id	sid	tid	token	lemma	pos
fnp-5377	1	1	malignant	malignant	ADJ
fnp-5377	1	2	glioma	glioma	NOUN
fnp-5377	1	3	in	in	ADP
fnp-5377	1	4	l-2	l-2	PROPN
fnp-5377	1	5	-	-	PUNCT
fnp-5377	1	6	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	1	7	aciduria	aciduria	NOUN
fnp-5377	1	8	:	:	PUNCT
fnp-5377	1	9	thorough	thorough	ADJ
fnp-5377	1	10	molecular	molecular	ADJ
fnp-5377	1	11	characterization	characterization	NOUN
fnp-5377	1	12	of	of	ADP
fnp-5377	1	13	a	a	DET
fnp-5377	1	14	case	case	NOUN
fnp-5377	1	15	and	and	CCONJ
fnp-5377	1	16	literature	literature	NOUN
fnp-5377	1	17	review	review	NOUN
fnp-5377	1	18	free	free	ADJ
fnp-5377	1	19	neuropathology	neuropathology	NOUN
fnp-5377	1	20	5:11	5:11	NUM
fnp-5377	1	21	(	(	PUNCT
fnp-5377	1	22	2024	2024	NUM
fnp-5377	1	23	)	)	PUNCT
fnp-5377	1	24	case	case	NOUN
fnp-5377	1	25	report	report	VERB
fnp-5377	1	26	malignant	malignant	ADJ
fnp-5377	1	27	glioma	glioma	NOUN
fnp-5377	1	28	in	in	ADP
fnp-5377	1	29	l-2	l-2	PROPN
fnp-5377	1	30	-	-	PUNCT
fnp-5377	1	31	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	1	32	aciduria	aciduria	NOUN
fnp-5377	1	33	:	:	PUNCT
fnp-5377	1	34	thorough	thorough	ADJ
fnp-5377	1	35	molecular	molecular	ADJ
fnp-5377	1	36	characterization	characterization	NOUN
fnp-5377	1	37	of	of	ADP
fnp-5377	1	38	a	a	DET
fnp-5377	1	39	case	case	NOUN
fnp-5377	1	40	and	and	CCONJ
fnp-5377	1	41	literature	literature	NOUN
fnp-5377	1	42	review	review	PROPN
fnp-5377	1	43	fleur	fleur	PROPN
fnp-5377	1	44	cordier1,2	cordier1,2	PROPN
fnp-5377	1	45	,	,	PUNCT
fnp-5377	1	46	pieter	pieter	PROPN
fnp-5377	1	47	wesseling1,3	wesseling1,3	PROPN
fnp-5377	1	48	,	,	PUNCT
fnp-5377	1	49	bastiaan	bastiaan	PROPN
fnp-5377	1	50	b.j	b.j	PROPN
fnp-5377	1	51	.	.	PUNCT
fnp-5377	2	1	tops1	tops1	PROPN
fnp-5377	2	2	,	,	PUNCT
fnp-5377	2	3	lennart	lennart	PROPN
fnp-5377	2	4	kester1	kester1	PROPN
fnp-5377	2	5	,	,	PUNCT
fnp-5377	2	6	pim	pim	PROPN
fnp-5377	2	7	j.	j.	PROPN
fnp-5377	2	8	french4	french4	PROPN
fnp-5377	2	9	,	,	PUNCT
fnp-5377	2	10	martin	martin	PROPN
fnp-5377	2	11	van	van	PROPN
fnp-5377	2	12	den	den	PROPN
fnp-5377	2	13	bent4	bent4	PROPN
fnp-5377	2	14	,	,	PUNCT
fnp-5377	2	15	felix	felix	PROPN
fnp-5377	2	16	hinz5,11	hinz5,11	PROPN
fnp-5377	2	17	,	,	PUNCT
fnp-5377	2	18	eleonora	eleonora	PROPN
fnp-5377	2	19	aronica3	aronica3	PROPN
fnp-5377	2	20	,	,	PUNCT
fnp-5377	2	21	k.	k.	PROPN
fnp-5377	2	22	mariam	mariam	PROPN
fnp-5377	2	23	slot6	slot6	PROPN
fnp-5377	2	24	,	,	PUNCT
fnp-5377	2	25	floor	floor	NOUN
fnp-5377	2	26	abbink7	abbink7	NOUN
fnp-5377	2	27	,	,	PUNCT
fnp-5377	2	28	marjo	marjo	NOUN
fnp-5377	2	29	s.	s.	PROPN
fnp-5377	2	30	van	van	PROPN
fnp-5377	2	31	der	der	PROPN
fnp-5377	2	32	knaap8,9,10	knaap8,9,10	PROPN
fnp-5377	2	33	,	,	PUNCT
fnp-5377	2	34	mariëtte	mariëtte	NOUN
fnp-5377	2	35	e.g.	e.g.	ADV
fnp-5377	2	36	kranendonk1	kranendonk1	ADJ
fnp-5377	2	37	princess	princess	NOUN
fnp-5377	2	38	máxima	máxima	PROPN
fnp-5377	2	39	center	center	NOUN
fnp-5377	2	40	for	for	ADP
fnp-5377	2	41	pediatric	pediatric	ADJ
fnp-5377	2	42	oncology	oncology	NOUN
fnp-5377	2	43	,	,	PUNCT
fnp-5377	2	44	utrecht	utrecht	PROPN
fnp-5377	2	45	,	,	PUNCT
fnp-5377	2	46	the	the	DET
fnp-5377	2	47	netherlands	netherlands	PROPN
fnp-5377	2	48	department	department	PROPN
fnp-5377	2	49	of	of	ADP
fnp-5377	2	50	pathology	pathology	PROPN
fnp-5377	2	51	,	,	PUNCT
fnp-5377	2	52	ghent	ghent	PROPN
fnp-5377	2	53	university	university	NOUN
fnp-5377	2	54	hospital	hospital	NOUN
fnp-5377	2	55	,	,	PUNCT
fnp-5377	2	56	ghent	ghent	PROPN
fnp-5377	2	57	university	university	PROPN
fnp-5377	2	58	,	,	PUNCT
fnp-5377	2	59	ghent	ghent	NOUN
fnp-5377	2	60	,	,	PUNCT
fnp-5377	2	61	belgium	belgium	PROPN
fnp-5377	2	62	department	department	PROPN
fnp-5377	2	63	of	of	ADP
fnp-5377	2	64	pathology	pathology	PROPN
fnp-5377	2	65	,	,	PUNCT
fnp-5377	2	66	amsterdam	amsterdam	PROPN
fnp-5377	2	67	university	university	PROPN
fnp-5377	2	68	medical	medical	ADJ
fnp-5377	2	69	centers	center	NOUN
fnp-5377	2	70	(	(	PUNCT
fnp-5377	2	71	umc	umc	PROPN
fnp-5377	2	72	)	)	PUNCT
fnp-5377	2	73	,	,	PUNCT
fnp-5377	2	74	university	university	NOUN
fnp-5377	2	75	of	of	ADP
fnp-5377	2	76	amsterdam	amsterdam	PROPN
fnp-5377	2	77	(	(	PUNCT
fnp-5377	2	78	ea	ea	NOUN
fnp-5377	2	79	)	)	PUNCT
fnp-5377	2	80	and	and	CCONJ
fnp-5377	2	81	vrije	vrije	PROPN
fnp-5377	2	82	universiteit	universiteit	PROPN
fnp-5377	2	83	amsterdam	amsterdam	PROPN
fnp-5377	2	84	(	(	PUNCT
fnp-5377	2	85	pw	pw	PROPN
fnp-5377	2	86	)	)	PUNCT
fnp-5377	2	87	,	,	PUNCT
fnp-5377	2	88	amsterdam	amsterdam	PROPN
fnp-5377	2	89	neuroscience	neuroscience	PROPN
fnp-5377	2	90	,	,	PUNCT
fnp-5377	2	91	the	the	DET
fnp-5377	2	92	netherlands	netherlands	PROPN
fnp-5377	2	93	department	department	PROPN
fnp-5377	2	94	of	of	ADP
fnp-5377	2	95	neurology	neurology	NOUN
fnp-5377	2	96	,	,	PUNCT
fnp-5377	2	97	erasmus	erasmus	PROPN
fnp-5377	2	98	medical	medical	ADJ
fnp-5377	2	99	center	center	PROPN
fnp-5377	2	100	,	,	PUNCT
fnp-5377	2	101	rotterdam	rotterdam	PROPN
fnp-5377	2	102	,	,	PUNCT
fnp-5377	2	103	the	the	DET
fnp-5377	2	104	netherlands	netherlands	PROPN
fnp-5377	2	105	department	department	PROPN
fnp-5377	2	106	of	of	ADP
fnp-5377	2	107	neuropathology	neuropathology	PROPN
fnp-5377	2	108	,	,	PUNCT
fnp-5377	2	109	institute	institute	PROPN
fnp-5377	2	110	of	of	ADP
fnp-5377	2	111	pathology	pathology	PROPN
fnp-5377	2	112	,	,	PUNCT
fnp-5377	2	113	heidelberg	heidelberg	PROPN
fnp-5377	2	114	university	university	PROPN
fnp-5377	2	115	hospital	hospital	NOUN
fnp-5377	2	116	,	,	PUNCT
fnp-5377	2	117	heidelberg	heidelberg	PROPN
fnp-5377	2	118	,	,	PUNCT
fnp-5377	2	119	germany	germany	PROPN
fnp-5377	2	120	department	department	PROPN
fnp-5377	2	121	of	of	ADP
fnp-5377	2	122	neurosurgery	neurosurgery	PROPN
fnp-5377	2	123	,	,	PUNCT
fnp-5377	2	124	amsterdam	amsterdam	PROPN
fnp-5377	2	125	university	university	PROPN
fnp-5377	2	126	medical	medical	ADJ
fnp-5377	2	127	centers	center	NOUN
fnp-5377	2	128	,	,	PUNCT
fnp-5377	2	129	amsterdam	amsterdam	PROPN
fnp-5377	2	130	,	,	PUNCT
fnp-5377	2	131	the	the	DET
fnp-5377	2	132	netherlands	netherlands	PROPN
fnp-5377	2	133	department	department	PROPN
fnp-5377	2	134	of	of	ADP
fnp-5377	2	135	pediatric	pediatric	ADJ
fnp-5377	2	136	oncology	oncology	NOUN
fnp-5377	2	137	,	,	PUNCT
fnp-5377	2	138	emma	emma	PROPN
fnp-5377	2	139	children	children	PROPN
fnp-5377	2	140	's	's	PART
fnp-5377	2	141	hospital	hospital	NOUN
fnp-5377	2	142	,	,	PUNCT
fnp-5377	2	143	amsterdam	amsterdam	PROPN
fnp-5377	2	144	university	university	PROPN
fnp-5377	2	145	medical	medical	ADJ
fnp-5377	2	146	centers	center	NOUN
fnp-5377	2	147	,	,	PUNCT
fnp-5377	2	148	amsterdam	amsterdam	PROPN
fnp-5377	2	149	,	,	PUNCT
fnp-5377	2	150	the	the	DET
fnp-5377	2	151	netherlands	netherlands	PROPN
fnp-5377	2	152	department	department	PROPN
fnp-5377	2	153	of	of	ADP
fnp-5377	2	154	pediatric	pediatric	ADJ
fnp-5377	2	155	neurology	neurology	NOUN
fnp-5377	2	156	,	,	PUNCT
fnp-5377	2	157	emma	emma	PROPN
fnp-5377	2	158	children	children	PROPN
fnp-5377	2	159	's	's	PART
fnp-5377	2	160	hospital	hospital	NOUN
fnp-5377	2	161	,	,	PUNCT
fnp-5377	2	162	amsterdam	amsterdam	PROPN
fnp-5377	2	163	university	university	PROPN
fnp-5377	2	164	medical	medical	ADJ
fnp-5377	2	165	centers	center	NOUN
fnp-5377	2	166	,	,	PUNCT
fnp-5377	2	167	amsterdam	amsterdam	PROPN
fnp-5377	2	168	,	,	PUNCT
fnp-5377	2	169	the	the	DET
fnp-5377	2	170	netherlands	netherlands	PROPN
fnp-5377	2	171	amsterdam	amsterdam	PROPN
fnp-5377	2	172	neuroscience	neuroscience	PROPN
fnp-5377	2	173	,	,	PUNCT
fnp-5377	2	174	amsterdam	amsterdam	PROPN
fnp-5377	2	175	,	,	PUNCT
fnp-5377	2	176	the	the	DET
fnp-5377	2	177	netherlands	netherlands	PROPN
fnp-5377	2	178	department	department	PROPN
fnp-5377	2	179	of	of	ADP
fnp-5377	2	180	integrative	integrative	ADJ
fnp-5377	2	181	neurophysiology	neurophysiology	NOUN
fnp-5377	2	182	,	,	PUNCT
fnp-5377	2	183	center	center	NOUN
fnp-5377	2	184	for	for	ADP
fnp-5377	2	185	neurogenomics	neurogenomic	NOUN
fnp-5377	2	186	and	and	CCONJ
fnp-5377	2	187	cognitive	cognitive	ADJ
fnp-5377	2	188	research	research	NOUN
fnp-5377	2	189	,	,	PUNCT
fnp-5377	2	190	vrije	vrije	PROPN
fnp-5377	2	191	universiteit	universiteit	PROPN
fnp-5377	2	192	amsterdam	amsterdam	PROPN
fnp-5377	2	193	,	,	PUNCT
fnp-5377	2	194	amsterdam	amsterdam	PROPN
fnp-5377	2	195	,	,	PUNCT
fnp-5377	2	196	the	the	DET
fnp-5377	2	197	netherlands	netherlands	PROPN
fnp-5377	2	198	clinical	clinical	ADJ
fnp-5377	2	199	cooperation	cooperation	NOUN
fnp-5377	2	200	unit	unit	NOUN
fnp-5377	2	201	neuropathology	neuropathology	NOUN
fnp-5377	2	202	,	,	PUNCT
fnp-5377	2	203	german	german	ADJ
fnp-5377	2	204	consortium	consortium	NOUN
fnp-5377	2	205	for	for	ADP
fnp-5377	2	206	translational	translational	ADJ
fnp-5377	2	207	cancer	cancer	NOUN
fnp-5377	2	208	research	research	NOUN
fnp-5377	2	209	(	(	PUNCT
fnp-5377	2	210	dktk	dktk	NOUN
fnp-5377	2	211	)	)	PUNCT
fnp-5377	2	212	,	,	PUNCT
fnp-5377	2	213	german	german	ADJ
fnp-5377	2	214	cancer	cancer	NOUN
fnp-5377	2	215	research	research	NOUN
fnp-5377	2	216	center	center	NOUN
fnp-5377	2	217	(	(	PUNCT
fnp-5377	2	218	dkfz	dkfz	PROPN
fnp-5377	2	219	)	)	PUNCT
fnp-5377	2	220	,	,	PUNCT
fnp-5377	2	221	heidelberg	heidelberg	PROPN
fnp-5377	2	222	,	,	PUNCT
fnp-5377	2	223	germany	germany	PROPN
fnp-5377	2	224	corresponding	corresponding	ADJ
fnp-5377	2	225	authors	author	NOUN
fnp-5377	2	226	:	:	PUNCT
fnp-5377	2	227	marjo	marjo	PROPN
fnp-5377	2	228	s.	s.	PROPN
fnp-5377	2	229	van	van	PROPN
fnp-5377	2	230	der	der	PROPN
fnp-5377	2	231	knaap	knaap	PROPN
fnp-5377	2	232	&	&	CCONJ
fnp-5377	2	233	pieter	pieter	PROPN
fnp-5377	2	234	wesseling	wesseling	PROPN
fnp-5377	2	235	·	·	PUNCT
fnp-5377	2	236	dept	dept	PROPN
fnp-5377	2	237	.	.	PROPN
fnp-5377	2	238	of	of	ADP
fnp-5377	2	239	pediatric	pediatric	ADJ
fnp-5377	2	240	neurology	neurology	NOUN
fnp-5377	2	241	&	&	CCONJ
fnp-5377	2	242	pathology	pathology	PROPN
fnp-5377	2	243	·	·	PUNCT
fnp-5377	2	244	amsterdam	amsterdam	PROPN
fnp-5377	2	245	university	university	PROPN
fnp-5377	2	246	medical	medical	ADJ
fnp-5377	2	247	centers	center	NOUN
fnp-5377	2	248	/	/	SYM
fnp-5377	2	249	vumc	vumc	NOUN
fnp-5377	2	250	·	·	PUNCT
fnp-5377	2	251	de	de	X
fnp-5377	2	252	boelelaan	boelelaan	NOUN
fnp-5377	2	253	1117	1117	NUM
fnp-5377	2	254	·	·	SYM
fnp-5377	2	255	1081	1081	NUM
fnp-5377	2	256	hv	hv	PROPN
fnp-5377	2	257	amsterdam	amsterdam	PROPN
fnp-5377	2	258	·	·	PUNCT
fnp-5377	2	259	the	the	DET
fnp-5377	2	260	netherlands	netherlands	PROPN
fnp-5377	2	261	p.wesseling@amsterdamumc.nl	p.wesseling@amsterdamumc.nl	VERB
fnp-5377	2	262	submitted	submit	VERB
fnp-5377	2	263	:	:	PUNCT
fnp-5377	2	264	15	15	NUM
fnp-5377	2	265	february	february	NOUN
fnp-5377	2	266	2024	2024	NUM
fnp-5377	2	267	accepted	accept	VERB
fnp-5377	2	268	:	:	PUNCT
fnp-5377	2	269	23	23	NUM
fnp-5377	2	270	april	april	PROPN
fnp-5377	2	271	2024	2024	NUM
fnp-5377	2	272	copyedited	copyedit	VERB
fnp-5377	2	273	by	by	ADP
fnp-5377	2	274	:	:	PUNCT
fnp-5377	2	275	georg	georg	NOUN
fnp-5377	2	276	haase	haase	NOUN
fnp-5377	2	277	published	publish	VERB
fnp-5377	2	278	:	:	PUNCT
fnp-5377	2	279	3	3	NUM
fnp-5377	2	280	may	may	PROPN
fnp-5377	2	281	2024	2024	NUM
fnp-5377	2	282	https://doi.org/10.17879/freeneuropathology-2024-5377	https://doi.org/10.17879/freeneuropathology-2024-5377	ADP
fnp-5377	2	283	keywords	keyword	NOUN
fnp-5377	2	284	:	:	PUNCT
fnp-5377	2	285	l-2	l-2	PROPN
fnp-5377	2	286	-	-	PUNCT
fnp-5377	2	287	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	2	288	aciduria	aciduria	NOUN
fnp-5377	2	289	,	,	PUNCT
fnp-5377	2	290	cns	cns	PROPN
fnp-5377	2	291	tumor	tumor	NOUN
fnp-5377	2	292	,	,	PUNCT
fnp-5377	2	293	paediatric	paediatric	ADJ
fnp-5377	2	294	-	-	PUNCT
fnp-5377	2	295	type	type	NOUN
fnp-5377	2	296	diffuse	diffuse	NOUN
fnp-5377	2	297	high	high	ADJ
fnp-5377	2	298	-	-	PUNCT
fnp-5377	2	299	grade	grade	NOUN
fnp-5377	2	300	glioma	glioma	NOUN
fnp-5377	2	301	,	,	PUNCT
fnp-5377	2	302	dna	dna	NOUN
fnp-5377	2	303	-	-	PUNCT
fnp-5377	2	304	methylation	methylation	NOUN
fnp-5377	2	305	-	-	PUNCT
fnp-5377	2	306	classification	classification	NOUN
fnp-5377	2	307	,	,	PUNCT
fnp-5377	2	308	sequencing	sequence	VERB
fnp-5377	2	309	abstract	abstract	ADJ
fnp-5377	2	310	l-2	l-2	PROPN
fnp-5377	2	311	-	-	PUNCT
fnp-5377	2	312	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	2	313	aciduria	aciduria	NOUN
fnp-5377	2	314	(	(	PUNCT
fnp-5377	2	315	l-2	l-2	PROPN
fnp-5377	2	316	-	-	PUNCT
fnp-5377	2	317	hga	hga	PROPN
fnp-5377	2	318	)	)	PUNCT
fnp-5377	2	319	is	be	AUX
fnp-5377	2	320	a	a	DET
fnp-5377	2	321	rare	rare	ADJ
fnp-5377	2	322	neurometabolic	neurometabolic	ADJ
fnp-5377	2	323	disorder	disorder	NOUN
fnp-5377	2	324	characterized	characterize	VERB
fnp-5377	2	325	by	by	ADP
fnp-5377	2	326	accumulation	accumulation	NOUN
fnp-5377	2	327	of	of	ADP
fnp-5377	2	328	l2	l2	NOUN
fnp-5377	2	329	-	-	PUNCT
fnp-5377	2	330	hydroxyglutarate	hydroxyglutarate	NOUN
fnp-5377	2	331	(	(	PUNCT
fnp-5377	2	332	l-2	l-2	PROPN
fnp-5377	2	333	-	-	PUNCT
fnp-5377	2	334	hg	hg	NOUN
fnp-5377	2	335	)	)	PUNCT
fnp-5377	2	336	due	due	ADP
fnp-5377	2	337	to	to	ADP
fnp-5377	2	338	mutations	mutation	NOUN
fnp-5377	2	339	in	in	ADP
fnp-5377	2	340	the	the	DET
fnp-5377	2	341	l2hgdh	l2hgdh	ADJ
fnp-5377	2	342	gene	gene	NOUN
fnp-5377	2	343	.	.	PUNCT
fnp-5377	3	1	l-2	l-2	PROPN
fnp-5377	3	2	-	-	PUNCT
fnp-5377	3	3	hga	hga	PROPN
fnp-5377	3	4	patients	patient	NOUN
fnp-5377	3	5	have	have	VERB
fnp-5377	3	6	a	a	DET
fnp-5377	3	7	significantly	significantly	ADV
fnp-5377	3	8	increased	increase	VERB
fnp-5377	3	9	lifetime	lifetime	NOUN
fnp-5377	3	10	risk	risk	NOUN
fnp-5377	3	11	of	of	ADP
fnp-5377	3	12	central	central	ADJ
fnp-5377	3	13	nervous	nervous	ADJ
fnp-5377	3	14	system	system	NOUN
fnp-5377	3	15	(	(	PUNCT
fnp-5377	3	16	cns	cns	NOUN
fnp-5377	3	17	)	)	PUNCT
fnp-5377	3	18	tumors	tumor	NOUN
fnp-5377	3	19	.	.	PUNCT
fnp-5377	4	1	here	here	ADV
fnp-5377	4	2	,	,	PUNCT
fnp-5377	4	3	we	we	PRON
fnp-5377	4	4	present	present	VERB
fnp-5377	4	5	a	a	DET
fnp-5377	4	6	16	16	NUM
fnp-5377	4	7	-	-	PUNCT
fnp-5377	4	8	year	year	NOUN
fnp-5377	4	9	-	-	PUNCT
fnp-5377	4	10	old	old	ADJ
fnp-5377	4	11	girl	girl	NOUN
fnp-5377	4	12	with	with	ADP
fnp-5377	4	13	l-2	l-2	PROPN
fnp-5377	4	14	-	-	PUNCT
fnp-5377	4	15	hga	hga	PROPN
fnp-5377	4	16	who	who	PRON
fnp-5377	4	17	developed	develop	VERB
fnp-5377	4	18	a	a	DET
fnp-5377	4	19	tumor	tumor	NOUN
fnp-5377	4	20	in	in	ADP
fnp-5377	4	21	the	the	DET
fnp-5377	4	22	right	right	ADJ
fnp-5377	4	23	cerebral	cerebral	ADJ
fnp-5377	4	24	hemisphere	hemisphere	ADV
fnp-5377	4	25	,	,	PUNCT
fnp-5377	4	26	which	which	PRON
fnp-5377	4	27	was	be	AUX
fnp-5377	4	28	discovered	discover	VERB
fnp-5377	4	29	after	after	ADP
fnp-5377	4	30	left	left	ADJ
fnp-5377	4	31	-	-	PUNCT
fnp-5377	4	32	sided	sided	ADJ
fnp-5377	4	33	neurological	neurological	ADJ
fnp-5377	4	34	deficits	deficit	NOUN
fnp-5377	4	35	of	of	ADP
fnp-5377	4	36	the	the	DET
fnp-5377	4	37	patient	patient	NOUN
fnp-5377	4	38	.	.	PUNCT
fnp-5377	5	1	histologically	histologically	ADV
fnp-5377	5	2	,	,	PUNCT
fnp-5377	5	3	the	the	DET
fnp-5377	5	4	tumor	tumor	NOUN
fnp-5377	5	5	had	have	VERB
fnp-5377	5	6	a	a	DET
fnp-5377	5	7	high	high	ADJ
fnp-5377	5	8	-	-	PUNCT
fnp-5377	5	9	grade	grade	NOUN
fnp-5377	5	10	diffuse	diffuse	NOUN
fnp-5377	5	11	glioma	glioma	NOUN
fnp-5377	5	12	phenotype	phenotype	NOUN
fnp-5377	5	13	.	.	PUNCT
fnp-5377	6	1	dna	dna	PROPN
fnp-5377	6	2	sequencing	sequencing	NOUN
fnp-5377	6	3	revealed	reveal	VERB
fnp-5377	6	4	the	the	DET
fnp-5377	6	5	inactivating	inactivate	VERB
fnp-5377	6	6	homozygous	homozygous	ADJ
fnp-5377	6	7	germline	germline	NOUN
fnp-5377	6	8	l2hgdh	l2hgdh	NOUN
fnp-5377	6	9	mutation	mutation	NOUN
fnp-5377	6	10	as	as	ADV
fnp-5377	6	11	well	well	ADV
fnp-5377	6	12	as	as	ADP
fnp-5377	6	13	inactivating	inactivate	VERB
fnp-5377	6	14	mutations	mutation	NOUN
fnp-5377	6	15	in	in	ADP
fnp-5377	6	16	tp53	tp53	PROPN
fnp-5377	6	17	,	,	PUNCT
fnp-5377	6	18	bcor	bcor	NOUN
fnp-5377	6	19	and	and	CCONJ
fnp-5377	6	20	nf1	nf1	NOUN
fnp-5377	6	21	.	.	PUNCT
fnp-5377	7	1	genome	genome	NOUN
fnp-5377	7	2	-	-	PUNCT
fnp-5377	7	3	wide	wide	ADJ
fnp-5377	7	4	dna	dna	NOUN
fnp-5377	7	5	-	-	PUNCT
fnp-5377	7	6	methylation	methylation	NOUN
fnp-5377	7	7	analysis	analysis	NOUN
fnp-5377	7	8	was	be	AUX
fnp-5377	7	9	unable	unable	ADJ
fnp-5377	7	10	to	to	PART
fnp-5377	7	11	classify	classify	VERB
fnp-5377	7	12	the	the	DET
fnp-5377	7	13	tumor	tumor	NOUN
fnp-5377	7	14	with	with	ADP
fnp-5377	7	15	high	high	ADJ
fnp-5377	7	16	confidence	confidence	NOUN
fnp-5377	7	17	.	.	PUNCT
fnp-5377	8	1	more	more	ADV
fnp-5377	8	2	detailed	detailed	ADJ
fnp-5377	8	3	analysis	analysis	NOUN
fnp-5377	8	4	revealed	reveal	VERB
fnp-5377	8	5	that	that	SCONJ
fnp-5377	8	6	this	this	DET
fnp-5377	8	7	tumor	tumor	NOUN
fnp-5377	8	8	clustered	cluster	VERB
fnp-5377	8	9	amongst	amongst	ADP
fnp-5377	8	10	idh	idh	NOUN
fnp-5377	8	11	-	-	PUNCT
fnp-5377	8	12	wildtype	wildtype	NOUN
fnp-5377	8	13	gliomas	glioma	NOUN
fnp-5377	8	14	by	by	ADP
fnp-5377	8	15	methylation	methylation	NOUN
fnp-5377	8	16	profiling	profiling	NOUN
fnp-5377	8	17	and	and	CCONJ
fnp-5377	8	18	did	do	AUX
fnp-5377	8	19	not	not	PART
fnp-5377	8	20	show	show	VERB
fnp-5377	8	21	the	the	DET
fnp-5377	8	22	glioma	glioma	NOUN
fnp-5377	8	23	cpg	cpg	PROPN
fnp-5377	8	24	island	island	PROPN
fnp-5377	8	25	methylator	methylator	PROPN
fnp-5377	8	26	phenotype	phenotype	NOUN
fnp-5377	8	27	(	(	PUNCT
fnp-5377	8	28	g	g	NOUN
fnp-5377	8	29	-	-	PUNCT
fnp-5377	8	30	cimp	cimp	NOUN
fnp-5377	8	31	)	)	PUNCT
fnp-5377	8	32	in	in	ADP
fnp-5377	8	33	contrast	contrast	NOUN
fnp-5377	8	34	to	to	ADP
fnp-5377	8	35	idh	idh	NOUN
fnp-5377	8	36	-	-	PUNCT
fnp-5377	8	37	mutant	mutant	NOUN
fnp-5377	8	38	diffuse	diffuse	NOUN
fnp-5377	8	39	gliomas	glioma	NOUN
fnp-5377	8	40	with	with	ADP
fnp-5377	8	41	accumulated	accumulate	VERB
fnp-5377	8	42	levels	level	NOUN
fnp-5377	8	43	of	of	ADP
fnp-5377	8	44	d-2	d-2	NOUN
fnp-5377	8	45	-	-	PUNCT
fnp-5377	8	46	hg	hg	NOUN
fnp-5377	8	47	,	,	PUNCT
fnp-5377	8	48	the	the	DET
fnp-5377	8	49	stereoisomer	stereoisomer	NOUN
fnp-5377	8	50	of	of	ADP
fnp-5377	8	51	l-2	l-2	PROPN
fnp-5377	8	52	-	-	PUNCT
fnp-5377	8	53	hd	hd	PROPN
fnp-5377	8	54	.	.	PUNCT
fnp-5377	9	1	these	these	DET
fnp-5377	9	2	findings	finding	NOUN
fnp-5377	9	3	were	be	AUX
fnp-5377	9	4	against	against	ADP
fnp-5377	9	5	all	all	DET
fnp-5377	9	6	our	our	PRON
fnp-5377	9	7	expectations	expectation	NOUN
fnp-5377	9	8	given	give	VERB
fnp-5377	9	9	the	the	DET
fnp-5377	9	10	inhibitory	inhibitory	ADJ
fnp-5377	9	11	potential	potential	NOUN
fnp-5377	9	12	of	of	ADP
fnp-5377	9	13	2	2	NUM
fnp-5377	9	14	-	-	PUNCT
fnp-5377	9	15	hg	hg	NOUN
fnp-5377	9	16	on	on	ADP
fnp-5377	9	17	dna	dna	NOUN
fnp-5377	9	18	-	-	PUNCT
fnp-5377	9	19	demethylation	demethylation	NOUN
fnp-5377	9	20	enzymes	enzyme	NOUN
fnp-5377	9	21	.	.	PUNCT
fnp-5377	10	1	our	our	PRON
fnp-5377	10	2	final	final	ADJ
fnp-5377	10	3	integrated	integrated	ADJ
fnp-5377	10	4	histomolecular	histomolecular	ADJ
fnp-5377	10	5	diagnosis	diagnosis	NOUN
fnp-5377	10	6	of	of	ADP
fnp-5377	10	7	the	the	DET
fnp-5377	10	8	tumor	tumor	NOUN
fnp-5377	10	9	was	be	AUX
fnp-5377	10	10	diffuse	diffuse	ADJ
fnp-5377	10	11	pediatric	pediatric	ADJ
fnp-5377	10	12	-	-	PUNCT
fnp-5377	10	13	type	type	NOUN
fnp-5377	10	14	high	high	ADJ
fnp-5377	10	15	-	-	PUNCT
fnp-5377	10	16	grade	grade	NOUN
fnp-5377	10	17	glioma	glioma	NOUN
fnp-5377	10	18	,	,	PUNCT
fnp-5377	10	19	h3	h3	NOUN
fnp-5377	10	20	-	-	PUNCT
fnp-5377	10	21	wildtype	wildtype	NOUN
fnp-5377	10	22	and	and	CCONJ
fnp-5377	10	23	idh	idh	NOUN
fnp-5377	10	24	-	-	PUNCT
fnp-5377	10	25	wildtype	wildtype	NOUN
fnp-5377	10	26	.	.	PUNCT
fnp-5377	11	1	due	due	ADP
fnp-5377	11	2	to	to	ADP
fnp-5377	11	3	rapid	rapid	ADJ
fnp-5377	11	4	tumor	tumor	NOUN
fnp-5377	11	5	progression	progression	NOUN
fnp-5377	11	6	the	the	DET
fnp-5377	11	7	patient	patient	NOUN
fnp-5377	11	8	died	die	VERB
fnp-5377	11	9	nine	nine	NUM
fnp-5377	11	10	months	month	NOUN
fnp-5377	11	11	after	after	ADP
fnp-5377	11	12	initial	initial	ADJ
fnp-5377	11	13	diagnosis	diagnosis	NOUN
fnp-5377	11	14	.	.	PUNCT
fnp-5377	12	1	in	in	ADP
fnp-5377	12	2	this	this	DET
fnp-5377	12	3	manuscript	manuscript	NOUN
fnp-5377	12	4	,	,	PUNCT
fnp-5377	12	5	we	we	PRON
fnp-5377	12	6	provide	provide	VERB
fnp-5377	12	7	extensive	extensive	ADJ
fnp-5377	12	8	molecular	molecular	ADJ
fnp-5377	12	9	characterization	characterization	NOUN
fnp-5377	12	10	of	of	ADP
fnp-5377	12	11	the	the	DET
fnp-5377	12	12	tumor	tumor	NOUN
fnp-5377	12	13	as	as	ADV
fnp-5377	12	14	well	well	ADV
fnp-5377	12	15	as	as	ADP
fnp-5377	12	16	a	a	DET
fnp-5377	12	17	literature	literature	NOUN
fnp-5377	12	18	review	review	NOUN
fnp-5377	12	19	focusing	focus	VERB
fnp-5377	12	20	on	on	ADP
fnp-5377	12	21	oncogenetic	oncogenetic	ADJ
fnp-5377	12	22	considerations	consideration	NOUN
fnp-5377	12	23	of	of	ADP
fnp-5377	12	24	l-2	l-2	PROPN
fnp-5377	12	25	-	-	PUNCT
fnp-5377	12	26	hga	hga	PROPN
fnp-5377	12	27	-	-	PUNCT
fnp-5377	12	28	associated	associate	VERB
fnp-5377	12	29	cns	cns	NOUN
fnp-5377	12	30	tumors	tumor	NOUN
fnp-5377	12	31	.	.	PUNCT
fnp-5377	13	1	introduction	introduction	NOUN
fnp-5377	13	2	l-2	l-2	PROPN
fnp-5377	13	3	-	-	PUNCT
fnp-5377	13	4	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	13	5	aciduria	aciduria	NOUN
fnp-5377	13	6	(	(	PUNCT
fnp-5377	13	7	l-2	l-2	PROPN
fnp-5377	13	8	-	-	PUNCT
fnp-5377	13	9	hga	hga	PROPN
fnp-5377	13	10	)	)	PUNCT
fnp-5377	13	11	is	be	AUX
fnp-5377	13	12	an	an	DET
fnp-5377	13	13	autosomal	autosomal	ADJ
fnp-5377	13	14	recessive	recessive	ADJ
fnp-5377	13	15	neurometabolic	neurometabolic	NOUN
fnp-5377	13	16	disorder.1	disorder.1	NOUN
fnp-5377	13	17	the	the	DET
fnp-5377	13	18	disease	disease	NOUN
fnp-5377	13	19	is	be	AUX
fnp-5377	13	20	caused	cause	VERB
fnp-5377	13	21	by	by	ADP
fnp-5377	13	22	pathogenic	pathogenic	ADJ
fnp-5377	13	23	variants	variant	NOUN
fnp-5377	13	24	in	in	ADP
fnp-5377	13	25	the	the	DET
fnp-5377	13	26	l2hgdh	l2hgdh	ADJ
fnp-5377	13	27	gene	gene	NOUN
fnp-5377	13	28	(	(	PUNCT
fnp-5377	13	29	14q22.1	14q22.1	NUM
fnp-5377	13	30	)	)	PUNCT
fnp-5377	13	31	encoding	encode	VERB
fnp-5377	13	32	l-2	l-2	PROPN
fnp-5377	13	33	-	-	PUNCT
fnp-5377	13	34	hydroxyglutarate	hydroxyglutarate	PROPN
fnp-5377	13	35	dehydrogenase	dehydrogenase	NOUN
fnp-5377	13	36	,	,	PUNCT
fnp-5377	13	37	a	a	DET
fnp-5377	13	38	flavin	flavin	ADJ
fnp-5377	13	39	adenine	adenine	ADJ
fnp-5377	13	40	dinucleotide	dinucleotide	NOUN
fnp-5377	13	41	(	(	PUNCT
fnp-5377	13	42	fad)-dependent	fad)-dependent	ADJ
fnp-5377	13	43	enzyme	enzyme	NOUN
fnp-5377	13	44	that	that	PRON
fnp-5377	13	45	normally	normally	ADV
fnp-5377	13	46	oxidizes	oxidize	VERB
fnp-5377	13	47	l-2	l-2	PROPN
fnp-5377	13	48	-	-	PUNCT
fnp-5377	13	49	hydroxyglutarate	hydroxyglutarate	PROPN
fnp-5377	13	50	(	(	PUNCT
fnp-5377	13	51	l-2	l-2	PROPN
fnp-5377	13	52	-	-	PUNCT
fnp-5377	13	53	hg	hg	NOUN
fnp-5377	13	54	)	)	PUNCT
fnp-5377	13	55	to	to	ADP
fnp-5377	13	56	alpha	alpha	NOUN
fnp-5377	13	57	-	-	PUNCT
fnp-5377	13	58	ketoglutarate	ketoglutarate	NOUN
fnp-5377	13	59	.	.	PUNCT
fnp-5377	14	1	defective	defective	ADJ
fnp-5377	14	2	enzyme	enzyme	NOUN
fnp-5377	14	3	activity	activity	NOUN
fnp-5377	14	4	leads	lead	VERB
fnp-5377	14	5	to	to	ADP
fnp-5377	14	6	l-2	l-2	PROPN
fnp-5377	14	7	-	-	PUNCT
fnp-5377	14	8	hg	hg	NOUN
fnp-5377	14	9	accumulation	accumulation	NOUN
fnp-5377	14	10	with	with	ADP
fnp-5377	14	11	a	a	DET
fnp-5377	14	12	myelinotoxic	myelinotoxic	ADJ
fnp-5377	14	13	and	and	CCONJ
fnp-5377	14	14	oncogenic	oncogenic	ADJ
fnp-5377	14	15	effect	effect	NOUN
fnp-5377	14	16	on	on	ADP
fnp-5377	14	17	the	the	DET
fnp-5377	14	18	central	central	ADJ
fnp-5377	14	19	nervous	nervous	ADJ
fnp-5377	14	20	system	system	NOUN
fnp-5377	14	21	(	(	PUNCT
fnp-5377	14	22	cns	cns	NOUN
fnp-5377	14	23	)	)	PUNCT
fnp-5377	14	24	and	and	CCONJ
fnp-5377	14	25	l-2	l-2	PROPN
fnp-5377	14	26	-	-	PUNCT
fnp-5377	14	27	hg	hg	NOUN
fnp-5377	14	28	accumulation	accumulation	NOUN
fnp-5377	14	29	in	in	ADP
fnp-5377	14	30	urine	urine	NOUN
fnp-5377	14	31	,	,	PUNCT
fnp-5377	14	32	plasma	plasma	NOUN
fnp-5377	14	33	,	,	PUNCT
fnp-5377	14	34	and	and	CCONJ
fnp-5377	14	35	cerebrospinal	cerebrospinal	ADJ
fnp-5377	14	36	fluid.2	fluid.2	PROPN
fnp-5377	14	37	the	the	DET
fnp-5377	14	38	disease	disease	NOUN
fnp-5377	14	39	poses	pose	VERB
fnp-5377	14	40	a	a	DET
fnp-5377	14	41	relatively	relatively	ADV
fnp-5377	14	42	consistent	consistent	ADJ
fnp-5377	14	43	pattern	pattern	NOUN
fnp-5377	14	44	of	of	ADP
fnp-5377	14	45	presentation	presentation	NOUN
fnp-5377	14	46	,	,	PUNCT
fnp-5377	14	47	starting	start	VERB
fnp-5377	14	48	with	with	ADP
fnp-5377	14	49	delayed	delay	VERB
fnp-5377	14	50	mental	mental	ADJ
fnp-5377	14	51	and	and	CCONJ
fnp-5377	14	52	motor	motor	NOUN
fnp-5377	14	53	development	development	NOUN
fnp-5377	14	54	in	in	ADP
fnp-5377	14	55	the	the	DET
fnp-5377	14	56	first	first	ADJ
fnp-5377	14	57	years	year	NOUN
fnp-5377	14	58	of	of	ADP
fnp-5377	14	59	life	life	NOUN
fnp-5377	14	60	,	,	PUNCT
fnp-5377	14	61	epilepsy	epilepsy	NOUN
fnp-5377	14	62	in	in	ADP
fnp-5377	14	63	around	around	ADV
fnp-5377	14	64	60	60	NUM
fnp-5377	14	65	%	%	NOUN
fnp-5377	14	66	of	of	ADP
fnp-5377	14	67	the	the	DET
fnp-5377	14	68	cases	case	NOUN
fnp-5377	14	69	,	,	PUNCT
fnp-5377	14	70	continuing	continue	VERB
fnp-5377	14	71	with	with	ADP
fnp-5377	14	72	a	a	DET
fnp-5377	14	73	slowly	slowly	ADV
fnp-5377	14	74	progressive	progressive	ADJ
fnp-5377	14	75	course	course	NOUN
fnp-5377	14	76	eventually	eventually	ADV
fnp-5377	14	77	leading	lead	VERB
fnp-5377	14	78	to	to	ADP
fnp-5377	14	79	ataxia	ataxia	NOUN
fnp-5377	14	80	and	and	CCONJ
fnp-5377	14	81	moderate	moderate	ADJ
fnp-5377	14	82	to	to	ADP
fnp-5377	14	83	severe	severe	ADJ
fnp-5377	14	84	mental	mental	ADJ
fnp-5377	14	85	deterioration.2,3,4,5,6,7	deterioration.2,3,4,5,6,7	NOUN
fnp-5377	14	86	by	by	ADP
fnp-5377	14	87	imaging	imaging	PROPN
fnp-5377	14	88	,	,	PUNCT
fnp-5377	14	89	a	a	DET
fnp-5377	14	90	unique	unique	ADJ
fnp-5377	14	91	pattern	pattern	NOUN
fnp-5377	14	92	of	of	ADP
fnp-5377	14	93	abnormalities	abnormality	NOUN
fnp-5377	14	94	is	be	AUX
fnp-5377	14	95	seen	see	VERB
fnp-5377	14	96	,	,	PUNCT
fnp-5377	14	97	characterized	characterize	VERB
fnp-5377	14	98	by	by	ADP
fnp-5377	14	99	subcortical	subcortical	ADJ
fnp-5377	14	100	leukoencephalopathy	leukoencephalopathy	NOUN
fnp-5377	14	101	with	with	ADP
fnp-5377	14	102	relative	relative	ADJ
fnp-5377	14	103	sparing	sparing	NOUN
fnp-5377	14	104	of	of	ADP
fnp-5377	14	105	the	the	DET
fnp-5377	14	106	periventricular	periventricular	ADJ
fnp-5377	14	107	white	white	PROPN
fnp-5377	14	108	matter	matter	NOUN
fnp-5377	14	109	,	,	PUNCT
fnp-5377	14	110	corpus	corpus	NOUN
fnp-5377	14	111	callosum	callosum	NOUN
fnp-5377	14	112	,	,	PUNCT
fnp-5377	14	113	cerebellar	cerebellar	ADJ
fnp-5377	14	114	white	white	ADJ
fnp-5377	14	115	matter	matter	NOUN
fnp-5377	14	116	and	and	CCONJ
fnp-5377	14	117	the	the	DET
fnp-5377	14	118	brainstem	brainstem	NOUN
fnp-5377	14	119	tracts	tract	NOUN
fnp-5377	14	120	.	.	PUNCT
fnp-5377	15	1	additional	additional	ADJ
fnp-5377	15	2	signal	signal	NOUN
fnp-5377	15	3	alterations	alteration	NOUN
fnp-5377	15	4	in	in	ADP
fnp-5377	15	5	the	the	DET
fnp-5377	15	6	basal	basal	ADJ
fnp-5377	15	7	ganglia	ganglia	NOUN
fnp-5377	15	8	and	and	CCONJ
fnp-5377	15	9	dentate	dentate	ADJ
fnp-5377	15	10	nuclei	nucleus	NOUN
fnp-5377	15	11	are	be	AUX
fnp-5377	15	12	typical.2,8,9	typical.2,8,9	ADP
fnp-5377	15	13	a	a	DET
fnp-5377	15	14	minority	minority	NOUN
fnp-5377	15	15	of	of	ADP
fnp-5377	15	16	patients	patient	NOUN
fnp-5377	15	17	also	also	ADV
fnp-5377	15	18	develop	develop	VERB
fnp-5377	15	19	a	a	DET
fnp-5377	15	20	cns	cns	NOUN
fnp-5377	15	21	tumor	tumor	NOUN
fnp-5377	15	22	,	,	PUNCT
fnp-5377	15	23	usually	usually	ADV
fnp-5377	15	24	later	later	ADV
fnp-5377	15	25	in	in	ADP
fnp-5377	15	26	life.2	life.2	PROPN
fnp-5377	15	27	because	because	SCONJ
fnp-5377	15	28	of	of	ADP
fnp-5377	15	29	the	the	DET
fnp-5377	15	30	enhanced	enhanced	ADJ
fnp-5377	15	31	tumor	tumor	NOUN
fnp-5377	15	32	risk	risk	NOUN
fnp-5377	15	33	,	,	PUNCT
fnp-5377	15	34	regular	regular	ADJ
fnp-5377	15	35	imaging	imaging	NOUN
fnp-5377	15	36	for	for	ADP
fnp-5377	15	37	patients	patient	NOUN
fnp-5377	15	38	with	with	ADP
fnp-5377	15	39	l-2	l-2	PROPN
fnp-5377	15	40	-	-	PUNCT
fnp-5377	15	41	hga	hga	PROPN
fnp-5377	15	42	is	be	AUX
fnp-5377	15	43	part	part	NOUN
fnp-5377	15	44	of	of	ADP
fnp-5377	15	45	standard	standard	ADJ
fnp-5377	15	46	care	care	NOUN
fnp-5377	15	47	,	,	PUNCT
fnp-5377	15	48	typically	typically	ADV
fnp-5377	15	49	once	once	ADV
fnp-5377	15	50	per	per	ADP
fnp-5377	15	51	1	1	NUM
fnp-5377	15	52	or	or	CCONJ
fnp-5377	15	53	2	2	NUM
fnp-5377	15	54	years	year	NOUN
fnp-5377	15	55	.	.	PUNCT
fnp-5377	16	1	here	here	ADV
fnp-5377	16	2	we	we	PRON
fnp-5377	16	3	present	present	VERB
fnp-5377	16	4	a	a	DET
fnp-5377	16	5	teenager	teenager	NOUN
fnp-5377	16	6	with	with	ADP
fnp-5377	16	7	l-2	l-2	PROPN
fnp-5377	16	8	-	-	PUNCT
fnp-5377	16	9	hga	hga	PROPN
fnp-5377	16	10	who	who	PRON
fnp-5377	16	11	developed	develop	VERB
fnp-5377	16	12	a	a	DET
fnp-5377	16	13	glial	glial	ADJ
fnp-5377	16	14	neoplasm	neoplasm	NOUN
fnp-5377	16	15	in	in	ADP
fnp-5377	16	16	the	the	DET
fnp-5377	16	17	cerebral	cerebral	ADJ
fnp-5377	16	18	hemisphere	hemisphere	ADV
fnp-5377	16	19	.	.	PUNCT
fnp-5377	17	1	we	we	PRON
fnp-5377	17	2	hypothesized	hypothesize	VERB
fnp-5377	17	3	that	that	SCONJ
fnp-5377	17	4	the	the	DET
fnp-5377	17	5	oncogenesis	oncogenesis	NOUN
fnp-5377	17	6	of	of	ADP
fnp-5377	17	7	this	this	DET
fnp-5377	17	8	tumor	tumor	NOUN
fnp-5377	17	9	would	would	AUX
fnp-5377	17	10	be	be	AUX
fnp-5377	17	11	in	in	ADP
fnp-5377	17	12	line	line	NOUN
fnp-5377	17	13	with	with	ADP
fnp-5377	17	14	idh	idh	NOUN
fnp-5377	17	15	-	-	PUNCT
fnp-5377	17	16	mutant	mutant	NOUN
fnp-5377	17	17	astrocytomas	astrocytoma	NOUN
fnp-5377	17	18	where	where	SCONJ
fnp-5377	17	19	d-2	d-2	NOUN
fnp-5377	17	20	-	-	PUNCT
fnp-5377	17	21	hg	hg	NOUN
fnp-5377	17	22	(	(	PUNCT
fnp-5377	17	23	the	the	DET
fnp-5377	17	24	enantiomer	enantiomer	NOUN
fnp-5377	17	25	of	of	ADP
fnp-5377	17	26	l-2	l-2	PROPN
fnp-5377	17	27	-	-	PUNCT
fnp-5377	17	28	hg	hg	NOUN
fnp-5377	17	29	)	)	PUNCT
fnp-5377	17	30	is	be	AUX
fnp-5377	17	31	considered	consider	VERB
fnp-5377	17	32	the	the	DET
fnp-5377	17	33	oncometabolite	oncometabolite	NOUN
fnp-5377	17	34	leading	lead	VERB
fnp-5377	17	35	to	to	ADP
fnp-5377	17	36	the	the	DET
fnp-5377	17	37	glioma	glioma	NOUN
fnp-5377	17	38	cpg	cpg	PROPN
fnp-5377	17	39	island	island	NOUN
fnp-5377	17	40	methylated	methylate	VERB
fnp-5377	17	41	phenotype	phenotype	NOUN
fnp-5377	17	42	(	(	PUNCT
fnp-5377	17	43	g	g	NOUN
fnp-5377	17	44	-	-	PUNCT
fnp-5377	17	45	cimp).10,11	cimp).10,11	NOUN
fnp-5377	17	46	however	however	ADV
fnp-5377	17	47	,	,	PUNCT
fnp-5377	17	48	the	the	DET
fnp-5377	17	49	tumor	tumor	NOUN
fnp-5377	17	50	of	of	ADP
fnp-5377	17	51	the	the	DET
fnp-5377	17	52	l-2	l-2	PROPN
fnp-5377	17	53	-	-	PUNCT
fnp-5377	17	54	hga	hga	PROPN
fnp-5377	17	55	patient	patient	NOUN
fnp-5377	17	56	did	do	AUX
fnp-5377	17	57	not	not	PART
fnp-5377	17	58	show	show	VERB
fnp-5377	17	59	g	g	NOUN
fnp-5377	17	60	-	-	PUNCT
fnp-5377	17	61	cimp	cimp	NOUN
fnp-5377	17	62	and	and	CCONJ
fnp-5377	17	63	was	be	AUX
fnp-5377	17	64	challenging	challenge	VERB
fnp-5377	17	65	-	-	PUNCT
fnp-5377	17	66	to	to	PART
fnp-5377	17	67	-	-	PUNCT
fnp-5377	17	68	classify	classify	VERB
fnp-5377	17	69	,	,	PUNCT
fnp-5377	17	70	even	even	ADV
fnp-5377	17	71	using	use	VERB
fnp-5377	17	72	a	a	DET
fnp-5377	17	73	combination	combination	NOUN
fnp-5377	17	74	of	of	ADP
fnp-5377	17	75	state	state	NOUN
fnp-5377	17	76	of	of	ADP
fnp-5377	17	77	the	the	DET
fnp-5377	17	78	art	art	NOUN
fnp-5377	17	79	molecular	molecular	ADJ
fnp-5377	17	80	diagnostic	diagnostic	ADJ
fnp-5377	17	81	tools	tool	NOUN
fnp-5377	17	82	.	.	PUNCT
fnp-5377	18	1	additionally	additionally	ADV
fnp-5377	18	2	,	,	PUNCT
fnp-5377	18	3	we	we	PRON
fnp-5377	18	4	provide	provide	VERB
fnp-5377	18	5	an	an	DET
fnp-5377	18	6	overview	overview	NOUN
fnp-5377	18	7	of	of	ADP
fnp-5377	18	8	l-2	l-2	PROPN
fnp-5377	18	9	-	-	PUNCT
fnp-5377	18	10	hga	hga	PROPN
fnp-5377	18	11	-	-	PUNCT
fnp-5377	18	12	associated	associate	VERB
fnp-5377	18	13	cns	cns	PROPN
fnp-5377	18	14	tumors	tumor	NOUN
fnp-5377	18	15	reported	report	VERB
fnp-5377	18	16	in	in	ADP
fnp-5377	18	17	the	the	DET
fnp-5377	18	18	literature	literature	NOUN
fnp-5377	18	19	and	and	CCONJ
fnp-5377	18	20	discuss	discuss	VERB
fnp-5377	18	21	the	the	DET
fnp-5377	18	22	similarities	similarity	NOUN
fnp-5377	18	23	and	and	CCONJ
fnp-5377	18	24	differences	difference	NOUN
fnp-5377	18	25	with	with	ADP
fnp-5377	18	26	idh	idh	NOUN
fnp-5377	18	27	-	-	PUNCT
fnp-5377	18	28	mutant	mutant	NOUN
fnp-5377	18	29	gliomas	glioma	NOUN
fnp-5377	18	30	.	.	PUNCT
fnp-5377	19	1	case	case	NOUN
fnp-5377	19	2	a	a	DET
fnp-5377	19	3	16	16	NUM
fnp-5377	19	4	-	-	PUNCT
fnp-5377	19	5	year	year	NOUN
fnp-5377	19	6	-	-	PUNCT
fnp-5377	19	7	old	old	ADJ
fnp-5377	19	8	girl	girl	NOUN
fnp-5377	19	9	,	,	PUNCT
fnp-5377	19	10	the	the	DET
fnp-5377	19	11	sole	sole	ADJ
fnp-5377	19	12	child	child	NOUN
fnp-5377	19	13	of	of	ADP
fnp-5377	19	14	a	a	DET
fnp-5377	19	15	consanguineous	consanguineous	ADJ
fnp-5377	19	16	couple	couple	NOUN
fnp-5377	19	17	,	,	PUNCT
fnp-5377	19	18	experienced	experience	VERB
fnp-5377	19	19	a	a	DET
fnp-5377	19	20	normal	normal	ADJ
fnp-5377	19	21	early	early	ADJ
fnp-5377	19	22	development	development	NOUN
fnp-5377	19	23	and	and	CCONJ
fnp-5377	19	24	could	could	AUX
fnp-5377	19	25	walk	walk	VERB
fnp-5377	19	26	without	without	ADP
fnp-5377	19	27	support	support	NOUN
fnp-5377	19	28	at	at	ADP
fnp-5377	19	29	13	13	NUM
fnp-5377	19	30	months	month	NOUN
fnp-5377	19	31	.	.	PUNCT
fnp-5377	20	1	speech	speech	NOUN
fnp-5377	20	2	development	development	NOUN
fnp-5377	20	3	was	be	AUX
fnp-5377	20	4	delayed	delay	VERB
fnp-5377	20	5	,	,	PUNCT
fnp-5377	20	6	and	and	CCONJ
fnp-5377	20	7	she	she	PRON
fnp-5377	20	8	exhibited	exhibit	VERB
fnp-5377	20	9	mild	mild	ADJ
fnp-5377	20	10	motor	motor	NOUN
fnp-5377	20	11	coordination	coordination	NOUN
fnp-5377	20	12	issues	issue	NOUN
fnp-5377	20	13	.	.	PUNCT
fnp-5377	21	1	at	at	ADP
fnp-5377	21	2	5	5	NUM
fnp-5377	21	3	years	year	NOUN
fnp-5377	21	4	age	age	NOUN
fnp-5377	21	5	,	,	PUNCT
fnp-5377	21	6	an	an	DET
fnp-5377	21	7	mri	mri	NOUN
fnp-5377	21	8	revealed	reveal	VERB
fnp-5377	21	9	extensive	extensive	ADJ
fnp-5377	21	10	subcortical	subcortical	ADJ
fnp-5377	21	11	cerebral	cerebral	ADJ
fnp-5377	21	12	white	white	ADJ
fnp-5377	21	13	matter	matter	NOUN
fnp-5377	21	14	abnormalities	abnormality	NOUN
fnp-5377	21	15	and	and	CCONJ
fnp-5377	21	16	signal	signal	ADJ
fnp-5377	21	17	abnormalities	abnormality	NOUN
fnp-5377	21	18	in	in	ADP
fnp-5377	21	19	the	the	DET
fnp-5377	21	20	basal	basal	ADJ
fnp-5377	21	21	ganglia	ganglia	NOUN
fnp-5377	21	22	and	and	CCONJ
fnp-5377	21	23	dentate	dentate	ADJ
fnp-5377	21	24	nuclei	nucleus	NOUN
fnp-5377	21	25	,	,	PUNCT
fnp-5377	21	26	characteristic	characteristic	ADJ
fnp-5377	21	27	of	of	ADP
fnp-5377	21	28	l-2	l-2	PROPN
fnp-5377	21	29	-	-	PUNCT
fnp-5377	21	30	hga	hga	PROPN
fnp-5377	21	31	.	.	PUNCT
fnp-5377	22	1	the	the	DET
fnp-5377	22	2	diagnosis	diagnosis	NOUN
fnp-5377	22	3	was	be	AUX
fnp-5377	22	4	confirmed	confirm	VERB
fnp-5377	22	5	through	through	ADP
fnp-5377	22	6	elevated	elevated	ADJ
fnp-5377	22	7	urinary	urinary	ADJ
fnp-5377	22	8	excretion	excretion	NOUN
fnp-5377	22	9	of	of	ADP
fnp-5377	22	10	l-2	l-2	PROPN
fnp-5377	22	11	-	-	PUNCT
fnp-5377	22	12	hg	hg	PROPN
fnp-5377	22	13	and	and	CCONJ
fnp-5377	22	14	the	the	DET
fnp-5377	22	15	identification	identification	NOUN
fnp-5377	22	16	of	of	ADP
fnp-5377	22	17	a	a	DET
fnp-5377	22	18	homozygous	homozygous	ADJ
fnp-5377	22	19	variant	variant	NOUN
fnp-5377	22	20	in	in	ADP
fnp-5377	22	21	the	the	DET
fnp-5377	22	22	l2hgdh	l2hgdh	ADJ
fnp-5377	22	23	gene	gene	NOUN
fnp-5377	22	24	(	(	PUNCT
fnp-5377	22	25	l2hgdh(nm_024884.2	l2hgdh(nm_024884.2	PROPN
fnp-5377	22	26	):	):	PUNCT
fnp-5377	22	27	c.339	c.339	PROPN
fnp-5377	22	28	t	t	PROPN
fnp-5377	22	29	>	>	X
fnp-5377	22	30	a	a	DET
fnp-5377	22	31	p.(cys113*)).12	p.(cys113*)).12	NOUN
fnp-5377	22	32	the	the	DET
fnp-5377	22	33	parents	parent	NOUN
fnp-5377	22	34	were	be	AUX
fnp-5377	22	35	confirmed	confirm	VERB
fnp-5377	22	36	to	to	PART
fnp-5377	22	37	be	be	AUX
fnp-5377	22	38	heterozygous	heterozygous	ADJ
fnp-5377	22	39	for	for	ADP
fnp-5377	22	40	the	the	DET
fnp-5377	22	41	same	same	ADJ
fnp-5377	22	42	variant	variant	NOUN
fnp-5377	22	43	.	.	PUNCT
fnp-5377	23	1	over	over	ADP
fnp-5377	23	2	the	the	DET
fnp-5377	23	3	years	year	NOUN
fnp-5377	23	4	,	,	PUNCT
fnp-5377	23	5	the	the	DET
fnp-5377	23	6	patient	patient	NOUN
fnp-5377	23	7	developed	develop	VERB
fnp-5377	23	8	moderate	moderate	ADJ
fnp-5377	23	9	cognitive	cognitive	ADJ
fnp-5377	23	10	impairment	impairment	NOUN
fnp-5377	23	11	and	and	CCONJ
fnp-5377	23	12	mild	mild	ADJ
fnp-5377	23	13	cerebellar	cerebellar	ADJ
fnp-5377	23	14	ataxia	ataxia	NOUN
fnp-5377	23	15	.	.	PUNCT
fnp-5377	24	1	starting	start	VERB
fnp-5377	24	2	at	at	ADP
fnp-5377	24	3	the	the	DET
fnp-5377	24	4	age	age	NOUN
fnp-5377	24	5	of	of	ADP
fnp-5377	24	6	14	14	NUM
fnp-5377	24	7	,	,	PUNCT
fnp-5377	24	8	she	she	PRON
fnp-5377	24	9	experienced	experience	VERB
fnp-5377	24	10	occasional	occasional	ADJ
fnp-5377	24	11	epileptic	epileptic	ADJ
fnp-5377	24	12	seizures	seizure	NOUN
fnp-5377	24	13	,	,	PUNCT
fnp-5377	24	14	treated	treat	VERB
fnp-5377	24	15	with	with	ADP
fnp-5377	24	16	valproate	valproate	ADJ
fnp-5377	24	17	.	.	PUNCT
fnp-5377	25	1	mri	mri	NOUN
fnp-5377	25	2	at	at	ADP
fnp-5377	25	3	the	the	DET
fnp-5377	25	4	age	age	NOUN
fnp-5377	25	5	of	of	ADP
fnp-5377	25	6	14	14	NUM
fnp-5377	25	7	years	year	NOUN
fnp-5377	25	8	did	do	AUX
fnp-5377	25	9	not	not	PART
fnp-5377	25	10	show	show	VERB
fnp-5377	25	11	evidence	evidence	NOUN
fnp-5377	25	12	of	of	ADP
fnp-5377	25	13	tumor	tumor	NOUN
fnp-5377	25	14	development	development	NOUN
fnp-5377	25	15	.	.	PUNCT
fnp-5377	26	1	at	at	ADP
fnp-5377	26	2	age	age	NOUN
fnp-5377	26	3	16	16	NUM
fnp-5377	26	4	,	,	PUNCT
fnp-5377	26	5	a	a	DET
fnp-5377	26	6	new	new	ADJ
fnp-5377	26	7	mri	mri	NOUN
fnp-5377	26	8	,	,	PUNCT
fnp-5377	26	9	prompted	prompt	VERB
fnp-5377	26	10	by	by	ADP
fnp-5377	26	11	a	a	DET
fnp-5377	26	12	new	new	ADJ
fnp-5377	26	13	-	-	PUNCT
fnp-5377	26	14	onset	onset	NOUN
fnp-5377	26	15	subtle	subtle	ADJ
fnp-5377	26	16	left	left	ADJ
fnp-5377	26	17	-	-	PUNCT
fnp-5377	26	18	sided	sided	ADJ
fnp-5377	26	19	central	central	ADJ
fnp-5377	26	20	paresis	paresis	NOUN
fnp-5377	26	21	,	,	PUNCT
fnp-5377	26	22	revealed	reveal	VERB
fnp-5377	26	23	an	an	DET
fnp-5377	26	24	augmentation	augmentation	NOUN
fnp-5377	26	25	in	in	ADP
fnp-5377	26	26	t2	t2	NOUN
fnp-5377	26	27	hyperintensity	hyperintensity	NOUN
fnp-5377	26	28	and	and	CCONJ
fnp-5377	26	29	swelling	swell	VERB
fnp-5377	26	30	in	in	ADP
fnp-5377	26	31	most	most	ADJ
fnp-5377	26	32	of	of	ADP
fnp-5377	26	33	the	the	DET
fnp-5377	26	34	right	right	ADJ
fnp-5377	26	35	cerebral	cerebral	ADJ
fnp-5377	26	36	hemisphere	hemisphere	ADV
fnp-5377	26	37	.	.	PUNCT
fnp-5377	27	1	the	the	DET
fnp-5377	27	2	border	border	NOUN
fnp-5377	27	3	between	between	ADP
fnp-5377	27	4	cortex	cortex	NOUN
fnp-5377	27	5	and	and	CCONJ
fnp-5377	27	6	subcortical	subcortical	ADJ
fnp-5377	27	7	white	white	ADJ
fnp-5377	27	8	matter	matter	NOUN
fnp-5377	27	9	was	be	AUX
fnp-5377	27	10	blurred	blur	VERB
fnp-5377	27	11	,	,	PUNCT
fnp-5377	27	12	particularly	particularly	ADV
fnp-5377	27	13	medial	medial	ADJ
fnp-5377	27	14	in	in	ADP
fnp-5377	27	15	the	the	DET
fnp-5377	27	16	temporal	temporal	ADJ
fnp-5377	27	17	lobe	lobe	NOUN
fnp-5377	27	18	,	,	PUNCT
fnp-5377	27	19	where	where	SCONJ
fnp-5377	27	20	the	the	DET
fnp-5377	27	21	cortex	cortex	NOUN
fnp-5377	27	22	was	be	AUX
fnp-5377	27	23	thickened	thicken	VERB
fnp-5377	27	24	and	and	CCONJ
fnp-5377	27	25	had	have	VERB
fnp-5377	27	26	a	a	DET
fnp-5377	27	27	slightly	slightly	ADV
fnp-5377	27	28	increased	increase	VERB
fnp-5377	27	29	t2	t2	NOUN
fnp-5377	27	30	signal	signal	NOUN
fnp-5377	27	31	(	(	PUNCT
fnp-5377	27	32	figure	figure	NOUN
fnp-5377	27	33	1a	1a	NOUN
fnp-5377	27	34	)	)	PUNCT
fnp-5377	27	35	.	.	PUNCT
fnp-5377	28	1	a	a	DET
fnp-5377	28	2	similar	similar	ADJ
fnp-5377	28	3	tumorous	tumorous	ADJ
fnp-5377	28	4	area	area	NOUN
fnp-5377	28	5	was	be	AUX
fnp-5377	28	6	identified	identify	VERB
fnp-5377	28	7	in	in	ADP
fnp-5377	28	8	the	the	DET
fnp-5377	28	9	right	right	ADJ
fnp-5377	28	10	superior	superior	ADJ
fnp-5377	28	11	temporal	temporal	ADJ
fnp-5377	28	12	gyrus	gyrus	NOUN
fnp-5377	28	13	(	(	PUNCT
fnp-5377	28	14	figure	figure	NOUN
fnp-5377	28	15	1b	1b	NUM
fnp-5377	28	16	)	)	PUNCT
fnp-5377	28	17	.	.	PUNCT
fnp-5377	29	1	distinguishing	distinguish	VERB
fnp-5377	29	2	pre	pre	ADJ
fnp-5377	29	3	-	-	ADJ
fnp-5377	29	4	existing	exist	VERB
fnp-5377	29	5	abnormal	abnormal	ADJ
fnp-5377	29	6	white	white	ADJ
fnp-5377	29	7	matter	matter	NOUN
fnp-5377	29	8	related	relate	VERB
fnp-5377	29	9	to	to	ADP
fnp-5377	29	10	l-2	l-2	PROPN
fnp-5377	29	11	-	-	PUNCT
fnp-5377	29	12	hga	hga	PROPN
fnp-5377	29	13	from	from	ADP
fnp-5377	29	14	the	the	DET
fnp-5377	29	15	new	new	ADJ
fnp-5377	29	16	abnormalities	abnormality	NOUN
fnp-5377	29	17	within	within	ADP
fnp-5377	29	18	the	the	DET
fnp-5377	29	19	white	white	ADJ
fnp-5377	29	20	matter	matter	NOUN
fnp-5377	29	21	was	be	AUX
fnp-5377	29	22	challenging	challenging	ADJ
fnp-5377	29	23	.	.	PUNCT
fnp-5377	30	1	the	the	DET
fnp-5377	30	2	signal	signal	ADJ
fnp-5377	30	3	abnormalities	abnormality	NOUN
fnp-5377	30	4	extended	extend	VERB
fnp-5377	30	5	into	into	ADP
fnp-5377	30	6	the	the	DET
fnp-5377	30	7	right	right	ADJ
fnp-5377	30	8	thalamus	thalamus	NOUN
fnp-5377	30	9	,	,	PUNCT
fnp-5377	30	10	right	right	ADJ
fnp-5377	30	11	cerebral	cerebral	ADJ
fnp-5377	30	12	peduncle	peduncle	NOUN
fnp-5377	30	13	,	,	PUNCT
fnp-5377	30	14	pons	pon	NOUN
fnp-5377	30	15	,	,	PUNCT
fnp-5377	30	16	and	and	CCONJ
fnp-5377	30	17	were	be	AUX
fnp-5377	30	18	accompanied	accompany	VERB
fnp-5377	30	19	by	by	ADP
fnp-5377	30	20	subfalcine	subfalcine	NOUN
fnp-5377	30	21	herniation	herniation	NOUN
fnp-5377	30	22	and	and	CCONJ
fnp-5377	30	23	a	a	DET
fnp-5377	30	24	midline	midline	NOUN
fnp-5377	30	25	shift	shift	NOUN
fnp-5377	30	26	to	to	ADP
fnp-5377	30	27	the	the	DET
fnp-5377	30	28	left	left	NOUN
fnp-5377	30	29	(	(	PUNCT
fnp-5377	30	30	figure	figure	NOUN
fnp-5377	30	31	1a	1a	NOUN
fnp-5377	30	32	,	,	PUNCT
fnp-5377	30	33	b	b	NOUN
fnp-5377	30	34	)	)	PUNCT
fnp-5377	30	35	.	.	PUNCT
fnp-5377	31	1	post	post	ADJ
fnp-5377	31	2	-	-	ADJ
fnp-5377	31	3	contrast	contrast	ADJ
fnp-5377	31	4	scans	scan	NOUN
fnp-5377	31	5	did	do	AUX
fnp-5377	31	6	not	not	PART
fnp-5377	31	7	reveal	reveal	VERB
fnp-5377	31	8	abnormal	abnormal	ADJ
fnp-5377	31	9	enhancement	enhancement	NOUN
fnp-5377	31	10	.	.	PUNCT
fnp-5377	32	1	several	several	ADJ
fnp-5377	32	2	small	small	ADJ
fnp-5377	32	3	foci	focus	NOUN
fnp-5377	32	4	of	of	ADP
fnp-5377	32	5	diffusion	diffusion	NOUN
fnp-5377	32	6	restriction	restriction	NOUN
fnp-5377	32	7	were	be	AUX
fnp-5377	32	8	present	present	ADJ
fnp-5377	32	9	within	within	ADP
fnp-5377	32	10	the	the	DET
fnp-5377	32	11	tumor	tumor	NOUN
fnp-5377	32	12	.	.	PUNCT
fnp-5377	33	1	based	base	VERB
fnp-5377	33	2	on	on	ADP
fnp-5377	33	3	the	the	DET
fnp-5377	33	4	findings	finding	NOUN
fnp-5377	33	5	in	in	ADP
fnp-5377	33	6	serial	serial	ADJ
fnp-5377	33	7	mri	mri	NOUN
fnp-5377	33	8	examinations	examination	NOUN
fnp-5377	33	9	a	a	DET
fnp-5377	33	10	radiological	radiological	ADJ
fnp-5377	33	11	diagnosis	diagnosis	NOUN
fnp-5377	33	12	of	of	ADP
fnp-5377	33	13	a	a	DET
fnp-5377	33	14	rapidly	rapidly	ADV
fnp-5377	33	15	growing	grow	VERB
fnp-5377	33	16	,	,	PUNCT
fnp-5377	33	17	likely	likely	ADJ
fnp-5377	33	18	high	high	ADJ
fnp-5377	33	19	-	-	PUNCT
fnp-5377	33	20	grade	grade	NOUN
fnp-5377	33	21	glial	glial	ADJ
fnp-5377	33	22	tumor	tumor	NOUN
fnp-5377	33	23	was	be	AUX
fnp-5377	33	24	made	make	VERB
fnp-5377	33	25	.	.	PUNCT
fnp-5377	34	1	a	a	DET
fnp-5377	34	2	biopsy	biopsy	NOUN
fnp-5377	34	3	of	of	ADP
fnp-5377	34	4	the	the	DET
fnp-5377	34	5	tumor	tumor	NOUN
fnp-5377	34	6	was	be	AUX
fnp-5377	34	7	taken	take	VERB
fnp-5377	34	8	from	from	ADP
fnp-5377	34	9	the	the	DET
fnp-5377	34	10	right	right	ADJ
fnp-5377	34	11	temporal	temporal	ADJ
fnp-5377	34	12	lobe	lobe	NOUN
fnp-5377	34	13	near	near	ADP
fnp-5377	34	14	the	the	DET
fnp-5377	34	15	superior	superior	ADJ
fnp-5377	34	16	temporal	temporal	ADJ
fnp-5377	34	17	gyrus	gyrus	NOUN
fnp-5377	34	18	to	to	PART
fnp-5377	34	19	confirm	confirm	VERB
fnp-5377	34	20	its	its	PRON
fnp-5377	34	21	nature	nature	NOUN
fnp-5377	34	22	.	.	PUNCT
fnp-5377	35	1	figure	figure	NOUN
fnp-5377	35	2	1	1	NUM
fnp-5377	35	3	.	.	PUNCT
fnp-5377	35	4	preoperative	preoperative	ADJ
fnp-5377	35	5	mri	mri	PROPN
fnp-5377	35	6	.	.	PUNCT
fnp-5377	36	1	axial	axial	ADJ
fnp-5377	36	2	t2	t2	NOUN
fnp-5377	36	3	-	-	PUNCT
fnp-5377	36	4	weighted	weight	VERB
fnp-5377	36	5	mr	mr	PROPN
fnp-5377	36	6	images	image	NOUN
fnp-5377	36	7	with	with	ADP
fnp-5377	36	8	the	the	DET
fnp-5377	36	9	red	red	ADJ
fnp-5377	36	10	arrows	arrow	NOUN
fnp-5377	36	11	indicating	indicate	VERB
fnp-5377	36	12	a	a	DET
fnp-5377	36	13	space	space	NOUN
fnp-5377	36	14	occupying	occupy	VERB
fnp-5377	36	15	lesion	lesion	NOUN
fnp-5377	36	16	in	in	ADP
fnp-5377	36	17	the	the	DET
fnp-5377	36	18	medial	medial	ADJ
fnp-5377	36	19	part	part	NOUN
fnp-5377	36	20	of	of	ADP
fnp-5377	36	21	the	the	DET
fnp-5377	36	22	right	right	ADJ
fnp-5377	36	23	temporal	temporal	ADJ
fnp-5377	36	24	lobe	lobe	NOUN
fnp-5377	36	25	(	(	PUNCT
fnp-5377	36	26	a	a	NOUN
fnp-5377	36	27	)	)	PUNCT
fnp-5377	36	28	and	and	CCONJ
fnp-5377	36	29	in	in	ADP
fnp-5377	36	30	the	the	DET
fnp-5377	36	31	right	right	ADJ
fnp-5377	36	32	superior	superior	ADJ
fnp-5377	36	33	temporal	temporal	ADJ
fnp-5377	36	34	gyrus	gyrus	NOUN
fnp-5377	36	35	(	(	PUNCT
fnp-5377	36	36	b	b	NOUN
fnp-5377	36	37	,	,	PUNCT
fnp-5377	36	38	i.e.	i.e.	X
fnp-5377	36	39	the	the	DET
fnp-5377	36	40	location	location	NOUN
fnp-5377	36	41	of	of	ADP
fnp-5377	36	42	the	the	DET
fnp-5377	36	43	biopsy	biopsy	NOUN
fnp-5377	36	44	)	)	PUNCT
fnp-5377	36	45	,	,	PUNCT
fnp-5377	36	46	accompanied	accompany	VERB
fnp-5377	36	47	by	by	ADP
fnp-5377	36	48	midline	midline	NOUN
fnp-5377	36	49	shift	shift	NOUN
fnp-5377	36	50	and	and	CCONJ
fnp-5377	36	51	brain	brain	NOUN
fnp-5377	36	52	herniation	herniation	NOUN
fnp-5377	36	53	(	(	PUNCT
fnp-5377	36	54	transtentorial	transtentorial	ADJ
fnp-5377	36	55	in	in	ADP
fnp-5377	36	56	a	a	DET
fnp-5377	36	57	,	,	PUNCT
fnp-5377	36	58	subfalcine	subfalcine	NOUN
fnp-5377	36	59	in	in	ADP
fnp-5377	36	60	b	b	NOUN
fnp-5377	36	61	)	)	PUNCT
fnp-5377	36	62	.	.	PUNCT
fnp-5377	37	1	additionally	additionally	ADV
fnp-5377	37	2	,	,	PUNCT
fnp-5377	37	3	in	in	ADP
fnp-5377	37	4	both	both	DET
fnp-5377	37	5	hemispheres	hemisphere	NOUN
fnp-5377	37	6	t2	t2	NOUN
fnp-5377	37	7	hyperintensity	hyperintensity	NOUN
fnp-5377	37	8	of	of	ADP
fnp-5377	37	9	the	the	DET
fnp-5377	37	10	white	white	ADJ
fnp-5377	37	11	matter	matter	NOUN
fnp-5377	37	12	is	be	AUX
fnp-5377	37	13	present	present	ADJ
fnp-5377	37	14	,	,	PUNCT
fnp-5377	37	15	pathognomonic	pathognomonic	ADJ
fnp-5377	37	16	for	for	ADP
fnp-5377	37	17	l2	l2	NOUN
fnp-5377	37	18	-	-	PUNCT
fnp-5377	37	19	hga	hga	NOUN
fnp-5377	37	20	.	.	PUNCT
fnp-5377	38	1	histology	histology	PROPN
fnp-5377	38	2	histological	histological	ADJ
fnp-5377	38	3	analysis	analysis	NOUN
fnp-5377	38	4	revealed	reveal	VERB
fnp-5377	38	5	a	a	DET
fnp-5377	38	6	tumor	tumor	NOUN
fnp-5377	38	7	consisting	consist	VERB
fnp-5377	38	8	of	of	ADP
fnp-5377	38	9	small	small	ADJ
fnp-5377	38	10	,	,	PUNCT
fnp-5377	38	11	poorly	poorly	ADV
fnp-5377	38	12	differentiated	differentiate	VERB
fnp-5377	38	13	appearing	appearing	ADJ
fnp-5377	38	14	cells	cell	NOUN
fnp-5377	38	15	with	with	ADP
fnp-5377	38	16	diffuse	diffuse	ADJ
fnp-5377	38	17	infiltrative	infiltrative	ADJ
fnp-5377	38	18	growth	growth	NOUN
fnp-5377	38	19	in	in	ADP
fnp-5377	38	20	the	the	DET
fnp-5377	38	21	preexistent	preexistent	NOUN
fnp-5377	38	22	brain	brain	NOUN
fnp-5377	38	23	parenchyma	parenchyma	NOUN
fnp-5377	38	24	.	.	PUNCT
fnp-5377	39	1	the	the	DET
fnp-5377	39	2	tumor	tumor	NOUN
fnp-5377	39	3	cell	cell	NOUN
fnp-5377	39	4	nuclei	nucleus	NOUN
fnp-5377	39	5	were	be	AUX
fnp-5377	39	6	round	round	ADJ
fnp-5377	39	7	to	to	ADP
fnp-5377	39	8	ovoid	ovoid	ADJ
fnp-5377	39	9	,	,	PUNCT
fnp-5377	39	10	showed	show	VERB
fnp-5377	39	11	substantial	substantial	ADJ
fnp-5377	39	12	atypia	atypia	NOUN
fnp-5377	39	13	and	and	CCONJ
fnp-5377	39	14	fine	fine	ADV
fnp-5377	39	15	-	-	PUNCT
fnp-5377	39	16	grained	grain	VERB
fnp-5377	39	17	chromatin	chromatin	NOUN
fnp-5377	39	18	with	with	ADP
fnp-5377	39	19	small	small	ADJ
fnp-5377	39	20	nucleoli	nucleolus	NOUN
fnp-5377	39	21	.	.	PUNCT
fnp-5377	40	1	mitotic	mitotic	ADJ
fnp-5377	40	2	figures	figure	NOUN
fnp-5377	40	3	were	be	AUX
fnp-5377	40	4	frequent	frequent	ADJ
fnp-5377	40	5	.	.	PUNCT
fnp-5377	41	1	notably	notably	ADV
fnp-5377	41	2	,	,	PUNCT
fnp-5377	41	3	the	the	DET
fnp-5377	41	4	cells	cell	NOUN
fnp-5377	41	5	showed	show	VERB
fnp-5377	41	6	some	some	DET
fnp-5377	41	7	degree	degree	NOUN
fnp-5377	41	8	of	of	ADP
fnp-5377	41	9	clustering	cluster	VERB
fnp-5377	41	10	with	with	ADP
fnp-5377	41	11	small	small	ADJ
fnp-5377	41	12	areas	area	NOUN
fnp-5377	41	13	of	of	ADP
fnp-5377	41	14	pre	pre	ADJ
fnp-5377	41	15	-	-	ADJ
fnp-5377	41	16	existent	existent	ADJ
fnp-5377	41	17	neuropil	neuropil	NOUN
fnp-5377	41	18	in	in	ADP
fnp-5377	41	19	between	between	ADP
fnp-5377	41	20	clusters	cluster	NOUN
fnp-5377	41	21	,	,	PUNCT
fnp-5377	41	22	but	but	CCONJ
fnp-5377	41	23	lacked	lack	VERB
fnp-5377	41	24	true	true	ADJ
fnp-5377	41	25	rosettes	rosette	NOUN
fnp-5377	41	26	or	or	CCONJ
fnp-5377	41	27	evident	evident	ADJ
fnp-5377	41	28	perivascular	perivascular	ADJ
fnp-5377	41	29	pseudorosettes	pseudorosette	NOUN
fnp-5377	41	30	(	(	PUNCT
fnp-5377	41	31	figure	figure	NOUN
fnp-5377	41	32	2a	2a	NUM
fnp-5377	41	33	,	,	PUNCT
fnp-5377	41	34	b	b	NOUN
fnp-5377	41	35	)	)	PUNCT
fnp-5377	41	36	.	.	PUNCT
fnp-5377	42	1	florid	florid	ADJ
fnp-5377	42	2	microvascular	microvascular	ADJ
fnp-5377	42	3	proliferation	proliferation	NOUN
fnp-5377	42	4	and	and	CCONJ
fnp-5377	42	5	necrosis	necrosis	NOUN
fnp-5377	42	6	were	be	AUX
fnp-5377	42	7	absent	absent	ADJ
fnp-5377	42	8	.	.	PUNCT
fnp-5377	43	1	figure	figure	NOUN
fnp-5377	43	2	2	2	NUM
fnp-5377	43	3	.	.	NOUN
fnp-5377	43	4	histological	histological	ADJ
fnp-5377	43	5	and	and	CCONJ
fnp-5377	43	6	immunohistochemical	immunohistochemical	ADJ
fnp-5377	43	7	characteristics	characteristic	NOUN
fnp-5377	43	8	of	of	ADP
fnp-5377	43	9	the	the	DET
fnp-5377	43	10	tumor	tumor	NOUN
fnp-5377	43	11	.	.	PUNCT
fnp-5377	44	1	(	(	PUNCT
fnp-5377	44	2	a	a	DET
fnp-5377	44	3	,	,	PUNCT
fnp-5377	44	4	b	b	NOUN
fnp-5377	44	5	)	)	PUNCT
fnp-5377	44	6	low	low	ADJ
fnp-5377	44	7	and	and	CCONJ
fnp-5377	44	8	high	high	ADJ
fnp-5377	44	9	magnification	magnification	NOUN
fnp-5377	44	10	of	of	ADP
fnp-5377	44	11	the	the	DET
fnp-5377	44	12	diffuse	diffuse	PROPN
fnp-5377	44	13	infiltrative	infiltrative	ADJ
fnp-5377	44	14	high	high	ADJ
fnp-5377	44	15	-	-	PUNCT
fnp-5377	44	16	grade	grade	NOUN
fnp-5377	44	17	glioma	glioma	NOUN
fnp-5377	44	18	.	.	PUNCT
fnp-5377	45	1	(	(	PUNCT
fnp-5377	45	2	c	c	X
fnp-5377	45	3	-	-	SYM
fnp-5377	45	4	f	f	NOUN
fnp-5377	45	5	)	)	PUNCT
fnp-5377	45	6	immunoreactivity	immunoreactivity	NOUN
fnp-5377	45	7	for	for	ADP
fnp-5377	45	8	ki-67	ki-67	X
fnp-5377	45	9	(	(	PUNCT
fnp-5377	45	10	c	c	NOUN
fnp-5377	45	11	)	)	PUNCT
fnp-5377	45	12	,	,	PUNCT
fnp-5377	45	13	gfap	gfap	NOUN
fnp-5377	45	14	(	(	PUNCT
fnp-5377	45	15	d	d	NOUN
fnp-5377	45	16	)	)	PUNCT
fnp-5377	45	17	,	,	PUNCT
fnp-5377	45	18	map2	map2	NOUN
fnp-5377	45	19	(	(	PUNCT
fnp-5377	45	20	e	e	NOUN
fnp-5377	45	21	)	)	PUNCT
fnp-5377	45	22	and	and	CCONJ
fnp-5377	45	23	ema	ema	PROPN
fnp-5377	45	24	(	(	PUNCT
fnp-5377	45	25	f	f	NOUN
fnp-5377	45	26	)	)	PUNCT
fnp-5377	45	27	.	.	PUNCT
fnp-5377	46	1	scale	scale	NOUN
fnp-5377	46	2	bars	bar	NOUN
fnp-5377	46	3	:	:	PUNCT
fnp-5377	46	4	80	80	NUM
fnp-5377	46	5	um	um	INTJ
fnp-5377	46	6	(	(	PUNCT
fnp-5377	46	7	a	a	PRON
fnp-5377	46	8	,	,	PUNCT
fnp-5377	46	9	c	c	NOUN
fnp-5377	46	10	,	,	PUNCT
fnp-5377	46	11	d	d	PROPN
fnp-5377	46	12	)	)	PUNCT
fnp-5377	46	13	;	;	PUNCT
fnp-5377	46	14	50	50	NUM
fnp-5377	46	15	um	um	INTJ
fnp-5377	46	16	(	(	PUNCT
fnp-5377	46	17	b	b	NOUN
fnp-5377	46	18	,	,	PUNCT
fnp-5377	46	19	e	e	NOUN
fnp-5377	46	20	,	,	PUNCT
fnp-5377	46	21	f	f	NOUN
fnp-5377	46	22	)	)	PUNCT
fnp-5377	46	23	.	.	PUNCT
fnp-5377	47	1	immunohistochemically	immunohistochemically	ADV
fnp-5377	47	2	,	,	PUNCT
fnp-5377	47	3	the	the	DET
fnp-5377	47	4	tumor	tumor	NOUN
fnp-5377	47	5	cells	cell	NOUN
fnp-5377	47	6	were	be	AUX
fnp-5377	47	7	positive	positive	ADJ
fnp-5377	47	8	for	for	ADP
fnp-5377	47	9	vimentin	vimentin	NOUN
fnp-5377	47	10	,	,	PUNCT
fnp-5377	47	11	cd56	cd56	PROPN
fnp-5377	47	12	,	,	PUNCT
fnp-5377	47	13	and	and	CCONJ
fnp-5377	47	14	map2	map2	NOUN
fnp-5377	47	15	,	,	PUNCT
fnp-5377	47	16	and	and	CCONJ
fnp-5377	47	17	in	in	ADP
fnp-5377	47	18	some	some	DET
fnp-5377	47	19	areas	area	NOUN
fnp-5377	47	20	for	for	ADP
fnp-5377	47	21	synaptophysin	synaptophysin	NOUN
fnp-5377	47	22	and	and	CCONJ
fnp-5377	47	23	gfap	gfap	ADJ
fnp-5377	47	24	as	as	ADV
fnp-5377	47	25	well	well	ADV
fnp-5377	47	26	.	.	PUNCT
fnp-5377	48	1	dot	dot	NOUN
fnp-5377	48	2	-	-	PUNCT
fnp-5377	48	3	like	like	ADJ
fnp-5377	48	4	ema	ema	PROPN
fnp-5377	48	5	staining	stain	VERB
fnp-5377	48	6	was	be	AUX
fnp-5377	48	7	found	find	VERB
fnp-5377	48	8	in	in	ADP
fnp-5377	48	9	a	a	DET
fnp-5377	48	10	small	small	ADJ
fnp-5377	48	11	number	number	NOUN
fnp-5377	48	12	of	of	ADP
fnp-5377	48	13	tumor	tumor	NOUN
fnp-5377	48	14	cells	cell	NOUN
fnp-5377	48	15	.	.	PUNCT
fnp-5377	49	1	the	the	DET
fnp-5377	49	2	tumor	tumor	NOUN
fnp-5377	49	3	cells	cell	NOUN
fnp-5377	49	4	were	be	AUX
fnp-5377	49	5	negative	negative	ADJ
fnp-5377	49	6	in	in	ADP
fnp-5377	49	7	the	the	DET
fnp-5377	49	8	following	follow	VERB
fnp-5377	49	9	stainings	staining	NOUN
fnp-5377	49	10	:	:	PUNCT
fnp-5377	49	11	cam5.2	cam5.2	NUM
fnp-5377	49	12	,	,	PUNCT
fnp-5377	49	13	cd34	cd34	PROPN
fnp-5377	49	14	(	(	PUNCT
fnp-5377	49	15	with	with	ADP
fnp-5377	49	16	positive	positive	ADJ
fnp-5377	49	17	control	control	NOUN
fnp-5377	49	18	in	in	ADP
fnp-5377	49	19	the	the	DET
fnp-5377	49	20	vessels	vessel	NOUN
fnp-5377	49	21	)	)	PUNCT
fnp-5377	49	22	,	,	PUNCT
fnp-5377	49	23	neun	neun	INTJ
fnp-5377	49	24	(	(	PUNCT
fnp-5377	49	25	staining	stain	VERB
fnp-5377	49	26	only	only	ADV
fnp-5377	49	27	pre	pre	ADJ
fnp-5377	49	28	-	-	ADJ
fnp-5377	49	29	existing	existing	ADJ
fnp-5377	49	30	neurons	neuron	NOUN
fnp-5377	49	31	)	)	PUNCT
fnp-5377	49	32	,	,	PUNCT
fnp-5377	49	33	olig2	olig2	PROPN
fnp-5377	49	34	,	,	PUNCT
fnp-5377	49	35	idh1	idh1	PROPN
fnp-5377	49	36	r132h	r132h	PROPN
fnp-5377	49	37	and	and	CCONJ
fnp-5377	49	38	h3	h3	VERB
fnp-5377	49	39	p.k28	p.k28	PROPN
fnp-5377	49	40	m.	m.	NOUN
fnp-5377	49	41	furthermore	furthermore	ADV
fnp-5377	49	42	,	,	PUNCT
fnp-5377	49	43	in	in	ADP
fnp-5377	49	44	the	the	DET
fnp-5377	49	45	h3	h3	NOUN
fnp-5377	49	46	p.k28me3	p.k28me3	PROPN
fnp-5377	49	47	,	,	PUNCT
fnp-5377	49	48	atrx	atrx	ADJ
fnp-5377	49	49	,	,	PUNCT
fnp-5377	49	50	and	and	CCONJ
fnp-5377	49	51	ini-1	ini-1	ADV
fnp-5377	49	52	staining	stain	VERB
fnp-5377	49	53	the	the	DET
fnp-5377	49	54	nuclear	nuclear	ADJ
fnp-5377	49	55	expression	expression	NOUN
fnp-5377	49	56	was	be	AUX
fnp-5377	49	57	retained	retain	VERB
fnp-5377	49	58	.	.	PUNCT
fnp-5377	50	1	the	the	DET
fnp-5377	50	2	ki-67	ki-67	ADJ
fnp-5377	50	3	labelling	labelling	NOUN
fnp-5377	50	4	index	index	NOUN
fnp-5377	50	5	was	be	AUX
fnp-5377	50	6	variable	variable	ADJ
fnp-5377	50	7	but	but	CCONJ
fnp-5377	50	8	locally	locally	ADV
fnp-5377	50	9	>	>	X
fnp-5377	50	10	=	=	SYM
fnp-5377	50	11	30	30	NUM
fnp-5377	50	12	%	%	NOUN
fnp-5377	50	13	.	.	PUNCT
fnp-5377	51	1	(	(	PUNCT
fnp-5377	51	2	figure	figure	NOUN
fnp-5377	51	3	2c	2c	NUM
fnp-5377	51	4	-	-	PUNCT
fnp-5377	51	5	f	f	NOUN
fnp-5377	51	6	)	)	PUNCT
fnp-5377	51	7	.	.	PUNCT
fnp-5377	52	1	molecular	molecular	ADJ
fnp-5377	52	2	findings	finding	NOUN
fnp-5377	52	3	dna	dna	PROPN
fnp-5377	52	4	methylation	methylation	NOUN
fnp-5377	52	5	analysis	analysis	NOUN
fnp-5377	52	6	was	be	AUX
fnp-5377	52	7	performed	perform	VERB
fnp-5377	52	8	using	use	VERB
fnp-5377	52	9	the	the	DET
fnp-5377	52	10	infinium	infinium	NOUN
fnp-5377	52	11	methylationepic	methylationepic	NOUN
fnp-5377	52	12	beadchip	beadchip	NOUN
fnp-5377	52	13	(	(	PUNCT
fnp-5377	52	14	illumina	illumina	PROPN
fnp-5377	52	15	)	)	PUNCT
fnp-5377	52	16	,	,	PUNCT
fnp-5377	52	17	and	and	CCONJ
fnp-5377	52	18	explored	explore	VERB
fnp-5377	52	19	using	use	VERB
fnp-5377	52	20	versions	version	NOUN
fnp-5377	52	21	11b4	11b4	NUM
fnp-5377	52	22	,	,	PUNCT
fnp-5377	52	23	12.5	12.5	NUM
fnp-5377	52	24	and	and	CCONJ
fnp-5377	52	25	12.8	12.8	NUM
fnp-5377	52	26	of	of	ADP
fnp-5377	52	27	the	the	DET
fnp-5377	52	28	heidelberg	heidelberg	NOUN
fnp-5377	52	29	classifier	classifier	NOUN
fnp-5377	52	30	developed	develop	VERB
fnp-5377	52	31	by	by	ADP
fnp-5377	52	32	dkfz	dkfz	NOUN
fnp-5377	52	33	(	(	PUNCT
fnp-5377	52	34	https://www.molecularneuropathology.org/mnp/)8	https://www.molecularneuropathology.org/mnp/)8	X
fnp-5377	52	35	as	as	ADV
fnp-5377	52	36	well	well	ADV
fnp-5377	52	37	as	as	ADP
fnp-5377	52	38	the	the	DET
fnp-5377	52	39	bethesda	bethesda	NOUN
fnp-5377	52	40	classifier.13	classifier.13	VERB
fnp-5377	52	41	neither	neither	PRON
fnp-5377	52	42	of	of	ADP
fnp-5377	52	43	these	these	DET
fnp-5377	52	44	classifiers	classifier	NOUN
fnp-5377	52	45	were	be	AUX
fnp-5377	52	46	able	able	ADJ
fnp-5377	52	47	to	to	PART
fnp-5377	52	48	classify	classify	VERB
fnp-5377	52	49	the	the	DET
fnp-5377	52	50	tumor	tumor	NOUN
fnp-5377	52	51	with	with	ADP
fnp-5377	52	52	a	a	DET
fnp-5377	52	53	high	high	ADJ
fnp-5377	52	54	confidentiality	confidentiality	NOUN
fnp-5377	52	55	score	score	NOUN
fnp-5377	52	56	.	.	PUNCT
fnp-5377	53	1	the	the	DET
fnp-5377	53	2	best	good	ADJ
fnp-5377	53	3	classification	classification	NOUN
fnp-5377	53	4	possible	possible	ADJ
fnp-5377	53	5	was	be	AUX
fnp-5377	53	6	obtained	obtain	VERB
fnp-5377	53	7	with	with	ADP
fnp-5377	53	8	dkfz	dkfz	ADJ
fnp-5377	53	9	v12.8	v12.8	NOUN
fnp-5377	53	10	which	which	PRON
fnp-5377	53	11	classified	classify	VERB
fnp-5377	53	12	the	the	DET
fnp-5377	53	13	tumor	tumor	NOUN
fnp-5377	53	14	as	as	ADP
fnp-5377	53	15	pediatric	pediatric	ADJ
fnp-5377	53	16	-	-	PUNCT
fnp-5377	53	17	type	type	NOUN
fnp-5377	53	18	diffuse	diffuse	NOUN
fnp-5377	53	19	high	high	ADJ
fnp-5377	53	20	-	-	PUNCT
fnp-5377	53	21	grade	grade	NOUN
fnp-5377	53	22	glioma	glioma	NOUN
fnp-5377	53	23	with	with	ADP
fnp-5377	53	24	a	a	DET
fnp-5377	53	25	highest	high	ADJ
fnp-5377	53	26	score	score	NOUN
fnp-5377	53	27	of	of	ADP
fnp-5377	53	28	0.83	0.83	NUM
fnp-5377	53	29	,	,	PUNCT
fnp-5377	53	30	diffuse	diffuse	ADJ
fnp-5377	53	31	paediatric	paediatric	ADJ
fnp-5377	53	32	type	type	NOUN
fnp-5377	53	33	high	high	ADJ
fnp-5377	53	34	grade	grade	NOUN
fnp-5377	53	35	glioma	glioma	NOUN
fnp-5377	53	36	,	,	PUNCT
fnp-5377	53	37	mycn	mycn	NOUN
fnp-5377	53	38	subtype	subtype	NOUN
fnp-5377	53	39	(	(	PUNCT
fnp-5377	53	40	calibrated	calibrate	VERB
fnp-5377	53	41	score	score	NOUN
fnp-5377	53	42	0.52	0.52	NUM
fnp-5377	53	43	)	)	PUNCT
fnp-5377	53	44	.	.	PUNCT
fnp-5377	54	1	the	the	DET
fnp-5377	54	2	bethesda	bethesda	NOUN
fnp-5377	54	3	classifier	classifier	NOUN
fnp-5377	54	4	and	and	CCONJ
fnp-5377	54	5	umap	umap	ADJ
fnp-5377	54	6	(	(	PUNCT
fnp-5377	54	7	uniform	uniform	ADJ
fnp-5377	54	8	manifold	manifold	ADJ
fnp-5377	54	9	approximation	approximation	NOUN
fnp-5377	54	10	and	and	CCONJ
fnp-5377	54	11	projection	projection	NOUN
fnp-5377	54	12	)	)	PUNCT
fnp-5377	54	13	suggested	suggest	VERB
fnp-5377	54	14	idh	idh	NOUN
fnp-5377	54	15	-	-	PUNCT
fnp-5377	54	16	mutant	mutant	NOUN
fnp-5377	54	17	glioma	glioma	NOUN
fnp-5377	54	18	with	with	ADP
fnp-5377	54	19	a	a	DET
fnp-5377	54	20	score	score	NOUN
fnp-5377	54	21	of	of	ADP
fnp-5377	54	22	0.54	0.54	NUM
fnp-5377	54	23	.	.	PUNCT
fnp-5377	55	1	based	base	VERB
fnp-5377	55	2	on	on	ADP
fnp-5377	55	3	dna	dna	PROPN
fnp-5377	55	4	methylation	methylation	NOUN
fnp-5377	55	5	-	-	PUNCT
fnp-5377	55	6	based	base	VERB
fnp-5377	55	7	t	t	NOUN
fnp-5377	55	8	-	-	PUNCT
fnp-5377	55	9	distributed	distribute	VERB
fnp-5377	55	10	stochastic	stochastic	ADJ
fnp-5377	55	11	neighbor	neighbor	NOUN
fnp-5377	55	12	embedding	embed	VERB
fnp-5377	55	13	(	(	PUNCT
fnp-5377	55	14	t	t	PROPN
fnp-5377	55	15	-	-	PUNCT
fnp-5377	55	16	sne	sne	NOUN
fnp-5377	55	17	)	)	PUNCT
fnp-5377	55	18	clustering	cluster	VERB
fnp-5377	55	19	analyses	analysis	NOUN
fnp-5377	55	20	,	,	PUNCT
fnp-5377	55	21	this	this	DET
fnp-5377	55	22	tumor	tumor	NOUN
fnp-5377	55	23	clustered	cluster	VERB
fnp-5377	55	24	most	most	ADV
fnp-5377	55	25	close	close	ADJ
fnp-5377	55	26	to	to	ADP
fnp-5377	55	27	pediatric	pediatric	ADJ
fnp-5377	55	28	-	-	PUNCT
fnp-5377	55	29	type	type	NOUN
fnp-5377	55	30	diffuse	diffuse	NOUN
fnp-5377	55	31	high	high	ADJ
fnp-5377	55	32	-	-	PUNCT
fnp-5377	55	33	grade	grade	NOUN
fnp-5377	55	34	glioma	glioma	NOUN
fnp-5377	55	35	,	,	PUNCT
fnp-5377	55	36	mycn	mycn	NOUN
fnp-5377	55	37	-	-	PUNCT
fnp-5377	55	38	activated	activate	VERB
fnp-5377	55	39	subtype	subtype	NOUN
fnp-5377	55	40	(	(	PUNCT
fnp-5377	55	41	figure	figure	NOUN
fnp-5377	55	42	3a	3a	NUM
fnp-5377	55	43	)	)	PUNCT
fnp-5377	55	44	.	.	PUNCT
fnp-5377	56	1	figure	figure	VERB
fnp-5377	56	2	3	3	NUM
fnp-5377	56	3	.	.	PUNCT
fnp-5377	56	4	dna	dna	PROPN
fnp-5377	56	5	methylation	methylation	NOUN
fnp-5377	56	6	analysis	analysis	NOUN
fnp-5377	56	7	of	of	ADP
fnp-5377	56	8	the	the	DET
fnp-5377	56	9	tumor	tumor	NOUN
fnp-5377	56	10	.	.	PUNCT
fnp-5377	57	1	(	(	PUNCT
fnp-5377	57	2	a	a	X
fnp-5377	57	3	)	)	PUNCT
fnp-5377	57	4	dna	dna	PROPN
fnp-5377	57	5	methylation	methylation	NOUN
fnp-5377	57	6	-	-	PUNCT
fnp-5377	57	7	based	base	VERB
fnp-5377	57	8	t	t	NOUN
fnp-5377	57	9	-	-	PUNCT
fnp-5377	57	10	distributed	distribute	VERB
fnp-5377	57	11	stochastic	stochastic	ADJ
fnp-5377	57	12	neighbor	neighbor	NOUN
fnp-5377	57	13	embedding	embed	VERB
fnp-5377	57	14	(	(	PUNCT
fnp-5377	57	15	tsne	tsne	NOUN
fnp-5377	57	16	)	)	PUNCT
fnp-5377	57	17	of	of	ADP
fnp-5377	57	18	the	the	DET
fnp-5377	57	19	tumor	tumor	NOUN
fnp-5377	57	20	of	of	ADP
fnp-5377	57	21	our	our	PRON
fnp-5377	57	22	patient	patient	NOUN
fnp-5377	57	23	with	with	ADP
fnp-5377	57	24	l-2	l-2	PROPN
fnp-5377	57	25	-	-	PUNCT
fnp-5377	57	26	hga	hga	PROPN
fnp-5377	57	27	(	(	PUNCT
fnp-5377	57	28	marked	mark	VERB
fnp-5377	57	29	as	as	ADP
fnp-5377	57	30	index	index	NOUN
fnp-5377	57	31	,	,	PUNCT
fnp-5377	57	32	see	see	VERB
fnp-5377	57	33	arrow	arrow	NOUN
fnp-5377	57	34	)	)	PUNCT
fnp-5377	57	35	compared	compare	VERB
fnp-5377	57	36	to	to	ADP
fnp-5377	57	37	selected	select	VERB
fnp-5377	57	38	reference	reference	NOUN
fnp-5377	57	39	samples	sample	NOUN
fnp-5377	57	40	from	from	ADP
fnp-5377	57	41	the	the	DET
fnp-5377	57	42	heidelberg	heidelberg	NOUN
fnp-5377	57	43	database	database	NOUN
fnp-5377	57	44	(	(	PUNCT
fnp-5377	57	45	see	see	VERB
fnp-5377	57	46	supplemental	supplemental	ADJ
fnp-5377	57	47	data	datum	NOUN
fnp-5377	57	48	for	for	ADP
fnp-5377	57	49	abbreviations	abbreviation	NOUN
fnp-5377	57	50	)	)	PUNCT
fnp-5377	57	51	.	.	PUNCT
fnp-5377	58	1	the	the	DET
fnp-5377	58	2	tsne	tsne	NOUN
fnp-5377	58	3	was	be	AUX
fnp-5377	58	4	run	run	VERB
fnp-5377	58	5	with	with	ADP
fnp-5377	58	6	following	follow	VERB
fnp-5377	58	7	settings	setting	NOUN
fnp-5377	58	8	:	:	PUNCT
fnp-5377	58	9	cpgs	cpgs	PROPN
fnp-5377	58	10	analysed	analyse	VERB
fnp-5377	58	11	=	=	NOUN
fnp-5377	58	12	10.000	10.000	NUM
fnp-5377	58	13	,	,	PUNCT
fnp-5377	58	14	iterations	iteration	NOUN
fnp-5377	58	15	=	=	SYM
fnp-5377	58	16	3.000	3.000	NUM
fnp-5377	58	17	,	,	PUNCT
fnp-5377	58	18	perplexity	perplexity	NOUN
fnp-5377	58	19	=	=	SYM
fnp-5377	58	20	5	5	NUM
fnp-5377	58	21	,	,	PUNCT
fnp-5377	58	22	theta	theta	NOUN
fnp-5377	58	23	=	=	SYM
fnp-5377	58	24	0	0	NUM
fnp-5377	58	25	,	,	PUNCT
fnp-5377	58	26	dims	dim	VERB
fnp-5377	58	27	=	=	SYM
fnp-5377	58	28	2	2	X
fnp-5377	58	29	.	.	PUNCT
fnp-5377	59	1	our	our	PRON
fnp-5377	59	2	case	case	NOUN
fnp-5377	59	3	was	be	AUX
fnp-5377	59	4	in	in	ADP
fnp-5377	59	5	close	close	ADJ
fnp-5377	59	6	proximity	proximity	NOUN
fnp-5377	59	7	to	to	ADP
fnp-5377	59	8	mycn	mycn	VERB
fnp-5377	59	9	-	-	PUNCT
fnp-5377	59	10	activated	activate	VERB
fnp-5377	59	11	pediatric	pediatric	ADJ
fnp-5377	59	12	high	high	ADJ
fnp-5377	59	13	-	-	PUNCT
fnp-5377	59	14	grade	grade	NOUN
fnp-5377	59	15	gliomas	glioma	NOUN
fnp-5377	59	16	.	.	PUNCT
fnp-5377	60	1	samples	sample	NOUN
fnp-5377	60	2	are	be	AUX
fnp-5377	60	3	colored	color	VERB
fnp-5377	60	4	according	accord	VERB
fnp-5377	60	5	to	to	ADP
fnp-5377	60	6	their	their	PRON
fnp-5377	60	7	methylation	methylation	NOUN
fnp-5377	60	8	class	class	NOUN
fnp-5377	60	9	.	.	PUNCT
fnp-5377	61	1	(	(	PUNCT
fnp-5377	61	2	b	b	X
fnp-5377	61	3	)	)	PUNCT
fnp-5377	61	4	copy	copy	NOUN
fnp-5377	61	5	number	number	NOUN
fnp-5377	61	6	plot	plot	NOUN
fnp-5377	61	7	showing	show	VERB
fnp-5377	61	8	a	a	DET
fnp-5377	61	9	rather	rather	ADV
fnp-5377	61	10	complex	complex	ADJ
fnp-5377	61	11	profile	profile	NOUN
fnp-5377	61	12	with	with	ADP
fnp-5377	61	13	multiple	multiple	ADJ
fnp-5377	61	14	chromosomal	chromosomal	ADJ
fnp-5377	61	15	gains	gain	NOUN
fnp-5377	61	16	and	and	CCONJ
fnp-5377	61	17	losses	loss	NOUN
fnp-5377	61	18	.	.	PUNCT
fnp-5377	62	1	(	(	PUNCT
fnp-5377	62	2	c	c	X
fnp-5377	62	3	,	,	PUNCT
fnp-5377	62	4	d	d	NOUN
fnp-5377	62	5	)	)	PUNCT
fnp-5377	62	6	methylation	methylation	NOUN
fnp-5377	62	7	status	status	NOUN
fnp-5377	62	8	in	in	ADP
fnp-5377	62	9	comparison	comparison	NOUN
fnp-5377	62	10	to	to	ADP
fnp-5377	62	11	idh	idh	NOUN
fnp-5377	62	12	-	-	PUNCT
fnp-5377	62	13	mutant	mutant	NOUN
fnp-5377	62	14	gliomas	glioma	NOUN
fnp-5377	62	15	.	.	PUNCT
fnp-5377	63	1	unsupervised	unsupervised	ADJ
fnp-5377	63	2	analysis	analysis	NOUN
fnp-5377	63	3	using	use	VERB
fnp-5377	63	4	the	the	DET
fnp-5377	63	5	1000	1000	NUM
fnp-5377	63	6	most	most	ADV
fnp-5377	63	7	variable	variable	ADJ
fnp-5377	63	8	probes	probe	NOUN
fnp-5377	63	9	of	of	ADP
fnp-5377	63	10	a	a	DET
fnp-5377	63	11	cohort	cohort	NOUN
fnp-5377	63	12	of	of	ADP
fnp-5377	63	13	435	435	NUM
fnp-5377	63	14	idh	idh	NOUN
fnp-5377	63	15	-	-	PUNCT
fnp-5377	63	16	mutant	mutant	NOUN
fnp-5377	63	17	and	and	CCONJ
fnp-5377	63	18	215	215	NUM
fnp-5377	63	19	idh	idh	NOUN
fnp-5377	63	20	-	-	PUNCT
fnp-5377	63	21	wildtype	wildtype	NOUN
fnp-5377	63	22	gliomas15	gliomas15	NOUN
fnp-5377	63	23	revealed	reveal	VERB
fnp-5377	63	24	that	that	SCONJ
fnp-5377	63	25	the	the	DET
fnp-5377	63	26	tumor	tumor	NOUN
fnp-5377	63	27	of	of	ADP
fnp-5377	63	28	our	our	PRON
fnp-5377	63	29	patient	patient	NOUN
fnp-5377	63	30	clustered	cluster	VERB
fnp-5377	63	31	amongst	amongst	ADP
fnp-5377	63	32	the	the	DET
fnp-5377	63	33	idh	idh	NOUN
fnp-5377	63	34	-	-	PUNCT
fnp-5377	63	35	wildtype	wildtype	NOUN
fnp-5377	63	36	tumors	tumor	NOUN
fnp-5377	63	37	(	(	PUNCT
fnp-5377	63	38	figure	figure	VERB
fnp-5377	63	39	3c	3c	NUM
fnp-5377	63	40	,	,	PUNCT
fnp-5377	63	41	color	color	NOUN
fnp-5377	63	42	-	-	PUNCT
fnp-5377	63	43	coding	coding	NOUN
fnp-5377	63	44	of	of	ADP
fnp-5377	63	45	the	the	DET
fnp-5377	63	46	samples	sample	NOUN
fnp-5377	63	47	:	:	PUNCT
fnp-5377	63	48	idh	idh	NOUN
fnp-5377	63	49	-	-	PUNCT
fnp-5377	63	50	mutant	mutant	NOUN
fnp-5377	63	51	,	,	PUNCT
fnp-5377	63	52	idh	idh	NOUN
fnp-5377	63	53	-	-	PUNCT
fnp-5377	63	54	wildtype	wildtype	NOUN
fnp-5377	63	55	and	and	CCONJ
fnp-5377	63	56	unknown	unknown	ADJ
fnp-5377	63	57	samples	sample	NOUN
fnp-5377	63	58	are	be	AUX
fnp-5377	63	59	indicated	indicate	VERB
fnp-5377	63	60	respectively	respectively	ADV
fnp-5377	63	61	in	in	ADP
fnp-5377	63	62	green	green	ADJ
fnp-5377	63	63	,	,	PUNCT
fnp-5377	63	64	red	red	ADJ
fnp-5377	63	65	and	and	CCONJ
fnp-5377	63	66	grey	grey	NOUN
fnp-5377	63	67	.	.	PUNCT
fnp-5377	64	1	the	the	DET
fnp-5377	64	2	index	index	NOUN
fnp-5377	64	3	case	case	NOUN
fnp-5377	64	4	is	be	AUX
fnp-5377	64	5	indicated	indicate	VERB
fnp-5377	64	6	in	in	ADP
fnp-5377	64	7	blue	blue	ADJ
fnp-5377	64	8	and	and	CCONJ
fnp-5377	64	9	by	by	ADP
fnp-5377	64	10	the	the	DET
fnp-5377	64	11	red	red	ADJ
fnp-5377	64	12	rectangle	rectangle	NOUN
fnp-5377	64	13	)	)	PUNCT
fnp-5377	64	14	.	.	PUNCT
fnp-5377	65	1	(	(	PUNCT
fnp-5377	65	2	figure	figure	NOUN
fnp-5377	65	3	3d	3d	NUM
fnp-5377	65	4	,	,	PUNCT
fnp-5377	65	5	mean	mean	ADJ
fnp-5377	65	6	methylation	methylation	NOUN
fnp-5377	65	7	beta	beta	NOUN
fnp-5377	65	8	value	value	NOUN
fnp-5377	65	9	of	of	ADP
fnp-5377	65	10	the	the	DET
fnp-5377	65	11	1000	1000	NUM
fnp-5377	65	12	most	most	ADV
fnp-5377	65	13	variable	variable	ADJ
fnp-5377	65	14	probes	probe	NOUN
fnp-5377	65	15	shown	show	VERB
fnp-5377	65	16	in	in	ADP
fnp-5377	65	17	c.	c.	PROPN
fnp-5377	65	18	the	the	DET
fnp-5377	65	19	idh	idh	NOUN
fnp-5377	65	20	-	-	PUNCT
fnp-5377	65	21	wildtype	wildtype	NOUN
fnp-5377	65	22	cases	case	NOUN
fnp-5377	65	23	are	be	AUX
fnp-5377	65	24	colored	color	VERB
fnp-5377	65	25	in	in	ADP
fnp-5377	65	26	red	red	ADJ
fnp-5377	65	27	,	,	PUNCT
fnp-5377	65	28	the	the	DET
fnp-5377	65	29	idh	idh	NOUN
fnp-5377	65	30	-	-	PUNCT
fnp-5377	65	31	mutant	mutant	NOUN
fnp-5377	65	32	cases	case	NOUN
fnp-5377	65	33	in	in	ADP
fnp-5377	65	34	green	green	ADJ
fnp-5377	65	35	and	and	CCONJ
fnp-5377	65	36	the	the	DET
fnp-5377	65	37	index	index	NOUN
fnp-5377	65	38	sample	sample	NOUN
fnp-5377	65	39	is	be	AUX
fnp-5377	65	40	highlighted	highlight	VERB
fnp-5377	65	41	with	with	ADP
fnp-5377	65	42	an	an	DET
fnp-5377	65	43	orange	orange	ADJ
fnp-5377	65	44	triangle	triangle	NOUN
fnp-5377	65	45	.	.	PUNCT
fnp-5377	65	46	)	)	PUNCT
fnp-5377	66	1	the	the	DET
fnp-5377	66	2	copy	copy	NOUN
fnp-5377	66	3	number	number	NOUN
fnp-5377	66	4	variation	variation	NOUN
fnp-5377	66	5	(	(	PUNCT
fnp-5377	66	6	cnv	cnv	NOUN
fnp-5377	66	7	)	)	PUNCT
fnp-5377	66	8	plot	plot	NOUN
fnp-5377	66	9	obtained	obtain	VERB
fnp-5377	66	10	by	by	ADP
fnp-5377	66	11	the	the	DET
fnp-5377	66	12	conumee	conumee	PROPN
fnp-5377	66	13	package	package	NOUN
fnp-5377	66	14	embedded	embed	VERB
fnp-5377	66	15	in	in	ADP
fnp-5377	66	16	the	the	DET
fnp-5377	66	17	methylome	methylome	ADJ
fnp-5377	66	18	profiling	profiling	NOUN
fnp-5377	66	19	analysis	analysis	NOUN
fnp-5377	66	20	and	and	CCONJ
fnp-5377	66	21	whole	whole	ADJ
fnp-5377	66	22	exome	exome	NOUN
fnp-5377	66	23	sequencing	sequence	VERB
fnp-5377	66	24	(	(	PUNCT
fnp-5377	66	25	wes	wes	PROPN
fnp-5377	66	26	)	)	PUNCT
fnp-5377	66	27	revealed	reveal	VERB
fnp-5377	66	28	a	a	DET
fnp-5377	66	29	complex	complex	ADJ
fnp-5377	66	30	cnv	cnv	NOUN
fnp-5377	66	31	profile	profile	NOUN
fnp-5377	66	32	with	with	ADP
fnp-5377	66	33	multiple	multiple	ADJ
fnp-5377	66	34	gains	gain	NOUN
fnp-5377	66	35	and	and	CCONJ
fnp-5377	66	36	losses	loss	NOUN
fnp-5377	66	37	,	,	PUNCT
fnp-5377	66	38	including	include	VERB
fnp-5377	66	39	partial	partial	ADJ
fnp-5377	66	40	loss	loss	NOUN
fnp-5377	66	41	of	of	ADP
fnp-5377	66	42	chromosome	chromosome	NOUN
fnp-5377	66	43	10q	10q	NOUN
fnp-5377	66	44	.	.	PUNCT
fnp-5377	67	1	there	there	PRON
fnp-5377	67	2	was	be	VERB
fnp-5377	67	3	no	no	DET
fnp-5377	67	4	high	high	ADJ
fnp-5377	67	5	-	-	PUNCT
fnp-5377	67	6	level	level	NOUN
fnp-5377	67	7	amplification	amplification	NOUN
fnp-5377	67	8	of	of	ADP
fnp-5377	67	9	egfr	egfr	NOUN
fnp-5377	67	10	or	or	CCONJ
fnp-5377	67	11	mycn	mycn	NOUN
fnp-5377	67	12	,	,	PUNCT
fnp-5377	67	13	no	no	DET
fnp-5377	67	14	chromosome	chromosome	NOUN
fnp-5377	67	15	7	7	NUM
fnp-5377	67	16	gain	gain	NOUN
fnp-5377	67	17	,	,	PUNCT
fnp-5377	67	18	no	no	DET
fnp-5377	67	19	homozygous	homozygous	ADJ
fnp-5377	67	20	deletion	deletion	NOUN
fnp-5377	67	21	of	of	ADP
fnp-5377	67	22	cdkn2a	cdkn2a	PROPN
fnp-5377	67	23	/	/	SYM
fnp-5377	67	24	b	b	PROPN
fnp-5377	67	25	and	and	CCONJ
fnp-5377	67	26	no	no	DET
fnp-5377	67	27	chromosome	chromosome	NOUN
fnp-5377	67	28	1p/19q	1p/19q	NOUN
fnp-5377	67	29	codeletion	codeletion	NOUN
fnp-5377	67	30	(	(	PUNCT
fnp-5377	67	31	figure	figure	NOUN
fnp-5377	67	32	3b	3b	NUM
fnp-5377	67	33	)	)	PUNCT
fnp-5377	67	34	.	.	PUNCT
fnp-5377	68	1	the	the	DET
fnp-5377	68	2	promoter	promoter	NOUN
fnp-5377	68	3	of	of	ADP
fnp-5377	68	4	the	the	DET
fnp-5377	68	5	o6	o6	NOUN
fnp-5377	68	6	-	-	PUNCT
fnp-5377	68	7	methylguanine	methylguanine	NOUN
fnp-5377	68	8	-	-	PUNCT
fnp-5377	68	9	dna	dna	NOUN
fnp-5377	68	10	methyltransferase	methyltransferase	NOUN
fnp-5377	68	11	(	(	PUNCT
fnp-5377	68	12	mgmt	mgmt	NOUN
fnp-5377	68	13	)	)	PUNCT
fnp-5377	68	14	gene	gene	NOUN
fnp-5377	68	15	was	be	AUX
fnp-5377	68	16	found	find	VERB
fnp-5377	68	17	to	to	PART
fnp-5377	68	18	be	be	AUX
fnp-5377	68	19	methylated	methylate	VERB
fnp-5377	68	20	.	.	PUNCT
fnp-5377	69	1	wes	wes	PROPN
fnp-5377	69	2	identified	identify	VERB
fnp-5377	69	3	somatic	somatic	ADJ
fnp-5377	69	4	mutations	mutation	NOUN
fnp-5377	69	5	in	in	ADP
fnp-5377	69	6	tp53	tp53	PROPN
fnp-5377	69	7	(	(	PUNCT
fnp-5377	69	8	c.818	c.818	NOUN
fnp-5377	69	9	g	g	NOUN
fnp-5377	69	10	>	>	X
fnp-5377	69	11	a	a	DET
fnp-5377	69	12	(	(	PUNCT
fnp-5377	69	13	p.arg273his	p.arg273his	NOUN
fnp-5377	69	14	)	)	PUNCT
fnp-5377	69	15	)	)	PUNCT
fnp-5377	69	16	;	;	PUNCT
fnp-5377	69	17	96.6	96.6	NUM
fnp-5377	69	18	%	%	NOUN
fnp-5377	69	19	vaf	vaf	NOUN
fnp-5377	69	20	(	(	PUNCT
fnp-5377	69	21	including	include	VERB
fnp-5377	69	22	copy	copy	VERB
fnp-5377	69	23	neutral	neutral	ADJ
fnp-5377	69	24	loh	loh	PROPN
fnp-5377	69	25	)	)	PUNCT
fnp-5377	69	26	,	,	PUNCT
fnp-5377	69	27	nf1	nf1	NOUN
fnp-5377	69	28	:	:	PUNCT
fnp-5377	69	29	c.4977_4980delctct	c.4977_4980delctct	NOUN
fnp-5377	69	30	(	(	PUNCT
fnp-5377	69	31	p.lys1661glyfs*36	p.lys1661glyfs*36	PROPN
fnp-5377	69	32	)	)	PUNCT
fnp-5377	69	33	;	;	PUNCT
fnp-5377	69	34	95.1	95.1	NUM
fnp-5377	69	35	%	%	NOUN
fnp-5377	69	36	vaf	vaf	NOUN
fnp-5377	69	37	(	(	PUNCT
fnp-5377	69	38	including	include	VERB
fnp-5377	69	39	copy	copy	VERB
fnp-5377	69	40	neutral	neutral	ADJ
fnp-5377	69	41	loh	loh	PROPN
fnp-5377	69	42	)	)	PUNCT
fnp-5377	69	43	and	and	CCONJ
fnp-5377	69	44	bcor	bcor	NOUN
fnp-5377	69	45	:	:	PUNCT
fnp-5377	69	46	c.4438c	c.4438c	PROPN
fnp-5377	69	47	>	>	X
fnp-5377	69	48	t	t	PROPN
fnp-5377	69	49	(	(	PUNCT
fnp-5377	69	50	p.arg1480	p.arg1480	NOUN
fnp-5377	69	51	*	*	NOUN
fnp-5377	69	52	)	)	PUNCT
fnp-5377	69	53	;	;	PUNCT
fnp-5377	69	54	93.7	93.7	NUM
fnp-5377	69	55	%	%	NOUN
fnp-5377	69	56	vaf	vaf	NOUN
fnp-5377	69	57	(	(	PUNCT
fnp-5377	69	58	including	include	VERB
fnp-5377	69	59	copy	copy	VERB
fnp-5377	69	60	neutral	neutral	ADJ
fnp-5377	69	61	loh	loh	PROPN
fnp-5377	69	62	)	)	PUNCT
fnp-5377	69	63	.	.	PUNCT
fnp-5377	70	1	furthermore	furthermore	ADV
fnp-5377	70	2	,	,	PUNCT
fnp-5377	70	3	the	the	DET
fnp-5377	70	4	known	know	VERB
fnp-5377	70	5	homozygous	homozygous	ADJ
fnp-5377	70	6	germline	germline	NOUN
fnp-5377	70	7	mutation	mutation	NOUN
fnp-5377	70	8	in	in	ADP
fnp-5377	70	9	l2hgdh	l2hgdh	ADJ
fnp-5377	70	10	(	(	PUNCT
fnp-5377	70	11	c.339	c.339	X
fnp-5377	70	12	t	t	PROPN
fnp-5377	70	13	>	>	X
fnp-5377	70	14	a	a	DET
fnp-5377	70	15	p.(cys113	p.(cys113	PROPN
fnp-5377	70	16	*	*	PUNCT
fnp-5377	70	17	)	)	PUNCT
fnp-5377	70	18	)	)	PUNCT
fnp-5377	70	19	was	be	AUX
fnp-5377	70	20	detected	detect	VERB
fnp-5377	70	21	in	in	ADP
fnp-5377	70	22	the	the	DET
fnp-5377	70	23	tumor	tumor	NOUN
fnp-5377	70	24	as	as	ADV
fnp-5377	70	25	well	well	ADV
fnp-5377	70	26	(	(	PUNCT
fnp-5377	70	27	100	100	NUM
fnp-5377	70	28	%	%	NOUN
fnp-5377	70	29	vaf	vaf	PROPN
fnp-5377	70	30	)	)	PUNCT
fnp-5377	70	31	.	.	PUNCT
fnp-5377	71	1	rna	rna	NOUN
fnp-5377	71	2	sequencing	sequencing	NOUN
fnp-5377	71	3	revealed	reveal	VERB
fnp-5377	71	4	no	no	DET
fnp-5377	71	5	additional	additional	ADJ
fnp-5377	71	6	mutations	mutation	NOUN
fnp-5377	71	7	or	or	CCONJ
fnp-5377	71	8	gene	gene	NOUN
fnp-5377	71	9	rearrangements	rearrangement	NOUN
fnp-5377	71	10	.	.	PUNCT
fnp-5377	72	1	rna	rna	NOUN
fnp-5377	72	2	levels	level	NOUN
fnp-5377	72	3	of	of	ADP
fnp-5377	72	4	l2hgdh	l2hgdh	NOUN
fnp-5377	72	5	in	in	ADP
fnp-5377	72	6	the	the	DET
fnp-5377	72	7	tumor	tumor	NOUN
fnp-5377	72	8	were	be	AUX
fnp-5377	72	9	comparable	comparable	ADJ
fnp-5377	72	10	to	to	ADP
fnp-5377	72	11	or	or	CCONJ
fnp-5377	72	12	even	even	ADV
fnp-5377	72	13	lower	low	ADJ
fnp-5377	72	14	than	than	ADP
fnp-5377	72	15	in	in	ADP
fnp-5377	72	16	other	other	ADJ
fnp-5377	72	17	pediatric	pediatric	ADJ
fnp-5377	72	18	tumors	tumor	NOUN
fnp-5377	72	19	in	in	ADP
fnp-5377	72	20	the	the	DET
fnp-5377	72	21	reference	reference	NOUN
fnp-5377	72	22	cohort	cohort	NOUN
fnp-5377	72	23	of	of	ADP
fnp-5377	72	24	the	the	DET
fnp-5377	72	25	princess	princess	ADJ
fnp-5377	72	26	maxima	maxima	NOUN
fnp-5377	72	27	center	center	NOUN
fnp-5377	72	28	(	(	PUNCT
fnp-5377	72	29	supplemental	supplemental	ADJ
fnp-5377	72	30	figure	figure	NOUN
fnp-5377	72	31	1	1	NUM
fnp-5377	72	32	)	)	PUNCT
fnp-5377	72	33	.	.	PUNCT
fnp-5377	73	1	unfortunately	unfortunately	ADV
fnp-5377	73	2	,	,	PUNCT
fnp-5377	73	3	there	there	PRON
fnp-5377	73	4	was	be	VERB
fnp-5377	73	5	no	no	DET
fnp-5377	73	6	tissue	tissue	NOUN
fnp-5377	73	7	left	leave	VERB
fnp-5377	73	8	for	for	ADP
fnp-5377	73	9	analysis	analysis	NOUN
fnp-5377	73	10	of	of	ADP
fnp-5377	73	11	l2hgdh	l2hgdh	ADJ
fnp-5377	73	12	protein	protein	NOUN
fnp-5377	73	13	levels	level	NOUN
fnp-5377	73	14	in	in	ADP
fnp-5377	73	15	the	the	DET
fnp-5377	73	16	tumor	tumor	NOUN
fnp-5377	73	17	.	.	PUNCT
fnp-5377	74	1	acknowledging	acknowledge	VERB
fnp-5377	74	2	that	that	SCONJ
fnp-5377	74	3	in	in	ADP
fnp-5377	74	4	idh	idh	NOUN
fnp-5377	74	5	-	-	PUNCT
fnp-5377	74	6	mutant	mutant	ADJ
fnp-5377	74	7	tumors	tumor	NOUN
fnp-5377	74	8	high	high	ADJ
fnp-5377	74	9	levels	level	NOUN
fnp-5377	74	10	of	of	ADP
fnp-5377	74	11	d-2	d-2	NOUN
fnp-5377	74	12	-	-	PUNCT
fnp-5377	74	13	hg	hg	NOUN
fnp-5377	74	14	(	(	PUNCT
fnp-5377	74	15	the	the	DET
fnp-5377	74	16	enantiomer	enantiomer	NOUN
fnp-5377	74	17	of	of	ADP
fnp-5377	74	18	l-2	l-2	PROPN
fnp-5377	74	19	-	-	PUNCT
fnp-5377	74	20	hg	hg	NOUN
fnp-5377	74	21	)	)	PUNCT
fnp-5377	74	22	result	result	VERB
fnp-5377	74	23	in	in	ADP
fnp-5377	74	24	hypermethylation	hypermethylation	NOUN
fnp-5377	74	25	and	and	CCONJ
fnp-5377	74	26	g	g	NOUN
fnp-5377	74	27	-	-	PUNCT
fnp-5377	74	28	cimp9	cimp9	NOUN
fnp-5377	74	29	,	,	PUNCT
fnp-5377	74	30	14	14	NUM
fnp-5377	74	31	,	,	PUNCT
fnp-5377	74	32	we	we	PRON
fnp-5377	74	33	investigated	investigate	VERB
fnp-5377	74	34	whether	whether	SCONJ
fnp-5377	74	35	cimp	cimp	NOUN
fnp-5377	74	36	was	be	AUX
fnp-5377	74	37	present	present	ADJ
fnp-5377	74	38	in	in	ADP
fnp-5377	74	39	the	the	DET
fnp-5377	74	40	tumor	tumor	NOUN
fnp-5377	74	41	of	of	ADP
fnp-5377	74	42	our	our	PRON
fnp-5377	74	43	patient	patient	NOUN
fnp-5377	74	44	with	with	ADP
fnp-5377	74	45	l-2	l-2	PROPN
fnp-5377	74	46	-	-	PUNCT
fnp-5377	74	47	hga	hga	PROPN
fnp-5377	74	48	as	as	ADV
fnp-5377	74	49	well	well	ADV
fnp-5377	74	50	.	.	PUNCT
fnp-5377	75	1	however	however	ADV
fnp-5377	75	2	,	,	PUNCT
fnp-5377	75	3	unsupervised	unsupervised	ADJ
fnp-5377	75	4	analysis	analysis	NOUN
fnp-5377	75	5	using	use	VERB
fnp-5377	75	6	the	the	DET
fnp-5377	75	7	1000	1000	NUM
fnp-5377	75	8	most	most	ADV
fnp-5377	75	9	variable	variable	ADJ
fnp-5377	75	10	probes	probe	NOUN
fnp-5377	75	11	of	of	ADP
fnp-5377	75	12	a	a	DET
fnp-5377	75	13	cohort	cohort	NOUN
fnp-5377	75	14	of	of	ADP
fnp-5377	75	15	435	435	NUM
fnp-5377	75	16	idh	idh	NOUN
fnp-5377	75	17	-	-	PUNCT
fnp-5377	75	18	mutant	mutant	NOUN
fnp-5377	75	19	and	and	CCONJ
fnp-5377	75	20	215	215	NUM
fnp-5377	75	21	idh	idh	NOUN
fnp-5377	75	22	-	-	PUNCT
fnp-5377	75	23	wildtype	wildtype	NOUN
fnp-5377	75	24	gliomas15	gliomas15	NOUN
fnp-5377	75	25	revealed	reveal	VERB
fnp-5377	75	26	that	that	SCONJ
fnp-5377	75	27	the	the	DET
fnp-5377	75	28	tumor	tumor	NOUN
fnp-5377	75	29	of	of	ADP
fnp-5377	75	30	our	our	PRON
fnp-5377	75	31	patient	patient	NOUN
fnp-5377	75	32	clustered	cluster	VERB
fnp-5377	75	33	amongst	amongst	ADP
fnp-5377	75	34	the	the	DET
fnp-5377	75	35	idh	idh	NOUN
fnp-5377	75	36	-	-	PUNCT
fnp-5377	75	37	wildtype	wildtype	NOUN
fnp-5377	75	38	tumors	tumor	NOUN
fnp-5377	75	39	(	(	PUNCT
fnp-5377	75	40	figure	figure	VERB
fnp-5377	75	41	3c	3c	NUM
fnp-5377	75	42	)	)	PUNCT
fnp-5377	75	43	and	and	CCONJ
fnp-5377	75	44	had	have	VERB
fnp-5377	75	45	relative	relative	ADJ
fnp-5377	75	46	low	low	ADJ
fnp-5377	75	47	methylation	methylation	NOUN
fnp-5377	75	48	levels	level	NOUN
fnp-5377	75	49	(	(	PUNCT
fnp-5377	75	50	figure	figure	NOUN
fnp-5377	75	51	3d	3d	NUM
fnp-5377	75	52	)	)	PUNCT
fnp-5377	75	53	.	.	PUNCT
fnp-5377	76	1	follow	follow	VERB
fnp-5377	76	2	up	up	ADP
fnp-5377	76	3	given	give	VERB
fnp-5377	76	4	the	the	DET
fnp-5377	76	5	dismal	dismal	ADJ
fnp-5377	76	6	prognosis	prognosis	NOUN
fnp-5377	76	7	,	,	PUNCT
fnp-5377	76	8	which	which	PRON
fnp-5377	76	9	was	be	AUX
fnp-5377	76	10	partly	partly	ADV
fnp-5377	76	11	attributed	attribute	VERB
fnp-5377	76	12	to	to	ADP
fnp-5377	76	13	the	the	DET
fnp-5377	76	14	large	large	ADJ
fnp-5377	76	15	size	size	NOUN
fnp-5377	76	16	of	of	ADP
fnp-5377	76	17	the	the	DET
fnp-5377	76	18	tumor	tumor	NOUN
fnp-5377	76	19	,	,	PUNCT
fnp-5377	76	20	a	a	DET
fnp-5377	76	21	restrained	restrained	ADJ
fnp-5377	76	22	treatment	treatment	NOUN
fnp-5377	76	23	policy	policy	NOUN
fnp-5377	76	24	was	be	AUX
fnp-5377	76	25	chosen	choose	VERB
fnp-5377	76	26	.	.	PUNCT
fnp-5377	77	1	following	follow	VERB
fnp-5377	77	2	the	the	DET
fnp-5377	77	3	acns	acns	ADJ
fnp-5377	77	4	0126	0126	NUM
fnp-5377	77	5	protocol	protocol	NOUN
fnp-5377	77	6	,	,	PUNCT
fnp-5377	77	7	the	the	DET
fnp-5377	77	8	patient	patient	NOUN
fnp-5377	77	9	began	begin	VERB
fnp-5377	77	10	treatment	treatment	NOUN
fnp-5377	77	11	with	with	ADP
fnp-5377	77	12	temodal	temodal	ADJ
fnp-5377	77	13	two	two	NUM
fnp-5377	77	14	months	month	NOUN
fnp-5377	77	15	after	after	ADP
fnp-5377	77	16	diagnosis	diagnosis	NOUN
fnp-5377	77	17	,	,	PUNCT
fnp-5377	77	18	for	for	ADP
fnp-5377	77	19	stabilization	stabilization	NOUN
fnp-5377	77	20	of	of	ADP
fnp-5377	77	21	the	the	DET
fnp-5377	77	22	tumor	tumor	NOUN
fnp-5377	77	23	,	,	PUNCT
fnp-5377	77	24	in	in	ADP
fnp-5377	77	25	addition	addition	NOUN
fnp-5377	77	26	to	to	ADP
fnp-5377	77	27	dexamethasone	dexamethasone	NOUN
fnp-5377	77	28	for	for	ADP
fnp-5377	77	29	edema	edema	NOUN
fnp-5377	77	30	relief	relief	NOUN
fnp-5377	77	31	.	.	PUNCT
fnp-5377	78	1	unfortunately	unfortunately	ADV
fnp-5377	78	2	,	,	PUNCT
fnp-5377	78	3	in	in	ADP
fnp-5377	78	4	the	the	DET
fnp-5377	78	5	course	course	NOUN
fnp-5377	78	6	of	of	ADP
fnp-5377	78	7	the	the	DET
fnp-5377	78	8	following	following	ADJ
fnp-5377	78	9	months	month	NOUN
fnp-5377	78	10	the	the	DET
fnp-5377	78	11	condition	condition	NOUN
fnp-5377	78	12	of	of	ADP
fnp-5377	78	13	the	the	DET
fnp-5377	78	14	patient	patient	NOUN
fnp-5377	78	15	rapidly	rapidly	ADV
fnp-5377	78	16	worsened	worsen	VERB
fnp-5377	78	17	,	,	PUNCT
fnp-5377	78	18	leading	lead	VERB
fnp-5377	78	19	to	to	ADP
fnp-5377	78	20	her	her	PRON
fnp-5377	78	21	death	death	NOUN
fnp-5377	78	22	nine	nine	NUM
fnp-5377	78	23	months	month	NOUN
fnp-5377	78	24	after	after	ADP
fnp-5377	78	25	the	the	DET
fnp-5377	78	26	diagnosis	diagnosis	NOUN
fnp-5377	78	27	of	of	ADP
fnp-5377	78	28	the	the	DET
fnp-5377	78	29	cns	cns	NOUN
fnp-5377	78	30	tumor	tumor	NOUN
fnp-5377	78	31	.	.	PUNCT
fnp-5377	79	1	literature	literature	PROPN
fnp-5377	79	2	review	review	PROPN
fnp-5377	79	3	of	of	ADP
fnp-5377	79	4	l-2	l-2	PROPN
fnp-5377	79	5	-	-	PUNCT
fnp-5377	79	6	hga	hga	PROPN
fnp-5377	79	7	related	relate	VERB
fnp-5377	79	8	cns	cns	NOUN
fnp-5377	79	9	tumors	tumor	NOUN
fnp-5377	79	10	the	the	DET
fnp-5377	79	11	association	association	NOUN
fnp-5377	79	12	of	of	ADP
fnp-5377	79	13	l-2	l-2	PROPN
fnp-5377	79	14	-	-	PUNCT
fnp-5377	79	15	hga	hga	PROPN
fnp-5377	79	16	and	and	CCONJ
fnp-5377	79	17	cns	cns	PROPN
fnp-5377	79	18	tumors	tumor	NOUN
fnp-5377	79	19	has	have	AUX
fnp-5377	79	20	been	be	AUX
fnp-5377	79	21	documented	document	VERB
fnp-5377	79	22	in	in	ADP
fnp-5377	79	23	the	the	DET
fnp-5377	79	24	literature	literature	NOUN
fnp-5377	79	25	,	,	PUNCT
fnp-5377	79	26	with	with	ADP
fnp-5377	79	27	an	an	DET
fnp-5377	79	28	estimated	estimate	VERB
fnp-5377	79	29	rate	rate	NOUN
fnp-5377	79	30	of	of	ADP
fnp-5377	79	31	association	association	NOUN
fnp-5377	79	32	of	of	ADP
fnp-5377	79	33	5	5	NUM
fnp-5377	79	34	%	%	NOUN
fnp-5377	79	35	to	to	ADP
fnp-5377	79	36	40	40	NUM
fnp-5377	79	37	%	%	NOUN
fnp-5377	79	38	2	2	NUM
fnp-5377	79	39	according	accord	VERB
fnp-5377	79	40	to	to	ADP
fnp-5377	79	41	available	available	ADJ
fnp-5377	79	42	data	datum	NOUN
fnp-5377	79	43	(	(	PUNCT
fnp-5377	79	44	see	see	VERB
fnp-5377	79	45	table	table	NOUN
fnp-5377	79	46	1	1	NUM
fnp-5377	79	47	for	for	ADP
fnp-5377	79	48	a	a	DET
fnp-5377	79	49	compilation	compilation	NOUN
fnp-5377	79	50	of	of	ADP
fnp-5377	79	51	cases	case	NOUN
fnp-5377	79	52	in	in	ADP
fnp-5377	79	53	the	the	DET
fnp-5377	79	54	literature	literature	NOUN
fnp-5377	79	55	)	)	PUNCT
fnp-5377	79	56	.	.	PUNCT
fnp-5377	80	1	the	the	DET
fnp-5377	80	2	spectrum	spectrum	NOUN
fnp-5377	80	3	of	of	ADP
fnp-5377	80	4	cns	cns	PROPN
fnp-5377	80	5	tumors	tumor	NOUN
fnp-5377	80	6	reported	report	VERB
fnp-5377	80	7	to	to	PART
fnp-5377	80	8	be	be	AUX
fnp-5377	80	9	associated	associate	VERB
fnp-5377	80	10	with	with	ADP
fnp-5377	80	11	l-2	l-2	PROPN
fnp-5377	80	12	-	-	PUNCT
fnp-5377	80	13	hga	hga	NOUN
fnp-5377	80	14	includes	include	VERB
fnp-5377	80	15	medulloblastoma	medulloblastoma	NOUN
fnp-5377	80	16	in	in	ADP
fnp-5377	80	17	early	early	ADJ
fnp-5377	80	18	childhood	childhood	NOUN
fnp-5377	80	19	,	,	PUNCT
fnp-5377	80	20	anaplastic	anaplastic	ADJ
fnp-5377	80	21	ependymoma	ependymoma	NOUN
fnp-5377	80	22	predominantly	predominantly	ADV
fnp-5377	80	23	in	in	ADP
fnp-5377	80	24	teenagers	teenager	NOUN
fnp-5377	80	25	,	,	PUNCT
fnp-5377	80	26	lowand	lowand	ADJ
fnp-5377	80	27	high	high	ADJ
fnp-5377	80	28	-	-	PUNCT
fnp-5377	80	29	grade	grade	NOUN
fnp-5377	80	30	gliomas	glioma	NOUN
fnp-5377	80	31	in	in	ADP
fnp-5377	80	32	both	both	CCONJ
fnp-5377	80	33	childhood	childhood	NOUN
fnp-5377	80	34	and	and	CCONJ
fnp-5377	80	35	adults	adult	NOUN
fnp-5377	80	36	,	,	PUNCT
fnp-5377	80	37	and	and	CCONJ
fnp-5377	80	38	embryonal	embryonal	ADJ
fnp-5377	80	39	tumors	tumor	NOUN
fnp-5377	80	40	(	(	PUNCT
fnp-5377	80	41	previously	previously	ADV
fnp-5377	80	42	designated	designate	VERB
fnp-5377	80	43	as	as	ADP
fnp-5377	80	44	“	"	PUNCT
fnp-5377	80	45	primitive	primitive	ADJ
fnp-5377	80	46	neuroectodermal	neuroectodermal	ADJ
fnp-5377	80	47	tumor”/pnets	tumor”/pnet	NOUN
fnp-5377	80	48	)	)	PUNCT
fnp-5377	80	49	.	.	PUNCT
fnp-5377	81	1	apart	apart	ADV
fnp-5377	81	2	from	from	ADP
fnp-5377	81	3	medulloblastomas	medulloblastoma	NOUN
fnp-5377	81	4	(	(	PUNCT
fnp-5377	81	5	which	which	PRON
fnp-5377	81	6	by	by	ADP
fnp-5377	81	7	definition	definition	NOUN
fnp-5377	81	8	arise	arise	NOUN
fnp-5377	81	9	in	in	ADP
fnp-5377	81	10	the	the	DET
fnp-5377	81	11	posterior	posterior	ADJ
fnp-5377	81	12	fossa	fossa	NOUN
fnp-5377	81	13	)	)	PUNCT
fnp-5377	81	14	,	,	PUNCT
fnp-5377	81	15	l-2	l-2	PROPN
fnp-5377	81	16	-	-	PUNCT
fnp-5377	81	17	hga	hga	PROPN
fnp-5377	81	18	tumors	tumor	NOUN
fnp-5377	81	19	are	be	AUX
fnp-5377	81	20	often	often	ADV
fnp-5377	81	21	located	locate	VERB
fnp-5377	81	22	in	in	ADP
fnp-5377	81	23	a	a	DET
fnp-5377	81	24	cerebral	cerebral	ADJ
fnp-5377	81	25	hemisphere	hemisphere	NOUN
fnp-5377	81	26	(	(	PUNCT
fnp-5377	81	27	frontal	frontal	ADJ
fnp-5377	81	28	lobe	lobe	NOUN
fnp-5377	81	29	,	,	PUNCT
fnp-5377	81	30	temporal	temporal	ADJ
fnp-5377	81	31	lobe	lobe	NOUN
fnp-5377	81	32	and/or	and/or	CCONJ
fnp-5377	81	33	thalamus	thalamus	VERB
fnp-5377	81	34	)	)	PUNCT
fnp-5377	81	35	,	,	PUNCT
fnp-5377	81	36	but	but	CCONJ
fnp-5377	81	37	rarely	rarely	ADV
fnp-5377	81	38	in	in	ADP
fnp-5377	81	39	the	the	DET
fnp-5377	81	40	hippocampus	hippocampus	NOUN
fnp-5377	81	41	or	or	CCONJ
fnp-5377	81	42	in	in	ADP
fnp-5377	81	43	the	the	DET
fnp-5377	81	44	ventricles	ventricle	NOUN
fnp-5377	81	45	.	.	PUNCT
fnp-5377	82	1	however	however	ADV
fnp-5377	82	2	,	,	PUNCT
fnp-5377	82	3	there	there	PRON
fnp-5377	82	4	is	be	VERB
fnp-5377	82	5	some	some	DET
fnp-5377	82	6	missing	missing	ADJ
fnp-5377	82	7	data	datum	NOUN
fnp-5377	82	8	in	in	ADP
fnp-5377	82	9	the	the	DET
fnp-5377	82	10	cases	case	NOUN
fnp-5377	82	11	described	describe	VERB
fnp-5377	82	12	in	in	ADP
fnp-5377	82	13	the	the	DET
fnp-5377	82	14	literature	literature	NOUN
fnp-5377	82	15	:	:	PUNCT
fnp-5377	82	16	in	in	ADP
fnp-5377	82	17	one	one	NUM
fnp-5377	82	18	case	case	NOUN
fnp-5377	82	19	the	the	DET
fnp-5377	82	20	tumor	tumor	NOUN
fnp-5377	82	21	diagnosis	diagnosis	NOUN
fnp-5377	82	22	is	be	AUX
fnp-5377	82	23	not	not	PART
fnp-5377	82	24	described	describe	VERB
fnp-5377	82	25	,	,	PUNCT
fnp-5377	82	26	in	in	ADP
fnp-5377	82	27	three	three	NUM
fnp-5377	82	28	cases	case	NOUN
fnp-5377	82	29	the	the	DET
fnp-5377	82	30	age	age	NOUN
fnp-5377	82	31	is	be	AUX
fnp-5377	82	32	lacking	lack	VERB
fnp-5377	82	33	,	,	PUNCT
fnp-5377	82	34	in	in	ADP
fnp-5377	82	35	four	four	NUM
fnp-5377	82	36	cases	case	NOUN
fnp-5377	82	37	information	information	NOUN
fnp-5377	82	38	regarding	regard	VERB
fnp-5377	82	39	the	the	DET
fnp-5377	82	40	sex	sex	NOUN
fnp-5377	82	41	is	be	AUX
fnp-5377	82	42	not	not	PART
fnp-5377	82	43	reported	report	VERB
fnp-5377	82	44	and	and	CCONJ
fnp-5377	82	45	most	most	ADJ
fnp-5377	82	46	cases	case	NOUN
fnp-5377	82	47	do	do	AUX
fnp-5377	82	48	not	not	PART
fnp-5377	82	49	entail	entail	VERB
fnp-5377	82	50	survival	survival	ADJ
fnp-5377	82	51	data	datum	NOUN
fnp-5377	82	52	.	.	PUNCT
fnp-5377	83	1	it	it	PRON
fnp-5377	83	2	is	be	AUX
fnp-5377	83	3	worth	worth	ADJ
fnp-5377	83	4	noting	note	VERB
fnp-5377	83	5	that	that	SCONJ
fnp-5377	83	6	translating	translate	VERB
fnp-5377	83	7	previously	previously	ADV
fnp-5377	83	8	assigned	assign	VERB
fnp-5377	83	9	diagnoses	diagnosis	NOUN
fnp-5377	83	10	for	for	ADP
fnp-5377	83	11	cns	cns	PROPN
fnp-5377	83	12	tumors	tumor	NOUN
fnp-5377	83	13	associated	associate	VERB
fnp-5377	83	14	with	with	ADP
fnp-5377	83	15	l-2	l-2	PROPN
fnp-5377	83	16	-	-	PUNCT
fnp-5377	83	17	hga	hga	PROPN
fnp-5377	83	18	(	(	PUNCT
fnp-5377	83	19	table	table	NOUN
fnp-5377	83	20	1	1	NUM
fnp-5377	83	21	)	)	PUNCT
fnp-5377	83	22	into	into	ADP
fnp-5377	83	23	labels	label	NOUN
fnp-5377	83	24	conforming	conform	VERB
fnp-5377	83	25	to	to	ADP
fnp-5377	83	26	who	who	PRON
fnp-5377	83	27	cns	cns	PROPN
fnp-5377	83	28	5	5	NUM
fnp-5377	83	29	criteria	criterion	NOUN
fnp-5377	83	30	poses	pose	VERB
fnp-5377	83	31	some	some	DET
fnp-5377	83	32	challenges.16,17	challenges.16,17	NOUN
fnp-5377	83	33	for	for	ADP
fnp-5377	83	34	example	example	NOUN
fnp-5377	83	35	,	,	PUNCT
fnp-5377	83	36	the	the	DET
fnp-5377	83	37	tumors	tumor	NOUN
fnp-5377	83	38	of	of	ADP
fnp-5377	83	39	patients	patient	NOUN
fnp-5377	83	40	13	13	NUM
fnp-5377	83	41	and	and	CCONJ
fnp-5377	83	42	20	20	NUM
fnp-5377	83	43	in	in	ADP
fnp-5377	83	44	table	table	NOUN
fnp-5377	83	45	1	1	NUM
fnp-5377	83	46	were	be	AUX
fnp-5377	83	47	diagnosed	diagnose	VERB
fnp-5377	83	48	as	as	ADP
fnp-5377	83	49	glioblastoma	glioblastoma	NOUN
fnp-5377	83	50	,	,	PUNCT
fnp-5377	83	51	while	while	SCONJ
fnp-5377	83	52	according	accord	VERB
fnp-5377	83	53	to	to	ADP
fnp-5377	83	54	the	the	PRON
fnp-5377	83	55	who	who	PRON
fnp-5377	83	56	cns	cns	VERB
fnp-5377	83	57	5	5	NUM
fnp-5377	83	58	classification	classification	NOUN
fnp-5377	83	59	they	they	PRON
fnp-5377	83	60	would	would	AUX
fnp-5377	83	61	likely	likely	ADV
fnp-5377	83	62	be	be	AUX
fnp-5377	83	63	classified	classify	VERB
fnp-5377	83	64	as	as	ADP
fnp-5377	83	65	diffuse	diffuse	NOUN
fnp-5377	83	66	pediatric	pediatric	ADJ
fnp-5377	83	67	-	-	PUNCT
fnp-5377	83	68	type	type	NOUN
fnp-5377	83	69	high	high	ADJ
fnp-5377	83	70	-	-	PUNCT
fnp-5377	83	71	grade	grade	NOUN
fnp-5377	83	72	glioma	glioma	NOUN
fnp-5377	83	73	,	,	PUNCT
fnp-5377	83	74	h3	h3	NOUN
fnp-5377	83	75	-	-	PUNCT
fnp-5377	83	76	wildtype	wildtype	NOUN
fnp-5377	83	77	and	and	CCONJ
fnp-5377	83	78	idh	idh	NOUN
fnp-5377	83	79	-	-	PUNCT
fnp-5377	83	80	wildtype	wildtype	NOUN
fnp-5377	83	81	.	.	PUNCT
fnp-5377	84	1	additionally	additionally	ADV
fnp-5377	84	2	,	,	PUNCT
fnp-5377	84	3	no	no	DET
fnp-5377	84	4	idh	idh	NOUN
fnp-5377	84	5	status	status	NOUN
fnp-5377	84	6	was	be	AUX
fnp-5377	84	7	reported	report	VERB
fnp-5377	84	8	in	in	ADP
fnp-5377	84	9	the	the	DET
fnp-5377	84	10	astrocytoma	astrocytoma	NOUN
fnp-5377	84	11	or	or	CCONJ
fnp-5377	84	12	oligodendroglioma	oligodendroglioma	ADJ
fnp-5377	84	13	cases	case	NOUN
fnp-5377	84	14	,	,	PUNCT
fnp-5377	84	15	which	which	PRON
fnp-5377	84	16	is	be	AUX
fnp-5377	84	17	an	an	DET
fnp-5377	84	18	essential	essential	ADJ
fnp-5377	84	19	piece	piece	NOUN
fnp-5377	84	20	of	of	ADP
fnp-5377	84	21	information	information	NOUN
fnp-5377	84	22	for	for	ADP
fnp-5377	84	23	a	a	DET
fnp-5377	84	24	correct	correct	ADJ
fnp-5377	84	25	diagnosis	diagnosis	NOUN
fnp-5377	84	26	of	of	ADP
fnp-5377	84	27	diffuse	diffuse	ADJ
fnp-5377	84	28	gliomas	glioma	NOUN
fnp-5377	84	29	nowadays	nowadays	ADV
fnp-5377	84	30	.	.	PUNCT
fnp-5377	85	1	also	also	ADV
fnp-5377	85	2	,	,	PUNCT
fnp-5377	85	3	the	the	DET
fnp-5377	85	4	case	case	NOUN
fnp-5377	85	5	regarded	regard	VERB
fnp-5377	85	6	as	as	ADP
fnp-5377	85	7	ependymoma	ependymoma	NOUN
fnp-5377	85	8	and	and	CCONJ
fnp-5377	85	9	even	even	ADV
fnp-5377	85	10	the	the	DET
fnp-5377	85	11	embryonal	embryonal	ADJ
fnp-5377	85	12	tumors	tumor	NOUN
fnp-5377	85	13	may	may	AUX
fnp-5377	85	14	turn	turn	VERB
fnp-5377	85	15	out	out	ADP
fnp-5377	85	16	to	to	PART
fnp-5377	85	17	be	be	AUX
fnp-5377	85	18	high	high	ADJ
fnp-5377	85	19	grade	grade	NOUN
fnp-5377	85	20	gliomas.18	gliomas.18	VERB
fnp-5377	85	21	all	all	PRON
fnp-5377	85	22	in	in	ADP
fnp-5377	85	23	all	all	PRON
fnp-5377	85	24	,	,	PUNCT
fnp-5377	85	25	it	it	PRON
fnp-5377	85	26	is	be	AUX
fnp-5377	85	27	therefore	therefore	ADV
fnp-5377	85	28	difficult	difficult	ADJ
fnp-5377	85	29	to	to	PART
fnp-5377	85	30	associate	associate	VERB
fnp-5377	85	31	a	a	DET
fnp-5377	85	32	specific	specific	ADJ
fnp-5377	85	33	tumor	tumor	NOUN
fnp-5377	85	34	type	type	NOUN
fnp-5377	85	35	with	with	ADP
fnp-5377	85	36	l-2	l-2	PROPN
fnp-5377	85	37	-	-	PUNCT
fnp-5377	85	38	hga	hga	PROPN
fnp-5377	85	39	.	.	PUNCT
fnp-5377	86	1	discussion	discussion	NOUN
fnp-5377	86	2	in	in	ADP
fnp-5377	86	3	this	this	DET
fnp-5377	86	4	report	report	NOUN
fnp-5377	86	5	,	,	PUNCT
fnp-5377	86	6	we	we	PRON
fnp-5377	86	7	present	present	VERB
fnp-5377	86	8	a	a	DET
fnp-5377	86	9	teenager	teenager	NOUN
fnp-5377	86	10	with	with	ADP
fnp-5377	86	11	l-2	l-2	PROPN
fnp-5377	86	12	-	-	PUNCT
fnp-5377	86	13	hga	hga	PROPN
fnp-5377	86	14	who	who	PRON
fnp-5377	86	15	developed	develop	VERB
fnp-5377	86	16	a	a	DET
fnp-5377	86	17	temporal	temporal	ADJ
fnp-5377	86	18	lesion	lesion	NOUN
fnp-5377	86	19	,	,	PUNCT
fnp-5377	86	20	histomolecularly	histomolecularly	ADV
fnp-5377	86	21	classified	classify	VERB
fnp-5377	86	22	as	as	ADP
fnp-5377	86	23	diffuse	diffuse	NOUN
fnp-5377	86	24	pediatric	pediatric	ADJ
fnp-5377	86	25	-	-	PUNCT
fnp-5377	86	26	type	type	NOUN
fnp-5377	86	27	high	high	ADJ
fnp-5377	86	28	-	-	PUNCT
fnp-5377	86	29	grade	grade	NOUN
fnp-5377	86	30	glioma	glioma	NOUN
fnp-5377	86	31	,	,	PUNCT
fnp-5377	86	32	h3	h3	NOUN
fnp-5377	86	33	-	-	PUNCT
fnp-5377	86	34	wildtype	wildtype	NOUN
fnp-5377	86	35	,	,	PUNCT
fnp-5377	86	36	and	and	CCONJ
fnp-5377	86	37	idh	idh	NOUN
fnp-5377	86	38	-	-	PUNCT
fnp-5377	86	39	wildtype	wildtype	NOUN
fnp-5377	86	40	according	accord	VERB
fnp-5377	86	41	to	to	ADP
fnp-5377	86	42	the	the	DET
fnp-5377	86	43	who	who	PRON
fnp-5377	86	44	cns	cns	PROPN
fnp-5377	86	45	5	5	NUM
fnp-5377	86	46	criteria	criterion	NOUN
fnp-5377	86	47	.	.	PUNCT
fnp-5377	87	1	this	this	DET
fnp-5377	87	2	tumor	tumor	NOUN
fnp-5377	87	3	entity	entity	NOUN
fnp-5377	87	4	represents	represent	VERB
fnp-5377	87	5	a	a	DET
fnp-5377	87	6	group	group	NOUN
fnp-5377	87	7	of	of	ADP
fnp-5377	87	8	malignant	malignant	ADJ
fnp-5377	87	9	diffuse	diffuse	NOUN
fnp-5377	87	10	gliomas	glioma	NOUN
fnp-5377	87	11	,	,	PUNCT
fnp-5377	87	12	primarily	primarily	ADV
fnp-5377	87	13	occurring	occur	VERB
fnp-5377	87	14	in	in	ADP
fnp-5377	87	15	children	child	NOUN
fnp-5377	87	16	or	or	CCONJ
fnp-5377	87	17	young	young	ADJ
fnp-5377	87	18	adults	adult	NOUN
fnp-5377	87	19	that	that	PRON
fnp-5377	87	20	lack	lack	VERB
fnp-5377	87	21	alterations	alteration	NOUN
fnp-5377	87	22	in	in	ADP
fnp-5377	87	23	histone	histone	NOUN
fnp-5377	87	24	h3	h3	NOUN
fnp-5377	87	25	genes	gene	NOUN
fnp-5377	87	26	,	,	PUNCT
fnp-5377	87	27	as	as	ADV
fnp-5377	87	28	well	well	ADV
fnp-5377	87	29	as	as	ADP
fnp-5377	87	30	in	in	ADP
fnp-5377	87	31	idh1	idh1	PROPN
fnp-5377	87	32	and	and	CCONJ
fnp-5377	87	33	idh2	idh2	PROPN
fnp-5377	87	34	.	.	PUNCT
fnp-5377	88	1	the	the	DET
fnp-5377	88	2	molecular	molecular	ADJ
fnp-5377	88	3	alterations	alteration	NOUN
fnp-5377	88	4	in	in	ADP
fnp-5377	88	5	this	this	DET
fnp-5377	88	6	group	group	NOUN
fnp-5377	88	7	of	of	ADP
fnp-5377	88	8	tumors	tumor	NOUN
fnp-5377	88	9	are	be	AUX
fnp-5377	88	10	diverse	diverse	ADJ
fnp-5377	88	11	and	and	CCONJ
fnp-5377	88	12	include	include	VERB
fnp-5377	88	13	tp53	tp53	PROPN
fnp-5377	88	14	mutations	mutation	NOUN
fnp-5377	88	15	,	,	PUNCT
fnp-5377	88	16	mycn	mycn	NOUN
fnp-5377	88	17	amplification	amplification	NOUN
fnp-5377	88	18	,	,	PUNCT
fnp-5377	88	19	pdgfra	pdgfra	NOUN
fnp-5377	88	20	,	,	PUNCT
fnp-5377	88	21	id2	id2	PROPN
fnp-5377	88	22	,	,	PUNCT
fnp-5377	88	23	nf1	nf1	NOUN
fnp-5377	88	24	or	or	CCONJ
fnp-5377	88	25	egfr	egfr	ADJ
fnp-5377	88	26	alterations	alteration	NOUN
fnp-5377	88	27	.	.	PUNCT
fnp-5377	89	1	by	by	ADP
fnp-5377	89	2	dna	dna	PROPN
fnp-5377	89	3	methylation	methylation	NOUN
fnp-5377	89	4	profiling	profiling	NOUN
fnp-5377	89	5	they	they	PRON
fnp-5377	89	6	comprise	comprise	VERB
fnp-5377	89	7	a	a	DET
fnp-5377	89	8	distinct	distinct	ADJ
fnp-5377	89	9	group	group	NOUN
fnp-5377	89	10	with	with	ADP
fnp-5377	89	11	several	several	ADJ
fnp-5377	89	12	molecular	molecular	ADJ
fnp-5377	89	13	subgroups	subgroup	NOUN
fnp-5377	89	14	(	(	PUNCT
fnp-5377	89	15	rtk1	rtk1	NOUN
fnp-5377	89	16	,	,	PUNCT
fnp-5377	89	17	rtk2	rtk2	NOUN
fnp-5377	89	18	and	and	CCONJ
fnp-5377	89	19	mycn).16,19	mycn).16,19	NOUN
fnp-5377	89	20	methylation	methylation	NOUN
fnp-5377	89	21	array	array	NOUN
fnp-5377	89	22	classification	classification	NOUN
fnp-5377	89	23	is	be	AUX
fnp-5377	89	24	based	base	VERB
fnp-5377	89	25	on	on	ADP
fnp-5377	89	26	“	"	PUNCT
fnp-5377	89	27	fingerprinting	fingerprint	VERB
fnp-5377	89	28	”	"	PUNCT
fnp-5377	89	29	the	the	DET
fnp-5377	89	30	methylome	methylome	NOUN
fnp-5377	89	31	of	of	ADP
fnp-5377	89	32	the	the	DET
fnp-5377	89	33	tumor	tumor	NOUN
fnp-5377	89	34	,	,	PUNCT
fnp-5377	89	35	and	and	CCONJ
fnp-5377	89	36	subsequently	subsequently	ADV
fnp-5377	89	37	mapping	map	VERB
fnp-5377	89	38	this	this	PRON
fnp-5377	89	39	to	to	ADP
fnp-5377	89	40	a	a	DET
fnp-5377	89	41	reference	reference	NOUN
fnp-5377	89	42	database.8	database.8	PROPN
fnp-5377	89	43	this	this	DET
fnp-5377	89	44	methylome	methylome	ADJ
fnp-5377	89	45	profile	profile	NOUN
fnp-5377	89	46	is	be	AUX
fnp-5377	89	47	a	a	DET
fnp-5377	89	48	combination	combination	NOUN
fnp-5377	89	49	of	of	ADP
fnp-5377	89	50	both	both	DET
fnp-5377	89	51	somatically	somatically	ADV
fnp-5377	89	52	acquired	acquire	VERB
fnp-5377	89	53	dna	dna	PROPN
fnp-5377	89	54	methylation	methylation	NOUN
fnp-5377	89	55	changes	change	NOUN
fnp-5377	89	56	as	as	ADV
fnp-5377	89	57	well	well	ADV
fnp-5377	89	58	as	as	ADP
fnp-5377	89	59	the	the	DET
fnp-5377	89	60	methylation	methylation	NOUN
fnp-5377	89	61	status	status	NOUN
fnp-5377	89	62	of	of	ADP
fnp-5377	89	63	the	the	DET
fnp-5377	89	64	cell	cell	NOUN
fnp-5377	89	65	of	of	ADP
fnp-5377	89	66	origin	origin	NOUN
fnp-5377	89	67	.	.	PUNCT
fnp-5377	90	1	noteworthy	noteworthy	ADJ
fnp-5377	90	2	,	,	PUNCT
fnp-5377	90	3	high	high	ADJ
fnp-5377	90	4	-	-	PUNCT
fnp-5377	90	5	grade	grade	NOUN
fnp-5377	90	6	gliomas	glioma	NOUN
fnp-5377	90	7	based	base	VERB
fnp-5377	90	8	on	on	ADP
fnp-5377	90	9	a	a	DET
fnp-5377	90	10	tumor	tumor	NOUN
fnp-5377	90	11	predisposition	predisposition	NOUN
fnp-5377	90	12	syndrome	syndrome	NOUN
fnp-5377	90	13	such	such	ADJ
fnp-5377	90	14	as	as	ADP
fnp-5377	90	15	mismatch	mismatch	ADJ
fnp-5377	90	16	repair	repair	NOUN
fnp-5377	90	17	(	(	PUNCT
fnp-5377	90	18	mmr	mmr	PROPN
fnp-5377	90	19	)	)	PUNCT
fnp-5377	90	20	deficiency	deficiency	NOUN
fnp-5377	90	21	or	or	CCONJ
fnp-5377	90	22	li	li	NOUN
fnp-5377	90	23	-	-	ADJ
fnp-5377	90	24	fraumeni	fraumeni	NOUN
fnp-5377	90	25	are	be	AUX
fnp-5377	90	26	often	often	ADV
fnp-5377	90	27	classified	classify	VERB
fnp-5377	90	28	as	as	ADP
fnp-5377	90	29	diffuse	diffuse	NOUN
fnp-5377	90	30	pediatric	pediatric	ADJ
fnp-5377	90	31	-	-	PUNCT
fnp-5377	90	32	type	type	NOUN
fnp-5377	90	33	high	high	ADJ
fnp-5377	90	34	-	-	PUNCT
fnp-5377	90	35	grade	grade	NOUN
fnp-5377	90	36	glioma	glioma	NOUN
fnp-5377	90	37	,	,	PUNCT
fnp-5377	90	38	h3	h3	NOUN
fnp-5377	90	39	-	-	PUNCT
fnp-5377	90	40	wildtype	wildtype	NOUN
fnp-5377	90	41	and	and	CCONJ
fnp-5377	90	42	idh	idh	NOUN
fnp-5377	90	43	-	-	PUNCT
fnp-5377	90	44	wildtype	wildtype	NOUN
fnp-5377	90	45	as	as	ADV
fnp-5377	90	46	well	well	ADV
fnp-5377	90	47	,	,	PUNCT
fnp-5377	90	48	although	although	SCONJ
fnp-5377	90	49	not	not	PART
fnp-5377	90	50	always	always	ADV
fnp-5377	90	51	with	with	ADP
fnp-5377	90	52	high	high	ADJ
fnp-5377	90	53	confidence	confidence	NOUN
fnp-5377	90	54	.	.	PUNCT
fnp-5377	91	1	capper	capper	NOUN
fnp-5377	91	2	et	et	PROPN
fnp-5377	91	3	al	al	PROPN
fnp-5377	91	4	.	.	PROPN
fnp-5377	91	5	described	describe	VERB
fnp-5377	91	6	that	that	SCONJ
fnp-5377	91	7	the	the	DET
fnp-5377	91	8	full	full	ADJ
fnp-5377	91	9	spectrum	spectrum	NOUN
fnp-5377	91	10	of	of	ADP
fnp-5377	91	11	tumors	tumor	NOUN
fnp-5377	91	12	in	in	ADP
fnp-5377	91	13	the	the	DET
fnp-5377	91	14	context	context	NOUN
fnp-5377	91	15	of	of	ADP
fnp-5377	91	16	a	a	DET
fnp-5377	91	17	hereditary	hereditary	ADJ
fnp-5377	91	18	predisposition	predisposition	NOUN
fnp-5377	91	19	syndrome	syndrome	NOUN
fnp-5377	91	20	may	may	AUX
fnp-5377	91	21	not	not	PART
fnp-5377	91	22	yet	yet	ADV
fnp-5377	91	23	be	be	AUX
fnp-5377	91	24	reliably	reliably	ADV
fnp-5377	91	25	classified.20	classified.20	NOUN
fnp-5377	91	26	in	in	ADP
fnp-5377	91	27	line	line	NOUN
fnp-5377	91	28	with	with	ADP
fnp-5377	91	29	this	this	PRON
fnp-5377	91	30	,	,	PUNCT
fnp-5377	91	31	the	the	DET
fnp-5377	91	32	tumor	tumor	NOUN
fnp-5377	91	33	we	we	PRON
fnp-5377	91	34	present	present	VERB
fnp-5377	91	35	here	here	ADV
fnp-5377	91	36	could	could	AUX
fnp-5377	91	37	also	also	ADV
fnp-5377	91	38	not	not	PART
fnp-5377	91	39	be	be	AUX
fnp-5377	91	40	classified	classify	VERB
fnp-5377	91	41	with	with	ADP
fnp-5377	91	42	confidence	confidence	NOUN
fnp-5377	91	43	.	.	PUNCT
fnp-5377	92	1	a	a	DET
fnp-5377	92	2	possible	possible	ADJ
fnp-5377	92	3	explanation	explanation	NOUN
fnp-5377	92	4	for	for	ADP
fnp-5377	92	5	classification	classification	NOUN
fnp-5377	92	6	difficulties	difficulty	NOUN
fnp-5377	92	7	might	might	AUX
fnp-5377	92	8	be	be	AUX
fnp-5377	92	9	that	that	SCONJ
fnp-5377	92	10	the	the	DET
fnp-5377	92	11	effect	effect	NOUN
fnp-5377	92	12	of	of	ADP
fnp-5377	92	13	the	the	DET
fnp-5377	92	14	germline	germline	NOUN
fnp-5377	92	15	alteration	alteration	NOUN
fnp-5377	92	16	,	,	PUNCT
fnp-5377	92	17	which	which	PRON
fnp-5377	92	18	is	be	AUX
fnp-5377	92	19	present	present	ADJ
fnp-5377	92	20	in	in	ADP
fnp-5377	92	21	all	all	DET
fnp-5377	92	22	cells	cell	NOUN
fnp-5377	92	23	,	,	PUNCT
fnp-5377	92	24	together	together	ADV
fnp-5377	92	25	with	with	ADP
fnp-5377	92	26	the	the	DET
fnp-5377	92	27	somewhat	somewhat	ADV
fnp-5377	92	28	different	different	ADJ
fnp-5377	92	29	oncogenesis	oncogenesis	NOUN
fnp-5377	92	30	alters	alter	VERB
fnp-5377	92	31	the	the	DET
fnp-5377	92	32	methylome	methylome	NOUN
fnp-5377	92	33	of	of	ADP
fnp-5377	92	34	the	the	DET
fnp-5377	92	35	cancer	cancer	NOUN
fnp-5377	92	36	in	in	ADP
fnp-5377	92	37	such	such	DET
fnp-5377	92	38	a	a	DET
fnp-5377	92	39	way	way	NOUN
fnp-5377	92	40	that	that	PRON
fnp-5377	92	41	it	it	PRON
fnp-5377	92	42	no	no	ADV
fnp-5377	92	43	longer	long	ADV
fnp-5377	92	44	fully	fully	ADV
fnp-5377	92	45	reflects	reflect	VERB
fnp-5377	92	46	the	the	DET
fnp-5377	92	47	methylome	methylome	ADJ
fnp-5377	92	48	profile	profile	NOUN
fnp-5377	92	49	of	of	ADP
fnp-5377	92	50	the	the	DET
fnp-5377	92	51	sporadic	sporadic	ADJ
fnp-5377	92	52	counterparts	counterpart	NOUN
fnp-5377	92	53	in	in	ADP
fnp-5377	92	54	the	the	DET
fnp-5377	92	55	reference	reference	NOUN
fnp-5377	92	56	cohort	cohort	NOUN
fnp-5377	92	57	.	.	PUNCT
fnp-5377	93	1	it	it	PRON
fnp-5377	93	2	remains	remain	VERB
fnp-5377	93	3	to	to	PART
fnp-5377	93	4	be	be	AUX
fnp-5377	93	5	seen	see	VERB
fnp-5377	93	6	if	if	SCONJ
fnp-5377	93	7	tumors	tumor	NOUN
fnp-5377	93	8	that	that	PRON
fnp-5377	93	9	arise	arise	VERB
fnp-5377	93	10	in	in	ADP
fnp-5377	93	11	the	the	DET
fnp-5377	93	12	context	context	NOUN
fnp-5377	93	13	of	of	ADP
fnp-5377	93	14	l-2	l-2	PROPN
fnp-5377	93	15	-	-	PUNCT
fnp-5377	93	16	hga	hga	PROPN
fnp-5377	93	17	are	be	AUX
fnp-5377	93	18	(	(	PUNCT
fnp-5377	93	19	also	also	ADV
fnp-5377	93	20	on	on	ADP
fnp-5377	93	21	the	the	DET
fnp-5377	93	22	epigenetic	epigenetic	ADJ
fnp-5377	93	23	level	level	NOUN
fnp-5377	93	24	)	)	PUNCT
fnp-5377	93	25	more	more	ADV
fnp-5377	93	26	similar	similar	ADJ
fnp-5377	93	27	to	to	ADP
fnp-5377	93	28	each	each	DET
fnp-5377	93	29	other	other	ADJ
fnp-5377	93	30	than	than	SCONJ
fnp-5377	93	31	suggested	suggest	VERB
fnp-5377	93	32	based	base	VERB
fnp-5377	93	33	on	on	ADP
fnp-5377	93	34	literature	literature	NOUN
fnp-5377	93	35	in	in	ADP
fnp-5377	93	36	the	the	DET
fnp-5377	93	37	pre	pre	ADJ
fnp-5377	93	38	-	-	ADJ
fnp-5377	93	39	molecular	molecular	ADJ
fnp-5377	93	40	era	era	NOUN
fnp-5377	93	41	(	(	PUNCT
fnp-5377	93	42	table	table	NOUN
fnp-5377	93	43	1	1	NUM
fnp-5377	93	44	)	)	PUNCT
fnp-5377	93	45	.	.	PUNCT
fnp-5377	94	1	methylation	methylation	NOUN
fnp-5377	94	2	analysis	analysis	NOUN
fnp-5377	94	3	of	of	ADP
fnp-5377	94	4	tumors	tumor	NOUN
fnp-5377	94	5	from	from	ADP
fnp-5377	94	6	additional	additional	ADJ
fnp-5377	94	7	l2	l2	NOUN
fnp-5377	94	8	-	-	PUNCT
fnp-5377	94	9	hga	hga	NOUN
fnp-5377	94	10	patients	patient	NOUN
fnp-5377	94	11	is	be	AUX
fnp-5377	94	12	necessary	necessary	ADJ
fnp-5377	94	13	for	for	ADP
fnp-5377	94	14	further	further	ADJ
fnp-5377	94	15	characterization	characterization	NOUN
fnp-5377	94	16	of	of	ADP
fnp-5377	94	17	l2	l2	NOUN
fnp-5377	94	18	-	-	PUNCT
fnp-5377	94	19	hga	hga	NOUN
fnp-5377	94	20	-	-	PUNCT
fnp-5377	94	21	associated	associate	VERB
fnp-5377	94	22	tumors	tumor	NOUN
fnp-5377	94	23	,	,	PUNCT
fnp-5377	94	24	and	and	CCONJ
fnp-5377	94	25	for	for	ADP
fnp-5377	94	26	corroborating	corroborate	VERB
fnp-5377	94	27	the	the	DET
fnp-5377	94	28	absence	absence	NOUN
fnp-5377	94	29	of	of	ADP
fnp-5377	94	30	g	g	NOUN
fnp-5377	94	31	-	-	PUNCT
fnp-5377	94	32	cimp	cimp	NOUN
fnp-5377	94	33	that	that	PRON
fnp-5377	94	34	we	we	PRON
fnp-5377	94	35	observed	observe	VERB
fnp-5377	94	36	in	in	ADP
fnp-5377	94	37	our	our	PRON
fnp-5377	94	38	case	case	NOUN
fnp-5377	94	39	.	.	PUNCT
fnp-5377	95	1	table	table	NOUN
fnp-5377	95	2	1	1	NUM
fnp-5377	95	3	:	:	PUNCT
fnp-5377	95	4	reported	report	VERB
fnp-5377	95	5	cns	cns	PROPN
fnp-5377	95	6	tumors	tumor	NOUN
fnp-5377	95	7	associated	associate	VERB
fnp-5377	95	8	with	with	ADP
fnp-5377	95	9	l-2	l-2	PROPN
fnp-5377	95	10	-	-	PUNCT
fnp-5377	95	11	hga	hga	PROPN
fnp-5377	95	12	case	case	NOUN
fnp-5377	95	13	sex	sex	NOUN
fnp-5377	95	14	 	 	SPACE
fnp-5377	95	15	/	/	SYM
fnp-5377	95	16	 	 	SPACE
fnp-5377	95	17	age	age	NOUN
fnp-5377	95	18	tumor	tumor	NOUN
fnp-5377	95	19	location	location	NOUN
fnp-5377	95	20	reported	report	VERB
fnp-5377	95	21	histological	histological	ADJ
fnp-5377	95	22	diagnosis	diagnosis	NOUN
fnp-5377	95	23	molecular	molecular	ADJ
fnp-5377	95	24	alteration	alteration	NOUN
fnp-5377	95	25	methylation	methylation	NOUN
fnp-5377	95	26	profile	profile	NOUN
fnp-5377	95	27	overall	overall	ADJ
fnp-5377	95	28	survival	survival	NOUN
fnp-5377	95	29	wilcken	wilcken	VERB
fnp-5377	95	30	et	et	PROPN
fnp-5377	95	31	al	al	PROPN
fnp-5377	95	32	.	.	PROPN
fnp-5377	95	33	199335	199335	NUM
fnp-5377	96	1	1	1	NUM
fnp-5377	96	2	f	f	X
fnp-5377	96	3	 	 	SPACE
fnp-5377	96	4	/	/	SYM
fnp-5377	96	5	 	 	SPACE
fnp-5377	96	6	15	15	NUM
fnp-5377	96	7	temporal	temporal	ADJ
fnp-5377	96	8	pnet	pnet	PROPN
fnp-5377	96	9	nd	nd	PRON
fnp-5377	96	10	nd	nd	ADV
fnp-5377	96	11	nm	nm	ADV
fnp-5377	96	12	barbot	barbot	NOUN
fnp-5377	96	13	et	et	PROPN
fnp-5377	96	14	al	al	PROPN
fnp-5377	96	15	.	.	PROPN
fnp-5377	96	16	199736	199736	NUM
fnp-5377	96	17	2	2	NUM
fnp-5377	96	18	f	f	X
fnp-5377	96	19	 	 	SPACE
fnp-5377	96	20	/	/	SYM
fnp-5377	96	21	 	 	SPACE
fnp-5377	96	22	10	10	NUM
fnp-5377	96	23	thalamus	thalamus	NOUN
fnp-5377	96	24	right	right	ADV
fnp-5377	96	25	fibrillar	fibrillar	ADJ
fnp-5377	96	26	diffuse	diffuse	PROPN
fnp-5377	96	27	astrocytoma	astrocytoma	PROPN
fnp-5377	96	28	nd	nd	ADP
fnp-5377	96	29	nd	nd	NOUN
fnp-5377	96	30	6	6	NUM
fnp-5377	96	31	months	month	NOUN
fnp-5377	96	32	wanders	wander	VERB
fnp-5377	96	33	et	et	PROPN
fnp-5377	96	34	al	al	PROPN
fnp-5377	96	35	.	.	PROPN
fnp-5377	97	1	199737	199737	NUM
fnp-5377	97	2	3	3	NUM
fnp-5377	97	3	f	f	X
fnp-5377	97	4	 	 	SPACE
fnp-5377	97	5	/	/	SYM
fnp-5377	97	6	 	 	SPACE
fnp-5377	97	7	9	9	NUM
fnp-5377	97	8	thalamus	thalamus	NOUN
fnp-5377	97	9	right	right	ADJ
fnp-5377	97	10	low	low	ADJ
fnp-5377	97	11	-	-	PUNCT
fnp-5377	97	12	grade	grade	NOUN
fnp-5377	97	13	astrocytoma	astrocytoma	NOUN
fnp-5377	97	14	nd	nd	ADP
fnp-5377	97	15	nd	nd	NOUN
fnp-5377	97	16	6	6	NUM
fnp-5377	97	17	months	month	NOUN
fnp-5377	97	18	ozisik	ozisik	PROPN
fnp-5377	97	19	et	et	PROPN
fnp-5377	97	20	al	al	PROPN
fnp-5377	97	21	.	.	PROPN
fnp-5377	97	22	200238	200238	NUM
fnp-5377	97	23	4	4	NUM
fnp-5377	97	24	m	m	VERB
fnp-5377	97	25	 	 	SPACE
fnp-5377	97	26	/	/	SYM
fnp-5377	97	27	 	 	SPACE
fnp-5377	97	28	3	3	NUM
fnp-5377	97	29	posterior	posterior	ADJ
fnp-5377	97	30	fossa	fossa	ADJ
fnp-5377	97	31	medulloblastoma	medulloblastoma	NOUN
fnp-5377	97	32	nd	nd	ADV
fnp-5377	97	33	nd	nd	NOUN
fnp-5377	97	34	6	6	NUM
fnp-5377	97	35	months	month	NOUN
fnp-5377	97	36	moroni	moroni	PROPN
fnp-5377	97	37	et	et	PROPN
fnp-5377	97	38	al	al	PROPN
fnp-5377	97	39	.	.	PROPN
fnp-5377	97	40	20045	20045	NUM
fnp-5377	97	41	5	5	NUM
fnp-5377	97	42	m	m	VERB
fnp-5377	97	43	 	 	SPACE
fnp-5377	97	44	/	/	SYM
fnp-5377	97	45	 	 	SPACE
fnp-5377	97	46	13,5	13,5	NUM
fnp-5377	97	47	temporal	temporal	ADJ
fnp-5377	97	48	right	right	PROPN
fnp-5377	97	49	pnet	pnet	PROPN
fnp-5377	97	50	nd	nd	ADV
fnp-5377	97	51	nd	nd	ADV
fnp-5377	97	52	alive	alive	ADJ
fnp-5377	97	53	at	at	ADP
fnp-5377	97	54	2	2	NUM
fnp-5377	97	55	years	year	NOUN
fnp-5377	97	56	fu	fu	ADJ
fnp-5377	97	57	6	6	NUM
fnp-5377	97	58	f	f	NOUN
fnp-5377	97	59	 	 	SPACE
fnp-5377	97	60	/	/	SYM
fnp-5377	97	61	 	 	SPACE
fnp-5377	97	62	26	26	NUM
fnp-5377	97	63	temporal	temporal	ADJ
fnp-5377	97	64	left	left	ADJ
fnp-5377	97	65	glioblastoma	glioblastoma	NOUN
fnp-5377	97	66	loh	loh	PROPN
fnp-5377	97	67	chrom	chrom	PROPN
fnp-5377	97	68	1p	1p	PROPN
fnp-5377	97	69	nd	nd	NOUN
fnp-5377	97	70	nm	nm	ADV
fnp-5377	97	71	7	7	NUM
fnp-5377	97	72	f	f	X
fnp-5377	97	73	 	 	SPACE
fnp-5377	97	74	/	/	SYM
fnp-5377	97	75	 	 	SPACE
fnp-5377	97	76	18	18	NUM
fnp-5377	97	77	temporal	temporal	ADJ
fnp-5377	97	78	right	right	INTJ
fnp-5377	97	79	nd	nd	INTJ
fnp-5377	97	80	nd	nd	INTJ
fnp-5377	97	81	nd	nd	ADV
fnp-5377	97	82	3	3	NUM
fnp-5377	97	83	years	year	NOUN
fnp-5377	97	84	8	8	NUM
fnp-5377	97	85	m	m	VERB
fnp-5377	97	86	 	 	SPACE
fnp-5377	97	87	/	/	SYM
fnp-5377	97	88	 	 	SPACE
fnp-5377	97	89	12	12	NUM
fnp-5377	97	90	frontal	frontal	ADJ
fnp-5377	97	91	left	leave	VERB
fnp-5377	97	92	low	low	ADJ
fnp-5377	97	93	-	-	PUNCT
fnp-5377	97	94	grade	grade	NOUN
fnp-5377	97	95	astrocytoma	astrocytoma	NOUN
fnp-5377	97	96	nd	nd	ADP
fnp-5377	97	97	nd	nd	ADV
fnp-5377	97	98	few	few	ADJ
fnp-5377	97	99	months	month	NOUN
fnp-5377	97	100	topcu	topcu	X
fnp-5377	97	101	et	et	PROPN
fnp-5377	97	102	al	al	PROPN
fnp-5377	97	103	.	.	PROPN
fnp-5377	97	104	200539	200539	NUM
fnp-5377	97	105	9	9	NUM
fnp-5377	97	106	nm	nm	NOUN
fnp-5377	97	107	 	 	SPACE
fnp-5377	97	108	/	/	SYM
fnp-5377	97	109	 	 	SPACE
fnp-5377	97	110	3	3	NUM
fnp-5377	97	111	nm	nm	NOUN
fnp-5377	97	112	medulloblastoma	medulloblastoma	NOUN
fnp-5377	97	113	nd	nd	ADV
fnp-5377	97	114	nd	nd	NOUN
fnp-5377	97	115	6	6	NUM
fnp-5377	97	116	months	month	NOUN
fnp-5377	97	117	vilarinho	vilarinho	NOUN
fnp-5377	97	118	 	 	SPACE
fnp-5377	97	119	et	et	PROPN
fnp-5377	97	120	 	 	SPACE
fnp-5377	97	121	al	al	PROPN
fnp-5377	97	122	.	.	PROPN
fnp-5377	97	123	 	 	SPACE
fnp-5377	97	124	200540	200540	NUM
fnp-5377	97	125	10	10	NUM
fnp-5377	97	126	nm	nm	NOUN
fnp-5377	97	127	 	 	SPACE
fnp-5377	97	128	/	/	SYM
fnp-5377	97	129	 	 	SPACE
fnp-5377	97	130	nm	nm	VERB
fnp-5377	97	131	nm	nm	ADJ
fnp-5377	97	132	astrocytoma	astrocytoma	NOUN
fnp-5377	97	133	nd	nd	ADV
fnp-5377	97	134	nd	nd	ADV
fnp-5377	97	135	nm	nm	ADJ
fnp-5377	97	136	11	11	NUM
fnp-5377	97	137	nm	nm	NOUN
fnp-5377	97	138	 	 	SPACE
fnp-5377	97	139	/	/	SYM
fnp-5377	97	140	 	 	SPACE
fnp-5377	97	141	nm	nm	VERB
fnp-5377	97	142	nm	nm	ADJ
fnp-5377	97	143	astrocytoma	astrocytoma	NOUN
fnp-5377	97	144	nd	nd	ADV
fnp-5377	97	145	nd	nd	NOUN
fnp-5377	97	146	nm	nm	PROPN
fnp-5377	97	147	12	12	NUM
fnp-5377	97	148	nm	nm	NOUN
fnp-5377	97	149	 	 	SPACE
fnp-5377	97	150	/	/	SYM
fnp-5377	97	151	 	 	SPACE
fnp-5377	97	152	nm	nm	VERB
fnp-5377	97	153	nm	nm	ADJ
fnp-5377	97	154	astrocytoma	astrocytoma	NOUN
fnp-5377	97	155	nd	nd	ADP
fnp-5377	97	156	nd	nd	NOUN
fnp-5377	97	157	nm	nm	ADV
fnp-5377	97	158	haliloglu	haliloglu	NOUN
fnp-5377	97	159	et	et	PROPN
fnp-5377	97	160	al	al	PROPN
fnp-5377	97	161	.	.	PROPN
fnp-5377	97	162	200841	200841	NUM
fnp-5377	97	163	13	13	NUM
fnp-5377	97	164	m	m	VERB
fnp-5377	97	165	 	 	SPACE
fnp-5377	97	166	/	/	SYM
fnp-5377	97	167	 	 	SPACE
fnp-5377	97	168	11	11	NUM
fnp-5377	97	169	temporoparietal	temporoparietal	ADJ
fnp-5377	97	170	right	right	ADJ
fnp-5377	97	171	glioblastoma	glioblastoma	NOUN
fnp-5377	97	172	nd	nd	ADP
fnp-5377	97	173	nd	nd	ADV
fnp-5377	97	174	nm	nm	ADV
fnp-5377	97	175	aghili	aghili	NOUN
fnp-5377	97	176	et	et	PROPN
fnp-5377	97	177	al	al	PROPN
fnp-5377	97	178	.	.	PROPN
fnp-5377	97	179	200942	200942	NUM
fnp-5377	97	180	14	14	NUM
fnp-5377	97	181	m	m	VERB
fnp-5377	97	182	 	 	SPACE
fnp-5377	97	183	/	/	SYM
fnp-5377	97	184	 	 	SPACE
fnp-5377	97	185	17	17	NUM
fnp-5377	97	186	frontal	frontal	ADJ
fnp-5377	97	187	anaplastic	anaplastic	ADJ
fnp-5377	97	188	ependymoma	ependymoma	NOUN
fnp-5377	97	189	nd	nd	INTJ
fnp-5377	97	190	nd	nd	VERB
fnp-5377	97	191	nm	nm	ADV
fnp-5377	97	192	patay	patay	NOUN
fnp-5377	97	193	et	et	PROPN
fnp-5377	97	194	al	al	PROPN
fnp-5377	97	195	.	.	PROPN
fnp-5377	97	196	20122	20122	NUM
fnp-5377	97	197	15	15	NUM
fnp-5377	97	198	m	m	NOUN
fnp-5377	97	199	 	 	SPACE
fnp-5377	97	200	/	/	SYM
fnp-5377	97	201	 	 	SPACE
fnp-5377	97	202	23	23	NUM
fnp-5377	97	203	hippocampus	hippocampus	NOUN
fnp-5377	97	204	right	right	ADJ
fnp-5377	97	205	anaplastic	anaplastic	ADJ
fnp-5377	97	206	astrocytoma	astrocytoma	NOUN
fnp-5377	97	207	nd	nd	ADP
fnp-5377	97	208	nd	nd	NOUN
fnp-5377	97	209	nm	nm	PROPN
fnp-5377	97	210	16	16	NUM
fnp-5377	97	211	m	m	VERB
fnp-5377	97	212	 	 	SPACE
fnp-5377	97	213	/	/	SYM
fnp-5377	97	214	 	 	SPACE
fnp-5377	97	215	19	19	NUM
fnp-5377	97	216	frontal	frontal	ADJ
fnp-5377	97	217	right	right	ADJ
fnp-5377	97	218	oligodendroglioma	oligodendroglioma	NOUN
fnp-5377	97	219	nd	nd	INTJ
fnp-5377	97	220	nd	nd	ADV
fnp-5377	97	221	nm	nm	ADJ
fnp-5377	97	222	17	17	NUM
fnp-5377	97	223	f	f	X
fnp-5377	97	224	 	 	SPACE
fnp-5377	97	225	/	/	SYM
fnp-5377	97	226	 	 	SPACE
fnp-5377	97	227	36	36	NUM
fnp-5377	97	228	thalamus	thalamus	NOUN
fnp-5377	97	229	left	leave	VERB
fnp-5377	97	230	low	low	ADJ
fnp-5377	97	231	-	-	PUNCT
fnp-5377	97	232	grade	grade	NOUN
fnp-5377	97	233	glioma	glioma	NOUN
fnp-5377	97	234	nd	nd	ADP
fnp-5377	97	235	nd	nd	NOUN
fnp-5377	97	236	nm	nm	INTJ
fnp-5377	97	237	london	london	PROPN
fnp-5377	97	238	et	et	PROPN
fnp-5377	97	239	al	al	PROPN
fnp-5377	97	240	.	.	PROPN
fnp-5377	97	241	201525	201525	NUM
fnp-5377	97	242	18	18	NUM
fnp-5377	97	243	m	m	NOUN
fnp-5377	97	244	 	 	SPACE
fnp-5377	97	245	/	/	SYM
fnp-5377	97	246	 	 	SPACE
fnp-5377	97	247	29	29	NUM
fnp-5377	97	248	both	both	DET
fnp-5377	97	249	hemispheres	hemisphere	NOUN
fnp-5377	97	250	,	,	PUNCT
fnp-5377	97	251	corpus	corpus	NOUN
fnp-5377	97	252	callosum	callosum	NOUN
fnp-5377	97	253	and	and	CCONJ
fnp-5377	97	254	brainstem	brainstem	NOUN
fnp-5377	97	255	gliomatosis	gliomatosis	NOUN
fnp-5377	97	256	cerebri	cerebri	NOUN
fnp-5377	97	257	nd	nd	NOUN
fnp-5377	97	258	nd	nd	NOUN
fnp-5377	97	259	3	3	NUM
fnp-5377	97	260	weeks	week	NOUN
fnp-5377	97	261	patay	patay	NOUN
fnp-5377	97	262	et	et	PROPN
fnp-5377	97	263	al	al	PROPN
fnp-5377	97	264	.	.	PROPN
fnp-5377	97	265	201521	201521	NUM
fnp-5377	97	266	19	19	NUM
fnp-5377	97	267	m	m	NOUN
fnp-5377	97	268	 	 	SPACE
fnp-5377	97	269	/	/	SYM
fnp-5377	97	270	 	 	SPACE
fnp-5377	97	271	22	22	NUM
fnp-5377	97	272	temporal	temporal	ADJ
fnp-5377	97	273	right	right	ADJ
fnp-5377	97	274	anaplastic	anaplastic	ADJ
fnp-5377	97	275	astrocytoma	astrocytoma	NOUN
fnp-5377	97	276	egfr	egfr	VERB
fnp-5377	97	277	amplification	amplification	NOUN
fnp-5377	97	278	nd	nd	PROPN
fnp-5377	97	279	2nd	2nd	ADJ
fnp-5377	97	280	tumor	tumor	NOUN
fnp-5377	97	281	after	after	ADP
fnp-5377	97	282	40	40	NUM
fnp-5377	97	283	months	month	NOUN
fnp-5377	97	284	tan	tan	INTJ
fnp-5377	97	285	et	et	PROPN
fnp-5377	97	286	al	al	PROPN
fnp-5377	97	287	.	.	PROPN
fnp-5377	97	288	201832	201832	NUM
fnp-5377	97	289	20	20	NUM
fnp-5377	97	290	f	f	X
fnp-5377	97	291	 	 	SPACE
fnp-5377	97	292	/	/	SYM
fnp-5377	97	293	 	 	SPACE
fnp-5377	97	294	16	16	NUM
fnp-5377	97	295	lateral	lateral	ADJ
fnp-5377	97	296	ventricle	ventricle	NOUN
fnp-5377	97	297	left	leave	VERB
fnp-5377	97	298	glioblastoma	glioblastoma	NOUN
fnp-5377	97	299	loss	loss	NOUN
fnp-5377	97	300	1p	1p	NOUN
fnp-5377	97	301	,	,	PUNCT
fnp-5377	97	302	no	no	DET
fnp-5377	97	303	mutation	mutation	NOUN
fnp-5377	97	304	in	in	ADP
fnp-5377	97	305	exon	exon	PROPN
fnp-5377	97	306	1	1	NUM
fnp-5377	97	307	of	of	ADP
fnp-5377	97	308	the	the	DET
fnp-5377	97	309	h3c2	h3c2	PROPN
fnp-5377	97	310	or	or	CCONJ
fnp-5377	97	311	h3	h3	NOUN
fnp-5377	97	312	-	-	PUNCT
fnp-5377	97	313	3a	3a	NUM
fnp-5377	97	314	genes	gene	NOUN
fnp-5377	97	315	nd	nd	ADP
fnp-5377	97	316	no	no	DET
fnp-5377	97	317	recurrence	recurrence	NOUN
fnp-5377	97	318	at	at	ADP
fnp-5377	97	319	2	2	NUM
fnp-5377	97	320	years	year	NOUN
fnp-5377	97	321	fu	fu	NOUN
fnp-5377	97	322	ibrahim	ibrahim	PROPN
fnp-5377	97	323	et	et	PROPN
fnp-5377	97	324	al	al	PROPN
fnp-5377	97	325	.	.	PROPN
fnp-5377	97	326	201843	201843	NUM
fnp-5377	97	327	21	21	NUM
fnp-5377	97	328	m	m	VERB
fnp-5377	97	329	 	 	SPACE
fnp-5377	97	330	/	/	SYM
fnp-5377	97	331	 	 	SPACE
fnp-5377	97	332	11	11	NUM
fnp-5377	97	333	left	leave	VERB
fnp-5377	97	334	hemisphere	hemisphere	ADV
fnp-5377	97	335	anaplastic	anaplastic	ADJ
fnp-5377	97	336	oligodendroglioma	oligodendroglioma	NOUN
fnp-5377	97	337	nd	nd	INTJ
fnp-5377	97	338	nd	nd	ADV
fnp-5377	97	339	nm	nm	ADV
fnp-5377	97	340	current	current	ADJ
fnp-5377	97	341	case	case	NOUN
fnp-5377	97	342	22	22	NUM
fnp-5377	97	343	f	f	X
fnp-5377	97	344	 	 	SPACE
fnp-5377	97	345	/	/	SYM
fnp-5377	97	346	 	 	SPACE
fnp-5377	97	347	16	16	NUM
fnp-5377	97	348	temporal	temporal	ADJ
fnp-5377	97	349	right	right	ADJ
fnp-5377	97	350	high	high	ADJ
fnp-5377	97	351	grade	grade	NOUN
fnp-5377	97	352	diffuse	diffuse	NOUN
fnp-5377	97	353	glioma	glioma	NOUN
fnp-5377	97	354	l2hgdh	l2hgdh	NOUN
fnp-5377	97	355	,	,	PUNCT
fnp-5377	97	356	tp53	tp53	PROPN
fnp-5377	97	357	,	,	PUNCT
fnp-5377	97	358	nf1	nf1	NOUN
fnp-5377	97	359	,	,	PUNCT
fnp-5377	97	360	bcor	bcor	NOUN
fnp-5377	97	361	diffuse	diffuse	VERB
fnp-5377	97	362	pediatric	pediatric	ADJ
fnp-5377	97	363	-	-	PUNCT
fnp-5377	97	364	type	type	NOUN
fnp-5377	97	365	high	high	ADJ
fnp-5377	97	366	-	-	PUNCT
fnp-5377	97	367	grade	grade	NOUN
fnp-5377	97	368	glioma	glioma	NOUN
fnp-5377	97	369	,	,	PUNCT
fnp-5377	97	370	h3and	h3and	NUM
fnp-5377	97	371	idh	idh	NOUN
fnp-5377	97	372	-	-	PUNCT
fnp-5377	97	373	wildtype	wildtype	NOUN
fnp-5377	97	374	(	(	PUNCT
fnp-5377	97	375	but	but	CCONJ
fnp-5377	97	376	with	with	ADP
fnp-5377	97	377	very	very	ADV
fnp-5377	97	378	low	low	ADJ
fnp-5377	97	379	confidentiality	confidentiality	NOUN
fnp-5377	97	380	score	score	NOUN
fnp-5377	97	381	)	)	PUNCT
fnp-5377	97	382	9	9	NUM
fnp-5377	97	383	months	month	NOUN
fnp-5377	97	384	m	m	VERB
fnp-5377	97	385	:	:	PUNCT
fnp-5377	97	386	male	male	ADJ
fnp-5377	97	387	,	,	PUNCT
fnp-5377	97	388	f	f	X
fnp-5377	97	389	:	:	PUNCT
fnp-5377	97	390	female	female	ADJ
fnp-5377	97	391	,	,	PUNCT
fnp-5377	97	392	nm	nm	NOUN
fnp-5377	97	393	:	:	PUNCT
fnp-5377	97	394	not	not	PART
fnp-5377	97	395	mentioned	mention	VERB
fnp-5377	97	396	,	,	PUNCT
fnp-5377	97	397	nd	nd	PRON
fnp-5377	97	398	:	:	PUNCT
fnp-5377	97	399	not	not	PART
fnp-5377	97	400	determined	determine	VERB
fnp-5377	97	401	,	,	PUNCT
fnp-5377	97	402	pnet	pnet	PROPN
fnp-5377	97	403	:	:	PUNCT
fnp-5377	97	404	primitive	primitive	ADJ
fnp-5377	97	405	neuroectodermal	neuroectodermal	ADJ
fnp-5377	97	406	tumor	tumor	NOUN
fnp-5377	97	407	,	,	PUNCT
fnp-5377	97	408	fu	fu	PROPN
fnp-5377	97	409	:	:	PUNCT
fnp-5377	97	410	follow	follow	VERB
fnp-5377	97	411	-	-	PUNCT
fnp-5377	97	412	up	up	NOUN
fnp-5377	97	413	interestingly	interestingly	ADV
fnp-5377	97	414	,	,	PUNCT
fnp-5377	97	415	idh	idh	NOUN
fnp-5377	97	416	-	-	PUNCT
fnp-5377	97	417	mutant	mutant	NOUN
fnp-5377	97	418	diffuse	diffuse	NOUN
fnp-5377	97	419	gliomas	glioma	NOUN
fnp-5377	97	420	exhibit	exhibit	VERB
fnp-5377	97	421	elevated	elevated	ADJ
fnp-5377	97	422	levels	level	NOUN
fnp-5377	97	423	of	of	ADP
fnp-5377	97	424	d-2	d-2	NOUN
fnp-5377	97	425	-	-	PUNCT
fnp-5377	97	426	hydroxyglutarate	hydroxyglutarate	NOUN
fnp-5377	97	427	(	(	PUNCT
fnp-5377	97	428	d-2	d-2	NOUN
fnp-5377	97	429	-	-	PUNCT
fnp-5377	97	430	hg	hg	NOUN
fnp-5377	97	431	)	)	PUNCT
fnp-5377	97	432	,	,	PUNCT
fnp-5377	97	433	i.e.	i.e.	X
fnp-5377	97	434	the	the	DET
fnp-5377	97	435	enantiomer	enantiomer	NOUN
fnp-5377	97	436	of	of	ADP
fnp-5377	97	437	the	the	DET
fnp-5377	97	438	l-2	l-2	PROPN
fnp-5377	97	439	-	-	PUNCT
fnp-5377	97	440	hg.21	hg.21	PROPN
fnp-5377	97	441	this	this	DET
fnp-5377	97	442	(	(	PUNCT
fnp-5377	97	443	onco	onco	NOUN
fnp-5377	97	444	)	)	PUNCT
fnp-5377	97	445	metabolite	metabolite	NOUN
fnp-5377	97	446	is	be	AUX
fnp-5377	97	447	a	a	DET
fnp-5377	97	448	competitive	competitive	ADJ
fnp-5377	97	449	inhibitor	inhibitor	NOUN
fnp-5377	97	450	of	of	ADP
fnp-5377	97	451	alpha	alpha	PROPN
fnp-5377	97	452	ketoglutarate	ketoglutarate	PROPN
fnp-5377	97	453	-	-	PUNCT
fnp-5377	97	454	dependent	dependent	ADJ
fnp-5377	97	455	dioxygenases	dioxygenase	NOUN
fnp-5377	97	456	,	,	PUNCT
fnp-5377	97	457	including	include	VERB
fnp-5377	97	458	the	the	DET
fnp-5377	97	459	ten	ten	NUM
fnp-5377	97	460	-	-	PUNCT
fnp-5377	97	461	eleven	eleven	NUM
fnp-5377	97	462	translocation	translocation	NOUN
fnp-5377	97	463	(	(	PUNCT
fnp-5377	97	464	tet	tet	NOUN
fnp-5377	97	465	)	)	PUNCT
fnp-5377	97	466	enzymes	enzyme	NOUN
fnp-5377	97	467	which	which	PRON
fnp-5377	97	468	play	play	VERB
fnp-5377	97	469	a	a	DET
fnp-5377	97	470	crucial	crucial	ADJ
fnp-5377	97	471	role	role	NOUN
fnp-5377	97	472	in	in	ADP
fnp-5377	97	473	the	the	DET
fnp-5377	97	474	initial	initial	ADJ
fnp-5377	97	475	stages	stage	NOUN
fnp-5377	97	476	of	of	ADP
fnp-5377	97	477	dna	dna	NOUN
fnp-5377	97	478	demethylation	demethylation	NOUN
fnp-5377	97	479	.	.	PUNCT
fnp-5377	98	1	consequently	consequently	ADV
fnp-5377	98	2	,	,	PUNCT
fnp-5377	98	3	high	high	ADJ
fnp-5377	98	4	levels	level	NOUN
fnp-5377	98	5	of	of	ADP
fnp-5377	98	6	d-2	d-2	NOUN
fnp-5377	98	7	-	-	PUNCT
fnp-5377	98	8	hg	hg	NOUN
fnp-5377	98	9	in	in	ADP
fnp-5377	98	10	idh	idh	NOUN
fnp-5377	98	11	-	-	PUNCT
fnp-5377	98	12	mutated	mutate	VERB
fnp-5377	98	13	tumors	tumor	NOUN
fnp-5377	98	14	lead	lead	VERB
fnp-5377	98	15	to	to	ADP
fnp-5377	98	16	hypermethylation	hypermethylation	NOUN
fnp-5377	98	17	and	and	CCONJ
fnp-5377	98	18	the	the	DET
fnp-5377	98	19	manifestation	manifestation	NOUN
fnp-5377	98	20	of	of	ADP
fnp-5377	98	21	g	g	NOUN
fnp-5377	98	22	-	-	PUNCT
fnp-5377	98	23	cimp	cimp	NOUN
fnp-5377	98	24	.	.	PUNCT
fnp-5377	99	1	notably	notably	ADV
fnp-5377	99	2	,	,	PUNCT
fnp-5377	99	3	d-2	d-2	NOUN
fnp-5377	99	4	-	-	PUNCT
fnp-5377	99	5	hg	hg	NOUN
fnp-5377	99	6	alone	alone	ADV
fnp-5377	99	7	is	be	AUX
fnp-5377	99	8	sufficient	sufficient	ADJ
fnp-5377	99	9	to	to	PART
fnp-5377	99	10	induce	induce	VERB
fnp-5377	99	11	such	such	DET
fnp-5377	99	12	a	a	DET
fnp-5377	99	13	cimp	cimp	NOUN
fnp-5377	99	14	phenotype.9,14	phenotype.9,14	ADP
fnp-5377	99	15	similarly	similarly	ADV
fnp-5377	99	16	,	,	PUNCT
fnp-5377	99	17	l-2	l-2	PROPN
fnp-5377	99	18	-	-	PUNCT
fnp-5377	99	19	hg	hg	PROPN
fnp-5377	99	20	inhibits	inhibit	VERB
fnp-5377	99	21	tet1	tet1	NOUN
fnp-5377	99	22	and	and	CCONJ
fnp-5377	99	23	tet2	tet2	PROPN
fnp-5377	99	24	enzymes,2,11,22	enzymes,2,11,22	PROPN
fnp-5377	99	25	and	and	CCONJ
fnp-5377	99	26	elevated	elevated	ADJ
fnp-5377	99	27	levels	level	NOUN
fnp-5377	99	28	of	of	ADP
fnp-5377	99	29	l-2hg	l-2hg	PROPN
fnp-5377	99	30	were	be	AUX
fnp-5377	99	31	associated	associate	VERB
fnp-5377	99	32	with	with	ADP
fnp-5377	99	33	hypermethylation	hypermethylation	NOUN
fnp-5377	99	34	of	of	ADP
fnp-5377	99	35	dna	dna	NOUN
fnp-5377	99	36	in	in	ADP
fnp-5377	99	37	clear	clear	ADJ
fnp-5377	99	38	cell	cell	NOUN
fnp-5377	99	39	renal	renal	ADJ
fnp-5377	99	40	cell	cell	NOUN
fnp-5377	99	41	carcinoma.23	carcinoma.23	PRON
fnp-5377	99	42	even	even	ADV
fnp-5377	99	43	more	more	ADV
fnp-5377	99	44	,	,	PUNCT
fnp-5377	99	45	it	it	PRON
fnp-5377	99	46	has	have	AUX
fnp-5377	99	47	been	be	AUX
fnp-5377	99	48	shown	show	VERB
fnp-5377	99	49	that	that	SCONJ
fnp-5377	99	50	l-2	l-2	PROPN
fnp-5377	99	51	-	-	PUNCT
fnp-5377	99	52	hg	hg	PROPN
fnp-5377	99	53	was	be	AUX
fnp-5377	99	54	a	a	DET
fnp-5377	99	55	more	more	ADV
fnp-5377	99	56	potent	potent	ADJ
fnp-5377	99	57	inhibitor	inhibitor	NOUN
fnp-5377	99	58	of	of	ADP
fnp-5377	99	59	both	both	DET
fnp-5377	99	60	tet2	tet2	NOUN
fnp-5377	99	61	and	and	CCONJ
fnp-5377	99	62	tet1	tet1	NOUN
fnp-5377	99	63	than	than	ADP
fnp-5377	99	64	d-2	d-2	NOUN
fnp-5377	99	65	-	-	PUNCT
fnp-5377	99	66	hg.24	hg.24	NOUN
fnp-5377	99	67	based	base	VERB
fnp-5377	99	68	on	on	ADP
fnp-5377	99	69	these	these	DET
fnp-5377	99	70	findings	finding	NOUN
fnp-5377	99	71	,	,	PUNCT
fnp-5377	99	72	we	we	PRON
fnp-5377	99	73	hypothesize	hypothesize	VERB
fnp-5377	99	74	that	that	SCONJ
fnp-5377	99	75	individuals	individual	NOUN
fnp-5377	99	76	with	with	ADP
fnp-5377	99	77	l-2	l-2	PROPN
fnp-5377	99	78	-	-	PUNCT
fnp-5377	99	79	hga	hga	PROPN
fnp-5377	99	80	are	be	AUX
fnp-5377	99	81	at	at	ADP
fnp-5377	99	82	risk	risk	NOUN
fnp-5377	99	83	of	of	ADP
fnp-5377	99	84	developing	develop	VERB
fnp-5377	99	85	diffuse	diffuse	ADJ
fnp-5377	99	86	glial	glial	ADJ
fnp-5377	99	87	tumors	tumor	NOUN
fnp-5377	99	88	due	due	ADP
fnp-5377	99	89	to	to	ADP
fnp-5377	99	90	the	the	DET
fnp-5377	99	91	pathological	pathological	ADJ
fnp-5377	99	92	accumulation	accumulation	NOUN
fnp-5377	99	93	of	of	ADP
fnp-5377	99	94	l-2	l-2	PROPN
fnp-5377	99	95	-	-	PUNCT
fnp-5377	99	96	hg	hg	NOUN
fnp-5377	99	97	in	in	ADP
fnp-5377	99	98	the	the	DET
fnp-5377	99	99	brain	brain	NOUN
fnp-5377	99	100	,	,	PUNCT
fnp-5377	99	101	with	with	ADP
fnp-5377	99	102	a	a	DET
fnp-5377	99	103	similar	similar	ADJ
fnp-5377	99	104	g	g	NOUN
fnp-5377	99	105	-	-	PUNCT
fnp-5377	99	106	cimp	cimp	NOUN
fnp-5377	99	107	impact	impact	NOUN
fnp-5377	99	108	on	on	ADP
fnp-5377	99	109	glial	glial	ADJ
fnp-5377	99	110	cells	cell	NOUN
fnp-5377	99	111	and	and	CCONJ
fnp-5377	99	112	maybe	maybe	ADV
fnp-5377	99	113	even	even	ADV
fnp-5377	99	114	clustering	cluster	VERB
fnp-5377	99	115	with	with	ADP
fnp-5377	99	116	the	the	DET
fnp-5377	99	117	idh	idh	NOUN
fnp-5377	99	118	-	-	PUNCT
fnp-5377	99	119	mutant	mutant	NOUN
fnp-5377	99	120	glioma	glioma	NOUN
fnp-5377	99	121	cluster.2,21,25	cluster.2,21,25	VERB
fnp-5377	99	122	however	however	ADV
fnp-5377	99	123	,	,	PUNCT
fnp-5377	99	124	in	in	ADP
fnp-5377	99	125	comparison	comparison	NOUN
fnp-5377	99	126	with	with	ADP
fnp-5377	99	127	the	the	DET
fnp-5377	99	128	methylation	methylation	NOUN
fnp-5377	99	129	array	array	VERB
fnp-5377	99	130	data	datum	NOUN
fnp-5377	99	131	of	of	ADP
fnp-5377	99	132	650	650	NUM
fnp-5377	99	133	adult	adult	NOUN
fnp-5377	99	134	-	-	PUNCT
fnp-5377	99	135	type	type	NOUN
fnp-5377	99	136	diffuse	diffuse	NOUN
fnp-5377	99	137	gliomas	glioma	NOUN
fnp-5377	99	138	of	of	ADP
fnp-5377	99	139	the	the	DET
fnp-5377	99	140	catnon	catnon	NOUN
fnp-5377	99	141	database	database	NOUN
fnp-5377	99	142	,	,	PUNCT
fnp-5377	99	143	the	the	DET
fnp-5377	99	144	tumor	tumor	NOUN
fnp-5377	99	145	of	of	ADP
fnp-5377	99	146	our	our	PRON
fnp-5377	99	147	patient	patient	NOUN
fnp-5377	99	148	showed	show	VERB
fnp-5377	99	149	relatively	relatively	ADV
fnp-5377	99	150	low	low	ADJ
fnp-5377	99	151	mean	mean	ADJ
fnp-5377	99	152	dna	dna	PROPN
fnp-5377	99	153	methylation	methylation	NOUN
fnp-5377	99	154	levels	level	NOUN
fnp-5377	99	155	at	at	ADP
fnp-5377	99	156	cpg	cpg	NOUN
fnp-5377	99	157	sites	site	NOUN
fnp-5377	99	158	,	,	PUNCT
fnp-5377	99	159	and	and	CCONJ
fnp-5377	99	160	(	(	PUNCT
fnp-5377	99	161	in	in	ADP
fnp-5377	99	162	line	line	NOUN
fnp-5377	99	163	with	with	ADP
fnp-5377	99	164	most	most	ADJ
fnp-5377	99	165	methylation	methylation	NOUN
fnp-5377	99	166	classifier	classifier	NOUN
fnp-5377	99	167	and	and	CCONJ
fnp-5377	99	168	wes	wes	PROPN
fnp-5377	99	169	results	result	NOUN
fnp-5377	99	170	)	)	PUNCT
fnp-5377	99	171	clustered	cluster	VERB
fnp-5377	99	172	with	with	ADP
fnp-5377	99	173	idh	idh	NOUN
fnp-5377	99	174	-	-	PUNCT
fnp-5377	99	175	wildtype	wildtype	NOUN
fnp-5377	99	176	samples	sample	NOUN
fnp-5377	99	177	.	.	PUNCT
fnp-5377	100	1	this	this	DET
fnp-5377	100	2	unexpected	unexpected	ADJ
fnp-5377	100	3	observation	observation	NOUN
fnp-5377	100	4	illustrates	illustrate	VERB
fnp-5377	100	5	the	the	DET
fnp-5377	100	6	complexity	complexity	NOUN
fnp-5377	100	7	of	of	ADP
fnp-5377	100	8	elevated	elevated	ADJ
fnp-5377	100	9	levels	level	NOUN
fnp-5377	100	10	of	of	ADP
fnp-5377	100	11	d-2	d-2	NOUN
fnp-5377	100	12	-	-	PUNCT
fnp-5377	100	13	hg	hg	NOUN
fnp-5377	100	14	versus	versus	ADP
fnp-5377	100	15	l-2	l-2	PROPN
fnp-5377	100	16	-	-	PUNCT
fnp-5377	100	17	hg	hg	NOUN
fnp-5377	100	18	in	in	ADP
fnp-5377	100	19	oncogenesis	oncogenesis	NOUN
fnp-5377	100	20	.	.	PUNCT
fnp-5377	101	1	one	one	NUM
fnp-5377	101	2	possible	possible	ADJ
fnp-5377	101	3	explanation	explanation	NOUN
fnp-5377	101	4	is	be	AUX
fnp-5377	101	5	that	that	SCONJ
fnp-5377	101	6	the	the	DET
fnp-5377	101	7	mechanism	mechanism	NOUN
fnp-5377	101	8	underlying	underlie	VERB
fnp-5377	101	9	elevated	elevated	ADJ
fnp-5377	101	10	levels	level	NOUN
fnp-5377	101	11	of	of	ADP
fnp-5377	101	12	2hg	2hg	ADJ
fnp-5377	101	13	differs	differ	NOUN
fnp-5377	101	14	between	between	ADP
fnp-5377	101	15	l2hgdhor	l2hgdhor	NOUN
fnp-5377	101	16	l2hgdh	l2hgdh	ADV
fnp-5377	101	17	-	-	PUNCT
fnp-5377	101	18	associated	associate	VERB
fnp-5377	101	19	disease	disease	NOUN
fnp-5377	101	20	compared	compare	VERB
fnp-5377	101	21	to	to	ADP
fnp-5377	101	22	idh	idh	NOUN
fnp-5377	101	23	-	-	PUNCT
fnp-5377	101	24	mutant	mutant	ADJ
fnp-5377	101	25	tumors	tumor	NOUN
fnp-5377	101	26	.	.	PUNCT
fnp-5377	102	1	mutations	mutation	NOUN
fnp-5377	102	2	in	in	ADP
fnp-5377	102	3	l2hgdh	l2hgdh	ADJ
fnp-5377	102	4	or	or	CCONJ
fnp-5377	102	5	d2hgdh	d2hgdh	NOUN
fnp-5377	102	6	lead	lead	NOUN
fnp-5377	102	7	to	to	ADP
fnp-5377	102	8	a	a	DET
fnp-5377	102	9	generalized	generalize	VERB
fnp-5377	102	10	passive	passive	ADJ
fnp-5377	102	11	accumulation	accumulation	NOUN
fnp-5377	102	12	of	of	ADP
fnp-5377	102	13	2hg	2hg	ADJ
fnp-5377	102	14	throughout	throughout	ADP
fnp-5377	102	15	the	the	DET
fnp-5377	102	16	body	body	NOUN
fnp-5377	102	17	,	,	PUNCT
fnp-5377	102	18	whereas	whereas	SCONJ
fnp-5377	102	19	mutations	mutation	NOUN
fnp-5377	102	20	in	in	ADP
fnp-5377	102	21	idh	idh	NOUN
fnp-5377	102	22	genes	gene	NOUN
fnp-5377	102	23	in	in	ADP
fnp-5377	102	24	tumors	tumor	NOUN
fnp-5377	102	25	result	result	VERB
fnp-5377	102	26	in	in	ADP
fnp-5377	102	27	high	high	ADJ
fnp-5377	102	28	levels	level	NOUN
fnp-5377	102	29	of	of	ADP
fnp-5377	102	30	2hg	2hg	ADJ
fnp-5377	102	31	within	within	ADP
fnp-5377	102	32	the	the	DET
fnp-5377	102	33	tumor	tumor	NOUN
fnp-5377	102	34	cells	cell	NOUN
fnp-5377	102	35	themselves	themselves	PRON
fnp-5377	102	36	with	with	ADP
fnp-5377	102	37	therefore	therefore	ADV
fnp-5377	102	38	possibly	possibly	ADV
fnp-5377	102	39	stronger	strong	ADJ
fnp-5377	102	40	local	local	ADJ
fnp-5377	102	41	effect	effect	NOUN
fnp-5377	102	42	on	on	ADP
fnp-5377	102	43	tet	tet	NOUN
fnp-5377	102	44	-	-	PUNCT
fnp-5377	102	45	enzyme	enzyme	NOUN
fnp-5377	102	46	activity	activity	NOUN
fnp-5377	102	47	and	and	CCONJ
fnp-5377	102	48	subsequent	subsequent	ADJ
fnp-5377	102	49	hypermethylation.26,27	hypermethylation.26,27	NOUN
fnp-5377	102	50	of	of	ADP
fnp-5377	102	51	note	note	NOUN
fnp-5377	102	52	,	,	PUNCT
fnp-5377	102	53	elevated	elevated	ADJ
fnp-5377	102	54	d-2	d-2	NOUN
fnp-5377	102	55	-	-	PUNCT
fnp-5377	102	56	hg	hg	NOUN
fnp-5377	102	57	levels	level	NOUN
fnp-5377	102	58	can	can	AUX
fnp-5377	102	59	also	also	ADV
fnp-5377	102	60	occur	occur	VERB
fnp-5377	102	61	in	in	ADP
fnp-5377	102	62	the	the	DET
fnp-5377	102	63	context	context	NOUN
fnp-5377	102	64	of	of	ADP
fnp-5377	102	65	neurometabolic	neurometabolic	ADJ
fnp-5377	102	66	disorders	disorder	NOUN
fnp-5377	102	67	d-2	d-2	NOUN
fnp-5377	102	68	-	-	PUNCT
fnp-5377	102	69	hga	hga	NOUN
fnp-5377	102	70	type	type	NOUN
fnp-5377	102	71	1	1	NUM
fnp-5377	102	72	(	(	PUNCT
fnp-5377	102	73	due	due	ADP
fnp-5377	102	74	to	to	ADP
fnp-5377	102	75	a	a	DET
fnp-5377	102	76	mutation	mutation	NOUN
fnp-5377	102	77	in	in	ADP
fnp-5377	102	78	the	the	DET
fnp-5377	102	79	d2hgdh	d2hgdh	NOUN
fnp-5377	102	80	gene	gene	NOUN
fnp-5377	102	81	)	)	PUNCT
fnp-5377	102	82	and	and	CCONJ
fnp-5377	102	83	type	type	NOUN
fnp-5377	102	84	2	2	NUM
fnp-5377	102	85	(	(	PUNCT
fnp-5377	102	86	due	due	ADP
fnp-5377	102	87	to	to	ADP
fnp-5377	102	88	heterozygous	heterozygous	ADJ
fnp-5377	102	89	mutation	mutation	NOUN
fnp-5377	102	90	in	in	ADP
fnp-5377	102	91	idh2	idh2	PROPN
fnp-5377	102	92	)	)	PUNCT
fnp-5377	102	93	.	.	PUNCT
fnp-5377	103	1	in	in	ADP
fnp-5377	103	2	that	that	DET
fnp-5377	103	3	context	context	NOUN
fnp-5377	103	4	,	,	PUNCT
fnp-5377	103	5	increased	increase	VERB
fnp-5377	103	6	d-2	d-2	NOUN
fnp-5377	103	7	-	-	PUNCT
fnp-5377	103	8	hg	hg	NOUN
fnp-5377	103	9	levels	level	NOUN
fnp-5377	103	10	do	do	AUX
fnp-5377	103	11	not	not	PART
fnp-5377	103	12	lead	lead	VERB
fnp-5377	103	13	to	to	ADP
fnp-5377	103	14	gliomas.28	gliomas.28	PROPN
fnp-5377	103	15	this	this	PRON
fnp-5377	103	16	can	can	AUX
fnp-5377	103	17	be	be	AUX
fnp-5377	103	18	partly	partly	ADV
fnp-5377	103	19	attributed	attribute	VERB
fnp-5377	103	20	to	to	ADP
fnp-5377	103	21	discrepancies	discrepancy	NOUN
fnp-5377	103	22	in	in	ADP
fnp-5377	103	23	life	life	NOUN
fnp-5377	103	24	expectancy	expectancy	NOUN
fnp-5377	103	25	,	,	PUNCT
fnp-5377	103	26	as	as	SCONJ
fnp-5377	103	27	patients	patient	NOUN
fnp-5377	103	28	with	with	ADP
fnp-5377	103	29	type	type	NOUN
fnp-5377	103	30	2	2	NUM
fnp-5377	103	31	d-2	d-2	NOUN
fnp-5377	103	32	-	-	PUNCT
fnp-5377	103	33	hga	hga	NOUN
fnp-5377	103	34	,	,	PUNCT
fnp-5377	103	35	based	base	VERB
fnp-5377	103	36	on	on	ADP
fnp-5377	103	37	an	an	DET
fnp-5377	103	38	idh2	idh2	PROPN
fnp-5377	103	39	mutation	mutation	NOUN
fnp-5377	103	40	,	,	PUNCT
fnp-5377	103	41	exhibit	exhibit	VERB
fnp-5377	103	42	similarly	similarly	ADV
fnp-5377	103	43	elevated	elevate	VERB
fnp-5377	103	44	d-2	d-2	NOUN
fnp-5377	103	45	-	-	PUNCT
fnp-5377	103	46	hg	hg	NOUN
fnp-5377	103	47	levels	level	NOUN
fnp-5377	103	48	but	but	CCONJ
fnp-5377	103	49	have	have	VERB
fnp-5377	103	50	such	such	DET
fnp-5377	103	51	a	a	DET
fnp-5377	103	52	severe	severe	ADJ
fnp-5377	103	53	clinical	clinical	ADJ
fnp-5377	103	54	course	course	NOUN
fnp-5377	103	55	that	that	SCONJ
fnp-5377	103	56	they	they	PRON
fnp-5377	103	57	may	may	AUX
fnp-5377	103	58	not	not	PART
fnp-5377	103	59	survive	survive	VERB
fnp-5377	103	60	long	long	ADV
fnp-5377	103	61	enough	enough	ADV
fnp-5377	103	62	for	for	ADP
fnp-5377	103	63	glioma	glioma	NOUN
fnp-5377	103	64	development.29,30,31	development.29,30,31	ADV
fnp-5377	103	65	another	another	DET
fnp-5377	103	66	explanation	explanation	NOUN
fnp-5377	103	67	can	can	AUX
fnp-5377	103	68	be	be	AUX
fnp-5377	103	69	sought	seek	VERB
fnp-5377	103	70	in	in	ADP
fnp-5377	103	71	stereoisomerism	stereoisomerism	NOUN
fnp-5377	103	72	.	.	PUNCT
fnp-5377	104	1	even	even	ADV
fnp-5377	104	2	though	though	SCONJ
fnp-5377	104	3	l-2	l-2	PROPN
fnp-5377	104	4	-	-	PUNCT
fnp-5377	104	5	hg	hg	PROPN
fnp-5377	104	6	and	and	CCONJ
fnp-5377	104	7	d-2	d-2	NOUN
fnp-5377	104	8	-	-	PUNCT
fnp-5377	104	9	hg	hg	NOUN
fnp-5377	104	10	are	be	AUX
fnp-5377	104	11	structurally	structurally	ADV
fnp-5377	104	12	similar	similar	ADJ
fnp-5377	104	13	molecules	molecule	NOUN
fnp-5377	104	14	,	,	PUNCT
fnp-5377	104	15	studies	study	NOUN
fnp-5377	104	16	have	have	AUX
fnp-5377	104	17	suggested	suggest	VERB
fnp-5377	104	18	that	that	SCONJ
fnp-5377	104	19	l-2	l-2	PROPN
fnp-5377	104	20	-	-	PUNCT
fnp-5377	104	21	hg	hg	PROPN
fnp-5377	104	22	and	and	CCONJ
fnp-5377	104	23	d-2	d-2	NOUN
fnp-5377	104	24	-	-	PUNCT
fnp-5377	104	25	hg	hg	NOUN
fnp-5377	104	26	may	may	AUX
fnp-5377	104	27	have	have	VERB
fnp-5377	104	28	differential	differential	VERB
fnp-5377	104	29	inhibitory	inhibitory	ADJ
fnp-5377	104	30	effects	effect	NOUN
fnp-5377	104	31	on	on	ADP
fnp-5377	104	32	certain	certain	ADJ
fnp-5377	104	33	enzymes	enzyme	NOUN
fnp-5377	104	34	,	,	PUNCT
fnp-5377	104	35	conceivably	conceivably	ADV
fnp-5377	104	36	due	due	ADP
fnp-5377	104	37	to	to	ADP
fnp-5377	104	38	variations	variation	NOUN
fnp-5377	104	39	in	in	ADP
fnp-5377	104	40	the	the	DET
fnp-5377	104	41	stereochemistry	stereochemistry	NOUN
fnp-5377	104	42	of	of	ADP
fnp-5377	104	43	l-2	l-2	PROPN
fnp-5377	104	44	-	-	PUNCT
fnp-5377	104	45	hg	hg	PROPN
fnp-5377	104	46	and	and	CCONJ
fnp-5377	104	47	d-2	d-2	NOUN
fnp-5377	104	48	-	-	PUNCT
fnp-5377	104	49	hg	hg	NOUN
fnp-5377	104	50	molecules	molecule	NOUN
fnp-5377	104	51	.	.	PUNCT
fnp-5377	105	1	overall	overall	ADJ
fnp-5377	105	2	,	,	PUNCT
fnp-5377	105	3	while	while	SCONJ
fnp-5377	105	4	both	both	PRON
fnp-5377	105	5	l-2	l-2	PROPN
fnp-5377	105	6	-	-	PUNCT
fnp-5377	105	7	hg	hg	NOUN
fnp-5377	105	8	and	and	CCONJ
fnp-5377	105	9	d-2	d-2	NOUN
fnp-5377	105	10	-	-	PUNCT
fnp-5377	105	11	hg	hg	NOUN
fnp-5377	105	12	function	function	NOUN
fnp-5377	105	13	as	as	ADP
fnp-5377	105	14	inhibitors	inhibitor	NOUN
fnp-5377	105	15	in	in	ADP
fnp-5377	105	16	cellular	cellular	ADJ
fnp-5377	105	17	metabolism	metabolism	NOUN
fnp-5377	105	18	,	,	PUNCT
fnp-5377	105	19	their	their	PRON
fnp-5377	105	20	specific	specific	ADJ
fnp-5377	105	21	effects	effect	NOUN
fnp-5377	105	22	and	and	CCONJ
fnp-5377	105	23	potency	potency	NOUN
fnp-5377	105	24	may	may	AUX
fnp-5377	105	25	vary	vary	VERB
fnp-5377	105	26	depending	depend	VERB
fnp-5377	105	27	on	on	ADP
fnp-5377	105	28	the	the	DET
fnp-5377	105	29	context	context	NOUN
fnp-5377	105	30	and	and	CCONJ
fnp-5377	105	31	the	the	DET
fnp-5377	105	32	particular	particular	ADJ
fnp-5377	105	33	enzymes	enzyme	NOUN
fnp-5377	105	34	or	or	CCONJ
fnp-5377	105	35	pathways	pathway	NOUN
fnp-5377	105	36	involved	involve	VERB
fnp-5377	105	37	.	.	PUNCT
fnp-5377	106	1	this	this	PRON
fnp-5377	106	2	is	be	AUX
fnp-5377	106	3	further	far	ADV
fnp-5377	106	4	stressed	stress	VERB
fnp-5377	106	5	by	by	ADP
fnp-5377	106	6	the	the	DET
fnp-5377	106	7	observation	observation	NOUN
fnp-5377	106	8	that	that	SCONJ
fnp-5377	106	9	the	the	DET
fnp-5377	106	10	level	level	NOUN
fnp-5377	106	11	of	of	ADP
fnp-5377	106	12	l-2	l-2	PROPN
fnp-5377	106	13	-	-	PUNCT
fnp-5377	106	14	hg	hg	PROPN
fnp-5377	106	15	does	do	AUX
fnp-5377	106	16	not	not	PART
fnp-5377	106	17	per	per	ADV
fnp-5377	106	18	se	se	X
fnp-5377	106	19	correlate	correlate	VERB
fnp-5377	106	20	with	with	ADP
fnp-5377	106	21	risk	risk	NOUN
fnp-5377	106	22	of	of	ADP
fnp-5377	106	23	cns	cns	PROPN
fnp-5377	106	24	tumor	tumor	NOUN
fnp-5377	106	25	development.32	development.32	VERB
fnp-5377	106	26	therefore	therefore	ADV
fnp-5377	106	27	it	it	PRON
fnp-5377	106	28	seems	seem	VERB
fnp-5377	106	29	that	that	SCONJ
fnp-5377	106	30	2	2	NUM
fnp-5377	106	31	-	-	PUNCT
fnp-5377	106	32	hg	hg	NOUN
fnp-5377	106	33	has	have	VERB
fnp-5377	106	34	physiological	physiological	ADJ
fnp-5377	106	35	roles	role	NOUN
fnp-5377	106	36	that	that	PRON
fnp-5377	106	37	extend	extend	VERB
fnp-5377	106	38	beyond	beyond	ADP
fnp-5377	106	39	being	be	AUX
fnp-5377	106	40	an	an	DET
fnp-5377	106	41	oncometabolite	oncometabolite	NOUN
fnp-5377	106	42	by	by	ADP
fnp-5377	106	43	itself	itself	PRON
fnp-5377	106	44	.	.	PUNCT
fnp-5377	107	1	notably	notably	ADV
fnp-5377	107	2	,	,	PUNCT
fnp-5377	107	3	there	there	PRON
fnp-5377	107	4	appears	appear	VERB
fnp-5377	107	5	to	to	PART
fnp-5377	107	6	be	be	AUX
fnp-5377	107	7	no	no	DET
fnp-5377	107	8	sex	sex	NOUN
fnp-5377	107	9	predisposition	predisposition	NOUN
fnp-5377	107	10	to	to	ADP
fnp-5377	107	11	the	the	DET
fnp-5377	107	12	carcinogenic	carcinogenic	ADJ
fnp-5377	107	13	effect.2	effect.2	PROPN
fnp-5377	107	14	also	also	ADV
fnp-5377	107	15	,	,	PUNCT
fnp-5377	107	16	so	so	ADV
fnp-5377	107	17	far	far	ADV
fnp-5377	107	18	,	,	PUNCT
fnp-5377	107	19	evidence	evidence	NOUN
fnp-5377	107	20	for	for	ADP
fnp-5377	107	21	a	a	DET
fnp-5377	107	22	common	common	ADJ
fnp-5377	107	23	molecular	molecular	ADJ
fnp-5377	107	24	mechanism	mechanism	NOUN
fnp-5377	107	25	downstream	downstream	NOUN
fnp-5377	107	26	of	of	ADP
fnp-5377	107	27	the	the	DET
fnp-5377	107	28	l2hgdh	l2hgdh	ADJ
fnp-5377	107	29	mutation	mutation	NOUN
fnp-5377	107	30	is	be	AUX
fnp-5377	107	31	lacking	lack	VERB
fnp-5377	107	32	.	.	PUNCT
fnp-5377	108	1	patay	patay	NOUN
fnp-5377	108	2	et	et	PROPN
fnp-5377	108	3	al	al	PROPN
fnp-5377	108	4	.	.	PROPN
fnp-5377	109	1	(	(	PUNCT
fnp-5377	109	2	2015	2015	NUM
fnp-5377	109	3	)	)	PUNCT
fnp-5377	109	4	identified	identify	VERB
fnp-5377	109	5	an	an	DET
fnp-5377	109	6	egfr	egfr	ADJ
fnp-5377	109	7	amplification	amplification	NOUN
fnp-5377	109	8	in	in	ADP
fnp-5377	109	9	their	their	PRON
fnp-5377	109	10	case	case	NOUN
fnp-5377	109	11	of	of	ADP
fnp-5377	109	12	anaplastic	anaplastic	ADJ
fnp-5377	109	13	astrocytoma	astrocytoma	NOUN
fnp-5377	109	14	(	(	PUNCT
fnp-5377	109	15	table	table	NOUN
fnp-5377	109	16	1	1	NUM
fnp-5377	109	17	,	,	PUNCT
fnp-5377	109	18	case	case	NOUN
fnp-5377	109	19	19	19	NUM
fnp-5377	109	20	)	)	PUNCT
fnp-5377	109	21	which	which	PRON
fnp-5377	109	22	lacked	lack	VERB
fnp-5377	109	23	an	an	DET
fnp-5377	109	24	idh	idh	NOUN
fnp-5377	109	25	mutation	mutation	NOUN
fnp-5377	109	26	.	.	PUNCT
fnp-5377	110	1	they	they	PRON
fnp-5377	110	2	therefore	therefore	ADV
fnp-5377	110	3	proposed	propose	VERB
fnp-5377	110	4	a	a	DET
fnp-5377	110	5	potential	potential	ADJ
fnp-5377	110	6	connection	connection	NOUN
fnp-5377	110	7	between	between	ADP
fnp-5377	110	8	astrocytic	astrocytic	ADJ
fnp-5377	110	9	tumors	tumor	NOUN
fnp-5377	110	10	and	and	CCONJ
fnp-5377	110	11	egfr	egfr	ADJ
fnp-5377	110	12	alterations	alteration	NOUN
fnp-5377	110	13	as	as	ADP
fnp-5377	110	14	potential	potential	ADJ
fnp-5377	110	15	oncogenic	oncogenic	ADJ
fnp-5377	110	16	driver	driver	NOUN
fnp-5377	110	17	mechanism	mechanism	NOUN
fnp-5377	110	18	in	in	ADP
fnp-5377	110	19	l-2	l-2	PROPN
fnp-5377	110	20	-	-	PUNCT
fnp-5377	110	21	hg	hg	NOUN
fnp-5377	110	22	-	-	ADJ
fnp-5377	110	23	induced	induced	ADJ
fnp-5377	110	24	tumorigenesis.21	tumorigenesis.21	NOUN
fnp-5377	110	25	however	however	ADV
fnp-5377	110	26	,	,	PUNCT
fnp-5377	110	27	in	in	ADP
fnp-5377	110	28	our	our	PRON
fnp-5377	110	29	case	case	NOUN
fnp-5377	110	30	,	,	PUNCT
fnp-5377	110	31	and	and	CCONJ
fnp-5377	110	32	in	in	ADP
fnp-5377	110	33	all	all	DET
fnp-5377	110	34	other	other	ADJ
fnp-5377	110	35	cases	case	NOUN
fnp-5377	110	36	presented	present	VERB
fnp-5377	110	37	in	in	ADP
fnp-5377	110	38	the	the	DET
fnp-5377	110	39	literature	literature	NOUN
fnp-5377	110	40	,	,	PUNCT
fnp-5377	110	41	no	no	DET
fnp-5377	110	42	egfr	egfr	ADJ
fnp-5377	110	43	alterations	alteration	NOUN
fnp-5377	110	44	were	be	AUX
fnp-5377	110	45	reported	report	VERB
fnp-5377	110	46	.	.	PUNCT
fnp-5377	111	1	possibly	possibly	ADV
fnp-5377	111	2	,	,	PUNCT
fnp-5377	111	3	the	the	DET
fnp-5377	111	4	oncogenesis	oncogenesis	NOUN
fnp-5377	111	5	in	in	ADP
fnp-5377	111	6	l-2	l-2	PROPN
fnp-5377	111	7	-	-	PUNCT
fnp-5377	111	8	hga	hga	PROPN
fnp-5377	111	9	is	be	AUX
fnp-5377	111	10	like	like	ADP
fnp-5377	111	11	a	a	DET
fnp-5377	111	12	two	two	NUM
fnp-5377	111	13	-	-	PUNCT
fnp-5377	111	14	tiered	tiere	VERB
fnp-5377	111	15	oncogenesis	oncogenesis	NOUN
fnp-5377	111	16	system	system	NOUN
fnp-5377	111	17	in	in	ADP
fnp-5377	111	18	which	which	PRON
fnp-5377	111	19	accumulated	accumulate	VERB
fnp-5377	111	20	levels	level	NOUN
fnp-5377	111	21	of	of	ADP
fnp-5377	111	22	l-2	l-2	PROPN
fnp-5377	111	23	-	-	PUNCT
fnp-5377	111	24	hg	hg	PROPN
fnp-5377	111	25	form	form	NOUN
fnp-5377	111	26	the	the	DET
fnp-5377	111	27	first	first	ADJ
fnp-5377	111	28	hit	hit	NOUN
fnp-5377	111	29	,	,	PUNCT
fnp-5377	111	30	and	and	CCONJ
fnp-5377	111	31	a	a	DET
fnp-5377	111	32	mutation	mutation	NOUN
fnp-5377	111	33	(	(	PUNCT
fnp-5377	111	34	which	which	PRON
fnp-5377	111	35	may	may	AUX
fnp-5377	111	36	arise	arise	VERB
fnp-5377	111	37	in	in	ADP
fnp-5377	111	38	different	different	ADJ
fnp-5377	111	39	pathways	pathway	NOUN
fnp-5377	111	40	)	)	PUNCT
fnp-5377	111	41	forms	form	VERB
fnp-5377	111	42	the	the	DET
fnp-5377	111	43	second	second	ADJ
fnp-5377	111	44	hit	hit	NOUN
fnp-5377	111	45	eventually	eventually	ADV
fnp-5377	111	46	leading	lead	VERB
fnp-5377	111	47	to	to	ADP
fnp-5377	111	48	tumor	tumor	NOUN
fnp-5377	111	49	formation	formation	NOUN
fnp-5377	111	50	,	,	PUNCT
fnp-5377	111	51	with	with	ADP
fnp-5377	111	52	a	a	DET
fnp-5377	111	53	different	different	ADJ
fnp-5377	111	54	pathophysiology	pathophysiology	NOUN
fnp-5377	111	55	than	than	ADP
fnp-5377	111	56	in	in	ADP
fnp-5377	111	57	the	the	DET
fnp-5377	111	58	idh	idh	NOUN
fnp-5377	111	59	-	-	PUNCT
fnp-5377	111	60	mutant	mutant	NOUN
fnp-5377	111	61	tumor	tumor	NOUN
fnp-5377	111	62	.	.	PUNCT
fnp-5377	112	1	besides	besides	SCONJ
fnp-5377	112	2	the	the	DET
fnp-5377	112	3	l2hgdh	l2hgdh	ADJ
fnp-5377	112	4	mutation	mutation	NOUN
fnp-5377	112	5	,	,	PUNCT
fnp-5377	112	6	the	the	DET
fnp-5377	112	7	tumor	tumor	NOUN
fnp-5377	112	8	analyzed	analyze	VERB
fnp-5377	112	9	in	in	ADP
fnp-5377	112	10	this	this	DET
fnp-5377	112	11	report	report	NOUN
fnp-5377	112	12	also	also	ADV
fnp-5377	112	13	contained	contain	VERB
fnp-5377	112	14	tp53	tp53	PROPN
fnp-5377	112	15	,	,	PUNCT
fnp-5377	112	16	bcor	bcor	NOUN
fnp-5377	112	17	and	and	CCONJ
fnp-5377	112	18	nf1	nf1	NOUN
fnp-5377	112	19	mutations	mutation	NOUN
fnp-5377	112	20	,	,	PUNCT
fnp-5377	112	21	as	as	ADV
fnp-5377	112	22	well	well	ADV
fnp-5377	112	23	as	as	ADP
fnp-5377	112	24	numerous	numerous	ADJ
fnp-5377	112	25	copy	copy	NOUN
fnp-5377	112	26	number	number	NOUN
fnp-5377	112	27	changes	change	NOUN
fnp-5377	112	28	.	.	PUNCT
fnp-5377	113	1	it	it	PRON
fnp-5377	113	2	is	be	AUX
fnp-5377	113	3	known	know	VERB
fnp-5377	113	4	that	that	SCONJ
fnp-5377	113	5	malignant	malignant	ADJ
fnp-5377	113	6	progression	progression	NOUN
fnp-5377	113	7	of	of	ADP
fnp-5377	113	8	idh	idh	NOUN
fnp-5377	113	9	-	-	PUNCT
fnp-5377	113	10	mutant	mutant	NOUN
fnp-5377	113	11	astrocytomas	astrocytoma	NOUN
fnp-5377	113	12	is	be	AUX
fnp-5377	113	13	associated	associate	VERB
fnp-5377	113	14	with	with	ADP
fnp-5377	113	15	relative	relative	ADJ
fnp-5377	113	16	hypomethylation	hypomethylation	NOUN
fnp-5377	113	17	(	(	PUNCT
fnp-5377	113	18	reduced	reduce	VERB
fnp-5377	113	19	g	g	NOUN
fnp-5377	113	20	-	-	PUNCT
fnp-5377	113	21	cimp	cimp	NOUN
fnp-5377	113	22	status	status	NOUN
fnp-5377	113	23	)	)	PUNCT
fnp-5377	113	24	,	,	PUNCT
fnp-5377	113	25	a	a	DET
fnp-5377	113	26	phenomenon	phenomenon	NOUN
fnp-5377	113	27	which	which	PRON
fnp-5377	113	28	may	may	AUX
fnp-5377	113	29	be	be	AUX
fnp-5377	113	30	associated	associate	VERB
fnp-5377	113	31	with	with	ADP
fnp-5377	113	32	(	(	PUNCT
fnp-5377	113	33	homozygous	homozygous	ADJ
fnp-5377	113	34	)	)	PUNCT
fnp-5377	113	35	cdkn2a	cdkn2a	PROPN
fnp-5377	113	36	/	/	SYM
fnp-5377	113	37	b	b	NOUN
fnp-5377	113	38	loss	loss	NOUN
fnp-5377	113	39	or	or	CCONJ
fnp-5377	113	40	other	other	ADJ
fnp-5377	113	41	cell	cell	NOUN
fnp-5377	113	42	cycle	cycle	NOUN
fnp-5377	113	43	gene	gene	NOUN
fnp-5377	113	44	alterations	alteration	NOUN
fnp-5377	113	45	in	in	ADP
fnp-5377	113	46	these	these	DET
fnp-5377	113	47	tumors.33,34	tumors.33,34	NOUN
fnp-5377	113	48	however	however	ADV
fnp-5377	113	49	,	,	PUNCT
fnp-5377	113	50	in	in	ADP
fnp-5377	113	51	the	the	DET
fnp-5377	113	52	tumor	tumor	NOUN
fnp-5377	113	53	of	of	ADP
fnp-5377	113	54	our	our	PRON
fnp-5377	113	55	l-2	l-2	PROPN
fnp-5377	113	56	-	-	PUNCT
fnp-5377	113	57	hga	hga	PROPN
fnp-5377	113	58	patient	patient	ADJ
fnp-5377	113	59	homozygous	homozygous	ADJ
fnp-5377	113	60	loss	loss	NOUN
fnp-5377	113	61	of	of	ADP
fnp-5377	113	62	cdkn2a	cdkn2a	PROPN
fnp-5377	113	63	/	/	SYM
fnp-5377	113	64	b	b	PROPN
fnp-5377	113	65	was	be	AUX
fnp-5377	113	66	absent	absent	ADJ
fnp-5377	113	67	.	.	PUNCT
fnp-5377	114	1	we	we	PRON
fnp-5377	114	2	speculate	speculate	VERB
fnp-5377	114	3	that	that	SCONJ
fnp-5377	114	4	in	in	ADP
fnp-5377	114	5	our	our	PRON
fnp-5377	114	6	case	case	NOUN
fnp-5377	114	7	other	other	ADJ
fnp-5377	114	8	molecular	molecular	ADJ
fnp-5377	114	9	alterations	alteration	NOUN
fnp-5377	114	10	had	have	VERB
fnp-5377	114	11	an	an	DET
fnp-5377	114	12	impact	impact	NOUN
fnp-5377	114	13	on	on	ADP
fnp-5377	114	14	l-2	l-2	PROPN
fnp-5377	114	15	-	-	PUNCT
fnp-5377	114	16	hg	hg	NOUN
fnp-5377	114	17	levels	level	NOUN
fnp-5377	114	18	,	,	PUNCT
fnp-5377	114	19	tet	tet	NOUN
fnp-5377	114	20	-	-	NOUN
fnp-5377	114	21	enzymes	enzyme	NOUN
fnp-5377	114	22	or	or	CCONJ
fnp-5377	114	23	other	other	ADJ
fnp-5377	114	24	epigenetic	epigenetic	ADJ
fnp-5377	114	25	mechanisms	mechanism	NOUN
fnp-5377	114	26	resulting	result	VERB
fnp-5377	114	27	in	in	ADP
fnp-5377	114	28	absence	absence	NOUN
fnp-5377	114	29	of	of	ADP
fnp-5377	114	30	g	g	NOUN
fnp-5377	114	31	-	-	PUNCT
fnp-5377	114	32	cimp	cimp	NOUN
fnp-5377	114	33	.	.	PUNCT
fnp-5377	115	1	unfortunately	unfortunately	ADV
fnp-5377	115	2	,	,	PUNCT
fnp-5377	115	3	no	no	DET
fnp-5377	115	4	tumor	tumor	NOUN
fnp-5377	115	5	tissue	tissue	NOUN
fnp-5377	115	6	was	be	AUX
fnp-5377	115	7	left	leave	VERB
fnp-5377	115	8	for	for	ADP
fnp-5377	115	9	proper	proper	ADJ
fnp-5377	115	10	assessment	assessment	NOUN
fnp-5377	115	11	of	of	ADP
fnp-5377	115	12	l-2	l-2	PROPN
fnp-5377	115	13	-	-	PUNCT
fnp-5377	115	14	hg	hg	NOUN
fnp-5377	115	15	at	at	ADP
fnp-5377	115	16	the	the	DET
fnp-5377	115	17	protein	protein	NOUN
fnp-5377	115	18	level	level	NOUN
fnp-5377	115	19	.	.	PUNCT
fnp-5377	116	1	taken	take	VERB
fnp-5377	116	2	together	together	ADV
fnp-5377	116	3	,	,	PUNCT
fnp-5377	116	4	our	our	PRON
fnp-5377	116	5	findings	finding	NOUN
fnp-5377	116	6	shed	shed	VERB
fnp-5377	116	7	unprecedented	unprecedented	ADJ
fnp-5377	116	8	light	light	NOUN
fnp-5377	116	9	on	on	ADP
fnp-5377	116	10	the	the	DET
fnp-5377	116	11	unique	unique	ADJ
fnp-5377	116	12	developmental	developmental	ADJ
fnp-5377	116	13	and	and	CCONJ
fnp-5377	116	14	epigenetic	epigenetic	ADJ
fnp-5377	116	15	roots	root	NOUN
fnp-5377	116	16	of	of	ADP
fnp-5377	116	17	a	a	DET
fnp-5377	116	18	l-2	l-2	PROPN
fnp-5377	116	19	-	-	PUNCT
fnp-5377	116	20	hga	hga	PROPN
fnp-5377	116	21	associated	associated	ADJ
fnp-5377	116	22	glioma	glioma	NOUN
fnp-5377	116	23	.	.	PUNCT
fnp-5377	117	1	further	further	ADJ
fnp-5377	117	2	studies	study	NOUN
fnp-5377	117	3	are	be	AUX
fnp-5377	117	4	necessary	necessary	ADJ
fnp-5377	117	5	to	to	PART
fnp-5377	117	6	unravel	unravel	VERB
fnp-5377	117	7	how	how	SCONJ
fnp-5377	117	8	exactly	exactly	ADV
fnp-5377	117	9	the	the	DET
fnp-5377	117	10	oncogenetic	oncogenetic	ADJ
fnp-5377	117	11	mechanism	mechanism	NOUN
fnp-5377	117	12	of	of	ADP
fnp-5377	117	13	elevated	elevated	ADJ
fnp-5377	117	14	l-2	l-2	PROPN
fnp-5377	117	15	-	-	PUNCT
fnp-5377	117	16	hg	hg	PROPN
fnp-5377	117	17	is	be	AUX
fnp-5377	117	18	different	different	ADJ
fnp-5377	117	19	from	from	ADP
fnp-5377	117	20	that	that	PRON
fnp-5377	117	21	of	of	ADP
fnp-5377	117	22	its	its	PRON
fnp-5377	117	23	enantiomer	enantiomer	NOUN
fnp-5377	117	24	d-2	d-2	NOUN
fnp-5377	117	25	-	-	PUNCT
fnp-5377	117	26	hg	hg	NOUN
fnp-5377	117	27	.	.	PUNCT
fnp-5377	118	1	based	base	VERB
fnp-5377	118	2	on	on	ADP
fnp-5377	118	3	the	the	DET
fnp-5377	118	4	literature	literature	NOUN
fnp-5377	118	5	,	,	PUNCT
fnp-5377	118	6	the	the	DET
fnp-5377	118	7	prognosis	prognosis	NOUN
fnp-5377	118	8	for	for	ADP
fnp-5377	118	9	l-2	l-2	PROPN
fnp-5377	118	10	-	-	PUNCT
fnp-5377	118	11	hga	hga	PROPN
fnp-5377	118	12	patients	patient	NOUN
fnp-5377	118	13	suffering	suffer	VERB
fnp-5377	118	14	from	from	ADP
fnp-5377	118	15	a	a	DET
fnp-5377	118	16	cns	cns	NOUN
fnp-5377	118	17	tumor	tumor	NOUN
fnp-5377	118	18	appears	appear	VERB
fnp-5377	118	19	to	to	PART
fnp-5377	118	20	be	be	AUX
fnp-5377	118	21	poor	poor	ADJ
fnp-5377	118	22	.	.	PUNCT
fnp-5377	119	1	among	among	ADP
fnp-5377	119	2	the	the	DET
fnp-5377	119	3	documented	document	VERB
fnp-5377	119	4	cases	case	NOUN
fnp-5377	119	5	,	,	PUNCT
fnp-5377	119	6	the	the	DET
fnp-5377	119	7	patients	patient	NOUN
fnp-5377	119	8	experienced	experience	VERB
fnp-5377	119	9	death	death	NOUN
fnp-5377	119	10	with	with	ADP
fnp-5377	119	11	a	a	DET
fnp-5377	119	12	mean	mean	ADJ
fnp-5377	119	13	survival	survival	NOUN
fnp-5377	119	14	of	of	ADP
fnp-5377	119	15	10.8	10.8	NUM
fnp-5377	119	16	months	month	NOUN
fnp-5377	119	17	after	after	ADP
fnp-5377	119	18	diagnosis	diagnosis	NOUN
fnp-5377	119	19	,	,	PUNCT
fnp-5377	119	20	although	although	SCONJ
fnp-5377	119	21	this	this	PRON
fnp-5377	119	22	is	be	AUX
fnp-5377	119	23	based	base	VERB
fnp-5377	119	24	on	on	ADP
fnp-5377	119	25	limited	limited	ADJ
fnp-5377	119	26	data	datum	NOUN
fnp-5377	119	27	.	.	PUNCT
fnp-5377	120	1	this	this	DET
fnp-5377	120	2	poor	poor	ADJ
fnp-5377	120	3	outcome	outcome	NOUN
fnp-5377	120	4	may	may	AUX
fnp-5377	120	5	partly	partly	ADV
fnp-5377	120	6	be	be	AUX
fnp-5377	120	7	explained	explain	VERB
fnp-5377	120	8	by	by	ADP
fnp-5377	120	9	delay	delay	NOUN
fnp-5377	120	10	in	in	ADP
fnp-5377	120	11	the	the	DET
fnp-5377	120	12	diagnosis	diagnosis	NOUN
fnp-5377	120	13	of	of	ADP
fnp-5377	120	14	these	these	DET
fnp-5377	120	15	tumors	tumor	NOUN
fnp-5377	120	16	,	,	PUNCT
fnp-5377	120	17	e.g.	e.g.	ADV
fnp-5377	120	18	,	,	PUNCT
fnp-5377	120	19	because	because	SCONJ
fnp-5377	120	20	on	on	ADP
fnp-5377	120	21	mri	mri	NOUN
fnp-5377	120	22	scans	scan	NOUN
fnp-5377	120	23	the	the	DET
fnp-5377	120	24	tumors	tumor	NOUN
fnp-5377	120	25	are	be	AUX
fnp-5377	120	26	often	often	ADV
fnp-5377	120	27	not	not	PART
fnp-5377	120	28	clearly	clearly	ADV
fnp-5377	120	29	delineated	delineated	ADJ
fnp-5377	120	30	and/or	and/or	CCONJ
fnp-5377	120	31	difficult	difficult	ADJ
fnp-5377	120	32	to	to	PART
fnp-5377	120	33	distinguish	distinguish	VERB
fnp-5377	120	34	from	from	ADP
fnp-5377	120	35	diseased	diseased	ADJ
fnp-5377	120	36	non	non	ADJ
fnp-5377	120	37	-	-	ADJ
fnp-5377	120	38	neoplastic	neoplastic	ADJ
fnp-5377	120	39	brain	brain	NOUN
fnp-5377	120	40	tissue	tissue	NOUN
fnp-5377	120	41	.	.	PUNCT
fnp-5377	121	1	additionally	additionally	ADV
fnp-5377	121	2	,	,	PUNCT
fnp-5377	121	3	among	among	ADP
fnp-5377	121	4	the	the	DET
fnp-5377	121	5	reported	report	VERB
fnp-5377	121	6	patients	patient	NOUN
fnp-5377	121	7	,	,	PUNCT
fnp-5377	121	8	one	one	NUM
fnp-5377	121	9	individual	individual	NOUN
fnp-5377	121	10	(	(	PUNCT
fnp-5377	121	11	case	case	NOUN
fnp-5377	121	12	19	19	NUM
fnp-5377	121	13	)	)	PUNCT
fnp-5377	121	14	was	be	AUX
fnp-5377	121	15	described	describe	VERB
fnp-5377	121	16	with	with	ADP
fnp-5377	121	17	a	a	DET
fnp-5377	121	18	second	second	ADJ
fnp-5377	121	19	tumor	tumor	NOUN
fnp-5377	121	20	diagnosed	diagnose	VERB
fnp-5377	121	21	40	40	NUM
fnp-5377	121	22	months	month	NOUN
fnp-5377	121	23	after	after	ADP
fnp-5377	121	24	initial	initial	ADJ
fnp-5377	121	25	diagnosis	diagnosis	NOUN
fnp-5377	121	26	and	and	CCONJ
fnp-5377	121	27	with	with	ADP
fnp-5377	121	28	the	the	DET
fnp-5377	121	29	same	same	ADJ
fnp-5377	121	30	histological	histological	ADJ
fnp-5377	121	31	and	and	CCONJ
fnp-5377	121	32	molecular	molecular	ADJ
fnp-5377	121	33	characteristics	characteristic	NOUN
fnp-5377	121	34	as	as	ADP
fnp-5377	121	35	the	the	DET
fnp-5377	121	36	first.21	first.21	PROPN
fnp-5377	121	37	conclusion	conclusion	NOUN
fnp-5377	121	38	this	this	PRON
fnp-5377	121	39	is	be	AUX
fnp-5377	121	40	the	the	DET
fnp-5377	121	41	first	first	ADJ
fnp-5377	121	42	report	report	NOUN
fnp-5377	121	43	of	of	ADP
fnp-5377	121	44	a	a	DET
fnp-5377	121	45	comprehensive	comprehensive	ADJ
fnp-5377	121	46	molecular	molecular	ADJ
fnp-5377	121	47	analysis	analysis	NOUN
fnp-5377	121	48	of	of	ADP
fnp-5377	121	49	a	a	DET
fnp-5377	121	50	challenging	challenge	VERB
fnp-5377	121	51	-	-	PUNCT
fnp-5377	121	52	to	to	PART
fnp-5377	121	53	-	-	PUNCT
fnp-5377	121	54	classify	classify	VERB
fnp-5377	121	55	cns	cns	NOUN
fnp-5377	121	56	neoplasm	neoplasm	NOUN
fnp-5377	121	57	in	in	ADP
fnp-5377	121	58	a	a	DET
fnp-5377	121	59	teenager	teenager	NOUN
fnp-5377	121	60	known	know	VERB
fnp-5377	121	61	to	to	PART
fnp-5377	121	62	suffer	suffer	VERB
fnp-5377	121	63	from	from	ADP
fnp-5377	121	64	l-2	l-2	PROPN
fnp-5377	121	65	-	-	PUNCT
fnp-5377	121	66	hga	hga	PROPN
fnp-5377	121	67	.	.	PUNCT
fnp-5377	122	1	intriguingly	intriguingly	ADV
fnp-5377	122	2	,	,	PUNCT
fnp-5377	122	3	we	we	PRON
fnp-5377	122	4	found	find	VERB
fnp-5377	122	5	that	that	SCONJ
fnp-5377	122	6	elevated	elevated	ADJ
fnp-5377	122	7	levels	level	NOUN
fnp-5377	122	8	of	of	ADP
fnp-5377	122	9	l-2	l-2	PROPN
fnp-5377	122	10	-	-	PUNCT
fnp-5377	122	11	hg	hg	PROPN
fnp-5377	122	12	resulted	result	VERB
fnp-5377	122	13	in	in	ADP
fnp-5377	122	14	a	a	DET
fnp-5377	122	15	tumor	tumor	NOUN
fnp-5377	122	16	with	with	ADP
fnp-5377	122	17	characteristics	characteristic	NOUN
fnp-5377	122	18	of	of	ADP
fnp-5377	122	19	idh	idh	NOUN
fnp-5377	122	20	-	-	PUNCT
fnp-5377	122	21	wildtype	wildtype	NOUN
fnp-5377	122	22	rather	rather	ADV
fnp-5377	122	23	than	than	ADP
fnp-5377	122	24	of	of	ADP
fnp-5377	122	25	idh	idh	NOUN
fnp-5377	122	26	-	-	PUNCT
fnp-5377	122	27	mutant	mutant	NOUN
fnp-5377	122	28	diffuse	diffuse	NOUN
fnp-5377	122	29	gliomas	glioma	NOUN
fnp-5377	122	30	,	,	PUNCT
fnp-5377	122	31	including	include	VERB
fnp-5377	122	32	a	a	DET
fnp-5377	122	33	lack	lack	NOUN
fnp-5377	122	34	of	of	ADP
fnp-5377	122	35	g	g	NOUN
fnp-5377	122	36	-	-	PUNCT
fnp-5377	122	37	cimp	cimp	NOUN
fnp-5377	122	38	in	in	ADP
fnp-5377	122	39	the	the	DET
fnp-5377	122	40	tumor	tumor	NOUN
fnp-5377	122	41	of	of	ADP
fnp-5377	122	42	our	our	PRON
fnp-5377	122	43	patient	patient	NOUN
fnp-5377	122	44	.	.	PUNCT
fnp-5377	123	1	our	our	PRON
fnp-5377	123	2	study	study	NOUN
fnp-5377	123	3	thereby	thereby	ADV
fnp-5377	123	4	illustrates	illustrate	VERB
fnp-5377	123	5	that	that	SCONJ
fnp-5377	123	6	the	the	DET
fnp-5377	123	7	oncogenic	oncogenic	ADJ
fnp-5377	123	8	mechanism	mechanism	NOUN
fnp-5377	123	9	of	of	ADP
fnp-5377	123	10	increased	increase	VERB
fnp-5377	123	11	l-2	l-2	PROPN
fnp-5377	123	12	-	-	PUNCT
fnp-5377	123	13	hg	hg	PROPN
fnp-5377	123	14	levels	level	NOUN
fnp-5377	123	15	in	in	ADP
fnp-5377	123	16	diffuse	diffuse	ADJ
fnp-5377	123	17	gliomas	glioma	NOUN
fnp-5377	123	18	is	be	AUX
fnp-5377	123	19	different	different	ADJ
fnp-5377	123	20	from	from	ADP
fnp-5377	123	21	that	that	PRON
fnp-5377	123	22	caused	cause	VERB
fnp-5377	123	23	by	by	ADP
fnp-5377	123	24	d-2	d-2	NOUN
fnp-5377	123	25	-	-	PUNCT
fnp-5377	123	26	hg	hg	NOUN
fnp-5377	123	27	accumulation	accumulation	NOUN
fnp-5377	123	28	in	in	ADP
fnp-5377	123	29	idh	idh	NOUN
fnp-5377	123	30	-	-	PUNCT
fnp-5377	123	31	mutant	mutant	NOUN
fnp-5377	123	32	diffuse	diffuse	NOUN
fnp-5377	123	33	gliomas	glioma	NOUN
fnp-5377	123	34	.	.	PUNCT
fnp-5377	124	1	acknowledgments	acknowledgment	NOUN
fnp-5377	124	2	we	we	PRON
fnp-5377	124	3	kindly	kindly	ADV
fnp-5377	124	4	acknowledge	acknowledge	VERB
fnp-5377	124	5	prof	prof	PROPN
fnp-5377	124	6	.	.	PUNCT
fnp-5377	125	1	ken	ken	PROPN
fnp-5377	125	2	aldape	aldape	PROPN
fnp-5377	125	3	and	and	CCONJ
fnp-5377	125	4	zied	zie	VERB
fnp-5377	125	5	abdullaev	abdullaev	NOUN
fnp-5377	125	6	for	for	ADP
fnp-5377	125	7	providing	provide	VERB
fnp-5377	125	8	methylation	methylation	NOUN
fnp-5377	125	9	classification	classification	NOUN
fnp-5377	125	10	results	result	NOUN
fnp-5377	125	11	of	of	ADP
fnp-5377	125	12	the	the	DET
fnp-5377	125	13	tumor	tumor	NOUN
fnp-5377	125	14	of	of	ADP
fnp-5377	125	15	our	our	PRON
fnp-5377	125	16	patient	patient	NOUN
fnp-5377	125	17	using	use	VERB
fnp-5377	125	18	the	the	DET
fnp-5377	125	19	bethesda	bethesda	NOUN
fnp-5377	125	20	(	(	PUNCT
fnp-5377	125	21	nih	nih	PROPN
fnp-5377	125	22	/	/	SYM
fnp-5377	125	23	nci	nci	PROPN
fnp-5377	125	24	)	)	PUNCT
fnp-5377	125	25	methylation	methylation	NOUN
fnp-5377	125	26	classifier	classifier	NOUN
fnp-5377	125	27	.	.	PUNCT
fnp-5377	126	1	author	author	NOUN
fnp-5377	126	2	contributions	contribution	NOUN
fnp-5377	126	3	fc	fc	PROPN
fnp-5377	126	4	,	,	PUNCT
fnp-5377	126	5	pw	pw	PROPN
fnp-5377	126	6	,	,	PUNCT
fnp-5377	126	7	pjf	pjf	PROPN
fnp-5377	126	8	,	,	PUNCT
fnp-5377	126	9	msvdk	msvdk	NOUN
fnp-5377	126	10	,	,	PUNCT
fnp-5377	126	11	and	and	CCONJ
fnp-5377	126	12	megk	megk	PROPN
fnp-5377	126	13	established	establish	VERB
fnp-5377	126	14	the	the	DET
fnp-5377	126	15	study	study	NOUN
fnp-5377	126	16	concept	concept	NOUN
fnp-5377	126	17	and	and	CCONJ
fnp-5377	126	18	design	design	NOUN
fnp-5377	126	19	.	.	PUNCT
fnp-5377	127	1	fc	fc	PROPN
fnp-5377	127	2	,	,	PUNCT
fnp-5377	127	3	pw	pw	PROPN
fnp-5377	127	4	and	and	CCONJ
fnp-5377	127	5	megk	megk	PROPN
fnp-5377	127	6	performed	perform	VERB
fnp-5377	127	7	the	the	DET
fnp-5377	127	8	writing	writing	NOUN
fnp-5377	127	9	of	of	ADP
fnp-5377	127	10	the	the	DET
fnp-5377	127	11	paper	paper	NOUN
fnp-5377	127	12	.	.	PUNCT
fnp-5377	128	1	pjf	pjf	PROPN
fnp-5377	128	2	,	,	PUNCT
fnp-5377	128	3	ea	ea	NOUN
fnp-5377	128	4	,	,	PUNCT
fnp-5377	128	5	fh	fh	PROPN
fnp-5377	128	6	,	,	PUNCT
fnp-5377	128	7	kms	kms	PROPN
fnp-5377	128	8	,	,	PUNCT
fnp-5377	128	9	msvdk	msvdk	PROPN
fnp-5377	128	10	and	and	CCONJ
fnp-5377	128	11	megk	megk	PROPN
fnp-5377	128	12	contributed	contribute	VERB
fnp-5377	128	13	the	the	DET
fnp-5377	128	14	figures	figure	NOUN
fnp-5377	128	15	.	.	PUNCT
fnp-5377	129	1	all	all	DET
fnp-5377	129	2	authors	author	NOUN
fnp-5377	129	3	contributed	contribute	VERB
fnp-5377	129	4	essential	essential	ADJ
fnp-5377	129	5	‘	'	PUNCT
fnp-5377	129	6	building	building	NOUN
fnp-5377	129	7	blocks	block	NOUN
fnp-5377	129	8	’	'	PUNCT
fnp-5377	129	9	for	for	ADP
fnp-5377	129	10	this	this	DET
fnp-5377	129	11	paper	paper	NOUN
fnp-5377	129	12	and	and	CCONJ
fnp-5377	129	13	have	have	AUX
fnp-5377	129	14	read	read	VERB
fnp-5377	129	15	,	,	PUNCT
fnp-5377	129	16	edited	edit	VERB
fnp-5377	129	17	and	and	CCONJ
fnp-5377	129	18	approved	approve	VERB
fnp-5377	129	19	the	the	DET
fnp-5377	129	20	final	final	ADJ
fnp-5377	129	21	version	version	NOUN
fnp-5377	129	22	of	of	ADP
fnp-5377	129	23	the	the	DET
fnp-5377	129	24	manuscript	manuscript	NOUN
fnp-5377	129	25	.	.	PUNCT
fnp-5377	130	1	competing	compete	VERB
fnp-5377	130	2	interests	interest	NOUN
fnp-5377	130	3	the	the	DET
fnp-5377	130	4	authors	author	NOUN
fnp-5377	130	5	declare	declare	VERB
fnp-5377	130	6	no	no	DET
fnp-5377	130	7	potential	potential	ADJ
fnp-5377	130	8	conflicts	conflict	NOUN
fnp-5377	130	9	of	of	ADP
fnp-5377	130	10	interest	interest	NOUN
fnp-5377	130	11	with	with	ADP
fnp-5377	130	12	respect	respect	NOUN
fnp-5377	130	13	to	to	ADP
fnp-5377	130	14	the	the	DET
fnp-5377	130	15	research	research	NOUN
fnp-5377	130	16	,	,	PUNCT
fnp-5377	130	17	authorship	authorship	NOUN
fnp-5377	130	18	,	,	PUNCT
fnp-5377	130	19	and/or	and/or	CCONJ
fnp-5377	130	20	publication	publication	NOUN
fnp-5377	130	21	of	of	ADP
fnp-5377	130	22	this	this	DET
fnp-5377	130	23	article	article	NOUN
fnp-5377	130	24	.	.	PUNCT
fnp-5377	131	1	references	reference	NOUN
fnp-5377	131	2	1	1	NUM
fnp-5377	131	3	.	.	PUNCT
fnp-5377	131	4	duran	duran	PROPN
fnp-5377	131	5	m	m	PROPN
fnp-5377	131	6	,	,	PUNCT
fnp-5377	131	7	kamerling	kamerle	VERB
fnp-5377	131	8	jp	jp	NOUN
fnp-5377	131	9	,	,	PUNCT
fnp-5377	131	10	bakker	bakker	PROPN
fnp-5377	131	11	hd	hd	PROPN
fnp-5377	131	12	,	,	PUNCT
fnp-5377	131	13	van	van	PROPN
fnp-5377	131	14	gennip	gennip	PROPN
fnp-5377	131	15	ah	ah	INTJ
fnp-5377	131	16	,	,	PUNCT
fnp-5377	131	17	wadman	wadman	NOUN
fnp-5377	131	18	sk	sk	PROPN
fnp-5377	131	19	.	.	PUNCT
fnp-5377	131	20	l-2	l-2	PROPN
fnp-5377	131	21	-	-	PUNCT
fnp-5377	131	22	hydroxyglutaric	hydroxyglutaric	NOUN
fnp-5377	131	23	aciduria	aciduria	NOUN
fnp-5377	131	24	:	:	PUNCT
fnp-5377	131	25	an	an	DET
fnp-5377	131	26	inborn	inborn	ADJ
fnp-5377	131	27	error	error	NOUN
fnp-5377	131	28	of	of	ADP
fnp-5377	131	29	metabolism	metabolism	NOUN
fnp-5377	131	30	?	?	PUNCT
fnp-5377	132	1	journal	journal	NOUN
fnp-5377	132	2	of	of	ADP
fnp-5377	132	3	inherited	inherit	VERB
fnp-5377	132	4	metabolic	metabolic	NOUN
fnp-5377	132	5	disease	disease	NOUN
fnp-5377	132	6	3	3	NUM
fnp-5377	132	7	,	,	PUNCT
fnp-5377	132	8	109	109	NUM
fnp-5377	132	9	-	-	SYM
fnp-5377	132	10	112	112	NUM
fnp-5377	132	11	(	(	PUNCT
fnp-5377	132	12	1980	1980	NUM
fnp-5377	132	13	)	)	PUNCT
fnp-5377	132	14	.	.	PUNCT
fnp-5377	133	1	https://doi.org/10.1007/bf02312543	https://doi.org/10.1007/bf02312543	NOUN
fnp-5377	134	1	2	2	NUM
fnp-5377	134	2	.	.	PUNCT
fnp-5377	134	3	patay	patay	PROPN
fnp-5377	134	4	z	z	PROPN
fnp-5377	134	5	,	,	PUNCT
fnp-5377	134	6	mills	mills	PROPN
fnp-5377	134	7	jc	jc	PROPN
fnp-5377	134	8	,	,	PUNCT
fnp-5377	134	9	lobel	lobel	PROPN
fnp-5377	134	10	u	u	PROPN
fnp-5377	134	11	,	,	PUNCT
fnp-5377	134	12	lambert	lambert	PROPN
fnp-5377	134	13	a	a	PROPN
fnp-5377	134	14	,	,	PUNCT
fnp-5377	134	15	sablauer	sablauer	PROPN
fnp-5377	134	16	a	a	NOUN
fnp-5377	134	17	,	,	PUNCT
fnp-5377	134	18	ellison	ellison	PROPN
fnp-5377	134	19	dw	dw	PROPN
fnp-5377	134	20	.	.	PROPN
fnp-5377	134	21	cerebral	cerebral	ADJ
fnp-5377	134	22	neoplasms	neoplasm	NOUN
fnp-5377	134	23	in	in	ADP
fnp-5377	134	24	l-2	l-2	PROPN
fnp-5377	134	25	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	134	26	aciduria	aciduria	NOUN
fnp-5377	134	27	:	:	PUNCT
fnp-5377	134	28	3	3	NUM
fnp-5377	134	29	new	new	ADJ
fnp-5377	134	30	cases	case	NOUN
fnp-5377	134	31	and	and	CCONJ
fnp-5377	134	32	meta	meta	NOUN
fnp-5377	134	33	-	-	PUNCT
fnp-5377	134	34	analysis	analysis	NOUN
fnp-5377	134	35	of	of	ADP
fnp-5377	134	36	literature	literature	NOUN
fnp-5377	134	37	data	datum	NOUN
fnp-5377	134	38	.	.	PUNCT
fnp-5377	135	1	ajnr	ajnr	PROPN
fnp-5377	135	2	american	american	PROPN
fnp-5377	135	3	journal	journal	PROPN
fnp-5377	135	4	of	of	ADP
fnp-5377	135	5	neuroradiology	neuroradiology	NOUN
fnp-5377	135	6	33	33	NUM
fnp-5377	135	7	,	,	PUNCT
fnp-5377	135	8	940	940	NUM
fnp-5377	135	9	-	-	SYM
fnp-5377	135	10	943	943	NUM
fnp-5377	135	11	(	(	PUNCT
fnp-5377	135	12	2012	2012	NUM
fnp-5377	135	13	)	)	PUNCT
fnp-5377	135	14	.	.	PUNCT
fnp-5377	136	1	https://doi.org/10.3174/ajnr.a2869	https://doi.org/10.3174/ajnr.a2869	PROPN
fnp-5377	136	2	3	3	NUM
fnp-5377	136	3	.	.	PUNCT
fnp-5377	137	1	barth	barth	PROPN
fnp-5377	137	2	pg	pg	PROPN
fnp-5377	137	3	,	,	PUNCT
fnp-5377	137	4	et	et	PROPN
fnp-5377	137	5	al	al	PROPN
fnp-5377	137	6	.	.	PUNCT
fnp-5377	138	1	l-2	l-2	PROPN
fnp-5377	138	2	-	-	PUNCT
fnp-5377	138	3	hydroxyglutaric	hydroxyglutaric	PROPN
fnp-5377	138	4	acidemia	acidemia	NOUN
fnp-5377	138	5	:	:	PUNCT
fnp-5377	138	6	a	a	DET
fnp-5377	138	7	novel	novel	ADJ
fnp-5377	138	8	inherited	inherit	VERB
fnp-5377	138	9	neurometabolic	neurometabolic	ADJ
fnp-5377	138	10	disease	disease	NOUN
fnp-5377	138	11	.	.	PUNCT
fnp-5377	139	1	annals	annal	NOUN
fnp-5377	139	2	of	of	ADP
fnp-5377	139	3	neurology	neurology	NOUN
fnp-5377	139	4	32	32	NUM
fnp-5377	139	5	,	,	PUNCT
fnp-5377	139	6	66	66	NUM
fnp-5377	139	7	-	-	SYM
fnp-5377	139	8	71	71	NUM
fnp-5377	139	9	(	(	PUNCT
fnp-5377	139	10	1992	1992	NUM
fnp-5377	139	11	)	)	PUNCT
fnp-5377	139	12	.	.	PUNCT
fnp-5377	140	1	https://doi.org/10.1002/ana.410320111	https://doi.org/10.1002/ana.410320111	PROPN
fnp-5377	140	2	4	4	NUM
fnp-5377	140	3	.	.	PUNCT
fnp-5377	140	4	goffette	goffette	PROPN
fnp-5377	140	5	sm	sm	PROPN
fnp-5377	140	6	,	,	PUNCT
fnp-5377	140	7	duprez	duprez	PROPN
fnp-5377	140	8	tp	tp	PROPN
fnp-5377	140	9	,	,	PUNCT
fnp-5377	140	10	nassogne	nassogne	PROPN
fnp-5377	140	11	mc	mc	PROPN
fnp-5377	140	12	,	,	PUNCT
fnp-5377	140	13	vincent	vincent	PROPN
fnp-5377	140	14	mf	mf	PROPN
fnp-5377	140	15	,	,	PUNCT
fnp-5377	140	16	jakobs	jakobs	PROPN
fnp-5377	140	17	c	c	PROPN
fnp-5377	140	18	,	,	PUNCT
fnp-5377	140	19	sindic	sindic	ADJ
fnp-5377	140	20	cj	cj	NOUN
fnp-5377	140	21	.	.	PUNCT
fnp-5377	141	1	l-2	l-2	PROPN
fnp-5377	141	2	-	-	PUNCT
fnp-5377	141	3	hydroxyglutaric	hydroxyglutaric	NOUN
fnp-5377	141	4	aciduria	aciduria	NOUN
fnp-5377	141	5	:	:	PUNCT
fnp-5377	141	6	clinical	clinical	ADJ
fnp-5377	141	7	,	,	PUNCT
fnp-5377	141	8	genetic	genetic	ADJ
fnp-5377	141	9	,	,	PUNCT
fnp-5377	141	10	and	and	CCONJ
fnp-5377	141	11	brain	brain	NOUN
fnp-5377	141	12	mri	mri	NOUN
fnp-5377	141	13	characteristics	characteristic	NOUN
fnp-5377	141	14	in	in	ADP
fnp-5377	141	15	two	two	NUM
fnp-5377	141	16	adult	adult	NOUN
fnp-5377	141	17	sisters	sister	NOUN
fnp-5377	141	18	.	.	PUNCT
fnp-5377	142	1	european	european	PROPN
fnp-5377	142	2	journal	journal	PROPN
fnp-5377	142	3	of	of	ADP
fnp-5377	142	4	neurology	neurology	NOUN
fnp-5377	142	5	13	13	NUM
fnp-5377	142	6	,	,	PUNCT
fnp-5377	142	7	499	499	NUM
fnp-5377	142	8	-	-	SYM
fnp-5377	142	9	504	504	NUM
fnp-5377	142	10	(	(	PUNCT
fnp-5377	142	11	2006	2006	NUM
fnp-5377	142	12	)	)	PUNCT
fnp-5377	142	13	.	.	PUNCT
fnp-5377	143	1	https://doi.org/10.1111/j.1468-1331.2006.01282.x	https://doi.org/10.1111/j.1468-1331.2006.01282.x	PROPN
fnp-5377	143	2	5	5	X
fnp-5377	143	3	.	.	PUNCT
fnp-5377	144	1	moroni	moroni	PROPN
fnp-5377	144	2	i	i	PROPN
fnp-5377	144	3	,	,	PUNCT
fnp-5377	144	4	et	et	PROPN
fnp-5377	144	5	al	al	PROPN
fnp-5377	144	6	.	.	PUNCT
fnp-5377	145	1	l-2	l-2	PROPN
fnp-5377	145	2	-	-	PUNCT
fnp-5377	145	3	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	145	4	aciduria	aciduria	NOUN
fnp-5377	145	5	and	and	CCONJ
fnp-5377	145	6	brain	brain	NOUN
fnp-5377	145	7	malignant	malignant	ADJ
fnp-5377	145	8	tumors	tumor	NOUN
fnp-5377	145	9	:	:	PUNCT
fnp-5377	145	10	a	a	DET
fnp-5377	145	11	predisposing	predispose	VERB
fnp-5377	145	12	condition	condition	NOUN
fnp-5377	145	13	?	?	PUNCT
fnp-5377	146	1	neurology	neurology	NOUN
fnp-5377	146	2	62	62	NUM
fnp-5377	146	3	,	,	PUNCT
fnp-5377	146	4	1882	1882	NUM
fnp-5377	146	5	-	-	SYM
fnp-5377	146	6	1884	1884	NUM
fnp-5377	146	7	(	(	PUNCT
fnp-5377	146	8	2004	2004	NUM
fnp-5377	146	9	)	)	PUNCT
fnp-5377	146	10	.	.	PUNCT
fnp-5377	147	1	https://doi.org/10.1212/01.wnl.0000125335.21381.87	https://doi.org/10.1212/01.wnl.0000125335.21381.87	PROPN
fnp-5377	148	1	6	6	NUM
fnp-5377	148	2	.	.	X
fnp-5377	148	3	rzem	rzem	PROPN
fnp-5377	148	4	r	r	NOUN
fnp-5377	148	5	,	,	PUNCT
fnp-5377	148	6	et	et	PROPN
fnp-5377	148	7	al	al	PROPN
fnp-5377	148	8	.	.	PUNCT
fnp-5377	149	1	a	a	DET
fnp-5377	149	2	gene	gene	NOUN
fnp-5377	149	3	encoding	encode	VERB
fnp-5377	149	4	a	a	DET
fnp-5377	149	5	putative	putative	ADJ
fnp-5377	149	6	fad	fad	NOUN
fnp-5377	149	7	-	-	PUNCT
fnp-5377	149	8	dependent	dependent	ADJ
fnp-5377	149	9	l-2	l-2	PROPN
fnp-5377	149	10	-	-	PUNCT
fnp-5377	149	11	hydroxyglutarate	hydroxyglutarate	PROPN
fnp-5377	149	12	dehydrogenase	dehydrogenase	NOUN
fnp-5377	149	13	is	be	AUX
fnp-5377	149	14	mutated	mutate	VERB
fnp-5377	149	15	in	in	ADP
fnp-5377	149	16	l-2	l-2	PROPN
fnp-5377	149	17	-	-	PUNCT
fnp-5377	149	18	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	149	19	aciduria	aciduria	NOUN
fnp-5377	149	20	.	.	PUNCT
fnp-5377	150	1	proceedings	proceeding	NOUN
fnp-5377	150	2	of	of	ADP
fnp-5377	150	3	the	the	DET
fnp-5377	150	4	national	national	PROPN
fnp-5377	150	5	academy	academy	PROPN
fnp-5377	150	6	of	of	ADP
fnp-5377	150	7	sciences	sciences	PROPN
fnp-5377	150	8	of	of	ADP
fnp-5377	150	9	the	the	DET
fnp-5377	150	10	united	united	PROPN
fnp-5377	150	11	states	states	PROPN
fnp-5377	150	12	of	of	ADP
fnp-5377	150	13	america	america	PROPN
fnp-5377	150	14	101	101	NUM
fnp-5377	150	15	,	,	PUNCT
fnp-5377	150	16	16849	16849	NUM
fnp-5377	150	17	-	-	SYM
fnp-5377	150	18	16854	16854	NUM
fnp-5377	150	19	(	(	PUNCT
fnp-5377	150	20	2004	2004	NUM
fnp-5377	150	21	)	)	PUNCT
fnp-5377	150	22	.	.	PUNCT
fnp-5377	151	1	https://doi.org/10.1073/pnas.0404840101	https://doi.org/10.1073/pnas.0404840101	PROPN
fnp-5377	151	2	7	7	NUM
fnp-5377	151	3	.	.	PUNCT
fnp-5377	152	1	steenweg	steenweg	PROPN
fnp-5377	152	2	me	i	PRON
fnp-5377	152	3	,	,	PUNCT
fnp-5377	152	4	et	et	PROPN
fnp-5377	152	5	al	al	PROPN
fnp-5377	152	6	.	.	PUNCT
fnp-5377	153	1	an	an	DET
fnp-5377	153	2	overview	overview	NOUN
fnp-5377	153	3	of	of	ADP
fnp-5377	153	4	l-2	l-2	PROPN
fnp-5377	153	5	-	-	PUNCT
fnp-5377	153	6	hydroxyglutarate	hydroxyglutarate	PROPN
fnp-5377	153	7	dehydrogenase	dehydrogenase	NOUN
fnp-5377	153	8	gene	gene	NOUN
fnp-5377	153	9	(	(	PUNCT
fnp-5377	153	10	l2hgdh	l2hgdh	ADJ
fnp-5377	153	11	)	)	PUNCT
fnp-5377	153	12	variants	variant	NOUN
fnp-5377	153	13	:	:	PUNCT
fnp-5377	153	14	a	a	DET
fnp-5377	153	15	genotype	genotype	NOUN
fnp-5377	153	16	-	-	PUNCT
fnp-5377	153	17	phenotype	phenotype	NOUN
fnp-5377	153	18	study	study	NOUN
fnp-5377	153	19	.	.	PUNCT
fnp-5377	154	1	human	human	ADJ
fnp-5377	154	2	mutation	mutation	NOUN
fnp-5377	154	3	31	31	NUM
fnp-5377	154	4	,	,	PUNCT
fnp-5377	154	5	380	380	NUM
fnp-5377	154	6	-	-	SYM
fnp-5377	154	7	390	390	NUM
fnp-5377	154	8	(	(	PUNCT
fnp-5377	154	9	2010	2010	NUM
fnp-5377	154	10	)	)	PUNCT
fnp-5377	154	11	.	.	PUNCT
fnp-5377	155	1	https://doi.org/10.1002/humu.21197	https://doi.org/10.1002/humu.21197	PROPN
fnp-5377	155	2	8	8	NUM
fnp-5377	155	3	.	.	PUNCT
fnp-5377	156	1	capper	capper	PROPN
fnp-5377	156	2	d	d	PROPN
fnp-5377	156	3	,	,	PUNCT
fnp-5377	156	4	et	et	PROPN
fnp-5377	156	5	al	al	PROPN
fnp-5377	156	6	.	.	PROPN
fnp-5377	157	1	dna	dna	PROPN
fnp-5377	157	2	methylation	methylation	NOUN
fnp-5377	157	3	-	-	PUNCT
fnp-5377	157	4	based	base	VERB
fnp-5377	157	5	classification	classification	NOUN
fnp-5377	157	6	of	of	ADP
fnp-5377	157	7	central	central	ADJ
fnp-5377	157	8	nervous	nervous	ADJ
fnp-5377	157	9	system	system	NOUN
fnp-5377	157	10	tumours	tumour	VERB
fnp-5377	157	11	.	.	PUNCT
fnp-5377	158	1	nature	nature	NOUN
fnp-5377	158	2	555	555	NUM
fnp-5377	158	3	,	,	PUNCT
fnp-5377	158	4	469	469	NUM
fnp-5377	158	5	-	-	NUM
fnp-5377	158	6	474	474	NUM
fnp-5377	158	7	(	(	PUNCT
fnp-5377	158	8	2018	2018	NUM
fnp-5377	158	9	)	)	PUNCT
fnp-5377	158	10	.	.	PUNCT
fnp-5377	159	1	https://doi.org/10.1038/nature26000	https://doi.org/10.1038/nature26000	PROPN
fnp-5377	159	2	9	9	NUM
fnp-5377	159	3	.	.	PUNCT
fnp-5377	159	4	kloosterhof	kloosterhof	PROPN
fnp-5377	159	5	nk	nk	PROPN
fnp-5377	159	6	,	,	PUNCT
fnp-5377	159	7	bralten	bralten	VERB
fnp-5377	159	8	lb	lb	ADP
fnp-5377	159	9	,	,	PUNCT
fnp-5377	159	10	dubbink	dubbink	ADJ
fnp-5377	159	11	hj	hj	PROPN
fnp-5377	159	12	,	,	PUNCT
fnp-5377	159	13	french	french	PROPN
fnp-5377	159	14	pj	pj	PROPN
fnp-5377	159	15	,	,	PUNCT
fnp-5377	159	16	van	van	PROPN
fnp-5377	159	17	den	den	PROPN
fnp-5377	159	18	bent	bent	ADJ
fnp-5377	159	19	mj	mj	PROPN
fnp-5377	159	20	.	.	PROPN
fnp-5377	159	21	isocitrate	isocitrate	PROPN
fnp-5377	159	22	dehydrogenase-1	dehydrogenase-1	PROPN
fnp-5377	159	23	mutations	mutation	NOUN
fnp-5377	159	24	:	:	PUNCT
fnp-5377	159	25	a	a	DET
fnp-5377	159	26	fundamentally	fundamentally	ADV
fnp-5377	159	27	new	new	ADJ
fnp-5377	159	28	understanding	understanding	NOUN
fnp-5377	159	29	of	of	ADP
fnp-5377	159	30	diffuse	diffuse	ADJ
fnp-5377	159	31	glioma	glioma	NOUN
fnp-5377	159	32	?	?	PUNCT
fnp-5377	160	1	lancet	lancet	NOUN
fnp-5377	160	2	oncol	oncol	ADJ
fnp-5377	160	3	12	12	NUM
fnp-5377	160	4	,	,	PUNCT
fnp-5377	160	5	83	83	NUM
fnp-5377	160	6	-	-	SYM
fnp-5377	160	7	91	91	NUM
fnp-5377	160	8	(	(	PUNCT
fnp-5377	160	9	2011	2011	NUM
fnp-5377	160	10	)	)	PUNCT
fnp-5377	160	11	.	.	PUNCT
fnp-5377	161	1	https://doi.org/10.1016/s1470-2045(10)70053-x	https://doi.org/10.1016/s1470-2045(10)70053-x	ADP
fnp-5377	161	2	10	10	NUM
fnp-5377	161	3	.	.	PUNCT
fnp-5377	162	1	turcan	turcan	PROPN
fnp-5377	162	2	s	s	PROPN
fnp-5377	162	3	,	,	PUNCT
fnp-5377	162	4	et	et	PROPN
fnp-5377	162	5	al	al	PROPN
fnp-5377	162	6	.	.	PROPN
fnp-5377	163	1	efficient	efficient	ADJ
fnp-5377	163	2	induction	induction	NOUN
fnp-5377	163	3	of	of	ADP
fnp-5377	163	4	differentiation	differentiation	NOUN
fnp-5377	163	5	and	and	CCONJ
fnp-5377	163	6	growth	growth	NOUN
fnp-5377	163	7	inhibition	inhibition	NOUN
fnp-5377	163	8	in	in	ADP
fnp-5377	163	9	idh1	idh1	NOUN
fnp-5377	163	10	mutant	mutant	ADJ
fnp-5377	163	11	glioma	glioma	NOUN
fnp-5377	163	12	cells	cell	NOUN
fnp-5377	163	13	by	by	ADP
fnp-5377	163	14	the	the	DET
fnp-5377	163	15	dnmt	dnmt	PROPN
fnp-5377	163	16	inhibitor	inhibitor	NOUN
fnp-5377	163	17	decitabine	decitabine	NOUN
fnp-5377	163	18	.	.	PUNCT
fnp-5377	164	1	oncotarget	oncotarget	VERB
fnp-5377	164	2	4	4	NUM
fnp-5377	164	3	,	,	PUNCT
fnp-5377	164	4	1729	1729	NUM
fnp-5377	164	5	-	-	SYM
fnp-5377	164	6	1736	1736	NUM
fnp-5377	164	7	(	(	PUNCT
fnp-5377	164	8	2013	2013	NUM
fnp-5377	164	9	)	)	PUNCT
fnp-5377	164	10	.	.	PUNCT
fnp-5377	165	1	https://doi.org/10.18632/oncotarget.1412	https://doi.org/10.18632/oncotarget.1412	ADP
fnp-5377	165	2	11	11	NUM
fnp-5377	165	3	.	.	PUNCT
fnp-5377	166	1	noushmehr	noushmehr	PROPN
fnp-5377	166	2	h	h	PROPN
fnp-5377	166	3	,	,	PUNCT
fnp-5377	166	4	et	et	PROPN
fnp-5377	166	5	al	al	PROPN
fnp-5377	166	6	.	.	PUNCT
fnp-5377	167	1	identification	identification	NOUN
fnp-5377	167	2	of	of	ADP
fnp-5377	167	3	a	a	DET
fnp-5377	167	4	cpg	cpg	NOUN
fnp-5377	167	5	island	island	NOUN
fnp-5377	167	6	methylator	methylator	PROPN
fnp-5377	167	7	phenotype	phenotype	NOUN
fnp-5377	167	8	that	that	PRON
fnp-5377	167	9	defines	define	VERB
fnp-5377	167	10	a	a	DET
fnp-5377	167	11	distinct	distinct	ADJ
fnp-5377	167	12	subgroup	subgroup	NOUN
fnp-5377	167	13	of	of	ADP
fnp-5377	167	14	glioma	glioma	NOUN
fnp-5377	167	15	.	.	PUNCT
fnp-5377	168	1	cancer	cancer	NOUN
fnp-5377	168	2	cell	cell	NOUN
fnp-5377	168	3	17	17	NUM
fnp-5377	168	4	,	,	PUNCT
fnp-5377	168	5	510	510	NUM
fnp-5377	168	6	-	-	SYM
fnp-5377	168	7	522	522	NUM
fnp-5377	168	8	(	(	PUNCT
fnp-5377	168	9	2010	2010	NUM
fnp-5377	168	10	)	)	PUNCT
fnp-5377	168	11	.	.	PUNCT
fnp-5377	169	1	https://doi.org/10.1016/j.ccr.2010.03.017	https://doi.org/10.1016/j.ccr.2010.03.017	ADP
fnp-5377	169	2	12	12	NUM
fnp-5377	169	3	.	.	PUNCT
fnp-5377	170	1	den	den	PROPN
fnp-5377	170	2	dunnen	dunnen	PROPN
fnp-5377	170	3	jt	jt	PROPN
fnp-5377	170	4	,	,	PUNCT
fnp-5377	170	5	et	et	PROPN
fnp-5377	170	6	al	al	PROPN
fnp-5377	170	7	.	.	PUNCT
fnp-5377	170	8	hgvs	hgv	NOUN
fnp-5377	170	9	recommendations	recommendation	NOUN
fnp-5377	170	10	for	for	ADP
fnp-5377	170	11	the	the	DET
fnp-5377	170	12	description	description	NOUN
fnp-5377	170	13	of	of	ADP
fnp-5377	170	14	sequence	sequence	NOUN
fnp-5377	170	15	variants	variant	NOUN
fnp-5377	170	16	:	:	PUNCT
fnp-5377	170	17	2016	2016	NUM
fnp-5377	170	18	update	update	NOUN
fnp-5377	170	19	.	.	PUNCT
fnp-5377	171	1	human	human	ADJ
fnp-5377	171	2	mutation	mutation	NOUN
fnp-5377	171	3	37	37	NUM
fnp-5377	171	4	,	,	PUNCT
fnp-5377	171	5	564	564	NUM
fnp-5377	171	6	-	-	SYM
fnp-5377	171	7	569	569	NUM
fnp-5377	171	8	(	(	PUNCT
fnp-5377	171	9	2016	2016	NUM
fnp-5377	171	10	)	)	PUNCT
fnp-5377	171	11	.	.	PUNCT
fnp-5377	172	1	https://doi.org/10.1002/humu.22981	https://doi.org/10.1002/humu.22981	X
fnp-5377	173	1	13	13	NUM
fnp-5377	173	2	.	.	PUNCT
fnp-5377	173	3	wu	wu	PROPN
fnp-5377	174	1	z	z	PROPN
fnp-5377	174	2	,	,	PUNCT
fnp-5377	174	3	et	et	PROPN
fnp-5377	174	4	al	al	PROPN
fnp-5377	174	5	.	.	PROPN
fnp-5377	174	6	impact	impact	NOUN
fnp-5377	174	7	of	of	ADP
fnp-5377	174	8	the	the	DET
fnp-5377	174	9	methylation	methylation	NOUN
fnp-5377	174	10	classifier	classifier	NOUN
fnp-5377	174	11	and	and	CCONJ
fnp-5377	174	12	ancillary	ancillary	ADJ
fnp-5377	174	13	methods	method	NOUN
fnp-5377	174	14	on	on	ADP
fnp-5377	174	15	cns	cns	NOUN
fnp-5377	174	16	tumor	tumor	NOUN
fnp-5377	174	17	diagnostics	diagnostic	NOUN
fnp-5377	174	18	.	.	PUNCT
fnp-5377	175	1	neuro	neuro	NOUN
fnp-5377	175	2	-	-	PUNCT
fnp-5377	175	3	oncology	oncology	NOUN
fnp-5377	175	4	24	24	NUM
fnp-5377	175	5	,	,	PUNCT
fnp-5377	175	6	571	571	NUM
fnp-5377	175	7	-	-	SYM
fnp-5377	175	8	581	581	NUM
fnp-5377	175	9	(	(	PUNCT
fnp-5377	175	10	2022	2022	NUM
fnp-5377	175	11	)	)	PUNCT
fnp-5377	175	12	.	.	PUNCT
fnp-5377	176	1	https://doi.org/10.1093/neuonc/noab227	https://doi.org/10.1093/neuonc/noab227	PROPN
fnp-5377	177	1	14	14	NUM
fnp-5377	177	2	.	.	PUNCT
fnp-5377	178	1	cahill	cahill	PROPN
fnp-5377	178	2	d	d	PROPN
fnp-5377	178	3	,	,	PUNCT
fnp-5377	178	4	turcan	turcan	PROPN
fnp-5377	178	5	s.	s.	PROPN
fnp-5377	178	6	origin	origin	PROPN
fnp-5377	178	7	of	of	ADP
fnp-5377	178	8	gliomas	glioma	NOUN
fnp-5377	178	9	.	.	PUNCT
fnp-5377	179	1	semin	semin	PROPN
fnp-5377	179	2	neurol	neurol	PROPN
fnp-5377	179	3	38	38	NUM
fnp-5377	179	4	,	,	PUNCT
fnp-5377	179	5	5	5	NUM
fnp-5377	179	6	-	-	SYM
fnp-5377	179	7	10	10	NUM
fnp-5377	179	8	(	(	PUNCT
fnp-5377	179	9	2018	2018	NUM
fnp-5377	179	10	)	)	PUNCT
fnp-5377	179	11	.	.	PUNCT
fnp-5377	180	1	https://doi.org/10.1055/s-0037-1620238	https://doi.org/10.1055/s-0037-1620238	NOUN
fnp-5377	180	2	15	15	NUM
fnp-5377	180	3	.	.	PUNCT
fnp-5377	181	1	van	van	PROPN
fnp-5377	181	2	den	den	PROPN
fnp-5377	181	3	bent	bent	PROPN
fnp-5377	181	4	mj	mj	PROPN
fnp-5377	181	5	,	,	PUNCT
fnp-5377	181	6	et	et	PROPN
fnp-5377	181	7	al	al	PROPN
fnp-5377	181	8	.	.	PROPN
fnp-5377	181	9	interim	interim	ADJ
fnp-5377	181	10	results	result	NOUN
fnp-5377	181	11	from	from	ADP
fnp-5377	181	12	the	the	DET
fnp-5377	181	13	catnon	catnon	NOUN
fnp-5377	181	14	trial	trial	NOUN
fnp-5377	181	15	(	(	PUNCT
fnp-5377	181	16	eortc	eortc	ADJ
fnp-5377	181	17	study	study	NOUN
fnp-5377	181	18	26053	26053	NUM
fnp-5377	181	19	-	-	SYM
fnp-5377	181	20	22054	22054	NUM
fnp-5377	181	21	)	)	PUNCT
fnp-5377	181	22	of	of	ADP
fnp-5377	181	23	treatment	treatment	NOUN
fnp-5377	181	24	with	with	ADP
fnp-5377	181	25	concurrent	concurrent	ADJ
fnp-5377	181	26	and	and	CCONJ
fnp-5377	181	27	adjuvant	adjuvant	ADJ
fnp-5377	181	28	temozolomide	temozolomide	NOUN
fnp-5377	181	29	for	for	ADP
fnp-5377	181	30	1p/19q	1p/19q	PROPN
fnp-5377	181	31	non	non	ADJ
fnp-5377	181	32	-	-	ADJ
fnp-5377	181	33	co	co	ADJ
fnp-5377	181	34	-	-	ADJ
fnp-5377	181	35	deleted	delete	VERB
fnp-5377	181	36	anaplastic	anaplastic	ADJ
fnp-5377	181	37	glioma	glioma	NOUN
fnp-5377	181	38	:	:	PUNCT
fnp-5377	181	39	a	a	DET
fnp-5377	181	40	phase	phase	NOUN
fnp-5377	181	41	3	3	NUM
fnp-5377	181	42	,	,	PUNCT
fnp-5377	181	43	randomised	randomise	VERB
fnp-5377	181	44	,	,	PUNCT
fnp-5377	181	45	open	open	ADJ
fnp-5377	181	46	-	-	PUNCT
fnp-5377	181	47	label	label	NOUN
fnp-5377	181	48	intergroup	intergroup	NOUN
fnp-5377	181	49	study	study	NOUN
fnp-5377	181	50	.	.	PUNCT
fnp-5377	182	1	lancet	lancet	PROPN
fnp-5377	182	2	(	(	PUNCT
fnp-5377	182	3	london	london	PROPN
fnp-5377	182	4	,	,	PUNCT
fnp-5377	182	5	england	england	PROPN
fnp-5377	182	6	)	)	PUNCT
fnp-5377	182	7	390	390	NUM
fnp-5377	182	8	,	,	PUNCT
fnp-5377	182	9	1645	1645	NUM
fnp-5377	182	10	-	-	SYM
fnp-5377	182	11	1653	1653	NUM
fnp-5377	182	12	(	(	PUNCT
fnp-5377	182	13	2017	2017	NUM
fnp-5377	182	14	)	)	PUNCT
fnp-5377	182	15	.	.	PUNCT
fnp-5377	183	1	https://doi.org/10.1016/s0140-6736(17)31442-3	https://doi.org/10.1016/s0140-6736(17)31442-3	PROPN
fnp-5377	183	2	16	16	NUM
fnp-5377	183	3	.	.	PUNCT
fnp-5377	184	1	who	who	PRON
fnp-5377	184	2	classification	classification	NOUN
fnp-5377	184	3	of	of	ADP
fnp-5377	184	4	central	central	ADJ
fnp-5377	184	5	nervous	nervous	ADJ
fnp-5377	184	6	tumors	tumor	NOUN
fnp-5377	184	7	tumors	tumor	NOUN
fnp-5377	184	8	,	,	PUNCT
fnp-5377	184	9	5	5	NUM
fnp-5377	184	10	edn	edn	NOUN
fnp-5377	184	11	.	.	PUNCT
fnp-5377	185	1	international	international	ADJ
fnp-5377	185	2	agency	agency	NOUN
fnp-5377	185	3	for	for	ADP
fnp-5377	185	4	research	research	NOUN
fnp-5377	185	5	on	on	ADP
fnp-5377	185	6	cancer	cancer	NOUN
fnp-5377	185	7	(	(	PUNCT
fnp-5377	185	8	2021	2021	NUM
fnp-5377	185	9	)	)	PUNCT
fnp-5377	185	10	.	.	PUNCT
fnp-5377	186	1	isbn	isbn	PROPN
fnp-5377	186	2	 	 	SPACE
fnp-5377	186	3	=	=	NOUN
fnp-5377	186	4	 	 	SPACE
fnp-5377	186	5	9789283245087	9789283245087	NUM
fnp-5377	186	6	17	17	NUM
fnp-5377	186	7	.	.	PUNCT
fnp-5377	187	1	mackay	mackay	PROPN
fnp-5377	187	2	a	a	PROPN
fnp-5377	187	3	,	,	PUNCT
fnp-5377	187	4	et	et	PROPN
fnp-5377	187	5	al	al	PROPN
fnp-5377	187	6	.	.	PROPN
fnp-5377	187	7	integrated	integrate	VERB
fnp-5377	187	8	molecular	molecular	ADJ
fnp-5377	187	9	meta	meta	ADJ
fnp-5377	187	10	-	-	PUNCT
fnp-5377	187	11	analysis	analysis	NOUN
fnp-5377	187	12	of	of	ADP
fnp-5377	187	13	1,000	1,000	NUM
fnp-5377	187	14	pediatric	pediatric	ADJ
fnp-5377	187	15	high	high	ADJ
fnp-5377	187	16	-	-	PUNCT
fnp-5377	187	17	grade	grade	NOUN
fnp-5377	187	18	and	and	CCONJ
fnp-5377	187	19	diffuse	diffuse	VERB
fnp-5377	187	20	intrinsic	intrinsic	ADJ
fnp-5377	187	21	pontine	pontine	ADJ
fnp-5377	187	22	glioma	glioma	NOUN
fnp-5377	187	23	.	.	PUNCT
fnp-5377	188	1	cancer	cancer	NOUN
fnp-5377	188	2	cell	cell	NOUN
fnp-5377	188	3	32	32	NUM
fnp-5377	188	4	,	,	PUNCT
fnp-5377	188	5	520	520	NUM
fnp-5377	188	6	-	-	SYM
fnp-5377	188	7	537	537	NUM
fnp-5377	188	8	e525	e525	PROPN
fnp-5377	188	9	(	(	PUNCT
fnp-5377	188	10	2017	2017	NUM
fnp-5377	188	11	)	)	PUNCT
fnp-5377	188	12	.	.	PUNCT
fnp-5377	189	1	https://doi.org/10.1016/j.ccell.2017.08.017	https://doi.org/10.1016/j.ccell.2017.08.017	SYM
fnp-5377	189	2	18	18	NUM
fnp-5377	189	3	.	.	PUNCT
fnp-5377	190	1	sturm	sturm	PROPN
fnp-5377	190	2	d	d	PROPN
fnp-5377	190	3	,	,	PUNCT
fnp-5377	190	4	et	et	PROPN
fnp-5377	190	5	al	al	PROPN
fnp-5377	190	6	.	.	PUNCT
fnp-5377	190	7	new	new	ADJ
fnp-5377	190	8	brain	brain	NOUN
fnp-5377	190	9	tumor	tumor	NOUN
fnp-5377	190	10	entities	entity	NOUN
fnp-5377	190	11	emerge	emerge	VERB
fnp-5377	190	12	from	from	ADP
fnp-5377	190	13	molecular	molecular	ADJ
fnp-5377	190	14	classification	classification	NOUN
fnp-5377	190	15	of	of	ADP
fnp-5377	190	16	cns	cns	NOUN
fnp-5377	190	17	-	-	PUNCT
fnp-5377	190	18	pnets	pnet	NOUN
fnp-5377	190	19	.	.	PUNCT
fnp-5377	191	1	cell	cell	NOUN
fnp-5377	191	2	164	164	NUM
fnp-5377	191	3	,	,	PUNCT
fnp-5377	191	4	1060	1060	NUM
fnp-5377	191	5	-	-	SYM
fnp-5377	191	6	1072	1072	NUM
fnp-5377	191	7	(	(	PUNCT
fnp-5377	191	8	2016	2016	NUM
fnp-5377	191	9	)	)	PUNCT
fnp-5377	191	10	.	.	PUNCT
fnp-5377	192	1	https://doi.org/10.1016/j.cell.2016.01.015	https://doi.org/10.1016/j.cell.2016.01.015	PROPN
fnp-5377	192	2	19	19	NUM
fnp-5377	192	3	.	.	PUNCT
fnp-5377	193	1	thomas	thomas	PROPN
fnp-5377	193	2	dl	dl	PROPN
fnp-5377	193	3	.	.	PROPN
fnp-5377	193	4	2021	2021	NUM
fnp-5377	193	5	updates	update	NOUN
fnp-5377	193	6	to	to	ADP
fnp-5377	193	7	the	the	DET
fnp-5377	193	8	world	world	PROPN
fnp-5377	193	9	health	health	PROPN
fnp-5377	193	10	organization	organization	PROPN
fnp-5377	193	11	classification	classification	NOUN
fnp-5377	193	12	of	of	ADP
fnp-5377	193	13	adult	adult	NOUN
fnp-5377	193	14	-	-	PUNCT
fnp-5377	193	15	type	type	NOUN
fnp-5377	193	16	and	and	CCONJ
fnp-5377	193	17	pediatric	pediatric	ADJ
fnp-5377	193	18	-	-	PUNCT
fnp-5377	193	19	type	type	NOUN
fnp-5377	193	20	diffuse	diffuse	NOUN
fnp-5377	193	21	gliomas	glioma	NOUN
fnp-5377	193	22	:	:	PUNCT
fnp-5377	193	23	a	a	DET
fnp-5377	193	24	clinical	clinical	ADJ
fnp-5377	193	25	practice	practice	NOUN
fnp-5377	193	26	review	review	NOUN
fnp-5377	193	27	.	.	PUNCT
fnp-5377	194	1	chinese	chinese	ADJ
fnp-5377	194	2	clinical	clinical	ADJ
fnp-5377	194	3	oncology	oncology	NOUN
fnp-5377	194	4	12	12	NUM
fnp-5377	194	5	,	,	PUNCT
fnp-5377	194	6	7	7	NUM
fnp-5377	194	7	(	(	PUNCT
fnp-5377	194	8	2023	2023	NUM
fnp-5377	194	9	)	)	PUNCT
fnp-5377	194	10	.	.	PUNCT
fnp-5377	195	1	https://doi.org/10.21037/cco-22-120	https://doi.org/10.21037/cco-22-120	NOUN
fnp-5377	196	1	20	20	NUM
fnp-5377	196	2	.	.	PUNCT
fnp-5377	197	1	capper	capper	PROPN
fnp-5377	197	2	d	d	PROPN
fnp-5377	197	3	,	,	PUNCT
fnp-5377	197	4	et	et	PROPN
fnp-5377	197	5	al	al	PROPN
fnp-5377	197	6	.	.	PROPN
fnp-5377	197	7	practical	practical	ADJ
fnp-5377	197	8	implementation	implementation	NOUN
fnp-5377	197	9	of	of	ADP
fnp-5377	197	10	dna	dna	PROPN
fnp-5377	197	11	methylation	methylation	NOUN
fnp-5377	197	12	and	and	CCONJ
fnp-5377	197	13	copy	copy	NOUN
fnp-5377	197	14	-	-	PUNCT
fnp-5377	197	15	number	number	NOUN
fnp-5377	197	16	-	-	PUNCT
fnp-5377	197	17	based	base	VERB
fnp-5377	197	18	cns	cns	NOUN
fnp-5377	197	19	tumor	tumor	NOUN
fnp-5377	197	20	diagnostics	diagnostic	NOUN
fnp-5377	197	21	:	:	PUNCT
fnp-5377	197	22	the	the	DET
fnp-5377	197	23	heidelberg	heidelberg	NOUN
fnp-5377	197	24	experience	experience	NOUN
fnp-5377	197	25	.	.	PUNCT
fnp-5377	198	1	acta	acta	PROPN
fnp-5377	198	2	neuropathologica	neuropathologica	PROPN
fnp-5377	198	3	136	136	NUM
fnp-5377	198	4	,	,	PUNCT
fnp-5377	198	5	181	181	NUM
fnp-5377	198	6	-	-	SYM
fnp-5377	198	7	210	210	NUM
fnp-5377	198	8	(	(	PUNCT
fnp-5377	198	9	2018	2018	NUM
fnp-5377	198	10	)	)	PUNCT
fnp-5377	198	11	.	.	PUNCT
fnp-5377	199	1	https://doi.org/10.1007/s00401-018-1879-y	https://doi.org/10.1007/s00401-018-1879-y	PROPN
fnp-5377	199	2	21	21	NUM
fnp-5377	199	3	.	.	PUNCT
fnp-5377	200	1	patay	patay	PROPN
fnp-5377	200	2	z	z	PROPN
fnp-5377	200	3	,	,	PUNCT
fnp-5377	200	4	et	et	PROPN
fnp-5377	200	5	al	al	PROPN
fnp-5377	200	6	.	.	PROPN
fnp-5377	200	7	successive	successive	ADJ
fnp-5377	200	8	distinct	distinct	ADJ
fnp-5377	200	9	high	high	ADJ
fnp-5377	200	10	-	-	PUNCT
fnp-5377	200	11	grade	grade	NOUN
fnp-5377	200	12	gliomas	glioma	NOUN
fnp-5377	200	13	in	in	ADP
fnp-5377	200	14	l-2	l-2	PROPN
fnp-5377	200	15	-	-	PUNCT
fnp-5377	200	16	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	200	17	aciduria	aciduria	NOUN
fnp-5377	200	18	.	.	PUNCT
fnp-5377	201	1	journal	journal	PROPN
fnp-5377	201	2	of	of	ADP
fnp-5377	201	3	inherited	inherit	VERB
fnp-5377	201	4	metabolic	metabolic	NOUN
fnp-5377	201	5	disease	disease	NOUN
fnp-5377	201	6	38	38	NUM
fnp-5377	201	7	,	,	PUNCT
fnp-5377	201	8	273	273	NUM
fnp-5377	201	9	-	-	SYM
fnp-5377	201	10	277	277	NUM
fnp-5377	201	11	(	(	PUNCT
fnp-5377	201	12	2015	2015	NUM
fnp-5377	201	13	)	)	PUNCT
fnp-5377	201	14	.	.	PUNCT
fnp-5377	202	1	https://doi.org/10.1007/s10545-014-9782-8	https://doi.org/10.1007/s10545-014-9782-8	NOUN
fnp-5377	202	2	22	22	NUM
fnp-5377	202	3	.	.	PUNCT
fnp-5377	203	1	gunn	gunn	PROPN
fnp-5377	203	2	k	k	PROPN
fnp-5377	203	3	,	,	PUNCT
fnp-5377	203	4	et	et	PROPN
fnp-5377	203	5	al	al	PROPN
fnp-5377	203	6	.	.	PROPN
fnp-5377	204	1	(	(	PUNCT
fnp-5377	204	2	r)-2	r)-2	NOUN
fnp-5377	204	3	-	-	PUNCT
fnp-5377	204	4	hydroxyglutarate	hydroxyglutarate	NOUN
fnp-5377	204	5	inhibits	inhibit	VERB
fnp-5377	204	6	kdm5	kdm5	PROPN
fnp-5377	204	7	histone	histone	PROPN
fnp-5377	204	8	lysine	lysine	NOUN
fnp-5377	204	9	demethylases	demethylase	NOUN
fnp-5377	204	10	to	to	PART
fnp-5377	204	11	drive	drive	VERB
fnp-5377	204	12	transformation	transformation	NOUN
fnp-5377	204	13	in	in	ADP
fnp-5377	204	14	idh	idh	NOUN
fnp-5377	204	15	-	-	PUNCT
fnp-5377	204	16	mutant	mutant	NOUN
fnp-5377	204	17	cancers	cancer	NOUN
fnp-5377	204	18	.	.	PUNCT
fnp-5377	205	1	cancer	cancer	NOUN
fnp-5377	205	2	discov	discov	PROPN
fnp-5377	205	3	13	13	NUM
fnp-5377	205	4	,	,	PUNCT
fnp-5377	205	5	1478	1478	NUM
fnp-5377	205	6	-	-	SYM
fnp-5377	205	7	1497	1497	NUM
fnp-5377	205	8	(	(	PUNCT
fnp-5377	205	9	2023	2023	NUM
fnp-5377	205	10	)	)	PUNCT
fnp-5377	205	11	.	.	PUNCT
fnp-5377	206	1	https://doi.org/10.1158/2159-8290.cd-22-0825	https://doi.org/10.1158/2159-8290.cd-22-0825	PROPN
fnp-5377	206	2	23	23	NUM
fnp-5377	206	3	.	.	PUNCT
fnp-5377	207	1	shelar	shelar	PROPN
fnp-5377	207	2	s	s	PROPN
fnp-5377	207	3	,	,	PUNCT
fnp-5377	207	4	et	et	PROPN
fnp-5377	207	5	al	al	PROPN
fnp-5377	207	6	.	.	PROPN
fnp-5377	208	1	biochemical	biochemical	ADJ
fnp-5377	208	2	and	and	CCONJ
fnp-5377	208	3	epigenetic	epigenetic	ADJ
fnp-5377	208	4	insights	insight	NOUN
fnp-5377	208	5	into	into	ADP
fnp-5377	208	6	l-2	l-2	PROPN
fnp-5377	208	7	-	-	PUNCT
fnp-5377	208	8	hydroxyglutarate	hydroxyglutarate	PROPN
fnp-5377	208	9	,	,	PUNCT
fnp-5377	208	10	a	a	DET
fnp-5377	208	11	potential	potential	ADJ
fnp-5377	208	12	therapeutic	therapeutic	ADJ
fnp-5377	208	13	target	target	NOUN
fnp-5377	208	14	in	in	ADP
fnp-5377	208	15	renal	renal	ADJ
fnp-5377	208	16	cancer	cancer	NOUN
fnp-5377	208	17	.	.	PUNCT
fnp-5377	209	1	clin	clin	PROPN
fnp-5377	209	2	cancer	cancer	NOUN
fnp-5377	209	3	res	re	NOUN
fnp-5377	209	4	24	24	NUM
fnp-5377	209	5	,	,	PUNCT
fnp-5377	209	6	6433	6433	NUM
fnp-5377	209	7	-	-	SYM
fnp-5377	209	8	6446	6446	NUM
fnp-5377	209	9	(	(	PUNCT
fnp-5377	209	10	2018	2018	NUM
fnp-5377	209	11	)	)	PUNCT
fnp-5377	209	12	.	.	PUNCT
fnp-5377	210	1	https://doi.org/10.1158/1078-0432.ccr-18-1727	https://doi.org/10.1158/1078-0432.ccr-18-1727	PROPN
fnp-5377	211	1	24	24	NUM
fnp-5377	211	2	.	.	PUNCT
fnp-5377	211	3	xu	xu	PROPN
fnp-5377	212	1	w	w	PROPN
fnp-5377	212	2	,	,	PUNCT
fnp-5377	212	3	et	et	PROPN
fnp-5377	212	4	al	al	PROPN
fnp-5377	212	5	.	.	PROPN
fnp-5377	213	1	oncometabolite	oncometabolite	PROPN
fnp-5377	213	2	2	2	NUM
fnp-5377	213	3	-	-	PUNCT
fnp-5377	213	4	hydroxyglutarate	hydroxyglutarate	NOUN
fnp-5377	213	5	is	be	AUX
fnp-5377	213	6	a	a	DET
fnp-5377	213	7	competitive	competitive	ADJ
fnp-5377	213	8	inhibitor	inhibitor	NOUN
fnp-5377	213	9	of	of	ADP
fnp-5377	213	10	alpha	alpha	NOUN
fnp-5377	213	11	-	-	PUNCT
fnp-5377	213	12	ketoglutarate	ketoglutarate	NOUN
fnp-5377	213	13	-	-	PUNCT
fnp-5377	213	14	dependent	dependent	ADJ
fnp-5377	213	15	dioxygenases	dioxygenase	NOUN
fnp-5377	213	16	.	.	PUNCT
fnp-5377	214	1	cancer	cancer	NOUN
fnp-5377	214	2	cell	cell	NOUN
fnp-5377	214	3	19	19	NUM
fnp-5377	214	4	,	,	PUNCT
fnp-5377	214	5	17	17	NUM
fnp-5377	214	6	-	-	SYM
fnp-5377	214	7	30	30	NUM
fnp-5377	214	8	(	(	PUNCT
fnp-5377	214	9	2011	2011	NUM
fnp-5377	214	10	)	)	PUNCT
fnp-5377	214	11	.	.	PUNCT
fnp-5377	215	1	https://doi.org/10.1016/j.ccr.2010.12.014	https://doi.org/10.1016/j.ccr.2010.12.014	PROPN
fnp-5377	215	2	25	25	NUM
fnp-5377	215	3	.	.	PUNCT
fnp-5377	216	1	london	london	PROPN
fnp-5377	216	2	f	f	PROPN
fnp-5377	216	3	,	,	PUNCT
fnp-5377	216	4	jeanjean	jeanjean	PROPN
fnp-5377	216	5	a.	a.	PROPN
fnp-5377	216	6	gliomatosis	gliomatosis	PROPN
fnp-5377	216	7	cerebri	cerebri	NOUN
fnp-5377	216	8	in	in	ADP
fnp-5377	216	9	l-2	l-2	PROPN
fnp-5377	216	10	-	-	PUNCT
fnp-5377	216	11	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	216	12	aciduria	aciduria	NOUN
fnp-5377	216	13	.	.	PUNCT
fnp-5377	217	1	acta	acta	PROPN
fnp-5377	217	2	neurologica	neurologica	PROPN
fnp-5377	217	3	belgica	belgica	PROPN
fnp-5377	217	4	115	115	NUM
fnp-5377	217	5	,	,	PUNCT
fnp-5377	217	6	749	749	NUM
fnp-5377	217	7	-	-	SYM
fnp-5377	217	8	751	751	NUM
fnp-5377	217	9	(	(	PUNCT
fnp-5377	217	10	2015	2015	NUM
fnp-5377	217	11	)	)	PUNCT
fnp-5377	217	12	.	.	PUNCT
fnp-5377	218	1	https://doi.org/10.1007/s13760-015-0489-x	https://doi.org/10.1007/s13760-015-0489-x	PROPN
fnp-5377	218	2	26	26	NUM
fnp-5377	218	3	.	.	PUNCT
fnp-5377	219	1	dang	dang	PROPN
fnp-5377	219	2	l	l	NOUN
fnp-5377	219	3	,	,	PUNCT
fnp-5377	219	4	et	et	PROPN
fnp-5377	219	5	al	al	PROPN
fnp-5377	219	6	.	.	PUNCT
fnp-5377	220	1	cancer	cancer	NOUN
fnp-5377	220	2	-	-	PUNCT
fnp-5377	220	3	associated	associate	VERB
fnp-5377	220	4	idh1	idh1	NOUN
fnp-5377	220	5	mutations	mutation	NOUN
fnp-5377	220	6	produce	produce	VERB
fnp-5377	220	7	2	2	NUM
fnp-5377	220	8	-	-	PUNCT
fnp-5377	220	9	hydroxyglutarate	hydroxyglutarate	NOUN
fnp-5377	220	10	.	.	PUNCT
fnp-5377	221	1	nature	nature	PROPN
fnp-5377	221	2	462	462	NUM
fnp-5377	221	3	,	,	PUNCT
fnp-5377	221	4	739	739	NUM
fnp-5377	221	5	-	-	SYM
fnp-5377	221	6	744	744	NUM
fnp-5377	221	7	(	(	PUNCT
fnp-5377	221	8	2009	2009	NUM
fnp-5377	221	9	)	)	PUNCT
fnp-5377	221	10	.	.	PUNCT
fnp-5377	222	1	https://doi.org/10.1038/nature08617	https://doi.org/10.1038/nature08617	PROPN
fnp-5377	222	2	27	27	NUM
fnp-5377	222	3	.	.	PUNCT
fnp-5377	223	1	pirozzi	pirozzi	PROPN
fnp-5377	223	2	cj	cj	PROPN
fnp-5377	223	3	,	,	PUNCT
fnp-5377	223	4	yan	yan	PROPN
fnp-5377	223	5	h.	h.	PROPN
fnp-5377	224	1	the	the	DET
fnp-5377	224	2	implications	implication	NOUN
fnp-5377	224	3	of	of	ADP
fnp-5377	224	4	idh	idh	NOUN
fnp-5377	224	5	mutations	mutation	NOUN
fnp-5377	224	6	for	for	ADP
fnp-5377	224	7	cancer	cancer	NOUN
fnp-5377	224	8	development	development	NOUN
fnp-5377	224	9	and	and	CCONJ
fnp-5377	224	10	therapy	therapy	NOUN
fnp-5377	224	11	.	.	PUNCT
fnp-5377	225	1	nature	nature	NOUN
fnp-5377	225	2	reviews	review	VERB
fnp-5377	225	3	clinical	clinical	ADJ
fnp-5377	225	4	oncology	oncology	NOUN
fnp-5377	225	5	18	18	NUM
fnp-5377	225	6	,	,	PUNCT
fnp-5377	225	7	645	645	NUM
fnp-5377	225	8	-	-	SYM
fnp-5377	225	9	661	661	NUM
fnp-5377	225	10	(	(	PUNCT
fnp-5377	225	11	2021	2021	NUM
fnp-5377	225	12	)	)	PUNCT
fnp-5377	225	13	.	.	PUNCT
fnp-5377	226	1	https://doi.org/10.1038/s41571-021-00521-0	https://doi.org/10.1038/s41571-021-00521-0	NUM
fnp-5377	226	2	28	28	NUM
fnp-5377	226	3	.	.	PUNCT
fnp-5377	227	1	kranendijk	kranendijk	PROPN
fnp-5377	227	2	m	m	PROPN
fnp-5377	227	3	,	,	PUNCT
fnp-5377	227	4	struys	struys	PROPN
fnp-5377	227	5	ea	ea	PROPN
fnp-5377	227	6	,	,	PUNCT
fnp-5377	227	7	salomons	salomons	PROPN
fnp-5377	227	8	gs	gs	PROPN
fnp-5377	227	9	,	,	PUNCT
fnp-5377	227	10	van	van	PROPN
fnp-5377	227	11	der	der	PROPN
fnp-5377	227	12	knaap	knaap	PROPN
fnp-5377	227	13	ms	ms	PROPN
fnp-5377	227	14	,	,	PUNCT
fnp-5377	227	15	jakobs	jakobs	PROPN
fnp-5377	227	16	c.	c.	PROPN
fnp-5377	227	17	progress	progress	NOUN
fnp-5377	227	18	in	in	ADP
fnp-5377	227	19	understanding	understand	VERB
fnp-5377	227	20	2	2	NUM
fnp-5377	227	21	-	-	PUNCT
fnp-5377	227	22	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	227	23	acidurias	aciduria	NOUN
fnp-5377	227	24	.	.	PUNCT
fnp-5377	228	1	j	j	PROPN
fnp-5377	228	2	inherit	inherit	VERB
fnp-5377	228	3	metab	metab	PROPN
fnp-5377	228	4	dis	dis	PROPN
fnp-5377	228	5	35	35	NUM
fnp-5377	228	6	,	,	PUNCT
fnp-5377	228	7	571	571	NUM
fnp-5377	228	8	-	-	SYM
fnp-5377	228	9	587	587	NUM
fnp-5377	228	10	(	(	PUNCT
fnp-5377	228	11	2012	2012	NUM
fnp-5377	228	12	)	)	PUNCT
fnp-5377	228	13	.	.	PUNCT
fnp-5377	229	1	https://doi.org/10.1007/s10545-012-9462-5	https://doi.org/10.1007/s10545-012-9462-5	NUM
fnp-5377	229	2	29	29	NUM
fnp-5377	229	3	.	.	PUNCT
fnp-5377	230	1	kranendijk	kranendijk	PROPN
fnp-5377	230	2	m	m	PROPN
fnp-5377	230	3	,	,	PUNCT
fnp-5377	230	4	et	et	PROPN
fnp-5377	230	5	al	al	PROPN
fnp-5377	230	6	.	.	PROPN
fnp-5377	230	7	evidence	evidence	NOUN
fnp-5377	230	8	for	for	ADP
fnp-5377	230	9	genetic	genetic	ADJ
fnp-5377	230	10	heterogeneity	heterogeneity	NOUN
fnp-5377	230	11	in	in	ADP
fnp-5377	230	12	d-2	d-2	NOUN
fnp-5377	230	13	-	-	PUNCT
fnp-5377	230	14	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	230	15	aciduria	aciduria	NOUN
fnp-5377	230	16	.	.	PUNCT
fnp-5377	231	1	hum	hum	PROPN
fnp-5377	231	2	mutat	mutat	PROPN
fnp-5377	231	3	31	31	NUM
fnp-5377	231	4	,	,	PUNCT
fnp-5377	231	5	279	279	NUM
fnp-5377	231	6	-	-	SYM
fnp-5377	231	7	283	283	NUM
fnp-5377	231	8	(	(	PUNCT
fnp-5377	231	9	2010	2010	NUM
fnp-5377	231	10	)	)	PUNCT
fnp-5377	231	11	.	.	PUNCT
fnp-5377	232	1	https://doi.org/10.1002/humu.21186	https://doi.org/10.1002/humu.21186	ADJ
fnp-5377	232	2	30	30	NUM
fnp-5377	232	3	.	.	PUNCT
fnp-5377	233	1	wickenhagen	wickenhagen	PROPN
fnp-5377	233	2	wv	wv	PROPN
fnp-5377	233	3	,	,	PUNCT
fnp-5377	233	4	salomons	salomon	VERB
fnp-5377	233	5	gs	gs	PROPN
fnp-5377	233	6	,	,	PUNCT
fnp-5377	233	7	gibson	gibson	PROPN
fnp-5377	233	8	km	km	PROPN
fnp-5377	233	9	,	,	PUNCT
fnp-5377	233	10	jakobs	jakobs	PROPN
fnp-5377	233	11	c	c	PROPN
fnp-5377	233	12	,	,	PUNCT
fnp-5377	233	13	struys	struys	PROPN
fnp-5377	233	14	ea	ea	PROPN
fnp-5377	233	15	.	.	PUNCT
fnp-5377	233	16	measurement	measurement	NOUN
fnp-5377	233	17	of	of	ADP
fnp-5377	233	18	d-2	d-2	NOUN
fnp-5377	233	19	-	-	PUNCT
fnp-5377	233	20	hydroxyglutarate	hydroxyglutarate	NOUN
fnp-5377	233	21	dehydrogenase	dehydrogenase	NOUN
fnp-5377	233	22	activity	activity	NOUN
fnp-5377	233	23	in	in	ADP
fnp-5377	233	24	cell	cell	NOUN
fnp-5377	233	25	homogenates	homogenate	NOUN
fnp-5377	233	26	derived	derive	VERB
fnp-5377	233	27	from	from	ADP
fnp-5377	233	28	d-2	d-2	NOUN
fnp-5377	233	29	-	-	PUNCT
fnp-5377	233	30	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	233	31	aciduria	aciduria	NOUN
fnp-5377	233	32	patients	patient	NOUN
fnp-5377	233	33	.	.	PUNCT
fnp-5377	234	1	j	j	PROPN
fnp-5377	234	2	inherit	inherit	VERB
fnp-5377	234	3	metab	metab	PROPN
fnp-5377	234	4	dis	dis	PROPN
fnp-5377	234	5	32	32	NUM
fnp-5377	234	6	,	,	PUNCT
fnp-5377	234	7	264	264	NUM
fnp-5377	234	8	-	-	SYM
fnp-5377	234	9	268	268	NUM
fnp-5377	234	10	(	(	PUNCT
fnp-5377	234	11	2009	2009	NUM
fnp-5377	234	12	)	)	PUNCT
fnp-5377	234	13	.	.	PUNCT
fnp-5377	235	1	https://doi.org/10.1007/s10545-009-1104-1	https://doi.org/10.1007/s10545-009-1104-1	NOUN
fnp-5377	235	2	31	31	NUM
fnp-5377	235	3	.	.	PUNCT
fnp-5377	236	1	losman	losman	PROPN
fnp-5377	236	2	ja	ja	PROPN
fnp-5377	236	3	,	,	PUNCT
fnp-5377	236	4	kaelin	kaelin	PROPN
fnp-5377	236	5	wg	wg	PROPN
fnp-5377	236	6	,	,	PUNCT
fnp-5377	236	7	jr	jr	PROPN
fnp-5377	236	8	.	.	PUNCT
fnp-5377	237	1	what	what	PRON
fnp-5377	237	2	a	a	DET
fnp-5377	237	3	difference	difference	NOUN
fnp-5377	237	4	a	a	DET
fnp-5377	237	5	hydroxyl	hydroxyl	NOUN
fnp-5377	237	6	makes	make	VERB
fnp-5377	237	7	:	:	PUNCT
fnp-5377	237	8	mutant	mutant	ADJ
fnp-5377	237	9	idh	idh	NOUN
fnp-5377	237	10	,	,	PUNCT
fnp-5377	237	11	(	(	PUNCT
fnp-5377	237	12	r)-2	r)-2	NOUN
fnp-5377	237	13	-	-	PUNCT
fnp-5377	237	14	hydroxyglutarate	hydroxyglutarate	NOUN
fnp-5377	237	15	,	,	PUNCT
fnp-5377	237	16	and	and	CCONJ
fnp-5377	237	17	cancer	cancer	NOUN
fnp-5377	237	18	.	.	PUNCT
fnp-5377	238	1	genes	gene	NOUN
fnp-5377	238	2	dev	dev	PROPN
fnp-5377	238	3	27	27	NUM
fnp-5377	238	4	,	,	PUNCT
fnp-5377	238	5	836	836	NUM
fnp-5377	238	6	-	-	SYM
fnp-5377	238	7	852	852	NUM
fnp-5377	238	8	(	(	PUNCT
fnp-5377	238	9	2013	2013	NUM
fnp-5377	238	10	)	)	PUNCT
fnp-5377	238	11	.	.	PUNCT
fnp-5377	239	1	https://doi.org/10.1101/gad.217406.113	https://doi.org/10.1101/gad.217406.113	PROPN
fnp-5377	239	2	32	32	NUM
fnp-5377	239	3	.	.	PUNCT
fnp-5377	240	1	tan	tan	PROPN
fnp-5377	240	2	ap	ap	PROPN
fnp-5377	240	3	,	,	PUNCT
fnp-5377	240	4	mankad	mankad	PROPN
fnp-5377	240	5	k.	k.	PROPN
fnp-5377	240	6	intraventricular	intraventricular	ADJ
fnp-5377	240	7	glioblastoma	glioblastoma	NOUN
fnp-5377	240	8	multiforme	multiforme	VERB
fnp-5377	240	9	in	in	ADP
fnp-5377	240	10	a	a	DET
fnp-5377	240	11	child	child	NOUN
fnp-5377	240	12	with	with	ADP
fnp-5377	240	13	l2	l2	NOUN
fnp-5377	240	14	-	-	PUNCT
fnp-5377	240	15	hydroxyglutaric	hydroxyglutaric	NOUN
fnp-5377	240	16	aciduria	aciduria	NOUN
fnp-5377	240	17	.	.	PUNCT
fnp-5377	241	1	world	world	NOUN
fnp-5377	241	2	neurosurgery	neurosurgery	NOUN
fnp-5377	241	3	110	110	NUM
fnp-5377	241	4	,	,	PUNCT
fnp-5377	241	5	288	288	NUM
fnp-5377	241	6	-	-	SYM
fnp-5377	241	7	290	290	NUM
fnp-5377	241	8	(	(	PUNCT
fnp-5377	241	9	2018	2018	NUM
fnp-5377	241	10	)	)	PUNCT
fnp-5377	241	11	.	.	PUNCT
fnp-5377	242	1	https://doi.org/10.1016/j.wneu.2017.11.106	https://doi.org/10.1016/j.wneu.2017.11.106	NOUN
fnp-5377	242	2	33	33	NUM
fnp-5377	242	3	.	.	PUNCT
fnp-5377	243	1	de	de	PROPN
fnp-5377	243	2	souza	souza	PROPN
fnp-5377	243	3	cf	cf	PROPN
fnp-5377	243	4	,	,	PUNCT
fnp-5377	243	5	et	et	PROPN
fnp-5377	243	6	al	al	PROPN
fnp-5377	243	7	.	.	PUNCT
fnp-5377	244	1	a	a	DET
fnp-5377	244	2	distinct	distinct	ADJ
fnp-5377	244	3	dna	dna	PROPN
fnp-5377	244	4	methylation	methylation	NOUN
fnp-5377	244	5	shift	shift	NOUN
fnp-5377	244	6	in	in	ADP
fnp-5377	244	7	a	a	DET
fnp-5377	244	8	subset	subset	NOUN
fnp-5377	244	9	of	of	ADP
fnp-5377	244	10	glioma	glioma	NOUN
fnp-5377	244	11	cpg	cpg	PROPN
fnp-5377	244	12	island	island	NOUN
fnp-5377	244	13	methylator	methylator	PROPN
fnp-5377	244	14	phenotypes	phenotype	NOUN
fnp-5377	244	15	during	during	ADP
fnp-5377	244	16	tumor	tumor	NOUN
fnp-5377	244	17	recurrence	recurrence	NOUN
fnp-5377	244	18	.	.	PUNCT
fnp-5377	245	1	cell	cell	NOUN
fnp-5377	245	2	rep	rep	PROPN
fnp-5377	245	3	23	23	NUM
fnp-5377	245	4	,	,	PUNCT
fnp-5377	245	5	637	637	NUM
fnp-5377	245	6	-	-	SYM
fnp-5377	245	7	651	651	NUM
fnp-5377	245	8	(	(	PUNCT
fnp-5377	245	9	2018	2018	NUM
fnp-5377	245	10	)	)	PUNCT
fnp-5377	245	11	.	.	PUNCT
fnp-5377	246	1	https://doi.org/10.1016/j.celrep.2018.03.107	https://doi.org/10.1016/j.celrep.2018.03.107	NOUN
fnp-5377	246	2	34	34	NUM
fnp-5377	246	3	.	.	PUNCT
fnp-5377	247	1	ceccarelli	ceccarelli	PROPN
fnp-5377	247	2	m	m	PROPN
fnp-5377	247	3	,	,	PUNCT
fnp-5377	247	4	et	et	PROPN
fnp-5377	247	5	al	al	PROPN
fnp-5377	247	6	.	.	PROPN
fnp-5377	248	1	molecular	molecular	ADJ
fnp-5377	248	2	profiling	profiling	NOUN
fnp-5377	248	3	reveals	reveal	VERB
fnp-5377	248	4	biologically	biologically	ADV
fnp-5377	248	5	discrete	discrete	ADJ
fnp-5377	248	6	subsets	subset	NOUN
fnp-5377	248	7	and	and	CCONJ
fnp-5377	248	8	pathways	pathway	NOUN
fnp-5377	248	9	of	of	ADP
fnp-5377	248	10	progression	progression	NOUN
fnp-5377	248	11	in	in	ADP
fnp-5377	248	12	diffuse	diffuse	PROPN
fnp-5377	248	13	glioma	glioma	NOUN
fnp-5377	248	14	.	.	PUNCT
fnp-5377	249	1	cell	cell	NOUN
fnp-5377	249	2	164	164	NUM
fnp-5377	249	3	,	,	PUNCT
fnp-5377	249	4	550	550	NUM
fnp-5377	249	5	-	-	SYM
fnp-5377	249	6	563	563	NUM
fnp-5377	249	7	(	(	PUNCT
fnp-5377	249	8	2016	2016	NUM
fnp-5377	249	9	)	)	PUNCT
fnp-5377	249	10	.	.	PUNCT
fnp-5377	250	1	https://doi.org/10.1016/j.cell.2015.12.028	https://doi.org/10.1016/j.cell.2015.12.028	ADJ
fnp-5377	250	2	35	35	NUM
fnp-5377	250	3	.	.	PUNCT
fnp-5377	251	1	wilcken	wilcken	PROPN
fnp-5377	251	2	b	b	PROPN
fnp-5377	251	3	,	,	PUNCT
fnp-5377	251	4	pitt	pitt	PROPN
fnp-5377	251	5	j	j	PROPN
fnp-5377	251	6	,	,	PUNCT
fnp-5377	251	7	heath	heath	PROPN
fnp-5377	251	8	d	d	PROPN
fnp-5377	251	9	,	,	PUNCT
fnp-5377	251	10	walsh	walsh	PROPN
fnp-5377	251	11	p	p	PROPN
fnp-5377	251	12	,	,	PUNCT
fnp-5377	251	13	wilson	wilson	PROPN
fnp-5377	251	14	g	g	PROPN
fnp-5377	251	15	,	,	PUNCT
fnp-5377	251	16	buchanan	buchanan	PROPN
fnp-5377	251	17	n.	n.	PROPN
fnp-5377	251	18	l-2	l-2	PROPN
fnp-5377	251	19	-	-	PUNCT
fnp-5377	251	20	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	251	21	aciduria	aciduria	NOUN
fnp-5377	251	22	:	:	PUNCT
fnp-5377	251	23	three	three	NUM
fnp-5377	251	24	australian	australian	ADJ
fnp-5377	251	25	cases	case	NOUN
fnp-5377	251	26	.	.	PUNCT
fnp-5377	252	1	journal	journal	NOUN
fnp-5377	252	2	of	of	ADP
fnp-5377	252	3	inherited	inherit	VERB
fnp-5377	252	4	metabolic	metabolic	NOUN
fnp-5377	252	5	disease	disease	NOUN
fnp-5377	252	6	16	16	NUM
fnp-5377	252	7	,	,	PUNCT
fnp-5377	252	8	501	501	NUM
fnp-5377	252	9	-	-	SYM
fnp-5377	252	10	504	504	NUM
fnp-5377	252	11	(	(	PUNCT
fnp-5377	252	12	1993	1993	NUM
fnp-5377	252	13	)	)	PUNCT
fnp-5377	252	14	.	.	PUNCT
fnp-5377	253	1	https://doi.org/10.1007/bf00711665	https://doi.org/10.1007/bf00711665	ADJ
fnp-5377	253	2	36	36	NUM
fnp-5377	253	3	.	.	PUNCT
fnp-5377	254	1	barbot	barbot	PROPN
fnp-5377	254	2	c	c	PROPN
fnp-5377	254	3	,	,	PUNCT
fnp-5377	254	4	et	et	PROPN
fnp-5377	254	5	al	al	PROPN
fnp-5377	254	6	.	.	PUNCT
fnp-5377	255	1	l-2	l-2	PROPN
fnp-5377	255	2	-	-	PUNCT
fnp-5377	255	3	hydroxyglutaric	hydroxyglutaric	NOUN
fnp-5377	255	4	aciduria	aciduria	NOUN
fnp-5377	255	5	:	:	PUNCT
fnp-5377	255	6	clinical	clinical	ADJ
fnp-5377	255	7	,	,	PUNCT
fnp-5377	255	8	biochemical	biochemical	ADJ
fnp-5377	255	9	and	and	CCONJ
fnp-5377	255	10	magnetic	magnetic	ADJ
fnp-5377	255	11	resonance	resonance	NOUN
fnp-5377	255	12	imaging	imaging	NOUN
fnp-5377	255	13	in	in	ADP
fnp-5377	255	14	six	six	NUM
fnp-5377	255	15	portuguese	portuguese	ADJ
fnp-5377	255	16	pediatric	pediatric	ADJ
fnp-5377	255	17	patients	patient	NOUN
fnp-5377	255	18	.	.	PUNCT
fnp-5377	256	1	brain	brain	PROPN
fnp-5377	256	2	&	&	CCONJ
fnp-5377	256	3	development	development	PROPN
fnp-5377	256	4	19	19	NUM
fnp-5377	256	5	,	,	PUNCT
fnp-5377	256	6	268	268	NUM
fnp-5377	256	7	-	-	SYM
fnp-5377	256	8	273	273	NUM
fnp-5377	256	9	(	(	PUNCT
fnp-5377	256	10	1997	1997	NUM
fnp-5377	256	11	)	)	PUNCT
fnp-5377	256	12	.	.	PUNCT
fnp-5377	257	1	https://doi.org/10.1016/s0387-7604(97)00574-3	https://doi.org/10.1016/s0387-7604(97)00574-3	ADJ
fnp-5377	257	2	37	37	NUM
fnp-5377	257	3	.	.	PUNCT
fnp-5377	258	1	wanders	wander	VERB
fnp-5377	258	2	rj	rj	PROPN
fnp-5377	258	3	,	,	PUNCT
fnp-5377	258	4	et	et	PROPN
fnp-5377	258	5	al	al	PROPN
fnp-5377	258	6	.	.	PUNCT
fnp-5377	259	1	l-2	l-2	PROPN
fnp-5377	259	2	-	-	PUNCT
fnp-5377	259	3	hydroxyglutaric	hydroxyglutaric	NOUN
fnp-5377	259	4	aciduria	aciduria	NOUN
fnp-5377	259	5	:	:	PUNCT
fnp-5377	259	6	normal	normal	ADJ
fnp-5377	259	7	l-2	l-2	PROPN
fnp-5377	259	8	-	-	PUNCT
fnp-5377	259	9	hydroxyglutarate	hydroxyglutarate	PROPN
fnp-5377	259	10	dehydrogenase	dehydrogenase	NOUN
fnp-5377	259	11	activity	activity	NOUN
fnp-5377	259	12	in	in	ADP
fnp-5377	259	13	liver	liver	NOUN
fnp-5377	259	14	from	from	ADP
fnp-5377	259	15	two	two	NUM
fnp-5377	259	16	new	new	ADJ
fnp-5377	259	17	patients	patient	NOUN
fnp-5377	259	18	.	.	PUNCT
fnp-5377	260	1	journal	journal	NOUN
fnp-5377	260	2	of	of	ADP
fnp-5377	260	3	inherited	inherit	VERB
fnp-5377	260	4	metabolic	metabolic	NOUN
fnp-5377	260	5	disease	disease	NOUN
fnp-5377	260	6	20	20	NUM
fnp-5377	260	7	,	,	PUNCT
fnp-5377	260	8	725	725	NUM
fnp-5377	260	9	-	-	SYM
fnp-5377	260	10	726	726	NUM
fnp-5377	260	11	(	(	PUNCT
fnp-5377	260	12	1997	1997	NUM
fnp-5377	260	13	)	)	PUNCT
fnp-5377	260	14	.	.	PUNCT
fnp-5377	261	1	https://doi.org/10.1023/a:1005355316599	https://doi.org/10.1023/a:1005355316599	VERB
fnp-5377	261	2	38	38	NUM
fnp-5377	261	3	.	.	PUNCT
fnp-5377	262	1	ozisik	ozisik	PROPN
fnp-5377	262	2	pa	pa	PROPN
fnp-5377	262	3	,	,	PUNCT
fnp-5377	262	4	akalan	akalan	VERB
fnp-5377	262	5	n	n	PRON
fnp-5377	262	6	,	,	PUNCT
fnp-5377	262	7	palaoglu	palaoglu	NOUN
fnp-5377	262	8	s	s	PROPN
fnp-5377	262	9	,	,	PUNCT
fnp-5377	262	10	topcu	topcu	ADJ
fnp-5377	262	11	m.	m.	NOUN
fnp-5377	262	12	medulloblastoma	medulloblastoma	NOUN
fnp-5377	262	13	in	in	ADP
fnp-5377	262	14	a	a	DET
fnp-5377	262	15	child	child	NOUN
fnp-5377	262	16	with	with	ADP
fnp-5377	262	17	the	the	DET
fnp-5377	262	18	metabolic	metabolic	NOUN
fnp-5377	262	19	disease	disease	NOUN
fnp-5377	262	20	l-2	l-2	PROPN
fnp-5377	262	21	-	-	PUNCT
fnp-5377	262	22	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	262	23	aciduria	aciduria	NOUN
fnp-5377	262	24	.	.	PUNCT
fnp-5377	263	1	pediatric	pediatric	ADJ
fnp-5377	263	2	neurosurgery	neurosurgery	NOUN
fnp-5377	263	3	37	37	NUM
fnp-5377	263	4	,	,	PUNCT
fnp-5377	263	5	22	22	NUM
fnp-5377	263	6	-	-	SYM
fnp-5377	263	7	26	26	NUM
fnp-5377	263	8	(	(	PUNCT
fnp-5377	263	9	2002	2002	NUM
fnp-5377	263	10	)	)	PUNCT
fnp-5377	263	11	.	.	PUNCT
fnp-5377	264	1	https://doi.org/10.1159/000065097	https://doi.org/10.1159/000065097	PUNCT
fnp-5377	265	1	39	39	NUM
fnp-5377	265	2	.	.	PUNCT
fnp-5377	266	1	topcu	topcu	PROPN
fnp-5377	266	2	m	m	PROPN
fnp-5377	266	3	,	,	PUNCT
fnp-5377	266	4	et	et	PROPN
fnp-5377	266	5	al	al	PROPN
fnp-5377	266	6	.	.	PUNCT
fnp-5377	267	1	l-2	l-2	PROPN
fnp-5377	267	2	-	-	PUNCT
fnp-5377	267	3	hydroxyglutaric	hydroxyglutaric	NOUN
fnp-5377	267	4	aciduria	aciduria	NOUN
fnp-5377	267	5	:	:	PUNCT
fnp-5377	267	6	a	a	DET
fnp-5377	267	7	report	report	NOUN
fnp-5377	267	8	of	of	ADP
fnp-5377	267	9	29	29	NUM
fnp-5377	267	10	patients	patient	NOUN
fnp-5377	267	11	.	.	PUNCT
fnp-5377	268	1	the	the	DET
fnp-5377	268	2	turkish	turkish	ADJ
fnp-5377	268	3	journal	journal	NOUN
fnp-5377	268	4	of	of	ADP
fnp-5377	268	5	pediatrics	pediatric	NOUN
fnp-5377	268	6	47	47	NUM
fnp-5377	268	7	,	,	PUNCT
fnp-5377	268	8	1	1	NUM
fnp-5377	268	9	-	-	SYM
fnp-5377	268	10	7	7	NUM
fnp-5377	268	11	(	(	PUNCT
fnp-5377	268	12	2005	2005	NUM
fnp-5377	268	13	)	)	PUNCT
fnp-5377	268	14	.	.	PUNCT
fnp-5377	269	1	40	40	NUM
fnp-5377	269	2	.	.	PUNCT
fnp-5377	270	1	vilarinho	vilarinho	PROPN
fnp-5377	270	2	l	l	PROPN
fnp-5377	270	3	,	,	PUNCT
fnp-5377	270	4	et	et	PROPN
fnp-5377	270	5	al	al	PROPN
fnp-5377	270	6	.	.	PROPN
fnp-5377	270	7	novel	novel	ADJ
fnp-5377	270	8	l2hgdh	l2hgdh	ADJ
fnp-5377	270	9	mutations	mutation	NOUN
fnp-5377	270	10	in	in	ADP
fnp-5377	270	11	21	21	NUM
fnp-5377	270	12	patients	patient	NOUN
fnp-5377	270	13	with	with	ADP
fnp-5377	270	14	l-2	l-2	PROPN
fnp-5377	270	15	-	-	PUNCT
fnp-5377	270	16	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	270	17	aciduria	aciduria	NOUN
fnp-5377	270	18	of	of	ADP
fnp-5377	270	19	portuguese	portuguese	ADJ
fnp-5377	270	20	origin	origin	NOUN
fnp-5377	270	21	.	.	PUNCT
fnp-5377	271	1	human	human	ADJ
fnp-5377	271	2	mutation	mutation	NOUN
fnp-5377	271	3	26	26	NUM
fnp-5377	271	4	,	,	PUNCT
fnp-5377	271	5	395	395	NUM
fnp-5377	271	6	-	-	SYM
fnp-5377	271	7	396	396	NUM
fnp-5377	271	8	(	(	PUNCT
fnp-5377	271	9	2005	2005	NUM
fnp-5377	271	10	)	)	PUNCT
fnp-5377	271	11	.	.	PUNCT
fnp-5377	272	1	https://doi.org/10.1002/humu.9373	https://doi.org/10.1002/humu.9373	NOUN
fnp-5377	272	2	41	41	NUM
fnp-5377	272	3	.	.	PUNCT
fnp-5377	273	1	haliloglu	haliloglu	PROPN
fnp-5377	273	2	g	g	PROPN
fnp-5377	273	3	,	,	PUNCT
fnp-5377	273	4	et	et	PROPN
fnp-5377	273	5	al	al	PROPN
fnp-5377	273	6	.	.	PUNCT
fnp-5377	274	1	l-2	l-2	PROPN
fnp-5377	274	2	-	-	PUNCT
fnp-5377	274	3	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	274	4	aciduria	aciduria	NOUN
fnp-5377	274	5	and	and	CCONJ
fnp-5377	274	6	brain	brain	NOUN
fnp-5377	274	7	tumors	tumor	NOUN
fnp-5377	274	8	in	in	ADP
fnp-5377	274	9	children	child	NOUN
fnp-5377	274	10	with	with	ADP
fnp-5377	274	11	mutations	mutation	NOUN
fnp-5377	274	12	in	in	ADP
fnp-5377	274	13	the	the	DET
fnp-5377	274	14	l2hgdh	l2hgdh	ADJ
fnp-5377	274	15	gene	gene	NOUN
fnp-5377	274	16	:	:	PUNCT
fnp-5377	274	17	neuroimaging	neuroimage	VERB
fnp-5377	274	18	findings	finding	NOUN
fnp-5377	274	19	.	.	PUNCT
fnp-5377	275	1	neuropediatrics	neuropediatric	NOUN
fnp-5377	275	2	39	39	NUM
fnp-5377	275	3	,	,	PUNCT
fnp-5377	275	4	119	119	NUM
fnp-5377	275	5	-	-	SYM
fnp-5377	275	6	122	122	NUM
fnp-5377	275	7	(	(	PUNCT
fnp-5377	275	8	2008	2008	NUM
fnp-5377	275	9	)	)	PUNCT
fnp-5377	275	10	.	.	PUNCT
fnp-5377	276	1	https://doi.org/10.1055/s-2008-1081217	https://doi.org/10.1055/s-2008-1081217	NOUN
fnp-5377	276	2	42	42	NUM
fnp-5377	276	3	.	.	PUNCT
fnp-5377	277	1	aghili	aghili	PROPN
fnp-5377	277	2	m	m	PROPN
fnp-5377	277	3	,	,	PUNCT
fnp-5377	277	4	zahedi	zahedi	PROPN
fnp-5377	277	5	f	f	PROPN
fnp-5377	277	6	,	,	PUNCT
fnp-5377	277	7	rafiee	rafiee	PROPN
fnp-5377	277	8	e.	e.	PROPN
fnp-5377	277	9	hydroxyglutaric	hydroxyglutaric	PROPN
fnp-5377	277	10	aciduria	aciduria	NOUN
fnp-5377	277	11	and	and	CCONJ
fnp-5377	277	12	malignant	malignant	ADJ
fnp-5377	277	13	brain	brain	NOUN
fnp-5377	277	14	tumor	tumor	NOUN
fnp-5377	277	15	:	:	PUNCT
fnp-5377	277	16	a	a	DET
fnp-5377	277	17	case	case	NOUN
fnp-5377	277	18	report	report	NOUN
fnp-5377	277	19	and	and	CCONJ
fnp-5377	277	20	literature	literature	PROPN
fnp-5377	277	21	review	review	PROPN
fnp-5377	277	22	.	.	PUNCT
fnp-5377	278	1	journal	journal	PROPN
fnp-5377	278	2	of	of	ADP
fnp-5377	278	3	neuro	neuro	NOUN
fnp-5377	278	4	-	-	PUNCT
fnp-5377	278	5	oncology	oncology	NOUN
fnp-5377	278	6	91	91	NUM
fnp-5377	278	7	,	,	PUNCT
fnp-5377	278	8	233	233	NUM
fnp-5377	278	9	-	-	SYM
fnp-5377	278	10	236	236	NUM
fnp-5377	278	11	(	(	PUNCT
fnp-5377	278	12	2009	2009	NUM
fnp-5377	278	13	)	)	PUNCT
fnp-5377	278	14	.	.	PUNCT
fnp-5377	279	1	https://doi.org/10.1007/s11060-008-9706-2	https://doi.org/10.1007/s11060-008-9706-2	NUM
fnp-5377	280	1	43	43	NUM
fnp-5377	280	2	.	.	PUNCT
fnp-5377	281	1	i̇brahim	i̇brahim	PRON
fnp-5377	282	1	i̇nan	i̇nan	ADV
fnp-5377	282	2	ba	ba	PROPN
fnp-5377	282	3	,	,	PUNCT
fnp-5377	282	4	ahmet	ahmet	PROPN
fnp-5377	282	5	aslan	aslan	PROPN
fnp-5377	282	6	,	,	PUNCT
fnp-5377	282	7	begümhan	begümhan	VERB
fnp-5377	282	8	baysal	baysal	PROPN
fnp-5377	282	9	,	,	PUNCT
fnp-5377	282	10	ali	ali	PROPN
fnp-5377	282	11	yıkılmaz	yıkılmaz	PROPN
fnp-5377	282	12	.	.	PUNCT
fnp-5377	283	1	l-2	l-2	PROPN
fnp-5377	283	2	hydroxyglutaric	hydroxyglutaric	ADJ
fnp-5377	283	3	aciduria	aciduria	NOUN
fnp-5377	283	4	and	and	CCONJ
fnp-5377	283	5	anaplastic	anaplastic	ADJ
fnp-5377	283	6	oligodendroglioma	oligodendroglioma	NOUN
fnp-5377	283	7	:	:	PUNCT
fnp-5377	283	8	a	a	DET
fnp-5377	283	9	rare	rare	ADJ
fnp-5377	283	10	association	association	NOUN
fnp-5377	283	11	.	.	PUNCT
fnp-5377	284	1	istanbul	istanbul	PROPN
fnp-5377	284	2	medical	medical	PROPN
fnp-5377	284	3	journal	journal	PROPN
fnp-5377	284	4	19	19	NUM
fnp-5377	284	5	,	,	PUNCT
fnp-5377	284	6	52	52	NUM
fnp-5377	284	7	-	-	SYM
fnp-5377	284	8	55	55	NUM
fnp-5377	284	9	(	(	PUNCT
fnp-5377	284	10	2018	2018	NUM
fnp-5377	284	11	)	)	PUNCT
fnp-5377	284	12	.	.	PUNCT
fnp-5377	285	1	https://doi.org/10.1212/01.wnl.0000125335.21381.87	https://doi.org/10.1212/01.wnl.0000125335.21381.87	VERB