id sid tid token lemma pos fnp-4496 1 1 62nd 62nd ADJ fnp-4496 1 2 annual annual ADJ fnp-4496 1 3 meeting meeting NOUN fnp-4496 1 4 of of ADP fnp-4496 1 5 the the DET fnp-4496 1 6 canadian canadian PROPN fnp-4496 1 7 association association PROPN fnp-4496 1 8 of of ADP fnp-4496 1 9 neuropathologists neuropathologists PROPN fnp-4496 1 10 association association PROPN fnp-4496 1 11 canadienne canadienne PROPN fnp-4496 1 12 des des PROPN fnp-4496 1 13 neuropathologistes neuropathologistes PROPN fnp-4496 1 14 ( ( PUNCT fnp-4496 1 15 canp canp NOUN fnp-4496 1 16 - - PUNCT fnp-4496 1 17 acnp acnp NOUN fnp-4496 1 18 ) ) PUNCT fnp-4496 1 19 feel feel VERB fnp-4496 1 20 free free ADJ fnp-4496 1 21 to to PART fnp-4496 1 22 add add VERB fnp-4496 1 23 comments comment NOUN fnp-4496 1 24 by by ADP fnp-4496 1 25 clicking click VERB fnp-4496 1 26 these these DET fnp-4496 1 27 icons icon NOUN fnp-4496 1 28 on on ADP fnp-4496 1 29 the the DET fnp-4496 1 30 sidebar sidebar NOUN fnp-4496 1 31 free free ADJ fnp-4496 1 32 neuropathology neuropathology NOUN fnp-4496 1 33 3:25 3:25 NUM fnp-4496 1 34 ( ( PUNCT fnp-4496 1 35 2022 2022 NUM fnp-4496 1 36 ) ) PUNCT fnp-4496 1 37 meeting meeting NOUN fnp-4496 1 38 abstracts abstract VERB fnp-4496 1 39 62nd 62nd ADJ fnp-4496 1 40 annual annual ADJ fnp-4496 1 41 meeting meeting NOUN fnp-4496 1 42 of of ADP fnp-4496 1 43 the the DET fnp-4496 1 44 canadian canadian PROPN fnp-4496 1 45 association association PROPN fnp-4496 1 46 of of ADP fnp-4496 1 47 neuropathologists neuropathologists PROPN fnp-4496 1 48 association association PROPN fnp-4496 1 49 canadienne canadienne PROPN fnp-4496 1 50 des des PROPN fnp-4496 1 51 neuropathologistes neuropathologistes PROPN fnp-4496 1 52 ( ( PUNCT fnp-4496 1 53 canp canp NOUN fnp-4496 1 54 - - PUNCT fnp-4496 1 55 acnp acnp NOUN fnp-4496 1 56 ) ) PUNCT fnp-4496 1 57 meeting meeting NOUN fnp-4496 1 58 abstracts abstract VERB fnp-4496 1 59 october october PROPN fnp-4496 1 60 13–15 13–15 PROPN fnp-4496 1 61 , , PUNCT fnp-4496 1 62 2022 2022 NUM fnp-4496 1 63 saskatoon saskatoon NOUN fnp-4496 1 64 , , PUNCT fnp-4496 1 65 sk sk NOUN fnp-4496 1 66 submitted submit VERB fnp-4496 1 67 : : PUNCT fnp-4496 1 68 31 31 NUM fnp-4496 1 69 october october PROPN fnp-4496 1 70 2022 2022 NUM fnp-4496 1 71 accepted accept VERB fnp-4496 1 72 : : PUNCT fnp-4496 1 73 01 01 NUM fnp-4496 1 74 november november PROPN fnp-4496 1 75 2022 2022 NUM fnp-4496 1 76 published publish VERB fnp-4496 1 77 : : PUNCT fnp-4496 1 78 16 16 NUM fnp-4496 1 79 november november PROPN fnp-4496 1 80 2022 2022 NUM fnp-4496 1 81     SPACE fnp-4496 1 82 the the DET fnp-4496 1 83 canadian canadian PROPN fnp-4496 1 84 association association NOUN fnp-4496 1 85 of of ADP fnp-4496 1 86 neuropathologist neuropathologist ADJ fnp-4496 1 87 – – PUNCT fnp-4496 1 88 association association PROPN fnp-4496 1 89 canadienne canadienne PROPN fnp-4496 1 90 des des X fnp-4496 1 91 neuropathologistes neuropathologistes PROPN fnp-4496 1 92 ( ( PUNCT fnp-4496 1 93 canp canp NOUN fnp-4496 1 94 - - PUNCT fnp-4496 1 95 acnp acnp NOUN fnp-4496 1 96 ) ) PUNCT fnp-4496 1 97 held hold VERB fnp-4496 1 98 their their PRON fnp-4496 1 99 62nd 62nd ADJ fnp-4496 1 100 annual annual ADJ fnp-4496 1 101 meeting meeting NOUN fnp-4496 1 102 at at ADP fnp-4496 1 103 the the DET fnp-4496 1 104 delta delta NOUN fnp-4496 1 105 bessborough bessborough NOUN fnp-4496 1 106 in in ADP fnp-4496 1 107 saskatoon saskatoon PROPN fnp-4496 1 108 , , PUNCT fnp-4496 1 109 sk sk VERB fnp-4496 1 110 from from ADP fnp-4496 1 111 october october PROPN fnp-4496 1 112 13th 13th NOUN fnp-4496 1 113 to to ADP fnp-4496 1 114 15th 15th ADJ fnp-4496 1 115 , , PUNCT fnp-4496 1 116 2022 2022 NUM fnp-4496 1 117 , , PUNCT fnp-4496 1 118 under under ADP fnp-4496 1 119 the the DET fnp-4496 1 120 leadership leadership NOUN fnp-4496 1 121 of of ADP fnp-4496 1 122 dr dr PROPN fnp-4496 1 123 . . PROPN fnp-4496 1 124 robert robert PROPN fnp-4496 1 125 hammond hammond PROPN fnp-4496 1 126 , , PUNCT fnp-4496 1 127 president president NOUN fnp-4496 1 128 of of ADP fnp-4496 1 129 the the DET fnp-4496 1 130 canp canp NOUN fnp-4496 1 131 - - PUNCT fnp-4496 1 132 acnp acnp ADJ fnp-4496 1 133 , , PUNCT fnp-4496 1 134 dr dr PROPN fnp-4496 1 135 . . PROPN fnp-4496 1 136 peter peter PROPN fnp-4496 1 137 schutz schutz PROPN fnp-4496 1 138 , , PUNCT fnp-4496 1 139 secretary secretary NOUN fnp-4496 1 140 treasurer treasurer NOUN fnp-4496 1 141 of of ADP fnp-4496 1 142 the the DET fnp-4496 1 143 canp canp NOUN fnp-4496 1 144 - - PUNCT fnp-4496 1 145 acnp acnp NOUN fnp-4496 1 146 , , PUNCT fnp-4496 1 147 and and CCONJ fnp-4496 1 148 with with ADP fnp-4496 1 149 technical technical ADJ fnp-4496 1 150 support support NOUN fnp-4496 1 151 from from ADP fnp-4496 1 152 canp canp ADJ fnp-4496 1 153 administrator administrator NOUN fnp-4496 1 154 , , PUNCT fnp-4496 1 155 colleen colleen PROPN fnp-4496 1 156 fifield fifield NOUN fnp-4496 1 157 . . PUNCT fnp-4496 2 1 the the DET fnp-4496 2 2 academic academic ADJ fnp-4496 2 3 program program NOUN fnp-4496 2 4 comprised comprise VERB fnp-4496 2 5 15 15 NUM fnp-4496 2 6 scientific scientific ADJ fnp-4496 2 7 abstracts abstract NOUN fnp-4496 2 8 , , PUNCT fnp-4496 2 9 9 9 NUM fnp-4496 2 10 unknown unknown ADJ fnp-4496 2 11 cases case NOUN fnp-4496 2 12 , , PUNCT fnp-4496 2 13 a a DET fnp-4496 2 14 mini mini NOUN fnp-4496 2 15 - - NOUN fnp-4496 2 16 symposium symposium NOUN fnp-4496 2 17 on on ADP fnp-4496 2 18 competence competence NOUN fnp-4496 2 19 based base VERB fnp-4496 2 20 medical medical ADJ fnp-4496 2 21 education education NOUN fnp-4496 2 22 in in ADP fnp-4496 2 23 neuropathology neuropathology NOUN fnp-4496 2 24 , , PUNCT fnp-4496 2 25 and and CCONJ fnp-4496 2 26 the the DET fnp-4496 2 27 presidential presidential ADJ fnp-4496 2 28 symposium symposium NOUN fnp-4496 2 29 on on ADP fnp-4496 2 30 multiple multiple ADJ fnp-4496 2 31 sclerosis sclerosis NOUN fnp-4496 2 32 and and CCONJ fnp-4496 2 33 immune immune ADJ fnp-4496 2 34 mediated mediate VERB fnp-4496 2 35 demyelinating demyelinate VERB fnp-4496 2 36 disease disease NOUN fnp-4496 2 37 . . PUNCT fnp-4496 3 1 digital digital ADJ fnp-4496 3 2 pathology pathology NOUN fnp-4496 3 3 images image VERB fnp-4496 3 4 from from ADP fnp-4496 3 5 the the DET fnp-4496 3 6 9 9 NUM fnp-4496 3 7 unknown unknown ADJ fnp-4496 3 8 cases case NOUN fnp-4496 3 9 are be AUX fnp-4496 3 10 available available ADJ fnp-4496 3 11 for for ADP fnp-4496 3 12 viewing view VERB fnp-4496 3 13 online online ADV fnp-4496 3 14 ( ( PUNCT fnp-4496 3 15 www.canp.ca www.canp.ca NOUN fnp-4496 3 16 ) ) PUNCT fnp-4496 3 17 . . PUNCT fnp-4496 4 1 the the DET fnp-4496 4 2 unknown unknown ADJ fnp-4496 4 3 case case NOUN fnp-4496 4 4 sessions session NOUN fnp-4496 4 5 were be AUX fnp-4496 4 6 moderated moderate VERB fnp-4496 4 7 by by ADP fnp-4496 4 8 dr dr PROPN fnp-4496 4 9 . . PROPN fnp-4496 4 10 andrew andrew PROPN fnp-4496 4 11 gao gao PROPN fnp-4496 4 12 . . PUNCT fnp-4496 5 1 the the DET fnp-4496 5 2 presidential presidential ADJ fnp-4496 5 3 symposium symposium NOUN fnp-4496 5 4 2022 2022 NUM fnp-4496 5 5 on on ADP fnp-4496 5 6 multiple multiple ADJ fnp-4496 5 7 sclerosis sclerosis NOUN fnp-4496 5 8 and and CCONJ fnp-4496 5 9 immune immune ADJ fnp-4496 5 10 mediated mediate VERB fnp-4496 5 11 demyelinating demyelinate VERB fnp-4496 5 12 disease disease NOUN fnp-4496 5 13 featured feature VERB fnp-4496 5 14 the the DET fnp-4496 5 15 gordon gordon PROPN fnp-4496 5 16 mathieson mathieson PROPN fnp-4496 5 17 lecture lecture NOUN fnp-4496 5 18 given give VERB fnp-4496 5 19 by by ADP fnp-4496 5 20 dr dr PROPN fnp-4496 5 21 . . PROPN fnp-4496 5 22 g. g. PROPN fnp-4496 5 23 r. r. PROPN fnp-4496 5 24 wayne wayne PROPN fnp-4496 5 25 moore moore PROPN fnp-4496 5 26 entitled entitle VERB fnp-4496 5 27 demyelination demyelination NOUN fnp-4496 5 28 , , PUNCT fnp-4496 5 29 multiple multiple ADJ fnp-4496 5 30 sclerosis sclerosis NOUN fnp-4496 5 31 , , PUNCT fnp-4496 5 32 and and CCONJ fnp-4496 5 33 mri mri NOUN fnp-4496 5 34 and and CCONJ fnp-4496 5 35 the the DET fnp-4496 5 36 david david PROPN fnp-4496 5 37 robertson robertson PROPN fnp-4496 5 38 lecture lecture NOUN fnp-4496 5 39 given give VERB fnp-4496 5 40 by by ADP fnp-4496 5 41 dr dr PROPN fnp-4496 5 42 . . PROPN fnp-4496 5 43 michael michael PROPN fnp-4496 5 44 levin levin PROPN fnp-4496 5 45 entitled entitle VERB fnp-4496 5 46 multiple multiple ADJ fnp-4496 5 47 sclerosis sclerosis NOUN fnp-4496 5 48 and and CCONJ fnp-4496 5 49 future future ADJ fnp-4496 5 50 therapies therapy NOUN fnp-4496 5 51 . . PUNCT fnp-4496 6 1 the the DET fnp-4496 6 2 program program NOUN fnp-4496 6 3 was be AUX fnp-4496 6 4 completed complete VERB fnp-4496 6 5 by by ADP fnp-4496 6 6 three three NUM fnp-4496 6 7 invited invite VERB fnp-4496 6 8 presentations presentation NOUN fnp-4496 6 9 with with ADP fnp-4496 6 10 dr dr PROPN fnp-4496 6 11 . . PROPN fnp-4496 6 12 e. e. PROPN fnp-4496 6 13 ann ann PROPN fnp-4496 6 14 yeh yeh PROPN fnp-4496 6 15 presenting present VERB fnp-4496 6 16 on on ADP fnp-4496 6 17 pediatric pediatric ADJ fnp-4496 6 18 multiple multiple ADJ fnp-4496 6 19 sclerosis sclerosis NOUN fnp-4496 6 20 and and CCONJ fnp-4496 6 21 immune immune ADJ fnp-4496 6 22 mediated mediate VERB fnp-4496 6 23 demyelination demyelination NOUN fnp-4496 6 24 , , PUNCT fnp-4496 6 25 dr dr PROPN fnp-4496 6 26 . . PROPN fnp-4496 6 27 tanja tanja PROPN fnp-4496 6 28 kuhlmann kuhlmann PROPN fnp-4496 6 29 presenting present VERB fnp-4496 6 30 on on ADP fnp-4496 6 31 neuropathology neuropathology NOUN fnp-4496 6 32 of of ADP fnp-4496 6 33 ms ms NOUN fnp-4496 6 34 and and CCONJ fnp-4496 6 35 stem stem NOUN fnp-4496 6 36 cells cell NOUN fnp-4496 6 37 and and CCONJ fnp-4496 6 38 dr dr PROPN fnp-4496 6 39 . . PROPN fnp-4496 6 40 pamela pamela PROPN fnp-4496 6 41 kanellis kanellis PROPN fnp-4496 6 42 presenting present VERB fnp-4496 6 43 on on ADP fnp-4496 6 44 outlook outlook NOUN fnp-4496 6 45 of of ADP fnp-4496 6 46 patients patient NOUN fnp-4496 6 47 and and CCONJ fnp-4496 6 48 public public ADJ fnp-4496 6 49 on on ADP fnp-4496 6 50 ms ms PROPN fnp-4496 6 51 research research NOUN fnp-4496 6 52 and and CCONJ fnp-4496 6 53 treatment treatment NOUN fnp-4496 6 54 in in ADP fnp-4496 6 55 canada canada PROPN fnp-4496 6 56 . . PUNCT fnp-4496 7 1 the the DET fnp-4496 7 2 mary mary PROPN fnp-4496 7 3 tom tom PROPN fnp-4496 7 4 award award PROPN fnp-4496 7 5 for for ADP fnp-4496 7 6 best good ADJ fnp-4496 7 7 clinical clinical ADJ fnp-4496 7 8 science science NOUN fnp-4496 7 9 presentation presentation NOUN fnp-4496 7 10 by by ADP fnp-4496 7 11 a a DET fnp-4496 7 12 trainee trainee NOUN fnp-4496 7 13 went go VERB fnp-4496 7 14 to to ADP fnp-4496 7 15 dr dr PROPN fnp-4496 7 16 . . PROPN fnp-4496 7 17 christopher christopher PROPN fnp-4496 7 18 newell newell PROPN fnp-4496 7 19 ( ( PUNCT fnp-4496 7 20 supervisor supervisor NOUN fnp-4496 7 21 dr dr PROPN fnp-4496 7 22 . . PROPN fnp-4496 7 23 j. j. PROPN fnp-4496 7 24 joseph joseph PROPN fnp-4496 7 25 ) ) PUNCT fnp-4496 7 26 , , PUNCT fnp-4496 7 27 and and CCONJ fnp-4496 7 28 the the DET fnp-4496 7 29 morrison morrison PROPN fnp-4496 7 30 h. h. PROPN fnp-4496 7 31 finlayson finlayson PROPN fnp-4496 7 32 award award PROPN fnp-4496 7 33 for for ADP fnp-4496 7 34 best good ADJ fnp-4496 7 35 basic basic ADJ fnp-4496 7 36 science science NOUN fnp-4496 7 37 presentation presentation NOUN fnp-4496 7 38 by by ADP fnp-4496 7 39 a a DET fnp-4496 7 40 trainee trainee NOUN fnp-4496 7 41 was be AUX fnp-4496 7 42 won win VERB fnp-4496 7 43 by by ADP fnp-4496 7 44 dr dr PROPN fnp-4496 7 45 . . PROPN fnp-4496 7 46 erin erin PROPN fnp-4496 7 47 stephenson stephenson PROPN fnp-4496 7 48 ( ( PUNCT fnp-4496 7 49 supervisor supervisor NOUN fnp-4496 7 50 dr dr PROPN fnp-4496 7 51 . . PROPN fnp-4496 8 1 v.w v.w PROPN fnp-4496 8 2 . . PROPN fnp-4496 8 3 yong yong PROPN fnp-4496 8 4 ) ) PUNCT fnp-4496 8 5 . . PUNCT fnp-4496 9 1 the the DET fnp-4496 9 2 following follow VERB fnp-4496 9 3 abstracts abstract NOUN fnp-4496 9 4 were be AUX fnp-4496 9 5 presented present VERB fnp-4496 9 6 at at ADP fnp-4496 9 7 the the DET fnp-4496 9 8 62nd 62nd ADJ fnp-4496 9 9 annual annual ADJ fnp-4496 9 10 meeting meeting NOUN fnp-4496 9 11 of of ADP fnp-4496 9 12 the the DET fnp-4496 9 13 canadian canadian PROPN fnp-4496 9 14 association association NOUN fnp-4496 9 15 of of ADP fnp-4496 9 16 neuropathologists neuropathologist NOUN fnp-4496 9 17 – – PUNCT fnp-4496 9 18 association association PROPN fnp-4496 9 19 candienne candienne PROPN fnp-4496 9 20 des des PROPN fnp-4496 9 21 neuropathologistes neuropathologistes PROPN fnp-4496 9 22 ( ( PUNCT fnp-4496 9 23 canp canp NOUN fnp-4496 9 24 - - PUNCT fnp-4496 9 25 acnp acnp NOUN fnp-4496 9 26 ) ) PUNCT fnp-4496 9 27 in in ADP fnp-4496 9 28 october october PROPN fnp-4496 9 29 2022 2022 NUM fnp-4496 9 30 . . PUNCT fnp-4496 9 31     SPACE fnp-4496 10 1 https://doi.org/10.17879/freeneuropathology-2022-4496 https://doi.org/10.17879/freeneuropathology-2022-4496 NOUN fnp-4496 10 2 keywords keyword NOUN fnp-4496 10 3 : : PUNCT fnp-4496 10 4 canadian canadian ADJ fnp-4496 10 5 association association NOUN fnp-4496 10 6 of of ADP fnp-4496 10 7 neuropathologists neuropathologist NOUN fnp-4496 10 8 , , PUNCT fnp-4496 10 9 canp canp NOUN fnp-4496 10 10 , , PUNCT fnp-4496 10 11 meeting meet VERB fnp-4496 10 12 abstracts abstract NOUN fnp-4496 10 13 , , PUNCT fnp-4496 10 14 62nd 62nd PROPN fnp-4496 10 15 meeting meeting NOUN fnp-4496 10 16 oct oct PROPN fnp-4496 10 17 . . PROPN fnp-4496 10 18 2022 2022 NUM fnp-4496 10 19 contents content NOUN fnp-4496 10 20 abstract abstract ADJ fnp-4496 10 21     SPACE fnp-4496 10 22 1 1 NUM fnp-4496 10 23 effects effect NOUN fnp-4496 10 24 of of ADP fnp-4496 10 25 prenatal prenatal ADJ fnp-4496 10 26 cocaine cocaine NOUN fnp-4496 10 27 exposure exposure NOUN fnp-4496 10 28 on on ADP fnp-4496 10 29 the the DET fnp-4496 10 30 human human ADJ fnp-4496 10 31 developing develop VERB fnp-4496 10 32 brain brain NOUN fnp-4496 10 33 . . PUNCT fnp-4496 11 1 a a DET fnp-4496 11 2 neuropathological neuropathological ADJ fnp-4496 11 3 study study NOUN fnp-4496 11 4 . . PUNCT fnp-4496 12 1 abstract abstract ADJ fnp-4496 12 2     SPACE fnp-4496 12 3 2 2 NUM fnp-4496 12 4 : : PUNCT fnp-4496 12 5 utilizing utilize VERB fnp-4496 12 6 neurodevelopmental neurodevelopmental ADJ fnp-4496 12 7 time time NOUN fnp-4496 12 8 windows window NOUN fnp-4496 12 9 of of ADP fnp-4496 12 10 hypoxic hypoxic ADJ fnp-4496 12 11 - - PUNCT fnp-4496 12 12 ischemic ischemic ADJ fnp-4496 12 13 pathology pathology NOUN fnp-4496 12 14 to to PART fnp-4496 12 15 infer infer VERB fnp-4496 12 16 brain brain NOUN fnp-4496 12 17 maturity maturity NOUN fnp-4496 12 18 in in ADP fnp-4496 12 19 patients patient NOUN fnp-4496 12 20 with with ADP fnp-4496 12 21 congenital congenital ADJ fnp-4496 12 22 cardiothoracic cardiothoracic NOUN fnp-4496 12 23 defects defect NOUN fnp-4496 12 24 abstract abstract ADJ fnp-4496 12 25     SPACE fnp-4496 12 26 3 3 NUM fnp-4496 12 27 : : PUNCT fnp-4496 12 28 spinal spinal NOUN fnp-4496 12 29 nerve nerve NOUN fnp-4496 12 30 root root NOUN fnp-4496 12 31 blood blood NOUN fnp-4496 12 32 in in ADP fnp-4496 12 33 pediatric pediatric ADJ fnp-4496 12 34 autopsy autopsy ADJ fnp-4496 12 35 cases case NOUN fnp-4496 12 36 is be AUX fnp-4496 12 37 not not PART fnp-4496 12 38 necessarily necessarily ADV fnp-4496 12 39 a a DET fnp-4496 12 40 marker marker NOUN fnp-4496 12 41 of of ADP fnp-4496 12 42 trauma trauma NOUN fnp-4496 12 43 at at ADP fnp-4496 12 44 that that DET fnp-4496 12 45 site site NOUN fnp-4496 12 46 abstract abstract NOUN fnp-4496 12 47     SPACE fnp-4496 12 48 4 4 NUM fnp-4496 12 49 : : PUNCT fnp-4496 12 50 multifocal multifocal ADJ fnp-4496 12 51 necrotizing necrotizing NOUN fnp-4496 12 52 leukoencephalopathy leukoencephalopathy ADJ fnp-4496 12 53 post post ADJ fnp-4496 12 54 - - ADJ fnp-4496 12 55 covid-19 covid-19 ADJ fnp-4496 12 56 infection infection NOUN fnp-4496 12 57 : : PUNCT fnp-4496 12 58 expanding expand VERB fnp-4496 12 59 the the DET fnp-4496 12 60 “ " PUNCT fnp-4496 12 61 neuro neuro PROPN fnp-4496 12 62 - - PUNCT fnp-4496 12 63 covid covid NOUN fnp-4496 12 64 ” " PUNCT fnp-4496 12 65 spectrum spectrum NOUN fnp-4496 12 66 abstract abstract NOUN fnp-4496 12 67     SPACE fnp-4496 12 68 5 5 NUM fnp-4496 12 69 : : PUNCT fnp-4496 12 70 the the DET fnp-4496 12 71 international international ADJ fnp-4496 12 72 disseminated disseminate VERB fnp-4496 12 73 pediatric pediatric ADJ fnp-4496 12 74 low low ADJ fnp-4496 12 75 grade grade NOUN fnp-4496 12 76 glioma glioma NOUN fnp-4496 12 77 consortium consortium NOUN fnp-4496 12 78 : : PUNCT fnp-4496 12 79 project project NOUN fnp-4496 12 80 goals goal NOUN fnp-4496 12 81 and and CCONJ fnp-4496 12 82 preliminary preliminary ADJ fnp-4496 12 83 results result NOUN fnp-4496 12 84 abstract abstract ADJ fnp-4496 12 85     SPACE fnp-4496 12 86 6 6 NUM fnp-4496 12 87 : : PUNCT fnp-4496 12 88 glioblastoma glioblastoma NOUN fnp-4496 12 89 , , PUNCT fnp-4496 12 90 idh idh NOUN fnp-4496 12 91 - - PUNCT fnp-4496 12 92 wildtype wildtype NOUN fnp-4496 12 93 with with ADP fnp-4496 12 94 fgfr3 fgfr3 PROPN fnp-4496 12 95 - - PUNCT fnp-4496 12 96 tacc3 tacc3 NOUN fnp-4496 12 97 fusion fusion NOUN fnp-4496 12 98 has have VERB fnp-4496 12 99 unusual unusual ADJ fnp-4496 12 100 histologic histologic ADJ fnp-4496 12 101 , , PUNCT fnp-4496 12 102 molecular molecular ADJ fnp-4496 12 103 and and CCONJ fnp-4496 12 104 clinicoradiologic clinicoradiologic ADJ fnp-4496 12 105 characteristics characteristic NOUN fnp-4496 12 106 abstract abstract NOUN fnp-4496 12 107     SPACE fnp-4496 12 108 7 7 NUM fnp-4496 12 109 : : PUNCT fnp-4496 12 110 infiltrative infiltrative ADJ fnp-4496 12 111 pattern pattern NOUN fnp-4496 12 112 in in ADP fnp-4496 12 113 pediatric pediatric ADJ fnp-4496 12 114 ganglioglioma ganglioglioma ADJ fnp-4496 12 115 abstract abstract NOUN fnp-4496 12 116     SPACE fnp-4496 12 117 8 8 NUM fnp-4496 12 118 : : PUNCT fnp-4496 12 119 clinical clinical ADJ fnp-4496 12 120 implementation implementation NOUN fnp-4496 12 121 of of ADP fnp-4496 12 122 methylation methylation NOUN fnp-4496 12 123 profiling profiling NOUN fnp-4496 12 124 : : PUNCT fnp-4496 12 125 the the DET fnp-4496 12 126 sickkids sickkid NOUN fnp-4496 12 127 experience experience PROPN fnp-4496 12 128 abstract abstract NOUN fnp-4496 12 129     SPACE fnp-4496 12 130 9 9 NUM fnp-4496 12 131 : : PUNCT fnp-4496 12 132 cerebral cerebral ADJ fnp-4496 12 133 amyloidoma amyloidoma NOUN fnp-4496 12 134 : : PUNCT fnp-4496 12 135 pathological pathological ADJ fnp-4496 12 136 findings finding NOUN fnp-4496 12 137 from from ADP fnp-4496 12 138 diagnostic diagnostic ADJ fnp-4496 12 139 biopsy biopsy NOUN fnp-4496 12 140 to to ADP fnp-4496 12 141 autopsy autopsy ADJ fnp-4496 12 142 abstract abstract NOUN fnp-4496 12 143     SPACE fnp-4496 12 144 10 10 NUM fnp-4496 12 145 : : PUNCT fnp-4496 12 146 identification identification NOUN fnp-4496 12 147 and and CCONJ fnp-4496 12 148 validation validation NOUN fnp-4496 12 149 of of ADP fnp-4496 12 150 immunohistochemical immunohistochemical ADJ fnp-4496 12 151 antibodies antibody NOUN fnp-4496 12 152 against against ADP fnp-4496 12 153 transcriptomically transcriptomically ADV fnp-4496 12 154 distinct distinct ADJ fnp-4496 12 155 human human ADJ fnp-4496 12 156 hippocampal hippocampal NOUN fnp-4496 12 157 astrocyte astrocyte NOUN fnp-4496 12 158 subtypes subtype NOUN fnp-4496 12 159 abstract abstract ADJ fnp-4496 12 160     SPACE fnp-4496 12 161 11 11 NUM fnp-4496 12 162 : : PUNCT fnp-4496 12 163 cadherin-23 cadherin-23 NOUN fnp-4496 12 164 is be AUX fnp-4496 12 165 essential essential ADJ fnp-4496 12 166 for for ADP fnp-4496 12 167 the the DET fnp-4496 12 168 normal normal ADJ fnp-4496 12 169 organisation organisation NOUN fnp-4496 12 170 of of ADP fnp-4496 12 171 cerebellar cerebellar ADJ fnp-4496 12 172 mossy mossy PROPN fnp-4496 12 173 fibre fibre NOUN fnp-4496 12 174 synapses synapse VERB fnp-4496 12 175 abstract abstract ADJ fnp-4496 12 176     SPACE fnp-4496 12 177 12 12 NUM fnp-4496 12 178 : : PUNCT fnp-4496 12 179 the the DET fnp-4496 12 180 extracellular extracellular ADJ fnp-4496 12 181 matrix matrix NOUN fnp-4496 12 182 transcriptome transcriptome NOUN fnp-4496 12 183 following follow VERB fnp-4496 12 184 demyelination demyelination NOUN fnp-4496 12 185 abstract abstract NOUN fnp-4496 12 186     SPACE fnp-4496 12 187 13 13 NUM fnp-4496 12 188 : : PUNCT fnp-4496 12 189 nodding nod VERB fnp-4496 12 190 syndrome syndrome NOUN fnp-4496 12 191 : : PUNCT fnp-4496 12 192 characterizing characterize VERB fnp-4496 12 193 the the DET fnp-4496 12 194 newest new ADJ fnp-4496 12 195 tau tau NOUN fnp-4496 12 196 proteinopathy proteinopathy ADJ fnp-4496 12 197 in in ADP fnp-4496 12 198 africa africa PROPN fnp-4496 12 199 abstract abstract PROPN fnp-4496 12 200     SPACE fnp-4496 12 201 14 14 NUM fnp-4496 12 202 : : PUNCT fnp-4496 12 203 mri mri ADJ fnp-4496 12 204 - - PUNCT fnp-4496 12 205 pathological pathological ADJ fnp-4496 12 206 correlations correlation NOUN fnp-4496 12 207 show show VERB fnp-4496 12 208 differential differential ADJ fnp-4496 12 209 patterns pattern NOUN fnp-4496 12 210 of of ADP fnp-4496 12 211 ex ex PRON fnp-4496 12 212 vivo vivo ADJ fnp-4496 12 213 texture texture NOUN fnp-4496 12 214 in in ADP fnp-4496 12 215 als als NOUN fnp-4496 12 216 abstract abstract ADJ fnp-4496 12 217     SPACE fnp-4496 12 218 15 15 NUM fnp-4496 12 219 : : PUNCT fnp-4496 12 220 lymphoid lymphoid NOUN fnp-4496 12 221 and and CCONJ fnp-4496 12 222 plasma plasma NOUN fnp-4496 12 223 - - PUNCT fnp-4496 12 224 cell cell NOUN fnp-4496 12 225 infiltrates infiltrate NOUN fnp-4496 12 226 with with ADP fnp-4496 12 227 amorphous amorphous ADJ fnp-4496 12 228 eosinophilic eosinophilic ADJ fnp-4496 12 229 material material NOUN fnp-4496 12 230 deposition deposition NOUN fnp-4496 12 231 in in ADP fnp-4496 12 232 the the DET fnp-4496 12 233 leptomeninges leptomeninge NOUN fnp-4496 12 234 : : PUNCT fnp-4496 12 235 a a DET fnp-4496 12 236 challenging challenging ADJ fnp-4496 12 237 case case NOUN fnp-4496 12 238         SPACE fnp-4496 12 239 abstract abstract ADJ fnp-4496 12 240 1 1 NUM fnp-4496 12 241 free free ADJ fnp-4496 12 242 neuropathol neuropathol NOUN fnp-4496 12 243 3:25:4 3:25:4 NUM fnp-4496 12 244 effects effect NOUN fnp-4496 12 245 of of ADP fnp-4496 12 246 prenatal prenatal ADJ fnp-4496 12 247 cocaine cocaine NOUN fnp-4496 12 248 exposure exposure NOUN fnp-4496 12 249 on on ADP fnp-4496 12 250 the the DET fnp-4496 12 251 human human ADJ fnp-4496 12 252 developing develop VERB fnp-4496 12 253 brain brain NOUN fnp-4496 12 254 . . PUNCT fnp-4496 13 1 a a DET fnp-4496 13 2 neuropathological neuropathological ADJ fnp-4496 13 3 study study NOUN fnp-4496 13 4 . . PUNCT fnp-4496 14 1 catherine catherine PROPN fnp-4496 14 2 fallet fallet PROPN fnp-4496 14 3 - - PUNCT fnp-4496 14 4 bianco1 bianco1 PROPN fnp-4496 14 5 , , PUNCT fnp-4496 14 6 mubina mubina PROPN fnp-4496 14 7 jovanovic1 jovanovic1 PROPN fnp-4496 14 8 , , PUNCT fnp-4496 14 9 dorothée dorothée PROPN fnp-4496 14 10 bouron bouron PROPN fnp-4496 14 11 - - PUNCT fnp-4496 14 12 dal dal ADJ fnp-4496 14 13 soglio1 soglio1 PROPN fnp-4496 14 14 1department 1department NUM fnp-4496 14 15 of of ADP fnp-4496 14 16 pathology pathology PROPN fnp-4496 14 17 , , PUNCT fnp-4496 14 18 hôpital hôpital PROPN fnp-4496 14 19 sainte sainte PROPN fnp-4496 14 20 - - PUNCT fnp-4496 14 21 justine justine PROPN fnp-4496 14 22 - - PUNCT fnp-4496 14 23 université université PROPN fnp-4496 14 24 de de PROPN fnp-4496 14 25 montreal montreal PROPN fnp-4496 14 26 , , PUNCT fnp-4496 14 27 montreal montreal PROPN fnp-4496 14 28 , , PUNCT fnp-4496 14 29 qc qc PROPN fnp-4496 14 30 , , PUNCT fnp-4496 14 31 canada canada PROPN fnp-4496 14 32 recent recent ADJ fnp-4496 14 33 studies study NOUN fnp-4496 14 34 report report VERB fnp-4496 14 35 that that SCONJ fnp-4496 14 36 cocaine cocaine NOUN fnp-4496 14 37 use use NOUN fnp-4496 14 38 among among ADP fnp-4496 14 39 pregnant pregnant ADJ fnp-4496 14 40 women woman NOUN fnp-4496 14 41 continues continue VERB fnp-4496 14 42 to to PART fnp-4496 14 43 be be AUX fnp-4496 14 44 a a DET fnp-4496 14 45 public public ADJ fnp-4496 14 46 health health NOUN fnp-4496 14 47 concern concern NOUN fnp-4496 14 48 . . PUNCT fnp-4496 15 1 experimental experimental ADJ fnp-4496 15 2 studies study NOUN fnp-4496 15 3 have have AUX fnp-4496 15 4 shown show VERB fnp-4496 15 5 that that SCONJ fnp-4496 15 6 prenatal prenatal ADJ fnp-4496 15 7 cocaine cocaine NOUN fnp-4496 15 8 exposure exposure NOUN fnp-4496 15 9 is be AUX fnp-4496 15 10 responsible responsible ADJ fnp-4496 15 11 for for ADP fnp-4496 15 12 disturbances disturbance NOUN fnp-4496 15 13 affecting affect VERB fnp-4496 15 14 neurogenesis neurogenesis NOUN fnp-4496 15 15 , , PUNCT fnp-4496 15 16 neuronal neuronal ADJ fnp-4496 15 17 migration migration NOUN fnp-4496 15 18 and and CCONJ fnp-4496 15 19 neurotransmitter neurotransmitter NOUN fnp-4496 15 20 systems system NOUN fnp-4496 15 21 . . PUNCT fnp-4496 16 1 however however ADV fnp-4496 16 2 , , PUNCT fnp-4496 16 3 human human NOUN fnp-4496 16 4 - - PUNCT fnp-4496 16 5 based base VERB fnp-4496 16 6 studies study NOUN fnp-4496 16 7 are be AUX fnp-4496 16 8 impacted impact VERB fnp-4496 16 9 by by ADP fnp-4496 16 10 confounding confound VERB fnp-4496 16 11 factors factor NOUN fnp-4496 16 12 : : PUNCT fnp-4496 16 13 multi multi ADJ fnp-4496 16 14 - - ADJ fnp-4496 16 15 drug drug ADJ fnp-4496 16 16 use use NOUN fnp-4496 16 17 , , PUNCT fnp-4496 16 18 lack lack NOUN fnp-4496 16 19 of of ADP fnp-4496 16 20 neuropathological neuropathological ADJ fnp-4496 16 21 studies study NOUN fnp-4496 16 22 . . PUNCT fnp-4496 17 1 we we PRON fnp-4496 17 2 describe describe VERB fnp-4496 17 3 the the DET fnp-4496 17 4 neuropathological neuropathological ADJ fnp-4496 17 5 phenotype phenotype NOUN fnp-4496 17 6 observed observe VERB fnp-4496 17 7 in in ADP fnp-4496 17 8 two two NUM fnp-4496 17 9 fetuses fetus NOUN fnp-4496 17 10 after after ADP fnp-4496 17 11 prenatal prenatal ADJ fnp-4496 17 12 exposure exposure NOUN fnp-4496 17 13 to to ADP fnp-4496 17 14 cocaine cocaine NOUN fnp-4496 17 15 . . PUNCT fnp-4496 18 1 in in ADP fnp-4496 18 2 a a DET fnp-4496 18 3 34 34 NUM fnp-4496 18 4 - - PUNCT fnp-4496 18 5 year year NOUN fnp-4496 18 6 - - PUNCT fnp-4496 18 7 old old ADJ fnp-4496 18 8 woman woman NOUN fnp-4496 18 9 using use VERB fnp-4496 18 10 cocaine cocaine NOUN fnp-4496 18 11 for for ADP fnp-4496 18 12 several several ADJ fnp-4496 18 13 years year NOUN fnp-4496 18 14 , , PUNCT fnp-4496 18 15 ultrasonography ultrasonography NOUN fnp-4496 18 16 at at ADP fnp-4496 18 17 24 24 NUM fnp-4496 18 18 gestational gestational ADJ fnp-4496 18 19 weeks week NOUN fnp-4496 18 20 revealed reveal VERB fnp-4496 18 21 a a DET fnp-4496 18 22 severe severe ADJ fnp-4496 18 23 microcephaly microcephaly NOUN fnp-4496 18 24 with with ADP fnp-4496 18 25 a a DET fnp-4496 18 26 severe severe ADJ fnp-4496 18 27 global global ADJ fnp-4496 18 28 disorganization disorganization NOUN fnp-4496 18 29 of of ADP fnp-4496 18 30 brain brain NOUN fnp-4496 18 31 development development NOUN fnp-4496 18 32 . . PUNCT fnp-4496 19 1 in in ADP fnp-4496 19 2 the the DET fnp-4496 19 3 second second ADJ fnp-4496 19 4 case case NOUN fnp-4496 19 5 , , PUNCT fnp-4496 19 6 a a DET fnp-4496 19 7 19 19 NUM fnp-4496 19 8 - - PUNCT fnp-4496 19 9 year year NOUN fnp-4496 19 10 - - PUNCT fnp-4496 19 11 old old ADJ fnp-4496 19 12 mother mother NOUN fnp-4496 19 13 using use VERB fnp-4496 19 14 cocaine cocaine NOUN fnp-4496 19 15 , , PUNCT fnp-4496 19 16 ultrasonography ultrasonography NOUN fnp-4496 19 17 at at ADP fnp-4496 19 18 20 20 NUM fnp-4496 19 19 weeks week NOUN fnp-4496 19 20 showed show VERB fnp-4496 19 21 a a DET fnp-4496 19 22 severe severe ADJ fnp-4496 19 23 microcephaly microcephaly NOUN fnp-4496 19 24 with with ADP fnp-4496 19 25 bilateral bilateral ADJ fnp-4496 19 26 schizencephaly schizencephaly NOUN fnp-4496 19 27 resulting result VERB fnp-4496 19 28 from from ADP fnp-4496 19 29 multiple multiple ADJ fnp-4496 19 30 hemorrhages hemorrhage NOUN fnp-4496 19 31 . . PUNCT fnp-4496 20 1 a a DET fnp-4496 20 2 vasoconstriction vasoconstriction NOUN fnp-4496 20 3 of of ADP fnp-4496 20 4 maternal maternal ADJ fnp-4496 20 5 - - PUNCT fnp-4496 20 6 fetal fetal ADJ fnp-4496 20 7 arteries artery NOUN fnp-4496 20 8 is be AUX fnp-4496 20 9 , , PUNCT fnp-4496 20 10 classically classically ADV fnp-4496 20 11 , , PUNCT fnp-4496 20 12 the the DET fnp-4496 20 13 mechanism mechanism NOUN fnp-4496 20 14 considered consider VERB fnp-4496 20 15 responsible responsible ADJ fnp-4496 20 16 for for ADP fnp-4496 20 17 the the DET fnp-4496 20 18 disturbed disturbed ADJ fnp-4496 20 19 brain brain NOUN fnp-4496 20 20 development development NOUN fnp-4496 20 21 . . PUNCT fnp-4496 21 1 a a DET fnp-4496 21 2 vascular vascular ADJ fnp-4496 21 3 disruption disruption NOUN fnp-4496 21 4 is be AUX fnp-4496 21 5 probably probably ADV fnp-4496 21 6 the the DET fnp-4496 21 7 cause cause NOUN fnp-4496 21 8 of of ADP fnp-4496 21 9 the the DET fnp-4496 21 10 lesions lesion NOUN fnp-4496 21 11 in in ADP fnp-4496 21 12 the the DET fnp-4496 21 13 second second ADJ fnp-4496 21 14 case case NOUN fnp-4496 21 15 . . PUNCT fnp-4496 22 1 the the DET fnp-4496 22 2 changes change NOUN fnp-4496 22 3 in in ADP fnp-4496 22 4 the the DET fnp-4496 22 5 first first ADJ fnp-4496 22 6 case case NOUN fnp-4496 22 7 are be AUX fnp-4496 22 8 similar similar ADJ fnp-4496 22 9 to to ADP fnp-4496 22 10 those those PRON fnp-4496 22 11 generated generate VERB fnp-4496 22 12 in in ADP fnp-4496 22 13 experimental experimental ADJ fnp-4496 22 14 models model NOUN fnp-4496 22 15 and and CCONJ fnp-4496 22 16 confirm confirm VERB fnp-4496 22 17 that that PRON fnp-4496 22 18 cocaine cocaine NOUN fnp-4496 22 19 has have VERB fnp-4496 22 20 direct direct ADJ fnp-4496 22 21 toxic toxic ADJ fnp-4496 22 22 effects effect NOUN fnp-4496 22 23 on on ADP fnp-4496 22 24 the the DET fnp-4496 22 25 neurogenesis neurogenesis NOUN fnp-4496 22 26 , , PUNCT fnp-4496 22 27 gliogenesis gliogenesis NOUN fnp-4496 22 28 and and CCONJ fnp-4496 22 29 neuronal neuronal ADJ fnp-4496 22 30 migration migration NOUN fnp-4496 22 31 in in ADP fnp-4496 22 32 the the DET fnp-4496 22 33 developing develop VERB fnp-4496 22 34 brain brain NOUN fnp-4496 22 35 . . PUNCT fnp-4496 23 1 the the DET fnp-4496 23 2 wide wide ADJ fnp-4496 23 3 spectrum spectrum NOUN fnp-4496 23 4 of of ADP fnp-4496 23 5 brain brain NOUN fnp-4496 23 6 lesions lesion NOUN fnp-4496 23 7 depends depend VERB fnp-4496 23 8 on on ADP fnp-4496 23 9 multiple multiple ADJ fnp-4496 23 10 factors factor NOUN fnp-4496 23 11 ; ; PUNCT fnp-4496 23 12 the the DET fnp-4496 23 13 most most ADV fnp-4496 23 14 important important ADJ fnp-4496 23 15 is be AUX fnp-4496 23 16 probably probably ADV fnp-4496 23 17 the the DET fnp-4496 23 18 moment moment NOUN fnp-4496 23 19 of of ADP fnp-4496 23 20 exposure exposure NOUN fnp-4496 23 21 in in ADP fnp-4496 23 22 gestation gestation NOUN fnp-4496 23 23 , , PUNCT fnp-4496 23 24 as as ADV fnp-4496 23 25 well well ADV fnp-4496 23 26 as as ADP fnp-4496 23 27 dose dose NOUN fnp-4496 23 28 , , PUNCT fnp-4496 23 29 frequency frequency NOUN fnp-4496 23 30 of of ADP fnp-4496 23 31 cocaine cocaine NOUN fnp-4496 23 32 use use NOUN fnp-4496 23 33 , , PUNCT fnp-4496 23 34 and and CCONJ fnp-4496 23 35 genetic genetic ADJ fnp-4496 23 36 susceptibility susceptibility NOUN fnp-4496 23 37 . . PUNCT fnp-4496 23 38     SPACE fnp-4496 24 1 abstract abstract ADJ fnp-4496 24 2 2 2 NUM fnp-4496 24 3 free free ADJ fnp-4496 24 4 neuropathol neuropathol NOUN fnp-4496 24 5 3:25:5 3:25:5 NUM fnp-4496 24 6 utilizing utilize VERB fnp-4496 24 7 neurodevelopmental neurodevelopmental ADJ fnp-4496 24 8 time time NOUN fnp-4496 24 9 windows window NOUN fnp-4496 24 10 of of ADP fnp-4496 24 11 hypoxic hypoxic ADJ fnp-4496 24 12 - - PUNCT fnp-4496 24 13 ischemic ischemic ADJ fnp-4496 24 14 pathology pathology NOUN fnp-4496 24 15 to to PART fnp-4496 24 16 infer infer VERB fnp-4496 24 17 brain brain NOUN fnp-4496 24 18 maturity maturity NOUN fnp-4496 24 19 in in ADP fnp-4496 24 20 patients patient NOUN fnp-4496 24 21 with with ADP fnp-4496 24 22 congenital congenital ADJ fnp-4496 24 23 cardiothoracic cardiothoracic NOUN fnp-4496 24 24 defects defect NOUN fnp-4496 24 25 karina karina PROPN fnp-4496 24 26 chornenka1 chornenka1 PROPN fnp-4496 24 27 , , PUNCT fnp-4496 24 28 christopher christopher PROPN fnp-4496 24 29 dunham2 dunham2 PROPN fnp-4496 24 30 1 1 NUM fnp-4496 24 31 department department NOUN fnp-4496 24 32 of of ADP fnp-4496 24 33 pathology pathology NOUN fnp-4496 24 34 and and CCONJ fnp-4496 24 35 laboratory laboratory NOUN fnp-4496 24 36 medicine medicine NOUN fnp-4496 24 37 , , PUNCT fnp-4496 24 38 university university NOUN fnp-4496 24 39 of of ADP fnp-4496 24 40 british british PROPN fnp-4496 24 41 columbia columbia PROPN fnp-4496 24 42 , , PUNCT fnp-4496 24 43 vancouver vancouver PROPN fnp-4496 24 44 , , PUNCT fnp-4496 24 45 bc bc PROPN fnp-4496 24 46 , , PUNCT fnp-4496 24 47 canada canada PROPN fnp-4496 24 48 2 2 NUM fnp-4496 24 49 division division NOUN fnp-4496 24 50 of of ADP fnp-4496 24 51 anatomical anatomical ADJ fnp-4496 24 52 pathology pathology NOUN fnp-4496 24 53 , , PUNCT fnp-4496 24 54 children child NOUN fnp-4496 24 55 ’s ’s PART fnp-4496 24 56 and and CCONJ fnp-4496 24 57 women woman NOUN fnp-4496 24 58 ’s ’s PART fnp-4496 24 59 health health NOUN fnp-4496 24 60 centre centre PROPN fnp-4496 24 61 of of ADP fnp-4496 24 62 bc bc PROPN fnp-4496 24 63 , , PUNCT fnp-4496 24 64 vancouver vancouver PROPN fnp-4496 24 65 , , PUNCT fnp-4496 24 66 bc bc PROPN fnp-4496 24 67 , , PUNCT fnp-4496 24 68 canada canada PROPN fnp-4496 24 69 neuroradiologic neuroradiologic PROPN fnp-4496 24 70 investigations investigation NOUN fnp-4496 24 71 have have AUX fnp-4496 24 72 demonstrated demonstrate VERB fnp-4496 24 73 that that SCONJ fnp-4496 24 74 cerebral cerebral ADJ fnp-4496 24 75 development development NOUN fnp-4496 24 76 is be AUX fnp-4496 24 77 delayed delay VERB fnp-4496 24 78 by by ADP fnp-4496 24 79 2 2 NUM fnp-4496 24 80 - - SYM fnp-4496 24 81 4 4 NUM fnp-4496 24 82 weeks week NOUN fnp-4496 24 83 in in ADP fnp-4496 24 84 infants infant NOUN fnp-4496 24 85 suffering suffer VERB fnp-4496 24 86 from from ADP fnp-4496 24 87 congenital congenital ADJ fnp-4496 24 88 heart heart NOUN fnp-4496 24 89 defects defect NOUN fnp-4496 24 90 and and CCONJ fnp-4496 24 91 congenital congenital ADJ fnp-4496 24 92 diaphragmatic diaphragmatic ADJ fnp-4496 24 93 hernia hernia NOUN fnp-4496 24 94 ( ( PUNCT fnp-4496 24 95 chd chd PROPN fnp-4496 24 96 / / SYM fnp-4496 24 97 cdh cdh PROPN fnp-4496 24 98 ) ) PUNCT fnp-4496 24 99 . . PUNCT fnp-4496 25 1 these these DET fnp-4496 25 2 estimates estimate NOUN fnp-4496 25 3 are be AUX fnp-4496 25 4 based base VERB fnp-4496 25 5 upon upon SCONJ fnp-4496 25 6 application application NOUN fnp-4496 25 7 of of ADP fnp-4496 25 8 the the DET fnp-4496 25 9 “ " PUNCT fnp-4496 25 10 total total ADJ fnp-4496 25 11 maturation maturation NOUN fnp-4496 25 12 score score NOUN fnp-4496 25 13 ” " PUNCT fnp-4496 25 14 ( ( PUNCT fnp-4496 25 15 tms tms PROPN fnp-4496 25 16 ) ) PUNCT fnp-4496 25 17 system system NOUN fnp-4496 25 18 that that PRON fnp-4496 25 19 evaluates evaluate VERB fnp-4496 25 20 brain brain NOUN fnp-4496 25 21 development development NOUN fnp-4496 25 22 using use VERB fnp-4496 25 23 magnetic magnetic ADJ fnp-4496 25 24 resonance resonance NOUN fnp-4496 25 25 imaging imaging NOUN fnp-4496 25 26 ( ( PUNCT fnp-4496 25 27 mri mri NOUN fnp-4496 25 28 ) ) PUNCT fnp-4496 25 29 by by ADP fnp-4496 25 30 assessing assess VERB fnp-4496 25 31 myelination myelination NOUN fnp-4496 25 32 , , PUNCT fnp-4496 25 33 cortical cortical ADJ fnp-4496 25 34 gyration gyration NOUN fnp-4496 25 35 , , PUNCT fnp-4496 25 36 insular insular ADJ fnp-4496 25 37 development development NOUN fnp-4496 25 38 , , PUNCT fnp-4496 25 39 t1 t1 PROPN fnp-4496 25 40 white white PROPN fnp-4496 25 41 matter matter PROPN fnp-4496 25 42 signal signal NOUN fnp-4496 25 43 intensity intensity NOUN fnp-4496 25 44 and and CCONJ fnp-4496 25 45 the the DET fnp-4496 25 46 involution involution NOUN fnp-4496 25 47 of of ADP fnp-4496 25 48 the the DET fnp-4496 25 49 germinal germinal ADJ fnp-4496 25 50 matrix matrix NOUN fnp-4496 25 51 ( ( PUNCT fnp-4496 25 52 n n X fnp-4496 25 53 engl engl PROPN fnp-4496 25 54 j j PROPN fnp-4496 25 55 med med PROPN fnp-4496 25 56 2007;357 2007;357 NUM fnp-4496 25 57 : : PUNCT fnp-4496 25 58 1928 1928 NUM fnp-4496 25 59 - - SYM fnp-4496 25 60 1938 1938 NUM fnp-4496 25 61 , , PUNCT fnp-4496 25 62 j j PROPN fnp-4496 25 63 pediatr pediatr PROPN fnp-4496 25 64 surg surg NOUN fnp-4496 25 65 2012;47:453 2012;47:453 PROPN fnp-4496 25 66 - - NUM fnp-4496 25 67 461 461 NUM fnp-4496 25 68 ) ) PUNCT fnp-4496 25 69 . . PUNCT fnp-4496 26 1 these these DET fnp-4496 26 2 infants infant NOUN fnp-4496 26 3 often often ADV fnp-4496 26 4 require require VERB fnp-4496 26 5 surgical surgical ADJ fnp-4496 26 6 correction correction NOUN fnp-4496 26 7 of of ADP fnp-4496 26 8 their their PRON fnp-4496 26 9 malformations malformation NOUN fnp-4496 26 10 shortly shortly ADV fnp-4496 26 11 after after ADP fnp-4496 26 12 birth birth NOUN fnp-4496 26 13 , , PUNCT fnp-4496 26 14 but but CCONJ fnp-4496 26 15 unfortunately unfortunately ADV fnp-4496 26 16 some some PRON fnp-4496 26 17 do do AUX fnp-4496 26 18 not not PART fnp-4496 26 19 survive survive VERB fnp-4496 26 20 . . PUNCT fnp-4496 27 1 of of ADP fnp-4496 27 2 those those PRON fnp-4496 27 3 coming come VERB fnp-4496 27 4 to to ADP fnp-4496 27 5 autopsy autopsy ADJ fnp-4496 27 6 , , PUNCT fnp-4496 27 7 it it PRON fnp-4496 27 8 is be AUX fnp-4496 27 9 not not PART fnp-4496 27 10 uncommon uncommon ADJ fnp-4496 27 11 to to PART fnp-4496 27 12 encounter encounter VERB fnp-4496 27 13 acute acute ADJ fnp-4496 27 14 hypoxic hypoxic ADV fnp-4496 27 15 ischemic ischemic ADJ fnp-4496 27 16 injury injury NOUN fnp-4496 27 17 ( ( PUNCT fnp-4496 27 18 hii hii PROPN fnp-4496 27 19 ) ) PUNCT fnp-4496 27 20 . . PUNCT fnp-4496 28 1 we we PRON fnp-4496 28 2 examined examine VERB fnp-4496 28 3 three three NUM fnp-4496 28 4 individuals individual NOUN fnp-4496 28 5 born bear VERB fnp-4496 28 6 at at ADP fnp-4496 28 7 term term NOUN fnp-4496 28 8 with with ADP fnp-4496 28 9 chd chd PROPN fnp-4496 28 10 / / SYM fnp-4496 28 11 cdh cdh PROPN fnp-4496 28 12 , , PUNCT fnp-4496 28 13 ranging range VERB fnp-4496 28 14 in in ADP fnp-4496 28 15 age age NOUN fnp-4496 28 16 from from ADP fnp-4496 28 17 3 3 NUM fnp-4496 28 18 to to PART fnp-4496 28 19 5 5 NUM fnp-4496 28 20 months month NOUN fnp-4496 28 21 , , PUNCT fnp-4496 28 22 who who PRON fnp-4496 28 23 died die VERB fnp-4496 28 24 shortly shortly ADV fnp-4496 28 25 after after ADP fnp-4496 28 26 surgery surgery NOUN fnp-4496 28 27 and and CCONJ fnp-4496 28 28 displayed display VERB fnp-4496 28 29 evidence evidence NOUN fnp-4496 28 30 of of ADP fnp-4496 28 31 neuropathology neuropathology NOUN fnp-4496 28 32 that that PRON fnp-4496 28 33 included include VERB fnp-4496 28 34 acute acute ADJ fnp-4496 28 35 hii hii PROPN fnp-4496 28 36 characterized characterize VERB fnp-4496 28 37 by by ADP fnp-4496 28 38 periventricular periventricular ADJ fnp-4496 28 39 leukomalacia leukomalacia PROPN fnp-4496 28 40 ( ( PUNCT fnp-4496 28 41 pvl pvl NOUN fnp-4496 28 42 ) ) PUNCT fnp-4496 28 43 and and CCONJ fnp-4496 28 44 pontosubicular pontosubicular ADJ fnp-4496 28 45 necrosis necrosis NOUN fnp-4496 28 46 ( ( PUNCT fnp-4496 28 47 psn psn NOUN fnp-4496 28 48 ) ) PUNCT fnp-4496 28 49 . . PUNCT fnp-4496 29 1 pvl pvl PROPN fnp-4496 29 2 and and CCONJ fnp-4496 29 3 psn psn PROPN fnp-4496 29 4 are be AUX fnp-4496 29 5 typically typically ADV fnp-4496 29 6 encountered encounter VERB fnp-4496 29 7 in in ADP fnp-4496 29 8 the the DET fnp-4496 29 9 context context NOUN fnp-4496 29 10 of of ADP fnp-4496 29 11 prematurity prematurity NOUN fnp-4496 29 12 and and CCONJ fnp-4496 29 13 occur occur VERB fnp-4496 29 14 during during ADP fnp-4496 29 15 specific specific ADJ fnp-4496 29 16 developmental developmental ADJ fnp-4496 29 17 time time NOUN fnp-4496 29 18 windows window NOUN fnp-4496 29 19 ( ( PUNCT fnp-4496 29 20 i.e. i.e. X fnp-4496 29 21 , , PUNCT fnp-4496 29 22 pvl pvl NOUN fnp-4496 29 23 : : PUNCT fnp-4496 29 24 24 24 NUM fnp-4496 29 25 - - SYM fnp-4496 29 26 32 32 NUM fnp-4496 29 27 weeks week NOUN fnp-4496 29 28 gestational gestational ADJ fnp-4496 29 29 age age NOUN fnp-4496 29 30 ; ; PUNCT fnp-4496 29 31 psn psn PROPN fnp-4496 29 32 : : PUNCT fnp-4496 29 33 20 20 NUM fnp-4496 29 34 weeks week NOUN fnp-4496 29 35 gestational gestational ADJ fnp-4496 29 36 age age NOUN fnp-4496 29 37 – – PUNCT fnp-4496 29 38 2 2 NUM fnp-4496 29 39 months month NOUN fnp-4496 29 40 postnatal postnatal ADJ fnp-4496 29 41 ) ) PUNCT fnp-4496 29 42 ( ( PUNCT fnp-4496 29 43 acta acta PROPN fnp-4496 29 44 neuropathol neuropathol PROPN fnp-4496 29 45 1995;90:7 1995;90:7 AUX fnp-4496 29 46 - - SYM fnp-4496 29 47 10 10 NUM fnp-4496 29 48 , , PUNCT fnp-4496 29 49 acta acta PROPN fnp-4496 29 50 neuropathol neuropathol NOUN fnp-4496 29 51 2005;110:563 2005;110:563 NUM fnp-4496 29 52 - - SYM fnp-4496 29 53 578 578 NUM fnp-4496 29 54 ) ) PUNCT fnp-4496 29 55 . . PUNCT fnp-4496 30 1 given give VERB fnp-4496 30 2 the the DET fnp-4496 30 3 ages age NOUN fnp-4496 30 4 of of ADP fnp-4496 30 5 the the DET fnp-4496 30 6 affected affected ADJ fnp-4496 30 7 individuals individual NOUN fnp-4496 30 8 herein herein NOUN fnp-4496 30 9 , , PUNCT fnp-4496 30 10 we we PRON fnp-4496 30 11 suggest suggest VERB fnp-4496 30 12 that that SCONJ fnp-4496 30 13 the the DET fnp-4496 30 14 presence presence NOUN fnp-4496 30 15 of of ADP fnp-4496 30 16 premature premature ADJ fnp-4496 30 17 - - PUNCT fnp-4496 30 18 type type NOUN fnp-4496 30 19 neuropathology neuropathology NOUN fnp-4496 30 20 in in ADP fnp-4496 30 21 the the DET fnp-4496 30 22 form form NOUN fnp-4496 30 23 of of ADP fnp-4496 30 24 acute acute ADJ fnp-4496 30 25 hii hii PROPN fnp-4496 30 26 could could AUX fnp-4496 30 27 be be AUX fnp-4496 30 28 used use VERB fnp-4496 30 29 to to PART fnp-4496 30 30 support support VERB fnp-4496 30 31 the the DET fnp-4496 30 32 hat hat NOUN fnp-4496 30 33 infants infant NOUN fnp-4496 30 34 with with ADP fnp-4496 30 35 chd chd PROPN fnp-4496 30 36 / / SYM fnp-4496 30 37 cdh cdh PROPN fnp-4496 30 38 incur incur PROPN fnp-4496 30 39 delayed delay VERB fnp-4496 30 40 brain brain NOUN fnp-4496 30 41 development development NOUN fnp-4496 30 42 . . PUNCT fnp-4496 31 1 moreover moreover ADV fnp-4496 31 2 , , PUNCT fnp-4496 31 3 based base VERB fnp-4496 31 4 on on ADP fnp-4496 31 5 our our PRON fnp-4496 31 6 observations observation NOUN fnp-4496 31 7 we we PRON fnp-4496 31 8 propose propose VERB fnp-4496 31 9 that that SCONJ fnp-4496 31 10 the the DET fnp-4496 31 11 delay delay NOUN fnp-4496 31 12 in in ADP fnp-4496 31 13 cerebral cerebral ADJ fnp-4496 31 14 development development NOUN fnp-4496 31 15 could could AUX fnp-4496 31 16 be be AUX fnp-4496 31 17 longer long ADJ fnp-4496 31 18 than than ADP fnp-4496 31 19 previous previous ADJ fnp-4496 31 20 estimates estimate NOUN fnp-4496 31 21 using use VERB fnp-4496 31 22 mri mri NOUN fnp-4496 31 23 . . PUNCT fnp-4496 31 24     SPACE fnp-4496 32 1 abstract abstract ADJ fnp-4496 32 2 3 3 NUM fnp-4496 32 3 free free ADJ fnp-4496 32 4 neuropathol neuropathol NOUN fnp-4496 32 5 3:25:6 3:25:6 NUM fnp-4496 32 6 spinal spinal NOUN fnp-4496 32 7 nerve nerve NOUN fnp-4496 32 8 root root NOUN fnp-4496 32 9 blood blood NOUN fnp-4496 32 10 in in ADP fnp-4496 32 11 pediatric pediatric ADJ fnp-4496 32 12 autopsy autopsy ADJ fnp-4496 32 13 cases case NOUN fnp-4496 32 14 is be AUX fnp-4496 32 15 not not PART fnp-4496 32 16 necessarily necessarily ADV fnp-4496 32 17 a a DET fnp-4496 32 18 marker marker NOUN fnp-4496 32 19 of of ADP fnp-4496 32 20 trauma trauma NOUN fnp-4496 32 21 at at ADP fnp-4496 32 22 that that DET fnp-4496 32 23 site site NOUN fnp-4496 32 24 marc marc PROPN fnp-4496 32 25 r. r. PROPN fnp-4496 32 26 del del PROPN fnp-4496 32 27 bigio1 bigio1 PROPN fnp-4496 32 28 1 1 NUM fnp-4496 32 29 department department NOUN fnp-4496 32 30 of of ADP fnp-4496 32 31 pathology pathology PROPN fnp-4496 32 32 , , PUNCT fnp-4496 32 33 university university PROPN fnp-4496 32 34 of of ADP fnp-4496 32 35 manitoba manitoba PROPN fnp-4496 32 36 and and CCONJ fnp-4496 32 37 diagnostic diagnostic PROPN fnp-4496 32 38 services service NOUN fnp-4496 32 39 manitoba manitoba PROPN fnp-4496 32 40 , , PUNCT fnp-4496 32 41 winnipeg winnipeg PROPN fnp-4496 32 42 , , PUNCT fnp-4496 32 43 mb mb PROPN fnp-4496 32 44 , , PUNCT fnp-4496 32 45 canada canada PROPN fnp-4496 32 46 increasingly increasingly ADV fnp-4496 32 47 , , PUNCT fnp-4496 32 48 the the DET fnp-4496 32 49 forensic forensic ADJ fnp-4496 32 50 examination examination NOUN fnp-4496 32 51 of of ADP fnp-4496 32 52 suspected suspect VERB fnp-4496 32 53 child child NOUN fnp-4496 32 54 abuse abuse NOUN fnp-4496 32 55 cases case NOUN fnp-4496 32 56 includes include VERB fnp-4496 32 57 dissection dissection NOUN fnp-4496 32 58 of of ADP fnp-4496 32 59 the the DET fnp-4496 32 60 entire entire ADJ fnp-4496 32 61 cervical cervical ADJ fnp-4496 32 62 spine spine NOUN fnp-4496 32 63 ; ; PUNCT fnp-4496 32 64 hemorrhage hemorrhage NOUN fnp-4496 32 65 along along ADP fnp-4496 32 66 nerve nerve NOUN fnp-4496 32 67 roots root NOUN fnp-4496 32 68 is be AUX fnp-4496 32 69 postulated postulate VERB fnp-4496 32 70 to to PART fnp-4496 32 71 indicate indicate VERB fnp-4496 32 72 forces force NOUN fnp-4496 32 73 exerted exert VERB fnp-4496 32 74 by by ADP fnp-4496 32 75 shaking shake VERB fnp-4496 32 76 . . PUNCT fnp-4496 33 1 seventy seventy NUM fnp-4496 33 2 pediatric pediatric ADJ fnp-4496 33 3 spinal spinal NOUN fnp-4496 33 4 cords cord NOUN fnp-4496 33 5 encased encase VERB fnp-4496 33 6 in in ADP fnp-4496 33 7 dura dura NOUN fnp-4496 33 8 mater mater NOUN fnp-4496 33 9 were be AUX fnp-4496 33 10 examined examine VERB fnp-4496 33 11 ( ( PUNCT fnp-4496 33 12 including include VERB fnp-4496 33 13 12 12 NUM fnp-4496 33 14 en en ADP fnp-4496 33 15 bloc bloc ADJ fnp-4496 33 16 cervical cervical ADJ fnp-4496 33 17 spines spine NOUN fnp-4496 33 18 ) ) PUNCT fnp-4496 33 19 ; ; PUNCT fnp-4496 33 20 age age NOUN fnp-4496 33 21 0 0 NUM fnp-4496 33 22 - - SYM fnp-4496 33 23 58 58 NUM fnp-4496 33 24 months month NOUN fnp-4496 33 25 . . PUNCT fnp-4496 34 1 the the DET fnp-4496 34 2 mechanism mechanism NOUN fnp-4496 34 3 of of ADP fnp-4496 34 4 deaths death NOUN fnp-4496 34 5 were be AUX fnp-4496 34 6 : : PUNCT fnp-4496 34 7 suspected suspect VERB fnp-4496 34 8 abusive abusive ADJ fnp-4496 34 9 trauma trauma NOUN fnp-4496 34 10 35 35 NUM fnp-4496 34 11 ; ; PUNCT fnp-4496 34 12 accident accident NOUN fnp-4496 34 13 13 13 NUM fnp-4496 34 14 ; ; PUNCT fnp-4496 34 15 undetermined undetermined ADJ fnp-4496 34 16 or or CCONJ fnp-4496 34 17 natural natural ADJ fnp-4496 34 18 without without ADP fnp-4496 34 19 head head NOUN fnp-4496 34 20 / / SYM fnp-4496 34 21 neck neck NOUN fnp-4496 34 22 trauma trauma NOUN fnp-4496 34 23 12 12 NUM fnp-4496 34 24 ; ; PUNCT fnp-4496 34 25 forceps forceps NOUN fnp-4496 34 26 injury injury NOUN fnp-4496 34 27 at at ADP fnp-4496 34 28 birth birth NOUN fnp-4496 34 29 3 3 NUM fnp-4496 34 30 ; ; PUNCT fnp-4496 34 31 birth birth NOUN fnp-4496 34 32 related relate VERB fnp-4496 34 33 intracranial intracranial ADJ fnp-4496 34 34 hemorrhage hemorrhage NOUN fnp-4496 34 35 7 7 NUM fnp-4496 34 36 . . PUNCT fnp-4496 35 1 prominent prominent ADJ fnp-4496 35 2 spinal spinal NOUN fnp-4496 35 3 subarachnoid subarachnoid VERB fnp-4496 35 4 hemorrhage hemorrhage NOUN fnp-4496 35 5 was be AUX fnp-4496 35 6 present present ADJ fnp-4496 35 7 in in ADP fnp-4496 35 8 30 30 NUM fnp-4496 35 9 cases case NOUN fnp-4496 35 10 ; ; PUNCT fnp-4496 35 11 hemorrhage hemorrhage NOUN fnp-4496 35 12 was be AUX fnp-4496 35 13 detected detect VERB fnp-4496 35 14 along along ADP fnp-4496 35 15 spinal spinal NOUN fnp-4496 35 16 nerve nerve NOUN fnp-4496 35 17 roots root NOUN fnp-4496 35 18 at at ADP fnp-4496 35 19 the the DET fnp-4496 35 20 cervical cervical ADJ fnp-4496 35 21 level level NOUN fnp-4496 35 22 in in ADP fnp-4496 35 23 14/30 14/30 NUM fnp-4496 35 24 and and CCONJ fnp-4496 35 25 at at ADP fnp-4496 35 26 the the DET fnp-4496 35 27 lumbosacral lumbosacral ADJ fnp-4496 35 28 level level NOUN fnp-4496 35 29 in in ADP fnp-4496 35 30 8/30 8/30 NUM fnp-4496 35 31 in in ADP fnp-4496 35 32 the the DET fnp-4496 35 33 absence absence NOUN fnp-4496 35 34 of of ADP fnp-4496 35 35 definite definite ADJ fnp-4496 35 36 injury injury NOUN fnp-4496 35 37 to to ADP fnp-4496 35 38 the the DET fnp-4496 35 39 spinal spinal ADJ fnp-4496 35 40 column column NOUN fnp-4496 35 41 . . PUNCT fnp-4496 36 1 two two NUM fnp-4496 36 2 cases case NOUN fnp-4496 36 3 with with ADP fnp-4496 36 4 definite definite ADJ fnp-4496 36 5 evidence evidence NOUN fnp-4496 36 6 of of ADP fnp-4496 36 7 bone bone NOUN fnp-4496 36 8 / / SYM fnp-4496 36 9 ligamentous ligamentous ADJ fnp-4496 36 10 injury injury NOUN fnp-4496 36 11 to to ADP fnp-4496 36 12 the the DET fnp-4496 36 13 spine spine NOUN fnp-4496 36 14 and and CCONJ fnp-4496 36 15 the the DET fnp-4496 36 16 2 2 NUM fnp-4496 36 17 forceps forceps NOUN fnp-4496 36 18 injury injury NOUN fnp-4496 36 19 cases case NOUN fnp-4496 36 20 had have VERB fnp-4496 36 21 extensive extensive ADJ fnp-4496 36 22 epidural epidural ADJ fnp-4496 36 23 hemorrhage hemorrhage NOUN fnp-4496 36 24 ± ± NOUN fnp-4496 36 25 subarachnoid subarachnoid VERB fnp-4496 36 26 hemorrhage hemorrhage NOUN fnp-4496 36 27 extending extend VERB fnp-4496 36 28 the the DET fnp-4496 36 29 entire entire ADJ fnp-4496 36 30 length length NOUN fnp-4496 36 31 of of ADP fnp-4496 36 32 the the DET fnp-4496 36 33 cord cord NOUN fnp-4496 36 34 . . PUNCT fnp-4496 37 1 anatomical anatomical ADJ fnp-4496 37 2 studies study NOUN fnp-4496 37 3 in in ADP fnp-4496 37 4 humans human NOUN fnp-4496 37 5 , , PUNCT fnp-4496 37 6 tracer tracer NOUN fnp-4496 37 7 studies study NOUN fnp-4496 37 8 , , PUNCT fnp-4496 37 9 and and CCONJ fnp-4496 37 10 experimental experimental ADJ fnp-4496 37 11 hemorrhage hemorrhage NOUN fnp-4496 37 12 show show VERB fnp-4496 37 13 direct direct ADJ fnp-4496 37 14 communication communication NOUN fnp-4496 37 15 of of ADP fnp-4496 37 16 the the DET fnp-4496 37 17 cranial cranial NOUN fnp-4496 37 18 and and CCONJ fnp-4496 37 19 spinal spinal ADJ fnp-4496 37 20 subarachnoid subarachnoid NOUN fnp-4496 37 21 and and CCONJ fnp-4496 37 22 subdural subdural ADJ fnp-4496 37 23 spaces space NOUN fnp-4496 37 24 with with ADP fnp-4496 37 25 extension extension NOUN fnp-4496 37 26 to to ADP fnp-4496 37 27 the the DET fnp-4496 37 28 dorsal dorsal NOUN fnp-4496 37 29 root root NOUN fnp-4496 37 30 ganglia ganglia NOUN fnp-4496 37 31 . . PUNCT fnp-4496 38 1 i i PRON fnp-4496 38 2 conclude conclude VERB fnp-4496 38 3 that that SCONJ fnp-4496 38 4 the the DET fnp-4496 38 5 majority majority NOUN fnp-4496 38 6 of of ADP fnp-4496 38 7 spinal spinal ADJ fnp-4496 38 8 nerve nerve NOUN fnp-4496 38 9 root root NOUN fnp-4496 38 10 hemorrhages hemorrhage NOUN fnp-4496 38 11 in in ADP fnp-4496 38 12 pediatric pediatric ADJ fnp-4496 38 13 trauma trauma NOUN fnp-4496 38 14 cases case NOUN fnp-4496 38 15 are be AUX fnp-4496 38 16 simply simply ADV fnp-4496 38 17 markers marker NOUN fnp-4496 38 18 of of ADP fnp-4496 38 19 subarachnoid subarachnoid NOUN fnp-4496 38 20 or or CCONJ fnp-4496 38 21 subdural subdural ADJ fnp-4496 38 22 hemorrhage hemorrhage NOUN fnp-4496 38 23 elsewhere elsewhere ADV fnp-4496 38 24 . . PUNCT fnp-4496 39 1 additional additional ADJ fnp-4496 39 2 work work NOUN fnp-4496 39 3 is be AUX fnp-4496 39 4 needed need VERB fnp-4496 39 5 to to PART fnp-4496 39 6 determine determine VERB fnp-4496 39 7 if if SCONJ fnp-4496 39 8 en en PROPN fnp-4496 39 9 bloc bloc PROPN fnp-4496 39 10 spine spine ADJ fnp-4496 39 11 dissection dissection NOUN fnp-4496 39 12 , , PUNCT fnp-4496 39 13 which which PRON fnp-4496 39 14 is be AUX fnp-4496 39 15 invasive invasive ADJ fnp-4496 39 16 and and CCONJ fnp-4496 39 17 time time NOUN fnp-4496 39 18 consuming consume VERB fnp-4496 39 19 , , PUNCT fnp-4496 39 20 adds add VERB fnp-4496 39 21 significant significant ADJ fnp-4496 39 22 information information NOUN fnp-4496 39 23 to to ADP fnp-4496 39 24 the the DET fnp-4496 39 25 autopsy autopsy NOUN fnp-4496 39 26 . . PUNCT fnp-4496 39 27     SPACE fnp-4496 40 1 abstract abstract ADJ fnp-4496 40 2 4 4 NUM fnp-4496 40 3 free free ADJ fnp-4496 40 4 neuropathol neuropathol NOUN fnp-4496 40 5 3:25:7 3:25:7 NUM fnp-4496 40 6 multifocal multifocal ADJ fnp-4496 40 7 necrotizing necrotizing NOUN fnp-4496 40 8 leukoencephalopathy leukoencephalopathy ADJ fnp-4496 40 9 post post ADJ fnp-4496 40 10 - - ADJ fnp-4496 40 11 covid-19 covid-19 ADJ fnp-4496 40 12 infection infection NOUN fnp-4496 40 13 : : PUNCT fnp-4496 40 14 expanding expand VERB fnp-4496 40 15 the the DET fnp-4496 40 16 “ " PUNCT fnp-4496 40 17 neuro neuro PROPN fnp-4496 40 18 - - PUNCT fnp-4496 40 19 covid covid NOUN fnp-4496 40 20 ” " PUNCT fnp-4496 40 21 spectrum spectrum PROPN fnp-4496 40 22 jacob jacob PROPN fnp-4496 40 23 a. a. PROPN fnp-4496 40 24 houpt1 houpt1 PROPN fnp-4496 40 25 , , PUNCT fnp-4496 40 26 lee lee PROPN fnp-4496 40 27 cyn cyn PROPN fnp-4496 40 28 ang1,2 ang1,2 PROPN fnp-4496 40 29 , , PUNCT fnp-4496 40 30 qi qi PROPN fnp-4496 40 31 zhang1,2 zhang1,2 PROPN fnp-4496 40 32 1 1 NUM fnp-4496 40 33 department department NOUN fnp-4496 40 34 of of ADP fnp-4496 40 35 pathology pathology NOUN fnp-4496 40 36 and and CCONJ fnp-4496 40 37 laboratory laboratory NOUN fnp-4496 40 38 medicine medicine NOUN fnp-4496 40 39 , , PUNCT fnp-4496 40 40 london london PROPN fnp-4496 40 41 health health PROPN fnp-4496 40 42 sciences sciences PROPN fnp-4496 40 43 centre centre PROPN fnp-4496 40 44 , , PUNCT fnp-4496 40 45 london london PROPN fnp-4496 40 46 , , PUNCT fnp-4496 40 47 ontario ontario PROPN fnp-4496 40 48 , , PUNCT fnp-4496 40 49 canada canada PROPN fnp-4496 40 50 2 2 NUM fnp-4496 40 51 department department NOUN fnp-4496 40 52 of of ADP fnp-4496 40 53 clinical clinical ADJ fnp-4496 40 54 neurological neurological ADJ fnp-4496 40 55 sciences science NOUN fnp-4496 40 56 , , PUNCT fnp-4496 40 57 london london PROPN fnp-4496 40 58 health health PROPN fnp-4496 40 59 sciences sciences PROPN fnp-4496 40 60 centre centre PROPN fnp-4496 40 61 , , PUNCT fnp-4496 40 62 london london PROPN fnp-4496 40 63 , , PUNCT fnp-4496 40 64 ontario ontario PROPN fnp-4496 40 65 , , PUNCT fnp-4496 40 66 canada canada PROPN fnp-4496 40 67 multifocal multifocal ADJ fnp-4496 40 68 necrotizing necrotizing NOUN fnp-4496 40 69 leukoencephalopathy leukoencephalopathy NOUN fnp-4496 40 70 ( ( PUNCT fnp-4496 40 71 mnl mnl NOUN fnp-4496 40 72 ) ) PUNCT fnp-4496 40 73 , , PUNCT fnp-4496 40 74 also also ADV fnp-4496 40 75 known know VERB fnp-4496 40 76 as as ADP fnp-4496 40 77 disseminated disseminate VERB fnp-4496 40 78 necrotizing necrotizing NOUN fnp-4496 40 79 leukoencephalopathy leukoencephalopathy NOUN fnp-4496 40 80 ( ( PUNCT fnp-4496 40 81 dnl dnl PROPN fnp-4496 40 82 ) ) PUNCT fnp-4496 40 83 , , PUNCT fnp-4496 40 84 is be AUX fnp-4496 40 85 a a DET fnp-4496 40 86 rare rare ADJ fnp-4496 40 87 pathological pathological ADJ fnp-4496 40 88 phenomenon phenomenon NOUN fnp-4496 40 89 defined define VERB fnp-4496 40 90 by by ADP fnp-4496 40 91 numerous numerous ADJ fnp-4496 40 92 discrete discrete ADJ fnp-4496 40 93 foci focus NOUN fnp-4496 40 94 of of ADP fnp-4496 40 95 necrosis necrosis NOUN fnp-4496 40 96 with with ADP fnp-4496 40 97 predilection predilection NOUN fnp-4496 40 98 for for ADP fnp-4496 40 99 ventral ventral ADJ fnp-4496 40 100 pontine pontine ADJ fnp-4496 40 101 white white ADJ fnp-4496 40 102 matter matter NOUN fnp-4496 40 103 . . PUNCT fnp-4496 41 1 while while SCONJ fnp-4496 41 2 exact exact ADJ fnp-4496 41 3 etiology etiology NOUN fnp-4496 41 4 and and CCONJ fnp-4496 41 5 pathogenic pathogenic ADJ fnp-4496 41 6 mechanisms mechanism NOUN fnp-4496 41 7 have have VERB fnp-4496 41 8 yet yet ADV fnp-4496 41 9 to to PART fnp-4496 41 10 be be AUX fnp-4496 41 11 elucidated elucidate VERB fnp-4496 41 12 , , PUNCT fnp-4496 41 13 mnl mnl PROPN fnp-4496 41 14 is be AUX fnp-4496 41 15 most most ADV fnp-4496 41 16 often often ADV fnp-4496 41 17 reported report VERB fnp-4496 41 18 on on ADP fnp-4496 41 19 post post ADJ fnp-4496 41 20 - - ADJ fnp-4496 41 21 mortem mortem ADJ fnp-4496 41 22 examination examination NOUN fnp-4496 41 23 in in ADP fnp-4496 41 24 the the DET fnp-4496 41 25 context context NOUN fnp-4496 41 26 of of ADP fnp-4496 41 27 immunocompromised immunocompromise VERB fnp-4496 41 28 ( ( PUNCT fnp-4496 41 29 ex ex NOUN fnp-4496 41 30 : : PUNCT fnp-4496 41 31 receiving receive VERB fnp-4496 41 32 chemotherapy chemotherapy NOUN fnp-4496 41 33 or or CCONJ fnp-4496 41 34 with with ADP fnp-4496 41 35 untreated untreated ADJ fnp-4496 41 36 hiv hiv PROPN fnp-4496 41 37 - - PUNCT fnp-4496 41 38 aids aids PROPN fnp-4496 41 39 ) ) PUNCT fnp-4496 41 40 or or CCONJ fnp-4496 41 41 critically critically ADV fnp-4496 41 42 ill ill ADJ fnp-4496 41 43 patients patient NOUN fnp-4496 41 44 ( ( PUNCT fnp-4496 41 45 ex ex NOUN fnp-4496 41 46 : : PUNCT fnp-4496 41 47 metastatic metastatic ADJ fnp-4496 41 48 cancer cancer NOUN fnp-4496 41 49 , , PUNCT fnp-4496 41 50 sepsis sepsis NOUN fnp-4496 41 51 ) ) PUNCT fnp-4496 41 52 . . PUNCT fnp-4496 42 1 coronavirus coronavirus NOUN fnp-4496 42 2 disease disease NOUN fnp-4496 42 3 2019 2019 NUM fnp-4496 42 4 ( ( PUNCT fnp-4496 42 5 covid-19 covid-19 PROPN fnp-4496 42 6 ) ) PUNCT fnp-4496 42 7 is be AUX fnp-4496 42 8 a a DET fnp-4496 42 9 viral viral ADJ fnp-4496 42 10 respiratory respiratory ADJ fnp-4496 42 11 illness illness NOUN fnp-4496 42 12 with with ADP fnp-4496 42 13 variable variable ADJ fnp-4496 42 14 severity severity NOUN fnp-4496 42 15 depending depend VERB fnp-4496 42 16 on on ADP fnp-4496 42 17 host host NOUN fnp-4496 42 18 immune immune ADJ fnp-4496 42 19 response response NOUN fnp-4496 42 20 and and CCONJ fnp-4496 42 21 comorbid comorbid NOUN fnp-4496 42 22 conditions condition NOUN fnp-4496 42 23 . . PUNCT fnp-4496 43 1 in in ADP fnp-4496 43 2 its its PRON fnp-4496 43 3 most most ADV fnp-4496 43 4 serious serious ADJ fnp-4496 43 5 cases case NOUN fnp-4496 43 6 , , PUNCT fnp-4496 43 7 covid-19 covid-19 PROPN fnp-4496 43 8 can can AUX fnp-4496 43 9 elicit elicit VERB fnp-4496 43 10 both both PRON fnp-4496 43 11 harmfully harmfully ADV fnp-4496 43 12 insufficient insufficient ADJ fnp-4496 43 13 and and CCONJ fnp-4496 43 14 excessive excessive ADJ fnp-4496 43 15 immune immune ADJ fnp-4496 43 16 responses response NOUN fnp-4496 43 17 . . PUNCT fnp-4496 44 1 we we PRON fnp-4496 44 2 report report VERB fnp-4496 44 3 on on ADP fnp-4496 44 4 a a DET fnp-4496 44 5 case case NOUN fnp-4496 44 6 of of ADP fnp-4496 44 7 covid-19 covid-19 PROPN fnp-4496 44 8 pneumonia pneumonia NOUN fnp-4496 44 9 which which PRON fnp-4496 44 10 progressed progress VERB fnp-4496 44 11 to to ADP fnp-4496 44 12 a a DET fnp-4496 44 13 clinical clinical ADJ fnp-4496 44 14 impression impression NOUN fnp-4496 44 15 of of ADP fnp-4496 44 16 sepsis sepsis NOUN fnp-4496 44 17 , , PUNCT fnp-4496 44 18 declining decline VERB fnp-4496 44 19 respiratory respiratory ADJ fnp-4496 44 20 status status NOUN fnp-4496 44 21 , , PUNCT fnp-4496 44 22 and and CCONJ fnp-4496 44 23 death death NOUN fnp-4496 44 24 in in ADP fnp-4496 44 25 an an DET fnp-4496 44 26 unvaccinated unvaccinate VERB fnp-4496 44 27 , , PUNCT fnp-4496 44 28 previously previously ADV fnp-4496 44 29 well well ADV fnp-4496 44 30 patient patient ADJ fnp-4496 44 31 in in ADP fnp-4496 44 32 which which PRON fnp-4496 44 33 there there PRON fnp-4496 44 34 were be VERB fnp-4496 44 35 findings finding NOUN fnp-4496 44 36 consistent consistent ADJ fnp-4496 44 37 with with ADP fnp-4496 44 38 mnl mnl PROPN fnp-4496 44 39 throughout throughout ADP fnp-4496 44 40 the the DET fnp-4496 44 41 midbrain midbrain NOUN fnp-4496 44 42 and and CCONJ fnp-4496 44 43 basis basis NOUN fnp-4496 44 44 pontis pontis NOUN fnp-4496 44 45 . . PUNCT fnp-4496 45 1 there there PRON fnp-4496 45 2 was be VERB fnp-4496 45 3 no no DET fnp-4496 45 4 encephalitis encephalitis NOUN fnp-4496 45 5 , , PUNCT fnp-4496 45 6 microthrombi microthrombi NOUN fnp-4496 45 7 , , PUNCT fnp-4496 45 8 infarcts infarct VERB fnp-4496 45 9 , , PUNCT fnp-4496 45 10 or or CCONJ fnp-4496 45 11 other other ADJ fnp-4496 45 12 previously previously ADV fnp-4496 45 13 reported report VERB fnp-4496 45 14 neuropathological neuropathological ADJ fnp-4496 45 15 findings finding NOUN fnp-4496 45 16 . . PUNCT fnp-4496 46 1 this this DET fnp-4496 46 2 index index NOUN fnp-4496 46 3 case case NOUN fnp-4496 46 4 was be AUX fnp-4496 46 5 again again ADV fnp-4496 46 6 compared compare VERB fnp-4496 46 7 and and CCONJ fnp-4496 46 8 contrasted contrast VERB fnp-4496 46 9 against against ADP fnp-4496 46 10 four four NUM fnp-4496 46 11 additional additional ADJ fnp-4496 46 12 mnl mnl NOUN fnp-4496 46 13 cases case NOUN fnp-4496 46 14 examined examine VERB fnp-4496 46 15 at at ADP fnp-4496 46 16 the the DET fnp-4496 46 17 london london PROPN fnp-4496 46 18 health health PROPN fnp-4496 46 19 sciences sciences PROPN fnp-4496 46 20 centre centre NOUN fnp-4496 46 21 . . PUNCT fnp-4496 47 1 the the DET fnp-4496 47 2 neuropathological neuropathological ADJ fnp-4496 47 3 findings finding NOUN fnp-4496 47 4 are be AUX fnp-4496 47 5 examined examine VERB fnp-4496 47 6 and and CCONJ fnp-4496 47 7 described describe VERB fnp-4496 47 8 for for ADP fnp-4496 47 9 these these DET fnp-4496 47 10 5 5 NUM fnp-4496 47 11 cases case NOUN fnp-4496 47 12 , , PUNCT fnp-4496 47 13 all all ADV fnp-4496 47 14 with with ADP fnp-4496 47 15 clinical clinical ADJ fnp-4496 47 16 scenarios scenario NOUN fnp-4496 47 17 involving involve VERB fnp-4496 47 18 systemic systemic ADJ fnp-4496 47 19 critical critical ADJ fnp-4496 47 20 illness illness NOUN fnp-4496 47 21 and/or and/or CCONJ fnp-4496 47 22 immune immune ADJ fnp-4496 47 23 system system NOUN fnp-4496 47 24 compromise compromise NOUN fnp-4496 47 25 and and CCONJ fnp-4496 47 26 with with ADP fnp-4496 47 27 similar similar ADJ fnp-4496 47 28 ventral ventral ADJ fnp-4496 47 29 pontine pontine ADJ fnp-4496 47 30 focal focal ADJ fnp-4496 47 31 necrosis necrosis NOUN fnp-4496 47 32 , , PUNCT fnp-4496 47 33 myelin myelin NOUN fnp-4496 47 34 loss loss NOUN fnp-4496 47 35 , , PUNCT fnp-4496 47 36 and and CCONJ fnp-4496 47 37 limited limited ADJ fnp-4496 47 38 reactive reactive ADJ fnp-4496 47 39 glial glial ADJ fnp-4496 47 40 response response NOUN fnp-4496 47 41 . . PUNCT fnp-4496 48 1 though though SCONJ fnp-4496 48 2 numerous numerous ADJ fnp-4496 48 3 radiological radiological ADJ fnp-4496 48 4 studies study NOUN fnp-4496 48 5 have have AUX fnp-4496 48 6 suggested suggest VERB fnp-4496 48 7 a a DET fnp-4496 48 8 disseminated disseminate VERB fnp-4496 48 9 necrotizing necrotize VERB fnp-4496 48 10 leukoencephalopathic leukoencephalopathic ADJ fnp-4496 48 11 process process NOUN fnp-4496 48 12 underlying underlie VERB fnp-4496 48 13 covid-19 covid-19 PROPN fnp-4496 48 14 - - PUNCT fnp-4496 48 15 associated associate VERB fnp-4496 48 16 encephalopathy encephalopathy NOUN fnp-4496 48 17 , , PUNCT fnp-4496 48 18 this this DET fnp-4496 48 19 case case NOUN fnp-4496 48 20 represents represent VERB fnp-4496 48 21 the the DET fnp-4496 48 22 first first ADJ fnp-4496 48 23 to to PART fnp-4496 48 24 offer offer VERB fnp-4496 48 25 pathological pathological ADJ fnp-4496 48 26 correlation correlation NOUN fnp-4496 48 27 supported support VERB fnp-4496 48 28 by by ADP fnp-4496 48 29 autopsy autopsy ADJ fnp-4496 48 30 confirmation confirmation NOUN fnp-4496 48 31 of of ADP fnp-4496 48 32 mnl mnl PROPN fnp-4496 48 33 in in ADP fnp-4496 48 34 a a DET fnp-4496 48 35 patient patient NOUN fnp-4496 48 36 with with ADP fnp-4496 48 37 covid-19 covid-19 PROPN fnp-4496 48 38 infection infection NOUN fnp-4496 48 39 . . PUNCT fnp-4496 48 40     SPACE fnp-4496 49 1 abstract abstract ADJ fnp-4496 49 2 5 5 NUM fnp-4496 49 3 free free ADJ fnp-4496 49 4 neuropathol neuropathol NOUN fnp-4496 49 5 3:25:8 3:25:8 NUM fnp-4496 49 6 the the DET fnp-4496 49 7 international international ADJ fnp-4496 49 8 disseminated disseminate VERB fnp-4496 49 9 pediatric pediatric ADJ fnp-4496 49 10 low low ADJ fnp-4496 49 11 grade grade NOUN fnp-4496 49 12 glioma glioma NOUN fnp-4496 49 13 consortium consortium NOUN fnp-4496 49 14 : : PUNCT fnp-4496 49 15 project project NOUN fnp-4496 49 16 goals goal NOUN fnp-4496 49 17 and and CCONJ fnp-4496 49 18 preliminary preliminary ADJ fnp-4496 49 19 results result NOUN fnp-4496 49 20 adrian adrian PROPN fnp-4496 49 21 levine1,4 levine1,4 PROPN fnp-4496 49 22 , , PUNCT fnp-4496 49 23 julie julie PROPN fnp-4496 49 24 bennett2 bennett2 PROPN fnp-4496 49 25 , , PUNCT fnp-4496 49 26 joseline joseline VERB fnp-4496 49 27 haizel haizel ADJ fnp-4496 49 28 - - PUNCT fnp-4496 49 29 cobbina3 cobbina3 NOUN fnp-4496 49 30 , , PUNCT fnp-4496 49 31 liana liana NOUN fnp-4496 49 32 nobre2 nobre2 PROPN fnp-4496 49 33 , , PUNCT fnp-4496 49 34 michael michael PROPN fnp-4496 49 35 dewan3 dewan3 PROPN fnp-4496 49 36 , , PUNCT fnp-4496 49 37 uri uri PROPN fnp-4496 49 38 tabori2 tabori2 PROPN fnp-4496 49 39 , , PUNCT fnp-4496 49 40 cynthia cynthia PROPN fnp-4496 49 41 hawkins1 hawkins1 PROPN fnp-4496 49 42 1 1 NUM fnp-4496 49 43 department department NOUN fnp-4496 49 44 of of ADP fnp-4496 49 45 pediatric pediatric ADJ fnp-4496 49 46 laboratory laboratory NOUN fnp-4496 49 47 medicine medicine NOUN fnp-4496 49 48 , , PUNCT fnp-4496 49 49 hospital hospital NOUN fnp-4496 49 50 for for ADP fnp-4496 49 51 sick sick ADJ fnp-4496 49 52 children child NOUN fnp-4496 49 53 , , PUNCT fnp-4496 49 54 toronto toronto PROPN fnp-4496 49 55 , , PUNCT fnp-4496 49 56 on on ADP fnp-4496 49 57 , , PUNCT fnp-4496 49 58 canada canada PROPN fnp-4496 49 59 2 2 NUM fnp-4496 49 60 division division NOUN fnp-4496 49 61 of of ADP fnp-4496 49 62 neuro neuro NOUN fnp-4496 49 63 - - PUNCT fnp-4496 49 64 oncology oncology NOUN fnp-4496 49 65 , , PUNCT fnp-4496 49 66 hospital hospital NOUN fnp-4496 49 67 for for ADP fnp-4496 49 68 sick sick ADJ fnp-4496 49 69 children child NOUN fnp-4496 49 70 , , PUNCT fnp-4496 49 71 toronto toronto PROPN fnp-4496 49 72 , , PUNCT fnp-4496 49 73 on on ADP fnp-4496 49 74 , , PUNCT fnp-4496 49 75 canada canada PROPN fnp-4496 49 76 3 3 NUM fnp-4496 49 77 department department NOUN fnp-4496 49 78 of of ADP fnp-4496 49 79 neurosurgery neurosurgery NOUN fnp-4496 49 80 , , PUNCT fnp-4496 49 81 vanderbilt vanderbilt PROPN fnp-4496 49 82 university university PROPN fnp-4496 49 83 medical medical ADJ fnp-4496 49 84 center center NOUN fnp-4496 49 85 , , PUNCT fnp-4496 49 86 nashville nashville PROPN fnp-4496 49 87 , , PUNCT fnp-4496 49 88 tn tn PROPN fnp-4496 49 89 , , PUNCT fnp-4496 49 90 usa usa PROPN fnp-4496 49 91 4 4 NUM fnp-4496 49 92 clinician clinician NOUN fnp-4496 49 93 investigator investigator NOUN fnp-4496 49 94 program program NOUN fnp-4496 49 95 , , PUNCT fnp-4496 49 96 university university NOUN fnp-4496 49 97 of of ADP fnp-4496 49 98 british british PROPN fnp-4496 49 99 columbia columbia PROPN fnp-4496 49 100 , , PUNCT fnp-4496 49 101 bc bc PROPN fnp-4496 49 102 , , PUNCT fnp-4496 49 103 canada canada PROPN fnp-4496 49 104 although although SCONJ fnp-4496 49 105 most most ADJ fnp-4496 49 106 pediatric pediatric ADJ fnp-4496 49 107 lgg lgg NOUN fnp-4496 49 108 ( ( PUNCT fnp-4496 49 109 plgg plgg NUM fnp-4496 49 110 ) ) PUNCT fnp-4496 49 111 have have VERB fnp-4496 49 112 excellent excellent ADJ fnp-4496 49 113 long long ADJ fnp-4496 49 114 - - PUNCT fnp-4496 49 115 term term NOUN fnp-4496 49 116 survival survival NOUN fnp-4496 49 117 , , PUNCT fnp-4496 49 118 there there PRON fnp-4496 49 119 is be VERB fnp-4496 49 120 a a DET fnp-4496 49 121 subset subset NOUN fnp-4496 49 122 of of ADP fnp-4496 49 123 cases case NOUN fnp-4496 49 124 that that PRON fnp-4496 49 125 disseminate disseminate VERB fnp-4496 49 126 ( ( PUNCT fnp-4496 49 127 dplgg dplgg NOUN fnp-4496 49 128 ) ) PUNCT fnp-4496 49 129 and and CCONJ fnp-4496 49 130 have have VERB fnp-4496 49 131 very very ADV fnp-4496 49 132 poor poor ADJ fnp-4496 49 133 outcomes outcome NOUN fnp-4496 49 134 . . PUNCT fnp-4496 50 1 it it PRON fnp-4496 50 2 is be AUX fnp-4496 50 3 unknown unknown ADJ fnp-4496 50 4 why why SCONJ fnp-4496 50 5 these these DET fnp-4496 50 6 tumors tumor NOUN fnp-4496 50 7 behave behave VERB fnp-4496 50 8 in in ADP fnp-4496 50 9 such such DET fnp-4496 50 10 an an DET fnp-4496 50 11 aggressive aggressive ADJ fnp-4496 50 12 way way NOUN fnp-4496 50 13 . . PUNCT fnp-4496 51 1 we we PRON fnp-4496 51 2 believe believe VERB fnp-4496 51 3 that that SCONJ fnp-4496 51 4 biological biological ADJ fnp-4496 51 5 mechanisms mechanism NOUN fnp-4496 51 6 , , PUNCT fnp-4496 51 7 distinct distinct ADJ fnp-4496 51 8 from from ADP fnp-4496 51 9 those those PRON fnp-4496 51 10 present present ADJ fnp-4496 51 11 in in ADP fnp-4496 51 12 non non ADJ fnp-4496 51 13 - - ADJ fnp-4496 51 14 disseminated disseminate VERB fnp-4496 51 15 lgg lgg VERB fnp-4496 51 16 , , PUNCT fnp-4496 51 17 underlie underlie VERB fnp-4496 51 18 this this DET fnp-4496 51 19 metastatic metastatic ADJ fnp-4496 51 20 ability ability NOUN fnp-4496 51 21 , , PUNCT fnp-4496 51 22 but but CCONJ fnp-4496 51 23 so so ADV fnp-4496 51 24 far far ADV fnp-4496 51 25 there there PRON fnp-4496 51 26 has have AUX fnp-4496 51 27 been be AUX fnp-4496 51 28 no no DET fnp-4496 51 29 in in ADP fnp-4496 51 30 - - PUNCT fnp-4496 51 31 depth depth NOUN fnp-4496 51 32 investigation investigation NOUN fnp-4496 51 33 of of ADP fnp-4496 51 34 this this PRON fnp-4496 51 35 . . PUNCT fnp-4496 52 1 to to PART fnp-4496 52 2 improve improve VERB fnp-4496 52 3 our our PRON fnp-4496 52 4 understanding understanding NOUN fnp-4496 52 5 of of ADP fnp-4496 52 6 this this DET fnp-4496 52 7 rare rare ADJ fnp-4496 52 8 patient patient ADJ fnp-4496 52 9 population population NOUN fnp-4496 52 10 , , PUNCT fnp-4496 52 11 we we PRON fnp-4496 52 12 have have AUX fnp-4496 52 13 created create VERB fnp-4496 52 14 a a DET fnp-4496 52 15 new new ADJ fnp-4496 52 16 consortium consortium NOUN fnp-4496 52 17 to to PART fnp-4496 52 18 compile compile VERB fnp-4496 52 19 dlgg dlgg NOUN fnp-4496 52 20 cases case NOUN fnp-4496 52 21 across across ADP fnp-4496 52 22 from from ADP fnp-4496 52 23 across across ADP fnp-4496 52 24 the the DET fnp-4496 52 25 world world NOUN fnp-4496 52 26 . . PUNCT fnp-4496 53 1 we we PRON fnp-4496 53 2 are be AUX fnp-4496 53 3 collecting collect VERB fnp-4496 53 4 comprehensive comprehensive ADJ fnp-4496 53 5 clinical clinical ADJ fnp-4496 53 6 information information NOUN fnp-4496 53 7 , , PUNCT fnp-4496 53 8 including include VERB fnp-4496 53 9 the the DET fnp-4496 53 10 tumor tumor NOUN fnp-4496 53 11 presentation presentation NOUN fnp-4496 53 12 and and CCONJ fnp-4496 53 13 pattern pattern NOUN fnp-4496 53 14 of of ADP fnp-4496 53 15 dissemination dissemination NOUN fnp-4496 53 16 , , PUNCT fnp-4496 53 17 surgical surgical ADJ fnp-4496 53 18 outcomes outcome NOUN fnp-4496 53 19 and and CCONJ fnp-4496 53 20 subsequent subsequent ADJ fnp-4496 53 21 treatment treatment NOUN fnp-4496 53 22 courses course NOUN fnp-4496 53 23 , , PUNCT fnp-4496 53 24 and and CCONJ fnp-4496 53 25 quality quality NOUN fnp-4496 53 26 of of ADP fnp-4496 53 27 life life NOUN fnp-4496 53 28 outcomes outcome NOUN fnp-4496 53 29 . . PUNCT fnp-4496 54 1 cases case NOUN fnp-4496 54 2 with with ADP fnp-4496 54 3 available available ADJ fnp-4496 54 4 tissue tissue NOUN fnp-4496 54 5 will will AUX fnp-4496 54 6 be be AUX fnp-4496 54 7 tested test VERB fnp-4496 54 8 with with ADP fnp-4496 54 9 our our PRON fnp-4496 54 10 glioma glioma NOUN fnp-4496 54 11 ngs ng NOUN fnp-4496 54 12 panel panel NOUN fnp-4496 54 13 for for ADP fnp-4496 54 14 the the DET fnp-4496 54 15 most most ADV fnp-4496 54 16 common common ADJ fnp-4496 54 17 mutations mutation NOUN fnp-4496 54 18 and and CCONJ fnp-4496 54 19 fusions fusion NOUN fnp-4496 54 20 , , PUNCT fnp-4496 54 21 and and CCONJ fnp-4496 54 22 methylation methylation NOUN fnp-4496 54 23 array array NOUN fnp-4496 54 24 for for ADP fnp-4496 54 25 copy copy NOUN fnp-4496 54 26 number number NOUN fnp-4496 54 27 and and CCONJ fnp-4496 54 28 classification classification NOUN fnp-4496 54 29 . . PUNCT fnp-4496 55 1 our our PRON fnp-4496 55 2 data datum NOUN fnp-4496 55 3 thus thus ADV fnp-4496 55 4 far far ADV fnp-4496 55 5 on on ADP fnp-4496 55 6 the the DET fnp-4496 55 7 first first ADJ fnp-4496 55 8 53 53 NUM fnp-4496 55 9 cases case NOUN fnp-4496 55 10 demonstrates demonstrate VERB fnp-4496 55 11 the the DET fnp-4496 55 12 dplgg dplgg NOUN fnp-4496 55 13 has have VERB fnp-4496 55 14 much much ADV fnp-4496 55 15 worse bad ADJ fnp-4496 55 16 prognosis prognosis NOUN fnp-4496 55 17 than than ADP fnp-4496 55 18 the the DET fnp-4496 55 19 overall overall ADJ fnp-4496 55 20 plgg plgg NOUN fnp-4496 55 21 population population NOUN fnp-4496 55 22 . . PUNCT fnp-4496 56 1 virtually virtually ADV fnp-4496 56 2 all all DET fnp-4496 56 3 dplgg dplgg ADJ fnp-4496 56 4 progress progress NOUN fnp-4496 56 5 at at ADP fnp-4496 56 6 5 5 NUM fnp-4496 56 7 years year NOUN fnp-4496 56 8 , , PUNCT fnp-4496 56 9 compared compare VERB fnp-4496 56 10 to to ADP fnp-4496 56 11 a a DET fnp-4496 56 12 quarter quarter NOUN fnp-4496 56 13 of of ADP fnp-4496 56 14 other other ADJ fnp-4496 56 15 plgg plgg NOUN fnp-4496 56 16 , , PUNCT fnp-4496 56 17 and and CCONJ fnp-4496 56 18 the the DET fnp-4496 56 19 disseminated disseminate VERB fnp-4496 56 20 cases case NOUN fnp-4496 56 21 are be AUX fnp-4496 56 22 approximately approximately ADV fnp-4496 56 23 5 5 NUM fnp-4496 56 24 - - PUNCT fnp-4496 56 25 times time NOUN fnp-4496 56 26 more more ADV fnp-4496 56 27 likely likely ADJ fnp-4496 56 28 to to PART fnp-4496 56 29 die die VERB fnp-4496 56 30 at at ADP fnp-4496 56 31 10 10 NUM fnp-4496 56 32 years year NOUN fnp-4496 56 33 . . PUNCT fnp-4496 57 1 this this PRON fnp-4496 57 2 can can AUX fnp-4496 57 3 affect affect VERB fnp-4496 57 4 children child NOUN fnp-4496 57 5 of of ADP fnp-4496 57 6 all all DET fnp-4496 57 7 ages age NOUN fnp-4496 57 8 and and CCONJ fnp-4496 57 9 does do AUX fnp-4496 57 10 not not PART fnp-4496 57 11 carry carry VERB fnp-4496 57 12 a a DET fnp-4496 57 13 gender gender NOUN fnp-4496 57 14 predilection predilection NOUN fnp-4496 57 15 . . PUNCT fnp-4496 58 1 we we PRON fnp-4496 58 2 observe observe VERB fnp-4496 58 3 three three NUM fnp-4496 58 4 patterns pattern NOUN fnp-4496 58 5 of of ADP fnp-4496 58 6 dissemination dissemination NOUN fnp-4496 58 7 – – PUNCT fnp-4496 58 8 40 40 NUM fnp-4496 58 9 % % NOUN fnp-4496 58 10 of of ADP fnp-4496 58 11 patients patient NOUN fnp-4496 58 12 present present ADJ fnp-4496 58 13 with with ADP fnp-4496 58 14 a a DET fnp-4496 58 15 localized localize VERB fnp-4496 58 16 mass mass NOUN fnp-4496 58 17 and and CCONJ fnp-4496 58 18 have have VERB fnp-4496 58 19 secondary secondary ADJ fnp-4496 58 20 dissemination dissemination NOUN fnp-4496 58 21 , , PUNCT fnp-4496 58 22 35 35 NUM fnp-4496 58 23 % % NOUN fnp-4496 58 24 with with ADP fnp-4496 58 25 disseminated disseminate VERB fnp-4496 58 26 tumor tumor NOUN fnp-4496 58 27 and and CCONJ fnp-4496 58 28 a a DET fnp-4496 58 29 clear clear ADJ fnp-4496 58 30 dominant dominant ADJ fnp-4496 58 31 mass mass NOUN fnp-4496 58 32 , , PUNCT fnp-4496 58 33 and and CCONJ fnp-4496 58 34 25 25 NUM fnp-4496 58 35 % % NOUN fnp-4496 58 36 with with ADP fnp-4496 58 37 disseminated disseminate VERB fnp-4496 58 38 disease disease NOUN fnp-4496 58 39 without without ADP fnp-4496 58 40 a a DET fnp-4496 58 41 dominant dominant ADJ fnp-4496 58 42 mass mass NOUN fnp-4496 58 43 . . PUNCT fnp-4496 59 1 the the DET fnp-4496 59 2 most most ADV fnp-4496 59 3 common common ADJ fnp-4496 59 4 molecular molecular ADJ fnp-4496 59 5 alteration alteration NOUN fnp-4496 59 6 is be AUX fnp-4496 59 7 braf braf NOUN fnp-4496 59 8 fusions fusion NOUN fnp-4496 59 9 . . PUNCT fnp-4496 59 10     SPACE fnp-4496 60 1 abstract abstract ADJ fnp-4496 60 2 6 6 NUM fnp-4496 60 3 free free ADJ fnp-4496 60 4 neuropathol neuropathol NOUN fnp-4496 60 5 3:25:9 3:25:9 NUM fnp-4496 60 6 glioblastoma glioblastoma NOUN fnp-4496 60 7 , , PUNCT fnp-4496 60 8 idh idh NOUN fnp-4496 60 9 - - PUNCT fnp-4496 60 10 wildtype wildtype NOUN fnp-4496 60 11 with with ADP fnp-4496 60 12 fgfr3 fgfr3 PROPN fnp-4496 60 13 - - PUNCT fnp-4496 60 14 tacc3 tacc3 NOUN fnp-4496 60 15 fusion fusion NOUN fnp-4496 60 16 has have VERB fnp-4496 60 17 unusual unusual ADJ fnp-4496 60 18 histologic histologic ADJ fnp-4496 60 19 , , PUNCT fnp-4496 60 20 molecular molecular ADJ fnp-4496 60 21 and and CCONJ fnp-4496 60 22 clinicoradiologic clinicoradiologic ADJ fnp-4496 60 23 characteristics characteristic NOUN fnp-4496 60 24 namita namita PROPN fnp-4496 60 25 sinha1 sinha1 PROPN fnp-4496 60 26 , , PUNCT fnp-4496 60 27 sherry sherry PROPN fnp-4496 60 28 krawitz1 krawitz1 PROPN fnp-4496 60 29 , , PUNCT fnp-4496 60 30 jai jai PROPN fnp-4496 60 31 j.s j.s PROPN fnp-4496 60 32 . . PUNCT fnp-4496 61 1 shankar2 shankar2 PROPN fnp-4496 61 2 , , PUNCT fnp-4496 61 3 saranya saranya PROPN fnp-4496 61 4 kakumanu3 kakumanu3 PROPN fnp-4496 61 5 , , PUNCT fnp-4496 61 6 ken ken PROPN fnp-4496 61 7 aldape4 aldape4 PROPN fnp-4496 61 8 , , PUNCT fnp-4496 61 9 marc marc PROPN fnp-4496 61 10 r.del r.del PROPN fnp-4496 61 11 bigio1 bigio1 PROPN fnp-4496 61 12 1 1 NUM fnp-4496 61 13 department department NOUN fnp-4496 61 14 of of ADP fnp-4496 61 15 pathology pathology PROPN fnp-4496 61 16 , , PUNCT fnp-4496 61 17 university university PROPN fnp-4496 61 18 of of ADP fnp-4496 61 19 manitoba manitoba PROPN fnp-4496 61 20 , , PUNCT fnp-4496 61 21 winnipeg winnipeg PROPN fnp-4496 61 22 , , PUNCT fnp-4496 61 23 mb mb PROPN fnp-4496 61 24 , , PUNCT fnp-4496 61 25 canada canada PROPN fnp-4496 61 26 2 2 NUM fnp-4496 61 27 department department NOUN fnp-4496 61 28 of of ADP fnp-4496 61 29 radiology radiology NOUN fnp-4496 61 30 , , PUNCT fnp-4496 61 31 university university PROPN fnp-4496 61 32 of of ADP fnp-4496 61 33 manitoba manitoba PROPN fnp-4496 61 34 , , PUNCT fnp-4496 61 35 winnipeg winnipeg PROPN fnp-4496 61 36 , , PUNCT fnp-4496 61 37 mb mb PROPN fnp-4496 61 38 , , PUNCT fnp-4496 61 39 canada canada PROPN fnp-4496 61 40 3 3 NUM fnp-4496 61 41 cancer cancer PROPN fnp-4496 61 42 care care PROPN fnp-4496 61 43 manitoba manitoba PROPN fnp-4496 61 44 , , PUNCT fnp-4496 61 45 university university PROPN fnp-4496 61 46 of of ADP fnp-4496 61 47 manitoba manitoba PROPN fnp-4496 61 48 , , PUNCT fnp-4496 61 49 winnipeg winnipeg PROPN fnp-4496 61 50 , , PUNCT fnp-4496 61 51 mb mb PROPN fnp-4496 61 52 , , PUNCT fnp-4496 61 53 canada canada PROPN fnp-4496 61 54 4 4 NUM fnp-4496 61 55 laboratory laboratory NOUN fnp-4496 61 56 of of ADP fnp-4496 61 57 pathology pathology PROPN fnp-4496 61 58 , , PUNCT fnp-4496 61 59 national national PROPN fnp-4496 61 60 cancer cancer PROPN fnp-4496 61 61 institute institute PROPN fnp-4496 61 62 , , PUNCT fnp-4496 61 63 nih nih PROPN fnp-4496 61 64 , , PUNCT fnp-4496 61 65 bethesda bethesda PROPN fnp-4496 61 66 , , PUNCT fnp-4496 61 67 maryland maryland PROPN fnp-4496 61 68 , , PUNCT fnp-4496 61 69 usa usa PROPN fnp-4496 61 70 according accord VERB fnp-4496 61 71 to to ADP fnp-4496 61 72 2021 2021 NUM fnp-4496 61 73 world world NOUN fnp-4496 61 74 health health NOUN fnp-4496 61 75 organization organization NOUN fnp-4496 61 76 ( ( PUNCT fnp-4496 61 77 who who PRON fnp-4496 61 78 ) ) PUNCT fnp-4496 61 79 classification classification NOUN fnp-4496 61 80 , , PUNCT fnp-4496 61 81 term term NOUN fnp-4496 61 82 ‘ ' PUNCT fnp-4496 61 83 glioblastoma glioblastoma NOUN fnp-4496 61 84 ’ ' PUNCT fnp-4496 61 85 is be AUX fnp-4496 61 86 reserved reserve VERB fnp-4496 61 87 for for ADP fnp-4496 61 88 cns cns PROPN fnp-4496 61 89 who who PRON fnp-4496 61 90 grade grade VERB fnp-4496 61 91 4 4 NUM fnp-4496 61 92 astrocytic astrocytic ADJ fnp-4496 61 93 neoplasm neoplasm NOUN fnp-4496 61 94 that that PRON fnp-4496 61 95 is be AUX fnp-4496 61 96 idh idh NOUN fnp-4496 61 97 - - PUNCT fnp-4496 61 98 wildtype wildtype NOUN fnp-4496 61 99 . . PUNCT fnp-4496 62 1 a a DET fnp-4496 62 2 small small ADJ fnp-4496 62 3 subset subset NOUN fnp-4496 62 4 of of ADP fnp-4496 62 5 glioblastomas glioblastoma NOUN fnp-4496 62 6 may may AUX fnp-4496 62 7 have have VERB fnp-4496 62 8 unusual unusual ADJ fnp-4496 62 9 clinical clinical ADJ fnp-4496 62 10 , , PUNCT fnp-4496 62 11 histological histological ADJ fnp-4496 62 12 and and CCONJ fnp-4496 62 13 molecular molecular ADJ fnp-4496 62 14 profiles profile NOUN fnp-4496 62 15 that that PRON fnp-4496 62 16 may may AUX fnp-4496 62 17 need need VERB fnp-4496 62 18 appropriate appropriate ADJ fnp-4496 62 19 molecular molecular ADJ fnp-4496 62 20 work work NOUN fnp-4496 62 21 - - PUNCT fnp-4496 62 22 up up NOUN fnp-4496 62 23 for for ADP fnp-4496 62 24 definitive definitive ADJ fnp-4496 62 25 diagnosis diagnosis NOUN fnp-4496 62 26 , , PUNCT fnp-4496 62 27 and and CCONJ fnp-4496 62 28 some some PRON fnp-4496 62 29 of of ADP fnp-4496 62 30 them they PRON fnp-4496 62 31 may may AUX fnp-4496 62 32 be be AUX fnp-4496 62 33 reported report VERB fnp-4496 62 34 as as ADP fnp-4496 62 35 high high ADJ fnp-4496 62 36 - - PUNCT fnp-4496 62 37 grade grade NOUN fnp-4496 62 38 glioma glioma NOUN fnp-4496 62 39 , , PUNCT fnp-4496 62 40 not not PART fnp-4496 62 41 otherwise otherwise ADV fnp-4496 62 42 specified specify VERB fnp-4496 62 43 , , PUNCT fnp-4496 62 44 if if SCONJ fnp-4496 62 45 complete complete ADJ fnp-4496 62 46 molecular molecular ADJ fnp-4496 62 47 work work NOUN fnp-4496 62 48 up up ADP fnp-4496 62 49 is be AUX fnp-4496 62 50 lacking lack VERB fnp-4496 62 51 . . PUNCT fnp-4496 63 1 we we PRON fnp-4496 63 2 present present VERB fnp-4496 63 3 two two NUM fnp-4496 63 4 cases case NOUN fnp-4496 63 5 : : PUNCT fnp-4496 63 6 a a DET fnp-4496 63 7 48 48 NUM fnp-4496 63 8 - - PUNCT fnp-4496 63 9 year year NOUN fnp-4496 63 10 - - PUNCT fnp-4496 63 11 old old ADJ fnp-4496 63 12 female female NOUN fnp-4496 63 13 with with ADP fnp-4496 63 14 imaging imaging NOUN fnp-4496 63 15 revealing reveal VERB fnp-4496 63 16 right right ADJ fnp-4496 63 17 occipital occipital NOUN fnp-4496 63 18 solid solid ADJ fnp-4496 63 19 , , PUNCT fnp-4496 63 20 cystic cystic ADJ fnp-4496 63 21 , , PUNCT fnp-4496 63 22 mass mass ADJ fnp-4496 63 23 demonstrating demonstrate VERB fnp-4496 63 24 nodular nodular ADJ fnp-4496 63 25 calcification calcification NOUN fnp-4496 63 26 ; ; PUNCT fnp-4496 63 27 and and CCONJ fnp-4496 63 28 a a DET fnp-4496 63 29 53 53 NUM fnp-4496 63 30 - - PUNCT fnp-4496 63 31 year year NOUN fnp-4496 63 32 - - PUNCT fnp-4496 63 33 old old ADJ fnp-4496 63 34 male male NOUN fnp-4496 63 35 with with ADP fnp-4496 63 36 imaging imaging NOUN fnp-4496 63 37 revealing reveal VERB fnp-4496 63 38 multifocal multifocal ADJ fnp-4496 63 39 enhancing enhance VERB fnp-4496 63 40 mass mass NOUN fnp-4496 63 41 with with ADP fnp-4496 63 42 extensive extensive ADJ fnp-4496 63 43 calcification calcification NOUN fnp-4496 63 44 in in ADP fnp-4496 63 45 the the DET fnp-4496 63 46 right right NOUN fnp-4496 63 47 parietal parietal ADJ fnp-4496 63 48 , , PUNCT fnp-4496 63 49 occipital occipital ADJ fnp-4496 63 50 and and CCONJ fnp-4496 63 51 temporal temporal ADJ fnp-4496 63 52 regions region NOUN fnp-4496 63 53 . . PUNCT fnp-4496 64 1 the the DET fnp-4496 64 2 cerebral cerebral ADJ fnp-4496 64 3 tumors tumor NOUN fnp-4496 64 4 in in ADP fnp-4496 64 5 both both DET fnp-4496 64 6 patients patient NOUN fnp-4496 64 7 were be AUX fnp-4496 64 8 relatively relatively ADV fnp-4496 64 9 circumscribed circumscribed ADJ fnp-4496 64 10 high high ADJ fnp-4496 64 11 - - PUNCT fnp-4496 64 12 grade grade NOUN fnp-4496 64 13 glioma glioma NOUN fnp-4496 64 14 composed compose VERB fnp-4496 64 15 of of ADP fnp-4496 64 16 gfap gfap ADJ fnp-4496 64 17 immunoreactive immunoreactive ADJ fnp-4496 64 18 monomorphic monomorphic ADJ fnp-4496 64 19 ovoid ovoid ADJ fnp-4496 64 20 cells cell NOUN fnp-4496 64 21 , , PUNCT fnp-4496 64 22 with with ADP fnp-4496 64 23 endothelial endothelial ADJ fnp-4496 64 24 proliferation proliferation NOUN fnp-4496 64 25 , , PUNCT fnp-4496 64 26 predominantly predominantly ADV fnp-4496 64 27 infarct infarct ADJ fnp-4496 64 28 - - PUNCT fnp-4496 64 29 type type NOUN fnp-4496 64 30 necrosis necrosis NOUN fnp-4496 64 31 , , PUNCT fnp-4496 64 32 and and CCONJ fnp-4496 64 33 abundant abundant ADJ fnp-4496 64 34 calcospherites calcospherite NOUN fnp-4496 64 35 . . PUNCT fnp-4496 65 1 both both DET fnp-4496 65 2 tumors tumor NOUN fnp-4496 65 3 showed show VERB fnp-4496 65 4 occasional occasional ADJ fnp-4496 65 5 mitosis mitosis NOUN fnp-4496 65 6 with with ADP fnp-4496 65 7 ki-67 ki-67 NUM fnp-4496 65 8 of of ADP fnp-4496 65 9 ~ ~ PUNCT fnp-4496 65 10 5 5 NUM fnp-4496 65 11 - - SYM fnp-4496 65 12 10 10 NUM fnp-4496 65 13 % % NOUN fnp-4496 65 14 . . PUNCT fnp-4496 66 1 mass mass PROPN fnp-4496 66 2 array array PROPN fnp-4496 66 3 analysis analysis NOUN fnp-4496 66 4 showed show VERB fnp-4496 66 5 no no DET fnp-4496 66 6 idh idh NOUN fnp-4496 66 7 , , PUNCT fnp-4496 66 8 h3f3a h3f3a NUM fnp-4496 66 9 , , PUNCT fnp-4496 66 10 braf braf NOUN fnp-4496 66 11 v600e v600e NOUN fnp-4496 66 12 mutation mutation NOUN fnp-4496 66 13 in in ADP fnp-4496 66 14 these these DET fnp-4496 66 15 two two NUM fnp-4496 66 16 cases case NOUN fnp-4496 66 17 and and CCONJ fnp-4496 66 18 revealed reveal VERB fnp-4496 66 19 tert tert NOUN fnp-4496 66 20 promoter promoter NOUN fnp-4496 66 21 mutation mutation NOUN fnp-4496 66 22 in in ADP fnp-4496 66 23 the the DET fnp-4496 66 24 second second ADJ fnp-4496 66 25 case case NOUN fnp-4496 66 26 . . PUNCT fnp-4496 67 1 because because SCONJ fnp-4496 67 2 of of ADP fnp-4496 67 3 unusual unusual ADJ fnp-4496 67 4 histology histology NOUN fnp-4496 67 5 , , PUNCT fnp-4496 67 6 methylation methylation NOUN fnp-4496 67 7 profiling profiling NOUN fnp-4496 67 8 was be AUX fnp-4496 67 9 pursued pursue VERB fnp-4496 67 10 in in ADP fnp-4496 67 11 these these DET fnp-4496 67 12 two two NUM fnp-4496 67 13 cases case NOUN fnp-4496 67 14 that that PRON fnp-4496 67 15 matched match VERB fnp-4496 67 16 to to ADP fnp-4496 67 17 glioblastoma glioblastoma NOUN fnp-4496 67 18 . . PUNCT fnp-4496 68 1 interestingly interestingly ADV fnp-4496 68 2 , , PUNCT fnp-4496 68 3 ngs ng NOUN fnp-4496 68 4 study study NOUN fnp-4496 68 5 showed show VERB fnp-4496 68 6 fgfr3 fgfr3 PROPN fnp-4496 68 7 - - PUNCT fnp-4496 68 8 tacc3 tacc3 NOUN fnp-4496 68 9 fusion fusion NOUN fnp-4496 68 10 in in ADP fnp-4496 68 11 both both CCONJ fnp-4496 68 12 the the DET fnp-4496 68 13 cases case NOUN fnp-4496 68 14 . . PUNCT fnp-4496 69 1 follow follow VERB fnp-4496 69 2 - - PUNCT fnp-4496 69 3 up up ADP fnp-4496 69 4 imaging imaging NOUN fnp-4496 69 5 showed show VERB fnp-4496 69 6 tumor tumor NOUN fnp-4496 69 7 progression progression NOUN fnp-4496 69 8 in in ADP fnp-4496 69 9 these these DET fnp-4496 69 10 two two NUM fnp-4496 69 11 patients patient NOUN fnp-4496 69 12 , , PUNCT fnp-4496 69 13 with with ADP fnp-4496 69 14 recurrence recurrence NOUN fnp-4496 69 15 at at ADP fnp-4496 69 16 9 9 NUM fnp-4496 69 17 months month NOUN fnp-4496 69 18 in in ADP fnp-4496 69 19 the the DET fnp-4496 69 20 second second ADJ fnp-4496 69 21 patient patient NOUN fnp-4496 69 22 . . PUNCT fnp-4496 70 1 both both CCONJ fnp-4496 70 2 the the DET fnp-4496 70 3 patients patient NOUN fnp-4496 70 4 are be AUX fnp-4496 70 5 clinically clinically ADV fnp-4496 70 6 well well ADJ fnp-4496 70 7 at at ADP fnp-4496 70 8 7 7 NUM fnp-4496 70 9 months month NOUN fnp-4496 70 10 and and CCONJ fnp-4496 70 11 15 15 NUM fnp-4496 70 12 months month NOUN fnp-4496 70 13 of of ADP fnp-4496 70 14 follow follow NOUN fnp-4496 70 15 - - PUNCT fnp-4496 70 16 up up NOUN fnp-4496 70 17 . . PUNCT fnp-4496 71 1 a a DET fnp-4496 71 2 few few ADJ fnp-4496 71 3 case case NOUN fnp-4496 71 4 reports report NOUN fnp-4496 71 5 are be AUX fnp-4496 71 6 published publish VERB fnp-4496 71 7 with with ADP fnp-4496 71 8 similar similar ADJ fnp-4496 71 9 histologic histologic ADJ fnp-4496 71 10 and and CCONJ fnp-4496 71 11 molecular molecular ADJ fnp-4496 71 12 findings finding NOUN fnp-4496 71 13 . . PUNCT fnp-4496 72 1 our our PRON fnp-4496 72 2 cases case NOUN fnp-4496 72 3 contribute contribute VERB fnp-4496 72 4 to to ADP fnp-4496 72 5 expanding expand VERB fnp-4496 72 6 histologic histologic NOUN fnp-4496 72 7 , , PUNCT fnp-4496 72 8 molecular molecular ADJ fnp-4496 72 9 and and CCONJ fnp-4496 72 10 clinical clinical ADJ fnp-4496 72 11 spectrum spectrum NOUN fnp-4496 72 12 of of ADP fnp-4496 72 13 fgfr3 fgfr3 PROPN fnp-4496 72 14 - - PUNCT fnp-4496 72 15 tacc3 tacc3 NOUN fnp-4496 72 16 fused fuse VERB fnp-4496 72 17 glioblastoma glioblastoma NOUN fnp-4496 72 18 . . PUNCT fnp-4496 72 19     SPACE fnp-4496 73 1 abstract abstract ADJ fnp-4496 73 2 7 7 NUM fnp-4496 73 3 free free ADJ fnp-4496 73 4 neuropathol neuropathol NOUN fnp-4496 73 5 3:25:10 3:25:10 NUM fnp-4496 73 6 infiltrative infiltrative ADJ fnp-4496 73 7 pattern pattern NOUN fnp-4496 73 8 in in ADP fnp-4496 73 9 pediatric pediatric ADJ fnp-4496 73 10 ganglioglioma ganglioglioma ADJ fnp-4496 73 11 murad murad NOUN fnp-4496 73 12 alturkustani1 alturkustani1 PROPN fnp-4496 73 13 1 1 NUM fnp-4496 73 14 department department NOUN fnp-4496 73 15 of of ADP fnp-4496 73 16 pathology pathology PROPN fnp-4496 73 17 , , PUNCT fnp-4496 73 18 faculty faculty NOUN fnp-4496 73 19 of of ADP fnp-4496 73 20 medicine medicine NOUN fnp-4496 73 21 , , PUNCT fnp-4496 73 22 king king PROPN fnp-4496 73 23 abdulaziz abdulaziz PROPN fnp-4496 73 24 university university PROPN fnp-4496 73 25 , , PUNCT fnp-4496 73 26 jeddah jeddah PROPN fnp-4496 73 27 , , PUNCT fnp-4496 73 28 saudi saudi PROPN fnp-4496 73 29 arabia arabia PROPN fnp-4496 73 30 ganglioglioma ganglioglioma NOUN fnp-4496 73 31 is be AUX fnp-4496 73 32 a a DET fnp-4496 73 33 well well ADV fnp-4496 73 34 - - PUNCT fnp-4496 73 35 circumscribed circumscribe VERB fnp-4496 73 36 low low ADJ fnp-4496 73 37 - - PUNCT fnp-4496 73 38 grade grade NOUN fnp-4496 73 39 glioneuronal glioneuronal ADJ fnp-4496 73 40 tumor tumor NOUN fnp-4496 73 41 with with ADP fnp-4496 73 42 a a DET fnp-4496 73 43 broad broad ADJ fnp-4496 73 44 morphological morphological ADJ fnp-4496 73 45 spectrum spectrum NOUN fnp-4496 73 46 . . PUNCT fnp-4496 74 1 diffuse diffuse ADJ fnp-4496 74 2 glioneuronal glioneuronal ADJ fnp-4496 74 3 tumors tumor NOUN fnp-4496 74 4 are be AUX fnp-4496 74 5 used use VERB fnp-4496 74 6 to to PART fnp-4496 74 7 describe describe VERB fnp-4496 74 8 cases case NOUN fnp-4496 74 9 with with ADP fnp-4496 74 10 infiltrative infiltrative ADJ fnp-4496 74 11 growth growth NOUN fnp-4496 74 12 . . PUNCT fnp-4496 75 1 molecular molecular ADJ fnp-4496 75 2 studies study NOUN fnp-4496 75 3 of of ADP fnp-4496 75 4 some some PRON fnp-4496 75 5 of of ADP fnp-4496 75 6 these these DET fnp-4496 75 7 cases case NOUN fnp-4496 75 8 were be AUX fnp-4496 75 9 consistent consistent ADJ fnp-4496 75 10 with with ADP fnp-4496 75 11 ganglioglioma ganglioglioma NOUN fnp-4496 75 12 . . PUNCT fnp-4496 76 1 this this DET fnp-4496 76 2 work work NOUN fnp-4496 76 3 aims aim VERB fnp-4496 76 4 to to PART fnp-4496 76 5 clarify clarify VERB fnp-4496 76 6 the the DET fnp-4496 76 7 growth growth NOUN fnp-4496 76 8 patterns pattern NOUN fnp-4496 76 9 in in ADP fnp-4496 76 10 ganglioglioma ganglioglioma NOUN fnp-4496 76 11 . . PUNCT fnp-4496 77 1 the the DET fnp-4496 77 2 available available ADJ fnp-4496 77 3 slides slide NOUN fnp-4496 77 4 and and CCONJ fnp-4496 77 5 clinical clinical ADJ fnp-4496 77 6 and and CCONJ fnp-4496 77 7 molecular molecular ADJ fnp-4496 77 8 information information NOUN fnp-4496 77 9 for for ADP fnp-4496 77 10 ganglioglioma ganglioglioma ADJ fnp-4496 77 11 cases case NOUN fnp-4496 77 12 under under ADP fnp-4496 77 13 the the DET fnp-4496 77 14 open open ADJ fnp-4496 77 15 pediatric pediatric ADJ fnp-4496 77 16 brain brain NOUN fnp-4496 77 17 tumor tumor NOUN fnp-4496 77 18 atlas atlas PROPN fnp-4496 77 19 from from ADP fnp-4496 77 20 the the DET fnp-4496 77 21 children child NOUN fnp-4496 77 22 ’s ’s PART fnp-4496 77 23 brain brain NOUN fnp-4496 77 24 tumor tumor NOUN fnp-4496 77 25 network network NOUN fnp-4496 77 26 database database NOUN fnp-4496 77 27 were be AUX fnp-4496 77 28 reviewed review VERB fnp-4496 77 29 to to PART fnp-4496 77 30 confirm confirm VERB fnp-4496 77 31 the the DET fnp-4496 77 32 integrated integrate VERB fnp-4496 77 33 diagnosis diagnosis NOUN fnp-4496 77 34 and and CCONJ fnp-4496 77 35 to to PART fnp-4496 77 36 evaluate evaluate VERB fnp-4496 77 37 the the DET fnp-4496 77 38 growth growth NOUN fnp-4496 77 39 patterns pattern NOUN fnp-4496 77 40 in in ADP fnp-4496 77 41 these these DET fnp-4496 77 42 cases case NOUN fnp-4496 77 43 . . PUNCT fnp-4496 78 1 infiltration infiltration NOUN fnp-4496 78 2 is be AUX fnp-4496 78 3 defined define VERB fnp-4496 78 4 as as ADP fnp-4496 78 5 the the DET fnp-4496 78 6 presence presence NOUN fnp-4496 78 7 of of ADP fnp-4496 78 8 neoplastic neoplastic ADJ fnp-4496 78 9 cells cell NOUN fnp-4496 78 10 among among ADP fnp-4496 78 11 the the DET fnp-4496 78 12 nonneoplastic nonneoplastic ADJ fnp-4496 78 13 parenchyma parenchyma NOUN fnp-4496 78 14 . . PUNCT fnp-4496 79 1 the the DET fnp-4496 79 2 diagnosis diagnosis NOUN fnp-4496 79 3 of of ADP fnp-4496 79 4 ganglioglioma ganglioglioma NOUN fnp-4496 79 5 was be AUX fnp-4496 79 6 confirmed confirm VERB fnp-4496 79 7 in in ADP fnp-4496 79 8 16 16 NUM fnp-4496 79 9 of of ADP fnp-4496 79 10 46 46 NUM fnp-4496 79 11 cases case NOUN fnp-4496 79 12 ( ( PUNCT fnp-4496 79 13 nine nine NUM fnp-4496 79 14 females female NOUN fnp-4496 79 15 and and CCONJ fnp-4496 79 16 seven seven NUM fnp-4496 79 17 males male NOUN fnp-4496 79 18 ; ; PUNCT fnp-4496 79 19 age age NOUN fnp-4496 79 20 ranges range VERB fnp-4496 79 21 from from ADP fnp-4496 79 22 eight eight NUM fnp-4496 79 23 months month NOUN fnp-4496 79 24 – – PUNCT fnp-4496 79 25 19 19 NUM fnp-4496 79 26 years year NOUN fnp-4496 79 27 with with ADP fnp-4496 79 28 a a DET fnp-4496 79 29 mean mean NOUN fnp-4496 79 30 of of ADP fnp-4496 79 31 9.9 9.9 NUM fnp-4496 79 32 years year NOUN fnp-4496 79 33 ) ) PUNCT fnp-4496 79 34 . . PUNCT fnp-4496 80 1 the the DET fnp-4496 80 2 infiltrative infiltrative ADJ fnp-4496 80 3 pattern pattern NOUN fnp-4496 80 4 was be AUX fnp-4496 80 5 identified identify VERB fnp-4496 80 6 in in ADP fnp-4496 80 7 5 5 NUM fnp-4496 80 8 cases case NOUN fnp-4496 80 9 as as ADP fnp-4496 80 10 the the DET fnp-4496 80 11 predominant predominant ADJ fnp-4496 80 12 pattern pattern NOUN fnp-4496 80 13 and and CCONJ fnp-4496 80 14 in in ADP fnp-4496 80 15 another another DET fnp-4496 80 16 5 5 NUM fnp-4496 80 17 cases case NOUN fnp-4496 80 18 combined combine VERB fnp-4496 80 19 with with ADP fnp-4496 80 20 a a DET fnp-4496 80 21 circumscribed circumscribed ADJ fnp-4496 80 22 nodule nodule NOUN fnp-4496 80 23 , , PUNCT fnp-4496 80 24 while while SCONJ fnp-4496 80 25 only only ADV fnp-4496 80 26 6 6 NUM fnp-4496 80 27 cases case NOUN fnp-4496 80 28 had have VERB fnp-4496 80 29 predominant predominant ADJ fnp-4496 80 30 circumscribed circumscribed ADJ fnp-4496 80 31 growth growth NOUN fnp-4496 80 32 . . PUNCT fnp-4496 81 1 this this DET fnp-4496 81 2 work work NOUN fnp-4496 81 3 confirms confirm VERB fnp-4496 81 4 the the DET fnp-4496 81 5 presence presence NOUN fnp-4496 81 6 of of ADP fnp-4496 81 7 an an DET fnp-4496 81 8 infiltrative infiltrative ADJ fnp-4496 81 9 / / SYM fnp-4496 81 10 diffuse diffuse NOUN fnp-4496 81 11 variant variant NOUN fnp-4496 81 12 of of ADP fnp-4496 81 13 ganglioglioma ganglioglioma NOUN fnp-4496 81 14 . . PUNCT fnp-4496 82 1 awareness awareness NOUN fnp-4496 82 2 of of ADP fnp-4496 82 3 this this DET fnp-4496 82 4 variant variant NOUN fnp-4496 82 5 should should AUX fnp-4496 82 6 help help VERB fnp-4496 82 7 with with ADP fnp-4496 82 8 infiltrative infiltrative ADJ fnp-4496 82 9 tumors tumor NOUN fnp-4496 82 10 , , PUNCT fnp-4496 82 11 as as SCONJ fnp-4496 82 12 the the DET fnp-4496 82 13 differential differential NOUN fnp-4496 82 14 includes include VERB fnp-4496 82 15 diffuse diffuse NOUN fnp-4496 82 16 glioma glioma NOUN fnp-4496 82 17 , , PUNCT fnp-4496 82 18 which which PRON fnp-4496 82 19 is be AUX fnp-4496 82 20 usually usually ADV fnp-4496 82 21 idh idh VERB fnp-4496 82 22 wild wild ADJ fnp-4496 82 23 type type NOUN fnp-4496 82 24 in in ADP fnp-4496 82 25 this this DET fnp-4496 82 26 population population NOUN fnp-4496 82 27 . . PUNCT fnp-4496 82 28     SPACE fnp-4496 83 1 abstract abstract ADJ fnp-4496 83 2 8 8 NUM fnp-4496 83 3 free free ADJ fnp-4496 83 4 neuropathol neuropathol NOUN fnp-4496 83 5 3:25:11 3:25:11 NUM fnp-4496 83 6 clinical clinical ADJ fnp-4496 83 7 implementation implementation NOUN fnp-4496 83 8 of of ADP fnp-4496 83 9 methylation methylation NOUN fnp-4496 83 10 profiling profiling NOUN fnp-4496 83 11 : : PUNCT fnp-4496 83 12 the the DET fnp-4496 83 13 sickkids sickkids PROPN fnp-4496 83 14 experience experience PROPN fnp-4496 83 15 adrian adrian PROPN fnp-4496 83 16 levine1,2 levine1,2 PROPN fnp-4496 83 17 , , PUNCT fnp-4496 83 18 michelle michelle PROPN fnp-4496 83 19 ku1 ku1 PROPN fnp-4496 83 20 , , PUNCT fnp-4496 83 21 scott scott PROPN fnp-4496 83 22 ryall1 ryall1 PROPN fnp-4496 83 23 , , PUNCT fnp-4496 83 24 cynthia cynthia PROPN fnp-4496 83 25 hawkins1 hawkins1 PROPN fnp-4496 83 26 1 1 NUM fnp-4496 83 27 department department NOUN fnp-4496 83 28 of of ADP fnp-4496 83 29 pediatric pediatric ADJ fnp-4496 83 30 laboratory laboratory NOUN fnp-4496 83 31 medicine medicine NOUN fnp-4496 83 32 , , PUNCT fnp-4496 83 33 hospital hospital NOUN fnp-4496 83 34 for for ADP fnp-4496 83 35 sick sick ADJ fnp-4496 83 36 children child NOUN fnp-4496 83 37 , , PUNCT fnp-4496 83 38 toronto toronto PROPN fnp-4496 83 39 , , PUNCT fnp-4496 83 40 on on ADP fnp-4496 83 41 , , PUNCT fnp-4496 83 42 canada canada PROPN fnp-4496 83 43 2 2 NUM fnp-4496 83 44 clinician clinician NOUN fnp-4496 83 45 investigator investigator NOUN fnp-4496 83 46 program program NOUN fnp-4496 83 47 , , PUNCT fnp-4496 83 48 university university NOUN fnp-4496 83 49 of of ADP fnp-4496 83 50 british british PROPN fnp-4496 83 51 columbia columbia PROPN fnp-4496 83 52 , , PUNCT fnp-4496 83 53 bc bc PROPN fnp-4496 83 54 , , PUNCT fnp-4496 83 55 canada canada PROPN fnp-4496 83 56 over over ADP fnp-4496 83 57 the the DET fnp-4496 83 58 past past ADJ fnp-4496 83 59 decade decade NOUN fnp-4496 83 60 , , PUNCT fnp-4496 83 61 methylation methylation NOUN fnp-4496 83 62 profiling profiling NOUN fnp-4496 83 63 and and CCONJ fnp-4496 83 64 machine machine NOUN fnp-4496 83 65 learning learning NOUN fnp-4496 83 66 based base VERB fnp-4496 83 67 classification classification NOUN fnp-4496 83 68 has have AUX fnp-4496 83 69 had have VERB fnp-4496 83 70 a a DET fnp-4496 83 71 major major ADJ fnp-4496 83 72 impact impact NOUN fnp-4496 83 73 on on ADP fnp-4496 83 74 the the DET fnp-4496 83 75 diagnostic diagnostic ADJ fnp-4496 83 76 framework framework NOUN fnp-4496 83 77 for for ADP fnp-4496 83 78 cns cns NOUN fnp-4496 83 79 tumors tumor NOUN fnp-4496 83 80 , , PUNCT fnp-4496 83 81 however however ADV fnp-4496 83 82 there there PRON fnp-4496 83 83 remains remain VERB fnp-4496 83 84 inconsistent inconsistent ADJ fnp-4496 83 85 and and CCONJ fnp-4496 83 86 limited limited ADJ fnp-4496 83 87 access access NOUN fnp-4496 83 88 to to ADP fnp-4496 83 89 clinical clinical ADJ fnp-4496 83 90 testing testing NOUN fnp-4496 83 91 for for ADP fnp-4496 83 92 this this DET fnp-4496 83 93 analysis analysis NOUN fnp-4496 83 94 . . PUNCT fnp-4496 84 1 at at ADP fnp-4496 84 2 sickkids sickkid NOUN fnp-4496 84 3 , , PUNCT fnp-4496 84 4 we we PRON fnp-4496 84 5 have have AUX fnp-4496 84 6 implemented implement VERB fnp-4496 84 7 a a DET fnp-4496 84 8 clinically clinically ADV fnp-4496 84 9 validated validate VERB fnp-4496 84 10 methylation methylation NOUN fnp-4496 84 11 assay assay NOUN fnp-4496 84 12 using use VERB fnp-4496 84 13 the the DET fnp-4496 84 14 illumina illumina PROPN fnp-4496 84 15 epic epic ADJ fnp-4496 84 16 platform platform NOUN fnp-4496 84 17 for for ADP fnp-4496 84 18 the the DET fnp-4496 84 19 heidelberg heidelberg NOUN fnp-4496 84 20 cns cns PROPN fnp-4496 84 21 tumor tumor NOUN fnp-4496 84 22 classifier classifier NOUN fnp-4496 84 23 , , PUNCT fnp-4496 84 24 copy copy VERB fnp-4496 84 25 number number NOUN fnp-4496 84 26 profiling profiling NOUN fnp-4496 84 27 , , PUNCT fnp-4496 84 28 and and CCONJ fnp-4496 84 29 mgmt mgmt PROPN fnp-4496 84 30 promoter promoter NOUN fnp-4496 84 31 methylation methylation NOUN fnp-4496 84 32 status status NOUN fnp-4496 84 33 . . PUNCT fnp-4496 85 1 we we PRON fnp-4496 85 2 have have AUX fnp-4496 85 3 now now ADV fnp-4496 85 4 run run VERB fnp-4496 85 5 136 136 NUM fnp-4496 85 6 samples sample NOUN fnp-4496 85 7 for for ADP fnp-4496 85 8 clinical clinical ADJ fnp-4496 85 9 use use NOUN fnp-4496 85 10 ( ( PUNCT fnp-4496 85 11 plus plus CCONJ fnp-4496 85 12 additional additional ADJ fnp-4496 85 13 samples sample NOUN fnp-4496 85 14 for for ADP fnp-4496 85 15 validation validation NOUN fnp-4496 85 16 ) ) PUNCT fnp-4496 85 17 , , PUNCT fnp-4496 85 18 which which PRON fnp-4496 85 19 have have AUX fnp-4496 85 20 been be AUX fnp-4496 85 21 classified classify VERB fnp-4496 85 22 through through ADP fnp-4496 85 23 both both DET fnp-4496 85 24 v11 v11 NOUN fnp-4496 85 25 and and CCONJ fnp-4496 85 26 v12.5 v12.5 NUM fnp-4496 85 27 of of ADP fnp-4496 85 28 the the DET fnp-4496 85 29 heidelberg heidelberg NOUN fnp-4496 85 30 classifier classifier NOUN fnp-4496 85 31 . . PUNCT fnp-4496 86 1 many many ADJ fnp-4496 86 2 external external ADJ fnp-4496 86 3 samples sample NOUN fnp-4496 86 4 were be AUX fnp-4496 86 5 not not PART fnp-4496 86 6 received receive VERB fnp-4496 86 7 with with ADP fnp-4496 86 8 a a DET fnp-4496 86 9 histologic histologic ADJ fnp-4496 86 10 diagnosis diagnosis NOUN fnp-4496 86 11 , , PUNCT fnp-4496 86 12 those those PRON fnp-4496 86 13 that that PRON fnp-4496 86 14 do do AUX fnp-4496 86 15 have have VERB fnp-4496 86 16 a a DET fnp-4496 86 17 diagnosis diagnosis NOUN fnp-4496 86 18 include include VERB fnp-4496 86 19 34 34 NUM fnp-4496 86 20 low low ADJ fnp-4496 86 21 grade grade NOUN fnp-4496 86 22 gliomas glioma NOUN fnp-4496 86 23 ( ( PUNCT fnp-4496 86 24 lgg lgg PROPN fnp-4496 86 25 ) ) PUNCT fnp-4496 86 26 , , PUNCT fnp-4496 86 27 19 19 NUM fnp-4496 86 28 high high ADJ fnp-4496 86 29 grade grade NOUN fnp-4496 86 30 gliomas glioma NOUN fnp-4496 86 31 ( ( PUNCT fnp-4496 86 32 hgg hgg NOUN fnp-4496 86 33 ) ) PUNCT fnp-4496 86 34 , , PUNCT fnp-4496 86 35 10 10 NUM fnp-4496 86 36 ependymomas ependymoma NOUN fnp-4496 86 37 , , PUNCT fnp-4496 86 38 4 4 NUM fnp-4496 86 39 pineal pineal ADJ fnp-4496 86 40 tumors tumor NOUN fnp-4496 86 41 , , PUNCT fnp-4496 86 42 and and CCONJ fnp-4496 86 43 4 4 NUM fnp-4496 86 44 medulloblastoma medulloblastoma ADJ fnp-4496 86 45 / / SYM fnp-4496 86 46 embryonal embryonal ADJ fnp-4496 86 47 tumor tumor NOUN fnp-4496 86 48 . . PUNCT fnp-4496 87 1 overall overall ADJ fnp-4496 87 2 , , PUNCT fnp-4496 87 3 only only ADV fnp-4496 87 4 34 34 NUM fnp-4496 87 5 samples sample NOUN fnp-4496 87 6 ( ( PUNCT fnp-4496 87 7 25 25 NUM fnp-4496 87 8 % % NOUN fnp-4496 87 9 ) ) PUNCT fnp-4496 87 10 classified classify VERB fnp-4496 87 11 with with ADP fnp-4496 87 12 confidence confidence NOUN fnp-4496 87 13 score score NOUN fnp-4496 87 14 > > X fnp-4496 87 15 0.85 0.85 NUM fnp-4496 87 16 on on ADP fnp-4496 87 17 the the DET fnp-4496 87 18 v11 v11 NOUN fnp-4496 87 19 classifier classifier NOUN fnp-4496 87 20 and and CCONJ fnp-4496 87 21 77 77 NUM fnp-4496 87 22 samples sample NOUN fnp-4496 87 23 ( ( PUNCT fnp-4496 87 24 57 57 NUM fnp-4496 87 25 % % NOUN fnp-4496 87 26 ) ) PUNCT fnp-4496 87 27 on on ADP fnp-4496 87 28 v12.5 v12.5 PROPN fnp-4496 87 29 . . PUNCT fnp-4496 88 1 the the DET fnp-4496 88 2 medulloblastomas medulloblastoma NOUN fnp-4496 88 3 all all PRON fnp-4496 88 4 classified classify VERB fnp-4496 88 5 with with ADP fnp-4496 88 6 high high ADJ fnp-4496 88 7 confidence confidence NOUN fnp-4496 88 8 scores score NOUN fnp-4496 88 9 , , PUNCT fnp-4496 88 10 as as SCONJ fnp-4496 88 11 did do VERB fnp-4496 88 12 7/10 7/10 NUM fnp-4496 88 13 ependymomas ependymoma NOUN fnp-4496 88 14 , , PUNCT fnp-4496 88 15 and and CCONJ fnp-4496 88 16 2/3 2/3 NUM fnp-4496 88 17 papillary papillary ADJ fnp-4496 88 18 tumors tumor NOUN fnp-4496 88 19 of of ADP fnp-4496 88 20 the the DET fnp-4496 88 21 pineal pineal NOUN fnp-4496 88 22 region region NOUN fnp-4496 88 23 . . PUNCT fnp-4496 89 1 9/19 9/19 NUM fnp-4496 89 2 hggs hgg NOUN fnp-4496 89 3 classified classify VERB fnp-4496 89 4 with with ADP fnp-4496 89 5 high high ADJ fnp-4496 89 6 confidence confidence NOUN fnp-4496 89 7 – – PUNCT fnp-4496 89 8 most most ADJ fnp-4496 89 9 of of ADP fnp-4496 89 10 which which PRON fnp-4496 89 11 were be AUX fnp-4496 89 12 methylation methylation NOUN fnp-4496 89 13 - - PUNCT fnp-4496 89 14 defined define VERB fnp-4496 89 15 subtypes subtype NOUN fnp-4496 89 16 of of ADP fnp-4496 89 17 idh idh NOUN fnp-4496 89 18 - - PUNCT fnp-4496 89 19 mutant mutant NOUN fnp-4496 89 20 and and CCONJ fnp-4496 89 21 idh idh NOUN fnp-4496 89 22 - - PUNCT fnp-4496 89 23 wildtype wildtype NOUN fnp-4496 89 24 astrocytomas astrocytoma NOUN fnp-4496 89 25 or or CCONJ fnp-4496 89 26 glioblastomas glioblastoma NOUN fnp-4496 89 27 , , PUNCT fnp-4496 89 28 with with ADP fnp-4496 89 29 unclear unclear ADJ fnp-4496 89 30 clinical clinical ADJ fnp-4496 89 31 significance significance NOUN fnp-4496 89 32 . . PUNCT fnp-4496 90 1 notably notably ADV fnp-4496 90 2 , , PUNCT fnp-4496 90 3 though though SCONJ fnp-4496 90 4 2 2 NUM fnp-4496 90 5 of of ADP fnp-4496 90 6 the the DET fnp-4496 90 7 cases case NOUN fnp-4496 90 8 that that PRON fnp-4496 90 9 were be AUX fnp-4496 90 10 referred refer VERB fnp-4496 90 11 as as ADP fnp-4496 90 12 hgg hgg PROPN fnp-4496 90 13 were be AUX fnp-4496 90 14 in in ADP fnp-4496 90 15 fact fact NOUN fnp-4496 90 16 other other ADJ fnp-4496 90 17 tumor tumor NOUN fnp-4496 90 18 types type NOUN fnp-4496 90 19 , , PUNCT fnp-4496 90 20 one one NUM fnp-4496 90 21 being be AUX fnp-4496 90 22 an an DET fnp-4496 90 23 atrt atrt NOUN fnp-4496 90 24 , , PUNCT fnp-4496 90 25 and and CCONJ fnp-4496 90 26 the the DET fnp-4496 90 27 other other ADJ fnp-4496 90 28 an an DET fnp-4496 90 29 ependymoma ependymoma NOUN fnp-4496 90 30 with with ADP fnp-4496 90 31 zfta zfta NOUN fnp-4496 90 32 - - PUNCT fnp-4496 90 33 fusion fusion NOUN fnp-4496 90 34 . . PUNCT fnp-4496 91 1 the the DET fnp-4496 91 2 classifier classifier NOUN fnp-4496 91 3 had have VERB fnp-4496 91 4 particular particular ADJ fnp-4496 91 5 challenge challenge NOUN fnp-4496 91 6 with with ADP fnp-4496 91 7 lggs lgg NOUN fnp-4496 91 8 , , PUNCT fnp-4496 91 9 of of ADP fnp-4496 91 10 which which PRON fnp-4496 91 11 only only ADV fnp-4496 91 12 17 17 NUM fnp-4496 91 13 ( ( PUNCT fnp-4496 91 14 50 50 NUM fnp-4496 91 15 % % NOUN fnp-4496 91 16 ) ) PUNCT fnp-4496 91 17 classified classify VERB fnp-4496 91 18 with with ADP fnp-4496 91 19 high high ADJ fnp-4496 91 20 confidence confidence NOUN fnp-4496 91 21 , , PUNCT fnp-4496 91 22 including include VERB fnp-4496 91 23 one one NUM fnp-4496 91 24 that that PRON fnp-4496 91 25 was be AUX fnp-4496 91 26 erroneously erroneously ADV fnp-4496 91 27 called call VERB fnp-4496 91 28 “ " PUNCT fnp-4496 91 29 control control NOUN fnp-4496 91 30 tissue tissue NOUN fnp-4496 91 31 , , PUNCT fnp-4496 91 32 reactive reactive ADJ fnp-4496 91 33 tumor tumor NOUN fnp-4496 91 34 microenvironment microenvironment NOUN fnp-4496 91 35 ” " PUNCT fnp-4496 91 36 . . PUNCT fnp-4496 91 37     SPACE fnp-4496 92 1 abstract abstract ADJ fnp-4496 92 2 9 9 NUM fnp-4496 92 3 free free ADJ fnp-4496 92 4 neuropathol neuropathol NOUN fnp-4496 92 5 3:25:12 3:25:12 NUM fnp-4496 92 6 cerebral cerebral ADJ fnp-4496 92 7 amyloidoma amyloidoma NOUN fnp-4496 92 8 : : PUNCT fnp-4496 92 9 pathological pathological ADJ fnp-4496 92 10 findings finding NOUN fnp-4496 92 11 from from ADP fnp-4496 92 12 diagnostic diagnostic ADJ fnp-4496 92 13 biopsy biopsy NOUN fnp-4496 92 14 to to ADP fnp-4496 92 15 autopsy autopsy ADJ fnp-4496 92 16 shervin shervin PROPN fnp-4496 92 17 pejhan1 pejhan1 PROPN fnp-4496 92 18 , , PUNCT fnp-4496 92 19 adrian adrian PROPN fnp-4496 92 20 budhram2 budhram2 PROPN fnp-4496 92 21 , , PUNCT fnp-4496 92 22 joseph joseph PROPN fnp-4496 92 23 megyesi2 megyesi2 PROPN fnp-4496 92 24 , , PUNCT fnp-4496 92 25 lee lee PROPN fnp-4496 92 26 cyn cyn PROPN fnp-4496 92 27 ang1,2 ang1,2 PROPN fnp-4496 92 28 , , PUNCT fnp-4496 92 29 robert robert PROPN fnp-4496 92 30 hammond1,2 hammond1,2 PROPN fnp-4496 92 31 , , PUNCT fnp-4496 92 32 qi qi PROPN fnp-4496 92 33 zhang1,2 zhang1,2 PROPN fnp-4496 92 34 1 1 NUM fnp-4496 92 35 department department NOUN fnp-4496 92 36 of of ADP fnp-4496 92 37 pathology pathology PROPN fnp-4496 92 38 & & CCONJ fnp-4496 92 39 lab lab PROPN fnp-4496 92 40 medicine medicine NOUN fnp-4496 92 41 , , PUNCT fnp-4496 92 42 university university NOUN fnp-4496 92 43 of of ADP fnp-4496 92 44 western western PROPN fnp-4496 92 45 ontario ontario PROPN fnp-4496 92 46 , , PUNCT fnp-4496 92 47 on on ADV fnp-4496 92 48 , , PUNCT fnp-4496 92 49 canada canada PROPN fnp-4496 92 50 2 2 NUM fnp-4496 92 51 department department NOUN fnp-4496 92 52 of of ADP fnp-4496 92 53 clinical clinical ADJ fnp-4496 92 54 neurological neurological ADJ fnp-4496 92 55 sciences science NOUN fnp-4496 92 56 , , PUNCT fnp-4496 92 57 university university NOUN fnp-4496 92 58 of of ADP fnp-4496 92 59 western western PROPN fnp-4496 92 60 ontario ontario PROPN fnp-4496 92 61 , , PUNCT fnp-4496 92 62 on on ADV fnp-4496 92 63 , , PUNCT fnp-4496 92 64 canada canada PROPN fnp-4496 92 65 amyloidoma amyloidoma VERB fnp-4496 92 66 is be AUX fnp-4496 92 67 a a DET fnp-4496 92 68 rare rare ADJ fnp-4496 92 69 condition condition NOUN fnp-4496 92 70 defined define VERB fnp-4496 92 71 by by ADP fnp-4496 92 72 the the DET fnp-4496 92 73 aggregation aggregation NOUN fnp-4496 92 74 of of ADP fnp-4496 92 75 amyloid amyloid NOUN fnp-4496 92 76 proteins protein NOUN fnp-4496 92 77 forming form VERB fnp-4496 92 78 a a DET fnp-4496 92 79 mass mass ADJ fnp-4496 92 80 - - PUNCT fnp-4496 92 81 like like ADJ fnp-4496 92 82 lesion lesion NOUN fnp-4496 92 83 . . PUNCT fnp-4496 93 1 while while SCONJ fnp-4496 93 2 brain brain NOUN fnp-4496 93 3 - - PUNCT fnp-4496 93 4 restricted restrict VERB fnp-4496 93 5 amyloidomas amyloidoma NOUN fnp-4496 93 6 have have AUX fnp-4496 93 7 been be AUX fnp-4496 93 8 reported report VERB fnp-4496 93 9 , , PUNCT fnp-4496 93 10 their their PRON fnp-4496 93 11 course course NOUN fnp-4496 93 12 and and CCONJ fnp-4496 93 13 pathogenesis pathogenesis NOUN fnp-4496 93 14 are be AUX fnp-4496 93 15 poorly poorly ADV fnp-4496 93 16 understood understand VERB fnp-4496 93 17 . . PUNCT fnp-4496 94 1 we we PRON fnp-4496 94 2 are be AUX fnp-4496 94 3 reporting report VERB fnp-4496 94 4 a a DET fnp-4496 94 5 case case NOUN fnp-4496 94 6 of of ADP fnp-4496 94 7 multifocal multifocal ADJ fnp-4496 94 8 brain brain NOUN fnp-4496 94 9 amyloidoma amyloidoma NOUN fnp-4496 94 10 in in ADP fnp-4496 94 11 a a DET fnp-4496 94 12 71 71 NUM fnp-4496 94 13 - - PUNCT fnp-4496 94 14 year year NOUN fnp-4496 94 15 - - PUNCT fnp-4496 94 16 old old ADJ fnp-4496 94 17 man man NOUN fnp-4496 94 18 , , PUNCT fnp-4496 94 19 which which PRON fnp-4496 94 20 is be AUX fnp-4496 94 21 significant significant ADJ fnp-4496 94 22 for for ADP fnp-4496 94 23 its its PRON fnp-4496 94 24 protracted protract VERB fnp-4496 94 25 clinical clinical ADJ fnp-4496 94 26 course course NOUN fnp-4496 94 27 and and CCONJ fnp-4496 94 28 progression progression NOUN fnp-4496 94 29 of of ADP fnp-4496 94 30 neurological neurological ADJ fnp-4496 94 31 symptoms symptom NOUN fnp-4496 94 32 . . PUNCT fnp-4496 95 1 a a DET fnp-4496 95 2 pair pair NOUN fnp-4496 95 3 of of ADP fnp-4496 95 4 stereotactic stereotactic ADJ fnp-4496 95 5 biopsies biopsy NOUN fnp-4496 95 6 revealed reveal VERB fnp-4496 95 7 the the DET fnp-4496 95 8 underlying underlie VERB fnp-4496 95 9 pathology pathology NOUN fnp-4496 95 10 . . PUNCT fnp-4496 96 1 the the DET fnp-4496 96 2 pathological pathological ADJ fnp-4496 96 3 findings finding NOUN fnp-4496 96 4 were be AUX fnp-4496 96 5 unusual unusual ADJ fnp-4496 96 6 with with ADP fnp-4496 96 7 a a DET fnp-4496 96 8 dual dual ADJ fnp-4496 96 9 picture picture NOUN fnp-4496 96 10 of of ADP fnp-4496 96 11 perivascular perivascular ADJ fnp-4496 96 12 lymphoplasmacytic lymphoplasmacytic ADJ fnp-4496 96 13 infiltration infiltration NOUN fnp-4496 96 14 in in ADP fnp-4496 96 15 the the DET fnp-4496 96 16 frontal frontal ADJ fnp-4496 96 17 area area NOUN fnp-4496 96 18 , , PUNCT fnp-4496 96 19 accompanied accompany VERB fnp-4496 96 20 by by ADP fnp-4496 96 21 amyloid amyloid NOUN fnp-4496 96 22 deposits deposit NOUN fnp-4496 96 23 in in ADP fnp-4496 96 24 occipital occipital ADJ fnp-4496 96 25 white white ADJ fnp-4496 96 26 matter matter NOUN fnp-4496 96 27 . . PUNCT fnp-4496 97 1 proteomic proteomic ADJ fnp-4496 97 2 analysis analysis NOUN fnp-4496 97 3 of of ADP fnp-4496 97 4 the the DET fnp-4496 97 5 amyloid amyloid NOUN fnp-4496 97 6 protein protein NOUN fnp-4496 97 7 by by ADP fnp-4496 97 8 mass mass ADJ fnp-4496 97 9 spectrometry spectrometry NOUN fnp-4496 97 10 was be AUX fnp-4496 97 11 also also ADV fnp-4496 97 12 curious curious ADJ fnp-4496 97 13 as as SCONJ fnp-4496 97 14 it it PRON fnp-4496 97 15 characterised characterise VERB fnp-4496 97 16 both both DET fnp-4496 97 17 lambda lambda ADJ fnp-4496 97 18 light light NOUN fnp-4496 97 19 chain chain NOUN fnp-4496 97 20 and and CCONJ fnp-4496 97 21 amyloid amyloid VERB fnp-4496 97 22 beta beta NOUN fnp-4496 97 23 - - PUNCT fnp-4496 97 24 protein protein NOUN fnp-4496 97 25 without without ADP fnp-4496 97 26 evidence evidence NOUN fnp-4496 97 27 of of ADP fnp-4496 97 28 monoclonality monoclonality NOUN fnp-4496 97 29 . . PUNCT fnp-4496 98 1 further further ADJ fnp-4496 98 2 assessments assessment NOUN fnp-4496 98 3 found find VERB fnp-4496 98 4 no no DET fnp-4496 98 5 involvement involvement NOUN fnp-4496 98 6 of of ADP fnp-4496 98 7 other other ADJ fnp-4496 98 8 organ organ NOUN fnp-4496 98 9 systems system NOUN fnp-4496 98 10 . . PUNCT fnp-4496 99 1 with with ADP fnp-4496 99 2 the the DET fnp-4496 99 3 progression progression NOUN fnp-4496 99 4 of of ADP fnp-4496 99 5 symptoms symptom NOUN fnp-4496 99 6 and and CCONJ fnp-4496 99 7 lack lack NOUN fnp-4496 99 8 of of ADP fnp-4496 99 9 definitive definitive ADJ fnp-4496 99 10 treatment treatment NOUN fnp-4496 99 11 , , PUNCT fnp-4496 99 12 the the DET fnp-4496 99 13 patient patient ADJ fnp-4496 99 14 underwent underwent NOUN fnp-4496 99 15 palliative palliative ADJ fnp-4496 99 16 whole whole ADJ fnp-4496 99 17 - - PUNCT fnp-4496 99 18 brain brain NOUN fnp-4496 99 19 irradiation irradiation NOUN fnp-4496 99 20 , , PUNCT fnp-4496 99 21 with with ADP fnp-4496 99 22 no no DET fnp-4496 99 23 improvement improvement NOUN fnp-4496 99 24 , , PUNCT fnp-4496 99 25 and and CCONJ fnp-4496 99 26 passed pass VERB fnp-4496 99 27 away away ADP fnp-4496 99 28 shortly shortly ADV fnp-4496 99 29 thereafter thereafter ADV fnp-4496 99 30 . . PUNCT fnp-4496 100 1 assessment assessment NOUN fnp-4496 100 2 of of ADP fnp-4496 100 3 post post ADJ fnp-4496 100 4 - - ADJ fnp-4496 100 5 mortem mortem ADJ fnp-4496 100 6 brain brain NOUN fnp-4496 100 7 tissue tissue NOUN fnp-4496 100 8 showed show VERB fnp-4496 100 9 massive massive ADJ fnp-4496 100 10 amyloid amyloid NOUN fnp-4496 100 11 deposition deposition NOUN fnp-4496 100 12 in in ADP fnp-4496 100 13 the the DET fnp-4496 100 14 periventricular periventricular ADJ fnp-4496 100 15 white white ADJ fnp-4496 100 16 matter matter NOUN fnp-4496 100 17 with with ADP fnp-4496 100 18 sparse sparse ADJ fnp-4496 100 19 perivascular perivascular ADJ fnp-4496 100 20 lymphocytes lymphocyte NOUN fnp-4496 100 21 and and CCONJ fnp-4496 100 22 fewer few ADJ fnp-4496 100 23 plasma plasma NOUN fnp-4496 100 24 cells cell NOUN fnp-4496 100 25 than than ADP fnp-4496 100 26 the the DET fnp-4496 100 27 biopsy biopsy NOUN fnp-4496 100 28 samples sample NOUN fnp-4496 100 29 . . PUNCT fnp-4496 101 1 special special ADJ fnp-4496 101 2 staining staining NOUN fnp-4496 101 3 , , PUNCT fnp-4496 101 4 immunohistochemistry immunohistochemistry NOUN fnp-4496 101 5 , , PUNCT fnp-4496 101 6 electron electron NOUN fnp-4496 101 7 microscopy microscopy NOUN fnp-4496 101 8 , , PUNCT fnp-4496 101 9 and and CCONJ fnp-4496 101 10 mass mass ADJ fnp-4496 101 11 spectrometry spectrometry NOUN fnp-4496 101 12 confirmed confirm VERB fnp-4496 101 13 multifocal multifocal ADJ fnp-4496 101 14 cerebral cerebral ADJ fnp-4496 101 15 amyloidoma amyloidoma NOUN fnp-4496 101 16 , , PUNCT fnp-4496 101 17 lambda lambda ADJ fnp-4496 101 18 light light NOUN fnp-4496 101 19 chain chain NOUN fnp-4496 101 20 type type NOUN fnp-4496 101 21 . . PUNCT fnp-4496 102 1 the the DET fnp-4496 102 2 collection collection NOUN fnp-4496 102 3 of of ADP fnp-4496 102 4 the the DET fnp-4496 102 5 biopsy biopsy NOUN fnp-4496 102 6 and and CCONJ fnp-4496 102 7 autopsy autopsy ADJ fnp-4496 102 8 findings finding NOUN fnp-4496 102 9 may may AUX fnp-4496 102 10 be be AUX fnp-4496 102 11 the the DET fnp-4496 102 12 result result NOUN fnp-4496 102 13 of of ADP fnp-4496 102 14 lesions lesion NOUN fnp-4496 102 15 observed observe VERB fnp-4496 102 16 at at ADP fnp-4496 102 17 different different ADJ fnp-4496 102 18 stages stage NOUN fnp-4496 102 19 of of ADP fnp-4496 102 20 progression progression NOUN fnp-4496 102 21 , , PUNCT fnp-4496 102 22 treatment treatment NOUN fnp-4496 102 23 effects effect NOUN fnp-4496 102 24 , , PUNCT fnp-4496 102 25 or or CCONJ fnp-4496 102 26 a a DET fnp-4496 102 27 not not PART fnp-4496 102 28 - - PUNCT fnp-4496 102 29 previously previously ADV fnp-4496 102 30 described describe VERB fnp-4496 102 31 pattern pattern NOUN fnp-4496 102 32 of of ADP fnp-4496 102 33 brain brain NOUN fnp-4496 102 34 amyloidoma amyloidoma VERB fnp-4496 102 35 . . PUNCT fnp-4496 103 1 studying study VERB fnp-4496 103 2 this this DET fnp-4496 103 3 case case NOUN fnp-4496 103 4 is be AUX fnp-4496 103 5 beneficial beneficial ADJ fnp-4496 103 6 to to ADP fnp-4496 103 7 gaining gain VERB fnp-4496 103 8 insight insight NOUN fnp-4496 103 9 into into ADP fnp-4496 103 10 the the DET fnp-4496 103 11 pathobiology pathobiology NOUN fnp-4496 103 12 of of ADP fnp-4496 103 13 this this DET fnp-4496 103 14 rare rare ADJ fnp-4496 103 15 condition condition NOUN fnp-4496 103 16 and and CCONJ fnp-4496 103 17 to to PART fnp-4496 103 18 inform inform VERB fnp-4496 103 19 future future ADJ fnp-4496 103 20 studies study NOUN fnp-4496 103 21 and and CCONJ fnp-4496 103 22 therapeutic therapeutic ADJ fnp-4496 103 23 interventions intervention NOUN fnp-4496 103 24 . . PUNCT fnp-4496 103 25     SPACE fnp-4496 104 1 abstract abstract ADJ fnp-4496 104 2 10 10 NUM fnp-4496 104 3 free free ADJ fnp-4496 104 4 neuropathol neuropathol NOUN fnp-4496 104 5 3:25:13 3:25:13 NUM fnp-4496 104 6 identification identification NOUN fnp-4496 104 7 and and CCONJ fnp-4496 104 8 validation validation NOUN fnp-4496 104 9 of of ADP fnp-4496 104 10 immunohistochemical immunohistochemical ADJ fnp-4496 104 11 antibodies antibody NOUN fnp-4496 104 12 against against ADP fnp-4496 104 13 transcriptomically transcriptomically ADV fnp-4496 104 14 distinct distinct ADJ fnp-4496 104 15 human human ADJ fnp-4496 104 16 hippocampal hippocampal NOUN fnp-4496 104 17 astrocyte astrocyte NOUN fnp-4496 104 18 subtypes subtype NOUN fnp-4496 104 19 brenden brenden PROPN fnp-4496 104 20 joseph1,2 joseph1,2 PROPN fnp-4496 104 21 , , PUNCT fnp-4496 104 22 kaitlin kaitlin PROPN fnp-4496 104 23 sullivan3 sullivan3 PROPN fnp-4496 104 24 , , PUNCT fnp-4496 104 25 mark mark PROPN fnp-4496 104 26 s. s. PROPN fnp-4496 104 27 cembrowski3 cembrowski3 PROPN fnp-4496 104 28 , , PUNCT fnp-4496 104 29 veronica veronica PROPN fnp-4496 104 30 hirsch hirsch PROPN fnp-4496 104 31 - - PUNCT fnp-4496 104 32 reinshagen1,2 reinshagen1,2 PROPN fnp-4496 104 33 1 1 NUM fnp-4496 104 34 department department NOUN fnp-4496 104 35 of of ADP fnp-4496 104 36 pathology pathology PROPN fnp-4496 104 37 & & CCONJ fnp-4496 104 38 laboratory laboratory PROPN fnp-4496 104 39 medicine medicine NOUN fnp-4496 104 40 , , PUNCT fnp-4496 104 41 university university NOUN fnp-4496 104 42 of of ADP fnp-4496 104 43 british british PROPN fnp-4496 104 44 columbia columbia PROPN fnp-4496 104 45 , , PUNCT fnp-4496 104 46 vancouver vancouver PROPN fnp-4496 104 47 , , PUNCT fnp-4496 104 48 bc bc PROPN fnp-4496 104 49 , , PUNCT fnp-4496 104 50 canada canada PROPN fnp-4496 104 51 2 2 NUM fnp-4496 104 52 division division NOUN fnp-4496 104 53 of of ADP fnp-4496 104 54 neuropathology neuropathology NOUN fnp-4496 104 55 , , PUNCT fnp-4496 104 56 vancouver vancouver PROPN fnp-4496 104 57 general general PROPN fnp-4496 104 58 hospital hospital PROPN fnp-4496 104 59 , , PUNCT fnp-4496 104 60 vancouver vancouver PROPN fnp-4496 104 61 , , PUNCT fnp-4496 104 62 bc bc PROPN fnp-4496 104 63 , , PUNCT fnp-4496 104 64 canada canada PROPN fnp-4496 104 65 3 3 NUM fnp-4496 104 66 department department NOUN fnp-4496 104 67 of of ADP fnp-4496 104 68 cellular cellular ADJ fnp-4496 104 69 and and CCONJ fnp-4496 104 70 physiological physiological ADJ fnp-4496 104 71 sciences science NOUN fnp-4496 104 72 , , PUNCT fnp-4496 104 73 djavad djavad PROPN fnp-4496 104 74 mowafaghian mowafaghian PROPN fnp-4496 104 75 centre centre PROPN fnp-4496 104 76 for for ADP fnp-4496 104 77 brain brain NOUN fnp-4496 104 78 health health NOUN fnp-4496 104 79 , , PUNCT fnp-4496 104 80 university university NOUN fnp-4496 104 81 of of ADP fnp-4496 104 82 british british PROPN fnp-4496 104 83 columbia columbia PROPN fnp-4496 104 84 , , PUNCT fnp-4496 104 85 vancouver vancouver PROPN fnp-4496 104 86 , , PUNCT fnp-4496 104 87 bc bc PROPN fnp-4496 104 88 , , PUNCT fnp-4496 104 89 canada canada PROPN fnp-4496 104 90 our our PRON fnp-4496 104 91 understanding understanding NOUN fnp-4496 104 92 of of ADP fnp-4496 104 93 astrocyte astrocyte NOUN fnp-4496 104 94 function function NOUN fnp-4496 104 95 has have AUX fnp-4496 104 96 steadily steadily ADV fnp-4496 104 97 evolved evolve VERB fnp-4496 104 98 from from ADP fnp-4496 104 99 an an DET fnp-4496 104 100 early early ADJ fnp-4496 104 101 conceptualization conceptualization NOUN fnp-4496 104 102 as as ADP fnp-4496 104 103 simplistic simplistic ADJ fnp-4496 104 104 support support NOUN fnp-4496 104 105 cells cell NOUN fnp-4496 104 106 to to ADP fnp-4496 104 107 a a DET fnp-4496 104 108 current current ADJ fnp-4496 104 109 appreciation appreciation NOUN fnp-4496 104 110 for for ADP fnp-4496 104 111 their their PRON fnp-4496 104 112 diverse diverse ADJ fnp-4496 104 113 and and CCONJ fnp-4496 104 114 critical critical ADJ fnp-4496 104 115 physiological physiological ADJ fnp-4496 104 116 roles role NOUN fnp-4496 104 117 . . PUNCT fnp-4496 105 1 there there PRON fnp-4496 105 2 is be VERB fnp-4496 105 3 emerging emerge VERB fnp-4496 105 4 evidence evidence NOUN fnp-4496 105 5 for for ADP fnp-4496 105 6 the the DET fnp-4496 105 7 existence existence NOUN fnp-4496 105 8 of of ADP fnp-4496 105 9 distinct distinct ADJ fnp-4496 105 10 astrocyte astrocyte NOUN fnp-4496 105 11 subtypes subtype NOUN fnp-4496 105 12 with with ADP fnp-4496 105 13 differential differential ADJ fnp-4496 105 14 genomic genomic NOUN fnp-4496 105 15 expression expression NOUN fnp-4496 105 16 , , PUNCT fnp-4496 105 17 spatial spatial ADJ fnp-4496 105 18 localization localization NOUN fnp-4496 105 19 , , PUNCT fnp-4496 105 20 morphology morphology NOUN fnp-4496 105 21 , , PUNCT fnp-4496 105 22 and and CCONJ fnp-4496 105 23 physiological physiological ADJ fnp-4496 105 24 function function NOUN fnp-4496 105 25 . . PUNCT fnp-4496 106 1 however however ADV fnp-4496 106 2 , , PUNCT fnp-4496 106 3 little little ADJ fnp-4496 106 4 is be AUX fnp-4496 106 5 known know VERB fnp-4496 106 6 about about ADP fnp-4496 106 7 their their PRON fnp-4496 106 8 specialized specialized ADJ fnp-4496 106 9 functions function NOUN fnp-4496 106 10 or or CCONJ fnp-4496 106 11 the the DET fnp-4496 106 12 role role NOUN fnp-4496 106 13 of of ADP fnp-4496 106 14 specific specific ADJ fnp-4496 106 15 subtypes subtype NOUN fnp-4496 106 16 in in ADP fnp-4496 106 17 human human ADJ fnp-4496 106 18 disease disease NOUN fnp-4496 106 19 . . PUNCT fnp-4496 107 1 a a DET fnp-4496 107 2 lack lack NOUN fnp-4496 107 3 of of ADP fnp-4496 107 4 established establish VERB fnp-4496 107 5 subtype subtype NOUN fnp-4496 107 6 - - PUNCT fnp-4496 107 7 specific specific ADJ fnp-4496 107 8 immunohistochemical immunohistochemical ADJ fnp-4496 107 9 markers marker NOUN fnp-4496 107 10 represents represent VERB fnp-4496 107 11 a a DET fnp-4496 107 12 significant significant ADJ fnp-4496 107 13 barrier barrier NOUN fnp-4496 107 14 to to ADP fnp-4496 107 15 further further ADJ fnp-4496 107 16 investigation investigation NOUN fnp-4496 107 17 . . PUNCT fnp-4496 108 1 to to PART fnp-4496 108 2 address address VERB fnp-4496 108 3 this this DET fnp-4496 108 4 limitation limitation NOUN fnp-4496 108 5 , , PUNCT fnp-4496 108 6 we we PRON fnp-4496 108 7 aim aim VERB fnp-4496 108 8 to to PART fnp-4496 108 9 identify identify VERB fnp-4496 108 10 transcriptomically transcriptomically ADV fnp-4496 108 11 distinct distinct ADJ fnp-4496 108 12 human human ADJ fnp-4496 108 13 astrocyte astrocyte NOUN fnp-4496 108 14 subtypes subtype NOUN fnp-4496 108 15 and and CCONJ fnp-4496 108 16 validate validate VERB fnp-4496 108 17 immunohistochemical immunohistochemical ADJ fnp-4496 108 18 markers marker NOUN fnp-4496 108 19 for for ADP fnp-4496 108 20 these these PRON fnp-4496 108 21 . . PUNCT fnp-4496 109 1 to to PART fnp-4496 109 2 identify identify VERB fnp-4496 109 3 distinct distinct ADJ fnp-4496 109 4 transcriptomic transcriptomic ADJ fnp-4496 109 5 subtypes subtype NOUN fnp-4496 109 6 of of ADP fnp-4496 109 7 human human ADJ fnp-4496 109 8 astrocytes astrocyte NOUN fnp-4496 109 9 , , PUNCT fnp-4496 109 10 we we PRON fnp-4496 109 11 used use VERB fnp-4496 109 12 single single ADJ fnp-4496 109 13 cell cell NOUN fnp-4496 109 14 nuclear nuclear ADJ fnp-4496 109 15 rna rna NOUN fnp-4496 109 16 sequencing sequencing NOUN fnp-4496 109 17 of of ADP fnp-4496 109 18 11,204 11,204 NUM fnp-4496 109 19 astrocytes astrocyte NOUN fnp-4496 109 20 in in ADP fnp-4496 109 21 human human ADJ fnp-4496 109 22 hippocampal hippocampal ADJ fnp-4496 109 23 surgical surgical ADJ fnp-4496 109 24 samples sample NOUN fnp-4496 109 25 from from ADP fnp-4496 109 26 5 5 NUM fnp-4496 109 27 patients patient NOUN fnp-4496 109 28 with with ADP fnp-4496 109 29 intractable intractable ADJ fnp-4496 109 30 mesiotemporal mesiotemporal ADJ fnp-4496 109 31 epilepsy epilepsy NOUN fnp-4496 109 32 . . PUNCT fnp-4496 110 1 canonical canonical ADJ fnp-4496 110 2 correlation correlation NOUN fnp-4496 110 3 and and CCONJ fnp-4496 110 4 seurat seurat PROPN fnp-4496 110 5 cluster cluster NOUN fnp-4496 110 6 analysis analysis NOUN fnp-4496 110 7 identified identify VERB fnp-4496 110 8 6 6 NUM fnp-4496 110 9 distinct distinct ADJ fnp-4496 110 10 clusters cluster NOUN fnp-4496 110 11 of of ADP fnp-4496 110 12 astrocytes astrocyte NOUN fnp-4496 110 13 with with ADP fnp-4496 110 14 unique unique ADJ fnp-4496 110 15 transcriptomes transcriptome NOUN fnp-4496 110 16 and and CCONJ fnp-4496 110 17 revealed reveal VERB fnp-4496 110 18 several several ADJ fnp-4496 110 19 candidate candidate NOUN fnp-4496 110 20 marker marker NOUN fnp-4496 110 21 genes gene NOUN fnp-4496 110 22 unique unique ADJ fnp-4496 110 23 to to ADP fnp-4496 110 24 each each DET fnp-4496 110 25 cluster cluster NOUN fnp-4496 110 26 . . PUNCT fnp-4496 111 1 we we PRON fnp-4496 111 2 are be AUX fnp-4496 111 3 currently currently ADV fnp-4496 111 4 validating validate VERB fnp-4496 111 5 c8orf34 c8orf34 NOUN fnp-4496 111 6 and and CCONJ fnp-4496 111 7 nrg4 nrg4 VERB fnp-4496 111 8 as as ADP fnp-4496 111 9 subtype subtype NOUN fnp-4496 111 10 specific specific ADJ fnp-4496 111 11 markers marker NOUN fnp-4496 111 12 for for ADP fnp-4496 111 13 cluster cluster NOUN fnp-4496 111 14 5 5 NUM fnp-4496 111 15 , , PUNCT fnp-4496 111 16 which which PRON fnp-4496 111 17 was be AUX fnp-4496 111 18 the the DET fnp-4496 111 19 most most ADV fnp-4496 111 20 transcriptomically transcriptomically ADV fnp-4496 111 21 unique unique ADJ fnp-4496 111 22 cluster cluster NOUN fnp-4496 111 23 . . PUNCT fnp-4496 112 1 the the DET fnp-4496 112 2 study study NOUN fnp-4496 112 3 ’s ’s PART fnp-4496 112 4 current current ADJ fnp-4496 112 5 and and CCONJ fnp-4496 112 6 future future ADJ fnp-4496 112 7 directions direction NOUN fnp-4496 112 8 include include VERB fnp-4496 112 9 the the DET fnp-4496 112 10 selection selection NOUN fnp-4496 112 11 of of ADP fnp-4496 112 12 commercially commercially ADV fnp-4496 112 13 available available ADJ fnp-4496 112 14 antibodies antibody NOUN fnp-4496 112 15 against against ADP fnp-4496 112 16 candidate candidate NOUN fnp-4496 112 17 marker marker NOUN fnp-4496 112 18 gene gene NOUN fnp-4496 112 19 products product NOUN fnp-4496 112 20 and and CCONJ fnp-4496 112 21 validation validation NOUN fnp-4496 112 22 of of ADP fnp-4496 112 23 these these DET fnp-4496 112 24 subtype subtype NOUN fnp-4496 112 25 - - PUNCT fnp-4496 112 26 specific specific ADJ fnp-4496 112 27 antibodies antibody NOUN fnp-4496 112 28 using use VERB fnp-4496 112 29 doubleand doubleand NOUN fnp-4496 112 30 triple triple ADJ fnp-4496 112 31 - - PUNCT fnp-4496 112 32 label label NOUN fnp-4496 112 33 immunofluorescence immunofluorescence NOUN fnp-4496 112 34 microscopy microscopy NOUN fnp-4496 112 35 with with ADP fnp-4496 112 36 other other ADJ fnp-4496 112 37 established establish VERB fnp-4496 112 38 markers marker NOUN fnp-4496 112 39 for for ADP fnp-4496 112 40 various various ADJ fnp-4496 112 41 cns cns NOUN fnp-4496 112 42 cell cell NOUN fnp-4496 112 43 types type NOUN fnp-4496 112 44 . . PUNCT fnp-4496 113 1 establishing establish VERB fnp-4496 113 2 validated validated ADJ fnp-4496 113 3 antibodies antibody NOUN fnp-4496 113 4 will will AUX fnp-4496 113 5 lead lead VERB fnp-4496 113 6 to to ADP fnp-4496 113 7 the the DET fnp-4496 113 8 discovery discovery NOUN fnp-4496 113 9 of of ADP fnp-4496 113 10 subtype subtype NOUN fnp-4496 113 11 - - PUNCT fnp-4496 113 12 specific specific ADJ fnp-4496 113 13 involvement involvement NOUN fnp-4496 113 14 of of ADP fnp-4496 113 15 astrocytes astrocyte NOUN fnp-4496 113 16 in in ADP fnp-4496 113 17 human human ADJ fnp-4496 113 18 neurological neurological ADJ fnp-4496 113 19 and and CCONJ fnp-4496 113 20 psychiatric psychiatric ADJ fnp-4496 113 21 conditions condition NOUN fnp-4496 113 22 and and CCONJ fnp-4496 113 23 advancements advancement NOUN fnp-4496 113 24 in in ADP fnp-4496 113 25 our our PRON fnp-4496 113 26 understanding understanding NOUN fnp-4496 113 27 of of ADP fnp-4496 113 28 human human ADJ fnp-4496 113 29 astrocyte astrocyte NOUN fnp-4496 113 30 physiology physiology NOUN fnp-4496 113 31 . . PUNCT fnp-4496 113 32     SPACE fnp-4496 114 1 abstract abstract ADJ fnp-4496 114 2 11 11 NUM fnp-4496 114 3 free free ADJ fnp-4496 114 4 neuropathol neuropathol NOUN fnp-4496 114 5 3:25:14 3:25:14 NUM fnp-4496 114 6 cadherin-23 cadherin-23 PROPN fnp-4496 114 7 is be AUX fnp-4496 114 8 essential essential ADJ fnp-4496 114 9 for for ADP fnp-4496 114 10 the the DET fnp-4496 114 11 normal normal ADJ fnp-4496 114 12 organisation organisation NOUN fnp-4496 114 13 of of ADP fnp-4496 114 14 cerebellar cerebellar ADJ fnp-4496 114 15 mossy mossy PROPN fnp-4496 114 16 fibre fibre NOUN fnp-4496 114 17 synapses synapse VERB fnp-4496 114 18 madison madison PROPN fnp-4496 114 19 t. t. PROPN fnp-4496 114 20 gray1,2,3 gray1,2,3 PROPN fnp-4496 114 21 , , PUNCT fnp-4496 114 22 julie julie PROPN fnp-4496 114 23 l. l. PROPN fnp-4496 114 24 lefebvre2,3 lefebvre2,3 PROPN fnp-4496 114 25 1 1 NUM fnp-4496 114 26 department department NOUN fnp-4496 114 27 of of ADP fnp-4496 114 28 pathology pathology NOUN fnp-4496 114 29 and and CCONJ fnp-4496 114 30 laboratory laboratory NOUN fnp-4496 114 31 medicine medicine NOUN fnp-4496 114 32 , , PUNCT fnp-4496 114 33 western western ADJ fnp-4496 114 34 university university NOUN fnp-4496 114 35 , , PUNCT fnp-4496 114 36 london london PROPN fnp-4496 114 37 , , PUNCT fnp-4496 114 38 on on ADP fnp-4496 114 39 , , PUNCT fnp-4496 114 40 canada canada PROPN fnp-4496 114 41 2 2 NUM fnp-4496 114 42 neuroscience neuroscience NOUN fnp-4496 114 43 and and CCONJ fnp-4496 114 44 mental mental ADJ fnp-4496 114 45 health health NOUN fnp-4496 114 46 , , PUNCT fnp-4496 114 47 hospital hospital NOUN fnp-4496 114 48 for for ADP fnp-4496 114 49 sick sick ADJ fnp-4496 114 50 children child NOUN fnp-4496 114 51 , , PUNCT fnp-4496 114 52 toronto toronto PROPN fnp-4496 114 53 , , PUNCT fnp-4496 114 54 on on ADP fnp-4496 114 55 , , PUNCT fnp-4496 114 56 canada canada PROPN fnp-4496 114 57 3 3 NUM fnp-4496 114 58 department department NOUN fnp-4496 114 59 of of ADP fnp-4496 114 60 molecular molecular ADJ fnp-4496 114 61 genetics genetic NOUN fnp-4496 114 62 , , PUNCT fnp-4496 114 63 faculty faculty NOUN fnp-4496 114 64 of of ADP fnp-4496 114 65 medicine medicine NOUN fnp-4496 114 66 , , PUNCT fnp-4496 114 67 university university PROPN fnp-4496 114 68 of of ADP fnp-4496 114 69 toronto toronto PROPN fnp-4496 114 70 , , PUNCT fnp-4496 114 71 toronto toronto PROPN fnp-4496 114 72 , , PUNCT fnp-4496 114 73 on on ADP fnp-4496 114 74 , , PUNCT fnp-4496 114 75 canada canada PROPN fnp-4496 114 76 to to PART fnp-4496 114 77 understand understand VERB fnp-4496 114 78 the the DET fnp-4496 114 79 physiological physiological ADJ fnp-4496 114 80 basis basis NOUN fnp-4496 114 81 of of ADP fnp-4496 114 82 neurological neurological ADJ fnp-4496 114 83 disease disease NOUN fnp-4496 114 84 , , PUNCT fnp-4496 114 85 one one PRON fnp-4496 114 86 must must AUX fnp-4496 114 87 first first ADV fnp-4496 114 88 identify identify VERB fnp-4496 114 89 which which PRON fnp-4496 114 90 neurons neuron NOUN fnp-4496 114 91 are be AUX fnp-4496 114 92 connected connect VERB fnp-4496 114 93 and and CCONJ fnp-4496 114 94 how how SCONJ fnp-4496 114 95 they they PRON fnp-4496 114 96 form form VERB fnp-4496 114 97 those those DET fnp-4496 114 98 connections connection NOUN fnp-4496 114 99 . . PUNCT fnp-4496 115 1 here here ADV fnp-4496 115 2 , , PUNCT fnp-4496 115 3 we we PRON fnp-4496 115 4 identify identify VERB fnp-4496 115 5 a a DET fnp-4496 115 6 novel novel ADJ fnp-4496 115 7 cell cell NOUN fnp-4496 115 8 adhesion adhesion NOUN fnp-4496 115 9 molecule molecule NOUN fnp-4496 115 10 signature signature NOUN fnp-4496 115 11 in in ADP fnp-4496 115 12 golgi golgi NOUN fnp-4496 115 13 cells cell NOUN fnp-4496 115 14 , , PUNCT fnp-4496 115 15 an an DET fnp-4496 115 16 inhibitory inhibitory ADJ fnp-4496 115 17 interneuron interneuron NOUN fnp-4496 115 18 in in ADP fnp-4496 115 19 the the DET fnp-4496 115 20 granular granular ADJ fnp-4496 115 21 layer layer NOUN fnp-4496 115 22 of of ADP fnp-4496 115 23 the the DET fnp-4496 115 24 cerebellar cerebellar ADJ fnp-4496 115 25 cortex cortex NOUN fnp-4496 115 26 . . PUNCT fnp-4496 116 1 golgi golgi PROPN fnp-4496 116 2 cells cell NOUN fnp-4496 116 3 receive receive VERB fnp-4496 116 4 excitatory excitatory ADJ fnp-4496 116 5 input input NOUN fnp-4496 116 6 from from ADP fnp-4496 116 7 both both CCONJ fnp-4496 116 8 precerebellar precerebellar NOUN fnp-4496 116 9 mossy mossy ADJ fnp-4496 116 10 fibres fibre NOUN fnp-4496 116 11 and and CCONJ fnp-4496 116 12 cerebellar cerebellar ADJ fnp-4496 116 13 granule granule NOUN fnp-4496 116 14 cells cell NOUN fnp-4496 116 15 , , PUNCT fnp-4496 116 16 while while SCONJ fnp-4496 116 17 providing provide VERB fnp-4496 116 18 inhibition inhibition NOUN fnp-4496 116 19 to to ADP fnp-4496 116 20 those those DET fnp-4496 116 21 same same ADJ fnp-4496 116 22 granule granule NOUN fnp-4496 116 23 cells cell NOUN fnp-4496 116 24 in in ADP fnp-4496 116 25 a a DET fnp-4496 116 26 feedback feedback NOUN fnp-4496 116 27 loop loop NOUN fnp-4496 116 28 . . PUNCT fnp-4496 117 1 we we PRON fnp-4496 117 2 show show VERB fnp-4496 117 3 that that SCONJ fnp-4496 117 4 both both DET fnp-4496 117 5 golgi golgi NOUN fnp-4496 117 6 cells cell NOUN fnp-4496 117 7 and and CCONJ fnp-4496 117 8 their their PRON fnp-4496 117 9 mossy mossy NOUN fnp-4496 117 10 fibre fibre NOUN fnp-4496 117 11 partners partner NOUN fnp-4496 117 12 express express VERB fnp-4496 117 13 cadherin cadherin NOUN fnp-4496 117 14 23 23 NUM fnp-4496 117 15 ( ( PUNCT fnp-4496 117 16 cdh23 cdh23 NOUN fnp-4496 117 17 ) ) PUNCT fnp-4496 117 18 – – PUNCT fnp-4496 117 19 a a DET fnp-4496 117 20 pattern pattern NOUN fnp-4496 117 21 conserved conserve VERB fnp-4496 117 22 in in ADP fnp-4496 117 23 evolution evolution NOUN fnp-4496 117 24 . . PUNCT fnp-4496 118 1 using use VERB fnp-4496 118 2 explant explant ADJ fnp-4496 118 3 cultures culture NOUN fnp-4496 118 4 in in ADP fnp-4496 118 5 vitro vitro X fnp-4496 118 6 and and CCONJ fnp-4496 118 7 ectopic ectopic VERB fnp-4496 118 8 viral viral ADJ fnp-4496 118 9 expression expression NOUN fnp-4496 118 10 in in ADP fnp-4496 118 11 vivo vivo NOUN fnp-4496 118 12 , , PUNCT fnp-4496 118 13 we we PRON fnp-4496 118 14 demonstrate demonstrate VERB fnp-4496 118 15 that that SCONJ fnp-4496 118 16 cdh23 cdh23 PROPN fnp-4496 118 17 is be AUX fnp-4496 118 18 sufficient sufficient ADJ fnp-4496 118 19 to to PART fnp-4496 118 20 induce induce VERB fnp-4496 118 21 the the DET fnp-4496 118 22 formation formation NOUN fnp-4496 118 23 of of ADP fnp-4496 118 24 synapses synapsis NOUN fnp-4496 118 25 by by ADP fnp-4496 118 26 mossy mossy ADJ fnp-4496 118 27 fibres fibre NOUN fnp-4496 118 28 . . PUNCT fnp-4496 119 1 the the DET fnp-4496 119 2 known know VERB fnp-4496 119 3 in in ADP fnp-4496 119 4 vivo vivo ADJ fnp-4496 119 5 roles role NOUN fnp-4496 119 6 of of ADP fnp-4496 119 7 cdh23 cdh23 NOUN fnp-4496 119 8 depend depend VERB fnp-4496 119 9 on on ADP fnp-4496 119 10 binding bind VERB fnp-4496 119 11 protocadherin protocadherin NOUN fnp-4496 119 12 15 15 NUM fnp-4496 119 13 ( ( PUNCT fnp-4496 119 14 pcdh15 pcdh15 NOUN fnp-4496 119 15 ) ) PUNCT fnp-4496 119 16 in in ADP fnp-4496 119 17 trans tran NOUN fnp-4496 119 18 . . PUNCT fnp-4496 120 1 however however ADV fnp-4496 120 2 , , PUNCT fnp-4496 120 3 here here ADV fnp-4496 120 4 we we PRON fnp-4496 120 5 show show VERB fnp-4496 120 6 that that DET fnp-4496 120 7 pcdh15 pcdh15 NOUN fnp-4496 120 8 is be AUX fnp-4496 120 9 not not PART fnp-4496 120 10 expressed express VERB fnp-4496 120 11 in in ADP fnp-4496 120 12 mossy mossy ADJ fnp-4496 120 13 fibre fibre NOUN fnp-4496 120 14 neurons neuron NOUN fnp-4496 120 15 , , PUNCT fnp-4496 120 16 golgi golgi NOUN fnp-4496 120 17 cells cell NOUN fnp-4496 120 18 , , PUNCT fnp-4496 120 19 or or CCONJ fnp-4496 120 20 their their PRON fnp-4496 120 21 cerebellar cerebellar ADJ fnp-4496 120 22 targets target NOUN fnp-4496 120 23 . . PUNCT fnp-4496 121 1 a a DET fnp-4496 121 2 cdh23 cdh23 NOUN fnp-4496 121 3 mutant mutant NOUN fnp-4496 121 4 incapable incapable ADJ fnp-4496 121 5 of of ADP fnp-4496 121 6 binding bind VERB fnp-4496 121 7 pcdh15 pcdh15 NOUN fnp-4496 121 8 nonetheless nonetheless ADV fnp-4496 121 9 induces induce VERB fnp-4496 121 10 mossy mossy ADJ fnp-4496 121 11 fibre fibre NOUN fnp-4496 121 12 synapses synapsis NOUN fnp-4496 121 13 in in ADP fnp-4496 121 14 vitro vitro X fnp-4496 121 15 and and CCONJ fnp-4496 121 16 in in ADP fnp-4496 121 17 vivo vivo NOUN fnp-4496 121 18 , , PUNCT fnp-4496 121 19 confirming confirm VERB fnp-4496 121 20 that that SCONJ fnp-4496 121 21 the the DET fnp-4496 121 22 synaptic synaptic ADJ fnp-4496 121 23 organiser organiser NOUN fnp-4496 121 24 function function NOUN fnp-4496 121 25 of of ADP fnp-4496 121 26 cdh23 cdh23 PROPN fnp-4496 121 27 is be AUX fnp-4496 121 28 independent independent ADJ fnp-4496 121 29 of of ADP fnp-4496 121 30 pcdh15 pcdh15 ADJ fnp-4496 121 31 binding bind VERB fnp-4496 121 32 . . PUNCT fnp-4496 122 1 finally finally ADV fnp-4496 122 2 , , PUNCT fnp-4496 122 3 analysis analysis NOUN fnp-4496 122 4 of of ADP fnp-4496 122 5 a a DET fnp-4496 122 6 cdh23 cdh23 NOUN fnp-4496 122 7 - - PUNCT fnp-4496 122 8 null null NOUN fnp-4496 122 9 mouse mouse NOUN fnp-4496 122 10 reveals reveal VERB fnp-4496 122 11 that that SCONJ fnp-4496 122 12 cdh23 cdh23 PROPN fnp-4496 122 13 is be AUX fnp-4496 122 14 not not PART fnp-4496 122 15 necessary necessary ADJ fnp-4496 122 16 for for ADP fnp-4496 122 17 anatomical anatomical ADJ fnp-4496 122 18 synapse synapse NOUN fnp-4496 122 19 formation formation NOUN fnp-4496 122 20 but but CCONJ fnp-4496 122 21 mossy mossy ADJ fnp-4496 122 22 fibres fibre NOUN fnp-4496 122 23 . . PUNCT fnp-4496 123 1 however however ADV fnp-4496 123 2 , , PUNCT fnp-4496 123 3 loss loss NOUN fnp-4496 123 4 of of ADP fnp-4496 123 5 cdh23 cdh23 NOUN fnp-4496 123 6 results result VERB fnp-4496 123 7 in in ADP fnp-4496 123 8 enlarged enlarge VERB fnp-4496 123 9 , , PUNCT fnp-4496 123 10 sparse sparse ADJ fnp-4496 123 11 mossy mossy NOUN fnp-4496 123 12 fibre fibre NOUN fnp-4496 123 13 terminals terminal NOUN fnp-4496 123 14 suggesting suggest VERB fnp-4496 123 15 a a DET fnp-4496 123 16 role role NOUN fnp-4496 123 17 for for ADP fnp-4496 123 18 cdh23 cdh23 PROPN fnp-4496 123 19 in in ADP fnp-4496 123 20 mossy mossy NOUN fnp-4496 123 21 fibre fibre NOUN fnp-4496 123 22 bouton bouton NOUN fnp-4496 123 23 development development NOUN fnp-4496 123 24 . . PUNCT fnp-4496 123 25     SPACE fnp-4496 124 1 abstract abstract ADJ fnp-4496 124 2 12 12 NUM fnp-4496 124 3 free free ADJ fnp-4496 124 4 neuropathol neuropathol NOUN fnp-4496 124 5 3:25:15 3:25:15 NUM fnp-4496 124 6 the the DET fnp-4496 124 7 extracellular extracellular ADJ fnp-4496 124 8 matrix matrix NOUN fnp-4496 124 9 transcriptome transcriptome NOUN fnp-4496 124 10 following follow VERB fnp-4496 124 11 demyelination demyelination NOUN fnp-4496 124 12 erin erin PROPN fnp-4496 124 13 l. l. PROPN fnp-4496 124 14 stephenson1 stephenson1 PROPN fnp-4496 124 15 , , PUNCT fnp-4496 124 16 samira samira PROPN fnp-4496 124 17 ghorbanigazar2 ghorbanigazar2 PROPN fnp-4496 124 18 , , PUNCT fnp-4496 124 19 charlotte charlotte PROPN fnp-4496 124 20 d’mello2 d’mello2 PROPN fnp-4496 124 21 , , PUNCT fnp-4496 124 22 rajiv rajiv PROPN fnp-4496 124 23 william william PROPN fnp-4496 124 24 jain2 jain2 PROPN fnp-4496 124 25 , , PUNCT fnp-4496 124 26 v. v. ADP fnp-4496 124 27 wee wee ADJ fnp-4496 124 28 yong2 yong2 PROPN fnp-4496 124 29 1 1 NUM fnp-4496 124 30 department department NOUN fnp-4496 124 31 of of ADP fnp-4496 124 32 pathology pathology NOUN fnp-4496 124 33 and and CCONJ fnp-4496 124 34 laboratory laboratory NOUN fnp-4496 124 35 medicine medicine NOUN fnp-4496 124 36 , , PUNCT fnp-4496 124 37 university university NOUN fnp-4496 124 38 of of ADP fnp-4496 124 39 calgary calgary PROPN fnp-4496 124 40 , , PUNCT fnp-4496 124 41 calgary calgary PROPN fnp-4496 124 42 , , PUNCT fnp-4496 124 43 ab ab PROPN fnp-4496 124 44 , , PUNCT fnp-4496 124 45 canada canada PROPN fnp-4496 124 46 2 2 NUM fnp-4496 124 47 hotchkiss hotchkiss PROPN fnp-4496 124 48 brain brain PROPN fnp-4496 124 49 institute institute PROPN fnp-4496 124 50 , , PUNCT fnp-4496 124 51 university university PROPN fnp-4496 124 52 of of ADP fnp-4496 124 53 calgary calgary PROPN fnp-4496 124 54 , , PUNCT fnp-4496 124 55 calgary calgary PROPN fnp-4496 124 56 , , PUNCT fnp-4496 124 57 ab ab PROPN fnp-4496 124 58 , , PUNCT fnp-4496 124 59 canada canada PROPN fnp-4496 124 60 the the DET fnp-4496 124 61 extracellular extracellular ADJ fnp-4496 124 62 matrix matrix NOUN fnp-4496 124 63 ( ( PUNCT fnp-4496 124 64 ecm ecm NOUN fnp-4496 124 65 ) ) PUNCT fnp-4496 124 66 of of ADP fnp-4496 124 67 the the DET fnp-4496 124 68 central central ADJ fnp-4496 124 69 nervous nervous ADJ fnp-4496 124 70 system system NOUN fnp-4496 124 71 ( ( PUNCT fnp-4496 124 72 cns cns NOUN fnp-4496 124 73 ) ) PUNCT fnp-4496 124 74 is be AUX fnp-4496 124 75 an an DET fnp-4496 124 76 interconnected interconnected ADJ fnp-4496 124 77 network network NOUN fnp-4496 124 78 of of ADP fnp-4496 124 79 proteins protein NOUN fnp-4496 124 80 and and CCONJ fnp-4496 124 81 sugars sugar NOUN fnp-4496 124 82 . . PUNCT fnp-4496 125 1 the the DET fnp-4496 125 2 ecm ecm PROPN fnp-4496 125 3 has have VERB fnp-4496 125 4 critical critical ADJ fnp-4496 125 5 roles role NOUN fnp-4496 125 6 not not PART fnp-4496 125 7 only only ADV fnp-4496 125 8 in in ADP fnp-4496 125 9 homeostasis homeostasis NOUN fnp-4496 125 10 , , PUNCT fnp-4496 125 11 but but CCONJ fnp-4496 125 12 ecm ecm NOUN fnp-4496 125 13 remodeling remodeling NOUN fnp-4496 125 14 in in ADP fnp-4496 125 15 neurological neurological ADJ fnp-4496 125 16 diseases disease NOUN fnp-4496 125 17 impacts impact NOUN fnp-4496 125 18 both both DET fnp-4496 125 19 injury injury NOUN fnp-4496 125 20 and and CCONJ fnp-4496 125 21 repair repair NOUN fnp-4496 125 22 . . PUNCT fnp-4496 126 1 multiple multiple ADJ fnp-4496 126 2 sclerosis sclerosis NOUN fnp-4496 126 3 ( ( PUNCT fnp-4496 126 4 ms ms NOUN fnp-4496 126 5 ) ) PUNCT fnp-4496 126 6 is be AUX fnp-4496 126 7 a a DET fnp-4496 126 8 chronic chronic ADJ fnp-4496 126 9 inflammatory inflammatory ADJ fnp-4496 126 10 and and CCONJ fnp-4496 126 11 degenerative degenerative ADJ fnp-4496 126 12 disease disease NOUN fnp-4496 126 13 of of ADP fnp-4496 126 14 the the DET fnp-4496 126 15 cns cns NOUN fnp-4496 126 16 . . PUNCT fnp-4496 127 1 here here ADV fnp-4496 127 2 , , PUNCT fnp-4496 127 3 we we PRON fnp-4496 127 4 evaluated evaluate VERB fnp-4496 127 5 ecm ecm NOUN fnp-4496 127 6 changes change NOUN fnp-4496 127 7 in in ADP fnp-4496 127 8 ms ms ADJ fnp-4496 127 9 lesions lesion NOUN fnp-4496 127 10 compared compare VERB fnp-4496 127 11 to to ADP fnp-4496 127 12 controls control NOUN fnp-4496 127 13 using use VERB fnp-4496 127 14 databases database NOUN fnp-4496 127 15 generated generate VERB fnp-4496 127 16 in in ADP fnp-4496 127 17 - - PUNCT fnp-4496 127 18 house house NOUN fnp-4496 127 19 through through ADP fnp-4496 127 20 spatial spatial ADJ fnp-4496 127 21 rna rna NOUN fnp-4496 127 22 - - PUNCT fnp-4496 127 23 sequencing sequence VERB fnp-4496 127 24 , , PUNCT fnp-4496 127 25 and and CCONJ fnp-4496 127 26 through through ADP fnp-4496 127 27 a a DET fnp-4496 127 28 public public ADJ fnp-4496 127 29 resource resource NOUN fnp-4496 127 30 of of ADP fnp-4496 127 31 single single ADJ fnp-4496 127 32 - - PUNCT fnp-4496 127 33 nucleus nucleus NOUN fnp-4496 127 34 rna rna NOUN fnp-4496 127 35 sequencing sequencing NOUN fnp-4496 127 36 . . PUNCT fnp-4496 128 1 our our PRON fnp-4496 128 2 results result NOUN fnp-4496 128 3 found find VERB fnp-4496 128 4 widespread widespread ADJ fnp-4496 128 5 changes change NOUN fnp-4496 128 6 in in ADP fnp-4496 128 7 ecm ecm NOUN fnp-4496 128 8 molecules molecule NOUN fnp-4496 128 9 and and CCONJ fnp-4496 128 10 their their PRON fnp-4496 128 11 interacting interact VERB fnp-4496 128 12 proteins protein NOUN fnp-4496 128 13 , , PUNCT fnp-4496 128 14 including include VERB fnp-4496 128 15 alterations alteration NOUN fnp-4496 128 16 to to ADP fnp-4496 128 17 proteoglycans proteoglycan NOUN fnp-4496 128 18 and and CCONJ fnp-4496 128 19 glycoproteins glycoprotein NOUN fnp-4496 128 20 within within ADP fnp-4496 128 21 inactive inactive ADJ fnp-4496 128 22 and and CCONJ fnp-4496 128 23 active active ADJ fnp-4496 128 24 ms ms ADJ fnp-4496 128 25 lesions lesion NOUN fnp-4496 128 26 . . PUNCT fnp-4496 129 1 some some DET fnp-4496 129 2 highly highly ADV fnp-4496 129 3 upregulated upregulated ADJ fnp-4496 129 4 members member NOUN fnp-4496 129 5 , , PUNCT fnp-4496 129 6 including include VERB fnp-4496 129 7 serglycin serglycin NOUN fnp-4496 129 8 and and CCONJ fnp-4496 129 9 sparc sparc NOUN fnp-4496 129 10 - - PUNCT fnp-4496 129 11 related relate VERB fnp-4496 129 12 proteins protein NOUN fnp-4496 129 13 , , PUNCT fnp-4496 129 14 have have AUX fnp-4496 129 15 not not PART fnp-4496 129 16 previously previously ADV fnp-4496 129 17 been be AUX fnp-4496 129 18 investigated investigate VERB fnp-4496 129 19 and and CCONJ fnp-4496 129 20 their their PRON fnp-4496 129 21 role role NOUN fnp-4496 129 22 on on ADP fnp-4496 129 23 ms ms ADJ fnp-4496 129 24 lesion lesion NOUN fnp-4496 129 25 evolution evolution NOUN fnp-4496 129 26 and and CCONJ fnp-4496 129 27 disease disease NOUN fnp-4496 129 28 course course NOUN fnp-4496 129 29 remains remain VERB fnp-4496 129 30 unknown unknown ADJ fnp-4496 129 31 . . PUNCT fnp-4496 130 1 our our PRON fnp-4496 130 2 results result NOUN fnp-4496 130 3 emphasize emphasize VERB fnp-4496 130 4 that that SCONJ fnp-4496 130 5 there there PRON fnp-4496 130 6 are be VERB fnp-4496 130 7 profound profound ADJ fnp-4496 130 8 changes change NOUN fnp-4496 130 9 to to ADP fnp-4496 130 10 the the DET fnp-4496 130 11 ecm ecm NOUN fnp-4496 130 12 following follow VERB fnp-4496 130 13 demyelination demyelination NOUN fnp-4496 130 14 . . PUNCT fnp-4496 130 15     SPACE fnp-4496 131 1 abstract abstract ADJ fnp-4496 131 2 13 13 NUM fnp-4496 131 3 free free ADJ fnp-4496 131 4 neuropathol neuropathol NOUN fnp-4496 131 5 3:25:16 3:25:16 NUM fnp-4496 131 6 nodding nodding NOUN fnp-4496 131 7 syndrome syndrome NOUN fnp-4496 131 8 : : PUNCT fnp-4496 131 9 characterizing characterize VERB fnp-4496 131 10 the the DET fnp-4496 131 11 newest new ADJ fnp-4496 131 12 tau tau NOUN fnp-4496 131 13 proteinopathy proteinopathy ADJ fnp-4496 131 14 in in ADP fnp-4496 131 15 africa africa PROPN fnp-4496 131 16 kenneth kenneth PROPN fnp-4496 131 17 g. g. PROPN fnp-4496 131 18 kodja1,2,3 kodja1,2,3 PROPN fnp-4496 131 19 , , PUNCT fnp-4496 131 20 sylvester sylvester PROPN fnp-4496 131 21 onzivua4 onzivua4 PROPN fnp-4496 131 22 , , PUNCT fnp-4496 131 23 david david PROPN fnp-4496 131 24 clutterbuck2 clutterbuck2 PROPN fnp-4496 131 25 , , PUNCT fnp-4496 131 26 david david PROPN fnp-4496 131 27 l. l. PROPN fnp-4496 131 28 kitara5 kitara5 PROPN fnp-4496 131 29 , , PUNCT fnp-4496 131 30 amanda amanda PROPN fnp-4496 131 31 fong2 fong2 PROPN fnp-4496 131 32 , , PUNCT fnp-4496 131 33 michael michael PROPN fnp-4496 131 34 s. s. PROPN fnp-4496 131 35 pollanen1,2,3 pollanen1,2,3 PROPN fnp-4496 131 36 1 1 NUM fnp-4496 131 37 department department NOUN fnp-4496 131 38 of of ADP fnp-4496 131 39 pathobiology pathobiology NOUN fnp-4496 131 40 and and CCONJ fnp-4496 131 41 laboratory laboratory NOUN fnp-4496 131 42 medicine medicine NOUN fnp-4496 131 43 , , PUNCT fnp-4496 131 44 university university PROPN fnp-4496 131 45 of of ADP fnp-4496 131 46 toronto toronto PROPN fnp-4496 131 47 , , PUNCT fnp-4496 131 48 toronto toronto PROPN fnp-4496 131 49 , , PUNCT fnp-4496 131 50 on on ADP fnp-4496 131 51 , , PUNCT fnp-4496 131 52 canada canada PROPN fnp-4496 131 53 2 2 NUM fnp-4496 131 54 ontario ontario PROPN fnp-4496 131 55 forensic forensic ADJ fnp-4496 131 56 pathology pathology NOUN fnp-4496 131 57 service service PROPN fnp-4496 131 58 , , PUNCT fnp-4496 131 59 toronto toronto PROPN fnp-4496 131 60 , , PUNCT fnp-4496 131 61 on on ADP fnp-4496 131 62 , , PUNCT fnp-4496 131 63 canada canada PROPN fnp-4496 131 64 3 3 NUM fnp-4496 131 65 tanz tanz PROPN fnp-4496 131 66 centre centre PROPN fnp-4496 131 67 for for ADP fnp-4496 131 68 research research NOUN fnp-4496 131 69 in in ADP fnp-4496 131 70 neurodegenerative neurodegenerative ADJ fnp-4496 131 71 diseases disease NOUN fnp-4496 131 72 , , PUNCT fnp-4496 131 73 university university NOUN fnp-4496 131 74 of of ADP fnp-4496 131 75 toronto toronto PROPN fnp-4496 131 76 , , PUNCT fnp-4496 131 77 toronto toronto PROPN fnp-4496 131 78 , , PUNCT fnp-4496 131 79 on on ADV fnp-4496 131 80 , , PUNCT fnp-4496 131 81 canada canada PROPN fnp-4496 131 82 4 4 NUM fnp-4496 131 83 department department PROPN fnp-4496 131 84 of of ADP fnp-4496 131 85 pathology pathology PROPN fnp-4496 131 86 , , PUNCT fnp-4496 131 87 college college PROPN fnp-4496 131 88 of of ADP fnp-4496 131 89 health health PROPN fnp-4496 131 90 sciences sciences PROPN fnp-4496 131 91 , , PUNCT fnp-4496 131 92 makerere makerere NOUN fnp-4496 131 93 university university NOUN fnp-4496 131 94 , , PUNCT fnp-4496 131 95 kampala kampala PROPN fnp-4496 131 96 , , PUNCT fnp-4496 131 97 uganda uganda PROPN fnp-4496 131 98 5 5 NUM fnp-4496 131 99 department department NOUN fnp-4496 131 100 of of ADP fnp-4496 131 101 surgery surgery NOUN fnp-4496 131 102 , , PUNCT fnp-4496 131 103 gulu gulu PROPN fnp-4496 131 104 university university NOUN fnp-4496 131 105 , , PUNCT fnp-4496 131 106 gulu gulu PROPN fnp-4496 131 107 , , PUNCT fnp-4496 131 108 uganda uganda PROPN fnp-4496 131 109 nodding nodding PROPN fnp-4496 131 110 syndrome syndrome PROPN fnp-4496 131 111 ( ( PUNCT fnp-4496 131 112 ns ns NUM fnp-4496 131 113 ) ) PUNCT fnp-4496 131 114 is be AUX fnp-4496 131 115 an an DET fnp-4496 131 116 acquired acquire VERB fnp-4496 131 117 tau tau NOUN fnp-4496 131 118 proteinopathy proteinopathy ADJ fnp-4496 131 119 plaguing plague VERB fnp-4496 131 120 the the DET fnp-4496 131 121 remote remote ADJ fnp-4496 131 122 rural rural ADJ fnp-4496 131 123 communities community NOUN fnp-4496 131 124 in in ADP fnp-4496 131 125 eastern eastern ADJ fnp-4496 131 126 sub sub ADJ fnp-4496 131 127 - - ADJ fnp-4496 131 128 saharan saharan ADJ fnp-4496 131 129 africa africa PROPN fnp-4496 131 130 . . PUNCT fnp-4496 132 1 it it PRON fnp-4496 132 2 has have AUX fnp-4496 132 3 been be AUX fnp-4496 132 4 proposed propose VERB fnp-4496 132 5 that that SCONJ fnp-4496 132 6 infection infection NOUN fnp-4496 132 7 with with ADP fnp-4496 132 8 the the DET fnp-4496 132 9 nematode nematode NOUN fnp-4496 132 10 parasite parasite NOUN fnp-4496 132 11 onchocerca onchocerca ADJ fnp-4496 132 12 volvulus volvulus NOUN fnp-4496 132 13 triggers trigger VERB fnp-4496 132 14 an an DET fnp-4496 132 15 autoimmune autoimmune ADJ fnp-4496 132 16 attack attack NOUN fnp-4496 132 17 against against ADP fnp-4496 132 18 the the DET fnp-4496 132 19 human human ADJ fnp-4496 132 20 protein protein NOUN fnp-4496 132 21 leiomodin-1 leiomodin-1 PROPN fnp-4496 132 22 . . PUNCT fnp-4496 133 1 this this DET fnp-4496 133 2 theory theory NOUN fnp-4496 133 3 is be AUX fnp-4496 133 4 dependent dependent ADJ fnp-4496 133 5 on on ADP fnp-4496 133 6 the the DET fnp-4496 133 7 constitutive constitutive ADJ fnp-4496 133 8 neuronal neuronal ADJ fnp-4496 133 9 expression expression NOUN fnp-4496 133 10 of of ADP fnp-4496 133 11 leiomodin-1 leiomodin-1 PROPN fnp-4496 133 12 . . PUNCT fnp-4496 134 1 we we PRON fnp-4496 134 2 tested test VERB fnp-4496 134 3 this this DET fnp-4496 134 4 hypothesis hypothesis NOUN fnp-4496 134 5 by by ADP fnp-4496 134 6 exploring explore VERB fnp-4496 134 7 the the DET fnp-4496 134 8 histologic histologic ADJ fnp-4496 134 9 distribution distribution NOUN fnp-4496 134 10 of of ADP fnp-4496 134 11 this this DET fnp-4496 134 12 protein protein NOUN fnp-4496 134 13 in in ADP fnp-4496 134 14 the the DET fnp-4496 134 15 normal normal ADJ fnp-4496 134 16 human human ADJ fnp-4496 134 17 brain brain NOUN fnp-4496 134 18 . . PUNCT fnp-4496 135 1 subsequent subsequent ADJ fnp-4496 135 2 immunostaining immunostaine VERB fnp-4496 135 3 of of ADP fnp-4496 135 4 cerebellar cerebellar ADJ fnp-4496 135 5 tissue tissue NOUN fnp-4496 135 6 and and CCONJ fnp-4496 135 7 c. c. NOUN fnp-4496 135 8 elegans elegan NOUN fnp-4496 135 9 ( ( PUNCT fnp-4496 135 10 a a DET fnp-4496 135 11 proxy proxy NOUN fnp-4496 135 12 for for ADP fnp-4496 135 13 onchocerca onchocerca ADJ fnp-4496 135 14 volvulus volvulus NOUN fnp-4496 135 15 ) ) PUNCT fnp-4496 135 16 using use VERB fnp-4496 135 17 an an DET fnp-4496 135 18 antibody antibody NOUN fnp-4496 135 19 recognizing recognize VERB fnp-4496 135 20 the the DET fnp-4496 135 21 n n NOUN fnp-4496 135 22 - - PUNCT fnp-4496 135 23 terminus terminus NOUN fnp-4496 135 24 of of ADP fnp-4496 135 25 leiomodin-1 leiomodin-1 PROPN fnp-4496 135 26 was be AUX fnp-4496 135 27 conducted conduct VERB fnp-4496 135 28 . . PUNCT fnp-4496 136 1 our our PRON fnp-4496 136 2 study study NOUN fnp-4496 136 3 failed fail VERB fnp-4496 136 4 to to PART fnp-4496 136 5 identify identify VERB fnp-4496 136 6 the the DET fnp-4496 136 7 presence presence NOUN fnp-4496 136 8 of of ADP fnp-4496 136 9 leiomodin-1 leiomodin-1 PROPN fnp-4496 136 10 immunoreactivity immunoreactivity NOUN fnp-4496 136 11 in in ADP fnp-4496 136 12 neurons neuron NOUN fnp-4496 136 13 or or CCONJ fnp-4496 136 14 glia glia NOUN fnp-4496 136 15 . . PUNCT fnp-4496 137 1 our our PRON fnp-4496 137 2 results result NOUN fnp-4496 137 3 also also ADV fnp-4496 137 4 suggest suggest VERB fnp-4496 137 5 the the DET fnp-4496 137 6 possibility possibility NOUN fnp-4496 137 7 of of ADP fnp-4496 137 8 leiomodin-1 leiomodin-1 NUM fnp-4496 137 9 antibody antibody NOUN fnp-4496 137 10 cross cross NOUN fnp-4496 137 11 - - NOUN fnp-4496 137 12 reactivity reactivity NOUN fnp-4496 137 13 between between ADP fnp-4496 137 14 human human PROPN fnp-4496 137 15 purkinje purkinje PROPN fnp-4496 137 16 cell cell NOUN fnp-4496 137 17 membranes membrane NOUN fnp-4496 137 18 and and CCONJ fnp-4496 137 19 the the DET fnp-4496 137 20 body body NOUN fnp-4496 137 21 wall wall NOUN fnp-4496 137 22 of of ADP fnp-4496 137 23 c. c. PROPN fnp-4496 137 24 elegans elegans PROPN fnp-4496 137 25 ; ; PUNCT fnp-4496 137 26 a a DET fnp-4496 137 27 finding finding NOUN fnp-4496 137 28 explained explain VERB fnp-4496 137 29 by by ADP fnp-4496 137 30 the the DET fnp-4496 137 31 homology homology NOUN fnp-4496 137 32 between between ADP fnp-4496 137 33 leiomodin-1 leiomodin-1 PROPN fnp-4496 137 34 and and CCONJ fnp-4496 137 35 tropomodulin tropomodulin PROPN fnp-4496 137 36 . . PUNCT fnp-4496 138 1 this this DET fnp-4496 138 2 outcome outcome NOUN fnp-4496 138 3 does do AUX fnp-4496 138 4 not not PART fnp-4496 138 5 support support VERB fnp-4496 138 6 the the DET fnp-4496 138 7 hypothesis hypothesis NOUN fnp-4496 138 8 of of ADP fnp-4496 138 9 autoimmunity autoimmunity NOUN fnp-4496 138 10 involving involve VERB fnp-4496 138 11 onchocerca onchocerca ADJ fnp-4496 138 12 volvulus volvulus NOUN fnp-4496 138 13 and and CCONJ fnp-4496 138 14 leiomodin-1 leiomodin-1 PROPN fnp-4496 138 15 . . X fnp-4496 139 1 we we PRON fnp-4496 139 2 also also ADV fnp-4496 139 3 investigate investigate VERB fnp-4496 139 4 the the DET fnp-4496 139 5 signature signature NOUN fnp-4496 139 6 laminar laminar ADJ fnp-4496 139 7 distribution distribution NOUN fnp-4496 139 8 of of ADP fnp-4496 139 9 cortical cortical ADJ fnp-4496 139 10 tau tau PROPN fnp-4496 139 11 pathology pathology NOUN fnp-4496 139 12 in in ADP fnp-4496 139 13 ns ns PROPN fnp-4496 139 14 . . PROPN fnp-4496 139 15 through through ADP fnp-4496 139 16 morphometric morphometric ADJ fnp-4496 139 17 analysis analysis NOUN fnp-4496 139 18 , , PUNCT fnp-4496 139 19 our our PRON fnp-4496 139 20 current current ADJ fnp-4496 139 21 study study NOUN fnp-4496 139 22 , , PUNCT fnp-4496 139 23 in in ADP fnp-4496 139 24 agreement agreement NOUN fnp-4496 139 25 with with ADP fnp-4496 139 26 the the DET fnp-4496 139 27 literature literature NOUN fnp-4496 139 28 , , PUNCT fnp-4496 139 29 suggests suggest VERB fnp-4496 139 30 that that SCONJ fnp-4496 139 31 primary primary ADJ fnp-4496 139 32 tauopathies tauopathie NOUN fnp-4496 139 33 ( ( PUNCT fnp-4496 139 34 the the DET fnp-4496 139 35 likes like NOUN fnp-4496 139 36 of of ADP fnp-4496 139 37 progressive progressive ADJ fnp-4496 139 38 supranuclear supranuclear ADJ fnp-4496 139 39 palsy palsy ADJ fnp-4496 139 40 , , PUNCT fnp-4496 139 41 corticobasal corticobasal NOUN fnp-4496 139 42 degeneration degeneration NOUN fnp-4496 139 43 , , PUNCT fnp-4496 139 44 pick pick VERB fnp-4496 139 45 ’s ’s PART fnp-4496 139 46 disease disease NOUN fnp-4496 139 47 and and CCONJ fnp-4496 139 48 globular globular ADJ fnp-4496 139 49 glial glial ADJ fnp-4496 139 50 tauopathy tauopathy NOUN fnp-4496 139 51 ) ) PUNCT fnp-4496 139 52 are be AUX fnp-4496 139 53 associated associate VERB fnp-4496 139 54 with with ADP fnp-4496 139 55 severe severe ADJ fnp-4496 139 56 lower low ADJ fnp-4496 139 57 layer layer NOUN fnp-4496 139 58 ( ( PUNCT fnp-4496 139 59 iv iv NOUN fnp-4496 139 60 - - PUNCT fnp-4496 139 61 vi vi NOUN fnp-4496 139 62 ) ) PUNCT fnp-4496 139 63 pathologic pathologic ADJ fnp-4496 139 64 burden burden NOUN fnp-4496 139 65 , , PUNCT fnp-4496 139 66 independent independent ADJ fnp-4496 139 67 of of ADP fnp-4496 139 68 clinical clinical ADJ fnp-4496 139 69 symptomology symptomology NOUN fnp-4496 139 70 . . PUNCT fnp-4496 140 1 interestingly interestingly ADV fnp-4496 140 2 , , PUNCT fnp-4496 140 3 we we PRON fnp-4496 140 4 found find VERB fnp-4496 140 5 predominant predominant ADJ fnp-4496 140 6 involvement involvement NOUN fnp-4496 140 7 of of ADP fnp-4496 140 8 the the DET fnp-4496 140 9 upper upper ADJ fnp-4496 140 10 layers layer NOUN fnp-4496 140 11 ( ( PUNCT fnp-4496 140 12 i i PROPN fnp-4496 140 13 - - PUNCT fnp-4496 140 14 iii iii NOUN fnp-4496 140 15 ) ) PUNCT fnp-4496 140 16 in in ADP fnp-4496 140 17 ns ns NUM fnp-4496 140 18 ; ; PUNCT fnp-4496 140 19 a a DET fnp-4496 140 20 laminar laminar ADJ fnp-4496 140 21 profile profile NOUN fnp-4496 140 22 similar similar ADJ fnp-4496 140 23 to to ADP fnp-4496 140 24 the the DET fnp-4496 140 25 amyotrophic amyotrophic ADJ fnp-4496 140 26 lateral lateral ADJ fnp-4496 140 27 sclerosis sclerosis NOUN fnp-4496 140 28 and and CCONJ fnp-4496 140 29 parkinsonism parkinsonism NOUN fnp-4496 140 30 - - PUNCT fnp-4496 140 31 dementia dementia NOUN fnp-4496 140 32 complex complex NOUN fnp-4496 140 33 of of ADP fnp-4496 140 34 guam guam PROPN fnp-4496 140 35 . . PUNCT fnp-4496 141 1 the the DET fnp-4496 141 2 present present ADJ fnp-4496 141 3 study study NOUN fnp-4496 141 4 lays lay VERB fnp-4496 141 5 the the DET fnp-4496 141 6 foundation foundation NOUN fnp-4496 141 7 for for ADP fnp-4496 141 8 future future ADJ fnp-4496 141 9 work work NOUN fnp-4496 141 10 investigating investigate VERB fnp-4496 141 11 potentially potentially ADV fnp-4496 141 12 unique unique ADJ fnp-4496 141 13 mechanisms mechanism NOUN fnp-4496 141 14 of of ADP fnp-4496 141 15 propagation propagation NOUN fnp-4496 141 16 and and CCONJ fnp-4496 141 17 neurodegeneration neurodegeneration NOUN fnp-4496 141 18 in in ADP fnp-4496 141 19 ns ns PROPN fnp-4496 141 20 . . PUNCT fnp-4496 141 21     SPACE fnp-4496 141 22 abstract abstract ADJ fnp-4496 141 23 14 14 NUM fnp-4496 141 24 free free ADJ fnp-4496 141 25 neuropathol neuropathol NOUN fnp-4496 141 26 3:25:17 3:25:17 NUM fnp-4496 141 27 mri mri ADJ fnp-4496 141 28 - - PUNCT fnp-4496 141 29 pathological pathological ADJ fnp-4496 141 30 correlations correlation NOUN fnp-4496 141 31 show show VERB fnp-4496 141 32 differential differential ADJ fnp-4496 141 33 patterns pattern NOUN fnp-4496 141 34 of of ADP fnp-4496 141 35 ex ex PRON fnp-4496 141 36 vivo vivo ADJ fnp-4496 141 37 texture texture NOUN fnp-4496 141 38 in in ADP fnp-4496 141 39 als als NOUN fnp-4496 141 40 avyarthana avyarthana PROPN fnp-4496 141 41 dey1,2 dey1,2 PROPN fnp-4496 141 42 , , PUNCT fnp-4496 141 43 collin collin PROPN fnp-4496 141 44 luk2 luk2 PROPN fnp-4496 141 45 , , PUNCT fnp-4496 141 46 abdullah abdullah PROPN fnp-4496 141 47 ishaque1,2 ishaque1,2 PROPN fnp-4496 141 48 , , PUNCT fnp-4496 141 49 peter peter PROPN fnp-4496 141 50 seres3 seres3 PROPN fnp-4496 141 51 , , PUNCT fnp-4496 141 52 dennell dennell PROPN fnp-4496 141 53 krebs2 krebs2 PROPN fnp-4496 141 54 , , PUNCT fnp-4496 141 55 yee yee PROPN fnp-4496 141 56 - - PUNCT fnp-4496 141 57 hong hong PROPN fnp-4496 141 58 yang4 yang4 PROPN fnp-4496 141 59 , , PUNCT fnp-4496 141 60 julia julia PROPN fnp-4496 141 61 keith5,6 keith5,6 PROPN fnp-4496 141 62 , , PUNCT fnp-4496 141 63 sumit sumit PROPN fnp-4496 141 64 das1,7 das1,7 PROPN fnp-4496 141 65 , , PUNCT fnp-4496 141 66 ekaterina ekaterina PROPN fnp-4496 141 67 olkhov olkhov PROPN fnp-4496 141 68 - - PUNCT fnp-4496 141 69 mitsel5 mitsel5 PROPN fnp-4496 141 70 , , PUNCT fnp-4496 141 71 sanjay sanjay ADJ fnp-4496 141 72 kalra1,2 kalra1,2 PROPN fnp-4496 141 73 1 1 NUM fnp-4496 141 74 neuroscience neuroscience NOUN fnp-4496 141 75 and and CCONJ fnp-4496 141 76 mental mental ADJ fnp-4496 141 77 health health PROPN fnp-4496 141 78 institute institute PROPN fnp-4496 141 79 , , PUNCT fnp-4496 141 80 university university PROPN fnp-4496 141 81 of of ADP fnp-4496 141 82 alberta alberta PROPN fnp-4496 141 83 , , PUNCT fnp-4496 141 84 edmonton edmonton PROPN fnp-4496 141 85 , , PUNCT fnp-4496 141 86 ab ab PROPN fnp-4496 141 87 , , PUNCT fnp-4496 141 88 canada canada PROPN fnp-4496 141 89 2 2 NUM fnp-4496 141 90 division division NOUN fnp-4496 141 91 of of ADP fnp-4496 141 92 neurology neurology NOUN fnp-4496 141 93 , , PUNCT fnp-4496 141 94 faculty faculty NOUN fnp-4496 141 95 of of ADP fnp-4496 141 96 medicine medicine NOUN fnp-4496 141 97 and and CCONJ fnp-4496 141 98 dentistry dentistry NOUN fnp-4496 141 99 , , PUNCT fnp-4496 141 100 university university PROPN fnp-4496 141 101 of of ADP fnp-4496 141 102 alberta alberta PROPN fnp-4496 141 103 , , PUNCT fnp-4496 141 104 edmonton edmonton PROPN fnp-4496 141 105 , , PUNCT fnp-4496 141 106 ab ab PROPN fnp-4496 141 107 , , PUNCT fnp-4496 141 108 canada canada PROPN fnp-4496 141 109 3 3 NUM fnp-4496 141 110 peter peter PROPN fnp-4496 141 111 s. s. PROPN fnp-4496 141 112 allen allen PROPN fnp-4496 141 113 mri mri PROPN fnp-4496 141 114 center center PROPN fnp-4496 141 115 , , PUNCT fnp-4496 141 116 university university PROPN fnp-4496 141 117 of of ADP fnp-4496 141 118 alberta alberta PROPN fnp-4496 141 119 , , PUNCT fnp-4496 141 120 edmonton edmonton PROPN fnp-4496 141 121 , , PUNCT fnp-4496 141 122 ab ab PROPN fnp-4496 141 123 , , PUNCT fnp-4496 141 124 canada canada PROPN fnp-4496 141 125 4 4 NUM fnp-4496 141 126 faculty faculty NOUN fnp-4496 141 127 of of ADP fnp-4496 141 128 science science NOUN fnp-4496 141 129 – – PUNCT fnp-4496 141 130 computing compute VERB fnp-4496 141 131 science science NOUN fnp-4496 141 132 , , PUNCT fnp-4496 141 133 university university PROPN fnp-4496 141 134 of of ADP fnp-4496 141 135 alberta alberta PROPN fnp-4496 141 136 , , PUNCT fnp-4496 141 137 edmonton edmonton PROPN fnp-4496 141 138 , , PUNCT fnp-4496 141 139 ab ab PROPN fnp-4496 141 140 , , PUNCT fnp-4496 141 141 canada canada PROPN fnp-4496 141 142 5 5 NUM fnp-4496 141 143 laboratory laboratory NOUN fnp-4496 141 144 medicine medicine NOUN fnp-4496 141 145 and and CCONJ fnp-4496 141 146 molecular molecular ADJ fnp-4496 141 147 diagnostics diagnostic NOUN fnp-4496 141 148 , , PUNCT fnp-4496 141 149 sunnybrook sunnybrook PROPN fnp-4496 141 150 health health PROPN fnp-4496 141 151 sciences sciences PROPN fnp-4496 141 152 centre centre PROPN fnp-4496 141 153 , , PUNCT fnp-4496 141 154 toronto toronto PROPN fnp-4496 141 155 , , PUNCT fnp-4496 141 156 on on ADP fnp-4496 141 157 , , PUNCT fnp-4496 141 158 canada canada PROPN fnp-4496 141 159 6 6 NUM fnp-4496 141 160 department department NOUN fnp-4496 141 161 of of ADP fnp-4496 141 162 laboratory laboratory PROPN fnp-4496 141 163 medicine medicine PROPN fnp-4496 141 164 & & CCONJ fnp-4496 141 165 pathobiology pathobiology NOUN fnp-4496 141 166 , , PUNCT fnp-4496 141 167 university university PROPN fnp-4496 141 168 of of ADP fnp-4496 141 169 toronto toronto PROPN fnp-4496 141 170 , , PUNCT fnp-4496 141 171 toronto toronto PROPN fnp-4496 141 172 , , PUNCT fnp-4496 141 173 on on ADP fnp-4496 141 174 , , PUNCT fnp-4496 141 175 canada canada PROPN fnp-4496 141 176 7 7 NUM fnp-4496 141 177 department department PROPN fnp-4496 141 178 of of ADP fnp-4496 141 179 laboratory laboratory PROPN fnp-4496 141 180 medicine medicine PROPN fnp-4496 141 181 & & CCONJ fnp-4496 141 182 pathology pathology PROPN fnp-4496 141 183 , , PUNCT fnp-4496 141 184 faculty faculty NOUN fnp-4496 141 185 of of ADP fnp-4496 141 186 medicine medicine NOUN fnp-4496 141 187 and and CCONJ fnp-4496 141 188 dentistry dentistry NOUN fnp-4496 141 189 , , PUNCT fnp-4496 141 190 university university PROPN fnp-4496 141 191 of of ADP fnp-4496 141 192 alberta alberta PROPN fnp-4496 141 193 , , PUNCT fnp-4496 141 194 edmonton edmonton PROPN fnp-4496 141 195 , , PUNCT fnp-4496 141 196 ab ab PROPN fnp-4496 141 197 , , PUNCT fnp-4496 141 198 canada canada PROPN fnp-4496 141 199 in in ADP fnp-4496 141 200 vivo vivo ADJ fnp-4496 141 201 magnetic magnetic ADJ fnp-4496 141 202 resonance resonance NOUN fnp-4496 141 203 imaging imaging NOUN fnp-4496 141 204 ( ( PUNCT fnp-4496 141 205 mri mri NOUN fnp-4496 141 206 ) ) PUNCT fnp-4496 141 207 has have AUX fnp-4496 141 208 provided provide VERB fnp-4496 141 209 a a DET fnp-4496 141 210 reliable reliable ADJ fnp-4496 141 211 biomarker biomarker NOUN fnp-4496 141 212 for for ADP fnp-4496 141 213 amyotrophic amyotrophic ADJ fnp-4496 141 214 lateral lateral ADJ fnp-4496 141 215 sclerosis sclerosis NOUN fnp-4496 141 216 ( ( PUNCT fnp-4496 141 217 als als NOUN fnp-4496 141 218 ) ) PUNCT fnp-4496 141 219 . . PUNCT fnp-4496 142 1 however however ADV fnp-4496 142 2 , , PUNCT fnp-4496 142 3 lack lack NOUN fnp-4496 142 4 of of ADP fnp-4496 142 5 pathological pathological ADJ fnp-4496 142 6 specificity specificity NOUN fnp-4496 142 7 of of ADP fnp-4496 142 8 these these DET fnp-4496 142 9 biomarkers biomarker NOUN fnp-4496 142 10 impedes impede VERB fnp-4496 142 11 their their PRON fnp-4496 142 12 integration integration NOUN fnp-4496 142 13 in in ADP fnp-4496 142 14 clinical clinical ADJ fnp-4496 142 15 investigations investigation NOUN fnp-4496 142 16 . . PUNCT fnp-4496 143 1 to to PART fnp-4496 143 2 address address VERB fnp-4496 143 3 this this DET fnp-4496 143 4 lack lack NOUN fnp-4496 143 5 of of ADP fnp-4496 143 6 specificity specificity NOUN fnp-4496 143 7 and and CCONJ fnp-4496 143 8 establish establish VERB fnp-4496 143 9 their their PRON fnp-4496 143 10 relationship relationship NOUN fnp-4496 143 11 with with ADP fnp-4496 143 12 disease disease NOUN fnp-4496 143 13 pathology pathology NOUN fnp-4496 143 14 , , PUNCT fnp-4496 143 15 the the DET fnp-4496 143 16 aim aim NOUN fnp-4496 143 17 of of ADP fnp-4496 143 18 the the DET fnp-4496 143 19 current current ADJ fnp-4496 143 20 study study NOUN fnp-4496 143 21 was be AUX fnp-4496 143 22 to to PART fnp-4496 143 23 examine examine VERB fnp-4496 143 24 the the DET fnp-4496 143 25 associations association NOUN fnp-4496 143 26 between between ADP fnp-4496 143 27 ex ex PRON fnp-4496 143 28 vivo vivo NOUN fnp-4496 143 29 neuroimaging neuroimaging NOUN fnp-4496 143 30 and and CCONJ fnp-4496 143 31 histopathological histopathological ADJ fnp-4496 143 32 features feature NOUN fnp-4496 143 33 . . PUNCT fnp-4496 144 1 we we PRON fnp-4496 144 2 hypothesized hypothesize VERB fnp-4496 144 3 that that DET fnp-4496 144 4 histopathology histopathology NOUN fnp-4496 144 5 of of ADP fnp-4496 144 6 the the DET fnp-4496 144 7 cervical cervical ADJ fnp-4496 144 8 spinal spinal NOUN fnp-4496 144 9 cord cord NOUN fnp-4496 144 10 ( ( PUNCT fnp-4496 144 11 csc csc PROPN fnp-4496 144 12 ) ) PUNCT fnp-4496 144 13 and and CCONJ fnp-4496 144 14 precentral precentral ADJ fnp-4496 144 15 gyrus gyrus NOUN fnp-4496 144 16 ( ( PUNCT fnp-4496 144 17 pcg pcg PROPN fnp-4496 144 18 ) ) PUNCT fnp-4496 144 19 shows show VERB fnp-4496 144 20 associations association NOUN fnp-4496 144 21 with with ADP fnp-4496 144 22 texture texture NOUN fnp-4496 144 23 of of ADP fnp-4496 144 24 the the DET fnp-4496 144 25 posterior posterior ADJ fnp-4496 144 26 limb limb NOUN fnp-4496 144 27 of of ADP fnp-4496 144 28 internal internal ADJ fnp-4496 144 29 capsule capsule NOUN fnp-4496 144 30 ( ( PUNCT fnp-4496 144 31 plic plic NOUN fnp-4496 144 32 ) ) PUNCT fnp-4496 144 33 . . PUNCT fnp-4496 145 1 formalin formalin NOUN fnp-4496 145 2 - - PUNCT fnp-4496 145 3 fixed fix VERB fnp-4496 145 4 brains brain NOUN fnp-4496 145 5 of of ADP fnp-4496 145 6 13 13 NUM fnp-4496 145 7 als als NOUN fnp-4496 145 8 patients patient NOUN fnp-4496 145 9 underwent undergo VERB fnp-4496 145 10 excision excision NOUN fnp-4496 145 11 of of ADP fnp-4496 145 12 the the DET fnp-4496 145 13 pcg pcg PROPN fnp-4496 145 14 , , PUNCT fnp-4496 145 15 plic plic NOUN fnp-4496 145 16 , , PUNCT fnp-4496 145 17 and and CCONJ fnp-4496 145 18 csc csc PROPN fnp-4496 145 19 . . PROPN fnp-4496 145 20 t1 t1 PROPN fnp-4496 145 21 - - PUNCT fnp-4496 145 22 weighted weight VERB fnp-4496 145 23 mri mri NOUN fnp-4496 145 24 was be AUX fnp-4496 145 25 performed perform VERB fnp-4496 145 26 for for ADP fnp-4496 145 27 pcg pcg PROPN fnp-4496 145 28 and and CCONJ fnp-4496 145 29 plic plic NOUN fnp-4496 145 30 from from ADP fnp-4496 145 31 which which PRON fnp-4496 145 32 texture texture NOUN fnp-4496 145 33 features feature VERB fnp-4496 145 34 – – PUNCT fnp-4496 145 35 namely namely ADV fnp-4496 145 36 autocorrelation autocorrelation NOUN fnp-4496 145 37 ( ( PUNCT fnp-4496 145 38 autoc autoc NOUN fnp-4496 145 39 ) ) PUNCT fnp-4496 145 40 , , PUNCT fnp-4496 145 41 energy energy NOUN fnp-4496 145 42 ( ( PUNCT fnp-4496 145 43 energ energ PROPN fnp-4496 145 44 ) ) PUNCT fnp-4496 145 45 , , PUNCT fnp-4496 145 46 inverse inverse ADJ fnp-4496 145 47 difference difference NOUN fnp-4496 145 48 normalized normalize VERB fnp-4496 145 49 ( ( PUNCT fnp-4496 145 50 indnc indnc NOUN fnp-4496 145 51 ) ) PUNCT fnp-4496 145 52 – – PUNCT fnp-4496 145 53 were be AUX fnp-4496 145 54 extracted extract VERB fnp-4496 145 55 . . PUNCT fnp-4496 146 1 quantitative quantitative ADJ fnp-4496 146 2 histological histological ADJ fnp-4496 146 3 assessments assessment NOUN fnp-4496 146 4 were be AUX fnp-4496 146 5 performed perform VERB fnp-4496 146 6 using use VERB fnp-4496 146 7 qupath qupath NOUN fnp-4496 146 8 to to PART fnp-4496 146 9 assess assess VERB fnp-4496 146 10 the the DET fnp-4496 146 11 density density NOUN fnp-4496 146 12 of of ADP fnp-4496 146 13 axons axon NOUN fnp-4496 146 14 in in ADP fnp-4496 146 15 the the DET fnp-4496 146 16 corticospinal corticospinal ADJ fnp-4496 146 17 tract tract NOUN fnp-4496 146 18 on on ADP fnp-4496 146 19 nf nf ADJ fnp-4496 146 20 immunolabeling immunolabeling NOUN fnp-4496 146 21 , , PUNCT fnp-4496 146 22 and and CCONJ fnp-4496 146 23 extent extent NOUN fnp-4496 146 24 of of ADP fnp-4496 146 25 macrophage macrophage ADJ fnp-4496 146 26 infiltration infiltration NOUN fnp-4496 146 27 of of ADP fnp-4496 146 28 the the DET fnp-4496 146 29 corticospinal corticospinal ADJ fnp-4496 146 30 tract tract NOUN fnp-4496 146 31 on on ADP fnp-4496 146 32 cd68 cd68 PROPN fnp-4496 146 33 immunolabeling immunolabele VERB fnp-4496 146 34 in in ADP fnp-4496 146 35 the the DET fnp-4496 146 36 csc csc PROPN fnp-4496 146 37 . . PROPN fnp-4496 146 38 qualitative qualitative ADJ fnp-4496 146 39 assessments assessment NOUN fnp-4496 146 40 were be AUX fnp-4496 146 41 performed perform VERB fnp-4496 146 42 to to PART fnp-4496 146 43 assess assess VERB fnp-4496 146 44 superficial superficial ADJ fnp-4496 146 45 spongiosis spongiosis NOUN fnp-4496 146 46 and and CCONJ fnp-4496 146 47 presence presence NOUN fnp-4496 146 48 of of ADP fnp-4496 146 49 tdp-43 tdp-43 NOUN fnp-4496 146 50 inclusions inclusion NOUN fnp-4496 146 51 in in ADP fnp-4496 146 52 the the DET fnp-4496 146 53 pcg pcg PROPN fnp-4496 146 54 . . PUNCT fnp-4496 147 1 pearson’s pearson’s NOUN fnp-4496 147 2 - - PUNCT fnp-4496 147 3 r r NOUN fnp-4496 147 4 correlational correlational ADJ fnp-4496 147 5 analysis analysis NOUN fnp-4496 147 6 was be AUX fnp-4496 147 7 performed perform VERB fnp-4496 147 8 between between ADP fnp-4496 147 9 texture texture NOUN fnp-4496 147 10 and and CCONJ fnp-4496 147 11 histological histological ADJ fnp-4496 147 12 features feature NOUN fnp-4496 147 13 . . PUNCT fnp-4496 148 1 statistical statistical ADJ fnp-4496 148 2 significance significance NOUN fnp-4496 148 3 was be AUX fnp-4496 148 4 set set VERB fnp-4496 148 5 at at ADP fnp-4496 148 6 p p NOUN fnp-4496 148 7 < < X fnp-4496 148 8 0.05 0.05 NUM fnp-4496 148 9 . . PUNCT fnp-4496 149 1 a a DET fnp-4496 149 2 negative negative ADJ fnp-4496 149 3 correlation correlation NOUN fnp-4496 149 4 was be AUX fnp-4496 149 5 observed observe VERB fnp-4496 149 6 between between ADP fnp-4496 149 7 plic plic NOUN fnp-4496 149 8 autoc autoc NOUN fnp-4496 149 9 and and CCONJ fnp-4496 149 10 presence presence NOUN fnp-4496 149 11 of of ADP fnp-4496 149 12 tdp-43 tdp-43 NOUN fnp-4496 149 13 inclusions inclusion NOUN fnp-4496 149 14 ( ( PUNCT fnp-4496 149 15 r r NOUN fnp-4496 149 16 = = SYM fnp-4496 149 17 -0.652 -0.652 PROPN fnp-4496 149 18 , , PUNCT fnp-4496 149 19 p p NOUN fnp-4496 149 20 = = NOUN fnp-4496 149 21 0.022 0.022 NUM fnp-4496 149 22 ) ) PUNCT fnp-4496 149 23 as as ADV fnp-4496 149 24 well well ADV fnp-4496 149 25 as as ADP fnp-4496 149 26 superficial superficial ADJ fnp-4496 149 27 spongiosis spongiosis NOUN fnp-4496 149 28 ( ( PUNCT fnp-4496 149 29 r r NOUN fnp-4496 149 30 = = SYM fnp-4496 149 31 -0.585 -0.585 X fnp-4496 149 32 , , PUNCT fnp-4496 149 33 p p X fnp-4496 149 34 = = NOUN fnp-4496 149 35 0.046 0.046 NUM fnp-4496 149 36 ) ) PUNCT fnp-4496 149 37 in in ADP fnp-4496 149 38 the the DET fnp-4496 149 39 pcg pcg PROPN fnp-4496 149 40 . . PUNCT fnp-4496 150 1 a a DET fnp-4496 150 2 positive positive ADJ fnp-4496 150 3 correlation correlation NOUN fnp-4496 150 4 was be AUX fnp-4496 150 5 observed observe VERB fnp-4496 150 6 between between ADP fnp-4496 150 7 plic plic NOUN fnp-4496 150 8 energ energ NOUN fnp-4496 150 9 and and CCONJ fnp-4496 150 10 cd68 cd68 PROPN fnp-4496 150 11 density density NOUN fnp-4496 150 12 ( ( PUNCT fnp-4496 150 13 r r NOUN fnp-4496 150 14 = = SYM fnp-4496 150 15 0.714 0.714 NUM fnp-4496 150 16 , , PUNCT fnp-4496 150 17 p p X fnp-4496 150 18 = = NOUN fnp-4496 150 19 0.009 0.009 NUM fnp-4496 150 20 ) ) PUNCT fnp-4496 150 21 . . PUNCT fnp-4496 151 1 the the DET fnp-4496 151 2 pcg pcg PROPN fnp-4496 151 3 and and CCONJ fnp-4496 151 4 csc csc PROPN fnp-4496 151 5 demonstrate demonstrate NOUN fnp-4496 151 6 patterns pattern NOUN fnp-4496 151 7 of of ADP fnp-4496 151 8 histopathological histopathological ADJ fnp-4496 151 9 changes change NOUN fnp-4496 151 10 associated associate VERB fnp-4496 151 11 with with ADP fnp-4496 151 12 plic plic ADJ fnp-4496 151 13 texture texture NOUN fnp-4496 151 14 features feature NOUN fnp-4496 151 15 in in ADP fnp-4496 151 16 als al NOUN fnp-4496 151 17 . . PUNCT fnp-4496 151 18     SPACE fnp-4496 151 19 abstract abstract ADJ fnp-4496 151 20 15 15 NUM fnp-4496 151 21 free free ADJ fnp-4496 151 22 neuropathol neuropathol NOUN fnp-4496 151 23 3:25:18 3:25:18 NUM fnp-4496 151 24 lymphoid lymphoid NOUN fnp-4496 151 25 and and CCONJ fnp-4496 151 26 plasma plasma NOUN fnp-4496 151 27 - - PUNCT fnp-4496 151 28 cell cell NOUN fnp-4496 151 29 infiltrates infiltrate NOUN fnp-4496 151 30 with with ADP fnp-4496 151 31 amorphous amorphous ADJ fnp-4496 151 32 eosinophilic eosinophilic ADJ fnp-4496 151 33 material material NOUN fnp-4496 151 34 deposition deposition NOUN fnp-4496 151 35 in in ADP fnp-4496 151 36 the the DET fnp-4496 151 37 leptomeninges leptomeninge NOUN fnp-4496 151 38 : : PUNCT fnp-4496 151 39 a a DET fnp-4496 151 40 challenging challenging ADJ fnp-4496 151 41 case case NOUN fnp-4496 151 42 gianluca gianluca PROPN fnp-4496 151 43 lopez1,2 lopez1,2 PROPN fnp-4496 151 44 , , PUNCT fnp-4496 151 45 karam karam PROPN fnp-4496 151 46 han1 han1 PROPN fnp-4496 151 47 , , PUNCT fnp-4496 151 48 shino shino PROPN fnp-4496 151 49 d. d. PROPN fnp-4496 151 50 magaki1 magaki1 PROPN fnp-4496 151 51 , , PUNCT fnp-4496 151 52 sophie sophie PROPN fnp-4496 151 53 x. x. PROPN fnp-4496 151 54 song3 song3 PROPN fnp-4496 151 55 , , PUNCT fnp-4496 151 56 noriko noriko PROPN fnp-4496 151 57 salamon4 salamon4 PROPN fnp-4496 151 58 , , PUNCT fnp-4496 151 59 kanwarpal kanwarpal PROPN fnp-4496 151 60 s. s. PROPN fnp-4496 151 61 kahlon5 kahlon5 PROPN fnp-4496 151 62 , , PUNCT fnp-4496 151 63 inna inna PROPN fnp-4496 151 64 keselman6 keselman6 PROPN fnp-4496 151 65 , , PUNCT fnp-4496 151 66 ausaf ausaf PROPN fnp-4496 151 67 a. a. NOUN fnp-4496 151 68 bari7 bari7 PROPN fnp-4496 151 69 , , PUNCT fnp-4496 151 70 harry harry PROPN fnp-4496 151 71 v. v. PROPN fnp-4496 151 72 vinters1 vinters1 PROPN fnp-4496 151 73 1 1 NUM fnp-4496 151 74 section section NOUN fnp-4496 151 75 of of ADP fnp-4496 151 76 neuropathology neuropathology NOUN fnp-4496 151 77 , , PUNCT fnp-4496 151 78 department department NOUN fnp-4496 151 79 of of ADP fnp-4496 151 80 pathology pathology PROPN fnp-4496 151 81 and and CCONJ fnp-4496 151 82 laboratory laboratory NOUN fnp-4496 151 83 medicine medicine NOUN fnp-4496 151 84 , , PUNCT fnp-4496 151 85 ronald ronald PROPN fnp-4496 151 86 reagan reagan PROPN fnp-4496 151 87 ucla ucla PROPN fnp-4496 151 88 medical medical PROPN fnp-4496 151 89 center center PROPN fnp-4496 151 90 and and CCONJ fnp-4496 151 91 david david PROPN fnp-4496 151 92 geffen geffen PROPN fnp-4496 151 93 school school PROPN fnp-4496 151 94 of of ADP fnp-4496 151 95 medicine medicine NOUN fnp-4496 151 96 , , PUNCT fnp-4496 151 97 los los PROPN fnp-4496 151 98 angeles angeles PROPN fnp-4496 151 99 , , PUNCT fnp-4496 151 100 ca ca PROPN fnp-4496 151 101 , , PUNCT fnp-4496 151 102 usa usa PROPN fnp-4496 151 103 2 2 NUM fnp-4496 151 104 university university PROPN fnp-4496 151 105 of of ADP fnp-4496 151 106 milan milan PROPN fnp-4496 151 107 , , PUNCT fnp-4496 151 108 milan milan PROPN fnp-4496 151 109 , , PUNCT fnp-4496 151 110 italy italy PROPN fnp-4496 151 111 3 3 NUM fnp-4496 151 112 section section NOUN fnp-4496 151 113 of of ADP fnp-4496 151 114 hematopathology hematopathology NOUN fnp-4496 151 115 , , PUNCT fnp-4496 151 116 department department NOUN fnp-4496 151 117 of of ADP fnp-4496 151 118 pathology pathology PROPN fnp-4496 151 119 and and CCONJ fnp-4496 151 120 laboratory laboratory NOUN fnp-4496 151 121 medicine medicine NOUN fnp-4496 151 122 , , PUNCT fnp-4496 151 123 ronald ronald PROPN fnp-4496 151 124 reagan reagan PROPN fnp-4496 151 125 ucla ucla PROPN fnp-4496 151 126 medical medical PROPN fnp-4496 151 127 center center PROPN fnp-4496 151 128 and and CCONJ fnp-4496 151 129 david david PROPN fnp-4496 151 130 geffen geffen PROPN fnp-4496 151 131 school school PROPN fnp-4496 151 132 of of ADP fnp-4496 151 133 medicine medicine NOUN fnp-4496 151 134 , , PUNCT fnp-4496 151 135 los los PROPN fnp-4496 151 136 angeles angeles PROPN fnp-4496 151 137 , , PUNCT fnp-4496 151 138 ca ca PROPN fnp-4496 151 139 , , PUNCT fnp-4496 151 140 usa usa PROPN fnp-4496 151 141 4 4 NUM fnp-4496 151 142 department department NOUN fnp-4496 151 143 of of ADP fnp-4496 151 144 radiology radiology NOUN fnp-4496 151 145 , , PUNCT fnp-4496 151 146 david david PROPN fnp-4496 151 147 geffen geffen PROPN fnp-4496 151 148 school school PROPN fnp-4496 151 149 of of ADP fnp-4496 151 150 medicine medicine NOUN fnp-4496 151 151 , , PUNCT fnp-4496 151 152 university university PROPN fnp-4496 151 153 of of ADP fnp-4496 151 154 california california PROPN fnp-4496 151 155 , , PUNCT fnp-4496 151 156 los los PROPN fnp-4496 151 157 angeles angeles PROPN fnp-4496 151 158 , , PUNCT fnp-4496 151 159 los los PROPN fnp-4496 151 160 angeles angeles PROPN fnp-4496 151 161 , , PUNCT fnp-4496 151 162 ca ca PROPN fnp-4496 151 163 , , PUNCT fnp-4496 151 164 usa usa PROPN fnp-4496 151 165 5 5 NUM fnp-4496 151 166 division division NOUN fnp-4496 151 167 of of ADP fnp-4496 151 168 hematology hematology NOUN fnp-4496 151 169 - - PUNCT fnp-4496 151 170 oncology oncology NOUN fnp-4496 151 171 , , PUNCT fnp-4496 151 172 david david PROPN fnp-4496 151 173 geffen geffen PROPN fnp-4496 151 174 school school PROPN fnp-4496 151 175 of of ADP fnp-4496 151 176 medicine medicine NOUN fnp-4496 151 177 , , PUNCT fnp-4496 151 178 university university PROPN fnp-4496 151 179 of of ADP fnp-4496 151 180 california california PROPN fnp-4496 151 181 , , PUNCT fnp-4496 151 182 los los PROPN fnp-4496 151 183 angeles angeles PROPN fnp-4496 151 184 , , PUNCT fnp-4496 151 185 los los PROPN fnp-4496 151 186 angeles angeles PROPN fnp-4496 151 187 , , PUNCT fnp-4496 151 188 ca ca PROPN fnp-4496 151 189 , , PUNCT fnp-4496 151 190 usa usa PROPN fnp-4496 151 191 6 6 NUM fnp-4496 151 192 department department NOUN fnp-4496 151 193 of of ADP fnp-4496 151 194 neurology neurology NOUN fnp-4496 151 195 , , PUNCT fnp-4496 151 196 david david PROPN fnp-4496 151 197 geffen geffen PROPN fnp-4496 151 198 school school PROPN fnp-4496 151 199 of of ADP fnp-4496 151 200 medicine medicine NOUN fnp-4496 151 201 , , PUNCT fnp-4496 151 202 university university PROPN fnp-4496 151 203 of of ADP fnp-4496 151 204 california california PROPN fnp-4496 151 205 , , PUNCT fnp-4496 151 206 los los PROPN fnp-4496 151 207 angeles angeles PROPN fnp-4496 151 208 , , PUNCT fnp-4496 151 209 los los PROPN fnp-4496 151 210 angeles angeles PROPN fnp-4496 151 211 , , PUNCT fnp-4496 151 212 ca ca PROPN fnp-4496 151 213 , , PUNCT fnp-4496 151 214 usa usa PROPN fnp-4496 151 215 7 7 NUM fnp-4496 151 216 department department NOUN fnp-4496 151 217 of of ADP fnp-4496 151 218 neurosurgery neurosurgery NOUN fnp-4496 151 219 , , PUNCT fnp-4496 151 220 david david PROPN fnp-4496 151 221 geffen geffen PROPN fnp-4496 151 222 school school PROPN fnp-4496 151 223 of of ADP fnp-4496 151 224 medicine medicine NOUN fnp-4496 151 225 , , PUNCT fnp-4496 151 226 los los PROPN fnp-4496 151 227 angeles angeles PROPN fnp-4496 151 228 , , PUNCT fnp-4496 151 229 ca ca PROPN fnp-4496 151 230 , , PUNCT fnp-4496 151 231 usa usa PROPN fnp-4496 151 232 a a DET fnp-4496 151 233 65 65 NUM fnp-4496 151 234 - - PUNCT fnp-4496 151 235 year year NOUN fnp-4496 151 236 - - PUNCT fnp-4496 151 237 old old ADJ fnp-4496 151 238 female female NOUN fnp-4496 151 239 presented present VERB fnp-4496 151 240 with with ADP fnp-4496 151 241 recurrent recurrent ADJ fnp-4496 151 242 seizures seizure NOUN fnp-4496 151 243 . . PUNCT fnp-4496 152 1 she she PRON fnp-4496 152 2 had have VERB fnp-4496 152 3 a a DET fnp-4496 152 4 history history NOUN fnp-4496 152 5 of of ADP fnp-4496 152 6 intractable intractable ADJ fnp-4496 152 7 epilepsy epilepsy NOUN fnp-4496 152 8 after after ADP fnp-4496 152 9 a a DET fnp-4496 152 10 motor motor NOUN fnp-4496 152 11 vehicle vehicle NOUN fnp-4496 152 12 accident accident NOUN fnp-4496 152 13 , , PUNCT fnp-4496 152 14 which which PRON fnp-4496 152 15 was be AUX fnp-4496 152 16 treated treat VERB fnp-4496 152 17 several several ADJ fnp-4496 152 18 decades decade NOUN fnp-4496 152 19 ago ago ADV fnp-4496 152 20 with with ADP fnp-4496 152 21 left left ADJ fnp-4496 152 22 anteromedial anteromedial ADJ fnp-4496 152 23 temporal temporal ADJ fnp-4496 152 24 lobectomy lobectomy NOUN fnp-4496 152 25 and and CCONJ fnp-4496 152 26 hippocampectomy hippocampectomy NOUN fnp-4496 152 27 ; ; PUNCT fnp-4496 152 28 hippocampal hippocampal ADJ fnp-4496 152 29 sclerosis sclerosis NOUN fnp-4496 152 30 was be AUX fnp-4496 152 31 noted note VERB fnp-4496 152 32 at at ADP fnp-4496 152 33 the the DET fnp-4496 152 34 time time NOUN fnp-4496 152 35 . . PUNCT fnp-4496 153 1 at at ADP fnp-4496 153 2 the the DET fnp-4496 153 3 time time NOUN fnp-4496 153 4 of of ADP fnp-4496 153 5 her her PRON fnp-4496 153 6 last last ADJ fnp-4496 153 7 hospital hospital NOUN fnp-4496 153 8 presentation presentation NOUN fnp-4496 153 9 , , PUNCT fnp-4496 153 10 she she PRON fnp-4496 153 11 underwent undergo VERB fnp-4496 153 12 magnetic magnetic ADJ fnp-4496 153 13 resonance resonance NOUN fnp-4496 153 14 imaging imaging NOUN fnp-4496 153 15 , , PUNCT fnp-4496 153 16 which which PRON fnp-4496 153 17 showed show VERB fnp-4496 153 18 a a DET fnp-4496 153 19 leptomeningeal leptomeningeal ADJ fnp-4496 153 20 enhancement enhancement NOUN fnp-4496 153 21 in in ADP fnp-4496 153 22 the the DET fnp-4496 153 23 left left ADJ fnp-4496 153 24 parieto parieto NOUN fnp-4496 153 25 - - PUNCT fnp-4496 153 26 occipital occipital NOUN fnp-4496 153 27 lobe lobe NOUN fnp-4496 153 28 . . PUNCT fnp-4496 154 1 she she PRON fnp-4496 154 2 underwent undergo VERB fnp-4496 154 3 a a DET fnp-4496 154 4 biopsy biopsy NOUN fnp-4496 154 5 for for ADP fnp-4496 154 6 diagnostic diagnostic ADJ fnp-4496 154 7 purposes purpose NOUN fnp-4496 154 8 , , PUNCT fnp-4496 154 9 which which PRON fnp-4496 154 10 showed show VERB fnp-4496 154 11 a a DET fnp-4496 154 12 diffuse diffuse ADJ fnp-4496 154 13 lymphoid lymphoid NOUN fnp-4496 154 14 infiltrate infiltrate NOUN fnp-4496 154 15 predominantly predominantly ADV fnp-4496 154 16 involving involve VERB fnp-4496 154 17 the the DET fnp-4496 154 18 leptomeninges leptomeninge NOUN fnp-4496 154 19 , , PUNCT fnp-4496 154 20 with with ADP fnp-4496 154 21 extension extension NOUN fnp-4496 154 22 into into ADP fnp-4496 154 23 the the DET fnp-4496 154 24 virchow virchow NOUN fnp-4496 154 25 - - PUNCT fnp-4496 154 26 robin robin PROPN fnp-4496 154 27 spaces space NOUN fnp-4496 154 28 and and CCONJ fnp-4496 154 29 with with ADP fnp-4496 154 30 deposits deposit NOUN fnp-4496 154 31 of of ADP fnp-4496 154 32 amorphous amorphous ADJ fnp-4496 154 33 eosinophilic eosinophilic ADJ fnp-4496 154 34 material material NOUN fnp-4496 154 35 . . PUNCT fnp-4496 155 1 the the DET fnp-4496 155 2 lymphoid lymphoid ADJ fnp-4496 155 3 population population NOUN fnp-4496 155 4 comprised comprise VERB fnp-4496 155 5 small small ADJ fnp-4496 155 6 atypical atypical ADJ fnp-4496 155 7 lymphocytes lymphocyte NOUN fnp-4496 155 8 , , PUNCT fnp-4496 155 9 scattered scatter VERB fnp-4496 155 10 plasma plasma NOUN fnp-4496 155 11 cells cell NOUN fnp-4496 155 12 , , PUNCT fnp-4496 155 13 and and CCONJ fnp-4496 155 14 plasmacytoid plasmacytoid NOUN fnp-4496 155 15 lymphocytes lymphocyte VERB fnp-4496 155 16 . . PUNCT fnp-4496 156 1 with with ADP fnp-4496 156 2 immunohistochemistry immunohistochemistry NOUN fnp-4496 156 3 , , PUNCT fnp-4496 156 4 the the DET fnp-4496 156 5 lymphoid lymphoid NOUN fnp-4496 156 6 infiltrate infiltrate NOUN fnp-4496 156 7 was be AUX fnp-4496 156 8 positive positive ADJ fnp-4496 156 9 for for ADP fnp-4496 156 10 cd20 cd20 PROPN fnp-4496 156 11 , , PUNCT fnp-4496 156 12 cd19 cd19 PROPN fnp-4496 156 13 , , PUNCT fnp-4496 156 14 and and CCONJ fnp-4496 156 15 bcl2 bcl2 PROPN fnp-4496 156 16 ; ; PUNCT fnp-4496 156 17 a a DET fnp-4496 156 18 subset subset NOUN fnp-4496 156 19 of of ADP fnp-4496 156 20 cells cell NOUN fnp-4496 156 21 were be AUX fnp-4496 156 22 positive positive ADJ fnp-4496 156 23 for for ADP fnp-4496 156 24 cd138 cd138 PROPN fnp-4496 156 25 and and CCONJ fnp-4496 156 26 mum1 mum1 PROPN fnp-4496 156 27 ; ; PUNCT fnp-4496 156 28 lambda lambda ADJ fnp-4496 156 29 light light NOUN fnp-4496 156 30 chain chain NOUN fnp-4496 156 31 restriction restriction NOUN fnp-4496 156 32 was be AUX fnp-4496 156 33 noted note VERB fnp-4496 156 34 on on ADP fnp-4496 156 35 rna rna PROPN fnp-4496 156 36 in in ADP fnp-4496 156 37 situ situ ADJ fnp-4496 156 38 hybridization hybridization NOUN fnp-4496 156 39 . . PUNCT fnp-4496 157 1 negative negative ADJ fnp-4496 157 2 stains stain NOUN fnp-4496 157 3 included include VERB fnp-4496 157 4 cd3 cd3 PROPN fnp-4496 157 5 , , PUNCT fnp-4496 157 6 cd5 cd5 PROPN fnp-4496 157 7 , , PUNCT fnp-4496 157 8 cd10 cd10 PROPN fnp-4496 157 9 , , PUNCT fnp-4496 157 10 cd21 cd21 PROPN fnp-4496 157 11 , , PUNCT fnp-4496 157 12 cd23 cd23 PROPN fnp-4496 157 13 , , PUNCT fnp-4496 157 14 and and CCONJ fnp-4496 157 15 bcl6 bcl6 PROPN fnp-4496 157 16 . . PUNCT fnp-4496 158 1 the the DET fnp-4496 158 2 ki-67 ki-67 ADJ fnp-4496 158 3 proliferative proliferative ADJ fnp-4496 158 4 index index NOUN fnp-4496 158 5 was be AUX fnp-4496 158 6 estimated estimate VERB fnp-4496 158 7 at at ADP fnp-4496 158 8 5 5 NUM fnp-4496 158 9 % % NOUN fnp-4496 158 10 . . PUNCT fnp-4496 159 1 on on ADP fnp-4496 159 2 congo congo PROPN fnp-4496 159 3 red red ADJ fnp-4496 159 4 stain stain NOUN fnp-4496 159 5 , , PUNCT fnp-4496 159 6 the the DET fnp-4496 159 7 amorphous amorphous ADJ fnp-4496 159 8 material material NOUN fnp-4496 159 9 showed show VERB fnp-4496 159 10 green green ADJ fnp-4496 159 11 birefringence birefringence NOUN fnp-4496 159 12 under under ADP fnp-4496 159 13 polarized polarize VERB fnp-4496 159 14 light light NOUN fnp-4496 159 15 . . PUNCT fnp-4496 160 1 myd88 myd88 PROPN fnp-4496 160 2 mutation mutation NOUN fnp-4496 160 3 was be AUX fnp-4496 160 4 not not PART fnp-4496 160 5 detected detect VERB fnp-4496 160 6 . . PUNCT fnp-4496 161 1 the the DET fnp-4496 161 2 patient patient NOUN fnp-4496 161 3 had have VERB fnp-4496 161 4 no no DET fnp-4496 161 5 evidence evidence NOUN fnp-4496 161 6 of of ADP fnp-4496 161 7 systemic systemic ADJ fnp-4496 161 8 amyloidosis amyloidosis NOUN fnp-4496 161 9 , , PUNCT fnp-4496 161 10 monoclonal monoclonal NOUN fnp-4496 161 11 igm igm NOUN fnp-4496 161 12 gammopathy gammopathy ADJ fnp-4496 161 13 , , PUNCT fnp-4496 161 14 urinary urinary ADJ fnp-4496 161 15 bence bence NOUN fnp-4496 161 16 jones jones PROPN fnp-4496 161 17 protein protein PROPN fnp-4496 161 18 , , PUNCT fnp-4496 161 19 or or CCONJ fnp-4496 161 20 bone bone NOUN fnp-4496 161 21 marrow marrow NOUN fnp-4496 161 22 or or CCONJ fnp-4496 161 23 other other ADJ fnp-4496 161 24 organ organ NOUN fnp-4496 161 25 sites site NOUN fnp-4496 161 26 involvement involvement NOUN fnp-4496 161 27 . . PUNCT fnp-4496 162 1 copyright copyright NOUN fnp-4496 162 2 : : PUNCT fnp-4496 162 3 © © PROPN fnp-4496 162 4 2022 2022 NUM fnp-4496 162 5 the the DET fnp-4496 162 6 author(s author(s NOUN fnp-4496 162 7 ) ) PUNCT fnp-4496 162 8 . . PUNCT fnp-4496 163 1 this this PRON fnp-4496 163 2 is be AUX fnp-4496 163 3 an an DET fnp-4496 163 4 open open ADJ fnp-4496 163 5 access access NOUN fnp-4496 163 6 article article NOUN fnp-4496 163 7 distributed distribute VERB fnp-4496 163 8 under under ADP fnp-4496 163 9 the the DET fnp-4496 163 10 terms term NOUN fnp-4496 163 11 of of ADP fnp-4496 163 12 the the DET fnp-4496 163 13 creative creative ADJ fnp-4496 163 14 commons common NOUN fnp-4496 163 15 attribution attribution NOUN fnp-4496 163 16 4.0 4.0 NUM fnp-4496 163 17 international international ADJ fnp-4496 163 18 license license NOUN fnp-4496 163 19 ( ( PUNCT fnp-4496 163 20 https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/ PROPN fnp-4496 163 21 ) ) PUNCT fnp-4496 163 22 , , PUNCT fnp-4496 163 23 which which PRON fnp-4496 163 24 permits permit VERB fnp-4496 163 25 unrestricted unrestricted ADJ fnp-4496 163 26 use use NOUN fnp-4496 163 27 , , PUNCT fnp-4496 163 28 distribution distribution NOUN fnp-4496 163 29 , , PUNCT fnp-4496 163 30 and and CCONJ fnp-4496 163 31 reproduction reproduction NOUN fnp-4496 163 32 in in ADP fnp-4496 163 33 any any DET fnp-4496 163 34 medium medium NOUN fnp-4496 163 35 , , PUNCT fnp-4496 163 36 provided provide VERB fnp-4496 163 37 the the DET fnp-4496 163 38 original original ADJ fnp-4496 163 39 author author NOUN fnp-4496 163 40 and and CCONJ fnp-4496 163 41 source source NOUN fnp-4496 163 42 are be AUX fnp-4496 163 43 credited credit VERB fnp-4496 163 44 , , PUNCT fnp-4496 163 45 a a DET fnp-4496 163 46 link link NOUN fnp-4496 163 47 to to ADP fnp-4496 163 48 the the DET fnp-4496 163 49 creative creative ADJ fnp-4496 163 50 commons common NOUN fnp-4496 163 51 license license NOUN fnp-4496 163 52 is be AUX fnp-4496 163 53 provided provide VERB fnp-4496 163 54 , , PUNCT fnp-4496 163 55 and and CCONJ fnp-4496 163 56 any any DET fnp-4496 163 57 changes change NOUN fnp-4496 163 58 are be AUX fnp-4496 163 59 indicated indicate VERB fnp-4496 163 60 . . PUNCT fnp-4496 164 1 the the DET fnp-4496 164 2 creative creative ADJ fnp-4496 164 3 commons common NOUN fnp-4496 164 4 public public ADJ fnp-4496 164 5 domain domain NOUN fnp-4496 164 6 dedication dedication NOUN fnp-4496 164 7 waiver waiver NOUN fnp-4496 164 8 ( ( PUNCT fnp-4496 164 9 https://creativecommons.org/publicdomain/zero/1.0/ https://creativecommons.org/publicdomain/zero/1.0/ PROPN fnp-4496 164 10 ) ) PUNCT fnp-4496 164 11 applies apply VERB fnp-4496 164 12 to to ADP fnp-4496 164 13 the the DET fnp-4496 164 14 data datum NOUN fnp-4496 164 15 made make VERB fnp-4496 164 16 available available ADJ fnp-4496 164 17 in in ADP fnp-4496 164 18 this this DET fnp-4496 164 19 article article NOUN fnp-4496 164 20 , , PUNCT fnp-4496 164 21 unless unless SCONJ fnp-4496 164 22 otherwise otherwise ADV fnp-4496 164 23 stated state VERB fnp-4496 164 24 . . PUNCT