fnp-4366	525	9	differ	differ	VERB
fnp-4366	525	10	and	and	CCONJ
fnp-4366	525	11	a	a	DET
fnp-4366	525	12	better	well	ADJ
fnp-4366	525	13	understanding	understanding	NOUN
fnp-4366	525	14	of	of	ADP
fnp-4366	525	15	the	the	DET
fnp-4366	525	16	pathophysiology	pathophysiology	NOUN
fnp-4366	525	17	would	would	AUX
fnp-4366	525	18	improve	improve	VERB
fnp-4366	525	19	the	the	DET
fnp-4366	525	20	individual	individual	ADJ
fnp-4366	525	21	therapeutic	therapeutic	ADJ
fnp-4366	525	22	approaches	approach	NOUN
fnp-4366	525	23	.	.	PUNCT
fnp-4366	526	1	with	with	ADP
fnp-4366	526	2	whole	whole	ADJ
fnp-4366	526	3	muscle	muscle	NOUN
fnp-4366	526	4	section	section	NOUN
fnp-4366	526	5	morphometry	morphometry	NOUN
fnp-4366	526	6	,	,	PUNCT
fnp-4366	526	7	we	we	PRON
fnp-4366	526	8	want	want	VERB
fnp-4366	526	9	to	to	PART
fnp-4366	526	10	analyze	analyze	VERB
fnp-4366	526	11	the	the	DET
fnp-4366	526	12	immune	immune	ADJ
fnp-4366	526	13	regulating	regulate	VERB
fnp-4366	526	14	proteins	protein	NOUN
fnp-4366	526	15	in	in	ADP
fnp-4366	526	16	certain	certain	ADJ
fnp-4366	526	17	subtypes	subtype	NOUN
fnp-4366	526	18	of	of	ADP
fnp-4366	526	19	iim	iim	NOUN
fnp-4366	526	20	.	.	PUNCT
fnp-4366	527	1	methods	method	NOUN
fnp-4366	527	2	:	:	PUNCT
fnp-4366	527	3	muscle	muscle	NOUN
fnp-4366	527	4	biopsies	biopsy	NOUN
fnp-4366	527	5	from	from	ADP
fnp-4366	527	6	24	24	NUM
fnp-4366	527	7	adult	adult	NOUN
fnp-4366	527	8	patients	patient	NOUN
fnp-4366	527	9	with	with	ADP
fnp-4366	527	10	iim	iim	NOUN
fnp-4366	527	11	(	(	PUNCT
fnp-4366	527	12	average	average	ADJ
fnp-4366	527	13	age	age	NOUN
fnp-4366	527	14	at	at	ADP
fnp-4366	527	15	biopsy	biopsy	NOUN
fnp-4366	527	16	54.6	54.6	NUM
fnp-4366	527	17	years	year	NOUN
fnp-4366	527	18	;	;	PUNCT
fnp-4366	527	19	65.2	65.2	NUM
fnp-4366	527	20	%	%	NOUN
fnp-4366	527	21	female	female	NOUN
fnp-4366	527	22	;	;	PUNCT
fnp-4366	527	23	dm	dm	PROPN
fnp-4366	527	24	n=5	n=5	NUM
fnp-4366	527	25	;	;	PUNCT
fnp-4366	527	26	imnm	imnm	PROPN
fnp-4366	527	27	n=5	n=5	PROPN
fnp-4366	527	28	;	;	PUNCT
fnp-4366	527	29	asys	asys	PROPN
fnp-4366	527	30	n=7	n=7	PROPN
fnp-4366	527	31	;	;	PUNCT
fnp-4366	527	32	sibm	sibm	PROPN
fnp-4366	527	33	n=7	n=7	PROPN
fnp-4366	527	34	)	)	PUNCT
fnp-4366	527	35	,	,	PUNCT
fnp-4366	527	36	neurogenic	neurogenic	ADJ
fnp-4366	527	37	atrophy	atrophy	NOUN
fnp-4366	527	38	(	(	PUNCT
fnp-4366	527	39	na	na	NOUN
fnp-4366	527	40	;	;	PUNCT
fnp-4366	527	41	n=4	n=4	X
fnp-4366	527	42	)	)	PUNCT
fnp-4366	527	43	and	and	CCONJ
fnp-4366	527	44	controls	control	NOUN
fnp-4366	527	45	(	(	PUNCT
fnp-4366	527	46	hc	hc	NOUN
fnp-4366	527	47	;	;	PUNCT
fnp-4366	527	48	n=6	n=6	NUM
fnp-4366	527	49	)	)	PUNCT
fnp-4366	527	50	were	be	AUX
fnp-4366	527	51	included	include	VERB
fnp-4366	527	52	in	in	ADP
fnp-4366	527	53	the	the	DET
fnp-4366	527	54	study	study	NOUN
fnp-4366	527	55	.	.	PUNCT
fnp-4366	528	1	all	all	DET
fnp-4366	528	2	biopsies	biopsy	NOUN
fnp-4366	528	3	were	be	AUX
fnp-4366	528	4	re	re	VERB
fnp-4366	528	5	-	-	VERB
fnp-4366	528	6	evaluated	evaluate	VERB
fnp-4366	528	7	according	accord	VERB
fnp-4366	528	8	to	to	ADP
fnp-4366	528	9	the	the	DET
fnp-4366	528	10	common	common	ADJ
fnp-4366	528	11	classification	classification	NOUN
fnp-4366	528	12	.	.	PUNCT
fnp-4366	529	1	the	the	DET
fnp-4366	529	2	degree	degree	NOUN
fnp-4366	529	3	of	of	ADP
fnp-4366	529	4	pathology	pathology	NOUN
fnp-4366	529	5	severity	severity	NOUN
fnp-4366	529	6	was	be	AUX
fnp-4366	529	7	estimated	estimate	VERB
fnp-4366	529	8	using	use	VERB
fnp-4366	529	9	a	a	DET
fnp-4366	529	10	semiquantitative	semiquantitative	ADJ
fnp-4366	529	11	pathology	pathology	NOUN
fnp-4366	529	12	score	score	NOUN
fnp-4366	529	13	(	(	PUNCT
fnp-4366	529	14	p	p	NOUN
fnp-4366	529	15	-	-	PUNCT
fnp-4366	529	16	score	score	NOUN
fnp-4366	529	17	from	from	ADP
fnp-4366	529	18	0	0	NUM
fnp-4366	529	19	to	to	ADP
fnp-4366	529	20	10	10	NUM
fnp-4366	529	21	)	)	PUNCT
fnp-4366	529	22	.	.	PUNCT
fnp-4366	530	1	double	double	ADJ
fnp-4366	530	2	immunofluorescence	immunofluorescence	NOUN
fnp-4366	530	3	staining	stain	VERB
fnp-4366	530	4	was	be	AUX
fnp-4366	530	5	performed	perform	VERB
fnp-4366	530	6	with	with	ADP
fnp-4366	530	7	antibodies	antibody	NOUN
fnp-4366	530	8	against	against	ADP
fnp-4366	530	9	mhc-1	mhc-1	NOUN
fnp-4366	530	10	(	(	PUNCT
fnp-4366	530	11	major	major	ADJ
fnp-4366	530	12	histocompatibility	histocompatibility	NOUN
fnp-4366	530	13	complex	complex	ADJ
fnp-4366	530	14	1	1	NUM
fnp-4366	530	15	)	)	PUNCT
fnp-4366	530	16	,	,	PUNCT
fnp-4366	530	17	mhc-2	mhc-2	PRON
fnp-4366	530	18	,	,	PUNCT
fnp-4366	530	19	icam-1	icam-1	NUM
fnp-4366	530	20	(	(	PUNCT
fnp-4366	530	21	intercellular	intercellular	ADJ
fnp-4366	530	22	adhesion	adhesion	NOUN
fnp-4366	530	23	molecule	molecule	NOUN
fnp-4366	530	24	1	1	NUM
fnp-4366	530	25	)	)	PUNCT
fnp-4366	530	26	and	and	CCONJ
fnp-4366	530	27	vcam-1	vcam-1	NUM
fnp-4366	530	28	(	(	PUNCT
fnp-4366	530	29	vascular	vascular	ADJ
fnp-4366	530	30	cell	cell	NOUN
fnp-4366	530	31	adhesion	adhesion	NOUN
fnp-4366	530	32	molecule	molecule	NOUN
fnp-4366	530	33	1	1	NUM
fnp-4366	530	34	)	)	PUNCT
fnp-4366	530	35	and	and	CCONJ
fnp-4366	530	36	antibodies	antibodie	VERB
fnp-4366	530	37	against	against	ADP
fnp-4366	530	38	spectrin	spectrin	NOUN
fnp-4366	530	39	or	or	CCONJ
fnp-4366	530	40	desmin	desmin	NOUN
fnp-4366	530	41	.	.	PUNCT
fnp-4366	531	1	the	the	DET
fnp-4366	531	2	sections	section	NOUN
fnp-4366	531	3	were	be	AUX
fnp-4366	531	4	subsequently	subsequently	ADV
fnp-4366	531	5	digitalized	digitalize	VERB
fnp-4366	531	6	using	use	VERB
fnp-4366	531	7	a	a	DET
fnp-4366	531	8	zeiss	zeiss	PROPN
fnp-4366	531	9	axio	axio	PROPN
fnp-4366	531	10	scan.z1	scan.z1	PROPN
fnp-4366	531	11	slide	slide	NOUN
fnp-4366	531	12	scanner	scanner	NOUN
fnp-4366	531	13	.	.	PUNCT
fnp-4366	532	1	the	the	DET
fnp-4366	532	2	coexpression	coexpression	NOUN
fnp-4366	532	3	was	be	AUX
fnp-4366	532	4	analyzed	analyze	VERB
fnp-4366	532	5	on	on	ADP
fnp-4366	532	6	entire	entire	ADJ
fnp-4366	532	7	sections	section	NOUN
fnp-4366	532	8	using	use	VERB
fnp-4366	532	9	imagej	imagej	ADJ
fnp-4366	532	10	software	software	NOUN
fnp-4366	532	11	and	and	CCONJ
fnp-4366	532	12	quantified	quantify	VERB
fnp-4366	532	13	using	use	VERB
fnp-4366	532	14	the	the	DET
fnp-4366	532	15	manders	mander	NOUN
fnp-4366	532	16	'	'	PART
fnp-4366	532	17	coefficient	coefficient	NOUN
fnp-4366	532	18	(	(	PUNCT
fnp-4366	532	19	m	m	NOUN
fnp-4366	532	20	)	)	PUNCT
fnp-4366	532	21	.	.	PUNCT
fnp-4366	533	1	results	result	NOUN
fnp-4366	533	2	:	:	PUNCT
fnp-4366	533	3	mhc-1	mhc-1	NUM
fnp-4366	533	4	expression	expression	NOUN
fnp-4366	533	5	was	be	AUX
fnp-4366	533	6	significantly	significantly	ADV
fnp-4366	533	7	upregulated	upregulate	VERB
fnp-4366	533	8	on	on	ADP
fnp-4366	533	9	muscle	muscle	NOUN
fnp-4366	533	10	fibers	fiber	NOUN
fnp-4366	533	11	of	of	ADP
fnp-4366	533	12	patients	patient	NOUN
fnp-4366	533	13	with	with	ADP
fnp-4366	533	14	asys	asys	NOUN
fnp-4366	533	15	(	(	PUNCT
fnp-4366	533	16	m=0.559	m=0.559	NOUN
fnp-4366	533	17	)	)	PUNCT
fnp-4366	533	18	,	,	PUNCT
fnp-4366	533	19	dm	dm	PROPN
fnp-4366	533	20	(	(	PUNCT
fnp-4366	533	21	m=0.609	m=0.609	PROPN
fnp-4366	533	22	)	)	PUNCT
fnp-4366	533	23	,	,	PUNCT
fnp-4366	533	24	sibm	sibm	NOUN
fnp-4366	533	25	(	(	PUNCT
fnp-4366	533	26	m=0.557	m=0.557	PROPN
fnp-4366	533	27	)	)	PUNCT
fnp-4366	533	28	and	and	CCONJ
fnp-4366	533	29	na	na	INTJ
fnp-4366	533	30	(	(	PUNCT
fnp-4366	533	31	m=0.208	m=0.208	X
fnp-4366	533	32	)	)	PUNCT
fnp-4366	533	33	compared	compare	VERB
fnp-4366	533	34	to	to	ADP
fnp-4366	533	35	hc	hc	PROPN
fnp-4366	533	36	(	(	PUNCT
fnp-4366	533	37	m=0.009	m=0.009	NOUN
fnp-4366	533	38	)	)	PUNCT
fnp-4366	533	39	.	.	PUNCT
fnp-4366	534	1	for	for	ADP
fnp-4366	534	2	imnm	imnm	PROPN
fnp-4366	534	3	(	(	PUNCT
fnp-4366	534	4	m=0.079	m=0.079	PROPN
fnp-4366	534	5	)	)	PUNCT
fnp-4366	534	6	,	,	PUNCT
fnp-4366	534	7	the	the	DET
fnp-4366	534	8	expression	expression	NOUN
fnp-4366	534	9	was	be	AUX
fnp-4366	534	10	significantly	significantly	ADV
fnp-4366	534	11	lower	low	ADJ
fnp-4366	534	12	compared	compare	VERB
fnp-4366	534	13	to	to	ADP
fnp-4366	534	14	asys	asys	NOUN
fnp-4366	534	15	and	and	CCONJ
fnp-4366	534	16	dm	dm	NOUN
fnp-4366	534	17	.	.	PUNCT
fnp-4366	535	1	significant	significant	ADJ
fnp-4366	535	2	upregulations	upregulation	NOUN
fnp-4366	535	3	of	of	ADP
fnp-4366	535	4	mhc-2	mhc-2	PUNCT
fnp-4366	535	5	were	be	AUX
fnp-4366	535	6	found	find	VERB
fnp-4366	535	7	for	for	ADP
fnp-4366	535	8	asys	asys	NOUN
fnp-4366	535	9	(	(	PUNCT
fnp-4366	535	10	m=0.263	m=0.263	NUM
fnp-4366	535	11	)	)	PUNCT
fnp-4366	535	12	,	,	PUNCT
fnp-4366	535	13	dm	dm	PROPN
fnp-4366	535	14	(	(	PUNCT
fnp-4366	535	15	m=0.504	m=0.504	NUM
fnp-4366	535	16	)	)	PUNCT
fnp-4366	535	17	,	,	PUNCT
fnp-4366	535	18	sibm	sibm	NOUN
fnp-4366	535	19	(	(	PUNCT
fnp-4366	535	20	m=0.336	m=0.336	PROPN
fnp-4366	535	21	)	)	PUNCT
fnp-4366	535	22	and	and	CCONJ
fnp-4366	535	23	na	na	INTJ
fnp-4366	535	24	(	(	PUNCT
fnp-4366	535	25	m=0.416	m=0.416	NOUN
fnp-4366	535	26	)	)	PUNCT
fnp-4366	535	27	compared	compare	VERB
fnp-4366	535	28	to	to	ADP
fnp-4366	535	29	hc	hc	PROPN
fnp-4366	535	30	(	(	PUNCT
fnp-4366	535	31	m=0.036	m=0.036	NOUN
fnp-4366	535	32	)	)	PUNCT
fnp-4366	535	33	,	,	PUNCT
fnp-4366	535	34	as	as	ADV
fnp-4366	535	35	well	well	ADV
fnp-4366	535	36	as	as	ADP
fnp-4366	535	37	a	a	DET
fnp-4366	535	38	significant	significant	ADJ
fnp-4366	535	39	upregulation	upregulation	NOUN
fnp-4366	535	40	for	for	ADP
fnp-4366	535	41	dm	dm	PRON
fnp-4366	535	42	compared	compare	VERB
fnp-4366	535	43	to	to	ADP
fnp-4366	535	44	imnm	imnm	PROPN
fnp-4366	535	45	(	(	PUNCT
fnp-4366	535	46	m=0.055	m=0.055	NOUN
fnp-4366	535	47	)	)	PUNCT
fnp-4366	535	48	.	.	PUNCT
fnp-4366	536	1	only	only	ADV
fnp-4366	536	2	asys	asys	NOUN
fnp-4366	536	3	samples	sample	NOUN
fnp-4366	536	4	showed	show	VERB
fnp-4366	536	5	a	a	DET
fnp-4366	536	6	significant	significant	ADJ
fnp-4366	536	7	upregulation	upregulation	NOUN
fnp-4366	536	8	of	of	ADP
fnp-4366	536	9	icam-1	icam-1	NUM
fnp-4366	536	10	compared	compare	VERB
fnp-4366	536	11	to	to	ADP
fnp-4366	536	12	hc	hc	PROPN
fnp-4366	536	13	(	(	PUNCT
fnp-4366	536	14	m=0.060	m=0.060	NOUN
fnp-4366	536	15	)	)	PUNCT
fnp-4366	536	16	,	,	PUNCT
fnp-4366	536	17	whereas	whereas	SCONJ
fnp-4366	536	18	in	in	ADP
fnp-4366	536	19	general	general	ADJ
fnp-4366	536	20	,	,	PUNCT
fnp-4366	536	21	the	the	DET
fnp-4366	536	22	expression	expression	NOUN
fnp-4366	536	23	varied	vary	VERB
fnp-4366	536	24	strongly	strongly	ADV
fnp-4366	536	25	(	(	PUNCT
fnp-4366	536	26	asys	asys	PROPN
fnp-4366	536	27	m=0.263±0.182	m=0.263±0.182	NOUN
fnp-4366	536	28	;	;	PUNCT
fnp-4366	536	29	dm	dm	PROPN
fnp-4366	536	30	m=0.270±0.256	m=0.270±0.256	X
fnp-4366	536	31	;	;	PUNCT
fnp-4366	536	32	sibm	sibm	PROPN
fnp-4366	536	33	m=0.337±0.249	m=0.337±0.249	PROPN
fnp-4366	536	34	;	;	PUNCT
fnp-4366	536	35	imnm	imnm	PROPN
fnp-4366	536	36	m=0.335±0.295	m=0.335±0.295	NOUN
fnp-4366	536	37	)	)	PUNCT
fnp-4366	536	38	with	with	ADP
fnp-4366	536	39	no	no	DET
fnp-4366	536	40	significant	significant	ADJ
fnp-4366	536	41	difference	difference	NOUN
fnp-4366	536	42	between	between	ADP
fnp-4366	536	43	the	the	DET
fnp-4366	536	44	iim	iim	PROPN
fnp-4366	536	45	subtypes	subtype	NOUN
fnp-4366	536	46	.	.	PUNCT
fnp-4366	537	1	vcam-1	vcam-1	NOUN
fnp-4366	537	2	expression	expression	NOUN
fnp-4366	537	3	showed	show	VERB
fnp-4366	537	4	no	no	DET
fnp-4366	537	5	significant	significant	ADJ
fnp-4366	537	6	difference	difference	NOUN
fnp-4366	537	7	between	between	ADP
fnp-4366	537	8	the	the	DET
fnp-4366	537	9	iim	iim	PROPN
fnp-4366	537	10	subtypes	subtype	NOUN
fnp-4366	537	11	.	.	PUNCT
fnp-4366	538	1	however	however	ADV
fnp-4366	538	2	,	,	PUNCT
fnp-4366	538	3	in	in	ADP
fnp-4366	538	4	comparison	comparison	NOUN
fnp-4366	538	5	to	to	ADP
fnp-4366	538	6	hc	hc	PROPN
fnp-4366	538	7	(	(	PUNCT
fnp-4366	538	8	m=0.036	m=0.036	NOUN
fnp-4366	538	9	)	)	PUNCT
fnp-4366	538	10	we	we	PRON
fnp-4366	538	11	found	find	VERB
fnp-4366	538	12	vcam-1	vcam-1	NOUN
fnp-4366	538	13	significantly	significantly	ADV
fnp-4366	538	14	upregulated	upregulate	VERB
fnp-4366	538	15	in	in	ADP
fnp-4366	538	16	asys	asys	NOUN
fnp-4366	538	17	(	(	PUNCT
fnp-4366	538	18	m=0.200	m=0.200	NUM
fnp-4366	538	19	)	)	PUNCT
fnp-4366	538	20	,	,	PUNCT
fnp-4366	538	21	dm	dm	X
fnp-4366	538	22	(	(	PUNCT
fnp-4366	538	23	m=0.377	m=0.377	NOUN
fnp-4366	538	24	)	)	PUNCT
fnp-4366	538	25	and	and	CCONJ
fnp-4366	538	26	sibm	sibm	NOUN
fnp-4366	538	27	(	(	PUNCT
fnp-4366	538	28	m=0.371	m=0.371	NUM
fnp-4366	538	29	)	)	PUNCT
fnp-4366	538	30	.	.	PUNCT
fnp-4366	539	1	correlating	correlate	VERB
fnp-4366	539	2	our	our	PRON
fnp-4366	539	3	results	result	NOUN
fnp-4366	539	4	with	with	ADP
fnp-4366	539	5	the	the	DET
fnp-4366	539	6	p	p	NOUN
fnp-4366	539	7	-	-	PUNCT
fnp-4366	539	8	score	score	NOUN
fnp-4366	539	9	,	,	PUNCT
fnp-4366	539	10	a	a	DET
fnp-4366	539	11	positive	positive	ADJ
fnp-4366	539	12	correlation	correlation	NOUN
fnp-4366	539	13	(	(	PUNCT
fnp-4366	539	14	r=0.770	r=0.770	NOUN
fnp-4366	539	15	)	)	PUNCT
fnp-4366	539	16	for	for	ADP
fnp-4366	539	17	icam-1	icam-1	NUM
fnp-4366	539	18	expression	expression	NOUN
fnp-4366	539	19	in	in	ADP
fnp-4366	539	20	sibm	sibm	NOUN
fnp-4366	539	21	was	be	AUX
fnp-4366	539	22	found	find	VERB
fnp-4366	539	23	.	.	PUNCT
fnp-4366	540	1	conclusion	conclusion	NOUN
fnp-4366	540	2	:	:	PUNCT
fnp-4366	540	3	we	we	PRON
fnp-4366	540	4	analyzed	analyze	VERB
fnp-4366	540	5	protein	protein	NOUN
fnp-4366	540	6	expression	expression	NOUN
fnp-4366	540	7	levels	level	NOUN
fnp-4366	540	8	on	on	ADP
fnp-4366	540	9	muscle	muscle	NOUN
fnp-4366	540	10	fibers	fiber	NOUN
fnp-4366	540	11	in	in	ADP
fnp-4366	540	12	whole	whole	ADJ
fnp-4366	540	13	section	section	NOUN
fnp-4366	540	14	analysis	analysis	NOUN
fnp-4366	540	15	,	,	PUNCT
fnp-4366	540	16	which	which	PRON
fnp-4366	540	17	provides	provide	VERB
fnp-4366	540	18	accurate	accurate	ADJ
fnp-4366	540	19	data	datum	NOUN
fnp-4366	540	20	on	on	ADP
fnp-4366	540	21	larger	large	ADJ
fnp-4366	540	22	sections	section	NOUN
fnp-4366	540	23	.	.	PUNCT
fnp-4366	541	1	different	different	ADJ
fnp-4366	541	2	expression	expression	NOUN
fnp-4366	541	3	patterns	pattern	NOUN
fnp-4366	541	4	of	of	ADP
fnp-4366	541	5	mhc-1/2	mhc-1/2	PROPN
fnp-4366	541	6	,	,	PUNCT
fnp-4366	541	7	icam-1	icam-1	NUM
fnp-4366	541	8	and	and	CCONJ
fnp-4366	541	9	vcam-1	vcam-1	NUM
fnp-4366	541	10	were	be	AUX
fnp-4366	541	11	found	find	VERB
fnp-4366	541	12	in	in	ADP
fnp-4366	541	13	iim	iim	NOUN
fnp-4366	541	14	subtypes	subtype	NOUN
fnp-4366	541	15	with	with	ADP
fnp-4366	541	16	lower	low	ADJ
fnp-4366	541	17	expressions	expression	NOUN
fnp-4366	541	18	in	in	ADP
fnp-4366	541	19	imnm	imnm	NOUN
fnp-4366	541	20	for	for	ADP
fnp-4366	541	21	mhc-1/2	mhc-1/2	PROPN
fnp-4366	541	22	and	and	CCONJ
fnp-4366	541	23	vcam-1	vcam-1	NUM
fnp-4366	541	24	.	.	PROPN
fnp-4366	542	1	interestingly	interestingly	ADV
fnp-4366	542	2	,	,	PUNCT
fnp-4366	542	3	in	in	ADP
fnp-4366	542	4	sibm	sibm	NOUN
fnp-4366	542	5	icam-1	icam-1	NUM
fnp-4366	542	6	expression	expression	NOUN
fnp-4366	542	7	correlated	correlate	VERB
fnp-4366	542	8	with	with	ADP
fnp-4366	542	9	the	the	DET
fnp-4366	542	10	pathology	pathology	NOUN
fnp-4366	542	11	score	score	NOUN
fnp-4366	542	12	.	.	PUNCT
fnp-4366	543	1	these	these	DET
fnp-4366	543	2	insights	insight	NOUN
fnp-4366	543	3	might	might	AUX
fnp-4366	543	4	help	help	VERB
fnp-4366	543	5	to	to	PART
fnp-4366	543	6	improve	improve	VERB
fnp-4366	543	7	morphological	morphological	ADJ
fnp-4366	543	8	diagnosis	diagnosis	NOUN
fnp-4366	543	9	in	in	ADP
fnp-4366	543	10	iim	iim	NOUN
fnp-4366	543	11	subtypes	subtype	NOUN
fnp-4366	543	12	and	and	CCONJ
fnp-4366	543	13	identify	identify	VERB
fnp-4366	543	14	individual	individual	ADJ
fnp-4366	543	15	immune	immune	ADJ
fnp-4366	543	16	response	response	NOUN
fnp-4366	543	17	patterns	pattern	NOUN
fnp-4366	543	18	,	,	PUNCT
fnp-4366	543	19	which	which	PRON
fnp-4366	543	20	may	may	AUX
fnp-4366	543	21	improve	improve	VERB
fnp-4366	543	22	the	the	DET
fnp-4366	543	23	accuracy	accuracy	NOUN
fnp-4366	543	24	of	of	ADP
fnp-4366	543	25	future	future	ADJ
fnp-4366	543	26	diagnoses	diagnosis	NOUN
fnp-4366	543	27	.	.	PUNCT
fnp-4366	543	28	  	  	SPACE
fnp-4366	544	1	5.03	5.03	NUM
fnp-4366	544	2	free	free	ADJ
fnp-4366	544	3	neuropathol	neuropathol	NOUN
fnp-4366	544	4	3:20:52	3:20:52	NUM
fnp-4366	544	5	long	long	ADJ
fnp-4366	544	6	term	term	NOUN
fnp-4366	544	7	safety	safety	NOUN
fnp-4366	544	8	and	and	CCONJ
fnp-4366	544	9	efficacy	efficacy	NOUN
fnp-4366	544	10	outcomes	outcome	NOUN
fnp-4366	544	11	for	for	ADP
fnp-4366	544	12	x	x	VERB
fnp-4366	544	13	-	-	VERB
fnp-4366	544	14	linked	link	VERB
fnp-4366	544	15	myotubular	myotubular	ADJ
fnp-4366	544	16	myopathy	myopathy	ADJ
fnp-4366	544	17	(	(	PUNCT
fnp-4366	544	18	xlmtm	xlmtm	PROPN
fnp-4366	544	19	)	)	PUNCT
fnp-4366	544	20	with	with	ADP
fnp-4366	544	21	gene	gene	NOUN
fnp-4366	544	22	replacement	replacement	NOUN
fnp-4366	544	23	therapy	therapy	NOUN
fnp-4366	544	24	,	,	PUNCT
fnp-4366	544	25	resamirigene	resamirigene	NOUN
fnp-4366	544	26	bilparvovec	bilparvovec	PROPN
fnp-4366	544	27	(	(	PUNCT
fnp-4366	544	28	aspiro	aspiro	ADJ
fnp-4366	544	29	):	):	PUNCT
fnp-4366	544	30	preliminary	preliminary	ADJ
fnp-4366	544	31	results	result	NOUN
fnp-4366	544	32	from	from	ADP
fnp-4366	544	33	cohort	cohort	NOUN
fnp-4366	544	34	1	1	NUM
fnp-4366	544	35	in	in	ADP
fnp-4366	544	36	aspiro	aspiro	ADJ
fnp-4366	544	37	,	,	PUNCT
fnp-4366	544	38	a	a	DET
fnp-4366	544	39	phase	phase	NOUN
fnp-4366	544	40	1/2/3	1/2/3	NUM
fnp-4366	544	41	study	study	NOUN
fnp-4366	544	42	astrid	astrid	PROPN
fnp-4366	544	43	blaschek1	blaschek1	PROPN
fnp-4366	544	44	,	,	PUNCT
fnp-4366	544	45	perry	perry	PROPN
fnp-4366	544	46	shieh2	shieh2	PROPN
fnp-4366	544	47	,	,	PUNCT
fnp-4366	544	48	nancy	nancy	PROPN
fnp-4366	544	49	kuntz3	kuntz3	PROPN
fnp-4366	544	50	,	,	PUNCT
fnp-4366	544	51	james	james	PROPN
fnp-4366	544	52	dowling4	dowling4	PROPN
fnp-4366	544	53	,	,	PUNCT
fnp-4366	544	54	carsten	carsten	PROPN
fnp-4366	544	55	bonnemann5	bonnemann5	PROPN
fnp-4366	544	56	,	,	PUNCT
fnp-4366	544	57	a.	a.	NOUN
fnp-4366	544	58	reghan	reghan	PROPN
fnp-4366	544	59	foley5	foley5	PROPN
fnp-4366	544	60	,	,	PUNCT
fnp-4366	544	61	dimah	dimah	PROPN
fnp-4366	544	62	saade6	saade6	PROPN
fnp-4366	544	63	,	,	PUNCT
fnp-4366	544	64	andreea	andreea	PROPN
fnp-4366	544	65	seferian7	seferian7	PROPN
fnp-4366	544	66	,	,	PUNCT
fnp-4366	544	67	laurent	laurent	NOUN
fnp-4366	544	68	servais8	servais8	PROPN
fnp-4366	544	69	,	,	PUNCT
fnp-4366	544	70	neema	neema	PROPN
fnp-4366	544	71	lakshman9	lakshman9	PROPN
fnp-4366	544	72	,	,	PUNCT
fnp-4366	544	73	cong	cong	VERB
fnp-4366	544	74	han10	han10	PROPN
fnp-4366	544	75	,	,	PUNCT
fnp-4366	544	76	suyash	suyash	ADJ
fnp-4366	544	77	prasad11	prasad11	NOUN
fnp-4366	544	78	,	,	PUNCT
fnp-4366	544	79	salvador	salvador	PROPN
fnp-4366	544	80	rico11	rico11	PROPN
fnp-4366	544	81	,	,	PUNCT
fnp-4366	544	82	westin	westin	PROPN
fnp-4366	544	83	miller9	miller9	PROPN
fnp-4366	544	84	1	1	NUM
fnp-4366	544	85	klinikum	klinikum	NOUN
fnp-4366	544	86	der	der	PROPN
fnp-4366	544	87	universität	universität	PROPN
fnp-4366	544	88	münchen	münchen	NOUN
fnp-4366	544	89	,	,	PUNCT
fnp-4366	544	90	münchen	münchen	NOUN
fnp-4366	544	91	,	,	PUNCT
fnp-4366	544	92	deutschland	deutschland	NOUN
fnp-4366	544	93	2	2	NUM
fnp-4366	544	94	university	university	NOUN
fnp-4366	544	95	of	of	ADP
fnp-4366	544	96	california	california	PROPN
fnp-4366	544	97	,	,	PUNCT
fnp-4366	544	98	los	los	PROPN
fnp-4366	544	99	angeles	angeles	PROPN
fnp-4366	544	100	,	,	PUNCT
fnp-4366	544	101	united	united	PROPN
fnp-4366	544	102	states	states	PROPN
fnp-4366	544	103	3	3	NUM
fnp-4366	544	104	ann	ann	PROPN
fnp-4366	544	105	&	&	CCONJ
fnp-4366	544	106	robert	robert	PROPN
fnp-4366	544	107	h.	h.	PROPN
fnp-4366	544	108	lurie	lurie	PROPN
fnp-4366	544	109	children	children	PROPN
fnp-4366	544	110	’s	’s	PART
fnp-4366	544	111	hospital	hospital	NOUN
fnp-4366	544	112	of	of	ADP
fnp-4366	544	113	chicago	chicago	PROPN
fnp-4366	544	114	,	,	PUNCT
fnp-4366	544	115	chicago	chicago	PROPN
fnp-4366	544	116	,	,	PUNCT
fnp-4366	544	117	united	united	PROPN
fnp-4366	544	118	states	states	PROPN
fnp-4366	544	119	4	4	NUM
fnp-4366	544	120	the	the	DET
fnp-4366	544	121	hospital	hospital	NOUN
fnp-4366	544	122	for	for	ADP
fnp-4366	544	123	sick	sick	ADJ
fnp-4366	544	124	children	child	NOUN
fnp-4366	544	125	,	,	PUNCT
fnp-4366	544	126	toronto	toronto	PROPN
fnp-4366	544	127	,	,	PUNCT
fnp-4366	544	128	canada	canada	PROPN
fnp-4366	544	129	5	5	NUM
fnp-4366	544	130	national	national	PROPN
fnp-4366	544	131	institutes	institutes	PROPN
fnp-4366	544	132	of	of	ADP
fnp-4366	544	133	health	health	NOUN
fnp-4366	544	134	,	,	PUNCT
fnp-4366	544	135	bethesda	bethesda	NOUN
fnp-4366	544	136	,	,	PUNCT
fnp-4366	544	137	united	united	PROPN
fnp-4366	544	138	states	states	PROPN
fnp-4366	544	139	6	6	NUM
fnp-4366	544	140	university	university	NOUN
fnp-4366	544	141	of	of	ADP
fnp-4366	544	142	iowa	iowa	PROPN
fnp-4366	544	143	hospitals	hospital	NOUN
fnp-4366	544	144	and	and	CCONJ
fnp-4366	544	145	clinics	clinic	NOUN
fnp-4366	544	146	medicine	medicine	NOUN
fnp-4366	544	147	specialty	specialty	NOUN
fnp-4366	544	148	clinics	clinic	NOUN
fnp-4366	544	149	,	,	PUNCT
fnp-4366	544	150	iowa	iowa	PROPN
fnp-4366	544	151	city	city	PROPN
fnp-4366	544	152	,	,	PUNCT
fnp-4366	544	153	united	united	PROPN
fnp-4366	544	154	states	states	PROPN
fnp-4366	544	155	7	7	NUM
fnp-4366	544	156	institut	institut	PROPN
fnp-4366	544	157	de	de	PROPN
fnp-4366	544	158	myologie	myologie	PROPN
fnp-4366	544	159	,	,	PUNCT
fnp-4366	544	160	paris	paris	PROPN
fnp-4366	544	161	,	,	PUNCT
fnp-4366	544	162	france	france	PROPN
fnp-4366	544	163	8	8	NUM
fnp-4366	544	164	mduk	mduk	NOUN
fnp-4366	544	165	oxford	oxford	ADJ
fnp-4366	544	166	neuromuscular	neuromuscular	ADJ
fnp-4366	544	167	centre	centre	NOUN
fnp-4366	544	168	,	,	PUNCT
fnp-4366	544	169	oxford	oxford	PROPN
fnp-4366	544	170	,	,	PUNCT
fnp-4366	544	171	united	united	ADJ
fnp-4366	544	172	kingdom	kingdom	PROPN
fnp-4366	544	173	9	9	NUM
fnp-4366	544	174	astellas	astellas	NOUN
fnp-4366	544	175	gene	gene	NOUN
fnp-4366	544	176	therapies	therapy	NOUN
fnp-4366	544	177	,	,	PUNCT
fnp-4366	544	178	california	california	PROPN
fnp-4366	544	179	,	,	PUNCT
fnp-4366	544	180	united	united	PROPN
fnp-4366	544	181	states	states	PROPN
fnp-4366	544	182	10	10	NUM
fnp-4366	544	183	astellas	astella	NOUN
fnp-4366	544	184	pharma	pharma	PROPN
fnp-4366	544	185	global	global	ADJ
fnp-4366	544	186	development	development	PROPN
fnp-4366	544	187	,	,	PUNCT
fnp-4366	544	188	northbrook	northbrook	PROPN
fnp-4366	544	189	,	,	PUNCT
fnp-4366	544	190	united	united	PROPN
fnp-4366	544	191	states	states	PROPN
fnp-4366	544	192	11	11	NUM
fnp-4366	544	193	formerly	formerly	ADV
fnp-4366	544	194	astellas	astellas	ADJ
fnp-4366	544	195	gene	gene	NOUN
fnp-4366	544	196	therapies	therapy	NOUN
fnp-4366	544	197	,	,	PUNCT
fnp-4366	544	198	california	california	PROPN
fnp-4366	544	199	,	,	PUNCT
fnp-4366	544	200	united	united	PROPN
fnp-4366	544	201	states	states	PROPN
fnp-4366	544	202	background	background	NOUN
fnp-4366	544	203	:	:	PUNCT
fnp-4366	544	204	xlmtm	xlmtm	PROPN
fnp-4366	544	205	is	be	AUX
fnp-4366	544	206	a	a	DET
fnp-4366	544	207	rare	rare	ADJ
fnp-4366	544	208	,	,	PUNCT
fnp-4366	544	209	life	life	NOUN
fnp-4366	544	210	-	-	PUNCT
fnp-4366	544	211	threatening	threaten	VERB
fnp-4366	544	212	congenital	congenital	ADJ
fnp-4366	544	213	myopathy	myopathy	NOUN
fnp-4366	544	214	caused	cause	VERB
fnp-4366	544	215	by	by	ADP
fnp-4366	544	216	mutations	mutation	NOUN
fnp-4366	544	217	in	in	ADP
fnp-4366	544	218	the	the	DET
fnp-4366	544	219	mtm1	mtm1	NOUN
fnp-4366	544	220	gene	gene	NOUN
fnp-4366	544	221	.	.	PUNCT
fnp-4366	545	1	there	there	PRON
fnp-4366	545	2	is	be	VERB
fnp-4366	545	3	no	no	DET
fnp-4366	545	4	approved	approved	ADJ
fnp-4366	545	5	treatment	treatment	NOUN
fnp-4366	545	6	for	for	ADP
fnp-4366	545	7	xlmtm	xlmtm	PROPN
fnp-4366	545	8	.	.	PUNCT
fnp-4366	546	1	objectives	objective	NOUN
fnp-4366	546	2	:	:	PUNCT
fnp-4366	546	3	aspiro	aspiro	PROPN
fnp-4366	546	4	(	(	PUNCT
fnp-4366	546	5	nct03199469	nct03199469	ADJ
fnp-4366	546	6	)	)	PUNCT
fnp-4366	546	7	,	,	PUNCT
fnp-4366	546	8	a	a	DET
fnp-4366	546	9	phase	phase	NOUN
fnp-4366	546	10	1/2/3	1/2/3	NUM
fnp-4366	546	11	randomized	randomize	VERB
fnp-4366	546	12	,	,	PUNCT
fnp-4366	546	13	open	open	ADJ
fnp-4366	546	14	-	-	PUNCT
fnp-4366	546	15	label	label	NOUN
fnp-4366	546	16	study	study	NOUN
fnp-4366	546	17	is	be	AUX
fnp-4366	546	18	investigating	investigate	VERB
fnp-4366	546	19	the	the	DET
fnp-4366	546	20	safety	safety	NOUN
fnp-4366	546	21	and	and	CCONJ
fnp-4366	546	22	efficacy	efficacy	NOUN
fnp-4366	546	23	of	of	ADP
fnp-4366	546	24	at132	at132	PROPN
fnp-4366	546	25	(	(	PUNCT
fnp-4366	546	26	resamirigene	resamirigene	NOUN
fnp-4366	546	27	bilparvovec	bilparvovec	PROPN
fnp-4366	546	28	)	)	PUNCT
fnp-4366	546	29	,	,	PUNCT
fnp-4366	546	30	a	a	DET
fnp-4366	546	31	single	single	ADJ
fnp-4366	546	32	-	-	PUNCT
fnp-4366	546	33	dose	dose	VERB
fnp-4366	546	34	gene	gene	NOUN
fnp-4366	546	35	replacement	replacement	NOUN
fnp-4366	546	36	therapy	therapy	NOUN
fnp-4366	546	37	for	for	ADP
fnp-4366	546	38	ventilatory	ventilatory	ADJ
fnp-4366	546	39	-	-	PUNCT
fnp-4366	546	40	dependent	dependent	ADJ
fnp-4366	546	41	xlmtm	xlmtm	PROPN
fnp-4366	546	42	.	.	PUNCT
fnp-4366	547	1	question	question	NOUN
fnp-4366	547	2	:	:	PUNCT
fnp-4366	547	3	what	what	PRON
fnp-4366	547	4	is	be	AUX
fnp-4366	547	5	the	the	DET
fnp-4366	547	6	primary	primary	ADJ
fnp-4366	547	7	safety	safety	NOUN
fnp-4366	547	8	and	and	CCONJ
fnp-4366	547	9	efficacy	efficacy	NOUN
fnp-4366	547	10	data	datum	NOUN
fnp-4366	547	11	from	from	ADP
fnp-4366	547	12	asprio	asprio	PROPN
fnp-4366	547	13	?	?	PUNCT
fnp-4366	548	1	methods	method	NOUN
fnp-4366	548	2	:	:	PUNCT
fnp-4366	548	3	participants	participant	NOUN
fnp-4366	548	4	were	be	AUX
fnp-4366	548	5	young	young	ADJ
fnp-4366	548	6	boys	boy	NOUN
fnp-4366	548	7	with	with	ADP
fnp-4366	548	8	genetically	genetically	ADV
fnp-4366	548	9	confirmed	confirm	VERB
fnp-4366	548	10	xlmtm	xlmtm	PROPN
fnp-4366	548	11	.	.	PUNCT
fnp-4366	549	1	the	the	DET
fnp-4366	549	2	primary	primary	ADJ
fnp-4366	549	3	efficacy	efficacy	NOUN
fnp-4366	549	4	outcome	outcome	NOUN
fnp-4366	549	5	was	be	AUX
fnp-4366	549	6	the	the	DET
fnp-4366	549	7	change	change	NOUN
fnp-4366	549	8	in	in	ADP
fnp-4366	549	9	hours	hour	NOUN
fnp-4366	549	10	of	of	ADP
fnp-4366	549	11	daily	daily	ADJ
fnp-4366	549	12	ventilator	ventilator	NOUN
fnp-4366	549	13	support	support	NOUN
fnp-4366	549	14	from	from	ADP
fnp-4366	549	15	baseline	baseline	NOUN
fnp-4366	549	16	through	through	ADP
fnp-4366	549	17	week	week	NOUN
fnp-4366	549	18	48	48	NUM
fnp-4366	549	19	.	.	PUNCT
fnp-4366	550	1	the	the	DET
fnp-4366	550	2	key	key	ADJ
fnp-4366	550	3	secondary	secondary	ADJ
fnp-4366	550	4	efficacy	efficacy	NOUN
fnp-4366	550	5	outcome	outcome	NOUN
fnp-4366	550	6	was	be	AUX
fnp-4366	550	7	percentage	percentage	NOUN
fnp-4366	550	8	of	of	ADP
fnp-4366	550	9	participants	participant	NOUN
fnp-4366	550	10	who	who	PRON
fnp-4366	550	11	achieve	achieve	VERB
fnp-4366	550	12	functionally	functionally	ADV
fnp-4366	550	13	independent	independent	ADJ
fnp-4366	550	14	sitting	sitting	NOUN
fnp-4366	550	15	by	by	ADP
fnp-4366	550	16	week	week	NOUN
fnp-4366	550	17	48	48	NUM
fnp-4366	550	18	.	.	PUNCT
fnp-4366	551	1	we	we	PRON
fnp-4366	551	2	report	report	VERB
fnp-4366	551	3	long	long	ADJ
fnp-4366	551	4	-	-	PUNCT
fnp-4366	551	5	term	term	NOUN
fnp-4366	551	6	safety	safety	NOUN
fnp-4366	551	7	and	and	CCONJ
fnp-4366	551	8	key	key	ADJ
fnp-4366	551	9	efficacy	efficacy	NOUN
fnp-4366	551	10	outcomes	outcome	NOUN
fnp-4366	551	11	(	(	PUNCT
fnp-4366	551	12	up	up	ADP
fnp-4366	551	13	to	to	PART
fnp-4366	551	14	42	42	NUM
fnp-4366	551	15	months	month	NOUN
fnp-4366	552	1	[	[	X
fnp-4366	552	2	m	m	X
fnp-4366	552	3	]	]	X
fnp-4366	552	4	)	)	PUNCT
fnp-4366	552	5	for	for	ADP
fnp-4366	552	6	the	the	DET
fnp-4366	552	7	first	first	ADJ
fnp-4366	552	8	6	6	NUM
fnp-4366	552	9	participants	participant	NOUN
fnp-4366	552	10	dosed	dose	VERB
fnp-4366	552	11	in	in	ADP
fnp-4366	552	12	aspiro	aspiro	ADJ
fnp-4366	552	13	,	,	PUNCT
fnp-4366	552	14	all	all	PRON
fnp-4366	552	15	receiving	receive	VERB
fnp-4366	552	16	the	the	DET
fnp-4366	552	17	lower	lower	ADV
fnp-4366	552	18	-	-	PUNCT
fnp-4366	552	19	dose	dose	NOUN
fnp-4366	552	20	of	of	ADP
fnp-4366	552	21	1.3	1.3	NUM
fnp-4366	552	22	x	x	SYM
fnp-4366	552	23	1014	1014	NUM
fnp-4366	552	24	vg	vg	NOUN
fnp-4366	552	25	/	/	SYM
fnp-4366	552	26	kg	kg	NOUN
fnp-4366	552	27	and	and	CCONJ
fnp-4366	552	28	compared	compare	VERB
fnp-4366	552	29	with	with	ADP
fnp-4366	552	30	15	15	NUM
fnp-4366	552	31	untreated	untreated	ADJ
fnp-4366	552	32	controls	control	NOUN
fnp-4366	552	33	(	(	PUNCT
fnp-4366	552	34	including	include	VERB
fnp-4366	552	35	12	12	NUM
fnp-4366	552	36	participants	participant	NOUN
fnp-4366	552	37	from	from	ADP
fnp-4366	552	38	inceptus	inceptus	PROPN
fnp-4366	552	39	)	)	PUNCT
fnp-4366	552	40	,	,	PUNCT
fnp-4366	552	41	as	as	ADP
fnp-4366	552	42	of	of	ADP
fnp-4366	552	43	29jan2021	29jan2021	NUM
fnp-4366	552	44	.	.	PUNCT
fnp-4366	553	1	results	result	NOUN
fnp-4366	553	2	:	:	PUNCT
fnp-4366	553	3	the	the	DET
fnp-4366	553	4	mean	mean	ADJ
fnp-4366	553	5	age	age	NOUN
fnp-4366	553	6	at	at	ADP
fnp-4366	553	7	dosing	dose	VERB
fnp-4366	553	8	was	be	AUX
fnp-4366	553	9	20·4	20·4	NUM
fnp-4366	553	10	m	m	NOUN
fnp-4366	553	11	(	(	PUNCT
fnp-4366	553	12	range	range	NOUN
fnp-4366	553	13	:	:	PUNCT
fnp-4366	553	14	9·5	9·5	NUM
fnp-4366	553	15	-	-	PUNCT
fnp-4366	553	16	49·7	49·7	NOUN
fnp-4366	553	17	m	m	PROPN
fnp-4366	553	18	)	)	PUNCT
fnp-4366	553	19	and	and	CCONJ
fnp-4366	553	20	19·6	19·6	NUM
fnp-4366	553	21	m	m	PROPN
fnp-4366	553	22	(	(	PUNCT
fnp-4366	553	23	5·9	5·9	NUM
fnp-4366	553	24	-	-	SYM
fnp-4366	553	25	39·3	39·3	NUM
fnp-4366	553	26	m	m	NOUN
fnp-4366	553	27	)	)	PUNCT
fnp-4366	553	28	at	at	ADP
fnp-4366	553	29	enrollment	enrollment	NOUN
fnp-4366	553	30	among	among	ADP
fnp-4366	553	31	dosed	dose	VERB
fnp-4366	553	32	participants	participant	NOUN
fnp-4366	553	33	and	and	CCONJ
fnp-4366	553	34	controls	control	NOUN
fnp-4366	553	35	,	,	PUNCT
fnp-4366	553	36	respectively	respectively	ADV
fnp-4366	553	37	.	.	PUNCT
fnp-4366	554	1	major	major	ADJ
fnp-4366	554	2	developmental	developmental	ADJ
fnp-4366	554	3	milestones	milestone	NOUN
fnp-4366	554	4	achieved	achieve	VERB
fnp-4366	554	5	by	by	ADP
fnp-4366	554	6	all	all	DET
fnp-4366	554	7	dosed	dose	VERB
fnp-4366	554	8	participants	participant	NOUN
fnp-4366	554	9	over	over	ADP
fnp-4366	554	10	time	time	NOUN
fnp-4366	554	11	is	be	AUX
fnp-4366	554	12	shown	show	VERB
fnp-4366	554	13	in	in	ADP
fnp-4366	554	14	figure	figure	NOUN
fnp-4366	554	15	1	1	NUM
fnp-4366	554	16	.	.	PUNCT
fnp-4366	555	1	all	all	DET
fnp-4366	555	2	dosed	dose	VERB
fnp-4366	555	3	participants	participant	NOUN
fnp-4366	555	4	were	be	AUX
fnp-4366	555	5	ventilator	ventilator	NOUN
fnp-4366	555	6	dependent	dependent	ADJ
fnp-4366	555	7	at	at	ADP
fnp-4366	555	8	first	first	ADJ
fnp-4366	555	9	assessment	assessment	NOUN
fnp-4366	555	10	;	;	PUNCT
fnp-4366	555	11	5	5	NUM
fnp-4366	555	12	(	(	PUNCT
fnp-4366	555	13	83.33	83.33	NUM
fnp-4366	555	14	%	%	NOUN
fnp-4366	555	15	)	)	PUNCT
fnp-4366	555	16	requiring	require	VERB
fnp-4366	555	17	transtracheal	transtracheal	NOUN
fnp-4366	555	18	invasive	invasive	ADJ
fnp-4366	555	19	ventilation	ventilation	NOUN
fnp-4366	555	20	>	>	ADP
fnp-4366	555	21	22	22	NUM
fnp-4366	555	22	hours	hour	NOUN
fnp-4366	555	23	/	/	SYM
fnp-4366	555	24	day	day	NOUN
fnp-4366	555	25	and	and	CCONJ
fnp-4366	555	26	1	1	NUM
fnp-4366	555	27	(	(	PUNCT
fnp-4366	555	28	16.67	16.67	NUM
fnp-4366	555	29	%	%	NOUN
fnp-4366	555	30	)	)	PUNCT
fnp-4366	555	31	used	use	VERB
fnp-4366	555	32	non	non	ADJ
fnp-4366	555	33	-	-	ADJ
fnp-4366	555	34	invasive	invasive	ADJ
fnp-4366	555	35	ventilation	ventilation	NOUN
fnp-4366	555	36	of	of	ADP
fnp-4366	555	37	12	12	NUM
fnp-4366	555	38	hours	hour	NOUN
fnp-4366	555	39	/	/	SYM
fnp-4366	555	40	day	day	NOUN
fnp-4366	555	41	.	.	PUNCT
fnp-4366	556	1	all	all	DET
fnp-4366	556	2	dosed	dose	VERB
fnp-4366	556	3	participants	participant	NOUN
fnp-4366	556	4	achieved	achieve	VERB
fnp-4366	556	5	ventilator	ventilator	NOUN
fnp-4366	556	6	independence	independence	NOUN
fnp-4366	556	7	,	,	PUNCT
fnp-4366	556	8	5	5	NUM
fnp-4366	556	9	remain	remain	VERB
fnp-4366	556	10	so	so	ADV
fnp-4366	556	11	(	(	PUNCT
fnp-4366	556	12	mean	mean	VERB
fnp-4366	556	13	durability	durability	NOUN
fnp-4366	556	14	25.6	25.6	NUM
fnp-4366	556	15	m	m	NOUN
fnp-4366	556	16	;	;	PUNCT
fnp-4366	556	17	range	range	VERB
fnp-4366	556	18	18.3	18.3	NUM
fnp-4366	556	19	-	-	SYM
fnp-4366	556	20	36.6	36.6	NUM
fnp-4366	556	21	m	m	NOUN
fnp-4366	556	22	)	)	PUNCT
fnp-4366	556	23	of	of	ADP
fnp-4366	556	24	which	which	PRON
fnp-4366	556	25	4	4	NUM
fnp-4366	556	26	have	have	AUX
fnp-4366	556	27	been	be	AUX
fnp-4366	556	28	decannulated	decannulate	VERB
fnp-4366	556	29	.	.	PUNCT
fnp-4366	557	1	no	no	DET
fnp-4366	557	2	control	control	NOUN
fnp-4366	557	3	participants	participant	NOUN
fnp-4366	557	4	became	become	VERB
fnp-4366	557	5	ventilator	ventilator	NOUN
fnp-4366	557	6	independent	independent	ADJ
fnp-4366	557	7	or	or	CCONJ
fnp-4366	557	8	were	be	AUX
fnp-4366	557	9	decannulated	decannulate	VERB
fnp-4366	557	10	.	.	PUNCT
fnp-4366	558	1	at	at	ADP
fnp-4366	558	2	baseline	baseline	NOUN
fnp-4366	558	3	,	,	PUNCT
fnp-4366	558	4	1/6	1/6	DET
fnp-4366	558	5	dosed	dose	VERB
fnp-4366	558	6	participant	participant	NOUN
fnp-4366	558	7	was	be	AUX
fnp-4366	558	8	able	able	ADJ
fnp-4366	558	9	to	to	PART
fnp-4366	558	10	sit	sit	VERB
fnp-4366	558	11	independently	independently	ADV
fnp-4366	558	12	without	without	ADP
fnp-4366	558	13	support	support	NOUN
fnp-4366	558	14	for	for	ADP
fnp-4366	558	15	30	30	NUM
fnp-4366	558	16	seconds	second	NOUN
fnp-4366	558	17	;	;	PUNCT
fnp-4366	558	18	5/6	5/6	NUM
fnp-4366	558	19	participants	participant	NOUN
fnp-4366	558	20	did	do	AUX
fnp-4366	558	21	not	not	PART
fnp-4366	558	22	have	have	VERB
fnp-4366	558	23	full	full	ADJ
fnp-4366	558	24	head	head	NOUN
fnp-4366	558	25	control	control	NOUN
fnp-4366	558	26	and	and	CCONJ
fnp-4366	558	27	were	be	AUX
fnp-4366	558	28	unable	unable	ADJ
fnp-4366	558	29	to	to	PART
fnp-4366	558	30	sit	sit	VERB
fnp-4366	558	31	independently	independently	ADV
fnp-4366	558	32	.	.	PUNCT
fnp-4366	559	1	major	major	ADJ
fnp-4366	559	2	motor	motor	NOUN
fnp-4366	559	3	milestones	milestone	NOUN
fnp-4366	559	4	were	be	AUX
fnp-4366	559	5	achieved	achieve	VERB
fnp-4366	559	6	in	in	ADP
fnp-4366	559	7	all	all	DET
fnp-4366	559	8	dosed	dose	VERB
fnp-4366	559	9	participants	participant	NOUN
fnp-4366	559	10	(	(	PUNCT
fnp-4366	559	11	figure	figure	NOUN
fnp-4366	559	12	1	1	NUM
fnp-4366	559	13	)	)	PUNCT
fnp-4366	559	14	;	;	PUNCT
fnp-4366	559	15	5/6	5/6	NUM
fnp-4366	559	16	remain	remain	VERB
fnp-4366	559	17	independently	independently	ADV
fnp-4366	559	18	ambulatory	ambulatory	ADJ
fnp-4366	559	19	without	without	ADP
fnp-4366	559	20	assistive	assistive	ADJ
fnp-4366	559	21	device	device	NOUN
fnp-4366	559	22	(	(	PUNCT
fnp-4366	559	23	achieved	achieve	VERB
fnp-4366	559	24	mean	mean	NOUN
fnp-4366	559	25	[	[	X
fnp-4366	559	26	sd	sd	X
fnp-4366	559	27	]	]	PUNCT
fnp-4366	559	28	time	time	NOUN
fnp-4366	559	29	21.92	21.92	NUM
fnp-4366	559	30	[	[	X
fnp-4366	559	31	5.57]m	5.57]m	NUM
fnp-4366	559	32	)	)	PUNCT
fnp-4366	559	33	;	;	PUNCT
fnp-4366	559	34	4	4	NUM
fnp-4366	559	35	of	of	ADP
fnp-4366	559	36	whom	whom	PRON
fnp-4366	559	37	have	have	AUX
fnp-4366	559	38	achieved	achieve	VERB
fnp-4366	559	39	the	the	DET
fnp-4366	559	40	ability	ability	NOUN
fnp-4366	559	41	to	to	PART
fnp-4366	559	42	ascend	ascend	VERB
fnp-4366	559	43	stairs	stair	NOUN
fnp-4366	559	44	.	.	PUNCT
fnp-4366	560	1	5/15	5/15	NUM
fnp-4366	560	2	(	(	PUNCT
fnp-4366	560	3	33.3	33.3	NUM
fnp-4366	560	4	%	%	NOUN
fnp-4366	560	5	)	)	PUNCT
fnp-4366	560	6	control	control	NOUN
fnp-4366	560	7	participants	participant	NOUN
fnp-4366	560	8	achieved	achieve	VERB
fnp-4366	560	9	independent	independent	ADJ
fnp-4366	560	10	sitting	sitting	NOUN
fnp-4366	560	11	;	;	PUNCT
fnp-4366	560	12	none	none	NOUN
fnp-4366	560	13	achieved	achieve	VERB
fnp-4366	560	14	higher	high	ADJ
fnp-4366	560	15	milestones	milestone	NOUN
fnp-4366	560	16	.	.	PUNCT
fnp-4366	561	1	among	among	ADP
fnp-4366	561	2	6	6	NUM
fnp-4366	561	3	dosed	dose	VERB
fnp-4366	561	4	in	in	ADP
fnp-4366	561	5	cohort	cohort	NOUN
fnp-4366	561	6	1	1	NUM
fnp-4366	561	7	,	,	PUNCT
fnp-4366	561	8	4	4	NUM
fnp-4366	561	9	(	(	PUNCT
fnp-4366	561	10	67	67	NUM
fnp-4366	561	11	%	%	NOUN
fnp-4366	561	12	)	)	PUNCT
fnp-4366	561	13	participants	participant	NOUN
fnp-4366	561	14	experienced	experience	VERB
fnp-4366	561	15	treatment	treatment	NOUN
fnp-4366	561	16	-	-	PUNCT
fnp-4366	561	17	emergent	emergent	NOUN
fnp-4366	561	18	severe	severe	ADJ
fnp-4366	561	19	adverse	adverse	ADJ
fnp-4366	561	20	events	event	NOUN
fnp-4366	561	21	;	;	PUNCT
fnp-4366	561	22	infections	infection	NOUN
fnp-4366	561	23	in	in	ADP
fnp-4366	561	24	4	4	NUM
fnp-4366	561	25	(	(	PUNCT
fnp-4366	561	26	67	67	NUM
fnp-4366	561	27	%	%	NOUN
fnp-4366	561	28	)	)	PUNCT
fnp-4366	561	29	and	and	CCONJ
fnp-4366	561	30	respiratory	respiratory	ADJ
fnp-4366	561	31	/	/	SYM
fnp-4366	561	32	thoracic	thoracic	NOUN
fnp-4366	561	33	/	/	SYM
fnp-4366	561	34	mediastinal	mediastinal	ADJ
fnp-4366	561	35	disorders	disorder	NOUN
fnp-4366	561	36	in	in	ADP
fnp-4366	561	37	1(17	1(17	NUM
fnp-4366	561	38	%	%	NOUN
fnp-4366	561	39	)	)	PUNCT
fnp-4366	561	40	.	.	PUNCT
fnp-4366	562	1	all	all	DET
fnp-4366	562	2	dosed	dose	VERB
fnp-4366	562	3	participants	participant	NOUN
fnp-4366	562	4	currently	currently	ADV
fnp-4366	562	5	have	have	VERB
fnp-4366	562	6	stable	stable	ADJ
fnp-4366	562	7	liver	liver	NOUN
fnp-4366	562	8	function	function	NOUN
fnp-4366	562	9	test	test	NOUN
fnp-4366	562	10	values	value	NOUN
fnp-4366	562	11	.	.	PUNCT
fnp-4366	563	1	as	as	ADP
fnp-4366	563	2	of	of	ADP
fnp-4366	563	3	january	january	PROPN
fnp-4366	563	4	2021	2021	NUM
fnp-4366	563	5	,	,	PUNCT
fnp-4366	563	6	three	three	NUM
fnp-4366	563	7	deaths	death	NOUN
fnp-4366	563	8	in	in	ADP
fnp-4366	563	9	the	the	DET
fnp-4366	563	10	higher	higher	ADV
fnp-4366	563	11	-	-	PUNCT
fnp-4366	563	12	dose	dose	NOUN
fnp-4366	563	13	cohort	cohort	NOUN
fnp-4366	563	14	occurred	occur	VERB
fnp-4366	563	15	following	follow	VERB
fnp-4366	563	16	severe	severe	ADJ
fnp-4366	563	17	decompensated	decompensate	VERB
fnp-4366	563	18	liver	liver	NOUN
fnp-4366	563	19	disease	disease	NOUN
fnp-4366	563	20	,	,	PUNCT
fnp-4366	563	21	and	and	CCONJ
fnp-4366	563	22	three	three	NUM
fnp-4366	563	23	deaths	death	NOUN
fnp-4366	563	24	in	in	ADP
fnp-4366	563	25	the	the	DET
fnp-4366	563	26	control	control	NOUN
fnp-4366	563	27	cohort	cohort	NOUN
fnp-4366	563	28	(	(	PUNCT
fnp-4366	563	29	aspiration	aspiration	NOUN
fnp-4366	563	30	pneumonia	pneumonia	NOUN
fnp-4366	563	31	;	;	PUNCT
fnp-4366	563	32	cardiopulmonary	cardiopulmonary	ADJ
fnp-4366	563	33	failure	failure	NOUN
fnp-4366	563	34	;	;	PUNCT
fnp-4366	563	35	hepatic	hepatic	ADJ
fnp-4366	563	36	hemorrhage	hemorrhage	NOUN
fnp-4366	563	37	with	with	ADP
fnp-4366	563	38	peliosis	peliosis	NOUN
fnp-4366	563	39	)	)	PUNCT
fnp-4366	563	40	were	be	AUX
fnp-4366	563	41	observed	observe	VERB
fnp-4366	563	42	.	.	PUNCT
fnp-4366	564	1	as	as	ADP
fnp-4366	564	2	of	of	ADP
fnp-4366	564	3	september	september	PROPN
fnp-4366	564	4	2021	2021	NUM
fnp-4366	564	5	,	,	PUNCT
fnp-4366	564	6	a	a	DET
fnp-4366	564	7	newly	newly	ADV
fnp-4366	564	8	dosed	dose	VERB
fnp-4366	564	9	participant	participant	NOUN
fnp-4366	564	10	in	in	ADP
fnp-4366	564	11	the	the	DET
fnp-4366	564	12	lower	lower	ADV
fnp-4366	564	13	-	-	PUNCT
fnp-4366	564	14	dose	dose	VERB
fnp-4366	564	15	cohort	cohort	NOUN
fnp-4366	564	16	experienced	experience	VERB
fnp-4366	564	17	severe	severe	ADJ
fnp-4366	564	18	liver	liver	NOUN
fnp-4366	564	19	function	function	NOUN
fnp-4366	564	20	test	test	NOUN
fnp-4366	564	21	abnormalities	abnormality	NOUN
fnp-4366	564	22	and	and	CCONJ
fnp-4366	564	23	has	have	AUX
fnp-4366	564	24	died	die	VERB
fnp-4366	564	25	.	.	PUNCT
fnp-4366	565	1	conclusions	conclusion	NOUN
fnp-4366	565	2	:	:	PUNCT
fnp-4366	565	3	a	a	DET
fnp-4366	565	4	rapid	rapid	ADJ
fnp-4366	565	5	improvement	improvement	NOUN
fnp-4366	565	6	in	in	ADP
fnp-4366	565	7	respiratory	respiratory	ADJ
fnp-4366	565	8	and	and	CCONJ
fnp-4366	565	9	motor	motor	NOUN
fnp-4366	565	10	outcomes	outcome	NOUN
fnp-4366	565	11	was	be	AUX
fnp-4366	565	12	observed	observe	VERB
fnp-4366	565	13	among	among	ADP
fnp-4366	565	14	6	6	NUM
fnp-4366	565	15	xlmtm	xlmtm	ADJ
fnp-4366	565	16	participants	participant	NOUN
fnp-4366	565	17	dosed	dose	VERB
fnp-4366	565	18	with	with	ADP
fnp-4366	565	19	at132	at132	PROPN
fnp-4366	565	20	at	at	ADP
fnp-4366	565	21	1.3	1.3	NUM
fnp-4366	565	22	x	x	SYM
fnp-4366	565	23	1014	1014	NUM
fnp-4366	565	24	vg	vg	NOUN
fnp-4366	565	25	/	/	SYM
fnp-4366	565	26	kg	kg	PROPN
fnp-4366	565	27	vs	vs	ADP
fnp-4366	565	28	control	control	NOUN
fnp-4366	565	29	participants	participant	NOUN
fnp-4366	565	30	;	;	PUNCT
fnp-4366	565	31	these	these	DET
fnp-4366	565	32	improvements	improvement	NOUN
fnp-4366	565	33	have	have	AUX
fnp-4366	565	34	been	be	AUX
fnp-4366	565	35	maintained	maintain	VERB
fnp-4366	565	36	and	and	CCONJ
fnp-4366	565	37	expanded	expand	VERB
fnp-4366	565	38	upon	upon	SCONJ
fnp-4366	565	39	over	over	ADP
fnp-4366	565	40	time	time	NOUN
fnp-4366	565	41	,	,	PUNCT
fnp-4366	565	42	indicating	indicate	VERB
fnp-4366	565	43	improved	improved	ADJ
fnp-4366	565	44	strength	strength	NOUN
fnp-4366	565	45	,	,	PUNCT
fnp-4366	565	46	function	function	NOUN
fnp-4366	565	47	,	,	PUNCT
fnp-4366	565	48	and	and	CCONJ
fnp-4366	565	49	quality	quality	NOUN
fnp-4366	565	50	of	of	ADP
fnp-4366	565	51	life	life	NOUN
fnp-4366	565	52	for	for	ADP
fnp-4366	565	53	these	these	DET
fnp-4366	565	54	dosed	dose	VERB
fnp-4366	565	55	participants	participant	NOUN
fnp-4366	565	56	.	.	PUNCT
fnp-4366	566	1	these	these	DET
fnp-4366	566	2	substantial	substantial	ADJ
fnp-4366	566	3	improvements	improvement	NOUN
fnp-4366	566	4	must	must	AUX
fnp-4366	566	5	be	be	AUX
fnp-4366	566	6	weighed	weigh	VERB
fnp-4366	566	7	against	against	ADP
fnp-4366	566	8	the	the	DET
fnp-4366	566	9	occurrences	occurrence	NOUN
fnp-4366	566	10	of	of	ADP
fnp-4366	566	11	fatal	fatal	ADJ
fnp-4366	566	12	serious	serious	ADJ
fnp-4366	566	13	adverse	adverse	ADJ
fnp-4366	566	14	events	event	NOUN
fnp-4366	566	15	,	,	PUNCT
fnp-4366	566	16	for	for	ADP
fnp-4366	566	17	which	which	PRON
fnp-4366	566	18	the	the	DET
fnp-4366	566	19	aspiro	aspiro	ADJ
fnp-4366	566	20	program	program	NOUN
fnp-4366	566	21	is	be	AUX
fnp-4366	566	22	on	on	ADP
fnp-4366	566	23	clinical	clinical	ADJ
fnp-4366	566	24	hold	hold	NOUN
fnp-4366	566	25	while	while	SCONJ
fnp-4366	566	26	relevant	relevant	ADJ
fnp-4366	566	27	clinical	clinical	ADJ
fnp-4366	566	28	information	information	NOUN
fnp-4366	566	29	is	be	AUX
fnp-4366	566	30	being	be	AUX
fnp-4366	566	31	gathered	gather	VERB
fnp-4366	566	32	and	and	CCONJ
fnp-4366	566	33	reviewed	review	VERB
fnp-4366	566	34	.	.	PUNCT
fnp-4366	567	1	figure	figure	NOUN
fnp-4366	567	2	1	1	NUM
fnp-4366	567	3	:	:	PUNCT
fnp-4366	567	4	developmental	developmental	ADJ
fnp-4366	567	5	motor	motor	NOUN
fnp-4366	567	6	and	and	CCONJ
fnp-4366	567	7	respiratory	respiratory	ADJ
fnp-4366	567	8	milestones	milestone	NOUN
fnp-4366	567	9	achieved	achieve	VERB
fnp-4366	567	10	in	in	ADP
fnp-4366	567	11	xlmtm	xlmtm	PROPN
fnp-4366	567	12	patients	patient	NOUN
fnp-4366	567	13	dosed	dose	VERB
fnp-4366	567	14	at	at	ADP
fnp-4366	567	15	at132	at132	PROPN
fnp-4366	567	16	at	at	ADP
fnp-4366	567	17	1.3	1.3	NUM
fnp-4366	567	18	x	x	SYM
fnp-4366	567	19	1014	1014	NUM
fnp-4366	567	20	vg	vg	PROPN
fnp-4366	567	21	/	/	SYM
fnp-4366	567	22	kg	kg	NOUN
fnp-4366	567	23	.	.	PUNCT
fnp-4366	567	24	  	  	SPACE
fnp-4366	567	25	5.04	5.04	NUM
fnp-4366	567	26	free	free	ADJ
fnp-4366	567	27	neuropathol	neuropathol	NOUN
fnp-4366	567	28	3:20:54	3:20:54	NUM
fnp-4366	567	29	lymphotoxin	lymphotoxin	NOUN
fnp-4366	567	30	-	-	PUNCT
fnp-4366	567	31	driven	drive	VERB
fnp-4366	567	32	chronic	chronic	ADJ
fnp-4366	567	33	mucle	mucle	NOUN
fnp-4366	567	34	inflammation	inflammation	NOUN
fnp-4366	567	35	interdepends	interdepend	NOUN
fnp-4366	567	36	with	with	ADP
fnp-4366	567	37	impaired	impaired	ADJ
fnp-4366	567	38	autophagy	autophagy	NOUN
fnp-4366	567	39	,	,	PUNCT
fnp-4366	567	40	self	self	NOUN
fnp-4366	567	41	-	-	PUNCT
fnp-4366	567	42	perpetuates	perpetuate	NOUN
fnp-4366	567	43	and	and	CCONJ
fnp-4366	567	44	models	model	VERB
fnp-4366	567	45	inclusion	inclusion	NOUN
fnp-4366	567	46	body	body	NOUN
fnp-4366	567	47	myositis	myositis	NOUN
fnp-4366	567	48	in	in	ADP
fnp-4366	567	49	mice	mouse	NOUN
fnp-4366	567	50	juliane	juliane	PROPN
fnp-4366	567	51	bremer1	bremer1	PROPN
fnp-4366	567	52	,	,	PUNCT
fnp-4366	567	53	judith	judith	PROPN
fnp-4366	567	54	bauer2	bauer2	PROPN
fnp-4366	567	55	,	,	PUNCT
fnp-4366	567	56	jana	jana	PROPN
fnp-4366	567	57	zschüntzsch3	zschüntzsch3	PROPN
fnp-4366	567	58	,	,	PUNCT
fnp-4366	567	59	thomas	thomas	PROPN
fnp-4366	567	60	blank4	blank4	PROPN
fnp-4366	567	61	,	,	PUNCT
fnp-4366	567	62	kamil	kamil	PROPN
fnp-4366	567	63	zajt1	zajt1	PROPN
fnp-4366	567	64	,	,	PUNCT
fnp-4366	567	65	laura	laura	PROPN
fnp-4366	567	66	anna	anna	PROPN
fnp-4366	567	67	fischer3	fischer3	PROPN
fnp-4366	567	68	,	,	PUNCT
fnp-4366	567	69	anna	anna	PROPN
fnp-4366	567	70	sensmeyer3	sensmeyer3	PROPN
fnp-4366	567	71	,	,	PUNCT
fnp-4366	567	72	lara	lara	PROPN
fnp-4366	567	73	wiechers3	wiechers3	PROPN
fnp-4366	567	74	,	,	PUNCT
fnp-4366	567	75	josef	josef	PROPN
fnp-4366	567	76	reichelt3	reichelt3	PROPN
fnp-4366	567	77	,	,	PUNCT
fnp-4366	567	78	kai	kai	PROPN
fnp-4366	567	79	hofmann5	hofmann5	PROPN
fnp-4366	567	80	,	,	PUNCT
fnp-4366	567	81	monika	monika	PROPN
fnp-4366	567	82	wolf6	wolf6	PROPN
fnp-4366	567	83	,	,	PUNCT
fnp-4366	567	84	corinna	corinna	PROPN
fnp-4366	567	85	leuchtenberger5	leuchtenberger5	PROPN
fnp-4366	567	86	,	,	PUNCT
fnp-4366	567	87	priyanka	priyanka	PROPN
fnp-4366	567	88	tripathi1	tripathi1	PROPN
fnp-4366	567	89	,	,	PUNCT
fnp-4366	567	90	claudia	claudia	PROPN
fnp-4366	567	91	einer7	einer7	NOUN
fnp-4366	567	92	,	,	PUNCT
fnp-4366	567	93	hans	hans	PROPN
fnp-4366	567	94	zischka7	zischka7	PROPN
fnp-4366	567	95	,	,	PUNCT
fnp-4366	567	96	adriano	adriano	PROPN
fnp-4366	567	97	aguzzi6	aguzzi6	PROPN
fnp-4366	567	98	,	,	PUNCT
fnp-4366	567	99	regina	regina	PROPN
fnp-4366	567	100	reimann6	reimann6	PROPN
fnp-4366	567	101	,	,	PUNCT
fnp-4366	567	102	veronika	veronika	PROPN
fnp-4366	567	103	kana6,8	kana6,8	PROPN
fnp-4366	567	104	,	,	PUNCT
fnp-4366	567	105	elisabeth	elisabeth	PROPN
fnp-4366	567	106	rushing6	rushing6	PROPN
fnp-4366	567	107	,	,	PUNCT
fnp-4366	567	108	marco	marco	PROPN
fnp-4366	567	109	prinz4	prinz4	PROPN
fnp-4366	567	110	,	,	PUNCT
fnp-4366	567	111	david	david	PROPN
fnp-4366	567	112	liebetanz3	liebetanz3	PROPN
fnp-4366	567	113	,	,	PUNCT
fnp-4366	567	114	francesca	francesca	PROPN
fnp-4366	567	115	odoardi3	odoardi3	NOUN
fnp-4366	567	116	,	,	PUNCT
fnp-4366	567	117	joachim	joachim	PROPN
fnp-4366	567	118	weis1	weis1	PROPN
fnp-4366	567	119	,	,	PUNCT
fnp-4366	567	120	jens	jens	PROPN
fnp-4366	567	121	schmidt3,9	schmidt3,9	PROPN
fnp-4366	567	122	,	,	PUNCT
fnp-4366	567	123	mathias	mathia	NOUN
fnp-4366	567	124	heikenwälder5	heikenwälder5	VERB
fnp-4366	567	125	1	1	NUM
fnp-4366	567	126	uniklinik	uniklinik	NOUN
fnp-4366	567	127	rwth	rwth	NOUN
fnp-4366	567	128	aachen	aachen	PROPN
fnp-4366	567	129	,	,	PUNCT
fnp-4366	567	130	institut	institut	PROPN
fnp-4366	567	131	für	für	PROPN
fnp-4366	567	132	neuropathologie	neuropathologie	PROPN
fnp-4366	567	133	,	,	PUNCT
fnp-4366	567	134	aachen	aachen	PROPN
fnp-4366	567	135	,	,	PUNCT
fnp-4366	567	136	deutschland	deutschland	NOUN
fnp-4366	567	137	2	2	NUM
fnp-4366	567	138	technische	technische	PROPN
fnp-4366	567	139	universität	universität	PROPN
fnp-4366	567	140	münchen	münchen	PROPN
fnp-4366	567	141	,	,	PUNCT
fnp-4366	567	142	institut	institut	PROPN
fnp-4366	567	143	für	für	PROPN
fnp-4366	567	144	toxikologie	toxikologie	PROPN
fnp-4366	567	145	und	und	PROPN
fnp-4366	567	146	umwelthygiene	umwelthygiene	ADJ
fnp-4366	567	147	,	,	PUNCT
fnp-4366	567	148	münchen	münchen	NOUN
fnp-4366	567	149	,	,	PUNCT
fnp-4366	567	150	deutschland	deutschland	NOUN
fnp-4366	567	151	3	3	NUM
fnp-4366	567	152	universitätsmedizin	universitätsmedizin	NOUN
fnp-4366	567	153	göttingen	göttingen	NOUN
fnp-4366	567	154	,	,	PUNCT
fnp-4366	567	155	klinik	klinik	PROPN
fnp-4366	567	156	für	für	PROPN
fnp-4366	567	157	neurologie	neurologie	PROPN
fnp-4366	567	158	,	,	PUNCT
fnp-4366	567	159	göttingen	göttingen	NOUN
fnp-4366	567	160	,	,	PUNCT
fnp-4366	567	161	deutschland	deutschland	NOUN
fnp-4366	567	162	4	4	NUM
fnp-4366	567	163	universitätsklinikum	universitätsklinikum	NOUN
fnp-4366	567	164	freiburg	freiburg	PROPN
fnp-4366	567	165	,	,	PUNCT
fnp-4366	567	166	institut	institut	PROPN
fnp-4366	567	167	für	für	PROPN
fnp-4366	567	168	neuropathologie	neuropathologie	PROPN
fnp-4366	567	169	,	,	PUNCT
fnp-4366	567	170	freiburg	freiburg	PROPN
fnp-4366	567	171	,	,	PUNCT
fnp-4366	567	172	deutschland	deutschland	NOUN
fnp-4366	567	173	5	5	NUM
fnp-4366	567	174	dkfz	dkfz	PROPN
fnp-4366	567	175	heidelberg	heidelberg	PROPN
fnp-4366	567	176	,	,	PUNCT
fnp-4366	567	177	heidelberg	heidelberg	PROPN
fnp-4366	567	178	,	,	PUNCT
fnp-4366	567	179	deutschland	deutschland	NOUN
fnp-4366	567	180	6	6	NUM
fnp-4366	567	181	universitätsspital	universitätsspital	PROPN
fnp-4366	567	182	zürich	zürich	PROPN
fnp-4366	567	183	,	,	PUNCT
fnp-4366	567	184	institut	institut	PROPN
fnp-4366	567	185	für	für	PROPN
fnp-4366	567	186	neuropathologie	neuropathologie	PROPN
fnp-4366	567	187	,	,	PUNCT
fnp-4366	567	188	zürich	zürich	PROPN
fnp-4366	567	189	,	,	PUNCT
fnp-4366	567	190	switzerland	switzerland	PROPN
fnp-4366	567	191	7	7	NUM
fnp-4366	567	192	helmholtz	helmholtz	PROPN
fnp-4366	567	193	münchen	münchen	NOUN
fnp-4366	567	194	,	,	PUNCT
fnp-4366	567	195	institut	institut	PROPN
fnp-4366	567	196	für	für	PROPN
fnp-4366	567	197	molekulare	molekulare	PROPN
fnp-4366	567	198	toxikologie	toxikologie	PROPN
fnp-4366	567	199	und	und	NOUN
fnp-4366	567	200	pharmakologie	pharmakologie	NOUN
fnp-4366	567	201	,	,	PUNCT
fnp-4366	567	202	münchen	münchen	NOUN
fnp-4366	567	203	,	,	PUNCT
fnp-4366	567	204	deutschland	deutschland	NOUN
fnp-4366	567	205	8	8	NUM
fnp-4366	567	206	universitätsspital	universitätsspital	PROPN
fnp-4366	567	207	zürich	zürich	PROPN
fnp-4366	567	208	,	,	PUNCT
fnp-4366	567	209	klinik	klinik	PROPN
fnp-4366	567	210	für	für	PROPN
fnp-4366	567	211	neurologie	neurologie	PROPN
fnp-4366	567	212	,	,	PUNCT
fnp-4366	567	213	zürich	zürich	PROPN
fnp-4366	567	214	,	,	PUNCT
fnp-4366	567	215	switzerland	switzerland	PROPN
fnp-4366	567	216	9	9	NUM
fnp-4366	567	217	universitätsklinik	universitätsklinik	X
fnp-4366	567	218	der	der	NOUN
fnp-4366	567	219	medizinischen	medizinischen	PROPN
fnp-4366	567	220	hochschule	hochschule	PROPN
fnp-4366	567	221	brandenburg	brandenburg	PROPN
fnp-4366	567	222	,	,	PUNCT
fnp-4366	567	223	abteilung	abteilung	PROPN
fnp-4366	567	224	neurologie	neurologie	PROPN
fnp-4366	567	225	und	und	PROPN
fnp-4366	567	226	schmerztherapie	schmerztherapie	NOUN
fnp-4366	567	227	,	,	PUNCT
fnp-4366	567	228	rüdersdorf	rüdersdorf	PROPN
fnp-4366	567	229	,	,	PUNCT
fnp-4366	567	230	deutschland	deutschland	NOUN
fnp-4366	567	231	background	background	NOUN
fnp-4366	567	232	,	,	PUNCT
fnp-4366	567	233	goals	goal	NOUN
fnp-4366	567	234	and	and	CCONJ
fnp-4366	567	235	research	research	NOUN
fnp-4366	567	236	question	question	NOUN
fnp-4366	567	237	:	:	PUNCT
fnp-4366	567	238	inclusion	inclusion	NOUN
fnp-4366	567	239	body	body	NOUN
fnp-4366	567	240	myositis	myositis	PROPN
fnp-4366	567	241	(	(	PUNCT
fnp-4366	567	242	ibm	ibm	PROPN
fnp-4366	567	243	)	)	PUNCT
fnp-4366	567	244	is	be	AUX
fnp-4366	567	245	a	a	DET
fnp-4366	567	246	progressive	progressive	ADJ
fnp-4366	567	247	muscular	muscular	ADJ
fnp-4366	567	248	disorder	disorder	NOUN
fnp-4366	567	249	characterized	characterize	VERB
fnp-4366	567	250	by	by	ADP
fnp-4366	567	251	muscle	muscle	NOUN
fnp-4366	567	252	inflammation	inflammation	NOUN
fnp-4366	567	253	and	and	CCONJ
fnp-4366	567	254	degeneration	degeneration	NOUN
fnp-4366	567	255	including	include	VERB
fnp-4366	567	256	protein	protein	NOUN
fnp-4366	567	257	aggregates	aggregate	NOUN
fnp-4366	567	258	and	and	CCONJ
fnp-4366	567	259	altered	alter	VERB
fnp-4366	567	260	autophagic	autophagic	ADJ
fnp-4366	567	261	activity	activity	NOUN
fnp-4366	567	262	.	.	PUNCT
fnp-4366	568	1	the	the	DET
fnp-4366	568	2	combination	combination	NOUN
fnp-4366	568	3	of	of	ADP
fnp-4366	568	4	inflammatory	inflammatory	ADJ
fnp-4366	568	5	and	and	CCONJ
fnp-4366	568	6	degenerative	degenerative	ADJ
fnp-4366	568	7	features	feature	NOUN
fnp-4366	568	8	has	have	AUX
fnp-4366	568	9	led	lead	VERB
fnp-4366	568	10	to	to	ADP
fnp-4366	568	11	the	the	DET
fnp-4366	568	12	assumption	assumption	NOUN
fnp-4366	568	13	that	that	SCONJ
fnp-4366	568	14	this	this	DET
fnp-4366	568	15	interrelationship	interrelationship	NOUN
fnp-4366	568	16	may	may	AUX
fnp-4366	568	17	serve	serve	VERB
fnp-4366	568	18	as	as	ADP
fnp-4366	568	19	a	a	DET
fnp-4366	568	20	major	major	ADJ
fnp-4366	568	21	driver	driver	NOUN
fnp-4366	568	22	of	of	ADP
fnp-4366	568	23	the	the	DET
fnp-4366	568	24	disease	disease	NOUN
fnp-4366	568	25	pathology	pathology	NOUN
fnp-4366	568	26	.	.	PUNCT
fnp-4366	569	1	in	in	ADP
fnp-4366	569	2	view	view	NOUN
fnp-4366	569	3	of	of	ADP
fnp-4366	569	4	the	the	DET
fnp-4366	569	5	lack	lack	NOUN
fnp-4366	569	6	of	of	ADP
fnp-4366	569	7	effective	effective	ADJ
fnp-4366	569	8	treatment	treatment	NOUN
fnp-4366	569	9	there	there	PRON
fnp-4366	569	10	is	be	VERB
fnp-4366	569	11	an	an	DET
fnp-4366	569	12	urgent	urgent	ADJ
fnp-4366	569	13	need	need	NOUN
fnp-4366	569	14	for	for	ADP
fnp-4366	569	15	useful	useful	ADJ
fnp-4366	569	16	model	model	NOUN
fnp-4366	569	17	systems	system	NOUN
fnp-4366	569	18	that	that	PRON
fnp-4366	569	19	reflect	reflect	VERB
fnp-4366	569	20	the	the	DET
fnp-4366	569	21	presumed	presume	VERB
fnp-4366	569	22	pathomechanisms	pathomechanism	NOUN
fnp-4366	569	23	.	.	PUNCT
fnp-4366	570	1	a	a	DET
fnp-4366	570	2	reliable	reliable	ADJ
fnp-4366	570	3	animal	animal	NOUN
fnp-4366	570	4	model	model	NOUN
fnp-4366	570	5	for	for	ADP
fnp-4366	570	6	chronic	chronic	ADJ
fnp-4366	570	7	inflammatory	inflammatory	ADJ
fnp-4366	570	8	and	and	CCONJ
fnp-4366	570	9	degenerative	degenerative	ADJ
fnp-4366	570	10	features	feature	NOUN
fnp-4366	570	11	as	as	ADP
fnp-4366	570	12	in	in	ADP
fnp-4366	570	13	ibm	ibm	PROPN
fnp-4366	570	14	has	have	AUX
fnp-4366	570	15	not	not	PART
fnp-4366	570	16	been	be	AUX
fnp-4366	570	17	available	available	ADJ
fnp-4366	570	18	.	.	PUNCT
fnp-4366	571	1	methods	method	NOUN
fnp-4366	571	2	/	/	SYM
fnp-4366	571	3	results	result	NOUN
fnp-4366	571	4	:	:	PUNCT
fnp-4366	571	5	here	here	ADV
fnp-4366	571	6	,	,	PUNCT
fnp-4366	571	7	we	we	PRON
fnp-4366	571	8	established	establish	VERB
fnp-4366	571	9	mouse	mouse	NOUN
fnp-4366	571	10	models	model	NOUN
fnp-4366	571	11	with	with	ADP
fnp-4366	571	12	lymphotoxin	lymphotoxin	NOUN
fnp-4366	571	13	expression	expression	NOUN
fnp-4366	571	14	-	-	PUNCT
fnp-4366	571	15	driven	drive	VERB
fnp-4366	571	16	chronic	chronic	ADJ
fnp-4366	571	17	inflammation	inflammation	NOUN
fnp-4366	571	18	of	of	ADP
fnp-4366	571	19	skeletal	skeletal	ADJ
fnp-4366	571	20	muscle	muscle	NOUN
fnp-4366	571	21	and	and	CCONJ
fnp-4366	571	22	with	with	ADP
fnp-4366	571	23	impaired	impaired	ADJ
fnp-4366	571	24	autophagy	autophagy	NOUN
fnp-4366	571	25	due	due	ADP
fnp-4366	571	26	to	to	ADP
fnp-4366	571	27	muscle	muscle	NOUN
fnp-4366	571	28	cell	cell	NOUN
fnp-4366	571	29	specific	specific	ADJ
fnp-4366	571	30	atg5	atg5	NOUN
fnp-4366	571	31	-	-	PUNCT
fnp-4366	571	32	knockout	knockout	NOUN
fnp-4366	571	33	.	.	PUNCT
fnp-4366	572	1	both	both	DET
fnp-4366	572	2	conditions	condition	NOUN
fnp-4366	572	3	alone	alone	ADV
fnp-4366	572	4	induced	induce	VERB
fnp-4366	572	5	weakness	weakness	NOUN
fnp-4366	572	6	and	and	CCONJ
fnp-4366	572	7	muscular	muscular	ADJ
fnp-4366	572	8	atrophy	atrophy	NOUN
fnp-4366	572	9	.	.	PUNCT
fnp-4366	573	1	gene	gene	NOUN
fnp-4366	573	2	expression	expression	NOUN
fnp-4366	573	3	analysis	analysis	NOUN
fnp-4366	573	4	showed	show	VERB
fnp-4366	573	5	that	that	SCONJ
fnp-4366	573	6	,	,	PUNCT
fnp-4366	573	7	while	while	SCONJ
fnp-4366	573	8	chronic	chronic	ADJ
fnp-4366	573	9	inflammation	inflammation	NOUN
fnp-4366	573	10	alone	alone	ADV
fnp-4366	573	11	drives	drive	VERB
fnp-4366	573	12	endoplasmic	endoplasmic	ADJ
fnp-4366	573	13	reticulum	reticulum	NOUN
fnp-4366	573	14	stress	stress	NOUN
fnp-4366	573	15	and	and	CCONJ
fnp-4366	573	16	alters	alter	VERB
fnp-4366	573	17	autophagy/	autophagy/	NUM
fnp-4366	573	18	proteostasis	proteostasis	NOUN
fnp-4366	573	19	,	,	PUNCT
fnp-4366	573	20	autophagy	autophagy	ADJ
fnp-4366	573	21	disruption	disruption	NOUN
fnp-4366	573	22	alone	alone	ADV
fnp-4366	573	23	induces	induce	VERB
fnp-4366	573	24	a	a	DET
fnp-4366	573	25	pro	pro	ADJ
fnp-4366	573	26	-	-	ADJ
fnp-4366	573	27	inflammatory	inflammatory	ADJ
fnp-4366	573	28	state	state	NOUN
fnp-4366	573	29	.	.	PUNCT
fnp-4366	574	1	this	this	PRON
fnp-4366	574	2	suggests	suggest	VERB
fnp-4366	574	3	that	that	SCONJ
fnp-4366	574	4	both	both	PRON
fnp-4366	574	5	,	,	PUNCT
fnp-4366	574	6	inflammation	inflammation	NOUN
fnp-4366	574	7	and	and	CCONJ
fnp-4366	574	8	autophagy	autophagy	ADJ
fnp-4366	574	9	disruption	disruption	NOUN
fnp-4366	574	10	are	be	AUX
fnp-4366	574	11	interdependent	interdependent	ADJ
fnp-4366	574	12	in	in	ADP
fnp-4366	574	13	ibm	ibm	PROPN
fnp-4366	574	14	pathogenesis	pathogenesis	NOUN
fnp-4366	574	15	.	.	PUNCT
fnp-4366	575	1	only	only	ADV
fnp-4366	575	2	when	when	SCONJ
fnp-4366	575	3	we	we	PRON
fnp-4366	575	4	genetically	genetically	ADV
fnp-4366	575	5	combined	combine	VERB
fnp-4366	575	6	transgene	transgene	NOUN
fnp-4366	575	7	-	-	PUNCT
fnp-4366	575	8	driven	drive	VERB
fnp-4366	575	9	inflammation	inflammation	NOUN
fnp-4366	575	10	with	with	ADP
fnp-4366	575	11	autophagy	autophagy	ADJ
fnp-4366	575	12	impairment	impairment	NOUN
fnp-4366	575	13	in	in	ADP
fnp-4366	575	14	mice	mouse	NOUN
fnp-4366	575	15	,	,	PUNCT
fnp-4366	575	16	skeletal	skeletal	ADJ
fnp-4366	575	17	muscle	muscle	NOUN
fnp-4366	575	18	fibers	fiber	NOUN
fnp-4366	575	19	displayed	display	VERB
fnp-4366	575	20	characteristic	characteristic	ADJ
fnp-4366	575	21	molecular	molecular	ADJ
fnp-4366	575	22	and	and	CCONJ
fnp-4366	575	23	neuropathological	neuropathological	ADJ
fnp-4366	575	24	features	feature	NOUN
fnp-4366	575	25	of	of	ADP
fnp-4366	575	26	ibm	ibm	PROPN
fnp-4366	575	27	,	,	PUNCT
fnp-4366	575	28	including	include	VERB
fnp-4366	575	29	protein	protein	NOUN
fnp-4366	575	30	aggregates	aggregate	NOUN
fnp-4366	575	31	with	with	ADP
fnp-4366	575	32	typical	typical	ADJ
fnp-4366	575	33	ultrastructural	ultrastructural	ADJ
fnp-4366	575	34	morphology	morphology	NOUN
fnp-4366	575	35	.	.	PUNCT
fnp-4366	576	1	given	give	VERB
fnp-4366	576	2	that	that	PRON
fnp-4366	576	3	human	human	ADJ
fnp-4366	576	4	ibm	ibm	PROPN
fnp-4366	576	5	is	be	AUX
fnp-4366	576	6	refractory	refractory	NOUN
fnp-4366	576	7	to	to	ADP
fnp-4366	576	8	established	establish	VERB
fnp-4366	576	9	drugs	drug	NOUN
fnp-4366	576	10	,	,	PUNCT
fnp-4366	576	11	we	we	PRON
fnp-4366	576	12	aimed	aim	VERB
fnp-4366	576	13	to	to	PART
fnp-4366	576	14	mirror	mirror	VERB
fnp-4366	576	15	recent	recent	ADJ
fnp-4366	576	16	treatment	treatment	NOUN
fnp-4366	576	17	failures	failure	NOUN
fnp-4366	576	18	and	and	CCONJ
fnp-4366	576	19	identify	identify	VERB
fnp-4366	576	20	the	the	DET
fnp-4366	576	21	underlying	underlie	VERB
fnp-4366	576	22	mechanisms	mechanism	NOUN
fnp-4366	576	23	by	by	ADP
fnp-4366	576	24	subjecting	subject	VERB
fnp-4366	576	25	four	four	NUM
fnp-4366	576	26	months	month	NOUN
fnp-4366	576	27	-	-	PUNCT
fnp-4366	576	28	old	old	ADJ
fnp-4366	576	29	myositis	myositis	NOUN
fnp-4366	576	30	mice	mouse	NOUN
fnp-4366	576	31	to	to	ADP
fnp-4366	576	32	corticosteroids	corticosteroid	NOUN
fnp-4366	576	33	,	,	PUNCT
fnp-4366	576	34	anti	anti	ADJ
fnp-4366	576	35	-	-	ADJ
fnp-4366	576	36	cd52	cd52	PROPN
fnp-4366	576	37	or	or	CCONJ
fnp-4366	576	38	anti	anti	ADJ
fnp-4366	576	39	-	-	ADJ
fnp-4366	576	40	thy1.2	thy1.2	ADJ
fnp-4366	576	41	antibodies	antibody	NOUN
fnp-4366	576	42	to	to	ADP
fnp-4366	576	43	deplete	deplete	NOUN
fnp-4366	576	44	lymphocytes	lymphocyte	NOUN
fnp-4366	576	45	,	,	PUNCT
fnp-4366	576	46	or	or	CCONJ
fnp-4366	576	47	by	by	ADP
fnp-4366	576	48	blocking	block	VERB
fnp-4366	576	49	lymphotoxin	lymphotoxin	NOUN
fnp-4366	576	50	beta	beta	NOUN
fnp-4366	576	51	-	-	PUNCT
fnp-4366	576	52	receptor	receptor	NOUN
fnp-4366	576	53	signaling	signaling	NOUN
fnp-4366	576	54	.	.	PUNCT
fnp-4366	577	1	none	none	NOUN
fnp-4366	577	2	of	of	ADP
fnp-4366	577	3	these	these	DET
fnp-4366	577	4	treatments	treatment	NOUN
fnp-4366	577	5	was	be	AUX
fnp-4366	577	6	able	able	ADJ
fnp-4366	577	7	to	to	PART
fnp-4366	577	8	significantly	significantly	ADV
fnp-4366	577	9	improve	improve	VERB
fnp-4366	577	10	muscular	muscular	ADJ
fnp-4366	577	11	performance	performance	NOUN
fnp-4366	577	12	of	of	ADP
fnp-4366	577	13	the	the	DET
fnp-4366	577	14	mice	mouse	NOUN
fnp-4366	577	15	or	or	CCONJ
fnp-4366	577	16	expression	expression	NOUN
fnp-4366	577	17	profiles	profile	NOUN
fnp-4366	577	18	of	of	ADP
fnp-4366	577	19	molecular	molecular	ADJ
fnp-4366	577	20	indicators	indicator	NOUN
fnp-4366	577	21	of	of	ADP
fnp-4366	577	22	muscle	muscle	NOUN
fnp-4366	577	23	pathology	pathology	NOUN
fnp-4366	577	24	.	.	PUNCT
fnp-4366	578	1	this	this	PRON
fnp-4366	578	2	suggests	suggest	VERB
fnp-4366	578	3	that	that	SCONJ
fnp-4366	578	4	,	,	PUNCT
fnp-4366	578	5	once	once	ADV
fnp-4366	578	6	established	establish	VERB
fnp-4366	578	7	,	,	PUNCT
fnp-4366	578	8	ibm	ibm	PROPN
fnp-4366	578	9	-	-	PUNCT
fnp-4366	578	10	like	like	ADJ
fnp-4366	578	11	pathology	pathology	NOUN
fnp-4366	578	12	can	can	AUX
fnp-4366	578	13	not	not	PART
fnp-4366	578	14	be	be	AUX
fnp-4366	578	15	reverted	revert	VERB
fnp-4366	578	16	or	or	CCONJ
fnp-4366	578	17	prevented	prevent	VERB
fnp-4366	578	18	from	from	ADP
fnp-4366	578	19	progression	progression	NOUN
fnp-4366	578	20	,	,	PUNCT
fnp-4366	578	21	but	but	CCONJ
fnp-4366	578	22	is	be	AUX
fnp-4366	578	23	a	a	DET
fnp-4366	578	24	self	self	NOUN
fnp-4366	578	25	-	-	PUNCT
fnp-4366	578	26	perpetuating	perpetuate	VERB
fnp-4366	578	27	condition	condition	NOUN
fnp-4366	578	28	.	.	PUNCT
fnp-4366	579	1	conclusions	conclusion	NOUN
fnp-4366	579	2	:	:	PUNCT
fnp-4366	579	3	in	in	ADP
fnp-4366	579	4	summary	summary	NOUN
fnp-4366	579	5	,	,	PUNCT
fnp-4366	579	6	the	the	DET
fnp-4366	579	7	data	datum	NOUN
fnp-4366	579	8	provide	provide	VERB
fnp-4366	579	9	unique	unique	ADJ
fnp-4366	579	10	evidence	evidence	NOUN
fnp-4366	579	11	that	that	SCONJ
fnp-4366	579	12	inflammation	inflammation	NOUN
fnp-4366	579	13	and	and	CCONJ
fnp-4366	579	14	autophagy	autophagy	ADJ
fnp-4366	579	15	disruption	disruption	NOUN
fnp-4366	579	16	are	be	AUX
fnp-4366	579	17	intertwined	intertwine	VERB
fnp-4366	579	18	in	in	ADP
fnp-4366	579	19	ibm	ibm	PROPN
fnp-4366	579	20	-	-	PUNCT
fnp-4366	579	21	like	like	ADJ
fnp-4366	579	22	muscular	muscular	ADJ
fnp-4366	579	23	pathology	pathology	NOUN
fnp-4366	579	24	.	.	PUNCT
fnp-4366	580	1	it	it	PRON
fnp-4366	580	2	can	can	AUX
fnp-4366	580	3	be	be	AUX
fnp-4366	580	4	expected	expect	VERB
fnp-4366	580	5	that	that	SCONJ
fnp-4366	580	6	this	this	DET
fnp-4366	580	7	novel	novel	ADJ
fnp-4366	580	8	mouse	mouse	NOUN
fnp-4366	580	9	model	model	NOUN
fnp-4366	580	10	will	will	AUX
fnp-4366	580	11	substantially	substantially	ADV
fnp-4366	580	12	further	further	VERB
fnp-4366	580	13	our	our	PRON
fnp-4366	580	14	effort	effort	NOUN
fnp-4366	580	15	to	to	PART
fnp-4366	580	16	identify	identify	VERB
fnp-4366	580	17	better	well	ADJ
fnp-4366	580	18	treatment	treatment	NOUN
fnp-4366	580	19	modalities	modality	NOUN
fnp-4366	580	20	for	for	ADP
fnp-4366	580	21	ibm	ibm	PROPN
fnp-4366	580	22	in	in	ADP
fnp-4366	580	23	the	the	DET
fnp-4366	580	24	future	future	NOUN
fnp-4366	580	25	.	.	PUNCT
fnp-4366	580	26	  	  	SPACE
fnp-4366	581	1	5.05	5.05	NUM
fnp-4366	581	2	free	free	ADJ
fnp-4366	581	3	neuropathol	neuropathol	NOUN
fnp-4366	581	4	3:20:56	3:20:56	NUM
fnp-4366	581	5	novel	novel	NOUN
fnp-4366	581	6	form	form	NOUN
fnp-4366	581	7	of	of	ADP
fnp-4366	581	8	congenital	congenital	ADJ
fnp-4366	581	9	myopathy	myopathy	NOUN
fnp-4366	581	10	caused	cause	VERB
fnp-4366	581	11	by	by	ADP
fnp-4366	581	12	bi	bi	ADJ
fnp-4366	581	13	-	-	ADJ
fnp-4366	581	14	allelic	allelic	ADJ
fnp-4366	581	15	mutations	mutation	NOUN
fnp-4366	581	16	in	in	ADP
fnp-4366	581	17	uncoordinated	uncoordinated	ADJ
fnp-4366	581	18	mutant	mutant	ADJ
fnp-4366	581	19	number-45	number-45	PROPN
fnp-4366	581	20	myosin	myosin	PROPN
fnp-4366	581	21	chaperone	chaperone	PROPN
fnp-4366	581	22	b	b	PROPN
fnp-4366	581	23	sebahattin	sebahattin	NOUN
fnp-4366	581	24	cirak1	cirak1	PROPN
fnp-4366	581	25	1	1	NUM
fnp-4366	581	26	uniklinik	uniklinik	X
fnp-4366	581	27	ulm	ulm	PROPN
fnp-4366	581	28	,	,	PUNCT
fnp-4366	581	29	klinik	klinik	PROPN
fnp-4366	581	30	für	für	PROPN
fnp-4366	581	31	kinder	kind	ADJ
fnp-4366	581	32	-	-	PUNCT
fnp-4366	581	33	und	und	NOUN
fnp-4366	581	34	jugendmedizin	jugendmedizin	PROPN
fnp-4366	581	35	,	,	PUNCT
fnp-4366	581	36	sozialpädiatrisches	sozialpädiatrisches	PROPN
fnp-4366	581	37	zentrum	zentrum	PROPN
fnp-4366	581	38	und	und	PROPN
fnp-4366	581	39	pädiatrische	pädiatrische	PROPN
fnp-4366	581	40	neurologie	neurologie	PROPN
fnp-4366	581	41	mit	mit	PROPN
fnp-4366	581	42	stoffwechsel	stoffwechsel	PROPN
fnp-4366	581	43	,	,	PUNCT
fnp-4366	581	44	ulm	ulm	PROPN
fnp-4366	581	45	,	,	PUNCT
fnp-4366	581	46	deutschland	deutschland	NOUN
fnp-4366	581	47	background	background	NOUN
fnp-4366	581	48	:	:	PUNCT
fnp-4366	581	49	congenital	congenital	ADJ
fnp-4366	581	50	myopathies	myopathy	NOUN
fnp-4366	581	51	(	(	PUNCT
fnp-4366	581	52	cm	cm	NOUN
fnp-4366	581	53	)	)	PUNCT
fnp-4366	581	54	form	form	NOUN
fnp-4366	581	55	a	a	DET
fnp-4366	581	56	genetically	genetically	ADV
fnp-4366	581	57	heterogeneous	heterogeneous	ADJ
fnp-4366	581	58	group	group	NOUN
fnp-4366	581	59	of	of	ADP
fnp-4366	581	60	disorders	disorder	NOUN
fnp-4366	581	61	,	,	PUNCT
fnp-4366	581	62	only	only	ADV
fnp-4366	581	63	60	60	NUM
fnp-4366	581	64	%	%	NOUN
fnp-4366	581	65	can	can	AUX
fnp-4366	581	66	be	be	AUX
fnp-4366	581	67	genetically	genetically	ADV
fnp-4366	581	68	solved	solve	VERB
fnp-4366	581	69	.	.	PUNCT
fnp-4366	582	1	aims	aim	NOUN
fnp-4366	582	2	:	:	PUNCT
fnp-4366	582	3	discovery	discovery	NOUN
fnp-4366	582	4	of	of	ADP
fnp-4366	582	5	novel	novel	NOUN
fnp-4366	582	6	genetically	genetically	ADV
fnp-4366	582	7	defined	define	VERB
fnp-4366	582	8	myopathies	myopathy	NOUN
fnp-4366	582	9	.	.	PUNCT
fnp-4366	583	1	question	question	NOUN
fnp-4366	583	2	:	:	PUNCT
fnp-4366	583	3	deciphering	decipher	VERB
fnp-4366	583	4	the	the	DET
fnp-4366	583	5	genomic	genomic	ADJ
fnp-4366	583	6	landscape	landscape	NOUN
fnp-4366	583	7	of	of	ADP
fnp-4366	583	8	congenital	congenital	ADJ
fnp-4366	583	9	myopathies	myopathy	NOUN
fnp-4366	583	10	.	.	PUNCT
fnp-4366	584	1	methods	method	NOUN
fnp-4366	584	2	:	:	PUNCT
fnp-4366	584	3	we	we	PRON
fnp-4366	584	4	recruited	recruit	VERB
fnp-4366	584	5	an	an	DET
fnp-4366	584	6	11	11	NUM
fnp-4366	584	7	-	-	PUNCT
fnp-4366	584	8	year	year	NOUN
fnp-4366	584	9	old	old	ADJ
fnp-4366	584	10	male	male	NOUN
fnp-4366	584	11	of	of	ADP
fnp-4366	584	12	consanguineous	consanguineous	ADJ
fnp-4366	584	13	parents	parent	NOUN
fnp-4366	584	14	,	,	PUNCT
fnp-4366	584	15	presenting	present	VERB
fnp-4366	584	16	with	with	ADP
fnp-4366	584	17	proximal	proximal	ADJ
fnp-4366	584	18	weakness	weakness	NOUN
fnp-4366	584	19	,	,	PUNCT
fnp-4366	584	20	gower	gower	PROPN
fnp-4366	584	21	's	's	PART
fnp-4366	584	22	sign	sign	NOUN
fnp-4366	584	23	,	,	PUNCT
fnp-4366	584	24	without	without	ADP
fnp-4366	584	25	cardiomyopathy	cardiomyopathy	ADJ
fnp-4366	584	26	with	with	ADP
fnp-4366	584	27	a	a	DET
fnp-4366	584	28	stable	stable	ADJ
fnp-4366	584	29	disease	disease	NOUN
fnp-4366	584	30	course	course	NOUN
fnp-4366	584	31	.	.	PUNCT
fnp-4366	585	1	we	we	PRON
fnp-4366	585	2	performed	perform	VERB
fnp-4366	585	3	exome	exome	NOUN
fnp-4366	585	4	sequencing	sequencing	NOUN
fnp-4366	585	5	and	and	CCONJ
fnp-4366	585	6	data	datum	NOUN
fnp-4366	585	7	analysis	analysis	NOUN
fnp-4366	585	8	was	be	AUX
fnp-4366	585	9	performed	perform	VERB
fnp-4366	585	10	with	with	ADP
fnp-4366	585	11	our	our	PRON
fnp-4366	585	12	in	in	ADP
fnp-4366	585	13	-	-	PUNCT
fnp-4366	585	14	house	house	NOUN
fnp-4366	585	15	software	software	NOUN
fnp-4366	585	16	varbank2	varbank2	NOUN
fnp-4366	585	17	according	accord	VERB
fnp-4366	585	18	to	to	ADP
fnp-4366	585	19	an	an	DET
fnp-4366	585	20	autosomal	autosomal	ADJ
fnp-4366	585	21	recessive	recessive	ADJ
fnp-4366	585	22	inheritance	inheritance	NOUN
fnp-4366	585	23	.	.	PUNCT
fnp-4366	586	1	we	we	PRON
fnp-4366	586	2	investigated	investigate	VERB
fnp-4366	586	3	the	the	DET
fnp-4366	586	4	effect	effect	NOUN
fnp-4366	586	5	of	of	ADP
fnp-4366	586	6	the	the	DET
fnp-4366	586	7	missense	missense	NOUN
fnp-4366	586	8	mutation	mutation	NOUN
fnp-4366	586	9	by	by	ADP
fnp-4366	586	10	complementation	complementation	NOUN
fnp-4366	586	11	assay	assay	NOUN
fnp-4366	586	12	on	on	ADP
fnp-4366	586	13	the	the	DET
fnp-4366	586	14	zebrafish	zebrafish	ADJ
fnp-4366	586	15	steif	steif	NOUN
fnp-4366	586	16	mutant	mutant	NOUN
fnp-4366	586	17	,	,	PUNCT
fnp-4366	586	18	an	an	DET
fnp-4366	586	19	unc-45b	unc-45b	NUM
fnp-4366	586	20	loss	loss	NOUN
fnp-4366	586	21	-	-	PUNCT
fnp-4366	586	22	of	of	ADP
fnp-4366	586	23	-	-	PUNCT
fnp-4366	586	24	function	function	NOUN
fnp-4366	586	25	model	model	NOUN
fnp-4366	586	26	.	.	PUNCT
fnp-4366	587	1	results	result	NOUN
fnp-4366	587	2	:	:	PUNCT
fnp-4366	587	3	we	we	PRON
fnp-4366	587	4	have	have	AUX
fnp-4366	587	5	discovered	discover	VERB
fnp-4366	587	6	and	and	CCONJ
fnp-4366	587	7	published	publish	VERB
fnp-4366	587	8	a	a	DET
fnp-4366	587	9	novel	novel	NOUN
fnp-4366	587	10	genetically	genetically	ADV
fnp-4366	587	11	defined	define	VERB
fnp-4366	587	12	form	form	NOUN
fnp-4366	587	13	of	of	ADP
fnp-4366	587	14	cm	cm	NOUN
fnp-4366	587	15	due	due	ADP
fnp-4366	587	16	to	to	ADP
fnp-4366	587	17	a	a	DET
fnp-4366	587	18	novel	novel	ADJ
fnp-4366	587	19	homozygous	homozygous	ADJ
fnp-4366	587	20	missense	missense	NOUN
fnp-4366	587	21	mutation	mutation	NOUN
fnp-4366	587	22	in	in	ADP
fnp-4366	587	23	unc45b	unc45b	PRON
fnp-4366	587	24	(	(	PUNCT
fnp-4366	587	25	nm_173167.2	nm_173167.2	NOUN
fnp-4366	587	26	:	:	PUNCT
fnp-4366	587	27	c.2261g	c.2261g	NOUN
fnp-4366	587	28	>	>	X
fnp-4366	587	29	a	a	PRON
fnp-4366	587	30	,	,	PUNCT
fnp-4366	587	31	p.arg754gln	p.arg754gln	PROPN
fnp-4366	587	32	)	)	PUNCT
fnp-4366	587	33	also	also	ADV
fnp-4366	587	34	co	co	VERB
fnp-4366	587	35	-	-	ADJ
fnp-4366	587	36	segregating	segregating	ADJ
fnp-4366	587	37	in	in	ADP
fnp-4366	587	38	the	the	DET
fnp-4366	587	39	family	family	NOUN
fnp-4366	587	40	with	with	ADP
fnp-4366	587	41	three	three	NUM
fnp-4366	587	42	healthy	healthy	ADJ
fnp-4366	587	43	siblings	sibling	NOUN
fnp-4366	587	44	(	(	PUNCT
fnp-4366	587	45	dafsari	dafsari	ADV
fnp-4366	587	46	et	et	PROPN
fnp-4366	587	47	al	al	PROPN
fnp-4366	587	48	.	.	PROPN
fnp-4366	587	49	,	,	PUNCT
fnp-4366	587	50	2019	2019	NUM
fnp-4366	587	51	)	)	PUNCT
fnp-4366	587	52	.	.	PUNCT
fnp-4366	588	1	in	in	ADP
fnp-4366	588	2	our	our	PRON
fnp-4366	588	3	patient	patient	NOUN
fnp-4366	588	4	's	's	PART
fnp-4366	588	5	muscle	muscle	NOUN
fnp-4366	588	6	biopsy	biopsy	NOUN
fnp-4366	588	7	,	,	PUNCT
fnp-4366	588	8	core	core	NOUN
fnp-4366	588	9	-	-	PUNCT
fnp-4366	588	10	like	like	ADJ
fnp-4366	588	11	structures	structure	NOUN
fnp-4366	588	12	were	be	AUX
fnp-4366	588	13	detected	detect	VERB
fnp-4366	588	14	mainly	mainly	ADV
fnp-4366	588	15	in	in	ADP
fnp-4366	588	16	the	the	DET
fnp-4366	588	17	center	center	NOUN
fnp-4366	588	18	of	of	ADP
fnp-4366	588	19	muscle	muscle	NOUN
fnp-4366	588	20	fibers	fiber	NOUN
fnp-4366	588	21	in	in	ADP
fnp-4366	588	22	nadh	nadh	PROPN
fnp-4366	588	23	histochemistry	histochemistry	PROPN
fnp-4366	588	24	.	.	PUNCT
fnp-4366	589	1	electron	electron	NOUN
fnp-4366	589	2	microscopy	microscopy	NOUN
fnp-4366	589	3	showed	show	VERB
fnp-4366	589	4	numerous	numerous	ADJ
fnp-4366	589	5	focal	focal	ADJ
fnp-4366	589	6	core	core	NOUN
fnp-4366	589	7	-	-	PUNCT
fnp-4366	589	8	like	like	ADJ
fnp-4366	589	9	alterations	alteration	NOUN
fnp-4366	589	10	of	of	ADP
fnp-4366	589	11	myofibrillar	myofibrillar	ADJ
fnp-4366	589	12	architecture	architecture	NOUN
fnp-4366	589	13	with	with	ADP
fnp-4366	589	14	z	z	NOUN
fnp-4366	589	15	-	-	PUNCT
fnp-4366	589	16	bands	band	NOUN
fnp-4366	589	17	streaming	streaming	NOUN
fnp-4366	589	18	.	.	PUNCT
fnp-4366	590	1	conclusions	conclusion	NOUN
fnp-4366	590	2	:	:	PUNCT
fnp-4366	590	3	three	three	NUM
fnp-4366	590	4	isoforms	isoform	NOUN
fnp-4366	590	5	of	of	ADP
fnp-4366	590	6	unc45b	unc45b	PRON
fnp-4366	590	7	are	be	AUX
fnp-4366	590	8	highly	highly	ADV
fnp-4366	590	9	expressed	express	VERB
fnp-4366	590	10	in	in	ADP
fnp-4366	590	11	skeletal	skeletal	ADJ
fnp-4366	590	12	muscle	muscle	NOUN
fnp-4366	590	13	,	,	PUNCT
fnp-4366	590	14	only	only	ADV
fnp-4366	590	15	one	one	NUM
fnp-4366	590	16	also	also	ADV
fnp-4366	590	17	in	in	ADP
fnp-4366	590	18	cardiac	cardiac	ADJ
fnp-4366	590	19	muscle	muscle	NOUN
fnp-4366	590	20	.	.	PUNCT
fnp-4366	591	1	due	due	ADP
fnp-4366	591	2	to	to	ADP
fnp-4366	591	3	its	its	PRON
fnp-4366	591	4	high	high	ADJ
fnp-4366	591	5	evolutionary	evolutionary	ADJ
fnp-4366	591	6	conservation	conservation	NOUN
fnp-4366	591	7	throughout	throughout	ADP
fnp-4366	591	8	species	specie	NOUN
fnp-4366	591	9	,	,	PUNCT
fnp-4366	591	10	a	a	DET
fnp-4366	591	11	loss	loss	NOUN
fnp-4366	591	12	of	of	ADP
fnp-4366	591	13	unc45	unc45	PROPN
fnp-4366	591	14	results	result	NOUN
fnp-4366	591	15	in	in	ADP
fnp-4366	591	16	different	different	ADJ
fnp-4366	591	17	pathological	pathological	ADJ
fnp-4366	591	18	conditions	condition	NOUN
fnp-4366	591	19	in	in	ADP
fnp-4366	591	20	various	various	ADJ
fnp-4366	591	21	species	specie	NOUN
fnp-4366	591	22	:	:	PUNCT
fnp-4366	591	23	a	a	DET
fnp-4366	591	24	knockdown	knockdown	NOUN
fnp-4366	591	25	of	of	ADP
fnp-4366	591	26	unc-45	unc-45	NOUN
fnp-4366	591	27	resulted	result	VERB
fnp-4366	591	28	in	in	ADP
fnp-4366	591	29	dilated	dilated	ADJ
fnp-4366	591	30	cardiomyopathy	cardiomyopathy	ADJ
fnp-4366	591	31	and	and	CCONJ
fnp-4366	591	32	a	a	DET
fnp-4366	591	33	reduced	reduced	ADJ
fnp-4366	591	34	muscle	muscle	NOUN
fnp-4366	591	35	contractility	contractility	NOUN
fnp-4366	591	36	in	in	ADP
fnp-4366	591	37	d.	d.	PROPN
fnp-4366	591	38	melanogaster	melanogaster	NOUN
fnp-4366	591	39	.	.	PUNCT
fnp-4366	592	1	similarly	similarly	ADV
fnp-4366	592	2	,	,	PUNCT
fnp-4366	592	3	in	in	ADP
fnp-4366	592	4	unc-45b	unc-45b	NUM
fnp-4366	592	5	knockdown	knockdown	VERB
fnp-4366	592	6	zebrafish	zebrafish	ADJ
fnp-4366	592	7	and	and	CCONJ
fnp-4366	592	8	also	also	ADV
fnp-4366	592	9	in	in	ADP
fnp-4366	592	10	steif	steif	ADJ
fnp-4366	592	11	mutants	mutant	NOUN
fnp-4366	592	12	,	,	PUNCT
fnp-4366	592	13	disrupted	disrupt	VERB
fnp-4366	592	14	myofibrillogenesis	myofibrillogenesis	NOUN
fnp-4366	592	15	associated	associate	VERB
fnp-4366	592	16	cardiac	cardiac	ADJ
fnp-4366	592	17	dysfunction	dysfunction	NOUN
fnp-4366	592	18	and	and	CCONJ
fnp-4366	592	19	paralysis	paralysis	NOUN
fnp-4366	592	20	was	be	AUX
fnp-4366	592	21	observed	observe	VERB
fnp-4366	592	22	.	.	PUNCT
fnp-4366	593	1	injection	injection	NOUN
fnp-4366	593	2	of	of	ADP
fnp-4366	593	3	mutant	mutant	NOUN
fnp-4366	593	4	unc-45b	unc-45b	NUM
fnp-4366	593	5	mrna	mrna	PROPN
fnp-4366	593	6	did	do	AUX
fnp-4366	593	7	not	not	PART
fnp-4366	593	8	rescue	rescue	VERB
fnp-4366	593	9	the	the	DET
fnp-4366	593	10	steif	steif	NOUN
fnp-4366	593	11	mutant	mutant	NOUN
fnp-4366	593	12	in	in	ADP
fnp-4366	593	13	contrast	contrast	NOUN
fnp-4366	593	14	to	to	ADP
fnp-4366	593	15	wt	wt	PROPN
fnp-4366	593	16	mrna	mrna	PROPN
fnp-4366	593	17	confirming	confirm	VERB
fnp-4366	593	18	the	the	DET
fnp-4366	593	19	pathogenicity	pathogenicity	NOUN
fnp-4366	593	20	of	of	ADP
fnp-4366	593	21	the	the	DET
fnp-4366	593	22	missense	missense	NOUN
fnp-4366	593	23	mutation	mutation	NOUN
fnp-4366	593	24	.	.	PUNCT
fnp-4366	593	25	  	  	SPACE
fnp-4366	594	1	6	6	NUM
fnp-4366	594	2	.	.	PUNCT
fnp-4366	594	3	free	free	ADJ
fnp-4366	594	4	topics	topic	NOUN
fnp-4366	594	5	6.01	6.01	NUM
fnp-4366	594	6	free	free	ADJ
fnp-4366	594	7	neuropathol	neuropathol	NOUN
fnp-4366	594	8	3:20:57	3:20:57	NUM
fnp-4366	594	9	deep	deep	ADJ
fnp-4366	594	10	genotype	genotype	NOUN
fnp-4366	594	11	-	-	PUNCT
fnp-4366	594	12	phenotype	phenotype	NOUN
fnp-4366	594	13	analysis	analysis	NOUN
fnp-4366	594	14	of	of	ADP
fnp-4366	594	15	focal	focal	ADJ
fnp-4366	594	16	cortical	cortical	ADJ
fnp-4366	594	17	dysplasia	dysplasia	NOUN
fnp-4366	594	18	type	type	NOUN
fnp-4366	594	19	2	2	NUM
fnp-4366	594	20	differentiates	differentiate	NOUN
fnp-4366	594	21	between	between	ADP
fnp-4366	594	22	a	a	DET
fnp-4366	594	23	gator	gator	NOUN
fnp-4366	594	24	-	-	PUNCT
fnp-4366	594	25	positive	positive	ADJ
fnp-4366	594	26	autophagy	autophagy	NOUN
fnp-4366	594	27	altered	alter	VERB
fnp-4366	594	28	subtype	subtype	NOUN
fnp-4366	594	29	2a	2a	NUM
fnp-4366	594	30	and	and	CCONJ
fnp-4366	594	31	mtor	mtor	NOUN
fnp-4366	594	32	-	-	PUNCT
fnp-4366	594	33	positive	positive	ADJ
fnp-4366	594	34	migration	migration	NOUN
fnp-4366	594	35	deficit	deficit	NOUN
fnp-4366	594	36	subtype	subtype	NOUN
fnp-4366	594	37	2b	2b	NUM
fnp-4366	594	38	jonas	jonas	PROPN
fnp-4366	594	39	honke1	honke1	PROPN
fnp-4366	594	40	,	,	PUNCT
fnp-4366	594	41	lucas	lucas	PROPN
fnp-4366	594	42	hoffmann1	hoffmann1	PROPN
fnp-4366	594	43	,	,	PUNCT
fnp-4366	594	44	roland	roland	PROPN
fnp-4366	594	45	coras1	coras1	PROPN
fnp-4366	594	46	,	,	PUNCT
fnp-4366	594	47	javier	javier	PROPN
fnp-4366	594	48	a.	a.	PROPN
fnp-4366	594	49	lópez	lópez	PROPN
fnp-4366	594	50	-	-	PUNCT
fnp-4366	594	51	rivera2,3,4	rivera2,3,4	PROPN
fnp-4366	594	52	,	,	PUNCT
fnp-4366	594	53	costin	costin	PROPN
fnp-4366	594	54	leu3,4,5,6	leu3,4,5,6	PROPN
fnp-4366	594	55	,	,	PUNCT
fnp-4366	594	56	dennis	dennis	PROPN
fnp-4366	594	57	lal3,4,5,6	lal3,4,5,6	PROPN
fnp-4366	594	58	,	,	PUNCT
fnp-4366	594	59	peter	peter	PROPN
fnp-4366	594	60	nürnberg6	nürnberg6	PROPN
fnp-4366	594	61	,	,	PUNCT
fnp-4366	594	62	tom	tom	PROPN
fnp-4366	594	63	pieper7	pieper7	PROPN
fnp-4366	594	64	,	,	PUNCT
fnp-4366	594	65	till	till	SCONJ
fnp-4366	594	66	hartlieb7	hartlieb7	NOUN
fnp-4366	594	67	,	,	PUNCT
fnp-4366	594	68	manfred	manfred	PROPN
fnp-4366	594	69	kudernatsch7	kudernatsch7	PROPN
fnp-4366	594	70	,	,	PUNCT
fnp-4366	594	71	christian	christian	PROPN
fnp-4366	594	72	g.	g.	PROPN
fnp-4366	594	73	bien8	bien8	PROPN
fnp-4366	594	74	,	,	PUNCT
fnp-4366	594	75	friedrich	friedrich	PROPN
fnp-4366	594	76	woermann8	woermann8	PROPN
fnp-4366	594	77	,	,	PUNCT
fnp-4366	594	78	thomas	thomas	PROPN
fnp-4366	594	79	cloppenborg8	cloppenborg8	PROPN
fnp-4366	594	80	,	,	PUNCT
fnp-4366	594	81	hajo	hajo	ADV
fnp-4366	594	82	hamer9	hamer9	PROPN
fnp-4366	594	83	,	,	PUNCT
fnp-4366	594	84	sebastian	sebastian	PROPN
fnp-4366	594	85	brandner10	brandner10	PROPN
fnp-4366	594	86	,	,	PUNCT
fnp-4366	594	87	karl	karl	PROPN
fnp-4366	594	88	rössler11	rössler11	PROPN
fnp-4366	594	89	,	,	PUNCT
fnp-4366	594	90	arnd	arnd	PROPN
fnp-4366	594	91	dörfler12	dörfler12	PROPN
fnp-4366	594	92	,	,	PUNCT
fnp-4366	594	93	stéphanie	stéphanie	PROPN
fnp-4366	594	94	baulac13	baulac13	PROPN
fnp-4366	594	95	,	,	PUNCT
fnp-4366	594	96	sara	sara	PROPN
fnp-4366	594	97	baldassari13	baldassari13	PROPN
fnp-4366	594	98	,	,	PUNCT
fnp-4366	594	99	ingmar	ingmar	PROPN
fnp-4366	594	100	blümcke1,4	blümcke1,4	PROPN
fnp-4366	594	101	1	1	NUM
fnp-4366	594	102	department	department	NOUN
fnp-4366	594	103	of	of	ADP
fnp-4366	594	104	neuropathology	neuropathology	NOUN
fnp-4366	594	105	,	,	PUNCT
fnp-4366	594	106	universitätsklinikum	universitätsklinikum	ADJ
fnp-4366	594	107	erlangen	erlangen	PROPN
fnp-4366	594	108	,	,	PUNCT
fnp-4366	594	109	fau	fau	PROPN
fnp-4366	594	110	erlangen	erlangen	PROPN
fnp-4366	594	111	-	-	PUNCT
fnp-4366	594	112	nürnberg	nürnberg	PROPN
fnp-4366	594	113	,	,	PUNCT
fnp-4366	594	114	and	and	CCONJ
fnp-4366	594	115	partner	partner	NOUN
fnp-4366	594	116	of	of	ADP
fnp-4366	594	117	the	the	DET
fnp-4366	594	118	european	european	PROPN
fnp-4366	594	119	reference	reference	NOUN
fnp-4366	594	120	network	network	NOUN
fnp-4366	594	121	(	(	PUNCT
fnp-4366	594	122	ern	ern	PROPN
fnp-4366	594	123	)	)	PUNCT
fnp-4366	594	124	epicare	epicare	PROPN
fnp-4366	594	125	,	,	PUNCT
fnp-4366	594	126	erlangen	erlangen	PROPN
fnp-4366	594	127	,	,	PUNCT
fnp-4366	594	128	deutschland	deutschland	PROPN
fnp-4366	594	129	1	1	NUM
fnp-4366	594	130	department	department	NOUN
fnp-4366	594	131	of	of	ADP
fnp-4366	594	132	molecular	molecular	ADJ
fnp-4366	594	133	medicine	medicine	NOUN
fnp-4366	594	134	,	,	PUNCT
fnp-4366	594	135	cleveland	cleveland	PROPN
fnp-4366	594	136	clinic	clinic	PROPN
fnp-4366	594	137	lerner	lerner	PROPN
fnp-4366	594	138	college	college	PROPN
fnp-4366	594	139	of	of	ADP
fnp-4366	594	140	medicine	medicine	NOUN
fnp-4366	594	141	,	,	PUNCT
fnp-4366	594	142	case	case	NOUN
fnp-4366	594	143	western	western	PROPN
fnp-4366	594	144	reserve	reserve	PROPN
fnp-4366	594	145	university	university	PROPN
fnp-4366	594	146	,	,	PUNCT
fnp-4366	594	147	cleveland	cleveland	PROPN
fnp-4366	594	148	,	,	PUNCT
fnp-4366	594	149	united	united	PROPN
fnp-4366	594	150	states	states	PROPN
fnp-4366	594	151	1	1	NUM
fnp-4366	594	152	genomic	genomic	PROPN
fnp-4366	594	153	medicine	medicine	NOUN
fnp-4366	594	154	institute	institute	PROPN
fnp-4366	594	155	,	,	PUNCT
fnp-4366	594	156	lerner	lerner	PROPN
fnp-4366	594	157	research	research	PROPN
fnp-4366	594	158	institute	institute	PROPN
fnp-4366	594	159	,	,	PUNCT
fnp-4366	594	160	cleveland	cleveland	PROPN
fnp-4366	594	161	clinic	clinic	PROPN
fnp-4366	594	162	,	,	PUNCT
fnp-4366	594	163	cleveland	cleveland	PROPN
fnp-4366	594	164	,	,	PUNCT
fnp-4366	595	1	oh	oh	NUM
fnp-4366	595	2	44195	44195	NUM
fnp-4366	595	3	,	,	PUNCT
fnp-4366	595	4	united	united	PROPN
fnp-4366	595	5	states	states	PROPN
fnp-4366	595	6	1	1	NUM
fnp-4366	595	7	charles	charles	PROPN
fnp-4366	595	8	shor	shor	PROPN
fnp-4366	595	9	epilepsy	epilepsy	PROPN
fnp-4366	595	10	center	center	NOUN
fnp-4366	595	11	,	,	PUNCT
fnp-4366	595	12	neurological	neurological	ADJ
fnp-4366	595	13	institute	institute	NOUN
fnp-4366	595	14	,	,	PUNCT
fnp-4366	595	15	cleveland	cleveland	PROPN
fnp-4366	595	16	clinic	clinic	PROPN
fnp-4366	595	17	,	,	PUNCT
fnp-4366	595	18	cleveland	cleveland	PROPN
fnp-4366	595	19	,	,	PUNCT
fnp-4366	595	20	united	united	PROPN
fnp-4366	595	21	states	states	PROPN
fnp-4366	595	22	1	1	NUM
fnp-4366	595	23	stanley	stanley	PROPN
fnp-4366	595	24	center	center	PROPN
fnp-4366	595	25	for	for	ADP
fnp-4366	595	26	psychiatric	psychiatric	ADJ
fnp-4366	595	27	research	research	NOUN
fnp-4366	595	28	,	,	PUNCT
fnp-4366	595	29	broad	broad	PROPN
fnp-4366	595	30	institute	institute	PROPN
fnp-4366	595	31	of	of	ADP
fnp-4366	595	32	harvard	harvard	PROPN
fnp-4366	595	33	and	and	CCONJ
fnp-4366	595	34	m.i.t	m.i.t	PROPN
fnp-4366	595	35	,	,	PUNCT
fnp-4366	595	36	cambridge	cambridge	PROPN
fnp-4366	595	37	,	,	PUNCT
fnp-4366	595	38	ma	ma	PROPN
fnp-4366	595	39	02142	02142	NUM
fnp-4366	595	40	,	,	PUNCT
fnp-4366	595	41	united	united	PROPN
fnp-4366	595	42	states	states	PROPN
fnp-4366	595	43	1	1	NUM
fnp-4366	595	44	cologne	cologne	NOUN
fnp-4366	595	45	center	center	NOUN
fnp-4366	595	46	for	for	ADP
fnp-4366	595	47	genomics	genomics	NOUN
fnp-4366	595	48	(	(	PUNCT
fnp-4366	595	49	ccg	ccg	NOUN
fnp-4366	595	50	)	)	PUNCT
fnp-4366	595	51	,	,	PUNCT
fnp-4366	595	52	medical	medical	ADJ
fnp-4366	595	53	faculty	faculty	NOUN
fnp-4366	595	54	of	of	ADP
fnp-4366	595	55	the	the	DET
fnp-4366	595	56	university	university	NOUN
fnp-4366	595	57	of	of	ADP
fnp-4366	595	58	cologne	cologne	NOUN
fnp-4366	595	59	,	,	PUNCT
fnp-4366	595	60	university	university	NOUN
fnp-4366	595	61	hospital	hospital	NOUN
fnp-4366	595	62	of	of	ADP
fnp-4366	595	63	cologne	cologne	NOUN
fnp-4366	595	64	,	,	PUNCT
fnp-4366	595	65	50931	50931	NUM
fnp-4366	595	66	cologne	cologne	NOUN
fnp-4366	595	67	,	,	PUNCT
fnp-4366	595	68	germany	germany	PROPN
fnp-4366	595	69	1	1	NUM
fnp-4366	595	70	center	center	NOUN
fnp-4366	595	71	for	for	ADP
fnp-4366	595	72	pediatric	pediatric	ADJ
fnp-4366	595	73	neurology	neurology	NOUN
fnp-4366	595	74	,	,	PUNCT
fnp-4366	595	75	neurorehabilitation	neurorehabilitation	NOUN
fnp-4366	595	76	,	,	PUNCT
fnp-4366	595	77	and	and	CCONJ
fnp-4366	595	78	epileptology	epileptology	NOUN
fnp-4366	595	79	,	,	PUNCT
fnp-4366	595	80	schoen	schoen	NOUN
fnp-4366	595	81	-	-	NOUN
fnp-4366	595	82	clinic	clinic	ADJ
fnp-4366	595	83	,	,	PUNCT
fnp-4366	595	84	vogtareuth	vogtareuth	PROPN
fnp-4366	595	85	,	,	PUNCT
fnp-4366	595	86	germany	germany	PROPN
fnp-4366	595	87	1	1	NUM
fnp-4366	595	88	department	department	PROPN
fnp-4366	595	89	of	of	ADP
fnp-4366	595	90	epileptology	epileptology	NOUN
fnp-4366	595	91	(	(	PUNCT
fnp-4366	595	92	krankenhaus	krankenhaus	PROPN
fnp-4366	595	93	mara	mara	PROPN
fnp-4366	595	94	)	)	PUNCT
fnp-4366	595	95	,	,	PUNCT
fnp-4366	595	96	medical	medical	ADJ
fnp-4366	595	97	school	school	NOUN
fnp-4366	595	98	,	,	PUNCT
fnp-4366	595	99	bielefeld	bielefeld	PROPN
fnp-4366	595	100	university	university	PROPN
fnp-4366	595	101	,	,	PUNCT
fnp-4366	595	102	bielefeld	bielefeld	PROPN
fnp-4366	595	103	,	,	PUNCT
fnp-4366	595	104	germany	germany	PROPN
fnp-4366	595	105	1	1	NUM
fnp-4366	595	106	epilepsy	epilepsy	NOUN
fnp-4366	595	107	center	center	NOUN
fnp-4366	595	108	,	,	PUNCT
fnp-4366	595	109	universitätsklinikum	universitätsklinikum	ADJ
fnp-4366	595	110	erlangen	erlangen	PROPN
fnp-4366	595	111	,	,	PUNCT
fnp-4366	595	112	fau	fau	PROPN
fnp-4366	595	113	erlangen	erlangen	PROPN
fnp-4366	595	114	-	-	PUNCT
fnp-4366	595	115	nürnberg	nürnberg	PROPN
fnp-4366	595	116	,	,	PUNCT
fnp-4366	595	117	and	and	CCONJ
fnp-4366	595	118	epicare	epicare	PROPN
fnp-4366	595	119	partner	partner	PROPN
fnp-4366	595	120	,	,	PUNCT
fnp-4366	595	121	erlangen	erlangen	PROPN
fnp-4366	595	122	,	,	PUNCT
fnp-4366	595	123	germany	germany	PROPN
fnp-4366	595	124	1	1	NUM
fnp-4366	595	125	department	department	NOUN
fnp-4366	595	126	of	of	ADP
fnp-4366	595	127	neurosurgery	neurosurgery	NOUN
fnp-4366	595	128	,	,	PUNCT
fnp-4366	595	129	universitätsklinikum	universitätsklinikum	ADJ
fnp-4366	595	130	erlangen	erlangen	PROPN
fnp-4366	595	131	,	,	PUNCT
fnp-4366	595	132	fau	fau	PROPN
fnp-4366	595	133	erlangen	erlangen	PROPN
fnp-4366	595	134	-	-	PUNCT
fnp-4366	595	135	nürnberg	nürnberg	PROPN
fnp-4366	595	136	,	,	PUNCT
fnp-4366	595	137	erlangen	erlangen	PROPN
fnp-4366	595	138	,	,	PUNCT
fnp-4366	595	139	germany	germany	PROPN
fnp-4366	595	140	1	1	NUM
fnp-4366	595	141	department	department	NOUN
fnp-4366	595	142	of	of	ADP
fnp-4366	595	143	neurosurgery	neurosurgery	NOUN
fnp-4366	595	144	,	,	PUNCT
fnp-4366	595	145	medical	medical	ADJ
fnp-4366	595	146	university	university	PROPN
fnp-4366	595	147	of	of	ADP
fnp-4366	595	148	vienna	vienna	PROPN
fnp-4366	595	149	,	,	PUNCT
fnp-4366	595	150	vienna	vienna	PROPN
fnp-4366	595	151	general	general	PROPN
fnp-4366	595	152	hospital	hospital	PROPN
fnp-4366	595	153	,	,	PUNCT
fnp-4366	595	154	vienna	vienna	PROPN
fnp-4366	595	155	,	,	PUNCT
fnp-4366	595	156	austria	austria	PROPN
fnp-4366	595	157	1	1	NUM
fnp-4366	595	158	department	department	NOUN
fnp-4366	595	159	of	of	ADP
fnp-4366	595	160	neuroradiology	neuroradiology	NOUN
fnp-4366	595	161	,	,	PUNCT
fnp-4366	595	162	universitätsklinikum	universitätsklinikum	PROPN
fnp-4366	595	163	erlangen	erlangen	PROPN
fnp-4366	595	164	,	,	PUNCT
fnp-4366	595	165	fau	fau	PROPN
fnp-4366	595	166	erlangen	erlangen	PROPN
fnp-4366	595	167	-	-	PUNCT
fnp-4366	595	168	nürnberg	nürnberg	PROPN
fnp-4366	595	169	,	,	PUNCT
fnp-4366	595	170	erlangen	erlangen	PROPN
fnp-4366	595	171	,	,	PUNCT
fnp-4366	595	172	germany	germany	PROPN
fnp-4366	595	173	1	1	NUM
fnp-4366	595	174	sorbonne	sorbonne	PROPN
fnp-4366	595	175	université	université	PROPN
fnp-4366	595	176	,	,	PUNCT
fnp-4366	595	177	institut	institut	PROPN
fnp-4366	595	178	du	du	PROPN
fnp-4366	595	179	cerveau	cerveau	PROPN
fnp-4366	595	180	paris	paris	PROPN
fnp-4366	595	181	brain	brain	PROPN
fnp-4366	595	182	institute	institute	PROPN
fnp-4366	595	183	icm	icm	PROPN
fnp-4366	595	184	,	,	PUNCT
fnp-4366	595	185	inserm	inserm	NOUN
fnp-4366	595	186	,	,	PUNCT
fnp-4366	595	187	cnrs	cnrs	NOUN
fnp-4366	595	188	,	,	PUNCT
fnp-4366	595	189	aphp	aphp	ADJ
fnp-4366	595	190	,	,	PUNCT
fnp-4366	595	191	hôpital	hôpital	PROPN
fnp-4366	595	192	de	de	PROPN
fnp-4366	595	193	la	la	PROPN
fnp-4366	595	194	pitié	pitié	PROPN
fnp-4366	595	195	salpêtrière	salpêtrière	PROPN
fnp-4366	595	196	,	,	PUNCT
fnp-4366	595	197	paris	paris	PROPN
fnp-4366	595	198	,	,	PUNCT
fnp-4366	595	199	france	france	PROPN
fnp-4366	595	200	background	background	NOUN
fnp-4366	595	201	:	:	PUNCT
fnp-4366	595	202	focal	focal	ADJ
fnp-4366	595	203	cortical	cortical	ADJ
fnp-4366	595	204	dysplasia	dysplasia	NOUN
fnp-4366	595	205	type	type	NOUN
fnp-4366	595	206	2	2	NUM
fnp-4366	595	207	(	(	PUNCT
fnp-4366	595	208	fcd2	fcd2	PROPN
fnp-4366	595	209	)	)	PUNCT
fnp-4366	595	210	is	be	AUX
fnp-4366	595	211	the	the	DET
fnp-4366	595	212	single	single	ADJ
fnp-4366	595	213	most	most	ADV
fnp-4366	595	214	common	common	ADJ
fnp-4366	595	215	cause	cause	NOUN
fnp-4366	595	216	of	of	ADP
fnp-4366	595	217	drug	drug	NOUN
fnp-4366	595	218	-	-	PUNCT
fnp-4366	595	219	resistant	resistant	ADJ
fnp-4366	595	220	focal	focal	ADJ
fnp-4366	595	221	epilepsy	epilepsy	NOUN
fnp-4366	595	222	in	in	ADP
fnp-4366	595	223	children	child	NOUN
fnp-4366	595	224	.	.	PUNCT
fnp-4366	596	1	despite	despite	SCONJ
fnp-4366	596	2	continuous	continuous	ADJ
fnp-4366	596	3	progress	progress	NOUN
fnp-4366	596	4	in	in	ADP
fnp-4366	596	5	diagnostic	diagnostic	ADJ
fnp-4366	596	6	methods	method	NOUN
fnp-4366	596	7	,	,	PUNCT
fnp-4366	596	8	however	however	ADV
fnp-4366	596	9	,	,	PUNCT
fnp-4366	596	10	the	the	DET
fnp-4366	596	11	recognition	recognition	NOUN
fnp-4366	596	12	and	and	CCONJ
fnp-4366	596	13	treatment	treatment	NOUN
fnp-4366	596	14	of	of	ADP
fnp-4366	596	15	fcd2	fcd2	PROPN
fnp-4366	596	16	subtypes	subtype	NOUN
fnp-4366	596	17	remain	remain	VERB
fnp-4366	596	18	a	a	DET
fnp-4366	596	19	challenging	challenging	ADJ
fnp-4366	596	20	issue	issue	NOUN
fnp-4366	596	21	in	in	ADP
fnp-4366	596	22	clinical	clinical	ADJ
fnp-4366	596	23	practice	practice	NOUN
fnp-4366	596	24	.	.	PUNCT
fnp-4366	597	1	herein	herein	NOUN
fnp-4366	597	2	,	,	PUNCT
fnp-4366	597	3	we	we	PRON
fnp-4366	597	4	performed	perform	VERB
fnp-4366	597	5	a	a	DET
fnp-4366	597	6	deep	deep	ADJ
fnp-4366	597	7	genotype	genotype	NOUN
fnp-4366	597	8	-	-	PUNCT
fnp-4366	597	9	phenotype	phenotype	NOUN
fnp-4366	597	10	analysis	analysis	NOUN
fnp-4366	597	11	to	to	PART
fnp-4366	597	12	further	far	ADV
fnp-4366	597	13	elucidate	elucidate	VERB
fnp-4366	597	14	the	the	DET
fnp-4366	597	15	clinical	clinical	ADJ
fnp-4366	597	16	-	-	PUNCT
fnp-4366	597	17	pathological	pathological	ADJ
fnp-4366	597	18	and	and	CCONJ
fnp-4366	597	19	genetic	genetic	ADJ
fnp-4366	597	20	presentation	presentation	NOUN
fnp-4366	597	21	of	of	ADP
fnp-4366	597	22	fcd2	fcd2	PROPN
fnp-4366	597	23	.	.	PUNCT
fnp-4366	598	1	methods	method	NOUN
fnp-4366	598	2	:	:	PUNCT
fnp-4366	598	3	patients	patient	NOUN
fnp-4366	598	4	with	with	ADP
fnp-4366	598	5	focal	focal	ADJ
fnp-4366	598	6	epilepsy	epilepsy	NOUN
fnp-4366	598	7	submitted	submit	VERB
fnp-4366	598	8	to	to	ADP
fnp-4366	598	9	neurosurgical	neurosurgical	ADJ
fnp-4366	598	10	treatment	treatment	NOUN
fnp-4366	598	11	,	,	PUNCT
fnp-4366	598	12	histopathological	histopathological	ADJ
fnp-4366	598	13	confirmed	confirm	VERB
fnp-4366	598	14	diagnosis	diagnosis	NOUN
fnp-4366	598	15	of	of	ADP
fnp-4366	598	16	fcd	fcd	ADJ
fnp-4366	598	17	ilae	ilae	NOUN
fnp-4366	598	18	type	type	NOUN
fnp-4366	598	19	2	2	NUM
fnp-4366	598	20	and	and	CCONJ
fnp-4366	598	21	positive	positive	ADJ
fnp-4366	598	22	genetic	genetic	ADJ
fnp-4366	598	23	testing	testing	NOUN
fnp-4366	598	24	were	be	AUX
fnp-4366	598	25	retrieved	retrieve	VERB
fnp-4366	598	26	from	from	ADP
fnp-4366	598	27	the	the	DET
fnp-4366	598	28	european	european	ADJ
fnp-4366	598	29	epilepsy	epilepsy	PROPN
fnp-4366	598	30	brain	brain	NOUN
fnp-4366	598	31	bank	bank	PROPN
fnp-4366	598	32	.	.	PUNCT
fnp-4366	599	1	clinical	clinical	ADJ
fnp-4366	599	2	data	datum	NOUN
fnp-4366	599	3	were	be	AUX
fnp-4366	599	4	available	available	ADJ
fnp-4366	599	5	from	from	ADP
fnp-4366	599	6	the	the	DET
fnp-4366	599	7	contributing	contribute	VERB
fnp-4366	599	8	epilepsy	epilepsy	NOUN
fnp-4366	599	9	centers	center	NOUN
fnp-4366	599	10	.	.	PUNCT
fnp-4366	600	1	deep	deep	ADJ
fnp-4366	600	2	whole	whole	ADJ
fnp-4366	600	3	-	-	PUNCT
fnp-4366	600	4	exome	exome	NOUN
fnp-4366	600	5	sequencing	sequence	VERB
fnp-4366	600	6	with	with	ADP
fnp-4366	600	7	a	a	DET
fnp-4366	600	8	coverage	coverage	NOUN
fnp-4366	600	9	of	of	ADP
fnp-4366	600	10	>	>	X
fnp-4366	600	11	350x	350x	NUM
fnp-4366	600	12	or	or	CCONJ
fnp-4366	600	13	mtor	mtor	NOUN
fnp-4366	600	14	gene	gene	NOUN
fnp-4366	600	15	panel	panel	NOUN
fnp-4366	600	16	sequencing	sequence	VERB
fnp-4366	600	17	with	with	ADP
fnp-4366	600	18	a	a	DET
fnp-4366	600	19	coverage	coverage	NOUN
fnp-4366	600	20	of	of	ADP
fnp-4366	600	21	>	>	X
fnp-4366	600	22	1000x	1000x	NUM
fnp-4366	600	23	were	be	AUX
fnp-4366	600	24	obtained	obtain	VERB
fnp-4366	600	25	from	from	ADP
fnp-4366	600	26	fresh	fresh	ADJ
fnp-4366	600	27	frozen	frozen	ADJ
fnp-4366	600	28	tissue	tissue	NOUN
fnp-4366	600	29	samples	sample	NOUN
fnp-4366	600	30	.	.	PUNCT
fnp-4366	601	1	histopathological	histopathological	ADJ
fnp-4366	601	2	analyses	analysis	NOUN
fnp-4366	601	3	were	be	AUX
fnp-4366	601	4	performed	perform	VERB
fnp-4366	601	5	from	from	ADP
fnp-4366	601	6	formalin	formalin	NOUN
fnp-4366	601	7	-	-	PUNCT
fnp-4366	601	8	fixed	fix	VERB
fnp-4366	601	9	,	,	PUNCT
fnp-4366	601	10	paraffin	paraffin	NOUN
fnp-4366	601	11	embedded	embed	VERB
fnp-4366	601	12	tissue	tissue	NOUN
fnp-4366	601	13	samples	sample	NOUN
fnp-4366	601	14	using	use	VERB
fnp-4366	601	15	he	he	PRON
fnp-4366	601	16	and	and	CCONJ
fnp-4366	601	17	immunohistochemistry	immunohistochemistry	VERB
fnp-4366	601	18	for	for	ADP
fnp-4366	601	19	nf	nf	NOUN
fnp-4366	601	20	-	-	PUNCT
fnp-4366	601	21	smi32	smi32	ADJ
fnp-4366	601	22	,	,	PUNCT
fnp-4366	601	23	neun	neun	NOUN
fnp-4366	601	24	,	,	PUNCT
fnp-4366	601	25	ps6	ps6	ADJ
fnp-4366	601	26	,	,	PUNCT
fnp-4366	601	27	p62	p62	NOUN
fnp-4366	601	28	,	,	PUNCT
fnp-4366	601	29	and	and	CCONJ
fnp-4366	601	30	vimentin	vimentin	NOUN
fnp-4366	601	31	.	.	PUNCT
fnp-4366	602	1	all	all	DET
fnp-4366	602	2	slides	slide	NOUN
fnp-4366	602	3	were	be	AUX
fnp-4366	602	4	digitalised	digitalise	VERB
fnp-4366	602	5	and	and	CCONJ
fnp-4366	602	6	further	far	ADV
fnp-4366	602	7	analysed	analyse	VERB
fnp-4366	602	8	with	with	ADP
fnp-4366	602	9	qupath	qupath	NOUN
fnp-4366	602	10	v.0.3.0	v.0.3.0	NOUN
fnp-4366	602	11	.	.	PUNCT
fnp-4366	603	1	results	result	NOUN
fnp-4366	603	2	:	:	PUNCT
fnp-4366	603	3	seventeen	seventeen	NUM
fnp-4366	603	4	patients	patient	NOUN
fnp-4366	603	5	were	be	AUX
fnp-4366	603	6	identified	identify	VERB
fnp-4366	603	7	by	by	ADP
fnp-4366	603	8	carrying	carry	VERB
fnp-4366	603	9	pathogenetic	pathogenetic	ADJ
fnp-4366	603	10	variants	variant	NOUN
fnp-4366	603	11	in	in	ADP
fnp-4366	603	12	genes	gene	NOUN
fnp-4366	603	13	directly	directly	ADV
fnp-4366	603	14	associated	associate	VERB
fnp-4366	603	15	with	with	ADP
fnp-4366	603	16	the	the	DET
fnp-4366	603	17	mtor	mtor	PROPN
fnp-4366	603	18	pathway	pathway	NOUN
fnp-4366	603	19	,	,	PUNCT
fnp-4366	603	20	i.e.	i.e.	X
fnp-4366	603	21	,	,	PUNCT
fnp-4366	603	22	loss	loss	NOUN
fnp-4366	603	23	-	-	PUNCT
fnp-4366	603	24	of	of	ADP
fnp-4366	603	25	-	-	PUNCT
fnp-4366	603	26	function	function	NOUN
fnp-4366	603	27	in	in	ADP
fnp-4366	603	28	the	the	DET
fnp-4366	603	29	gator1	gator1	NOUN
fnp-4366	603	30	complex	complex	NOUN
fnp-4366	603	31	(	(	PUNCT
fnp-4366	603	32	depdc5	depdc5	PROPN
fnp-4366	603	33	,	,	PUNCT
fnp-4366	603	34	n=7	n=7	PROPN
fnp-4366	603	35	and	and	CCONJ
fnp-4366	603	36	nprl3	nprl3	PROPN
fnp-4366	603	37	,	,	PUNCT
fnp-4366	603	38	n=3	n=3	NOUN
fnp-4366	603	39	)	)	PUNCT
fnp-4366	603	40	,	,	PUNCT
fnp-4366	603	41	or	or	CCONJ
fnp-4366	603	42	gain	gain	VERB
fnp-4366	603	43	-	-	PUNCT
fnp-4366	603	44	of	of	ADP
fnp-4366	603	45	-	-	PUNCT
fnp-4366	603	46	function	function	NOUN
fnp-4366	603	47	in	in	ADP
fnp-4366	603	48	the	the	DET
fnp-4366	603	49	mtorc1	mtorc1	NOUN
fnp-4366	603	50	signalling	signal	VERB
fnp-4366	603	51	pathway	pathway	NOUN
fnp-4366	604	1	[	[	X
fnp-4366	604	2	mtor	mtor	NOUN
fnp-4366	604	3	,	,	PUNCT
fnp-4366	604	4	n=7	n=7	PROPN
fnp-4366	604	5	]	]	PUNCT
fnp-4366	604	6	.	.	PUNCT
fnp-4366	605	1	all	all	DET
fnp-4366	605	2	patients	patient	NOUN
fnp-4366	605	3	were	be	AUX
fnp-4366	605	4	seizure	seizure	VERB
fnp-4366	605	5	-	-	PUNCT
fnp-4366	605	6	free	free	ADJ
fnp-4366	605	7	after	after	ADP
fnp-4366	605	8	surgery	surgery	NOUN
fnp-4366	605	9	with	with	ADP
fnp-4366	605	10	the	the	DET
fnp-4366	605	11	exception	exception	NOUN
fnp-4366	605	12	of	of	ADP
fnp-4366	605	13	four	four	NUM
fnp-4366	605	14	patients	patient	NOUN
fnp-4366	605	15	carrying	carry	VERB
fnp-4366	605	16	a	a	DET
fnp-4366	605	17	depdc5	depdc5	NOUN
fnp-4366	605	18	mutation	mutation	NOUN
fnp-4366	605	19	.	.	PUNCT
fnp-4366	606	1	histopathological	histopathological	ADJ
fnp-4366	606	2	analysis	analysis	NOUN
fnp-4366	606	3	revealed	reveal	VERB
fnp-4366	606	4	a	a	DET
fnp-4366	606	5	fcd2a	fcd2a	NOUN
fnp-4366	606	6	subtype	subtype	NOUN
fnp-4366	606	7	in	in	ADP
fnp-4366	606	8	all	all	DET
fnp-4366	606	9	cases	case	NOUN
fnp-4366	606	10	with	with	ADP
fnp-4366	606	11	gator1	gator1	NOUN
fnp-4366	606	12	alteration	alteration	NOUN
fnp-4366	606	13	,	,	PUNCT
fnp-4366	606	14	i.e.	i.e.	X
fnp-4366	606	15	,	,	PUNCT
fnp-4366	606	16	no	no	DET
fnp-4366	606	17	balloon	balloon	NOUN
fnp-4366	606	18	cells	cell	NOUN
fnp-4366	606	19	.	.	PUNCT
fnp-4366	607	1	in	in	ADP
fnp-4366	607	2	contrast	contrast	NOUN
fnp-4366	607	3	,	,	PUNCT
fnp-4366	607	4	the	the	DET
fnp-4366	607	5	fcd2b	fcd2b	PROPN
fnp-4366	607	6	subtype	subtype	NOUN
fnp-4366	607	7	was	be	AUX
fnp-4366	607	8	predominant	predominant	ADJ
fnp-4366	607	9	in	in	ADP
fnp-4366	607	10	cases	case	NOUN
fnp-4366	607	11	with	with	ADP
fnp-4366	607	12	gene	gene	NOUN
fnp-4366	607	13	variants	variant	NOUN
fnp-4366	607	14	affecting	affect	VERB
fnp-4366	607	15	the	the	DET
fnp-4366	607	16	mtorc1	mtorc1	NOUN
fnp-4366	607	17	signalling	signal	VERB
fnp-4366	607	18	complex	complex	NOUN
fnp-4366	607	19	.	.	PUNCT
fnp-4366	608	1	specimens	specimen	NOUN
fnp-4366	608	2	carrying	carry	VERB
fnp-4366	608	3	mtor	mtor	NOUN
fnp-4366	608	4	variants	variant	NOUN
fnp-4366	608	5	also	also	ADV
fnp-4366	608	6	had	have	VERB
fnp-4366	608	7	significantly	significantly	ADV
fnp-4366	608	8	larger	large	ADJ
fnp-4366	608	9	dysmorphic	dysmorphic	ADJ
fnp-4366	608	10	neurons	neuron	NOUN
fnp-4366	608	11	than	than	ADP
fnp-4366	608	12	gator1	gator1	NOUN
fnp-4366	608	13	variants	variant	NOUN
fnp-4366	608	14	[	[	X
fnp-4366	608	15	p=0.005	p=0.005	X
fnp-4366	608	16	]	]	PUNCT
fnp-4366	608	17	.	.	PUNCT
fnp-4366	609	1	in	in	ADP
fnp-4366	609	2	addition	addition	NOUN
fnp-4366	609	3	,	,	PUNCT
fnp-4366	609	4	five	five	NUM
fnp-4366	609	5	cases	case	NOUN
fnp-4366	609	6	defined	define	VERB
fnp-4366	609	7	by	by	ADP
fnp-4366	609	8	gator1	gator1	NOUN
fnp-4366	609	9	variants	variant	NOUN
fnp-4366	609	10	showed	show	VERB
fnp-4366	609	11	a	a	DET
fnp-4366	609	12	unique	unique	ADJ
fnp-4366	609	13	and	and	CCONJ
fnp-4366	609	14	predominantly	predominantly	ADV
fnp-4366	609	15	vacuolizing	vacuolize	VERB
fnp-4366	609	16	phenotype	phenotype	NOUN
fnp-4366	609	17	(	(	PUNCT
fnp-4366	609	18	figure	figure	NOUN
fnp-4366	609	19	1c	1c	NOUN
fnp-4366	609	20	)	)	PUNCT
fnp-4366	609	21	.	.	PUNCT
fnp-4366	610	1	all	all	DET
fnp-4366	610	2	cases	case	NOUN
fnp-4366	610	3	with	with	ADP
fnp-4366	610	4	gator1	gator1	NOUN
fnp-4366	610	5	alterations	alteration	NOUN
fnp-4366	610	6	were	be	AUX
fnp-4366	610	7	located	locate	VERB
fnp-4366	610	8	in	in	ADP
fnp-4366	610	9	the	the	DET
fnp-4366	610	10	frontal	frontal	ADJ
fnp-4366	610	11	lobe	lobe	NOUN
fnp-4366	610	12	and	and	CCONJ
fnp-4366	610	13	the	the	DET
fnp-4366	610	14	majority	majority	NOUN
fnp-4366	610	15	was	be	AUX
fnp-4366	610	16	confined	confine	VERB
fnp-4366	610	17	to	to	ADP
fnp-4366	610	18	the	the	DET
fnp-4366	610	19	cortical	cortical	ADJ
fnp-4366	610	20	ribbon	ribbon	NOUN
fnp-4366	610	21	not	not	PART
fnp-4366	610	22	affecting	affect	VERB
fnp-4366	610	23	the	the	DET
fnp-4366	610	24	white	white	ADJ
fnp-4366	610	25	matter	matter	NOUN
fnp-4366	610	26	(	(	PUNCT
fnp-4366	610	27	figure	figure	NOUN
fnp-4366	610	28	1a	1a	NOUN
fnp-4366	610	29	)	)	PUNCT
fnp-4366	610	30	.	.	PUNCT
fnp-4366	611	1	this	this	DET
fnp-4366	611	2	pattern	pattern	NOUN
fnp-4366	611	3	was	be	AUX
fnp-4366	611	4	reflected	reflect	VERB
fnp-4366	611	5	by	by	ADP
fnp-4366	611	6	subtle	subtle	ADJ
fnp-4366	611	7	or	or	CCONJ
fnp-4366	611	8	negative	negative	ADJ
fnp-4366	611	9	mri	mri	NOUN
fnp-4366	611	10	findings	finding	NOUN
fnp-4366	611	11	in	in	ADP
fnp-4366	611	12	9/10	9/10	NUM
fnp-4366	611	13	patients	patient	NOUN
fnp-4366	611	14	with	with	ADP
fnp-4366	611	15	gator1	gator1	NOUN
fnp-4366	611	16	variants	variant	NOUN
fnp-4366	611	17	.	.	PUNCT
fnp-4366	612	1	discussion	discussion	NOUN
fnp-4366	612	2	/	/	SYM
fnp-4366	612	3	conclusion	conclusion	NOUN
fnp-4366	612	4	:	:	PUNCT
fnp-4366	612	5	we	we	PRON
fnp-4366	612	6	describe	describe	VERB
fnp-4366	612	7	a	a	DET
fnp-4366	612	8	yet	yet	ADV
fnp-4366	612	9	unrecognized	unrecognized	ADJ
fnp-4366	612	10	genotype	genotype	NOUN
fnp-4366	612	11	-	-	PUNCT
fnp-4366	612	12	phenotype	phenotype	NOUN
fnp-4366	612	13	correlation	correlation	NOUN
fnp-4366	612	14	of	of	ADP
fnp-4366	612	15	gator1	gator1	NOUN
fnp-4366	612	16	variants	variant	NOUN
fnp-4366	612	17	with	with	ADP
fnp-4366	612	18	fcd2a	fcd2a	PROPN
fnp-4366	612	19	in	in	ADP
fnp-4366	612	20	the	the	DET
fnp-4366	612	21	frontal	frontal	ADJ
fnp-4366	612	22	lobe	lobe	NOUN
fnp-4366	612	23	.	.	PUNCT
fnp-4366	613	1	these	these	DET
fnp-4366	613	2	lesions	lesion	NOUN
fnp-4366	613	3	were	be	AUX
fnp-4366	613	4	histopathological	histopathological	ADJ
fnp-4366	613	5	further	far	ADV
fnp-4366	613	6	characterized	characterize	VERB
fnp-4366	613	7	by	by	ADP
fnp-4366	613	8	abnormally	abnormally	ADV
fnp-4366	613	9	vacuolizing	vacuolize	VERB
fnp-4366	613	10	cells	cell	NOUN
fnp-4366	613	11	suggestive	suggestive	ADJ
fnp-4366	613	12	of	of	ADP
fnp-4366	613	13	an	an	DET
fnp-4366	613	14	autophagy	autophagy	ADJ
fnp-4366	613	15	altered	alter	VERB
fnp-4366	613	16	phenotype	phenotype	NOUN
fnp-4366	613	17	.	.	PUNCT
fnp-4366	614	1	from	from	ADP
fnp-4366	614	2	recently	recently	ADV
fnp-4366	614	3	published	publish	VERB
fnp-4366	614	4	evidence	evidence	NOUN
fnp-4366	614	5	,	,	PUNCT
fnp-4366	614	6	we	we	PRON
fnp-4366	614	7	also	also	ADV
fnp-4366	614	8	hypothesize	hypothesize	VERB
fnp-4366	614	9	that	that	SCONJ
fnp-4366	614	10	this	this	DET
fnp-4366	614	11	subtype	subtype	NOUN
fnp-4366	614	12	will	will	AUX
fnp-4366	614	13	carry	carry	VERB
fnp-4366	614	14	a	a	DET
fnp-4366	614	15	second	second	ADJ
fnp-4366	614	16	hit	hit	VERB
fnp-4366	614	17	brain	brain	NOUN
fnp-4366	614	18	somatic	somatic	ADJ
fnp-4366	614	19	variant	variant	NOUN
fnp-4366	614	20	in	in	ADP
fnp-4366	614	21	the	the	DET
fnp-4366	614	22	depdc5	depdc5	NOUN
fnp-4366	614	23	gene	gene	NOUN
fnp-4366	614	24	,	,	PUNCT
fnp-4366	614	25	which	which	PRON
fnp-4366	614	26	was	be	AUX
fnp-4366	614	27	,	,	PUNCT
fnp-4366	614	28	however	however	ADV
fnp-4366	614	29	,	,	PUNCT
fnp-4366	614	30	difficult	difficult	ADJ
fnp-4366	614	31	to	to	PART
fnp-4366	614	32	identify	identify	VERB
fnp-4366	614	33	with	with	ADP
fnp-4366	614	34	techniques	technique	NOUN
fnp-4366	614	35	applied	apply	VERB
fnp-4366	614	36	in	in	ADP
fnp-4366	614	37	our	our	PRON
fnp-4366	614	38	current	current	ADJ
fnp-4366	614	39	study	study	NOUN
fnp-4366	614	40	.	.	PUNCT
fnp-4366	615	1	in	in	ADP
fnp-4366	615	2	contrast	contrast	NOUN
fnp-4366	615	3	,	,	PUNCT
fnp-4366	615	4	patients	patient	NOUN
fnp-4366	615	5	with	with	ADP
fnp-4366	615	6	fcd2b	fcd2b	PROPN
fnp-4366	615	7	and	and	CCONJ
fnp-4366	615	8	brain	brain	NOUN
fnp-4366	615	9	somatic	somatic	ADJ
fnp-4366	615	10	mtor	mtor	NOUN
fnp-4366	615	11	variants	variant	NOUN
fnp-4366	615	12	showed	show	VERB
fnp-4366	615	13	larger	large	ADJ
fnp-4366	615	14	lesions	lesion	NOUN
fnp-4366	615	15	on	on	ADP
fnp-4366	615	16	mri	mri	NOUN
fnp-4366	615	17	including	include	VERB
fnp-4366	615	18	the	the	DET
fnp-4366	615	19	white	white	ADJ
fnp-4366	615	20	matter	matter	NOUN
fnp-4366	615	21	,	,	PUNCT
fnp-4366	615	22	suggesting	suggest	VERB
fnp-4366	615	23	compromised	compromise	VERB
fnp-4366	615	24	neural	neural	ADJ
fnp-4366	615	25	migration	migration	NOUN
fnp-4366	615	26	(	(	PUNCT
fnp-4366	615	27	figure	figure	NOUN
fnp-4366	615	28	1b	1b	NUM
fnp-4366	615	29	)	)	PUNCT
fnp-4366	615	30	.	.	PUNCT
fnp-4366	616	1	these	these	DET
fnp-4366	616	2	data	datum	NOUN
fnp-4366	616	3	may	may	AUX
fnp-4366	616	4	help	help	VERB
fnp-4366	616	5	to	to	PART
fnp-4366	616	6	better	well	ADV
fnp-4366	616	7	understand	understand	VERB
fnp-4366	616	8	difficult	difficult	ADJ
fnp-4366	616	9	-	-	PUNCT
fnp-4366	616	10	to	to	ADP
fnp-4366	616	11	-	-	PUNCT
fnp-4366	616	12	diagnose	diagnose	VERB
fnp-4366	616	13	and	and	CCONJ
fnp-4366	616	14	treat	treat	VERB
fnp-4366	616	15	fcd	fcd	ADJ
fnp-4366	616	16	subtypes	subtype	NOUN
fnp-4366	616	17	,	,	PUNCT
fnp-4366	616	18	i.e.	i.e.	X
fnp-4366	616	19	,	,	PUNCT
fnp-4366	616	20	ilae	ilae	NOUN
fnp-4366	616	21	type	type	NOUN
fnp-4366	616	22	2a	2a	NUM
fnp-4366	616	23	and	and	CCONJ
fnp-4366	616	24	2b	2b	NOUN
fnp-4366	616	25	.	.	PUNCT
fnp-4366	617	1	figure	figure	NOUN
fnp-4366	617	2	1	1	NUM
fnp-4366	617	3	:	:	PUNCT
fnp-4366	617	4	genotype	genotype	NOUN
fnp-4366	617	5	-	-	PUNCT
fnp-4366	617	6	phenotype	phenotype	NOUN
fnp-4366	617	7	analysis	analysis	NOUN
fnp-4366	617	8	of	of	ADP
fnp-4366	617	9	fcd	fcd	ADJ
fnp-4366	617	10	ilae	ilae	NOUN
fnp-4366	617	11	type	type	NOUN
fnp-4366	617	12	2	2	NUM
fnp-4366	617	13	a	a	DET
fnp-4366	617	14	:	:	PUNCT
fnp-4366	617	15	42	42	NUM
fnp-4366	617	16	-	-	PUNCT
fnp-4366	617	17	year	year	NOUN
fnp-4366	617	18	-	-	PUNCT
fnp-4366	617	19	old	old	ADJ
fnp-4366	617	20	male	male	ADJ
fnp-4366	617	21	patient	patient	NOUN
fnp-4366	617	22	with	with	ADP
fnp-4366	617	23	frontal	frontal	ADJ
fnp-4366	617	24	lobe	lobe	NOUN
fnp-4366	617	25	epilepsy	epilepsy	NOUN
fnp-4366	617	26	since	since	SCONJ
fnp-4366	617	27	age	age	NOUN
fnp-4366	617	28	5	5	NUM
fnp-4366	617	29	years	year	NOUN
fnp-4366	617	30	,	,	PUNCT
fnp-4366	617	31	histopathological	histopathological	ADJ
fnp-4366	617	32	confirmed	confirm	VERB
fnp-4366	617	33	fcd2a	fcd2a	PROPN
fnp-4366	617	34	and	and	CCONJ
fnp-4366	617	35	a	a	DET
fnp-4366	617	36	pathogenic	pathogenic	ADJ
fnp-4366	617	37	depdc5	depdc5	NOUN
fnp-4366	617	38	mosaicism	mosaicism	NOUN
fnp-4366	617	39	.	.	PUNCT
fnp-4366	618	1	the	the	DET
fnp-4366	618	2	arrow	arrow	NOUN
fnp-4366	618	3	points	point	NOUN
fnp-4366	618	4	to	to	ADP
fnp-4366	618	5	the	the	DET
fnp-4366	618	6	sharp	sharp	ADJ
fnp-4366	618	7	border	border	NOUN
fnp-4366	618	8	between	between	ADP
fnp-4366	618	9	the	the	DET
fnp-4366	618	10	cortical	cortical	ADJ
fnp-4366	618	11	fcd	fcd	NOUN
fnp-4366	618	12	and	and	CCONJ
fnp-4366	618	13	the	the	DET
fnp-4366	618	14	normal	normal	ADJ
fnp-4366	618	15	appearing	appearing	ADJ
fnp-4366	618	16	white	white	ADJ
fnp-4366	618	17	matter	matter	NOUN
fnp-4366	618	18	(	(	PUNCT
fnp-4366	618	19	wm	wm	PROPN
fnp-4366	618	20	)	)	PUNCT
fnp-4366	618	21	.	.	PUNCT
fnp-4366	619	1	ncx	ncx	ADP
fnp-4366	619	2	normal	normal	ADJ
fnp-4366	619	3	6	6	NUM
fnp-4366	619	4	-	-	PUNCT
fnp-4366	619	5	layered	layered	ADJ
fnp-4366	619	6	neocortex	neocortex	NOUN
fnp-4366	619	7	.	.	PUNCT
fnp-4366	620	1	neurofilament	neurofilament	PROPN
fnp-4366	620	2	smi32	smi32	PROPN
fnp-4366	620	3	immunohistochemistry	immunohistochemistry	PROPN
fnp-4366	620	4	.	.	PUNCT
fnp-4366	621	1	scale	scale	NOUN
fnp-4366	621	2	bar	bar	NOUN
fnp-4366	621	3	=	=	PUNCT
fnp-4366	621	4	2.5	2.5	NUM
fnp-4366	621	5	mm	mm	NOUN
fnp-4366	621	6	(	(	PUNCT
fnp-4366	621	7	applies	apply	VERB
fnp-4366	621	8	also	also	ADV
fnp-4366	621	9	to	to	ADP
fnp-4366	621	10	b	b	X
fnp-4366	621	11	)	)	PUNCT
fnp-4366	621	12	.	.	PUNCT
fnp-4366	622	1	higher	high	ADJ
fnp-4366	622	2	magnification	magnification	NOUN
fnp-4366	622	3	in	in	ADP
fnp-4366	622	4	c	c	PROPN
fnp-4366	622	5	reveals	reveal	VERB
fnp-4366	622	6	dysmorphic	dysmorphic	ADJ
fnp-4366	622	7	neurons	neuron	NOUN
fnp-4366	622	8	with	with	ADP
fnp-4366	622	9	a	a	DET
fnp-4366	622	10	vacuolizing	vacuolize	VERB
fnp-4366	622	11	predominant	predominant	ADJ
fnp-4366	622	12	phenotype	phenotype	NOUN
fnp-4366	622	13	(	(	PUNCT
fnp-4366	622	14	red	red	ADJ
fnp-4366	622	15	arrow	arrow	NOUN
fnp-4366	622	16	)	)	PUNCT
fnp-4366	622	17	suggesting	suggest	VERB
fnp-4366	622	18	an	an	DET
fnp-4366	622	19	autophagy	autophagy	ADJ
fnp-4366	622	20	altered	alter	VERB
fnp-4366	622	21	phenotype	phenotype	NOUN
fnp-4366	622	22	.	.	PUNCT
fnp-4366	623	1	scale	scale	NOUN
fnp-4366	623	2	bar	bar	NOUN
fnp-4366	623	3	=	=	NOUN
fnp-4366	623	4	100	100	NUM
fnp-4366	623	5	µm	µm	NUM
fnp-4366	623	6	(	(	PUNCT
fnp-4366	623	7	applies	apply	VERB
fnp-4366	623	8	also	also	ADV
fnp-4366	623	9	to	to	ADP
fnp-4366	623	10	d	d	PROPN
fnp-4366	623	11	)	)	PUNCT
fnp-4366	623	12	.	.	PUNCT
fnp-4366	624	1	b	b	X
fnp-4366	624	2	:	:	PUNCT
fnp-4366	624	3	19	19	NUM
fnp-4366	624	4	-	-	PUNCT
fnp-4366	624	5	year	year	NOUN
fnp-4366	624	6	-	-	PUNCT
fnp-4366	624	7	old	old	ADJ
fnp-4366	624	8	male	male	ADJ
fnp-4366	624	9	patient	patient	NOUN
fnp-4366	624	10	with	with	ADP
fnp-4366	624	11	frontal	frontal	ADJ
fnp-4366	624	12	lobe	lobe	NOUN
fnp-4366	624	13	epilepsy	epilepsy	NOUN
fnp-4366	624	14	since	since	SCONJ
fnp-4366	624	15	age	age	NOUN
fnp-4366	624	16	9	9	NUM
fnp-4366	624	17	years	year	NOUN
fnp-4366	624	18	,	,	PUNCT
fnp-4366	624	19	histopathological	histopathological	ADJ
fnp-4366	624	20	confirmed	confirm	VERB
fnp-4366	624	21	fcd2b	fcd2b	PROPN
fnp-4366	624	22	at	at	ADP
fnp-4366	624	23	a	a	DET
fnp-4366	624	24	bottom	bottom	ADJ
fnp-4366	624	25	-	-	PUNCT
fnp-4366	624	26	of	of	ADP
fnp-4366	624	27	-	-	PUNCT
fnp-4366	624	28	sulcus	sulcus	NOUN
fnp-4366	624	29	(	(	PUNCT
fnp-4366	624	30	bos	bo	NOUN
fnp-4366	624	31	;	;	PUNCT
fnp-4366	624	32	higher	high	ADJ
fnp-4366	624	33	magnification	magnification	NOUN
fnp-4366	624	34	in	in	ADP
fnp-4366	624	35	d	d	PROPN
fnp-4366	624	36	)	)	PUNCT
fnp-4366	624	37	and	and	CCONJ
fnp-4366	624	38	a	a	DET
fnp-4366	624	39	pathogenic	pathogenic	ADJ
fnp-4366	624	40	mtor	mtor	NOUN
fnp-4366	624	41	mosaicism	mosaicism	NOUN
fnp-4366	624	42	.	.	PUNCT
fnp-4366	625	1	dysmorphic	dysmorphic	ADJ
fnp-4366	625	2	neurons	neuron	NOUN
fnp-4366	625	3	and	and	CCONJ
fnp-4366	625	4	balloon	balloon	NOUN
fnp-4366	625	5	cells	cell	NOUN
fnp-4366	625	6	(	(	PUNCT
fnp-4366	625	7	latter	latter	ADV
fnp-4366	625	8	not	not	PART
fnp-4366	625	9	shown	show	VERB
fnp-4366	625	10	)	)	PUNCT
fnp-4366	625	11	were	be	AUX
fnp-4366	625	12	aggregating	aggregate	VERB
fnp-4366	625	13	in	in	ADP
fnp-4366	625	14	the	the	DET
fnp-4366	625	15	neocortex	neocortex	NOUN
fnp-4366	625	16	and	and	CCONJ
fnp-4366	625	17	white	white	ADJ
fnp-4366	625	18	matter	matter	NOUN
fnp-4366	625	19	(	(	PUNCT
fnp-4366	625	20	arrow	arrow	NOUN
fnp-4366	625	21	)	)	PUNCT
fnp-4366	625	22	suggesting	suggest	VERB
fnp-4366	625	23	a	a	DET
fnp-4366	625	24	migration	migration	NOUN
fnp-4366	625	25	deficient	deficient	ADJ
fnp-4366	625	26	phenotype	phenotype	NOUN
fnp-4366	625	27	.	.	PUNCT
fnp-4366	625	28	  	  	SPACE
fnp-4366	626	1	6.02	6.02	NUM
fnp-4366	626	2	free	free	ADJ
fnp-4366	626	3	neuropathol	neuropathol	NOUN
fnp-4366	626	4	3:20:60	3:20:60	NUM
fnp-4366	626	5	age	age	NOUN
fnp-4366	626	6	-	-	PUNCT
fnp-4366	626	7	dependent	dependent	ADJ
fnp-4366	626	8	increase	increase	NOUN
fnp-4366	626	9	of	of	ADP
fnp-4366	626	10	perineuronal	perineuronal	ADJ
fnp-4366	626	11	nets	net	NOUN
fnp-4366	626	12	in	in	ADP
fnp-4366	626	13	the	the	DET
fnp-4366	626	14	human	human	ADJ
fnp-4366	626	15	hippocampus	hippocampus	NOUN
fnp-4366	626	16	of	of	ADP
fnp-4366	626	17	patients	patient	NOUN
fnp-4366	626	18	with	with	ADP
fnp-4366	626	19	and	and	CCONJ
fnp-4366	626	20	without	without	ADP
fnp-4366	626	21	temporal	temporal	ADJ
fnp-4366	626	22	lobe	lobe	ADJ
fnp-4366	626	23	epilepsy	epilepsy	NOUN
fnp-4366	626	24	annika	annika	PROPN
fnp-4366	626	25	lehner1	lehner1	PROPN
fnp-4366	626	26	,	,	PUNCT
fnp-4366	626	27	lucas	lucas	PROPN
fnp-4366	626	28	hoffmann1	hoffmann1	PROPN
fnp-4366	626	29	,	,	PUNCT
fnp-4366	626	30	friedrich	friedrich	PROPN
fnp-4366	626	31	paulsen2	paulsen2	PROPN
fnp-4366	626	32	,	,	PUNCT
fnp-4366	626	33	hajo	hajo	ADV
fnp-4366	626	34	hamer3	hamer3	PROPN
fnp-4366	626	35	,	,	PUNCT
fnp-4366	626	36	katrin	katrin	PROPN
fnp-4366	626	37	walther3	walther3	PROPN
fnp-4366	626	38	,	,	PUNCT
fnp-4366	626	39	karl	karl	PROPN
fnp-4366	626	40	rössler4	rössler4	PROPN
fnp-4366	626	41	,	,	PUNCT
fnp-4366	626	42	sebastian	sebastian	PROPN
fnp-4366	626	43	brandner5	brandner5	PROPN
fnp-4366	626	44	,	,	PUNCT
fnp-4366	626	45	ingmar	ingmar	PROPN
fnp-4366	626	46	blümcke1	blümcke1	PROPN
fnp-4366	626	47	1	1	NUM
fnp-4366	626	48	universitätsklinikum	universitätsklinikum	NOUN
fnp-4366	626	49	erlangen	erlangen	PROPN
fnp-4366	626	50	and	and	CCONJ
fnp-4366	626	51	fau	fau	PROPN
fnp-4366	626	52	erlangen	erlangen	PROPN
fnp-4366	626	53	-	-	PUNCT
fnp-4366	626	54	nürnberg	nürnberg	PROPN
fnp-4366	626	55	,	,	PUNCT
fnp-4366	626	56	department	department	NOUN
fnp-4366	626	57	of	of	ADP
fnp-4366	626	58	neuropathology	neuropathology	NOUN
fnp-4366	626	59	,	,	PUNCT
fnp-4366	626	60	erlangen	erlangen	PROPN
fnp-4366	626	61	,	,	PUNCT
fnp-4366	626	62	deutschland	deutschland	PROPN
fnp-4366	626	63	2	2	NUM
fnp-4366	626	64	fau	fau	PROPN
fnp-4366	626	65	erlangen	erlangen	PROPN
fnp-4366	626	66	-	-	PUNCT
fnp-4366	626	67	nürnberg	nürnberg	PROPN
fnp-4366	626	68	,	,	PUNCT
fnp-4366	626	69	institute	institute	NOUN
fnp-4366	626	70	of	of	ADP
fnp-4366	626	71	functional	functional	ADJ
fnp-4366	626	72	and	and	CCONJ
fnp-4366	626	73	clinical	clinical	ADJ
fnp-4366	626	74	anatomy	anatomy	NOUN
fnp-4366	626	75	,	,	PUNCT
fnp-4366	626	76	erlangen	erlangen	PROPN
fnp-4366	626	77	,	,	PUNCT
fnp-4366	626	78	deutschland	deutschland	NOUN
fnp-4366	626	79	3	3	NUM
fnp-4366	626	80	universitätsklinikum	universitätsklinikum	NOUN
fnp-4366	626	81	erlangen	erlangen	PROPN
fnp-4366	626	82	and	and	CCONJ
fnp-4366	626	83	fau	fau	PROPN
fnp-4366	626	84	erlangen	erlangen	PROPN
fnp-4366	626	85	-	-	PUNCT
fnp-4366	626	86	nürnberg	nürnberg	PROPN
fnp-4366	626	87	,	,	PUNCT
fnp-4366	626	88	epilepsy	epilepsy	NOUN
fnp-4366	626	89	center	center	NOUN
fnp-4366	626	90	,	,	PUNCT
fnp-4366	626	91	neurological	neurological	ADJ
fnp-4366	626	92	institute	institute	NOUN
fnp-4366	626	93	,	,	PUNCT
fnp-4366	626	94	erlangen	erlangen	PROPN
fnp-4366	626	95	,	,	PUNCT
fnp-4366	626	96	deutschland	deutschland	NOUN
fnp-4366	626	97	4	4	NUM
fnp-4366	626	98	medical	medical	ADJ
fnp-4366	626	99	university	university	PROPN
fnp-4366	626	100	of	of	ADP
fnp-4366	626	101	vienna	vienna	PROPN
fnp-4366	626	102	,	,	PUNCT
fnp-4366	626	103	vienna	vienna	PROPN
fnp-4366	626	104	general	general	PROPN
fnp-4366	626	105	hospital	hospital	PROPN
fnp-4366	626	106	,	,	PUNCT
fnp-4366	626	107	department	department	NOUN
fnp-4366	626	108	of	of	ADP
fnp-4366	626	109	neurosurgery	neurosurgery	NOUN
fnp-4366	626	110	,	,	PUNCT
fnp-4366	626	111	vienna	vienna	PROPN
fnp-4366	626	112	,	,	PUNCT
fnp-4366	626	113	austria	austria	PROPN
fnp-4366	626	114	5	5	NUM
fnp-4366	626	115	universitätsklinikum	universitätsklinikum	NOUN
fnp-4366	626	116	erlangen	erlangen	PROPN
fnp-4366	626	117	and	and	CCONJ
fnp-4366	626	118	fau	fau	PROPN
fnp-4366	626	119	erlangen	erlangen	PROPN
fnp-4366	626	120	-	-	PUNCT
fnp-4366	626	121	nürnberg	nürnberg	PROPN
fnp-4366	626	122	,	,	PUNCT
fnp-4366	626	123	department	department	NOUN
fnp-4366	626	124	of	of	ADP
fnp-4366	626	125	neurosurgery	neurosurgery	NOUN
fnp-4366	626	126	,	,	PUNCT
fnp-4366	626	127	erlangen	erlangen	PROPN
fnp-4366	626	128	,	,	PUNCT
fnp-4366	626	129	deutschland	deutschland	NOUN
fnp-4366	626	130	background	background	NOUN
fnp-4366	626	131	:	:	PUNCT
fnp-4366	626	132	perineuronal	perineuronal	ADJ
fnp-4366	626	133	nets	net	NOUN
fnp-4366	626	134	(	(	PUNCT
fnp-4366	626	135	pnn	pnn	NOUN
fnp-4366	626	136	)	)	PUNCT
fnp-4366	626	137	are	be	AUX
fnp-4366	626	138	a	a	DET
fnp-4366	626	139	specialized	specialized	ADJ
fnp-4366	626	140	extracellular	extracellular	ADJ
fnp-4366	626	141	matrix	matrix	NOUN
fnp-4366	626	142	surrounding	surround	VERB
fnp-4366	626	143	parvalbumin	parvalbumin	ADJ
fnp-4366	626	144	-	-	PUNCT
fnp-4366	626	145	positive	positive	ADJ
fnp-4366	626	146	gabaergic	gabaergic	ADJ
fnp-4366	626	147	interneurons	interneuron	NOUN
fnp-4366	626	148	of	of	ADP
fnp-4366	626	149	the	the	DET
fnp-4366	626	150	central	central	ADJ
fnp-4366	626	151	nervous	nervous	ADJ
fnp-4366	626	152	system	system	NOUN
fnp-4366	626	153	,	,	PUNCT
fnp-4366	626	154	contain	contain	VERB
fnp-4366	626	155	mainly	mainly	ADV
fnp-4366	626	156	aggrecan	aggrecan	ADJ
fnp-4366	626	157	and	and	CCONJ
fnp-4366	626	158	lecticans	lectican	NOUN
fnp-4366	626	159	,	,	PUNCT
fnp-4366	626	160	and	and	CCONJ
fnp-4366	626	161	play	play	VERB
fnp-4366	626	162	a	a	DET
fnp-4366	626	163	role	role	NOUN
fnp-4366	626	164	in	in	ADP
fnp-4366	626	165	the	the	DET
fnp-4366	626	166	regulation	regulation	NOUN
fnp-4366	626	167	of	of	ADP
fnp-4366	626	168	synaptic	synaptic	ADJ
fnp-4366	626	169	plasticity	plasticity	NOUN
fnp-4366	626	170	,	,	PUNCT
fnp-4366	626	171	brain	brain	NOUN
fnp-4366	626	172	maturation	maturation	NOUN
fnp-4366	626	173	and	and	CCONJ
fnp-4366	626	174	cognitive	cognitive	ADJ
fnp-4366	626	175	impairment	impairment	NOUN
fnp-4366	626	176	.	.	PUNCT
fnp-4366	627	1	in	in	ADP
fnp-4366	627	2	the	the	DET
fnp-4366	627	3	human	human	ADJ
fnp-4366	627	4	neocortex	neocortex	NOUN
fnp-4366	627	5	,	,	PUNCT
fnp-4366	627	6	pnn	pnn	PROPN
fnp-4366	627	7	appear	appear	VERB
fnp-4366	627	8	in	in	ADP
fnp-4366	627	9	their	their	PRON
fnp-4366	627	10	full	full	ADJ
fnp-4366	627	11	expression	expression	NOUN
fnp-4366	627	12	at	at	ADP
fnp-4366	627	13	an	an	DET
fnp-4366	627	14	age	age	NOUN
fnp-4366	627	15	of	of	ADP
fnp-4366	627	16	eight	eight	NUM
fnp-4366	627	17	,	,	PUNCT
fnp-4366	627	18	and	and	CCONJ
fnp-4366	627	19	alterations	alteration	NOUN
fnp-4366	627	20	of	of	ADP
fnp-4366	627	21	pnn	pnn	PROPN
fnp-4366	627	22	have	have	AUX
fnp-4366	627	23	been	be	AUX
fnp-4366	627	24	found	find	VERB
fnp-4366	627	25	in	in	ADP
fnp-4366	627	26	neurological	neurological	ADJ
fnp-4366	627	27	disorders	disorder	NOUN
fnp-4366	627	28	including	include	VERB
fnp-4366	627	29	alzheimer´s	alzheimer´s	NOUN
fnp-4366	627	30	disease	disease	NOUN
fnp-4366	627	31	,	,	PUNCT
fnp-4366	627	32	schizophrenia	schizophrenia	NOUN
fnp-4366	627	33	or	or	CCONJ
fnp-4366	627	34	epilepsy	epilepsy	NOUN
fnp-4366	627	35	.	.	PUNCT
fnp-4366	628	1	however	however	ADV
fnp-4366	628	2	,	,	PUNCT
fnp-4366	628	3	their	their	PRON
fnp-4366	628	4	role	role	NOUN
fnp-4366	628	5	in	in	ADP
fnp-4366	628	6	functional	functional	ADJ
fnp-4366	628	7	maintenance	maintenance	NOUN
fnp-4366	628	8	of	of	ADP
fnp-4366	628	9	the	the	DET
fnp-4366	628	10	cns	cns	NOUN
fnp-4366	628	11	as	as	ADV
fnp-4366	628	12	well	well	ADV
fnp-4366	628	13	as	as	ADP
fnp-4366	628	14	disease	disease	NOUN
fnp-4366	628	15	pathogenesis	pathogenesis	NOUN
fnp-4366	628	16	remains	remain	VERB
fnp-4366	628	17	to	to	PART
fnp-4366	628	18	be	be	AUX
fnp-4366	628	19	elucidated	elucidate	VERB
fnp-4366	628	20	.	.	PUNCT
fnp-4366	629	1	aim	aim	VERB
fnp-4366	629	2	:	:	PUNCT
fnp-4366	629	3	our	our	PRON
fnp-4366	629	4	aim	aim	NOUN
fnp-4366	629	5	was	be	AUX
fnp-4366	629	6	to	to	PART
fnp-4366	629	7	histopathologically	histopathologically	ADV
fnp-4366	629	8	assess	assess	VERB
fnp-4366	629	9	pnn	pnn	PROPN
fnp-4366	629	10	in	in	ADP
fnp-4366	629	11	the	the	DET
fnp-4366	629	12	hippocampus	hippocampus	NOUN
fnp-4366	629	13	of	of	ADP
fnp-4366	629	14	patients	patient	NOUN
fnp-4366	629	15	with	with	ADP
fnp-4366	629	16	temporal	temporal	ADJ
fnp-4366	629	17	lobe	lobe	ADJ
fnp-4366	629	18	epilepsy	epilepsy	NOUN
fnp-4366	629	19	(	(	PUNCT
fnp-4366	629	20	tle	tle	ADJ
fnp-4366	629	21	)	)	PUNCT
fnp-4366	629	22	compared	compare	VERB
fnp-4366	629	23	to	to	ADP
fnp-4366	629	24	age	age	NOUN
fnp-4366	629	25	-	-	PUNCT
fnp-4366	629	26	matched	match	VERB
fnp-4366	629	27	post	post	ADJ
fnp-4366	629	28	-	-	ADJ
fnp-4366	629	29	mortem	mortem	ADJ
fnp-4366	629	30	control	control	NOUN
fnp-4366	629	31	subjects	subject	NOUN
fnp-4366	629	32	.	.	PUNCT
fnp-4366	630	1	methods	method	NOUN
fnp-4366	630	2	:	:	PUNCT
fnp-4366	630	3	formalin	formalin	NOUN
fnp-4366	630	4	-	-	PUNCT
fnp-4366	630	5	fixed	fix	VERB
fnp-4366	630	6	and	and	CCONJ
fnp-4366	630	7	paraffin	paraffin	NOUN
fnp-4366	630	8	-	-	PUNCT
fnp-4366	630	9	embedded	embed	VERB
fnp-4366	630	10	neurosurgical	neurosurgical	ADJ
fnp-4366	630	11	tissue	tissue	NOUN
fnp-4366	630	12	specimens	specimen	NOUN
fnp-4366	630	13	of	of	ADP
fnp-4366	630	14	the	the	DET
fnp-4366	630	15	human	human	ADJ
fnp-4366	630	16	hippocampus	hippocampus	NOUN
fnp-4366	630	17	were	be	AUX
fnp-4366	630	18	retrieved	retrieve	VERB
fnp-4366	630	19	from	from	ADP
fnp-4366	630	20	the	the	DET
fnp-4366	630	21	european	european	ADJ
fnp-4366	630	22	epilepsy	epilepsy	PROPN
fnp-4366	630	23	brain	brain	NOUN
fnp-4366	630	24	bank	bank	PROPN
fnp-4366	630	25	.	.	PUNCT
fnp-4366	631	1	twenty	twenty	NUM
fnp-4366	631	2	-	-	PUNCT
fnp-4366	631	3	nine	nine	NUM
fnp-4366	631	4	patients	patient	NOUN
fnp-4366	631	5	had	have	AUX
fnp-4366	631	6	histopathologically	histopathologically	ADV
fnp-4366	631	7	confirmed	confirm	VERB
fnp-4366	631	8	hippocampal	hippocampal	ADJ
fnp-4366	631	9	sclerosis	sclerosis	NOUN
fnp-4366	631	10	(	(	PUNCT
fnp-4366	631	11	hs	hs	X
fnp-4366	631	12	)	)	PUNCT
fnp-4366	631	13	,	,	PUNCT
fnp-4366	631	14	and	and	CCONJ
fnp-4366	631	15	11	11	NUM
fnp-4366	631	16	patients	patient	NOUN
fnp-4366	631	17	suffered	suffer	VERB
fnp-4366	631	18	from	from	ADP
fnp-4366	631	19	tle	tle	NOUN
fnp-4366	631	20	with	with	ADP
fnp-4366	631	21	no	no	DET
fnp-4366	631	22	hs	hs	PROPN
fnp-4366	631	23	.	.	PROPN
fnp-4366	631	24	neuropsychology	neuropsychology	NOUN
fnp-4366	631	25	scores	score	NOUN
fnp-4366	631	26	for	for	ADP
fnp-4366	631	27	cognitive	cognitive	ADJ
fnp-4366	631	28	tasks	task	NOUN
fnp-4366	631	29	were	be	AUX
fnp-4366	631	30	retrieved	retrieve	VERB
fnp-4366	631	31	from	from	ADP
fnp-4366	631	32	the	the	DET
fnp-4366	631	33	files	file	NOUN
fnp-4366	631	34	of	of	ADP
fnp-4366	631	35	the	the	DET
fnp-4366	631	36	erlangen	erlangen	PROPN
fnp-4366	631	37	epilepsy	epilepsy	PROPN
fnp-4366	631	38	center	center	NOUN
fnp-4366	631	39	.	.	PUNCT
fnp-4366	632	1	hippocampus	hippocampus	NOUN
fnp-4366	632	2	samples	sample	NOUN
fnp-4366	632	3	of	of	ADP
fnp-4366	632	4	27	27	NUM
fnp-4366	632	5	postmortem	postmortem	NOUN
fnp-4366	632	6	brains	brain	NOUN
fnp-4366	632	7	served	serve	VERB
fnp-4366	632	8	as	as	ADP
fnp-4366	632	9	control	control	NOUN
fnp-4366	632	10	(	(	PUNCT
fnp-4366	632	11	age	age	NOUN
fnp-4366	632	12	range	range	NOUN
fnp-4366	632	13	3	3	NUM
fnp-4366	632	14	-	-	SYM
fnp-4366	632	15	84	84	NUM
fnp-4366	632	16	)	)	PUNCT
fnp-4366	632	17	.	.	PUNCT
fnp-4366	633	1	pnn	pnn	PROPN
fnp-4366	633	2	were	be	AUX
fnp-4366	633	3	visualized	visualize	VERB
fnp-4366	633	4	using	use	VERB
fnp-4366	633	5	antibodies	antibody	NOUN
fnp-4366	633	6	directed	direct	VERB
fnp-4366	633	7	against	against	ADP
fnp-4366	633	8	aggrecan	aggrecan	PROPN
fnp-4366	633	9	(	(	PUNCT
fnp-4366	633	10	figure	figure	NOUN
fnp-4366	633	11	1	1	NUM
fnp-4366	633	12	)	)	PUNCT
fnp-4366	633	13	.	.	PUNCT
fnp-4366	634	1	pnn	pnn	PROPN
fnp-4366	634	2	were	be	AUX
fnp-4366	634	3	manually	manually	ADV
fnp-4366	634	4	recorded	record	VERB
fnp-4366	634	5	in	in	ADP
fnp-4366	634	6	the	the	DET
fnp-4366	634	7	dentate	dentate	ADJ
fnp-4366	634	8	gyrus	gyrus	NOUN
fnp-4366	634	9	,	,	PUNCT
fnp-4366	634	10	ca1	ca1	PROPN
fnp-4366	634	11	,	,	PUNCT
fnp-4366	634	12	ca2	ca2	PROPN
fnp-4366	634	13	,	,	PUNCT
fnp-4366	634	14	ca3	ca3	NOUN
fnp-4366	634	15	,	,	PUNCT
fnp-4366	634	16	ca4	ca4	NOUN
fnp-4366	634	17	and	and	CCONJ
fnp-4366	634	18	subiculum	subiculum	NOUN
fnp-4366	634	19	.	.	PUNCT
fnp-4366	635	1	pnn	pnn	PROPN
fnp-4366	635	2	density	density	PROPN
fnp-4366	635	3	per	per	ADP
fnp-4366	635	4	mm²	mm²	NOUN
fnp-4366	635	5	was	be	AUX
fnp-4366	635	6	then	then	ADV
fnp-4366	635	7	compared	compare	VERB
fnp-4366	635	8	between	between	ADP
fnp-4366	635	9	different	different	ADJ
fnp-4366	635	10	hs	hs	PROPN
fnp-4366	635	11	subtypes	subtype	NOUN
fnp-4366	635	12	according	accord	VERB
fnp-4366	635	13	to	to	ADP
fnp-4366	635	14	the	the	DET
fnp-4366	635	15	ilae	ilae	NOUN
fnp-4366	635	16	classification	classification	NOUN
fnp-4366	635	17	scheme	scheme	NOUN
fnp-4366	635	18	and	and	CCONJ
fnp-4366	635	19	controls	control	NOUN
fnp-4366	635	20	.	.	PUNCT
fnp-4366	636	1	selected	select	VERB
fnp-4366	636	2	cases	case	NOUN
fnp-4366	636	3	were	be	AUX
fnp-4366	636	4	double	double	ADJ
fnp-4366	636	5	immunofluorescence	immunofluorescence	NOUN
fnp-4366	636	6	labeled	label	VERB
fnp-4366	636	7	with	with	ADP
fnp-4366	636	8	antibodies	antibody	NOUN
fnp-4366	636	9	against	against	ADP
fnp-4366	636	10	parvalbumin	parvalbumin	NOUN
fnp-4366	636	11	and	and	CCONJ
fnp-4366	636	12	aggrecan	aggrecan	ADJ
fnp-4366	636	13	(	(	PUNCT
fnp-4366	636	14	figure	figure	NOUN
fnp-4366	636	15	1	1	NUM
fnp-4366	636	16	)	)	PUNCT
fnp-4366	636	17	and	and	CCONJ
fnp-4366	636	18	further	far	ADV
fnp-4366	636	19	analyzed	analyze	VERB
fnp-4366	636	20	on	on	ADP
fnp-4366	636	21	fully	fully	ADV
fnp-4366	636	22	digitalized	digitalize	VERB
fnp-4366	636	23	scans	scan	NOUN
fnp-4366	636	24	(	(	PUNCT
fnp-4366	636	25	hamamtsu	hamamtsu	NOUN
fnp-4366	636	26	nanozoomer	nanozoomer	PROPN
fnp-4366	636	27	s60	s60	PROPN
fnp-4366	636	28	)	)	PUNCT
fnp-4366	636	29	with	with	ADP
fnp-4366	636	30	qupath	qupath	NOUN
fnp-4366	636	31	0.3.0	0.3.0	NOUN
fnp-4366	636	32	.	.	PUNCT
fnp-4366	637	1	results	result	NOUN
fnp-4366	637	2	:	:	PUNCT
fnp-4366	637	3	the	the	DET
fnp-4366	637	4	density	density	NOUN
fnp-4366	637	5	of	of	ADP
fnp-4366	637	6	pnn	pnn	PROPN
fnp-4366	637	7	increased	increase	VERB
fnp-4366	637	8	with	with	ADP
fnp-4366	637	9	age	age	NOUN
fnp-4366	637	10	in	in	ADP
fnp-4366	637	11	both	both	PRON
fnp-4366	637	12	,	,	PUNCT
fnp-4366	637	13	human	human	ADJ
fnp-4366	637	14	controls	control	NOUN
fnp-4366	637	15	and	and	CCONJ
fnp-4366	637	16	tle	tle	VERB
fnp-4366	637	17	patients	patient	NOUN
fnp-4366	637	18	(	(	PUNCT
fnp-4366	637	19	figure	figure	NOUN
fnp-4366	637	20	2	2	NUM
fnp-4366	637	21	)	)	PUNCT
fnp-4366	637	22	.	.	PUNCT
fnp-4366	638	1	however	however	ADV
fnp-4366	638	2	,	,	PUNCT
fnp-4366	638	3	the	the	DET
fnp-4366	638	4	density	density	NOUN
fnp-4366	638	5	of	of	ADP
fnp-4366	638	6	pnn	pnn	PROPN
fnp-4366	638	7	was	be	AUX
fnp-4366	638	8	significantly	significantly	ADV
fnp-4366	638	9	higher	high	ADJ
fnp-4366	638	10	in	in	ADP
fnp-4366	638	11	all	all	DET
fnp-4366	638	12	tle	tle	ADJ
fnp-4366	638	13	patients	patient	NOUN
fnp-4366	638	14	compared	compare	VERB
fnp-4366	638	15	to	to	ADP
fnp-4366	638	16	age	age	NOUN
fnp-4366	638	17	-	-	PUNCT
fnp-4366	638	18	matched	match	VERB
fnp-4366	638	19	controls	control	NOUN
fnp-4366	638	20	with	with	ADP
fnp-4366	638	21	a	a	DET
fnp-4366	638	22	non	non	ADJ
fnp-4366	638	23	-	-	ADJ
fnp-4366	638	24	significant	significant	ADJ
fnp-4366	638	25	increase	increase	NOUN
fnp-4366	638	26	in	in	ADP
fnp-4366	638	27	patients	patient	NOUN
fnp-4366	638	28	with	with	ADP
fnp-4366	638	29	hippocampal	hippocampal	ADJ
fnp-4366	638	30	sclerosis	sclerosis	NOUN
fnp-4366	638	31	compared	compare	VERB
fnp-4366	638	32	to	to	PART
fnp-4366	638	33	tle	tle	VERB
fnp-4366	638	34	patients	patient	NOUN
fnp-4366	638	35	without	without	ADP
fnp-4366	638	36	hs	hs	PROPN
fnp-4366	638	37	.	.	PUNCT
fnp-4366	639	1	these	these	DET
fnp-4366	639	2	alterations	alteration	NOUN
fnp-4366	639	3	were	be	AUX
fnp-4366	639	4	also	also	ADV
fnp-4366	639	5	region	region	NOUN
fnp-4366	639	6	-	-	PUNCT
fnp-4366	639	7	specific	specific	ADJ
fnp-4366	639	8	and	and	CCONJ
fnp-4366	639	9	most	most	ADV
fnp-4366	639	10	obvious	obvious	ADJ
fnp-4366	639	11	in	in	ADP
fnp-4366	639	12	the	the	DET
fnp-4366	639	13	subiculum	subiculum	NOUN
fnp-4366	639	14	,	,	PUNCT
fnp-4366	639	15	ca1	ca1	NOUN
fnp-4366	639	16	and	and	CCONJ
fnp-4366	639	17	dentate	dentate	ADJ
fnp-4366	639	18	gyrus	gyrus	NOUN
fnp-4366	639	19	(	(	PUNCT
fnp-4366	639	20	figure	figure	NOUN
fnp-4366	639	21	3	3	NUM
fnp-4366	639	22	)	)	PUNCT
fnp-4366	639	23	.	.	PUNCT
fnp-4366	640	1	there	there	PRON
fnp-4366	640	2	was	be	VERB
fnp-4366	640	3	no	no	DET
fnp-4366	640	4	significant	significant	ADJ
fnp-4366	640	5	correlation	correlation	NOUN
fnp-4366	640	6	with	with	ADP
fnp-4366	640	7	cognitive	cognitive	ADJ
fnp-4366	640	8	impairment	impairment	NOUN
fnp-4366	640	9	in	in	ADP
fnp-4366	640	10	our	our	PRON
fnp-4366	640	11	cohort	cohort	NOUN
fnp-4366	640	12	of	of	ADP
fnp-4366	640	13	tle	tle	NOUN
fnp-4366	640	14	patients	patient	NOUN
fnp-4366	640	15	.	.	PUNCT
fnp-4366	641	1	discussion	discussion	NOUN
fnp-4366	641	2	:	:	PUNCT
fnp-4366	641	3	we	we	PRON
fnp-4366	641	4	quantitatively	quantitatively	ADV
fnp-4366	641	5	described	describe	VERB
fnp-4366	641	6	the	the	DET
fnp-4366	641	7	normal	normal	ADJ
fnp-4366	641	8	distribution	distribution	NOUN
fnp-4366	641	9	of	of	ADP
fnp-4366	641	10	pnn	pnn	PROPN
fnp-4366	641	11	in	in	ADP
fnp-4366	641	12	the	the	DET
fnp-4366	641	13	human	human	ADJ
fnp-4366	641	14	hippocampal	hippocampal	ADJ
fnp-4366	641	15	formation	formation	NOUN
fnp-4366	641	16	.	.	PUNCT
fnp-4366	642	1	we	we	PRON
fnp-4366	642	2	investigated	investigate	VERB
fnp-4366	642	3	changes	change	NOUN
fnp-4366	642	4	with	with	ADP
fnp-4366	642	5	age	age	NOUN
fnp-4366	642	6	in	in	ADP
fnp-4366	642	7	the	the	DET
fnp-4366	642	8	number	number	NOUN
fnp-4366	642	9	of	of	ADP
fnp-4366	642	10	perineuronal	perineuronal	ADJ
fnp-4366	642	11	nets	net	NOUN
fnp-4366	642	12	in	in	ADP
fnp-4366	642	13	older	old	ADJ
fnp-4366	642	14	patients	patient	NOUN
fnp-4366	642	15	and	and	CCONJ
fnp-4366	642	16	found	find	VERB
fnp-4366	642	17	new	new	ADJ
fnp-4366	642	18	evidence	evidence	NOUN
fnp-4366	642	19	that	that	PRON
fnp-4366	642	20	epilepsy	epilepsy	NOUN
fnp-4366	642	21	alters	alter	VERB
fnp-4366	642	22	perineuronal	perineuronal	ADJ
fnp-4366	642	23	nets	net	NOUN
fnp-4366	642	24	.	.	PUNCT
fnp-4366	643	1	figure	figure	NOUN
fnp-4366	643	2	1	1	NUM
fnp-4366	643	3	:	:	PUNCT
fnp-4366	643	4	triple	triple	ADJ
fnp-4366	643	5	immunofluorescence	immunofluorescence	NOUN
fnp-4366	643	6	-	-	PUNCT
fnp-4366	643	7	staining	stain	VERB
fnp-4366	643	8	at	at	ADP
fnp-4366	643	9	40x	40x	NOUN
fnp-4366	643	10	magnification	magnification	NOUN
fnp-4366	643	11	:	:	PUNCT
fnp-4366	643	12	a	a	DET
fnp-4366	643	13	parvalbumin	parvalbumin	ADJ
fnp-4366	643	14	-	-	PUNCT
fnp-4366	643	15	positive	positive	ADJ
fnp-4366	643	16	neuron	neuron	NOUN
fnp-4366	643	17	surrounded	surround	VERB
fnp-4366	643	18	by	by	ADP
fnp-4366	643	19	aggrecan	aggrecan	PROPN
fnp-4366	643	20	(	(	PUNCT
fnp-4366	643	21	left	leave	VERB
fnp-4366	643	22	side	side	NOUN
fnp-4366	643	23	)	)	PUNCT
fnp-4366	643	24	.	.	PUNCT
fnp-4366	644	1	immunohistochemical	immunohistochemical	ADJ
fnp-4366	644	2	staining	staining	NOUN
fnp-4366	644	3	of	of	ADP
fnp-4366	644	4	a	a	DET
fnp-4366	644	5	pnn	pnn	NOUN
fnp-4366	644	6	in	in	ADP
fnp-4366	644	7	the	the	DET
fnp-4366	644	8	stratum	stratum	NOUN
fnp-4366	644	9	plexiforme	plexiforme	VERB
fnp-4366	644	10	of	of	ADP
fnp-4366	644	11	the	the	DET
fnp-4366	644	12	dentate	dentate	ADJ
fnp-4366	644	13	gyrus	gyrus	NOUN
fnp-4366	644	14	(	(	PUNCT
fnp-4366	644	15	150	150	NUM
fnp-4366	644	16	µm	µm	NOUN
fnp-4366	644	17	away	away	ADV
fnp-4366	644	18	from	from	ADP
fnp-4366	644	19	stratum	stratum	PROPN
fnp-4366	644	20	granulosum	granulosum	NOUN
fnp-4366	644	21	)	)	PUNCT
fnp-4366	644	22	,	,	PUNCT
fnp-4366	644	23	screenshot	screenshot	NOUN
fnp-4366	644	24	from	from	ADP
fnp-4366	644	25	qupath	qupath	NOUN
fnp-4366	644	26	,	,	PUNCT
fnp-4366	644	27	40x	40x	NOUN
fnp-4366	644	28	magnification	magnification	NOUN
fnp-4366	644	29	(	(	PUNCT
fnp-4366	644	30	right	right	ADJ
fnp-4366	644	31	side	side	NOUN
fnp-4366	644	32	)	)	PUNCT
fnp-4366	644	33	.	.	PUNCT
fnp-4366	645	1	figure	figure	VERB
fnp-4366	645	2	2	2	NUM
fnp-4366	645	3	:	:	PUNCT
fnp-4366	645	4	correlation	correlation	NOUN
fnp-4366	645	5	between	between	ADP
fnp-4366	645	6	the	the	DET
fnp-4366	645	7	age	age	NOUN
fnp-4366	645	8	and	and	CCONJ
fnp-4366	645	9	the	the	DET
fnp-4366	645	10	average	average	ADJ
fnp-4366	645	11	number	number	NOUN
fnp-4366	645	12	of	of	ADP
fnp-4366	645	13	pnn	pnn	PROPN
fnp-4366	645	14	per	per	ADP
fnp-4366	645	15	mm²	mm²	PROPN
fnp-4366	645	16	in	in	ADP
fnp-4366	645	17	patients	patient	NOUN
fnp-4366	645	18	with	with	ADP
fnp-4366	645	19	and	and	CCONJ
fnp-4366	645	20	without	without	ADP
fnp-4366	645	21	epilepsy	epilepsy	NOUN
fnp-4366	645	22	figure	figure	NOUN
fnp-4366	645	23	3	3	NUM
fnp-4366	645	24	:	:	PUNCT
fnp-4366	645	25	the	the	DET
fnp-4366	645	26	normal	normal	ADJ
fnp-4366	645	27	distribution	distribution	NOUN
fnp-4366	645	28	of	of	ADP
fnp-4366	645	29	pnn	pnn	PROPN
fnp-4366	645	30	and	and	CCONJ
fnp-4366	645	31	alterations	alteration	NOUN
fnp-4366	645	32	in	in	ADP
fnp-4366	645	33	epilepsy	epilepsy	NOUN
fnp-4366	645	34	  	  	SPACE
fnp-4366	645	35	6.03	6.03	NUM
fnp-4366	645	36	free	free	ADJ
fnp-4366	645	37	neuropathol	neuropathol	NOUN
fnp-4366	645	38	3:20:63	3:20:63	NUM
fnp-4366	645	39	vakuolisierung	vakuolisierung	ADJ
fnp-4366	645	40	der	der	ADJ
fnp-4366	645	41	dura	dura	NOUN
fnp-4366	645	42	als	als	VERB
fnp-4366	645	43	nicht	nicht	NOUN
fnp-4366	645	44	-	-	PUNCT
fnp-4366	645	45	lymphassoziierte	lymphassoziierte	NOUN
fnp-4366	645	46	veränderung	veränderung	PROPN
fnp-4366	645	47	ralf	ralf	PROPN
fnp-4366	645	48	schober1	schober1	PROPN
fnp-4366	645	49	,	,	PUNCT
fnp-4366	645	50	christian	christian	PROPN
fnp-4366	645	51	eisenlöffel1	eisenlöffel1	PROPN
fnp-4366	645	52	,	,	PUNCT
fnp-4366	645	53	max	max	PROPN
fnp-4366	645	54	holzer2	holzer2	PROPN
fnp-4366	645	55	1	1	NUM
fnp-4366	645	56	klinikum	klinikum	PROPN
fnp-4366	645	57	st	st	PROPN
fnp-4366	645	58	.	.	PROPN
fnp-4366	645	59	georg	georg	PROPN
fnp-4366	645	60	,	,	PUNCT
fnp-4366	645	61	inst	inst	PROPN
fnp-4366	645	62	.	.	PUNCT
fnp-4366	646	1	f.	f.	PROPN
fnp-4366	646	2	pathologie	pathologie	PROPN
fnp-4366	646	3	u.	u.	PROPN
fnp-4366	646	4	tumordiagnostik	tumordiagnostik	PROPN
fnp-4366	646	5	,	,	PUNCT
fnp-4366	646	6	leipzig	leipzig	NOUN
fnp-4366	646	7	,	,	PUNCT
fnp-4366	646	8	deutschlandy	deutschlandy	ADJ
fnp-4366	646	9	2	2	NUM
fnp-4366	646	10	paul	paul	PROPN
fnp-4366	646	11	-	-	PUNCT
fnp-4366	646	12	flechsig	flechsig	PROPN
fnp-4366	646	13	-	-	PUNCT
fnp-4366	646	14	institut	institut	PROPN
fnp-4366	646	15	für	für	PROPN
fnp-4366	646	16	hirnforschung	hirnforschung	PROPN
fnp-4366	646	17	,	,	PUNCT
fnp-4366	646	18	univ	univ	PROPN
fnp-4366	646	19	.	.	PUNCT
fnp-4366	647	1	leipzig	leipzig	PROPN
fnp-4366	647	2	,	,	PUNCT
fnp-4366	647	3	leipzig	leipzig	PROPN
fnp-4366	647	4	,	,	PUNCT
fnp-4366	647	5	deutschland	deutschland	NOUN
fnp-4366	647	6	die	die	VERB
fnp-4366	647	7	meningealen	meningealen	PROPN
fnp-4366	647	8	lymphgefäße	lymphgefäße	PROPN
fnp-4366	647	9	stellen	stellen	PROPN
fnp-4366	647	10	eine	eine	PROPN
fnp-4366	647	11	zwischenstation	zwischenstation	PROPN
fnp-4366	647	12	beim	beim	PROPN
fnp-4366	647	13	abtransport	abtransport	PROPN
fnp-4366	647	14	des	des	PROPN
fnp-4366	647	15	liquors	liquors	PROPN
fnp-4366	647	16	vom	vom	VERB
fnp-4366	647	17	glymphatischen	glymphatischen	ADV
fnp-4366	647	18	system	system	PROPN
fnp-4366	647	19	des	des	X
fnp-4366	647	20	gehirns	gehirn	VERB
fnp-4366	647	21	zu	zu	X
fnp-4366	647	22	den	den	PROPN
fnp-4366	647	23	zervikalen	zervikalen	PROPN
fnp-4366	647	24	lymphknoten	lymphknoten	PROPN
fnp-4366	647	25	dar	dar	PROPN
fnp-4366	647	26	(	(	PUNCT
fnp-4366	647	27	louveau	louveau	VERB
fnp-4366	647	28	j	j	PROPN
fnp-4366	647	29	ea	ea	PROPN
fnp-4366	647	30	2015	2015	NUM
fnp-4366	647	31	,	,	PUNCT
fnp-4366	647	32	aspelund	aspelund	NOUN
fnp-4366	647	33	a	a	DET
fnp-4366	647	34	ea	ea	NOUN
fnp-4366	647	35	2015	2015	NUM
fnp-4366	647	36	)	)	PUNCT
fnp-4366	647	37	.	.	PUNCT
fnp-4366	648	1	sie	sie	PROPN
fnp-4366	648	2	gelten	gelten	VERB
fnp-4366	648	3	als	als	VERB
fnp-4366	648	4	wichtiges	wichtige	VERB
fnp-4366	648	5	immun	immun	PROPN
fnp-4366	648	6	-	-	PUNCT
fnp-4366	648	7	portal	portal	PROPN
fnp-4366	648	8	für	für	PROPN
fnp-4366	648	9	das	das	PROPN
fnp-4366	648	10	zentrale	zentrale	PROPN
fnp-4366	648	11	nervensystem	nervensystem	NOUN
fnp-4366	648	12	(	(	PUNCT
fnp-4366	648	13	tavares	tavare	NOUN
fnp-4366	648	14	ga	ga	PROPN
fnp-4366	648	15	u.	u.	PROPN
fnp-4366	648	16	louveau	louveau	VERB
fnp-4366	648	17	a	a	DET
fnp-4366	648	18	2021	2021	NUM
fnp-4366	648	19	)	)	PUNCT
fnp-4366	648	20	,	,	PUNCT
fnp-4366	648	21	und	und	PROPN
fnp-4366	648	22	eine	eine	PROPN
fnp-4366	648	23	verlegung	verlegung	PROPN
fnp-4366	648	24	des	des	PROPN
fnp-4366	648	25	glymphatischen	glymphatischen	PROPN
fnp-4366	648	26	systems	systems	PROPN
fnp-4366	648	27	wird	wird	PROPN
fnp-4366	648	28	pathogenetisch	pathogenetisch	PROPN
fnp-4366	648	29	mit	mit	PROPN
fnp-4366	648	30	der	der	PROPN
fnp-4366	648	31	demenz	demenz	PROPN
fnp-4366	648	32	und	und	NOUN
fnp-4366	648	33	insbesondere	insbesondere	ADV
fnp-4366	648	34	der	der	NOUN
fnp-4366	648	35	alzheimer'schen	alzheimer'schen	ADV
fnp-4366	648	36	erkrankung	erkrankung	PROPN
fnp-4366	648	37	in	in	ADP
fnp-4366	648	38	verbindung	verbindung	PROPN
fnp-4366	648	39	gebracht	gebracht	PROPN
fnp-4366	648	40	(	(	PUNCT
fnp-4366	648	41	nedergaard	nedergaard	ADV
fnp-4366	648	42	m	m	VERB
fnp-4366	648	43	u.	u.	PROPN
fnp-4366	648	44	goldman	goldman	PROPN
fnp-4366	648	45	sa	sa	PROPN
fnp-4366	648	46	2020	2020	NUM
fnp-4366	648	47	)	)	PUNCT
fnp-4366	648	48	.	.	PUNCT
fnp-4366	649	1	histologische	histologische	PROPN
fnp-4366	649	2	darstellungen	darstellungen	PROPN
fnp-4366	649	3	der	der	PROPN
fnp-4366	649	4	überwiegend	überwiegend	VERB
fnp-4366	649	5	sinus	sinus	NOUN
fnp-4366	649	6	-	-	PUNCT
fnp-4366	649	7	nah	nah	INTJ
fnp-4366	649	8	in	in	ADP
fnp-4366	649	9	der	der	ADJ
fnp-4366	649	10	dura	dura	PROPN
fnp-4366	649	11	gelegenen	gelegenen	PROPN
fnp-4366	649	12	lymphkanäle	lymphkanäle	PROPN
fnp-4366	649	13	beziehen	beziehen	PROPN
fnp-4366	649	14	sich	sich	PROPN
fnp-4366	649	15	bislang	bislang	PROPN
fnp-4366	649	16	hauptsächlich	hauptsächlich	PROPN
fnp-4366	649	17	auf	auf	PROPN
fnp-4366	649	18	die	die	VERB
fnp-4366	649	19	ratte	ratte	PROPN
fnp-4366	649	20	,	,	PUNCT
fnp-4366	649	21	detailliertere	detailliertere	VERB
fnp-4366	649	22	untersuchungen	untersuchungen	PROPN
fnp-4366	649	23	beim	beim	PROPN
fnp-4366	649	24	menschen	menschen	ADV
fnp-4366	649	25	und	und	VERB
fnp-4366	649	26	insbesondere	insbesondere	ADV
fnp-4366	649	27	bei	bei	X
fnp-4366	649	28	verschiedenen	verschiedenen	X
fnp-4366	649	29	erkrankungen	erkrankungen	PROPN
fnp-4366	649	30	stehen	stehen	PROPN
fnp-4366	649	31	noch	noch	PROPN
fnp-4366	649	32	aus	aus	PROPN
fnp-4366	649	33	.	.	PUNCT
fnp-4366	650	1	wir	wir	PROPN
fnp-4366	650	2	haben	haben	NOUN
fnp-4366	650	3	in	in	ADP
fnp-4366	650	4	35	35	NUM
fnp-4366	650	5	sektionsfällen	sektionsfällen	ADJ
fnp-4366	650	6	die	die	VERB
fnp-4366	650	7	dura	dura	NOUN
fnp-4366	650	8	untersucht	untersucht	PROPN
fnp-4366	650	9	,	,	PUNCT
fnp-4366	650	10	meist	meist	NOUN
fnp-4366	650	11	i	i	PROPN
fnp-4366	650	12	m	m	PROPN
fnp-4366	650	13	bereich	bereich	PROPN
fnp-4366	650	14	des	des	PROPN
fnp-4366	650	15	sinus	sinus	PROPN
fnp-4366	650	16	sagittalis	sagittali	VERB
fnp-4366	650	17	superior	superior	ADJ
fnp-4366	650	18	,	,	PUNCT
fnp-4366	650	19	teilweise	teilweise	NOUN
fnp-4366	650	20	zusätzlich	zusätzlich	PROPN
fnp-4366	650	21	des	des	PROPN
fnp-4366	650	22	sinus	sinus	PROPN
fnp-4366	650	23	transversus	transversus	NOUN
fnp-4366	650	24	.	.	PUNCT
fnp-4366	651	1	das	das	PROPN
fnp-4366	651	2	alter	alter	PROPN
fnp-4366	651	3	der	der	PROPN
fnp-4366	651	4	14	14	NUM
fnp-4366	651	5	weiblichen	weiblichen	NOUN
fnp-4366	651	6	und	und	VERB
fnp-4366	651	7	21	21	NUM
fnp-4366	651	8	männlichen	männlichen	ADV
fnp-4366	651	9	patienten	patienten	VERB
fnp-4366	651	10	und	und	NOUN
fnp-4366	651	11	patientinnen	patientinnen	NOUN
fnp-4366	651	12	betrug	betrug	NOUN
fnp-4366	651	13	25	25	NUM
fnp-4366	651	14	-	-	PUNCT
fnp-4366	651	15	91	91	NUM
fnp-4366	651	16	jahre	jahre	NOUN
fnp-4366	651	17	,	,	PUNCT
fnp-4366	651	18	i	i	PRON
fnp-4366	651	19	m	m	VERB
fnp-4366	651	20	durchschnitt	durchschnitt	VERB
fnp-4366	651	21	69	69	NUM
fnp-4366	651	22	jahre	jahre	NOUN
fnp-4366	651	23	.	.	PUNCT
fnp-4366	652	1	in	in	ADP
fnp-4366	652	2	8	8	NUM
fnp-4366	652	3	fällen	fällen	ADJ
fnp-4366	652	4	war	war	NOUN
fnp-4366	652	5	ein	ein	PROPN
fnp-4366	652	6	morbus	morbus	PROPN
fnp-4366	652	7	alzheimer	alzheimer	PROPN
fnp-4366	652	8	diagnostiziert	diagnostiziert	PROPN
fnp-4366	652	9	worden	worden	PROPN
fnp-4366	652	10	,	,	PUNCT
fnp-4366	652	11	in	in	ADP
fnp-4366	652	12	9	9	NUM
fnp-4366	652	13	fällen	fällen	ADJ
fnp-4366	652	14	alzheimer	alzheimer	ADJ
fnp-4366	652	15	-	-	PUNCT
fnp-4366	652	16	assoziierte	assoziierte	NOUN
fnp-4366	652	17	veränderungen	veränderungen	NOUN
fnp-4366	652	18	,	,	PUNCT
fnp-4366	652	19	in	in	ADP
fnp-4366	652	20	je	je	PROPN
fnp-4366	652	21	einem	einem	PROPN
fnp-4366	652	22	fall	fall	NOUN
fnp-4366	652	23	part	part	NOUN
fnp-4366	652	24	und	und	ADJ
fnp-4366	652	25	morbus	morbus	NOUN
fnp-4366	652	26	parkinson	parkinson	NOUN
fnp-4366	652	27	.	.	PUNCT
fnp-4366	653	1	6	6	NUM
fnp-4366	653	2	fälle	fälle	NOUN
fnp-4366	653	3	hatten	hatten	PROPN
fnp-4366	653	4	meningitische	meningitische	PROPN
fnp-4366	653	5	veränderungen	veränderungen	PROPN
fnp-4366	653	6	,	,	PUNCT
fnp-4366	653	7	2	2	NUM
fnp-4366	653	8	fälle	fälle	NOUN
fnp-4366	653	9	eine	eine	PROPN
fnp-4366	653	10	meningeosis	meningeosis	NOUN
fnp-4366	653	11	carcinomatosa	carcinomatosa	NOUN
fnp-4366	653	12	,	,	PUNCT
fnp-4366	653	13	2	2	NUM
fnp-4366	653	14	fälle	fälle	NOUN
fnp-4366	653	15	eine	eine	PROPN
fnp-4366	653	16	av	av	NOUN
fnp-4366	653	17	-	-	PUNCT
fnp-4366	653	18	fistel	fistel	NOUN
fnp-4366	653	19	,	,	PUNCT
fnp-4366	653	20	3	3	NUM
fnp-4366	653	21	fälle	fälle	NOUN
fnp-4366	653	22	intra-/subdurale	intra-/subdurale	X
fnp-4366	653	23	blutungen	blutungen	PROPN
fnp-4366	653	24	,	,	PUNCT
fnp-4366	653	25	und	und	VERB
fnp-4366	653	26	3	3	NUM
fnp-4366	653	27	fälle	fälle	NOUN
fnp-4366	653	28	eine	eine	NOUN
fnp-4366	653	29	sinusthrombose	sinusthrombose	NOUN
fnp-4366	653	30	.	.	PUNCT
fnp-4366	654	1	i	i	PRON
fnp-4366	654	2	m	m	VERB
fnp-4366	654	3	histologischen	histologischen	PROPN
fnp-4366	654	4	bild	bild	PROPN
fnp-4366	654	5	vorherrschend	vorherrschend	VERB
fnp-4366	654	6	und	und	NOUN
fnp-4366	654	7	in	in	ADP
fnp-4366	654	8	allen	allen	PROPN
fnp-4366	654	9	außer	außer	PROPN
fnp-4366	654	10	3	3	NUM
fnp-4366	654	11	fällen	fällen	PROPN
fnp-4366	654	12	nachweisbar	nachweisbar	PROPN
fnp-4366	654	13	waren	waren	PROPN
fnp-4366	654	14	jedoch	jedoch	PROPN
fnp-4366	654	15	nicht	nicht	PROPN
fnp-4366	654	16	die	die	VERB
fnp-4366	654	17	lymphgefäße	lymphgefäße	PROPN
fnp-4366	654	18	,	,	PUNCT
fnp-4366	654	19	sondern	sondern	NOUN
fnp-4366	654	20	gruppen	gruppen	NOUN
fnp-4366	654	21	kleiner	kleiner	PROPN
fnp-4366	654	22	intraduraler	intraduraler	PROPN
fnp-4366	654	23	vakuolen	vakuolen	PROPN
fnp-4366	654	24	,	,	PUNCT
fnp-4366	654	25	30	30	NUM
fnp-4366	654	26	-	-	SYM
fnp-4366	654	27	300	300	NUM
fnp-4366	654	28	µ	µ	NOUN
fnp-4366	654	29	i	i	NOUN
fnp-4366	654	30	m	m	VERB
fnp-4366	654	31	durchmesser	durchmesser	ADJ
fnp-4366	654	32	,	,	PUNCT
fnp-4366	654	33	meist	meist	PROPN
fnp-4366	654	34	glatt	glatt	PROPN
fnp-4366	654	35	begrenzt	begrenzt	PROPN
fnp-4366	654	36	und	und	VERB
fnp-4366	654	37	ohne	ohne	NOUN
fnp-4366	654	38	zellbelag	zellbelag	NOUN
fnp-4366	654	39	.	.	PUNCT
fnp-4366	655	1	bei	bei	NOUN
fnp-4366	655	2	immunhistochemischen	immunhistochemischen	ADV
fnp-4366	655	3	untersuchungen	untersuchungen	PROPN
fnp-4366	655	4	in	in	ADP
fnp-4366	655	5	ausgewählten	ausgewählten	PROPN
fnp-4366	655	6	fällen	fällen	PROPN
fnp-4366	655	7	zeigten	zeigten	PROPN
fnp-4366	655	8	sie	sie	PROPN
fnp-4366	655	9	keine	keine	VERB
fnp-4366	655	10	positive	positive	ADJ
fnp-4366	655	11	reaktion	reaktion	NOUN
fnp-4366	655	12	auf	auf	PROPN
fnp-4366	655	13	podoplanin	podoplanin	PROPN
fnp-4366	655	14	,	,	PUNCT
fnp-4366	655	15	cd31	cd31	PROPN
fnp-4366	655	16	,	,	PUNCT
fnp-4366	655	17	cd34	cd34	PROPN
fnp-4366	655	18	,	,	PUNCT
fnp-4366	655	19	s100	s100	PROPN
fnp-4366	655	20	,	,	PUNCT
fnp-4366	655	21	aβ	aβ	PRON
fnp-4366	655	22	und	und	VERB
fnp-4366	655	23	app	app	PROPN
fnp-4366	655	24	.	.	PUNCT
fnp-4366	656	1	dagegen	dagegen	PROPN
fnp-4366	656	2	ließen	ließen	PROPN
fnp-4366	656	3	sich	sich	PROPN
fnp-4366	656	4	lymphgefäße	lymphgefäße	VERB
fnp-4366	656	5	deutlich	deutlich	NOUN
fnp-4366	656	6	anhand	anhand	PROPN
fnp-4366	656	7	ihrer	ihrer	X
fnp-4366	656	8	positiven	positiven	PROPN
fnp-4366	656	9	reaktion	reaktion	PROPN
fnp-4366	656	10	auf	auf	PROPN
fnp-4366	656	11	podoplanin	podoplanin	PROPN
fnp-4366	656	12	identifizieren	identifizieren	PROPN
fnp-4366	656	13	,	,	PUNCT
fnp-4366	656	14	sie	sie	PROPN
fnp-4366	656	15	erschienen	erschienen	PROPN
fnp-4366	656	16	durchweg	durchweg	ADJ
fnp-4366	656	17	streifenförmig	streifenförmig	NOUN
fnp-4366	656	18	-	-	PUNCT
fnp-4366	656	19	schmal	schmal	ADJ
fnp-4366	656	20	und	und	NOUN
fnp-4366	656	21	regelrecht	regelrecht	NOUN
fnp-4366	656	22	strukturiert	strukturiert	PROPN
fnp-4366	656	23	.	.	PUNCT
fnp-4366	657	1	die	die	PROPN
fnp-4366	657	2	anzahl	anzahl	PROPN
fnp-4366	657	3	der	der	PROPN
fnp-4366	657	4	vakuolen	vakuolen	NOUN
fnp-4366	657	5	-	-	PUNCT
fnp-4366	657	6	gruppen	gruppen	NOUN
fnp-4366	657	7	und	und	NOUN
fnp-4366	657	8	ihre	ihre	NOUN
fnp-4366	657	9	dichte	dichte	NOUN
fnp-4366	657	10	in	in	ADP
fnp-4366	657	11	der	der	ADJ
fnp-4366	657	12	dura	dura	PROPN
fnp-4366	657	13	wurde	wurde	PROPN
fnp-4366	657	14	semiquantitativ	semiquantitativ	PROPN
fnp-4366	657	15	in	in	ADP
fnp-4366	657	16	6	6	NUM
fnp-4366	657	17	stufen	stufen	ADJ
fnp-4366	657	18	von	von	PROPN
fnp-4366	657	19	nicht	nicht	PROPN
fnp-4366	657	20	vorhanden	vorhanden	PROPN
fnp-4366	657	21	bis	bis	PROPN
fnp-4366	657	22	stark	stark	ADJ
fnp-4366	657	23	eingeteilt	eingeteilt	NOUN
fnp-4366	657	24	,	,	PUNCT
fnp-4366	657	25	und	und	VERB
fnp-4366	657	26	diese	diese	ADJ
fnp-4366	657	27	stufen	stufen	VERB
fnp-4366	657	28	wurden	wurden	ADJ
fnp-4366	657	29	jeweils	jeweils	PROPN
fnp-4366	657	30	den	den	VERB
fnp-4366	657	31	falldaten	falldaten	ADJ
fnp-4366	657	32	gegenübergestellt	gegenübergestellt	PROPN
fnp-4366	657	33	.	.	PUNCT
fnp-4366	658	1	eine	eine	PROPN
fnp-4366	658	2	korrelation	korrelation	PROPN
fnp-4366	658	3	mit	mit	PROPN
fnp-4366	658	4	bestimmten	bestimmten	PROPN
fnp-4366	658	5	erkrankungen	erkrankungen	PROPN
fnp-4366	658	6	ergab	ergab	PROPN
fnp-4366	658	7	sich	sich	PROPN
fnp-4366	658	8	nicht	nicht	PROPN
fnp-4366	658	9	,	,	PUNCT
fnp-4366	658	10	lediglich	lediglich	PROPN
fnp-4366	658	11	eine	eine	PROPN
fnp-4366	658	12	partielle	partielle	PROPN
fnp-4366	658	13	korrelation	korrelation	PROPN
fnp-4366	658	14	mit	mit	VERB
fnp-4366	658	15	dem	dem	PROPN
fnp-4366	658	16	alter	alter	PROPN
fnp-4366	658	17	.	.	PUNCT
fnp-4366	659	1	deutlich	deutlich	PROPN
fnp-4366	659	2	vermehrt	vermehrt	PROPN
fnp-4366	659	3	waren	waren	PROPN
fnp-4366	659	4	vakuolen	vakuolen	VERB
fnp-4366	659	5	bei	bei	PROPN
fnp-4366	659	6	gleichzeitigem	gleichzeitigem	PROPN
fnp-4366	659	7	nachweis	nachweis	VERB
fnp-4366	659	8	einer	einer	PROPN
fnp-4366	659	9	größeren	größeren	PROPN
fnp-4366	659	10	anzahl	anzahl	PROPN
fnp-4366	659	11	fibrosierter	fibrosierter	PROPN
fnp-4366	659	12	pacchionischer	pacchionischer	PROPN
fnp-4366	659	13	granulationen	granulationen	NOUN
fnp-4366	659	14	vorhanden	vorhanden	PROPN
fnp-4366	659	15	.	.	PUNCT
fnp-4366	660	1	zusammenfassend	zusammenfassend	PROPN
fnp-4366	660	2	stellt	stellt	PROPN
fnp-4366	660	3	eine	eine	PROPN
fnp-4366	660	4	vakuolisierung	vakuolisierung	PROPN
fnp-4366	660	5	der	der	PROPN
fnp-4366	660	6	dura	dura	PROPN
fnp-4366	660	7	i	i	PROPN
fnp-4366	660	8	m	m	VERB
fnp-4366	660	9	sinusdach	sinusdach	NOUN
fnp-4366	660	10	-	-	PUNCT
fnp-4366	660	11	bereich	bereich	NOUN
fnp-4366	660	12	eine	eine	PROPN
fnp-4366	660	13	relativ	relativ	PROPN
fnp-4366	660	14	häufige	häufige	PROPN
fnp-4366	660	15	veränderung	veränderung	PROPN
fnp-4366	660	16	dar	dar	PROPN
fnp-4366	660	17	,	,	PUNCT
fnp-4366	660	18	nicht	nicht	NOUN
fnp-4366	660	19	i	i	PRON
fnp-4366	660	20	m	m	VERB
fnp-4366	660	21	zusammenhang	zusammenhang	NOUN
fnp-4366	660	22	mit	mit	PROPN
fnp-4366	660	23	dem	dem	PROPN
fnp-4366	660	24	lymphsystem	lymphsystem	PROPN
fnp-4366	660	25	stehend	stehend	VERB
fnp-4366	660	26	sowie	sowie	ADJ
fnp-4366	660	27	offenbar	offenbar	ADJ
fnp-4366	660	28	nicht	nicht	NOUN
fnp-4366	660	29	krankheits	krankheit	NOUN
fnp-4366	660	30	-	-	PUNCT
fnp-4366	660	31	korreliert	korreliert	NOUN
fnp-4366	660	32	und	und	NOUN
fnp-4366	660	33	am	be	AUX
fnp-4366	660	34	ehesten	ehesten	VERB
fnp-4366	660	35	degenerativer	degenerativer	PROPN
fnp-4366	660	36	natur	natur	PROPN
fnp-4366	660	37	.	.	PUNCT
fnp-4366	661	1	die	die	PROPN
fnp-4366	661	2	befunde	befunde	PROPN
fnp-4366	661	3	bestätigen	bestätigen	PROPN
fnp-4366	661	4	und	und	PROPN
fnp-4366	661	5	ergänzen	ergänzen	NOUN
fnp-4366	661	6	kurze	kurze	PROPN
fnp-4366	661	7	angaben	angaben	PROPN
fnp-4366	661	8	der	der	PROPN
fnp-4366	661	9	älteren	älteren	PROPN
fnp-4366	661	10	literatur	literatur	PROPN
fnp-4366	661	11	,	,	PUNCT
fnp-4366	661	12	wo	will	AUX
fnp-4366	661	13	zunächst	zunächst	PROPN
fnp-4366	661	14	von	von	PROPN
fnp-4366	661	15	grüppchen	grüppchen	PROPN
fnp-4366	661	16	großblasiger	großblasiger	PROPN
fnp-4366	661	17	zellen	zellen	PROPN
fnp-4366	661	18	gesprochen	gesprochen	PROPN
fnp-4366	661	19	wird	wird	PROPN
fnp-4366	661	20	(	(	PUNCT
fnp-4366	661	21	schaffer	schaffer	PROPN
fnp-4366	661	22	j	j	PROPN
fnp-4366	661	23	1933	1933	NUM
fnp-4366	661	24	)	)	PUNCT
fnp-4366	661	25	,	,	PUNCT
fnp-4366	661	26	dann	dann	PROPN
fnp-4366	661	27	aber	aber	PROPN
fnp-4366	661	28	von	von	PROPN
fnp-4366	661	29	altersveränderungen	altersveränderungen	PROPN
fnp-4366	661	30	mit	mit	PROPN
fnp-4366	661	31	hohlraumbildungen	hohlraumbildungen	PROPN
fnp-4366	661	32	durch	durch	NOUN
fnp-4366	661	33	aufquellung	aufquellung	PROPN
fnp-4366	661	34	und	und	VERB
fnp-4366	661	35	zerfall	zerfall	PROPN
fnp-4366	661	36	von	von	PROPN
fnp-4366	661	37	bindegewebsfasern	bindegewebsfasern	PROPN
fnp-4366	661	38	(	(	PUNCT
fnp-4366	661	39	schaltenbrand	schaltenbrand	NOUN
fnp-4366	661	40	g	g	PROPN
fnp-4366	661	41	u.	u.	PROPN
fnp-4366	661	42	dorn	dorn	PROPN
fnp-4366	661	43	e	e	PROPN
fnp-4366	661	44	1955	1955	NUM
fnp-4366	661	45	)	)	PUNCT
fnp-4366	661	46	.	.	PUNCT
fnp-4366	661	47	  	  	SPACE
fnp-4366	662	1	6.04	6.04	NUM
fnp-4366	662	2	free	free	ADJ
fnp-4366	662	3	neuropathol	neuropathol	NOUN
fnp-4366	662	4	3:20:64	3:20:64	NUM
fnp-4366	662	5	moghe	moghe	VERB
fnp-4366	662	6	with	with	ADP
fnp-4366	662	7	or	or	CCONJ
fnp-4366	662	8	without	without	ADP
fnp-4366	662	9	slc35a2	slc35a2	NOUN
fnp-4366	662	10	brain	brain	NOUN
fnp-4366	662	11	somatic	somatic	ADJ
fnp-4366	662	12	mutations	mutation	NOUN
fnp-4366	662	13	reveal	reveal	VERB
fnp-4366	662	14	a	a	DET
fnp-4366	662	15	common	common	ADJ
fnp-4366	662	16	phenotype	phenotype	NOUN
fnp-4366	662	17	of	of	ADP
fnp-4366	662	18	oligodendroglial	oligodendroglial	ADJ
fnp-4366	662	19	regeneration	regeneration	NOUN
fnp-4366	662	20	and	and	CCONJ
fnp-4366	662	21	remyelination	remyelination	NOUN
fnp-4366	662	22	simon	simon	PROPN
fnp-4366	662	23	geffers1	geffers1	PROPN
fnp-4366	662	24	,	,	PUNCT
fnp-4366	662	25	lucas	lucas	PROPN
fnp-4366	662	26	hoffmann1	hoffmann1	PROPN
fnp-4366	662	27	,	,	PUNCT
fnp-4366	662	28	roland	roland	PROPN
fnp-4366	662	29	coras1	coras1	PROPN
fnp-4366	662	30	,	,	PUNCT
fnp-4366	662	31	katja	katja	PROPN
fnp-4366	662	32	kobow1	kobow1	PROPN
fnp-4366	662	33	,	,	PUNCT
fnp-4366	662	34	javier	javier	PROPN
fnp-4366	662	35	lopez	lopez	PROPN
fnp-4366	662	36	-	-	PUNCT
fnp-4366	662	37	riviera2,3,4	riviera2,3,4	NOUN
fnp-4366	662	38	,	,	PUNCT
fnp-4366	662	39	costin	costin	PROPN
fnp-4366	662	40	leu3,4,5,6	leu3,4,5,6	PROPN
fnp-4366	662	41	,	,	PUNCT
fnp-4366	662	42	dennis	dennis	PROPN
fnp-4366	662	43	lal3,4,5,6	lal3,4,5,6	PROPN
fnp-4366	662	44	,	,	PUNCT
fnp-4366	662	45	peter	peter	PROPN
fnp-4366	662	46	nürnberg6	nürnberg6	PROPN
fnp-4366	662	47	,	,	PUNCT
fnp-4366	662	48	stephanie	stephanie	PROPN
fnp-4366	662	49	bulac7	bulac7	PROPN
fnp-4366	662	50	,	,	PUNCT
fnp-4366	662	51	till	till	SCONJ
fnp-4366	662	52	hartlieb8,9	hartlieb8,9	PROPN
fnp-4366	662	53	,	,	PUNCT
fnp-4366	662	54	tom	tom	PROPN
fnp-4366	662	55	pieper8	pieper8	PROPN
fnp-4366	662	56	,	,	PUNCT
fnp-4366	662	57	manfred	manfre	VERB
fnp-4366	662	58	kudernatsch8,10	kudernatsch8,10	PROPN
fnp-4366	662	59	,	,	PUNCT
fnp-4366	662	60	christian	christian	ADJ
fnp-4366	662	61	bien11	bien11	NOUN
fnp-4366	662	62	,	,	PUNCT
fnp-4366	662	63	hajo	hajo	ADJ
fnp-4366	662	64	hamer12	hamer12	NOUN
fnp-4366	662	65	,	,	PUNCT
fnp-4366	662	66	karl	karl	PROPN
fnp-4366	662	67	rössler13,14	rössler13,14	PROPN
fnp-4366	662	68	,	,	PUNCT
fnp-4366	662	69	sebastian	sebastian	PROPN
fnp-4366	662	70	brandtner14	brandtner14	PROPN
fnp-4366	662	71	,	,	PUNCT
fnp-4366	662	72	christine	christine	PROPN
fnp-4366	662	73	stadelmann15	stadelmann15	PROPN
fnp-4366	662	74	,	,	PUNCT
fnp-4366	662	75	ingmar	ingmar	PROPN
fnp-4366	662	76	blümcke1	blümcke1	PROPN
fnp-4366	662	77	1	1	NUM
fnp-4366	662	78	department	department	NOUN
fnp-4366	662	79	of	of	ADP
fnp-4366	662	80	neuropathology	neuropathology	NOUN
fnp-4366	662	81	,	,	PUNCT
fnp-4366	662	82	university	university	NOUN
fnp-4366	662	83	hospital	hospital	NOUN
fnp-4366	662	84	erlangen	erlangen	PROPN
fnp-4366	662	85	,	,	PUNCT
fnp-4366	662	86	erlangen	erlangen	PROPN
fnp-4366	662	87	,	,	PUNCT
fnp-4366	662	88	deutschland	deutschland	PROPN
fnp-4366	662	89	2	2	NUM
fnp-4366	662	90	department	department	NOUN
fnp-4366	662	91	of	of	ADP
fnp-4366	662	92	molecular	molecular	ADJ
fnp-4366	662	93	medicine	medicine	NOUN
fnp-4366	662	94	,	,	PUNCT
fnp-4366	662	95	cleveland	cleveland	PROPN
fnp-4366	662	96	clinic	clinic	PROPN
fnp-4366	662	97	lerner	lerner	PROPN
fnp-4366	662	98	college	college	PROPN
fnp-4366	662	99	of	of	ADP
fnp-4366	662	100	medicine	medicine	NOUN
fnp-4366	662	101	,	,	PUNCT
fnp-4366	662	102	cleveland	cleveland	PROPN
fnp-4366	662	103	,	,	PUNCT
fnp-4366	662	104	united	united	PROPN
fnp-4366	662	105	states	states	PROPN
fnp-4366	662	106	3	3	NUM
fnp-4366	662	107	genomic	genomic	PROPN
fnp-4366	662	108	medicine	medicine	PROPN
fnp-4366	662	109	institute	institute	PROPN
fnp-4366	662	110	,	,	PUNCT
fnp-4366	662	111	lerner	lerner	PROPN
fnp-4366	662	112	research	research	PROPN
fnp-4366	662	113	center	center	PROPN
fnp-4366	662	114	,	,	PUNCT
fnp-4366	662	115	cleveland	cleveland	PROPN
fnp-4366	662	116	clinic	clinic	PROPN
fnp-4366	662	117	,	,	PUNCT
fnp-4366	662	118	cleveland	cleveland	PROPN
fnp-4366	662	119	,	,	PUNCT
fnp-4366	662	120	united	united	PROPN
fnp-4366	662	121	states	states	PROPN
fnp-4366	662	122	4	4	NUM
fnp-4366	662	123	charles	charles	PROPN
fnp-4366	662	124	shor	shor	PROPN
fnp-4366	662	125	epilepsy	epilepsy	PROPN
fnp-4366	662	126	center	center	NOUN
fnp-4366	662	127	,	,	PUNCT
fnp-4366	662	128	neurological	neurological	ADJ
fnp-4366	662	129	institute	institute	NOUN
fnp-4366	662	130	,	,	PUNCT
fnp-4366	662	131	cleveland	cleveland	PROPN
fnp-4366	662	132	clinic	clinic	PROPN
fnp-4366	662	133	,	,	PUNCT
fnp-4366	662	134	cleveland	cleveland	PROPN
fnp-4366	662	135	,	,	PUNCT
fnp-4366	662	136	united	united	PROPN
fnp-4366	662	137	states	states	PROPN
fnp-4366	662	138	5	5	NUM
fnp-4366	662	139	stanley	stanley	PROPN
fnp-4366	662	140	center	center	PROPN
fnp-4366	662	141	for	for	ADP
fnp-4366	662	142	psychiatric	psychiatric	ADJ
fnp-4366	662	143	research	research	NOUN
fnp-4366	662	144	,	,	PUNCT
fnp-4366	662	145	broad	broad	PROPN
fnp-4366	662	146	institute	institute	PROPN
fnp-4366	662	147	of	of	ADP
fnp-4366	662	148	harvard	harvard	PROPN
fnp-4366	662	149	and	and	CCONJ
fnp-4366	662	150	m.i.t	m.i.t	PROPN
fnp-4366	662	151	,	,	PUNCT
fnp-4366	662	152	cambridge	cambridge	PROPN
fnp-4366	662	153	,	,	PUNCT
fnp-4366	662	154	united	united	PROPN
fnp-4366	662	155	states	states	PROPN
fnp-4366	662	156	6	6	NUM
fnp-4366	662	157	cologne	cologne	NOUN
fnp-4366	662	158	center	center	NOUN
fnp-4366	662	159	for	for	ADP
fnp-4366	662	160	genomics	genomics	NOUN
fnp-4366	662	161	(	(	PUNCT
fnp-4366	662	162	ccg	ccg	NOUN
fnp-4366	662	163	)	)	PUNCT
fnp-4366	662	164	,	,	PUNCT
fnp-4366	662	165	medical	medical	ADJ
fnp-4366	662	166	faculty	faculty	NOUN
fnp-4366	662	167	of	of	ADP
fnp-4366	662	168	the	the	DET
fnp-4366	662	169	university	university	NOUN
fnp-4366	662	170	of	of	ADP
fnp-4366	662	171	cologne	cologne	NOUN
fnp-4366	662	172	,	,	PUNCT
fnp-4366	662	173	university	university	NOUN
fnp-4366	662	174	hospital	hospital	NOUN
fnp-4366	662	175	of	of	ADP
fnp-4366	662	176	cologne	cologne	NOUN
fnp-4366	662	177	,	,	PUNCT
fnp-4366	662	178	cologne	cologne	NOUN
fnp-4366	662	179	,	,	PUNCT
fnp-4366	662	180	deutschland	deutschland	NOUN
fnp-4366	662	181	7	7	NUM
fnp-4366	662	182	sorbonne	sorbonne	PROPN
fnp-4366	662	183	université	université	PROPN
fnp-4366	662	184	,	,	PUNCT
fnp-4366	662	185	institut	institut	PROPN
fnp-4366	662	186	du	du	PROPN
fnp-4366	662	187	cerveau	cerveau	PROPN
fnp-4366	662	188	,	,	PUNCT
fnp-4366	662	189	paris	paris	PROPN
fnp-4366	662	190	brain	brain	PROPN
fnp-4366	662	191	institute	institute	PROPN
fnp-4366	662	192	,	,	PUNCT
fnp-4366	662	193	paris	paris	PROPN
fnp-4366	662	194	,	,	PUNCT
fnp-4366	662	195	france	france	PROPN
fnp-4366	662	196	8	8	NUM
fnp-4366	662	197	center	center	NOUN
fnp-4366	662	198	for	for	ADP
fnp-4366	662	199	pediatric	pediatric	ADJ
fnp-4366	662	200	neurology	neurology	NOUN
fnp-4366	662	201	,	,	PUNCT
fnp-4366	662	202	neurorehabilitation	neurorehabilitation	NOUN
fnp-4366	662	203	and	and	CCONJ
fnp-4366	662	204	epileptology	epileptology	NOUN
fnp-4366	662	205	,	,	PUNCT
fnp-4366	662	206	schoen	schoen	PROPN
fnp-4366	662	207	klinik	klinik	PROPN
fnp-4366	662	208	vogtareuth	vogtareuth	PROPN
fnp-4366	662	209	,	,	PUNCT
fnp-4366	662	210	vogtareuth	vogtareuth	ADV
fnp-4366	662	211	,	,	PUNCT
fnp-4366	662	212	deutschland	deutschland	NOUN
fnp-4366	662	213	9	9	NUM
fnp-4366	662	214	research	research	NOUN
fnp-4366	662	215	institute	institute	NOUN
fnp-4366	662	216	rehabilitation	rehabilitation	NOUN
fnp-4366	662	217	,	,	PUNCT
fnp-4366	662	218	transition	transition	NOUN
fnp-4366	662	219	,	,	PUNCT
fnp-4366	662	220	palliation	palliation	NOUN
fnp-4366	662	221	,	,	PUNCT
fnp-4366	662	222	pmu	pmu	PROPN
fnp-4366	662	223	salzburg	salzburg	PROPN
fnp-4366	662	224	,	,	PUNCT
fnp-4366	662	225	salzburg	salzburg	PROPN
fnp-4366	662	226	,	,	PUNCT
fnp-4366	662	227	austria	austria	PROPN
fnp-4366	662	228	10	10	NUM
fnp-4366	662	229	center	center	NOUN
fnp-4366	662	230	for	for	ADP
fnp-4366	662	231	neurosurgery	neurosurgery	NOUN
fnp-4366	662	232	,	,	PUNCT
fnp-4366	662	233	epilepsy	epilepsy	ADJ
fnp-4366	662	234	surgery	surgery	NOUN
fnp-4366	662	235	,	,	PUNCT
fnp-4366	662	236	spine	spine	ADJ
fnp-4366	662	237	surgery	surgery	NOUN
fnp-4366	662	238	and	and	CCONJ
fnp-4366	662	239	scoliosis	scoliosis	NOUN
fnp-4366	662	240	,	,	PUNCT
fnp-4366	662	241	schoen	schoen	X
fnp-4366	662	242	klinik	klinik	PROPN
fnp-4366	662	243	vogtareuth	vogtareuth	PROPN
fnp-4366	662	244	,	,	PUNCT
fnp-4366	662	245	vogtareuth	vogtareuth	ADV
fnp-4366	662	246	,	,	PUNCT
fnp-4366	662	247	deutschland	deutschland	NOUN
fnp-4366	662	248	11	11	NUM
fnp-4366	662	249	department	department	NOUN
fnp-4366	662	250	of	of	ADP
fnp-4366	662	251	epileptology	epileptology	NOUN
fnp-4366	662	252	(	(	PUNCT
fnp-4366	662	253	krankenhaus	krankenhaus	PROPN
fnp-4366	662	254	mara	mara	PROPN
fnp-4366	662	255	)	)	PUNCT
fnp-4366	662	256	,	,	PUNCT
fnp-4366	662	257	bielefeld	bielefeld	PROPN
fnp-4366	662	258	university	university	PROPN
fnp-4366	662	259	,	,	PUNCT
fnp-4366	662	260	bielefeld	bielefeld	PROPN
fnp-4366	662	261	,	,	PUNCT
fnp-4366	662	262	deutschland	deutschland	NOUN
fnp-4366	662	263	12	12	NUM
fnp-4366	662	264	epilepsy	epilepsy	NOUN
fnp-4366	662	265	center	center	NOUN
fnp-4366	662	266	,	,	PUNCT
fnp-4366	662	267	university	university	NOUN
fnp-4366	662	268	hospital	hospital	NOUN
fnp-4366	662	269	erlangen	erlangen	PROPN
fnp-4366	662	270	,	,	PUNCT
fnp-4366	662	271	fau	fau	PROPN
fnp-4366	662	272	erlangen	erlangen	PROPN
fnp-4366	662	273	nürnberg	nürnberg	PROPN
fnp-4366	662	274	,	,	PUNCT
fnp-4366	662	275	erlangen	erlangen	PROPN
fnp-4366	662	276	,	,	PUNCT
fnp-4366	662	277	deutschland	deutschland	PROPN
fnp-4366	662	278	13	13	NUM
fnp-4366	662	279	department	department	NOUN
fnp-4366	662	280	of	of	ADP
fnp-4366	662	281	neurosurgery	neurosurgery	NOUN
fnp-4366	662	282	,	,	PUNCT
fnp-4366	662	283	university	university	NOUN
fnp-4366	662	284	hospital	hospital	NOUN
fnp-4366	662	285	erlangen	erlangen	PROPN
fnp-4366	662	286	,	,	PUNCT
fnp-4366	662	287	fau	fau	PROPN
fnp-4366	662	288	erlangen	erlangen	PROPN
fnp-4366	662	289	nürnberg	nürnberg	PROPN
fnp-4366	662	290	,	,	PUNCT
fnp-4366	662	291	erlangen	erlangen	PROPN
fnp-4366	662	292	,	,	PUNCT
fnp-4366	662	293	deutschland	deutschland	PROPN
fnp-4366	662	294	14	14	NUM
fnp-4366	662	295	department	department	NOUN
fnp-4366	662	296	of	of	ADP
fnp-4366	662	297	neurosurgery	neurosurgery	NOUN
fnp-4366	662	298	,	,	PUNCT
fnp-4366	662	299	medical	medical	ADJ
fnp-4366	662	300	university	university	PROPN
fnp-4366	662	301	of	of	ADP
fnp-4366	662	302	vienna	vienna	PROPN
fnp-4366	662	303	,	,	PUNCT
fnp-4366	662	304	vienna	vienna	PROPN
fnp-4366	662	305	general	general	PROPN
fnp-4366	662	306	hospital	hospital	PROPN
fnp-4366	662	307	,	,	PUNCT
fnp-4366	662	308	vienna	vienna	PROPN
fnp-4366	662	309	,	,	PUNCT
fnp-4366	662	310	austria	austria	PROPN
fnp-4366	662	311	15	15	NUM
fnp-4366	662	312	institute	institute	PROPN
fnp-4366	662	313	of	of	ADP
fnp-4366	662	314	neuropathology	neuropathology	NOUN
fnp-4366	662	315	,	,	PUNCT
fnp-4366	662	316	university	university	NOUN
fnp-4366	662	317	medical	medical	ADJ
fnp-4366	662	318	center	center	NOUN
fnp-4366	662	319	göttingen	göttingen	NOUN
fnp-4366	662	320	,	,	PUNCT
fnp-4366	662	321	göttingen	göttingen	NOUN
fnp-4366	662	322	,	,	PUNCT
fnp-4366	662	323	deutschland	deutschland	NOUN
fnp-4366	662	324	mild	mild	ADJ
fnp-4366	662	325	malformation	malformation	NOUN
fnp-4366	662	326	of	of	ADP
fnp-4366	662	327	cortical	cortical	ADJ
fnp-4366	662	328	development	development	NOUN
fnp-4366	662	329	with	with	ADP
fnp-4366	662	330	oligodendroglial	oligodendroglial	ADJ
fnp-4366	662	331	hyperplasia	hyperplasia	NOUN
fnp-4366	662	332	in	in	ADP
fnp-4366	662	333	epilepsy	epilepsy	NOUN
fnp-4366	662	334	(	(	PUNCT
fnp-4366	662	335	moghe	moghe	NOUN
fnp-4366	662	336	)	)	PUNCT
fnp-4366	662	337	is	be	AUX
fnp-4366	662	338	a	a	DET
fnp-4366	662	339	recently	recently	ADV
fnp-4366	662	340	identified	identify	VERB
fnp-4366	662	341	disease	disease	NOUN
fnp-4366	662	342	entity	entity	NOUN
fnp-4366	662	343	associated	associate	VERB
fnp-4366	662	344	with	with	ADP
fnp-4366	662	345	early	early	ADJ
fnp-4366	662	346	onset	onset	VERB
fnp-4366	662	347	frontal	frontal	ADJ
fnp-4366	662	348	lobe	lobe	NOUN
fnp-4366	662	349	epilepsy	epilepsy	NOUN
fnp-4366	662	350	in	in	ADP
fnp-4366	662	351	the	the	DET
fnp-4366	662	352	vast	vast	ADJ
fnp-4366	662	353	majority	majority	NOUN
fnp-4366	662	354	of	of	ADP
fnp-4366	662	355	reported	report	VERB
fnp-4366	662	356	cases	case	NOUN
fnp-4366	662	357	.	.	PUNCT
fnp-4366	663	1	brain	brain	NOUN
fnp-4366	663	2	somatic	somatic	ADJ
fnp-4366	663	3	mutations	mutation	NOUN
fnp-4366	663	4	in	in	ADP
fnp-4366	663	5	the	the	DET
fnp-4366	663	6	udp	udp	NOUN
fnp-4366	663	7	-	-	NOUN
fnp-4366	663	8	galactose	galactose	ADJ
fnp-4366	663	9	transporter	transporter	NOUN
fnp-4366	663	10	slc35a2	slc35a2	NOUN
fnp-4366	663	11	gene	gene	NOUN
fnp-4366	663	12	were	be	AUX
fnp-4366	663	13	identified	identify	VERB
fnp-4366	663	14	in	in	ADP
fnp-4366	663	15	about	about	ADV
fnp-4366	663	16	50	50	NUM
fnp-4366	663	17	%	%	NOUN
fnp-4366	663	18	of	of	ADP
fnp-4366	663	19	published	publish	VERB
fnp-4366	663	20	moghe	moghe	NOUN
fnp-4366	663	21	cases	case	NOUN
fnp-4366	663	22	as	as	ADP
fnp-4366	663	23	underlying	underlying	ADJ
fnp-4366	663	24	pathogenetic	pathogenetic	ADJ
fnp-4366	663	25	variant	variant	NOUN
fnp-4366	663	26	.	.	PUNCT
fnp-4366	664	1	herein	herein	NOUN
fnp-4366	664	2	,	,	PUNCT
fnp-4366	664	3	we	we	PRON
fnp-4366	664	4	performed	perform	VERB
fnp-4366	664	5	a	a	DET
fnp-4366	664	6	phenotype	phenotype	NOUN
fnp-4366	664	7	-	-	PUNCT
fnp-4366	664	8	genotype	genotype	NOUN
fnp-4366	664	9	analysis	analysis	NOUN
fnp-4366	664	10	of	of	ADP
fnp-4366	664	11	moghe	moghe	NOUN
fnp-4366	664	12	with	with	ADP
fnp-4366	664	13	slc35a2	slc35a2	NOUN
fnp-4366	664	14	mutations	mutation	NOUN
fnp-4366	664	15	compared	compare	VERB
fnp-4366	664	16	to	to	PART
fnp-4366	664	17	moghe	moghe	VERB
fnp-4366	664	18	without	without	ADP
fnp-4366	664	19	slc25a2	slc25a2	NOUN
fnp-4366	664	20	mutations	mutation	NOUN
fnp-4366	664	21	in	in	ADP
fnp-4366	664	22	order	order	NOUN
fnp-4366	664	23	to	to	PART
fnp-4366	664	24	assess	assess	VERB
fnp-4366	664	25	a	a	DET
fnp-4366	664	26	potentially	potentially	ADV
fnp-4366	664	27	different	different	ADJ
fnp-4366	664	28	phenotype	phenotype	NOUN
fnp-4366	664	29	-	-	PUNCT
fnp-4366	664	30	genotype	genotype	NOUN
fnp-4366	664	31	relationship	relationship	NOUN
fnp-4366	664	32	at	at	ADP
fnp-4366	664	33	the	the	DET
fnp-4366	664	34	microscopy	microscopy	NOUN
fnp-4366	664	35	and	and	CCONJ
fnp-4366	664	36	clinical	clinical	ADJ
fnp-4366	664	37	level	level	NOUN
fnp-4366	664	38	.	.	PUNCT
fnp-4366	665	1	this	this	PRON
fnp-4366	665	2	may	may	AUX
fnp-4366	665	3	also	also	ADV
fnp-4366	665	4	help	help	VERB
fnp-4366	665	5	us	we	PRON
fnp-4366	665	6	to	to	PART
fnp-4366	665	7	further	far	ADV
fnp-4366	665	8	untangle	untangle	VERB
fnp-4366	665	9	the	the	DET
fnp-4366	665	10	yet	yet	ADV
fnp-4366	665	11	unknown	unknown	ADJ
fnp-4366	665	12	aetiological	aetiological	ADJ
fnp-4366	665	13	spectrum	spectrum	NOUN
fnp-4366	665	14	of	of	ADP
fnp-4366	665	15	the	the	DET
fnp-4366	665	16	moghe	moghe	ADJ
fnp-4366	665	17	disease	disease	NOUN
fnp-4366	665	18	.	.	PUNCT
fnp-4366	666	1	we	we	PRON
fnp-4366	666	2	retrieved	retrieve	VERB
fnp-4366	666	3	39	39	NUM
fnp-4366	666	4	surgical	surgical	ADJ
fnp-4366	666	5	brain	brain	NOUN
fnp-4366	666	6	specimens	specimen	NOUN
fnp-4366	666	7	histopathologically	histopathologically	ADV
fnp-4366	666	8	characterized	characterize	VERB
fnp-4366	666	9	as	as	ADP
fnp-4366	666	10	moghe	moghe	NOUN
fnp-4366	666	11	from	from	ADP
fnp-4366	666	12	the	the	DET
fnp-4366	666	13	archives	archive	NOUN
fnp-4366	666	14	of	of	ADP
fnp-4366	666	15	the	the	DET
fnp-4366	666	16	european	european	ADJ
fnp-4366	666	17	epilepsy	epilepsy	PROPN
fnp-4366	666	18	brain	brain	PROPN
fnp-4366	666	19	bank	bank	PROPN
fnp-4366	666	20	,	,	PUNCT
fnp-4366	666	21	19	19	NUM
fnp-4366	666	22	with	with	ADP
fnp-4366	666	23	and	and	CCONJ
fnp-4366	666	24	20	20	NUM
fnp-4366	666	25	without	without	ADP
fnp-4366	666	26	brain	brain	NOUN
fnp-4366	666	27	somatic	somatic	ADJ
fnp-4366	666	28	slc35a2	slc35a2	NOUN
fnp-4366	666	29	variants	variant	NOUN
fnp-4366	666	30	and	and	CCONJ
fnp-4366	666	31	compared	compare	VERB
fnp-4366	666	32	them	they	PRON
fnp-4366	666	33	with	with	ADP
fnp-4366	666	34	20	20	NUM
fnp-4366	666	35	age	age	NOUN
fnp-4366	666	36	-	-	PUNCT
fnp-4366	666	37	matched	match	VERB
fnp-4366	666	38	controls	control	NOUN
fnp-4366	666	39	,	,	PUNCT
fnp-4366	666	40	i.e.	i.e.	X
fnp-4366	666	41	,	,	PUNCT
fnp-4366	666	42	fcd	fcd	ADJ
fnp-4366	666	43	2a	2a	NUM
fnp-4366	666	44	(	(	PUNCT
fnp-4366	666	45	n=10	n=10	NOUN
fnp-4366	666	46	)	)	PUNCT
fnp-4366	666	47	and	and	CCONJ
fnp-4366	666	48	non	non	ADJ
fnp-4366	666	49	-	-	ADJ
fnp-4366	666	50	epileptic	epileptic	ADJ
fnp-4366	666	51	post	post	ADJ
fnp-4366	666	52	-	-	ADJ
fnp-4366	666	53	mortem	mortem	ADJ
fnp-4366	666	54	specimens	specimen	NOUN
fnp-4366	666	55	of	of	ADP
fnp-4366	666	56	the	the	DET
fnp-4366	666	57	frontal	frontal	ADJ
fnp-4366	666	58	neocortex	neocortex	NOUN
fnp-4366	666	59	(	(	PUNCT
fnp-4366	666	60	n=10	n=10	NOUN
fnp-4366	666	61	)	)	PUNCT
fnp-4366	666	62	.	.	PUNCT
fnp-4366	667	1	semi	semi	ADJ
fnp-4366	667	2	-	-	ADJ
fnp-4366	667	3	quantitative	quantitative	ADJ
fnp-4366	667	4	analysis	analysis	NOUN
fnp-4366	667	5	using	use	VERB
fnp-4366	667	6	a	a	DET
fnp-4366	667	7	panel	panel	NOUN
fnp-4366	667	8	of	of	ADP
fnp-4366	667	9	immunohistochemical	immunohistochemical	ADJ
fnp-4366	667	10	markers	marker	NOUN
fnp-4366	667	11	addressing	address	VERB
fnp-4366	667	12	oligodendroglial	oligodendroglial	ADJ
fnp-4366	667	13	lineage	lineage	NOUN
fnp-4366	667	14	(	(	PUNCT
fnp-4366	667	15	olig2	olig2	NOUN
fnp-4366	667	16	)	)	PUNCT
fnp-4366	667	17	,	,	PUNCT
fnp-4366	667	18	maturation	maturation	NOUN
fnp-4366	667	19	(	(	PUNCT
fnp-4366	667	20	breast	breast	NOUN
fnp-4366	667	21	cancer	cancer	NOUN
fnp-4366	667	22	amplifying	amplify	VERB
fnp-4366	667	23	sequence	sequence	NOUN
fnp-4366	667	24	1	1	NUM
fnp-4366	667	25	;	;	PUNCT
fnp-4366	667	26	bcas1	bcas1	NOUN
fnp-4366	667	27	)	)	PUNCT
fnp-4366	667	28	,	,	PUNCT
fnp-4366	667	29	proliferation	proliferation	NOUN
fnp-4366	667	30	(	(	PUNCT
fnp-4366	667	31	ki67	ki67	PROPN
fnp-4366	667	32	)	)	PUNCT
fnp-4366	667	33	,	,	PUNCT
fnp-4366	667	34	and	and	CCONJ
fnp-4366	667	35	myelination	myelination	NOUN
fnp-4366	667	36	(	(	PUNCT
fnp-4366	667	37	cnpase	cnpase	NOUN
fnp-4366	667	38	,	,	PUNCT
fnp-4366	667	39	nissl	nissl	NOUN
fnp-4366	667	40	-	-	PUNCT
fnp-4366	667	41	lfb	lfb	PROPN
fnp-4366	667	42	)	)	PUNCT
fnp-4366	667	43	were	be	AUX
fnp-4366	667	44	performed	perform	VERB
fnp-4366	667	45	.	.	PUNCT
fnp-4366	668	1	the	the	DET
fnp-4366	668	2	clinical	clinical	ADJ
fnp-4366	668	3	presentation	presentation	NOUN
fnp-4366	668	4	was	be	AUX
fnp-4366	668	5	not	not	PART
fnp-4366	668	6	significantly	significantly	ADV
fnp-4366	668	7	different	different	ADJ
fnp-4366	668	8	between	between	ADP
fnp-4366	668	9	both	both	DET
fnp-4366	668	10	study	study	NOUN
fnp-4366	668	11	cohorts	cohort	NOUN
fnp-4366	668	12	(	(	PUNCT
fnp-4366	668	13	moghe	moghe	VERB
fnp-4366	668	14	with	with	ADP
fnp-4366	668	15	or	or	CCONJ
fnp-4366	668	16	without	without	ADP
fnp-4366	668	17	slc35a2	slc35a2	NOUN
fnp-4366	668	18	mutations	mutation	NOUN
fnp-4366	668	19	)	)	PUNCT
fnp-4366	668	20	,	,	PUNCT
fnp-4366	668	21	e.g.	e.g.	ADV
fnp-4366	668	22	,	,	PUNCT
fnp-4366	668	23	median	median	ADJ
fnp-4366	668	24	seizure	seizure	NOUN
fnp-4366	668	25	onset	onset	NOUN
fnp-4366	668	26	was	be	AUX
fnp-4366	668	27	at	at	ADP
fnp-4366	668	28	1.2	1.2	NUM
fnp-4366	668	29	and	and	CCONJ
fnp-4366	668	30	1.8	1.8	NUM
fnp-4366	668	31	years	year	NOUN
fnp-4366	668	32	,	,	PUNCT
fnp-4366	668	33	respectively	respectively	ADV
fnp-4366	668	34	.	.	PUNCT
fnp-4366	669	1	patients	patient	NOUN
fnp-4366	669	2	were	be	AUX
fnp-4366	669	3	operated	operate	VERB
fnp-4366	669	4	at	at	ADP
fnp-4366	669	5	6.3	6.3	NUM
fnp-4366	669	6	and	and	CCONJ
fnp-4366	669	7	7.5	7.5	NUM
fnp-4366	669	8	years	year	NOUN
fnp-4366	669	9	,	,	PUNCT
fnp-4366	669	10	respectively	respectively	ADV
fnp-4366	669	11	,	,	PUNCT
fnp-4366	669	12	and	and	CCONJ
fnp-4366	669	13	89	89	NUM
fnp-4366	669	14	%	%	NOUN
fnp-4366	669	15	of	of	ADP
fnp-4366	669	16	lesions	lesion	NOUN
fnp-4366	669	17	were	be	AUX
fnp-4366	669	18	localized	localize	VERB
fnp-4366	669	19	in	in	ADP
fnp-4366	669	20	the	the	DET
fnp-4366	669	21	frontal	frontal	ADJ
fnp-4366	669	22	lobe	lobe	NOUN
fnp-4366	669	23	.	.	PUNCT
fnp-4366	670	1	however	however	ADV
fnp-4366	670	2	,	,	PUNCT
fnp-4366	670	3	patients	patient	NOUN
fnp-4366	670	4	with	with	ADP
fnp-4366	670	5	slc35a2	slc35a2	ADV
fnp-4366	670	6	mutated	mutate	VERB
fnp-4366	670	7	moghe	moghe	NOUN
fnp-4366	670	8	presented	present	VERB
fnp-4366	670	9	with	with	ADP
fnp-4366	670	10	more	more	ADV
fnp-4366	670	11	infantile	infantile	ADJ
fnp-4366	670	12	spasms	spasm	NOUN
fnp-4366	670	13	(	(	PUNCT
fnp-4366	670	14	61	61	NUM
fnp-4366	670	15	%	%	NOUN
fnp-4366	670	16	vs.	vs.	ADP
fnp-4366	670	17	25	25	NUM
fnp-4366	670	18	%	%	NOUN
fnp-4366	670	19	)	)	PUNCT
fnp-4366	670	20	.	.	PUNCT
fnp-4366	671	1	patchy	patchy	ADJ
fnp-4366	671	2	areas	area	NOUN
fnp-4366	671	3	of	of	ADP
fnp-4366	671	4	increased	increase	VERB
fnp-4366	671	5	oligodendroglial	oligodendroglial	ADJ
fnp-4366	671	6	cellularity	cellularity	NOUN
fnp-4366	671	7	and	and	CCONJ
fnp-4366	671	8	decreased	decrease	VERB
fnp-4366	671	9	myelination	myelination	NOUN
fnp-4366	671	10	were	be	AUX
fnp-4366	671	11	matching	match	VERB
fnp-4366	671	12	each	each	DET
fnp-4366	671	13	other	other	ADJ
fnp-4366	671	14	and	and	CCONJ
fnp-4366	671	15	were	be	AUX
fnp-4366	671	16	present	present	ADJ
fnp-4366	671	17	in	in	ADP
fnp-4366	671	18	both	both	DET
fnp-4366	671	19	groups	group	NOUN
fnp-4366	671	20	(	(	PUNCT
fnp-4366	671	21	figure	figure	NOUN
fnp-4366	671	22	1	1	NUM
fnp-4366	671	23	)	)	PUNCT
fnp-4366	671	24	.	.	PUNCT
fnp-4366	672	1	in	in	ADP
fnp-4366	672	2	addition	addition	NOUN
fnp-4366	672	3	,	,	PUNCT
fnp-4366	672	4	regenerative	regenerative	ADJ
fnp-4366	672	5	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	672	6	immunoreactive	immunoreactive	ADJ
fnp-4366	672	7	for	for	ADP
fnp-4366	672	8	bcas1	bcas1	NOUN
fnp-4366	672	9	were	be	AUX
fnp-4366	672	10	visible	visible	ADJ
fnp-4366	672	11	in	in	ADP
fnp-4366	672	12	both	both	DET
fnp-4366	672	13	moghe	moghe	ADJ
fnp-4366	672	14	groups	group	NOUN
fnp-4366	672	15	and	and	CCONJ
fnp-4366	672	16	both	both	DET
fnp-4366	672	17	groups	group	NOUN
fnp-4366	672	18	had	have	VERB
fnp-4366	672	19	higher	high	ADJ
fnp-4366	672	20	numbers	number	NOUN
fnp-4366	672	21	of	of	ADP
fnp-4366	672	22	bcas	bcas	NOUN
fnp-4366	672	23	-	-	PUNCT
fnp-4366	672	24	positive	positive	ADJ
fnp-4366	672	25	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	672	26	compared	compare	VERB
fnp-4366	672	27	to	to	ADP
fnp-4366	672	28	our	our	PRON
fnp-4366	672	29	age	age	NOUN
fnp-4366	672	30	-	-	PUNCT
fnp-4366	672	31	matched	match	VERB
fnp-4366	672	32	control	control	NOUN
fnp-4366	672	33	cohort	cohort	NOUN
fnp-4366	672	34	(	(	PUNCT
fnp-4366	672	35	figure	figure	NOUN
fnp-4366	672	36	2	2	NUM
fnp-4366	672	37	)	)	PUNCT
fnp-4366	672	38	.	.	PUNCT
fnp-4366	673	1	interestingly	interestingly	ADV
fnp-4366	673	2	,	,	PUNCT
fnp-4366	673	3	moghe	moghe	ADJ
fnp-4366	673	4	patients	patient	NOUN
fnp-4366	673	5	operated	operate	VERB
fnp-4366	673	6	at	at	ADP
fnp-4366	673	7	an	an	DET
fnp-4366	673	8	older	old	ADJ
fnp-4366	673	9	age	age	NOUN
fnp-4366	673	10	(	(	PUNCT
fnp-4366	673	11	>	>	SYM
fnp-4366	673	12	17	17	NUM
fnp-4366	673	13	years	year	NOUN
fnp-4366	673	14	;	;	PUNCT
fnp-4366	674	1	n=5	n=5	PROPN
fnp-4366	674	2	)	)	PUNCT
fnp-4366	674	3	showed	show	VERB
fnp-4366	674	4	lower	low	ADJ
fnp-4366	674	5	bcas	bcas	NOUN
fnp-4366	674	6	and	and	CCONJ
fnp-4366	674	7	oligodendroglial	oligodendroglial	ADJ
fnp-4366	674	8	cell	cell	NOUN
fnp-4366	674	9	numbers	number	NOUN
fnp-4366	674	10	which	which	PRON
fnp-4366	674	11	were	be	AUX
fnp-4366	674	12	similar	similar	ADJ
fnp-4366	674	13	to	to	ADP
fnp-4366	674	14	those	those	PRON
fnp-4366	674	15	observed	observe	VERB
fnp-4366	674	16	in	in	ADP
fnp-4366	674	17	our	our	PRON
fnp-4366	674	18	post	post	ADJ
fnp-4366	674	19	-	-	ADJ
fnp-4366	674	20	mortem	mortem	ADJ
fnp-4366	674	21	control	control	NOUN
fnp-4366	674	22	cohort	cohort	NOUN
fnp-4366	674	23	.	.	PUNCT
fnp-4366	675	1	myelination	myelination	NOUN
fnp-4366	675	2	deficits	deficit	NOUN
fnp-4366	675	3	were	be	AUX
fnp-4366	675	4	also	also	ADV
fnp-4366	675	5	less	less	ADV
fnp-4366	675	6	visible	visible	ADJ
fnp-4366	675	7	in	in	ADP
fnp-4366	675	8	moghe	moghe	ADJ
fnp-4366	675	9	patients	patient	NOUN
fnp-4366	675	10	operated	operate	VERB
fnp-4366	675	11	at	at	ADP
fnp-4366	675	12	an	an	DET
fnp-4366	675	13	older	old	ADJ
fnp-4366	675	14	age	age	NOUN
fnp-4366	675	15	(	(	PUNCT
fnp-4366	675	16	figure	figure	NOUN
fnp-4366	675	17	3	3	NUM
fnp-4366	675	18	)	)	PUNCT
fnp-4366	675	19	.	.	PUNCT
fnp-4366	676	1	in	in	ADP
fnp-4366	676	2	conclusion	conclusion	NOUN
fnp-4366	676	3	,	,	PUNCT
fnp-4366	676	4	our	our	PRON
fnp-4366	676	5	results	result	NOUN
fnp-4366	676	6	revealed	reveal	VERB
fnp-4366	676	7	a	a	DET
fnp-4366	676	8	similar	similar	ADJ
fnp-4366	676	9	genotype	genotype	NOUN
fnp-4366	676	10	-	-	PUNCT
fnp-4366	676	11	phenotype	phenotype	NOUN
fnp-4366	676	12	correlation	correlation	NOUN
fnp-4366	676	13	of	of	ADP
fnp-4366	676	14	moghe	moghe	NOUN
fnp-4366	676	15	w/o	w/o	ADP
fnp-4366	676	16	slc35a2	slc35a2	NOUN
fnp-4366	676	17	brain	brain	NOUN
fnp-4366	676	18	somatic	somatic	ADJ
fnp-4366	676	19	mutations	mutation	NOUN
fnp-4366	676	20	.	.	PUNCT
fnp-4366	677	1	these	these	DET
fnp-4366	677	2	results	result	NOUN
fnp-4366	677	3	further	far	ADV
fnp-4366	677	4	suggest	suggest	VERB
fnp-4366	677	5	a	a	DET
fnp-4366	677	6	similar	similar	ADJ
fnp-4366	677	7	oligodendroglial	oligodendroglial	ADJ
fnp-4366	677	8	regeneration	regeneration	NOUN
fnp-4366	677	9	and	and	CCONJ
fnp-4366	677	10	remyelination	remyelination	NOUN
fnp-4366	677	11	capacity	capacity	NOUN
fnp-4366	677	12	of	of	ADP
fnp-4366	677	13	early	early	ADJ
fnp-4366	677	14	-	-	PUNCT
fnp-4366	677	15	onset	onset	NOUN
fnp-4366	677	16	moghe	moghe	ADJ
fnp-4366	677	17	subtypes	subtype	NOUN
fnp-4366	677	18	,	,	PUNCT
fnp-4366	677	19	and	and	CCONJ
fnp-4366	677	20	that	that	SCONJ
fnp-4366	677	21	the	the	DET
fnp-4366	677	22	same	same	ADJ
fnp-4366	677	23	udp	udp	NOUN
fnp-4366	677	24	-	-	NOUN
fnp-4366	677	25	galactose	galactose	ADJ
fnp-4366	677	26	transport	transport	NOUN
fnp-4366	677	27	pathway	pathway	NOUN
fnp-4366	677	28	is	be	AUX
fnp-4366	677	29	likely	likely	ADJ
fnp-4366	677	30	to	to	PART
fnp-4366	677	31	play	play	VERB
fnp-4366	677	32	a	a	DET
fnp-4366	677	33	role	role	NOUN
fnp-4366	677	34	in	in	ADP
fnp-4366	677	35	moghe	moghe	NOUN
fnp-4366	677	36	with	with	ADP
fnp-4366	677	37	slc35a2	slc35a2	NOUN
fnp-4366	677	38	wildtype	wildtype	NOUN
fnp-4366	677	39	urging	urge	VERB
fnp-4366	677	40	for	for	ADP
fnp-4366	677	41	a	a	DET
fnp-4366	677	42	more	more	ADV
fnp-4366	677	43	systematic	systematic	ADJ
fnp-4366	677	44	approach	approach	NOUN
fnp-4366	677	45	deciphering	decipher	VERB
fnp-4366	677	46	the	the	DET
fnp-4366	677	47	pathogenic	pathogenic	ADJ
fnp-4366	677	48	aetiology	aetiology	NOUN
fnp-4366	677	49	of	of	ADP
fnp-4366	677	50	the	the	DET
fnp-4366	677	51	moghe	moghe	ADJ
fnp-4366	677	52	disease	disease	NOUN
fnp-4366	677	53	spectrum	spectrum	NOUN
fnp-4366	677	54	.	.	PUNCT
fnp-4366	678	1	figure	figure	NOUN
fnp-4366	678	2	1	1	NUM
fnp-4366	678	3	:	:	PUNCT
fnp-4366	678	4	patchy	patchy	ADJ
fnp-4366	678	5	regions	region	NOUN
fnp-4366	678	6	with	with	ADP
fnp-4366	678	7	increased	increase	VERB
fnp-4366	678	8	oligodendroglial	oligodendroglial	ADJ
fnp-4366	678	9	cell	cell	NOUN
fnp-4366	678	10	density	density	NOUN
fnp-4366	678	11	(	(	PUNCT
fnp-4366	678	12	heatmap	heatmap	VERB
fnp-4366	678	13	analysis	analysis	NOUN
fnp-4366	678	14	in	in	ADP
fnp-4366	678	15	a	a	DET
fnp-4366	678	16	,	,	PUNCT
fnp-4366	678	17	b	b	NOUN
fnp-4366	678	18	,	,	PUNCT
fnp-4366	678	19	e	e	NOUN
fnp-4366	678	20	)	)	PUNCT
fnp-4366	678	21	revealed	reveal	VERB
fnp-4366	678	22	a	a	DET
fnp-4366	678	23	matching	match	VERB
fnp-4366	678	24	overlay	overlay	NOUN
fnp-4366	678	25	with	with	ADP
fnp-4366	678	26	patchy	patchy	ADJ
fnp-4366	678	27	areas	area	NOUN
fnp-4366	678	28	of	of	ADP
fnp-4366	678	29	hypomyelination	hypomyelination	NOUN
fnp-4366	678	30	(	(	PUNCT
fnp-4366	678	31	f	f	NOUN
fnp-4366	678	32	)	)	PUNCT
fnp-4366	678	33	.	.	PUNCT
fnp-4366	679	1	moghe	moghe	VERB
fnp-4366	679	2	with	with	ADP
fnp-4366	679	3	slc35a2	slc35a2	NOUN
fnp-4366	679	4	mutations	mutation	NOUN
fnp-4366	679	5	in	in	ADP
fnp-4366	679	6	a	a	DET
fnp-4366	679	7	,	,	PUNCT
fnp-4366	679	8	c	c	NOUN
fnp-4366	679	9	-	-	SYM
fnp-4366	679	10	f	f	NOUN
fnp-4366	679	11	;	;	PUNCT
fnp-4366	679	12	b	b	X
fnp-4366	679	13	–	–	PUNCT
fnp-4366	679	14	moghe	moghe	NOUN
fnp-4366	679	15	without	without	ADP
fnp-4366	679	16	slc35a2	slc35a2	PROPN
fnp-4366	679	17	mutation	mutation	NOUN
fnp-4366	679	18	.	.	PUNCT
fnp-4366	680	1	figure	figure	NOUN
fnp-4366	680	2	2	2	NUM
fnp-4366	680	3	:	:	PUNCT
fnp-4366	680	4	all	all	DET
fnp-4366	680	5	moghe	moghe	ADJ
fnp-4366	680	6	samples	sample	NOUN
fnp-4366	680	7	revealed	reveal	VERB
fnp-4366	680	8	a	a	DET
fnp-4366	680	9	higher	high	ADJ
fnp-4366	680	10	number	number	NOUN
fnp-4366	680	11	of	of	ADP
fnp-4366	680	12	bcas1	bcas1	NOUN
fnp-4366	680	13	-	-	PUNCT
fnp-4366	680	14	immunoreactive	immunoreactive	ADJ
fnp-4366	680	15	oligodendrocytes	oligodendrocyte	NOUN
fnp-4366	680	16	at	at	ADP
fnp-4366	680	17	early	early	ADJ
fnp-4366	680	18	ages	age	NOUN
fnp-4366	680	19	,	,	PUNCT
fnp-4366	680	20	which	which	PRON
fnp-4366	680	21	normalize	normalize	VERB
fnp-4366	680	22	with	with	ADP
fnp-4366	680	23	further	further	ADJ
fnp-4366	680	24	maturation	maturation	NOUN
fnp-4366	680	25	.	.	PUNCT
fnp-4366	681	1	figure	figure	NOUN
fnp-4366	681	2	3	3	NUM
fnp-4366	681	3	:	:	PUNCT
fnp-4366	681	4	all	all	DET
fnp-4366	681	5	moghe	moghe	ADJ
fnp-4366	681	6	samples	sample	NOUN
fnp-4366	681	7	revealed	reveal	VERB
fnp-4366	681	8	a	a	DET
fnp-4366	681	9	higher	high	ADJ
fnp-4366	681	10	degree	degree	NOUN
fnp-4366	681	11	of	of	ADP
fnp-4366	681	12	hypomyelination	hypomyelination	NOUN
fnp-4366	681	13	(	(	PUNCT
fnp-4366	681	14	nissl	nissl	NOUN
fnp-4366	681	15	-	-	PUNCT
fnp-4366	681	16	luxol	luxol	NOUN
fnp-4366	681	17	-	-	PUNCT
fnp-4366	681	18	fast	fast	ADJ
fnp-4366	681	19	-	-	PUNCT
fnp-4366	681	20	blue	blue	ADJ
fnp-4366	681	21	,	,	PUNCT
fnp-4366	681	22	lfb	lfb	PROPN
fnp-4366	681	23	)	)	PUNCT
fnp-4366	681	24	at	at	ADP
fnp-4366	681	25	early	early	ADJ
fnp-4366	681	26	ages	age	NOUN
fnp-4366	681	27	,	,	PUNCT
fnp-4366	681	28	which	which	PRON
fnp-4366	681	29	normalize	normalize	VERB
fnp-4366	681	30	with	with	ADP
fnp-4366	681	31	further	further	ADJ
fnp-4366	681	32	maturation	maturation	NOUN
fnp-4366	681	33	.	.	PUNCT
fnp-4366	682	1	copyright	copyright	NOUN
fnp-4366	682	2	:	:	PUNCT
fnp-4366	682	3	©	©	PROPN
fnp-4366	682	4	2022	2022	NUM
fnp-4366	682	5	the	the	DET
fnp-4366	682	6	author(s	author(s	NOUN
fnp-4366	682	7	)	)	PUNCT
fnp-4366	682	8	.	.	PUNCT
fnp-4366	683	1	this	this	PRON
fnp-4366	683	2	is	be	AUX
fnp-4366	683	3	an	an	DET
fnp-4366	683	4	open	open	ADJ
fnp-4366	683	5	access	access	NOUN
fnp-4366	683	6	article	article	NOUN
fnp-4366	683	7	distributed	distribute	VERB
fnp-4366	683	8	under	under	ADP
fnp-4366	683	9	the	the	DET
fnp-4366	683	10	terms	term	NOUN
fnp-4366	683	11	of	of	ADP
fnp-4366	683	12	the	the	DET
fnp-4366	683	13	creative	creative	ADJ
fnp-4366	683	14	commons	common	NOUN
fnp-4366	683	15	attribution	attribution	NOUN
fnp-4366	683	16	4.0	4.0	NUM
fnp-4366	683	17	international	international	ADJ
fnp-4366	683	18	license	license	NOUN
fnp-4366	683	19	(	(	PUNCT
fnp-4366	683	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-4366	683	21	)	)	PUNCT
fnp-4366	683	22	,	,	PUNCT
fnp-4366	683	23	which	which	PRON
fnp-4366	683	24	permits	permit	VERB
fnp-4366	683	25	unrestricted	unrestricted	ADJ
fnp-4366	683	26	use	use	NOUN
fnp-4366	683	27	,	,	PUNCT
fnp-4366	683	28	distribution	distribution	NOUN
fnp-4366	683	29	,	,	PUNCT
fnp-4366	683	30	and	and	CCONJ
fnp-4366	683	31	reproduction	reproduction	NOUN
fnp-4366	683	32	in	in	ADP
fnp-4366	683	33	any	any	DET
fnp-4366	683	34	medium	medium	NOUN
fnp-4366	683	35	,	,	PUNCT
fnp-4366	683	36	provided	provide	VERB
fnp-4366	683	37	the	the	DET
fnp-4366	683	38	original	original	ADJ
fnp-4366	683	39	author	author	NOUN
fnp-4366	683	40	and	and	CCONJ
fnp-4366	683	41	source	source	NOUN
fnp-4366	683	42	are	be	AUX
fnp-4366	683	43	credited	credit	VERB
fnp-4366	683	44	,	,	PUNCT
fnp-4366	683	45	a	a	DET
fnp-4366	683	46	link	link	NOUN
fnp-4366	683	47	to	to	ADP
fnp-4366	683	48	the	the	DET
fnp-4366	683	49	creative	creative	ADJ
fnp-4366	683	50	commons	common	NOUN
fnp-4366	683	51	license	license	NOUN
fnp-4366	683	52	is	be	AUX
fnp-4366	683	53	provided	provide	VERB
fnp-4366	683	54	,	,	PUNCT
fnp-4366	683	55	and	and	CCONJ
fnp-4366	683	56	any	any	DET
fnp-4366	683	57	changes	change	NOUN
fnp-4366	683	58	are	be	AUX
fnp-4366	683	59	indicated	indicate	VERB
fnp-4366	683	60	.	.	PUNCT
fnp-4366	684	1	the	the	DET
fnp-4366	684	2	creative	creative	ADJ
fnp-4366	684	3	commons	common	NOUN
fnp-4366	684	4	public	public	ADJ
fnp-4366	684	5	domain	domain	NOUN
fnp-4366	684	6	dedication	dedication	NOUN
fnp-4366	684	7	waiver	waiver	NOUN
fnp-4366	684	8	(	(	PUNCT
fnp-4366	684	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-4366	684	10	)	)	PUNCT
fnp-4366	684	11	applies	apply	VERB
fnp-4366	684	12	to	to	ADP
fnp-4366	684	13	the	the	DET
fnp-4366	684	14	data	datum	NOUN
fnp-4366	684	15	made	make	VERB
fnp-4366	684	16	available	available	ADJ
fnp-4366	684	17	in	in	ADP
fnp-4366	684	18	this	this	DET
fnp-4366	684	19	article	article	NOUN
fnp-4366	684	20	,	,	PUNCT
fnp-4366	684	21	unless	unless	SCONJ
fnp-4366	684	22	otherwise	otherwise	ADV
fnp-4366	684	23	stated	state	VERB
fnp-4366	684	24	.	.	PUNCT