id	sid	tid	token	lemma	pos
fnp-5337	1	1	searching	search	VERB
fnp-5337	1	2	for	for	ADP
fnp-5337	1	3	a	a	DET
fnp-5337	1	4	cut	cut	VERB
fnp-5337	1	5	-	-	PUNCT
fnp-5337	1	6	off	off	ADP
fnp-5337	1	7	point	point	NOUN
fnp-5337	1	8	for	for	ADP
fnp-5337	1	9	p53	p53	NOUN
fnp-5337	1	10	immunohistochemistry	immunohistochemistry	NOUN
fnp-5337	1	11	as	as	ADP
fnp-5337	1	12	evidence	evidence	NOUN
fnp-5337	1	13	of	of	ADP
fnp-5337	1	14	tp53	tp53	PROPN
fnp-5337	1	15	mutations	mutation	NOUN
fnp-5337	1	16	feel	feel	VERB
fnp-5337	1	17	free	free	ADJ
fnp-5337	1	18	to	to	PART
fnp-5337	1	19	add	add	VERB
fnp-5337	1	20	comments	comment	NOUN
fnp-5337	1	21	by	by	ADP
fnp-5337	1	22	clicking	click	VERB
fnp-5337	1	23	these	these	DET
fnp-5337	1	24	icons	icon	NOUN
fnp-5337	1	25	on	on	ADP
fnp-5337	1	26	the	the	DET
fnp-5337	1	27	sidebar	sidebar	NOUN
fnp-5337	1	28	free	free	ADJ
fnp-5337	1	29	neuropathology	neuropathology	NOUN
fnp-5337	1	30	5:6	5:6	NUM
fnp-5337	1	31	(	(	PUNCT
fnp-5337	1	32	2024	2024	NUM
fnp-5337	1	33	)	)	PUNCT
fnp-5337	1	34	letter	letter	NOUN
fnp-5337	1	35	searching	search	VERB
fnp-5337	1	36	for	for	ADP
fnp-5337	1	37	a	a	DET
fnp-5337	1	38	cut	cut	VERB
fnp-5337	1	39	-	-	PUNCT
fnp-5337	1	40	off	off	ADP
fnp-5337	1	41	point	point	NOUN
fnp-5337	1	42	for	for	ADP
fnp-5337	1	43	p53	p53	NOUN
fnp-5337	1	44	immunohistochemistry	immunohistochemistry	NOUN
fnp-5337	1	45	as	as	ADP
fnp-5337	1	46	evidence	evidence	NOUN
fnp-5337	1	47	of	of	ADP
fnp-5337	1	48	tp53	tp53	PROPN
fnp-5337	1	49	mutations	mutation	NOUN
fnp-5337	1	50	ilay	ilay	VERB
fnp-5337	1	51	caliskan1	caliskan1	PROPN
fnp-5337	1	52	,	,	PUNCT
fnp-5337	1	53	rufei	rufei	PROPN
fnp-5337	1	54	lu1	lu1	PROPN
fnp-5337	1	55	,	,	PUNCT
fnp-5337	1	56	cristine	cristine	PROPN
fnp-5337	1	57	szu	szu	PROPN
fnp-5337	1	58	lyn	lyn	PROPN
fnp-5337	1	59	ding1,2	ding1,2	PROPN
fnp-5337	1	60	,	,	PUNCT
fnp-5337	1	61	francineide	francineide	PROPN
fnp-5337	1	62	sadala	sadala	PROPN
fnp-5337	1	63	de	de	PROPN
fnp-5337	1	64	souza1,3	souza1,3	PROPN
fnp-5337	1	65	,	,	PUNCT
fnp-5337	1	66	arie	arie	PROPN
fnp-5337	1	67	perry1	perry1	PROPN
fnp-5337	1	68	,	,	PUNCT
fnp-5337	1	69	tarik	tarik	PROPN
fnp-5337	1	70	tihan1	tihan1	PROPN
fnp-5337	1	71	department	department	PROPN
fnp-5337	1	72	of	of	ADP
fnp-5337	1	73	pathology	pathology	PROPN
fnp-5337	1	74	,	,	PUNCT
fnp-5337	1	75	neuropathology	neuropathology	NOUN
fnp-5337	1	76	division	division	NOUN
fnp-5337	1	77	,	,	PUNCT
fnp-5337	1	78	ucsf	ucsf	PROPN
fnp-5337	1	79	medical	medical	ADJ
fnp-5337	1	80	center	center	PROPN
fnp-5337	1	81	,	,	PUNCT
fnp-5337	1	82	san	san	PROPN
fnp-5337	1	83	francisco	francisco	PROPN
fnp-5337	1	84	,	,	PUNCT
fnp-5337	1	85	ca	ca	PROPN
fnp-5337	1	86	94143	94143	NUM
fnp-5337	1	87	,	,	PUNCT
fnp-5337	1	88	usa	usa	PROPN
fnp-5337	1	89	current	current	ADJ
fnp-5337	1	90	address	address	NOUN
fnp-5337	1	91	:	:	PUNCT
fnp-5337	1	92	division	division	NOUN
fnp-5337	1	93	of	of	ADP
fnp-5337	1	94	anatomical	anatomical	ADJ
fnp-5337	1	95	pathology	pathology	NOUN
fnp-5337	1	96	,	,	PUNCT
fnp-5337	1	97	changi	changi	PROPN
fnp-5337	1	98	general	general	PROPN
fnp-5337	1	99	hospital	hospital	PROPN
fnp-5337	1	100	,	,	PUNCT
fnp-5337	1	101	singapore	singapore	PROPN
fnp-5337	1	102	,	,	PUNCT
fnp-5337	1	103	529889	529889	NUM
fnp-5337	1	104	,	,	PUNCT
fnp-5337	1	105	singapore	singapore	PROPN
fnp-5337	1	106	current	current	ADJ
fnp-5337	1	107	address	address	NOUN
fnp-5337	1	108	:	:	PUNCT
fnp-5337	1	109	associação	associação	PROPN
fnp-5337	1	110	das	das	PROPN
fnp-5337	1	111	pioneiras	pioneiras	PROPN
fnp-5337	1	112	sociais	sociais	PROPN
fnp-5337	1	113	,	,	PUNCT
fnp-5337	1	114	patologia	patologia	PROPN
fnp-5337	1	115	cirúrgica	cirúrgica	PROPN
fnp-5337	1	116	,	,	PUNCT
fnp-5337	1	117	asa	asa	PROPN
fnp-5337	1	118	sul	sul	PROPN
fnp-5337	1	119	–	–	PUNCT
fnp-5337	1	120	brasília	brasília	PROPN
fnp-5337	1	121	70335901	70335901	NUM
fnp-5337	1	122	,	,	PUNCT
fnp-5337	1	123	df	df	PROPN
fnp-5337	1	124	brazil	brazil	PROPN
fnp-5337	1	125	,	,	PUNCT
fnp-5337	1	126	brazil	brazil	PROPN
fnp-5337	1	127	corresponding	corresponding	ADJ
fnp-5337	1	128	author	author	NOUN
fnp-5337	1	129	:	:	PUNCT
fnp-5337	1	130	tarik	tarik	PROPN
fnp-5337	1	131	tihan	tihan	PROPN
fnp-5337	1	132	·	·	PUNCT
fnp-5337	1	133	neuropathology	neuropathology	NOUN
fnp-5337	1	134	division	division	NOUN
fnp-5337	1	135	·	·	PUNCT
fnp-5337	1	136	room	room	NOUN
fnp-5337	1	137	m551	m551	PROPN
fnp-5337	1	138	·	·	PUNCT
fnp-5337	1	139	department	department	NOUN
fnp-5337	1	140	of	of	ADP
fnp-5337	1	141	pathology	pathology	PROPN
fnp-5337	1	142	·	·	PUNCT
fnp-5337	1	143	university	university	PROPN
fnp-5337	1	144	of	of	ADP
fnp-5337	1	145	california	california	PROPN
fnp-5337	1	146	san	san	PROPN
fnp-5337	1	147	francisco	francisco	PROPN
fnp-5337	1	148	·	·	PUNCT
fnp-5337	2	1	505	505	NUM
fnp-5337	2	2	 	 	SPACE
fnp-5337	2	3	parnassus	parnassus	PROPN
fnp-5337	2	4	avenue	avenue	PROPN
fnp-5337	2	5	·	·	PUNCT
fnp-5337	2	6	san	san	PROPN
fnp-5337	2	7	francisco	francisco	PROPN
fnp-5337	2	8	·	·	PUNCT
fnp-5337	2	9	ca	ca	PROPN
fnp-5337	2	10	94143	94143	NUM
fnp-5337	2	11	·	·	PUNCT
fnp-5337	2	12	usa	usa	PROPN
fnp-5337	2	13	tarik.tihan@ucsf.edu	tarik.tihan@ucsf.edu	PROPN
fnp-5337	2	14	submitted	submit	VERB
fnp-5337	2	15	:	:	PUNCT
fnp-5337	2	16	23	23	NUM
fnp-5337	2	17	january	january	NOUN
fnp-5337	2	18	2024	2024	NUM
fnp-5337	2	19	accepted	accept	VERB
fnp-5337	2	20	:	:	PUNCT
fnp-5337	2	21	29	29	NUM
fnp-5337	2	22	february	february	NOUN
fnp-5337	2	23	2024	2024	NUM
fnp-5337	2	24	copyedited	copyedit	VERB
fnp-5337	2	25	by	by	ADP
fnp-5337	2	26	:	:	PUNCT
fnp-5337	2	27	jerry	jerry	PROPN
fnp-5337	2	28	lou	lou	PROPN
fnp-5337	2	29	published	publish	VERB
fnp-5337	2	30	:	:	PUNCT
fnp-5337	2	31	12	12	NUM
fnp-5337	2	32	march	march	NOUN
fnp-5337	2	33	2024	2024	NUM
fnp-5337	2	34	https://doi.org/10.17879/freeneuropathology-2024-5337	https://doi.org/10.17879/freeneuropathology-2024-5337	PROPN
fnp-5337	2	35	keywords	keyword	NOUN
fnp-5337	2	36	:	:	PUNCT
fnp-5337	2	37	p53	p53	NOUN
fnp-5337	2	38	,	,	PUNCT
fnp-5337	2	39	immunohistochemistry	immunohistochemistry	NOUN
fnp-5337	2	40	,	,	PUNCT
fnp-5337	2	41	tp53	tp53	PROPN
fnp-5337	2	42	mutation	mutation	NOUN
fnp-5337	2	43	,	,	PUNCT
fnp-5337	2	44	glioma	glioma	NOUN
fnp-5337	2	45	numerous	numerous	ADJ
fnp-5337	2	46	publications	publication	NOUN
fnp-5337	2	47	and	and	CCONJ
fnp-5337	2	48	revised	revise	VERB
fnp-5337	2	49	grading	grade	VERB
fnp-5337	2	50	strategies	strategy	NOUN
fnp-5337	2	51	reiterate	reiterate	VERB
fnp-5337	2	52	the	the	DET
fnp-5337	2	53	relevance	relevance	NOUN
fnp-5337	2	54	of	of	ADP
fnp-5337	2	55	tp53	tp53	PROPN
fnp-5337	2	56	gene	gene	NOUN
fnp-5337	2	57	mutations	mutation	NOUN
fnp-5337	2	58	for	for	ADP
fnp-5337	2	59	adult	adult	NOUN
fnp-5337	2	60	diffuse	diffuse	PROPN
fnp-5337	2	61	gliomas1–3	gliomas1–3	PROPN
fnp-5337	2	62	.	.	PUNCT
fnp-5337	3	1	these	these	DET
fnp-5337	3	2	studies	study	NOUN
fnp-5337	3	3	identify	identify	VERB
fnp-5337	3	4	tp53	tp53	PROPN
fnp-5337	3	5	mutation	mutation	NOUN
fnp-5337	3	6	as	as	ADP
fnp-5337	3	7	a	a	DET
fnp-5337	3	8	frequent	frequent	ADJ
fnp-5337	3	9	alteration	alteration	NOUN
fnp-5337	3	10	in	in	ADP
fnp-5337	3	11	idh	idh	NOUN
fnp-5337	3	12	-	-	PUNCT
fnp-5337	3	13	mutant	mutant	NOUN
fnp-5337	3	14	astrocytomas	astrocytoma	NOUN
fnp-5337	3	15	along	along	ADV
fnp-5337	3	16	with	with	ADP
fnp-5337	3	17	other	other	ADJ
fnp-5337	3	18	critical	critical	ADJ
fnp-5337	3	19	genes	gene	NOUN
fnp-5337	3	20	,	,	PUNCT
fnp-5337	3	21	such	such	ADJ
fnp-5337	3	22	as	as	ADP
fnp-5337	3	23	idh1	idh1	PROPN
fnp-5337	3	24	,	,	PUNCT
fnp-5337	3	25	idh2	idh2	PROPN
fnp-5337	3	26	,	,	PUNCT
fnp-5337	3	27	and	and	CCONJ
fnp-5337	3	28	atrx	atrx	VERB
fnp-5337	3	29	.	.	PUNCT
fnp-5337	4	1	the	the	DET
fnp-5337	4	2	2021	2021	NUM
fnp-5337	4	3	who	who	PRON
fnp-5337	4	4	classification	classification	NOUN
fnp-5337	4	5	of	of	ADP
fnp-5337	4	6	central	central	ADJ
fnp-5337	4	7	nervous	nervous	ADJ
fnp-5337	4	8	system	system	NOUN
fnp-5337	4	9	(	(	PUNCT
fnp-5337	4	10	cns)4	cns)4	PROPN
fnp-5337	4	11	designates	designate	VERB
fnp-5337	4	12	"	"	PUNCT
fnp-5337	4	13	strong	strong	ADJ
fnp-5337	4	14	"	"	PUNCT
fnp-5337	4	15	nuclear	nuclear	ADJ
fnp-5337	4	16	expression	expression	NOUN
fnp-5337	4	17	of	of	ADP
fnp-5337	4	18	p53	p53	NOUN
fnp-5337	4	19	protein	protein	NOUN
fnp-5337	4	20	in	in	ADP
fnp-5337	4	21	greater	great	ADJ
fnp-5337	4	22	than	than	ADP
fnp-5337	4	23	10	10	NUM
fnp-5337	4	24	 	 	SPACE
fnp-5337	4	25	%	%	NOUN
fnp-5337	4	26	of	of	ADP
fnp-5337	4	27	tumor	tumor	NOUN
fnp-5337	4	28	cells	cell	NOUN
fnp-5337	4	29	,	,	PUNCT
fnp-5337	4	30	which	which	PRON
fnp-5337	4	31	implies	imply	VERB
fnp-5337	4	32	the	the	DET
fnp-5337	4	33	presence	presence	NOUN
fnp-5337	4	34	of	of	ADP
fnp-5337	4	35	tp53	tp53	PROPN
fnp-5337	4	36	mutations4	mutations4	PROPN
fnp-5337	4	37	as	as	ADP
fnp-5337	4	38	a	a	DET
fnp-5337	4	39	desirable	desirable	ADJ
fnp-5337	4	40	criterion	criterion	NOUN
fnp-5337	4	41	for	for	ADP
fnp-5337	4	42	idh	idh	NOUN
fnp-5337	4	43	-	-	PUNCT
fnp-5337	4	44	mutant	mutant	NOUN
fnp-5337	4	45	astrocytomas	astrocytoma	NOUN
fnp-5337	4	46	.	.	PUNCT
fnp-5337	5	1	other	other	ADJ
fnp-5337	5	2	studies	study	NOUN
fnp-5337	5	3	have	have	AUX
fnp-5337	5	4	also	also	ADV
fnp-5337	5	5	recognized	recognize	VERB
fnp-5337	5	6	similar	similar	ADJ
fnp-5337	5	7	percentages	percentage	NOUN
fnp-5337	5	8	in	in	ADP
fnp-5337	5	9	adult	adult	NOUN
fnp-5337	5	10	diffuse	diffuse	NOUN
fnp-5337	5	11	gliomas	glioma	NOUN
fnp-5337	5	12	as	as	ADP
fnp-5337	5	13	evidence	evidence	NOUN
fnp-5337	5	14	of	of	ADP
fnp-5337	5	15	tp53	tp53	PROPN
fnp-5337	5	16	mutations	mutation	NOUN
fnp-5337	5	17	.	.	PUNCT
fnp-5337	6	1	to	to	PART
fnp-5337	6	2	incorporate	incorporate	VERB
fnp-5337	6	3	tp53	tp53	PROPN
fnp-5337	6	4	alterations	alteration	NOUN
fnp-5337	6	5	into	into	ADP
fnp-5337	6	6	the	the	DET
fnp-5337	6	7	diagnostic	diagnostic	ADJ
fnp-5337	6	8	work	work	NOUN
fnp-5337	6	9	-	-	PUNCT
fnp-5337	6	10	up	up	NOUN
fnp-5337	6	11	,	,	PUNCT
fnp-5337	6	12	these	these	DET
fnp-5337	6	13	studies	study	NOUN
fnp-5337	6	14	used	use	VERB
fnp-5337	6	15	immunohistochemistry	immunohistochemistry	NOUN
fnp-5337	6	16	as	as	ADP
fnp-5337	6	17	a	a	DET
fnp-5337	6	18	viable	viable	ADJ
fnp-5337	6	19	alternative	alternative	NOUN
fnp-5337	6	20	to	to	PART
fnp-5337	6	21	provide	provide	VERB
fnp-5337	6	22	the	the	DET
fnp-5337	6	23	type	type	NOUN
fnp-5337	6	24	and	and	CCONJ
fnp-5337	6	25	grade	grade	NOUN
fnp-5337	6	26	of	of	ADP
fnp-5337	6	27	diffuse	diffuse	PROPN
fnp-5337	6	28	astrocytomas5	astrocytomas5	PROPN
fnp-5337	6	29	,	,	PUNCT
fnp-5337	6	30	and	and	CCONJ
fnp-5337	6	31	others	other	NOUN
fnp-5337	6	32	recommended	recommend	VERB
fnp-5337	6	33	p53	p53	NOUN
fnp-5337	6	34	protein	protein	NOUN
fnp-5337	6	35	immunohistochemistry	immunohistochemistry	NOUN
fnp-5337	6	36	as	as	ADP
fnp-5337	6	37	a	a	DET
fnp-5337	6	38	reliable	reliable	ADJ
fnp-5337	6	39	means	mean	NOUN
fnp-5337	6	40	of	of	ADP
fnp-5337	6	41	predicting	predict	VERB
fnp-5337	6	42	tp53	tp53	PROPN
fnp-5337	6	43	mutations6,7,8	mutations6,7,8	NUM
fnp-5337	6	44	.	.	PUNCT
fnp-5337	7	1	while	while	SCONJ
fnp-5337	7	2	a	a	DET
fnp-5337	7	3	few	few	ADJ
fnp-5337	7	4	studies	study	NOUN
fnp-5337	7	5	report	report	VERB
fnp-5337	7	6	an	an	DET
fnp-5337	7	7	association	association	NOUN
fnp-5337	7	8	with	with	ADP
fnp-5337	7	9	treatment	treatment	NOUN
fnp-5337	7	10	response	response	NOUN
fnp-5337	7	11	,	,	PUNCT
fnp-5337	7	12	most	most	ADJ
fnp-5337	7	13	studies	study	NOUN
fnp-5337	7	14	do	do	AUX
fnp-5337	7	15	not	not	PART
fnp-5337	7	16	find	find	VERB
fnp-5337	7	17	tp53	tp53	PROPN
fnp-5337	7	18	mutation	mutation	NOUN
fnp-5337	7	19	status	status	NOUN
fnp-5337	7	20	or	or	CCONJ
fnp-5337	7	21	positive	positive	ADJ
fnp-5337	7	22	immunohistochemical	immunohistochemical	ADJ
fnp-5337	7	23	staining	staining	NOUN
fnp-5337	7	24	helpful	helpful	ADJ
fnp-5337	7	25	in	in	ADP
fnp-5337	7	26	determining	determine	VERB
fnp-5337	7	27	biological	biological	ADJ
fnp-5337	7	28	behavior	behavior	NOUN
fnp-5337	7	29	or	or	CCONJ
fnp-5337	7	30	type	type	NOUN
fnp-5337	7	31	of	of	ADP
fnp-5337	7	32	adult	adult	NOUN
fnp-5337	7	33	diffuse	diffuse	PROPN
fnp-5337	7	34	glioma8	glioma8	PROPN
fnp-5337	7	35	.	.	PUNCT
fnp-5337	8	1	contrary	contrary	ADJ
fnp-5337	8	2	to	to	ADP
fnp-5337	8	3	the	the	DET
fnp-5337	8	4	studies	study	NOUN
fnp-5337	8	5	that	that	PRON
fnp-5337	8	6	expressed	express	VERB
fnp-5337	8	7	enthusiasm	enthusiasm	NOUN
fnp-5337	8	8	for	for	ADP
fnp-5337	8	9	p53	p53	NOUN
fnp-5337	8	10	immunohistochemistry	immunohistochemistry	NOUN
fnp-5337	8	11	as	as	ADP
fnp-5337	8	12	a	a	DET
fnp-5337	8	13	predictive	predictive	ADJ
fnp-5337	8	14	marker	marker	NOUN
fnp-5337	8	15	for	for	ADP
fnp-5337	8	16	tp53	tp53	PROPN
fnp-5337	8	17	mutational	mutational	ADJ
fnp-5337	8	18	status7	status7	NOUN
fnp-5337	8	19	,	,	PUNCT
fnp-5337	8	20	studies	study	NOUN
fnp-5337	8	21	as	as	ADV
fnp-5337	8	22	far	far	ADV
fnp-5337	8	23	back	back	ADV
fnp-5337	8	24	as	as	ADP
fnp-5337	8	25	25	25	NUM
fnp-5337	8	26	years	year	NOUN
fnp-5337	8	27	ago	ago	ADV
fnp-5337	8	28	pointed	point	VERB
fnp-5337	8	29	to	to	ADP
fnp-5337	8	30	the	the	DET
fnp-5337	8	31	discordance	discordance	NOUN
fnp-5337	8	32	between	between	ADP
fnp-5337	8	33	p53	p53	NOUN
fnp-5337	8	34	protein	protein	NOUN
fnp-5337	8	35	expression	expression	NOUN
fnp-5337	8	36	and	and	CCONJ
fnp-5337	8	37	tp53	tp53	PROPN
fnp-5337	8	38	mutations9	mutations9	NOUN
fnp-5337	8	39	.	.	PUNCT
fnp-5337	9	1	it	it	PRON
fnp-5337	9	2	was	be	AUX
fnp-5337	9	3	clear	clear	ADJ
fnp-5337	9	4	from	from	ADP
fnp-5337	9	5	these	these	DET
fnp-5337	9	6	earlier	early	ADJ
fnp-5337	9	7	studies	study	NOUN
fnp-5337	9	8	that	that	SCONJ
fnp-5337	9	9	most	most	ADJ
fnp-5337	9	10	gliomas	glioma	NOUN
fnp-5337	9	11	with	with	ADP
fnp-5337	9	12	focal	focal	ADJ
fnp-5337	9	13	p53	p53	NOUN
fnp-5337	9	14	nuclear	nuclear	ADJ
fnp-5337	9	15	immunopositivity	immunopositivity	NOUN
fnp-5337	9	16	do	do	AUX
fnp-5337	9	17	not	not	PART
fnp-5337	9	18	harbor	harbor	VERB
fnp-5337	9	19	tp53	tp53	PROPN
fnp-5337	9	20	mutations9	mutations9	PROPN
fnp-5337	9	21	.	.	PUNCT
fnp-5337	10	1	certain	certain	ADJ
fnp-5337	10	2	alterations	alteration	NOUN
fnp-5337	10	3	in	in	ADP
fnp-5337	10	4	the	the	DET
fnp-5337	10	5	tp53	tp53	PROPN
fnp-5337	10	6	gene	gene	NOUN
fnp-5337	10	7	,	,	PUNCT
fnp-5337	10	8	such	such	ADJ
fnp-5337	10	9	as	as	ADP
fnp-5337	10	10	exon	exon	NOUN
fnp-5337	10	11	4	4	NUM
fnp-5337	10	12	mutations	mutation	NOUN
fnp-5337	10	13	or	or	CCONJ
fnp-5337	10	14	missense	missense	NOUN
fnp-5337	10	15	mutations	mutation	NOUN
fnp-5337	10	16	,	,	PUNCT
fnp-5337	10	17	are	be	AUX
fnp-5337	10	18	more	more	ADV
fnp-5337	10	19	likely	likely	ADJ
fnp-5337	10	20	to	to	PART
fnp-5337	10	21	lead	lead	VERB
fnp-5337	10	22	to	to	ADP
fnp-5337	10	23	strong	strong	ADJ
fnp-5337	10	24	positive	positive	ADJ
fnp-5337	10	25	staining10	staining10	NOUN
fnp-5337	10	26	,	,	PUNCT
fnp-5337	10	27	while	while	SCONJ
fnp-5337	10	28	truncating	truncate	VERB
fnp-5337	10	29	mutations	mutation	NOUN
fnp-5337	10	30	(	(	PUNCT
fnp-5337	10	31	e.g.	e.g.	ADV
fnp-5337	10	32	,	,	PUNCT
fnp-5337	10	33	nonsense	nonsense	NOUN
fnp-5337	10	34	,	,	PUNCT
fnp-5337	10	35	splice	splice	NOUN
fnp-5337	10	36	site	site	NOUN
fnp-5337	10	37	,	,	PUNCT
fnp-5337	10	38	or	or	CCONJ
fnp-5337	10	39	frameshift	frameshift	NOUN
fnp-5337	10	40	)	)	PUNCT
fnp-5337	10	41	are	be	AUX
fnp-5337	10	42	associated	associate	VERB
fnp-5337	10	43	with	with	ADP
fnp-5337	10	44	absence	absence	NOUN
fnp-5337	10	45	or	or	CCONJ
fnp-5337	10	46	barely	barely	ADV
fnp-5337	10	47	detectable	detectable	ADJ
fnp-5337	10	48	p53	p53	NOUN
fnp-5337	10	49	protein	protein	NOUN
fnp-5337	10	50	immunopositivity	immunopositivity	NOUN
fnp-5337	10	51	(	(	PUNCT
fnp-5337	10	52	"	"	PUNCT
fnp-5337	10	53	null	null	ADJ
fnp-5337	10	54	phenotype")11	phenotype")11	PROPN
fnp-5337	10	55	.	.	PUNCT
fnp-5337	11	1	even	even	ADV
fnp-5337	11	2	among	among	ADP
fnp-5337	11	3	the	the	DET
fnp-5337	11	4	few	few	ADJ
fnp-5337	11	5	studies	study	NOUN
fnp-5337	11	6	that	that	PRON
fnp-5337	11	7	propose	propose	VERB
fnp-5337	11	8	p53	p53	NOUN
fnp-5337	11	9	staining	stain	VERB
fnp-5337	11	10	as	as	ADP
fnp-5337	11	11	a	a	DET
fnp-5337	11	12	practical	practical	ADJ
fnp-5337	11	13	prognostic	prognostic	ADJ
fnp-5337	11	14	marker	marker	NOUN
fnp-5337	11	15	,	,	PUNCT
fnp-5337	11	16	there	there	PRON
fnp-5337	11	17	is	be	VERB
fnp-5337	11	18	little	little	ADJ
fnp-5337	11	19	agreement	agreement	NOUN
fnp-5337	11	20	on	on	ADP
fnp-5337	11	21	the	the	DET
fnp-5337	11	22	optimal	optimal	ADJ
fnp-5337	11	23	cut	cut	NOUN
fnp-5337	11	24	-	-	PUNCT
fnp-5337	11	25	off	off	ADP
fnp-5337	11	26	value	value	NOUN
fnp-5337	11	27	.	.	PUNCT
fnp-5337	12	1	some	some	DET
fnp-5337	12	2	studies	study	NOUN
fnp-5337	12	3	presuming	presume	VERB
fnp-5337	12	4	tp53	tp53	PROPN
fnp-5337	12	5	mutations	mutation	NOUN
fnp-5337	12	6	based	base	VERB
fnp-5337	12	7	on	on	ADP
fnp-5337	12	8	p53	p53	NOUN
fnp-5337	12	9	immunostaining	immunostaining	NOUN
fnp-5337	12	10	simply	simply	ADV
fnp-5337	12	11	used	use	VERB
fnp-5337	12	12	"	"	PUNCT
fnp-5337	12	13	positive	positive	ADJ
fnp-5337	12	14	"	"	PUNCT
fnp-5337	12	15	staining	stain	VERB
fnp-5337	12	16	while	while	SCONJ
fnp-5337	12	17	others	other	NOUN
fnp-5337	12	18	did	do	AUX
fnp-5337	12	19	not	not	PART
fnp-5337	12	20	report	report	VERB
fnp-5337	12	21	definitions	definition	NOUN
fnp-5337	12	22	for	for	ADP
fnp-5337	12	23	p53	p53	NOUN
fnp-5337	12	24	positivity	positivity	NOUN
fnp-5337	12	25	,	,	PUNCT
fnp-5337	12	26	further	far	ADV
fnp-5337	12	27	confounding	confound	VERB
fnp-5337	12	28	the	the	DET
fnp-5337	12	29	literature11–13	literature11–13	NOUN
fnp-5337	12	30	.	.	PUNCT
fnp-5337	13	1	one	one	NUM
fnp-5337	13	2	of	of	ADP
fnp-5337	13	3	the	the	DET
fnp-5337	13	4	most	most	ADV
fnp-5337	13	5	recent	recent	ADJ
fnp-5337	13	6	comparative	comparative	ADJ
fnp-5337	13	7	studies	study	NOUN
fnp-5337	13	8	claimed	claim	VERB
fnp-5337	13	9	10	10	NUM
fnp-5337	13	10	 	 	SPACE
fnp-5337	13	11	%	%	NOUN
fnp-5337	13	12	positivity	positivity	NOUN
fnp-5337	13	13	as	as	ADP
fnp-5337	13	14	a	a	DET
fnp-5337	13	15	cut	cut	VERB
fnp-5337	13	16	-	-	PUNCT
fnp-5337	13	17	off	off	ADP
fnp-5337	13	18	point	point	NOUN
fnp-5337	13	19	to	to	PART
fnp-5337	13	20	predict	predict	VERB
fnp-5337	13	21	tp53	tp53	PROPN
fnp-5337	13	22	mutation	mutation	NOUN
fnp-5337	13	23	based	base	VERB
fnp-5337	13	24	on	on	ADP
fnp-5337	13	25	receiver	receiver	NOUN
fnp-5337	13	26	operating	operate	VERB
fnp-5337	13	27	characteristic	characteristic	ADJ
fnp-5337	13	28	curve	curve	NOUN
fnp-5337	13	29	(	(	PUNCT
fnp-5337	13	30	roc	roc	PROPN
fnp-5337	13	31	)	)	PUNCT
fnp-5337	13	32	analysis12	analysis12	PROPN
fnp-5337	13	33	,	,	PUNCT
fnp-5337	13	34	quoted	quote	VERB
fnp-5337	13	35	by	by	ADP
fnp-5337	13	36	the	the	DET
fnp-5337	13	37	who	who	PRON
fnp-5337	13	38	2021	2021	NUM
fnp-5337	13	39	classification4	classification4	VERB
fnp-5337	13	40	.	.	PUNCT
fnp-5337	13	41	to	to	PART
fnp-5337	13	42	determine	determine	VERB
fnp-5337	13	43	a	a	DET
fnp-5337	13	44	practical	practical	ADJ
fnp-5337	13	45	value	value	NOUN
fnp-5337	13	46	for	for	ADP
fnp-5337	13	47	p53	p53	NOUN
fnp-5337	13	48	immunostaining	immunostaining	NOUN
fnp-5337	13	49	in	in	ADP
fnp-5337	13	50	everyday	everyday	ADJ
fnp-5337	13	51	neuropathology	neuropathology	NOUN
fnp-5337	13	52	practice	practice	NOUN
fnp-5337	13	53	and	and	CCONJ
fnp-5337	13	54	to	to	PART
fnp-5337	13	55	validate	validate	VERB
fnp-5337	13	56	whether	whether	SCONJ
fnp-5337	13	57	a	a	DET
fnp-5337	13	58	10	10	NUM
fnp-5337	13	59	 	 	SPACE
fnp-5337	13	60	%	%	NOUN
fnp-5337	13	61	cut	cut	NOUN
fnp-5337	13	62	-	-	PUNCT
fnp-5337	13	63	off	off	NOUN
fnp-5337	13	64	can	can	AUX
fnp-5337	13	65	be	be	AUX
fnp-5337	13	66	reliably	reliably	ADV
fnp-5337	13	67	used	use	VERB
fnp-5337	13	68	to	to	PART
fnp-5337	13	69	suggest	suggest	VERB
fnp-5337	13	70	tp53	tp53	PROPN
fnp-5337	13	71	mutation	mutation	NOUN
fnp-5337	13	72	(	(	PUNCT
fnp-5337	13	73	as	as	SCONJ
fnp-5337	13	74	suggested	suggest	VERB
fnp-5337	13	75	by	by	ADP
fnp-5337	13	76	who	who	PRON
fnp-5337	13	77	2021	2021	NUM
fnp-5337	13	78	)	)	PUNCT
fnp-5337	13	79	,	,	PUNCT
fnp-5337	13	80	we	we	PRON
fnp-5337	13	81	analyzed	analyze	VERB
fnp-5337	13	82	a	a	DET
fnp-5337	13	83	group	group	NOUN
fnp-5337	13	84	of	of	ADP
fnp-5337	13	85	diffuse	diffuse	PROPN
fnp-5337	13	86	gliomas	glioma	NOUN
fnp-5337	13	87	for	for	ADP
fnp-5337	13	88	p53	p53	NOUN
fnp-5337	13	89	staining	staining	NOUN
fnp-5337	13	90	and	and	CCONJ
fnp-5337	13	91	tp53	tp53	PROPN
fnp-5337	13	92	mutations	mutation	NOUN
fnp-5337	13	93	.	.	PUNCT
fnp-5337	14	1	we	we	PRON
fnp-5337	14	2	identified	identify	VERB
fnp-5337	14	3	all	all	DET
fnp-5337	14	4	adult	adult	NOUN
fnp-5337	14	5	diffuse	diffuse	NOUN
fnp-5337	14	6	gliomas	glioma	NOUN
fnp-5337	14	7	and	and	CCONJ
fnp-5337	14	8	diffuse	diffuse	VERB
fnp-5337	14	9	midline	midline	NOUN
fnp-5337	14	10	gliomas	glioma	NOUN
fnp-5337	14	11	for	for	ADP
fnp-5337	14	12	which	which	PRON
fnp-5337	14	13	analysis	analysis	NOUN
fnp-5337	14	14	of	of	ADP
fnp-5337	14	15	p53	p53	NOUN
fnp-5337	14	16	immunohistochemistry	immunohistochemistry	NOUN
fnp-5337	14	17	and	and	CCONJ
fnp-5337	14	18	tp53	tp53	PROPN
fnp-5337	14	19	mutation	mutation	NOUN
fnp-5337	14	20	was	be	AUX
fnp-5337	14	21	performed	perform	VERB
fnp-5337	14	22	during	during	ADP
fnp-5337	14	23	a	a	DET
fnp-5337	14	24	five	five	NUM
fnp-5337	14	25	-	-	PUNCT
fnp-5337	14	26	year	year	NOUN
fnp-5337	14	27	period	period	NOUN
fnp-5337	14	28	.	.	PUNCT
fnp-5337	15	1	the	the	DET
fnp-5337	15	2	inclusion	inclusion	NOUN
fnp-5337	15	3	criteria	criterion	NOUN
fnp-5337	15	4	were	be	AUX
fnp-5337	15	5	:	:	PUNCT
fnp-5337	15	6	1	1	X
fnp-5337	15	7	)	)	PUNCT
fnp-5337	15	8	diagnosis	diagnosis	NOUN
fnp-5337	15	9	of	of	ADP
fnp-5337	15	10	adult	adult	NOUN
fnp-5337	15	11	diffuse	diffuse	NOUN
fnp-5337	15	12	glioma	glioma	NOUN
fnp-5337	15	13	or	or	CCONJ
fnp-5337	15	14	diffuse	diffuse	VERB
fnp-5337	15	15	midline	midline	NOUN
fnp-5337	15	16	glioma	glioma	NOUN
fnp-5337	15	17	between	between	ADP
fnp-5337	15	18	2015	2015	NUM
fnp-5337	15	19	and	and	CCONJ
fnp-5337	15	20	2020	2020	NUM
fnp-5337	15	21	,	,	PUNCT
fnp-5337	15	22	2	2	NUM
fnp-5337	15	23	)	)	PUNCT
fnp-5337	15	24	available	available	ADJ
fnp-5337	15	25	p53	p53	NOUN
fnp-5337	15	26	(	(	PUNCT
fnp-5337	15	27	do-7	do-7	X
fnp-5337	15	28	clone	clone	NOUN
fnp-5337	15	29	)	)	PUNCT
fnp-5337	15	30	immunohistochemistry	immunohistochemistry	NOUN
fnp-5337	15	31	staining	staining	NOUN
fnp-5337	15	32	,	,	PUNCT
fnp-5337	15	33	and	and	CCONJ
fnp-5337	15	34	3	3	X
fnp-5337	15	35	)	)	PUNCT
fnp-5337	15	36	available	available	ADJ
fnp-5337	15	37	analysis	analysis	NOUN
fnp-5337	15	38	with	with	ADP
fnp-5337	15	39	next	next	ADJ
fnp-5337	15	40	generation	generation	NOUN
fnp-5337	15	41	sequence	sequence	NOUN
fnp-5337	15	42	analysis	analysis	NOUN
fnp-5337	15	43	(	(	PUNCT
fnp-5337	15	44	ngs	ng	NOUN
fnp-5337	15	45	)	)	PUNCT
fnp-5337	15	46	,	,	PUNCT
fnp-5337	15	47	referred	refer	VERB
fnp-5337	15	48	to	to	ADP
fnp-5337	15	49	as	as	ADP
fnp-5337	15	50	"	"	PUNCT
fnp-5337	15	51	ucsf500	ucsf500	NUM
fnp-5337	15	52	ngs	ng	NOUN
fnp-5337	15	53	"	"	PUNCT
fnp-5337	15	54	panel14	panel14	NOUN
fnp-5337	15	55	,	,	PUNCT
fnp-5337	15	56	which	which	PRON
fnp-5337	15	57	includes	include	VERB
fnp-5337	15	58	a	a	DET
fnp-5337	15	59	comprehensive	comprehensive	ADJ
fnp-5337	15	60	assessment	assessment	NOUN
fnp-5337	15	61	of	of	ADP
fnp-5337	15	62	all	all	DET
fnp-5337	15	63	tp53	tp53	PROPN
fnp-5337	15	64	coding	code	VERB
fnp-5337	15	65	exons	exon	NOUN
fnp-5337	15	66	and	and	CCONJ
fnp-5337	15	67	most	most	ADJ
fnp-5337	15	68	other	other	ADJ
fnp-5337	15	69	genes	gene	NOUN
fnp-5337	15	70	known	know	VERB
fnp-5337	15	71	to	to	PART
fnp-5337	15	72	be	be	AUX
fnp-5337	15	73	recurrently	recurrently	ADV
fnp-5337	15	74	altered	alter	VERB
fnp-5337	15	75	in	in	ADP
fnp-5337	15	76	cns	cns	PROPN
fnp-5337	15	77	tumors15	tumors15	PROPN
fnp-5337	15	78	.	.	PUNCT
fnp-5337	16	1	clinical	clinical	ADJ
fnp-5337	16	2	and	and	CCONJ
fnp-5337	16	3	radiological	radiological	ADJ
fnp-5337	16	4	features	feature	NOUN
fnp-5337	16	5	were	be	AUX
fnp-5337	16	6	obtained	obtain	VERB
fnp-5337	16	7	from	from	ADP
fnp-5337	16	8	electronic	electronic	ADJ
fnp-5337	16	9	patient	patient	NOUN
fnp-5337	16	10	records	record	NOUN
fnp-5337	16	11	.	.	PUNCT
fnp-5337	17	1	all	all	DET
fnp-5337	17	2	cases	case	NOUN
fnp-5337	17	3	were	be	AUX
fnp-5337	17	4	re	re	VERB
fnp-5337	17	5	-	-	VERB
fnp-5337	17	6	analyzed	analyze	VERB
fnp-5337	17	7	for	for	ADP
fnp-5337	17	8	p53	p53	NOUN
fnp-5337	17	9	protein	protein	NOUN
fnp-5337	17	10	labeling	labeling	NOUN
fnp-5337	17	11	index	index	NOUN
fnp-5337	17	12	(	(	PUNCT
fnp-5337	17	13	li	li	PROPN
fnp-5337	17	14	)	)	PUNCT
fnp-5337	17	15	to	to	PART
fnp-5337	17	16	ensure	ensure	VERB
fnp-5337	17	17	uniform	uniform	ADJ
fnp-5337	17	18	assessment	assessment	NOUN
fnp-5337	17	19	based	base	VERB
fnp-5337	17	20	on	on	ADP
fnp-5337	17	21	strong	strong	ADJ
fnp-5337	17	22	nuclear	nuclear	ADJ
fnp-5337	17	23	staining	staining	NOUN
fnp-5337	17	24	(	(	PUNCT
fnp-5337	17	25	equal	equal	ADJ
fnp-5337	17	26	to	to	ADP
fnp-5337	17	27	or	or	CCONJ
fnp-5337	17	28	greater	great	ADJ
fnp-5337	17	29	than	than	ADP
fnp-5337	17	30	the	the	DET
fnp-5337	17	31	intensity	intensity	NOUN
fnp-5337	17	32	of	of	ADP
fnp-5337	17	33	positive	positive	ADJ
fnp-5337	17	34	control	control	NOUN
fnp-5337	17	35	tissue	tissue	NOUN
fnp-5337	17	36	)	)	PUNCT
fnp-5337	17	37	of	of	ADP
fnp-5337	17	38	p53	p53	NOUN
fnp-5337	17	39	protein	protein	NOUN
fnp-5337	17	40	in	in	ADP
fnp-5337	17	41	tumor	tumor	NOUN
fnp-5337	17	42	cells	cell	NOUN
fnp-5337	17	43	(	(	PUNCT
fnp-5337	17	44	figure	figure	NOUN
fnp-5337	17	45	1	1	NUM
fnp-5337	17	46	)	)	PUNCT
fnp-5337	17	47	.	.	PUNCT
fnp-5337	18	1	the	the	DET
fnp-5337	18	2	positive	positive	ADJ
fnp-5337	18	3	control	control	NOUN
fnp-5337	18	4	tissue	tissue	NOUN
fnp-5337	18	5	was	be	AUX
fnp-5337	18	6	validated	validate	VERB
fnp-5337	18	7	by	by	ADP
fnp-5337	18	8	ucsf500	ucsf500	PROPN
fnp-5337	18	9	ngs	ng	NOUN
fnp-5337	18	10	for	for	ADP
fnp-5337	18	11	tp53	tp53	PROPN
fnp-5337	18	12	mutation	mutation	NOUN
fnp-5337	18	13	at	at	ADP
fnp-5337	18	14	the	the	DET
fnp-5337	18	15	ucsf	ucsf	ADJ
fnp-5337	18	16	histology	histology	NOUN
fnp-5337	18	17	and	and	CCONJ
fnp-5337	18	18	clinical	clinical	ADJ
fnp-5337	18	19	cancer	cancer	NOUN
fnp-5337	18	20	genomics	genomic	NOUN
fnp-5337	18	21	laboratory	laboratory	NOUN
fnp-5337	18	22	.	.	PUNCT
fnp-5337	19	1	the	the	DET
fnp-5337	19	2	p53	p53	NOUN
fnp-5337	19	3	lis	li	NOUN
fnp-5337	19	4	were	be	AUX
fnp-5337	19	5	determined	determine	VERB
fnp-5337	19	6	by	by	ADP
fnp-5337	19	7	the	the	DET
fnp-5337	19	8	available	available	ADJ
fnp-5337	19	9	original	original	ADJ
fnp-5337	19	10	reported	report	VERB
fnp-5337	19	11	li	li	PROPN
fnp-5337	19	12	,	,	PUNCT
fnp-5337	19	13	which	which	PRON
fnp-5337	19	14	was	be	AUX
fnp-5337	19	15	achieved	achieve	VERB
fnp-5337	19	16	by	by	ADP
fnp-5337	19	17	capturing	capture	VERB
fnp-5337	19	18	a	a	DET
fnp-5337	19	19	digital	digital	ADJ
fnp-5337	19	20	image	image	NOUN
fnp-5337	19	21	of	of	ADP
fnp-5337	19	22	the	the	DET
fnp-5337	19	23	area	area	NOUN
fnp-5337	19	24	with	with	ADP
fnp-5337	19	25	highest	high	ADJ
fnp-5337	19	26	labeling	labeling	NOUN
fnp-5337	19	27	and	and	CCONJ
fnp-5337	19	28	counting	count	VERB
fnp-5337	19	29	at	at	ADV
fnp-5337	19	30	least	least	ADV
fnp-5337	19	31	500	500	NUM
fnp-5337	19	32	cells	cell	NOUN
fnp-5337	19	33	in	in	ADP
fnp-5337	19	34	the	the	DET
fnp-5337	19	35	captured	capture	VERB
fnp-5337	19	36	image	image	NOUN
fnp-5337	19	37	,	,	PUNCT
fnp-5337	19	38	followed	follow	VERB
fnp-5337	19	39	by	by	ADP
fnp-5337	19	40	the	the	DET
fnp-5337	19	41	re	re	NOUN
fnp-5337	19	42	-	-	NOUN
fnp-5337	19	43	assessment	assessment	NOUN
fnp-5337	19	44	of	of	ADP
fnp-5337	19	45	the	the	DET
fnp-5337	19	46	image	image	NOUN
fnp-5337	19	47	by	by	ADP
fnp-5337	19	48	two	two	NUM
fnp-5337	19	49	of	of	ADP
fnp-5337	19	50	the	the	DET
fnp-5337	19	51	authors	author	NOUN
fnp-5337	19	52	independently	independently	ADV
fnp-5337	19	53	to	to	PART
fnp-5337	19	54	estimate	estimate	VERB
fnp-5337	19	55	the	the	DET
fnp-5337	19	56	li	li	NOUN
fnp-5337	19	57	within	within	ADP
fnp-5337	19	58	a	a	DET
fnp-5337	19	59	5	5	NUM
fnp-5337	19	60	 	 	SPACE
fnp-5337	19	61	%	%	NOUN
fnp-5337	19	62	maximum	maximum	ADJ
fnp-5337	19	63	variance	variance	NOUN
fnp-5337	19	64	.	.	PUNCT
fnp-5337	20	1	genetic	genetic	ADJ
fnp-5337	20	2	alterations	alteration	NOUN
fnp-5337	20	3	involving	involve	VERB
fnp-5337	20	4	the	the	DET
fnp-5337	20	5	tumor	tumor	NOUN
fnp-5337	20	6	and	and	CCONJ
fnp-5337	20	7	germline	germline	NOUN
fnp-5337	20	8	were	be	AUX
fnp-5337	20	9	determined	determine	VERB
fnp-5337	20	10	as	as	ADP
fnp-5337	20	11	previously	previously	ADV
fnp-5337	20	12	described15,16	described15,16	ADJ
fnp-5337	20	13	.	.	PUNCT
fnp-5337	21	1	statistical	statistical	ADJ
fnp-5337	21	2	analyses	analysis	NOUN
fnp-5337	21	3	were	be	AUX
fnp-5337	21	4	performed	perform	VERB
fnp-5337	21	5	using	use	VERB
fnp-5337	21	6	r	r	NOUN
fnp-5337	21	7	version	version	NOUN
fnp-5337	21	8	4.2.2	4.2.2	NOUN
fnp-5337	21	9	.	.	PUNCT
fnp-5337	22	1	a	a	DET
fnp-5337	22	2	receiver	receiver	ADJ
fnp-5337	22	3	operator	operator	NOUN
fnp-5337	22	4	characteristic	characteristic	ADJ
fnp-5337	22	5	curve	curve	NOUN
fnp-5337	22	6	(	(	PUNCT
fnp-5337	22	7	roc	roc	PROPN
fnp-5337	22	8	)	)	PUNCT
fnp-5337	22	9	was	be	AUX
fnp-5337	22	10	analyzed	analyze	VERB
fnp-5337	22	11	using	use	VERB
fnp-5337	22	12	cutpointr	cutpointr	NOUN
fnp-5337	22	13	r	r	NOUN
fnp-5337	22	14	package	package	NOUN
fnp-5337	22	15	(	(	PUNCT
fnp-5337	22	16	version	version	NOUN
fnp-5337	22	17	1.1.1	1.1.1	NUM
fnp-5337	22	18	)	)	PUNCT
fnp-5337	22	19	.	.	PUNCT
fnp-5337	23	1	violin	violin	NOUN
fnp-5337	23	2	plot	plot	NOUN
fnp-5337	23	3	and	and	CCONJ
fnp-5337	23	4	pie	pie	NOUN
fnp-5337	23	5	chart	chart	NOUN
fnp-5337	23	6	were	be	AUX
fnp-5337	23	7	generated	generate	VERB
fnp-5337	23	8	using	use	VERB
fnp-5337	23	9	ggplot2	ggplot2	PROPN
fnp-5337	23	10	r	r	NOUN
fnp-5337	23	11	package	package	NOUN
fnp-5337	23	12	(	(	PUNCT
fnp-5337	23	13	version	version	NOUN
fnp-5337	23	14	3.3.5	3.3.5	NUM
fnp-5337	23	15	)	)	PUNCT
fnp-5337	23	16	.	.	PUNCT
fnp-5337	24	1	the	the	DET
fnp-5337	24	2	study	study	NOUN
fnp-5337	24	3	was	be	AUX
fnp-5337	24	4	approved	approve	VERB
fnp-5337	24	5	by	by	ADP
fnp-5337	24	6	ucsf	ucsf	PROPN
fnp-5337	24	7	committee	committee	PROPN
fnp-5337	24	8	for	for	ADP
fnp-5337	24	9	human	human	ADJ
fnp-5337	24	10	research	research	NOUN
fnp-5337	24	11	(	(	PUNCT
fnp-5337	24	12	ucsf	ucsf	PROPN
fnp-5337	24	13	chr	chr	PROPN
fnp-5337	24	14	10	10	NUM
fnp-5337	24	15	-	-	SYM
fnp-5337	24	16	01252	01252	NUM
fnp-5337	24	17	)	)	PUNCT
fnp-5337	24	18	.	.	PUNCT
fnp-5337	25	1	figure	figure	NOUN
fnp-5337	25	2	1	1	NUM
fnp-5337	25	3	.	.	PUNCT
fnp-5337	25	4	representative	representative	ADJ
fnp-5337	25	5	p53	p53	NOUN
fnp-5337	25	6	immunostaining	immunostaining	NOUN
fnp-5337	25	7	patterns	pattern	NOUN
fnp-5337	25	8	that	that	PRON
fnp-5337	25	9	were	be	AUX
fnp-5337	25	10	molecularly	molecularly	ADV
fnp-5337	25	11	confirmed	confirm	VERB
fnp-5337	25	12	as	as	ADP
fnp-5337	25	13	tp53	tp53	PROPN
fnp-5337	25	14	wildtype	wildtype	NOUN
fnp-5337	25	15	(	(	PUNCT
fnp-5337	25	16	a	a	NOUN
fnp-5337	25	17	)	)	PUNCT
fnp-5337	25	18	,	,	PUNCT
fnp-5337	25	19	tp53	tp53	PROPN
fnp-5337	25	20	frameshift	frameshift	NOUN
fnp-5337	25	21	mutation	mutation	NOUN
fnp-5337	25	22	(	(	PUNCT
fnp-5337	25	23	b	b	NOUN
fnp-5337	25	24	)	)	PUNCT
fnp-5337	25	25	and	and	CCONJ
fnp-5337	25	26	tp53	tp53	PROPN
fnp-5337	25	27	missense	missense	NOUN
fnp-5337	25	28	mutations	mutation	NOUN
fnp-5337	25	29	(	(	PUNCT
fnp-5337	25	30	c	c	NOUN
fnp-5337	25	31	and	and	CCONJ
fnp-5337	25	32	d	d	NOUN
fnp-5337	25	33	)	)	PUNCT
fnp-5337	25	34	.	.	PUNCT
fnp-5337	26	1	our	our	PRON
fnp-5337	26	2	study	study	NOUN
fnp-5337	26	3	group	group	NOUN
fnp-5337	26	4	was	be	AUX
fnp-5337	26	5	composed	compose	VERB
fnp-5337	26	6	of	of	ADP
fnp-5337	26	7	99	99	NUM
fnp-5337	26	8	patients	patient	NOUN
fnp-5337	26	9	with	with	ADP
fnp-5337	26	10	an	an	DET
fnp-5337	26	11	average	average	ADJ
fnp-5337	26	12	age	age	NOUN
fnp-5337	26	13	of	of	ADP
fnp-5337	26	14	44.5	44.5	NUM
fnp-5337	26	15	years	year	NOUN
fnp-5337	26	16	(	(	PUNCT
fnp-5337	26	17	range	range	NOUN
fnp-5337	26	18	1	1	NUM
fnp-5337	26	19	-	-	SYM
fnp-5337	26	20	81	81	NUM
fnp-5337	26	21	years	year	NOUN
fnp-5337	26	22	)	)	PUNCT
fnp-5337	26	23	.	.	PUNCT
fnp-5337	27	1	there	there	PRON
fnp-5337	27	2	were	be	VERB
fnp-5337	27	3	49	49	NUM
fnp-5337	27	4	female	female	ADJ
fnp-5337	27	5	and	and	CCONJ
fnp-5337	27	6	50	50	NUM
fnp-5337	27	7	male	male	ADJ
fnp-5337	27	8	patients	patient	NOUN
fnp-5337	27	9	.	.	PUNCT
fnp-5337	28	1	tumor	tumor	NOUN
fnp-5337	28	2	types	type	NOUN
fnp-5337	28	3	and	and	CCONJ
fnp-5337	28	4	locations	location	NOUN
fnp-5337	28	5	are	be	AUX
fnp-5337	28	6	presented	present	VERB
fnp-5337	28	7	in	in	ADP
fnp-5337	28	8	table	table	NOUN
fnp-5337	28	9	1	1	NUM
fnp-5337	28	10	.	.	PUNCT
fnp-5337	28	11	seventy	seventy	NUM
fnp-5337	28	12	-	-	PUNCT
fnp-5337	28	13	six	six	NUM
fnp-5337	28	14	(	(	PUNCT
fnp-5337	28	15	76	76	NUM
fnp-5337	28	16	)	)	PUNCT
fnp-5337	28	17	of	of	ADP
fnp-5337	28	18	the	the	DET
fnp-5337	28	19	samples	sample	NOUN
fnp-5337	28	20	were	be	AUX
fnp-5337	28	21	from	from	ADP
fnp-5337	28	22	primary	primary	ADJ
fnp-5337	28	23	tumors	tumor	NOUN
fnp-5337	28	24	(	(	PUNCT
fnp-5337	28	25	first	first	ADJ
fnp-5337	28	26	resection	resection	NOUN
fnp-5337	28	27	)	)	PUNCT
fnp-5337	28	28	while	while	SCONJ
fnp-5337	28	29	23	23	NUM
fnp-5337	28	30	were	be	AUX
fnp-5337	28	31	from	from	ADP
fnp-5337	28	32	recurrent	recurrent	ADJ
fnp-5337	28	33	tumors	tumor	NOUN
fnp-5337	28	34	.	.	PUNCT
fnp-5337	29	1	two	two	NUM
fnp-5337	29	2	glioblastomas	glioblastoma	NOUN
fnp-5337	29	3	had	have	VERB
fnp-5337	29	4	earlier	early	ADJ
fnp-5337	29	5	biopsies	biopsy	NOUN
fnp-5337	29	6	at	at	ADP
fnp-5337	29	7	another	another	DET
fnp-5337	29	8	hospital	hospital	NOUN
fnp-5337	29	9	without	without	ADP
fnp-5337	29	10	additional	additional	ADJ
fnp-5337	29	11	treatment	treatment	NOUN
fnp-5337	29	12	before	before	SCONJ
fnp-5337	29	13	the	the	DET
fnp-5337	29	14	patient	patient	NOUN
fnp-5337	29	15	was	be	AUX
fnp-5337	29	16	transferred	transfer	VERB
fnp-5337	29	17	to	to	ADP
fnp-5337	29	18	our	our	PRON
fnp-5337	29	19	institution	institution	NOUN
fnp-5337	29	20	.	.	PUNCT
fnp-5337	30	1	seventy	seventy	NUM
fnp-5337	30	2	-	-	PUNCT
fnp-5337	30	3	two	two	NUM
fnp-5337	30	4	(	(	PUNCT
fnp-5337	30	5	72	72	NUM
fnp-5337	30	6	)	)	PUNCT
fnp-5337	30	7	of	of	ADP
fnp-5337	30	8	the	the	DET
fnp-5337	30	9	primary	primary	ADJ
fnp-5337	30	10	tumors	tumor	NOUN
fnp-5337	30	11	were	be	AUX
fnp-5337	30	12	cns	cns	PROPN
fnp-5337	30	13	who	who	PRON
fnp-5337	30	14	grade	grade	VERB
fnp-5337	30	15	4	4	NUM
fnp-5337	30	16	,	,	PUNCT
fnp-5337	30	17	six	six	NUM
fnp-5337	30	18	were	be	AUX
fnp-5337	30	19	cns	cns	NOUN
fnp-5337	30	20	who	who	PRON
fnp-5337	30	21	grade	grade	VERB
fnp-5337	30	22	3	3	NUM
fnp-5337	30	23	,	,	PUNCT
fnp-5337	30	24	and	and	CCONJ
fnp-5337	30	25	twenty	twenty	NUM
fnp-5337	30	26	-	-	PUNCT
fnp-5337	30	27	one	one	NUM
fnp-5337	30	28	tumors	tumor	NOUN
fnp-5337	30	29	were	be	AUX
fnp-5337	30	30	cns	cns	PROPN
fnp-5337	30	31	who	who	PRON
fnp-5337	30	32	grade	grade	NOUN
fnp-5337	30	33	2	2	NUM
fnp-5337	30	34	.	.	PUNCT
fnp-5337	31	1	there	there	PRON
fnp-5337	31	2	were	be	VERB
fnp-5337	31	3	52	52	NUM
fnp-5337	31	4	tp53	tp53	PROPN
fnp-5337	31	5	-	-	PUNCT
fnp-5337	31	6	mutant	mutant	NOUN
fnp-5337	31	7	and	and	CCONJ
fnp-5337	31	8	47	47	NUM
fnp-5337	31	9	tp53	tp53	PROPN
fnp-5337	31	10	-	-	PUNCT
fnp-5337	31	11	wildtype	wildtype	NOUN
fnp-5337	31	12	tumors	tumor	NOUN
fnp-5337	31	13	and	and	CCONJ
fnp-5337	31	14	the	the	DET
fnp-5337	31	15	distribution	distribution	NOUN
fnp-5337	31	16	of	of	ADP
fnp-5337	31	17	these	these	DET
fnp-5337	31	18	mutations	mutation	NOUN
fnp-5337	31	19	among	among	ADP
fnp-5337	31	20	tumor	tumor	NOUN
fnp-5337	31	21	types	type	NOUN
fnp-5337	31	22	is	be	AUX
fnp-5337	31	23	presented	present	VERB
fnp-5337	31	24	in	in	ADP
fnp-5337	31	25	table	table	NOUN
fnp-5337	31	26	1	1	NUM
fnp-5337	31	27	.	.	PUNCT
fnp-5337	31	28	forty	forty	NUM
fnp-5337	31	29	-	-	PUNCT
fnp-5337	31	30	two	two	NUM
fnp-5337	31	31	(	(	PUNCT
fnp-5337	31	32	42	42	NUM
fnp-5337	31	33	)	)	PUNCT
fnp-5337	31	34	tumors	tumor	NOUN
fnp-5337	31	35	had	have	VERB
fnp-5337	31	36	missense	missense	NOUN
fnp-5337	31	37	mutations	mutation	NOUN
fnp-5337	31	38	,	,	PUNCT
fnp-5337	31	39	while	while	SCONJ
fnp-5337	31	40	three	three	NUM
fnp-5337	31	41	others	other	NOUN
fnp-5337	31	42	had	have	VERB
fnp-5337	31	43	missense	missense	NOUN
fnp-5337	31	44	combined	combine	VERB
fnp-5337	31	45	with	with	ADP
fnp-5337	31	46	frameshift	frameshift	ADJ
fnp-5337	31	47	mutations	mutation	NOUN
fnp-5337	31	48	.	.	PUNCT
fnp-5337	32	1	there	there	PRON
fnp-5337	32	2	were	be	VERB
fnp-5337	32	3	3	3	NUM
fnp-5337	32	4	tumors	tumor	NOUN
fnp-5337	32	5	with	with	ADP
fnp-5337	32	6	frameshift	frameshift	ADJ
fnp-5337	32	7	mutation	mutation	NOUN
fnp-5337	32	8	-	-	PUNCT
fnp-5337	32	9	only	only	ADV
fnp-5337	32	10	(	(	PUNCT
fnp-5337	32	11	figure	figure	NOUN
fnp-5337	32	12	2b	2b	NOUN
fnp-5337	32	13	)	)	PUNCT
fnp-5337	32	14	.	.	PUNCT
fnp-5337	33	1	table	table	NOUN
fnp-5337	33	2	1	1	NUM
fnp-5337	33	3	.	.	PUNCT
fnp-5337	34	1	demographics	demographic	NOUN
fnp-5337	34	2	,	,	PUNCT
fnp-5337	34	3	location	location	NOUN
fnp-5337	34	4	of	of	ADP
fnp-5337	34	5	tumor	tumor	NOUN
fnp-5337	34	6	,	,	PUNCT
fnp-5337	34	7	and	and	CCONJ
fnp-5337	34	8	final	final	ADJ
fnp-5337	34	9	diagnosis	diagnosis	NOUN
fnp-5337	34	10	    	    	SPACE
fnp-5337	34	11	overall	overall	ADJ
fnp-5337	34	12	tp53	tp53	PROPN
fnp-5337	34	13	wildtype	wildtype	NOUN
fnp-5337	34	14	tp53	tp53	PROPN
fnp-5337	34	15	mutant	mutant	NOUN
fnp-5337	34	16	p	p	NOUN
fnp-5337	34	17	n	n	PRON
fnp-5337	34	18	  	  	SPACE
fnp-5337	34	19	99	99	NUM
fnp-5337	34	20	47	47	NUM
fnp-5337	34	21	52	52	NUM
fnp-5337	34	22	  	  	SPACE
fnp-5337	34	23	age	age	NOUN
fnp-5337	34	24	,	,	PUNCT
fnp-5337	34	25	years	year	NOUN
fnp-5337	34	26	(	(	PUNCT
fnp-5337	34	27	mean	mean	VERB
fnp-5337	34	28	(	(	PUNCT
fnp-5337	34	29	so	so	ADV
fnp-5337	34	30	)	)	PUNCT
fnp-5337	34	31	)	)	PUNCT
fnp-5337	34	32	  	  	SPACE
fnp-5337	34	33	44.5	44.5	NUM
fnp-5337	34	34	(	(	PUNCT
fnp-5337	34	35	19.1	19.1	NUM
fnp-5337	34	36	)	)	PUNCT
fnp-5337	34	37	51.5	51.5	NUM
fnp-5337	34	38	(	(	PUNCT
fnp-5337	34	39	18.6	18.6	NUM
fnp-5337	34	40	)	)	PUNCT
fnp-5337	34	41	38.2	38.2	NUM
fnp-5337	34	42	(	(	PUNCT
fnp-5337	34	43	17.4	17.4	NUM
fnp-5337	34	44	)	)	PUNCT
fnp-5337	34	45	<	<	X
fnp-5337	34	46	0.001	0.001	NUM
fnp-5337	34	47	gender	gender	NOUN
fnp-5337	34	48	(	(	PUNCT
fnp-5337	34	49	%	%	NOUN
fnp-5337	34	50	)	)	PUNCT
fnp-5337	34	51	female	female	NOUN
fnp-5337	34	52	49	49	NUM
fnp-5337	34	53	(	(	PUNCT
fnp-5337	34	54	49.5	49.5	NUM
fnp-5337	34	55	)	)	SYM
fnp-5337	34	56	28	28	NUM
fnp-5337	34	57	(	(	PUNCT
fnp-5337	34	58	59.6	59.6	NUM
fnp-5337	34	59	)	)	SYM
fnp-5337	34	60	21	21	NUM
fnp-5337	34	61	(	(	PUNCT
fnp-5337	34	62	40.4	40.4	NUM
fnp-5337	34	63	)	)	PUNCT
fnp-5337	34	64	0.088	0.088	NUM
fnp-5337	34	65	  	  	SPACE
fnp-5337	34	66	male	male	ADJ
fnp-5337	34	67	50	50	NUM
fnp-5337	34	68	(	(	PUNCT
fnp-5337	34	69	50.5	50.5	NUM
fnp-5337	34	70	)	)	SYM
fnp-5337	34	71	19	19	NUM
fnp-5337	34	72	(	(	PUNCT
fnp-5337	34	73	40.4	40.4	NUM
fnp-5337	34	74	)	)	PUNCT
fnp-5337	34	75	31	31	NUM
fnp-5337	34	76	(	(	PUNCT
fnp-5337	34	77	59.6	59.6	NUM
fnp-5337	34	78	)	)	PUNCT
fnp-5337	34	79	  	  	SPACE
fnp-5337	34	80	site	site	NOUN
fnp-5337	34	81	(	(	PUNCT
fnp-5337	34	82	%	%	INTJ
fnp-5337	34	83	)	)	PUNCT
fnp-5337	34	84	brainstem	brainstem	NOUN
fnp-5337	34	85	3	3	NUM
fnp-5337	34	86	(	(	PUNCT
fnp-5337	34	87	3.0	3.0	NUM
fnp-5337	34	88	)	)	SYM
fnp-5337	34	89	1	1	NUM
fnp-5337	34	90	(	(	PUNCT
fnp-5337	34	91	2.1	2.1	NUM
fnp-5337	34	92	)	)	SYM
fnp-5337	34	93	2	2	NUM
fnp-5337	34	94	(	(	PUNCT
fnp-5337	34	95	3.8	3.8	NUM
fnp-5337	34	96	)	)	PUNCT
fnp-5337	34	97	0.359	0.359	NUM
fnp-5337	34	98	  	  	SPACE
fnp-5337	34	99	frontal	frontal	ADJ
fnp-5337	34	100	41	41	NUM
fnp-5337	34	101	(	(	PUNCT
fnp-5337	34	102	41.4	41.4	NUM
fnp-5337	34	103	)	)	PUNCT
fnp-5337	34	104	15	15	NUM
fnp-5337	34	105	(	(	PUNCT
fnp-5337	34	106	31.9	31.9	NUM
fnp-5337	34	107	)	)	PUNCT
fnp-5337	34	108	26	26	NUM
fnp-5337	34	109	(	(	PUNCT
fnp-5337	34	110	50.0	50.0	NUM
fnp-5337	34	111	)	)	PUNCT
fnp-5337	34	112	    	    	SPACE
fnp-5337	34	113	occipital	occipital	NOUN
fnp-5337	34	114	3	3	NUM
fnp-5337	34	115	(	(	PUNCT
fnp-5337	34	116	3.0	3.0	NUM
fnp-5337	34	117	)	)	SYM
fnp-5337	34	118	2	2	NUM
fnp-5337	34	119	(	(	PUNCT
fnp-5337	34	120	4.3	4.3	NUM
fnp-5337	34	121	)	)	SYM
fnp-5337	34	122	1	1	NUM
fnp-5337	34	123	(	(	PUNCT
fnp-5337	34	124	1.9	1.9	NUM
fnp-5337	34	125	)	)	PUNCT
fnp-5337	34	126	    	    	SPACE
fnp-5337	34	127	parietal	parietal	ADJ
fnp-5337	34	128	18	18	NUM
fnp-5337	34	129	(	(	PUNCT
fnp-5337	34	130	18.2	18.2	NUM
fnp-5337	34	131	)	)	PUNCT
fnp-5337	34	132	8	8	NUM
fnp-5337	34	133	(	(	PUNCT
fnp-5337	34	134	17.0	17.0	NUM
fnp-5337	34	135	)	)	PUNCT
fnp-5337	34	136	10	10	NUM
fnp-5337	34	137	(	(	PUNCT
fnp-5337	34	138	19.2	19.2	NUM
fnp-5337	34	139	)	)	PUNCT
fnp-5337	34	140	    	    	SPACE
fnp-5337	34	141	temporal	temporal	ADJ
fnp-5337	34	142	29	29	NUM
fnp-5337	34	143	(	(	PUNCT
fnp-5337	34	144	29.3	29.3	NUM
fnp-5337	34	145	)	)	SYM
fnp-5337	34	146	18	18	NUM
fnp-5337	34	147	(	(	PUNCT
fnp-5337	34	148	38.3	38.3	NUM
fnp-5337	34	149	)	)	PUNCT
fnp-5337	34	150	11	11	NUM
fnp-5337	34	151	(	(	PUNCT
fnp-5337	34	152	21.2	21.2	NUM
fnp-5337	34	153	)	)	PUNCT
fnp-5337	34	154	    	    	SPACE
fnp-5337	34	155	thalamic	thalamic	ADJ
fnp-5337	34	156	5	5	NUM
fnp-5337	34	157	(	(	PUNCT
fnp-5337	34	158	5.1	5.1	NUM
fnp-5337	34	159	)	)	PUNCT
fnp-5337	34	160	3	3	NUM
fnp-5337	34	161	(	(	PUNCT
fnp-5337	34	162	6.4	6.4	NUM
fnp-5337	34	163	)	)	SYM
fnp-5337	34	164	2	2	NUM
fnp-5337	34	165	(	(	PUNCT
fnp-5337	34	166	3.8	3.8	NUM
fnp-5337	34	167	)	)	PUNCT
fnp-5337	34	168	  	  	SPACE
fnp-5337	34	169	final	final	ADJ
fnp-5337	34	170	integrated	integrated	ADJ
fnp-5337	34	171	diagnosis	diagnosis	NOUN
fnp-5337	34	172	(	(	PUNCT
fnp-5337	34	173	%	%	INTJ
fnp-5337	34	174	)	)	PUNCT
fnp-5337	34	175	astrocytoma	astrocytoma	NOUN
fnp-5337	34	176	,	,	PUNCT
fnp-5337	34	177	idh	idh	NOUN
fnp-5337	34	178	-	-	PUNCT
fnp-5337	34	179	mutant	mutant	NOUN
fnp-5337	34	180	,	,	PUNCT
fnp-5337	34	181	cns	cns	PROPN
fnp-5337	34	182	who	who	PRON
fnp-5337	34	183	grade	grade	VERB
fnp-5337	34	184	2	2	NUM
fnp-5337	34	185	11	11	NUM
fnp-5337	34	186	(	(	PUNCT
fnp-5337	34	187	11.1	11.1	NUM
fnp-5337	34	188	)	)	PUNCT
fnp-5337	34	189	0	0	NUM
fnp-5337	35	1	(	(	PUNCT
fnp-5337	35	2	0.0	0.0	NUM
fnp-5337	35	3	)	)	PUNCT
fnp-5337	35	4	11	11	NUM
fnp-5337	35	5	(	(	PUNCT
fnp-5337	35	6	21.2	21.2	NUM
fnp-5337	35	7	)	)	PUNCT
fnp-5337	36	1	<	<	X
fnp-5337	36	2	0.001	0.001	NUM
fnp-5337	36	3	  	  	SPACE
fnp-5337	36	4	astrocytoma	astrocytoma	NOUN
fnp-5337	36	5	,	,	PUNCT
fnp-5337	36	6	idh	idh	NOUN
fnp-5337	36	7	-	-	PUNCT
fnp-5337	36	8	mutant	mutant	NOUN
fnp-5337	36	9	,	,	PUNCT
fnp-5337	36	10	cns	cns	PROPN
fnp-5337	36	11	who	who	PRON
fnp-5337	36	12	grade	grade	VERB
fnp-5337	36	13	3	3	NUM
fnp-5337	36	14	6	6	NUM
fnp-5337	36	15	(	(	PUNCT
fnp-5337	36	16	6.1	6.1	NUM
fnp-5337	36	17	)	)	PUNCT
fnp-5337	36	18	0	0	NUM
fnp-5337	37	1	(	(	PUNCT
fnp-5337	37	2	0.0	0.0	NUM
fnp-5337	37	3	)	)	PUNCT
fnp-5337	37	4	6	6	NUM
fnp-5337	37	5	(	(	PUNCT
fnp-5337	37	6	11.5	11.5	NUM
fnp-5337	37	7	)	)	PUNCT
fnp-5337	37	8	    	    	SPACE
fnp-5337	37	9	astrocytoma	astrocytoma	NOUN
fnp-5337	37	10	,	,	PUNCT
fnp-5337	37	11	idh	idh	NOUN
fnp-5337	37	12	-	-	PUNCT
fnp-5337	37	13	mutant	mutant	NOUN
fnp-5337	37	14	,	,	PUNCT
fnp-5337	37	15	cns	cns	PROPN
fnp-5337	37	16	who	who	PRON
fnp-5337	37	17	grade	grade	VERB
fnp-5337	37	18	4	4	NUM
fnp-5337	37	19	8	8	NUM
fnp-5337	37	20	(	(	PUNCT
fnp-5337	37	21	8.1	8.1	NUM
fnp-5337	37	22	)	)	PUNCT
fnp-5337	37	23	0	0	NUM
fnp-5337	37	24	(	(	PUNCT
fnp-5337	37	25	0.0	0.0	NUM
fnp-5337	37	26	)	)	PUNCT
fnp-5337	37	27	8	8	NUM
fnp-5337	37	28	(	(	PUNCT
fnp-5337	37	29	15.4	15.4	NUM
fnp-5337	37	30	)	)	PUNCT
fnp-5337	37	31	    	    	SPACE
fnp-5337	37	32	diffuse	diffuse	VERB
fnp-5337	37	33	midline	midline	NOUN
fnp-5337	37	34	glioma	glioma	NOUN
fnp-5337	37	35	,	,	PUNCT
fnp-5337	37	36	h3	h3	VERB
fnp-5337	37	37	k27m	k27m	NOUN
fnp-5337	37	38	-	-	NOUN
fnp-5337	37	39	mutant	mutant	ADJ
fnp-5337	37	40	,	,	PUNCT
fnp-5337	37	41	cns	cns	PROPN
fnp-5337	37	42	who	who	PRON
fnp-5337	37	43	grade	grade	VERB
fnp-5337	37	44	4	4	NUM
fnp-5337	37	45	4	4	NUM
fnp-5337	37	46	(	(	PUNCT
fnp-5337	37	47	4.0	4.0	NUM
fnp-5337	37	48	)	)	SYM
fnp-5337	37	49	2	2	NUM
fnp-5337	37	50	(	(	PUNCT
fnp-5337	37	51	4.3	4.3	NUM
fnp-5337	37	52	)	)	SYM
fnp-5337	37	53	2	2	NUM
fnp-5337	37	54	(	(	PUNCT
fnp-5337	37	55	3.8	3.8	NUM
fnp-5337	37	56	)	)	PUNCT
fnp-5337	37	57	    	    	SPACE
fnp-5337	37	58	glioblastoma	glioblastoma	NOUN
fnp-5337	37	59	,	,	PUNCT
fnp-5337	37	60	idh	idh	NOUN
fnp-5337	37	61	-	-	PUNCT
fnp-5337	37	62	wildtype	wildtype	NOUN
fnp-5337	37	63	,	,	PUNCT
fnp-5337	37	64	cns	cns	PROPN
fnp-5337	37	65	who	who	PRON
fnp-5337	37	66	grade	grade	VERB
fnp-5337	37	67	4	4	NUM
fnp-5337	37	68	60	60	NUM
fnp-5337	37	69	(	(	PUNCT
fnp-5337	37	70	60.6	60.6	NUM
fnp-5337	37	71	)	)	PUNCT
fnp-5337	37	72	37	37	NUM
fnp-5337	37	73	(	(	PUNCT
fnp-5337	37	74	78.7	78.7	NUM
fnp-5337	37	75	)	)	PUNCT
fnp-5337	37	76	23	23	NUM
fnp-5337	37	77	(	(	PUNCT
fnp-5337	37	78	44.2	44.2	NUM
fnp-5337	37	79	)	)	PUNCT
fnp-5337	37	80	    	    	SPACE
fnp-5337	37	81	oligodendroglioma	oligodendroglioma	VERB
fnp-5337	37	82	,	,	PUNCT
fnp-5337	37	83	idh	idh	NOUN
fnp-5337	37	84	-	-	PUNCT
fnp-5337	37	85	mutant	mutant	NOUN
fnp-5337	37	86	and	and	CCONJ
fnp-5337	37	87	1p/19q	1p/19q	NOUN
fnp-5337	37	88	-	-	PUNCT
fnp-5337	37	89	codeleted	codelete	VERB
fnp-5337	37	90	,	,	PUNCT
fnp-5337	37	91	cns	cns	PROPN
fnp-5337	37	92	who	who	PRON
fnp-5337	37	93	grade	grade	VERB
fnp-5337	37	94	2	2	NUM
fnp-5337	37	95	10	10	NUM
fnp-5337	37	96	(	(	PUNCT
fnp-5337	37	97	10.1	10.1	NUM
fnp-5337	37	98	)	)	PUNCT
fnp-5337	37	99	8	8	NUM
fnp-5337	37	100	(	(	PUNCT
fnp-5337	37	101	17.0	17.0	NUM
fnp-5337	37	102	)	)	PUNCT
fnp-5337	37	103	2	2	NUM
fnp-5337	37	104	(	(	PUNCT
fnp-5337	37	105	3.8	3.8	NUM
fnp-5337	37	106	)	)	PUNCT
fnp-5337	37	107	the	the	DET
fnp-5337	37	108	median	median	ADJ
fnp-5337	37	109	p53	p53	NOUN
fnp-5337	37	110	immunohistochemistry	immunohistochemistry	NOUN
fnp-5337	37	111	labeling	labeling	NOUN
fnp-5337	37	112	index	index	NOUN
fnp-5337	37	113	for	for	ADP
fnp-5337	37	114	tumors	tumor	NOUN
fnp-5337	37	115	harboring	harbor	VERB
fnp-5337	37	116	tp53	tp53	PROPN
fnp-5337	37	117	mutation	mutation	NOUN
fnp-5337	37	118	was	be	AUX
fnp-5337	37	119	60	60	NUM
fnp-5337	37	120	 	 	SPACE
fnp-5337	37	121	%	%	NOUN
fnp-5337	37	122	(	(	PUNCT
fnp-5337	37	123	range	range	NOUN
fnp-5337	37	124	:	:	PUNCT
fnp-5337	37	125	0	0	NUM
fnp-5337	37	126	-	-	SYM
fnp-5337	37	127	95	95	NUM
fnp-5337	37	128	 	 	SPACE
fnp-5337	37	129	%	%	NOUN
fnp-5337	37	130	)	)	PUNCT
fnp-5337	37	131	with	with	ADP
fnp-5337	37	132	an	an	DET
fnp-5337	37	133	interquartile	interquartile	ADJ
fnp-5337	37	134	range	range	NOUN
fnp-5337	37	135	(	(	PUNCT
fnp-5337	37	136	iqr	iqr	NOUN
fnp-5337	37	137	)	)	PUNCT
fnp-5337	37	138	of	of	ADP
fnp-5337	37	139	66.25	66.25	NUM
fnp-5337	37	140	 	 	SPACE
fnp-5337	37	141	%	%	NOUN
fnp-5337	37	142	,	,	PUNCT
fnp-5337	37	143	while	while	SCONJ
fnp-5337	37	144	the	the	DET
fnp-5337	37	145	median	median	ADJ
fnp-5337	37	146	value	value	NOUN
fnp-5337	37	147	for	for	ADP
fnp-5337	37	148	those	those	PRON
fnp-5337	37	149	without	without	ADP
fnp-5337	37	150	tp53	tp53	PROPN
fnp-5337	37	151	mutations	mutation	NOUN
fnp-5337	37	152	was	be	AUX
fnp-5337	37	153	10	10	NUM
fnp-5337	37	154	 	 	SPACE
fnp-5337	37	155	%	%	NOUN
fnp-5337	37	156	with	with	ADP
fnp-5337	37	157	an	an	DET
fnp-5337	37	158	iqr	iqr	NOUN
fnp-5337	37	159	of	of	ADP
fnp-5337	37	160	10.5	10.5	NUM
fnp-5337	37	161	 	 	SPACE
fnp-5337	37	162	%	%	NOUN
fnp-5337	37	163	(	(	PUNCT
fnp-5337	37	164	range	range	NOUN
fnp-5337	37	165	:	:	PUNCT
fnp-5337	37	166	0	0	NUM
fnp-5337	37	167	-	-	SYM
fnp-5337	37	168	30	30	NUM
fnp-5337	37	169	 	 	SPACE
fnp-5337	37	170	%	%	NOUN
fnp-5337	37	171	)	)	PUNCT
fnp-5337	37	172	.	.	PUNCT
fnp-5337	38	1	when	when	SCONJ
fnp-5337	38	2	42	42	NUM
fnp-5337	38	3	tumors	tumor	NOUN
fnp-5337	38	4	with	with	ADP
fnp-5337	38	5	missense	missense	NOUN
fnp-5337	38	6	mutations	mutation	NOUN
fnp-5337	38	7	were	be	AUX
fnp-5337	38	8	considered	consider	VERB
fnp-5337	38	9	,	,	PUNCT
fnp-5337	38	10	the	the	DET
fnp-5337	38	11	median	median	ADJ
fnp-5337	38	12	labeling	labeling	NOUN
fnp-5337	38	13	index	index	NOUN
fnp-5337	38	14	was	be	AUX
fnp-5337	38	15	calculated	calculate	VERB
fnp-5337	38	16	as	as	ADP
fnp-5337	38	17	77.5	77.5	NUM
fnp-5337	38	18	 	 	SPACE
fnp-5337	38	19	%	%	NOUN
fnp-5337	38	20	(	(	PUNCT
fnp-5337	38	21	mean	mean	NOUN
fnp-5337	38	22	64.24	64.24	NUM
fnp-5337	38	23	 	 	SPACE
fnp-5337	38	24	%	%	NOUN
fnp-5337	38	25	)	)	PUNCT
fnp-5337	38	26	,	,	PUNCT
fnp-5337	38	27	and	and	CCONJ
fnp-5337	38	28	the	the	DET
fnp-5337	38	29	median	median	ADJ
fnp-5337	38	30	labeling	labeling	NOUN
fnp-5337	38	31	index	index	NOUN
fnp-5337	38	32	for	for	ADP
fnp-5337	38	33	cases	case	NOUN
fnp-5337	38	34	with	with	ADP
fnp-5337	38	35	frameshift	frameshift	ADJ
fnp-5337	38	36	mutations	mutation	NOUN
fnp-5337	38	37	was	be	AUX
fnp-5337	38	38	12.5	12.5	NUM
fnp-5337	38	39	 	 	SPACE
fnp-5337	38	40	%	%	NOUN
fnp-5337	38	41	(	(	PUNCT
fnp-5337	38	42	mean	mean	NOUN
fnp-5337	38	43	21	21	NUM
fnp-5337	38	44	 	 	SPACE
fnp-5337	38	45	%	%	NOUN
fnp-5337	38	46	)	)	PUNCT
fnp-5337	38	47	.	.	PUNCT
fnp-5337	39	1	however	however	ADV
fnp-5337	39	2	,	,	PUNCT
fnp-5337	39	3	there	there	PRON
fnp-5337	39	4	was	be	VERB
fnp-5337	39	5	a	a	DET
fnp-5337	39	6	wide	wide	ADJ
fnp-5337	39	7	range	range	NOUN
fnp-5337	39	8	of	of	ADP
fnp-5337	39	9	labeling	labeling	NOUN
fnp-5337	39	10	indices	index	NOUN
fnp-5337	39	11	for	for	ADP
fnp-5337	39	12	missense	missense	NOUN
fnp-5337	39	13	(	(	PUNCT
fnp-5337	39	14	1	1	NUM
fnp-5337	39	15	-	-	SYM
fnp-5337	39	16	95	95	NUM
fnp-5337	39	17	 	 	SPACE
fnp-5337	39	18	%	%	NOUN
fnp-5337	39	19	)	)	PUNCT
fnp-5337	39	20	mutations	mutation	NOUN
fnp-5337	39	21	.	.	PUNCT
fnp-5337	40	1	of	of	ADP
fnp-5337	40	2	note	note	NOUN
fnp-5337	40	3	,	,	PUNCT
fnp-5337	40	4	out	out	ADP
fnp-5337	40	5	of	of	ADP
fnp-5337	40	6	11	11	NUM
fnp-5337	40	7	tumors	tumor	NOUN
fnp-5337	40	8	with	with	ADP
fnp-5337	40	9	absent	absent	ADJ
fnp-5337	40	10	p53	p53	NOUN
fnp-5337	40	11	staining	staining	NOUN
fnp-5337	40	12	,	,	PUNCT
fnp-5337	40	13	6	6	NUM
fnp-5337	40	14	had	have	VERB
fnp-5337	40	15	tp53	tp53	PROPN
fnp-5337	40	16	mutations	mutation	NOUN
fnp-5337	40	17	(	(	PUNCT
fnp-5337	40	18	two	two	NUM
fnp-5337	40	19	frameshift	frameshift	NOUN
fnp-5337	40	20	,	,	PUNCT
fnp-5337	40	21	two	two	NUM
fnp-5337	40	22	missense	missense	NOUN
fnp-5337	40	23	,	,	PUNCT
fnp-5337	40	24	one	one	NUM
fnp-5337	40	25	splice	splice	NOUN
fnp-5337	40	26	site	site	NOUN
fnp-5337	40	27	mutation	mutation	NOUN
fnp-5337	40	28	,	,	PUNCT
fnp-5337	40	29	and	and	CCONJ
fnp-5337	40	30	one	one	NUM
fnp-5337	40	31	structural	structural	ADJ
fnp-5337	40	32	variant	variant	NOUN
fnp-5337	40	33	)	)	PUNCT
fnp-5337	40	34	.	.	PUNCT
fnp-5337	41	1	figure	figure	NOUN
fnp-5337	41	2	2	2	NUM
fnp-5337	41	3	.	.	PUNCT
fnp-5337	41	4	labeling	labeling	NOUN
fnp-5337	41	5	index	index	NOUN
fnp-5337	41	6	of	of	ADP
fnp-5337	41	7	p53	p53	NOUN
fnp-5337	41	8	is	be	AUX
fnp-5337	41	9	significantly	significantly	ADV
fnp-5337	41	10	higher	high	ADJ
fnp-5337	41	11	in	in	ADP
fnp-5337	41	12	tp53	tp53	PROPN
fnp-5337	41	13	-	-	PUNCT
fnp-5337	41	14	mutated	mutate	VERB
fnp-5337	41	15	group	group	NOUN
fnp-5337	41	16	as	as	SCONJ
fnp-5337	41	17	shown	show	VERB
fnp-5337	41	18	in	in	ADP
fnp-5337	41	19	the	the	DET
fnp-5337	41	20	violin	violin	NOUN
fnp-5337	41	21	plot	plot	NOUN
fnp-5337	41	22	(	(	PUNCT
fnp-5337	41	23	a	a	NOUN
fnp-5337	41	24	)	)	PUNCT
fnp-5337	41	25	.	.	PUNCT
fnp-5337	42	1	radar	radar	NOUN
fnp-5337	42	2	chart	chart	NOUN
fnp-5337	42	3	for	for	ADP
fnp-5337	42	4	tp53	tp53	PROPN
fnp-5337	42	5	mutation	mutation	NOUN
fnp-5337	42	6	types	type	NOUN
fnp-5337	42	7	in	in	ADP
fnp-5337	42	8	tumor	tumor	NOUN
fnp-5337	42	9	with	with	ADP
fnp-5337	42	10	high	high	ADJ
fnp-5337	42	11	p53	p53	NOUN
fnp-5337	42	12	li	li	NOUN
fnp-5337	42	13	(	(	PUNCT
fnp-5337	42	14	>	>	X
fnp-5337	42	15	40	40	NUM
fnp-5337	42	16	 	 	SPACE
fnp-5337	42	17	%	%	NOUN
fnp-5337	42	18	)	)	PUNCT
fnp-5337	42	19	and	and	CCONJ
fnp-5337	42	20	low	low	ADJ
fnp-5337	42	21	p53	p53	NOUN
fnp-5337	42	22	(	(	PUNCT
fnp-5337	42	23	<	<	X
fnp-5337	42	24	1	1	NUM
fnp-5337	42	25	 	 	SPACE
fnp-5337	42	26	%	%	NOUN
fnp-5337	42	27	)	)	PUNCT
fnp-5337	43	1	li	li	PROPN
fnp-5337	43	2	(	(	PUNCT
fnp-5337	43	3	b	b	NOUN
fnp-5337	43	4	)	)	PUNCT
fnp-5337	43	5	.	.	PUNCT
fnp-5337	44	1	roc	roc	NOUN
fnp-5337	44	2	analysis	analysis	NOUN
fnp-5337	44	3	demonstrated	demonstrate	VERB
fnp-5337	44	4	40	40	NUM
fnp-5337	44	5	 	 	SPACE
fnp-5337	44	6	%	%	NOUN
fnp-5337	44	7	as	as	ADP
fnp-5337	44	8	an	an	DET
fnp-5337	44	9	optimal	optimal	ADJ
fnp-5337	44	10	cutoff	cutoff	NOUN
fnp-5337	44	11	point	point	NOUN
fnp-5337	44	12	for	for	ADP
fnp-5337	44	13	tp53	tp53	PROPN
fnp-5337	44	14	mutation	mutation	NOUN
fnp-5337	44	15	based	base	VERB
fnp-5337	44	16	on	on	ADP
fnp-5337	44	17	ucsf500	ucsf500	PROPN
fnp-5337	44	18	ngs	ng	NOUN
fnp-5337	44	19	confirmation	confirmation	NOUN
fnp-5337	44	20	(	(	PUNCT
fnp-5337	44	21	c	c	NOUN
fnp-5337	44	22	and	and	CCONJ
fnp-5337	44	23	d	d	NOUN
fnp-5337	44	24	)	)	PUNCT
fnp-5337	44	25	.	.	PUNCT
fnp-5337	45	1	(	(	PUNCT
fnp-5337	45	2	loh	loh	NOUN
fnp-5337	45	3	:	:	PUNCT
fnp-5337	45	4	loss	loss	NOUN
fnp-5337	45	5	of	of	ADP
fnp-5337	45	6	heterozygosity	heterozygosity	NOUN
fnp-5337	45	7	,	,	PUNCT
fnp-5337	45	8	cutpoint	cutpoint	NOUN
fnp-5337	45	9	:	:	PUNCT
fnp-5337	45	10	mean	mean	ADJ
fnp-5337	45	11	value	value	NOUN
fnp-5337	45	12	of	of	ADP
fnp-5337	45	13	the	the	DET
fnp-5337	45	14	optimal	optimal	ADJ
fnp-5337	45	15	cutoff	cutoff	NOUN
fnp-5337	45	16	,	,	PUNCT
fnp-5337	45	17	density	density	NOUN
fnp-5337	45	18	:	:	PUNCT
fnp-5337	45	19	distribution	distribution	NOUN
fnp-5337	45	20	of	of	ADP
fnp-5337	45	21	cutoff	cutoff	NOUN
fnp-5337	45	22	values	value	NOUN
fnp-5337	45	23	)	)	PUNCT
fnp-5337	45	24	.	.	PUNCT
fnp-5337	46	1	when	when	SCONJ
fnp-5337	46	2	the	the	DET
fnp-5337	46	3	cut	cut	VERB
fnp-5337	46	4	-	-	PUNCT
fnp-5337	46	5	off	off	ADP
fnp-5337	46	6	values	value	NOUN
fnp-5337	46	7	for	for	ADP
fnp-5337	46	8	p53	p53	NOUN
fnp-5337	46	9	immunohistochemistry	immunohistochemistry	NOUN
fnp-5337	46	10	were	be	AUX
fnp-5337	46	11	considered	consider	VERB
fnp-5337	46	12	,	,	PUNCT
fnp-5337	46	13	the	the	DET
fnp-5337	46	14	positive	positive	ADJ
fnp-5337	46	15	predictive	predictive	ADJ
fnp-5337	46	16	value	value	NOUN
fnp-5337	46	17	of	of	ADP
fnp-5337	46	18	10	10	NUM
fnp-5337	46	19	 	 	SPACE
fnp-5337	46	20	%	%	NOUN
fnp-5337	46	21	labeling	labeling	NOUN
fnp-5337	46	22	index	index	NOUN
fnp-5337	46	23	was	be	AUX
fnp-5337	46	24	calculated	calculate	VERB
fnp-5337	46	25	as	as	ADP
fnp-5337	46	26	60.4	60.4	NUM
fnp-5337	46	27	 	 	SPACE
fnp-5337	46	28	%	%	NOUN
fnp-5337	46	29	,	,	PUNCT
fnp-5337	46	30	while	while	SCONJ
fnp-5337	46	31	the	the	DET
fnp-5337	46	32	negative	negative	ADJ
fnp-5337	46	33	predictive	predictive	ADJ
fnp-5337	46	34	value	value	NOUN
fnp-5337	46	35	at	at	ADP
fnp-5337	46	36	the	the	DET
fnp-5337	46	37	same	same	ADJ
fnp-5337	46	38	cut	cut	NOUN
fnp-5337	46	39	-	-	PUNCT
fnp-5337	46	40	off	off	ADP
fnp-5337	46	41	point	point	NOUN
fnp-5337	46	42	was	be	AUX
fnp-5337	46	43	70.6	70.6	NUM
fnp-5337	46	44	 	 	SPACE
fnp-5337	46	45	%	%	NOUN
fnp-5337	46	46	.	.	PUNCT
fnp-5337	47	1	an	an	DET
fnp-5337	47	2	roc	roc	PROPN
fnp-5337	47	3	analysis	analysis	NOUN
fnp-5337	47	4	based	base	VERB
fnp-5337	47	5	on	on	ADP
fnp-5337	47	6	the	the	DET
fnp-5337	47	7	99	99	NUM
fnp-5337	47	8	patients	patient	NOUN
fnp-5337	47	9	demonstrated	demonstrate	VERB
fnp-5337	47	10	that	that	SCONJ
fnp-5337	47	11	strong	strong	ADJ
fnp-5337	47	12	p53	p53	NOUN
fnp-5337	47	13	staining	stain	VERB
fnp-5337	47	14	in	in	ADP
fnp-5337	47	15	more	more	ADJ
fnp-5337	47	16	than	than	ADP
fnp-5337	47	17	40	40	NUM
fnp-5337	47	18	 	 	SPACE
fnp-5337	47	19	%	%	NOUN
fnp-5337	47	20	of	of	ADP
fnp-5337	47	21	tumor	tumor	NOUN
fnp-5337	47	22	cells	cell	NOUN
fnp-5337	47	23	provided	provide	VERB
fnp-5337	47	24	the	the	DET
fnp-5337	47	25	most	most	ADV
fnp-5337	47	26	accurate	accurate	ADJ
fnp-5337	47	27	prediction	prediction	NOUN
fnp-5337	47	28	of	of	ADP
fnp-5337	47	29	mutation	mutation	NOUN
fnp-5337	47	30	based	base	VERB
fnp-5337	47	31	on	on	ADP
fnp-5337	47	32	youden	youden	PROPN
fnp-5337	47	33	index	index	NOUN
fnp-5337	47	34	(	(	PUNCT
fnp-5337	47	35	figure	figure	NOUN
fnp-5337	47	36	2	2	NUM
fnp-5337	47	37	)	)	PUNCT
fnp-5337	47	38	.	.	PUNCT
fnp-5337	48	1	using	use	VERB
fnp-5337	48	2	this	this	DET
fnp-5337	48	3	cutoff	cutoff	NOUN
fnp-5337	48	4	value	value	NOUN
fnp-5337	48	5	,	,	PUNCT
fnp-5337	48	6	positive	positive	ADJ
fnp-5337	48	7	predictive	predictive	ADJ
fnp-5337	48	8	value	value	NOUN
fnp-5337	48	9	(	(	PUNCT
fnp-5337	48	10	ppv	ppv	NOUN
fnp-5337	48	11	)	)	PUNCT
fnp-5337	48	12	,	,	PUNCT
fnp-5337	48	13	negative	negative	ADJ
fnp-5337	48	14	predictive	predictive	ADJ
fnp-5337	48	15	value	value	NOUN
fnp-5337	48	16	(	(	PUNCT
fnp-5337	48	17	npv	npv	NOUN
fnp-5337	48	18	)	)	PUNCT
fnp-5337	48	19	,	,	PUNCT
fnp-5337	48	20	sensitivity	sensitivity	NOUN
fnp-5337	48	21	,	,	PUNCT
fnp-5337	48	22	and	and	CCONJ
fnp-5337	48	23	specificity	specificity	NOUN
fnp-5337	48	24	were	be	AUX
fnp-5337	48	25	100	100	NUM
fnp-5337	48	26	 	 	SPACE
fnp-5337	48	27	%	%	NOUN
fnp-5337	48	28	,	,	PUNCT
fnp-5337	48	29	73.6	73.6	NUM
fnp-5337	48	30	 	 	SPACE
fnp-5337	48	31	%	%	NOUN
fnp-5337	48	32	,	,	PUNCT
fnp-5337	48	33	67	67	NUM
fnp-5337	48	34	 	 	SPACE
fnp-5337	48	35	%	%	NOUN
fnp-5337	48	36	,	,	PUNCT
fnp-5337	48	37	and	and	CCONJ
fnp-5337	48	38	100	100	NUM
fnp-5337	48	39	 	 	SPACE
fnp-5337	48	40	%	%	NOUN
fnp-5337	48	41	,	,	PUNCT
fnp-5337	48	42	respectively	respectively	ADV
fnp-5337	48	43	.	.	PUNCT
fnp-5337	49	1	most	most	ADJ
fnp-5337	49	2	of	of	ADP
fnp-5337	49	3	the	the	DET
fnp-5337	49	4	inaccuracy	inaccuracy	NOUN
fnp-5337	49	5	could	could	AUX
fnp-5337	49	6	be	be	AUX
fnp-5337	49	7	attributed	attribute	VERB
fnp-5337	49	8	to	to	ADP
fnp-5337	49	9	tumors	tumor	NOUN
fnp-5337	49	10	with	with	ADP
fnp-5337	49	11	frameshift	frameshift	ADJ
fnp-5337	49	12	mutations	mutation	NOUN
fnp-5337	49	13	,	,	PUNCT
fnp-5337	49	14	which	which	PRON
fnp-5337	49	15	frequently	frequently	ADV
fnp-5337	49	16	demonstrated	demonstrate	VERB
fnp-5337	49	17	the	the	DET
fnp-5337	49	18	null	null	ADJ
fnp-5337	49	19	cell	cell	NOUN
fnp-5337	49	20	pattern	pattern	NOUN
fnp-5337	49	21	with	with	ADP
fnp-5337	49	22	absent	absent	ADJ
fnp-5337	49	23	immunostaining	immunostaining	NOUN
fnp-5337	49	24	(	(	PUNCT
fnp-5337	49	25	with	with	ADP
fnp-5337	49	26	p53	p53	PROPN
fnp-5337	49	27	li	li	PROPN
fnp-5337	49	28	of	of	ADP
fnp-5337	49	29	<	<	PROPN
fnp-5337	49	30	1	1	NUM
fnp-5337	49	31	 	 	SPACE
fnp-5337	49	32	%	%	NOUN
fnp-5337	49	33	)	)	PUNCT
fnp-5337	49	34	.	.	PUNCT
fnp-5337	50	1	after	after	ADP
fnp-5337	50	2	excluding	exclude	VERB
fnp-5337	50	3	the	the	DET
fnp-5337	50	4	tumor	tumor	NOUN
fnp-5337	50	5	with	with	ADP
fnp-5337	50	6	frameshift	frameshift	ADJ
fnp-5337	50	7	mutations	mutation	NOUN
fnp-5337	50	8	,	,	PUNCT
fnp-5337	50	9	an	an	DET
fnp-5337	50	10	roc	roc	PROPN
fnp-5337	50	11	analysis	analysis	NOUN
fnp-5337	50	12	redemonstrated	redemonstrate	VERB
fnp-5337	50	13	that	that	SCONJ
fnp-5337	50	14	the	the	DET
fnp-5337	50	15	best	good	ADJ
fnp-5337	50	16	cutoff	cutoff	NOUN
fnp-5337	50	17	for	for	ADP
fnp-5337	50	18	p53	p53	NOUN
fnp-5337	50	19	li	li	PROPN
fnp-5337	50	20	as	as	ADP
fnp-5337	50	21	still	still	ADV
fnp-5337	50	22	40	40	NUM
fnp-5337	50	23	 	 	SPACE
fnp-5337	50	24	%	%	NOUN
fnp-5337	50	25	with	with	ADP
fnp-5337	50	26	ppv	ppv	NOUN
fnp-5337	50	27	,	,	PUNCT
fnp-5337	50	28	npv	npv	NOUN
fnp-5337	50	29	,	,	PUNCT
fnp-5337	50	30	sensitivity	sensitivity	NOUN
fnp-5337	50	31	,	,	PUNCT
fnp-5337	50	32	and	and	CCONJ
fnp-5337	50	33	specificity	specificity	NOUN
fnp-5337	50	34	calculated	calculate	VERB
fnp-5337	50	35	as	as	ADP
fnp-5337	50	36	100	100	NUM
fnp-5337	50	37	 	 	SPACE
fnp-5337	50	38	%	%	NOUN
fnp-5337	50	39	,	,	PUNCT
fnp-5337	50	40	81	81	NUM
fnp-5337	50	41	 	 	SPACE
fnp-5337	50	42	%	%	NOUN
fnp-5337	50	43	,	,	PUNCT
fnp-5337	50	44	88	88	NUM
fnp-5337	50	45	 	 	SPACE
fnp-5337	50	46	%	%	NOUN
fnp-5337	50	47	,	,	PUNCT
fnp-5337	50	48	and	and	CCONJ
fnp-5337	50	49	100	100	NUM
fnp-5337	50	50	 	 	SPACE
fnp-5337	50	51	%	%	NOUN
fnp-5337	50	52	,	,	PUNCT
fnp-5337	50	53	respectively	respectively	ADV
fnp-5337	50	54	.	.	PUNCT
fnp-5337	51	1	these	these	DET
fnp-5337	51	2	findings	finding	NOUN
fnp-5337	51	3	suggest	suggest	VERB
fnp-5337	51	4	,	,	PUNCT
fnp-5337	51	5	as	as	SCONJ
fnp-5337	51	6	previously	previously	ADV
fnp-5337	51	7	demonstrated	demonstrate	VERB
fnp-5337	51	8	by	by	ADP
fnp-5337	51	9	many	many	ADJ
fnp-5337	51	10	,	,	PUNCT
fnp-5337	51	11	that	that	DET
fnp-5337	51	12	p53	p53	NOUN
fnp-5337	51	13	immunostaining	immunostaining	NOUN
fnp-5337	51	14	can	can	AUX
fnp-5337	51	15	not	not	PART
fnp-5337	51	16	be	be	AUX
fnp-5337	51	17	taken	take	VERB
fnp-5337	51	18	as	as	ADP
fnp-5337	51	19	prima	prima	NOUN
fnp-5337	51	20	facia	facia	NOUN
fnp-5337	51	21	evidence	evidence	NOUN
fnp-5337	51	22	of	of	ADP
fnp-5337	51	23	tp53	tp53	PROPN
fnp-5337	51	24	mutations	mutation	NOUN
fnp-5337	51	25	.	.	PUNCT
fnp-5337	52	1	furthermore	furthermore	ADV
fnp-5337	52	2	,	,	PUNCT
fnp-5337	52	3	our	our	PRON
fnp-5337	52	4	data	datum	NOUN
fnp-5337	52	5	suggest	suggest	VERB
fnp-5337	52	6	that	that	SCONJ
fnp-5337	52	7	the	the	DET
fnp-5337	52	8	cut	cut	VERB
fnp-5337	52	9	-	-	PUNCT
fnp-5337	52	10	off	off	ADP
fnp-5337	52	11	value	value	NOUN
fnp-5337	52	12	recommended	recommend	VERB
fnp-5337	52	13	by	by	ADP
fnp-5337	52	14	the	the	DET
fnp-5337	52	15	cns	cns	NOUN
fnp-5337	52	16	who	who	PRON
fnp-5337	52	17	classification	classification	VERB
fnp-5337	52	18	to	to	PART
fnp-5337	52	19	predict	predict	VERB
fnp-5337	52	20	tp53	tp53	PROPN
fnp-5337	52	21	mutations	mutation	NOUN
fnp-5337	52	22	may	may	AUX
fnp-5337	52	23	be	be	AUX
fnp-5337	52	24	inaccurate	inaccurate	ADJ
fnp-5337	52	25	and	and	CCONJ
fnp-5337	52	26	should	should	AUX
fnp-5337	52	27	be	be	AUX
fnp-5337	52	28	reevaluated	reevaluate	VERB
fnp-5337	52	29	.	.	PUNCT
fnp-5337	53	1	this	this	DET
fnp-5337	53	2	issue	issue	NOUN
fnp-5337	53	3	underscores	underscore	VERB
fnp-5337	53	4	the	the	DET
fnp-5337	53	5	problem	problem	NOUN
fnp-5337	53	6	of	of	ADP
fnp-5337	53	7	accepting	accept	VERB
fnp-5337	53	8	results	result	NOUN
fnp-5337	53	9	of	of	ADP
fnp-5337	53	10	single	single	ADJ
fnp-5337	53	11	studies	study	NOUN
fnp-5337	53	12	without	without	ADP
fnp-5337	53	13	appropriate	appropriate	ADJ
fnp-5337	53	14	validation	validation	NOUN
fnp-5337	53	15	and	and	CCONJ
fnp-5337	53	16	confirmation	confirmation	NOUN
fnp-5337	53	17	by	by	ADP
fnp-5337	53	18	more	more	ADJ
fnp-5337	53	19	than	than	ADP
fnp-5337	53	20	one	one	NUM
fnp-5337	53	21	independent	independent	ADJ
fnp-5337	53	22	scientific	scientific	ADJ
fnp-5337	53	23	observation	observation	NOUN
fnp-5337	53	24	for	for	ADP
fnp-5337	53	25	the	the	DET
fnp-5337	53	26	purposes	purpose	NOUN
fnp-5337	53	27	of	of	ADP
fnp-5337	53	28	standardized	standardized	ADJ
fnp-5337	53	29	classification	classification	NOUN
fnp-5337	53	30	systems	system	NOUN
fnp-5337	53	31	that	that	PRON
fnp-5337	53	32	would	would	AUX
fnp-5337	53	33	be	be	AUX
fnp-5337	53	34	used	use	VERB
fnp-5337	53	35	worldwide	worldwide	ADV
fnp-5337	53	36	.	.	PUNCT
fnp-5337	54	1	we	we	PRON
fnp-5337	54	2	believe	believe	VERB
fnp-5337	54	3	that	that	SCONJ
fnp-5337	54	4	previously	previously	ADV
fnp-5337	54	5	suggested	suggest	VERB
fnp-5337	54	6	p53	p53	NOUN
fnp-5337	54	7	labeling	labeling	NOUN
fnp-5337	54	8	index	index	NOUN
fnp-5337	54	9	of	of	ADP
fnp-5337	54	10	10	10	NUM
fnp-5337	54	11	 	 	SPACE
fnp-5337	54	12	%	%	NOUN
fnp-5337	54	13	as	as	ADP
fnp-5337	54	14	predictive	predictive	NOUN
fnp-5337	54	15	of	of	ADP
fnp-5337	54	16	tp53	tp53	PROPN
fnp-5337	54	17	mutation	mutation	NOUN
fnp-5337	54	18	significantly	significantly	ADV
fnp-5337	54	19	overestimates	overestimate	VERB
fnp-5337	54	20	mutations	mutation	NOUN
fnp-5337	54	21	,	,	PUNCT
fnp-5337	54	22	which	which	PRON
fnp-5337	54	23	could	could	AUX
fnp-5337	54	24	potentially	potentially	ADV
fnp-5337	54	25	lead	lead	VERB
fnp-5337	54	26	to	to	ADP
fnp-5337	54	27	erroneous	erroneous	ADJ
fnp-5337	54	28	conclusions	conclusion	NOUN
fnp-5337	54	29	in	in	ADP
fnp-5337	54	30	the	the	DET
fnp-5337	54	31	absence	absence	NOUN
fnp-5337	54	32	of	of	ADP
fnp-5337	54	33	molecular	molecular	ADJ
fnp-5337	54	34	confirmation	confirmation	NOUN
fnp-5337	54	35	.	.	PUNCT
fnp-5337	55	1	considering	consider	VERB
fnp-5337	55	2	possible	possible	ADJ
fnp-5337	55	3	variations	variation	NOUN
fnp-5337	55	4	when	when	SCONJ
fnp-5337	55	5	performed	perform	VERB
fnp-5337	55	6	in	in	ADP
fnp-5337	55	7	different	different	ADJ
fnp-5337	55	8	laboratories	laboratory	NOUN
fnp-5337	55	9	and	and	CCONJ
fnp-5337	55	10	using	use	VERB
fnp-5337	55	11	different	different	ADJ
fnp-5337	55	12	antibodies	antibody	NOUN
fnp-5337	55	13	,	,	PUNCT
fnp-5337	55	14	this	this	DET
fnp-5337	55	15	cut	cut	VERB
fnp-5337	55	16	-	-	PUNCT
fnp-5337	55	17	off	off	ADP
fnp-5337	55	18	value	value	NOUN
fnp-5337	55	19	becomes	become	VERB
fnp-5337	55	20	even	even	ADV
fnp-5337	55	21	less	less	ADV
fnp-5337	55	22	predictive	predictive	ADJ
fnp-5337	55	23	.	.	PUNCT
fnp-5337	56	1	for	for	ADP
fnp-5337	56	2	practical	practical	ADJ
fnp-5337	56	3	purposes	purpose	NOUN
fnp-5337	56	4	,	,	PUNCT
fnp-5337	56	5	we	we	PRON
fnp-5337	56	6	recommend	recommend	VERB
fnp-5337	56	7	the	the	DET
fnp-5337	56	8	use	use	NOUN
fnp-5337	56	9	of	of	ADP
fnp-5337	56	10	>	>	SYM
fnp-5337	56	11	40	40	NUM
fnp-5337	56	12	 	 	SPACE
fnp-5337	56	13	%	%	NOUN
fnp-5337	56	14	as	as	ADP
fnp-5337	56	15	a	a	DET
fnp-5337	56	16	more	more	ADV
fnp-5337	56	17	robust	robust	ADJ
fnp-5337	56	18	and	and	CCONJ
fnp-5337	56	19	predictive	predictive	ADJ
fnp-5337	56	20	cut	cut	NOUN
fnp-5337	56	21	-	-	PUNCT
fnp-5337	56	22	off	off	ADP
fnp-5337	56	23	value	value	NOUN
fnp-5337	56	24	for	for	ADP
fnp-5337	56	25	p53	p53	NOUN
fnp-5337	56	26	immunohistochemistry	immunohistochemistry	NOUN
fnp-5337	56	27	,	,	PUNCT
fnp-5337	56	28	while	while	SCONJ
fnp-5337	56	29	still	still	ADV
fnp-5337	56	30	acknowledging	acknowledge	VERB
fnp-5337	56	31	that	that	SCONJ
fnp-5337	56	32	there	there	PRON
fnp-5337	56	33	will	will	AUX
fnp-5337	56	34	always	always	ADV
fnp-5337	56	35	be	be	AUX
fnp-5337	56	36	outliers	outlier	NOUN
fnp-5337	56	37	regardless	regardless	ADV
fnp-5337	56	38	of	of	ADP
fnp-5337	56	39	the	the	DET
fnp-5337	56	40	cut	cut	VERB
fnp-5337	56	41	-	-	PUNCT
fnp-5337	56	42	off	off	ADP
fnp-5337	56	43	number	number	NOUN
fnp-5337	56	44	utilized	utilize	VERB
fnp-5337	56	45	.	.	PUNCT
fnp-5337	57	1	finally	finally	ADV
fnp-5337	57	2	,	,	PUNCT
fnp-5337	57	3	the	the	DET
fnp-5337	57	4	absence	absence	NOUN
fnp-5337	57	5	of	of	ADP
fnp-5337	57	6	staining	stain	VERB
fnp-5337	57	7	does	do	AUX
fnp-5337	57	8	not	not	PART
fnp-5337	57	9	rule	rule	VERB
fnp-5337	57	10	out	out	ADP
fnp-5337	57	11	a	a	DET
fnp-5337	57	12	tp53	tp53	PROPN
fnp-5337	57	13	mutation	mutation	NOUN
fnp-5337	57	14	,	,	PUNCT
fnp-5337	57	15	and	and	CCONJ
fnp-5337	57	16	thus	thus	ADV
fnp-5337	57	17	should	should	AUX
fnp-5337	57	18	be	be	AUX
fnp-5337	57	19	interpreted	interpret	VERB
fnp-5337	57	20	with	with	ADP
fnp-5337	57	21	caution	caution	NOUN
fnp-5337	57	22	.	.	PUNCT
fnp-5337	58	1	references	reference	NOUN
fnp-5337	58	2	1	1	NUM
fnp-5337	58	3	.	.	X
fnp-5337	58	4	appin	appin	NOUN
fnp-5337	58	5	cl	cl	NOUN
fnp-5337	58	6	,	,	PUNCT
fnp-5337	58	7	brat	brat	NOUN
fnp-5337	58	8	dj	dj	PROPN
fnp-5337	58	9	.	.	PROPN
fnp-5337	58	10	biomarker	biomarker	NOUN
fnp-5337	58	11	-	-	PUNCT
fnp-5337	58	12	driven	drive	VERB
fnp-5337	58	13	diagnosis	diagnosis	NOUN
fnp-5337	58	14	of	of	ADP
fnp-5337	58	15	diffuse	diffuse	NOUN
fnp-5337	58	16	gliomas	glioma	NOUN
fnp-5337	58	17	.	.	PUNCT
fnp-5337	59	1	mol	mol	ADP
fnp-5337	59	2	aspects	aspect	NOUN
fnp-5337	59	3	med	me	VERB
fnp-5337	59	4	[	[	X
fnp-5337	59	5	internet	internet	NOUN
fnp-5337	59	6	]	]	PUNCT
fnp-5337	59	7	2015	2015	NUM
fnp-5337	59	8	[	[	X
fnp-5337	59	9	cited	cite	VERB
fnp-5337	59	10	2023	2023	NUM
fnp-5337	59	11	mar	mar	PROPN
fnp-5337	59	12	4];45:87–96	4];45:87–96	NUM
fnp-5337	59	13	.	.	PUNCT
fnp-5337	60	1	https://doi.org/10.1016/j.mam.2015.05.002	https://doi.org/10.1016/j.mam.2015.05.002	NOUN
fnp-5337	60	2	2	2	NUM
fnp-5337	60	3	.	.	PUNCT
fnp-5337	60	4	dj	dj	PROPN
fnp-5337	60	5	b	b	PROPN
fnp-5337	60	6	,	,	PUNCT
fnp-5337	60	7	rg	rg	PROPN
fnp-5337	60	8	v	v	NOUN
fnp-5337	60	9	,	,	PUNCT
fnp-5337	60	10	kd	kd	PROPN
fnp-5337	60	11	a	a	PRON
fnp-5337	60	12	,	,	PUNCT
fnp-5337	60	13	et	et	PROPN
fnp-5337	60	14	al	al	PROPN
fnp-5337	60	15	.	.	PROPN
fnp-5337	60	16	comprehensive	comprehensive	ADJ
fnp-5337	60	17	,	,	PUNCT
fnp-5337	60	18	integrative	integrative	ADJ
fnp-5337	60	19	genomic	genomic	ADJ
fnp-5337	60	20	analysis	analysis	NOUN
fnp-5337	60	21	of	of	ADP
fnp-5337	60	22	diffuse	diffuse	ADJ
fnp-5337	60	23	lower	low	ADJ
fnp-5337	60	24	-	-	PUNCT
fnp-5337	60	25	grade	grade	NOUN
fnp-5337	60	26	gliomas	glioma	NOUN
fnp-5337	60	27	.	.	PUNCT
fnp-5337	61	1	n	n	PRON
fnp-5337	61	2	engl	engl	PROPN
fnp-5337	61	3	j	j	PROPN
fnp-5337	61	4	med	med	PROPN
fnp-5337	62	1	[	[	X
fnp-5337	62	2	internet	internet	NOUN
fnp-5337	62	3	]	]	PUNCT
fnp-5337	62	4	2015	2015	NUM
fnp-5337	62	5	[	[	X
fnp-5337	62	6	cited	cite	VERB
fnp-5337	62	7	2023	2023	NUM
fnp-5337	62	8	mar	mar	PROPN
fnp-5337	62	9	4];372(26):2481–98	4];372(26):2481–98	NUM
fnp-5337	62	10	.	.	PUNCT
fnp-5337	63	1	https://doi.org/10.1056/nejmoa1402121	https://doi.org/10.1056/nejmoa1402121	VERB
fnp-5337	63	2	3	3	NUM
fnp-5337	63	3	.	.	PUNCT
fnp-5337	63	4	eckel	eckel	NOUN
fnp-5337	63	5	-	-	PUNCT
fnp-5337	63	6	passow	passow	NOUN
fnp-5337	63	7	je	je	PROPN
fnp-5337	63	8	,	,	PUNCT
fnp-5337	63	9	lachance	lachance	PROPN
fnp-5337	63	10	dh	dh	PROPN
fnp-5337	63	11	,	,	PUNCT
fnp-5337	63	12	molinaro	molinaro	PROPN
fnp-5337	63	13	am	be	AUX
fnp-5337	63	14	,	,	PUNCT
fnp-5337	63	15	et	et	PROPN
fnp-5337	63	16	al	al	PROPN
fnp-5337	63	17	.	.	PROPN
fnp-5337	64	1	glioma	glioma	NOUN
fnp-5337	64	2	groups	group	NOUN
fnp-5337	64	3	based	base	VERB
fnp-5337	64	4	on	on	ADP
fnp-5337	64	5	1p/19q	1p/19q	PROPN
fnp-5337	64	6	,	,	PUNCT
fnp-5337	64	7	idh	idh	PROPN
fnp-5337	64	8	,	,	PUNCT
fnp-5337	64	9	and	and	CCONJ
fnp-5337	64	10	tert	tert	NOUN
fnp-5337	64	11	promoter	promoter	NOUN
fnp-5337	64	12	mutations	mutation	NOUN
fnp-5337	64	13	in	in	ADP
fnp-5337	64	14	tumors	tumor	NOUN
fnp-5337	64	15	.	.	PUNCT
fnp-5337	65	1	new	new	PROPN
fnp-5337	65	2	england	england	PROPN
fnp-5337	65	3	journal	journal	PROPN
fnp-5337	65	4	of	of	ADP
fnp-5337	65	5	medicine	medicine	NOUN
fnp-5337	65	6	[	[	X
fnp-5337	65	7	internet	internet	NOUN
fnp-5337	65	8	]	]	PUNCT
fnp-5337	65	9	2015	2015	NUM
fnp-5337	66	1	[	[	X
fnp-5337	66	2	cited	cite	VERB
fnp-5337	66	3	2023	2023	NUM
fnp-5337	66	4	mar	mar	PROPN
fnp-5337	66	5	4];372(26):2499–508	4];372(26):2499–508	PROPN
fnp-5337	66	6	.	.	PUNCT
fnp-5337	67	1	https://doi.org/10.1056/nejmoa1407279	https://doi.org/10.1056/nejmoa1407279	PROPN
fnp-5337	67	2	4	4	NUM
fnp-5337	67	3	.	.	PUNCT
fnp-5337	68	1	brat	brat	PROPN
fnp-5337	68	2	dj	dj	PROPN
fnp-5337	68	3	,	,	PUNCT
fnp-5337	68	4	reuss	reuss	PROPN
fnp-5337	68	5	de	de	PROPN
fnp-5337	68	6	,	,	PUNCT
fnp-5337	68	7	von	von	PROPN
fnp-5337	68	8	deimling	deimle	VERB
fnp-5337	68	9	a	a	PRON
fnp-5337	68	10	,	,	PUNCT
fnp-5337	68	11	et	et	PROPN
fnp-5337	68	12	al	al	PROPN
fnp-5337	68	13	.	.	PUNCT
fnp-5337	69	1	who	who	PRON
fnp-5337	69	2	classification	classification	NOUN
fnp-5337	69	3	of	of	ADP
fnp-5337	69	4	tumours	tumours	PROPN
fnp-5337	69	5	editorial	editorial	PROPN
fnp-5337	69	6	board	board	PROPN
fnp-5337	69	7	.	.	PUNCT
fnp-5337	70	1	central	central	ADJ
fnp-5337	70	2	nervous	nervous	ADJ
fnp-5337	70	3	system	system	NOUN
fnp-5337	70	4	tumours	tumour	VERB
fnp-5337	70	5	.	.	PUNCT
fnp-5337	71	1	5th	5th	ADJ
fnp-5337	71	2	ed	ed	NOUN
fnp-5337	71	3	.	.	PROPN
fnp-5337	71	4	2021	2021	NUM
fnp-5337	71	5	.	.	PUNCT
fnp-5337	72	1	5	5	X
fnp-5337	72	2	.	.	X
fnp-5337	72	3	takano	takano	PROPN
fnp-5337	72	4	s	s	PROPN
fnp-5337	72	5	,	,	PUNCT
fnp-5337	72	6	ishikawa	ishikawa	PROPN
fnp-5337	72	7	e	e	PROPN
fnp-5337	72	8	,	,	PUNCT
fnp-5337	72	9	sakamoto	sakamoto	PROPN
fnp-5337	72	10	n	n	CCONJ
fnp-5337	72	11	,	,	PUNCT
fnp-5337	72	12	et	et	PROPN
fnp-5337	72	13	al	al	PROPN
fnp-5337	72	14	.	.	PROPN
fnp-5337	72	15	immunohistochemistry	immunohistochemistry	PROPN
fnp-5337	72	16	on	on	ADP
fnp-5337	72	17	idh	idh	PROPN
fnp-5337	72	18	1/2	1/2	NUM
fnp-5337	72	19	,	,	PUNCT
fnp-5337	72	20	atrx	atrx	VERB
fnp-5337	72	21	,	,	PUNCT
fnp-5337	72	22	p53	p53	NOUN
fnp-5337	72	23	and	and	CCONJ
fnp-5337	72	24	ki-67	ki-67	ADJ
fnp-5337	72	25	substitute	substitute	NOUN
fnp-5337	72	26	molecular	molecular	ADJ
fnp-5337	72	27	genetic	genetic	ADJ
fnp-5337	72	28	testing	testing	NOUN
fnp-5337	72	29	and	and	CCONJ
fnp-5337	72	30	predict	predict	VERB
fnp-5337	72	31	patient	patient	ADJ
fnp-5337	72	32	prognosis	prognosis	NOUN
fnp-5337	72	33	in	in	ADP
fnp-5337	72	34	grade	grade	NOUN
fnp-5337	72	35	iii	iii	NUM
fnp-5337	72	36	adult	adult	NOUN
fnp-5337	72	37	diffuse	diffuse	NOUN
fnp-5337	72	38	gliomas	glioma	NOUN
fnp-5337	72	39	.	.	PUNCT
fnp-5337	73	1	brain	brain	NOUN
fnp-5337	73	2	tumor	tumor	NOUN
fnp-5337	73	3	pathol	pathol	NOUN
fnp-5337	73	4	[	[	X
fnp-5337	73	5	internet	internet	NOUN
fnp-5337	73	6	]	]	PUNCT
fnp-5337	73	7	2016	2016	NUM
fnp-5337	74	1	[	[	X
fnp-5337	74	2	cited	cite	VERB
fnp-5337	74	3	2023	2023	NUM
fnp-5337	74	4	mar	mar	PROPN
fnp-5337	74	5	4];33(2):107–16	4];33(2):107–16	PUNCT
fnp-5337	74	6	.	.	PUNCT
fnp-5337	75	1	https://doi.org/10.1007/s10014-016-0260-x	https://doi.org/10.1007/s10014-016-0260-x	NOUN
fnp-5337	75	2	6	6	NUM
fnp-5337	75	3	.	.	PUNCT
fnp-5337	76	1	ogura	ogura	PROPN
fnp-5337	76	2	r	r	PROPN
fnp-5337	76	3	,	,	PUNCT
fnp-5337	76	4	tsukamoto	tsukamoto	PROPN
fnp-5337	76	5	y	y	PROPN
fnp-5337	76	6	,	,	PUNCT
fnp-5337	76	7	natsumeda	natsumeda	PROPN
fnp-5337	76	8	m	m	PROPN
fnp-5337	76	9	,	,	PUNCT
fnp-5337	76	10	et	et	PROPN
fnp-5337	76	11	al	al	PROPN
fnp-5337	76	12	.	.	PUNCT
fnp-5337	76	13	immunohistochemical	immunohistochemical	ADJ
fnp-5337	76	14	profiles	profile	NOUN
fnp-5337	76	15	of	of	ADP
fnp-5337	76	16	idh1	idh1	PROPN
fnp-5337	76	17	,	,	PUNCT
fnp-5337	76	18	mgmt	mgmt	NOUN
fnp-5337	76	19	and	and	CCONJ
fnp-5337	76	20	p53	p53	NOUN
fnp-5337	76	21	:	:	PUNCT
fnp-5337	76	22	practical	practical	ADJ
fnp-5337	76	23	significance	significance	NOUN
fnp-5337	76	24	for	for	ADP
fnp-5337	76	25	prognostication	prognostication	NOUN
fnp-5337	76	26	of	of	ADP
fnp-5337	76	27	patients	patient	NOUN
fnp-5337	76	28	with	with	ADP
fnp-5337	76	29	diffuse	diffuse	ADJ
fnp-5337	76	30	gliomas	glioma	NOUN
fnp-5337	76	31	.	.	PUNCT
fnp-5337	77	1	neuropathology	neuropathology	NOUN
fnp-5337	78	1	[	[	X
fnp-5337	78	2	internet	internet	NOUN
fnp-5337	78	3	]	]	PUNCT
fnp-5337	78	4	2015	2015	NUM
fnp-5337	78	5	[	[	X
fnp-5337	78	6	cited	cite	VERB
fnp-5337	78	7	2023	2023	NUM
fnp-5337	78	8	mar	mar	PROPN
fnp-5337	78	9	4];35(4):324–35	4];35(4):324–35	PROPN
fnp-5337	78	10	.	.	PROPN
fnp-5337	78	11	https://doi.org/10.1111/neup.12196	https://doi.org/10.1111/neup.12196	ADJ
fnp-5337	78	12	7	7	NUM
fnp-5337	78	13	.	.	PUNCT
fnp-5337	79	1	shao	shao	PROPN
fnp-5337	79	2	lw	lw	PROPN
fnp-5337	79	3	,	,	PUNCT
fnp-5337	79	4	pan	pan	PROPN
fnp-5337	79	5	y	y	PROPN
fnp-5337	79	6	,	,	PUNCT
fnp-5337	79	7	qi	qi	PROPN
fnp-5337	79	8	xl	xl	PROPN
fnp-5337	79	9	,	,	PUNCT
fnp-5337	79	10	et	et	PROPN
fnp-5337	79	11	al	al	PROPN
fnp-5337	79	12	.	.	PUNCT
fnp-5337	79	13	atrx	atrx	PROPN
fnp-5337	79	14	loss	loss	NOUN
fnp-5337	79	15	in	in	ADP
fnp-5337	79	16	adult	adult	NOUN
fnp-5337	79	17	supratentorial	supratentorial	ADJ
fnp-5337	79	18	diffuse	diffuse	NOUN
fnp-5337	79	19	astrocytomas	astrocytoma	NOUN
fnp-5337	79	20	correlates	correlate	VERB
fnp-5337	79	21	with	with	ADP
fnp-5337	79	22	p53	p53	NOUN
fnp-5337	79	23	over	over	ADP
fnp-5337	79	24	expression	expression	NOUN
fnp-5337	79	25	and	and	CCONJ
fnp-5337	79	26	idh1	idh1	NOUN
fnp-5337	79	27	mutation	mutation	NOUN
fnp-5337	79	28	and	and	CCONJ
fnp-5337	79	29	predicts	predict	VERB
fnp-5337	79	30	better	well	ADJ
fnp-5337	79	31	outcome	outcome	VERB
fnp-5337	79	32	in	in	ADP
fnp-5337	79	33	p53	p53	NOUN
fnp-5337	79	34	accumulated	accumulate	VERB
fnp-5337	79	35	patients	patient	NOUN
fnp-5337	79	36	.	.	PUNCT
fnp-5337	80	1	histol	histol	VERB
fnp-5337	80	2	histopathol	histopathol	NOUN
fnp-5337	81	1	[	[	X
fnp-5337	81	2	internet	internet	NOUN
fnp-5337	81	3	]	]	PUNCT
fnp-5337	81	4	2016	2016	NUM
fnp-5337	81	5	[	[	X
fnp-5337	81	6	cited	cite	VERB
fnp-5337	81	7	2023	2023	NUM
fnp-5337	81	8	mar	mar	PROPN
fnp-5337	81	9	4];31(1):103–14	4];31(1):103–14	PROPN
fnp-5337	81	10	.	.	PUNCT
fnp-5337	82	1	https://doi.org/10.14670/hh-11-664	https://doi.org/10.14670/hh-11-664	PROPN
fnp-5337	82	2	8	8	X
fnp-5337	82	3	.	.	PUNCT
fnp-5337	82	4	antonelli	antonelli	PROPN
fnp-5337	82	5	m	m	PROPN
fnp-5337	82	6	,	,	PUNCT
fnp-5337	82	7	buttarelli	buttarelli	PROPN
fnp-5337	82	8	fr	fr	PROPN
fnp-5337	82	9	,	,	PUNCT
fnp-5337	82	10	arcella	arcella	PROPN
fnp-5337	82	11	a	a	PROPN
fnp-5337	82	12	,	,	PUNCT
fnp-5337	82	13	et	et	PROPN
fnp-5337	82	14	al	al	PROPN
fnp-5337	82	15	.	.	PROPN
fnp-5337	82	16	prognostic	prognostic	ADJ
fnp-5337	82	17	significance	significance	NOUN
fnp-5337	82	18	of	of	ADP
fnp-5337	82	19	histological	histological	ADJ
fnp-5337	82	20	grading	grading	NOUN
fnp-5337	82	21	,	,	PUNCT
fnp-5337	82	22	p53	p53	NOUN
fnp-5337	82	23	status	status	NOUN
fnp-5337	82	24	,	,	PUNCT
fnp-5337	82	25	ykl-40	ykl-40	NOUN
fnp-5337	82	26	expression	expression	NOUN
fnp-5337	82	27	,	,	PUNCT
fnp-5337	82	28	and	and	CCONJ
fnp-5337	82	29	idh1	idh1	PROPN
fnp-5337	82	30	mutations	mutation	NOUN
fnp-5337	82	31	in	in	ADP
fnp-5337	82	32	pediatric	pediatric	ADJ
fnp-5337	82	33	high	high	ADJ
fnp-5337	82	34	-	-	PUNCT
fnp-5337	82	35	grade	grade	NOUN
fnp-5337	82	36	gliomas	glioma	NOUN
fnp-5337	82	37	.	.	PUNCT
fnp-5337	83	1	j	j	PROPN
fnp-5337	83	2	neurooncol	neurooncol	PROPN
fnp-5337	84	1	[	[	X
fnp-5337	84	2	internet	internet	NOUN
fnp-5337	84	3	]	]	PUNCT
fnp-5337	84	4	2010	2010	NUM
fnp-5337	85	1	[	[	X
fnp-5337	85	2	cited	cite	VERB
fnp-5337	85	3	2023	2023	NUM
fnp-5337	85	4	mar	mar	PROPN
fnp-5337	85	5	4];99(2):209–15	4];99(2):209–15	NUM
fnp-5337	85	6	.	.	PUNCT
fnp-5337	86	1	https://doi.org/10.1007/s11060-010-0129-5	https://doi.org/10.1007/s11060-010-0129-5	NUM
fnp-5337	86	2	9	9	NUM
fnp-5337	86	3	.	.	PUNCT
fnp-5337	86	4	newcomb	newcomb	PROPN
fnp-5337	86	5	ew	ew	PROPN
fnp-5337	86	6	,	,	PUNCT
fnp-5337	86	7	madonia	madonia	PROPN
fnp-5337	86	8	wj	wj	PROPN
fnp-5337	86	9	,	,	PUNCT
fnp-5337	86	10	pisharody	pisharody	NOUN
fnp-5337	86	11	s	s	PROPN
fnp-5337	86	12	,	,	PUNCT
fnp-5337	86	13	lang	lang	PROPN
fnp-5337	86	14	ff	ff	PROPN
fnp-5337	86	15	,	,	PUNCT
fnp-5337	86	16	koslow	koslow	PROPN
fnp-5337	86	17	m	m	PROPN
fnp-5337	86	18	,	,	PUNCT
fnp-5337	86	19	miller	miller	PROPN
fnp-5337	86	20	dc	dc	PROPN
fnp-5337	86	21	.	.	PUNCT
fnp-5337	87	1	a	a	DET
fnp-5337	87	2	correlative	correlative	ADJ
fnp-5337	87	3	study	study	NOUN
fnp-5337	87	4	of	of	ADP
fnp-5337	87	5	p53	p53	NOUN
fnp-5337	87	6	protein	protein	NOUN
fnp-5337	87	7	alteration	alteration	NOUN
fnp-5337	87	8	and	and	CCONJ
fnp-5337	87	9	p53	p53	NOUN
fnp-5337	87	10	gene	gene	NOUN
fnp-5337	87	11	mutation	mutation	NOUN
fnp-5337	87	12	in	in	ADP
fnp-5337	87	13	glioblastoma	glioblastoma	NOUN
fnp-5337	87	14	multiforme	multiforme	NOUN
fnp-5337	87	15	.	.	PUNCT
fnp-5337	88	1	brain	brain	NOUN
fnp-5337	88	2	pathol	pathol	NOUN
fnp-5337	88	3	[	[	X
fnp-5337	88	4	internet	internet	NOUN
fnp-5337	88	5	]	]	PUNCT
fnp-5337	88	6	1993	1993	NUM
fnp-5337	89	1	[	[	X
fnp-5337	89	2	cited	cite	VERB
fnp-5337	89	3	2023	2023	NUM
fnp-5337	89	4	mar	mar	PROPN
fnp-5337	89	5	4];3(3):229–35	4];3(3):229–35	NUM
fnp-5337	89	6	.	.	PUNCT
fnp-5337	90	1	https://doi.org/10.1111/j.1750-3639.1993.tb00749.x	https://doi.org/10.1111/j.1750-3639.1993.tb00749.x	PROPN
fnp-5337	90	2	10	10	NUM
fnp-5337	90	3	.	.	PUNCT
fnp-5337	91	1	faria	faria	PROPN
fnp-5337	91	2	mhg	mhg	PROPN
fnp-5337	91	3	,	,	PUNCT
fnp-5337	91	4	neves	neves	PROPN
fnp-5337	91	5	filho	filho	PROPN
fnp-5337	91	6	ehc	ehc	PROPN
fnp-5337	91	7	,	,	PUNCT
fnp-5337	91	8	alves	alves	PROPN
fnp-5337	91	9	mks	mks	PROPN
fnp-5337	91	10	,	,	PUNCT
fnp-5337	91	11	burbano	burbano	PROPN
fnp-5337	91	12	rmr	rmr	PROPN
fnp-5337	91	13	,	,	PUNCT
fnp-5337	91	14	de	de	PROPN
fnp-5337	91	15	moraes	moraes	PROPN
fnp-5337	91	16	filho	filho	PROPN
fnp-5337	91	17	mo	mo	PROPN
fnp-5337	91	18	,	,	PUNCT
fnp-5337	91	19	rabenhorst	rabenhorst	ADJ
fnp-5337	91	20	shb	shb	PROPN
fnp-5337	91	21	.	.	PUNCT
fnp-5337	92	1	tp53	tp53	PROPN
fnp-5337	92	2	mutations	mutation	NOUN
fnp-5337	92	3	in	in	ADP
fnp-5337	92	4	astrocytic	astrocytic	ADJ
fnp-5337	92	5	gliomas	glioma	NOUN
fnp-5337	92	6	:	:	PUNCT
fnp-5337	92	7	an	an	DET
fnp-5337	92	8	association	association	NOUN
fnp-5337	92	9	with	with	ADP
fnp-5337	92	10	histological	histological	ADJ
fnp-5337	92	11	grade	grade	NOUN
fnp-5337	92	12	,	,	PUNCT
fnp-5337	92	13	tp53	tp53	PROPN
fnp-5337	92	14	codon	codon	NOUN
fnp-5337	92	15	72	72	NUM
fnp-5337	92	16	polymorphism	polymorphism	NOUN
fnp-5337	92	17	and	and	CCONJ
fnp-5337	92	18	p53	p53	NOUN
fnp-5337	92	19	expression	expression	NOUN
fnp-5337	92	20	.	.	PUNCT
fnp-5337	93	1	apmis	apmis	PROPN
fnp-5337	94	1	[	[	X
fnp-5337	94	2	internet	internet	NOUN
fnp-5337	94	3	]	]	PUNCT
fnp-5337	94	4	2012	2012	NUM
fnp-5337	94	5	[	[	X
fnp-5337	94	6	cited	cite	VERB
fnp-5337	94	7	2023	2023	NUM
fnp-5337	94	8	mar	mar	PROPN
fnp-5337	94	9	4];120(11):882–9	4];120(11):882–9	PROPN
fnp-5337	94	10	.	.	PUNCT
fnp-5337	95	1	https://doi.org/10.1111/j.1600-0463.2012.02918.x	https://doi.org/10.1111/j.1600-0463.2012.02918.x	NOUN
fnp-5337	95	2	11	11	NUM
fnp-5337	95	3	.	.	PUNCT
fnp-5337	96	1	gillet	gillet	PROPN
fnp-5337	96	2	e	e	PROPN
fnp-5337	96	3	,	,	PUNCT
fnp-5337	96	4	alentorn	alentorn	VERB
fnp-5337	96	5	a	a	PRON
fnp-5337	96	6	,	,	PUNCT
fnp-5337	96	7	doukouré	doukouré	NOUN
fnp-5337	96	8	b	b	NOUN
fnp-5337	96	9	,	,	PUNCT
fnp-5337	96	10	et	et	PROPN
fnp-5337	96	11	al	al	PROPN
fnp-5337	96	12	.	.	PUNCT
fnp-5337	97	1	tp53	tp53	PROPN
fnp-5337	97	2	and	and	CCONJ
fnp-5337	97	3	p53	p53	NOUN
fnp-5337	97	4	statuses	status	NOUN
fnp-5337	97	5	and	and	CCONJ
fnp-5337	97	6	their	their	PRON
fnp-5337	97	7	clinical	clinical	ADJ
fnp-5337	97	8	impact	impact	NOUN
fnp-5337	97	9	in	in	ADP
fnp-5337	97	10	diffuse	diffuse	ADJ
fnp-5337	97	11	low	low	ADJ
fnp-5337	97	12	grade	grade	NOUN
fnp-5337	97	13	gliomas	glioma	NOUN
fnp-5337	97	14	.	.	PUNCT
fnp-5337	98	1	j	j	PROPN
fnp-5337	98	2	neurooncol	neurooncol	PROPN
fnp-5337	99	1	[	[	X
fnp-5337	99	2	internet	internet	NOUN
fnp-5337	99	3	]	]	PUNCT
fnp-5337	99	4	2014	2014	NUM
fnp-5337	100	1	[	[	X
fnp-5337	100	2	cited	cite	VERB
fnp-5337	100	3	2023	2023	NUM
fnp-5337	100	4	mar	mar	PROPN
fnp-5337	100	5	4];118(1):131–9	4];118(1):131–9	PROPN
fnp-5337	100	6	.	.	PUNCT
fnp-5337	101	1	https://doi.org/10.1007/s11060-014-1407-4	https://doi.org/10.1007/s11060-014-1407-4	NUM
fnp-5337	101	2	12	12	NUM
fnp-5337	101	3	.	.	PUNCT
fnp-5337	102	1	takami	takami	NOUN
fnp-5337	102	2	h	h	PROPN
fnp-5337	102	3	,	,	PUNCT
fnp-5337	102	4	yoshida	yoshida	PROPN
fnp-5337	102	5	a	a	PROPN
fnp-5337	102	6	,	,	PUNCT
fnp-5337	102	7	fukushima	fukushima	PROPN
fnp-5337	102	8	s	s	PROPN
fnp-5337	102	9	,	,	PUNCT
fnp-5337	102	10	et	et	PROPN
fnp-5337	102	11	al	al	PROPN
fnp-5337	102	12	.	.	PUNCT
fnp-5337	102	13	revisiting	revisit	VERB
fnp-5337	102	14	tp53	tp53	PROPN
fnp-5337	102	15	mutations	mutation	NOUN
fnp-5337	102	16	and	and	CCONJ
fnp-5337	102	17	immunohistochemistry	immunohistochemistry	NOUN
fnp-5337	102	18	-	-	PUNCT
fnp-5337	102	19	a	a	DET
fnp-5337	102	20	comparative	comparative	ADJ
fnp-5337	102	21	study	study	NOUN
fnp-5337	102	22	in	in	ADP
fnp-5337	102	23	157	157	NUM
fnp-5337	102	24	diffuse	diffuse	NOUN
fnp-5337	102	25	gliomas	glioma	NOUN
fnp-5337	102	26	.	.	PUNCT
fnp-5337	103	1	brain	brain	NOUN
fnp-5337	103	2	pathol	pathol	NOUN
fnp-5337	103	3	[	[	X
fnp-5337	103	4	internet	internet	NOUN
fnp-5337	103	5	]	]	PUNCT
fnp-5337	103	6	2015	2015	NUM
fnp-5337	104	1	[	[	X
fnp-5337	104	2	cited	cite	VERB
fnp-5337	104	3	2023	2023	NUM
fnp-5337	104	4	mar	mar	PROPN
fnp-5337	104	5	4];25(3):256–65	4];25(3):256–65	PROPN
fnp-5337	104	6	.	.	PUNCT
fnp-5337	105	1	https://doi.org/10.1111/bpa.12173	https://doi.org/10.1111/bpa.12173	PROPN
fnp-5337	105	2	13	13	NUM
fnp-5337	105	3	.	.	PUNCT
fnp-5337	106	1	oka	oka	PROPN
fnp-5337	106	2	h	h	PROPN
fnp-5337	106	3	,	,	PUNCT
fnp-5337	106	4	utsuki	utsuki	PROPN
fnp-5337	106	5	s	s	PART
fnp-5337	106	6	,	,	PUNCT
fnp-5337	106	7	tanizaki	tanizaki	PROPN
fnp-5337	106	8	y	y	PROPN
fnp-5337	106	9	,	,	PUNCT
fnp-5337	106	10	et	et	PROPN
fnp-5337	106	11	al	al	PROPN
fnp-5337	106	12	.	.	PROPN
fnp-5337	106	13	clinicopathological	clinicopathological	ADJ
fnp-5337	106	14	features	feature	NOUN
fnp-5337	106	15	of	of	ADP
fnp-5337	106	16	human	human	ADJ
fnp-5337	106	17	brainstem	brainstem	NOUN
fnp-5337	106	18	gliomas	glioma	NOUN
fnp-5337	106	19	.	.	PUNCT
fnp-5337	107	1	brain	brain	NOUN
fnp-5337	107	2	tumor	tumor	NOUN
fnp-5337	107	3	pathol	pathol	NOUN
fnp-5337	107	4	[	[	X
fnp-5337	107	5	internet	internet	NOUN
fnp-5337	107	6	]	]	PUNCT
fnp-5337	107	7	2013	2013	NUM
fnp-5337	108	1	[	[	X
fnp-5337	108	2	cited	cite	VERB
fnp-5337	108	3	2023	2023	NUM
fnp-5337	108	4	mar	mar	PROPN
fnp-5337	108	5	4];30(1):1–7	4];30(1):1–7	PROPN
fnp-5337	108	6	.	.	PUNCT
fnp-5337	108	7	https://doi.org/10.1007/s10014-012-0099-8	https://doi.org/10.1007/s10014-012-0099-8	NUM
fnp-5337	108	8	14	14	NUM
fnp-5337	108	9	.	.	PUNCT
fnp-5337	109	1	lucas	lucas	PROPN
fnp-5337	109	2	chg	chg	PROPN
fnp-5337	109	3	,	,	PUNCT
fnp-5337	109	4	solomon	solomon	PROPN
fnp-5337	109	5	da	da	PROPN
fnp-5337	109	6	,	,	PUNCT
fnp-5337	109	7	perry	perry	PROPN
fnp-5337	109	8	a.	a.	PROPN
fnp-5337	109	9	a	a	DET
fnp-5337	109	10	review	review	NOUN
fnp-5337	109	11	of	of	ADP
fnp-5337	109	12	recently	recently	ADV
fnp-5337	109	13	described	describe	VERB
fnp-5337	109	14	genetic	genetic	ADJ
fnp-5337	109	15	alterations	alteration	NOUN
fnp-5337	109	16	in	in	ADP
fnp-5337	109	17	central	central	ADJ
fnp-5337	109	18	nervous	nervous	ADJ
fnp-5337	109	19	system	system	NOUN
fnp-5337	109	20	tumors	tumor	NOUN
fnp-5337	109	21	.	.	PUNCT
fnp-5337	110	1	hum	hum	PROPN
fnp-5337	110	2	pathol	pathol	PROPN
fnp-5337	110	3	[	[	X
fnp-5337	110	4	internet	internet	NOUN
fnp-5337	110	5	]	]	PUNCT
fnp-5337	110	6	2020	2020	NUM
fnp-5337	111	1	[	[	X
fnp-5337	111	2	cited	cite	VERB
fnp-5337	111	3	2023	2023	NUM
fnp-5337	111	4	mar	mar	PROPN
fnp-5337	111	5	4];96:56–66	4];96:56–66	NUM
fnp-5337	111	6	.	.	PUNCT
fnp-5337	112	1	https://doi.org/10.1016/j.humpath.2019.10.009	https://doi.org/10.1016/j.humpath.2019.10.009	NOUN
fnp-5337	112	2	15	15	NUM
fnp-5337	112	3	.	.	PUNCT
fnp-5337	113	1	chenn	chenn	PROPN
fnp-5337	113	2	a	a	PRON
fnp-5337	113	3	,	,	PUNCT
fnp-5337	113	4	parker	parker	PROPN
fnp-5337	113	5	s	s	PROPN
fnp-5337	113	6	,	,	PUNCT
fnp-5337	113	7	degeare	degeare	NOUN
fnp-5337	113	8	sp	sp	NOUN
fnp-5337	113	9	,	,	PUNCT
fnp-5337	113	10	et	et	PROPN
fnp-5337	113	11	al	al	PROPN
fnp-5337	113	12	.	.	PUNCT
fnp-5337	114	1	path-05	path-05	PROPN
fnp-5337	114	2	.	.	PROPN
fnp-5337	114	3	implementation	implementation	NOUN
fnp-5337	114	4	of	of	ADP
fnp-5337	114	5	a	a	DET
fnp-5337	114	6	targeted	target	VERB
fnp-5337	114	7	next	next	ADJ
fnp-5337	114	8	-	-	PUNCT
fnp-5337	114	9	generation	generation	NOUN
fnp-5337	114	10	sequencing	sequence	VERB
fnp-5337	114	11	panel	panel	NOUN
fnp-5337	114	12	for	for	ADP
fnp-5337	114	13	the	the	DET
fnp-5337	114	14	diagnosis	diagnosis	NOUN
fnp-5337	114	15	and	and	CCONJ
fnp-5337	114	16	precision	precision	NOUN
fnp-5337	114	17	medicine	medicine	NOUN
fnp-5337	114	18	treatment	treatment	NOUN
fnp-5337	114	19	of	of	ADP
fnp-5337	114	20	adult	adult	NOUN
fnp-5337	114	21	patients	patient	NOUN
fnp-5337	114	22	with	with	ADP
fnp-5337	114	23	who	who	PRON
fnp-5337	114	24	grade	grade	NOUN
fnp-5337	114	25	iv	iv	NUM
fnp-5337	114	26	diffuse	diffuse	NOUN
fnp-5337	114	27	gliomas	glioma	NOUN
fnp-5337	114	28	.	.	PUNCT
fnp-5337	115	1	neuro	neuro	PROPN
fnp-5337	115	2	oncol	oncol	PROPN
fnp-5337	116	1	[	[	X
fnp-5337	116	2	internet	internet	NOUN
fnp-5337	116	3	]	]	PUNCT
fnp-5337	116	4	2018	2018	NUM
fnp-5337	117	1	[	[	X
fnp-5337	117	2	cited	cite	VERB
fnp-5337	117	3	2023	2023	NUM
fnp-5337	117	4	mar	mar	PROPN
fnp-5337	117	5	4];20(suppl_6):vi158–9	4];20(suppl_6):vi158–9	NUM
fnp-5337	117	6	.	.	PUNCT
fnp-5337	118	1	https://doi.org/10.1093/neuonc/noy148.661	https://doi.org/10.1093/neuonc/noy148.661	PROPN
fnp-5337	118	2	16	16	NUM
fnp-5337	118	3	.	.	PUNCT
fnp-5337	119	1	kline	kline	PROPN
fnp-5337	119	2	cn	cn	PROPN
fnp-5337	119	3	,	,	PUNCT
fnp-5337	119	4	joseph	joseph	PROPN
fnp-5337	119	5	nm	nm	PROPN
fnp-5337	119	6	,	,	PUNCT
fnp-5337	119	7	grenert	grenert	PROPN
fnp-5337	119	8	jp	jp	NOUN
fnp-5337	119	9	,	,	PUNCT
fnp-5337	119	10	et	et	PROPN
fnp-5337	119	11	al	al	PROPN
fnp-5337	119	12	.	.	PROPN
fnp-5337	119	13	targeted	target	VERB
fnp-5337	119	14	next	next	ADJ
fnp-5337	119	15	-	-	PUNCT
fnp-5337	119	16	generation	generation	NOUN
fnp-5337	119	17	sequencing	sequencing	NOUN
fnp-5337	119	18	of	of	ADP
fnp-5337	119	19	pediatric	pediatric	ADJ
fnp-5337	119	20	neuro	neuro	NOUN
fnp-5337	119	21	-	-	PUNCT
fnp-5337	119	22	oncology	oncology	NOUN
fnp-5337	119	23	patients	patient	NOUN
fnp-5337	119	24	improves	improve	VERB
fnp-5337	119	25	diagnosis	diagnosis	NOUN
fnp-5337	119	26	,	,	PUNCT
fnp-5337	119	27	identifies	identify	VERB
fnp-5337	119	28	pathogenic	pathogenic	ADJ
fnp-5337	119	29	germline	germline	NOUN
fnp-5337	119	30	mutations	mutation	NOUN
fnp-5337	119	31	,	,	PUNCT
fnp-5337	119	32	and	and	CCONJ
fnp-5337	119	33	directs	direct	VERB
fnp-5337	119	34	targeted	targeted	ADJ
fnp-5337	119	35	therapy	therapy	NOUN
fnp-5337	119	36	.	.	PUNCT
fnp-5337	120	1	neuro	neuro	PROPN
fnp-5337	120	2	oncol	oncol	PROPN
fnp-5337	121	1	[	[	X
fnp-5337	121	2	internet	internet	NOUN
fnp-5337	121	3	]	]	PUNCT
fnp-5337	121	4	2017	2017	NUM
fnp-5337	121	5	[	[	X
fnp-5337	121	6	cited	cite	VERB
fnp-5337	121	7	2023	2023	NUM
fnp-5337	121	8	mar	mar	PROPN
fnp-5337	121	9	4];19(5):699–709	4];19(5):699–709	PROPN
fnp-5337	121	10	.	.	PUNCT
fnp-5337	122	1	https://doi.org/10.1093/neuonc/now254	https://doi.org/10.1093/neuonc/now254	PROPN
fnp-5337	122	2	copyright	copyright	NOUN
fnp-5337	122	3	:	:	PUNCT
fnp-5337	122	4	©	©	PROPN
fnp-5337	122	5	2024	2024	NUM
fnp-5337	122	6	the	the	DET
fnp-5337	122	7	author(s	author(s	NOUN
fnp-5337	122	8	)	)	PUNCT
fnp-5337	122	9	.	.	PUNCT
fnp-5337	123	1	this	this	PRON
fnp-5337	123	2	is	be	AUX
fnp-5337	123	3	an	an	DET
fnp-5337	123	4	open	open	ADJ
fnp-5337	123	5	access	access	NOUN
fnp-5337	123	6	article	article	NOUN
fnp-5337	123	7	distributed	distribute	VERB
fnp-5337	123	8	under	under	ADP
fnp-5337	123	9	the	the	DET
fnp-5337	123	10	terms	term	NOUN
fnp-5337	123	11	of	of	ADP
fnp-5337	123	12	the	the	DET
fnp-5337	123	13	creative	creative	ADJ
fnp-5337	123	14	commons	common	NOUN
fnp-5337	123	15	attribution	attribution	NOUN
fnp-5337	123	16	4.0	4.0	NUM
fnp-5337	123	17	international	international	ADJ
fnp-5337	123	18	license	license	NOUN
fnp-5337	123	19	(	(	PUNCT
fnp-5337	123	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-5337	123	21	)	)	PUNCT
fnp-5337	123	22	,	,	PUNCT
fnp-5337	123	23	which	which	PRON
fnp-5337	123	24	permits	permit	VERB
fnp-5337	123	25	unrestricted	unrestricted	ADJ
fnp-5337	123	26	use	use	NOUN
fnp-5337	123	27	,	,	PUNCT
fnp-5337	123	28	distribution	distribution	NOUN
fnp-5337	123	29	,	,	PUNCT
fnp-5337	123	30	and	and	CCONJ
fnp-5337	123	31	reproduction	reproduction	NOUN
fnp-5337	123	32	in	in	ADP
fnp-5337	123	33	any	any	DET
fnp-5337	123	34	medium	medium	NOUN
fnp-5337	123	35	,	,	PUNCT
fnp-5337	123	36	provided	provide	VERB
fnp-5337	123	37	the	the	DET
fnp-5337	123	38	original	original	ADJ
fnp-5337	123	39	author	author	NOUN
fnp-5337	123	40	and	and	CCONJ
fnp-5337	123	41	source	source	NOUN
fnp-5337	123	42	are	be	AUX
fnp-5337	123	43	credited	credit	VERB
fnp-5337	123	44	,	,	PUNCT
fnp-5337	123	45	a	a	DET
fnp-5337	123	46	link	link	NOUN
fnp-5337	123	47	to	to	ADP
fnp-5337	123	48	the	the	DET
fnp-5337	123	49	creative	creative	ADJ
fnp-5337	123	50	commons	common	NOUN
fnp-5337	123	51	license	license	NOUN
fnp-5337	123	52	is	be	AUX
fnp-5337	123	53	provided	provide	VERB
fnp-5337	123	54	,	,	PUNCT
fnp-5337	123	55	and	and	CCONJ
fnp-5337	123	56	any	any	DET
fnp-5337	123	57	changes	change	NOUN
fnp-5337	123	58	are	be	AUX
fnp-5337	123	59	indicated	indicate	VERB
fnp-5337	123	60	.	.	PUNCT
fnp-5337	124	1	the	the	DET
fnp-5337	124	2	creative	creative	ADJ
fnp-5337	124	3	commons	common	NOUN
fnp-5337	124	4	public	public	ADJ
fnp-5337	124	5	domain	domain	NOUN
fnp-5337	124	6	dedication	dedication	NOUN
fnp-5337	124	7	waiver	waiver	NOUN
fnp-5337	124	8	(	(	PUNCT
fnp-5337	124	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-5337	124	10	)	)	PUNCT
fnp-5337	124	11	applies	apply	VERB
fnp-5337	124	12	to	to	ADP
fnp-5337	124	13	the	the	DET
fnp-5337	124	14	data	datum	NOUN
fnp-5337	124	15	made	make	VERB
fnp-5337	124	16	available	available	ADJ
fnp-5337	124	17	in	in	ADP
fnp-5337	124	18	this	this	DET
fnp-5337	124	19	article	article	NOUN
fnp-5337	124	20	,	,	PUNCT
fnp-5337	124	21	unless	unless	SCONJ
fnp-5337	124	22	otherwise	otherwise	ADV
fnp-5337	124	23	stated	state	VERB
fnp-5337	124	24	.	.	PUNCT