id sid tid token lemma pos fnp-5195 1 1 63rd 63rd ADJ fnp-5195 1 2 annual annual ADJ fnp-5195 1 3 meeting meeting NOUN fnp-5195 1 4 of of ADP fnp-5195 1 5 the the DET fnp-5195 1 6 canadian canadian PROPN fnp-5195 1 7 association association PROPN fnp-5195 1 8 of of ADP fnp-5195 1 9 neuropathologists neuropathologists PROPN fnp-5195 1 10 association association PROPN fnp-5195 1 11 canadienne canadienne PROPN fnp-5195 1 12 des des PROPN fnp-5195 1 13 neuropathologistes neuropathologistes PROPN fnp-5195 1 14 ( ( PUNCT fnp-5195 1 15 canp canp NOUN fnp-5195 1 16 - - PUNCT fnp-5195 1 17 acnp acnp NOUN fnp-5195 1 18 ) ) PUNCT fnp-5195 1 19 feel feel VERB fnp-5195 1 20 free free ADJ fnp-5195 1 21 to to PART fnp-5195 1 22 add add VERB fnp-5195 1 23 comments comment NOUN fnp-5195 1 24 by by ADP fnp-5195 1 25 clicking click VERB fnp-5195 1 26 these these DET fnp-5195 1 27 icons icon NOUN fnp-5195 1 28 on on ADP fnp-5195 1 29 the the DET fnp-5195 1 30 sidebar sidebar NOUN fnp-5195 1 31 free free ADJ fnp-5195 1 32 neuropathology neuropathology NOUN fnp-5195 1 33 4:20 4:20 PROPN fnp-5195 1 34 ( ( PUNCT fnp-5195 1 35 2023 2023 NUM fnp-5195 1 36 ) ) PUNCT fnp-5195 1 37 meeting meeting NOUN fnp-5195 1 38 abstracts abstract VERB fnp-5195 1 39 63rd 63rd ADJ fnp-5195 1 40 annual annual ADJ fnp-5195 1 41 meeting meeting NOUN fnp-5195 1 42 of of ADP fnp-5195 1 43 the the DET fnp-5195 1 44 canadian canadian PROPN fnp-5195 1 45 association association PROPN fnp-5195 1 46 of of ADP fnp-5195 1 47 neuropathologists neuropathologists PROPN fnp-5195 1 48 association association PROPN fnp-5195 1 49 canadienne canadienne PROPN fnp-5195 1 50 des des PROPN fnp-5195 1 51 neuropathologistes neuropathologistes PROPN fnp-5195 1 52 ( ( PUNCT fnp-5195 1 53 canp canp NOUN fnp-5195 1 54 - - PUNCT fnp-5195 1 55 acnp acnp NOUN fnp-5195 1 56 ) ) PUNCT fnp-5195 1 57 meeting meeting NOUN fnp-5195 1 58 abstracts abstract VERB fnp-5195 1 59 october october PROPN fnp-5195 1 60 18th–21st 18th–21st NUM fnp-5195 1 61 , , PUNCT fnp-5195 1 62 2023 2023 NUM fnp-5195 1 63 montreal montreal PROPN fnp-5195 1 64 , , PUNCT fnp-5195 1 65 qc qc PROPN fnp-5195 1 66 submitted submit VERB fnp-5195 1 67 : : PUNCT fnp-5195 1 68 14 14 NUM fnp-5195 1 69 november november PROPN fnp-5195 1 70 2023 2023 NUM fnp-5195 1 71 accepted accept VERB fnp-5195 1 72 : : PUNCT fnp-5195 1 73 15 15 NUM fnp-5195 1 74 november november PROPN fnp-5195 1 75 2023 2023 NUM fnp-5195 1 76 published publish VERB fnp-5195 1 77 : : PUNCT fnp-5195 1 78 20 20 NUM fnp-5195 1 79 november november PROPN fnp-5195 1 80 2023 2023 NUM fnp-5195 1 81     SPACE fnp-5195 1 82 the the DET fnp-5195 1 83 canadian canadian PROPN fnp-5195 1 84 association association NOUN fnp-5195 1 85 of of ADP fnp-5195 1 86 neuropathologists neuropathologist NOUN fnp-5195 1 87 – – PUNCT fnp-5195 1 88 association association PROPN fnp-5195 1 89 canadienne canadienne PROPN fnp-5195 1 90 des des X fnp-5195 1 91 neuropathologistes neuropathologistes PROPN fnp-5195 1 92 ( ( PUNCT fnp-5195 1 93 canp canp NOUN fnp-5195 1 94 - - PUNCT fnp-5195 1 95 acnp acnp NOUN fnp-5195 1 96 ) ) PUNCT fnp-5195 1 97 held hold VERB fnp-5195 1 98 their their PRON fnp-5195 1 99 63rd 63rd ADJ fnp-5195 1 100 annual annual ADJ fnp-5195 1 101 meeting meeting NOUN fnp-5195 1 102 at at ADP fnp-5195 1 103 the the DET fnp-5195 1 104 mcgill mcgill PROPN fnp-5195 1 105 faculty faculty NOUN fnp-5195 1 106 club club NOUN fnp-5195 1 107 and and CCONJ fnp-5195 1 108 the the DET fnp-5195 1 109 montreal montreal PROPN fnp-5195 1 110 neurological neurological PROPN fnp-5195 1 111 institute institute PROPN fnp-5195 1 112 in in ADP fnp-5195 1 113 montreal montreal PROPN fnp-5195 1 114 , , PUNCT fnp-5195 1 115 qc qc PROPN fnp-5195 1 116 , , PUNCT fnp-5195 1 117 from from ADP fnp-5195 1 118 october october PROPN fnp-5195 1 119 18th 18th NOUN fnp-5195 1 120 to to ADP fnp-5195 1 121 21st 21st NOUN fnp-5195 1 122 , , PUNCT fnp-5195 1 123 2023 2023 NUM fnp-5195 1 124 , , PUNCT fnp-5195 1 125 under under ADP fnp-5195 1 126 the the DET fnp-5195 1 127 leadership leadership NOUN fnp-5195 1 128 of of ADP fnp-5195 1 129 dr dr PROPN fnp-5195 1 130 . . PROPN fnp-5195 1 131 robert robert PROPN fnp-5195 1 132 hammond hammond PROPN fnp-5195 1 133 , , PUNCT fnp-5195 1 134 president president NOUN fnp-5195 1 135 of of ADP fnp-5195 1 136 the the DET fnp-5195 1 137 canp canp NOUN fnp-5195 1 138 - - PUNCT fnp-5195 1 139 acnp acnp ADJ fnp-5195 1 140 , , PUNCT fnp-5195 1 141 dr dr PROPN fnp-5195 1 142 . . PROPN fnp-5195 1 143 peter peter PROPN fnp-5195 1 144 schutz schutz PROPN fnp-5195 1 145 , , PUNCT fnp-5195 1 146 secretary secretary NOUN fnp-5195 1 147 treasurer treasurer NOUN fnp-5195 1 148 of of ADP fnp-5195 1 149 the the DET fnp-5195 1 150 canp canp NOUN fnp-5195 1 151 - - PUNCT fnp-5195 1 152 acnp acnp NOUN fnp-5195 1 153 , , PUNCT fnp-5195 1 154 and and CCONJ fnp-5195 1 155 with with ADP fnp-5195 1 156 technical technical ADJ fnp-5195 1 157 support support NOUN fnp-5195 1 158 from from ADP fnp-5195 1 159 canp canp ADJ fnp-5195 1 160 administrator administrator NOUN fnp-5195 1 161 colleen colleen PROPN fnp-5195 1 162 fifield fifield PROPN fnp-5195 1 163 . . PUNCT fnp-5195 2 1 the the DET fnp-5195 2 2 academic academic ADJ fnp-5195 2 3 program program NOUN fnp-5195 2 4 comprised comprise VERB fnp-5195 2 5 18 18 NUM fnp-5195 2 6 scientific scientific ADJ fnp-5195 2 7 abstracts abstract NOUN fnp-5195 2 8 , , PUNCT fnp-5195 2 9 14 14 NUM fnp-5195 2 10 unknown unknown ADJ fnp-5195 2 11 cases case NOUN fnp-5195 2 12 , , PUNCT fnp-5195 2 13 a a DET fnp-5195 2 14 mini mini NOUN fnp-5195 2 15 - - NOUN fnp-5195 2 16 symposium symposium NOUN fnp-5195 2 17 on on ADP fnp-5195 2 18 molecular molecular ADJ fnp-5195 2 19 testing testing NOUN fnp-5195 2 20 of of ADP fnp-5195 2 21 brain brain NOUN fnp-5195 2 22 tumours tumour NOUN fnp-5195 2 23 in in ADP fnp-5195 2 24 canada canada PROPN fnp-5195 2 25 , , PUNCT fnp-5195 2 26 and and CCONJ fnp-5195 2 27 the the DET fnp-5195 2 28 presidential presidential ADJ fnp-5195 2 29 symposium symposium NOUN fnp-5195 2 30 on on ADP fnp-5195 2 31 pediatric pediatric ADJ fnp-5195 2 32 neuropathology neuropathology NOUN fnp-5195 2 33 . . PUNCT fnp-5195 3 1 digital digital ADJ fnp-5195 3 2 pathology pathology NOUN fnp-5195 3 3 images image VERB fnp-5195 3 4 from from ADP fnp-5195 3 5 the the DET fnp-5195 3 6 14 14 NUM fnp-5195 3 7 unknown unknown ADJ fnp-5195 3 8 cases case NOUN fnp-5195 3 9 are be AUX fnp-5195 3 10 available available ADJ fnp-5195 3 11 for for ADP fnp-5195 3 12 viewing view VERB fnp-5195 3 13 online online ADV fnp-5195 3 14 ( ( PUNCT fnp-5195 3 15 www.canp.ca www.canp.ca NOUN fnp-5195 3 16 ) ) PUNCT fnp-5195 3 17 . . PUNCT fnp-5195 4 1 the the DET fnp-5195 4 2 unknown unknown ADJ fnp-5195 4 3 case case NOUN fnp-5195 4 4 sessions session NOUN fnp-5195 4 5 were be AUX fnp-5195 4 6 moderated moderate VERB fnp-5195 4 7 by by ADP fnp-5195 4 8 dr dr PROPN fnp-5195 4 9 . . PROPN fnp-5195 4 10 peter peter PROPN fnp-5195 4 11 schutz schutz PROPN fnp-5195 4 12 . . PUNCT fnp-5195 5 1 the the DET fnp-5195 5 2 presidential presidential ADJ fnp-5195 5 3 symposium symposium NOUN fnp-5195 5 4 2023 2023 NUM fnp-5195 5 5 on on ADP fnp-5195 5 6 pediatric pediatric ADJ fnp-5195 5 7 neuropathology neuropathology NOUN fnp-5195 5 8 featured feature VERB fnp-5195 5 9 the the DET fnp-5195 5 10 gordon gordon PROPN fnp-5195 5 11 mathieson mathieson PROPN fnp-5195 5 12 lecture lecture NOUN fnp-5195 5 13 given give VERB fnp-5195 5 14 by by ADP fnp-5195 5 15 dr dr PROPN fnp-5195 5 16 . . PROPN fnp-5195 5 17 m. m. PROPN fnp-5195 5 18 del del PROPN fnp-5195 5 19 bigio bigio NOUN fnp-5195 5 20 on on ADP fnp-5195 5 21 in in ADP fnp-5195 5 22 - - PUNCT fnp-5195 5 23 utero utero ADJ fnp-5195 5 24 infections infection NOUN fnp-5195 5 25 and and CCONJ fnp-5195 5 26 their their PRON fnp-5195 5 27 effects effect NOUN fnp-5195 5 28 on on ADP fnp-5195 5 29 the the DET fnp-5195 5 30 developing develop VERB fnp-5195 5 31 brain brain NOUN fnp-5195 5 32 , , PUNCT fnp-5195 5 33 and and CCONJ fnp-5195 5 34 the the DET fnp-5195 5 35 david david PROPN fnp-5195 5 36 robertson robertson PROPN fnp-5195 5 37 lecture lecture NOUN fnp-5195 5 38 given give VERB fnp-5195 5 39 by by ADP fnp-5195 5 40 dr dr PROPN fnp-5195 5 41 . . PROPN fnp-5195 5 42 d. d. PROPN fnp-5195 5 43 van van PROPN fnp-5195 5 44 essen essen PROPN fnp-5195 5 45 entitled entitle VERB fnp-5195 5 46 models model NOUN fnp-5195 5 47 and and CCONJ fnp-5195 5 48 mechanisms mechanism NOUN fnp-5195 5 49 of of ADP fnp-5195 5 50 cerebral cerebral ADJ fnp-5195 5 51 cortical cortical ADJ fnp-5195 5 52 expansion expansion NOUN fnp-5195 5 53 and and CCONJ fnp-5195 5 54 folding folding NOUN fnp-5195 5 55 . . PUNCT fnp-5195 6 1 the the DET fnp-5195 6 2 program program NOUN fnp-5195 6 3 was be AUX fnp-5195 6 4 completed complete VERB fnp-5195 6 5 by by ADP fnp-5195 6 6 three three NUM fnp-5195 6 7 invited invite VERB fnp-5195 6 8 presentations presentation NOUN fnp-5195 6 9 with with ADP fnp-5195 6 10 dr dr PROPN fnp-5195 6 11 . . PROPN fnp-5195 6 12 m. m. PROPN fnp-5195 6 13 oskoui oskoui PROPN fnp-5195 6 14 presenting present VERB fnp-5195 6 15 on on ADP fnp-5195 6 16 the the DET fnp-5195 6 17 epidemiology epidemiology NOUN fnp-5195 6 18 of of ADP fnp-5195 6 19 cerebral cerebral ADJ fnp-5195 6 20 palsy palsy NOUN fnp-5195 6 21 in in ADP fnp-5195 6 22 canada canada PROPN fnp-5195 6 23 , , PUNCT fnp-5195 6 24 dr dr PROPN fnp-5195 6 25 . . PROPN fnp-5195 6 26 p. p. PROPN fnp-5195 6 27 ballabh ballabh PROPN fnp-5195 6 28 presenting present VERB fnp-5195 6 29 on on ADP fnp-5195 6 30 cerebral cerebral ADJ fnp-5195 6 31 gray gray ADJ fnp-5195 6 32 matter matter NOUN fnp-5195 6 33 injuries injury NOUN fnp-5195 6 34 in in ADP fnp-5195 6 35 infants infant NOUN fnp-5195 6 36 with with ADP fnp-5195 6 37 intraventricular intraventricular ADJ fnp-5195 6 38 hemorrhage hemorrhage NOUN fnp-5195 6 39 , , PUNCT fnp-5195 6 40 and and CCONJ fnp-5195 6 41 dr dr PROPN fnp-5195 6 42 . . PROPN fnp-5195 6 43 w. w. PROPN fnp-5195 6 44 foulkes foulkes PROPN fnp-5195 6 45 presenting present VERB fnp-5195 6 46 on on ADP fnp-5195 6 47 cns cns PROPN fnp-5195 6 48 manifestations manifestation NOUN fnp-5195 6 49 of of ADP fnp-5195 6 50 dicer-1 dicer-1 VERB fnp-5195 6 51 tumour tumour ADJ fnp-5195 6 52 predisposition predisposition NOUN fnp-5195 6 53 syndrome syndrome NOUN fnp-5195 6 54 . . PUNCT fnp-5195 7 1 the the DET fnp-5195 7 2 mary mary PROPN fnp-5195 7 3 tom tom PROPN fnp-5195 7 4 award award PROPN fnp-5195 7 5 for for ADP fnp-5195 7 6 best good ADJ fnp-5195 7 7 clinical clinical ADJ fnp-5195 7 8 science science NOUN fnp-5195 7 9 presentation presentation NOUN fnp-5195 7 10 by by ADP fnp-5195 7 11 a a DET fnp-5195 7 12 trainee trainee NOUN fnp-5195 7 13 went go VERB fnp-5195 7 14 to to ADP fnp-5195 7 15 dr dr PROPN fnp-5195 7 16 . . PROPN fnp-5195 7 17 k. k. PROPN fnp-5195 8 1 c. c. PROPN fnp-5195 8 2 martin martin PROPN fnp-5195 8 3 ( ( PUNCT fnp-5195 8 4 supervisor supervisor NOUN fnp-5195 8 5 dr dr PROPN fnp-5195 8 6 . . PROPN fnp-5195 8 7 s. s. PROPN fnp-5195 8 8 yip yip PROPN fnp-5195 8 9 ) ) PUNCT fnp-5195 8 10 , , PUNCT fnp-5195 8 11 and and CCONJ fnp-5195 8 12 the the DET fnp-5195 8 13 morrison morrison PROPN fnp-5195 8 14 h. h. PROPN fnp-5195 8 15 finlayson finlayson PROPN fnp-5195 8 16 award award PROPN fnp-5195 8 17 for for ADP fnp-5195 8 18 best good ADJ fnp-5195 8 19 basic basic ADJ fnp-5195 8 20 science science NOUN fnp-5195 8 21 presentation presentation NOUN fnp-5195 8 22 by by ADP fnp-5195 8 23 a a DET fnp-5195 8 24 trainee trainee NOUN fnp-5195 8 25 was be AUX fnp-5195 8 26 won win VERB fnp-5195 8 27 by by ADP fnp-5195 8 28 dr dr PROPN fnp-5195 8 29 . . PROPN fnp-5195 8 30 r. r. PROPN fnp-5195 8 31 cotau cotau PROPN fnp-5195 8 32 ( ( PUNCT fnp-5195 8 33 supervisor supervisor NOUN fnp-5195 8 34 dr dr PROPN fnp-5195 8 35 . . PROPN fnp-5195 8 36 m. m. PROPN fnp-5195 8 37 richer richer PROPN fnp-5195 8 38 ) ) PUNCT fnp-5195 8 39 . . PUNCT fnp-5195 9 1 the the DET fnp-5195 9 2 following follow VERB fnp-5195 9 3 abstracts abstract NOUN fnp-5195 9 4 were be AUX fnp-5195 9 5 presented present VERB fnp-5195 9 6 at at ADP fnp-5195 9 7 the the DET fnp-5195 9 8 63rd 63rd ADJ fnp-5195 9 9 annual annual ADJ fnp-5195 9 10 meeting meeting NOUN fnp-5195 9 11 of of ADP fnp-5195 9 12 the the DET fnp-5195 9 13 canadian canadian PROPN fnp-5195 9 14 association association NOUN fnp-5195 9 15 of of ADP fnp-5195 9 16 neuropathologists neuropathologist NOUN fnp-5195 9 17 – – PUNCT fnp-5195 9 18 association association PROPN fnp-5195 9 19 candienne candienne PROPN fnp-5195 9 20 des des PROPN fnp-5195 9 21 neuropathologistes neuropathologistes PROPN fnp-5195 9 22 ( ( PUNCT fnp-5195 9 23 canp canp NOUN fnp-5195 9 24 - - PUNCT fnp-5195 9 25 acnp acnp NOUN fnp-5195 9 26 ) ) PUNCT fnp-5195 9 27 in in ADP fnp-5195 9 28 october october PROPN fnp-5195 9 29 2023 2023 NUM fnp-5195 9 30 . . PUNCT fnp-5195 9 31     SPACE fnp-5195 10 1 https://doi.org/10.17879/freeneuropathology-2023-5195 https://doi.org/10.17879/freeneuropathology-2023-5195 NOUN fnp-5195 10 2 keywords keyword NOUN fnp-5195 10 3 : : PUNCT fnp-5195 10 4 canadian canadian ADJ fnp-5195 10 5 association association NOUN fnp-5195 10 6 of of ADP fnp-5195 10 7 neuropathologists neuropathologist NOUN fnp-5195 10 8 , , PUNCT fnp-5195 10 9 canp canp NOUN fnp-5195 10 10 , , PUNCT fnp-5195 10 11 meeting meet VERB fnp-5195 10 12 abstracts abstract NOUN fnp-5195 10 13 , , PUNCT fnp-5195 10 14 63rd 63rd ADJ fnp-5195 10 15 meeting meeting NOUN fnp-5195 10 16 oct oct PROPN fnp-5195 10 17 . . PROPN fnp-5195 10 18 2023 2023 NUM fnp-5195 10 19 contents content NOUN fnp-5195 10 20 abstract abstract NOUN fnp-5195 10 21     SPACE fnp-5195 10 22 1 1 NUM fnp-5195 10 23 : : PUNCT fnp-5195 10 24 aqueductal aqueductal VERB fnp-5195 10 25 stenosis stenosis NOUN fnp-5195 10 26 and and CCONJ fnp-5195 10 27 mesencephalosynapsis mesencephalosynapsis NOUN fnp-5195 10 28 in in ADP fnp-5195 10 29 fetal fetal ADJ fnp-5195 10 30 brains brain NOUN fnp-5195 10 31 , , PUNCT fnp-5195 10 32 part part NOUN fnp-5195 10 33 1 1 NUM fnp-5195 10 34 : : PUNCT fnp-5195 10 35 classification classification NOUN fnp-5195 10 36 , , PUNCT fnp-5195 10 37 and and CCONJ fnp-5195 10 38 morphology morphology NOUN fnp-5195 10 39 abstract abstract NOUN fnp-5195 10 40     SPACE fnp-5195 10 41 2 2 NUM fnp-5195 10 42 : : PUNCT fnp-5195 10 43 aqueductal aqueductal VERB fnp-5195 10 44 stenosis stenosis NOUN fnp-5195 10 45 and and CCONJ fnp-5195 10 46 mesencephalosynapsis mesencephalosynapsis NOUN fnp-5195 10 47 in in ADP fnp-5195 10 48 fetal fetal ADJ fnp-5195 10 49 brains brain NOUN fnp-5195 10 50 , , PUNCT fnp-5195 10 51 part part NOUN fnp-5195 10 52 2 2 NUM fnp-5195 10 53 : : PUNCT fnp-5195 10 54 associations association NOUN fnp-5195 10 55 abstract abstract NOUN fnp-5195 10 56     SPACE fnp-5195 10 57 3 3 NUM fnp-5195 10 58 : : PUNCT fnp-5195 10 59 a a DET fnp-5195 10 60 novel novel ADJ fnp-5195 10 61 association association NOUN fnp-5195 10 62 : : PUNCT fnp-5195 10 63 distal distal ADJ fnp-5195 10 64 arthrogryposis arthrogryposis NOUN fnp-5195 10 65 , , PUNCT fnp-5195 10 66 kif21a kif21a PROPN fnp-5195 10 67 and and CCONJ fnp-5195 10 68 fetal fetal ADJ fnp-5195 10 69 neuroaxonal neuroaxonal ADJ fnp-5195 10 70 dystrophy dystrophy NOUN fnp-5195 10 71 abstract abstract NOUN fnp-5195 10 72     SPACE fnp-5195 10 73 4 4 NUM fnp-5195 10 74 : : PUNCT fnp-5195 10 75 polymicrogyria polymicrogyria NOUN fnp-5195 10 76 through through ADP fnp-5195 10 77 a a DET fnp-5195 10 78 tensegrity tensegrity NOUN fnp-5195 10 79 lens lens NOUN fnp-5195 10 80 abstract abstract NOUN fnp-5195 10 81     SPACE fnp-5195 10 82 5 5 NUM fnp-5195 10 83 : : PUNCT fnp-5195 10 84 imaging image VERB fnp-5195 10 85 axonal axonal ADJ fnp-5195 10 86 pathology pathology NOUN fnp-5195 10 87 in in ADP fnp-5195 10 88 the the DET fnp-5195 10 89 retina retina NOUN fnp-5195 10 90 as as ADP fnp-5195 10 91 a a DET fnp-5195 10 92 potential potential ADJ fnp-5195 10 93 non non ADJ fnp-5195 10 94 - - ADJ fnp-5195 10 95 invasive invasive ADJ fnp-5195 10 96 biomarker biomarker NOUN fnp-5195 10 97 for for ADP fnp-5195 10 98 amyotrophic amyotrophic ADJ fnp-5195 10 99 lateral lateral ADJ fnp-5195 10 100 sclerosis sclerosis NOUN fnp-5195 10 101 abstract abstract NOUN fnp-5195 10 102     SPACE fnp-5195 10 103 6 6 NUM fnp-5195 10 104 : : PUNCT fnp-5195 10 105 progressive progressive ADJ fnp-5195 10 106 supranuclear supranuclear ADJ fnp-5195 10 107 palsy palsy ADJ fnp-5195 10 108 : : PUNCT fnp-5195 10 109 a a DET fnp-5195 10 110 novel novel ADJ fnp-5195 10 111 phenotype phenotype NOUN fnp-5195 10 112 of of ADP fnp-5195 10 113 germline germline PROPN fnp-5195 10 114 sqstm1 sqstm1 PROPN fnp-5195 10 115 ( ( PUNCT fnp-5195 10 116 p62 p62 NOUN fnp-5195 10 117 ) ) PUNCT fnp-5195 10 118 mutation mutation NOUN fnp-5195 10 119 abstract abstract NOUN fnp-5195 10 120     SPACE fnp-5195 10 121 7 7 NUM fnp-5195 10 122 : : PUNCT fnp-5195 10 123 a a DET fnp-5195 10 124 108 108 NUM fnp-5195 10 125 year year NOUN fnp-5195 10 126 old old ADJ fnp-5195 10 127 brain brain NOUN fnp-5195 10 128 with with ADP fnp-5195 10 129 near near ADJ fnp-5195 10 130 normal normal ADJ fnp-5195 10 131 cognition cognition NOUN fnp-5195 10 132 abstract abstract NOUN fnp-5195 10 133     SPACE fnp-5195 10 134 8 8 NUM fnp-5195 10 135 : : PUNCT fnp-5195 10 136 cellular cellular ADJ fnp-5195 10 137 activation activation NOUN fnp-5195 10 138 patterns pattern NOUN fnp-5195 10 139 of of ADP fnp-5195 10 140 cd10 cd10 PROPN fnp-5195 10 141 + + CCONJ fnp-5195 10 142 fibro fibro PROPN fnp-5195 10 143 - - PUNCT fnp-5195 10 144 adipogenic adipogenic ADJ fnp-5195 10 145 progenitors progenitor NOUN fnp-5195 10 146 across across ADP fnp-5195 10 147 acquired acquire VERB fnp-5195 10 148 disease disease NOUN fnp-5195 10 149 states state NOUN fnp-5195 10 150 in in ADP fnp-5195 10 151 human human ADJ fnp-5195 10 152 skeletal skeletal ADJ fnp-5195 10 153 muscle muscle NOUN fnp-5195 10 154 biopsies biopsy NOUN fnp-5195 10 155 abstract abstract ADJ fnp-5195 10 156     SPACE fnp-5195 10 157 9 9 NUM fnp-5195 10 158 : : PUNCT fnp-5195 10 159 assessment assessment NOUN fnp-5195 10 160 challenges challenge NOUN fnp-5195 10 161 and and CCONJ fnp-5195 10 162 headaches headache NOUN fnp-5195 10 163 in in ADP fnp-5195 10 164 the the DET fnp-5195 10 165 implementation implementation NOUN fnp-5195 10 166 of of ADP fnp-5195 10 167 competence competence NOUN fnp-5195 10 168 by by ADP fnp-5195 10 169 design design NOUN fnp-5195 10 170 ( ( PUNCT fnp-5195 10 171 cbd cbd NOUN fnp-5195 10 172 ): ): PUNCT fnp-5195 10 173 the the DET fnp-5195 10 174 experience experience NOUN fnp-5195 10 175 in in ADP fnp-5195 10 176 a a DET fnp-5195 10 177 diagnostic diagnostic ADJ fnp-5195 10 178 and and CCONJ fnp-5195 10 179 molecular molecular ADJ fnp-5195 10 180 pathology pathology NOUN fnp-5195 10 181 residency residency NOUN fnp-5195 10 182 program program NOUN fnp-5195 10 183 abstract abstract NOUN fnp-5195 10 184     SPACE fnp-5195 10 185 10 10 NUM fnp-5195 10 186 : : PUNCT fnp-5195 10 187 isolated isolate VERB fnp-5195 10 188 small small ADJ fnp-5195 10 189 vessel vessel NOUN fnp-5195 10 190 inflammation inflammation NOUN fnp-5195 10 191 in in ADP fnp-5195 10 192 temporal temporal ADJ fnp-5195 10 193 artery artery NOUN fnp-5195 10 194 biopsies biopsy NOUN fnp-5195 10 195 : : PUNCT fnp-5195 10 196 small small ADJ fnp-5195 10 197 red red ADJ fnp-5195 10 198 flags flag NOUN fnp-5195 10 199 abstract abstract ADJ fnp-5195 10 200     SPACE fnp-5195 10 201 11 11 NUM fnp-5195 10 202 : : PUNCT fnp-5195 10 203 the the DET fnp-5195 10 204 international international ADJ fnp-5195 10 205 spinal spinal PROPN fnp-5195 10 206 cord cord NOUN fnp-5195 10 207 injury injury NOUN fnp-5195 10 208 biobank biobank PROPN fnp-5195 10 209 : : PUNCT fnp-5195 10 210 neuropathological neuropathological ADJ fnp-5195 10 211 contributions contribution NOUN fnp-5195 10 212 to to ADP fnp-5195 10 213 global global ADJ fnp-5195 10 214 translational translational ADJ fnp-5195 10 215 research research NOUN fnp-5195 10 216 in in ADP fnp-5195 10 217 traumatic traumatic ADJ fnp-5195 10 218 spinal spinal PROPN fnp-5195 10 219 cord cord NOUN fnp-5195 10 220 injury injury NOUN fnp-5195 10 221 abstract abstract NOUN fnp-5195 10 222     SPACE fnp-5195 10 223 12 12 NUM fnp-5195 10 224 : : PUNCT fnp-5195 10 225 death death NOUN fnp-5195 10 226 and and CCONJ fnp-5195 10 227 the the DET fnp-5195 10 228 maid maid NOUN fnp-5195 10 229 at at ADP fnp-5195 10 230 the the DET fnp-5195 10 231 calgary calgary PROPN fnp-5195 10 232 brain brain PROPN fnp-5195 10 233 bank bank PROPN fnp-5195 10 234 abstract abstract NOUN fnp-5195 10 235     SPACE fnp-5195 10 236 13 13 NUM fnp-5195 10 237 : : PUNCT fnp-5195 10 238 pathology pathology NOUN fnp-5195 10 239 of of ADP fnp-5195 10 240 the the DET fnp-5195 10 241 vertebral vertebral ADJ fnp-5195 10 242 artery artery NOUN fnp-5195 10 243 in in ADP fnp-5195 10 244 medicolegal medicolegal ADJ fnp-5195 10 245 autopsies autopsy NOUN fnp-5195 10 246 abstract abstract ADJ fnp-5195 10 247     SPACE fnp-5195 10 248 14 14 NUM fnp-5195 10 249 : : PUNCT fnp-5195 10 250 study study NOUN fnp-5195 10 251 of of ADP fnp-5195 10 252 gamma gamma NOUN fnp-5195 10 253 - - PUNCT fnp-5195 10 254 aminobutyric aminobutyric ADJ fnp-5195 10 255 acid acid NOUN fnp-5195 10 256 and and CCONJ fnp-5195 10 257 glutamate glutamate VERB fnp-5195 10 258 signaling signal VERB fnp-5195 10 259 pathways pathway NOUN fnp-5195 10 260 in in ADP fnp-5195 10 261 glioblastoma glioblastoma NOUN fnp-5195 10 262 abstract abstract NOUN fnp-5195 10 263     SPACE fnp-5195 10 264 15 15 NUM fnp-5195 10 265 : : PUNCT fnp-5195 10 266 using use VERB fnp-5195 10 267 molecular molecular ADJ fnp-5195 10 268 and and CCONJ fnp-5195 10 269 immunohistochemical immunohistochemical ADJ fnp-5195 10 270 features feature NOUN fnp-5195 10 271 to to PART fnp-5195 10 272 predict predict VERB fnp-5195 10 273 outcomes outcome NOUN fnp-5195 10 274 in in ADP fnp-5195 10 275 grade grade NOUN fnp-5195 10 276 3 3 NUM fnp-5195 10 277 meningiomas meningioma NOUN fnp-5195 10 278 abstract abstract NOUN fnp-5195 10 279     SPACE fnp-5195 10 280 16 16 NUM fnp-5195 10 281 : : PUNCT fnp-5195 10 282 pediatric pediatric ADJ fnp-5195 10 283 - - PUNCT fnp-5195 10 284 type type NOUN fnp-5195 10 285 gliomas glioma NOUN fnp-5195 10 286 in in ADP fnp-5195 10 287 adults adult NOUN fnp-5195 10 288 : : PUNCT fnp-5195 10 289 pathologic pathologic ADJ fnp-5195 10 290 and and CCONJ fnp-5195 10 291 molecular molecular ADJ fnp-5195 10 292 features feature NOUN fnp-5195 10 293 abstract abstract ADJ fnp-5195 10 294     SPACE fnp-5195 10 295 17 17 NUM fnp-5195 10 296 : : PUNCT fnp-5195 10 297 extra extra ADJ fnp-5195 10 298 - - ADJ fnp-5195 10 299 pineal pineal ADJ fnp-5195 10 300 papillary papillary ADJ fnp-5195 10 301 tumor tumor NOUN fnp-5195 10 302 of of ADP fnp-5195 10 303 the the DET fnp-5195 10 304 pineal pineal NOUN fnp-5195 10 305 region region NOUN fnp-5195 10 306 ( ( PUNCT fnp-5195 10 307 ptpr ptpr PROPN fnp-5195 10 308 ) ) PUNCT fnp-5195 10 309 masquarading masquarading NOUN fnp-5195 10 310 as as ADP fnp-5195 10 311 a a DET fnp-5195 10 312 subependymal subependymal ADJ fnp-5195 10 313 giant giant ADJ fnp-5195 10 314 cell cell NOUN fnp-5195 10 315 tumor tumor NOUN fnp-5195 10 316 ( ( PUNCT fnp-5195 10 317 sega sega NOUN fnp-5195 10 318 ) ) PUNCT fnp-5195 10 319 abstract abstract ADJ fnp-5195 10 320     SPACE fnp-5195 10 321 18 18 NUM fnp-5195 10 322 : : PUNCT fnp-5195 10 323 ethical ethical ADJ fnp-5195 10 324 considerations consideration NOUN fnp-5195 10 325 in in ADP fnp-5195 10 326 the the DET fnp-5195 10 327 use use NOUN fnp-5195 10 328 of of ADP fnp-5195 10 329 dna dna PROPN fnp-5195 10 330 methylation methylation NOUN fnp-5195 10 331 profiling profiling NOUN fnp-5195 10 332 for for ADP fnp-5195 10 333 tumor tumor NOUN fnp-5195 10 334 diagnostics diagnostic NOUN fnp-5195 10 335         SPACE fnp-5195 10 336 abstract abstract ADJ fnp-5195 10 337 1 1 NUM fnp-5195 10 338 free free ADJ fnp-5195 10 339 neuropathol neuropathol NOUN fnp-5195 10 340 4:20:4 4:20:4 NUM fnp-5195 10 341 aqueductal aqueductal ADJ fnp-5195 10 342 stenosis stenosis NOUN fnp-5195 10 343 and and CCONJ fnp-5195 10 344 mesencephalosynapsis mesencephalosynapsis NOUN fnp-5195 10 345 in in ADP fnp-5195 10 346 fetal fetal ADJ fnp-5195 10 347 brains brain NOUN fnp-5195 10 348 , , PUNCT fnp-5195 10 349 part part NOUN fnp-5195 10 350 1 1 NUM fnp-5195 10 351 : : PUNCT fnp-5195 10 352 classification classification NOUN fnp-5195 10 353 , , PUNCT fnp-5195 10 354 and and CCONJ fnp-5195 10 355 morphology morphology NOUN fnp-5195 10 356 yael yael PROPN fnp-5195 10 357 fisher1 fisher1 PROPN fnp-5195 10 358 , , PUNCT fnp-5195 10 359 orli orli PROPN fnp-5195 10 360 greenberg1 greenberg1 PROPN fnp-5195 10 361 , , PUNCT fnp-5195 10 362 patrick patrick PROPN fnp-5195 10 363 shannon1 shannon1 PROPN fnp-5195 10 364 1 1 NUM fnp-5195 10 365 pathology pathology NOUN fnp-5195 10 366 and and CCONJ fnp-5195 10 367 laboratory laboratory NOUN fnp-5195 10 368 medicine medicine NOUN fnp-5195 10 369 , , PUNCT fnp-5195 10 370 mount mount PROPN fnp-5195 10 371 sinai sinai PROPN fnp-5195 10 372 , , PUNCT fnp-5195 10 373 toronto toronto PROPN fnp-5195 10 374 , , PUNCT fnp-5195 10 375 on on ADP fnp-5195 10 376 , , PUNCT fnp-5195 10 377 canada canada PROPN fnp-5195 10 378 systematic systematic PROPN fnp-5195 10 379 studies study NOUN fnp-5195 10 380 of of ADP fnp-5195 10 381 the the DET fnp-5195 10 382 histology histology NOUN fnp-5195 10 383 of of ADP fnp-5195 10 384 fetal fetal ADJ fnp-5195 10 385 aqueductal aqueductal ADJ fnp-5195 10 386 stenosis stenosis NOUN fnp-5195 10 387 ( ( PUNCT fnp-5195 10 388 as as ADP fnp-5195 10 389 ) ) PUNCT fnp-5195 10 390 are be AUX fnp-5195 10 391 uncommon uncommon ADJ fnp-5195 10 392 . . PUNCT fnp-5195 11 1 mesencecphalosynapsis mesencecphalosynapsis NOUN fnp-5195 11 2 , , PUNCT fnp-5195 11 3 ( ( PUNCT fnp-5195 11 4 midline midline NOUN fnp-5195 11 5 fusion fusion NOUN fnp-5195 11 6 of of ADP fnp-5195 11 7 the the DET fnp-5195 11 8 midbrain midbrain NOUN fnp-5195 11 9 colliculi colliculi NOUN fnp-5195 11 10 with with ADP fnp-5195 11 11 absence absence NOUN fnp-5195 11 12 of of ADP fnp-5195 11 13 the the DET fnp-5195 11 14 dorsal dorsal NOUN fnp-5195 11 15 medial medial ADJ fnp-5195 11 16 septum septum PROPN fnp-5195 11 17 ) ) PUNCT fnp-5195 11 18 , , PUNCT fnp-5195 11 19 is be AUX fnp-5195 11 20 infrequently infrequently ADV fnp-5195 11 21 described describe VERB fnp-5195 11 22 in in ADP fnp-5195 11 23 the the DET fnp-5195 11 24 literature literature NOUN fnp-5195 11 25 in in ADP fnp-5195 11 26 association association NOUN fnp-5195 11 27 with with ADP fnp-5195 11 28 brain brain NOUN fnp-5195 11 29 malformations malformation NOUN fnp-5195 11 30 . . PUNCT fnp-5195 12 1 we we PRON fnp-5195 12 2 conducted conduct VERB fnp-5195 12 3 a a DET fnp-5195 12 4 12 12 NUM fnp-5195 12 5 year year NOUN fnp-5195 12 6 review review NOUN fnp-5195 12 7 of of ADP fnp-5195 12 8 our our PRON fnp-5195 12 9 institutional institutional ADJ fnp-5195 12 10 experience experience NOUN fnp-5195 12 11 with with ADP fnp-5195 12 12 fetal fetal ADJ fnp-5195 12 13 obstructive obstructive ADJ fnp-5195 12 14 hydrocephalus hydrocephalus NOUN fnp-5195 12 15 and and CCONJ fnp-5195 12 16 as as ADP fnp-5195 12 17 using use VERB fnp-5195 12 18 text text NOUN fnp-5195 12 19 word word NOUN fnp-5195 12 20 searches search NOUN fnp-5195 12 21 for for ADP fnp-5195 12 22 aqueductal aqueductal ADJ fnp-5195 12 23 stenosis stenosis NOUN fnp-5195 12 24 , , PUNCT fnp-5195 12 25 aqueductal aqueductal ADJ fnp-5195 12 26 atresia atresia NOUN fnp-5195 12 27 , , PUNCT fnp-5195 12 28 ventriculomegaly ventriculomegaly ADJ fnp-5195 12 29 , , PUNCT fnp-5195 12 30 hydrocephalus hydrocephalus ADJ fnp-5195 12 31 and and CCONJ fnp-5195 12 32 rhombencephalosynapsis rhombencephalosynapsis NOUN fnp-5195 12 33 . . PUNCT fnp-5195 13 1 we we PRON fnp-5195 13 2 obtained obtain VERB fnp-5195 13 3 274 274 NUM fnp-5195 13 4 cases case NOUN fnp-5195 13 5 . . PUNCT fnp-5195 14 1 we we PRON fnp-5195 14 2 excluded exclude VERB fnp-5195 14 3 chiari chiari NOUN fnp-5195 14 4 malformations malformation NOUN fnp-5195 14 5 , , PUNCT fnp-5195 14 6 skeletal skeletal ADJ fnp-5195 14 7 dysplasias dysplasia NOUN fnp-5195 14 8 , , PUNCT fnp-5195 14 9 ex ex NOUN fnp-5195 14 10 - - ADJ fnp-5195 14 11 vacuo vacuo ADJ fnp-5195 14 12 ventriculomegaly ventriculomegaly NOUN fnp-5195 14 13 and and CCONJ fnp-5195 14 14 cases case NOUN fnp-5195 14 15 with with ADP fnp-5195 14 16 unsatisfactory unsatisfactory ADJ fnp-5195 14 17 representation representation NOUN fnp-5195 14 18 of of ADP fnp-5195 14 19 the the DET fnp-5195 14 20 midbrain midbrain NOUN fnp-5195 14 21 . . PUNCT fnp-5195 15 1 118 118 NUM fnp-5195 15 2 cases case NOUN fnp-5195 15 3 of of ADP fnp-5195 15 4 obstructive obstructive ADJ fnp-5195 15 5 ventriculomegaly ventriculomegaly NOUN fnp-5195 15 6 with with ADP fnp-5195 15 7 aqueductal aqueductal ADJ fnp-5195 15 8 pathology pathology NOUN fnp-5195 15 9 remained remain VERB fnp-5195 15 10 . . PUNCT fnp-5195 16 1 clinical clinical ADJ fnp-5195 16 2 and and CCONJ fnp-5195 16 3 histological histological ADJ fnp-5195 16 4 features feature NOUN fnp-5195 16 5 of of ADP fnp-5195 16 6 each each DET fnp-5195 16 7 case case NOUN fnp-5195 16 8 were be AUX fnp-5195 16 9 reviewed review VERB fnp-5195 16 10 . . PUNCT fnp-5195 17 1 the the DET fnp-5195 17 2 median median ADJ fnp-5195 17 3 gestational gestational ADJ fnp-5195 17 4 age age NOUN fnp-5195 17 5 was be AUX fnp-5195 17 6 23 23 NUM fnp-5195 17 7 weeks week NOUN fnp-5195 17 8 , , PUNCT fnp-5195 17 9 interquartile interquartile ADJ fnp-5195 17 10 range range NOUN fnp-5195 17 11 = = SYM fnp-5195 17 12 21 21 NUM fnp-5195 17 13 to to PART fnp-5195 17 14 25 25 NUM fnp-5195 17 15 weeks week NOUN fnp-5195 17 16 . . PUNCT fnp-5195 18 1 we we PRON fnp-5195 18 2 identified identify VERB fnp-5195 18 3 5 5 NUM fnp-5195 18 4 major major ADJ fnp-5195 18 5 morphological morphological ADJ fnp-5195 18 6 patterns pattern NOUN fnp-5195 18 7 of of ADP fnp-5195 18 8 as as ADP fnp-5195 18 9 . . PROPN fnp-5195 18 10 1 1 NUM fnp-5195 18 11 ) ) PUNCT fnp-5195 18 12 aqueductal aqueductal ADJ fnp-5195 18 13 atresia atresia NOUN fnp-5195 18 14 ( ( PUNCT fnp-5195 18 15 14 14 NUM fnp-5195 18 16 of of ADP fnp-5195 18 17 118 118 NUM fnp-5195 18 18 , , PUNCT fnp-5195 18 19 11.9 11.9 NUM fnp-5195 18 20 % % NOUN fnp-5195 18 21 ) ) PUNCT fnp-5195 18 22 ; ; PUNCT fnp-5195 18 23 2 2 X fnp-5195 18 24 ) ) PUNCT fnp-5195 18 25 severe severe ADJ fnp-5195 18 26 stenosis stenosis NOUN fnp-5195 18 27 ( ( PUNCT fnp-5195 18 28 22 22 NUM fnp-5195 18 29 of of ADP fnp-5195 18 30 118 118 NUM fnp-5195 18 31 , , PUNCT fnp-5195 18 32 18.6 18.6 NUM fnp-5195 18 33 % % NOUN fnp-5195 18 34 ) ) PUNCT fnp-5195 18 35 ; ; PUNCT fnp-5195 18 36 3 3 X fnp-5195 18 37 ) ) PUNCT fnp-5195 18 38 mild mild ADJ fnp-5195 18 39 stenosis stenosis NOUN fnp-5195 18 40 ( ( PUNCT fnp-5195 18 41 51 51 NUM fnp-5195 18 42 of of ADP fnp-5195 18 43 118 118 NUM fnp-5195 18 44 , , PUNCT fnp-5195 18 45 43.2 43.2 NUM fnp-5195 18 46 % % NOUN fnp-5195 18 47 ) ) PUNCT fnp-5195 18 48 ; ; PUNCT fnp-5195 18 49 4 4 X fnp-5195 18 50 ) ) PUNCT fnp-5195 18 51 borderline borderline NOUN fnp-5195 18 52 stenosis stenosis NOUN fnp-5195 18 53 ( ( PUNCT fnp-5195 18 54 10 10 NUM fnp-5195 18 55 of of ADP fnp-5195 18 56 118 118 NUM fnp-5195 18 57 , , PUNCT fnp-5195 18 58 8.5 8.5 NUM fnp-5195 18 59 % % NOUN fnp-5195 18 60 ) ) PUNCT fnp-5195 18 61 ; ; PUNCT fnp-5195 18 62 5 5 X fnp-5195 18 63 ) ) PUNCT fnp-5195 18 64 slit slit NOUN fnp-5195 18 65 - - PUNCT fnp-5195 18 66 like like ADJ fnp-5195 18 67 aqueduct aqueduct NOUN fnp-5195 18 68 ( ( PUNCT fnp-5195 18 69 13 13 NUM fnp-5195 18 70 of of ADP fnp-5195 18 71 118 118 NUM fnp-5195 18 72 , , PUNCT fnp-5195 18 73 11 11 NUM fnp-5195 18 74 % % NOUN fnp-5195 18 75 ) ) PUNCT fnp-5195 18 76 . . PUNCT fnp-5195 19 1 8 8 NUM fnp-5195 19 2 cases case NOUN fnp-5195 19 3 had have VERB fnp-5195 19 4 a a DET fnp-5195 19 5 seemingly seemingly ADV fnp-5195 19 6 patent patent NOUN fnp-5195 19 7 aqueduct aqueduct NOUN fnp-5195 19 8 ( ( PUNCT fnp-5195 19 9 6.8 6.8 NUM fnp-5195 19 10 % % NOUN fnp-5195 19 11 ) ) PUNCT fnp-5195 19 12 , , PUNCT fnp-5195 19 13 but but CCONJ fnp-5195 19 14 7 7 NUM fnp-5195 19 15 of of ADP fnp-5195 19 16 these these PRON fnp-5195 19 17 had have VERB fnp-5195 19 18 a a DET fnp-5195 19 19 clear clear ADJ fnp-5195 19 20 obstructive obstructive ADJ fnp-5195 19 21 lesion lesion NOUN fnp-5195 19 22 ( ( PUNCT fnp-5195 19 23 2 2 NUM fnp-5195 19 24 had have AUX fnp-5195 19 25 isolated isolate VERB fnp-5195 19 26 glial glial ADJ fnp-5195 19 27 webbing webbing NOUN fnp-5195 19 28 of of ADP fnp-5195 19 29 the the DET fnp-5195 19 30 aqueduct aqueduct NOUN fnp-5195 19 31 , , PUNCT fnp-5195 19 32 5 5 NUM fnp-5195 19 33 had have VERB fnp-5195 19 34 other other ADJ fnp-5195 19 35 outflow outflow ADJ fnp-5195 19 36 obstructions obstruction NOUN fnp-5195 19 37 ) ) PUNCT fnp-5195 19 38 . . PUNCT fnp-5195 20 1 mesencephalosynapsis mesencephalosynapsis NOUN fnp-5195 20 2 was be AUX fnp-5195 20 3 seen see VERB fnp-5195 20 4 in in ADP fnp-5195 20 5 42 42 NUM fnp-5195 20 6 of of ADP fnp-5195 20 7 118 118 NUM fnp-5195 20 8 cases case NOUN fnp-5195 20 9 ( ( PUNCT fnp-5195 20 10 35.6 35.6 NUM fnp-5195 20 11 % % NOUN fnp-5195 20 12 ) ) PUNCT fnp-5195 20 13 , , PUNCT fnp-5195 20 14 more more ADV fnp-5195 20 15 commonly commonly ADV fnp-5195 20 16 in in ADP fnp-5195 20 17 cases case NOUN fnp-5195 20 18 of of ADP fnp-5195 20 19 atresia atresia NOUN fnp-5195 20 20 and and CCONJ fnp-5195 20 21 severe severe ADJ fnp-5195 20 22 stenosis stenosis NOUN fnp-5195 20 23 . . PUNCT fnp-5195 21 1 hemosiderin hemosiderin PROPN fnp-5195 21 2 laden laden PROPN fnp-5195 21 3 macrophages macrophage NOUN fnp-5195 21 4 were be AUX fnp-5195 21 5 present present ADJ fnp-5195 21 6 in in ADP fnp-5195 21 7 the the DET fnp-5195 21 8 aqueduct aqueduct NOUN fnp-5195 21 9 39 39 NUM fnp-5195 21 10 of of ADP fnp-5195 21 11 118 118 NUM fnp-5195 21 12 cases case NOUN fnp-5195 21 13 ( ( PUNCT fnp-5195 21 14 33.1 33.1 NUM fnp-5195 21 15 % % NOUN fnp-5195 21 16 ) ) PUNCT fnp-5195 21 17 . . PUNCT fnp-5195 22 1 atresia atresia NOUN fnp-5195 22 2 and and CCONJ fnp-5195 22 3 severe severe ADJ fnp-5195 22 4 as as SCONJ fnp-5195 22 5 showed show VERB fnp-5195 22 6 a a DET fnp-5195 22 7 stronger strong ADJ fnp-5195 22 8 association association NOUN fnp-5195 22 9 with with ADP fnp-5195 22 10 multiple multiple ADJ fnp-5195 22 11 congenital congenital ADJ fnp-5195 22 12 anomalies anomaly NOUN fnp-5195 22 13 and and CCONJ fnp-5195 22 14 other other ADJ fnp-5195 22 15 central central ADJ fnp-5195 22 16 nervous nervous ADJ fnp-5195 22 17 system system NOUN fnp-5195 22 18 malformations malformation NOUN fnp-5195 22 19 when when SCONJ fnp-5195 22 20 compared compare VERB fnp-5195 22 21 with with ADP fnp-5195 22 22 the the DET fnp-5195 22 23 milder mild ADJ fnp-5195 22 24 forms form NOUN fnp-5195 22 25 of of ADP fnp-5195 22 26 as as ADP fnp-5195 22 27 . . PUNCT fnp-5195 22 28     SPACE fnp-5195 22 29 abstract abstract ADJ fnp-5195 22 30 2 2 NUM fnp-5195 22 31 free free ADJ fnp-5195 22 32 neuropathol neuropathol NOUN fnp-5195 22 33 4:20:5 4:20:5 NUM fnp-5195 22 34 aqueductal aqueductal ADJ fnp-5195 22 35 stenosis stenosis NOUN fnp-5195 22 36 and and CCONJ fnp-5195 22 37 mesencephalosynapsis mesencephalosynapsis NOUN fnp-5195 22 38 in in ADP fnp-5195 22 39 fetal fetal ADJ fnp-5195 22 40 brains brain NOUN fnp-5195 22 41 , , PUNCT fnp-5195 22 42 part part NOUN fnp-5195 22 43 2 2 NUM fnp-5195 22 44 : : PUNCT fnp-5195 22 45 associations association NOUN fnp-5195 22 46 yael yael PROPN fnp-5195 22 47 fisher1 fisher1 PROPN fnp-5195 22 48 , , PUNCT fnp-5195 22 49 orli orli PROPN fnp-5195 22 50 greenberg1 greenberg1 PROPN fnp-5195 22 51 , , PUNCT fnp-5195 22 52 patrick patrick PROPN fnp-5195 22 53 shannon1 shannon1 PROPN fnp-5195 22 54 1 1 NUM fnp-5195 22 55 pathology pathology NOUN fnp-5195 22 56 and and CCONJ fnp-5195 22 57 laboratory laboratory NOUN fnp-5195 22 58 medicine medicine NOUN fnp-5195 22 59 , , PUNCT fnp-5195 22 60 mount mount PROPN fnp-5195 22 61 sinai sinai PROPN fnp-5195 22 62 , , PUNCT fnp-5195 22 63 toronto toronto PROPN fnp-5195 22 64 , , PUNCT fnp-5195 22 65 on on ADP fnp-5195 22 66 , , PUNCT fnp-5195 22 67 canada canada PROPN fnp-5195 22 68 as as ADP fnp-5195 22 69 part part NOUN fnp-5195 22 70 of of ADP fnp-5195 22 71 our our PRON fnp-5195 22 72 review review NOUN fnp-5195 22 73 of of ADP fnp-5195 22 74 fetal fetal ADJ fnp-5195 22 75 aqueductal aqueductal ADJ fnp-5195 22 76 histopathology histopathology NOUN fnp-5195 22 77 , , PUNCT fnp-5195 22 78 we we PRON fnp-5195 22 79 reviewed review VERB fnp-5195 22 80 the the DET fnp-5195 22 81 brain brain NOUN fnp-5195 22 82 and and CCONJ fnp-5195 22 83 autopsy autopsy ADJ fnp-5195 22 84 findings finding NOUN fnp-5195 22 85 accompanying accompany VERB fnp-5195 22 86 the the DET fnp-5195 22 87 morphologies morphology NOUN fnp-5195 22 88 of of ADP fnp-5195 22 89 aqueductal aqueductal ADJ fnp-5195 22 90 stenosis stenosis NOUN fnp-5195 22 91 ( ( PUNCT fnp-5195 22 92 as as ADP fnp-5195 22 93 ) ) PUNCT fnp-5195 22 94 and and CCONJ fnp-5195 22 95 mesencephalosynapsis mesencephalosynapsis NOUN fnp-5195 22 96 ( ( PUNCT fnp-5195 22 97 mes mes PROPN fnp-5195 22 98 ) ) PUNCT fnp-5195 22 99 , , PUNCT fnp-5195 22 100 the the DET fnp-5195 22 101 absence absence NOUN fnp-5195 22 102 of of ADP fnp-5195 22 103 the the DET fnp-5195 22 104 median median ADJ fnp-5195 22 105 dorsal dorsal NOUN fnp-5195 22 106 glial glial ADJ fnp-5195 22 107 septum septum NOUN fnp-5195 22 108 , , PUNCT fnp-5195 22 109 in in ADP fnp-5195 22 110 118 118 NUM fnp-5195 22 111 cases case NOUN fnp-5195 22 112 of of ADP fnp-5195 22 113 fetal fetal ADJ fnp-5195 22 114 hydrocephalus hydrocephalus NOUN fnp-5195 22 115 . . PUNCT fnp-5195 23 1 we we PRON fnp-5195 23 2 encountered encounter VERB fnp-5195 23 3 some some DET fnp-5195 23 4 novel novel ADJ fnp-5195 23 5 associations association NOUN fnp-5195 23 6 . . PUNCT fnp-5195 24 1 1 1 X fnp-5195 24 2 . . X fnp-5195 24 3 rhombencephalosynapsis rhombencephalosynapsis NOUN fnp-5195 24 4 : : PUNCT fnp-5195 24 5 21 21 NUM fnp-5195 24 6 of of ADP fnp-5195 24 7 24 24 NUM fnp-5195 24 8 ( ( PUNCT fnp-5195 24 9 87.5 87.5 NUM fnp-5195 24 10 % % NOUN fnp-5195 24 11 ) ) PUNCT fnp-5195 24 12 cases case NOUN fnp-5195 24 13 of of ADP fnp-5195 24 14 rhombencephalosynapsis rhombencephalosynapsis NOUN fnp-5195 24 15 demonstrated demonstrate VERB fnp-5195 24 16 as as ADP fnp-5195 24 17 with with ADP fnp-5195 24 18 mes me NOUN fnp-5195 24 19 and and CCONJ fnp-5195 24 20 6 6 NUM fnp-5195 24 21 cases case NOUN fnp-5195 24 22 ( ( PUNCT fnp-5195 24 23 25 25 NUM fnp-5195 24 24 % % NOUN fnp-5195 24 25 ) ) PUNCT fnp-5195 24 26 demonstrated demonstrate VERB fnp-5195 24 27 a a DET fnp-5195 24 28 mass mass NOUN fnp-5195 24 29 of of ADP fnp-5195 24 30 neurons neuron NOUN fnp-5195 24 31 resembling resemble VERB fnp-5195 24 32 heterotopic heterotopic NOUN fnp-5195 24 33 purkinje purkinje PROPN fnp-5195 24 34 cells cell NOUN fnp-5195 24 35 obstructing obstruct VERB fnp-5195 24 36 the the DET fnp-5195 24 37 rostral rostral ADJ fnp-5195 24 38 4th 4th ADJ fnp-5195 24 39 ventricle ventricle NOUN fnp-5195 24 40 / / SYM fnp-5195 24 41 caudal caudal NOUN fnp-5195 24 42 aqueduct aqueduct NOUN fnp-5195 24 43 . . PUNCT fnp-5195 25 1 2 2 X fnp-5195 25 2 . . X fnp-5195 25 3 hemifacial hemifacial ADJ fnp-5195 25 4 hypoplasia hypoplasia NOUN fnp-5195 25 5 : : PUNCT fnp-5195 25 6 we we PRON fnp-5195 25 7 encountered encounter VERB fnp-5195 25 8 7 7 NUM fnp-5195 25 9 cases case NOUN fnp-5195 25 10 of of ADP fnp-5195 25 11 hemifacial hemifacial ADJ fnp-5195 25 12 hypoplasia hypoplasia NOUN fnp-5195 25 13 ( ( PUNCT fnp-5195 25 14 hh hh PROPN fnp-5195 25 15 ) ) PUNCT fnp-5195 25 16 with with ADP fnp-5195 25 17 as as ADP fnp-5195 25 18 and and CCONJ fnp-5195 25 19 mes me NOUN fnp-5195 25 20 . . PUNCT fnp-5195 26 1 on on ADP fnp-5195 26 2 review review NOUN fnp-5195 26 3 of of ADP fnp-5195 26 4 central central ADJ fnp-5195 26 5 nervous nervous ADJ fnp-5195 26 6 system system NOUN fnp-5195 26 7 pathology pathology NOUN fnp-5195 26 8 in in ADP fnp-5195 26 9 hh hh PROPN fnp-5195 26 10 , , PUNCT fnp-5195 26 11 of of ADP fnp-5195 26 12 the the DET fnp-5195 26 13 21 21 NUM fnp-5195 26 14 cases case NOUN fnp-5195 26 15 of of ADP fnp-5195 26 16 hh hh NOUN fnp-5195 26 17 in in ADP fnp-5195 26 18 our our PRON fnp-5195 26 19 archives archive NOUN fnp-5195 26 20 7 7 NUM fnp-5195 26 21 had have VERB fnp-5195 26 22 hydrocephalus hydrocephalus ADJ fnp-5195 26 23 , , PUNCT fnp-5195 26 24 and and CCONJ fnp-5195 26 25 all all DET fnp-5195 26 26 7 7 NUM fnp-5195 26 27 had have VERB fnp-5195 26 28 as as ADP fnp-5195 26 29 and and CCONJ fnp-5195 26 30 mes me NOUN fnp-5195 26 31 , , PUNCT fnp-5195 26 32 including include VERB fnp-5195 26 33 two two NUM fnp-5195 26 34 rhombencephalosynapses rhombencephalosynapse NOUN fnp-5195 26 35 . . PUNCT fnp-5195 27 1 as as ADP fnp-5195 27 2 with with ADP fnp-5195 27 3 mes me NOUN fnp-5195 27 4 seems seem VERB fnp-5195 27 5 to to PART fnp-5195 27 6 be be AUX fnp-5195 27 7 a a DET fnp-5195 27 8 principal principal ADJ fnp-5195 27 9 pathology pathology NOUN fnp-5195 27 10 causing cause VERB fnp-5195 27 11 hydrocephalus hydrocephalus ADV fnp-5195 27 12 in in ADP fnp-5195 27 13 hh hh PROPN fnp-5195 27 14 . . PROPN fnp-5195 27 15 3 3 X fnp-5195 27 16 . . X fnp-5195 27 17 tegmental tegmental ADJ fnp-5195 27 18 injury injury PROPN fnp-5195 27 19 : : PUNCT fnp-5195 27 20 we we PRON fnp-5195 27 21 identified identify VERB fnp-5195 27 22 3 3 NUM fnp-5195 27 23 cases case NOUN fnp-5195 27 24 of of ADP fnp-5195 27 25 symmetrical symmetrical ADJ fnp-5195 27 26 tegmental tegmental ADJ fnp-5195 27 27 injury injury NOUN fnp-5195 27 28 with with ADP fnp-5195 27 29 calcifications calcification NOUN fnp-5195 27 30 and and CCONJ fnp-5195 27 31 microglial microglial ADJ fnp-5195 27 32 aggregates aggregate NOUN fnp-5195 27 33 , , PUNCT fnp-5195 27 34 in in ADP fnp-5195 27 35 a a DET fnp-5195 27 36 pattern pattern NOUN fnp-5195 27 37 suggestive suggestive ADJ fnp-5195 27 38 of of ADP fnp-5195 27 39 fetal fetal ADJ fnp-5195 27 40 hypoxic hypoxic ADV fnp-5195 27 41 ischemic ischemic ADJ fnp-5195 27 42 injury injury NOUN fnp-5195 27 43 . . PUNCT fnp-5195 28 1 two two NUM fnp-5195 28 2 cases case NOUN fnp-5195 28 3 had have VERB fnp-5195 28 4 as as ADP fnp-5195 28 5 with with ADP fnp-5195 28 6 atresia atresia NOUN fnp-5195 28 7 , , PUNCT fnp-5195 28 8 and and CCONJ fnp-5195 28 9 one one NUM fnp-5195 28 10 a a DET fnp-5195 28 11 slit slit NOUN fnp-5195 28 12 like like ADP fnp-5195 28 13 aqueduct aqueduct NOUN fnp-5195 28 14 , , PUNCT fnp-5195 28 15 none none NOUN fnp-5195 28 16 had have VERB fnp-5195 28 17 mes me NOUN fnp-5195 28 18 . . PUNCT fnp-5195 29 1 tegmental tegmental ADJ fnp-5195 29 2 injury injury NOUN fnp-5195 29 3 in in ADP fnp-5195 29 4 a a DET fnp-5195 29 5 hypoxic hypoxic ADV fnp-5195 29 6 ischemic ischemic ADJ fnp-5195 29 7 pattern pattern NOUN fnp-5195 29 8 is be AUX fnp-5195 29 9 an an DET fnp-5195 29 10 infrequent infrequent ADJ fnp-5195 29 11 but but CCONJ fnp-5195 29 12 distinct distinct ADJ fnp-5195 29 13 pattern pattern NOUN fnp-5195 29 14 producing produce VERB fnp-5195 29 15 as as ADP fnp-5195 29 16 and and CCONJ fnp-5195 29 17 hydrocephalus hydrocephalus X fnp-5195 29 18 . . PUNCT fnp-5195 30 1 other other ADJ fnp-5195 30 2 distinctive distinctive ADJ fnp-5195 30 3 pathologies pathology NOUN fnp-5195 30 4 associated associate VERB fnp-5195 30 5 with with ADP fnp-5195 30 6 as as SCONJ fnp-5195 30 7 are be AUX fnp-5195 30 8 the the DET fnp-5195 30 9 vacterl vacterl NOUN fnp-5195 30 10 association association NOUN fnp-5195 30 11 ( ( PUNCT fnp-5195 30 12 2 2 NUM fnp-5195 30 13 with with ADP fnp-5195 30 14 mes me NOUN fnp-5195 30 15 , , PUNCT fnp-5195 30 16 5 5 NUM fnp-5195 30 17 without without ADP fnp-5195 30 18 ) ) PUNCT fnp-5195 30 19 , , PUNCT fnp-5195 30 20 holoprosencephaly holoprosencephaly PROPN fnp-5195 30 21 ( ( PUNCT fnp-5195 30 22 n=8 n=8 PROPN fnp-5195 30 23 ) ) PUNCT fnp-5195 30 24 and and CCONJ fnp-5195 30 25 amniotic amniotic ADJ fnp-5195 30 26 rupture rupture NOUN fnp-5195 30 27 sequence sequence NOUN fnp-5195 30 28 ( ( PUNCT fnp-5195 30 29 n=3 n=3 VERB fnp-5195 30 30 , , PUNCT fnp-5195 30 31 all all PRON fnp-5195 30 32 with with ADP fnp-5195 30 33 mes me NOUN fnp-5195 30 34 ) ) PUNCT fnp-5195 30 35 . . PUNCT fnp-5195 30 36     SPACE fnp-5195 31 1 abstract abstract ADJ fnp-5195 31 2 3 3 NUM fnp-5195 31 3 free free ADJ fnp-5195 31 4 neuropathol neuropathol NOUN fnp-5195 31 5 4:20:6 4:20:6 PRON fnp-5195 31 6 a a DET fnp-5195 31 7 novel novel ADJ fnp-5195 31 8 association association NOUN fnp-5195 31 9 : : PUNCT fnp-5195 31 10 distal distal ADJ fnp-5195 31 11 arthrogryposis arthrogryposis NOUN fnp-5195 31 12 , , PUNCT fnp-5195 31 13 kif21a kif21a PROPN fnp-5195 31 14 and and CCONJ fnp-5195 31 15 fetal fetal ADJ fnp-5195 31 16 neuroaxonal neuroaxonal ADJ fnp-5195 31 17 dystrophy dystrophy NOUN fnp-5195 31 18 leslie leslie PROPN fnp-5195 31 19 e. e. PROPN fnp-5195 31 20 hamilton1 hamilton1 PROPN fnp-5195 31 21 , , PUNCT fnp-5195 31 22 priya priya PROPN fnp-5195 31 23 t. t. PROPN fnp-5195 31 24 bhola2 bhola2 PROPN fnp-5195 31 25 , , PUNCT fnp-5195 31 26 radha radha PROPN fnp-5195 31 27 mishra3 mishra3 PROPN fnp-5195 31 28 , , PUNCT fnp-5195 31 29 gail gail PROPN fnp-5195 31 30 e. e. PROPN fnp-5195 31 31 graham2 graham2 PROPN fnp-5195 31 32 , , PUNCT fnp-5195 31 33 care4rare care4rare VERB fnp-5195 31 34 canada canada PROPN fnp-5195 31 35 consortium4 consortium4 PROPN fnp-5195 31 36 , , PUNCT fnp-5195 31 37 kym kym PROPN fnp-5195 31 38 m. m. PROPN fnp-5195 31 39 boycott2,4 boycott2,4 PROPN fnp-5195 31 40 , , PUNCT fnp-5195 31 41 damien damien PROPN fnp-5195 31 42 d’amours3 d’amours3 PROPN fnp-5195 31 43 , , PUNCT fnp-5195 31 44 kristin kristin PROPN fnp-5195 31 45 d. d. PROPN fnp-5195 31 46 kernohan4,5 kernohan4,5 PROPN fnp-5195 31 47 1 1 NUM fnp-5195 31 48 department department NOUN fnp-5195 31 49 of of ADP fnp-5195 31 50 pathology pathology NOUN fnp-5195 31 51 and and CCONJ fnp-5195 31 52 laboratory laboratory NOUN fnp-5195 31 53 medicine medicine NOUN fnp-5195 31 54 , , PUNCT fnp-5195 31 55 children child NOUN fnp-5195 31 56 ’s ’s PART fnp-5195 31 57 hospital hospital NOUN fnp-5195 31 58 of of ADP fnp-5195 31 59 eastern eastern PROPN fnp-5195 31 60 ontario ontario PROPN fnp-5195 31 61 and and CCONJ fnp-5195 31 62 university university PROPN fnp-5195 31 63 of of ADP fnp-5195 31 64 ottawa ottawa PROPN fnp-5195 31 65 , , PUNCT fnp-5195 31 66 ottawa ottawa PROPN fnp-5195 31 67 , , PUNCT fnp-5195 31 68 canada canada PROPN fnp-5195 31 69 2 2 NUM fnp-5195 31 70 department department NOUN fnp-5195 31 71 of of ADP fnp-5195 31 72 genetics genetic NOUN fnp-5195 31 73 , , PUNCT fnp-5195 31 74 children child NOUN fnp-5195 31 75 ’s ’s PART fnp-5195 31 76 hospital hospital NOUN fnp-5195 31 77 of of ADP fnp-5195 31 78 eastern eastern PROPN fnp-5195 31 79 ontario ontario PROPN fnp-5195 31 80 , , PUNCT fnp-5195 31 81 ottawa ottawa PROPN fnp-5195 31 82 , , PUNCT fnp-5195 31 83 canada canada PROPN fnp-5195 31 84 3 3 NUM fnp-5195 31 85 department department NOUN fnp-5195 31 86 of of ADP fnp-5195 31 87 cellular cellular ADJ fnp-5195 31 88 and and CCONJ fnp-5195 31 89 molecular molecular ADJ fnp-5195 31 90 medicine medicine NOUN fnp-5195 31 91 , , PUNCT fnp-5195 31 92 ottawa ottawa PROPN fnp-5195 31 93 institute institute PROPN fnp-5195 31 94 of of ADP fnp-5195 31 95 systems systems PROPN fnp-5195 31 96 biology biology NOUN fnp-5195 31 97 , , PUNCT fnp-5195 31 98 university university NOUN fnp-5195 31 99 of of ADP fnp-5195 31 100 ottawa ottawa PROPN fnp-5195 31 101 , , PUNCT fnp-5195 31 102 ottawa ottawa PROPN fnp-5195 31 103 , , PUNCT fnp-5195 31 104 canada canada PROPN fnp-5195 31 105 4 4 NUM fnp-5195 31 106 children child NOUN fnp-5195 31 107 ’s ’s PART fnp-5195 31 108 hospital hospital NOUN fnp-5195 31 109 of of ADP fnp-5195 31 110 eastern eastern PROPN fnp-5195 31 111 ontario ontario PROPN fnp-5195 31 112 research research PROPN fnp-5195 31 113 institute institute PROPN fnp-5195 31 114 , , PUNCT fnp-5195 31 115 university university PROPN fnp-5195 31 116 of of ADP fnp-5195 31 117 ottawa ottawa PROPN fnp-5195 31 118 , , PUNCT fnp-5195 31 119 ottawa ottawa PROPN fnp-5195 31 120 , , PUNCT fnp-5195 31 121 canada canada PROPN fnp-5195 31 122 5 5 NUM fnp-5195 31 123 newborn newborn ADJ fnp-5195 31 124 screening screen VERB fnp-5195 31 125 ontario ontario PROPN fnp-5195 31 126 ( ( PUNCT fnp-5195 31 127 nso nso PROPN fnp-5195 31 128 ) ) PUNCT fnp-5195 31 129 , , PUNCT fnp-5195 31 130 ottawa ottawa PROPN fnp-5195 31 131 , , PUNCT fnp-5195 31 132 canada canada PROPN fnp-5195 31 133 although although SCONJ fnp-5195 31 134 fetal fetal ADJ fnp-5195 31 135 neuroaxonal neuroaxonal ADJ fnp-5195 31 136 dystrophy dystrophy NOUN fnp-5195 31 137 is be AUX fnp-5195 31 138 an an DET fnp-5195 31 139 established establish VERB fnp-5195 31 140 etiology etiology NOUN fnp-5195 31 141 for for ADP fnp-5195 31 142 fetal fetal ADJ fnp-5195 31 143 akinesia akinesia NOUN fnp-5195 31 144 , , PUNCT fnp-5195 31 145 the the DET fnp-5195 31 146 underlying underlie VERB fnp-5195 31 147 genetics genetic NOUN fnp-5195 31 148 were be AUX fnp-5195 31 149 not not PART fnp-5195 31 150 known know VERB fnp-5195 31 151 . . PUNCT fnp-5195 32 1 kif21a kif21a PROPN fnp-5195 32 2 is be AUX fnp-5195 32 3 a a DET fnp-5195 32 4 kinesin kinesin NOUN fnp-5195 32 5 motor motor NOUN fnp-5195 32 6 protein protein NOUN fnp-5195 32 7 that that PRON fnp-5195 32 8 plays play VERB fnp-5195 32 9 an an DET fnp-5195 32 10 important important ADJ fnp-5195 32 11 role role NOUN fnp-5195 32 12 in in ADP fnp-5195 32 13 microtubule microtubule NOUN fnp-5195 32 14 dynamics dynamic NOUN fnp-5195 32 15 , , PUNCT fnp-5195 32 16 including include VERB fnp-5195 32 17 regulation regulation NOUN fnp-5195 32 18 of of ADP fnp-5195 32 19 axonal axonal ADJ fnp-5195 32 20 growth growth NOUN fnp-5195 32 21 . . PUNCT fnp-5195 33 1 recently recently ADV fnp-5195 33 2 , , PUNCT fnp-5195 33 3 falk falk NOUN fnp-5195 33 4 et et NOUN fnp-5195 33 5 al al PROPN fnp-5195 33 6 . . PROPN fnp-5195 33 7 ( ( PUNCT fnp-5195 33 8 2023 2023 NUM fnp-5195 33 9 ) ) PUNCT fnp-5195 33 10 linked link VERB fnp-5195 33 11 bi bi ADJ fnp-5195 33 12 - - ADJ fnp-5195 33 13 allelic allelic ADJ fnp-5195 33 14 loss loss NOUN fnp-5195 33 15 - - PUNCT fnp-5195 33 16 of of ADP fnp-5195 33 17 - - PUNCT fnp-5195 33 18 function function NOUN fnp-5195 33 19 variants variant NOUN fnp-5195 33 20 in in ADP fnp-5195 33 21 kif21a kif21a PROPN fnp-5195 33 22 to to ADP fnp-5195 33 23 severe severe ADJ fnp-5195 33 24 fetal fetal ADJ fnp-5195 33 25 akinesia akinesia NOUN fnp-5195 33 26 with with ADP fnp-5195 33 27 arthrogryposis arthrogryposis NOUN fnp-5195 33 28 . . PUNCT fnp-5195 34 1 we we PRON fnp-5195 34 2 present present VERB fnp-5195 34 3 the the DET fnp-5195 34 4 case case NOUN fnp-5195 34 5 of of ADP fnp-5195 34 6 an an DET fnp-5195 34 7 young young ADJ fnp-5195 34 8 infant infant NOUN fnp-5195 34 9 diagnosed diagnose VERB fnp-5195 34 10 in in ADP fnp-5195 34 11 utero utero NOUN fnp-5195 34 12 with with ADP fnp-5195 34 13 distal distal ADJ fnp-5195 34 14 arthrogryposis arthrogryposis NOUN fnp-5195 34 15 , , PUNCT fnp-5195 34 16 who who PRON fnp-5195 34 17 died die VERB fnp-5195 34 18 at at ADP fnp-5195 34 19 3 3 NUM fnp-5195 34 20 weeks week NOUN fnp-5195 34 21 of of ADP fnp-5195 34 22 age age NOUN fnp-5195 34 23 , , PUNCT fnp-5195 34 24 that that PRON fnp-5195 34 25 represents represent VERB fnp-5195 34 26 an an DET fnp-5195 34 27 independent independent ADJ fnp-5195 34 28 discovery discovery NOUN fnp-5195 34 29 of of ADP fnp-5195 34 30 this this DET fnp-5195 34 31 autosomal autosomal ADJ fnp-5195 34 32 recessive recessive ADJ fnp-5195 34 33 kif21a kif21a ADV fnp-5195 34 34 - - PUNCT fnp-5195 34 35 related relate VERB fnp-5195 34 36 condition condition NOUN fnp-5195 34 37 . . PUNCT fnp-5195 35 1 her her PRON fnp-5195 35 2 course course NOUN fnp-5195 35 3 was be AUX fnp-5195 35 4 complicated complicate VERB fnp-5195 35 5 by by ADP fnp-5195 35 6 respiratory respiratory ADJ fnp-5195 35 7 issues issue NOUN fnp-5195 35 8 , , PUNCT fnp-5195 35 9 hypotonia hypotonia NOUN fnp-5195 35 10 , , PUNCT fnp-5195 35 11 seizures seizure NOUN fnp-5195 35 12 and and CCONJ fnp-5195 35 13 neurological neurological ADJ fnp-5195 35 14 deterioration deterioration NOUN fnp-5195 35 15 . . PUNCT fnp-5195 36 1 brain brain NOUN fnp-5195 36 2 mri mri NOUN fnp-5195 36 3 was be AUX fnp-5195 36 4 significant significant ADJ fnp-5195 36 5 for for ADP fnp-5195 36 6 polymicrogyria polymicrogyria NOUN fnp-5195 36 7 , , PUNCT fnp-5195 36 8 diffuse diffuse ADJ fnp-5195 36 9 brain brain NOUN fnp-5195 36 10 volume volume NOUN fnp-5195 36 11 loss loss NOUN fnp-5195 36 12 and and CCONJ fnp-5195 36 13 mild mild ADJ fnp-5195 36 14 thinning thinning NOUN fnp-5195 36 15 of of ADP fnp-5195 36 16 optic optic ADJ fnp-5195 36 17 nerves nerve NOUN fnp-5195 36 18 . . PUNCT fnp-5195 37 1 autopsy autopsy ADJ fnp-5195 37 2 findings finding NOUN fnp-5195 37 3 confirmed confirm VERB fnp-5195 37 4 the the DET fnp-5195 37 5 bilateral bilateral ADJ fnp-5195 37 6 extensive extensive ADJ fnp-5195 37 7 polymicrogyria polymicrogyria NOUN fnp-5195 37 8 and and CCONJ fnp-5195 37 9 reduced reduce VERB fnp-5195 37 10 brain brain NOUN fnp-5195 37 11 volume volume NOUN fnp-5195 37 12 , , PUNCT fnp-5195 37 13 with with ADP fnp-5195 37 14 probable probable ADJ fnp-5195 37 15 thinning thinning NOUN fnp-5195 37 16 of of ADP fnp-5195 37 17 the the DET fnp-5195 37 18 corpus corpus NOUN fnp-5195 37 19 callosum callosum NOUN fnp-5195 37 20 and and CCONJ fnp-5195 37 21 descending descend VERB fnp-5195 37 22 corticospinal corticospinal ADJ fnp-5195 37 23 tracts tract NOUN fnp-5195 37 24 . . PUNCT fnp-5195 38 1 histologically histologically ADV fnp-5195 38 2 , , PUNCT fnp-5195 38 3 axonal axonal ADJ fnp-5195 38 4 spheroids spheroid NOUN fnp-5195 38 5 were be AUX fnp-5195 38 6 seen see VERB fnp-5195 38 7 throughout throughout ADP fnp-5195 38 8 multiple multiple ADJ fnp-5195 38 9 regions region NOUN fnp-5195 38 10 of of ADP fnp-5195 38 11 the the DET fnp-5195 38 12 central central ADJ fnp-5195 38 13 and and CCONJ fnp-5195 38 14 peripheral peripheral ADJ fnp-5195 38 15 nervous nervous ADJ fnp-5195 38 16 system system NOUN fnp-5195 38 17 . . PUNCT fnp-5195 39 1 other other ADJ fnp-5195 39 2 findings finding NOUN fnp-5195 39 3 included include VERB fnp-5195 39 4 cerebellar cerebellar ADJ fnp-5195 39 5 heterotopia heterotopia NOUN fnp-5195 39 6 , , PUNCT fnp-5195 39 7 simplification simplification NOUN fnp-5195 39 8 of of ADP fnp-5195 39 9 the the DET fnp-5195 39 10 inferior inferior ADJ fnp-5195 39 11 olives olive NOUN fnp-5195 39 12 and and CCONJ fnp-5195 39 13 a a DET fnp-5195 39 14 congenital congenital ADJ fnp-5195 39 15 neurogenic neurogenic ADJ fnp-5195 39 16 myopathy myopathy NOUN fnp-5195 39 17 . . PUNCT fnp-5195 40 1 clinical clinical ADJ fnp-5195 40 2 exome exome NOUN fnp-5195 40 3 sequencing sequence VERB fnp-5195 40 4 revealed reveal VERB fnp-5195 40 5 biallelic biallelic ADJ fnp-5195 40 6 compound compound VERB fnp-5195 40 7 heterozygous heterozygous ADJ fnp-5195 40 8 variants variant NOUN fnp-5195 40 9 in in ADP fnp-5195 40 10 kif21a kif21a PROPN fnp-5195 40 11 . . PUNCT fnp-5195 41 1 our our PRON fnp-5195 41 2 case case NOUN fnp-5195 41 3 represents represent VERB fnp-5195 41 4 an an DET fnp-5195 41 5 independent independent ADJ fnp-5195 41 6 discovery discovery NOUN fnp-5195 41 7 and and CCONJ fnp-5195 41 8 second second ADJ fnp-5195 41 9 report report NOUN fnp-5195 41 10 of of ADP fnp-5195 41 11 the the DET fnp-5195 41 12 autosomal autosomal ADJ fnp-5195 41 13 recessive recessive ADJ fnp-5195 41 14 condition condition NOUN fnp-5195 41 15 related relate VERB fnp-5195 41 16 to to ADP fnp-5195 41 17 kif21a kif21a PROPN fnp-5195 41 18 and and CCONJ fnp-5195 41 19 revealed reveal VERB fnp-5195 41 20 fetal fetal ADJ fnp-5195 41 21 neuroaxonal neuroaxonal ADJ fnp-5195 41 22 dystrophy dystrophy NOUN fnp-5195 41 23 as as ADP fnp-5195 41 24 the the DET fnp-5195 41 25 underlying underlying ADJ fnp-5195 41 26 neuropathology neuropathology NOUN fnp-5195 41 27 , , PUNCT fnp-5195 41 28 which which PRON fnp-5195 41 29 has have AUX fnp-5195 41 30 not not PART fnp-5195 41 31 been be AUX fnp-5195 41 32 previously previously ADV fnp-5195 41 33 described describe VERB fnp-5195 41 34 in in ADP fnp-5195 41 35 the the DET fnp-5195 41 36 literature literature NOUN fnp-5195 41 37 . . PUNCT fnp-5195 42 1 our our PRON fnp-5195 42 2 findings finding NOUN fnp-5195 42 3 expand expand VERB fnp-5195 42 4 the the DET fnp-5195 42 5 spectrum spectrum NOUN fnp-5195 42 6 of of ADP fnp-5195 42 7 kif21a kif21a PROPN fnp-5195 42 8 - - PUNCT fnp-5195 42 9 related relate VERB fnp-5195 42 10 disorders disorder NOUN fnp-5195 42 11 , , PUNCT fnp-5195 42 12 and and CCONJ fnp-5195 42 13 highlight highlight VERB fnp-5195 42 14 the the DET fnp-5195 42 15 importance importance NOUN fnp-5195 42 16 of of ADP fnp-5195 42 17 a a DET fnp-5195 42 18 multidisciplinary multidisciplinary ADJ fnp-5195 42 19 approach approach NOUN fnp-5195 42 20 , , PUNCT fnp-5195 42 21 exome exome NOUN fnp-5195 42 22 sequencing sequencing NOUN fnp-5195 42 23 , , PUNCT fnp-5195 42 24 and and CCONJ fnp-5195 42 25 multi multi ADJ fnp-5195 42 26 - - ADJ fnp-5195 42 27 site site ADJ fnp-5195 42 28 collaboration collaboration NOUN fnp-5195 42 29 in in ADP fnp-5195 42 30 the the DET fnp-5195 42 31 investigation investigation NOUN fnp-5195 42 32 of of ADP fnp-5195 42 33 rare rare ADJ fnp-5195 42 34 genetic genetic ADJ fnp-5195 42 35 conditions condition NOUN fnp-5195 42 36 . . PUNCT fnp-5195 42 37     SPACE fnp-5195 43 1 abstract abstract ADJ fnp-5195 43 2 4 4 NUM fnp-5195 43 3 free free ADJ fnp-5195 43 4 neuropathol neuropathol NOUN fnp-5195 43 5 4:20:7 4:20:7 NUM fnp-5195 43 6 polymicrogyria polymicrogyria NOUN fnp-5195 43 7 through through ADP fnp-5195 43 8 a a DET fnp-5195 43 9 tensegrity tensegrity NOUN fnp-5195 43 10 lens lens NOUN fnp-5195 43 11 robert robert PROPN fnp-5195 43 12 hammond1 hammond1 PROPN fnp-5195 43 13 , , PUNCT fnp-5195 43 14 christopher christopher PROPN fnp-5195 43 15 dunham2 dunham2 PROPN fnp-5195 43 16 1 1 NUM fnp-5195 43 17 department department NOUN fnp-5195 43 18 of of ADP fnp-5195 43 19 pathology pathology NOUN fnp-5195 43 20 and and CCONJ fnp-5195 43 21 laboratory laboratory NOUN fnp-5195 43 22 medicine medicine NOUN fnp-5195 43 23 , , PUNCT fnp-5195 43 24 western western ADJ fnp-5195 43 25 university university NOUN fnp-5195 43 26 , , PUNCT fnp-5195 43 27 london london PROPN fnp-5195 43 28 , , PUNCT fnp-5195 43 29 ontario ontario PROPN fnp-5195 43 30 , , PUNCT fnp-5195 43 31 canada canada PROPN fnp-5195 43 32 2 2 NUM fnp-5195 43 33 department department NOUN fnp-5195 43 34 of of ADP fnp-5195 43 35 pathology pathology NOUN fnp-5195 43 36 and and CCONJ fnp-5195 43 37 laboratory laboratory NOUN fnp-5195 43 38 medicine medicine NOUN fnp-5195 43 39 , , PUNCT fnp-5195 43 40 university university NOUN fnp-5195 43 41 of of ADP fnp-5195 43 42 british british PROPN fnp-5195 43 43 columbia columbia PROPN fnp-5195 43 44 , , PUNCT fnp-5195 43 45 vancouver vancouver PROPN fnp-5195 43 46 , , PUNCT fnp-5195 43 47 british british PROPN fnp-5195 43 48 columbia columbia PROPN fnp-5195 43 49 , , PUNCT fnp-5195 43 50 canada canada PROPN fnp-5195 43 51 polymicrogyria polymicrogyria PROPN fnp-5195 43 52 is be AUX fnp-5195 43 53 an an DET fnp-5195 43 54 anomaly anomaly NOUN fnp-5195 43 55 of of ADP fnp-5195 43 56 cortical cortical ADJ fnp-5195 43 57 development development NOUN fnp-5195 43 58 . . PUNCT fnp-5195 44 1 it it PRON fnp-5195 44 2 may may AUX fnp-5195 44 3 be be AUX fnp-5195 44 4 pure pure ADJ fnp-5195 44 5 or or CCONJ fnp-5195 44 6 associated associate VERB fnp-5195 44 7 with with ADP fnp-5195 44 8 other other ADJ fnp-5195 44 9 lesions lesion NOUN fnp-5195 44 10 . . PUNCT fnp-5195 45 1 polymicrogyria polymicrogyria NOUN fnp-5195 45 2 is be AUX fnp-5195 45 3 etiologically etiologically ADV fnp-5195 45 4 diverse diverse ADJ fnp-5195 45 5 and and CCONJ fnp-5195 45 6 associated associate VERB fnp-5195 45 7 with with ADP fnp-5195 45 8 a a DET fnp-5195 45 9 spectrum spectrum NOUN fnp-5195 45 10 of of ADP fnp-5195 45 11 neurological neurological ADJ fnp-5195 45 12 consequences consequence NOUN fnp-5195 45 13 proportional proportional ADJ fnp-5195 45 14 to to ADP fnp-5195 45 15 its its PRON fnp-5195 45 16 extent extent NOUN fnp-5195 45 17 and and CCONJ fnp-5195 45 18 associated associated ADJ fnp-5195 45 19 abnormalities abnormality NOUN fnp-5195 45 20 . . PUNCT fnp-5195 46 1 the the DET fnp-5195 46 2 literature literature NOUN fnp-5195 46 3 has have AUX fnp-5195 46 4 mediated mediate VERB fnp-5195 46 5 a a DET fnp-5195 46 6 debate debate NOUN fnp-5195 46 7 on on ADP fnp-5195 46 8 the the DET fnp-5195 46 9 timing timing NOUN fnp-5195 46 10 and and CCONJ fnp-5195 46 11 significance significance NOUN fnp-5195 46 12 of of ADP fnp-5195 46 13 particular particular ADJ fnp-5195 46 14 etiologies etiology NOUN fnp-5195 46 15 , , PUNCT fnp-5195 46 16 inviting invite VERB fnp-5195 46 17 a a DET fnp-5195 46 18 variety variety NOUN fnp-5195 46 19 of of ADP fnp-5195 46 20 theories theory NOUN fnp-5195 46 21 to to PART fnp-5195 46 22 account account VERB fnp-5195 46 23 for for ADP fnp-5195 46 24 its its PRON fnp-5195 46 25 stereotypic stereotypic ADJ fnp-5195 46 26 architecture architecture NOUN fnp-5195 46 27 . . PUNCT fnp-5195 47 1 congenital congenital ADJ fnp-5195 47 2 cytomegalovirus cytomegalovirus NOUN fnp-5195 47 3 ( ( PUNCT fnp-5195 47 4 cmv cmv NOUN fnp-5195 47 5 ) ) PUNCT fnp-5195 47 6 infection infection NOUN fnp-5195 47 7 is be AUX fnp-5195 47 8 a a DET fnp-5195 47 9 common common ADJ fnp-5195 47 10 cause cause NOUN fnp-5195 47 11 of of ADP fnp-5195 47 12 polymicrogyria polymicrogyria NOUN fnp-5195 47 13 . . PUNCT fnp-5195 48 1 in in ADP fnp-5195 48 2 a a DET fnp-5195 48 3 collection collection NOUN fnp-5195 48 4 of of ADP fnp-5195 48 5 such such ADJ fnp-5195 48 6 cases case NOUN fnp-5195 48 7 , , PUNCT fnp-5195 48 8 ranging range VERB fnp-5195 48 9 from from ADP fnp-5195 48 10 16 16 NUM fnp-5195 48 11 to to PART fnp-5195 48 12 39 39 NUM fnp-5195 48 13 weeks week NOUN fnp-5195 48 14 gestational gestational ADJ fnp-5195 48 15 age age NOUN fnp-5195 48 16 , , PUNCT fnp-5195 48 17 several several ADJ fnp-5195 48 18 findings finding NOUN fnp-5195 48 19 were be AUX fnp-5195 48 20 almost almost ADV fnp-5195 48 21 invariable invariable ADJ fnp-5195 48 22 : : PUNCT fnp-5195 48 23 subventricular subventricular ADJ fnp-5195 48 24 zone zone NOUN fnp-5195 48 25 necrosis necrosis NOUN fnp-5195 48 26 , , PUNCT fnp-5195 48 27 subventricular subventricular ADJ fnp-5195 48 28 germinal germinal ADJ fnp-5195 48 29 cell cell NOUN fnp-5195 48 30 infection infection NOUN fnp-5195 48 31 , , PUNCT fnp-5195 48 32 radial radial ADJ fnp-5195 48 33 glial glial ADJ fnp-5195 48 34 disruption disruption NOUN fnp-5195 48 35 and and CCONJ fnp-5195 48 36 injuries injury NOUN fnp-5195 48 37 to to ADP fnp-5195 48 38 the the DET fnp-5195 48 39 pial pial ADJ fnp-5195 48 40 - - PUNCT fnp-5195 48 41 glial glial ADJ fnp-5195 48 42 border border NOUN fnp-5195 48 43 . . PUNCT fnp-5195 49 1 subcortical subcortical ADJ fnp-5195 49 2 neuronal neuronal ADJ fnp-5195 49 3 heterotopias heterotopia NOUN fnp-5195 49 4 and and CCONJ fnp-5195 49 5 leptomeningeal leptomeningeal ADJ fnp-5195 49 6 heterotopias heterotopia NOUN fnp-5195 49 7 were be AUX fnp-5195 49 8 also also ADV fnp-5195 49 9 common common ADJ fnp-5195 49 10 . . PUNCT fnp-5195 50 1 clinical clinical ADJ fnp-5195 50 2 details detail NOUN fnp-5195 50 3 and and CCONJ fnp-5195 50 4 pathological pathological ADJ fnp-5195 50 5 findings finding NOUN fnp-5195 50 6 indicate indicate VERB fnp-5195 50 7 that that SCONJ fnp-5195 50 8 the the DET fnp-5195 50 9 responsible responsible ADJ fnp-5195 50 10 insults insult NOUN fnp-5195 50 11 occurred occur VERB fnp-5195 50 12 before before ADP fnp-5195 50 13 neuronal neuronal ADJ fnp-5195 50 14 migration migration NOUN fnp-5195 50 15 was be AUX fnp-5195 50 16 complete complete ADJ fnp-5195 50 17 , , PUNCT fnp-5195 50 18 lasted last VERB fnp-5195 50 19 several several ADJ fnp-5195 50 20 weeks week NOUN fnp-5195 50 21 and and CCONJ fnp-5195 50 22 led lead VERB fnp-5195 50 23 to to ADP fnp-5195 50 24 a a DET fnp-5195 50 25 variety variety NOUN fnp-5195 50 26 of of ADP fnp-5195 50 27 structural structural ADJ fnp-5195 50 28 perturbations perturbation NOUN fnp-5195 50 29 to to ADP fnp-5195 50 30 the the DET fnp-5195 50 31 developing develop VERB fnp-5195 50 32 brain brain NOUN fnp-5195 50 33 . . PUNCT fnp-5195 51 1 these these DET fnp-5195 51 2 cases case NOUN fnp-5195 51 3 add add VERB fnp-5195 51 4 to to ADP fnp-5195 51 5 the the DET fnp-5195 51 6 evidence evidence NOUN fnp-5195 51 7 that that SCONJ fnp-5195 51 8 polymicrogyria polymicrogyria NOUN fnp-5195 51 9 is be AUX fnp-5195 51 10 not not PART fnp-5195 51 11 solely solely ADV fnp-5195 51 12 post post ADJ fnp-5195 51 13 - - ADJ fnp-5195 51 14 migrational migrational ADJ fnp-5195 51 15 and and CCONJ fnp-5195 51 16 that that SCONJ fnp-5195 51 17 a a DET fnp-5195 51 18 variety variety NOUN fnp-5195 51 19 of of ADP fnp-5195 51 20 injuries injury NOUN fnp-5195 51 21 ( ( PUNCT fnp-5195 51 22 and and CCONJ fnp-5195 51 23 timings timing NOUN fnp-5195 51 24 ) ) PUNCT fnp-5195 51 25 can can AUX fnp-5195 51 26 replicate replicate VERB fnp-5195 51 27 its its PRON fnp-5195 51 28 relatively relatively ADV fnp-5195 51 29 stereotyped stereotype VERB fnp-5195 51 30 morphology morphology NOUN fnp-5195 51 31 . . PUNCT fnp-5195 52 1 a a DET fnp-5195 52 2 reductionist reductionist ADJ fnp-5195 52 3 focus focus NOUN fnp-5195 52 4 on on ADP fnp-5195 52 5 timing timing NOUN fnp-5195 52 6 and and CCONJ fnp-5195 52 7 etiology etiology NOUN fnp-5195 52 8 has have AUX fnp-5195 52 9 distracted distract VERB fnp-5195 52 10 from from ADP fnp-5195 52 11 a a DET fnp-5195 52 12 more more ADV fnp-5195 52 13 fundamental fundamental ADJ fnp-5195 52 14 and and CCONJ fnp-5195 52 15 versatile versatile ADJ fnp-5195 52 16 construct construct NOUN fnp-5195 52 17 built build VERB fnp-5195 52 18 on on ADP fnp-5195 52 19 the the DET fnp-5195 52 20 principles principle NOUN fnp-5195 52 21 of of ADP fnp-5195 52 22 tensegrity tensegrity NOUN fnp-5195 52 23 , , PUNCT fnp-5195 52 24 whereby whereby SCONJ fnp-5195 52 25 the the DET fnp-5195 52 26 brain brain NOUN fnp-5195 52 27 ’s ’s PART fnp-5195 52 28 unique unique ADJ fnp-5195 52 29 morphology morphology NOUN fnp-5195 52 30 ( ( PUNCT fnp-5195 52 31 and and CCONJ fnp-5195 52 32 disruptions disruption NOUN fnp-5195 52 33 of of ADP fnp-5195 52 34 the the DET fnp-5195 52 35 same same ADJ fnp-5195 52 36 ) ) PUNCT fnp-5195 52 37 can can AUX fnp-5195 52 38 be be AUX fnp-5195 52 39 explained explain VERB fnp-5195 52 40 on on ADP fnp-5195 52 41 the the DET fnp-5195 52 42 basis basis NOUN fnp-5195 52 43 of of ADP fnp-5195 52 44 forces force NOUN fnp-5195 52 45 that that PRON fnp-5195 52 46 exist exist VERB fnp-5195 52 47 at at ADP fnp-5195 52 48 the the DET fnp-5195 52 49 tissue tissue NOUN fnp-5195 52 50 , , PUNCT fnp-5195 52 51 cellular cellular ADJ fnp-5195 52 52 and and CCONJ fnp-5195 52 53 subcellular subcellular ADJ fnp-5195 52 54 levels level NOUN fnp-5195 52 55 . . PUNCT fnp-5195 53 1 the the DET fnp-5195 53 2 natural natural ADJ fnp-5195 53 3 experiment experiment NOUN fnp-5195 53 4 of of ADP fnp-5195 53 5 polymicrogyria polymicrogyria NOUN fnp-5195 53 6 in in ADP fnp-5195 53 7 congenital congenital ADJ fnp-5195 53 8 cmv cmv NOUN fnp-5195 53 9 infection infection NOUN fnp-5195 53 10 lends lend VERB fnp-5195 53 11 support support NOUN fnp-5195 53 12 for for ADP fnp-5195 53 13 tensegrity tensegrity NOUN fnp-5195 53 14 as as ADP fnp-5195 53 15 a a DET fnp-5195 53 16 basis basis NOUN fnp-5195 53 17 for for ADP fnp-5195 53 18 normal normal ADJ fnp-5195 53 19 and and CCONJ fnp-5195 53 20 abnormal abnormal ADJ fnp-5195 53 21 morphologies morphology NOUN fnp-5195 53 22 while while SCONJ fnp-5195 53 23 embracing embrace VERB fnp-5195 53 24 the the DET fnp-5195 53 25 variables variable NOUN fnp-5195 53 26 of of ADP fnp-5195 53 27 timing timing NOUN fnp-5195 53 28 and and CCONJ fnp-5195 53 29 etiology etiology NOUN fnp-5195 53 30 . . PUNCT fnp-5195 53 31     SPACE fnp-5195 54 1 abstract abstract ADJ fnp-5195 54 2 5 5 NUM fnp-5195 54 3 free free ADJ fnp-5195 54 4 neuropathol neuropathol NOUN fnp-5195 54 5 4:20:8 4:20:8 NUM fnp-5195 54 6 imaging image VERB fnp-5195 54 7 axonal axonal ADJ fnp-5195 54 8 pathology pathology NOUN fnp-5195 54 9 in in ADP fnp-5195 54 10 the the DET fnp-5195 54 11 retina retina NOUN fnp-5195 54 12 as as ADP fnp-5195 54 13 a a DET fnp-5195 54 14 potential potential ADJ fnp-5195 54 15 non non ADJ fnp-5195 54 16 - - ADJ fnp-5195 54 17 invasive invasive ADJ fnp-5195 54 18 biomarker biomarker NOUN fnp-5195 54 19 for for ADP fnp-5195 54 20 amyotrophic amyotrophic ADJ fnp-5195 54 21 lateral lateral ADJ fnp-5195 54 22 sclerosis sclerosis NOUN fnp-5195 54 23 farbod farbod PROPN fnp-5195 54 24 khorrami1,2 khorrami1,2 PROPN fnp-5195 54 25 * * PROPN fnp-5195 54 26 , , PUNCT fnp-5195 54 27 maryam maryam PROPN fnp-5195 54 28 amin amin PROPN fnp-5195 54 29 mohammed mohammed PROPN fnp-5195 54 30 amin1 amin1 PROPN fnp-5195 54 31 * * PROPN fnp-5195 54 32 , , PUNCT fnp-5195 54 33 xun xun PROPN fnp-5195 54 34 zhou1 zhou1 PROPN fnp-5195 54 35 , , PUNCT fnp-5195 54 36 you you PRON fnp-5195 54 37 liang4 liang4 VERB fnp-5195 54 38 , , PUNCT fnp-5195 54 39 neeru neeru NOUN fnp-5195 54 40 gupta1,2,3,5 gupta1,2,3,5 PROPN fnp-5195 54 41 , , PUNCT fnp-5195 54 42 yeni yeni PROPN fnp-5195 54 43 h. h. PROPN fnp-5195 54 44 yucel1,2,3,5,6 yucel1,2,3,5,6 PROPN fnp-5195 54 45 1 1 NUM fnp-5195 54 46 keenan keenan PROPN fnp-5195 54 47 research research NOUN fnp-5195 54 48 centre centre PROPN fnp-5195 54 49 for for ADP fnp-5195 54 50 biomedical biomedical ADJ fnp-5195 54 51 science science NOUN fnp-5195 54 52 , , PUNCT fnp-5195 54 53 unity unity NOUN fnp-5195 54 54 health health PROPN fnp-5195 54 55 toronto toronto PROPN fnp-5195 54 56 . . PROPN fnp-5195 54 57 st st PROPN fnp-5195 54 58 . . PROPN fnp-5195 54 59 michael michael PROPN fnp-5195 54 60 's 's PART fnp-5195 54 61 hospital hospital PROPN fnp-5195 54 62 , , PUNCT fnp-5195 54 63 toronto toronto PROPN fnp-5195 54 64 , , PUNCT fnp-5195 54 65 on on ADV fnp-5195 54 66 , , PUNCT fnp-5195 54 67 canada canada PROPN fnp-5195 54 68 2 2 NUM fnp-5195 54 69 department department NOUN fnp-5195 54 70 of of ADP fnp-5195 54 71 laboratory laboratory PROPN fnp-5195 54 72 medicine medicine PROPN fnp-5195 54 73 & & CCONJ fnp-5195 54 74 pathobiology pathobiology NOUN fnp-5195 54 75 , , PUNCT fnp-5195 54 76 temerty temerty NOUN fnp-5195 54 77 faculty faculty NOUN fnp-5195 54 78 of of ADP fnp-5195 54 79 medicine medicine NOUN fnp-5195 54 80 , , PUNCT fnp-5195 54 81 university university PROPN fnp-5195 54 82 of of ADP fnp-5195 54 83 toronto toronto PROPN fnp-5195 54 84 , , PUNCT fnp-5195 54 85 toronto toronto PROPN fnp-5195 54 86 , , PUNCT fnp-5195 54 87 on on ADP fnp-5195 54 88 , , PUNCT fnp-5195 54 89 canada canada PROPN fnp-5195 54 90 3 3 NUM fnp-5195 54 91 department department PROPN fnp-5195 54 92 of of ADP fnp-5195 54 93 ophthalmology ophthalmology PROPN fnp-5195 54 94 & & CCONJ fnp-5195 54 95 vision vision PROPN fnp-5195 54 96 sciences sciences PROPN fnp-5195 54 97 , , PUNCT fnp-5195 54 98 temerty temerty NOUN fnp-5195 54 99 faculty faculty NOUN fnp-5195 54 100 of of ADP fnp-5195 54 101 medicine medicine NOUN fnp-5195 54 102 , , PUNCT fnp-5195 54 103 university university PROPN fnp-5195 54 104 of of ADP fnp-5195 54 105 toronto toronto PROPN fnp-5195 54 106 , , PUNCT fnp-5195 54 107 toronto toronto PROPN fnp-5195 54 108 , , PUNCT fnp-5195 54 109 on on ADV fnp-5195 54 110 , , PUNCT fnp-5195 54 111 canada canada PROPN fnp-5195 54 112 4 4 NUM fnp-5195 54 113 department department NOUN fnp-5195 54 114 of of ADP fnp-5195 54 115 mathematics mathematics PROPN fnp-5195 54 116 , , PUNCT fnp-5195 54 117 toronto toronto PROPN fnp-5195 54 118 metropolitan metropolitan PROPN fnp-5195 54 119 university university PROPN fnp-5195 54 120 , , PUNCT fnp-5195 54 121 toronto toronto PROPN fnp-5195 54 122 , , PUNCT fnp-5195 54 123 on on ADV fnp-5195 54 124 , , PUNCT fnp-5195 54 125 canada canada PROPN fnp-5195 54 126 5 5 NUM fnp-5195 54 127 department department NOUN fnp-5195 54 128 of of ADP fnp-5195 54 129 ophthalmology ophthalmology NOUN fnp-5195 54 130 and and CCONJ fnp-5195 54 131 visual visual ADJ fnp-5195 54 132 sciences sciences PROPN fnp-5195 54 133 , , PUNCT fnp-5195 54 134 university university NOUN fnp-5195 54 135 of of ADP fnp-5195 54 136 british british PROPN fnp-5195 54 137 columbia columbia PROPN fnp-5195 54 138 , , PUNCT fnp-5195 54 139 vancouver vancouver PROPN fnp-5195 54 140 , , PUNCT fnp-5195 54 141 bc bc PROPN fnp-5195 54 142 , , PUNCT fnp-5195 54 143 canada canada PROPN fnp-5195 54 144 6 6 NUM fnp-5195 54 145 institute institute PROPN fnp-5195 54 146 of of ADP fnp-5195 54 147 biomedical biomedical ADJ fnp-5195 54 148 engineering engineering NOUN fnp-5195 54 149 , , PUNCT fnp-5195 54 150 science science NOUN fnp-5195 54 151 and and CCONJ fnp-5195 54 152 technology technology NOUN fnp-5195 54 153 ( ( PUNCT fnp-5195 54 154 ibest ib ADJ fnp-5195 54 155 ) ) PUNCT fnp-5195 54 156 , , PUNCT fnp-5195 54 157 st st PROPN fnp-5195 54 158 . . PROPN fnp-5195 54 159 michael michael PROPN fnp-5195 54 160 's 's PART fnp-5195 54 161 hospital hospital NOUN fnp-5195 54 162 , , PUNCT fnp-5195 54 163 toronto toronto PROPN fnp-5195 54 164 metropolitan metropolitan PROPN fnp-5195 54 165 university university PROPN fnp-5195 54 166 , , PUNCT fnp-5195 54 167 toronto toronto PROPN fnp-5195 54 168 , , PUNCT fnp-5195 54 169 on on ADP fnp-5195 54 170 , , PUNCT fnp-5195 54 171 canada canada PROPN fnp-5195 54 172 imaging image VERB fnp-5195 54 173 biomarkers biomarker NOUN fnp-5195 54 174 of of ADP fnp-5195 54 175 axonal axonal ADJ fnp-5195 54 176 pathology pathology NOUN fnp-5195 54 177 in in ADP fnp-5195 54 178 amyotrophic amyotrophic ADJ fnp-5195 54 179 lateral lateral ADJ fnp-5195 54 180 sclerosis sclerosis NOUN fnp-5195 54 181 ( ( PUNCT fnp-5195 54 182 als als NOUN fnp-5195 54 183 ) ) PUNCT fnp-5195 54 184 remain remain VERB fnp-5195 54 185 limited limited ADJ fnp-5195 54 186 . . PUNCT fnp-5195 55 1 we we PRON fnp-5195 55 2 identified identify VERB fnp-5195 55 3 axonal axonal ADJ fnp-5195 55 4 spheroids spheroid NOUN fnp-5195 55 5 , , PUNCT fnp-5195 55 6 a a DET fnp-5195 55 7 pathological pathological ADJ fnp-5195 55 8 hallmark hallmark NOUN fnp-5195 55 9 of of ADP fnp-5195 55 10 als al NOUN fnp-5195 55 11 , , PUNCT fnp-5195 55 12 in in ADP fnp-5195 55 13 the the DET fnp-5195 55 14 post post ADJ fnp-5195 55 15 - - ADJ fnp-5195 55 16 mortem mortem ADJ fnp-5195 55 17 retina retina NOUN fnp-5195 55 18 of of ADP fnp-5195 55 19 als als NOUN fnp-5195 55 20 patients patient NOUN fnp-5195 55 21 . . PUNCT fnp-5195 56 1 we we PRON fnp-5195 56 2 aim aim VERB fnp-5195 56 3 to to PART fnp-5195 56 4 establish establish VERB fnp-5195 56 5 the the DET fnp-5195 56 6 imaging imaging NOUN fnp-5195 56 7 of of ADP fnp-5195 56 8 axonal axonal ADJ fnp-5195 56 9 pathology pathology NOUN fnp-5195 56 10 in in ADP fnp-5195 56 11 the the DET fnp-5195 56 12 retina retina NOUN fnp-5195 56 13 as as ADP fnp-5195 56 14 a a DET fnp-5195 56 15 non non ADJ fnp-5195 56 16 - - ADJ fnp-5195 56 17 invasive invasive ADJ fnp-5195 56 18 als als NOUN fnp-5195 56 19 biomarker biomarker NOUN fnp-5195 56 20 . . PUNCT fnp-5195 57 1 following follow VERB fnp-5195 57 2 ethics ethic NOUN fnp-5195 57 3 approval approval NOUN fnp-5195 57 4 , , PUNCT fnp-5195 57 5 10 10 NUM fnp-5195 57 6 post post ADJ fnp-5195 57 7 - - ADJ fnp-5195 57 8 mortem mortem ADJ fnp-5195 57 9 als als NOUN fnp-5195 57 10 and and CCONJ fnp-5195 57 11 8 8 NUM fnp-5195 57 12 age age NOUN fnp-5195 57 13 - - PUNCT fnp-5195 57 14 matched match VERB fnp-5195 57 15 control control NOUN fnp-5195 57 16 eyes eye NOUN fnp-5195 57 17 were be AUX fnp-5195 57 18 imaged image VERB fnp-5195 57 19 using use VERB fnp-5195 57 20 a a DET fnp-5195 57 21 clinical clinical ADJ fnp-5195 57 22 eye eye NOUN fnp-5195 57 23 imaging imaging NOUN fnp-5195 57 24 device device NOUN fnp-5195 57 25 ( ( PUNCT fnp-5195 57 26 spectralis spectralis PROPN fnp-5195 57 27 , , PUNCT fnp-5195 57 28 heidelberg heidelberg NOUN fnp-5195 57 29 engineering engineering NOUN fnp-5195 57 30 ) ) PUNCT fnp-5195 57 31 combining combine VERB fnp-5195 57 32 confocal confocal ADJ fnp-5195 57 33 scanning scanning NOUN fnp-5195 57 34 laser laser NOUN fnp-5195 57 35 ophthalmoscope ophthalmoscope NOUN fnp-5195 57 36 and and CCONJ fnp-5195 57 37 optical optical ADJ fnp-5195 57 38 coherence coherence NOUN fnp-5195 57 39 tomography tomography NOUN fnp-5195 57 40 ( ( PUNCT fnp-5195 57 41 oct oct PROPN fnp-5195 57 42 ) ) PUNCT fnp-5195 57 43 . . PUNCT fnp-5195 58 1 confocal confocal ADJ fnp-5195 58 2 microscopy microscopy NOUN fnp-5195 58 3 imaging imaging NOUN fnp-5195 58 4 of of ADP fnp-5195 58 5 phosphorylated phosphorylate VERB fnp-5195 58 6 neurofilament neurofilament NOUN fnp-5195 58 7 ( ( PUNCT fnp-5195 58 8 p p NOUN fnp-5195 58 9 - - PUNCT fnp-5195 58 10 nf nf NOUN fnp-5195 58 11 ) ) PUNCT fnp-5195 58 12 immunostained immunostaine VERB fnp-5195 58 13 retinas retina NOUN fnp-5195 58 14 was be AUX fnp-5195 58 15 performed perform VERB fnp-5195 58 16 for for ADP fnp-5195 58 17 histological histological ADJ fnp-5195 58 18 validation validation NOUN fnp-5195 58 19 . . PUNCT fnp-5195 59 1 sequential sequential ADJ fnp-5195 59 2 in in ADP fnp-5195 59 3 vivo vivo ADJ fnp-5195 59 4 retinal retinal ADJ fnp-5195 59 5 imaging imaging NOUN fnp-5195 59 6 was be AUX fnp-5195 59 7 performed perform VERB fnp-5195 59 8 in in ADP fnp-5195 59 9 als als NOUN fnp-5195 59 10 mice mouse NOUN fnp-5195 59 11 ( ( PUNCT fnp-5195 59 12 n=28 n=28 ADV fnp-5195 59 13 ) ) PUNCT fnp-5195 59 14 and and CCONJ fnp-5195 59 15 age age NOUN fnp-5195 59 16 - - PUNCT fnp-5195 59 17 matched match VERB fnp-5195 59 18 controls control NOUN fnp-5195 59 19 ( ( PUNCT fnp-5195 59 20 n=28 n=28 ADV fnp-5195 59 21 ) ) PUNCT fnp-5195 59 22 with with ADP fnp-5195 59 23 spectralis spectralis PROPN fnp-5195 59 24 . . PUNCT fnp-5195 60 1 statistical statistical ADJ fnp-5195 60 2 analysis analysis NOUN fnp-5195 60 3 was be AUX fnp-5195 60 4 performed perform VERB fnp-5195 60 5 using use VERB fnp-5195 60 6 generalized generalize VERB fnp-5195 60 7 linear linear ADJ fnp-5195 60 8 mixed mixed ADJ fnp-5195 60 9 modeling modeling NOUN fnp-5195 60 10 ( ( PUNCT fnp-5195 60 11 rstudio rstudio NOUN fnp-5195 60 12 ) ) PUNCT fnp-5195 60 13 . . PUNCT fnp-5195 61 1 ex ex PRON fnp-5195 61 2 vivo vivo ADJ fnp-5195 61 3 human human ADJ fnp-5195 61 4 retinal retinal ADJ fnp-5195 61 5 fundus fundus NOUN fnp-5195 61 6 imaging imaging NOUN fnp-5195 61 7 ( ( PUNCT fnp-5195 61 8 blue blue ADJ fnp-5195 61 9 reflectance reflectance NOUN fnp-5195 61 10 ) ) PUNCT fnp-5195 61 11 detected detect VERB fnp-5195 61 12 more more ADV fnp-5195 61 13 hyperreflective hyperreflective ADJ fnp-5195 61 14 puncta puncta NOUN fnp-5195 61 15 in in ADP fnp-5195 61 16 als als NOUN fnp-5195 61 17 patients patient NOUN fnp-5195 61 18 compared compare VERB fnp-5195 61 19 to to ADP fnp-5195 61 20 controls control NOUN fnp-5195 61 21 ( ( PUNCT fnp-5195 61 22 19.04±22.5 19.04±22.5 NUM fnp-5195 61 23 vs. vs. ADP fnp-5195 61 24 2.7±1.6 2.7±1.6 NUM fnp-5195 61 25 /mm2 /mm2 NOUN fnp-5195 61 26 , , PUNCT fnp-5195 61 27 p<0.05 p<0.05 PROPN fnp-5195 61 28 ) ) PUNCT fnp-5195 61 29 . . PUNCT fnp-5195 62 1 oct oct PROPN fnp-5195 62 2 confirmed confirm VERB fnp-5195 62 3 puncta puncta PROPN fnp-5195 62 4 were be AUX fnp-5195 62 5 localized localize VERB fnp-5195 62 6 in in ADP fnp-5195 62 7 the the DET fnp-5195 62 8 retinal retinal ADJ fnp-5195 62 9 nerve nerve NOUN fnp-5195 62 10 fiber fiber NOUN fnp-5195 62 11 layer layer NOUN fnp-5195 62 12 ( ( PUNCT fnp-5195 62 13 rnfl rnfl NOUN fnp-5195 62 14 ) ) PUNCT fnp-5195 62 15 . . PUNCT fnp-5195 63 1 in in ADP fnp-5195 63 2 vivo vivo NOUN fnp-5195 63 3 mouse mouse NOUN fnp-5195 63 4 fundus fundus NOUN fnp-5195 63 5 imaging imaging NOUN fnp-5195 63 6 ( ( PUNCT fnp-5195 63 7 infrared infrared ADJ fnp-5195 63 8 reflectance reflectance NOUN fnp-5195 63 9 ) ) PUNCT fnp-5195 63 10 showed show VERB fnp-5195 63 11 significantly significantly ADV fnp-5195 63 12 more more ADV fnp-5195 63 13 puncta puncta ADJ fnp-5195 63 14 in in ADP fnp-5195 63 15 the the DET fnp-5195 63 16 retina retina NOUN fnp-5195 63 17 of of ADP fnp-5195 63 18 als als NOUN fnp-5195 63 19 mice mouse NOUN fnp-5195 63 20 , , PUNCT fnp-5195 63 21 compared compare VERB fnp-5195 63 22 to to ADP fnp-5195 63 23 controls control NOUN fnp-5195 63 24 ( ( PUNCT fnp-5195 63 25 7.2±5.2 7.2±5.2 NUM fnp-5195 63 26 vs. vs. ADP fnp-5195 63 27 1.8±0.9 1.8±0.9 NUM fnp-5195 63 28 , , PUNCT fnp-5195 63 29 p<0.05 p<0.05 NOUN fnp-5195 63 30 ) ) PUNCT fnp-5195 63 31 , , PUNCT fnp-5195 63 32 with with ADP fnp-5195 63 33 a a DET fnp-5195 63 34 progressive progressive ADJ fnp-5195 63 35 increase increase NOUN fnp-5195 63 36 over over ADP fnp-5195 63 37 time time NOUN fnp-5195 63 38 in in ADP fnp-5195 63 39 als als NOUN fnp-5195 63 40 mice mouse NOUN fnp-5195 63 41 ( ( PUNCT fnp-5195 63 42 p<0.001 p<0.001 PROPN fnp-5195 63 43 ) ) PUNCT fnp-5195 63 44 . . PUNCT fnp-5195 64 1 immunofluorescence immunofluorescence NOUN fnp-5195 64 2 studies study NOUN fnp-5195 64 3 showed show VERB fnp-5195 64 4 the the DET fnp-5195 64 5 presence presence NOUN fnp-5195 64 6 of of ADP fnp-5195 64 7 p p NOUN fnp-5195 64 8 - - PUNCT fnp-5195 64 9 nf nf ADJ fnp-5195 64 10 - - PUNCT fnp-5195 64 11 positive positive ADJ fnp-5195 64 12 axonal axonal ADJ fnp-5195 64 13 spheroids spheroid NOUN fnp-5195 64 14 in in ADP fnp-5195 64 15 the the DET fnp-5195 64 16 rnfl rnfl NOUN fnp-5195 64 17 in in ADP fnp-5195 64 18 human human ADJ fnp-5195 64 19 and and CCONJ fnp-5195 64 20 mouse mouse NOUN fnp-5195 64 21 als als NOUN fnp-5195 64 22 retinas retina NOUN fnp-5195 64 23 . . PUNCT fnp-5195 65 1 axonal axonal ADJ fnp-5195 65 2 pathology pathology NOUN fnp-5195 65 3 in in ADP fnp-5195 65 4 als als NOUN fnp-5195 65 5 is be AUX fnp-5195 65 6 detectable detectable ADJ fnp-5195 65 7 with with ADP fnp-5195 65 8 a a DET fnp-5195 65 9 widely widely ADV fnp-5195 65 10 available available ADJ fnp-5195 65 11 clinical clinical ADJ fnp-5195 65 12 eye eye NOUN fnp-5195 65 13 imaging imaging NOUN fnp-5195 65 14 device device NOUN fnp-5195 65 15 . . PUNCT fnp-5195 66 1 this this DET fnp-5195 66 2 study study NOUN fnp-5195 66 3 suggests suggest VERB fnp-5195 66 4 imaging imaging NOUN fnp-5195 66 5 of of ADP fnp-5195 66 6 the the DET fnp-5195 66 7 axonal axonal ADJ fnp-5195 66 8 pathology pathology NOUN fnp-5195 66 9 in in ADP fnp-5195 66 10 the the DET fnp-5195 66 11 eye eye NOUN fnp-5195 66 12 is be AUX fnp-5195 66 13 a a DET fnp-5195 66 14 promising promising ADJ fnp-5195 66 15 biomarker biomarker NOUN fnp-5195 66 16 for for ADP fnp-5195 66 17 assessing assess VERB fnp-5195 66 18 ocular ocular ADJ fnp-5195 66 19 phenotype phenotype NOUN fnp-5195 66 20 , , PUNCT fnp-5195 66 21 progression progression NOUN fnp-5195 66 22 , , PUNCT fnp-5195 66 23 and and CCONJ fnp-5195 66 24 treatment treatment NOUN fnp-5195 66 25 response response NOUN fnp-5195 66 26 in in ADP fnp-5195 66 27 clinical clinical ADJ fnp-5195 66 28 trials trial NOUN fnp-5195 66 29 in in ADP fnp-5195 66 30 als al NOUN fnp-5195 66 31 . . PUNCT fnp-5195 66 32     SPACE fnp-5195 67 1 abstract abstract ADJ fnp-5195 67 2 6 6 NUM fnp-5195 67 3 free free ADJ fnp-5195 67 4 neuropathol neuropathol NOUN fnp-5195 67 5 4:20:9 4:20:9 NUM fnp-5195 67 6 progressive progressive ADJ fnp-5195 67 7 supranuclear supranuclear ADJ fnp-5195 67 8 palsy palsy ADJ fnp-5195 67 9 : : PUNCT fnp-5195 67 10 a a DET fnp-5195 67 11 novel novel ADJ fnp-5195 67 12 phenotype phenotype NOUN fnp-5195 67 13 of of ADP fnp-5195 67 14 germline germline PROPN fnp-5195 67 15 sqstm1 sqstm1 PROPN fnp-5195 67 16 ( ( PUNCT fnp-5195 67 17 p62 p62 NOUN fnp-5195 67 18 ) ) PUNCT fnp-5195 67 19 mutation mutation NOUN fnp-5195 67 20 madison madison PROPN fnp-5195 67 21 t. t. PROPN fnp-5195 67 22 gray1 gray1 PROPN fnp-5195 67 23 , , PUNCT fnp-5195 67 24 elizabeth elizabeth PROPN fnp-5195 67 25 finger2 finger2 PROPN fnp-5195 67 26 , , PUNCT fnp-5195 67 27 lee lee PROPN fnp-5195 67 28 cyn cyn PROPN fnp-5195 67 29 ang1,2 ang1,2 PROPN fnp-5195 67 30 1 1 NUM fnp-5195 67 31 department department NOUN fnp-5195 67 32 of of ADP fnp-5195 67 33 pathology pathology NOUN fnp-5195 67 34 and and CCONJ fnp-5195 67 35 laboratory laboratory NOUN fnp-5195 67 36 medicine medicine NOUN fnp-5195 67 37 , , PUNCT fnp-5195 67 38 schulich schulich NOUN fnp-5195 67 39 school school NOUN fnp-5195 67 40 of of ADP fnp-5195 67 41 medicine medicine NOUN fnp-5195 67 42 , , PUNCT fnp-5195 67 43 western western ADJ fnp-5195 67 44 university university NOUN fnp-5195 67 45 , , PUNCT fnp-5195 67 46 london london PROPN fnp-5195 67 47 , , PUNCT fnp-5195 67 48 on on ADP fnp-5195 67 49 , , PUNCT fnp-5195 67 50 canada canada PROPN fnp-5195 67 51 2 2 NUM fnp-5195 67 52 department department NOUN fnp-5195 67 53 of of ADP fnp-5195 67 54 clinical clinical ADJ fnp-5195 67 55 neurological neurological ADJ fnp-5195 67 56 sciences science NOUN fnp-5195 67 57 , , PUNCT fnp-5195 67 58 schulich schulich NOUN fnp-5195 67 59 school school NOUN fnp-5195 67 60 of of ADP fnp-5195 67 61 medicine medicine NOUN fnp-5195 67 62 , , PUNCT fnp-5195 67 63 western western ADJ fnp-5195 67 64 university university NOUN fnp-5195 67 65 , , PUNCT fnp-5195 67 66 london london PROPN fnp-5195 67 67 , , PUNCT fnp-5195 67 68 on on ADP fnp-5195 67 69 , , PUNCT fnp-5195 67 70 canada canada PROPN fnp-5195 67 71 a a DET fnp-5195 67 72 woman woman NOUN fnp-5195 67 73 presented present VERB fnp-5195 67 74 at at ADP fnp-5195 67 75 age age NOUN fnp-5195 67 76 61 61 NUM fnp-5195 67 77 with with ADP fnp-5195 67 78 anhedonia anhedonia NOUN fnp-5195 67 79 and and CCONJ fnp-5195 67 80 emotional emotional ADJ fnp-5195 67 81 lability lability NOUN fnp-5195 67 82 with with ADP fnp-5195 67 83 an an DET fnp-5195 67 84 mmse mmse NOUN fnp-5195 67 85 of of ADP fnp-5195 67 86 28/30 28/30 NUM fnp-5195 67 87 . . PUNCT fnp-5195 68 1 two two NUM fnp-5195 68 2 years year NOUN fnp-5195 68 3 after after ADP fnp-5195 68 4 presentation presentation NOUN fnp-5195 68 5 , , PUNCT fnp-5195 68 6 she she PRON fnp-5195 68 7 developed develop VERB fnp-5195 68 8 disinhibition disinhibition NOUN fnp-5195 68 9 ― ― INTJ fnp-5195 68 10 notably notably ADV fnp-5195 68 11 inappropriate inappropriate ADJ fnp-5195 68 12 giggling giggle VERB fnp-5195 68 13 ― ― NOUN fnp-5195 68 14 as as ADV fnp-5195 68 15 well well ADV fnp-5195 68 16 as as ADP fnp-5195 68 17 a a DET fnp-5195 68 18 wide wide ADV fnp-5195 68 19 - - PUNCT fnp-5195 68 20 based base VERB fnp-5195 68 21 gait gait NOUN fnp-5195 68 22 . . PUNCT fnp-5195 69 1 five five NUM fnp-5195 69 2 years year NOUN fnp-5195 69 3 after after ADP fnp-5195 69 4 initial initial ADJ fnp-5195 69 5 presentation presentation NOUN fnp-5195 69 6 , , PUNCT fnp-5195 69 7 there there PRON fnp-5195 69 8 was be VERB fnp-5195 69 9 the the DET fnp-5195 69 10 development development NOUN fnp-5195 69 11 of of ADP fnp-5195 69 12 ocular ocular ADJ fnp-5195 69 13 abnormalities abnormality NOUN fnp-5195 69 14 including include VERB fnp-5195 69 15 saccadic saccadic ADJ fnp-5195 69 16 intrusions intrusion NOUN fnp-5195 69 17 and and CCONJ fnp-5195 69 18 upgaze upgaze ADJ fnp-5195 69 19 limitation limitation NOUN fnp-5195 69 20 . . PUNCT fnp-5195 70 1 fine fine ADJ fnp-5195 70 2 motor motor NOUN fnp-5195 70 3 movements movement NOUN fnp-5195 70 4 were be AUX fnp-5195 70 5 slower slow ADJ fnp-5195 70 6 and and CCONJ fnp-5195 70 7 less less ADV fnp-5195 70 8 elegant elegant ADJ fnp-5195 70 9 on on ADP fnp-5195 70 10 the the DET fnp-5195 70 11 left left NOUN fnp-5195 70 12 . . PUNCT fnp-5195 71 1 the the DET fnp-5195 71 2 patient patient NOUN fnp-5195 71 3 passed pass VERB fnp-5195 71 4 away away ADV fnp-5195 71 5 in in ADP fnp-5195 71 6 a a DET fnp-5195 71 7 nursing nursing NOUN fnp-5195 71 8 home home NOUN fnp-5195 71 9 seven seven NUM fnp-5195 71 10 years year NOUN fnp-5195 71 11 after after ADP fnp-5195 71 12 presentation presentation NOUN fnp-5195 71 13 . . PUNCT fnp-5195 72 1 family family NOUN fnp-5195 72 2 history history NOUN fnp-5195 72 3 was be AUX fnp-5195 72 4 notable notable ADJ fnp-5195 72 5 for for SCONJ fnp-5195 72 6 a a DET fnp-5195 72 7 father father NOUN fnp-5195 72 8 and and CCONJ fnp-5195 72 9 paternal paternal ADJ fnp-5195 72 10 grandmother grandmother NOUN fnp-5195 72 11 who who PRON fnp-5195 72 12 were be AUX fnp-5195 72 13 prone prone ADJ fnp-5195 72 14 to to PART fnp-5195 72 15 giggle giggle VERB fnp-5195 72 16 and and CCONJ fnp-5195 72 17 have have VERB fnp-5195 72 18 angry angry ADJ fnp-5195 72 19 outbursts outburst NOUN fnp-5195 72 20 . . PUNCT fnp-5195 73 1 neither neither CCONJ fnp-5195 73 2 carried carry VERB fnp-5195 73 3 a a DET fnp-5195 73 4 formal formal ADJ fnp-5195 73 5 neurological neurological ADJ fnp-5195 73 6 diagnosis diagnosis NOUN fnp-5195 73 7 . . PUNCT fnp-5195 74 1 antemortem antemortem PROPN fnp-5195 74 2 genetic genetic ADJ fnp-5195 74 3 testing testing NOUN fnp-5195 74 4 in in ADP fnp-5195 74 5 our our PRON fnp-5195 74 6 patient patient NOUN fnp-5195 74 7 revealed reveal VERB fnp-5195 74 8 a a DET fnp-5195 74 9 c.1211t c.1211t PROPN fnp-5195 74 10 > > X fnp-5195 74 11 c(p c(p NOUN fnp-5195 74 12 . . PUNCT fnp-5195 74 13 met404thr met404thr NOUN fnp-5195 74 14 ) ) PUNCT fnp-5195 74 15 mutation mutation NOUN fnp-5195 74 16 in in ADP fnp-5195 74 17 sqstm1(p62 sqstm1(p62 NOUN fnp-5195 74 18 ) ) PUNCT fnp-5195 74 19 . . PUNCT fnp-5195 75 1 at at ADP fnp-5195 75 2 autopsy autopsy ADJ fnp-5195 75 3 , , PUNCT fnp-5195 75 4 there there PRON fnp-5195 75 5 was be VERB fnp-5195 75 6 moderate moderate ADJ fnp-5195 75 7 frontotemporal frontotemporal ADJ fnp-5195 75 8 atrophy atrophy NOUN fnp-5195 75 9 . . PUNCT fnp-5195 76 1 histological histological ADJ fnp-5195 76 2 sections section NOUN fnp-5195 76 3 showed show VERB fnp-5195 76 4 atrophy atrophy NOUN fnp-5195 76 5 and and CCONJ fnp-5195 76 6 gliosis gliosis NOUN fnp-5195 76 7 of of ADP fnp-5195 76 8 the the DET fnp-5195 76 9 subthalamic subthalamic ADJ fnp-5195 76 10 nucleus nucleus NOUN fnp-5195 76 11 . . PUNCT fnp-5195 77 1 grumose grumose ADJ fnp-5195 77 2 degeneration degeneration NOUN fnp-5195 77 3 of of ADP fnp-5195 77 4 the the DET fnp-5195 77 5 dentate dentate ADJ fnp-5195 77 6 nucleus nucleus NOUN fnp-5195 77 7 was be AUX fnp-5195 77 8 also also ADV fnp-5195 77 9 present present ADJ fnp-5195 77 10 . . PUNCT fnp-5195 78 1 p62 p62 NOUN fnp-5195 78 2 and and CCONJ fnp-5195 78 3 phosphorylated phosphorylate VERB fnp-5195 78 4 - - PUNCT fnp-5195 78 5 tau(at8 tau(at8 NOUN fnp-5195 78 6 ) ) PUNCT fnp-5195 78 7 immunostaining immunostaining NOUN fnp-5195 78 8 demonstrated demonstrate VERB fnp-5195 78 9 globose globose NOUN fnp-5195 78 10 tangles tangle NOUN fnp-5195 78 11 most most ADV fnp-5195 78 12 prominent prominent ADJ fnp-5195 78 13 in in ADP fnp-5195 78 14 substantia substantia NOUN fnp-5195 78 15 nigra nigra PROPN fnp-5195 78 16 , , PUNCT fnp-5195 78 17 pontine pontine ADJ fnp-5195 78 18 nuclei nucleus NOUN fnp-5195 78 19 , , PUNCT fnp-5195 78 20 and and CCONJ fnp-5195 78 21 inferior inferior ADJ fnp-5195 78 22 olive olive NOUN fnp-5195 78 23 . . PUNCT fnp-5195 79 1 neurofibrillary neurofibrillary ADJ fnp-5195 79 2 tangles tangle NOUN fnp-5195 79 3 were be AUX fnp-5195 79 4 rare rare ADJ fnp-5195 79 5 in in ADP fnp-5195 79 6 cortex cortex NOUN fnp-5195 79 7 and and CCONJ fnp-5195 79 8 basal basal ADJ fnp-5195 79 9 ganglia ganglia NOUN fnp-5195 79 10 where where SCONJ fnp-5195 79 11 tufted tufte VERB fnp-5195 79 12 astrocytes astrocyte NOUN fnp-5195 79 13 and and CCONJ fnp-5195 79 14 coiled coil VERB fnp-5195 79 15 bodies body NOUN fnp-5195 79 16 predominated predominate VERB fnp-5195 79 17 . . PUNCT fnp-5195 80 1 no no DET fnp-5195 80 2 abnormal abnormal ADJ fnp-5195 80 3 beta beta NOUN fnp-5195 80 4 - - PUNCT fnp-5195 80 5 amyloid amyloid NOUN fnp-5195 80 6 , , PUNCT fnp-5195 80 7 tdp-43 tdp-43 PROPN fnp-5195 80 8 , , PUNCT fnp-5195 80 9 or or CCONJ fnp-5195 80 10 alpha alpha NOUN fnp-5195 80 11 - - PUNCT fnp-5195 80 12 synuclein synuclein NOUN fnp-5195 80 13 staining stain VERB fnp-5195 80 14 was be AUX fnp-5195 80 15 present present ADJ fnp-5195 80 16 . . PUNCT fnp-5195 81 1 this this PRON fnp-5195 81 2 was be AUX fnp-5195 81 3 consistent consistent ADJ fnp-5195 81 4 with with ADP fnp-5195 81 5 a a DET fnp-5195 81 6 pathological pathological ADJ fnp-5195 81 7 diagnosis diagnosis NOUN fnp-5195 81 8 of of ADP fnp-5195 81 9 progressive progressive ADJ fnp-5195 81 10 supranuclear supranuclear ADJ fnp-5195 81 11 palsy palsy ADJ fnp-5195 81 12 ( ( PUNCT fnp-5195 81 13 psp psp NOUN fnp-5195 81 14 ) ) PUNCT fnp-5195 81 15 . . PUNCT fnp-5195 82 1 mutations mutation NOUN fnp-5195 82 2 of of ADP fnp-5195 82 3 sqstm1(p62 sqstm1(p62 NOUN fnp-5195 82 4 ) ) PUNCT fnp-5195 82 5 have have AUX fnp-5195 82 6 been be AUX fnp-5195 82 7 associated associate VERB fnp-5195 82 8 with with ADP fnp-5195 82 9 ftld ftld ADJ fnp-5195 82 10 / / SYM fnp-5195 82 11 als al NOUN fnp-5195 82 12 , , PUNCT fnp-5195 82 13 and and CCONJ fnp-5195 82 14 inclusion inclusion NOUN fnp-5195 82 15 body body NOUN fnp-5195 82 16 myositis myositis NOUN fnp-5195 82 17 - - PUNCT fnp-5195 82 18 like like ADJ fnp-5195 82 19 myopathy myopathy ADJ fnp-5195 82 20 , , PUNCT fnp-5195 82 21 and and CCONJ fnp-5195 82 22 familial familial ADJ fnp-5195 82 23 paget paget NOUN fnp-5195 82 24 disease disease NOUN fnp-5195 82 25 of of ADP fnp-5195 82 26 bone bone NOUN fnp-5195 82 27 . . PUNCT fnp-5195 83 1 here here ADV fnp-5195 83 2 , , PUNCT fnp-5195 83 3 we we PRON fnp-5195 83 4 report report VERB fnp-5195 83 5 ( ( PUNCT fnp-5195 83 6 to to ADP fnp-5195 83 7 our our PRON fnp-5195 83 8 knowledge knowledge NOUN fnp-5195 83 9 ) ) PUNCT fnp-5195 83 10 the the DET fnp-5195 83 11 first first ADJ fnp-5195 83 12 case case NOUN fnp-5195 83 13 of of ADP fnp-5195 83 14 sqstm1 sqstm1 NOUN fnp-5195 83 15 mutation mutation NOUN fnp-5195 83 16 presenting present VERB fnp-5195 83 17 with with ADP fnp-5195 83 18 pathologically pathologically ADV fnp-5195 83 19 - - PUNCT fnp-5195 83 20 confirmed confirm VERB fnp-5195 83 21 psp psp NOUN fnp-5195 83 22 . . PUNCT fnp-5195 84 1 the the DET fnp-5195 84 2 mutation mutation NOUN fnp-5195 84 3 in in ADP fnp-5195 84 4 this this DET fnp-5195 84 5 case case NOUN fnp-5195 84 6 ( ( PUNCT fnp-5195 84 7 p.met404thr p.met404thr NOUN fnp-5195 84 8 ) ) PUNCT fnp-5195 84 9 has have AUX fnp-5195 84 10 been be AUX fnp-5195 84 11 reported report VERB fnp-5195 84 12 to to PART fnp-5195 84 13 impair impair VERB fnp-5195 84 14 ubiquitin ubiquitin ADJ fnp-5195 84 15 binding binding NOUN fnp-5195 84 16 and and CCONJ fnp-5195 84 17 has have AUX fnp-5195 84 18 not not PART fnp-5195 84 19 previously previously ADV fnp-5195 84 20 been be AUX fnp-5195 84 21 associated associate VERB fnp-5195 84 22 with with ADP fnp-5195 84 23 neurodegenerative neurodegenerative ADJ fnp-5195 84 24 disease disease NOUN fnp-5195 84 25 . . PUNCT fnp-5195 84 26     SPACE fnp-5195 85 1 abstract abstract ADJ fnp-5195 85 2 7 7 NUM fnp-5195 85 3 free free ADJ fnp-5195 85 4 neuropathol neuropathol NOUN fnp-5195 85 5 4:20:10 4:20:10 PRON fnp-5195 85 6 a a DET fnp-5195 85 7 108 108 NUM fnp-5195 85 8 year year NOUN fnp-5195 85 9 old old ADJ fnp-5195 85 10 brain brain NOUN fnp-5195 85 11 with with ADP fnp-5195 85 12 near near ADJ fnp-5195 85 13 normal normal ADJ fnp-5195 85 14 cognition cognition NOUN fnp-5195 85 15 david david PROPN fnp-5195 85 16 g. g. PROPN fnp-5195 85 17 munoz1,2,4 munoz1,2,4 PROPN fnp-5195 85 18 , , PUNCT fnp-5195 85 19 julia julia PROPN fnp-5195 85 20 keith3,4 keith3,4 PROPN fnp-5195 85 21 1 1 NUM fnp-5195 85 22 division division NOUN fnp-5195 85 23 of of ADP fnp-5195 85 24 pathology pathology NOUN fnp-5195 85 25 , , PUNCT fnp-5195 85 26 unity unity NOUN fnp-5195 85 27 health health NOUN fnp-5195 85 28 , , PUNCT fnp-5195 85 29 toronto toronto PROPN fnp-5195 85 30 , , PUNCT fnp-5195 85 31 on on ADV fnp-5195 85 32 , , PUNCT fnp-5195 85 33 canada canada PROPN fnp-5195 85 34 2 2 NUM fnp-5195 85 35 keenan keenan PROPN fnp-5195 85 36 research research NOUN fnp-5195 85 37 centre centre PROPN fnp-5195 85 38 for for ADP fnp-5195 85 39 biomedical biomedical ADJ fnp-5195 85 40 research research NOUN fnp-5195 85 41 , , PUNCT fnp-5195 85 42 the the DET fnp-5195 85 43 li li PROPN fnp-5195 85 44 ka ka PROPN fnp-5195 85 45 shing shing PROPN fnp-5195 85 46 knowledge knowledge PROPN fnp-5195 85 47 institute institute PROPN fnp-5195 85 48 , , PUNCT fnp-5195 85 49 st st PROPN fnp-5195 85 50 . . PROPN fnp-5195 85 51 michael michael PROPN fnp-5195 85 52 ’s ’s PART fnp-5195 85 53 hospital hospital PROPN fnp-5195 85 54 , , PUNCT fnp-5195 85 55 toronto toronto PROPN fnp-5195 85 56 , , PUNCT fnp-5195 85 57 on on ADP fnp-5195 85 58 , , PUNCT fnp-5195 85 59 canada canada PROPN fnp-5195 85 60 3 3 NUM fnp-5195 85 61 division division NOUN fnp-5195 85 62 of of ADP fnp-5195 85 63 pathology pathology PROPN fnp-5195 85 64 , , PUNCT fnp-5195 85 65 sunnybrook sunnybrook PROPN fnp-5195 85 66 health health PROPN fnp-5195 85 67 sciences sciences PROPN fnp-5195 85 68 centre centre PROPN fnp-5195 85 69 , , PUNCT fnp-5195 85 70 toronto toronto PROPN fnp-5195 85 71 , , PUNCT fnp-5195 85 72 on on ADP fnp-5195 85 73 , , PUNCT fnp-5195 85 74 canada canada PROPN fnp-5195 85 75 4 4 NUM fnp-5195 85 76 department department PROPN fnp-5195 85 77 of of ADP fnp-5195 85 78 laboratory laboratory NOUN fnp-5195 85 79 medicine medicine NOUN fnp-5195 85 80 and and CCONJ fnp-5195 85 81 pathobiology pathobiology NOUN fnp-5195 85 82 , , PUNCT fnp-5195 85 83 university university PROPN fnp-5195 85 84 of of ADP fnp-5195 85 85 toronto toronto PROPN fnp-5195 85 86 , , PUNCT fnp-5195 85 87 on on ADP fnp-5195 85 88 , , PUNCT fnp-5195 85 89 canada canada PROPN fnp-5195 85 90 a a DET fnp-5195 85 91 108 108 NUM fnp-5195 85 92 year year NOUN fnp-5195 85 93 old old ADJ fnp-5195 85 94 male male ADJ fnp-5195 85 95 veteran veteran NOUN fnp-5195 85 96 lived live VERB fnp-5195 85 97 in in ADP fnp-5195 85 98 a a DET fnp-5195 85 99 nursing nursing NOUN fnp-5195 85 100 home home NOUN fnp-5195 85 101 , , PUNCT fnp-5195 85 102 and and CCONJ fnp-5195 85 103 participated participate VERB fnp-5195 85 104 in in ADP fnp-5195 85 105 regular regular ADJ fnp-5195 85 106 cognitive cognitive ADJ fnp-5195 85 107 testing testing NOUN fnp-5195 85 108 . . PUNCT fnp-5195 86 1 despite despite SCONJ fnp-5195 86 2 being be AUX fnp-5195 86 3 legally legally ADV fnp-5195 86 4 blind blind ADJ fnp-5195 86 5 and and CCONJ fnp-5195 86 6 hearing hear VERB fnp-5195 86 7 impaired impair VERB fnp-5195 86 8 , , PUNCT fnp-5195 86 9 his his PRON fnp-5195 86 10 last last ADJ fnp-5195 86 11 mmse mmse ADJ fnp-5195 86 12 , , PUNCT fnp-5195 86 13 3 3 NUM fnp-5195 86 14 years year NOUN fnp-5195 86 15 prior prior ADV fnp-5195 86 16 to to ADP fnp-5195 86 17 death death NOUN fnp-5195 86 18 at at ADP fnp-5195 86 19 age age NOUN fnp-5195 86 20 105 105 NUM fnp-5195 86 21 was be AUX fnp-5195 86 22 25/30 25/30 NUM fnp-5195 86 23 . . PUNCT fnp-5195 87 1 the the DET fnp-5195 87 2 brain brain NOUN fnp-5195 87 3 weighed weigh VERB fnp-5195 87 4 1365 1365 NUM fnp-5195 87 5 gr gr NOUN fnp-5195 87 6 and and CCONJ fnp-5195 87 7 showed show VERB fnp-5195 87 8 severe severe ADJ fnp-5195 87 9 bilateral bilateral ADJ fnp-5195 87 10 hippocampal hippocampal ADJ fnp-5195 87 11 atrophy atrophy NOUN fnp-5195 87 12 . . PUNCT fnp-5195 88 1 h&e h&e PROPN fnp-5195 88 2 sections section NOUN fnp-5195 88 3 showed show VERB fnp-5195 88 4 complete complete ADJ fnp-5195 88 5 neuronal neuronal ADJ fnp-5195 88 6 loss loss NOUN fnp-5195 88 7 of of ADP fnp-5195 88 8 ca1 ca1 NOUN fnp-5195 88 9 bilaterally bilaterally ADV fnp-5195 88 10 , , PUNCT fnp-5195 88 11 and and CCONJ fnp-5195 88 12 severe severe ADJ fnp-5195 88 13 loss loss NOUN fnp-5195 88 14 of of ADP fnp-5195 88 15 vermal vermal ADJ fnp-5195 88 16 purkinje purkinje PROPN fnp-5195 88 17 cell cell NOUN fnp-5195 88 18 , , PUNCT fnp-5195 88 19 but but CCONJ fnp-5195 88 20 the the DET fnp-5195 88 21 neuronal neuronal ADJ fnp-5195 88 22 populations population NOUN fnp-5195 88 23 of of ADP fnp-5195 88 24 the the DET fnp-5195 88 25 neocortex neocortex NOUN fnp-5195 88 26 and and CCONJ fnp-5195 88 27 entorhinal entorhinal ADJ fnp-5195 88 28 cortex cortex NOUN fnp-5195 88 29 were be AUX fnp-5195 88 30 mostly mostly ADV fnp-5195 88 31 preserved preserve VERB fnp-5195 88 32 . . PUNCT fnp-5195 89 1 reactive reactive ADJ fnp-5195 89 2 gliosis gliosis NOUN fnp-5195 89 3 was be AUX fnp-5195 89 4 prominent prominent ADJ fnp-5195 89 5 throughout throughout ADP fnp-5195 89 6 the the DET fnp-5195 89 7 cingulate cingulate NOUN fnp-5195 89 8 cortex cortex NOUN fnp-5195 89 9 , , PUNCT fnp-5195 89 10 mostly mostly ADV fnp-5195 89 11 restricted restrict VERB fnp-5195 89 12 to to ADP fnp-5195 89 13 grey grey ADJ fnp-5195 89 14 - - PUNCT fnp-5195 89 15 white white ADJ fnp-5195 89 16 junction junction NOUN fnp-5195 89 17 in in ADP fnp-5195 89 18 the the DET fnp-5195 89 19 frontal frontal ADJ fnp-5195 89 20 , , PUNCT fnp-5195 89 21 parietal parietal ADJ fnp-5195 89 22 and and CCONJ fnp-5195 89 23 temporal temporal ADJ fnp-5195 89 24 cortices cortex NOUN fnp-5195 89 25 , , PUNCT fnp-5195 89 26 and and CCONJ fnp-5195 89 27 absent absent ADJ fnp-5195 89 28 in in ADP fnp-5195 89 29 the the DET fnp-5195 89 30 occipital occipital ADJ fnp-5195 89 31 cortex cortex NOUN fnp-5195 89 32 . . PUNCT fnp-5195 90 1 the the DET fnp-5195 90 2 main main ADJ fnp-5195 90 3 protein protein NOUN fnp-5195 90 4 deposit deposit NOUN fnp-5195 90 5 was be AUX fnp-5195 90 6 tdp-43 tdp-43 NOUN fnp-5195 90 7 , , PUNCT fnp-5195 90 8 present present ADJ fnp-5195 90 9 in in ADP fnp-5195 90 10 the the DET fnp-5195 90 11 frontotemporal frontotemporal ADJ fnp-5195 90 12 neocortex neocortex NOUN fnp-5195 90 13 as as ADP fnp-5195 90 14 neuronal neuronal ADJ fnp-5195 90 15 cytoplasmic cytoplasmic ADJ fnp-5195 90 16 inclusions inclusion NOUN fnp-5195 90 17 and and CCONJ fnp-5195 90 18 thick thick ADJ fnp-5195 90 19 short short ADJ fnp-5195 90 20 process process NOUN fnp-5195 90 21 in in ADP fnp-5195 90 22 the the DET fnp-5195 90 23 superficial superficial ADJ fnp-5195 90 24 layers layer NOUN fnp-5195 90 25 ( ( PUNCT fnp-5195 90 26 type type NOUN fnp-5195 90 27 a a NOUN fnp-5195 90 28 ) ) PUNCT fnp-5195 90 29 , , PUNCT fnp-5195 90 30 and and CCONJ fnp-5195 90 31 in in ADP fnp-5195 90 32 the the DET fnp-5195 90 33 hippocampus hippocampus NOUN fnp-5195 90 34 as as ADP fnp-5195 90 35 a a DET fnp-5195 90 36 dense dense ADJ fnp-5195 90 37 network network NOUN fnp-5195 90 38 of of ADP fnp-5195 90 39 thin thin ADJ fnp-5195 90 40 process process NOUN fnp-5195 90 41 in in ADP fnp-5195 90 42 ca1 ca1 PROPN fnp-5195 90 43 . . PUNCT fnp-5195 91 1 tau tau PROPN fnp-5195 91 2 labeled label VERB fnp-5195 91 3 neurofibrillary neurofibrillary ADJ fnp-5195 91 4 tangles tangle NOUN fnp-5195 91 5 in in ADP fnp-5195 91 6 the the DET fnp-5195 91 7 entorhinal entorhinal ADJ fnp-5195 91 8 cortex cortex NOUN fnp-5195 91 9 and and CCONJ fnp-5195 91 10 the the DET fnp-5195 91 11 locus locus NOUN fnp-5195 91 12 ceruleus ceruleus NOUN fnp-5195 91 13 , , PUNCT fnp-5195 91 14 and and CCONJ fnp-5195 91 15 plaque plaque NOUN fnp-5195 91 16 - - PUNCT fnp-5195 91 17 like like ADJ fnp-5195 91 18 structures structure NOUN fnp-5195 91 19 in in ADP fnp-5195 91 20 the the DET fnp-5195 91 21 absence absence NOUN fnp-5195 91 22 of of ADP fnp-5195 91 23 amyloid amyloid NOUN fnp-5195 91 24 in in ADP fnp-5195 91 25 the the DET fnp-5195 91 26 hippocampus hippocampus NOUN fnp-5195 91 27 . . PUNCT fnp-5195 92 1 beta beta ADJ fnp-5195 92 2 amyloid amyloid NOUN fnp-5195 92 3 plaques plaque NOUN fnp-5195 92 4 were be AUX fnp-5195 92 5 moderately moderately ADV fnp-5195 92 6 dense dense ADJ fnp-5195 92 7 in in ADP fnp-5195 92 8 the the DET fnp-5195 92 9 neocortex neocortex NOUN fnp-5195 92 10 , , PUNCT fnp-5195 92 11 and and CCONJ fnp-5195 92 12 accompanied accompany VERB fnp-5195 92 13 by by ADP fnp-5195 92 14 vascular vascular ADJ fnp-5195 92 15 deposits deposit NOUN fnp-5195 92 16 in in ADP fnp-5195 92 17 the the DET fnp-5195 92 18 occipital occipital ADJ fnp-5195 92 19 cortex cortex NOUN fnp-5195 92 20 only only ADV fnp-5195 92 21 . . PUNCT fnp-5195 93 1 alpha alpha NOUN fnp-5195 93 2 - - PUNCT fnp-5195 93 3 synuclein synuclein NOUN fnp-5195 93 4 lewy lewy PROPN fnp-5195 93 5 bodies body NOUN fnp-5195 93 6 were be AUX fnp-5195 93 7 present present ADJ fnp-5195 93 8 in in ADP fnp-5195 93 9 the the DET fnp-5195 93 10 locus locus NOUN fnp-5195 93 11 ceruleus ceruleus NOUN fnp-5195 93 12 , , PUNCT fnp-5195 93 13 but but CCONJ fnp-5195 93 14 not not PART fnp-5195 93 15 the the DET fnp-5195 93 16 substantia substantia NOUN fnp-5195 93 17 nigra nigra NOUN fnp-5195 93 18 . . PUNCT fnp-5195 94 1 the the DET fnp-5195 94 2 surprising surprising ADJ fnp-5195 94 3 findings finding NOUN fnp-5195 94 4 were be AUX fnp-5195 94 5 the the DET fnp-5195 94 6 extent extent NOUN fnp-5195 94 7 of of ADP fnp-5195 94 8 hippocampal hippocampal ADJ fnp-5195 94 9 lesions lesion NOUN fnp-5195 94 10 compatible compatible ADJ fnp-5195 94 11 with with ADP fnp-5195 94 12 near near ADJ fnp-5195 94 13 normal normal ADJ fnp-5195 94 14 function function NOUN fnp-5195 94 15 , , PUNCT fnp-5195 94 16 and and CCONJ fnp-5195 94 17 the the DET fnp-5195 94 18 severe severe ADJ fnp-5195 94 19 cortical cortical ADJ fnp-5195 94 20 astrocytosis astrocytosis NOUN fnp-5195 94 21 out out ADP fnp-5195 94 22 of of ADP fnp-5195 94 23 proportion proportion NOUN fnp-5195 94 24 to to ADP fnp-5195 94 25 abnormal abnormal ADJ fnp-5195 94 26 protein protein NOUN fnp-5195 94 27 deposits deposit NOUN fnp-5195 94 28 or or CCONJ fnp-5195 94 29 neuronal neuronal ADJ fnp-5195 94 30 loss loss NOUN fnp-5195 94 31 . . PUNCT fnp-5195 95 1 we we PRON fnp-5195 95 2 propose propose VERB fnp-5195 95 3 that that DET fnp-5195 95 4 astrocytosis astrocytosis NOUN fnp-5195 95 5 may may AUX fnp-5195 95 6 develop develop VERB fnp-5195 95 7 in in ADP fnp-5195 95 8 response response NOUN fnp-5195 95 9 to to ADP fnp-5195 95 10 neuronal neuronal ADJ fnp-5195 95 11 tdp-43 tdp-43 NOUN fnp-5195 95 12 , , PUNCT fnp-5195 95 13 made make VERB fnp-5195 95 14 conspicuous conspicuous ADJ fnp-5195 95 15 by by ADP fnp-5195 95 16 ageing age VERB fnp-5195 95 17 , , PUNCT fnp-5195 95 18 and and CCONJ fnp-5195 95 19 play play VERB fnp-5195 95 20 a a DET fnp-5195 95 21 neuroprotective neuroprotective ADJ fnp-5195 95 22 role role NOUN fnp-5195 95 23 , , PUNCT fnp-5195 95 24 as as SCONJ fnp-5195 95 25 postulated postulate VERB fnp-5195 95 26 in in ADP fnp-5195 95 27 als al NOUN fnp-5195 95 28 . . PUNCT fnp-5195 95 29     SPACE fnp-5195 96 1 abstract abstract ADJ fnp-5195 96 2 8 8 NUM fnp-5195 96 3 free free ADJ fnp-5195 96 4 neuropathol neuropathol NOUN fnp-5195 96 5 4:20:11 4:20:11 NUM fnp-5195 96 6 cellular cellular ADJ fnp-5195 96 7 activation activation NOUN fnp-5195 96 8 patterns pattern NOUN fnp-5195 96 9 of of ADP fnp-5195 96 10 cd10 cd10 PROPN fnp-5195 96 11 + + CCONJ fnp-5195 96 12 fibro fibro PROPN fnp-5195 96 13 - - PUNCT fnp-5195 96 14 adipogenic adipogenic ADJ fnp-5195 96 15 progenitors progenitor NOUN fnp-5195 96 16 across across ADP fnp-5195 96 17 acquired acquire VERB fnp-5195 96 18 disease disease NOUN fnp-5195 96 19 states state NOUN fnp-5195 96 20 in in ADP fnp-5195 96 21 human human ADJ fnp-5195 96 22 skeletal skeletal ADJ fnp-5195 96 23 muscle muscle NOUN fnp-5195 96 24 biopsies biopsy NOUN fnp-5195 96 25 peter peter PROPN fnp-5195 96 26 w. w. PROPN fnp-5195 96 27 schutz1 schutz1 PROPN fnp-5195 96 28 , , PUNCT fnp-5195 96 29 simon simon PROPN fnp-5195 96 30 cheung1 cheung1 PROPN fnp-5195 96 31 , , PUNCT fnp-5195 96 32 lin lin PROPN fnp-5195 96 33 yi2 yi2 PROPN fnp-5195 96 34 , , PUNCT fnp-5195 96 35 fabio fabio PROPN fnp-5195 96 36 m.v m.v PROPN fnp-5195 96 37 . . PUNCT fnp-5195 97 1 rossi2 rossi2 PROPN fnp-5195 97 2 1 1 NUM fnp-5195 97 3 department department NOUN fnp-5195 97 4 of of ADP fnp-5195 97 5 pathology pathology PROPN fnp-5195 97 6 , , PUNCT fnp-5195 97 7 university university PROPN fnp-5195 97 8 of of ADP fnp-5195 97 9 british british PROPN fnp-5195 97 10 columbia columbia PROPN fnp-5195 97 11 and and CCONJ fnp-5195 97 12 vancouver vancouver PROPN fnp-5195 97 13 general general PROPN fnp-5195 97 14 hospital hospital PROPN fnp-5195 97 15 , , PUNCT fnp-5195 97 16 vancouver vancouver PROPN fnp-5195 97 17 , , PUNCT fnp-5195 97 18 bc bc PROPN fnp-5195 97 19 , , PUNCT fnp-5195 97 20 v6 v6 PROPN fnp-5195 97 21 t t PROPN fnp-5195 97 22     SPACE fnp-5195 97 23 2b5 2b5 PROPN fnp-5195 97 24 , , PUNCT fnp-5195 97 25 canada canada PROPN fnp-5195 97 26 2 2 NUM fnp-5195 97 27 biomedical biomedical ADJ fnp-5195 97 28 research research NOUN fnp-5195 97 29 centre centre NOUN fnp-5195 97 30 , , PUNCT fnp-5195 97 31 university university NOUN fnp-5195 97 32 of of ADP fnp-5195 97 33 british british PROPN fnp-5195 97 34 columbia columbia PROPN fnp-5195 97 35 , , PUNCT fnp-5195 97 36 vancouver vancouver PROPN fnp-5195 97 37 , , PUNCT fnp-5195 97 38 bc bc PROPN fnp-5195 97 39 , , PUNCT fnp-5195 97 40 v6 v6 PROPN fnp-5195 97 41 t t PROPN fnp-5195 97 42     SPACE fnp-5195 97 43 1z3 1z3 NUM fnp-5195 97 44 , , PUNCT fnp-5195 97 45 canada canada PROPN fnp-5195 97 46 background background NOUN fnp-5195 97 47 : : PUNCT fnp-5195 97 48 fibro fibro NOUN fnp-5195 97 49 - - PUNCT fnp-5195 97 50 adipogenic adipogenic ADJ fnp-5195 97 51 progenitors progenitor NOUN fnp-5195 97 52 ( ( PUNCT fnp-5195 97 53 fap fap NOUN fnp-5195 97 54 ) ) PUNCT fnp-5195 97 55 are be AUX fnp-5195 97 56 resident resident ADJ fnp-5195 97 57 mesenchymal mesenchymal NOUN fnp-5195 97 58 stem stem NOUN fnp-5195 97 59 cells cell NOUN fnp-5195 97 60 of of ADP fnp-5195 97 61 skeletal skeletal ADJ fnp-5195 97 62 muscle muscle NOUN fnp-5195 97 63 with with ADP fnp-5195 97 64 defined define VERB fnp-5195 97 65 roles role NOUN fnp-5195 97 66 in in ADP fnp-5195 97 67 muscle muscle NOUN fnp-5195 97 68 fiber fiber NOUN fnp-5195 97 69 repair repair NOUN fnp-5195 97 70 and and CCONJ fnp-5195 97 71 fibrosis fibrosis NOUN fnp-5195 97 72 . . PUNCT fnp-5195 98 1 experimental experimental ADJ fnp-5195 98 2 studies study NOUN fnp-5195 98 3 have have AUX fnp-5195 98 4 shown show VERB fnp-5195 98 5 their their PRON fnp-5195 98 6 involvement involvement NOUN fnp-5195 98 7 in in ADP fnp-5195 98 8 fibrofatty fibrofatty ADJ fnp-5195 98 9 degeneration degeneration NOUN fnp-5195 98 10 , , PUNCT fnp-5195 98 11 denervation denervation NOUN fnp-5195 98 12 atrophy atrophy NOUN fnp-5195 98 13 , , PUNCT fnp-5195 98 14 and and CCONJ fnp-5195 98 15 their their PRON fnp-5195 98 16 susceptibility susceptibility NOUN fnp-5195 98 17 for for ADP fnp-5195 98 18 pharmacological pharmacological ADJ fnp-5195 98 19 intervention intervention NOUN fnp-5195 98 20 . . PUNCT fnp-5195 99 1 fap fap NOUN fnp-5195 99 2 reaction reaction NOUN fnp-5195 99 3 patterns pattern NOUN fnp-5195 99 4 in in ADP fnp-5195 99 5 human human ADJ fnp-5195 99 6 muscle muscle NOUN fnp-5195 99 7 biopsies biopsy NOUN fnp-5195 99 8 are be AUX fnp-5195 99 9 largely largely ADV fnp-5195 99 10 unknown unknown ADJ fnp-5195 99 11 , , PUNCT fnp-5195 99 12 but but CCONJ fnp-5195 99 13 have have VERB fnp-5195 99 14 potential potential NOUN fnp-5195 99 15 to to PART fnp-5195 99 16 inform inform VERB fnp-5195 99 17 translational translational ADJ fnp-5195 99 18 approaches approach NOUN fnp-5195 99 19 . . PUNCT fnp-5195 100 1 method method NOUN fnp-5195 100 2 : : PUNCT fnp-5195 100 3 32 32 NUM fnp-5195 100 4 muscle muscle NOUN fnp-5195 100 5 biopsies biopsy NOUN fnp-5195 100 6 from from ADP fnp-5195 100 7 the the DET fnp-5195 100 8 archives archive NOUN fnp-5195 100 9 of of ADP fnp-5195 100 10 vancouver vancouver PROPN fnp-5195 100 11 general general PROPN fnp-5195 100 12 hospital hospital NOUN fnp-5195 100 13 were be AUX fnp-5195 100 14 selected select VERB fnp-5195 100 15 from from ADP fnp-5195 100 16 8 8 NUM fnp-5195 100 17 groups group NOUN fnp-5195 100 18 ( ( PUNCT fnp-5195 100 19 normal normal ADJ fnp-5195 100 20 , , PUNCT fnp-5195 100 21 dermatomyositis dermatomyositis PROPN fnp-5195 100 22 , , PUNCT fnp-5195 100 23 ibm ibm PROPN fnp-5195 100 24 , , PUNCT fnp-5195 100 25 anti anti ADJ fnp-5195 100 26 - - ADJ fnp-5195 100 27 synthetase synthetase ADJ fnp-5195 100 28 syndrome syndrome NOUN fnp-5195 100 29 , , PUNCT fnp-5195 100 30 imnm imnm PROPN fnp-5195 100 31 , , PUNCT fnp-5195 100 32 denervation denervation NOUN fnp-5195 100 33 , , PUNCT fnp-5195 100 34 type type NOUN fnp-5195 100 35 2 2 NUM fnp-5195 100 36 atrophy atrophy NOUN fnp-5195 100 37 , , PUNCT fnp-5195 100 38 rhabdomyolysis rhabdomyolysis NOUN fnp-5195 100 39 ) ) PUNCT fnp-5195 100 40 . . PUNCT fnp-5195 101 1 fap fap NOUN fnp-5195 101 2 reaction reaction NOUN fnp-5195 101 3 patterns pattern NOUN fnp-5195 101 4 were be AUX fnp-5195 101 5 analysed analyse VERB fnp-5195 101 6 on on ADP fnp-5195 101 7 routine routine ADJ fnp-5195 101 8 cd10 cd10 PROPN fnp-5195 101 9 immunohistochemical immunohistochemical ADJ fnp-5195 101 10 staining staining NOUN fnp-5195 101 11 and and CCONJ fnp-5195 101 12 compared compare VERB fnp-5195 101 13 between between ADP fnp-5195 101 14 groups group NOUN fnp-5195 101 15 . . PUNCT fnp-5195 102 1 double double ADJ fnp-5195 102 2 staining stain VERB fnp-5195 102 3 with with ADP fnp-5195 102 4 mxa mxa NOUN fnp-5195 102 5 was be AUX fnp-5195 102 6 performed perform VERB fnp-5195 102 7 on on ADP fnp-5195 102 8 a a DET fnp-5195 102 9 subset subset NOUN fnp-5195 102 10 . . PUNCT fnp-5195 103 1 groups group NOUN fnp-5195 103 2 were be AUX fnp-5195 103 3 compared compare VERB fnp-5195 103 4 histologically histologically ADV fnp-5195 103 5 and and CCONJ fnp-5195 103 6 by by ADP fnp-5195 103 7 semi semi ADJ fnp-5195 103 8 - - ADJ fnp-5195 103 9 quantitative quantitative ADJ fnp-5195 103 10 scoring scoring NOUN fnp-5195 103 11 . . PUNCT fnp-5195 104 1 results result NOUN fnp-5195 104 2 : : PUNCT fnp-5195 104 3 activated activate VERB fnp-5195 104 4 endomysial endomysial ADJ fnp-5195 104 5 cd10 cd10 PROPN fnp-5195 104 6 + + CCONJ fnp-5195 104 7 faps fap NOUN fnp-5195 104 8 showed show VERB fnp-5195 104 9 thickening thickening NOUN fnp-5195 104 10 and and CCONJ fnp-5195 104 11 expansion expansion NOUN fnp-5195 104 12 of of ADP fnp-5195 104 13 their their PRON fnp-5195 104 14 normally normally ADV fnp-5195 104 15 delicate delicate ADJ fnp-5195 104 16 cell cell NOUN fnp-5195 104 17 processes process NOUN fnp-5195 104 18 surrounding surround VERB fnp-5195 104 19 muscle muscle NOUN fnp-5195 104 20 fibers fiber NOUN fnp-5195 104 21 , , PUNCT fnp-5195 104 22 and and CCONJ fnp-5195 104 23 endomysial endomysial ADJ fnp-5195 104 24 cell cell NOUN fnp-5195 104 25 clusters cluster NOUN fnp-5195 104 26 evidencing evidencing NOUN fnp-5195 104 27 proliferation proliferation NOUN fnp-5195 104 28 . . PUNCT fnp-5195 105 1 comparison comparison NOUN fnp-5195 105 2 across across ADP fnp-5195 105 3 groups group NOUN fnp-5195 105 4 confirms confirm VERB fnp-5195 105 5 fap fap NOUN fnp-5195 105 6 activation activation NOUN fnp-5195 105 7 in in ADP fnp-5195 105 8 association association NOUN fnp-5195 105 9 with with ADP fnp-5195 105 10 fiber fiber NOUN fnp-5195 105 11 degeneration degeneration NOUN fnp-5195 105 12 / / SYM fnp-5195 105 13 regeneration regeneration NOUN fnp-5195 105 14 , , PUNCT fnp-5195 105 15 foci focus NOUN fnp-5195 105 16 of of ADP fnp-5195 105 17 inflammation inflammation NOUN fnp-5195 105 18 , , PUNCT fnp-5195 105 19 and and CCONJ fnp-5195 105 20 denervation denervation NOUN fnp-5195 105 21 , , PUNCT fnp-5195 105 22 in in ADP fnp-5195 105 23 keeping keep VERB fnp-5195 105 24 with with ADP fnp-5195 105 25 experimental experimental ADJ fnp-5195 105 26 results result NOUN fnp-5195 105 27 . . PUNCT fnp-5195 106 1 unexpectedly unexpectedly ADV fnp-5195 106 2 , , PUNCT fnp-5195 106 3 dermatomyositis dermatomyositis NOUN fnp-5195 106 4 and and CCONJ fnp-5195 106 5 anti anti ADJ fnp-5195 106 6 - - ADJ fnp-5195 106 7 synthetase synthetase ADJ fnp-5195 106 8 biopsies biopsy NOUN fnp-5195 106 9 show show VERB fnp-5195 106 10 diffuse diffuse NOUN fnp-5195 106 11 activation activation NOUN fnp-5195 106 12 . . PUNCT fnp-5195 107 1 fap fap NOUN fnp-5195 107 2 activation activation NOUN fnp-5195 107 3 in in ADP fnp-5195 107 4 dermatomyositis dermatomyositis PROPN fnp-5195 107 5 coincided coincide VERB fnp-5195 107 6 with with ADP fnp-5195 107 7 sarcoplasmic sarcoplasmic ADJ fnp-5195 107 8 mxa mxa NOUN fnp-5195 107 9 expression expression NOUN fnp-5195 107 10 . . PUNCT fnp-5195 108 1 conclusion conclusion NOUN fnp-5195 108 2 : : PUNCT fnp-5195 108 3 assessment assessment NOUN fnp-5195 108 4 of of ADP fnp-5195 108 5 cd10 cd10 PROPN fnp-5195 108 6 + + NOUN fnp-5195 108 7 fap fap NOUN fnp-5195 108 8 activation activation NOUN fnp-5195 108 9 is be AUX fnp-5195 108 10 routinely routinely ADV fnp-5195 108 11 possible possible ADJ fnp-5195 108 12 using use VERB fnp-5195 108 13 cd10 cd10 PROPN fnp-5195 108 14 immunohistochemistry immunohistochemistry NOUN fnp-5195 108 15 and and CCONJ fnp-5195 108 16 demonstrates demonstrate VERB fnp-5195 108 17 cellular cellular ADJ fnp-5195 108 18 fap fap NOUN fnp-5195 108 19 reaction reaction NOUN fnp-5195 108 20 patterns pattern NOUN fnp-5195 108 21 often often ADV fnp-5195 108 22 in in ADP fnp-5195 108 23 keeping keep VERB fnp-5195 108 24 with with ADP fnp-5195 108 25 preclinical preclinical ADJ fnp-5195 108 26 results result NOUN fnp-5195 108 27 . . PUNCT fnp-5195 109 1 prominent prominent ADJ fnp-5195 109 2 expansion expansion NOUN fnp-5195 109 3 of of ADP fnp-5195 109 4 fap fap NOUN fnp-5195 109 5 processes process NOUN fnp-5195 109 6 surrounding surround VERB fnp-5195 109 7 myofibers myofiber NOUN fnp-5195 109 8 suggests suggest VERB fnp-5195 109 9 enhanced enhanced ADJ fnp-5195 109 10 interaction interaction NOUN fnp-5195 109 11 between between ADP fnp-5195 109 12 myofiber myofiber PROPN fnp-5195 109 13 / / SYM fnp-5195 109 14 basement basement NOUN fnp-5195 109 15 membranes membrane NOUN fnp-5195 109 16 and and CCONJ fnp-5195 109 17 faps fap NOUN fnp-5195 109 18 during during ADP fnp-5195 109 19 activation activation NOUN fnp-5195 109 20 . . PUNCT fnp-5195 110 1 the the DET fnp-5195 110 2 presence presence NOUN fnp-5195 110 3 of of ADP fnp-5195 110 4 diffuse diffuse ADJ fnp-5195 110 5 fap fap NOUN fnp-5195 110 6 activation activation NOUN fnp-5195 110 7 in in ADP fnp-5195 110 8 dermatomyositis dermatomyositis PROPN fnp-5195 110 9 and and CCONJ fnp-5195 110 10 anti anti ADJ fnp-5195 110 11 - - ADJ fnp-5195 110 12 synthetase synthetase ADJ fnp-5195 110 13 biopsies biopsy NOUN fnp-5195 110 14 raises raise VERB fnp-5195 110 15 the the DET fnp-5195 110 16 possibility possibility NOUN fnp-5195 110 17 of of ADP fnp-5195 110 18 fap fap NOUN fnp-5195 110 19 activation activation NOUN fnp-5195 110 20 as as ADP fnp-5195 110 21 part part NOUN fnp-5195 110 22 of of ADP fnp-5195 110 23 the the DET fnp-5195 110 24 autoimmune autoimmune ADJ fnp-5195 110 25 process process NOUN fnp-5195 110 26 . . PUNCT fnp-5195 111 1 future future ADJ fnp-5195 111 2 diagnostic diagnostic ADJ fnp-5195 111 3 applications application NOUN fnp-5195 111 4 , , PUNCT fnp-5195 111 5 clinical clinical ADJ fnp-5195 111 6 significance significance NOUN fnp-5195 111 7 and and CCONJ fnp-5195 111 8 therapeutic therapeutic ADJ fnp-5195 111 9 potential potential NOUN fnp-5195 111 10 remain remain VERB fnp-5195 111 11 open open ADJ fnp-5195 111 12 questions question NOUN fnp-5195 111 13 . . PUNCT fnp-5195 111 14     SPACE fnp-5195 112 1 abstract abstract ADJ fnp-5195 112 2 9 9 NUM fnp-5195 112 3 free free ADJ fnp-5195 112 4 neuropathol neuropathol NOUN fnp-5195 112 5 4:20:12 4:20:12 NUM fnp-5195 112 6 assessment assessment NOUN fnp-5195 112 7 challenges challenge NOUN fnp-5195 112 8 and and CCONJ fnp-5195 112 9 headaches headache NOUN fnp-5195 112 10 in in ADP fnp-5195 112 11 the the DET fnp-5195 112 12 implementation implementation NOUN fnp-5195 112 13 of of ADP fnp-5195 112 14 competence competence NOUN fnp-5195 112 15 by by ADP fnp-5195 112 16 design design NOUN fnp-5195 112 17 ( ( PUNCT fnp-5195 112 18 cbd cbd NOUN fnp-5195 112 19 ): ): PUNCT fnp-5195 112 20 the the DET fnp-5195 112 21 experience experience NOUN fnp-5195 112 22 in in ADP fnp-5195 112 23 a a DET fnp-5195 112 24 diagnostic diagnostic ADJ fnp-5195 112 25 and and CCONJ fnp-5195 112 26 molecular molecular ADJ fnp-5195 112 27 pathology pathology NOUN fnp-5195 112 28 residency residency NOUN fnp-5195 112 29 program program NOUN fnp-5195 112 30 hao hao PROPN fnp-5195 112 31 li1 li1 PROPN fnp-5195 112 32 , , PUNCT fnp-5195 112 33 sarah sarah PROPN fnp-5195 112 34 j. j. PROPN fnp-5195 112 35 aziz1 aziz1 PROPN fnp-5195 112 36 , , PUNCT fnp-5195 112 37 lindsay lindsay PROPN fnp-5195 112 38 ninivirta1 ninivirta1 PROPN fnp-5195 112 39 , , PUNCT fnp-5195 112 40 louise louise PROPN fnp-5195 112 41 mui1 mui1 PROPN fnp-5195 112 42 , , PUNCT fnp-5195 112 43 david david PROPN fnp-5195 112 44 k. k. PROPN fnp-5195 112 45 driman1 driman1 PROPN fnp-5195 112 46 , , PUNCT fnp-5195 112 47 christopher christopher PROPN fnp-5195 112 48 j. j. PROPN fnp-5195 112 49 watling2 watling2 PROPN fnp-5195 112 50 , , PUNCT fnp-5195 112 51 emily emily PROPN fnp-5195 112 52 a. a. NOUN fnp-5195 112 53 goebel1 goebel1 PROPN fnp-5195 112 54 1 1 NUM fnp-5195 112 55 pathology pathology NOUN fnp-5195 112 56 and and CCONJ fnp-5195 112 57 laboratory laboratory NOUN fnp-5195 112 58 medicine medicine NOUN fnp-5195 112 59 , , PUNCT fnp-5195 112 60 schulich schulich PROPN fnp-5195 112 61 school school NOUN fnp-5195 112 62 of of ADP fnp-5195 112 63 medicine medicine PROPN fnp-5195 112 64 & & CCONJ fnp-5195 112 65 dentistry dentistry PROPN fnp-5195 112 66 , , PUNCT fnp-5195 112 67 western western ADJ fnp-5195 112 68 university university NOUN fnp-5195 112 69 , , PUNCT fnp-5195 112 70 london london PROPN fnp-5195 112 71 , , PUNCT fnp-5195 112 72 on on ADP fnp-5195 112 73 , , PUNCT fnp-5195 112 74 canada canada PROPN fnp-5195 112 75 2 2 NUM fnp-5195 112 76 centre centre NOUN fnp-5195 112 77 for for ADP fnp-5195 112 78 education education NOUN fnp-5195 112 79 research research NOUN fnp-5195 112 80 & & CCONJ fnp-5195 112 81 innovation innovation NOUN fnp-5195 112 82 , , PUNCT fnp-5195 112 83 western western ADJ fnp-5195 112 84 university university NOUN fnp-5195 112 85 , , PUNCT fnp-5195 112 86 london london PROPN fnp-5195 112 87 , , PUNCT fnp-5195 112 88 on on ADP fnp-5195 112 89 , , PUNCT fnp-5195 112 90 canada canada PROPN fnp-5195 112 91 background background NOUN fnp-5195 112 92 / / SYM fnp-5195 112 93 objectives objective NOUN fnp-5195 112 94 : : PUNCT fnp-5195 112 95 the the DET fnp-5195 112 96 recent recent ADJ fnp-5195 112 97 implementation implementation NOUN fnp-5195 112 98 of of ADP fnp-5195 112 99 competence competence NOUN fnp-5195 112 100 by by ADP fnp-5195 112 101 design design NOUN fnp-5195 112 102 ( ( PUNCT fnp-5195 112 103 cbd cbd NOUN fnp-5195 112 104 ) ) PUNCT fnp-5195 112 105 in in ADP fnp-5195 112 106 neuropathology neuropathology NOUN fnp-5195 112 107 residency residency NOUN fnp-5195 112 108 creates create VERB fnp-5195 112 109 changes change NOUN fnp-5195 112 110 in in ADP fnp-5195 112 111 both both DET fnp-5195 112 112 education education NOUN fnp-5195 112 113 philosophy philosophy NOUN fnp-5195 112 114 and and CCONJ fnp-5195 112 115 practical practical ADJ fnp-5195 112 116 administration administration NOUN fnp-5195 112 117 . . PUNCT fnp-5195 113 1 this this DET fnp-5195 113 2 study study NOUN fnp-5195 113 3 analyzes analyze VERB fnp-5195 113 4 perceptions perception NOUN fnp-5195 113 5 of of ADP fnp-5195 113 6 specific specific ADJ fnp-5195 113 7 assessment assessment NOUN fnp-5195 113 8 criteria criterion NOUN fnp-5195 113 9 in in ADP fnp-5195 113 10 cbd cbd NOUN fnp-5195 113 11 at at ADP fnp-5195 113 12 one one NUM fnp-5195 113 13 diagnostic diagnostic ADJ fnp-5195 113 14 and and CCONJ fnp-5195 113 15 molecular molecular ADJ fnp-5195 113 16 pathology pathology NOUN fnp-5195 113 17 ( ( PUNCT fnp-5195 113 18 formerly formerly ADV fnp-5195 113 19 anatomical anatomical ADJ fnp-5195 113 20 pathology pathology NOUN fnp-5195 113 21 ) ) PUNCT fnp-5195 113 22 residency residency NOUN fnp-5195 113 23 program program NOUN fnp-5195 113 24 , , PUNCT fnp-5195 113 25 and and CCONJ fnp-5195 113 26 the the DET fnp-5195 113 27 lessons lesson NOUN fnp-5195 113 28 learned learn VERB fnp-5195 113 29 . . PUNCT fnp-5195 114 1 methodology methodology NOUN fnp-5195 114 2 : : PUNCT fnp-5195 115 1 we we PRON fnp-5195 115 2 focused focus VERB fnp-5195 115 3 on on ADP fnp-5195 115 4 assessment assessment NOUN fnp-5195 115 5 interpretation interpretation NOUN fnp-5195 115 6 of of ADP fnp-5195 115 7 transition transition NOUN fnp-5195 115 8 to to PART fnp-5195 115 9 discipline discipline NOUN fnp-5195 115 10 ( ( PUNCT fnp-5195 115 11 ttd ttd NOUN fnp-5195 115 12 ) ) PUNCT fnp-5195 115 13 entrustable entrustable ADJ fnp-5195 115 14 professional professional ADJ fnp-5195 115 15 activities activity NOUN fnp-5195 115 16 ( ( PUNCT fnp-5195 115 17 epas epas PROPN fnp-5195 115 18 ) ) PUNCT fnp-5195 115 19 , , PUNCT fnp-5195 115 20 which which PRON fnp-5195 115 21 overlap overlap VERB fnp-5195 115 22 with with ADP fnp-5195 115 23 those those PRON fnp-5195 115 24 in in ADP fnp-5195 115 25 neuropathology neuropathology NOUN fnp-5195 115 26 – – PUNCT fnp-5195 115 27 basic basic ADJ fnp-5195 115 28 specimen speciman NOUN fnp-5195 115 29 handling handling NOUN fnp-5195 115 30 , , PUNCT fnp-5195 115 31 basic basic ADJ fnp-5195 115 32 microscopy microscopy NOUN fnp-5195 115 33 , , PUNCT fnp-5195 115 34 and and CCONJ fnp-5195 115 35 summarizing summarize VERB fnp-5195 115 36 clinical clinical ADJ fnp-5195 115 37 information information NOUN fnp-5195 115 38 for for ADP fnp-5195 115 39 clinicopathologic clinicopathologic ADJ fnp-5195 115 40 correlation correlation NOUN fnp-5195 115 41 . . PUNCT fnp-5195 116 1 eight eight NUM fnp-5195 116 2 pathology pathology NOUN fnp-5195 116 3 faculty faculty NOUN fnp-5195 116 4 were be AUX fnp-5195 116 5 interviewed interview VERB fnp-5195 116 6 . . PUNCT fnp-5195 117 1 they they PRON fnp-5195 117 2 were be AUX fnp-5195 117 3 first first ADV fnp-5195 117 4 shown show VERB fnp-5195 117 5 the the DET fnp-5195 117 6 epa epa PROPN fnp-5195 117 7 titles title NOUN fnp-5195 117 8 only only ADV fnp-5195 117 9 ( ( PUNCT fnp-5195 117 10 “ " PUNCT fnp-5195 117 11 gestalt gestalt NOUN fnp-5195 117 12 ” " PUNCT fnp-5195 117 13 impression impression NOUN fnp-5195 117 14 ) ) PUNCT fnp-5195 117 15 , , PUNCT fnp-5195 117 16 then then ADV fnp-5195 117 17 the the DET fnp-5195 117 18 full full ADJ fnp-5195 117 19 descriptions description NOUN fnp-5195 117 20 , , PUNCT fnp-5195 117 21 and and CCONJ fnp-5195 117 22 expressed express VERB fnp-5195 117 23 their their PRON fnp-5195 117 24 perceived perceive VERB fnp-5195 117 25 expectations expectation NOUN fnp-5195 117 26 of of ADP fnp-5195 117 27 the the DET fnp-5195 117 28 epas epa NOUN fnp-5195 117 29 during during ADP fnp-5195 117 30 each each DET fnp-5195 117 31 phase phase NOUN fnp-5195 117 32 . . PUNCT fnp-5195 118 1 interviews interview NOUN fnp-5195 118 2 were be AUX fnp-5195 118 3 recorded record VERB fnp-5195 118 4 , , PUNCT fnp-5195 118 5 transcribed transcribe VERB fnp-5195 118 6 , , PUNCT fnp-5195 118 7 and and CCONJ fnp-5195 118 8 subjected subject VERB fnp-5195 118 9 to to ADP fnp-5195 118 10 thematic thematic ADJ fnp-5195 118 11 analysis analysis NOUN fnp-5195 118 12 . . PUNCT fnp-5195 119 1 results result NOUN fnp-5195 119 2 : : PUNCT fnp-5195 119 3 the the DET fnp-5195 119 4 gestalt gestalt NOUN fnp-5195 119 5 impression impression NOUN fnp-5195 119 6 of of ADP fnp-5195 119 7 specimen speciman NOUN fnp-5195 119 8 handling handle VERB fnp-5195 119 9 and and CCONJ fnp-5195 119 10 microscopy microscopy NOUN fnp-5195 119 11 epas epa NOUN fnp-5195 119 12 varied vary VERB fnp-5195 119 13 widely widely ADV fnp-5195 119 14 in in ADP fnp-5195 119 15 the the DET fnp-5195 119 16 expected expect VERB fnp-5195 119 17 level level NOUN fnp-5195 119 18 of of ADP fnp-5195 119 19 performance performance NOUN fnp-5195 119 20 at at ADP fnp-5195 119 21 a a DET fnp-5195 119 22 “ " PUNCT fnp-5195 119 23 basic basic ADJ fnp-5195 119 24 ” " PUNCT fnp-5195 119 25 stage stage NOUN fnp-5195 119 26 . . PUNCT fnp-5195 120 1 while while SCONJ fnp-5195 120 2 the the DET fnp-5195 120 3 descriptions description NOUN fnp-5195 120 4 clarified clarify VERB fnp-5195 120 5 expectations expectation NOUN fnp-5195 120 6 , , PUNCT fnp-5195 120 7 participants participant NOUN fnp-5195 120 8 disagreed disagree VERB fnp-5195 120 9 on on ADP fnp-5195 120 10 whether whether SCONJ fnp-5195 120 11 they they PRON fnp-5195 120 12 were be AUX fnp-5195 120 13 valid valid ADJ fnp-5195 120 14 and and CCONJ fnp-5195 120 15 complete complete ADJ fnp-5195 120 16 , , PUNCT fnp-5195 120 17 due due ADJ fnp-5195 120 18 to to ADP fnp-5195 120 19 contrasts contrast NOUN fnp-5195 120 20 with with ADP fnp-5195 120 21 their their PRON fnp-5195 120 22 own own ADJ fnp-5195 120 23 training training NOUN fnp-5195 120 24 experience experience NOUN fnp-5195 120 25 , , PUNCT fnp-5195 120 26 daily daily ADJ fnp-5195 120 27 work work NOUN fnp-5195 120 28 , , PUNCT fnp-5195 120 29 and and CCONJ fnp-5195 120 30 subspecialty subspecialty NOUN fnp-5195 120 31 niche niche NOUN fnp-5195 120 32 . . PUNCT fnp-5195 121 1 it it PRON fnp-5195 121 2 was be AUX fnp-5195 121 3 also also ADV fnp-5195 121 4 felt feel VERB fnp-5195 121 5 that that SCONJ fnp-5195 121 6 all all DET fnp-5195 121 7 epa epa PROPN fnp-5195 121 8 descriptions description NOUN fnp-5195 121 9 contained contain VERB fnp-5195 121 10 internal internal ADJ fnp-5195 121 11 inconsistencies inconsistency NOUN fnp-5195 121 12 that that PRON fnp-5195 121 13 were be AUX fnp-5195 121 14 challenging challenge VERB fnp-5195 121 15 to to PART fnp-5195 121 16 interpret interpret VERB fnp-5195 121 17 . . PUNCT fnp-5195 122 1 consequently consequently ADV fnp-5195 122 2 , , PUNCT fnp-5195 122 3 faculty faculty NOUN fnp-5195 122 4 described describe VERB fnp-5195 122 5 varying vary VERB fnp-5195 122 6 approaches approach NOUN fnp-5195 122 7 to to ADP fnp-5195 122 8 resident resident ADJ fnp-5195 122 9 assessment assessment NOUN fnp-5195 122 10 despite despite SCONJ fnp-5195 122 11 identical identical ADJ fnp-5195 122 12 criteria criterion NOUN fnp-5195 122 13 . . PUNCT fnp-5195 123 1 conclusions conclusion NOUN fnp-5195 123 2 : : PUNCT fnp-5195 123 3 our our PRON fnp-5195 123 4 findings finding NOUN fnp-5195 123 5 demonstrate demonstrate VERB fnp-5195 123 6 significant significant ADJ fnp-5195 123 7 subjectivity subjectivity NOUN fnp-5195 123 8 in in ADP fnp-5195 123 9 the the DET fnp-5195 123 10 interpretation interpretation NOUN fnp-5195 123 11 of of ADP fnp-5195 123 12 cbd cbd NOUN fnp-5195 123 13 epas epa NOUN fnp-5195 123 14 , , PUNCT fnp-5195 123 15 even even ADV fnp-5195 123 16 with with ADP fnp-5195 123 17 detailed detailed ADJ fnp-5195 123 18 assessment assessment NOUN fnp-5195 123 19 criteria criterion NOUN fnp-5195 123 20 . . PUNCT fnp-5195 124 1 this this PRON fnp-5195 124 2 is be AUX fnp-5195 124 3 due due ADJ fnp-5195 124 4 to to ADP fnp-5195 124 5 both both CCONJ fnp-5195 124 6 inadequate inadequate ADJ fnp-5195 124 7 clarity clarity NOUN fnp-5195 124 8 of of ADP fnp-5195 124 9 descriptions description NOUN fnp-5195 124 10 as as ADV fnp-5195 124 11 well well ADV fnp-5195 124 12 as as ADP fnp-5195 124 13 faculty faculty NOUN fnp-5195 124 14 attitudes attitude NOUN fnp-5195 124 15 and and CCONJ fnp-5195 124 16 biases bias NOUN fnp-5195 124 17 . . PUNCT fnp-5195 125 1 therefore therefore ADV fnp-5195 125 2 , , PUNCT fnp-5195 125 3 further further ADJ fnp-5195 125 4 refinement refinement NOUN fnp-5195 125 5 of of ADP fnp-5195 125 6 epa epa PROPN fnp-5195 125 7 descriptions description NOUN fnp-5195 125 8 may may AUX fnp-5195 125 9 be be AUX fnp-5195 125 10 necessary necessary ADJ fnp-5195 125 11 , , PUNCT fnp-5195 125 12 along along ADP fnp-5195 125 13 with with ADP fnp-5195 125 14 education education NOUN fnp-5195 125 15 of of ADP fnp-5195 125 16 faculty faculty NOUN fnp-5195 125 17 on on ADP fnp-5195 125 18 the the DET fnp-5195 125 19 underlying underlying ADJ fnp-5195 125 20 purpose purpose NOUN fnp-5195 125 21 of of ADP fnp-5195 125 22 each each DET fnp-5195 125 23 assessment assessment NOUN fnp-5195 125 24 item item NOUN fnp-5195 125 25 . . PUNCT fnp-5195 125 26     SPACE fnp-5195 126 1 abstract abstract ADJ fnp-5195 126 2 10 10 NUM fnp-5195 126 3 free free ADJ fnp-5195 126 4 neuropathol neuropathol NOUN fnp-5195 126 5 4:20:13 4:20:13 NUM fnp-5195 126 6 isolated isolate VERB fnp-5195 126 7 small small ADJ fnp-5195 126 8 vessel vessel NOUN fnp-5195 126 9 inflammation inflammation NOUN fnp-5195 126 10 in in ADP fnp-5195 126 11 temporal temporal ADJ fnp-5195 126 12 artery artery NOUN fnp-5195 126 13 biopsies biopsy NOUN fnp-5195 126 14 : : PUNCT fnp-5195 126 15 small small ADJ fnp-5195 126 16 red red ADJ fnp-5195 126 17 flags flag NOUN fnp-5195 126 18 shervin shervin PROPN fnp-5195 126 19 pejhan1 pejhan1 NOUN fnp-5195 126 20 , , PUNCT fnp-5195 126 21 lillian lillian PROPN fnp-5195 126 22 barra2 barra2 PROPN fnp-5195 126 23 , , PUNCT fnp-5195 126 24 pari pari PROPN fnp-5195 126 25 basharat2 basharat2 NOUN fnp-5195 126 26 , , PUNCT fnp-5195 126 27 larry larry PROPN fnp-5195 126 28 allen3 allen3 PROPN fnp-5195 126 29 , , PUNCT fnp-5195 126 30 lulu lulu PROPN fnp-5195 126 31 l.c.d l.c.d NOUN fnp-5195 126 32 . . PUNCT fnp-5195 127 1 bursztyn3,4 bursztyn3,4 PROPN fnp-5195 127 2 alain alain PROPN fnp-5195 127 3 proulx3 proulx3 PROPN fnp-5195 127 4 , , PUNCT fnp-5195 127 5 ruo ruo PROPN fnp-5195 127 6 yan yan PROPN fnp-5195 127 7 chen2 chen2 PROPN fnp-5195 127 8 , , PUNCT fnp-5195 127 9 morgan morgan PROPN fnp-5195 127 10 smith1 smith1 PROPN fnp-5195 127 11 , , PUNCT fnp-5195 127 12 montana montana PROPN fnp-5195 127 13 hackett5 hackett5 PROPN fnp-5195 127 14 , , PUNCT fnp-5195 127 15 robert robert PROPN fnp-5195 127 16 hammond1,4 hammond1,4 PROPN fnp-5195 127 17 1 1 NUM fnp-5195 127 18 department department NOUN fnp-5195 127 19 of of ADP fnp-5195 127 20 pathology pathology PROPN fnp-5195 127 21 & & CCONJ fnp-5195 127 22 lab lab PROPN fnp-5195 127 23 medicine medicine NOUN fnp-5195 127 24 , , PUNCT fnp-5195 127 25 london london PROPN fnp-5195 127 26 health health PROPN fnp-5195 127 27 sciences sciences PROPN fnp-5195 127 28 centre centre PROPN fnp-5195 127 29 , , PUNCT fnp-5195 127 30 schulich schulich PROPN fnp-5195 127 31 medicine medicine PROPN fnp-5195 127 32 & & CCONJ fnp-5195 127 33 dentistry dentistry PROPN fnp-5195 127 34 , , PUNCT fnp-5195 127 35 university university NOUN fnp-5195 127 36 of of ADP fnp-5195 127 37 western western PROPN fnp-5195 127 38 ontario ontario PROPN fnp-5195 127 39 , , PUNCT fnp-5195 127 40 london london PROPN fnp-5195 127 41 , , PUNCT fnp-5195 127 42 ontario ontario PROPN fnp-5195 127 43 , , PUNCT fnp-5195 127 44 canada canada PROPN fnp-5195 127 45 2 2 NUM fnp-5195 127 46 department department NOUN fnp-5195 127 47 of of ADP fnp-5195 127 48 medicine medicine NOUN fnp-5195 127 49 , , PUNCT fnp-5195 127 50 division division NOUN fnp-5195 127 51 of of ADP fnp-5195 127 52 rheumatology rheumatology NOUN fnp-5195 127 53 , , PUNCT fnp-5195 127 54 london london PROPN fnp-5195 127 55 health health PROPN fnp-5195 127 56 sciences sciences PROPN fnp-5195 127 57 centre centre PROPN fnp-5195 127 58 , , PUNCT fnp-5195 127 59 schulich schulich PROPN fnp-5195 127 60 medicine medicine PROPN fnp-5195 127 61 & & CCONJ fnp-5195 127 62 dentistry dentistry PROPN fnp-5195 127 63 , , PUNCT fnp-5195 127 64 university university NOUN fnp-5195 127 65 of of ADP fnp-5195 127 66 western western PROPN fnp-5195 127 67 ontario ontario PROPN fnp-5195 127 68 , , PUNCT fnp-5195 127 69 london london PROPN fnp-5195 127 70 , , PUNCT fnp-5195 127 71 ontario ontario PROPN fnp-5195 127 72 , , PUNCT fnp-5195 127 73 canada canada PROPN fnp-5195 127 74 3 3 NUM fnp-5195 127 75 ivey ivey PROPN fnp-5195 127 76 eye eye PROPN fnp-5195 127 77 institute institute PROPN fnp-5195 127 78 , , PUNCT fnp-5195 127 79 st st PROPN fnp-5195 127 80 . . PROPN fnp-5195 127 81 joseph joseph PROPN fnp-5195 127 82 's 's PART fnp-5195 127 83 hospital hospital NOUN fnp-5195 127 84 , , PUNCT fnp-5195 127 85 schulich schulich NOUN fnp-5195 127 86 medicine medicine PROPN fnp-5195 127 87 & & CCONJ fnp-5195 127 88 dentistry dentistry PROPN fnp-5195 127 89 , , PUNCT fnp-5195 127 90 university university NOUN fnp-5195 127 91 of of ADP fnp-5195 127 92 western western PROPN fnp-5195 127 93 ontario ontario PROPN fnp-5195 127 94 , , PUNCT fnp-5195 127 95 london london PROPN fnp-5195 127 96 , , PUNCT fnp-5195 127 97 ontario ontario PROPN fnp-5195 127 98 , , PUNCT fnp-5195 127 99 canada canada PROPN fnp-5195 127 100 4 4 NUM fnp-5195 127 101 department department NOUN fnp-5195 127 102 of of ADP fnp-5195 127 103 clinical clinical ADJ fnp-5195 127 104 neurological neurological ADJ fnp-5195 127 105 sciences science NOUN fnp-5195 127 106 , , PUNCT fnp-5195 127 107 london london PROPN fnp-5195 127 108 health health PROPN fnp-5195 127 109 sciences sciences PROPN fnp-5195 127 110 centre centre PROPN fnp-5195 127 111 , , PUNCT fnp-5195 127 112 schulich schulich PROPN fnp-5195 127 113 medicine medicine PROPN fnp-5195 127 114 & & CCONJ fnp-5195 127 115 dentistry dentistry PROPN fnp-5195 127 116 , , PUNCT fnp-5195 127 117 university university NOUN fnp-5195 127 118 of of ADP fnp-5195 127 119 western western PROPN fnp-5195 127 120 ontario ontario PROPN fnp-5195 127 121 , , PUNCT fnp-5195 127 122 london london PROPN fnp-5195 127 123 , , PUNCT fnp-5195 127 124 ontario ontario PROPN fnp-5195 127 125 , , PUNCT fnp-5195 127 126 canada canada PROPN fnp-5195 127 127 5 5 NUM fnp-5195 127 128 schulich schulich PROPN fnp-5195 127 129 medicine medicine NOUN fnp-5195 127 130 & & CCONJ fnp-5195 127 131 dentistry dentistry PROPN fnp-5195 127 132 , , PUNCT fnp-5195 127 133 university university NOUN fnp-5195 127 134 of of ADP fnp-5195 127 135 western western PROPN fnp-5195 127 136 ontario ontario PROPN fnp-5195 127 137 , , PUNCT fnp-5195 127 138 london london PROPN fnp-5195 127 139 , , PUNCT fnp-5195 127 140 ontario ontario PROPN fnp-5195 127 141 , , PUNCT fnp-5195 127 142 canada canada PROPN fnp-5195 127 143 temporal temporal ADJ fnp-5195 127 144 arteritis arteritis PROPN fnp-5195 127 145 ( ( PUNCT fnp-5195 127 146 ta ta NOUN fnp-5195 127 147 ) ) PUNCT fnp-5195 127 148 is be AUX fnp-5195 127 149 the the DET fnp-5195 127 150 most most ADV fnp-5195 127 151 common common ADJ fnp-5195 127 152 vasculitis vasculitis NOUN fnp-5195 127 153 over over ADP fnp-5195 127 154 age age NOUN fnp-5195 127 155 50 50 NUM fnp-5195 127 156 . . PUNCT fnp-5195 128 1 untreated untreate VERB fnp-5195 128 2 , , PUNCT fnp-5195 128 3 many many ADJ fnp-5195 128 4 patients patient NOUN fnp-5195 128 5 will will AUX fnp-5195 128 6 suffer suffer VERB fnp-5195 128 7 blindness blindness NOUN fnp-5195 128 8 or or CCONJ fnp-5195 128 9 stroke stroke NOUN fnp-5195 128 10 . . PUNCT fnp-5195 129 1 gold gold NOUN fnp-5195 129 2 standard standard ADJ fnp-5195 129 3 diagnosis diagnosis NOUN fnp-5195 129 4 is be AUX fnp-5195 129 5 achieved achieve VERB fnp-5195 129 6 by by ADP fnp-5195 129 7 temporal temporal ADJ fnp-5195 129 8 artery artery NOUN fnp-5195 129 9 biopsy biopsy NOUN fnp-5195 129 10 . . PUNCT fnp-5195 130 1 the the DET fnp-5195 130 2 aim aim NOUN fnp-5195 130 3 of of ADP fnp-5195 130 4 this this DET fnp-5195 130 5 research research NOUN fnp-5195 130 6 is be AUX fnp-5195 130 7 to to PART fnp-5195 130 8 investigate investigate VERB fnp-5195 130 9 the the DET fnp-5195 130 10 relevance relevance NOUN fnp-5195 130 11 of of ADP fnp-5195 130 12 small small ADJ fnp-5195 130 13 vessel vessel NOUN fnp-5195 130 14 inflammation inflammation NOUN fnp-5195 130 15 in in ADP fnp-5195 130 16 such such ADJ fnp-5195 130 17 biopsies biopsy NOUN fnp-5195 130 18 . . PUNCT fnp-5195 131 1 our our PRON fnp-5195 131 2 dataset dataset NOUN fnp-5195 131 3 is be AUX fnp-5195 131 4 comprised comprise VERB fnp-5195 131 5 of of ADP fnp-5195 131 6 72 72 NUM fnp-5195 131 7 temporal temporal ADJ fnp-5195 131 8 artery artery NOUN fnp-5195 131 9 biopsies biopsy NOUN fnp-5195 131 10 subjected subject VERB fnp-5195 131 11 to to ADP fnp-5195 131 12 a a DET fnp-5195 131 13 uniform uniform ADJ fnp-5195 131 14 re re NOUN fnp-5195 131 15 - - NOUN fnp-5195 131 16 examination examination NOUN fnp-5195 131 17 paired pair VERB fnp-5195 131 18 with with ADP fnp-5195 131 19 clinical clinical ADJ fnp-5195 131 20 data datum NOUN fnp-5195 131 21 including include VERB fnp-5195 131 22 demographics demographic NOUN fnp-5195 131 23 , , PUNCT fnp-5195 131 24 history history NOUN fnp-5195 131 25 , , PUNCT fnp-5195 131 26 physical physical ADJ fnp-5195 131 27 examination examination NOUN fnp-5195 131 28 , , PUNCT fnp-5195 131 29 and and CCONJ fnp-5195 131 30 laboratory laboratory NOUN fnp-5195 131 31 findings finding NOUN fnp-5195 131 32 . . PUNCT fnp-5195 132 1 documented document VERB fnp-5195 132 2 pathology pathology NOUN fnp-5195 132 3 variables variable NOUN fnp-5195 132 4 include include VERB fnp-5195 132 5 the the DET fnp-5195 132 6 presence presence NOUN fnp-5195 132 7 or or CCONJ fnp-5195 132 8 absence absence NOUN fnp-5195 132 9 of of ADP fnp-5195 132 10 ta ta ADP fnp-5195 132 11 , , PUNCT fnp-5195 132 12 angiitis angiitis ADV fnp-5195 132 13 of of ADP fnp-5195 132 14 vasa vasa PROPN fnp-5195 132 15 vasorum vasorum NOUN fnp-5195 132 16 ( ( PUNCT fnp-5195 132 17 avv avv PROPN fnp-5195 132 18 ) ) PUNCT fnp-5195 132 19 , , PUNCT fnp-5195 132 20 and and CCONJ fnp-5195 132 21 inflammation inflammation NOUN fnp-5195 132 22 of of ADP fnp-5195 132 23 small small ADJ fnp-5195 132 24 peri peri NOUN fnp-5195 132 25 - - PUNCT fnp-5195 132 26 adventitial adventitial ADJ fnp-5195 132 27 vessels vessel NOUN fnp-5195 132 28 consistent consistent ADJ fnp-5195 132 29 with with ADP fnp-5195 132 30 small small ADJ fnp-5195 132 31 vessel vessel NOUN fnp-5195 132 32 vasculitis vasculitis PROPN fnp-5195 132 33 ( ( PUNCT fnp-5195 132 34 svv svv ADJ fnp-5195 132 35 ) ) PUNCT fnp-5195 132 36 . . PUNCT fnp-5195 133 1 clinical clinical ADJ fnp-5195 133 2 and and CCONJ fnp-5195 133 3 pathological pathological ADJ fnp-5195 133 4 variables variable NOUN fnp-5195 133 5 were be AUX fnp-5195 133 6 subjected subject VERB fnp-5195 133 7 to to PART fnp-5195 133 8 multivariate multivariate VERB fnp-5195 133 9 analysis analysis NOUN fnp-5195 133 10 . . PUNCT fnp-5195 134 1 in in ADP fnp-5195 134 2 brief brief ADJ fnp-5195 134 3 , , PUNCT fnp-5195 134 4 25 25 NUM fnp-5195 134 5 % % NOUN fnp-5195 134 6 of of ADP fnp-5195 134 7 cases case NOUN fnp-5195 134 8 were be AUX fnp-5195 134 9 identified identify VERB fnp-5195 134 10 as as ADP fnp-5195 134 11 ta ta PROPN fnp-5195 134 12 , , PUNCT fnp-5195 134 13 21 21 NUM fnp-5195 134 14 % % NOUN fnp-5195 134 15 as as ADP fnp-5195 134 16 isolated isolated ADJ fnp-5195 134 17 avv avv NOUN fnp-5195 134 18 , , PUNCT fnp-5195 134 19 7 7 NUM fnp-5195 134 20 % % NOUN fnp-5195 134 21 as as ADP fnp-5195 134 22 isolated isolate VERB fnp-5195 134 23 svv svv VERB fnp-5195 134 24 , , PUNCT fnp-5195 134 25 and and CCONJ fnp-5195 134 26 5 5 NUM fnp-5195 134 27 % % NOUN fnp-5195 134 28 as as ADP fnp-5195 134 29 mixed mixed ADJ fnp-5195 134 30 avv avv NOUN fnp-5195 134 31 / / SYM fnp-5195 134 32 svv svv ADJ fnp-5195 134 33 , , PUNCT fnp-5195 134 34 while while SCONJ fnp-5195 134 35 42 42 NUM fnp-5195 134 36 % % NOUN fnp-5195 134 37 showed show VERB fnp-5195 134 38 no no DET fnp-5195 134 39 inflammation inflammation NOUN fnp-5195 134 40 . . PUNCT fnp-5195 135 1 all all DET fnp-5195 135 2 cases case NOUN fnp-5195 135 3 of of ADP fnp-5195 135 4 ta ta PROPN fnp-5195 135 5 were be AUX fnp-5195 135 6 accompanied accompany VERB fnp-5195 135 7 by by ADP fnp-5195 135 8 small small ADJ fnp-5195 135 9 vessel vessel NOUN fnp-5195 135 10 inflammation inflammation NOUN fnp-5195 135 11 : : PUNCT fnp-5195 135 12 94.4 94.4 NUM fnp-5195 135 13 % % NOUN fnp-5195 135 14 exhibiting exhibit VERB fnp-5195 135 15 avv avv NOUN fnp-5195 135 16 with with ADP fnp-5195 135 17 or or CCONJ fnp-5195 135 18 without without ADP fnp-5195 135 19 svv svv VERB fnp-5195 135 20 , , PUNCT fnp-5195 135 21 and and CCONJ fnp-5195 135 22 5.6 5.6 NUM fnp-5195 135 23 % % NOUN fnp-5195 135 24 exhibiting exhibit VERB fnp-5195 135 25 svv svv VERB fnp-5195 135 26 , , PUNCT fnp-5195 135 27 demonstrating demonstrate VERB fnp-5195 135 28 a a DET fnp-5195 135 29 strong strong ADJ fnp-5195 135 30 association association NOUN fnp-5195 135 31 between between ADP fnp-5195 135 32 ta ta PROPN fnp-5195 135 33 and and CCONJ fnp-5195 135 34 small small ADJ fnp-5195 135 35 vessel vessel NOUN fnp-5195 135 36 inflammation inflammation NOUN fnp-5195 135 37 . . PUNCT fnp-5195 136 1 of of ADP fnp-5195 136 2 the the DET fnp-5195 136 3 24 24 NUM fnp-5195 136 4 cases case NOUN fnp-5195 136 5 with with ADP fnp-5195 136 6 isolated isolated ADJ fnp-5195 136 7 avv avv NOUN fnp-5195 136 8 / / SYM fnp-5195 136 9 svv svv ADJ fnp-5195 136 10 , , PUNCT fnp-5195 136 11 25 25 NUM fnp-5195 136 12 % % NOUN fnp-5195 136 13 progressed progress VERB fnp-5195 136 14 to to ADP fnp-5195 136 15 a a DET fnp-5195 136 16 clinical clinical ADJ fnp-5195 136 17 diagnosis diagnosis NOUN fnp-5195 136 18 of of ADP fnp-5195 136 19 ta ta PROPN fnp-5195 136 20 within within ADP fnp-5195 136 21 one one NUM fnp-5195 136 22 year year NOUN fnp-5195 136 23 whereas whereas SCONJ fnp-5195 136 24 only only ADV fnp-5195 136 25 10 10 NUM fnp-5195 136 26 % % NOUN fnp-5195 136 27 of of ADP fnp-5195 136 28 cases case NOUN fnp-5195 136 29 with with ADP fnp-5195 136 30 no no DET fnp-5195 136 31 identifiable identifiable ADJ fnp-5195 136 32 inflammation inflammation NOUN fnp-5195 136 33 showed show VERB fnp-5195 136 34 such such ADJ fnp-5195 136 35 progression progression NOUN fnp-5195 136 36 . . PUNCT fnp-5195 137 1 furthermore furthermore ADV fnp-5195 137 2 , , PUNCT fnp-5195 137 3 isolated isolated ADJ fnp-5195 137 4 avv avv NOUN fnp-5195 137 5 / / SYM fnp-5195 137 6 svv svv VERB fnp-5195 137 7 was be AUX fnp-5195 137 8 identified identify VERB fnp-5195 137 9 in in ADP fnp-5195 137 10 25 25 NUM fnp-5195 137 11 % % NOUN fnp-5195 137 12 of of ADP fnp-5195 137 13 patients patient NOUN fnp-5195 137 14 with with ADP fnp-5195 137 15 a a DET fnp-5195 137 16 high high ADJ fnp-5195 137 17 clinical clinical ADJ fnp-5195 137 18 probability probability NOUN fnp-5195 137 19 for for ADP fnp-5195 137 20 ta ta PROPN fnp-5195 137 21 , , PUNCT fnp-5195 137 22 60 60 NUM fnp-5195 137 23 % % NOUN fnp-5195 137 24 of of ADP fnp-5195 137 25 whom whom PRON fnp-5195 137 26 acquired acquire VERB fnp-5195 137 27 a a DET fnp-5195 137 28 diagnosis diagnosis NOUN fnp-5195 137 29 of of ADP fnp-5195 137 30 ta ta PROPN fnp-5195 137 31 on on ADP fnp-5195 137 32 clinical clinical ADJ fnp-5195 137 33 grounds ground NOUN fnp-5195 137 34 within within ADP fnp-5195 137 35 one one NUM fnp-5195 137 36 year year NOUN fnp-5195 137 37 of of ADP fnp-5195 137 38 follow follow VERB fnp-5195 137 39 up up ADP fnp-5195 137 40 . . PUNCT fnp-5195 138 1 our our PRON fnp-5195 138 2 findings finding NOUN fnp-5195 138 3 suggest suggest VERB fnp-5195 138 4 that that SCONJ fnp-5195 138 5 isolated isolated ADJ fnp-5195 138 6 avv avv NOUN fnp-5195 138 7 / / SYM fnp-5195 138 8 svv svv PROPN fnp-5195 138 9 identifies identify VERB fnp-5195 138 10 a a DET fnp-5195 138 11 subgroup subgroup NOUN fnp-5195 138 12 of of ADP fnp-5195 138 13 patients patient NOUN fnp-5195 138 14 with with ADP fnp-5195 138 15 a a DET fnp-5195 138 16 higher high ADJ fnp-5195 138 17 risk risk NOUN fnp-5195 138 18 of of ADP fnp-5195 138 19 harboring harboring NOUN fnp-5195 138 20 or or CCONJ fnp-5195 138 21 developing develop VERB fnp-5195 138 22 ta ta PROPN fnp-5195 138 23 . . PUNCT fnp-5195 138 24     SPACE fnp-5195 138 25 abstract abstract ADJ fnp-5195 138 26 11 11 NUM fnp-5195 138 27 free free ADJ fnp-5195 138 28 neuropathol neuropathol NOUN fnp-5195 138 29 4:20:14 4:20:14 NUM fnp-5195 138 30 the the DET fnp-5195 138 31 international international ADJ fnp-5195 138 32 spinal spinal PROPN fnp-5195 138 33 cord cord NOUN fnp-5195 138 34 injury injury NOUN fnp-5195 138 35 biobank biobank PROPN fnp-5195 138 36 : : PUNCT fnp-5195 138 37 neuropathological neuropathological ADJ fnp-5195 138 38 contributions contribution NOUN fnp-5195 138 39 to to ADP fnp-5195 138 40 global global ADJ fnp-5195 138 41 translational translational ADJ fnp-5195 138 42 research research NOUN fnp-5195 138 43 in in ADP fnp-5195 138 44 traumatic traumatic ADJ fnp-5195 138 45 spinal spinal NOUN fnp-5195 138 46 cord cord NOUN fnp-5195 138 47 injury injury PROPN fnp-5195 138 48 veronica veronica PROPN fnp-5195 138 49 hirsch hirsch PROPN fnp-5195 138 50 - - PUNCT fnp-5195 138 51 reinshagen1,2 reinshagen1,2 PROPN fnp-5195 138 52 , , PUNCT fnp-5195 138 53 adam adam PROPN fnp-5195 138 54 velenosi2,3 velenosi2,3 PROPN fnp-5195 138 55 , , PUNCT fnp-5195 138 56 sarah sarah PROPN fnp-5195 138 57 r. r. PROPN fnp-5195 138 58 morris2,4 morris2,4 PROPN fnp-5195 138 59 , , PUNCT fnp-5195 138 60 kevin kevin PROPN fnp-5195 138 61 dong2,3 dong2,3 PROPN fnp-5195 138 62 , , PUNCT fnp-5195 138 63 pushwant pushwant ADJ fnp-5195 138 64 mattu1 mattu1 PROPN fnp-5195 138 65 , , PUNCT fnp-5195 138 66 zahra zahra PROPN fnp-5195 138 67 samadi samadi PROPN fnp-5195 138 68 - - PUNCT fnp-5195 138 69 bahrami2,3 bahrami2,3 PROPN fnp-5195 138 70 , , PUNCT fnp-5195 138 71 sureyah sureyah PROPN fnp-5195 138 72 nassimbwa2,3 nassimbwa2,3 PROPN fnp-5195 138 73 , , PUNCT fnp-5195 138 74 eslam eslam PROPN fnp-5195 138 75 abdelaziz abdelaziz PROPN fnp-5195 138 76 2,3 2,3 NUM fnp-5195 138 77 , , PUNCT fnp-5195 138 78 piotr piotr PROPN fnp-5195 138 79 kozlowski2,5 kozlowski2,5 PROPN fnp-5195 138 80 , , PUNCT fnp-5195 138 81 g. g. PROPN fnp-5195 138 82 r. r. PROPN fnp-5195 138 83 wayne wayne PROPN fnp-5195 138 84 moore1,2 moore1,2 PROPN fnp-5195 138 85 , , PUNCT fnp-5195 138 86 cornelia cornelia PROPN fnp-5195 138 87 laule1,2,4,5 laule1,2,4,5 PROPN fnp-5195 138 88 , , PUNCT fnp-5195 138 89 brian brian PROPN fnp-5195 138 90 k. k. PROPN fnp-5195 138 91 kwon2,6 kwon2,6 PROPN fnp-5195 138 92 1 1 NUM fnp-5195 138 93 department department NOUN fnp-5195 138 94 of of ADP fnp-5195 138 95 pathology pathology NOUN fnp-5195 138 96 and and CCONJ fnp-5195 138 97 laboratory laboratory NOUN fnp-5195 138 98 medicine medicine NOUN fnp-5195 138 99 , , PUNCT fnp-5195 138 100 university university NOUN fnp-5195 138 101 of of ADP fnp-5195 138 102 british british PROPN fnp-5195 138 103 columbia columbia PROPN fnp-5195 138 104 , , PUNCT fnp-5195 138 105 british british PROPN fnp-5195 138 106 columbia columbia PROPN fnp-5195 138 107 , , PUNCT fnp-5195 138 108 canada canada PROPN fnp-5195 138 109 2 2 NUM fnp-5195 138 110 international international ADJ fnp-5195 138 111 collaboration collaboration NOUN fnp-5195 138 112 on on ADP fnp-5195 138 113 repair repair NOUN fnp-5195 138 114 discoveries discovery NOUN fnp-5195 138 115 , , PUNCT fnp-5195 138 116 university university NOUN fnp-5195 138 117 of of ADP fnp-5195 138 118 british british PROPN fnp-5195 138 119 columbia columbia PROPN fnp-5195 138 120 , , PUNCT fnp-5195 138 121 british british PROPN fnp-5195 138 122 columbia columbia PROPN fnp-5195 138 123 , , PUNCT fnp-5195 138 124 canada canada PROPN fnp-5195 138 125 3 3 NUM fnp-5195 138 126 praxis praxi VERB fnp-5195 138 127 spinal spinal PROPN fnp-5195 138 128 cord cord PROPN fnp-5195 138 129 institute institute PROPN fnp-5195 138 130 , , PUNCT fnp-5195 138 131 british british PROPN fnp-5195 138 132 columbia columbia PROPN fnp-5195 138 133 , , PUNCT fnp-5195 138 134 canada canada PROPN fnp-5195 138 135 4 4 NUM fnp-5195 138 136 department department PROPN fnp-5195 138 137 of of ADP fnp-5195 138 138 physics physics PROPN fnp-5195 138 139 and and CCONJ fnp-5195 138 140 astronomy astronomy NOUN fnp-5195 138 141 , , PUNCT fnp-5195 138 142 university university PROPN fnp-5195 138 143 of of ADP fnp-5195 138 144 british british PROPN fnp-5195 138 145 columbia columbia PROPN fnp-5195 138 146 , , PUNCT fnp-5195 138 147 british british PROPN fnp-5195 138 148 columbia columbia PROPN fnp-5195 138 149 , , PUNCT fnp-5195 138 150 canada canada PROPN fnp-5195 138 151 5 5 NUM fnp-5195 138 152 department department NOUN fnp-5195 138 153 of of ADP fnp-5195 138 154 radiology radiology NOUN fnp-5195 138 155 , , PUNCT fnp-5195 138 156 university university NOUN fnp-5195 138 157 of of ADP fnp-5195 138 158 british british PROPN fnp-5195 138 159 columbia columbia PROPN fnp-5195 138 160 , , PUNCT fnp-5195 138 161 british british PROPN fnp-5195 138 162 columbia columbia PROPN fnp-5195 138 163 , , PUNCT fnp-5195 138 164 canada canada PROPN fnp-5195 138 165 6 6 NUM fnp-5195 138 166 department department NOUN fnp-5195 138 167 of of ADP fnp-5195 138 168 orthopedics orthopedic NOUN fnp-5195 138 169 , , PUNCT fnp-5195 138 170 university university NOUN fnp-5195 138 171 of of ADP fnp-5195 138 172 british british PROPN fnp-5195 138 173 columbia columbia PROPN fnp-5195 138 174 , , PUNCT fnp-5195 138 175 british british PROPN fnp-5195 138 176 columbia columbia PROPN fnp-5195 138 177 , , PUNCT fnp-5195 138 178 canada canada PROPN fnp-5195 138 179 much much ADJ fnp-5195 138 180 of of ADP fnp-5195 138 181 the the DET fnp-5195 138 182 scientific scientific ADJ fnp-5195 138 183 research research NOUN fnp-5195 138 184 dedicated dedicate VERB fnp-5195 138 185 to to ADP fnp-5195 138 186 traumatic traumatic ADJ fnp-5195 138 187 spinal spinal NOUN fnp-5195 138 188 cord cord NOUN fnp-5195 138 189 injury injury NOUN fnp-5195 138 190 ( ( PUNCT fnp-5195 138 191 tsci tsci NOUN fnp-5195 138 192 ) ) PUNCT fnp-5195 138 193 has have AUX fnp-5195 138 194 focused focus VERB fnp-5195 138 195 on on ADP fnp-5195 138 196 animal animal NOUN fnp-5195 138 197 models model NOUN fnp-5195 138 198 of of ADP fnp-5195 138 199 tsci tsci PROPN fnp-5195 138 200 . . PUNCT fnp-5195 139 1 our our PRON fnp-5195 139 2 understanding understanding NOUN fnp-5195 139 3 of of ADP fnp-5195 139 4 human human ADJ fnp-5195 139 5 tsci tsci PROPN fnp-5195 139 6 is be AUX fnp-5195 139 7 hampered hamper VERB fnp-5195 139 8 in in ADP fnp-5195 139 9 part part NOUN fnp-5195 139 10 by by ADP fnp-5195 139 11 lack lack NOUN fnp-5195 139 12 of of ADP fnp-5195 139 13 biospecimens biospecimen NOUN fnp-5195 139 14 from from ADP fnp-5195 139 15 patients patient NOUN fnp-5195 139 16 . . PUNCT fnp-5195 140 1 this this DET fnp-5195 140 2 gap gap NOUN fnp-5195 140 3 in in ADP fnp-5195 140 4 knowledge knowledge NOUN fnp-5195 140 5 represents represent VERB fnp-5195 140 6 an an DET fnp-5195 140 7 important important ADJ fnp-5195 140 8 void void NOUN fnp-5195 140 9 in in ADP fnp-5195 140 10 tsci tsci PROPN fnp-5195 140 11 translational translational ADJ fnp-5195 140 12 research research NOUN fnp-5195 140 13 , , PUNCT fnp-5195 140 14 as as SCONJ fnp-5195 140 15 biological biological ADJ fnp-5195 140 16 differences difference NOUN fnp-5195 140 17 between between ADP fnp-5195 140 18 animal animal NOUN fnp-5195 140 19 models model NOUN fnp-5195 140 20 and and CCONJ fnp-5195 140 21 the the DET fnp-5195 140 22 human human ADJ fnp-5195 140 23 condition condition NOUN fnp-5195 140 24 need need VERB fnp-5195 140 25 to to PART fnp-5195 140 26 be be AUX fnp-5195 140 27 considered consider VERB fnp-5195 140 28 in in ADP fnp-5195 140 29 the the DET fnp-5195 140 30 development development NOUN fnp-5195 140 31 of of ADP fnp-5195 140 32 therapeutic therapeutic ADJ fnp-5195 140 33 approaches approach NOUN fnp-5195 140 34 . . PUNCT fnp-5195 141 1 herein herein NOUN fnp-5195 141 2 we we PRON fnp-5195 141 3 introduce introduce VERB fnp-5195 141 4 the the DET fnp-5195 141 5 international international ADJ fnp-5195 141 6 spinal spinal NOUN fnp-5195 141 7 cord cord NOUN fnp-5195 141 8 injury injury PROPN fnp-5195 141 9 biobank biobank PROPN fnp-5195 141 10 ( ( PUNCT fnp-5195 141 11 iscib iscib PROPN fnp-5195 141 12 ; ; PUNCT fnp-5195 141 13 www.sci-biobank.org www.sci-biobank.org NOUN fnp-5195 141 14 ) ) PUNCT fnp-5195 141 15 , , PUNCT fnp-5195 141 16 a a DET fnp-5195 141 17 vancouver vancouver NOUN fnp-5195 141 18 - - PUNCT fnp-5195 141 19 based base VERB fnp-5195 141 20 , , PUNCT fnp-5195 141 21 multi multi ADJ fnp-5195 141 22 - - ADJ fnp-5195 141 23 user user ADJ fnp-5195 141 24 biorepository biorepository NOUN fnp-5195 141 25 with with ADP fnp-5195 141 26 global global ADJ fnp-5195 141 27 range range NOUN fnp-5195 141 28 and and CCONJ fnp-5195 141 29 the the DET fnp-5195 141 30 mission mission NOUN fnp-5195 141 31 of of ADP fnp-5195 141 32 accelerating accelerate VERB fnp-5195 141 33 therapeutic therapeutic ADJ fnp-5195 141 34 development development NOUN fnp-5195 141 35 in in ADP fnp-5195 141 36 sci sci PROPN fnp-5195 141 37 , , PUNCT fnp-5195 141 38 including include VERB fnp-5195 141 39 tsci tsci NOUN fnp-5195 141 40 , , PUNCT fnp-5195 141 41 through through ADP fnp-5195 141 42 improved improved ADJ fnp-5195 141 43 biological biological ADJ fnp-5195 141 44 understanding understanding NOUN fnp-5195 141 45 of of ADP fnp-5195 141 46 human human PROPN fnp-5195 141 47 sci sci PROPN fnp-5195 141 48 . . PROPN fnp-5195 141 49 certified certify VERB fnp-5195 141 50 by by ADP fnp-5195 141 51 the the DET fnp-5195 141 52 canadian canadian ADJ fnp-5195 141 53 tissue tissue NOUN fnp-5195 141 54 repository repository NOUN fnp-5195 141 55 network network NOUN fnp-5195 141 56 , , PUNCT fnp-5195 141 57 iscib iscib PROPN fnp-5195 141 58 will will AUX fnp-5195 141 59 be be AUX fnp-5195 141 60 introduced introduce VERB fnp-5195 141 61 to to ADP fnp-5195 141 62 the the DET fnp-5195 141 63 community community NOUN fnp-5195 141 64 of of ADP fnp-5195 141 65 canadian canadian ADJ fnp-5195 141 66 neuropathologists neuropathologist NOUN fnp-5195 141 67 as as ADP fnp-5195 141 68 a a DET fnp-5195 141 69 possible possible ADJ fnp-5195 141 70 resource resource NOUN fnp-5195 141 71 for for ADP fnp-5195 141 72 research research NOUN fnp-5195 141 73 or or CCONJ fnp-5195 141 74 post post ADJ fnp-5195 141 75 - - ADJ fnp-5195 141 76 mortem mortem ADJ fnp-5195 141 77 spinal spinal ADJ fnp-5195 141 78 cord cord NOUN fnp-5195 141 79 donation donation NOUN fnp-5195 141 80 . . PUNCT fnp-5195 142 1 we we PRON fnp-5195 142 2 describe describe VERB fnp-5195 142 3 the the DET fnp-5195 142 4 translational translational ADJ fnp-5195 142 5 research research NOUN fnp-5195 142 6 gap gap NOUN fnp-5195 142 7 that that PRON fnp-5195 142 8 iscib iscib PROPN fnp-5195 142 9 is be AUX fnp-5195 142 10 helping help VERB fnp-5195 142 11 to to PART fnp-5195 142 12 fill fill VERB fnp-5195 142 13 ; ; PUNCT fnp-5195 142 14 its its PRON fnp-5195 142 15 structure structure NOUN fnp-5195 142 16 , , PUNCT fnp-5195 142 17 governance governance NOUN fnp-5195 142 18 , , PUNCT fnp-5195 142 19 and and CCONJ fnp-5195 142 20 certification certification NOUN fnp-5195 142 21 ; ; PUNCT fnp-5195 142 22 how how SCONJ fnp-5195 142 23 data datum NOUN fnp-5195 142 24 and and CCONJ fnp-5195 142 25 samples sample NOUN fnp-5195 142 26 are be AUX fnp-5195 142 27 accrued accrue VERB fnp-5195 142 28 , , PUNCT fnp-5195 142 29 processed process VERB fnp-5195 142 30 and and CCONJ fnp-5195 142 31 stored store VERB fnp-5195 142 32 ; ; PUNCT fnp-5195 142 33 the the DET fnp-5195 142 34 process process NOUN fnp-5195 142 35 through through ADP fnp-5195 142 36 which which PRON fnp-5195 142 37 samples sample NOUN fnp-5195 142 38 and and CCONJ fnp-5195 142 39 data datum NOUN fnp-5195 142 40 are be AUX fnp-5195 142 41 shared share VERB fnp-5195 142 42 with with ADP fnp-5195 142 43 global global ADJ fnp-5195 142 44 researchers researcher NOUN fnp-5195 142 45 ; ; PUNCT fnp-5195 142 46 and and CCONJ fnp-5195 142 47 finally finally ADV fnp-5195 142 48 , , PUNCT fnp-5195 142 49 an an DET fnp-5195 142 50 example example NOUN fnp-5195 142 51 of of ADP fnp-5195 142 52 novel novel ADJ fnp-5195 142 53 clinicopathological clinicopathological ADJ fnp-5195 142 54 insights insight NOUN fnp-5195 142 55 we we PRON fnp-5195 142 56 are be AUX fnp-5195 142 57 gathering gather VERB fnp-5195 142 58 in in ADP fnp-5195 142 59 human human ADJ fnp-5195 142 60 tsci tsci PROPN fnp-5195 142 61 . . PUNCT fnp-5195 143 1 by by ADP fnp-5195 143 2 expanding expand VERB fnp-5195 143 3 awareness awareness NOUN fnp-5195 143 4 of of ADP fnp-5195 143 5 the the DET fnp-5195 143 6 existence existence NOUN fnp-5195 143 7 of of ADP fnp-5195 143 8 iscib iscib NOUN fnp-5195 143 9 within within ADP fnp-5195 143 10 the the DET fnp-5195 143 11 community community NOUN fnp-5195 143 12 of of ADP fnp-5195 143 13 canadian canadian ADJ fnp-5195 143 14 neuropathologists neuropathologist NOUN fnp-5195 143 15 , , PUNCT fnp-5195 143 16 we we PRON fnp-5195 143 17 hope hope VERB fnp-5195 143 18 to to PART fnp-5195 143 19 further further VERB fnp-5195 143 20 the the DET fnp-5195 143 21 mission mission NOUN fnp-5195 143 22 of of ADP fnp-5195 143 23 this this DET fnp-5195 143 24 pioneering pioneer VERB fnp-5195 143 25 world world NOUN fnp-5195 143 26 - - PUNCT fnp-5195 143 27 class class NOUN fnp-5195 143 28 sci sci PROPN fnp-5195 143 29 biorepository biorepository NOUN fnp-5195 143 30 . . PUNCT fnp-5195 143 31     SPACE fnp-5195 144 1 abstract abstract ADJ fnp-5195 144 2 12 12 NUM fnp-5195 144 3 free free ADJ fnp-5195 144 4 neuropathol neuropathol NOUN fnp-5195 144 5 4:20:15 4:20:15 NUM fnp-5195 144 6 death death NOUN fnp-5195 144 7 and and CCONJ fnp-5195 144 8 the the DET fnp-5195 144 9 maid maid NOUN fnp-5195 144 10 at at ADP fnp-5195 144 11 the the DET fnp-5195 144 12 calgary calgary PROPN fnp-5195 144 13 brain brain PROPN fnp-5195 144 14 bank bank PROPN fnp-5195 144 15 jeffrey jeffrey PROPN fnp-5195 144 16 t. t. PROPN fnp-5195 144 17 joseph1 joseph1 PROPN fnp-5195 144 18 1 1 NUM fnp-5195 144 19 department department NOUN fnp-5195 144 20 of of ADP fnp-5195 144 21 pathology pathology NOUN fnp-5195 144 22 and and CCONJ fnp-5195 144 23 laboratory laboratory NOUN fnp-5195 144 24 medicine medicine NOUN fnp-5195 144 25 , , PUNCT fnp-5195 144 26 university university NOUN fnp-5195 144 27 of of ADP fnp-5195 144 28 calgary calgary PROPN fnp-5195 144 29 , , PUNCT fnp-5195 144 30 calgary calgary PROPN fnp-5195 144 31 , , PUNCT fnp-5195 144 32 ab ab PROPN fnp-5195 144 33 , , PUNCT fnp-5195 144 34 canada canada PROPN fnp-5195 144 35 objective objective NOUN fnp-5195 144 36 : : PUNCT fnp-5195 144 37 determine determine VERB fnp-5195 144 38 tissue tissue NOUN fnp-5195 144 39 quality quality NOUN fnp-5195 144 40 parameters parameter NOUN fnp-5195 144 41 in in ADP fnp-5195 144 42 medical medical ADJ fnp-5195 144 43 assistance assistance NOUN fnp-5195 144 44 in in ADP fnp-5195 144 45 dying die VERB fnp-5195 144 46 ( ( PUNCT fnp-5195 144 47 maid maid NOUN fnp-5195 144 48 ) ) PUNCT fnp-5195 144 49 brain brain NOUN fnp-5195 144 50 donations donation NOUN fnp-5195 144 51 . . PUNCT fnp-5195 145 1 background background NOUN fnp-5195 145 2 : : PUNCT fnp-5195 145 3 in in ADP fnp-5195 145 4 canada canada PROPN fnp-5195 145 5 , , PUNCT fnp-5195 145 6 medical medical ADJ fnp-5195 145 7 assistance assistance NOUN fnp-5195 145 8 in in ADP fnp-5195 145 9 dying die VERB fnp-5195 145 10 ( ( PUNCT fnp-5195 145 11 maid maid PROPN fnp-5195 145 12 ) ) PUNCT fnp-5195 145 13 was be AUX fnp-5195 145 14 decriminalized decriminalize VERB fnp-5195 145 15 in in ADP fnp-5195 145 16 2015 2015 NUM fnp-5195 145 17 and and CCONJ fnp-5195 145 18 was be AUX fnp-5195 145 19 legalized legalize VERB fnp-5195 145 20 in in ADP fnp-5195 145 21 canada canada PROPN fnp-5195 145 22 and and CCONJ fnp-5195 145 23 alberta alberta PROPN fnp-5195 145 24 in in ADP fnp-5195 145 25 june june PROPN fnp-5195 145 26 2016 2016 NUM fnp-5195 145 27 . . PUNCT fnp-5195 146 1 methodology methodology NOUN fnp-5195 146 2 : : PUNCT fnp-5195 146 3 review review VERB fnp-5195 146 4 18 18 NUM fnp-5195 146 5 brain brain NOUN fnp-5195 146 6 donations donation NOUN fnp-5195 146 7 from from ADP fnp-5195 146 8 maid maid ADJ fnp-5195 146 9 patients patient NOUN fnp-5195 146 10 to to ADP fnp-5195 146 11 the the DET fnp-5195 146 12 cbb cbb NOUN fnp-5195 146 13 and and CCONJ fnp-5195 146 14 compare compare VERB fnp-5195 146 15 them they PRON fnp-5195 146 16 to to ADP fnp-5195 146 17 non non ADJ fnp-5195 146 18 - - ADJ fnp-5195 146 19 maid maid ADJ fnp-5195 146 20 donations donation NOUN fnp-5195 146 21 . . PUNCT fnp-5195 147 1 four four NUM fnp-5195 147 2 quality quality NOUN fnp-5195 147 3 parameters parameter NOUN fnp-5195 147 4 were be AUX fnp-5195 147 5 compared compare VERB fnp-5195 147 6 to to ADP fnp-5195 147 7 non non ADJ fnp-5195 147 8 - - ADJ fnp-5195 147 9 maid maid ADJ fnp-5195 147 10 patients patient NOUN fnp-5195 147 11 in in ADP fnp-5195 147 12 the the DET fnp-5195 147 13 cbb cbb NOUN fnp-5195 147 14 : : PUNCT fnp-5195 147 15 post post ADJ fnp-5195 147 16 - - ADJ fnp-5195 147 17 mortem mortem ADJ fnp-5195 147 18 interval interval NOUN fnp-5195 147 19 ( ( PUNCT fnp-5195 147 20 pmi pmi PROPN fnp-5195 147 21 ) ) PUNCT fnp-5195 147 22 , , PUNCT fnp-5195 147 23 neuronal neuronal ADJ fnp-5195 147 24 acidophilia acidophilia NOUN fnp-5195 147 25 ( ( PUNCT fnp-5195 147 26 surrogate surrogate ADJ fnp-5195 147 27 marker marker NOUN fnp-5195 147 28 for for ADP fnp-5195 147 29 hypoxia hypoxia NOUN fnp-5195 147 30 - - PUNCT fnp-5195 147 31 ischemia ischemia NOUN fnp-5195 147 32 ) ) PUNCT fnp-5195 147 33 , , PUNCT fnp-5195 147 34 type type NOUN fnp-5195 147 35 2 2 NUM fnp-5195 147 36 astrocytes astrocyte NOUN fnp-5195 147 37 in in ADP fnp-5195 147 38 the the DET fnp-5195 147 39 globus globus NOUN fnp-5195 147 40 pallidus pallidus PROPN fnp-5195 147 41 externus externus NOUN fnp-5195 147 42 ( ( PUNCT fnp-5195 147 43 surrogate surrogate ADJ fnp-5195 147 44 marker marker NOUN fnp-5195 147 45 for for ADP fnp-5195 147 46 systemic systemic ADJ fnp-5195 147 47 metabolic metabolic NOUN fnp-5195 147 48 derangements derangement NOUN fnp-5195 147 49 ) ) PUNCT fnp-5195 147 50 , , PUNCT fnp-5195 147 51 and and CCONJ fnp-5195 147 52 cerebellar cerebellar ADJ fnp-5195 147 53 internal internal ADJ fnp-5195 147 54 granular granular ADJ fnp-5195 147 55 neuron neuron NOUN fnp-5195 147 56 autolysis autolysis NOUN fnp-5195 147 57 ( ( PUNCT fnp-5195 147 58 reflection reflection NOUN fnp-5195 147 59 of of ADP fnp-5195 147 60 patient patient NOUN fnp-5195 147 61 's 's PART fnp-5195 147 62 pre pre ADJ fnp-5195 147 63 - - ADJ fnp-5195 147 64 mortem mortem ADJ fnp-5195 147 65 medical medical ADJ fnp-5195 147 66 state state NOUN fnp-5195 147 67 , , PUNCT fnp-5195 147 68 including include VERB fnp-5195 147 69 systemic systemic ADJ fnp-5195 147 70 acidosis acidosis NOUN fnp-5195 147 71 ) ) PUNCT fnp-5195 147 72 . . PUNCT fnp-5195 148 1 results result NOUN fnp-5195 148 2 : : PUNCT fnp-5195 148 3 two two NUM fnp-5195 148 4 procedural procedural ADJ fnp-5195 148 5 changes change NOUN fnp-5195 148 6 have have AUX fnp-5195 148 7 brought bring VERB fnp-5195 148 8 the the DET fnp-5195 148 9 pmi pmi NOUN fnp-5195 148 10 from from ADP fnp-5195 148 11 an an DET fnp-5195 148 12 average average NOUN fnp-5195 148 13 of of ADP fnp-5195 148 14 44 44 NUM fnp-5195 148 15 hours hour NOUN fnp-5195 148 16 to to ADP fnp-5195 148 17 6 6 NUM fnp-5195 148 18 hours hour NOUN fnp-5195 148 19 in in ADP fnp-5195 148 20 maid maid NOUN fnp-5195 148 21 patients patient NOUN fnp-5195 148 22 . . PUNCT fnp-5195 149 1 maid maid NOUN fnp-5195 149 2 patients patient NOUN fnp-5195 149 3 have have VERB fnp-5195 149 4 a a DET fnp-5195 149 5 significantly significantly ADV fnp-5195 149 6 shorter short ADJ fnp-5195 149 7 pmi pmi NOUN fnp-5195 149 8 than than ADP fnp-5195 149 9 non non ADJ fnp-5195 149 10 - - ADJ fnp-5195 149 11 maid maid ADJ fnp-5195 149 12 patients patient NOUN fnp-5195 149 13 . . PUNCT fnp-5195 150 1 unlike unlike ADP fnp-5195 150 2 many many ADJ fnp-5195 150 3 brain brain NOUN fnp-5195 150 4 bank bank NOUN fnp-5195 150 5 patients patient NOUN fnp-5195 150 6 , , PUNCT fnp-5195 150 7 who who PRON fnp-5195 150 8 die die VERB fnp-5195 150 9 from from ADP fnp-5195 150 10 non non ADJ fnp-5195 150 11 - - ADJ fnp-5195 150 12 neurological neurological ADJ fnp-5195 150 13 terminal terminal ADJ fnp-5195 150 14 diseases disease NOUN fnp-5195 150 15 , , PUNCT fnp-5195 150 16 most most ADJ fnp-5195 150 17 maid maid ADJ fnp-5195 150 18 patients patient NOUN fnp-5195 150 19 die die VERB fnp-5195 150 20 without without ADP fnp-5195 150 21 significant significant ADJ fnp-5195 150 22 systemic systemic ADJ fnp-5195 150 23 diseases disease NOUN fnp-5195 150 24 ; ; PUNCT fnp-5195 150 25 they they PRON fnp-5195 150 26 die die VERB fnp-5195 150 27 without without ADP fnp-5195 150 28 undergoing undergo VERB fnp-5195 150 29 prolonged prolonged ADJ fnp-5195 150 30 dying dying NOUN fnp-5195 150 31 . . PUNCT fnp-5195 151 1 maid maid ADJ fnp-5195 151 2 patient patient ADJ fnp-5195 151 3 brains brain NOUN fnp-5195 151 4 have have VERB fnp-5195 151 5 no no DET fnp-5195 151 6 or or CCONJ fnp-5195 151 7 only only ADV fnp-5195 151 8 early early ADJ fnp-5195 151 9 acidophilia acidophilia PROPN fnp-5195 151 10 in in ADP fnp-5195 151 11 sensitive sensitive ADJ fnp-5195 151 12 sites site NOUN fnp-5195 151 13 . . PUNCT fnp-5195 152 1 maid maid ADJ fnp-5195 152 2 patient patient ADJ fnp-5195 152 3 brains brain NOUN fnp-5195 152 4 have have VERB fnp-5195 152 5 no no DET fnp-5195 152 6 type type NOUN fnp-5195 152 7 2 2 NUM fnp-5195 152 8 astrocytes astrocyte NOUN fnp-5195 152 9 . . PUNCT fnp-5195 153 1 maid maid ADJ fnp-5195 153 2 patient patient ADJ fnp-5195 153 3 cerebellums cerebellum NOUN fnp-5195 153 4 lack lack VERB fnp-5195 153 5 internal internal ADJ fnp-5195 153 6 granular granular ADJ fnp-5195 153 7 neuron neuron NOUN fnp-5195 153 8 autolysis autolysis NOUN fnp-5195 153 9 . . PUNCT fnp-5195 154 1 conclusions conclusion NOUN fnp-5195 154 2 : : PUNCT fnp-5195 154 3 maid maid NOUN fnp-5195 154 4 patients patient NOUN fnp-5195 154 5 represent represent VERB fnp-5195 154 6 an an DET fnp-5195 154 7 important important ADJ fnp-5195 154 8 source source NOUN fnp-5195 154 9 of of ADP fnp-5195 154 10 autopsy autopsy ADJ fnp-5195 154 11 tissue tissue NOUN fnp-5195 154 12 , , PUNCT fnp-5195 154 13 which which PRON fnp-5195 154 14 circumvents circumvent VERB fnp-5195 154 15 degradation degradation NOUN fnp-5195 154 16 of of ADP fnp-5195 154 17 brain brain NOUN fnp-5195 154 18 tissue tissue NOUN fnp-5195 154 19 during during ADP fnp-5195 154 20 the the DET fnp-5195 154 21 dying die VERB fnp-5195 154 22 process process NOUN fnp-5195 154 23 that that PRON fnp-5195 154 24 affects affect VERB fnp-5195 154 25 many many ADJ fnp-5195 154 26 brain brain NOUN fnp-5195 154 27 banks bank NOUN fnp-5195 154 28 . . PUNCT fnp-5195 154 29     SPACE fnp-5195 155 1 abstract abstract ADJ fnp-5195 155 2 13 13 NUM fnp-5195 155 3 free free ADJ fnp-5195 155 4 neuropathol neuropathol NOUN fnp-5195 155 5 4:20:16 4:20:16 NUM fnp-5195 155 6 pathology pathology NOUN fnp-5195 155 7 of of ADP fnp-5195 155 8 the the DET fnp-5195 155 9 vertebral vertebral ADJ fnp-5195 155 10 artery artery NOUN fnp-5195 155 11 in in ADP fnp-5195 155 12 medicolegal medicolegal ADJ fnp-5195 155 13 autopsies autopsy NOUN fnp-5195 155 14 fabio fabio PROPN fnp-5195 155 15 a. a. PROPN fnp-5195 155 16 tironi1 tironi1 PROPN fnp-5195 155 17 , , PUNCT fnp-5195 155 18 sarathchandra sarathchandra NOUN fnp-5195 155 19 kodikara2 kodikara2 PROPN fnp-5195 155 20 , , PUNCT fnp-5195 155 21 michael michael PROPN fnp-5195 155 22 s. s. PROPN fnp-5195 155 23 pollanen1 pollanen1 PROPN fnp-5195 155 24 1 1 NUM fnp-5195 155 25 department department NOUN fnp-5195 155 26 of of ADP fnp-5195 155 27 laboratory laboratory NOUN fnp-5195 155 28 medicine medicine NOUN fnp-5195 155 29 and and CCONJ fnp-5195 155 30 pathobiology pathobiology NOUN fnp-5195 155 31 , , PUNCT fnp-5195 155 32 university university PROPN fnp-5195 155 33 of of ADP fnp-5195 155 34 toronto toronto PROPN fnp-5195 155 35 , , PUNCT fnp-5195 155 36 and and CCONJ fnp-5195 155 37 ontario ontario PROPN fnp-5195 155 38 forensic forensic ADJ fnp-5195 155 39 pathology pathology PROPN fnp-5195 155 40 service service PROPN fnp-5195 155 41 , , PUNCT fnp-5195 155 42 toronto toronto PROPN fnp-5195 155 43 , , PUNCT fnp-5195 155 44 on on ADP fnp-5195 155 45 , , PUNCT fnp-5195 155 46 canada canada PROPN fnp-5195 155 47 2 2 NUM fnp-5195 155 48 department department NOUN fnp-5195 155 49 of of ADP fnp-5195 155 50 forensic forensic ADJ fnp-5195 155 51 medicine medicine NOUN fnp-5195 155 52 , , PUNCT fnp-5195 155 53 university university NOUN fnp-5195 155 54 of of ADP fnp-5195 155 55 peradeniya peradeniya PROPN fnp-5195 155 56 , , PUNCT fnp-5195 155 57 kandy kandy PROPN fnp-5195 155 58 , , PUNCT fnp-5195 155 59 sri sri PROPN fnp-5195 155 60 lanka lanka PROPN fnp-5195 155 61 objective objective NOUN fnp-5195 155 62 : : PUNCT fnp-5195 155 63 describe describe VERB fnp-5195 155 64 the the DET fnp-5195 155 65 clinicopathologic clinicopathologic ADJ fnp-5195 155 66 features feature NOUN fnp-5195 155 67 of of ADP fnp-5195 155 68 the the DET fnp-5195 155 69 vertebral vertebral ADJ fnp-5195 155 70 artery artery NOUN fnp-5195 155 71 ( ( PUNCT fnp-5195 155 72 va va NOUN fnp-5195 155 73 ) ) PUNCT fnp-5195 155 74 in in ADP fnp-5195 155 75 medicolegal medicolegal ADJ fnp-5195 155 76 autopsies autopsy NOUN fnp-5195 155 77 . . PUNCT fnp-5195 156 1 methodology methodology NOUN fnp-5195 156 2 : : PUNCT fnp-5195 156 3 cases case NOUN fnp-5195 156 4 with with ADP fnp-5195 156 5 fatal fatal ADJ fnp-5195 156 6 or or CCONJ fnp-5195 156 7 significant significant ADJ fnp-5195 156 8 va va NOUN fnp-5195 156 9 pathology pathology NOUN fnp-5195 156 10 from from ADP fnp-5195 156 11 1996 1996 NUM fnp-5195 156 12 to to ADP fnp-5195 156 13 2011 2011 NUM fnp-5195 156 14 in in ADP fnp-5195 156 15 the the DET fnp-5195 156 16 provincial provincial ADJ fnp-5195 156 17 forensic forensic ADJ fnp-5195 156 18 pathology pathology NOUN fnp-5195 156 19 unit unit NOUN fnp-5195 156 20 , , PUNCT fnp-5195 156 21 toronto toronto PROPN fnp-5195 156 22 , , PUNCT fnp-5195 156 23 were be AUX fnp-5195 156 24 studied study VERB fnp-5195 156 25 . . PUNCT fnp-5195 157 1 reports report NOUN fnp-5195 157 2 and and CCONJ fnp-5195 157 3 histologic histologic NOUN fnp-5195 157 4 slides slide NOUN fnp-5195 157 5 were be AUX fnp-5195 157 6 reviewed review VERB fnp-5195 157 7 . . PUNCT fnp-5195 158 1 va va NOUN fnp-5195 158 2 examination examination NOUN fnp-5195 158 3 by by ADP fnp-5195 158 4 segment segment NOUN fnp-5195 158 5 and and CCONJ fnp-5195 158 6 pathological pathological ADJ fnp-5195 158 7 findings finding NOUN fnp-5195 158 8 were be AUX fnp-5195 158 9 analyzed analyze VERB fnp-5195 158 10 . . PUNCT fnp-5195 159 1 results result NOUN fnp-5195 159 2 : : PUNCT fnp-5195 159 3 twenty twenty NUM fnp-5195 159 4 - - PUNCT fnp-5195 159 5 six six NUM fnp-5195 159 6 cases case NOUN fnp-5195 159 7 were be AUX fnp-5195 159 8 included include VERB fnp-5195 159 9 , , PUNCT fnp-5195 159 10 2.7 2.7 NUM fnp-5195 159 11 male male NOUN fnp-5195 159 12 to to ADP fnp-5195 159 13 female female ADJ fnp-5195 159 14 ratio ratio NOUN fnp-5195 159 15 , , PUNCT fnp-5195 159 16 15 15 NUM fnp-5195 159 17 to to PART fnp-5195 159 18 76 76 NUM fnp-5195 159 19 years year NOUN fnp-5195 159 20 . . PUNCT fnp-5195 160 1 fourteen fourteen NUM fnp-5195 160 2 cases case NOUN fnp-5195 160 3 ( ( PUNCT fnp-5195 160 4 14/26 14/26 NUM fnp-5195 160 5 , , PUNCT fnp-5195 160 6 54 54 NUM fnp-5195 160 7 % % NOUN fnp-5195 160 8 ) ) PUNCT fnp-5195 160 9 were be AUX fnp-5195 160 10 trauma trauma NOUN fnp-5195 160 11 related relate VERB fnp-5195 160 12 , , PUNCT fnp-5195 160 13 11 11 NUM fnp-5195 160 14 cases case NOUN fnp-5195 160 15 ( ( PUNCT fnp-5195 160 16 11/26 11/26 NUM fnp-5195 160 17 , , PUNCT fnp-5195 160 18 42 42 NUM fnp-5195 160 19 % % NOUN fnp-5195 160 20 ) ) PUNCT fnp-5195 160 21 were be AUX fnp-5195 160 22 non non ADJ fnp-5195 160 23 - - ADJ fnp-5195 160 24 traumatic traumatic ADJ fnp-5195 160 25 , , PUNCT fnp-5195 160 26 and and CCONJ fnp-5195 160 27 1 1 NUM fnp-5195 160 28 overlap overlap NOUN fnp-5195 160 29 ( ( PUNCT fnp-5195 160 30 1/26 1/26 NUM fnp-5195 160 31 , , PUNCT fnp-5195 160 32 4 4 NUM fnp-5195 160 33 % % NOUN fnp-5195 160 34 ) ) PUNCT fnp-5195 160 35 . . PUNCT fnp-5195 161 1 the the DET fnp-5195 161 2 14 14 NUM fnp-5195 161 3 traumatic traumatic ADJ fnp-5195 161 4 cases case NOUN fnp-5195 161 5 had have VERB fnp-5195 161 6 mild mild ADJ fnp-5195 161 7 to to ADP fnp-5195 161 8 moderate moderate ADJ fnp-5195 161 9 external external ADJ fnp-5195 161 10 injuries injury NOUN fnp-5195 161 11 . . PUNCT fnp-5195 162 1 thirteen thirteen NUM fnp-5195 162 2 of of ADP fnp-5195 162 3 the the DET fnp-5195 162 4 14 14 NUM fnp-5195 162 5 trauma trauma NOUN fnp-5195 162 6 cases case NOUN fnp-5195 162 7 ( ( PUNCT fnp-5195 162 8 93 93 NUM fnp-5195 162 9 % % NOUN fnp-5195 162 10 ) ) PUNCT fnp-5195 162 11 had have VERB fnp-5195 162 12 a a DET fnp-5195 162 13 basal basal ADJ fnp-5195 162 14 subarachnoid subarachnoid NOUN fnp-5195 162 15 hemorrhage hemorrhage NOUN fnp-5195 162 16 ( ( PUNCT fnp-5195 162 17 sah sah PROPN fnp-5195 162 18 ) ) PUNCT fnp-5195 162 19 and and CCONJ fnp-5195 162 20 showed show VERB fnp-5195 162 21 transmural transmural ADJ fnp-5195 162 22 tears tear NOUN fnp-5195 162 23 in in ADP fnp-5195 162 24 the the DET fnp-5195 162 25 intracranial intracranial ADJ fnp-5195 162 26 ( ( PUNCT fnp-5195 162 27 v4 v4 NOUN fnp-5195 162 28 ) ) PUNCT fnp-5195 162 29 segment segment NOUN fnp-5195 162 30 . . PUNCT fnp-5195 163 1 the the DET fnp-5195 163 2 other other ADJ fnp-5195 163 3 trauma trauma NOUN fnp-5195 163 4 case case NOUN fnp-5195 163 5 had have VERB fnp-5195 163 6 dissection dissection NOUN fnp-5195 163 7 between between ADP fnp-5195 163 8 v1 v1 NOUN fnp-5195 163 9 and and CCONJ fnp-5195 163 10 v2 v2 NOUN fnp-5195 163 11 , , PUNCT fnp-5195 163 12 associated associate VERB fnp-5195 163 13 with with ADP fnp-5195 163 14 cerebellar cerebellar ADJ fnp-5195 163 15 , , PUNCT fnp-5195 163 16 brainstem brainstem NOUN fnp-5195 163 17 , , PUNCT fnp-5195 163 18 and and CCONJ fnp-5195 163 19 upper upper ADJ fnp-5195 163 20 spinal spinal NOUN fnp-5195 163 21 cord cord NOUN fnp-5195 163 22 ( ( PUNCT fnp-5195 163 23 cbsusc cbsusc NOUN fnp-5195 163 24 ) ) PUNCT fnp-5195 163 25 infarctions infarction NOUN fnp-5195 163 26 . . PUNCT fnp-5195 164 1 col3a1 col3a1 NOUN fnp-5195 164 2 mutations mutation NOUN fnp-5195 164 3 and and CCONJ fnp-5195 164 4 segmental segmental ADJ fnp-5195 164 5 mediolytic mediolytic ADJ fnp-5195 164 6 arteriopathy arteriopathy PROPN fnp-5195 164 7 ( ( PUNCT fnp-5195 164 8 sma sma PROPN fnp-5195 164 9 ) ) PUNCT fnp-5195 164 10 were be AUX fnp-5195 164 11 found find VERB fnp-5195 164 12 among among ADP fnp-5195 164 13 the the DET fnp-5195 164 14 cases case NOUN fnp-5195 164 15 . . PUNCT fnp-5195 165 1 the the DET fnp-5195 165 2 eleven eleven NUM fnp-5195 165 3 ( ( PUNCT fnp-5195 165 4 42 42 NUM fnp-5195 165 5 % % NOUN fnp-5195 165 6 ) ) PUNCT fnp-5195 165 7 non non ADJ fnp-5195 165 8 - - ADJ fnp-5195 165 9 traumatic traumatic ADJ fnp-5195 165 10 cases case NOUN fnp-5195 165 11 included include VERB fnp-5195 165 12 basal basal ADJ fnp-5195 165 13 sah sah PROPN fnp-5195 165 14 , , PUNCT fnp-5195 165 15 cbsusc cbsusc NOUN fnp-5195 165 16 and and CCONJ fnp-5195 165 17 thalamic thalamic ADJ fnp-5195 165 18 infarctions infarction NOUN fnp-5195 165 19 . . PUNCT fnp-5195 166 1 va va PROPN fnp-5195 166 2 thrombosis thrombosis NOUN fnp-5195 166 3 , , PUNCT fnp-5195 166 4 atherosclerosis atherosclerosis NOUN fnp-5195 166 5 , , PUNCT fnp-5195 166 6 dissection dissection NOUN fnp-5195 166 7 , , PUNCT fnp-5195 166 8 fibromuscular fibromuscular ADJ fnp-5195 166 9 dysplasia dysplasia NOUN fnp-5195 166 10 ( ( PUNCT fnp-5195 166 11 fmd fmd NOUN fnp-5195 166 12 ) ) PUNCT fnp-5195 166 13 , , PUNCT fnp-5195 166 14 sma sma VERB fnp-5195 166 15 and and CCONJ fnp-5195 166 16 col3a1 col3a1 NOUN fnp-5195 166 17 mutations mutation NOUN fnp-5195 166 18 were be AUX fnp-5195 166 19 present present ADJ fnp-5195 166 20 among among ADP fnp-5195 166 21 cases case NOUN fnp-5195 166 22 . . PUNCT fnp-5195 167 1 the the DET fnp-5195 167 2 overlap overlap NOUN fnp-5195 167 3 case case NOUN fnp-5195 167 4 presented present VERB fnp-5195 167 5 upper upper ADJ fnp-5195 167 6 posterior posterior ADJ fnp-5195 167 7 neck neck NOUN fnp-5195 167 8 trauma trauma NOUN fnp-5195 167 9 and and CCONJ fnp-5195 167 10 basal basal ADJ fnp-5195 167 11 sah sah NOUN fnp-5195 167 12 due due ADP fnp-5195 167 13 to to ADP fnp-5195 167 14 a a DET fnp-5195 167 15 v3 v3 PROPN fnp-5195 167 16 dissection dissection NOUN fnp-5195 167 17 . . PUNCT fnp-5195 168 1 in in ADP fnp-5195 168 2 this this DET fnp-5195 168 3 case case NOUN fnp-5195 168 4 , , PUNCT fnp-5195 168 5 there there PRON fnp-5195 168 6 was be VERB fnp-5195 168 7 also also ADV fnp-5195 168 8 fmd fmd NOUN fnp-5195 168 9 , , PUNCT fnp-5195 168 10 sma sma NOUN fnp-5195 168 11 , , PUNCT fnp-5195 168 12 multifocal multifocal ADJ fnp-5195 168 13 intramural intramural ADJ fnp-5195 168 14 hemorrhages hemorrhage NOUN fnp-5195 168 15 and and CCONJ fnp-5195 168 16 dissections dissection NOUN fnp-5195 168 17 involving involve VERB fnp-5195 168 18 craniocervical craniocervical ADJ fnp-5195 168 19 and and CCONJ fnp-5195 168 20 visceral visceral ADJ fnp-5195 168 21 arteries artery NOUN fnp-5195 168 22 and and CCONJ fnp-5195 168 23 a a DET fnp-5195 168 24 col3a1 col3a1 NOUN fnp-5195 168 25 mutation mutation NOUN fnp-5195 168 26 was be AUX fnp-5195 168 27 found find VERB fnp-5195 168 28 . . PUNCT fnp-5195 169 1 conclusion conclusion NOUN fnp-5195 169 2 : : PUNCT fnp-5195 169 3 traumatic traumatic ADJ fnp-5195 169 4 rupture rupture NOUN fnp-5195 169 5 of of ADP fnp-5195 169 6 v4 v4 PROPN fnp-5195 169 7 resulted result VERB fnp-5195 169 8 frequently frequently ADV fnp-5195 169 9 in in ADP fnp-5195 169 10 sah sah PROPN fnp-5195 169 11 . . PUNCT fnp-5195 170 1 non non ADJ fnp-5195 170 2 - - ADJ fnp-5195 170 3 traumatic traumatic ADJ fnp-5195 170 4 pathology pathology NOUN fnp-5195 170 5 predominately predominately ADV fnp-5195 170 6 occurs occur VERB fnp-5195 170 7 in in ADP fnp-5195 170 8 extracranial extracranial ADJ fnp-5195 170 9 va va NOUN fnp-5195 170 10 . . PUNCT fnp-5195 171 1 we we PRON fnp-5195 171 2 recommend recommend VERB fnp-5195 171 3 that that PRON fnp-5195 171 4 postmortem postmortem NOUN fnp-5195 171 5 examination examination NOUN fnp-5195 171 6 of of ADP fnp-5195 171 7 these these DET fnp-5195 171 8 cases case NOUN fnp-5195 171 9 includes include VERB fnp-5195 171 10 examination examination NOUN fnp-5195 171 11 or or CCONJ fnp-5195 171 12 the the DET fnp-5195 171 13 entire entire ADJ fnp-5195 171 14 vertebral vertebral ADJ fnp-5195 171 15 artery artery NOUN fnp-5195 171 16 . . PUNCT fnp-5195 171 17     SPACE fnp-5195 172 1 abstract abstract ADJ fnp-5195 172 2 14 14 NUM fnp-5195 172 3 free free ADJ fnp-5195 172 4 neuropathol neuropathol NOUN fnp-5195 172 5 4:20:17 4:20:17 NUM fnp-5195 172 6 study study NOUN fnp-5195 172 7 of of ADP fnp-5195 172 8 gamma gamma NOUN fnp-5195 172 9 - - PUNCT fnp-5195 172 10 aminobutyric aminobutyric ADJ fnp-5195 172 11 acid acid NOUN fnp-5195 172 12 and and CCONJ fnp-5195 172 13 glutamate glutamate VERB fnp-5195 172 14 signaling signal VERB fnp-5195 172 15 pathways pathway NOUN fnp-5195 172 16 in in ADP fnp-5195 172 17 glioblastoma glioblastoma NOUN fnp-5195 172 18 raul raul PROPN fnp-5195 172 19 cotau1,2,3,4 cotau1,2,3,4 PROPN fnp-5195 172 20 , , PUNCT fnp-5195 172 21 étienne étienne PROPN fnp-5195 172 22 audet audet PROPN fnp-5195 172 23 - - PUNCT fnp-5195 172 24 walsh1,4,5 walsh1,4,5 NOUN fnp-5195 172 25 , , PUNCT fnp-5195 172 26 maxime maxime NOUN fnp-5195 172 27 richer3,6 richer3,6 PROPN fnp-5195 172 28 1 1 NUM fnp-5195 172 29 department department NOUN fnp-5195 172 30 of of ADP fnp-5195 172 31 molecular molecular ADJ fnp-5195 172 32 medicine medicine NOUN fnp-5195 172 33 , , PUNCT fnp-5195 172 34 université université PROPN fnp-5195 172 35 laval laval PROPN fnp-5195 172 36 , , PUNCT fnp-5195 172 37 québec québec PROPN fnp-5195 172 38 , , PUNCT fnp-5195 172 39 canada canada PROPN fnp-5195 172 40 2 2 NUM fnp-5195 172 41 department department NOUN fnp-5195 172 42 of of ADP fnp-5195 172 43 medicine medicine NOUN fnp-5195 172 44 , , PUNCT fnp-5195 172 45 université université PROPN fnp-5195 172 46 laval laval PROPN fnp-5195 172 47 , , PUNCT fnp-5195 172 48 québec québec PROPN fnp-5195 172 49 , , PUNCT fnp-5195 172 50 canada canada PROPN fnp-5195 172 51 3 3 NUM fnp-5195 172 52 neuroscience neuroscience NOUN fnp-5195 172 53 axis axis NOUN fnp-5195 172 54 , , PUNCT fnp-5195 172 55 centre centre PROPN fnp-5195 172 56 de de X fnp-5195 172 57 recherche recherche X fnp-5195 172 58 du du PROPN fnp-5195 172 59 chu chu PROPN fnp-5195 172 60 de de X fnp-5195 172 61 québec québec PROPN fnp-5195 172 62 - - PUNCT fnp-5195 172 63 université université PROPN fnp-5195 172 64 laval laval PROPN fnp-5195 172 65 , , PUNCT fnp-5195 172 66 québec québec PROPN fnp-5195 172 67 , , PUNCT fnp-5195 172 68 canada canada PROPN fnp-5195 172 69 4 4 NUM fnp-5195 172 70 cancer cancer NOUN fnp-5195 172 71 research research NOUN fnp-5195 172 72 center center NOUN fnp-5195 172 73 , , PUNCT fnp-5195 172 74 université université PROPN fnp-5195 172 75 laval laval PROPN fnp-5195 172 76 , , PUNCT fnp-5195 172 77 québec québec PROPN fnp-5195 172 78 , , PUNCT fnp-5195 172 79 canada canada PROPN fnp-5195 172 80 5 5 NUM fnp-5195 172 81 endocrinology endocrinology NOUN fnp-5195 172 82 and and CCONJ fnp-5195 172 83 nephrology nephrology NOUN fnp-5195 172 84 axis axis NOUN fnp-5195 172 85 , , PUNCT fnp-5195 172 86 centre centre PROPN fnp-5195 172 87 de de X fnp-5195 172 88 recherche recherche X fnp-5195 172 89 du du PROPN fnp-5195 172 90 chu chu PROPN fnp-5195 172 91 de de X fnp-5195 172 92 québec québec PROPN fnp-5195 172 93 - - PUNCT fnp-5195 172 94 université université PROPN fnp-5195 172 95 laval laval PROPN fnp-5195 172 96 , , PUNCT fnp-5195 172 97 québec québec PROPN fnp-5195 172 98 , , PUNCT fnp-5195 172 99 canada canada PROPN fnp-5195 172 100 6 6 NUM fnp-5195 172 101 department department NOUN fnp-5195 172 102 of of ADP fnp-5195 172 103 molecular molecular ADJ fnp-5195 172 104 biology biology NOUN fnp-5195 172 105 , , PUNCT fnp-5195 172 106 medical medical ADJ fnp-5195 172 107 biochemistry biochemistry NOUN fnp-5195 172 108 , , PUNCT fnp-5195 172 109 and and CCONJ fnp-5195 172 110 pathology pathology NOUN fnp-5195 172 111 , , PUNCT fnp-5195 172 112 université université PROPN fnp-5195 172 113 laval laval PROPN fnp-5195 172 114 , , PUNCT fnp-5195 172 115 québec québec PROPN fnp-5195 172 116 , , PUNCT fnp-5195 172 117 canada canada PROPN fnp-5195 172 118 glioblastomas glioblastoma NOUN fnp-5195 172 119 ( ( PUNCT fnp-5195 172 120 gbm gbm PROPN fnp-5195 172 121 ) ) PUNCT fnp-5195 172 122 represent represent VERB fnp-5195 172 123 the the DET fnp-5195 172 124 majority majority NOUN fnp-5195 172 125 of of ADP fnp-5195 172 126 malignant malignant ADJ fnp-5195 172 127 primary primary ADJ fnp-5195 172 128 brain brain NOUN fnp-5195 172 129 tumors tumor NOUN fnp-5195 172 130 , , PUNCT fnp-5195 172 131 and and CCONJ fnp-5195 172 132 can can AUX fnp-5195 172 133 not not PART fnp-5195 172 134 be be AUX fnp-5195 172 135 cured cure VERB fnp-5195 172 136 . . PUNCT fnp-5195 173 1 the the DET fnp-5195 173 2 identification identification NOUN fnp-5195 173 3 of of ADP fnp-5195 173 4 their their PRON fnp-5195 173 5 survivaland survivaland NOUN fnp-5195 173 6 proliferation proliferation NOUN fnp-5195 173 7 - - PUNCT fnp-5195 173 8 associated associate VERB fnp-5195 173 9 mechanisms mechanism NOUN fnp-5195 173 10 may may AUX fnp-5195 173 11 help help VERB fnp-5195 173 12 introduce introduce VERB fnp-5195 173 13 new new ADJ fnp-5195 173 14 therapeutic therapeutic ADJ fnp-5195 173 15 targets target NOUN fnp-5195 173 16 . . PUNCT fnp-5195 174 1 several several ADJ fnp-5195 174 2 lines line NOUN fnp-5195 174 3 of of ADP fnp-5195 174 4 evidence evidence NOUN fnp-5195 174 5 suggest suggest VERB fnp-5195 174 6 that that SCONJ fnp-5195 174 7 neurotransmitters neurotransmitter NOUN fnp-5195 174 8 gamma gamma NOUN fnp-5195 174 9 - - PUNCT fnp-5195 174 10 aminobutyric aminobutyric ADJ fnp-5195 174 11 acid acid NOUN fnp-5195 174 12 ( ( PUNCT fnp-5195 174 13 gaba gaba PROPN fnp-5195 174 14 ) ) PUNCT fnp-5195 174 15 and and CCONJ fnp-5195 174 16 glutamate glutamate NOUN fnp-5195 174 17 are be AUX fnp-5195 174 18 involved involve VERB fnp-5195 174 19 in in ADP fnp-5195 174 20 gliomagenesis gliomagenesis NOUN fnp-5195 174 21 . . PUNCT fnp-5195 175 1 their their PRON fnp-5195 175 2 signaling signal VERB fnp-5195 175 3 pathways pathway NOUN fnp-5195 175 4 within within ADP fnp-5195 175 5 the the DET fnp-5195 175 6 tumor tumor NOUN fnp-5195 175 7 microenvironment microenvironment NOUN fnp-5195 175 8 ( ( PUNCT fnp-5195 175 9 tme tme NOUN fnp-5195 175 10 ) ) PUNCT fnp-5195 175 11 remain remain VERB fnp-5195 175 12 nonetheless nonetheless ADV fnp-5195 175 13 poorly poorly ADV fnp-5195 175 14 defined define VERB fnp-5195 175 15 . . PUNCT fnp-5195 176 1 we we PRON fnp-5195 176 2 hypothesize hypothesize VERB fnp-5195 176 3 that that SCONJ fnp-5195 176 4 the the DET fnp-5195 176 5 modulation modulation NOUN fnp-5195 176 6 of of ADP fnp-5195 176 7 gaba gaba PROPN fnp-5195 176 8 and and CCONJ fnp-5195 176 9 glutamate glutamate ADJ fnp-5195 176 10 genes gene NOUN fnp-5195 176 11 may may AUX fnp-5195 176 12 control control VERB fnp-5195 176 13 tumoral tumoral ADJ fnp-5195 176 14 aggressivity aggressivity NOUN fnp-5195 176 15 . . PUNCT fnp-5195 177 1 we we PRON fnp-5195 177 2 ( ( PUNCT fnp-5195 177 3 1 1 X fnp-5195 177 4 ) ) PUNCT fnp-5195 177 5 identify identify VERB fnp-5195 177 6 vulnerable vulnerable ADJ fnp-5195 177 7 biomarker biomarker NOUN fnp-5195 177 8 genes gene NOUN fnp-5195 177 9 for for ADP fnp-5195 177 10 gbm gbm NOUN fnp-5195 177 11 ( ( PUNCT fnp-5195 177 12 stage stage NOUN fnp-5195 177 13 iv iv NUM fnp-5195 177 14 glioma glioma NOUN fnp-5195 177 15 ) ) PUNCT fnp-5195 177 16 , , PUNCT fnp-5195 177 17 and and CCONJ fnp-5195 177 18 ( ( PUNCT fnp-5195 177 19 2 2 X fnp-5195 177 20 ) ) PUNCT fnp-5195 177 21 assess assess VERB fnp-5195 177 22 their their PRON fnp-5195 177 23 validity validity NOUN fnp-5195 177 24 in in ADP fnp-5195 177 25 in in ADP fnp-5195 177 26 vitro vitro X fnp-5195 177 27 and and CCONJ fnp-5195 177 28 clinical clinical ADJ fnp-5195 177 29 studies study NOUN fnp-5195 177 30 . . PUNCT fnp-5195 178 1 a a DET fnp-5195 178 2 gaba gaba NOUN fnp-5195 178 3 - - PUNCT fnp-5195 178 4 treated treat VERB fnp-5195 178 5 u87 u87 ADJ fnp-5195 178 6 gbm gbm PROPN fnp-5195 178 7 cell cell NOUN fnp-5195 178 8 line line NOUN fnp-5195 178 9 was be AUX fnp-5195 178 10 bulk bulk ADJ fnp-5195 178 11 rna rna NOUN fnp-5195 178 12 sequenced sequence VERB fnp-5195 178 13 , , PUNCT fnp-5195 178 14 and and CCONJ fnp-5195 178 15 single single ADJ fnp-5195 178 16 - - PUNCT fnp-5195 178 17 cell cell NOUN fnp-5195 178 18 rna rna NOUN fnp-5195 178 19 - - PUNCT fnp-5195 178 20 seq seq NOUN fnp-5195 178 21 data datum NOUN fnp-5195 178 22 of of ADP fnp-5195 178 23 9 9 NUM fnp-5195 178 24 resected resect VERB fnp-5195 178 25 new new ADJ fnp-5195 178 26 - - PUNCT fnp-5195 178 27 diagnostic diagnostic ADJ fnp-5195 178 28 , , PUNCT fnp-5195 178 29 and and CCONJ fnp-5195 178 30 5 5 NUM fnp-5195 178 31 recurrent recurrent ADJ fnp-5195 178 32 idh idh NOUN fnp-5195 178 33 - - PUNCT fnp-5195 178 34 wildtype wildtype NOUN fnp-5195 178 35 gbm gbm PROPN fnp-5195 178 36 allowed allow VERB fnp-5195 178 37 for for ADP fnp-5195 178 38 differential differential ADJ fnp-5195 178 39 and and CCONJ fnp-5195 178 40 enrichment enrichment NOUN fnp-5195 178 41 analysis analysis NOUN fnp-5195 178 42 . . PUNCT fnp-5195 179 1 data datum NOUN fnp-5195 179 2 suggested suggest VERB fnp-5195 179 3 that that SCONJ fnp-5195 179 4 gaba gaba PROPN fnp-5195 179 5 regulates regulate VERB fnp-5195 179 6 cancer cancer NOUN fnp-5195 179 7 - - PUNCT fnp-5195 179 8 associated associate VERB fnp-5195 179 9 pathways pathway NOUN fnp-5195 179 10 , , PUNCT fnp-5195 179 11 such such ADJ fnp-5195 179 12 as as ADP fnp-5195 179 13 survival survival NOUN fnp-5195 179 14 , , PUNCT fnp-5195 179 15 and and CCONJ fnp-5195 179 16 metabolism metabolism NOUN fnp-5195 179 17 . . PUNCT fnp-5195 180 1 using use VERB fnp-5195 180 2 a a DET fnp-5195 180 3 novel novel ADJ fnp-5195 180 4 algorithmic algorithmic ADJ fnp-5195 180 5 cell cell NOUN fnp-5195 180 6 type type NOUN fnp-5195 180 7 identification identification NOUN fnp-5195 180 8 approach approach NOUN fnp-5195 180 9 , , PUNCT fnp-5195 180 10 gbm gbm PROPN fnp-5195 180 11 cells cell NOUN fnp-5195 180 12 , , PUNCT fnp-5195 180 13 along along ADP fnp-5195 180 14 with with ADP fnp-5195 180 15 neuroimmune neuroimmune PROPN fnp-5195 180 16 proand proand PROPN fnp-5195 180 17 anti anti ADJ fnp-5195 180 18 - - ADJ fnp-5195 180 19 inflammatory inflammatory ADJ fnp-5195 180 20 populations population NOUN fnp-5195 180 21 were be AUX fnp-5195 180 22 identified identify VERB fnp-5195 180 23 . . PUNCT fnp-5195 181 1 potential potential ADJ fnp-5195 181 2 gaba gaba NOUN fnp-5195 181 3 , , PUNCT fnp-5195 181 4 glutamate glutamate NOUN fnp-5195 181 5 , , PUNCT fnp-5195 181 6 and and CCONJ fnp-5195 181 7 calcium calcium NOUN fnp-5195 181 8 neurotransmitter neurotransmitter NOUN fnp-5195 181 9 - - PUNCT fnp-5195 181 10 associated associate VERB fnp-5195 181 11 biomarkers biomarker NOUN fnp-5195 181 12 previously previously ADV fnp-5195 181 13 identified identify VERB fnp-5195 181 14 in in ADP fnp-5195 181 15 the the DET fnp-5195 181 16 laboratory laboratory NOUN fnp-5195 181 17 were be AUX fnp-5195 181 18 found find VERB fnp-5195 181 19 to to PART fnp-5195 181 20 be be AUX fnp-5195 181 21 differentially differentially ADV fnp-5195 181 22 expressed express VERB fnp-5195 181 23 between between ADP fnp-5195 181 24 cell cell NOUN fnp-5195 181 25 - - PUNCT fnp-5195 181 26 group group NOUN fnp-5195 181 27 clusters cluster NOUN fnp-5195 181 28 . . PUNCT fnp-5195 182 1 further further ADJ fnp-5195 182 2 enrichment enrichment NOUN fnp-5195 182 3 aims aim VERB fnp-5195 182 4 to to PART fnp-5195 182 5 identify identify VERB fnp-5195 182 6 cell cell NOUN fnp-5195 182 7 types type NOUN fnp-5195 182 8 , , PUNCT fnp-5195 182 9 and and CCONJ fnp-5195 182 10 genes gene NOUN fnp-5195 182 11 associated associate VERB fnp-5195 182 12 with with ADP fnp-5195 182 13 protumoral protumoral ADJ fnp-5195 182 14 activity activity NOUN fnp-5195 182 15 . . PUNCT fnp-5195 183 1 a a DET fnp-5195 183 2 cohort cohort NOUN fnp-5195 183 3 comprising comprise VERB fnp-5195 183 4 50 50 NUM fnp-5195 183 5 resected resect VERB fnp-5195 183 6 gbm gbm NOUN fnp-5195 183 7 samples sample NOUN fnp-5195 183 8 was be AUX fnp-5195 183 9 utilized utilize VERB fnp-5195 183 10 to to PART fnp-5195 183 11 associate associate VERB fnp-5195 183 12 those those DET fnp-5195 183 13 new new ADJ fnp-5195 183 14 genes gene NOUN fnp-5195 183 15 , , PUNCT fnp-5195 183 16 as as ADV fnp-5195 183 17 well well ADV fnp-5195 183 18 as as ADP fnp-5195 183 19 previous previous ADJ fnp-5195 183 20 markers marker NOUN fnp-5195 183 21 c5ar1 c5ar1 NOUN fnp-5195 183 22 , , PUNCT fnp-5195 183 23 vgat vgat NOUN fnp-5195 183 24 , , PUNCT fnp-5195 183 25 gad-1 gad-1 ADP fnp-5195 183 26 , , PUNCT fnp-5195 183 27 and and CCONJ fnp-5195 183 28 gaba gaba PROPN fnp-5195 183 29 - - PUNCT fnp-5195 183 30 b b NOUN fnp-5195 183 31 to to ADP fnp-5195 183 32 histologic histologic ADJ fnp-5195 183 33 characteristics characteristic NOUN fnp-5195 183 34 including include VERB fnp-5195 183 35 necrosis necrosis NOUN fnp-5195 183 36 , , PUNCT fnp-5195 183 37 angiogenesis angiogenesis NOUN fnp-5195 183 38 , , PUNCT fnp-5195 183 39 and and CCONJ fnp-5195 183 40 infiltration infiltration NOUN fnp-5195 183 41 . . PUNCT fnp-5195 184 1 immunohistochemical immunohistochemical ADJ fnp-5195 184 2 alignment alignment NOUN fnp-5195 184 3 between between ADP fnp-5195 184 4 our our PRON fnp-5195 184 5 , , PUNCT fnp-5195 184 6 and and CCONJ fnp-5195 184 7 clinical clinical ADJ fnp-5195 184 8 markers marker NOUN fnp-5195 184 9 ( ( PUNCT fnp-5195 184 10 ex ex NOUN fnp-5195 184 11 . . NOUN fnp-5195 184 12 mib1 mib1 NOUN fnp-5195 184 13 for for ADP fnp-5195 184 14 proliferation proliferation NOUN fnp-5195 184 15 ) ) PUNCT fnp-5195 184 16 was be AUX fnp-5195 184 17 performed perform VERB fnp-5195 184 18 . . PUNCT fnp-5195 185 1 gaba gaba PROPN fnp-5195 185 2 was be AUX fnp-5195 185 3 significantly significantly ADV fnp-5195 185 4 overexpressed overexpresse VERB fnp-5195 185 5 in in ADP fnp-5195 185 6 mib1 mib1 NOUN fnp-5195 185 7 - - PUNCT fnp-5195 185 8 rich rich ADJ fnp-5195 185 9 zones zone NOUN fnp-5195 185 10 . . PUNCT fnp-5195 186 1 this this DET fnp-5195 186 2 study study NOUN fnp-5195 186 3 introduces introduce VERB fnp-5195 186 4 gabaand gabaand NOUN fnp-5195 186 5 glutamate glutamate NOUN fnp-5195 186 6 - - PUNCT fnp-5195 186 7 associated associate VERB fnp-5195 186 8 biomarkers biomarker NOUN fnp-5195 186 9 as as ADP fnp-5195 186 10 potential potential ADJ fnp-5195 186 11 gbm gbm PROPN fnp-5195 186 12 therapeutic therapeutic ADJ fnp-5195 186 13 vulnerabilities vulnerability NOUN fnp-5195 186 14 . . PUNCT fnp-5195 186 15     SPACE fnp-5195 187 1 abstract abstract ADJ fnp-5195 187 2 15 15 NUM fnp-5195 187 3 free free ADJ fnp-5195 187 4 neuropathol neuropathol NOUN fnp-5195 187 5 4:20:18 4:20:18 NUM fnp-5195 187 6 using use VERB fnp-5195 187 7 molecular molecular ADJ fnp-5195 187 8 and and CCONJ fnp-5195 187 9 immunohistochemical immunohistochemical ADJ fnp-5195 187 10 features feature NOUN fnp-5195 187 11 to to PART fnp-5195 187 12 predict predict VERB fnp-5195 187 13 outcomes outcome NOUN fnp-5195 187 14 in in ADP fnp-5195 187 15 grade grade NOUN fnp-5195 187 16 3 3 NUM fnp-5195 187 17 meningiomas meningiomas PROPN fnp-5195 187 18 karina karina PROPN fnp-5195 187 19 chornenka chornenka PROPN fnp-5195 187 20 martin martin PROPN fnp-5195 187 21 , , PUNCT fnp-5195 187 22 md1 md1 PROPN fnp-5195 187 23 , , PUNCT fnp-5195 187 24 kira kira PROPN fnp-5195 187 25 tosefsky tosefsky PROPN fnp-5195 187 26 , , PUNCT fnp-5195 187 27 bsc2 bsc2 PROPN fnp-5195 187 28 , , PUNCT fnp-5195 187 29 alexander alexander PROPN fnp-5195 187 30 d. d. PROPN fnp-5195 187 31 rebchuk rebchuk PROPN fnp-5195 187 32 , , PUNCT fnp-5195 187 33 md md PROPN fnp-5195 187 34 msc2 msc2 PROPN fnp-5195 187 35 , , PUNCT fnp-5195 187 36 justin justin PROPN fnp-5195 187 37 z. z. PROPN fnp-5195 187 38 wang wang PROPN fnp-5195 187 39 , , PUNCT fnp-5195 187 40 md3,4,5 md3,4,5 NOUN fnp-5195 187 41 , , PUNCT fnp-5195 187 42 gelareh gelareh PROPN fnp-5195 187 43 zadeh zadeh PROPN fnp-5195 187 44 , , PUNCT fnp-5195 187 45 md md PROPN fnp-5195 187 46 phd3,4,5 phd3,4,5 PROPN fnp-5195 187 47 , , PUNCT fnp-5195 187 48 serge serge PROPN fnp-5195 187 49 makarenko makarenko PROPN fnp-5195 187 50 , , PUNCT fnp-5195 187 51 md2 md2 PROPN fnp-5195 187 52 , , PUNCT fnp-5195 187 53 stephen stephen PROPN fnp-5195 187 54 yip yip PROPN fnp-5195 187 55 , , PUNCT fnp-5195 187 56 md md PROPN fnp-5195 187 57 phd1 phd1 PROPN fnp-5195 187 58 1 1 NUM fnp-5195 187 59 department department PROPN fnp-5195 187 60 of of ADP fnp-5195 187 61 pathology pathology PROPN fnp-5195 187 62 & & CCONJ fnp-5195 187 63 laboratory laboratory PROPN fnp-5195 187 64 medicine medicine NOUN fnp-5195 187 65 , , PUNCT fnp-5195 187 66 faculty faculty NOUN fnp-5195 187 67 of of ADP fnp-5195 187 68 medicine medicine NOUN fnp-5195 187 69 , , PUNCT fnp-5195 187 70 university university NOUN fnp-5195 187 71 of of ADP fnp-5195 187 72 british british PROPN fnp-5195 187 73 columbia columbia PROPN fnp-5195 187 74 , , PUNCT fnp-5195 187 75 vancouver vancouver PROPN fnp-5195 187 76 , , PUNCT fnp-5195 187 77 british british PROPN fnp-5195 187 78 columbia columbia PROPN fnp-5195 187 79 , , PUNCT fnp-5195 187 80 canada canada PROPN fnp-5195 187 81 2 2 NUM fnp-5195 187 82 division division NOUN fnp-5195 187 83 of of ADP fnp-5195 187 84 neurosurgery neurosurgery NOUN fnp-5195 187 85 , , PUNCT fnp-5195 187 86 university university NOUN fnp-5195 187 87 of of ADP fnp-5195 187 88 british british PROPN fnp-5195 187 89 columbia columbia PROPN fnp-5195 187 90 , , PUNCT fnp-5195 187 91 vancouver vancouver PROPN fnp-5195 187 92 , , PUNCT fnp-5195 187 93 canada canada PROPN fnp-5195 187 94 3 3 NUM fnp-5195 187 95 division division NOUN fnp-5195 187 96 of of ADP fnp-5195 187 97 neurosurgery neurosurgery NOUN fnp-5195 187 98 , , PUNCT fnp-5195 187 99 university university PROPN fnp-5195 187 100 of of ADP fnp-5195 187 101 toronto toronto PROPN fnp-5195 187 102 , , PUNCT fnp-5195 187 103 toronto toronto PROPN fnp-5195 187 104 , , PUNCT fnp-5195 187 105 canada canada PROPN fnp-5195 187 106 4 4 NUM fnp-5195 187 107 macfeeters macfeeter NOUN fnp-5195 187 108 hamilton hamilton PROPN fnp-5195 187 109 neuro neuro PROPN fnp-5195 187 110 - - PUNCT fnp-5195 187 111 oncology oncology NOUN fnp-5195 187 112 program program NOUN fnp-5195 187 113 , , PUNCT fnp-5195 187 114 princess princess PROPN fnp-5195 187 115 margaret margaret PROPN fnp-5195 187 116 cancer cancer PROPN fnp-5195 187 117 centre centre PROPN fnp-5195 187 118 , , PUNCT fnp-5195 187 119 university university NOUN fnp-5195 187 120 health health NOUN fnp-5195 187 121 network network NOUN fnp-5195 187 122 and and CCONJ fnp-5195 187 123 university university PROPN fnp-5195 187 124 of of ADP fnp-5195 187 125 toronto toronto PROPN fnp-5195 187 126 , , PUNCT fnp-5195 187 127 toronto toronto PROPN fnp-5195 187 128 , , PUNCT fnp-5195 187 129 ontario ontario PROPN fnp-5195 187 130 , , PUNCT fnp-5195 187 131 canada canada PROPN fnp-5195 187 132 5 5 NUM fnp-5195 187 133 princess princess PROPN fnp-5195 187 134 margaret margaret PROPN fnp-5195 187 135 cancer cancer PROPN fnp-5195 187 136 centre centre PROPN fnp-5195 187 137 , , PUNCT fnp-5195 187 138 university university NOUN fnp-5195 187 139 health health NOUN fnp-5195 187 140 network network NOUN fnp-5195 187 141 , , PUNCT fnp-5195 187 142 toronto toronto PROPN fnp-5195 187 143 , , PUNCT fnp-5195 187 144 ontario ontario PROPN fnp-5195 187 145 , , PUNCT fnp-5195 187 146 canada canada PROPN fnp-5195 187 147 objective objective NOUN fnp-5195 187 148 : : PUNCT fnp-5195 187 149 the the DET fnp-5195 187 150 who who PRON fnp-5195 187 151 2021 2021 NUM fnp-5195 187 152 classification classification NOUN fnp-5195 187 153 introduces introduce VERB fnp-5195 187 154 molecular molecular ADJ fnp-5195 187 155 alterations alteration NOUN fnp-5195 187 156 in in ADP fnp-5195 187 157 meningiomas meningioma NOUN fnp-5195 187 158 that that PRON fnp-5195 187 159 are be AUX fnp-5195 187 160 associated associate VERB fnp-5195 187 161 with with ADP fnp-5195 187 162 increased increase VERB fnp-5195 187 163 risk risk NOUN fnp-5195 187 164 of of ADP fnp-5195 187 165 recurrence recurrence NOUN fnp-5195 187 166 and/or and/or CCONJ fnp-5195 187 167 shortened shorten VERB fnp-5195 187 168 overall overall ADJ fnp-5195 187 169 survival survival NOUN fnp-5195 187 170 ( ( PUNCT fnp-5195 187 171 os os NOUN fnp-5195 187 172 ) ) PUNCT fnp-5195 187 173 . . PUNCT fnp-5195 188 1 these these PRON fnp-5195 188 2 include include VERB fnp-5195 188 3 tert tert NOUN fnp-5195 188 4 promoter promoter NOUN fnp-5195 188 5 ( ( PUNCT fnp-5195 188 6 tertp tertp ADJ fnp-5195 188 7 ) ) PUNCT fnp-5195 188 8 mutations mutation NOUN fnp-5195 188 9 , , PUNCT fnp-5195 188 10 cdkn2a cdkn2a PROPN fnp-5195 188 11 / / SYM fnp-5195 188 12 b b NOUN fnp-5195 188 13 homozygous homozygous ADJ fnp-5195 188 14 deletion deletion NOUN fnp-5195 188 15 , , PUNCT fnp-5195 188 16 h3 h3 VERB fnp-5195 188 17 k27me3 k27me3 PROPN fnp-5195 188 18 loss loss NOUN fnp-5195 188 19 , , PUNCT fnp-5195 188 20 and and CCONJ fnp-5195 188 21 bap1 bap1 PROPN fnp-5195 188 22 loss loss NOUN fnp-5195 188 23 . . PUNCT fnp-5195 189 1 with with ADP fnp-5195 189 2 precise precise ADJ fnp-5195 189 3 prognostic prognostic ADJ fnp-5195 189 4 implications implication NOUN fnp-5195 189 5 pending pende VERB fnp-5195 189 6 further further ADJ fnp-5195 189 7 characterization characterization NOUN fnp-5195 189 8 , , PUNCT fnp-5195 189 9 we we PRON fnp-5195 189 10 explored explore VERB fnp-5195 189 11 these these DET fnp-5195 189 12 molecular molecular ADJ fnp-5195 189 13 alterations alteration NOUN fnp-5195 189 14 and and CCONJ fnp-5195 189 15 associated associate VERB fnp-5195 189 16 clinical clinical ADJ fnp-5195 189 17 outcomes outcome NOUN fnp-5195 189 18 in in ADP fnp-5195 189 19 a a DET fnp-5195 189 20 single single ADJ fnp-5195 189 21 - - PUNCT fnp-5195 189 22 center center NOUN fnp-5195 189 23 cohort cohort NOUN fnp-5195 189 24 of of ADP fnp-5195 189 25 grade grade NOUN fnp-5195 189 26 3 3 NUM fnp-5195 189 27 meningiomas meningioma NOUN fnp-5195 189 28 . . PUNCT fnp-5195 190 1 furthermore furthermore ADV fnp-5195 190 2 , , PUNCT fnp-5195 190 3 we we PRON fnp-5195 190 4 examined examine VERB fnp-5195 190 5 whether whether SCONJ fnp-5195 190 6 mtap mtap ADJ fnp-5195 190 7 and and CCONJ fnp-5195 190 8 p16 p16 NOUN fnp-5195 190 9 immunohistochemistry immunohistochemistry NOUN fnp-5195 190 10 can can AUX fnp-5195 190 11 predict predict VERB fnp-5195 190 12 cdkn2a cdkn2a PROPN fnp-5195 190 13 / / SYM fnp-5195 190 14 b b NOUN fnp-5195 190 15 status status NOUN fnp-5195 190 16 . . PUNCT fnp-5195 191 1 methods method NOUN fnp-5195 191 2 : : PUNCT fnp-5195 191 3 clinical clinical ADJ fnp-5195 191 4 and and CCONJ fnp-5195 191 5 histopathological histopathological ADJ fnp-5195 191 6 information information NOUN fnp-5195 191 7 were be AUX fnp-5195 191 8 obtained obtain VERB fnp-5195 191 9 from from ADP fnp-5195 191 10 the the DET fnp-5195 191 11 electronic electronic ADJ fnp-5195 191 12 medical medical ADJ fnp-5195 191 13 records record NOUN fnp-5195 191 14 of of ADP fnp-5195 191 15 grade grade NOUN fnp-5195 191 16 3 3 NUM fnp-5195 191 17 meningiomas meningioma NOUN fnp-5195 191 18 resected resect VERB fnp-5195 191 19 at at ADP fnp-5195 191 20 a a DET fnp-5195 191 21 tertiary tertiary ADJ fnp-5195 191 22 center center NOUN fnp-5195 191 23 between between ADP fnp-5195 191 24 2007 2007 NUM fnp-5195 191 25 - - SYM fnp-5195 191 26 2020 2020 NUM fnp-5195 191 27 . . PUNCT fnp-5195 192 1 molecular molecular ADJ fnp-5195 192 2 testing testing NOUN fnp-5195 192 3 for for ADP fnp-5195 192 4 tertp tertp ADJ fnp-5195 192 5 mutations mutation NOUN fnp-5195 192 6 and and CCONJ fnp-5195 192 7 cdkn2a cdkn2a PROPN fnp-5195 192 8 / / SYM fnp-5195 192 9 b b PROPN fnp-5195 192 10 status status NOUN fnp-5195 192 11 , , PUNCT fnp-5195 192 12 methylation methylation NOUN fnp-5195 192 13 profiling profiling NOUN fnp-5195 192 14 , , PUNCT fnp-5195 192 15 and and CCONJ fnp-5195 192 16 immunohistochemistry immunohistochemistry NOUN fnp-5195 192 17 for for ADP fnp-5195 192 18 h3 h3 PROPN fnp-5195 192 19 k27me3 k27me3 PROPN fnp-5195 192 20 , , PUNCT fnp-5195 192 21 bap1 bap1 PROPN fnp-5195 192 22 , , PUNCT fnp-5195 192 23 p16 p16 NOUN fnp-5195 192 24 , , PUNCT fnp-5195 192 25 and and CCONJ fnp-5195 192 26 mtap mtap ADJ fnp-5195 192 27 were be AUX fnp-5195 192 28 performed perform VERB fnp-5195 192 29 . . PUNCT fnp-5195 193 1 predictors predictor NOUN fnp-5195 193 2 of of ADP fnp-5195 193 3 survival survival NOUN fnp-5195 193 4 were be AUX fnp-5195 193 5 identified identify VERB fnp-5195 193 6 by by ADP fnp-5195 193 7 cox cox PROPN fnp-5195 193 8 regression regression PROPN fnp-5195 193 9 . . PUNCT fnp-5195 194 1 mtap mtap ADJ fnp-5195 194 2 and and CCONJ fnp-5195 194 3 p16 p16 NOUN fnp-5195 194 4 expression expression NOUN fnp-5195 194 5 were be AUX fnp-5195 194 6 assessed assess VERB fnp-5195 194 7 and and CCONJ fnp-5195 194 8 correlated correlate VERB fnp-5195 194 9 with with ADP fnp-5195 194 10 cdkn2a cdkn2a PROPN fnp-5195 194 11 / / SYM fnp-5195 194 12 b b PROPN fnp-5195 194 13 status status NOUN fnp-5195 194 14 . . PUNCT fnp-5195 195 1 results result NOUN fnp-5195 195 2 : : PUNCT fnp-5195 195 3 out out ADP fnp-5195 195 4 of of ADP fnp-5195 195 5 15 15 NUM fnp-5195 195 6 cases case NOUN fnp-5195 195 7 included include VERB fnp-5195 195 8 in in ADP fnp-5195 195 9 the the DET fnp-5195 195 10 study study NOUN fnp-5195 195 11 , , PUNCT fnp-5195 195 12 8/15 8/15 NUM fnp-5195 195 13 were be AUX fnp-5195 195 14 classified classify VERB fnp-5195 195 15 as as ADP fnp-5195 195 16 anaplastic anaplastic ADJ fnp-5195 195 17 , , PUNCT fnp-5195 195 18 6/15 6/15 NUM fnp-5195 195 19 as as ADP fnp-5195 195 20 rhabdoid rhabdoid NOUN fnp-5195 195 21 and and CCONJ fnp-5195 195 22 1/15 1/15 NUM fnp-5195 195 23 as as ADP fnp-5195 195 24 papillary papillary NOUN fnp-5195 195 25 . . PUNCT fnp-5195 196 1 one one NUM fnp-5195 196 2 rhabdoid rhabdoid NOUN fnp-5195 196 3 tumour tumour NOUN fnp-5195 196 4 exhibited exhibit VERB fnp-5195 196 5 bap1 bap1 PROPN fnp-5195 196 6 loss loss NOUN fnp-5195 196 7 , , PUNCT fnp-5195 196 8 four four NUM fnp-5195 196 9 tumours tumour NOUN fnp-5195 196 10 harboured harbour VERB fnp-5195 196 11 tertp tertp ADJ fnp-5195 196 12 mutations mutation NOUN fnp-5195 196 13 and and CCONJ fnp-5195 196 14 three three NUM fnp-5195 196 15 demonstrated demonstrate VERB fnp-5195 196 16 cdkn2a cdkn2a PROPN fnp-5195 196 17 / / SYM fnp-5195 196 18 b b NOUN fnp-5195 196 19 homozygous homozygous ADJ fnp-5195 196 20 deletion deletion NOUN fnp-5195 196 21 . . PUNCT fnp-5195 197 1 tertp tertp ADJ fnp-5195 197 2 mutations mutation NOUN fnp-5195 197 3 and and CCONJ fnp-5195 197 4 cdkn2a cdkn2a X fnp-5195 197 5 status status NOUN fnp-5195 197 6 were be AUX fnp-5195 197 7 associated associate VERB fnp-5195 197 8 with with ADP fnp-5195 197 9 significant significant ADJ fnp-5195 197 10 reductions reduction NOUN fnp-5195 197 11 in in ADP fnp-5195 197 12 os os NOUN fnp-5195 197 13 , , PUNCT fnp-5195 197 14 which which PRON fnp-5195 197 15 was be AUX fnp-5195 197 16 independent independent ADJ fnp-5195 197 17 of of ADP fnp-5195 197 18 simpson simpson PROPN fnp-5195 197 19 resection resection PROPN fnp-5195 197 20 grade grade NOUN fnp-5195 197 21 . . PUNCT fnp-5195 198 1 meningiomas meningioma NOUN fnp-5195 198 2 with with ADP fnp-5195 198 3 cdkn2a cdkn2a PROPN fnp-5195 198 4 / / SYM fnp-5195 198 5 b b NOUN fnp-5195 198 6 homozygous homozygous ADJ fnp-5195 198 7 deletion deletion NOUN fnp-5195 198 8 showed show VERB fnp-5195 198 9 consistent consistent ADJ fnp-5195 198 10 loss loss NOUN fnp-5195 198 11 of of ADP fnp-5195 198 12 p16 p16 NOUN fnp-5195 198 13 and and CCONJ fnp-5195 198 14 mtap mtap ADJ fnp-5195 198 15 immunoreactivity immunoreactivity NOUN fnp-5195 198 16 . . PUNCT fnp-5195 199 1 conclusion conclusion NOUN fnp-5195 199 2 : : PUNCT fnp-5195 199 3 tertp tertp ADJ fnp-5195 199 4 mutations mutation NOUN fnp-5195 199 5 and and CCONJ fnp-5195 199 6 cdkn2a cdkn2a PROPN fnp-5195 199 7 / / SYM fnp-5195 199 8 b b NOUN fnp-5195 199 9 homozygous homozygous ADJ fnp-5195 199 10 deletion deletion NOUN fnp-5195 199 11 are be AUX fnp-5195 199 12 significantly significantly ADV fnp-5195 199 13 associated associate VERB fnp-5195 199 14 with with ADP fnp-5195 199 15 reduced reduce VERB fnp-5195 199 16 os os PROPN fnp-5195 199 17 independent independent NOUN fnp-5195 199 18 of of ADP fnp-5195 199 19 resection resection NOUN fnp-5195 199 20 extent extent NOUN fnp-5195 199 21 . . PUNCT fnp-5195 200 1 our our PRON fnp-5195 200 2 findings finding NOUN fnp-5195 200 3 support support VERB fnp-5195 200 4 using use VERB fnp-5195 200 5 these these DET fnp-5195 200 6 molecular molecular ADJ fnp-5195 200 7 markers marker NOUN fnp-5195 200 8 for for ADP fnp-5195 200 9 prognostication prognostication NOUN fnp-5195 200 10 in in ADP fnp-5195 200 11 meningiomas meningioma NOUN fnp-5195 200 12 . . PUNCT fnp-5195 201 1 additionally additionally ADV fnp-5195 201 2 , , PUNCT fnp-5195 201 3 this this DET fnp-5195 201 4 small small ADJ fnp-5195 201 5 series series NOUN fnp-5195 201 6 demonstrates demonstrate VERB fnp-5195 201 7 that that SCONJ fnp-5195 201 8 p16 p16 NOUN fnp-5195 201 9 and and CCONJ fnp-5195 201 10 mtap mtap ADJ fnp-5195 201 11 immunohistochemistry immunohistochemistry NOUN fnp-5195 201 12 can can AUX fnp-5195 201 13 predict predict VERB fnp-5195 201 14 cdkn2a cdkn2a PROPN fnp-5195 201 15 / / SYM fnp-5195 201 16 b b NOUN fnp-5195 201 17 status status NOUN fnp-5195 201 18 . . PUNCT fnp-5195 201 19     SPACE fnp-5195 202 1 abstract abstract ADJ fnp-5195 202 2 16 16 NUM fnp-5195 202 3 free free ADJ fnp-5195 202 4 neuropathol neuropathol NOUN fnp-5195 202 5 4:20:19 4:20:19 NUM fnp-5195 202 6 pediatric pediatric ADJ fnp-5195 202 7 - - PUNCT fnp-5195 202 8 type type NOUN fnp-5195 202 9 gliomas glioma NOUN fnp-5195 202 10 in in ADP fnp-5195 202 11 adults adult NOUN fnp-5195 202 12 : : PUNCT fnp-5195 202 13 pathologic pathologic ADJ fnp-5195 202 14 and and CCONJ fnp-5195 202 15 molecular molecular ADJ fnp-5195 202 16 features feature NOUN fnp-5195 202 17 andrew andrew PROPN fnp-5195 202 18 f. f. PROPN fnp-5195 202 19 gao1 gao1 PROPN fnp-5195 202 20 , , PUNCT fnp-5195 202 21 josé josé PROPN fnp-5195 202 22 - - PUNCT fnp-5195 202 23 mario mario PROPN fnp-5195 202 24 capo capo PROPN fnp-5195 202 25 - - PUNCT fnp-5195 202 26 chichi2 chichi2 PROPN fnp-5195 202 27 , , PUNCT fnp-5195 202 28 adam adam PROPN fnp-5195 202 29 smith2 smith2 PROPN fnp-5195 202 30 , , PUNCT fnp-5195 202 31 gelareh gelareh PROPN fnp-5195 202 32 zadeh3 zadeh3 NOUN fnp-5195 202 33 , , PUNCT fnp-5195 202 34 lili lili PROPN fnp-5195 202 35 - - PUNCT fnp-5195 202 36 naz naz PROPN fnp-5195 202 37 hazrati4 hazrati4 PROPN fnp-5195 202 38 , , PUNCT fnp-5195 202 39 cynthia cynthia PROPN fnp-5195 202 40 hawkins4 hawkins4 PROPN fnp-5195 202 41 , , PUNCT fnp-5195 202 42 phedias phedia NOUN fnp-5195 202 43 diamandis1 diamandis1 NOUN fnp-5195 202 44 1 1 NUM fnp-5195 202 45 division division NOUN fnp-5195 202 46 of of ADP fnp-5195 202 47 anatomic anatomic ADJ fnp-5195 202 48 pathology pathology NOUN fnp-5195 202 49 , , PUNCT fnp-5195 202 50 laboratory laboratory NOUN fnp-5195 202 51 medicine medicine NOUN fnp-5195 202 52 program program NOUN fnp-5195 202 53 , , PUNCT fnp-5195 202 54 university university NOUN fnp-5195 202 55 health health NOUN fnp-5195 202 56 network network NOUN fnp-5195 202 57 , , PUNCT fnp-5195 202 58 toronto toronto PROPN fnp-5195 202 59 , , PUNCT fnp-5195 202 60 on on ADP fnp-5195 202 61 2 2 NUM fnp-5195 202 62 division division NOUN fnp-5195 202 63 of of ADP fnp-5195 202 64 clinical clinical ADJ fnp-5195 202 65 laboratory laboratory NOUN fnp-5195 202 66 genetics genetic NOUN fnp-5195 202 67 , , PUNCT fnp-5195 202 68 laboratory laboratory NOUN fnp-5195 202 69 medicine medicine NOUN fnp-5195 202 70 program program NOUN fnp-5195 202 71 , , PUNCT fnp-5195 202 72 university university NOUN fnp-5195 202 73 health health NOUN fnp-5195 202 74 network network NOUN fnp-5195 202 75 , , PUNCT fnp-5195 202 76 toronto toronto PROPN fnp-5195 202 77 , , PUNCT fnp-5195 202 78 on on ADP fnp-5195 202 79 3 3 NUM fnp-5195 202 80 division division NOUN fnp-5195 202 81 of of ADP fnp-5195 202 82 neurosurgery neurosurgery NOUN fnp-5195 202 83 , , PUNCT fnp-5195 202 84 krembil krembil PROPN fnp-5195 202 85 neuroscience neuroscience NOUN fnp-5195 202 86 program program NOUN fnp-5195 202 87 , , PUNCT fnp-5195 202 88 university university NOUN fnp-5195 202 89 health health NOUN fnp-5195 202 90 network network NOUN fnp-5195 202 91 , , PUNCT fnp-5195 202 92 toronto toronto PROPN fnp-5195 202 93 , , PUNCT fnp-5195 202 94 on on ADP fnp-5195 202 95 4 4 NUM fnp-5195 202 96 dept dept NOUN fnp-5195 202 97 . . PROPN fnp-5195 202 98 of of ADP fnp-5195 202 99 pediatric pediatric ADJ fnp-5195 202 100 laboratory laboratory NOUN fnp-5195 202 101 medicine medicine NOUN fnp-5195 202 102 , , PUNCT fnp-5195 202 103 hospital hospital NOUN fnp-5195 202 104 for for ADP fnp-5195 202 105 sick sick ADJ fnp-5195 202 106 children child NOUN fnp-5195 202 107 , , PUNCT fnp-5195 202 108 toronto toronto PROPN fnp-5195 202 109 , , PUNCT fnp-5195 202 110 on on ADP fnp-5195 202 111 the the DET fnp-5195 202 112 2021 2021 NUM fnp-5195 202 113 who who PRON fnp-5195 202 114 classification classification NOUN fnp-5195 202 115 of of ADP fnp-5195 202 116 cns cns PROPN fnp-5195 202 117 tumours tumours PROPN fnp-5195 202 118 recognizes recognize VERB fnp-5195 202 119 adultand adultand ADP fnp-5195 202 120 pediatric pediatric ADJ fnp-5195 202 121 - - PUNCT fnp-5195 202 122 type type NOUN fnp-5195 202 123 gliomas glioma NOUN fnp-5195 202 124 , , PUNCT fnp-5195 202 125 which which PRON fnp-5195 202 126 have have VERB fnp-5195 202 127 important important ADJ fnp-5195 202 128 clinical clinical ADJ fnp-5195 202 129 and and CCONJ fnp-5195 202 130 biological biological ADJ fnp-5195 202 131 differences difference NOUN fnp-5195 202 132 . . PUNCT fnp-5195 203 1 while while SCONJ fnp-5195 203 2 pediatric pediatric ADJ fnp-5195 203 3 - - PUNCT fnp-5195 203 4 type type NOUN fnp-5195 203 5 gliomas glioma NOUN fnp-5195 203 6 occur occur VERB fnp-5195 203 7 most most ADV fnp-5195 203 8 commonly commonly ADV fnp-5195 203 9 in in ADP fnp-5195 203 10 children child NOUN fnp-5195 203 11 , , PUNCT fnp-5195 203 12 their their PRON fnp-5195 203 13 frequency frequency NOUN fnp-5195 203 14 and and CCONJ fnp-5195 203 15 pathologic pathologic ADJ fnp-5195 203 16 and and CCONJ fnp-5195 203 17 molecular molecular ADJ fnp-5195 203 18 features feature NOUN fnp-5195 203 19 in in ADP fnp-5195 203 20 the the DET fnp-5195 203 21 general general ADJ fnp-5195 203 22 adult adult NOUN fnp-5195 203 23 population population NOUN fnp-5195 203 24 have have AUX fnp-5195 203 25 not not PART fnp-5195 203 26 been be AUX fnp-5195 203 27 well well ADV fnp-5195 203 28 studied study VERB fnp-5195 203 29 . . PUNCT fnp-5195 204 1 we we PRON fnp-5195 204 2 prospectively prospectively ADV fnp-5195 204 3 characterized characterize VERB fnp-5195 204 4 a a DET fnp-5195 204 5 single single ADJ fnp-5195 204 6 - - PUNCT fnp-5195 204 7 institution institution NOUN fnp-5195 204 8 cohort cohort NOUN fnp-5195 204 9 of of ADP fnp-5195 204 10 498 498 NUM fnp-5195 204 11 consecutive consecutive ADJ fnp-5195 204 12 gliomas glioma NOUN fnp-5195 204 13 ( ( PUNCT fnp-5195 204 14 diffuse diffuse NOUN fnp-5195 204 15 gliomas glioma NOUN fnp-5195 204 16 , , PUNCT fnp-5195 204 17 circumscribed circumscribed ADJ fnp-5195 204 18 gliomas glioma NOUN fnp-5195 204 19 , , PUNCT fnp-5195 204 20 and and CCONJ fnp-5195 204 21 glioneuronal glioneuronal ADJ fnp-5195 204 22 tumours tumour NOUN fnp-5195 204 23 ) ) PUNCT fnp-5195 204 24 using use VERB fnp-5195 204 25 immunohistochemistry immunohistochemistry NOUN fnp-5195 204 26 , , PUNCT fnp-5195 204 27 sanger sanger PROPN fnp-5195 204 28 sequencing sequencing NOUN fnp-5195 204 29 , , PUNCT fnp-5195 204 30 panel panel NOUN fnp-5195 204 31 - - PUNCT fnp-5195 204 32 based base VERB fnp-5195 204 33 ngs ng NOUN fnp-5195 204 34 , , PUNCT fnp-5195 204 35 fish fish NOUN fnp-5195 204 36 , , PUNCT fnp-5195 204 37 snp snp ADJ fnp-5195 204 38 array array NOUN fnp-5195 204 39 , , PUNCT fnp-5195 204 40 and/or and/or CCONJ fnp-5195 204 41 dna dna PROPN fnp-5195 204 42 methylation methylation NOUN fnp-5195 204 43 profiling profiling NOUN fnp-5195 204 44 . . PUNCT fnp-5195 205 1 of of ADP fnp-5195 205 2 490 490 NUM fnp-5195 205 3 cases case NOUN fnp-5195 205 4 that that PRON fnp-5195 205 5 could could AUX fnp-5195 205 6 be be AUX fnp-5195 205 7 evaluated evaluate VERB fnp-5195 205 8 ( ( PUNCT fnp-5195 205 9 median median ADJ fnp-5195 205 10 age age NOUN fnp-5195 205 11 58 58 NUM fnp-5195 205 12 , , PUNCT fnp-5195 205 13 range range VERB fnp-5195 205 14 18 18 NUM fnp-5195 205 15 - - SYM fnp-5195 205 16 91 91 NUM fnp-5195 205 17 ) ) PUNCT fnp-5195 205 18 , , PUNCT fnp-5195 205 19 pediatric pediatric ADJ fnp-5195 205 20 - - PUNCT fnp-5195 205 21 type type NOUN fnp-5195 205 22 alterations alteration NOUN fnp-5195 205 23 were be AUX fnp-5195 205 24 identified identify VERB fnp-5195 205 25 in in ADP fnp-5195 205 26 61 61 NUM fnp-5195 205 27 ( ( PUNCT fnp-5195 205 28 12 12 NUM fnp-5195 205 29 % % NOUN fnp-5195 205 30 , , PUNCT fnp-5195 205 31 median median ADJ fnp-5195 205 32 age age NOUN fnp-5195 205 33 34 34 NUM fnp-5195 205 34 , , PUNCT fnp-5195 205 35 range range VERB fnp-5195 205 36 18 18 NUM fnp-5195 205 37 - - SYM fnp-5195 205 38 73 73 NUM fnp-5195 205 39 ) ) PUNCT fnp-5195 205 40 . . PUNCT fnp-5195 206 1 excluding exclude VERB fnp-5195 206 2 patients patient NOUN fnp-5195 206 3 > > X fnp-5195 206 4 55yo 55yo NOUN fnp-5195 206 5 with with ADP fnp-5195 206 6 glioblastoma glioblastoma NOUN fnp-5195 206 7 ( ( PUNCT fnp-5195 206 8 for for ADP fnp-5195 206 9 whom whom PRON fnp-5195 206 10 no no DET fnp-5195 206 11 molecular molecular ADJ fnp-5195 206 12 testing testing NOUN fnp-5195 206 13 was be AUX fnp-5195 206 14 performed perform VERB fnp-5195 206 15 ; ; PUNCT fnp-5195 206 16 n=227 n=227 NUM fnp-5195 206 17 , , PUNCT fnp-5195 206 18 46 46 NUM fnp-5195 206 19 % % NOUN fnp-5195 206 20 ) ) PUNCT fnp-5195 206 21 , , PUNCT fnp-5195 206 22 pediatric pediatric ADJ fnp-5195 206 23 - - PUNCT fnp-5195 206 24 type type NOUN fnp-5195 206 25 alterations alteration NOUN fnp-5195 206 26 comprised comprise VERB fnp-5195 206 27 23 23 NUM fnp-5195 206 28 % % NOUN fnp-5195 206 29 of of ADP fnp-5195 206 30 the the DET fnp-5195 206 31 remaining remain VERB fnp-5195 206 32 cohort cohort NOUN fnp-5195 206 33 ( ( PUNCT fnp-5195 206 34 61/263 61/263 NUM fnp-5195 206 35 ) ) PUNCT fnp-5195 206 36 , , PUNCT fnp-5195 206 37 compared compare VERB fnp-5195 206 38 to to ADP fnp-5195 206 39 45 45 NUM fnp-5195 206 40 % % NOUN fnp-5195 206 41 for for ADP fnp-5195 206 42 idh idh NOUN fnp-5195 206 43 mutations mutation NOUN fnp-5195 206 44 , , PUNCT fnp-5195 206 45 and and CCONJ fnp-5195 206 46 32 32 NUM fnp-5195 206 47 % % NOUN fnp-5195 206 48 for for ADP fnp-5195 206 49 adult adult NOUN fnp-5195 206 50 - - PUNCT fnp-5195 206 51 type type NOUN fnp-5195 206 52 gbm gbm NOUN fnp-5195 206 53 . . PUNCT fnp-5195 207 1 the the DET fnp-5195 207 2 frequency frequency NOUN fnp-5195 207 3 of of ADP fnp-5195 207 4 pediatric pediatric ADJ fnp-5195 207 5 - - PUNCT fnp-5195 207 6 type type NOUN fnp-5195 207 7 alterations alteration NOUN fnp-5195 207 8 exceeded exceed VERB fnp-5195 207 9 that that PRON fnp-5195 207 10 of of ADP fnp-5195 207 11 non non ADJ fnp-5195 207 12 - - ADJ fnp-5195 207 13 canonical canonical ADJ fnp-5195 207 14 idh idh NOUN fnp-5195 207 15 mutations mutation NOUN fnp-5195 207 16 in in ADP fnp-5195 207 17 histologic histologic ADJ fnp-5195 207 18 gbms gbms NOUN fnp-5195 207 19 ≤55yo ≤55yo NOUN fnp-5195 207 20 ( ( PUNCT fnp-5195 207 21 8 8 NUM fnp-5195 207 22 % % NOUN fnp-5195 207 23 vs vs ADP fnp-5195 207 24 3 3 NUM fnp-5195 207 25 % % NOUN fnp-5195 207 26 , , PUNCT fnp-5195 207 27 n=96 n=96 PROPN fnp-5195 207 28 ) ) PUNCT fnp-5195 207 29 , , PUNCT fnp-5195 207 30 and and CCONJ fnp-5195 207 31 exceeded exceed VERB fnp-5195 207 32 both both DET fnp-5195 207 33 non non ADJ fnp-5195 207 34 - - ADJ fnp-5195 207 35 canonical canonical ADJ fnp-5195 207 36 idh idh NOUN fnp-5195 207 37 mutations mutation NOUN fnp-5195 207 38 and and CCONJ fnp-5195 207 39 adult adult NOUN fnp-5195 207 40 - - PUNCT fnp-5195 207 41 type type NOUN fnp-5195 207 42 gbm gbm NOUN fnp-5195 207 43 in in ADP fnp-5195 207 44 tumours tumour NOUN fnp-5195 207 45 with with ADP fnp-5195 207 46 diffuse diffuse NOUN fnp-5195 207 47 lower low ADJ fnp-5195 207 48 - - PUNCT fnp-5195 207 49 grade grade NOUN fnp-5195 207 50 histology histology NOUN fnp-5195 207 51 ( ( PUNCT fnp-5195 207 52 20 20 NUM fnp-5195 207 53 % % NOUN fnp-5195 207 54 vs vs ADP fnp-5195 207 55 8 8 NUM fnp-5195 207 56 % % NOUN fnp-5195 207 57 and and CCONJ fnp-5195 207 58 17 17 NUM fnp-5195 207 59 % % NOUN fnp-5195 207 60 , , PUNCT fnp-5195 207 61 respectively respectively ADV fnp-5195 207 62 , , PUNCT fnp-5195 207 63 n=138 n=138 PROPN fnp-5195 207 64 ) ) PUNCT fnp-5195 207 65 . . PUNCT fnp-5195 208 1 h3 h3 NOUN fnp-5195 208 2 - - PUNCT fnp-5195 208 3 3a 3a NUM fnp-5195 208 4 , , PUNCT fnp-5195 208 5 braf braf NOUN fnp-5195 208 6 , , PUNCT fnp-5195 208 7 nf1 nf1 NOUN fnp-5195 208 8 , , PUNCT fnp-5195 208 9 and and CCONJ fnp-5195 208 10 mismatch mismatch ADJ fnp-5195 208 11 repair repair NOUN fnp-5195 208 12 were be AUX fnp-5195 208 13 the the DET fnp-5195 208 14 most most ADV fnp-5195 208 15 commonly commonly ADV fnp-5195 208 16 altered alter VERB fnp-5195 208 17 genes gene NOUN fnp-5195 208 18 in in ADP fnp-5195 208 19 pediatric pediatric ADJ fnp-5195 208 20 - - PUNCT fnp-5195 208 21 type type NOUN fnp-5195 208 22 diffuse diffuse NOUN fnp-5195 208 23 high high ADJ fnp-5195 208 24 - - PUNCT fnp-5195 208 25 grade grade NOUN fnp-5195 208 26 gliomas glioma NOUN fnp-5195 208 27 , , PUNCT fnp-5195 208 28 while while SCONJ fnp-5195 208 29 braf braf NOUN fnp-5195 208 30 , , PUNCT fnp-5195 208 31 fgfr1 fgfr1 NOUN fnp-5195 208 32 , , PUNCT fnp-5195 208 33 and and CCONJ fnp-5195 208 34 fgfr2 fgfr2 ADJ fnp-5195 208 35 alterations alteration NOUN fnp-5195 208 36 prevailed prevail VERB fnp-5195 208 37 in in ADP fnp-5195 208 38 diffuse diffuse ADJ fnp-5195 208 39 low low ADJ fnp-5195 208 40 - - PUNCT fnp-5195 208 41 grade grade NOUN fnp-5195 208 42 gliomas glioma NOUN fnp-5195 208 43 , , PUNCT fnp-5195 208 44 circumscribed circumscribed ADJ fnp-5195 208 45 gliomas glioma NOUN fnp-5195 208 46 , , PUNCT fnp-5195 208 47 and and CCONJ fnp-5195 208 48 glioneuronal glioneuronal ADJ fnp-5195 208 49 tumours tumour NOUN fnp-5195 208 50 . . PUNCT fnp-5195 209 1 in in ADP fnp-5195 209 2 our our PRON fnp-5195 209 3 cohort cohort NOUN fnp-5195 209 4 of of ADP fnp-5195 209 5 adult adult NOUN fnp-5195 209 6 patients patient NOUN fnp-5195 209 7 , , PUNCT fnp-5195 209 8 pediatric pediatric ADJ fnp-5195 209 9 - - PUNCT fnp-5195 209 10 type type NOUN fnp-5195 209 11 alterations alteration NOUN fnp-5195 209 12 are be AUX fnp-5195 209 13 relatively relatively ADV fnp-5195 209 14 common common ADJ fnp-5195 209 15 , , PUNCT fnp-5195 209 16 especially especially ADV fnp-5195 209 17 in in ADP fnp-5195 209 18 younger young ADJ fnp-5195 209 19 adults adult NOUN fnp-5195 209 20 and and CCONJ fnp-5195 209 21 lower low ADJ fnp-5195 209 22 - - PUNCT fnp-5195 209 23 grade grade NOUN fnp-5195 209 24 tumours tumour NOUN fnp-5195 209 25 . . PUNCT fnp-5195 210 1 pediatric pediatric ADJ fnp-5195 210 2 - - PUNCT fnp-5195 210 3 type type NOUN fnp-5195 210 4 alterations alteration NOUN fnp-5195 210 5 should should AUX fnp-5195 210 6 be be AUX fnp-5195 210 7 routinely routinely ADV fnp-5195 210 8 included include VERB fnp-5195 210 9 in in ADP fnp-5195 210 10 the the DET fnp-5195 210 11 diagnostic diagnostic ADJ fnp-5195 210 12 evaluation evaluation NOUN fnp-5195 210 13 and and CCONJ fnp-5195 210 14 molecular molecular ADJ fnp-5195 210 15 testing testing NOUN fnp-5195 210 16 of of ADP fnp-5195 210 17 gliomas glioma NOUN fnp-5195 210 18 in in ADP fnp-5195 210 19 adults adult NOUN fnp-5195 210 20 . . PUNCT fnp-5195 210 21     SPACE fnp-5195 211 1 abstract abstract ADJ fnp-5195 211 2 17 17 NUM fnp-5195 211 3 free free ADJ fnp-5195 211 4 neuropathol neuropathol NOUN fnp-5195 211 5 4:20:20 4:20:20 NUM fnp-5195 211 6 extra extra ADJ fnp-5195 211 7 - - ADJ fnp-5195 211 8 pineal pineal ADJ fnp-5195 211 9 papillary papillary ADJ fnp-5195 211 10 tumor tumor NOUN fnp-5195 211 11 of of ADP fnp-5195 211 12 the the DET fnp-5195 211 13 pineal pineal NOUN fnp-5195 211 14 region region NOUN fnp-5195 211 15 ( ( PUNCT fnp-5195 211 16 ptpr ptpr PROPN fnp-5195 211 17 ) ) PUNCT fnp-5195 211 18 masquarading masquarading NOUN fnp-5195 211 19 as as ADP fnp-5195 211 20 a a DET fnp-5195 211 21 subependymal subependymal ADJ fnp-5195 211 22 giant giant ADJ fnp-5195 211 23 cell cell NOUN fnp-5195 211 24 tumor tumor NOUN fnp-5195 211 25 ( ( PUNCT fnp-5195 211 26 sega sega NOUN fnp-5195 211 27 ) ) PUNCT fnp-5195 211 28 kenrick kenrick PROPN fnp-5195 211 29 wysong wysong PROPN fnp-5195 211 30 md1 md1 PROPN fnp-5195 211 31 , , PUNCT fnp-5195 211 32 matija matija NOUN fnp-5195 211 33 snuderl snuderl PROPN fnp-5195 211 34 md md PROPN fnp-5195 211 35 phd2 phd2 PROPN fnp-5195 211 36 , , PUNCT fnp-5195 211 37 john john PROPN fnp-5195 211 38 c. c. PROPN fnp-5195 211 39 dewitt dewitt PROPN fnp-5195 211 40 md md PROPN fnp-5195 211 41 phd1 phd1 PROPN fnp-5195 211 42 1 1 NUM fnp-5195 211 43 department department NOUN fnp-5195 211 44 of of ADP fnp-5195 211 45 pathology pathology NOUN fnp-5195 211 46 and and CCONJ fnp-5195 211 47 laboratory laboratory NOUN fnp-5195 211 48 medicine medicine NOUN fnp-5195 211 49 , , PUNCT fnp-5195 211 50 university university NOUN fnp-5195 211 51 of of ADP fnp-5195 211 52 vermont vermont PROPN fnp-5195 211 53 , , PUNCT fnp-5195 211 54 medical medical ADJ fnp-5195 211 55 center center NOUN fnp-5195 211 56 , , PUNCT fnp-5195 211 57 burlington burlington PROPN fnp-5195 211 58 , , PUNCT fnp-5195 211 59 vt vt PROPN fnp-5195 211 60 , , PUNCT fnp-5195 211 61 usa usa PROPN fnp-5195 211 62 2 2 NUM fnp-5195 211 63 department department NOUN fnp-5195 211 64 of of ADP fnp-5195 211 65 pathology pathology PROPN fnp-5195 211 66 , , PUNCT fnp-5195 211 67 nyu nyu PROPN fnp-5195 211 68 langone langone PROPN fnp-5195 211 69 medical medical ADJ fnp-5195 211 70 center center NOUN fnp-5195 211 71 , , PUNCT fnp-5195 211 72 new new PROPN fnp-5195 211 73 york york PROPN fnp-5195 211 74 , , PUNCT fnp-5195 211 75 ny ny PROPN fnp-5195 211 76 , , PUNCT fnp-5195 211 77 usa usa PROPN fnp-5195 211 78 papillary papillary PROPN fnp-5195 211 79 tumor tumor NOUN fnp-5195 211 80 of of ADP fnp-5195 211 81 the the DET fnp-5195 211 82 pineal pineal NOUN fnp-5195 211 83 region region NOUN fnp-5195 211 84 ( ( PUNCT fnp-5195 211 85 ptpr ptpr PROPN fnp-5195 211 86 ) ) PUNCT fnp-5195 211 87 is be AUX fnp-5195 211 88 a a DET fnp-5195 211 89 rare rare ADJ fnp-5195 211 90 neuro neuro NOUN fnp-5195 211 91 - - PUNCT fnp-5195 211 92 epithelial epithelial ADJ fnp-5195 211 93 tumor tumor NOUN fnp-5195 211 94 arising arise VERB fnp-5195 211 95 in in ADP fnp-5195 211 96 the the DET fnp-5195 211 97 pineal pineal NOUN fnp-5195 211 98 region region NOUN fnp-5195 211 99 characterized characterize VERB fnp-5195 211 100 typically typically ADV fnp-5195 211 101 by by ADP fnp-5195 211 102 papillary papillary ADJ fnp-5195 211 103 and and CCONJ fnp-5195 211 104 solid solid ADJ fnp-5195 211 105 architecture architecture NOUN fnp-5195 211 106 with with ADP fnp-5195 211 107 epithelial epithelial ADJ fnp-5195 211 108 - - PUNCT fnp-5195 211 109 like like ADJ fnp-5195 211 110 cells cell NOUN fnp-5195 211 111 and and CCONJ fnp-5195 211 112 reactivity reactivity NOUN fnp-5195 211 113 for for ADP fnp-5195 211 114 cytokeratins cytokeratin NOUN fnp-5195 211 115 , , PUNCT fnp-5195 211 116 while while SCONJ fnp-5195 211 117 subependymal subependymal ADJ fnp-5195 211 118 giant giant ADJ fnp-5195 211 119 cell cell NOUN fnp-5195 211 120 tumor tumor NOUN fnp-5195 211 121 ( ( PUNCT fnp-5195 211 122 sega sega NOUN fnp-5195 211 123 ) ) PUNCT fnp-5195 211 124 is be AUX fnp-5195 211 125 a a DET fnp-5195 211 126 periventricular periventricular ADJ fnp-5195 211 127 tumor tumor NOUN fnp-5195 211 128 composed compose VERB fnp-5195 211 129 of of ADP fnp-5195 211 130 large large ADJ fnp-5195 211 131 ganglion ganglion NOUN fnp-5195 211 132 - - PUNCT fnp-5195 211 133 like like ADJ fnp-5195 211 134 astrocytes astrocyte NOUN fnp-5195 211 135 . . PUNCT fnp-5195 212 1 here here ADV fnp-5195 212 2 we we PRON fnp-5195 212 3 describe describe VERB fnp-5195 212 4 the the DET fnp-5195 212 5 case case NOUN fnp-5195 212 6 of of ADP fnp-5195 212 7 75 75 NUM fnp-5195 212 8 - - PUNCT fnp-5195 212 9 year year NOUN fnp-5195 212 10 - - PUNCT fnp-5195 212 11 old old ADJ fnp-5195 212 12 man man NOUN fnp-5195 212 13 with with ADP fnp-5195 212 14 a a DET fnp-5195 212 15 slowly slowly ADV fnp-5195 212 16 enlarging enlarge VERB fnp-5195 212 17 superior superior ADJ fnp-5195 212 18 cerebral cerebral ADJ fnp-5195 212 19 aqueduct aqueduct NOUN fnp-5195 212 20 mass mass NOUN fnp-5195 212 21 first first ADV fnp-5195 212 22 discovered discover VERB fnp-5195 212 23 and and CCONJ fnp-5195 212 24 followed follow VERB fnp-5195 212 25 over over ADP fnp-5195 212 26 six six NUM fnp-5195 212 27 years year NOUN fnp-5195 212 28 prior prior ADV fnp-5195 212 29 to to ADP fnp-5195 212 30 biopsy biopsy NOUN fnp-5195 212 31 . . PUNCT fnp-5195 213 1 given give VERB fnp-5195 213 2 its its PRON fnp-5195 213 3 increasing increase VERB fnp-5195 213 4 size size NOUN fnp-5195 213 5 a a DET fnp-5195 213 6 small small ADJ fnp-5195 213 7 biopsy biopsy NOUN fnp-5195 213 8 was be AUX fnp-5195 213 9 performed perform VERB fnp-5195 213 10 which which PRON fnp-5195 213 11 was be AUX fnp-5195 213 12 characterized characterize VERB fnp-5195 213 13 by by ADP fnp-5195 213 14 large large ADJ fnp-5195 213 15 pleomorphic pleomorphic ADJ fnp-5195 213 16 ganglion ganglion NOUN fnp-5195 213 17 - - PUNCT fnp-5195 213 18 like like ADJ fnp-5195 213 19 giant giant ADJ fnp-5195 213 20 cells cell NOUN fnp-5195 213 21 with with ADP fnp-5195 213 22 abundant abundant ADJ fnp-5195 213 23 cytoplasm cytoplasm ADJ fnp-5195 213 24 and and CCONJ fnp-5195 213 25 prominent prominent ADJ fnp-5195 213 26 nucleoli nucleolus NOUN fnp-5195 213 27 . . PUNCT fnp-5195 214 1 immunohistochemistry immunohistochemistry NOUN fnp-5195 214 2 showed show VERB fnp-5195 214 3 that that SCONJ fnp-5195 214 4 tumor tumor NOUN fnp-5195 214 5 cells cell NOUN fnp-5195 214 6 were be AUX fnp-5195 214 7 strongly strongly ADV fnp-5195 214 8 positive positive ADJ fnp-5195 214 9 for for ADP fnp-5195 214 10 s100 s100 PROPN fnp-5195 214 11 , , PUNCT fnp-5195 214 12 but but CCONJ fnp-5195 214 13 negative negative ADJ fnp-5195 214 14 for for ADP fnp-5195 214 15 gfap gfap ADJ fnp-5195 214 16 . . PUNCT fnp-5195 215 1 despite despite SCONJ fnp-5195 215 2 the the DET fnp-5195 215 3 patient patient NOUN fnp-5195 215 4 not not PART fnp-5195 215 5 carrying carry VERB fnp-5195 215 6 a a DET fnp-5195 215 7 diagnosis diagnosis NOUN fnp-5195 215 8 of of ADP fnp-5195 215 9 tuberous tuberous ADJ fnp-5195 215 10 sclerosis sclerosis NOUN fnp-5195 215 11 , , PUNCT fnp-5195 215 12 given give VERB fnp-5195 215 13 the the DET fnp-5195 215 14 ventricular ventricular ADJ fnp-5195 215 15 location location NOUN fnp-5195 215 16 , , PUNCT fnp-5195 215 17 histologic histologic ADJ fnp-5195 215 18 appearance appearance NOUN fnp-5195 215 19 , , PUNCT fnp-5195 215 20 and and CCONJ fnp-5195 215 21 immunohistochemical immunohistochemical ADJ fnp-5195 215 22 results result NOUN fnp-5195 215 23 a a DET fnp-5195 215 24 diagnosis diagnosis NOUN fnp-5195 215 25 of of ADP fnp-5195 215 26 a a DET fnp-5195 215 27 low low ADJ fnp-5195 215 28 grade grade NOUN fnp-5195 215 29 tumor tumor NOUN fnp-5195 215 30 consistent consistent ADJ fnp-5195 215 31 with with ADP fnp-5195 215 32 subependymal subependymal ADJ fnp-5195 215 33 giant giant ADJ fnp-5195 215 34 cell cell NOUN fnp-5195 215 35 astrocytoma astrocytoma NOUN fnp-5195 215 36 ( ( PUNCT fnp-5195 215 37 sega sega NOUN fnp-5195 215 38 ) ) PUNCT fnp-5195 215 39 was be AUX fnp-5195 215 40 issued issue VERB fnp-5195 215 41 , , PUNCT fnp-5195 215 42 with with ADP fnp-5195 215 43 outside outside ADJ fnp-5195 215 44 expert expert NOUN fnp-5195 215 45 consultation consultation NOUN fnp-5195 215 46 in in ADP fnp-5195 215 47 agreement agreement NOUN fnp-5195 215 48 with with ADP fnp-5195 215 49 this this DET fnp-5195 215 50 interpretation interpretation NOUN fnp-5195 215 51 . . PUNCT fnp-5195 216 1 subsequently subsequently ADV fnp-5195 216 2 , , PUNCT fnp-5195 216 3 despite despite SCONJ fnp-5195 216 4 surgery surgery NOUN fnp-5195 216 5 the the DET fnp-5195 216 6 mass mass NOUN fnp-5195 216 7 continued continue VERB fnp-5195 216 8 to to PART fnp-5195 216 9 slowly slowly ADV fnp-5195 216 10 grow grow VERB fnp-5195 216 11 over over ADP fnp-5195 216 12 the the DET fnp-5195 216 13 next next ADJ fnp-5195 216 14 few few ADJ fnp-5195 216 15 years year NOUN fnp-5195 216 16 and and CCONJ fnp-5195 216 17 the the DET fnp-5195 216 18 decision decision NOUN fnp-5195 216 19 was be AUX fnp-5195 216 20 made make VERB fnp-5195 216 21 to to PART fnp-5195 216 22 perform perform VERB fnp-5195 216 23 next next ADJ fnp-5195 216 24 generation generation NOUN fnp-5195 216 25 and and CCONJ fnp-5195 216 26 methylation methylation NOUN fnp-5195 216 27 sequencing sequence VERB fnp-5195 216 28 4 4 NUM fnp-5195 216 29 years year NOUN fnp-5195 216 30 following follow VERB fnp-5195 216 31 the the DET fnp-5195 216 32 initial initial ADJ fnp-5195 216 33 biopsy biopsy NOUN fnp-5195 216 34 . . PUNCT fnp-5195 217 1 next next ADJ fnp-5195 217 2 generation generation NOUN fnp-5195 217 3 sequencing sequencing NOUN fnp-5195 217 4 returned return VERB fnp-5195 217 5 only only ADV fnp-5195 217 6 the the DET fnp-5195 217 7 presence presence NOUN fnp-5195 217 8 of of ADP fnp-5195 217 9 an an DET fnp-5195 217 10 nf2 nf2 ADJ fnp-5195 217 11 mutation mutation NOUN fnp-5195 217 12 , , PUNCT fnp-5195 217 13 while while SCONJ fnp-5195 217 14 methylation methylation NOUN fnp-5195 217 15 sequencing sequencing NOUN fnp-5195 217 16 was be AUX fnp-5195 217 17 a a DET fnp-5195 217 18 match match NOUN fnp-5195 217 19 for for ADP fnp-5195 217 20 papillary papillary ADJ fnp-5195 217 21 tumor tumor NOUN fnp-5195 217 22 of of ADP fnp-5195 217 23 the the DET fnp-5195 217 24 pineal pineal NOUN fnp-5195 217 25 region region NOUN fnp-5195 217 26 . . PUNCT fnp-5195 218 1 subsequent subsequent ADJ fnp-5195 218 2 immunohistochemistry immunohistochemistry NOUN fnp-5195 218 3 for for ADP fnp-5195 218 4 keratin keratin NOUN fnp-5195 218 5 ae1/3 ae1/3 PRON fnp-5195 218 6 was be AUX fnp-5195 218 7 strongly strongly ADV fnp-5195 218 8 positive positive ADJ fnp-5195 218 9 on on ADP fnp-5195 218 10 the the DET fnp-5195 218 11 original original ADJ fnp-5195 218 12 biopsy biopsy NOUN fnp-5195 218 13 , , PUNCT fnp-5195 218 14 consistent consistent ADJ fnp-5195 218 15 with with ADP fnp-5195 218 16 this this DET fnp-5195 218 17 new new ADJ fnp-5195 218 18 diagnosis diagnosis NOUN fnp-5195 218 19 . . PUNCT fnp-5195 219 1 this this DET fnp-5195 219 2 case case NOUN fnp-5195 219 3 demonstrates demonstrate VERB fnp-5195 219 4 the the DET fnp-5195 219 5 utility utility NOUN fnp-5195 219 6 of of ADP fnp-5195 219 7 methylation methylation NOUN fnp-5195 219 8 sequencing sequence VERB fnp-5195 219 9 , , PUNCT fnp-5195 219 10 particularly particularly ADV fnp-5195 219 11 when when SCONJ fnp-5195 219 12 biologic biologic NOUN fnp-5195 219 13 behavior behavior NOUN fnp-5195 219 14 and and CCONJ fnp-5195 219 15 sequencing sequence VERB fnp-5195 219 16 results result NOUN fnp-5195 219 17 do do AUX fnp-5195 219 18 not not PART fnp-5195 219 19 correlate correlate VERB fnp-5195 219 20 with with ADP fnp-5195 219 21 histologic histologic ADJ fnp-5195 219 22 diagnosis diagnosis NOUN fnp-5195 219 23 . . PUNCT fnp-5195 219 24     SPACE fnp-5195 220 1 abstract abstract ADJ fnp-5195 220 2 18 18 NUM fnp-5195 220 3 free free ADJ fnp-5195 220 4 neuropathol neuropathol NOUN fnp-5195 220 5 4:20:21 4:20:21 NUM fnp-5195 220 6 ethical ethical ADJ fnp-5195 220 7 considerations consideration NOUN fnp-5195 220 8 in in ADP fnp-5195 220 9 the the DET fnp-5195 220 10 use use NOUN fnp-5195 220 11 of of ADP fnp-5195 220 12 dna dna PROPN fnp-5195 220 13 methylation methylation NOUN fnp-5195 220 14 profiling profiling NOUN fnp-5195 220 15 for for ADP fnp-5195 220 16 tumor tumor NOUN fnp-5195 220 17 diagnostics diagnostic NOUN fnp-5195 220 18 kyle kyle PROPN fnp-5195 220 19 s. s. PROPN fnp-5195 220 20 conway1 conway1 PROPN fnp-5195 220 21 , , PUNCT fnp-5195 220 22 pouya pouya PROPN fnp-5195 220 23 jamshidi2 jamshidi2 PROPN fnp-5195 220 24 , , PUNCT fnp-5195 220 25 lauren lauren PROPN fnp-5195 220 26 b. b. PROPN fnp-5195 220 27 smith1 smith1 PROPN fnp-5195 220 28 1 1 NUM fnp-5195 220 29 department department NOUN fnp-5195 220 30 of of ADP fnp-5195 220 31 pathology pathology PROPN fnp-5195 220 32 , , PUNCT fnp-5195 220 33 university university PROPN fnp-5195 220 34 of of ADP fnp-5195 220 35 michigan michigan PROPN fnp-5195 220 36 , , PUNCT fnp-5195 220 37 ann ann PROPN fnp-5195 220 38 arbor arbor PROPN fnp-5195 220 39 , , PUNCT fnp-5195 220 40 mi mi PROPN fnp-5195 220 41 , , PUNCT fnp-5195 220 42 usa usa PROPN fnp-5195 220 43 2 2 NUM fnp-5195 220 44 department department NOUN fnp-5195 220 45 of of ADP fnp-5195 220 46 pathology pathology PROPN fnp-5195 220 47 , , PUNCT fnp-5195 220 48 northwestern northwestern ADJ fnp-5195 220 49 university university NOUN fnp-5195 220 50 , , PUNCT fnp-5195 220 51 chicago chicago PROPN fnp-5195 220 52 , , PUNCT fnp-5195 220 53 il il PROPN fnp-5195 220 54 , , PUNCT fnp-5195 220 55 usa usa PROPN fnp-5195 220 56 dna dna PROPN fnp-5195 220 57 methylation methylation NOUN fnp-5195 220 58 profiling profiling NOUN fnp-5195 220 59 has have AUX fnp-5195 220 60 become become VERB fnp-5195 220 61 essential essential ADJ fnp-5195 220 62 for for ADP fnp-5195 220 63 cns cns PROPN fnp-5195 220 64 tumor tumor NOUN fnp-5195 220 65 classification classification NOUN fnp-5195 220 66 . . PUNCT fnp-5195 221 1 unlike unlike ADP fnp-5195 221 2 traditional traditional ADJ fnp-5195 221 3 molecular molecular ADJ fnp-5195 221 4 testing testing NOUN fnp-5195 221 5 , , PUNCT fnp-5195 221 6 methylation methylation NOUN fnp-5195 221 7 profiling profiling NOUN fnp-5195 221 8 does do AUX fnp-5195 221 9 not not PART fnp-5195 221 10 interrogate interrogate VERB fnp-5195 221 11 specific specific ADJ fnp-5195 221 12 genetic genetic ADJ fnp-5195 221 13 alterations alteration NOUN fnp-5195 221 14 . . PUNCT fnp-5195 222 1 rather rather ADV fnp-5195 222 2 , , PUNCT fnp-5195 222 3 it it PRON fnp-5195 222 4 evaluates evaluate VERB fnp-5195 222 5 a a DET fnp-5195 222 6 genome genome NOUN fnp-5195 222 7 - - PUNCT fnp-5195 222 8 wide wide ADJ fnp-5195 222 9 methylation methylation NOUN fnp-5195 222 10 profile profile NOUN fnp-5195 222 11 , , PUNCT fnp-5195 222 12 typically typically ADV fnp-5195 222 13 in in ADP fnp-5195 222 14 conjunction conjunction NOUN fnp-5195 222 15 with with ADP fnp-5195 222 16 a a DET fnp-5195 222 17 machine machine NOUN fnp-5195 222 18 - - PUNCT fnp-5195 222 19 learning learn VERB fnp-5195 222 20 classifier classifier NOUN fnp-5195 222 21 that that PRON fnp-5195 222 22 assigns assign VERB fnp-5195 222 23 a a DET fnp-5195 222 24 diagnostic diagnostic ADJ fnp-5195 222 25 category category NOUN fnp-5195 222 26 . . PUNCT fnp-5195 223 1 patients patient NOUN fnp-5195 223 2 benefit benefit VERB fnp-5195 223 3 from from ADP fnp-5195 223 4 an an DET fnp-5195 223 5 unprecedented unprecedented ADJ fnp-5195 223 6 ability ability NOUN fnp-5195 223 7 to to PART fnp-5195 223 8 accurately accurately ADV fnp-5195 223 9 diagnose diagnose VERB fnp-5195 223 10 and and CCONJ fnp-5195 223 11 classify classify VERB fnp-5195 223 12 tumors tumor NOUN fnp-5195 223 13 , , PUNCT fnp-5195 223 14 but but CCONJ fnp-5195 223 15 there there PRON fnp-5195 223 16 is be VERB fnp-5195 223 17 little little ADJ fnp-5195 223 18 formal formal ADJ fnp-5195 223 19 evaluation evaluation NOUN fnp-5195 223 20 of of ADP fnp-5195 223 21 the the DET fnp-5195 223 22 unique unique ADJ fnp-5195 223 23 ethical ethical ADJ fnp-5195 223 24 considerations consideration NOUN fnp-5195 223 25 raised raise VERB fnp-5195 223 26 by by ADP fnp-5195 223 27 this this DET fnp-5195 223 28 modality modality NOUN fnp-5195 223 29 . . PUNCT fnp-5195 224 1 our our PRON fnp-5195 224 2 objective objective NOUN fnp-5195 224 3 is be AUX fnp-5195 224 4 to to PART fnp-5195 224 5 apply apply VERB fnp-5195 224 6 principles principle NOUN fnp-5195 224 7 of of ADP fnp-5195 224 8 medical medical ADJ fnp-5195 224 9 ethics ethic NOUN fnp-5195 224 10 to to ADP fnp-5195 224 11 the the DET fnp-5195 224 12 use use NOUN fnp-5195 224 13 of of ADP fnp-5195 224 14 methylation methylation NOUN fnp-5195 224 15 profiling profiling NOUN fnp-5195 224 16 , , PUNCT fnp-5195 224 17 with with ADP fnp-5195 224 18 a a DET fnp-5195 224 19 focus focus NOUN fnp-5195 224 20 on on ADP fnp-5195 224 21 three three NUM fnp-5195 224 22 principles principle NOUN fnp-5195 224 23 : : PUNCT fnp-5195 224 24 ( ( PUNCT fnp-5195 224 25 1 1 X fnp-5195 224 26 ) ) PUNCT fnp-5195 224 27 informed informed ADJ fnp-5195 224 28 consent consent NOUN fnp-5195 224 29 : : PUNCT fnp-5195 224 30 the the DET fnp-5195 224 31 diagnostic diagnostic ADJ fnp-5195 224 32 paradigm paradigm NOUN fnp-5195 224 33 of of ADP fnp-5195 224 34 methylation methylation NOUN fnp-5195 224 35 is be AUX fnp-5195 224 36 complex complex ADJ fnp-5195 224 37 for for ADP fnp-5195 224 38 patients patient NOUN fnp-5195 224 39 and and CCONJ fnp-5195 224 40 clinicians clinician NOUN fnp-5195 224 41 to to PART fnp-5195 224 42 understand understand VERB fnp-5195 224 43 and and CCONJ fnp-5195 224 44 risks risk VERB fnp-5195 224 45 confusion confusion NOUN fnp-5195 224 46 regarding regard VERB fnp-5195 224 47 the the DET fnp-5195 224 48 diagnostic diagnostic ADJ fnp-5195 224 49 significance significance NOUN fnp-5195 224 50 of of ADP fnp-5195 224 51 a a DET fnp-5195 224 52 methylation methylation NOUN fnp-5195 224 53 profile profile NOUN fnp-5195 224 54 . . PUNCT fnp-5195 225 1 patients patient NOUN fnp-5195 225 2 may may AUX fnp-5195 225 3 be be AUX fnp-5195 225 4 unaware unaware ADJ fnp-5195 225 5 of of ADP fnp-5195 225 6 what what PRON fnp-5195 225 7 data datum NOUN fnp-5195 225 8 is be AUX fnp-5195 225 9 stored store VERB fnp-5195 225 10 and and CCONJ fnp-5195 225 11 how how SCONJ fnp-5195 225 12 it it PRON fnp-5195 225 13 will will AUX fnp-5195 225 14 be be AUX fnp-5195 225 15 stored store VERB fnp-5195 225 16 , , PUNCT fnp-5195 225 17 transferred transfer VERB fnp-5195 225 18 , , PUNCT fnp-5195 225 19 and and CCONJ fnp-5195 225 20 re re VERB fnp-5195 225 21 - - VERB fnp-5195 225 22 analyzed analyze VERB fnp-5195 225 23 for for ADP fnp-5195 225 24 clinical clinical ADJ fnp-5195 225 25 and and CCONJ fnp-5195 225 26 research research NOUN fnp-5195 225 27 purposes purpose NOUN fnp-5195 225 28 . . PUNCT fnp-5195 226 1 ( ( PUNCT fnp-5195 226 2 2 2 X fnp-5195 226 3 ) ) PUNCT fnp-5195 226 4 harm harm NOUN fnp-5195 226 5 to to ADP fnp-5195 226 6 patients patient NOUN fnp-5195 226 7 : : PUNCT fnp-5195 226 8 methylation methylation NOUN fnp-5195 226 9 profiling profiling NOUN fnp-5195 226 10 generates generate VERB fnp-5195 226 11 epigenetic epigenetic ADJ fnp-5195 226 12 data datum NOUN fnp-5195 226 13 that that PRON fnp-5195 226 14 exists exist VERB fnp-5195 226 15 indefinitely indefinitely ADV fnp-5195 226 16 and and CCONJ fnp-5195 226 17 can can AUX fnp-5195 226 18 be be AUX fnp-5195 226 19 analyzed analyze VERB fnp-5195 226 20 in in ADP fnp-5195 226 21 a a DET fnp-5195 226 22 dynamic dynamic ADJ fnp-5195 226 23 fashion fashion NOUN fnp-5195 226 24 . . PUNCT fnp-5195 227 1 as as SCONJ fnp-5195 227 2 new new ADJ fnp-5195 227 3 classifiers classifier NOUN fnp-5195 227 4 are be AUX fnp-5195 227 5 implemented implement VERB fnp-5195 227 6 , , PUNCT fnp-5195 227 7 a a DET fnp-5195 227 8 previously previously ADV fnp-5195 227 9 unclassifiable unclassifiable ADJ fnp-5195 227 10 tumor tumor NOUN fnp-5195 227 11 may may AUX fnp-5195 227 12 become become VERB fnp-5195 227 13 classifiable classifiable ADJ fnp-5195 227 14 without without ADP fnp-5195 227 15 re re VERB fnp-5195 227 16 - - VERB fnp-5195 227 17 sequencing sequencing ADJ fnp-5195 227 18 or or CCONJ fnp-5195 227 19 a a DET fnp-5195 227 20 clinically clinically ADV fnp-5195 227 21 significant significant ADJ fnp-5195 227 22 change change NOUN fnp-5195 227 23 in in ADP fnp-5195 227 24 methylation methylation NOUN fnp-5195 227 25 class class NOUN fnp-5195 227 26 may may AUX fnp-5195 227 27 occur occur VERB fnp-5195 227 28 . . PUNCT fnp-5195 228 1 ( ( PUNCT fnp-5195 228 2 3 3 X fnp-5195 228 3 ) ) PUNCT fnp-5195 228 4 justice justice NOUN fnp-5195 228 5 and and CCONJ fnp-5195 228 6 resource resource NOUN fnp-5195 228 7 utilization utilization NOUN fnp-5195 228 8 : : PUNCT fnp-5195 228 9 the the DET fnp-5195 228 10 extensive extensive ADJ fnp-5195 228 11 granularity granularity NOUN fnp-5195 228 12 of of ADP fnp-5195 228 13 diagnostic diagnostic ADJ fnp-5195 228 14 categories category NOUN fnp-5195 228 15 defined define VERB fnp-5195 228 16 by by ADP fnp-5195 228 17 methylation methylation NOUN fnp-5195 228 18 profiling profiling NOUN fnp-5195 228 19 creates create VERB fnp-5195 228 20 a a DET fnp-5195 228 21 risk risk NOUN fnp-5195 228 22 of of ADP fnp-5195 228 23 over over ADP fnp-5195 228 24 - - PUNCT fnp-5195 228 25 testing testing NOUN fnp-5195 228 26 that that PRON fnp-5195 228 27 may may AUX fnp-5195 228 28 not not PART fnp-5195 228 29 generate generate VERB fnp-5195 228 30 clinically clinically ADV fnp-5195 228 31 actionable actionable ADJ fnp-5195 228 32 results result NOUN fnp-5195 228 33 . . PUNCT fnp-5195 229 1 the the DET fnp-5195 229 2 use use NOUN fnp-5195 229 3 of of ADP fnp-5195 229 4 machine machine NOUN fnp-5195 229 5 learning learning NOUN fnp-5195 229 6 carries carry VERB fnp-5195 229 7 specific specific ADJ fnp-5195 229 8 considerations consideration NOUN fnp-5195 229 9 of of ADP fnp-5195 229 10 justice justice NOUN fnp-5195 229 11 , , PUNCT fnp-5195 229 12 including include VERB fnp-5195 229 13 inherent inherent ADJ fnp-5195 229 14 biases bias NOUN fnp-5195 229 15 in in ADP fnp-5195 229 16 the the DET fnp-5195 229 17 populations population NOUN fnp-5195 229 18 used use VERB fnp-5195 229 19 for for ADP fnp-5195 229 20 classifier classifier ADJ fnp-5195 229 21 generation generation NOUN fnp-5195 229 22 . . PUNCT fnp-5195 230 1 neuropathologists neuropathologist NOUN fnp-5195 230 2 should should AUX fnp-5195 230 3 keep keep VERB fnp-5195 230 4 these these DET fnp-5195 230 5 ethical ethical ADJ fnp-5195 230 6 considerations consideration NOUN fnp-5195 230 7 in in ADP fnp-5195 230 8 mind mind NOUN fnp-5195 230 9 when when SCONJ fnp-5195 230 10 implementing implement VERB fnp-5195 230 11 methylation methylation NOUN fnp-5195 230 12 as as ADP fnp-5195 230 13 a a DET fnp-5195 230 14 clinical clinical ADJ fnp-5195 230 15 test test NOUN fnp-5195 230 16 or or CCONJ fnp-5195 230 17 in in ADP fnp-5195 230 18 clinical clinical ADJ fnp-5195 230 19 practice practice NOUN fnp-5195 230 20 . . PUNCT fnp-5195 231 1 copyright copyright NOUN fnp-5195 231 2 : : PUNCT fnp-5195 231 3 © © PROPN fnp-5195 231 4 2023 2023 NUM fnp-5195 231 5 the the DET fnp-5195 231 6 author(s author(s NOUN fnp-5195 231 7 ) ) PUNCT fnp-5195 231 8 . . PUNCT fnp-5195 232 1 this this PRON fnp-5195 232 2 is be AUX fnp-5195 232 3 an an DET fnp-5195 232 4 open open ADJ fnp-5195 232 5 access access NOUN fnp-5195 232 6 article article NOUN fnp-5195 232 7 distributed distribute VERB fnp-5195 232 8 under under ADP fnp-5195 232 9 the the DET fnp-5195 232 10 terms term NOUN fnp-5195 232 11 of of ADP fnp-5195 232 12 the the DET fnp-5195 232 13 creative creative ADJ fnp-5195 232 14 commons common NOUN fnp-5195 232 15 attribution attribution NOUN fnp-5195 232 16 4.0 4.0 NUM fnp-5195 232 17 international international ADJ fnp-5195 232 18 license license NOUN fnp-5195 232 19 ( ( PUNCT fnp-5195 232 20 https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/ PROPN fnp-5195 232 21 ) ) PUNCT fnp-5195 232 22 , , PUNCT fnp-5195 232 23 which which PRON fnp-5195 232 24 permits permit VERB fnp-5195 232 25 unrestricted unrestricted ADJ fnp-5195 232 26 use use NOUN fnp-5195 232 27 , , PUNCT fnp-5195 232 28 distribution distribution NOUN fnp-5195 232 29 , , PUNCT fnp-5195 232 30 and and CCONJ fnp-5195 232 31 reproduction reproduction NOUN fnp-5195 232 32 in in ADP fnp-5195 232 33 any any DET fnp-5195 232 34 medium medium NOUN fnp-5195 232 35 , , PUNCT fnp-5195 232 36 provided provide VERB fnp-5195 232 37 the the DET fnp-5195 232 38 original original ADJ fnp-5195 232 39 author author NOUN fnp-5195 232 40 and and CCONJ fnp-5195 232 41 source source NOUN fnp-5195 232 42 are be AUX fnp-5195 232 43 credited credit VERB fnp-5195 232 44 , , PUNCT fnp-5195 232 45 a a DET fnp-5195 232 46 link link NOUN fnp-5195 232 47 to to ADP fnp-5195 232 48 the the DET fnp-5195 232 49 creative creative ADJ fnp-5195 232 50 commons common NOUN fnp-5195 232 51 license license NOUN fnp-5195 232 52 is be AUX fnp-5195 232 53 provided provide VERB fnp-5195 232 54 , , PUNCT fnp-5195 232 55 and and CCONJ fnp-5195 232 56 any any DET fnp-5195 232 57 changes change NOUN fnp-5195 232 58 are be AUX fnp-5195 232 59 indicated indicate VERB fnp-5195 232 60 . . PUNCT fnp-5195 233 1 the the DET fnp-5195 233 2 creative creative ADJ fnp-5195 233 3 commons common NOUN fnp-5195 233 4 public public ADJ fnp-5195 233 5 domain domain NOUN fnp-5195 233 6 dedication dedication NOUN fnp-5195 233 7 waiver waiver NOUN fnp-5195 233 8 ( ( PUNCT fnp-5195 233 9 https://creativecommons.org/publicdomain/zero/1.0/ https://creativecommons.org/publicdomain/zero/1.0/ PROPN fnp-5195 233 10 ) ) PUNCT fnp-5195 233 11 applies apply VERB fnp-5195 233 12 to to ADP fnp-5195 233 13 the the DET fnp-5195 233 14 data datum NOUN fnp-5195 233 15 made make VERB fnp-5195 233 16 available available ADJ fnp-5195 233 17 in in ADP fnp-5195 233 18 this this DET fnp-5195 233 19 article article NOUN fnp-5195 233 20 , , PUNCT fnp-5195 233 21 unless unless SCONJ fnp-5195 233 22 otherwise otherwise ADV fnp-5195 233 23 stated state VERB fnp-5195 233 24 . . PUNCT