id sid tid token lemma pos fnp-6284 1 1 64th 64th ADJ fnp-6284 1 2 annual annual ADJ fnp-6284 1 3 meeting meeting NOUN fnp-6284 1 4 of of ADP fnp-6284 1 5 the the DET fnp-6284 1 6 canadian canadian PROPN fnp-6284 1 7 association association PROPN fnp-6284 1 8 of of ADP fnp-6284 1 9 neuropathologists neuropathologists PROPN fnp-6284 1 10 association association PROPN fnp-6284 1 11 canadienne canadienne PROPN fnp-6284 1 12 des des PROPN fnp-6284 1 13 neuropathologistes neuropathologistes PROPN fnp-6284 1 14 ( ( PUNCT fnp-6284 1 15 canp canp NOUN fnp-6284 1 16 - - PUNCT fnp-6284 1 17 acnp acnp NOUN fnp-6284 1 18 ) ) PUNCT fnp-6284 1 19 feel feel VERB fnp-6284 1 20 free free ADJ fnp-6284 1 21 to to PART fnp-6284 1 22 add add VERB fnp-6284 1 23 comments comment NOUN fnp-6284 1 24 by by ADP fnp-6284 1 25 clicking click VERB fnp-6284 1 26 these these DET fnp-6284 1 27 icons icon NOUN fnp-6284 1 28 on on ADP fnp-6284 1 29 the the DET fnp-6284 1 30 sidebar sidebar NOUN fnp-6284 1 31 free free ADJ fnp-6284 1 32 neuropathology neuropathology NOUN fnp-6284 1 33 6:1(2025 6:1(2025 NUM fnp-6284 1 34 ) ) PUNCT fnp-6284 1 35 meeting meeting NOUN fnp-6284 1 36 abstracts abstract VERB fnp-6284 1 37 64th 64th ADJ fnp-6284 1 38 annual annual ADJ fnp-6284 1 39 meeting meeting NOUN fnp-6284 1 40 of of ADP fnp-6284 1 41 the the DET fnp-6284 1 42 canadian canadian PROPN fnp-6284 1 43 association association PROPN fnp-6284 1 44 of of ADP fnp-6284 1 45 neuropathologists neuropathologists PROPN fnp-6284 1 46 association association PROPN fnp-6284 1 47 canadienne canadienne PROPN fnp-6284 1 48 des des PROPN fnp-6284 1 49 neuropathologistes neuropathologistes PROPN fnp-6284 1 50 ( ( PUNCT fnp-6284 1 51 canp canp NOUN fnp-6284 1 52 - - PUNCT fnp-6284 1 53 acnp acnp NOUN fnp-6284 1 54 ) ) PUNCT fnp-6284 1 55 meeting meeting NOUN fnp-6284 1 56 abstracts abstract VERB fnp-6284 1 57 october october PROPN fnp-6284 1 58 3rd–5th 3rd–5th NUM fnp-6284 1 59 , , PUNCT fnp-6284 1 60 2024 2024 NUM fnp-6284 1 61 toronto toronto PROPN fnp-6284 1 62 , , PUNCT fnp-6284 1 63 on on ADP fnp-6284 1 64 submitted submit VERB fnp-6284 1 65 : : PUNCT fnp-6284 1 66 04 04 NUM fnp-6284 1 67 december december PROPN fnp-6284 1 68 2024 2024 NUM fnp-6284 1 69 accepted accept VERB fnp-6284 1 70 : : PUNCT fnp-6284 1 71 05 05 NUM fnp-6284 1 72 december december PROPN fnp-6284 1 73 2024 2024 NUM fnp-6284 1 74 published publish VERB fnp-6284 1 75 : : PUNCT fnp-6284 1 76 29 29 NUM fnp-6284 1 77 january january NOUN fnp-6284 1 78 2025 2025 NUM fnp-6284 1 79     SPACE fnp-6284 1 80 the the DET fnp-6284 1 81 canadian canadian PROPN fnp-6284 1 82 association association NOUN fnp-6284 1 83 of of ADP fnp-6284 1 84 neuropathologist neuropathologist ADJ fnp-6284 1 85 – – PUNCT fnp-6284 1 86 association association PROPN fnp-6284 1 87 canadienne canadienne PROPN fnp-6284 1 88 des des X fnp-6284 1 89 neuropathologistes neuropathologistes PROPN fnp-6284 1 90 ( ( PUNCT fnp-6284 1 91 canp canp NOUN fnp-6284 1 92 - - PUNCT fnp-6284 1 93 acnp acnp NOUN fnp-6284 1 94 ) ) PUNCT fnp-6284 1 95 held hold VERB fnp-6284 1 96 their their PRON fnp-6284 1 97 64th 64th ADJ fnp-6284 1 98 annual annual ADJ fnp-6284 1 99 meeting meeting NOUN fnp-6284 1 100 at at ADP fnp-6284 1 101 the the DET fnp-6284 1 102 sickkids sickkid NOUN fnp-6284 1 103 – – PUNCT fnp-6284 1 104 peter peter PROPN fnp-6284 1 105 gilgan gilgan PROPN fnp-6284 1 106 centre centre NOUN fnp-6284 1 107 for for ADP fnp-6284 1 108 research research NOUN fnp-6284 1 109 and and CCONJ fnp-6284 1 110 learning learning NOUN fnp-6284 1 111 , , PUNCT fnp-6284 1 112 in in ADP fnp-6284 1 113 toronto toronto PROPN fnp-6284 1 114 , , PUNCT fnp-6284 1 115 ontario ontario PROPN fnp-6284 1 116 , , PUNCT fnp-6284 1 117 from from ADP fnp-6284 1 118 october october PROPN fnp-6284 1 119 3rd-5th 3rd-5th NUM fnp-6284 1 120 , , PUNCT fnp-6284 1 121 2024 2024 NUM fnp-6284 1 122 , , PUNCT fnp-6284 1 123 under under ADP fnp-6284 1 124 the the DET fnp-6284 1 125 leadership leadership NOUN fnp-6284 1 126 of of ADP fnp-6284 1 127 dr dr PROPN fnp-6284 1 128 . . PROPN fnp-6284 1 129 robert robert PROPN fnp-6284 1 130 hammond hammond PROPN fnp-6284 1 131 , , PUNCT fnp-6284 1 132 president president NOUN fnp-6284 1 133 of of ADP fnp-6284 1 134 the the DET fnp-6284 1 135 canp canp NOUN fnp-6284 1 136 - - PUNCT fnp-6284 1 137 acnp acnp ADJ fnp-6284 1 138 , , PUNCT fnp-6284 1 139 dr dr PROPN fnp-6284 1 140 . . PROPN fnp-6284 1 141 peter peter PROPN fnp-6284 1 142 schutz schutz PROPN fnp-6284 1 143 , , PUNCT fnp-6284 1 144 secretary secretary NOUN fnp-6284 1 145 treasurer treasurer NOUN fnp-6284 1 146 of of ADP fnp-6284 1 147 the the DET fnp-6284 1 148 canp canp NOUN fnp-6284 1 149 - - PUNCT fnp-6284 1 150 acnp acnp NOUN fnp-6284 1 151 , , PUNCT fnp-6284 1 152 and and CCONJ fnp-6284 1 153 with with ADP fnp-6284 1 154 technical technical ADJ fnp-6284 1 155 support support NOUN fnp-6284 1 156 from from ADP fnp-6284 1 157 canp canp ADJ fnp-6284 1 158 administrator administrator NOUN fnp-6284 1 159 colleen colleen PROPN fnp-6284 1 160 fifield fifield PROPN fnp-6284 1 161 . . PUNCT fnp-6284 2 1 the the DET fnp-6284 2 2 academic academic ADJ fnp-6284 2 3 program program NOUN fnp-6284 2 4 comprised comprise VERB fnp-6284 2 5 13 13 NUM fnp-6284 2 6 scientific scientific ADJ fnp-6284 2 7 abstracts abstract NOUN fnp-6284 2 8 , , PUNCT fnp-6284 2 9 9 9 NUM fnp-6284 2 10 unknown unknown ADJ fnp-6284 2 11 cases case NOUN fnp-6284 2 12 , , PUNCT fnp-6284 2 13 the the DET fnp-6284 2 14 neuropathology neuropathology NOUN fnp-6284 2 15 in in ADP fnp-6284 2 16 practice practice NOUN fnp-6284 2 17 forum forum NOUN fnp-6284 2 18 on on ADP fnp-6284 2 19 molecular molecular ADJ fnp-6284 2 20 testing testing NOUN fnp-6284 2 21 of of ADP fnp-6284 2 22 brain brain NOUN fnp-6284 2 23 tumours tumour NOUN fnp-6284 2 24 in in ADP fnp-6284 2 25 canada canada PROPN fnp-6284 2 26 , , PUNCT fnp-6284 2 27 and and CCONJ fnp-6284 2 28 the the DET fnp-6284 2 29 presidential presidential ADJ fnp-6284 2 30 symposium symposium NOUN fnp-6284 2 31 on on ADP fnp-6284 2 32 looking look VERB fnp-6284 2 33 to to ADP fnp-6284 2 34 the the DET fnp-6284 2 35 future future NOUN fnp-6284 2 36 – – PUNCT fnp-6284 2 37 digital digital ADJ fnp-6284 2 38 pathology pathology NOUN fnp-6284 2 39 and and CCONJ fnp-6284 2 40 spatial spatial ADJ fnp-6284 2 41 transcriptomics transcriptomic NOUN fnp-6284 2 42 . . PUNCT fnp-6284 3 1 digital digital ADJ fnp-6284 3 2 pathology pathology NOUN fnp-6284 3 3 images image VERB fnp-6284 3 4 from from ADP fnp-6284 3 5 the the DET fnp-6284 3 6 9 9 NUM fnp-6284 3 7 unknown unknown ADJ fnp-6284 3 8 cases case NOUN fnp-6284 3 9 were be AUX fnp-6284 3 10 available available ADJ fnp-6284 3 11 for for ADP fnp-6284 3 12 viewing view VERB fnp-6284 3 13 online online ADV fnp-6284 3 14 ( ( PUNCT fnp-6284 3 15 www.canp.ca www.canp.ca NOUN fnp-6284 3 16 ) ) PUNCT fnp-6284 3 17 . . PUNCT fnp-6284 4 1 the the DET fnp-6284 4 2 unknown unknown ADJ fnp-6284 4 3 case case NOUN fnp-6284 4 4 session session NOUN fnp-6284 4 5 was be AUX fnp-6284 4 6 moderated moderate VERB fnp-6284 4 7 by by ADP fnp-6284 4 8 dr dr PROPN fnp-6284 4 9 . . PROPN fnp-6284 4 10 andrew andrew PROPN fnp-6284 4 11 gao gao PROPN fnp-6284 4 12 . . PUNCT fnp-6284 5 1 the the DET fnp-6284 5 2 presidential presidential ADJ fnp-6284 5 3 symposium symposium NOUN fnp-6284 5 4 2024 2024 NUM fnp-6284 5 5 on on ADP fnp-6284 5 6 looking look VERB fnp-6284 5 7 to to ADP fnp-6284 5 8 the the DET fnp-6284 5 9 future future NOUN fnp-6284 5 10 – – PUNCT fnp-6284 5 11 digital digital ADJ fnp-6284 5 12 pathology pathology NOUN fnp-6284 5 13 and and CCONJ fnp-6284 5 14 spatial spatial ADJ fnp-6284 5 15 transcriptomics transcriptomic NOUN fnp-6284 5 16 featured feature VERB fnp-6284 5 17 the the DET fnp-6284 5 18 david david PROPN fnp-6284 5 19 robertson robertson PROPN fnp-6284 5 20 lecture lecture NOUN fnp-6284 5 21 given give VERB fnp-6284 5 22 by by ADP fnp-6284 5 23 dr dr PROPN fnp-6284 5 24 . . PROPN fnp-6284 5 25 a. a. PROPN fnp-6284 5 26 kriegstein kriegstein PROPN fnp-6284 5 27 on on ADP fnp-6284 5 28 transcriptomic transcriptomic ADJ fnp-6284 5 29 cytoarchitecture cytoarchitecture NOUN fnp-6284 5 30 of of ADP fnp-6284 5 31 the the DET fnp-6284 5 32 brain brain NOUN fnp-6284 5 33 , , PUNCT fnp-6284 5 34 and and CCONJ fnp-6284 5 35 the the DET fnp-6284 5 36 jerzy jerzy X fnp-6284 5 37 olszewski olszewski ADJ fnp-6284 5 38 guest guest NOUN fnp-6284 5 39 lecture lecture NOUN fnp-6284 5 40 given give VERB fnp-6284 5 41 by by ADP fnp-6284 5 42 dr dr PROPN fnp-6284 5 43 . . PROPN fnp-6284 5 44 m. m. PROPN fnp-6284 5 45 faiz faiz PROPN fnp-6284 5 46 entitled entitle VERB fnp-6284 5 47 an an DET fnp-6284 5 48 integrated integrate VERB fnp-6284 5 49 single single ADJ fnp-6284 5 50 - - PUNCT fnp-6284 5 51 cell cell NOUN fnp-6284 5 52 and and CCONJ fnp-6284 5 53 spatial spatial ADJ fnp-6284 5 54 transcriptomics transcriptomic NOUN fnp-6284 5 55 approach approach NOUN fnp-6284 5 56 reveals reveal VERB fnp-6284 5 57 the the DET fnp-6284 5 58 heterogeneity heterogeneity NOUN fnp-6284 5 59 of of ADP fnp-6284 5 60 the the DET fnp-6284 5 61 astrocyte astrocyte NOUN fnp-6284 5 62 response response NOUN fnp-6284 5 63 to to AUX fnp-6284 5 64 stroke stroke VERB fnp-6284 5 65 . . PUNCT fnp-6284 6 1 the the DET fnp-6284 6 2 program program NOUN fnp-6284 6 3 was be AUX fnp-6284 6 4 completed complete VERB fnp-6284 6 5 by by ADP fnp-6284 6 6 three three NUM fnp-6284 6 7 invited invite VERB fnp-6284 6 8 presentations presentation NOUN fnp-6284 6 9 with with ADP fnp-6284 6 10 dr dr PROPN fnp-6284 6 11 . . PROPN fnp-6284 6 12 brittany brittany PROPN fnp-6284 6 13 dugger dugger PROPN fnp-6284 6 14 presenting present VERB fnp-6284 6 15 on on ADP fnp-6284 6 16 digital digital ADJ fnp-6284 6 17 pathology pathology NOUN fnp-6284 6 18 applications application NOUN fnp-6284 6 19 in in ADP fnp-6284 6 20 neurodegeneration neurodegeneration NOUN fnp-6284 6 21 , , PUNCT fnp-6284 6 22 dr dr PROPN fnp-6284 6 23 . . PROPN fnp-6284 6 24 s. s. PROPN fnp-6284 6 25 camelo camelo PROPN fnp-6284 6 26 - - PUNCT fnp-6284 6 27 piragua piragua NOUN fnp-6284 6 28 presenting presenting NOUN fnp-6284 6 29 on on ADP fnp-6284 6 30 digital digital ADJ fnp-6284 6 31 pathology pathology NOUN fnp-6284 6 32 applications application NOUN fnp-6284 6 33 in in ADP fnp-6284 6 34 neuro neuro NOUN fnp-6284 6 35 - - PUNCT fnp-6284 6 36 oncology oncology NOUN fnp-6284 6 37 , , PUNCT fnp-6284 6 38 and and CCONJ fnp-6284 6 39 dr dr PROPN fnp-6284 6 40 . . PROPN fnp-6284 6 41 matthew matthew PROPN fnp-6284 6 42 cecchini cecchini PROPN fnp-6284 6 43 presenting present VERB fnp-6284 6 44 on on ADP fnp-6284 6 45 optimizing optimize VERB fnp-6284 6 46 digital digital ADJ fnp-6284 6 47 pathology pathology NOUN fnp-6284 6 48 with with ADP fnp-6284 6 49 ai ai VERB fnp-6284 6 50 : : PUNCT fnp-6284 6 51 strategic strategic ADJ fnp-6284 6 52 approaches approach NOUN fnp-6284 6 53 for for ADP fnp-6284 6 54 modern modern ADJ fnp-6284 6 55 clinical clinical ADJ fnp-6284 6 56 practice practice NOUN fnp-6284 6 57 . . PUNCT fnp-6284 7 1 the the DET fnp-6284 7 2 mary mary PROPN fnp-6284 7 3 tom tom PROPN fnp-6284 7 4 award award PROPN fnp-6284 7 5 for for ADP fnp-6284 7 6 best good ADJ fnp-6284 7 7 clinical clinical ADJ fnp-6284 7 8 science science NOUN fnp-6284 7 9 presentation presentation NOUN fnp-6284 7 10 by by ADP fnp-6284 7 11 a a DET fnp-6284 7 12 trainee trainee NOUN fnp-6284 7 13 went go VERB fnp-6284 7 14 to to ADP fnp-6284 7 15 dr dr PROPN fnp-6284 7 16 . . PROPN fnp-6284 7 17 christopher christopher PROPN fnp-6284 7 18 newell newell PROPN fnp-6284 7 19 ( ( PUNCT fnp-6284 7 20 supervisor supervisor PROPN fnp-6284 7 21 dr dr PROPN fnp-6284 7 22 . . PROPN fnp-6284 7 23 christopher christopher PROPN fnp-6284 7 24 dunham dunham PROPN fnp-6284 7 25 ) ) PUNCT fnp-6284 7 26 , , PUNCT fnp-6284 7 27 and and CCONJ fnp-6284 7 28 the the DET fnp-6284 7 29 morrison morrison PROPN fnp-6284 7 30 h. h. PROPN fnp-6284 7 31 finlayson finlayson PROPN fnp-6284 7 32 award award PROPN fnp-6284 7 33 for for ADP fnp-6284 7 34 best good ADJ fnp-6284 7 35 basic basic ADJ fnp-6284 7 36 science science NOUN fnp-6284 7 37 presentation presentation NOUN fnp-6284 7 38 by by ADP fnp-6284 7 39 a a DET fnp-6284 7 40 trainee trainee NOUN fnp-6284 7 41 was be AUX fnp-6284 7 42 won win VERB fnp-6284 7 43 by by ADP fnp-6284 7 44 dr dr PROPN fnp-6284 7 45 . . PROPN fnp-6284 7 46 erin erin PROPN fnp-6284 7 47 stephenson stephenson PROPN fnp-6284 7 48 ( ( PUNCT fnp-6284 7 49 supervisor supervisor NOUN fnp-6284 7 50 dr dr PROPN fnp-6284 7 51 . . PROPN fnp-6284 7 52 voon voon PROPN fnp-6284 7 53 wee wee PROPN fnp-6284 7 54 yong yong PROPN fnp-6284 7 55 ) ) PUNCT fnp-6284 7 56 . . PUNCT fnp-6284 8 1 the the DET fnp-6284 8 2 following follow VERB fnp-6284 8 3 abstracts abstract NOUN fnp-6284 8 4 were be AUX fnp-6284 8 5 presented present VERB fnp-6284 8 6 at at ADP fnp-6284 8 7 the the DET fnp-6284 8 8 64th 64th ADJ fnp-6284 8 9 annual annual ADJ fnp-6284 8 10 meeting meeting NOUN fnp-6284 8 11 of of ADP fnp-6284 8 12 the the DET fnp-6284 8 13 canadian canadian PROPN fnp-6284 8 14 association association NOUN fnp-6284 8 15 of of ADP fnp-6284 8 16 neuropathologists neuropathologist NOUN fnp-6284 8 17 – – PUNCT fnp-6284 8 18 association association PROPN fnp-6284 8 19 candienne candienne PROPN fnp-6284 8 20 des des PROPN fnp-6284 8 21 neuropathologistes neuropathologistes PROPN fnp-6284 8 22 ( ( PUNCT fnp-6284 8 23 canp canp NOUN fnp-6284 8 24 - - PUNCT fnp-6284 8 25 acnp acnp NOUN fnp-6284 8 26 ) ) PUNCT fnp-6284 8 27 in in ADP fnp-6284 8 28 october october PROPN fnp-6284 8 29 2024 2024 NUM fnp-6284 8 30 . . PUNCT fnp-6284 8 31     SPACE fnp-6284 9 1 https://doi.org/10.17879/freeneuropathology-2025-6284 https://doi.org/10.17879/freeneuropathology-2025-6284 NOUN fnp-6284 9 2 keywords keyword NOUN fnp-6284 9 3 : : PUNCT fnp-6284 9 4 canadian canadian ADJ fnp-6284 9 5 association association NOUN fnp-6284 9 6 of of ADP fnp-6284 9 7 neuropathologists neuropathologist NOUN fnp-6284 9 8 , , PUNCT fnp-6284 9 9 canp canp NOUN fnp-6284 9 10 , , PUNCT fnp-6284 9 11 meeting meet VERB fnp-6284 9 12 abstracts abstract NOUN fnp-6284 9 13 , , PUNCT fnp-6284 9 14 64th 64th ADJ fnp-6284 9 15 meeting meeting NOUN fnp-6284 9 16 oct oct PROPN fnp-6284 9 17 . . PROPN fnp-6284 9 18 2024 2024 NUM fnp-6284 9 19 contents content NOUN fnp-6284 9 20 abstract abstract NOUN fnp-6284 9 21     SPACE fnp-6284 9 22 1 1 NUM fnp-6284 9 23 : : PUNCT fnp-6284 9 24 distinctive distinctive ADJ fnp-6284 9 25 pattern pattern NOUN fnp-6284 9 26 of of ADP fnp-6284 9 27 cerebral cerebral ADJ fnp-6284 9 28 amyloid amyloid NOUN fnp-6284 9 29 angiopathy angiopathy NOUN fnp-6284 9 30 in in ADP fnp-6284 9 31 the the DET fnp-6284 9 32 cerebellum cerebellum ADJ fnp-6284 9 33 abstract abstract NOUN fnp-6284 9 34     SPACE fnp-6284 9 35 2 2 NUM fnp-6284 9 36 : : PUNCT fnp-6284 9 37 nigral nigral ADJ fnp-6284 9 38 astrocytic astrocytic ADJ fnp-6284 9 39 tau tau PROPN fnp-6284 9 40 pathology pathology NOUN fnp-6284 9 41 in in ADP fnp-6284 9 42 psp psp PROPN fnp-6284 9 43 abstract abstract NOUN fnp-6284 9 44     SPACE fnp-6284 9 45 3 3 NUM fnp-6284 9 46 : : PUNCT fnp-6284 9 47 keratan keratan ADJ fnp-6284 9 48 sulfate sulfate NOUN fnp-6284 9 49 is be AUX fnp-6284 9 50 a a DET fnp-6284 9 51 chemical chemical NOUN fnp-6284 9 52 template template NOUN fnp-6284 9 53 for for ADP fnp-6284 9 54 neuroblast neuroblast NOUN fnp-6284 9 55 migratory migratory NOUN fnp-6284 9 56 pathways pathway NOUN fnp-6284 9 57 and and CCONJ fnp-6284 9 58 axonal axonal ADJ fnp-6284 9 59 fascicles fascicle NOUN fnp-6284 9 60 in in ADP fnp-6284 9 61 human human ADJ fnp-6284 9 62 fetal fetal ADJ fnp-6284 9 63 forebrain forebrain NOUN fnp-6284 9 64 abstract abstract NOUN fnp-6284 9 65     SPACE fnp-6284 9 66 4 4 NUM fnp-6284 9 67 : : PUNCT fnp-6284 9 68 unique unique ADJ fnp-6284 9 69 neuropathological neuropathological ADJ fnp-6284 9 70 mechanisms mechanism NOUN fnp-6284 9 71 underlying underlie VERB fnp-6284 9 72 cognitive cognitive ADJ fnp-6284 9 73 impairment impairment NOUN fnp-6284 9 74 in in ADP fnp-6284 9 75 schizophrenia schizophrenia NOUN fnp-6284 9 76 abstract abstract NOUN fnp-6284 9 77     SPACE fnp-6284 9 78 5 5 NUM fnp-6284 9 79 : : PUNCT fnp-6284 9 80 recent recent ADJ fnp-6284 9 81 advances advance NOUN fnp-6284 9 82 in in ADP fnp-6284 9 83 spatial spatial ADJ fnp-6284 9 84 transcriptomics transcriptomic NOUN fnp-6284 9 85 of of ADP fnp-6284 9 86 the the DET fnp-6284 9 87 extracellular extracellular ADJ fnp-6284 9 88 matrix matrix NOUN fnp-6284 9 89 abstract abstract NOUN fnp-6284 9 90     SPACE fnp-6284 9 91 6 6 NUM fnp-6284 9 92 : : PUNCT fnp-6284 9 93 an an DET fnp-6284 9 94 anatomic anatomic ADJ fnp-6284 9 95 transcriptional transcriptional NOUN fnp-6284 9 96 atlas atla NOUN fnp-6284 9 97 of of ADP fnp-6284 9 98 focal focal ADJ fnp-6284 9 99 cortical cortical ADJ fnp-6284 9 100 dysplasia dysplasia NOUN fnp-6284 9 101 abstract abstract NOUN fnp-6284 9 102     SPACE fnp-6284 9 103 7 7 NUM fnp-6284 9 104 : : PUNCT fnp-6284 9 105 transcriptomic transcriptomic ADJ fnp-6284 9 106 profiling profiling NOUN fnp-6284 9 107 reveals reveal VERB fnp-6284 9 108 hippocampal hippocampal VERB fnp-6284 9 109 white white ADJ fnp-6284 9 110 matter matter NOUN fnp-6284 9 111 inflammation inflammation NOUN fnp-6284 9 112 as as ADP fnp-6284 9 113 potential potential ADJ fnp-6284 9 114 epileptogenic epileptogenic ADJ fnp-6284 9 115 focus focus NOUN fnp-6284 9 116 in in ADP fnp-6284 9 117 temporal temporal ADJ fnp-6284 9 118 lobe lobe ADJ fnp-6284 9 119 epilepsy epilepsy NOUN fnp-6284 9 120 abstract abstract ADJ fnp-6284 9 121     SPACE fnp-6284 9 122 8 8 NUM fnp-6284 9 123 : : PUNCT fnp-6284 9 124 global global ADJ fnp-6284 9 125 proteomics proteomic NOUN fnp-6284 9 126 reveals reveal VERB fnp-6284 9 127 bidirectional bidirectional ADJ fnp-6284 9 128 integrin integrin NOUN fnp-6284 9 129 signaling signal VERB fnp-6284 9 130 as as ADP fnp-6284 9 131 a a DET fnp-6284 9 132 driver driver NOUN fnp-6284 9 133 of of ADP fnp-6284 9 134 glioblastoma glioblastoma NOUN fnp-6284 9 135 invasion invasion NOUN fnp-6284 9 136 abstract abstract NOUN fnp-6284 9 137     SPACE fnp-6284 9 138 9 9 NUM fnp-6284 9 139 : : PUNCT fnp-6284 9 140 integration integration NOUN fnp-6284 9 141 of of ADP fnp-6284 9 142 molecular molecular ADJ fnp-6284 9 143 and and CCONJ fnp-6284 9 144 morphometric morphometric ADJ fnp-6284 9 145 features feature NOUN fnp-6284 9 146 improves improve VERB fnp-6284 9 147 prognostication prognostication NOUN fnp-6284 9 148 of of ADP fnp-6284 9 149 diffuse diffuse ADJ fnp-6284 9 150 gliomas glioma NOUN fnp-6284 9 151 abstract abstract ADJ fnp-6284 9 152     SPACE fnp-6284 9 153 10 10 NUM fnp-6284 9 154 : : PUNCT fnp-6284 9 155 a a DET fnp-6284 9 156 13 13 NUM fnp-6284 9 157 year year NOUN fnp-6284 9 158 review review NOUN fnp-6284 9 159 of of ADP fnp-6284 9 160 non non ADJ fnp-6284 9 161 - - ADJ fnp-6284 9 162 diffuse diffuse ADJ fnp-6284 9 163 large large ADJ fnp-6284 9 164 b b NOUN fnp-6284 9 165 cell cell NOUN fnp-6284 9 166 lymphomas lymphoma NOUN fnp-6284 9 167 of of ADP fnp-6284 9 168 the the DET fnp-6284 9 169 central central ADJ fnp-6284 9 170 nervous nervous ADJ fnp-6284 9 171 system system NOUN fnp-6284 9 172 at at ADP fnp-6284 9 173 a a DET fnp-6284 9 174 tertiary tertiary ADJ fnp-6284 9 175 hospital hospital NOUN fnp-6284 9 176 : : PUNCT fnp-6284 9 177 a a DET fnp-6284 9 178 case case NOUN fnp-6284 9 179 series series NOUN fnp-6284 9 180 study study NOUN fnp-6284 9 181 abstract abstract NOUN fnp-6284 9 182     SPACE fnp-6284 9 183 11 11 NUM fnp-6284 9 184 : : PUNCT fnp-6284 9 185 cost cost NOUN fnp-6284 9 186 - - PUNCT fnp-6284 9 187 benefit benefit NOUN fnp-6284 9 188 analysis analysis NOUN fnp-6284 9 189 of of ADP fnp-6284 9 190 fluorescence fluorescence NOUN fnp-6284 9 191 in in ADP fnp-6284 9 192 situ situ ADJ fnp-6284 9 193 hybridization hybridization NOUN fnp-6284 9 194 testing testing NOUN fnp-6284 9 195 in in ADP fnp-6284 9 196 the the DET fnp-6284 9 197 diagnosis diagnosis NOUN fnp-6284 9 198 of of ADP fnp-6284 9 199 idh idh NOUN fnp-6284 9 200 - - PUNCT fnp-6284 9 201 mutant mutant NOUN fnp-6284 9 202 1p/19q 1p/19q NOUN fnp-6284 9 203 - - PUNCT fnp-6284 9 204 codeleted codelete VERB fnp-6284 9 205 oligodendrogliomas oligodendroglioma NOUN fnp-6284 9 206 abstract abstract NOUN fnp-6284 9 207     SPACE fnp-6284 9 208 12 12 NUM fnp-6284 9 209 : : PUNCT fnp-6284 9 210 infant infant NOUN fnp-6284 9 211 - - PUNCT fnp-6284 9 212 type type NOUN fnp-6284 9 213 hemispheric hemispheric ADJ fnp-6284 9 214 glioma glioma NOUN fnp-6284 9 215 is be AUX fnp-6284 9 216 mostly mostly ADV fnp-6284 9 217 relatively relatively ADV fnp-6284 9 218 well well ADV fnp-6284 9 219 - - PUNCT fnp-6284 9 220 demarcated demarcate VERB fnp-6284 9 221 tumor tumor NOUN fnp-6284 9 222 and and CCONJ fnp-6284 9 223 not not PART fnp-6284 9 224 diffusely diffusely ADV fnp-6284 9 225 infiltrative infiltrative ADJ fnp-6284 9 226 abstract abstract NOUN fnp-6284 9 227     SPACE fnp-6284 9 228 13 13 NUM fnp-6284 9 229 : : PUNCT fnp-6284 9 230 features feature NOUN fnp-6284 9 231 of of ADP fnp-6284 9 232 central central ADJ fnp-6284 9 233 nervous nervous ADJ fnp-6284 9 234 system system NOUN fnp-6284 9 235 metastases metastasis NOUN fnp-6284 9 236 by by ADP fnp-6284 9 237 neoplasms neoplasm NOUN fnp-6284 9 238 of of ADP fnp-6284 9 239 gynecological gynecological ADJ fnp-6284 9 240 origin origin NOUN fnp-6284 9 241         SPACE fnp-6284 9 242 abstract abstract ADJ fnp-6284 9 243 1 1 NUM fnp-6284 9 244 free free ADJ fnp-6284 9 245 neuropathol neuropathol NOUN fnp-6284 9 246 6:1:4 6:1:4 DET fnp-6284 9 247 distinctive distinctive ADJ fnp-6284 9 248 pattern pattern NOUN fnp-6284 9 249 of of ADP fnp-6284 9 250 cerebral cerebral ADJ fnp-6284 9 251 amyloid amyloid NOUN fnp-6284 9 252 angiopathy angiopathy NOUN fnp-6284 9 253 in in ADP fnp-6284 9 254 the the DET fnp-6284 9 255 cerebellum cerebellum PROPN fnp-6284 9 256 david david PROPN fnp-6284 9 257 g. g. PROPN fnp-6284 9 258 munoz1,3 munoz1,3 PROPN fnp-6284 9 259 , , PUNCT fnp-6284 9 260 julia julia PROPN fnp-6284 9 261 keith2,3 keith2,3 PROPN fnp-6284 9 262 , , PUNCT fnp-6284 9 263 sara sara PROPN fnp-6284 9 264 mitchell4 mitchell4 PROPN fnp-6284 9 265 , , PUNCT fnp-6284 9 266 mario mario PROPN fnp-6284 9 267 masellis4 masellis4 PROPN fnp-6284 9 268 , , PUNCT fnp-6284 9 269 alyona alyona PROPN fnp-6284 9 270 ivanova5 ivanova5 PROPN fnp-6284 9 271 , , PUNCT fnp-6284 9 272 sandra sandra PROPN fnp-6284 9 273 black4 black4 PROPN fnp-6284 9 274 department department PROPN fnp-6284 9 275 of of ADP fnp-6284 9 276 laboratory laboratory NOUN fnp-6284 9 277 medicine medicine NOUN fnp-6284 9 278 , , PUNCT fnp-6284 9 279 st st PROPN fnp-6284 9 280 . . PROPN fnp-6284 9 281 michael michael PROPN fnp-6284 9 282 ’s ’s PART fnp-6284 9 283 hospital hospital NOUN fnp-6284 9 284 , , PUNCT fnp-6284 9 285 unity unity NOUN fnp-6284 9 286 health health PROPN fnp-6284 9 287 toronto toronto PROPN fnp-6284 9 288 , , PUNCT fnp-6284 9 289 toronto toronto PROPN fnp-6284 9 290 , , PUNCT fnp-6284 9 291 on on ADP fnp-6284 9 292 , , PUNCT fnp-6284 9 293 canada canada PROPN fnp-6284 9 294 department department PROPN fnp-6284 9 295 of of ADP fnp-6284 9 296 anatomic anatomic ADJ fnp-6284 9 297 pathology pathology NOUN fnp-6284 9 298 , , PUNCT fnp-6284 9 299 sunnybrook sunnybrook PROPN fnp-6284 9 300 health health PROPN fnp-6284 9 301 sciences sciences PROPN fnp-6284 9 302 center center PROPN fnp-6284 9 303 , , PUNCT fnp-6284 9 304 toronto toronto PROPN fnp-6284 9 305 , , PUNCT fnp-6284 9 306 on on ADP fnp-6284 9 307 , , PUNCT fnp-6284 9 308 canada canada PROPN fnp-6284 9 309 department department PROPN fnp-6284 9 310 of of ADP fnp-6284 9 311 laboratory laboratory PROPN fnp-6284 9 312 medicine medicine PROPN fnp-6284 9 313 & & CCONJ fnp-6284 9 314 pathobiology pathobiology NOUN fnp-6284 9 315 , , PUNCT fnp-6284 9 316 university university PROPN fnp-6284 9 317 of of ADP fnp-6284 9 318 toronto toronto PROPN fnp-6284 9 319 , , PUNCT fnp-6284 9 320 toronto toronto PROPN fnp-6284 9 321 , , PUNCT fnp-6284 9 322 on on ADP fnp-6284 9 323 , , PUNCT fnp-6284 9 324 canada canada PROPN fnp-6284 9 325 division division NOUN fnp-6284 9 326 of of ADP fnp-6284 9 327 neurology neurology NOUN fnp-6284 9 328 , , PUNCT fnp-6284 9 329 sunnybrook sunnybrook PROPN fnp-6284 9 330 health health PROPN fnp-6284 9 331 sciences sciences PROPN fnp-6284 9 332 center center PROPN fnp-6284 9 333 , , PUNCT fnp-6284 9 334 toronto toronto PROPN fnp-6284 9 335 , , PUNCT fnp-6284 9 336 on on ADP fnp-6284 9 337 , , PUNCT fnp-6284 9 338 canada canada PROPN fnp-6284 9 339 institute institute PROPN fnp-6284 9 340 of of ADP fnp-6284 9 341 medical medical ADJ fnp-6284 9 342 science science NOUN fnp-6284 9 343 , , PUNCT fnp-6284 9 344 university university PROPN fnp-6284 9 345 of of ADP fnp-6284 9 346 toronto toronto PROPN fnp-6284 9 347 , , PUNCT fnp-6284 9 348 toronto toronto PROPN fnp-6284 9 349 , , PUNCT fnp-6284 9 350 on on ADV fnp-6284 9 351 , , PUNCT fnp-6284 9 352 canada canada PROPN fnp-6284 9 353 we we PRON fnp-6284 9 354 aimed aim VERB fnp-6284 9 355 to to PART fnp-6284 9 356 compare compare VERB fnp-6284 9 357 the the DET fnp-6284 9 358 patterns pattern NOUN fnp-6284 9 359 of of ADP fnp-6284 9 360 cerebral cerebral ADJ fnp-6284 9 361 amyloid amyloid NOUN fnp-6284 9 362 angiopathy angiopathy ADJ fnp-6284 9 363 ( ( PUNCT fnp-6284 9 364 caa caa NOUN fnp-6284 9 365 ) ) PUNCT fnp-6284 9 366 in in ADP fnp-6284 9 367 the the DET fnp-6284 9 368 cerebral cerebral ADJ fnp-6284 9 369 and and CCONJ fnp-6284 9 370 cerebellar cerebellar ADJ fnp-6284 9 371 cortices cortex NOUN fnp-6284 9 372 . . PUNCT fnp-6284 10 1 we we PRON fnp-6284 10 2 studied study VERB fnp-6284 10 3 24 24 NUM fnp-6284 10 4 brains brain NOUN fnp-6284 10 5 from from ADP fnp-6284 10 6 the the DET fnp-6284 10 7 pathology pathology NOUN fnp-6284 10 8 departmental departmental ADJ fnp-6284 10 9 archives archive NOUN fnp-6284 10 10 at at ADP fnp-6284 10 11 sunnybrook sunnybrook PROPN fnp-6284 10 12 , , PUNCT fnp-6284 10 13 ages age NOUN fnp-6284 10 14 56–93 56–93 NUM fnp-6284 10 15 . . PUNCT fnp-6284 11 1 diagnoses diagnosis NOUN fnp-6284 11 2 included include VERB fnp-6284 11 3 alzheimer alzheimer PROPN fnp-6284 11 4 ’s ’s PART fnp-6284 11 5 disease disease NOUN fnp-6284 11 6 and and CCONJ fnp-6284 11 7 vascular vascular ADJ fnp-6284 11 8 dementia dementia NOUN fnp-6284 11 9 . . PUNCT fnp-6284 12 1 meningeal meningeal ADJ fnp-6284 12 2 , , PUNCT fnp-6284 12 3 parenchymal parenchymal ADJ fnp-6284 12 4 , , PUNCT fnp-6284 12 5 and and CCONJ fnp-6284 12 6 capillary capillary ADJ fnp-6284 12 7 caa caa NOUN fnp-6284 12 8 were be AUX fnp-6284 12 9 evaluated evaluate VERB fnp-6284 12 10 in in ADP fnp-6284 12 11 frontal frontal ADJ fnp-6284 12 12 , , PUNCT fnp-6284 12 13 occipital occipital NOUN fnp-6284 12 14 , , PUNCT fnp-6284 12 15 and and CCONJ fnp-6284 12 16 basal basal VERB fnp-6284 12 17 temporal temporal ADJ fnp-6284 12 18 cortices cortex NOUN fnp-6284 12 19 , , PUNCT fnp-6284 12 20 and and CCONJ fnp-6284 12 21 cerebellum cerebellum PROPN fnp-6284 12 22 . . PUNCT fnp-6284 13 1 caa caa NOUN fnp-6284 13 2 and and CCONJ fnp-6284 13 3 plaques plaque NOUN fnp-6284 13 4 were be AUX fnp-6284 13 5 scored score VERB fnp-6284 13 6 0–3 0–3 PUNCT fnp-6284 13 7 as as ADP fnp-6284 13 8 per per ADP fnp-6284 13 9 love love NOUN fnp-6284 13 10 2014 2014 NUM fnp-6284 13 11 . . PUNCT fnp-6284 14 1 caa caa PROPN fnp-6284 14 2 was be AUX fnp-6284 14 3 identified identify VERB fnp-6284 14 4 in in ADP fnp-6284 14 5 21/24 21/24 NUM fnp-6284 14 6 cases case NOUN fnp-6284 14 7 . . PUNCT fnp-6284 15 1 cerebellum cerebellum NOUN fnp-6284 15 2 caa caa NOUN fnp-6284 15 3 was be AUX fnp-6284 15 4 present present ADJ fnp-6284 15 5 in in ADP fnp-6284 15 6 17/24 17/24 NUM fnp-6284 15 7 cases case NOUN fnp-6284 15 8 ; ; PUNCT fnp-6284 15 9 it it PRON fnp-6284 15 10 was be AUX fnp-6284 15 11 never never ADV fnp-6284 15 12 present present ADJ fnp-6284 15 13 without without ADP fnp-6284 15 14 some some DET fnp-6284 15 15 caa caa NOUN fnp-6284 15 16 in in ADP fnp-6284 15 17 one one NUM fnp-6284 15 18 of of ADP fnp-6284 15 19 the the DET fnp-6284 15 20 neocortical neocortical ADJ fnp-6284 15 21 regions region NOUN fnp-6284 15 22 . . PUNCT fnp-6284 16 1 however however ADV fnp-6284 16 2 , , PUNCT fnp-6284 16 3 the the DET fnp-6284 16 4 cerebellar cerebellar PROPN fnp-6284 16 5 caa caa PROPN fnp-6284 16 6 score score NOUN fnp-6284 16 7 exceeded exceed VERB fnp-6284 16 8 the the DET fnp-6284 16 9 score score NOUN fnp-6284 16 10 in in ADP fnp-6284 16 11 any any DET fnp-6284 16 12 neocortical neocortical ADJ fnp-6284 16 13 region region NOUN fnp-6284 16 14 in in ADP fnp-6284 16 15 4 4 NUM fnp-6284 16 16 cases case NOUN fnp-6284 16 17 , , PUNCT fnp-6284 16 18 was be AUX fnp-6284 16 19 equal equal ADJ fnp-6284 16 20 in in ADP fnp-6284 16 21 9 9 NUM fnp-6284 16 22 , , PUNCT fnp-6284 16 23 and and CCONJ fnp-6284 16 24 less less ADJ fnp-6284 16 25 than than ADP fnp-6284 16 26 at at ADV fnp-6284 16 27 least least ADV fnp-6284 16 28 one one NUM fnp-6284 16 29 neocortical neocortical ADJ fnp-6284 16 30 region region NOUN fnp-6284 16 31 in in ADP fnp-6284 16 32 7 7 NUM fnp-6284 16 33 . . PUNCT fnp-6284 17 1 in in ADP fnp-6284 17 2 the the DET fnp-6284 17 3 cerebellum cerebellum ADJ fnp-6284 17 4 meningeal meningeal NOUN fnp-6284 17 5 exceeded exceed VERB fnp-6284 17 6 parenchymal parenchymal ADJ fnp-6284 17 7 scores score NOUN fnp-6284 17 8 in in ADP fnp-6284 17 9 12 12 NUM fnp-6284 17 10 cases case NOUN fnp-6284 17 11 , , PUNCT fnp-6284 17 12 and and CCONJ fnp-6284 17 13 parenchymal parenchymal ADJ fnp-6284 17 14 exceeded exceed VERB fnp-6284 17 15 meningeal meningeal NOUN fnp-6284 17 16 in in ADP fnp-6284 17 17 5 5 NUM fnp-6284 17 18 cases case NOUN fnp-6284 17 19 . . PUNCT fnp-6284 18 1 cerebellar cerebellar PROPN fnp-6284 18 2 caa caa PROPN fnp-6284 18 3 with with ADP fnp-6284 18 4 scores score NOUN fnp-6284 18 5 of of ADP fnp-6284 18 6 up up ADP fnp-6284 18 7 to to PART fnp-6284 18 8 3 3 NUM fnp-6284 18 9 was be AUX fnp-6284 18 10 present present ADJ fnp-6284 18 11 in in ADP fnp-6284 18 12 cases case NOUN fnp-6284 18 13 without without ADP fnp-6284 18 14 cerebellar cerebellar ADJ fnp-6284 18 15 plaques plaque NOUN fnp-6284 18 16 ; ; PUNCT fnp-6284 18 17 likewise likewise ADV fnp-6284 18 18 cerebellar cerebellar ADJ fnp-6284 18 19 plaque plaque NOUN fnp-6284 18 20 scores score NOUN fnp-6284 18 21 of of ADP fnp-6284 18 22 2 2 NUM fnp-6284 18 23 were be AUX fnp-6284 18 24 present present ADJ fnp-6284 18 25 in in ADP fnp-6284 18 26 a a DET fnp-6284 18 27 case case NOUN fnp-6284 18 28 without without ADP fnp-6284 18 29 cerebellar cerebellar PROPN fnp-6284 18 30 caa caa NOUN fnp-6284 18 31 . . PUNCT fnp-6284 19 1 there there PRON fnp-6284 19 2 never never ADV fnp-6284 19 3 was be AUX fnp-6284 19 4 capillary capillary ADJ fnp-6284 19 5 caa caa NOUN fnp-6284 19 6 in in ADP fnp-6284 19 7 the the DET fnp-6284 19 8 absence absence NOUN fnp-6284 19 9 of of ADP fnp-6284 19 10 parenchymal parenchymal ADJ fnp-6284 19 11 caa caa NOUN fnp-6284 19 12 in in ADP fnp-6284 19 13 any any DET fnp-6284 19 14 region region NOUN fnp-6284 19 15 . . PUNCT fnp-6284 20 1 there there PRON fnp-6284 20 2 was be VERB fnp-6284 20 3 no no DET fnp-6284 20 4 correlation correlation NOUN fnp-6284 20 5 between between ADP fnp-6284 20 6 meningeal meningeal ADJ fnp-6284 20 7 and and CCONJ fnp-6284 20 8 parenchymal parenchymal ADJ fnp-6284 20 9 caa caa NOUN fnp-6284 20 10 scores score NOUN fnp-6284 20 11 in in ADP fnp-6284 20 12 the the DET fnp-6284 20 13 cerebellum cerebellum NOUN fnp-6284 20 14 , , PUNCT fnp-6284 20 15 whereas whereas SCONJ fnp-6284 20 16 they they PRON fnp-6284 20 17 were be AUX fnp-6284 20 18 highly highly ADV fnp-6284 20 19 correlated correlate VERB fnp-6284 20 20 in in ADP fnp-6284 20 21 neocortical neocortical ADJ fnp-6284 20 22 areas area NOUN fnp-6284 20 23 . . PUNCT fnp-6284 21 1 we we PRON fnp-6284 21 2 conclude conclude VERB fnp-6284 21 3 that that SCONJ fnp-6284 21 4 cerebellar cerebellar PROPN fnp-6284 21 5 caa caa NOUN fnp-6284 21 6 is be AUX fnp-6284 21 7 common common ADJ fnp-6284 21 8 , , PUNCT fnp-6284 21 9 often often ADV fnp-6284 21 10 equal equal ADJ fnp-6284 21 11 or or CCONJ fnp-6284 21 12 more more ADV fnp-6284 21 13 severe severe ADJ fnp-6284 21 14 than than ADP fnp-6284 21 15 neocortical neocortical ADJ fnp-6284 21 16 caa caa NOUN fnp-6284 21 17 . . PUNCT fnp-6284 22 1 in in ADP fnp-6284 22 2 the the DET fnp-6284 22 3 cerebellum cerebellum NOUN fnp-6284 22 4 , , PUNCT fnp-6284 22 5 unlike unlike ADP fnp-6284 22 6 in in ADP fnp-6284 22 7 the the DET fnp-6284 22 8 neocortex neocortex NOUN fnp-6284 22 9 , , PUNCT fnp-6284 22 10 meningeal meningeal ADJ fnp-6284 22 11 and and CCONJ fnp-6284 22 12 parenchymal parenchymal ADJ fnp-6284 22 13 caa caa NOUN fnp-6284 22 14 are be AUX fnp-6284 22 15 not not PART fnp-6284 22 16 correlated correlate VERB fnp-6284 22 17 , , PUNCT fnp-6284 22 18 suggesting suggest VERB fnp-6284 22 19 that that SCONJ fnp-6284 22 20 they they PRON fnp-6284 22 21 are be AUX fnp-6284 22 22 responses response NOUN fnp-6284 22 23 to to ADP fnp-6284 22 24 largely largely ADV fnp-6284 22 25 independent independent ADJ fnp-6284 22 26 pathophysiological pathophysiological ADJ fnp-6284 22 27 mechanisms mechanism NOUN fnp-6284 22 28 . . PUNCT fnp-6284 22 29     SPACE fnp-6284 23 1 abstract abstract ADJ fnp-6284 23 2 2 2 NUM fnp-6284 23 3 free free ADJ fnp-6284 23 4 neuropathol neuropathol NOUN fnp-6284 23 5 6:1:5 6:1:5 NUM fnp-6284 23 6 nigral nigral ADJ fnp-6284 23 7 astrocytic astrocytic ADJ fnp-6284 23 8 tau tau PROPN fnp-6284 23 9 pathology pathology NOUN fnp-6284 23 10 in in ADP fnp-6284 23 11 psp psp PROPN fnp-6284 23 12 hidetomo hidetomo ADV fnp-6284 23 13 tanaka1 tanaka1 PROPN fnp-6284 23 14 , , PUNCT fnp-6284 23 15 seojin seojin PROPN fnp-6284 23 16 lee1 lee1 PROPN fnp-6284 23 17 , , PUNCT fnp-6284 23 18 shelley shelley PROPN fnp-6284 23 19 l. l. PROPN fnp-6284 23 20 forrest1 forrest1 PROPN fnp-6284 23 21 , , PUNCT fnp-6284 23 22 gabor gabor PROPN fnp-6284 23 23 g. g. PROPN fnp-6284 23 24 kovacs1 kovacs1 PROPN fnp-6284 24 1 department department PROPN fnp-6284 24 2 of of ADP fnp-6284 24 3 laboratory laboratory NOUN fnp-6284 24 4 medicine medicine NOUN fnp-6284 24 5 and and CCONJ fnp-6284 24 6 pathobiology pathobiology NOUN fnp-6284 24 7 and and CCONJ fnp-6284 24 8 tanz tanz NOUN fnp-6284 24 9 centre centre NOUN fnp-6284 24 10 for for ADP fnp-6284 24 11 research research NOUN fnp-6284 24 12 in in ADP fnp-6284 24 13 neurodegenerative neurodegenerative ADJ fnp-6284 24 14 disease disease NOUN fnp-6284 24 15 , , PUNCT fnp-6284 24 16 university university PROPN fnp-6284 24 17 of of ADP fnp-6284 24 18 toronto toronto PROPN fnp-6284 24 19 , , PUNCT fnp-6284 24 20 toronto toronto PROPN fnp-6284 24 21 , , PUNCT fnp-6284 24 22 on on ADP fnp-6284 24 23 , , PUNCT fnp-6284 24 24 canada canada PROPN fnp-6284 24 25 background background NOUN fnp-6284 24 26 : : PUNCT fnp-6284 24 27 astrocytic astrocytic ADJ fnp-6284 24 28 tau tau PROPN fnp-6284 24 29 pathology pathology NOUN fnp-6284 24 30 is be AUX fnp-6284 24 31 a a DET fnp-6284 24 32 major major ADJ fnp-6284 24 33 feature feature NOUN fnp-6284 24 34 of of ADP fnp-6284 24 35 primary primary ADJ fnp-6284 24 36 tauopathies tauopathie NOUN fnp-6284 24 37 and and CCONJ fnp-6284 24 38 aging age VERB fnp-6284 24 39 - - PUNCT fnp-6284 24 40 related relate VERB fnp-6284 24 41 tau tau PROPN fnp-6284 24 42 astrogliopathy astrogliopathy ADJ fnp-6284 24 43 ( ( PUNCT fnp-6284 24 44 artag artag ADJ fnp-6284 24 45 ) ) PUNCT fnp-6284 24 46 . . PUNCT fnp-6284 25 1 although although SCONJ fnp-6284 25 2 tau tau PROPN fnp-6284 25 3 pathology pathology NOUN fnp-6284 25 4 in in ADP fnp-6284 25 5 the the DET fnp-6284 25 6 substantia substantia NOUN fnp-6284 25 7 nigra nigra NOUN fnp-6284 25 8 ( ( PUNCT fnp-6284 25 9 sn sn PROPN fnp-6284 25 10 ) ) PUNCT fnp-6284 25 11 is be AUX fnp-6284 25 12 usually usually ADV fnp-6284 25 13 neuronal neuronal ADJ fnp-6284 25 14 , , PUNCT fnp-6284 25 15 we we PRON fnp-6284 25 16 recently recently ADV fnp-6284 25 17 reported report VERB fnp-6284 25 18 cases case NOUN fnp-6284 25 19 with with ADP fnp-6284 25 20 prominent prominent ADJ fnp-6284 25 21 nigral nigral ADJ fnp-6284 25 22 tau tau PROPN fnp-6284 25 23 astrogliopathy astrogliopathy ADJ fnp-6284 25 24 ( ( PUNCT fnp-6284 25 25 nitag nitag NOUN fnp-6284 25 26 ) ) PUNCT fnp-6284 25 27 . . PUNCT fnp-6284 26 1 interestingly interestingly ADV fnp-6284 26 2 , , PUNCT fnp-6284 26 3 despite despite SCONJ fnp-6284 26 4 diverse diverse ADJ fnp-6284 26 5 primary primary ADJ fnp-6284 26 6 diseases disease NOUN fnp-6284 26 7 , , PUNCT fnp-6284 26 8 nitag nitag NOUN fnp-6284 26 9 exhibited exhibit VERB fnp-6284 26 10 shared share VERB fnp-6284 26 11 distinctive distinctive ADJ fnp-6284 26 12 features feature NOUN fnp-6284 26 13 : : PUNCT fnp-6284 26 14 abundant abundant ADJ fnp-6284 26 15 tau tau ADJ fnp-6284 26 16 - - PUNCT fnp-6284 26 17 positive positive ADJ fnp-6284 26 18 astrocytes astrocyte NOUN fnp-6284 26 19 with with ADP fnp-6284 26 20 fewer few ADJ fnp-6284 26 21 tau tau ADJ fnp-6284 26 22 - - PUNCT fnp-6284 26 23 positive positive ADJ fnp-6284 26 24 neuronal neuronal ADJ fnp-6284 26 25 cytoplasmic cytoplasmic ADJ fnp-6284 26 26 inclusions inclusion NOUN fnp-6284 26 27 ( ( PUNCT fnp-6284 26 28 ncis ncis NOUN fnp-6284 26 29 ) ) PUNCT fnp-6284 26 30 and and CCONJ fnp-6284 26 31 mild mild ADJ fnp-6284 26 32 neuronal neuronal ADJ fnp-6284 26 33 loss loss NOUN fnp-6284 26 34 in in ADP fnp-6284 26 35 the the DET fnp-6284 26 36 sn sn NOUN fnp-6284 26 37 , , PUNCT fnp-6284 26 38 and and CCONJ fnp-6284 26 39 some some DET fnp-6284 26 40 astrocytic astrocytic ADJ fnp-6284 26 41 lesions lesion NOUN fnp-6284 26 42 in in ADP fnp-6284 26 43 the the DET fnp-6284 26 44 other other ADJ fnp-6284 26 45 brainstem brainstem NOUN fnp-6284 26 46 regions region NOUN fnp-6284 26 47 . . PUNCT fnp-6284 27 1 method method NOUN fnp-6284 27 2 : : PUNCT fnp-6284 27 3 we we PRON fnp-6284 27 4 investigated investigate VERB fnp-6284 27 5 the the DET fnp-6284 27 6 nigral nigral ADJ fnp-6284 27 7 astrocytic astrocytic ADJ fnp-6284 27 8 tau tau PROPN fnp-6284 27 9 pathology pathology NOUN fnp-6284 27 10 in in ADP fnp-6284 27 11 39 39 NUM fnp-6284 27 12 progressive progressive ADJ fnp-6284 27 13 supranuclear supranuclear ADJ fnp-6284 27 14 palsy palsy ADJ fnp-6284 27 15 ( ( PUNCT fnp-6284 27 16 psp psp NOUN fnp-6284 27 17 ) ) PUNCT fnp-6284 27 18 cases case NOUN fnp-6284 27 19 . . PUNCT fnp-6284 28 1 results result NOUN fnp-6284 28 2 : : PUNCT fnp-6284 28 3 compared compare VERB fnp-6284 28 4 to to ADP fnp-6284 28 5 the the DET fnp-6284 28 6 cases case NOUN fnp-6284 28 7 with with ADP fnp-6284 28 8 prominent prominent ADJ fnp-6284 28 9 nitag nitag NOUN fnp-6284 28 10 , , PUNCT fnp-6284 28 11 the the DET fnp-6284 28 12 severity severity NOUN fnp-6284 28 13 of of ADP fnp-6284 28 14 nigral nigral ADJ fnp-6284 28 15 astroglial astroglial ADJ fnp-6284 28 16 tau tau PROPN fnp-6284 28 17 pathology pathology NOUN fnp-6284 28 18 was be AUX fnp-6284 28 19 not not PART fnp-6284 28 20 as as ADV fnp-6284 28 21 high high ADJ fnp-6284 28 22 and and CCONJ fnp-6284 28 23 was be AUX fnp-6284 28 24 present present ADJ fnp-6284 28 25 in in ADP fnp-6284 28 26 36 36 NUM fnp-6284 28 27 of of ADP fnp-6284 28 28 the the DET fnp-6284 28 29 39 39 NUM fnp-6284 28 30 psp psp NOUN fnp-6284 28 31 cases case NOUN fnp-6284 28 32 , , PUNCT fnp-6284 28 33 with with ADP fnp-6284 28 34 varying vary VERB fnp-6284 28 35 amounts amount NOUN fnp-6284 28 36 . . PUNCT fnp-6284 29 1 we we PRON fnp-6284 29 2 classified classify VERB fnp-6284 29 3 psp psp NOUN fnp-6284 29 4 cases case NOUN fnp-6284 29 5 into into ADP fnp-6284 29 6 high high ADJ fnp-6284 29 7 and and CCONJ fnp-6284 29 8 low low ADJ fnp-6284 29 9 groups group NOUN fnp-6284 29 10 based base VERB fnp-6284 29 11 on on ADP fnp-6284 29 12 the the DET fnp-6284 29 13 number number NOUN fnp-6284 29 14 of of ADP fnp-6284 29 15 tau tau NOUN fnp-6284 29 16 - - PUNCT fnp-6284 29 17 positive positive ADJ fnp-6284 29 18 astrocytes astrocyte NOUN fnp-6284 29 19 in in ADP fnp-6284 29 20 the the DET fnp-6284 29 21 sn sn PROPN fnp-6284 29 22 and and CCONJ fnp-6284 29 23 compared compare VERB fnp-6284 29 24 clinicopathological clinicopathological ADJ fnp-6284 29 25 features feature NOUN fnp-6284 29 26 . . PUNCT fnp-6284 30 1 morphologically morphologically ADV fnp-6284 30 2 , , PUNCT fnp-6284 30 3 nigral nigral ADJ fnp-6284 30 4 tau tau PROPN fnp-6284 30 5 - - PUNCT fnp-6284 30 6 positive positive ADJ fnp-6284 30 7 astrocytes astrocyte NOUN fnp-6284 30 8 in in ADP fnp-6284 30 9 psp psp NOUN fnp-6284 30 10 were be AUX fnp-6284 30 11 distinct distinct ADJ fnp-6284 30 12 from from ADP fnp-6284 30 13 typical typical ADJ fnp-6284 30 14 tufted tufte VERB fnp-6284 30 15 astrocytes astrocyte NOUN fnp-6284 30 16 and and CCONJ fnp-6284 30 17 resembled resemble VERB fnp-6284 30 18 those those PRON fnp-6284 30 19 seen see VERB fnp-6284 30 20 in in ADP fnp-6284 30 21 nitag nitag NOUN fnp-6284 30 22 . . PUNCT fnp-6284 31 1 unlike unlike ADP fnp-6284 31 2 nitag nitag NOUN fnp-6284 31 3 , , PUNCT fnp-6284 31 4 both both DET fnp-6284 31 5 groups group NOUN fnp-6284 31 6 exhibited exhibit VERB fnp-6284 31 7 more more ADJ fnp-6284 31 8 than than ADP fnp-6284 31 9 moderate moderate ADJ fnp-6284 31 10 neuronal neuronal ADJ fnp-6284 31 11 loss loss NOUN fnp-6284 31 12 and and CCONJ fnp-6284 31 13 ncis ncis NOUN fnp-6284 31 14 in in ADP fnp-6284 31 15 the the DET fnp-6284 31 16 sn sn NOUN fnp-6284 31 17 , , PUNCT fnp-6284 31 18 with with ADP fnp-6284 31 19 no no DET fnp-6284 31 20 significant significant ADJ fnp-6284 31 21 difference difference NOUN fnp-6284 31 22 . . PUNCT fnp-6284 32 1 however however ADV fnp-6284 32 2 , , PUNCT fnp-6284 32 3 the the DET fnp-6284 32 4 extent extent NOUN fnp-6284 32 5 of of ADP fnp-6284 32 6 tau tau NOUN fnp-6284 32 7 - - PUNCT fnp-6284 32 8 positive positive ADJ fnp-6284 32 9 astrocytes astrocyte NOUN fnp-6284 32 10 in in ADP fnp-6284 32 11 midbrain midbrain NOUN fnp-6284 32 12 regions region NOUN fnp-6284 32 13 outside outside ADP fnp-6284 32 14 the the DET fnp-6284 32 15 sn sn PROPN fnp-6284 32 16 was be AUX fnp-6284 32 17 significantly significantly ADV fnp-6284 32 18 higher high ADJ fnp-6284 32 19 in in ADP fnp-6284 32 20 the the DET fnp-6284 32 21 high high ADJ fnp-6284 32 22 - - PUNCT fnp-6284 32 23 group group NOUN fnp-6284 32 24 . . PUNCT fnp-6284 33 1 conclusion conclusion NOUN fnp-6284 33 2 : : PUNCT fnp-6284 33 3 we we PRON fnp-6284 33 4 stratified stratify VERB fnp-6284 33 5 psp psp NOUN fnp-6284 33 6 cases case NOUN fnp-6284 33 7 based base VERB fnp-6284 33 8 on on ADP fnp-6284 33 9 the the DET fnp-6284 33 10 presence presence NOUN fnp-6284 33 11 and and CCONJ fnp-6284 33 12 severity severity NOUN fnp-6284 33 13 of of ADP fnp-6284 33 14 nitag nitag NOUN fnp-6284 33 15 - - PUNCT fnp-6284 33 16 type type NOUN fnp-6284 33 17 pathology pathology NOUN fnp-6284 33 18 and and CCONJ fnp-6284 33 19 identified identify VERB fnp-6284 33 20 distinct distinct ADJ fnp-6284 33 21 features feature NOUN fnp-6284 33 22 supporting support VERB fnp-6284 33 23 the the DET fnp-6284 33 24 notion notion NOUN fnp-6284 33 25 that that SCONJ fnp-6284 33 26 psp psp NOUN fnp-6284 33 27 might might AUX fnp-6284 33 28 have have AUX fnp-6284 33 29 different different ADJ fnp-6284 33 30 pathological pathological ADJ fnp-6284 33 31 subtypes subtype NOUN fnp-6284 33 32 eventually eventually ADV fnp-6284 33 33 reflect reflect VERB fnp-6284 33 34 distinct distinct ADJ fnp-6284 33 35 pathogenesis pathogenesis NOUN fnp-6284 33 36 . . PUNCT fnp-6284 33 37     SPACE fnp-6284 34 1 abstract abstract ADJ fnp-6284 34 2 3 3 NUM fnp-6284 34 3 free free ADJ fnp-6284 34 4 neuropathol neuropathol NOUN fnp-6284 34 5 6:1:6 6:1:6 NUM fnp-6284 34 6 keratan keratan PROPN fnp-6284 34 7 sulfate sulfate NOUN fnp-6284 34 8 is be AUX fnp-6284 34 9 a a DET fnp-6284 34 10 chemical chemical NOUN fnp-6284 34 11 template template NOUN fnp-6284 34 12 for for ADP fnp-6284 34 13 neuroblast neuroblast NOUN fnp-6284 34 14 migratory migratory NOUN fnp-6284 34 15 pathways pathway NOUN fnp-6284 34 16 and and CCONJ fnp-6284 34 17 axonal axonal ADJ fnp-6284 34 18 fascicles fascicle NOUN fnp-6284 34 19 in in ADP fnp-6284 34 20 human human ADJ fnp-6284 34 21 fetal fetal ADJ fnp-6284 34 22 forebrain forebrain NOUN fnp-6284 34 23 harvey harvey PROPN fnp-6284 34 24 b. b. PROPN fnp-6284 34 25 sarnat1,2 sarnat1,2 PROPN fnp-6284 34 26 , , PUNCT fnp-6284 34 27 weiming weime VERB fnp-6284 34 28 yu3 yu3 NOUN fnp-6284 34 29 departments department NOUN fnp-6284 34 30 of of ADP fnp-6284 34 31 paediatrics paediatric NOUN fnp-6284 34 32 , , PUNCT fnp-6284 34 33 pathology pathology NOUN fnp-6284 34 34 ( ( PUNCT fnp-6284 34 35 neuropathology neuropathology NOUN fnp-6284 34 36 ) ) PUNCT fnp-6284 34 37 and and CCONJ fnp-6284 34 38 clinical clinical ADJ fnp-6284 34 39 neurosciences neuroscience NOUN fnp-6284 34 40 , , PUNCT fnp-6284 34 41 university university NOUN fnp-6284 34 42 of of ADP fnp-6284 34 43 calgary calgary PROPN fnp-6284 34 44 cumming cumming PROPN fnp-6284 34 45 school school NOUN fnp-6284 34 46 of of ADP fnp-6284 34 47 medicine medicine NOUN fnp-6284 34 48 , , PUNCT fnp-6284 34 49 calgary calgary PROPN fnp-6284 34 50 , , PUNCT fnp-6284 34 51 alberta alberta PROPN fnp-6284 34 52 , , PUNCT fnp-6284 34 53 canada canada PROPN fnp-6284 34 54 alberta alberta PROPN fnp-6284 34 55 children children PROPN fnp-6284 34 56 ’s ’s PART fnp-6284 34 57 hospital hospital PROPN fnp-6284 34 58 research research PROPN fnp-6284 34 59 institute institute PROPN fnp-6284 34 60 ( ( PUNCT fnp-6284 34 61 owerko owerko PROPN fnp-6284 34 62 centre centre PROPN fnp-6284 34 63 ) ) PUNCT fnp-6284 34 64 , , PUNCT fnp-6284 34 65 calgary calgary PROPN fnp-6284 34 66 , , PUNCT fnp-6284 34 67 alberta alberta PROPN fnp-6284 34 68 , , PUNCT fnp-6284 34 69 canada canada PROPN fnp-6284 34 70 department department PROPN fnp-6284 34 71 of of ADP fnp-6284 34 72 pathology pathology PROPN fnp-6284 34 73 and and CCONJ fnp-6284 34 74 laboratory laboratory NOUN fnp-6284 34 75 medicine medicine NOUN fnp-6284 34 76 , , PUNCT fnp-6284 34 77 alberta alberta PROPN fnp-6284 34 78 children children PROPN fnp-6284 34 79 ’s ’s PART fnp-6284 34 80 hospital hospital NOUN fnp-6284 34 81 , , PUNCT fnp-6284 34 82 calgary calgary PROPN fnp-6284 34 83 , , PUNCT fnp-6284 34 84 alberta alberta PROPN fnp-6284 34 85 , , PUNCT fnp-6284 34 86 canada canada PROPN fnp-6284 34 87 objectives objective VERB fnp-6284 34 88 . . PUNCT fnp-6284 35 1 timing timing NOUN fnp-6284 35 2 of of ADP fnp-6284 35 3 keratan keratan ADJ fnp-6284 35 4 sulfate sulfate NOUN fnp-6284 35 5 ( ( PUNCT fnp-6284 35 6 ks ks NOUN fnp-6284 35 7 ) ) PUNCT fnp-6284 35 8 during during ADP fnp-6284 35 9 morphogenesis morphogenesis NOUN fnp-6284 35 10 in in ADP fnp-6284 35 11 normally normally ADV fnp-6284 35 12 developing develop VERB fnp-6284 35 13 human human ADJ fnp-6284 35 14 fetal fetal ADJ fnp-6284 35 15 forebrain forebrain NOUN fnp-6284 35 16 structures structure NOUN fnp-6284 35 17 was be AUX fnp-6284 35 18 studied study VERB fnp-6284 35 19 . . PUNCT fnp-6284 36 1 ks k NOUN fnp-6284 36 2 is be AUX fnp-6284 36 3 a a DET fnp-6284 36 4 proteoglycan proteoglycan NOUN fnp-6284 36 5 secreted secrete VERB fnp-6284 36 6 in in ADP fnp-6284 36 7 fetal fetal ADJ fnp-6284 36 8 brain brain NOUN fnp-6284 36 9 by by ADP fnp-6284 36 10 astrocytes astrocyte NOUN fnp-6284 36 11 and and CCONJ fnp-6284 36 12 radial radial ADJ fnp-6284 36 13 glia glia NOUN fnp-6284 36 14 into into ADP fnp-6284 36 15 extracellular extracellular ADJ fnp-6284 36 16 parenchyma parenchyma NOUN fnp-6284 36 17 as as ADP fnp-6284 36 18 granulofilamentous granulofilamentous ADJ fnp-6284 36 19 deposits deposit NOUN fnp-6284 36 20 . . PUNCT fnp-6284 37 1 it it PRON fnp-6284 37 2 envelops envelop VERB fnp-6284 37 3 neurons neuron NOUN fnp-6284 37 4 except except SCONJ fnp-6284 37 5 dendritic dendritic ADJ fnp-6284 37 6 spines spine NOUN fnp-6284 37 7 , , PUNCT fnp-6284 37 8 repels repel VERB fnp-6284 37 9 glutamatergic glutamatergic ADJ fnp-6284 37 10 and and CCONJ fnp-6284 37 11 facilitates facilitate VERB fnp-6284 37 12 gabaergic gabaergic ADJ fnp-6284 37 13 axons axon NOUN fnp-6284 37 14 . . PUNCT fnp-6284 38 1 the the DET fnp-6284 38 2 same same ADJ fnp-6284 38 3 genes gene NOUN fnp-6284 38 4 are be AUX fnp-6284 38 5 expressed express VERB fnp-6284 38 6 in in ADP fnp-6284 38 7 both both PRON fnp-6284 38 8 neuroblast neuroblast NOUN fnp-6284 38 9 migration migration NOUN fnp-6284 38 10 and and CCONJ fnp-6284 38 11 axonal axonal ADJ fnp-6284 38 12 growth growth NOUN fnp-6284 38 13 . . PUNCT fnp-6284 39 1 methods method NOUN fnp-6284 39 2 . . PUNCT fnp-6284 40 1 twenty twenty NUM fnp-6284 40 2 normal normal ADJ fnp-6284 40 3 human human ADJ fnp-6284 40 4 fetal fetal ADJ fnp-6284 40 5 brains brain NOUN fnp-6284 40 6 from from ADP fnp-6284 40 7 9–41 9–41 PROPN fnp-6284 40 8 weeks week NOUN fnp-6284 40 9 gestational gestational ADJ fnp-6284 40 10 age age NOUN fnp-6284 40 11 were be AUX fnp-6284 40 12 studied study VERB fnp-6284 40 13 at at ADP fnp-6284 40 14 autopsy autopsy ADJ fnp-6284 40 15 . . PUNCT fnp-6284 41 1 ks ks PROPN fnp-6284 41 2 was be AUX fnp-6284 41 3 examined examine VERB fnp-6284 41 4 by by ADP fnp-6284 41 5 immunoreactivity immunoreactivity NOUN fnp-6284 41 6 in in ADP fnp-6284 41 7 formalin formalin NOUN fnp-6284 41 8 - - PUNCT fnp-6284 41 9 fixed fix VERB fnp-6284 41 10 paraffin paraffin NOUN fnp-6284 41 11 sections section NOUN fnp-6284 41 12 , , PUNCT fnp-6284 41 13 plus plus CCONJ fnp-6284 41 14 other other ADJ fnp-6284 41 15 markers marker NOUN fnp-6284 41 16 including include VERB fnp-6284 41 17 synaptophysin synaptophysin NOUN fnp-6284 41 18 , , PUNCT fnp-6284 41 19 s-100β s-100β ADJ fnp-6284 41 20 protein protein NOUN fnp-6284 41 21 , , PUNCT fnp-6284 41 22 vimentin vimentin NOUN fnp-6284 41 23 and and CCONJ fnp-6284 41 24 nestin nestin NOUN fnp-6284 41 25 . . PUNCT fnp-6284 42 1 results result NOUN fnp-6284 42 2 . . PUNCT fnp-6284 43 1 radial radial ADJ fnp-6284 43 2 and and CCONJ fnp-6284 43 3 tangential tangential ADJ fnp-6284 43 4 neuroblast neuroblast NOUN fnp-6284 43 5 migratory migratory NOUN fnp-6284 43 6 pathways pathway NOUN fnp-6284 43 7 from from ADP fnp-6284 43 8 subventricular subventricular PROPN fnp-6284 43 9 zone zone NOUN fnp-6284 43 10 to to ADP fnp-6284 43 11 cortical cortical ADJ fnp-6284 43 12 plate plate NOUN fnp-6284 43 13 were be AUX fnp-6284 43 14 marked mark VERB fnp-6284 43 15 by by ADP fnp-6284 43 16 ks k NOUN fnp-6284 43 17 deposits deposit NOUN fnp-6284 43 18 as as ADV fnp-6284 43 19 early early ADV fnp-6284 43 20 as as ADP fnp-6284 43 21 9wk 9wk PROPN fnp-6284 43 22 ga ga PROPN fnp-6284 43 23 , , PUNCT fnp-6284 43 24 shortly shortly ADV fnp-6284 43 25 after after SCONJ fnp-6284 43 26 neuroblast neuroblast NOUN fnp-6284 43 27 migration migration NOUN fnp-6284 43 28 initiated initiate VERB fnp-6284 43 29 . . PUNCT fnp-6284 44 1 during during ADP fnp-6284 44 2 later later ADJ fnp-6284 44 3 gestation gestation NOUN fnp-6284 44 4 this this DET fnp-6284 44 5 reactivity reactivity NOUN fnp-6284 44 6 gradually gradually ADV fnp-6284 44 7 diminished diminish VERB fnp-6284 44 8 and and CCONJ fnp-6284 44 9 disappeared disappear VERB fnp-6284 44 10 by by ADP fnp-6284 44 11 term term NOUN fnp-6284 44 12 . . PUNCT fnp-6284 45 1 long long ADJ fnp-6284 45 2 axonal axonal ADJ fnp-6284 45 3 fascicles fascicle NOUN fnp-6284 45 4 of of ADP fnp-6284 45 5 the the DET fnp-6284 45 6 internal internal ADJ fnp-6284 45 7 capsule capsule NOUN fnp-6284 45 8 and and CCONJ fnp-6284 45 9 short short ADJ fnp-6284 45 10 fascicles fascicle NOUN fnp-6284 45 11 of of ADP fnp-6284 45 12 intrinsic intrinsic ADJ fnp-6284 45 13 bundles bundle NOUN fnp-6284 45 14 of of ADP fnp-6284 45 15 globus globus NOUN fnp-6284 45 16 pallidus pallidus NOUN fnp-6284 45 17 and and CCONJ fnp-6284 45 18 corpus corpus NOUN fnp-6284 45 19 striatum striatum NOUN fnp-6284 45 20 also also ADV fnp-6284 45 21 appeared appear VERB fnp-6284 45 22 as as ADV fnp-6284 45 23 early early ADV fnp-6284 45 24 as as ADP fnp-6284 45 25 9–12wk 9–12wk NOUN fnp-6284 45 26 , , PUNCT fnp-6284 45 27 as as SCONJ fnp-6284 45 28 fascicular fascicular ADJ fnp-6284 45 29 sleeves sleeve NOUN fnp-6284 45 30 before before ADP fnp-6284 45 31 axons axon NOUN fnp-6284 45 32 even even ADV fnp-6284 45 33 entered enter VERB fnp-6284 45 34 . . PUNCT fnp-6284 46 1 intense intense ADJ fnp-6284 46 2 ks ks NOUN fnp-6284 46 3 occurs occur VERB fnp-6284 46 4 in in ADP fnp-6284 46 5 astrocytic astrocytic ADJ fnp-6284 46 6 cytoplasm cytoplasm NOUN fnp-6284 46 7 and and CCONJ fnp-6284 46 8 extracellular extracellular ADJ fnp-6284 46 9 parenchyma parenchyma NOUN fnp-6284 46 10 at at ADP fnp-6284 46 11 9wk 9wk NOUN fnp-6284 46 12 in in ADP fnp-6284 46 13 globus globus ADJ fnp-6284 46 14 pallidus pallidus NOUN fnp-6284 46 15 , , PUNCT fnp-6284 46 16 15wk 15wk PROPN fnp-6284 46 17 thalamus thalamus PROPN fnp-6284 46 18 , , PUNCT fnp-6284 46 19 18wk 18wk ADJ fnp-6284 46 20 corpus corpus NOUN fnp-6284 46 21 striatum striatum NOUN fnp-6284 46 22 , , PUNCT fnp-6284 46 23 22wk 22wk ADJ fnp-6284 46 24 cortical cortical ADJ fnp-6284 46 25 plate plate NOUN fnp-6284 46 26 , , PUNCT fnp-6284 46 27 and and CCONJ fnp-6284 46 28 hippocampus hippocampus VERB fnp-6284 46 29 postnatally postnatally ADV fnp-6284 46 30 . . PUNCT fnp-6284 47 1 corpus corpus NOUN fnp-6284 47 2 callosum callosum PROPN fnp-6284 47 3 and and CCONJ fnp-6284 47 4 anterior anterior ADJ fnp-6284 47 5 commissure commissure NOUN fnp-6284 47 6 do do AUX fnp-6284 47 7 not not PART fnp-6284 47 8 exhibit exhibit VERB fnp-6284 47 9 ks ks NOUN fnp-6284 47 10 at at ADP fnp-6284 47 11 any any DET fnp-6284 47 12 age age NOUN fnp-6284 47 13 . . PUNCT fnp-6284 48 1 optic optic ADJ fnp-6284 48 2 chiasm chiasm NOUN fnp-6284 48 3 shows show VERB fnp-6284 48 4 peripheral peripheral ADJ fnp-6284 48 5 reactivity reactivity NOUN fnp-6284 48 6 but but CCONJ fnp-6284 48 7 not not PART fnp-6284 48 8 around around ADP fnp-6284 48 9 intrinsic intrinsic ADJ fnp-6284 48 10 subfasciculi subfasciculi NOUN fnp-6284 48 11 . . PUNCT fnp-6284 49 1 cross cross ADJ fnp-6284 49 2 - - NOUN fnp-6284 49 3 immunoreactivity immunoreactivity NOUN fnp-6284 49 4 with with ADP fnp-6284 49 5 aggrecan aggrecan PROPN fnp-6284 49 6 may may AUX fnp-6284 49 7 confuse confuse VERB fnp-6284 49 8 molecular molecular ADJ fnp-6284 49 9 distinctions distinction NOUN fnp-6284 49 10 . . PUNCT fnp-6284 50 1 conclusion conclusion NOUN fnp-6284 50 2 . . PUNCT fnp-6284 51 1 ks k NOUN fnp-6284 51 2 forms form VERB fnp-6284 51 3 a a DET fnp-6284 51 4 putative putative ADJ fnp-6284 51 5 chemical chemical NOUN fnp-6284 51 6 template template NOUN fnp-6284 51 7 ( ( PUNCT fnp-6284 51 8 but but CCONJ fnp-6284 51 9 not not PART fnp-6284 51 10 a a DET fnp-6284 51 11 structural structural ADJ fnp-6284 51 12 scaffold scaffold NOUN fnp-6284 51 13 ) ) PUNCT fnp-6284 51 14 for for ADP fnp-6284 51 15 many many ADJ fnp-6284 51 16 long long ADJ fnp-6284 51 17 and and CCONJ fnp-6284 51 18 short short ADJ fnp-6284 51 19 axonal axonal ADJ fnp-6284 51 20 fascicles fascicle NOUN fnp-6284 51 21 before before SCONJ fnp-6284 51 22 axons axon NOUN fnp-6284 51 23 enter enter VERB fnp-6284 51 24 and and CCONJ fnp-6284 51 25 for for ADP fnp-6284 51 26 neuroblast neuroblast NOUN fnp-6284 51 27 migratory migratory NOUN fnp-6284 51 28 pathways pathway NOUN fnp-6284 51 29 at at ADP fnp-6284 51 30 initiation initiation NOUN fnp-6284 51 31 of of ADP fnp-6284 51 32 migration migration NOUN fnp-6284 51 33 . . PUNCT fnp-6284 51 34     SPACE fnp-6284 52 1 abstract abstract ADJ fnp-6284 52 2 4 4 NUM fnp-6284 52 3 free free ADJ fnp-6284 52 4 neuropathol neuropathol NOUN fnp-6284 52 5 6:1:7 6:1:7 NUM fnp-6284 52 6 unique unique ADJ fnp-6284 52 7 neuropathological neuropathological ADJ fnp-6284 52 8 mechanisms mechanism NOUN fnp-6284 52 9 underlying underlie VERB fnp-6284 52 10 cognitive cognitive ADJ fnp-6284 52 11 impairment impairment NOUN fnp-6284 52 12 in in ADP fnp-6284 52 13 schizophrenia schizophrenia PROPN fnp-6284 52 14 naomi naomi PROPN fnp-6284 52 15 c. c. PROPN fnp-6284 52 16 futhey1 futhey1 PROPN fnp-6284 52 17 , , PUNCT fnp-6284 52 18 elizabeth elizabeth PROPN fnp-6284 52 19 gregory1,3 gregory1,3 PROPN fnp-6284 52 20 , , PUNCT fnp-6284 52 21 belen belen PROPN fnp-6284 52 22 arranz4 arranz4 PROPN fnp-6284 52 23 , , PUNCT fnp-6284 52 24 josep josep PROPN fnp-6284 52 25 maria maria PROPN fnp-6284 52 26 haro4 haro4 PROPN fnp-6284 52 27 , , PUNCT fnp-6284 52 28 fidel fidel PROPN fnp-6284 52 29 vila vila PROPN fnp-6284 52 30 - - PUNCT fnp-6284 52 31 rodriguez3,5 rodriguez3,5 PROPN fnp-6284 52 32 , , PUNCT fnp-6284 52 33 mark mark PROPN fnp-6284 52 34 s. s. PROPN fnp-6284 52 35 cembrowski2,5–7 cembrowski2,5–7 PROPN fnp-6284 52 36 , , PUNCT fnp-6284 52 37 veronica veronica PROPN fnp-6284 52 38 hirsch hirsch PROPN fnp-6284 52 39 - - PUNCT fnp-6284 52 40 reinshagen8 reinshagen8 PROPN fnp-6284 52 41 md md PROPN fnp-6284 52 42 / / SYM fnp-6284 52 43 phd phd NOUN fnp-6284 52 44 program program NOUN fnp-6284 52 45 , , PUNCT fnp-6284 52 46 university university NOUN fnp-6284 52 47 of of ADP fnp-6284 52 48 british british PROPN fnp-6284 52 49 columbia columbia PROPN fnp-6284 52 50 , , PUNCT fnp-6284 52 51 vancouver vancouver PROPN fnp-6284 52 52 , , PUNCT fnp-6284 52 53 canada canada PROPN fnp-6284 52 54 department department PROPN fnp-6284 52 55 of of ADP fnp-6284 52 56 cellular cellular ADJ fnp-6284 52 57 and and CCONJ fnp-6284 52 58 physiological physiological ADJ fnp-6284 52 59 sciences science NOUN fnp-6284 52 60 , , PUNCT fnp-6284 52 61 life life NOUN fnp-6284 52 62 sciences sciences PROPN fnp-6284 52 63 institute institute PROPN fnp-6284 52 64 , , PUNCT fnp-6284 52 65 university university PROPN fnp-6284 52 66 of of ADP fnp-6284 52 67 british british PROPN fnp-6284 52 68 columbia columbia PROPN fnp-6284 52 69 , , PUNCT fnp-6284 52 70 vancouver vancouver PROPN fnp-6284 52 71 , , PUNCT fnp-6284 52 72 canada canada PROPN fnp-6284 52 73 non non ADJ fnp-6284 52 74 - - ADJ fnp-6284 52 75 invasive invasive ADJ fnp-6284 52 76 neurostimulation neurostimulation NOUN fnp-6284 52 77 therapies therapie VERB fnp-6284 52 78 laboratory laboratory NOUN fnp-6284 52 79 , , PUNCT fnp-6284 52 80 department department NOUN fnp-6284 52 81 of of ADP fnp-6284 52 82 psychiatry psychiatry NOUN fnp-6284 52 83 , , PUNCT fnp-6284 52 84 university university NOUN fnp-6284 52 85 of of ADP fnp-6284 52 86 british british PROPN fnp-6284 52 87 columbia columbia PROPN fnp-6284 52 88 , , PUNCT fnp-6284 52 89 vancouver vancouver PROPN fnp-6284 52 90 , , PUNCT fnp-6284 52 91 canada canada PROPN fnp-6284 52 92 sant sant PROPN fnp-6284 52 93 joan joan PROPN fnp-6284 52 94 de de PROPN fnp-6284 52 95 déu déu PROPN fnp-6284 52 96 , , PUNCT fnp-6284 52 97 serveis serveis PROPN fnp-6284 52 98 de de PROPN fnp-6284 52 99 salut salut X fnp-6284 52 100 mental mental PROPN fnp-6284 52 101 , , PUNCT fnp-6284 52 102 barcelona barcelona PROPN fnp-6284 52 103 , , PUNCT fnp-6284 52 104 spain spain PROPN fnp-6284 52 105 school school PROPN fnp-6284 52 106 of of ADP fnp-6284 52 107 biomedical biomedical ADJ fnp-6284 52 108 engineering engineering NOUN fnp-6284 52 109 , , PUNCT fnp-6284 52 110 university university NOUN fnp-6284 52 111 of of ADP fnp-6284 52 112 british british PROPN fnp-6284 52 113 columbia columbia PROPN fnp-6284 52 114 , , PUNCT fnp-6284 52 115 vancouver vancouver PROPN fnp-6284 52 116 , , PUNCT fnp-6284 52 117 canada canada PROPN fnp-6284 52 118 djavad djavad PROPN fnp-6284 52 119 mowafaghian mowafaghian PROPN fnp-6284 52 120 centre centre PROPN fnp-6284 52 121 for for ADP fnp-6284 52 122 brain brain NOUN fnp-6284 52 123 health health NOUN fnp-6284 52 124 , , PUNCT fnp-6284 52 125 university university NOUN fnp-6284 52 126 of of ADP fnp-6284 52 127 british british PROPN fnp-6284 52 128 columbia columbia PROPN fnp-6284 52 129 , , PUNCT fnp-6284 52 130 vancouver vancouver PROPN fnp-6284 52 131 , , PUNCT fnp-6284 52 132 canada canada PROPN fnp-6284 52 133 department department PROPN fnp-6284 52 134 of of ADP fnp-6284 52 135 mathematics mathematics PROPN fnp-6284 52 136 , , PUNCT fnp-6284 52 137 university university PROPN fnp-6284 52 138 of of ADP fnp-6284 52 139 british british PROPN fnp-6284 52 140 columbia columbia PROPN fnp-6284 52 141 , , PUNCT fnp-6284 52 142 vancouver vancouver PROPN fnp-6284 52 143 , , PUNCT fnp-6284 52 144 canada canada PROPN fnp-6284 52 145 department department PROPN fnp-6284 52 146 of of ADP fnp-6284 52 147 pathology pathology PROPN fnp-6284 52 148 and and CCONJ fnp-6284 52 149 laboratory laboratory NOUN fnp-6284 52 150 medicine medicine NOUN fnp-6284 52 151 , , PUNCT fnp-6284 52 152 university university NOUN fnp-6284 52 153 of of ADP fnp-6284 52 154 british british PROPN fnp-6284 52 155 columbia columbia PROPN fnp-6284 52 156 , , PUNCT fnp-6284 52 157 vancouver vancouver PROPN fnp-6284 52 158 , , PUNCT fnp-6284 52 159 canada canada PROPN fnp-6284 52 160 cognitive cognitive ADJ fnp-6284 52 161 impairment impairment NOUN fnp-6284 52 162 is be AUX fnp-6284 52 163 a a DET fnp-6284 52 164 core core ADJ fnp-6284 52 165 tenet tenet NOUN fnp-6284 52 166 of of ADP fnp-6284 52 167 chronic chronic ADJ fnp-6284 52 168 schizophrenia schizophrenia NOUN fnp-6284 52 169 , , PUNCT fnp-6284 52 170 impacting impact VERB fnp-6284 52 171 as as ADV fnp-6284 52 172 many many ADJ fnp-6284 52 173 as as ADP fnp-6284 52 174 98 98 NUM fnp-6284 52 175     SPACE fnp-6284 52 176 % % NOUN fnp-6284 52 177 of of ADP fnp-6284 52 178 patients patient NOUN fnp-6284 52 179 . . PUNCT fnp-6284 53 1 it it PRON fnp-6284 53 2 is be AUX fnp-6284 53 3 not not PART fnp-6284 53 4 targeted target VERB fnp-6284 53 5 by by ADP fnp-6284 53 6 any any DET fnp-6284 53 7 currently currently ADV fnp-6284 53 8 available available ADJ fnp-6284 53 9 therapies therapy NOUN fnp-6284 53 10 , , PUNCT fnp-6284 53 11 and and CCONJ fnp-6284 53 12 the the DET fnp-6284 53 13 underlying underlying ADJ fnp-6284 53 14 neuropathology neuropathology NOUN fnp-6284 53 15 only only ADV fnp-6284 53 16 occasionally occasionally ADV fnp-6284 53 17 includes include VERB fnp-6284 53 18 neurodegenerative neurodegenerative ADJ fnp-6284 53 19 processes process NOUN fnp-6284 53 20 such such ADJ fnp-6284 53 21 as as ADP fnp-6284 53 22 alzheimer alzheimer PROPN fnp-6284 53 23 ’s ’s PART fnp-6284 53 24 disease disease NOUN fnp-6284 53 25 . . PUNCT fnp-6284 54 1 this this DET fnp-6284 54 2 study study NOUN fnp-6284 54 3 seeks seek VERB fnp-6284 54 4 to to PART fnp-6284 54 5 understand understand VERB fnp-6284 54 6 the the DET fnp-6284 54 7 cellular cellular ADJ fnp-6284 54 8 mechanisms mechanism NOUN fnp-6284 54 9 for for ADP fnp-6284 54 10 cognitive cognitive ADJ fnp-6284 54 11 impairment impairment NOUN fnp-6284 54 12 which which PRON fnp-6284 54 13 may may AUX fnp-6284 54 14 be be AUX fnp-6284 54 15 unique unique ADJ fnp-6284 54 16 to to ADP fnp-6284 54 17 schizophrenia schizophrenia NOUN fnp-6284 54 18 . . PUNCT fnp-6284 55 1 demographic demographic ADJ fnp-6284 55 2 , , PUNCT fnp-6284 55 3 clinical clinical ADJ fnp-6284 55 4 , , PUNCT fnp-6284 55 5 and and CCONJ fnp-6284 55 6 autopsy autopsy ADJ fnp-6284 55 7 data datum NOUN fnp-6284 55 8 were be AUX fnp-6284 55 9 obtained obtain VERB fnp-6284 55 10 for for ADP fnp-6284 55 11 55 55 NUM fnp-6284 55 12 elderly elderly ADJ fnp-6284 55 13 patients patient NOUN fnp-6284 55 14 with with ADP fnp-6284 55 15 chronic chronic ADJ fnp-6284 55 16 schizophrenia schizophrenia NOUN fnp-6284 55 17 and and CCONJ fnp-6284 55 18 post post ADJ fnp-6284 55 19 - - ADJ fnp-6284 55 20 mortem mortem ADJ fnp-6284 55 21 neuropathological neuropathological ADJ fnp-6284 55 22 evaluation evaluation NOUN fnp-6284 55 23 , , PUNCT fnp-6284 55 24 with with ADP fnp-6284 55 25 additional additional ADJ fnp-6284 55 26 neuropsychological neuropsychological ADJ fnp-6284 55 27 testing testing NOUN fnp-6284 55 28 conducted conduct VERB fnp-6284 55 29 during during ADP fnp-6284 55 30 life life NOUN fnp-6284 55 31 in in ADP fnp-6284 55 32 a a DET fnp-6284 55 33 subset subset NOUN fnp-6284 55 34 . . PUNCT fnp-6284 56 1 standard standard ADJ fnp-6284 56 2 evaluation evaluation NOUN fnp-6284 56 3 of of ADP fnp-6284 56 4 neurodegenerative neurodegenerative ADJ fnp-6284 56 5 conditions condition NOUN fnp-6284 56 6 and and CCONJ fnp-6284 56 7 exploratory exploratory ADJ fnp-6284 56 8 data datum NOUN fnp-6284 56 9 analyses analysis NOUN fnp-6284 56 10 including include VERB fnp-6284 56 11 clinical clinical ADJ fnp-6284 56 12 - - PUNCT fnp-6284 56 13 pathological pathological ADJ fnp-6284 56 14 correlations correlation NOUN fnp-6284 56 15 were be AUX fnp-6284 56 16 performed perform VERB fnp-6284 56 17 . . PUNCT fnp-6284 57 1 further further ADJ fnp-6284 57 2 dimensionality dimensionality NOUN fnp-6284 57 3 reduction reduction NOUN fnp-6284 57 4 and and CCONJ fnp-6284 57 5 clustering cluster VERB fnp-6284 57 6 analysis analysis NOUN fnp-6284 57 7 were be AUX fnp-6284 57 8 conducted conduct VERB fnp-6284 57 9 using use VERB fnp-6284 57 10 uniform uniform ADJ fnp-6284 57 11 manifold manifold ADJ fnp-6284 57 12 approximation approximation NOUN fnp-6284 57 13 and and CCONJ fnp-6284 57 14 projection projection NOUN fnp-6284 57 15 ( ( PUNCT fnp-6284 57 16 umap umap ADJ fnp-6284 57 17 ) ) PUNCT fnp-6284 57 18 and and CCONJ fnp-6284 57 19 k k X fnp-6284 57 20 - - PUNCT fnp-6284 57 21 means means NOUN fnp-6284 57 22 clustering cluster VERB fnp-6284 57 23 to to PART fnp-6284 57 24 illustrate illustrate VERB fnp-6284 57 25 characteristics characteristic NOUN fnp-6284 57 26 of of ADP fnp-6284 57 27 patient patient ADJ fnp-6284 57 28 subpopulations subpopulation NOUN fnp-6284 57 29 . . PUNCT fnp-6284 58 1 on on ADP fnp-6284 58 2 average average ADJ fnp-6284 58 3 , , PUNCT fnp-6284 58 4 patients patient NOUN fnp-6284 58 5 experienced experience VERB fnp-6284 58 6 multiple multiple ADJ fnp-6284 58 7 decades decade NOUN fnp-6284 58 8 of of ADP fnp-6284 58 9 symptoms symptom NOUN fnp-6284 58 10 , , PUNCT fnp-6284 58 11 with with ADP fnp-6284 58 12 marked mark VERB fnp-6284 58 13 disruption disruption NOUN fnp-6284 58 14 of of ADP fnp-6284 58 15 reality reality NOUN fnp-6284 58 16 by by ADP fnp-6284 58 17 hallucinations hallucination NOUN fnp-6284 58 18 and and CCONJ fnp-6284 58 19 delusions delusion NOUN fnp-6284 58 20 . . PUNCT fnp-6284 59 1 scoring scoring NOUN fnp-6284 59 2 of of ADP fnp-6284 59 3 negative negative ADJ fnp-6284 59 4 symptoms symptom NOUN fnp-6284 59 5 at at ADP fnp-6284 59 6 this this DET fnp-6284 59 7 advanced advanced ADJ fnp-6284 59 8 disease disease NOUN fnp-6284 59 9 stage stage NOUN fnp-6284 59 10 outweighed outweigh VERB fnp-6284 59 11 that that PRON fnp-6284 59 12 of of ADP fnp-6284 59 13 positive positive ADJ fnp-6284 59 14 symptoms symptom NOUN fnp-6284 59 15 , , PUNCT fnp-6284 59 16 although although SCONJ fnp-6284 59 17 both both PRON fnp-6284 59 18 were be AUX fnp-6284 59 19 present present ADJ fnp-6284 59 20 . . PUNCT fnp-6284 60 1 significant significant ADJ fnp-6284 60 2 cognitive cognitive ADJ fnp-6284 60 3 impairment impairment NOUN fnp-6284 60 4 was be AUX fnp-6284 60 5 noted note VERB fnp-6284 60 6 across across ADP fnp-6284 60 7 different different ADJ fnp-6284 60 8 neuropsychological neuropsychological ADJ fnp-6284 60 9 testing testing NOUN fnp-6284 60 10 modalities modality NOUN fnp-6284 60 11 . . PUNCT fnp-6284 61 1 only only ADV fnp-6284 61 2 56 56 NUM fnp-6284 61 3     SPACE fnp-6284 61 4 % % NOUN fnp-6284 61 5 of of ADP fnp-6284 61 6 patients patient NOUN fnp-6284 61 7 had have VERB fnp-6284 61 8 sufficiently sufficiently ADV fnp-6284 61 9 severe severe ADJ fnp-6284 61 10 neuropathological neuropathological ADJ fnp-6284 61 11 changes change NOUN fnp-6284 61 12 to to PART fnp-6284 61 13 explain explain VERB fnp-6284 61 14 their their PRON fnp-6284 61 15 cognitive cognitive ADJ fnp-6284 61 16 impairment impairment NOUN fnp-6284 61 17 , , PUNCT fnp-6284 61 18 and and CCONJ fnp-6284 61 19 distinct distinct ADJ fnp-6284 61 20 subpopulations subpopulation NOUN fnp-6284 61 21 were be AUX fnp-6284 61 22 highlighted highlight VERB fnp-6284 61 23 in in ADP fnp-6284 61 24 clustering cluster VERB fnp-6284 61 25 analysis analysis NOUN fnp-6284 61 26 . . PUNCT fnp-6284 62 1 together together ADV fnp-6284 62 2 , , PUNCT fnp-6284 62 3 this this PRON fnp-6284 62 4 suggests suggest VERB fnp-6284 62 5 the the DET fnp-6284 62 6 presence presence NOUN fnp-6284 62 7 of of ADP fnp-6284 62 8 additional additional ADJ fnp-6284 62 9 mechanisms mechanism NOUN fnp-6284 62 10 underlying underlie VERB fnp-6284 62 11 cognitive cognitive ADJ fnp-6284 62 12 impairment impairment NOUN fnp-6284 62 13 in in ADP fnp-6284 62 14 chronic chronic ADJ fnp-6284 62 15 schizophrenia schizophrenia NOUN fnp-6284 62 16 . . PUNCT fnp-6284 63 1 better well ADJ fnp-6284 63 2 understanding understanding NOUN fnp-6284 63 3 of of ADP fnp-6284 63 4 the the DET fnp-6284 63 5 pathophysiology pathophysiology NOUN fnp-6284 63 6 of of ADP fnp-6284 63 7 this this DET fnp-6284 63 8 impairment impairment NOUN fnp-6284 63 9 may may AUX fnp-6284 63 10 inform inform VERB fnp-6284 63 11 our our PRON fnp-6284 63 12 knowledge knowledge NOUN fnp-6284 63 13 of of ADP fnp-6284 63 14 schizophrenia schizophrenia NOUN fnp-6284 63 15 as as ADP fnp-6284 63 16 a a DET fnp-6284 63 17 whole whole NOUN fnp-6284 63 18 and and CCONJ fnp-6284 63 19 provide provide VERB fnp-6284 63 20 the the DET fnp-6284 63 21 basis basis NOUN fnp-6284 63 22 for for ADP fnp-6284 63 23 novel novel ADJ fnp-6284 63 24 precision precision NOUN fnp-6284 63 25 medicine medicine NOUN fnp-6284 63 26 applications application NOUN fnp-6284 63 27 . . PUNCT fnp-6284 63 28     SPACE fnp-6284 64 1 abstract abstract ADJ fnp-6284 64 2 5 5 NUM fnp-6284 64 3 free free ADJ fnp-6284 64 4 neuropathol neuropathol NOUN fnp-6284 64 5 6:1:8 6:1:8 NUM fnp-6284 64 6 recent recent ADJ fnp-6284 64 7 advances advance NOUN fnp-6284 64 8 in in ADP fnp-6284 64 9 spatial spatial ADJ fnp-6284 64 10 transcriptomics transcriptomic NOUN fnp-6284 64 11 of of ADP fnp-6284 64 12 the the DET fnp-6284 64 13 extracellular extracellular ADJ fnp-6284 64 14 matrix matrix NOUN fnp-6284 64 15 erin erin PROPN fnp-6284 64 16 l. l. PROPN fnp-6284 64 17 stephenson1 stephenson1 PROPN fnp-6284 64 18 , , PUNCT fnp-6284 64 19 rajiv rajiv PROPN fnp-6284 64 20 w. w. PROPN fnp-6284 64 21 jain2 jain2 PROPN fnp-6284 64 22 , , PUNCT fnp-6284 64 23 samira samira PROPN fnp-6284 64 24 ghorbani2 ghorbani2 PROPN fnp-6284 64 25 , , PUNCT fnp-6284 64 26 rianne rianne PROPN fnp-6284 64 27 p. p. PROPN fnp-6284 64 28 gorter2 gorter2 PROPN fnp-6284 64 29 , , PUNCT fnp-6284 64 30 charlotte charlotte PROPN fnp-6284 64 31 d’mello2 d’mello2 PROPN fnp-6284 64 32 , , PUNCT fnp-6284 64 33 voon voon PROPN fnp-6284 64 34 wee wee ADJ fnp-6284 64 35 yong2 yong2 PROPN fnp-6284 64 36 department department PROPN fnp-6284 64 37 of of ADP fnp-6284 64 38 pathology pathology PROPN fnp-6284 64 39 and and CCONJ fnp-6284 64 40 laboratory laboratory NOUN fnp-6284 64 41 medicine medicine NOUN fnp-6284 64 42 , , PUNCT fnp-6284 64 43 university university NOUN fnp-6284 64 44 of of ADP fnp-6284 64 45 calgary calgary PROPN fnp-6284 64 46 , , PUNCT fnp-6284 64 47 calgary calgary PROPN fnp-6284 64 48 , , PUNCT fnp-6284 64 49 ab ab PROPN fnp-6284 64 50 , , PUNCT fnp-6284 64 51 canada canada PROPN fnp-6284 64 52 hotchkiss hotchkiss PROPN fnp-6284 64 53 brain brain PROPN fnp-6284 64 54 institute institute PROPN fnp-6284 64 55 and and CCONJ fnp-6284 64 56 department department PROPN fnp-6284 64 57 of of ADP fnp-6284 64 58 clinical clinical ADJ fnp-6284 64 59 neurosciences neuroscience NOUN fnp-6284 64 60 , , PUNCT fnp-6284 64 61 university university NOUN fnp-6284 64 62 of of ADP fnp-6284 64 63 calgary calgary PROPN fnp-6284 64 64 , , PUNCT fnp-6284 64 65 ab ab PROPN fnp-6284 64 66 , , PUNCT fnp-6284 64 67 canada canada PROPN fnp-6284 64 68 the the DET fnp-6284 64 69 extracellular extracellular ADJ fnp-6284 64 70 matrix matrix NOUN fnp-6284 64 71 ( ( PUNCT fnp-6284 64 72 ecm ecm NOUN fnp-6284 64 73 ) ) PUNCT fnp-6284 64 74 of of ADP fnp-6284 64 75 the the DET fnp-6284 64 76 central central ADJ fnp-6284 64 77 nervous nervous ADJ fnp-6284 64 78 system system NOUN fnp-6284 64 79 ( ( PUNCT fnp-6284 64 80 cns cns NOUN fnp-6284 64 81 ) ) PUNCT fnp-6284 64 82 is be AUX fnp-6284 64 83 an an DET fnp-6284 64 84 interconnected interconnected ADJ fnp-6284 64 85 network network NOUN fnp-6284 64 86 of of ADP fnp-6284 64 87 proteins protein NOUN fnp-6284 64 88 and and CCONJ fnp-6284 64 89 polysaccharides polysaccharide NOUN fnp-6284 64 90 with with ADP fnp-6284 64 91 critical critical ADJ fnp-6284 64 92 roles role NOUN fnp-6284 64 93 in in ADP fnp-6284 64 94 maintaining maintain VERB fnp-6284 64 95 brain brain NOUN fnp-6284 64 96 homeostasis homeostasis NOUN fnp-6284 64 97 and and CCONJ fnp-6284 64 98 modulating modulate VERB fnp-6284 64 99 responses response NOUN fnp-6284 64 100 to to ADP fnp-6284 64 101 injury injury NOUN fnp-6284 64 102 . . PUNCT fnp-6284 65 1 in in ADP fnp-6284 65 2 neurological neurological ADJ fnp-6284 65 3 diseases disease NOUN fnp-6284 65 4 , , PUNCT fnp-6284 65 5 alterations alteration NOUN fnp-6284 65 6 of of ADP fnp-6284 65 7 the the DET fnp-6284 65 8 ecm ecm NOUN fnp-6284 65 9 can can AUX fnp-6284 65 10 be be AUX fnp-6284 65 11 beneficial beneficial ADJ fnp-6284 65 12 or or CCONJ fnp-6284 65 13 detrimental detrimental ADJ fnp-6284 65 14 depending depend VERB fnp-6284 65 15 on on ADP fnp-6284 65 16 the the DET fnp-6284 65 17 constellation constellation NOUN fnp-6284 65 18 of of ADP fnp-6284 65 19 changes change NOUN fnp-6284 65 20 . . PUNCT fnp-6284 66 1 however however ADV fnp-6284 66 2 , , PUNCT fnp-6284 66 3 there there PRON fnp-6284 66 4 is be VERB fnp-6284 66 5 a a DET fnp-6284 66 6 lack lack NOUN fnp-6284 66 7 of of ADP fnp-6284 66 8 data datum NOUN fnp-6284 66 9 investigating investigate VERB fnp-6284 66 10 how how SCONJ fnp-6284 66 11 ecm ecm NOUN fnp-6284 66 12 members member NOUN fnp-6284 66 13 change change VERB fnp-6284 66 14 in in ADP fnp-6284 66 15 relation relation NOUN fnp-6284 66 16 to to ADP fnp-6284 66 17 each each DET fnp-6284 66 18 other other ADJ fnp-6284 66 19 or or CCONJ fnp-6284 66 20 the the DET fnp-6284 66 21 relevance relevance NOUN fnp-6284 66 22 of of ADP fnp-6284 66 23 location location NOUN fnp-6284 66 24 following follow VERB fnp-6284 66 25 injury injury NOUN fnp-6284 66 26 . . PUNCT fnp-6284 67 1 the the DET fnp-6284 67 2 purpose purpose NOUN fnp-6284 67 3 of of ADP fnp-6284 67 4 this this DET fnp-6284 67 5 research research NOUN fnp-6284 67 6 was be AUX fnp-6284 67 7 to to PART fnp-6284 67 8 investigate investigate VERB fnp-6284 67 9 how how SCONJ fnp-6284 67 10 the the DET fnp-6284 67 11 ecm ecm NOUN fnp-6284 67 12 is be AUX fnp-6284 67 13 altered alter VERB fnp-6284 67 14 in in ADP fnp-6284 67 15 multiple multiple ADJ fnp-6284 67 16 sclerosis sclerosis NOUN fnp-6284 67 17 and and CCONJ fnp-6284 67 18 glioblastoma glioblastoma NOUN fnp-6284 67 19 , , PUNCT fnp-6284 67 20 and and CCONJ fnp-6284 67 21 the the DET fnp-6284 67 22 spatial spatial ADJ fnp-6284 67 23 heterogeneity heterogeneity NOUN fnp-6284 67 24 of of ADP fnp-6284 67 25 ecm ecm PROPN fnp-6284 67 26 changes change NOUN fnp-6284 67 27 . . PUNCT fnp-6284 68 1 active active ADJ fnp-6284 68 2 and and CCONJ fnp-6284 68 3 inactive inactive ADJ fnp-6284 68 4 demyelinated demyelinated ADJ fnp-6284 68 5 lesions lesion NOUN fnp-6284 68 6 from from ADP fnp-6284 68 7 multiple multiple ADJ fnp-6284 68 8 sclerosis sclerosis NOUN fnp-6284 68 9 were be AUX fnp-6284 68 10 investigated investigate VERB fnp-6284 68 11 with with ADP fnp-6284 68 12 a a DET fnp-6284 68 13 combination combination NOUN fnp-6284 68 14 of of ADP fnp-6284 68 15 spatial spatial ADJ fnp-6284 68 16 mrna mrna NOUN fnp-6284 68 17 - - PUNCT fnp-6284 68 18 sequencing sequencing ADJ fnp-6284 68 19 , , PUNCT fnp-6284 68 20 single single ADJ fnp-6284 68 21 - - PUNCT fnp-6284 68 22 nucleus nucleus NOUN fnp-6284 68 23 rna rna NOUN fnp-6284 68 24 sequencing sequencing NOUN fnp-6284 68 25 , , PUNCT fnp-6284 68 26 and and CCONJ fnp-6284 68 27 immunohistochemistry immunohistochemistry NOUN fnp-6284 68 28 . . PUNCT fnp-6284 69 1 there there PRON fnp-6284 69 2 were be VERB fnp-6284 69 3 widespread widespread ADJ fnp-6284 69 4 changes change NOUN fnp-6284 69 5 in in ADP fnp-6284 69 6 the the DET fnp-6284 69 7 ecm ecm NOUN fnp-6284 69 8 and and CCONJ fnp-6284 69 9 distinct distinct ADJ fnp-6284 69 10 ecm ecm NOUN fnp-6284 69 11 profiles profile NOUN fnp-6284 69 12 within within ADP fnp-6284 69 13 inactive inactive ADJ fnp-6284 69 14 cores core NOUN fnp-6284 69 15 , , PUNCT fnp-6284 69 16 lesion lesion NOUN fnp-6284 69 17 rims rim NOUN fnp-6284 69 18 , , PUNCT fnp-6284 69 19 and and CCONJ fnp-6284 69 20 surrounding surround VERB fnp-6284 69 21 white white ADJ fnp-6284 69 22 matter matter NOUN fnp-6284 69 23 ( ( PUNCT fnp-6284 69 24 int int NOUN fnp-6284 69 25 j j PROPN fnp-6284 69 26 mol mol ADP fnp-6284 69 27 sci sci PROPN fnp-6284 69 28 2024 2024 NUM fnp-6284 69 29 ; ; PUNCT fnp-6284 69 30 25(2):1240 25(2):1240 NUM fnp-6284 69 31 ) ) PUNCT fnp-6284 69 32 . . PUNCT fnp-6284 70 1 results result NOUN fnp-6284 70 2 uncovered uncover VERB fnp-6284 70 3 multiple multiple ADJ fnp-6284 70 4 novel novel ADJ fnp-6284 70 5 ecm ecm NOUN fnp-6284 70 6 targets target NOUN fnp-6284 70 7 , , PUNCT fnp-6284 70 8 including include VERB fnp-6284 70 9 the the DET fnp-6284 70 10 sparc sparc NOUN fnp-6284 70 11 family family NOUN fnp-6284 70 12 , , PUNCT fnp-6284 70 13 which which PRON fnp-6284 70 14 have have VERB fnp-6284 70 15 the the DET fnp-6284 70 16 capacity capacity NOUN fnp-6284 70 17 to to PART fnp-6284 70 18 affect affect VERB fnp-6284 70 19 immune immune ADJ fnp-6284 70 20 cell cell NOUN fnp-6284 70 21 activation activation NOUN fnp-6284 70 22 . . PUNCT fnp-6284 71 1 brain brain NOUN fnp-6284 71 2 parenchyma parenchyma NOUN fnp-6284 71 3 of of ADP fnp-6284 71 4 genetically genetically ADV fnp-6284 71 5 engineered engineer VERB fnp-6284 71 6 mice mouse NOUN fnp-6284 71 7 invaded invade VERB fnp-6284 71 8 by by ADP fnp-6284 71 9 glioblastoma glioblastoma NOUN fnp-6284 71 10 were be AUX fnp-6284 71 11 separated separate VERB fnp-6284 71 12 into into ADP fnp-6284 71 13 tumour tumour NOUN fnp-6284 71 14 core core NOUN fnp-6284 71 15 , , PUNCT fnp-6284 71 16 tumour tumour NOUN fnp-6284 71 17 edge edge NOUN fnp-6284 71 18 , , PUNCT fnp-6284 71 19 and and CCONJ fnp-6284 71 20 infiltrated infiltrate VERB fnp-6284 71 21 cortex cortex NOUN fnp-6284 71 22 and and CCONJ fnp-6284 71 23 analysed analyse VERB fnp-6284 71 24 using use VERB fnp-6284 71 25 spatial spatial ADJ fnp-6284 71 26 transcriptomics transcriptomic NOUN fnp-6284 71 27 . . PUNCT fnp-6284 72 1 there there PRON fnp-6284 72 2 were be AUX fnp-6284 72 3 differentially differentially ADV fnp-6284 72 4 expressed express VERB fnp-6284 72 5 ecm ecm NOUN fnp-6284 72 6 genes gene NOUN fnp-6284 72 7 that that PRON fnp-6284 72 8 defined define VERB fnp-6284 72 9 tumour tumour NOUN fnp-6284 72 10 regions region NOUN fnp-6284 72 11 and and CCONJ fnp-6284 72 12 unique unique ADJ fnp-6284 72 13 expression expression NOUN fnp-6284 72 14 was be AUX fnp-6284 72 15 associated associate VERB fnp-6284 72 16 with with ADP fnp-6284 72 17 different different ADJ fnp-6284 72 18 tumour tumour PRON fnp-6284 72 19 molecular molecular ADJ fnp-6284 72 20 drivers driver NOUN fnp-6284 72 21 . . PUNCT fnp-6284 73 1 the the DET fnp-6284 73 2 profound profound ADJ fnp-6284 73 3 spatial spatial ADJ fnp-6284 73 4 changes change NOUN fnp-6284 73 5 of of ADP fnp-6284 73 6 the the DET fnp-6284 73 7 ecm ecm NOUN fnp-6284 73 8 deserve deserve VERB fnp-6284 73 9 more more ADJ fnp-6284 73 10 scrutiny scrutiny NOUN fnp-6284 73 11 to to PART fnp-6284 73 12 appreciate appreciate VERB fnp-6284 73 13 the the DET fnp-6284 73 14 impact impact NOUN fnp-6284 73 15 on on ADP fnp-6284 73 16 neuroinflammation neuroinflammation NOUN fnp-6284 73 17 , , PUNCT fnp-6284 73 18 injury injury NOUN fnp-6284 73 19 , , PUNCT fnp-6284 73 20 and and CCONJ fnp-6284 73 21 repair repair NOUN fnp-6284 73 22 . . PUNCT fnp-6284 73 23     SPACE fnp-6284 74 1 abstract abstract ADJ fnp-6284 74 2 6 6 NUM fnp-6284 74 3 free free ADJ fnp-6284 74 4 neuropathol neuropathol NOUN fnp-6284 74 5 6:1:9 6:1:9 NUM fnp-6284 74 6 an an DET fnp-6284 74 7 anatomic anatomic ADJ fnp-6284 74 8 transcriptional transcriptional NOUN fnp-6284 74 9 atlas atla NOUN fnp-6284 74 10 of of ADP fnp-6284 74 11 focal focal ADJ fnp-6284 74 12 cortical cortical ADJ fnp-6284 74 13 dysplasia dysplasia NOUN fnp-6284 74 14 ameesha ameesha PROPN fnp-6284 74 15 paliwal1,2 paliwal1,2 PROPN fnp-6284 74 16 , , PUNCT fnp-6284 74 17 kevin kevin PROPN fnp-6284 74 18 faust2 faust2 PROPN fnp-6284 74 19 , , PUNCT fnp-6284 74 20 okty okty PROPN fnp-6284 74 21 a. a. NOUN fnp-6284 74 22 borhani2 borhani2 PROPN fnp-6284 74 23 , , PUNCT fnp-6284 74 24 parsa parsa PROPN fnp-6284 74 25 b. b. PROPN fnp-6284 74 26 zadeh2 zadeh2 PROPN fnp-6284 74 27 , , PUNCT fnp-6284 74 28 phedias phedias PROPN fnp-6284 74 29 diamandis1–4 diamandis1–4 PROPN fnp-6284 74 30 department department PROPN fnp-6284 74 31 of of ADP fnp-6284 74 32 laboratory laboratory NOUN fnp-6284 74 33 medicine medicine NOUN fnp-6284 74 34 and and CCONJ fnp-6284 74 35 pathobiology pathobiology NOUN fnp-6284 74 36 , , PUNCT fnp-6284 74 37 university university PROPN fnp-6284 74 38 of of ADP fnp-6284 74 39 toronto toronto PROPN fnp-6284 74 40 , , PUNCT fnp-6284 74 41 toronto toronto PROPN fnp-6284 74 42 , , PUNCT fnp-6284 74 43 on on ADP fnp-6284 74 44 m5s m5s NUM fnp-6284 74 45 1a8 1a8 NUM fnp-6284 74 46 , , PUNCT fnp-6284 74 47 canada canada PROPN fnp-6284 74 48 princess princess PROPN fnp-6284 74 49 margaret margaret PROPN fnp-6284 74 50 cancer cancer PROPN fnp-6284 74 51 centre centre PROPN fnp-6284 74 52 , , PUNCT fnp-6284 74 53 101 101 NUM fnp-6284 74 54 college college PROPN fnp-6284 74 55 street street PROPN fnp-6284 74 56 , , PUNCT fnp-6284 74 57 toronto toronto PROPN fnp-6284 74 58 , , PUNCT fnp-6284 74 59 on on ADP fnp-6284 74 60 m5 m5 PROPN fnp-6284 74 61 g g PROPN fnp-6284 74 62 1l7 1l7 NUM fnp-6284 74 63 , , PUNCT fnp-6284 74 64 canada canada PROPN fnp-6284 74 65 department department PROPN fnp-6284 74 66 of of ADP fnp-6284 74 67 medical medical ADJ fnp-6284 74 68 biophysics biophysic NOUN fnp-6284 74 69 , , PUNCT fnp-6284 74 70 university university PROPN fnp-6284 74 71 of of ADP fnp-6284 74 72 toronto toronto PROPN fnp-6284 74 73 , , PUNCT fnp-6284 74 74 101 101 NUM fnp-6284 74 75 college college PROPN fnp-6284 74 76 st st PROPN fnp-6284 74 77 , , PUNCT fnp-6284 74 78 toronto toronto PROPN fnp-6284 74 79 , , PUNCT fnp-6284 74 80 on on ADP fnp-6284 74 81 m5 m5 PROPN fnp-6284 74 82 g g PROPN fnp-6284 74 83 1l7 1l7 NUM fnp-6284 74 84 , , PUNCT fnp-6284 74 85 canada canada PROPN fnp-6284 74 86 laboratory laboratory PROPN fnp-6284 74 87 medicine medicine PROPN fnp-6284 74 88 program program PROPN fnp-6284 74 89 , , PUNCT fnp-6284 74 90 department department NOUN fnp-6284 74 91 of of ADP fnp-6284 74 92 pathology pathology PROPN fnp-6284 74 93 , , PUNCT fnp-6284 74 94 university university NOUN fnp-6284 74 95 health health NOUN fnp-6284 74 96 network network NOUN fnp-6284 74 97 , , PUNCT fnp-6284 74 98 200 200 NUM fnp-6284 74 99 elizabeth elizabeth PROPN fnp-6284 74 100 street street PROPN fnp-6284 74 101 , , PUNCT fnp-6284 74 102 toronto toronto PROPN fnp-6284 74 103 , , PUNCT fnp-6284 74 104 on on ADP fnp-6284 74 105 m5 m5 NOUN fnp-6284 74 106 g g PROPN fnp-6284 74 107 2c4 2c4 NUM fnp-6284 74 108 , , PUNCT fnp-6284 74 109 canada canada PROPN fnp-6284 74 110 focal focal ADJ fnp-6284 74 111 cortical cortical ADJ fnp-6284 74 112 dysplasia dysplasia NOUN fnp-6284 74 113 ( ( PUNCT fnp-6284 74 114 fcd fcd PROPN fnp-6284 74 115 ) ) PUNCT fnp-6284 74 116 is be AUX fnp-6284 74 117 a a DET fnp-6284 74 118 severe severe ADJ fnp-6284 74 119 neurodevelopmental neurodevelopmental ADJ fnp-6284 74 120 malformation malformation NOUN fnp-6284 74 121 that that PRON fnp-6284 74 122 manifests manifest VERB fnp-6284 74 123 in in ADP fnp-6284 74 124 medically medically ADV fnp-6284 74 125 refractory refractory NOUN fnp-6284 74 126 epilepsy epilepsy NOUN fnp-6284 74 127 . . PUNCT fnp-6284 75 1 fcd fcd PROPN fnp-6284 75 2 presents present VERB fnp-6284 75 3 with with ADP fnp-6284 75 4 classic classic ADJ fnp-6284 75 5 histological histological ADJ fnp-6284 75 6 hallmarks hallmark NOUN fnp-6284 75 7 , , PUNCT fnp-6284 75 8 such such ADJ fnp-6284 75 9 as as ADP fnp-6284 75 10 cytomegalic cytomegalic ADJ fnp-6284 75 11 dysmorphic dysmorphic ADJ fnp-6284 75 12 neurons neuron NOUN fnp-6284 75 13 , , PUNCT fnp-6284 75 14 that that PRON fnp-6284 75 15 are be AUX fnp-6284 75 16 presumed presume VERB fnp-6284 75 17 to to PART fnp-6284 75 18 be be AUX fnp-6284 75 19 key key ADJ fnp-6284 75 20 anatomical anatomical ADJ fnp-6284 75 21 drivers driver NOUN fnp-6284 75 22 of of ADP fnp-6284 75 23 disease disease NOUN fnp-6284 75 24 . . PUNCT fnp-6284 76 1 the the DET fnp-6284 76 2 relatively relatively ADV fnp-6284 76 3 low low ADJ fnp-6284 76 4 frequency frequency NOUN fnp-6284 76 5 and and CCONJ fnp-6284 76 6 interspersed interspersed ADJ fnp-6284 76 7 patterns pattern NOUN fnp-6284 76 8 of of ADP fnp-6284 76 9 dysmorphic dysmorphic ADJ fnp-6284 76 10 neurons neuron NOUN fnp-6284 76 11 within within ADP fnp-6284 76 12 resected resected ADJ fnp-6284 76 13 lesions lesion NOUN fnp-6284 76 14 has have AUX fnp-6284 76 15 challenged challenge VERB fnp-6284 76 16 traditional traditional ADJ fnp-6284 76 17 molecular molecular ADJ fnp-6284 76 18 characterization characterization NOUN fnp-6284 76 19 approaches approach NOUN fnp-6284 76 20 and and CCONJ fnp-6284 76 21 consequently consequently ADV fnp-6284 76 22 , , PUNCT fnp-6284 76 23 therapeutic therapeutic ADJ fnp-6284 76 24 options option NOUN fnp-6284 76 25 . . PUNCT fnp-6284 77 1 therefore therefore ADV fnp-6284 77 2 , , PUNCT fnp-6284 77 3 the the DET fnp-6284 77 4 objective objective NOUN fnp-6284 77 5 of of ADP fnp-6284 77 6 this this DET fnp-6284 77 7 study study NOUN fnp-6284 77 8 is be AUX fnp-6284 77 9 to to PART fnp-6284 77 10 systematically systematically ADV fnp-6284 77 11 identify identify VERB fnp-6284 77 12 the the DET fnp-6284 77 13 key key ADJ fnp-6284 77 14 anatomical anatomical ADJ fnp-6284 77 15 components component NOUN fnp-6284 77 16 of of ADP fnp-6284 77 17 fcd fcd NOUN fnp-6284 77 18 in in ADP fnp-6284 77 19 multiple multiple ADJ fnp-6284 77 20 tissue tissue NOUN fnp-6284 77 21 sections section NOUN fnp-6284 77 22 in in ADP fnp-6284 77 23 order order NOUN fnp-6284 77 24 to to PART fnp-6284 77 25 perform perform VERB fnp-6284 77 26 molecular molecular ADJ fnp-6284 77 27 sequencing sequencing NOUN fnp-6284 77 28 on on ADP fnp-6284 77 29 dysmorphic dysmorphic ADJ fnp-6284 77 30 neuron neuron NOUN fnp-6284 77 31 - - PUNCT fnp-6284 77 32 enriched enrich VERB fnp-6284 77 33 samples sample NOUN fnp-6284 77 34 . . PUNCT fnp-6284 78 1 to to PART fnp-6284 78 2 accomplish accomplish VERB fnp-6284 78 3 this this PRON fnp-6284 78 4 , , PUNCT fnp-6284 78 5 we we PRON fnp-6284 78 6 leveraged leverage VERB fnp-6284 78 7 unsupervised unsupervised ADJ fnp-6284 78 8 deep deep ADJ fnp-6284 78 9 learning learning NOUN fnp-6284 78 10 approaches approach NOUN fnp-6284 78 11 to to PART fnp-6284 78 12 map map VERB fnp-6284 78 13 the the DET fnp-6284 78 14 conventional conventional ADJ fnp-6284 78 15 pathological pathological ADJ fnp-6284 78 16 features feature NOUN fnp-6284 78 17 of of ADP fnp-6284 78 18 this this DET fnp-6284 78 19 disease disease NOUN fnp-6284 78 20 for for ADP fnp-6284 78 21 spatially spatially ADV fnp-6284 78 22 - - PUNCT fnp-6284 78 23 conserved conserve VERB fnp-6284 78 24 rna rna NOUN fnp-6284 78 25 - - PUNCT fnp-6284 78 26 sequencing sequence VERB fnp-6284 78 27 . . PUNCT fnp-6284 79 1 using use VERB fnp-6284 79 2 this this DET fnp-6284 79 3 approach approach NOUN fnp-6284 79 4 , , PUNCT fnp-6284 79 5 we we PRON fnp-6284 79 6 present present VERB fnp-6284 79 7 the the DET fnp-6284 79 8 highest high ADJ fnp-6284 79 9 resolution resolution NOUN fnp-6284 79 10 molecular molecular ADJ fnp-6284 79 11 catalog catalog NOUN fnp-6284 79 12 of of ADP fnp-6284 79 13 fcd fcd NOUN fnp-6284 79 14 to to ADP fnp-6284 79 15 date date NOUN fnp-6284 79 16 . . PUNCT fnp-6284 80 1 our our PRON fnp-6284 80 2 analysis analysis NOUN fnp-6284 80 3 has have AUX fnp-6284 80 4 uncovered uncover VERB fnp-6284 80 5 non non ADJ fnp-6284 80 6 - - ADJ fnp-6284 80 7 canonical canonical ADJ fnp-6284 80 8 signaling signaling NOUN fnp-6284 80 9 and and CCONJ fnp-6284 80 10 neurotransmitter neurotransmitter NOUN fnp-6284 80 11 pathways pathway NOUN fnp-6284 80 12 in in ADP fnp-6284 80 13 dysmorphic dysmorphic ADJ fnp-6284 80 14 neurons neuron NOUN fnp-6284 80 15 that that PRON fnp-6284 80 16 could could AUX fnp-6284 80 17 serve serve VERB fnp-6284 80 18 as as ADP fnp-6284 80 19 new new ADJ fnp-6284 80 20 targets target NOUN fnp-6284 80 21 for for ADP fnp-6284 80 22 this this DET fnp-6284 80 23 debilitating debilitate VERB fnp-6284 80 24 disorder disorder NOUN fnp-6284 80 25 . . PUNCT fnp-6284 81 1 specifically specifically ADV fnp-6284 81 2 , , PUNCT fnp-6284 81 3 we we PRON fnp-6284 81 4 have have AUX fnp-6284 81 5 found find VERB fnp-6284 81 6 aberrant aberrant ADJ fnp-6284 81 7 enrichment enrichment NOUN fnp-6284 81 8 of of ADP fnp-6284 81 9 an an DET fnp-6284 81 10 inhibitory inhibitory ADJ fnp-6284 81 11 glycinergic glycinergic NOUN fnp-6284 81 12 neurotransmission neurotransmission NOUN fnp-6284 81 13 regulator regulator NOUN fnp-6284 81 14 , , PUNCT fnp-6284 81 15 glycine glycine NOUN fnp-6284 81 16 transporter transporter NOUN fnp-6284 81 17 2 2 NUM fnp-6284 81 18 ( ( PUNCT fnp-6284 81 19 glyt2 glyt2 NOUN fnp-6284 81 20 ) ) PUNCT fnp-6284 81 21 . . PUNCT fnp-6284 82 1 immunohistochemical immunohistochemical ADJ fnp-6284 82 2 staining stain VERB fnp-6284 82 3 in in ADP fnp-6284 82 4 eight eight NUM fnp-6284 82 5 additional additional ADJ fnp-6284 82 6 cases case NOUN fnp-6284 82 7 of of ADP fnp-6284 82 8 fcd fcd NOUN fnp-6284 82 9 revealed reveal VERB fnp-6284 82 10 precise precise ADJ fnp-6284 82 11 enrichment enrichment NOUN fnp-6284 82 12 for for ADP fnp-6284 82 13 glyt2 glyt2 NOUN fnp-6284 82 14 in in ADP fnp-6284 82 15 dysmorphic dysmorphic ADJ fnp-6284 82 16 neurons neuron NOUN fnp-6284 82 17 . . PUNCT fnp-6284 83 1 glyt2 glyt2 NOUN fnp-6284 83 2 inhibitors inhibitor NOUN fnp-6284 83 3 have have AUX fnp-6284 83 4 demonstrated demonstrate VERB fnp-6284 83 5 efficacy efficacy NOUN fnp-6284 83 6 in in ADP fnp-6284 83 7 treating treat VERB fnp-6284 83 8 central central ADJ fnp-6284 83 9 nervous nervous ADJ fnp-6284 83 10 system system NOUN fnp-6284 83 11 disorders disorder NOUN fnp-6284 83 12 by by ADP fnp-6284 83 13 reducing reduce VERB fnp-6284 83 14 excessive excessive ADJ fnp-6284 83 15 excitatory excitatory NOUN fnp-6284 83 16 signaling signal VERB fnp-6284 83 17 , , PUNCT fnp-6284 83 18 making make VERB fnp-6284 83 19 this this PRON fnp-6284 83 20 transporter transporter VERB fnp-6284 83 21 a a DET fnp-6284 83 22 compelling compelling ADJ fnp-6284 83 23 therapeutic therapeutic ADJ fnp-6284 83 24 approach approach NOUN fnp-6284 83 25 for for ADP fnp-6284 83 26 further further ADJ fnp-6284 83 27 research research NOUN fnp-6284 83 28 in in ADP fnp-6284 83 29 fcd fcd PROPN fnp-6284 83 30 . . PUNCT fnp-6284 84 1 importantly importantly ADV fnp-6284 84 2 , , PUNCT fnp-6284 84 3 we we PRON fnp-6284 84 4 have have AUX fnp-6284 84 5 generated generate VERB fnp-6284 84 6 a a DET fnp-6284 84 7 comprehensive comprehensive ADJ fnp-6284 84 8 resource resource NOUN fnp-6284 84 9 for for ADP fnp-6284 84 10 discovery discovery NOUN fnp-6284 84 11 in in ADP fnp-6284 84 12 fcd fcd PROPN fnp-6284 84 13 , , PUNCT fnp-6284 84 14 which which PRON fnp-6284 84 15 reflects reflect VERB fnp-6284 84 16 the the DET fnp-6284 84 17 key key ADJ fnp-6284 84 18 pathologic pathologic ADJ fnp-6284 84 19 features feature NOUN fnp-6284 84 20 of of ADP fnp-6284 84 21 this this DET fnp-6284 84 22 disease disease NOUN fnp-6284 84 23 including include VERB fnp-6284 84 24 cytomegalic cytomegalic ADJ fnp-6284 84 25 dysmorphic dysmorphic ADJ fnp-6284 84 26 neurons neuron NOUN fnp-6284 84 27 , , PUNCT fnp-6284 84 28 balloon balloon NOUN fnp-6284 84 29 cells cell NOUN fnp-6284 84 30 , , PUNCT fnp-6284 84 31 and and CCONJ fnp-6284 84 32 rarefacted rarefacte VERB fnp-6284 84 33 white white ADJ fnp-6284 84 34 matter matter NOUN fnp-6284 84 35 . . PUNCT fnp-6284 85 1 we we PRON fnp-6284 85 2 anticipate anticipate VERB fnp-6284 85 3 that that SCONJ fnp-6284 85 4 the the DET fnp-6284 85 5 research research NOUN fnp-6284 85 6 and and CCONJ fnp-6284 85 7 resource resource NOUN fnp-6284 85 8 produced produce VERB fnp-6284 85 9 here here ADV fnp-6284 85 10 will will AUX fnp-6284 85 11 improve improve VERB fnp-6284 85 12 outcomes outcome NOUN fnp-6284 85 13 in in ADP fnp-6284 85 14 fcd fcd PROPN fnp-6284 85 15 . . PUNCT fnp-6284 85 16     SPACE fnp-6284 86 1 abstract abstract ADJ fnp-6284 86 2 7 7 NUM fnp-6284 86 3 free free ADJ fnp-6284 86 4 neuropathol neuropathol NOUN fnp-6284 86 5 6:1:10 6:1:10 NUM fnp-6284 86 6 transcriptomic transcriptomic ADJ fnp-6284 86 7 profiling profiling NOUN fnp-6284 86 8 reveals reveal NOUN fnp-6284 86 9 hippocampal hippocampal VERB fnp-6284 86 10 white white ADJ fnp-6284 86 11 matter matter NOUN fnp-6284 86 12 inflammation inflammation NOUN fnp-6284 86 13 as as ADP fnp-6284 86 14 potential potential ADJ fnp-6284 86 15 epileptogenic epileptogenic ADJ fnp-6284 86 16 focus focus NOUN fnp-6284 86 17 in in ADP fnp-6284 86 18 temporal temporal ADJ fnp-6284 86 19 lobe lobe NOUN fnp-6284 86 20 epilepsy epilepsy PROPN fnp-6284 86 21 xuan xuan PROPN fnp-6284 86 22 wang1 wang1 PROPN fnp-6284 86 23 , , PUNCT fnp-6284 86 24 rober rober PROPN fnp-6284 86 25 abdo1 abdo1 PROPN fnp-6284 86 26 , , PUNCT fnp-6284 86 27 carolyn carolyn PROPN fnp-6284 86 28 twible1 twible1 PROPN fnp-6284 86 29 , , PUNCT fnp-6284 86 30 chelsey chelsey PROPN fnp-6284 86 31 zhao1 zhao1 PROPN fnp-6284 86 32 , , PUNCT fnp-6284 86 33 qi qi PROPN fnp-6284 86 34 zhang1,2 zhang1,2 PROPN fnp-6284 86 35 department department NOUN fnp-6284 86 36 of of ADP fnp-6284 86 37 pathology pathology PROPN fnp-6284 86 38 and and CCONJ fnp-6284 86 39 lab lab NOUN fnp-6284 86 40 medicine medicine NOUN fnp-6284 86 41 , , PUNCT fnp-6284 86 42 western western ADJ fnp-6284 86 43 university university NOUN fnp-6284 86 44 , , PUNCT fnp-6284 86 45 london london PROPN fnp-6284 86 46 , , PUNCT fnp-6284 86 47 ontario ontario PROPN fnp-6284 86 48 , , PUNCT fnp-6284 86 49 canada canada PROPN fnp-6284 86 50 department department PROPN fnp-6284 86 51 of of ADP fnp-6284 86 52 pathology pathology PROPN fnp-6284 86 53 and and CCONJ fnp-6284 86 54 lab lab NOUN fnp-6284 86 55 medicine medicine NOUN fnp-6284 86 56 , , PUNCT fnp-6284 86 57 london london PROPN fnp-6284 86 58 health health PROPN fnp-6284 86 59 sciences sciences PROPN fnp-6284 86 60 center center PROPN fnp-6284 86 61 , , PUNCT fnp-6284 86 62 london london PROPN fnp-6284 86 63 , , PUNCT fnp-6284 86 64 ontario ontario PROPN fnp-6284 86 65 , , PUNCT fnp-6284 86 66 canada canada PROPN fnp-6284 86 67 rationale rationale NOUN fnp-6284 86 68 : : PUNCT fnp-6284 86 69 hippocampal hippocampal ADJ fnp-6284 86 70 sclerosis sclerosis NOUN fnp-6284 86 71 ( ( PUNCT fnp-6284 86 72 hs hs X fnp-6284 86 73 ) ) PUNCT fnp-6284 86 74 is be AUX fnp-6284 86 75 the the DET fnp-6284 86 76 most most ADV fnp-6284 86 77 common common ADJ fnp-6284 86 78 pathological pathological ADJ fnp-6284 86 79 finding finding NOUN fnp-6284 86 80 in in ADP fnp-6284 86 81 surgically surgically ADV fnp-6284 86 82 resected resect VERB fnp-6284 86 83 brain brain NOUN fnp-6284 86 84 tissue tissue NOUN fnp-6284 86 85 in in ADP fnp-6284 86 86 mesial mesial ADJ fnp-6284 86 87 temporal temporal ADJ fnp-6284 86 88 lobe lobe NOUN fnp-6284 86 89 epilepsy epilepsy NOUN fnp-6284 86 90 ( ( PUNCT fnp-6284 86 91 mtle mtle NOUN fnp-6284 86 92 ) ) PUNCT fnp-6284 86 93 . . PUNCT fnp-6284 87 1 the the DET fnp-6284 87 2 histopathologic histopathologic PROPN fnp-6284 87 3 hallmark hallmark NOUN fnp-6284 87 4 of of ADP fnp-6284 87 5 hs hs PROPN fnp-6284 87 6 is be AUX fnp-6284 87 7 pyramidal pyramidal ADJ fnp-6284 87 8 neuronal neuronal ADJ fnp-6284 87 9 loss loss NOUN fnp-6284 87 10 within within ADP fnp-6284 87 11 the the DET fnp-6284 87 12 cornu cornu NOUN fnp-6284 87 13 ammonis ammonis X fnp-6284 87 14 ( ( PUNCT fnp-6284 87 15 ca ca NOUN fnp-6284 87 16 ) ) PUNCT fnp-6284 87 17 sectors sector NOUN fnp-6284 87 18 . . PUNCT fnp-6284 88 1 twenty twenty NUM fnp-6284 88 2 percent percent NOUN fnp-6284 88 3 of of ADP fnp-6284 88 4 tle tle NOUN fnp-6284 88 5 cases case NOUN fnp-6284 88 6 have have VERB fnp-6284 88 7 no no DET fnp-6284 88 8 significant significant ADJ fnp-6284 88 9 neuronal neuronal ADJ fnp-6284 88 10 loss loss NOUN fnp-6284 88 11 ( ( PUNCT fnp-6284 88 12 no no NOUN fnp-6284 88 13 - - PUNCT fnp-6284 88 14 hs hs ADJ fnp-6284 88 15 , , PUNCT fnp-6284 88 16 ilae ilae NOUN fnp-6284 88 17 type type NOUN fnp-6284 88 18 4 4 NUM fnp-6284 88 19 ) ) PUNCT fnp-6284 88 20 . . PUNCT fnp-6284 89 1 about about ADV fnp-6284 89 2 40 40 NUM fnp-6284 89 3     SPACE fnp-6284 89 4 % % NOUN fnp-6284 89 5 of of ADP fnp-6284 89 6 no no DET fnp-6284 89 7 - - PUNCT fnp-6284 89 8 hs hs PROPN fnp-6284 89 9 patients patient NOUN fnp-6284 89 10 achieve achieve VERB fnp-6284 89 11 seizure seizure NOUN fnp-6284 89 12 freedom freedom NOUN fnp-6284 89 13 post post NOUN fnp-6284 89 14 - - ADJ fnp-6284 89 15 operatively operatively ADV fnp-6284 89 16 . . PUNCT fnp-6284 90 1 objectives objective NOUN fnp-6284 90 2 : : PUNCT fnp-6284 90 3 we we PRON fnp-6284 90 4 performed perform VERB fnp-6284 90 5 spatial spatial ADJ fnp-6284 90 6 transcriptomic transcriptomic ADJ fnp-6284 90 7 profiling profiling NOUN fnp-6284 90 8 of of ADP fnp-6284 90 9 no no DET fnp-6284 90 10 - - PUNCT fnp-6284 90 11 hs hs NOUN fnp-6284 90 12 hippocampi hippocampi ADJ fnp-6284 90 13 to to PART fnp-6284 90 14 identify identify VERB fnp-6284 90 15 molecular molecular ADJ fnp-6284 90 16 changes change NOUN fnp-6284 90 17 associated associate VERB fnp-6284 90 18 with with ADP fnp-6284 90 19 post post ADJ fnp-6284 90 20 - - ADJ fnp-6284 90 21 operative operative ADJ fnp-6284 90 22 outcomes outcome NOUN fnp-6284 90 23 . . PUNCT fnp-6284 91 1 method method NOUN fnp-6284 91 2 : : PUNCT fnp-6284 91 3 eight eight NUM fnp-6284 91 4 no no NOUN fnp-6284 91 5 - - PUNCT fnp-6284 91 6 hs hs NOUN fnp-6284 91 7 hippocampi hippocampi ADJ fnp-6284 91 8 were be AUX fnp-6284 91 9 obtained obtain VERB fnp-6284 91 10 from from ADP fnp-6284 91 11 the the DET fnp-6284 91 12 department department NOUN fnp-6284 91 13 of of ADP fnp-6284 91 14 pathology pathology PROPN fnp-6284 91 15 at at ADP fnp-6284 91 16 lhsc lhsc PROPN fnp-6284 91 17 . . PUNCT fnp-6284 92 1 five five NUM fnp-6284 92 2 patients patient NOUN fnp-6284 92 3 had have VERB fnp-6284 92 4 engel engel PROPN fnp-6284 92 5 1a 1a PROPN fnp-6284 92 6 outcome outcome NOUN fnp-6284 92 7 ( ( PUNCT fnp-6284 92 8 seizure seizure VERB fnp-6284 92 9 free free ADJ fnp-6284 92 10 , , PUNCT fnp-6284 92 11 sf sf PROPN fnp-6284 92 12 ) ) PUNCT fnp-6284 92 13 ; ; PUNCT fnp-6284 92 14 three three NUM fnp-6284 92 15 patients patient NOUN fnp-6284 92 16 with with ADP fnp-6284 92 17 engel engel PROPN fnp-6284 92 18 outcome outcome VERB fnp-6284 92 19 2–4 2–4 NUM fnp-6284 92 20 ( ( PUNCT fnp-6284 92 21 non non ADJ fnp-6284 92 22 - - ADJ fnp-6284 92 23 seizure seizure ADJ fnp-6284 92 24 free free ADJ fnp-6284 92 25 , , PUNCT fnp-6284 92 26 nsf nsf NOUN fnp-6284 92 27 ) ) PUNCT fnp-6284 92 28 . . PUNCT fnp-6284 93 1 six six NUM fnp-6284 93 2 samples sample NOUN fnp-6284 93 3 ( ( PUNCT fnp-6284 93 4 3 3 NUM fnp-6284 93 5 sf sf NOUN fnp-6284 93 6 and and CCONJ fnp-6284 93 7 3 3 NUM fnp-6284 93 8 nsf nsf NOUN fnp-6284 93 9 ) ) PUNCT fnp-6284 93 10 were be AUX fnp-6284 93 11 selected select VERB fnp-6284 93 12 based base VERB fnp-6284 93 13 on on ADP fnp-6284 93 14 anatomical anatomical ADJ fnp-6284 93 15 integrity integrity NOUN fnp-6284 93 16 and and CCONJ fnp-6284 93 17 rna rna NOUN fnp-6284 93 18 quality quality NOUN fnp-6284 93 19 . . PUNCT fnp-6284 94 1 spatial spatial ADJ fnp-6284 94 2 transcriptomic transcriptomic ADJ fnp-6284 94 3 profiling profiling NOUN fnp-6284 94 4 was be AUX fnp-6284 94 5 performed perform VERB fnp-6284 94 6 using use VERB fnp-6284 94 7 10x 10x NOUN fnp-6284 94 8 genomics genomics NOUN fnp-6284 94 9 visium visium NOUN fnp-6284 94 10 technology technology PROPN fnp-6284 94 11 . . PUNCT fnp-6284 95 1 data datum NOUN fnp-6284 95 2 analysis analysis NOUN fnp-6284 95 3 was be AUX fnp-6284 95 4 conducted conduct VERB fnp-6284 95 5 using use VERB fnp-6284 95 6 the the DET fnp-6284 95 7 loupe loupe ADJ fnp-6284 95 8 browser browser NOUN fnp-6284 95 9 and and CCONJ fnp-6284 95 10 r r NOUN fnp-6284 95 11 / / SYM fnp-6284 95 12 bioconductor bioconductor NOUN fnp-6284 95 13 packages package NOUN fnp-6284 95 14 to to PART fnp-6284 95 15 compare compare VERB fnp-6284 95 16 gene gene NOUN fnp-6284 95 17 expression expression NOUN fnp-6284 95 18 across across ADP fnp-6284 95 19 various various ADJ fnp-6284 95 20 hippocampal hippocampal ADJ fnp-6284 95 21 regions region NOUN fnp-6284 95 22 . . PUNCT fnp-6284 96 1 results result NOUN fnp-6284 96 2 : : PUNCT fnp-6284 96 3 unsupervised unsupervised ADJ fnp-6284 96 4 data data NOUN fnp-6284 96 5 - - PUNCT fnp-6284 96 6 driven drive VERB fnp-6284 96 7 clustering clustering NOUN fnp-6284 96 8 ( ( PUNCT fnp-6284 96 9 bayesspace bayesspace NOUN fnp-6284 96 10 ) ) PUNCT fnp-6284 96 11 correlates correlate VERB fnp-6284 96 12 well well ADV fnp-6284 96 13 with with ADP fnp-6284 96 14 histology histology NOUN fnp-6284 96 15 based base VERB fnp-6284 96 16 manual manual ADJ fnp-6284 96 17 annotation annotation NOUN fnp-6284 96 18 . . PUNCT fnp-6284 97 1 two two NUM fnp-6284 97 2 distinct distinct ADJ fnp-6284 97 3 spatial spatial ADJ fnp-6284 97 4 domains domain NOUN fnp-6284 97 5 ( ( PUNCT fnp-6284 97 6 cluster cluster NOUN fnp-6284 97 7 7 7 NUM fnp-6284 97 8 and and CCONJ fnp-6284 97 9 8) 8) NUM fnp-6284 97 10 were be AUX fnp-6284 97 11 identified identify VERB fnp-6284 97 12 in in ADP fnp-6284 97 13 hippocampal hippocampal ADJ fnp-6284 97 14 ca1 ca1 PROPN fnp-6284 97 15 region region PROPN fnp-6284 97 16 . . PUNCT fnp-6284 98 1 differential differential ADJ fnp-6284 98 2 expression expression NOUN fnp-6284 98 3 analysis analysis NOUN fnp-6284 98 4 identified identify VERB fnp-6284 98 5 upregulated upregulate VERB fnp-6284 98 6 neuroinflammation neuroinflammation NOUN fnp-6284 98 7 genes gene NOUN fnp-6284 98 8 in in ADP fnp-6284 98 9 the the DET fnp-6284 98 10 seizure seizure ADJ fnp-6284 98 11 free free ADJ fnp-6284 98 12 group group NOUN fnp-6284 98 13 , , PUNCT fnp-6284 98 14 predominantly predominantly ADV fnp-6284 98 15 in in ADP fnp-6284 98 16 the the DET fnp-6284 98 17 hippocampal hippocampal ADJ fnp-6284 98 18 white white ADJ fnp-6284 98 19 matter matter NOUN fnp-6284 98 20 ( ( PUNCT fnp-6284 98 21 e.g. e.g. ADV fnp-6284 98 22 stratum stratum VERB fnp-6284 98 23 radiatum radiatum NOUN fnp-6284 98 24 ) ) PUNCT fnp-6284 98 25 . . PUNCT fnp-6284 99 1 trajectory trajectory NOUN fnp-6284 99 2 analysis analysis NOUN fnp-6284 99 3 indicated indicate VERB fnp-6284 99 4 disease disease NOUN fnp-6284 99 5 spatial spatial ADJ fnp-6284 99 6 progression progression NOUN fnp-6284 99 7 starting start VERB fnp-6284 99 8 from from ADP fnp-6284 99 9 hippocampal hippocampal ADJ fnp-6284 99 10 white white ADJ fnp-6284 99 11 matter matter NOUN fnp-6284 99 12 , , PUNCT fnp-6284 99 13 progressing progress VERB fnp-6284 99 14 to to AUX fnp-6284 99 15 ca ca VERB fnp-6284 99 16 sectors sector NOUN fnp-6284 99 17 , , PUNCT fnp-6284 99 18 and and CCONJ fnp-6284 99 19 reaching reach VERB fnp-6284 99 20 the the DET fnp-6284 99 21 dentate dentate ADJ fnp-6284 99 22 gyrus gyrus NOUN fnp-6284 99 23 at at ADP fnp-6284 99 24 the the DET fnp-6284 99 25 end end NOUN fnp-6284 99 26 . . PUNCT fnp-6284 100 1 conclusions conclusion NOUN fnp-6284 100 2 : : PUNCT fnp-6284 100 3 our our PRON fnp-6284 100 4 findings finding NOUN fnp-6284 100 5 suggest suggest VERB fnp-6284 100 6 molecular molecular ADJ fnp-6284 100 7 heterogeneity heterogeneity NOUN fnp-6284 100 8 of of ADP fnp-6284 100 9 the the DET fnp-6284 100 10 human human PROPN fnp-6284 100 11 ca1 ca1 PROPN fnp-6284 100 12 sector sector NOUN fnp-6284 100 13 . . PUNCT fnp-6284 101 1 patient patient NOUN fnp-6284 101 2 who who PRON fnp-6284 101 3 had have VERB fnp-6284 101 4 better well ADJ fnp-6284 101 5 post post ADJ fnp-6284 101 6 - - ADJ fnp-6284 101 7 surgical surgical ADJ fnp-6284 101 8 outcomes outcome NOUN fnp-6284 101 9 possess possess VERB fnp-6284 101 10 elevated elevated ADJ fnp-6284 101 11 neuroinflammatory neuroinflammatory ADJ fnp-6284 101 12 signature signature NOUN fnp-6284 101 13 in in ADP fnp-6284 101 14 the the DET fnp-6284 101 15 hippocampal hippocampal ADJ fnp-6284 101 16 white white ADJ fnp-6284 101 17 matter matter NOUN fnp-6284 101 18 . . PUNCT fnp-6284 101 19     SPACE fnp-6284 102 1 abstract abstract ADJ fnp-6284 102 2 8 8 NUM fnp-6284 102 3 free free ADJ fnp-6284 102 4 neuropathol neuropathol NOUN fnp-6284 102 5 6:1:11 6:1:11 NUM fnp-6284 102 6 global global ADJ fnp-6284 102 7 proteomics proteomic NOUN fnp-6284 102 8 reveals reveal VERB fnp-6284 102 9 bidirectional bidirectional ADJ fnp-6284 102 10 integrin integrin NOUN fnp-6284 102 11 signaling signal VERB fnp-6284 102 12 as as ADP fnp-6284 102 13 a a DET fnp-6284 102 14 driver driver NOUN fnp-6284 102 15 of of ADP fnp-6284 102 16 glioblastoma glioblastoma NOUN fnp-6284 102 17 invasion invasion NOUN fnp-6284 102 18 rifat rifat PROPN fnp-6284 102 19 s. s. PROPN fnp-6284 102 20 sajid1 sajid1 PROPN fnp-6284 102 21 , , PUNCT fnp-6284 102 22 lennart lennart PROPN fnp-6284 102 23 j. j. PROPN fnp-6284 102 24 van van PROPN fnp-6284 102 25 winden2 winden2 PROPN fnp-6284 102 26 , , PUNCT fnp-6284 102 27 nakita nakita PROPN fnp-6284 102 28 gopal1 gopal1 PROPN fnp-6284 102 29 , , PUNCT fnp-6284 102 30 evelyn evelyn PROPN fnp-6284 102 31 r. r. PROPN fnp-6284 102 32 kamski kamski PROPN fnp-6284 102 33 - - PUNCT fnp-6284 102 34 hennekam2 hennekam2 PROPN fnp-6284 102 35 , , PUNCT fnp-6284 102 36 okty okty PROPN fnp-6284 102 37 abbasi abbasi PROPN fnp-6284 102 38 borhani2 borhani2 PROPN fnp-6284 102 39 , , PUNCT fnp-6284 102 40 ameesha ameesha PROPN fnp-6284 102 41 paliwal1 paliwal1 PROPN fnp-6284 102 42 , , PUNCT fnp-6284 102 43 phedias phedias PROPN fnp-6284 102 44 diamandis1–4 diamandis1–4 PROPN fnp-6284 102 45 department department PROPN fnp-6284 102 46 of of ADP fnp-6284 102 47 laboratory laboratory NOUN fnp-6284 102 48 medicine medicine NOUN fnp-6284 102 49 and and CCONJ fnp-6284 102 50 pathobiology pathobiology NOUN fnp-6284 102 51 , , PUNCT fnp-6284 102 52 university university PROPN fnp-6284 102 53 of of ADP fnp-6284 102 54 toronto toronto PROPN fnp-6284 102 55 , , PUNCT fnp-6284 102 56 toronto toronto PROPN fnp-6284 102 57 , , PUNCT fnp-6284 102 58 canada canada PROPN fnp-6284 102 59 princess princess PROPN fnp-6284 102 60 margaret margaret PROPN fnp-6284 102 61 cancer cancer PROPN fnp-6284 102 62 centre centre PROPN fnp-6284 102 63 , , PUNCT fnp-6284 102 64 toronto toronto PROPN fnp-6284 102 65 , , PUNCT fnp-6284 102 66 canada canada PROPN fnp-6284 102 67 laboratory laboratory PROPN fnp-6284 102 68 medicine medicine PROPN fnp-6284 102 69 program program NOUN fnp-6284 102 70 , , PUNCT fnp-6284 102 71 university university NOUN fnp-6284 102 72 health health NOUN fnp-6284 102 73 network network NOUN fnp-6284 102 74 , , PUNCT fnp-6284 102 75 toronto toronto PROPN fnp-6284 102 76 , , PUNCT fnp-6284 102 77 canada canada PROPN fnp-6284 102 78 department department PROPN fnp-6284 102 79 of of ADP fnp-6284 102 80 medical medical ADJ fnp-6284 102 81 biophysics biophysic NOUN fnp-6284 102 82 , , PUNCT fnp-6284 102 83 university university PROPN fnp-6284 102 84 of of ADP fnp-6284 102 85 toronto toronto PROPN fnp-6284 102 86 , , PUNCT fnp-6284 102 87 toronto toronto PROPN fnp-6284 102 88 , , PUNCT fnp-6284 102 89 canada canada PROPN fnp-6284 102 90 glioblastoma glioblastoma PROPN fnp-6284 102 91 ( ( PUNCT fnp-6284 102 92 gbm gbm PROPN fnp-6284 102 93 ) ) PUNCT fnp-6284 102 94 is be AUX fnp-6284 102 95 the the DET fnp-6284 102 96 most most ADV fnp-6284 102 97 aggressive aggressive ADJ fnp-6284 102 98 form form NOUN fnp-6284 102 99 of of ADP fnp-6284 102 100 adult adult NOUN fnp-6284 102 101 brain brain NOUN fnp-6284 102 102 cancer cancer NOUN fnp-6284 102 103 with with ADP fnp-6284 102 104 a a DET fnp-6284 102 105 median median ADJ fnp-6284 102 106 survival survival NOUN fnp-6284 102 107 of of ADP fnp-6284 102 108 15 15 NUM fnp-6284 102 109 months month NOUN fnp-6284 102 110 despite despite SCONJ fnp-6284 102 111 multimodal multimodal NOUN fnp-6284 102 112 treatment treatment NOUN fnp-6284 102 113 . . PUNCT fnp-6284 103 1 a a DET fnp-6284 103 2 significant significant ADJ fnp-6284 103 3 treatment treatment NOUN fnp-6284 103 4 challenge challenge NOUN fnp-6284 103 5 is be AUX fnp-6284 103 6 the the DET fnp-6284 103 7 ability ability NOUN fnp-6284 103 8 of of ADP fnp-6284 103 9 tumour tumour NOUN fnp-6284 103 10 cells cell NOUN fnp-6284 103 11 to to PART fnp-6284 103 12 infiltrate infiltrate VERB fnp-6284 103 13 into into ADP fnp-6284 103 14 surrounding surround VERB fnp-6284 103 15 brain brain NOUN fnp-6284 103 16 tissue tissue NOUN fnp-6284 103 17 . . PUNCT fnp-6284 104 1 recent recent ADJ fnp-6284 104 2 studies study NOUN fnp-6284 104 3 have have AUX fnp-6284 104 4 revealed reveal VERB fnp-6284 104 5 an an DET fnp-6284 104 6 enrichment enrichment NOUN fnp-6284 104 7 of of ADP fnp-6284 104 8 hypoxia hypoxia NOUN fnp-6284 104 9 - - PUNCT fnp-6284 104 10 associated associate VERB fnp-6284 104 11 signatures signature NOUN fnp-6284 104 12 in in ADP fnp-6284 104 13 invasive invasive ADJ fnp-6284 104 14 gbm gbm NOUN fnp-6284 104 15 cells cell NOUN fnp-6284 104 16 and and CCONJ fnp-6284 104 17 that that SCONJ fnp-6284 104 18 tumour tumour NOUN fnp-6284 104 19 cells cell NOUN fnp-6284 104 20 actively actively ADV fnp-6284 104 21 migrate migrate VERB fnp-6284 104 22 away away ADV fnp-6284 104 23 from from ADP fnp-6284 104 24 hypoxic hypoxic ADJ fnp-6284 104 25 areas area NOUN fnp-6284 104 26 to to ADP fnp-6284 104 27 distant distant ADJ fnp-6284 104 28 brain brain NOUN fnp-6284 104 29 regions region NOUN fnp-6284 104 30 . . PUNCT fnp-6284 105 1 while while SCONJ fnp-6284 105 2 these these DET fnp-6284 105 3 studies study NOUN fnp-6284 105 4 have have AUX fnp-6284 105 5 advanced advance VERB fnp-6284 105 6 our our PRON fnp-6284 105 7 understanding understanding NOUN fnp-6284 105 8 of of ADP fnp-6284 105 9 gbm gbm PROPN fnp-6284 105 10 invasion invasion NOUN fnp-6284 105 11 , , PUNCT fnp-6284 105 12 the the DET fnp-6284 105 13 significant significant ADJ fnp-6284 105 14 heterogeneity heterogeneity NOUN fnp-6284 105 15 of of ADP fnp-6284 105 16 clinical clinical ADJ fnp-6284 105 17 tissue tissue NOUN fnp-6284 105 18 samples sample NOUN fnp-6284 105 19 makes make VERB fnp-6284 105 20 it it PRON fnp-6284 105 21 difficult difficult ADJ fnp-6284 105 22 to to PART fnp-6284 105 23 prioritize prioritize VERB fnp-6284 105 24 migratory migratory NOUN fnp-6284 105 25 signaling signal VERB fnp-6284 105 26 pathways pathway NOUN fnp-6284 105 27 for for ADP fnp-6284 105 28 therapeutic therapeutic ADJ fnp-6284 105 29 targeting targeting NOUN fnp-6284 105 30 . . PUNCT fnp-6284 106 1 therefore therefore ADV fnp-6284 106 2 , , PUNCT fnp-6284 106 3 we we PRON fnp-6284 106 4 utilized utilize VERB fnp-6284 106 5 a a DET fnp-6284 106 6 diverse diverse ADJ fnp-6284 106 7 cohort cohort NOUN fnp-6284 106 8 of of ADP fnp-6284 106 9 patient patient ADJ fnp-6284 106 10 derived derive VERB fnp-6284 106 11 gbm gbm NOUN fnp-6284 106 12 stem stem NOUN fnp-6284 106 13 cell cell NOUN fnp-6284 106 14 ( ( PUNCT fnp-6284 106 15 gsc gsc NOUN fnp-6284 106 16 ) ) PUNCT fnp-6284 106 17 lines line NOUN fnp-6284 106 18 and and CCONJ fnp-6284 106 19 experimental experimental ADJ fnp-6284 106 20 systems system NOUN fnp-6284 106 21 to to PART fnp-6284 106 22 stimulate stimulate VERB fnp-6284 106 23 more more ADV fnp-6284 106 24 controlled control VERB fnp-6284 106 25 invasion invasion NOUN fnp-6284 106 26 models model NOUN fnp-6284 106 27 and and CCONJ fnp-6284 106 28 identify identify VERB fnp-6284 106 29 targets target NOUN fnp-6284 106 30 to to PART fnp-6284 106 31 impede impede VERB fnp-6284 106 32 tumour tumour NOUN fnp-6284 106 33 infiltration infiltration NOUN fnp-6284 106 34 . . PUNCT fnp-6284 107 1 to to PART fnp-6284 107 2 investigate investigate VERB fnp-6284 107 3 these these DET fnp-6284 107 4 signaling signal VERB fnp-6284 107 5 pathways pathway NOUN fnp-6284 107 6 , , PUNCT fnp-6284 107 7 we we PRON fnp-6284 107 8 leveraged leverage VERB fnp-6284 107 9 mass mass NOUN fnp-6284 107 10 spectrometry spectrometry NOUN fnp-6284 107 11 - - PUNCT fnp-6284 107 12 based base VERB fnp-6284 107 13 proteomics proteomic NOUN fnp-6284 107 14 to to PART fnp-6284 107 15 profile profile VERB fnp-6284 107 16 gscs gsc NOUN fnp-6284 107 17 cultured cultured ADJ fnp-6284 107 18 under under ADP fnp-6284 107 19 varying vary VERB fnp-6284 107 20 oxygen oxygen NOUN fnp-6284 107 21 concentrations concentration NOUN fnp-6284 107 22 . . PUNCT fnp-6284 108 1 this this DET fnp-6284 108 2 analysis analysis NOUN fnp-6284 108 3 revealed reveal VERB fnp-6284 108 4 the the DET fnp-6284 108 5 enrichment enrichment NOUN fnp-6284 108 6 of of ADP fnp-6284 108 7 integrin integrin NOUN fnp-6284 108 8 - - PUNCT fnp-6284 108 9 related relate VERB fnp-6284 108 10 signaling signal VERB fnp-6284 108 11 pathways pathway NOUN fnp-6284 108 12 in in ADP fnp-6284 108 13 hypoxia hypoxia NOUN fnp-6284 108 14 . . PUNCT fnp-6284 109 1 next next ADV fnp-6284 109 2 , , PUNCT fnp-6284 109 3 we we PRON fnp-6284 109 4 utilized utilize VERB fnp-6284 109 5 the the DET fnp-6284 109 6 gsc gsc PROPN fnp-6284 109 7 and and CCONJ fnp-6284 109 8 cerebral cerebral ADJ fnp-6284 109 9 organoid organoid NOUN fnp-6284 109 10 ( ( PUNCT fnp-6284 109 11 glico glico NOUN fnp-6284 109 12 ) ) PUNCT fnp-6284 109 13 co co NOUN fnp-6284 109 14 - - NOUN fnp-6284 109 15 culture culture ADJ fnp-6284 109 16 model model NOUN fnp-6284 109 17 of of ADP fnp-6284 109 18 gbm gbm PROPN fnp-6284 109 19 brain brain NOUN fnp-6284 109 20 infiltration infiltration NOUN fnp-6284 109 21 to to PART fnp-6284 109 22 investigate investigate VERB fnp-6284 109 23 hypoxia hypoxia NOUN fnp-6284 109 24 - - PUNCT fnp-6284 109 25 independent independent ADJ fnp-6284 109 26 gbm gbm NOUN fnp-6284 109 27 invasion invasion NOUN fnp-6284 109 28 and and CCONJ fnp-6284 109 29 discovered discover VERB fnp-6284 109 30 the the DET fnp-6284 109 31 upregulation upregulation NOUN fnp-6284 109 32 of of ADP fnp-6284 109 33 proteins protein NOUN fnp-6284 109 34 involved involve VERB fnp-6284 109 35 in in ADP fnp-6284 109 36 both both PRON fnp-6284 109 37 outside outside NOUN fnp-6284 109 38 - - PUNCT fnp-6284 109 39 in in NOUN fnp-6284 109 40 and and CCONJ fnp-6284 109 41 inside inside ADV fnp-6284 109 42 - - PUNCT fnp-6284 109 43 out out ADP fnp-6284 109 44 integrin integrin NOUN fnp-6284 109 45 signaling signal VERB fnp-6284 109 46 pathways pathway NOUN fnp-6284 109 47 . . PUNCT fnp-6284 110 1 we we PRON fnp-6284 110 2 then then ADV fnp-6284 110 3 spatially spatially ADV fnp-6284 110 4 correlated correlate VERB fnp-6284 110 5 this this DET fnp-6284 110 6 increased increase VERB fnp-6284 110 7 expression expression NOUN fnp-6284 110 8 in in ADP fnp-6284 110 9 gscs gsc NOUN fnp-6284 110 10 through through ADP fnp-6284 110 11 spatial spatial ADJ fnp-6284 110 12 transcriptomics transcriptomic NOUN fnp-6284 110 13 . . PUNCT fnp-6284 111 1 finally finally ADV fnp-6284 111 2 , , PUNCT fnp-6284 111 3 we we PRON fnp-6284 111 4 functionally functionally ADV fnp-6284 111 5 evaluated evaluate VERB fnp-6284 111 6 the the DET fnp-6284 111 7 role role NOUN fnp-6284 111 8 of of ADP fnp-6284 111 9 integrin integrin NOUN fnp-6284 111 10 signaling signal VERB fnp-6284 111 11 in in ADP fnp-6284 111 12 gbm gbm PROPN fnp-6284 111 13 invasion invasion NOUN fnp-6284 111 14 through through ADP fnp-6284 111 15 pharmacological pharmacological ADJ fnp-6284 111 16 inhibition inhibition NOUN fnp-6284 111 17 in in ADP fnp-6284 111 18 glicos glico NOUN fnp-6284 111 19 , , PUNCT fnp-6284 111 20 which which PRON fnp-6284 111 21 resulted result VERB fnp-6284 111 22 in in ADP fnp-6284 111 23 significantly significantly ADV fnp-6284 111 24 reduced reduce VERB fnp-6284 111 25 gsc gsc PROPN fnp-6284 111 26 infiltration infiltration NOUN fnp-6284 111 27 . . PUNCT fnp-6284 112 1 therefore therefore ADV fnp-6284 112 2 , , PUNCT fnp-6284 112 3 this this DET fnp-6284 112 4 study study NOUN fnp-6284 112 5 highlights highlight VERB fnp-6284 112 6 the the DET fnp-6284 112 7 pivotal pivotal ADJ fnp-6284 112 8 role role NOUN fnp-6284 112 9 of of ADP fnp-6284 112 10 bidirectional bidirectional ADJ fnp-6284 112 11 integrin integrin NOUN fnp-6284 112 12 signaling signal VERB fnp-6284 112 13 as as ADP fnp-6284 112 14 a a DET fnp-6284 112 15 driver driver NOUN fnp-6284 112 16 of of ADP fnp-6284 112 17 gbm gbm PROPN fnp-6284 112 18 invasion invasion NOUN fnp-6284 112 19 , , PUNCT fnp-6284 112 20 and and CCONJ fnp-6284 112 21 further further ADJ fnp-6284 112 22 exploration exploration NOUN fnp-6284 112 23 of of ADP fnp-6284 112 24 key key ADJ fnp-6284 112 25 regulators regulator NOUN fnp-6284 112 26 presents present VERB fnp-6284 112 27 a a DET fnp-6284 112 28 promising promising ADJ fnp-6284 112 29 therapeutic therapeutic ADJ fnp-6284 112 30 avenue avenue NOUN fnp-6284 112 31 . . PUNCT fnp-6284 112 32     SPACE fnp-6284 113 1 abstract abstract ADJ fnp-6284 113 2 9 9 NUM fnp-6284 113 3 free free ADJ fnp-6284 113 4 neuropathol neuropathol NOUN fnp-6284 113 5 6:1:12 6:1:12 NUM fnp-6284 113 6 integration integration NOUN fnp-6284 113 7 of of ADP fnp-6284 113 8 molecular molecular ADJ fnp-6284 113 9 and and CCONJ fnp-6284 113 10 morphometric morphometric ADJ fnp-6284 113 11 features feature NOUN fnp-6284 113 12 improves improve VERB fnp-6284 113 13 prognostication prognostication NOUN fnp-6284 113 14 of of ADP fnp-6284 113 15 diffuse diffuse ADJ fnp-6284 113 16 gliomas glioma NOUN fnp-6284 113 17 dimitrios dimitrio NOUN fnp-6284 113 18 g. g. PROPN fnp-6284 113 19 oreopoulos1,2 oreopoulos1,2 PROPN fnp-6284 113 20 , , PUNCT fnp-6284 113 21 ameesha ameesha PROPN fnp-6284 113 22 paliwal2 paliwal2 PROPN fnp-6284 113 23 , , PUNCT fnp-6284 113 24 parsa parsa PROPN fnp-6284 113 25 babaei babaei PROPN fnp-6284 113 26 - - PUNCT fnp-6284 113 27 zadeh2 zadeh2 PROPN fnp-6284 113 28 , , PUNCT fnp-6284 113 29 alberto alberto PROPN fnp-6284 113 30 leon2 leon2 NOUN fnp-6284 113 31 , , PUNCT fnp-6284 113 32 kevin kevin PROPN fnp-6284 113 33 faust2 faust2 PROPN fnp-6284 113 34 , , PUNCT fnp-6284 113 35 phedias phedia VERB fnp-6284 113 36 diamandis2–4 diamandis2–4 PROPN fnp-6284 113 37 temerty temerty NOUN fnp-6284 113 38 centre centre NOUN fnp-6284 113 39 for for ADP fnp-6284 113 40 artificial artificial ADJ fnp-6284 113 41 intelligence intelligence NOUN fnp-6284 113 42 research research NOUN fnp-6284 113 43 and and CCONJ fnp-6284 113 44 education education NOUN fnp-6284 113 45 in in ADP fnp-6284 113 46 medicine medicine NOUN fnp-6284 113 47 , , PUNCT fnp-6284 113 48 university university PROPN fnp-6284 113 49 of of ADP fnp-6284 113 50 toronto toronto PROPN fnp-6284 113 51 , , PUNCT fnp-6284 113 52 toronto toronto PROPN fnp-6284 113 53 , , PUNCT fnp-6284 113 54 on on ADP fnp-6284 113 55 , , PUNCT fnp-6284 113 56 canada canada PROPN fnp-6284 113 57 department department PROPN fnp-6284 113 58 of of ADP fnp-6284 113 59 pathology pathology PROPN fnp-6284 113 60 , , PUNCT fnp-6284 113 61 princess princess PROPN fnp-6284 113 62 margaret margaret PROPN fnp-6284 113 63 cancer cancer PROPN fnp-6284 113 64 centre centre PROPN fnp-6284 113 65 , , PUNCT fnp-6284 113 66 101 101 NUM fnp-6284 113 67 college college PROPN fnp-6284 113 68 street street PROPN fnp-6284 113 69 , , PUNCT fnp-6284 113 70 toronto toronto PROPN fnp-6284 113 71 , , PUNCT fnp-6284 113 72 on on ADP fnp-6284 113 73 , , PUNCT fnp-6284 113 74 m5 m5 PROPN fnp-6284 113 75 g g NOUN fnp-6284 113 76 1l7 1l7 NUM fnp-6284 113 77 , , PUNCT fnp-6284 113 78 canada canada PROPN fnp-6284 113 79 department department PROPN fnp-6284 113 80 of of ADP fnp-6284 113 81 laboratory laboratory NOUN fnp-6284 113 82 medicine medicine NOUN fnp-6284 113 83 and and CCONJ fnp-6284 113 84 pathobiology pathobiology NOUN fnp-6284 113 85 , , PUNCT fnp-6284 113 86 university university PROPN fnp-6284 113 87 of of ADP fnp-6284 113 88 toronto toronto PROPN fnp-6284 113 89 , , PUNCT fnp-6284 113 90 toronto toronto PROPN fnp-6284 113 91 , , PUNCT fnp-6284 113 92 on on ADP fnp-6284 113 93 , , PUNCT fnp-6284 113 94 canada canada PROPN fnp-6284 113 95 department department PROPN fnp-6284 113 96 of of ADP fnp-6284 113 97 medical medical ADJ fnp-6284 113 98 biophysics biophysic NOUN fnp-6284 113 99 , , PUNCT fnp-6284 113 100 university university PROPN fnp-6284 113 101 of of ADP fnp-6284 113 102 toronto toronto PROPN fnp-6284 113 103 , , PUNCT fnp-6284 113 104 toronto toronto PROPN fnp-6284 113 105 , , PUNCT fnp-6284 113 106 on on ADP fnp-6284 113 107 , , PUNCT fnp-6284 113 108 canada canada PROPN fnp-6284 113 109 background background NOUN fnp-6284 113 110 : : PUNCT fnp-6284 113 111 diffuse diffuse ADJ fnp-6284 113 112 gliomas glioma NOUN fnp-6284 113 113 are be AUX fnp-6284 113 114 the the DET fnp-6284 113 115 most most ADV fnp-6284 113 116 common common ADJ fnp-6284 113 117 forms form NOUN fnp-6284 113 118 of of ADP fnp-6284 113 119 adult adult NOUN fnp-6284 113 120 brain brain NOUN fnp-6284 113 121 cancer cancer NOUN fnp-6284 113 122 , , PUNCT fnp-6284 113 123 but but CCONJ fnp-6284 113 124 exhibit exhibit VERB fnp-6284 113 125 substantial substantial ADJ fnp-6284 113 126 heterogeneity heterogeneity NOUN fnp-6284 113 127 in in ADP fnp-6284 113 128 outcomes outcome NOUN fnp-6284 113 129 . . PUNCT fnp-6284 114 1 while while SCONJ fnp-6284 114 2 much much ADJ fnp-6284 114 3 of of ADP fnp-6284 114 4 the the DET fnp-6284 114 5 clinical clinical ADJ fnp-6284 114 6 variability variability NOUN fnp-6284 114 7 has have AUX fnp-6284 114 8 recently recently ADV fnp-6284 114 9 been be AUX fnp-6284 114 10 objectively objectively ADV fnp-6284 114 11 resolved resolve VERB fnp-6284 114 12 by by ADP fnp-6284 114 13 molecular molecular ADJ fnp-6284 114 14 profiling profiling NOUN fnp-6284 114 15 and and CCONJ fnp-6284 114 16 subclassification subclassification NOUN fnp-6284 114 17 of of ADP fnp-6284 114 18 gliomas glioma NOUN fnp-6284 114 19 into into ADP fnp-6284 114 20 isocitrate isocitrate ADJ fnp-6284 114 21 dehydrogenase dehydrogenase NOUN fnp-6284 114 22 ( ( PUNCT fnp-6284 114 23 idh)-wildtype idh)-wildtype PROPN fnp-6284 114 24 ( ( PUNCT fnp-6284 114 25 glioblastoma glioblastoma NOUN fnp-6284 114 26 ) ) PUNCT fnp-6284 114 27 and and CCONJ fnp-6284 114 28 idh idh NOUN fnp-6284 114 29 - - PUNCT fnp-6284 114 30 mutant mutant NOUN fnp-6284 114 31 tumors tumor NOUN fnp-6284 114 32 , , PUNCT fnp-6284 114 33 the the DET fnp-6284 114 34 later later ADV fnp-6284 114 35 with with ADP fnp-6284 114 36 and and CCONJ fnp-6284 114 37 without without ADP fnp-6284 114 38 1p19q 1p19q ADJ fnp-6284 114 39 chromosomal chromosomal ADJ fnp-6284 114 40 codeletions codeletion NOUN fnp-6284 114 41 ( ( PUNCT fnp-6284 114 42 oligodendroglioma oligodendroglioma ADJ fnp-6284 114 43 , , PUNCT fnp-6284 114 44 astrocytoma astrocytoma NOUN fnp-6284 114 45 respectively respectively ADV fnp-6284 114 46 ) ) PUNCT fnp-6284 114 47 , , PUNCT fnp-6284 114 48 these these DET fnp-6284 114 49 subgroups subgroup NOUN fnp-6284 114 50 still still ADV fnp-6284 114 51 exhibit exhibit VERB fnp-6284 114 52 patient patient NOUN fnp-6284 114 53 - - PUNCT fnp-6284 114 54 level level NOUN fnp-6284 114 55 differences difference NOUN fnp-6284 114 56 in in ADP fnp-6284 114 57 progression progression NOUN fnp-6284 114 58 that that SCONJ fnp-6284 114 59 challenge challenge NOUN fnp-6284 114 60 precision precision NOUN fnp-6284 114 61 management management NOUN fnp-6284 114 62 and and CCONJ fnp-6284 114 63 care care NOUN fnp-6284 114 64 . . PUNCT fnp-6284 115 1 hypothesis hypothesis NOUN fnp-6284 115 2 : : PUNCT fnp-6284 115 3 we we PRON fnp-6284 115 4 hypothesized hypothesize VERB fnp-6284 115 5 that that SCONJ fnp-6284 115 6 integrating integrate VERB fnp-6284 115 7 artificial artificial ADJ fnp-6284 115 8 intelligence intelligence NOUN fnp-6284 115 9 - - PUNCT fnp-6284 115 10 derived derive VERB fnp-6284 115 11 tissue tissue NOUN fnp-6284 115 12 features feature NOUN fnp-6284 115 13 with with ADP fnp-6284 115 14 modern modern ADJ fnp-6284 115 15 molecular molecular ADJ fnp-6284 115 16 subgrouping subgrouping NOUN fnp-6284 115 17 may may AUX fnp-6284 115 18 resolve resolve VERB fnp-6284 115 19 further further ADJ fnp-6284 115 20 variation variation NOUN fnp-6284 115 21 of of ADP fnp-6284 115 22 outcome outcome NOUN fnp-6284 115 23 within within ADP fnp-6284 115 24 established establish VERB fnp-6284 115 25 glioma glioma NOUN fnp-6284 115 26 subtypes subtype NOUN fnp-6284 115 27 . . PUNCT fnp-6284 116 1 scientific scientific ADJ fnp-6284 116 2 approach approach NOUN fnp-6284 116 3 : : PUNCT fnp-6284 116 4 to to PART fnp-6284 116 5 explore explore VERB fnp-6284 116 6 this this DET fnp-6284 116 7 hypothesis hypothesis NOUN fnp-6284 116 8 , , PUNCT fnp-6284 116 9 we we PRON fnp-6284 116 10 retrieved retrieve VERB fnp-6284 116 11 the the DET fnp-6284 116 12 clinical clinical ADJ fnp-6284 116 13 cohort cohort NOUN fnp-6284 116 14 of of ADP fnp-6284 116 15 gliomas glioma NOUN fnp-6284 116 16 from from ADP fnp-6284 116 17 the the DET fnp-6284 116 18 cancer cancer NOUN fnp-6284 116 19 genome genome NOUN fnp-6284 116 20 atlas atlas PROPN fnp-6284 116 21 and and CCONJ fnp-6284 116 22 used use VERB fnp-6284 116 23 a a DET fnp-6284 116 24 publicly publicly ADV fnp-6284 116 25 available available ADJ fnp-6284 116 26 tool tool NOUN fnp-6284 116 27 we we PRON fnp-6284 116 28 previously previously ADV fnp-6284 116 29 developed develop VERB fnp-6284 116 30 , , PUNCT fnp-6284 116 31 pharaoh pharaoh NOUN fnp-6284 116 32 , , PUNCT fnp-6284 116 33 ( ( PUNCT fnp-6284 116 34 biorxiv biorxiv NOUN fnp-6284 116 35 2024 2024 NUM fnp-6284 116 36 ) ) PUNCT fnp-6284 116 37 , , PUNCT fnp-6284 116 38 to to PART fnp-6284 116 39 automatically automatically ADV fnp-6284 116 40 extract extract VERB fnp-6284 116 41 and and CCONJ fnp-6284 116 42 analyze analyze VERB fnp-6284 116 43 morphometric morphometric ADJ fnp-6284 116 44 features feature NOUN fnp-6284 116 45 of of ADP fnp-6284 116 46 all all DET fnp-6284 116 47 available available ADJ fnp-6284 116 48 cases case NOUN fnp-6284 116 49 ( ( PUNCT fnp-6284 116 50 tcga tcga NOUN fnp-6284 116 51 - - PUNCT fnp-6284 116 52 lgg lgg VERB fnp-6284 116 53 , , PUNCT fnp-6284 116 54 n n NOUN fnp-6284 116 55 = = SYM fnp-6284 116 56 722 722 NUM fnp-6284 116 57 ; ; PUNCT fnp-6284 116 58 tcga tcga PROPN fnp-6284 116 59 - - PUNCT fnp-6284 116 60 gbm gbm NOUN fnp-6284 116 61 , , PUNCT fnp-6284 116 62 n= n= ADJ fnp-6284 116 63 670 670 NUM fnp-6284 116 64 ) ) PUNCT fnp-6284 116 65 . . PUNCT fnp-6284 117 1 we we PRON fnp-6284 117 2 systematically systematically ADV fnp-6284 117 3 analyzed analyze VERB fnp-6284 117 4 160 160 NUM fnp-6284 117 5 different different ADJ fnp-6284 117 6 nuclear nuclear ADJ fnp-6284 117 7 features feature NOUN fnp-6284 117 8 and and CCONJ fnp-6284 117 9 correlated correlate VERB fnp-6284 117 10 the the DET fnp-6284 117 11 results result NOUN fnp-6284 117 12 with with ADP fnp-6284 117 13 accompanying accompany VERB fnp-6284 117 14 clinical clinical ADJ fnp-6284 117 15 pathological pathological ADJ fnp-6284 117 16 survival survival NOUN fnp-6284 117 17 data datum NOUN fnp-6284 117 18 in in ADP fnp-6284 117 19 3–5 3–5 NUM fnp-6284 117 20 relevant relevant ADJ fnp-6284 117 21 glioma glioma NOUN fnp-6284 117 22 subcohorts subcohort NOUN fnp-6284 117 23 . . PUNCT fnp-6284 118 1 results result NOUN fnp-6284 118 2 : : PUNCT fnp-6284 118 3 this this DET fnp-6284 118 4 systematic systematic ADJ fnp-6284 118 5 analysis analysis NOUN fnp-6284 118 6 revealed reveal VERB fnp-6284 118 7 morphometric morphometric ADJ fnp-6284 118 8 features feature NOUN fnp-6284 118 9 that that PRON fnp-6284 118 10 track track VERB fnp-6284 118 11 variations variation NOUN fnp-6284 118 12 in in ADP fnp-6284 118 13 nuclear nuclear ADJ fnp-6284 118 14 staining staining NOUN fnp-6284 118 15 and and CCONJ fnp-6284 118 16 cellularity cellularity NOUN fnp-6284 118 17 as as ADP fnp-6284 118 18 strong strong ADJ fnp-6284 118 19 predictors predictor NOUN fnp-6284 118 20 of of ADP fnp-6284 118 21 aggressive aggressive ADJ fnp-6284 118 22 disease disease NOUN fnp-6284 118 23 and and CCONJ fnp-6284 118 24 poorer poor ADJ fnp-6284 118 25 outcomes outcome NOUN fnp-6284 118 26 in in ADP fnp-6284 118 27 patients patient NOUN fnp-6284 118 28 with with ADP fnp-6284 118 29 grade grade NOUN fnp-6284 118 30 3 3 NUM fnp-6284 118 31 oligodendrogliomas oligodendroglioma NOUN fnp-6284 118 32 ; ; PUNCT fnp-6284 118 33 a a DET fnp-6284 118 34 notoriously notoriously ADV fnp-6284 118 35 clinical clinical ADJ fnp-6284 118 36 heterogenous heterogenous ADJ fnp-6284 118 37 glioma glioma NOUN fnp-6284 118 38 subgroup subgroup NOUN fnp-6284 118 39 . . PUNCT fnp-6284 119 1 importantly importantly ADV fnp-6284 119 2 , , PUNCT fnp-6284 119 3 this this DET fnp-6284 119 4 feature feature NOUN fnp-6284 119 5 extraction extraction NOUN fnp-6284 119 6 resource resource NOUN fnp-6284 119 7 is be AUX fnp-6284 119 8 publicly publicly ADV fnp-6284 119 9 available available ADJ fnp-6284 119 10 , , PUNCT fnp-6284 119 11 allowing allow VERB fnp-6284 119 12 these these DET fnp-6284 119 13 results result NOUN fnp-6284 119 14 to to PART fnp-6284 119 15 be be AUX fnp-6284 119 16 generalized generalize VERB fnp-6284 119 17 to to ADP fnp-6284 119 18 other other ADJ fnp-6284 119 19 cohorts cohort NOUN fnp-6284 119 20 . . PUNCT fnp-6284 120 1 conclusions conclusion NOUN fnp-6284 120 2 : : PUNCT fnp-6284 120 3 systematic systematic ADJ fnp-6284 120 4 characterization characterization NOUN fnp-6284 120 5 and and CCONJ fnp-6284 120 6 validation validation NOUN fnp-6284 120 7 of of ADP fnp-6284 120 8 morphometric morphometric ADJ fnp-6284 120 9 features feature NOUN fnp-6284 120 10 in in ADP fnp-6284 120 11 additional additional ADJ fnp-6284 120 12 cohorts cohort NOUN fnp-6284 120 13 and and CCONJ fnp-6284 120 14 clinical clinical ADJ fnp-6284 120 15 practice practice NOUN fnp-6284 120 16 may may AUX fnp-6284 120 17 support support VERB fnp-6284 120 18 the the DET fnp-6284 120 19 development development NOUN fnp-6284 120 20 of of ADP fnp-6284 120 21 more more ADV fnp-6284 120 22 advanced advanced ADJ fnp-6284 120 23 multimodal multimodal NOUN fnp-6284 120 24 biomarkers biomarker NOUN fnp-6284 120 25 that that PRON fnp-6284 120 26 can can AUX fnp-6284 120 27 better well ADV fnp-6284 120 28 predict predict VERB fnp-6284 120 29 outcome outcome NOUN fnp-6284 120 30 in in ADP fnp-6284 120 31 this this DET fnp-6284 120 32 aggressive aggressive ADJ fnp-6284 120 33 and and CCONJ fnp-6284 120 34 heterogeneous heterogeneous ADJ fnp-6284 120 35 disease disease NOUN fnp-6284 120 36 . . PUNCT fnp-6284 120 37     SPACE fnp-6284 121 1 abstract abstract ADJ fnp-6284 121 2 10 10 NUM fnp-6284 121 3 free free ADJ fnp-6284 121 4 neuropathol neuropathol NOUN fnp-6284 121 5 6:1:13 6:1:13 PROPN fnp-6284 121 6 a a DET fnp-6284 121 7 13 13 NUM fnp-6284 121 8 year year NOUN fnp-6284 121 9 review review NOUN fnp-6284 121 10 of of ADP fnp-6284 121 11 non non ADJ fnp-6284 121 12 - - ADJ fnp-6284 121 13 diffuse diffuse ADJ fnp-6284 121 14 large large ADJ fnp-6284 121 15 b b NOUN fnp-6284 121 16 cell cell NOUN fnp-6284 121 17 lymphomas lymphoma NOUN fnp-6284 121 18 of of ADP fnp-6284 121 19 the the DET fnp-6284 121 20 central central ADJ fnp-6284 121 21 nervous nervous ADJ fnp-6284 121 22 system system NOUN fnp-6284 121 23 at at ADP fnp-6284 121 24 a a DET fnp-6284 121 25 tertiary tertiary ADJ fnp-6284 121 26 hospital hospital NOUN fnp-6284 121 27 : : PUNCT fnp-6284 121 28 a a DET fnp-6284 121 29 case case NOUN fnp-6284 121 30 series series NOUN fnp-6284 121 31 study study VERB fnp-6284 121 32 niloofar niloofar PROPN fnp-6284 121 33 sina1 sina1 PROPN fnp-6284 121 34 , , PUNCT fnp-6284 121 35 chris chris PROPN fnp-6284 121 36 heyn2 heyn2 PROPN fnp-6284 121 37 , , PUNCT fnp-6284 121 38 zeina zeina PROPN fnp-6284 121 39 ghorab1 ghorab1 PROPN fnp-6284 121 40 , , PUNCT fnp-6284 121 41 julia julia PROPN fnp-6284 121 42 keith1 keith1 PROPN fnp-6284 121 43 laboratory laboratory NOUN fnp-6284 121 44 medicine medicine NOUN fnp-6284 121 45 and and CCONJ fnp-6284 121 46 molecular molecular ADJ fnp-6284 121 47 diagnostics diagnostic NOUN fnp-6284 121 48 , , PUNCT fnp-6284 121 49 sunnybrook sunnybrook PROPN fnp-6284 121 50 health health PROPN fnp-6284 121 51 sciences sciences PROPN fnp-6284 121 52 centre centre PROPN fnp-6284 121 53 , , PUNCT fnp-6284 121 54 laboratory laboratory NOUN fnp-6284 121 55 medicine medicine NOUN fnp-6284 121 56 and and CCONJ fnp-6284 121 57 pathobiology pathobiology NOUN fnp-6284 121 58 , , PUNCT fnp-6284 121 59 university university PROPN fnp-6284 121 60 of of ADP fnp-6284 121 61 toronto toronto PROPN fnp-6284 121 62 , , PUNCT fnp-6284 121 63 toronto toronto PROPN fnp-6284 121 64 , , PUNCT fnp-6284 121 65 on on ADP fnp-6284 121 66 , , PUNCT fnp-6284 121 67 canada canada PROPN fnp-6284 121 68 diagnostic diagnostic PROPN fnp-6284 121 69 imaging imaging PROPN fnp-6284 121 70 , , PUNCT fnp-6284 121 71 sunnybrook sunnybrook PROPN fnp-6284 121 72 health health PROPN fnp-6284 121 73 sciences sciences PROPN fnp-6284 121 74 centre centre PROPN fnp-6284 121 75 , , PUNCT fnp-6284 121 76 university university PROPN fnp-6284 121 77 of of ADP fnp-6284 121 78 toronto toronto PROPN fnp-6284 121 79 , , PUNCT fnp-6284 121 80 toronto toronto PROPN fnp-6284 121 81 , , PUNCT fnp-6284 121 82 on on ADP fnp-6284 121 83 , , PUNCT fnp-6284 121 84 canada canada PROPN fnp-6284 121 85 background background NOUN fnp-6284 121 86 : : PUNCT fnp-6284 121 87 non non ADJ fnp-6284 121 88 - - ADJ fnp-6284 121 89 diffuse diffuse ADJ fnp-6284 121 90 large large ADJ fnp-6284 121 91 b b NOUN fnp-6284 121 92 cell cell NOUN fnp-6284 121 93 lymphomas lymphoma NOUN fnp-6284 121 94 ( ( PUNCT fnp-6284 121 95 non non ADJ fnp-6284 121 96 - - ADJ fnp-6284 121 97 dlbcl dlbcl NOUN fnp-6284 121 98 ) ) PUNCT fnp-6284 121 99 of of ADP fnp-6284 121 100 the the DET fnp-6284 121 101 central central ADJ fnp-6284 121 102 nervous nervous ADJ fnp-6284 121 103 system system NOUN fnp-6284 121 104 ( ( PUNCT fnp-6284 121 105 cns cns NOUN fnp-6284 121 106 ) ) PUNCT fnp-6284 121 107 are be AUX fnp-6284 121 108 rare rare ADJ fnp-6284 121 109 . . PUNCT fnp-6284 122 1 the the DET fnp-6284 122 2 rarity rarity NOUN fnp-6284 122 3 of of ADP fnp-6284 122 4 such such ADJ fnp-6284 122 5 involvement involvement NOUN fnp-6284 122 6 poses pose VERB fnp-6284 122 7 a a DET fnp-6284 122 8 diagnostic diagnostic ADJ fnp-6284 122 9 challenge challenge NOUN fnp-6284 122 10 for for ADP fnp-6284 122 11 neuropathologists neuropathologist NOUN fnp-6284 122 12 and and CCONJ fnp-6284 122 13 increases increase VERB fnp-6284 122 14 the the DET fnp-6284 122 15 risk risk NOUN fnp-6284 122 16 of of ADP fnp-6284 122 17 misclassification misclassification NOUN fnp-6284 122 18 , , PUNCT fnp-6284 122 19 particularly particularly ADV fnp-6284 122 20 in in ADP fnp-6284 122 21 the the DET fnp-6284 122 22 absence absence NOUN fnp-6284 122 23 of of ADP fnp-6284 122 24 a a DET fnp-6284 122 25 preceding precede VERB fnp-6284 122 26 lymphoma lymphoma NOUN fnp-6284 122 27 diagnosis diagnosis NOUN fnp-6284 122 28 . . PUNCT fnp-6284 123 1 patients patient NOUN fnp-6284 123 2 and and CCONJ fnp-6284 123 3 methods method NOUN fnp-6284 123 4 : : PUNCT fnp-6284 123 5 in in ADP fnp-6284 123 6 this this DET fnp-6284 123 7 retrospective retrospective ADJ fnp-6284 123 8 study study NOUN fnp-6284 123 9 we we PRON fnp-6284 123 10 reviewed review VERB fnp-6284 123 11 the the DET fnp-6284 123 12 clinicopathologic clinicopathologic ADJ fnp-6284 123 13 and and CCONJ fnp-6284 123 14 imaging imaging NOUN fnp-6284 123 15 characteristics characteristic NOUN fnp-6284 123 16 of of ADP fnp-6284 123 17 seventeen seventeen NUM fnp-6284 123 18 cases case NOUN fnp-6284 123 19 of of ADP fnp-6284 123 20 non non NOUN fnp-6284 123 21 - - NOUN fnp-6284 123 22 dlbcl dlbcl NOUN fnp-6284 123 23 of of ADP fnp-6284 123 24 the the DET fnp-6284 123 25 cns cns NOUN fnp-6284 123 26 diagnosed diagnose VERB fnp-6284 123 27 from from ADP fnp-6284 123 28 2010 2010 NUM fnp-6284 123 29 to to ADP fnp-6284 123 30 2022 2022 NUM fnp-6284 123 31 by by ADP fnp-6284 123 32 neuropathology neuropathology NOUN fnp-6284 123 33 at at ADP fnp-6284 123 34 our our PRON fnp-6284 123 35 tertiary tertiary ADJ fnp-6284 123 36 hospital hospital NOUN fnp-6284 123 37 . . PUNCT fnp-6284 124 1 results result NOUN fnp-6284 124 2 : : PUNCT fnp-6284 124 3 the the DET fnp-6284 124 4 seventeen seventeen NUM fnp-6284 124 5 cases case NOUN fnp-6284 124 6 included include VERB fnp-6284 124 7 eight eight NUM fnp-6284 124 8 primary primary ADJ fnp-6284 124 9 lymphomas lymphoma NOUN fnp-6284 124 10 and and CCONJ fnp-6284 124 11 nine nine NUM fnp-6284 124 12 secondary secondary ADJ fnp-6284 124 13 lymphomas lymphoma NOUN fnp-6284 124 14 of of ADP fnp-6284 124 15 the the DET fnp-6284 124 16 cns cns NOUN fnp-6284 124 17 , , PUNCT fnp-6284 124 18 fifteen fifteen NUM fnp-6284 124 19 neurosurgical neurosurgical ADJ fnp-6284 124 20 cases case NOUN fnp-6284 124 21 and and CCONJ fnp-6284 124 22 two two NUM fnp-6284 124 23 autopsies autopsy NOUN fnp-6284 124 24 . . PUNCT fnp-6284 125 1 the the DET fnp-6284 125 2 tumours tumour NOUN fnp-6284 125 3 were be AUX fnp-6284 125 4 extra extra ADJ fnp-6284 125 5 - - ADJ fnp-6284 125 6 axial axial ADJ fnp-6284 125 7 in in ADP fnp-6284 125 8 nine nine NUM fnp-6284 125 9 and and CCONJ fnp-6284 125 10 intra intra ADJ fnp-6284 125 11 - - ADJ fnp-6284 125 12 parenchymal parenchymal ADJ fnp-6284 125 13 in in ADP fnp-6284 125 14 eight eight NUM fnp-6284 125 15 cases case NOUN fnp-6284 125 16 , , PUNCT fnp-6284 125 17 thirteen thirteen NUM fnp-6284 125 18 cases case NOUN fnp-6284 125 19 were be AUX fnp-6284 125 20 b b PRON fnp-6284 125 21 cell cell NOUN fnp-6284 125 22 origin origin NOUN fnp-6284 125 23 ( ( PUNCT fnp-6284 125 24 including include VERB fnp-6284 125 25 nine nine NUM fnp-6284 125 26 small small ADJ fnp-6284 125 27 mature mature ADJ fnp-6284 125 28 b b NOUN fnp-6284 125 29 cell cell NOUN fnp-6284 125 30 lymphomas lymphoma NOUN fnp-6284 125 31 , , PUNCT fnp-6284 125 32 three three NUM fnp-6284 125 33 large large ADJ fnp-6284 125 34 b b NOUN fnp-6284 125 35 cell cell NOUN fnp-6284 125 36 lymphomas lymphoma NOUN fnp-6284 125 37 and and CCONJ fnp-6284 125 38 one one NUM fnp-6284 125 39 pleomorphic pleomorphic ADJ fnp-6284 125 40 posttransplant posttransplant ADJ fnp-6284 125 41 lymphoproliferative lymphoproliferative ADJ fnp-6284 125 42 disorder disorder NOUN fnp-6284 125 43 ) ) PUNCT fnp-6284 125 44 and and CCONJ fnp-6284 125 45 four four NUM fnp-6284 125 46 cases case NOUN fnp-6284 125 47 were be AUX fnp-6284 125 48 t t NOUN fnp-6284 125 49 cell cell NOUN fnp-6284 125 50 origin origin NOUN fnp-6284 125 51 ( ( PUNCT fnp-6284 125 52 including include VERB fnp-6284 125 53 two two NUM fnp-6284 125 54 peripheral peripheral ADJ fnp-6284 125 55 t t NOUN fnp-6284 125 56 cell cell NOUN fnp-6284 125 57 lymphoma lymphoma NOUN fnp-6284 125 58 not not PART fnp-6284 125 59 otherwise otherwise ADV fnp-6284 125 60 specified specify VERB fnp-6284 125 61 , , PUNCT fnp-6284 125 62 one one NUM fnp-6284 125 63 anaplastic anaplastic ADJ fnp-6284 125 64 t t NOUN fnp-6284 125 65 cell cell NOUN fnp-6284 125 66 lymphoma lymphoma NOUN fnp-6284 125 67 alk alk VERB fnp-6284 125 68 negative negative ADJ fnp-6284 125 69 and and CCONJ fnp-6284 125 70 one one NUM fnp-6284 125 71 case case NOUN fnp-6284 125 72 of of ADP fnp-6284 125 73 disseminated disseminate VERB fnp-6284 125 74 mycosis mycosis NOUN fnp-6284 125 75 fungoides fungoide NOUN fnp-6284 125 76 ) ) PUNCT fnp-6284 125 77 . . PUNCT fnp-6284 126 1 four four NUM fnp-6284 126 2 distinct distinct ADJ fnp-6284 126 3 radiographic radiographic ADJ fnp-6284 126 4 patterns pattern NOUN fnp-6284 126 5 were be AUX fnp-6284 126 6 appreciated appreciate VERB fnp-6284 126 7 on on ADP fnp-6284 126 8 central central ADJ fnp-6284 126 9 imaging imaging NOUN fnp-6284 126 10 review review NOUN fnp-6284 126 11 . . PUNCT fnp-6284 127 1 conclusion conclusion NOUN fnp-6284 127 2 : : PUNCT fnp-6284 127 3 our our PRON fnp-6284 127 4 study study NOUN fnp-6284 127 5 highlights highlight VERB fnp-6284 127 6 the the DET fnp-6284 127 7 heterogeneity heterogeneity NOUN fnp-6284 127 8 of of ADP fnp-6284 127 9 non non ADJ fnp-6284 127 10 - - ADJ fnp-6284 127 11 dlbcl dlbcl ADJ fnp-6284 127 12 lymphomas lymphoma NOUN fnp-6284 127 13 of of ADP fnp-6284 127 14 cns cns PROPN fnp-6284 127 15 . . PUNCT fnp-6284 128 1 this this PRON fnp-6284 128 2 associated associate VERB fnp-6284 128 3 with with ADP fnp-6284 128 4 their their PRON fnp-6284 128 5 rarity rarity NOUN fnp-6284 128 6 and and CCONJ fnp-6284 128 7 variable variable ADJ fnp-6284 128 8 atypical atypical ADJ fnp-6284 128 9 features feature NOUN fnp-6284 128 10 increases increase VERB fnp-6284 128 11 the the DET fnp-6284 128 12 risk risk NOUN fnp-6284 128 13 of of ADP fnp-6284 128 14 misdiagnosis misdiagnosis NOUN fnp-6284 128 15 . . PUNCT fnp-6284 129 1 reports report NOUN fnp-6284 129 2 such such ADJ fnp-6284 129 3 as as ADP fnp-6284 129 4 this this DET fnp-6284 129 5 foster foster ADJ fnp-6284 129 6 consensus consensus NOUN fnp-6284 129 7 of of ADP fnp-6284 129 8 the the DET fnp-6284 129 9 diagnostic diagnostic ADJ fnp-6284 129 10 and and CCONJ fnp-6284 129 11 management management NOUN fnp-6284 129 12 strategies strategy NOUN fnp-6284 129 13 of of ADP fnp-6284 129 14 these these DET fnp-6284 129 15 rare rare ADJ fnp-6284 129 16 entities entity NOUN fnp-6284 129 17 . . PUNCT fnp-6284 129 18     SPACE fnp-6284 130 1 abstract abstract ADJ fnp-6284 130 2 11 11 NUM fnp-6284 130 3 free free ADJ fnp-6284 130 4 neuropathol neuropathol NOUN fnp-6284 130 5 6:1:14 6:1:14 NUM fnp-6284 130 6 cost cost NOUN fnp-6284 130 7 - - PUNCT fnp-6284 130 8 benefit benefit NOUN fnp-6284 130 9 analysis analysis NOUN fnp-6284 130 10 of of ADP fnp-6284 130 11 fluorescence fluorescence NOUN fnp-6284 130 12 in in ADP fnp-6284 130 13 situ situ ADJ fnp-6284 130 14 hybridization hybridization NOUN fnp-6284 130 15 testing testing NOUN fnp-6284 130 16 in in ADP fnp-6284 130 17 the the DET fnp-6284 130 18 diagnosis diagnosis NOUN fnp-6284 130 19 of of ADP fnp-6284 130 20 idh idh NOUN fnp-6284 130 21 - - PUNCT fnp-6284 130 22 mutant mutant NOUN fnp-6284 130 23 1p/19q 1p/19q NOUN fnp-6284 130 24 - - PUNCT fnp-6284 130 25 codeleted codelete VERB fnp-6284 130 26 oligodendrogliomas oligodendroglioma NOUN fnp-6284 130 27 jacob jacob PROPN fnp-6284 130 28 a. a. PROPN fnp-6284 130 29 houpt1 houpt1 PROPN fnp-6284 130 30 , , PUNCT fnp-6284 130 31 robert robert PROPN fnp-6284 130 32 r. r. PROPN fnp-6284 130 33 hammond1 hammond1 PROPN fnp-6284 130 34 department department PROPN fnp-6284 130 35 of of ADP fnp-6284 130 36 pathology pathology PROPN fnp-6284 130 37 and and CCONJ fnp-6284 130 38 laboratory laboratory NOUN fnp-6284 130 39 medicine medicine NOUN fnp-6284 130 40 , , PUNCT fnp-6284 130 41 london london PROPN fnp-6284 130 42 health health PROPN fnp-6284 130 43 sciences sciences PROPN fnp-6284 130 44 centre centre PROPN fnp-6284 130 45 , , PUNCT fnp-6284 130 46 london london PROPN fnp-6284 130 47 , , PUNCT fnp-6284 130 48 on on ADP fnp-6284 130 49 , , PUNCT fnp-6284 130 50 canada canada PROPN fnp-6284 130 51 fluorescence fluorescence NOUN fnp-6284 130 52 in in ADP fnp-6284 130 53 situ situ ADJ fnp-6284 130 54 hybridization hybridization NOUN fnp-6284 130 55 ( ( PUNCT fnp-6284 130 56 fish fish NOUN fnp-6284 130 57 ) ) PUNCT fnp-6284 130 58 testing testing NOUN fnp-6284 130 59 has have AUX fnp-6284 130 60 long long ADV fnp-6284 130 61 served serve VERB fnp-6284 130 62 as as ADP fnp-6284 130 63 a a DET fnp-6284 130 64 diagnostic diagnostic ADJ fnp-6284 130 65 cornerstone cornerstone NOUN fnp-6284 130 66 in in ADP fnp-6284 130 67 confirming confirm VERB fnp-6284 130 68 codeletion codeletion NOUN fnp-6284 130 69 of of ADP fnp-6284 130 70 the the DET fnp-6284 130 71 1p 1p NUM fnp-6284 130 72 and and CCONJ fnp-6284 130 73 19q 19q NUM fnp-6284 130 74 chromosome chromosome NOUN fnp-6284 130 75 arms arm NOUN fnp-6284 130 76 in in ADP fnp-6284 130 77 idh idh NOUN fnp-6284 130 78 - - PUNCT fnp-6284 130 79 mutant mutant NOUN fnp-6284 130 80 1p/19q 1p/19q NOUN fnp-6284 130 81 - - PUNCT fnp-6284 130 82 codeleted codelete VERB fnp-6284 130 83 oligodendrogliomas oligodendroglioma NOUN fnp-6284 130 84 ; ; PUNCT fnp-6284 130 85 a a DET fnp-6284 130 86 test test NOUN fnp-6284 130 87 necessary necessary ADJ fnp-6284 130 88 to to PART fnp-6284 130 89 distinguish distinguish VERB fnp-6284 130 90 the the DET fnp-6284 130 91 entity entity NOUN fnp-6284 130 92 from from ADP fnp-6284 130 93 other other ADJ fnp-6284 130 94 diffuse diffuse ADJ fnp-6284 130 95 adult adult NOUN fnp-6284 130 96 - - PUNCT fnp-6284 130 97 type type NOUN fnp-6284 130 98 gliomas glioma NOUN fnp-6284 130 99 . . PUNCT fnp-6284 131 1 however however ADV fnp-6284 131 2 , , PUNCT fnp-6284 131 3 fish fish NOUN fnp-6284 131 4 is be AUX fnp-6284 131 5 both both CCONJ fnp-6284 131 6 costly costly ADJ fnp-6284 131 7 and and CCONJ fnp-6284 131 8 time time NOUN fnp-6284 131 9 - - PUNCT fnp-6284 131 10 consuming consume VERB fnp-6284 131 11 relative relative NOUN fnp-6284 131 12 to to ADP fnp-6284 131 13 other other ADJ fnp-6284 131 14 ancillary ancillary ADJ fnp-6284 131 15 tests test NOUN fnp-6284 131 16 such such ADJ fnp-6284 131 17 as as ADP fnp-6284 131 18 next next ADJ fnp-6284 131 19 generation generation NOUN fnp-6284 131 20 sequencing sequence VERB fnp-6284 131 21 ( ( PUNCT fnp-6284 131 22 ngs ng NOUN fnp-6284 131 23 ) ) PUNCT fnp-6284 131 24 , , PUNCT fnp-6284 131 25 requiring require VERB fnp-6284 131 26 expensive expensive ADJ fnp-6284 131 27 fluorescent fluorescent ADJ fnp-6284 131 28 probes probe NOUN fnp-6284 131 29 , , PUNCT fnp-6284 131 30 specialized specialized ADJ fnp-6284 131 31 microscopy microscopy NOUN fnp-6284 131 32 suites suite NOUN fnp-6284 131 33 , , PUNCT fnp-6284 131 34 and and CCONJ fnp-6284 131 35 manual manual ADJ fnp-6284 131 36 evaluation evaluation NOUN fnp-6284 131 37 / / SYM fnp-6284 131 38 counting counting NOUN fnp-6284 131 39 by by ADP fnp-6284 131 40 dedicated dedicated ADJ fnp-6284 131 41 medical medical ADJ fnp-6284 131 42 lab lab NOUN fnp-6284 131 43 technologists technologist NOUN fnp-6284 131 44 ( ( PUNCT fnp-6284 131 45 mlts mlt NOUN fnp-6284 131 46 ) ) PUNCT fnp-6284 131 47 . . PUNCT fnp-6284 132 1 as as SCONJ fnp-6284 132 2 institutions institution NOUN fnp-6284 132 3 such such ADJ fnp-6284 132 4 as as ADP fnp-6284 132 5 london london PROPN fnp-6284 132 6 health health PROPN fnp-6284 132 7 sciences sciences PROPN fnp-6284 132 8 centre centre PROPN fnp-6284 132 9 ( ( PUNCT fnp-6284 132 10 lhsc lhsc PROPN fnp-6284 132 11 ) ) PUNCT fnp-6284 132 12 proceed proceed VERB fnp-6284 132 13 to to PART fnp-6284 132 14 validate validate VERB fnp-6284 132 15 ngs ng NOUN fnp-6284 132 16 copy copy VERB fnp-6284 132 17 number number NOUN fnp-6284 132 18 variation variation NOUN fnp-6284 132 19 assessment assessment NOUN fnp-6284 132 20 in in ADP fnp-6284 132 21 place place NOUN fnp-6284 132 22 of of ADP fnp-6284 132 23 direct direct ADJ fnp-6284 132 24 fish fish NOUN fnp-6284 132 25 testing testing NOUN fnp-6284 132 26 for for ADP fnp-6284 132 27 the the DET fnp-6284 132 28 evaluation evaluation NOUN fnp-6284 132 29 of of ADP fnp-6284 132 30 1p/19q 1p/19q NOUN fnp-6284 132 31 - - PUNCT fnp-6284 132 32 codeletion codeletion NOUN fnp-6284 132 33 in in ADP fnp-6284 132 34 gliomas glioma NOUN fnp-6284 132 35 , , PUNCT fnp-6284 132 36 we we PRON fnp-6284 132 37 reviewed review VERB fnp-6284 132 38 all all DET fnp-6284 132 39 1p/19q 1p/19q NOUN fnp-6284 132 40 cytogenetic cytogenetic ADJ fnp-6284 132 41 test test NOUN fnp-6284 132 42 results result NOUN fnp-6284 132 43 at at ADP fnp-6284 132 44 our our PRON fnp-6284 132 45 institution institution NOUN fnp-6284 132 46 to to PART fnp-6284 132 47 better well ADV fnp-6284 132 48 contextualize contextualize VERB fnp-6284 132 49 fish fish NOUN fnp-6284 132 50 testing testing NOUN fnp-6284 132 51 in in ADP fnp-6284 132 52 terms term NOUN fnp-6284 132 53 of of ADP fnp-6284 132 54 cost cost NOUN fnp-6284 132 55 - - PUNCT fnp-6284 132 56 benefit benefit NOUN fnp-6284 132 57 ratio ratio NOUN fnp-6284 132 58 ( ( PUNCT fnp-6284 132 59 cbr cbr NOUN fnp-6284 132 60 ) ) PUNCT fnp-6284 132 61 . . PUNCT fnp-6284 133 1 from from ADP fnp-6284 133 2 2010 2010 NUM fnp-6284 133 3 to to ADP fnp-6284 133 4 2024 2024 NUM fnp-6284 133 5 , , PUNCT fnp-6284 133 6 700 700 NUM fnp-6284 133 7 cytogenetics cytogenetic NOUN fnp-6284 133 8 cases case NOUN fnp-6284 133 9 reporting report VERB fnp-6284 133 10 1p/19q 1p/19q NOUN fnp-6284 133 11 - - PUNCT fnp-6284 133 12 codeletion codeletion NOUN fnp-6284 133 13 were be AUX fnp-6284 133 14 retrieved retrieve VERB fnp-6284 133 15 . . PUNCT fnp-6284 134 1 of of ADP fnp-6284 134 2 these these PRON fnp-6284 134 3 , , PUNCT fnp-6284 134 4 171 171 NUM fnp-6284 134 5 were be AUX fnp-6284 134 6 positive positive ADJ fnp-6284 134 7 for for ADP fnp-6284 134 8 codeletion codeletion NOUN fnp-6284 134 9 of of ADP fnp-6284 134 10 1p/19q 1p/19q NOUN fnp-6284 134 11 ( ( PUNCT fnp-6284 134 12 24.4 24.4 NUM fnp-6284 134 13     SPACE fnp-6284 134 14 % % NOUN fnp-6284 134 15 ) ) PUNCT fnp-6284 134 16 . . PUNCT fnp-6284 135 1 repeat repeat PROPN fnp-6284 135 2 testing testing NOUN fnp-6284 135 3 was be AUX fnp-6284 135 4 requested request VERB fnp-6284 135 5 in in ADP fnp-6284 135 6 25 25 NUM fnp-6284 135 7 cases case NOUN fnp-6284 135 8 ( ( PUNCT fnp-6284 135 9 3.6 3.6 NUM fnp-6284 135 10     SPACE fnp-6284 135 11 % % NOUN fnp-6284 135 12 ) ) PUNCT fnp-6284 135 13 due due ADP fnp-6284 135 14 to to ADP fnp-6284 135 15 borderline borderline NOUN fnp-6284 135 16 results result NOUN fnp-6284 135 17 and/or and/or CCONJ fnp-6284 135 18 increased increase VERB fnp-6284 135 19 clinical clinical ADJ fnp-6284 135 20 suspicion suspicion NOUN fnp-6284 135 21 , , PUNCT fnp-6284 135 22 yielding yield VERB fnp-6284 135 23 a a DET fnp-6284 135 24 different different ADJ fnp-6284 135 25 diagnosis diagnosis NOUN fnp-6284 135 26 in in ADP fnp-6284 135 27 at at ADV fnp-6284 135 28 least least ADJ fnp-6284 135 29 3 3 NUM fnp-6284 135 30 cases case NOUN fnp-6284 135 31 . . PUNCT fnp-6284 136 1 conservative conservative ADJ fnp-6284 136 2 estimates estimate NOUN fnp-6284 136 3 of of ADP fnp-6284 136 4 the the DET fnp-6284 136 5 per per NOUN fnp-6284 136 6 case case NOUN fnp-6284 136 7 cost cost NOUN fnp-6284 136 8 of of ADP fnp-6284 136 9 fish fish NOUN fnp-6284 136 10 testing testing NOUN fnp-6284 136 11 ( ( PUNCT fnp-6284 136 12 including include VERB fnp-6284 136 13 facility facility NOUN fnp-6284 136 14 / / SYM fnp-6284 136 15 equipment equipment NOUN fnp-6284 136 16 , , PUNCT fnp-6284 136 17 reagents reagent NOUN fnp-6284 136 18 , , PUNCT fnp-6284 136 19 and and CCONJ fnp-6284 136 20 mlt mlt AUX fnp-6284 136 21 labour labour NOUN fnp-6284 136 22 / / SYM fnp-6284 136 23 time time NOUN fnp-6284 136 24 ) ) PUNCT fnp-6284 136 25 total total NOUN fnp-6284 136 26 at at ADV fnp-6284 136 27 least least ADV fnp-6284 136 28 $ $ SYM fnp-6284 136 29 1400 1400 NUM fnp-6284 136 30 cad cad NOUN fnp-6284 136 31 . . PUNCT fnp-6284 137 1 while while SCONJ fnp-6284 137 2 its its PRON fnp-6284 137 3 cbr cbr NOUN fnp-6284 137 4 is be AUX fnp-6284 137 5 comparable comparable ADJ fnp-6284 137 6 to to ADP fnp-6284 137 7 other other ADJ fnp-6284 137 8 oncological oncological ADJ fnp-6284 137 9 investigations investigation NOUN fnp-6284 137 10 and and CCONJ fnp-6284 137 11 can can AUX fnp-6284 137 12 be be AUX fnp-6284 137 13 less less ADV fnp-6284 137 14 expensive expensive ADJ fnp-6284 137 15 than than ADP fnp-6284 137 16 ngs ng NOUN fnp-6284 137 17 on on ADP fnp-6284 137 18 a a DET fnp-6284 137 19 per per ADP fnp-6284 137 20 test test NOUN fnp-6284 137 21 basis basis NOUN fnp-6284 137 22 , , PUNCT fnp-6284 137 23 ngs ng NOUN fnp-6284 137 24 is be AUX fnp-6284 137 25 often often ADV fnp-6284 137 26 ordered order VERB fnp-6284 137 27 in in ADP fnp-6284 137 28 conjunction conjunction NOUN fnp-6284 137 29 to to PART fnp-6284 137 30 facilitate facilitate VERB fnp-6284 137 31 confirmation confirmation NOUN fnp-6284 137 32 of of ADP fnp-6284 137 33 idh idh NOUN fnp-6284 137 34 mutations mutation NOUN fnp-6284 137 35 and and CCONJ fnp-6284 137 36 therefore therefore ADV fnp-6284 137 37 is be AUX fnp-6284 137 38 poised poise VERB fnp-6284 137 39 to to PART fnp-6284 137 40 save save VERB fnp-6284 137 41 considerable considerable ADJ fnp-6284 137 42 time time NOUN fnp-6284 137 43 and and CCONJ fnp-6284 137 44 cost cost VERB fnp-6284 137 45 if if SCONJ fnp-6284 137 46 all all DET fnp-6284 137 47 but but CCONJ fnp-6284 137 48 borderline borderline ADJ fnp-6284 137 49 cases case NOUN fnp-6284 137 50 of of ADP fnp-6284 137 51 1p/19q 1p/19q NOUN fnp-6284 137 52 - - PUNCT fnp-6284 137 53 codeletion codeletion NOUN fnp-6284 137 54 can can AUX fnp-6284 137 55 be be AUX fnp-6284 137 56 elucidated elucidate VERB fnp-6284 137 57 without without ADP fnp-6284 137 58 undertaking undertake VERB fnp-6284 137 59 cytogenetic cytogenetic ADJ fnp-6284 137 60 evaluation evaluation NOUN fnp-6284 137 61 via via ADP fnp-6284 137 62 fish fish NOUN fnp-6284 137 63 . . PUNCT fnp-6284 137 64     SPACE fnp-6284 138 1 abstract abstract ADJ fnp-6284 138 2 12 12 NUM fnp-6284 138 3 free free ADJ fnp-6284 138 4 neuropathol neuropathol NOUN fnp-6284 138 5 6:1:15 6:1:15 NUM fnp-6284 138 6 infant infant NOUN fnp-6284 138 7 - - PUNCT fnp-6284 138 8 type type NOUN fnp-6284 138 9 hemispheric hemispheric ADJ fnp-6284 138 10 glioma glioma NOUN fnp-6284 138 11 is be AUX fnp-6284 138 12 mostly mostly ADV fnp-6284 138 13 relatively relatively ADV fnp-6284 138 14 well well ADV fnp-6284 138 15 - - PUNCT fnp-6284 138 16 demarcated demarcate VERB fnp-6284 138 17 tumor tumor NOUN fnp-6284 138 18 and and CCONJ fnp-6284 138 19 not not PART fnp-6284 138 20 diffusely diffusely ADV fnp-6284 138 21 infiltrative infiltrative ADJ fnp-6284 138 22 murad murad NOUN fnp-6284 138 23 alturkustani1 alturkustani1 PROPN fnp-6284 139 1 department department PROPN fnp-6284 139 2 of of ADP fnp-6284 139 3 pathology pathology PROPN fnp-6284 139 4 , , PUNCT fnp-6284 139 5 king king PROPN fnp-6284 139 6 abdulaziz abdulaziz PROPN fnp-6284 139 7 university university PROPN fnp-6284 139 8 , , PUNCT fnp-6284 139 9 jeddah jeddah PROPN fnp-6284 139 10 , , PUNCT fnp-6284 139 11 saudi saudi PROPN fnp-6284 139 12 arabia arabia PROPN fnp-6284 139 13 background background NOUN fnp-6284 139 14 : : PUNCT fnp-6284 139 15     SPACE fnp-6284 139 16 ihg ihg PROPN fnp-6284 139 17 has have AUX fnp-6284 139 18 been be AUX fnp-6284 139 19 identified identify VERB fnp-6284 139 20 as as ADP fnp-6284 139 21 a a DET fnp-6284 139 22 distinct distinct ADJ fnp-6284 139 23 entity entity NOUN fnp-6284 139 24 with with ADP fnp-6284 139 25 unique unique ADJ fnp-6284 139 26 methylation methylation NOUN fnp-6284 139 27 patterns pattern NOUN fnp-6284 139 28 and and CCONJ fnp-6284 139 29 gene gene NOUN fnp-6284 139 30 fusions fusion NOUN fnp-6284 139 31 , , PUNCT fnp-6284 139 32 presenting present VERB fnp-6284 139 33 a a DET fnp-6284 139 34 better well ADJ fnp-6284 139 35 prognosis prognosis NOUN fnp-6284 139 36 than than ADP fnp-6284 139 37 other other ADJ fnp-6284 139 38 pediatric pediatric ADJ fnp-6284 139 39 high high ADJ fnp-6284 139 40 - - PUNCT fnp-6284 139 41 grade grade NOUN fnp-6284 139 42 gliomas glioma NOUN fnp-6284 139 43 . . PUNCT fnp-6284 140 1 the the DET fnp-6284 140 2 current current NOUN fnp-6284 140 3 who who PRON fnp-6284 140 4 classification classification NOUN fnp-6284 140 5 presents present VERB fnp-6284 140 6 discrepancies discrepancy NOUN fnp-6284 140 7 regarding regard VERB fnp-6284 140 8 the the DET fnp-6284 140 9 tumor tumor NOUN fnp-6284 140 10 's 's PART fnp-6284 140 11 circumscription circumscription NOUN fnp-6284 140 12 , , PUNCT fnp-6284 140 13 necessitating necessitate VERB fnp-6284 140 14 further further ADJ fnp-6284 140 15 investigation investigation NOUN fnp-6284 140 16 . . PUNCT fnp-6284 141 1 methods method NOUN fnp-6284 141 2 : : PUNCT fnp-6284 141 3     SPACE fnp-6284 141 4 the the DET fnp-6284 141 5 children child NOUN fnp-6284 141 6 's 's PART fnp-6284 141 7 brain brain NOUN fnp-6284 141 8 tumor tumor NOUN fnp-6284 141 9 network network NOUN fnp-6284 141 10 dataset dataset NOUN fnp-6284 141 11 of of ADP fnp-6284 141 12 1029 1029 NUM fnp-6284 141 13 samples sample NOUN fnp-6284 141 14 was be AUX fnp-6284 141 15 accessed access VERB fnp-6284 141 16 , , PUNCT fnp-6284 141 17 selecting select VERB fnp-6284 141 18 tumors tumor NOUN fnp-6284 141 19 from from ADP fnp-6284 141 20 patients patient NOUN fnp-6284 141 21 aged age VERB fnp-6284 141 22 0–4 0–4 NUM fnp-6284 141 23 years year NOUN fnp-6284 141 24 , , PUNCT fnp-6284 141 25 resulting result VERB fnp-6284 141 26 in in ADP fnp-6284 141 27 191 191 NUM fnp-6284 141 28 gliomas glioma NOUN fnp-6284 141 29 , , PUNCT fnp-6284 141 30 glioneuronal glioneuronal ADJ fnp-6284 141 31 tumors tumor NOUN fnp-6284 141 32 , , PUNCT fnp-6284 141 33 and and CCONJ fnp-6284 141 34 ependymomas ependymomas PROPN fnp-6284 141 35 . . PUNCT fnp-6284 142 1 methylation methylation NOUN fnp-6284 142 2 profiles profile NOUN fnp-6284 142 3 were be AUX fnp-6284 142 4 analyzed analyze VERB fnp-6284 142 5 using use VERB fnp-6284 142 6 the the DET fnp-6284 142 7 heidelberg heidelberg NOUN fnp-6284 142 8 v12.5 v12.5 NOUN fnp-6284 142 9 and and CCONJ fnp-6284 142 10 v12.8 v12.8 NOUN fnp-6284 142 11 classifiers classifier NOUN fnp-6284 142 12 . . PUNCT fnp-6284 143 1 cases case NOUN fnp-6284 143 2 were be AUX fnp-6284 143 3 selected select VERB fnp-6284 143 4 based base VERB fnp-6284 143 5 on on ADP fnp-6284 143 6 diagnoses diagnosis NOUN fnp-6284 143 7 of of ADP fnp-6284 143 8 ihg ihg PROPN fnp-6284 143 9 , , PUNCT fnp-6284 143 10 desmoplastic desmoplastic ADJ fnp-6284 143 11 infantile infantile ADJ fnp-6284 143 12 astrocytoma astrocytoma NOUN fnp-6284 143 13     SPACE fnp-6284 143 14 / / SYM fnp-6284 143 15     SPACE fnp-6284 143 16 ganglioglioma ganglioglioma PROPN fnp-6284 143 17 ( ( PUNCT fnp-6284 143 18 dia dia PROPN fnp-6284 143 19 / / SYM fnp-6284 143 20 g g PROPN fnp-6284 143 21 ) ) PUNCT fnp-6284 143 22 , , PUNCT fnp-6284 143 23 or or CCONJ fnp-6284 143 24 high high ADJ fnp-6284 143 25 - - PUNCT fnp-6284 143 26 grade grade NOUN fnp-6284 143 27 gliomas glioma NOUN fnp-6284 143 28 with with ADP fnp-6284 143 29 available available ADJ fnp-6284 143 30 methylation methylation NOUN fnp-6284 143 31 class class NOUN fnp-6284 143 32 . . PUNCT fnp-6284 144 1 morphological morphological ADJ fnp-6284 144 2 assessments assessment NOUN fnp-6284 144 3 focused focus VERB fnp-6284 144 4 on on ADP fnp-6284 144 5 tumor tumor NOUN fnp-6284 144 6 circumscription circumscription NOUN fnp-6284 144 7 , , PUNCT fnp-6284 144 8 low low ADJ fnp-6284 144 9 - - PUNCT fnp-6284 144 10 grade grade NOUN fnp-6284 144 11 areas area NOUN fnp-6284 144 12 , , PUNCT fnp-6284 144 13 glial glial ADJ fnp-6284 144 14 differentiation differentiation NOUN fnp-6284 144 15 , , PUNCT fnp-6284 144 16 and and CCONJ fnp-6284 144 17 high high ADJ fnp-6284 144 18 - - PUNCT fnp-6284 144 19 grade grade NOUN fnp-6284 144 20 features feature NOUN fnp-6284 144 21 . . PUNCT fnp-6284 145 1 results result NOUN fnp-6284 145 2 : : PUNCT fnp-6284 145 3     SPACE fnp-6284 145 4 the the DET fnp-6284 145 5 final final ADJ fnp-6284 145 6 cohort cohort NOUN fnp-6284 145 7 included include VERB fnp-6284 145 8 12 12 NUM fnp-6284 145 9 cases case NOUN fnp-6284 145 10 : : PUNCT fnp-6284 145 11 4 4 NUM fnp-6284 145 12 with with ADP fnp-6284 145 13 an an DET fnp-6284 145 14 initial initial ADJ fnp-6284 145 15 diagnosis diagnosis NOUN fnp-6284 145 16 of of ADP fnp-6284 145 17 dia dia PROPN fnp-6284 145 18 / / SYM fnp-6284 145 19 g g PROPN fnp-6284 145 20 , , PUNCT fnp-6284 145 21 and and CCONJ fnp-6284 145 22 8 8 NUM fnp-6284 145 23 with with ADP fnp-6284 145 24 an an DET fnp-6284 145 25 initial initial ADJ fnp-6284 145 26 diagnosis diagnosis NOUN fnp-6284 145 27 of of ADP fnp-6284 145 28 high high ADJ fnp-6284 145 29 - - PUNCT fnp-6284 145 30 grade grade NOUN fnp-6284 145 31 astrocytoma astrocytoma NOUN fnp-6284 145 32 ( ( PUNCT fnp-6284 145 33 6 6 NUM fnp-6284 145 34 diagnosed diagnose VERB fnp-6284 145 35 as as ADP fnp-6284 145 36 ihg ihg PROPN fnp-6284 145 37 ) ) PUNCT fnp-6284 145 38 . . PUNCT fnp-6284 146 1 all all DET fnp-6284 146 2 ihg ihg PROPN fnp-6284 146 3 cases case NOUN fnp-6284 146 4 were be AUX fnp-6284 146 5 infantile infantile ADJ fnp-6284 146 6 tumors tumor NOUN fnp-6284 146 7 , , PUNCT fnp-6284 146 8 while while SCONJ fnp-6284 146 9 dia dia PROPN fnp-6284 146 10 / / SYM fnp-6284 146 11 g g PROPN fnp-6284 146 12 cases case NOUN fnp-6284 146 13 were be AUX fnp-6284 146 14 in in ADP fnp-6284 146 15 older old ADJ fnp-6284 146 16 children child NOUN fnp-6284 146 17 . . PUNCT fnp-6284 147 1 both both DET fnp-6284 147 2 ihg ihg PROPN fnp-6284 147 3 and and CCONJ fnp-6284 147 4 dia dia PROPN fnp-6284 147 5 / / SYM fnp-6284 147 6 g g PROPN fnp-6284 147 7 were be AUX fnp-6284 147 8 well well ADV fnp-6284 147 9 - - PUNCT fnp-6284 147 10 circumscribed circumscribe VERB fnp-6284 147 11 , , PUNCT fnp-6284 147 12 whereas whereas SCONJ fnp-6284 147 13 the the DET fnp-6284 147 14 case case NOUN fnp-6284 147 15 with with ADP fnp-6284 147 16 diffuse diffuse NOUN fnp-6284 147 17 infiltration infiltration NOUN fnp-6284 147 18 was be AUX fnp-6284 147 19 classified classify VERB fnp-6284 147 20 as as ADP fnp-6284 147 21 diffuse diffuse PROPN fnp-6284 147 22 pediatric pediatric ADJ fnp-6284 147 23 high high ADJ fnp-6284 147 24 - - PUNCT fnp-6284 147 25 grade grade NOUN fnp-6284 147 26 glioma glioma NOUN fnp-6284 147 27 . . PUNCT fnp-6284 148 1 the the DET fnp-6284 148 2 4 4 NUM fnp-6284 148 3 dia dia PROPN fnp-6284 148 4 / / SYM fnp-6284 148 5 g g PROPN fnp-6284 148 6 cases case NOUN fnp-6284 148 7 were be AUX fnp-6284 148 8 heterogeneous heterogeneous ADJ fnp-6284 148 9 , , PUNCT fnp-6284 148 10 with with ADP fnp-6284 148 11 only only ADV fnp-6284 148 12 one one NUM fnp-6284 148 13 showing show VERB fnp-6284 148 14 the the DET fnp-6284 148 15 methylation methylation NOUN fnp-6284 148 16 profile profile NOUN fnp-6284 148 17 of of ADP fnp-6284 148 18 dig dig NOUN fnp-6284 148 19 . . PUNCT fnp-6284 149 1 one one NUM fnp-6284 149 2 dia dia PROPN fnp-6284 149 3 / / SYM fnp-6284 149 4 g g PROPN fnp-6284 149 5 case case NOUN fnp-6284 149 6 was be AUX fnp-6284 149 7 reclassified reclassify VERB fnp-6284 149 8 as as ADP fnp-6284 149 9 ihg ihg PROPN fnp-6284 149 10 . . PUNCT fnp-6284 150 1 the the DET fnp-6284 150 2 remaining remain VERB fnp-6284 150 3 six six NUM fnp-6284 150 4 ihg ihg PROPN fnp-6284 150 5 cases case NOUN fnp-6284 150 6 were be AUX fnp-6284 150 7 initially initially ADV fnp-6284 150 8 diagnosed diagnose VERB fnp-6284 150 9 as as ADP fnp-6284 150 10 high high ADJ fnp-6284 150 11 - - PUNCT fnp-6284 150 12 grade grade NOUN fnp-6284 150 13 astrocytoma astrocytoma NOUN fnp-6284 150 14 . . PUNCT fnp-6284 151 1 conclusion conclusion NOUN fnp-6284 151 2 : : PUNCT fnp-6284 151 3     SPACE fnp-6284 151 4 ihg ihg PROPN fnp-6284 151 5 is be AUX fnp-6284 151 6 predominantly predominantly ADV fnp-6284 151 7 a a DET fnp-6284 151 8 well well ADV fnp-6284 151 9 - - PUNCT fnp-6284 151 10 circumscribed circumscribe VERB fnp-6284 151 11 tumor tumor NOUN fnp-6284 151 12 , , PUNCT fnp-6284 151 13 contrasting contrast VERB fnp-6284 151 14 with with ADP fnp-6284 151 15 the the DET fnp-6284 151 16 diffuse diffuse PROPN fnp-6284 151 17 infiltration infiltration NOUN fnp-6284 151 18 characteristic characteristic NOUN fnp-6284 151 19 of of ADP fnp-6284 151 20 other other ADJ fnp-6284 151 21 pediatric pediatric ADJ fnp-6284 151 22 high high ADJ fnp-6284 151 23 - - PUNCT fnp-6284 151 24 grade grade NOUN fnp-6284 151 25 gliomas glioma NOUN fnp-6284 151 26 . . PUNCT fnp-6284 152 1 recognizing recognize VERB fnp-6284 152 2 these these DET fnp-6284 152 3 histological histological ADJ fnp-6284 152 4 features feature NOUN fnp-6284 152 5 , , PUNCT fnp-6284 152 6 along along ADP fnp-6284 152 7 with with ADP fnp-6284 152 8 molecular molecular ADJ fnp-6284 152 9 profiling profiling NOUN fnp-6284 152 10 , , PUNCT fnp-6284 152 11 is be AUX fnp-6284 152 12 crucial crucial ADJ fnp-6284 152 13 for for ADP fnp-6284 152 14 accurate accurate ADJ fnp-6284 152 15 diagnosis diagnosis NOUN fnp-6284 152 16 and and CCONJ fnp-6284 152 17 management management NOUN fnp-6284 152 18 . . PUNCT fnp-6284 152 19     SPACE fnp-6284 153 1 abstract abstract ADJ fnp-6284 153 2 13 13 NUM fnp-6284 153 3 free free ADJ fnp-6284 153 4 neuropathol neuropathol NOUN fnp-6284 153 5 6:1:16 6:1:16 NUM fnp-6284 153 6 features feature NOUN fnp-6284 153 7 of of ADP fnp-6284 153 8 central central ADJ fnp-6284 153 9 nervous nervous ADJ fnp-6284 153 10 system system NOUN fnp-6284 153 11 metastases metastasis NOUN fnp-6284 153 12 by by ADP fnp-6284 153 13 neoplasms neoplasm NOUN fnp-6284 153 14 of of ADP fnp-6284 153 15 gynecological gynecological ADJ fnp-6284 153 16 origin origin NOUN fnp-6284 153 17 mimi mimi PROPN fnp-6284 153 18 zhang1 zhang1 PROPN fnp-6284 153 19 , , PUNCT fnp-6284 153 20 jacob jacob PROPN fnp-6284 153 21 a. a. PROPN fnp-6284 153 22 houpt1 houpt1 PROPN fnp-6284 153 23 , , PUNCT fnp-6284 153 24 lee lee PROPN fnp-6284 153 25 - - PUNCT fnp-6284 153 26 cyn cyn PROPN fnp-6284 153 27 ang1 ang1 PROPN fnp-6284 153 28 department department PROPN fnp-6284 153 29 of of ADP fnp-6284 153 30 pathology pathology PROPN fnp-6284 153 31 and and CCONJ fnp-6284 153 32 laboratory laboratory NOUN fnp-6284 153 33 medicine medicine NOUN fnp-6284 153 34 , , PUNCT fnp-6284 153 35 london london PROPN fnp-6284 153 36 health health PROPN fnp-6284 153 37 sciences sciences PROPN fnp-6284 153 38 centre centre PROPN fnp-6284 153 39 , , PUNCT fnp-6284 153 40 london london PROPN fnp-6284 153 41 , , PUNCT fnp-6284 153 42 on on ADP fnp-6284 153 43 , , PUNCT fnp-6284 153 44 canada canada PROPN fnp-6284 153 45 central central ADJ fnp-6284 153 46 nervous nervous ADJ fnp-6284 153 47 system system NOUN fnp-6284 153 48 involvement involvement NOUN fnp-6284 153 49 by by ADP fnp-6284 153 50 metastasis metastasis NOUN fnp-6284 153 51 from from ADP fnp-6284 153 52 extra extra ADJ fnp-6284 153 53 - - ADJ fnp-6284 153 54 axial axial ADJ fnp-6284 153 55 malignancies malignancy NOUN fnp-6284 153 56 represent represent VERB fnp-6284 153 57 the the DET fnp-6284 153 58 most most ADV fnp-6284 153 59 common common ADJ fnp-6284 153 60 cns cns NOUN fnp-6284 153 61 neoplasms neoplasm NOUN fnp-6284 153 62 in in ADP fnp-6284 153 63 adults adult NOUN fnp-6284 153 64 , , PUNCT fnp-6284 153 65 with with ADP fnp-6284 153 66 primary primary ADJ fnp-6284 153 67 lung lung NOUN fnp-6284 153 68 , , PUNCT fnp-6284 153 69 breast breast NOUN fnp-6284 153 70 , , PUNCT fnp-6284 153 71 renal renal ADJ fnp-6284 153 72 , , PUNCT fnp-6284 153 73 and and CCONJ fnp-6284 153 74 colorectal colorectal ADJ fnp-6284 153 75 carcinomas carcinoma NOUN fnp-6284 153 76 and and CCONJ fnp-6284 153 77 cutaneous cutaneous ADJ fnp-6284 153 78 melanomas melanoma NOUN fnp-6284 153 79 representing represent VERB fnp-6284 153 80 the the DET fnp-6284 153 81 majority majority NOUN fnp-6284 153 82 of of ADP fnp-6284 153 83 such such ADJ fnp-6284 153 84 . . PUNCT fnp-6284 154 1 cns cns NOUN fnp-6284 154 2 metastases metastasis NOUN fnp-6284 154 3 of of ADP fnp-6284 154 4 gynecological gynecological ADJ fnp-6284 154 5 origin origin NOUN fnp-6284 154 6 are be AUX fnp-6284 154 7 relatively relatively ADV fnp-6284 154 8 rare rare ADJ fnp-6284 154 9 – – PUNCT fnp-6284 154 10 making make VERB fnp-6284 154 11 up up ADP fnp-6284 154 12 no no DET fnp-6284 154 13 more more ADJ fnp-6284 154 14 than than ADP fnp-6284 154 15 3 3 NUM fnp-6284 154 16     SPACE fnp-6284 154 17 % % NOUN fnp-6284 154 18 of of ADP fnp-6284 154 19 cases case NOUN fnp-6284 154 20 of of ADP fnp-6284 154 21 cns cns NOUN fnp-6284 154 22 metastases metastasis NOUN fnp-6284 154 23 and and CCONJ fnp-6284 154 24 occurring occur VERB fnp-6284 154 25 in in ADP fnp-6284 154 26 as as ADV fnp-6284 154 27 few few ADJ fnp-6284 154 28 as as ADP fnp-6284 154 29 0.6 0.6 NUM fnp-6284 154 30     SPACE fnp-6284 154 31 % % NOUN fnp-6284 154 32 of of ADP fnp-6284 154 33 gynecological gynecological ADJ fnp-6284 154 34 cancer cancer NOUN fnp-6284 154 35 patients patient NOUN fnp-6284 154 36 . . PUNCT fnp-6284 155 1 all all DET fnp-6284 155 2 previous previous ADJ fnp-6284 155 3 cases case NOUN fnp-6284 155 4 of of ADP fnp-6284 155 5 cns cns NOUN fnp-6284 155 6 metastases metastasis NOUN fnp-6284 155 7 at at ADP fnp-6284 155 8 london london PROPN fnp-6284 155 9 health health PROPN fnp-6284 155 10 sciences sciences PROPN fnp-6284 155 11 centre centre PROPN fnp-6284 155 12 ( ( PUNCT fnp-6284 155 13 lhsc lhsc PROPN fnp-6284 155 14 ) ) PUNCT fnp-6284 155 15 were be AUX fnp-6284 155 16 screened screen VERB fnp-6284 155 17 for for ADP fnp-6284 155 18 keywords keyword NOUN fnp-6284 155 19 related relate VERB fnp-6284 155 20 to to ADP fnp-6284 155 21 ovarian ovarian ADJ fnp-6284 155 22 , , PUNCT fnp-6284 155 23 endometrial endometrial ADJ fnp-6284 155 24 , , PUNCT fnp-6284 155 25 and and CCONJ fnp-6284 155 26 cervical cervical ADJ fnp-6284 155 27 origin origin NOUN fnp-6284 155 28 . . PUNCT fnp-6284 156 1 cases case NOUN fnp-6284 156 2 where where SCONJ fnp-6284 156 3 another another DET fnp-6284 156 4 possible possible ADJ fnp-6284 156 5 primary primary NOUN fnp-6284 156 6 was be AUX fnp-6284 156 7 speculated speculate VERB fnp-6284 156 8 to to PART fnp-6284 156 9 be be AUX fnp-6284 156 10 more more ADV fnp-6284 156 11 likely likely ADJ fnp-6284 156 12 or or CCONJ fnp-6284 156 13 cases case NOUN fnp-6284 156 14 lacking lack VERB fnp-6284 156 15 a a DET fnp-6284 156 16 known know VERB fnp-6284 156 17 or or CCONJ fnp-6284 156 18 suspected suspect VERB fnp-6284 156 19 primary primary ADJ fnp-6284 156 20 gynecological gynecological ADJ fnp-6284 156 21 malignancy malignancy NOUN fnp-6284 156 22 ( ( PUNCT fnp-6284 156 23 based base VERB fnp-6284 156 24 on on ADP fnp-6284 156 25 previous previous ADJ fnp-6284 156 26 pathology pathology NOUN fnp-6284 156 27 or or CCONJ fnp-6284 156 28 imaging imaging NOUN fnp-6284 156 29 investigations investigation NOUN fnp-6284 156 30 ) ) PUNCT fnp-6284 156 31 were be AUX fnp-6284 156 32 excluded exclude VERB fnp-6284 156 33 . . PUNCT fnp-6284 157 1 this this PRON fnp-6284 157 2 yielded yield VERB fnp-6284 157 3 6 6 NUM fnp-6284 157 4 and and CCONJ fnp-6284 157 5 15 15 NUM fnp-6284 157 6 cases case NOUN fnp-6284 157 7 of of ADP fnp-6284 157 8 metastases metastasis NOUN fnp-6284 157 9 compatible compatible ADJ fnp-6284 157 10 with with ADP fnp-6284 157 11 ovarian ovarian ADJ fnp-6284 157 12 and and CCONJ fnp-6284 157 13 endometrial endometrial ADJ fnp-6284 157 14 primaries primary NOUN fnp-6284 157 15 , , PUNCT fnp-6284 157 16 respectively respectively ADV fnp-6284 157 17 . . PUNCT fnp-6284 158 1 of of ADP fnp-6284 158 2 the the DET fnp-6284 158 3 6 6 NUM fnp-6284 158 4 ovarian ovarian ADJ fnp-6284 158 5 cases case NOUN fnp-6284 158 6 , , PUNCT fnp-6284 158 7 3 3 NUM fnp-6284 158 8 ( ( PUNCT fnp-6284 158 9 50 50 NUM fnp-6284 158 10     SPACE fnp-6284 158 11 % % NOUN fnp-6284 158 12 ) ) PUNCT fnp-6284 158 13 were be AUX fnp-6284 158 14 associated associate VERB fnp-6284 158 15 with with ADP fnp-6284 158 16 poorly poorly ADV fnp-6284 158 17 - - PUNCT fnp-6284 158 18 differentiated differentiate VERB fnp-6284 158 19 ovarian ovarian ADJ fnp-6284 158 20 adenocarcinoma adenocarcinoma NOUN fnp-6284 158 21 primaries primary NOUN fnp-6284 158 22 , , PUNCT fnp-6284 158 23 2 2 NUM fnp-6284 158 24 with with ADP fnp-6284 158 25 high high ADJ fnp-6284 158 26 - - PUNCT fnp-6284 158 27 grade grade NOUN fnp-6284 158 28 serous serous ADJ fnp-6284 158 29 ovarian ovarian ADJ fnp-6284 158 30 adenocarcinomas adenocarcinoma NOUN fnp-6284 158 31 , , PUNCT fnp-6284 158 32 and and CCONJ fnp-6284 158 33 a a DET fnp-6284 158 34 single single ADJ fnp-6284 158 35 case case NOUN fnp-6284 158 36 of of ADP fnp-6284 158 37 mixed mixed ADJ fnp-6284 158 38 clear clear ADJ fnp-6284 158 39 - - PUNCT fnp-6284 158 40 cell cell NOUN fnp-6284 158 41 and and CCONJ fnp-6284 158 42 serous serous ADJ fnp-6284 158 43 ovarian ovarian ADJ fnp-6284 158 44 adenocarcinoma adenocarcinoma NOUN fnp-6284 158 45 in in ADP fnp-6284 158 46 which which PRON fnp-6284 158 47 the the DET fnp-6284 158 48 serous serous ADJ fnp-6284 158 49 component component NOUN fnp-6284 158 50 predominated predominate VERB fnp-6284 158 51 in in ADP fnp-6284 158 52 the the DET fnp-6284 158 53 metastasis metastasis NOUN fnp-6284 158 54 . . PUNCT fnp-6284 159 1 within within ADP fnp-6284 159 2 the the DET fnp-6284 159 3 15 15 NUM fnp-6284 159 4 cases case NOUN fnp-6284 159 5 of of ADP fnp-6284 159 6 uterine uterine ADJ fnp-6284 159 7 primaries primary NOUN fnp-6284 159 8 , , PUNCT fnp-6284 159 9 4 4 NUM fnp-6284 159 10 were be AUX fnp-6284 159 11 associated associate VERB fnp-6284 159 12 with with ADP fnp-6284 159 13 endometrioid endometrioid PROPN fnp-6284 159 14 , , PUNCT fnp-6284 159 15 1 1 NUM fnp-6284 159 16 with with ADP fnp-6284 159 17 serous serous ADJ fnp-6284 159 18 , , PUNCT fnp-6284 159 19 1 1 NUM fnp-6284 159 20 with with ADP fnp-6284 159 21 mixed mixed ADJ fnp-6284 159 22 , , PUNCT fnp-6284 159 23 and and CCONJ fnp-6284 159 24 4 4 NUM fnp-6284 159 25 with with ADP fnp-6284 159 26 poorly poorly ADV fnp-6284 159 27 - - PUNCT fnp-6284 159 28 differentiated differentiate VERB fnp-6284 159 29 adenocarcinomas adenocarcinoma NOUN fnp-6284 159 30 . . PUNCT fnp-6284 160 1 the the DET fnp-6284 160 2 remaining remain VERB fnp-6284 160 3 cases case NOUN fnp-6284 160 4 included include VERB fnp-6284 160 5 a a DET fnp-6284 160 6 leiomyosarcoma leiomyosarcoma NOUN fnp-6284 160 7 and and CCONJ fnp-6284 160 8 4 4 NUM fnp-6284 160 9 carcinosarcomas carcinosarcoma NOUN fnp-6284 160 10 , , PUNCT fnp-6284 160 11 the the DET fnp-6284 160 12 latter latter NOUN fnp-6284 160 13 of of ADP fnp-6284 160 14 which which PRON fnp-6284 160 15 featured feature VERB fnp-6284 160 16 a a DET fnp-6284 160 17 predominating predominate VERB fnp-6284 160 18 epithelial epithelial ADJ fnp-6284 160 19 component component NOUN fnp-6284 160 20 in in ADP fnp-6284 160 21 2 2 NUM fnp-6284 160 22 cases case NOUN fnp-6284 160 23 , , PUNCT fnp-6284 160 24 dual dual ADJ fnp-6284 160 25 components component NOUN fnp-6284 160 26 in in ADP fnp-6284 160 27 a a DET fnp-6284 160 28 single single ADJ fnp-6284 160 29 case case NOUN fnp-6284 160 30 , , PUNCT fnp-6284 160 31 and and CCONJ fnp-6284 160 32 a a DET fnp-6284 160 33 rhabdomyosarcoma rhabdomyosarcoma NOUN fnp-6284 160 34 component component NOUN fnp-6284 160 35 in in ADP fnp-6284 160 36 the the DET fnp-6284 160 37 final final ADJ fnp-6284 160 38 case case NOUN fnp-6284 160 39 . . PUNCT fnp-6284 161 1 relative relative ADJ fnp-6284 161 2 to to ADP fnp-6284 161 3 other other ADJ fnp-6284 161 4 primary primary ADJ fnp-6284 161 5 malignancies malignancy NOUN fnp-6284 161 6 , , PUNCT fnp-6284 161 7 poorly poorly ADV fnp-6284 161 8 - - PUNCT fnp-6284 161 9 differentiated differentiate VERB fnp-6284 161 10 primary primary ADJ fnp-6284 161 11 carcinomas carcinoma NOUN fnp-6284 161 12 are be AUX fnp-6284 161 13 over over ADV fnp-6284 161 14 - - PUNCT fnp-6284 161 15 represented represent VERB fnp-6284 161 16 in in ADP fnp-6284 161 17 metastases metastasis NOUN fnp-6284 161 18 from from ADP fnp-6284 161 19 gynecological gynecological ADJ fnp-6284 161 20 origin origin NOUN fnp-6284 161 21 ( ( PUNCT fnp-6284 161 22 both both CCONJ fnp-6284 161 23 in in ADP fnp-6284 161 24 ovarian ovarian ADJ fnp-6284 161 25 and and CCONJ fnp-6284 161 26 non non ADJ fnp-6284 161 27 - - ADJ fnp-6284 161 28 ovarian ovarian ADJ fnp-6284 161 29 cases case NOUN fnp-6284 161 30 ) ) PUNCT fnp-6284 161 31 . . PUNCT fnp-6284 162 1 copyright copyright NOUN fnp-6284 162 2 : : PUNCT fnp-6284 162 3 © © PROPN fnp-6284 162 4 2025 2025 NUM fnp-6284 162 5 the the DET fnp-6284 162 6 author(s author(s NOUN fnp-6284 162 7 ) ) PUNCT fnp-6284 162 8 . . PUNCT fnp-6284 163 1 this this PRON fnp-6284 163 2 is be AUX fnp-6284 163 3 an an DET fnp-6284 163 4 open open ADJ fnp-6284 163 5 access access NOUN fnp-6284 163 6 article article NOUN fnp-6284 163 7 distributed distribute VERB fnp-6284 163 8 under under ADP fnp-6284 163 9 the the DET fnp-6284 163 10 terms term NOUN fnp-6284 163 11 of of ADP fnp-6284 163 12 the the DET fnp-6284 163 13 creative creative ADJ fnp-6284 163 14 commons common NOUN fnp-6284 163 15 attribution attribution NOUN fnp-6284 163 16 4.0 4.0 NUM fnp-6284 163 17 international international ADJ fnp-6284 163 18 license license NOUN fnp-6284 163 19 ( ( PUNCT fnp-6284 163 20 https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/ PROPN fnp-6284 163 21 ) ) PUNCT fnp-6284 163 22 , , PUNCT fnp-6284 163 23 which which PRON fnp-6284 163 24 permits permit VERB fnp-6284 163 25 unrestricted unrestricted ADJ fnp-6284 163 26 use use NOUN fnp-6284 163 27 , , PUNCT fnp-6284 163 28 distribution distribution NOUN fnp-6284 163 29 , , PUNCT fnp-6284 163 30 and and CCONJ fnp-6284 163 31 reproduction reproduction NOUN fnp-6284 163 32 in in ADP fnp-6284 163 33 any any DET fnp-6284 163 34 medium medium NOUN fnp-6284 163 35 , , PUNCT fnp-6284 163 36 provided provide VERB fnp-6284 163 37 the the DET fnp-6284 163 38 original original ADJ fnp-6284 163 39 author author NOUN fnp-6284 163 40 and and CCONJ fnp-6284 163 41 source source NOUN fnp-6284 163 42 are be AUX fnp-6284 163 43 credited credit VERB fnp-6284 163 44 , , PUNCT fnp-6284 163 45 a a DET fnp-6284 163 46 link link NOUN fnp-6284 163 47 to to ADP fnp-6284 163 48 the the DET fnp-6284 163 49 creative creative ADJ fnp-6284 163 50 commons common NOUN fnp-6284 163 51 license license NOUN fnp-6284 163 52 is be AUX fnp-6284 163 53 provided provide VERB fnp-6284 163 54 , , PUNCT fnp-6284 163 55 and and CCONJ fnp-6284 163 56 any any DET fnp-6284 163 57 changes change NOUN fnp-6284 163 58 are be AUX fnp-6284 163 59 indicated indicate VERB fnp-6284 163 60 . . PUNCT fnp-6284 164 1 the the DET fnp-6284 164 2 creative creative ADJ fnp-6284 164 3 commons common NOUN fnp-6284 164 4 public public ADJ fnp-6284 164 5 domain domain NOUN fnp-6284 164 6 dedication dedication NOUN fnp-6284 164 7 waiver waiver NOUN fnp-6284 164 8 ( ( PUNCT fnp-6284 164 9 https://creativecommons.org/publicdomain/zero/1.0/ https://creativecommons.org/publicdomain/zero/1.0/ PROPN fnp-6284 164 10 ) ) PUNCT fnp-6284 164 11 applies apply VERB fnp-6284 164 12 to to ADP fnp-6284 164 13 the the DET fnp-6284 164 14 data datum NOUN fnp-6284 164 15 made make VERB fnp-6284 164 16 available available ADJ fnp-6284 164 17 in in ADP fnp-6284 164 18 this this DET fnp-6284 164 19 article article NOUN fnp-6284 164 20 , , PUNCT fnp-6284 164 21 unless unless SCONJ fnp-6284 164 22 otherwise otherwise ADV fnp-6284 164 23 stated state VERB fnp-6284 164 24 . . PUNCT