id	sid	tid	token	lemma	pos
fnp-6282	1	1	depletion	depletion	NOUN
fnp-6282	1	2	of	of	ADP
fnp-6282	1	3	nuclear	nuclear	ADJ
fnp-6282	1	4	cytoophidia	cytoophidia	PROPN
fnp-6282	1	5	in	in	ADP
fnp-6282	1	6	alzheimer	alzheimer	PROPN
fnp-6282	1	7	’s	’s	PART
fnp-6282	1	8	disease	disease	NOUN
fnp-6282	1	9	feel	feel	VERB
fnp-6282	1	10	free	free	ADJ
fnp-6282	1	11	to	to	PART
fnp-6282	1	12	add	add	VERB
fnp-6282	1	13	comments	comment	NOUN
fnp-6282	1	14	by	by	ADP
fnp-6282	1	15	clicking	click	VERB
fnp-6282	1	16	these	these	DET
fnp-6282	1	17	icons	icon	NOUN
fnp-6282	1	18	on	on	ADP
fnp-6282	1	19	the	the	DET
fnp-6282	1	20	sidebar	sidebar	NOUN
fnp-6282	1	21	free	free	ADJ
fnp-6282	1	22	neuropathology	neuropathology	NOUN
fnp-6282	1	23	6:8	6:8	NUM
fnp-6282	1	24	(	(	PUNCT
fnp-6282	1	25	2025	2025	NUM
fnp-6282	1	26	)	)	PUNCT
fnp-6282	1	27	original	original	ADJ
fnp-6282	1	28	paper	paper	NOUN
fnp-6282	1	29	depletion	depletion	NOUN
fnp-6282	1	30	of	of	ADP
fnp-6282	1	31	nuclear	nuclear	ADJ
fnp-6282	1	32	cytoophidia	cytoophidia	PROPN
fnp-6282	1	33	in	in	ADP
fnp-6282	1	34	alzheimer	alzheimer	PROPN
fnp-6282	1	35	’s	’s	PART
fnp-6282	1	36	disease	disease	NOUN
fnp-6282	1	37	alyona	alyona	PROPN
fnp-6282	1	38	ivanova	ivanova	PROPN
fnp-6282	1	39	1	1	NUM
fnp-6282	1	40	,	,	PUNCT
fnp-6282	1	41	david	david	PROPN
fnp-6282	1	42	g.	g.	PROPN
fnp-6282	1	43	munoz	munoz	PROPN
fnp-6282	1	44	2	2	NUM
fnp-6282	1	45	,	,	PUNCT
fnp-6282	1	46	john	john	PROPN
fnp-6282	1	47	woulfe	woulfe	VERB
fnp-6282	1	48	3,4	3,4	NUM
fnp-6282	1	49	university	university	NOUN
fnp-6282	1	50	of	of	ADP
fnp-6282	1	51	toronto	toronto	PROPN
fnp-6282	1	52	,	,	PUNCT
fnp-6282	1	53	toronto	toronto	PROPN
fnp-6282	1	54	,	,	PUNCT
fnp-6282	1	55	ontario	ontario	PROPN
fnp-6282	1	56	,	,	PUNCT
fnp-6282	1	57	canada	canada	PROPN
fnp-6282	1	58	department	department	PROPN
fnp-6282	1	59	of	of	ADP
fnp-6282	1	60	laboratory	laboratory	NOUN
fnp-6282	1	61	medicine	medicine	NOUN
fnp-6282	1	62	,	,	PUNCT
fnp-6282	1	63	st	st	PROPN
fnp-6282	1	64	.	.	PROPN
fnp-6282	1	65	michael	michael	PROPN
fnp-6282	1	66	’s	’s	PART
fnp-6282	1	67	hospital	hospital	NOUN
fnp-6282	1	68	,	,	PUNCT
fnp-6282	1	69	unity	unity	NOUN
fnp-6282	1	70	health	health	PROPN
fnp-6282	1	71	&	&	CCONJ
fnp-6282	1	72	department	department	PROPN
fnp-6282	1	73	of	of	ADP
fnp-6282	1	74	laboratory	laboratory	NOUN
fnp-6282	1	75	medicine	medicine	NOUN
fnp-6282	1	76	and	and	CCONJ
fnp-6282	1	77	pathobiology	pathobiology	NOUN
fnp-6282	1	78	,	,	PUNCT
fnp-6282	1	79	university	university	PROPN
fnp-6282	1	80	of	of	ADP
fnp-6282	1	81	toronto	toronto	PROPN
fnp-6282	1	82	,	,	PUNCT
fnp-6282	1	83	toronto	toronto	PROPN
fnp-6282	1	84	,	,	PUNCT
fnp-6282	1	85	ontario	ontario	PROPN
fnp-6282	1	86	,	,	PUNCT
fnp-6282	1	87	canada	canada	PROPN
fnp-6282	1	88	department	department	PROPN
fnp-6282	1	89	of	of	ADP
fnp-6282	1	90	pathology	pathology	PROPN
fnp-6282	1	91	and	and	CCONJ
fnp-6282	1	92	laboratory	laboratory	NOUN
fnp-6282	1	93	medicine	medicine	NOUN
fnp-6282	1	94	,	,	PUNCT
fnp-6282	1	95	university	university	PROPN
fnp-6282	1	96	of	of	ADP
fnp-6282	1	97	ottawa	ottawa	PROPN
fnp-6282	1	98	,	,	PUNCT
fnp-6282	1	99	ottawa	ottawa	PROPN
fnp-6282	1	100	,	,	PUNCT
fnp-6282	1	101	ontario	ontario	PROPN
fnp-6282	1	102	,	,	PUNCT
fnp-6282	1	103	canada	canada	PROPN
fnp-6282	1	104	ottawa	ottawa	PROPN
fnp-6282	1	105	hospital	hospital	PROPN
fnp-6282	1	106	research	research	PROPN
fnp-6282	1	107	institute	institute	PROPN
fnp-6282	1	108	,	,	PUNCT
fnp-6282	1	109	ottawa	ottawa	PROPN
fnp-6282	1	110	,	,	PUNCT
fnp-6282	1	111	ontario	ontario	PROPN
fnp-6282	1	112	,	,	PUNCT
fnp-6282	1	113	canada	canada	PROPN
fnp-6282	1	114	corresponding	corresponding	PROPN
fnp-6282	1	115	author	author	NOUN
fnp-6282	1	116	:	:	PUNCT
fnp-6282	1	117	john	john	PROPN
fnp-6282	1	118	woulfe	woulfe	PROPN
fnp-6282	1	119	·	·	PUNCT
fnp-6282	1	120	department	department	PROPN
fnp-6282	1	121	of	of	ADP
fnp-6282	1	122	pathology	pathology	NOUN
fnp-6282	1	123	and	and	CCONJ
fnp-6282	1	124	laboratory	laboratory	NOUN
fnp-6282	1	125	medicine	medicine	NOUN
fnp-6282	1	126	·	·	PUNCT
fnp-6282	1	127	university	university	NOUN
fnp-6282	1	128	of	of	ADP
fnp-6282	1	129	ottawa	ottawa	PROPN
fnp-6282	1	130	·	·	PUNCT
fnp-6282	1	131	501	501	NUM
fnp-6282	1	132	smyth	smyth	NOUN
fnp-6282	1	133	road	road	NOUN
fnp-6282	1	134	·	·	PUNCT
fnp-6282	1	135	ottawa	ottawa	PROPN
fnp-6282	1	136	·	·	PUNCT
fnp-6282	1	137	ontario	ontario	PROPN
fnp-6282	1	138	·	·	PUNCT
fnp-6282	1	139	canada	canada	PROPN
fnp-6282	2	1	jwoulfe@toh.ca	jwoulfe@toh.ca	VERB
fnp-6282	2	2	additional	additional	ADJ
fnp-6282	2	3	resources	resource	NOUN
fnp-6282	2	4	and	and	CCONJ
fnp-6282	2	5	electronic	electronic	ADJ
fnp-6282	2	6	supplementary	supplementary	ADJ
fnp-6282	2	7	material	material	NOUN
fnp-6282	2	8	:	:	PUNCT
fnp-6282	2	9	supplementary	supplementary	ADJ
fnp-6282	2	10	table	table	NOUN
fnp-6282	2	11	 	 	SPACE
fnp-6282	2	12	1	1	NUM
fnp-6282	2	13	submitted	submit	VERB
fnp-6282	2	14	:	:	PUNCT
fnp-6282	2	15	28	28	NUM
fnp-6282	2	16	january	january	PROPN
fnp-6282	2	17	2025	2025	NUM
fnp-6282	2	18	accepted	accept	VERB
fnp-6282	2	19	:	:	PUNCT
fnp-6282	2	20	26	26	NUM
fnp-6282	2	21	february	february	NOUN
fnp-6282	2	22	2025	2025	NUM
fnp-6282	2	23	copyedited	copyedit	VERB
fnp-6282	2	24	by	by	ADP
fnp-6282	2	25	:	:	PUNCT
fnp-6282	2	26	vanessa	vanessa	PROPN
fnp-6282	2	27	s.	s.	PROPN
fnp-6282	2	28	goodwill	goodwill	PROPN
fnp-6282	2	29	published	publish	VERB
fnp-6282	2	30	:	:	PUNCT
fnp-6282	2	31	07	07	NUM
fnp-6282	2	32	march	march	PROPN
fnp-6282	2	33	2025	2025	NUM
fnp-6282	2	34	https://doi.org/10.17879/freeneuropathology-2025-6282	https://doi.org/10.17879/freeneuropathology-2025-6282	PROPN
fnp-6282	2	35	keywords	keyword	NOUN
fnp-6282	2	36	:	:	PUNCT
fnp-6282	2	37	alzheimer	alzheimer	PROPN
fnp-6282	2	38	’s	’s	PART
fnp-6282	2	39	disease	disease	NOUN
fnp-6282	2	40	,	,	PUNCT
fnp-6282	2	41	cytoophidia	cytoophidia	PROPN
fnp-6282	2	42	,	,	PUNCT
fnp-6282	2	43	phosphoribosyl	phosphoribosyl	ADJ
fnp-6282	2	44	pyrophosphate	pyrophosphate	NOUN
fnp-6282	2	45	synthetase	synthetase	NOUN
fnp-6282	2	46	,	,	PUNCT
fnp-6282	2	47	intranuclear	intranuclear	NOUN
fnp-6282	2	48	rodlets	rodlet	NOUN
fnp-6282	2	49	,	,	PUNCT
fnp-6282	2	50	purines	purine	NOUN
fnp-6282	2	51	abstract	abstract	ADV
fnp-6282	2	52	there	there	PRON
fnp-6282	2	53	is	be	VERB
fnp-6282	2	54	considerable	considerable	ADJ
fnp-6282	2	55	evidence	evidence	NOUN
fnp-6282	2	56	for	for	ADP
fnp-6282	2	57	a	a	DET
fnp-6282	2	58	role	role	NOUN
fnp-6282	2	59	for	for	ADP
fnp-6282	2	60	metabolic	metabolic	NOUN
fnp-6282	2	61	dysregulation	dysregulation	NOUN
fnp-6282	2	62	,	,	PUNCT
fnp-6282	2	63	including	include	VERB
fnp-6282	2	64	disordered	disordered	ADJ
fnp-6282	2	65	purine	purine	NOUN
fnp-6282	2	66	nucleotide	nucleotide	NOUN
fnp-6282	2	67	metabolism	metabolism	NOUN
fnp-6282	2	68	,	,	PUNCT
fnp-6282	2	69	in	in	ADP
fnp-6282	2	70	the	the	DET
fnp-6282	2	71	pathogenesis	pathogenesis	NOUN
fnp-6282	2	72	of	of	ADP
fnp-6282	2	73	alzheimer	alzheimer	PROPN
fnp-6282	2	74	’s	’s	PART
fnp-6282	2	75	disease	disease	NOUN
fnp-6282	2	76	(	(	PUNCT
fnp-6282	2	77	ad	ad	NOUN
fnp-6282	2	78	)	)	PUNCT
fnp-6282	2	79	.	.	PUNCT
fnp-6282	3	1	purine	purine	NOUN
fnp-6282	3	2	nucleotide	nucleotide	ADJ
fnp-6282	3	3	synthesis	synthesis	NOUN
fnp-6282	3	4	in	in	ADP
fnp-6282	3	5	the	the	DET
fnp-6282	3	6	brain	brain	NOUN
fnp-6282	3	7	is	be	AUX
fnp-6282	3	8	regulated	regulate	VERB
fnp-6282	3	9	with	with	ADP
fnp-6282	3	10	high	high	ADJ
fnp-6282	3	11	fidelity	fidelity	NOUN
fnp-6282	3	12	to	to	PART
fnp-6282	3	13	co	co	VERB
fnp-6282	3	14	-	-	ADJ
fnp-6282	3	15	ordinate	ordinate	VERB
fnp-6282	3	16	supply	supply	NOUN
fnp-6282	3	17	with	with	ADP
fnp-6282	3	18	demand	demand	NOUN
fnp-6282	3	19	.	.	PUNCT
fnp-6282	4	1	the	the	DET
fnp-6282	4	2	assembly	assembly	NOUN
fnp-6282	4	3	of	of	ADP
fnp-6282	4	4	some	some	DET
fnp-6282	4	5	purine	purine	NOUN
fnp-6282	4	6	biosynthetic	biosynthetic	ADJ
fnp-6282	4	7	enzymes	enzyme	NOUN
fnp-6282	4	8	into	into	ADP
fnp-6282	4	9	linear	linear	ADJ
fnp-6282	4	10	filamentous	filamentous	ADJ
fnp-6282	4	11	aggregates	aggregate	NOUN
fnp-6282	4	12	called	call	VERB
fnp-6282	4	13	“	"	PUNCT
fnp-6282	4	14	cytoophidia	cytoophidia	PROPN
fnp-6282	4	15	”	"	PUNCT
fnp-6282	4	16	(	(	PUNCT
fnp-6282	4	17	gk	gk	PROPN
fnp-6282	4	18	.	.	NOUN
fnp-6282	4	19	cellular	cellular	ADJ
fnp-6282	4	20	“	"	PUNCT
fnp-6282	4	21	snakes	snake	NOUN
fnp-6282	4	22	”	"	PUNCT
fnp-6282	4	23	)	)	PUNCT
fnp-6282	4	24	represents	represent	VERB
fnp-6282	4	25	one	one	NUM
fnp-6282	4	26	post	post	ADJ
fnp-6282	4	27	-	-	ADJ
fnp-6282	4	28	translational	translational	ADJ
fnp-6282	4	29	mechanism	mechanism	NOUN
fnp-6282	4	30	to	to	PART
fnp-6282	4	31	regulate	regulate	VERB
fnp-6282	4	32	enzyme	enzyme	NOUN
fnp-6282	4	33	activity	activity	NOUN
fnp-6282	4	34	.	.	PUNCT
fnp-6282	5	1	cytoophidia	cytoophidia	PROPN
fnp-6282	5	2	comprised	comprise	VERB
fnp-6282	5	3	of	of	ADP
fnp-6282	5	4	the	the	DET
fnp-6282	5	5	nucleotide	nucleotide	ADJ
fnp-6282	5	6	biosynthetic	biosynthetic	ADJ
fnp-6282	5	7	enzymes	enzyme	NOUN
fnp-6282	5	8	inosine	inosine	NOUN
fnp-6282	5	9	monophosphate	monophosphate	NOUN
fnp-6282	5	10	dehydrogenase	dehydrogenase	NOUN
fnp-6282	5	11	(	(	PUNCT
fnp-6282	5	12	impdh	impdh	NOUN
fnp-6282	5	13	)	)	PUNCT
fnp-6282	5	14	and	and	CCONJ
fnp-6282	5	15	phosphoribosyl	phosphoribosyl	ADJ
fnp-6282	5	16	pyrophosphate	pyrophosphate	NOUN
fnp-6282	5	17	synthetase	synthetase	NOUN
fnp-6282	5	18	(	(	PUNCT
fnp-6282	5	19	prps	prps	PROPN
fnp-6282	5	20	)	)	PUNCT
fnp-6282	5	21	have	have	AUX
fnp-6282	5	22	been	be	AUX
fnp-6282	5	23	described	describe	VERB
fnp-6282	5	24	in	in	ADP
fnp-6282	5	25	neuronal	neuronal	ADJ
fnp-6282	5	26	nuclei	nucleus	NOUN
fnp-6282	5	27	(	(	PUNCT
fnp-6282	5	28	nuclear	nuclear	ADJ
fnp-6282	5	29	cytoophidia	cytoophidia	PROPN
fnp-6282	5	30	;	;	PUNCT
fnp-6282	5	31	ncs	nc	NOUN
fnp-6282	5	32	)	)	PUNCT
fnp-6282	5	33	.	.	PUNCT
fnp-6282	6	1	in	in	ADP
fnp-6282	6	2	light	light	NOUN
fnp-6282	6	3	of	of	ADP
fnp-6282	6	4	the	the	DET
fnp-6282	6	5	involvement	involvement	NOUN
fnp-6282	6	6	of	of	ADP
fnp-6282	6	7	purine	purine	NOUN
fnp-6282	6	8	nucleotide	nucleotide	NOUN
fnp-6282	6	9	dysmetabolism	dysmetabolism	NOUN
fnp-6282	6	10	in	in	ADP
fnp-6282	6	11	ad	ad	NOUN
fnp-6282	6	12	,	,	PUNCT
fnp-6282	6	13	the	the	DET
fnp-6282	6	14	rationale	rationale	NOUN
fnp-6282	6	15	for	for	ADP
fnp-6282	6	16	this	this	DET
fnp-6282	6	17	study	study	NOUN
fnp-6282	6	18	was	be	AUX
fnp-6282	6	19	to	to	PART
fnp-6282	6	20	determine	determine	VERB
fnp-6282	6	21	whether	whether	SCONJ
fnp-6282	6	22	there	there	PRON
fnp-6282	6	23	are	be	VERB
fnp-6282	6	24	disease	disease	NOUN
fnp-6282	6	25	-	-	PUNCT
fnp-6282	6	26	specific	specific	ADJ
fnp-6282	6	27	qualitative	qualitative	NOUN
fnp-6282	6	28	or	or	CCONJ
fnp-6282	6	29	quantitative	quantitative	ADJ
fnp-6282	6	30	alterations	alteration	NOUN
fnp-6282	6	31	in	in	ADP
fnp-6282	6	32	prps	prps	PROPN
fnp-6282	6	33	cytoophidia	cytoophidia	PROPN
fnp-6282	6	34	in	in	ADP
fnp-6282	6	35	the	the	DET
fnp-6282	6	36	ad	ad	NOUN
fnp-6282	6	37	brain	brain	NOUN
fnp-6282	6	38	.	.	PUNCT
fnp-6282	7	1	double	double	ADJ
fnp-6282	7	2	fluorescence	fluorescence	NOUN
fnp-6282	7	3	immunostaining	immunostaine	VERB
fnp-6282	7	4	for	for	ADP
fnp-6282	7	5	prps	prps	PROPN
fnp-6282	7	6	and	and	CCONJ
fnp-6282	7	7	the	the	DET
fnp-6282	7	8	neuronal	neuronal	ADJ
fnp-6282	7	9	marker	marker	NOUN
fnp-6282	7	10	map2	map2	NOUN
fnp-6282	7	11	was	be	AUX
fnp-6282	7	12	performed	perform	VERB
fnp-6282	7	13	on	on	ADP
fnp-6282	7	14	tissue	tissue	NOUN
fnp-6282	7	15	microarrays	microarray	NOUN
fnp-6282	7	16	of	of	ADP
fnp-6282	7	17	cores	core	NOUN
fnp-6282	7	18	of	of	ADP
fnp-6282	7	19	temporal	temporal	ADJ
fnp-6282	7	20	cortex	cortex	NOUN
fnp-6282	7	21	extracted	extract	VERB
fnp-6282	7	22	from	from	ADP
fnp-6282	7	23	post	post	ADJ
fnp-6282	7	24	-	-	ADJ
fnp-6282	7	25	mortem	mortem	ADJ
fnp-6282	7	26	tissue	tissue	NOUN
fnp-6282	7	27	blocks	block	NOUN
fnp-6282	7	28	from	from	ADP
fnp-6282	7	29	a	a	DET
fnp-6282	7	30	large	large	ADJ
fnp-6282	7	31	cohort	cohort	NOUN
fnp-6282	7	32	of	of	ADP
fnp-6282	7	33	participants	participant	NOUN
fnp-6282	7	34	with	with	ADP
fnp-6282	7	35	neuropathologically	neuropathologically	ADV
fnp-6282	7	36	confirmed	confirm	VERB
fnp-6282	7	37	ad	ad	NOUN
fnp-6282	7	38	,	,	PUNCT
fnp-6282	7	39	lewy	lewy	PROPN
fnp-6282	7	40	body	body	NOUN
fnp-6282	7	41	disease	disease	NOUN
fnp-6282	7	42	(	(	PUNCT
fnp-6282	7	43	lbd	lbd	PROPN
fnp-6282	7	44	)	)	PUNCT
fnp-6282	7	45	,	,	PUNCT
fnp-6282	7	46	progressive	progressive	ADJ
fnp-6282	7	47	supranuclear	supranuclear	ADJ
fnp-6282	7	48	palsy	palsy	ADJ
fnp-6282	7	49	,	,	PUNCT
fnp-6282	7	50	and	and	CCONJ
fnp-6282	7	51	corticobasal	corticobasal	NOUN
fnp-6282	7	52	degeneration	degeneration	NOUN
fnp-6282	7	53	,	,	PUNCT
fnp-6282	7	54	as	as	ADV
fnp-6282	7	55	well	well	ADV
fnp-6282	7	56	as	as	ADP
fnp-6282	7	57	age	age	NOUN
fnp-6282	7	58	-	-	PUNCT
fnp-6282	7	59	matched	match	VERB
fnp-6282	7	60	cognitively	cognitively	ADV
fnp-6282	7	61	unimpaired	unimpaire	VERB
fnp-6282	7	62	control	control	NOUN
fnp-6282	7	63	participants	participant	NOUN
fnp-6282	7	64	.	.	PUNCT
fnp-6282	8	1	the	the	DET
fnp-6282	8	2	latter	latter	ADJ
fnp-6282	8	3	group	group	NOUN
fnp-6282	8	4	included	include	VERB
fnp-6282	8	5	individuals	individual	NOUN
fnp-6282	8	6	with	with	ADP
fnp-6282	8	7	substantial	substantial	ADJ
fnp-6282	8	8	beta	beta	NOUN
fnp-6282	8	9	-	-	PUNCT
fnp-6282	8	10	amyloid	amyloid	NOUN
fnp-6282	8	11	deposition	deposition	NOUN
fnp-6282	8	12	.	.	PUNCT
fnp-6282	9	1	ncs	nc	NOUN
fnp-6282	9	2	were	be	AUX
fnp-6282	9	3	significantly	significantly	ADV
fnp-6282	9	4	reduced	reduce	VERB
fnp-6282	9	5	in	in	ADP
fnp-6282	9	6	frequency	frequency	NOUN
fnp-6282	9	7	in	in	ADP
fnp-6282	9	8	ad	ad	NOUN
fnp-6282	9	9	samples	sample	NOUN
fnp-6282	9	10	relative	relative	ADJ
fnp-6282	9	11	to	to	ADP
fnp-6282	9	12	those	those	PRON
fnp-6282	9	13	from	from	ADP
fnp-6282	9	14	controls	control	NOUN
fnp-6282	9	15	,	,	PUNCT
fnp-6282	9	16	including	include	VERB
fnp-6282	9	17	those	those	PRON
fnp-6282	9	18	with	with	ADP
fnp-6282	9	19	a	a	DET
fnp-6282	9	20	high	high	ADJ
fnp-6282	9	21	beta	beta	NOUN
fnp-6282	9	22	-	-	PUNCT
fnp-6282	9	23	amyloid	amyloid	NOUN
fnp-6282	9	24	load	load	NOUN
fnp-6282	9	25	,	,	PUNCT
fnp-6282	9	26	or	or	CCONJ
fnp-6282	9	27	participants	participant	NOUN
fnp-6282	9	28	with	with	ADP
fnp-6282	9	29	lbd	lbd	PROPN
fnp-6282	9	30	or	or	CCONJ
fnp-6282	9	31	4	4	NUM
fnp-6282	9	32	repeat	repeat	NOUN
fnp-6282	9	33	tauopathies	tauopathie	NOUN
fnp-6282	9	34	.	.	PUNCT
fnp-6282	10	1	moreover	moreover	ADV
fnp-6282	10	2	,	,	PUNCT
fnp-6282	10	3	double	double	ADJ
fnp-6282	10	4	staining	stain	VERB
fnp-6282	10	5	for	for	ADP
fnp-6282	10	6	prps	prps	PROPN
fnp-6282	10	7	and	and	CCONJ
fnp-6282	10	8	hyperphosphorylated	hyperphosphorylate	VERB
fnp-6282	10	9	tau	tau	PROPN
fnp-6282	10	10	revealed	reveal	VERB
fnp-6282	10	11	evidence	evidence	NOUN
fnp-6282	10	12	for	for	ADP
fnp-6282	10	13	an	an	DET
fnp-6282	10	14	association	association	NOUN
fnp-6282	10	15	between	between	ADP
fnp-6282	10	16	ncs	ncs	NOUN
fnp-6282	10	17	and	and	CCONJ
fnp-6282	10	18	neurofibrillary	neurofibrillary	ADJ
fnp-6282	10	19	tangles	tangle	NOUN
fnp-6282	10	20	.	.	PUNCT
fnp-6282	11	1	the	the	DET
fnp-6282	11	2	results	result	NOUN
fnp-6282	11	3	of	of	ADP
fnp-6282	11	4	this	this	DET
fnp-6282	11	5	study	study	NOUN
fnp-6282	11	6	contribute	contribute	VERB
fnp-6282	11	7	to	to	ADP
fnp-6282	11	8	our	our	PRON
fnp-6282	11	9	understanding	understanding	NOUN
fnp-6282	11	10	of	of	ADP
fnp-6282	11	11	metabolic	metabolic	NOUN
fnp-6282	11	12	contributions	contribution	NOUN
fnp-6282	11	13	to	to	ADP
fnp-6282	11	14	ad	ad	NOUN
fnp-6282	11	15	pathogenesis	pathogenesis	NOUN
fnp-6282	11	16	and	and	CCONJ
fnp-6282	11	17	provide	provide	VERB
fnp-6282	11	18	a	a	DET
fnp-6282	11	19	novel	novel	ADJ
fnp-6282	11	20	avenue	avenue	NOUN
fnp-6282	11	21	for	for	ADP
fnp-6282	11	22	future	future	ADJ
fnp-6282	11	23	studies	study	NOUN
fnp-6282	11	24	.	.	PUNCT
fnp-6282	12	1	moreover	moreover	ADV
fnp-6282	12	2	,	,	PUNCT
fnp-6282	12	3	because	because	SCONJ
fnp-6282	12	4	prps	prps	PROPN
fnp-6282	12	5	filamentation	filamentation	NOUN
fnp-6282	12	6	is	be	AUX
fnp-6282	12	7	responsive	responsive	ADJ
fnp-6282	12	8	to	to	ADP
fnp-6282	12	9	a	a	DET
fnp-6282	12	10	variety	variety	NOUN
fnp-6282	12	11	of	of	ADP
fnp-6282	12	12	drugs	drug	NOUN
fnp-6282	12	13	and	and	CCONJ
fnp-6282	12	14	metabolites	metabolite	NOUN
fnp-6282	12	15	,	,	PUNCT
fnp-6282	12	16	they	they	PRON
fnp-6282	12	17	may	may	AUX
fnp-6282	12	18	have	have	VERB
fnp-6282	12	19	implications	implication	NOUN
fnp-6282	12	20	for	for	ADP
fnp-6282	12	21	the	the	DET
fnp-6282	12	22	development	development	NOUN
fnp-6282	12	23	of	of	ADP
fnp-6282	12	24	biologically	biologically	ADV
fnp-6282	12	25	rational	rational	ADJ
fnp-6282	12	26	therapies	therapy	NOUN
fnp-6282	12	27	.	.	PUNCT
fnp-6282	13	1	introduction	introduction	NOUN
fnp-6282	13	2	alzheimer	alzheimer	PROPN
fnp-6282	13	3	's	's	PART
fnp-6282	13	4	disease	disease	NOUN
fnp-6282	13	5	(	(	PUNCT
fnp-6282	13	6	ad	ad	NOUN
fnp-6282	13	7	)	)	PUNCT
fnp-6282	13	8	is	be	AUX
fnp-6282	13	9	a	a	DET
fnp-6282	13	10	devastating	devastating	ADJ
fnp-6282	13	11	neurodegenerative	neurodegenerative	ADJ
fnp-6282	13	12	disease	disease	NOUN
fnp-6282	13	13	characterized	characterize	VERB
fnp-6282	13	14	clinically	clinically	ADV
fnp-6282	13	15	by	by	ADP
fnp-6282	13	16	inexorable	inexorable	ADJ
fnp-6282	13	17	,	,	PUNCT
fnp-6282	13	18	progressive	progressive	ADJ
fnp-6282	13	19	impairments	impairment	NOUN
fnp-6282	13	20	in	in	ADP
fnp-6282	13	21	memory	memory	NOUN
fnp-6282	13	22	,	,	PUNCT
fnp-6282	13	23	judgement	judgement	NOUN
fnp-6282	13	24	,	,	PUNCT
fnp-6282	13	25	and	and	CCONJ
fnp-6282	13	26	reasoning	reasoning	NOUN
fnp-6282	13	27	.	.	PUNCT
fnp-6282	14	1	the	the	DET
fnp-6282	14	2	disease	disease	NOUN
fnp-6282	14	3	is	be	AUX
fnp-6282	14	4	characterized	characterize	VERB
fnp-6282	14	5	histopathologically	histopathologically	ADV
fnp-6282	14	6	by	by	ADP
fnp-6282	14	7	the	the	DET
fnp-6282	14	8	buildup	buildup	NOUN
fnp-6282	14	9	of	of	ADP
fnp-6282	14	10	beta	beta	NOUN
fnp-6282	14	11	-	-	PUNCT
fnp-6282	14	12	amyloid	amyloid	NOUN
fnp-6282	14	13	plaques	plaque	NOUN
fnp-6282	14	14	and	and	CCONJ
fnp-6282	14	15	the	the	DET
fnp-6282	14	16	presence	presence	NOUN
fnp-6282	14	17	of	of	ADP
fnp-6282	14	18	neurofibrillary	neurofibrillary	ADJ
fnp-6282	14	19	tangles	tangle	NOUN
fnp-6282	14	20	made	make	VERB
fnp-6282	14	21	up	up	ADP
fnp-6282	14	22	of	of	ADP
fnp-6282	14	23	phosphorylated	phosphorylate	VERB
fnp-6282	14	24	tau	tau	PROPN
fnp-6282	14	25	protein	protein	NOUN
fnp-6282	14	26	.	.	PUNCT
fnp-6282	15	1	although	although	SCONJ
fnp-6282	15	2	genetic	genetic	ADJ
fnp-6282	15	3	evidence	evidence	NOUN
fnp-6282	15	4	supports	support	VERB
fnp-6282	15	5	a	a	DET
fnp-6282	15	6	critical	critical	ADJ
fnp-6282	15	7	role	role	NOUN
fnp-6282	15	8	for	for	ADP
fnp-6282	15	9	beta	beta	NOUN
fnp-6282	15	10	-	-	PUNCT
fnp-6282	15	11	amyloid	amyloid	NOUN
fnp-6282	15	12	in	in	ADP
fnp-6282	15	13	the	the	DET
fnp-6282	15	14	pathogenesis	pathogenesis	NOUN
fnp-6282	15	15	of	of	ADP
fnp-6282	15	16	familial	familial	ADJ
fnp-6282	15	17	forms	form	NOUN
fnp-6282	15	18	of	of	ADP
fnp-6282	15	19	ad	ad	NOUN
fnp-6282	15	20	,	,	PUNCT
fnp-6282	15	21	the	the	DET
fnp-6282	15	22	pathogenetic	pathogenetic	ADJ
fnp-6282	15	23	mechanisms	mechanism	NOUN
fnp-6282	15	24	underlying	underlie	VERB
fnp-6282	15	25	the	the	DET
fnp-6282	15	26	far	far	ADV
fnp-6282	15	27	more	more	ADV
fnp-6282	15	28	common	common	ADJ
fnp-6282	15	29	sporadic	sporadic	ADJ
fnp-6282	15	30	form	form	NOUN
fnp-6282	15	31	of	of	ADP
fnp-6282	15	32	ad	ad	NOUN
fnp-6282	15	33	remain	remain	VERB
fnp-6282	15	34	enigmatic	enigmatic	ADJ
fnp-6282	15	35	.	.	PUNCT
fnp-6282	16	1	there	there	PRON
fnp-6282	16	2	is	be	VERB
fnp-6282	16	3	growing	grow	VERB
fnp-6282	16	4	evidence	evidence	NOUN
fnp-6282	16	5	for	for	ADP
fnp-6282	16	6	a	a	DET
fnp-6282	16	7	role	role	NOUN
fnp-6282	16	8	for	for	ADP
fnp-6282	16	9	metabolic	metabolic	NOUN
fnp-6282	16	10	dysregulation	dysregulation	NOUN
fnp-6282	16	11	in	in	ADP
fnp-6282	16	12	ad	ad	NOUN
fnp-6282	16	13	,	,	PUNCT
fnp-6282	16	14	including	include	VERB
fnp-6282	16	15	nucleotide	nucleotide	ADJ
fnp-6282	16	16	dysmetabolism	dysmetabolism	NOUN
fnp-6282	16	17	,	,	PUNCT
fnp-6282	16	18	at	at	ADP
fnp-6282	16	19	early	early	ADJ
fnp-6282	16	20	stages	stage	NOUN
fnp-6282	16	21	of	of	ADP
fnp-6282	16	22	ad	ad	NOUN
fnp-6282	16	23	independent	independent	ADJ
fnp-6282	16	24	of	of	ADP
fnp-6282	16	25	neurofibrillary	neurofibrillary	ADJ
fnp-6282	16	26	tangles	tangle	NOUN
fnp-6282	16	27	and	and	CCONJ
fnp-6282	16	28	β	β	NOUN
fnp-6282	16	29	-	-	ADJ
fnp-6282	16	30	amyloid	amyloid	ADJ
fnp-6282	16	31	plaques	plaque	NOUN
fnp-6282	16	32	[	[	X
fnp-6282	16	33	1	1	NUM
fnp-6282	16	34	,	,	PUNCT
fnp-6282	16	35	3	3	NUM
fnp-6282	16	36	,	,	PUNCT
fnp-6282	16	37	26	26	NUM
fnp-6282	16	38	,	,	PUNCT
fnp-6282	16	39	29–31	29–31	PROPN
fnp-6282	16	40	]	]	PUNCT
fnp-6282	16	41	.	.	PUNCT
fnp-6282	17	1	there	there	PRON
fnp-6282	17	2	is	be	VERB
fnp-6282	17	3	deregulated	deregulated	ADJ
fnp-6282	17	4	expression	expression	NOUN
fnp-6282	17	5	of	of	ADP
fnp-6282	17	6	a	a	DET
fnp-6282	17	7	number	number	NOUN
fnp-6282	17	8	of	of	ADP
fnp-6282	17	9	purine	purine	NOUN
fnp-6282	17	10	metabolic	metabolic	NOUN
fnp-6282	17	11	enzymes	enzyme	NOUN
fnp-6282	17	12	in	in	ADP
fnp-6282	17	13	ad	ad	NOUN
fnp-6282	17	14	as	as	ADV
fnp-6282	17	15	well	well	ADV
fnp-6282	17	16	as	as	ADP
fnp-6282	17	17	significantly	significantly	ADV
fnp-6282	17	18	altered	alter	VERB
fnp-6282	17	19	levels	level	NOUN
fnp-6282	17	20	of	of	ADP
fnp-6282	17	21	metabolites	metabolite	NOUN
fnp-6282	17	22	including	include	VERB
fnp-6282	17	23	dgmp	dgmp	NOUN
fnp-6282	17	24	,	,	PUNCT
fnp-6282	17	25	glycine	glycine	NOUN
fnp-6282	17	26	,	,	PUNCT
fnp-6282	17	27	xanthosine	xanthosine	PROPN
fnp-6282	17	28	,	,	PUNCT
fnp-6282	17	29	inosine	inosine	PROPN
fnp-6282	17	30	diphosphate	diphosphate	PROPN
fnp-6282	17	31	,	,	PUNCT
fnp-6282	17	32	guanine	guanine	NOUN
fnp-6282	17	33	,	,	PUNCT
fnp-6282	17	34	and	and	CCONJ
fnp-6282	17	35	deoxyguanosine	deoxyguanosine	VERB
fnp-6282	18	1	[	[	X
fnp-6282	18	2	3	3	NUM
fnp-6282	18	3	]	]	PUNCT
fnp-6282	18	4	.	.	PUNCT
fnp-6282	19	1	the	the	DET
fnp-6282	19	2	brain	brain	NOUN
fnp-6282	19	3	is	be	AUX
fnp-6282	19	4	critically	critically	ADV
fnp-6282	19	5	dependent	dependent	ADJ
fnp-6282	19	6	on	on	ADP
fnp-6282	19	7	an	an	DET
fnp-6282	19	8	uninterrupted	uninterrupted	ADJ
fnp-6282	19	9	supply	supply	NOUN
fnp-6282	19	10	of	of	ADP
fnp-6282	19	11	purine	purine	NOUN
fnp-6282	19	12	nucleotides	nucleotide	NOUN
fnp-6282	19	13	(	(	PUNCT
fnp-6282	19	14	amp	amp	PROPN
fnp-6282	19	15	,	,	PUNCT
fnp-6282	19	16	adp	adp	PROPN
fnp-6282	19	17	,	,	PUNCT
fnp-6282	19	18	atp	atp	PROPN
fnp-6282	19	19	,	,	PUNCT
fnp-6282	19	20	gmp	gmp	PROPN
fnp-6282	19	21	,	,	PUNCT
fnp-6282	19	22	gdp	gdp	PROPN
fnp-6282	19	23	,	,	PUNCT
fnp-6282	19	24	gtp	gtp	PROPN
fnp-6282	19	25	)	)	PUNCT
fnp-6282	19	26	.	.	PUNCT
fnp-6282	20	1	they	they	PRON
fnp-6282	20	2	are	be	AUX
fnp-6282	20	3	assembled	assemble	VERB
fnp-6282	20	4	into	into	ADP
fnp-6282	20	5	rna	rna	NOUN
fnp-6282	20	6	and	and	CCONJ
fnp-6282	20	7	dna	dna	PROPN
fnp-6282	20	8	,	,	PUNCT
fnp-6282	20	9	provide	provide	VERB
fnp-6282	20	10	energy	energy	NOUN
fnp-6282	20	11	for	for	ADP
fnp-6282	20	12	cells	cell	NOUN
fnp-6282	20	13	,	,	PUNCT
fnp-6282	20	14	are	be	AUX
fnp-6282	20	15	used	use	VERB
fnp-6282	20	16	as	as	ADP
fnp-6282	20	17	signalling	signal	VERB
fnp-6282	20	18	molecules	molecule	NOUN
fnp-6282	20	19	,	,	PUNCT
fnp-6282	20	20	and	and	CCONJ
fnp-6282	20	21	are	be	AUX
fnp-6282	20	22	incorporated	incorporate	VERB
fnp-6282	20	23	into	into	ADP
fnp-6282	20	24	co	co	NOUN
fnp-6282	20	25	-	-	NOUN
fnp-6282	20	26	enzymes	enzyme	NOUN
fnp-6282	20	27	.	.	PUNCT
fnp-6282	21	1	accordingly	accordingly	ADV
fnp-6282	21	2	,	,	PUNCT
fnp-6282	21	3	inborn	inborn	ADJ
fnp-6282	21	4	errors	error	NOUN
fnp-6282	21	5	of	of	ADP
fnp-6282	21	6	purine	purine	NOUN
fnp-6282	21	7	nucleotide	nucleotide	ADJ
fnp-6282	21	8	metabolism	metabolism	NOUN
fnp-6282	21	9	markedly	markedly	ADV
fnp-6282	21	10	,	,	PUNCT
fnp-6282	21	11	and	and	CCONJ
fnp-6282	21	12	relatively	relatively	ADV
fnp-6282	21	13	selectively	selectively	ADV
fnp-6282	21	14	impact	impact	VERB
fnp-6282	21	15	the	the	DET
fnp-6282	21	16	nervous	nervous	ADJ
fnp-6282	21	17	system	system	NOUN
fnp-6282	21	18	,	,	PUNCT
fnp-6282	21	19	resulting	result	VERB
fnp-6282	21	20	in	in	ADP
fnp-6282	21	21	severe	severe	ADJ
fnp-6282	21	22	neurodevelopmental	neurodevelopmental	ADJ
fnp-6282	21	23	diseases	disease	NOUN
fnp-6282	21	24	[	[	X
fnp-6282	21	25	16	16	NUM
fnp-6282	21	26	,	,	PUNCT
fnp-6282	21	27	27	27	NUM
fnp-6282	21	28	,	,	PUNCT
fnp-6282	21	29	38	38	NUM
fnp-6282	21	30	,	,	PUNCT
fnp-6282	21	31	42	42	NUM
fnp-6282	21	32	,	,	PUNCT
fnp-6282	21	33	51	51	NUM
fnp-6282	21	34	,	,	PUNCT
fnp-6282	21	35	52	52	NUM
fnp-6282	21	36	,	,	PUNCT
fnp-6282	21	37	66	66	NUM
fnp-6282	21	38	]	]	PUNCT
fnp-6282	21	39	.	.	PUNCT
fnp-6282	22	1	the	the	DET
fnp-6282	22	2	synthesis	synthesis	NOUN
fnp-6282	22	3	of	of	ADP
fnp-6282	22	4	purine	purine	NOUN
fnp-6282	22	5	nucleotides	nucleotide	NOUN
fnp-6282	22	6	is	be	AUX
fnp-6282	22	7	carefully	carefully	ADV
fnp-6282	22	8	regulated	regulate	VERB
fnp-6282	22	9	to	to	PART
fnp-6282	22	10	calibrate	calibrate	VERB
fnp-6282	22	11	supply	supply	NOUN
fnp-6282	22	12	with	with	ADP
fnp-6282	22	13	cellular	cellular	ADJ
fnp-6282	22	14	demand	demand	NOUN
fnp-6282	22	15	.	.	PUNCT
fnp-6282	23	1	in	in	ADP
fnp-6282	23	2	response	response	NOUN
fnp-6282	23	3	to	to	ADP
fnp-6282	23	4	purine	purine	NOUN
fnp-6282	23	5	limitation	limitation	NOUN
fnp-6282	23	6	or	or	CCONJ
fnp-6282	23	7	a	a	DET
fnp-6282	23	8	variety	variety	NOUN
fnp-6282	23	9	of	of	ADP
fnp-6282	23	10	manipulations	manipulation	NOUN
fnp-6282	23	11	,	,	PUNCT
fnp-6282	23	12	enzymes	enzyme	NOUN
fnp-6282	23	13	involved	involve	VERB
fnp-6282	23	14	in	in	ADP
fnp-6282	23	15	the	the	DET
fnp-6282	23	16	de	de	X
fnp-6282	23	17	novo	novo	NOUN
fnp-6282	23	18	purine	purine	NOUN
fnp-6282	23	19	pathway	pathway	NOUN
fnp-6282	23	20	are	be	AUX
fnp-6282	23	21	assembled	assemble	VERB
fnp-6282	23	22	by	by	ADP
fnp-6282	23	23	liquid	liquid	NOUN
fnp-6282	23	24	-	-	PUNCT
fnp-6282	23	25	liquid	liquid	ADJ
fnp-6282	23	26	phase	phase	NOUN
fnp-6282	23	27	separation	separation	NOUN
fnp-6282	23	28	into	into	ADP
fnp-6282	23	29	microscopically	microscopically	ADV
fnp-6282	23	30	visible	visible	ADJ
fnp-6282	23	31	,	,	PUNCT
fnp-6282	23	32	supramolecular	supramolecular	ADJ
fnp-6282	23	33	membraneless	membraneless	NOUN
fnp-6282	23	34	organelles	organelle	NOUN
fnp-6282	23	35	comprised	comprise	VERB
fnp-6282	23	36	of	of	ADP
fnp-6282	23	37	nine	nine	NUM
fnp-6282	23	38	enzymes	enzyme	NOUN
fnp-6282	23	39	called	call	VERB
fnp-6282	23	40	"	"	PUNCT
fnp-6282	23	41	purinosomes	purinosome	NOUN
fnp-6282	23	42	"	"	PUNCT
fnp-6282	23	43	[	[	X
fnp-6282	23	44	54	54	NUM
fnp-6282	23	45	]	]	PUNCT
fnp-6282	23	46	.	.	PUNCT
fnp-6282	24	1	by	by	ADP
fnp-6282	24	2	virtue	virtue	NOUN
fnp-6282	24	3	of	of	ADP
fnp-6282	24	4	the	the	DET
fnp-6282	24	5	physical	physical	ADJ
fnp-6282	24	6	proximity	proximity	NOUN
fnp-6282	24	7	of	of	ADP
fnp-6282	24	8	their	their	PRON
fnp-6282	24	9	constituent	constituent	NOUN
fnp-6282	24	10	enzymes	enzyme	NOUN
fnp-6282	24	11	,	,	PUNCT
fnp-6282	24	12	these	these	DET
fnp-6282	24	13	"	"	PUNCT
fnp-6282	24	14	metabolon	metabolon	NOUN
fnp-6282	24	15	"	"	PUNCT
fnp-6282	24	16	structures	structure	NOUN
fnp-6282	24	17	more	more	ADV
fnp-6282	24	18	efficiently	efficiently	ADV
fnp-6282	24	19	catalyze	catalyze	VERB
fnp-6282	24	20	the	the	DET
fnp-6282	24	21	generation	generation	NOUN
fnp-6282	24	22	of	of	ADP
fnp-6282	24	23	amp	amp	PROPN
fnp-6282	24	24	and	and	CCONJ
fnp-6282	24	25	gmp	gmp	PROPN
fnp-6282	24	26	in	in	ADP
fnp-6282	24	27	response	response	NOUN
fnp-6282	24	28	to	to	ADP
fnp-6282	24	29	metabolic	metabolic	NOUN
fnp-6282	24	30	demand	demand	NOUN
fnp-6282	24	31	[	[	X
fnp-6282	24	32	53	53	NUM
fnp-6282	24	33	]	]	PUNCT
fnp-6282	24	34	.	.	PUNCT
fnp-6282	25	1	in	in	ADP
fnp-6282	25	2	addition	addition	NOUN
fnp-6282	25	3	to	to	ADP
fnp-6282	25	4	purinosomes	purinosome	NOUN
fnp-6282	25	5	,	,	PUNCT
fnp-6282	25	6	a	a	DET
fnp-6282	25	7	subset	subset	NOUN
fnp-6282	25	8	of	of	ADP
fnp-6282	25	9	nucleotide	nucleotide	NOUN
fnp-6282	25	10	-	-	PUNCT
fnp-6282	25	11	synthesizing	synthesize	VERB
fnp-6282	25	12	enzymes	enzyme	NOUN
fnp-6282	25	13	are	be	AUX
fnp-6282	25	14	subject	subject	ADJ
fnp-6282	25	15	to	to	ADP
fnp-6282	25	16	an	an	DET
fnp-6282	25	17	additional	additional	ADJ
fnp-6282	25	18	level	level	NOUN
fnp-6282	25	19	of	of	ADP
fnp-6282	25	20	supramolecular	supramolecular	ADJ
fnp-6282	25	21	regulation	regulation	NOUN
fnp-6282	25	22	;	;	PUNCT
fnp-6282	25	23	the	the	DET
fnp-6282	25	24	formation	formation	NOUN
fnp-6282	25	25	of	of	ADP
fnp-6282	25	26	linear	linear	ADJ
fnp-6282	25	27	filamentous	filamentous	ADJ
fnp-6282	25	28	assemblies	assembly	NOUN
fnp-6282	25	29	as	as	ADP
fnp-6282	25	30	a	a	DET
fnp-6282	25	31	biological	biological	ADJ
fnp-6282	25	32	regulatory	regulatory	ADJ
fnp-6282	25	33	mechanism	mechanism	NOUN
fnp-6282	25	34	to	to	PART
fnp-6282	25	35	co	co	VERB
fnp-6282	25	36	-	-	ADJ
fnp-6282	25	37	ordinate	ordinate	VERB
fnp-6282	25	38	enzyme	enzyme	NOUN
fnp-6282	25	39	activity	activity	NOUN
fnp-6282	25	40	with	with	ADP
fnp-6282	25	41	cellular	cellular	ADJ
fnp-6282	25	42	requirements	requirement	NOUN
fnp-6282	25	43	[	[	X
fnp-6282	25	44	5	5	NUM
fnp-6282	25	45	,	,	PUNCT
fnp-6282	25	46	28	28	NUM
fnp-6282	25	47	,	,	PUNCT
fnp-6282	25	48	41	41	NUM
fnp-6282	25	49	,	,	PUNCT
fnp-6282	25	50	58	58	NUM
fnp-6282	25	51	]	]	PUNCT
fnp-6282	25	52	.	.	PUNCT
fnp-6282	26	1	the	the	DET
fnp-6282	26	2	relationship	relationship	NOUN
fnp-6282	26	3	between	between	ADP
fnp-6282	26	4	filament	filament	NOUN
fnp-6282	26	5	formation	formation	NOUN
fnp-6282	26	6	and	and	CCONJ
fnp-6282	26	7	enzyme	enzyme	NOUN
fnp-6282	26	8	activity	activity	NOUN
fnp-6282	26	9	is	be	AUX
fnp-6282	26	10	complex	complex	ADJ
fnp-6282	26	11	as	as	SCONJ
fnp-6282	26	12	both	both	CCONJ
fnp-6282	26	13	active	active	ADJ
fnp-6282	26	14	and	and	CCONJ
fnp-6282	26	15	inactive	inactive	ADJ
fnp-6282	26	16	multimeric	multimeric	ADJ
fnp-6282	26	17	conformers	conformer	NOUN
fnp-6282	26	18	are	be	AUX
fnp-6282	26	19	present	present	ADJ
fnp-6282	26	20	within	within	ADP
fnp-6282	26	21	individual	individual	ADJ
fnp-6282	26	22	filaments	filament	NOUN
fnp-6282	26	23	[	[	X
fnp-6282	26	24	28	28	NUM
fnp-6282	26	25	]	]	PUNCT
fnp-6282	26	26	.	.	PUNCT
fnp-6282	27	1	current	current	ADJ
fnp-6282	27	2	consensus	consensus	NOUN
fnp-6282	27	3	supports	support	VERB
fnp-6282	27	4	a	a	DET
fnp-6282	27	5	model	model	NOUN
fnp-6282	27	6	whereby	whereby	SCONJ
fnp-6282	27	7	filament	filament	NOUN
fnp-6282	27	8	formation	formation	NOUN
fnp-6282	27	9	correlates	correlate	VERB
fnp-6282	27	10	with	with	ADP
fnp-6282	27	11	increased	increase	VERB
fnp-6282	27	12	enzyme	enzyme	NOUN
fnp-6282	27	13	activity	activity	NOUN
fnp-6282	27	14	by	by	ADP
fnp-6282	27	15	resisting	resist	VERB
fnp-6282	27	16	feedback	feedback	NOUN
fnp-6282	27	17	inhibition	inhibition	NOUN
fnp-6282	27	18	by	by	ADP
fnp-6282	27	19	enzyme	enzyme	NOUN
fnp-6282	27	20	products	product	NOUN
fnp-6282	27	21	[	[	X
fnp-6282	27	22	28	28	NUM
fnp-6282	27	23	]	]	PUNCT
fnp-6282	27	24	.	.	PUNCT
fnp-6282	28	1	this	this	PRON
fnp-6282	28	2	adds	add	VERB
fnp-6282	28	3	nuance	nuance	NOUN
fnp-6282	28	4	to	to	PART
fnp-6282	28	5	purinosome	purinosome	VERB
fnp-6282	28	6	function	function	NOUN
fnp-6282	28	7	;	;	PUNCT
fnp-6282	28	8	permitting	permit	VERB
fnp-6282	28	9	ongoing	ongoing	ADJ
fnp-6282	28	10	nucleotide	nucleotide	ADJ
fnp-6282	28	11	synthesis	synthesis	NOUN
fnp-6282	28	12	under	under	ADP
fnp-6282	28	13	conditions	condition	NOUN
fnp-6282	28	14	of	of	ADP
fnp-6282	28	15	increased	increase	VERB
fnp-6282	28	16	nucleotide	nucleotide	NOUN
fnp-6282	28	17	demand	demand	NOUN
fnp-6282	28	18	,	,	PUNCT
fnp-6282	28	19	even	even	ADV
fnp-6282	28	20	when	when	SCONJ
fnp-6282	28	21	purines	purine	NOUN
fnp-6282	28	22	are	be	AUX
fnp-6282	28	23	plentiful	plentiful	ADJ
fnp-6282	28	24	.	.	PUNCT
fnp-6282	29	1	individual	individual	ADJ
fnp-6282	29	2	enzyme	enzyme	NOUN
fnp-6282	29	3	filaments	filament	NOUN
fnp-6282	29	4	can	can	AUX
fnp-6282	29	5	aggregate	aggregate	VERB
fnp-6282	29	6	by	by	ADP
fnp-6282	29	7	side	side	NOUN
fnp-6282	29	8	-	-	PUNCT
fnp-6282	29	9	to	to	ADP
fnp-6282	29	10	-	-	PUNCT
fnp-6282	29	11	side	side	NOUN
fnp-6282	29	12	lateral	lateral	ADJ
fnp-6282	29	13	alignment	alignment	NOUN
fnp-6282	29	14	to	to	PART
fnp-6282	29	15	form	form	VERB
fnp-6282	29	16	larger	large	ADJ
fnp-6282	29	17	,	,	PUNCT
fnp-6282	29	18	mesoscale	mesoscale	ADJ
fnp-6282	29	19	filament	filament	NOUN
fnp-6282	29	20	bundles	bundle	NOUN
fnp-6282	29	21	,	,	PUNCT
fnp-6282	29	22	which	which	PRON
fnp-6282	29	23	have	have	AUX
fnp-6282	29	24	been	be	AUX
fnp-6282	29	25	variously	variously	ADV
fnp-6282	29	26	referred	refer	VERB
fnp-6282	29	27	to	to	PART
fnp-6282	29	28	simply	simply	ADV
fnp-6282	29	29	as	as	ADP
fnp-6282	29	30	"	"	PUNCT
fnp-6282	29	31	filaments	filament	NOUN
fnp-6282	29	32	"	"	PUNCT
fnp-6282	29	33	,	,	PUNCT
fnp-6282	29	34	"	"	PUNCT
fnp-6282	29	35	rods	rod	NOUN
fnp-6282	29	36	and	and	CCONJ
fnp-6282	29	37	ring	ring	NOUN
fnp-6282	29	38	structures	structure	NOUN
fnp-6282	29	39	"	"	PUNCT
fnp-6282	29	40	or	or	CCONJ
fnp-6282	29	41	"	"	PUNCT
fnp-6282	29	42	cytoophidia	cytoophidia	X
fnp-6282	29	43	"	"	PUNCT
fnp-6282	29	44	(	(	PUNCT
fnp-6282	29	45	greek	greek	NOUN
fnp-6282	29	46	for	for	ADP
fnp-6282	29	47	"	"	PUNCT
fnp-6282	29	48	cellular	cellular	ADJ
fnp-6282	29	49	snakes	snake	NOUN
fnp-6282	29	50	"	"	PUNCT
fnp-6282	29	51	;	;	PUNCT
fnp-6282	29	52	reviewed	review	VERB
fnp-6282	29	53	in	in	ADP
fnp-6282	29	54	[	[	X
fnp-6282	29	55	12	12	NUM
fnp-6282	29	56	,	,	PUNCT
fnp-6282	29	57	40	40	NUM
fnp-6282	29	58	]	]	PUNCT
fnp-6282	29	59	)	)	PUNCT
fnp-6282	29	60	.	.	PUNCT
fnp-6282	30	1	the	the	DET
fnp-6282	30	2	formation	formation	NOUN
fnp-6282	30	3	of	of	ADP
fnp-6282	30	4	these	these	DET
fnp-6282	30	5	structures	structure	NOUN
fnp-6282	30	6	at	at	ADP
fnp-6282	30	7	steady	steady	ADJ
fnp-6282	30	8	state	state	NOUN
fnp-6282	30	9	and	and	CCONJ
fnp-6282	30	10	in	in	ADP
fnp-6282	30	11	response	response	NOUN
fnp-6282	30	12	to	to	ADP
fnp-6282	30	13	metabolic	metabolic	NOUN
fnp-6282	30	14	perturbations	perturbation	NOUN
fnp-6282	30	15	has	have	AUX
fnp-6282	30	16	been	be	AUX
fnp-6282	30	17	described	describe	VERB
fnp-6282	30	18	in	in	ADP
fnp-6282	30	19	a	a	DET
fnp-6282	30	20	variety	variety	NOUN
fnp-6282	30	21	of	of	ADP
fnp-6282	30	22	cell	cell	NOUN
fnp-6282	30	23	types	type	NOUN
fnp-6282	30	24	both	both	CCONJ
fnp-6282	30	25	in	in	ADP
fnp-6282	30	26	vitro	vitro	X
fnp-6282	30	27	and	and	CCONJ
fnp-6282	30	28	in	in	ADP
fnp-6282	30	29	vivo	vivo	NOUN
fnp-6282	30	30	[	[	X
fnp-6282	30	31	12	12	NUM
fnp-6282	30	32	]	]	PUNCT
fnp-6282	30	33	.	.	PUNCT
fnp-6282	31	1	these	these	DET
fnp-6282	31	2	filament	filament	NOUN
fnp-6282	31	3	bundles	bundle	NOUN
fnp-6282	31	4	have	have	AUX
fnp-6282	31	5	been	be	AUX
fnp-6282	31	6	described	describe	VERB
fnp-6282	31	7	both	both	CCONJ
fnp-6282	31	8	in	in	ADP
fnp-6282	31	9	the	the	DET
fnp-6282	31	10	cytoplasm	cytoplasm	NOUN
fnp-6282	31	11	and	and	CCONJ
fnp-6282	31	12	the	the	DET
fnp-6282	31	13	nucleus	nucleus	NOUN
fnp-6282	31	14	of	of	ADP
fnp-6282	31	15	a	a	DET
fnp-6282	31	16	variety	variety	NOUN
fnp-6282	31	17	of	of	ADP
fnp-6282	31	18	cell	cell	NOUN
fnp-6282	31	19	types	type	NOUN
fnp-6282	31	20	,	,	PUNCT
fnp-6282	31	21	including	include	VERB
fnp-6282	31	22	mammalian	mammalian	ADJ
fnp-6282	31	23	neurons	neuron	NOUN
fnp-6282	31	24	[	[	X
fnp-6282	31	25	50	50	NUM
fnp-6282	31	26	]	]	PUNCT
fnp-6282	31	27	.	.	PUNCT
fnp-6282	32	1	we	we	PRON
fnp-6282	32	2	recently	recently	ADV
fnp-6282	32	3	demonstrated	demonstrate	VERB
fnp-6282	32	4	the	the	DET
fnp-6282	32	5	presence	presence	NOUN
fnp-6282	32	6	of	of	ADP
fnp-6282	32	7	cytoophidia	cytoophidia	PROPN
fnp-6282	32	8	immunoreactive	immunoreactive	ADJ
fnp-6282	32	9	for	for	ADP
fnp-6282	32	10	inosine	inosine	NOUN
fnp-6282	32	11	monophosphate	monophosphate	NOUN
fnp-6282	32	12	dehydrogenase	dehydrogenase	NOUN
fnp-6282	32	13	(	(	PUNCT
fnp-6282	32	14	impdh	impdh	NOUN
fnp-6282	32	15	)	)	PUNCT
fnp-6282	32	16	within	within	ADP
fnp-6282	32	17	the	the	DET
fnp-6282	32	18	nuclei	nucleus	NOUN
fnp-6282	32	19	of	of	ADP
fnp-6282	32	20	neurons	neuron	NOUN
fnp-6282	32	21	in	in	ADP
fnp-6282	32	22	the	the	DET
fnp-6282	32	23	human	human	ADJ
fnp-6282	32	24	brain	brain	NOUN
fnp-6282	32	25	[	[	X
fnp-6282	32	26	63	63	NUM
fnp-6282	32	27	,	,	PUNCT
fnp-6282	32	28	64	64	NUM
fnp-6282	32	29	]	]	PUNCT
fnp-6282	32	30	.	.	PUNCT
fnp-6282	33	1	impdh	impdh	NOUN
fnp-6282	33	2	is	be	AUX
fnp-6282	33	3	the	the	DET
fnp-6282	33	4	rate	rate	NOUN
fnp-6282	33	5	-	-	PUNCT
fnp-6282	33	6	limiting	limit	VERB
fnp-6282	33	7	enzyme	enzyme	NOUN
fnp-6282	33	8	in	in	ADP
fnp-6282	33	9	the	the	DET
fnp-6282	33	10	de	de	X
fnp-6282	33	11	novo	novo	NOUN
fnp-6282	33	12	purine	purine	NOUN
fnp-6282	33	13	biosynthesis	biosynthesis	NOUN
fnp-6282	33	14	pathway	pathway	NOUN
fnp-6282	33	15	.	.	PUNCT
fnp-6282	34	1	it	it	PRON
fnp-6282	34	2	is	be	AUX
fnp-6282	34	3	encoded	encode	VERB
fnp-6282	34	4	by	by	ADP
fnp-6282	34	5	two	two	NUM
fnp-6282	34	6	genes	gene	NOUN
fnp-6282	34	7	,	,	PUNCT
fnp-6282	34	8	impdh1	impdh1	NOUN
fnp-6282	34	9	and	and	CCONJ
fnp-6282	34	10	impdh2	impdh2	VERB
fnp-6282	35	1	[	[	X
fnp-6282	35	2	48	48	NUM
fnp-6282	35	3	]	]	PUNCT
fnp-6282	35	4	.	.	PUNCT
fnp-6282	36	1	these	these	DET
fnp-6282	36	2	nuclear	nuclear	ADJ
fnp-6282	36	3	cytoophidia	cytoophidia	PROPN
fnp-6282	36	4	(	(	PUNCT
fnp-6282	36	5	ncs	ncs	PROPN
fnp-6282	36	6	)	)	PUNCT
fnp-6282	36	7	are	be	AUX
fnp-6282	36	8	also	also	ADV
fnp-6282	36	9	immunoreactive	immunoreactive	ADJ
fnp-6282	36	10	for	for	ADP
fnp-6282	36	11	the	the	DET
fnp-6282	36	12	nucleotide	nucleotide	NOUN
fnp-6282	36	13	-	-	PUNCT
fnp-6282	36	14	synthesizing	synthesize	VERB
fnp-6282	36	15	enzyme	enzyme	NOUN
fnp-6282	36	16	phosphoribosyl	phosphoribosyl	NOUN
fnp-6282	36	17	pyrophosphate	pyrophosphate	NOUN
fnp-6282	36	18	synthetase	synthetase	NOUN
fnp-6282	36	19	(	(	PUNCT
fnp-6282	36	20	prps	prps	PROPN
fnp-6282	36	21	)	)	PUNCT
fnp-6282	37	1	[	[	X
fnp-6282	37	2	50	50	NUM
fnp-6282	37	3	,	,	PUNCT
fnp-6282	37	4	63	63	NUM
fnp-6282	37	5	]	]	PUNCT
fnp-6282	37	6	.	.	PUNCT
fnp-6282	38	1	prps	prps	PROPN
fnp-6282	38	2	is	be	AUX
fnp-6282	38	3	a	a	DET
fnp-6282	38	4	key	key	ADJ
fnp-6282	38	5	enzyme	enzyme	NOUN
fnp-6282	38	6	in	in	ADP
fnp-6282	38	7	the	the	DET
fnp-6282	38	8	de	de	X
fnp-6282	38	9	novo	novo	NOUN
fnp-6282	38	10	purine	purine	NOUN
fnp-6282	38	11	biosynthesis	biosynthesis	NOUN
fnp-6282	38	12	pathway	pathway	NOUN
fnp-6282	38	13	as	as	SCONJ
fnp-6282	38	14	it	it	PRON
fnp-6282	38	15	catalyses	catalyse	VERB
fnp-6282	38	16	one	one	NUM
fnp-6282	38	17	of	of	ADP
fnp-6282	38	18	the	the	DET
fnp-6282	38	19	first	first	ADJ
fnp-6282	38	20	steps	step	NOUN
fnp-6282	38	21	;	;	PUNCT
fnp-6282	38	22	the	the	DET
fnp-6282	38	23	production	production	NOUN
fnp-6282	38	24	of	of	ADP
fnp-6282	38	25	phosphoribosyl	phosphoribosyl	ADJ
fnp-6282	38	26	pyrophosphate	pyrophosphate	NOUN
fnp-6282	38	27	(	(	PUNCT
fnp-6282	38	28	prpp	prpp	PROPN
fnp-6282	38	29	)	)	PUNCT
fnp-6282	38	30	.	.	PUNCT
fnp-6282	39	1	humans	human	NOUN
fnp-6282	39	2	contain	contain	VERB
fnp-6282	39	3	three	three	NUM
fnp-6282	39	4	isoforms	isoform	NOUN
fnp-6282	39	5	of	of	ADP
fnp-6282	39	6	prps	prps	PROPN
fnp-6282	39	7	(	(	PUNCT
fnp-6282	39	8	prps1	prps1	PROPN
fnp-6282	39	9	,	,	PUNCT
fnp-6282	39	10	2	2	NUM
fnp-6282	39	11	,	,	PUNCT
fnp-6282	39	12	and	and	CCONJ
fnp-6282	39	13	3	3	NUM
fnp-6282	39	14	)	)	PUNCT
fnp-6282	39	15	.	.	PUNCT
fnp-6282	40	1	in	in	ADP
fnp-6282	40	2	light	light	NOUN
fnp-6282	40	3	of	of	ADP
fnp-6282	40	4	evidence	evidence	NOUN
fnp-6282	40	5	for	for	ADP
fnp-6282	40	6	the	the	DET
fnp-6282	40	7	involvement	involvement	NOUN
fnp-6282	40	8	of	of	ADP
fnp-6282	40	9	nucleotide	nucleotide	ADJ
fnp-6282	40	10	metabolism	metabolism	NOUN
fnp-6282	40	11	in	in	ADP
fnp-6282	40	12	ad	ad	NOUN
fnp-6282	40	13	pathogenesis	pathogenesis	NOUN
fnp-6282	40	14	cited	cite	VERB
fnp-6282	40	15	above	above	ADV
fnp-6282	40	16	and	and	CCONJ
fnp-6282	40	17	the	the	DET
fnp-6282	40	18	important	important	ADJ
fnp-6282	40	19	role	role	NOUN
fnp-6282	40	20	of	of	ADP
fnp-6282	40	21	cytoophidia	cytoophidia	NOUN
fnp-6282	40	22	formation	formation	NOUN
fnp-6282	40	23	in	in	ADP
fnp-6282	40	24	tuning	tune	VERB
fnp-6282	40	25	metabolic	metabolic	ADJ
fnp-6282	40	26	enzymatic	enzymatic	ADJ
fnp-6282	40	27	activity	activity	NOUN
fnp-6282	40	28	,	,	PUNCT
fnp-6282	40	29	we	we	PRON
fnp-6282	40	30	were	be	AUX
fnp-6282	40	31	interested	interested	ADJ
fnp-6282	40	32	in	in	ADP
fnp-6282	40	33	determining	determine	VERB
fnp-6282	40	34	whether	whether	SCONJ
fnp-6282	40	35	there	there	PRON
fnp-6282	40	36	are	be	VERB
fnp-6282	40	37	disease	disease	NOUN
fnp-6282	40	38	-	-	PUNCT
fnp-6282	40	39	specific	specific	ADJ
fnp-6282	40	40	alterations	alteration	NOUN
fnp-6282	40	41	in	in	ADP
fnp-6282	40	42	the	the	DET
fnp-6282	40	43	formation	formation	NOUN
fnp-6282	40	44	of	of	ADP
fnp-6282	40	45	prps	prps	PROPN
fnp-6282	40	46	ncs	ncs	PROPN
fnp-6282	40	47	in	in	ADP
fnp-6282	40	48	the	the	DET
fnp-6282	40	49	ad	ad	NOUN
fnp-6282	40	50	brain	brain	NOUN
fnp-6282	40	51	.	.	PUNCT
fnp-6282	41	1	materials	material	NOUN
fnp-6282	41	2	and	and	CCONJ
fnp-6282	41	3	methods	method	NOUN
fnp-6282	41	4	participant	participant	ADJ
fnp-6282	41	5	selection	selection	NOUN
fnp-6282	41	6	subsequent	subsequent	ADJ
fnp-6282	41	7	to	to	ADP
fnp-6282	41	8	approval	approval	NOUN
fnp-6282	41	9	by	by	ADP
fnp-6282	41	10	the	the	DET
fnp-6282	41	11	ottawa	ottawa	PROPN
fnp-6282	41	12	health	health	PROPN
fnp-6282	41	13	science	science	PROPN
fnp-6282	41	14	network	network	PROPN
fnp-6282	41	15	research	research	PROPN
fnp-6282	41	16	ethics	ethic	NOUN
fnp-6282	41	17	board	board	PROPN
fnp-6282	41	18	,	,	PUNCT
fnp-6282	41	19	tissue	tissue	NOUN
fnp-6282	41	20	blocks	block	NOUN
fnp-6282	41	21	of	of	ADP
fnp-6282	41	22	formalin	formalin	NOUN
fnp-6282	41	23	-	-	PUNCT
fnp-6282	41	24	fixed	fix	VERB
fnp-6282	41	25	,	,	PUNCT
fnp-6282	41	26	paraffin	paraffin	NOUN
fnp-6282	41	27	-	-	PUNCT
fnp-6282	41	28	embedded	embed	VERB
fnp-6282	41	29	post	post	ADJ
fnp-6282	41	30	-	-	ADJ
fnp-6282	41	31	mortem	mortem	ADJ
fnp-6282	41	32	human	human	ADJ
fnp-6282	41	33	hippocampus	hippocampus	NOUN
fnp-6282	41	34	and	and	CCONJ
fnp-6282	41	35	adjacent	adjacent	ADJ
fnp-6282	41	36	parahippocampal	parahippocampal	ADJ
fnp-6282	41	37	gyrus	gyru	NOUN
fnp-6282	41	38	were	be	AUX
fnp-6282	41	39	obtained	obtain	VERB
fnp-6282	41	40	from	from	ADP
fnp-6282	41	41	the	the	DET
fnp-6282	41	42	tissue	tissue	NOUN
fnp-6282	41	43	archive	archive	NOUN
fnp-6282	41	44	in	in	ADP
fnp-6282	41	45	the	the	DET
fnp-6282	41	46	division	division	NOUN
fnp-6282	41	47	of	of	ADP
fnp-6282	41	48	anatomical	anatomical	ADJ
fnp-6282	41	49	pathology	pathology	NOUN
fnp-6282	41	50	of	of	ADP
fnp-6282	41	51	the	the	DET
fnp-6282	41	52	ottawa	ottawa	PROPN
fnp-6282	41	53	hospital	hospital	NOUN
fnp-6282	41	54	.	.	PUNCT
fnp-6282	42	1	the	the	DET
fnp-6282	42	2	cohort	cohort	NOUN
fnp-6282	42	3	included	include	VERB
fnp-6282	42	4	177	177	NUM
fnp-6282	42	5	participants	participant	NOUN
fnp-6282	42	6	including	include	VERB
fnp-6282	42	7	82	82	NUM
fnp-6282	42	8	neurologically	neurologically	ADV
fnp-6282	42	9	cognitively	cognitively	ADV
fnp-6282	42	10	unimpaired	unimpaire	VERB
fnp-6282	42	11	controls	control	NOUN
fnp-6282	42	12	,	,	PUNCT
fnp-6282	42	13	30	30	NUM
fnp-6282	42	14	with	with	ADP
fnp-6282	42	15	advanced	advanced	ADJ
fnp-6282	42	16	ad	ad	NOUN
fnp-6282	42	17	,	,	PUNCT
fnp-6282	42	18	17	17	NUM
fnp-6282	42	19	with	with	ADP
fnp-6282	42	20	lbd	lbd	PROPN
fnp-6282	42	21	(	(	PUNCT
fnp-6282	42	22	11	11	NUM
fnp-6282	42	23	diffuse	diffuse	PROPN
fnp-6282	42	24	neocortical	neocortical	ADJ
fnp-6282	42	25	,	,	PUNCT
fnp-6282	42	26	4	4	NUM
fnp-6282	42	27	limbic	limbic	NOUN
fnp-6282	42	28	/	/	SYM
fnp-6282	42	29	transitional	transitional	ADJ
fnp-6282	42	30	,	,	PUNCT
fnp-6282	42	31	2	2	NUM
fnp-6282	42	32	brainstem	brainstem	NOUN
fnp-6282	42	33	)	)	PUNCT
fnp-6282	42	34	,	,	PUNCT
fnp-6282	42	35	14	14	NUM
fnp-6282	42	36	with	with	ADP
fnp-6282	42	37	primary	primary	ADJ
fnp-6282	42	38	tauopathy	tauopathy	NOUN
fnp-6282	42	39	(	(	PUNCT
fnp-6282	42	40	11	11	NUM
fnp-6282	42	41	with	with	ADP
fnp-6282	42	42	progressive	progressive	ADJ
fnp-6282	42	43	supranuclear	supranuclear	ADJ
fnp-6282	42	44	palsy	palsy	ADJ
fnp-6282	42	45	(	(	PUNCT
fnp-6282	42	46	psp	psp	NOUN
fnp-6282	42	47	)	)	PUNCT
fnp-6282	42	48	and	and	CCONJ
fnp-6282	42	49	3	3	NUM
fnp-6282	42	50	with	with	ADP
fnp-6282	42	51	corticobasal	corticobasal	NOUN
fnp-6282	42	52	degeneration	degeneration	NOUN
fnp-6282	42	53	(	(	PUNCT
fnp-6282	42	54	cbd	cbd	NOUN
fnp-6282	42	55	)	)	PUNCT
fnp-6282	42	56	)	)	PUNCT
fnp-6282	42	57	,	,	PUNCT
fnp-6282	42	58	and	and	CCONJ
fnp-6282	42	59	an	an	DET
fnp-6282	42	60	additional	additional	ADJ
fnp-6282	42	61	6	6	NUM
fnp-6282	42	62	cognitively	cognitively	ADV
fnp-6282	42	63	intact	intact	ADJ
fnp-6282	42	64	participants	participant	NOUN
fnp-6282	42	65	with	with	ADP
fnp-6282	42	66	significant	significant	ADJ
fnp-6282	42	67	beta	beta	NOUN
fnp-6282	42	68	-	-	PUNCT
fnp-6282	42	69	amyloid	amyloid	NOUN
fnp-6282	42	70	deposition	deposition	NOUN
fnp-6282	42	71	.	.	PUNCT
fnp-6282	43	1	demographic	demographic	ADJ
fnp-6282	43	2	details	detail	NOUN
fnp-6282	43	3	regarding	regard	VERB
fnp-6282	43	4	the	the	DET
fnp-6282	43	5	participant	participant	ADJ
fnp-6282	43	6	cohort	cohort	NOUN
fnp-6282	43	7	as	as	ADV
fnp-6282	43	8	well	well	ADV
fnp-6282	43	9	as	as	ADP
fnp-6282	43	10	the	the	DET
fnp-6282	43	11	raw	raw	ADJ
fnp-6282	43	12	data	datum	NOUN
fnp-6282	43	13	are	be	AUX
fnp-6282	43	14	provided	provide	VERB
fnp-6282	43	15	in	in	ADP
fnp-6282	43	16	supplementary	supplementary	ADJ
fnp-6282	43	17	table	table	NOUN
fnp-6282	43	18	 	 	SPACE
fnp-6282	43	19	1	1	NUM
fnp-6282	43	20	.	.	PUNCT
fnp-6282	43	21	also	also	ADV
fnp-6282	43	22	included	include	VERB
fnp-6282	43	23	in	in	ADP
fnp-6282	43	24	the	the	DET
fnp-6282	43	25	table	table	NOUN
fnp-6282	43	26	are	be	AUX
fnp-6282	43	27	data	datum	NOUN
fnp-6282	43	28	indicating	indicate	VERB
fnp-6282	43	29	the	the	DET
fnp-6282	43	30	presence	presence	NOUN
fnp-6282	43	31	or	or	CCONJ
fnp-6282	43	32	absence	absence	NOUN
fnp-6282	43	33	of	of	ADP
fnp-6282	43	34	phosphorylated	phosphorylate	VERB
fnp-6282	43	35	tau	tau	PROPN
fnp-6282	43	36	(	(	PUNCT
fnp-6282	43	37	ptau	ptau	ADV
fnp-6282	43	38	)	)	PUNCT
fnp-6282	43	39	neurofibrillary	neurofibrillary	ADJ
fnp-6282	43	40	pathology	pathology	NOUN
fnp-6282	43	41	and	and	CCONJ
fnp-6282	43	42	beta	beta	NOUN
fnp-6282	43	43	-	-	PUNCT
fnp-6282	43	44	amyloid	amyloid	NOUN
fnp-6282	43	45	plaques	plaque	NOUN
fnp-6282	43	46	in	in	ADP
fnp-6282	43	47	each	each	DET
fnp-6282	43	48	tissue	tissue	NOUN
fnp-6282	43	49	core	core	NOUN
fnp-6282	43	50	.	.	PUNCT
fnp-6282	44	1	subjects	subject	NOUN
fnp-6282	44	2	were	be	AUX
fnp-6282	44	3	included	include	VERB
fnp-6282	44	4	based	base	VERB
fnp-6282	44	5	on	on	ADP
fnp-6282	44	6	retrospective	retrospective	ADJ
fnp-6282	44	7	review	review	NOUN
fnp-6282	44	8	of	of	ADP
fnp-6282	44	9	post	post	ADJ
fnp-6282	44	10	-	-	ADJ
fnp-6282	44	11	mortem	mortem	ADJ
fnp-6282	44	12	neuropathology	neuropathology	NOUN
fnp-6282	44	13	reports	report	VERB
fnp-6282	44	14	.	.	PUNCT
fnp-6282	45	1	all	all	DET
fnp-6282	45	2	post	post	ADJ
fnp-6282	45	3	-	-	ADJ
fnp-6282	45	4	mortem	mortem	ADJ
fnp-6282	45	5	neuropathological	neuropathological	ADJ
fnp-6282	45	6	diagnoses	diagnosis	NOUN
fnp-6282	45	7	were	be	AUX
fnp-6282	45	8	performed	perform	VERB
fnp-6282	45	9	by	by	ADP
fnp-6282	45	10	a	a	DET
fnp-6282	45	11	neuropathologist	neuropathologist	ADJ
fnp-6282	45	12	(	(	PUNCT
fnp-6282	45	13	jw	jw	PROPN
fnp-6282	45	14	)	)	PUNCT
fnp-6282	45	15	according	accord	VERB
fnp-6282	45	16	to	to	ADP
fnp-6282	45	17	current	current	ADJ
fnp-6282	45	18	diagnostic	diagnostic	ADJ
fnp-6282	45	19	and	and	CCONJ
fnp-6282	45	20	staging	staging	NOUN
fnp-6282	45	21	criteria	criterion	NOUN
fnp-6282	45	22	[	[	X
fnp-6282	45	23	4	4	NUM
fnp-6282	45	24	,	,	PUNCT
fnp-6282	45	25	18	18	NUM
fnp-6282	45	26	,	,	PUNCT
fnp-6282	45	27	36	36	NUM
fnp-6282	45	28	,	,	PUNCT
fnp-6282	45	29	47	47	NUM
fnp-6282	45	30	]	]	PUNCT
fnp-6282	45	31	.	.	PUNCT
fnp-6282	46	1	specifically	specifically	ADV
fnp-6282	46	2	,	,	PUNCT
fnp-6282	46	3	ad	ad	NOUN
fnp-6282	46	4	neuropathologic	neuropathologic	NOUN
fnp-6282	46	5	change	change	NOUN
fnp-6282	46	6	(	(	PUNCT
fnp-6282	46	7	adnc	adnc	ADJ
fnp-6282	46	8	)	)	PUNCT
fnp-6282	46	9	was	be	AUX
fnp-6282	46	10	diagnosed	diagnose	VERB
fnp-6282	46	11	based	base	VERB
fnp-6282	46	12	on	on	ADP
fnp-6282	46	13	the	the	DET
fnp-6282	46	14	combined	combine	VERB
fnp-6282	46	15	analysis	analysis	NOUN
fnp-6282	46	16	of	of	ADP
fnp-6282	46	17	cortical	cortical	ADJ
fnp-6282	46	18	beta	beta	ADJ
fnp-6282	46	19	amyloid	amyloid	NOUN
fnp-6282	46	20	burden	burden	NOUN
fnp-6282	46	21	according	accord	VERB
fnp-6282	46	22	to	to	ADP
fnp-6282	46	23	the	the	DET
fnp-6282	46	24	thal	thal	NOUN
fnp-6282	46	25	staging	staging	NOUN
fnp-6282	46	26	scheme	scheme	NOUN
fnp-6282	46	27	[	[	X
fnp-6282	46	28	60	60	NUM
fnp-6282	46	29	]	]	PUNCT
fnp-6282	46	30	,	,	PUNCT
fnp-6282	46	31	braak	braak	NOUN
fnp-6282	46	32	neurofibrillary	neurofibrillary	ADJ
fnp-6282	46	33	stage	stage	NOUN
fnp-6282	47	1	[	[	X
fnp-6282	47	2	9	9	NUM
fnp-6282	47	3	]	]	PUNCT
fnp-6282	47	4	,	,	PUNCT
fnp-6282	47	5	and	and	CCONJ
fnp-6282	47	6	cortical	cortical	ADJ
fnp-6282	47	7	neuritic	neuritic	ADJ
fnp-6282	47	8	plaque	plaque	NOUN
fnp-6282	47	9	density	density	NOUN
fnp-6282	47	10	following	follow	VERB
fnp-6282	47	11	consortium	consortium	NOUN
fnp-6282	47	12	to	to	PART
fnp-6282	47	13	establish	establish	VERB
fnp-6282	47	14	a	a	DET
fnp-6282	47	15	registry	registry	NOUN
fnp-6282	47	16	for	for	ADP
fnp-6282	47	17	alzheimer	alzheimer	PROPN
fnp-6282	47	18	’s	’s	PART
fnp-6282	47	19	disease	disease	NOUN
fnp-6282	47	20	(	(	PUNCT
fnp-6282	47	21	cerad	cerad	NOUN
fnp-6282	47	22	)	)	PUNCT
fnp-6282	47	23	criteria	criterion	NOUN
fnp-6282	47	24	[	[	X
fnp-6282	47	25	45	45	NUM
fnp-6282	47	26	]	]	PUNCT
fnp-6282	47	27	to	to	PART
fnp-6282	47	28	arrive	arrive	VERB
fnp-6282	47	29	at	at	ADP
fnp-6282	47	30	an	an	DET
fnp-6282	47	31	"	"	PUNCT
fnp-6282	47	32	abc	abc	PROPN
fnp-6282	47	33	"	"	PUNCT
fnp-6282	47	34	score	score	NOUN
fnp-6282	47	35	as	as	ADP
fnp-6282	47	36	per	per	ADP
fnp-6282	47	37	the	the	DET
fnp-6282	47	38	national	national	PROPN
fnp-6282	47	39	institute	institute	PROPN
fnp-6282	47	40	on	on	ADP
fnp-6282	47	41	aging	age	VERB
fnp-6282	47	42	-	-	PUNCT
fnp-6282	47	43	alzheimer	alzheimer	NOUN
fnp-6282	47	44	's	's	PART
fnp-6282	47	45	association	association	NOUN
fnp-6282	47	46	guidelines	guideline	NOUN
fnp-6282	47	47	for	for	ADP
fnp-6282	47	48	the	the	DET
fnp-6282	47	49	neuropathologic	neuropathologic	ADJ
fnp-6282	47	50	assessment	assessment	NOUN
fnp-6282	47	51	of	of	ADP
fnp-6282	47	52	alzheimer	alzheimer	PROPN
fnp-6282	47	53	's	's	PART
fnp-6282	47	54	disease	disease	NOUN
fnp-6282	48	1	[	[	X
fnp-6282	48	2	47	47	NUM
fnp-6282	48	3	]	]	PUNCT
fnp-6282	48	4	(	(	PUNCT
fnp-6282	48	5	see	see	VERB
fnp-6282	48	6	supplementary	supplementary	ADJ
fnp-6282	48	7	table	table	NOUN
fnp-6282	48	8	 	 	SPACE
fnp-6282	48	9	1	1	NUM
fnp-6282	48	10	)	)	PUNCT
fnp-6282	48	11	.	.	PUNCT
fnp-6282	49	1	a	a	DET
fnp-6282	49	2	proportion	proportion	NOUN
fnp-6282	49	3	of	of	ADP
fnp-6282	49	4	cases	case	NOUN
fnp-6282	49	5	were	be	AUX
fnp-6282	49	6	diagnosed	diagnose	VERB
fnp-6282	49	7	prior	prior	ADV
fnp-6282	49	8	to	to	ADP
fnp-6282	49	9	publication	publication	NOUN
fnp-6282	49	10	of	of	ADP
fnp-6282	49	11	these	these	DET
fnp-6282	49	12	guidelines	guideline	NOUN
fnp-6282	49	13	and	and	CCONJ
fnp-6282	49	14	only	only	ADV
fnp-6282	49	15	those	those	PRON
fnp-6282	49	16	receiving	receive	VERB
fnp-6282	49	17	a	a	DET
fnp-6282	49	18	diagnosis	diagnosis	NOUN
fnp-6282	49	19	of	of	ADP
fnp-6282	49	20	"	"	PUNCT
fnp-6282	49	21	severe	severe	ADJ
fnp-6282	49	22	"	"	PUNCT
fnp-6282	49	23	ad	ad	NOUN
fnp-6282	49	24	or	or	CCONJ
fnp-6282	49	25	a	a	DET
fnp-6282	49	26	braak	braak	NOUN
fnp-6282	49	27	score	score	NOUN
fnp-6282	49	28	of	of	ADP
fnp-6282	49	29	v	v	NUM
fnp-6282	49	30	or	or	CCONJ
fnp-6282	49	31	vi	vi	PROPN
fnp-6282	49	32	were	be	AUX
fnp-6282	49	33	included	include	VERB
fnp-6282	49	34	among	among	ADP
fnp-6282	49	35	the	the	DET
fnp-6282	49	36	ad	ad	NOUN
fnp-6282	49	37	cohort	cohort	NOUN
fnp-6282	49	38	.	.	PUNCT
fnp-6282	50	1	a	a	DET
fnp-6282	50	2	proportion	proportion	NOUN
fnp-6282	50	3	of	of	ADP
fnp-6282	50	4	cognitively	cognitively	ADV
fnp-6282	50	5	normal	normal	ADJ
fnp-6282	50	6	controls	control	NOUN
fnp-6282	50	7	were	be	AUX
fnp-6282	50	8	assessed	assess	VERB
fnp-6282	50	9	for	for	ADP
fnp-6282	50	10	adnc	adnc	ADJ
fnp-6282	50	11	and	and	CCONJ
fnp-6282	50	12	only	only	ADV
fnp-6282	50	13	those	those	PRON
fnp-6282	50	14	with	with	ADP
fnp-6282	50	15	"	"	PUNCT
fnp-6282	50	16	mild	mild	ADJ
fnp-6282	50	17	"	"	PUNCT
fnp-6282	50	18	changes	change	NOUN
fnp-6282	50	19	were	be	AUX
fnp-6282	50	20	included	include	VERB
fnp-6282	50	21	.	.	PUNCT
fnp-6282	51	1	tissue	tissue	NOUN
fnp-6282	51	2	microarray	microarray	NOUN
fnp-6282	51	3	preparation	preparation	NOUN
fnp-6282	51	4	and	and	CCONJ
fnp-6282	51	5	immunostaining	immunostaine	VERB
fnp-6282	51	6	from	from	ADP
fnp-6282	51	7	each	each	PRON
fnp-6282	51	8	of	of	ADP
fnp-6282	51	9	the	the	DET
fnp-6282	51	10	paraffin	paraffin	NOUN
fnp-6282	51	11	blocks	block	NOUN
fnp-6282	51	12	of	of	ADP
fnp-6282	51	13	hippocampus	hippocampus	NOUN
fnp-6282	51	14	and	and	CCONJ
fnp-6282	51	15	mesial	mesial	ADJ
fnp-6282	51	16	temporal	temporal	ADJ
fnp-6282	51	17	cortex	cortex	NOUN
fnp-6282	51	18	,	,	PUNCT
fnp-6282	51	19	tissue	tissue	NOUN
fnp-6282	51	20	microarrays	microarray	NOUN
fnp-6282	51	21	(	(	PUNCT
fnp-6282	51	22	tmas	tmas	X
fnp-6282	51	23	)	)	PUNCT
fnp-6282	51	24	were	be	AUX
fnp-6282	51	25	prepared	prepare	VERB
fnp-6282	51	26	using	use	VERB
fnp-6282	51	27	2	2	NUM
fnp-6282	51	28	 	 	SPACE
fnp-6282	51	29	mm	mm	PROPN
fnp-6282	51	30	punches	punch	NOUN
fnp-6282	51	31	centered	center	VERB
fnp-6282	51	32	on	on	ADP
fnp-6282	51	33	the	the	DET
fnp-6282	51	34	temporal	temporal	ADJ
fnp-6282	51	35	cortex	cortex	NOUN
fnp-6282	51	36	at	at	ADP
fnp-6282	51	37	the	the	DET
fnp-6282	51	38	depth	depth	NOUN
fnp-6282	51	39	of	of	ADP
fnp-6282	51	40	the	the	DET
fnp-6282	51	41	collateral	collateral	ADJ
fnp-6282	51	42	sulcus	sulcus	NOUN
fnp-6282	51	43	.	.	PUNCT
fnp-6282	52	1	this	this	DET
fnp-6282	52	2	area	area	NOUN
fnp-6282	52	3	was	be	AUX
fnp-6282	52	4	selected	select	VERB
fnp-6282	52	5	because	because	SCONJ
fnp-6282	52	6	it	it	PRON
fnp-6282	52	7	consistently	consistently	ADV
fnp-6282	52	8	displays	display	VERB
fnp-6282	52	9	ncs	ncs	PROPN
fnp-6282	52	10	in	in	ADP
fnp-6282	52	11	control	control	NOUN
fnp-6282	52	12	brains	brain	NOUN
fnp-6282	52	13	and	and	CCONJ
fnp-6282	52	14	because	because	SCONJ
fnp-6282	52	15	it	it	PRON
fnp-6282	52	16	was	be	AUX
fnp-6282	52	17	the	the	DET
fnp-6282	52	18	area	area	NOUN
fnp-6282	52	19	we	we	PRON
fnp-6282	52	20	analysed	analyse	VERB
fnp-6282	52	21	in	in	ADP
fnp-6282	52	22	our	our	PRON
fnp-6282	52	23	previous	previous	ADJ
fnp-6282	52	24	study	study	NOUN
fnp-6282	52	25	[	[	X
fnp-6282	52	26	65	65	NUM
fnp-6282	52	27	]	]	PUNCT
fnp-6282	52	28	.	.	PUNCT
fnp-6282	53	1	tmas	tmas	PROPN
fnp-6282	53	2	were	be	AUX
fnp-6282	53	3	sectioned	section	VERB
fnp-6282	53	4	at	at	ADP
fnp-6282	53	5	a	a	DET
fnp-6282	53	6	thickness	thickness	NOUN
fnp-6282	53	7	of	of	ADP
fnp-6282	53	8	5	5	NUM
fnp-6282	53	9	 	 	SPACE
fnp-6282	53	10	μm	μm	NOUN
fnp-6282	53	11	and	and	CCONJ
fnp-6282	53	12	mounted	mount	VERB
fnp-6282	53	13	onto	onto	ADP
fnp-6282	53	14	coated	coated	ADJ
fnp-6282	53	15	slides	slide	NOUN
fnp-6282	53	16	.	.	PUNCT
fnp-6282	54	1	sections	section	NOUN
fnp-6282	54	2	were	be	AUX
fnp-6282	54	3	deparaffinized	deparaffinize	VERB
fnp-6282	54	4	and	and	CCONJ
fnp-6282	54	5	pre	pre	VERB
fnp-6282	54	6	-	-	ADJ
fnp-6282	54	7	treated	treat	VERB
fnp-6282	54	8	using	use	VERB
fnp-6282	54	9	heat	heat	NOUN
fnp-6282	54	10	mediated	mediate	VERB
fnp-6282	54	11	antigen	antigen	ADJ
fnp-6282	54	12	retrieval	retrieval	NOUN
fnp-6282	54	13	with	with	ADP
fnp-6282	54	14	edta	edta	NOUN
fnp-6282	54	15	buffer	buffer	NOUN
fnp-6282	54	16	(	(	PUNCT
fnp-6282	54	17	ph	ph	NOUN
fnp-6282	54	18	9.0	9.0	NUM
fnp-6282	54	19	)	)	PUNCT
fnp-6282	54	20	.	.	PUNCT
fnp-6282	55	1	slides	slide	NOUN
fnp-6282	55	2	were	be	AUX
fnp-6282	55	3	then	then	ADV
fnp-6282	55	4	rehydrated	rehydrate	VERB
fnp-6282	55	5	in	in	ADP
fnp-6282	55	6	1x	1x	NUM
fnp-6282	55	7	tbst	tbst	NOUN
fnp-6282	55	8	buffer	buffer	NOUN
fnp-6282	55	9	and	and	CCONJ
fnp-6282	55	10	blocked	block	VERB
fnp-6282	55	11	for	for	ADP
fnp-6282	55	12	30	30	NUM
fnp-6282	55	13	 	 	SPACE
fnp-6282	55	14	min	min	NOUN
fnp-6282	55	15	with	with	ADP
fnp-6282	55	16	sniper	sniper	NOUN
fnp-6282	55	17	(	(	PUNCT
fnp-6282	55	18	#	#	SYM
fnp-6282	55	19	biocare	biocare	NOUN
fnp-6282	55	20	bs966l	bs966l	NUM
fnp-6282	55	21	)	)	PUNCT
fnp-6282	55	22	.	.	PUNCT
fnp-6282	56	1	sections	section	NOUN
fnp-6282	56	2	were	be	AUX
fnp-6282	56	3	stained	stain	VERB
fnp-6282	56	4	using	use	VERB
fnp-6282	56	5	dual	dual	ADJ
fnp-6282	56	6	labelling	labelling	NOUN
fnp-6282	56	7	immunofluorescence	immunofluorescence	NOUN
fnp-6282	56	8	by	by	ADP
fnp-6282	56	9	incubating	incubate	VERB
fnp-6282	56	10	overnight	overnight	ADV
fnp-6282	56	11	at	at	ADP
fnp-6282	56	12	4	4	NUM
fnp-6282	56	13	degrees	degree	NOUN
fnp-6282	56	14	in	in	ADP
fnp-6282	56	15	a	a	DET
fnp-6282	56	16	cocktail	cocktail	NOUN
fnp-6282	56	17	of	of	ADP
fnp-6282	56	18	antibodies	antibody	NOUN
fnp-6282	56	19	against	against	ADP
fnp-6282	56	20	prps	prps	PROPN
fnp-6282	56	21	(	(	PUNCT
fnp-6282	56	22	rabbit	rabbit	NOUN
fnp-6282	56	23	polyclonal	polyclonal	NOUN
fnp-6282	56	24	;	;	PUNCT
fnp-6282	56	25	1:100	1:100	NUM
fnp-6282	56	26	,	,	PUNCT
fnp-6282	56	27	proteintech	proteintech	NOUN
fnp-6282	56	28	15549	15549	NUM
fnp-6282	56	29	-	-	SYM
fnp-6282	56	30	1	1	NUM
fnp-6282	56	31	-	-	PUNCT
fnp-6282	56	32	ap	ap	NOUN
fnp-6282	56	33	)	)	PUNCT
fnp-6282	56	34	and	and	CCONJ
fnp-6282	56	35	the	the	DET
fnp-6282	56	36	neuronal	neuronal	ADJ
fnp-6282	56	37	marker	marker	NOUN
fnp-6282	56	38	microtubule	microtubule	NOUN
fnp-6282	56	39	-	-	PUNCT
fnp-6282	56	40	associated	associate	VERB
fnp-6282	56	41	protein	protein	NOUN
fnp-6282	56	42	2	2	NUM
fnp-6282	56	43	(	(	PUNCT
fnp-6282	56	44	map2	map2	NOUN
fnp-6282	56	45	;	;	PUNCT
fnp-6282	56	46	mouse	mouse	NOUN
fnp-6282	56	47	monoclonal	monoclonal	NOUN
fnp-6282	56	48	;	;	PUNCT
fnp-6282	56	49	clone	clone	NOUN
fnp-6282	56	50	b-8	b-8	PROPN
fnp-6282	56	51	;	;	PUNCT
fnp-6282	56	52	santa	santa	PROPN
fnp-6282	56	53	cruz	cruz	PROPN
fnp-6282	56	54	biotechnology	biotechnology	PROPN
fnp-6282	56	55	sc-74420	sc-74420	PROPN
fnp-6282	56	56	)	)	PUNCT
fnp-6282	56	57	or	or	CCONJ
fnp-6282	56	58	ptau	ptau	ADV
fnp-6282	56	59	(	(	PUNCT
fnp-6282	56	60	mouse	mouse	NOUN
fnp-6282	56	61	monoclonal	monoclonal	NOUN
fnp-6282	56	62	;	;	PUNCT
fnp-6282	56	63	1:100	1:100	NUM
fnp-6282	56	64	,	,	PUNCT
fnp-6282	56	65	thermofisher	thermofisher	ADJ
fnp-6282	56	66	#	#	SYM
fnp-6282	56	67	mn1020	mn1020	NOUN
fnp-6282	56	68	)	)	PUNCT
fnp-6282	56	69	.	.	PUNCT
fnp-6282	57	1	sections	section	NOUN
fnp-6282	57	2	were	be	AUX
fnp-6282	57	3	washed	wash	VERB
fnp-6282	57	4	with	with	ADP
fnp-6282	57	5	1x	1x	PROPN
fnp-6282	57	6	tbst	tbst	PROPN
fnp-6282	57	7	and	and	CCONJ
fnp-6282	57	8	then	then	ADV
fnp-6282	57	9	incubated	incubate	VERB
fnp-6282	57	10	with	with	ADP
fnp-6282	57	11	goat	goat	PROPN
fnp-6282	57	12	anti	anti	PROPN
fnp-6282	57	13	-	-	NOUN
fnp-6282	57	14	mouse	mouse	ADJ
fnp-6282	57	15	594	594	NUM
fnp-6282	57	16	(	(	PUNCT
fnp-6282	57	17	#	#	NOUN
fnp-6282	57	18	a11005	a11005	PROPN
fnp-6282	57	19	,	,	PUNCT
fnp-6282	57	20	invitrogen	invitrogen	PROPN
fnp-6282	57	21	)	)	PUNCT
fnp-6282	57	22	and	and	CCONJ
fnp-6282	57	23	donkey	donkey	NOUN
fnp-6282	57	24	anti	anti	ADJ
fnp-6282	57	25	-	-	NOUN
fnp-6282	57	26	rabbit	rabbit	ADJ
fnp-6282	57	27	488	488	NUM
fnp-6282	57	28	(	(	PUNCT
fnp-6282	57	29	#	#	SYM
fnp-6282	57	30	a21206	a21206	PROPN
fnp-6282	57	31	)	)	PUNCT
fnp-6282	57	32	secondary	secondary	ADJ
fnp-6282	57	33	antibodies	antibody	NOUN
fnp-6282	57	34	for	for	ADP
fnp-6282	57	35	2	2	NUM
fnp-6282	57	36	 	 	SPACE
fnp-6282	57	37	h	h	NOUN
fnp-6282	57	38	in	in	ADP
fnp-6282	57	39	the	the	DET
fnp-6282	57	40	dark	dark	NOUN
fnp-6282	57	41	at	at	ADP
fnp-6282	57	42	room	room	NOUN
fnp-6282	57	43	temperature	temperature	NOUN
fnp-6282	57	44	.	.	PUNCT
fnp-6282	58	1	this	this	PRON
fnp-6282	58	2	was	be	AUX
fnp-6282	58	3	followed	follow	VERB
fnp-6282	58	4	by	by	ADP
fnp-6282	58	5	incubation	incubation	NOUN
fnp-6282	58	6	with	with	ADP
fnp-6282	58	7	a	a	DET
fnp-6282	58	8	quencher	quencher	NOUN
fnp-6282	58	9	(	(	PUNCT
fnp-6282	58	10	vector	vector	NOUN
fnp-6282	58	11	trueview	trueview	NOUN
fnp-6282	58	12	autofluorescence	autofluorescence	NOUN
fnp-6282	58	13	quenching	quenching	NOUN
fnp-6282	58	14	kit	kit	NOUN
fnp-6282	58	15	#	#	NOUN
fnp-6282	58	16	sp-8400	sp-8400	NOUN
fnp-6282	58	17	,	,	PUNCT
fnp-6282	58	18	vector	vector	NOUN
fnp-6282	58	19	labs	lab	NOUN
fnp-6282	58	20	)	)	PUNCT
fnp-6282	58	21	to	to	PART
fnp-6282	58	22	decrease	decrease	VERB
fnp-6282	58	23	autofluorescence	autofluorescence	NOUN
fnp-6282	58	24	.	.	PUNCT
fnp-6282	59	1	sections	section	NOUN
fnp-6282	59	2	were	be	AUX
fnp-6282	59	3	washed	wash	VERB
fnp-6282	59	4	,	,	PUNCT
fnp-6282	59	5	incubated	incubate	VERB
fnp-6282	59	6	with	with	ADP
fnp-6282	59	7	5	5	NUM
fnp-6282	59	8	 	 	SPACE
fnp-6282	59	9	ug	ug	ADP
fnp-6282	59	10	/	/	SYM
fnp-6282	59	11	ml	ml	PROPN
fnp-6282	59	12	of	of	ADP
fnp-6282	59	13	dapi	dapi	ADJ
fnp-6282	59	14	(	(	PUNCT
fnp-6282	59	15	thermoscientific	thermoscientific	NOUN
fnp-6282	59	16	#	#	SYM
fnp-6282	59	17	62248	62248	NUM
fnp-6282	59	18	)	)	PUNCT
fnp-6282	59	19	and	and	CCONJ
fnp-6282	59	20	coverslipped	coverslippe	VERB
fnp-6282	59	21	.	.	PUNCT
fnp-6282	60	1	image	image	NOUN
fnp-6282	60	2	and	and	CCONJ
fnp-6282	60	3	data	datum	NOUN
fnp-6282	60	4	analysis	analysis	NOUN
fnp-6282	60	5	images	image	NOUN
fnp-6282	60	6	were	be	AUX
fnp-6282	60	7	acquired	acquire	VERB
fnp-6282	60	8	using	use	VERB
fnp-6282	60	9	a	a	DET
fnp-6282	60	10	zeiss	zeiss	PROPN
fnp-6282	60	11	axioimager	axioimager	NOUN
fnp-6282	60	12	m2	m2	PROPN
fnp-6282	60	13	microscope	microscope	NOUN
fnp-6282	60	14	.	.	PUNCT
fnp-6282	61	1	to	to	PART
fnp-6282	61	2	quantify	quantify	VERB
fnp-6282	61	3	ncs	ncs	PROPN
fnp-6282	61	4	,	,	PUNCT
fnp-6282	61	5	prps	prps	PROPN
fnp-6282	61	6	/	/	SYM
fnp-6282	61	7	map2	map2	PROPN
fnp-6282	61	8	stained	stain	VERB
fnp-6282	61	9	tmas	tma	NOUN
fnp-6282	61	10	were	be	AUX
fnp-6282	61	11	scanned	scan	VERB
fnp-6282	61	12	using	use	VERB
fnp-6282	61	13	a	a	DET
fnp-6282	61	14	zeiss	zeiss	PROPN
fnp-6282	61	15	m1	m1	PROPN
fnp-6282	61	16	slide	slide	NOUN
fnp-6282	61	17	scanner	scanner	NOUN
fnp-6282	61	18	.	.	PUNCT
fnp-6282	62	1	image	image	NOUN
fnp-6282	62	2	analysis	analysis	NOUN
fnp-6282	62	3	was	be	AUX
fnp-6282	62	4	performed	perform	VERB
fnp-6282	62	5	on	on	ADP
fnp-6282	62	6	digital	digital	ADJ
fnp-6282	62	7	images	image	NOUN
fnp-6282	62	8	using	use	VERB
fnp-6282	62	9	highplex	highplex	PROPN
fnp-6282	62	10	fl	fl	PROPN
fnp-6282	62	11	module	module	NOUN
fnp-6282	62	12	in	in	ADP
fnp-6282	62	13	halo	halo	NOUN
fnp-6282	62	14	software	software	NOUN
fnp-6282	62	15	as	as	ADV
fnp-6282	62	16	well	well	ADV
fnp-6282	62	17	as	as	ADP
fnp-6282	62	18	zeiss	zeiss	PROPN
fnp-6282	62	19	zen	zen	PROPN
fnp-6282	62	20	blue	blue	ADJ
fnp-6282	62	21	software	software	NOUN
fnp-6282	62	22	.	.	PUNCT
fnp-6282	63	1	the	the	DET
fnp-6282	63	2	number	number	NOUN
fnp-6282	63	3	of	of	ADP
fnp-6282	63	4	map2	map2	NOUN
fnp-6282	63	5	-	-	PUNCT
fnp-6282	63	6	immunoreactive	immunoreactive	ADJ
fnp-6282	63	7	cells	cell	NOUN
fnp-6282	63	8	containing	contain	VERB
fnp-6282	63	9	ncs	nc	NOUN
fnp-6282	63	10	in	in	ADP
fnp-6282	63	11	each	each	DET
fnp-6282	63	12	core	core	NOUN
fnp-6282	63	13	was	be	AUX
fnp-6282	63	14	counted	count	VERB
fnp-6282	63	15	manually	manually	ADV
fnp-6282	63	16	.	.	PUNCT
fnp-6282	64	1	cases	case	NOUN
fnp-6282	64	2	with	with	ADP
fnp-6282	64	3	less	less	ADJ
fnp-6282	64	4	than	than	ADP
fnp-6282	64	5	10	10	NUM
fnp-6282	64	6	neurons	neuron	NOUN
fnp-6282	64	7	per	per	ADP
fnp-6282	64	8	core	core	NOUN
fnp-6282	64	9	were	be	AUX
fnp-6282	64	10	eliminated	eliminate	VERB
fnp-6282	64	11	.	.	PUNCT
fnp-6282	65	1	all	all	DET
fnp-6282	65	2	statistical	statistical	ADJ
fnp-6282	65	3	analyses	analysis	NOUN
fnp-6282	65	4	for	for	ADP
fnp-6282	65	5	multiple	multiple	ADJ
fnp-6282	65	6	group	group	NOUN
fnp-6282	65	7	comparisons	comparison	NOUN
fnp-6282	65	8	were	be	AUX
fnp-6282	65	9	conducted	conduct	VERB
fnp-6282	65	10	using	use	VERB
fnp-6282	65	11	one	one	NUM
fnp-6282	65	12	-	-	PUNCT
fnp-6282	65	13	way	way	NOUN
fnp-6282	65	14	anova	anova	PROPN
fnp-6282	65	15	followed	follow	VERB
fnp-6282	65	16	by	by	ADP
fnp-6282	65	17	bonferroni	bonferroni	PROPN
fnp-6282	65	18	’s	’s	PART
fnp-6282	65	19	multiple	multiple	ADJ
fnp-6282	65	20	comparisons	comparison	NOUN
fnp-6282	65	21	test	test	NOUN
fnp-6282	65	22	at	at	ADP
fnp-6282	65	23	α	α	NOUN
fnp-6282	65	24	 	 	SPACE
fnp-6282	65	25	=	=	NOUN
fnp-6282	65	26	 	 	SPACE
fnp-6282	65	27	0.05	0.05	NUM
fnp-6282	65	28	significance	significance	NOUN
fnp-6282	65	29	.	.	PUNCT
fnp-6282	66	1	percentage	percentage	NOUN
fnp-6282	66	2	of	of	ADP
fnp-6282	66	3	ncs	ncs	NOUN
fnp-6282	66	4	present	present	ADJ
fnp-6282	66	5	in	in	ADP
fnp-6282	66	6	aggregate	aggregate	NOUN
fnp-6282	66	7	with	with	ADP
fnp-6282	66	8	nfts	nft	NOUN
fnp-6282	66	9	was	be	AUX
fnp-6282	66	10	determined	determine	VERB
fnp-6282	66	11	by	by	ADP
fnp-6282	66	12	manual	manual	ADJ
fnp-6282	66	13	count	count	NOUN
fnp-6282	66	14	.	.	PUNCT
fnp-6282	67	1	chi	chi	ADJ
fnp-6282	67	2	-	-	PUNCT
fnp-6282	67	3	square	square	ADJ
fnp-6282	67	4	test	test	NOUN
fnp-6282	67	5	at	at	ADP
fnp-6282	67	6	α	α	NOUN
fnp-6282	67	7	 	 	SPACE
fnp-6282	67	8	=	=	NOUN
fnp-6282	67	9	0.05	0.05	NUM
fnp-6282	67	10	significance	significance	NOUN
fnp-6282	67	11	was	be	AUX
fnp-6282	67	12	used	use	VERB
fnp-6282	67	13	to	to	PART
fnp-6282	67	14	determine	determine	VERB
fnp-6282	67	15	whether	whether	SCONJ
fnp-6282	67	16	there	there	PRON
fnp-6282	67	17	was	be	VERB
fnp-6282	67	18	any	any	DET
fnp-6282	67	19	association	association	NOUN
fnp-6282	67	20	between	between	ADP
fnp-6282	67	21	the	the	DET
fnp-6282	67	22	presence	presence	NOUN
fnp-6282	67	23	of	of	ADP
fnp-6282	67	24	ncs	ncs	NOUN
fnp-6282	67	25	and	and	CCONJ
fnp-6282	67	26	nfts	nft	NOUN
fnp-6282	67	27	.	.	PUNCT
fnp-6282	68	1	to	to	PART
fnp-6282	68	2	assess	assess	VERB
fnp-6282	68	3	beta	beta	NOUN
fnp-6282	68	4	-	-	PUNCT
fnp-6282	68	5	amyloid	amyloid	NOUN
fnp-6282	68	6	pathology	pathology	NOUN
fnp-6282	68	7	in	in	ADP
fnp-6282	68	8	each	each	DET
fnp-6282	68	9	core	core	NOUN
fnp-6282	68	10	,	,	PUNCT
fnp-6282	68	11	the	the	DET
fnp-6282	68	12	tmas	tma	NOUN
fnp-6282	68	13	were	be	AUX
fnp-6282	68	14	stained	stain	VERB
fnp-6282	68	15	using	use	VERB
fnp-6282	68	16	immunohistochemistry	immunohistochemistry	NOUN
fnp-6282	68	17	for	for	ADP
fnp-6282	68	18	the	the	DET
fnp-6282	68	19	detection	detection	NOUN
fnp-6282	68	20	of	of	ADP
fnp-6282	68	21	beta	beta	NOUN
fnp-6282	68	22	-	-	PUNCT
fnp-6282	68	23	amyloid	amyloid	NOUN
fnp-6282	68	24	(	(	PUNCT
fnp-6282	68	25	rabbit	rabbit	NOUN
fnp-6282	68	26	polyclonal	polyclonal	ADJ
fnp-6282	68	27	anti	anti	ADJ
fnp-6282	68	28	-	-	ADJ
fnp-6282	68	29	beta	beta	ADJ
fnp-6282	68	30	-	-	PUNCT
fnp-6282	68	31	amyloid	amyloid	NOUN
fnp-6282	68	32	;	;	PUNCT
fnp-6282	68	33	1:400	1:400	NUM
fnp-6282	68	34	,	,	PUNCT
fnp-6282	68	35	novus	novus	NOUN
fnp-6282	68	36	nbp2	nbp2	PROPN
fnp-6282	68	37	-	-	PUNCT
fnp-6282	68	38	13075	13075	NUM
fnp-6282	68	39	)	)	PUNCT
fnp-6282	68	40	.	.	PUNCT
fnp-6282	69	1	staining	stain	VERB
fnp-6282	69	2	was	be	AUX
fnp-6282	69	3	performed	perform	VERB
fnp-6282	69	4	using	use	VERB
fnp-6282	69	5	the	the	DET
fnp-6282	69	6	leica	leica	PROPN
fnp-6282	69	7	bond	bond	NOUN
fnp-6282	69	8	™	™	ADJ
fnp-6282	69	9	system	system	NOUN
fnp-6282	69	10	.	.	PUNCT
fnp-6282	70	1	tmas	tmas	PROPN
fnp-6282	70	2	were	be	AUX
fnp-6282	70	3	pre	pre	ADJ
fnp-6282	70	4	-	-	VERB
fnp-6282	70	5	treated	treat	VERB
fnp-6282	70	6	using	use	VERB
fnp-6282	70	7	heat	heat	NOUN
fnp-6282	70	8	mediated	mediate	VERB
fnp-6282	70	9	antigen	antigen	ADJ
fnp-6282	70	10	retrieval	retrieval	NOUN
fnp-6282	70	11	with	with	ADP
fnp-6282	70	12	edta	edta	NOUN
fnp-6282	70	13	buffer	buffer	NOUN
fnp-6282	70	14	(	(	PUNCT
fnp-6282	70	15	ph	ph	NOUN
fnp-6282	70	16	9.0	9.0	NUM
fnp-6282	70	17	,	,	PUNCT
fnp-6282	70	18	epitope	epitope	NOUN
fnp-6282	70	19	retrieval	retrieval	NOUN
fnp-6282	70	20	solution	solution	NOUN
fnp-6282	70	21	2	2	NUM
fnp-6282	70	22	)	)	PUNCT
fnp-6282	70	23	for	for	ADP
fnp-6282	70	24	20	20	NUM
fnp-6282	70	25	minutes	minute	NOUN
fnp-6282	70	26	.	.	PUNCT
fnp-6282	71	1	the	the	DET
fnp-6282	71	2	tmas	tma	NOUN
fnp-6282	71	3	were	be	AUX
fnp-6282	71	4	then	then	ADV
fnp-6282	71	5	incubated	incubate	VERB
fnp-6282	71	6	in	in	ADP
fnp-6282	71	7	primary	primary	ADJ
fnp-6282	71	8	antibody	antibody	NOUN
fnp-6282	71	9	for	for	ADP
fnp-6282	71	10	30	30	NUM
fnp-6282	71	11	minutes	minute	NOUN
fnp-6282	71	12	at	at	ADP
fnp-6282	71	13	room	room	NOUN
fnp-6282	71	14	temperature	temperature	NOUN
fnp-6282	71	15	and	and	CCONJ
fnp-6282	71	16	detected	detect	VERB
fnp-6282	71	17	using	use	VERB
fnp-6282	71	18	an	an	DET
fnp-6282	71	19	hrp	hrp	NOUN
fnp-6282	71	20	conjugated	conjugate	VERB
fnp-6282	71	21	compact	compact	ADJ
fnp-6282	71	22	polymer	polymer	NOUN
fnp-6282	71	23	system	system	NOUN
fnp-6282	71	24	.	.	PUNCT
fnp-6282	72	1	slides	slide	NOUN
fnp-6282	72	2	were	be	AUX
fnp-6282	72	3	then	then	ADV
fnp-6282	72	4	stained	stain	VERB
fnp-6282	72	5	using	use	VERB
fnp-6282	72	6	dab	dab	PROPN
fnp-6282	72	7	as	as	ADP
fnp-6282	72	8	the	the	DET
fnp-6282	72	9	chromogen	chromogen	NOUN
fnp-6282	72	10	,	,	PUNCT
fnp-6282	72	11	counterstained	counterstaine	VERB
fnp-6282	72	12	with	with	ADP
fnp-6282	72	13	hematoxylin	hematoxylin	NOUN
fnp-6282	72	14	,	,	PUNCT
fnp-6282	72	15	mounted	mount	VERB
fnp-6282	72	16	and	and	CCONJ
fnp-6282	72	17	coverslipped	coverslippe	VERB
fnp-6282	72	18	.	.	PUNCT
fnp-6282	73	1	results	result	VERB
fnp-6282	73	2	prps	prps	PROPN
fnp-6282	73	3	ncs	ncs	PROPN
fnp-6282	73	4	are	be	AUX
fnp-6282	73	5	present	present	ADJ
fnp-6282	73	6	in	in	ADP
fnp-6282	73	7	the	the	DET
fnp-6282	73	8	brain	brain	NOUN
fnp-6282	73	9	figure	figure	NOUN
fnp-6282	73	10	 	 	SPACE
fnp-6282	73	11	1	1	NUM
fnp-6282	73	12	shows	show	VERB
fnp-6282	73	13	prps	prps	PROPN
fnp-6282	73	14	-	-	PUNCT
fnp-6282	73	15	immunoreactive	immunoreactive	ADJ
fnp-6282	73	16	ncs	ncs	NOUN
fnp-6282	73	17	in	in	ADP
fnp-6282	73	18	double	double	ADJ
fnp-6282	73	19	immunostained	immunostaine	VERB
fnp-6282	73	20	sections	section	NOUN
fnp-6282	73	21	of	of	ADP
fnp-6282	73	22	the	the	DET
fnp-6282	73	23	punches	punch	NOUN
fnp-6282	73	24	of	of	ADP
fnp-6282	73	25	temporal	temporal	ADJ
fnp-6282	73	26	cortex	cortex	NOUN
fnp-6282	73	27	in	in	ADP
fnp-6282	73	28	the	the	DET
fnp-6282	73	29	depth	depth	NOUN
fnp-6282	73	30	of	of	ADP
fnp-6282	73	31	the	the	DET
fnp-6282	73	32	collateral	collateral	ADJ
fnp-6282	73	33	sulcus	sulcus	NOUN
fnp-6282	73	34	.	.	PUNCT
fnp-6282	74	1	in	in	ADP
fnp-6282	74	2	both	both	PRON
fnp-6282	74	3	control	control	NOUN
fnp-6282	74	4	and	and	CCONJ
fnp-6282	74	5	disease	disease	NOUN
fnp-6282	74	6	cases	case	NOUN
fnp-6282	74	7	,	,	PUNCT
fnp-6282	74	8	these	these	PRON
fnp-6282	74	9	were	be	AUX
fnp-6282	74	10	most	most	ADV
fnp-6282	74	11	prevalent	prevalent	ADJ
fnp-6282	74	12	in	in	ADP
fnp-6282	74	13	layers	layers	PROPN
fnp-6282	74	14	ii	ii	PROPN
fnp-6282	74	15	,	,	PUNCT
fnp-6282	74	16	v	v	NOUN
fnp-6282	74	17	,	,	PUNCT
fnp-6282	74	18	and	and	CCONJ
fnp-6282	74	19	vi	vi	NOUN
fnp-6282	74	20	.	.	PUNCT
fnp-6282	75	1	they	they	PRON
fnp-6282	75	2	were	be	AUX
fnp-6282	75	3	present	present	ADJ
fnp-6282	75	4	in	in	ADP
fnp-6282	75	5	both	both	DET
fnp-6282	75	6	pyramidal	pyramidal	ADJ
fnp-6282	75	7	neurons	neuron	NOUN
fnp-6282	75	8	as	as	ADV
fnp-6282	75	9	well	well	ADV
fnp-6282	75	10	as	as	ADP
fnp-6282	75	11	non	non	ADJ
fnp-6282	75	12	-	-	ADJ
fnp-6282	75	13	pyramidal	pyramidal	ADJ
fnp-6282	75	14	neurons	neuron	NOUN
fnp-6282	75	15	of	of	ADP
fnp-6282	75	16	various	various	ADJ
fnp-6282	75	17	morphologies	morphology	NOUN
fnp-6282	75	18	.	.	PUNCT
fnp-6282	76	1	they	they	PRON
fnp-6282	76	2	showed	show	VERB
fnp-6282	76	3	a	a	DET
fnp-6282	76	4	variety	variety	NOUN
fnp-6282	76	5	of	of	ADP
fnp-6282	76	6	shapes	shape	NOUN
fnp-6282	76	7	,	,	PUNCT
fnp-6282	76	8	ranging	range	VERB
fnp-6282	76	9	from	from	ADP
fnp-6282	76	10	rodor	rodor	ADJ
fnp-6282	76	11	thread	thread	NOUN
fnp-6282	76	12	-	-	PUNCT
fnp-6282	76	13	like	like	ADJ
fnp-6282	76	14	linear	linear	NOUN
fnp-6282	76	15	or	or	CCONJ
fnp-6282	76	16	curvilinear	curvilinear	ADJ
fnp-6282	76	17	structures	structure	NOUN
fnp-6282	76	18	(	(	PUNCT
fnp-6282	76	19	fig	fig	NOUN
fnp-6282	76	20	.	.	PUNCT
fnp-6282	76	21	 	 	SPACE
fnp-6282	76	22	1a	1a	NOUN
fnp-6282	76	23	)	)	PUNCT
fnp-6282	76	24	to	to	ADP
fnp-6282	76	25	dot	dot	NOUN
fnp-6282	76	26	-	-	PUNCT
fnp-6282	76	27	shaped	shape	VERB
fnp-6282	76	28	structures	structure	NOUN
fnp-6282	76	29	or	or	CCONJ
fnp-6282	76	30	large	large	ADJ
fnp-6282	76	31	,	,	PUNCT
fnp-6282	76	32	irregular	irregular	ADJ
fnp-6282	76	33	"	"	PUNCT
fnp-6282	76	34	crystalloid	crystalloid	ADJ
fnp-6282	76	35	"	"	PUNCT
fnp-6282	76	36	sheets	sheet	NOUN
fnp-6282	76	37	(	(	PUNCT
fnp-6282	76	38	fig	fig	NOUN
fnp-6282	76	39	.	.	PUNCT
fnp-6282	76	40	 	 	SPACE
fnp-6282	76	41	1b	1b	NUM
fnp-6282	76	42	)	)	PUNCT
fnp-6282	76	43	.	.	PUNCT
fnp-6282	77	1	some	some	PRON
fnp-6282	77	2	of	of	ADP
fnp-6282	77	3	the	the	DET
fnp-6282	77	4	latter	latter	NOUN
fnp-6282	77	5	showed	show	VERB
fnp-6282	77	6	a	a	DET
fnp-6282	77	7	rhomboid	rhomboid	NOUN
fnp-6282	77	8	shape	shape	NOUN
fnp-6282	77	9	as	as	SCONJ
fnp-6282	77	10	reported	report	VERB
fnp-6282	77	11	for	for	ADP
fnp-6282	77	12	impdh	impdh	NOUN
fnp-6282	77	13	ncs	ncs	NOUN
fnp-6282	77	14	in	in	ADP
fnp-6282	77	15	substantia	substantia	PROPN
fnp-6282	77	16	nigra	nigra	NOUN
fnp-6282	77	17	neurons	neuron	NOUN
fnp-6282	77	18	[	[	X
fnp-6282	77	19	64	64	NUM
fnp-6282	77	20	]	]	PUNCT
fnp-6282	77	21	.	.	PUNCT
fnp-6282	78	1	in	in	ADP
fnp-6282	78	2	a	a	DET
fnp-6282	78	3	proportion	proportion	NOUN
fnp-6282	78	4	of	of	ADP
fnp-6282	78	5	neurons	neuron	NOUN
fnp-6282	78	6	,	,	PUNCT
fnp-6282	78	7	the	the	DET
fnp-6282	78	8	nucleolus	nucleolus	NOUN
fnp-6282	78	9	showed	show	VERB
fnp-6282	78	10	intense	intense	ADJ
fnp-6282	78	11	staining	staining	NOUN
fnp-6282	78	12	for	for	ADP
fnp-6282	78	13	prps	prps	PROPN
fnp-6282	78	14	(	(	PUNCT
fnp-6282	78	15	fig	fig	NOUN
fnp-6282	78	16	.	.	PUNCT
fnp-6282	78	17	 	 	SPACE
fnp-6282	78	18	1c	1c	NOUN
fnp-6282	78	19	)	)	PUNCT
fnp-6282	78	20	.	.	PUNCT
fnp-6282	79	1	this	this	PRON
fnp-6282	79	2	was	be	AUX
fnp-6282	79	3	seen	see	VERB
fnp-6282	79	4	both	both	PRON
fnp-6282	79	5	in	in	ADP
fnp-6282	79	6	neurons	neuron	NOUN
fnp-6282	79	7	with	with	ADP
fnp-6282	79	8	and	and	CCONJ
fnp-6282	79	9	without	without	ADP
fnp-6282	79	10	ncs	nc	NOUN
fnp-6282	79	11	.	.	PUNCT
fnp-6282	80	1	in	in	ADP
fnp-6282	80	2	addition	addition	NOUN
fnp-6282	80	3	to	to	ADP
fnp-6282	80	4	ncs	ncs	NOUN
fnp-6282	80	5	,	,	PUNCT
fnp-6282	80	6	most	most	ADJ
fnp-6282	80	7	neurons	neuron	NOUN
fnp-6282	80	8	showed	show	VERB
fnp-6282	80	9	innumerable	innumerable	ADJ
fnp-6282	80	10	micron	micron	NOUN
fnp-6282	80	11	-	-	PUNCT
fnp-6282	80	12	sized	sized	ADJ
fnp-6282	80	13	curvilinear	curvilinear	ADJ
fnp-6282	80	14	cytoplasmic	cytoplasmic	ADJ
fnp-6282	80	15	threads	thread	NOUN
fnp-6282	80	16	filling	fill	VERB
fnp-6282	80	17	the	the	DET
fnp-6282	80	18	perikaryal	perikaryal	NOUN
fnp-6282	80	19	and	and	CCONJ
fnp-6282	80	20	neuritic	neuritic	ADJ
fnp-6282	80	21	cytoplasm	cytoplasm	NOUN
fnp-6282	80	22	and	and	CCONJ
fnp-6282	80	23	contributing	contribute	VERB
fnp-6282	80	24	to	to	ADP
fnp-6282	80	25	a	a	DET
fnp-6282	80	26	punctate	punctate	NOUN
fnp-6282	80	27	staining	stain	VERB
fnp-6282	80	28	pattern	pattern	NOUN
fnp-6282	80	29	of	of	ADP
fnp-6282	80	30	the	the	DET
fnp-6282	80	31	background	background	NOUN
fnp-6282	80	32	neuropil	neuropil	PROPN
fnp-6282	80	33	(	(	PUNCT
fnp-6282	80	34	fig	fig	NOUN
fnp-6282	80	35	.	.	PUNCT
fnp-6282	80	36	 	 	SPACE
fnp-6282	80	37	1d	1d	NUM
fnp-6282	80	38	)	)	PUNCT
fnp-6282	80	39	.	.	PUNCT
fnp-6282	81	1	fig	fig	NOUN
fnp-6282	81	2	.	.	PUNCT
fnp-6282	81	3	 	 	SPACE
fnp-6282	82	1	1	1	NUM
fnp-6282	82	2	dual	dual	ADJ
fnp-6282	82	3	-	-	PUNCT
fnp-6282	82	4	labelling	labelling	NOUN
fnp-6282	82	5	immunofluorescence	immunofluorescence	NOUN
fnp-6282	82	6	for	for	ADP
fnp-6282	82	7	prps	prps	PROPN
fnp-6282	82	8	(	(	PUNCT
fnp-6282	82	9	green	green	PROPN
fnp-6282	82	10	)	)	PUNCT
fnp-6282	82	11	and	and	CCONJ
fnp-6282	82	12	map2	map2	PROPN
fnp-6282	82	13	(	(	PUNCT
fnp-6282	82	14	red	red	PROPN
fnp-6282	82	15	)	)	PUNCT
fnp-6282	82	16	in	in	ADP
fnp-6282	82	17	a	a	DET
fnp-6282	82	18	core	core	NOUN
fnp-6282	82	19	of	of	ADP
fnp-6282	82	20	temporal	temporal	ADJ
fnp-6282	82	21	cortex	cortex	NOUN
fnp-6282	82	22	from	from	ADP
fnp-6282	82	23	a	a	DET
fnp-6282	82	24	control	control	NOUN
fnp-6282	82	25	subject	subject	NOUN
fnp-6282	82	26	.	.	PUNCT
fnp-6282	83	1	a	a	DET
fnp-6282	83	2	,	,	PUNCT
fnp-6282	83	3	b	b	NOUN
fnp-6282	83	4	)	)	PUNCT
fnp-6282	83	5	neurons	neuron	NOUN
fnp-6282	83	6	containing	contain	VERB
fnp-6282	83	7	linear	linear	NOUN
fnp-6282	83	8	or	or	CCONJ
fnp-6282	83	9	curvilinear	curvilinear	NOUN
fnp-6282	83	10	(	(	PUNCT
fnp-6282	83	11	a	a	NOUN
fnp-6282	83	12	)	)	PUNCT
fnp-6282	83	13	or	or	CCONJ
fnp-6282	83	14	irregular	irregular	ADJ
fnp-6282	83	15	sheet	sheet	NOUN
fnp-6282	83	16	-	-	PUNCT
fnp-6282	83	17	like	like	ADJ
fnp-6282	83	18	(	(	PUNCT
fnp-6282	83	19	b	b	NOUN
fnp-6282	83	20	)	)	PUNCT
fnp-6282	83	21	ncs	ncs	NOUN
fnp-6282	83	22	.	.	PUNCT
fnp-6282	84	1	c	c	X
fnp-6282	84	2	)	)	PUNCT
fnp-6282	84	3	prps	prps	PROPN
fnp-6282	84	4	staining	stain	VERB
fnp-6282	84	5	of	of	ADP
fnp-6282	84	6	the	the	DET
fnp-6282	84	7	nucleoli	nucleoli	NOUN
fnp-6282	84	8	in	in	ADP
fnp-6282	84	9	two	two	NUM
fnp-6282	84	10	neurons	neuron	NOUN
fnp-6282	84	11	.	.	PUNCT
fnp-6282	85	1	in	in	ADP
fnp-6282	85	2	both	both	DET
fnp-6282	85	3	cases	case	NOUN
fnp-6282	85	4	,	,	PUNCT
fnp-6282	85	5	there	there	PRON
fnp-6282	85	6	are	be	VERB
fnp-6282	85	7	small	small	ADJ
fnp-6282	85	8	ncs	nc	NOUN
fnp-6282	85	9	juxtaposed	juxtapose	VERB
fnp-6282	85	10	to	to	ADP
fnp-6282	85	11	the	the	DET
fnp-6282	85	12	nucleoli	nucleolus	NOUN
fnp-6282	85	13	(	(	PUNCT
fnp-6282	85	14	arrowheads	arrowhead	NOUN
fnp-6282	85	15	)	)	PUNCT
fnp-6282	85	16	.	.	PUNCT
fnp-6282	86	1	d	d	X
fnp-6282	86	2	)	)	PUNCT
fnp-6282	86	3	higher	high	ADJ
fnp-6282	86	4	magnification	magnification	NOUN
fnp-6282	86	5	of	of	ADP
fnp-6282	86	6	the	the	DET
fnp-6282	86	7	proximal	proximal	ADJ
fnp-6282	86	8	apical	apical	ADJ
fnp-6282	86	9	dendrite	dendrite	NOUN
fnp-6282	86	10	of	of	ADP
fnp-6282	86	11	the	the	DET
fnp-6282	86	12	pyramidal	pyramidal	ADJ
fnp-6282	86	13	neuron	neuron	NOUN
fnp-6282	86	14	in	in	ADP
fnp-6282	86	15	b	b	NOUN
fnp-6282	86	16	showing	show	VERB
fnp-6282	86	17	small	small	ADJ
fnp-6282	86	18	curvilinear	curvilinear	NOUN
fnp-6282	86	19	cytoplasmic	cytoplasmic	ADJ
fnp-6282	86	20	prps	prps	PROPN
fnp-6282	86	21	filaments	filament	NOUN
fnp-6282	86	22	within	within	ADP
fnp-6282	86	23	the	the	DET
fnp-6282	86	24	dendrite	dendrite	NOUN
fnp-6282	86	25	and	and	CCONJ
fnp-6282	86	26	dot	dot	NOUN
fnp-6282	86	27	-	-	PUNCT
fnp-6282	86	28	like	like	ADJ
fnp-6282	86	29	structures	structure	NOUN
fnp-6282	86	30	throughout	throughout	ADP
fnp-6282	86	31	the	the	DET
fnp-6282	86	32	surrounding	surround	VERB
fnp-6282	86	33	neuropil	neuropil	NOUN
fnp-6282	86	34	.	.	PUNCT
fnp-6282	87	1	scale	scale	NOUN
fnp-6282	87	2	bars	bar	NOUN
fnp-6282	87	3	 	 	SPACE
fnp-6282	87	4	=	=	NOUN
fnp-6282	87	5	 	 	SPACE
fnp-6282	87	6	20	20	NUM
fnp-6282	87	7	microns	micron	NOUN
fnp-6282	87	8	.	.	PUNCT
fnp-6282	88	1	prps	prps	PROPN
fnp-6282	88	2	ncs	ncs	PROPN
fnp-6282	88	3	are	be	AUX
fnp-6282	88	4	reduced	reduce	VERB
fnp-6282	88	5	in	in	ADP
fnp-6282	88	6	the	the	DET
fnp-6282	88	7	ad	ad	NOUN
fnp-6282	88	8	temporal	temporal	ADJ
fnp-6282	88	9	cortex	cortex	NOUN
fnp-6282	88	10	the	the	DET
fnp-6282	88	11	box	box	PROPN
fnp-6282	88	12	plot	plot	NOUN
fnp-6282	88	13	in	in	ADP
fnp-6282	88	14	fig	fig	NOUN
fnp-6282	88	15	.	.	PUNCT
fnp-6282	88	16	 	 	SPACE
fnp-6282	89	1	2	2	NUM
fnp-6282	89	2	shows	show	VERB
fnp-6282	89	3	the	the	DET
fnp-6282	89	4	results	result	NOUN
fnp-6282	89	5	of	of	ADP
fnp-6282	89	6	our	our	PRON
fnp-6282	89	7	quantitative	quantitative	ADJ
fnp-6282	89	8	analysis	analysis	NOUN
fnp-6282	89	9	.	.	PUNCT
fnp-6282	90	1	there	there	PRON
fnp-6282	90	2	was	be	VERB
fnp-6282	90	3	significant	significant	ADJ
fnp-6282	90	4	inter	inter	ADJ
fnp-6282	90	5	-	-	ADJ
fnp-6282	90	6	individual	individual	ADJ
fnp-6282	90	7	variability	variability	NOUN
fnp-6282	90	8	in	in	ADP
fnp-6282	90	9	the	the	DET
fnp-6282	90	10	density	density	NOUN
fnp-6282	90	11	of	of	ADP
fnp-6282	90	12	ncs	ncs	PROPN
fnp-6282	90	13	.	.	PUNCT
fnp-6282	91	1	quantitative	quantitative	ADJ
fnp-6282	91	2	analysis	analysis	NOUN
fnp-6282	91	3	confirmed	confirm	VERB
fnp-6282	91	4	a	a	DET
fnp-6282	91	5	significant	significant	ADJ
fnp-6282	91	6	depletion	depletion	NOUN
fnp-6282	91	7	of	of	ADP
fnp-6282	91	8	ncs	ncs	NOUN
fnp-6282	91	9	in	in	ADP
fnp-6282	91	10	participants	participant	NOUN
fnp-6282	91	11	with	with	ADP
fnp-6282	91	12	ad	ad	NOUN
fnp-6282	91	13	relative	relative	ADJ
fnp-6282	91	14	to	to	ADP
fnp-6282	91	15	cognitively	cognitively	ADV
fnp-6282	91	16	intact	intact	ADJ
fnp-6282	91	17	age	age	NOUN
fnp-6282	91	18	-	-	PUNCT
fnp-6282	91	19	matched	match	VERB
fnp-6282	91	20	controls	control	NOUN
fnp-6282	91	21	,	,	PUNCT
fnp-6282	91	22	including	include	VERB
fnp-6282	91	23	those	those	PRON
fnp-6282	91	24	with	with	ADP
fnp-6282	91	25	heavy	heavy	ADJ
fnp-6282	91	26	beta	beta	NOUN
fnp-6282	91	27	-	-	PUNCT
fnp-6282	91	28	amyloid	amyloid	NOUN
fnp-6282	91	29	deposition	deposition	NOUN
fnp-6282	91	30	,	,	PUNCT
fnp-6282	91	31	as	as	ADV
fnp-6282	91	32	well	well	ADV
fnp-6282	91	33	as	as	ADP
fnp-6282	91	34	those	those	PRON
fnp-6282	91	35	with	with	ADP
fnp-6282	91	36	lbd	lbd	PROPN
fnp-6282	91	37	and	and	CCONJ
fnp-6282	91	38	4r	4r	NUM
fnp-6282	91	39	tauopathies	tauopathie	NOUN
fnp-6282	91	40	(	(	PUNCT
fnp-6282	91	41	psp	psp	NOUN
fnp-6282	91	42	/	/	SYM
fnp-6282	91	43	cbd	cbd	NOUN
fnp-6282	91	44	)	)	PUNCT
fnp-6282	91	45	(	(	PUNCT
fnp-6282	91	46	anova	anova	PROPN
fnp-6282	91	47	p	p	X
fnp-6282	91	48	 	 	SPACE
fnp-6282	91	49	<	<	X
fnp-6282	91	50	 	 	SPACE
fnp-6282	91	51	0.02	0.02	NUM
fnp-6282	91	52	,	,	PUNCT
fnp-6282	91	53	see	see	VERB
fnp-6282	91	54	figure	figure	NOUN
fnp-6282	91	55	 	 	SPACE
fnp-6282	91	56	2	2	NUM
fnp-6282	91	57	for	for	ADP
fnp-6282	91	58	pairwise	pairwise	NOUN
fnp-6282	91	59	comparisons	comparison	NOUN
fnp-6282	91	60	)	)	PUNCT
fnp-6282	91	61	.	.	PUNCT
fnp-6282	92	1	patients	patient	NOUN
fnp-6282	92	2	with	with	ADP
fnp-6282	92	3	lbd	lbd	PROPN
fnp-6282	92	4	and	and	CCONJ
fnp-6282	92	5	4	4	NUM
fnp-6282	92	6	-	-	PUNCT
fnp-6282	92	7	repeat	repeat	NOUN
fnp-6282	92	8	tauopathies	tauopathie	NOUN
fnp-6282	92	9	did	do	AUX
fnp-6282	92	10	not	not	PART
fnp-6282	92	11	differ	differ	VERB
fnp-6282	92	12	from	from	ADP
fnp-6282	92	13	controls	control	NOUN
fnp-6282	92	14	(	(	PUNCT
fnp-6282	92	15	p	p	NOUN
fnp-6282	92	16	 	 	SPACE
fnp-6282	92	17	=	=	NOUN
fnp-6282	92	18	 	 	SPACE
fnp-6282	92	19	0.2749	0.2749	NUM
fnp-6282	92	20	and	and	CCONJ
fnp-6282	92	21	0.9897	0.9897	NUM
fnp-6282	92	22	,	,	PUNCT
fnp-6282	92	23	respectively	respectively	ADV
fnp-6282	92	24	)	)	PUNCT
fnp-6282	92	25	.	.	PUNCT
fnp-6282	93	1	the	the	DET
fnp-6282	93	2	presence	presence	NOUN
fnp-6282	93	3	of	of	ADP
fnp-6282	93	4	heavy	heavy	ADJ
fnp-6282	93	5	beta	beta	NOUN
fnp-6282	93	6	-	-	PUNCT
fnp-6282	93	7	amyloid	amyloid	NOUN
fnp-6282	93	8	deposition	deposition	NOUN
fnp-6282	93	9	in	in	ADP
fnp-6282	93	10	cognitively	cognitively	ADV
fnp-6282	93	11	normal	normal	ADJ
fnp-6282	93	12	individuals	individual	NOUN
fnp-6282	93	13	did	do	AUX
fnp-6282	93	14	not	not	PART
fnp-6282	93	15	impact	impact	VERB
fnp-6282	93	16	nc	nc	PROPN
fnp-6282	93	17	density	density	PROPN
fnp-6282	93	18	relative	relative	ADJ
fnp-6282	93	19	to	to	ADP
fnp-6282	93	20	the	the	DET
fnp-6282	93	21	control	control	NOUN
fnp-6282	93	22	population	population	NOUN
fnp-6282	93	23	(	(	PUNCT
fnp-6282	93	24	p	p	X
fnp-6282	93	25	 	 	SPACE
fnp-6282	93	26	=	=	NOUN
fnp-6282	93	27	 	 	SPACE
fnp-6282	93	28	0.9322	0.9322	NUM
fnp-6282	93	29	)	)	PUNCT
fnp-6282	93	30	.	.	PUNCT
fnp-6282	94	1	there	there	PRON
fnp-6282	94	2	were	be	VERB
fnp-6282	94	3	no	no	DET
fnp-6282	94	4	discernible	discernible	ADJ
fnp-6282	94	5	qualitative	qualitative	ADJ
fnp-6282	94	6	differences	difference	NOUN
fnp-6282	94	7	in	in	ADP
fnp-6282	94	8	the	the	DET
fnp-6282	94	9	appearance	appearance	NOUN
fnp-6282	94	10	or	or	CCONJ
fnp-6282	94	11	morphology	morphology	NOUN
fnp-6282	94	12	of	of	ADP
fnp-6282	94	13	ncs	ncs	NOUN
fnp-6282	94	14	between	between	ADP
fnp-6282	94	15	ad	ad	NOUN
fnp-6282	94	16	participants	participant	NOUN
fnp-6282	94	17	,	,	PUNCT
fnp-6282	94	18	any	any	DET
fnp-6282	94	19	other	other	ADJ
fnp-6282	94	20	disease	disease	NOUN
fnp-6282	94	21	groups	group	NOUN
fnp-6282	94	22	,	,	PUNCT
fnp-6282	94	23	and	and	CCONJ
fnp-6282	94	24	controls	control	NOUN
fnp-6282	94	25	.	.	PUNCT
fnp-6282	95	1	fig	fig	NOUN
fnp-6282	95	2	.	.	PUNCT
fnp-6282	95	3	 	 	SPACE
fnp-6282	96	1	2	2	NUM
fnp-6282	96	2	box	box	NOUN
fnp-6282	96	3	plot	plot	NOUN
fnp-6282	96	4	comparing	compare	VERB
fnp-6282	96	5	frequency	frequency	NOUN
fnp-6282	96	6	of	of	ADP
fnp-6282	96	7	ncs	ncs	NOUN
fnp-6282	96	8	in	in	ADP
fnp-6282	96	9	cores	core	NOUN
fnp-6282	96	10	of	of	ADP
fnp-6282	96	11	temporal	temporal	ADJ
fnp-6282	96	12	cortex	cortex	NOUN
fnp-6282	96	13	from	from	ADP
fnp-6282	96	14	our	our	PRON
fnp-6282	96	15	cohort	cohort	NOUN
fnp-6282	96	16	.	.	PUNCT
fnp-6282	97	1	anova	anova	PROPN
fnp-6282	97	2	for	for	ADP
fnp-6282	97	3	the	the	DET
fnp-6282	97	4	entire	entire	ADJ
fnp-6282	97	5	group	group	NOUN
fnp-6282	97	6	p	p	X
fnp-6282	97	7	 	 	SPACE
fnp-6282	97	8	<	<	X
fnp-6282	97	9	 	 	SPACE
fnp-6282	97	10	0.02	0.02	NUM
fnp-6282	97	11	.	.	PUNCT
fnp-6282	98	1	pairwise	pairwise	NOUN
fnp-6282	98	2	comparisons	comparison	NOUN
fnp-6282	98	3	conducted	conduct	VERB
fnp-6282	98	4	using	use	VERB
fnp-6282	98	5	bonferroni	bonferroni	NOUN
fnp-6282	98	6	’s	’s	PART
fnp-6282	98	7	multiple	multiple	ADJ
fnp-6282	98	8	comparisons	comparison	NOUN
fnp-6282	98	9	test	test	NOUN
fnp-6282	98	10	.	.	PUNCT
fnp-6282	99	1	comparisons	comparison	NOUN
fnp-6282	99	2	reaching	reach	VERB
fnp-6282	99	3	the	the	DET
fnp-6282	99	4	significance	significance	NOUN
fnp-6282	99	5	level	level	NOUN
fnp-6282	99	6	(	(	PUNCT
fnp-6282	99	7	p	p	X
fnp-6282	99	8	 	 	SPACE
fnp-6282	99	9	<	<	X
fnp-6282	99	10	 	 	SPACE
fnp-6282	99	11	0.05	0.05	NUM
fnp-6282	99	12	)	)	PUNCT
fnp-6282	99	13	are	be	AUX
fnp-6282	99	14	shown	show	VERB
fnp-6282	99	15	on	on	ADP
fnp-6282	99	16	the	the	DET
fnp-6282	99	17	graph	graph	NOUN
fnp-6282	99	18	.	.	PUNCT
fnp-6282	100	1	all	all	DET
fnp-6282	100	2	other	other	ADJ
fnp-6282	100	3	comparisons	comparison	NOUN
fnp-6282	100	4	did	do	AUX
fnp-6282	100	5	not	not	PART
fnp-6282	100	6	reach	reach	VERB
fnp-6282	100	7	this	this	DET
fnp-6282	100	8	level	level	NOUN
fnp-6282	100	9	.	.	PUNCT
fnp-6282	101	1	ad	ad	NOUN
fnp-6282	101	2	;	;	PUNCT
fnp-6282	101	3	alzheimer	alzheimer	PROPN
fnp-6282	101	4	's	's	PART
fnp-6282	101	5	disease	disease	NOUN
fnp-6282	101	6	,	,	PUNCT
fnp-6282	101	7	amyloid	amyloid	NOUN
fnp-6282	101	8	;	;	PUNCT
fnp-6282	101	9	cognitively	cognitively	ADV
fnp-6282	101	10	normal	normal	ADJ
fnp-6282	101	11	subjects	subject	NOUN
fnp-6282	101	12	with	with	ADP
fnp-6282	101	13	high	high	ADJ
fnp-6282	101	14	density	density	NOUN
fnp-6282	101	15	of	of	ADP
fnp-6282	101	16	amyloid	amyloid	NOUN
fnp-6282	101	17	plaques	plaque	NOUN
fnp-6282	101	18	,	,	PUNCT
fnp-6282	101	19	lbd	lbd	PROPN
fnp-6282	101	20	;	;	PUNCT
fnp-6282	101	21	lewy	lewy	PROPN
fnp-6282	101	22	body	body	NOUN
fnp-6282	101	23	disease	disease	NOUN
fnp-6282	101	24	,	,	PUNCT
fnp-6282	101	25	psp	psp	NOUN
fnp-6282	101	26	/	/	SYM
fnp-6282	101	27	cbd	cbd	PROPN
fnp-6282	101	28	;	;	PUNCT
fnp-6282	101	29	progressive	progressive	ADJ
fnp-6282	101	30	supranuclear	supranuclear	ADJ
fnp-6282	101	31	palsy	palsy	ADJ
fnp-6282	101	32	/	/	SYM
fnp-6282	101	33	corticobasal	corticobasal	NOUN
fnp-6282	101	34	degeneration	degeneration	NOUN
fnp-6282	101	35	.	.	PUNCT
fnp-6282	102	1	*	*	PUNCT
fnp-6282	103	1	*	*	PUNCT
fnp-6282	103	2	*	*	PUNCT
fnp-6282	103	3	*	*	PUNCT
fnp-6282	103	4	p	p	X
fnp-6282	103	5	 	 	SPACE
fnp-6282	103	6	<	<	X
fnp-6282	103	7	 	 	SPACE
fnp-6282	103	8	0.0001	0.0001	NUM
fnp-6282	103	9	,	,	PUNCT
fnp-6282	103	10	*	*	PUNCT
fnp-6282	103	11	p	p	X
fnp-6282	103	12	 	 	SPACE
fnp-6282	103	13	<	<	X
fnp-6282	103	14	 	 	SPACE
fnp-6282	103	15	0.05	0.05	NUM
fnp-6282	103	16	.	.	PUNCT
fnp-6282	103	17	,	,	PUNCT
fnp-6282	103	18	*	*	PUNCT
fnp-6282	104	1	*	*	PUNCT
fnp-6282	104	2	p	p	X
fnp-6282	104	3	 	 	SPACE
fnp-6282	104	4	<	<	NOUN
fnp-6282	104	5	 	 	SPACE
fnp-6282	104	6	0.005	0.005	NUM
fnp-6282	104	7	.	.	PUNCT
fnp-6282	105	1	prps	prps	PROPN
fnp-6282	105	2	ncs	ncs	PROPN
fnp-6282	105	3	are	be	AUX
fnp-6282	105	4	more	more	ADV
fnp-6282	105	5	common	common	ADJ
fnp-6282	105	6	in	in	ADP
fnp-6282	105	7	nft	nft	PROPN
fnp-6282	105	8	-	-	PUNCT
fnp-6282	105	9	bearing	bear	VERB
fnp-6282	105	10	neurons	neuron	NOUN
fnp-6282	105	11	we	we	PRON
fnp-6282	105	12	explored	explore	VERB
fnp-6282	105	13	a	a	DET
fnp-6282	105	14	possible	possible	ADJ
fnp-6282	105	15	relationship	relationship	NOUN
fnp-6282	105	16	between	between	ADP
fnp-6282	105	17	ncs	nc	NOUN
fnp-6282	105	18	and	and	CCONJ
fnp-6282	105	19	neurofibrillary	neurofibrillary	ADJ
fnp-6282	105	20	tangles	tangle	NOUN
fnp-6282	105	21	(	(	PUNCT
fnp-6282	105	22	nfts	nft	NOUN
fnp-6282	105	23	)	)	PUNCT
fnp-6282	105	24	using	use	VERB
fnp-6282	105	25	double	double	ADJ
fnp-6282	105	26	immunofluorescence	immunofluorescence	NOUN
fnp-6282	105	27	staining	staining	NOUN
fnp-6282	105	28	of	of	ADP
fnp-6282	105	29	the	the	DET
fnp-6282	105	30	tmas	tma	NOUN
fnp-6282	105	31	for	for	ADP
fnp-6282	105	32	prps	prps	PROPN
fnp-6282	105	33	and	and	CCONJ
fnp-6282	105	34	ptau	ptau	PROPN
fnp-6282	105	35	(	(	PUNCT
fnp-6282	105	36	fig	fig	NOUN
fnp-6282	105	37	.	.	PUNCT
fnp-6282	105	38	 	 	SPACE
fnp-6282	106	1	3a	3a	NUM
fnp-6282	106	2	–	–	PUNCT
fnp-6282	106	3	c	c	NOUN
fnp-6282	106	4	)	)	PUNCT
fnp-6282	106	5	.	.	PUNCT
fnp-6282	107	1	a	a	DET
fnp-6282	107	2	significantly	significantly	ADV
fnp-6282	107	3	higher	high	ADJ
fnp-6282	107	4	proportion	proportion	NOUN
fnp-6282	107	5	of	of	ADP
fnp-6282	107	6	nft	nft	PROPN
fnp-6282	107	7	-	-	PUNCT
fnp-6282	107	8	bearing	bear	VERB
fnp-6282	107	9	neurons	neuron	NOUN
fnp-6282	107	10	contained	contain	VERB
fnp-6282	107	11	ncs	ncs	NOUN
fnp-6282	107	12	relative	relative	ADJ
fnp-6282	107	13	to	to	ADP
fnp-6282	107	14	nft	nft	PROPN
fnp-6282	107	15	-	-	PUNCT
fnp-6282	107	16	negative	negative	ADJ
fnp-6282	107	17	neurons	neuron	NOUN
fnp-6282	107	18	,	,	PUNCT
fnp-6282	107	19	suggesting	suggest	VERB
fnp-6282	107	20	an	an	DET
fnp-6282	107	21	association	association	NOUN
fnp-6282	107	22	between	between	ADP
fnp-6282	107	23	these	these	DET
fnp-6282	107	24	two	two	NUM
fnp-6282	107	25	proteinaceous	proteinaceous	ADJ
fnp-6282	107	26	bodies	body	NOUN
fnp-6282	107	27	.	.	PUNCT
fnp-6282	108	1	specifically	specifically	ADV
fnp-6282	108	2	,	,	PUNCT
fnp-6282	108	3	of	of	ADP
fnp-6282	108	4	64	64	NUM
fnp-6282	108	5	nft	nft	NOUN
fnp-6282	108	6	-	-	PUNCT
fnp-6282	108	7	containing	contain	VERB
fnp-6282	108	8	neurons	neuron	NOUN
fnp-6282	108	9	,	,	PUNCT
fnp-6282	108	10	9	9	NUM
fnp-6282	108	11	(	(	PUNCT
fnp-6282	108	12	14	14	NUM
fnp-6282	108	13	 	 	SPACE
fnp-6282	108	14	%	%	NOUN
fnp-6282	108	15	)	)	PUNCT
fnp-6282	108	16	contained	contain	VERB
fnp-6282	108	17	ncs	nc	NOUN
fnp-6282	108	18	.	.	PUNCT
fnp-6282	109	1	conversely	conversely	ADV
fnp-6282	109	2	,	,	PUNCT
fnp-6282	109	3	of	of	ADP
fnp-6282	109	4	4,977	4,977	NUM
fnp-6282	109	5	neurons	neuron	NOUN
fnp-6282	109	6	lacking	lack	VERB
fnp-6282	109	7	nfts	nft	NOUN
fnp-6282	109	8	,	,	PUNCT
fnp-6282	109	9	only	only	ADV
fnp-6282	109	10	145	145	NUM
fnp-6282	109	11	(	(	PUNCT
fnp-6282	109	12	2.9	2.9	NUM
fnp-6282	109	13	 	 	SPACE
fnp-6282	109	14	%	%	NOUN
fnp-6282	109	15	)	)	PUNCT
fnp-6282	109	16	contained	contain	VERB
fnp-6282	109	17	ncs	ncs	NOUN
fnp-6282	109	18	(	(	PUNCT
fnp-6282	109	19	fig	fig	NOUN
fnp-6282	109	20	.	.	PUNCT
fnp-6282	109	21	 	 	SPACE
fnp-6282	109	22	3d	3d	NOUN
fnp-6282	109	23	;	;	PUNCT
fnp-6282	109	24	chi	chi	NOUN
fnp-6282	109	25	-	-	PUNCT
fnp-6282	109	26	squared	square	VERB
fnp-6282	109	27	p	p	X
fnp-6282	109	28	 	 	SPACE
fnp-6282	109	29	<	<	X
fnp-6282	109	30	 	 	SPACE
fnp-6282	109	31	0.00001	0.00001	NUM
fnp-6282	109	32	)	)	PUNCT
fnp-6282	109	33	.	.	PUNCT
fnp-6282	110	1	fig	fig	NOUN
fnp-6282	110	2	.	.	PUNCT
fnp-6282	110	3	 	 	SPACE
fnp-6282	111	1	3	3	NUM
fnp-6282	111	2	a	a	DET
fnp-6282	111	3	–	–	PUNCT
fnp-6282	111	4	c	c	NOUN
fnp-6282	111	5	)	)	PUNCT
fnp-6282	111	6	dual	dual	ADJ
fnp-6282	111	7	labelling	labelling	NOUN
fnp-6282	111	8	immunofluorescence	immunofluorescence	NOUN
fnp-6282	111	9	for	for	ADP
fnp-6282	111	10	prps	prps	PROPN
fnp-6282	111	11	(	(	PUNCT
fnp-6282	111	12	green	green	NOUN
fnp-6282	111	13	)	)	PUNCT
fnp-6282	111	14	and	and	CCONJ
fnp-6282	111	15	ptau	ptau	ADV
fnp-6282	111	16	(	(	PUNCT
fnp-6282	111	17	red	red	ADJ
fnp-6282	111	18	)	)	PUNCT
fnp-6282	111	19	showing	show	VERB
fnp-6282	111	20	curvilinear	curvilinear	NOUN
fnp-6282	111	21	(	(	PUNCT
fnp-6282	111	22	a	a	X
fnp-6282	111	23	)	)	PUNCT
fnp-6282	111	24	,	,	PUNCT
fnp-6282	111	25	thread	thread	NOUN
fnp-6282	111	26	-	-	PUNCT
fnp-6282	111	27	like	like	ADJ
fnp-6282	111	28	(	(	PUNCT
fnp-6282	111	29	b	b	NOUN
fnp-6282	111	30	)	)	PUNCT
fnp-6282	111	31	and	and	CCONJ
fnp-6282	111	32	dot	dot	NOUN
fnp-6282	111	33	-	-	PUNCT
fnp-6282	111	34	like	like	ADJ
fnp-6282	111	35	(	(	PUNCT
fnp-6282	111	36	c	c	NOUN
fnp-6282	111	37	)	)	PUNCT
fnp-6282	111	38	ncs	ncs	NOUN
fnp-6282	111	39	in	in	ADP
fnp-6282	111	40	tangle	tangle	NOUN
fnp-6282	111	41	-	-	PUNCT
fnp-6282	111	42	bearing	bear	VERB
fnp-6282	111	43	neurons	neuron	NOUN
fnp-6282	111	44	.	.	PUNCT
fnp-6282	112	1	scale	scale	NOUN
fnp-6282	112	2	bars	bar	NOUN
fnp-6282	112	3	 	 	SPACE
fnp-6282	112	4	=	=	NOUN
fnp-6282	112	5	 	 	SPACE
fnp-6282	112	6	10	10	NUM
fnp-6282	112	7	microns	micron	NOUN
fnp-6282	112	8	.	.	PUNCT
fnp-6282	113	1	d	d	X
fnp-6282	113	2	)	)	PUNCT
fnp-6282	113	3	bar	bar	NOUN
fnp-6282	113	4	graph	graph	NOUN
fnp-6282	113	5	showing	show	VERB
fnp-6282	113	6	percentage	percentage	NOUN
fnp-6282	113	7	of	of	ADP
fnp-6282	113	8	nft	nft	PROPN
fnp-6282	113	9	-	-	PUNCT
fnp-6282	113	10	positive	positive	ADJ
fnp-6282	113	11	and	and	CCONJ
fnp-6282	113	12	nft	nft	PROPN
fnp-6282	113	13	-	-	PUNCT
fnp-6282	113	14	negative	negative	ADJ
fnp-6282	113	15	neurons	neuron	NOUN
fnp-6282	113	16	with	with	ADP
fnp-6282	113	17	(	(	PUNCT
fnp-6282	113	18	blue	blue	ADJ
fnp-6282	113	19	)	)	PUNCT
fnp-6282	113	20	and	and	CCONJ
fnp-6282	113	21	without	without	ADP
fnp-6282	113	22	(	(	PUNCT
fnp-6282	113	23	white	white	ADJ
fnp-6282	113	24	)	)	PUNCT
fnp-6282	113	25	ncs	nc	NOUN
fnp-6282	113	26	.	.	PUNCT
fnp-6282	114	1	chi	chi	ADJ
fnp-6282	114	2	-	-	PUNCT
fnp-6282	114	3	square	square	PROPN
fnp-6282	114	4	test	test	NOUN
fnp-6282	114	5	shows	show	VERB
fnp-6282	114	6	a	a	DET
fnp-6282	114	7	significantly	significantly	ADV
fnp-6282	114	8	higher	high	ADJ
fnp-6282	114	9	proportion	proportion	NOUN
fnp-6282	114	10	of	of	ADP
fnp-6282	114	11	nft	nft	PROPN
fnp-6282	114	12	bearing	bear	VERB
fnp-6282	114	13	neurons	neuron	NOUN
fnp-6282	114	14	contain	contain	VERB
fnp-6282	114	15	ncs	ncs	NOUN
fnp-6282	114	16	(	(	PUNCT
fnp-6282	114	17	p	p	X
fnp-6282	114	18	 	 	SPACE
fnp-6282	114	19	<	<	X
fnp-6282	114	20	 	 	SPACE
fnp-6282	114	21	0.00001	0.00001	NUM
fnp-6282	114	22	)	)	PUNCT
fnp-6282	114	23	.	.	PUNCT
fnp-6282	115	1	discussion	discussion	NOUN
fnp-6282	115	2	here	here	ADV
fnp-6282	115	3	we	we	PRON
fnp-6282	115	4	demonstrate	demonstrate	VERB
fnp-6282	115	5	a	a	DET
fnp-6282	115	6	significant	significant	ADJ
fnp-6282	115	7	depletion	depletion	NOUN
fnp-6282	115	8	of	of	ADP
fnp-6282	115	9	intranuclear	intranuclear	NOUN
fnp-6282	115	10	cytoophidia	cytoophidia	PROPN
fnp-6282	115	11	comprised	comprise	VERB
fnp-6282	115	12	of	of	ADP
fnp-6282	115	13	the	the	DET
fnp-6282	115	14	key	key	ADJ
fnp-6282	115	15	nucleotide	nucleotide	NOUN
fnp-6282	115	16	-	-	PUNCT
fnp-6282	115	17	synthesizing	synthesize	VERB
fnp-6282	115	18	enzyme	enzyme	NOUN
fnp-6282	115	19	prps	prps	NOUN
fnp-6282	115	20	from	from	ADP
fnp-6282	115	21	neurons	neuron	NOUN
fnp-6282	115	22	in	in	ADP
fnp-6282	115	23	the	the	DET
fnp-6282	115	24	ad	ad	NOUN
fnp-6282	115	25	cerebral	cerebral	ADJ
fnp-6282	115	26	cortex	cortex	NOUN
fnp-6282	115	27	,	,	PUNCT
fnp-6282	115	28	implicating	implicate	VERB
fnp-6282	115	29	these	these	DET
fnp-6282	115	30	enigmatic	enigmatic	ADJ
fnp-6282	115	31	structures	structure	NOUN
fnp-6282	115	32	in	in	ADP
fnp-6282	115	33	the	the	DET
fnp-6282	115	34	pathogenesis	pathogenesis	NOUN
fnp-6282	115	35	of	of	ADP
fnp-6282	115	36	ad	ad	NOUN
fnp-6282	115	37	.	.	PUNCT
fnp-6282	116	1	this	this	DET
fnp-6282	116	2	study	study	NOUN
fnp-6282	116	3	confirms	confirm	VERB
fnp-6282	116	4	and	and	CCONJ
fnp-6282	116	5	extends	extend	VERB
fnp-6282	116	6	the	the	DET
fnp-6282	116	7	results	result	NOUN
fnp-6282	116	8	of	of	ADP
fnp-6282	116	9	our	our	PRON
fnp-6282	116	10	previous	previous	ADJ
fnp-6282	116	11	study	study	NOUN
fnp-6282	116	12	demonstrating	demonstrate	VERB
fnp-6282	116	13	a	a	DET
fnp-6282	116	14	significant	significant	ADJ
fnp-6282	116	15	decrement	decrement	NOUN
fnp-6282	116	16	in	in	ADP
fnp-6282	116	17	the	the	DET
fnp-6282	116	18	density	density	NOUN
fnp-6282	116	19	of	of	ADP
fnp-6282	116	20	intranuclear	intranuclear	NOUN
fnp-6282	116	21	rodlets	rodlet	NOUN
fnp-6282	116	22	(	(	PUNCT
fnp-6282	116	23	inrs	inrs	NOUN
fnp-6282	116	24	)	)	PUNCT
fnp-6282	116	25	in	in	ADP
fnp-6282	116	26	the	the	DET
fnp-6282	116	27	temporal	temporal	ADJ
fnp-6282	116	28	cortex	cortex	NOUN
fnp-6282	116	29	of	of	ADP
fnp-6282	116	30	individuals	individual	NOUN
fnp-6282	116	31	with	with	ADP
fnp-6282	116	32	ad	ad	NOUN
fnp-6282	116	33	relative	relative	ADJ
fnp-6282	116	34	to	to	ADP
fnp-6282	116	35	cognitively	cognitively	ADV
fnp-6282	116	36	intact	intact	ADJ
fnp-6282	116	37	controls	control	NOUN
fnp-6282	116	38	and	and	CCONJ
fnp-6282	116	39	those	those	PRON
fnp-6282	116	40	with	with	ADP
fnp-6282	116	41	dementia	dementia	NOUN
fnp-6282	116	42	with	with	ADP
fnp-6282	116	43	lewy	lewy	ADJ
fnp-6282	116	44	bodies	body	NOUN
fnp-6282	116	45	[	[	X
fnp-6282	116	46	65	65	NUM
fnp-6282	116	47	]	]	PUNCT
fnp-6282	116	48	.	.	PUNCT
fnp-6282	117	1	these	these	DET
fnp-6282	117	2	structures	structure	NOUN
fnp-6282	117	3	correspond	correspond	VERB
fnp-6282	117	4	to	to	ADP
fnp-6282	117	5	the	the	DET
fnp-6282	117	6	"	"	PUNCT
fnp-6282	117	7	rodlets	rodlet	NOUN
fnp-6282	117	8	of	of	ADP
fnp-6282	117	9	roncoroni	roncoroni	NOUN
fnp-6282	117	10	"	"	PUNCT
fnp-6282	117	11	described	describe	VERB
fnp-6282	117	12	by	by	ADP
fnp-6282	117	13	the	the	DET
fnp-6282	117	14	classical	classical	ADJ
fnp-6282	117	15	microscopists	microscopist	NOUN
fnp-6282	117	16	(	(	PUNCT
fnp-6282	117	17	see	see	VERB
fnp-6282	117	18	[	[	X
fnp-6282	117	19	63	63	NUM
fnp-6282	117	20	]	]	NUM
fnp-6282	117	21	)	)	PUNCT
fnp-6282	117	22	.	.	PUNCT
fnp-6282	118	1	the	the	DET
fnp-6282	118	2	functional	functional	ADJ
fnp-6282	118	3	significance	significance	NOUN
fnp-6282	118	4	of	of	ADP
fnp-6282	118	5	these	these	DET
fnp-6282	118	6	structures	structure	NOUN
fnp-6282	118	7	has	have	AUX
fnp-6282	118	8	remained	remain	VERB
fnp-6282	118	9	enigmatic	enigmatic	ADJ
fnp-6282	118	10	.	.	PUNCT
fnp-6282	119	1	the	the	DET
fnp-6282	119	2	demonstration	demonstration	NOUN
fnp-6282	119	3	that	that	PRON
fnp-6282	119	4	they	they	PRON
fnp-6282	119	5	are	be	AUX
fnp-6282	119	6	immunoreactive	immunoreactive	ADJ
fnp-6282	119	7	for	for	ADP
fnp-6282	119	8	the	the	DET
fnp-6282	119	9	nucleotide	nucleotide	NOUN
fnp-6282	119	10	synthesizing	synthesize	VERB
fnp-6282	119	11	enzymes	enzyme	NOUN
fnp-6282	119	12	prps	prps	PROPN
fnp-6282	119	13	provides	provide	VERB
fnp-6282	119	14	a	a	DET
fnp-6282	119	15	novel	novel	ADJ
fnp-6282	119	16	functional	functional	ADJ
fnp-6282	119	17	context	context	NOUN
fnp-6282	119	18	;	;	PUNCT
fnp-6282	119	19	linking	link	VERB
fnp-6282	119	20	them	they	PRON
fnp-6282	119	21	to	to	ADP
fnp-6282	119	22	the	the	DET
fnp-6282	119	23	bundles	bundle	NOUN
fnp-6282	119	24	of	of	ADP
fnp-6282	119	25	metabolic	metabolic	NOUN
fnp-6282	119	26	enzyme	enzyme	NOUN
fnp-6282	119	27	filaments	filament	NOUN
fnp-6282	119	28	known	know	VERB
fnp-6282	119	29	as	as	ADP
fnp-6282	119	30	"	"	PUNCT
fnp-6282	119	31	cytoophidia	cytoophidia	PROPN
fnp-6282	119	32	"	"	PUNCT
fnp-6282	119	33	recently	recently	ADV
fnp-6282	119	34	described	describe	VERB
fnp-6282	119	35	by	by	ADP
fnp-6282	119	36	several	several	ADJ
fnp-6282	119	37	authors	author	NOUN
fnp-6282	119	38	(	(	PUNCT
fnp-6282	119	39	for	for	ADP
fnp-6282	119	40	a	a	DET
fnp-6282	119	41	review	review	NOUN
fnp-6282	119	42	,	,	PUNCT
fnp-6282	119	43	see	see	VERB
fnp-6282	119	44	[	[	X
fnp-6282	119	45	11	11	NUM
fnp-6282	119	46	]	]	NUM
fnp-6282	119	47	)	)	PUNCT
fnp-6282	119	48	.	.	PUNCT
fnp-6282	120	1	interestingly	interestingly	ADV
fnp-6282	120	2	,	,	PUNCT
fnp-6282	120	3	we	we	PRON
fnp-6282	120	4	have	have	AUX
fnp-6282	120	5	demonstrated	demonstrate	VERB
fnp-6282	120	6	that	that	SCONJ
fnp-6282	120	7	the	the	DET
fnp-6282	120	8	prps	prps	PROPN
fnp-6282	120	9	ncs	ncs	PROPN
fnp-6282	120	10	described	describe	VERB
fnp-6282	120	11	in	in	ADP
fnp-6282	120	12	this	this	DET
fnp-6282	120	13	study	study	NOUN
fnp-6282	120	14	are	be	AUX
fnp-6282	120	15	also	also	ADV
fnp-6282	120	16	immunoreactive	immunoreactive	ADJ
fnp-6282	120	17	for	for	ADP
fnp-6282	120	18	the	the	DET
fnp-6282	120	19	rate	rate	NOUN
fnp-6282	120	20	limiting	limit	VERB
fnp-6282	120	21	enzyme	enzyme	NOUN
fnp-6282	120	22	in	in	ADP
fnp-6282	120	23	purine	purine	NOUN
fnp-6282	120	24	nucleotide	nucleotide	NOUN
fnp-6282	120	25	synthesis	synthesis	NOUN
fnp-6282	120	26	,	,	PUNCT
fnp-6282	120	27	impdh	impdh	NOUN
fnp-6282	120	28	[	[	X
fnp-6282	120	29	63	63	NUM
fnp-6282	120	30	]	]	PUNCT
fnp-6282	120	31	.	.	PUNCT
fnp-6282	121	1	co	co	NOUN
fnp-6282	121	2	-	-	NOUN
fnp-6282	121	3	localization	localization	NOUN
fnp-6282	121	4	of	of	ADP
fnp-6282	121	5	metabolic	metabolic	NOUN
fnp-6282	121	6	enzymes	enzyme	NOUN
fnp-6282	121	7	in	in	ADP
fnp-6282	121	8	cytoophidia	cytoophidia	PROPN
fnp-6282	121	9	is	be	AUX
fnp-6282	121	10	common	common	ADJ
fnp-6282	121	11	.	.	PUNCT
fnp-6282	122	1	for	for	ADP
fnp-6282	122	2	example	example	NOUN
fnp-6282	122	3	,	,	PUNCT
fnp-6282	122	4	a	a	DET
fnp-6282	122	5	similar	similar	ADJ
fnp-6282	122	6	interaction	interaction	NOUN
fnp-6282	122	7	between	between	ADP
fnp-6282	122	8	impdh	impdh	NOUN
fnp-6282	122	9	and	and	CCONJ
fnp-6282	122	10	the	the	DET
fnp-6282	122	11	pyrimidine	pyrimidine	NOUN
fnp-6282	122	12	-	-	PUNCT
fnp-6282	122	13	synthesizing	synthesize	VERB
fnp-6282	122	14	enzyme	enzyme	NOUN
fnp-6282	122	15	cytidine	cytidine	NOUN
fnp-6282	122	16	triphosphate	triphosphate	NOUN
fnp-6282	122	17	synthase	synthase	NOUN
fnp-6282	122	18	(	(	PUNCT
fnp-6282	122	19	ctps	ctps	NOUN
fnp-6282	122	20	)	)	PUNCT
fnp-6282	122	21	in	in	ADP
fnp-6282	122	22	cytoophidia	cytoophidia	PROPN
fnp-6282	122	23	has	have	AUX
fnp-6282	122	24	been	be	AUX
fnp-6282	122	25	implicated	implicate	VERB
fnp-6282	122	26	as	as	ADP
fnp-6282	122	27	a	a	DET
fnp-6282	122	28	substrate	substrate	NOUN
fnp-6282	122	29	to	to	PART
fnp-6282	122	30	co	co	VERB
fnp-6282	122	31	-	-	VERB
fnp-6282	122	32	ordinate	ordinate	VERB
fnp-6282	122	33	the	the	DET
fnp-6282	122	34	cross	cross	NOUN
fnp-6282	122	35	-	-	NOUN
fnp-6282	122	36	regulation	regulation	NOUN
fnp-6282	122	37	of	of	ADP
fnp-6282	122	38	purine	purine	NOUN
fnp-6282	122	39	and	and	CCONJ
fnp-6282	122	40	pyrimidine	pyrimidine	ADJ
fnp-6282	122	41	nucleotide	nucleotide	ADJ
fnp-6282	122	42	synthesis	synthesis	NOUN
fnp-6282	122	43	[	[	X
fnp-6282	122	44	14	14	NUM
fnp-6282	122	45	]	]	PUNCT
fnp-6282	122	46	.	.	PUNCT
fnp-6282	123	1	in	in	ADP
fnp-6282	123	2	a	a	DET
fnp-6282	123	3	screen	screen	NOUN
fnp-6282	123	4	of	of	ADP
fnp-6282	123	5	440	440	NUM
fnp-6282	123	6	yeast	yeast	NOUN
fnp-6282	123	7	metabolic	metabolic	NOUN
fnp-6282	123	8	enzymes	enzyme	NOUN
fnp-6282	123	9	,	,	PUNCT
fnp-6282	123	10	noree	noree	PROPN
fnp-6282	123	11	et	et	PROPN
fnp-6282	123	12	al	al	PROPN
fnp-6282	123	13	.	.	PROPN
fnp-6282	123	14	showed	show	VERB
fnp-6282	123	15	the	the	DET
fnp-6282	123	16	assembly	assembly	NOUN
fnp-6282	123	17	of	of	ADP
fnp-6282	123	18	multiple	multiple	ADJ
fnp-6282	123	19	metabolic	metabolic	NOUN
fnp-6282	123	20	enzymes	enzyme	NOUN
fnp-6282	123	21	into	into	ADP
fnp-6282	123	22	rod	rod	NOUN
fnp-6282	123	23	-	-	PUNCT
fnp-6282	123	24	shaped	shape	VERB
fnp-6282	123	25	structures	structure	NOUN
fnp-6282	123	26	[	[	X
fnp-6282	123	27	50	50	NUM
fnp-6282	123	28	]	]	PUNCT
fnp-6282	123	29	.	.	PUNCT
fnp-6282	124	1	interestingly	interestingly	ADV
fnp-6282	124	2	,	,	PUNCT
fnp-6282	124	3	enzymes	enzyme	NOUN
fnp-6282	124	4	that	that	PRON
fnp-6282	124	5	co	co	VERB
fnp-6282	124	6	-	-	VERB
fnp-6282	124	7	assembled	assemble	VERB
fnp-6282	124	8	,	,	PUNCT
fnp-6282	124	9	like	like	ADP
fnp-6282	124	10	impdh	impdh	NOUN
fnp-6282	124	11	and	and	CCONJ
fnp-6282	124	12	prps	prps	PROPN
fnp-6282	124	13	,	,	PUNCT
fnp-6282	124	14	were	be	AUX
fnp-6282	124	15	those	those	PRON
fnp-6282	124	16	that	that	PRON
fnp-6282	124	17	acted	act	VERB
fnp-6282	124	18	at	at	ADP
fnp-6282	124	19	branch	branch	NOUN
fnp-6282	124	20	points	point	NOUN
fnp-6282	124	21	within	within	ADP
fnp-6282	124	22	the	the	DET
fnp-6282	124	23	de	de	X
fnp-6282	124	24	novo	novo	NOUN
fnp-6282	124	25	purine	purine	NOUN
fnp-6282	124	26	biosynthetic	biosynthetic	ADJ
fnp-6282	124	27	pathway	pathway	NOUN
fnp-6282	124	28	,	,	PUNCT
fnp-6282	124	29	further	far	ADV
fnp-6282	124	30	suggesting	suggest	VERB
fnp-6282	124	31	that	that	SCONJ
fnp-6282	124	32	this	this	DET
fnp-6282	124	33	co	co	NOUN
fnp-6282	124	34	-	-	NOUN
fnp-6282	124	35	localization	localization	NOUN
fnp-6282	124	36	reflects	reflect	VERB
fnp-6282	124	37	some	some	DET
fnp-6282	124	38	form	form	NOUN
fnp-6282	124	39	of	of	ADP
fnp-6282	124	40	regulatory	regulatory	ADJ
fnp-6282	124	41	mechanism	mechanism	NOUN
fnp-6282	124	42	in	in	ADP
fnp-6282	124	43	the	the	DET
fnp-6282	124	44	nucleotide	nucleotide	ADJ
fnp-6282	124	45	biosynthetic	biosynthetic	ADJ
fnp-6282	124	46	pathway	pathway	NOUN
fnp-6282	124	47	.	.	PUNCT
fnp-6282	125	1	the	the	DET
fnp-6282	125	2	majority	majority	NOUN
fnp-6282	125	3	of	of	ADP
fnp-6282	125	4	mechanistic	mechanistic	ADJ
fnp-6282	125	5	studies	study	NOUN
fnp-6282	125	6	have	have	AUX
fnp-6282	125	7	linked	link	VERB
fnp-6282	125	8	cytoophidia	cytoophidia	NOUN
fnp-6282	125	9	formation	formation	NOUN
fnp-6282	125	10	to	to	ADP
fnp-6282	125	11	the	the	DET
fnp-6282	125	12	dynamic	dynamic	ADJ
fnp-6282	125	13	regulation	regulation	NOUN
fnp-6282	125	14	of	of	ADP
fnp-6282	125	15	enzyme	enzyme	NOUN
fnp-6282	125	16	activity	activity	NOUN
fnp-6282	125	17	and	and	CCONJ
fnp-6282	125	18	thus	thus	ADV
fnp-6282	125	19	,	,	PUNCT
fnp-6282	125	20	in	in	ADP
fnp-6282	125	21	the	the	DET
fnp-6282	125	22	case	case	NOUN
fnp-6282	125	23	of	of	ADP
fnp-6282	125	24	prps	prps	PROPN
fnp-6282	125	25	(	(	PUNCT
fnp-6282	125	26	with	with	ADP
fnp-6282	125	27	impdh	impdh	NOUN
fnp-6282	125	28	)	)	PUNCT
fnp-6282	125	29	,	,	PUNCT
fnp-6282	125	30	to	to	ADP
fnp-6282	125	31	the	the	DET
fnp-6282	125	32	synthesis	synthesis	NOUN
fnp-6282	125	33	of	of	ADP
fnp-6282	125	34	purine	purine	NOUN
fnp-6282	125	35	nucleotides	nucleotide	NOUN
fnp-6282	125	36	.	.	PUNCT
fnp-6282	126	1	purine	purine	NOUN
fnp-6282	126	2	nucleotides	nucleotide	NOUN
fnp-6282	126	3	are	be	AUX
fnp-6282	126	4	essential	essential	ADJ
fnp-6282	126	5	for	for	ADP
fnp-6282	126	6	the	the	DET
fnp-6282	126	7	proper	proper	ADJ
fnp-6282	126	8	development	development	NOUN
fnp-6282	126	9	and	and	CCONJ
fnp-6282	126	10	maintenance	maintenance	NOUN
fnp-6282	126	11	of	of	ADP
fnp-6282	126	12	the	the	DET
fnp-6282	126	13	brain	brain	NOUN
fnp-6282	126	14	.	.	PUNCT
fnp-6282	127	1	guanine	guanine	NOUN
fnp-6282	127	2	-	-	PUNCT
fnp-6282	127	3	based	base	VERB
fnp-6282	127	4	purines	purine	NOUN
fnp-6282	127	5	,	,	PUNCT
fnp-6282	127	6	and	and	CCONJ
fnp-6282	127	7	especially	especially	ADV
fnp-6282	127	8	gtp	gtp	NOUN
fnp-6282	127	9	and	and	CCONJ
fnp-6282	127	10	its	its	PRON
fnp-6282	127	11	breakdown	breakdown	ADJ
fnp-6282	127	12	product	product	NOUN
fnp-6282	127	13	guanosine	guanosine	NOUN
fnp-6282	127	14	,	,	PUNCT
fnp-6282	127	15	have	have	VERB
fnp-6282	127	16	neuromodulatory	neuromodulatory	ADJ
fnp-6282	127	17	properties	property	NOUN
fnp-6282	127	18	(	(	PUNCT
fnp-6282	127	19	reviewed	review	VERB
fnp-6282	127	20	in	in	ADP
fnp-6282	127	21	[	[	X
fnp-6282	127	22	59	59	NUM
fnp-6282	127	23	]	]	PUNCT
fnp-6282	127	24	)	)	PUNCT
fnp-6282	127	25	with	with	ADP
fnp-6282	127	26	neuroprotective	neuroprotective	ADJ
fnp-6282	127	27	,	,	PUNCT
fnp-6282	127	28	neurotrophic	neurotrophic	NOUN
fnp-6282	127	29	,	,	PUNCT
fnp-6282	127	30	and	and	CCONJ
fnp-6282	127	31	neuritogenic	neuritogenic	ADJ
fnp-6282	127	32	capacity	capacity	NOUN
fnp-6282	127	33	[	[	X
fnp-6282	127	34	23	23	NUM
fnp-6282	127	35	,	,	PUNCT
fnp-6282	127	36	24	24	NUM
fnp-6282	127	37	,	,	PUNCT
fnp-6282	127	38	49	49	NUM
fnp-6282	127	39	,	,	PUNCT
fnp-6282	127	40	59	59	NUM
fnp-6282	127	41	]	]	PUNCT
fnp-6282	127	42	.	.	PUNCT
fnp-6282	128	1	these	these	PRON
fnp-6282	128	2	are	be	AUX
fnp-6282	128	3	mediated	mediate	VERB
fnp-6282	128	4	through	through	ADP
fnp-6282	128	5	intracellular	intracellular	ADJ
fnp-6282	128	6	modulation	modulation	NOUN
fnp-6282	128	7	of	of	ADP
fnp-6282	128	8	g	g	NOUN
fnp-6282	128	9	-	-	PUNCT
fnp-6282	128	10	proteins	protein	NOUN
fnp-6282	128	11	as	as	ADV
fnp-6282	128	12	well	well	ADV
fnp-6282	128	13	as	as	ADP
fnp-6282	128	14	via	via	ADP
fnp-6282	128	15	extracellular	extracellular	ADJ
fnp-6282	128	16	signaling	signal	VERB
fnp-6282	128	17	by	by	ADP
fnp-6282	128	18	purines	purine	NOUN
fnp-6282	128	19	themselves	themselves	PRON
fnp-6282	128	20	[	[	X
fnp-6282	128	21	59	59	NUM
fnp-6282	128	22	]	]	PUNCT
fnp-6282	128	23	.	.	PUNCT
fnp-6282	129	1	gtp	gtp	NOUN
fnp-6282	129	2	plays	play	VERB
fnp-6282	129	3	a	a	DET
fnp-6282	129	4	critical	critical	ADJ
fnp-6282	129	5	role	role	NOUN
fnp-6282	129	6	in	in	ADP
fnp-6282	129	7	tubulin	tubulin	NOUN
fnp-6282	129	8	polymerization	polymerization	NOUN
fnp-6282	129	9	for	for	ADP
fnp-6282	129	10	microtubule	microtubule	NOUN
fnp-6282	129	11	growth	growth	NOUN
fnp-6282	129	12	[	[	X
fnp-6282	129	13	13	13	NUM
fnp-6282	129	14	]	]	PUNCT
fnp-6282	129	15	and	and	CCONJ
fnp-6282	129	16	is	be	AUX
fnp-6282	129	17	a	a	DET
fnp-6282	129	18	substrate	substrate	NOUN
fnp-6282	129	19	for	for	ADP
fnp-6282	129	20	the	the	DET
fnp-6282	129	21	multitude	multitude	NOUN
fnp-6282	129	22	of	of	ADP
fnp-6282	129	23	small	small	ADJ
fnp-6282	129	24	gtpases	gtpase	NOUN
fnp-6282	129	25	involved	involve	VERB
fnp-6282	129	26	in	in	ADP
fnp-6282	129	27	neurite	neurite	ADJ
fnp-6282	129	28	growth	growth	NOUN
fnp-6282	129	29	and	and	CCONJ
fnp-6282	129	30	synaptogenesis	synaptogenesis	NOUN
fnp-6282	129	31	[	[	X
fnp-6282	129	32	19	19	NUM
fnp-6282	129	33	,	,	PUNCT
fnp-6282	129	34	61	61	NUM
fnp-6282	129	35	]	]	PUNCT
fnp-6282	129	36	.	.	PUNCT
fnp-6282	130	1	our	our	PRON
fnp-6282	130	2	findings	finding	NOUN
fnp-6282	130	3	are	be	AUX
fnp-6282	130	4	consistent	consistent	ADJ
fnp-6282	130	5	with	with	ADP
fnp-6282	130	6	evidence	evidence	NOUN
fnp-6282	130	7	for	for	ADP
fnp-6282	130	8	the	the	DET
fnp-6282	130	9	involvement	involvement	NOUN
fnp-6282	130	10	of	of	ADP
fnp-6282	130	11	nucleotide	nucleotide	NOUN
fnp-6282	130	12	-	-	PUNCT
fnp-6282	130	13	synthesizing	synthesize	VERB
fnp-6282	130	14	enzymes	enzyme	NOUN
fnp-6282	130	15	,	,	PUNCT
fnp-6282	130	16	and	and	CCONJ
fnp-6282	130	17	possibly	possibly	ADV
fnp-6282	130	18	their	their	PRON
fnp-6282	130	19	filamentation	filamentation	NOUN
fnp-6282	130	20	,	,	PUNCT
fnp-6282	130	21	in	in	ADP
fnp-6282	130	22	neurological	neurological	ADJ
fnp-6282	130	23	diseases	disease	NOUN
fnp-6282	130	24	[	[	X
fnp-6282	130	25	27	27	NUM
fnp-6282	130	26	]	]	PUNCT
fnp-6282	130	27	.	.	PUNCT
fnp-6282	131	1	loss	loss	NOUN
fnp-6282	131	2	-	-	PUNCT
fnp-6282	131	3	of	of	ADP
fnp-6282	131	4	-	-	PUNCT
fnp-6282	131	5	function	function	NOUN
fnp-6282	131	6	mutations	mutation	NOUN
fnp-6282	131	7	in	in	ADP
fnp-6282	131	8	prps1	prps1	NOUN
fnp-6282	131	9	(	(	PUNCT
fnp-6282	131	10	encoded	encode	VERB
fnp-6282	131	11	on	on	ADP
fnp-6282	131	12	the	the	DET
fnp-6282	131	13	x	x	NOUN
fnp-6282	131	14	-	-	NOUN
fnp-6282	131	15	chromosome	chromosome	NOUN
fnp-6282	131	16	)	)	PUNCT
fnp-6282	131	17	,	,	PUNCT
fnp-6282	131	18	culminate	culminate	NOUN
fnp-6282	131	19	in	in	ADP
fnp-6282	131	20	a	a	DET
fnp-6282	131	21	constellation	constellation	NOUN
fnp-6282	131	22	of	of	ADP
fnp-6282	131	23	neurodevelopmental	neurodevelopmental	ADJ
fnp-6282	131	24	symptoms	symptom	NOUN
fnp-6282	131	25	in	in	ADP
fnp-6282	131	26	males	male	NOUN
fnp-6282	131	27	referred	refer	VERB
fnp-6282	131	28	to	to	ADP
fnp-6282	131	29	eponymously	eponymously	ADV
fnp-6282	131	30	as	as	ADP
fnp-6282	131	31	arts	art	NOUN
fnp-6282	131	32	syndrome	syndrome	NOUN
fnp-6282	131	33	and	and	CCONJ
fnp-6282	131	34	encompassing	encompass	VERB
fnp-6282	131	35	sensorineural	sensorineural	ADJ
fnp-6282	131	36	hearing	hearing	NOUN
fnp-6282	131	37	loss	loss	NOUN
fnp-6282	131	38	,	,	PUNCT
fnp-6282	131	39	hypotonia	hypotonia	NOUN
fnp-6282	131	40	,	,	PUNCT
fnp-6282	131	41	ataxia	ataxia	NOUN
fnp-6282	131	42	,	,	PUNCT
fnp-6282	131	43	developmental	developmental	ADJ
fnp-6282	131	44	delay	delay	NOUN
fnp-6282	131	45	,	,	PUNCT
fnp-6282	131	46	and	and	CCONJ
fnp-6282	131	47	intellectual	intellectual	ADJ
fnp-6282	131	48	disability	disability	NOUN
fnp-6282	132	1	[	[	X
fnp-6282	132	2	16	16	NUM
fnp-6282	132	3	,	,	PUNCT
fnp-6282	132	4	17	17	NUM
fnp-6282	132	5	]	]	PUNCT
fnp-6282	132	6	.	.	PUNCT
fnp-6282	133	1	similarly	similarly	ADV
fnp-6282	133	2	,	,	PUNCT
fnp-6282	133	3	mutations	mutation	NOUN
fnp-6282	133	4	in	in	ADP
fnp-6282	133	5	impdh2	impdh2	PROPN
fnp-6282	133	6	result	result	VERB
fnp-6282	133	7	in	in	ADP
fnp-6282	133	8	variable	variable	ADJ
fnp-6282	133	9	combinations	combination	NOUN
fnp-6282	133	10	of	of	ADP
fnp-6282	133	11	intellectual	intellectual	ADJ
fnp-6282	133	12	disability	disability	NOUN
fnp-6282	133	13	,	,	PUNCT
fnp-6282	133	14	speech	speech	NOUN
fnp-6282	133	15	impairment	impairment	NOUN
fnp-6282	133	16	,	,	PUNCT
fnp-6282	133	17	hand	hand	NOUN
fnp-6282	133	18	tremor	tremor	NOUN
fnp-6282	133	19	,	,	PUNCT
fnp-6282	133	20	gait	gait	NOUN
fnp-6282	133	21	instability	instability	NOUN
fnp-6282	133	22	,	,	PUNCT
fnp-6282	133	23	and	and	CCONJ
fnp-6282	133	24	dystonia	dystonia	NOUN
fnp-6282	134	1	[	[	X
fnp-6282	134	2	51	51	NUM
fnp-6282	134	3	,	,	PUNCT
fnp-6282	134	4	52	52	NUM
fnp-6282	134	5	,	,	PUNCT
fnp-6282	134	6	66	66	NUM
fnp-6282	134	7	]	]	PUNCT
fnp-6282	134	8	.	.	PUNCT
fnp-6282	135	1	why	why	SCONJ
fnp-6282	135	2	mutations	mutation	NOUN
fnp-6282	135	3	in	in	ADP
fnp-6282	135	4	these	these	DET
fnp-6282	135	5	enzymes	enzyme	NOUN
fnp-6282	135	6	have	have	VERB
fnp-6282	135	7	a	a	DET
fnp-6282	135	8	relatively	relatively	ADV
fnp-6282	135	9	selective	selective	ADJ
fnp-6282	135	10	impact	impact	NOUN
fnp-6282	135	11	on	on	ADP
fnp-6282	135	12	the	the	DET
fnp-6282	135	13	nervous	nervous	ADJ
fnp-6282	135	14	system	system	NOUN
fnp-6282	135	15	despite	despite	SCONJ
fnp-6282	135	16	their	their	PRON
fnp-6282	135	17	widespread	widespread	ADJ
fnp-6282	135	18	systemic	systemic	ADJ
fnp-6282	135	19	expression	expression	NOUN
fnp-6282	135	20	has	have	AUX
fnp-6282	135	21	not	not	PART
fnp-6282	135	22	been	be	AUX
fnp-6282	135	23	adequately	adequately	ADV
fnp-6282	135	24	explained	explain	VERB
fnp-6282	135	25	.	.	PUNCT
fnp-6282	136	1	the	the	DET
fnp-6282	136	2	relatively	relatively	ADV
fnp-6282	136	3	selective	selective	ADJ
fnp-6282	136	4	localization	localization	NOUN
fnp-6282	136	5	of	of	ADP
fnp-6282	136	6	ncs	ncs	NOUN
fnp-6282	136	7	to	to	ADP
fnp-6282	136	8	the	the	DET
fnp-6282	136	9	brain	brain	NOUN
fnp-6282	136	10	despite	despite	SCONJ
fnp-6282	136	11	the	the	DET
fnp-6282	136	12	widespread	widespread	ADJ
fnp-6282	136	13	expression	expression	NOUN
fnp-6282	136	14	of	of	ADP
fnp-6282	136	15	their	their	PRON
fnp-6282	136	16	constituent	constituent	ADJ
fnp-6282	136	17	enzymes	enzyme	NOUN
fnp-6282	136	18	is	be	AUX
fnp-6282	136	19	provocative	provocative	ADJ
fnp-6282	136	20	in	in	ADP
fnp-6282	136	21	this	this	DET
fnp-6282	136	22	regard	regard	NOUN
fnp-6282	136	23	.	.	PUNCT
fnp-6282	137	1	intriguingly	intriguingly	ADV
fnp-6282	137	2	,	,	PUNCT
fnp-6282	137	3	a	a	DET
fnp-6282	137	4	proportion	proportion	NOUN
fnp-6282	137	5	of	of	ADP
fnp-6282	137	6	the	the	DET
fnp-6282	137	7	disease	disease	NOUN
fnp-6282	137	8	-	-	PUNCT
fnp-6282	137	9	causing	cause	VERB
fnp-6282	137	10	mutations	mutation	NOUN
fnp-6282	137	11	in	in	ADP
fnp-6282	137	12	both	both	DET
fnp-6282	137	13	prps1	prps1	NOUN
fnp-6282	137	14	,	,	PUNCT
fnp-6282	137	15	as	as	ADV
fnp-6282	137	16	well	well	ADV
fnp-6282	137	17	as	as	ADP
fnp-6282	137	18	impdh	impdh	NOUN
fnp-6282	137	19	alter	alter	NOUN
fnp-6282	137	20	filament	filament	NOUN
fnp-6282	137	21	assembly	assembly	NOUN
fnp-6282	138	1	[	[	X
fnp-6282	138	2	25	25	NUM
fnp-6282	138	3	,	,	PUNCT
fnp-6282	138	4	52	52	NUM
fnp-6282	138	5	]	]	PUNCT
fnp-6282	138	6	,	,	PUNCT
fnp-6282	138	7	suggesting	suggest	VERB
fnp-6282	138	8	a	a	DET
fnp-6282	138	9	beneficial	beneficial	ADJ
fnp-6282	138	10	role	role	NOUN
fnp-6282	138	11	for	for	ADP
fnp-6282	138	12	filament	filament	NOUN
fnp-6282	138	13	formation	formation	NOUN
fnp-6282	138	14	.	.	PUNCT
fnp-6282	139	1	consistent	consistent	ADJ
fnp-6282	139	2	with	with	ADP
fnp-6282	139	3	this	this	PRON
fnp-6282	139	4	,	,	PUNCT
fnp-6282	139	5	flores	flores	PROPN
fnp-6282	139	6	-	-	PUNCT
fnp-6282	139	7	mendez	mendez	PROPN
fnp-6282	139	8	and	and	CCONJ
fnp-6282	139	9	co	co	NOUN
fnp-6282	139	10	-	-	NOUN
fnp-6282	139	11	workers	worker	NOUN
fnp-6282	139	12	recently	recently	ADV
fnp-6282	139	13	demonstrated	demonstrate	VERB
fnp-6282	139	14	a	a	DET
fnp-6282	139	15	neuroprotective	neuroprotective	ADJ
fnp-6282	139	16	role	role	NOUN
fnp-6282	139	17	for	for	ADP
fnp-6282	139	18	impdh2	impdh2	PROPN
fnp-6282	139	19	filament	filament	NOUN
fnp-6282	139	20	formation	formation	NOUN
fnp-6282	139	21	in	in	ADP
fnp-6282	139	22	neurodegeneration	neurodegeneration	NOUN
fnp-6282	139	23	[	[	X
fnp-6282	139	24	21	21	NUM
fnp-6282	139	25	]	]	PUNCT
fnp-6282	139	26	.	.	PUNCT
fnp-6282	140	1	understanding	understand	VERB
fnp-6282	140	2	the	the	DET
fnp-6282	140	3	mechanisms	mechanism	NOUN
fnp-6282	140	4	through	through	ADP
fnp-6282	140	5	which	which	PRON
fnp-6282	140	6	ncs	ncs	NOUN
fnp-6282	140	7	might	might	AUX
fnp-6282	140	8	contribute	contribute	VERB
fnp-6282	140	9	to	to	ADP
fnp-6282	140	10	ad	ad	NOUN
fnp-6282	140	11	pathogenesis	pathogenesis	NOUN
fnp-6282	140	12	is	be	AUX
fnp-6282	140	13	predicated	predicate	VERB
fnp-6282	140	14	on	on	ADP
fnp-6282	140	15	elucidating	elucidate	VERB
fnp-6282	140	16	their	their	PRON
fnp-6282	140	17	physiological	physiological	ADJ
fnp-6282	140	18	significance	significance	NOUN
fnp-6282	140	19	in	in	ADP
fnp-6282	140	20	neurons	neuron	NOUN
fnp-6282	140	21	,	,	PUNCT
fnp-6282	140	22	which	which	PRON
fnp-6282	140	23	is	be	AUX
fnp-6282	140	24	currently	currently	ADV
fnp-6282	140	25	unknown	unknown	ADJ
fnp-6282	140	26	.	.	PUNCT
fnp-6282	141	1	a	a	DET
fnp-6282	141	2	canonical	canonical	ADJ
fnp-6282	141	3	role	role	NOUN
fnp-6282	141	4	for	for	ADP
fnp-6282	141	5	prps	prps	PROPN
fnp-6282	141	6	filaments	filament	NOUN
fnp-6282	141	7	in	in	ADP
fnp-6282	141	8	regulating	regulate	VERB
fnp-6282	141	9	enzyme	enzyme	NOUN
fnp-6282	141	10	activity	activity	NOUN
fnp-6282	141	11	makes	make	VERB
fnp-6282	141	12	sense	sense	NOUN
fnp-6282	141	13	in	in	ADP
fnp-6282	141	14	the	the	DET
fnp-6282	141	15	cytoplasmic	cytoplasmic	ADJ
fnp-6282	141	16	compartment	compartment	NOUN
fnp-6282	141	17	where	where	SCONJ
fnp-6282	141	18	nucleotides	nucleotide	NOUN
fnp-6282	141	19	are	be	AUX
fnp-6282	141	20	synthesized	synthesize	VERB
fnp-6282	141	21	.	.	PUNCT
fnp-6282	142	1	indeed	indeed	ADV
fnp-6282	142	2	,	,	PUNCT
fnp-6282	142	3	we	we	PRON
fnp-6282	142	4	postulate	postulate	VERB
fnp-6282	142	5	that	that	SCONJ
fnp-6282	142	6	the	the	DET
fnp-6282	142	7	small	small	ADJ
fnp-6282	142	8	cytoplasmic	cytoplasmic	ADJ
fnp-6282	142	9	filaments	filament	NOUN
fnp-6282	142	10	we	we	PRON
fnp-6282	142	11	describe	describe	VERB
fnp-6282	142	12	herein	herein	NOUN
fnp-6282	142	13	are	be	AUX
fnp-6282	142	14	engaged	engage	VERB
fnp-6282	142	15	in	in	ADP
fnp-6282	142	16	this	this	PRON
fnp-6282	142	17	,	,	PUNCT
fnp-6282	142	18	perhaps	perhaps	ADV
fnp-6282	142	19	in	in	ADP
fnp-6282	142	20	association	association	NOUN
fnp-6282	142	21	with	with	ADP
fnp-6282	142	22	mitochondria	mitochondria	PROPN
fnp-6282	142	23	(	(	PUNCT
fnp-6282	142	24	see	see	VERB
fnp-6282	142	25	[	[	X
fnp-6282	142	26	64	64	NUM
fnp-6282	142	27	]	]	PUNCT
fnp-6282	142	28	)	)	PUNCT
fnp-6282	142	29	,	,	PUNCT
fnp-6282	142	30	by	by	ADP
fnp-6282	142	31	analogy	analogy	NOUN
fnp-6282	142	32	with	with	ADP
fnp-6282	142	33	purinosomes	purinosome	NOUN
fnp-6282	143	1	[	[	X
fnp-6282	143	2	22	22	NUM
fnp-6282	143	3	]	]	PUNCT
fnp-6282	143	4	.	.	PUNCT
fnp-6282	144	1	on	on	ADP
fnp-6282	144	2	the	the	DET
fnp-6282	144	3	other	other	ADJ
fnp-6282	144	4	hand	hand	NOUN
fnp-6282	144	5	,	,	PUNCT
fnp-6282	144	6	the	the	DET
fnp-6282	144	7	functional	functional	ADJ
fnp-6282	144	8	significance	significance	NOUN
fnp-6282	144	9	of	of	ADP
fnp-6282	144	10	prps1	prps1	NOUN
fnp-6282	144	11	filament	filament	NOUN
fnp-6282	144	12	assemblies	assembly	NOUN
fnp-6282	144	13	within	within	ADP
fnp-6282	144	14	the	the	DET
fnp-6282	144	15	nuclear	nuclear	ADJ
fnp-6282	144	16	compartment	compartment	NOUN
fnp-6282	144	17	of	of	ADP
fnp-6282	144	18	neurons	neuron	NOUN
fnp-6282	144	19	remains	remain	VERB
fnp-6282	144	20	to	to	PART
fnp-6282	144	21	be	be	AUX
fnp-6282	144	22	explored	explore	VERB
fnp-6282	144	23	.	.	PUNCT
fnp-6282	145	1	there	there	PRON
fnp-6282	145	2	is	be	VERB
fnp-6282	145	3	evidence	evidence	NOUN
fnp-6282	145	4	that	that	SCONJ
fnp-6282	145	5	prps	prps	PROPN
fnp-6282	145	6	,	,	PUNCT
fnp-6282	145	7	as	as	ADV
fnp-6282	145	8	well	well	ADV
fnp-6282	145	9	as	as	ADP
fnp-6282	145	10	impdh	impdh	NOUN
fnp-6282	145	11	,	,	PUNCT
fnp-6282	145	12	can	can	AUX
fnp-6282	145	13	localize	localize	VERB
fnp-6282	145	14	to	to	ADP
fnp-6282	145	15	the	the	DET
fnp-6282	145	16	nucleus	nucleus	NOUN
fnp-6282	145	17	[	[	X
fnp-6282	145	18	32	32	NUM
fnp-6282	145	19	,	,	PUNCT
fnp-6282	145	20	37	37	NUM
fnp-6282	145	21	]	]	PUNCT
fnp-6282	145	22	.	.	PUNCT
fnp-6282	146	1	we	we	PRON
fnp-6282	146	2	have	have	AUX
fnp-6282	146	3	described	describe	VERB
fnp-6282	146	4	the	the	DET
fnp-6282	146	5	presence	presence	NOUN
fnp-6282	146	6	of	of	ADP
fnp-6282	146	7	impdh	impdh	NOUN
fnp-6282	146	8	ncs	ncs	NOUN
fnp-6282	146	9	within	within	ADP
fnp-6282	146	10	the	the	DET
fnp-6282	146	11	nuclei	nucleus	NOUN
fnp-6282	146	12	of	of	ADP
fnp-6282	146	13	substantia	substantia	PROPN
fnp-6282	146	14	nigra	nigra	NOUN
fnp-6282	146	15	neurons	neuron	NOUN
fnp-6282	146	16	where	where	SCONJ
fnp-6282	146	17	they	they	PRON
fnp-6282	146	18	display	display	VERB
fnp-6282	146	19	marked	mark	VERB
fnp-6282	146	20	age	age	NOUN
fnp-6282	146	21	-	-	PUNCT
fnp-6282	146	22	associated	associate	VERB
fnp-6282	146	23	morphological	morphological	ADJ
fnp-6282	146	24	alterations	alteration	NOUN
fnp-6282	146	25	[	[	X
fnp-6282	146	26	64	64	NUM
fnp-6282	146	27	]	]	PUNCT
fnp-6282	146	28	.	.	PUNCT
fnp-6282	147	1	prps1	prps1	NOUN
fnp-6282	147	2	-	-	PUNCT
fnp-6282	147	3	immunoreactive	immunoreactive	ADJ
fnp-6282	147	4	rods	rod	NOUN
fnp-6282	147	5	have	have	AUX
fnp-6282	147	6	also	also	ADV
fnp-6282	147	7	been	be	AUX
fnp-6282	147	8	described	describe	VERB
fnp-6282	147	9	in	in	ADP
fnp-6282	147	10	the	the	DET
fnp-6282	147	11	nucleus	nucleus	NOUN
fnp-6282	147	12	of	of	ADP
fnp-6282	147	13	neurons	neuron	NOUN
fnp-6282	147	14	in	in	ADP
fnp-6282	147	15	vitro	vitro	X
fnp-6282	147	16	[	[	X
fnp-6282	147	17	50	50	NUM
fnp-6282	147	18	]	]	PUNCT
fnp-6282	147	19	and	and	CCONJ
fnp-6282	147	20	in	in	ADP
fnp-6282	147	21	vivo	vivo	NOUN
fnp-6282	147	22	[	[	X
fnp-6282	147	23	63	63	NUM
fnp-6282	147	24	]	]	PUNCT
fnp-6282	147	25	.	.	PUNCT
fnp-6282	148	1	this	this	PRON
fnp-6282	148	2	is	be	AUX
fnp-6282	148	3	consistent	consistent	ADJ
fnp-6282	148	4	with	with	ADP
fnp-6282	148	5	evidence	evidence	NOUN
fnp-6282	148	6	for	for	ADP
fnp-6282	148	7	a	a	DET
fnp-6282	148	8	nuclear	nuclear	ADJ
fnp-6282	148	9	localization	localization	NOUN
fnp-6282	148	10	and	and	CCONJ
fnp-6282	148	11	function	function	NOUN
fnp-6282	148	12	of	of	ADP
fnp-6282	148	13	a	a	DET
fnp-6282	148	14	growing	grow	VERB
fnp-6282	148	15	number	number	NOUN
fnp-6282	148	16	of	of	ADP
fnp-6282	148	17	metabolic	metabolic	NOUN
fnp-6282	148	18	enzymes	enzyme	NOUN
fnp-6282	148	19	[	[	X
fnp-6282	148	20	7	7	NUM
fnp-6282	148	21	]	]	PUNCT
fnp-6282	148	22	.	.	PUNCT
fnp-6282	149	1	we	we	PRON
fnp-6282	149	2	propose	propose	VERB
fnp-6282	149	3	two	two	NUM
fnp-6282	149	4	non	non	ADJ
fnp-6282	149	5	-	-	ADJ
fnp-6282	149	6	mutually	mutually	ADV
fnp-6282	149	7	exclusive	exclusive	ADJ
fnp-6282	149	8	possibilities	possibility	NOUN
fnp-6282	149	9	regarding	regard	VERB
fnp-6282	149	10	the	the	DET
fnp-6282	149	11	significance	significance	NOUN
fnp-6282	149	12	of	of	ADP
fnp-6282	149	13	prps	prps	PROPN
fnp-6282	149	14	/	/	SYM
fnp-6282	149	15	impdh	impdh	NOUN
fnp-6282	149	16	rods	rod	NOUN
fnp-6282	149	17	in	in	ADP
fnp-6282	149	18	the	the	DET
fnp-6282	149	19	nuclear	nuclear	ADJ
fnp-6282	149	20	compartment	compartment	NOUN
fnp-6282	149	21	.	.	PUNCT
fnp-6282	150	1	first	first	ADV
fnp-6282	150	2	,	,	PUNCT
fnp-6282	150	3	it	it	PRON
fnp-6282	150	4	is	be	AUX
fnp-6282	150	5	conceivable	conceivable	ADJ
fnp-6282	150	6	that	that	SCONJ
fnp-6282	150	7	ncs	nc	NOUN
fnp-6282	150	8	regulate	regulate	VERB
fnp-6282	150	9	the	the	DET
fnp-6282	150	10	synthesis	synthesis	NOUN
fnp-6282	150	11	of	of	ADP
fnp-6282	150	12	purines	purine	NOUN
fnp-6282	150	13	within	within	ADP
fnp-6282	150	14	the	the	DET
fnp-6282	150	15	nucleus	nucleus	NOUN
fnp-6282	150	16	,	,	PUNCT
fnp-6282	150	17	providing	provide	VERB
fnp-6282	150	18	a	a	DET
fnp-6282	150	19	proximate	proximate	NOUN
fnp-6282	150	20	,	,	PUNCT
fnp-6282	150	21	"	"	PUNCT
fnp-6282	150	22	hyperlocal	hyperlocal	ADJ
fnp-6282	150	23	"	"	PUNCT
fnp-6282	150	24	source	source	NOUN
fnp-6282	150	25	of	of	ADP
fnp-6282	150	26	nucleotides	nucleotide	NOUN
fnp-6282	150	27	at	at	ADP
fnp-6282	150	28	loci	loci	NOUN
fnp-6282	150	29	of	of	ADP
fnp-6282	150	30	high	high	ADJ
fnp-6282	150	31	nucleotide	nucleotide	NOUN
fnp-6282	150	32	demand	demand	NOUN
fnp-6282	150	33	.	.	PUNCT
fnp-6282	151	1	indeed	indeed	ADV
fnp-6282	151	2	,	,	PUNCT
fnp-6282	151	3	previous	previous	ADJ
fnp-6282	151	4	reports	report	NOUN
fnp-6282	151	5	have	have	AUX
fnp-6282	151	6	shown	show	VERB
fnp-6282	151	7	that	that	SCONJ
fnp-6282	151	8	impdh	impdh	NOUN
fnp-6282	151	9	localization	localization	NOUN
fnp-6282	151	10	is	be	AUX
fnp-6282	151	11	responsive	responsive	ADJ
fnp-6282	151	12	to	to	ADP
fnp-6282	151	13	gtp	gtp	NOUN
fnp-6282	151	14	demand	demand	NOUN
fnp-6282	151	15	and	and	CCONJ
fnp-6282	151	16	that	that	SCONJ
fnp-6282	151	17	this	this	DET
fnp-6282	151	18	localization	localization	NOUN
fnp-6282	151	19	enhances	enhance	VERB
fnp-6282	151	20	de	de	X
fnp-6282	151	21	novo	novo	NOUN
fnp-6282	151	22	gtp	gtp	PROPN
fnp-6282	151	23	synthesis	synthesis	NOUN
fnp-6282	152	1	[	[	X
fnp-6282	152	2	2	2	NUM
fnp-6282	152	3	,	,	PUNCT
fnp-6282	152	4	6	6	NUM
fnp-6282	152	5	,	,	PUNCT
fnp-6282	152	6	15	15	NUM
fnp-6282	152	7	,	,	PUNCT
fnp-6282	152	8	33	33	NUM
fnp-6282	152	9	,	,	PUNCT
fnp-6282	152	10	62	62	NUM
fnp-6282	152	11	,	,	PUNCT
fnp-6282	152	12	67	67	NUM
fnp-6282	152	13	]	]	PUNCT
fnp-6282	152	14	.	.	PUNCT
fnp-6282	153	1	this	this	DET
fnp-6282	153	2	model	model	NOUN
fnp-6282	153	3	might	might	AUX
fnp-6282	153	4	explain	explain	VERB
fnp-6282	153	5	the	the	DET
fnp-6282	153	6	common	common	ADJ
fnp-6282	153	7	spatial	spatial	ADJ
fnp-6282	153	8	association	association	NOUN
fnp-6282	153	9	of	of	ADP
fnp-6282	153	10	ncs	ncs	PROPN
fnp-6282	153	11	with	with	ADP
fnp-6282	153	12	the	the	DET
fnp-6282	153	13	nucleolus	nucleolus	NOUN
fnp-6282	153	14	which	which	PRON
fnp-6282	153	15	consumes	consume	VERB
fnp-6282	153	16	a	a	DET
fnp-6282	153	17	vast	vast	ADJ
fnp-6282	153	18	quantity	quantity	NOUN
fnp-6282	153	19	of	of	ADP
fnp-6282	153	20	purine	purine	NOUN
fnp-6282	153	21	nucleotides	nucleotide	NOUN
fnp-6282	153	22	for	for	ADP
fnp-6282	153	23	the	the	DET
fnp-6282	153	24	synthesis	synthesis	NOUN
fnp-6282	153	25	of	of	ADP
fnp-6282	153	26	rrna	rrna	NOUN
fnp-6282	153	27	[	[	X
fnp-6282	153	28	34	34	NUM
fnp-6282	153	29	,	,	PUNCT
fnp-6282	153	30	35	35	NUM
fnp-6282	153	31	]	]	PUNCT
fnp-6282	153	32	.	.	PUNCT
fnp-6282	154	1	by	by	ADP
fnp-6282	154	2	analogy	analogy	NOUN
fnp-6282	154	3	,	,	PUNCT
fnp-6282	154	4	there	there	PRON
fnp-6282	154	5	is	be	VERB
fnp-6282	154	6	evidence	evidence	NOUN
fnp-6282	154	7	that	that	SCONJ
fnp-6282	154	8	acetyl	acetyl	NOUN
fnp-6282	154	9	-	-	PUNCT
fnp-6282	154	10	coa	coa	NOUN
fnp-6282	154	11	,	,	PUNCT
fnp-6282	154	12	essential	essential	ADJ
fnp-6282	154	13	for	for	ADP
fnp-6282	154	14	histone	histone	NOUN
fnp-6282	154	15	acetylation	acetylation	NOUN
fnp-6282	154	16	,	,	PUNCT
fnp-6282	154	17	is	be	AUX
fnp-6282	154	18	synthesized	synthesize	VERB
fnp-6282	154	19	in	in	ADP
fnp-6282	154	20	the	the	DET
fnp-6282	154	21	nucleus	nucleus	NOUN
fnp-6282	154	22	by	by	ADP
fnp-6282	154	23	the	the	DET
fnp-6282	154	24	metabolic	metabolic	PROPN
fnp-6282	154	25	enzymes	enzyme	NOUN
fnp-6282	154	26	atp	atp	PROPN
fnp-6282	154	27	-	-	PUNCT
fnp-6282	154	28	citrate	citrate	NOUN
fnp-6282	154	29	lyase	lyase	NOUN
fnp-6282	154	30	(	(	PUNCT
fnp-6282	154	31	acly	acly	ADJ
fnp-6282	154	32	)	)	PUNCT
fnp-6282	154	33	,	,	PUNCT
fnp-6282	154	34	acyl	acyl	NOUN
fnp-6282	154	35	-	-	PUNCT
fnp-6282	154	36	coa	coa	NOUN
fnp-6282	154	37	synthetase	synthetase	NOUN
fnp-6282	154	38	short	short	ADJ
fnp-6282	154	39	chain	chain	NOUN
fnp-6282	154	40	family	family	NOUN
fnp-6282	154	41	member	member	NOUN
fnp-6282	154	42	2	2	NUM
fnp-6282	154	43	(	(	PUNCT
fnp-6282	154	44	acss2	acss2	X
fnp-6282	154	45	)	)	PUNCT
fnp-6282	154	46	and	and	CCONJ
fnp-6282	154	47	the	the	DET
fnp-6282	154	48	pyruvate	pyruvate	NOUN
fnp-6282	154	49	dehydrogenase	dehydrogenase	NOUN
fnp-6282	154	50	complex	complex	NOUN
fnp-6282	154	51	(	(	PUNCT
fnp-6282	154	52	pdc	pdc	PROPN
fnp-6282	154	53	)	)	PUNCT
fnp-6282	155	1	[	[	X
fnp-6282	155	2	8	8	NUM
fnp-6282	155	3	]	]	PUNCT
fnp-6282	155	4	.	.	PUNCT
fnp-6282	156	1	it	it	PRON
fnp-6282	156	2	has	have	AUX
fnp-6282	156	3	been	be	AUX
fnp-6282	156	4	hypothesized	hypothesize	VERB
fnp-6282	156	5	that	that	SCONJ
fnp-6282	156	6	these	these	DET
fnp-6282	156	7	enzymes	enzyme	NOUN
fnp-6282	156	8	localize	localize	VERB
fnp-6282	156	9	to	to	ADP
fnp-6282	156	10	nuclear	nuclear	ADJ
fnp-6282	156	11	foci	focus	NOUN
fnp-6282	156	12	and	and	CCONJ
fnp-6282	156	13	generate	generate	VERB
fnp-6282	156	14	acetyl	acetyl	NOUN
fnp-6282	156	15	coa	coa	NOUN
fnp-6282	156	16	at	at	ADP
fnp-6282	156	17	sites	site	NOUN
fnp-6282	156	18	of	of	ADP
fnp-6282	156	19	histone	histone	NOUN
fnp-6282	156	20	acetyltransferase	acetyltransferase	ADJ
fnp-6282	156	21	activity	activity	NOUN
fnp-6282	156	22	.	.	PUNCT
fnp-6282	157	1	a	a	DET
fnp-6282	157	2	role	role	NOUN
fnp-6282	157	3	for	for	ADP
fnp-6282	157	4	ncs	ncs	NOUN
fnp-6282	157	5	in	in	ADP
fnp-6282	157	6	the	the	DET
fnp-6282	157	7	generation	generation	NOUN
fnp-6282	157	8	of	of	ADP
fnp-6282	157	9	gtp	gtp	NOUN
fnp-6282	157	10	in	in	ADP
fnp-6282	157	11	the	the	DET
fnp-6282	157	12	nuclear	nuclear	ADJ
fnp-6282	157	13	compartment	compartment	NOUN
fnp-6282	157	14	is	be	AUX
fnp-6282	157	15	predicated	predicate	VERB
fnp-6282	157	16	on	on	ADP
fnp-6282	157	17	the	the	DET
fnp-6282	157	18	local	local	ADJ
fnp-6282	157	19	presence	presence	NOUN
fnp-6282	157	20	of	of	ADP
fnp-6282	157	21	downstream	downstream	ADJ
fnp-6282	157	22	enzymes	enzyme	NOUN
fnp-6282	157	23	in	in	ADP
fnp-6282	157	24	this	this	DET
fnp-6282	157	25	pathway	pathway	NOUN
fnp-6282	157	26	to	to	PART
fnp-6282	157	27	facilitate	facilitate	VERB
fnp-6282	157	28	metabolic	metabolic	NOUN
fnp-6282	157	29	channeling	channeling	NOUN
fnp-6282	157	30	.	.	PUNCT
fnp-6282	158	1	indeed	indeed	ADV
fnp-6282	158	2	,	,	PUNCT
fnp-6282	158	3	gmps	gmp	NOUN
fnp-6282	158	4	,	,	PUNCT
fnp-6282	158	5	which	which	PRON
fnp-6282	158	6	generates	generate	VERB
fnp-6282	158	7	gmp	gmp	PROPN
fnp-6282	158	8	from	from	ADP
fnp-6282	158	9	impdh	impdh	NOUN
fnp-6282	158	10	-	-	PUNCT
fnp-6282	158	11	generated	generate	VERB
fnp-6282	158	12	xmp	xmp	PROPN
fnp-6282	158	13	,	,	PUNCT
fnp-6282	158	14	has	have	AUX
fnp-6282	158	15	been	be	AUX
fnp-6282	158	16	described	describe	VERB
fnp-6282	158	17	in	in	ADP
fnp-6282	158	18	the	the	DET
fnp-6282	158	19	nucleus	nucleus	NOUN
fnp-6282	158	20	[	[	X
fnp-6282	158	21	56	56	NUM
fnp-6282	158	22	]	]	PUNCT
fnp-6282	158	23	.	.	PUNCT
fnp-6282	159	1	alternatively	alternatively	ADV
fnp-6282	159	2	,	,	PUNCT
fnp-6282	159	3	there	there	PRON
fnp-6282	159	4	is	be	VERB
fnp-6282	159	5	increasing	increase	VERB
fnp-6282	159	6	evidence	evidence	NOUN
fnp-6282	159	7	that	that	SCONJ
fnp-6282	159	8	metabolic	metabolic	NOUN
fnp-6282	159	9	enzymes	enzyme	NOUN
fnp-6282	159	10	engage	engage	VERB
fnp-6282	159	11	in	in	ADP
fnp-6282	159	12	moonlighting	moonlight	VERB
fnp-6282	159	13	,	,	PUNCT
fnp-6282	159	14	non	non	ADJ
fnp-6282	159	15	-	-	ADJ
fnp-6282	159	16	enzymatic	enzymatic	ADJ
fnp-6282	159	17	activities	activity	NOUN
fnp-6282	159	18	in	in	ADP
fnp-6282	159	19	the	the	DET
fnp-6282	159	20	nucleus	nucleus	NOUN
fnp-6282	159	21	[	[	X
fnp-6282	159	22	8	8	NUM
fnp-6282	159	23	]	]	PUNCT
fnp-6282	159	24	.	.	PUNCT
fnp-6282	160	1	for	for	ADP
fnp-6282	160	2	example	example	NOUN
fnp-6282	160	3	,	,	PUNCT
fnp-6282	160	4	in	in	ADP
fnp-6282	160	5	saccharomyces	saccharomyce	NOUN
fnp-6282	160	6	cerevesiae	cerevesiae	NOUN
fnp-6282	160	7	,	,	PUNCT
fnp-6282	160	8	the	the	DET
fnp-6282	160	9	nuclear	nuclear	ADJ
fnp-6282	160	10	localization	localization	NOUN
fnp-6282	160	11	of	of	ADP
fnp-6282	160	12	prps	prps	PROPN
fnp-6282	160	13	isoforms	isoform	NOUN
fnp-6282	160	14	has	have	AUX
fnp-6282	160	15	been	be	AUX
fnp-6282	160	16	implicated	implicate	VERB
fnp-6282	160	17	in	in	ADP
fnp-6282	160	18	the	the	DET
fnp-6282	160	19	maintenance	maintenance	NOUN
fnp-6282	160	20	of	of	ADP
fnp-6282	160	21	cell	cell	NOUN
fnp-6282	160	22	wall	wall	NOUN
fnp-6282	160	23	integrity	integrity	PROPN
fnp-6282	160	24	[	[	X
fnp-6282	160	25	57	57	NUM
fnp-6282	160	26	]	]	PUNCT
fnp-6282	160	27	.	.	PUNCT
fnp-6282	161	1	in	in	ADP
fnp-6282	161	2	drosophila	drosophila	PROPN
fnp-6282	161	3	,	,	PUNCT
fnp-6282	161	4	impdh	impdh	NOUN
fnp-6282	161	5	enters	enter	VERB
fnp-6282	161	6	the	the	DET
fnp-6282	161	7	nucleus	nucleus	NOUN
fnp-6282	161	8	in	in	ADP
fnp-6282	161	9	response	response	NOUN
fnp-6282	161	10	to	to	PART
fnp-6282	161	11	oxidative	oxidative	VERB
fnp-6282	161	12	and/or	and/or	CCONJ
fnp-6282	161	13	replicative	replicative	ADJ
fnp-6282	161	14	stress	stress	NOUN
fnp-6282	161	15	,	,	PUNCT
fnp-6282	161	16	binds	bind	VERB
fnp-6282	161	17	single	single	ADV
fnp-6282	161	18	-	-	PUNCT
fnp-6282	161	19	stranded	strand	VERB
fnp-6282	161	20	ct	ct	ADJ
fnp-6282	161	21	-	-	PUNCT
fnp-6282	161	22	rich	rich	ADJ
fnp-6282	161	23	regulatory	regulatory	ADJ
fnp-6282	161	24	dna	dna	NOUN
fnp-6282	161	25	elements	element	NOUN
fnp-6282	161	26	and	and	CCONJ
fnp-6282	161	27	functions	function	NOUN
fnp-6282	161	28	as	as	ADP
fnp-6282	161	29	a	a	DET
fnp-6282	161	30	transcriptional	transcriptional	ADJ
fnp-6282	161	31	repressor	repressor	NOUN
fnp-6282	162	1	[	[	NOUN
fnp-6282	162	2	37	37	NUM
fnp-6282	162	3	]	]	PUNCT
fnp-6282	162	4	.	.	PUNCT
fnp-6282	163	1	in	in	ADP
fnp-6282	163	2	breast	breast	NOUN
fnp-6282	163	3	cancer	cancer	NOUN
fnp-6282	163	4	cells	cell	NOUN
fnp-6282	163	5	,	,	PUNCT
fnp-6282	163	6	chromatin	chromatin	NOUN
fnp-6282	163	7	-	-	PUNCT
fnp-6282	163	8	bound	bind	VERB
fnp-6282	163	9	impdh	impdh	NOUN
fnp-6282	163	10	interacts	interact	VERB
fnp-6282	163	11	with	with	ADP
fnp-6282	163	12	parp1	parp1	NOUN
fnp-6282	163	13	and	and	CCONJ
fnp-6282	163	14	has	have	AUX
fnp-6282	163	15	been	be	AUX
fnp-6282	163	16	implicated	implicate	VERB
fnp-6282	163	17	in	in	ADP
fnp-6282	163	18	dna	dna	PROPN
fnp-6282	163	19	repair	repair	NOUN
fnp-6282	163	20	by	by	ADP
fnp-6282	163	21	regulating	regulate	VERB
fnp-6282	163	22	the	the	DET
fnp-6282	163	23	availability	availability	NOUN
fnp-6282	163	24	of	of	ADP
fnp-6282	163	25	nad+	nad+	PROPN
fnp-6282	164	1	[	[	X
fnp-6282	164	2	20	20	NUM
fnp-6282	164	3	]	]	PUNCT
fnp-6282	164	4	.	.	PUNCT
fnp-6282	165	1	it	it	PRON
fnp-6282	165	2	is	be	AUX
fnp-6282	165	3	tempting	tempting	ADJ
fnp-6282	165	4	to	to	PART
fnp-6282	165	5	speculate	speculate	VERB
fnp-6282	165	6	that	that	SCONJ
fnp-6282	165	7	neurons	neuron	NOUN
fnp-6282	165	8	exploit	exploit	VERB
fnp-6282	165	9	the	the	DET
fnp-6282	165	10	capacity	capacity	NOUN
fnp-6282	165	11	of	of	ADP
fnp-6282	165	12	prps	prps	PROPN
fnp-6282	165	13	and	and	CCONJ
fnp-6282	165	14	impdh	impdh	NOUN
fnp-6282	165	15	to	to	PART
fnp-6282	165	16	form	form	VERB
fnp-6282	165	17	filaments	filament	NOUN
fnp-6282	165	18	as	as	ADP
fnp-6282	165	19	a	a	DET
fnp-6282	165	20	mechanism	mechanism	NOUN
fnp-6282	165	21	to	to	PART
fnp-6282	165	22	regulate	regulate	VERB
fnp-6282	165	23	the	the	DET
fnp-6282	165	24	nucleoplasmic	nucleoplasmic	ADJ
fnp-6282	165	25	availability	availability	NOUN
fnp-6282	165	26	of	of	ADP
fnp-6282	165	27	these	these	DET
fnp-6282	165	28	enzymes	enzyme	NOUN
fnp-6282	165	29	to	to	PART
fnp-6282	165	30	perform	perform	VERB
fnp-6282	165	31	these	these	DET
fnp-6282	165	32	moonlighting	moonlight	VERB
fnp-6282	165	33	functions	function	NOUN
fnp-6282	165	34	.	.	PUNCT
fnp-6282	166	1	according	accord	VERB
fnp-6282	166	2	to	to	ADP
fnp-6282	166	3	the	the	DET
fnp-6282	166	4	beta	beta	NOUN
fnp-6282	166	5	-	-	PUNCT
fnp-6282	166	6	amyloid	amyloid	NOUN
fnp-6282	166	7	hypothesis	hypothesis	NOUN
fnp-6282	166	8	of	of	ADP
fnp-6282	166	9	ad	ad	NOUN
fnp-6282	166	10	pathogenesis	pathogenesis	NOUN
fnp-6282	166	11	,	,	PUNCT
fnp-6282	166	12	the	the	DET
fnp-6282	166	13	natural	natural	ADJ
fnp-6282	166	14	history	history	NOUN
fnp-6282	166	15	of	of	ADP
fnp-6282	166	16	ad	ad	NOUN
fnp-6282	166	17	is	be	AUX
fnp-6282	166	18	characterized	characterize	VERB
fnp-6282	166	19	by	by	ADP
fnp-6282	166	20	a	a	DET
fnp-6282	166	21	protracted	protract	VERB
fnp-6282	166	22	prodromal	prodromal	ADJ
fnp-6282	166	23	period	period	NOUN
fnp-6282	166	24	,	,	PUNCT
fnp-6282	166	25	lasting	last	VERB
fnp-6282	166	26	at	at	ADP
fnp-6282	166	27	least	least	ADJ
fnp-6282	166	28	a	a	PRON
fnp-6282	166	29	decade	decade	NOUN
fnp-6282	166	30	,	,	PUNCT
fnp-6282	166	31	during	during	ADP
fnp-6282	166	32	which	which	PRON
fnp-6282	166	33	beta	beta	NOUN
fnp-6282	166	34	amyloid	amyloid	NOUN
fnp-6282	166	35	accumulates	accumulate	VERB
fnp-6282	166	36	in	in	ADP
fnp-6282	166	37	cortical	cortical	ADJ
fnp-6282	166	38	plaques	plaque	NOUN
fnp-6282	166	39	without	without	ADP
fnp-6282	166	40	overt	overt	ADJ
fnp-6282	166	41	physiological	physiological	ADJ
fnp-6282	166	42	or	or	CCONJ
fnp-6282	166	43	cognitive	cognitive	ADJ
fnp-6282	166	44	sequelae	sequelae	NOUN
fnp-6282	166	45	.	.	PUNCT
fnp-6282	167	1	at	at	ADP
fnp-6282	167	2	some	some	DET
fnp-6282	167	3	point	point	NOUN
fnp-6282	167	4	,	,	PUNCT
fnp-6282	167	5	amyloid	amyloid	NOUN
fnp-6282	167	6	is	be	AUX
fnp-6282	167	7	thought	think	VERB
fnp-6282	167	8	to	to	PART
fnp-6282	167	9	catalyze	catalyze	VERB
fnp-6282	167	10	the	the	DET
fnp-6282	167	11	expansion	expansion	NOUN
fnp-6282	167	12	of	of	ADP
fnp-6282	167	13	neuronal	neuronal	ADJ
fnp-6282	167	14	tau	tau	PROPN
fnp-6282	167	15	pathology	pathology	NOUN
fnp-6282	167	16	from	from	ADP
fnp-6282	167	17	the	the	DET
fnp-6282	167	18	basal	basal	ADJ
fnp-6282	167	19	temporal	temporal	ADJ
fnp-6282	167	20	cortex	cortex	NOUN
fnp-6282	167	21	,	,	PUNCT
fnp-6282	167	22	(	(	PUNCT
fnp-6282	167	23	where	where	SCONJ
fnp-6282	167	24	nfts	nft	NOUN
fnp-6282	167	25	remain	remain	VERB
fnp-6282	167	26	confined	confine	VERB
fnp-6282	167	27	in	in	ADP
fnp-6282	167	28	the	the	DET
fnp-6282	167	29	normal	normal	ADJ
fnp-6282	167	30	elderly	elderly	ADJ
fnp-6282	167	31	)	)	PUNCT
fnp-6282	167	32	,	,	PUNCT
fnp-6282	167	33	to	to	ADP
fnp-6282	167	34	the	the	DET
fnp-6282	167	35	neocortex	neocortex	NOUN
fnp-6282	167	36	,	,	PUNCT
fnp-6282	167	37	and	and	CCONJ
fnp-6282	167	38	trigger	trigger	VERB
fnp-6282	167	39	the	the	DET
fnp-6282	167	40	development	development	NOUN
fnp-6282	167	41	of	of	ADP
fnp-6282	167	42	dementia	dementia	NOUN
fnp-6282	167	43	.	.	PUNCT
fnp-6282	168	1	our	our	PRON
fnp-6282	168	2	study	study	NOUN
fnp-6282	168	3	demonstrates	demonstrate	VERB
fnp-6282	168	4	no	no	DET
fnp-6282	168	5	definite	definite	ADJ
fnp-6282	168	6	relationship	relationship	NOUN
fnp-6282	168	7	between	between	ADP
fnp-6282	168	8	nc	nc	PROPN
fnp-6282	168	9	loss	loss	PROPN
fnp-6282	168	10	and	and	CCONJ
fnp-6282	168	11	beta	beta	NOUN
fnp-6282	168	12	-	-	PUNCT
fnp-6282	168	13	amyloid	amyloid	NOUN
fnp-6282	168	14	load	load	NOUN
fnp-6282	168	15	.	.	PUNCT
fnp-6282	169	1	the	the	DET
fnp-6282	169	2	dissociation	dissociation	NOUN
fnp-6282	169	3	of	of	ADP
fnp-6282	169	4	nc	nc	PROPN
fnp-6282	169	5	loss	loss	PROPN
fnp-6282	169	6	from	from	ADP
fnp-6282	169	7	beta	beta	NOUN
fnp-6282	169	8	amyloid	amyloid	NOUN
fnp-6282	169	9	deposition	deposition	NOUN
fnp-6282	169	10	is	be	AUX
fnp-6282	169	11	consistent	consistent	ADJ
fnp-6282	169	12	with	with	ADP
fnp-6282	169	13	evidence	evidence	NOUN
fnp-6282	169	14	that	that	PRON
fnp-6282	169	15	nucleotide	nucleotide	ADJ
fnp-6282	169	16	dysmetabolism	dysmetabolism	NOUN
fnp-6282	169	17	in	in	ADP
fnp-6282	169	18	the	the	DET
fnp-6282	169	19	ad	ad	NOUN
fnp-6282	169	20	brain	brain	NOUN
fnp-6282	169	21	occurs	occur	VERB
fnp-6282	169	22	independently	independently	ADV
fnp-6282	169	23	of	of	ADP
fnp-6282	169	24	ß	ß	DET
fnp-6282	169	25	-	-	ADJ
fnp-6282	169	26	amyloid	amyloid	ADJ
fnp-6282	169	27	plaques	plaque	NOUN
fnp-6282	169	28	[	[	X
fnp-6282	169	29	1	1	NUM
fnp-6282	169	30	,	,	PUNCT
fnp-6282	169	31	3	3	NUM
fnp-6282	169	32	,	,	PUNCT
fnp-6282	169	33	26	26	NUM
fnp-6282	169	34	,	,	PUNCT
fnp-6282	169	35	29–31	29–31	PROPN
fnp-6282	169	36	]	]	PUNCT
fnp-6282	169	37	.	.	PUNCT
fnp-6282	170	1	on	on	ADP
fnp-6282	170	2	the	the	DET
fnp-6282	170	3	other	other	ADJ
fnp-6282	170	4	hand	hand	NOUN
fnp-6282	170	5	,	,	PUNCT
fnp-6282	170	6	our	our	PRON
fnp-6282	170	7	results	result	NOUN
fnp-6282	170	8	suggest	suggest	VERB
fnp-6282	170	9	that	that	SCONJ
fnp-6282	170	10	nc	nc	PROPN
fnp-6282	170	11	loss	loss	PROPN
fnp-6282	170	12	occurs	occur	VERB
fnp-6282	170	13	subsequent	subsequent	ADJ
fnp-6282	170	14	to	to	ADP
fnp-6282	170	15	beta	beta	NOUN
fnp-6282	170	16	-	-	PUNCT
fnp-6282	170	17	amyloid	amyloid	NOUN
fnp-6282	170	18	deposition	deposition	NOUN
fnp-6282	170	19	,	,	PUNCT
fnp-6282	170	20	and	and	CCONJ
fnp-6282	170	21	,	,	PUNCT
fnp-6282	170	22	based	base	VERB
fnp-6282	170	23	on	on	ADP
fnp-6282	170	24	the	the	DET
fnp-6282	170	25	amyloid	amyloid	NOUN
fnp-6282	170	26	hypothesis	hypothesis	NOUN
fnp-6282	170	27	,	,	PUNCT
fnp-6282	170	28	at	at	ADP
fnp-6282	170	29	the	the	DET
fnp-6282	170	30	stage	stage	NOUN
fnp-6282	170	31	of	of	ADP
fnp-6282	170	32	nft	nft	PROPN
fnp-6282	170	33	expansion	expansion	NOUN
fnp-6282	170	34	.	.	PUNCT
fnp-6282	171	1	this	this	PRON
fnp-6282	171	2	is	be	AUX
fnp-6282	171	3	a	a	DET
fnp-6282	171	4	critical	critical	ADJ
fnp-6282	171	5	phase	phase	NOUN
fnp-6282	171	6	of	of	ADP
fnp-6282	171	7	the	the	DET
fnp-6282	171	8	ad	ad	NOUN
fnp-6282	171	9	pathogenetic	pathogenetic	ADJ
fnp-6282	171	10	cascade	cascade	NOUN
fnp-6282	171	11	as	as	SCONJ
fnp-6282	171	12	nft	nft	PROPN
fnp-6282	171	13	formation	formation	PROPN
fnp-6282	171	14	correlates	correlate	VERB
fnp-6282	171	15	best	well	ADV
fnp-6282	171	16	with	with	ADP
fnp-6282	171	17	cognitive	cognitive	ADJ
fnp-6282	171	18	decline	decline	NOUN
fnp-6282	171	19	.	.	PUNCT
fnp-6282	172	1	notably	notably	ADV
fnp-6282	172	2	,	,	PUNCT
fnp-6282	172	3	despite	despite	SCONJ
fnp-6282	172	4	a	a	DET
fnp-6282	172	5	global	global	ADJ
fnp-6282	172	6	loss	loss	NOUN
fnp-6282	172	7	of	of	ADP
fnp-6282	172	8	ncs	ncs	NOUN
fnp-6282	172	9	from	from	ADP
fnp-6282	172	10	the	the	DET
fnp-6282	172	11	ad	ad	NOUN
fnp-6282	172	12	brain	brain	NOUN
fnp-6282	172	13	,	,	PUNCT
fnp-6282	172	14	our	our	PRON
fnp-6282	172	15	results	result	NOUN
fnp-6282	172	16	indicate	indicate	VERB
fnp-6282	172	17	that	that	SCONJ
fnp-6282	172	18	remaining	remain	VERB
fnp-6282	172	19	ncs	nc	NOUN
fnp-6282	172	20	tend	tend	VERB
fnp-6282	172	21	to	to	PART
fnp-6282	172	22	associate	associate	VERB
fnp-6282	172	23	with	with	ADP
fnp-6282	172	24	nft	nft	PROPN
fnp-6282	172	25	-	-	PUNCT
fnp-6282	172	26	bearing	bear	VERB
fnp-6282	172	27	neurons	neuron	NOUN
fnp-6282	172	28	.	.	PUNCT
fnp-6282	173	1	this	this	DET
fnp-6282	173	2	apparent	apparent	ADJ
fnp-6282	173	3	contradiction	contradiction	NOUN
fnp-6282	173	4	may	may	AUX
fnp-6282	173	5	relate	relate	VERB
fnp-6282	173	6	to	to	ADP
fnp-6282	173	7	the	the	DET
fnp-6282	173	8	fact	fact	NOUN
fnp-6282	173	9	that	that	SCONJ
fnp-6282	173	10	nft	nft	PROPN
fnp-6282	173	11	-	-	PUNCT
fnp-6282	173	12	bearing	bear	VERB
fnp-6282	173	13	neurons	neuron	NOUN
fnp-6282	173	14	comprise	comprise	VERB
fnp-6282	173	15	a	a	DET
fnp-6282	173	16	relatively	relatively	ADV
fnp-6282	173	17	small	small	ADJ
fnp-6282	173	18	proportion	proportion	NOUN
fnp-6282	173	19	of	of	ADP
fnp-6282	173	20	the	the	DET
fnp-6282	173	21	total	total	ADJ
fnp-6282	173	22	neuronal	neuronal	ADJ
fnp-6282	173	23	population	population	NOUN
fnp-6282	173	24	in	in	ADP
fnp-6282	173	25	the	the	DET
fnp-6282	173	26	ad	ad	NOUN
fnp-6282	173	27	cortex	cortex	NOUN
fnp-6282	173	28	(	(	PUNCT
fnp-6282	173	29	1.28	1.28	NUM
fnp-6282	173	30	 	 	SPACE
fnp-6282	173	31	%	%	NOUN
fnp-6282	173	32	in	in	ADP
fnp-6282	173	33	our	our	PRON
fnp-6282	173	34	cohort	cohort	NOUN
fnp-6282	173	35	)	)	PUNCT
fnp-6282	173	36	.	.	PUNCT
fnp-6282	174	1	thus	thus	ADV
fnp-6282	174	2	,	,	PUNCT
fnp-6282	174	3	assuming	assume	VERB
fnp-6282	174	4	that	that	SCONJ
fnp-6282	174	5	nc	nc	PROPN
fnp-6282	174	6	loss	loss	PROPN
fnp-6282	174	7	is	be	AUX
fnp-6282	174	8	independent	independent	ADJ
fnp-6282	174	9	of	of	ADP
fnp-6282	174	10	beta	beta	NOUN
fnp-6282	174	11	-	-	PUNCT
fnp-6282	174	12	amyloid	amyloid	NOUN
fnp-6282	174	13	and	and	CCONJ
fnp-6282	174	14	tau	tau	PROPN
fnp-6282	174	15	deposition	deposition	NOUN
fnp-6282	174	16	,	,	PUNCT
fnp-6282	174	17	the	the	DET
fnp-6282	174	18	net	net	ADJ
fnp-6282	174	19	quantitative	quantitative	ADJ
fnp-6282	174	20	effect	effect	NOUN
fnp-6282	174	21	is	be	AUX
fnp-6282	174	22	a	a	DET
fnp-6282	174	23	global	global	ADJ
fnp-6282	174	24	loss	loss	NOUN
fnp-6282	174	25	of	of	ADP
fnp-6282	174	26	ncs	nc	NOUN
fnp-6282	174	27	,	,	PUNCT
fnp-6282	174	28	despite	despite	SCONJ
fnp-6282	174	29	their	their	PRON
fnp-6282	174	30	preferential	preferential	ADJ
fnp-6282	174	31	localization	localization	NOUN
fnp-6282	174	32	to	to	ADP
fnp-6282	174	33	nft	nft	PROPN
fnp-6282	174	34	-	-	PUNCT
fnp-6282	174	35	bearing	bear	VERB
fnp-6282	174	36	neurons	neuron	NOUN
fnp-6282	174	37	.	.	PUNCT
fnp-6282	175	1	why	why	SCONJ
fnp-6282	175	2	remaining	remain	VERB
fnp-6282	175	3	ncs	nc	NOUN
fnp-6282	175	4	tend	tend	VERB
fnp-6282	175	5	to	to	PART
fnp-6282	175	6	form	form	VERB
fnp-6282	175	7	in	in	ADP
fnp-6282	175	8	nft	nft	PROPN
fnp-6282	175	9	-	-	PUNCT
fnp-6282	175	10	bearing	bear	VERB
fnp-6282	175	11	neurons	neuron	NOUN
fnp-6282	175	12	remains	remain	VERB
fnp-6282	175	13	to	to	PART
fnp-6282	175	14	be	be	AUX
fnp-6282	175	15	explored	explore	VERB
fnp-6282	175	16	.	.	PUNCT
fnp-6282	176	1	it	it	PRON
fnp-6282	176	2	is	be	AUX
fnp-6282	176	3	tempting	tempting	ADJ
fnp-6282	176	4	to	to	PART
fnp-6282	176	5	speculate	speculate	VERB
fnp-6282	176	6	that	that	SCONJ
fnp-6282	176	7	nft	nft	PROPN
fnp-6282	176	8	formation	formation	NOUN
fnp-6282	176	9	imposes	impose	VERB
fnp-6282	176	10	a	a	DET
fnp-6282	176	11	metabolic	metabolic	NOUN
fnp-6282	176	12	burden	burden	NOUN
fnp-6282	176	13	on	on	ADP
fnp-6282	176	14	the	the	DET
fnp-6282	176	15	neuron	neuron	NOUN
fnp-6282	176	16	culminating	culminate	VERB
fnp-6282	176	17	in	in	ADP
fnp-6282	176	18	nc	nc	PROPN
fnp-6282	176	19	formation	formation	NOUN
fnp-6282	176	20	.	.	PUNCT
fnp-6282	177	1	this	this	PRON
fnp-6282	177	2	would	would	AUX
fnp-6282	177	3	be	be	AUX
fnp-6282	177	4	consistent	consistent	ADJ
fnp-6282	177	5	with	with	ADP
fnp-6282	177	6	our	our	PRON
fnp-6282	177	7	previous	previous	ADJ
fnp-6282	177	8	study	study	NOUN
fnp-6282	177	9	demonstrating	demonstrating	NOUN
fnp-6282	177	10	increased	increase	VERB
fnp-6282	177	11	intranuclear	intranuclear	NOUN
fnp-6282	177	12	rods	rod	NOUN
fnp-6282	177	13	in	in	ADP
fnp-6282	177	14	the	the	DET
fnp-6282	177	15	substantia	substantia	NOUN
fnp-6282	177	16	nigra	nigra	NOUN
fnp-6282	177	17	in	in	ADP
fnp-6282	177	18	response	response	NOUN
fnp-6282	177	19	to	to	ADP
fnp-6282	177	20	the	the	DET
fnp-6282	177	21	neurotoxin	neurotoxin	NOUN
fnp-6282	177	22	mptp	mptp	NOUN
fnp-6282	178	1	[	[	X
fnp-6282	178	2	39	39	NUM
fnp-6282	178	3	]	]	PUNCT
fnp-6282	178	4	.	.	PUNCT
fnp-6282	179	1	conversely	conversely	ADV
fnp-6282	179	2	,	,	PUNCT
fnp-6282	179	3	it	it	PRON
fnp-6282	179	4	is	be	AUX
fnp-6282	179	5	possible	possible	ADJ
fnp-6282	179	6	that	that	SCONJ
fnp-6282	179	7	the	the	DET
fnp-6282	179	8	metabolic	metabolic	ADJ
fnp-6282	179	9	status	status	NOUN
fnp-6282	179	10	of	of	ADP
fnp-6282	179	11	the	the	DET
fnp-6282	179	12	neuron	neuron	NOUN
fnp-6282	179	13	which	which	PRON
fnp-6282	179	14	results	result	VERB
fnp-6282	179	15	in	in	ADP
fnp-6282	179	16	nc	nc	PROPN
fnp-6282	179	17	formation	formation	NOUN
fnp-6282	179	18	predisposes	predispose	NOUN
fnp-6282	179	19	neurons	neuron	NOUN
fnp-6282	179	20	to	to	ADP
fnp-6282	179	21	tau	tau	PROPN
fnp-6282	179	22	hyperphosphorylation	hyperphosphorylation	NOUN
fnp-6282	179	23	and	and	CCONJ
fnp-6282	179	24	nft	nft	PROPN
fnp-6282	179	25	pathology	pathology	PROPN
fnp-6282	179	26	.	.	PUNCT
fnp-6282	180	1	elucidating	elucidate	VERB
fnp-6282	180	2	the	the	DET
fnp-6282	180	3	mechanistic	mechanistic	ADJ
fnp-6282	180	4	substrates	substrate	NOUN
fnp-6282	180	5	underlying	underlie	VERB
fnp-6282	180	6	this	this	DET
fnp-6282	180	7	association	association	NOUN
fnp-6282	180	8	may	may	AUX
fnp-6282	180	9	lead	lead	VERB
fnp-6282	180	10	to	to	ADP
fnp-6282	180	11	novel	novel	ADJ
fnp-6282	180	12	pathogenetic	pathogenetic	ADJ
fnp-6282	180	13	concepts	concept	NOUN
fnp-6282	180	14	and	and	CCONJ
fnp-6282	180	15	therapeutic	therapeutic	ADJ
fnp-6282	180	16	targets	target	NOUN
fnp-6282	180	17	.	.	PUNCT
fnp-6282	181	1	our	our	PRON
fnp-6282	181	2	results	result	NOUN
fnp-6282	181	3	may	may	AUX
fnp-6282	181	4	also	also	ADV
fnp-6282	181	5	have	have	VERB
fnp-6282	181	6	disease	disease	NOUN
fnp-6282	181	7	implications	implication	NOUN
fnp-6282	181	8	in	in	ADP
fnp-6282	181	9	a	a	DET
fnp-6282	181	10	broader	broad	ADJ
fnp-6282	181	11	context	context	NOUN
fnp-6282	181	12	.	.	PUNCT
fnp-6282	182	1	for	for	ADP
fnp-6282	182	2	example	example	NOUN
fnp-6282	182	3	,	,	PUNCT
fnp-6282	182	4	ncs	ncs	PROPN
fnp-6282	182	5	were	be	AUX
fnp-6282	182	6	not	not	PART
fnp-6282	182	7	significantly	significantly	ADV
fnp-6282	182	8	reduced	reduce	VERB
fnp-6282	182	9	in	in	ADP
fnp-6282	182	10	frequency	frequency	NOUN
fnp-6282	182	11	in	in	ADP
fnp-6282	182	12	the	the	DET
fnp-6282	182	13	cortex	cortex	NOUN
fnp-6282	182	14	of	of	ADP
fnp-6282	182	15	lbd	lbd	PROPN
fnp-6282	182	16	subjects	subject	NOUN
fnp-6282	182	17	.	.	PUNCT
fnp-6282	183	1	this	this	PRON
fnp-6282	183	2	supports	support	VERB
fnp-6282	183	3	the	the	DET
fnp-6282	183	4	status	status	NOUN
fnp-6282	183	5	of	of	ADP
fnp-6282	183	6	nc	nc	PROPN
fnp-6282	183	7	depletion	depletion	PROPN
fnp-6282	183	8	as	as	ADP
fnp-6282	183	9	a	a	DET
fnp-6282	183	10	disease	disease	NOUN
fnp-6282	183	11	-	-	PUNCT
fnp-6282	183	12	specific	specific	ADJ
fnp-6282	183	13	biomarker	biomarker	NOUN
fnp-6282	183	14	for	for	ADP
fnp-6282	183	15	ad	ad	NOUN
fnp-6282	183	16	as	as	SCONJ
fnp-6282	183	17	opposed	oppose	VERB
fnp-6282	183	18	to	to	ADP
fnp-6282	183	19	lbd	lbd	PROPN
fnp-6282	183	20	.	.	PUNCT
fnp-6282	184	1	in	in	ADP
fnp-6282	184	2	addition	addition	NOUN
fnp-6282	184	3	,	,	PUNCT
fnp-6282	184	4	we	we	PRON
fnp-6282	184	5	have	have	AUX
fnp-6282	184	6	demonstrated	demonstrate	VERB
fnp-6282	184	7	the	the	DET
fnp-6282	184	8	presence	presence	NOUN
fnp-6282	184	9	of	of	ADP
fnp-6282	184	10	inrs	inrs	NOUN
fnp-6282	184	11	in	in	ADP
fnp-6282	184	12	insulin	insulin	NOUN
fnp-6282	184	13	-	-	PUNCT
fnp-6282	184	14	secreting	secrete	VERB
fnp-6282	184	15	pancreatic	pancreatic	ADJ
fnp-6282	184	16	beta	beta	NOUN
fnp-6282	184	17	cells	cell	NOUN
fnp-6282	184	18	[	[	X
fnp-6282	184	19	55	55	NUM
fnp-6282	184	20	]	]	PUNCT
fnp-6282	184	21	.	.	PUNCT
fnp-6282	185	1	like	like	ADP
fnp-6282	185	2	ad	ad	NOUN
fnp-6282	185	3	,	,	PUNCT
fnp-6282	185	4	we	we	PRON
fnp-6282	185	5	have	have	AUX
fnp-6282	185	6	demonstrated	demonstrate	VERB
fnp-6282	185	7	a	a	DET
fnp-6282	185	8	significant	significant	ADJ
fnp-6282	185	9	depletion	depletion	NOUN
fnp-6282	185	10	of	of	ADP
fnp-6282	185	11	inrs	inrs	NOUN
fnp-6282	185	12	from	from	ADP
fnp-6282	185	13	beta	beta	ADJ
fnp-6282	185	14	cells	cell	NOUN
fnp-6282	185	15	in	in	ADP
fnp-6282	185	16	human	human	ADJ
fnp-6282	185	17	type	type	NOUN
fnp-6282	185	18	2	2	NUM
fnp-6282	185	19	diabetes	diabetes	NOUN
fnp-6282	185	20	[	[	X
fnp-6282	185	21	68	68	NUM
fnp-6282	185	22	]	]	PUNCT
fnp-6282	185	23	as	as	ADV
fnp-6282	185	24	well	well	ADV
fnp-6282	185	25	as	as	ADP
fnp-6282	185	26	in	in	ADP
fnp-6282	185	27	animal	animal	NOUN
fnp-6282	185	28	models	model	NOUN
fnp-6282	185	29	of	of	ADP
fnp-6282	185	30	diabetes	diabetes	NOUN
fnp-6282	185	31	[	[	X
fnp-6282	185	32	44	44	NUM
fnp-6282	185	33	]	]	PUNCT
fnp-6282	185	34	.	.	PUNCT
fnp-6282	186	1	this	this	PRON
fnp-6282	186	2	is	be	AUX
fnp-6282	186	3	intriguing	intriguing	ADJ
fnp-6282	186	4	in	in	ADP
fnp-6282	186	5	light	light	NOUN
fnp-6282	186	6	of	of	ADP
fnp-6282	186	7	evidence	evidence	NOUN
fnp-6282	186	8	for	for	ADP
fnp-6282	186	9	:	:	PUNCT
fnp-6282	186	10	1	1	X
fnp-6282	186	11	)	)	PUNCT
fnp-6282	186	12	a	a	DET
fnp-6282	186	13	shared	share	VERB
fnp-6282	186	14	pathogenetic	pathogenetic	ADJ
fnp-6282	186	15	mechanism	mechanism	NOUN
fnp-6282	186	16	underlying	underlie	VERB
fnp-6282	186	17	ad	ad	NOUN
fnp-6282	186	18	and	and	CCONJ
fnp-6282	186	19	type	type	NOUN
fnp-6282	186	20	2	2	NUM
fnp-6282	186	21	diabetes	diabetes	NOUN
fnp-6282	186	22	[	[	X
fnp-6282	186	23	46	46	NUM
fnp-6282	186	24	]	]	PUNCT
fnp-6282	186	25	and	and	CCONJ
fnp-6282	186	26	2	2	X
fnp-6282	186	27	)	)	PUNCT
fnp-6282	186	28	an	an	DET
fnp-6282	186	29	important	important	ADJ
fnp-6282	186	30	role	role	NOUN
fnp-6282	186	31	for	for	ADP
fnp-6282	186	32	purine	purine	NOUN
fnp-6282	186	33	nucleotide	nucleotide	ADJ
fnp-6282	186	34	metabolism	metabolism	NOUN
fnp-6282	186	35	in	in	ADP
fnp-6282	186	36	beta	beta	ADJ
fnp-6282	186	37	cell	cell	NOUN
fnp-6282	186	38	function	function	NOUN
fnp-6282	186	39	and	and	CCONJ
fnp-6282	186	40	survival	survival	NOUN
fnp-6282	186	41	and	and	CCONJ
fnp-6282	186	42	in	in	ADP
fnp-6282	186	43	diabetes	diabetes	NOUN
fnp-6282	186	44	[	[	X
fnp-6282	186	45	43	43	NUM
fnp-6282	186	46	]	]	PUNCT
fnp-6282	186	47	.	.	PUNCT
fnp-6282	187	1	moreover	moreover	ADV
fnp-6282	187	2	,	,	PUNCT
fnp-6282	187	3	we	we	PRON
fnp-6282	187	4	have	have	AUX
fnp-6282	187	5	demonstrated	demonstrate	VERB
fnp-6282	187	6	evidence	evidence	NOUN
fnp-6282	187	7	for	for	ADP
fnp-6282	187	8	an	an	DET
fnp-6282	187	9	inverse	inverse	NOUN
fnp-6282	187	10	correlation	correlation	NOUN
fnp-6282	187	11	between	between	ADP
fnp-6282	187	12	cellular	cellular	ADJ
fnp-6282	187	13	secretory	secretory	ADJ
fnp-6282	187	14	activity	activity	NOUN
fnp-6282	187	15	and	and	CCONJ
fnp-6282	187	16	inr	inr	NOUN
fnp-6282	187	17	formation	formation	NOUN
fnp-6282	187	18	[	[	X
fnp-6282	187	19	63	63	NUM
fnp-6282	187	20	]	]	PUNCT
fnp-6282	187	21	.	.	PUNCT
fnp-6282	188	1	notably	notably	ADV
fnp-6282	188	2	,	,	PUNCT
fnp-6282	188	3	beta	beta	NOUN
fnp-6282	188	4	-	-	PUNCT
fnp-6282	188	5	cell	cell	NOUN
fnp-6282	188	6	and	and	CCONJ
fnp-6282	188	7	neuronal	neuronal	ADJ
fnp-6282	188	8	hyperactivity	hyperactivity	NOUN
fnp-6282	188	9	are	be	AUX
fnp-6282	188	10	hallmarks	hallmark	NOUN
fnp-6282	188	11	of	of	ADP
fnp-6282	188	12	diabetes	diabetes	NOUN
fnp-6282	188	13	and	and	CCONJ
fnp-6282	188	14	ad	ad	NOUN
fnp-6282	189	1	[	[	X
fnp-6282	189	2	10	10	NUM
fnp-6282	189	3	]	]	PUNCT
fnp-6282	189	4	,	,	PUNCT
fnp-6282	189	5	providing	provide	VERB
fnp-6282	189	6	an	an	DET
fnp-6282	189	7	additional	additional	ADJ
fnp-6282	189	8	,	,	PUNCT
fnp-6282	189	9	or	or	CCONJ
fnp-6282	189	10	alternative	alternative	ADJ
fnp-6282	189	11	unifying	unify	VERB
fnp-6282	189	12	explanation	explanation	NOUN
fnp-6282	189	13	for	for	ADP
fnp-6282	189	14	nc	nc	PROPN
fnp-6282	189	15	depletion	depletion	NOUN
fnp-6282	189	16	in	in	ADP
fnp-6282	189	17	the	the	DET
fnp-6282	189	18	two	two	NUM
fnp-6282	189	19	diseases	disease	NOUN
fnp-6282	189	20	.	.	PUNCT
fnp-6282	190	1	nc	nc	PROPN
fnp-6282	190	2	depletion	depletion	PROPN
fnp-6282	190	3	may	may	AUX
fnp-6282	190	4	represent	represent	VERB
fnp-6282	190	5	a	a	DET
fnp-6282	190	6	morphological	morphological	ADJ
fnp-6282	190	7	signpost	signpost	NOUN
fnp-6282	190	8	indicating	indicate	VERB
fnp-6282	190	9	a	a	DET
fnp-6282	190	10	common	common	ADJ
fnp-6282	190	11	metabolic	metabolic	NOUN
fnp-6282	190	12	substrate	substrate	NOUN
fnp-6282	190	13	contributing	contribute	VERB
fnp-6282	190	14	to	to	ADP
fnp-6282	190	15	the	the	DET
fnp-6282	190	16	pathogenesis	pathogenesis	NOUN
fnp-6282	190	17	of	of	ADP
fnp-6282	190	18	these	these	DET
fnp-6282	190	19	two	two	NUM
fnp-6282	190	20	related	related	ADJ
fnp-6282	190	21	disorders	disorder	NOUN
fnp-6282	190	22	of	of	ADP
fnp-6282	190	23	ageing	ageing	NOUN
fnp-6282	190	24	.	.	PUNCT
fnp-6282	191	1	our	our	PRON
fnp-6282	191	2	study	study	NOUN
fnp-6282	191	3	has	have	VERB
fnp-6282	191	4	some	some	DET
fnp-6282	191	5	limitations	limitation	NOUN
fnp-6282	191	6	.	.	PUNCT
fnp-6282	192	1	participant	participant	ADJ
fnp-6282	192	2	recruitment	recruitment	NOUN
fnp-6282	192	3	was	be	AUX
fnp-6282	192	4	based	base	VERB
fnp-6282	192	5	on	on	ADP
fnp-6282	192	6	retrospective	retrospective	ADJ
fnp-6282	192	7	review	review	NOUN
fnp-6282	192	8	of	of	ADP
fnp-6282	192	9	neuropathology	neuropathology	NOUN
fnp-6282	192	10	reports	report	VERB
fnp-6282	192	11	.	.	PUNCT
fnp-6282	193	1	a	a	DET
fnp-6282	193	2	small	small	ADJ
fnp-6282	193	3	proportion	proportion	NOUN
fnp-6282	193	4	of	of	ADP
fnp-6282	193	5	the	the	DET
fnp-6282	193	6	ad	ad	NOUN
fnp-6282	193	7	cases	case	NOUN
fnp-6282	193	8	were	be	AUX
fnp-6282	193	9	diagnosed	diagnose	VERB
fnp-6282	193	10	prior	prior	ADV
fnp-6282	193	11	to	to	ADP
fnp-6282	193	12	the	the	DET
fnp-6282	193	13	currently	currently	ADV
fnp-6282	193	14	recommended	recommend	VERB
fnp-6282	193	15	diagnostic	diagnostic	ADJ
fnp-6282	193	16	criteria	criterion	NOUN
fnp-6282	193	17	[	[	X
fnp-6282	193	18	47	47	NUM
fnp-6282	193	19	]	]	PUNCT
fnp-6282	193	20	,	,	PUNCT
fnp-6282	193	21	precluding	preclude	VERB
fnp-6282	193	22	assignment	assignment	NOUN
fnp-6282	193	23	of	of	ADP
fnp-6282	193	24	an	an	DET
fnp-6282	193	25	"	"	PUNCT
fnp-6282	193	26	abc	abc	PROPN
fnp-6282	193	27	"	"	PUNCT
fnp-6282	193	28	score	score	NOUN
fnp-6282	193	29	.	.	PUNCT
fnp-6282	194	1	only	only	ADJ
fnp-6282	194	2	cases	case	NOUN
fnp-6282	194	3	with	with	ADP
fnp-6282	194	4	"	"	PUNCT
fnp-6282	194	5	severe	severe	ADJ
fnp-6282	194	6	"	"	PUNCT
fnp-6282	194	7	adnc	adnc	ADJ
fnp-6282	194	8	or	or	CCONJ
fnp-6282	194	9	a	a	DET
fnp-6282	194	10	braak	braak	NOUN
fnp-6282	194	11	score	score	NOUN
fnp-6282	194	12	of	of	ADP
fnp-6282	194	13	v	v	NUM
fnp-6282	194	14	or	or	CCONJ
fnp-6282	194	15	vi	vi	PROPN
fnp-6282	194	16	were	be	AUX
fnp-6282	194	17	included	include	VERB
fnp-6282	194	18	in	in	ADP
fnp-6282	194	19	the	the	DET
fnp-6282	194	20	ad	ad	NOUN
fnp-6282	194	21	cohort	cohort	NOUN
fnp-6282	194	22	.	.	PUNCT
fnp-6282	195	1	the	the	DET
fnp-6282	195	2	objective	objective	NOUN
fnp-6282	195	3	of	of	ADP
fnp-6282	195	4	this	this	DET
fnp-6282	195	5	study	study	NOUN
fnp-6282	195	6	was	be	AUX
fnp-6282	195	7	to	to	PART
fnp-6282	195	8	confirm	confirm	VERB
fnp-6282	195	9	our	our	PRON
fnp-6282	195	10	previous	previous	ADJ
fnp-6282	195	11	findings	finding	NOUN
fnp-6282	195	12	in	in	ADP
fnp-6282	195	13	the	the	DET
fnp-6282	195	14	context	context	NOUN
fnp-6282	195	15	of	of	ADP
fnp-6282	195	16	new	new	ADJ
fnp-6282	195	17	knowledge	knowledge	NOUN
fnp-6282	195	18	regarding	regard	VERB
fnp-6282	195	19	the	the	DET
fnp-6282	195	20	possible	possible	ADJ
fnp-6282	195	21	functional	functional	ADJ
fnp-6282	195	22	significance	significance	NOUN
fnp-6282	195	23	of	of	ADP
fnp-6282	195	24	,	,	PUNCT
fnp-6282	195	25	and	and	CCONJ
fnp-6282	195	26	novel	novel	ADJ
fnp-6282	195	27	marker	marker	NOUN
fnp-6282	195	28	for	for	ADP
fnp-6282	195	29	,	,	PUNCT
fnp-6282	195	30	these	these	DET
fnp-6282	195	31	intranuclear	intranuclear	NOUN
fnp-6282	195	32	structures	structure	NOUN
fnp-6282	195	33	.	.	PUNCT
fnp-6282	196	1	consequently	consequently	ADV
fnp-6282	196	2	,	,	PUNCT
fnp-6282	196	3	the	the	DET
fnp-6282	196	4	comparison	comparison	NOUN
fnp-6282	196	5	of	of	ADP
fnp-6282	196	6	subjects	subject	NOUN
fnp-6282	196	7	with	with	ADP
fnp-6282	196	8	only	only	ADV
fnp-6282	196	9	"	"	PUNCT
fnp-6282	196	10	high	high	ADJ
fnp-6282	196	11	"	"	PUNCT
fnp-6282	196	12	adnc	adnc	ADJ
fnp-6282	196	13	with	with	ADP
fnp-6282	196	14	controls	control	NOUN
fnp-6282	196	15	is	be	AUX
fnp-6282	196	16	dichotomous	dichotomous	ADJ
fnp-6282	196	17	.	.	PUNCT
fnp-6282	197	1	future	future	ADJ
fnp-6282	197	2	studies	study	NOUN
fnp-6282	197	3	will	will	AUX
fnp-6282	197	4	provide	provide	VERB
fnp-6282	197	5	a	a	DET
fnp-6282	197	6	more	more	ADV
fnp-6282	197	7	granular	granular	ADJ
fnp-6282	197	8	understanding	understanding	NOUN
fnp-6282	197	9	of	of	ADP
fnp-6282	197	10	the	the	DET
fnp-6282	197	11	role	role	NOUN
fnp-6282	197	12	of	of	ADP
fnp-6282	197	13	ncs	ncs	NOUN
fnp-6282	197	14	in	in	ADP
fnp-6282	197	15	the	the	DET
fnp-6282	197	16	ad	ad	NOUN
fnp-6282	197	17	pathogenic	pathogenic	ADJ
fnp-6282	197	18	cascade	cascade	NOUN
fnp-6282	197	19	by	by	ADP
fnp-6282	197	20	analyzing	analyze	VERB
fnp-6282	197	21	their	their	PRON
fnp-6282	197	22	status	status	NOUN
fnp-6282	197	23	at	at	ADP
fnp-6282	197	24	"	"	PUNCT
fnp-6282	197	25	low	low	ADJ
fnp-6282	197	26	"	"	PUNCT
fnp-6282	197	27	and	and	CCONJ
fnp-6282	197	28	"	"	PUNCT
fnp-6282	197	29	intermediate	intermediate	ADJ
fnp-6282	197	30	"	"	PUNCT
fnp-6282	197	31	adnc	adnc	ADJ
fnp-6282	197	32	stages	stage	NOUN
fnp-6282	197	33	.	.	PUNCT
fnp-6282	198	1	this	this	PRON
fnp-6282	198	2	is	be	AUX
fnp-6282	198	3	being	be	AUX
fnp-6282	198	4	pursued	pursue	VERB
fnp-6282	198	5	in	in	ADP
fnp-6282	198	6	mouse	mouse	NOUN
fnp-6282	198	7	studies	study	NOUN
fnp-6282	198	8	as	as	ADV
fnp-6282	198	9	well	well	ADV
fnp-6282	198	10	.	.	PUNCT
fnp-6282	199	1	there	there	PRON
fnp-6282	199	2	is	be	VERB
fnp-6282	199	3	increasing	increase	VERB
fnp-6282	199	4	recognition	recognition	NOUN
fnp-6282	199	5	that	that	PRON
fnp-6282	199	6	tdp-43	tdp-43	VERB
fnp-6282	199	7	proteinopathy	proteinopathy	ADJ
fnp-6282	199	8	in	in	ADP
fnp-6282	199	9	the	the	DET
fnp-6282	199	10	form	form	NOUN
fnp-6282	199	11	of	of	ADP
fnp-6282	199	12	limbic	limbic	ADJ
fnp-6282	199	13	-	-	PUNCT
fnp-6282	199	14	predominant	predominant	ADJ
fnp-6282	199	15	age	age	NOUN
fnp-6282	199	16	-	-	PUNCT
fnp-6282	199	17	related	relate	VERB
fnp-6282	199	18	tdp-43	tdp-43	NOUN
fnp-6282	199	19	encephalopathy	encephalopathy	ADJ
fnp-6282	199	20	(	(	PUNCT
fnp-6282	199	21	late	late	ADJ
fnp-6282	199	22	)	)	PUNCT
fnp-6282	199	23	is	be	AUX
fnp-6282	199	24	a	a	DET
fnp-6282	199	25	common	common	ADJ
fnp-6282	199	26	co	co	NOUN
fnp-6282	199	27	-	-	NOUN
fnp-6282	199	28	pathology	pathology	NOUN
fnp-6282	199	29	in	in	ADP
fnp-6282	199	30	adnc	adnc	ADJ
fnp-6282	199	31	.	.	PUNCT
fnp-6282	200	1	we	we	PRON
fnp-6282	200	2	did	do	AUX
fnp-6282	200	3	not	not	PART
fnp-6282	200	4	examine	examine	VERB
fnp-6282	200	5	the	the	DET
fnp-6282	200	6	impact	impact	NOUN
fnp-6282	200	7	of	of	ADP
fnp-6282	200	8	this	this	DET
fnp-6282	200	9	co	co	NOUN
fnp-6282	200	10	-	-	NOUN
fnp-6282	200	11	pathology	pathology	NOUN
fnp-6282	200	12	on	on	ADP
fnp-6282	200	13	nc	nc	PROPN
fnp-6282	200	14	status	status	NOUN
fnp-6282	200	15	in	in	ADP
fnp-6282	200	16	the	the	DET
fnp-6282	200	17	present	present	ADJ
fnp-6282	200	18	study	study	NOUN
fnp-6282	200	19	.	.	PUNCT
fnp-6282	201	1	n	n	DET
fnp-6282	201	2	summary	summary	NOUN
fnp-6282	201	3	,	,	PUNCT
fnp-6282	201	4	we	we	PRON
fnp-6282	201	5	have	have	AUX
fnp-6282	201	6	demonstrated	demonstrate	VERB
fnp-6282	201	7	:	:	PUNCT
fnp-6282	201	8	1	1	X
fnp-6282	201	9	)	)	PUNCT
fnp-6282	201	10	that	that	PRON
fnp-6282	201	11	neuronal	neuronal	ADJ
fnp-6282	201	12	prps	prps	PROPN
fnp-6282	201	13	ncs	ncs	PROPN
fnp-6282	201	14	are	be	AUX
fnp-6282	201	15	reduced	reduce	VERB
fnp-6282	201	16	in	in	ADP
fnp-6282	201	17	frequency	frequency	NOUN
fnp-6282	201	18	in	in	ADP
fnp-6282	201	19	the	the	DET
fnp-6282	201	20	ad	ad	NOUN
fnp-6282	201	21	temporal	temporal	ADJ
fnp-6282	201	22	cortex	cortex	NOUN
fnp-6282	201	23	and	and	CCONJ
fnp-6282	201	24	2	2	NUM
fnp-6282	201	25	)	)	PUNCT
fnp-6282	201	26	that	that	SCONJ
fnp-6282	201	27	remaining	remain	VERB
fnp-6282	201	28	ncs	ncs	NOUN
fnp-6282	201	29	show	show	VERB
fnp-6282	201	30	an	an	DET
fnp-6282	201	31	association	association	NOUN
fnp-6282	201	32	with	with	ADP
fnp-6282	201	33	nft	nft	PROPN
fnp-6282	201	34	-	-	PUNCT
fnp-6282	201	35	containing	contain	VERB
fnp-6282	201	36	neurons	neuron	NOUN
fnp-6282	201	37	(	(	PUNCT
fnp-6282	201	38	fig	fig	NOUN
fnp-6282	201	39	.	.	PUNCT
fnp-6282	201	40	 	 	SPACE
fnp-6282	201	41	4	4	NUM
fnp-6282	201	42	)	)	PUNCT
fnp-6282	201	43	.	.	PUNCT
fnp-6282	202	1	the	the	DET
fnp-6282	202	2	results	result	NOUN
fnp-6282	202	3	of	of	ADP
fnp-6282	202	4	this	this	DET
fnp-6282	202	5	study	study	NOUN
fnp-6282	202	6	provide	provide	VERB
fnp-6282	202	7	an	an	DET
fnp-6282	202	8	unexplored	unexplored	ADJ
fnp-6282	202	9	avenue	avenue	NOUN
fnp-6282	202	10	for	for	ADP
fnp-6282	202	11	investigation	investigation	NOUN
fnp-6282	202	12	with	with	ADP
fnp-6282	202	13	respect	respect	NOUN
fnp-6282	202	14	to	to	ADP
fnp-6282	202	15	ad	ad	NOUN
fnp-6282	202	16	pathogenesis	pathogenesis	NOUN
fnp-6282	202	17	.	.	PUNCT
fnp-6282	203	1	the	the	DET
fnp-6282	203	2	potential	potential	ADJ
fnp-6282	203	3	involvement	involvement	NOUN
fnp-6282	203	4	of	of	ADP
fnp-6282	203	5	prps	prps	PROPN
fnp-6282	203	6	ncs	ncs	PROPN
fnp-6282	203	7	in	in	ADP
fnp-6282	203	8	the	the	DET
fnp-6282	203	9	cellular	cellular	ADJ
fnp-6282	203	10	mechanisms	mechanism	NOUN
fnp-6282	203	11	underlying	underlie	VERB
fnp-6282	203	12	ad	ad	NOUN
fnp-6282	203	13	-	-	PUNCT
fnp-6282	203	14	associated	associate	VERB
fnp-6282	203	15	neurodegeneration	neurodegeneration	NOUN
fnp-6282	203	16	is	be	AUX
fnp-6282	203	17	consistent	consistent	ADJ
fnp-6282	203	18	with	with	ADP
fnp-6282	203	19	evidence	evidence	NOUN
fnp-6282	203	20	for	for	ADP
fnp-6282	203	21	metabolic	metabolic	ADJ
fnp-6282	203	22	dysfunction	dysfunction	NOUN
fnp-6282	203	23	in	in	ADP
fnp-6282	203	24	ad	ad	NOUN
fnp-6282	203	25	.	.	PUNCT
fnp-6282	204	1	future	future	ADJ
fnp-6282	204	2	mechanistic	mechanistic	ADJ
fnp-6282	204	3	studies	study	NOUN
fnp-6282	204	4	addressing	address	VERB
fnp-6282	204	5	the	the	DET
fnp-6282	204	6	functional	functional	ADJ
fnp-6282	204	7	significance	significance	NOUN
fnp-6282	204	8	of	of	ADP
fnp-6282	204	9	prps	prps	PROPN
fnp-6282	204	10	ncs	ncs	PROPN
fnp-6282	204	11	will	will	AUX
fnp-6282	204	12	elucidate	elucidate	VERB
fnp-6282	204	13	their	their	PRON
fnp-6282	204	14	role	role	NOUN
fnp-6282	204	15	in	in	ADP
fnp-6282	204	16	healthy	healthy	ADJ
fnp-6282	204	17	neurons	neuron	NOUN
fnp-6282	204	18	and	and	CCONJ
fnp-6282	204	19	in	in	ADP
fnp-6282	204	20	disease	disease	NOUN
fnp-6282	204	21	.	.	PUNCT
fnp-6282	205	1	if	if	SCONJ
fnp-6282	205	2	these	these	PRON
fnp-6282	205	3	confirm	confirm	VERB
fnp-6282	205	4	that	that	PRON
fnp-6282	205	5	intranuclear	intranuclear	NOUN
fnp-6282	205	6	filamentation	filamentation	NOUN
fnp-6282	205	7	of	of	ADP
fnp-6282	205	8	these	these	DET
fnp-6282	205	9	metabolic	metabolic	NOUN
fnp-6282	205	10	enzymes	enzyme	NOUN
fnp-6282	205	11	plays	play	VERB
fnp-6282	205	12	a	a	DET
fnp-6282	205	13	role	role	NOUN
fnp-6282	205	14	in	in	ADP
fnp-6282	205	15	neuronal	neuronal	ADJ
fnp-6282	205	16	health	health	NOUN
fnp-6282	205	17	and	and	CCONJ
fnp-6282	205	18	metabolism	metabolism	NOUN
fnp-6282	205	19	,	,	PUNCT
fnp-6282	205	20	as	as	SCONJ
fnp-6282	205	21	has	have	AUX
fnp-6282	205	22	been	be	AUX
fnp-6282	205	23	suggested	suggest	VERB
fnp-6282	205	24	,	,	PUNCT
fnp-6282	205	25	its	its	PRON
fnp-6282	205	26	failure	failure	NOUN
fnp-6282	205	27	in	in	ADP
fnp-6282	205	28	ad	ad	NOUN
fnp-6282	205	29	may	may	AUX
fnp-6282	205	30	provide	provide	VERB
fnp-6282	205	31	a	a	DET
fnp-6282	205	32	novel	novel	NOUN
fnp-6282	205	33	,	,	PUNCT
fnp-6282	205	34	biologically	biologically	ADV
fnp-6282	205	35	rational	rational	ADJ
fnp-6282	205	36	therapeutic	therapeutic	ADJ
fnp-6282	205	37	target	target	NOUN
fnp-6282	205	38	.	.	PUNCT
fnp-6282	206	1	fig	fig	NOUN
fnp-6282	206	2	.	.	PUNCT
fnp-6282	206	3	 	 	SPACE
fnp-6282	207	1	4	4	NUM
fnp-6282	207	2	schematic	schematic	ADJ
fnp-6282	207	3	summary	summary	NOUN
fnp-6282	207	4	of	of	ADP
fnp-6282	207	5	the	the	DET
fnp-6282	207	6	results	result	NOUN
fnp-6282	207	7	of	of	ADP
fnp-6282	207	8	the	the	DET
fnp-6282	207	9	present	present	ADJ
fnp-6282	207	10	study	study	NOUN
fnp-6282	207	11	.	.	PUNCT
fnp-6282	208	1	neuronal	neuronal	ADJ
fnp-6282	208	2	ncs	ncs	NOUN
fnp-6282	208	3	(	(	PUNCT
fnp-6282	208	4	green	green	ADJ
fnp-6282	208	5	)	)	PUNCT
fnp-6282	208	6	are	be	AUX
fnp-6282	208	7	reduced	reduce	VERB
fnp-6282	208	8	in	in	ADP
fnp-6282	208	9	frequency	frequency	NOUN
fnp-6282	208	10	in	in	ADP
fnp-6282	208	11	the	the	DET
fnp-6282	208	12	brains	brain	NOUN
fnp-6282	208	13	of	of	ADP
fnp-6282	208	14	ad	ad	NOUN
fnp-6282	208	15	participants	participant	NOUN
fnp-6282	208	16	.	.	PUNCT
fnp-6282	209	1	remaining	remain	VERB
fnp-6282	209	2	ncs	nc	NOUN
fnp-6282	209	3	are	be	AUX
fnp-6282	209	4	relatively	relatively	ADV
fnp-6282	209	5	more	more	ADV
fnp-6282	209	6	frequent	frequent	ADJ
fnp-6282	209	7	in	in	ADP
fnp-6282	209	8	nft	nft	PROPN
fnp-6282	209	9	(	(	PUNCT
fnp-6282	209	10	red)-bearing	red)-beare	VERB
fnp-6282	209	11	neurons	neuron	NOUN
fnp-6282	209	12	.	.	PUNCT
fnp-6282	210	1	declarations	declaration	NOUN
fnp-6282	210	2	author	author	NOUN
fnp-6282	210	3	contributions	contribution	NOUN
fnp-6282	210	4	conceptualization	conceptualization	NOUN
fnp-6282	210	5	:	:	PUNCT
fnp-6282	210	6	john	john	PROPN
fnp-6282	210	7	woulfe	woulfe	PROPN
fnp-6282	210	8	,	,	PUNCT
fnp-6282	210	9	david	david	PROPN
fnp-6282	210	10	munoz	munoz	PROPN
fnp-6282	210	11	;	;	PUNCT
fnp-6282	210	12	methodology	methodology	NOUN
fnp-6282	210	13	:	:	PUNCT
fnp-6282	210	14	john	john	PROPN
fnp-6282	210	15	woulfe	woulfe	PROPN
fnp-6282	210	16	,	,	PUNCT
fnp-6282	210	17	alyona	alyona	PROPN
fnp-6282	210	18	ivanova	ivanova	PROPN
fnp-6282	210	19	;	;	PUNCT
fnp-6282	210	20	formal	formal	ADJ
fnp-6282	210	21	analysis	analysis	NOUN
fnp-6282	210	22	and	and	CCONJ
fnp-6282	210	23	investigation	investigation	NOUN
fnp-6282	210	24	:	:	PUNCT
fnp-6282	211	1	john	john	PROPN
fnp-6282	211	2	woulfe	woulfe	PROPN
fnp-6282	211	3	,	,	PUNCT
fnp-6282	211	4	alyona	alyona	PROPN
fnp-6282	211	5	ivanova	ivanova	PROPN
fnp-6282	211	6	;	;	PUNCT
fnp-6282	211	7	writing	write	VERB
fnp-6282	211	8	-	-	PUNCT
fnp-6282	211	9	original	original	ADJ
fnp-6282	211	10	draft	draft	NOUN
fnp-6282	211	11	preparation	preparation	NOUN
fnp-6282	211	12	:	:	PUNCT
fnp-6282	211	13	john	john	PROPN
fnp-6282	211	14	woulfe	woulfe	PROPN
fnp-6282	211	15	;	;	PUNCT
fnp-6282	211	16	writing	write	VERB
fnp-6282	211	17	-	-	PUNCT
fnp-6282	211	18	review	review	NOUN
fnp-6282	211	19	and	and	CCONJ
fnp-6282	211	20	editing	editing	NOUN
fnp-6282	211	21	:	:	PUNCT
fnp-6282	211	22	david	david	PROPN
fnp-6282	211	23	munoz	munoz	PROPN
fnp-6282	211	24	,	,	PUNCT
fnp-6282	211	25	alyona	alyona	PROPN
fnp-6282	211	26	ivanova	ivanova	PROPN
fnp-6282	211	27	;	;	PUNCT
fnp-6282	211	28	resources	resource	NOUN
fnp-6282	211	29	:	:	PUNCT
fnp-6282	211	30	john	john	PROPN
fnp-6282	211	31	woulfe	woulfe	PROPN
fnp-6282	211	32	,	,	PUNCT
fnp-6282	211	33	david	david	PROPN
fnp-6282	211	34	munoz	munoz	PROPN
fnp-6282	211	35	;	;	PUNCT
fnp-6282	211	36	supervision	supervision	NOUN
fnp-6282	211	37	:	:	PUNCT
fnp-6282	211	38	john	john	PROPN
fnp-6282	211	39	woulfe	woulfe	PROPN
fnp-6282	211	40	,	,	PUNCT
fnp-6282	211	41	david	david	PROPN
fnp-6282	211	42	munoz	munoz	PROPN
fnp-6282	211	43	.	.	PUNCT
fnp-6282	212	1	funding	funding	NOUN
fnp-6282	212	2	statement	statement	NOUN
fnp-6282	212	3	no	no	DET
fnp-6282	212	4	funding	funding	NOUN
fnp-6282	212	5	was	be	AUX
fnp-6282	212	6	received	receive	VERB
fnp-6282	212	7	for	for	ADP
fnp-6282	212	8	conducting	conduct	VERB
fnp-6282	212	9	this	this	DET
fnp-6282	212	10	study	study	NOUN
fnp-6282	212	11	.	.	PUNCT
fnp-6282	213	1	conflict	conflict	NOUN
fnp-6282	213	2	of	of	ADP
fnp-6282	213	3	interest	interest	NOUN
fnp-6282	213	4	statement	statement	NOUN
fnp-6282	213	5	the	the	DET
fnp-6282	213	6	authors	author	NOUN
fnp-6282	213	7	have	have	VERB
fnp-6282	213	8	no	no	DET
fnp-6282	213	9	relevant	relevant	ADJ
fnp-6282	213	10	financial	financial	ADJ
fnp-6282	213	11	or	or	CCONJ
fnp-6282	213	12	non	non	ADJ
fnp-6282	213	13	-	-	ADJ
fnp-6282	213	14	financial	financial	ADJ
fnp-6282	213	15	interests	interest	NOUN
fnp-6282	213	16	to	to	PART
fnp-6282	213	17	disclose	disclose	VERB
fnp-6282	213	18	.	.	PUNCT
fnp-6282	214	1	ethics	ethic	NOUN
fnp-6282	214	2	approval	approval	VERB
fnp-6282	214	3	this	this	DET
fnp-6282	214	4	retrospective	retrospective	ADJ
fnp-6282	214	5	post	post	ADJ
fnp-6282	214	6	-	-	ADJ
fnp-6282	214	7	mortem	mortem	ADJ
fnp-6282	214	8	study	study	NOUN
fnp-6282	214	9	was	be	AUX
fnp-6282	214	10	conducted	conduct	VERB
fnp-6282	214	11	in	in	ADP
fnp-6282	214	12	accordance	accordance	NOUN
fnp-6282	214	13	with	with	ADP
fnp-6282	214	14	the	the	DET
fnp-6282	214	15	ethical	ethical	ADJ
fnp-6282	214	16	standards	standard	NOUN
fnp-6282	214	17	of	of	ADP
fnp-6282	214	18	the	the	DET
fnp-6282	214	19	ottawa	ottawa	PROPN
fnp-6282	214	20	hospital	hospital	PROPN
fnp-6282	214	21	.	.	PUNCT
fnp-6282	215	1	data	datum	NOUN
fnp-6282	215	2	availability	availability	NOUN
fnp-6282	215	3	the	the	DET
fnp-6282	215	4	data	data	NOUN
fnp-6282	215	5	is	be	AUX
fnp-6282	215	6	available	available	ADJ
fnp-6282	215	7	from	from	ADP
fnp-6282	215	8	the	the	DET
fnp-6282	215	9	corresponding	corresponding	ADJ
fnp-6282	215	10	author	author	NOUN
fnp-6282	215	11	upon	upon	SCONJ
fnp-6282	215	12	reasonable	reasonable	ADJ
fnp-6282	215	13	request	request	NOUN
fnp-6282	215	14	.	.	PUNCT
fnp-6282	216	1	raw	raw	ADJ
fnp-6282	216	2	data	datum	NOUN
fnp-6282	216	3	is	be	AUX
fnp-6282	216	4	available	available	ADJ
fnp-6282	216	5	in	in	ADP
fnp-6282	216	6	supplementary	supplementary	ADJ
fnp-6282	216	7	table	table	NOUN
fnp-6282	216	8	 	 	SPACE
fnp-6282	216	9	1	1	NUM
fnp-6282	216	10	.	.	PUNCT
fnp-6282	217	1	acknowledgements	acknowledgement	NOUN
fnp-6282	217	2	the	the	DET
fnp-6282	217	3	authors	author	NOUN
fnp-6282	217	4	would	would	AUX
fnp-6282	217	5	like	like	VERB
fnp-6282	217	6	to	to	PART
fnp-6282	217	7	acknowledge	acknowledge	VERB
fnp-6282	217	8	the	the	DET
fnp-6282	217	9	excellent	excellent	ADJ
fnp-6282	217	10	assistance	assistance	NOUN
fnp-6282	217	11	of	of	ADP
fnp-6282	217	12	dr	dr	PROPN
fnp-6282	217	13	.	.	PROPN
fnp-6282	217	14	sharlene	sharlene	PROPN
fnp-6282	217	15	faulkes	faulkes	PROPN
fnp-6282	217	16	,	,	PUNCT
fnp-6282	217	17	marjan	marjan	PROPN
fnp-6282	217	18	khalili	khalili	PROPN
fnp-6282	217	19	mahani	mahani	PROPN
fnp-6282	217	20	,	,	PUNCT
fnp-6282	217	21	and	and	CCONJ
fnp-6282	217	22	zaida	zaida	PROPN
fnp-6282	217	23	ticas	ticas	PROPN
fnp-6282	217	24	and	and	CCONJ
fnp-6282	217	25	the	the	DET
fnp-6282	217	26	louise	louise	PROPN
fnp-6282	217	27	pelletier	pelletier	PROPN
fnp-6282	217	28	histology	histology	NOUN
fnp-6282	217	29	core	core	NOUN
fnp-6282	217	30	facility	facility	NOUN
fnp-6282	217	31	(	(	PUNCT
fnp-6282	217	32	rrid	rrid	NOUN
fnp-6282	217	33	:	:	PUNCT
fnp-6282	217	34	scr_021737	scr_021737	NUM
fnp-6282	217	35	)	)	PUNCT
fnp-6282	217	36	,	,	PUNCT
fnp-6282	217	37	department	department	NOUN
fnp-6282	217	38	of	of	ADP
fnp-6282	217	39	pathology	pathology	PROPN
fnp-6282	217	40	and	and	CCONJ
fnp-6282	217	41	laboratory	laboratory	NOUN
fnp-6282	217	42	medicine	medicine	NOUN
fnp-6282	217	43	,	,	PUNCT
fnp-6282	217	44	university	university	NOUN
fnp-6282	217	45	of	of	ADP
fnp-6282	217	46	ottawa	ottawa	PROPN
fnp-6282	217	47	.	.	PUNCT
fnp-6282	218	1	references	reference	NOUN
fnp-6282	218	2	1	1	NUM
fnp-6282	218	3	.	.	PUNCT
fnp-6282	219	1	alonso	alonso	PROPN
fnp-6282	219	2	-	-	PUNCT
fnp-6282	219	3	andres	andres	PROPN
fnp-6282	219	4	p	p	NOUN
fnp-6282	219	5	,	,	PUNCT
fnp-6282	219	6	albasanz	albasanz	PROPN
fnp-6282	219	7	jl	jl	PROPN
fnp-6282	219	8	,	,	PUNCT
fnp-6282	219	9	ferrer	ferrer	PROPN
fnp-6282	219	10	i	i	PROPN
fnp-6282	219	11	,	,	PUNCT
fnp-6282	219	12	martin	martin	PROPN
fnp-6282	219	13	m	m	PROPN
fnp-6282	219	14	(	(	PUNCT
fnp-6282	219	15	2018	2018	NUM
fnp-6282	219	16	)	)	PUNCT
fnp-6282	219	17	purine	purine	NOUN
fnp-6282	219	18	-	-	PUNCT
fnp-6282	219	19	related	relate	VERB
fnp-6282	219	20	metabolites	metabolite	NOUN
fnp-6282	219	21	and	and	CCONJ
fnp-6282	219	22	their	their	PRON
fnp-6282	219	23	converting	convert	VERB
fnp-6282	219	24	enzymes	enzyme	NOUN
fnp-6282	219	25	are	be	AUX
fnp-6282	219	26	altered	alter	VERB
fnp-6282	219	27	in	in	ADP
fnp-6282	219	28	frontal	frontal	ADJ
fnp-6282	219	29	,	,	PUNCT
fnp-6282	219	30	parietal	parietal	ADJ
fnp-6282	219	31	and	and	CCONJ
fnp-6282	219	32	temporal	temporal	ADJ
fnp-6282	219	33	cortex	cortex	NOUN
fnp-6282	219	34	at	at	ADP
fnp-6282	219	35	early	early	ADJ
fnp-6282	219	36	stages	stage	NOUN
fnp-6282	219	37	of	of	ADP
fnp-6282	219	38	alzheimer	alzheimer	PROPN
fnp-6282	219	39	's	's	PART
fnp-6282	219	40	disease	disease	NOUN
fnp-6282	219	41	pathology	pathology	NOUN
fnp-6282	219	42	.	.	PUNCT
fnp-6282	220	1	brain	brain	NOUN
fnp-6282	220	2	pathol	pathol	NOUN
fnp-6282	220	3	28	28	NUM
fnp-6282	220	4	:	:	PUNCT
fnp-6282	220	5	933	933	NUM
fnp-6282	220	6	-	-	SYM
fnp-6282	220	7	946	946	NUM
fnp-6282	220	8	.	.	PUNCT
fnp-6282	221	1	https://doi.org/10.1111/bpa.12592	https://doi.org/10.1111/bpa.12592	NOUN
fnp-6282	221	2	2	2	NUM
fnp-6282	221	3	.	.	PUNCT
fnp-6282	221	4	an	an	DET
fnp-6282	221	5	s	s	PROPN
fnp-6282	221	6	,	,	PUNCT
fnp-6282	221	7	kumar	kumar	PROPN
fnp-6282	221	8	r	r	PROPN
fnp-6282	221	9	,	,	PUNCT
fnp-6282	221	10	sheets	sheet	NOUN
fnp-6282	221	11	ed	ed	NOUN
fnp-6282	221	12	,	,	PUNCT
fnp-6282	221	13	benkovic	benkovic	ADJ
fnp-6282	221	14	sj	sj	PROPN
fnp-6282	221	15	(	(	PUNCT
fnp-6282	221	16	2008	2008	NUM
fnp-6282	221	17	)	)	PUNCT
fnp-6282	221	18	reversible	reversible	ADJ
fnp-6282	221	19	compartmentalization	compartmentalization	NOUN
fnp-6282	221	20	of	of	ADP
fnp-6282	221	21	de	de	X
fnp-6282	221	22	novo	novo	NOUN
fnp-6282	221	23	purine	purine	NOUN
fnp-6282	221	24	biosynthetic	biosynthetic	ADJ
fnp-6282	221	25	complexes	complex	NOUN
fnp-6282	221	26	in	in	ADP
fnp-6282	221	27	living	living	NOUN
fnp-6282	221	28	cells	cell	NOUN
fnp-6282	221	29	.	.	PUNCT
fnp-6282	222	1	science	science	NOUN
fnp-6282	222	2	320	320	NUM
fnp-6282	222	3	:	:	PUNCT
fnp-6282	222	4	103	103	NUM
fnp-6282	222	5	-	-	SYM
fnp-6282	222	6	106	106	NUM
fnp-6282	222	7	.	.	PUNCT
fnp-6282	223	1	https://doi.org/10.1126/science.1152241	https://doi.org/10.1126/science.1152241	X
fnp-6282	223	2	3	3	X
fnp-6282	223	3	.	.	PUNCT
fnp-6282	223	4	ansoleaga	ansoleaga	PROPN
fnp-6282	223	5	b	b	PROPN
fnp-6282	223	6	,	,	PUNCT
fnp-6282	223	7	jove	jove	PROPN
fnp-6282	223	8	m	m	PROPN
fnp-6282	223	9	,	,	PUNCT
fnp-6282	223	10	schluter	schluter	PROPN
fnp-6282	223	11	a	a	PROPN
fnp-6282	223	12	,	,	PUNCT
fnp-6282	223	13	garcia	garcia	PROPN
fnp-6282	223	14	-	-	PUNCT
fnp-6282	223	15	esparcia	esparcia	PROPN
fnp-6282	223	16	p	p	NOUN
fnp-6282	223	17	,	,	PUNCT
fnp-6282	223	18	moreno	moreno	PROPN
fnp-6282	223	19	j	j	PROPN
fnp-6282	223	20	,	,	PUNCT
fnp-6282	223	21	pujol	pujol	NOUN
fnp-6282	223	22	a	a	NOUN
fnp-6282	223	23	,	,	PUNCT
fnp-6282	223	24	pamplona	pamplona	PROPN
fnp-6282	223	25	r	r	NOUN
fnp-6282	223	26	,	,	PUNCT
fnp-6282	223	27	portero	portero	PROPN
fnp-6282	223	28	-	-	PUNCT
fnp-6282	223	29	otin	otin	PROPN
fnp-6282	223	30	m	m	PROPN
fnp-6282	223	31	,	,	PUNCT
fnp-6282	223	32	ferrer	ferrer	PROPN
fnp-6282	223	33	i	i	PROPN
fnp-6282	223	34	(	(	PUNCT
fnp-6282	223	35	2015	2015	NUM
fnp-6282	223	36	)	)	PUNCT
fnp-6282	223	37	deregulation	deregulation	NOUN
fnp-6282	223	38	of	of	ADP
fnp-6282	223	39	purine	purine	NOUN
fnp-6282	223	40	metabolism	metabolism	NOUN
fnp-6282	223	41	in	in	ADP
fnp-6282	223	42	alzheimer	alzheimer	PROPN
fnp-6282	223	43	's	's	PART
fnp-6282	223	44	disease	disease	NOUN
fnp-6282	223	45	.	.	PUNCT
fnp-6282	224	1	neurobiol	neurobiol	PROPN
fnp-6282	224	2	aging	age	VERB
fnp-6282	224	3	36	36	NUM
fnp-6282	224	4	:	:	SYM
fnp-6282	224	5	68	68	NUM
fnp-6282	224	6	-	-	SYM
fnp-6282	224	7	80	80	NUM
fnp-6282	224	8	.	.	PUNCT
fnp-6282	225	1	https://doi.org/10.1016/j.neurobiolaging.2014.08.004	https://doi.org/10.1016/j.neurobiolaging.2014.08.004	PROPN
fnp-6282	225	2	4	4	NUM
fnp-6282	225	3	.	.	PUNCT
fnp-6282	225	4	attems	attems	PROPN
fnp-6282	225	5	j	j	PROPN
fnp-6282	225	6	,	,	PUNCT
fnp-6282	225	7	toledo	toledo	PROPN
fnp-6282	225	8	jb	jb	PROPN
fnp-6282	225	9	,	,	PUNCT
fnp-6282	225	10	walker	walker	PROPN
fnp-6282	225	11	l	l	PROPN
fnp-6282	225	12	,	,	PUNCT
fnp-6282	225	13	gelpi	gelpi	NOUN
fnp-6282	225	14	e	e	NOUN
fnp-6282	225	15	,	,	PUNCT
fnp-6282	225	16	gentleman	gentleman	NOUN
fnp-6282	225	17	s	s	PROPN
fnp-6282	225	18	,	,	PUNCT
fnp-6282	225	19	halliday	halliday	PROPN
fnp-6282	225	20	g	g	PROPN
fnp-6282	225	21	,	,	PUNCT
fnp-6282	225	22	hortobagyi	hortobagyi	PROPN
fnp-6282	225	23	t	t	PROPN
fnp-6282	225	24	,	,	PUNCT
fnp-6282	225	25	jellinger	jellinger	PROPN
fnp-6282	225	26	k	k	PROPN
fnp-6282	225	27	,	,	PUNCT
fnp-6282	225	28	kovacs	kovacs	PROPN
fnp-6282	225	29	gg	gg	PROPN
fnp-6282	225	30	,	,	PUNCT
fnp-6282	225	31	lee	lee	PROPN
fnp-6282	225	32	ebet	ebet	PROPN
fnp-6282	225	33	al	al	PROPN
fnp-6282	225	34	(	(	PUNCT
fnp-6282	225	35	2021	2021	NUM
fnp-6282	225	36	)	)	PUNCT
fnp-6282	225	37	neuropathological	neuropathological	ADJ
fnp-6282	225	38	consensus	consensus	NOUN
fnp-6282	225	39	criteria	criterion	NOUN
fnp-6282	225	40	for	for	ADP
fnp-6282	225	41	the	the	DET
fnp-6282	225	42	evaluation	evaluation	NOUN
fnp-6282	225	43	of	of	ADP
fnp-6282	225	44	lewy	lewy	PROPN
fnp-6282	225	45	pathology	pathology	PROPN
fnp-6282	225	46	in	in	ADP
fnp-6282	225	47	post	post	ADJ
fnp-6282	225	48	-	-	ADJ
fnp-6282	225	49	mortem	mortem	ADJ
fnp-6282	225	50	brains	brain	NOUN
fnp-6282	225	51	:	:	PUNCT
fnp-6282	225	52	a	a	DET
fnp-6282	225	53	multi	multi	ADJ
fnp-6282	225	54	-	-	ADJ
fnp-6282	225	55	centre	centre	ADJ
fnp-6282	225	56	study	study	NOUN
fnp-6282	225	57	.	.	PUNCT
fnp-6282	226	1	acta	acta	PROPN
fnp-6282	226	2	neuropathol	neuropathol	PROPN
fnp-6282	226	3	141	141	NUM
fnp-6282	226	4	:	:	PUNCT
fnp-6282	226	5	159	159	NUM
fnp-6282	226	6	-	-	SYM
fnp-6282	226	7	172	172	NUM
fnp-6282	226	8	.	.	PUNCT
fnp-6282	227	1	https://doi.org/10.1007/s00401-020-02255-2	https://doi.org/10.1007/s00401-020-02255-2	NUM
fnp-6282	227	2	5	5	NUM
fnp-6282	227	3	.	.	PUNCT
fnp-6282	227	4	aughey	aughey	PROPN
fnp-6282	227	5	gn	gn	PROPN
fnp-6282	227	6	,	,	PUNCT
fnp-6282	227	7	liu	liu	PROPN
fnp-6282	227	8	jl	jl	PROPN
fnp-6282	227	9	(	(	PUNCT
fnp-6282	227	10	2015	2015	NUM
fnp-6282	227	11	)	)	PUNCT
fnp-6282	227	12	metabolic	metabolic	NOUN
fnp-6282	227	13	regulation	regulation	NOUN
fnp-6282	227	14	via	via	ADP
fnp-6282	227	15	enzyme	enzyme	NOUN
fnp-6282	227	16	filamentation	filamentation	NOUN
fnp-6282	227	17	.	.	PUNCT
fnp-6282	228	1	crit	crit	PROPN
fnp-6282	228	2	rev	rev	PROPN
fnp-6282	228	3	biochem	biochem	PROPN
fnp-6282	228	4	mol	mol	ADP
fnp-6282	228	5	biol	biol	PROPN
fnp-6282	228	6	51	51	NUM
fnp-6282	228	7	:	:	SYM
fnp-6282	228	8	282	282	NUM
fnp-6282	228	9	-	-	SYM
fnp-6282	228	10	293	293	NUM
fnp-6282	228	11	.	.	PUNCT
fnp-6282	229	1	https://doi.org/10.3109/10409238.2016.1172555	https://doi.org/10.3109/10409238.2016.1172555	NOUN
fnp-6282	229	2	6	6	NUM
fnp-6282	229	3	.	.	PUNCT
fnp-6282	230	1	bianchi	bianchi	PROPN
fnp-6282	230	2	g	g	PROPN
fnp-6282	230	3	,	,	PUNCT
fnp-6282	230	4	longhi	longhi	PROPN
fnp-6282	230	5	s	s	PROPN
fnp-6282	230	6	,	,	PUNCT
fnp-6282	230	7	grandori	grandori	ADJ
fnp-6282	230	8	r	r	NOUN
fnp-6282	230	9	,	,	PUNCT
fnp-6282	230	10	brocca	brocca	VERB
fnp-6282	230	11	s	s	PROPN
fnp-6282	230	12	(	(	PUNCT
fnp-6282	230	13	2020	2020	NUM
fnp-6282	230	14	)	)	PUNCT
fnp-6282	230	15	relevance	relevance	NOUN
fnp-6282	230	16	of	of	ADP
fnp-6282	230	17	electrostatic	electrostatic	ADJ
fnp-6282	230	18	charges	charge	NOUN
fnp-6282	230	19	in	in	ADP
fnp-6282	230	20	compactness	compactness	NOUN
fnp-6282	230	21	,	,	PUNCT
fnp-6282	230	22	aggregation	aggregation	NOUN
fnp-6282	230	23	,	,	PUNCT
fnp-6282	230	24	and	and	CCONJ
fnp-6282	230	25	phase	phase	NOUN
fnp-6282	230	26	separation	separation	NOUN
fnp-6282	230	27	of	of	ADP
fnp-6282	230	28	intrinsically	intrinsically	ADV
fnp-6282	230	29	disordered	disordered	ADJ
fnp-6282	230	30	proteins	protein	NOUN
fnp-6282	230	31	.	.	PUNCT
fnp-6282	231	1	int	int	PROPN
fnp-6282	231	2	j	j	PROPN
fnp-6282	231	3	mol	mol	ADP
fnp-6282	231	4	sci	sci	PROPN
fnp-6282	231	5	21	21	NUM
fnp-6282	231	6	:	:	PUNCT
fnp-6282	231	7	.	.	PUNCT
fnp-6282	232	1	https://doi.org/10.3390/ijms21176208	https://doi.org/10.3390/ijms21176208	PROPN
fnp-6282	232	2	7	7	NUM
fnp-6282	232	3	.	.	PUNCT
fnp-6282	232	4	boon	boon	PROPN
fnp-6282	232	5	r	r	PROPN
fnp-6282	232	6	,	,	PUNCT
fnp-6282	232	7	silveira	silveira	PROPN
fnp-6282	232	8	gg	gg	PROPN
fnp-6282	232	9	,	,	PUNCT
fnp-6282	232	10	mostoslavsky	mostoslavsky	ADJ
fnp-6282	232	11	r	r	NOUN
fnp-6282	232	12	(	(	PUNCT
fnp-6282	232	13	2020	2020	NUM
fnp-6282	232	14	)	)	PUNCT
fnp-6282	232	15	nuclear	nuclear	ADJ
fnp-6282	232	16	metabolism	metabolism	NOUN
fnp-6282	232	17	and	and	CCONJ
fnp-6282	232	18	the	the	DET
fnp-6282	232	19	regulation	regulation	NOUN
fnp-6282	232	20	of	of	ADP
fnp-6282	232	21	the	the	DET
fnp-6282	232	22	epigenome	epigenome	NOUN
fnp-6282	232	23	.	.	PUNCT
fnp-6282	233	1	nat	nat	PROPN
fnp-6282	233	2	metab	metab	PROPN
fnp-6282	233	3	2	2	NUM
fnp-6282	233	4	:	:	SYM
fnp-6282	233	5	1190	1190	NUM
fnp-6282	233	6	-	-	SYM
fnp-6282	233	7	1203	1203	NUM
fnp-6282	233	8	.	.	PUNCT
fnp-6282	234	1	https://doi.org/10.1038/s42255-020-00285-4	https://doi.org/10.1038/s42255-020-00285-4	NUM
fnp-6282	234	2	8	8	NUM
fnp-6282	234	3	.	.	PUNCT
fnp-6282	234	4	boukouris	boukouris	PROPN
fnp-6282	234	5	ae	ae	PROPN
fnp-6282	234	6	,	,	PUNCT
fnp-6282	234	7	zervopoulos	zervopoulos	PROPN
fnp-6282	234	8	sd	sd	PROPN
fnp-6282	234	9	,	,	PUNCT
fnp-6282	234	10	michelakis	michelakis	PROPN
fnp-6282	234	11	ed	ed	PROPN
fnp-6282	234	12	(	(	PUNCT
fnp-6282	234	13	2016	2016	NUM
fnp-6282	234	14	)	)	PUNCT
fnp-6282	234	15	metabolic	metabolic	NOUN
fnp-6282	234	16	enzymes	enzyme	NOUN
fnp-6282	234	17	moonlighting	moonlight	VERB
fnp-6282	234	18	in	in	ADP
fnp-6282	234	19	the	the	DET
fnp-6282	234	20	nucleus	nucleus	NOUN
fnp-6282	234	21	:	:	PUNCT
fnp-6282	234	22	metabolic	metabolic	ADJ
fnp-6282	234	23	regulation	regulation	NOUN
fnp-6282	234	24	of	of	ADP
fnp-6282	234	25	gene	gene	NOUN
fnp-6282	234	26	transcription	transcription	NOUN
fnp-6282	234	27	.	.	PUNCT
fnp-6282	235	1	trends	trend	NOUN
fnp-6282	235	2	biochem	biochem	PROPN
fnp-6282	235	3	sci	sci	PROPN
fnp-6282	235	4	41	41	NUM
fnp-6282	235	5	:	:	PUNCT
fnp-6282	235	6	712	712	NUM
fnp-6282	235	7	-	-	SYM
fnp-6282	235	8	730	730	NUM
fnp-6282	235	9	.	.	PUNCT
fnp-6282	236	1	https://doi.org/10.1016/j.tibs.2016.05.013	https://doi.org/10.1016/j.tibs.2016.05.013	NOUN
fnp-6282	236	2	9	9	NUM
fnp-6282	236	3	.	.	PUNCT
fnp-6282	237	1	braak	braak	PROPN
fnp-6282	237	2	h	h	PROPN
fnp-6282	237	3	,	,	PUNCT
fnp-6282	237	4	alafuzoff	alafuzoff	NOUN
fnp-6282	238	1	i	i	PRON
fnp-6282	238	2	,	,	PUNCT
fnp-6282	238	3	arzberger	arzberger	PROPN
fnp-6282	238	4	t	t	PROPN
fnp-6282	238	5	,	,	PUNCT
fnp-6282	238	6	kretzschmar	kretzschmar	PROPN
fnp-6282	238	7	h	h	PROPN
fnp-6282	238	8	,	,	PUNCT
fnp-6282	238	9	del	del	PROPN
fnp-6282	238	10	tredici	tredici	PROPN
fnp-6282	238	11	k	k	PROPN
fnp-6282	238	12	(	(	PUNCT
fnp-6282	238	13	2006	2006	NUM
fnp-6282	238	14	)	)	PUNCT
fnp-6282	238	15	staging	staging	NOUN
fnp-6282	238	16	of	of	ADP
fnp-6282	238	17	alzheimer	alzheimer	PROPN
fnp-6282	238	18	disease	disease	NOUN
fnp-6282	238	19	-	-	PUNCT
fnp-6282	238	20	associated	associate	VERB
fnp-6282	238	21	neurofibrillary	neurofibrillary	ADJ
fnp-6282	238	22	pathology	pathology	NOUN
fnp-6282	238	23	using	use	VERB
fnp-6282	238	24	paraffin	paraffin	NOUN
fnp-6282	238	25	sections	section	NOUN
fnp-6282	238	26	and	and	CCONJ
fnp-6282	238	27	immunocytochemistry	immunocytochemistry	NOUN
fnp-6282	238	28	.	.	PUNCT
fnp-6282	239	1	acta	acta	PROPN
fnp-6282	239	2	neuropathol	neuropathol	PROPN
fnp-6282	239	3	112	112	NUM
fnp-6282	239	4	:	:	PUNCT
fnp-6282	239	5	389	389	NUM
fnp-6282	239	6	-	-	SYM
fnp-6282	239	7	404	404	NUM
fnp-6282	239	8	.	.	PUNCT
fnp-6282	240	1	https://doi.org/10.1007/s00401-006-0127-z	https://doi.org/10.1007/s00401-006-0127-z	PROPN
fnp-6282	240	2	10	10	NUM
fnp-6282	240	3	.	.	PUNCT
fnp-6282	241	1	busche	busche	PROPN
fnp-6282	241	2	ma	ma	PROPN
fnp-6282	241	3	,	,	PUNCT
fnp-6282	241	4	konnerth	konnerth	VERB
fnp-6282	241	5	a	a	DET
fnp-6282	241	6	(	(	PUNCT
fnp-6282	241	7	2015	2015	NUM
fnp-6282	241	8	)	)	PUNCT
fnp-6282	241	9	neuronal	neuronal	ADJ
fnp-6282	241	10	hyperactivity	hyperactivity	NOUN
fnp-6282	241	11	--	--	PUNCT
fnp-6282	241	12	a	a	DET
fnp-6282	241	13	key	key	ADJ
fnp-6282	241	14	defect	defect	NOUN
fnp-6282	241	15	in	in	ADP
fnp-6282	241	16	alzheimer	alzheimer	PROPN
fnp-6282	241	17	's	's	PART
fnp-6282	241	18	disease	disease	NOUN
fnp-6282	241	19	?	?	PUNCT
fnp-6282	242	1	bioessays	bioessay	VERB
fnp-6282	242	2	37	37	NUM
fnp-6282	242	3	:	:	SYM
fnp-6282	242	4	624	624	NUM
fnp-6282	242	5	-	-	SYM
fnp-6282	242	6	632	632	NUM
fnp-6282	242	7	.	.	PUNCT
fnp-6282	242	8	https://doi.org/10.1002/bies.201500004	https://doi.org/10.1002/bies.201500004	VERB
fnp-6282	242	9	11	11	NUM
fnp-6282	242	10	.	.	PUNCT
fnp-6282	243	1	calise	calise	NOUN
fnp-6282	243	2	sj	sj	PROPN
fnp-6282	243	3	,	,	PUNCT
fnp-6282	243	4	bizzaro	bizzaro	PROPN
fnp-6282	243	5	n	n	PROPN
fnp-6282	243	6	,	,	PUNCT
fnp-6282	243	7	nguyen	nguyen	PROPN
fnp-6282	243	8	t	t	PROPN
fnp-6282	243	9	,	,	PUNCT
fnp-6282	243	10	bassetti	bassetti	NOUN
fnp-6282	243	11	d	d	PROPN
fnp-6282	243	12	,	,	PUNCT
fnp-6282	243	13	porcelli	porcelli	PROPN
fnp-6282	243	14	b	b	PROPN
fnp-6282	243	15	,	,	PUNCT
fnp-6282	243	16	almi	almi	NOUN
fnp-6282	243	17	p	p	NOUN
fnp-6282	243	18	,	,	PUNCT
fnp-6282	243	19	barberio	barberio	NOUN
fnp-6282	243	20	g	g	NOUN
fnp-6282	243	21	,	,	PUNCT
fnp-6282	243	22	pesce	pesce	NOUN
fnp-6282	243	23	g	g	NOUN
fnp-6282	243	24	,	,	PUNCT
fnp-6282	243	25	satoh	satoh	NOUN
fnp-6282	243	26	m	m	PROPN
fnp-6282	243	27	,	,	PUNCT
fnp-6282	243	28	chan	chan	PROPN
fnp-6282	243	29	ek	ek	PROPN
fnp-6282	243	30	(	(	PUNCT
fnp-6282	243	31	2016	2016	NUM
fnp-6282	243	32	)	)	PUNCT
fnp-6282	243	33	anti	anti	NOUN
fnp-6282	243	34	-	-	ADJ
fnp-6282	243	35	rods	rod	NOUN
fnp-6282	243	36	/	/	SYM
fnp-6282	243	37	rings	ring	NOUN
fnp-6282	243	38	autoantibody	autoantibody	NOUN
fnp-6282	243	39	seropositivity	seropositivity	NOUN
fnp-6282	243	40	does	do	AUX
fnp-6282	243	41	not	not	PART
fnp-6282	243	42	affect	affect	VERB
fnp-6282	243	43	response	response	NOUN
fnp-6282	243	44	to	to	ADP
fnp-6282	243	45	telaprevir	telaprevir	PROPN
fnp-6282	243	46	treatment	treatment	VERB
fnp-6282	243	47	for	for	ADP
fnp-6282	243	48	chronic	chronic	ADJ
fnp-6282	243	49	hepatitis	hepatitis	NOUN
fnp-6282	243	50	c	c	NOUN
fnp-6282	243	51	infection	infection	NOUN
fnp-6282	243	52	.	.	PUNCT
fnp-6282	244	1	auto	auto	NOUN
fnp-6282	244	2	immun	immun	PROPN
fnp-6282	244	3	highlights	highlight	NOUN
fnp-6282	244	4	7	7	NUM
fnp-6282	244	5	:	:	SYM
fnp-6282	244	6	15	15	NUM
fnp-6282	244	7	.	.	PUNCT
fnp-6282	244	8	https://doi.org/10.1007/s13317-016-0087-9	https://doi.org/10.1007/s13317-016-0087-9	NOUN
fnp-6282	244	9	12	12	NUM
fnp-6282	244	10	.	.	PUNCT
fnp-6282	245	1	calise	calise	NOUN
fnp-6282	245	2	sj	sj	PROPN
fnp-6282	245	3	,	,	PUNCT
fnp-6282	245	4	chan	chan	PROPN
fnp-6282	245	5	ekl	ekl	PROPN
fnp-6282	245	6	(	(	PUNCT
fnp-6282	245	7	2020	2020	NUM
fnp-6282	245	8	)	)	PUNCT
fnp-6282	245	9	anti	anti	NOUN
fnp-6282	245	10	-	-	ADJ
fnp-6282	245	11	rods	rod	NOUN
fnp-6282	245	12	/	/	SYM
fnp-6282	245	13	rings	ring	NOUN
fnp-6282	245	14	autoantibody	autoantibody	NOUN
fnp-6282	245	15	and	and	CCONJ
fnp-6282	245	16	impdh	impdh	NOUN
fnp-6282	245	17	filaments	filament	NOUN
fnp-6282	245	18	:	:	PUNCT
fnp-6282	245	19	an	an	DET
fnp-6282	245	20	update	update	NOUN
fnp-6282	245	21	after	after	ADP
fnp-6282	245	22	fifteen	fifteen	NUM
fnp-6282	245	23	years	year	NOUN
fnp-6282	245	24	of	of	ADP
fnp-6282	245	25	discovery	discovery	NOUN
fnp-6282	245	26	.	.	PUNCT
fnp-6282	246	1	autoimmun	autoimmun	PROPN
fnp-6282	246	2	rev	rev	VERB
fnp-6282	246	3	19	19	NUM
fnp-6282	246	4	:	:	SYM
fnp-6282	246	5	102643	102643	NUM
fnp-6282	246	6	.	.	PUNCT
fnp-6282	247	1	https://doi.org/10.1016/j.autrev.2020.102643	https://doi.org/10.1016/j.autrev.2020.102643	NOUN
fnp-6282	247	2	13	13	NUM
fnp-6282	247	3	.	.	PUNCT
fnp-6282	248	1	carlier	carlier	NOUN
fnp-6282	248	2	mf	mf	X
fnp-6282	248	3	(	(	PUNCT
fnp-6282	248	4	1982	1982	NUM
fnp-6282	248	5	)	)	PUNCT
fnp-6282	248	6	guanosine-5'-triphosphate	guanosine-5'-triphosphate	NOUN
fnp-6282	248	7	hydrolysis	hydrolysis	NOUN
fnp-6282	248	8	and	and	CCONJ
fnp-6282	248	9	tubulin	tubulin	NOUN
fnp-6282	248	10	polymerization	polymerization	NOUN
fnp-6282	248	11	.	.	PUNCT
fnp-6282	249	1	review	review	NOUN
fnp-6282	249	2	article	article	NOUN
fnp-6282	249	3	.	.	PUNCT
fnp-6282	250	1	mol	mol	ADP
fnp-6282	250	2	cell	cell	NOUN
fnp-6282	250	3	biochem	biochem	NOUN
fnp-6282	250	4	47	47	NUM
fnp-6282	250	5	:	:	PUNCT
fnp-6282	250	6	97	97	NUM
fnp-6282	250	7	-	-	SYM
fnp-6282	250	8	113	113	NUM
fnp-6282	250	9	.	.	PUNCT
fnp-6282	250	10	https://doi.org/10.1007/bf00234410	https://doi.org/10.1007/bf00234410	PROPN
fnp-6282	250	11	14	14	NUM
fnp-6282	250	12	.	.	PUNCT
fnp-6282	251	1	chang	chang	PROPN
fnp-6282	251	2	cc	cc	PROPN
fnp-6282	251	3	,	,	PUNCT
fnp-6282	251	4	keppeke	keppeke	VERB
fnp-6282	251	5	gd	gd	PROPN
fnp-6282	251	6	,	,	PUNCT
fnp-6282	251	7	sung	sing	VERB
fnp-6282	251	8	ly	ly	PROPN
fnp-6282	251	9	,	,	PUNCT
fnp-6282	251	10	liu	liu	PROPN
fnp-6282	251	11	jl	jl	PROPN
fnp-6282	251	12	(	(	PUNCT
fnp-6282	251	13	2018	2018	NUM
fnp-6282	251	14	)	)	PUNCT
fnp-6282	251	15	interfilament	interfilament	ADJ
fnp-6282	251	16	interaction	interaction	NOUN
fnp-6282	251	17	between	between	ADP
fnp-6282	251	18	impdh	impdh	NOUN
fnp-6282	251	19	and	and	CCONJ
fnp-6282	251	20	ctps	ctps	NOUN
fnp-6282	251	21	cytoophidia	cytoophidia	PROPN
fnp-6282	251	22	.	.	PUNCT
fnp-6282	252	1	febs	febs	PROPN
fnp-6282	252	2	j	j	PROPN
fnp-6282	252	3	285	285	NUM
fnp-6282	252	4	:	:	PUNCT
fnp-6282	252	5	3753	3753	NUM
fnp-6282	252	6	-	-	SYM
fnp-6282	252	7	3768	3768	NUM
fnp-6282	252	8	.	.	PUNCT
fnp-6282	253	1	https://doi.org/10.1111/febs.14624	https://doi.org/10.1111/febs.14624	PROPN
fnp-6282	253	2	15	15	NUM
fnp-6282	253	3	.	.	PUNCT
fnp-6282	254	1	chang	chang	PROPN
fnp-6282	254	2	cc	cc	PROPN
fnp-6282	254	3	,	,	PUNCT
fnp-6282	254	4	lin	lin	PROPN
fnp-6282	254	5	wc	wc	PROPN
fnp-6282	254	6	,	,	PUNCT
fnp-6282	254	7	pai	pai	PROPN
fnp-6282	254	8	lm	lm	PROPN
fnp-6282	254	9	,	,	PUNCT
fnp-6282	254	10	lee	lee	PROPN
fnp-6282	254	11	hs	hs	PROPN
fnp-6282	254	12	,	,	PUNCT
fnp-6282	254	13	wu	wu	PROPN
fnp-6282	254	14	sc	sc	PROPN
fnp-6282	254	15	,	,	PUNCT
fnp-6282	254	16	ding	ding	PROPN
fnp-6282	254	17	st	st	PROPN
fnp-6282	254	18	,	,	PUNCT
fnp-6282	254	19	liu	liu	PROPN
fnp-6282	254	20	jl	jl	PROPN
fnp-6282	254	21	,	,	PUNCT
fnp-6282	254	22	sung	sing	VERB
fnp-6282	254	23	ly	ly	X
fnp-6282	254	24	(	(	PUNCT
fnp-6282	254	25	2015	2015	NUM
fnp-6282	254	26	)	)	PUNCT
fnp-6282	254	27	cytoophidium	cytoophidium	NOUN
fnp-6282	254	28	assembly	assembly	NOUN
fnp-6282	254	29	reflects	reflect	VERB
fnp-6282	254	30	upregulation	upregulation	NOUN
fnp-6282	254	31	of	of	ADP
fnp-6282	254	32	impdh	impdh	NOUN
fnp-6282	254	33	activity	activity	NOUN
fnp-6282	254	34	.	.	PUNCT
fnp-6282	255	1	j	j	PROPN
fnp-6282	255	2	cell	cell	NOUN
fnp-6282	255	3	sci	sci	PROPN
fnp-6282	255	4	128	128	NUM
fnp-6282	255	5	:	:	PUNCT
fnp-6282	255	6	3550	3550	NUM
fnp-6282	255	7	-	-	SYM
fnp-6282	255	8	3555	3555	NUM
fnp-6282	255	9	.	.	PUNCT
fnp-6282	256	1	https://doi.org/10.1242/jcs.175265	https://doi.org/10.1242/jcs.175265	NOUN
fnp-6282	256	2	16	16	NUM
fnp-6282	256	3	.	.	PUNCT
fnp-6282	257	1	de	de	PROPN
fnp-6282	257	2	brouwer	brouwer	PROPN
fnp-6282	257	3	ap	ap	PROPN
fnp-6282	257	4	,	,	PUNCT
fnp-6282	257	5	van	van	PROPN
fnp-6282	257	6	bokhoven	bokhoven	NOUN
fnp-6282	257	7	h	h	PROPN
fnp-6282	257	8	,	,	PUNCT
fnp-6282	257	9	nabuurs	nabuurs	PROPN
fnp-6282	257	10	sb	sb	PROPN
fnp-6282	257	11	,	,	PUNCT
fnp-6282	257	12	arts	arts	PROPN
fnp-6282	257	13	wf	wf	PROPN
fnp-6282	257	14	,	,	PUNCT
fnp-6282	257	15	christodoulou	christodoulou	PROPN
fnp-6282	257	16	j	j	PROPN
fnp-6282	257	17	,	,	PUNCT
fnp-6282	257	18	duley	duley	PROPN
fnp-6282	257	19	j	j	PROPN
fnp-6282	257	20	(	(	PUNCT
fnp-6282	257	21	2010	2010	NUM
fnp-6282	257	22	)	)	PUNCT
fnp-6282	257	23	prps1	prps1	NOUN
fnp-6282	258	1	mutations	mutation	NOUN
fnp-6282	258	2	:	:	PUNCT
fnp-6282	258	3	four	four	NUM
fnp-6282	258	4	distinct	distinct	ADJ
fnp-6282	258	5	syndromes	syndrome	NOUN
fnp-6282	258	6	and	and	CCONJ
fnp-6282	258	7	potential	potential	ADJ
fnp-6282	258	8	treatment	treatment	NOUN
fnp-6282	258	9	.	.	PUNCT
fnp-6282	258	10	am	be	AUX
fnp-6282	258	11	j	j	PROPN
fnp-6282	258	12	hum	hum	PROPN
fnp-6282	258	13	genet	genet	PROPN
fnp-6282	258	14	86	86	NUM
fnp-6282	258	15	:	:	SYM
fnp-6282	258	16	506	506	NUM
fnp-6282	258	17	-	-	SYM
fnp-6282	258	18	518	518	NUM
fnp-6282	258	19	.	.	PUNCT
fnp-6282	259	1	https://doi.org/10.1016/j.ajhg.2010.02.024	https://doi.org/10.1016/j.ajhg.2010.02.024	NUM
fnp-6282	259	2	17	17	NUM
fnp-6282	259	3	.	.	PUNCT
fnp-6282	259	4	de	de	PROPN
fnp-6282	259	5	brouwer	brouwer	PROPN
fnp-6282	259	6	ap	ap	PROPN
fnp-6282	259	7	,	,	PUNCT
fnp-6282	259	8	williams	williams	PROPN
fnp-6282	259	9	kl	kl	PROPN
fnp-6282	259	10	,	,	PUNCT
fnp-6282	259	11	duley	duley	PROPN
fnp-6282	259	12	ja	ja	PROPN
fnp-6282	259	13	,	,	PUNCT
fnp-6282	259	14	van	van	PROPN
fnp-6282	259	15	kuilenburg	kuilenburg	PROPN
fnp-6282	259	16	ab	ab	PROPN
fnp-6282	259	17	,	,	PUNCT
fnp-6282	259	18	nabuurs	nabuurs	PROPN
fnp-6282	259	19	sb	sb	PROPN
fnp-6282	259	20	,	,	PUNCT
fnp-6282	259	21	egmont	egmont	NOUN
fnp-6282	259	22	-	-	PUNCT
fnp-6282	259	23	petersen	petersen	PROPN
fnp-6282	259	24	m	m	PROPN
fnp-6282	259	25	,	,	PUNCT
fnp-6282	259	26	lugtenberg	lugtenberg	PROPN
fnp-6282	259	27	d	d	PROPN
fnp-6282	259	28	,	,	PUNCT
fnp-6282	259	29	zoetekouw	zoetekouw	PROPN
fnp-6282	259	30	l	l	PROPN
fnp-6282	259	31	,	,	PUNCT
fnp-6282	259	32	banning	ban	VERB
fnp-6282	259	33	mj	mj	PROPN
fnp-6282	259	34	,	,	PUNCT
fnp-6282	259	35	roeffen	roeffen	NOUN
fnp-6282	259	36	met	meet	VERB
fnp-6282	259	37	al	al	PROPN
fnp-6282	259	38	(	(	PUNCT
fnp-6282	259	39	2007	2007	NUM
fnp-6282	259	40	)	)	PUNCT
fnp-6282	259	41	arts	art	NOUN
fnp-6282	259	42	syndrome	syndrome	NOUN
fnp-6282	259	43	is	be	AUX
fnp-6282	259	44	caused	cause	VERB
fnp-6282	259	45	by	by	ADP
fnp-6282	259	46	loss	loss	NOUN
fnp-6282	259	47	-	-	PUNCT
fnp-6282	259	48	of	of	ADP
fnp-6282	259	49	-	-	PUNCT
fnp-6282	259	50	function	function	NOUN
fnp-6282	259	51	mutations	mutation	NOUN
fnp-6282	259	52	in	in	ADP
fnp-6282	259	53	prps1	prps1	PROPN
fnp-6282	259	54	.	.	PUNCT
fnp-6282	260	1	am	be	AUX
fnp-6282	260	2	j	j	PROPN
fnp-6282	260	3	hum	hum	PROPN
fnp-6282	260	4	genet	genet	PROPN
fnp-6282	260	5	81	81	NUM
fnp-6282	260	6	:	:	PUNCT
fnp-6282	260	7	507	507	NUM
fnp-6282	260	8	-	-	SYM
fnp-6282	260	9	518	518	NUM
fnp-6282	260	10	.	.	PUNCT
fnp-6282	261	1	https://doi.org/10.1086/520706	https://doi.org/10.1086/520706	PROPN
fnp-6282	261	2	18	18	NUM
fnp-6282	261	3	.	.	PUNCT
fnp-6282	262	1	dickson	dickson	PROPN
fnp-6282	262	2	dw	dw	PROPN
fnp-6282	262	3	,	,	PUNCT
fnp-6282	262	4	bergeron	bergeron	PROPN
fnp-6282	262	5	c	c	PROPN
fnp-6282	262	6	,	,	PUNCT
fnp-6282	262	7	chin	chin	PROPN
fnp-6282	262	8	ss	ss	PROPN
fnp-6282	262	9	,	,	PUNCT
fnp-6282	262	10	duyckaerts	duyckaert	NOUN
fnp-6282	262	11	c	c	PROPN
fnp-6282	262	12	,	,	PUNCT
fnp-6282	262	13	horoupian	horoupian	PROPN
fnp-6282	262	14	d	d	PROPN
fnp-6282	262	15	,	,	PUNCT
fnp-6282	262	16	ikeda	ikeda	PROPN
fnp-6282	262	17	k	k	PROPN
fnp-6282	262	18	,	,	PUNCT
fnp-6282	262	19	jellinger	jellinger	PROPN
fnp-6282	262	20	k	k	PROPN
fnp-6282	262	21	,	,	PUNCT
fnp-6282	262	22	lantos	lantos	PROPN
fnp-6282	262	23	pl	pl	PROPN
fnp-6282	262	24	,	,	PUNCT
fnp-6282	262	25	lippa	lippa	ADJ
fnp-6282	262	26	cf	cf	NOUN
fnp-6282	262	27	,	,	PUNCT
fnp-6282	262	28	mirra	mirra	NOUN
fnp-6282	262	29	sset	sset	VERB
fnp-6282	262	30	al	al	PROPN
fnp-6282	262	31	(	(	PUNCT
fnp-6282	262	32	2002	2002	NUM
fnp-6282	262	33	)	)	PUNCT
fnp-6282	262	34	office	office	NOUN
fnp-6282	262	35	of	of	ADP
fnp-6282	262	36	rare	rare	ADJ
fnp-6282	262	37	diseases	disease	NOUN
fnp-6282	262	38	neuropathologic	neuropathologic	ADJ
fnp-6282	262	39	criteria	criterion	NOUN
fnp-6282	262	40	for	for	ADP
fnp-6282	262	41	corticobasal	corticobasal	NOUN
fnp-6282	262	42	degeneration	degeneration	NOUN
fnp-6282	262	43	.	.	PUNCT
fnp-6282	263	1	j	j	PROPN
fnp-6282	263	2	neuropathol	neuropathol	PROPN
fnp-6282	263	3	exp	exp	PROPN
fnp-6282	263	4	neurol	neurol	PROPN
fnp-6282	263	5	61	61	NUM
fnp-6282	263	6	:	:	PUNCT
fnp-6282	263	7	935	935	NUM
fnp-6282	263	8	-	-	SYM
fnp-6282	263	9	946	946	NUM
fnp-6282	263	10	.	.	PUNCT
fnp-6282	264	1	https://doi.org/10.1093/jnen/61.11.935	https://doi.org/10.1093/jnen/61.11.935	PROPN
fnp-6282	264	2	19	19	NUM
fnp-6282	264	3	.	.	PUNCT
fnp-6282	265	1	duman	duman	PROPN
fnp-6282	265	2	jg	jg	PROPN
fnp-6282	265	3	,	,	PUNCT
fnp-6282	265	4	mulherkar	mulherkar	PROPN
fnp-6282	265	5	s	s	PROPN
fnp-6282	265	6	,	,	PUNCT
fnp-6282	265	7	tu	tu	PROPN
fnp-6282	265	8	yk	yk	PROPN
fnp-6282	265	9	,	,	PUNCT
fnp-6282	265	10	j	j	PROPN
fnp-6282	265	11	xc	xc	PROPN
fnp-6282	265	12	,	,	PUNCT
fnp-6282	265	13	tolias	tolias	PROPN
fnp-6282	265	14	kf	kf	PROPN
fnp-6282	265	15	(	(	PUNCT
fnp-6282	265	16	2015	2015	NUM
fnp-6282	265	17	)	)	PUNCT
fnp-6282	265	18	mechanisms	mechanism	NOUN
fnp-6282	265	19	for	for	ADP
fnp-6282	265	20	spatiotemporal	spatiotemporal	ADJ
fnp-6282	265	21	regulation	regulation	NOUN
fnp-6282	265	22	of	of	ADP
fnp-6282	265	23	rho	rho	ADJ
fnp-6282	265	24	-	-	NOUN
fnp-6282	265	25	gtpase	gtpase	NOUN
fnp-6282	265	26	signaling	signal	VERB
fnp-6282	265	27	at	at	ADP
fnp-6282	265	28	synapses	synapsis	NOUN
fnp-6282	265	29	.	.	PUNCT
fnp-6282	266	1	neurosci	neurosci	PROPN
fnp-6282	266	2	lett	lett	PROPN
fnp-6282	266	3	601	601	NUM
fnp-6282	266	4	:	:	PUNCT
fnp-6282	266	5	4	4	NUM
fnp-6282	266	6	-	-	SYM
fnp-6282	266	7	10	10	NUM
fnp-6282	266	8	.	.	PUNCT
fnp-6282	267	1	https://doi.org/10.1016/j.neulet.2015.05.034	https://doi.org/10.1016/j.neulet.2015.05.034	NOUN
fnp-6282	267	2	20	20	NUM
fnp-6282	267	3	.	.	PUNCT
fnp-6282	268	1	espinar	espinar	PROPN
fnp-6282	268	2	l	l	PROPN
fnp-6282	268	3	,	,	PUNCT
fnp-6282	268	4	garcia	garcia	PROPN
fnp-6282	268	5	-	-	PUNCT
fnp-6282	268	6	cao	cao	PROPN
fnp-6282	268	7	m	m	PROPN
fnp-6282	268	8	,	,	PUNCT
fnp-6282	268	9	schmidt	schmidt	PROPN
fnp-6282	268	10	a	a	PRON
fnp-6282	268	11	,	,	PUNCT
fnp-6282	268	12	kourtis	kourtis	PROPN
fnp-6282	268	13	s	s	PROPN
fnp-6282	268	14	,	,	PUNCT
fnp-6282	268	15	ganez	ganez	PROPN
fnp-6282	268	16	zapater	zapater	NOUN
fnp-6282	268	17	a	a	NOUN
fnp-6282	268	18	,	,	PUNCT
fnp-6282	268	19	aranda	aranda	PROPN
fnp-6282	268	20	-	-	PUNCT
fnp-6282	268	21	vallejo	vallejo	PROPN
fnp-6282	268	22	c	c	PROPN
fnp-6282	268	23	,	,	PUNCT
fnp-6282	268	24	ghose	ghose	PROPN
fnp-6282	268	25	r	r	PROPN
fnp-6282	268	26	,	,	PUNCT
fnp-6282	268	27	garcia	garcia	PROPN
fnp-6282	268	28	-	-	PUNCT
fnp-6282	268	29	lopez	lopez	PROPN
fnp-6282	268	30	l	l	PROPN
fnp-6282	268	31	,	,	PUNCT
fnp-6282	268	32	sheraj	sheraj	VERB
fnp-6282	268	33	i	i	PROPN
fnp-6282	268	34	,	,	PUNCT
fnp-6282	268	35	pardo	pardo	PROPN
fnp-6282	268	36	-	-	PUNCT
fnp-6282	268	37	lorente	lorente	PROPN
fnp-6282	268	38	net	net	NOUN
fnp-6282	268	39	al	al	PROPN
fnp-6282	268	40	(	(	PUNCT
fnp-6282	268	41	2024	2024	NUM
fnp-6282	268	42	)	)	PUNCT
fnp-6282	268	43	nuclear	nuclear	ADJ
fnp-6282	268	44	impdh2	impdh2	PROPN
fnp-6282	268	45	controls	control	VERB
fnp-6282	268	46	the	the	DET
fnp-6282	268	47	dna	dna	PROPN
fnp-6282	268	48	damage	damage	NOUN
fnp-6282	268	49	response	response	NOUN
fnp-6282	268	50	by	by	ADP
fnp-6282	268	51	modulating	modulate	VERB
fnp-6282	268	52	parp1	parp1	NOUN
fnp-6282	268	53	activity	activity	NOUN
fnp-6282	268	54	.	.	PUNCT
fnp-6282	269	1	nature	nature	NOUN
fnp-6282	269	2	communications	communication	NOUN
fnp-6282	269	3	15	15	NUM
fnp-6282	269	4	:	:	SYM
fnp-6282	269	5	9515	9515	NUM
fnp-6282	269	6	.	.	PUNCT
fnp-6282	270	1	https://doi.org/10.1038/s41467-024-53877-z	https://doi.org/10.1038/s41467-024-53877-z	PROPN
fnp-6282	270	2	21	21	NUM
fnp-6282	270	3	.	.	PUNCT
fnp-6282	271	1	flores	flores	PROPN
fnp-6282	271	2	-	-	PUNCT
fnp-6282	271	3	mendez	mendez	PROPN
fnp-6282	271	4	m	m	PROPN
fnp-6282	271	5	,	,	PUNCT
fnp-6282	271	6	ohl	ohl	PROPN
fnp-6282	271	7	l	l	PROPN
fnp-6282	271	8	,	,	PUNCT
fnp-6282	271	9	roule	roule	PROPN
fnp-6282	271	10	t	t	PROPN
fnp-6282	271	11	,	,	PUNCT
fnp-6282	271	12	zhou	zhou	PROPN
fnp-6282	271	13	y	y	PROPN
fnp-6282	271	14	,	,	PUNCT
fnp-6282	271	15	tintos	tintos	NOUN
fnp-6282	271	16	-	-	PUNCT
fnp-6282	271	17	hernandez	hernandez	PROPN
fnp-6282	271	18	ja	ja	PROPN
fnp-6282	271	19	,	,	PUNCT
fnp-6282	271	20	walsh	walsh	PROPN
fnp-6282	271	21	k	k	PROPN
fnp-6282	271	22	,	,	PUNCT
fnp-6282	271	23	ortiz	ortiz	PROPN
fnp-6282	271	24	-	-	PUNCT
fnp-6282	271	25	gonzalez	gonzalez	PROPN
fnp-6282	271	26	xr	xr	PROPN
fnp-6282	271	27	,	,	PUNCT
fnp-6282	271	28	akizu	akizu	PROPN
fnp-6282	271	29	n	n	PROPN
fnp-6282	271	30	(	(	PUNCT
fnp-6282	271	31	2024	2024	NUM
fnp-6282	271	32	)	)	PUNCT
fnp-6282	271	33	impdh2	impdh2	NOUN
fnp-6282	271	34	filaments	filament	NOUN
fnp-6282	271	35	protect	protect	VERB
fnp-6282	271	36	from	from	ADP
fnp-6282	271	37	neurodegeneration	neurodegeneration	NOUN
fnp-6282	271	38	in	in	ADP
fnp-6282	271	39	ampd2	ampd2	NOUN
fnp-6282	271	40	deficiency	deficiency	NOUN
fnp-6282	271	41	.	.	PUNCT
fnp-6282	272	1	embo	embo	PROPN
fnp-6282	272	2	rep	rep	PROPN
fnp-6282	272	3	25	25	NUM
fnp-6282	272	4	:	:	SYM
fnp-6282	272	5	3990	3990	NUM
fnp-6282	272	6	4012	4012	NUM
fnp-6282	272	7	:	:	PUNCT
fnp-6282	272	8	.	.	PUNCT
fnp-6282	273	1	https://doi.org/10.1038/s44319-024-00218-2	https://doi.org/10.1038/s44319-024-00218-2	NUM
fnp-6282	273	2	22	22	NUM
fnp-6282	273	3	.	.	PUNCT
fnp-6282	274	1	french	french	PROPN
fnp-6282	274	2	jb	jb	PROPN
fnp-6282	274	3	,	,	PUNCT
fnp-6282	274	4	jones	jones	PROPN
fnp-6282	274	5	sa	sa	PROPN
fnp-6282	274	6	,	,	PUNCT
fnp-6282	274	7	deng	deng	PROPN
fnp-6282	274	8	h	h	PROPN
fnp-6282	274	9	,	,	PUNCT
fnp-6282	274	10	pedley	pedley	PROPN
fnp-6282	274	11	am	am	PROPN
fnp-6282	274	12	,	,	PUNCT
fnp-6282	274	13	kim	kim	PROPN
fnp-6282	274	14	d	d	PROPN
fnp-6282	274	15	,	,	PUNCT
fnp-6282	274	16	chan	chan	PROPN
fnp-6282	274	17	cy	cy	PROPN
fnp-6282	274	18	,	,	PUNCT
fnp-6282	274	19	hu	hu	PROPN
fnp-6282	274	20	h	h	PROPN
fnp-6282	274	21	,	,	PUNCT
fnp-6282	274	22	pugh	pugh	PROPN
fnp-6282	274	23	rj	rj	PROPN
fnp-6282	274	24	,	,	PUNCT
fnp-6282	274	25	zhao	zhao	PROPN
fnp-6282	274	26	h	h	PROPN
fnp-6282	274	27	,	,	PUNCT
fnp-6282	274	28	zhang	zhang	PROPN
fnp-6282	274	29	yet	yet	PROPN
fnp-6282	274	30	al	al	PROPN
fnp-6282	274	31	(	(	PUNCT
fnp-6282	274	32	2016	2016	NUM
fnp-6282	274	33	)	)	PUNCT
fnp-6282	274	34	spatial	spatial	ADJ
fnp-6282	274	35	colocalization	colocalization	NOUN
fnp-6282	274	36	and	and	CCONJ
fnp-6282	274	37	functional	functional	ADJ
fnp-6282	274	38	link	link	NOUN
fnp-6282	274	39	of	of	ADP
fnp-6282	274	40	purinosomes	purinosome	NOUN
fnp-6282	274	41	with	with	ADP
fnp-6282	274	42	mitochondria	mitochondria	PROPN
fnp-6282	274	43	.	.	PUNCT
fnp-6282	275	1	science	science	NOUN
fnp-6282	275	2	351	351	NUM
fnp-6282	275	3	:	:	PUNCT
fnp-6282	275	4	733	733	NUM
fnp-6282	275	5	-	-	SYM
fnp-6282	275	6	737	737	NUM
fnp-6282	275	7	.	.	PUNCT
fnp-6282	276	1	https://doi.org/10.1126/science.aac6054	https://doi.org/10.1126/science.aac6054	PROPN
fnp-6282	276	2	23	23	NUM
fnp-6282	276	3	.	.	PUNCT
fnp-6282	277	1	gysbers	gysber	NOUN
fnp-6282	277	2	jw	jw	PROPN
fnp-6282	277	3	,	,	PUNCT
fnp-6282	277	4	rathbone	rathbone	PROPN
fnp-6282	277	5	mp	mp	PROPN
fnp-6282	277	6	(	(	PUNCT
fnp-6282	277	7	1992	1992	NUM
fnp-6282	277	8	)	)	PUNCT
fnp-6282	277	9	guanosine	guanosine	NOUN
fnp-6282	277	10	enhances	enhance	VERB
fnp-6282	277	11	ngf	ngf	ADV
fnp-6282	277	12	-	-	PUNCT
fnp-6282	277	13	stimulated	stimulate	VERB
fnp-6282	277	14	neurite	neurite	NOUN
fnp-6282	277	15	outgrowth	outgrowth	NOUN
fnp-6282	277	16	in	in	ADP
fnp-6282	277	17	pc12	pc12	PROPN
fnp-6282	277	18	cells	cell	NOUN
fnp-6282	277	19	.	.	PUNCT
fnp-6282	278	1	neuroreport	neuroreport	NOUN
fnp-6282	278	2	3	3	NUM
fnp-6282	278	3	:	:	PUNCT
fnp-6282	278	4	997	997	NUM
fnp-6282	278	5	-	-	SYM
fnp-6282	278	6	1000	1000	NUM
fnp-6282	278	7	.	.	PUNCT
fnp-6282	279	1	https://doi.org/10.1097/00001756-199211000-00013	https://doi.org/10.1097/00001756-199211000-00013	NOUN
fnp-6282	279	2	24	24	NUM
fnp-6282	279	3	.	.	PUNCT
fnp-6282	280	1	gysbers	gysbers	PROPN
fnp-6282	280	2	jw	jw	PROPN
fnp-6282	280	3	,	,	PUNCT
fnp-6282	280	4	rathbone	rathbone	PROPN
fnp-6282	280	5	mp	mp	PROPN
fnp-6282	280	6	(	(	PUNCT
fnp-6282	280	7	1996	1996	NUM
fnp-6282	280	8	)	)	PUNCT
fnp-6282	280	9	neurite	neurite	NOUN
fnp-6282	280	10	outgrowth	outgrowth	NOUN
fnp-6282	280	11	in	in	ADP
fnp-6282	280	12	pc12	pc12	PROPN
fnp-6282	280	13	cells	cell	NOUN
fnp-6282	280	14	is	be	AUX
fnp-6282	280	15	enhanced	enhance	VERB
fnp-6282	280	16	by	by	ADP
fnp-6282	280	17	guanosine	guanosine	NOUN
fnp-6282	280	18	through	through	ADP
fnp-6282	280	19	both	both	DET
fnp-6282	280	20	camp	camp	NOUN
fnp-6282	280	21	-	-	PUNCT
fnp-6282	280	22	dependent	dependent	ADJ
fnp-6282	280	23	and	and	CCONJ
fnp-6282	280	24	-independent	-independent	ADJ
fnp-6282	280	25	mechanisms	mechanism	NOUN
fnp-6282	280	26	.	.	PUNCT
fnp-6282	281	1	neurosci	neurosci	PROPN
fnp-6282	281	2	lett	lett	PROPN
fnp-6282	281	3	220	220	NUM
fnp-6282	281	4	:	:	PUNCT
fnp-6282	281	5	175	175	NUM
fnp-6282	281	6	-	-	SYM
fnp-6282	281	7	178	178	NUM
fnp-6282	281	8	.	.	PUNCT
fnp-6282	282	1	https://doi.org/10.1016/s0304-3940(96)13253-5	https://doi.org/10.1016/s0304-3940(96)13253-5	PROPN
fnp-6282	282	2	25	25	NUM
fnp-6282	282	3	.	.	PUNCT
fnp-6282	283	1	hvorecny	hvorecny	PROPN
fnp-6282	283	2	kl	kl	PROPN
fnp-6282	283	3	,	,	PUNCT
fnp-6282	283	4	hargett	hargett	PROPN
fnp-6282	283	5	k	k	PROPN
fnp-6282	283	6	,	,	PUNCT
fnp-6282	283	7	quispe	quispe	PROPN
fnp-6282	283	8	jd	jd	PROPN
fnp-6282	283	9	,	,	PUNCT
fnp-6282	283	10	kollman	kollman	PROPN
fnp-6282	283	11	jm	jm	PROPN
fnp-6282	283	12	(	(	PUNCT
fnp-6282	283	13	2023	2023	NUM
fnp-6282	283	14	)	)	PUNCT
fnp-6282	283	15	human	human	ADJ
fnp-6282	283	16	prps1	prps1	NOUN
fnp-6282	283	17	filaments	filament	NOUN
fnp-6282	283	18	stabilize	stabilize	VERB
fnp-6282	283	19	allosteric	allosteric	ADJ
fnp-6282	283	20	sites	site	NOUN
fnp-6282	283	21	to	to	PART
fnp-6282	283	22	regulate	regulate	VERB
fnp-6282	283	23	activity	activity	NOUN
fnp-6282	283	24	.	.	PUNCT
fnp-6282	284	1	nat	nat	PROPN
fnp-6282	284	2	struct	struct	NOUN
fnp-6282	284	3	mol	mol	ADP
fnp-6282	284	4	biol	biol	PROPN
fnp-6282	284	5	30	30	NUM
fnp-6282	284	6	:	:	PUNCT
fnp-6282	284	7	391	391	NUM
fnp-6282	284	8	-	-	SYM
fnp-6282	284	9	402	402	NUM
fnp-6282	284	10	.	.	PUNCT
fnp-6282	285	1	https://doi.org/10.1038/s41594-023-00921-z	https://doi.org/10.1038/s41594-023-00921-z	PROPN
fnp-6282	285	2	26	26	NUM
fnp-6282	285	3	.	.	PUNCT
fnp-6282	286	1	isobe	isobe	PROPN
fnp-6282	286	2	c	c	PROPN
fnp-6282	286	3	,	,	PUNCT
fnp-6282	286	4	abe	abe	PROPN
fnp-6282	286	5	t	t	PROPN
fnp-6282	286	6	,	,	PUNCT
fnp-6282	286	7	terayama	terayama	NOUN
fnp-6282	286	8	y	y	PROPN
fnp-6282	286	9	(	(	PUNCT
fnp-6282	286	10	2010	2010	NUM
fnp-6282	286	11	)	)	PUNCT
fnp-6282	286	12	levels	level	NOUN
fnp-6282	286	13	of	of	ADP
fnp-6282	286	14	reduced	reduce	VERB
fnp-6282	286	15	and	and	CCONJ
fnp-6282	286	16	oxidized	oxidize	VERB
fnp-6282	286	17	coenzyme	coenzyme	PROPN
fnp-6282	286	18	q-10	q-10	PROPN
fnp-6282	286	19	and	and	CCONJ
fnp-6282	286	20	8	8	NUM
fnp-6282	286	21	-	-	PUNCT
fnp-6282	286	22	hydroxy-2'-deoxyguanosine	hydroxy-2'-deoxyguanosine	NOUN
fnp-6282	286	23	in	in	ADP
fnp-6282	286	24	the	the	DET
fnp-6282	286	25	csf	csf	NOUN
fnp-6282	286	26	of	of	ADP
fnp-6282	286	27	patients	patient	NOUN
fnp-6282	286	28	with	with	ADP
fnp-6282	286	29	alzheimer	alzheimer	PROPN
fnp-6282	286	30	's	's	PART
fnp-6282	286	31	disease	disease	NOUN
fnp-6282	286	32	demonstrate	demonstrate	VERB
fnp-6282	286	33	that	that	SCONJ
fnp-6282	286	34	mitochondrial	mitochondrial	ADJ
fnp-6282	286	35	oxidative	oxidative	ADJ
fnp-6282	286	36	damage	damage	NOUN
fnp-6282	286	37	and/or	and/or	CCONJ
fnp-6282	286	38	oxidative	oxidative	ADJ
fnp-6282	286	39	dna	dna	PROPN
fnp-6282	286	40	damage	damage	NOUN
fnp-6282	286	41	contributes	contribute	VERB
fnp-6282	286	42	to	to	ADP
fnp-6282	286	43	the	the	DET
fnp-6282	286	44	neurodegenerative	neurodegenerative	ADJ
fnp-6282	286	45	process	process	NOUN
fnp-6282	286	46	.	.	PUNCT
fnp-6282	287	1	j	j	PROPN
fnp-6282	287	2	neurol	neurol	NOUN
fnp-6282	287	3	257	257	NUM
fnp-6282	287	4	:	:	PUNCT
fnp-6282	287	5	399	399	NUM
fnp-6282	287	6	-	-	SYM
fnp-6282	287	7	404	404	NUM
fnp-6282	287	8	.	.	PUNCT
fnp-6282	288	1	https://doi.org/10.1007/s00415-009-5333-x	https://doi.org/10.1007/s00415-009-5333-x	PROPN
fnp-6282	288	2	27	27	NUM
fnp-6282	288	3	.	.	PUNCT
fnp-6282	289	1	jinnah	jinnah	PROPN
fnp-6282	289	2	ha	ha	PROPN
fnp-6282	289	3	,	,	PUNCT
fnp-6282	289	4	sabina	sabina	PROPN
fnp-6282	289	5	rl	rl	PROPN
fnp-6282	289	6	,	,	PUNCT
fnp-6282	289	7	van	van	PROPN
fnp-6282	289	8	den	den	PROPN
fnp-6282	289	9	berghe	berghe	NOUN
fnp-6282	289	10	g	g	PROPN
fnp-6282	289	11	(	(	PUNCT
fnp-6282	289	12	2013	2013	NUM
fnp-6282	289	13	)	)	PUNCT
fnp-6282	289	14	metabolic	metabolic	NOUN
fnp-6282	289	15	disorders	disorder	NOUN
fnp-6282	289	16	of	of	ADP
fnp-6282	289	17	purine	purine	NOUN
fnp-6282	289	18	metabolism	metabolism	NOUN
fnp-6282	289	19	affecting	affect	VERB
fnp-6282	289	20	the	the	DET
fnp-6282	289	21	nervous	nervous	ADJ
fnp-6282	289	22	system	system	NOUN
fnp-6282	289	23	.	.	PUNCT
fnp-6282	290	1	handb	handb	PROPN
fnp-6282	290	2	clin	clin	PROPN
fnp-6282	290	3	neurol	neurol	PROPN
fnp-6282	290	4	113	113	NUM
fnp-6282	290	5	:	:	PUNCT
fnp-6282	290	6	1827	1827	NUM
fnp-6282	290	7	-	-	SYM
fnp-6282	290	8	1836	1836	NUM
fnp-6282	290	9	.	.	PUNCT
fnp-6282	291	1	https://doi.org/10.1016/b978-0-444-59565-2.00052-6	https://doi.org/10.1016/b978-0-444-59565-2.00052-6	NOUN
fnp-6282	291	2	28	28	NUM
fnp-6282	291	3	.	.	PUNCT
fnp-6282	292	1	johnson	johnson	PROPN
fnp-6282	292	2	mc	mc	PROPN
fnp-6282	292	3	,	,	PUNCT
fnp-6282	292	4	kollman	kollman	PROPN
fnp-6282	292	5	jm	jm	PROPN
fnp-6282	292	6	(	(	PUNCT
fnp-6282	292	7	2020	2020	NUM
fnp-6282	292	8	)	)	PUNCT
fnp-6282	292	9	cryo	cryo	NOUN
fnp-6282	292	10	-	-	PUNCT
fnp-6282	292	11	em	em	PROPN
fnp-6282	292	12	structures	structure	NOUN
fnp-6282	292	13	demonstrate	demonstrate	VERB
fnp-6282	292	14	human	human	PROPN
fnp-6282	292	15	impdh2	impdh2	PROPN
fnp-6282	292	16	filament	filament	PROPN
fnp-6282	292	17	assembly	assembly	NOUN
fnp-6282	292	18	tunes	tune	NOUN
fnp-6282	292	19	allosteric	allosteric	ADJ
fnp-6282	292	20	regulation	regulation	NOUN
fnp-6282	292	21	.	.	PUNCT
fnp-6282	293	1	elife	elife	NOUN
fnp-6282	293	2	9	9	NUM
fnp-6282	293	3	:	:	PUNCT
fnp-6282	293	4	.	.	PUNCT
fnp-6282	294	1	https://doi.org/10.7554/elife.53243	https://doi.org/10.7554/elife.53243	PROPN
fnp-6282	294	2	29	29	NUM
fnp-6282	294	3	.	.	PUNCT
fnp-6282	295	1	jove	jove	PROPN
fnp-6282	295	2	m	m	PROPN
fnp-6282	295	3	,	,	PUNCT
fnp-6282	295	4	portero	portero	PROPN
fnp-6282	295	5	-	-	PUNCT
fnp-6282	295	6	otin	otin	PROPN
fnp-6282	295	7	m	m	PROPN
fnp-6282	295	8	,	,	PUNCT
fnp-6282	295	9	naudi	naudi	ADV
fnp-6282	295	10	a	a	X
fnp-6282	295	11	,	,	PUNCT
fnp-6282	295	12	ferrer	ferrer	PROPN
fnp-6282	295	13	i	i	PROPN
fnp-6282	295	14	,	,	PUNCT
fnp-6282	295	15	pamplona	pamplona	PROPN
fnp-6282	295	16	r	r	PROPN
fnp-6282	295	17	(	(	PUNCT
fnp-6282	295	18	2014	2014	NUM
fnp-6282	295	19	)	)	PUNCT
fnp-6282	295	20	metabolomics	metabolomic	NOUN
fnp-6282	295	21	of	of	ADP
fnp-6282	295	22	human	human	ADJ
fnp-6282	295	23	brain	brain	NOUN
fnp-6282	295	24	aging	aging	NOUN
fnp-6282	295	25	and	and	CCONJ
fnp-6282	295	26	age	age	NOUN
fnp-6282	295	27	-	-	PUNCT
fnp-6282	295	28	related	relate	VERB
fnp-6282	295	29	neurodegenerative	neurodegenerative	ADJ
fnp-6282	295	30	diseases	disease	NOUN
fnp-6282	295	31	.	.	PUNCT
fnp-6282	296	1	j	j	PROPN
fnp-6282	296	2	neuropathol	neuropathol	PROPN
fnp-6282	296	3	exp	exp	PROPN
fnp-6282	296	4	neurol	neurol	NOUN
fnp-6282	296	5	73	73	NUM
fnp-6282	296	6	:	:	PUNCT
fnp-6282	296	7	640	640	NUM
fnp-6282	296	8	-	-	SYM
fnp-6282	296	9	657	657	NUM
fnp-6282	296	10	.	.	PUNCT
fnp-6282	297	1	https://doi.org/10.1097/nen.0000000000000091	https://doi.org/10.1097/nen.0000000000000091	PROPN
fnp-6282	297	2	30	30	NUM
fnp-6282	297	3	.	.	PUNCT
fnp-6282	298	1	kaddurah	kaddurah	PROPN
fnp-6282	298	2	-	-	PUNCT
fnp-6282	298	3	daouk	daouk	PROPN
fnp-6282	298	4	r	r	NOUN
fnp-6282	298	5	,	,	PUNCT
fnp-6282	298	6	rozen	rozen	PROPN
fnp-6282	298	7	s	s	PROPN
fnp-6282	298	8	,	,	PUNCT
fnp-6282	298	9	matson	matson	PROPN
fnp-6282	298	10	w	w	PROPN
fnp-6282	298	11	,	,	PUNCT
fnp-6282	298	12	han	han	PROPN
fnp-6282	298	13	x	x	PROPN
fnp-6282	298	14	,	,	PUNCT
fnp-6282	298	15	hulette	hulette	PROPN
fnp-6282	298	16	cm	cm	PROPN
fnp-6282	298	17	,	,	PUNCT
fnp-6282	298	18	burke	burke	PROPN
fnp-6282	298	19	jr	jr	PROPN
fnp-6282	298	20	,	,	PUNCT
fnp-6282	298	21	doraiswamy	doraiswamy	ADJ
fnp-6282	298	22	pm	pm	NOUN
fnp-6282	298	23	,	,	PUNCT
fnp-6282	298	24	welsh	welsh	NOUN
fnp-6282	298	25	-	-	PUNCT
fnp-6282	298	26	bohmer	bohmer	PROPN
fnp-6282	298	27	ka	ka	PROPN
fnp-6282	298	28	(	(	PUNCT
fnp-6282	298	29	2011	2011	NUM
fnp-6282	298	30	)	)	PUNCT
fnp-6282	298	31	metabolomic	metabolomic	ADJ
fnp-6282	298	32	changes	change	NOUN
fnp-6282	298	33	in	in	ADP
fnp-6282	298	34	autopsy	autopsy	NOUN
fnp-6282	298	35	-	-	PUNCT
fnp-6282	298	36	confirmed	confirm	VERB
fnp-6282	298	37	alzheimer	alzheimer	PROPN
fnp-6282	298	38	's	's	PART
fnp-6282	298	39	disease	disease	NOUN
fnp-6282	298	40	.	.	PUNCT
fnp-6282	299	1	alzheimers	alzheimers	PROPN
fnp-6282	299	2	dement	dement	PROPN
fnp-6282	299	3	7	7	NUM
fnp-6282	299	4	:	:	PUNCT
fnp-6282	299	5	309	309	NUM
fnp-6282	299	6	-	-	SYM
fnp-6282	299	7	317	317	NUM
fnp-6282	299	8	.	.	PUNCT
fnp-6282	300	1	https://doi.org/10.1016/j.jalz.2010.06.001	https://doi.org/10.1016/j.jalz.2010.06.001	VERB
fnp-6282	300	2	31	31	NUM
fnp-6282	300	3	.	.	PUNCT
fnp-6282	301	1	kaddurah	kaddurah	PROPN
fnp-6282	301	2	-	-	PUNCT
fnp-6282	301	3	daouk	daouk	PROPN
fnp-6282	301	4	r	r	NOUN
fnp-6282	301	5	,	,	PUNCT
fnp-6282	301	6	zhu	zhu	PROPN
fnp-6282	301	7	h	h	NOUN
fnp-6282	301	8	,	,	PUNCT
fnp-6282	301	9	sharma	sharma	PROPN
fnp-6282	301	10	s	s	PROPN
fnp-6282	301	11	,	,	PUNCT
fnp-6282	301	12	bogdanov	bogdanov	PROPN
fnp-6282	301	13	m	m	PROPN
fnp-6282	301	14	,	,	PUNCT
fnp-6282	301	15	rozen	rozen	PROPN
fnp-6282	301	16	sg	sg	PROPN
fnp-6282	301	17	,	,	PUNCT
fnp-6282	301	18	matson	matson	PROPN
fnp-6282	301	19	w	w	PROPN
fnp-6282	301	20	,	,	PUNCT
fnp-6282	301	21	oki	oki	NOUN
fnp-6282	301	22	no	no	NOUN
fnp-6282	301	23	,	,	PUNCT
fnp-6282	301	24	motsinger	motsinger	ADJ
fnp-6282	301	25	-	-	PUNCT
fnp-6282	301	26	reif	reif	NOUN
fnp-6282	301	27	aa	aa	NOUN
fnp-6282	301	28	,	,	PUNCT
fnp-6282	301	29	churchill	churchill	PROPN
fnp-6282	301	30	e	e	PROPN
fnp-6282	301	31	,	,	PUNCT
fnp-6282	301	32	lei	lei	PROPN
fnp-6282	301	33	zet	zet	PROPN
fnp-6282	301	34	al	al	PROPN
fnp-6282	301	35	(	(	PUNCT
fnp-6282	301	36	2013	2013	NUM
fnp-6282	301	37	)	)	PUNCT
fnp-6282	301	38	alterations	alteration	NOUN
fnp-6282	301	39	in	in	ADP
fnp-6282	301	40	metabolic	metabolic	NOUN
fnp-6282	301	41	pathways	pathway	NOUN
fnp-6282	301	42	and	and	CCONJ
fnp-6282	301	43	networks	network	NOUN
fnp-6282	301	44	in	in	ADP
fnp-6282	301	45	alzheimer	alzheimer	PROPN
fnp-6282	301	46	's	's	PART
fnp-6282	301	47	disease	disease	NOUN
fnp-6282	301	48	.	.	PUNCT
fnp-6282	302	1	transl	transl	PROPN
fnp-6282	302	2	psychiatry	psychiatry	NOUN
fnp-6282	302	3	3	3	NUM
fnp-6282	302	4	:	:	PUNCT
fnp-6282	302	5	e244	e244	PROPN
fnp-6282	302	6	.	.	PUNCT
fnp-6282	303	1	https://doi.org/10.1038/tp.2013.18	https://doi.org/10.1038/tp.2013.18	PROPN
fnp-6282	303	2	32	32	NUM
fnp-6282	303	3	.	.	PUNCT
fnp-6282	304	1	kaida	kaida	PROPN
fnp-6282	304	2	a	a	DET
fnp-6282	304	3	,	,	PUNCT
fnp-6282	304	4	ariumi	ariumi	NOUN
fnp-6282	304	5	y	y	PROPN
fnp-6282	304	6	,	,	PUNCT
fnp-6282	304	7	baba	baba	PROPN
fnp-6282	304	8	k	k	PROPN
fnp-6282	304	9	,	,	PUNCT
fnp-6282	304	10	matsubae	matsubae	PROPN
fnp-6282	304	11	m	m	PROPN
fnp-6282	304	12	,	,	PUNCT
fnp-6282	304	13	takao	takao	PROPN
fnp-6282	304	14	t	t	PROPN
fnp-6282	304	15	,	,	PUNCT
fnp-6282	304	16	shimotohno	shimotohno	NOUN
fnp-6282	304	17	k	k	PROPN
fnp-6282	304	18	(	(	PUNCT
fnp-6282	304	19	2005	2005	NUM
fnp-6282	304	20	)	)	PUNCT
fnp-6282	304	21	identification	identification	NOUN
fnp-6282	304	22	of	of	ADP
fnp-6282	304	23	a	a	DET
fnp-6282	304	24	novel	novel	ADJ
fnp-6282	304	25	p300	p300	NUM
fnp-6282	304	26	-	-	PUNCT
fnp-6282	304	27	specific	specific	ADJ
fnp-6282	304	28	-	-	PUNCT
fnp-6282	304	29	associating	associate	VERB
fnp-6282	304	30	protein	protein	NOUN
fnp-6282	304	31	,	,	PUNCT
fnp-6282	304	32	prs1	prs1	NOUN
fnp-6282	304	33	(	(	PUNCT
fnp-6282	304	34	phosphoribosylpyrophosphate	phosphoribosylpyrophosphate	NOUN
fnp-6282	304	35	synthetase	synthetase	NOUN
fnp-6282	304	36	subunit	subunit	NOUN
fnp-6282	304	37	1	1	NUM
fnp-6282	304	38	)	)	PUNCT
fnp-6282	304	39	.	.	PUNCT
fnp-6282	305	1	biochem	biochem	PROPN
fnp-6282	305	2	j.	j.	PROPN
fnp-6282	305	3	391	391	NUM
fnp-6282	305	4	:	:	PUNCT
fnp-6282	305	5	239	239	NUM
fnp-6282	305	6	-	-	SYM
fnp-6282	305	7	247	247	NUM
fnp-6282	305	8	.	.	PUNCT
fnp-6282	306	1	https://doi.org/10.1042/bj20041308	https://doi.org/10.1042/bj20041308	NUM
fnp-6282	306	2	33	33	NUM
fnp-6282	306	3	.	.	PUNCT
fnp-6282	307	1	keppeke	keppeke	PROPN
fnp-6282	307	2	gd	gd	PROPN
fnp-6282	307	3	,	,	PUNCT
fnp-6282	307	4	chang	chang	PROPN
fnp-6282	307	5	cc	cc	PROPN
fnp-6282	307	6	,	,	PUNCT
fnp-6282	307	7	peng	peng	PROPN
fnp-6282	307	8	m	m	PROPN
fnp-6282	307	9	,	,	PUNCT
fnp-6282	307	10	chen	chen	PROPN
fnp-6282	307	11	ly	ly	PROPN
fnp-6282	307	12	,	,	PUNCT
fnp-6282	307	13	lin	lin	PROPN
fnp-6282	307	14	wc	wc	PROPN
fnp-6282	307	15	,	,	PUNCT
fnp-6282	307	16	pai	pai	PROPN
fnp-6282	307	17	lm	lm	PROPN
fnp-6282	307	18	,	,	PUNCT
fnp-6282	307	19	andrade	andrade	PROPN
fnp-6282	307	20	lec	lec	PROPN
fnp-6282	307	21	,	,	PUNCT
fnp-6282	307	22	sung	sing	VERB
fnp-6282	307	23	ly	ly	PROPN
fnp-6282	307	24	,	,	PUNCT
fnp-6282	307	25	liu	liu	PROPN
fnp-6282	307	26	jl	jl	PROPN
fnp-6282	307	27	(	(	PUNCT
fnp-6282	307	28	2018	2018	NUM
fnp-6282	307	29	)	)	PUNCT
fnp-6282	307	30	imp	imp	PROPN
fnp-6282	307	31	/	/	SYM
fnp-6282	307	32	gtp	gtp	NOUN
fnp-6282	307	33	balance	balance	NOUN
fnp-6282	307	34	modulates	modulate	VERB
fnp-6282	307	35	cytoophidium	cytoophidium	NOUN
fnp-6282	307	36	assembly	assembly	NOUN
fnp-6282	307	37	and	and	CCONJ
fnp-6282	307	38	impdh	impdh	NOUN
fnp-6282	307	39	activity	activity	NOUN
fnp-6282	307	40	.	.	PUNCT
fnp-6282	308	1	cell	cell	NOUN
fnp-6282	308	2	div	div	NOUN
fnp-6282	308	3	13	13	NUM
fnp-6282	308	4	:	:	SYM
fnp-6282	308	5	5	5	NUM
fnp-6282	308	6	.	.	X
fnp-6282	308	7	https://doi.org/10.1186/s13008-018-0038-0	https://doi.org/10.1186/s13008-018-0038-0	NUM
fnp-6282	308	8	34	34	NUM
fnp-6282	308	9	.	.	PUNCT
fnp-6282	309	1	kofuji	kofuji	PROPN
fnp-6282	309	2	s	s	PROPN
fnp-6282	309	3	,	,	PUNCT
fnp-6282	309	4	hirayama	hirayama	PROPN
fnp-6282	309	5	a	a	X
fnp-6282	309	6	,	,	PUNCT
fnp-6282	309	7	eberhardt	eberhardt	PROPN
fnp-6282	309	8	ao	ao	PROPN
fnp-6282	309	9	,	,	PUNCT
fnp-6282	309	10	kawaguchi	kawaguchi	PROPN
fnp-6282	309	11	r	r	PROPN
fnp-6282	309	12	,	,	PUNCT
fnp-6282	309	13	sugiura	sugiura	NOUN
fnp-6282	309	14	y	y	PROPN
fnp-6282	309	15	,	,	PUNCT
fnp-6282	309	16	sampetrean	sampetrean	ADJ
fnp-6282	309	17	o	o	NOUN
fnp-6282	309	18	,	,	PUNCT
fnp-6282	309	19	ikeda	ikeda	PROPN
fnp-6282	309	20	y	y	PROPN
fnp-6282	309	21	,	,	PUNCT
fnp-6282	309	22	warren	warren	PROPN
fnp-6282	309	23	m	m	PROPN
fnp-6282	309	24	,	,	PUNCT
fnp-6282	309	25	sakamoto	sakamoto	PROPN
fnp-6282	309	26	n	n	CCONJ
fnp-6282	309	27	,	,	PUNCT
fnp-6282	309	28	kitahara	kitahara	PROPN
fnp-6282	309	29	set	set	VERB
fnp-6282	309	30	al	al	PROPN
fnp-6282	309	31	(	(	PUNCT
fnp-6282	309	32	2019	2019	NUM
fnp-6282	309	33	)	)	PUNCT
fnp-6282	309	34	imp	imp	VERB
fnp-6282	309	35	dehydrogenase-2	dehydrogenase-2	PROPN
fnp-6282	309	36	drives	drive	NOUN
fnp-6282	309	37	aberrant	aberrant	ADJ
fnp-6282	309	38	nucleolar	nucleolar	ADJ
fnp-6282	309	39	activity	activity	NOUN
fnp-6282	309	40	and	and	CCONJ
fnp-6282	309	41	promotes	promote	VERB
fnp-6282	309	42	tumorigenesis	tumorigenesis	NOUN
fnp-6282	309	43	in	in	ADP
fnp-6282	309	44	glioblastoma	glioblastoma	NOUN
fnp-6282	309	45	.	.	PUNCT
fnp-6282	310	1	nat	nat	NOUN
fnp-6282	310	2	cell	cell	NOUN
fnp-6282	310	3	biol	biol	NOUN
fnp-6282	310	4	21	21	NUM
fnp-6282	310	5	:	:	PUNCT
fnp-6282	310	6	1003	1003	NUM
fnp-6282	310	7	-	-	SYM
fnp-6282	310	8	1014	1014	NUM
fnp-6282	310	9	.	.	PUNCT
fnp-6282	311	1	https://doi.org/10.1038/s41556-019-0363-9	https://doi.org/10.1038/s41556-019-0363-9	NUM
fnp-6282	311	2	35	35	NUM
fnp-6282	311	3	.	.	PUNCT
fnp-6282	312	1	kofuji	kofuji	PROPN
fnp-6282	312	2	s	s	PROPN
fnp-6282	312	3	,	,	PUNCT
fnp-6282	312	4	sasaki	sasaki	PROPN
fnp-6282	312	5	at	at	ADP
fnp-6282	312	6	(	(	PUNCT
fnp-6282	312	7	2020	2020	NUM
fnp-6282	312	8	)	)	PUNCT
fnp-6282	312	9	gtp	gtp	NOUN
fnp-6282	312	10	metabolic	metabolic	NOUN
fnp-6282	312	11	reprogramming	reprogramme	VERB
fnp-6282	312	12	by	by	ADP
fnp-6282	312	13	impdh2	impdh2	PROPN
fnp-6282	312	14	:	:	PUNCT
fnp-6282	312	15	unlocking	unlock	VERB
fnp-6282	312	16	cancer	cancer	NOUN
fnp-6282	312	17	cells	cell	NOUN
fnp-6282	312	18	'	'	PART
fnp-6282	312	19	fuelling	fuelling	NOUN
fnp-6282	312	20	mechanism	mechanism	NOUN
fnp-6282	312	21	.	.	PUNCT
fnp-6282	313	1	j	j	PROPN
fnp-6282	313	2	biochem	biochem	PROPN
fnp-6282	313	3	168	168	NUM
fnp-6282	313	4	:	:	PUNCT
fnp-6282	313	5	319	319	NUM
fnp-6282	313	6	-	-	SYM
fnp-6282	313	7	328	328	NUM
fnp-6282	313	8	.	.	PUNCT
fnp-6282	314	1	https://doi.org/10.1093/jb/mvaa085	https://doi.org/10.1093/jb/mvaa085	PROPN
fnp-6282	315	1	36	36	NUM
fnp-6282	315	2	.	.	PUNCT
fnp-6282	315	3	kovacs	kovacs	PROPN
fnp-6282	315	4	gg	gg	PROPN
fnp-6282	315	5	,	,	PUNCT
fnp-6282	315	6	lukic	lukic	PROPN
fnp-6282	315	7	mj	mj	PROPN
fnp-6282	315	8	,	,	PUNCT
fnp-6282	315	9	irwin	irwin	PROPN
fnp-6282	315	10	dj	dj	PROPN
fnp-6282	315	11	,	,	PUNCT
fnp-6282	315	12	arzberger	arzberger	PROPN
fnp-6282	315	13	t	t	PROPN
fnp-6282	315	14	,	,	PUNCT
fnp-6282	315	15	respondek	respondek	PROPN
fnp-6282	315	16	g	g	PROPN
fnp-6282	315	17	,	,	PUNCT
fnp-6282	315	18	lee	lee	PROPN
fnp-6282	315	19	eb	eb	PROPN
fnp-6282	315	20	,	,	PUNCT
fnp-6282	315	21	coughlin	coughlin	PROPN
fnp-6282	315	22	d	d	PROPN
fnp-6282	315	23	,	,	PUNCT
fnp-6282	315	24	giese	giese	ADJ
fnp-6282	315	25	a	a	PRON
fnp-6282	315	26	,	,	PUNCT
fnp-6282	315	27	grossman	grossman	PROPN
fnp-6282	315	28	m	m	PROPN
fnp-6282	315	29	,	,	PUNCT
fnp-6282	315	30	kurz	kurz	PROPN
fnp-6282	315	31	cet	cet	PROPN
fnp-6282	315	32	al	al	PROPN
fnp-6282	315	33	(	(	PUNCT
fnp-6282	315	34	2020	2020	NUM
fnp-6282	315	35	)	)	PUNCT
fnp-6282	315	36	distribution	distribution	NOUN
fnp-6282	315	37	patterns	pattern	NOUN
fnp-6282	315	38	of	of	ADP
fnp-6282	315	39	tau	tau	PROPN
fnp-6282	315	40	pathology	pathology	NOUN
fnp-6282	315	41	in	in	ADP
fnp-6282	315	42	progressive	progressive	ADJ
fnp-6282	315	43	supranuclear	supranuclear	ADJ
fnp-6282	315	44	palsy	palsy	ADJ
fnp-6282	315	45	.	.	PUNCT
fnp-6282	316	1	acta	acta	PROPN
fnp-6282	316	2	neuropathol	neuropathol	PROPN
fnp-6282	316	3	140	140	NUM
fnp-6282	316	4	:	:	PUNCT
fnp-6282	316	5	99	99	NUM
fnp-6282	316	6	-	-	SYM
fnp-6282	316	7	119	119	NUM
fnp-6282	316	8	.	.	PUNCT
fnp-6282	316	9	https://doi.org/10.1007/s00401-020-02158-2	https://doi.org/10.1007/s00401-020-02158-2	NUM
fnp-6282	316	10	37	37	NUM
fnp-6282	316	11	.	.	PUNCT
fnp-6282	317	1	kozhevnikova	kozhevnikova	PROPN
fnp-6282	317	2	en	en	PROPN
fnp-6282	317	3	,	,	PUNCT
fnp-6282	317	4	van	van	PROPN
fnp-6282	317	5	der	der	PROPN
fnp-6282	317	6	knaap	knaap	PROPN
fnp-6282	317	7	ja	ja	PROPN
fnp-6282	317	8	,	,	PUNCT
fnp-6282	317	9	pindyurin	pindyurin	NOUN
fnp-6282	317	10	av	av	PROPN
fnp-6282	317	11	,	,	PUNCT
fnp-6282	317	12	ozgur	ozgur	PROPN
fnp-6282	317	13	z	z	PROPN
fnp-6282	317	14	,	,	PUNCT
fnp-6282	317	15	van	van	PROPN
fnp-6282	317	16	ijcken	ijcken	VERB
fnp-6282	317	17	wf	wf	PROPN
fnp-6282	317	18	,	,	PUNCT
fnp-6282	317	19	moshkin	moshkin	PROPN
fnp-6282	317	20	ym	ym	PROPN
fnp-6282	317	21	,	,	PUNCT
fnp-6282	317	22	verrijzer	verrijzer	NOUN
fnp-6282	317	23	cp	cp	PROPN
fnp-6282	317	24	(	(	PUNCT
fnp-6282	317	25	2012	2012	NUM
fnp-6282	317	26	)	)	PUNCT
fnp-6282	317	27	metabolic	metabolic	NOUN
fnp-6282	317	28	enzyme	enzyme	NOUN
fnp-6282	317	29	impdh	impdh	NOUN
fnp-6282	317	30	is	be	AUX
fnp-6282	317	31	also	also	ADV
fnp-6282	317	32	a	a	DET
fnp-6282	317	33	transcription	transcription	NOUN
fnp-6282	317	34	factor	factor	NOUN
fnp-6282	317	35	regulated	regulate	VERB
fnp-6282	317	36	by	by	ADP
fnp-6282	317	37	cellular	cellular	ADJ
fnp-6282	317	38	state	state	NOUN
fnp-6282	317	39	.	.	PUNCT
fnp-6282	318	1	mol	mol	ADP
fnp-6282	318	2	cell	cell	NOUN
fnp-6282	318	3	47	47	NUM
fnp-6282	318	4	:	:	PUNCT
fnp-6282	318	5	133	133	NUM
fnp-6282	318	6	-	-	SYM
fnp-6282	318	7	139	139	NUM
fnp-6282	318	8	.	.	PUNCT
fnp-6282	319	1	https://doi.org/10.1016/j.molcel.2012.04.030	https://doi.org/10.1016/j.molcel.2012.04.030	PROPN
fnp-6282	319	2	38	38	NUM
fnp-6282	319	3	.	.	PUNCT
fnp-6282	320	1	kuukasjarvi	kuukasjarvi	PROPN
fnp-6282	320	2	a	a	DET
fnp-6282	320	3	,	,	PUNCT
fnp-6282	320	4	landoni	landoni	PROPN
fnp-6282	320	5	jc	jc	PROPN
fnp-6282	320	6	,	,	PUNCT
fnp-6282	320	7	kaukonen	kaukonen	PROPN
fnp-6282	320	8	j	j	PROPN
fnp-6282	320	9	,	,	PUNCT
fnp-6282	320	10	juhakoski	juhakoski	PROPN
fnp-6282	320	11	m	m	PROPN
fnp-6282	320	12	,	,	PUNCT
fnp-6282	320	13	auranen	auranen	PROPN
fnp-6282	320	14	m	m	PROPN
fnp-6282	320	15	,	,	PUNCT
fnp-6282	320	16	torkkeli	torkkeli	PROPN
fnp-6282	320	17	t	t	PROPN
fnp-6282	320	18	,	,	PUNCT
fnp-6282	320	19	velagapudi	velagapudi	PROPN
fnp-6282	320	20	v	v	NOUN
fnp-6282	320	21	,	,	PUNCT
fnp-6282	320	22	suomalainen	suomalainen	PROPN
fnp-6282	320	23	a	a	PRON
fnp-6282	320	24	(	(	PUNCT
fnp-6282	320	25	2021	2021	NUM
fnp-6282	320	26	)	)	PUNCT
fnp-6282	321	1	impdh2	impdh2	PROPN
fnp-6282	321	2	:	:	PUNCT
fnp-6282	321	3	a	a	DET
fnp-6282	321	4	new	new	ADJ
fnp-6282	321	5	gene	gene	NOUN
fnp-6282	321	6	associated	associate	VERB
fnp-6282	321	7	with	with	ADP
fnp-6282	321	8	dominant	dominant	ADJ
fnp-6282	321	9	juvenile	juvenile	ADJ
fnp-6282	321	10	-	-	PUNCT
fnp-6282	321	11	onset	onset	NOUN
fnp-6282	321	12	dystonia	dystonia	NOUN
fnp-6282	321	13	-	-	PUNCT
fnp-6282	321	14	tremor	tremor	NOUN
fnp-6282	321	15	disorder	disorder	NOUN
fnp-6282	321	16	.	.	PUNCT
fnp-6282	322	1	eur	eur	PROPN
fnp-6282	322	2	j	j	PROPN
fnp-6282	322	3	hum	hum	PROPN
fnp-6282	322	4	genet	genet	PROPN
fnp-6282	322	5	29	29	NUM
fnp-6282	322	6	:	:	PUNCT
fnp-6282	322	7	1833	1833	NUM
fnp-6282	322	8	-	-	SYM
fnp-6282	322	9	1837	1837	NUM
fnp-6282	322	10	.	.	PUNCT
fnp-6282	323	1	https://doi.org/10.1038/s41431-021-00939-1	https://doi.org/10.1038/s41431-021-00939-1	NUM
fnp-6282	323	2	39	39	NUM
fnp-6282	323	3	.	.	PUNCT
fnp-6282	324	1	lamba	lamba	PROPN
fnp-6282	324	2	w	w	PROPN
fnp-6282	324	3	,	,	PUNCT
fnp-6282	324	4	prichett	prichett	PROPN
fnp-6282	324	5	w	w	PROPN
fnp-6282	324	6	,	,	PUNCT
fnp-6282	324	7	munoz	munoz	PROPN
fnp-6282	324	8	d	d	PROPN
fnp-6282	324	9	,	,	PUNCT
fnp-6282	324	10	park	park	NOUN
fnp-6282	324	11	ds	ds	PROPN
fnp-6282	324	12	,	,	PUNCT
fnp-6282	324	13	woulfe	woulfe	VERB
fnp-6282	324	14	jm	jm	PROPN
fnp-6282	324	15	(	(	PUNCT
fnp-6282	324	16	2005	2005	NUM
fnp-6282	324	17	)	)	PUNCT
fnp-6282	324	18	mptp	mptp	PROPN
fnp-6282	324	19	induces	induce	VERB
fnp-6282	324	20	intranuclear	intranuclear	NOUN
fnp-6282	324	21	rodlet	rodlet	NOUN
fnp-6282	324	22	formation	formation	NOUN
fnp-6282	324	23	in	in	ADP
fnp-6282	324	24	midbrain	midbrain	NOUN
fnp-6282	324	25	dopaminergic	dopaminergic	ADJ
fnp-6282	324	26	neurons	neuron	NOUN
fnp-6282	324	27	.	.	PUNCT
fnp-6282	325	1	brain	brain	NOUN
fnp-6282	325	2	res	re	NOUN
fnp-6282	325	3	1066	1066	NUM
fnp-6282	325	4	:	:	PUNCT
fnp-6282	325	5	86	86	NUM
fnp-6282	325	6	-	-	SYM
fnp-6282	325	7	91	91	NUM
fnp-6282	325	8	.	.	PUNCT
fnp-6282	326	1	https://doi.org/10.1016/j.brainres.2005.10.058	https://doi.org/10.1016/j.brainres.2005.10.058	NUM
fnp-6282	326	2	40	40	NUM
fnp-6282	326	3	.	.	PUNCT
fnp-6282	327	1	liu	liu	PROPN
fnp-6282	327	2	jl	jl	PROPN
fnp-6282	327	3	(	(	PUNCT
fnp-6282	327	4	2016	2016	NUM
fnp-6282	327	5	)	)	PUNCT
fnp-6282	327	6	the	the	DET
fnp-6282	327	7	cytoophidium	cytoophidium	NOUN
fnp-6282	327	8	and	and	CCONJ
fnp-6282	327	9	its	its	PRON
fnp-6282	327	10	kind	kind	NOUN
fnp-6282	327	11	:	:	PUNCT
fnp-6282	327	12	filamentation	filamentation	NOUN
fnp-6282	327	13	and	and	CCONJ
fnp-6282	327	14	compartmentation	compartmentation	NOUN
fnp-6282	327	15	of	of	ADP
fnp-6282	327	16	metabolic	metabolic	NOUN
fnp-6282	327	17	enzymes	enzyme	NOUN
fnp-6282	327	18	.	.	PUNCT
fnp-6282	328	1	annu	annu	PROPN
fnp-6282	328	2	rev	rev	PROPN
fnp-6282	328	3	cell	cell	PROPN
fnp-6282	328	4	dev	dev	PROPN
fnp-6282	328	5	biol	biol	PROPN
fnp-6282	328	6	32	32	NUM
fnp-6282	328	7	:	:	PUNCT
fnp-6282	328	8	349	349	NUM
fnp-6282	328	9	-	-	SYM
fnp-6282	328	10	372	372	NUM
fnp-6282	328	11	.	.	PUNCT
fnp-6282	329	1	https://doi.org/10.1146/annurev-cellbio-111315-124907	https://doi.org/10.1146/annurev-cellbio-111315-124907	PROPN
fnp-6282	329	2	41	41	NUM
fnp-6282	329	3	.	.	PUNCT
fnp-6282	330	1	lynch	lynch	PROPN
fnp-6282	330	2	em	em	PRON
fnp-6282	330	3	,	,	PUNCT
fnp-6282	330	4	kollman	kollman	PROPN
fnp-6282	330	5	jm	jm	PROPN
fnp-6282	330	6	,	,	PUNCT
fnp-6282	330	7	webb	webb	PROPN
fnp-6282	330	8	ba	ba	PROPN
fnp-6282	330	9	(	(	PUNCT
fnp-6282	330	10	2020	2020	NUM
fnp-6282	330	11	)	)	PUNCT
fnp-6282	330	12	filament	filament	NOUN
fnp-6282	330	13	formation	formation	NOUN
fnp-6282	330	14	by	by	ADP
fnp-6282	330	15	metabolic	metabolic	NOUN
fnp-6282	330	16	enzymes	enzyme	NOUN
fnp-6282	330	17	-	-	PUNCT
fnp-6282	330	18	a	a	DET
fnp-6282	330	19	new	new	ADJ
fnp-6282	330	20	twist	twist	NOUN
fnp-6282	330	21	on	on	ADP
fnp-6282	330	22	regulation	regulation	NOUN
fnp-6282	330	23	.	.	PUNCT
fnp-6282	331	1	curr	curr	PROPN
fnp-6282	331	2	opin	opin	NOUN
fnp-6282	331	3	cell	cell	NOUN
fnp-6282	331	4	biol	biol	NOUN
fnp-6282	331	5	66	66	NUM
fnp-6282	331	6	:	:	PUNCT
fnp-6282	331	7	28	28	NUM
fnp-6282	331	8	-	-	SYM
fnp-6282	331	9	33	33	NUM
fnp-6282	331	10	.	.	PUNCT
fnp-6282	331	11	https://doi.org/10.1016/j.ceb.2020.04.006	https://doi.org/10.1016/j.ceb.2020.04.006	PROPN
fnp-6282	331	12	42	42	NUM
fnp-6282	331	13	.	.	PUNCT
fnp-6282	332	1	mercati	mercati	PROPN
fnp-6282	332	2	o	o	PROPN
fnp-6282	332	3	,	,	PUNCT
fnp-6282	332	4	abi	abi	PROPN
fnp-6282	332	5	warde	warde	PROPN
fnp-6282	332	6	mt	mt	PROPN
fnp-6282	332	7	,	,	PUNCT
fnp-6282	332	8	lina	lina	PROPN
fnp-6282	332	9	-	-	PUNCT
fnp-6282	332	10	granade	granade	PROPN
fnp-6282	332	11	g	g	PROPN
fnp-6282	332	12	,	,	PUNCT
fnp-6282	332	13	rio	rio	PROPN
fnp-6282	332	14	m	m	PROPN
fnp-6282	332	15	,	,	PUNCT
fnp-6282	332	16	heide	heide	PROPN
fnp-6282	332	17	s	s	PROPN
fnp-6282	332	18	,	,	PUNCT
fnp-6282	332	19	de	de	X
fnp-6282	332	20	lonlay	lonlay	NOUN
fnp-6282	332	21	p	p	NOUN
fnp-6282	332	22	,	,	PUNCT
fnp-6282	332	23	ceballos	ceballos	PROPN
fnp-6282	332	24	-	-	PUNCT
fnp-6282	332	25	picot	picot	PROPN
fnp-6282	332	26	i	i	PROPN
fnp-6282	332	27	,	,	PUNCT
fnp-6282	332	28	robert	robert	PROPN
fnp-6282	332	29	mp	mp	PROPN
fnp-6282	332	30	,	,	PUNCT
fnp-6282	332	31	couloigner	couloigner	ADJ
fnp-6282	332	32	v	v	NOUN
fnp-6282	332	33	,	,	PUNCT
fnp-6282	332	34	beltrand	beltrand	NOUN
fnp-6282	332	35	jet	jet	NOUN
fnp-6282	332	36	al	al	PROPN
fnp-6282	332	37	(	(	PUNCT
fnp-6282	332	38	2020	2020	NUM
fnp-6282	332	39	)	)	PUNCT
fnp-6282	332	40	prps1	prps1	NOUN
fnp-6282	332	41	loss	loss	NOUN
fnp-6282	332	42	-	-	PUNCT
fnp-6282	332	43	of	of	ADP
fnp-6282	332	44	-	-	PUNCT
fnp-6282	332	45	function	function	NOUN
fnp-6282	332	46	variants	variant	NOUN
fnp-6282	332	47	,	,	PUNCT
fnp-6282	332	48	from	from	ADP
fnp-6282	332	49	isolated	isolated	ADJ
fnp-6282	332	50	hearing	hearing	NOUN
fnp-6282	332	51	loss	loss	NOUN
fnp-6282	332	52	to	to	ADP
fnp-6282	332	53	severe	severe	ADJ
fnp-6282	332	54	congenital	congenital	ADJ
fnp-6282	332	55	encephalopathy	encephalopathy	NOUN
fnp-6282	332	56	:	:	PUNCT
fnp-6282	332	57	new	new	ADJ
fnp-6282	332	58	cases	case	NOUN
fnp-6282	332	59	and	and	CCONJ
fnp-6282	332	60	literature	literature	NOUN
fnp-6282	332	61	review	review	NOUN
fnp-6282	332	62	.	.	PUNCT
fnp-6282	333	1	eur	eur	PROPN
fnp-6282	333	2	j	j	PROPN
fnp-6282	333	3	med	med	PROPN
fnp-6282	333	4	genet	genet	PROPN
fnp-6282	333	5	63	63	NUM
fnp-6282	333	6	:	:	SYM
fnp-6282	333	7	104033	104033	NUM
fnp-6282	333	8	.	.	PUNCT
fnp-6282	334	1	https://doi.org/10.1016/j.ejmg.2020.104033	https://doi.org/10.1016/j.ejmg.2020.104033	PROPN
fnp-6282	334	2	43	43	NUM
fnp-6282	334	3	.	.	PUNCT
fnp-6282	335	1	metz	metz	PROPN
fnp-6282	335	2	sa	sa	PROPN
fnp-6282	335	3	,	,	PUNCT
fnp-6282	335	4	kowluru	kowluru	VERB
fnp-6282	335	5	a	a	DET
fnp-6282	335	6	(	(	PUNCT
fnp-6282	335	7	1999	1999	NUM
fnp-6282	335	8	)	)	PUNCT
fnp-6282	335	9	inosine	inosine	NOUN
fnp-6282	335	10	monophosphate	monophosphate	NOUN
fnp-6282	335	11	dehydrogenase	dehydrogenase	NOUN
fnp-6282	335	12	:	:	PUNCT
fnp-6282	335	13	a	a	DET
fnp-6282	335	14	molecular	molecular	ADJ
fnp-6282	335	15	switch	switch	NOUN
fnp-6282	335	16	integrating	integrate	VERB
fnp-6282	335	17	pleiotropic	pleiotropic	ADJ
fnp-6282	335	18	gtp	gtp	NOUN
fnp-6282	335	19	-	-	PUNCT
fnp-6282	335	20	dependent	dependent	ADJ
fnp-6282	335	21	beta	beta	NOUN
fnp-6282	335	22	-	-	PUNCT
fnp-6282	335	23	cell	cell	NOUN
fnp-6282	335	24	functions	function	NOUN
fnp-6282	335	25	.	.	PUNCT
fnp-6282	336	1	proc	proc	PROPN
fnp-6282	336	2	assoc	assoc	PROPN
fnp-6282	336	3	am	am	PROPN
fnp-6282	336	4	physicians	physician	NOUN
fnp-6282	336	5	111	111	NUM
fnp-6282	336	6	:	:	PUNCT
fnp-6282	336	7	335	335	NUM
fnp-6282	336	8	-	-	SYM
fnp-6282	336	9	346	346	NUM
fnp-6282	336	10	.	.	PUNCT
fnp-6282	337	1	https://doi.org/10.1046/j.1525-1381.1999.99245.x	https://doi.org/10.1046/j.1525-1381.1999.99245.x	NOUN
fnp-6282	337	2	44	44	NUM
fnp-6282	337	3	.	.	PUNCT
fnp-6282	338	1	milman	milman	PROPN
fnp-6282	338	2	p	p	PROPN
fnp-6282	338	3	,	,	PUNCT
fnp-6282	338	4	fu	fu	PROPN
fnp-6282	338	5	a	a	PRON
fnp-6282	338	6	,	,	PUNCT
fnp-6282	338	7	screaton	screaton	PROPN
fnp-6282	338	8	ra	ra	PROPN
fnp-6282	338	9	,	,	PUNCT
fnp-6282	338	10	woulfe	woulfe	VERB
fnp-6282	338	11	jm	jm	PROPN
fnp-6282	338	12	(	(	PUNCT
fnp-6282	338	13	2010	2010	NUM
fnp-6282	338	14	)	)	PUNCT
fnp-6282	338	15	depletion	depletion	NOUN
fnp-6282	338	16	of	of	ADP
fnp-6282	338	17	intranuclear	intranuclear	NOUN
fnp-6282	338	18	rodlets	rodlet	NOUN
fnp-6282	338	19	in	in	ADP
fnp-6282	338	20	mouse	mouse	NOUN
fnp-6282	338	21	models	model	NOUN
fnp-6282	338	22	of	of	ADP
fnp-6282	338	23	diabetes	diabetes	NOUN
fnp-6282	338	24	.	.	PUNCT
fnp-6282	339	1	endocrine	endocrine	ADJ
fnp-6282	339	2	pathology	pathology	NOUN
fnp-6282	339	3	21	21	NUM
fnp-6282	339	4	:	:	PUNCT
fnp-6282	339	5	230	230	NUM
fnp-6282	339	6	-	-	SYM
fnp-6282	339	7	235	235	NUM
fnp-6282	339	8	.	.	PUNCT
fnp-6282	340	1	https://doi.org/10.1007/s12022-010-9136-5	https://doi.org/10.1007/s12022-010-9136-5	NUM
fnp-6282	340	2	45	45	NUM
fnp-6282	340	3	.	.	PUNCT
fnp-6282	341	1	mirra	mirra	PROPN
fnp-6282	341	2	ss	ss	PROPN
fnp-6282	341	3	,	,	PUNCT
fnp-6282	341	4	heyman	heyman	PROPN
fnp-6282	341	5	a	a	PROPN
fnp-6282	341	6	,	,	PUNCT
fnp-6282	341	7	mckeel	mckeel	NOUN
fnp-6282	341	8	d	d	PROPN
fnp-6282	341	9	,	,	PUNCT
fnp-6282	341	10	sumi	sumi	NOUN
fnp-6282	341	11	sm	sm	PROPN
fnp-6282	341	12	,	,	PUNCT
fnp-6282	341	13	crain	crain	NOUN
fnp-6282	341	14	bj	bj	PROPN
fnp-6282	341	15	,	,	PUNCT
fnp-6282	341	16	brownlee	brownlee	PROPN
fnp-6282	341	17	lm	lm	PROPN
fnp-6282	341	18	,	,	PUNCT
fnp-6282	341	19	vogel	vogel	PROPN
fnp-6282	341	20	fs	fs	PROPN
fnp-6282	341	21	,	,	PUNCT
fnp-6282	341	22	hughes	hughes	PROPN
fnp-6282	341	23	jp	jp	PROPN
fnp-6282	341	24	,	,	PUNCT
fnp-6282	341	25	van	van	PROPN
fnp-6282	341	26	belle	belle	PROPN
fnp-6282	341	27	g	g	PROPN
fnp-6282	341	28	,	,	PUNCT
fnp-6282	341	29	berg	berg	PROPN
fnp-6282	341	30	l	l	PROPN
fnp-6282	341	31	(	(	PUNCT
fnp-6282	341	32	1991	1991	NUM
fnp-6282	341	33	)	)	PUNCT
fnp-6282	341	34	the	the	DET
fnp-6282	341	35	consortium	consortium	NOUN
fnp-6282	341	36	to	to	PART
fnp-6282	341	37	establish	establish	VERB
fnp-6282	341	38	a	a	DET
fnp-6282	341	39	registry	registry	NOUN
fnp-6282	341	40	for	for	ADP
fnp-6282	341	41	alzheimer	alzheimer	PROPN
fnp-6282	341	42	's	's	PART
fnp-6282	341	43	disease	disease	NOUN
fnp-6282	341	44	(	(	PUNCT
fnp-6282	341	45	cerad	cerad	PROPN
fnp-6282	341	46	)	)	PUNCT
fnp-6282	341	47	.	.	PUNCT
fnp-6282	342	1	part	part	PROPN
fnp-6282	342	2	ii	ii	PROPN
fnp-6282	342	3	.	.	PUNCT
fnp-6282	343	1	standardization	standardization	NOUN
fnp-6282	343	2	of	of	ADP
fnp-6282	343	3	the	the	DET
fnp-6282	343	4	neuropathologic	neuropathologic	ADJ
fnp-6282	343	5	assessment	assessment	NOUN
fnp-6282	343	6	of	of	ADP
fnp-6282	343	7	alzheimer	alzheimer	PROPN
fnp-6282	343	8	's	's	PART
fnp-6282	343	9	disease	disease	NOUN
fnp-6282	343	10	.	.	PUNCT
fnp-6282	344	1	neurology	neurology	NOUN
fnp-6282	344	2	41	41	NUM
fnp-6282	344	3	:	:	PUNCT
fnp-6282	344	4	479	479	NUM
fnp-6282	344	5	-	-	SYM
fnp-6282	344	6	486	486	NUM
fnp-6282	344	7	.	.	PUNCT
fnp-6282	345	1	https://doi.org/10.1212/wnl.41.4.479	https://doi.org/10.1212/wnl.41.4.479	PROPN
fnp-6282	345	2	46	46	NUM
fnp-6282	345	3	.	.	PUNCT
fnp-6282	346	1	mittal	mittal	PROPN
fnp-6282	346	2	k	k	PROPN
fnp-6282	346	3	,	,	PUNCT
fnp-6282	346	4	katare	katare	VERB
fnp-6282	346	5	dp	dp	PROPN
fnp-6282	346	6	(	(	PUNCT
fnp-6282	346	7	2016	2016	NUM
fnp-6282	346	8	)	)	PUNCT
fnp-6282	346	9	shared	share	VERB
fnp-6282	346	10	links	link	NOUN
fnp-6282	346	11	between	between	ADP
fnp-6282	346	12	type	type	NOUN
fnp-6282	346	13	2	2	NUM
fnp-6282	346	14	diabetes	diabetes	NOUN
fnp-6282	346	15	mellitus	mellitus	NOUN
fnp-6282	346	16	and	and	CCONJ
fnp-6282	346	17	alzheimer	alzheimer	PROPN
fnp-6282	346	18	's	's	PART
fnp-6282	346	19	disease	disease	NOUN
fnp-6282	346	20	:	:	PUNCT
fnp-6282	346	21	a	a	DET
fnp-6282	346	22	review	review	NOUN
fnp-6282	346	23	.	.	PUNCT
fnp-6282	347	1	diabetes	diabete	VERB
fnp-6282	347	2	metab	metab	NOUN
fnp-6282	347	3	syndr	syndr	NOUN
fnp-6282	347	4	10	10	NUM
fnp-6282	347	5	:	:	PUNCT
fnp-6282	347	6	s144	s144	PROPN
fnp-6282	347	7	-	-	SYM
fnp-6282	347	8	149	149	NUM
fnp-6282	347	9	.	.	PUNCT
fnp-6282	348	1	https://doi.org/10.1016/j.dsx.2016.01.021	https://doi.org/10.1016/j.dsx.2016.01.021	PROPN
fnp-6282	348	2	47	47	NUM
fnp-6282	348	3	.	.	PUNCT
fnp-6282	349	1	montine	montine	PROPN
fnp-6282	349	2	tj	tj	PROPN
fnp-6282	349	3	,	,	PUNCT
fnp-6282	349	4	phelps	phelps	PROPN
fnp-6282	349	5	ch	ch	PROPN
fnp-6282	349	6	,	,	PUNCT
fnp-6282	349	7	beach	beach	PROPN
fnp-6282	349	8	tg	tg	PROPN
fnp-6282	349	9	,	,	PUNCT
fnp-6282	349	10	bigio	bigio	NOUN
fnp-6282	349	11	eh	eh	INTJ
fnp-6282	349	12	,	,	PUNCT
fnp-6282	349	13	cairns	cairns	PROPN
fnp-6282	349	14	nj	nj	PROPN
fnp-6282	349	15	,	,	PUNCT
fnp-6282	349	16	dickson	dickson	PROPN
fnp-6282	349	17	dw	dw	PROPN
fnp-6282	349	18	,	,	PUNCT
fnp-6282	349	19	duyckaerts	duyckaerts	PROPN
fnp-6282	349	20	c	c	PROPN
fnp-6282	349	21	,	,	PUNCT
fnp-6282	349	22	frosch	frosch	PROPN
fnp-6282	349	23	mp	mp	PROPN
fnp-6282	349	24	,	,	PUNCT
fnp-6282	349	25	masliah	masliah	PROPN
fnp-6282	349	26	e	e	PROPN
fnp-6282	349	27	,	,	PUNCT
fnp-6282	349	28	mirra	mirra	NOUN
fnp-6282	349	29	sset	sset	VERB
fnp-6282	349	30	al	al	PROPN
fnp-6282	349	31	(	(	PUNCT
fnp-6282	349	32	2012	2012	NUM
fnp-6282	349	33	)	)	PUNCT
fnp-6282	349	34	national	national	PROPN
fnp-6282	349	35	institute	institute	NOUN
fnp-6282	349	36	on	on	ADP
fnp-6282	349	37	aging	age	VERB
fnp-6282	349	38	-	-	PUNCT
fnp-6282	349	39	alzheimer	alzheimer	NOUN
fnp-6282	349	40	's	's	PART
fnp-6282	349	41	association	association	NOUN
fnp-6282	349	42	guidelines	guideline	NOUN
fnp-6282	349	43	for	for	ADP
fnp-6282	349	44	the	the	DET
fnp-6282	349	45	neuropathologic	neuropathologic	ADJ
fnp-6282	349	46	assessment	assessment	NOUN
fnp-6282	349	47	of	of	ADP
fnp-6282	349	48	alzheimer	alzheimer	PROPN
fnp-6282	349	49	's	's	PART
fnp-6282	349	50	disease	disease	NOUN
fnp-6282	349	51	:	:	PUNCT
fnp-6282	349	52	a	a	DET
fnp-6282	349	53	practical	practical	ADJ
fnp-6282	349	54	approach	approach	NOUN
fnp-6282	349	55	.	.	PUNCT
fnp-6282	350	1	acta	acta	PROPN
fnp-6282	350	2	neuropathol	neuropathol	PROPN
fnp-6282	350	3	123	123	NUM
fnp-6282	350	4	:	:	PUNCT
fnp-6282	350	5	1	1	NUM
fnp-6282	350	6	-	-	SYM
fnp-6282	350	7	11	11	NUM
fnp-6282	350	8	.	.	PUNCT
fnp-6282	350	9	https://doi.org/10.1007/s00401-011-0910-3	https://doi.org/10.1007/s00401-011-0910-3	NOUN
fnp-6282	350	10	48	48	NUM
fnp-6282	350	11	.	.	PUNCT
fnp-6282	351	1	natsumeda	natsumeda	PROPN
fnp-6282	351	2	y	y	PROPN
fnp-6282	351	3	,	,	PUNCT
fnp-6282	351	4	ohno	ohno	PROPN
fnp-6282	351	5	s	s	PROPN
fnp-6282	351	6	,	,	PUNCT
fnp-6282	351	7	kawasaki	kawasaki	PROPN
fnp-6282	351	8	h	h	PROPN
fnp-6282	351	9	,	,	PUNCT
fnp-6282	351	10	konno	konno	PROPN
fnp-6282	351	11	y	y	PROPN
fnp-6282	351	12	,	,	PUNCT
fnp-6282	351	13	weber	weber	PROPN
fnp-6282	351	14	g	g	PROPN
fnp-6282	351	15	,	,	PUNCT
fnp-6282	351	16	suzuki	suzuki	PROPN
fnp-6282	351	17	k	k	PROPN
fnp-6282	351	18	(	(	PUNCT
fnp-6282	351	19	1990	1990	NUM
fnp-6282	351	20	)	)	PUNCT
fnp-6282	351	21	two	two	NUM
fnp-6282	351	22	distinct	distinct	ADJ
fnp-6282	351	23	cdnas	cdna	NOUN
fnp-6282	351	24	for	for	ADP
fnp-6282	351	25	human	human	ADJ
fnp-6282	351	26	imp	imp	PROPN
fnp-6282	351	27	dehydrogenase	dehydrogenase	NOUN
fnp-6282	351	28	.	.	PUNCT
fnp-6282	352	1	j	j	PROPN
fnp-6282	352	2	biol	biol	PROPN
fnp-6282	352	3	chem	chem	NOUN
fnp-6282	352	4	265	265	NUM
fnp-6282	352	5	:	:	PUNCT
fnp-6282	352	6	5292	5292	NUM
fnp-6282	352	7	-	-	SYM
fnp-6282	352	8	5295	5295	NUM
fnp-6282	352	9	.	.	PUNCT
fnp-6282	353	1	https://doi.org/10.1016/s0021-9258(19)34120-1	https://doi.org/10.1016/s0021-9258(19)34120-1	PROPN
fnp-6282	353	2	49	49	NUM
fnp-6282	353	3	.	.	PUNCT
fnp-6282	354	1	neary	neary	PROPN
fnp-6282	354	2	jt	jt	PROPN
fnp-6282	354	3	,	,	PUNCT
fnp-6282	354	4	rathbone	rathbone	PROPN
fnp-6282	354	5	mp	mp	PROPN
fnp-6282	354	6	,	,	PUNCT
fnp-6282	354	7	cattabeni	cattabeni	PROPN
fnp-6282	354	8	f	f	PROPN
fnp-6282	354	9	,	,	PUNCT
fnp-6282	354	10	abbracchio	abbracchio	PROPN
fnp-6282	354	11	mp	mp	PROPN
fnp-6282	354	12	,	,	PUNCT
fnp-6282	354	13	burnstock	burnstock	NOUN
fnp-6282	354	14	g	g	PROPN
fnp-6282	354	15	(	(	PUNCT
fnp-6282	354	16	1996	1996	NUM
fnp-6282	354	17	)	)	PUNCT
fnp-6282	354	18	trophic	trophic	ADJ
fnp-6282	354	19	actions	action	NOUN
fnp-6282	354	20	of	of	ADP
fnp-6282	354	21	extracellular	extracellular	ADJ
fnp-6282	354	22	nucleotides	nucleotide	NOUN
fnp-6282	354	23	and	and	CCONJ
fnp-6282	354	24	nucleosides	nucleoside	NOUN
fnp-6282	354	25	on	on	ADP
fnp-6282	354	26	glial	glial	ADJ
fnp-6282	354	27	and	and	CCONJ
fnp-6282	354	28	neuronal	neuronal	ADJ
fnp-6282	354	29	cells	cell	NOUN
fnp-6282	354	30	.	.	PUNCT
fnp-6282	355	1	trends	trend	NOUN
fnp-6282	355	2	neurosci	neurosci	VERB
fnp-6282	355	3	19	19	NUM
fnp-6282	355	4	:	:	SYM
fnp-6282	355	5	13	13	NUM
fnp-6282	355	6	-	-	SYM
fnp-6282	355	7	18	18	NUM
fnp-6282	355	8	.	.	PUNCT
fnp-6282	356	1	https://doi.org/10.1016/0166-2236(96)81861-3	https://doi.org/10.1016/0166-2236(96)81861-3	PROPN
fnp-6282	356	2	50	50	NUM
fnp-6282	356	3	.	.	PUNCT
fnp-6282	357	1	noree	noree	PROPN
fnp-6282	357	2	c	c	PROPN
fnp-6282	357	3	,	,	PUNCT
fnp-6282	357	4	begovich	begovich	PROPN
fnp-6282	357	5	k	k	PROPN
fnp-6282	357	6	,	,	PUNCT
fnp-6282	357	7	samilo	samilo	ADV
fnp-6282	357	8	d	d	NOUN
fnp-6282	357	9	,	,	PUNCT
fnp-6282	357	10	broyer	broyer	ADJ
fnp-6282	357	11	r	r	NOUN
fnp-6282	357	12	,	,	PUNCT
fnp-6282	357	13	monfort	monfort	NOUN
fnp-6282	357	14	e	e	PROPN
fnp-6282	357	15	,	,	PUNCT
fnp-6282	357	16	wilhelm	wilhelm	PROPN
fnp-6282	357	17	je	je	PROPN
fnp-6282	357	18	(	(	PUNCT
fnp-6282	357	19	2019	2019	NUM
fnp-6282	357	20	)	)	PUNCT
fnp-6282	357	21	a	a	DET
fnp-6282	357	22	quantitative	quantitative	ADJ
fnp-6282	357	23	screen	screen	NOUN
fnp-6282	357	24	for	for	ADP
fnp-6282	357	25	metabolic	metabolic	NOUN
fnp-6282	357	26	enzyme	enzyme	NOUN
fnp-6282	357	27	structures	structure	NOUN
fnp-6282	357	28	reveals	reveal	VERB
fnp-6282	357	29	patterns	pattern	NOUN
fnp-6282	357	30	of	of	ADP
fnp-6282	357	31	assembly	assembly	NOUN
fnp-6282	357	32	across	across	ADP
fnp-6282	357	33	the	the	DET
fnp-6282	357	34	yeast	yeast	NOUN
fnp-6282	357	35	metabolic	metabolic	NOUN
fnp-6282	357	36	network	network	NOUN
fnp-6282	357	37	.	.	PUNCT
fnp-6282	358	1	mol	mol	ADP
fnp-6282	358	2	biol	biol	PROPN
fnp-6282	358	3	cell	cell	NOUN
fnp-6282	358	4	30	30	NUM
fnp-6282	358	5	:	:	PUNCT
fnp-6282	358	6	2721	2721	NUM
fnp-6282	358	7	-	-	SYM
fnp-6282	358	8	2736	2736	NUM
fnp-6282	358	9	.	.	PUNCT
fnp-6282	358	10	https://doi.org/10.1091/mbc.e19-04-0224	https://doi.org/10.1091/mbc.e19-04-0224	X
fnp-6282	359	1	51	51	NUM
fnp-6282	359	2	.	.	PUNCT
fnp-6282	360	1	o'neill	o'neill	PROPN
fnp-6282	360	2	ag	ag	PROPN
fnp-6282	360	3	,	,	PUNCT
fnp-6282	360	4	burrell	burrell	PROPN
fnp-6282	360	5	al	al	PROPN
fnp-6282	360	6	,	,	PUNCT
fnp-6282	360	7	zech	zech	PROPN
fnp-6282	360	8	m	m	PROPN
fnp-6282	360	9	,	,	PUNCT
fnp-6282	360	10	elpeleg	elpeleg	PROPN
fnp-6282	360	11	o	o	NOUN
fnp-6282	360	12	,	,	PUNCT
fnp-6282	360	13	harel	harel	PROPN
fnp-6282	360	14	t	t	PROPN
fnp-6282	360	15	,	,	PUNCT
fnp-6282	360	16	edvardson	edvardson	PROPN
fnp-6282	360	17	s	s	PART
fnp-6282	360	18	,	,	PUNCT
fnp-6282	360	19	mor	mor	ADV
fnp-6282	360	20	-	-	PUNCT
fnp-6282	360	21	shaked	shake	VERB
fnp-6282	360	22	h	h	NOUN
fnp-6282	360	23	,	,	PUNCT
fnp-6282	360	24	rippert	rippert	PROPN
fnp-6282	360	25	al	al	PROPN
fnp-6282	360	26	,	,	PUNCT
fnp-6282	360	27	nomakuchi	nomakuchi	PROPN
fnp-6282	360	28	t	t	PROPN
fnp-6282	360	29	,	,	PUNCT
fnp-6282	360	30	izumi	izumi	PROPN
fnp-6282	360	31	ket	ket	PROPN
fnp-6282	360	32	al	al	PROPN
fnp-6282	360	33	(	(	PUNCT
fnp-6282	360	34	2023	2023	NUM
fnp-6282	360	35	)	)	PUNCT
fnp-6282	360	36	neurodevelopmental	neurodevelopmental	ADJ
fnp-6282	360	37	disorder	disorder	NOUN
fnp-6282	360	38	mutations	mutation	NOUN
fnp-6282	360	39	in	in	ADP
fnp-6282	360	40	the	the	DET
fnp-6282	360	41	purine	purine	NOUN
fnp-6282	360	42	biosynthetic	biosynthetic	ADJ
fnp-6282	360	43	enzyme	enzyme	NOUN
fnp-6282	360	44	impdh2	impdh2	NOUN
fnp-6282	360	45	disrupt	disrupt	VERB
fnp-6282	360	46	its	its	PRON
fnp-6282	360	47	allosteric	allosteric	ADJ
fnp-6282	360	48	regulation	regulation	NOUN
fnp-6282	360	49	.	.	PUNCT
fnp-6282	361	1	j	j	PROPN
fnp-6282	361	2	biol	biol	PROPN
fnp-6282	361	3	chem	chem	NOUN
fnp-6282	361	4	299	299	NUM
fnp-6282	361	5	:	:	PUNCT
fnp-6282	361	6	105012	105012	NUM
fnp-6282	361	7	.	.	PUNCT
fnp-6282	362	1	https://doi.org/10.1016/j.jbc.2023.105012	https://doi.org/10.1016/j.jbc.2023.105012	PROPN
fnp-6282	362	2	52	52	NUM
fnp-6282	362	3	.	.	PUNCT
fnp-6282	363	1	o'neill	o'neill	PROPN
fnp-6282	363	2	ag	ag	PROPN
fnp-6282	363	3	,	,	PUNCT
fnp-6282	363	4	burrell	burrell	PROPN
fnp-6282	363	5	al	al	PROPN
fnp-6282	363	6	,	,	PUNCT
fnp-6282	363	7	zech	zech	PROPN
fnp-6282	363	8	m	m	PROPN
fnp-6282	363	9	,	,	PUNCT
fnp-6282	363	10	elpeleg	elpeleg	PROPN
fnp-6282	363	11	o	o	NOUN
fnp-6282	363	12	,	,	PUNCT
fnp-6282	363	13	harel	harel	PROPN
fnp-6282	363	14	t	t	PROPN
fnp-6282	363	15	,	,	PUNCT
fnp-6282	363	16	edvardson	edvardson	PROPN
fnp-6282	363	17	s	s	PART
fnp-6282	363	18	,	,	PUNCT
fnp-6282	363	19	shaked	shaked	ADJ
fnp-6282	363	20	hm	hm	INTJ
fnp-6282	363	21	,	,	PUNCT
fnp-6282	363	22	rippert	rippert	PROPN
fnp-6282	363	23	al	al	PROPN
fnp-6282	363	24	,	,	PUNCT
fnp-6282	363	25	nomakuchi	nomakuchi	PROPN
fnp-6282	363	26	t	t	PROPN
fnp-6282	363	27	,	,	PUNCT
fnp-6282	363	28	izumi	izumi	PROPN
fnp-6282	363	29	ket	ket	PROPN
fnp-6282	363	30	al	al	PROPN
fnp-6282	363	31	(	(	PUNCT
fnp-6282	363	32	2023	2023	NUM
fnp-6282	363	33	)	)	PUNCT
fnp-6282	363	34	point	point	NOUN
fnp-6282	363	35	mutations	mutation	NOUN
fnp-6282	363	36	in	in	ADP
fnp-6282	363	37	impdh2	impdh2	NOUN
fnp-6282	363	38	which	which	PRON
fnp-6282	363	39	cause	cause	VERB
fnp-6282	363	40	early	early	ADJ
fnp-6282	363	41	-	-	PUNCT
fnp-6282	363	42	onset	onset	NOUN
fnp-6282	363	43	neurodevelopmental	neurodevelopmental	ADJ
fnp-6282	363	44	disorders	disorder	NOUN
fnp-6282	363	45	disrupt	disrupt	VERB
fnp-6282	363	46	enzyme	enzyme	NOUN
fnp-6282	363	47	regulation	regulation	NOUN
fnp-6282	363	48	and	and	CCONJ
fnp-6282	363	49	filament	filament	NOUN
fnp-6282	363	50	structure	structure	NOUN
fnp-6282	363	51	.	.	PUNCT
fnp-6282	364	1	biorxiv	biorxiv	NOUN
fnp-6282	364	2	:	:	PUNCT
fnp-6282	364	3	.	.	PUNCT
fnp-6282	365	1	https://doi.org/10.1101/2023.03.15.532669	https://doi.org/10.1101/2023.03.15.532669	NOUN
fnp-6282	365	2	53	53	NUM
fnp-6282	365	3	.	.	PUNCT
fnp-6282	366	1	pareek	pareek	PROPN
fnp-6282	366	2	v	v	PROPN
fnp-6282	366	3	,	,	PUNCT
fnp-6282	366	4	tian	tian	ADJ
fnp-6282	366	5	h	h	NOUN
fnp-6282	366	6	,	,	PUNCT
fnp-6282	366	7	winograd	winograd	PROPN
fnp-6282	366	8	n	n	PROPN
fnp-6282	366	9	,	,	PUNCT
fnp-6282	366	10	benkovic	benkovic	VERB
fnp-6282	366	11	sj	sj	INTJ
fnp-6282	366	12	(	(	PUNCT
fnp-6282	366	13	2020	2020	NUM
fnp-6282	366	14	)	)	PUNCT
fnp-6282	366	15	metabolomics	metabolomic	NOUN
fnp-6282	366	16	and	and	CCONJ
fnp-6282	366	17	mass	mass	ADJ
fnp-6282	366	18	spectrometry	spectrometry	NOUN
fnp-6282	366	19	imaging	imaging	NOUN
fnp-6282	366	20	reveal	reveal	VERB
fnp-6282	366	21	channeled	channel	VERB
fnp-6282	366	22	de	de	ADV
fnp-6282	366	23	novo	novo	NOUN
fnp-6282	366	24	purine	purine	NOUN
fnp-6282	366	25	synthesis	synthesis	NOUN
fnp-6282	366	26	in	in	ADP
fnp-6282	366	27	cells	cell	NOUN
fnp-6282	366	28	.	.	PUNCT
fnp-6282	367	1	science	science	NOUN
fnp-6282	367	2	368	368	NUM
fnp-6282	367	3	:	:	PUNCT
fnp-6282	367	4	283	283	NUM
fnp-6282	367	5	-	-	SYM
fnp-6282	367	6	290	290	NUM
fnp-6282	367	7	.	.	PUNCT
fnp-6282	368	1	https://doi.org/10.1126/science.aaz6465	https://doi.org/10.1126/science.aaz6465	PROPN
fnp-6282	368	2	54	54	NUM
fnp-6282	368	3	.	.	PUNCT
fnp-6282	369	1	pedley	pedley	PROPN
fnp-6282	369	2	am	be	AUX
fnp-6282	369	3	,	,	PUNCT
fnp-6282	369	4	pareek	pareek	ADJ
fnp-6282	369	5	v	v	NOUN
fnp-6282	369	6	,	,	PUNCT
fnp-6282	369	7	benkovic	benkovic	ADJ
fnp-6282	369	8	sj	sj	INTJ
fnp-6282	369	9	(	(	PUNCT
fnp-6282	369	10	2022	2022	NUM
fnp-6282	369	11	)	)	PUNCT
fnp-6282	369	12	the	the	DET
fnp-6282	369	13	purinosome	purinosome	NOUN
fnp-6282	369	14	:	:	PUNCT
fnp-6282	369	15	a	a	DET
fnp-6282	369	16	case	case	NOUN
fnp-6282	369	17	study	study	NOUN
fnp-6282	369	18	for	for	ADP
fnp-6282	369	19	a	a	DET
fnp-6282	369	20	mammalian	mammalian	ADJ
fnp-6282	369	21	metabolon	metabolon	NOUN
fnp-6282	369	22	.	.	PUNCT
fnp-6282	370	1	annu	annu	PROPN
fnp-6282	370	2	rev	rev	VERB
fnp-6282	370	3	biochem	biochem	PROPN
fnp-6282	370	4	91	91	NUM
fnp-6282	370	5	:	:	SYM
fnp-6282	370	6	89	89	NUM
fnp-6282	370	7	-	-	SYM
fnp-6282	370	8	106	106	NUM
fnp-6282	370	9	.	.	PUNCT
fnp-6282	371	1	https://doi.org/10.1146/annurev-biochem-032620-105728	https://doi.org/10.1146/annurev-biochem-032620-105728	PROPN
fnp-6282	371	2	55	55	NUM
fnp-6282	371	3	.	.	PUNCT
fnp-6282	372	1	prichett	prichett	PROPN
fnp-6282	372	2	w	w	PROPN
fnp-6282	372	3	,	,	PUNCT
fnp-6282	372	4	milman	milman	NOUN
fnp-6282	372	5	p	p	NOUN
fnp-6282	372	6	,	,	PUNCT
fnp-6282	372	7	gagnon	gagnon	PROPN
fnp-6282	372	8	j	j	PROPN
fnp-6282	372	9	,	,	PUNCT
fnp-6282	372	10	munoz	munoz	PROPN
fnp-6282	372	11	dg	dg	PROPN
fnp-6282	372	12	,	,	PUNCT
fnp-6282	372	13	woulfe	woulfe	VERB
fnp-6282	372	14	j	j	PROPN
fnp-6282	372	15	(	(	PUNCT
fnp-6282	372	16	2007	2007	NUM
fnp-6282	372	17	)	)	PUNCT
fnp-6282	372	18	intranuclear	intranuclear	NOUN
fnp-6282	372	19	rodlets	rodlet	NOUN
fnp-6282	372	20	in	in	ADP
fnp-6282	372	21	human	human	ADJ
fnp-6282	372	22	pancreatic	pancreatic	ADJ
fnp-6282	372	23	islet	islet	NOUN
fnp-6282	372	24	cells	cell	NOUN
fnp-6282	372	25	.	.	PUNCT
fnp-6282	373	1	pancreas	pancreas	NOUN
fnp-6282	373	2	35	35	NUM
fnp-6282	373	3	:	:	PUNCT
fnp-6282	373	4	207	207	NUM
fnp-6282	373	5	-	-	SYM
fnp-6282	373	6	211	211	NUM
fnp-6282	373	7	.	.	PUNCT
fnp-6282	374	1	https://doi.org/10.1097/mpa.0b013e318067fee1	https://doi.org/10.1097/mpa.0b013e318067fee1	PROPN
fnp-6282	374	2	56	56	NUM
fnp-6282	374	3	.	.	PUNCT
fnp-6282	375	1	reddy	reddy	PROPN
fnp-6282	375	2	ba	ba	PROPN
fnp-6282	375	3	,	,	PUNCT
fnp-6282	375	4	van	van	PROPN
fnp-6282	375	5	der	der	PROPN
fnp-6282	375	6	knaap	knaap	PROPN
fnp-6282	375	7	ja	ja	PROPN
fnp-6282	375	8	,	,	PUNCT
fnp-6282	375	9	bot	bot	PROPN
fnp-6282	375	10	ag	ag	PROPN
fnp-6282	375	11	,	,	PUNCT
fnp-6282	375	12	mohd	mohd	NOUN
fnp-6282	375	13	-	-	PUNCT
fnp-6282	375	14	sarip	sarip	NOUN
fnp-6282	375	15	a	a	PRON
fnp-6282	375	16	,	,	PUNCT
fnp-6282	375	17	dekkers	dekkers	PROPN
fnp-6282	375	18	dh	dh	PROPN
fnp-6282	375	19	,	,	PUNCT
fnp-6282	375	20	timmermans	timmermans	PROPN
fnp-6282	375	21	ma	ma	PROPN
fnp-6282	375	22	,	,	PUNCT
fnp-6282	375	23	martens	martens	PROPN
fnp-6282	375	24	jw	jw	PROPN
fnp-6282	375	25	,	,	PUNCT
fnp-6282	375	26	demmers	demmer	VERB
fnp-6282	375	27	ja	ja	PROPN
fnp-6282	375	28	,	,	PUNCT
fnp-6282	375	29	verrijzer	verrijzer	NOUN
fnp-6282	375	30	cp	cp	PROPN
fnp-6282	375	31	(	(	PUNCT
fnp-6282	375	32	2014	2014	NUM
fnp-6282	375	33	)	)	PUNCT
fnp-6282	375	34	nucleotide	nucleotide	NOUN
fnp-6282	375	35	biosynthetic	biosynthetic	ADJ
fnp-6282	375	36	enzyme	enzyme	NOUN
fnp-6282	375	37	gmp	gmp	NOUN
fnp-6282	375	38	synthase	synthase	NOUN
fnp-6282	375	39	is	be	AUX
fnp-6282	375	40	a	a	DET
fnp-6282	375	41	trim21	trim21	NOUN
fnp-6282	375	42	-	-	PUNCT
fnp-6282	375	43	controlled	control	VERB
fnp-6282	375	44	relay	relay	NOUN
fnp-6282	375	45	of	of	ADP
fnp-6282	375	46	p53	p53	NOUN
fnp-6282	375	47	stabilization	stabilization	NOUN
fnp-6282	375	48	.	.	PUNCT
fnp-6282	376	1	mol	mol	ADP
fnp-6282	376	2	cell	cell	NOUN
fnp-6282	376	3	53	53	NUM
fnp-6282	376	4	:	:	PUNCT
fnp-6282	376	5	458	458	NUM
fnp-6282	376	6	-	-	SYM
fnp-6282	376	7	470	470	NUM
fnp-6282	376	8	.	.	PUNCT
fnp-6282	377	1	https://doi.org/10.1016/j.molcel.2013.12.017	https://doi.org/10.1016/j.molcel.2013.12.017	NUM
fnp-6282	377	2	57	57	NUM
fnp-6282	377	3	.	.	PUNCT
fnp-6282	378	1	schneiter	schneiter	NOUN
fnp-6282	378	2	r	r	PROPN
fnp-6282	378	3	,	,	PUNCT
fnp-6282	378	4	carter	carter	PROPN
fnp-6282	378	5	at	at	ADP
fnp-6282	378	6	,	,	PUNCT
fnp-6282	378	7	hernando	hernando	PROPN
fnp-6282	378	8	y	y	PROPN
fnp-6282	378	9	,	,	PUNCT
fnp-6282	378	10	zellnig	zellnig	ADV
fnp-6282	378	11	g	g	PROPN
fnp-6282	378	12	,	,	PUNCT
fnp-6282	378	13	schweizer	schweizer	PROPN
fnp-6282	378	14	lm	lm	PROPN
fnp-6282	378	15	,	,	PUNCT
fnp-6282	378	16	schweizer	schweizer	PROPN
fnp-6282	378	17	m	m	PROPN
fnp-6282	378	18	(	(	PUNCT
fnp-6282	378	19	2000	2000	NUM
fnp-6282	378	20	)	)	PUNCT
fnp-6282	378	21	the	the	DET
fnp-6282	378	22	importance	importance	NOUN
fnp-6282	378	23	of	of	ADP
fnp-6282	378	24	the	the	DET
fnp-6282	378	25	five	five	NUM
fnp-6282	378	26	phosphoribosyl	phosphoribosyl	ADJ
fnp-6282	378	27	-	-	PUNCT
fnp-6282	378	28	pyrophosphate	pyrophosphate	NOUN
fnp-6282	378	29	synthetase	synthetase	NOUN
fnp-6282	378	30	(	(	PUNCT
fnp-6282	378	31	prs	prs	NOUN
fnp-6282	378	32	)	)	PUNCT
fnp-6282	378	33	gene	gene	NOUN
fnp-6282	378	34	products	product	NOUN
fnp-6282	378	35	of	of	ADP
fnp-6282	378	36	saccharomyces	saccharomyce	NOUN
fnp-6282	378	37	cerevisiae	cerevisiae	NOUN
fnp-6282	378	38	in	in	ADP
fnp-6282	378	39	the	the	DET
fnp-6282	378	40	maintenance	maintenance	NOUN
fnp-6282	378	41	of	of	ADP
fnp-6282	378	42	cell	cell	NOUN
fnp-6282	378	43	integrity	integrity	NOUN
fnp-6282	378	44	and	and	CCONJ
fnp-6282	378	45	the	the	DET
fnp-6282	378	46	subcellular	subcellular	ADJ
fnp-6282	378	47	localization	localization	NOUN
fnp-6282	378	48	of	of	ADP
fnp-6282	378	49	prs1p	prs1p	PROPN
fnp-6282	378	50	.	.	PUNCT
fnp-6282	379	1	microbiology	microbiology	NOUN
fnp-6282	379	2	(	(	PUNCT
fnp-6282	379	3	reading	reading	NOUN
fnp-6282	379	4	)	)	PUNCT
fnp-6282	379	5	146	146	NUM
fnp-6282	379	6	pt	pt	NOUN
fnp-6282	379	7	12	12	NUM
fnp-6282	379	8	:	:	SYM
fnp-6282	379	9	3269	3269	NUM
fnp-6282	379	10	-	-	SYM
fnp-6282	379	11	3278	3278	NUM
fnp-6282	379	12	.	.	PUNCT
fnp-6282	380	1	https://doi.org/10.1099/00221287-146-12-3269	https://doi.org/10.1099/00221287-146-12-3269	PROPN
fnp-6282	380	2	58	58	NUM
fnp-6282	380	3	.	.	PUNCT
fnp-6282	381	1	simonet	simonet	PROPN
fnp-6282	381	2	jc	jc	PROPN
fnp-6282	381	3	,	,	PUNCT
fnp-6282	381	4	burrell	burrell	PROPN
fnp-6282	381	5	al	al	PROPN
fnp-6282	381	6	,	,	PUNCT
fnp-6282	381	7	kollman	kollman	PROPN
fnp-6282	381	8	jm	jm	PROPN
fnp-6282	381	9	,	,	PUNCT
fnp-6282	381	10	peterson	peterson	PROPN
fnp-6282	381	11	jr	jr	PROPN
fnp-6282	381	12	(	(	PUNCT
fnp-6282	381	13	2020	2020	NUM
fnp-6282	381	14	)	)	PUNCT
fnp-6282	381	15	freedom	freedom	NOUN
fnp-6282	381	16	of	of	ADP
fnp-6282	381	17	assembly	assembly	NOUN
fnp-6282	381	18	:	:	PUNCT
fnp-6282	381	19	metabolic	metabolic	NOUN
fnp-6282	381	20	enzymes	enzyme	NOUN
fnp-6282	381	21	come	come	VERB
fnp-6282	381	22	together	together	ADV
fnp-6282	381	23	.	.	PUNCT
fnp-6282	382	1	mol	mol	ADP
fnp-6282	382	2	biol	biol	PROPN
fnp-6282	382	3	cell	cell	NOUN
fnp-6282	382	4	31	31	NUM
fnp-6282	382	5	:	:	PUNCT
fnp-6282	382	6	1201	1201	NUM
fnp-6282	382	7	-	-	SYM
fnp-6282	382	8	1205	1205	NUM
fnp-6282	382	9	.	.	PUNCT
fnp-6282	383	1	https://doi.org/10.1091/mbc.e18-10-0675	https://doi.org/10.1091/mbc.e18-10-0675	PROPN
fnp-6282	383	2	59	59	NUM
fnp-6282	383	3	.	.	PUNCT
fnp-6282	384	1	tasca	tasca	PROPN
fnp-6282	384	2	ci	ci	PROPN
fnp-6282	384	3	,	,	PUNCT
fnp-6282	384	4	lanznaster	lanznaster	PROPN
fnp-6282	384	5	d	d	PROPN
fnp-6282	384	6	,	,	PUNCT
fnp-6282	384	7	oliveira	oliveira	PROPN
fnp-6282	384	8	ka	ka	PROPN
fnp-6282	384	9	,	,	PUNCT
fnp-6282	384	10	fernandez	fernandez	PROPN
fnp-6282	384	11	-	-	PUNCT
fnp-6282	384	12	duenas	duenas	PROPN
fnp-6282	384	13	v	v	NOUN
fnp-6282	384	14	,	,	PUNCT
fnp-6282	384	15	ciruela	ciruela	PROPN
fnp-6282	384	16	f	f	PROPN
fnp-6282	384	17	(	(	PUNCT
fnp-6282	384	18	2018	2018	NUM
fnp-6282	384	19	)	)	PUNCT
fnp-6282	384	20	neuromodulatory	neuromodulatory	ADJ
fnp-6282	384	21	effects	effect	NOUN
fnp-6282	384	22	of	of	ADP
fnp-6282	384	23	guanine	guanine	NOUN
fnp-6282	384	24	-	-	PUNCT
fnp-6282	384	25	based	base	VERB
fnp-6282	384	26	purines	purine	NOUN
fnp-6282	384	27	in	in	ADP
fnp-6282	384	28	health	health	NOUN
fnp-6282	384	29	and	and	CCONJ
fnp-6282	384	30	disease	disease	NOUN
fnp-6282	384	31	.	.	PUNCT
fnp-6282	385	1	front	front	ADJ
fnp-6282	385	2	cell	cell	NOUN
fnp-6282	385	3	neurosci	neurosci	NOUN
fnp-6282	385	4	12	12	NUM
fnp-6282	385	5	:	:	SYM
fnp-6282	385	6	376	376	NUM
fnp-6282	385	7	.	.	PUNCT
fnp-6282	386	1	https://doi.org/10.3389/fncel.2018.00376	https://doi.org/10.3389/fncel.2018.00376	PROPN
fnp-6282	386	2	60	60	NUM
fnp-6282	386	3	.	.	PUNCT
fnp-6282	387	1	thal	thal	PROPN
fnp-6282	387	2	dr	dr	PROPN
fnp-6282	387	3	,	,	PUNCT
fnp-6282	387	4	rub	rub	PROPN
fnp-6282	387	5	u	u	NOUN
fnp-6282	387	6	,	,	PUNCT
fnp-6282	387	7	orantes	orantes	PROPN
fnp-6282	387	8	m	m	PROPN
fnp-6282	387	9	,	,	PUNCT
fnp-6282	387	10	braak	braak	PROPN
fnp-6282	387	11	h	h	PROPN
fnp-6282	387	12	(	(	PUNCT
fnp-6282	387	13	2002	2002	NUM
fnp-6282	387	14	)	)	PUNCT
fnp-6282	387	15	phases	phase	NOUN
fnp-6282	387	16	of	of	ADP
fnp-6282	387	17	a	a	DET
fnp-6282	387	18	beta	beta	NOUN
fnp-6282	387	19	-	-	PUNCT
fnp-6282	387	20	deposition	deposition	NOUN
fnp-6282	387	21	in	in	ADP
fnp-6282	387	22	the	the	DET
fnp-6282	387	23	human	human	ADJ
fnp-6282	387	24	brain	brain	NOUN
fnp-6282	387	25	and	and	CCONJ
fnp-6282	387	26	its	its	PRON
fnp-6282	387	27	relevance	relevance	NOUN
fnp-6282	387	28	for	for	ADP
fnp-6282	387	29	the	the	DET
fnp-6282	387	30	development	development	NOUN
fnp-6282	387	31	of	of	ADP
fnp-6282	387	32	ad	ad	NOUN
fnp-6282	387	33	.	.	PUNCT
fnp-6282	387	34	neurology	neurology	NOUN
fnp-6282	387	35	58	58	NUM
fnp-6282	387	36	:	:	PUNCT
fnp-6282	387	37	1791	1791	NUM
fnp-6282	387	38	-	-	SYM
fnp-6282	387	39	1800	1800	NUM
fnp-6282	387	40	.	.	PUNCT
fnp-6282	388	1	https://doi.org/10.1212/wnl.58.12.1791	https://doi.org/10.1212/wnl.58.12.1791	PROPN
fnp-6282	388	2	61	61	NUM
fnp-6282	388	3	.	.	PUNCT
fnp-6282	389	1	tolias	tolias	PROPN
fnp-6282	389	2	kf	kf	PROPN
fnp-6282	389	3	,	,	PUNCT
fnp-6282	389	4	duman	duman	PROPN
fnp-6282	389	5	jg	jg	PROPN
fnp-6282	389	6	,	,	PUNCT
fnp-6282	389	7	um	um	INTJ
fnp-6282	389	8	k	k	X
fnp-6282	389	9	(	(	PUNCT
fnp-6282	389	10	2011	2011	NUM
fnp-6282	389	11	)	)	PUNCT
fnp-6282	389	12	control	control	NOUN
fnp-6282	389	13	of	of	ADP
fnp-6282	389	14	synapse	synapse	NOUN
fnp-6282	389	15	development	development	NOUN
fnp-6282	389	16	and	and	CCONJ
fnp-6282	389	17	plasticity	plasticity	NOUN
fnp-6282	389	18	by	by	ADP
fnp-6282	389	19	rho	rho	ADJ
fnp-6282	389	20	gtpase	gtpase	NOUN
fnp-6282	389	21	regulatory	regulatory	ADJ
fnp-6282	389	22	proteins	protein	NOUN
fnp-6282	389	23	.	.	PUNCT
fnp-6282	390	1	prog	prog	NOUN
fnp-6282	390	2	neurobiol	neurobiol	PROPN
fnp-6282	390	3	94	94	NUM
fnp-6282	390	4	:	:	PUNCT
fnp-6282	390	5	133	133	NUM
fnp-6282	390	6	-	-	SYM
fnp-6282	390	7	148	148	NUM
fnp-6282	390	8	.	.	PUNCT
fnp-6282	391	1	https://doi.org/10.1016/j.pneurobio.2011.04.011	https://doi.org/10.1016/j.pneurobio.2011.04.011	NUM
fnp-6282	391	2	62	62	NUM
fnp-6282	391	3	.	.	PUNCT
fnp-6282	392	1	wolfe	wolfe	PROPN
fnp-6282	392	2	k	k	PROPN
fnp-6282	392	3	,	,	PUNCT
fnp-6282	392	4	kofuji	kofuji	PROPN
fnp-6282	392	5	s	s	PROPN
fnp-6282	392	6	,	,	PUNCT
fnp-6282	392	7	yoshino	yoshino	ADJ
fnp-6282	392	8	h	h	NOUN
fnp-6282	392	9	,	,	PUNCT
fnp-6282	392	10	sasaki	sasaki	PROPN
fnp-6282	392	11	m	m	PROPN
fnp-6282	392	12	,	,	PUNCT
fnp-6282	392	13	okumura	okumura	PROPN
fnp-6282	392	14	k	k	PROPN
fnp-6282	392	15	,	,	PUNCT
fnp-6282	392	16	sasaki	sasaki	PROPN
fnp-6282	392	17	at	at	ADP
fnp-6282	392	18	(	(	PUNCT
fnp-6282	392	19	2019	2019	NUM
fnp-6282	392	20	)	)	PUNCT
fnp-6282	392	21	dynamic	dynamic	ADJ
fnp-6282	392	22	compartmentalization	compartmentalization	NOUN
fnp-6282	392	23	of	of	ADP
fnp-6282	392	24	purine	purine	NOUN
fnp-6282	392	25	nucleotide	nucleotide	NOUN
fnp-6282	392	26	metabolic	metabolic	NOUN
fnp-6282	392	27	enzymes	enzyme	NOUN
fnp-6282	392	28	at	at	ADP
fnp-6282	392	29	leading	lead	VERB
fnp-6282	392	30	edge	edge	NOUN
fnp-6282	392	31	in	in	ADP
fnp-6282	392	32	highly	highly	ADV
fnp-6282	392	33	motile	motile	ADJ
fnp-6282	392	34	renal	renal	ADJ
fnp-6282	392	35	cell	cell	NOUN
fnp-6282	392	36	carcinoma	carcinoma	NOUN
fnp-6282	392	37	.	.	PUNCT
fnp-6282	393	1	biochem	biochem	PROPN
fnp-6282	393	2	biophys	biophys	PROPN
fnp-6282	393	3	res	re	NOUN
fnp-6282	393	4	commun	commun	PROPN
fnp-6282	393	5	516	516	NUM
fnp-6282	393	6	:	:	PUNCT
fnp-6282	393	7	50	50	NUM
fnp-6282	393	8	-	-	SYM
fnp-6282	393	9	56	56	NUM
fnp-6282	393	10	.	.	PUNCT
fnp-6282	394	1	https://doi.org/10.1016/j.bbrc.2019.05.190	https://doi.org/10.1016/j.bbrc.2019.05.190	PROPN
fnp-6282	394	2	63	63	NUM
fnp-6282	394	3	.	.	PUNCT
fnp-6282	395	1	woulfe	woulfe	PROPN
fnp-6282	395	2	j	j	PROPN
fnp-6282	395	3	,	,	PUNCT
fnp-6282	395	4	munoz	munoz	PROPN
fnp-6282	395	5	d	d	PROPN
fnp-6282	395	6	(	(	PUNCT
fnp-6282	395	7	2024	2024	NUM
fnp-6282	395	8	)	)	PUNCT
fnp-6282	395	9	roncoroni	roncoroni	VERB
fnp-6282	395	10	re	re	VERB
fnp-6282	395	11	-	-	VERB
fnp-6282	395	12	visited	visited	ADJ
fnp-6282	395	13	:	:	PUNCT
fnp-6282	395	14	the	the	DET
fnp-6282	395	15	neuronal	neuronal	ADJ
fnp-6282	395	16	intranuclear	intranuclear	NOUN
fnp-6282	395	17	rodlet	rodlet	NOUN
fnp-6282	395	18	comes	come	VERB
fnp-6282	395	19	of	of	ADP
fnp-6282	395	20	age	age	NOUN
fnp-6282	395	21	.	.	PUNCT
fnp-6282	396	1	j	j	PROPN
fnp-6282	396	2	comp	comp	PROPN
fnp-6282	396	3	neurol	neurol	PROPN
fnp-6282	396	4	532	532	NUM
fnp-6282	396	5	:	:	PUNCT
fnp-6282	396	6	e25662	e25662	NOUN
fnp-6282	396	7	.	.	PUNCT
fnp-6282	397	1	https://doi.org/10.1002/cne.25662	https://doi.org/10.1002/cne.25662	PROPN
fnp-6282	397	2	64	64	NUM
fnp-6282	397	3	.	.	PUNCT
fnp-6282	398	1	woulfe	woulfe	PROPN
fnp-6282	398	2	j	j	PROPN
fnp-6282	398	3	,	,	PUNCT
fnp-6282	398	4	munoz	munoz	PROPN
fnp-6282	398	5	dg	dg	PROPN
fnp-6282	398	6	,	,	PUNCT
fnp-6282	398	7	gray	gray	ADJ
fnp-6282	398	8	da	da	PROPN
fnp-6282	398	9	,	,	PUNCT
fnp-6282	398	10	jinnah	jinnah	PROPN
fnp-6282	398	11	ha	ha	PROPN
fnp-6282	398	12	,	,	PUNCT
fnp-6282	398	13	ivanova	ivanova	PROPN
fnp-6282	398	14	a	a	DET
fnp-6282	398	15	(	(	PUNCT
fnp-6282	398	16	2024	2024	NUM
fnp-6282	398	17	)	)	PUNCT
fnp-6282	398	18	inosine	inosine	NOUN
fnp-6282	398	19	monophosphate	monophosphate	NOUN
fnp-6282	398	20	dehydrogenase	dehydrogenase	NOUN
fnp-6282	398	21	intranuclear	intranuclear	NOUN
fnp-6282	398	22	inclusions	inclusion	NOUN
fnp-6282	398	23	are	be	AUX
fnp-6282	398	24	markers	marker	NOUN
fnp-6282	398	25	of	of	ADP
fnp-6282	398	26	aging	age	VERB
fnp-6282	398	27	and	and	CCONJ
fnp-6282	398	28	neuronal	neuronal	ADJ
fnp-6282	398	29	stress	stress	NOUN
fnp-6282	398	30	in	in	ADP
fnp-6282	398	31	the	the	DET
fnp-6282	398	32	human	human	ADJ
fnp-6282	398	33	substantia	substantia	NOUN
fnp-6282	398	34	nigra	nigra	PROPN
fnp-6282	398	35	.	.	PUNCT
fnp-6282	399	1	neurobiol	neurobiol	PROPN
fnp-6282	399	2	aging	age	VERB
fnp-6282	399	3	134	134	NUM
fnp-6282	399	4	:	:	SYM
fnp-6282	399	5	43	43	NUM
fnp-6282	399	6	-	-	SYM
fnp-6282	399	7	56	56	NUM
fnp-6282	399	8	.	.	PUNCT
fnp-6282	400	1	https://doi.org/10.1016/j.neurobiolaging.2023.11.005	https://doi.org/10.1016/j.neurobiolaging.2023.11.005	NOUN
fnp-6282	400	2	65	65	NUM
fnp-6282	400	3	.	.	PUNCT
fnp-6282	400	4	woulfe	woulfe	PROPN
fnp-6282	400	5	jm	jm	PROPN
fnp-6282	400	6	,	,	PUNCT
fnp-6282	400	7	hammond	hammond	PROPN
fnp-6282	400	8	r	r	PROPN
fnp-6282	400	9	,	,	PUNCT
fnp-6282	400	10	richardson	richardson	PROPN
fnp-6282	400	11	b	b	PROPN
fnp-6282	400	12	,	,	PUNCT
fnp-6282	400	13	sooriabalan	sooriabalan	NOUN
fnp-6282	400	14	d	d	PROPN
fnp-6282	400	15	,	,	PUNCT
fnp-6282	400	16	parks	parks	PROPN
fnp-6282	400	17	w	w	PROPN
fnp-6282	400	18	,	,	PUNCT
fnp-6282	400	19	rippstein	rippstein	VERB
fnp-6282	400	20	p	p	X
fnp-6282	400	21	,	,	PUNCT
fnp-6282	400	22	munoz	munoz	PROPN
fnp-6282	400	23	dg	dg	PROPN
fnp-6282	400	24	(	(	PUNCT
fnp-6282	400	25	2002	2002	NUM
fnp-6282	400	26	)	)	PUNCT
fnp-6282	400	27	reduction	reduction	NOUN
fnp-6282	400	28	of	of	ADP
fnp-6282	400	29	neuronal	neuronal	ADJ
fnp-6282	400	30	intranuclear	intranuclear	NOUN
fnp-6282	400	31	rodlets	rodlet	NOUN
fnp-6282	400	32	immunoreactive	immunoreactive	ADJ
fnp-6282	400	33	for	for	ADP
fnp-6282	400	34	tubulin	tubulin	NOUN
fnp-6282	400	35	and	and	CCONJ
fnp-6282	400	36	glucocorticoid	glucocorticoid	ADJ
fnp-6282	400	37	receptor	receptor	NOUN
fnp-6282	400	38	in	in	ADP
fnp-6282	400	39	alzheimer	alzheimer	PROPN
fnp-6282	400	40	's	's	PART
fnp-6282	400	41	disease	disease	NOUN
fnp-6282	400	42	.	.	PUNCT
fnp-6282	401	1	brain	brain	NOUN
fnp-6282	401	2	pathol	pathol	NOUN
fnp-6282	401	3	12	12	NUM
fnp-6282	401	4	:	:	PUNCT
fnp-6282	401	5	300	300	NUM
fnp-6282	401	6	-	-	SYM
fnp-6282	401	7	307	307	NUM
fnp-6282	401	8	.	.	PUNCT
fnp-6282	402	1	https://doi.org/10.1111/j.1750-3639.2002.tb00444.x	https://doi.org/10.1111/j.1750-3639.2002.tb00444.x	PROPN
fnp-6282	402	2	66	66	NUM
fnp-6282	402	3	.	.	PUNCT
fnp-6282	403	1	zech	zech	PROPN
fnp-6282	403	2	m	m	PROPN
fnp-6282	403	3	,	,	PUNCT
fnp-6282	403	4	jech	jech	PROPN
fnp-6282	403	5	r	r	PROPN
fnp-6282	403	6	,	,	PUNCT
fnp-6282	403	7	boesch	boesch	PROPN
fnp-6282	403	8	s	s	PART
fnp-6282	403	9	,	,	PUNCT
fnp-6282	403	10	skorvanek	skorvanek	ADJ
fnp-6282	403	11	m	m	PROPN
fnp-6282	403	12	,	,	PUNCT
fnp-6282	403	13	weber	weber	PROPN
fnp-6282	403	14	s	s	PROPN
fnp-6282	403	15	,	,	PUNCT
fnp-6282	403	16	wagner	wagner	PROPN
fnp-6282	403	17	m	m	PROPN
fnp-6282	403	18	,	,	PUNCT
fnp-6282	403	19	zhao	zhao	PROPN
fnp-6282	403	20	c	c	PROPN
fnp-6282	403	21	,	,	PUNCT
fnp-6282	403	22	jochim	jochim	NOUN
fnp-6282	403	23	a	a	PRON
fnp-6282	403	24	,	,	PUNCT
fnp-6282	403	25	necpal	necpal	ADJ
fnp-6282	403	26	j	j	PROPN
fnp-6282	403	27	,	,	PUNCT
fnp-6282	403	28	dincer	dincer	PROPN
fnp-6282	403	29	yet	yet	ADV
fnp-6282	403	30	al	al	PROPN
fnp-6282	403	31	(	(	PUNCT
fnp-6282	403	32	2020	2020	NUM
fnp-6282	403	33	)	)	PUNCT
fnp-6282	403	34	monogenic	monogenic	ADJ
fnp-6282	403	35	variants	variant	NOUN
fnp-6282	403	36	in	in	ADP
fnp-6282	403	37	dystonia	dystonia	NOUN
fnp-6282	403	38	:	:	PUNCT
fnp-6282	403	39	an	an	DET
fnp-6282	403	40	exome	exome	NOUN
fnp-6282	403	41	-	-	PUNCT
fnp-6282	403	42	wide	wide	ADJ
fnp-6282	403	43	sequencing	sequencing	NOUN
fnp-6282	403	44	study	study	NOUN
fnp-6282	403	45	.	.	PUNCT
fnp-6282	404	1	lancet	lancet	PROPN
fnp-6282	404	2	neurol	neurol	PROPN
fnp-6282	404	3	19	19	NUM
fnp-6282	404	4	:	:	PUNCT
fnp-6282	404	5	908	908	NUM
fnp-6282	404	6	-	-	SYM
fnp-6282	404	7	918	918	NUM
fnp-6282	404	8	.	.	PUNCT
fnp-6282	404	9	https://doi.org/10.1016/s1474-4422(20)30312-4	https://doi.org/10.1016/s1474-4422(20)30312-4	VERB
fnp-6282	404	10	67	67	NUM
fnp-6282	404	11	.	.	PUNCT
fnp-6282	405	1	zhao	zhao	PROPN
fnp-6282	405	2	h	h	PROPN
fnp-6282	405	3	,	,	PUNCT
fnp-6282	405	4	chiaro	chiaro	PROPN
fnp-6282	405	5	cr	cr	PROPN
fnp-6282	405	6	,	,	PUNCT
fnp-6282	405	7	zhang	zhang	PROPN
fnp-6282	405	8	l	l	PROPN
fnp-6282	405	9	,	,	PUNCT
fnp-6282	405	10	smith	smith	PROPN
fnp-6282	405	11	pb	pb	PROPN
fnp-6282	405	12	,	,	PUNCT
fnp-6282	405	13	chan	chan	PROPN
fnp-6282	405	14	cy	cy	PROPN
fnp-6282	405	15	,	,	PUNCT
fnp-6282	405	16	pedley	pedley	PROPN
fnp-6282	405	17	am	am	PROPN
fnp-6282	405	18	,	,	PUNCT
fnp-6282	405	19	pugh	pugh	PROPN
fnp-6282	405	20	rj	rj	PROPN
fnp-6282	405	21	,	,	PUNCT
fnp-6282	405	22	french	french	PROPN
fnp-6282	405	23	jb	jb	PROPN
fnp-6282	405	24	,	,	PUNCT
fnp-6282	405	25	patterson	patterson	PROPN
fnp-6282	405	26	ad	ad	NOUN
fnp-6282	405	27	,	,	PUNCT
fnp-6282	405	28	benkovic	benkovic	VERB
fnp-6282	405	29	sj	sj	PROPN
fnp-6282	405	30	(	(	PUNCT
fnp-6282	405	31	2015	2015	NUM
fnp-6282	405	32	)	)	PUNCT
fnp-6282	405	33	quantitative	quantitative	ADJ
fnp-6282	405	34	analysis	analysis	NOUN
fnp-6282	405	35	of	of	ADP
fnp-6282	405	36	purine	purine	NOUN
fnp-6282	405	37	nucleotides	nucleotide	NOUN
fnp-6282	405	38	indicates	indicate	VERB
fnp-6282	405	39	that	that	SCONJ
fnp-6282	405	40	purinosomes	purinosome	NOUN
fnp-6282	405	41	increase	increase	VERB
fnp-6282	405	42	de	de	X
fnp-6282	405	43	novo	novo	NOUN
fnp-6282	405	44	purine	purine	NOUN
fnp-6282	405	45	biosynthesis	biosynthesis	NOUN
fnp-6282	405	46	.	.	PUNCT
fnp-6282	406	1	j	j	PROPN
fnp-6282	406	2	biol	biol	PROPN
fnp-6282	406	3	chem	chem	NOUN
fnp-6282	406	4	290	290	NUM
fnp-6282	406	5	:	:	SYM
fnp-6282	406	6	6705	6705	NUM
fnp-6282	406	7	-	-	SYM
fnp-6282	406	8	6713	6713	NUM
fnp-6282	406	9	.	.	PUNCT
fnp-6282	407	1	https://doi.org/10.1074/jbc.m114.628701	https://doi.org/10.1074/jbc.m114.628701	ADP
fnp-6282	407	2	68	68	NUM
fnp-6282	407	3	.	.	PUNCT
fnp-6282	408	1	zhou	zhou	PROPN
fnp-6282	408	2	yy	yy	PROPN
fnp-6282	408	3	,	,	PUNCT
fnp-6282	408	4	el	el	PROPN
fnp-6282	408	5	hallani	hallani	PROPN
fnp-6282	408	6	s	s	PROPN
fnp-6282	408	7	,	,	PUNCT
fnp-6282	408	8	balaa	balaa	PROPN
fnp-6282	409	1	f	f	X
fnp-6282	409	2	,	,	PUNCT
fnp-6282	409	3	mohammad	mohammad	PROPN
fnp-6282	409	4	w	w	PROPN
fnp-6282	409	5	,	,	PUNCT
fnp-6282	409	6	gray	gray	ADJ
fnp-6282	409	7	da	da	NOUN
fnp-6282	409	8	,	,	PUNCT
fnp-6282	409	9	woulfe	woulfe	VERB
fnp-6282	409	10	j	j	PROPN
fnp-6282	409	11	(	(	PUNCT
fnp-6282	409	12	2017	2017	NUM
fnp-6282	409	13	)	)	PUNCT
fnp-6282	409	14	depletion	depletion	NOUN
fnp-6282	409	15	of	of	ADP
fnp-6282	409	16	beta	beta	ADJ
fnp-6282	409	17	cell	cell	NOUN
fnp-6282	409	18	intranuclear	intranuclear	NOUN
fnp-6282	409	19	rodlets	rodlet	NOUN
fnp-6282	409	20	in	in	ADP
fnp-6282	409	21	human	human	ADJ
fnp-6282	409	22	type	type	NOUN
fnp-6282	409	23	ii	ii	NOUN
fnp-6282	409	24	diabetes	diabetes	NOUN
fnp-6282	409	25	.	.	PUNCT
fnp-6282	410	1	endocr	endocr	PROPN
fnp-6282	410	2	pathol	pathol	NOUN
fnp-6282	410	3	28	28	NUM
fnp-6282	410	4	:	:	SYM
fnp-6282	410	5	282	282	NUM
fnp-6282	410	6	-	-	SYM
fnp-6282	410	7	286	286	NUM
fnp-6282	410	8	.	.	PUNCT
fnp-6282	411	1	https://doi.org/10.1007/s12022-017-9499-y	https://doi.org/10.1007/s12022-017-9499-y	NOUN
fnp-6282	411	2	copyright	copyright	NOUN
fnp-6282	411	3	:	:	PUNCT
fnp-6282	411	4	©	©	PROPN
fnp-6282	411	5	2025	2025	NUM
fnp-6282	411	6	the	the	DET
fnp-6282	411	7	author(s	author(s	NOUN
fnp-6282	411	8	)	)	PUNCT
fnp-6282	411	9	.	.	PUNCT
fnp-6282	412	1	this	this	PRON
fnp-6282	412	2	is	be	AUX
fnp-6282	412	3	an	an	DET
fnp-6282	412	4	open	open	ADJ
fnp-6282	412	5	access	access	NOUN
fnp-6282	412	6	article	article	NOUN
fnp-6282	412	7	distributed	distribute	VERB
fnp-6282	412	8	under	under	ADP
fnp-6282	412	9	the	the	DET
fnp-6282	412	10	terms	term	NOUN
fnp-6282	412	11	of	of	ADP
fnp-6282	412	12	the	the	DET
fnp-6282	412	13	creative	creative	ADJ
fnp-6282	412	14	commons	common	NOUN
fnp-6282	412	15	attribution	attribution	NOUN
fnp-6282	412	16	4.0	4.0	NUM
fnp-6282	412	17	international	international	ADJ
fnp-6282	412	18	license	license	NOUN
fnp-6282	412	19	(	(	PUNCT
fnp-6282	412	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-6282	412	21	)	)	PUNCT
fnp-6282	412	22	,	,	PUNCT
fnp-6282	412	23	which	which	PRON
fnp-6282	412	24	permits	permit	VERB
fnp-6282	412	25	unrestricted	unrestricted	ADJ
fnp-6282	412	26	use	use	NOUN
fnp-6282	412	27	,	,	PUNCT
fnp-6282	412	28	distribution	distribution	NOUN
fnp-6282	412	29	,	,	PUNCT
fnp-6282	412	30	and	and	CCONJ
fnp-6282	412	31	reproduction	reproduction	NOUN
fnp-6282	412	32	in	in	ADP
fnp-6282	412	33	any	any	DET
fnp-6282	412	34	medium	medium	NOUN
fnp-6282	412	35	,	,	PUNCT
fnp-6282	412	36	provided	provide	VERB
fnp-6282	412	37	the	the	DET
fnp-6282	412	38	original	original	ADJ
fnp-6282	412	39	author	author	NOUN
fnp-6282	412	40	and	and	CCONJ
fnp-6282	412	41	source	source	NOUN
fnp-6282	412	42	are	be	AUX
fnp-6282	412	43	credited	credit	VERB
fnp-6282	412	44	,	,	PUNCT
fnp-6282	412	45	a	a	DET
fnp-6282	412	46	link	link	NOUN
fnp-6282	412	47	to	to	ADP
fnp-6282	412	48	the	the	DET
fnp-6282	412	49	creative	creative	ADJ
fnp-6282	412	50	commons	common	NOUN
fnp-6282	412	51	license	license	NOUN
fnp-6282	412	52	is	be	AUX
fnp-6282	412	53	provided	provide	VERB
fnp-6282	412	54	,	,	PUNCT
fnp-6282	412	55	and	and	CCONJ
fnp-6282	412	56	any	any	DET
fnp-6282	412	57	changes	change	NOUN
fnp-6282	412	58	are	be	AUX
fnp-6282	412	59	indicated	indicate	VERB
fnp-6282	412	60	.	.	PUNCT
fnp-6282	413	1	the	the	DET
fnp-6282	413	2	creative	creative	ADJ
fnp-6282	413	3	commons	common	NOUN
fnp-6282	413	4	public	public	ADJ
fnp-6282	413	5	domain	domain	NOUN
fnp-6282	413	6	dedication	dedication	NOUN
fnp-6282	413	7	waiver	waiver	NOUN
fnp-6282	413	8	(	(	PUNCT
fnp-6282	413	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-6282	413	10	)	)	PUNCT
fnp-6282	413	11	applies	apply	VERB
fnp-6282	413	12	to	to	ADP
fnp-6282	413	13	the	the	DET
fnp-6282	413	14	data	datum	NOUN
fnp-6282	413	15	made	make	VERB
fnp-6282	413	16	available	available	ADJ
fnp-6282	413	17	in	in	ADP
fnp-6282	413	18	this	this	DET
fnp-6282	413	19	article	article	NOUN
fnp-6282	413	20	,	,	PUNCT
fnp-6282	413	21	unless	unless	SCONJ
fnp-6282	413	22	otherwise	otherwise	ADV
fnp-6282	413	23	stated	state	VERB
fnp-6282	413	24	.	.	PUNCT