id	sid	tid	token	lemma	pos
fnp-4899	1	1	neurodegeneration	neurodegeneration	NOUN
fnp-4899	1	2	:	:	PUNCT
fnp-4899	1	3	2023	2023	NUM
fnp-4899	1	4	update	update	NOUN
fnp-4899	1	5	feel	feel	VERB
fnp-4899	1	6	free	free	ADJ
fnp-4899	1	7	to	to	PART
fnp-4899	1	8	add	add	VERB
fnp-4899	1	9	comments	comment	NOUN
fnp-4899	1	10	by	by	ADP
fnp-4899	1	11	clicking	click	VERB
fnp-4899	1	12	these	these	DET
fnp-4899	1	13	icons	icon	NOUN
fnp-4899	1	14	on	on	ADP
fnp-4899	1	15	the	the	DET
fnp-4899	1	16	sidebar	sidebar	NOUN
fnp-4899	1	17	free	free	ADJ
fnp-4899	1	18	neuropathology	neuropathology	NOUN
fnp-4899	1	19	4:13	4:13	NUM
fnp-4899	1	20	(	(	PUNCT
fnp-4899	1	21	2023	2023	NUM
fnp-4899	1	22	)	)	PUNCT
fnp-4899	1	23	review	review	NOUN
fnp-4899	1	24	neurodegeneration	neurodegeneration	NOUN
fnp-4899	1	25	:	:	PUNCT
fnp-4899	1	26	2023	2023	NUM
fnp-4899	1	27	update	update	NOUN
fnp-4899	1	28	john	john	PROPN
fnp-4899	1	29	f.	f.	PROPN
fnp-4899	1	30	crary	crary	PROPN
fnp-4899	1	31	department	department	PROPN
fnp-4899	1	32	of	of	ADP
fnp-4899	1	33	pathology	pathology	PROPN
fnp-4899	1	34	,	,	PUNCT
fnp-4899	1	35	nash	nash	PROPN
fnp-4899	1	36	family	family	PROPN
fnp-4899	1	37	department	department	PROPN
fnp-4899	1	38	of	of	ADP
fnp-4899	1	39	neuroscience	neuroscience	NOUN
fnp-4899	1	40	,	,	PUNCT
fnp-4899	1	41	department	department	NOUN
fnp-4899	1	42	of	of	ADP
fnp-4899	1	43	artificial	artificial	ADJ
fnp-4899	1	44	intelligence	intelligence	PROPN
fnp-4899	1	45	&	&	CCONJ
fnp-4899	1	46	human	human	PROPN
fnp-4899	1	47	health	health	PROPN
fnp-4899	1	48	,	,	PUNCT
fnp-4899	1	49	neuropathology	neuropathology	NOUN
fnp-4899	1	50	brain	brain	PROPN
fnp-4899	1	51	bank	bank	PROPN
fnp-4899	1	52	&	&	CCONJ
fnp-4899	1	53	research	research	PROPN
fnp-4899	1	54	core	core	NOUN
fnp-4899	1	55	,	,	PUNCT
fnp-4899	1	56	ronald	ronald	PROPN
fnp-4899	1	57	m.	m.	PROPN
fnp-4899	1	58	loeb	loeb	PROPN
fnp-4899	1	59	center	center	PROPN
fnp-4899	1	60	for	for	ADP
fnp-4899	1	61	alzheimer	alzheimer	PROPN
fnp-4899	1	62	's	's	PART
fnp-4899	1	63	disease	disease	NOUN
fnp-4899	1	64	,	,	PUNCT
fnp-4899	1	65	friedman	friedman	PROPN
fnp-4899	1	66	brain	brain	PROPN
fnp-4899	1	67	institute	institute	PROPN
fnp-4899	1	68	,	,	PUNCT
fnp-4899	1	69	icahn	icahn	PROPN
fnp-4899	1	70	school	school	PROPN
fnp-4899	1	71	of	of	ADP
fnp-4899	1	72	medicine	medicine	NOUN
fnp-4899	1	73	at	at	ADP
fnp-4899	1	74	mount	mount	PROPN
fnp-4899	1	75	sinai	sinai	PROPN
fnp-4899	1	76	,	,	PUNCT
fnp-4899	1	77	new	new	PROPN
fnp-4899	1	78	york	york	PROPN
fnp-4899	1	79	,	,	PUNCT
fnp-4899	1	80	ny	ny	PROPN
fnp-4899	1	81	,	,	PUNCT
fnp-4899	1	82	usa	usa	PROPN
fnp-4899	1	83	corresponding	corresponding	PROPN
fnp-4899	1	84	author	author	NOUN
fnp-4899	1	85	:	:	PUNCT
fnp-4899	2	1	john	john	PROPN
fnp-4899	2	2	f.	f.	PROPN
fnp-4899	2	3	crary	crary	PROPN
fnp-4899	2	4	·	·	PUNCT
fnp-4899	2	5	icahn	icahn	PROPN
fnp-4899	2	6	school	school	NOUN
fnp-4899	2	7	of	of	ADP
fnp-4899	2	8	medicine	medicine	NOUN
fnp-4899	2	9	at	at	ADP
fnp-4899	2	10	mount	mount	PROPN
fnp-4899	2	11	sinai	sinai	PROPN
fnp-4899	2	12	·	·	PUNCT
fnp-4899	2	13	1	1	NUM
fnp-4899	2	14	gustave	gustave	X
fnp-4899	2	15	l.	l.	PROPN
fnp-4899	2	16	levy	levy	PROPN
fnp-4899	2	17	place	place	PROPN
fnp-4899	2	18	box	box	PROPN
fnp-4899	2	19	1194	1194	NUM
fnp-4899	2	20	·	·	PUNCT
fnp-4899	2	21	new	new	PROPN
fnp-4899	2	22	york	york	PROPN
fnp-4899	2	23	,	,	PUNCT
fnp-4899	2	24	ny	ny	PROPN
fnp-4899	2	25	10029	10029	NUM
fnp-4899	2	26	·	·	PUNCT
fnp-4899	2	27	usa	usa	PROPN
fnp-4899	2	28	john.crary@mountsinai.org	john.crary@mountsinai.org	PROPN
fnp-4899	2	29	submitted	submit	VERB
fnp-4899	2	30	:	:	PUNCT
fnp-4899	2	31	06	06	NUM
fnp-4899	2	32	june	june	PROPN
fnp-4899	2	33	2023	2023	NUM
fnp-4899	2	34	accepted	accept	VERB
fnp-4899	2	35	:	:	PUNCT
fnp-4899	2	36	10	10	NUM
fnp-4899	2	37	august	august	PROPN
fnp-4899	2	38	2023	2023	NUM
fnp-4899	2	39	copyedited	copyedit	VERB
fnp-4899	2	40	by	by	ADP
fnp-4899	2	41	:	:	PUNCT
fnp-4899	2	42	aivi	aivi	PROPN
fnp-4899	2	43	nguyen	nguyen	PROPN
fnp-4899	2	44	published	publish	VERB
fnp-4899	2	45	:	:	PUNCT
fnp-4899	2	46	04	04	NUM
fnp-4899	2	47	september	september	PROPN
fnp-4899	2	48	2023	2023	NUM
fnp-4899	3	1	https://doi.org/10.17879/freeneuropathology-2023-4899	https://doi.org/10.17879/freeneuropathology-2023-4899	NOUN
fnp-4899	3	2	keywords	keyword	NOUN
fnp-4899	3	3	:	:	PUNCT
fnp-4899	3	4	neurodegeneration	neurodegeneration	NOUN
fnp-4899	3	5	,	,	PUNCT
fnp-4899	3	6	neuropathology	neuropathology	NOUN
fnp-4899	3	7	,	,	PUNCT
fnp-4899	3	8	aging	aging	NOUN
fnp-4899	3	9	,	,	PUNCT
fnp-4899	3	10	alzheimer	alzheimer	PROPN
fnp-4899	3	11	disease	disease	NOUN
fnp-4899	3	12	,	,	PUNCT
fnp-4899	3	13	tauopathy	tauopathy	NOUN
fnp-4899	3	14	,	,	PUNCT
fnp-4899	3	15	α	α	NOUN
fnp-4899	3	16	-	-	PUNCT
fnp-4899	3	17	synucleinopathy	synucleinopathy	ADJ
fnp-4899	3	18	,	,	PUNCT
fnp-4899	3	19	tdp-43	tdp-43	NOUN
fnp-4899	3	20	proteinopathy	proteinopathy	ADJ
fnp-4899	3	21	,	,	PUNCT
fnp-4899	3	22	traumatic	traumatic	ADJ
fnp-4899	3	23	brain	brain	NOUN
fnp-4899	3	24	injury	injury	NOUN
fnp-4899	3	25	abstract	abstract	ADP
fnp-4899	3	26	this	this	DET
fnp-4899	3	27	paper	paper	NOUN
fnp-4899	3	28	reviews	review	NOUN
fnp-4899	3	29	ten	ten	NUM
fnp-4899	3	30	highly	highly	ADV
fnp-4899	3	31	impactful	impactful	ADJ
fnp-4899	3	32	studies	study	NOUN
fnp-4899	3	33	published	publish	VERB
fnp-4899	3	34	in	in	ADP
fnp-4899	3	35	the	the	DET
fnp-4899	3	36	previous	previous	ADJ
fnp-4899	3	37	year	year	NOUN
fnp-4899	3	38	selected	select	VERB
fnp-4899	3	39	by	by	ADP
fnp-4899	3	40	the	the	DET
fnp-4899	3	41	author	author	NOUN
fnp-4899	3	42	from	from	ADP
fnp-4899	3	43	the	the	DET
fnp-4899	3	44	neurodegenerative	neurodegenerative	ADJ
fnp-4899	3	45	neuropathology	neuropathology	NOUN
fnp-4899	3	46	literature	literature	NOUN
fnp-4899	3	47	.	.	PUNCT
fnp-4899	4	1	as	as	ADP
fnp-4899	4	2	in	in	ADP
fnp-4899	4	3	previous	previous	ADJ
fnp-4899	4	4	years	year	NOUN
fnp-4899	4	5	,	,	PUNCT
fnp-4899	4	6	the	the	DET
fnp-4899	4	7	focus	focus	NOUN
fnp-4899	4	8	is	be	AUX
fnp-4899	4	9	to	to	PART
fnp-4899	4	10	highlight	highlight	VERB
fnp-4899	4	11	human	human	ADJ
fnp-4899	4	12	tissue	tissue	NOUN
fnp-4899	4	13	-	-	PUNCT
fnp-4899	4	14	based	base	VERB
fnp-4899	4	15	experimentation	experimentation	NOUN
fnp-4899	4	16	most	most	ADV
fnp-4899	4	17	relevant	relevant	ADJ
fnp-4899	4	18	to	to	ADP
fnp-4899	4	19	neuropathologists	neuropathologist	NOUN
fnp-4899	4	20	.	.	PUNCT
fnp-4899	5	1	a	a	DET
fnp-4899	5	2	concerted	concerted	ADJ
fnp-4899	5	3	effort	effort	NOUN
fnp-4899	5	4	was	be	AUX
fnp-4899	5	5	made	make	VERB
fnp-4899	5	6	to	to	PART
fnp-4899	5	7	balance	balance	VERB
fnp-4899	5	8	the	the	DET
fnp-4899	5	9	selected	select	VERB
fnp-4899	5	10	studies	study	NOUN
fnp-4899	5	11	across	across	ADP
fnp-4899	5	12	disease	disease	NOUN
fnp-4899	5	13	categories	category	NOUN
fnp-4899	5	14	,	,	PUNCT
fnp-4899	5	15	approaches	approach	NOUN
fnp-4899	5	16	,	,	PUNCT
fnp-4899	5	17	and	and	CCONJ
fnp-4899	5	18	methodologies	methodology	NOUN
fnp-4899	5	19	to	to	PART
fnp-4899	5	20	capture	capture	VERB
fnp-4899	5	21	the	the	DET
fnp-4899	5	22	breadth	breadth	NOUN
fnp-4899	5	23	of	of	ADP
fnp-4899	5	24	the	the	DET
fnp-4899	5	25	research	research	NOUN
fnp-4899	5	26	landscape	landscape	NOUN
fnp-4899	5	27	.	.	PUNCT
fnp-4899	6	1	studies	study	NOUN
fnp-4899	6	2	include	include	VERB
fnp-4899	6	3	an	an	DET
fnp-4899	6	4	integrated	integrated	ADJ
fnp-4899	6	5	proteomic	proteomic	ADJ
fnp-4899	6	6	and	and	CCONJ
fnp-4899	6	7	transcriptomic	transcriptomic	ADJ
fnp-4899	6	8	study	study	NOUN
fnp-4899	6	9	of	of	ADP
fnp-4899	6	10	alzheimer	alzheimer	PROPN
fnp-4899	6	11	disease	disease	PROPN
fnp-4899	6	12	(	(	PUNCT
fnp-4899	6	13	ad	ad	NOUN
fnp-4899	6	14	)	)	PUNCT
fnp-4899	6	15	and	and	CCONJ
fnp-4899	6	16	new	new	ADJ
fnp-4899	6	17	consensus	consensus	NOUN
fnp-4899	6	18	diagnostic	diagnostic	ADJ
fnp-4899	6	19	neuropathological	neuropathological	ADJ
fnp-4899	6	20	criteria	criterion	NOUN
fnp-4899	6	21	for	for	ADP
fnp-4899	6	22	progressive	progressive	ADJ
fnp-4899	6	23	supranuclear	supranuclear	ADJ
fnp-4899	6	24	palsy	palsy	ADJ
fnp-4899	6	25	.	.	PUNCT
fnp-4899	7	1	a	a	DET
fnp-4899	7	2	number	number	NOUN
fnp-4899	7	3	of	of	ADP
fnp-4899	7	4	studies	study	NOUN
fnp-4899	7	5	looking	look	VERB
fnp-4899	7	6	at	at	ADP
fnp-4899	7	7	tar	tar	NOUN
fnp-4899	7	8	dna	dna	ADV
fnp-4899	7	9	-	-	PUNCT
fnp-4899	7	10	binding	bind	VERB
fnp-4899	7	11	protein	protein	NOUN
fnp-4899	7	12	43	43	NUM
fnp-4899	7	13	(	(	PUNCT
fnp-4899	7	14	tdp-43	tdp-43	NOUN
fnp-4899	7	15	)	)	PUNCT
fnp-4899	7	16	are	be	AUX
fnp-4899	7	17	highlighted	highlight	VERB
fnp-4899	7	18	.	.	PUNCT
fnp-4899	8	1	one	one	NUM
fnp-4899	8	2	examined	examine	VERB
fnp-4899	8	3	interaction	interaction	NOUN
fnp-4899	8	4	between	between	ADP
fnp-4899	8	5	ad	ad	NOUN
fnp-4899	8	6	and	and	CCONJ
fnp-4899	8	7	limbic	limbic	ADJ
fnp-4899	8	8	age	age	NOUN
fnp-4899	8	9	-	-	PUNCT
fnp-4899	8	10	related	relate	VERB
fnp-4899	8	11	tdp-43	tdp-43	NOUN
fnp-4899	8	12	encephalopathy	encephalopathy	ADJ
fnp-4899	8	13	(	(	PUNCT
fnp-4899	8	14	late	late	ADJ
fnp-4899	8	15	)	)	PUNCT
fnp-4899	8	16	and	and	CCONJ
fnp-4899	8	17	yet	yet	ADV
fnp-4899	8	18	another	another	PRON
fnp-4899	8	19	demonstrated	demonstrate	VERB
fnp-4899	8	20	how	how	SCONJ
fnp-4899	8	21	tdp-43	tdp-43	NOUN
fnp-4899	8	22	represses	repress	VERB
fnp-4899	8	23	cryptic	cryptic	ADJ
fnp-4899	8	24	exon	exon	NOUN
fnp-4899	8	25	inclusion	inclusion	NOUN
fnp-4899	8	26	in	in	ADP
fnp-4899	8	27	unc13a	unc13a	NOUN
fnp-4899	8	28	,	,	PUNCT
fnp-4899	8	29	suggesting	suggest	VERB
fnp-4899	8	30	a	a	DET
fnp-4899	8	31	novel	novel	ADJ
fnp-4899	8	32	pathogenic	pathogenic	ADJ
fnp-4899	8	33	mechanism	mechanism	NOUN
fnp-4899	8	34	.	.	PUNCT
fnp-4899	9	1	most	most	ADV
fnp-4899	9	2	surprisingly	surprisingly	ADV
fnp-4899	9	3	,	,	PUNCT
fnp-4899	9	4	three	three	NUM
fnp-4899	9	5	cryogenic	cryogenic	NOUN
fnp-4899	9	6	electron	electron	NOUN
fnp-4899	9	7	microscopy	microscopy	NOUN
fnp-4899	9	8	(	(	PUNCT
fnp-4899	9	9	cryo	cryo	NOUN
fnp-4899	9	10	-	-	PUNCT
fnp-4899	9	11	em	em	NOUN
fnp-4899	9	12	)	)	PUNCT
fnp-4899	9	13	studies	study	NOUN
fnp-4899	9	14	showed	show	VERB
fnp-4899	9	15	that	that	SCONJ
fnp-4899	9	16	tmem106b	tmem106b	ADJ
fnp-4899	9	17	filaments	filament	NOUN
fnp-4899	9	18	form	form	VERB
fnp-4899	9	19	the	the	DET
fnp-4899	9	20	core	core	NOUN
fnp-4899	9	21	of	of	ADP
fnp-4899	9	22	tdp-43	tdp-43	NOUN
fnp-4899	9	23	-	-	PUNCT
fnp-4899	9	24	positive	positive	ADJ
fnp-4899	9	25	inclusions	inclusion	NOUN
fnp-4899	9	26	.	.	PUNCT
fnp-4899	10	1	cryo	cryo	NOUN
fnp-4899	10	2	-	-	PUNCT
fnp-4899	10	3	em	em	PRON
fnp-4899	10	4	revealed	reveal	VERB
fnp-4899	10	5	a	a	DET
fnp-4899	10	6	prion	prion	NOUN
fnp-4899	10	7	protein	protein	NOUN
fnp-4899	10	8	amyloid	amyloid	NOUN
fnp-4899	10	9	structure	structure	NOUN
fnp-4899	10	10	from	from	ADP
fnp-4899	10	11	aggregates	aggregate	NOUN
fnp-4899	10	12	in	in	ADP
fnp-4899	10	13	gerstmann	gerstmann	NOUN
fnp-4899	10	14	-	-	PUNCT
fnp-4899	10	15	sträussler	sträussler	NOUN
fnp-4899	10	16	-	-	PUNCT
fnp-4899	10	17	scheinker	scheinker	NOUN
fnp-4899	10	18	disease	disease	NOUN
fnp-4899	10	19	.	.	PUNCT
fnp-4899	11	1	there	there	PRON
fnp-4899	11	2	was	be	VERB
fnp-4899	11	3	an	an	DET
fnp-4899	11	4	elegant	elegant	ADJ
fnp-4899	11	5	functional	functional	ADJ
fnp-4899	11	6	genomic	genomic	NOUN
fnp-4899	11	7	study	study	NOUN
fnp-4899	11	8	cataloging	catalog	VERB
fnp-4899	11	9	microglial	microglial	ADJ
fnp-4899	11	10	gene	gene	NOUN
fnp-4899	11	11	expression	expression	NOUN
fnp-4899	11	12	in	in	ADP
fnp-4899	11	13	the	the	DET
fnp-4899	11	14	human	human	ADJ
fnp-4899	11	15	brain	brain	NOUN
fnp-4899	11	16	.	.	PUNCT
fnp-4899	12	1	a	a	DET
fnp-4899	12	2	study	study	NOUN
fnp-4899	12	3	shed	shed	VERB
fnp-4899	12	4	light	light	NOUN
fnp-4899	12	5	on	on	ADP
fnp-4899	12	6	how	how	SCONJ
fnp-4899	12	7	apoe	apoe	ADJ
fnp-4899	12	8	influences	influence	VERB
fnp-4899	12	9	chronic	chronic	ADJ
fnp-4899	12	10	traumatic	traumatic	ADJ
fnp-4899	12	11	encephalopathy	encephalopathy	NOUN
fnp-4899	12	12	.	.	PUNCT
fnp-4899	13	1	a	a	DET
fnp-4899	13	2	pathoanatomical	pathoanatomical	ADJ
fnp-4899	13	3	study	study	NOUN
fnp-4899	13	4	tested	test	VERB
fnp-4899	13	5	the	the	DET
fnp-4899	13	6	dual	dual	ADJ
fnp-4899	13	7	hit	hit	VERB
fnp-4899	13	8	hypothesis	hypothesis	NOUN
fnp-4899	13	9	of	of	ADP
fnp-4899	13	10	lewy	lewy	ADJ
fnp-4899	13	11	body	body	NOUN
fnp-4899	13	12	progression	progression	NOUN
fnp-4899	13	13	throughout	throughout	ADP
fnp-4899	13	14	the	the	DET
fnp-4899	13	15	nervous	nervous	ADJ
fnp-4899	13	16	system	system	NOUN
fnp-4899	13	17	.	.	PUNCT
fnp-4899	14	1	and	and	CCONJ
fnp-4899	14	2	finally	finally	ADV
fnp-4899	14	3	,	,	PUNCT
fnp-4899	14	4	deep	deep	ADJ
fnp-4899	14	5	learning	learning	NOUN
fnp-4899	14	6	continues	continue	VERB
fnp-4899	14	7	to	to	PART
fnp-4899	14	8	show	show	VERB
fnp-4899	14	9	its	its	PRON
fnp-4899	14	10	promise	promise	NOUN
fnp-4899	14	11	with	with	ADP
fnp-4899	14	12	application	application	NOUN
fnp-4899	14	13	of	of	ADP
fnp-4899	14	14	a	a	DET
fnp-4899	14	15	weakly	weakly	ADV
fnp-4899	14	16	supervised	supervised	ADJ
fnp-4899	14	17	multiple	multiple	ADJ
fnp-4899	14	18	instance	instance	NOUN
fnp-4899	14	19	learning	learn	VERB
fnp-4899	14	20	paradigm	paradigm	NOUN
fnp-4899	14	21	to	to	PART
fnp-4899	14	22	assess	assess	VERB
fnp-4899	14	23	aging	age	VERB
fnp-4899	14	24	post	post	ADJ
fnp-4899	14	25	-	-	ADJ
fnp-4899	14	26	mortem	mortem	ADJ
fnp-4899	14	27	brains	brain	NOUN
fnp-4899	14	28	.	.	PUNCT
fnp-4899	15	1	1	1	X
fnp-4899	15	2	.	.	X
fnp-4899	15	3	an	an	DET
fnp-4899	15	4	integrated	integrate	VERB
fnp-4899	15	5	proteomic	proteomic	NOUN
fnp-4899	15	6	and	and	CCONJ
fnp-4899	15	7	transcriptomic	transcriptomic	ADJ
fnp-4899	15	8	analysis	analysis	NOUN
fnp-4899	15	9	of	of	ADP
fnp-4899	15	10	alzheimer	alzheimer	PROPN
fnp-4899	15	11	disease	disease	NOUN
fnp-4899	15	12	reveals	reveal	VERB
fnp-4899	15	13	unique	unique	ADJ
fnp-4899	15	14	pathways	pathway	NOUN
fnp-4899	15	15	beyond	beyond	ADP
fnp-4899	15	16	mrna	mrna	PROPN
fnp-4899	15	17	powerful	powerful	ADJ
fnp-4899	15	18	transcriptomic	transcriptomic	ADJ
fnp-4899	15	19	approaches	approach	NOUN
fnp-4899	15	20	are	be	AUX
fnp-4899	15	21	increasingly	increasingly	ADV
fnp-4899	15	22	being	be	AUX
fnp-4899	15	23	applied	apply	VERB
fnp-4899	15	24	to	to	ADP
fnp-4899	15	25	post	post	ADJ
fnp-4899	15	26	-	-	ADJ
fnp-4899	15	27	mortem	mortem	ADJ
fnp-4899	15	28	alzheimer	alzheimer	NOUN
fnp-4899	15	29	disease	disease	NOUN
fnp-4899	15	30	(	(	PUNCT
fnp-4899	15	31	ad	ad	NOUN
fnp-4899	15	32	)	)	PUNCT
fnp-4899	15	33	tissues	tissue	NOUN
fnp-4899	15	34	and	and	CCONJ
fnp-4899	15	35	other	other	ADJ
fnp-4899	15	36	diseases	disease	NOUN
fnp-4899	15	37	.	.	PUNCT
fnp-4899	16	1	historically	historically	ADV
fnp-4899	16	2	,	,	PUNCT
fnp-4899	16	3	methods	method	NOUN
fnp-4899	16	4	included	include	VERB
fnp-4899	16	5	hybridization	hybridization	NOUN
fnp-4899	16	6	-	-	PUNCT
fnp-4899	16	7	based	base	VERB
fnp-4899	16	8	microarrays	microarray	NOUN
fnp-4899	16	9	and	and	CCONJ
fnp-4899	16	10	bulk	bulk	NOUN
fnp-4899	16	11	rna	rna	NOUN
fnp-4899	16	12	-	-	PUNCT
fnp-4899	16	13	sequencing	sequence	VERB
fnp-4899	16	14	,	,	PUNCT
fnp-4899	16	15	but	but	CCONJ
fnp-4899	16	16	increasingly	increasingly	ADV
fnp-4899	16	17	single	single	ADJ
fnp-4899	16	18	cell	cell	NOUN
fnp-4899	16	19	rna	rna	NOUN
fnp-4899	16	20	profiling	profiling	NOUN
fnp-4899	16	21	and	and	CCONJ
fnp-4899	16	22	spatial	spatial	ADJ
fnp-4899	16	23	transcriptomics	transcriptomic	NOUN
fnp-4899	16	24	are	be	AUX
fnp-4899	16	25	becoming	become	VERB
fnp-4899	16	26	routine	routine	ADJ
fnp-4899	16	27	.	.	PUNCT
fnp-4899	17	1	proteins	protein	NOUN
fnp-4899	17	2	,	,	PUNCT
fnp-4899	17	3	owing	owe	VERB
fnp-4899	17	4	to	to	ADP
fnp-4899	17	5	their	their	PRON
fnp-4899	17	6	increased	increase	VERB
fnp-4899	17	7	complexity	complexity	NOUN
fnp-4899	17	8	,	,	PUNCT
fnp-4899	17	9	are	be	AUX
fnp-4899	17	10	more	more	ADV
fnp-4899	17	11	challenging	challenging	ADJ
fnp-4899	17	12	to	to	PART
fnp-4899	17	13	assess	assess	VERB
fnp-4899	17	14	,	,	PUNCT
fnp-4899	17	15	but	but	CCONJ
fnp-4899	17	16	are	be	AUX
fnp-4899	17	17	ostensibly	ostensibly	ADV
fnp-4899	17	18	more	more	ADJ
fnp-4899	17	19	proximate	proximate	NOUN
fnp-4899	17	20	to	to	ADP
fnp-4899	17	21	the	the	DET
fnp-4899	17	22	relevant	relevant	ADJ
fnp-4899	17	23	alterations	alteration	NOUN
fnp-4899	17	24	that	that	PRON
fnp-4899	17	25	drive	drive	VERB
fnp-4899	17	26	neurodegeneration	neurodegeneration	NOUN
fnp-4899	17	27	.	.	PUNCT
fnp-4899	18	1	a	a	DET
fnp-4899	18	2	study	study	NOUN
fnp-4899	18	3	by	by	ADP
fnp-4899	18	4	johnson	johnson	PROPN
fnp-4899	18	5	et	et	PROPN
fnp-4899	18	6	al	al	PROPN
fnp-4899	18	7	.	.	PROPN
fnp-4899	18	8	entitled	entitle	VERB
fnp-4899	18	9	“	"	PUNCT
fnp-4899	18	10	large	large	ADJ
fnp-4899	18	11	-	-	PUNCT
fnp-4899	18	12	scale	scale	NOUN
fnp-4899	18	13	deep	deep	ADJ
fnp-4899	18	14	multi	multi	ADJ
fnp-4899	18	15	-	-	ADJ
fnp-4899	18	16	layer	layer	ADJ
fnp-4899	18	17	analysis	analysis	NOUN
fnp-4899	18	18	of	of	ADP
fnp-4899	18	19	alzheimer	alzheimer	PROPN
fnp-4899	18	20	's	's	PART
fnp-4899	18	21	disease	disease	NOUN
fnp-4899	18	22	brain	brain	NOUN
fnp-4899	18	23	reveals	reveal	VERB
fnp-4899	18	24	strong	strong	ADJ
fnp-4899	18	25	proteomic	proteomic	ADJ
fnp-4899	18	26	disease	disease	NOUN
fnp-4899	18	27	-	-	PUNCT
fnp-4899	18	28	related	relate	VERB
fnp-4899	18	29	changes	change	NOUN
fnp-4899	18	30	not	not	PART
fnp-4899	18	31	observed	observe	VERB
fnp-4899	18	32	at	at	ADP
fnp-4899	18	33	the	the	DET
fnp-4899	18	34	rna	rna	NOUN
fnp-4899	18	35	level	level	NOUN
fnp-4899	18	36	”	"	PUNCT
fnp-4899	18	37	analyzed	analyze	VERB
fnp-4899	18	38	proteomes	proteome	NOUN
fnp-4899	18	39	of	of	ADP
fnp-4899	18	40	more	more	ADJ
fnp-4899	18	41	than	than	ADP
fnp-4899	18	42	1,000	1,000	NUM
fnp-4899	18	43	brain	brain	NOUN
fnp-4899	18	44	tissues	tissue	NOUN
fnp-4899	18	45	with	with	ADP
fnp-4899	18	46	a	a	DET
fnp-4899	18	47	goal	goal	NOUN
fnp-4899	18	48	of	of	ADP
fnp-4899	18	49	trying	try	VERB
fnp-4899	18	50	to	to	PART
fnp-4899	18	51	better	well	ADV
fnp-4899	18	52	understand	understand	VERB
fnp-4899	18	53	the	the	DET
fnp-4899	18	54	biological	biological	ADJ
fnp-4899	18	55	processes	process	NOUN
fnp-4899	18	56	disrupted	disrupt	VERB
fnp-4899	18	57	in	in	ADP
fnp-4899	18	58	ad	ad	NOUN
fnp-4899	18	59	(	(	PUNCT
fnp-4899	18	60	johnson	johnson	PROPN
fnp-4899	18	61	et	et	PROPN
fnp-4899	18	62	al	al	PROPN
fnp-4899	18	63	.	.	PROPN
fnp-4899	18	64	,	,	PUNCT
fnp-4899	18	65	2022	2022	NUM
fnp-4899	18	66	)	)	PUNCT
fnp-4899	18	67	.	.	PUNCT
fnp-4899	19	1	the	the	DET
fnp-4899	19	2	investigators	investigator	NOUN
fnp-4899	19	3	deployed	deploy	VERB
fnp-4899	19	4	tandem	tandem	PROPN
fnp-4899	19	5	mass	mass	PROPN
fnp-4899	19	6	tag	tag	PROPN
fnp-4899	19	7	mass	mass	NOUN
fnp-4899	19	8	spectrometry	spectrometry	NOUN
fnp-4899	19	9	(	(	PUNCT
fnp-4899	19	10	tmt	tmt	PROPN
fnp-4899	19	11	-	-	PUNCT
fnp-4899	19	12	ms	ms	PROPN
fnp-4899	19	13	)	)	PUNCT
fnp-4899	19	14	,	,	PUNCT
fnp-4899	19	15	an	an	DET
fnp-4899	19	16	approach	approach	NOUN
fnp-4899	19	17	used	use	VERB
fnp-4899	19	18	to	to	PART
fnp-4899	19	19	quantitatively	quantitatively	ADV
fnp-4899	19	20	analyze	analyze	VERB
fnp-4899	19	21	and	and	CCONJ
fnp-4899	19	22	compare	compare	VERB
fnp-4899	19	23	protein	protein	NOUN
fnp-4899	19	24	expression	expression	NOUN
fnp-4899	19	25	levels	level	NOUN
fnp-4899	19	26	that	that	PRON
fnp-4899	19	27	uses	use	VERB
fnp-4899	19	28	isobaric	isobaric	ADJ
fnp-4899	19	29	tagging	tagging	NOUN
fnp-4899	19	30	to	to	PART
fnp-4899	19	31	enable	enable	VERB
fnp-4899	19	32	multiplexed	multiplexed	ADJ
fnp-4899	19	33	quantification	quantification	NOUN
fnp-4899	19	34	of	of	ADP
fnp-4899	19	35	peptides	peptide	NOUN
fnp-4899	19	36	and	and	CCONJ
fnp-4899	19	37	proteins	protein	NOUN
fnp-4899	19	38	.	.	PUNCT
fnp-4899	20	1	tmt	tmt	PROPN
fnp-4899	20	2	-	-	PUNCT
fnp-4899	20	3	ms	ms	PROPN
fnp-4899	20	4	offers	offer	VERB
fnp-4899	20	5	several	several	ADJ
fnp-4899	20	6	advantages	advantage	NOUN
fnp-4899	20	7	,	,	PUNCT
fnp-4899	20	8	including	include	VERB
fnp-4899	20	9	high	high	ADJ
fnp-4899	20	10	multiplexing	multiplexing	NOUN
fnp-4899	20	11	capacity	capacity	NOUN
fnp-4899	20	12	,	,	PUNCT
fnp-4899	20	13	accurate	accurate	ADJ
fnp-4899	20	14	and	and	CCONJ
fnp-4899	20	15	reproducible	reproducible	ADJ
fnp-4899	20	16	quantification	quantification	NOUN
fnp-4899	20	17	,	,	PUNCT
fnp-4899	20	18	and	and	CCONJ
fnp-4899	20	19	the	the	DET
fnp-4899	20	20	ability	ability	NOUN
fnp-4899	20	21	to	to	PART
fnp-4899	20	22	analyze	analyze	VERB
fnp-4899	20	23	complex	complex	ADJ
fnp-4899	20	24	proteomes	proteome	NOUN
fnp-4899	20	25	.	.	PUNCT
fnp-4899	21	1	using	use	VERB
fnp-4899	21	2	this	this	DET
fnp-4899	21	3	methodology	methodology	NOUN
fnp-4899	21	4	,	,	PUNCT
fnp-4899	21	5	the	the	DET
fnp-4899	21	6	research	research	NOUN
fnp-4899	21	7	team	team	NOUN
fnp-4899	21	8	identified	identify	VERB
fnp-4899	21	9	new	new	ADJ
fnp-4899	21	10	ad	ad	NOUN
fnp-4899	21	11	-	-	PUNCT
fnp-4899	21	12	related	relate	VERB
fnp-4899	21	13	protein	protein	NOUN
fnp-4899	21	14	co	co	NOUN
fnp-4899	21	15	-	-	NOUN
fnp-4899	21	16	expression	expression	ADJ
fnp-4899	21	17	modules	module	NOUN
fnp-4899	21	18	that	that	PRON
fnp-4899	21	19	were	be	AUX
fnp-4899	21	20	highly	highly	ADV
fnp-4899	21	21	preserved	preserve	VERB
fnp-4899	21	22	across	across	ADP
fnp-4899	21	23	cohorts	cohort	NOUN
fnp-4899	21	24	and	and	CCONJ
fnp-4899	21	25	brain	brain	NOUN
fnp-4899	21	26	regions	region	NOUN
fnp-4899	21	27	.	.	PUNCT
fnp-4899	22	1	remarkably	remarkably	ADV
fnp-4899	22	2	,	,	PUNCT
fnp-4899	22	3	nearly	nearly	ADV
fnp-4899	22	4	half	half	NOUN
fnp-4899	22	5	of	of	ADP
fnp-4899	22	6	the	the	DET
fnp-4899	22	7	protein	protein	NOUN
fnp-4899	22	8	co	co	NOUN
fnp-4899	22	9	-	-	NOUN
fnp-4899	22	10	expression	expression	ADJ
fnp-4899	22	11	modules	module	NOUN
fnp-4899	22	12	were	be	AUX
fnp-4899	22	13	not	not	PART
fnp-4899	22	14	observed	observe	VERB
fnp-4899	22	15	in	in	ADP
fnp-4899	22	16	mrna	mrna	PROPN
fnp-4899	22	17	networks	network	NOUN
fnp-4899	22	18	.	.	PUNCT
fnp-4899	23	1	two	two	NUM
fnp-4899	23	2	notable	notable	ADJ
fnp-4899	23	3	ad	ad	NOUN
fnp-4899	23	4	-	-	PUNCT
fnp-4899	23	5	associated	associate	VERB
fnp-4899	23	6	modules	module	NOUN
fnp-4899	23	7	that	that	PRON
fnp-4899	23	8	were	be	AUX
fnp-4899	23	9	unique	unique	ADJ
fnp-4899	23	10	to	to	ADP
fnp-4899	23	11	the	the	DET
fnp-4899	23	12	proteomic	proteomic	ADJ
fnp-4899	23	13	network	network	NOUN
fnp-4899	23	14	were	be	AUX
fnp-4899	23	15	related	relate	VERB
fnp-4899	23	16	to	to	ADP
fnp-4899	23	17	mitogen	mitogen	NOUN
fnp-4899	23	18	-	-	PUNCT
fnp-4899	23	19	activated	activate	VERB
fnp-4899	23	20	protein	protein	NOUN
fnp-4899	23	21	kinase	kinase	NOUN
fnp-4899	23	22	(	(	PUNCT
fnp-4899	23	23	mapk	mapk	NOUN
fnp-4899	23	24	)	)	PUNCT
fnp-4899	23	25	signaling	signal	VERB
fnp-4899	23	26	and	and	CCONJ
fnp-4899	23	27	the	the	DET
fnp-4899	23	28	matrisome	matrisome	ADJ
fnp-4899	23	29	(	(	PUNCT
fnp-4899	23	30	figure	figure	NOUN
fnp-4899	23	31	1	1	NUM
fnp-4899	23	32	)	)	PUNCT
fnp-4899	23	33	.	.	PUNCT
fnp-4899	24	1	the	the	DET
fnp-4899	24	2	matrisome	matrisome	PROPN
fnp-4899	24	3	refers	refer	VERB
fnp-4899	24	4	to	to	ADP
fnp-4899	24	5	the	the	DET
fnp-4899	24	6	collection	collection	NOUN
fnp-4899	24	7	of	of	ADP
fnp-4899	24	8	extracellular	extracellular	ADJ
fnp-4899	24	9	matrix	matrix	NOUN
fnp-4899	24	10	(	(	PUNCT
fnp-4899	24	11	ecm	ecm	NOUN
fnp-4899	24	12	)	)	PUNCT
fnp-4899	24	13	proteins	protein	NOUN
fnp-4899	24	14	and	and	CCONJ
fnp-4899	24	15	associated	associated	ADJ
fnp-4899	24	16	factors	factor	NOUN
fnp-4899	24	17	and	and	CCONJ
fnp-4899	24	18	is	be	AUX
fnp-4899	24	19	a	a	DET
fnp-4899	24	20	complex	complex	ADJ
fnp-4899	24	21	network	network	NOUN
fnp-4899	24	22	of	of	ADP
fnp-4899	24	23	proteins	protein	NOUN
fnp-4899	24	24	and	and	CCONJ
fnp-4899	24	25	other	other	ADJ
fnp-4899	24	26	molecules	molecule	NOUN
fnp-4899	24	27	that	that	PRON
fnp-4899	24	28	provide	provide	VERB
fnp-4899	24	29	structural	structural	ADJ
fnp-4899	24	30	support	support	NOUN
fnp-4899	24	31	and	and	CCONJ
fnp-4899	24	32	regulate	regulate	VERB
fnp-4899	24	33	various	various	ADJ
fnp-4899	24	34	cellular	cellular	ADJ
fnp-4899	24	35	processes	process	NOUN
fnp-4899	24	36	.	.	PUNCT
fnp-4899	25	1	the	the	DET
fnp-4899	25	2	mapk	mapk	NOUN
fnp-4899	25	3	/	/	SYM
fnp-4899	25	4	metabolism	metabolism	NOUN
fnp-4899	25	5	module	module	NOUN
fnp-4899	25	6	was	be	AUX
fnp-4899	25	7	associated	associate	VERB
fnp-4899	25	8	with	with	ADP
fnp-4899	25	9	the	the	DET
fnp-4899	25	10	rate	rate	NOUN
fnp-4899	25	11	of	of	ADP
fnp-4899	25	12	cognitive	cognitive	ADJ
fnp-4899	25	13	decline	decline	NOUN
fnp-4899	25	14	whereas	whereas	SCONJ
fnp-4899	25	15	the	the	DET
fnp-4899	25	16	matrisome	matrisome	ADJ
fnp-4899	25	17	module	module	NOUN
fnp-4899	25	18	was	be	AUX
fnp-4899	25	19	influenced	influence	VERB
fnp-4899	25	20	by	by	ADP
fnp-4899	25	21	the	the	DET
fnp-4899	25	22	apoe	apoe	PROPN
fnp-4899	25	23	ε4	ε4	PROPN
fnp-4899	25	24	allele	allele	NOUN
fnp-4899	25	25	.	.	PUNCT
fnp-4899	26	1	these	these	DET
fnp-4899	26	2	results	result	NOUN
fnp-4899	26	3	indicate	indicate	VERB
fnp-4899	26	4	that	that	SCONJ
fnp-4899	26	5	pathways	pathway	NOUN
fnp-4899	26	6	that	that	PRON
fnp-4899	26	7	are	be	AUX
fnp-4899	26	8	unique	unique	ADJ
fnp-4899	26	9	to	to	ADP
fnp-4899	26	10	the	the	DET
fnp-4899	26	11	proteome	proteome	NOUN
fnp-4899	26	12	could	could	AUX
fnp-4899	26	13	lead	lead	VERB
fnp-4899	26	14	to	to	ADP
fnp-4899	26	15	therapeutic	therapeutic	ADJ
fnp-4899	26	16	targets	target	NOUN
fnp-4899	26	17	and	and	CCONJ
fnp-4899	26	18	biomarkers	biomarker	NOUN
fnp-4899	26	19	.	.	PUNCT
fnp-4899	27	1	figure	figure	NOUN
fnp-4899	27	2	1	1	NUM
fnp-4899	27	3	.	.	PUNCT
fnp-4899	28	1	tandem	tandem	PROPN
fnp-4899	28	2	mass	mass	PROPN
fnp-4899	28	3	tag	tag	PROPN
fnp-4899	28	4	mass	mass	NOUN
fnp-4899	28	5	spectrometry	spectrometry	NOUN
fnp-4899	28	6	(	(	PUNCT
fnp-4899	28	7	tmt	tmt	PROPN
fnp-4899	28	8	-	-	PUNCT
fnp-4899	28	9	ms	ms	PROPN
fnp-4899	28	10	)	)	PUNCT
fnp-4899	28	11	derived	derive	VERB
fnp-4899	28	12	alzheimer	alzheimer	NOUN
fnp-4899	28	13	disease	disease	NOUN
fnp-4899	28	14	protein	protein	NOUN
fnp-4899	28	15	network	network	NOUN
fnp-4899	28	16	contains	contain	VERB
fnp-4899	28	17	modules	module	NOUN
fnp-4899	28	18	that	that	PRON
fnp-4899	28	19	are	be	AUX
fnp-4899	28	20	not	not	PART
fnp-4899	28	21	present	present	ADJ
fnp-4899	28	22	in	in	ADP
fnp-4899	28	23	transcriptomic	transcriptomic	ADJ
fnp-4899	28	24	analysis	analysis	NOUN
fnp-4899	28	25	.	.	PUNCT
fnp-4899	29	1	a.	a.	NOUN
fnp-4899	29	2	experimental	experimental	ADJ
fnp-4899	29	3	overview	overview	NOUN
fnp-4899	29	4	.	.	PUNCT
fnp-4899	30	1	b.	b.	PROPN
fnp-4899	30	2	modules	module	NOUN
fnp-4899	30	3	that	that	PRON
fnp-4899	30	4	had	have	VERB
fnp-4899	30	5	a	a	DET
fnp-4899	30	6	zsummary	zsummary	ADJ
fnp-4899	30	7	score	score	NOUN
fnp-4899	30	8	greater	great	ADJ
fnp-4899	30	9	than	than	ADP
fnp-4899	30	10	or	or	CCONJ
fnp-4899	30	11	equal	equal	ADJ
fnp-4899	30	12	to	to	ADP
fnp-4899	30	13	1.96	1.96	NUM
fnp-4899	30	14	(	(	PUNCT
fnp-4899	30	15	or	or	CCONJ
fnp-4899	30	16	q	q	NOUN
fnp-4899	30	17	=	=	NOUN
fnp-4899	30	18	0.05	0.05	NUM
fnp-4899	30	19	,	,	PUNCT
fnp-4899	30	20	blue	blue	ADJ
fnp-4899	30	21	dotted	dotted	ADJ
fnp-4899	30	22	line	line	NOUN
fnp-4899	30	23	)	)	PUNCT
fnp-4899	30	24	were	be	AUX
fnp-4899	30	25	considered	consider	VERB
fnp-4899	30	26	to	to	PART
fnp-4899	30	27	be	be	AUX
fnp-4899	30	28	preserved	preserve	VERB
fnp-4899	30	29	.	.	PUNCT
fnp-4899	31	1	unique	unique	ADJ
fnp-4899	31	2	modules	module	NOUN
fnp-4899	31	3	included	include	VERB
fnp-4899	31	4	mapk	mapk	NOUN
fnp-4899	31	5	signaling	signal	VERB
fnp-4899	31	6	and	and	CCONJ
fnp-4899	31	7	the	the	DET
fnp-4899	31	8	matrisome	matrisome	PROPN
fnp-4899	31	9	(	(	PUNCT
fnp-4899	31	10	reproduced	reproduce	VERB
fnp-4899	31	11	from	from	ADP
fnp-4899	31	12	johnson	johnson	PROPN
fnp-4899	31	13	et	et	PROPN
fnp-4899	31	14	al	al	PROPN
fnp-4899	31	15	.	.	PROPN
fnp-4899	31	16	,	,	PUNCT
fnp-4899	31	17	2022	2022	NUM
fnp-4899	31	18	under	under	ADP
fnp-4899	31	19	the	the	DET
fnp-4899	31	20	creative	creative	ADJ
fnp-4899	31	21	commons	common	NOUN
fnp-4899	31	22	license	license	NOUN
fnp-4899	31	23	)	)	PUNCT
fnp-4899	31	24	.	.	PUNCT
fnp-4899	32	1	2	2	X
fnp-4899	32	2	.	.	X
fnp-4899	32	3	revision	revision	NOUN
fnp-4899	32	4	of	of	ADP
fnp-4899	32	5	the	the	DET
fnp-4899	32	6	neuropathological	neuropathological	ADJ
fnp-4899	32	7	criteria	criterion	NOUN
fnp-4899	32	8	for	for	ADP
fnp-4899	32	9	progressive	progressive	ADJ
fnp-4899	32	10	supranuclear	supranuclear	ADJ
fnp-4899	32	11	palsy	palsy	PROPN
fnp-4899	32	12	the	the	DET
fnp-4899	32	13	national	national	PROPN
fnp-4899	32	14	institute	institute	PROPN
fnp-4899	32	15	of	of	ADP
fnp-4899	32	16	neurological	neurological	ADJ
fnp-4899	32	17	disorders	disorder	NOUN
fnp-4899	32	18	and	and	CCONJ
fnp-4899	32	19	stroke	stroke	NOUN
fnp-4899	32	20	previously	previously	ADV
fnp-4899	32	21	advanced	advance	VERB
fnp-4899	32	22	neuropathologic	neuropathologic	ADJ
fnp-4899	32	23	criteria	criterion	NOUN
fnp-4899	32	24	for	for	ADP
fnp-4899	32	25	progressive	progressive	ADJ
fnp-4899	32	26	supranuclear	supranuclear	ADJ
fnp-4899	32	27	palsy	palsy	ADJ
fnp-4899	32	28	(	(	PUNCT
fnp-4899	32	29	psp	psp	NOUN
fnp-4899	32	30	)	)	PUNCT
fnp-4899	32	31	,	,	PUNCT
fnp-4899	32	32	which	which	PRON
fnp-4899	32	33	have	have	AUX
fnp-4899	32	34	been	be	AUX
fnp-4899	32	35	the	the	DET
fnp-4899	32	36	standard	standard	NOUN
fnp-4899	32	37	for	for	ADP
fnp-4899	32	38	nearly	nearly	ADV
fnp-4899	32	39	30	30	NUM
fnp-4899	32	40	years	year	NOUN
fnp-4899	32	41	.	.	PUNCT
fnp-4899	33	1	however	however	ADV
fnp-4899	33	2	,	,	PUNCT
fnp-4899	33	3	the	the	DET
fnp-4899	33	4	complex	complex	ADJ
fnp-4899	33	5	evaluation	evaluation	NOUN
fnp-4899	33	6	process	process	NOUN
fnp-4899	33	7	and	and	CCONJ
fnp-4899	33	8	dependence	dependence	NOUN
fnp-4899	33	9	on	on	ADP
fnp-4899	33	10	non	non	ADJ
fnp-4899	33	11	-	-	ADJ
fnp-4899	33	12	uniform	uniform	ADJ
fnp-4899	33	13	staining	stain	VERB
fnp-4899	33	14	methods	method	NOUN
fnp-4899	33	15	limited	limit	VERB
fnp-4899	33	16	the	the	DET
fnp-4899	33	17	utility	utility	NOUN
fnp-4899	33	18	of	of	ADP
fnp-4899	33	19	the	the	DET
fnp-4899	33	20	criteria	criterion	NOUN
fnp-4899	33	21	.	.	PUNCT
fnp-4899	34	1	since	since	SCONJ
fnp-4899	34	2	then	then	ADV
fnp-4899	34	3	,	,	PUNCT
fnp-4899	34	4	advancements	advancement	NOUN
fnp-4899	34	5	in	in	ADP
fnp-4899	34	6	immunohistochemistry	immunohistochemistry	NOUN
fnp-4899	34	7	and	and	CCONJ
fnp-4899	34	8	the	the	DET
fnp-4899	34	9	availability	availability	NOUN
fnp-4899	34	10	of	of	ADP
fnp-4899	34	11	specific	specific	ADJ
fnp-4899	34	12	antibodies	antibody	NOUN
fnp-4899	34	13	targeting	target	VERB
fnp-4899	34	14	pathological	pathological	ADJ
fnp-4899	34	15	tau	tau	NOUN
fnp-4899	34	16	proteins	protein	NOUN
fnp-4899	34	17	,	,	PUNCT
fnp-4899	34	18	especially	especially	ADV
fnp-4899	34	19	phosphorylation	phosphorylation	NOUN
fnp-4899	34	20	-	-	PUNCT
fnp-4899	34	21	dependent	dependent	ADJ
fnp-4899	34	22	epitopes	epitope	NOUN
fnp-4899	34	23	,	,	PUNCT
fnp-4899	34	24	have	have	AUX
fnp-4899	34	25	improved	improve	VERB
fnp-4899	34	26	the	the	DET
fnp-4899	34	27	recognition	recognition	NOUN
fnp-4899	34	28	of	of	ADP
fnp-4899	34	29	key	key	ADJ
fnp-4899	34	30	psp	psp	NOUN
fnp-4899	34	31	neuropathological	neuropathological	ADJ
fnp-4899	34	32	features	feature	NOUN
fnp-4899	34	33	,	,	PUNCT
fnp-4899	34	34	especially	especially	ADV
fnp-4899	34	35	tufted	tufte	VERB
fnp-4899	34	36	astrocytes	astrocyte	NOUN
fnp-4899	34	37	.	.	PUNCT
fnp-4899	35	1	further	far	ADV
fnp-4899	35	2	,	,	PUNCT
fnp-4899	35	3	new	new	ADJ
fnp-4899	35	4	diagnostic	diagnostic	ADJ
fnp-4899	35	5	entities	entity	NOUN
fnp-4899	35	6	have	have	AUX
fnp-4899	35	7	emerged	emerge	VERB
fnp-4899	35	8	,	,	PUNCT
fnp-4899	35	9	including	include	VERB
fnp-4899	35	10	chronic	chronic	ADJ
fnp-4899	35	11	traumatic	traumatic	ADJ
fnp-4899	35	12	encephalopathy	encephalopathy	NOUN
fnp-4899	35	13	(	(	PUNCT
fnp-4899	35	14	cte	cte	NOUN
fnp-4899	35	15	)	)	PUNCT
fnp-4899	35	16	,	,	PUNCT
fnp-4899	35	17	aging	age	VERB
fnp-4899	35	18	-	-	PUNCT
fnp-4899	35	19	related	relate	VERB
fnp-4899	35	20	tau	tau	PROPN
fnp-4899	35	21	astrogliopathy	astrogliopathy	ADJ
fnp-4899	35	22	(	(	PUNCT
fnp-4899	35	23	artag	artag	ADJ
fnp-4899	35	24	)	)	PUNCT
fnp-4899	35	25	and	and	CCONJ
fnp-4899	35	26	globular	globular	ADJ
fnp-4899	35	27	glial	glial	ADJ
fnp-4899	35	28	tauopathy	tauopathy	NOUN
fnp-4899	35	29	ggt	ggt	NOUN
fnp-4899	35	30	,	,	PUNCT
fnp-4899	35	31	which	which	PRON
fnp-4899	35	32	required	require	VERB
fnp-4899	35	33	better	well	ADJ
fnp-4899	35	34	delineation	delineation	NOUN
fnp-4899	35	35	from	from	ADP
fnp-4899	35	36	psp	psp	NOUN
fnp-4899	35	37	.	.	PUNCT
fnp-4899	36	1	to	to	PART
fnp-4899	36	2	update	update	VERB
fnp-4899	36	3	the	the	DET
fnp-4899	36	4	neuropathologic	neuropathologic	ADJ
fnp-4899	36	5	criteria	criterion	NOUN
fnp-4899	36	6	for	for	ADP
fnp-4899	36	7	psp	psp	NOUN
fnp-4899	36	8	,	,	PUNCT
fnp-4899	36	9	an	an	DET
fnp-4899	36	10	international	international	ADJ
fnp-4899	36	11	team	team	NOUN
fnp-4899	36	12	of	of	ADP
fnp-4899	36	13	neuropathologists	neuropathologist	NOUN
fnp-4899	36	14	,	,	PUNCT
fnp-4899	36	15	supported	support	VERB
fnp-4899	36	16	by	by	ADP
fnp-4899	36	17	the	the	DET
fnp-4899	36	18	rainwater	rainwater	NOUN
fnp-4899	36	19	charitable	charitable	ADJ
fnp-4899	36	20	foundation	foundation	PROPN
fnp-4899	36	21	/	/	SYM
fnp-4899	36	22	tau	tau	PROPN
fnp-4899	36	23	consortium	consortium	PROPN
fnp-4899	36	24	proposed	propose	VERB
fnp-4899	36	25	criteria	criterion	NOUN
fnp-4899	36	26	that	that	PRON
fnp-4899	36	27	incorporate	incorporate	VERB
fnp-4899	36	28	recent	recent	ADJ
fnp-4899	36	29	advancements	advancement	NOUN
fnp-4899	36	30	in	in	ADP
fnp-4899	36	31	tauopathies	tauopathie	NOUN
fnp-4899	36	32	and	and	CCONJ
fnp-4899	36	33	are	be	AUX
fnp-4899	36	34	easier	easy	ADJ
fnp-4899	36	35	to	to	PART
fnp-4899	36	36	apply	apply	VERB
fnp-4899	36	37	in	in	ADP
fnp-4899	36	38	non	non	ADJ
fnp-4899	36	39	-	-	ADJ
fnp-4899	36	40	specialized	specialized	ADJ
fnp-4899	36	41	clinical	clinical	ADJ
fnp-4899	36	42	settings	setting	NOUN
fnp-4899	36	43	(	(	PUNCT
fnp-4899	36	44	roemer	roemer	PROPN
fnp-4899	36	45	et	et	PROPN
fnp-4899	36	46	al	al	PROPN
fnp-4899	36	47	.	.	PROPN
fnp-4899	36	48	,	,	PUNCT
fnp-4899	36	49	2022	2022	NUM
fnp-4899	36	50	)	)	PUNCT
fnp-4899	36	51	.	.	PUNCT
fnp-4899	37	1	the	the	DET
fnp-4899	37	2	goal	goal	NOUN
fnp-4899	37	3	was	be	AUX
fnp-4899	37	4	to	to	PART
fnp-4899	37	5	develop	develop	VERB
fnp-4899	37	6	criteria	criterion	NOUN
fnp-4899	37	7	with	with	ADP
fnp-4899	37	8	high	high	ADJ
fnp-4899	37	9	sensitivity	sensitivity	NOUN
fnp-4899	37	10	,	,	PUNCT
fnp-4899	37	11	specificity	specificity	NOUN
fnp-4899	37	12	,	,	PUNCT
fnp-4899	37	13	and	and	CCONJ
fnp-4899	37	14	inter	inter	ADJ
fnp-4899	37	15	-	-	ADJ
fnp-4899	37	16	rater	rater	ADJ
fnp-4899	37	17	agreement	agreement	NOUN
fnp-4899	37	18	,	,	PUNCT
fnp-4899	37	19	even	even	ADV
fnp-4899	37	20	for	for	ADP
fnp-4899	37	21	atypical	atypical	ADJ
fnp-4899	37	22	variants	variant	NOUN
fnp-4899	37	23	of	of	ADP
fnp-4899	37	24	psp	psp	NOUN
fnp-4899	37	25	,	,	PUNCT
fnp-4899	37	26	while	while	SCONJ
fnp-4899	37	27	being	be	AUX
fnp-4899	37	28	independent	independent	ADJ
fnp-4899	37	29	of	of	ADP
fnp-4899	37	30	clinical	clinical	ADJ
fnp-4899	37	31	information	information	NOUN
fnp-4899	37	32	and	and	CCONJ
fnp-4899	37	33	suitable	suitable	ADJ
fnp-4899	37	34	for	for	ADP
fnp-4899	37	35	non	non	ADJ
fnp-4899	37	36	-	-	ADJ
fnp-4899	37	37	specialized	specialized	ADJ
fnp-4899	37	38	neuropathology	neuropathology	NOUN
fnp-4899	37	39	services	service	NOUN
fnp-4899	37	40	.	.	PUNCT
fnp-4899	38	1	the	the	DET
fnp-4899	38	2	investigators	investigator	NOUN
fnp-4899	38	3	evaluated	evaluate	VERB
fnp-4899	38	4	digital	digital	ADJ
fnp-4899	38	5	slides	slide	NOUN
fnp-4899	38	6	from	from	ADP
fnp-4899	38	7	10	10	NUM
fnp-4899	38	8	brain	brain	NOUN
fnp-4899	38	9	regions	region	NOUN
fnp-4899	38	10	stained	stain	VERB
fnp-4899	38	11	with	with	ADP
fnp-4899	38	12	hematoxylin	hematoxylin	NOUN
fnp-4899	38	13	and	and	CCONJ
fnp-4899	38	14	eosin	eosin	NOUN
fnp-4899	38	15	and	and	CCONJ
fnp-4899	38	16	phosphorylated	phosphorylate	VERB
fnp-4899	38	17	tau	tau	PROPN
fnp-4899	38	18	(	(	PUNCT
fnp-4899	38	19	at8	at8	PROPN
fnp-4899	38	20	)	)	PUNCT
fnp-4899	38	21	immunohistochemistry	immunohistochemistry	NOUN
fnp-4899	38	22	for	for	ADP
fnp-4899	38	23	15	15	NUM
fnp-4899	38	24	typical	typical	ADJ
fnp-4899	38	25	and	and	CCONJ
fnp-4899	38	26	atypical	atypical	ADJ
fnp-4899	38	27	psp	psp	NOUN
fnp-4899	38	28	cases	case	NOUN
fnp-4899	38	29	and	and	CCONJ
fnp-4899	38	30	10	10	NUM
fnp-4899	38	31	other	other	ADJ
fnp-4899	38	32	tauopathies	tauopathie	NOUN
fnp-4899	38	33	.	.	PUNCT
fnp-4899	39	1	blinded	blind	VERB
fnp-4899	39	2	to	to	ADP
fnp-4899	39	3	clinical	clinical	ADJ
fnp-4899	39	4	and	and	CCONJ
fnp-4899	39	5	neuropathological	neuropathological	ADJ
fnp-4899	39	6	information	information	NOUN
fnp-4899	39	7	,	,	PUNCT
fnp-4899	39	8	14	14	NUM
fnp-4899	39	9	expert	expert	NOUN
fnp-4899	39	10	neuropathologists	neuropathologist	NOUN
fnp-4899	39	11	provided	provide	VERB
fnp-4899	39	12	a	a	DET
fnp-4899	39	13	categorical	categorical	ADJ
fnp-4899	39	14	diagnosis	diagnosis	NOUN
fnp-4899	39	15	(	(	PUNCT
fnp-4899	39	16	psp	psp	NOUN
fnp-4899	39	17	or	or	CCONJ
fnp-4899	39	18	not	not	PART
fnp-4899	39	19	-	-	PUNCT
fnp-4899	39	20	psp	psp	NOUN
fnp-4899	39	21	)	)	PUNCT
fnp-4899	39	22	based	base	VERB
fnp-4899	39	23	on	on	ADP
fnp-4899	39	24	provisional	provisional	ADJ
fnp-4899	39	25	criteria	criterion	NOUN
fnp-4899	39	26	requiring	require	VERB
fnp-4899	39	27	neurofibrillary	neurofibrillary	ADJ
fnp-4899	39	28	tangles	tangle	NOUN
fnp-4899	39	29	or	or	CCONJ
fnp-4899	39	30	pretangles	pretangle	NOUN
fnp-4899	39	31	in	in	ADP
fnp-4899	39	32	two	two	NUM
fnp-4899	39	33	of	of	ADP
fnp-4899	39	34	three	three	NUM
fnp-4899	39	35	regions	region	NOUN
fnp-4899	39	36	and	and	CCONJ
fnp-4899	39	37	tufted	tufte	VERB
fnp-4899	39	38	astrocytes	astrocyte	NOUN
fnp-4899	39	39	in	in	ADP
fnp-4899	39	40	one	one	NUM
fnp-4899	39	41	of	of	ADP
fnp-4899	39	42	two	two	NUM
fnp-4899	39	43	regions	region	NOUN
fnp-4899	39	44	.	.	PUNCT
fnp-4899	40	1	the	the	DET
fnp-4899	40	2	provisional	provisional	ADJ
fnp-4899	40	3	criteria	criterion	NOUN
fnp-4899	40	4	had	have	VERB
fnp-4899	40	5	high	high	ADJ
fnp-4899	40	6	sensitivity	sensitivity	NOUN
fnp-4899	40	7	(	(	PUNCT
fnp-4899	40	8	0.97	0.97	NUM
fnp-4899	40	9	)	)	PUNCT
fnp-4899	40	10	and	and	CCONJ
fnp-4899	40	11	specificity	specificity	NOUN
fnp-4899	40	12	(	(	PUNCT
fnp-4899	40	13	0.91	0.91	NUM
fnp-4899	40	14	)	)	PUNCT
fnp-4899	40	15	,	,	PUNCT
fnp-4899	40	16	as	as	ADV
fnp-4899	40	17	well	well	ADV
fnp-4899	40	18	as	as	ADP
fnp-4899	40	19	almost	almost	ADV
fnp-4899	40	20	perfect	perfect	ADJ
fnp-4899	40	21	inter	inter	ADJ
fnp-4899	40	22	-	-	ADJ
fnp-4899	40	23	rater	rater	ADJ
fnp-4899	40	24	reliability	reliability	NOUN
fnp-4899	40	25	for	for	ADP
fnp-4899	40	26	diagnosing	diagnose	VERB
fnp-4899	40	27	psp	psp	NOUN
fnp-4899	40	28	and	and	CCONJ
fnp-4899	40	29	differentiating	differentiate	VERB
fnp-4899	40	30	it	it	PRON
fnp-4899	40	31	from	from	ADP
fnp-4899	40	32	other	other	ADJ
fnp-4899	40	33	tauopathies	tauopathie	NOUN
fnp-4899	40	34	.	.	PUNCT
fnp-4899	41	1	the	the	DET
fnp-4899	41	2	rainwater	rainwater	NOUN
fnp-4899	41	3	charitable	charitable	ADJ
fnp-4899	41	4	foundation	foundation	NOUN
fnp-4899	41	5	criteria	criterion	NOUN
fnp-4899	41	6	for	for	ADP
fnp-4899	41	7	the	the	DET
fnp-4899	41	8	neuropathologic	neuropathologic	ADJ
fnp-4899	41	9	diagnosis	diagnosis	NOUN
fnp-4899	41	10	of	of	ADP
fnp-4899	41	11	psp	psp	NOUN
fnp-4899	41	12	feature	feature	NOUN
fnp-4899	41	13	a	a	DET
fnp-4899	41	14	simplified	simplified	ADJ
fnp-4899	41	15	diagnostic	diagnostic	ADJ
fnp-4899	41	16	algorithm	algorithm	NOUN
fnp-4899	41	17	based	base	VERB
fnp-4899	41	18	on	on	ADP
fnp-4899	41	19	phosphorylated	phosphorylate	VERB
fnp-4899	41	20	tau	tau	PROPN
fnp-4899	41	21	immunohistochemistry	immunohistochemistry	NOUN
fnp-4899	41	22	and	and	CCONJ
fnp-4899	41	23	incorporate	incorporate	VERB
fnp-4899	41	24	tufted	tufted	ADJ
fnp-4899	41	25	astrocytes	astrocyte	NOUN
fnp-4899	41	26	as	as	ADP
fnp-4899	41	27	an	an	DET
fnp-4899	41	28	essential	essential	ADJ
fnp-4899	41	29	diagnostic	diagnostic	ADJ
fnp-4899	41	30	feature	feature	NOUN
fnp-4899	41	31	(	(	PUNCT
fnp-4899	41	32	figure	figure	NOUN
fnp-4899	41	33	2	2	NUM
fnp-4899	41	34	)	)	PUNCT
fnp-4899	41	35	.	.	PUNCT
fnp-4899	42	1	figure	figure	NOUN
fnp-4899	42	2	2	2	NUM
fnp-4899	42	3	.	.	PUNCT
fnp-4899	42	4	rainwater	rainwater	NOUN
fnp-4899	42	5	neuropathological	neuropathological	ADJ
fnp-4899	42	6	criteria	criterion	NOUN
fnp-4899	42	7	for	for	ADP
fnp-4899	42	8	progressive	progressive	ADJ
fnp-4899	42	9	supranuclear	supranuclear	ADJ
fnp-4899	42	10	palsy	palsy	PROPN
fnp-4899	42	11	.	.	PUNCT
fnp-4899	43	1	a.	a.	NOUN
fnp-4899	44	1	the	the	DET
fnp-4899	44	2	minimum	minimum	ADJ
fnp-4899	44	3	requirements	requirement	NOUN
fnp-4899	44	4	are	be	AUX
fnp-4899	44	5	demonstration	demonstration	NOUN
fnp-4899	44	6	of	of	ADP
fnp-4899	44	7	neurofibrillary	neurofibrillary	ADJ
fnp-4899	44	8	tangles	tangle	NOUN
fnp-4899	44	9	in	in	ADP
fnp-4899	44	10	two	two	NUM
fnp-4899	44	11	any	any	PRON
fnp-4899	44	12	of	of	ADP
fnp-4899	44	13	three	three	NUM
fnp-4899	44	14	classically	classically	ADV
fnp-4899	44	15	involved	involve	VERB
fnp-4899	44	16	regions	region	NOUN
fnp-4899	44	17	(	(	PUNCT
fnp-4899	44	18	e.g.	e.g.	ADV
fnp-4899	44	19	,	,	PUNCT
fnp-4899	44	20	the	the	DET
fnp-4899	44	21	subthalamic	subthalamic	ADJ
fnp-4899	44	22	nucleus	nucleus	NOUN
fnp-4899	44	23	,	,	PUNCT
fnp-4899	44	24	globus	globus	NOUN
fnp-4899	44	25	pallidus	pallidus	NOUN
fnp-4899	44	26	,	,	PUNCT
fnp-4899	44	27	and	and	CCONJ
fnp-4899	44	28	substantia	substantia	NOUN
fnp-4899	44	29	nigra	nigra	NOUN
fnp-4899	44	30	)	)	PUNCT
fnp-4899	44	31	alongside	alongside	ADP
fnp-4899	44	32	tufted	tufte	VERB
fnp-4899	44	33	astrocytes	astrocyte	NOUN
fnp-4899	44	34	in	in	ADP
fnp-4899	44	35	the	the	DET
fnp-4899	44	36	putamen	putaman	NOUN
fnp-4899	44	37	or	or	CCONJ
fnp-4899	44	38	peri	peri	NOUN
fnp-4899	44	39	-	-	PUNCT
fnp-4899	44	40	rolandic	rolandic	NOUN
fnp-4899	44	41	cortex	cortex	NOUN
fnp-4899	44	42	.	.	PUNCT
fnp-4899	45	1	b.	b.	PROPN
fnp-4899	45	2	examples	example	NOUN
fnp-4899	45	3	of	of	ADP
fnp-4899	45	4	neurofibrillary	neurofibrillary	ADJ
fnp-4899	45	5	tangles	tangle	NOUN
fnp-4899	45	6	and	and	CCONJ
fnp-4899	45	7	tufted	tufte	VERB
fnp-4899	45	8	astrocytes	astrocyte	NOUN
fnp-4899	45	9	on	on	ADP
fnp-4899	45	10	phospho	phospho	NOUN
fnp-4899	45	11	-	-	PUNCT
fnp-4899	45	12	tau	tau	PROPN
fnp-4899	45	13	(	(	PUNCT
fnp-4899	45	14	at8	at8	PROPN
fnp-4899	45	15	antisera	antisera	PROPN
fnp-4899	45	16	)	)	PUNCT
fnp-4899	45	17	immunohistochemical	immunohistochemical	ADJ
fnp-4899	45	18	staining	stain	VERB
fnp-4899	45	19	(	(	PUNCT
fnp-4899	45	20	reproduced	reproduce	VERB
fnp-4899	45	21	with	with	ADP
fnp-4899	45	22	permission	permission	NOUN
fnp-4899	45	23	from	from	ADP
fnp-4899	45	24	roemer	roemer	PROPN
fnp-4899	45	25	et	et	PROPN
fnp-4899	45	26	al	al	PROPN
fnp-4899	45	27	.	.	PROPN
fnp-4899	45	28	,	,	PUNCT
fnp-4899	45	29	2022	2022	NUM
fnp-4899	45	30	under	under	ADP
fnp-4899	45	31	the	the	DET
fnp-4899	45	32	creative	creative	ADJ
fnp-4899	45	33	commons	common	NOUN
fnp-4899	45	34	license	license	NOUN
fnp-4899	45	35	)	)	PUNCT
fnp-4899	45	36	.	.	PUNCT
fnp-4899	46	1	3	3	X
fnp-4899	46	2	.	.	X
fnp-4899	46	3	limbic	limbic	NOUN
fnp-4899	46	4	-	-	PUNCT
fnp-4899	46	5	predominant	predominant	ADJ
fnp-4899	46	6	age	age	NOUN
fnp-4899	46	7	-	-	PUNCT
fnp-4899	46	8	related	relate	VERB
fnp-4899	46	9	tdp-43	tdp-43	NOUN
fnp-4899	46	10	encephalopathy	encephalopathy	ADJ
fnp-4899	46	11	and	and	CCONJ
fnp-4899	46	12	alzheimer	alzheimer	NOUN
fnp-4899	46	13	disease	disease	NOUN
fnp-4899	46	14	:	:	PUNCT
fnp-4899	46	15	the	the	DET
fnp-4899	46	16	impact	impact	NOUN
fnp-4899	46	17	of	of	ADP
fnp-4899	46	18	coexistence	coexistence	NOUN
fnp-4899	46	19	on	on	ADP
fnp-4899	46	20	cognition	cognition	NOUN
fnp-4899	46	21	limbic	limbic	NOUN
fnp-4899	46	22	-	-	PUNCT
fnp-4899	46	23	predominant	predominant	ADJ
fnp-4899	46	24	age	age	NOUN
fnp-4899	46	25	-	-	PUNCT
fnp-4899	46	26	related	relate	VERB
fnp-4899	46	27	tdp-43	tdp-43	NOUN
fnp-4899	46	28	encephalopathy	encephalopathy	ADJ
fnp-4899	46	29	neuropathologic	neuropathologic	ADJ
fnp-4899	46	30	change	change	NOUN
fnp-4899	46	31	(	(	PUNCT
fnp-4899	46	32	late	late	PROPN
fnp-4899	46	33	-	-	PUNCT
fnp-4899	46	34	nc	nc	NOUN
fnp-4899	46	35	)	)	PUNCT
fnp-4899	46	36	and	and	CCONJ
fnp-4899	46	37	alzheimer	alzheimer	PROPN
fnp-4899	46	38	disease	disease	PROPN
fnp-4899	46	39	neuropathologic	neuropathologic	PROPN
fnp-4899	46	40	change	change	NOUN
fnp-4899	46	41	(	(	PUNCT
fnp-4899	46	42	adnc	adnc	ADJ
fnp-4899	46	43	)	)	PUNCT
fnp-4899	46	44	are	be	AUX
fnp-4899	46	45	both	both	PRON
fnp-4899	46	46	implicated	implicate	VERB
fnp-4899	46	47	in	in	ADP
fnp-4899	46	48	cognitive	cognitive	ADJ
fnp-4899	46	49	impairment	impairment	NOUN
fnp-4899	46	50	among	among	ADP
fnp-4899	46	51	older	old	ADJ
fnp-4899	46	52	individuals	individual	NOUN
fnp-4899	46	53	.	.	PUNCT
fnp-4899	47	1	however	however	ADV
fnp-4899	47	2	,	,	PUNCT
fnp-4899	47	3	the	the	DET
fnp-4899	47	4	frequency	frequency	NOUN
fnp-4899	47	5	of	of	ADP
fnp-4899	47	6	late	late	PROPN
fnp-4899	47	7	-	-	PUNCT
fnp-4899	47	8	nc	nc	NOUN
fnp-4899	47	9	across	across	ADP
fnp-4899	47	10	the	the	DET
fnp-4899	47	11	entire	entire	ADJ
fnp-4899	47	12	range	range	NOUN
fnp-4899	47	13	of	of	ADP
fnp-4899	47	14	adnc	adnc	ADJ
fnp-4899	47	15	remains	remain	VERB
fnp-4899	47	16	uncertain	uncertain	ADJ
fnp-4899	47	17	.	.	PUNCT
fnp-4899	48	1	to	to	PART
fnp-4899	48	2	address	address	VERB
fnp-4899	48	3	this	this	DET
fnp-4899	48	4	gap	gap	NOUN
fnp-4899	48	5	in	in	ADP
fnp-4899	48	6	knowledge	knowledge	NOUN
fnp-4899	48	7	,	,	PUNCT
fnp-4899	48	8	nelson	nelson	PROPN
fnp-4899	48	9	et	et	PROPN
fnp-4899	48	10	al	al	PROPN
fnp-4899	48	11	.	.	PROPN
fnp-4899	48	12	performed	perform	VERB
fnp-4899	48	13	a	a	DET
fnp-4899	48	14	comprehensive	comprehensive	ADJ
fnp-4899	48	15	analysis	analysis	NOUN
fnp-4899	48	16	from	from	ADP
fnp-4899	48	17	13	13	NUM
fnp-4899	48	18	high	high	ADJ
fnp-4899	48	19	-	-	PUNCT
fnp-4899	48	20	quality	quality	NOUN
fnp-4899	48	21	longitudinal	longitudinal	ADJ
fnp-4899	48	22	studies	study	NOUN
fnp-4899	48	23	,	,	PUNCT
fnp-4899	48	24	encompassing	encompass	VERB
fnp-4899	48	25	a	a	DET
fnp-4899	48	26	total	total	NOUN
fnp-4899	48	27	of	of	ADP
fnp-4899	48	28	6,196	6,196	NUM
fnp-4899	48	29	participants	participant	NOUN
fnp-4899	48	30	from	from	ADP
fnp-4899	48	31	diverse	diverse	ADJ
fnp-4899	48	32	countries	country	NOUN
fnp-4899	48	33	(	(	PUNCT
fnp-4899	48	34	nelson	nelson	PROPN
fnp-4899	48	35	et	et	PROPN
fnp-4899	48	36	al	al	PROPN
fnp-4899	48	37	.	.	PROPN
fnp-4899	48	38	,	,	PUNCT
fnp-4899	48	39	2022	2022	NUM
fnp-4899	48	40	)	)	PUNCT
fnp-4899	48	41	.	.	PUNCT
fnp-4899	49	1	among	among	ADP
fnp-4899	49	2	individuals	individual	NOUN
fnp-4899	49	3	with	with	ADP
fnp-4899	49	4	documented	document	VERB
fnp-4899	49	5	cognitive	cognitive	ADJ
fnp-4899	49	6	status	status	NOUN
fnp-4899	49	7	prior	prior	ADV
fnp-4899	49	8	to	to	ADP
fnp-4899	49	9	death	death	NOUN
fnp-4899	49	10	,	,	PUNCT
fnp-4899	49	11	43.0	43.0	NUM
fnp-4899	49	12	%	%	NOUN
fnp-4899	49	13	were	be	AUX
fnp-4899	49	14	found	find	VERB
fnp-4899	49	15	to	to	PART
fnp-4899	49	16	be	be	AUX
fnp-4899	49	17	cognitively	cognitively	ADV
fnp-4899	49	18	normal	normal	ADJ
fnp-4899	49	19	,	,	PUNCT
fnp-4899	49	20	14.9	14.9	NUM
fnp-4899	49	21	%	%	NOUN
fnp-4899	49	22	had	have	VERB
fnp-4899	49	23	mild	mild	ADJ
fnp-4899	49	24	cognitive	cognitive	ADJ
fnp-4899	49	25	impairment	impairment	NOUN
fnp-4899	49	26	,	,	PUNCT
fnp-4899	49	27	and	and	CCONJ
fnp-4899	49	28	42.4	42.4	NUM
fnp-4899	49	29	%	%	NOUN
fnp-4899	49	30	had	have	VERB
fnp-4899	49	31	dementia	dementia	NOUN
fnp-4899	49	32	,	,	PUNCT
fnp-4899	49	33	consistent	consistent	ADJ
fnp-4899	49	34	with	with	ADP
fnp-4899	49	35	epidemiological	epidemiological	ADJ
fnp-4899	49	36	data	datum	NOUN
fnp-4899	49	37	for	for	ADP
fnp-4899	49	38	this	this	DET
fnp-4899	49	39	age	age	NOUN
fnp-4899	49	40	range	range	NOUN
fnp-4899	49	41	.	.	PUNCT
fnp-4899	50	1	in	in	ADP
fnp-4899	50	2	cases	case	NOUN
fnp-4899	50	3	with	with	ADP
fnp-4899	50	4	available	available	ADJ
fnp-4899	50	5	cerad	cerad	PROPN
fnp-4899	50	6	neuritic	neuritic	ADJ
fnp-4899	50	7	amyloid	amyloid	NOUN
fnp-4899	50	8	plaque	plaque	NOUN
fnp-4899	50	9	score	score	NOUN
fnp-4899	50	10	data	datum	NOUN
fnp-4899	50	11	,	,	PUNCT
fnp-4899	50	12	39.4	39.4	NUM
fnp-4899	50	13	%	%	NOUN
fnp-4899	50	14	were	be	AUX
fnp-4899	50	15	confirmed	confirm	VERB
fnp-4899	50	16	to	to	PART
fnp-4899	50	17	have	have	VERB
fnp-4899	50	18	late	late	ADJ
fnp-4899	50	19	-	-	PUNCT
fnp-4899	50	20	nc	nc	NOUN
fnp-4899	50	21	at	at	ADP
fnp-4899	50	22	any	any	DET
fnp-4899	50	23	stage	stage	NOUN
fnp-4899	50	24	based	base	VERB
fnp-4899	50	25	on	on	ADP
fnp-4899	50	26	autopsy	autopsy	ADJ
fnp-4899	50	27	findings	finding	NOUN
fnp-4899	50	28	.	.	PUNCT
fnp-4899	51	1	notably	notably	ADV
fnp-4899	51	2	,	,	PUNCT
fnp-4899	51	3	among	among	ADP
fnp-4899	51	4	brains	brain	NOUN
fnp-4899	51	5	with	with	ADP
fnp-4899	51	6	"	"	PUNCT
fnp-4899	51	7	frequent	frequent	ADJ
fnp-4899	51	8	"	"	PUNCT
fnp-4899	51	9	neuritic	neuritic	ADJ
fnp-4899	51	10	amyloid	amyloid	NOUN
fnp-4899	51	11	plaques	plaque	NOUN
fnp-4899	51	12	,	,	PUNCT
fnp-4899	51	13	54.9	54.9	NUM
fnp-4899	51	14	%	%	NOUN
fnp-4899	51	15	exhibited	exhibit	VERB
fnp-4899	51	16	concurrent	concurrent	ADJ
fnp-4899	51	17	late	late	ADJ
fnp-4899	51	18	-	-	PUNCT
fnp-4899	51	19	nc	nc	PROPN
fnp-4899	51	20	,	,	PUNCT
fnp-4899	51	21	while	while	SCONJ
fnp-4899	51	22	27.0	27.0	NUM
fnp-4899	51	23	%	%	NOUN
fnp-4899	51	24	of	of	ADP
fnp-4899	51	25	brains	brain	NOUN
fnp-4899	51	26	lacking	lack	VERB
fnp-4899	51	27	detectable	detectable	ADJ
fnp-4899	51	28	neuritic	neuritic	ADJ
fnp-4899	51	29	amyloid	amyloid	NOUN
fnp-4899	51	30	plaques	plaque	NOUN
fnp-4899	51	31	displayed	display	VERB
fnp-4899	51	32	late	late	ADJ
fnp-4899	51	33	-	-	PUNCT
fnp-4899	51	34	nc	nc	PROPN
fnp-4899	51	35	.	.	PROPN
fnp-4899	52	1	remarkably	remarkably	ADV
fnp-4899	52	2	,	,	PUNCT
fnp-4899	52	3	late	late	PROPN
fnp-4899	52	4	-	-	PUNCT
fnp-4899	52	5	nc	nc	PROPN
fnp-4899	52	6	was	be	AUX
fnp-4899	52	7	present	present	ADJ
fnp-4899	52	8	in	in	ADP
fnp-4899	52	9	nearly	nearly	ADV
fnp-4899	52	10	40	40	NUM
fnp-4899	52	11	%	%	NOUN
fnp-4899	52	12	of	of	ADP
fnp-4899	52	13	participants	participant	NOUN
fnp-4899	52	14	and	and	CCONJ
fnp-4899	52	15	often	often	ADV
fnp-4899	52	16	coexisted	coexist	VERB
fnp-4899	52	17	with	with	ADP
fnp-4899	52	18	adnc	adnc	ADJ
fnp-4899	52	19	.	.	PUNCT
fnp-4899	53	1	detailed	detailed	ADJ
fnp-4899	53	2	neurocognitive	neurocognitive	ADJ
fnp-4899	53	3	assessments	assessment	NOUN
fnp-4899	53	4	conducted	conduct	VERB
fnp-4899	53	5	proximate	proximate	NOUN
fnp-4899	53	6	to	to	ADP
fnp-4899	53	7	death	death	NOUN
fnp-4899	53	8	across	across	ADP
fnp-4899	53	9	10	10	NUM
fnp-4899	53	10	cohorts	cohort	NOUN
fnp-4899	53	11	demonstrated	demonstrate	VERB
fnp-4899	53	12	a	a	DET
fnp-4899	53	13	tendency	tendency	NOUN
fnp-4899	53	14	for	for	ADP
fnp-4899	53	15	worse	bad	ADJ
fnp-4899	53	16	cognition	cognition	NOUN
fnp-4899	53	17	in	in	ADP
fnp-4899	53	18	individuals	individual	NOUN
fnp-4899	53	19	with	with	ADP
fnp-4899	53	20	late	late	ADJ
fnp-4899	53	21	-	-	PUNCT
fnp-4899	53	22	nc	nc	NOUN
fnp-4899	53	23	across	across	ADP
fnp-4899	53	24	the	the	DET
fnp-4899	53	25	entire	entire	ADJ
fnp-4899	53	26	range	range	NOUN
fnp-4899	53	27	of	of	ADP
fnp-4899	53	28	adnc	adnc	ADJ
fnp-4899	53	29	severity	severity	NOUN
fnp-4899	53	30	.	.	PUNCT
fnp-4899	54	1	none	none	NOUN
fnp-4899	54	2	of	of	ADP
fnp-4899	54	3	the	the	DET
fnp-4899	54	4	participants	participant	NOUN
fnp-4899	54	5	received	receive	VERB
fnp-4899	54	6	a	a	DET
fnp-4899	54	7	clinical	clinical	ADJ
fnp-4899	54	8	diagnosis	diagnosis	NOUN
fnp-4899	54	9	of	of	ADP
fnp-4899	54	10	definite	definite	ADJ
fnp-4899	54	11	frontotemporal	frontotemporal	ADJ
fnp-4899	54	12	dementia	dementia	NOUN
fnp-4899	54	13	or	or	CCONJ
fnp-4899	54	14	a	a	DET
fnp-4899	54	15	pathological	pathological	ADJ
fnp-4899	54	16	diagnosis	diagnosis	NOUN
fnp-4899	54	17	of	of	ADP
fnp-4899	54	18	frontotemporal	frontotemporal	ADJ
fnp-4899	54	19	lobar	lobar	ADJ
fnp-4899	54	20	degeneration	degeneration	NOUN
fnp-4899	54	21	with	with	ADP
fnp-4899	54	22	tdp-43	tdp-43	NOUN
fnp-4899	54	23	inclusions	inclusion	NOUN
fnp-4899	54	24	.	.	PUNCT
fnp-4899	55	1	these	these	DET
fnp-4899	55	2	findings	finding	NOUN
fnp-4899	55	3	provide	provide	VERB
fnp-4899	55	4	valuable	valuable	ADJ
fnp-4899	55	5	insights	insight	NOUN
fnp-4899	55	6	into	into	ADP
fnp-4899	55	7	the	the	DET
fnp-4899	55	8	prevalence	prevalence	NOUN
fnp-4899	55	9	and	and	CCONJ
fnp-4899	55	10	interplay	interplay	NOUN
fnp-4899	55	11	between	between	ADP
fnp-4899	55	12	late	late	PROPN
fnp-4899	55	13	-	-	PUNCT
fnp-4899	55	14	nc	nc	PROPN
fnp-4899	55	15	and	and	CCONJ
fnp-4899	55	16	adnc	adnc	ADJ
fnp-4899	55	17	,	,	PUNCT
fnp-4899	55	18	highlighting	highlight	VERB
fnp-4899	55	19	their	their	PRON
fnp-4899	55	20	impact	impact	NOUN
fnp-4899	55	21	on	on	ADP
fnp-4899	55	22	cognitive	cognitive	ADJ
fnp-4899	55	23	function	function	NOUN
fnp-4899	55	24	in	in	ADP
fnp-4899	55	25	the	the	DET
fnp-4899	55	26	aging	age	VERB
fnp-4899	55	27	population	population	NOUN
fnp-4899	55	28	.	.	PUNCT
fnp-4899	56	1	figure	figure	VERB
fnp-4899	56	2	3	3	NUM
fnp-4899	56	3	.	.	PUNCT
fnp-4899	56	4	frequency	frequency	NOUN
fnp-4899	56	5	of	of	ADP
fnp-4899	56	6	limbic	limbic	ADJ
fnp-4899	56	7	-	-	PUNCT
fnp-4899	56	8	predominant	predominant	ADJ
fnp-4899	56	9	age	age	NOUN
fnp-4899	56	10	-	-	PUNCT
fnp-4899	56	11	related	relate	VERB
fnp-4899	56	12	tdp-43	tdp-43	NOUN
fnp-4899	56	13	encephalopathy	encephalopathy	ADJ
fnp-4899	56	14	neuropathologic	neuropathologic	ADJ
fnp-4899	56	15	change	change	NOUN
fnp-4899	56	16	(	(	PUNCT
fnp-4899	56	17	late	late	PROPN
fnp-4899	56	18	-	-	PUNCT
fnp-4899	56	19	nc	nc	NOUN
fnp-4899	56	20	)	)	PUNCT
fnp-4899	56	21	across	across	ADP
fnp-4899	56	22	the	the	DET
fnp-4899	56	23	entire	entire	ADJ
fnp-4899	56	24	range	range	NOUN
fnp-4899	56	25	of	of	ADP
fnp-4899	56	26	alzheimer	alzheimer	PROPN
fnp-4899	56	27	disease	disease	PROPN
fnp-4899	56	28	neuropathologic	neuropathologic	PROPN
fnp-4899	56	29	change	change	NOUN
fnp-4899	56	30	(	(	PUNCT
fnp-4899	56	31	adnc	adnc	ADJ
fnp-4899	56	32	)	)	PUNCT
fnp-4899	56	33	.	.	PUNCT
fnp-4899	57	1	in	in	ADP
fnp-4899	57	2	participants	participant	NOUN
fnp-4899	57	3	with	with	ADP
fnp-4899	57	4	minimal	minimal	ADJ
fnp-4899	57	5	adnc	adnc	ADJ
fnp-4899	57	6	,	,	PUNCT
fnp-4899	57	7	~25	~25	NUM
fnp-4899	57	8	%	%	NOUN
fnp-4899	57	9	have	have	VERB
fnp-4899	57	10	late	late	ADJ
fnp-4899	57	11	-	-	PUNCT
fnp-4899	57	12	nc	nc	PROPN
fnp-4899	57	13	,	,	PUNCT
fnp-4899	57	14	suggesting	suggest	VERB
fnp-4899	57	15	adnc	adnc	ADJ
fnp-4899	57	16	-	-	PUNCT
fnp-4899	57	17	independent	independent	ADJ
fnp-4899	57	18	mechanisms	mechanism	NOUN
fnp-4899	57	19	.	.	PUNCT
fnp-4899	58	1	late	late	PROPN
fnp-4899	58	2	-	-	PUNCT
fnp-4899	58	3	nc	nc	PROPN
fnp-4899	58	4	is	be	AUX
fnp-4899	58	5	associated	associate	VERB
fnp-4899	58	6	with	with	ADP
fnp-4899	58	7	more	more	ADV
fnp-4899	58	8	severe	severe	ADJ
fnp-4899	58	9	primary	primary	ADJ
fnp-4899	58	10	age	age	NOUN
fnp-4899	58	11	-	-	PUNCT
fnp-4899	58	12	related	relate	VERB
fnp-4899	58	13	tauopathy	tauopathy	ADJ
fnp-4899	58	14	pathology	pathology	NOUN
fnp-4899	58	15	,	,	PUNCT
fnp-4899	58	16	indicating	indicate	VERB
fnp-4899	58	17	potential	potential	ADJ
fnp-4899	58	18	synergy	synergy	NOUN
fnp-4899	58	19	.	.	PUNCT
fnp-4899	59	1	in	in	ADP
fnp-4899	59	2	subjects	subject	NOUN
fnp-4899	59	3	with	with	ADP
fnp-4899	59	4	severe	severe	ADJ
fnp-4899	59	5	adnc	adnc	ADJ
fnp-4899	59	6	,	,	PUNCT
fnp-4899	59	7	approximately	approximately	ADV
fnp-4899	59	8	50	50	NUM
fnp-4899	59	9	%	%	NOUN
fnp-4899	59	10	of	of	ADP
fnp-4899	59	11	participants	participant	NOUN
fnp-4899	59	12	had	have	VERB
fnp-4899	59	13	late	late	ADJ
fnp-4899	59	14	-	-	PUNCT
fnp-4899	59	15	nc	nc	PROPN
fnp-4899	59	16	that	that	PRON
fnp-4899	59	17	may	may	AUX
fnp-4899	59	18	be	be	AUX
fnp-4899	59	19	driven	drive	VERB
fnp-4899	59	20	by	by	ADP
fnp-4899	59	21	genetic	genetic	ADJ
fnp-4899	59	22	factors	factor	NOUN
fnp-4899	59	23	(	(	PUNCT
fnp-4899	59	24	e.g.	e.g.	ADV
fnp-4899	59	25	,	,	PUNCT
fnp-4899	59	26	apoe	apoe	ADJ
fnp-4899	59	27	genotype	genotype	NOUN
fnp-4899	59	28	)	)	PUNCT
fnp-4899	59	29	or	or	CCONJ
fnp-4899	59	30	other	other	ADJ
fnp-4899	59	31	factors	factor	NOUN
fnp-4899	59	32	.	.	PUNCT
fnp-4899	60	1	4	4	X
fnp-4899	60	2	.	.	X
fnp-4899	60	3	tdp-43	tdp-43	NOUN
fnp-4899	60	4	represses	repress	VERB
fnp-4899	60	5	cryptic	cryptic	ADJ
fnp-4899	60	6	exon	exon	NOUN
fnp-4899	60	7	inclusion	inclusion	NOUN
fnp-4899	60	8	in	in	ADP
fnp-4899	60	9	unc13a	unc13a	ADV
fnp-4899	60	10	most	most	ADJ
fnp-4899	60	11	amyotrophic	amyotrophic	ADJ
fnp-4899	60	12	lateral	lateral	ADJ
fnp-4899	60	13	sclerosis	sclerosis	NOUN
fnp-4899	60	14	(	(	PUNCT
fnp-4899	60	15	als	als	NOUN
fnp-4899	60	16	)	)	PUNCT
fnp-4899	60	17	and	and	CCONJ
fnp-4899	60	18	a	a	DET
fnp-4899	60	19	subset	subset	NOUN
fnp-4899	60	20	of	of	ADP
fnp-4899	60	21	frontotemporal	frontotemporal	ADJ
fnp-4899	60	22	lobar	lobar	ADJ
fnp-4899	60	23	degeneration	degeneration	NOUN
fnp-4899	60	24	cases	case	NOUN
fnp-4899	60	25	display	display	VERB
fnp-4899	60	26	tar	tar	NOUN
fnp-4899	60	27	dna	dna	NOUN
fnp-4899	60	28	-	-	PUNCT
fnp-4899	60	29	binding	bind	VERB
fnp-4899	60	30	protein	protein	NOUN
fnp-4899	60	31	43	43	NUM
fnp-4899	60	32	(	(	PUNCT
fnp-4899	60	33	tdp-43	tdp-43	NOUN
fnp-4899	60	34	)	)	PUNCT
fnp-4899	60	35	pathology	pathology	NOUN
fnp-4899	60	36	.	.	PUNCT
fnp-4899	61	1	this	this	PRON
fnp-4899	61	2	is	be	AUX
fnp-4899	61	3	neuropathologically	neuropathologically	ADV
fnp-4899	61	4	reflected	reflect	VERB
fnp-4899	61	5	by	by	ADP
fnp-4899	61	6	translocation	translocation	NOUN
fnp-4899	61	7	of	of	ADP
fnp-4899	61	8	phosphorylated	phosphorylate	VERB
fnp-4899	61	9	forms	form	NOUN
fnp-4899	61	10	of	of	ADP
fnp-4899	61	11	the	the	DET
fnp-4899	61	12	protein	protein	NOUN
fnp-4899	61	13	from	from	ADP
fnp-4899	61	14	the	the	DET
fnp-4899	61	15	nucleus	nucleus	NOUN
fnp-4899	61	16	to	to	ADP
fnp-4899	61	17	the	the	DET
fnp-4899	61	18	cytoplasm	cytoplasm	NOUN
fnp-4899	61	19	,	,	PUNCT
fnp-4899	61	20	a	a	DET
fnp-4899	61	21	phenomenon	phenomenon	NOUN
fnp-4899	61	22	that	that	PRON
fnp-4899	61	23	is	be	AUX
fnp-4899	61	24	readily	readily	ADV
fnp-4899	61	25	visible	visible	ADJ
fnp-4899	61	26	on	on	ADP
fnp-4899	61	27	immunohistochemical	immunohistochemical	ADJ
fnp-4899	61	28	stains	stain	NOUN
fnp-4899	61	29	.	.	PUNCT
fnp-4899	62	1	the	the	DET
fnp-4899	62	2	significance	significance	NOUN
fnp-4899	62	3	and	and	CCONJ
fnp-4899	62	4	functional	functional	ADJ
fnp-4899	62	5	implications	implication	NOUN
fnp-4899	62	6	of	of	ADP
fnp-4899	62	7	this	this	DET
fnp-4899	62	8	translocation	translocation	NOUN
fnp-4899	62	9	are	be	AUX
fnp-4899	62	10	not	not	PART
fnp-4899	62	11	clear	clear	ADJ
fnp-4899	62	12	,	,	PUNCT
fnp-4899	62	13	but	but	CCONJ
fnp-4899	62	14	may	may	AUX
fnp-4899	62	15	result	result	VERB
fnp-4899	62	16	in	in	ADP
fnp-4899	62	17	loss	loss	NOUN
fnp-4899	62	18	of	of	ADP
fnp-4899	62	19	tdp-43	tdp-43	NOUN
fnp-4899	62	20	function	function	NOUN
fnp-4899	62	21	in	in	ADP
fnp-4899	62	22	the	the	DET
fnp-4899	62	23	nucleus	nucleus	NOUN
fnp-4899	62	24	.	.	PUNCT
fnp-4899	63	1	tdp-43	tdp-43	PROPN
fnp-4899	63	2	is	be	AUX
fnp-4899	63	3	an	an	DET
fnp-4899	63	4	rna	rna	NOUN
fnp-4899	63	5	-	-	PUNCT
fnp-4899	63	6	binding	bind	VERB
fnp-4899	63	7	protein	protein	NOUN
fnp-4899	63	8	with	with	ADP
fnp-4899	63	9	numerous	numerous	ADJ
fnp-4899	63	10	roles	role	NOUN
fnp-4899	63	11	,	,	PUNCT
fnp-4899	63	12	including	include	VERB
fnp-4899	63	13	repression	repression	NOUN
fnp-4899	63	14	of	of	ADP
fnp-4899	63	15	the	the	DET
fnp-4899	63	16	inclusion	inclusion	NOUN
fnp-4899	63	17	of	of	ADP
fnp-4899	63	18	cryptic	cryptic	ADJ
fnp-4899	63	19	exons	exon	NOUN
fnp-4899	63	20	during	during	ADP
fnp-4899	63	21	splicing	splicing	NOUN
fnp-4899	63	22	of	of	ADP
fnp-4899	63	23	heterogeneous	heterogeneous	ADJ
fnp-4899	63	24	rna	rna	NOUN
fnp-4899	63	25	while	while	SCONJ
fnp-4899	63	26	in	in	ADP
fnp-4899	63	27	the	the	DET
fnp-4899	63	28	nucleus	nucleus	NOUN
fnp-4899	63	29	.	.	PUNCT
fnp-4899	64	1	previous	previous	ADJ
fnp-4899	64	2	studies	study	NOUN
fnp-4899	64	3	have	have	AUX
fnp-4899	64	4	highlighted	highlight	VERB
fnp-4899	64	5	several	several	ADJ
fnp-4899	64	6	genes	gene	NOUN
fnp-4899	64	7	,	,	PUNCT
fnp-4899	64	8	including	include	VERB
fnp-4899	64	9	poldip3	poldip3	NOUN
fnp-4899	64	10	and	and	CCONJ
fnp-4899	64	11	stmn2	stmn2	ADJ
fnp-4899	64	12	that	that	PRON
fnp-4899	64	13	exhibit	exhibit	VERB
fnp-4899	64	14	aberrant	aberrant	ADJ
fnp-4899	64	15	splicing	splicing	NOUN
fnp-4899	64	16	following	follow	VERB
fnp-4899	64	17	tdp-43	tdp-43	PROPN
fnp-4899	64	18	depletion	depletion	NOUN
fnp-4899	64	19	.	.	PUNCT
fnp-4899	65	1	in	in	ADP
fnp-4899	65	2	a	a	DET
fnp-4899	65	3	paper	paper	NOUN
fnp-4899	65	4	by	by	ADP
fnp-4899	65	5	ma	ma	PROPN
fnp-4899	65	6	et	et	PROPN
fnp-4899	65	7	al	al	PROPN
fnp-4899	65	8	.	.	PROPN
fnp-4899	65	9	,	,	PUNCT
fnp-4899	65	10	investigators	investigator	NOUN
fnp-4899	65	11	sought	seek	VERB
fnp-4899	65	12	to	to	PART
fnp-4899	65	13	identify	identify	VERB
fnp-4899	65	14	additional	additional	ADJ
fnp-4899	65	15	genes	gene	NOUN
fnp-4899	65	16	that	that	PRON
fnp-4899	65	17	exhibit	exhibit	VERB
fnp-4899	65	18	cryptic	cryptic	ADJ
fnp-4899	65	19	splicing	splicing	NOUN
fnp-4899	65	20	changes	change	NOUN
fnp-4899	65	21	that	that	PRON
fnp-4899	65	22	are	be	AUX
fnp-4899	65	23	regulated	regulate	VERB
fnp-4899	65	24	by	by	ADP
fnp-4899	65	25	tdp-43	tdp-43	PROPN
fnp-4899	65	26	(	(	PUNCT
fnp-4899	65	27	ma	ma	PROPN
fnp-4899	65	28	et	et	PROPN
fnp-4899	65	29	al	al	PROPN
fnp-4899	65	30	.	.	PROPN
fnp-4899	65	31	,	,	PUNCT
fnp-4899	65	32	2022	2022	NUM
fnp-4899	65	33	)	)	PUNCT
fnp-4899	65	34	.	.	PUNCT
fnp-4899	66	1	using	use	VERB
fnp-4899	66	2	post	post	ADJ
fnp-4899	66	3	-	-	ADJ
fnp-4899	66	4	mortem	mortem	ADJ
fnp-4899	66	5	brain	brain	NOUN
fnp-4899	66	6	tissues	tissue	NOUN
fnp-4899	66	7	from	from	ADP
fnp-4899	66	8	patients	patient	NOUN
fnp-4899	66	9	with	with	ADP
fnp-4899	66	10	frontotemporal	frontotemporal	ADJ
fnp-4899	66	11	lobar	lobar	ADJ
fnp-4899	66	12	degeneration	degeneration	NOUN
fnp-4899	66	13	(	(	PUNCT
fnp-4899	66	14	ftld	ftld	ADJ
fnp-4899	66	15	)	)	PUNCT
fnp-4899	66	16	and	and	CCONJ
fnp-4899	66	17	als	al	NOUN
fnp-4899	66	18	,	,	PUNCT
fnp-4899	66	19	the	the	DET
fnp-4899	66	20	authors	author	NOUN
fnp-4899	66	21	used	use	VERB
fnp-4899	66	22	fluorescence	fluorescence	ADJ
fnp-4899	66	23	-	-	PUNCT
fnp-4899	66	24	activated	activate	VERB
fnp-4899	66	25	cell	cell	NOUN
fnp-4899	66	26	sorting	sort	VERB
fnp-4899	66	27	to	to	PART
fnp-4899	66	28	isolate	isolate	VERB
fnp-4899	66	29	nuclei	nucleus	NOUN
fnp-4899	66	30	with	with	ADP
fnp-4899	66	31	nuclear	nuclear	ADJ
fnp-4899	66	32	tdp-43	tdp-43	NOUN
fnp-4899	66	33	protein	protein	NOUN
fnp-4899	66	34	expression	expression	NOUN
fnp-4899	66	35	from	from	ADP
fnp-4899	66	36	nuclei	nucleus	NOUN
fnp-4899	66	37	lacking	lack	VERB
fnp-4899	66	38	tdp-43	tdp-43	PROPN
fnp-4899	66	39	and	and	CCONJ
fnp-4899	66	40	performed	perform	VERB
fnp-4899	66	41	rna	rna	PROPN
fnp-4899	66	42	-	-	PUNCT
fnp-4899	66	43	seq	seq	NOUN
fnp-4899	66	44	.	.	PUNCT
fnp-4899	67	1	they	they	PRON
fnp-4899	67	2	found	find	VERB
fnp-4899	67	3	66	66	NUM
fnp-4899	67	4	genes	gene	NOUN
fnp-4899	67	5	with	with	ADP
fnp-4899	67	6	altered	altered	ADJ
fnp-4899	67	7	splicing	splicing	NOUN
fnp-4899	67	8	using	use	VERB
fnp-4899	67	9	this	this	DET
fnp-4899	67	10	analysis	analysis	NOUN
fnp-4899	67	11	,	,	PUNCT
fnp-4899	67	12	including	include	VERB
fnp-4899	67	13	unc13a	unc13a	NOUN
fnp-4899	67	14	,	,	PUNCT
fnp-4899	67	15	which	which	PRON
fnp-4899	67	16	had	have	AUX
fnp-4899	67	17	previously	previously	ADV
fnp-4899	67	18	been	be	AUX
fnp-4899	67	19	identified	identify	VERB
fnp-4899	67	20	in	in	ADP
fnp-4899	67	21	genome	genome	NOUN
fnp-4899	67	22	wide	wide	ADJ
fnp-4899	67	23	association	association	NOUN
fnp-4899	67	24	studies	study	NOUN
fnp-4899	67	25	with	with	ADP
fnp-4899	67	26	unclear	unclear	ADJ
fnp-4899	67	27	mechanisms	mechanism	NOUN
fnp-4899	67	28	of	of	ADP
fnp-4899	67	29	increased	increase	VERB
fnp-4899	67	30	risk	risk	NOUN
fnp-4899	67	31	.	.	PUNCT
fnp-4899	68	1	specifically	specifically	ADV
fnp-4899	68	2	,	,	PUNCT
fnp-4899	68	3	they	they	PRON
fnp-4899	68	4	found	find	VERB
fnp-4899	68	5	a	a	DET
fnp-4899	68	6	cryptic	cryptic	ADJ
fnp-4899	68	7	exon	exon	NOUN
fnp-4899	68	8	that	that	PRON
fnp-4899	68	9	is	be	AUX
fnp-4899	68	10	retained	retain	VERB
fnp-4899	68	11	in	in	ADP
fnp-4899	68	12	cells	cell	NOUN
fnp-4899	68	13	with	with	ADP
fnp-4899	68	14	tdp-43	tdp-43	PROPN
fnp-4899	68	15	pathology	pathology	NOUN
fnp-4899	68	16	that	that	PRON
fnp-4899	68	17	could	could	AUX
fnp-4899	68	18	be	be	AUX
fnp-4899	68	19	detected	detect	VERB
fnp-4899	68	20	with	with	ADP
fnp-4899	68	21	exon	exon	NOUN
fnp-4899	68	22	splice	splice	NOUN
fnp-4899	68	23	site	site	NOUN
fnp-4899	68	24	specific	specific	ADJ
fnp-4899	68	25	probes	probe	NOUN
fnp-4899	68	26	(	(	PUNCT
fnp-4899	68	27	figure	figure	NOUN
fnp-4899	68	28	4	4	NUM
fnp-4899	68	29	)	)	PUNCT
fnp-4899	68	30	.	.	PUNCT
fnp-4899	69	1	further	far	ADV
fnp-4899	69	2	cellular	cellular	ADJ
fnp-4899	69	3	and	and	CCONJ
fnp-4899	69	4	histological	histological	ADJ
fnp-4899	69	5	validation	validation	NOUN
fnp-4899	69	6	supported	support	VERB
fnp-4899	69	7	these	these	DET
fnp-4899	69	8	findings	finding	NOUN
fnp-4899	69	9	.	.	PUNCT
fnp-4899	70	1	it	it	PRON
fnp-4899	70	2	is	be	AUX
fnp-4899	70	3	known	know	VERB
fnp-4899	70	4	from	from	ADP
fnp-4899	70	5	studies	study	NOUN
fnp-4899	70	6	in	in	ADP
fnp-4899	70	7	c.	c.	PROPN
fnp-4899	70	8	elegans	elegan	NOUN
fnp-4899	70	9	and	and	CCONJ
fnp-4899	70	10	other	other	ADJ
fnp-4899	70	11	systems	system	NOUN
fnp-4899	70	12	that	that	PRON
fnp-4899	70	13	unc13a	unc13a	ADV
fnp-4899	70	14	encodes	encode	VERB
fnp-4899	70	15	for	for	ADP
fnp-4899	70	16	a	a	DET
fnp-4899	70	17	synaptic	synaptic	ADJ
fnp-4899	70	18	multidomain	multidomain	NOUN
fnp-4899	70	19	protein	protein	NOUN
fnp-4899	70	20	that	that	PRON
fnp-4899	70	21	participates	participate	VERB
fnp-4899	70	22	in	in	ADP
fnp-4899	70	23	vesicle	vesicle	NOUN
fnp-4899	70	24	priming	priming	NOUN
fnp-4899	70	25	prior	prior	ADV
fnp-4899	70	26	to	to	ADP
fnp-4899	70	27	fusion	fusion	NOUN
fnp-4899	70	28	.	.	PUNCT
fnp-4899	71	1	these	these	DET
fnp-4899	71	2	findings	finding	NOUN
fnp-4899	71	3	provide	provide	VERB
fnp-4899	71	4	a	a	DET
fnp-4899	71	5	direct	direct	ADJ
fnp-4899	71	6	mechanistic	mechanistic	ADJ
fnp-4899	71	7	link	link	NOUN
fnp-4899	71	8	between	between	ADP
fnp-4899	71	9	loss	loss	NOUN
fnp-4899	71	10	of	of	ADP
fnp-4899	71	11	tdp-43	tdp-43	NOUN
fnp-4899	71	12	function	function	NOUN
fnp-4899	71	13	and	and	CCONJ
fnp-4899	71	14	a	a	DET
fnp-4899	71	15	strong	strong	ADJ
fnp-4899	71	16	genetic	genetic	ADJ
fnp-4899	71	17	risk	risk	NOUN
fnp-4899	71	18	factor	factor	NOUN
fnp-4899	71	19	for	for	ADP
fnp-4899	71	20	als	al	NOUN
fnp-4899	71	21	-	-	PUNCT
fnp-4899	71	22	ftd	ftd	NOUN
fnp-4899	71	23	.	.	PUNCT
fnp-4899	72	1	figure	figure	NOUN
fnp-4899	72	2	4	4	NUM
fnp-4899	72	3	.	.	X
fnp-4899	73	1	unc13a	unc13a	PUNCT
fnp-4899	73	2	cryptic	cryptic	ADJ
fnp-4899	73	3	splicing	splicing	NOUN
fnp-4899	73	4	is	be	AUX
fnp-4899	73	5	associated	associate	VERB
fnp-4899	73	6	with	with	ADP
fnp-4899	73	7	loss	loss	NOUN
fnp-4899	73	8	of	of	ADP
fnp-4899	73	9	nuclear	nuclear	ADJ
fnp-4899	73	10	tdp-43	tdp-43	NOUN
fnp-4899	73	11	in	in	ADP
fnp-4899	73	12	patients	patient	NOUN
fnp-4899	73	13	with	with	ADP
fnp-4899	73	14	ftd	ftd	PROPN
fnp-4899	73	15	and	and	CCONJ
fnp-4899	73	16	motor	motor	PROPN
fnp-4899	73	17	neuron	neuron	PROPN
fnp-4899	73	18	disease	disease	PROPN
fnp-4899	73	19	.	.	PUNCT
fnp-4899	74	1	a.	a.	NOUN
fnp-4899	74	2	basescope	basescope	PROPN
fnp-4899	74	3	probe	probe	PROPN
fnp-4899	74	4	design	design	PROPN
fnp-4899	74	5	b.	b.	PROPN
fnp-4899	74	6	in	in	ADP
fnp-4899	74	7	situ	situ	ADJ
fnp-4899	74	8	hybridization	hybridization	NOUN
fnp-4899	74	9	using	use	VERB
fnp-4899	74	10	the	the	DET
fnp-4899	74	11	unc13a	unc13a	NUM
fnp-4899	74	12	e20	e20	NOUN
fnp-4899	74	13	/	/	SYM
fnp-4899	74	14	ce	ce	PROPN
fnp-4899	74	15	probe	probe	NOUN
fnp-4899	74	16	,	,	PUNCT
fnp-4899	74	17	combined	combine	VERB
fnp-4899	74	18	with	with	ADP
fnp-4899	74	19	immunofluorescence	immunofluorescence	NOUN
fnp-4899	74	20	for	for	ADP
fnp-4899	74	21	tdp-43	tdp-43	NOUN
fnp-4899	74	22	and	and	CCONJ
fnp-4899	74	23	neun	neun	NOUN
fnp-4899	74	24	illustrating	illustrate	VERB
fnp-4899	74	25	the	the	DET
fnp-4899	74	26	presence	presence	NOUN
fnp-4899	74	27	of	of	ADP
fnp-4899	74	28	unc13a	unc13a	PROPN
fnp-4899	74	29	ce	ce	PROPN
fnp-4899	74	30	(	(	PUNCT
fnp-4899	74	31	arrowheads	arrowhead	NOUN
fnp-4899	74	32	)	)	PUNCT
fnp-4899	74	33	in	in	ADP
fnp-4899	74	34	neurons	neuron	NOUN
fnp-4899	74	35	showing	show	VERB
fnp-4899	74	36	depletion	depletion	NOUN
fnp-4899	74	37	of	of	ADP
fnp-4899	74	38	nuclear	nuclear	ADJ
fnp-4899	74	39	tdp-43	tdp-43	PROPN
fnp-4899	74	40	.	.	PUNCT
fnp-4899	75	1	scale	scale	NOUN
fnp-4899	75	2	bar	bar	NOUN
fnp-4899	75	3	,	,	PUNCT
fnp-4899	75	4	10	10	NUM
fnp-4899	75	5	μm	μm	NOUN
fnp-4899	75	6	.	.	PUNCT
fnp-4899	76	1	(	(	PUNCT
fnp-4899	76	2	reproduced	reproduce	VERB
fnp-4899	76	3	from	from	ADP
fnp-4899	76	4	ma	ma	PROPN
fnp-4899	76	5	et	et	PROPN
fnp-4899	76	6	al	al	PROPN
fnp-4899	76	7	.	.	PROPN
fnp-4899	76	8	,	,	PUNCT
fnp-4899	76	9	2022	2022	NUM
fnp-4899	76	10	under	under	ADP
fnp-4899	76	11	the	the	DET
fnp-4899	76	12	creative	creative	ADJ
fnp-4899	76	13	commons	common	NOUN
fnp-4899	76	14	license	license	NOUN
fnp-4899	76	15	)	)	PUNCT
fnp-4899	76	16	.	.	PUNCT
fnp-4899	77	1	5	5	X
fnp-4899	77	2	.	.	X
fnp-4899	77	3	a	a	DET
fnp-4899	77	4	surprising	surprising	ADJ
fnp-4899	77	5	turn	turn	NOUN
fnp-4899	77	6	in	in	ADP
fnp-4899	77	7	frontotemporal	frontotemporal	ADJ
fnp-4899	77	8	dementia	dementia	NOUN
fnp-4899	77	9	ftld	ftld	NOUN
fnp-4899	77	10	is	be	AUX
fnp-4899	77	11	the	the	DET
fnp-4899	77	12	third	third	ADJ
fnp-4899	77	13	most	most	ADV
fnp-4899	77	14	common	common	ADJ
fnp-4899	77	15	neurodegenerative	neurodegenerative	ADJ
fnp-4899	77	16	disorder	disorder	NOUN
fnp-4899	77	17	after	after	ADP
fnp-4899	77	18	alzheimer	alzheimer	PROPN
fnp-4899	77	19	’s	’s	PART
fnp-4899	77	20	and	and	CCONJ
fnp-4899	77	21	parkinson	parkinson	NOUN
fnp-4899	77	22	’s	’s	PART
fnp-4899	77	23	disease	disease	NOUN
fnp-4899	77	24	,	,	PUNCT
fnp-4899	77	25	with	with	ADP
fnp-4899	77	26	one	one	NUM
fnp-4899	77	27	major	major	ADJ
fnp-4899	77	28	ftld	ftld	ADJ
fnp-4899	77	29	subtype	subtype	NOUN
fnp-4899	77	30	characterized	characterize	VERB
fnp-4899	77	31	by	by	ADP
fnp-4899	77	32	pathological	pathological	ADJ
fnp-4899	77	33	neuronal	neuronal	ADJ
fnp-4899	77	34	inclusions	inclusion	NOUN
fnp-4899	77	35	with	with	ADP
fnp-4899	77	36	tdp-43	tdp-43	PROPN
fnp-4899	77	37	immunoreactivity	immunoreactivity	PROPN
fnp-4899	77	38	.	.	PUNCT
fnp-4899	78	1	determining	determine	VERB
fnp-4899	78	2	the	the	DET
fnp-4899	78	3	atomic	atomic	ADJ
fnp-4899	78	4	structure	structure	NOUN
fnp-4899	78	5	of	of	ADP
fnp-4899	78	6	these	these	DET
fnp-4899	78	7	inclusions	inclusion	NOUN
fnp-4899	78	8	is	be	AUX
fnp-4899	78	9	a	a	DET
fnp-4899	78	10	high	high	ADJ
fnp-4899	78	11	research	research	NOUN
fnp-4899	78	12	priority	priority	NOUN
fnp-4899	78	13	given	give	VERB
fnp-4899	78	14	the	the	DET
fnp-4899	78	15	expected	expect	VERB
fnp-4899	78	16	utility	utility	NOUN
fnp-4899	78	17	for	for	ADP
fnp-4899	78	18	facilitating	facilitate	VERB
fnp-4899	78	19	biomarker	biomarker	NOUN
fnp-4899	78	20	and	and	CCONJ
fnp-4899	78	21	therapeutic	therapeutic	ADJ
fnp-4899	78	22	discovery	discovery	NOUN
fnp-4899	78	23	.	.	PUNCT
fnp-4899	79	1	using	use	VERB
fnp-4899	79	2	cryogenic	cryogenic	NOUN
fnp-4899	79	3	electron	electron	NOUN
fnp-4899	79	4	microscopy	microscopy	NOUN
fnp-4899	79	5	(	(	PUNCT
fnp-4899	79	6	cryo	cryo	NOUN
fnp-4899	79	7	-	-	PUNCT
fnp-4899	79	8	em	em	PROPN
fnp-4899	79	9	)	)	PUNCT
fnp-4899	79	10	,	,	PUNCT
fnp-4899	79	11	three	three	NUM
fnp-4899	79	12	independent	independent	ADJ
fnp-4899	79	13	groups	group	NOUN
fnp-4899	79	14	addressed	address	VERB
fnp-4899	79	15	this	this	DET
fnp-4899	79	16	gap	gap	NOUN
fnp-4899	79	17	in	in	ADP
fnp-4899	79	18	knowledge	knowledge	NOUN
fnp-4899	79	19	with	with	ADP
fnp-4899	79	20	all	all	PRON
fnp-4899	79	21	making	make	VERB
fnp-4899	79	22	an	an	DET
fnp-4899	79	23	astonishing	astonishing	ADJ
fnp-4899	79	24	discovery	discovery	NOUN
fnp-4899	79	25	:	:	PUNCT
fnp-4899	79	26	the	the	DET
fnp-4899	79	27	extracted	extract	VERB
fnp-4899	79	28	amyloid	amyloid	NOUN
fnp-4899	79	29	fibrils	fibril	NOUN
fnp-4899	79	30	were	be	AUX
fnp-4899	79	31	composed	compose	VERB
fnp-4899	79	32	of	of	ADP
fnp-4899	79	33	fragments	fragment	NOUN
fnp-4899	79	34	of	of	ADP
fnp-4899	79	35	transmembrane	transmembrane	ADJ
fnp-4899	79	36	protein	protein	NOUN
fnp-4899	79	37	106b	106b	NOUN
fnp-4899	79	38	(	(	PUNCT
fnp-4899	79	39	tmem106b	tmem106b	PROPN
fnp-4899	79	40	)	)	PUNCT
fnp-4899	79	41	,	,	PUNCT
fnp-4899	79	42	a	a	DET
fnp-4899	79	43	lysosomal	lysosomal	ADJ
fnp-4899	79	44	membrane	membrane	NOUN
fnp-4899	79	45	protein	protein	NOUN
fnp-4899	79	46	previously	previously	ADV
fnp-4899	79	47	implicated	implicate	VERB
fnp-4899	79	48	as	as	ADP
fnp-4899	79	49	a	a	DET
fnp-4899	79	50	genetic	genetic	ADJ
fnp-4899	79	51	risk	risk	NOUN
fnp-4899	79	52	factor	factor	NOUN
fnp-4899	79	53	for	for	ADP
fnp-4899	79	54	ftld	ftld	ADJ
fnp-4899	79	55	-	-	PUNCT
fnp-4899	79	56	tdp	tdp	NOUN
fnp-4899	79	57	(	(	PUNCT
fnp-4899	79	58	chang	chang	PROPN
fnp-4899	79	59	et	et	PROPN
fnp-4899	79	60	al	al	PROPN
fnp-4899	79	61	.	.	PROPN
fnp-4899	79	62	,	,	PUNCT
fnp-4899	79	63	2022	2022	NUM
fnp-4899	79	64	;	;	PUNCT
fnp-4899	80	1	jiang	jiang	PROPN
fnp-4899	80	2	et	et	PROPN
fnp-4899	80	3	al	al	PROPN
fnp-4899	80	4	.	.	PROPN
fnp-4899	80	5	,	,	PUNCT
fnp-4899	80	6	2022	2022	NUM
fnp-4899	80	7	;	;	PUNCT
fnp-4899	80	8	schweighauser	schweighauser	NOUN
fnp-4899	80	9	et	et	PROPN
fnp-4899	80	10	al	al	PROPN
fnp-4899	80	11	.	.	PROPN
fnp-4899	80	12	,	,	PUNCT
fnp-4899	80	13	2022	2022	NUM
fnp-4899	80	14	)	)	PUNCT
fnp-4899	80	15	.	.	PUNCT
fnp-4899	81	1	while	while	SCONJ
fnp-4899	81	2	details	detail	NOUN
fnp-4899	81	3	among	among	ADP
fnp-4899	81	4	the	the	DET
fnp-4899	81	5	studies	study	NOUN
fnp-4899	81	6	differ	differ	VERB
fnp-4899	81	7	,	,	PUNCT
fnp-4899	81	8	in	in	ADP
fnp-4899	81	9	essence	essence	NOUN
fnp-4899	81	10	the	the	DET
fnp-4899	81	11	inclusions	inclusion	NOUN
fnp-4899	81	12	consist	consist	VERB
fnp-4899	81	13	of	of	ADP
fnp-4899	81	14	a	a	DET
fnp-4899	81	15	normally	normally	ADV
fnp-4899	81	16	intraluminal	intraluminal	ADJ
fnp-4899	81	17	135	135	NUM
fnp-4899	81	18	-	-	PUNCT
fnp-4899	81	19	residue	residue	NOUN
fnp-4899	81	20	fragment	fragment	NOUN
fnp-4899	81	21	of	of	ADP
fnp-4899	81	22	tmem106b	tmem106b	PROPN
fnp-4899	81	23	that	that	PRON
fnp-4899	81	24	is	be	AUX
fnp-4899	81	25	likely	likely	ADV
fnp-4899	81	26	shed	shed	VERB
fnp-4899	81	27	before	before	ADP
fnp-4899	81	28	assuming	assume	VERB
fnp-4899	81	29	this	this	DET
fnp-4899	81	30	abnormal	abnormal	ADJ
fnp-4899	81	31	configuration	configuration	NOUN
fnp-4899	81	32	.	.	PUNCT
fnp-4899	82	1	the	the	DET
fnp-4899	82	2	aggregates	aggregate	NOUN
fnp-4899	82	3	,	,	PUNCT
fnp-4899	82	4	which	which	PRON
fnp-4899	82	5	are	be	AUX
fnp-4899	82	6	derived	derive	VERB
fnp-4899	82	7	from	from	ADP
fnp-4899	82	8	the	the	DET
fnp-4899	82	9	c	c	NOUN
fnp-4899	82	10	-	-	PUNCT
fnp-4899	82	11	terminus	terminus	NOUN
fnp-4899	82	12	,	,	PUNCT
fnp-4899	82	13	were	be	AUX
fnp-4899	82	14	likely	likely	ADV
fnp-4899	82	15	missed	miss	VERB
fnp-4899	82	16	in	in	ADP
fnp-4899	82	17	previous	previous	ADJ
fnp-4899	82	18	studies	study	NOUN
fnp-4899	82	19	because	because	SCONJ
fnp-4899	82	20	most	most	ADJ
fnp-4899	82	21	antisera	antisera	NOUN
fnp-4899	82	22	target	target	VERB
fnp-4899	82	23	the	the	DET
fnp-4899	82	24	n	n	NOUN
fnp-4899	82	25	-	-	PUNCT
fnp-4899	82	26	terminus	terminus	NOUN
fnp-4899	82	27	of	of	ADP
fnp-4899	82	28	the	the	DET
fnp-4899	82	29	molecule	molecule	NOUN
fnp-4899	82	30	.	.	PUNCT
fnp-4899	83	1	these	these	DET
fnp-4899	83	2	findings	finding	NOUN
fnp-4899	83	3	raise	raise	VERB
fnp-4899	83	4	a	a	DET
fnp-4899	83	5	flood	flood	NOUN
fnp-4899	83	6	of	of	ADP
fnp-4899	83	7	new	new	ADJ
fnp-4899	83	8	questions	question	NOUN
fnp-4899	83	9	about	about	ADP
fnp-4899	83	10	tmem106b	tmem106b	ADJ
fnp-4899	83	11	and	and	CCONJ
fnp-4899	83	12	abnormal	abnormal	ADJ
fnp-4899	83	13	lysosomal	lysosomal	ADJ
fnp-4899	83	14	activity	activity	NOUN
fnp-4899	83	15	in	in	ADP
fnp-4899	83	16	neurodegeneration	neurodegeneration	NOUN
fnp-4899	83	17	.	.	PUNCT
fnp-4899	84	1	figure	figure	NOUN
fnp-4899	84	2	5	5	NUM
fnp-4899	84	3	.	.	PUNCT
fnp-4899	85	1	tmem106b	tmem106b	ADJ
fnp-4899	85	2	cryo	cryo	PROPN
fnp-4899	85	3	-	-	PUNCT
fnp-4899	85	4	em	em	PROPN
fnp-4899	85	5	doublet	doublet	PROPN
fnp-4899	85	6	fibril	fibril	PROPN
fnp-4899	85	7	.	.	PUNCT
fnp-4899	86	1	(	(	PUNCT
fnp-4899	86	2	reproduced	reproduce	VERB
fnp-4899	86	3	with	with	ADP
fnp-4899	86	4	permission	permission	NOUN
fnp-4899	86	5	from	from	ADP
fnp-4899	86	6	chang	chang	PROPN
fnp-4899	86	7	et	et	PROPN
fnp-4899	86	8	al	al	PROPN
fnp-4899	86	9	.	.	PROPN
fnp-4899	86	10	,	,	PUNCT
fnp-4899	86	11	2022	2022	NUM
fnp-4899	86	12	under	under	ADP
fnp-4899	86	13	the	the	DET
fnp-4899	86	14	creative	creative	ADJ
fnp-4899	86	15	commons	common	NOUN
fnp-4899	86	16	license	license	NOUN
fnp-4899	86	17	)	)	PUNCT
fnp-4899	86	18	.	.	PUNCT
fnp-4899	87	1	6	6	X
fnp-4899	87	2	.	.	X
fnp-4899	88	1	the	the	DET
fnp-4899	88	2	cryo	cryo	PROPN
fnp-4899	88	3	-	-	PUNCT
fnp-4899	88	4	em	em	PROPN
fnp-4899	88	5	structure	structure	NOUN
fnp-4899	88	6	of	of	ADP
fnp-4899	88	7	prion	prion	NOUN
fnp-4899	88	8	protein	protein	NOUN
fnp-4899	88	9	amyloid	amyloid	NOUN
fnp-4899	88	10	there	there	PRON
fnp-4899	88	11	are	be	VERB
fnp-4899	88	12	a	a	DET
fnp-4899	88	13	number	number	NOUN
fnp-4899	88	14	of	of	ADP
fnp-4899	88	15	dominantly	dominantly	ADV
fnp-4899	88	16	inherited	inherit	VERB
fnp-4899	88	17	prion	prion	NOUN
fnp-4899	88	18	protein	protein	NOUN
fnp-4899	88	19	(	(	PUNCT
fnp-4899	88	20	prp	prp	NOUN
fnp-4899	88	21	)	)	PUNCT
fnp-4899	88	22	amyloidoses	amyloidose	NOUN
fnp-4899	88	23	,	,	PUNCT
fnp-4899	88	24	including	include	VERB
fnp-4899	88	25	gerstmann	gerstmann	NOUN
fnp-4899	88	26	-	-	PUNCT
fnp-4899	88	27	sträussler	sträussler	NOUN
fnp-4899	88	28	-	-	PUNCT
fnp-4899	88	29	scheinker	scheinker	NOUN
fnp-4899	88	30	disease	disease	NOUN
fnp-4899	88	31	(	(	PUNCT
fnp-4899	88	32	gss	gss	PROPN
fnp-4899	88	33	)	)	PUNCT
fnp-4899	88	34	,	,	PUNCT
fnp-4899	88	35	prp	prp	PROPN
fnp-4899	88	36	cerebral	cerebral	ADJ
fnp-4899	88	37	amyloid	amyloid	NOUN
fnp-4899	88	38	angiopathy	angiopathy	NOUN
fnp-4899	88	39	,	,	PUNCT
fnp-4899	88	40	and	and	CCONJ
fnp-4899	88	41	prion	prion	NOUN
fnp-4899	88	42	amyloidosis	amyloidosis	NOUN
fnp-4899	88	43	with	with	ADP
fnp-4899	88	44	variable	variable	ADJ
fnp-4899	88	45	phenotypes	phenotype	NOUN
fnp-4899	88	46	.	.	PUNCT
fnp-4899	89	1	all	all	PRON
fnp-4899	89	2	are	be	AUX
fnp-4899	89	3	caused	cause	VERB
fnp-4899	89	4	by	by	ADP
fnp-4899	89	5	mutations	mutation	NOUN
fnp-4899	89	6	in	in	ADP
fnp-4899	89	7	the	the	DET
fnp-4899	89	8	prion	prion	NOUN
fnp-4899	89	9	protein	protein	NOUN
fnp-4899	89	10	gene	gene	NOUN
fnp-4899	89	11	(	(	PUNCT
fnp-4899	89	12	prnp	prnp	PROPN
fnp-4899	89	13	)	)	PUNCT
fnp-4899	89	14	.	.	PUNCT
fnp-4899	90	1	gss	gss	PROPN
fnp-4899	90	2	is	be	AUX
fnp-4899	90	3	notable	notable	ADJ
fnp-4899	90	4	in	in	ADP
fnp-4899	90	5	that	that	DET
fnp-4899	90	6	typical	typical	ADJ
fnp-4899	90	7	extracellular	extracellular	ADJ
fnp-4899	90	8	deposits	deposit	NOUN
fnp-4899	90	9	made	make	VERB
fnp-4899	90	10	of	of	ADP
fnp-4899	90	11	prp	prp	PROPN
fnp-4899	90	12	amyloid	amyloid	NOUN
fnp-4899	90	13	(	(	PUNCT
fnp-4899	90	14	aprp	aprp	NOUN
fnp-4899	90	15	)	)	PUNCT
fnp-4899	90	16	are	be	AUX
fnp-4899	90	17	associated	associate	VERB
fnp-4899	90	18	with	with	ADP
fnp-4899	90	19	abnormal	abnormal	ADJ
fnp-4899	90	20	intraneuronal	intraneuronal	ADJ
fnp-4899	90	21	tau	tau	PROPN
fnp-4899	90	22	inclusions	inclusion	NOUN
fnp-4899	90	23	that	that	PRON
fnp-4899	90	24	are	be	AUX
fnp-4899	90	25	identical	identical	ADJ
fnp-4899	90	26	to	to	ADP
fnp-4899	90	27	those	those	PRON
fnp-4899	90	28	observed	observe	VERB
fnp-4899	90	29	in	in	ADP
fnp-4899	90	30	classical	classical	ADJ
fnp-4899	90	31	ad	ad	NOUN
fnp-4899	90	32	,	,	PUNCT
fnp-4899	90	33	which	which	PRON
fnp-4899	90	34	raises	raise	VERB
fnp-4899	90	35	fundamental	fundamental	ADJ
fnp-4899	90	36	questions	question	NOUN
fnp-4899	90	37	as	as	ADP
fnp-4899	90	38	to	to	ADP
fnp-4899	90	39	how	how	SCONJ
fnp-4899	90	40	amyloid	amyloid	NOUN
fnp-4899	90	41	-	-	PUNCT
fnp-4899	90	42	beta	beta	NOUN
fnp-4899	90	43	causes	cause	VERB
fnp-4899	90	44	tau	tau	PROPN
fnp-4899	90	45	pathology	pathology	PROPN
fnp-4899	90	46	and	and	CCONJ
fnp-4899	90	47	whether	whether	SCONJ
fnp-4899	90	48	there	there	PRON
fnp-4899	90	49	are	be	VERB
fnp-4899	90	50	shared	share	VERB
fnp-4899	90	51	pathogenic	pathogenic	ADJ
fnp-4899	90	52	mechanisms	mechanism	NOUN
fnp-4899	90	53	.	.	PUNCT
fnp-4899	91	1	understanding	understand	VERB
fnp-4899	91	2	the	the	DET
fnp-4899	91	3	atomic	atomic	ADJ
fnp-4899	91	4	structure	structure	NOUN
fnp-4899	91	5	of	of	ADP
fnp-4899	91	6	the	the	DET
fnp-4899	91	7	aprp	aprp	NOUN
fnp-4899	91	8	has	have	VERB
fnp-4899	91	9	the	the	DET
fnp-4899	91	10	potential	potential	NOUN
fnp-4899	91	11	to	to	PART
fnp-4899	91	12	shed	shed	VERB
fnp-4899	91	13	light	light	NOUN
fnp-4899	91	14	on	on	ADP
fnp-4899	91	15	how	how	SCONJ
fnp-4899	91	16	extracellular	extracellular	ADJ
fnp-4899	91	17	amyloid	amyloid	NOUN
fnp-4899	91	18	deposition	deposition	NOUN
fnp-4899	91	19	in	in	ADP
fnp-4899	91	20	general	general	ADJ
fnp-4899	91	21	might	might	AUX
fnp-4899	91	22	trigger	trigger	VERB
fnp-4899	91	23	tau	tau	PROPN
fnp-4899	91	24	pathology	pathology	NOUN
fnp-4899	91	25	independently	independently	ADV
fnp-4899	91	26	and	and	CCONJ
fnp-4899	91	27	facilitate	facilitate	VERB
fnp-4899	91	28	the	the	DET
fnp-4899	91	29	development	development	NOUN
fnp-4899	91	30	of	of	ADP
fnp-4899	91	31	positron	positron	NOUN
fnp-4899	91	32	emission	emission	NOUN
fnp-4899	91	33	tomography	tomography	NOUN
fnp-4899	91	34	(	(	PUNCT
fnp-4899	91	35	pet	pet	NOUN
fnp-4899	91	36	)	)	PUNCT
fnp-4899	91	37	tracers	tracer	NOUN
fnp-4899	91	38	as	as	ADV
fnp-4899	91	39	well	well	ADV
fnp-4899	91	40	as	as	ADP
fnp-4899	91	41	therapeutic	therapeutic	ADJ
fnp-4899	91	42	interventions	intervention	NOUN
fnp-4899	91	43	for	for	ADP
fnp-4899	91	44	prion	prion	NOUN
fnp-4899	91	45	diseases	disease	NOUN
fnp-4899	91	46	.	.	PUNCT
fnp-4899	92	1	this	this	PRON
fnp-4899	92	2	is	be	AUX
fnp-4899	92	3	possible	possible	ADJ
fnp-4899	92	4	with	with	ADP
fnp-4899	92	5	cryo	cryo	NOUN
fnp-4899	92	6	-	-	PUNCT
fnp-4899	92	7	em	em	PROPN
fnp-4899	92	8	.	.	PUNCT
fnp-4899	93	1	in	in	ADP
fnp-4899	93	2	a	a	DET
fnp-4899	93	3	study	study	NOUN
fnp-4899	93	4	entitled	entitle	VERB
fnp-4899	93	5	“	"	PUNCT
fnp-4899	93	6	cryo	cryo	PROPN
fnp-4899	93	7	-	-	PUNCT
fnp-4899	93	8	em	em	PRON
fnp-4899	93	9	structures	structure	NOUN
fnp-4899	93	10	of	of	ADP
fnp-4899	93	11	prion	prion	NOUN
fnp-4899	93	12	protein	protein	NOUN
fnp-4899	93	13	filaments	filament	NOUN
fnp-4899	93	14	from	from	ADP
fnp-4899	93	15	gerstmann	gerstmann	NOUN
fnp-4899	93	16	-	-	PUNCT
fnp-4899	93	17	sträussler	sträussler	NOUN
fnp-4899	93	18	-	-	PUNCT
fnp-4899	93	19	scheinker	scheinker	NOUN
fnp-4899	93	20	disease	disease	NOUN
fnp-4899	93	21	”	"	PUNCT
fnp-4899	93	22	,	,	PUNCT
fnp-4899	93	23	investigators	investigator	NOUN
fnp-4899	93	24	studied	study	VERB
fnp-4899	93	25	brain	brain	NOUN
fnp-4899	93	26	fibrils	fibril	NOUN
fnp-4899	93	27	isolated	isolate	VERB
fnp-4899	93	28	from	from	ADP
fnp-4899	93	29	two	two	NUM
fnp-4899	93	30	patients	patient	NOUN
fnp-4899	93	31	with	with	ADP
fnp-4899	93	32	the	the	DET
fnp-4899	93	33	prnp	prnp	PROPN
fnp-4899	93	34	f198s	f198s	PROPN
fnp-4899	93	35	mutation	mutation	NOUN
fnp-4899	93	36	(	(	PUNCT
fnp-4899	93	37	hallinan	hallinan	NOUN
fnp-4899	93	38	et	et	PROPN
fnp-4899	93	39	al	al	PROPN
fnp-4899	93	40	.	.	PROPN
fnp-4899	93	41	,	,	PUNCT
fnp-4899	93	42	2022	2022	NUM
fnp-4899	93	43	)	)	PUNCT
fnp-4899	93	44	.	.	PUNCT
fnp-4899	94	1	one	one	NUM
fnp-4899	94	2	patient	patient	NOUN
fnp-4899	94	3	was	be	AUX
fnp-4899	94	4	homozygous	homozygous	ADJ
fnp-4899	94	5	(	(	PUNCT
fnp-4899	94	6	vv	vv	NOUN
fnp-4899	94	7	)	)	PUNCT
fnp-4899	94	8	and	and	CCONJ
fnp-4899	94	9	the	the	DET
fnp-4899	94	10	other	other	ADJ
fnp-4899	94	11	homozygous	homozygous	ADJ
fnp-4899	94	12	(	(	PUNCT
fnp-4899	94	13	vm	vm	NOUN
fnp-4899	94	14	)	)	PUNCT
fnp-4899	94	15	at	at	ADP
fnp-4899	94	16	codon	codon	NOUN
fnp-4899	94	17	129	129	NUM
fnp-4899	94	18	,	,	PUNCT
fnp-4899	94	19	which	which	PRON
fnp-4899	94	20	is	be	AUX
fnp-4899	94	21	known	know	VERB
fnp-4899	94	22	to	to	PART
fnp-4899	94	23	influence	influence	NOUN
fnp-4899	94	24	disease	disease	NOUN
fnp-4899	94	25	onset	onset	NOUN
fnp-4899	94	26	and	and	CCONJ
fnp-4899	94	27	progression	progression	NOUN
fnp-4899	94	28	,	,	PUNCT
fnp-4899	94	29	allowed	allow	VERB
fnp-4899	94	30	them	they	PRON
fnp-4899	94	31	to	to	PART
fnp-4899	94	32	compare	compare	VERB
fnp-4899	94	33	this	this	DET
fnp-4899	94	34	important	important	ADJ
fnp-4899	94	35	clinically	clinically	ADV
fnp-4899	94	36	relevant	relevant	ADJ
fnp-4899	94	37	difference	difference	NOUN
fnp-4899	94	38	.	.	PUNCT
fnp-4899	95	1	looking	look	VERB
fnp-4899	95	2	at	at	ADP
fnp-4899	95	3	the	the	DET
fnp-4899	95	4	first	first	ADJ
fnp-4899	95	5	vv	vv	ADP
fnp-4899	95	6	homozygous	homozygous	ADJ
fnp-4899	95	7	patient	patient	NOUN
fnp-4899	95	8	,	,	PUNCT
fnp-4899	95	9	they	they	PRON
fnp-4899	95	10	found	find	VERB
fnp-4899	95	11	that	that	SCONJ
fnp-4899	95	12	the	the	DET
fnp-4899	95	13	aprp	aprp	NOUN
fnp-4899	95	14	was	be	AUX
fnp-4899	95	15	polymorphic	polymorphic	ADJ
fnp-4899	95	16	,	,	PUNCT
fnp-4899	95	17	with	with	ADP
fnp-4899	95	18	mainly	mainly	ADV
fnp-4899	95	19	two	two	NUM
fnp-4899	95	20	,	,	PUNCT
fnp-4899	95	21	three	three	NUM
fnp-4899	95	22	or	or	CCONJ
fnp-4899	95	23	four	four	NUM
fnp-4899	95	24	intertwined	intertwine	VERB
fnp-4899	95	25	protofilaments	protofilament	NOUN
fnp-4899	95	26	(	(	PUNCT
fnp-4899	95	27	figure	figure	NOUN
fnp-4899	95	28	6	6	NUM
fnp-4899	95	29	)	)	PUNCT
fnp-4899	95	30	.	.	PUNCT
fnp-4899	96	1	the	the	DET
fnp-4899	96	2	structures	structure	NOUN
fnp-4899	96	3	better	well	ADV
fnp-4899	96	4	delineated	delineate	VERB
fnp-4899	96	5	the	the	DET
fnp-4899	96	6	location	location	NOUN
fnp-4899	96	7	of	of	ADP
fnp-4899	96	8	the	the	DET
fnp-4899	96	9	v	v	NOUN
fnp-4899	96	10	residue	residue	NOUN
fnp-4899	96	11	at	at	ADP
fnp-4899	96	12	codon	codon	NOUN
fnp-4899	96	13	129	129	NUM
fnp-4899	96	14	,	,	PUNCT
fnp-4899	96	15	which	which	PRON
fnp-4899	96	16	is	be	AUX
fnp-4899	96	17	buried	bury	VERB
fnp-4899	96	18	deep	deep	ADV
fnp-4899	96	19	in	in	ADP
fnp-4899	96	20	the	the	DET
fnp-4899	96	21	amyloid	amyloid	NOUN
fnp-4899	96	22	core	core	NOUN
fnp-4899	96	23	,	,	PUNCT
fnp-4899	96	24	protected	protect	VERB
fnp-4899	96	25	from	from	ADP
fnp-4899	96	26	solvent	solvent	ADJ
fnp-4899	96	27	exchange	exchange	NOUN
fnp-4899	96	28	and	and	CCONJ
fnp-4899	96	29	tightly	tightly	ADV
fnp-4899	96	30	packed	pack	VERB
fnp-4899	96	31	,	,	PUNCT
fnp-4899	96	32	suggesting	suggest	VERB
fnp-4899	96	33	that	that	DET
fnp-4899	96	34	substitution	substitution	NOUN
fnp-4899	96	35	with	with	ADP
fnp-4899	96	36	a	a	DET
fnp-4899	96	37	methionine	methionine	NOUN
fnp-4899	96	38	would	would	AUX
fnp-4899	96	39	affect	affect	VERB
fnp-4899	96	40	fibril	fibril	ADJ
fnp-4899	96	41	formation	formation	NOUN
fnp-4899	96	42	.	.	PUNCT
fnp-4899	97	1	these	these	DET
fnp-4899	97	2	new	new	ADJ
fnp-4899	97	3	structural	structural	ADJ
fnp-4899	97	4	data	data	NOUN
fnp-4899	97	5	human	human	ADJ
fnp-4899	97	6	brain	brain	NOUN
fnp-4899	97	7	aprp	aprp	NOUN
fnp-4899	97	8	filaments	filament	NOUN
fnp-4899	97	9	have	have	VERB
fnp-4899	97	10	the	the	DET
fnp-4899	97	11	potential	potential	NOUN
fnp-4899	97	12	to	to	PART
fnp-4899	97	13	open	open	VERB
fnp-4899	97	14	new	new	ADJ
fnp-4899	97	15	avenues	avenue	NOUN
fnp-4899	97	16	for	for	ADP
fnp-4899	97	17	diagnosis	diagnosis	NOUN
fnp-4899	97	18	and	and	CCONJ
fnp-4899	97	19	treatment	treatment	NOUN
fnp-4899	97	20	of	of	ADP
fnp-4899	97	21	prion	prion	NOUN
fnp-4899	97	22	disease	disease	NOUN
fnp-4899	97	23	.	.	PUNCT
fnp-4899	98	1	figure	figure	VERB
fnp-4899	98	2	6	6	NUM
fnp-4899	98	3	.	.	PUNCT
fnp-4899	99	1	analysis	analysis	NOUN
fnp-4899	99	2	of	of	ADP
fnp-4899	99	3	the	the	DET
fnp-4899	99	4	m	m	PROPN
fnp-4899	99	5	/	/	SYM
fnp-4899	99	6	v	v	PROPN
fnp-4899	99	7	129	129	NUM
fnp-4899	99	8	residue	residue	NOUN
fnp-4899	99	9	region	region	NOUN
fnp-4899	99	10	of	of	ADP
fnp-4899	99	11	prion	prion	NOUN
fnp-4899	99	12	protein	protein	NOUN
fnp-4899	99	13	amyloid	amyloid	NOUN
fnp-4899	99	14	(	(	PUNCT
fnp-4899	99	15	aprp	aprp	NOUN
fnp-4899	99	16	)	)	PUNCT
fnp-4899	99	17	.	.	PUNCT
fnp-4899	100	1	a	a	DET
fnp-4899	100	2	,	,	PUNCT
fnp-4899	100	3	b.	b.	PROPN
fnp-4899	100	4	atomic	atomic	ADJ
fnp-4899	100	5	models	model	NOUN
fnp-4899	100	6	from	from	ADP
fnp-4899	100	7	patient	patient	NOUN
fnp-4899	100	8	1	1	NUM
fnp-4899	100	9	and	and	CCONJ
fnp-4899	100	10	2	2	NUM
fnp-4899	100	11	.	.	PUNCT
fnp-4899	101	1	the	the	DET
fnp-4899	101	2	129	129	NUM
fnp-4899	101	3	v	v	NOUN
fnp-4899	101	4	residue	residue	NOUN
fnp-4899	101	5	(	(	PUNCT
fnp-4899	101	6	green	green	ADJ
fnp-4899	101	7	)	)	PUNCT
fnp-4899	101	8	is	be	AUX
fnp-4899	101	9	tightly	tightly	ADV
fnp-4899	101	10	packed	pack	VERB
fnp-4899	101	11	.	.	PUNCT
fnp-4899	102	1	c	c	X
fnp-4899	102	2	,	,	PUNCT
fnp-4899	102	3	d.	d.	PROPN
fnp-4899	102	4	this	this	PRON
fnp-4899	102	5	leaves	leave	VERB
fnp-4899	102	6	little	little	ADJ
fnp-4899	102	7	space	space	NOUN
fnp-4899	102	8	for	for	ADP
fnp-4899	102	9	the	the	DET
fnp-4899	102	10	larger	large	ADJ
fnp-4899	102	11	methionine	methionine	NOUN
fnp-4899	102	12	residue	residue	NOUN
fnp-4899	102	13	(	(	PUNCT
fnp-4899	102	14	reproduced	reproduce	VERB
fnp-4899	102	15	with	with	ADP
fnp-4899	102	16	permission	permission	NOUN
fnp-4899	102	17	under	under	ADP
fnp-4899	102	18	the	the	DET
fnp-4899	102	19	creative	creative	ADJ
fnp-4899	102	20	commons	common	NOUN
fnp-4899	102	21	license	license	NOUN
fnp-4899	102	22	from	from	ADP
fnp-4899	102	23	hallinan	hallinan	PROPN
fnp-4899	102	24	et	et	PROPN
fnp-4899	102	25	al	al	PROPN
fnp-4899	102	26	.	.	PROPN
fnp-4899	102	27	,	,	PUNCT
fnp-4899	102	28	2022	2022	NUM
fnp-4899	102	29	)	)	PUNCT
fnp-4899	102	30	.	.	PUNCT
fnp-4899	103	1	7	7	X
fnp-4899	103	2	.	.	X
fnp-4899	103	3	apoe	apoe	PROPN
fnp-4899	103	4	's	's	PART
fnp-4899	103	5	role	role	NOUN
fnp-4899	103	6	in	in	ADP
fnp-4899	103	7	chronic	chronic	ADJ
fnp-4899	103	8	traumatic	traumatic	ADJ
fnp-4899	103	9	encephalopathy	encephalopathy	ADJ
fnp-4899	103	10	chronic	chronic	ADJ
fnp-4899	103	11	traumatic	traumatic	ADJ
fnp-4899	103	12	encephalopathy	encephalopathy	NOUN
fnp-4899	103	13	(	(	PUNCT
fnp-4899	103	14	cte	cte	NOUN
fnp-4899	103	15	)	)	PUNCT
fnp-4899	103	16	results	result	NOUN
fnp-4899	103	17	from	from	ADP
fnp-4899	103	18	mild	mild	ADJ
fnp-4899	103	19	yet	yet	CCONJ
fnp-4899	103	20	repetitive	repetitive	ADJ
fnp-4899	103	21	traumatic	traumatic	ADJ
fnp-4899	103	22	brain	brain	NOUN
fnp-4899	103	23	injury	injury	NOUN
fnp-4899	103	24	that	that	PRON
fnp-4899	103	25	is	be	AUX
fnp-4899	103	26	often	often	ADV
fnp-4899	103	27	sustained	sustain	VERB
fnp-4899	103	28	during	during	ADP
fnp-4899	103	29	contact	contact	NOUN
fnp-4899	103	30	sports	sport	NOUN
fnp-4899	103	31	or	or	CCONJ
fnp-4899	103	32	in	in	ADP
fnp-4899	103	33	other	other	ADJ
fnp-4899	103	34	contexts	contexts	NOUN
fnp-4899	103	35	.	.	PUNCT
fnp-4899	104	1	while	while	SCONJ
fnp-4899	104	2	the	the	DET
fnp-4899	104	3	association	association	NOUN
fnp-4899	104	4	between	between	ADP
fnp-4899	104	5	this	this	DET
fnp-4899	104	6	exogenous	exogenous	ADJ
fnp-4899	104	7	risk	risk	NOUN
fnp-4899	104	8	factor	factor	NOUN
fnp-4899	104	9	and	and	CCONJ
fnp-4899	104	10	resultant	resultant	VERB
fnp-4899	104	11	tauopathy	tauopathy	NOUN
fnp-4899	104	12	and	and	CCONJ
fnp-4899	104	13	neurodegeneration	neurodegeneration	NOUN
fnp-4899	104	14	is	be	AUX
fnp-4899	104	15	well	well	ADV
fnp-4899	104	16	established	establish	VERB
fnp-4899	104	17	,	,	PUNCT
fnp-4899	104	18	not	not	PART
fnp-4899	104	19	all	all	DET
fnp-4899	104	20	participants	participant	NOUN
fnp-4899	104	21	in	in	ADP
fnp-4899	104	22	contact	contact	NOUN
fnp-4899	104	23	sports	sport	NOUN
fnp-4899	104	24	develop	develop	VERB
fnp-4899	104	25	cte	cte	PROPN
fnp-4899	104	26	.	.	PUNCT
fnp-4899	105	1	this	this	PRON
fnp-4899	105	2	suggests	suggest	VERB
fnp-4899	105	3	that	that	SCONJ
fnp-4899	105	4	other	other	ADJ
fnp-4899	105	5	factors	factor	NOUN
fnp-4899	105	6	,	,	PUNCT
fnp-4899	105	7	perhaps	perhaps	ADV
fnp-4899	105	8	genetic	genetic	ADJ
fnp-4899	105	9	,	,	PUNCT
fnp-4899	105	10	might	might	AUX
fnp-4899	105	11	play	play	VERB
fnp-4899	105	12	a	a	DET
fnp-4899	105	13	moderating	moderate	VERB
fnp-4899	105	14	role	role	NOUN
fnp-4899	105	15	.	.	PUNCT
fnp-4899	106	1	one	one	NUM
fnp-4899	106	2	gene	gene	NOUN
fnp-4899	106	3	that	that	PRON
fnp-4899	106	4	has	have	AUX
fnp-4899	106	5	been	be	AUX
fnp-4899	106	6	implicated	implicate	VERB
fnp-4899	106	7	is	be	AUX
fnp-4899	106	8	apoe	apoe	ADJ
fnp-4899	106	9	,	,	PUNCT
fnp-4899	106	10	which	which	PRON
fnp-4899	106	11	encodes	encode	VERB
fnp-4899	106	12	the	the	DET
fnp-4899	106	13	most	most	ADV
fnp-4899	106	14	abundant	abundant	ADJ
fnp-4899	106	15	cholesterol	cholesterol	NOUN
fnp-4899	106	16	transporter	transporter	NOUN
fnp-4899	106	17	in	in	ADP
fnp-4899	106	18	the	the	DET
fnp-4899	106	19	brain	brain	NOUN
fnp-4899	106	20	that	that	PRON
fnp-4899	106	21	is	be	AUX
fnp-4899	106	22	also	also	ADV
fnp-4899	106	23	the	the	DET
fnp-4899	106	24	strongest	strong	ADJ
fnp-4899	106	25	genetic	genetic	ADJ
fnp-4899	106	26	risk	risk	NOUN
fnp-4899	106	27	factor	factor	NOUN
fnp-4899	106	28	for	for	ADP
fnp-4899	106	29	sporadic	sporadic	ADJ
fnp-4899	106	30	ad	ad	NOUN
fnp-4899	106	31	.	.	PUNCT
fnp-4899	107	1	previous	previous	ADJ
fnp-4899	107	2	studies	study	NOUN
fnp-4899	107	3	have	have	AUX
fnp-4899	107	4	suggested	suggest	VERB
fnp-4899	107	5	that	that	SCONJ
fnp-4899	107	6	the	the	DET
fnp-4899	107	7	apoeε4	apoeε4	PROPN
fnp-4899	107	8	allele	allele	PROPN
fnp-4899	107	9	may	may	AUX
fnp-4899	107	10	confer	confer	VERB
fnp-4899	107	11	risk	risk	NOUN
fnp-4899	107	12	for	for	ADP
fnp-4899	107	13	a	a	DET
fnp-4899	107	14	poor	poor	ADJ
fnp-4899	107	15	outcome	outcome	NOUN
fnp-4899	107	16	following	follow	VERB
fnp-4899	107	17	tbi	tbi	PROPN
fnp-4899	107	18	,	,	PUNCT
fnp-4899	107	19	but	but	CCONJ
fnp-4899	107	20	the	the	DET
fnp-4899	107	21	risk	risk	NOUN
fnp-4899	107	22	for	for	ADP
fnp-4899	107	23	cte	cte	NOUN
fnp-4899	107	24	remains	remain	VERB
fnp-4899	107	25	unclear	unclear	ADJ
fnp-4899	107	26	.	.	PUNCT
fnp-4899	108	1	in	in	ADP
fnp-4899	108	2	a	a	DET
fnp-4899	108	3	study	study	NOUN
fnp-4899	108	4	by	by	ADP
fnp-4899	108	5	atherton	atherton	PROPN
fnp-4899	108	6	et	et	PROPN
fnp-4899	108	7	al	al	PROPN
fnp-4899	108	8	.	.	PROPN
fnp-4899	108	9	,	,	PUNCT
fnp-4899	108	10	investigators	investigator	NOUN
fnp-4899	108	11	performed	perform	VERB
fnp-4899	108	12	the	the	DET
fnp-4899	108	13	largest	large	ADJ
fnp-4899	108	14	study	study	NOUN
fnp-4899	108	15	to	to	ADP
fnp-4899	108	16	date	date	NOUN
fnp-4899	108	17	investigating	investigate	VERB
fnp-4899	108	18	the	the	DET
fnp-4899	108	19	potential	potential	ADJ
fnp-4899	108	20	association	association	NOUN
fnp-4899	108	21	between	between	ADP
fnp-4899	108	22	apoe	apoe	NOUN
fnp-4899	108	23	and	and	CCONJ
fnp-4899	108	24	cte	cte	PROPN
fnp-4899	108	25	(	(	PUNCT
fnp-4899	108	26	atherton	atherton	PROPN
fnp-4899	108	27	et	et	PROPN
fnp-4899	108	28	al	al	PROPN
fnp-4899	108	29	.	.	PROPN
fnp-4899	108	30	,	,	PUNCT
fnp-4899	108	31	2022	2022	NUM
fnp-4899	108	32	)	)	PUNCT
fnp-4899	108	33	.	.	PUNCT
fnp-4899	109	1	the	the	DET
fnp-4899	109	2	study	study	NOUN
fnp-4899	109	3	was	be	AUX
fnp-4899	109	4	a	a	DET
fnp-4899	109	5	cross	cross	ADJ
fnp-4899	109	6	sectional	sectional	PROPN
fnp-4899	109	7	association	association	NOUN
fnp-4899	109	8	analysis	analysis	NOUN
fnp-4899	109	9	of	of	ADP
fnp-4899	109	10	364	364	NUM
fnp-4899	109	11	brain	brain	NOUN
fnp-4899	109	12	donors	donor	NOUN
fnp-4899	109	13	with	with	ADP
fnp-4899	109	14	repetitive	repetitive	ADJ
fnp-4899	109	15	head	head	NOUN
fnp-4899	109	16	impacts	impact	VERB
fnp-4899	109	17	exposure	exposure	NOUN
fnp-4899	109	18	(	(	PUNCT
fnp-4899	109	19	i.e.	i.e.	X
fnp-4899	109	20	,	,	PUNCT
fnp-4899	109	21	contact	contact	NOUN
fnp-4899	109	22	sports	sport	NOUN
fnp-4899	109	23	or	or	CCONJ
fnp-4899	109	24	military	military	ADJ
fnp-4899	109	25	service	service	NOUN
fnp-4899	109	26	)	)	PUNCT
fnp-4899	109	27	,	,	PUNCT
fnp-4899	109	28	with	with	ADP
fnp-4899	109	29	294	294	NUM
fnp-4899	109	30	positive	positive	ADJ
fnp-4899	109	31	and	and	CCONJ
fnp-4899	109	32	70	70	NUM
fnp-4899	109	33	negative	negative	ADJ
fnp-4899	109	34	for	for	ADP
fnp-4899	109	35	cte	cte	NOUN
fnp-4899	109	36	.	.	PUNCT
fnp-4899	110	1	in	in	ADP
fnp-4899	110	2	addition	addition	NOUN
fnp-4899	110	3	to	to	ADP
fnp-4899	110	4	disease	disease	NOUN
fnp-4899	110	5	status	status	NOUN
fnp-4899	110	6	,	,	PUNCT
fnp-4899	110	7	the	the	DET
fnp-4899	110	8	investigators	investigator	NOUN
fnp-4899	110	9	were	be	AUX
fnp-4899	110	10	able	able	ADJ
fnp-4899	110	11	to	to	PART
fnp-4899	110	12	explore	explore	VERB
fnp-4899	110	13	a	a	DET
fnp-4899	110	14	series	series	NOUN
fnp-4899	110	15	of	of	ADP
fnp-4899	110	16	diseases	disease	NOUN
fnp-4899	110	17	relevant	relevant	ADJ
fnp-4899	110	18	endophenotypes	endophenotype	NOUN
fnp-4899	110	19	,	,	PUNCT
fnp-4899	110	20	including	include	VERB
fnp-4899	110	21	quantitative	quantitative	ADJ
fnp-4899	110	22	and	and	CCONJ
fnp-4899	110	23	semiquantitative	semiquantitative	ADJ
fnp-4899	110	24	tau	tau	PROPN
fnp-4899	110	25	pathology	pathology	NOUN
fnp-4899	110	26	burden	burden	NOUN
fnp-4899	110	27	assessments	assessment	NOUN
fnp-4899	110	28	.	.	PUNCT
fnp-4899	111	1	they	they	PRON
fnp-4899	111	2	found	find	VERB
fnp-4899	111	3	an	an	DET
fnp-4899	111	4	association	association	NOUN
fnp-4899	111	5	between	between	ADP
fnp-4899	111	6	tau	tau	PROPN
fnp-4899	111	7	pathology	pathology	NOUN
fnp-4899	111	8	burden	burden	NOUN
fnp-4899	111	9	across	across	ADP
fnp-4899	111	10	multiple	multiple	ADJ
fnp-4899	111	11	cortical	cortical	ADJ
fnp-4899	111	12	regions	region	NOUN
fnp-4899	111	13	and	and	CCONJ
fnp-4899	111	14	the	the	DET
fnp-4899	111	15	amygdala	amygdala	NOUN
fnp-4899	111	16	as	as	ADV
fnp-4899	111	17	well	well	ADV
fnp-4899	111	18	as	as	ADP
fnp-4899	111	19	cte	cte	NOUN
fnp-4899	111	20	stage	stage	NOUN
fnp-4899	111	21	among	among	ADP
fnp-4899	111	22	brain	brain	NOUN
fnp-4899	111	23	donors	donor	NOUN
fnp-4899	111	24	over	over	ADP
fnp-4899	111	25	65	65	NUM
fnp-4899	111	26	years	year	NOUN
fnp-4899	111	27	of	of	ADP
fnp-4899	111	28	age	age	NOUN
fnp-4899	111	29	at	at	ADP
fnp-4899	111	30	death	death	NOUN
fnp-4899	111	31	.	.	PUNCT
fnp-4899	112	1	the	the	DET
fnp-4899	112	2	presence	presence	NOUN
fnp-4899	112	3	of	of	ADP
fnp-4899	112	4	a	a	DET
fnp-4899	112	5	apoeε4	apoeε4	NOUN
fnp-4899	112	6	was	be	AUX
fnp-4899	112	7	equivalent	equivalent	ADJ
fnp-4899	112	8	to	to	ADP
fnp-4899	112	9	7	7	NUM
fnp-4899	112	10	years	year	NOUN
fnp-4899	112	11	of	of	ADP
fnp-4899	112	12	playing	play	VERB
fnp-4899	112	13	football	football	NOUN
fnp-4899	112	14	.	.	PUNCT
fnp-4899	113	1	this	this	DET
fnp-4899	113	2	association	association	NOUN
fnp-4899	113	3	remained	remain	VERB
fnp-4899	113	4	even	even	ADV
fnp-4899	113	5	after	after	ADP
fnp-4899	113	6	accounting	account	VERB
fnp-4899	113	7	for	for	ADP
fnp-4899	113	8	amyloid	amyloid	NOUN
fnp-4899	113	9	plaque	plaque	NOUN
fnp-4899	113	10	status	status	NOUN
fnp-4899	113	11	.	.	PUNCT
fnp-4899	114	1	these	these	DET
fnp-4899	114	2	findings	finding	NOUN
fnp-4899	114	3	provide	provide	VERB
fnp-4899	114	4	the	the	DET
fnp-4899	114	5	strongest	strong	ADJ
fnp-4899	114	6	evidence	evidence	NOUN
fnp-4899	114	7	to	to	ADP
fnp-4899	114	8	date	date	NOUN
fnp-4899	114	9	that	that	SCONJ
fnp-4899	114	10	apoeε4	apoeε4	PROPN
fnp-4899	114	11	is	be	AUX
fnp-4899	114	12	a	a	DET
fnp-4899	114	13	risk	risk	NOUN
fnp-4899	114	14	factor	factor	NOUN
fnp-4899	114	15	for	for	ADP
fnp-4899	114	16	cte	cte	PROPN
fnp-4899	114	17	.	.	PROPN
fnp-4899	114	18	8	8	NUM
fnp-4899	114	19	.	.	PUNCT
fnp-4899	114	20	unraveling	unravel	VERB
fnp-4899	114	21	genetic	genetic	ADJ
fnp-4899	114	22	influences	influence	NOUN
fnp-4899	114	23	on	on	ADP
fnp-4899	114	24	microglia	microglia	NOUN
fnp-4899	114	25	in	in	ADP
fnp-4899	114	26	neurodegeneration	neurodegeneration	NOUN
fnp-4899	114	27	understanding	understand	VERB
fnp-4899	114	28	the	the	DET
fnp-4899	114	29	contribution	contribution	NOUN
fnp-4899	114	30	of	of	ADP
fnp-4899	114	31	microglia	microglia	NOUN
fnp-4899	114	32	to	to	ADP
fnp-4899	114	33	the	the	DET
fnp-4899	114	34	pathogenesis	pathogenesis	NOUN
fnp-4899	114	35	of	of	ADP
fnp-4899	114	36	degenerative	degenerative	ADJ
fnp-4899	114	37	brain	brain	NOUN
fnp-4899	114	38	disorders	disorder	NOUN
fnp-4899	114	39	continues	continue	VERB
fnp-4899	114	40	to	to	PART
fnp-4899	114	41	increase	increase	VERB
fnp-4899	114	42	in	in	ADP
fnp-4899	114	43	relevance	relevance	NOUN
fnp-4899	114	44	.	.	PUNCT
fnp-4899	115	1	microglia	microglia	ADJ
fnp-4899	115	2	mediate	mediate	VERB
fnp-4899	115	3	numerous	numerous	ADJ
fnp-4899	115	4	essential	essential	ADJ
fnp-4899	115	5	functions	function	NOUN
fnp-4899	115	6	such	such	ADJ
fnp-4899	115	7	as	as	ADP
fnp-4899	115	8	inflammation	inflammation	NOUN
fnp-4899	115	9	,	,	PUNCT
fnp-4899	115	10	injury	injury	NOUN
fnp-4899	115	11	repair	repair	NOUN
fnp-4899	115	12	,	,	PUNCT
fnp-4899	115	13	maintenance	maintenance	NOUN
fnp-4899	115	14	of	of	ADP
fnp-4899	115	15	brain	brain	NOUN
fnp-4899	115	16	networks	network	NOUN
fnp-4899	115	17	,	,	PUNCT
fnp-4899	115	18	and	and	CCONJ
fnp-4899	115	19	neurodevelopment	neurodevelopment	ADJ
fnp-4899	115	20	.	.	PUNCT
fnp-4899	116	1	they	they	PRON
fnp-4899	116	2	exhibit	exhibit	VERB
fnp-4899	116	3	dynamic	dynamic	ADJ
fnp-4899	116	4	characteristics	characteristic	NOUN
fnp-4899	116	5	and	and	CCONJ
fnp-4899	116	6	can	can	AUX
fnp-4899	116	7	have	have	VERB
fnp-4899	116	8	distinct	distinct	ADJ
fnp-4899	116	9	phenotypes	phenotype	NOUN
fnp-4899	116	10	and	and	CCONJ
fnp-4899	116	11	functions	function	NOUN
fnp-4899	116	12	depending	depend	VERB
fnp-4899	116	13	on	on	ADP
fnp-4899	116	14	environmental	environmental	ADJ
fnp-4899	116	15	signals	signal	NOUN
fnp-4899	116	16	,	,	PUNCT
fnp-4899	116	17	brain	brain	NOUN
fnp-4899	116	18	regions	region	NOUN
fnp-4899	116	19	,	,	PUNCT
fnp-4899	116	20	age	age	NOUN
fnp-4899	116	21	,	,	PUNCT
fnp-4899	116	22	and	and	CCONJ
fnp-4899	116	23	disease	disease	NOUN
fnp-4899	116	24	pathologies	pathology	NOUN
fnp-4899	116	25	.	.	PUNCT
fnp-4899	117	1	previous	previous	ADJ
fnp-4899	117	2	studies	study	NOUN
fnp-4899	117	3	have	have	AUX
fnp-4899	117	4	documented	document	VERB
fnp-4899	117	5	changes	change	NOUN
fnp-4899	117	6	in	in	ADP
fnp-4899	117	7	microglial	microglial	ADJ
fnp-4899	117	8	density	density	NOUN
fnp-4899	117	9	,	,	PUNCT
fnp-4899	117	10	morphology	morphology	NOUN
fnp-4899	117	11	,	,	PUNCT
fnp-4899	117	12	and	and	CCONJ
fnp-4899	117	13	gene	gene	NOUN
fnp-4899	117	14	expression	expression	NOUN
fnp-4899	117	15	in	in	ADP
fnp-4899	117	16	postmortem	postmortem	NOUN
fnp-4899	117	17	brain	brain	NOUN
fnp-4899	117	18	tissue	tissue	NOUN
fnp-4899	117	19	from	from	ADP
fnp-4899	117	20	individuals	individual	NOUN
fnp-4899	117	21	with	with	ADP
fnp-4899	117	22	neurological	neurological	ADJ
fnp-4899	117	23	and	and	CCONJ
fnp-4899	117	24	psychiatric	psychiatric	ADJ
fnp-4899	117	25	disorders	disorder	NOUN
fnp-4899	117	26	,	,	PUNCT
fnp-4899	117	27	suggesting	suggest	VERB
fnp-4899	117	28	their	their	PRON
fnp-4899	117	29	involvement	involvement	NOUN
fnp-4899	117	30	in	in	ADP
fnp-4899	117	31	numerous	numerous	ADJ
fnp-4899	117	32	disease	disease	NOUN
fnp-4899	117	33	processes	process	NOUN
fnp-4899	117	34	.	.	PUNCT
fnp-4899	118	1	recent	recent	ADJ
fnp-4899	118	2	genetic	genetic	ADJ
fnp-4899	118	3	evidence	evidence	NOUN
fnp-4899	118	4	has	have	AUX
fnp-4899	118	5	also	also	ADV
fnp-4899	118	6	strongly	strongly	ADV
fnp-4899	118	7	implicated	implicate	VERB
fnp-4899	118	8	myeloid	myeloid	ADJ
fnp-4899	118	9	cells	cell	NOUN
fnp-4899	118	10	,	,	PUNCT
fnp-4899	118	11	including	include	VERB
fnp-4899	118	12	microglia	microglia	NOUN
fnp-4899	118	13	.	.	PUNCT
fnp-4899	119	1	to	to	PART
fnp-4899	119	2	better	well	ADV
fnp-4899	119	3	understand	understand	VERB
fnp-4899	119	4	the	the	DET
fnp-4899	119	5	potential	potential	ADJ
fnp-4899	119	6	causal	causal	ADJ
fnp-4899	119	7	role	role	NOUN
fnp-4899	119	8	of	of	ADP
fnp-4899	119	9	microglia	microglia	NOUN
fnp-4899	119	10	and	and	CCONJ
fnp-4899	119	11	perhaps	perhaps	ADV
fnp-4899	119	12	identify	identify	VERB
fnp-4899	119	13	therapeutic	therapeutic	ADJ
fnp-4899	119	14	targets	target	NOUN
fnp-4899	119	15	,	,	PUNCT
fnp-4899	119	16	it	it	PRON
fnp-4899	119	17	is	be	AUX
fnp-4899	119	18	crucial	crucial	ADJ
fnp-4899	119	19	to	to	PART
fnp-4899	119	20	determine	determine	VERB
fnp-4899	119	21	the	the	DET
fnp-4899	119	22	genes	gene	NOUN
fnp-4899	119	23	influenced	influence	VERB
fnp-4899	119	24	by	by	ADP
fnp-4899	119	25	disease	disease	NOUN
fnp-4899	119	26	-	-	PUNCT
fnp-4899	119	27	associated	associate	VERB
fnp-4899	119	28	genetic	genetic	ADJ
fnp-4899	119	29	variants	variant	NOUN
fnp-4899	119	30	.	.	PUNCT
fnp-4899	120	1	however	however	ADV
fnp-4899	120	2	,	,	PUNCT
fnp-4899	120	3	this	this	PRON
fnp-4899	120	4	is	be	AUX
fnp-4899	120	5	challenging	challenge	VERB
fnp-4899	120	6	due	due	ADJ
fnp-4899	120	7	to	to	ADP
fnp-4899	120	8	the	the	DET
fnp-4899	120	9	complex	complex	ADJ
fnp-4899	120	10	regulatory	regulatory	ADJ
fnp-4899	120	11	mechanisms	mechanism	NOUN
fnp-4899	120	12	involved	involve	VERB
fnp-4899	120	13	,	,	PUNCT
fnp-4899	120	14	especially	especially	ADV
fnp-4899	120	15	when	when	SCONJ
fnp-4899	120	16	considering	consider	VERB
fnp-4899	120	17	variants	variant	NOUN
fnp-4899	120	18	located	locate	VERB
fnp-4899	120	19	outside	outside	ADP
fnp-4899	120	20	protein	protein	NOUN
fnp-4899	120	21	-	-	PUNCT
fnp-4899	120	22	coding	code	VERB
fnp-4899	120	23	regions	region	NOUN
fnp-4899	120	24	.	.	PUNCT
fnp-4899	121	1	integrating	integrate	VERB
fnp-4899	121	2	genetic	genetic	ADJ
fnp-4899	121	3	and	and	CCONJ
fnp-4899	121	4	transcriptomic	transcriptomic	ADJ
fnp-4899	121	5	analyses	analysis	NOUN
fnp-4899	121	6	can	can	AUX
fnp-4899	121	7	help	help	AUX
fnp-4899	121	8	identify	identify	VERB
fnp-4899	121	9	quantitative	quantitative	ADJ
fnp-4899	121	10	trait	trait	NOUN
fnp-4899	121	11	loci	loci	NOUN
fnp-4899	121	12	(	(	PUNCT
fnp-4899	121	13	qtls	qtls	PROPN
fnp-4899	121	14	)	)	PUNCT
fnp-4899	121	15	and	and	CCONJ
fnp-4899	121	16	elucidate	elucidate	VERB
fnp-4899	121	17	gene	gene	NOUN
fnp-4899	121	18	-	-	PUNCT
fnp-4899	121	19	gene	gene	NOUN
fnp-4899	121	20	variant	variant	NOUN
fnp-4899	121	21	relationships	relationship	NOUN
fnp-4899	121	22	.	.	PUNCT
fnp-4899	122	1	although	although	SCONJ
fnp-4899	122	2	recent	recent	ADJ
fnp-4899	122	3	efforts	effort	NOUN
fnp-4899	122	4	have	have	AUX
fnp-4899	122	5	detected	detect	VERB
fnp-4899	122	6	expression	expression	NOUN
fnp-4899	122	7	qtls	qtls	NOUN
fnp-4899	122	8	(	(	PUNCT
fnp-4899	122	9	eqtls	eqtls	PROPN
fnp-4899	122	10	)	)	PUNCT
fnp-4899	122	11	in	in	ADP
fnp-4899	122	12	microglia	microglia	NOUN
fnp-4899	122	13	and	and	CCONJ
fnp-4899	122	14	their	their	PRON
fnp-4899	122	15	overlap	overlap	NOUN
fnp-4899	122	16	with	with	ADP
fnp-4899	122	17	ad	ad	NOUN
fnp-4899	122	18	loci	locus	NOUN
fnp-4899	122	19	,	,	PUNCT
fnp-4899	122	20	larger	large	ADJ
fnp-4899	122	21	sample	sample	NOUN
fnp-4899	122	22	sizes	size	NOUN
fnp-4899	122	23	are	be	AUX
fnp-4899	122	24	needed	need	VERB
fnp-4899	122	25	.	.	PUNCT
fnp-4899	123	1	in	in	ADP
fnp-4899	123	2	a	a	DET
fnp-4899	123	3	study	study	NOUN
fnp-4899	123	4	conducted	conduct	VERB
fnp-4899	123	5	by	by	ADP
fnp-4899	123	6	lopes	lopes	PROPN
fnp-4899	123	7	et	et	PROPN
fnp-4899	123	8	al	al	PROPN
fnp-4899	123	9	.	.	PROPN
fnp-4899	123	10	,	,	PUNCT
fnp-4899	123	11	a	a	DET
fnp-4899	123	12	team	team	NOUN
fnp-4899	123	13	of	of	ADP
fnp-4899	123	14	researchers	researcher	NOUN
fnp-4899	123	15	performed	perform	VERB
fnp-4899	123	16	transcriptome	transcriptome	ADJ
fnp-4899	123	17	analysis	analysis	NOUN
fnp-4899	123	18	on	on	ADP
fnp-4899	123	19	255	255	NUM
fnp-4899	123	20	primary	primary	ADJ
fnp-4899	123	21	human	human	ADJ
fnp-4899	123	22	microglial	microglial	ADJ
fnp-4899	123	23	isolates	isolate	NOUN
fnp-4899	123	24	obtained	obtain	VERB
fnp-4899	123	25	from	from	ADP
fnp-4899	123	26	multiple	multiple	ADJ
fnp-4899	123	27	brain	brain	NOUN
fnp-4899	123	28	regions	region	NOUN
fnp-4899	123	29	of	of	ADP
fnp-4899	123	30	100	100	NUM
fnp-4899	123	31	individuals	individual	NOUN
fnp-4899	123	32	obtained	obtain	VERB
fnp-4899	123	33	fresh	fresh	ADV
fnp-4899	123	34	at	at	ADP
fnp-4899	123	35	autopsy	autopsy	ADJ
fnp-4899	123	36	(	(	PUNCT
fnp-4899	123	37	lopes	lope	NOUN
fnp-4899	123	38	et	et	PROPN
fnp-4899	123	39	al	al	PROPN
fnp-4899	123	40	.	.	PROPN
fnp-4899	123	41	,	,	PUNCT
fnp-4899	123	42	2022	2022	NUM
fnp-4899	123	43	)	)	PUNCT
fnp-4899	123	44	.	.	PUNCT
fnp-4899	124	1	they	they	PRON
fnp-4899	124	2	investigated	investigate	VERB
fnp-4899	124	3	factors	factor	NOUN
fnp-4899	124	4	contributing	contribute	VERB
fnp-4899	124	5	to	to	ADP
fnp-4899	124	6	microglial	microglial	ADJ
fnp-4899	124	7	heterogeneity	heterogeneity	NOUN
fnp-4899	124	8	,	,	PUNCT
fnp-4899	124	9	such	such	ADJ
fnp-4899	124	10	as	as	ADP
fnp-4899	124	11	brain	brain	NOUN
fnp-4899	124	12	region	region	NOUN
fnp-4899	124	13	and	and	CCONJ
fnp-4899	124	14	aging	aging	NOUN
fnp-4899	124	15	.	.	PUNCT
fnp-4899	125	1	through	through	ADP
fnp-4899	125	2	mapping	mapping	NOUN
fnp-4899	125	3	of	of	ADP
fnp-4899	125	4	expression	expression	NOUN
fnp-4899	125	5	and	and	CCONJ
fnp-4899	125	6	splicing	splice	VERB
fnp-4899	125	7	quantitative	quantitative	ADJ
fnp-4899	125	8	trait	trait	NOUN
fnp-4899	125	9	loci	locus	NOUN
fnp-4899	125	10	,	,	PUNCT
fnp-4899	125	11	the	the	DET
fnp-4899	125	12	study	study	NOUN
fnp-4899	125	13	revealed	reveal	VERB
fnp-4899	125	14	that	that	SCONJ
fnp-4899	125	15	numerous	numerous	ADJ
fnp-4899	125	16	susceptibility	susceptibility	NOUN
fnp-4899	125	17	loci	locus	NOUN
fnp-4899	125	18	for	for	ADP
fnp-4899	125	19	neurological	neurological	ADJ
fnp-4899	125	20	diseases	disease	NOUN
fnp-4899	125	21	are	be	AUX
fnp-4899	125	22	mediated	mediate	VERB
fnp-4899	125	23	by	by	ADP
fnp-4899	125	24	gene	gene	NOUN
fnp-4899	125	25	expression	expression	NOUN
fnp-4899	125	26	or	or	CCONJ
fnp-4899	125	27	splicing	splicing	NOUN
fnp-4899	125	28	in	in	ADP
fnp-4899	125	29	microglia	microglia	NOUN
fnp-4899	125	30	.	.	PUNCT
fnp-4899	126	1	notably	notably	ADV
fnp-4899	126	2	,	,	PUNCT
fnp-4899	126	3	the	the	DET
fnp-4899	126	4	researchers	researcher	NOUN
fnp-4899	126	5	identified	identify	VERB
fnp-4899	126	6	candidate	candidate	NOUN
fnp-4899	126	7	causal	causal	ADJ
fnp-4899	126	8	variants	variant	NOUN
fnp-4899	126	9	within	within	ADP
fnp-4899	126	10	microglia	microglia	ADJ
fnp-4899	126	11	-	-	ADJ
fnp-4899	126	12	specific	specific	ADJ
fnp-4899	126	13	enhancers	enhancer	NOUN
fnp-4899	126	14	,	,	PUNCT
fnp-4899	126	15	including	include	VERB
fnp-4899	126	16	associations	association	NOUN
fnp-4899	126	17	between	between	ADP
fnp-4899	126	18	microglial	microglial	ADJ
fnp-4899	126	19	expression	expression	NOUN
fnp-4899	126	20	of	of	ADP
fnp-4899	126	21	usp6nl	usp6nl	PROPN
fnp-4899	126	22	and	and	CCONJ
fnp-4899	126	23	ad	ad	NOUN
fnp-4899	126	24	,	,	PUNCT
fnp-4899	126	25	as	as	ADV
fnp-4899	126	26	well	well	ADV
fnp-4899	126	27	as	as	ADP
fnp-4899	126	28	p2ry12	p2ry12	PROPN
fnp-4899	126	29	and	and	CCONJ
fnp-4899	126	30	parkinson	parkinson	NOUN
fnp-4899	126	31	’s	’s	PART
fnp-4899	126	32	disease	disease	NOUN
fnp-4899	126	33	.	.	PUNCT
fnp-4899	127	1	overall	overall	ADV
fnp-4899	127	2	,	,	PUNCT
fnp-4899	127	3	this	this	DET
fnp-4899	127	4	study	study	NOUN
fnp-4899	127	5	provides	provide	VERB
fnp-4899	127	6	a	a	DET
fnp-4899	127	7	comprehensive	comprehensive	ADJ
fnp-4899	127	8	catalog	catalog	NOUN
fnp-4899	127	9	of	of	ADP
fnp-4899	127	10	genetic	genetic	ADJ
fnp-4899	127	11	effects	effect	NOUN
fnp-4899	127	12	on	on	ADP
fnp-4899	127	13	the	the	DET
fnp-4899	127	14	microglial	microglial	ADJ
fnp-4899	127	15	transcriptome	transcriptome	NOUN
fnp-4899	127	16	and	and	CCONJ
fnp-4899	127	17	presents	present	VERB
fnp-4899	127	18	potential	potential	ADJ
fnp-4899	127	19	functional	functional	ADJ
fnp-4899	127	20	variants	variant	NOUN
fnp-4899	127	21	relevant	relevant	ADJ
fnp-4899	127	22	to	to	ADP
fnp-4899	127	23	neurological	neurological	ADJ
fnp-4899	127	24	and	and	CCONJ
fnp-4899	127	25	psychiatric	psychiatric	ADJ
fnp-4899	127	26	disorders	disorder	NOUN
fnp-4899	127	27	.	.	PUNCT
fnp-4899	128	1	9	9	X
fnp-4899	128	2	.	.	X
fnp-4899	128	3	a	a	DET
fnp-4899	128	4	postmortem	postmortem	NOUN
fnp-4899	128	5	study	study	NOUN
fnp-4899	128	6	examines	examine	VERB
fnp-4899	128	7	the	the	DET
fnp-4899	128	8	dual	dual	ADV
fnp-4899	128	9	-	-	PUNCT
fnp-4899	128	10	hit	hit	VERB
fnp-4899	128	11	hypothesis	hypothesis	NOUN
fnp-4899	128	12	of	of	ADP
fnp-4899	128	13	parkinson	parkinson	NOUN
fnp-4899	128	14	’s	’s	PART
fnp-4899	128	15	disease	disease	NOUN
fnp-4899	128	16	pathoanatomically	pathoanatomically	ADV
fnp-4899	128	17	mapping	map	VERB
fnp-4899	128	18	the	the	DET
fnp-4899	128	19	initiation	initiation	NOUN
fnp-4899	128	20	and	and	CCONJ
fnp-4899	128	21	progression	progression	NOUN
fnp-4899	128	22	of	of	ADP
fnp-4899	128	23	lewy	lewy	PROPN
fnp-4899	128	24	body	body	PROPN
fnp-4899	128	25	pathology	pathology	NOUN
fnp-4899	128	26	through	through	ADP
fnp-4899	128	27	the	the	DET
fnp-4899	128	28	brain	brain	NOUN
fnp-4899	128	29	is	be	AUX
fnp-4899	128	30	a	a	DET
fnp-4899	128	31	critical	critical	ADJ
fnp-4899	128	32	aspect	aspect	NOUN
fnp-4899	128	33	of	of	ADP
fnp-4899	128	34	our	our	PRON
fnp-4899	128	35	understanding	understanding	NOUN
fnp-4899	128	36	of	of	ADP
fnp-4899	128	37	neurodegeneration	neurodegeneration	NOUN
fnp-4899	128	38	.	.	PUNCT
fnp-4899	129	1	one	one	NUM
fnp-4899	129	2	hypothesis	hypothesis	NOUN
fnp-4899	129	3	,	,	PUNCT
fnp-4899	129	4	first	first	ADV
fnp-4899	129	5	suggested	suggest	VERB
fnp-4899	129	6	by	by	ADP
fnp-4899	129	7	braak	braak	NOUN
fnp-4899	129	8	and	and	CCONJ
fnp-4899	129	9	colleagues	colleague	NOUN
fnp-4899	129	10	,	,	PUNCT
fnp-4899	129	11	is	be	AUX
fnp-4899	129	12	that	that	SCONJ
fnp-4899	129	13	there	there	PRON
fnp-4899	129	14	is	be	VERB
fnp-4899	129	15	a	a	DET
fnp-4899	129	16	dual	dual	ADV
fnp-4899	129	17	-	-	PUNCT
fnp-4899	129	18	hit	hit	VERB
fnp-4899	129	19	,	,	PUNCT
fnp-4899	129	20	with	with	ADP
fnp-4899	129	21	simultaneous	simultaneous	ADJ
fnp-4899	129	22	involvement	involvement	NOUN
fnp-4899	129	23	of	of	ADP
fnp-4899	129	24	the	the	DET
fnp-4899	129	25	olfactory	olfactory	NOUN
fnp-4899	129	26	bulb	bulb	NOUN
fnp-4899	129	27	and	and	CCONJ
fnp-4899	129	28	dorsal	dorsal	NOUN
fnp-4899	129	29	motor	motor	NOUN
fnp-4899	129	30	nucleus	nucleus	NOUN
fnp-4899	129	31	of	of	ADP
fnp-4899	129	32	the	the	DET
fnp-4899	129	33	vagus	vagus	NOUN
fnp-4899	129	34	that	that	PRON
fnp-4899	129	35	underlies	underlie	VERB
fnp-4899	129	36	hyposmia	hyposmia	NOUN
fnp-4899	129	37	and	and	CCONJ
fnp-4899	129	38	autonomic	autonomic	ADJ
fnp-4899	129	39	symptoms	symptom	NOUN
fnp-4899	129	40	,	,	PUNCT
fnp-4899	129	41	respectively	respectively	ADV
fnp-4899	129	42	.	.	PUNCT
fnp-4899	130	1	early	early	ADJ
fnp-4899	130	2	studies	study	NOUN
fnp-4899	130	3	had	have	VERB
fnp-4899	130	4	mandatory	mandatory	ADJ
fnp-4899	130	5	inclusion	inclusion	NOUN
fnp-4899	130	6	of	of	ADP
fnp-4899	130	7	lewy	lewy	PROPN
fnp-4899	130	8	pathology	pathology	PROPN
fnp-4899	130	9	in	in	ADP
fnp-4899	130	10	the	the	DET
fnp-4899	130	11	dorsal	dorsal	NOUN
fnp-4899	130	12	motor	motor	NOUN
fnp-4899	130	13	nucleus	nucleus	PROPN
fnp-4899	130	14	as	as	ADP
fnp-4899	130	15	an	an	DET
fnp-4899	130	16	inclusion	inclusion	NOUN
fnp-4899	130	17	criterion	criterion	NOUN
fnp-4899	130	18	,	,	PUNCT
fnp-4899	130	19	potentially	potentially	ADV
fnp-4899	130	20	biasing	biasing	ADJ
fnp-4899	130	21	against	against	ADP
fnp-4899	130	22	cases	case	NOUN
fnp-4899	130	23	with	with	ADP
fnp-4899	130	24	lewy	lewy	ADJ
fnp-4899	130	25	bodies	body	NOUN
fnp-4899	130	26	in	in	ADP
fnp-4899	130	27	the	the	DET
fnp-4899	130	28	olfactory	olfactory	NOUN
fnp-4899	130	29	bulb	bulb	NOUN
fnp-4899	130	30	alone	alone	ADV
fnp-4899	130	31	.	.	PUNCT
fnp-4899	131	1	nevertheless	nevertheless	ADV
fnp-4899	131	2	,	,	PUNCT
fnp-4899	131	3	this	this	DET
fnp-4899	131	4	hypothesis	hypothesis	NOUN
fnp-4899	131	5	is	be	AUX
fnp-4899	131	6	debated	debate	VERB
fnp-4899	131	7	and	and	CCONJ
fnp-4899	131	8	yet	yet	ADV
fnp-4899	131	9	has	have	AUX
fnp-4899	131	10	spawned	spawn	VERB
fnp-4899	131	11	many	many	ADJ
fnp-4899	131	12	clinical	clinical	ADJ
fnp-4899	131	13	studies	study	NOUN
fnp-4899	131	14	aimed	aim	VERB
fnp-4899	131	15	at	at	ADP
fnp-4899	131	16	understanding	understand	VERB
fnp-4899	131	17	potential	potential	ADJ
fnp-4899	131	18	initiating	initiate	VERB
fnp-4899	131	19	factors	factor	NOUN
fnp-4899	131	20	.	.	PUNCT
fnp-4899	132	1	little	little	ADJ
fnp-4899	132	2	work	work	NOUN
fnp-4899	132	3	has	have	AUX
fnp-4899	132	4	been	be	AUX
fnp-4899	132	5	done	do	VERB
fnp-4899	132	6	to	to	PART
fnp-4899	132	7	test	test	VERB
fnp-4899	132	8	the	the	DET
fnp-4899	132	9	hypothesis	hypothesis	NOUN
fnp-4899	132	10	in	in	ADP
fnp-4899	132	11	the	the	DET
fnp-4899	132	12	neuropathological	neuropathological	ADJ
fnp-4899	132	13	setting	setting	NOUN
fnp-4899	132	14	.	.	PUNCT
fnp-4899	133	1	in	in	ADP
fnp-4899	133	2	a	a	DET
fnp-4899	133	3	study	study	NOUN
fnp-4899	133	4	by	by	ADP
fnp-4899	133	5	borghammer	borghammer	PROPN
fnp-4899	133	6	et	et	PROPN
fnp-4899	133	7	al	al	PROPN
fnp-4899	133	8	.	.	PROPN
fnp-4899	133	9	,	,	PUNCT
fnp-4899	133	10	investigators	investigator	NOUN
fnp-4899	133	11	re	re	VERB
fnp-4899	133	12	-	-	VERB
fnp-4899	133	13	analyzed	analyze	VERB
fnp-4899	133	14	two	two	NUM
fnp-4899	133	15	large	large	ADJ
fnp-4899	133	16	human	human	ADJ
fnp-4899	133	17	post	post	ADJ
fnp-4899	133	18	-	-	ADJ
fnp-4899	133	19	mortem	mortem	ADJ
fnp-4899	133	20	autopsy	autopsy	ADJ
fnp-4899	133	21	datasets	dataset	NOUN
fnp-4899	133	22	that	that	PRON
fnp-4899	133	23	included	include	VERB
fnp-4899	133	24	mild	mild	ADJ
fnp-4899	133	25	lewy	lewy	ADJ
fnp-4899	133	26	body	body	NOUN
fnp-4899	133	27	disease	disease	NOUN
fnp-4899	133	28	cases	case	NOUN
fnp-4899	133	29	(	(	PUNCT
fnp-4899	133	30	borghammer	borghammer	PROPN
fnp-4899	133	31	et	et	PROPN
fnp-4899	133	32	al	al	PROPN
fnp-4899	133	33	.	.	PROPN
fnp-4899	133	34	,	,	PUNCT
fnp-4899	133	35	2022	2022	NUM
fnp-4899	133	36	)	)	PUNCT
fnp-4899	133	37	.	.	PUNCT
fnp-4899	134	1	they	they	PRON
fnp-4899	134	2	found	find	VERB
fnp-4899	134	3	that	that	SCONJ
fnp-4899	134	4	cases	case	NOUN
fnp-4899	134	5	with	with	ADP
fnp-4899	134	6	alpha	alpha	NOUN
fnp-4899	134	7	-	-	PUNCT
fnp-4899	134	8	synuclein	synuclein	NOUN
fnp-4899	134	9	immunopositivity	immunopositivity	NOUN
fnp-4899	134	10	in	in	ADP
fnp-4899	134	11	the	the	DET
fnp-4899	134	12	peripheral	peripheral	ADJ
fnp-4899	134	13	autonomic	autonomic	ADJ
fnp-4899	134	14	nervous	nervous	ADJ
fnp-4899	134	15	system	system	NOUN
fnp-4899	134	16	and	and	CCONJ
fnp-4899	134	17	lower	low	ADJ
fnp-4899	134	18	brainstem	brainstem	NOUN
fnp-4899	134	19	infrequently	infrequently	ADV
fnp-4899	134	20	displayed	display	VERB
fnp-4899	134	21	pathology	pathology	NOUN
fnp-4899	134	22	in	in	ADP
fnp-4899	134	23	the	the	DET
fnp-4899	134	24	olfactory	olfactory	NOUN
fnp-4899	134	25	bulb	bulb	NOUN
fnp-4899	134	26	(	(	PUNCT
fnp-4899	134	27	figure	figure	NOUN
fnp-4899	134	28	7	7	NUM
fnp-4899	134	29	)	)	PUNCT
fnp-4899	134	30	.	.	PUNCT
fnp-4899	135	1	conversely	conversely	ADV
fnp-4899	135	2	,	,	PUNCT
fnp-4899	135	3	cases	case	NOUN
fnp-4899	135	4	with	with	ADP
fnp-4899	135	5	mild	mild	ADJ
fnp-4899	135	6	amygdala	amygdala	NOUN
fnp-4899	135	7	-	-	PUNCT
fnp-4899	135	8	predominant	predominant	ADJ
fnp-4899	135	9	lewy	lewy	PROPN
fnp-4899	135	10	body	body	NOUN
fnp-4899	135	11	pathology	pathology	NOUN
fnp-4899	135	12	essentially	essentially	ADV
fnp-4899	135	13	always	always	ADV
fnp-4899	135	14	showed	show	VERB
fnp-4899	135	15	olfactory	olfactory	ADJ
fnp-4899	135	16	bulb	bulb	PROPN
fnp-4899	135	17	pathology	pathology	NOUN
fnp-4899	135	18	.	.	PUNCT
fnp-4899	136	1	together	together	ADV
fnp-4899	136	2	,	,	PUNCT
fnp-4899	136	3	these	these	DET
fnp-4899	136	4	findings	finding	NOUN
fnp-4899	136	5	suggest	suggest	VERB
fnp-4899	136	6	that	that	SCONJ
fnp-4899	136	7	the	the	DET
fnp-4899	136	8	initiation	initiation	NOUN
fnp-4899	136	9	of	of	ADP
fnp-4899	136	10	lewy	lewy	PROPN
fnp-4899	136	11	body	body	PROPN
fnp-4899	136	12	pathology	pathology	NOUN
fnp-4899	136	13	starts	start	VERB
fnp-4899	136	14	either	either	CCONJ
fnp-4899	136	15	in	in	ADP
fnp-4899	136	16	the	the	DET
fnp-4899	136	17	olfactory	olfactory	NOUN
fnp-4899	136	18	bulb	bulb	NOUN
fnp-4899	136	19	or	or	CCONJ
fnp-4899	136	20	enteric	enteric	ADJ
fnp-4899	136	21	nervous	nervous	ADJ
fnp-4899	136	22	system	system	NOUN
fnp-4899	136	23	but	but	CCONJ
fnp-4899	136	24	rarely	rarely	ADV
fnp-4899	136	25	simultaneously	simultaneously	ADV
fnp-4899	136	26	.	.	PUNCT
fnp-4899	137	1	there	there	PRON
fnp-4899	137	2	are	be	VERB
fnp-4899	137	3	a	a	DET
fnp-4899	137	4	number	number	NOUN
fnp-4899	137	5	of	of	ADP
fnp-4899	137	6	important	important	ADJ
fnp-4899	137	7	caveats	caveat	NOUN
fnp-4899	137	8	:	:	PUNCT
fnp-4899	137	9	these	these	DET
fnp-4899	137	10	cases	case	NOUN
fnp-4899	137	11	with	with	ADP
fnp-4899	137	12	mild	mild	ADJ
fnp-4899	137	13	lewy	lewy	ADJ
fnp-4899	137	14	pathology	pathology	NOUN
fnp-4899	137	15	were	be	AUX
fnp-4899	137	16	in	in	ADP
fnp-4899	137	17	a	a	DET
fnp-4899	137	18	prodromal	prodromal	ADJ
fnp-4899	137	19	phase	phase	NOUN
fnp-4899	137	20	but	but	CCONJ
fnp-4899	137	21	might	might	AUX
fnp-4899	137	22	alternatively	alternatively	ADV
fnp-4899	137	23	have	have	AUX
fnp-4899	137	24	not	not	PART
fnp-4899	137	25	progressed	progress	VERB
fnp-4899	137	26	.	.	PUNCT
fnp-4899	138	1	nevertheless	nevertheless	ADV
fnp-4899	138	2	,	,	PUNCT
fnp-4899	138	3	these	these	DET
fnp-4899	138	4	findings	finding	NOUN
fnp-4899	138	5	are	be	AUX
fnp-4899	138	6	an	an	DET
fnp-4899	138	7	important	important	ADJ
fnp-4899	138	8	contribution	contribution	NOUN
fnp-4899	138	9	to	to	ADP
fnp-4899	138	10	our	our	PRON
fnp-4899	138	11	understanding	understanding	NOUN
fnp-4899	138	12	of	of	ADP
fnp-4899	138	13	prion	prion	NOUN
fnp-4899	138	14	-	-	PUNCT
fnp-4899	138	15	like	like	ADJ
fnp-4899	138	16	spreading	spreading	NOUN
fnp-4899	138	17	of	of	ADP
fnp-4899	138	18	lewy	lewy	PROPN
fnp-4899	138	19	neuropathology	neuropathology	NOUN
fnp-4899	138	20	and	and	CCONJ
fnp-4899	138	21	may	may	AUX
fnp-4899	138	22	lead	lead	VERB
fnp-4899	138	23	to	to	ADP
fnp-4899	138	24	better	well	ADJ
fnp-4899	138	25	diagnostics	diagnostic	NOUN
fnp-4899	138	26	and	and	CCONJ
fnp-4899	138	27	advance	advance	VERB
fnp-4899	138	28	our	our	PRON
fnp-4899	138	29	mechanistic	mechanistic	ADJ
fnp-4899	138	30	understanding	understanding	NOUN
fnp-4899	138	31	.	.	PUNCT
fnp-4899	139	1	figure	figure	NOUN
fnp-4899	139	2	7	7	NUM
fnp-4899	139	3	.	.	PUNCT
fnp-4899	139	4	single	single	ADJ
fnp-4899	139	5	-	-	PUNCT
fnp-4899	139	6	hit	hit	VERB
fnp-4899	139	7	hypothesis	hypothesis	NOUN
fnp-4899	139	8	of	of	ADP
fnp-4899	139	9	“	"	PUNCT
fnp-4899	139	10	prion	prion	NOUN
fnp-4899	139	11	-	-	PUNCT
fnp-4899	139	12	like	like	ADJ
fnp-4899	139	13	”	"	PUNCT
fnp-4899	139	14	propagation	propagation	NOUN
fnp-4899	139	15	in	in	ADP
fnp-4899	139	16	lewy	lewy	ADJ
fnp-4899	139	17	body	body	NOUN
fnp-4899	139	18	disease	disease	NOUN
fnp-4899	139	19	.	.	PUNCT
fnp-4899	140	1	a.	a.	NOUN
fnp-4899	140	2	in	in	ADP
fnp-4899	140	3	the	the	DET
fnp-4899	140	4	“	"	PUNCT
fnp-4899	140	5	brain	brain	NOUN
fnp-4899	140	6	-	-	PUNCT
fnp-4899	140	7	first	first	ADJ
fnp-4899	140	8	/	/	SYM
fnp-4899	140	9	olfactory	olfactory	NOUN
fnp-4899	140	10	bulb	bulb	NOUN
fnp-4899	140	11	-	-	PUNCT
fnp-4899	140	12	first	first	ADJ
fnp-4899	140	13	”	"	PUNCT
fnp-4899	140	14	subset	subset	NOUN
fnp-4899	140	15	,	,	PUNCT
fnp-4899	140	16	pathology	pathology	NOUN
fnp-4899	140	17	arises	arise	VERB
fnp-4899	140	18	in	in	ADP
fnp-4899	140	19	the	the	DET
fnp-4899	140	20	olfactory	olfactory	NOUN
fnp-4899	140	21	bulb	bulb	NOUN
fnp-4899	140	22	or	or	CCONJ
fnp-4899	140	23	amygdala	amygdala	VERB
fnp-4899	140	24	and	and	CCONJ
fnp-4899	140	25	rapidly	rapidly	ADV
fnp-4899	140	26	spreads	spread	VERB
fnp-4899	140	27	to	to	PART
fnp-4899	140	28	forebrain	forebrain	VERB
fnp-4899	140	29	structures	structure	NOUN
fnp-4899	140	30	ipsilaterally	ipsilaterally	ADV
fnp-4899	140	31	and	and	CCONJ
fnp-4899	140	32	later	later	ADV
fnp-4899	140	33	bilaterally	bilaterally	ADV
fnp-4899	140	34	.	.	PUNCT
fnp-4899	141	1	b.	b.	PROPN
fnp-4899	142	1	in	in	ADP
fnp-4899	142	2	the	the	DET
fnp-4899	142	3	“	"	PUNCT
fnp-4899	142	4	body	body	NOUN
fnp-4899	142	5	-	-	PUNCT
fnp-4899	142	6	first	first	ADJ
fnp-4899	142	7	”	"	PUNCT
fnp-4899	142	8	subset	subset	NOUN
fnp-4899	142	9	,	,	PUNCT
fnp-4899	142	10	pathology	pathology	NOUN
fnp-4899	142	11	spreads	spread	VERB
fnp-4899	142	12	to	to	ADP
fnp-4899	142	13	the	the	DET
fnp-4899	142	14	medulla	medulla	NOUN
fnp-4899	142	15	bilaterally	bilaterally	ADV
fnp-4899	142	16	and	and	CCONJ
fnp-4899	142	17	progresses	progress	VERB
fnp-4899	142	18	superiorly	superiorly	ADV
fnp-4899	142	19	.	.	PUNCT
fnp-4899	143	1	(	(	PUNCT
fnp-4899	143	2	reproduced	reproduce	VERB
fnp-4899	143	3	with	with	ADP
fnp-4899	143	4	permission	permission	NOUN
fnp-4899	143	5	under	under	ADP
fnp-4899	143	6	the	the	DET
fnp-4899	143	7	creative	creative	ADJ
fnp-4899	143	8	common	common	ADJ
fnp-4899	143	9	license	license	NOUN
fnp-4899	143	10	from	from	ADP
fnp-4899	143	11	broghammer	broghammer	PROPN
fnp-4899	143	12	et	et	PROPN
fnp-4899	143	13	al	al	PROPN
fnp-4899	143	14	.	.	PROPN
fnp-4899	143	15	,	,	PUNCT
fnp-4899	143	16	2022	2022	NUM
fnp-4899	143	17	)	)	PUNCT
fnp-4899	143	18	.	.	PUNCT
fnp-4899	144	1	10	10	NUM
fnp-4899	144	2	.	.	X
fnp-4899	145	1	deep	deep	ADJ
fnp-4899	145	2	learning	learning	NOUN
fnp-4899	145	3	continues	continue	VERB
fnp-4899	145	4	to	to	PART
fnp-4899	145	5	reshape	reshape	VERB
fnp-4899	145	6	histological	histological	ADJ
fnp-4899	145	7	assessments	assessment	NOUN
fnp-4899	145	8	numerous	numerous	ADJ
fnp-4899	145	9	studies	study	NOUN
fnp-4899	145	10	continue	continue	VERB
fnp-4899	145	11	to	to	PART
fnp-4899	145	12	apply	apply	VERB
fnp-4899	145	13	deep	deep	ADJ
fnp-4899	145	14	learning	learning	NOUN
fnp-4899	145	15	to	to	ADP
fnp-4899	145	16	digital	digital	ADJ
fnp-4899	145	17	whole	whole	ADJ
fnp-4899	145	18	slide	slide	NOUN
fnp-4899	145	19	images	image	NOUN
fnp-4899	145	20	of	of	ADP
fnp-4899	145	21	histological	histological	ADJ
fnp-4899	145	22	sections	section	NOUN
fnp-4899	145	23	of	of	ADP
fnp-4899	145	24	human	human	ADJ
fnp-4899	145	25	brain	brain	NOUN
fnp-4899	145	26	tissue	tissue	NOUN
fnp-4899	145	27	.	.	PUNCT
fnp-4899	146	1	this	this	DET
fnp-4899	146	2	approach	approach	NOUN
fnp-4899	146	3	has	have	AUX
fnp-4899	146	4	been	be	AUX
fnp-4899	146	5	fueled	fuel	VERB
fnp-4899	146	6	by	by	ADP
fnp-4899	146	7	the	the	DET
fnp-4899	146	8	more	more	ADV
fnp-4899	146	9	widespread	widespread	ADJ
fnp-4899	146	10	availability	availability	NOUN
fnp-4899	146	11	of	of	ADP
fnp-4899	146	12	whole	whole	ADJ
fnp-4899	146	13	slide	slide	NOUN
fnp-4899	146	14	image	image	NOUN
fnp-4899	146	15	scanners	scanner	NOUN
fnp-4899	146	16	.	.	PUNCT
fnp-4899	147	1	combined	combine	VERB
fnp-4899	147	2	with	with	ADP
fnp-4899	147	3	both	both	DET
fnp-4899	147	4	next	next	ADJ
fnp-4899	147	5	generation	generation	NOUN
fnp-4899	147	6	deep	deep	ADJ
fnp-4899	147	7	learning	learn	VERB
fnp-4899	147	8	image	image	NOUN
fnp-4899	147	9	analysis	analysis	NOUN
fnp-4899	147	10	models	model	NOUN
fnp-4899	147	11	and	and	CCONJ
fnp-4899	147	12	powerful	powerful	ADJ
fnp-4899	147	13	graphical	graphical	ADJ
fnp-4899	147	14	processing	processing	NOUN
fnp-4899	147	15	units	unit	NOUN
fnp-4899	147	16	,	,	PUNCT
fnp-4899	147	17	there	there	PRON
fnp-4899	147	18	is	be	VERB
fnp-4899	147	19	fertile	fertile	ADJ
fnp-4899	147	20	ground	ground	NOUN
fnp-4899	147	21	for	for	ADP
fnp-4899	147	22	innovation	innovation	NOUN
fnp-4899	147	23	.	.	PUNCT
fnp-4899	148	1	a	a	DET
fnp-4899	148	2	convolutional	convolutional	ADJ
fnp-4899	148	3	neural	neural	ADJ
fnp-4899	148	4	network	network	NOUN
fnp-4899	148	5	(	(	PUNCT
fnp-4899	148	6	cnn	cnn	PROPN
fnp-4899	148	7	)	)	PUNCT
fnp-4899	148	8	is	be	AUX
fnp-4899	148	9	a	a	DET
fnp-4899	148	10	variety	variety	NOUN
fnp-4899	148	11	of	of	ADP
fnp-4899	148	12	model	model	NOUN
fnp-4899	148	13	that	that	PRON
fnp-4899	148	14	is	be	AUX
fnp-4899	148	15	fine	fine	ADV
fnp-4899	148	16	tuned	tune	VERB
fnp-4899	148	17	for	for	ADP
fnp-4899	148	18	processing	process	VERB
fnp-4899	148	19	image	image	NOUN
fnp-4899	148	20	data	datum	NOUN
fnp-4899	148	21	.	.	PUNCT
fnp-4899	149	1	cnns	cnns	PROPN
fnp-4899	149	2	have	have	AUX
fnp-4899	149	3	been	be	AUX
fnp-4899	149	4	applied	apply	VERB
fnp-4899	149	5	to	to	ADP
fnp-4899	149	6	the	the	DET
fnp-4899	149	7	detection	detection	NOUN
fnp-4899	149	8	of	of	ADP
fnp-4899	149	9	amyloid	amyloid	NOUN
fnp-4899	149	10	plaques	plaque	NOUN
fnp-4899	149	11	,	,	PUNCT
fnp-4899	149	12	neurofibrillary	neurofibrillary	ADJ
fnp-4899	149	13	tangles	tangle	NOUN
fnp-4899	149	14	,	,	PUNCT
fnp-4899	149	15	and	and	CCONJ
fnp-4899	149	16	other	other	ADJ
fnp-4899	149	17	features	feature	NOUN
fnp-4899	149	18	for	for	ADP
fnp-4899	149	19	example	example	NOUN
fnp-4899	149	20	.	.	PUNCT
fnp-4899	150	1	these	these	DET
fnp-4899	150	2	models	model	NOUN
fnp-4899	150	3	work	work	VERB
fnp-4899	150	4	in	in	ADP
fnp-4899	150	5	a	a	DET
fnp-4899	150	6	supervised	supervised	ADJ
fnp-4899	150	7	fashion	fashion	NOUN
fnp-4899	150	8	,	,	PUNCT
fnp-4899	150	9	requiring	require	VERB
fnp-4899	150	10	large	large	ADJ
fnp-4899	150	11	numbers	number	NOUN
fnp-4899	150	12	of	of	ADP
fnp-4899	150	13	annotated	annotate	VERB
fnp-4899	150	14	images	image	NOUN
fnp-4899	150	15	for	for	ADP
fnp-4899	150	16	training	training	NOUN
fnp-4899	150	17	.	.	PUNCT
fnp-4899	151	1	this	this	PRON
fnp-4899	151	2	is	be	AUX
fnp-4899	151	3	highly	highly	ADV
fnp-4899	151	4	burdensome	burdensome	ADJ
fnp-4899	151	5	and	and	CCONJ
fnp-4899	151	6	acquiring	acquire	VERB
fnp-4899	151	7	this	this	DET
fnp-4899	151	8	ground	ground	NOUN
fnp-4899	151	9	truth	truth	NOUN
fnp-4899	151	10	for	for	ADP
fnp-4899	151	11	model	model	NOUN
fnp-4899	151	12	training	training	NOUN
fnp-4899	151	13	represents	represent	VERB
fnp-4899	151	14	a	a	DET
fnp-4899	151	15	major	major	ADJ
fnp-4899	151	16	barrier	barrier	NOUN
fnp-4899	151	17	.	.	PUNCT
fnp-4899	152	1	in	in	ADP
fnp-4899	152	2	a	a	DET
fnp-4899	152	3	study	study	NOUN
fnp-4899	152	4	by	by	ADP
fnp-4899	152	5	mckenzie	mckenzie	PROPN
fnp-4899	152	6	et	et	PROPN
fnp-4899	152	7	al	al	PROPN
fnp-4899	152	8	.	.	PROPN
fnp-4899	152	9	(	(	PUNCT
fnp-4899	152	10	led	lead	VERB
fnp-4899	152	11	by	by	ADP
fnp-4899	152	12	the	the	DET
fnp-4899	152	13	author	author	NOUN
fnp-4899	152	14	of	of	ADP
fnp-4899	152	15	this	this	DET
fnp-4899	152	16	review	review	NOUN
fnp-4899	152	17	)	)	PUNCT
fnp-4899	152	18	,	,	PUNCT
fnp-4899	152	19	investigators	investigator	NOUN
fnp-4899	152	20	applied	apply	VERB
fnp-4899	152	21	a	a	DET
fnp-4899	152	22	multiple	multiple	ADJ
fnp-4899	152	23	instance	instance	NOUN
fnp-4899	152	24	learning	learn	VERB
fnp-4899	152	25	model	model	NOUN
fnp-4899	152	26	to	to	ADP
fnp-4899	152	27	a	a	DET
fnp-4899	152	28	collection	collection	NOUN
fnp-4899	152	29	of	of	ADP
fnp-4899	152	30	whole	whole	ADJ
fnp-4899	152	31	slide	slide	NOUN
fnp-4899	152	32	images	image	NOUN
fnp-4899	152	33	from	from	ADP
fnp-4899	152	34	aged	aged	ADJ
fnp-4899	152	35	individuals	individual	NOUN
fnp-4899	152	36	in	in	ADP
fnp-4899	152	37	a	a	DET
fnp-4899	152	38	manuscript	manuscript	NOUN
fnp-4899	152	39	entitled	entitle	VERB
fnp-4899	152	40	“	"	PUNCT
fnp-4899	152	41	interpretable	interpretable	ADJ
fnp-4899	152	42	deep	deep	ADJ
fnp-4899	152	43	learning	learning	NOUN
fnp-4899	152	44	of	of	ADP
fnp-4899	152	45	myelin	myelin	NOUN
fnp-4899	152	46	histopathology	histopathology	NOUN
fnp-4899	152	47	in	in	ADP
fnp-4899	152	48	age	age	NOUN
fnp-4899	152	49	-	-	PUNCT
fnp-4899	152	50	related	relate	VERB
fnp-4899	152	51	cognitive	cognitive	ADJ
fnp-4899	152	52	impairment	impairment	NOUN
fnp-4899	152	53	”	"	PUNCT
fnp-4899	152	54	(	(	PUNCT
fnp-4899	152	55	mckenzie	mckenzie	NOUN
fnp-4899	152	56	et	et	PROPN
fnp-4899	152	57	al	al	PROPN
fnp-4899	152	58	.	.	PROPN
fnp-4899	152	59	,	,	PUNCT
fnp-4899	152	60	2022	2022	NUM
fnp-4899	152	61	)	)	PUNCT
fnp-4899	152	62	.	.	PUNCT
fnp-4899	153	1	this	this	DET
fnp-4899	153	2	model	model	NOUN
fnp-4899	153	3	uses	use	VERB
fnp-4899	153	4	slide	slide	NOUN
fnp-4899	153	5	level	level	NOUN
fnp-4899	153	6	labels	label	NOUN
fnp-4899	153	7	,	,	PUNCT
fnp-4899	153	8	rather	rather	ADV
fnp-4899	153	9	than	than	ADP
fnp-4899	153	10	annotations	annotation	NOUN
fnp-4899	153	11	on	on	ADP
fnp-4899	153	12	patches	patch	NOUN
fnp-4899	153	13	or	or	CCONJ
fnp-4899	153	14	pixel	pixel	ADJ
fnp-4899	153	15	level	level	NOUN
fnp-4899	153	16	segmentation	segmentation	NOUN
fnp-4899	153	17	of	of	ADP
fnp-4899	153	18	individual	individual	ADJ
fnp-4899	153	19	cells	cell	NOUN
fnp-4899	153	20	(	(	PUNCT
fnp-4899	153	21	figure	figure	NOUN
fnp-4899	153	22	8)	8)	NUM
fnp-4899	153	23	.	.	PUNCT
fnp-4899	154	1	the	the	DET
fnp-4899	154	2	investigators	investigator	NOUN
fnp-4899	154	3	found	find	VERB
fnp-4899	154	4	that	that	SCONJ
fnp-4899	154	5	the	the	DET
fnp-4899	154	6	ai	ai	NOUN
fnp-4899	154	7	was	be	AUX
fnp-4899	154	8	capable	capable	ADJ
fnp-4899	154	9	of	of	ADP
fnp-4899	154	10	predicting	predict	VERB
fnp-4899	154	11	cognitive	cognitive	ADJ
fnp-4899	154	12	impairment	impairment	NOUN
fnp-4899	154	13	based	base	VERB
fnp-4899	154	14	on	on	ADP
fnp-4899	154	15	a	a	DET
fnp-4899	154	16	luxol	luxol	NOUN
fnp-4899	154	17	-	-	PUNCT
fnp-4899	154	18	fast	fast	ADJ
fnp-4899	154	19	blue	blue	ADJ
fnp-4899	154	20	counterstained	counterstaine	VERB
fnp-4899	154	21	hematoxylin	hematoxylin	PROPN
fnp-4899	154	22	&	&	CCONJ
fnp-4899	154	23	eosin	eosin	PROPN
fnp-4899	154	24	-	-	PUNCT
fnp-4899	154	25	stained	stain	VERB
fnp-4899	154	26	section	section	NOUN
fnp-4899	154	27	alone	alone	ADV
fnp-4899	154	28	with	with	ADP
fnp-4899	154	29	an	an	DET
fnp-4899	154	30	accuracy	accuracy	NOUN
fnp-4899	154	31	of	of	ADP
fnp-4899	154	32	0.65	0.65	NUM
fnp-4899	154	33	.	.	PUNCT
fnp-4899	155	1	it	it	PRON
fnp-4899	155	2	should	should	AUX
fnp-4899	155	3	be	be	AUX
fnp-4899	155	4	noted	note	VERB
fnp-4899	155	5	that	that	SCONJ
fnp-4899	155	6	this	this	PRON
fnp-4899	155	7	is	be	AUX
fnp-4899	155	8	better	well	ADJ
fnp-4899	155	9	than	than	ADP
fnp-4899	155	10	chance	chance	NOUN
fnp-4899	155	11	and	and	CCONJ
fnp-4899	155	12	this	this	PRON
fnp-4899	155	13	is	be	AUX
fnp-4899	155	14	a	a	DET
fnp-4899	155	15	task	task	NOUN
fnp-4899	155	16	not	not	PART
fnp-4899	155	17	currently	currently	ADV
fnp-4899	155	18	possible	possible	ADJ
fnp-4899	155	19	by	by	ADP
fnp-4899	155	20	a	a	DET
fnp-4899	155	21	human	human	ADJ
fnp-4899	155	22	observer	observer	NOUN
fnp-4899	155	23	.	.	PUNCT
fnp-4899	156	1	further	further	ADJ
fnp-4899	156	2	analysis	analysis	NOUN
fnp-4899	156	3	of	of	ADP
fnp-4899	156	4	the	the	DET
fnp-4899	156	5	ai	ai	PROPN
fnp-4899	156	6	model	model	NOUN
fnp-4899	156	7	found	find	VERB
fnp-4899	156	8	highly	highly	ADV
fnp-4899	156	9	informative	informative	ADJ
fnp-4899	156	10	attention	attention	NOUN
fnp-4899	156	11	tiles	tile	NOUN
fnp-4899	156	12	,	,	PUNCT
fnp-4899	156	13	image	image	NOUN
fnp-4899	156	14	patches	patch	NOUN
fnp-4899	156	15	of	of	ADP
fnp-4899	156	16	the	the	DET
fnp-4899	156	17	whole	whole	ADJ
fnp-4899	156	18	slide	slide	NOUN
fnp-4899	156	19	image	image	NOUN
fnp-4899	156	20	that	that	PRON
fnp-4899	156	21	contain	contain	VERB
fnp-4899	156	22	the	the	DET
fnp-4899	156	23	most	most	ADV
fnp-4899	156	24	salient	salient	ADJ
fnp-4899	156	25	aspects	aspect	NOUN
fnp-4899	156	26	of	of	ADP
fnp-4899	156	27	the	the	DET
fnp-4899	156	28	slide	slide	NOUN
fnp-4899	156	29	,	,	PUNCT
fnp-4899	156	30	were	be	AUX
fnp-4899	156	31	concentrated	concentrate	VERB
fnp-4899	156	32	within	within	ADP
fnp-4899	156	33	white	white	ADJ
fnp-4899	156	34	matter	matter	NOUN
fnp-4899	156	35	regions	region	NOUN
fnp-4899	156	36	,	,	PUNCT
fnp-4899	156	37	not	not	PART
fnp-4899	156	38	gray	gray	ADJ
fnp-4899	156	39	matter	matter	NOUN
fnp-4899	156	40	that	that	PRON
fnp-4899	156	41	contains	contain	VERB
fnp-4899	156	42	well	well	ADV
fnp-4899	156	43	recognized	recognize	VERB
fnp-4899	156	44	structures	structure	NOUN
fnp-4899	156	45	including	include	VERB
fnp-4899	156	46	amyloid	amyloid	NOUN
fnp-4899	156	47	plaques	plaque	NOUN
fnp-4899	156	48	and	and	CCONJ
fnp-4899	156	49	tangles	tangle	NOUN
fnp-4899	156	50	that	that	PRON
fnp-4899	156	51	contribute	contribute	VERB
fnp-4899	156	52	to	to	ADP
fnp-4899	156	53	age	age	NOUN
fnp-4899	156	54	-	-	PUNCT
fnp-4899	156	55	related	relate	VERB
fnp-4899	156	56	impairment	impairment	NOUN
fnp-4899	156	57	.	.	PUNCT
fnp-4899	157	1	this	this	DET
fnp-4899	157	2	study	study	NOUN
fnp-4899	157	3	paves	pave	VERB
fnp-4899	157	4	the	the	DET
fnp-4899	157	5	way	way	NOUN
fnp-4899	157	6	towards	towards	ADP
fnp-4899	157	7	more	more	ADV
fnp-4899	157	8	advanced	advanced	ADJ
fnp-4899	157	9	models	model	NOUN
fnp-4899	157	10	for	for	ADP
fnp-4899	157	11	analyzing	analyze	VERB
fnp-4899	157	12	relevant	relevant	ADJ
fnp-4899	157	13	histological	histological	ADJ
fnp-4899	157	14	features	feature	NOUN
fnp-4899	157	15	of	of	ADP
fnp-4899	157	16	neurodegeneration	neurodegeneration	NOUN
fnp-4899	157	17	in	in	ADP
fnp-4899	157	18	human	human	ADJ
fnp-4899	157	19	autopsy	autopsy	ADJ
fnp-4899	157	20	brain	brain	NOUN
fnp-4899	157	21	tissues	tissue	NOUN
fnp-4899	157	22	.	.	PUNCT
fnp-4899	158	1	figure	figure	VERB
fnp-4899	158	2	8	8	NUM
fnp-4899	158	3	.	.	PUNCT
fnp-4899	159	1	multiple	multiple	ADJ
fnp-4899	159	2	instance	instance	NOUN
fnp-4899	159	3	learning	learn	VERB
fnp-4899	159	4	pipeline	pipeline	NOUN
fnp-4899	159	5	for	for	ADP
fnp-4899	159	6	whole	whole	ADJ
fnp-4899	159	7	slide	slide	NOUN
fnp-4899	159	8	image	image	NOUN
fnp-4899	159	9	analysis	analysis	NOUN
fnp-4899	159	10	.	.	PUNCT
fnp-4899	160	1	a.	a.	NOUN
fnp-4899	161	1	the	the	DET
fnp-4899	161	2	whole	whole	ADJ
fnp-4899	161	3	slide	slide	NOUN
fnp-4899	161	4	image	image	NOUN
fnp-4899	161	5	dataset	dataset	NOUN
fnp-4899	161	6	was	be	AUX
fnp-4899	161	7	derived	derive	VERB
fnp-4899	161	8	from	from	ADP
fnp-4899	161	9	aged	aged	ADJ
fnp-4899	161	10	human	human	ADJ
fnp-4899	161	11	brain	brain	NOUN
fnp-4899	161	12	donors	donor	NOUN
fnp-4899	161	13	.	.	PUNCT
fnp-4899	162	1	b.	b.	PROPN
fnp-4899	162	2	whole	whole	ADJ
fnp-4899	162	3	slide	slide	NOUN
fnp-4899	162	4	images	image	NOUN
fnp-4899	162	5	are	be	AUX
fnp-4899	162	6	segmented	segment	VERB
fnp-4899	162	7	into	into	ADP
fnp-4899	162	8	tiles	tile	NOUN
fnp-4899	162	9	and	and	CCONJ
fnp-4899	162	10	processed	process	VERB
fnp-4899	162	11	through	through	ADP
fnp-4899	162	12	a	a	DET
fnp-4899	162	13	multiple	multiple	ADJ
fnp-4899	162	14	instance	instance	NOUN
fnp-4899	162	15	learning	learn	VERB
fnp-4899	162	16	pipeline	pipeline	NOUN
fnp-4899	162	17	.	.	PUNCT
fnp-4899	163	1	c.	c.	NOUN
fnp-4899	163	2	attention	attention	NOUN
fnp-4899	163	3	values	value	NOUN
fnp-4899	163	4	are	be	AUX
fnp-4899	163	5	used	use	VERB
fnp-4899	163	6	to	to	PART
fnp-4899	163	7	map	map	VERB
fnp-4899	163	8	salient	salient	NOUN
fnp-4899	163	9	features	feature	NOUN
fnp-4899	163	10	.	.	PUNCT
fnp-4899	164	1	(	(	PUNCT
fnp-4899	164	2	reproduced	reproduce	VERB
fnp-4899	164	3	with	with	ADP
fnp-4899	164	4	permission	permission	NOUN
fnp-4899	164	5	under	under	ADP
fnp-4899	164	6	the	the	DET
fnp-4899	164	7	creative	creative	ADJ
fnp-4899	164	8	commons	common	NOUN
fnp-4899	164	9	license	license	NOUN
fnp-4899	164	10	from	from	ADP
fnp-4899	164	11	mckenzie	mckenzie	PROPN
fnp-4899	164	12	et	et	PROPN
fnp-4899	164	13	al	al	PROPN
fnp-4899	164	14	.	.	PROPN
fnp-4899	164	15	,	,	PUNCT
fnp-4899	164	16	2022	2022	NUM
fnp-4899	164	17	)	)	PUNCT
fnp-4899	164	18	.	.	PUNCT
fnp-4899	165	1	acknowledgements	acknowledgement	NOUN
fnp-4899	165	2	this	this	DET
fnp-4899	165	3	work	work	NOUN
fnp-4899	165	4	was	be	AUX
fnp-4899	165	5	supported	support	VERB
fnp-4899	165	6	by	by	ADP
fnp-4899	165	7	funding	funding	NOUN
fnp-4899	165	8	from	from	ADP
fnp-4899	165	9	the	the	DET
fnp-4899	165	10	nih	nih	PROPN
fnp-4899	165	11	(	(	PUNCT
fnp-4899	165	12	r01ag054008	r01ag054008	PROPN
fnp-4899	165	13	,	,	PUNCT
fnp-4899	165	14	r01ns095252	r01ns095252	NOUN
fnp-4899	165	15	,	,	PUNCT
fnp-4899	165	16	r01ag062348	r01ag062348	NOUN
fnp-4899	165	17	,	,	PUNCT
fnp-4899	165	18	r01ns086736	r01ns086736	NOUN
fnp-4899	165	19	,	,	PUNCT
fnp-4899	165	20	u54ns115266	u54ns115266	PROPN
fnp-4899	165	21	,	,	PUNCT
fnp-4899	165	22	u54ns115322	u54ns115322	NOUN
fnp-4899	165	23	)	)	PUNCT
fnp-4899	165	24	as	as	ADV
fnp-4899	165	25	well	well	ADV
fnp-4899	165	26	as	as	ADP
fnp-4899	165	27	the	the	DET
fnp-4899	165	28	rainwater	rainwater	NOUN
fnp-4899	165	29	charitable	charitable	PROPN
fnp-4899	165	30	trust	trust	PROPN
fnp-4899	165	31	/	/	SYM
fnp-4899	165	32	tau	tau	PROPN
fnp-4899	165	33	consortium	consortium	PROPN
fnp-4899	165	34	,	,	PUNCT
fnp-4899	165	35	a	a	DET
fnp-4899	165	36	alexander	alexander	PROPN
fnp-4899	165	37	saint	saint	PROPN
fnp-4899	165	38	amand	amand	PROPN
fnp-4899	165	39	scholar	scholar	PROPN
fnp-4899	165	40	award	award	PROPN
fnp-4899	165	41	,	,	PUNCT
fnp-4899	165	42	and	and	CCONJ
fnp-4899	165	43	a	a	DET
fnp-4899	165	44	karen	karen	PROPN
fnp-4899	165	45	strauss	strauss	PROPN
fnp-4899	165	46	cook	cook	PROPN
fnp-4899	165	47	research	research	NOUN
fnp-4899	165	48	scholar	scholar	NOUN
fnp-4899	165	49	award	award	NOUN
fnp-4899	165	50	.	.	PUNCT
fnp-4899	166	1	images	image	NOUN
fnp-4899	166	2	have	have	AUX
fnp-4899	166	3	been	be	AUX
fnp-4899	166	4	reproduced	reproduce	VERB
fnp-4899	166	5	under	under	ADP
fnp-4899	166	6	the	the	DET
fnp-4899	166	7	creative	creative	ADJ
fnp-4899	166	8	commons	common	NOUN
fnp-4899	166	9	license	license	NOUN
fnp-4899	166	10	:	:	PUNCT
fnp-4899	166	11	visit	visit	VERB
fnp-4899	166	12	http://creativecommons.org/licenses/by/4.0/.	http://creativecommons.org/licenses/by/4.0/.	NOUN
fnp-4899	166	13	references	reference	NOUN
fnp-4899	166	14	1	1	NUM
fnp-4899	166	15	.	.	PUNCT
fnp-4899	166	16	atherton	atherton	PROPN
fnp-4899	166	17	,	,	PUNCT
fnp-4899	166	18	k.	k.	PROPN
fnp-4899	166	19	,	,	PUNCT
fnp-4899	166	20	han	han	PROPN
fnp-4899	166	21	,	,	PUNCT
fnp-4899	166	22	x.	x.	PROPN
fnp-4899	166	23	,	,	PUNCT
fnp-4899	166	24	chung	chung	PROPN
fnp-4899	166	25	,	,	PUNCT
fnp-4899	166	26	j.	j.	PROPN
fnp-4899	166	27	,	,	PUNCT
fnp-4899	166	28	cherry	cherry	PROPN
fnp-4899	166	29	,	,	PUNCT
fnp-4899	166	30	j.	j.	PROPN
fnp-4899	166	31	d.	d.	PROPN
fnp-4899	166	32	,	,	PUNCT
fnp-4899	166	33	baucom	baucom	PROPN
fnp-4899	166	34	,	,	PUNCT
fnp-4899	166	35	z.	z.	PROPN
fnp-4899	166	36	,	,	PUNCT
fnp-4899	166	37	saltiel	saltiel	PROPN
fnp-4899	166	38	,	,	PUNCT
fnp-4899	166	39	n.	n.	NOUN
fnp-4899	166	40	,	,	PUNCT
fnp-4899	166	41	nair	nair	PROPN
fnp-4899	166	42	,	,	PUNCT
fnp-4899	166	43	e.	e.	PROPN
fnp-4899	166	44	,	,	PUNCT
fnp-4899	166	45	abdolmohammadi	abdolmohammadi	PROPN
fnp-4899	166	46	,	,	PUNCT
fnp-4899	166	47	b.	b.	PROPN
fnp-4899	166	48	,	,	PUNCT
fnp-4899	166	49	uretsky	uretsky	PROPN
fnp-4899	166	50	,	,	PUNCT
fnp-4899	166	51	m.	m.	NOUN
fnp-4899	166	52	,	,	PUNCT
fnp-4899	166	53	khan	khan	PROPN
fnp-4899	166	54	,	,	PUNCT
fnp-4899	166	55	m.	m.	NOUN
fnp-4899	166	56	m.	m.	NOUN
fnp-4899	166	57	,	,	PUNCT
fnp-4899	166	58	shea	shea	PROPN
fnp-4899	166	59	,	,	PUNCT
fnp-4899	166	60	c.	c.	PROPN
fnp-4899	166	61	,	,	PUNCT
fnp-4899	166	62	durape	durape	NOUN
fnp-4899	166	63	,	,	PUNCT
fnp-4899	166	64	s.	s.	PROPN
fnp-4899	166	65	,	,	PUNCT
fnp-4899	166	66	martin	martin	PROPN
fnp-4899	166	67	,	,	PUNCT
fnp-4899	166	68	b.	b.	PROPN
fnp-4899	166	69	m.	m.	PROPN
fnp-4899	166	70	,	,	PUNCT
fnp-4899	166	71	palmisano	palmisano	INTJ
fnp-4899	166	72	,	,	PUNCT
fnp-4899	166	73	j.	j.	PROPN
fnp-4899	166	74	n.	n.	PROPN
fnp-4899	166	75	,	,	PUNCT
fnp-4899	166	76	farrell	farrell	PROPN
fnp-4899	166	77	,	,	PUNCT
fnp-4899	166	78	k.	k.	PROPN
fnp-4899	166	79	,	,	PUNCT
fnp-4899	166	80	nowinski	nowinski	ADJ
fnp-4899	166	81	,	,	PUNCT
fnp-4899	166	82	c.	c.	PROPN
fnp-4899	166	83	j.	j.	PROPN
fnp-4899	166	84	,	,	PUNCT
fnp-4899	166	85	alvarez	alvarez	PROPN
fnp-4899	166	86	,	,	PUNCT
fnp-4899	166	87	v.	v.	PROPN
fnp-4899	166	88	e.	e.	PROPN
fnp-4899	166	89	,	,	PUNCT
fnp-4899	166	90	dwyer	dwyer	PROPN
fnp-4899	166	91	,	,	PUNCT
fnp-4899	166	92	b.	b.	PROPN
fnp-4899	166	93	,	,	PUNCT
fnp-4899	166	94	daneshvar	daneshvar	PROPN
fnp-4899	166	95	,	,	PUNCT
fnp-4899	166	96	d.	d.	PROPN
fnp-4899	166	97	h.	h.	PROPN
fnp-4899	166	98	,	,	PUNCT
fnp-4899	166	99	…	…	PUNCT
fnp-4899	166	100	mez	mez	PROPN
fnp-4899	166	101	,	,	PUNCT
fnp-4899	166	102	j.	j.	PROPN
fnp-4899	166	103	(	(	PUNCT
fnp-4899	166	104	2022	2022	NUM
fnp-4899	166	105	)	)	PUNCT
fnp-4899	166	106	.	.	PUNCT
fnp-4899	167	1	association	association	NOUN
fnp-4899	167	2	of	of	ADP
fnp-4899	167	3	apoe	apoe	ADJ
fnp-4899	167	4	genotypes	genotype	NOUN
fnp-4899	167	5	and	and	CCONJ
fnp-4899	167	6	chronic	chronic	ADJ
fnp-4899	167	7	traumatic	traumatic	ADJ
fnp-4899	167	8	encephalopathy	encephalopathy	NOUN
fnp-4899	167	9	.	.	PUNCT
fnp-4899	168	1	jama	jama	PROPN
fnp-4899	168	2	neurology	neurology	NOUN
fnp-4899	168	3	,	,	PUNCT
fnp-4899	168	4	79(8	79(8	NUM
fnp-4899	168	5	)	)	PUNCT
fnp-4899	168	6	,	,	PUNCT
fnp-4899	168	7	787–796	787–796	NUM
fnp-4899	168	8	.	.	PUNCT
fnp-4899	169	1	https://doi.org/10.1001/jamaneurol.2022.1634	https://doi.org/10.1001/jamaneurol.2022.1634	PROPN
fnp-4899	169	2	2	2	NUM
fnp-4899	169	3	.	.	PUNCT
fnp-4899	169	4	borghammer	borghammer	NOUN
fnp-4899	169	5	,	,	PUNCT
fnp-4899	169	6	p.	p.	PROPN
fnp-4899	169	7	,	,	PUNCT
fnp-4899	169	8	just	just	ADV
fnp-4899	169	9	,	,	PUNCT
fnp-4899	169	10	m.	m.	PROPN
fnp-4899	169	11	k.	k.	PROPN
fnp-4899	169	12	,	,	PUNCT
fnp-4899	169	13	horsager	horsager	PROPN
fnp-4899	169	14	,	,	PUNCT
fnp-4899	169	15	j.	j.	PROPN
fnp-4899	169	16	,	,	PUNCT
fnp-4899	169	17	skjærbæk	skjærbæk	PROPN
fnp-4899	169	18	,	,	PUNCT
fnp-4899	169	19	c.	c.	PROPN
fnp-4899	169	20	,	,	PUNCT
fnp-4899	169	21	raunio	raunio	PROPN
fnp-4899	169	22	,	,	PUNCT
fnp-4899	169	23	a.	a.	PROPN
fnp-4899	169	24	,	,	PUNCT
fnp-4899	169	25	kok	kok	PROPN
fnp-4899	169	26	,	,	PUNCT
fnp-4899	169	27	e.	e.	PROPN
fnp-4899	169	28	h.	h.	PROPN
fnp-4899	169	29	,	,	PUNCT
fnp-4899	169	30	savola	savola	PROPN
fnp-4899	169	31	,	,	PUNCT
fnp-4899	169	32	s.	s.	PROPN
fnp-4899	169	33	,	,	PUNCT
fnp-4899	169	34	murayama	murayama	PROPN
fnp-4899	169	35	,	,	PUNCT
fnp-4899	169	36	s.	s.	PROPN
fnp-4899	169	37	,	,	PUNCT
fnp-4899	169	38	saito	saito	PROPN
fnp-4899	169	39	,	,	PUNCT
fnp-4899	169	40	y.	y.	PROPN
fnp-4899	169	41	,	,	PUNCT
fnp-4899	169	42	myllykangas	myllykangas	PROPN
fnp-4899	169	43	,	,	PUNCT
fnp-4899	169	44	l.	l.	PROPN
fnp-4899	169	45	,	,	PUNCT
fnp-4899	169	46	&	&	CCONJ
fnp-4899	169	47	van	van	PROPN
fnp-4899	169	48	den	den	PROPN
fnp-4899	169	49	berge	berge	PROPN
fnp-4899	169	50	,	,	PUNCT
fnp-4899	169	51	n.	n.	NOUN
fnp-4899	169	52	(	(	PUNCT
fnp-4899	169	53	2022	2022	NUM
fnp-4899	169	54	)	)	PUNCT
fnp-4899	169	55	.	.	PUNCT
fnp-4899	170	1	a	a	DET
fnp-4899	170	2	postmortem	postmortem	NOUN
fnp-4899	170	3	study	study	NOUN
fnp-4899	170	4	suggests	suggest	VERB
fnp-4899	170	5	a	a	DET
fnp-4899	170	6	revision	revision	NOUN
fnp-4899	170	7	of	of	ADP
fnp-4899	170	8	the	the	DET
fnp-4899	170	9	dual	dual	ADV
fnp-4899	170	10	-	-	PUNCT
fnp-4899	170	11	hit	hit	VERB
fnp-4899	170	12	hypothesis	hypothesis	NOUN
fnp-4899	170	13	of	of	ADP
fnp-4899	170	14	parkinson	parkinson	NOUN
fnp-4899	170	15	’s	’s	PART
fnp-4899	170	16	disease	disease	NOUN
fnp-4899	170	17	.	.	PUNCT
fnp-4899	171	1	npj	npj	PROPN
fnp-4899	171	2	parkinson	parkinson	PROPN
fnp-4899	171	3	’s	’s	PART
fnp-4899	171	4	disease	disease	NOUN
fnp-4899	171	5	,	,	PUNCT
fnp-4899	171	6	8(1	8(1	NOUN
fnp-4899	171	7	)	)	PUNCT
fnp-4899	171	8	,	,	PUNCT
fnp-4899	171	9	166	166	NUM
fnp-4899	171	10	.	.	PUNCT
fnp-4899	171	11	https://doi.org/10.1038/s41531-022-00436-2	https://doi.org/10.1038/s41531-022-00436-2	NUM
fnp-4899	171	12	3	3	NUM
fnp-4899	171	13	.	.	X
fnp-4899	171	14	chang	chang	PROPN
fnp-4899	171	15	,	,	PUNCT
fnp-4899	171	16	a.	a.	PROPN
fnp-4899	171	17	,	,	PUNCT
fnp-4899	171	18	xiang	xiang	PROPN
fnp-4899	171	19	,	,	PUNCT
fnp-4899	171	20	x.	x.	PROPN
fnp-4899	171	21	,	,	PUNCT
fnp-4899	171	22	wang	wang	PROPN
fnp-4899	171	23	,	,	PUNCT
fnp-4899	171	24	j.	j.	PROPN
fnp-4899	171	25	,	,	PUNCT
fnp-4899	171	26	lee	lee	PROPN
fnp-4899	171	27	,	,	PUNCT
fnp-4899	171	28	c.	c.	PROPN
fnp-4899	171	29	,	,	PUNCT
fnp-4899	171	30	arakhamia	arakhamia	PROPN
fnp-4899	171	31	,	,	PUNCT
fnp-4899	171	32	t.	t.	PROPN
fnp-4899	171	33	,	,	PUNCT
fnp-4899	171	34	simjanoska	simjanoska	PROPN
fnp-4899	171	35	,	,	PUNCT
fnp-4899	171	36	m.	m.	NOUN
fnp-4899	171	37	,	,	PUNCT
fnp-4899	171	38	wang	wang	PROPN
fnp-4899	171	39	,	,	PUNCT
fnp-4899	171	40	c.	c.	PROPN
fnp-4899	171	41	,	,	PUNCT
fnp-4899	171	42	carlomagno	carlomagno	NOUN
fnp-4899	171	43	,	,	PUNCT
fnp-4899	171	44	y.	y.	PROPN
fnp-4899	171	45	,	,	PUNCT
fnp-4899	171	46	zhang	zhang	PROPN
fnp-4899	171	47	,	,	PUNCT
fnp-4899	171	48	g.	g.	PROPN
fnp-4899	171	49	,	,	PUNCT
fnp-4899	171	50	dhingra	dhingra	PROPN
fnp-4899	171	51	,	,	PUNCT
fnp-4899	171	52	s.	s.	PROPN
fnp-4899	171	53	,	,	PUNCT
fnp-4899	171	54	thierry	thierry	NOUN
fnp-4899	171	55	,	,	PUNCT
fnp-4899	171	56	m.	m.	NOUN
fnp-4899	171	57	,	,	PUNCT
fnp-4899	171	58	perneel	perneel	NOUN
fnp-4899	171	59	,	,	PUNCT
fnp-4899	171	60	j.	j.	PROPN
fnp-4899	171	61	,	,	PUNCT
fnp-4899	171	62	heeman	heeman	PROPN
fnp-4899	171	63	,	,	PUNCT
fnp-4899	171	64	b.	b.	PROPN
fnp-4899	171	65	,	,	PUNCT
fnp-4899	171	66	forgrave	forgrave	NOUN
fnp-4899	171	67	,	,	PUNCT
fnp-4899	171	68	l.	l.	PROPN
fnp-4899	171	69	m.	m.	PROPN
fnp-4899	171	70	,	,	PUNCT
fnp-4899	171	71	deture	deture	NOUN
fnp-4899	171	72	,	,	PUNCT
fnp-4899	171	73	m.	m.	NOUN
fnp-4899	171	74	,	,	PUNCT
fnp-4899	171	75	demarco	demarco	PROPN
fnp-4899	171	76	,	,	PUNCT
fnp-4899	171	77	m.	m.	PROPN
fnp-4899	171	78	l.	l.	PROPN
fnp-4899	171	79	,	,	PUNCT
fnp-4899	171	80	cook	cook	VERB
fnp-4899	171	81	,	,	PUNCT
fnp-4899	171	82	c.	c.	PROPN
fnp-4899	171	83	n.	n.	PROPN
fnp-4899	171	84	,	,	PUNCT
fnp-4899	171	85	rademakers	rademaker	NOUN
fnp-4899	171	86	,	,	PUNCT
fnp-4899	171	87	r.	r.	PROPN
fnp-4899	171	88	,	,	PUNCT
fnp-4899	171	89	dickson	dickson	PROPN
fnp-4899	171	90	,	,	PUNCT
fnp-4899	171	91	d.	d.	PROPN
fnp-4899	171	92	w.	w.	PROPN
fnp-4899	171	93	,	,	PUNCT
fnp-4899	171	94	…	…	PUNCT
fnp-4899	171	95	fitzpatrick	fitzpatrick	PROPN
fnp-4899	171	96	,	,	PUNCT
fnp-4899	171	97	a.	a.	PROPN
fnp-4899	171	98	w.	w.	PROPN
fnp-4899	171	99	p.	p.	PROPN
fnp-4899	171	100	(	(	PUNCT
fnp-4899	171	101	2022	2022	NUM
fnp-4899	171	102	)	)	PUNCT
fnp-4899	171	103	.	.	PUNCT
fnp-4899	172	1	homotypic	homotypic	ADJ
fnp-4899	172	2	fibrillization	fibrillization	NOUN
fnp-4899	172	3	of	of	ADP
fnp-4899	172	4	tmem106b	tmem106b	PROPN
fnp-4899	172	5	across	across	ADP
fnp-4899	172	6	diverse	diverse	ADJ
fnp-4899	172	7	neurodegenerative	neurodegenerative	ADJ
fnp-4899	172	8	diseases	disease	NOUN
fnp-4899	172	9	.	.	PUNCT
fnp-4899	173	1	cell	cell	NOUN
fnp-4899	173	2	,	,	PUNCT
fnp-4899	173	3	185(8	185(8	NUM
fnp-4899	173	4	)	)	PUNCT
fnp-4899	173	5	,	,	PUNCT
fnp-4899	173	6	1346	1346	NUM
fnp-4899	173	7	-	-	SYM
fnp-4899	173	8	1355.e15	1355.e15	NUM
fnp-4899	173	9	.	.	PUNCT
fnp-4899	174	1	https://doi.org/10.1016/j.cell.2022.02.026	https://doi.org/10.1016/j.cell.2022.02.026	PROPN
fnp-4899	174	2	4	4	NUM
fnp-4899	174	3	.	.	PUNCT
fnp-4899	174	4	hallinan	hallinan	PROPN
fnp-4899	174	5	,	,	PUNCT
fnp-4899	174	6	g.	g.	PROPN
fnp-4899	174	7	i.	i.	PROPN
fnp-4899	174	8	,	,	PUNCT
fnp-4899	174	9	ozcan	ozcan	PROPN
fnp-4899	174	10	,	,	PUNCT
fnp-4899	174	11	k.	k.	PROPN
fnp-4899	174	12	a.	a.	PROPN
fnp-4899	174	13	,	,	PUNCT
fnp-4899	174	14	hoq	hoq	VERB
fnp-4899	174	15	,	,	PUNCT
fnp-4899	174	16	m.	m.	PROPN
fnp-4899	174	17	r.	r.	PROPN
fnp-4899	174	18	,	,	PUNCT
fnp-4899	174	19	cracco	cracco	PROPN
fnp-4899	174	20	,	,	PUNCT
fnp-4899	174	21	l.	l.	PROPN
fnp-4899	174	22	,	,	PUNCT
fnp-4899	174	23	vago	vago	PROPN
fnp-4899	174	24	,	,	PUNCT
fnp-4899	174	25	f.	f.	PROPN
fnp-4899	174	26	s.	s.	PROPN
fnp-4899	174	27	,	,	PUNCT
fnp-4899	174	28	bharath	bharath	PROPN
fnp-4899	174	29	,	,	PUNCT
fnp-4899	174	30	s.	s.	PROPN
fnp-4899	174	31	r.	r.	PROPN
fnp-4899	174	32	,	,	PUNCT
fnp-4899	174	33	li	li	PROPN
fnp-4899	174	34	,	,	PUNCT
fnp-4899	174	35	d.	d.	PROPN
fnp-4899	174	36	,	,	PUNCT
fnp-4899	174	37	jacobsen	jacobsen	PROPN
fnp-4899	174	38	,	,	PUNCT
fnp-4899	174	39	m.	m.	NOUN
fnp-4899	174	40	,	,	PUNCT
fnp-4899	174	41	doud	doud	PROPN
fnp-4899	174	42	,	,	PUNCT
fnp-4899	174	43	e.	e.	PROPN
fnp-4899	174	44	h.	h.	PROPN
fnp-4899	174	45	,	,	PUNCT
fnp-4899	174	46	mosley	mosley	PROPN
fnp-4899	174	47	,	,	PUNCT
fnp-4899	174	48	a.	a.	PROPN
fnp-4899	174	49	l.	l.	PROPN
fnp-4899	174	50	,	,	PUNCT
fnp-4899	174	51	fernandez	fernandez	PROPN
fnp-4899	174	52	,	,	PUNCT
fnp-4899	174	53	a.	a.	NOUN
fnp-4899	174	54	,	,	PUNCT
fnp-4899	174	55	garringer	garringer	NOUN
fnp-4899	174	56	,	,	PUNCT
fnp-4899	174	57	h.	h.	PROPN
fnp-4899	174	58	j.	j.	PROPN
fnp-4899	174	59	,	,	PUNCT
fnp-4899	174	60	jiang	jiang	PROPN
fnp-4899	174	61	,	,	PUNCT
fnp-4899	174	62	w.	w.	PROPN
fnp-4899	174	63	,	,	PUNCT
fnp-4899	174	64	ghetti	ghetti	PROPN
fnp-4899	174	65	,	,	PUNCT
fnp-4899	174	66	b.	b.	PROPN
fnp-4899	174	67	,	,	PUNCT
fnp-4899	174	68	&	&	CCONJ
fnp-4899	174	69	vidal	vidal	PROPN
fnp-4899	174	70	,	,	PUNCT
fnp-4899	174	71	r.	r.	PROPN
fnp-4899	174	72	(	(	PUNCT
fnp-4899	174	73	2022	2022	NUM
fnp-4899	174	74	)	)	PUNCT
fnp-4899	174	75	.	.	PUNCT
fnp-4899	175	1	cryo	cryo	PROPN
fnp-4899	175	2	-	-	PUNCT
fnp-4899	175	3	em	em	PRON
fnp-4899	175	4	structures	structure	NOUN
fnp-4899	175	5	of	of	ADP
fnp-4899	175	6	prion	prion	NOUN
fnp-4899	175	7	protein	protein	NOUN
fnp-4899	175	8	filaments	filament	NOUN
fnp-4899	175	9	from	from	ADP
fnp-4899	175	10	gerstmann	gerstmann	NOUN
fnp-4899	175	11	-	-	PUNCT
fnp-4899	175	12	sträussler	sträussler	NOUN
fnp-4899	175	13	-	-	PUNCT
fnp-4899	175	14	scheinker	scheinker	NOUN
fnp-4899	175	15	disease	disease	NOUN
fnp-4899	175	16	.	.	PUNCT
fnp-4899	176	1	acta	acta	PROPN
fnp-4899	176	2	neuropathologica	neuropathologica	PROPN
fnp-4899	176	3	,	,	PUNCT
fnp-4899	176	4	144(3	144(3	NUM
fnp-4899	176	5	)	)	PUNCT
fnp-4899	176	6	,	,	PUNCT
fnp-4899	176	7	509–520	509–520	NUM
fnp-4899	176	8	.	.	PUNCT
fnp-4899	177	1	https://doi.org/10.1007/s00401-022-02461-0	https://doi.org/10.1007/s00401-022-02461-0	VERB
fnp-4899	177	2	5	5	NUM
fnp-4899	177	3	.	.	PUNCT
fnp-4899	177	4	jiang	jiang	PROPN
fnp-4899	177	5	,	,	PUNCT
fnp-4899	177	6	y.	y.	PROPN
fnp-4899	177	7	x.	x.	PROPN
fnp-4899	177	8	,	,	PUNCT
fnp-4899	177	9	cao	cao	PROPN
fnp-4899	177	10	,	,	PUNCT
fnp-4899	177	11	q.	q.	PROPN
fnp-4899	177	12	,	,	PUNCT
fnp-4899	177	13	sawaya	sawaya	PROPN
fnp-4899	177	14	,	,	PUNCT
fnp-4899	177	15	m.	m.	PROPN
fnp-4899	177	16	r.	r.	PROPN
fnp-4899	177	17	,	,	PUNCT
fnp-4899	177	18	abskharon	abskharon	NOUN
fnp-4899	177	19	,	,	PUNCT
fnp-4899	177	20	r.	r.	PROPN
fnp-4899	177	21	,	,	PUNCT
fnp-4899	177	22	ge	ge	PROPN
fnp-4899	177	23	,	,	PUNCT
fnp-4899	177	24	p.	p.	NOUN
fnp-4899	177	25	,	,	PUNCT
fnp-4899	177	26	deture	deture	NOUN
fnp-4899	177	27	,	,	PUNCT
fnp-4899	177	28	m.	m.	NOUN
fnp-4899	177	29	,	,	PUNCT
fnp-4899	177	30	dickson	dickson	PROPN
fnp-4899	177	31	,	,	PUNCT
fnp-4899	177	32	d.	d.	PROPN
fnp-4899	177	33	w.	w.	PROPN
fnp-4899	177	34	,	,	PUNCT
fnp-4899	177	35	fu	fu	PROPN
fnp-4899	177	36	,	,	PUNCT
fnp-4899	177	37	j.	j.	PROPN
fnp-4899	177	38	y.	y.	PROPN
fnp-4899	177	39	,	,	PUNCT
fnp-4899	177	40	ogorzalek	ogorzalek	VERB
fnp-4899	177	41	loo	loo	PROPN
fnp-4899	177	42	,	,	PUNCT
fnp-4899	177	43	r.	r.	PROPN
fnp-4899	177	44	r.	r.	PROPN
fnp-4899	177	45	,	,	PUNCT
fnp-4899	177	46	loo	loo	PROPN
fnp-4899	177	47	,	,	PUNCT
fnp-4899	177	48	j.	j.	PROPN
fnp-4899	177	49	a.	a.	PROPN
fnp-4899	177	50	,	,	PUNCT
fnp-4899	177	51	&	&	CCONJ
fnp-4899	177	52	eisenberg	eisenberg	PROPN
fnp-4899	177	53	,	,	PUNCT
fnp-4899	177	54	d.	d.	PROPN
fnp-4899	177	55	s.	s.	PROPN
fnp-4899	177	56	(	(	PUNCT
fnp-4899	177	57	2022	2022	NUM
fnp-4899	177	58	)	)	PUNCT
fnp-4899	177	59	.	.	PUNCT
fnp-4899	178	1	amyloid	amyloid	NOUN
fnp-4899	178	2	fibrils	fibril	NOUN
fnp-4899	178	3	in	in	ADP
fnp-4899	178	4	ftld	ftld	ADJ
fnp-4899	178	5	-	-	PUNCT
fnp-4899	178	6	tdp	tdp	NOUN
fnp-4899	178	7	are	be	AUX
fnp-4899	178	8	composed	compose	VERB
fnp-4899	178	9	of	of	ADP
fnp-4899	178	10	tmem106b	tmem106b	ADJ
fnp-4899	178	11	and	and	CCONJ
fnp-4899	178	12	not	not	PART
fnp-4899	178	13	tdp-43	tdp-43	PROPN
fnp-4899	178	14	.	.	PUNCT
fnp-4899	179	1	nature	nature	NOUN
fnp-4899	179	2	,	,	PUNCT
fnp-4899	179	3	605(7909	605(7909	NOUN
fnp-4899	179	4	)	)	PUNCT
fnp-4899	179	5	,	,	PUNCT
fnp-4899	179	6	304–309	304–309	NUM
fnp-4899	179	7	.	.	PUNCT
fnp-4899	180	1	https://doi.org/10.1038/s41586-022-04670-9	https://doi.org/10.1038/s41586-022-04670-9	NUM
fnp-4899	180	2	6	6	NUM
fnp-4899	180	3	.	.	PUNCT
fnp-4899	181	1	johnson	johnson	PROPN
fnp-4899	181	2	,	,	PUNCT
fnp-4899	181	3	e.	e.	PROPN
fnp-4899	181	4	c.	c.	PROPN
fnp-4899	181	5	b.	b.	PROPN
fnp-4899	181	6	,	,	PUNCT
fnp-4899	181	7	carter	carter	PROPN
fnp-4899	181	8	,	,	PUNCT
fnp-4899	181	9	e.	e.	PROPN
fnp-4899	181	10	k.	k.	PROPN
fnp-4899	181	11	,	,	PUNCT
fnp-4899	181	12	dammer	dammer	PROPN
fnp-4899	181	13	,	,	PUNCT
fnp-4899	181	14	e.	e.	PROPN
fnp-4899	181	15	b.	b.	PROPN
fnp-4899	181	16	,	,	PUNCT
fnp-4899	181	17	duong	duong	PROPN
fnp-4899	181	18	,	,	PUNCT
fnp-4899	181	19	d.	d.	PROPN
fnp-4899	181	20	m.	m.	NOUN
fnp-4899	181	21	,	,	PUNCT
fnp-4899	181	22	gerasimov	gerasimov	VERB
fnp-4899	181	23	,	,	PUNCT
fnp-4899	181	24	e.	e.	PROPN
fnp-4899	181	25	s.	s.	PROPN
fnp-4899	181	26	,	,	PUNCT
fnp-4899	181	27	liu	liu	PROPN
fnp-4899	181	28	,	,	PUNCT
fnp-4899	181	29	y.	y.	PROPN
fnp-4899	181	30	,	,	PUNCT
fnp-4899	181	31	liu	liu	PROPN
fnp-4899	181	32	,	,	PUNCT
fnp-4899	181	33	j.	j.	PROPN
fnp-4899	181	34	,	,	PUNCT
fnp-4899	181	35	betarbet	betarbet	PROPN
fnp-4899	181	36	,	,	PUNCT
fnp-4899	181	37	r.	r.	PROPN
fnp-4899	181	38	,	,	PUNCT
fnp-4899	181	39	ping	ping	PROPN
fnp-4899	181	40	,	,	PUNCT
fnp-4899	181	41	l.	l.	PROPN
fnp-4899	181	42	,	,	PUNCT
fnp-4899	181	43	yin	yin	PROPN
fnp-4899	181	44	,	,	PUNCT
fnp-4899	181	45	l.	l.	PROPN
fnp-4899	181	46	,	,	PUNCT
fnp-4899	181	47	serrano	serrano	PROPN
fnp-4899	181	48	,	,	PUNCT
fnp-4899	181	49	g.	g.	PROPN
fnp-4899	181	50	e.	e.	PROPN
fnp-4899	181	51	,	,	PUNCT
fnp-4899	181	52	beach	beach	PROPN
fnp-4899	181	53	,	,	PUNCT
fnp-4899	181	54	t.	t.	PROPN
fnp-4899	181	55	g.	g.	PROPN
fnp-4899	181	56	,	,	PUNCT
fnp-4899	181	57	peng	peng	PROPN
fnp-4899	181	58	,	,	PUNCT
fnp-4899	181	59	j.	j.	PROPN
fnp-4899	181	60	,	,	PUNCT
fnp-4899	181	61	de	de	X
fnp-4899	181	62	jager	jager	PROPN
fnp-4899	181	63	,	,	PUNCT
fnp-4899	181	64	p.	p.	PROPN
fnp-4899	181	65	l.	l.	PROPN
fnp-4899	181	66	,	,	PUNCT
fnp-4899	181	67	haroutunian	haroutunian	NOUN
fnp-4899	181	68	,	,	PUNCT
fnp-4899	181	69	v.	v.	PROPN
fnp-4899	181	70	,	,	PUNCT
fnp-4899	181	71	zhang	zhang	PROPN
fnp-4899	181	72	,	,	PUNCT
fnp-4899	181	73	b.	b.	PROPN
fnp-4899	181	74	,	,	PUNCT
fnp-4899	181	75	gaiteri	gaiteri	PROPN
fnp-4899	181	76	,	,	PUNCT
fnp-4899	181	77	c.	c.	PROPN
fnp-4899	181	78	,	,	PUNCT
fnp-4899	181	79	bennett	bennett	PROPN
fnp-4899	181	80	,	,	PUNCT
fnp-4899	181	81	d.	d.	PROPN
fnp-4899	181	82	a.	a.	PROPN
fnp-4899	181	83	,	,	PUNCT
fnp-4899	181	84	gearing	gearing	NOUN
fnp-4899	181	85	,	,	PUNCT
fnp-4899	181	86	m.	m.	NOUN
fnp-4899	181	87	,	,	PUNCT
fnp-4899	181	88	…	…	PUNCT
fnp-4899	181	89	seyfried	seyfried	ADJ
fnp-4899	181	90	,	,	PUNCT
fnp-4899	181	91	n.	n.	NOUN
fnp-4899	181	92	t.	t.	PROPN
fnp-4899	181	93	(	(	PUNCT
fnp-4899	181	94	2022	2022	NUM
fnp-4899	181	95	)	)	PUNCT
fnp-4899	181	96	.	.	PUNCT
fnp-4899	182	1	large	large	ADJ
fnp-4899	182	2	-	-	PUNCT
fnp-4899	182	3	scale	scale	NOUN
fnp-4899	182	4	deep	deep	ADJ
fnp-4899	182	5	multi	multi	ADJ
fnp-4899	182	6	-	-	ADJ
fnp-4899	182	7	layer	layer	ADJ
fnp-4899	182	8	analysis	analysis	NOUN
fnp-4899	182	9	of	of	ADP
fnp-4899	182	10	alzheimer	alzheimer	PROPN
fnp-4899	182	11	’s	’s	PART
fnp-4899	182	12	disease	disease	NOUN
fnp-4899	182	13	brain	brain	NOUN
fnp-4899	182	14	reveals	reveal	VERB
fnp-4899	182	15	strong	strong	ADJ
fnp-4899	182	16	proteomic	proteomic	ADJ
fnp-4899	182	17	disease	disease	NOUN
fnp-4899	182	18	-	-	PUNCT
fnp-4899	182	19	related	relate	VERB
fnp-4899	182	20	changes	change	NOUN
fnp-4899	182	21	not	not	PART
fnp-4899	182	22	observed	observe	VERB
fnp-4899	182	23	at	at	ADP
fnp-4899	182	24	the	the	DET
fnp-4899	182	25	rna	rna	NOUN
fnp-4899	182	26	level	level	NOUN
fnp-4899	182	27	.	.	PUNCT
fnp-4899	183	1	nature	nature	NOUN
fnp-4899	183	2	neuroscience	neuroscience	NOUN
fnp-4899	183	3	,	,	PUNCT
fnp-4899	183	4	25(2	25(2	NUM
fnp-4899	183	5	)	)	PUNCT
fnp-4899	183	6	,	,	PUNCT
fnp-4899	183	7	213–225	213–225	NUM
fnp-4899	183	8	.	.	PUNCT
fnp-4899	184	1	https://doi.org/10.1038/s41593-021-00999-y	https://doi.org/10.1038/s41593-021-00999-y	PROPN
fnp-4899	184	2	7	7	NUM
fnp-4899	184	3	.	.	PUNCT
fnp-4899	184	4	lopes	lopes	PROPN
fnp-4899	184	5	,	,	PUNCT
fnp-4899	184	6	k.	k.	PROPN
fnp-4899	184	7	de	de	PROPN
fnp-4899	184	8	p.	p.	PROPN
fnp-4899	184	9	,	,	PUNCT
fnp-4899	184	10	snijders	snijder	NOUN
fnp-4899	184	11	,	,	PUNCT
fnp-4899	184	12	g.	g.	PROPN
fnp-4899	184	13	j.	j.	PROPN
fnp-4899	184	14	l.	l.	PROPN
fnp-4899	184	15	,	,	PUNCT
fnp-4899	184	16	humphrey	humphrey	PROPN
fnp-4899	184	17	,	,	PUNCT
fnp-4899	184	18	j.	j.	PROPN
fnp-4899	184	19	,	,	PUNCT
fnp-4899	184	20	allan	allan	PROPN
fnp-4899	184	21	,	,	PUNCT
fnp-4899	184	22	a.	a.	PROPN
fnp-4899	184	23	,	,	PUNCT
fnp-4899	184	24	sneeboer	sneeboer	ADJ
fnp-4899	184	25	,	,	PUNCT
fnp-4899	184	26	m.	m.	NOUN
fnp-4899	184	27	a.	a.	NOUN
fnp-4899	184	28	m.	m.	PROPN
fnp-4899	184	29	,	,	PUNCT
fnp-4899	184	30	navarro	navarro	PROPN
fnp-4899	184	31	,	,	PUNCT
fnp-4899	184	32	e.	e.	PROPN
fnp-4899	184	33	,	,	PUNCT
fnp-4899	184	34	schilder	schilder	PROPN
fnp-4899	184	35	,	,	PUNCT
fnp-4899	184	36	b.	b.	PROPN
fnp-4899	184	37	m.	m.	PROPN
fnp-4899	184	38	,	,	PUNCT
fnp-4899	184	39	vialle	vialle	PROPN
fnp-4899	184	40	,	,	PUNCT
fnp-4899	184	41	r.	r.	PROPN
fnp-4899	184	42	a.	a.	PROPN
fnp-4899	184	43	,	,	PUNCT
fnp-4899	184	44	parks	park	NOUN
fnp-4899	184	45	,	,	PUNCT
fnp-4899	184	46	m.	m.	NOUN
fnp-4899	184	47	,	,	PUNCT
fnp-4899	184	48	missall	missall	PROPN
fnp-4899	184	49	,	,	PUNCT
fnp-4899	184	50	r.	r.	PROPN
fnp-4899	184	51	,	,	PUNCT
fnp-4899	184	52	van	van	PROPN
fnp-4899	184	53	zuiden	zuiden	PROPN
fnp-4899	184	54	,	,	PUNCT
fnp-4899	184	55	w.	w.	PROPN
fnp-4899	184	56	,	,	PUNCT
fnp-4899	184	57	gigase	gigase	PROPN
fnp-4899	184	58	,	,	PUNCT
fnp-4899	184	59	f.	f.	PROPN
fnp-4899	184	60	a.	a.	PROPN
fnp-4899	184	61	j.	j.	PROPN
fnp-4899	184	62	,	,	PUNCT
fnp-4899	184	63	kübler	kübler	PROPN
fnp-4899	184	64	,	,	PUNCT
fnp-4899	184	65	r.	r.	PROPN
fnp-4899	184	66	,	,	PUNCT
fnp-4899	184	67	van	van	PROPN
fnp-4899	184	68	berlekom	berlekom	PROPN
fnp-4899	184	69	,	,	PUNCT
fnp-4899	184	70	a.	a.	PROPN
fnp-4899	184	71	b.	b.	PROPN
fnp-4899	184	72	,	,	PUNCT
fnp-4899	184	73	hicks	hicks	PROPN
fnp-4899	184	74	,	,	PUNCT
fnp-4899	184	75	e.	e.	PROPN
fnp-4899	184	76	m.	m.	PROPN
fnp-4899	184	77	,	,	PUNCT
fnp-4899	184	78	bӧttcher	bӧttcher	PROPN
fnp-4899	184	79	,	,	PUNCT
fnp-4899	184	80	c.	c.	NOUN
fnp-4899	184	81	,	,	PUNCT
fnp-4899	184	82	priller	priller	NOUN
fnp-4899	184	83	,	,	PUNCT
fnp-4899	184	84	j.	j.	PROPN
fnp-4899	184	85	,	,	PUNCT
fnp-4899	184	86	kahn	kahn	PROPN
fnp-4899	184	87	,	,	PUNCT
fnp-4899	184	88	r.	r.	PROPN
fnp-4899	184	89	s.	s.	PROPN
fnp-4899	184	90	,	,	PUNCT
fnp-4899	184	91	de	de	PROPN
fnp-4899	184	92	witte	witte	PROPN
fnp-4899	184	93	,	,	PUNCT
fnp-4899	184	94	l.	l.	PROPN
fnp-4899	184	95	d.	d.	PROPN
fnp-4899	184	96	,	,	PUNCT
fnp-4899	184	97	&	&	CCONJ
fnp-4899	184	98	raj	raj	PROPN
fnp-4899	184	99	,	,	PUNCT
fnp-4899	184	100	t.	t.	PROPN
fnp-4899	184	101	(	(	PUNCT
fnp-4899	184	102	2022	2022	NUM
fnp-4899	184	103	)	)	PUNCT
fnp-4899	184	104	.	.	PUNCT
fnp-4899	185	1	genetic	genetic	ADJ
fnp-4899	185	2	analysis	analysis	NOUN
fnp-4899	185	3	of	of	ADP
fnp-4899	185	4	the	the	DET
fnp-4899	185	5	human	human	ADJ
fnp-4899	185	6	microglial	microglial	ADJ
fnp-4899	185	7	transcriptome	transcriptome	NOUN
fnp-4899	185	8	across	across	ADP
fnp-4899	185	9	brain	brain	NOUN
fnp-4899	185	10	regions	region	NOUN
fnp-4899	185	11	,	,	PUNCT
fnp-4899	185	12	aging	aging	NOUN
fnp-4899	185	13	and	and	CCONJ
fnp-4899	185	14	disease	disease	NOUN
fnp-4899	185	15	pathologies	pathology	NOUN
fnp-4899	185	16	.	.	PUNCT
fnp-4899	186	1	nature	nature	NOUN
fnp-4899	186	2	genetics	genetic	NOUN
fnp-4899	186	3	,	,	PUNCT
fnp-4899	186	4	54(1	54(1	NUM
fnp-4899	186	5	)	)	PUNCT
fnp-4899	186	6	,	,	PUNCT
fnp-4899	186	7	4–17	4–17	PROPN
fnp-4899	186	8	.	.	PUNCT
fnp-4899	187	1	https://doi.org/10.1038/s41588-021-00976-y	https://doi.org/10.1038/s41588-021-00976-y	NOUN
fnp-4899	187	2	8	8	NUM
fnp-4899	187	3	.	.	PUNCT
fnp-4899	187	4	ma	ma	PROPN
fnp-4899	187	5	,	,	PUNCT
fnp-4899	187	6	x.	x.	PROPN
fnp-4899	187	7	r.	r.	PROPN
fnp-4899	187	8	,	,	PUNCT
fnp-4899	187	9	prudencio	prudencio	PROPN
fnp-4899	187	10	,	,	PUNCT
fnp-4899	187	11	m.	m.	NOUN
fnp-4899	187	12	,	,	PUNCT
fnp-4899	187	13	koike	koike	NOUN
fnp-4899	187	14	,	,	PUNCT
fnp-4899	187	15	y.	y.	PROPN
fnp-4899	187	16	,	,	PUNCT
fnp-4899	187	17	vatsavayai	vatsavayai	PROPN
fnp-4899	187	18	,	,	PUNCT
fnp-4899	187	19	s.	s.	PROPN
fnp-4899	187	20	c.	c.	PROPN
fnp-4899	187	21	,	,	PUNCT
fnp-4899	187	22	kim	kim	PROPN
fnp-4899	187	23	,	,	PUNCT
fnp-4899	187	24	g.	g.	PROPN
fnp-4899	187	25	,	,	PUNCT
fnp-4899	187	26	harbinski	harbinski	PROPN
fnp-4899	187	27	,	,	PUNCT
fnp-4899	187	28	f.	f.	PROPN
fnp-4899	187	29	,	,	PUNCT
fnp-4899	187	30	briner	briner	NOUN
fnp-4899	187	31	,	,	PUNCT
fnp-4899	187	32	a.	a.	PROPN
fnp-4899	187	33	,	,	PUNCT
fnp-4899	187	34	rodriguez	rodriguez	PROPN
fnp-4899	187	35	,	,	PUNCT
fnp-4899	187	36	c.	c.	PROPN
fnp-4899	187	37	m.	m.	PROPN
fnp-4899	187	38	,	,	PUNCT
fnp-4899	187	39	guo	guo	PROPN
fnp-4899	187	40	,	,	PUNCT
fnp-4899	187	41	c.	c.	PROPN
fnp-4899	187	42	,	,	PUNCT
fnp-4899	187	43	akiyama	akiyama	PROPN
fnp-4899	187	44	,	,	PUNCT
fnp-4899	187	45	t.	t.	PROPN
fnp-4899	187	46	,	,	PUNCT
fnp-4899	187	47	schmidt	schmidt	PROPN
fnp-4899	187	48	,	,	PUNCT
fnp-4899	187	49	h.	h.	PROPN
fnp-4899	187	50	b.	b.	PROPN
fnp-4899	187	51	,	,	PUNCT
fnp-4899	187	52	cummings	cummings	PROPN
fnp-4899	187	53	,	,	PUNCT
fnp-4899	187	54	b.	b.	PROPN
fnp-4899	187	55	b.	b.	PROPN
fnp-4899	187	56	,	,	PUNCT
fnp-4899	187	57	wyatt	wyatt	PROPN
fnp-4899	187	58	,	,	PUNCT
fnp-4899	187	59	d.	d.	PROPN
fnp-4899	187	60	w.	w.	PROPN
fnp-4899	187	61	,	,	PUNCT
fnp-4899	187	62	kurylo	kurylo	PROPN
fnp-4899	187	63	,	,	PUNCT
fnp-4899	187	64	k.	k.	PROPN
fnp-4899	187	65	,	,	PUNCT
fnp-4899	187	66	miller	miller	PROPN
fnp-4899	187	67	,	,	PUNCT
fnp-4899	187	68	g.	g.	PROPN
fnp-4899	187	69	,	,	PUNCT
fnp-4899	187	70	mekhoubad	mekhoubad	PROPN
fnp-4899	187	71	,	,	PUNCT
fnp-4899	187	72	s.	s.	PROPN
fnp-4899	187	73	,	,	PUNCT
fnp-4899	187	74	sallee	sallee	ADJ
fnp-4899	187	75	,	,	PUNCT
fnp-4899	187	76	n.	n.	NOUN
fnp-4899	187	77	,	,	PUNCT
fnp-4899	187	78	mekonnen	mekonnen	PROPN
fnp-4899	187	79	,	,	PUNCT
fnp-4899	187	80	g.	g.	PROPN
fnp-4899	187	81	,	,	PUNCT
fnp-4899	187	82	ganser	ganser	PROPN
fnp-4899	187	83	,	,	PUNCT
fnp-4899	187	84	l.	l.	PROPN
fnp-4899	187	85	,	,	PUNCT
fnp-4899	187	86	…	…	PUNCT
fnp-4899	187	87	gitler	gitler	NOUN
fnp-4899	187	88	,	,	PUNCT
fnp-4899	187	89	a.	a.	PROPN
fnp-4899	187	90	d.	d.	PROPN
fnp-4899	187	91	(	(	PUNCT
fnp-4899	187	92	2022	2022	NUM
fnp-4899	187	93	)	)	PUNCT
fnp-4899	187	94	.	.	PUNCT
fnp-4899	188	1	tdp-43	tdp-43	PROPN
fnp-4899	188	2	represses	repress	VERB
fnp-4899	188	3	cryptic	cryptic	ADJ
fnp-4899	188	4	exon	exon	NOUN
fnp-4899	188	5	inclusion	inclusion	NOUN
fnp-4899	188	6	in	in	ADP
fnp-4899	188	7	the	the	DET
fnp-4899	188	8	ftd	ftd	NOUN
fnp-4899	188	9	-	-	PUNCT
fnp-4899	188	10	als	als	NOUN
fnp-4899	188	11	gene	gene	NOUN
fnp-4899	188	12	unc13a	unc13a	NOUN
fnp-4899	188	13	.	.	PUNCT
fnp-4899	189	1	nature	nature	NOUN
fnp-4899	189	2	,	,	PUNCT
fnp-4899	189	3	603(7899	603(7899	NOUN
fnp-4899	189	4	)	)	PUNCT
fnp-4899	189	5	,	,	PUNCT
fnp-4899	189	6	124–130	124–130	NUM
fnp-4899	189	7	.	.	PUNCT
fnp-4899	189	8	https://doi.org/10.1038/s41586-022-04424-7	https://doi.org/10.1038/s41586-022-04424-7	NUM
fnp-4899	189	9	9	9	NUM
fnp-4899	189	10	.	.	X
fnp-4899	189	11	mckenzie	mckenzie	PROPN
fnp-4899	189	12	,	,	PUNCT
fnp-4899	189	13	a.	a.	NOUN
fnp-4899	189	14	t.	t.	PROPN
fnp-4899	189	15	,	,	PUNCT
fnp-4899	189	16	marx	marx	PROPN
fnp-4899	189	17	,	,	PUNCT
fnp-4899	189	18	g.	g.	PROPN
fnp-4899	189	19	a.	a.	PROPN
fnp-4899	189	20	,	,	PUNCT
fnp-4899	189	21	koenigsberg	koenigsberg	PROPN
fnp-4899	189	22	,	,	PUNCT
fnp-4899	189	23	d.	d.	PROPN
fnp-4899	189	24	,	,	PUNCT
fnp-4899	189	25	sawyer	sawyer	PROPN
fnp-4899	189	26	,	,	PUNCT
fnp-4899	189	27	m.	m.	NOUN
fnp-4899	189	28	,	,	PUNCT
fnp-4899	189	29	iida	iida	PROPN
fnp-4899	189	30	,	,	PUNCT
fnp-4899	189	31	m.	m.	NOUN
fnp-4899	189	32	a.	a.	PROPN
fnp-4899	189	33	,	,	PUNCT
fnp-4899	189	34	walker	walker	PROPN
fnp-4899	189	35	,	,	PUNCT
fnp-4899	189	36	j.	j.	PROPN
fnp-4899	189	37	m.	m.	PROPN
fnp-4899	189	38	,	,	PUNCT
fnp-4899	189	39	richardson	richardson	PROPN
fnp-4899	189	40	,	,	PUNCT
fnp-4899	189	41	t.	t.	PROPN
fnp-4899	189	42	e.	e.	PROPN
fnp-4899	189	43	,	,	PUNCT
fnp-4899	189	44	campanella	campanella	PROPN
fnp-4899	189	45	,	,	PUNCT
fnp-4899	189	46	g.	g.	PROPN
fnp-4899	189	47	,	,	PUNCT
fnp-4899	189	48	attems	attem	VERB
fnp-4899	189	49	,	,	PUNCT
fnp-4899	189	50	j.	j.	PROPN
fnp-4899	189	51	,	,	PUNCT
fnp-4899	189	52	mckee	mckee	PROPN
fnp-4899	189	53	,	,	PUNCT
fnp-4899	189	54	a.	a.	PROPN
fnp-4899	189	55	c.	c.	PROPN
fnp-4899	189	56	,	,	PUNCT
fnp-4899	189	57	stein	stein	PROPN
fnp-4899	189	58	,	,	PUNCT
fnp-4899	189	59	t.	t.	PROPN
fnp-4899	189	60	d.	d.	PROPN
fnp-4899	189	61	,	,	PUNCT
fnp-4899	189	62	fuchs	fuchs	PROPN
fnp-4899	189	63	,	,	PUNCT
fnp-4899	189	64	t.	t.	PROPN
fnp-4899	189	65	j.	j.	PROPN
fnp-4899	189	66	,	,	PUNCT
fnp-4899	189	67	white	white	PROPN
fnp-4899	189	68	,	,	PUNCT
fnp-4899	189	69	c.	c.	PROPN
fnp-4899	189	70	l.	l.	PROPN
fnp-4899	189	71	,	,	PUNCT
fnp-4899	189	72	part	part	NOUN
fnp-4899	189	73	working	working	NOUN
fnp-4899	189	74	group	group	NOUN
fnp-4899	189	75	,	,	PUNCT
fnp-4899	189	76	farrell	farrell	PROPN
fnp-4899	189	77	,	,	PUNCT
fnp-4899	189	78	k.	k.	PROPN
fnp-4899	189	79	,	,	PUNCT
fnp-4899	189	80	&	&	CCONJ
fnp-4899	189	81	crary	crary	PROPN
fnp-4899	189	82	,	,	PUNCT
fnp-4899	189	83	j.	j.	PROPN
fnp-4899	189	84	f.	f.	PROPN
fnp-4899	189	85	(	(	PUNCT
fnp-4899	189	86	2022	2022	NUM
fnp-4899	189	87	)	)	PUNCT
fnp-4899	189	88	.	.	PUNCT
fnp-4899	190	1	interpretable	interpretable	ADJ
fnp-4899	190	2	deep	deep	ADJ
fnp-4899	190	3	learning	learning	NOUN
fnp-4899	190	4	of	of	ADP
fnp-4899	190	5	myelin	myelin	NOUN
fnp-4899	190	6	histopathology	histopathology	NOUN
fnp-4899	190	7	in	in	ADP
fnp-4899	190	8	age	age	NOUN
fnp-4899	190	9	-	-	PUNCT
fnp-4899	190	10	related	relate	VERB
fnp-4899	190	11	cognitive	cognitive	ADJ
fnp-4899	190	12	impairment	impairment	NOUN
fnp-4899	190	13	.	.	PUNCT
fnp-4899	191	1	acta	acta	PROPN
fnp-4899	191	2	neuropathologica	neuropathologica	PROPN
fnp-4899	191	3	communications	communications	PROPN
fnp-4899	191	4	,	,	PUNCT
fnp-4899	191	5	10(1	10(1	NUM
fnp-4899	191	6	)	)	PUNCT
fnp-4899	191	7	,	,	PUNCT
fnp-4899	191	8	131	131	NUM
fnp-4899	191	9	.	.	PUNCT
fnp-4899	191	10	https://doi.org/10.1186/s40478-022-01425-5	https://doi.org/10.1186/s40478-022-01425-5	NUM
fnp-4899	191	11	10	10	NUM
fnp-4899	191	12	.	.	PUNCT
fnp-4899	192	1	nelson	nelson	PROPN
fnp-4899	192	2	,	,	PUNCT
fnp-4899	192	3	p.	p.	PROPN
fnp-4899	192	4	t.	t.	PROPN
fnp-4899	192	5	,	,	PUNCT
fnp-4899	192	6	brayne	brayne	PROPN
fnp-4899	192	7	,	,	PUNCT
fnp-4899	192	8	c.	c.	PROPN
fnp-4899	192	9	,	,	PUNCT
fnp-4899	192	10	flanagan	flanagan	PROPN
fnp-4899	192	11	,	,	PUNCT
fnp-4899	192	12	m.	m.	PROPN
fnp-4899	192	13	e.	e.	PROPN
fnp-4899	192	14	,	,	PUNCT
fnp-4899	192	15	abner	abner	PROPN
fnp-4899	192	16	,	,	PUNCT
fnp-4899	192	17	e.	e.	PROPN
fnp-4899	192	18	l.	l.	PROPN
fnp-4899	192	19	,	,	PUNCT
fnp-4899	192	20	agrawal	agrawal	PROPN
fnp-4899	192	21	,	,	PUNCT
fnp-4899	192	22	s.	s.	PROPN
fnp-4899	192	23	,	,	PUNCT
fnp-4899	192	24	attems	attem	VERB
fnp-4899	192	25	,	,	PUNCT
fnp-4899	192	26	j.	j.	PROPN
fnp-4899	192	27	,	,	PUNCT
fnp-4899	192	28	castellani	castellani	PROPN
fnp-4899	192	29	,	,	PUNCT
fnp-4899	192	30	r.	r.	PROPN
fnp-4899	192	31	j.	j.	PROPN
fnp-4899	192	32	,	,	PUNCT
fnp-4899	192	33	corrada	corrada	PROPN
fnp-4899	192	34	,	,	PUNCT
fnp-4899	192	35	m.	m.	NOUN
fnp-4899	192	36	m.	m.	NOUN
fnp-4899	192	37	,	,	PUNCT
fnp-4899	192	38	cykowski	cykowski	NOUN
fnp-4899	192	39	,	,	PUNCT
fnp-4899	192	40	m.	m.	NOUN
fnp-4899	192	41	d.	d.	PROPN
fnp-4899	192	42	,	,	PUNCT
fnp-4899	192	43	di	di	PROPN
fnp-4899	192	44	,	,	PUNCT
fnp-4899	192	45	j.	j.	PROPN
fnp-4899	192	46	,	,	PUNCT
fnp-4899	192	47	dickson	dickson	PROPN
fnp-4899	192	48	,	,	PUNCT
fnp-4899	192	49	d.	d.	PROPN
fnp-4899	192	50	w.	w.	PROPN
fnp-4899	192	51	,	,	PUNCT
fnp-4899	192	52	dugger	dugger	PROPN
fnp-4899	192	53	,	,	PUNCT
fnp-4899	192	54	b.	b.	PROPN
fnp-4899	192	55	n.	n.	PROPN
fnp-4899	192	56	,	,	PUNCT
fnp-4899	192	57	ervin	ervin	PROPN
fnp-4899	192	58	,	,	PUNCT
fnp-4899	192	59	j.	j.	PROPN
fnp-4899	192	60	f.	f.	PROPN
fnp-4899	192	61	,	,	PUNCT
fnp-4899	192	62	fleming	fleming	PROPN
fnp-4899	192	63	,	,	PUNCT
fnp-4899	192	64	j.	j.	PROPN
fnp-4899	192	65	,	,	PUNCT
fnp-4899	192	66	graff	graff	PROPN
fnp-4899	192	67	-	-	PUNCT
fnp-4899	192	68	radford	radford	PROPN
fnp-4899	192	69	,	,	PUNCT
fnp-4899	192	70	j.	j.	PROPN
fnp-4899	192	71	,	,	PUNCT
fnp-4899	192	72	grinberg	grinberg	PROPN
fnp-4899	192	73	,	,	PUNCT
fnp-4899	192	74	l.	l.	PROPN
fnp-4899	192	75	t.	t.	PROPN
fnp-4899	192	76	,	,	PUNCT
fnp-4899	192	77	hokkanen	hokkanen	PROPN
fnp-4899	192	78	,	,	PUNCT
fnp-4899	192	79	s.	s.	PROPN
fnp-4899	192	80	r.	r.	PROPN
fnp-4899	192	81	k.	k.	PROPN
fnp-4899	192	82	,	,	PUNCT
fnp-4899	192	83	hunter	hunter	NOUN
fnp-4899	192	84	,	,	PUNCT
fnp-4899	192	85	s.	s.	PROPN
fnp-4899	192	86	,	,	PUNCT
fnp-4899	192	87	kapasi	kapasi	PROPN
fnp-4899	192	88	,	,	PUNCT
fnp-4899	192	89	a.	a.	PROPN
fnp-4899	192	90	,	,	PUNCT
fnp-4899	192	91	…	…	PUNCT
fnp-4899	192	92	schneider	schneider	NOUN
fnp-4899	192	93	,	,	PUNCT
fnp-4899	192	94	j.	j.	PROPN
fnp-4899	192	95	a.	a.	PROPN
fnp-4899	192	96	(	(	PUNCT
fnp-4899	192	97	2022	2022	NUM
fnp-4899	192	98	)	)	PUNCT
fnp-4899	192	99	.	.	PUNCT
fnp-4899	193	1	frequency	frequency	NOUN
fnp-4899	193	2	of	of	ADP
fnp-4899	193	3	late	late	ADJ
fnp-4899	193	4	neuropathologic	neuropathologic	ADJ
fnp-4899	193	5	change	change	NOUN
fnp-4899	193	6	across	across	ADP
fnp-4899	193	7	the	the	DET
fnp-4899	193	8	spectrum	spectrum	NOUN
fnp-4899	193	9	of	of	ADP
fnp-4899	193	10	alzheimer	alzheimer	PROPN
fnp-4899	193	11	’s	’s	PART
fnp-4899	193	12	disease	disease	NOUN
fnp-4899	193	13	neuropathology	neuropathology	NOUN
fnp-4899	193	14	:	:	PUNCT
fnp-4899	193	15	combined	combined	ADJ
fnp-4899	193	16	data	datum	NOUN
fnp-4899	193	17	from	from	ADP
fnp-4899	193	18	13	13	NUM
fnp-4899	193	19	community	community	NOUN
fnp-4899	193	20	-	-	PUNCT
fnp-4899	193	21	based	base	VERB
fnp-4899	193	22	or	or	CCONJ
fnp-4899	193	23	population	population	NOUN
fnp-4899	193	24	-	-	PUNCT
fnp-4899	193	25	based	base	VERB
fnp-4899	193	26	autopsy	autopsy	ADJ
fnp-4899	193	27	cohorts	cohort	NOUN
fnp-4899	193	28	.	.	PUNCT
fnp-4899	194	1	acta	acta	PROPN
fnp-4899	194	2	neuropathologica	neuropathologica	PROPN
fnp-4899	194	3	,	,	PUNCT
fnp-4899	194	4	144(1	144(1	NUM
fnp-4899	194	5	)	)	PUNCT
fnp-4899	194	6	,	,	PUNCT
fnp-4899	194	7	27–44	27–44	NUM
fnp-4899	194	8	.	.	NOUN
fnp-4899	194	9	https://doi.org/10.1007/s00401-022-02444-1	https://doi.org/10.1007/s00401-022-02444-1	NUM
fnp-4899	194	10	11	11	NUM
fnp-4899	194	11	.	.	PUNCT
fnp-4899	195	1	roemer	roemer	PROPN
fnp-4899	195	2	,	,	PUNCT
fnp-4899	195	3	s.	s.	PROPN
fnp-4899	195	4	f.	f.	PROPN
fnp-4899	195	5	,	,	PUNCT
fnp-4899	195	6	grinberg	grinberg	PROPN
fnp-4899	195	7	,	,	PUNCT
fnp-4899	195	8	l.	l.	PROPN
fnp-4899	195	9	t.	t.	PROPN
fnp-4899	195	10	,	,	PUNCT
fnp-4899	195	11	crary	crary	PROPN
fnp-4899	195	12	,	,	PUNCT
fnp-4899	195	13	j.	j.	PROPN
fnp-4899	195	14	f.	f.	PROPN
fnp-4899	195	15	,	,	PUNCT
fnp-4899	195	16	seeley	seeley	PROPN
fnp-4899	195	17	,	,	PUNCT
fnp-4899	195	18	w.	w.	PROPN
fnp-4899	195	19	w.	w.	PROPN
fnp-4899	195	20	,	,	PUNCT
fnp-4899	195	21	mckee	mckee	PROPN
fnp-4899	195	22	,	,	PUNCT
fnp-4899	195	23	a.	a.	PROPN
fnp-4899	195	24	c.	c.	PROPN
fnp-4899	195	25	,	,	PUNCT
fnp-4899	195	26	kovacs	kovacs	PROPN
fnp-4899	195	27	,	,	PUNCT
fnp-4899	195	28	g.	g.	PROPN
fnp-4899	195	29	g.	g.	PROPN
fnp-4899	195	30	,	,	PUNCT
fnp-4899	195	31	beach	beach	NOUN
fnp-4899	195	32	,	,	PUNCT
fnp-4899	195	33	t.	t.	PROPN
fnp-4899	195	34	g.	g.	PROPN
fnp-4899	195	35	,	,	PUNCT
fnp-4899	195	36	duyckaerts	duyckaert	NOUN
fnp-4899	195	37	,	,	PUNCT
fnp-4899	195	38	c.	c.	PROPN
fnp-4899	195	39	,	,	PUNCT
fnp-4899	195	40	ferrer	ferrer	PROPN
fnp-4899	195	41	,	,	PUNCT
fnp-4899	195	42	i.	i.	PROPN
fnp-4899	195	43	a.	a.	PROPN
fnp-4899	195	44	,	,	PUNCT
fnp-4899	195	45	gelpi	gelpi	NOUN
fnp-4899	195	46	,	,	PUNCT
fnp-4899	195	47	e.	e.	PROPN
fnp-4899	195	48	,	,	PUNCT
fnp-4899	195	49	lee	lee	PROPN
fnp-4899	195	50	,	,	PUNCT
fnp-4899	195	51	e.	e.	PROPN
fnp-4899	195	52	b.	b.	PROPN
fnp-4899	195	53	,	,	PUNCT
fnp-4899	195	54	revesz	revesz	ADJ
fnp-4899	195	55	,	,	PUNCT
fnp-4899	195	56	t.	t.	NOUN
fnp-4899	195	57	,	,	PUNCT
fnp-4899	195	58	white	white	ADJ
fnp-4899	195	59	,	,	PUNCT
fnp-4899	195	60	c.	c.	PROPN
fnp-4899	195	61	l.	l.	PROPN
fnp-4899	195	62	,	,	PUNCT
fnp-4899	195	63	yoshida	yoshida	PROPN
fnp-4899	195	64	,	,	PUNCT
fnp-4899	195	65	m.	m.	NOUN
fnp-4899	195	66	,	,	PUNCT
fnp-4899	195	67	pereira	pereira	PROPN
fnp-4899	195	68	,	,	PUNCT
fnp-4899	195	69	f.	f.	PROPN
fnp-4899	195	70	l.	l.	PROPN
fnp-4899	195	71	,	,	PUNCT
fnp-4899	195	72	whitney	whitney	PROPN
fnp-4899	195	73	,	,	PUNCT
fnp-4899	195	74	k.	k.	PROPN
fnp-4899	195	75	,	,	PUNCT
fnp-4899	195	76	ghayal	ghayal	NOUN
fnp-4899	195	77	,	,	PUNCT
fnp-4899	195	78	n.	n.	PROPN
fnp-4899	195	79	b.	b.	PROPN
fnp-4899	195	80	,	,	PUNCT
fnp-4899	195	81	&	&	CCONJ
fnp-4899	195	82	dickson	dickson	PROPN
fnp-4899	195	83	,	,	PUNCT
fnp-4899	195	84	d.	d.	PROPN
fnp-4899	195	85	w.	w.	PROPN
fnp-4899	195	86	(	(	PUNCT
fnp-4899	195	87	2022	2022	NUM
fnp-4899	195	88	)	)	PUNCT
fnp-4899	195	89	.	.	PUNCT
fnp-4899	196	1	rainwater	rainwater	NOUN
fnp-4899	196	2	charitable	charitable	ADJ
fnp-4899	196	3	foundation	foundation	NOUN
fnp-4899	196	4	criteria	criterion	NOUN
fnp-4899	196	5	for	for	ADP
fnp-4899	196	6	the	the	DET
fnp-4899	196	7	neuropathologic	neuropathologic	ADJ
fnp-4899	196	8	diagnosis	diagnosis	NOUN
fnp-4899	196	9	progressive	progressive	ADJ
fnp-4899	196	10	supranuclear	supranuclear	ADJ
fnp-4899	196	11	palsy	palsy	ADJ
fnp-4899	196	12	.	.	PUNCT
fnp-4899	197	1	acta	acta	PROPN
fnp-4899	197	2	neuropathologica,144(4	neuropathologica,144(4	PROPN
fnp-4899	197	3	)	)	PUNCT
fnp-4899	197	4	,	,	PUNCT
fnp-4899	198	1	603	603	NUM
fnp-4899	198	2	-	-	SYM
fnp-4899	198	3	614	614	NUM
fnp-4899	198	4	.	.	PUNCT
fnp-4899	198	5	https://doi.org/10.1007/s00401-022-02479-4	https://doi.org/10.1007/s00401-022-02479-4	NUM
fnp-4899	198	6	12	12	NUM
fnp-4899	198	7	.	.	PUNCT
fnp-4899	199	1	schweighauser	schweighauser	NOUN
fnp-4899	199	2	,	,	PUNCT
fnp-4899	199	3	m.	m.	NOUN
fnp-4899	199	4	,	,	PUNCT
fnp-4899	199	5	arseni	arseni	PROPN
fnp-4899	199	6	,	,	PUNCT
fnp-4899	199	7	d.	d.	PROPN
fnp-4899	199	8	,	,	PUNCT
fnp-4899	199	9	bacioglu	bacioglu	PROPN
fnp-4899	199	10	,	,	PUNCT
fnp-4899	199	11	m.	m.	NOUN
fnp-4899	199	12	,	,	PUNCT
fnp-4899	199	13	huang	huang	PROPN
fnp-4899	199	14	,	,	PUNCT
fnp-4899	199	15	m.	m.	NOUN
fnp-4899	199	16	,	,	PUNCT
fnp-4899	199	17	lövestam	lövestam	PROPN
fnp-4899	199	18	,	,	PUNCT
fnp-4899	199	19	s.	s.	PROPN
fnp-4899	199	20	,	,	PUNCT
fnp-4899	199	21	shi	shi	PROPN
fnp-4899	199	22	,	,	PUNCT
fnp-4899	199	23	y.	y.	PROPN
fnp-4899	199	24	,	,	PUNCT
fnp-4899	199	25	yang	yang	PROPN
fnp-4899	199	26	,	,	PUNCT
fnp-4899	199	27	y.	y.	PROPN
fnp-4899	199	28	,	,	PUNCT
fnp-4899	199	29	zhang	zhang	PROPN
fnp-4899	199	30	,	,	PUNCT
fnp-4899	199	31	w.	w.	PROPN
fnp-4899	199	32	,	,	PUNCT
fnp-4899	199	33	kotecha	kotecha	PROPN
fnp-4899	199	34	,	,	PUNCT
fnp-4899	199	35	a.	a.	NOUN
fnp-4899	199	36	,	,	PUNCT
fnp-4899	199	37	garringer	garringer	NOUN
fnp-4899	199	38	,	,	PUNCT
fnp-4899	199	39	h.	h.	PROPN
fnp-4899	199	40	j.	j.	PROPN
fnp-4899	199	41	,	,	PUNCT
fnp-4899	199	42	vidal	vidal	PROPN
fnp-4899	199	43	,	,	PUNCT
fnp-4899	199	44	r.	r.	PROPN
fnp-4899	199	45	,	,	PUNCT
fnp-4899	199	46	hallinan	hallinan	PROPN
fnp-4899	199	47	,	,	PUNCT
fnp-4899	199	48	g.	g.	PROPN
fnp-4899	199	49	i.	i.	PROPN
fnp-4899	199	50	,	,	PUNCT
fnp-4899	199	51	newell	newell	PROPN
fnp-4899	199	52	,	,	PUNCT
fnp-4899	199	53	k.	k.	PROPN
fnp-4899	199	54	l.	l.	PROPN
fnp-4899	199	55	,	,	PUNCT
fnp-4899	199	56	tarutani	tarutani	PROPN
fnp-4899	199	57	,	,	PUNCT
fnp-4899	199	58	a.	a.	NOUN
fnp-4899	199	59	,	,	PUNCT
fnp-4899	199	60	murayama	murayama	PROPN
fnp-4899	199	61	,	,	PUNCT
fnp-4899	199	62	s.	s.	PROPN
fnp-4899	199	63	,	,	PUNCT
fnp-4899	199	64	miyazaki	miyazaki	PROPN
fnp-4899	199	65	,	,	PUNCT
fnp-4899	199	66	m.	m.	NOUN
fnp-4899	199	67	,	,	PUNCT
fnp-4899	199	68	saito	saito	PROPN
fnp-4899	199	69	,	,	PUNCT
fnp-4899	199	70	y.	y.	PROPN
fnp-4899	199	71	,	,	PUNCT
fnp-4899	199	72	yoshida	yoshida	PROPN
fnp-4899	199	73	,	,	PUNCT
fnp-4899	199	74	m.	m.	NOUN
fnp-4899	199	75	,	,	PUNCT
fnp-4899	199	76	hasegawa	hasegawa	PROPN
fnp-4899	199	77	,	,	PUNCT
fnp-4899	199	78	k.	k.	PROPN
fnp-4899	199	79	,	,	PUNCT
fnp-4899	199	80	…	…	PUNCT
fnp-4899	199	81	scheres	schere	NOUN
fnp-4899	199	82	,	,	PUNCT
fnp-4899	199	83	s.	s.	PROPN
fnp-4899	199	84	h.	h.	PROPN
fnp-4899	199	85	w.	w.	PROPN
fnp-4899	199	86	(	(	PUNCT
fnp-4899	199	87	2022	2022	NUM
fnp-4899	199	88	)	)	PUNCT
fnp-4899	199	89	.	.	PUNCT
fnp-4899	200	1	age	age	NOUN
fnp-4899	200	2	-	-	PUNCT
fnp-4899	200	3	dependent	dependent	ADJ
fnp-4899	200	4	formation	formation	NOUN
fnp-4899	200	5	of	of	ADP
fnp-4899	200	6	tmem106b	tmem106b	ADJ
fnp-4899	200	7	amyloid	amyloid	NOUN
fnp-4899	200	8	filaments	filament	NOUN
fnp-4899	200	9	in	in	ADP
fnp-4899	200	10	human	human	ADJ
fnp-4899	200	11	brains	brain	NOUN
fnp-4899	200	12	.	.	PUNCT
fnp-4899	201	1	nature	nature	NOUN
fnp-4899	201	2	,	,	PUNCT
fnp-4899	201	3	605(7909	605(7909	NOUN
fnp-4899	201	4	)	)	PUNCT
fnp-4899	201	5	,	,	PUNCT
fnp-4899	201	6	310–314	310–314	NUM
fnp-4899	201	7	.	.	PUNCT
fnp-4899	202	1	https://doi.org/10.1038/s41586-022-04650-z	https://doi.org/10.1038/s41586-022-04650-z	NOUN
fnp-4899	202	2	copyright	copyright	NOUN
fnp-4899	202	3	:	:	PUNCT
fnp-4899	202	4	©	©	PROPN
fnp-4899	202	5	2023	2023	NUM
fnp-4899	202	6	the	the	DET
fnp-4899	202	7	author(s	author(s	NOUN
fnp-4899	202	8	)	)	PUNCT
fnp-4899	202	9	.	.	PUNCT
fnp-4899	203	1	this	this	PRON
fnp-4899	203	2	is	be	AUX
fnp-4899	203	3	an	an	DET
fnp-4899	203	4	open	open	ADJ
fnp-4899	203	5	access	access	NOUN
fnp-4899	203	6	article	article	NOUN
fnp-4899	203	7	distributed	distribute	VERB
fnp-4899	203	8	under	under	ADP
fnp-4899	203	9	the	the	DET
fnp-4899	203	10	terms	term	NOUN
fnp-4899	203	11	of	of	ADP
fnp-4899	203	12	the	the	DET
fnp-4899	203	13	creative	creative	ADJ
fnp-4899	203	14	commons	common	NOUN
fnp-4899	203	15	attribution	attribution	NOUN
fnp-4899	203	16	4.0	4.0	NUM
fnp-4899	203	17	international	international	ADJ
fnp-4899	203	18	license	license	NOUN
fnp-4899	203	19	(	(	PUNCT
fnp-4899	203	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-4899	203	21	)	)	PUNCT
fnp-4899	203	22	,	,	PUNCT
fnp-4899	203	23	which	which	PRON
fnp-4899	203	24	permits	permit	VERB
fnp-4899	203	25	unrestricted	unrestricted	ADJ
fnp-4899	203	26	use	use	NOUN
fnp-4899	203	27	,	,	PUNCT
fnp-4899	203	28	distribution	distribution	NOUN
fnp-4899	203	29	,	,	PUNCT
fnp-4899	203	30	and	and	CCONJ
fnp-4899	203	31	reproduction	reproduction	NOUN
fnp-4899	203	32	in	in	ADP
fnp-4899	203	33	any	any	DET
fnp-4899	203	34	medium	medium	NOUN
fnp-4899	203	35	,	,	PUNCT
fnp-4899	203	36	provided	provide	VERB
fnp-4899	203	37	the	the	DET
fnp-4899	203	38	original	original	ADJ
fnp-4899	203	39	author	author	NOUN
fnp-4899	203	40	and	and	CCONJ
fnp-4899	203	41	source	source	NOUN
fnp-4899	203	42	are	be	AUX
fnp-4899	203	43	credited	credit	VERB
fnp-4899	203	44	,	,	PUNCT
fnp-4899	203	45	a	a	DET
fnp-4899	203	46	link	link	NOUN
fnp-4899	203	47	to	to	ADP
fnp-4899	203	48	the	the	DET
fnp-4899	203	49	creative	creative	ADJ
fnp-4899	203	50	commons	common	NOUN
fnp-4899	203	51	license	license	NOUN
fnp-4899	203	52	is	be	AUX
fnp-4899	203	53	provided	provide	VERB
fnp-4899	203	54	,	,	PUNCT
fnp-4899	203	55	and	and	CCONJ
fnp-4899	203	56	any	any	DET
fnp-4899	203	57	changes	change	NOUN
fnp-4899	203	58	are	be	AUX
fnp-4899	203	59	indicated	indicate	VERB
fnp-4899	203	60	.	.	PUNCT
fnp-4899	204	1	the	the	DET
fnp-4899	204	2	creative	creative	ADJ
fnp-4899	204	3	commons	common	NOUN
fnp-4899	204	4	public	public	ADJ
fnp-4899	204	5	domain	domain	NOUN
fnp-4899	204	6	dedication	dedication	NOUN
fnp-4899	204	7	waiver	waiver	NOUN
fnp-4899	204	8	(	(	PUNCT
fnp-4899	204	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-4899	204	10	)	)	PUNCT
fnp-4899	204	11	applies	apply	VERB
fnp-4899	204	12	to	to	ADP
fnp-4899	204	13	the	the	DET
fnp-4899	204	14	data	datum	NOUN
fnp-4899	204	15	made	make	VERB
fnp-4899	204	16	available	available	ADJ
fnp-4899	204	17	in	in	ADP
fnp-4899	204	18	this	this	DET
fnp-4899	204	19	article	article	NOUN
fnp-4899	204	20	,	,	PUNCT
fnp-4899	204	21	unless	unless	SCONJ
fnp-4899	204	22	otherwise	otherwise	ADV
fnp-4899	204	23	stated	state	VERB
fnp-4899	204	24	.	.	PUNCT