id	sid	tid	token	lemma	pos
fnp-6316	1	1	neurooncology	neurooncology	NOUN
fnp-6316	1	2	:	:	PUNCT
fnp-6316	1	3	2025	2025	NUM
fnp-6316	1	4	update	update	NOUN
fnp-6316	1	5	free	free	ADJ
fnp-6316	1	6	neuropathology	neuropathology	NOUN
fnp-6316	1	7	6:10	6:10	NUM
fnp-6316	1	8	(	(	PUNCT
fnp-6316	1	9	2025	2025	NUM
fnp-6316	1	10	)	)	PUNCT
fnp-6316	1	11	michel	michel	PROPN
fnp-6316	1	12	mittelbronn	mittelbronn	PROPN
fnp-6316	1	13	doi	doi	PROPN
fnp-6316	1	14	:	:	PUNCT
fnp-6316	1	15	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	1	16	page	page	NOUN
fnp-6316	1	17	1	1	NUM
fnp-6316	1	18	of	of	ADP
fnp-6316	1	19	19	19	NUM
fnp-6316	1	20	copyright	copyright	NOUN
fnp-6316	1	21	:	:	PUNCT
fnp-6316	1	22	©	©	PROPN
fnp-6316	1	23	2025	2025	NUM
fnp-6316	1	24	the	the	DET
fnp-6316	1	25	author(s	author(s	NOUN
fnp-6316	1	26	)	)	PUNCT
fnp-6316	1	27	.	.	PUNCT
fnp-6316	2	1	this	this	PRON
fnp-6316	2	2	is	be	AUX
fnp-6316	2	3	an	an	DET
fnp-6316	2	4	open	open	ADJ
fnp-6316	2	5	access	access	NOUN
fnp-6316	2	6	article	article	NOUN
fnp-6316	2	7	distributed	distribute	VERB
fnp-6316	2	8	under	under	ADP
fnp-6316	2	9	the	the	DET
fnp-6316	2	10	terms	term	NOUN
fnp-6316	2	11	of	of	ADP
fnp-6316	2	12	the	the	DET
fnp-6316	2	13	creative	creative	ADJ
fnp-6316	2	14	commons	common	NOUN
fnp-6316	2	15	attribution	attribution	NOUN
fnp-6316	2	16	4.0	4.0	NUM
fnp-6316	2	17	international	international	ADJ
fnp-6316	2	18	license	license	NOUN
fnp-6316	2	19	(	(	PUNCT
fnp-6316	2	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-6316	2	21	)	)	PUNCT
fnp-6316	2	22	,	,	PUNCT
fnp-6316	2	23	which	which	PRON
fnp-6316	2	24	permits	permit	VERB
fnp-6316	2	25	unrestricted	unrestricted	ADJ
fnp-6316	2	26	use	use	NOUN
fnp-6316	2	27	,	,	PUNCT
fnp-6316	2	28	distribution	distribution	NOUN
fnp-6316	2	29	,	,	PUNCT
fnp-6316	2	30	and	and	CCONJ
fnp-6316	2	31	reproduction	reproduction	NOUN
fnp-6316	2	32	in	in	ADP
fnp-6316	2	33	any	any	DET
fnp-6316	2	34	medium	medium	NOUN
fnp-6316	2	35	,	,	PUNCT
fnp-6316	2	36	provided	provide	VERB
fnp-6316	2	37	the	the	DET
fnp-6316	2	38	original	original	ADJ
fnp-6316	2	39	author	author	NOUN
fnp-6316	2	40	and	and	CCONJ
fnp-6316	2	41	source	source	NOUN
fnp-6316	2	42	are	be	AUX
fnp-6316	2	43	credited	credit	VERB
fnp-6316	2	44	,	,	PUNCT
fnp-6316	2	45	a	a	DET
fnp-6316	2	46	link	link	NOUN
fnp-6316	2	47	to	to	ADP
fnp-6316	2	48	the	the	DET
fnp-6316	2	49	creative	creative	ADJ
fnp-6316	2	50	commons	common	NOUN
fnp-6316	2	51	license	license	NOUN
fnp-6316	2	52	is	be	AUX
fnp-6316	2	53	provided	provide	VERB
fnp-6316	2	54	,	,	PUNCT
fnp-6316	2	55	and	and	CCONJ
fnp-6316	2	56	any	any	DET
fnp-6316	2	57	changes	change	NOUN
fnp-6316	2	58	are	be	AUX
fnp-6316	2	59	indicated	indicate	VERB
fnp-6316	2	60	.	.	PUNCT
fnp-6316	3	1	the	the	DET
fnp-6316	3	2	creative	creative	ADJ
fnp-6316	3	3	commons	common	NOUN
fnp-6316	3	4	public	public	ADJ
fnp-6316	3	5	domain	domain	NOUN
fnp-6316	3	6	dedication	dedication	NOUN
fnp-6316	3	7	waiver	waiver	NOUN
fnp-6316	3	8	(	(	PUNCT
fnp-6316	3	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-6316	3	10	)	)	PUNCT
fnp-6316	3	11	applies	apply	VERB
fnp-6316	3	12	to	to	ADP
fnp-6316	3	13	the	the	DET
fnp-6316	3	14	data	datum	NOUN
fnp-6316	3	15	made	make	VERB
fnp-6316	3	16	available	available	ADJ
fnp-6316	3	17	in	in	ADP
fnp-6316	3	18	this	this	DET
fnp-6316	3	19	article	article	NOUN
fnp-6316	3	20	,	,	PUNCT
fnp-6316	3	21	unless	unless	SCONJ
fnp-6316	3	22	otherwise	otherwise	ADV
fnp-6316	3	23	stated	state	VERB
fnp-6316	3	24	.	.	PUNCT
fnp-6316	4	1	neurooncology	neurooncology	NOUN
fnp-6316	4	2	:	:	PUNCT
fnp-6316	4	3	2025	2025	NUM
fnp-6316	4	4	update	update	NOUN
fnp-6316	4	5	michel	michel	PROPN
fnp-6316	4	6	mittelbronn1,2	mittelbronn1,2	PROPN
fnp-6316	4	7	1	1	NUM
fnp-6316	4	8	department	department	NOUN
fnp-6316	4	9	of	of	ADP
fnp-6316	4	10	life	life	NOUN
fnp-6316	4	11	sciences	science	NOUN
fnp-6316	4	12	and	and	CCONJ
fnp-6316	4	13	medicine	medicine	NOUN
fnp-6316	4	14	(	(	PUNCT
fnp-6316	4	15	dlsm	dlsm	PROPN
fnp-6316	4	16	)	)	PUNCT
fnp-6316	4	17	;	;	PUNCT
fnp-6316	4	18	university	university	NOUN
fnp-6316	4	19	of	of	ADP
fnp-6316	4	20	luxembourg	luxembourg	PROPN
fnp-6316	4	21	;	;	PUNCT
fnp-6316	4	22	esch	esch	PROPN
fnp-6316	4	23	sur	sur	PROPN
fnp-6316	4	24	alzette	alzette	PROPN
fnp-6316	4	25	,	,	PUNCT
fnp-6316	4	26	luxembourg	luxembourg	PROPN
fnp-6316	4	27	2	2	NUM
fnp-6316	4	28	faculty	faculty	NOUN
fnp-6316	4	29	of	of	ADP
fnp-6316	4	30	science	science	NOUN
fnp-6316	4	31	,	,	PUNCT
fnp-6316	4	32	technology	technology	NOUN
fnp-6316	4	33	and	and	CCONJ
fnp-6316	4	34	medicine	medicine	NOUN
fnp-6316	4	35	(	(	PUNCT
fnp-6316	4	36	fstm	fstm	PROPN
fnp-6316	4	37	)	)	PUNCT
fnp-6316	4	38	,	,	PUNCT
fnp-6316	4	39	university	university	NOUN
fnp-6316	4	40	of	of	ADP
fnp-6316	4	41	luxembourg	luxembourg	PROPN
fnp-6316	4	42	,	,	PUNCT
fnp-6316	4	43	esch	esch	PROPN
fnp-6316	4	44	-	-	PUNCT
fnp-6316	4	45	sur	sur	PROPN
fnp-6316	4	46	-	-	PUNCT
fnp-6316	4	47	alzette	alzette	NOUN
fnp-6316	4	48	,	,	PUNCT
fnp-6316	4	49	luxembourg	luxembourg	PROPN
fnp-6316	4	50	corresponding	corresponding	ADJ
fnp-6316	4	51	author	author	NOUN
fnp-6316	4	52	:	:	PUNCT
fnp-6316	4	53	michel	michel	PROPN
fnp-6316	4	54	mittelbronn	mittelbronn	PROPN
fnp-6316	4	55	·	·	PUNCT
fnp-6316	4	56	department	department	PROPN
fnp-6316	4	57	of	of	ADP
fnp-6316	4	58	life	life	NOUN
fnp-6316	4	59	sciences	sciences	PROPN
fnp-6316	4	60	and	and	CCONJ
fnp-6316	4	61	medicine	medicine	NOUN
fnp-6316	4	62	(	(	PUNCT
fnp-6316	4	63	dlsm	dlsm	PROPN
fnp-6316	4	64	)	)	PUNCT
fnp-6316	4	65	·	·	PUNCT
fnp-6316	4	66	university	university	NOUN
fnp-6316	4	67	of	of	ADP
fnp-6316	4	68	luxembourg	luxembourg	PROPN
fnp-6316	4	69	·	·	PUNCT
fnp-6316	4	70	6	6	NUM
fnp-6316	4	71	,	,	PUNCT
fnp-6316	4	72	avenue	avenue	PROPN
fnp-6316	4	73	du	du	NOUN
fnp-6316	4	74	swing	swing	NOUN
fnp-6316	4	75	·	·	PUNCT
fnp-6316	5	1	l-4367	l-4367	PROPN
fnp-6316	5	2	belvaux	belvaux	ADJ
fnp-6316	5	3	·	·	PUNCT
fnp-6316	5	4	luxembourg	luxembourg	PROPN
fnp-6316	5	5	·	·	PUNCT
fnp-6316	5	6	michel.mittelbronn@uni.lu	michel.mittelbronn@uni.lu	PROPN
fnp-6316	5	7	submitted	submit	VERB
fnp-6316	5	8	:	:	PUNCT
fnp-6316	5	9	23	23	NUM
fnp-6316	5	10	february	february	NOUN
fnp-6316	5	11	2025	2025	NUM
fnp-6316	5	12	·	·	PUNCT
fnp-6316	5	13	accepted	accept	VERB
fnp-6316	5	14	:	:	PUNCT
fnp-6316	5	15	17	17	NUM
fnp-6316	5	16	march	march	NOUN
fnp-6316	5	17	2025	2025	NUM
fnp-6316	5	18	·	·	PUNCT
fnp-6316	5	19	copyedited	copyedit	VERB
fnp-6316	5	20	by	by	ADP
fnp-6316	5	21	:	:	PUNCT
fnp-6316	5	22	joão	joão	PROPN
fnp-6316	5	23	gama	gama	X
fnp-6316	5	24	·	·	PUNCT
fnp-6316	5	25	published	publish	VERB
fnp-6316	5	26	:	:	PUNCT
fnp-6316	5	27	26	26	NUM
fnp-6316	5	28	march	march	NOUN
fnp-6316	5	29	2025	2025	NUM
fnp-6316	5	30	abstract	abstract	ADJ
fnp-6316	5	31	this	this	DET
fnp-6316	5	32	collection	collection	NOUN
fnp-6316	5	33	of	of	ADP
fnp-6316	5	34	studies	study	NOUN
fnp-6316	5	35	highlights	highlight	NOUN
fnp-6316	5	36	groundbreaking	groundbreake	VERB
fnp-6316	5	37	advancements	advancement	NOUN
fnp-6316	5	38	in	in	ADP
fnp-6316	5	39	brain	brain	NOUN
fnp-6316	5	40	tumor	tumor	NOUN
fnp-6316	5	41	research	research	NOUN
fnp-6316	5	42	,	,	PUNCT
fnp-6316	5	43	particularly	particularly	ADV
fnp-6316	5	44	primary	primary	ADJ
fnp-6316	5	45	cns	cns	NOUN
fnp-6316	5	46	tumors	tumor	NOUN
fnp-6316	5	47	and	and	CCONJ
fnp-6316	5	48	brain	brain	NOUN
fnp-6316	5	49	metastasis	metastasis	NOUN
fnp-6316	5	50	.	.	PUNCT
fnp-6316	6	1	one	one	NUM
fnp-6316	6	2	major	major	ADJ
fnp-6316	6	3	focus	focus	NOUN
fnp-6316	6	4	is	be	AUX
fnp-6316	6	5	the	the	DET
fnp-6316	6	6	tumor	tumor	NOUN
fnp-6316	6	7	microenvironment	microenvironment	NOUN
fnp-6316	6	8	,	,	PUNCT
fnp-6316	6	9	where	where	SCONJ
fnp-6316	6	10	alterations	alteration	NOUN
fnp-6316	6	11	in	in	ADP
fnp-6316	6	12	cerebral	cerebral	ADJ
fnp-6316	6	13	microcirculation	microcirculation	NOUN
fnp-6316	6	14	and	and	CCONJ
fnp-6316	6	15	hypoxic	hypoxic	ADJ
fnp-6316	6	16	-	-	PUNCT
fnp-6316	6	17	ischemic	ischemic	ADJ
fnp-6316	6	18	conditions	condition	NOUN
fnp-6316	6	19	have	have	AUX
fnp-6316	6	20	been	be	AUX
fnp-6316	6	21	shown	show	VERB
fnp-6316	6	22	to	to	PART
fnp-6316	6	23	influence	influence	VERB
fnp-6316	6	24	metastatic	metastatic	ADJ
fnp-6316	6	25	progression	progression	NOUN
fnp-6316	6	26	.	.	PUNCT
fnp-6316	7	1	in	in	ADP
fnp-6316	7	2	glioblastoma	glioblastoma	NOUN
fnp-6316	7	3	,	,	PUNCT
fnp-6316	7	4	recurrent	recurrent	ADJ
fnp-6316	7	5	tumors	tumor	NOUN
fnp-6316	7	6	exhibit	exhibit	VERB
fnp-6316	7	7	distinct	distinct	ADJ
fnp-6316	7	8	dna	dna	PROPN
fnp-6316	7	9	methylation	methylation	NOUN
fnp-6316	7	10	profiles	profile	NOUN
fnp-6316	7	11	,	,	PUNCT
fnp-6316	7	12	and	and	CCONJ
fnp-6316	7	13	global	global	ADJ
fnp-6316	7	14	dna	dna	PROPN
fnp-6316	7	15	methylation	methylation	NOUN
fnp-6316	7	16	has	have	AUX
fnp-6316	7	17	emerged	emerge	VERB
fnp-6316	7	18	as	as	ADP
fnp-6316	7	19	an	an	DET
fnp-6316	7	20	independent	independent	ADJ
fnp-6316	7	21	diagnostic	diagnostic	ADJ
fnp-6316	7	22	marker	marker	NOUN
fnp-6316	7	23	for	for	ADP
fnp-6316	7	24	idh	idh	NOUN
fnp-6316	7	25	-	-	PUNCT
fnp-6316	7	26	wildtype	wildtype	NOUN
fnp-6316	7	27	glioblastoma	glioblastoma	NOUN
fnp-6316	7	28	.	.	PUNCT
fnp-6316	8	1	a	a	DET
fnp-6316	8	2	whole	whole	ADJ
fnp-6316	8	3	-	-	PUNCT
fnp-6316	8	4	tumor	tumor	NOUN
fnp-6316	8	5	perspective	perspective	NOUN
fnp-6316	8	6	further	far	ADV
fnp-6316	8	7	emphasizes	emphasize	VERB
fnp-6316	8	8	the	the	DET
fnp-6316	8	9	extensive	extensive	ADJ
fnp-6316	8	10	intratumoral	intratumoral	ADJ
fnp-6316	8	11	heterogeneity	heterogeneity	NOUN
fnp-6316	8	12	driving	drive	VERB
fnp-6316	8	13	glioblastoma	glioblastoma	NOUN
fnp-6316	8	14	evolution	evolution	NOUN
fnp-6316	8	15	.	.	PUNCT
fnp-6316	9	1	the	the	DET
fnp-6316	9	2	immune	immune	ADJ
fnp-6316	9	3	landscape	landscape	NOUN
fnp-6316	9	4	of	of	ADP
fnp-6316	9	5	glioblastoma	glioblastoma	NOUN
fnp-6316	9	6	is	be	AUX
fnp-6316	9	7	another	another	DET
fnp-6316	9	8	key	key	ADJ
fnp-6316	9	9	area	area	NOUN
fnp-6316	9	10	of	of	ADP
fnp-6316	9	11	research	research	NOUN
fnp-6316	9	12	.	.	PUNCT
fnp-6316	10	1	cranioencephalic	cranioencephalic	ADJ
fnp-6316	10	2	functional	functional	ADJ
fnp-6316	10	3	lymphoid	lymphoid	NOUN
fnp-6316	10	4	units	unit	NOUN
fnp-6316	10	5	have	have	AUX
fnp-6316	10	6	been	be	AUX
fnp-6316	10	7	implicated	implicate	VERB
fnp-6316	10	8	in	in	ADP
fnp-6316	10	9	tumor	tumor	NOUN
fnp-6316	10	10	progression	progression	NOUN
fnp-6316	10	11	,	,	PUNCT
fnp-6316	10	12	while	while	SCONJ
fnp-6316	10	13	time	time	NOUN
fnp-6316	10	14	-	-	PUNCT
fnp-6316	10	15	dependent	dependent	ADJ
fnp-6316	10	16	single	single	ADJ
fnp-6316	10	17	-	-	PUNCT
fnp-6316	10	18	cell	cell	NOUN
fnp-6316	10	19	phenotyping	phenotyping	NOUN
fnp-6316	10	20	offers	offer	VERB
fnp-6316	10	21	novel	novel	ADJ
fnp-6316	10	22	insights	insight	NOUN
fnp-6316	10	23	into	into	ADP
fnp-6316	10	24	immune	immune	ADJ
fnp-6316	10	25	cell	cell	NOUN
fnp-6316	10	26	dynamics	dynamic	NOUN
fnp-6316	10	27	within	within	ADP
fnp-6316	10	28	glioblastoma	glioblastoma	NOUN
fnp-6316	10	29	.	.	PUNCT
fnp-6316	11	1	additionally	additionally	ADV
fnp-6316	11	2	,	,	PUNCT
fnp-6316	11	3	histone	histone	NOUN
fnp-6316	11	4	serotonylation	serotonylation	NOUN
fnp-6316	11	5	has	have	AUX
fnp-6316	11	6	been	be	AUX
fnp-6316	11	7	identified	identify	VERB
fnp-6316	11	8	as	as	ADP
fnp-6316	11	9	a	a	DET
fnp-6316	11	10	critical	critical	ADJ
fnp-6316	11	11	epigenetic	epigenetic	ADJ
fnp-6316	11	12	regulator	regulator	NOUN
fnp-6316	11	13	in	in	ADP
fnp-6316	11	14	ependymoma	ependymoma	NOUN
fnp-6316	11	15	tumorigenesis	tumorigenesis	NOUN
fnp-6316	11	16	.	.	PUNCT
fnp-6316	12	1	diagnostic	diagnostic	ADJ
fnp-6316	12	2	and	and	CCONJ
fnp-6316	12	3	prognostic	prognostic	ADJ
fnp-6316	12	4	innovations	innovation	NOUN
fnp-6316	12	5	are	be	AUX
fnp-6316	12	6	paving	pave	VERB
fnp-6316	12	7	the	the	DET
fnp-6316	12	8	way	way	NOUN
fnp-6316	12	9	for	for	ADP
fnp-6316	12	10	improved	improved	ADJ
fnp-6316	12	11	patient	patient	ADJ
fnp-6316	12	12	care	care	NOUN
fnp-6316	12	13	.	.	PUNCT
fnp-6316	13	1	histomorphological	histomorphological	ADJ
fnp-6316	13	2	features	feature	NOUN
fnp-6316	13	3	provide	provide	VERB
fnp-6316	13	4	enhanced	enhanced	ADJ
fnp-6316	13	5	prognosis	prognosis	NOUN
fnp-6316	13	6	prediction	prediction	NOUN
fnp-6316	13	7	for	for	ADP
fnp-6316	13	8	glioblastoma	glioblastoma	NOUN
fnp-6316	13	9	patients	patient	NOUN
fnp-6316	13	10	.	.	PUNCT
fnp-6316	14	1	confocal	confocal	ADJ
fnp-6316	14	2	laser	laser	NOUN
fnp-6316	14	3	microscopy	microscopy	NOUN
fnp-6316	14	4	enables	enable	VERB
fnp-6316	14	5	real	real	ADJ
fnp-6316	14	6	-	-	PUNCT
fnp-6316	14	7	time	time	NOUN
fnp-6316	14	8	intraoperative	intraoperative	ADJ
fnp-6316	14	9	histopathological	histopathological	ADJ
fnp-6316	14	10	diagnostics	diagnostic	NOUN
fnp-6316	14	11	,	,	PUNCT
fnp-6316	14	12	and	and	CCONJ
fnp-6316	14	13	sequencing	sequencing	NOUN
fnp-6316	14	14	of	of	ADP
fnp-6316	14	15	cerebrospinal	cerebrospinal	ADJ
fnp-6316	14	16	fluid	fluid	NOUN
fnp-6316	14	17	-	-	PUNCT
fnp-6316	14	18	derived	derive	VERB
fnp-6316	14	19	cell	cell	NOUN
fnp-6316	14	20	-	-	PUNCT
fnp-6316	14	21	free	free	ADJ
fnp-6316	14	22	dna	dna	PROPN
fnp-6316	14	23	presents	present	VERB
fnp-6316	14	24	a	a	DET
fnp-6316	14	25	promising	promising	ADJ
fnp-6316	14	26	non	non	ADJ
fnp-6316	14	27	-	-	ADJ
fnp-6316	14	28	invasive	invasive	ADJ
fnp-6316	14	29	diagnostic	diagnostic	ADJ
fnp-6316	14	30	approach	approach	NOUN
fnp-6316	14	31	.	.	PUNCT
fnp-6316	15	1	together	together	ADV
fnp-6316	15	2	,	,	PUNCT
fnp-6316	15	3	these	these	DET
fnp-6316	15	4	top	top	ADJ
fnp-6316	15	5	studies	study	NOUN
fnp-6316	15	6	of	of	ADP
fnp-6316	15	7	2024	2024	NUM
fnp-6316	15	8	underscore	underscore	VERB
fnp-6316	15	9	the	the	DET
fnp-6316	15	10	complexity	complexity	NOUN
fnp-6316	15	11	of	of	ADP
fnp-6316	15	12	brain	brain	NOUN
fnp-6316	15	13	tumor	tumor	NOUN
fnp-6316	15	14	biology	biology	NOUN
fnp-6316	15	15	and	and	CCONJ
fnp-6316	15	16	the	the	DET
fnp-6316	15	17	integration	integration	NOUN
fnp-6316	15	18	of	of	ADP
fnp-6316	15	19	epigenetics	epigenetic	NOUN
fnp-6316	15	20	,	,	PUNCT
fnp-6316	15	21	immune	immune	ADJ
fnp-6316	15	22	interactions	interaction	NOUN
fnp-6316	15	23	,	,	PUNCT
fnp-6316	15	24	and	and	CCONJ
fnp-6316	15	25	advanced	advanced	ADJ
fnp-6316	15	26	diagnostics	diagnostic	NOUN
fnp-6316	15	27	into	into	ADP
fnp-6316	15	28	clinical	clinical	ADJ
fnp-6316	15	29	practice	practice	NOUN
fnp-6316	15	30	.	.	PUNCT
fnp-6316	16	1	these	these	DET
fnp-6316	16	2	insights	insight	NOUN
fnp-6316	16	3	mark	mark	VERB
fnp-6316	16	4	significant	significant	ADJ
fnp-6316	16	5	progress	progress	NOUN
fnp-6316	16	6	toward	toward	ADP
fnp-6316	16	7	personalized	personalized	ADJ
fnp-6316	16	8	treatment	treatment	NOUN
fnp-6316	16	9	strategies	strategy	NOUN
fnp-6316	16	10	and	and	CCONJ
fnp-6316	16	11	improved	improve	VERB
fnp-6316	16	12	outcomes	outcome	NOUN
fnp-6316	16	13	in	in	ADP
fnp-6316	16	14	neurooncology	neurooncology	NOUN
fnp-6316	16	15	.	.	PUNCT
fnp-6316	17	1	keywords	keyword	NOUN
fnp-6316	17	2	:	:	PUNCT
fnp-6316	17	3	neurooncology	neurooncology	NOUN
fnp-6316	17	4	,	,	PUNCT
fnp-6316	17	5	neuropathology	neuropathology	NOUN
fnp-6316	17	6	,	,	PUNCT
fnp-6316	17	7	brain	brain	NOUN
fnp-6316	17	8	tumors	tumor	NOUN
fnp-6316	17	9	,	,	PUNCT
fnp-6316	17	10	glioblastoma	glioblastoma	NOUN
fnp-6316	17	11	,	,	PUNCT
fnp-6316	17	12	brain	brain	NOUN
fnp-6316	17	13	metastasis	metastasis	NOUN
fnp-6316	17	14	introduction	introduction	NOUN
fnp-6316	17	15	artificial	artificial	ADJ
fnp-6316	17	16	intelligence	intelligence	NOUN
fnp-6316	17	17	is	be	AUX
fnp-6316	17	18	currently	currently	ADV
fnp-6316	17	19	a	a	DET
fnp-6316	17	20	hot	hot	ADJ
fnp-6316	17	21	topic	topic	NOUN
fnp-6316	17	22	and	and	CCONJ
fnp-6316	17	23	is	be	AUX
fnp-6316	17	24	intended	intend	VERB
fnp-6316	17	25	to	to	PART
fnp-6316	17	26	make	make	VERB
fnp-6316	17	27	work	work	NOUN
fnp-6316	17	28	easier	easy	ADJ
fnp-6316	17	29	for	for	ADP
fnp-6316	17	30	humans	human	NOUN
fnp-6316	17	31	.	.	PUNCT
fnp-6316	18	1	however	however	ADV
fnp-6316	18	2	,	,	PUNCT
fnp-6316	18	3	there	there	PRON
fnp-6316	18	4	are	be	VERB
fnp-6316	18	5	still	still	ADV
fnp-6316	18	6	numerous	numerous	ADJ
fnp-6316	18	7	challenges	challenge	NOUN
fnp-6316	18	8	in	in	ADP
fnp-6316	18	9	academic	academic	ADJ
fnp-6316	18	10	literature	literature	NOUN
fnp-6316	18	11	research	research	NOUN
fnp-6316	18	12	,	,	PUNCT
fnp-6316	18	13	particularly	particularly	ADV
fnp-6316	18	14	due	due	ADJ
fnp-6316	18	15	to	to	ADP
fnp-6316	18	16	hallucinations	hallucination	NOUN
fnp-6316	18	17	that	that	PRON
fnp-6316	18	18	lead	lead	VERB
fnp-6316	18	19	to	to	ADP
fnp-6316	18	20	the	the	DET
fnp-6316	18	21	generation	generation	NOUN
fnp-6316	18	22	of	of	ADP
fnp-6316	18	23	inconsistent	inconsistent	ADJ
fnp-6316	18	24	or	or	CCONJ
fnp-6316	18	25	completely	completely	ADV
fnp-6316	18	26	incorrect	incorrect	ADJ
fnp-6316	18	27	references	reference	NOUN
fnp-6316	18	28	[	[	X
fnp-6316	18	29	albuck	albuck	NOUN
fnp-6316	18	30	et	et	NOUN
fnp-6316	18	31	al	al	PROPN
fnp-6316	18	32	.	.	PROPN
fnp-6316	18	33	,	,	PUNCT
fnp-6316	18	34	2024	2024	NUM
fnp-6316	18	35	]	]	PUNCT
fnp-6316	18	36	.	.	PUNCT
fnp-6316	19	1	nevertheless	nevertheless	ADV
fnp-6316	19	2	,	,	PUNCT
fnp-6316	19	3	the	the	DET
fnp-6316	19	4	author	author	NOUN
fnp-6316	19	5	of	of	ADP
fnp-6316	19	6	the	the	DET
fnp-6316	19	7	current	current	ADJ
fnp-6316	19	8	article	article	NOUN
fnp-6316	19	9	wanted	want	VERB
fnp-6316	19	10	to	to	PART
fnp-6316	19	11	give	give	VERB
fnp-6316	19	12	it	it	PRON
fnp-6316	19	13	a	a	DET
fnp-6316	19	14	try	try	NOUN
fnp-6316	19	15	to	to	PART
fnp-6316	19	16	see	see	VERB
fnp-6316	19	17	whether	whether	SCONJ
fnp-6316	19	18	his	his	PRON
fnp-6316	19	19	work	work	NOUN
fnp-6316	19	20	could	could	AUX
fnp-6316	19	21	be	be	AUX
fnp-6316	19	22	simplified	simplify	VERB
fnp-6316	19	23	through	through	ADP
fnp-6316	19	24	the	the	DET
fnp-6316	19	25	use	use	NOUN
fnp-6316	19	26	of	of	ADP
fnp-6316	19	27	artificial	artificial	ADJ
fnp-6316	19	28	intelligence	intelligence	NOUN
fnp-6316	19	29	,	,	PUNCT
fnp-6316	19	30	or	or	CCONJ
fnp-6316	19	31	more	more	ADV
fnp-6316	19	32	specifically	specifically	ADV
fnp-6316	19	33	,	,	PUNCT
fnp-6316	19	34	large	large	ADJ
fnp-6316	19	35	language	language	NOUN
fnp-6316	19	36	models	model	NOUN
fnp-6316	19	37	review	review	VERB
fnp-6316	19	38	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	19	39	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-6316	19	40	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-6316	19	41	mailto:michel.mittelbronn@uni.lu	mailto:michel.mittelbronn@uni.lu	ADV
fnp-6316	19	42	free	free	ADJ
fnp-6316	19	43	neuropathology	neuropathology	NOUN
fnp-6316	19	44	6:10	6:10	NUM
fnp-6316	19	45	(	(	PUNCT
fnp-6316	19	46	2025	2025	NUM
fnp-6316	19	47	)	)	PUNCT
fnp-6316	19	48	michel	michel	PROPN
fnp-6316	19	49	mittelbronn	mittelbronn	PROPN
fnp-6316	19	50	doi	doi	PROPN
fnp-6316	19	51	:	:	PUNCT
fnp-6316	19	52	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	19	53	page	page	NOUN
fnp-6316	19	54	2	2	NUM
fnp-6316	19	55	of	of	ADP
fnp-6316	19	56	19	19	NUM
fnp-6316	19	57	(	(	PUNCT
fnp-6316	19	58	llms	llm	NOUN
fnp-6316	19	59	)	)	PUNCT
fnp-6316	19	60	,	,	PUNCT
fnp-6316	19	61	or	or	CCONJ
fnp-6316	19	62	at	at	ADP
fnp-6316	19	63	least	least	ADJ
fnp-6316	19	64	gain	gain	VERB
fnp-6316	19	65	some	some	DET
fnp-6316	19	66	additional	additional	ADJ
fnp-6316	19	67	inspiration	inspiration	NOUN
fnp-6316	19	68	about	about	ADP
fnp-6316	19	69	interesting	interesting	ADJ
fnp-6316	19	70	primary	primary	ADJ
fnp-6316	19	71	research	research	NOUN
fnp-6316	19	72	articles	article	NOUN
fnp-6316	19	73	in	in	ADP
fnp-6316	19	74	the	the	DET
fnp-6316	19	75	field	field	NOUN
fnp-6316	19	76	of	of	ADP
fnp-6316	19	77	neurooncology	neurooncology	NOUN
fnp-6316	19	78	published	publish	VERB
fnp-6316	19	79	in	in	ADP
fnp-6316	19	80	2024	2024	NUM
fnp-6316	19	81	.	.	PUNCT
fnp-6316	20	1	therefore	therefore	ADV
fnp-6316	20	2	,	,	PUNCT
fnp-6316	20	3	the	the	DET
fnp-6316	20	4	following	follow	VERB
fnp-6316	20	5	very	very	ADV
fnp-6316	20	6	generic	generic	ADJ
fnp-6316	20	7	question	question	NOUN
fnp-6316	20	8	was	be	AUX
fnp-6316	20	9	posed	pose	VERB
fnp-6316	20	10	to	to	ADP
fnp-6316	20	11	three	three	NUM
fnp-6316	20	12	llms	llm	NOUN
fnp-6316	20	13	(	(	PUNCT
fnp-6316	20	14	https://chatgpt.com/	https://chatgpt.com/	NOUN
fnp-6316	20	15	;	;	PUNCT
fnp-6316	20	16	https://gemini.google.com/app	https://gemini.google.com/app	PROPN
fnp-6316	20	17	and	and	CCONJ
fnp-6316	20	18	https://www.perplexity.ai	https://www.perplexity.ai	NOUN
fnp-6316	20	19	):	):	PUNCT
fnp-6316	20	20	‘	'	PUNCT
fnp-6316	20	21	could	could	AUX
fnp-6316	20	22	you	you	PRON
fnp-6316	20	23	please	please	INTJ
fnp-6316	20	24	provide	provide	VERB
fnp-6316	20	25	me	i	PRON
fnp-6316	20	26	with	with	ADP
fnp-6316	20	27	the	the	DET
fnp-6316	20	28	10	10	NUM
fnp-6316	20	29	most	most	ADV
fnp-6316	20	30	influential	influential	ADJ
fnp-6316	20	31	primary	primary	ADJ
fnp-6316	20	32	research	research	NOUN
fnp-6316	20	33	papers	paper	NOUN
fnp-6316	20	34	published	publish	VERB
fnp-6316	20	35	in	in	ADP
fnp-6316	20	36	neurooncology	neurooncology	NOUN
fnp-6316	20	37	with	with	ADP
fnp-6316	20	38	a	a	DET
fnp-6316	20	39	link	link	NOUN
fnp-6316	20	40	to	to	ADP
fnp-6316	20	41	neuropathology	neuropathology	NOUN
fnp-6316	20	42	in	in	ADP
fnp-6316	20	43	the	the	DET
fnp-6316	20	44	year	year	NOUN
fnp-6316	20	45	2024	2024	NUM
fnp-6316	20	46	?	?	PUNCT
fnp-6316	20	47	’	'	PUNCT
fnp-6316	20	48	.	.	PUNCT
fnp-6316	21	1	chatgpt	chatgpt	PROPN
fnp-6316	21	2	proposed	propose	VERB
fnp-6316	21	3	several	several	ADJ
fnp-6316	21	4	non	non	ADJ
fnp-6316	21	5	-	-	ADJ
fnp-6316	21	6	existent	existent	ADJ
fnp-6316	21	7	articles	article	NOUN
fnp-6316	21	8	,	,	PUNCT
fnp-6316	21	9	including	include	VERB
fnp-6316	21	10	a	a	DET
fnp-6316	21	11	review	review	NOUN
fnp-6316	21	12	article	article	NOUN
fnp-6316	21	13	supposedly	supposedly	ADV
fnp-6316	21	14	authored	author	VERB
fnp-6316	21	15	by	by	ADP
fnp-6316	21	16	the	the	DET
fnp-6316	21	17	writer	writer	NOUN
fnp-6316	21	18	of	of	ADP
fnp-6316	21	19	the	the	DET
fnp-6316	21	20	present	present	ADJ
fnp-6316	21	21	review	review	NOUN
fnp-6316	21	22	.	.	PUNCT
fnp-6316	22	1	however	however	ADV
fnp-6316	22	2	,	,	PUNCT
fnp-6316	22	3	it	it	PRON
fnp-6316	22	4	altered	alter	VERB
fnp-6316	22	5	the	the	DET
fnp-6316	22	6	author	author	NOUN
fnp-6316	22	7	list	list	NOUN
fnp-6316	22	8	as	as	SCONJ
fnp-6316	22	9	follows	follow	VERB
fnp-6316	22	10	:	:	PUNCT
fnp-6316	22	11	'	'	PUNCT
fnp-6316	22	12	neurooncology	neurooncology	NOUN
fnp-6316	22	13	:	:	PUNCT
fnp-6316	22	14	2023	2023	NUM
fnp-6316	22	15	update	update	NOUN
fnp-6316	22	16	'	'	PUNCT
fnp-6316	22	17	;	;	PUNCT
fnp-6316	22	18	authors	author	NOUN
fnp-6316	22	19	:	:	PUNCT
fnp-6316	22	20	wisoff	wisoff	PROPN
fnp-6316	22	21	jh	jh	PROPN
fnp-6316	22	22	,	,	PUNCT
fnp-6316	22	23	sanford	sanford	PROPN
fnp-6316	22	24	ra	ra	PROPN
fnp-6316	22	25	,	,	PUNCT
fnp-6316	22	26	heier	heier	X
fnp-6316	22	27	la	la	PROPN
fnp-6316	22	28	,	,	PUNCT
fnp-6316	22	29	et	et	PROPN
fnp-6316	22	30	al	al	PROPN
fnp-6316	22	31	.	.	PROPN
fnp-6316	22	32	published	publish	VERB
fnp-6316	22	33	in	in	ADP
fnp-6316	22	34	:	:	PUNCT
fnp-6316	22	35	free	free	ADJ
fnp-6316	22	36	neuropathology	neuropathology	NOUN
fnp-6316	22	37	,	,	PUNCT
fnp-6316	22	38	2023	2023	NUM
fnp-6316	22	39	[	[	X
fnp-6316	22	40	mittelbronn	mittelbronn	X
fnp-6316	22	41	,	,	PUNCT
fnp-6316	22	42	2023	2023	NUM
fnp-6316	22	43	]	]	PUNCT
fnp-6316	22	44	.	.	PUNCT
fnp-6316	23	1	in	in	ADP
fnp-6316	23	2	addition	addition	NOUN
fnp-6316	23	3	,	,	PUNCT
fnp-6316	23	4	5	5	NUM
fnp-6316	23	5	of	of	ADP
fnp-6316	23	6	the	the	DET
fnp-6316	23	7	10	10	NUM
fnp-6316	23	8	proposed	propose	VERB
fnp-6316	23	9	'	'	PUNCT
fnp-6316	23	10	primary	primary	ADJ
fnp-6316	23	11	research	research	NOUN
fnp-6316	23	12	papers	paper	NOUN
fnp-6316	23	13	'	'	PUNCT
fnp-6316	23	14	were	be	AUX
fnp-6316	23	15	actually	actually	ADV
fnp-6316	23	16	podcasts	podcast	NOUN
fnp-6316	23	17	.	.	PUNCT
fnp-6316	24	1	by	by	ADP
fnp-6316	24	2	rephrasing	rephrase	VERB
fnp-6316	24	3	and	and	CCONJ
fnp-6316	24	4	adjust	adjust	VERB
fnp-6316	24	5	ing	ing	ADJ
fnp-6316	24	6	the	the	DET
fnp-6316	24	7	prompt	prompt	NOUN
fnp-6316	24	8	,	,	PUNCT
fnp-6316	24	9	some	some	DET
fnp-6316	24	10	improvements	improvement	NOUN
fnp-6316	24	11	and	and	CCONJ
fnp-6316	24	12	correct	correct	ADJ
fnp-6316	24	13	ions	ion	NOUN
fnp-6316	24	14	were	be	AUX
fnp-6316	24	15	achieved	achieve	VERB
fnp-6316	24	16	;	;	PUNCT
fnp-6316	24	17	however	however	ADV
fnp-6316	24	18	,	,	PUNCT
fnp-6316	24	19	the	the	DET
fnp-6316	24	20	results	result	NOUN
fnp-6316	24	21	improved	improve	VERB
fnp-6316	24	22	only	only	ADV
fnp-6316	24	23	partially	partially	ADV
fnp-6316	24	24	and	and	CCONJ
fnp-6316	24	25	gradually	gradually	ADV
fnp-6316	24	26	.	.	PUNCT
fnp-6316	25	1	perplexity	perplexity	NOUN
fnp-6316	25	2	suggested	suggest	VERB
fnp-6316	25	3	exactly	exactly	ADV
fnp-6316	25	4	the	the	DET
fnp-6316	25	5	10	10	NUM
fnp-6316	25	6	papers	paper	NOUN
fnp-6316	25	7	from	from	ADP
fnp-6316	25	8	the	the	DET
fnp-6316	25	9	top	top	ADJ
fnp-6316	25	10	10	10	NUM
fnp-6316	25	11	series	series	NOUN
fnp-6316	25	12	in	in	ADP
fnp-6316	25	13	neurooncology	neurooncology	NOUN
fnp-6316	25	14	published	publish	VERB
fnp-6316	25	15	in	in	ADP
fnp-6316	25	16	free	free	ADJ
fnp-6316	25	17	neuropathology	neuropathology	NOUN
fnp-6316	25	18	last	last	ADJ
fnp-6316	25	19	year	year	NOUN
fnp-6316	25	20	but	but	CCONJ
fnp-6316	25	21	re	re	VERB
fnp-6316	25	22	-	-	VERB
fnp-6316	25	23	dated	date	VERB
fnp-6316	25	24	all	all	DET
fnp-6316	25	25	articles	article	NOUN
fnp-6316	25	26	from	from	ADP
fnp-6316	25	27	2023	2023	NUM
fnp-6316	25	28	to	to	ADP
fnp-6316	25	29	2024	2024	NUM
fnp-6316	25	30	[	[	X
fnp-6316	25	31	mittelbronn	mittelbronn	X
fnp-6316	25	32	,	,	PUNCT
fnp-6316	25	33	2024	2024	NUM
fnp-6316	25	34	]	]	PUNCT
fnp-6316	25	35	.	.	PUNCT
fnp-6316	26	1	after	after	ADP
fnp-6316	26	2	being	be	AUX
fnp-6316	26	3	re	re	VERB
fnp-6316	26	4	-	-	VERB
fnp-6316	26	5	prompted	prompt	VERB
fnp-6316	26	6	,	,	PUNCT
fnp-6316	26	7	perplexity	perplexity	NOUN
fnp-6316	26	8	explained	explain	VERB
fnp-6316	26	9	that	that	SCONJ
fnp-6316	26	10	it	it	PRON
fnp-6316	26	11	would	would	AUX
fnp-6316	26	12	be	be	AUX
fnp-6316	26	13	inappropriate	inappropriate	ADJ
fnp-6316	26	14	to	to	PART
fnp-6316	26	15	speculate	speculate	VERB
fnp-6316	26	16	or	or	CCONJ
fnp-6316	26	17	provide	provide	VERB
fnp-6316	26	18	inaccurate	inaccurate	ADJ
fnp-6316	26	19	information	information	NOUN
fnp-6316	26	20	about	about	ADP
fnp-6316	26	21	influential	influential	ADJ
fnp-6316	26	22	papers	paper	NOUN
fnp-6316	26	23	from	from	ADP
fnp-6316	26	24	2024	2024	NUM
fnp-6316	26	25	.	.	PUNCT
fnp-6316	27	1	only	only	ADV
fnp-6316	27	2	gemini	gemini	NOUN
fnp-6316	27	3	–	–	PUNCT
fnp-6316	27	4	both	both	PRON
fnp-6316	27	5	initially	initially	ADV
fnp-6316	27	6	and	and	CCONJ
fnp-6316	27	7	after	after	ADP
fnp-6316	27	8	several	several	ADJ
fnp-6316	27	9	attempts	attempt	NOUN
fnp-6316	27	10	or	or	CCONJ
fnp-6316	27	11	re	re	VERB
fnp-6316	27	12	-	-	ADJ
fnp-6316	27	13	prompting	prompt	VERB
fnp-6316	27	14	–	–	PUNCT
fnp-6316	27	15	refused	refuse	VERB
fnp-6316	27	16	to	to	PART
fnp-6316	27	17	provide	provide	VERB
fnp-6316	27	18	some	some	DET
fnp-6316	27	19	suggestions	suggestion	NOUN
fnp-6316	27	20	of	of	ADP
fnp-6316	27	21	real	real	ADJ
fnp-6316	27	22	scientific	scientific	ADJ
fnp-6316	27	23	papers	paper	NOUN
fnp-6316	27	24	,	,	PUNCT
fnp-6316	27	25	instead	instead	ADV
fnp-6316	27	26	recommending	recommend	VERB
fnp-6316	27	27	journals	journal	NOUN
fnp-6316	27	28	,	,	PUNCT
fnp-6316	27	29	search	search	NOUN
fnp-6316	27	30	engines	engine	NOUN
fnp-6316	27	31	such	such	ADJ
fnp-6316	27	32	as	as	ADP
fnp-6316	27	33	pubmed	pubmed	PROPN
fnp-6316	27	34	(	(	PUNCT
fnp-6316	27	35	https://pubmed.ncbi.nlm	https://pubmed.ncbi.nlm	PROPN
fnp-6316	27	36	.	.	PUNCT
fnp-6316	27	37	nih.gov/	nih.gov/	NOUN
fnp-6316	27	38	)	)	PUNCT
fnp-6316	27	39	or	or	CCONJ
fnp-6316	27	40	google	google	PROPN
fnp-6316	27	41	scholar	scholar	NOUN
fnp-6316	27	42	(	(	PUNCT
fnp-6316	27	43	https://scholar.google	https://scholar.google	PROPN
fnp-6316	27	44	.	.	PUNCT
fnp-6316	28	1	com/	com/	NOUN
fnp-6316	28	2	)	)	PUNCT
fnp-6316	28	3	.	.	PUNCT
fnp-6316	29	1	as	as	ADP
fnp-6316	29	2	a	a	DET
fnp-6316	29	3	result	result	NOUN
fnp-6316	29	4	,	,	PUNCT
fnp-6316	29	5	unfortunately	unfortunately	ADV
fnp-6316	29	6	,	,	PUNCT
fnp-6316	29	7	not	not	PART
fnp-6316	29	8	a	a	DET
fnp-6316	29	9	single	single	NOUN
fnp-6316	29	10	of	of	ADP
fnp-6316	29	11	the	the	DET
fnp-6316	29	12	different	different	ADJ
fnp-6316	29	13	llms	llm	NOUN
fnp-6316	29	14	was	be	AUX
fnp-6316	29	15	useful	useful	ADJ
fnp-6316	29	16	for	for	ADP
fnp-6316	29	17	the	the	DET
fnp-6316	29	18	compilation	compilation	NOUN
fnp-6316	29	19	of	of	ADP
fnp-6316	29	20	influential	influential	ADJ
fnp-6316	29	21	primary	primary	ADJ
fnp-6316	29	22	scientific	scientific	ADJ
fnp-6316	29	23	papers	paper	NOUN
fnp-6316	29	24	in	in	ADP
fnp-6316	29	25	the	the	DET
fnp-6316	29	26	field	field	NOUN
fnp-6316	29	27	of	of	ADP
fnp-6316	29	28	neurooncology	neurooncology	NOUN
fnp-6316	29	29	of	of	ADP
fnp-6316	29	30	this	this	DET
fnp-6316	29	31	year	year	NOUN
fnp-6316	29	32	’s	’s	PART
fnp-6316	29	33	edition	edition	NOUN
fnp-6316	29	34	.	.	PUNCT
fnp-6316	30	1	therefore	therefore	ADV
fnp-6316	30	2	,	,	PUNCT
fnp-6316	30	3	the	the	DET
fnp-6316	30	4	author	author	NOUN
fnp-6316	30	5	returned	return	VERB
fnp-6316	30	6	to	to	ADP
fnp-6316	30	7	a	a	DET
fnp-6316	30	8	more	more	ADV
fnp-6316	30	9	traditional	traditional	ADJ
fnp-6316	30	10	approach	approach	NOUN
fnp-6316	30	11	,	,	PUNCT
fnp-6316	30	12	screening	screen	VERB
fnp-6316	30	13	thousands	thousand	NOUN
fnp-6316	30	14	of	of	ADP
fnp-6316	30	15	titles	title	NOUN
fnp-6316	30	16	and	and	CCONJ
fnp-6316	30	17	abstracts	abstract	NOUN
fnp-6316	30	18	related	relate	VERB
fnp-6316	30	19	to	to	ADP
fnp-6316	30	20	key	key	ADJ
fnp-6316	30	21	search	search	NOUN
fnp-6316	30	22	terms	term	NOUN
fnp-6316	30	23	in	in	ADP
fnp-6316	30	24	the	the	DET
fnp-6316	30	25	field	field	NOUN
fnp-6316	30	26	(	(	PUNCT
fnp-6316	30	27	e.g.	e.g.	ADV
fnp-6316	30	28	,	,	PUNCT
fnp-6316	30	29	brain	brain	NOUN
fnp-6316	30	30	tumor	tumor	NOUN
fnp-6316	30	31	,	,	PUNCT
fnp-6316	30	32	glioma	glioma	NOUN
fnp-6316	30	33	,	,	PUNCT
fnp-6316	30	34	meningioma	meningioma	NOUN
fnp-6316	30	35	,	,	PUNCT
fnp-6316	30	36	brain	brain	NOUN
fnp-6316	30	37	metastasis	metastasis	NOUN
fnp-6316	30	38	,	,	PUNCT
fnp-6316	30	39	neurooncology	neurooncology	NOUN
fnp-6316	30	40	,	,	PUNCT
fnp-6316	30	41	etc	etc	X
fnp-6316	30	42	.	.	X
fnp-6316	30	43	)	)	PUNCT
fnp-6316	30	44	.	.	PUNCT
fnp-6316	31	1	in	in	ADP
fnp-6316	31	2	contrast	contrast	NOUN
fnp-6316	31	3	to	to	ADP
fnp-6316	31	4	last	last	ADJ
fnp-6316	31	5	year	year	NOUN
fnp-6316	31	6	,	,	PUNCT
fnp-6316	31	7	however	however	ADV
fnp-6316	31	8	,	,	PUNCT
fnp-6316	31	9	fewer	few	ADJ
fnp-6316	31	10	novel	novel	ADJ
fnp-6316	31	11	treatment	treatment	NOUN
fnp-6316	31	12	approaches	approach	NOUN
fnp-6316	31	13	in	in	ADP
fnp-6316	31	14	neurooncology	neurooncology	NOUN
fnp-6316	31	15	were	be	AUX
fnp-6316	31	16	identified	identify	VERB
fnp-6316	31	17	.	.	PUNCT
fnp-6316	32	1	of	of	ADP
fnp-6316	32	2	note	note	NOUN
fnp-6316	32	3	,	,	PUNCT
fnp-6316	32	4	with	with	ADP
fnp-6316	32	5	29	29	NUM
fnp-6316	32	6	retractions	retraction	NOUN
fnp-6316	32	7	of	of	ADP
fnp-6316	32	8	papers	paper	NOUN
fnp-6316	32	9	related	relate	VERB
fnp-6316	32	10	to	to	ADP
fnp-6316	32	11	the	the	DET
fnp-6316	32	12	keyword	keyword	NOUN
fnp-6316	32	13	'	'	PUNCT
fnp-6316	32	14	glioblastoma	glioblastoma	NOUN
fnp-6316	32	15	'	'	PUNCT
fnp-6316	32	16	in	in	ADP
fnp-6316	32	17	2024	2024	NUM
fnp-6316	32	18	(	(	PUNCT
fnp-6316	32	19	compared	compare	VERB
fnp-6316	32	20	to	to	ADP
fnp-6316	32	21	22	22	NUM
fnp-6316	32	22	in	in	ADP
fnp-6316	32	23	2023	2023	NUM
fnp-6316	32	24	and	and	CCONJ
fnp-6316	32	25	9	9	NUM
fnp-6316	32	26	in	in	ADP
fnp-6316	32	27	2022	2022	NUM
fnp-6316	32	28	,	,	PUNCT
fnp-6316	32	29	and	and	CCONJ
fnp-6316	32	30	similarly	similarly	ADV
fnp-6316	32	31	high	high	ADJ
fnp-6316	32	32	number	number	NOUN
fnp-6316	32	33	of	of	ADP
fnp-6316	32	34	publications	publication	NOUN
fnp-6316	32	35	)	)	PUNCT
fnp-6316	32	36	,	,	PUNCT
fnp-6316	32	37	along	along	ADP
fnp-6316	32	38	with	with	ADP
fnp-6316	32	39	multiple	multiple	ADJ
fnp-6316	32	40	corrections	correction	NOUN
fnp-6316	32	41	,	,	PUNCT
fnp-6316	32	42	a	a	DET
fnp-6316	32	43	worrisome	worrisome	ADJ
fnp-6316	32	44	increase	increase	NOUN
fnp-6316	32	45	in	in	ADP
fnp-6316	32	46	potentially	potentially	ADV
fnp-6316	32	47	sloppy	sloppy	ADJ
fnp-6316	32	48	scientific	scientific	ADJ
fnp-6316	32	49	behavior	behavior	NOUN
fnp-6316	32	50	in	in	ADP
fnp-6316	32	51	this	this	DET
fnp-6316	32	52	field	field	NOUN
fnp-6316	32	53	was	be	AUX
fnp-6316	32	54	observed	observe	VERB
fnp-6316	32	55	.	.	PUNCT
fnp-6316	33	1	nevertheless	nevertheless	ADV
fnp-6316	33	2	,	,	PUNCT
fnp-6316	33	3	numerous	numerous	ADJ
fnp-6316	33	4	excellent	excellent	ADJ
fnp-6316	33	5	primary	primary	ADJ
fnp-6316	33	6	research	research	NOUN
fnp-6316	33	7	articles	article	NOUN
fnp-6316	33	8	were	be	AUX
fnp-6316	33	9	identified	identify	VERB
fnp-6316	33	10	and	and	CCONJ
fnp-6316	33	11	subjective	subjective	ADJ
fnp-6316	33	12	selection	selection	NOUN
fnp-6316	33	13	was	be	AUX
fnp-6316	33	14	a	a	DET
fnp-6316	33	15	challenge	challenge	NOUN
fnp-6316	33	16	.	.	PUNCT
fnp-6316	34	1	as	as	ADP
fnp-6316	34	2	usual	usual	ADJ
fnp-6316	34	3	,	,	PUNCT
fnp-6316	34	4	the	the	DET
fnp-6316	34	5	goal	goal	NOUN
fnp-6316	34	6	was	be	AUX
fnp-6316	34	7	to	to	PART
fnp-6316	34	8	provide	provide	VERB
fnp-6316	34	9	a	a	DET
fnp-6316	34	10	collection	collection	NOUN
fnp-6316	34	11	of	of	ADP
fnp-6316	34	12	articles	article	NOUN
fnp-6316	34	13	ranging	range	VERB
fnp-6316	34	14	from	from	ADP
fnp-6316	34	15	basic	basic	ADJ
fnp-6316	34	16	research	research	NOUN
fnp-6316	34	17	findings	finding	NOUN
fnp-6316	34	18	to	to	PART
fnp-6316	34	19	novel	novel	VERB
fnp-6316	34	20	diagnostic	diagnostic	ADJ
fnp-6316	34	21	or	or	CCONJ
fnp-6316	34	22	prognostic	prognostic	ADJ
fnp-6316	34	23	criteria	criterion	NOUN
fnp-6316	34	24	,	,	PUNCT
fnp-6316	34	25	technical	technical	ADJ
fnp-6316	34	26	and	and	CCONJ
fnp-6316	34	27	methodological	methodological	ADJ
fnp-6316	34	28	innovations	innovation	NOUN
fnp-6316	34	29	,	,	PUNCT
fnp-6316	34	30	and	and	CCONJ
fnp-6316	34	31	therapeutic	therapeutic	ADJ
fnp-6316	34	32	approaches	approach	NOUN
fnp-6316	34	33	.	.	PUNCT
fnp-6316	35	1	with	with	ADP
fnp-6316	35	2	this	this	PRON
fnp-6316	35	3	,	,	PUNCT
fnp-6316	35	4	the	the	DET
fnp-6316	35	5	“	"	PUNCT
fnp-6316	35	6	top	top	ADJ
fnp-6316	35	7	ten	ten	NUM
fnp-6316	35	8	”	"	PUNCT
fnp-6316	35	9	series	series	NOUN
fnp-6316	35	10	in	in	ADP
fnp-6316	35	11	neurooncology	neurooncology	NOUN
fnp-6316	35	12	for	for	ADP
fnp-6316	35	13	2024	2024	NUM
fnp-6316	35	14	reads	read	NOUN
fnp-6316	35	15	as	as	SCONJ
fnp-6316	35	16	follows	follow	VERB
fnp-6316	35	17	:	:	PUNCT
fnp-6316	35	18	1	1	X
fnp-6316	35	19	.	.	X
fnp-6316	35	20	impact	impact	NOUN
fnp-6316	35	21	of	of	ADP
fnp-6316	35	22	cerebral	cerebral	ADJ
fnp-6316	35	23	microcirculation	microcirculation	NOUN
fnp-6316	35	24	alteration	alteration	NOUN
fnp-6316	35	25	and	and	CCONJ
fnp-6316	35	26	hypoxic	hypoxic	ADV
fnp-6316	35	27	-	-	PUNCT
fnp-6316	35	28	ischemic	ischemic	ADJ
fnp-6316	35	29	microenvironment	microenvironment	NOUN
fnp-6316	35	30	on	on	ADP
fnp-6316	35	31	brain	brain	NOUN
fnp-6316	35	32	metastasis	metastasis	NOUN
fnp-6316	35	33	development	development	NOUN
fnp-6316	35	34	[	[	X
fnp-6316	35	35	roesler	roesler	NOUN
fnp-6316	35	36	et	et	PROPN
fnp-6316	35	37	al	al	PROPN
fnp-6316	35	38	.	.	PROPN
fnp-6316	35	39	,	,	PUNCT
fnp-6316	35	40	2024	2024	NUM
fnp-6316	35	41	]	]	PUNCT
fnp-6316	35	42	.	.	PUNCT
fnp-6316	36	1	2	2	X
fnp-6316	36	2	.	.	X
fnp-6316	36	3	global	global	ADJ
fnp-6316	36	4	dna	dna	PROPN
fnp-6316	36	5	methylation	methylation	NOUN
fnp-6316	36	6	as	as	ADP
fnp-6316	36	7	independent	independent	ADJ
fnp-6316	36	8	diagnostic	diagnostic	ADJ
fnp-6316	36	9	marker	marker	NOUN
fnp-6316	36	10	in	in	ADP
fnp-6316	36	11	idh	idh	NOUN
fnp-6316	36	12	-	-	PUNCT
fnp-6316	36	13	wildtype	wildtype	NOUN
fnp-6316	36	14	glioblastoma	glioblastoma	NOUN
fnp-6316	37	1	[	[	X
fnp-6316	37	2	eckhardt	eckhardt	NOUN
fnp-6316	37	3	et	et	PROPN
fnp-6316	37	4	al	al	PROPN
fnp-6316	37	5	.	.	PROPN
fnp-6316	37	6	,	,	PUNCT
fnp-6316	37	7	2024	2024	NUM
fnp-6316	37	8	]	]	PUNCT
fnp-6316	37	9	.	.	PUNCT
fnp-6316	38	1	3	3	X
fnp-6316	38	2	.	.	X
fnp-6316	38	3	change	change	NOUN
fnp-6316	38	4	in	in	ADP
fnp-6316	38	5	dna	dna	PROPN
fnp-6316	38	6	methylation	methylation	NOUN
fnp-6316	38	7	profile	profile	NOUN
fnp-6316	38	8	in	in	ADP
fnp-6316	38	9	recurrent	recurrent	ADJ
fnp-6316	38	10	glioblastoma	glioblastoma	NOUN
fnp-6316	38	11	[	[	X
fnp-6316	38	12	drexler	drexler	NOUN
fnp-6316	38	13	et	et	PROPN
fnp-6316	38	14	al	al	PROPN
fnp-6316	38	15	.	.	PROPN
fnp-6316	38	16	,	,	PUNCT
fnp-6316	38	17	2024	2024	NUM
fnp-6316	38	18	]	]	PUNCT
fnp-6316	38	19	.	.	PUNCT
fnp-6316	39	1	4	4	X
fnp-6316	39	2	.	.	X
fnp-6316	39	3	glioblastoma	glioblastoma	NOUN
fnp-6316	39	4	evolution	evolution	NOUN
fnp-6316	39	5	and	and	CCONJ
fnp-6316	39	6	heterogeneity	heterogeneity	NOUN
fnp-6316	39	7	from	from	ADP
fnp-6316	39	8	a	a	DET
fnp-6316	39	9	whole	whole	ADJ
fnp-6316	39	10	tumor	tumor	NOUN
fnp-6316	39	11	perspective	perspective	NOUN
fnp-6316	40	1	[	[	X
fnp-6316	40	2	mathur	mathur	PROPN
fnp-6316	40	3	et	et	PROPN
fnp-6316	40	4	al	al	PROPN
fnp-6316	40	5	.	.	PROPN
fnp-6316	40	6	,	,	PUNCT
fnp-6316	40	7	2024	2024	NUM
fnp-6316	40	8	]	]	PUNCT
fnp-6316	40	9	.	.	PUNCT
fnp-6316	41	1	5	5	X
fnp-6316	41	2	.	.	X
fnp-6316	41	3	cranioencephalic	cranioencephalic	ADJ
fnp-6316	41	4	functional	functional	ADJ
fnp-6316	41	5	lymphoid	lymphoid	ADJ
fnp-6316	41	6	units	unit	NOUN
fnp-6316	41	7	in	in	ADP
fnp-6316	41	8	glioblastoma	glioblastoma	NOUN
fnp-6316	41	9	[	[	X
fnp-6316	41	10	dobersalske	dobersalske	PROPN
fnp-6316	41	11	et	et	PROPN
fnp-6316	41	12	al	al	PROPN
fnp-6316	41	13	.	.	PROPN
fnp-6316	41	14	,	,	PUNCT
fnp-6316	41	15	2024	2024	NUM
fnp-6316	41	16	]	]	PUNCT
fnp-6316	41	17	.	.	PUNCT
fnp-6316	42	1	6	6	X
fnp-6316	42	2	.	.	X
fnp-6316	42	3	prognosis	prognosis	NOUN
fnp-6316	42	4	prediction	prediction	NOUN
fnp-6316	42	5	via	via	ADP
fnp-6316	42	6	histomorphological	histomorphological	ADJ
fnp-6316	42	7	features	feature	NOUN
fnp-6316	42	8	in	in	ADP
fnp-6316	42	9	glioblastoma	glioblastoma	NOUN
fnp-6316	42	10	[	[	X
fnp-6316	42	11	kirishima	kirishima	X
fnp-6316	42	12	et	et	PROPN
fnp-6316	42	13	al	al	PROPN
fnp-6316	42	14	.	.	PROPN
fnp-6316	42	15	,	,	PUNCT
fnp-6316	42	16	2024	2024	NUM
fnp-6316	42	17	]	]	PUNCT
fnp-6316	42	18	.	.	PUNCT
fnp-6316	43	1	7	7	X
fnp-6316	43	2	.	.	X
fnp-6316	43	3	confocal	confocal	ADJ
fnp-6316	43	4	laser	laser	NOUN
fnp-6316	43	5	microscopy	microscopy	NOUN
fnp-6316	43	6	for	for	ADP
fnp-6316	43	7	intraoperative	intraoperative	ADJ
fnp-6316	43	8	histopathological	histopathological	ADJ
fnp-6316	43	9	diagnostics	diagnostic	NOUN
fnp-6316	43	10	of	of	ADP
fnp-6316	43	11	intracranial	intracranial	ADJ
fnp-6316	43	12	tumors	tumor	NOUN
fnp-6316	44	1	[	[	X
fnp-6316	44	2	wagner	wagner	X
fnp-6316	44	3	et	et	PROPN
fnp-6316	44	4	al	al	PROPN
fnp-6316	44	5	.	.	PROPN
fnp-6316	44	6	,	,	PUNCT
fnp-6316	44	7	2024	2024	NUM
fnp-6316	44	8	]	]	PUNCT
fnp-6316	44	9	.	.	PUNCT
fnp-6316	45	1	8	8	X
fnp-6316	45	2	.	.	X
fnp-6316	45	3	brain	brain	NOUN
fnp-6316	45	4	tumor	tumor	NOUN
fnp-6316	45	5	diagnostics	diagnostic	NOUN
fnp-6316	45	6	from	from	ADP
fnp-6316	45	7	cell	cell	NOUN
fnp-6316	45	8	-	-	PUNCT
fnp-6316	45	9	free	free	ADJ
fnp-6316	45	10	dna	dna	NOUN
fnp-6316	45	11	from	from	ADP
fnp-6316	45	12	cerebrospinal	cerebrospinal	ADJ
fnp-6316	45	13	fluid	fluid	NOUN
fnp-6316	45	14	[	[	X
fnp-6316	45	15	afflerbach	afflerbach	NOUN
fnp-6316	45	16	et	et	PROPN
fnp-6316	45	17	al	al	PROPN
fnp-6316	45	18	.	.	PROPN
fnp-6316	45	19	,	,	PUNCT
fnp-6316	45	20	2024	2024	NUM
fnp-6316	45	21	&	&	CCONJ
fnp-6316	45	22	hickman	hickman	PROPN
fnp-6316	45	23	et	et	PROPN
fnp-6316	45	24	al	al	PROPN
fnp-6316	45	25	.	.	PROPN
fnp-6316	45	26	,	,	PUNCT
fnp-6316	45	27	2024	2024	NUM
fnp-6316	45	28	]	]	PUNCT
fnp-6316	45	29	.	.	PUNCT
fnp-6316	46	1	9	9	NUM
fnp-6316	46	2	.	.	NOUN
fnp-6316	46	3	time	time	NOUN
fnp-6316	46	4	-	-	PUNCT
fnp-6316	46	5	dependent	dependent	ADJ
fnp-6316	46	6	single	single	ADJ
fnp-6316	46	7	-	-	PUNCT
fnp-6316	46	8	cell	cell	NOUN
fnp-6316	46	9	phenotyping	phenotyping	NOUN
fnp-6316	46	10	of	of	ADP
fnp-6316	46	11	immune	immune	ADJ
fnp-6316	46	12	cells	cell	NOUN
fnp-6316	46	13	in	in	ADP
fnp-6316	46	14	glioblastoma	glioblastoma	NOUN
fnp-6316	47	1	[	[	X
fnp-6316	47	2	kirschenbaum	kirschenbaum	NOUN
fnp-6316	47	3	et	et	PROPN
fnp-6316	47	4	al	al	PROPN
fnp-6316	47	5	.	.	PROPN
fnp-6316	47	6	,	,	PUNCT
fnp-6316	47	7	2024	2024	NUM
fnp-6316	47	8	]	]	PUNCT
fnp-6316	47	9	.	.	PUNCT
fnp-6316	48	1	10	10	NUM
fnp-6316	48	2	.	.	X
fnp-6316	48	3	histone	histone	NOUN
fnp-6316	48	4	serotonylation	serotonylation	PROPN
fnp-6316	48	5	regulates	regulate	VERB
fnp-6316	48	6	ependymoma	ependymoma	NOUN
fnp-6316	48	7	tumorigenesis	tumorigenesis	NOUN
fnp-6316	49	1	[	[	X
fnp-6316	49	2	chen	chen	PROPN
fnp-6316	49	3	et	et	PROPN
fnp-6316	49	4	al	al	PROPN
fnp-6316	49	5	.	.	PROPN
fnp-6316	49	6	,	,	PUNCT
fnp-6316	49	7	2024	2024	NUM
fnp-6316	49	8	]	]	PUNCT
fnp-6316	49	9	.	.	PUNCT
fnp-6316	50	1	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	50	2	https://eur01.safelinks.protection.outlook.com/?url=https%3a%2f%2fchatgpt.com%2f&data=05%7c02%7cmichel.mittelbronn%40ext.uni.lu%7cba0ec810e19c4ccdec7d08dd64484652%7c445a9c950f9d49539db1bc4a45dd1220%7c0%7c0%7c638776983780334547%7cunknown%7ctwfpbgzsb3d8eyjfbxb0eu1hcgkionrydwusilyioiiwljaumdawmcisilaioijxaw4zmiisikfoijoitwfpbcisilduijoyfq%3d%3d%7c0%7c%7c%7c&sdata=rshrttsmi9sswrqdpt0ikvgyhoxt8gcgfkgzfnwsrfu%3d&reserved=0	https://eur01.safelinks.protection.outlook.com/?url=https%3a%2f%2fchatgpt.com%2f&data=05%7c02%7cmichel.mittelbronn%40ext.uni.lu%7cba0ec810e19c4ccdec7d08dd64484652%7c445a9c950f9d49539db1bc4a45dd1220%7c0%7c0%7c638776983780334547%7cunknown%7ctwfpbgzsb3d8eyjfbxb0eu1hcgkionrydwusilyioiiwljaumdawmcisilaioijxaw4zmiisikfoijoitwfpbcisilduijoyfq%3d%3d%7c0%7c%7c%7c&sdata=rshrttsmi9sswrqdpt0ikvgyhoxt8gcgfkgzfnwsrfu%3d&reserved=0	PROPN
fnp-6316	50	3	https://gemini.google.com/app	https://gemini.google.com/app	PROPN
fnp-6316	50	4	https://gemini.google.com/app	https://gemini.google.com/app	PROPN
fnp-6316	50	5	https://www.perplexity.ai/	https://www.perplexity.ai/	NUM
fnp-6316	50	6	free	free	ADJ
fnp-6316	50	7	neuropathology	neuropathology	NOUN
fnp-6316	50	8	6:10	6:10	NUM
fnp-6316	50	9	(	(	PUNCT
fnp-6316	50	10	2025	2025	NUM
fnp-6316	50	11	)	)	PUNCT
fnp-6316	50	12	michel	michel	PROPN
fnp-6316	50	13	mittelbronn	mittelbronn	PROPN
fnp-6316	50	14	doi	doi	PROPN
fnp-6316	50	15	:	:	PUNCT
fnp-6316	50	16	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	50	17	page	page	NOUN
fnp-6316	50	18	3	3	NUM
fnp-6316	50	19	of	of	ADP
fnp-6316	50	20	19	19	NUM
fnp-6316	50	21	1	1	NUM
fnp-6316	50	22	.	.	PUNCT
fnp-6316	50	23	impact	impact	NOUN
fnp-6316	50	24	of	of	ADP
fnp-6316	50	25	disturbed	disturbed	ADJ
fnp-6316	50	26	cerebral	cerebral	ADJ
fnp-6316	50	27	microcirculation	microcirculation	NOUN
fnp-6316	50	28	and	and	CCONJ
fnp-6316	50	29	hypoxic	hypoxic	ADJ
fnp-6316	50	30	-	-	PUNCT
fnp-6316	50	31	ischemic	ischemic	ADJ
fnp-6316	50	32	microenvironment	microenvironment	NOUN
fnp-6316	50	33	on	on	ADP
fnp-6316	50	34	brain	brain	NOUN
fnp-6316	50	35	metastasis	metastasis	NOUN
fnp-6316	50	36	development	development	NOUN
fnp-6316	50	37	[	[	X
fnp-6316	50	38	roesler	roesler	NOUN
fnp-6316	50	39	et	et	PROPN
fnp-6316	50	40	al	al	PROPN
fnp-6316	50	41	.	.	PROPN
fnp-6316	50	42	,	,	PUNCT
fnp-6316	50	43	2024	2024	NUM
fnp-6316	50	44	]	]	PUNCT
fnp-6316	50	45	although	although	SCONJ
fnp-6316	50	46	the	the	DET
fnp-6316	50	47	basic	basic	ADJ
fnp-6316	50	48	steps	step	NOUN
fnp-6316	50	49	of	of	ADP
fnp-6316	50	50	brain	brain	NOUN
fnp-6316	50	51	metastasis	metastasis	NOUN
fnp-6316	50	52	formation	formation	NOUN
fnp-6316	50	53	,	,	PUNCT
fnp-6316	50	54	including	include	VERB
fnp-6316	50	55	–	–	PUNCT
fnp-6316	50	56	amongst	amongst	ADP
fnp-6316	50	57	others	other	NOUN
fnp-6316	50	58	–	–	PUNCT
fnp-6316	50	59	detachment	detachment	NOUN
fnp-6316	50	60	of	of	ADP
fnp-6316	50	61	cancer	cancer	NOUN
fnp-6316	50	62	cells	cell	NOUN
fnp-6316	50	63	from	from	ADP
fnp-6316	50	64	the	the	DET
fnp-6316	50	65	primary	primary	ADJ
fnp-6316	50	66	tumor	tumor	NOUN
fnp-6316	50	67	and	and	CCONJ
fnp-6316	50	68	intravasation	intravasation	NOUN
fnp-6316	50	69	into	into	ADP
fnp-6316	50	70	the	the	DET
fnp-6316	50	71	blood	blood	NOUN
fnp-6316	50	72	stream	stream	NOUN
fnp-6316	50	73	,	,	PUNCT
fnp-6316	50	74	followed	follow	VERB
fnp-6316	50	75	by	by	ADP
fnp-6316	50	76	adhesion	adhesion	NOUN
fnp-6316	50	77	to	to	PART
fnp-6316	50	78	brain	brain	VERB
fnp-6316	50	79	endothelial	endothelial	ADJ
fnp-6316	50	80	cells	cell	NOUN
fnp-6316	50	81	and	and	CCONJ
fnp-6316	50	82	finally	finally	ADV
fnp-6316	50	83	extravasation	extravasation	NOUN
fnp-6316	50	84	into	into	ADP
fnp-6316	50	85	as	as	ADV
fnp-6316	50	86	well	well	ADV
fnp-6316	50	87	as	as	ADP
fnp-6316	50	88	colonization	colonization	NOUN
fnp-6316	50	89	of	of	ADP
fnp-6316	50	90	the	the	DET
fnp-6316	50	91	brain	brain	NOUN
fnp-6316	50	92	is	be	AUX
fnp-6316	50	93	reiterated	reiterate	VERB
fnp-6316	50	94	,	,	PUNCT
fnp-6316	50	95	the	the	DET
fnp-6316	50	96	exact	exact	ADJ
fnp-6316	50	97	mechanisms	mechanism	NOUN
fnp-6316	50	98	and	and	CCONJ
fnp-6316	50	99	time	time	NOUN
fnp-6316	50	100	-	-	PUNCT
fnp-6316	50	101	dependent	dependent	ADJ
fnp-6316	50	102	sequences	sequence	NOUN
fnp-6316	50	103	are	be	AUX
fnp-6316	50	104	not	not	PART
fnp-6316	50	105	fully	fully	ADV
fnp-6316	50	106	understood	understand	VERB
fnp-6316	50	107	.	.	PUNCT
fnp-6316	51	1	in	in	ADP
fnp-6316	51	2	a	a	DET
fnp-6316	51	3	previous	previous	ADJ
fnp-6316	51	4	groundbreaking	groundbreake	VERB
fnp-6316	51	5	work	work	NOUN
fnp-6316	51	6	of	of	ADP
fnp-6316	51	7	kienast	kienast	NOUN
fnp-6316	51	8	et	et	PROPN
fnp-6316	51	9	al	al	PROPN
fnp-6316	51	10	.	.	PROPN
fnp-6316	51	11	,	,	PUNCT
fnp-6316	51	12	the	the	DET
fnp-6316	51	13	metastatic	metastatic	ADJ
fnp-6316	51	14	ways	way	NOUN
fnp-6316	51	15	of	of	ADP
fnp-6316	51	16	individual	individual	ADJ
fnp-6316	51	17	cancer	cancer	NOUN
fnp-6316	51	18	cells	cell	NOUN
fnp-6316	51	19	could	could	AUX
fnp-6316	51	20	be	be	AUX
fnp-6316	51	21	traced	trace	VERB
fnp-6316	51	22	over	over	ADP
fnp-6316	51	23	several	several	ADJ
fnp-6316	51	24	months	month	NOUN
fnp-6316	51	25	in	in	ADP
fnp-6316	51	26	a	a	DET
fnp-6316	51	27	murine	murine	ADJ
fnp-6316	51	28	model	model	NOUN
fnp-6316	51	29	with	with	ADP
fnp-6316	51	30	real	real	ADJ
fnp-6316	51	31	-	-	PUNCT
fnp-6316	51	32	time	time	NOUN
fnp-6316	51	33	multiphoton	multiphoton	NOUN
fnp-6316	51	34	laser	laser	NOUN
fnp-6316	51	35	scanning	scan	VERB
fnp-6316	51	36	microscopy	microscopy	NOUN
fnp-6316	51	37	[	[	X
fnp-6316	51	38	kienast	kienast	NOUN
fnp-6316	51	39	et	et	PROPN
fnp-6316	51	40	al	al	PROPN
fnp-6316	51	41	.	.	PROPN
fnp-6316	51	42	,	,	PUNCT
fnp-6316	51	43	2010	2010	NUM
fnp-6316	51	44	]	]	PUNCT
fnp-6316	51	45	.	.	PUNCT
fnp-6316	52	1	with	with	ADP
fnp-6316	52	2	this	this	PRON
fnp-6316	52	3	,	,	PUNCT
fnp-6316	52	4	the	the	DET
fnp-6316	52	5	authors	author	NOUN
fnp-6316	52	6	could	could	AUX
fnp-6316	52	7	identify	identify	VERB
fnp-6316	52	8	the	the	DET
fnp-6316	52	9	initial	initial	ADJ
fnp-6316	52	10	arrest	arrest	NOUN
fnp-6316	52	11	of	of	ADP
fnp-6316	52	12	cancer	cancer	NOUN
fnp-6316	52	13	cells	cell	NOUN
fnp-6316	52	14	at	at	ADP
fnp-6316	52	15	cerebral	cerebral	ADJ
fnp-6316	52	16	blood	blood	NOUN
fnp-6316	52	17	vessel	vessel	NOUN
fnp-6316	52	18	branches	branch	NOUN
fnp-6316	52	19	followed	follow	VERB
fnp-6316	52	20	by	by	ADP
fnp-6316	52	21	angiogenic	angiogenic	ADJ
fnp-6316	52	22	processes	process	NOUN
fnp-6316	52	23	or	or	CCONJ
fnp-6316	52	24	vessel	vessel	NOUN
fnp-6316	52	25	cooption	cooption	NOUN
fnp-6316	52	26	after	after	ADP
fnp-6316	52	27	early	early	ADJ
fnp-6316	52	28	extravasation	extravasation	NOUN
fnp-6316	52	29	.	.	PUNCT
fnp-6316	53	1	using	use	VERB
fnp-6316	53	2	a	a	DET
fnp-6316	53	3	similar	similar	ADJ
fnp-6316	53	4	methodological	methodological	ADJ
fnp-6316	53	5	approach	approach	NOUN
fnp-6316	53	6	,	,	PUNCT
fnp-6316	53	7	roesler	roesler	NOUN
fnp-6316	53	8	et	et	PROPN
fnp-6316	53	9	al	al	PROPN
fnp-6316	53	10	.	.	PROPN
fnp-6316	53	11	were	be	AUX
fnp-6316	53	12	now	now	ADV
fnp-6316	53	13	able	able	ADJ
fnp-6316	53	14	to	to	PART
fnp-6316	53	15	show	show	VERB
fnp-6316	53	16	a	a	DET
fnp-6316	53	17	similar	similar	ADJ
fnp-6316	53	18	intravascular	intravascular	ADJ
fnp-6316	53	19	tumor	tumor	NOUN
fnp-6316	53	20	cell	cell	NOUN
fnp-6316	53	21	arrest	arrest	NOUN
fnp-6316	53	22	in	in	ADP
fnp-6316	53	23	brain	brain	NOUN
fnp-6316	53	24	microvessels	microvessel	NOUN
fnp-6316	53	25	before	before	ADP
fnp-6316	53	26	extravasation	extravasation	NOUN
fnp-6316	53	27	and	and	CCONJ
fnp-6316	53	28	formation	formation	NOUN
fnp-6316	53	29	of	of	ADP
fnp-6316	53	30	micrometastases	micrometastase	NOUN
fnp-6316	54	1	[	[	X
fnp-6316	54	2	roesler	roesler	NOUN
fnp-6316	54	3	et	et	PROPN
fnp-6316	54	4	al	al	PROPN
fnp-6316	54	5	.	.	PROPN
fnp-6316	54	6	,	,	PUNCT
fnp-6316	54	7	2024	2024	NUM
fnp-6316	54	8	]	]	PUNCT
fnp-6316	54	9	.	.	PUNCT
fnp-6316	55	1	of	of	ADP
fnp-6316	55	2	note	note	NOUN
fnp-6316	55	3	,	,	PUNCT
fnp-6316	55	4	as	as	ADP
fnp-6316	55	5	a	a	DET
fnp-6316	55	6	most	most	ADV
fnp-6316	55	7	novel	novel	ADJ
fnp-6316	55	8	finding	finding	NOUN
fnp-6316	55	9	,	,	PUNCT
fnp-6316	55	10	already	already	ADV
fnp-6316	55	11	24h	24h	VERB
fnp-6316	55	12	after	after	ADP
fnp-6316	55	13	intracardiac	intracardiac	ADJ
fnp-6316	55	14	injection	injection	NOUN
fnp-6316	55	15	of	of	ADP
fnp-6316	55	16	tumor	tumor	NOUN
fnp-6316	55	17	cells	cell	NOUN
fnp-6316	55	18	,	,	PUNCT
fnp-6316	55	19	prominent	prominent	ADJ
fnp-6316	55	20	hypoxic	hypoxic	ADJ
fnp-6316	55	21	-	-	PUNCT
fnp-6316	55	22	ischemic	ischemic	ADJ
fnp-6316	55	23	tissue	tissue	NOUN
fnp-6316	55	24	alterations	alteration	NOUN
fnp-6316	55	25	were	be	AUX
fnp-6316	55	26	observed	observe	VERB
fnp-6316	55	27	in	in	ADP
fnp-6316	55	28	the	the	DET
fnp-6316	55	29	brain	brain	NOUN
fnp-6316	55	30	that	that	PRON
fnp-6316	55	31	were	be	AUX
fnp-6316	55	32	partly	partly	ADV
fnp-6316	55	33	well	well	ADV
fnp-6316	55	34	corresponding	corresponding	ADJ
fnp-6316	55	35	with	with	ADP
fnp-6316	55	36	areas	area	NOUN
fnp-6316	55	37	,	,	PUNCT
fnp-6316	55	38	in	in	ADP
fnp-6316	55	39	which	which	PRON
fnp-6316	55	40	metastasis	metastasis	NOUN
fnp-6316	55	41	formation	formation	NOUN
fnp-6316	55	42	was	be	AUX
fnp-6316	55	43	detected	detect	VERB
fnp-6316	55	44	at	at	ADP
fnp-6316	55	45	a	a	DET
fnp-6316	55	46	later	later	ADJ
fnp-6316	55	47	timepoint	timepoint	NOUN
fnp-6316	55	48	.	.	PUNCT
fnp-6316	56	1	in	in	ADP
fnp-6316	56	2	the	the	DET
fnp-6316	56	3	hypoxic	hypoxic	ADJ
fnp-6316	56	4	-	-	PUNCT
fnp-6316	56	5	ischemic	ischemic	ADJ
fnp-6316	56	6	areas	area	NOUN
fnp-6316	56	7	,	,	PUNCT
fnp-6316	56	8	an	an	DET
fnp-6316	56	9	upregulation	upregulation	NOUN
fnp-6316	56	10	of	of	ADP
fnp-6316	56	11	ang-2	ang-2	ADP
fnp-6316	56	12	,	,	PUNCT
fnp-6316	56	13	mmp9	mmp9	PROPN
fnp-6316	56	14	and	and	CCONJ
fnp-6316	56	15	vegf	vegf	PROPN
fnp-6316	56	16	was	be	AUX
fnp-6316	56	17	observed	observe	VERB
fnp-6316	56	18	in	in	ADP
fnp-6316	56	19	brain	brain	NOUN
fnp-6316	56	20	endothelial	endothelial	ADJ
fnp-6316	56	21	cells	cell	NOUN
fnp-6316	56	22	leading	lead	VERB
fnp-6316	56	23	to	to	ADP
fnp-6316	56	24	the	the	DET
fnp-6316	56	25	hypothesis	hypothesis	NOUN
fnp-6316	56	26	that	that	SCONJ
fnp-6316	56	27	those	those	DET
fnp-6316	56	28	hypoxiaassociated	hypoxiaassociated	ADJ
fnp-6316	56	29	molecules	molecule	NOUN
fnp-6316	56	30	might	might	AUX
fnp-6316	56	31	be	be	AUX
fnp-6316	56	32	at	at	ADV
fnp-6316	56	33	least	least	ADJ
fnp-6316	56	34	partly	partly	ADV
fnp-6316	56	35	responsible	responsible	ADJ
fnp-6316	56	36	for	for	ADP
fnp-6316	56	37	the	the	DET
fnp-6316	56	38	seeding	seeding	NOUN
fnp-6316	56	39	of	of	ADP
fnp-6316	56	40	metastatic	metastatic	ADJ
fnp-6316	56	41	cells	cell	NOUN
fnp-6316	56	42	in	in	ADP
fnp-6316	56	43	the	the	DET
fnp-6316	56	44	brain	brain	NOUN
fnp-6316	56	45	.	.	PUNCT
fnp-6316	57	1	to	to	PART
fnp-6316	57	2	corroborate	corroborate	VERB
fnp-6316	57	3	this	this	DET
fnp-6316	57	4	hypothesis	hypothesis	NOUN
fnp-6316	57	5	,	,	PUNCT
fnp-6316	57	6	the	the	DET
fnp-6316	57	7	authors	author	NOUN
fnp-6316	57	8	also	also	ADV
fnp-6316	57	9	used	use	VERB
fnp-6316	57	10	a	a	DET
fnp-6316	57	11	transgenic	transgenic	NOUN
fnp-6316	57	12	,	,	PUNCT
fnp-6316	57	13	endothelial	endothelial	NOUN
fnp-6316	57	14	-	-	PUNCT
fnp-6316	57	15	specific	specific	ADJ
fnp-6316	57	16	ang-2	ang-2	NOUN
fnp-6316	57	17	gain	gain	NOUN
fnp-6316	57	18	-	-	PUNCT
fnp-6316	57	19	of	of	ADP
fnp-6316	57	20	-	-	PUNCT
fnp-6316	57	21	function	function	NOUN
fnp-6316	57	22	approach	approach	NOUN
fnp-6316	57	23	that	that	PRON
fnp-6316	57	24	revealed	reveal	VERB
fnp-6316	57	25	an	an	DET
fnp-6316	57	26	increase	increase	NOUN
fnp-6316	57	27	of	of	ADP
fnp-6316	57	28	numbers	number	NOUN
fnp-6316	57	29	and	and	CCONJ
fnp-6316	57	30	volumes	volume	NOUN
fnp-6316	57	31	of	of	ADP
fnp-6316	57	32	brain	brain	NOUN
fnp-6316	57	33	metastases	metastasis	NOUN
fnp-6316	57	34	compared	compare	VERB
fnp-6316	57	35	to	to	ADP
fnp-6316	57	36	wild	wild	ADJ
fnp-6316	57	37	-	-	PUNCT
fnp-6316	57	38	type	type	NOUN
fnp-6316	57	39	animals	animal	NOUN
fnp-6316	57	40	thereby	thereby	ADV
fnp-6316	57	41	indicating	indicate	VERB
fnp-6316	57	42	that	that	SCONJ
fnp-6316	57	43	extravasation	extravasation	NOUN
fnp-6316	57	44	of	of	ADP
fnp-6316	57	45	cancer	cancer	NOUN
fnp-6316	57	46	cells	cell	NOUN
fnp-6316	57	47	into	into	ADP
fnp-6316	57	48	the	the	DET
fnp-6316	57	49	brain	brain	NOUN
fnp-6316	57	50	parenchyma	parenchyma	NOUN
fnp-6316	57	51	is	be	AUX
fnp-6316	57	52	ang-2	ang-2	ADV
fnp-6316	57	53	dependent	dependent	ADJ
fnp-6316	57	54	.	.	PUNCT
fnp-6316	58	1	the	the	DET
fnp-6316	58	2	findings	finding	NOUN
fnp-6316	58	3	of	of	ADP
fnp-6316	58	4	the	the	DET
fnp-6316	58	5	study	study	NOUN
fnp-6316	58	6	were	be	AUX
fnp-6316	58	7	in	in	ADP
fnp-6316	58	8	line	line	NOUN
fnp-6316	58	9	with	with	ADP
fnp-6316	58	10	previous	previous	ADJ
fnp-6316	58	11	findings	finding	NOUN
fnp-6316	58	12	showing	show	VERB
fnp-6316	58	13	that	that	SCONJ
fnp-6316	58	14	ang-2	ang-2	VERB
fnp-6316	58	15	expression	expression	NOUN
fnp-6316	58	16	correlated	correlate	VERB
fnp-6316	58	17	with	with	ADP
fnp-6316	58	18	bbb	bbb	PROPN
fnp-6316	58	19	disruption	disruption	NOUN
fnp-6316	58	20	,	,	PUNCT
fnp-6316	58	21	impaired	impair	VERB
fnp-6316	58	22	tight	tight	ADJ
fnp-6316	58	23	junctions	junction	NOUN
fnp-6316	58	24	and	and	CCONJ
fnp-6316	58	25	increased	increase	VERB
fnp-6316	58	26	blood	blood	NOUN
fnp-6316	58	27	vessel	vessel	NOUN
fnp-6316	58	28	permeability	permeability	NOUN
fnp-6316	58	29	in	in	ADP
fnp-6316	58	30	a	a	DET
fnp-6316	58	31	murine	murine	ADJ
fnp-6316	58	32	triple	triple	ADJ
fnp-6316	58	33	-	-	PUNCT
fnp-6316	58	34	negative	negative	ADJ
fnp-6316	58	35	breast	breast	NOUN
fnp-6316	58	36	cancer	cancer	NOUN
fnp-6316	58	37	model	model	NOUN
fnp-6316	59	1	[	[	X
fnp-6316	59	2	avraham	avraham	X
fnp-6316	59	3	et	et	PROPN
fnp-6316	59	4	al	al	PROPN
fnp-6316	59	5	.	.	PROPN
fnp-6316	59	6	,	,	PUNCT
fnp-6316	59	7	2014	2014	NUM
fnp-6316	59	8	]	]	PUNCT
fnp-6316	59	9	.	.	PUNCT
fnp-6316	60	1	the	the	DET
fnp-6316	60	2	findings	finding	NOUN
fnp-6316	60	3	of	of	ADP
fnp-6316	60	4	roesler	roesler	NOUN
fnp-6316	60	5	et	et	PROPN
fnp-6316	60	6	al	al	PROPN
fnp-6316	60	7	.	.	PROPN
fnp-6316	60	8	indicate	indicate	VERB
fnp-6316	60	9	that	that	PRON
fnp-6316	60	10	ang-2	ang-2	PUNCT
fnp-6316	60	11	and	and	CCONJ
fnp-6316	60	12	vegf	vegf	PROPN
fnp-6316	60	13	are	be	AUX
fnp-6316	60	14	crucial	crucial	ADJ
fnp-6316	60	15	for	for	ADP
fnp-6316	60	16	the	the	DET
fnp-6316	60	17	formation	formation	NOUN
fnp-6316	60	18	of	of	ADP
fnp-6316	60	19	brain	brain	NOUN
fnp-6316	60	20	metastases	metastasis	NOUN
fnp-6316	60	21	via	via	ADP
fnp-6316	60	22	shaping	shape	VERB
fnp-6316	60	23	a	a	DET
fnp-6316	60	24	tumor	tumor	NOUN
fnp-6316	60	25	-	-	PUNCT
fnp-6316	60	26	supporting	support	VERB
fnp-6316	60	27	pre	pre	ADJ
fnp-6316	60	28	-	-	ADJ
fnp-6316	60	29	metastatic	metastatic	ADJ
fnp-6316	60	30	niche	niche	NOUN
fnp-6316	60	31	,	,	PUNCT
fnp-6316	60	32	therefore	therefore	ADV
fnp-6316	60	33	being	be	AUX
fnp-6316	60	34	potential	potential	ADJ
fnp-6316	60	35	treatment	treatment	NOUN
fnp-6316	60	36	targets	target	NOUN
fnp-6316	60	37	,	,	PUNCT
fnp-6316	60	38	especially	especially	ADV
fnp-6316	60	39	in	in	ADP
fnp-6316	60	40	an	an	DET
fnp-6316	60	41	early	early	ADJ
fnp-6316	60	42	phase	phase	NOUN
fnp-6316	60	43	.	.	PUNCT
fnp-6316	61	1	with	with	ADP
fnp-6316	61	2	a	a	DET
fnp-6316	61	3	novel	novel	NOUN
fnp-6316	61	4	,	,	PUNCT
fnp-6316	61	5	early	early	ADJ
fnp-6316	61	6	pre	pre	ADJ
fnp-6316	61	7	-	-	ADJ
fnp-6316	61	8	metastatic	metastatic	ADJ
fnp-6316	61	9	inhibition	inhibition	NOUN
fnp-6316	61	10	of	of	ADP
fnp-6316	61	11	ang-2	ang-2	PUNCT
fnp-6316	61	12	(	(	PUNCT
fnp-6316	61	13	via	via	ADP
fnp-6316	61	14	the	the	DET
fnp-6316	61	15	amg	amg	PROPN
fnp-6316	61	16	386	386	NUM
fnp-6316	61	17	peptibody	peptibody	NOUN
fnp-6316	61	18	)	)	PUNCT
fnp-6316	61	19	and/or	and/or	CCONJ
fnp-6316	61	20	vegf	vegf	PROPN
fnp-6316	61	21	(	(	PUNCT
fnp-6316	61	22	via	via	ADP
fnp-6316	61	23	aflibercept	aflibercept	NOUN
fnp-6316	61	24	,	,	PUNCT
fnp-6316	61	25	a	a	DET
fnp-6316	61	26	fusion	fusion	NOUN
fnp-6316	61	27	protein	protein	NOUN
fnp-6316	61	28	with	with	ADP
fnp-6316	61	29	vegfr1	vegfr1	NOUN
fnp-6316	61	30	and	and	CCONJ
fnp-6316	61	31	vegfr2	vegfr2	NOUN
fnp-6316	61	32	domains	domain	NOUN
fnp-6316	61	33	serving	serve	VERB
fnp-6316	61	34	as	as	ADP
fnp-6316	61	35	a	a	DET
fnp-6316	61	36	so	so	ADV
fnp-6316	61	37	-	-	PUNCT
fnp-6316	61	38	called	call	VERB
fnp-6316	61	39	“	"	PUNCT
fnp-6316	61	40	vegf	vegf	PROPN
fnp-6316	61	41	trap	trap	NOUN
fnp-6316	61	42	”	"	PUNCT
fnp-6316	61	43	)	)	PUNCT
fnp-6316	61	44	,	,	PUNCT
fnp-6316	61	45	the	the	DET
fnp-6316	61	46	metastatic	metastatic	ADJ
fnp-6316	61	47	cerebral	cerebral	ADJ
fnp-6316	61	48	tumor	tumor	NOUN
fnp-6316	61	49	cell	cell	NOUN
fnp-6316	61	50	load	load	NOUN
fnp-6316	61	51	could	could	AUX
fnp-6316	61	52	be	be	AUX
fnp-6316	61	53	considerably	considerably	ADV
fnp-6316	61	54	reduced	reduce	VERB
fnp-6316	61	55	(	(	PUNCT
fnp-6316	61	56	see	see	VERB
fnp-6316	61	57	figure	figure	NOUN
fnp-6316	61	58	 	 	SPACE
fnp-6316	61	59	1	1	NUM
fnp-6316	61	60	)	)	PUNCT
fnp-6316	61	61	.	.	PUNCT
fnp-6316	62	1	similar	similar	ADJ
fnp-6316	62	2	findings	finding	NOUN
fnp-6316	62	3	were	be	AUX
fnp-6316	62	4	obtained	obtain	VERB
fnp-6316	62	5	in	in	ADP
fnp-6316	62	6	other	other	ADJ
fnp-6316	62	7	previous	previous	ADJ
fnp-6316	62	8	murine	murine	ADJ
fnp-6316	62	9	brain	brain	NOUN
fnp-6316	62	10	metastasis	metastasis	NOUN
fnp-6316	62	11	models	model	NOUN
fnp-6316	62	12	in	in	ADP
fnp-6316	62	13	which	which	PRON
fnp-6316	62	14	a	a	DET
fnp-6316	62	15	combined	combined	ADJ
fnp-6316	62	16	inhibition	inhibition	NOUN
fnp-6316	62	17	of	of	ADP
fnp-6316	62	18	ang-2	ang-2	PUNCT
fnp-6316	62	19	and	and	CCONJ
fnp-6316	62	20	vegf	vegf	PROPN
fnp-6316	62	21	reduced	reduce	VERB
fnp-6316	62	22	the	the	DET
fnp-6316	62	23	number	number	NOUN
fnp-6316	62	24	and	and	CCONJ
fnp-6316	62	25	volume	volume	NOUN
fnp-6316	62	26	of	of	ADP
fnp-6316	62	27	brain	brain	NOUN
fnp-6316	62	28	metastases	metastasis	NOUN
fnp-6316	62	29	while	while	SCONJ
fnp-6316	62	30	extracranial	extracranial	ADJ
fnp-6316	62	31	metastases	metastasis	NOUN
fnp-6316	62	32	did	do	AUX
fnp-6316	62	33	not	not	PART
fnp-6316	62	34	show	show	VERB
fnp-6316	62	35	a	a	DET
fnp-6316	62	36	positive	positive	ADJ
fnp-6316	62	37	treatment	treatment	NOUN
fnp-6316	62	38	response	response	NOUN
fnp-6316	63	1	[	[	X
fnp-6316	63	2	bohn	bohn	NOUN
fnp-6316	63	3	et	et	PROPN
fnp-6316	63	4	al	al	PROPN
fnp-6316	63	5	.	.	PROPN
fnp-6316	63	6	,	,	PUNCT
fnp-6316	63	7	2017	2017	NUM
fnp-6316	63	8	;	;	PUNCT
fnp-6316	63	9	kovalchuk	kovalchuk	PROPN
fnp-6316	63	10	et	et	PROPN
fnp-6316	63	11	al	al	PROPN
fnp-6316	63	12	.	.	PROPN
fnp-6316	63	13	,	,	PUNCT
fnp-6316	63	14	2020	2020	NUM
fnp-6316	63	15	]	]	PUNCT
fnp-6316	63	16	.	.	PUNCT
fnp-6316	64	1	in	in	ADP
fnp-6316	64	2	summary	summary	NOUN
fnp-6316	64	3	,	,	PUNCT
fnp-6316	64	4	roesler	roesler	NOUN
fnp-6316	64	5	et	et	PROPN
fnp-6316	64	6	al	al	PROPN
fnp-6316	64	7	.	.	PROPN
fnp-6316	64	8	present	present	VERB
fnp-6316	64	9	a	a	DET
fnp-6316	64	10	novel	novel	ADJ
fnp-6316	64	11	mechanism	mechanism	NOUN
fnp-6316	64	12	for	for	ADP
fnp-6316	64	13	brain	brain	NOUN
fnp-6316	64	14	metastatic	metastatic	NOUN
fnp-6316	64	15	processes	process	NOUN
fnp-6316	64	16	linked	link	VERB
fnp-6316	64	17	to	to	ADP
fnp-6316	64	18	an	an	DET
fnp-6316	64	19	increase	increase	NOUN
fnp-6316	64	20	of	of	ADP
fnp-6316	64	21	ang-2	ang-2	PUNCT
fnp-6316	64	22	and	and	CCONJ
fnp-6316	64	23	vegf	vegf	PROPN
fnp-6316	64	24	in	in	ADP
fnp-6316	64	25	the	the	DET
fnp-6316	64	26	cerebral	cerebral	ADJ
fnp-6316	64	27	pre	pre	ADJ
fnp-6316	64	28	-	-	ADJ
fnp-6316	64	29	metastatic	metastatic	ADJ
fnp-6316	64	30	niche	niche	NOUN
fnp-6316	64	31	which	which	PRON
fnp-6316	64	32	are	be	AUX
fnp-6316	64	33	induced	induce	VERB
fnp-6316	64	34	by	by	ADP
fnp-6316	64	35	focal	focal	ADJ
fnp-6316	64	36	hypoxic	hypoxic	ADJ
fnp-6316	64	37	-	-	PUNCT
fnp-6316	64	38	ischemic	ischemic	ADJ
fnp-6316	64	39	events	event	NOUN
fnp-6316	64	40	most	most	ADV
fnp-6316	64	41	probably	probably	ADV
fnp-6316	64	42	caused	cause	VERB
fnp-6316	64	43	by	by	ADP
fnp-6316	64	44	occlusion	occlusion	NOUN
fnp-6316	64	45	of	of	ADP
fnp-6316	64	46	brain	brain	NOUN
fnp-6316	64	47	capillaries	capillary	NOUN
fnp-6316	64	48	by	by	ADP
fnp-6316	64	49	tumor	tumor	NOUN
fnp-6316	64	50	cells	cell	NOUN
fnp-6316	64	51	.	.	PUNCT
fnp-6316	65	1	showing	show	VERB
fnp-6316	65	2	a	a	DET
fnp-6316	65	3	significantly	significantly	ADV
fnp-6316	65	4	reduced	reduce	VERB
fnp-6316	65	5	cerebral	cerebral	ADJ
fnp-6316	65	6	tumor	tumor	NOUN
fnp-6316	65	7	cell	cell	NOUN
fnp-6316	65	8	load	load	NOUN
fnp-6316	65	9	by	by	ADP
fnp-6316	65	10	early	early	ADJ
fnp-6316	65	11	dual	dual	ADJ
fnp-6316	65	12	inhibition	inhibition	NOUN
fnp-6316	65	13	of	of	ADP
fnp-6316	65	14	ang-2	ang-2	PUNCT
fnp-6316	65	15	and	and	CCONJ
fnp-6316	65	16	vegf	vegf	PROPN
fnp-6316	65	17	,	,	PUNCT
fnp-6316	65	18	this	this	DET
fnp-6316	65	19	treatment	treatment	NOUN
fnp-6316	65	20	approach	approach	NOUN
fnp-6316	65	21	could	could	AUX
fnp-6316	65	22	be	be	AUX
fnp-6316	65	23	highly	highly	ADV
fnp-6316	65	24	promising	promising	ADJ
fnp-6316	65	25	as	as	ADP
fnp-6316	65	26	a	a	DET
fnp-6316	65	27	prevention	prevention	NOUN
fnp-6316	65	28	strategy	strategy	NOUN
fnp-6316	65	29	in	in	ADP
fnp-6316	65	30	patients	patient	NOUN
fnp-6316	65	31	suffering	suffer	VERB
fnp-6316	65	32	from	from	ADP
fnp-6316	65	33	highly	highly	ADV
fnp-6316	65	34	malignant	malignant	ADJ
fnp-6316	65	35	tumors	tumor	NOUN
fnp-6316	65	36	with	with	ADP
fnp-6316	65	37	a	a	DET
fnp-6316	65	38	high	high	ADJ
fnp-6316	65	39	risk	risk	NOUN
fnp-6316	65	40	to	to	PART
fnp-6316	65	41	develop	develop	VERB
fnp-6316	65	42	cerebral	cerebral	ADJ
fnp-6316	65	43	metastases	metastasis	NOUN
fnp-6316	65	44	.	.	PUNCT
fnp-6316	66	1	2	2	X
fnp-6316	66	2	.	.	X
fnp-6316	66	3	global	global	ADJ
fnp-6316	66	4	dna	dna	PROPN
fnp-6316	66	5	methylation	methylation	NOUN
fnp-6316	66	6	as	as	ADP
fnp-6316	66	7	independent	independent	ADJ
fnp-6316	66	8	diagnostic	diagnostic	ADJ
fnp-6316	66	9	marker	marker	NOUN
fnp-6316	66	10	in	in	ADP
fnp-6316	66	11	idhwildtype	idhwildtype	NOUN
fnp-6316	66	12	glioblastoma	glioblastoma	NOUN
fnp-6316	67	1	[	[	X
fnp-6316	67	2	eckhardt	eckhardt	NOUN
fnp-6316	67	3	et	et	PROPN
fnp-6316	67	4	al	al	PROPN
fnp-6316	67	5	.	.	PROPN
fnp-6316	67	6	,	,	PUNCT
fnp-6316	67	7	2024	2024	NUM
fnp-6316	67	8	]	]	PUNCT
fnp-6316	68	1	large	large	ADJ
fnp-6316	68	2	population	population	NOUN
fnp-6316	68	3	-	-	PUNCT
fnp-6316	68	4	based	base	VERB
fnp-6316	68	5	studies	study	NOUN
fnp-6316	68	6	still	still	ADV
fnp-6316	68	7	report	report	VERB
fnp-6316	68	8	median	median	ADJ
fnp-6316	68	9	survival	survival	NOUN
fnp-6316	68	10	times	time	NOUN
fnp-6316	68	11	of	of	ADP
fnp-6316	68	12	slightly	slightly	ADV
fnp-6316	68	13	more	more	ADJ
fnp-6316	68	14	than	than	ADP
fnp-6316	68	15	6	6	NUM
fnp-6316	68	16	months	month	NOUN
fnp-6316	68	17	for	for	ADP
fnp-6316	68	18	glioblastoma	glioblastoma	NOUN
fnp-6316	68	19	patients	patient	NOUN
fnp-6316	68	20	that	that	PRON
fnp-6316	68	21	could	could	AUX
fnp-6316	68	22	be	be	AUX
fnp-6316	68	23	considerably	considerably	ADV
fnp-6316	68	24	increased	increase	VERB
fnp-6316	68	25	to	to	ADP
fnp-6316	68	26	a	a	DET
fnp-6316	68	27	median	median	NOUN
fnp-6316	68	28	of	of	ADP
fnp-6316	68	29	14.8	14.8	NUM
fnp-6316	68	30	months	month	NOUN
fnp-6316	68	31	in	in	ADP
fnp-6316	68	32	cases	case	NOUN
fnp-6316	68	33	with	with	ADP
fnp-6316	68	34	maximum	maximum	ADJ
fnp-6316	68	35	treatment	treatment	NOUN
fnp-6316	68	36	including	include	VERB
fnp-6316	68	37	neurosurgical	neurosurgical	ADJ
fnp-6316	68	38	resection	resection	NOUN
fnp-6316	68	39	followed	follow	VERB
fnp-6316	68	40	by	by	ADP
fnp-6316	68	41	radiochemotherapy	radiochemotherapy	NOUN
fnp-6316	68	42	[	[	X
fnp-6316	68	43	brodbelt	brodbelt	NOUN
fnp-6316	68	44	et	et	PROPN
fnp-6316	68	45	al	al	PROPN
fnp-6316	68	46	.	.	PROPN
fnp-6316	68	47	,	,	PUNCT
fnp-6316	68	48	2015	2015	NUM
fnp-6316	68	49	]	]	PUNCT
fnp-6316	68	50	.	.	PUNCT
fnp-6316	69	1	of	of	ADP
fnp-6316	69	2	note	note	NOUN
fnp-6316	69	3	,	,	PUNCT
fnp-6316	69	4	approximately	approximately	ADV
fnp-6316	69	5	30	30	NUM
fnp-6316	69	6	 	 	SPACE
fnp-6316	69	7	%	%	NOUN
fnp-6316	69	8	of	of	ADP
fnp-6316	69	9	all	all	DET
fnp-6316	69	10	glioblastoma	glioblastoma	NOUN
fnp-6316	69	11	patients	patient	NOUN
fnp-6316	69	12	survive	survive	VERB
fnp-6316	69	13	2	2	NUM
fnp-6316	69	14	years	year	NOUN
fnp-6316	69	15	or	or	CCONJ
fnp-6316	69	16	longer	long	ADV
fnp-6316	69	17	after	after	ADP
fnp-6316	69	18	initial	initial	ADJ
fnp-6316	69	19	diagnosis	diagnosis	NOUN
fnp-6316	69	20	.	.	PUNCT
fnp-6316	70	1	apart	apart	ADV
fnp-6316	70	2	from	from	ADP
fnp-6316	70	3	age	age	NOUN
fnp-6316	70	4	,	,	PUNCT
fnp-6316	70	5	mgmt	mgmt	NOUN
fnp-6316	70	6	promoter	promoter	NOUN
fnp-6316	70	7	methylation	methylation	NOUN
fnp-6316	70	8	,	,	PUNCT
fnp-6316	70	9	extent	extent	NOUN
fnp-6316	70	10	of	of	ADP
fnp-6316	70	11	resection	resection	NOUN
fnp-6316	70	12	and	and	CCONJ
fnp-6316	70	13	followup	followup	ADJ
fnp-6316	70	14	treatment	treatment	NOUN
fnp-6316	70	15	,	,	PUNCT
fnp-6316	70	16	there	there	PRON
fnp-6316	70	17	is	be	VERB
fnp-6316	70	18	not	not	PART
fnp-6316	70	19	much	much	ADV
fnp-6316	70	20	known	know	VERB
fnp-6316	70	21	about	about	ADP
fnp-6316	70	22	glioblastoma	glioblastoma	NOUN
fnp-6316	70	23	-	-	PUNCT
fnp-6316	70	24	intrinsic	intrinsic	ADJ
fnp-6316	70	25	tumor	tumor	NOUN
fnp-6316	70	26	biological	biological	ADJ
fnp-6316	70	27	factors	factor	NOUN
fnp-6316	70	28	that	that	PRON
fnp-6316	70	29	might	might	AUX
fnp-6316	70	30	well	well	ADV
fnp-6316	70	31	predict	predict	VERB
fnp-6316	70	32	patient	patient	ADJ
fnp-6316	70	33	prognosis	prognosis	NOUN
fnp-6316	70	34	.	.	PUNCT
fnp-6316	71	1	nowadays	nowadays	ADV
fnp-6316	71	2	,	,	PUNCT
fnp-6316	71	3	neuropathological	neuropathological	ADJ
fnp-6316	71	4	diagnostics	diagnostic	NOUN
fnp-6316	71	5	in	in	ADP
fnp-6316	71	6	the	the	DET
fnp-6316	71	7	field	field	NOUN
fnp-6316	71	8	of	of	ADP
fnp-6316	71	9	neuro	neuro	PROPN
fnp-6316	71	10	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	71	11	free	free	ADJ
fnp-6316	71	12	neuropathology	neuropathology	NOUN
fnp-6316	71	13	6:10	6:10	NUM
fnp-6316	71	14	(	(	PUNCT
fnp-6316	71	15	2025	2025	NUM
fnp-6316	71	16	)	)	PUNCT
fnp-6316	71	17	michel	michel	PROPN
fnp-6316	71	18	mittelbronn	mittelbronn	PROPN
fnp-6316	71	19	doi	doi	PROPN
fnp-6316	71	20	:	:	PUNCT
fnp-6316	71	21	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	71	22	page	page	NOUN
fnp-6316	71	23	4	4	NUM
fnp-6316	71	24	of	of	ADP
fnp-6316	71	25	19	19	NUM
fnp-6316	71	26	figure	figure	NOUN
fnp-6316	71	27	 	 	SPACE
fnp-6316	71	28	1	1	NUM
fnp-6316	71	29	:	:	PUNCT
fnp-6316	71	30	concept	concept	NOUN
fnp-6316	71	31	of	of	ADP
fnp-6316	71	32	brain	brain	NOUN
fnp-6316	71	33	metastasis	metastasis	NOUN
fnp-6316	71	34	formation	formation	NOUN
fnp-6316	71	35	and	and	CCONJ
fnp-6316	71	36	therapeutic	therapeutic	ADJ
fnp-6316	71	37	prevention	prevention	NOUN
fnp-6316	71	38	oncology	oncology	NOUN
fnp-6316	71	39	is	be	AUX
fnp-6316	71	40	most	most	ADV
fnp-6316	71	41	precisely	precisely	ADV
fnp-6316	71	42	performed	perform	VERB
fnp-6316	71	43	by	by	ADP
fnp-6316	71	44	dna	dna	PROPN
fnp-6316	71	45	methylation	methylation	NOUN
fnp-6316	71	46	profiling	profiling	NOUN
fnp-6316	72	1	[	[	X
fnp-6316	72	2	capper	capper	NOUN
fnp-6316	72	3	et	et	NOUN
fnp-6316	72	4	al	al	PROPN
fnp-6316	72	5	.	.	PROPN
fnp-6316	72	6	,	,	PUNCT
fnp-6316	72	7	2018	2018	NUM
fnp-6316	72	8	]	]	PUNCT
fnp-6316	72	9	.	.	PUNCT
fnp-6316	73	1	within	within	ADP
fnp-6316	73	2	the	the	DET
fnp-6316	73	3	class	class	NOUN
fnp-6316	73	4	of	of	ADP
fnp-6316	73	5	idh	idh	PROPN
fnp-6316	73	6	wildtype	wildtype	NOUN
fnp-6316	73	7	glioblastoma	glioblastoma	NOUN
fnp-6316	73	8	,	,	PUNCT
fnp-6316	73	9	mainly	mainly	ADV
fnp-6316	73	10	3	3	NUM
fnp-6316	73	11	subclasses	subclass	NOUN
fnp-6316	73	12	could	could	AUX
fnp-6316	73	13	be	be	AUX
fnp-6316	73	14	defined	define	VERB
fnp-6316	73	15	:	:	PUNCT
fnp-6316	73	16	receptor	receptor	NOUN
fnp-6316	73	17	tyrosine	tyrosine	NOUN
fnp-6316	73	18	kinase	kinase	PROPN
fnp-6316	74	1	i	i	PRON
fnp-6316	74	2	(	(	PUNCT
fnp-6316	74	3	rtk	rtk	PROPN
fnp-6316	74	4	i	i	PROPN
fnp-6316	74	5	)	)	PUNCT
fnp-6316	74	6	,	,	PUNCT
fnp-6316	74	7	rtk	rtk	PROPN
fnp-6316	74	8	ii	ii	PROPN
fnp-6316	74	9	and	and	CCONJ
fnp-6316	74	10	mesenchymal	mesenchymal	PROPN
fnp-6316	74	11	subclass	subclass	NOUN
fnp-6316	74	12	,	,	PUNCT
fnp-6316	74	13	however	however	ADV
fnp-6316	74	14	without	without	ADP
fnp-6316	74	15	showing	show	VERB
fnp-6316	74	16	any	any	DET
fnp-6316	74	17	relevant	relevant	ADJ
fnp-6316	74	18	survival	survival	NOUN
fnp-6316	74	19	differences	difference	NOUN
fnp-6316	74	20	[	[	X
fnp-6316	74	21	drexler	drexler	NOUN
fnp-6316	74	22	et	et	PROPN
fnp-6316	74	23	al	al	PROPN
fnp-6316	74	24	.	.	PROPN
fnp-6316	74	25	,	,	PUNCT
fnp-6316	74	26	2023b	2023b	NUM
fnp-6316	74	27	]	]	PUNCT
fnp-6316	74	28	.	.	PUNCT
fnp-6316	75	1	in	in	ADP
fnp-6316	75	2	general	general	ADJ
fnp-6316	75	3	,	,	PUNCT
fnp-6316	75	4	only	only	ADJ
fnp-6316	75	5	poor	poor	ADJ
fnp-6316	75	6	data	datum	NOUN
fnp-6316	75	7	is	be	AUX
fnp-6316	75	8	available	available	ADJ
fnp-6316	75	9	about	about	ADP
fnp-6316	75	10	the	the	DET
fnp-6316	75	11	potential	potential	ADJ
fnp-6316	75	12	prognostic	prognostic	ADJ
fnp-6316	75	13	impact	impact	NOUN
fnp-6316	75	14	of	of	ADP
fnp-6316	75	15	methylation	methylation	NOUN
fnp-6316	75	16	differences	difference	NOUN
fnp-6316	75	17	within	within	ADP
fnp-6316	75	18	distinct	distinct	ADJ
fnp-6316	75	19	tumor	tumor	NOUN
fnp-6316	75	20	entities	entity	NOUN
fnp-6316	75	21	.	.	PUNCT
fnp-6316	76	1	to	to	PART
fnp-6316	76	2	address	address	VERB
fnp-6316	76	3	this	this	DET
fnp-6316	76	4	question	question	NOUN
fnp-6316	76	5	,	,	PUNCT
fnp-6316	76	6	eckhardt	eckhardt	PROPN
fnp-6316	76	7	et	et	PROPN
fnp-6316	76	8	al	al	PROPN
fnp-6316	76	9	.	.	PROPN
fnp-6316	76	10	assessed	assess	VERB
fnp-6316	76	11	492	492	NUM
fnp-6316	76	12	primary	primary	NOUN
fnp-6316	76	13	and	and	CCONJ
fnp-6316	76	14	31	31	NUM
fnp-6316	76	15	relapse	relapse	NOUN
fnp-6316	76	16	idh	idh	NOUN
fnp-6316	76	17	wildtype	wildtype	NOUN
fnp-6316	76	18	glioblastomas	glioblastoma	NOUN
fnp-6316	76	19	that	that	PRON
fnp-6316	76	20	all	all	PRON
fnp-6316	76	21	received	receive	VERB
fnp-6316	76	22	similar	similar	ADJ
fnp-6316	76	23	standard	standard	ADJ
fnp-6316	76	24	treatment	treatment	NOUN
fnp-6316	76	25	regimen	regiman	NOUN
fnp-6316	76	26	.	.	PUNCT
fnp-6316	77	1	although	although	SCONJ
fnp-6316	77	2	no	no	DET
fnp-6316	77	3	unequivocally	unequivocally	ADV
fnp-6316	77	4	clear	clear	ADJ
fnp-6316	77	5	methylation	methylation	NOUN
fnp-6316	77	6	signature	signature	NOUN
fnp-6316	77	7	associated	associate	VERB
fnp-6316	77	8	with	with	ADP
fnp-6316	77	9	patient	patient	ADJ
fnp-6316	77	10	survival	survival	NOUN
fnp-6316	77	11	could	could	AUX
fnp-6316	77	12	be	be	AUX
fnp-6316	77	13	detected	detect	VERB
fnp-6316	77	14	,	,	PUNCT
fnp-6316	77	15	the	the	DET
fnp-6316	77	16	median	median	ADJ
fnp-6316	77	17	methylation	methylation	NOUN
fnp-6316	77	18	rate	rate	NOUN
fnp-6316	77	19	of	of	ADP
fnp-6316	77	20	0.49	0.49	NUM
fnp-6316	77	21	significantly	significantly	ADV
fnp-6316	77	22	split	split	VERB
fnp-6316	77	23	the	the	DET
fnp-6316	77	24	cohort	cohort	NOUN
fnp-6316	77	25	in	in	ADP
fnp-6316	77	26	long	long	ADJ
fnp-6316	77	27	(	(	PUNCT
fnp-6316	77	28	median	median	ADJ
fnp-6316	77	29	methylation	methylation	NOUN
fnp-6316	77	30	above	above	ADP
fnp-6316	77	31	0.49	0.49	NUM
fnp-6316	77	32	;	;	PUNCT
fnp-6316	77	33	median	median	ADJ
fnp-6316	77	34	overall	overall	ADJ
fnp-6316	77	35	survival	survival	NOUN
fnp-6316	77	36	of	of	ADP
fnp-6316	77	37	18	18	NUM
fnp-6316	77	38	months	month	NOUN
fnp-6316	77	39	)	)	PUNCT
fnp-6316	77	40	and	and	CCONJ
fnp-6316	77	41	short	short	ADJ
fnp-6316	77	42	(	(	PUNCT
fnp-6316	77	43	median	median	ADJ
fnp-6316	77	44	methylation	methylation	NOUN
fnp-6316	77	45	level	level	NOUN
fnp-6316	77	46	equal	equal	ADJ
fnp-6316	77	47	or	or	CCONJ
fnp-6316	77	48	below	below	ADP
fnp-6316	77	49	0.49	0.49	NUM
fnp-6316	77	50	;	;	PUNCT
fnp-6316	77	51	median	median	ADJ
fnp-6316	77	52	survival	survival	NOUN
fnp-6316	77	53	of	of	ADP
fnp-6316	77	54	13	13	NUM
fnp-6316	77	55	months	month	NOUN
fnp-6316	77	56	)	)	PUNCT
fnp-6316	77	57	time	time	NOUN
fnp-6316	77	58	survivors	survivor	NOUN
fnp-6316	77	59	.	.	PUNCT
fnp-6316	78	1	the	the	DET
fnp-6316	78	2	optimal	optimal	ADJ
fnp-6316	78	3	cut	cut	NOUN
fnp-6316	78	4	-	-	PUNCT
fnp-6316	78	5	off	off	ADP
fnp-6316	78	6	level	level	NOUN
fnp-6316	78	7	was	be	AUX
fnp-6316	78	8	determined	determine	VERB
fnp-6316	78	9	as	as	ADP
fnp-6316	78	10	a	a	DET
fnp-6316	78	11	beta	beta	NOUN
fnp-6316	78	12	value	value	NOUN
fnp-6316	78	13	of	of	ADP
fnp-6316	78	14	0.458	0.458	NUM
fnp-6316	78	15	that	that	PRON
fnp-6316	78	16	allowed	allow	VERB
fnp-6316	78	17	for	for	ADP
fnp-6316	78	18	identifying	identify	VERB
fnp-6316	78	19	a	a	DET
fnp-6316	78	20	smaller	small	ADJ
fnp-6316	78	21	subgroup	subgroup	NOUN
fnp-6316	78	22	of	of	ADP
fnp-6316	78	23	73	73	NUM
fnp-6316	78	24	patients	patient	NOUN
fnp-6316	78	25	with	with	ADP
fnp-6316	78	26	a	a	DET
fnp-6316	78	27	median	median	ADJ
fnp-6316	78	28	overall	overall	ADJ
fnp-6316	78	29	survival	survival	NOUN
fnp-6316	78	30	of	of	ADP
fnp-6316	78	31	only	only	ADV
fnp-6316	78	32	9.2	9.2	NUM
fnp-6316	78	33	months	month	NOUN
fnp-6316	78	34	.	.	PUNCT
fnp-6316	79	1	of	of	ADP
fnp-6316	79	2	note	note	NOUN
fnp-6316	79	3	,	,	PUNCT
fnp-6316	79	4	the	the	DET
fnp-6316	79	5	mean	mean	ADJ
fnp-6316	79	6	methylation	methylation	NOUN
fnp-6316	79	7	level	level	NOUN
fnp-6316	79	8	was	be	AUX
fnp-6316	79	9	an	an	DET
fnp-6316	79	10	independent	independent	ADJ
fnp-6316	79	11	prognostic	prognostic	ADJ
fnp-6316	79	12	marker	marker	NOUN
fnp-6316	79	13	in	in	ADP
fnp-6316	79	14	a	a	DET
fnp-6316	79	15	multivariate	multivariate	NOUN
fnp-6316	79	16	analysis	analysis	NOUN
fnp-6316	79	17	together	together	ADV
fnp-6316	79	18	patient	patient	ADJ
fnp-6316	79	19	age	age	NOUN
fnp-6316	79	20	,	,	PUNCT
fnp-6316	79	21	mgmt	mgmt	NOUN
fnp-6316	79	22	promoter	promoter	NOUN
fnp-6316	79	23	methylation	methylation	NOUN
fnp-6316	79	24	status	status	NOUN
fnp-6316	79	25	and	and	CCONJ
fnp-6316	79	26	extent	extent	NOUN
fnp-6316	79	27	of	of	ADP
fnp-6316	79	28	resection	resection	NOUN
fnp-6316	79	29	,	,	PUNCT
fnp-6316	79	30	all	all	DET
fnp-6316	79	31	factors	factor	NOUN
fnp-6316	79	32	that	that	PRON
fnp-6316	79	33	are	be	AUX
fnp-6316	79	34	known	know	VERB
fnp-6316	79	35	as	as	ADP
fnp-6316	79	36	prognosticators	prognosticator	NOUN
fnp-6316	79	37	for	for	ADP
fnp-6316	79	38	a	a	DET
fnp-6316	79	39	long	long	ADJ
fnp-6316	79	40	time	time	NOUN
fnp-6316	79	41	.	.	PUNCT
fnp-6316	80	1	the	the	DET
fnp-6316	80	2	authors	author	NOUN
fnp-6316	80	3	further	far	ADV
fnp-6316	80	4	showed	show	VERB
fnp-6316	80	5	that	that	SCONJ
fnp-6316	80	6	rtk	rtk	PROPN
fnp-6316	80	7	i	i	PRON
fnp-6316	80	8	subclass	subclass	NOUN
fnp-6316	80	9	glioblastoma	glioblastoma	NOUN
fnp-6316	80	10	had	have	VERB
fnp-6316	80	11	the	the	DET
fnp-6316	80	12	worst	bad	ADJ
fnp-6316	80	13	median	median	ADJ
fnp-6316	80	14	survival	survival	NOUN
fnp-6316	80	15	reaching	reach	VERB
fnp-6316	80	16	14.2	14.2	NUM
fnp-6316	80	17	months	month	NOUN
fnp-6316	80	18	while	while	SCONJ
fnp-6316	80	19	displaying	display	VERB
fnp-6316	80	20	significantly	significantly	ADV
fnp-6316	80	21	lower	low	ADJ
fnp-6316	80	22	mean	mean	ADJ
fnp-6316	80	23	methylation	methylation	NOUN
fnp-6316	80	24	levels	level	NOUN
fnp-6316	80	25	compared	compare	VERB
fnp-6316	80	26	to	to	ADP
fnp-6316	80	27	its	its	PRON
fnp-6316	80	28	counterparts	counterpart	NOUN
fnp-6316	80	29	that	that	PRON
fnp-6316	80	30	reached	reach	VERB
fnp-6316	80	31	15	15	NUM
fnp-6316	80	32	months	month	NOUN
fnp-6316	80	33	(	(	PUNCT
fnp-6316	80	34	rtk	rtk	PROPN
fnp-6316	80	35	ii	ii	PROPN
fnp-6316	80	36	)	)	PUNCT
fnp-6316	80	37	and	and	CCONJ
fnp-6316	80	38	18.8	18.8	NUM
fnp-6316	80	39	months	month	NOUN
fnp-6316	80	40	(	(	PUNCT
fnp-6316	80	41	mesenchymal	mesenchymal	NOUN
fnp-6316	80	42	)	)	PUNCT
fnp-6316	80	43	.	.	PUNCT
fnp-6316	81	1	however	however	ADV
fnp-6316	81	2	,	,	PUNCT
fnp-6316	81	3	the	the	DET
fnp-6316	81	4	mean	mean	ADJ
fnp-6316	81	5	methylation	methylation	NOUN
fnp-6316	81	6	levels	level	NOUN
fnp-6316	81	7	were	be	AUX
fnp-6316	81	8	still	still	ADV
fnp-6316	81	9	significantly	significantly	ADV
fnp-6316	81	10	associated	associate	VERB
fnp-6316	81	11	in	in	ADP
fnp-6316	81	12	rtk	rtk	PROPN
fnp-6316	81	13	i	i	PROPN
fnp-6316	81	14	and	and	CCONJ
fnp-6316	81	15	ii	ii	PROPN
fnp-6316	81	16	subclasses	subclass	NOUN
fnp-6316	81	17	.	.	PUNCT
fnp-6316	82	1	combined	combine	VERB
fnp-6316	82	2	risk	risk	NOUN
fnp-6316	82	3	classes	class	NOUN
fnp-6316	82	4	including	include	VERB
fnp-6316	82	5	mean	mean	NOUN
fnp-6316	82	6	methylation	methylation	NOUN
fnp-6316	82	7	level	level	NOUN
fnp-6316	82	8	,	,	PUNCT
fnp-6316	82	9	age	age	NOUN
fnp-6316	82	10	,	,	PUNCT
fnp-6316	82	11	extent	extent	NOUN
fnp-6316	82	12	of	of	ADP
fnp-6316	82	13	resection	resection	NOUN
fnp-6316	82	14	and	and	CCONJ
fnp-6316	82	15	mgmt	mgmt	PROPN
fnp-6316	82	16	promoter	promoter	NOUN
fnp-6316	82	17	methylation	methylation	NOUN
fnp-6316	82	18	could	could	AUX
fnp-6316	82	19	further	far	ADV
fnp-6316	82	20	increase	increase	VERB
fnp-6316	82	21	the	the	DET
fnp-6316	82	22	prognostic	prognostic	ADJ
fnp-6316	82	23	prediction	prediction	NOUN
fnp-6316	82	24	by	by	ADP
fnp-6316	82	25	splitting	split	VERB
fnp-6316	82	26	the	the	DET
fnp-6316	82	27	cohort	cohort	NOUN
fnp-6316	82	28	into	into	ADP
fnp-6316	82	29	a	a	DET
fnp-6316	82	30	risk	risk	NOUN
fnp-6316	82	31	factor	factor	NOUN
fnp-6316	82	32	-	-	PUNCT
fnp-6316	82	33	free	free	ADJ
fnp-6316	82	34	subgroup	subgroup	NOUN
fnp-6316	82	35	reaching	reach	VERB
fnp-6316	82	36	39	39	NUM
fnp-6316	82	37	months	month	NOUN
fnp-6316	82	38	of	of	ADP
fnp-6316	82	39	median	median	ADJ
fnp-6316	82	40	survival	survival	NOUN
fnp-6316	82	41	while	while	SCONJ
fnp-6316	82	42	the	the	DET
fnp-6316	82	43	worst	bad	ADJ
fnp-6316	82	44	subgroup	subgroup	NOUN
fnp-6316	82	45	only	only	ADV
fnp-6316	82	46	reached	reach	VERB
fnp-6316	82	47	8.3	8.3	NUM
fnp-6316	82	48	months	month	NOUN
fnp-6316	82	49	(	(	PUNCT
fnp-6316	82	50	figure	figure	NOUN
fnp-6316	82	51	 	 	SPACE
fnp-6316	82	52	2	2	NUM
fnp-6316	82	53	)	)	PUNCT
fnp-6316	82	54	.	.	PUNCT
fnp-6316	83	1	while	while	SCONJ
fnp-6316	83	2	immune	immune	ADJ
fnp-6316	83	3	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	83	4	free	free	ADJ
fnp-6316	83	5	neuropathology	neuropathology	NOUN
fnp-6316	83	6	6:10	6:10	NUM
fnp-6316	83	7	(	(	PUNCT
fnp-6316	83	8	2025	2025	NUM
fnp-6316	83	9	)	)	PUNCT
fnp-6316	83	10	michel	michel	PROPN
fnp-6316	83	11	mittelbronn	mittelbronn	PROPN
fnp-6316	83	12	doi	doi	PROPN
fnp-6316	83	13	:	:	PUNCT
fnp-6316	83	14	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	83	15	page	page	NOUN
fnp-6316	83	16	5	5	NUM
fnp-6316	83	17	of	of	ADP
fnp-6316	83	18	19	19	NUM
fnp-6316	83	19	figure	figure	NOUN
fnp-6316	83	20	 	 	SPACE
fnp-6316	83	21	2	2	NUM
fnp-6316	83	22	:	:	PUNCT
fnp-6316	83	23	risk	risk	NOUN
fnp-6316	83	24	stratification	stratification	NOUN
fnp-6316	83	25	for	for	ADP
fnp-6316	83	26	idh	idh	PROPN
fnp-6316	83	27	wildtype	wildtype	NOUN
fnp-6316	83	28	glioblastoma	glioblastoma	NOUN
fnp-6316	83	29	patients	patient	NOUN
fnp-6316	83	30	.	.	PUNCT
fnp-6316	84	1	patient	patient	ADJ
fnp-6316	84	2	age	age	NOUN
fnp-6316	84	3	over	over	ADP
fnp-6316	84	4	65	65	NUM
fnp-6316	84	5	years	year	NOUN
fnp-6316	84	6	,	,	PUNCT
fnp-6316	84	7	extent	extent	NOUN
fnp-6316	84	8	of	of	ADP
fnp-6316	84	9	less	less	ADJ
fnp-6316	84	10	than	than	ADP
fnp-6316	84	11	90	90	NUM
fnp-6316	84	12	 	 	SPACE
fnp-6316	84	13	%	%	NOUN
fnp-6316	84	14	of	of	ADP
fnp-6316	84	15	the	the	DET
fnp-6316	84	16	contrastenhancing	contrastenhance	VERB
fnp-6316	84	17	tumor	tumor	NOUN
fnp-6316	84	18	area	area	NOUN
fnp-6316	84	19	,	,	PUNCT
fnp-6316	84	20	an	an	DET
fnp-6316	84	21	unmethylated	unmethylated	ADJ
fnp-6316	84	22	mgmt	mgmt	NOUN
fnp-6316	84	23	promoter	promoter	NOUN
fnp-6316	84	24	and	and	CCONJ
fnp-6316	84	25	a	a	DET
fnp-6316	84	26	low	low	ADJ
fnp-6316	84	27	mean	mean	ADJ
fnp-6316	84	28	global	global	ADJ
fnp-6316	84	29	methylation	methylation	NOUN
fnp-6316	84	30	beta	beta	NOUN
fnp-6316	84	31	value	value	NOUN
fnp-6316	84	32	of	of	ADP
fnp-6316	84	33	less	less	ADJ
fnp-6316	84	34	than	than	ADP
fnp-6316	84	35	0.49	0.49	NUM
fnp-6316	84	36	are	be	AUX
fnp-6316	84	37	considered	consider	VERB
fnp-6316	84	38	as	as	ADP
fnp-6316	84	39	negative	negative	ADJ
fnp-6316	84	40	prognostic	prognostic	ADJ
fnp-6316	84	41	factors	factor	NOUN
fnp-6316	84	42	.	.	PUNCT
fnp-6316	85	1	median	median	ADJ
fnp-6316	85	2	overall	overall	ADJ
fnp-6316	85	3	survival	survival	PROPN
fnp-6316	85	4	times	time	NOUN
fnp-6316	85	5	are	be	AUX
fnp-6316	85	6	as	as	SCONJ
fnp-6316	85	7	follows	follow	VERB
fnp-6316	85	8	:	:	PUNCT
fnp-6316	85	9	risk	risk	NOUN
fnp-6316	85	10	group	group	NOUN
fnp-6316	85	11	1	1	NUM
fnp-6316	85	12	:	:	SYM
fnp-6316	85	13	39	39	NUM
fnp-6316	85	14	months	month	NOUN
fnp-6316	85	15	;	;	PUNCT
fnp-6316	85	16	risk	risk	NOUN
fnp-6316	85	17	group	group	NOUN
fnp-6316	85	18	2	2	NUM
fnp-6316	85	19	:	:	SYM
fnp-6316	85	20	19	19	NUM
fnp-6316	85	21	months	month	NOUN
fnp-6316	85	22	;	;	PUNCT
fnp-6316	85	23	risk	risk	NOUN
fnp-6316	85	24	group	group	NOUN
fnp-6316	85	25	3	3	NUM
fnp-6316	85	26	:	:	SYM
fnp-6316	85	27	8.3	8.3	NUM
fnp-6316	85	28	months	month	NOUN
fnp-6316	85	29	.	.	PUNCT
fnp-6316	86	1	cell	cell	NOUN
fnp-6316	86	2	infiltration	infiltration	NOUN
fnp-6316	86	3	could	could	AUX
fnp-6316	86	4	be	be	AUX
fnp-6316	86	5	bioinformatically	bioinformatically	ADV
fnp-6316	86	6	ruled	rule	VERB
fnp-6316	86	7	out	out	ADP
fnp-6316	86	8	as	as	ADP
fnp-6316	86	9	underlying	underlying	ADJ
fnp-6316	86	10	explanatory	explanatory	ADJ
fnp-6316	86	11	factor	factor	NOUN
fnp-6316	86	12	,	,	PUNCT
fnp-6316	86	13	higher	high	ADJ
fnp-6316	86	14	mean	mean	NOUN
fnp-6316	86	15	methylation	methylation	NOUN
fnp-6316	86	16	levels	level	NOUN
fnp-6316	86	17	were	be	AUX
fnp-6316	86	18	associated	associate	VERB
fnp-6316	86	19	with	with	ADP
fnp-6316	86	20	better	well	ADJ
fnp-6316	86	21	radiosensitivity	radiosensitivity	NOUN
fnp-6316	86	22	,	,	PUNCT
fnp-6316	86	23	therefore	therefore	ADV
fnp-6316	86	24	at	at	ADP
fnp-6316	86	25	least	least	ADJ
fnp-6316	86	26	providing	provide	VERB
fnp-6316	86	27	a	a	DET
fnp-6316	86	28	hypothesis	hypothesis	NOUN
fnp-6316	86	29	why	why	SCONJ
fnp-6316	86	30	the	the	DET
fnp-6316	86	31	patient	patient	ADJ
fnp-6316	86	32	subgroup	subgroup	NOUN
fnp-6316	86	33	with	with	ADP
fnp-6316	86	34	high	high	ADJ
fnp-6316	86	35	beta	beta	ADJ
fnp-6316	86	36	values	value	NOUN
fnp-6316	86	37	survived	survive	VERB
fnp-6316	86	38	longer	long	ADV
fnp-6316	86	39	.	.	PUNCT
fnp-6316	87	1	these	these	DET
fnp-6316	87	2	findings	finding	NOUN
fnp-6316	87	3	were	be	AUX
fnp-6316	87	4	also	also	ADV
fnp-6316	87	5	corroborated	corroborate	VERB
fnp-6316	87	6	in	in	ADP
fnp-6316	87	7	a	a	DET
fnp-6316	87	8	glioma	glioma	NOUN
fnp-6316	87	9	cell	cell	NOUN
fnp-6316	87	10	line	line	NOUN
fnp-6316	87	11	panel	panel	NOUN
fnp-6316	87	12	exhibiting	exhibit	VERB
fnp-6316	87	13	better	well	ADJ
fnp-6316	87	14	radiosensitivity	radiosensitivity	NOUN
fnp-6316	87	15	in	in	ADP
fnp-6316	87	16	cells	cell	NOUN
fnp-6316	87	17	with	with	ADP
fnp-6316	87	18	a	a	DET
fnp-6316	87	19	higher	high	ADJ
fnp-6316	87	20	beta	beta	NOUN
fnp-6316	87	21	value	value	NOUN
fnp-6316	87	22	.	.	PUNCT
fnp-6316	88	1	in	in	ADP
fnp-6316	88	2	summary	summary	NOUN
fnp-6316	88	3	,	,	PUNCT
fnp-6316	88	4	the	the	DET
fnp-6316	88	5	authors	author	NOUN
fnp-6316	88	6	provide	provide	VERB
fnp-6316	88	7	a	a	DET
fnp-6316	88	8	novel	novel	NOUN
fnp-6316	88	9	,	,	PUNCT
fnp-6316	88	10	highly	highly	ADV
fnp-6316	88	11	important	important	ADJ
fnp-6316	88	12	risk	risk	NOUN
fnp-6316	88	13	stratification	stratification	NOUN
fnp-6316	88	14	for	for	ADP
fnp-6316	88	15	idh	idh	PROPN
fnp-6316	88	16	wildtype	wildtype	NOUN
fnp-6316	88	17	glioblastoma	glioblastoma	NOUN
fnp-6316	88	18	patients	patient	NOUN
fnp-6316	88	19	that	that	PRON
fnp-6316	88	20	might	might	AUX
fnp-6316	88	21	also	also	ADV
fnp-6316	88	22	pave	pave	VERB
fnp-6316	88	23	the	the	DET
fnp-6316	88	24	way	way	NOUN
fnp-6316	88	25	for	for	ADP
fnp-6316	88	26	new	new	ADJ
fnp-6316	88	27	treatment	treatment	NOUN
fnp-6316	88	28	stratifications	stratification	NOUN
fnp-6316	88	29	in	in	ADP
fnp-6316	88	30	the	the	DET
fnp-6316	88	31	future	future	NOUN
fnp-6316	88	32	.	.	PUNCT
fnp-6316	89	1	however	however	ADV
fnp-6316	89	2	,	,	PUNCT
fnp-6316	89	3	a	a	DET
fnp-6316	89	4	comparison	comparison	NOUN
fnp-6316	89	5	with	with	ADP
fnp-6316	89	6	other	other	ADJ
fnp-6316	89	7	tumor	tumor	NOUN
fnp-6316	89	8	entities	entity	NOUN
fnp-6316	89	9	could	could	AUX
fnp-6316	89	10	not	not	PART
fnp-6316	89	11	confirm	confirm	VERB
fnp-6316	89	12	high	high	ADJ
fnp-6316	89	13	methylation	methylation	NOUN
fnp-6316	89	14	levels	level	NOUN
fnp-6316	89	15	as	as	ADP
fnp-6316	89	16	being	be	AUX
fnp-6316	89	17	associated	associate	VERB
fnp-6316	89	18	with	with	ADP
fnp-6316	89	19	tumor	tumor	NOUN
fnp-6316	89	20	aggressiveness	aggressiveness	NOUN
fnp-6316	89	21	in	in	ADP
fnp-6316	89	22	general	general	ADJ
fnp-6316	89	23	.	.	PUNCT
fnp-6316	90	1	3	3	X
fnp-6316	90	2	.	.	X
fnp-6316	90	3	change	change	NOUN
fnp-6316	90	4	in	in	ADP
fnp-6316	90	5	dna	dna	PROPN
fnp-6316	90	6	methylation	methylation	NOUN
fnp-6316	90	7	profile	profile	NOUN
fnp-6316	90	8	in	in	ADP
fnp-6316	90	9	recurrent	recurrent	ADJ
fnp-6316	90	10	glioblastoma	glioblastoma	NOUN
fnp-6316	90	11	[	[	X
fnp-6316	90	12	drexler	drexler	NOUN
fnp-6316	90	13	et	et	PROPN
fnp-6316	90	14	al	al	PROPN
fnp-6316	90	15	.	.	PROPN
fnp-6316	90	16	,	,	PUNCT
fnp-6316	90	17	2024	2024	NUM
fnp-6316	90	18	]	]	PUNCT
fnp-6316	90	19	dna	dna	PROPN
fnp-6316	90	20	methylation	methylation	NOUN
fnp-6316	90	21	profiling	profiling	NOUN
fnp-6316	90	22	has	have	AUX
fnp-6316	90	23	become	become	VERB
fnp-6316	90	24	a	a	DET
fnp-6316	90	25	highly	highly	ADV
fnp-6316	90	26	reliable	reliable	ADJ
fnp-6316	90	27	and	and	CCONJ
fnp-6316	90	28	unbiased	unbiased	ADJ
fnp-6316	90	29	reproducible	reproducible	ADJ
fnp-6316	90	30	diagnostic	diagnostic	ADJ
fnp-6316	90	31	tool	tool	NOUN
fnp-6316	90	32	in	in	ADP
fnp-6316	90	33	neuropathological	neuropathological	ADJ
fnp-6316	90	34	routine	routine	ADJ
fnp-6316	90	35	diagnostics	diagnostic	NOUN
fnp-6316	90	36	[	[	X
fnp-6316	90	37	capper	capper	NOUN
fnp-6316	90	38	et	et	NOUN
fnp-6316	90	39	al	al	PROPN
fnp-6316	90	40	.	.	PROPN
fnp-6316	90	41	,	,	PUNCT
fnp-6316	90	42	2018	2018	NUM
fnp-6316	90	43	]	]	PUNCT
fnp-6316	90	44	.	.	PUNCT
fnp-6316	91	1	however	however	ADV
fnp-6316	91	2	,	,	PUNCT
fnp-6316	91	3	only	only	ADV
fnp-6316	91	4	poor	poor	ADJ
fnp-6316	91	5	data	datum	NOUN
fnp-6316	91	6	exist	exist	VERB
fnp-6316	91	7	about	about	ADP
fnp-6316	91	8	a	a	DET
fnp-6316	91	9	temporal	temporal	ADJ
fnp-6316	91	10	change	change	NOUN
fnp-6316	91	11	of	of	ADP
fnp-6316	91	12	dna	dna	PROPN
fnp-6316	91	13	methylation	methylation	NOUN
fnp-6316	91	14	upon	upon	SCONJ
fnp-6316	91	15	treatment	treatment	NOUN
fnp-6316	91	16	in	in	ADP
fnp-6316	91	17	malignant	malignant	ADJ
fnp-6316	91	18	brain	brain	NOUN
fnp-6316	91	19	tumors	tumor	NOUN
fnp-6316	91	20	that	that	PRON
fnp-6316	91	21	might	might	AUX
fnp-6316	91	22	have	have	VERB
fnp-6316	91	23	an	an	DET
fnp-6316	91	24	impact	impact	NOUN
fnp-6316	91	25	on	on	ADP
fnp-6316	91	26	treatment	treatment	NOUN
fnp-6316	91	27	resistance	resistance	NOUN
fnp-6316	91	28	.	.	PUNCT
fnp-6316	92	1	to	to	PART
fnp-6316	92	2	address	address	VERB
fnp-6316	92	3	this	this	DET
fnp-6316	92	4	question	question	NOUN
fnp-6316	92	5	,	,	PUNCT
fnp-6316	92	6	drexler	drexler	PROPN
fnp-6316	92	7	et	et	PROPN
fnp-6316	92	8	al	al	PROPN
fnp-6316	92	9	.	.	PROPN
fnp-6316	93	1	assessed	assess	VERB
fnp-6316	93	2	paired	pair	VERB
fnp-6316	93	3	primary	primary	ADJ
fnp-6316	93	4	and	and	CCONJ
fnp-6316	93	5	recurrent	recurrent	ADJ
fnp-6316	93	6	glioblastomas	glioblastoma	NOUN
fnp-6316	93	7	of	of	ADP
fnp-6316	93	8	47	47	NUM
fnp-6316	93	9	patients	patient	NOUN
fnp-6316	93	10	by	by	ADP
fnp-6316	93	11	dna	dna	PROPN
fnp-6316	93	12	methylation	methylation	NOUN
fnp-6316	93	13	from	from	ADP
fnp-6316	93	14	tumor	tumor	NOUN
fnp-6316	93	15	bulk	bulk	NOUN
fnp-6316	93	16	and	and	CCONJ
fnp-6316	93	17	plasma	plasma	NOUN
fnp-6316	93	18	,	,	PUNCT
fnp-6316	93	19	mass	mass	NOUN
fnp-6316	93	20	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	93	21	free	free	ADJ
fnp-6316	93	22	neuropathology	neuropathology	NOUN
fnp-6316	93	23	6:10	6:10	NUM
fnp-6316	93	24	(	(	PUNCT
fnp-6316	93	25	2025	2025	NUM
fnp-6316	93	26	)	)	PUNCT
fnp-6316	93	27	michel	michel	PROPN
fnp-6316	93	28	mittelbronn	mittelbronn	PROPN
fnp-6316	93	29	doi	doi	PROPN
fnp-6316	93	30	:	:	PUNCT
fnp-6316	93	31	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	93	32	page	page	NOUN
fnp-6316	93	33	6	6	NUM
fnp-6316	93	34	of	of	ADP
fnp-6316	93	35	19	19	NUM
fnp-6316	93	36	spectrometry	spectrometry	NOUN
fnp-6316	93	37	and	and	CCONJ
fnp-6316	93	38	multiplex	multiplex	PROPN
fnp-6316	93	39	bead	bead	PROPN
fnp-6316	93	40	-	-	PUNCT
fnp-6316	93	41	based	base	VERB
fnp-6316	93	42	immunoassay	immunoassay	NOUN
fnp-6316	94	1	[	[	X
fnp-6316	94	2	drexler	drexler	PROPN
fnp-6316	94	3	et	et	PROPN
fnp-6316	94	4	al	al	PROPN
fnp-6316	94	5	.	.	PROPN
fnp-6316	94	6	,	,	PUNCT
fnp-6316	94	7	2024	2024	NUM
fnp-6316	94	8	]	]	PUNCT
fnp-6316	94	9	.	.	PUNCT
fnp-6316	95	1	a	a	DET
fnp-6316	95	2	potential	potential	ADJ
fnp-6316	95	3	change	change	NOUN
fnp-6316	95	4	even	even	ADV
fnp-6316	95	5	in	in	ADP
fnp-6316	95	6	glioblastoma	glioblastoma	NOUN
fnp-6316	95	7	subclasses	subclass	NOUN
fnp-6316	95	8	might	might	AUX
fnp-6316	95	9	be	be	AUX
fnp-6316	95	10	of	of	ADP
fnp-6316	95	11	importance	importance	NOUN
fnp-6316	95	12	as	as	SCONJ
fnp-6316	95	13	previous	previous	ADJ
fnp-6316	95	14	analyses	analysis	NOUN
fnp-6316	95	15	revealed	reveal	VERB
fnp-6316	95	16	that	that	SCONJ
fnp-6316	95	17	mesenchymal	mesenchymal	NOUN
fnp-6316	95	18	,	,	PUNCT
fnp-6316	95	19	rtk	rtk	PROPN
fnp-6316	95	20	i	i	PROPN
fnp-6316	95	21	and	and	CCONJ
fnp-6316	95	22	rtk	rtk	PROPN
fnp-6316	95	23	ii	ii	PROPN
fnp-6316	95	24	subclasses	subclass	NOUN
fnp-6316	95	25	differed	differ	VERB
fnp-6316	95	26	in	in	ADP
fnp-6316	95	27	patient	patient	ADJ
fnp-6316	95	28	survival	survival	NOUN
fnp-6316	95	29	with	with	ADP
fnp-6316	95	30	15.5	15.5	NUM
fnp-6316	95	31	months	month	NOUN
fnp-6316	95	32	,	,	PUNCT
fnp-6316	95	33	16	16	NUM
fnp-6316	95	34	months	month	NOUN
fnp-6316	95	35	and	and	CCONJ
fnp-6316	95	36	27	27	NUM
fnp-6316	95	37	months	month	NOUN
fnp-6316	95	38	,	,	PUNCT
fnp-6316	95	39	respectively	respectively	ADV
fnp-6316	95	40	[	[	X
fnp-6316	95	41	dejaegher	dejaegher	NOUN
fnp-6316	95	42	et	et	PROPN
fnp-6316	95	43	al	al	PROPN
fnp-6316	95	44	.	.	PROPN
fnp-6316	95	45	,	,	PUNCT
fnp-6316	95	46	2021	2021	NUM
fnp-6316	95	47	]	]	PUNCT
fnp-6316	95	48	.	.	PUNCT
fnp-6316	96	1	in	in	ADP
fnp-6316	96	2	the	the	DET
fnp-6316	96	3	primary	primary	ADJ
fnp-6316	96	4	glioblastoma	glioblastoma	NOUN
fnp-6316	96	5	cohort	cohort	NOUN
fnp-6316	96	6	of	of	ADP
fnp-6316	96	7	drexler	drexler	PROPN
fnp-6316	96	8	et	et	PROPN
fnp-6316	96	9	al	al	PROPN
fnp-6316	96	10	.	.	PROPN
fnp-6316	96	11	,	,	PUNCT
fnp-6316	96	12	dna	dna	PROPN
fnp-6316	96	13	methylation	methylation	NOUN
fnp-6316	96	14	profiling	profiling	NOUN
fnp-6316	96	15	revealed	reveal	VERB
fnp-6316	96	16	the	the	DET
fnp-6316	96	17	following	follow	VERB
fnp-6316	96	18	subclass	subclass	ADJ
fnp-6316	96	19	distribution	distribution	NOUN
fnp-6316	96	20	:	:	PUNCT
fnp-6316	96	21	23.4	23.4	NUM
fnp-6316	96	22	 	 	SPACE
fnp-6316	96	23	%	%	NOUN
fnp-6316	96	24	rtk	rtk	PROPN
fnp-6316	96	25	i	i	PROPN
fnp-6316	96	26	,	,	PUNCT
fnp-6316	96	27	40.4	40.4	NUM
fnp-6316	96	28	 	 	SPACE
fnp-6316	96	29	%	%	NOUN
fnp-6316	96	30	rtk	rtk	PROPN
fnp-6316	96	31	ii	ii	PROPN
fnp-6316	96	32	and	and	CCONJ
fnp-6316	96	33	36.2	36.2	NUM
fnp-6316	96	34	 	 	SPACE
fnp-6316	96	35	%	%	NOUN
fnp-6316	96	36	mesenchymal	mesenchymal	NOUN
fnp-6316	96	37	while	while	SCONJ
fnp-6316	96	38	this	this	DET
fnp-6316	96	39	composition	composition	NOUN
fnp-6316	96	40	changed	change	VERB
fnp-6316	96	41	to	to	ADP
fnp-6316	96	42	12.8	12.8	NUM
fnp-6316	96	43	 	 	SPACE
fnp-6316	96	44	%	%	NOUN
fnp-6316	96	45	rtk	rtk	PROPN
fnp-6316	96	46	i	i	PROPN
fnp-6316	96	47	,	,	PUNCT
fnp-6316	96	48	29.8	29.8	NUM
fnp-6316	96	49	 	 	SPACE
fnp-6316	96	50	%	%	PROPN
fnp-6316	96	51	rtk	rtk	PROPN
fnp-6316	96	52	ii	ii	PROPN
fnp-6316	96	53	,	,	PUNCT
fnp-6316	96	54	40.4	40.4	NUM
fnp-6316	96	55	 	 	SPACE
fnp-6316	96	56	%	%	NOUN
fnp-6316	96	57	mesenchymal	mesenchymal	NOUN
fnp-6316	96	58	and	and	CCONJ
fnp-6316	96	59	17	17	NUM
fnp-6316	96	60	 	 	SPACE
fnp-6316	96	61	%	%	NOUN
fnp-6316	96	62	with	with	ADP
fnp-6316	96	63	no	no	DET
fnp-6316	96	64	match	match	NOUN
fnp-6316	96	65	with	with	ADP
fnp-6316	96	66	a	a	DET
fnp-6316	96	67	known	know	VERB
fnp-6316	96	68	class	class	NOUN
fnp-6316	96	69	(	(	PUNCT
fnp-6316	96	70	figure	figure	NOUN
fnp-6316	96	71	 	 	SPACE
fnp-6316	96	72	3	3	NUM
fnp-6316	96	73	)	)	PUNCT
fnp-6316	96	74	.	.	PUNCT
fnp-6316	97	1	in	in	ADP
fnp-6316	97	2	total	total	ADJ
fnp-6316	97	3	,	,	PUNCT
fnp-6316	97	4	40	40	NUM
fnp-6316	97	5	 	 	SPACE
fnp-6316	97	6	%	%	NOUN
fnp-6316	97	7	of	of	ADP
fnp-6316	97	8	all	all	DET
fnp-6316	97	9	recurrent	recurrent	ADJ
fnp-6316	97	10	gbm	gbm	NOUN
fnp-6316	97	11	did	do	AUX
fnp-6316	97	12	not	not	PART
fnp-6316	97	13	match	match	VERB
fnp-6316	97	14	with	with	ADP
fnp-6316	97	15	the	the	DET
fnp-6316	97	16	subclass	subclass	NOUN
fnp-6316	97	17	obtained	obtain	VERB
fnp-6316	97	18	in	in	ADP
fnp-6316	97	19	the	the	DET
fnp-6316	97	20	primary	primary	ADJ
fnp-6316	97	21	tumors	tumor	NOUN
fnp-6316	97	22	(	(	PUNCT
fnp-6316	97	23	including	include	VERB
fnp-6316	97	24	17	17	NUM
fnp-6316	97	25	 	 	SPACE
fnp-6316	97	26	%	%	NOUN
fnp-6316	97	27	of	of	ADP
fnp-6316	97	28	cases	case	NOUN
fnp-6316	97	29	with	with	ADP
fnp-6316	97	30	no	no	DET
fnp-6316	97	31	match	match	NOUN
fnp-6316	97	32	)	)	PUNCT
fnp-6316	97	33	.	.	PUNCT
fnp-6316	98	1	the	the	DET
fnp-6316	98	2	highest	high	ADJ
fnp-6316	98	3	percentage	percentage	NOUN
fnp-6316	98	4	of	of	ADP
fnp-6316	98	5	transitions	transition	NOUN
fnp-6316	98	6	was	be	AUX
fnp-6316	98	7	towards	towards	ADP
fnp-6316	98	8	the	the	DET
fnp-6316	98	9	mesenchymal	mesenchymal	ADJ
fnp-6316	98	10	subclass	subclass	NOUN
fnp-6316	98	11	(	(	PUNCT
fnp-6316	98	12	72.7	72.7	NUM
fnp-6316	98	13	 	 	SPACE
fnp-6316	98	14	%	%	NOUN
fnp-6316	98	15	)	)	PUNCT
fnp-6316	98	16	.	.	PUNCT
fnp-6316	99	1	thirteen	thirteen	NUM
fnp-6316	99	2	percent	percent	NOUN
fnp-6316	99	3	of	of	ADP
fnp-6316	99	4	all	all	DET
fnp-6316	99	5	patients	patient	NOUN
fnp-6316	99	6	showed	show	VERB
fnp-6316	99	7	a	a	DET
fnp-6316	99	8	switch	switch	NOUN
fnp-6316	99	9	of	of	ADP
fnp-6316	99	10	the	the	DET
fnp-6316	99	11	mgmt	mgmt	PROPN
fnp-6316	99	12	promoter	promoter	NOUN
fnp-6316	99	13	methylation	methylation	NOUN
fnp-6316	99	14	status	status	NOUN
fnp-6316	99	15	,	,	PUNCT
fnp-6316	99	16	mostly	mostly	ADV
fnp-6316	99	17	from	from	ADP
fnp-6316	99	18	a	a	DET
fnp-6316	99	19	methylated	methylate	VERB
fnp-6316	99	20	to	to	ADP
fnp-6316	99	21	a	a	DET
fnp-6316	99	22	nonmethylated	nonmethylate	VERB
fnp-6316	99	23	status	status	NOUN
fnp-6316	99	24	,	,	PUNCT
fnp-6316	99	25	a	a	DET
fnp-6316	99	26	finding	finding	NOUN
fnp-6316	99	27	that	that	PRON
fnp-6316	99	28	is	be	AUX
fnp-6316	99	29	in	in	ADP
fnp-6316	99	30	line	line	NOUN
fnp-6316	99	31	with	with	ADP
fnp-6316	99	32	previous	previous	ADJ
fnp-6316	99	33	analyses	analysis	NOUN
fnp-6316	99	34	performed	perform	VERB
fnp-6316	99	35	in	in	ADP
fnp-6316	99	36	primary	primary	ADJ
fnp-6316	99	37	and	and	CCONJ
fnp-6316	99	38	recurrent	recurrent	ADJ
fnp-6316	99	39	glioblastoma	glioblastoma	NOUN
fnp-6316	100	1	[	[	X
fnp-6316	100	2	choi	choi	NOUN
fnp-6316	100	3	et	et	PROPN
fnp-6316	100	4	al	al	PROPN
fnp-6316	100	5	.	.	PROPN
fnp-6316	100	6	,	,	PUNCT
fnp-6316	100	7	2021	2021	NUM
fnp-6316	100	8	]	]	PUNCT
fnp-6316	100	9	.	.	PUNCT
fnp-6316	101	1	the	the	DET
fnp-6316	101	2	authors	author	NOUN
fnp-6316	101	3	also	also	ADV
fnp-6316	101	4	analyzed	analyze	VERB
fnp-6316	101	5	multiple	multiple	ADJ
fnp-6316	101	6	clinical	clinical	ADJ
fnp-6316	101	7	-pathological	-pathological	ADJ
fnp-6316	101	8	para	para	NOUN
fnp-6316	101	9	meters	meter	NOUN
fnp-6316	101	10	but	but	CCONJ
fnp-6316	101	11	mostly	mostly	ADV
fnp-6316	101	12	found	find	VERB
fnp-6316	101	13	incomplete	incomplete	ADJ
fnp-6316	101	14	resection	resection	NOUN
fnp-6316	101	15	of	of	ADP
fnp-6316	101	16	contrast	contrast	NOUN
fnp-6316	101	17	-	-	PUNCT
fnp-6316	101	18	enhancing	enhance	VERB
fnp-6316	101	19	tumor	tumor	NOUN
fnp-6316	101	20	parts	part	NOUN
fnp-6316	101	21	as	as	ADP
fnp-6316	101	22	a	a	DET
fnp-6316	101	23	significant	significant	ADJ
fnp-6316	101	24	factor	factor	NOUN
fnp-6316	101	25	for	for	ADP
fnp-6316	101	26	subclass	subclass	NOUN
fnp-6316	101	27	transition	transition	NOUN
fnp-6316	101	28	in	in	ADP
fnp-6316	101	29	the	the	DET
fnp-6316	101	30	recurrent	recurrent	ADJ
fnp-6316	101	31	situation	situation	NOUN
fnp-6316	101	32	.	.	PUNCT
fnp-6316	102	1	while	while	SCONJ
fnp-6316	102	2	the	the	DET
fnp-6316	102	3	cellular	cellular	ADJ
fnp-6316	102	4	composition	composition	NOUN
fnp-6316	102	5	did	do	AUX
fnp-6316	102	6	not	not	PART
fnp-6316	102	7	considerably	considerably	ADV
fnp-6316	102	8	vary	vary	VERB
fnp-6316	102	9	between	between	ADP
fnp-6316	102	10	the	the	DET
fnp-6316	102	11	groups	group	NOUN
fnp-6316	102	12	with	with	ADP
fnp-6316	102	13	and	and	CCONJ
fnp-6316	102	14	without	without	ADP
fnp-6316	102	15	subclass	subclass	NOUN
fnp-6316	102	16	change	change	NOUN
fnp-6316	102	17	in	in	ADP
fnp-6316	102	18	general	general	ADJ
fnp-6316	102	19	,	,	PUNCT
fnp-6316	102	20	the	the	DET
fnp-6316	102	21	cohort	cohort	NOUN
fnp-6316	102	22	undergoing	undergo	VERB
fnp-6316	102	23	a	a	DET
fnp-6316	102	24	switch	switch	NOUN
fnp-6316	102	25	towards	towards	ADP
fnp-6316	102	26	a	a	DET
fnp-6316	102	27	mesenchymal	mesenchymal	ADJ
fnp-6316	102	28	phenotype	phenotype	NOUN
fnp-6316	102	29	showed	show	VERB
fnp-6316	102	30	for	for	ADP
fnp-6316	102	31	example	example	NOUN
fnp-6316	102	32	a	a	DET
fnp-6316	102	33	decreased	decrease	VERB
fnp-6316	102	34	number	number	NOUN
fnp-6316	102	35	of	of	ADP
fnp-6316	102	36	immune	immune	ADJ
fnp-6316	102	37	cells	cell	NOUN
fnp-6316	102	38	in	in	ADP
fnp-6316	102	39	the	the	DET
fnp-6316	102	40	primary	primary	ADJ
fnp-6316	102	41	tumor	tumor	NOUN
fnp-6316	102	42	tissue	tissue	NOUN
fnp-6316	102	43	,	,	PUNCT
fnp-6316	102	44	however	however	ADV
fnp-6316	102	45	did	do	AUX
fnp-6316	102	46	not	not	PART
fnp-6316	102	47	reach	reach	VERB
fnp-6316	102	48	the	the	DET
fnp-6316	102	49	level	level	NOUN
fnp-6316	102	50	of	of	ADP
fnp-6316	102	51	significance	significance	NOUN
fnp-6316	102	52	when	when	SCONJ
fnp-6316	102	53	the	the	DET
fnp-6316	102	54	analyses	analysis	NOUN
fnp-6316	102	55	were	be	AUX
fnp-6316	102	56	repeated	repeat	VERB
fnp-6316	102	57	for	for	ADP
fnp-6316	102	58	immune	immune	ADJ
fnp-6316	102	59	cell	cell	NOUN
fnp-6316	102	60	subtypes	subtype	NOUN
fnp-6316	102	61	.	.	PUNCT
fnp-6316	103	1	in	in	ADP
fnp-6316	103	2	contrast	contrast	NOUN
fnp-6316	103	3	,	,	PUNCT
fnp-6316	103	4	higher	high	ADJ
fnp-6316	103	5	methylation	methylation	NOUN
fnp-6316	103	6	signatures	signature	NOUN
fnp-6316	103	7	were	be	AUX
fnp-6316	103	8	observed	observe	VERB
fnp-6316	103	9	for	for	ADP
fnp-6316	103	10	monocytes	monocyte	NOUN
fnp-6316	103	11	,	,	PUNCT
fnp-6316	103	12	b	b	NOUN
fnp-6316	103	13	cells	cell	NOUN
fnp-6316	103	14	and	and	CCONJ
fnp-6316	103	15	neutrophils	neutrophil	NOUN
fnp-6316	103	16	in	in	ADP
fnp-6316	103	17	blood	blood	NOUN
fnp-6316	103	18	of	of	ADP
fnp-6316	103	19	patients	patient	NOUN
fnp-6316	103	20	in	in	ADP
fnp-6316	103	21	the	the	DET
fnp-6316	103	22	primary	primary	ADJ
fnp-6316	103	23	situation	situation	NOUN
fnp-6316	103	24	later	later	ADV
fnp-6316	103	25	showing	show	VERB
fnp-6316	103	26	a	a	DET
fnp-6316	103	27	subclass	subclass	ADJ
fnp-6316	103	28	switch	switch	NOUN
fnp-6316	103	29	towards	towards	ADP
fnp-6316	103	30	a	a	DET
fnp-6316	103	31	mesenchymal	mesenchymal	ADJ
fnp-6316	103	32	phenotype	phenotype	NOUN
fnp-6316	103	33	compared	compare	VERB
fnp-6316	103	34	to	to	ADP
fnp-6316	103	35	the	the	DET
fnp-6316	103	36	cohort	cohort	NOUN
fnp-6316	103	37	with	with	ADP
fnp-6316	103	38	stable	stable	ADJ
fnp-6316	103	39	glioblastoma	glioblastoma	NOUN
fnp-6316	103	40	subclass	subclass	NOUN
fnp-6316	103	41	in	in	ADP
fnp-6316	103	42	the	the	DET
fnp-6316	103	43	figure	figure	NOUN
fnp-6316	103	44	 	 	SPACE
fnp-6316	103	45	3	3	NUM
fnp-6316	103	46	:	:	PUNCT
fnp-6316	103	47	temporal	temporal	ADJ
fnp-6316	103	48	molecular	molecular	ADJ
fnp-6316	103	49	change	change	NOUN
fnp-6316	103	50	between	between	ADP
fnp-6316	103	51	primary	primary	ADJ
fnp-6316	103	52	and	and	CCONJ
fnp-6316	103	53	recurrent	recurrent	ADJ
fnp-6316	103	54	glioblastoma	glioblastoma	NOUN
fnp-6316	103	55	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	103	56	free	free	ADJ
fnp-6316	103	57	neuropathology	neuropathology	NOUN
fnp-6316	103	58	6:10	6:10	NUM
fnp-6316	103	59	(	(	PUNCT
fnp-6316	103	60	2025	2025	NUM
fnp-6316	103	61	)	)	PUNCT
fnp-6316	103	62	michel	michel	PROPN
fnp-6316	103	63	mittelbronn	mittelbronn	PROPN
fnp-6316	103	64	doi	doi	PROPN
fnp-6316	103	65	:	:	PUNCT
fnp-6316	103	66	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	103	67	page	page	NOUN
fnp-6316	103	68	7	7	NUM
fnp-6316	103	69	of	of	ADP
fnp-6316	103	70	19	19	NUM
fnp-6316	103	71	recurrent	recurrent	ADJ
fnp-6316	103	72	situation	situation	NOUN
fnp-6316	103	73	.	.	PUNCT
fnp-6316	104	1	proteomic	proteomic	ADJ
fnp-6316	104	2	analysis	analysis	NOUN
fnp-6316	104	3	revealed	reveal	VERB
fnp-6316	104	4	a	a	DET
fnp-6316	104	5	stronger	strong	ADJ
fnp-6316	104	6	metabolic	metabolic	NOUN
fnp-6316	104	7	and	and	CCONJ
fnp-6316	104	8	catabolic	catabolic	ADJ
fnp-6316	104	9	processes	process	NOUN
fnp-6316	104	10	in	in	ADP
fnp-6316	104	11	the	the	DET
fnp-6316	104	12	primary	primary	ADJ
fnp-6316	104	13	tumor	tumor	NOUN
fnp-6316	104	14	tissue	tissue	NOUN
fnp-6316	104	15	of	of	ADP
fnp-6316	104	16	patients	patient	NOUN
fnp-6316	104	17	later	later	ADV
fnp-6316	104	18	undergoing	undergo	VERB
fnp-6316	104	19	a	a	DET
fnp-6316	104	20	switch	switch	NOUN
fnp-6316	104	21	to	to	ADP
fnp-6316	104	22	mesenchymal	mesenchymal	NOUN
fnp-6316	104	23	subclass	subclass	NOUN
fnp-6316	104	24	.	.	PUNCT
fnp-6316	105	1	of	of	ADP
fnp-6316	105	2	note	note	NOUN
fnp-6316	105	3	,	,	PUNCT
fnp-6316	105	4	no	no	DET
fnp-6316	105	5	association	association	NOUN
fnp-6316	105	6	of	of	ADP
fnp-6316	105	7	subclass	subclass	NOUN
fnp-6316	105	8	changes	change	NOUN
fnp-6316	105	9	with	with	ADP
fnp-6316	105	10	patient	patient	ADJ
fnp-6316	105	11	survival	survival	NOUN
fnp-6316	105	12	was	be	AUX
fnp-6316	105	13	observed	observe	VERB
fnp-6316	105	14	.	.	PUNCT
fnp-6316	106	1	this	this	DET
fnp-6316	106	2	study	study	NOUN
fnp-6316	106	3	is	be	AUX
fnp-6316	106	4	of	of	ADP
fnp-6316	106	5	high	high	ADJ
fnp-6316	106	6	importance	importance	NOUN
fnp-6316	106	7	for	for	ADP
fnp-6316	106	8	the	the	DET
fnp-6316	106	9	understanding	understanding	NOUN
fnp-6316	106	10	of	of	ADP
fnp-6316	106	11	temporal	temporal	ADJ
fnp-6316	106	12	molecular	molecular	ADJ
fnp-6316	106	13	changes	change	NOUN
fnp-6316	106	14	in	in	ADP
fnp-6316	106	15	glioblastoma	glioblastoma	NOUN
fnp-6316	106	16	and	and	CCONJ
fnp-6316	106	17	underscores	underscore	VERB
fnp-6316	106	18	the	the	DET
fnp-6316	106	19	necessity	necessity	NOUN
fnp-6316	106	20	to	to	PART
fnp-6316	106	21	re	re	VERB
fnp-6316	106	22	-	-	VERB
fnp-6316	106	23	perform	perform	VERB
fnp-6316	106	24	full	full	ADJ
fnp-6316	106	25	molecular	molecular	ADJ
fnp-6316	106	26	assessment	assessment	NOUN
fnp-6316	106	27	in	in	ADP
fnp-6316	106	28	the	the	DET
fnp-6316	106	29	recurrent	recurrent	ADJ
fnp-6316	106	30	situation	situation	NOUN
fnp-6316	106	31	,	,	PUNCT
fnp-6316	106	32	especially	especially	ADV
fnp-6316	106	33	as	as	SCONJ
fnp-6316	106	34	also	also	ADV
fnp-6316	106	35	broadly	broadly	ADV
fnp-6316	106	36	accepted	accept	VERB
fnp-6316	106	37	molecular	molecular	ADJ
fnp-6316	106	38	biomarkers	biomarker	NOUN
fnp-6316	106	39	such	such	ADJ
fnp-6316	106	40	as	as	ADP
fnp-6316	106	41	mgmt	mgmt	PROPN
fnp-6316	106	42	promoter	promoter	NOUN
fnp-6316	106	43	methylation	methylation	NOUN
fnp-6316	106	44	status	status	NOUN
fnp-6316	106	45	may	may	AUX
fnp-6316	106	46	change	change	VERB
fnp-6316	106	47	over	over	ADP
fnp-6316	106	48	time	time	NOUN
fnp-6316	106	49	.	.	PUNCT
fnp-6316	107	1	to	to	PART
fnp-6316	107	2	which	which	DET
fnp-6316	107	3	degree	degree	NOUN
fnp-6316	107	4	radiochemotherapy	radiochemotherapy	NOUN
fnp-6316	107	5	induces	induce	VERB
fnp-6316	107	6	the	the	DET
fnp-6316	107	7	temporal	temporal	ADJ
fnp-6316	107	8	switch	switch	NOUN
fnp-6316	107	9	towards	towards	ADP
fnp-6316	107	10	a	a	DET
fnp-6316	107	11	mesenchymal	mesenchymal	NOUN
fnp-6316	107	12	subclass	subclass	NOUN
fnp-6316	107	13	phenotype	phenotype	NOUN
fnp-6316	107	14	has	have	VERB
fnp-6316	107	15	to	to	PART
fnp-6316	107	16	be	be	AUX
fnp-6316	107	17	further	far	ADV
fnp-6316	107	18	elucidated	elucidate	VERB
fnp-6316	107	19	.	.	PUNCT
fnp-6316	108	1	4	4	X
fnp-6316	108	2	.	.	X
fnp-6316	108	3	glioblastoma	glioblastoma	NOUN
fnp-6316	108	4	evolution	evolution	NOUN
fnp-6316	108	5	and	and	CCONJ
fnp-6316	108	6	heterogeneity	heterogeneity	NOUN
fnp-6316	108	7	from	from	ADP
fnp-6316	108	8	a	a	DET
fnp-6316	108	9	whole	whole	ADJ
fnp-6316	108	10	tumor	tumor	NOUN
fnp-6316	108	11	perspective	perspective	NOUN
fnp-6316	109	1	[	[	X
fnp-6316	109	2	mathur	mathur	PROPN
fnp-6316	109	3	et	et	PROPN
fnp-6316	109	4	al	al	PROPN
fnp-6316	109	5	.	.	PROPN
fnp-6316	109	6	,	,	PUNCT
fnp-6316	109	7	2024	2024	NUM
fnp-6316	109	8	]	]	PUNCT
fnp-6316	109	9	glioblastoma	glioblastoma	NOUN
fnp-6316	109	10	is	be	AUX
fnp-6316	109	11	a	a	DET
fnp-6316	109	12	highly	highly	ADV
fnp-6316	109	13	heterogenous	heterogenous	ADJ
fnp-6316	109	14	neoplasm	neoplasm	NOUN
fnp-6316	109	15	composed	compose	VERB
fnp-6316	109	16	of	of	ADP
fnp-6316	109	17	both	both	DET
fnp-6316	109	18	tumor	tumor	NOUN
fnp-6316	109	19	and	and	CCONJ
fnp-6316	109	20	non	non	ADJ
fnp-6316	109	21	-	-	ADJ
fnp-6316	109	22	neoplastic	neoplastic	ADJ
fnp-6316	109	23	cells	cell	NOUN
fnp-6316	109	24	of	of	ADP
fnp-6316	109	25	the	the	DET
fnp-6316	109	26	microenvironment	microenvironment	NOUN
fnp-6316	109	27	.	.	PUNCT
fnp-6316	110	1	in	in	ADP
fnp-6316	110	2	addition	addition	NOUN
fnp-6316	110	3	,	,	PUNCT
fnp-6316	110	4	little	little	ADJ
fnp-6316	110	5	is	be	AUX
fnp-6316	110	6	known	know	VERB
fnp-6316	110	7	about	about	ADP
fnp-6316	110	8	the	the	DET
fnp-6316	110	9	overall	overall	ADJ
fnp-6316	110	10	molecular	molecular	ADJ
fnp-6316	110	11	heterogeneity	heterogeneity	NOUN
fnp-6316	110	12	including	include	VERB
fnp-6316	110	13	genetic	genetic	ADJ
fnp-6316	110	14	,	,	PUNCT
fnp-6316	110	15	epigenetic	epigenetic	ADJ
fnp-6316	110	16	and	and	CCONJ
fnp-6316	110	17	 	 	SPACE
fnp-6316	110	18	/	/	SYM
fnp-6316	110	19	 	 	SPACE
fnp-6316	110	20	or	or	CCONJ
fnp-6316	110	21	metabolic	metabolic	NOUN
fnp-6316	110	22	features	feature	NOUN
fnp-6316	110	23	as	as	ADP
fnp-6316	110	24	diagnostics	diagnostic	NOUN
fnp-6316	110	25	is	be	AUX
fnp-6316	110	26	mostly	mostly	ADV
fnp-6316	110	27	performed	perform	VERB
fnp-6316	110	28	on	on	ADP
fnp-6316	110	29	smaller	small	ADJ
fnp-6316	110	30	bulk	bulk	ADJ
fnp-6316	110	31	tissue	tissue	NOUN
fnp-6316	110	32	parts	part	NOUN
fnp-6316	110	33	.	.	PUNCT
fnp-6316	111	1	in	in	ADP
fnp-6316	111	2	a	a	DET
fnp-6316	111	3	previous	previous	ADJ
fnp-6316	111	4	large	large	ADJ
fnp-6316	111	5	-	-	PUNCT
fnp-6316	111	6	scale	scale	NOUN
fnp-6316	111	7	approach	approach	NOUN
fnp-6316	111	8	,	,	PUNCT
fnp-6316	111	9	a	a	DET
fnp-6316	111	10	glioblastoma	glioblastoma	NOUN
fnp-6316	111	11	atlas	atlas	PROPN
fnp-6316	111	12	linking	link	VERB
fnp-6316	111	13	classical	classical	ADJ
fnp-6316	111	14	histomorphological	histomorphological	ADJ
fnp-6316	111	15	features	feature	NOUN
fnp-6316	111	16	with	with	ADP
fnp-6316	111	17	transcriptional	transcriptional	ADJ
fnp-6316	111	18	profiles	profile	NOUN
fnp-6316	111	19	,	,	PUNCT
fnp-6316	111	20	the	the	DET
fnp-6316	111	21	latter	latter	ADJ
fnp-6316	111	22	assessed	assess	VERB
fnp-6316	111	23	by	by	ADP
fnp-6316	111	24	in	in	ADP
fnp-6316	111	25	-	-	PUNCT
fnp-6316	111	26	situ	situ	NOUN
fnp-6316	111	27	hybridization	hybridization	NOUN
fnp-6316	111	28	,	,	PUNCT
fnp-6316	111	29	revealed	reveal	VERB
fnp-6316	111	30	a	a	DET
fnp-6316	111	31	strong	strong	ADJ
fnp-6316	111	32	regional	regional	ADJ
fnp-6316	111	33	molecular	molecular	ADJ
fnp-6316	111	34	heterogeneity	heterogeneity	NOUN
fnp-6316	111	35	partly	partly	ADV
fnp-6316	111	36	related	relate	VERB
fnp-6316	111	37	to	to	ADP
fnp-6316	111	38	microscopic	microscopic	ADJ
fnp-6316	111	39	characteristics	characteristic	NOUN
fnp-6316	112	1	[	[	X
fnp-6316	112	2	puchalski	puchalski	NOUN
fnp-6316	112	3	et	et	NOUN
fnp-6316	112	4	al	al	PROPN
fnp-6316	112	5	.	.	PROPN
fnp-6316	112	6	,	,	PUNCT
fnp-6316	112	7	2018	2018	NUM
fnp-6316	112	8	]	]	PUNCT
fnp-6316	112	9	.	.	PUNCT
fnp-6316	113	1	however	however	ADV
fnp-6316	113	2	,	,	PUNCT
fnp-6316	113	3	as	as	SCONJ
fnp-6316	113	4	these	these	DET
fnp-6316	113	5	previous	previous	ADJ
fnp-6316	113	6	findings	finding	NOUN
fnp-6316	113	7	were	be	AUX
fnp-6316	113	8	also	also	ADV
fnp-6316	113	9	derived	derive	VERB
fnp-6316	113	10	from	from	ADP
fnp-6316	113	11	preselected	preselecte	VERB
fnp-6316	113	12	tissue	tissue	NOUN
fnp-6316	113	13	blocks	block	NOUN
fnp-6316	113	14	not	not	PART
fnp-6316	113	15	representing	represent	VERB
fnp-6316	113	16	the	the	DET
fnp-6316	113	17	entire	entire	ADJ
fnp-6316	113	18	regional	regional	ADJ
fnp-6316	113	19	spectrum	spectrum	NOUN
fnp-6316	113	20	of	of	ADP
fnp-6316	113	21	glioblastoma	glioblastoma	NOUN
fnp-6316	113	22	,	,	PUNCT
fnp-6316	113	23	mathur	mathur	PROPN
fnp-6316	113	24	et	et	PROPN
fnp-6316	113	25	al	al	PROPN
fnp-6316	113	26	.	.	PROPN
fnp-6316	113	27	sampled	sample	VERB
fnp-6316	113	28	multiple	multiple	ADJ
fnp-6316	113	29	tissues	tissue	NOUN
fnp-6316	113	30	(	(	PUNCT
fnp-6316	113	31	n	n	CCONJ
fnp-6316	113	32	 	 	SPACE
fnp-6316	113	33	=	=	NOUN
fnp-6316	113	34	 	 	SPACE
fnp-6316	113	35	103	103	NUM
fnp-6316	113	36	)	)	PUNCT
fnp-6316	113	37	from	from	ADP
fnp-6316	113	38	the	the	DET
fnp-6316	113	39	10	10	NUM
fnp-6316	113	40	patients	patient	NOUN
fnp-6316	113	41	using	use	VERB
fnp-6316	113	42	3d	3d	NUM
fnp-6316	113	43	surgical	surgical	ADJ
fnp-6316	113	44	neuronavigation	neuronavigation	NOUN
fnp-6316	113	45	to	to	PART
fnp-6316	113	46	obtain	obtain	VERB
fnp-6316	113	47	representative	representative	ADJ
fnp-6316	113	48	areas	area	NOUN
fnp-6316	113	49	of	of	ADP
fnp-6316	113	50	the	the	DET
fnp-6316	113	51	tumor	tumor	NOUN
fnp-6316	113	52	core	core	NOUN
fnp-6316	113	53	,	,	PUNCT
fnp-6316	113	54	periphery	periphery	NOUN
fnp-6316	113	55	and	and	CCONJ
fnp-6316	113	56	contrast	contrast	NOUN
fnp-6316	113	57	-	-	PUNCT
fnp-6316	113	58	enhancing	enhance	VERB
fnp-6316	113	59	regions	region	NOUN
fnp-6316	113	60	[	[	X
fnp-6316	113	61	mathur	mathur	PROPN
fnp-6316	113	62	et	et	PROPN
fnp-6316	113	63	al	al	PROPN
fnp-6316	113	64	.	.	PROPN
fnp-6316	113	65	,	,	PUNCT
fnp-6316	113	66	2024	2024	NUM
fnp-6316	113	67	]	]	PUNCT
fnp-6316	113	68	.	.	PUNCT
fnp-6316	114	1	furthermore	furthermore	ADV
fnp-6316	114	2	,	,	PUNCT
fnp-6316	114	3	the	the	DET
fnp-6316	114	4	biopsy	biopsy	NOUN
fnp-6316	114	5	positions	position	NOUN
fnp-6316	114	6	were	be	AUX
fnp-6316	114	7	correlated	correlate	VERB
fnp-6316	114	8	with	with	ADP
fnp-6316	114	9	preoperative	preoperative	ADJ
fnp-6316	114	10	mri	mri	NOUN
fnp-6316	114	11	scans	scan	NOUN
fnp-6316	114	12	to	to	PART
fnp-6316	114	13	generate	generate	VERB
fnp-6316	114	14	a	a	DET
fnp-6316	114	15	representative	representative	ADJ
fnp-6316	114	16	3d	3d	NUM
fnp-6316	114	17	model	model	NOUN
fnp-6316	114	18	of	of	ADP
fnp-6316	114	19	the	the	DET
fnp-6316	114	20	entire	entire	ADJ
fnp-6316	114	21	glioblastoma	glioblastoma	NOUN
fnp-6316	114	22	.	.	PUNCT
fnp-6316	115	1	the	the	DET
fnp-6316	115	2	small	small	ADJ
fnp-6316	115	3	biopsy	biopsy	NOUN
fnp-6316	115	4	samples	sample	NOUN
fnp-6316	115	5	were	be	AUX
fnp-6316	115	6	assessed	assess	VERB
fnp-6316	115	7	by	by	ADP
fnp-6316	115	8	histopathological	histopathological	ADJ
fnp-6316	115	9	analyses	analysis	NOUN
fnp-6316	115	10	,	,	PUNCT
fnp-6316	115	11	highthroughput	highthroughput	VERB
fnp-6316	115	12	chromosome	chromosome	NOUN
fnp-6316	115	13	conformation	conformation	NOUN
fnp-6316	115	14	capture	capture	NOUN
fnp-6316	115	15	(	(	PUNCT
fnp-6316	115	16	hi	hi	INTJ
fnp-6316	115	17	-	-	NOUN
fnp-6316	115	18	c	c	NOUN
fnp-6316	115	19	)	)	PUNCT
fnp-6316	115	20	,	,	PUNCT
fnp-6316	115	21	whole	whole	ADJ
fnp-6316	115	22	exome	exome	NOUN
fnp-6316	115	23	sequencing	sequence	VERB
fnp-6316	115	24	(	(	PUNCT
fnp-6316	115	25	wes	wes	PROPN
fnp-6316	115	26	)	)	PUNCT
fnp-6316	115	27	,	,	PUNCT
fnp-6316	115	28	rna	rna	NOUN
fnp-6316	115	29	sequ	sequ	VERB
fnp-6316	115	30	encing	ence	VERB
fnp-6316	115	31	(	(	PUNCT
fnp-6316	115	32	rna	rna	NOUN
fnp-6316	115	33	-	-	PUNCT
fnp-6316	115	34	seq	seq	NOUN
fnp-6316	115	35	)	)	PUNCT
fnp-6316	115	36	as	as	ADV
fnp-6316	115	37	well	well	ADV
fnp-6316	115	38	as	as	ADP
fnp-6316	115	39	assay	assay	VERB
fnp-6316	115	40	for	for	ADP
fnp-6316	115	41	transposaseaccessible	transposaseaccessible	ADJ
fnp-6316	115	42	chromatin	chromatin	NOUN
fnp-6316	115	43	with	with	ADP
fnp-6316	115	44	high	high	ADJ
fnp-6316	115	45	-	-	PUNCT
fnp-6316	115	46	throughput	throughput	NOUN
fnp-6316	115	47	sequencing	sequence	VERB
fnp-6316	115	48	(	(	PUNCT
fnp-6316	115	49	atac	atac	NOUN
fnp-6316	115	50	-	-	PUNCT
fnp-6316	115	51	seq	seq	NOUN
fnp-6316	115	52	,	,	PUNCT
fnp-6316	115	53	for	for	ADP
fnp-6316	115	54	tissue	tissue	NOUN
fnp-6316	115	55	and	and	CCONJ
fnp-6316	115	56	single	single	ADJ
fnp-6316	115	57	nucleus	nucleus	NOUN
fnp-6316	115	58	)	)	PUNCT
fnp-6316	115	59	(	(	PUNCT
fnp-6316	115	60	for	for	ADP
fnp-6316	115	61	summary	summary	NOUN
fnp-6316	115	62	,	,	PUNCT
fnp-6316	115	63	see	see	VERB
fnp-6316	115	64	figure	figure	NOUN
fnp-6316	115	65	 	 	SPACE
fnp-6316	115	66	4	4	NUM
fnp-6316	115	67	)	)	PUNCT
fnp-6316	115	68	.	.	PUNCT
fnp-6316	116	1	the	the	DET
fnp-6316	116	2	authors	author	NOUN
fnp-6316	116	3	detected	detect	VERB
fnp-6316	116	4	a	a	DET
fnp-6316	116	5	vast	vast	ADJ
fnp-6316	116	6	genetic	genetic	ADJ
fnp-6316	116	7	and	and	CCONJ
fnp-6316	116	8	transcriptional	transcriptional	ADJ
fnp-6316	116	9	heterogeneity	heterogeneity	NOUN
fnp-6316	116	10	within	within	ADP
fnp-6316	116	11	the	the	DET
fnp-6316	116	12	patients	patient	NOUN
fnp-6316	116	13	.	.	PUNCT
fnp-6316	117	1	only	only	ADV
fnp-6316	117	2	one	one	NUM
fnp-6316	117	3	out	out	ADP
fnp-6316	117	4	of	of	ADP
fnp-6316	117	5	the	the	DET
fnp-6316	117	6	ten	ten	NUM
fnp-6316	117	7	patients	patient	NOUN
fnp-6316	117	8	showed	show	VERB
fnp-6316	117	9	a	a	DET
fnp-6316	117	10	consistent	consistent	ADJ
fnp-6316	117	11	signature	signature	NOUN
fnp-6316	117	12	in	in	ADP
fnp-6316	117	13	all	all	DET
fnp-6316	117	14	biopsies	biopsy	NOUN
fnp-6316	117	15	regarding	regard	VERB
fnp-6316	117	16	the	the	DET
fnp-6316	117	17	previously	previously	ADV
fnp-6316	117	18	published	publish	VERB
fnp-6316	117	19	,	,	PUNCT
fnp-6316	117	20	gene	gene	NOUN
fnp-6316	117	21	expression	expression	NOUN
fnp-6316	117	22	-	-	PUNCT
fnp-6316	117	23	based	base	VERB
fnp-6316	117	24	molecular	molecular	ADJ
fnp-6316	117	25	classification	classification	NOUN
fnp-6316	117	26	into	into	ADP
fnp-6316	117	27	proneural	proneural	ADJ
fnp-6316	117	28	,	,	PUNCT
fnp-6316	117	29	neural	neural	ADJ
fnp-6316	117	30	,	,	PUNCT
fnp-6316	117	31	classic	classic	ADJ
fnp-6316	117	32	or	or	CCONJ
fnp-6316	117	33	mesenchymal	mesenchymal	ADJ
fnp-6316	117	34	subtypes	subtype	NOUN
fnp-6316	117	35	while	while	SCONJ
fnp-6316	117	36	all	all	DET
fnp-6316	117	37	other	other	ADJ
fnp-6316	117	38	patients	patient	NOUN
fnp-6316	117	39	displayed	display	VERB
fnp-6316	117	40	mixed	mixed	ADJ
fnp-6316	117	41	intraindividual	intraindividual	ADJ
fnp-6316	117	42	signatures	signature	NOUN
fnp-6316	118	1	[	[	X
fnp-6316	118	2	verhaak	verhaak	NOUN
fnp-6316	118	3	et	et	PROPN
fnp-6316	118	4	al	al	PROPN
fnp-6316	118	5	.	.	PROPN
fnp-6316	118	6	,	,	PUNCT
fnp-6316	118	7	2010	2010	NUM
fnp-6316	118	8	]	]	PUNCT
fnp-6316	118	9	.	.	PUNCT
fnp-6316	119	1	of	of	ADP
fnp-6316	119	2	note	note	NOUN
fnp-6316	119	3	,	,	PUNCT
fnp-6316	119	4	tumor	tumor	NOUN
fnp-6316	119	5	biopsies	biopsy	NOUN
fnp-6316	119	6	from	from	ADP
fnp-6316	119	7	the	the	DET
fnp-6316	119	8	tumor	tumor	NOUN
fnp-6316	119	9	cores	core	NOUN
fnp-6316	119	10	more	more	ADV
fnp-6316	119	11	frequently	frequently	ADV
fnp-6316	119	12	showed	show	VERB
fnp-6316	119	13	a	a	DET
fnp-6316	119	14	mesenchymal	mesenchymal	NOUN
fnp-6316	119	15	or	or	CCONJ
fnp-6316	119	16	classic	classic	ADJ
fnp-6316	119	17	signature	signature	NOUN
fnp-6316	119	18	while	while	SCONJ
fnp-6316	119	19	more	more	ADJ
fnp-6316	119	20	peripheral	peripheral	ADJ
fnp-6316	119	21	biopsies	biopsy	NOUN
fnp-6316	119	22	revealed	reveal	VERB
fnp-6316	119	23	rather	rather	ADV
fnp-6316	119	24	neural	neural	ADJ
fnp-6316	119	25	or	or	CCONJ
fnp-6316	119	26	proneural	proneural	ADJ
fnp-6316	119	27	signatures	signature	NOUN
fnp-6316	119	28	.	.	PUNCT
fnp-6316	120	1	the	the	DET
fnp-6316	120	2	authors	author	NOUN
fnp-6316	120	3	also	also	ADV
fnp-6316	120	4	discovered	discover	VERB
fnp-6316	120	5	distinct	distinct	ADJ
fnp-6316	120	6	neurodevelopmental	neurodevelopmental	ADJ
fnp-6316	120	7	transcriptomic	transcriptomic	ADJ
fnp-6316	120	8	signatures	signature	NOUN
fnp-6316	120	9	such	such	ADJ
fnp-6316	120	10	as	as	ADP
fnp-6316	120	11	for	for	ADP
fnp-6316	120	12	example	example	NOUN
fnp-6316	120	13	glioblastoma	glioblastoma	NOUN
fnp-6316	120	14	with	with	ADP
fnp-6316	120	15	a	a	DET
fnp-6316	120	16	gain	gain	NOUN
fnp-6316	120	17	of	of	ADP
fnp-6316	120	18	chromosome	chromosome	NOUN
fnp-6316	120	19	7	7	NUM
fnp-6316	120	20	(	(	PUNCT
fnp-6316	120	21	with	with	ADP
fnp-6316	120	22	the	the	DET
fnp-6316	120	23	egfr	egfr	NOUN
fnp-6316	120	24	,	,	PUNCT
fnp-6316	120	25	ptprz1	ptprz1	PROPN
fnp-6316	120	26	and	and	CCONJ
fnp-6316	120	27	ptn	ptn	PROPN
fnp-6316	120	28	genes	gene	NOUN
fnp-6316	120	29	)	)	PUNCT
fnp-6316	120	30	being	be	AUX
fnp-6316	120	31	associated	associate	VERB
fnp-6316	120	32	with	with	ADP
fnp-6316	120	33	glioblastoma	glioblastoma	NOUN
fnp-6316	120	34	cells	cell	NOUN
fnp-6316	120	35	in	in	ADP
fnp-6316	120	36	an	an	DET
fnp-6316	120	37	intermediate	intermediate	ADJ
fnp-6316	120	38	progenitor	progenitor	NOUN
fnp-6316	120	39	cell	cell	NOUN
fnp-6316	120	40	(	(	PUNCT
fnp-6316	120	41	ipc	ipc	PROPN
fnp-6316	120	42	)	)	PUNCT
fnp-6316	120	43	transit	transit	NOUN
fnp-6316	120	44	-	-	PUNCT
fnp-6316	120	45	amplifying	amplify	VERB
fnp-6316	120	46	state	state	NOUN
fnp-6316	120	47	or	or	CCONJ
fnp-6316	120	48	–	–	PUNCT
fnp-6316	120	49	in	in	ADP
fnp-6316	120	50	contrast	contrast	NOUN
fnp-6316	120	51	glioblastoma	glioblastoma	NOUN
fnp-6316	120	52	with	with	ADP
fnp-6316	120	53	a	a	DET
fnp-6316	120	54	primitive	primitive	ADJ
fnp-6316	120	55	neuronal	neuronal	ADJ
fnp-6316	120	56	component	component	NOUN
fnp-6316	120	57	,	,	PUNCT
fnp-6316	120	58	however	however	ADV
fnp-6316	120	59	without	without	ADP
fnp-6316	120	60	a	a	DET
fnp-6316	120	61	gain	gain	NOUN
fnp-6316	120	62	of	of	ADP
fnp-6316	120	63	chromosome	chromosome	NOUN
fnp-6316	120	64	7	7	NUM
fnp-6316	120	65	,	,	PUNCT
fnp-6316	120	66	showing	show	VERB
fnp-6316	120	67	transcriptional	transcriptional	ADJ
fnp-6316	120	68	signatures	signature	NOUN
fnp-6316	120	69	typically	typically	ADV
fnp-6316	120	70	observed	observe	VERB
fnp-6316	120	71	in	in	ADP
fnp-6316	120	72	cells	cell	NOUN
fnp-6316	120	73	differentiating	differentiate	VERB
fnp-6316	120	74	from	from	ADP
fnp-6316	120	75	ipcs	ipc	NOUN
fnp-6316	120	76	to	to	ADP
fnp-6316	120	77	neurons	neuron	NOUN
fnp-6316	120	78	.	.	PUNCT
fnp-6316	121	1	additional	additional	ADJ
fnp-6316	121	2	signatures	signature	NOUN
fnp-6316	121	3	in	in	ADP
fnp-6316	121	4	the	the	DET
fnp-6316	121	5	tumor	tumor	NOUN
fnp-6316	121	6	center	center	NOUN
fnp-6316	121	7	comprised	comprise	VERB
fnp-6316	121	8	an	an	DET
fnp-6316	121	9	immune	immune	ADJ
fnp-6316	121	10	-	-	PUNCT
fnp-6316	121	11	hot	hot	ADJ
fnp-6316	121	12	microenvironment	microenvironment	NOUN
fnp-6316	121	13	with	with	ADP
fnp-6316	121	14	interferon	interferon	ADJ
fnp-6316	121	15	signaling	signaling	NOUN
fnp-6316	121	16	and	and	CCONJ
fnp-6316	121	17	t	t	NOUN
fnp-6316	121	18	cell	cell	NOUN
fnp-6316	121	19	infiltration	infiltration	NOUN
fnp-6316	121	20	versus	versus	ADP
fnp-6316	121	21	immune	immune	NOUN
fnp-6316	121	22	-	-	PUNCT
fnp-6316	121	23	cold	cold	ADJ
fnp-6316	121	24	areas	area	NOUN
fnp-6316	121	25	with	with	ADP
fnp-6316	121	26	a	a	DET
fnp-6316	121	27	mesenchymal	mesenchymal	ADJ
fnp-6316	121	28	transcriptomic	transcriptomic	ADJ
fnp-6316	121	29	signature	signature	NOUN
fnp-6316	121	30	.	.	PUNCT
fnp-6316	122	1	while	while	SCONJ
fnp-6316	122	2	most	most	ADJ
fnp-6316	122	3	mutations	mutation	NOUN
fnp-6316	122	4	were	be	AUX
fnp-6316	122	5	highly	highly	ADV
fnp-6316	122	6	heterogenous	heterogenous	ADJ
fnp-6316	122	7	,	,	PUNCT
fnp-6316	122	8	chromothripsis	chromothripsi	NOUN
fnp-6316	122	9	seems	seem	VERB
fnp-6316	122	10	to	to	PART
fnp-6316	122	11	be	be	AUX
fnp-6316	122	12	a	a	DET
fnp-6316	122	13	very	very	ADV
fnp-6316	122	14	early	early	ADJ
fnp-6316	122	15	event	event	NOUN
fnp-6316	122	16	in	in	ADP
fnp-6316	122	17	gliomagenesis	gliomagenesis	NOUN
fnp-6316	122	18	with	with	ADP
fnp-6316	122	19	virtually	virtually	ADV
fnp-6316	122	20	no	no	DET
fnp-6316	122	21	intraindividual	intraindividual	ADJ
fnp-6316	122	22	heterogeneity	heterogeneity	NOUN
fnp-6316	122	23	.	.	PUNCT
fnp-6316	123	1	most	most	ADV
fnp-6316	123	2	importantly	importantly	ADV
fnp-6316	123	3	,	,	PUNCT
fnp-6316	123	4	the	the	DET
fnp-6316	123	5	authors	author	NOUN
fnp-6316	123	6	presented	present	VERB
fnp-6316	123	7	several	several	ADJ
fnp-6316	123	8	novel	novel	ADJ
fnp-6316	123	9	potential	potential	ADJ
fnp-6316	123	10	diagnostic	diagnostic	ADJ
fnp-6316	123	11	biomarkers	biomarker	NOUN
fnp-6316	123	12	and	and	CCONJ
fnp-6316	123	13	treatment	treatment	NOUN
fnp-6316	123	14	targets	target	NOUN
fnp-6316	123	15	,	,	PUNCT
fnp-6316	123	16	such	such	ADJ
fnp-6316	123	17	as	as	ADP
fnp-6316	123	18	the	the	DET
fnp-6316	123	19	activator	activator	NOUN
fnp-6316	123	20	protein	protein	NOUN
fnp-6316	123	21	1	1	NUM
fnp-6316	123	22	(	(	PUNCT
fnp-6316	123	23	ap-1	ap-1	NOUN
fnp-6316	123	24	)	)	PUNCT
fnp-6316	123	25	pathway	pathway	NOUN
fnp-6316	123	26	or	or	CCONJ
fnp-6316	123	27	several	several	ADJ
fnp-6316	123	28	gene	gene	NOUN
fnp-6316	123	29	fusions	fusion	NOUN
fnp-6316	123	30	that	that	PRON
fnp-6316	123	31	were	be	AUX
fnp-6316	123	32	missed	miss	VERB
fnp-6316	123	33	by	by	ADP
fnp-6316	123	34	clinical	clinical	ADJ
fnp-6316	123	35	ngs	ng	NOUN
fnp-6316	123	36	analyses	analysis	NOUN
fnp-6316	123	37	as	as	ADP
fnp-6316	123	38	breakpoints	breakpoint	NOUN
fnp-6316	123	39	were	be	AUX
fnp-6316	123	40	outside	outside	ADJ
fnp-6316	123	41	exons	exon	NOUN
fnp-6316	123	42	.	.	PUNCT
fnp-6316	124	1	with	with	ADP
fnp-6316	124	2	this	this	DET
fnp-6316	124	3	work	work	NOUN
fnp-6316	124	4	,	,	PUNCT
fnp-6316	124	5	mathur	mathur	PROPN
fnp-6316	124	6	et	et	PROPN
fnp-6316	124	7	al	al	PROPN
fnp-6316	124	8	.	.	PROPN
fnp-6316	124	9	considerably	considerably	ADV
fnp-6316	124	10	contributed	contribute	VERB
fnp-6316	124	11	to	to	ADP
fnp-6316	124	12	the	the	DET
fnp-6316	124	13	understanding	understanding	NOUN
fnp-6316	124	14	of	of	ADP
fnp-6316	124	15	glioblastoma	glioblastoma	NOUN
fnp-6316	124	16	evolution	evolution	NOUN
fnp-6316	124	17	and	and	CCONJ
fnp-6316	124	18	heterogeneity	heterogeneity	NOUN
fnp-6316	124	19	and	and	CCONJ
fnp-6316	124	20	provide	provide	VERB
fnp-6316	124	21	promising	promise	VERB
fnp-6316	124	22	therapeutic	therapeutic	ADJ
fnp-6316	124	23	targets	target	NOUN
fnp-6316	124	24	for	for	ADP
fnp-6316	124	25	further	further	ADJ
fnp-6316	124	26	assessment	assessment	NOUN
fnp-6316	124	27	.	.	PUNCT
fnp-6316	125	1	for	for	ADP
fnp-6316	125	2	more	more	ADJ
fnp-6316	125	3	in	in	ADP
fnp-6316	125	4	-	-	PUNCT
fnp-6316	125	5	depth	depth	NOUN
fnp-6316	125	6	exploration	exploration	NOUN
fnp-6316	125	7	of	of	ADP
fnp-6316	125	8	the	the	DET
fnp-6316	125	9	findings	finding	NOUN
fnp-6316	125	10	,	,	PUNCT
fnp-6316	125	11	a	a	DET
fnp-6316	125	12	publicly	publicly	ADV
fnp-6316	125	13	accessible	accessible	ADJ
fnp-6316	125	14	interactive	interactive	ADJ
fnp-6316	125	15	online	online	ADJ
fnp-6316	125	16	platform	platform	NOUN
fnp-6316	125	17	is	be	AUX
fnp-6316	125	18	available	available	ADJ
fnp-6316	125	19	:	:	PUNCT
fnp-6316	125	20	https://3d-gbms.shin	https://3d-gbms.shin	AUX
fnp-6316	125	21	yapps.io/search/.	yapps.io/search/.	PROPN
fnp-6316	125	22	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	125	23	free	free	ADJ
fnp-6316	125	24	neuropathology	neuropathology	NOUN
fnp-6316	125	25	6:10	6:10	NUM
fnp-6316	125	26	(	(	PUNCT
fnp-6316	125	27	2025	2025	NUM
fnp-6316	125	28	)	)	PUNCT
fnp-6316	125	29	michel	michel	PROPN
fnp-6316	125	30	mittelbronn	mittelbronn	PROPN
fnp-6316	125	31	doi	doi	PROPN
fnp-6316	125	32	:	:	PUNCT
fnp-6316	125	33	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	125	34	page	page	NOUN
fnp-6316	125	35	8	8	NUM
fnp-6316	125	36	of	of	ADP
fnp-6316	125	37	19	19	NUM
fnp-6316	125	38	figure	figure	NOUN
fnp-6316	125	39	 	 	SPACE
fnp-6316	125	40	4	4	NUM
fnp-6316	125	41	:	:	PUNCT
fnp-6316	125	42	3d	3d	NUM
fnp-6316	125	43	glioblastoma	glioblastoma	NOUN
fnp-6316	125	44	evolution	evolution	NOUN
fnp-6316	125	45	and	and	CCONJ
fnp-6316	125	46	heterogeneity	heterogeneity	NOUN
fnp-6316	125	47	:	:	PUNCT
fnp-6316	125	48	methodological	methodological	ADJ
fnp-6316	125	49	approach	approach	NOUN
fnp-6316	125	50	and	and	CCONJ
fnp-6316	125	51	key	key	ADJ
fnp-6316	125	52	findings	finding	NOUN
fnp-6316	125	53	.	.	PUNCT
fnp-6316	126	1	abbreviations	abbreviation	NOUN
fnp-6316	126	2	:	:	PUNCT
fnp-6316	126	3	org	org	ADJ
fnp-6316	126	4	:	:	PUNCT
fnp-6316	126	5	outer	outer	ADJ
fnp-6316	126	6	radial	radial	ADJ
fnp-6316	126	7	glia	glia	NOUN
fnp-6316	126	8	;	;	PUNCT
fnp-6316	126	9	ipc	ipc	PROPN
fnp-6316	126	10	:	:	PUNCT
fnp-6316	126	11	intermediate	intermediate	ADJ
fnp-6316	126	12	progenitor	progenitor	NOUN
fnp-6316	126	13	cell	cell	NOUN
fnp-6316	126	14	;	;	PUNCT
fnp-6316	126	15	opc	opc	PROPN
fnp-6316	126	16	:	:	PUNCT
fnp-6316	126	17	oligodendrocyte	oligodendrocyte	ADJ
fnp-6316	126	18	precursor	precursor	NOUN
fnp-6316	126	19	cell	cell	NOUN
fnp-6316	126	20	;	;	PUNCT
fnp-6316	126	21	neurod1	neurod1	NOUN
fnp-6316	126	22	:	:	PUNCT
fnp-6316	126	23	neuronal	neuronal	ADJ
fnp-6316	126	24	differentiation	differentiation	NOUN
fnp-6316	126	25	1	1	NUM
fnp-6316	126	26	(	(	PUNCT
fnp-6316	126	27	transcription	transcription	NOUN
fnp-6316	126	28	factor	factor	NOUN
fnp-6316	126	29	)	)	PUNCT
fnp-6316	126	30	;	;	PUNCT
fnp-6316	126	31	ap-1	ap-1	ADV
fnp-6316	126	32	:	:	PUNCT
fnp-6316	126	33	activator	activator	NOUN
fnp-6316	126	34	protein	protein	NOUN
fnp-6316	126	35	1	1	NUM
fnp-6316	126	36	(	(	PUNCT
fnp-6316	126	37	transcription	transcription	NOUN
fnp-6316	126	38	factor	factor	NOUN
fnp-6316	126	39	)	)	PUNCT
fnp-6316	126	40	.	.	PUNCT
fnp-6316	127	1	5	5	X
fnp-6316	127	2	.	.	X
fnp-6316	127	3	cranioencephalic	cranioencephalic	ADJ
fnp-6316	127	4	functional	functional	ADJ
fnp-6316	127	5	lymphoid	lymphoid	ADJ
fnp-6316	127	6	units	unit	NOUN
fnp-6316	127	7	in	in	ADP
fnp-6316	127	8	glioblastoma	glioblastoma	NOUN
fnp-6316	127	9	[	[	X
fnp-6316	127	10	dobersalske	dobersalske	PROPN
fnp-6316	127	11	et	et	PROPN
fnp-6316	127	12	al	al	PROPN
fnp-6316	127	13	.	.	PROPN
fnp-6316	127	14	,	,	PUNCT
fnp-6316	127	15	2024	2024	NUM
fnp-6316	127	16	]	]	PUNCT
fnp-6316	127	17	bridging	bridging	NOUN
fnp-6316	127	18	veins	vein	NOUN
fnp-6316	127	19	allow	allow	VERB
fnp-6316	127	20	for	for	ADP
fnp-6316	127	21	an	an	DET
fnp-6316	127	22	immunological	immunological	ADJ
fnp-6316	127	23	communication	communication	NOUN
fnp-6316	127	24	between	between	ADP
fnp-6316	127	25	cns	cns	PROPN
fnp-6316	127	26	and	and	CCONJ
fnp-6316	127	27	skull	skull	NOUN
fnp-6316	127	28	bone	bone	NOUN
fnp-6316	127	29	marrow	marrow	NOUN
fnp-6316	127	30	crossing	cross	VERB
fnp-6316	127	31	the	the	DET
fnp-6316	127	32	arachnoid	arachnoid	NOUN
fnp-6316	127	33	barrier	barrier	NOUN
fnp-6316	127	34	by	by	ADP
fnp-6316	127	35	connecting	connect	VERB
fnp-6316	127	36	cns	cns	NOUN
fnp-6316	127	37	blood	blood	NOUN
fnp-6316	127	38	vessels	vessel	NOUN
fnp-6316	127	39	with	with	ADP
fnp-6316	127	40	the	the	DET
fnp-6316	127	41	meningeal	meningeal	ADJ
fnp-6316	127	42	blood	blood	NOUN
fnp-6316	127	43	circulation	circulation	NOUN
fnp-6316	127	44	and	and	CCONJ
fnp-6316	127	45	finally	finally	ADV
fnp-6316	127	46	the	the	DET
fnp-6316	127	47	sinusoidal	sinusoidal	ADJ
fnp-6316	127	48	vasculature	vasculature	NOUN
fnp-6316	127	49	of	of	ADP
fnp-6316	127	50	the	the	DET
fnp-6316	127	51	bone	bone	NOUN
fnp-6316	127	52	marrow	marrow	NOUN
fnp-6316	128	1	[	[	X
fnp-6316	128	2	smyth	smyth	PROPN
fnp-6316	128	3	et	et	PROPN
fnp-6316	128	4	al	al	PROPN
fnp-6316	128	5	.	.	PROPN
fnp-6316	128	6	,	,	PUNCT
fnp-6316	128	7	2024	2024	NUM
fnp-6316	128	8	]	]	PUNCT
fnp-6316	128	9	.	.	PUNCT
fnp-6316	129	1	as	as	SCONJ
fnp-6316	129	2	hematopoietic	hematopoietic	ADJ
fnp-6316	129	3	stem	stem	NOUN
fnp-6316	129	4	and	and	CCONJ
fnp-6316	129	5	progenitor	progenitor	NOUN
fnp-6316	129	6	cells	cell	NOUN
fnp-6316	129	7	are	be	AUX
fnp-6316	129	8	located	locate	VERB
fnp-6316	129	9	in	in	ADP
fnp-6316	129	10	the	the	DET
fnp-6316	129	11	skull	skull	NOUN
fnp-6316	129	12	bone	bone	NOUN
fnp-6316	129	13	marrow	marrow	NOUN
fnp-6316	129	14	,	,	PUNCT
fnp-6316	129	15	however	however	ADV
fnp-6316	129	16	not	not	PART
fnp-6316	129	17	well	well	ADV
fnp-6316	129	18	studied	study	VERB
fnp-6316	129	19	in	in	ADP
fnp-6316	129	20	the	the	DET
fnp-6316	129	21	context	context	NOUN
fnp-6316	129	22	of	of	ADP
fnp-6316	129	23	human	human	ADJ
fnp-6316	129	24	diseases	disease	NOUN
fnp-6316	129	25	,	,	PUNCT
fnp-6316	129	26	dobersalske	dobersalske	PROPN
fnp-6316	129	27	et	et	PROPN
fnp-6316	129	28	al	al	PROPN
fnp-6316	129	29	.	.	PROPN
fnp-6316	130	1	intended	intend	VERB
fnp-6316	130	2	to	to	PART
fnp-6316	130	3	assess	assess	VERB
fnp-6316	130	4	the	the	DET
fnp-6316	130	5	immune	immune	ADJ
fnp-6316	130	6	cell	cell	NOUN
fnp-6316	130	7	properties	property	NOUN
fnp-6316	130	8	in	in	ADP
fnp-6316	130	9	those	those	DET
fnp-6316	130	10	areas	area	NOUN
fnp-6316	130	11	in	in	ADP
fnp-6316	130	12	regional	regional	ADJ
fnp-6316	130	13	proximity	proximity	NOUN
fnp-6316	130	14	to	to	ADP
fnp-6316	130	15	human	human	ADJ
fnp-6316	130	16	glioblastoma	glioblastoma	NOUN
fnp-6316	130	17	,	,	PUNCT
fnp-6316	130	18	a	a	DET
fnp-6316	130	19	condition	condition	NOUN
fnp-6316	130	20	known	know	VERB
fnp-6316	130	21	for	for	ADP
fnp-6316	130	22	its	its	PRON
fnp-6316	130	23	highly	highly	ADV
fnp-6316	130	24	immunosuppressive	immunosuppressive	ADJ
fnp-6316	130	25	nature	nature	NOUN
fnp-6316	130	26	[	[	X
fnp-6316	130	27	dobersalske	dobersalske	PROPN
fnp-6316	130	28	et	et	PROPN
fnp-6316	130	29	al	al	PROPN
fnp-6316	130	30	.	.	PROPN
fnp-6316	130	31	,	,	PUNCT
fnp-6316	130	32	2024	2024	NUM
fnp-6316	130	33	]	]	PUNCT
fnp-6316	130	34	.	.	PUNCT
fnp-6316	131	1	using	use	VERB
fnp-6316	131	2	a	a	DET
fnp-6316	131	3	cxcl12	cxcl12	ADJ
fnp-6316	131	4	analog	analog	NOUN
fnp-6316	131	5	radioligand	radioligand	NOUN
fnp-6316	131	6	tracer	tracer	NOUN
fnp-6316	131	7	for	for	ADP
fnp-6316	131	8	cxcr4	cxcr4	NOUN
fnp-6316	131	9	,	,	PUNCT
fnp-6316	131	10	a	a	DET
fnp-6316	131	11	marker	marker	NOUN
fnp-6316	131	12	for	for	ADP
fnp-6316	131	13	hematopoietic	hematopoietic	ADJ
fnp-6316	131	14	and	and	CCONJ
fnp-6316	131	15	immune	immune	ADJ
fnp-6316	131	16	cells	cell	NOUN
fnp-6316	131	17	,	,	PUNCT
fnp-6316	131	18	the	the	DET
fnp-6316	131	19	authors	author	NOUN
fnp-6316	131	20	found	find	VERB
fnp-6316	131	21	surprisingly	surprisingly	ADV
fnp-6316	131	22	high	high	ADJ
fnp-6316	131	23	activity	activity	NOUN
fnp-6316	131	24	in	in	ADP
fnp-6316	131	25	the	the	DET
fnp-6316	131	26	ipsilateral	ipsilateral	ADJ
fnp-6316	131	27	skull	skull	NOUN
fnp-6316	131	28	bone	bone	NOUN
fnp-6316	131	29	marrow	marrow	NOUN
fnp-6316	131	30	and	and	CCONJ
fnp-6316	131	31	meninges	meninge	NOUN
fnp-6316	131	32	related	relate	VERB
fnp-6316	131	33	to	to	ADP
fnp-6316	131	34	the	the	DET
fnp-6316	131	35	glioblastoma	glioblastoma	NOUN
fnp-6316	131	36	localization	localization	NOUN
fnp-6316	131	37	in	in	ADP
fnp-6316	131	38	usually	usually	ADV
fnp-6316	131	39	older	old	ADJ
fnp-6316	131	40	glioblastoma	glioblastoma	NOUN
fnp-6316	131	41	patients	patient	NOUN
fnp-6316	131	42	.	.	PUNCT
fnp-6316	132	1	in	in	ADP
fnp-6316	132	2	a	a	DET
fnp-6316	132	3	single	single	ADJ
fnp-6316	132	4	-	-	PUNCT
fnp-6316	132	5	cell	cell	NOUN
fnp-6316	132	6	rna	rna	NOUN
fnp-6316	132	7	sequencing	sequence	VERB
fnp-6316	132	8	approach	approach	NOUN
fnp-6316	132	9	from	from	ADP
fnp-6316	132	10	corresponding	correspond	VERB
fnp-6316	132	11	(	(	PUNCT
fnp-6316	132	12	a	a	PRON
fnp-6316	132	13	)	)	PUNCT
fnp-6316	132	14	glioblastoma	glioblastoma	NOUN
fnp-6316	132	15	samples	sample	NOUN
fnp-6316	132	16	,	,	PUNCT
fnp-6316	132	17	(	(	PUNCT
fnp-6316	132	18	b	b	X
fnp-6316	132	19	)	)	PUNCT
fnp-6316	132	20	ipsilateral	ipsilateral	ADJ
fnp-6316	132	21	bone	bone	NOUN
fnp-6316	132	22	marrow	marrow	NOUN
fnp-6316	132	23	of	of	ADP
fnp-6316	132	24	the	the	DET
fnp-6316	132	25	skull	skull	NOUN
fnp-6316	132	26	,	,	PUNCT
fnp-6316	132	27	(	(	PUNCT
fnp-6316	132	28	c	c	NOUN
fnp-6316	132	29	)	)	PUNCT
fnp-6316	132	30	peripheral	peripheral	ADJ
fnp-6316	132	31	blood	blood	NOUN
fnp-6316	132	32	mononuclear	mononuclear	ADJ
fnp-6316	132	33	cells	cell	NOUN
fnp-6316	132	34	(	(	PUNCT
fnp-6316	132	35	pbmcs	pbmcs	NOUN
fnp-6316	132	36	)	)	PUNCT
fnp-6316	132	37	and	and	CCONJ
fnp-6316	132	38	(	(	PUNCT
fnp-6316	132	39	d	d	X
fnp-6316	132	40	)	)	PUNCT
fnp-6316	132	41	distal	distal	ADJ
fnp-6316	132	42	hip	hip	NOUN
fnp-6316	132	43	bone	bone	NOUN
fnp-6316	132	44	marrow	marrow	NOUN
fnp-6316	132	45	,	,	PUNCT
fnp-6316	132	46	considerable	considerable	ADJ
fnp-6316	132	47	differences	difference	NOUN
fnp-6316	132	48	in	in	ADP
fnp-6316	132	49	immune	immune	ADJ
fnp-6316	132	50	cell	cell	NOUN
fnp-6316	132	51	compositions	composition	NOUN
fnp-6316	132	52	were	be	AUX
fnp-6316	132	53	found	find	VERB
fnp-6316	132	54	.	.	PUNCT
fnp-6316	133	1	regarding	regard	VERB
fnp-6316	133	2	the	the	DET
fnp-6316	133	3	myeloid	myeloid	ADJ
fnp-6316	133	4	cell	cell	NOUN
fnp-6316	133	5	compartment	compartment	NOUN
fnp-6316	133	6	,	,	PUNCT
fnp-6316	133	7	mostly	mostly	ADV
fnp-6316	133	8	naïve	naïve	ADJ
fnp-6316	133	9	monocytes	monocyte	NOUN
fnp-6316	133	10	were	be	AUX
fnp-6316	133	11	found	find	VERB
fnp-6316	133	12	the	the	DET
fnp-6316	133	13	ipsilateral	ipsilateral	ADJ
fnp-6316	133	14	skull	skull	NOUN
fnp-6316	133	15	bone	bone	NOUN
fnp-6316	133	16	marrow	marrow	NOUN
fnp-6316	133	17	contrasting	contrast	VERB
fnp-6316	133	18	anti	anti	ADJ
fnp-6316	133	19	-	-	ADJ
fnp-6316	133	20	inflammatory	inflammatory	ADJ
fnp-6316	133	21	monocytes	monocyte	NOUN
fnp-6316	133	22	and	and	CCONJ
fnp-6316	133	23	macrophages	macrophage	NOUN
fnp-6316	133	24	,	,	PUNCT
fnp-6316	133	25	predominantly	predominantly	ADV
fnp-6316	133	26	found	find	VERB
fnp-6316	133	27	within	within	ADP
fnp-6316	133	28	glioblastoma	glioblastoma	NOUN
fnp-6316	133	29	.	.	PUNCT
fnp-6316	134	1	of	of	ADP
fnp-6316	134	2	note	note	NOUN
fnp-6316	134	3	,	,	PUNCT
fnp-6316	134	4	a	a	DET
fnp-6316	134	5	strong	strong	ADJ
fnp-6316	134	6	accumulation	accumulation	NOUN
fnp-6316	134	7	of	of	ADP
fnp-6316	134	8	effector	effector	NOUN
fnp-6316	134	9	-	-	PUNCT
fnp-6316	134	10	type	type	NOUN
fnp-6316	134	11	,	,	PUNCT
fnp-6316	134	12	glioma	glioma	NOUN
fnp-6316	134	13	-	-	PUNCT
fnp-6316	134	14	reactive	reactive	NOUN
fnp-6316	134	15	cd8	cd8	PROPN
fnp-6316	134	16	+	+	PROPN
fnp-6316	134	17	t	t	NOUN
fnp-6316	134	18	cell	cell	NOUN
fnp-6316	134	19	activity	activity	NOUN
fnp-6316	134	20	was	be	AUX
fnp-6316	134	21	detected	detect	VERB
fnp-6316	134	22	in	in	ADP
fnp-6316	134	23	the	the	DET
fnp-6316	134	24	skull	skull	NOUN
fnp-6316	134	25	of	of	ADP
fnp-6316	134	26	ipsilateral	ipsilateral	ADJ
fnp-6316	134	27	bone	bone	NOUN
fnp-6316	134	28	marrow	marrow	NOUN
fnp-6316	134	29	whereas	whereas	SCONJ
fnp-6316	134	30	a	a	DET
fnp-6316	134	31	lower	low	ADJ
fnp-6316	134	32	activity	activity	NOUN
fnp-6316	134	33	was	be	AUX
fnp-6316	134	34	found	find	VERB
fnp-6316	134	35	in	in	ADP
fnp-6316	134	36	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	134	37	free	free	ADJ
fnp-6316	134	38	neuropathology	neuropathology	NOUN
fnp-6316	134	39	6:10	6:10	NUM
fnp-6316	134	40	(	(	PUNCT
fnp-6316	134	41	2025	2025	NUM
fnp-6316	134	42	)	)	PUNCT
fnp-6316	134	43	michel	michel	PROPN
fnp-6316	134	44	mittelbronn	mittelbronn	PROPN
fnp-6316	134	45	doi	doi	PROPN
fnp-6316	134	46	:	:	PUNCT
fnp-6316	134	47	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	134	48	page	page	NOUN
fnp-6316	134	49	9	9	NUM
fnp-6316	134	50	of	of	ADP
fnp-6316	134	51	19	19	NUM
fnp-6316	134	52	figure	figure	NOUN
fnp-6316	134	53	 	 	SPACE
fnp-6316	134	54	5	5	NUM
fnp-6316	134	55	:	:	PUNCT
fnp-6316	134	56	cranioencephalic	cranioencephalic	ADJ
fnp-6316	134	57	functional	functional	ADJ
fnp-6316	134	58	lymphoid	lymphoid	ADJ
fnp-6316	134	59	units	unit	NOUN
fnp-6316	134	60	in	in	ADP
fnp-6316	134	61	glioblastoma	glioblastoma	NOUN
fnp-6316	134	62	.	.	PUNCT
fnp-6316	135	1	left	leave	VERB
fnp-6316	135	2	side	side	NOUN
fnp-6316	135	3	:	:	PUNCT
fnp-6316	135	4	methodological	methodological	ADJ
fnp-6316	135	5	set	set	NOUN
fnp-6316	135	6	-	-	PUNCT
fnp-6316	135	7	up	up	NOUN
fnp-6316	135	8	.	.	PUNCT
fnp-6316	136	1	right	right	ADJ
fnp-6316	136	2	side	side	NOUN
fnp-6316	136	3	:	:	PUNCT
fnp-6316	136	4	major	major	ADJ
fnp-6316	136	5	findings	finding	NOUN
fnp-6316	136	6	according	accord	VERB
fnp-6316	136	7	to	to	ADP
fnp-6316	136	8	compartment	compartment	NOUN
fnp-6316	136	9	.	.	PUNCT
fnp-6316	137	1	intratumor	intratumor	PROPN
fnp-6316	137	2	cd8	cd8	PROPN
fnp-6316	137	3	+	+	PROPN
fnp-6316	137	4	t	t	NOUN
fnp-6316	137	5	cells	cell	NOUN
fnp-6316	137	6	.	.	PUNCT
fnp-6316	138	1	both	both	DET
fnp-6316	138	2	cd8	cd8	PROPN
fnp-6316	138	3	+	+	PROPN
fnp-6316	138	4	t	t	NOUN
fnp-6316	138	5	cells	cell	NOUN
fnp-6316	138	6	from	from	ADP
fnp-6316	138	7	pbmcs	pbmcs	NOUN
fnp-6316	138	8	and	and	CCONJ
fnp-6316	138	9	ipsilateral	ipsilateral	ADJ
fnp-6316	138	10	bone	bone	NOUN
fnp-6316	138	11	marrow	marrow	NOUN
fnp-6316	138	12	were	be	AUX
fnp-6316	138	13	able	able	ADJ
fnp-6316	138	14	to	to	PART
fnp-6316	138	15	experimentally	experimentally	ADV
fnp-6316	138	16	reproduce	reproduce	VERB
fnp-6316	138	17	memory	memory	NOUN
fnp-6316	138	18	and	and	CCONJ
fnp-6316	138	19	effector	effector	NOUN
fnp-6316	138	20	t	t	NOUN
fnp-6316	138	21	cells	cell	NOUN
fnp-6316	138	22	,	,	PUNCT
fnp-6316	138	23	while	while	SCONJ
fnp-6316	138	24	intratumor	intratumor	PROPN
fnp-6316	138	25	t	t	PROPN
fnp-6316	138	26	cells	cell	NOUN
fnp-6316	138	27	failed	fail	VERB
fnp-6316	138	28	.	.	PUNCT
fnp-6316	139	1	of	of	ADP
fnp-6316	139	2	note	note	NOUN
fnp-6316	139	3	,	,	PUNCT
fnp-6316	139	4	the	the	DET
fnp-6316	139	5	antitumoral	antitumoral	ADJ
fnp-6316	139	6	activity	activity	NOUN
fnp-6316	139	7	of	of	ADP
fnp-6316	139	8	skull	skull	NOUN
fnp-6316	139	9	bone	bone	NOUN
fnp-6316	139	10	marrow	marrow	PROPN
fnp-6316	139	11	derived	derive	VERB
fnp-6316	139	12	cd8	cd8	PROPN
fnp-6316	139	13	+	+	PROPN
fnp-6316	139	14	t	t	PROPN
fnp-6316	139	15	cells	cell	NOUN
fnp-6316	139	16	was	be	AUX
fnp-6316	139	17	higher	high	ADJ
fnp-6316	139	18	compared	compare	VERB
fnp-6316	139	19	to	to	ADP
fnp-6316	139	20	counterparts	counterpart	NOUN
fnp-6316	139	21	derived	derive	VERB
fnp-6316	139	22	from	from	ADP
fnp-6316	139	23	pbmcs	pbmcs	NOUN
fnp-6316	139	24	,	,	PUNCT
fnp-6316	139	25	distal	distal	ADJ
fnp-6316	139	26	hip	hip	NOUN
fnp-6316	139	27	bone	bone	NOUN
fnp-6316	139	28	marrow	marrow	NOUN
fnp-6316	139	29	or	or	CCONJ
fnp-6316	139	30	the	the	DET
fnp-6316	139	31	glioblastoma	glioblastoma	NOUN
fnp-6316	139	32	microenvironment	microenvironment	NOUN
fnp-6316	139	33	.	.	PUNCT
fnp-6316	140	1	similarly	similarly	ADV
fnp-6316	140	2	high	high	ADJ
fnp-6316	140	3	frequencies	frequency	NOUN
fnp-6316	140	4	of	of	ADP
fnp-6316	140	5	tumor	tumor	NOUN
fnp-6316	140	6	-	-	PUNCT
fnp-6316	140	7	reactive	reactive	NOUN
fnp-6316	140	8	t	t	NOUN
fnp-6316	140	9	cells	cell	NOUN
fnp-6316	140	10	were	be	AUX
fnp-6316	140	11	found	find	VERB
fnp-6316	140	12	in	in	ADP
fnp-6316	140	13	skull	skull	NOUN
fnp-6316	140	14	bone	bone	NOUN
fnp-6316	140	15	marrow	marrow	NOUN
fnp-6316	140	16	compared	compare	VERB
fnp-6316	140	17	to	to	ADP
fnp-6316	140	18	the	the	DET
fnp-6316	140	19	intratumor	intratumor	PROPN
fnp-6316	140	20	microenvironment	microenvironment	NOUN
fnp-6316	140	21	,	,	PUNCT
fnp-6316	140	22	indicating	indicate	VERB
fnp-6316	140	23	an	an	DET
fnp-6316	140	24	immune	immune	ADJ
fnp-6316	140	25	cell	cell	NOUN
fnp-6316	140	26	trafficking	trafficking	NOUN
fnp-6316	140	27	between	between	ADP
fnp-6316	140	28	both	both	DET
fnp-6316	140	29	compartments	compartment	NOUN
fnp-6316	140	30	.	.	PUNCT
fnp-6316	141	1	using	use	VERB
fnp-6316	141	2	the	the	DET
fnp-6316	141	3	aforementioned	aforementioned	ADJ
fnp-6316	141	4	radioligand	radioligand	NOUN
fnp-6316	141	5	tracer	tracer	NOUN
fnp-6316	141	6	,	,	PUNCT
fnp-6316	141	7	a	a	DET
fnp-6316	141	8	significantly	significantly	ADV
fnp-6316	141	9	longer	long	ADJ
fnp-6316	141	10	survival	survival	NOUN
fnp-6316	141	11	benefit	benefit	NOUN
fnp-6316	141	12	for	for	ADP
fnp-6316	141	13	glioblastoma	glioblastoma	NOUN
fnp-6316	141	14	patients	patient	NOUN
fnp-6316	141	15	with	with	ADP
fnp-6316	141	16	stronger	strong	ADJ
fnp-6316	141	17	intratumor	intratumor	NOUN
fnp-6316	141	18	and	and	CCONJ
fnp-6316	141	19	skull	skull	NOUN
fnp-6316	141	20	bone	bone	NOUN
fnp-6316	141	21	marrow	marrow	PROPN
fnp-6316	141	22	immune	immune	ADJ
fnp-6316	141	23	cell	cell	NOUN
fnp-6316	141	24	activity	activity	NOUN
fnp-6316	141	25	was	be	AUX
fnp-6316	141	26	observed	observe	VERB
fnp-6316	141	27	already	already	ADV
fnp-6316	141	28	in	in	ADP
fnp-6316	141	29	a	a	DET
fnp-6316	141	30	relatively	relatively	ADV
fnp-6316	141	31	small	small	ADJ
fnp-6316	141	32	patient	patient	ADJ
fnp-6316	141	33	cohort	cohort	NOUN
fnp-6316	141	34	(	(	PUNCT
fnp-6316	141	35	n	n	CCONJ
fnp-6316	141	36	 	 	SPACE
fnp-6316	141	37	=	=	NOUN
fnp-6316	141	38	 	 	SPACE
fnp-6316	141	39	52	52	NUM
fnp-6316	141	40	)	)	PUNCT
fnp-6316	141	41	.	.	PUNCT
fnp-6316	142	1	taking	take	VERB
fnp-6316	142	2	the	the	DET
fnp-6316	142	3	clinical	clinical	ADJ
fnp-6316	142	4	impact	impact	NOUN
fnp-6316	142	5	into	into	ADP
fnp-6316	142	6	account	account	NOUN
fnp-6316	142	7	,	,	PUNCT
fnp-6316	142	8	these	these	DET
fnp-6316	142	9	findings	finding	NOUN
fnp-6316	142	10	imply	imply	VERB
fnp-6316	142	11	that	that	SCONJ
fnp-6316	142	12	the	the	DET
fnp-6316	142	13	skull	skull	NOUN
fnp-6316	142	14	bone	bone	NOUN
fnp-6316	142	15	marrow	marrow	PROPN
fnp-6316	142	16	immune	immune	ADJ
fnp-6316	142	17	cell	cell	NOUN
fnp-6316	142	18	niches	niche	NOUN
fnp-6316	142	19	should	should	AUX
fnp-6316	142	20	be	be	AUX
fnp-6316	142	21	absolutely	absolutely	ADV
fnp-6316	142	22	protected	protect	VERB
fnp-6316	142	23	during	during	ADP
fnp-6316	142	24	neurosurgical	neurosurgical	ADJ
fnp-6316	142	25	and	and	CCONJ
fnp-6316	142	26	subsequent	subsequent	ADJ
fnp-6316	142	27	radiotherapeutic	radiotherapeutic	ADJ
fnp-6316	142	28	intervention	intervention	NOUN
fnp-6316	142	29	.	.	PUNCT
fnp-6316	143	1	in	in	ADP
fnp-6316	143	2	summary	summary	NOUN
fnp-6316	143	3	,	,	PUNCT
fnp-6316	143	4	dobersalske	dobersalske	PROPN
fnp-6316	143	5	et	et	PROPN
fnp-6316	143	6	al	al	PROPN
fnp-6316	143	7	.	.	PROPN
fnp-6316	143	8	shed	shed	VERB
fnp-6316	143	9	a	a	DET
fnp-6316	143	10	new	new	ADJ
fnp-6316	143	11	light	light	NOUN
fnp-6316	143	12	of	of	ADP
fnp-6316	143	13	the	the	DET
fnp-6316	143	14	local	local	ADJ
fnp-6316	143	15	antitumoral	antitumoral	ADJ
fnp-6316	143	16	immune	immune	ADJ
fnp-6316	143	17	cell	cell	NOUN
fnp-6316	143	18	activities	activity	NOUN
fnp-6316	143	19	in	in	ADP
fnp-6316	143	20	glioblastoma	glioblastoma	NOUN
fnp-6316	143	21	patients	patient	NOUN
fnp-6316	143	22	that	that	PRON
fnp-6316	143	23	needs	need	VERB
fnp-6316	143	24	to	to	PART
fnp-6316	143	25	be	be	AUX
fnp-6316	143	26	considered	consider	VERB
fnp-6316	143	27	for	for	ADP
fnp-6316	143	28	future	future	ADJ
fnp-6316	143	29	immunotherapies	immunotherapy	NOUN
fnp-6316	143	30	(	(	PUNCT
fnp-6316	143	31	for	for	ADP
fnp-6316	143	32	summary	summary	NOUN
fnp-6316	143	33	,	,	PUNCT
fnp-6316	143	34	see	see	VERB
fnp-6316	143	35	figure	figure	NOUN
fnp-6316	143	36	 	 	SPACE
fnp-6316	143	37	5	5	NUM
fnp-6316	143	38	)	)	PUNCT
fnp-6316	143	39	.	.	PUNCT
fnp-6316	144	1	6	6	X
fnp-6316	144	2	.	.	X
fnp-6316	144	3	prognosis	prognosis	NOUN
fnp-6316	144	4	prediction	prediction	NOUN
fnp-6316	144	5	via	via	ADP
fnp-6316	144	6	histomorphological	histomorphological	ADJ
fnp-6316	144	7	features	feature	NOUN
fnp-6316	144	8	in	in	ADP
fnp-6316	144	9	glioblastoma	glioblastoma	NOUN
fnp-6316	144	10	[	[	X
fnp-6316	144	11	kirishima	kirishima	X
fnp-6316	144	12	et	et	PROPN
fnp-6316	144	13	al	al	PROPN
fnp-6316	144	14	.	.	PROPN
fnp-6316	144	15	,	,	PUNCT
fnp-6316	144	16	2024	2024	NUM
fnp-6316	144	17	]	]	PUNCT
fnp-6316	144	18	neuropathological	neuropathological	ADJ
fnp-6316	144	19	tumor	tumor	NOUN
fnp-6316	144	20	diagnostics	diagnostic	NOUN
fnp-6316	144	21	is	be	AUX
fnp-6316	144	22	more	more	ADV
fnp-6316	144	23	and	and	CCONJ
fnp-6316	144	24	more	more	ADV
fnp-6316	144	25	shifting	shift	VERB
fnp-6316	144	26	away	away	ADV
fnp-6316	144	27	from	from	ADP
fnp-6316	144	28	the	the	DET
fnp-6316	144	29	previous	previous	ADJ
fnp-6316	144	30	gold	gold	NOUN
fnp-6316	144	31	standard	standard	NOUN
fnp-6316	144	32	of	of	ADP
fnp-6316	144	33	microscopic	microscopic	ADJ
fnp-6316	144	34	analysis	analysis	NOUN
fnp-6316	144	35	to	to	ADP
fnp-6316	144	36	more	more	ADV
fnp-6316	144	37	unbiased	unbiased	ADJ
fnp-6316	144	38	molecular	molecular	ADJ
fnp-6316	144	39	methods	method	NOUN
fnp-6316	144	40	mostly	mostly	ADV
fnp-6316	144	41	including	include	VERB
fnp-6316	144	42	genetic	genetic	ADJ
fnp-6316	144	43	and	and	CCONJ
fnp-6316	144	44	epigenetic	epigenetic	ADJ
fnp-6316	144	45	assessment	assessment	NOUN
fnp-6316	144	46	for	for	ADP
fnp-6316	144	47	both	both	CCONJ
fnp-6316	144	48	diagnostic	diagnostic	ADJ
fnp-6316	144	49	precision	precision	NOUN
fnp-6316	144	50	as	as	ADV
fnp-6316	144	51	well	well	ADV
fnp-6316	144	52	as	as	ADP
fnp-6316	144	53	prediction	prediction	NOUN
fnp-6316	144	54	for	for	ADP
fnp-6316	144	55	treatment	treatment	NOUN
fnp-6316	144	56	response	response	NOUN
fnp-6316	144	57	and	and	CCONJ
fnp-6316	144	58	patient	patient	ADJ
fnp-6316	144	59	survival	survival	NOUN
fnp-6316	144	60	.	.	PUNCT
fnp-6316	145	1	as	as	SCONJ
fnp-6316	145	2	molecular	molecular	ADJ
fnp-6316	145	3	,	,	PUNCT
fnp-6316	145	4	especially	especially	ADV
fnp-6316	145	5	epigenetic	epigenetic	ADJ
fnp-6316	145	6	features	feature	NOUN
fnp-6316	145	7	seem	seem	VERB
fnp-6316	145	8	to	to	PART
fnp-6316	145	9	be	be	AUX
fnp-6316	145	10	more	more	ADV
fnp-6316	145	11	stable	stable	ADJ
fnp-6316	145	12	than	than	ADP
fnp-6316	145	13	the	the	DET
fnp-6316	145	14	highly	highly	ADV
fnp-6316	145	15	variable	variable	ADJ
fnp-6316	145	16	morphological	morphological	ADJ
fnp-6316	145	17	features	feature	NOUN
fnp-6316	145	18	in	in	ADP
fnp-6316	145	19	glioblastoma	glioblastoma	NOUN
fnp-6316	145	20	,	,	PUNCT
fnp-6316	145	21	it	it	PRON
fnp-6316	145	22	is	be	AUX
fnp-6316	145	23	extremely	extremely	ADV
fnp-6316	145	24	important	important	ADJ
fnp-6316	145	25	to	to	PART
fnp-6316	145	26	always	always	ADV
fnp-6316	145	27	sample	sample	VERB
fnp-6316	145	28	enough	enough	ADJ
fnp-6316	145	29	tissue	tissue	NOUN
fnp-6316	145	30	from	from	ADP
fnp-6316	145	31	all	all	DET
fnp-6316	145	32	different	different	ADJ
fnp-6316	145	33	tumor	tumor	NOUN
fnp-6316	145	34	areas	area	NOUN
fnp-6316	145	35	(	(	PUNCT
fnp-6316	145	36	e.g.	e.g.	ADV
fnp-6316	145	37	core	core	NOUN
fnp-6316	145	38	,	,	PUNCT
fnp-6316	145	39	periphery	periphery	NOUN
fnp-6316	145	40	,	,	PUNCT
fnp-6316	145	41	contrast	contrast	NOUN
fnp-6316	145	42	-	-	PUNCT
fnp-6316	145	43	enhancing	enhance	VERB
fnp-6316	145	44	areas	area	NOUN
fnp-6316	145	45	,	,	PUNCT
fnp-6316	145	46	necroses	necrose	NOUN
fnp-6316	145	47	etc	etc	X
fnp-6316	145	48	.	.	PUNCT
fnp-6316	145	49	)	)	PUNCT
fnp-6316	146	1	[	[	X
fnp-6316	146	2	mikkelsen	mikkelsen	X
fnp-6316	146	3	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	146	4	free	free	ADJ
fnp-6316	146	5	neuropathology	neuropathology	NOUN
fnp-6316	146	6	6:10	6:10	NUM
fnp-6316	146	7	(	(	PUNCT
fnp-6316	146	8	2025	2025	NUM
fnp-6316	146	9	)	)	PUNCT
fnp-6316	146	10	michel	michel	PROPN
fnp-6316	146	11	mittelbronn	mittelbronn	PROPN
fnp-6316	146	12	doi	doi	PROPN
fnp-6316	146	13	:	:	PUNCT
fnp-6316	146	14	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	146	15	page	page	NOUN
fnp-6316	146	16	10	10	NUM
fnp-6316	146	17	of	of	ADP
fnp-6316	146	18	19	19	NUM
fnp-6316	146	19	et	et	NOUN
fnp-6316	146	20	al	al	PROPN
fnp-6316	146	21	.	.	PROPN
fnp-6316	146	22	,	,	PUNCT
fnp-6316	146	23	2021	2021	NUM
fnp-6316	146	24	]	]	PUNCT
fnp-6316	146	25	.	.	PUNCT
fnp-6316	147	1	it	it	PRON
fnp-6316	147	2	is	be	AUX
fnp-6316	147	3	very	very	ADV
fnp-6316	147	4	interesting	interesting	ADJ
fnp-6316	147	5	for	for	ADP
fnp-6316	147	6	neuropathologists	neuropathologist	NOUN
fnp-6316	147	7	if	if	SCONJ
fnp-6316	147	8	complex	complex	ADJ
fnp-6316	147	9	histomorphological	histomorphological	ADJ
fnp-6316	147	10	assessments	assessment	NOUN
fnp-6316	147	11	can	can	AUX
fnp-6316	147	12	still	still	ADV
fnp-6316	147	13	compete	compete	VERB
fnp-6316	147	14	with	with	ADP
fnp-6316	147	15	modern	modern	ADJ
fnp-6316	147	16	molecular	molecular	ADJ
fnp-6316	147	17	diagnostics	diagnostic	NOUN
fnp-6316	147	18	.	.	PUNCT
fnp-6316	148	1	kirishima	kirishima	PROPN
fnp-6316	148	2	et	et	PROPN
fnp-6316	148	3	al	al	PROPN
fnp-6316	148	4	.	.	PROPN
fnp-6316	149	1	undertake	undertake	VERB
fnp-6316	149	2	the	the	DET
fnp-6316	149	3	endeavor	endeavor	NOUN
fnp-6316	149	4	to	to	PART
fnp-6316	149	5	explore	explore	VERB
fnp-6316	149	6	if	if	SCONJ
fnp-6316	149	7	distinct	distinct	ADJ
fnp-6316	149	8	morphological	morphological	ADJ
fnp-6316	149	9	features	feature	NOUN
fnp-6316	149	10	may	may	AUX
fnp-6316	149	11	still	still	ADV
fnp-6316	149	12	be	be	AUX
fnp-6316	149	13	of	of	ADP
fnp-6316	149	14	prognostic	prognostic	ADJ
fnp-6316	149	15	value	value	NOUN
fnp-6316	149	16	in	in	ADP
fnp-6316	149	17	glioblastoma	glioblastoma	NOUN
fnp-6316	149	18	.	.	PUNCT
fnp-6316	150	1	as	as	ADP
fnp-6316	150	2	for	for	ADP
fnp-6316	150	3	today	today	NOUN
fnp-6316	150	4	,	,	PUNCT
fnp-6316	150	5	a	a	DET
fnp-6316	150	6	few	few	ADJ
fnp-6316	150	7	studies	study	NOUN
fnp-6316	150	8	showed	show	VERB
fnp-6316	150	9	worst	bad	ADJ
fnp-6316	150	10	survival	survival	NOUN
fnp-6316	150	11	for	for	ADP
fnp-6316	150	12	some	some	DET
fnp-6316	150	13	glioblastoma	glioblastoma	NOUN
fnp-6316	150	14	subtypes	subtype	NOUN
fnp-6316	150	15	such	such	ADJ
fnp-6316	150	16	as	as	ADP
fnp-6316	150	17	epithelioid	epithelioid	NOUN
fnp-6316	150	18	or	or	CCONJ
fnp-6316	150	19	rhabdoid	rhabdoid	NOUN
fnp-6316	150	20	variants	variant	NOUN
fnp-6316	150	21	,	,	PUNCT
fnp-6316	150	22	no	no	DET
fnp-6316	150	23	unequivocally	unequivocally	ADV
fnp-6316	150	24	clear	clear	ADJ
fnp-6316	150	25	association	association	NOUN
fnp-6316	150	26	of	of	ADP
fnp-6316	150	27	any	any	DET
fnp-6316	150	28	specific	specific	ADJ
fnp-6316	150	29	morphological	morphological	ADJ
fnp-6316	150	30	phenotype	phenotype	NOUN
fnp-6316	150	31	with	with	ADP
fnp-6316	150	32	clinical	clinical	ADJ
fnp-6316	150	33	prognosis	prognosis	NOUN
fnp-6316	150	34	could	could	AUX
fnp-6316	150	35	be	be	AUX
fnp-6316	150	36	detected	detect	VERB
fnp-6316	151	1	[	[	X
fnp-6316	151	2	mallick	mallick	NOUN
fnp-6316	151	3	et	et	PROPN
fnp-6316	151	4	al	al	PROPN
fnp-6316	151	5	.	.	PROPN
fnp-6316	151	6	,	,	PUNCT
fnp-6316	151	7	2022	2022	NUM
fnp-6316	151	8	]	]	PUNCT
fnp-6316	151	9	.	.	PUNCT
fnp-6316	152	1	furthermore	furthermore	ADV
fnp-6316	152	2	,	,	PUNCT
fnp-6316	152	3	most	most	ADJ
fnp-6316	152	4	classical	classical	ADJ
fnp-6316	152	5	microscopic	microscopic	ADJ
fnp-6316	152	6	characteristics	characteristic	NOUN
fnp-6316	152	7	necessary	necessary	ADJ
fnp-6316	152	8	for	for	ADP
fnp-6316	152	9	the	the	DET
fnp-6316	152	10	diagnosis	diagnosis	NOUN
fnp-6316	152	11	of	of	ADP
fnp-6316	152	12	glioblastoma	glioblastoma	NOUN
fnp-6316	152	13	,	,	PUNCT
fnp-6316	152	14	such	such	ADJ
fnp-6316	152	15	as	as	ADP
fnp-6316	152	16	pseudopalisading	pseudopalisade	VERB
fnp-6316	152	17	necrosis	necrosis	NOUN
fnp-6316	152	18	or	or	CCONJ
fnp-6316	152	19	microvascular	microvascular	ADJ
fnp-6316	152	20	proliferations	proliferation	NOUN
fnp-6316	152	21	,	,	PUNCT
fnp-6316	152	22	are	be	AUX
fnp-6316	152	23	no	no	ADV
fnp-6316	152	24	longer	long	ADV
fnp-6316	152	25	sufficient	sufficient	ADJ
fnp-6316	152	26	for	for	ADP
fnp-6316	152	27	this	this	DET
fnp-6316	152	28	diagnosis	diagnosis	NOUN
fnp-6316	152	29	as	as	SCONJ
fnp-6316	152	30	they	they	PRON
fnp-6316	152	31	might	might	AUX
fnp-6316	152	32	also	also	ADV
fnp-6316	152	33	be	be	AUX
fnp-6316	152	34	found	find	VERB
fnp-6316	152	35	in	in	ADP
fnp-6316	152	36	idhmutant	idhmutant	ADJ
fnp-6316	152	37	astrocytoma	astrocytoma	NOUN
fnp-6316	152	38	[	[	X
fnp-6316	152	39	who	who	PRON
fnp-6316	152	40	classification	classification	NOUN
fnp-6316	152	41	of	of	ADP
fnp-6316	152	42	brain	brain	NOUN
fnp-6316	152	43	tumors	tumor	NOUN
fnp-6316	152	44	,	,	PUNCT
fnp-6316	152	45	2021	2021	NUM
fnp-6316	152	46	]	]	PUNCT
fnp-6316	152	47	.	.	PUNCT
fnp-6316	153	1	therefore	therefore	ADV
fnp-6316	153	2	,	,	PUNCT
fnp-6316	153	3	the	the	DET
fnp-6316	153	4	authors	author	NOUN
fnp-6316	153	5	of	of	ADP
fnp-6316	153	6	the	the	DET
fnp-6316	153	7	present	present	ADJ
fnp-6316	153	8	study	study	NOUN
fnp-6316	153	9	analyze	analyze	VERB
fnp-6316	153	10	227	227	NUM
fnp-6316	153	11	primary	primary	ADJ
fnp-6316	153	12	glioblastoma	glioblastoma	NOUN
fnp-6316	153	13	according	accord	VERB
fnp-6316	153	14	to	to	ADP
fnp-6316	153	15	the	the	PRON
fnp-6316	153	16	who	who	PRON
fnp-6316	153	17	criteria	criteria	VERB
fnp-6316	153	18	for	for	ADP
fnp-6316	153	19	the	the	DET
fnp-6316	153	20	classification	classification	NOUN
fnp-6316	153	21	of	of	ADP
fnp-6316	153	22	tumours	tumour	NOUN
fnp-6316	153	23	of	of	ADP
fnp-6316	153	24	the	the	DET
fnp-6316	153	25	central	central	ADJ
fnp-6316	153	26	nervous	nervous	ADJ
fnp-6316	153	27	system	system	NOUN
fnp-6316	153	28	from	from	ADP
fnp-6316	153	29	2021	2021	NUM
fnp-6316	153	30	and	and	CCONJ
fnp-6316	153	31	additionally	additionally	ADV
fnp-6316	153	32	assessed	assess	VERB
fnp-6316	153	33	the	the	DET
fnp-6316	153	34	following	follow	VERB
fnp-6316	153	35	microscopic	microscopic	ADJ
fnp-6316	153	36	features	feature	NOUN
fnp-6316	153	37	in	in	ADP
fnp-6316	153	38	10	10	NUM
fnp-6316	153	39	 	 	SPACE
fnp-6316	153	40	%	%	NOUN
fnp-6316	153	41	increments	increment	NOUN
fnp-6316	153	42	:	:	PUNCT
fnp-6316	153	43	pleomorphic	pleomorphic	ADJ
fnp-6316	153	44	,	,	PUNCT
fnp-6316	153	45	astrocytic	astrocytic	ADJ
fnp-6316	153	46	,	,	PUNCT
fnp-6316	153	47	gemistocytic	gemistocytic	ADJ
fnp-6316	153	48	,	,	PUNCT
fnp-6316	153	49	rhabdoid	rhabdoid	NOUN
fnp-6316	153	50	,	,	PUNCT
fnp-6316	153	51	oligodendroglioma	oligodendroglioma	VERB
fnp-6316	153	52	(	(	PUNCT
fnp-6316	153	53	odg)-like	odg)-like	VERB
fnp-6316	153	54	,	,	PUNCT
fnp-6316	153	55	small	small	ADJ
fnp-6316	153	56	,	,	PUNCT
fnp-6316	153	57	giant	giant	ADJ
fnp-6316	153	58	,	,	PUNCT
fnp-6316	153	59	spindle	spindle	NOUN
fnp-6316	153	60	,	,	PUNCT
fnp-6316	153	61	epithelioid	epithelioid	NOUN
fnp-6316	153	62	,	,	PUNCT
fnp-6316	153	63	primitive	primitive	ADJ
fnp-6316	153	64	neuronal	neuronal	ADJ
fnp-6316	153	65	differentiation(pnd)-like	differentiation(pnd)-like	NOUN
fnp-6316	153	66	and	and	CCONJ
fnp-6316	153	67	lipidized	lipidize	VERB
fnp-6316	153	68	[	[	PUNCT
fnp-6316	153	69	kirishima	kirishima	X
fnp-6316	153	70	et	et	PROPN
fnp-6316	153	71	al	al	PROPN
fnp-6316	153	72	.	.	PROPN
fnp-6316	153	73	,	,	PUNCT
fnp-6316	153	74	2024	2024	NUM
fnp-6316	153	75	;	;	PUNCT
fnp-6316	153	76	who	who	PRON
fnp-6316	153	77	classification	classification	NOUN
fnp-6316	153	78	of	of	ADP
fnp-6316	153	79	brain	brain	NOUN
fnp-6316	153	80	tumors	tumor	NOUN
fnp-6316	153	81	,	,	PUNCT
fnp-6316	153	82	2021	2021	NUM
fnp-6316	153	83	]	]	PUNCT
fnp-6316	153	84	.	.	PUNCT
fnp-6316	154	1	for	for	ADP
fnp-6316	154	2	histomorphological	histomorphological	ADJ
fnp-6316	154	3	assessment	assessment	NOUN
fnp-6316	154	4	to	to	PART
fnp-6316	154	5	construct	construct	VERB
fnp-6316	154	6	a	a	DET
fnp-6316	154	7	survival	survival	NOUN
fnp-6316	154	8	prediction	prediction	NOUN
fnp-6316	154	9	model	model	NOUN
fnp-6316	154	10	,	,	PUNCT
fnp-6316	154	11	the	the	DET
fnp-6316	154	12	largest	large	ADJ
fnp-6316	154	13	,	,	PUNCT
fnp-6316	154	14	most	most	ADV
fnp-6316	154	15	representative	representative	ADJ
fnp-6316	154	16	areas	area	NOUN
fnp-6316	154	17	were	be	AUX
fnp-6316	154	18	analyzed	analyze	VERB
fnp-6316	154	19	by	by	ADP
fnp-6316	154	20	two	two	NUM
fnp-6316	154	21	board	board	NOUN
fnp-6316	154	22	-	-	PUNCT
fnp-6316	154	23	certified	certify	VERB
fnp-6316	154	24	pathologists	pathologist	NOUN
fnp-6316	154	25	.	.	PUNCT
fnp-6316	155	1	of	of	ADP
fnp-6316	155	2	note	note	NOUN
fnp-6316	155	3	,	,	PUNCT
fnp-6316	155	4	also	also	ADV
fnp-6316	155	5	ngs	ng	VERB
fnp-6316	155	6	panel	panel	NOUN
fnp-6316	155	7	analysis	analysis	NOUN
fnp-6316	155	8	for	for	ADP
fnp-6316	155	9	genomic	genomic	ADJ
fnp-6316	155	10	profiling	profiling	NOUN
fnp-6316	155	11	,	,	PUNCT
fnp-6316	155	12	including	include	VERB
fnp-6316	155	13	assessment	assessment	NOUN
fnp-6316	155	14	of	of	ADP
fnp-6316	155	15	gene	gene	NOUN
fnp-6316	155	16	mutations	mutation	NOUN
fnp-6316	155	17	,	,	PUNCT
fnp-6316	155	18	copy	copy	VERB
fnp-6316	155	19	number	number	NOUN
fnp-6316	155	20	variation	variation	NOUN
fnp-6316	155	21	and	and	CCONJ
fnp-6316	155	22	1p/19q	1p/19q	NOUN
fnp-6316	155	23	co	co	NOUN
fnp-6316	155	24	-	-	NOUN
fnp-6316	155	25	deletion	deletion	NOUN
fnp-6316	155	26	as	as	ADV
fnp-6316	155	27	well	well	ADV
fnp-6316	155	28	as	as	ADP
fnp-6316	155	29	methylation	methylation	NOUN
fnp-6316	155	30	-	-	PUNCT
fnp-6316	155	31	specific	specific	ADJ
fnp-6316	155	32	pcr	pcr	NOUN
fnp-6316	155	33	to	to	PART
fnp-6316	155	34	determine	determine	VERB
fnp-6316	155	35	mgmt	mgmt	ADJ
fnp-6316	155	36	promoter	promoter	NOUN
fnp-6316	155	37	methylation	methylation	NOUN
fnp-6316	155	38	status	status	NOUN
fnp-6316	155	39	were	be	AUX
fnp-6316	155	40	performed	perform	VERB
fnp-6316	155	41	leading	lead	VERB
fnp-6316	155	42	to	to	ADP
fnp-6316	155	43	an	an	DET
fnp-6316	155	44	integrated	integrate	VERB
fnp-6316	155	45	final	final	ADJ
fnp-6316	155	46	diagnosis	diagnosis	NOUN
fnp-6316	155	47	together	together	ADV
fnp-6316	155	48	with	with	ADP
fnp-6316	155	49	histological	histological	ADJ
fnp-6316	155	50	and	and	CCONJ
fnp-6316	155	51	immunohistochemical	immunohistochemical	ADJ
fnp-6316	155	52	(	(	PUNCT
fnp-6316	155	53	e.g.	e.g.	ADV
fnp-6316	155	54	for	for	ADP
fnp-6316	155	55	idh1	idh1	PROPN
fnp-6316	155	56	-	-	PUNCT
fnp-6316	155	57	r132h	r132h	PROPN
fnp-6316	155	58	)	)	PUNCT
fnp-6316	155	59	features	feature	NOUN
fnp-6316	155	60	.	.	PUNCT
fnp-6316	156	1	as	as	SCONJ
fnp-6316	156	2	major	major	ADJ
fnp-6316	156	3	morphological	morphological	ADJ
fnp-6316	156	4	variants	variant	NOUN
fnp-6316	156	5	,	,	PUNCT
fnp-6316	156	6	pleomorphic	pleomorphic	ADJ
fnp-6316	156	7	(	(	PUNCT
fnp-6316	156	8	33	33	NUM
fnp-6316	156	9	 	 	SPACE
fnp-6316	156	10	%	%	NOUN
fnp-6316	156	11	of	of	ADP
fnp-6316	156	12	total	total	ADJ
fnp-6316	156	13	tumor	tumor	NOUN
fnp-6316	156	14	area	area	NOUN
fnp-6316	156	15	)	)	PUNCT
fnp-6316	156	16	and	and	CCONJ
fnp-6316	156	17	astrocytic	astrocytic	ADJ
fnp-6316	156	18	(	(	PUNCT
fnp-6316	156	19	29.1	29.1	NUM
fnp-6316	156	20	 	 	SPACE
fnp-6316	156	21	%	%	NOUN
fnp-6316	156	22	)	)	PUNCT
fnp-6316	156	23	differentiation	differentiation	NOUN
fnp-6316	156	24	were	be	AUX
fnp-6316	156	25	reported	report	VERB
fnp-6316	156	26	.	.	PUNCT
fnp-6316	157	1	most	most	ADV
fnp-6316	157	2	interestingly	interestingly	ADV
fnp-6316	157	3	,	,	PUNCT
fnp-6316	157	4	if	if	SCONJ
fnp-6316	157	5	glioblastoma	glioblastoma	NOUN
fnp-6316	157	6	showed	show	VERB
fnp-6316	157	7	epithelioid	epithelioid	NOUN
fnp-6316	157	8	tumor	tumor	NOUN
fnp-6316	157	9	cells	cell	NOUN
fnp-6316	157	10	in	in	ADP
fnp-6316	157	11	more	more	ADJ
fnp-6316	157	12	than	than	ADP
fnp-6316	157	13	30	30	NUM
fnp-6316	157	14	 	 	SPACE
fnp-6316	157	15	%	%	NOUN
fnp-6316	157	16	of	of	ADP
fnp-6316	157	17	total	total	ADJ
fnp-6316	157	18	tumor	tumor	NOUN
fnp-6316	157	19	cells	cell	NOUN
fnp-6316	157	20	,	,	PUNCT
fnp-6316	157	21	patients	patient	NOUN
fnp-6316	157	22	displayed	display	VERB
fnp-6316	157	23	an	an	DET
fnp-6316	157	24	unfavorable	unfavorable	ADJ
fnp-6316	157	25	prognosis	prognosis	NOUN
fnp-6316	157	26	independent	independent	NOUN
fnp-6316	157	27	of	of	ADP
fnp-6316	157	28	clinical	clinical	ADJ
fnp-6316	157	29	parameters	parameter	NOUN
fnp-6316	157	30	,	,	PUNCT
fnp-6316	157	31	treatment	treatment	NOUN
fnp-6316	157	32	or	or	CCONJ
fnp-6316	157	33	molecular	molecular	ADJ
fnp-6316	157	34	alterations	alteration	NOUN
fnp-6316	157	35	.	.	PUNCT
fnp-6316	158	1	the	the	DET
fnp-6316	158	2	most	most	ADV
fnp-6316	158	3	favorable	favorable	ADJ
fnp-6316	158	4	prognostic	prognostic	ADJ
fnp-6316	158	5	values	value	NOUN
fnp-6316	158	6	for	for	ADP
fnp-6316	158	7	glioblastoma	glioblastoma	NOUN
fnp-6316	158	8	patients	patient	NOUN
fnp-6316	158	9	could	could	AUX
fnp-6316	158	10	be	be	AUX
fnp-6316	158	11	achieved	achieve	VERB
fnp-6316	158	12	by	by	ADP
fnp-6316	158	13	calculating	calculate	VERB
fnp-6316	158	14	a	a	DET
fnp-6316	158	15	combined	combine	VERB
fnp-6316	158	16	score	score	NOUN
fnp-6316	158	17	taking	take	VERB
fnp-6316	158	18	into	into	ADP
fnp-6316	158	19	account	account	NOUN
fnp-6316	158	20	both	both	CCONJ
fnp-6316	158	21	gemistocytic	gemistocytic	ADJ
fnp-6316	158	22	and	and	CCONJ
fnp-6316	158	23	epithelioid	epithelioid	NOUN
fnp-6316	158	24	areas	area	NOUN
fnp-6316	158	25	as	as	SCONJ
fnp-6316	158	26	follows	follow	VERB
fnp-6316	158	27	:	:	PUNCT
fnp-6316	158	28	%	%	NOUN
fnp-6316	158	29	area	area	NOUN
fnp-6316	158	30	of	of	ADP
fnp-6316	158	31	gemistocytic	gemistocytic	ADJ
fnp-6316	158	32	cells	cell	NOUN
fnp-6316	158	33	minus	minus	CCONJ
fnp-6316	158	34	4	4	NUM
fnp-6316	158	35	x	x	NOUN
fnp-6316	158	36	%	%	NOUN
fnp-6316	158	37	area	area	NOUN
fnp-6316	158	38	of	of	ADP
fnp-6316	158	39	epithelioid	epithelioid	NOUN
fnp-6316	158	40	cells	cell	NOUN
fnp-6316	158	41	.	.	PUNCT
fnp-6316	159	1	a	a	DET
fnp-6316	159	2	value	value	NOUN
fnp-6316	159	3	of	of	ADP
fnp-6316	159	4	less	less	ADJ
fnp-6316	159	5	than	than	ADP
fnp-6316	159	6	20	20	NUM
fnp-6316	159	7	 	 	SPACE
fnp-6316	159	8	%	%	NOUN
fnp-6316	159	9	of	of	ADP
fnp-6316	159	10	this	this	DET
fnp-6316	159	11	index	index	NOUN
fnp-6316	159	12	was	be	AUX
fnp-6316	159	13	an	an	DET
fnp-6316	159	14	independent	independent	ADJ
fnp-6316	159	15	significant	significant	ADJ
fnp-6316	159	16	factor	factor	NOUN
fnp-6316	159	17	for	for	ADP
fnp-6316	159	18	worse	bad	ADJ
fnp-6316	159	19	survival	survival	NOUN
fnp-6316	159	20	in	in	ADP
fnp-6316	159	21	a	a	DET
fnp-6316	159	22	multivariate	multivariate	NOUN
fnp-6316	159	23	analyses	analyse	VERB
fnp-6316	159	24	together	together	ADV
fnp-6316	159	25	with	with	ADP
fnp-6316	159	26	age	age	NOUN
fnp-6316	159	27	,	,	PUNCT
fnp-6316	159	28	medullary	medullary	ADJ
fnp-6316	159	29	dissemination	dissemination	NOUN
fnp-6316	159	30	,	,	PUNCT
fnp-6316	159	31	chemotherapy	chemotherapy	NOUN
fnp-6316	159	32	and	and	CCONJ
fnp-6316	159	33	mgmt	mgmt	PROPN
fnp-6316	159	34	promoter	promoter	NOUN
fnp-6316	159	35	methylation	methylation	NOUN
fnp-6316	159	36	status	status	NOUN
fnp-6316	159	37	(	(	PUNCT
fnp-6316	159	38	for	for	ADP
fnp-6316	159	39	summary	summary	NOUN
fnp-6316	159	40	see	see	VERB
fnp-6316	159	41	figure	figure	NOUN
fnp-6316	159	42	 	 	SPACE
fnp-6316	159	43	6	6	NUM
fnp-6316	159	44	)	)	PUNCT
fnp-6316	159	45	.	.	PUNCT
fnp-6316	160	1	the	the	DET
fnp-6316	160	2	prediction	prediction	NOUN
fnp-6316	160	3	for	for	ADP
fnp-6316	160	4	patient	patient	ADJ
fnp-6316	160	5	survival	survival	NOUN
fnp-6316	160	6	could	could	AUX
fnp-6316	160	7	be	be	AUX
fnp-6316	160	8	further	far	ADV
fnp-6316	160	9	increased	increase	VERB
fnp-6316	160	10	by	by	ADP
fnp-6316	160	11	combining	combine	VERB
fnp-6316	160	12	this	this	DET
fnp-6316	160	13	index	index	NOUN
fnp-6316	160	14	with	with	ADP
fnp-6316	160	15	the	the	DET
fnp-6316	160	16	mgmt	mgmt	PROPN
fnp-6316	160	17	promoter	promoter	NOUN
fnp-6316	160	18	methylation	methylation	NOUN
fnp-6316	160	19	status	status	NOUN
fnp-6316	160	20	,	,	PUNCT
fnp-6316	160	21	showing	show	VERB
fnp-6316	160	22	worst	bad	ADJ
fnp-6316	160	23	patient	patient	ADJ
fnp-6316	160	24	survival	survival	NOUN
fnp-6316	160	25	for	for	ADP
fnp-6316	160	26	the	the	DET
fnp-6316	160	27	combination	combination	NOUN
fnp-6316	160	28	of	of	ADP
fnp-6316	160	29	a	a	DET
fnp-6316	160	30	low	low	ADJ
fnp-6316	160	31	index	index	NOUN
fnp-6316	160	32	together	together	ADV
fnp-6316	160	33	with	with	ADP
fnp-6316	160	34	an	an	DET
fnp-6316	160	35	unmethylated	unmethylated	ADJ
fnp-6316	160	36	mgmt	mgmt	NOUN
fnp-6316	160	37	promoter	promoter	NOUN
fnp-6316	160	38	.	.	PUNCT
fnp-6316	161	1	as	as	SCONJ
fnp-6316	161	2	only	only	ADV
fnp-6316	161	3	6	6	NUM
fnp-6316	161	4	out	out	ADP
fnp-6316	161	5	of	of	ADP
fnp-6316	161	6	227	227	NUM
fnp-6316	161	7	displayed	display	VERB
fnp-6316	161	8	an	an	DET
fnp-6316	161	9	epithelioid	epithelioid	NOUN
fnp-6316	161	10	phenotype	phenotype	NOUN
fnp-6316	161	11	,	,	PUNCT
fnp-6316	161	12	the	the	DET
fnp-6316	161	13	results	result	NOUN
fnp-6316	161	14	certainly	certainly	ADV
fnp-6316	161	15	have	have	VERB
fnp-6316	161	16	to	to	PART
fnp-6316	161	17	be	be	AUX
fnp-6316	161	18	considered	consider	VERB
fnp-6316	161	19	with	with	ADP
fnp-6316	161	20	caution	caution	NOUN
fnp-6316	161	21	,	,	PUNCT
fnp-6316	161	22	nevertheless	nevertheless	ADV
fnp-6316	161	23	,	,	PUNCT
fnp-6316	161	24	the	the	DET
fnp-6316	161	25	prognostic	prognostic	ADJ
fnp-6316	161	26	impact	impact	NOUN
fnp-6316	161	27	of	of	ADP
fnp-6316	161	28	such	such	DET
fnp-6316	161	29	a	a	DET
fnp-6316	161	30	differentiation	differentiation	NOUN
fnp-6316	161	31	seemed	seem	VERB
fnp-6316	161	32	to	to	PART
fnp-6316	161	33	be	be	AUX
fnp-6316	161	34	strongly	strongly	ADV
fnp-6316	161	35	associated	associate	VERB
fnp-6316	161	36	with	with	ADP
fnp-6316	161	37	negative	negative	ADJ
fnp-6316	161	38	patient	patient	ADJ
fnp-6316	161	39	survival	survival	NOUN
fnp-6316	161	40	even	even	ADV
fnp-6316	161	41	in	in	ADP
fnp-6316	161	42	a	a	DET
fnp-6316	161	43	multivariate	multivariate	NOUN
fnp-6316	161	44	analysis	analysis	NOUN
fnp-6316	161	45	.	.	PUNCT
fnp-6316	162	1	although	although	SCONJ
fnp-6316	162	2	a	a	DET
fnp-6316	162	3	detailed	detailed	ADJ
fnp-6316	162	4	definition	definition	NOUN
fnp-6316	162	5	of	of	ADP
fnp-6316	162	6	cell	cell	NOUN
fnp-6316	162	7	morphology	morphology	NOUN
fnp-6316	162	8	is	be	AUX
fnp-6316	162	9	provided	provide	VERB
fnp-6316	162	10	by	by	ADP
fnp-6316	162	11	the	the	DET
fnp-6316	162	12	authors	author	NOUN
fnp-6316	162	13	,	,	PUNCT
fnp-6316	162	14	the	the	DET
fnp-6316	162	15	reproducibility	reproducibility	NOUN
fnp-6316	162	16	of	of	ADP
fnp-6316	162	17	such	such	DET
fnp-6316	162	18	an	an	DET
fnp-6316	162	19	analysis	analysis	NOUN
fnp-6316	162	20	with	with	ADP
fnp-6316	162	21	still	still	ADV
fnp-6316	162	22	suffer	suffer	VERB
fnp-6316	162	23	from	from	ADP
fnp-6316	162	24	the	the	DET
fnp-6316	162	25	subjective	subjective	ADJ
fnp-6316	162	26	interpretation	interpretation	NOUN
fnp-6316	162	27	of	of	ADP
fnp-6316	162	28	individual	individual	ADJ
fnp-6316	162	29	neuropathologist	neuropathologist	NOUN
fnp-6316	162	30	.	.	PUNCT
fnp-6316	163	1	if	if	SCONJ
fnp-6316	163	2	this	this	DET
fnp-6316	163	3	approach	approach	NOUN
fnp-6316	163	4	should	should	AUX
fnp-6316	163	5	enter	enter	VERB
fnp-6316	163	6	the	the	DET
fnp-6316	163	7	diagnostic	diagnostic	ADJ
fnp-6316	163	8	routine	routine	NOUN
fnp-6316	163	9	,	,	PUNCT
fnp-6316	163	10	future	future	ADJ
fnp-6316	163	11	automated	automate	VERB
fnp-6316	163	12	digital	digital	ADJ
fnp-6316	163	13	image	image	NOUN
fnp-6316	163	14	analysis	analysis	NOUN
fnp-6316	163	15	would	would	AUX
fnp-6316	163	16	be	be	AUX
fnp-6316	163	17	preferable	preferable	ADJ
fnp-6316	163	18	to	to	PART
fnp-6316	163	19	undoubtfully	undoubtfully	ADV
fnp-6316	163	20	recognize	recognize	VERB
fnp-6316	163	21	and	and	CCONJ
fnp-6316	163	22	grade	grade	VERB
fnp-6316	163	23	the	the	DET
fnp-6316	163	24	morphological	morphological	ADJ
fnp-6316	163	25	parameters	parameter	NOUN
fnp-6316	163	26	7	7	NUM
fnp-6316	163	27	.	.	PUNCT
fnp-6316	164	1	confocal	confocal	ADJ
fnp-6316	164	2	laser	laser	NOUN
fnp-6316	164	3	microscopy	microscopy	NOUN
fnp-6316	164	4	for	for	ADP
fnp-6316	164	5	intraoperative	intraoperative	ADJ
fnp-6316	164	6	histopathological	histopathological	ADJ
fnp-6316	164	7	diagnostics	diagnostic	NOUN
fnp-6316	164	8	of	of	ADP
fnp-6316	164	9	intracranial	intracranial	ADJ
fnp-6316	164	10	tumors	tumor	NOUN
fnp-6316	165	1	[	[	X
fnp-6316	165	2	wagner	wagner	X
fnp-6316	165	3	et	et	PROPN
fnp-6316	165	4	al	al	PROPN
fnp-6316	165	5	.	.	PROPN
fnp-6316	165	6	,	,	PUNCT
fnp-6316	165	7	2024	2024	NUM
fnp-6316	165	8	]	]	PUNCT
fnp-6316	165	9	intraoperative	intraoperative	ADJ
fnp-6316	165	10	diagnostics	diagnostic	NOUN
fnp-6316	165	11	performed	perform	VERB
fnp-6316	165	12	on	on	ADP
fnp-6316	165	13	frozen	frozen	ADJ
fnp-6316	165	14	sections	section	NOUN
fnp-6316	165	15	is	be	AUX
fnp-6316	165	16	time	time	NOUN
fnp-6316	165	17	-	-	PUNCT
fnp-6316	165	18	consuming	consume	VERB
fnp-6316	165	19	,	,	PUNCT
fnp-6316	165	20	often	often	ADV
fnp-6316	165	21	lasting	last	VERB
fnp-6316	165	22	around	around	ADP
fnp-6316	165	23	20	20	NUM
fnp-6316	165	24	minutes	minute	NOUN
fnp-6316	165	25	from	from	ADP
fnp-6316	165	26	tissue	tissue	NOUN
fnp-6316	165	27	sampling	sample	VERB
fnp-6316	165	28	out	out	ADP
fnp-6316	165	29	of	of	ADP
fnp-6316	165	30	the	the	DET
fnp-6316	165	31	surgical	surgical	ADJ
fnp-6316	165	32	cavity	cavity	NOUN
fnp-6316	165	33	to	to	ADP
fnp-6316	165	34	the	the	DET
fnp-6316	165	35	final	final	ADJ
fnp-6316	165	36	transmission	transmission	NOUN
fnp-6316	165	37	of	of	ADP
fnp-6316	165	38	the	the	DET
fnp-6316	165	39	diagnosis	diagnosis	NOUN
fnp-6316	165	40	[	[	X
fnp-6316	165	41	novis	novis	NOUN
fnp-6316	165	42	and	and	CCONJ
fnp-6316	165	43	zarbo	zarbo	NOUN
fnp-6316	165	44	,	,	PUNCT
fnp-6316	165	45	1997	1997	NUM
fnp-6316	165	46	]	]	PUNCT
fnp-6316	165	47	.	.	PUNCT
fnp-6316	166	1	in	in	ADP
fnp-6316	166	2	addition	addition	NOUN
fnp-6316	166	3	,	,	PUNCT
fnp-6316	166	4	only	only	ADV
fnp-6316	166	5	single	single	ADJ
fnp-6316	166	6	,	,	PUNCT
fnp-6316	166	7	mostly	mostly	ADV
fnp-6316	166	8	very	very	ADV
fnp-6316	166	9	small	small	ADJ
fnp-6316	166	10	tissue	tissue	NOUN
fnp-6316	166	11	fragments	fragment	NOUN
fnp-6316	166	12	can	can	AUX
fnp-6316	166	13	be	be	AUX
fnp-6316	166	14	assessed	assess	VERB
fnp-6316	166	15	at	at	ADP
fnp-6316	166	16	a	a	DET
fnp-6316	166	17	time	time	NOUN
fnp-6316	166	18	.	.	PUNCT
fnp-6316	167	1	even	even	ADV
fnp-6316	167	2	in	in	ADP
fnp-6316	167	3	highly	highly	ADV
fnp-6316	167	4	specialized	specialized	ADJ
fnp-6316	167	5	tertiary	tertiary	ADJ
fnp-6316	167	6	medical	medical	ADJ
fnp-6316	167	7	centers	center	NOUN
fnp-6316	167	8	,	,	PUNCT
fnp-6316	167	9	a	a	DET
fnp-6316	167	10	diagnostic	diagnostic	ADJ
fnp-6316	167	11	shift	shift	NOUN
fnp-6316	167	12	of	of	ADP
fnp-6316	167	13	18	18	NUM
fnp-6316	167	14	 	 	SPACE
fnp-6316	167	15	%	%	NOUN
fnp-6316	167	16	between	between	ADP
fnp-6316	167	17	intraoperative	intraoperative	ADJ
fnp-6316	167	18	and	and	CCONJ
fnp-6316	167	19	post	post	ADJ
fnp-6316	167	20	-	-	ADJ
fnp-6316	167	21	operative	operative	ADJ
fnp-6316	167	22	diagnoses	diagnosis	NOUN
fnp-6316	167	23	was	be	AUX
fnp-6316	167	24	reported	report	VERB
fnp-6316	167	25	,	,	PUNCT
fnp-6316	167	26	actually	actually	ADV
fnp-6316	167	27	leading	lead	VERB
fnp-6316	167	28	to	to	ADP
fnp-6316	167	29	a	a	DET
fnp-6316	167	30	second	second	ADJ
fnp-6316	167	31	subsequent	subsequent	ADJ
fnp-6316	167	32	neurosurgical	neurosurgical	ADJ
fnp-6316	167	33	intervention	intervention	NOUN
fnp-6316	167	34	in	in	ADP
fnp-6316	167	35	3	3	NUM
fnp-6316	167	36	 	 	SPACE
fnp-6316	167	37	%	%	NOUN
fnp-6316	167	38	of	of	ADP
fnp-6316	167	39	all	all	DET
fnp-6316	167	40	brain	brain	NOUN
fnp-6316	167	41	tumor	tumor	NOUN
fnp-6316	167	42	patients	patient	NOUN
fnp-6316	167	43	[	[	PUNCT
fnp-6316	167	44	harms	harm	VERB
fnp-6316	167	45	et	et	NOUN
fnp-6316	167	46	al	al	PROPN
fnp-6316	167	47	.	.	PROPN
fnp-6316	167	48	,	,	PUNCT
fnp-6316	167	49	2023	2023	NUM
fnp-6316	167	50	]	]	PUNCT
fnp-6316	167	51	.	.	PUNCT
fnp-6316	168	1	therefore	therefore	ADV
fnp-6316	168	2	,	,	PUNCT
fnp-6316	168	3	there	there	PRON
fnp-6316	168	4	is	be	VERB
fnp-6316	168	5	an	an	DET
fnp-6316	168	6	urgent	urgent	ADJ
fnp-6316	168	7	need	need	NOUN
fnp-6316	168	8	for	for	ADP
fnp-6316	168	9	faster	fast	ADJ
fnp-6316	168	10	methods	method	NOUN
fnp-6316	168	11	that	that	PRON
fnp-6316	168	12	can	can	AUX
fnp-6316	168	13	also	also	ADV
fnp-6316	168	14	repeatedly	repeatedly	ADV
fnp-6316	168	15	analyze	analyze	VERB
fnp-6316	168	16	larger	large	ADJ
fnp-6316	168	17	tissue	tissue	NOUN
fnp-6316	168	18	areas	area	NOUN
fnp-6316	168	19	,	,	PUNCT
fnp-6316	168	20	ideally	ideally	ADV
fnp-6316	168	21	in	in	ADP
fnp-6316	168	22	real	real	ADJ
fnp-6316	168	23	-	-	PUNCT
fnp-6316	168	24	time	time	NOUN
fnp-6316	168	25	and/or	and/or	CCONJ
fnp-6316	168	26	directly	directly	ADV
fnp-6316	168	27	in	in	ADP
fnp-6316	168	28	situ	situ	NOUN
fnp-6316	168	29	.	.	PUNCT
fnp-6316	169	1	to	to	PART
fnp-6316	169	2	address	address	VERB
fnp-6316	169	3	this	this	DET
fnp-6316	169	4	issue	issue	NOUN
fnp-6316	169	5	,	,	PUNCT
fnp-6316	169	6	wagner	wagner	PROPN
fnp-6316	169	7	et	et	PROPN
fnp-6316	169	8	al	al	PROPN
fnp-6316	169	9	.	.	PROPN
fnp-6316	169	10	conducted	conduct	VERB
fnp-6316	169	11	a	a	DET
fnp-6316	169	12	phase	phase	NOUN
fnp-6316	169	13	ii	ii	NOUN
fnp-6316	169	14	clinical	clinical	ADJ
fnp-6316	169	15	study	study	NOUN
fnp-6316	169	16	to	to	PART
fnp-6316	169	17	test	test	VERB
fnp-6316	169	18	the	the	DET
fnp-6316	169	19	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	169	20	free	free	ADJ
fnp-6316	169	21	neuropathology	neuropathology	NOUN
fnp-6316	169	22	6:10	6:10	NUM
fnp-6316	169	23	(	(	PUNCT
fnp-6316	169	24	2025	2025	NUM
fnp-6316	169	25	)	)	PUNCT
fnp-6316	169	26	michel	michel	PROPN
fnp-6316	169	27	mittelbronn	mittelbronn	PROPN
fnp-6316	169	28	doi	doi	PROPN
fnp-6316	169	29	:	:	PUNCT
fnp-6316	169	30	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	169	31	page	page	NOUN
fnp-6316	169	32	11	11	NUM
fnp-6316	169	33	of	of	ADP
fnp-6316	169	34	19	19	NUM
fnp-6316	169	35	figure	figure	NOUN
fnp-6316	169	36	 	 	SPACE
fnp-6316	169	37	6	6	NUM
fnp-6316	169	38	:	:	PUNCT
fnp-6316	169	39	prognostic	prognostic	ADJ
fnp-6316	169	40	prediction	prediction	NOUN
fnp-6316	169	41	of	of	ADP
fnp-6316	169	42	histological	histological	ADJ
fnp-6316	169	43	features	feature	NOUN
fnp-6316	169	44	in	in	ADP
fnp-6316	169	45	glioblastoma	glioblastoma	NOUN
fnp-6316	169	46	noninferiority	noninferiority	NOUN
fnp-6316	169	47	of	of	ADP
fnp-6316	169	48	fluorescein	fluorescein	NOUN
fnp-6316	169	49	-	-	PUNCT
fnp-6316	169	50	stained	stain	VERB
fnp-6316	169	51	intraoperative	intraoperative	ADJ
fnp-6316	169	52	confocal	confocal	ADJ
fnp-6316	169	53	laser	laser	NOUN
fnp-6316	169	54	endomicroscopy	endomicroscopy	VERB
fnp-6316	169	55	(	(	PUNCT
fnp-6316	169	56	cle	cle	NOUN
fnp-6316	169	57	)	)	PUNCT
fnp-6316	169	58	compared	compare	VERB
fnp-6316	169	59	to	to	ADP
fnp-6316	169	60	the	the	DET
fnp-6316	169	61	classic	classic	ADJ
fnp-6316	169	62	assessment	assessment	NOUN
fnp-6316	169	63	of	of	ADP
fnp-6316	169	64	frozen	frozen	ADJ
fnp-6316	169	65	sections	section	NOUN
fnp-6316	169	66	by	by	ADP
fnp-6316	169	67	neuropathologists	neuropathologist	NOUN
fnp-6316	169	68	in	in	ADP
fnp-6316	169	69	210	210	NUM
fnp-6316	169	70	adult	adult	NOUN
fnp-6316	169	71	brain	brain	NOUN
fnp-6316	169	72	tumor	tumor	NOUN
fnp-6316	169	73	patients	patient	NOUN
fnp-6316	169	74	.	.	PUNCT
fnp-6316	170	1	cle	cle	NOUN
fnp-6316	170	2	(	(	PUNCT
fnp-6316	170	3	using	use	VERB
fnp-6316	170	4	the	the	DET
fnp-6316	170	5	zeiss	zeiss	PROPN
fnp-6316	170	6	convivo	convivo	PROPN
fnp-6316	170	7	system	system	NOUN
fnp-6316	170	8	)	)	PUNCT
fnp-6316	170	9	is	be	AUX
fnp-6316	170	10	a	a	DET
fnp-6316	170	11	non	non	ADJ
fnp-6316	170	12	-	-	ADJ
fnp-6316	170	13	invasive	invasive	ADJ
fnp-6316	170	14	/	/	SYM
fnp-6316	170	15	non	non	ADJ
fnp-6316	170	16	-	-	ADJ
fnp-6316	170	17	traumatic	traumatic	ADJ
fnp-6316	170	18	technique	technique	NOUN
fnp-6316	170	19	that	that	PRON
fnp-6316	170	20	enables	enable	VERB
fnp-6316	170	21	histopathological	histopathological	ADJ
fnp-6316	170	22	assessment	assessment	NOUN
fnp-6316	170	23	in	in	ADP
fnp-6316	170	24	vivo	vivo	NOUN
fnp-6316	170	25	almost	almost	ADV
fnp-6316	170	26	in	in	ADP
fnp-6316	170	27	real	real	ADJ
fnp-6316	170	28	time	time	NOUN
fnp-6316	170	29	.	.	PUNCT
fnp-6316	171	1	in	in	ADP
fnp-6316	171	2	addition	addition	NOUN
fnp-6316	171	3	,	,	PUNCT
fnp-6316	171	4	fluorescein	fluorescein	ADJ
fnp-6316	171	5	sodium	sodium	NOUN
fnp-6316	171	6	acts	act	VERB
fnp-6316	171	7	as	as	ADP
fnp-6316	171	8	a	a	DET
fnp-6316	171	9	contrast	contrast	NOUN
fnp-6316	171	10	-	-	PUNCT
fnp-6316	171	11	enhancing	enhance	VERB
fnp-6316	171	12	intraoperative	intraoperative	ADJ
fnp-6316	171	13	dye	dye	NOUN
fnp-6316	171	14	for	for	ADP
fnp-6316	171	15	an	an	DET
fnp-6316	171	16	easier	easy	ADJ
fnp-6316	171	17	identification	identification	NOUN
fnp-6316	171	18	of	of	ADP
fnp-6316	171	19	the	the	DET
fnp-6316	171	20	tumor	tumor	NOUN
fnp-6316	171	21	-	-	PUNCT
fnp-6316	171	22	suspicious	suspicious	ADJ
fnp-6316	171	23	areas	area	NOUN
fnp-6316	171	24	.	.	PUNCT
fnp-6316	172	1	of	of	ADP
fnp-6316	172	2	note	note	NOUN
fnp-6316	172	3	,	,	PUNCT
fnp-6316	172	4	no	no	DET
fnp-6316	172	5	serious	serious	ADJ
fnp-6316	172	6	adverse	adverse	ADJ
fnp-6316	172	7	events	event	NOUN
fnp-6316	172	8	were	be	AUX
fnp-6316	172	9	reported	report	VERB
fnp-6316	172	10	,	,	PUNCT
fnp-6316	172	11	neither	neither	CCONJ
fnp-6316	172	12	in	in	ADP
fnp-6316	172	13	relation	relation	NOUN
fnp-6316	172	14	to	to	PART
fnp-6316	172	15	cle	cle	VERB
fnp-6316	172	16	nor	nor	CCONJ
fnp-6316	172	17	to	to	ADP
fnp-6316	172	18	fluorescein	fluorescein	NOUN
fnp-6316	172	19	.	.	PUNCT
fnp-6316	173	1	compared	compare	VERB
fnp-6316	173	2	to	to	ADP
fnp-6316	173	3	the	the	DET
fnp-6316	173	4	final	final	ADJ
fnp-6316	173	5	neuropathological	neuropathological	ADJ
fnp-6316	173	6	diagnoses	diagnosis	NOUN
fnp-6316	173	7	,	,	PUNCT
fnp-6316	173	8	a	a	DET
fnp-6316	173	9	correct	correct	ADJ
fnp-6316	173	10	result	result	NOUN
fnp-6316	173	11	was	be	AUX
fnp-6316	173	12	obtained	obtain	VERB
fnp-6316	173	13	in	in	ADP
fnp-6316	173	14	87	87	NUM
fnp-6316	173	15	 	 	SPACE
fnp-6316	173	16	%	%	NOUN
fnp-6316	173	17	of	of	ADP
fnp-6316	173	18	cle	cle	ADJ
fnp-6316	173	19	-	-	ADJ
fnp-6316	173	20	assessed	assess	VERB
fnp-6316	173	21	samples	sample	NOUN
fnp-6316	173	22	,	,	PUNCT
fnp-6316	173	23	while	while	SCONJ
fnp-6316	173	24	classic	classic	ADJ
fnp-6316	173	25	frozen	frozen	ADJ
fnp-6316	173	26	sections	section	NOUN
fnp-6316	173	27	achieved	achieve	VERB
fnp-6316	173	28	91	91	NUM
fnp-6316	173	29	 	 	SPACE
fnp-6316	173	30	%	%	NOUN
fnp-6316	173	31	,	,	PUNCT
fnp-6316	173	32	demonstrating	demonstrate	VERB
fnp-6316	173	33	the	the	DET
fnp-6316	173	34	noninferiority	noninferiority	NOUN
fnp-6316	173	35	of	of	ADP
fnp-6316	173	36	the	the	DET
fnp-6316	173	37	cle	cle	NOUN
fnp-6316	173	38	method	method	NOUN
fnp-6316	173	39	(	(	PUNCT
fnp-6316	173	40	figure	figure	NOUN
fnp-6316	173	41	 	 	SPACE
fnp-6316	173	42	7	7	NUM
fnp-6316	173	43	)	)	PUNCT
fnp-6316	173	44	.	.	PUNCT
fnp-6316	174	1	the	the	DET
fnp-6316	174	2	concordance	concordance	NOUN
fnp-6316	174	3	rate	rate	NOUN
fnp-6316	174	4	between	between	ADP
fnp-6316	174	5	cle	cle	NOUN
fnp-6316	174	6	and	and	CCONJ
fnp-6316	174	7	classic	classic	ADJ
fnp-6316	174	8	frozen	frozen	ADJ
fnp-6316	174	9	sections	section	NOUN
fnp-6316	174	10	was	be	AUX
fnp-6316	174	11	76	76	NUM
fnp-6316	174	12	 	 	SPACE
fnp-6316	174	13	%	%	NOUN
fnp-6316	174	14	.	.	PUNCT
fnp-6316	175	1	most	most	ADV
fnp-6316	175	2	importantly	importantly	ADV
fnp-6316	175	3	,	,	PUNCT
fnp-6316	175	4	the	the	DET
fnp-6316	175	5	median	median	ADJ
fnp-6316	175	6	time	time	NOUN
fnp-6316	175	7	until	until	SCONJ
fnp-6316	175	8	cle	cle	NOUN
fnp-6316	175	9	diagnosis	diagnosis	NOUN
fnp-6316	175	10	was	be	AUX
fnp-6316	175	11	communicated	communicate	VERB
fnp-6316	175	12	was	be	AUX
fnp-6316	175	13	3	3	NUM
fnp-6316	175	14	min	min	NOUN
fnp-6316	175	15	compared	compare	VERB
fnp-6316	175	16	to	to	ADP
fnp-6316	175	17	27	27	NUM
fnp-6316	175	18	min	min	NOUN
fnp-6316	175	19	in	in	ADP
fnp-6316	175	20	classic	classic	ADJ
fnp-6316	175	21	frozen	frozen	ADJ
fnp-6316	175	22	sections	section	NOUN
fnp-6316	175	23	,	,	PUNCT
fnp-6316	175	24	resulting	result	VERB
fnp-6316	175	25	in	in	ADP
fnp-6316	175	26	a	a	DET
fnp-6316	175	27	nearly	nearly	ADV
fnp-6316	175	28	10	10	NUM
fnp-6316	175	29	-	-	ADJ
fnp-6316	175	30	fold	fold	ADJ
fnp-6316	175	31	reduction	reduction	NOUN
fnp-6316	175	32	of	of	ADP
fnp-6316	175	33	time	time	NOUN
fnp-6316	175	34	required	require	VERB
fnp-6316	175	35	for	for	ADP
fnp-6316	175	36	intraoperative	intraoperative	ADJ
fnp-6316	175	37	neuropathological	neuropathological	ADJ
fnp-6316	175	38	assessment	assessment	NOUN
fnp-6316	175	39	.	.	PUNCT
fnp-6316	176	1	in	in	ADP
fnp-6316	176	2	summary	summary	NOUN
fnp-6316	176	3	,	,	PUNCT
fnp-6316	176	4	in	in	ADP
fnp-6316	176	5	vivo	vivo	NOUN
fnp-6316	176	6	cle	cle	NOUN
fnp-6316	176	7	assessment	assessment	NOUN
fnp-6316	176	8	for	for	ADP
fnp-6316	176	9	intraoperative	intraoperative	ADJ
fnp-6316	176	10	neuropathological	neuropathological	ADJ
fnp-6316	176	11	diagnostics	diagnostic	NOUN
fnp-6316	176	12	is	be	AUX
fnp-6316	176	13	a	a	DET
fnp-6316	176	14	highly	highly	ADV
fnp-6316	176	15	reliable	reliable	ADJ
fnp-6316	176	16	and	and	CCONJ
fnp-6316	176	17	significantly	significantly	ADV
fnp-6316	176	18	faster	fast	ADV
fnp-6316	176	19	approach	approach	NOUN
fnp-6316	176	20	that	that	PRON
fnp-6316	176	21	could	could	AUX
fnp-6316	176	22	at	at	ADV
fnp-6316	176	23	least	least	ADV
fnp-6316	176	24	partially	partially	ADV
fnp-6316	176	25	replace	replace	VERB
fnp-6316	176	26	frozen	frozen	ADJ
fnp-6316	176	27	section	section	NOUN
fnp-6316	176	28	diagnostics	diagnostic	NOUN
fnp-6316	176	29	in	in	ADP
fnp-6316	176	30	the	the	DET
fnp-6316	176	31	future	future	NOUN
fnp-6316	176	32	.	.	PUNCT
fnp-6316	177	1	in	in	ADP
fnp-6316	177	2	addition	addition	NOUN
fnp-6316	177	3	,	,	PUNCT
fnp-6316	177	4	a	a	DET
fnp-6316	177	5	considerably	considerably	ADV
fnp-6316	177	6	higher	high	ADJ
fnp-6316	177	7	amount	amount	NOUN
fnp-6316	177	8	of	of	ADP
fnp-6316	177	9	tissue	tissue	NOUN
fnp-6316	177	10	images	image	NOUN
fnp-6316	177	11	could	could	AUX
fnp-6316	177	12	be	be	AUX
fnp-6316	177	13	processed	process	VERB
fnp-6316	177	14	thereby	thereby	ADV
fnp-6316	177	15	further	far	ADV
fnp-6316	177	16	increasing	increase	VERB
fnp-6316	177	17	its	its	PRON
fnp-6316	177	18	diagnostic	diagnostic	ADJ
fnp-6316	177	19	validity	validity	NOUN
fnp-6316	177	20	.	.	PUNCT
fnp-6316	178	1	8	8	X
fnp-6316	178	2	.	.	X
fnp-6316	178	3	brain	brain	NOUN
fnp-6316	178	4	tumor	tumor	NOUN
fnp-6316	178	5	diagnostics	diagnostic	NOUN
fnp-6316	178	6	from	from	ADP
fnp-6316	178	7	cellfree	cellfree	ADJ
fnp-6316	178	8	dna	dna	NOUN
fnp-6316	178	9	from	from	ADP
fnp-6316	178	10	cerebrospinal	cerebrospinal	ADJ
fnp-6316	178	11	fluid	fluid	NOUN
fnp-6316	178	12	[	[	X
fnp-6316	178	13	afflerbach	afflerbach	NOUN
fnp-6316	178	14	et	et	PROPN
fnp-6316	178	15	al	al	PROPN
fnp-6316	178	16	.	.	PROPN
fnp-6316	178	17	,	,	PUNCT
fnp-6316	178	18	2024	2024	NUM
fnp-6316	178	19	and	and	CCONJ
fnp-6316	178	20	hickman	hickman	PROPN
fnp-6316	178	21	et	et	PROPN
fnp-6316	178	22	al	al	PROPN
fnp-6316	178	23	.	.	PROPN
fnp-6316	178	24	,	,	PUNCT
fnp-6316	178	25	2024	2024	NUM
fnp-6316	178	26	]	]	PUNCT
fnp-6316	178	27	precise	precise	ADJ
fnp-6316	178	28	brain	brain	NOUN
fnp-6316	178	29	tumor	tumor	NOUN
fnp-6316	178	30	diagnostics	diagnostic	NOUN
fnp-6316	178	31	still	still	ADV
fnp-6316	178	32	relies	rely	VERB
fnp-6316	178	33	on	on	ADP
fnp-6316	178	34	highly	highly	ADV
fnp-6316	178	35	invasive	invasive	ADJ
fnp-6316	178	36	procedures	procedure	NOUN
fnp-6316	178	37	to	to	PART
fnp-6316	178	38	obtain	obtain	VERB
fnp-6316	178	39	tissue	tissue	NOUN
fnp-6316	178	40	samples	sample	NOUN
fnp-6316	178	41	for	for	ADP
fnp-6316	178	42	microscopic	microscopic	ADJ
fnp-6316	178	43	or	or	CCONJ
fnp-6316	178	44	molecular	molecular	ADJ
fnp-6316	178	45	diagnostics	diagnostic	NOUN
fnp-6316	178	46	.	.	PUNCT
fnp-6316	179	1	as	as	ADP
fnp-6316	179	2	high	high	ADJ
fnp-6316	179	3	rates	rate	NOUN
fnp-6316	179	4	of	of	ADP
fnp-6316	179	5	intraoperative	intraoperative	ADJ
fnp-6316	179	6	adverse	adverse	ADJ
fnp-6316	179	7	events	event	NOUN
fnp-6316	179	8	have	have	AUX
fnp-6316	179	9	been	be	AUX
fnp-6316	179	10	reported	report	VERB
fnp-6316	179	11	for	for	ADP
fnp-6316	179	12	neurosurgical	neurosurgical	ADJ
fnp-6316	179	13	interventions	intervention	NOUN
fnp-6316	179	14	reaching	reach	VERB
fnp-6316	179	15	up	up	ADP
fnp-6316	179	16	to	to	PART
fnp-6316	179	17	40	40	NUM
fnp-6316	179	18	 	 	SPACE
fnp-6316	179	19	%	%	NOUN
fnp-6316	179	20	,	,	PUNCT
fnp-6316	179	21	there	there	PRON
fnp-6316	179	22	is	be	VERB
fnp-6316	179	23	a	a	DET
fnp-6316	179	24	strong	strong	ADJ
fnp-6316	179	25	need	need	NOUN
fnp-6316	179	26	for	for	ADP
fnp-6316	179	27	nonor	nonor	NOUN
fnp-6316	179	28	less	less	ADV
fnp-6316	179	29	invasive	invasive	ADJ
fnp-6316	179	30	diagnostic	diagnostic	ADJ
fnp-6316	179	31	procedures	procedure	NOUN
fnp-6316	179	32	in	in	ADP
fnp-6316	179	33	neurooncology	neurooncology	NOUN
fnp-6316	179	34	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	179	35	free	free	ADJ
fnp-6316	179	36	neuropathology	neuropathology	NOUN
fnp-6316	179	37	6:10	6:10	NUM
fnp-6316	179	38	(	(	PUNCT
fnp-6316	179	39	2025	2025	NUM
fnp-6316	179	40	)	)	PUNCT
fnp-6316	179	41	michel	michel	PROPN
fnp-6316	179	42	mittelbronn	mittelbronn	PROPN
fnp-6316	179	43	doi	doi	PROPN
fnp-6316	179	44	:	:	PUNCT
fnp-6316	179	45	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	179	46	page	page	NOUN
fnp-6316	179	47	12	12	NUM
fnp-6316	179	48	of	of	ADP
fnp-6316	179	49	19	19	NUM
fnp-6316	179	50	figure	figure	NOUN
fnp-6316	179	51	 	 	SPACE
fnp-6316	179	52	7	7	NUM
fnp-6316	179	53	:	:	PUNCT
fnp-6316	179	54	diagnostic	diagnostic	ADJ
fnp-6316	179	55	set	set	NOUN
fnp-6316	179	56	-	-	PUNCT
fnp-6316	179	57	up	up	NOUN
fnp-6316	179	58	and	and	CCONJ
fnp-6316	179	59	major	major	ADJ
fnp-6316	179	60	results	result	NOUN
fnp-6316	179	61	for	for	ADP
fnp-6316	179	62	clinical	clinical	ADJ
fnp-6316	179	63	phase	phase	NOUN
fnp-6316	179	64	ii	ii	NUM
fnp-6316	179	65	non	non	ADJ
fnp-6316	179	66	-	-	ADJ
fnp-6316	179	67	inferiority	inferiority	ADJ
fnp-6316	179	68	study	study	NOUN
fnp-6316	179	69	for	for	ADP
fnp-6316	179	70	intraoperative	intraoperative	ADJ
fnp-6316	179	71	neuropathological	neuropathological	ADJ
fnp-6316	179	72	assessment	assessment	NOUN
fnp-6316	179	73	using	use	VERB
fnp-6316	179	74	fluorescein	fluorescein	NOUN
fnp-6316	179	75	-	-	PUNCT
fnp-6316	179	76	stained	stain	VERB
fnp-6316	179	77	confocal	confocal	ADJ
fnp-6316	179	78	laser	laser	NOUN
fnp-6316	179	79	endomicroscopy	endomicroscopy	VERB
fnp-6316	179	80	.	.	PUNCT
fnp-6316	180	1	[	[	X
fnp-6316	180	2	drexler	drexler	NOUN
fnp-6316	180	3	et	et	PROPN
fnp-6316	180	4	al	al	PROPN
fnp-6316	180	5	.	.	PROPN
fnp-6316	180	6	,	,	PUNCT
fnp-6316	180	7	2023a	2023a	NUM
fnp-6316	180	8	]	]	PUNCT
fnp-6316	180	9	.	.	PUNCT
fnp-6316	181	1	ideally	ideally	ADV
fnp-6316	181	2	,	,	PUNCT
fnp-6316	181	3	a	a	DET
fnp-6316	181	4	non	non	ADJ
fnp-6316	181	5	-	-	ADJ
fnp-6316	181	6	operative	operative	ADJ
fnp-6316	181	7	tumor	tumor	NOUN
fnp-6316	181	8	classification	classification	NOUN
fnp-6316	181	9	could	could	AUX
fnp-6316	181	10	even	even	ADV
fnp-6316	181	11	prevent	prevent	VERB
fnp-6316	181	12	patients	patient	NOUN
fnp-6316	181	13	from	from	ADP
fnp-6316	181	14	invasive	invasive	ADJ
fnp-6316	181	15	follow	follow	NOUN
fnp-6316	181	16	-	-	PUNCT
fnp-6316	181	17	up	up	ADP
fnp-6316	181	18	procedures	procedure	NOUN
fnp-6316	181	19	as	as	ADP
fnp-6316	181	20	in	in	ADP
fnp-6316	181	21	the	the	DET
fnp-6316	181	22	case	case	NOUN
fnp-6316	181	23	of	of	ADP
fnp-6316	181	24	cns	cns	NOUN
fnp-6316	181	25	lymphoma	lymphoma	NOUN
fnp-6316	181	26	.	.	PUNCT
fnp-6316	182	1	a	a	DET
fnp-6316	182	2	second	second	ADJ
fnp-6316	182	3	important	important	ADJ
fnp-6316	182	4	reason	reason	NOUN
fnp-6316	182	5	for	for	ADP
fnp-6316	182	6	why	why	SCONJ
fnp-6316	182	7	non	non	ADJ
fnp-6316	182	8	-	-	ADJ
fnp-6316	182	9	invasive	invasive	ADJ
fnp-6316	182	10	diagnostics	diagnostic	NOUN
fnp-6316	182	11	would	would	AUX
fnp-6316	182	12	considerably	considerably	ADV
fnp-6316	182	13	improve	improve	VERB
fnp-6316	182	14	patient	patient	ADJ
fnp-6316	182	15	care	care	NOUN
fnp-6316	182	16	would	would	AUX
fnp-6316	182	17	be	be	AUX
fnp-6316	182	18	related	relate	VERB
fnp-6316	182	19	to	to	ADP
fnp-6316	182	20	the	the	DET
fnp-6316	182	21	detection	detection	NOUN
fnp-6316	182	22	of	of	ADP
fnp-6316	182	23	early	early	ADJ
fnp-6316	182	24	recurrences	recurrence	NOUN
fnp-6316	182	25	or	or	CCONJ
fnp-6316	182	26	minimal	minimal	ADJ
fnp-6316	182	27	residual	residual	ADJ
fnp-6316	182	28	tumor	tumor	NOUN
fnp-6316	182	29	load	load	NOUN
fnp-6316	182	30	.	.	PUNCT
fnp-6316	183	1	some	some	DET
fnp-6316	183	2	studies	study	NOUN
fnp-6316	183	3	have	have	AUX
fnp-6316	183	4	shown	show	VERB
fnp-6316	183	5	the	the	DET
fnp-6316	183	6	suitability	suitability	NOUN
fnp-6316	183	7	of	of	ADP
fnp-6316	183	8	sequencing	sequence	VERB
fnp-6316	183	9	techniques	technique	NOUN
fnp-6316	183	10	to	to	PART
fnp-6316	183	11	detect	detect	VERB
fnp-6316	183	12	tumor	tumor	NOUN
fnp-6316	183	13	-	-	PUNCT
fnp-6316	183	14	specific	specific	ADJ
fnp-6316	183	15	mutations	mutation	NOUN
fnp-6316	183	16	from	from	ADP
fnp-6316	183	17	cell	cell	NOUN
fnp-6316	183	18	-	-	PUNCT
fnp-6316	183	19	free	free	ADJ
fnp-6316	183	20	dna	dna	NOUN
fnp-6316	183	21	of	of	ADP
fnp-6316	183	22	the	the	DET
fnp-6316	183	23	csf	csf	NOUN
fnp-6316	183	24	in	in	ADP
fnp-6316	183	25	some	some	DET
fnp-6316	183	26	tumor	tumor	NOUN
fnp-6316	183	27	entities	entity	NOUN
fnp-6316	183	28	such	such	ADJ
fnp-6316	183	29	as	as	ADP
fnp-6316	183	30	gliomas	glioma	NOUN
fnp-6316	183	31	[	[	X
fnp-6316	183	32	miller	miller	X
fnp-6316	183	33	et	et	PROPN
fnp-6316	183	34	al	al	PROPN
fnp-6316	183	35	.	.	PROPN
fnp-6316	183	36	,	,	PUNCT
fnp-6316	183	37	2019	2019	NUM
fnp-6316	183	38	]	]	PUNCT
fnp-6316	183	39	.	.	PUNCT
fnp-6316	184	1	for	for	ADP
fnp-6316	184	2	other	other	ADJ
fnp-6316	184	3	brain	brain	NOUN
fnp-6316	184	4	tumor	tumor	NOUN
fnp-6316	184	5	entities	entity	NOUN
fnp-6316	184	6	,	,	PUNCT
fnp-6316	184	7	such	such	ADJ
fnp-6316	184	8	as	as	ADP
fnp-6316	184	9	medulloblastoma	medulloblastoma	ADJ
fnp-6316	184	10	,	,	PUNCT
fnp-6316	184	11	non	non	ADJ
fnp-6316	184	12	-	-	ADJ
fnp-6316	184	13	invasive	invasive	ADJ
fnp-6316	184	14	molecular	molecular	ADJ
fnp-6316	184	15	diagnostics	diagnostic	NOUN
fnp-6316	184	16	from	from	ADP
fnp-6316	184	17	cell	cell	NOUN
fnp-6316	184	18	-	-	PUNCT
fnp-6316	184	19	free	free	ADJ
fnp-6316	184	20	dna	dna	NOUN
fnp-6316	184	21	from	from	ADP
fnp-6316	184	22	cerebrospinal	cerebrospinal	ADJ
fnp-6316	184	23	fluid	fluid	NOUN
fnp-6316	184	24	(	(	PUNCT
fnp-6316	184	25	csf	csf	NOUN
fnp-6316	184	26	)	)	PUNCT
fnp-6316	184	27	has	have	AUX
fnp-6316	184	28	already	already	ADV
fnp-6316	184	29	been	be	AUX
fnp-6316	184	30	proven	prove	VERB
fnp-6316	184	31	to	to	PART
fnp-6316	184	32	be	be	AUX
fnp-6316	184	33	superior	superior	ADJ
fnp-6316	184	34	to	to	ADP
fnp-6316	184	35	cytological	cytological	ADJ
fnp-6316	184	36	diagnostics	diagnostic	NOUN
fnp-6316	184	37	with	with	ADP
fnp-6316	184	38	regard	regard	NOUN
fnp-6316	184	39	to	to	ADP
fnp-6316	184	40	both	both	DET
fnp-6316	184	41	the	the	DET
fnp-6316	184	42	detection	detection	NOUN
fnp-6316	184	43	of	of	ADP
fnp-6316	184	44	residual	residual	ADJ
fnp-6316	184	45	tumor	tumor	NOUN
fnp-6316	184	46	and	and	CCONJ
fnp-6316	184	47	the	the	DET
fnp-6316	184	48	prediction	prediction	NOUN
fnp-6316	184	49	of	of	ADP
fnp-6316	184	50	patient	patient	ADJ
fnp-6316	184	51	prognosis	prognosis	NOUN
fnp-6316	185	1	[	[	X
fnp-6316	185	2	liu	liu	PROPN
fnp-6316	185	3	et	et	PROPN
fnp-6316	185	4	al	al	PROPN
fnp-6316	185	5	.	.	PROPN
fnp-6316	185	6	,	,	PUNCT
fnp-6316	185	7	2021	2021	NUM
fnp-6316	185	8	]	]	PUNCT
fnp-6316	185	9	.	.	PUNCT
fnp-6316	186	1	to	to	PART
fnp-6316	186	2	evaluate	evaluate	VERB
fnp-6316	186	3	the	the	DET
fnp-6316	186	4	suitability	suitability	NOUN
fnp-6316	186	5	of	of	ADP
fnp-6316	186	6	molecular	molecular	ADJ
fnp-6316	186	7	diagnostics	diagnostic	NOUN
fnp-6316	186	8	on	on	ADP
fnp-6316	186	9	csfderived	csfderived	ADJ
fnp-6316	186	10	cell	cell	NOUN
fnp-6316	186	11	-	-	PUNCT
fnp-6316	186	12	free	free	ADJ
fnp-6316	186	13	dna	dna	NOUN
fnp-6316	186	14	across	across	ADP
fnp-6316	186	15	broader	broad	ADJ
fnp-6316	186	16	brain	brain	NOUN
fnp-6316	186	17	tumor	tumor	NOUN
fnp-6316	186	18	cohorts	cohort	NOUN
fnp-6316	186	19	,	,	PUNCT
fnp-6316	186	20	different	different	ADJ
fnp-6316	186	21	research	research	NOUN
fnp-6316	186	22	teams	team	NOUN
fnp-6316	186	23	employed	employ	VERB
fnp-6316	186	24	various	various	ADJ
fnp-6316	186	25	approaches	approach	NOUN
fnp-6316	186	26	.	.	PUNCT
fnp-6316	187	1	consequently	consequently	ADV
fnp-6316	187	2	,	,	PUNCT
fnp-6316	187	3	two	two	NUM
fnp-6316	187	4	exceptional	exceptional	ADJ
fnp-6316	187	5	papers	paper	NOUN
fnp-6316	187	6	were	be	AUX
fnp-6316	187	7	selected	select	VERB
fnp-6316	187	8	under	under	ADP
fnp-6316	187	9	a	a	DET
fnp-6316	187	10	single	single	ADJ
fnp-6316	187	11	topic	topic	NOUN
fnp-6316	187	12	.	.	PUNCT
fnp-6316	188	1	afflerbach	afflerbach	NOUN
fnp-6316	188	2	et	et	PROPN
fnp-6316	188	3	al	al	PROPN
fnp-6316	188	4	.	.	PROPN
fnp-6316	188	5	analyzed	analyze	VERB
fnp-6316	188	6	a	a	DET
fnp-6316	188	7	larger	large	ADJ
fnp-6316	188	8	cohort	cohort	NOUN
fnp-6316	188	9	of	of	ADP
fnp-6316	188	10	110	110	NUM
fnp-6316	188	11	samples	sample	NOUN
fnp-6316	188	12	from	from	ADP
fnp-6316	188	13	99	99	NUM
fnp-6316	188	14	patients	patient	NOUN
fnp-6316	188	15	with	with	ADP
fnp-6316	188	16	suspicion	suspicion	NOUN
fnp-6316	188	17	of	of	ADP
fnp-6316	188	18	primary	primary	ADJ
fnp-6316	188	19	brain	brain	NOUN
fnp-6316	188	20	tumor	tumor	NOUN
fnp-6316	188	21	using	use	VERB
fnp-6316	188	22	nanopore	nanopore	ADV
fnp-6316	188	23	sequencing	sequence	VERB
fnp-6316	188	24	(	(	PUNCT
fnp-6316	188	25	at	at	ADP
fnp-6316	188	26	least	least	ADJ
fnp-6316	188	27	5ng	5ng	ADJ
fnp-6316	188	28	dna	dna	NOUN
fnp-6316	188	29	per	per	ADP
fnp-6316	188	30	sample	sample	NOUN
fnp-6316	188	31	was	be	AUX
fnp-6316	188	32	needed	need	VERB
fnp-6316	188	33	)	)	PUNCT
fnp-6316	188	34	,	,	PUNCT
fnp-6316	188	35	a	a	DET
fnp-6316	188	36	technique	technique	NOUN
fnp-6316	188	37	which	which	PRON
fnp-6316	188	38	,	,	PUNCT
fnp-6316	188	39	in	in	ADP
fnp-6316	188	40	addition	addition	NOUN
fnp-6316	188	41	,	,	PUNCT
fnp-6316	188	42	also	also	ADV
fnp-6316	188	43	considerably	considerably	ADV
fnp-6316	188	44	reduces	reduce	VERB
fnp-6316	188	45	the	the	DET
fnp-6316	188	46	time	time	NOUN
fnp-6316	188	47	needed	need	VERB
fnp-6316	188	48	for	for	ADP
fnp-6316	188	49	sample	sample	NOUN
fnp-6316	188	50	preparation	preparation	NOUN
fnp-6316	188	51	and	and	CCONJ
fnp-6316	188	52	sequencing	sequence	VERB
fnp-6316	188	53	[	[	X
fnp-6316	188	54	afflerbach	afflerbach	NOUN
fnp-6316	188	55	et	et	NOUN
fnp-6316	188	56	al	al	PROPN
fnp-6316	188	57	.	.	PROPN
fnp-6316	188	58	,	,	PUNCT
fnp-6316	188	59	2024	2024	NUM
fnp-6316	188	60	]	]	PUNCT
fnp-6316	188	61	.	.	PUNCT
fnp-6316	189	1	in	in	ADP
fnp-6316	189	2	45	45	NUM
fnp-6316	189	3	 	 	SPACE
fnp-6316	189	4	%	%	NOUN
fnp-6316	189	5	of	of	ADP
fnp-6316	189	6	the	the	DET
fnp-6316	189	7	samples	sample	NOUN
fnp-6316	189	8	,	,	PUNCT
fnp-6316	189	9	circulating	circulate	VERB
fnp-6316	189	10	tumor	tumor	NOUN
fnp-6316	189	11	dna	dna	PROPN
fnp-6316	189	12	(	(	PUNCT
fnp-6316	189	13	ctdna	ctdna	NOUN
fnp-6316	189	14	)	)	PUNCT
fnp-6316	189	15	could	could	AUX
fnp-6316	189	16	be	be	AUX
fnp-6316	189	17	detected	detect	VERB
fnp-6316	189	18	in	in	ADP
fnp-6316	189	19	the	the	DET
fnp-6316	189	20	csf	csf	NOUN
fnp-6316	189	21	.	.	PROPN
fnp-6316	190	1	among	among	ADP
fnp-6316	190	2	the	the	DET
fnp-6316	190	3	samples	sample	NOUN
fnp-6316	190	4	in	in	ADP
fnp-6316	190	5	which	which	PRON
fnp-6316	190	6	ctdna	ctdna	NOUN
fnp-6316	190	7	was	be	AUX
fnp-6316	190	8	successfully	successfully	ADV
fnp-6316	190	9	detected	detect	VERB
fnp-6316	190	10	,	,	PUNCT
fnp-6316	190	11	only	only	ADV
fnp-6316	190	12	the	the	DET
fnp-6316	190	13	copy	copy	NOUN
fnp-6316	190	14	number	number	NOUN
fnp-6316	190	15	variation	variation	NOUN
fnp-6316	190	16	(	(	PUNCT
fnp-6316	190	17	cnv	cnv	NOUN
fnp-6316	190	18	)	)	PUNCT
fnp-6316	190	19	profile	profile	NOUN
fnp-6316	190	20	could	could	AUX
fnp-6316	190	21	be	be	AUX
fnp-6316	190	22	defined	define	VERB
fnp-6316	190	23	in	in	ADP
fnp-6316	190	24	56	56	NUM
fnp-6316	190	25	 	 	SPACE
fnp-6316	190	26	%	%	NOUN
fnp-6316	190	27	(	(	PUNCT
fnp-6316	190	28	n	n	CCONJ
fnp-6316	190	29	 	 	SPACE
fnp-6316	190	30	=	=	NOUN
fnp-6316	190	31	 	 	SPACE
fnp-6316	190	32	28	28	NUM
fnp-6316	190	33	)	)	PUNCT
fnp-6316	190	34	,	,	PUNCT
fnp-6316	190	35	only	only	ADV
fnp-6316	190	36	dna	dna	PROPN
fnp-6316	190	37	methylation	methylation	NOUN
fnp-6316	190	38	profiling	profiling	NOUN
fnp-6316	190	39	in	in	ADP
fnp-6316	190	40	12	12	NUM
fnp-6316	190	41	 	 	SPACE
fnp-6316	190	42	%	%	NOUN
fnp-6316	190	43	(	(	PUNCT
fnp-6316	190	44	n	n	CCONJ
fnp-6316	190	45	 	 	SPACE
fnp-6316	190	46	=	=	NOUN
fnp-6316	190	47	 	 	SPACE
fnp-6316	190	48	6	6	NUM
fnp-6316	190	49	)	)	PUNCT
fnp-6316	190	50	,	,	PUNCT
fnp-6316	190	51	and	and	CCONJ
fnp-6316	190	52	both	both	DET
fnp-6316	190	53	types	type	NOUN
fnp-6316	190	54	of	of	ADP
fnp-6316	190	55	information	information	NOUN
fnp-6316	190	56	in	in	ADP
fnp-6316	190	57	32	32	NUM
fnp-6316	190	58	 	 	SPACE
fnp-6316	190	59	%	%	NOUN
fnp-6316	190	60	(	(	PUNCT
fnp-6316	190	61	n	n	CCONJ
fnp-6316	190	62	 	 	SPACE
fnp-6316	190	63	=	=	NOUN
fnp-6316	190	64	 	 	SPACE
fnp-6316	190	65	16	16	NUM
fnp-6316	190	66	)	)	PUNCT
fnp-6316	190	67	.	.	PUNCT
fnp-6316	191	1	the	the	DET
fnp-6316	191	2	cnv	cnv	PROPN
fnp-6316	191	3	profile	profile	NOUN
fnp-6316	191	4	revealed	reveal	VERB
fnp-6316	191	5	several	several	ADJ
fnp-6316	191	6	diagnostically	diagnostically	ADV
fnp-6316	191	7	relevant	relevant	ADJ
fnp-6316	191	8	amplifications	amplification	NOUN
fnp-6316	191	9	as	as	ADV
fnp-6316	191	10	well	well	ADV
fnp-6316	191	11	as	as	ADP
fnp-6316	191	12	larger	large	ADJ
fnp-6316	191	13	chromosomal	chromosomal	ADJ
fnp-6316	191	14	gains	gain	NOUN
fnp-6316	191	15	and	and	CCONJ
fnp-6316	191	16	losses	loss	NOUN
fnp-6316	191	17	.	.	PUNCT
fnp-6316	192	1	of	of	ADP
fnp-6316	192	2	note	note	NOUN
fnp-6316	192	3	,	,	PUNCT
fnp-6316	192	4	corresponding	correspond	VERB
fnp-6316	192	5	cytological	cytological	ADJ
fnp-6316	192	6	analyses	analysis	NOUN
fnp-6316	192	7	detected	detect	VERB
fnp-6316	192	8	tumor	tumor	NOUN
fnp-6316	192	9	cells	cell	NOUN
fnp-6316	192	10	in	in	ADP
fnp-6316	192	11	only	only	ADV
fnp-6316	192	12	9	9	NUM
fnp-6316	192	13	cases	case	NOUN
fnp-6316	192	14	.	.	PUNCT
fnp-6316	193	1	with	with	ADP
fnp-6316	193	2	their	their	PRON
fnp-6316	193	3	groundbreaking	groundbreake	VERB
fnp-6316	193	4	study	study	NOUN
fnp-6316	193	5	,	,	PUNCT
fnp-6316	193	6	afflerbach	afflerbach	NOUN
fnp-6316	193	7	et	et	PROPN
fnp-6316	193	8	al	al	PROPN
fnp-6316	193	9	.	.	PROPN
fnp-6316	193	10	provided	provide	VERB
fnp-6316	193	11	evidence	evidence	NOUN
fnp-6316	193	12	that	that	SCONJ
fnp-6316	193	13	nanopore	nanopore	ADJ
fnp-6316	193	14	sequencing	sequencing	NOUN
fnp-6316	193	15	is	be	AUX
fnp-6316	193	16	a	a	DET
fnp-6316	193	17	fast	fast	ADJ
fnp-6316	193	18	and	and	CCONJ
fnp-6316	193	19	reliable	reliable	ADJ
fnp-6316	193	20	diagnostic	diagnostic	ADJ
fnp-6316	193	21	technique	technique	NOUN
fnp-6316	193	22	allowing	allow	VERB
fnp-6316	193	23	for	for	ADP
fnp-6316	193	24	determining	determine	VERB
fnp-6316	193	25	both	both	CCONJ
fnp-6316	193	26	cnv	cnv	NOUN
fnp-6316	193	27	and	and	CCONJ
fnp-6316	193	28	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	193	29	free	free	ADJ
fnp-6316	193	30	neuropathology	neuropathology	NOUN
fnp-6316	193	31	6:10	6:10	NUM
fnp-6316	193	32	(	(	PUNCT
fnp-6316	193	33	2025	2025	NUM
fnp-6316	193	34	)	)	PUNCT
fnp-6316	193	35	michel	michel	PROPN
fnp-6316	193	36	mittelbronn	mittelbronn	PROPN
fnp-6316	193	37	doi	doi	PROPN
fnp-6316	193	38	:	:	PUNCT
fnp-6316	193	39	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	193	40	page	page	NOUN
fnp-6316	193	41	13	13	NUM
fnp-6316	193	42	of	of	ADP
fnp-6316	193	43	19	19	NUM
fnp-6316	193	44	dna	dna	PROPN
fnp-6316	193	45	methylation	methylation	NOUN
fnp-6316	193	46	profiles	profile	NOUN
fnp-6316	193	47	from	from	ADP
fnp-6316	193	48	ctdna	ctdna	NOUN
fnp-6316	193	49	from	from	ADP
fnp-6316	193	50	csf	csf	ADJ
fnp-6316	193	51	in	in	ADP
fnp-6316	193	52	brain	brain	NOUN
fnp-6316	193	53	tumor	tumor	NOUN
fnp-6316	193	54	patients	patient	NOUN
fnp-6316	193	55	.	.	PUNCT
fnp-6316	194	1	in	in	ADP
fnp-6316	194	2	another	another	DET
fnp-6316	194	3	approach	approach	NOUN
fnp-6316	194	4	,	,	PUNCT
fnp-6316	194	5	hickman	hickman	PROPN
fnp-6316	194	6	et	et	PROPN
fnp-6316	194	7	al	al	PROPN
fnp-6316	194	8	.	.	PROPN
fnp-6316	194	9	performed	perform	VERB
fnp-6316	194	10	mutational	mutational	ADJ
fnp-6316	194	11	analyses	analysis	NOUN
fnp-6316	194	12	of	of	ADP
fnp-6316	194	13	csf	csf	ADJ
fnp-6316	194	14	circulating	circulate	VERB
fnp-6316	194	15	ctdna	ctdna	NOUN
fnp-6316	194	16	from	from	ADP
fnp-6316	194	17	711	711	NUM
fnp-6316	194	18	brain	brain	NOUN
fnp-6316	194	19	tumor	tumor	NOUN
fnp-6316	194	20	patients	patient	NOUN
fnp-6316	194	21	using	use	VERB
fnp-6316	194	22	an	an	DET
fnp-6316	194	23	fda	fda	PROPN
fnp-6316	194	24	-	-	PUNCT
fnp-6316	194	25	authorized	authorize	VERB
fnp-6316	194	26	targeting	target	VERB
fnp-6316	194	27	next	next	ADJ
fnp-6316	194	28	-	-	PUNCT
fnp-6316	194	29	generation	generation	NOUN
fnp-6316	194	30	sequencing	sequence	VERB
fnp-6316	194	31	platform	platform	NOUN
fnp-6316	195	1	[	[	X
fnp-6316	195	2	hickman	hickman	PROPN
fnp-6316	195	3	et	et	PROPN
fnp-6316	195	4	al	al	PROPN
fnp-6316	195	5	.	.	PROPN
fnp-6316	195	6	,	,	PUNCT
fnp-6316	195	7	2024	2024	NUM
fnp-6316	195	8	]	]	PUNCT
fnp-6316	195	9	.	.	PUNCT
fnp-6316	196	1	similarly	similarly	ADV
fnp-6316	196	2	to	to	ADP
fnp-6316	196	3	the	the	DET
fnp-6316	196	4	findings	finding	NOUN
fnp-6316	196	5	of	of	ADP
fnp-6316	196	6	afflerbach	afflerbach	NOUN
fnp-6316	196	7	et	et	PROPN
fnp-6316	196	8	al	al	PROPN
fnp-6316	196	9	.	.	PROPN
fnp-6316	196	10	,	,	PUNCT
fnp-6316	196	11	also	also	ADV
fnp-6316	196	12	hickman	hickman	PROPN
fnp-6316	196	13	and	and	CCONJ
fnp-6316	196	14	colleagues	colleague	NOUN
fnp-6316	196	15	detected	detect	VERB
fnp-6316	196	16	tumor	tumor	NOUN
fnp-6316	196	17	-	-	PUNCT
fnp-6316	196	18	specific	specific	ADJ
fnp-6316	196	19	mutations	mutation	NOUN
fnp-6316	196	20	in	in	ADP
fnp-6316	196	21	53	53	NUM
fnp-6316	196	22	 	 	SPACE
fnp-6316	196	23	%	%	NOUN
fnp-6316	196	24	of	of	ADP
fnp-6316	196	25	all	all	DET
fnp-6316	196	26	patient	patient	ADJ
fnp-6316	196	27	samples	sample	NOUN
fnp-6316	196	28	with	with	ADP
fnp-6316	196	29	clinically	clinically	ADV
fnp-6316	196	30	documented	document	VERB
fnp-6316	196	31	cns	cns	NOUN
fnp-6316	196	32	tumors	tumor	NOUN
fnp-6316	196	33	,	,	PUNCT
fnp-6316	196	34	whereas	whereas	SCONJ
fnp-6316	196	35	none	none	NOUN
fnp-6316	196	36	of	of	ADP
fnp-6316	196	37	the	the	DET
fnp-6316	196	38	control	control	NOUN
fnp-6316	196	39	samples	sample	NOUN
fnp-6316	196	40	showed	show	VERB
fnp-6316	196	41	a	a	DET
fnp-6316	196	42	false	false	ADJ
fnp-6316	196	43	positive	positive	ADJ
fnp-6316	196	44	result	result	NOUN
fnp-6316	196	45	,	,	PUNCT
fnp-6316	196	46	therefore	therefore	ADV
fnp-6316	196	47	constituting	constitute	VERB
fnp-6316	196	48	a	a	DET
fnp-6316	196	49	highly	highly	ADV
fnp-6316	196	50	specific	specific	ADJ
fnp-6316	196	51	diagnostic	diagnostic	ADJ
fnp-6316	196	52	approach	approach	NOUN
fnp-6316	196	53	.	.	PUNCT
fnp-6316	197	1	considering	consider	VERB
fnp-6316	197	2	the	the	DET
fnp-6316	197	3	technical	technical	ADJ
fnp-6316	197	4	limitations	limitation	NOUN
fnp-6316	197	5	of	of	ADP
fnp-6316	197	6	various	various	ADJ
fnp-6316	197	7	approaches	approach	NOUN
fnp-6316	197	8	,	,	PUNCT
fnp-6316	197	9	nanopore	nanopore	ADV
fnp-6316	197	10	-	-	PUNCT
fnp-6316	197	11	based	base	VERB
fnp-6316	197	12	sequencing	sequencing	NOUN
fnp-6316	197	13	is	be	AUX
fnp-6316	197	14	particularly	particularly	ADV
fnp-6316	197	15	constrained	constrain	VERB
fnp-6316	197	16	by	by	ADP
fnp-6316	197	17	low	low	ADJ
fnp-6316	197	18	genomic	genomic	NOUN
fnp-6316	197	19	coverage	coverage	NOUN
fnp-6316	197	20	,	,	PUNCT
fnp-6316	197	21	making	make	VERB
fnp-6316	197	22	it	it	PRON
fnp-6316	197	23	unsuitable	unsuitable	ADJ
fnp-6316	197	24	for	for	ADP
fnp-6316	197	25	the	the	DET
fnp-6316	197	26	reliable	reliable	ADJ
fnp-6316	197	27	detection	detection	NOUN
fnp-6316	197	28	of	of	ADP
fnp-6316	197	29	point	point	NOUN
fnp-6316	197	30	mutations	mutation	NOUN
fnp-6316	197	31	[	[	X
fnp-6316	197	32	emiliani	emiliani	X
fnp-6316	197	33	et	et	PROPN
fnp-6316	197	34	al	al	PROPN
fnp-6316	197	35	.	.	PROPN
fnp-6316	197	36	,	,	PUNCT
fnp-6316	197	37	2025	2025	NUM
fnp-6316	197	38	]	]	PUNCT
fnp-6316	197	39	.	.	PUNCT
fnp-6316	198	1	moreover	moreover	ADV
fnp-6316	198	2	,	,	PUNCT
fnp-6316	198	3	since	since	SCONJ
fnp-6316	198	4	short	short	NOUN
fnp-6316	198	5	-	-	PUNCT
fnp-6316	198	6	read	read	VERB
fnp-6316	198	7	next	next	ADJ
fnp-6316	198	8	-	-	PUNCT
fnp-6316	198	9	generation	generation	NOUN
fnp-6316	198	10	sequencing	sequence	VERB
fnp-6316	198	11	techniques	technique	NOUN
fnp-6316	198	12	have	have	AUX
fnp-6316	198	13	successfully	successfully	ADV
fnp-6316	198	14	identified	identify	VERB
fnp-6316	198	15	tumor	tumor	NOUN
fnp-6316	198	16	-	-	PUNCT
fnp-6316	198	17	specific	specific	ADJ
fnp-6316	198	18	mutations	mutation	NOUN
fnp-6316	198	19	with	with	ADP
fnp-6316	198	20	as	as	ADV
fnp-6316	198	21	little	little	ADJ
fnp-6316	198	22	as	as	ADP
fnp-6316	198	23	0.1	0.1	NUM
fnp-6316	198	24	ng	ng	PROPN
fnp-6316	198	25	of	of	ADP
fnp-6316	198	26	cell	cell	NOUN
fnp-6316	198	27	-	-	PUNCT
fnp-6316	198	28	free	free	ADJ
fnp-6316	198	29	dna	dna	NOUN
fnp-6316	198	30	from	from	ADP
fnp-6316	198	31	csf	csf	PROPN
fnp-6316	198	32	,	,	PUNCT
fnp-6316	198	33	a	a	DET
fnp-6316	198	34	methodological	methodological	ADJ
fnp-6316	198	35	comparison	comparison	NOUN
fnp-6316	198	36	of	of	ADP
fnp-6316	198	37	different	different	ADJ
fnp-6316	198	38	sequencing	sequencing	NOUN
fnp-6316	198	39	techniques	technique	NOUN
fnp-6316	198	40	is	be	AUX
fnp-6316	198	41	essential	essential	ADJ
fnp-6316	198	42	to	to	PART
fnp-6316	198	43	determine	determine	VERB
fnp-6316	198	44	the	the	DET
fnp-6316	198	45	most	most	ADV
fnp-6316	198	46	suitable	suitable	ADJ
fnp-6316	198	47	approach	approach	NOUN
fnp-6316	198	48	[	[	X
fnp-6316	198	49	miller	miller	PROPN
fnp-6316	198	50	et	et	PROPN
fnp-6316	198	51	al	al	PROPN
fnp-6316	198	52	.	.	PROPN
fnp-6316	198	53	,	,	PUNCT
fnp-6316	198	54	2022	2022	NUM
fnp-6316	198	55	]	]	PUNCT
fnp-6316	198	56	.	.	PUNCT
fnp-6316	199	1	these	these	DET
fnp-6316	199	2	approaches	approach	NOUN
fnp-6316	199	3	will	will	AUX
fnp-6316	199	4	considerably	considerably	ADV
fnp-6316	199	5	change	change	VERB
fnp-6316	199	6	our	our	PRON
fnp-6316	199	7	initial	initial	ADJ
fnp-6316	199	8	diagnostic	diagnostic	ADJ
fnp-6316	199	9	approach	approach	NOUN
fnp-6316	199	10	and	and	CCONJ
fnp-6316	199	11	treatment	treatment	NOUN
fnp-6316	199	12	survey	survey	NOUN
fnp-6316	199	13	in	in	ADP
fnp-6316	199	14	neurooncology	neurooncology	NOUN
fnp-6316	199	15	in	in	ADP
fnp-6316	199	16	the	the	DET
fnp-6316	199	17	future	future	NOUN
fnp-6316	199	18	.	.	PUNCT
fnp-6316	200	1	9	9	X
fnp-6316	200	2	.	.	NOUN
fnp-6316	200	3	time	time	NOUN
fnp-6316	200	4	-	-	PUNCT
fnp-6316	200	5	dependent	dependent	ADJ
fnp-6316	200	6	single	single	ADJ
fnp-6316	200	7	-	-	PUNCT
fnp-6316	200	8	cell	cell	NOUN
fnp-6316	200	9	phenotyping	phenotyping	NOUN
fnp-6316	200	10	of	of	ADP
fnp-6316	200	11	immune	immune	ADJ
fnp-6316	200	12	cells	cell	NOUN
fnp-6316	200	13	in	in	ADP
fnp-6316	200	14	glioblastoma	glioblastoma	NOUN
fnp-6316	201	1	[	[	X
fnp-6316	201	2	kirschenbaum	kirschenbaum	NOUN
fnp-6316	201	3	et	et	PROPN
fnp-6316	201	4	al	al	PROPN
fnp-6316	201	5	.	.	PROPN
fnp-6316	201	6	,	,	PUNCT
fnp-6316	201	7	2024	2024	NUM
fnp-6316	201	8	]	]	PUNCT
fnp-6316	201	9	single	single	ADJ
fnp-6316	201	10	cell	cell	NOUN
fnp-6316	201	11	rna	rna	NOUN
fnp-6316	201	12	sequencing	sequencing	NOUN
fnp-6316	201	13	techniques	technique	NOUN
fnp-6316	201	14	revolutionized	revolutionize	VERB
fnp-6316	201	15	the	the	DET
fnp-6316	201	16	understanding	understanding	NOUN
fnp-6316	201	17	of	of	ADP
fnp-6316	201	18	individual	individual	ADJ
fnp-6316	201	19	cell	cell	NOUN
fnp-6316	201	20	states	state	NOUN
fnp-6316	201	21	about	about	ADP
fnp-6316	201	22	which	which	PRON
fnp-6316	201	23	one	one	PRON
fnp-6316	201	24	could	could	AUX
fnp-6316	201	25	only	only	ADV
fnp-6316	201	26	speculate	speculate	VERB
fnp-6316	201	27	from	from	ADP
fnp-6316	201	28	data	datum	NOUN
fnp-6316	201	29	derived	derive	VERB
fnp-6316	201	30	from	from	ADP
fnp-6316	201	31	bulk	bulk	ADJ
fnp-6316	201	32	sequencing	sequencing	NOUN
fnp-6316	202	1	[	[	X
fnp-6316	202	2	ramsköld	ramsköld	NOUN
fnp-6316	202	3	et	et	PROPN
fnp-6316	202	4	al	al	PROPN
fnp-6316	202	5	.	.	PROPN
fnp-6316	202	6	,	,	PUNCT
fnp-6316	202	7	2012	2012	NUM
fnp-6316	202	8	;	;	PUNCT
fnp-6316	202	9	tang	tang	X
fnp-6316	202	10	et	et	PROPN
fnp-6316	202	11	al	al	PROPN
fnp-6316	202	12	.	.	PROPN
fnp-6316	202	13	,	,	PUNCT
fnp-6316	202	14	2009	2009	NUM
fnp-6316	202	15	]	]	PUNCT
fnp-6316	202	16	.	.	PUNCT
fnp-6316	203	1	however	however	ADV
fnp-6316	203	2	,	,	PUNCT
fnp-6316	203	3	it	it	PRON
fnp-6316	203	4	is	be	AUX
fnp-6316	203	5	still	still	ADV
fnp-6316	203	6	challenging	challenge	VERB
fnp-6316	203	7	to	to	ADP
fnp-6316	203	8	decipher	decipher	NOUN
fnp-6316	203	9	how	how	SCONJ
fnp-6316	203	10	cell	cell	NOUN
fnp-6316	203	11	states	state	NOUN
fnp-6316	203	12	change	change	VERB
fnp-6316	203	13	over	over	ADP
fnp-6316	203	14	time	time	NOUN
fnp-6316	203	15	under	under	ADP
fnp-6316	203	16	distinct	distinct	ADJ
fnp-6316	203	17	conditions	condition	NOUN
fnp-6316	203	18	,	,	PUNCT
fnp-6316	203	19	such	such	ADJ
fnp-6316	203	20	as	as	ADP
fnp-6316	203	21	for	for	ADP
fnp-6316	203	22	example	example	NOUN
fnp-6316	203	23	the	the	DET
fnp-6316	203	24	effect	effect	NOUN
fnp-6316	203	25	of	of	ADP
fnp-6316	203	26	the	the	DET
fnp-6316	203	27	tumor	tumor	NOUN
fnp-6316	203	28	microenvironment	microenvironment	NOUN
fnp-6316	203	29	on	on	ADP
fnp-6316	203	30	infiltrating	infiltrating	ADJ
fnp-6316	203	31	immune	immune	ADJ
fnp-6316	203	32	cells	cell	NOUN
fnp-6316	203	33	.	.	PUNCT
fnp-6316	204	1	to	to	PART
fnp-6316	204	2	address	address	VERB
fnp-6316	204	3	this	this	DET
fnp-6316	204	4	question	question	NOUN
fnp-6316	204	5	,	,	PUNCT
fnp-6316	204	6	kirschenbaum	kirschenbaum	PROPN
fnp-6316	204	7	et	et	PROPN
fnp-6316	204	8	al	al	PROPN
fnp-6316	204	9	.	.	PROPN
fnp-6316	204	10	developed	develop	VERB
fnp-6316	204	11	a	a	DET
fnp-6316	204	12	new	new	ADJ
fnp-6316	204	13	method	method	NOUN
fnp-6316	204	14	called	call	VERB
fnp-6316	204	15	zman	zman	NOUN
fnp-6316	204	16	sequencing	sequencing	NOUN
fnp-6316	204	17	(	(	PUNCT
fnp-6316	204	18	“	"	PUNCT
fnp-6316	204	19	zman	zman	NOUN
fnp-6316	204	20	”	"	PUNCT
fnp-6316	204	21	is	be	AUX
fnp-6316	204	22	the	the	DET
fnp-6316	204	23	phonetic	phonetic	ADJ
fnp-6316	204	24	spelling	spelling	NOUN
fnp-6316	204	25	of	of	ADP
fnp-6316	204	26	the	the	DET
fnp-6316	204	27	hebrew	hebrew	ADJ
fnp-6316	204	28	word	word	NOUN
fnp-6316	204	29	for	for	ADP
fnp-6316	204	30	“	"	PUNCT
fnp-6316	204	31	time	time	NOUN
fnp-6316	204	32	”	"	PUNCT
fnp-6316	204	33	)	)	PUNCT
fnp-6316	204	34	which	which	PRON
fnp-6316	204	35	combines	combine	VERB
fnp-6316	204	36	the	the	DET
fnp-6316	204	37	use	use	NOUN
fnp-6316	204	38	of	of	ADP
fnp-6316	204	39	fluorophore	fluorophore	NOUN
fnp-6316	204	40	pulse	pulse	NOUN
fnp-6316	204	41	labels	label	NOUN
fnp-6316	204	42	in	in	ADP
fnp-6316	204	43	the	the	DET
fnp-6316	204	44	blood	blood	NOUN
fnp-6316	204	45	as	as	ADP
fnp-6316	204	46	temporal	temporal	ADJ
fnp-6316	204	47	stamps	stamp	NOUN
fnp-6316	204	48	with	with	ADP
fnp-6316	204	49	single	single	ADJ
fnp-6316	204	50	cell	cell	NOUN
fnp-6316	204	51	rna	rna	NOUN
fnp-6316	204	52	sequencing	sequence	VERB
fnp-6316	204	53	[	[	X
fnp-6316	204	54	kirschenbaum	kirschenbaum	NOUN
fnp-6316	204	55	et	et	PROPN
fnp-6316	204	56	al	al	PROPN
fnp-6316	204	57	.	.	PROPN
fnp-6316	204	58	,	,	PUNCT
fnp-6316	204	59	2024	2024	NUM
fnp-6316	204	60	]	]	PUNCT
fnp-6316	204	61	.	.	PUNCT
fnp-6316	205	1	the	the	DET
fnp-6316	205	2	authors	author	NOUN
fnp-6316	205	3	intravenously	intravenously	ADV
fnp-6316	205	4	applied	apply	VERB
fnp-6316	205	5	four	four	NUM
fnp-6316	205	6	times	time	NOUN
fnp-6316	205	7	an	an	DET
fnp-6316	205	8	identical	identical	ADJ
fnp-6316	205	9	antibody	antibody	NOUN
fnp-6316	205	10	directed	direct	VERB
fnp-6316	205	11	against	against	ADP
fnp-6316	205	12	cd45	cd45	PROPN
fnp-6316	205	13	that	that	SCONJ
fnp-6316	205	14	,	,	PUNCT
fnp-6316	205	15	however	however	ADV
fnp-6316	205	16	,	,	PUNCT
fnp-6316	205	17	was	be	AUX
fnp-6316	205	18	labeled	label	VERB
fnp-6316	205	19	each	each	DET
fnp-6316	205	20	time	time	NOUN
fnp-6316	205	21	with	with	ADP
fnp-6316	205	22	a	a	DET
fnp-6316	205	23	different	different	ADJ
fnp-6316	205	24	fluorophore	fluorophore	NOUN
fnp-6316	205	25	(	(	PUNCT
fnp-6316	205	26	n	n	CCONJ
fnp-6316	205	27	 	 	SPACE
fnp-6316	205	28	=	=	NOUN
fnp-6316	205	29	 	 	SPACE
fnp-6316	205	30	4	4	NUM
fnp-6316	205	31	in	in	ADP
fnp-6316	205	32	total	total	NOUN
fnp-6316	205	33	)	)	PUNCT
fnp-6316	205	34	in	in	ADP
fnp-6316	205	35	12h	12h	NUM
fnp-6316	205	36	intervals	interval	NOUN
fnp-6316	205	37	(	(	PUNCT
fnp-6316	205	38	between	between	ADP
fnp-6316	205	39	24	24	NUM
fnp-6316	205	40	-	-	PUNCT
fnp-6316	205	41	60h	60h	NUM
fnp-6316	205	42	or	or	CCONJ
fnp-6316	205	43	12	12	NUM
fnp-6316	205	44	-	-	PUNCT
fnp-6316	205	45	48h	48h	NOUN
fnp-6316	205	46	before	before	SCONJ
fnp-6316	205	47	mice	mouse	NOUN
fnp-6316	205	48	were	be	AUX
fnp-6316	205	49	sacrificed	sacrifice	VERB
fnp-6316	205	50	)	)	PUNCT
fnp-6316	205	51	.	.	PUNCT
fnp-6316	206	1	after	after	ADP
fnp-6316	206	2	having	having	AUX
fnp-6316	206	3	confirmed	confirm	VERB
fnp-6316	206	4	that	that	SCONJ
fnp-6316	206	5	the	the	DET
fnp-6316	206	6	fluorophore	fluorophore	NOUN
fnp-6316	206	7	-	-	PUNCT
fnp-6316	206	8	coupled	couple	VERB
fnp-6316	206	9	antibodies	antibody	NOUN
fnp-6316	206	10	(	(	PUNCT
fnp-6316	206	11	a	a	X
fnp-6316	206	12	)	)	PUNCT
fnp-6316	206	13	almost	almost	ADV
fnp-6316	206	14	exclusively	exclusively	ADV
fnp-6316	206	15	stain	stain	NOUN
fnp-6316	206	16	immune	immune	ADJ
fnp-6316	206	17	cells	cell	NOUN
fnp-6316	206	18	in	in	ADP
fnp-6316	206	19	the	the	DET
fnp-6316	206	20	blood	blood	NOUN
fnp-6316	206	21	stream	stream	NOUN
fnp-6316	206	22	,	,	PUNCT
fnp-6316	206	23	(	(	PUNCT
fnp-6316	206	24	b	b	X
fnp-6316	206	25	)	)	PUNCT
fnp-6316	206	26	can	can	AUX
fnp-6316	206	27	be	be	AUX
fnp-6316	206	28	reliably	reliably	ADV
fnp-6316	206	29	detected	detect	VERB
fnp-6316	206	30	on	on	ADP
fnp-6316	206	31	immune	immune	ADJ
fnp-6316	206	32	cells	cell	NOUN
fnp-6316	206	33	over	over	ADP
fnp-6316	206	34	96h	96h	NUM
fnp-6316	206	35	,	,	PUNCT
fnp-6316	206	36	(	(	PUNCT
fnp-6316	206	37	c	c	X
fnp-6316	206	38	)	)	PUNCT
fnp-6316	206	39	do	do	AUX
fnp-6316	206	40	not	not	PART
fnp-6316	206	41	penetrate	penetrate	VERB
fnp-6316	206	42	the	the	DET
fnp-6316	206	43	brain	brain	NOUN
fnp-6316	206	44	and	and	CCONJ
fnp-6316	206	45	(	(	PUNCT
fnp-6316	206	46	d	d	X
fnp-6316	206	47	)	)	PUNCT
fnp-6316	206	48	are	be	AUX
fnp-6316	206	49	virtually	virtually	ADV
fnp-6316	206	50	completely	completely	ADV
fnp-6316	206	51	degraded	degrade	VERB
fnp-6316	206	52	in	in	ADP
fnp-6316	206	53	the	the	DET
fnp-6316	206	54	blood	blood	NOUN
fnp-6316	206	55	within	within	ADP
fnp-6316	206	56	60	60	NUM
fnp-6316	206	57	-	-	SYM
fnp-6316	206	58	90	90	NUM
fnp-6316	206	59	min	min	NOUN
fnp-6316	206	60	,	,	PUNCT
fnp-6316	206	61	transcriptional	transcriptional	ADJ
fnp-6316	206	62	molecular	molecular	ADJ
fnp-6316	206	63	trajectories	trajectory	NOUN
fnp-6316	206	64	of	of	ADP
fnp-6316	206	65	natural	natural	ADJ
fnp-6316	206	66	killer	killer	NOUN
fnp-6316	206	67	(	(	PUNCT
fnp-6316	206	68	nk	nk	PROPN
fnp-6316	206	69	)	)	PUNCT
fnp-6316	206	70	and	and	CCONJ
fnp-6316	206	71	myeloid	myeloid	ADJ
fnp-6316	206	72	cells	cell	NOUN
fnp-6316	206	73	in	in	ADP
fnp-6316	206	74	the	the	DET
fnp-6316	206	75	syngeneic	syngeneic	ADJ
fnp-6316	206	76	gl261	gl261	PROPN
fnp-6316	206	77	murine	murine	ADJ
fnp-6316	206	78	glioblastoma	glioblastoma	NOUN
fnp-6316	206	79	model	model	NOUN
fnp-6316	206	80	were	be	AUX
fnp-6316	206	81	assessed	assess	VERB
fnp-6316	206	82	.	.	PUNCT
fnp-6316	207	1	one	one	PRON
fnp-6316	207	2	can	can	AUX
fnp-6316	207	3	assume	assume	VERB
fnp-6316	207	4	that	that	SCONJ
fnp-6316	207	5	cd45	cd45	PROPN
fnp-6316	207	6	-	-	PUNCT
fnp-6316	207	7	positive	positive	ADJ
fnp-6316	207	8	immune	immune	ADJ
fnp-6316	207	9	cells	cell	NOUN
fnp-6316	207	10	labeled	label	VERB
fnp-6316	207	11	with	with	ADP
fnp-6316	207	12	one	one	NUM
fnp-6316	207	13	of	of	ADP
fnp-6316	207	14	the	the	DET
fnp-6316	207	15	four	four	NUM
fnp-6316	207	16	distinct	distinct	ADJ
fnp-6316	207	17	fluorophores	fluorophore	NOUN
fnp-6316	207	18	encountering	encounter	VERB
fnp-6316	207	19	in	in	ADP
fnp-6316	207	20	the	the	DET
fnp-6316	207	21	glioma	glioma	NOUN
fnp-6316	207	22	tumor	tumor	NOUN
fnp-6316	207	23	microenvironment	microenvironment	NOUN
fnp-6316	207	24	mostly	mostly	ADV
fnp-6316	207	25	infiltrated	infiltrate	VERB
fnp-6316	207	26	the	the	DET
fnp-6316	207	27	brain	brain	NOUN
fnp-6316	207	28	via	via	ADP
fnp-6316	207	29	the	the	DET
fnp-6316	207	30	blood	blood	NOUN
fnp-6316	207	31	stream	stream	NOUN
fnp-6316	207	32	within	within	ADP
fnp-6316	207	33	a	a	DET
fnp-6316	207	34	time	time	NOUN
fnp-6316	207	35	frame	frame	NOUN
fnp-6316	207	36	of	of	ADP
fnp-6316	207	37	+	+	NOUN
fnp-6316	207	38	/12h	/12h	PROPN
fnp-6316	207	39	before	before	ADP
fnp-6316	207	40	the	the	DET
fnp-6316	207	41	application	application	NOUN
fnp-6316	207	42	of	of	ADP
fnp-6316	207	43	the	the	DET
fnp-6316	207	44	next	next	ADJ
fnp-6316	207	45	,	,	PUNCT
fnp-6316	207	46	subsequent	subsequent	ADJ
fnp-6316	207	47	fluorophore	fluorophore	NOUN
fnp-6316	207	48	-	-	PUNCT
fnp-6316	207	49	labeled	label	VERB
fnp-6316	207	50	antibody	antibody	NOUN
fnp-6316	207	51	.	.	PUNCT
fnp-6316	208	1	with	with	ADP
fnp-6316	208	2	this	this	DET
fnp-6316	208	3	approach	approach	NOUN
fnp-6316	208	4	,	,	PUNCT
fnp-6316	208	5	a	a	DET
fnp-6316	208	6	temporal	temporal	ADJ
fnp-6316	208	7	transcriptional	transcriptional	ADJ
fnp-6316	208	8	kinetic	kinetic	NOUN
fnp-6316	208	9	profile	profile	NOUN
fnp-6316	208	10	can	can	AUX
fnp-6316	208	11	be	be	AUX
fnp-6316	208	12	calculated	calculate	VERB
fnp-6316	208	13	for	for	ADP
fnp-6316	208	14	each	each	DET
fnp-6316	208	15	immune	immune	ADJ
fnp-6316	208	16	cell	cell	NOUN
fnp-6316	208	17	type	type	NOUN
fnp-6316	208	18	within	within	ADP
fnp-6316	208	19	the	the	DET
fnp-6316	208	20	glioma	glioma	NOUN
fnp-6316	208	21	microenvironment	microenvironment	NOUN
fnp-6316	208	22	.	.	PUNCT
fnp-6316	209	1	of	of	ADP
fnp-6316	209	2	note	note	NOUN
fnp-6316	209	3	,	,	PUNCT
fnp-6316	209	4	primary	primary	ADJ
fnp-6316	209	5	microglia	microglia	NOUN
fnp-6316	209	6	are	be	AUX
fnp-6316	209	7	mostly	mostly	ADV
fnp-6316	209	8	not	not	PART
fnp-6316	209	9	stained	stain	VERB
fnp-6316	209	10	by	by	ADP
fnp-6316	209	11	this	this	DET
fnp-6316	209	12	approach	approach	NOUN
fnp-6316	209	13	as	as	ADP
fnp-6316	209	14	the	the	DET
fnp-6316	209	15	intravenously	intravenously	ADV
fnp-6316	209	16	injected	inject	VERB
fnp-6316	209	17	fluorophore	fluorophore	NOUN
fnp-6316	209	18	-	-	PUNCT
fnp-6316	209	19	coupled	couple	VERB
fnp-6316	209	20	antibodies	antibody	NOUN
fnp-6316	209	21	did	do	AUX
fnp-6316	209	22	not	not	PART
fnp-6316	209	23	penetrate	penetrate	VERB
fnp-6316	209	24	the	the	DET
fnp-6316	209	25	brain	brain	NOUN
fnp-6316	209	26	.	.	PUNCT
fnp-6316	210	1	with	with	ADP
fnp-6316	210	2	this	this	DET
fnp-6316	210	3	approach	approach	NOUN
fnp-6316	210	4	,	,	PUNCT
fnp-6316	210	5	the	the	DET
fnp-6316	210	6	authors	author	NOUN
fnp-6316	210	7	showed	show	VERB
fnp-6316	210	8	that	that	SCONJ
fnp-6316	210	9	nk	nk	PROPN
fnp-6316	210	10	cells	cell	NOUN
fnp-6316	210	11	changed	change	VERB
fnp-6316	210	12	from	from	ADP
fnp-6316	210	13	a	a	DET
fnp-6316	210	14	cytotoxic	cytotoxic	NOUN
fnp-6316	210	15	to	to	ADP
fnp-6316	210	16	a	a	DET
fnp-6316	210	17	dysfunctional	dysfunctional	ADJ
fnp-6316	210	18	,	,	PUNCT
fnp-6316	210	19	and	and	CCONJ
fnp-6316	210	20	myeloid	myeloid	ADJ
fnp-6316	210	21	cells	cell	NOUN
fnp-6316	210	22	from	from	ADP
fnp-6316	210	23	classic	classic	ADJ
fnp-6316	210	24	monocytes	monocyte	NOUN
fnp-6316	210	25	to	to	ADP
fnp-6316	210	26	i	i	PRON
fnp-6316	210	27	m	m	VERB
fnp-6316	210	28	munosuppressive	munosuppressive	ADJ
fnp-6316	210	29	tumor	tumor	NOUN
fnp-6316	210	30	-	-	PUNCT
fnp-6316	210	31	associated	associate	VERB
fnp-6316	210	32	macrophages	macrophage	NOUN
fnp-6316	210	33	(	(	PUNCT
fnp-6316	210	34	tam	tam	NOUN
fnp-6316	210	35	)	)	PUNCT
fnp-6316	210	36	via	via	ADP
fnp-6316	210	37	activated	activate	VERB
fnp-6316	210	38	tgf-1	tgf-1	NOUN
fnp-6316	210	39	signaling	signal	VERB
fnp-6316	210	40	within	within	ADP
fnp-6316	210	41	24h	24h	NOUN
fnp-6316	210	42	and	and	CCONJ
fnp-6316	210	43	36	36	NUM
fnp-6316	210	44	-	-	NOUN
fnp-6316	210	45	48h	48h	NOUN
fnp-6316	210	46	,	,	PUNCT
fnp-6316	210	47	respectively	respectively	ADV
fnp-6316	210	48	.	.	PUNCT
fnp-6316	211	1	as	as	SCONJ
fnp-6316	211	2	tgf-1	tgf-1	NOUN
fnp-6316	211	3	signaling	signal	VERB
fnp-6316	211	4	was	be	AUX
fnp-6316	211	5	associated	associate	VERB
fnp-6316	211	6	with	with	ADP
fnp-6316	211	7	trem2	trem2	NOUN
fnp-6316	211	8	activation	activation	NOUN
fnp-6316	211	9	in	in	ADP
fnp-6316	211	10	immune	immune	ADJ
fnp-6316	211	11	cells	cell	NOUN
fnp-6316	211	12	of	of	ADP
fnp-6316	211	13	the	the	DET
fnp-6316	211	14	myeloid	myeloid	ADJ
fnp-6316	211	15	lineage	lineage	NOUN
fnp-6316	211	16	,	,	PUNCT
fnp-6316	211	17	an	an	DET
fnp-6316	211	18	immunotherapeutic	immunotherapeutic	ADJ
fnp-6316	211	19	approach	approach	NOUN
fnp-6316	211	20	with	with	ADP
fnp-6316	211	21	an	an	DET
fnp-6316	211	22	anti	anti	ADJ
fnp-6316	211	23	-	-	ADJ
fnp-6316	211	24	trem2	trem2	ADJ
fnp-6316	211	25	antibody	antibody	NOUN
fnp-6316	211	26	was	be	AUX
fnp-6316	211	27	performed	perform	VERB
fnp-6316	211	28	in	in	ADP
fnp-6316	211	29	the	the	DET
fnp-6316	211	30	gl261	gl261	PROPN
fnp-6316	211	31	glioma	glioma	NOUN
fnp-6316	211	32	model	model	NOUN
fnp-6316	211	33	.	.	PUNCT
fnp-6316	212	1	this	this	DET
fnp-6316	212	2	treatment	treatment	NOUN
fnp-6316	212	3	prevented	prevent	VERB
fnp-6316	212	4	the	the	DET
fnp-6316	212	5	differentiation	differentiation	NOUN
fnp-6316	212	6	to	to	ADP
fnp-6316	212	7	immunosuppressive	immunosuppressive	ADJ
fnp-6316	212	8	tams	tam	NOUN
fnp-6316	212	9	leading	lead	VERB
fnp-6316	212	10	to	to	ADP
fnp-6316	212	11	a	a	DET
fnp-6316	212	12	pro	pro	ADJ
fnp-6316	212	13	-	-	ADJ
fnp-6316	212	14	inflammatory	inflammatory	ADJ
fnp-6316	212	15	cell	cell	NOUN
fnp-6316	212	16	state	state	NOUN
fnp-6316	212	17	that	that	PRON
fnp-6316	212	18	is	be	AUX
fnp-6316	212	19	supposed	suppose	VERB
fnp-6316	212	20	to	to	PART
fnp-6316	212	21	possess	possess	VERB
fnp-6316	212	22	a	a	DET
fnp-6316	212	23	much	much	ADV
fnp-6316	212	24	stronger	strong	ADJ
fnp-6316	212	25	anti	anti	ADJ
fnp-6316	212	26	-	-	ADJ
fnp-6316	212	27	tumoral	tumoral	ADJ
fnp-6316	212	28	properties	property	NOUN
fnp-6316	212	29	by	by	ADP
fnp-6316	212	30	recruiting	recruit	VERB
fnp-6316	212	31	t	t	PROPN
fnp-6316	212	32	and	and	CCONJ
fnp-6316	212	33	nk	nk	PROPN
fnp-6316	212	34	cells	cell	NOUN
fnp-6316	212	35	[	[	X
fnp-6316	212	36	allen	allen	X
fnp-6316	212	37	et	et	PROPN
fnp-6316	212	38	al	al	PROPN
fnp-6316	212	39	.	.	PROPN
fnp-6316	212	40	,	,	PUNCT
fnp-6316	212	41	2017	2017	NUM
fnp-6316	212	42	]	]	PUNCT
fnp-6316	212	43	.	.	PUNCT
fnp-6316	213	1	with	with	ADP
fnp-6316	213	2	their	their	PRON
fnp-6316	213	3	study	study	NOUN
fnp-6316	213	4	,	,	PUNCT
fnp-6316	213	5	kirschenbaum	kirschenbaum	PROPN
fnp-6316	213	6	et	et	PROPN
fnp-6316	213	7	al	al	PROPN
fnp-6316	213	8	.	.	PROPN
fnp-6316	213	9	provide	provide	VERB
fnp-6316	213	10	a	a	DET
fnp-6316	213	11	revolutionary	revolutionary	ADJ
fnp-6316	213	12	technique	technique	NOUN
fnp-6316	213	13	allowing	allow	VERB
fnp-6316	213	14	for	for	ADP
fnp-6316	213	15	deciphering	decipher	VERB
fnp-6316	213	16	the	the	DET
fnp-6316	213	17	transcriptional	transcriptional	ADJ
fnp-6316	213	18	trajectories	trajectory	NOUN
fnp-6316	213	19	of	of	ADP
fnp-6316	213	20	immune	immune	ADJ
fnp-6316	213	21	cells	cell	NOUN
fnp-6316	213	22	from	from	ADP
fnp-6316	213	23	the	the	DET
fnp-6316	213	24	blood	blood	NOUN
fnp-6316	213	25	stream	stream	NOUN
fnp-6316	213	26	.	.	PUNCT
fnp-6316	214	1	they	they	PRON
fnp-6316	214	2	nicely	nicely	ADV
fnp-6316	214	3	apply	apply	VERB
fnp-6316	214	4	this	this	DET
fnp-6316	214	5	method	method	NOUN
fnp-6316	214	6	to	to	PART
fnp-6316	214	7	assess	assess	VERB
fnp-6316	214	8	the	the	DET
fnp-6316	214	9	impact	impact	NOUN
fnp-6316	214	10	of	of	ADP
fnp-6316	214	11	the	the	DET
fnp-6316	214	12	glioma	glioma	NOUN
fnp-6316	214	13	microenvironment	microenvironment	NOUN
fnp-6316	214	14	on	on	ADP
fnp-6316	214	15	infiltrating	infiltrating	ADJ
fnp-6316	214	16	immune	immune	ADJ
fnp-6316	214	17	cells	cell	NOUN
fnp-6316	214	18	showing	show	VERB
fnp-6316	214	19	that	that	SCONJ
fnp-6316	214	20	the	the	DET
fnp-6316	214	21	tumor	tumor	NOUN
fnp-6316	214	22	mostly	mostly	ADV
fnp-6316	214	23	escapes	escape	VERB
fnp-6316	214	24	from	from	ADP
fnp-6316	214	25	an	an	DET
fnp-6316	214	26	immune	immune	ADJ
fnp-6316	214	27	attack	attack	NOUN
fnp-6316	214	28	by	by	ADP
fnp-6316	214	29	inhibiting	inhibit	VERB
fnp-6316	214	30	nk	nk	PROPN
fnp-6316	214	31	and	and	CCONJ
fnp-6316	214	32	myeloid	myeloid	ADJ
fnp-6316	214	33	cells	cell	NOUN
fnp-6316	214	34	via	via	ADP
fnp-6316	214	35	tgf-1	tgf-1	NOUN
fnp-6316	214	36	-	-	PUNCT
fnp-6316	214	37	activated	activate	VERB
fnp-6316	214	38	pathways	pathway	NOUN
fnp-6316	214	39	.	.	PUNCT
fnp-6316	215	1	finally	finally	ADV
fnp-6316	215	2	,	,	PUNCT
fnp-6316	215	3	they	they	PRON
fnp-6316	215	4	provide	provide	VERB
fnp-6316	215	5	a	a	DET
fnp-6316	215	6	smart	smart	ADJ
fnp-6316	215	7	initial	initial	ADJ
fnp-6316	215	8	therapeutic	therapeutic	ADJ
fnp-6316	215	9	approach	approach	NOUN
fnp-6316	215	10	by	by	ADP
fnp-6316	215	11	preventing	prevent	VERB
fnp-6316	215	12	myeloid	myeloid	ADJ
fnp-6316	215	13	cells	cell	NOUN
fnp-6316	215	14	to	to	PART
fnp-6316	215	15	acquire	acquire	VERB
fnp-6316	215	16	a	a	DET
fnp-6316	215	17	pro	pro	ADJ
fnp-6316	215	18	-	-	ADJ
fnp-6316	215	19	tumorigenic	tumorigenic	ADJ
fnp-6316	215	20	cell	cell	NOUN
fnp-6316	215	21	state	state	NOUN
fnp-6316	215	22	applying	apply	VERB
fnp-6316	215	23	an	an	DET
fnp-6316	215	24	anti	anti	ADJ
fnp-6316	215	25	-	-	ADJ
fnp-6316	215	26	trem2	trem2	ADJ
fnp-6316	215	27	antibody	antibody	NOUN
fnp-6316	215	28	(	(	PUNCT
fnp-6316	215	29	for	for	ADP
fnp-6316	215	30	summary	summary	NOUN
fnp-6316	215	31	see	see	VERB
fnp-6316	215	32	figure	figure	NOUN
fnp-6316	215	33	 	 	SPACE
fnp-6316	215	34	8)	8)	NUM
fnp-6316	215	35	.	.	PUNCT
fnp-6316	216	1	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	216	2	free	free	ADJ
fnp-6316	216	3	neuropathology	neuropathology	NOUN
fnp-6316	216	4	6:10	6:10	NUM
fnp-6316	216	5	(	(	PUNCT
fnp-6316	216	6	2025	2025	NUM
fnp-6316	216	7	)	)	PUNCT
fnp-6316	216	8	michel	michel	PROPN
fnp-6316	216	9	mittelbronn	mittelbronn	PROPN
fnp-6316	216	10	doi	doi	PROPN
fnp-6316	216	11	:	:	PUNCT
fnp-6316	216	12	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	216	13	page	page	NOUN
fnp-6316	216	14	14	14	NUM
fnp-6316	216	15	of	of	ADP
fnp-6316	216	16	19	19	NUM
fnp-6316	216	17	figure	figure	NOUN
fnp-6316	216	18	 	 	SPACE
fnp-6316	216	19	8	8	NUM
fnp-6316	216	20	:	:	PUNCT
fnp-6316	216	21	time	time	NOUN
fnp-6316	216	22	-	-	PUNCT
fnp-6316	216	23	dependent	dependent	ADJ
fnp-6316	216	24	immune	immune	ADJ
fnp-6316	216	25	cells	cell	NOUN
fnp-6316	216	26	transcriptomics	transcriptomic	NOUN
fnp-6316	216	27	in	in	ADP
fnp-6316	216	28	glioblastoma	glioblastoma	NOUN
fnp-6316	216	29	.	.	PUNCT
fnp-6316	217	1	left	leave	VERB
fnp-6316	217	2	side	side	NOUN
fnp-6316	217	3	:	:	PUNCT
fnp-6316	217	4	methodological	methodological	ADJ
fnp-6316	217	5	set	set	NOUN
fnp-6316	217	6	-	-	PUNCT
fnp-6316	217	7	up	up	NOUN
fnp-6316	217	8	.	.	PUNCT
fnp-6316	218	1	right	right	ADJ
fnp-6316	218	2	side	side	NOUN
fnp-6316	218	3	:	:	PUNCT
fnp-6316	218	4	major	major	ADJ
fnp-6316	218	5	findings	finding	NOUN
fnp-6316	218	6	of	of	ADP
fnp-6316	218	7	nk	nk	PROPN
fnp-6316	218	8	and	and	CCONJ
fnp-6316	218	9	myeloid	myeloid	ADJ
fnp-6316	218	10	cell	cell	NOUN
fnp-6316	218	11	/	/	SYM
fnp-6316	218	12	tam	tam	NOUN
fnp-6316	218	13	transcriptional	transcriptional	NOUN
fnp-6316	218	14	trajectories	trajectory	NOUN
fnp-6316	218	15	.	.	PUNCT
fnp-6316	219	1	10	10	X
fnp-6316	219	2	.	.	X
fnp-6316	219	3	histone	histone	NOUN
fnp-6316	219	4	serotonylation	serotonylation	PROPN
fnp-6316	219	5	regulates	regulate	VERB
fnp-6316	219	6	ependymoma	ependymoma	NOUN
fnp-6316	219	7	tumorigenesis	tumorigenesis	NOUN
fnp-6316	220	1	[	[	X
fnp-6316	220	2	chen	chen	PROPN
fnp-6316	220	3	et	et	PROPN
fnp-6316	220	4	al	al	PROPN
fnp-6316	220	5	.	.	PROPN
fnp-6316	220	6	,	,	PUNCT
fnp-6316	220	7	2024	2024	NUM
fnp-6316	220	8	]	]	PUNCT
fnp-6316	220	9	ependymomas	ependymomas	AUX
fnp-6316	220	10	constitute	constitute	VERB
fnp-6316	220	11	a	a	DET
fnp-6316	220	12	heterogeneous	heterogeneous	ADJ
fnp-6316	220	13	group	group	NOUN
fnp-6316	220	14	of	of	ADP
fnp-6316	220	15	cns	cns	PROPN
fnp-6316	220	16	tumors	tumor	NOUN
fnp-6316	220	17	that	that	PRON
fnp-6316	220	18	are	be	AUX
fnp-6316	220	19	currently	currently	ADV
fnp-6316	220	20	classified	classify	VERB
fnp-6316	220	21	into	into	ADP
fnp-6316	220	22	at	at	ADV
fnp-6316	220	23	least	least	ADV
fnp-6316	220	24	nine	nine	NUM
fnp-6316	220	25	distinct	distinct	ADJ
fnp-6316	220	26	molecular	molecular	ADJ
fnp-6316	220	27	subtypes	subtype	NOUN
fnp-6316	220	28	and	and	CCONJ
fnp-6316	220	29	are	be	AUX
fnp-6316	220	30	partly	partly	ADV
fnp-6316	220	31	considered	consider	VERB
fnp-6316	220	32	an	an	DET
fnp-6316	220	33	epigenetic	epigenetic	ADJ
fnp-6316	220	34	disorder	disorder	NOUN
fnp-6316	220	35	[	[	X
fnp-6316	220	36	stuckert	stuckert	X
fnp-6316	220	37	et	et	PROPN
fnp-6316	220	38	al	al	PROPN
fnp-6316	220	39	.	.	PROPN
fnp-6316	220	40	,	,	PUNCT
fnp-6316	220	41	2020	2020	NUM
fnp-6316	220	42	]	]	PUNCT
fnp-6316	220	43	.	.	PUNCT
fnp-6316	221	1	as	as	SCONJ
fnp-6316	221	2	recent	recent	ADJ
fnp-6316	221	3	studies	study	NOUN
fnp-6316	221	4	have	have	AUX
fnp-6316	221	5	revealed	reveal	VERB
fnp-6316	221	6	a	a	DET
fnp-6316	221	7	direct	direct	ADJ
fnp-6316	221	8	epigenetic	epigenetic	ADJ
fnp-6316	221	9	modification	modification	NOUN
fnp-6316	221	10	of	of	ADP
fnp-6316	221	11	histone	histone	NOUN
fnp-6316	221	12	h3	h3	NOUN
fnp-6316	221	13	by	by	ADP
fnp-6316	221	14	serotonin	serotonin	NOUN
fnp-6316	221	15	,	,	PUNCT
fnp-6316	221	16	a	a	DET
fnp-6316	221	17	process	process	NOUN
fnp-6316	221	18	termed	term	VERB
fnp-6316	221	19	'	'	PUNCT
fnp-6316	221	20	serotonylation	serotonylation	NOUN
fnp-6316	221	21	,	,	PUNCT
fnp-6316	221	22	'	'	PUNCT
fnp-6316	221	23	a	a	DET
fnp-6316	221	24	potential	potential	ADJ
fnp-6316	221	25	link	link	NOUN
fnp-6316	221	26	between	between	ADP
fnp-6316	221	27	serotonin	serotonin	NOUN
fnp-6316	221	28	-	-	PUNCT
fnp-6316	221	29	induced	induce	VERB
fnp-6316	221	30	histone	histone	NOUN
fnp-6316	221	31	alterations	alteration	NOUN
fnp-6316	221	32	and	and	CCONJ
fnp-6316	221	33	the	the	DET
fnp-6316	221	34	development	development	NOUN
fnp-6316	221	35	and	and	CCONJ
fnp-6316	221	36	progression	progression	NOUN
fnp-6316	221	37	of	of	ADP
fnp-6316	221	38	ependymoma	ependymoma	NOUN
fnp-6316	221	39	has	have	AUX
fnp-6316	221	40	been	be	AUX
fnp-6316	221	41	hypothesized	hypothesize	VERB
fnp-6316	222	1	[	[	PUNCT
fnp-6316	222	2	farrelly	farrelly	NOUN
fnp-6316	222	3	et	et	PROPN
fnp-6316	222	4	al	al	PROPN
fnp-6316	222	5	.	.	PROPN
fnp-6316	222	6	,	,	PUNCT
fnp-6316	222	7	2019	2019	NUM
fnp-6316	222	8	]	]	PUNCT
fnp-6316	222	9	.	.	PUNCT
fnp-6316	223	1	to	to	PART
fnp-6316	223	2	address	address	VERB
fnp-6316	223	3	this	this	DET
fnp-6316	223	4	hypothesis	hypothesis	NOUN
fnp-6316	223	5	,	,	PUNCT
fnp-6316	223	6	chen	chen	PROPN
fnp-6316	223	7	et	et	PROPN
fnp-6316	223	8	al	al	PROPN
fnp-6316	223	9	.	.	PROPN
fnp-6316	223	10	generated	generate	VERB
fnp-6316	223	11	ependymomas	ependymomas	PROPN
fnp-6316	223	12	by	by	ADP
fnp-6316	223	13	performing	perform	VERB
fnp-6316	223	14	in	in	ADP
fnp-6316	223	15	utero	utero	ADJ
fnp-6316	223	16	electroporation	electroporation	NOUN
fnp-6316	223	17	to	to	PART
fnp-6316	223	18	insert	insert	VERB
fnp-6316	223	19	the	the	DET
fnp-6316	223	20	zfta	zfta	PROPN
fnp-6316	223	21	-	-	PUNCT
fnp-6316	223	22	rela	rela	ADJ
fnp-6316	223	23	fusion	fusion	NOUN
fnp-6316	223	24	gene	gene	NOUN
fnp-6316	223	25	and	and	CCONJ
fnp-6316	223	26	knock	knock	VERB
fnp-6316	223	27	out	out	ADP
fnp-6316	223	28	trp53	trp53	PROPN
fnp-6316	223	29	,	,	PUNCT
fnp-6316	223	30	a	a	DET
fnp-6316	223	31	tumor	tumor	NOUN
fnp-6316	223	32	suppressor	suppressor	NOUN
fnp-6316	223	33	gene	gene	NOUN
fnp-6316	223	34	.	.	PUNCT
fnp-6316	224	1	additionally	additionally	ADV
fnp-6316	224	2	,	,	PUNCT
fnp-6316	224	3	a	a	DET
fnp-6316	224	4	designer	designer	NOUN
fnp-6316	224	5	receptor	receptor	NOUN
fnp-6316	224	6	exclusively	exclusively	ADV
fnp-6316	224	7	activated	activate	VERB
fnp-6316	224	8	by	by	ADP
fnp-6316	224	9	designer	designer	NOUN
fnp-6316	224	10	drugs	drug	NOUN
fnp-6316	224	11	(	(	PUNCT
fnp-6316	224	12	dreadd	dreadd	NOUN
fnp-6316	224	13	)	)	PUNCT
fnp-6316	224	14	approach	approach	NOUN
fnp-6316	224	15	was	be	AUX
fnp-6316	224	16	employed	employ	VERB
fnp-6316	224	17	to	to	PART
fnp-6316	224	18	modulate	modulate	VERB
fnp-6316	224	19	neuronal	neuronal	ADJ
fnp-6316	224	20	activity	activity	NOUN
fnp-6316	224	21	in	in	ADP
fnp-6316	224	22	cortical	cortical	ADJ
fnp-6316	224	23	neurons	neuron	NOUN
fnp-6316	224	24	and	and	CCONJ
fnp-6316	224	25	dorsal	dorsal	NOUN
fnp-6316	224	26	raphe	raphe	NOUN
fnp-6316	224	27	nucleus	nucleus	NOUN
fnp-6316	224	28	neurons	neuron	NOUN
fnp-6316	224	29	.	.	PUNCT
fnp-6316	225	1	this	this	PRON
fnp-6316	225	2	was	be	AUX
fnp-6316	225	3	achieved	achieve	VERB
fnp-6316	225	4	by	by	ADP
fnp-6316	225	5	injecting	inject	VERB
fnp-6316	225	6	non	non	ADJ
fnp-6316	225	7	-	-	ADJ
fnp-6316	225	8	naturally	naturally	ADV
fnp-6316	225	9	occurring	occur	VERB
fnp-6316	225	10	receptors	receptor	NOUN
fnp-6316	225	11	into	into	ADP
fnp-6316	225	12	distinct	distinct	ADJ
fnp-6316	225	13	brain	brain	NOUN
fnp-6316	225	14	areas	area	NOUN
fnp-6316	225	15	via	via	ADP
fnp-6316	225	16	viral	viral	ADJ
fnp-6316	225	17	vectors	vector	NOUN
fnp-6316	225	18	,	,	PUNCT
fnp-6316	225	19	which	which	PRON
fnp-6316	225	20	were	be	AUX
fnp-6316	225	21	subsequently	subsequently	ADV
fnp-6316	225	22	activated	activate	VERB
fnp-6316	225	23	by	by	ADP
fnp-6316	225	24	a	a	DET
fnp-6316	225	25	synthetic	synthetic	ADJ
fnp-6316	225	26	ligand	ligand	NOUN
fnp-6316	225	27	.	.	PUNCT
fnp-6316	226	1	the	the	DET
fnp-6316	226	2	authors	author	NOUN
fnp-6316	226	3	showed	show	VERB
fnp-6316	226	4	that	that	SCONJ
fnp-6316	226	5	the	the	DET
fnp-6316	226	6	activation	activation	NOUN
fnp-6316	226	7	of	of	ADP
fnp-6316	226	8	excitatory	excitatory	ADJ
fnp-6316	226	9	cortical	cortical	ADJ
fnp-6316	226	10	neurons	neuron	NOUN
fnp-6316	226	11	promoted	promote	VERB
fnp-6316	226	12	the	the	DET
fnp-6316	226	13	development	development	NOUN
fnp-6316	226	14	of	of	ADP
fnp-6316	226	15	zfta	zfta	PROPN
fnp-6316	226	16	-	-	PUNCT
fnp-6316	226	17	rela	rela	ADJ
fnp-6316	226	18	fusion	fusion	NOUN
fnp-6316	226	19	-	-	PUNCT
fnp-6316	226	20	driven	drive	VERB
fnp-6316	226	21	ependymomas	ependymoma	NOUN
fnp-6316	226	22	and	and	CCONJ
fnp-6316	226	23	identified	identify	VERB
fnp-6316	226	24	serotonergic	serotonergic	ADJ
fnp-6316	226	25	activity	activity	NOUN
fnp-6316	226	26	in	in	ADP
fnp-6316	226	27	the	the	DET
fnp-6316	226	28	dorsal	dorsal	NOUN
fnp-6316	226	29	raphe	raphe	NOUN
fnp-6316	226	30	nucleus	nucleus	NOUN
fnp-6316	226	31	–	–	PUNCT
fnp-6316	226	32	an	an	DET
fnp-6316	226	33	area	area	NOUN
fnp-6316	226	34	remote	remote	ADJ
fnp-6316	226	35	from	from	ADP
fnp-6316	226	36	the	the	DET
fnp-6316	226	37	ependymoma	ependymoma	NOUN
fnp-6316	226	38	–	–	PUNCT
fnp-6316	226	39	as	as	ADP
fnp-6316	226	40	a	a	DET
fnp-6316	226	41	suppressive	suppressive	ADJ
fnp-6316	226	42	factor	factor	NOUN
fnp-6316	226	43	for	for	ADP
fnp-6316	226	44	ependymoma	ependymoma	NOUN
fnp-6316	226	45	progression	progression	NOUN
fnp-6316	226	46	.	.	PUNCT
fnp-6316	227	1	however	however	ADV
fnp-6316	227	2	,	,	PUNCT
fnp-6316	227	3	established	establish	VERB
fnp-6316	227	4	,	,	PUNCT
fnp-6316	227	5	both	both	DET
fnp-6316	227	6	murine	murine	ADJ
fnp-6316	227	7	and	and	CCONJ
fnp-6316	227	8	human	human	ADJ
fnp-6316	227	9	ependymoma	ependymoma	NOUN
fnp-6316	227	10	cells	cell	NOUN
fnp-6316	227	11	also	also	ADV
fnp-6316	227	12	displayed	display	VERB
fnp-6316	227	13	a	a	DET
fnp-6316	227	14	considerable	considerable	ADJ
fnp-6316	227	15	higher	high	ADJ
fnp-6316	227	16	amount	amount	NOUN
fnp-6316	227	17	of	of	ADP
fnp-6316	227	18	serotonylated	serotonylate	VERB
fnp-6316	227	19	h3	h3	NOUN
fnp-6316	227	20	compared	compare	VERB
fnp-6316	227	21	to	to	ADP
fnp-6316	227	22	normal	normal	ADJ
fnp-6316	227	23	cns	cns	NOUN
fnp-6316	227	24	tissue	tissue	NOUN
fnp-6316	227	25	and	and	CCONJ
fnp-6316	227	26	histone	histone	NOUN
fnp-6316	227	27	serotonylation	serotonylation	NOUN
fnp-6316	227	28	was	be	AUX
fnp-6316	227	29	associated	associate	VERB
fnp-6316	227	30	with	with	ADP
fnp-6316	227	31	tumor	tumor	NOUN
fnp-6316	227	32	progression	progression	NOUN
fnp-6316	227	33	,	,	PUNCT
fnp-6316	227	34	providing	provide	VERB
fnp-6316	227	35	evidence	evidence	NOUN
fnp-6316	227	36	that	that	PRON
fnp-6316	227	37	serotonin	serotonin	AUX
fnp-6316	227	38	signaling	signal	VERB
fnp-6316	227	39	may	may	AUX
fnp-6316	227	40	have	have	VERB
fnp-6316	227	41	a	a	DET
fnp-6316	227	42	rather	rather	ADV
fnp-6316	227	43	disparate	disparate	ADJ
fnp-6316	227	44	role	role	NOUN
fnp-6316	227	45	in	in	ADP
fnp-6316	227	46	ependymoma	ependymoma	NOUN
fnp-6316	227	47	tumor	tumor	NOUN
fnp-6316	227	48	biology	biology	NOUN
fnp-6316	227	49	.	.	PUNCT
fnp-6316	228	1	in	in	ADP
fnp-6316	228	2	the	the	DET
fnp-6316	228	3	experimental	experimental	ADJ
fnp-6316	228	4	setting	setting	NOUN
fnp-6316	228	5	,	,	PUNCT
fnp-6316	228	6	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	228	7	free	free	ADJ
fnp-6316	228	8	neuropathology	neuropathology	NOUN
fnp-6316	228	9	6:10	6:10	NUM
fnp-6316	228	10	(	(	PUNCT
fnp-6316	228	11	2025	2025	NUM
fnp-6316	228	12	)	)	PUNCT
fnp-6316	228	13	michel	michel	PROPN
fnp-6316	228	14	mittelbronn	mittelbronn	PROPN
fnp-6316	228	15	doi	doi	PROPN
fnp-6316	228	16	:	:	PUNCT
fnp-6316	228	17	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	228	18	page	page	NOUN
fnp-6316	228	19	15	15	NUM
fnp-6316	228	20	of	of	ADP
fnp-6316	228	21	19	19	NUM
fnp-6316	228	22	figure	figure	NOUN
fnp-6316	228	23	 	 	SPACE
fnp-6316	228	24	9	9	NUM
fnp-6316	228	25	:	:	PUNCT
fnp-6316	228	26	disparate	disparate	ADJ
fnp-6316	228	27	effects	effect	NOUN
fnp-6316	228	28	of	of	ADP
fnp-6316	228	29	serotonin	serotonin	NOUN
fnp-6316	228	30	in	in	ADP
fnp-6316	228	31	ependymoma	ependymoma	NOUN
fnp-6316	228	32	tumorigenesis	tumorigenesis	NOUN
fnp-6316	228	33	.	.	PUNCT
fnp-6316	229	1	on	on	ADP
fnp-6316	229	2	the	the	DET
fnp-6316	229	3	one	one	NUM
fnp-6316	229	4	hand	hand	NOUN
fnp-6316	229	5	,	,	PUNCT
fnp-6316	229	6	serotonin	serotonin	VERB
fnp-6316	229	7	signaling	signal	VERB
fnp-6316	229	8	from	from	ADP
fnp-6316	229	9	the	the	DET
fnp-6316	229	10	dorsal	dorsal	NOUN
fnp-6316	229	11	raphe	raphe	NOUN
fnp-6316	229	12	nucleus	nucleus	PROPN
fnp-6316	229	13	inhibits	inhibit	VERB
fnp-6316	229	14	remote	remote	ADJ
fnp-6316	229	15	ependymoma	ependymoma	NOUN
fnp-6316	229	16	growth	growth	NOUN
fnp-6316	229	17	,	,	PUNCT
fnp-6316	229	18	most	most	ADV
fnp-6316	229	19	likely	likely	ADJ
fnp-6316	229	20	by	by	ADP
fnp-6316	229	21	reducing	reduce	VERB
fnp-6316	229	22	neuronal	neuronal	ADJ
fnp-6316	229	23	activity	activity	NOUN
fnp-6316	229	24	in	in	ADP
fnp-6316	229	25	the	the	DET
fnp-6316	229	26	tumor	tumor	NOUN
fnp-6316	229	27	microenvironment	microenvironment	NOUN
fnp-6316	229	28	.	.	PUNCT
fnp-6316	230	1	on	on	ADP
fnp-6316	230	2	the	the	DET
fnp-6316	230	3	other	other	ADJ
fnp-6316	230	4	hand	hand	NOUN
fnp-6316	230	5	,	,	PUNCT
fnp-6316	230	6	tumor	tumor	NOUN
fnp-6316	230	7	cell	cell	NOUN
fnp-6316	230	8	-	-	PUNCT
fnp-6316	230	9	intrinsic	intrinsic	ADJ
fnp-6316	230	10	serotonylation	serotonylation	NOUN
fnp-6316	230	11	promotes	promote	VERB
fnp-6316	230	12	ependymoma	ependymoma	NOUN
fnp-6316	230	13	growth	growth	NOUN
fnp-6316	230	14	through	through	ADP
fnp-6316	230	15	epigenetic	epigenetic	ADJ
fnp-6316	230	16	modification	modification	NOUN
fnp-6316	230	17	and	and	CCONJ
fnp-6316	230	18	subsequent	subsequent	ADJ
fnp-6316	230	19	etv5	etv5	PROPN
fnp-6316	230	20	overexpression	overexpression	NOUN
fnp-6316	230	21	,	,	PUNCT
fnp-6316	230	22	ultimately	ultimately	ADV
fnp-6316	230	23	leading	lead	VERB
fnp-6316	230	24	to	to	ADP
fnp-6316	230	25	neuropeptide	neuropeptide	VERB
fnp-6316	230	26	y	y	PROPN
fnp-6316	230	27	(	(	PUNCT
fnp-6316	230	28	npy	npy	PROPN
fnp-6316	230	29	)	)	PUNCT
fnp-6316	230	30	inhibition	inhibition	NOUN
fnp-6316	230	31	.	.	PUNCT
fnp-6316	231	1	as	as	ADP
fnp-6316	231	2	a	a	DET
fnp-6316	231	3	result	result	NOUN
fnp-6316	231	4	,	,	PUNCT
fnp-6316	231	5	the	the	DET
fnp-6316	231	6	inhibitory	inhibitory	ADJ
fnp-6316	231	7	effect	effect	NOUN
fnp-6316	231	8	of	of	ADP
fnp-6316	231	9	npy	npy	PROPN
fnp-6316	231	10	on	on	ADP
fnp-6316	231	11	brain	brain	NOUN
fnp-6316	231	12	activity	activity	NOUN
fnp-6316	231	13	and	and	CCONJ
fnp-6316	231	14	its	its	PRON
fnp-6316	231	15	tumor	tumor	NOUN
fnp-6316	231	16	-	-	PUNCT
fnp-6316	231	17	suppressive	suppressive	NOUN
fnp-6316	231	18	function	function	NOUN
fnp-6316	231	19	are	be	AUX
fnp-6316	231	20	abolished	abolish	VERB
fnp-6316	231	21	.	.	PUNCT
fnp-6316	232	1	ets	et	NOUN
fnp-6316	232	2	transcription	transcription	NOUN
fnp-6316	232	3	variant	variant	NOUN
fnp-6316	232	4	factor	factor	NOUN
fnp-6316	232	5	5	5	NUM
fnp-6316	232	6	(	(	PUNCT
fnp-6316	232	7	etv5	etv5	PROPN
fnp-6316	232	8	)	)	PUNCT
fnp-6316	232	9	,	,	PUNCT
fnp-6316	232	10	a	a	DET
fnp-6316	232	11	transcription	transcription	NOUN
fnp-6316	232	12	factor	factor	NOUN
fnp-6316	232	13	with	with	ADP
fnp-6316	232	14	binding	bind	VERB
fnp-6316	232	15	sites	site	NOUN
fnp-6316	232	16	for	for	ADP
fnp-6316	232	17	both	both	CCONJ
fnp-6316	232	18	serotonylated	serotonylate	VERB
fnp-6316	232	19	h3	h3	NOUN
fnp-6316	232	20	and	and	CCONJ
fnp-6316	232	21	the	the	DET
fnp-6316	232	22	zfta	zfta	PROPN
fnp-6316	232	23	-	-	PUNCT
fnp-6316	232	24	rela	rela	PROPN
fnp-6316	232	25	fusion	fusion	NOUN
fnp-6316	232	26	,	,	PUNCT
fnp-6316	232	27	was	be	AUX
fnp-6316	232	28	identified	identify	VERB
fnp-6316	232	29	as	as	ADP
fnp-6316	232	30	a	a	DET
fnp-6316	232	31	tumor	tumor	NOUN
fnp-6316	232	32	-	-	PUNCT
fnp-6316	232	33	promoting	promote	VERB
fnp-6316	232	34	factor	factor	NOUN
fnp-6316	232	35	.	.	PUNCT
fnp-6316	233	1	the	the	DET
fnp-6316	233	2	authors	author	NOUN
fnp-6316	233	3	further	far	ADV
fnp-6316	233	4	demonstrated	demonstrate	VERB
fnp-6316	233	5	that	that	SCONJ
fnp-6316	233	6	etv5	etv5	PROPN
fnp-6316	233	7	was	be	AUX
fnp-6316	233	8	associated	associate	VERB
fnp-6316	233	9	with	with	ADP
fnp-6316	233	10	a	a	DET
fnp-6316	233	11	repressive	repressive	ADJ
fnp-6316	233	12	h3k27	h3k27	ADJ
fnp-6316	233	13	trimethylation	trimethylation	NOUN
fnp-6316	233	14	signature	signature	NOUN
fnp-6316	233	15	and	and	CCONJ
fnp-6316	233	16	decreased	decrease	VERB
fnp-6316	233	17	neuropeptide	neuropeptide	ADJ
fnp-6316	233	18	y	y	PROPN
fnp-6316	233	19	(	(	PUNCT
fnp-6316	233	20	npy	npy	PROPN
fnp-6316	233	21	)	)	PUNCT
fnp-6316	233	22	expression	expression	NOUN
fnp-6316	233	23	in	in	ADP
fnp-6316	233	24	ependymoma	ependymoma	NOUN
fnp-6316	233	25	.	.	PUNCT
fnp-6316	234	1	moreover	moreover	ADV
fnp-6316	234	2	,	,	PUNCT
fnp-6316	234	3	etv5	etv5	PROPN
fnp-6316	234	4	overexpression	overexpression	NOUN
fnp-6316	234	5	abrogated	abrogate	VERB
fnp-6316	234	6	npy	npy	ADV
fnp-6316	234	7	-	-	PUNCT
fnp-6316	234	8	mediated	mediate	VERB
fnp-6316	234	9	synaptic	synaptic	ADJ
fnp-6316	234	10	inhibition	inhibition	NOUN
fnp-6316	234	11	in	in	ADP
fnp-6316	234	12	the	the	DET
fnp-6316	234	13	tumor	tumor	NOUN
fnp-6316	234	14	microenvironment	microenvironment	NOUN
fnp-6316	234	15	,	,	PUNCT
fnp-6316	234	16	which	which	PRON
fnp-6316	234	17	was	be	AUX
fnp-6316	234	18	linked	link	VERB
fnp-6316	234	19	to	to	ADP
fnp-6316	234	20	reduced	reduce	VERB
fnp-6316	234	21	tumor	tumor	NOUN
fnp-6316	234	22	growth	growth	NOUN
fnp-6316	234	23	(	(	PUNCT
fnp-6316	234	24	figure	figure	NOUN
fnp-6316	234	25	 	 	SPACE
fnp-6316	234	26	9	9	NUM
fnp-6316	234	27	)	)	PUNCT
fnp-6316	234	28	.	.	PUNCT
fnp-6316	235	1	discussion	discussion	NOUN
fnp-6316	235	2	the	the	DET
fnp-6316	235	3	body	body	NOUN
fnp-6316	235	4	of	of	ADP
fnp-6316	235	5	research	research	NOUN
fnp-6316	235	6	published	publish	VERB
fnp-6316	235	7	in	in	ADP
fnp-6316	235	8	2024	2024	NUM
fnp-6316	235	9	reveals	reveal	VERB
fnp-6316	235	10	significant	significant	ADJ
fnp-6316	235	11	advancements	advancement	NOUN
fnp-6316	235	12	in	in	ADP
fnp-6316	235	13	the	the	DET
fnp-6316	235	14	understanding	understanding	NOUN
fnp-6316	235	15	of	of	ADP
fnp-6316	235	16	glioblastoma	glioblastoma	NOUN
fnp-6316	235	17	and	and	CCONJ
fnp-6316	235	18	brain	brain	NOUN
fnp-6316	235	19	metastasis	metastasis	NOUN
fnp-6316	235	20	,	,	PUNCT
fnp-6316	235	21	with	with	ADP
fnp-6316	235	22	a	a	DET
fnp-6316	235	23	particular	particular	ADJ
fnp-6316	235	24	emphasis	emphasis	NOUN
fnp-6316	235	25	on	on	ADP
fnp-6316	235	26	tumor	tumor	NOUN
fnp-6316	235	27	heterogeneity	heterogeneity	NOUN
fnp-6316	235	28	,	,	PUNCT
fnp-6316	235	29	diagnostic	diagnostic	ADJ
fnp-6316	235	30	advancements	advancement	NOUN
fnp-6316	235	31	,	,	PUNCT
fnp-6316	235	32	and	and	CCONJ
fnp-6316	235	33	therapeutic	therapeutic	ADJ
fnp-6316	235	34	implications	implication	NOUN
fnp-6316	235	35	.	.	PUNCT
fnp-6316	236	1	the	the	DET
fnp-6316	236	2	studies	study	NOUN
fnp-6316	236	3	covered	cover	VERB
fnp-6316	236	4	in	in	ADP
fnp-6316	236	5	this	this	DET
fnp-6316	236	6	overview	overview	NOUN
fnp-6316	236	7	contribute	contribute	VERB
fnp-6316	236	8	to	to	ADP
fnp-6316	236	9	refining	refine	VERB
fnp-6316	236	10	our	our	PRON
fnp-6316	236	11	approaches	approach	NOUN
fnp-6316	236	12	to	to	ADP
fnp-6316	236	13	both	both	CCONJ
fnp-6316	236	14	the	the	DET
fnp-6316	236	15	molecular	molecular	ADJ
fnp-6316	236	16	and	and	CCONJ
fnp-6316	236	17	clinical	clinical	ADJ
fnp-6316	236	18	management	management	NOUN
fnp-6316	236	19	of	of	ADP
fnp-6316	236	20	brain	brain	NOUN
fnp-6316	236	21	tumors	tumor	NOUN
fnp-6316	236	22	,	,	PUNCT
fnp-6316	236	23	highlighting	highlight	VERB
fnp-6316	236	24	critical	critical	ADJ
fnp-6316	236	25	challenges	challenge	NOUN
fnp-6316	236	26	and	and	CCONJ
fnp-6316	236	27	innovative	innovative	ADJ
fnp-6316	236	28	solutions	solution	NOUN
fnp-6316	236	29	.	.	PUNCT
fnp-6316	237	1	a	a	DET
fnp-6316	237	2	major	major	ADJ
fnp-6316	237	3	theme	theme	NOUN
fnp-6316	237	4	emerging	emerge	VERB
fnp-6316	237	5	from	from	ADP
fnp-6316	237	6	this	this	DET
fnp-6316	237	7	year	year	NOUN
fnp-6316	237	8	's	's	PART
fnp-6316	237	9	literature	literature	NOUN
fnp-6316	237	10	is	be	AUX
fnp-6316	237	11	the	the	DET
fnp-6316	237	12	growing	grow	VERB
fnp-6316	237	13	recognition	recognition	NOUN
fnp-6316	237	14	of	of	ADP
fnp-6316	237	15	the	the	DET
fnp-6316	237	16	microenvironment	microenvironment	NOUN
fnp-6316	237	17	's	's	PART
fnp-6316	237	18	role	role	NOUN
fnp-6316	237	19	in	in	ADP
fnp-6316	237	20	tumor	tumor	NOUN
fnp-6316	237	21	progression	progression	NOUN
fnp-6316	237	22	.	.	PUNCT
fnp-6316	238	1	roesler	roesler	NOUN
fnp-6316	238	2	et	et	PROPN
fnp-6316	238	3	al	al	PROPN
fnp-6316	238	4	.	.	PROPN
fnp-6316	238	5	demonstrate	demonstrate	VERB
fnp-6316	238	6	the	the	DET
fnp-6316	238	7	pivotal	pivotal	ADJ
fnp-6316	238	8	impact	impact	NOUN
fnp-6316	238	9	of	of	ADP
fnp-6316	238	10	altered	altered	ADJ
fnp-6316	238	11	cerebral	cerebral	ADJ
fnp-6316	238	12	microcirculation	microcirculation	NOUN
fnp-6316	238	13	and	and	CCONJ
fnp-6316	238	14	a	a	DET
fnp-6316	238	15	hypoxic	hypoxic	ADJ
fnp-6316	238	16	-	-	PUNCT
fnp-6316	238	17	ischemic	ischemic	ADJ
fnp-6316	238	18	microenvironment	microenvironment	NOUN
fnp-6316	238	19	in	in	ADP
fnp-6316	238	20	the	the	DET
fnp-6316	238	21	development	development	NOUN
fnp-6316	238	22	of	of	ADP
fnp-6316	238	23	brain	brain	NOUN
fnp-6316	238	24	metastases	metastasis	NOUN
fnp-6316	238	25	[	[	X
fnp-6316	238	26	roesler	roesler	NOUN
fnp-6316	238	27	et	et	PROPN
fnp-6316	238	28	al	al	PROPN
fnp-6316	238	29	.	.	PROPN
fnp-6316	238	30	,	,	PUNCT
fnp-6316	238	31	2024	2024	NUM
fnp-6316	238	32	]	]	PUNCT
fnp-6316	238	33	.	.	PUNCT
fnp-6316	239	1	their	their	PRON
fnp-6316	239	2	findings	finding	NOUN
fnp-6316	239	3	underscore	underscore	VERB
fnp-6316	239	4	the	the	DET
fnp-6316	239	5	importance	importance	NOUN
fnp-6316	239	6	of	of	ADP
fnp-6316	239	7	understanding	understand	VERB
fnp-6316	239	8	how	how	SCONJ
fnp-6316	239	9	changes	change	NOUN
fnp-6316	239	10	in	in	ADP
fnp-6316	239	11	the	the	DET
fnp-6316	239	12	vascular	vascular	ADJ
fnp-6316	239	13	network	network	NOUN
fnp-6316	239	14	and	and	CCONJ
fnp-6316	239	15	oxygen	oxygen	NOUN
fnp-6316	239	16	availability	availability	NOUN
fnp-6316	239	17	influence	influence	NOUN
fnp-6316	239	18	tumor	tumor	NOUN
fnp-6316	239	19	spread	spread	VERB
fnp-6316	239	20	,	,	PUNCT
fnp-6316	239	21	highhttps://doi.org/10.17879/freeneuropathology-2025-6316	highhttps://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	239	22	free	free	ADJ
fnp-6316	239	23	neuropathology	neuropathology	NOUN
fnp-6316	239	24	6:10	6:10	NUM
fnp-6316	239	25	(	(	PUNCT
fnp-6316	239	26	2025	2025	NUM
fnp-6316	239	27	)	)	PUNCT
fnp-6316	239	28	michel	michel	PROPN
fnp-6316	239	29	mittelbronn	mittelbronn	PROPN
fnp-6316	239	30	doi	doi	PROPN
fnp-6316	239	31	:	:	PUNCT
fnp-6316	239	32	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	239	33	page	page	NOUN
fnp-6316	239	34	16	16	NUM
fnp-6316	239	35	of	of	ADP
fnp-6316	239	36	19	19	NUM
fnp-6316	239	37	lighting	lighting	NOUN
fnp-6316	239	38	potential	potential	ADJ
fnp-6316	239	39	targets	target	NOUN
fnp-6316	239	40	for	for	ADP
fnp-6316	239	41	therapeutic	therapeutic	ADJ
fnp-6316	239	42	intervention	intervention	NOUN
fnp-6316	239	43	,	,	PUNCT
fnp-6316	239	44	especially	especially	ADV
fnp-6316	239	45	using	use	VERB
fnp-6316	239	46	prevention	prevention	NOUN
fnp-6316	239	47	strategies	strategy	NOUN
fnp-6316	239	48	inhibiting	inhibit	VERB
fnp-6316	239	49	brain	brain	NOUN
fnp-6316	239	50	metastasis	metastasis	NOUN
fnp-6316	239	51	seeding	seed	VERB
fnp-6316	239	52	by	by	ADP
fnp-6316	239	53	combined	combine	VERB
fnp-6316	239	54	inhibition	inhibition	NOUN
fnp-6316	239	55	of	of	ADP
fnp-6316	239	56	vegf	vegf	NOUN
fnp-6316	239	57	and	and	CCONJ
fnp-6316	239	58	ang-2	ang-2	NOUN
fnp-6316	239	59	.	.	PUNCT
fnp-6316	240	1	this	this	DET
fnp-6316	240	2	approach	approach	NOUN
fnp-6316	240	3	will	will	AUX
fnp-6316	240	4	change	change	VERB
fnp-6316	240	5	our	our	PRON
fnp-6316	240	6	therapeutic	therapeutic	ADJ
fnp-6316	240	7	view	view	NOUN
fnp-6316	240	8	as	as	SCONJ
fnp-6316	240	9	oncological	oncological	ADJ
fnp-6316	240	10	patients	patient	NOUN
fnp-6316	240	11	are	be	AUX
fnp-6316	240	12	usually	usually	ADV
fnp-6316	240	13	treated	treat	VERB
fnp-6316	240	14	when	when	SCONJ
fnp-6316	240	15	symptoms	symptom	NOUN
fnp-6316	240	16	or	or	CCONJ
fnp-6316	240	17	lesion	lesion	NOUN
fnp-6316	240	18	occur	occur	VERB
fnp-6316	240	19	.	.	PUNCT
fnp-6316	241	1	on	on	ADP
fnp-6316	241	2	the	the	DET
fnp-6316	241	3	primary	primary	ADJ
fnp-6316	241	4	malignant	malignant	ADJ
fnp-6316	241	5	brain	brain	NOUN
fnp-6316	241	6	tumor	tumor	NOUN
fnp-6316	241	7	side	side	NOUN
fnp-6316	241	8	,	,	PUNCT
fnp-6316	241	9	mathur	mathur	PROPN
fnp-6316	241	10	et	et	PROPN
fnp-6316	241	11	al	al	PROPN
fnp-6316	241	12	.	.	PROPN
fnp-6316	241	13	explored	explore	VERB
fnp-6316	241	14	glioblastoma	glioblastoma	NOUN
fnp-6316	241	15	's	's	PART
fnp-6316	241	16	evolution	evolution	NOUN
fnp-6316	241	17	and	and	CCONJ
fnp-6316	241	18	heterogeneity	heterogeneity	NOUN
fnp-6316	241	19	from	from	ADP
fnp-6316	241	20	a	a	DET
fnp-6316	241	21	whole	whole	ADJ
fnp-6316	241	22	tumor	tumor	NOUN
fnp-6316	241	23	perspective	perspective	NOUN
fnp-6316	242	1	[	[	X
fnp-6316	242	2	mathur	mathur	PROPN
fnp-6316	242	3	et	et	PROPN
fnp-6316	242	4	al	al	PROPN
fnp-6316	242	5	.	.	PROPN
fnp-6316	242	6	,	,	PUNCT
fnp-6316	242	7	2024	2024	NUM
fnp-6316	242	8	]	]	PUNCT
fnp-6316	242	9	.	.	PUNCT
fnp-6316	243	1	the	the	DET
fnp-6316	243	2	dynamic	dynamic	ADJ
fnp-6316	243	3	nature	nature	NOUN
fnp-6316	243	4	of	of	ADP
fnp-6316	243	5	glioblastoma	glioblastoma	NOUN
fnp-6316	243	6	,	,	PUNCT
fnp-6316	243	7	with	with	ADP
fnp-6316	243	8	its	its	PRON
fnp-6316	243	9	diverse	diverse	ADJ
fnp-6316	243	10	cellular	cellular	ADJ
fnp-6316	243	11	populations	population	NOUN
fnp-6316	243	12	and	and	CCONJ
fnp-6316	243	13	the	the	DET
fnp-6316	243	14	continuous	continuous	ADJ
fnp-6316	243	15	evolution	evolution	NOUN
fnp-6316	243	16	of	of	ADP
fnp-6316	243	17	its	its	PRON
fnp-6316	243	18	genetic	genetic	ADJ
fnp-6316	243	19	and	and	CCONJ
fnp-6316	243	20	epigenetic	epigenetic	ADJ
fnp-6316	243	21	landscape	landscape	NOUN
fnp-6316	243	22	,	,	PUNCT
fnp-6316	243	23	presents	present	VERB
fnp-6316	243	24	a	a	DET
fnp-6316	243	25	substantial	substantial	ADJ
fnp-6316	243	26	challenge	challenge	NOUN
fnp-6316	243	27	for	for	ADP
fnp-6316	243	28	both	both	DET
fnp-6316	243	29	diagnosis	diagnosis	NOUN
fnp-6316	243	30	and	and	CCONJ
fnp-6316	243	31	treatment	treatment	NOUN
fnp-6316	243	32	,	,	PUNCT
fnp-6316	243	33	however	however	ADV
fnp-6316	243	34	there	there	PRON
fnp-6316	243	35	is	be	VERB
fnp-6316	243	36	still	still	ADV
fnp-6316	243	37	a	a	DET
fnp-6316	243	38	considerable	considerable	ADJ
fnp-6316	243	39	debate	debate	NOUN
fnp-6316	243	40	about	about	ADP
fnp-6316	243	41	how	how	SCONJ
fnp-6316	243	42	hierarchical	hierarchical	ADJ
fnp-6316	243	43	or	or	CCONJ
fnp-6316	243	44	rather	rather	ADV
fnp-6316	243	45	reversible	reversible	ADJ
fnp-6316	243	46	such	such	DET
fnp-6316	243	47	an	an	DET
fnp-6316	243	48	evolution	evolution	NOUN
fnp-6316	243	49	is	be	AUX
fnp-6316	243	50	,	,	PUNCT
fnp-6316	243	51	the	the	DET
fnp-6316	243	52	latter	latter	ADJ
fnp-6316	243	53	more	more	ADV
fnp-6316	243	54	speaking	speak	VERB
fnp-6316	243	55	in	in	ADP
fnp-6316	243	56	favor	favor	NOUN
fnp-6316	243	57	of	of	ADP
fnp-6316	243	58	highly	highly	ADV
fnp-6316	243	59	dynamic	dynamic	ADJ
fnp-6316	243	60	,	,	PUNCT
fnp-6316	243	61	tumor	tumor	NOUN
fnp-6316	243	62	-	-	PUNCT
fnp-6316	243	63	intrinsic	intrinsic	ADJ
fnp-6316	243	64	plasticity	plasticity	NOUN
fnp-6316	243	65	[	[	X
fnp-6316	243	66	dirske	dirske	PROPN
fnp-6316	243	67	et	et	PROPN
fnp-6316	243	68	al	al	PROPN
fnp-6316	243	69	.	.	PROPN
fnp-6316	243	70	,	,	PUNCT
fnp-6316	243	71	2019	2019	NUM
fnp-6316	243	72	]	]	PUNCT
fnp-6316	243	73	.	.	PUNCT
fnp-6316	244	1	dna	dna	PROPN
fnp-6316	244	2	methylation	methylation	NOUN
fnp-6316	244	3	continues	continue	VERB
fnp-6316	244	4	to	to	PART
fnp-6316	244	5	emerge	emerge	VERB
fnp-6316	244	6	as	as	ADP
fnp-6316	244	7	a	a	DET
fnp-6316	244	8	crucial	crucial	ADJ
fnp-6316	244	9	mechanism	mechanism	NOUN
fnp-6316	244	10	in	in	ADP
fnp-6316	244	11	brain	brain	NOUN
fnp-6316	244	12	tumor	tumor	NOUN
fnp-6316	244	13	biology	biology	NOUN
fnp-6316	244	14	.	.	PUNCT
fnp-6316	245	1	drexler	drexler	PROPN
fnp-6316	245	2	et	et	PROPN
fnp-6316	245	3	al	al	PROPN
fnp-6316	245	4	.	.	PROPN
fnp-6316	245	5	and	and	CCONJ
fnp-6316	245	6	eckhardt	eckhardt	PROPN
fnp-6316	245	7	et	et	PROPN
fnp-6316	245	8	al	al	PROPN
fnp-6316	245	9	.	.	PROPN
fnp-6316	246	1	both	both	PRON
fnp-6316	246	2	highlight	highlight	VERB
fnp-6316	246	3	the	the	DET
fnp-6316	246	4	significance	significance	NOUN
fnp-6316	246	5	of	of	ADP
fnp-6316	246	6	dna	dna	PROPN
fnp-6316	246	7	methylation	methylation	NOUN
fnp-6316	246	8	profiles	profile	NOUN
fnp-6316	246	9	in	in	ADP
fnp-6316	246	10	glioblastoma	glioblastoma	NOUN
fnp-6316	246	11	[	[	X
fnp-6316	246	12	drexler	drexler	NOUN
fnp-6316	246	13	et	et	PROPN
fnp-6316	246	14	al	al	PROPN
fnp-6316	246	15	.	.	PROPN
fnp-6316	246	16	,	,	PUNCT
fnp-6316	246	17	2024	2024	NUM
fnp-6316	246	18	;	;	PUNCT
fnp-6316	246	19	eckhardt	eckhardt	PROPN
fnp-6316	246	20	et	et	PROPN
fnp-6316	246	21	al	al	PROPN
fnp-6316	246	22	.	.	PROPN
fnp-6316	246	23	,	,	PUNCT
fnp-6316	246	24	2024	2024	NUM
fnp-6316	246	25	]	]	PUNCT
fnp-6316	246	26	.	.	PUNCT
fnp-6316	247	1	drexler	drexler	PROPN
fnp-6316	247	2	et	et	PROPN
fnp-6316	247	3	al	al	PROPN
fnp-6316	247	4	.	.	PROPN
fnp-6316	247	5	demonstrate	demonstrate	VERB
fnp-6316	247	6	the	the	DET
fnp-6316	247	7	alterations	alteration	NOUN
fnp-6316	247	8	in	in	ADP
fnp-6316	247	9	dna	dna	PROPN
fnp-6316	247	10	methylation	methylation	NOUN
fnp-6316	247	11	in	in	ADP
fnp-6316	247	12	recurrent	recurrent	ADJ
fnp-6316	247	13	glioblastoma	glioblastoma	NOUN
fnp-6316	247	14	,	,	PUNCT
fnp-6316	247	15	providing	provide	VERB
fnp-6316	247	16	valuable	valuable	ADJ
fnp-6316	247	17	insights	insight	NOUN
fnp-6316	247	18	into	into	ADP
fnp-6316	247	19	the	the	DET
fnp-6316	247	20	epigenetic	epigenetic	ADJ
fnp-6316	247	21	shifts	shift	NOUN
fnp-6316	247	22	that	that	PRON
fnp-6316	247	23	occur	occur	VERB
fnp-6316	247	24	during	during	ADP
fnp-6316	247	25	disease	disease	NOUN
fnp-6316	247	26	progression	progression	NOUN
fnp-6316	247	27	,	,	PUNCT
fnp-6316	247	28	especially	especially	ADV
fnp-6316	247	29	that	that	DET
fnp-6316	247	30	methylation	methylation	NOUN
fnp-6316	247	31	classifier	classifier	NOUN
fnp-6316	247	32	subclasses	subclass	NOUN
fnp-6316	247	33	have	have	VERB
fnp-6316	247	34	to	to	PART
fnp-6316	247	35	be	be	AUX
fnp-6316	247	36	considered	consider	VERB
fnp-6316	247	37	with	with	ADP
fnp-6316	247	38	caution	caution	NOUN
fnp-6316	247	39	as	as	SCONJ
fnp-6316	247	40	they	they	PRON
fnp-6316	247	41	may	may	AUX
fnp-6316	247	42	considerably	considerably	ADV
fnp-6316	247	43	change	change	VERB
fnp-6316	247	44	over	over	ADP
fnp-6316	247	45	time	time	NOUN
fnp-6316	247	46	.	.	PUNCT
fnp-6316	248	1	meanwhile	meanwhile	ADV
fnp-6316	248	2	,	,	PUNCT
fnp-6316	248	3	eckhardt	eckhardt	PROPN
fnp-6316	248	4	et	et	PROPN
fnp-6316	248	5	al	al	PROPN
fnp-6316	248	6	.	.	PROPN
fnp-6316	249	1	present	present	PROPN
fnp-6316	249	2	global	global	ADJ
fnp-6316	249	3	dna	dna	PROPN
fnp-6316	249	4	methylation	methylation	NOUN
fnp-6316	249	5	as	as	ADP
fnp-6316	249	6	an	an	DET
fnp-6316	249	7	independent	independent	ADJ
fnp-6316	249	8	diagnostic	diagnostic	ADJ
fnp-6316	249	9	marker	marker	NOUN
fnp-6316	249	10	for	for	ADP
fnp-6316	249	11	idh	idh	NOUN
fnp-6316	249	12	-	-	PUNCT
fnp-6316	249	13	wildtype	wildtype	NOUN
fnp-6316	249	14	glioblastoma	glioblastoma	NOUN
fnp-6316	249	15	,	,	PUNCT
fnp-6316	249	16	offering	offer	VERB
fnp-6316	249	17	a	a	DET
fnp-6316	249	18	potential	potential	ADJ
fnp-6316	249	19	non	non	ADJ
fnp-6316	249	20	-	-	ADJ
fnp-6316	249	21	invasive	invasive	ADJ
fnp-6316	249	22	tool	tool	NOUN
fnp-6316	249	23	for	for	ADP
fnp-6316	249	24	early	early	ADJ
fnp-6316	249	25	diagnosis	diagnosis	NOUN
fnp-6316	249	26	and	and	CCONJ
fnp-6316	249	27	prognosis	prognosis	NOUN
fnp-6316	249	28	.	.	PUNCT
fnp-6316	250	1	of	of	ADP
fnp-6316	250	2	note	note	NOUN
fnp-6316	250	3	,	,	PUNCT
fnp-6316	250	4	they	they	PRON
fnp-6316	250	5	provide	provide	VERB
fnp-6316	250	6	an	an	DET
fnp-6316	250	7	easily	easily	ADV
fnp-6316	250	8	applicable	applicable	ADJ
fnp-6316	250	9	risk	risk	NOUN
fnp-6316	250	10	score	score	NOUN
fnp-6316	250	11	that	that	PRON
fnp-6316	250	12	can	can	AUX
fnp-6316	250	13	be	be	AUX
fnp-6316	250	14	integrated	integrate	VERB
fnp-6316	250	15	into	into	ADP
fnp-6316	250	16	routine	routine	ADJ
fnp-6316	250	17	diagnostic	diagnostic	ADJ
fnp-6316	250	18	procedures	procedure	NOUN
fnp-6316	250	19	,	,	PUNCT
fnp-6316	250	20	offering	offer	VERB
fnp-6316	250	21	significant	significant	ADJ
fnp-6316	250	22	prognostic	prognostic	ADJ
fnp-6316	250	23	value	value	NOUN
fnp-6316	250	24	by	by	ADP
fnp-6316	250	25	distinguishing	distinguish	VERB
fnp-6316	250	26	between	between	ADP
fnp-6316	250	27	a	a	DET
fnp-6316	250	28	high	high	ADJ
fnp-6316	250	29	-	-	PUNCT
fnp-6316	250	30	risk	risk	NOUN
fnp-6316	250	31	group	group	NOUN
fnp-6316	250	32	with	with	ADP
fnp-6316	250	33	a	a	DET
fnp-6316	250	34	median	median	ADJ
fnp-6316	250	35	survival	survival	NOUN
fnp-6316	250	36	of	of	ADP
fnp-6316	250	37	only	only	ADV
fnp-6316	250	38	8.3	8.3	NUM
fnp-6316	250	39	months	month	NOUN
fnp-6316	250	40	and	and	CCONJ
fnp-6316	250	41	a	a	DET
fnp-6316	250	42	lowrisk	lowrisk	NOUN
fnp-6316	250	43	group	group	NOUN
fnp-6316	250	44	with	with	ADP
fnp-6316	250	45	a	a	DET
fnp-6316	250	46	median	median	ADJ
fnp-6316	250	47	survival	survival	NOUN
fnp-6316	250	48	of	of	ADP
fnp-6316	250	49	39	39	NUM
fnp-6316	250	50	months	month	NOUN
fnp-6316	250	51	.	.	PUNCT
fnp-6316	251	1	these	these	DET
fnp-6316	251	2	findings	finding	NOUN
fnp-6316	251	3	underscore	underscore	VERB
fnp-6316	251	4	the	the	DET
fnp-6316	251	5	growing	grow	VERB
fnp-6316	251	6	interest	interest	NOUN
fnp-6316	251	7	in	in	ADP
fnp-6316	251	8	epigenetic	epigenetic	ADJ
fnp-6316	251	9	biomarkers	biomarker	NOUN
fnp-6316	251	10	for	for	ADP
fnp-6316	251	11	glioblastoma	glioblastoma	NOUN
fnp-6316	251	12	,	,	PUNCT
fnp-6316	251	13	which	which	PRON
fnp-6316	251	14	may	may	AUX
fnp-6316	251	15	ultimately	ultimately	ADV
fnp-6316	251	16	improve	improve	VERB
fnp-6316	251	17	diagnostic	diagnostic	ADJ
fnp-6316	251	18	accuracy	accuracy	NOUN
fnp-6316	251	19	and	and	CCONJ
fnp-6316	251	20	allow	allow	VERB
fnp-6316	251	21	for	for	ADP
fnp-6316	251	22	more	more	ADJ
fnp-6316	251	23	personalized	personalized	ADJ
fnp-6316	251	24	therapeutic	therapeutic	ADJ
fnp-6316	251	25	strategies	strategy	NOUN
fnp-6316	251	26	.	.	PUNCT
fnp-6316	252	1	in	in	ADP
fnp-6316	252	2	addition	addition	NOUN
fnp-6316	252	3	to	to	ADP
fnp-6316	252	4	dna	dna	PROPN
fnp-6316	252	5	methylation	methylation	NOUN
fnp-6316	252	6	,	,	PUNCT
fnp-6316	252	7	histopathological	histopathological	ADJ
fnp-6316	252	8	and	and	CCONJ
fnp-6316	252	9	molecular	molecular	ADJ
fnp-6316	252	10	features	feature	NOUN
fnp-6316	252	11	are	be	AUX
fnp-6316	252	12	increasingly	increasingly	ADV
fnp-6316	252	13	used	use	VERB
fnp-6316	252	14	to	to	PART
fnp-6316	252	15	predict	predict	VERB
fnp-6316	252	16	prognosis	prognosis	NOUN
fnp-6316	252	17	.	.	PUNCT
fnp-6316	253	1	kirishima	kirishima	PROPN
fnp-6316	253	2	et	et	PROPN
fnp-6316	253	3	al	al	PROPN
fnp-6316	253	4	.	.	PROPN
fnp-6316	253	5	demonstrate	demonstrate	VERB
fnp-6316	253	6	how	how	SCONJ
fnp-6316	253	7	histomorphological	histomorphological	ADJ
fnp-6316	253	8	features	feature	NOUN
fnp-6316	253	9	can	can	AUX
fnp-6316	253	10	provide	provide	VERB
fnp-6316	253	11	valuable	valuable	ADJ
fnp-6316	253	12	prognostic	prognostic	ADJ
fnp-6316	253	13	information	information	NOUN
fnp-6316	253	14	in	in	ADP
fnp-6316	253	15	glioblastoma	glioblastoma	NOUN
fnp-6316	253	16	,	,	PUNCT
fnp-6316	253	17	supporting	support	VERB
fnp-6316	253	18	the	the	DET
fnp-6316	253	19	role	role	NOUN
fnp-6316	253	20	of	of	ADP
fnp-6316	253	21	tissue	tissue	NOUN
fnp-6316	253	22	-	-	PUNCT
fnp-6316	253	23	based	base	VERB
fnp-6316	253	24	diagnostics	diagnostic	NOUN
fnp-6316	253	25	in	in	ADP
fnp-6316	253	26	clinical	clinical	ADJ
fnp-6316	253	27	settings	setting	NOUN
fnp-6316	253	28	[	[	X
fnp-6316	253	29	kirishima	kirishima	X
fnp-6316	253	30	et	et	PROPN
fnp-6316	253	31	al	al	PROPN
fnp-6316	253	32	.	.	PROPN
fnp-6316	253	33	,	,	PUNCT
fnp-6316	253	34	2024	2024	NUM
fnp-6316	253	35	]	]	PUNCT
fnp-6316	253	36	.	.	PUNCT
fnp-6316	254	1	a	a	DET
fnp-6316	254	2	considerable	considerable	ADJ
fnp-6316	254	3	limitation	limitation	NOUN
fnp-6316	254	4	of	of	ADP
fnp-6316	254	5	this	this	DET
fnp-6316	254	6	study	study	NOUN
fnp-6316	254	7	is	be	AUX
fnp-6316	254	8	that	that	SCONJ
fnp-6316	254	9	morphological	morphological	ADJ
fnp-6316	254	10	criteria	criterion	NOUN
fnp-6316	254	11	–	–	PUNCT
fnp-6316	254	12	despite	despite	SCONJ
fnp-6316	254	13	being	be	AUX
fnp-6316	254	14	carefully	carefully	ADV
fnp-6316	254	15	and	and	CCONJ
fnp-6316	254	16	precisely	precisely	ADV
fnp-6316	254	17	defined	define	VERB
fnp-6316	254	18	–	–	PUNCT
fnp-6316	254	19	are	be	AUX
fnp-6316	254	20	still	still	ADV
fnp-6316	254	21	subject	subject	ADJ
fnp-6316	254	22	to	to	ADP
fnp-6316	254	23	interpretation	interpretation	NOUN
fnp-6316	254	24	bias	bias	NOUN
fnp-6316	254	25	.	.	PUNCT
fnp-6316	255	1	this	this	PRON
fnp-6316	255	2	will	will	AUX
fnp-6316	255	3	need	need	VERB
fnp-6316	255	4	to	to	PART
fnp-6316	255	5	be	be	AUX
fnp-6316	255	6	considered	consider	VERB
fnp-6316	255	7	in	in	ADP
fnp-6316	255	8	the	the	DET
fnp-6316	255	9	future	future	NOUN
fnp-6316	255	10	when	when	SCONJ
fnp-6316	255	11	using	use	VERB
fnp-6316	255	12	artificial	artificial	ADJ
fnp-6316	255	13	intelligence	intelligence	NOUN
fnp-6316	255	14	algorithms	algorithm	NOUN
fnp-6316	255	15	applied	apply	VERB
fnp-6316	255	16	to	to	ADP
fnp-6316	255	17	digital	digital	ADJ
fnp-6316	255	18	images	image	NOUN
fnp-6316	255	19	,	,	PUNCT
fnp-6316	255	20	which	which	PRON
fnp-6316	255	21	are	be	AUX
fnp-6316	255	22	often	often	ADV
fnp-6316	255	23	annotated	annotate	VERB
fnp-6316	255	24	by	by	ADP
fnp-6316	255	25	human	human	NOUN
fnp-6316	255	26	(	(	PUNCT
fnp-6316	255	27	neuro)pathologists	neuro)pathologist	NOUN
fnp-6316	255	28	during	during	ADP
fnp-6316	255	29	the	the	DET
fnp-6316	255	30	training	training	NOUN
fnp-6316	255	31	phase	phase	NOUN
fnp-6316	255	32	.	.	PUNCT
fnp-6316	256	1	the	the	DET
fnp-6316	256	2	utilization	utilization	NOUN
fnp-6316	256	3	of	of	ADP
fnp-6316	256	4	cuttingedge	cuttingedge	ADJ
fnp-6316	256	5	technologies	technology	NOUN
fnp-6316	256	6	such	such	ADJ
fnp-6316	256	7	as	as	ADP
fnp-6316	256	8	confocal	confocal	ADJ
fnp-6316	256	9	laser	laser	NOUN
fnp-6316	256	10	microscopy	microscopy	NOUN
fnp-6316	256	11	in	in	ADP
fnp-6316	256	12	intraoperative	intraoperative	ADJ
fnp-6316	256	13	diagnostics	diagnostic	NOUN
fnp-6316	256	14	,	,	PUNCT
fnp-6316	256	15	as	as	SCONJ
fnp-6316	256	16	outlined	outline	VERB
fnp-6316	256	17	by	by	ADP
fnp-6316	256	18	wagner	wagner	PROPN
fnp-6316	256	19	et	et	PROPN
fnp-6316	256	20	al	al	PROPN
fnp-6316	256	21	.	.	PROPN
fnp-6316	256	22	,	,	PUNCT
fnp-6316	256	23	further	far	ADV
fnp-6316	256	24	enhances	enhance	VERB
fnp-6316	256	25	the	the	DET
fnp-6316	256	26	speed	speed	NOUN
fnp-6316	256	27	and	and	CCONJ
fnp-6316	256	28	hopefully	hopefully	ADV
fnp-6316	256	29	also	also	ADV
fnp-6316	256	30	the	the	DET
fnp-6316	256	31	precision	precision	NOUN
fnp-6316	256	32	in	in	ADP
fnp-6316	256	33	the	the	DET
fnp-6316	256	34	future	future	NOUN
fnp-6316	256	35	of	of	ADP
fnp-6316	256	36	tumor	tumor	NOUN
fnp-6316	256	37	identification	identification	NOUN
fnp-6316	256	38	and	and	CCONJ
fnp-6316	256	39	delineation	delineation	NOUN
fnp-6316	256	40	,	,	PUNCT
fnp-6316	256	41	offering	offer	VERB
fnp-6316	256	42	real	real	ADJ
fnp-6316	256	43	-	-	PUNCT
fnp-6316	256	44	time	time	NOUN
fnp-6316	256	45	guidance	guidance	NOUN
fnp-6316	256	46	during	during	ADP
fnp-6316	256	47	surgery	surgery	NOUN
fnp-6316	256	48	and	and	CCONJ
fnp-6316	256	49	improving	improve	VERB
fnp-6316	256	50	patient	patient	ADJ
fnp-6316	256	51	outcomes	outcome	NOUN
fnp-6316	256	52	[	[	X
fnp-6316	256	53	wagner	wagner	X
fnp-6316	256	54	et	et	PROPN
fnp-6316	256	55	al	al	PROPN
fnp-6316	256	56	.	.	PROPN
fnp-6316	256	57	,	,	PUNCT
fnp-6316	256	58	2024	2024	NUM
fnp-6316	256	59	]	]	PUNCT
fnp-6316	256	60	.	.	PUNCT
fnp-6316	257	1	this	this	DET
fnp-6316	257	2	technological	technological	ADJ
fnp-6316	257	3	advancement	advancement	NOUN
fnp-6316	257	4	,	,	PUNCT
fnp-6316	257	5	alongside	alongside	ADP
fnp-6316	257	6	the	the	DET
fnp-6316	257	7	development	development	NOUN
fnp-6316	257	8	of	of	ADP
fnp-6316	257	9	non	non	ADJ
fnp-6316	257	10	-	-	ADJ
fnp-6316	257	11	invasive	invasive	ADJ
fnp-6316	257	12	diagnostic	diagnostic	ADJ
fnp-6316	257	13	techniques	technique	NOUN
fnp-6316	257	14	like	like	ADP
fnp-6316	257	15	those	those	PRON
fnp-6316	257	16	reported	report	VERB
fnp-6316	257	17	by	by	ADP
fnp-6316	257	18	afflerbach	afflerbach	NOUN
fnp-6316	257	19	et	et	PROPN
fnp-6316	257	20	al	al	PROPN
fnp-6316	257	21	.	.	PROPN
fnp-6316	257	22	and	and	CCONJ
fnp-6316	257	23	hickman	hickman	PROPN
fnp-6316	257	24	et	et	PROPN
fnp-6316	257	25	al	al	PROPN
fnp-6316	257	26	.	.	PROPN
fnp-6316	257	27	,	,	PUNCT
fnp-6316	257	28	who	who	PRON
fnp-6316	257	29	used	use	VERB
fnp-6316	257	30	sequencing	sequencing	NOUN
fnp-6316	257	31	techniques	technique	NOUN
fnp-6316	257	32	of	of	ADP
fnp-6316	257	33	cell	cell	NOUN
fnp-6316	257	34	-	-	PUNCT
fnp-6316	257	35	free	free	ADJ
fnp-6316	257	36	dna	dna	NOUN
fnp-6316	257	37	from	from	ADP
fnp-6316	257	38	cerebrospinal	cerebrospinal	ADJ
fnp-6316	257	39	fluid	fluid	NOUN
fnp-6316	257	40	,	,	PUNCT
fnp-6316	257	41	marks	mark	VERB
fnp-6316	257	42	a	a	DET
fnp-6316	257	43	significant	significant	ADJ
fnp-6316	257	44	step	step	NOUN
fnp-6316	257	45	forward	forward	ADV
fnp-6316	257	46	in	in	ADP
fnp-6316	257	47	the	the	DET
fnp-6316	257	48	non	non	ADJ
fnp-6316	257	49	-	-	ADJ
fnp-6316	257	50	invasive	invasive	ADJ
fnp-6316	257	51	diagnosis	diagnosis	NOUN
fnp-6316	257	52	and	and	CCONJ
fnp-6316	257	53	monitoring	monitoring	NOUN
fnp-6316	257	54	of	of	ADP
fnp-6316	257	55	brain	brain	NOUN
fnp-6316	257	56	tumors	tumor	NOUN
fnp-6316	258	1	[	[	X
fnp-6316	258	2	afflerbach	afflerbach	NOUN
fnp-6316	258	3	et	et	PROPN
fnp-6316	258	4	al	al	PROPN
fnp-6316	258	5	.	.	PROPN
fnp-6316	258	6	,	,	PUNCT
fnp-6316	258	7	2024	2024	NUM
fnp-6316	258	8	;	;	PUNCT
fnp-6316	258	9	hickman	hickman	PROPN
fnp-6316	258	10	et	et	PROPN
fnp-6316	258	11	al	al	PROPN
fnp-6316	258	12	.	.	PROPN
fnp-6316	258	13	,	,	PUNCT
fnp-6316	258	14	2024	2024	NUM
fnp-6316	258	15	]	]	PUNCT
fnp-6316	258	16	.	.	PUNCT
fnp-6316	259	1	their	their	PRON
fnp-6316	259	2	work	work	NOUN
fnp-6316	259	3	presents	present	VERB
fnp-6316	259	4	exciting	exciting	ADJ
fnp-6316	259	5	prospects	prospect	NOUN
fnp-6316	259	6	for	for	ADP
fnp-6316	259	7	liquid	liquid	ADJ
fnp-6316	259	8	biopsy	biopsy	NOUN
fnp-6316	259	9	as	as	ADP
fnp-6316	259	10	a	a	DET
fnp-6316	259	11	means	means	NOUN
fnp-6316	259	12	to	to	PART
fnp-6316	259	13	detect	detect	VERB
fnp-6316	259	14	and	and	CCONJ
fnp-6316	259	15	track	track	VERB
fnp-6316	259	16	tumor	tumor	NOUN
fnp-6316	259	17	progression	progression	NOUN
fnp-6316	259	18	in	in	ADP
fnp-6316	259	19	real	real	ADJ
fnp-6316	259	20	-	-	PUNCT
fnp-6316	259	21	time	time	NOUN
fnp-6316	259	22	.	.	PUNCT
fnp-6316	260	1	immune	immune	ADJ
fnp-6316	260	2	cell	cell	NOUN
fnp-6316	260	3	dynamics	dynamic	NOUN
fnp-6316	260	4	are	be	AUX
fnp-6316	260	5	also	also	ADV
fnp-6316	260	6	a	a	DET
fnp-6316	260	7	focal	focal	ADJ
fnp-6316	260	8	point	point	NOUN
fnp-6316	260	9	of	of	ADP
fnp-6316	260	10	recent	recent	ADJ
fnp-6316	260	11	studies	study	NOUN
fnp-6316	260	12	.	.	PUNCT
fnp-6316	261	1	kirschenbaum	kirschenbaum	PROPN
fnp-6316	261	2	et	et	PROPN
fnp-6316	261	3	al	al	PROPN
fnp-6316	261	4	.	.	PROPN
fnp-6316	261	5	explore	explore	VERB
fnp-6316	261	6	the	the	DET
fnp-6316	261	7	time	time	NOUN
fnp-6316	261	8	-	-	PUNCT
fnp-6316	261	9	dependent	dependent	ADJ
fnp-6316	261	10	phenotyping	phenotyping	NOUN
fnp-6316	261	11	of	of	ADP
fnp-6316	261	12	immune	immune	ADJ
fnp-6316	261	13	cells	cell	NOUN
fnp-6316	261	14	in	in	ADP
fnp-6316	261	15	glioblastoma	glioblastoma	NOUN
fnp-6316	261	16	,	,	PUNCT
fnp-6316	261	17	providing	provide	VERB
fnp-6316	261	18	valuable	valuable	ADJ
fnp-6316	261	19	insights	insight	NOUN
fnp-6316	261	20	into	into	ADP
fnp-6316	261	21	the	the	DET
fnp-6316	261	22	temporal	temporal	ADJ
fnp-6316	261	23	changes	change	NOUN
fnp-6316	261	24	in	in	ADP
fnp-6316	261	25	immune	immune	ADJ
fnp-6316	261	26	cell	cell	NOUN
fnp-6316	261	27	populations	population	NOUN
fnp-6316	261	28	within	within	ADP
fnp-6316	261	29	the	the	DET
fnp-6316	261	30	tumor	tumor	NOUN
fnp-6316	261	31	microenvironment	microenvironment	NOUN
fnp-6316	261	32	.	.	PUNCT
fnp-6316	262	1	these	these	DET
fnp-6316	262	2	findings	finding	NOUN
fnp-6316	262	3	could	could	AUX
fnp-6316	262	4	have	have	VERB
fnp-6316	262	5	significant	significant	ADJ
fnp-6316	262	6	implications	implication	NOUN
fnp-6316	262	7	for	for	ADP
fnp-6316	262	8	immunotherapy	immunotherapy	NOUN
fnp-6316	262	9	,	,	PUNCT
fnp-6316	262	10	as	as	SCONJ
fnp-6316	262	11	the	the	DET
fnp-6316	262	12	ability	ability	NOUN
fnp-6316	262	13	to	to	PART
fnp-6316	262	14	track	track	VERB
fnp-6316	262	15	immune	immune	ADJ
fnp-6316	262	16	cell	cell	NOUN
fnp-6316	262	17	profiles	profile	NOUN
fnp-6316	262	18	over	over	ADP
fnp-6316	262	19	time	time	NOUN
fnp-6316	262	20	may	may	AUX
fnp-6316	262	21	inform	inform	VERB
fnp-6316	262	22	the	the	DET
fnp-6316	262	23	development	development	NOUN
fnp-6316	262	24	of	of	ADP
fnp-6316	262	25	more	more	ADV
fnp-6316	262	26	targeted	target	VERB
fnp-6316	262	27	immune	immune	NOUN
fnp-6316	262	28	-	-	PUNCT
fnp-6316	262	29	based	base	VERB
fnp-6316	262	30	therapies	therapy	NOUN
fnp-6316	263	1	[	[	X
fnp-6316	263	2	kirschenbaum	kirschenbaum	NOUN
fnp-6316	263	3	et	et	PROPN
fnp-6316	263	4	al	al	PROPN
fnp-6316	263	5	.	.	PROPN
fnp-6316	263	6	,	,	PUNCT
fnp-6316	263	7	2024	2024	NUM
fnp-6316	263	8	]	]	PUNCT
fnp-6316	263	9	.	.	PUNCT
fnp-6316	264	1	however	however	ADV
fnp-6316	264	2	,	,	PUNCT
fnp-6316	264	3	at	at	ADV
fnp-6316	264	4	least	least	ADJ
fnp-6316	264	5	as	as	ADV
fnp-6316	264	6	important	important	ADJ
fnp-6316	264	7	as	as	ADP
fnp-6316	264	8	the	the	DET
fnp-6316	264	9	scientific	scientific	ADJ
fnp-6316	264	10	findings	finding	NOUN
fnp-6316	264	11	of	of	ADP
fnp-6316	264	12	this	this	DET
fnp-6316	264	13	study	study	NOUN
fnp-6316	264	14	is	be	AUX
fnp-6316	264	15	the	the	DET
fnp-6316	264	16	technical	technical	ADJ
fnp-6316	264	17	development	development	NOUN
fnp-6316	264	18	of	of	ADP
fnp-6316	264	19	tracking	track	VERB
fnp-6316	264	20	immune	immune	ADJ
fnp-6316	264	21	cells	cell	NOUN
fnp-6316	264	22	through	through	ADP
fnp-6316	264	23	time	time	NOUN
fnp-6316	264	24	-	-	PUNCT
fnp-6316	264	25	dependent	dependent	ADJ
fnp-6316	264	26	transcriptomics	transcriptomic	NOUN
fnp-6316	264	27	using	use	VERB
fnp-6316	264	28	the	the	DET
fnp-6316	264	29	novel	novel	ADJ
fnp-6316	264	30	zman	zman	NOUN
fnp-6316	264	31	sequencing	sequencing	NOUN
fnp-6316	264	32	technique	technique	NOUN
fnp-6316	264	33	.	.	PUNCT
fnp-6316	265	1	at	at	ADP
fnp-6316	265	2	present	present	ADJ
fnp-6316	265	3	,	,	PUNCT
fnp-6316	265	4	this	this	DET
fnp-6316	265	5	approach	approach	NOUN
fnp-6316	265	6	is	be	AUX
fnp-6316	265	7	primarily	primarily	ADV
fnp-6316	265	8	suited	suit	VERB
fnp-6316	265	9	for	for	ADP
fnp-6316	265	10	cells	cell	NOUN
fnp-6316	265	11	infiltrating	infiltrate	VERB
fnp-6316	265	12	other	other	ADJ
fnp-6316	265	13	tissue	tissue	NOUN
fnp-6316	265	14	areas	area	NOUN
fnp-6316	265	15	,	,	PUNCT
fnp-6316	265	16	previously	previously	ADV
fnp-6316	265	17	labeled	label	VERB
fnp-6316	265	18	via	via	ADP
fnp-6316	265	19	the	the	DET
fnp-6316	265	20	bloodstream	bloodstream	NOUN
fnp-6316	265	21	.	.	PUNCT
fnp-6316	266	1	an	an	DET
fnp-6316	266	2	important	important	ADJ
fnp-6316	266	3	next	next	ADJ
fnp-6316	266	4	step	step	NOUN
fnp-6316	266	5	in	in	ADP
fnp-6316	266	6	the	the	DET
fnp-6316	266	7	development	development	NOUN
fnp-6316	266	8	of	of	ADP
fnp-6316	266	9	time	time	NOUN
fnp-6316	266	10	-	-	PUNCT
fnp-6316	266	11	dependent	dependent	ADJ
fnp-6316	266	12	transcriptomics	transcriptomic	NOUN
fnp-6316	266	13	would	would	AUX
fnp-6316	266	14	be	be	AUX
fnp-6316	266	15	expanding	expand	VERB
fnp-6316	266	16	its	its	PRON
fnp-6316	266	17	applicability	applicability	NOUN
fnp-6316	266	18	to	to	ADP
fnp-6316	266	19	cells	cell	NOUN
fnp-6316	266	20	that	that	PRON
fnp-6316	266	21	remain	remain	VERB
fnp-6316	266	22	within	within	ADP
fnp-6316	266	23	a	a	DET
fnp-6316	266	24	distinct	distinct	ADJ
fnp-6316	266	25	cellular	cellular	ADJ
fnp-6316	266	26	collective	collective	NOUN
fnp-6316	266	27	,	,	PUNCT
fnp-6316	266	28	such	such	ADJ
fnp-6316	266	29	as	as	ADP
fnp-6316	266	30	brain	brain	NOUN
fnp-6316	266	31	tumor	tumor	NOUN
fnp-6316	266	32	cells	cell	NOUN
fnp-6316	266	33	.	.	PUNCT
fnp-6316	267	1	this	this	DET
fnp-6316	267	2	ties	tie	NOUN
fnp-6316	267	3	in	in	ADP
fnp-6316	267	4	with	with	ADP
fnp-6316	267	5	the	the	DET
fnp-6316	267	6	work	work	NOUN
fnp-6316	267	7	of	of	ADP
fnp-6316	267	8	dobersalske	dobersalske	PROPN
fnp-6316	267	9	et	et	PROPN
fnp-6316	267	10	al	al	PROPN
fnp-6316	267	11	.	.	PROPN
fnp-6316	267	12	,	,	PUNCT
fnp-6316	267	13	who	who	PRON
fnp-6316	267	14	investigated	investigate	VERB
fnp-6316	267	15	the	the	DET
fnp-6316	267	16	role	role	NOUN
fnp-6316	267	17	of	of	ADP
fnp-6316	267	18	cranioencephalic	cranioencephalic	ADJ
fnp-6316	267	19	functional	functional	ADJ
fnp-6316	267	20	lymphoid	lymphoid	ADJ
fnp-6316	267	21	units	unit	NOUN
fnp-6316	267	22	in	in	ADP
fnp-6316	267	23	glioblastoma	glioblastoma	NOUN
fnp-6316	267	24	,	,	PUNCT
fnp-6316	267	25	expanding	expand	VERB
fnp-6316	267	26	our	our	PRON
fnp-6316	267	27	understanding	understanding	NOUN
fnp-6316	267	28	of	of	ADP
fnp-6316	267	29	how	how	SCONJ
fnp-6316	267	30	immune	immune	ADJ
fnp-6316	267	31	surveillance	surveillance	NOUN
fnp-6316	267	32	and	and	CCONJ
fnp-6316	267	33	local	local	ADJ
fnp-6316	267	34	immune	immune	ADJ
fnp-6316	267	35	responses	response	NOUN
fnp-6316	267	36	may	may	AUX
fnp-6316	267	37	influence	influence	VERB
fnp-6316	267	38	tumor	tumor	NOUN
fnp-6316	267	39	behavior	behavior	NOUN
fnp-6316	267	40	and	and	CCONJ
fnp-6316	267	41	response	response	NOUN
fnp-6316	267	42	to	to	ADP
fnp-6316	267	43	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	267	44	free	free	ADJ
fnp-6316	267	45	neuropathology	neuropathology	NOUN
fnp-6316	267	46	6:10	6:10	NUM
fnp-6316	267	47	(	(	PUNCT
fnp-6316	267	48	2025	2025	NUM
fnp-6316	267	49	)	)	PUNCT
fnp-6316	267	50	michel	michel	PROPN
fnp-6316	267	51	mittelbronn	mittelbronn	PROPN
fnp-6316	267	52	doi	doi	PROPN
fnp-6316	267	53	:	:	PUNCT
fnp-6316	267	54	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	267	55	page	page	NOUN
fnp-6316	267	56	17	17	NUM
fnp-6316	267	57	of	of	ADP
fnp-6316	267	58	19	19	NUM
fnp-6316	267	59	treatment	treatment	NOUN
fnp-6316	267	60	[	[	X
fnp-6316	267	61	dobersalske	dobersalske	PROPN
fnp-6316	267	62	et	et	PROPN
fnp-6316	267	63	al	al	PROPN
fnp-6316	267	64	.	.	PROPN
fnp-6316	267	65	,	,	PUNCT
fnp-6316	267	66	2024	2024	NUM
fnp-6316	267	67	]	]	PUNCT
fnp-6316	267	68	.	.	PUNCT
fnp-6316	268	1	to	to	PART
fnp-6316	268	2	further	far	ADV
fnp-6316	268	3	decipher	decipher	ADV
fnp-6316	268	4	the	the	DET
fnp-6316	268	5	temporal	temporal	ADJ
fnp-6316	268	6	dynamics	dynamic	NOUN
fnp-6316	268	7	of	of	ADP
fnp-6316	268	8	'	'	PUNCT
fnp-6316	268	9	glymphatic	glymphatic	ADJ
fnp-6316	268	10	'	'	PUNCT
fnp-6316	268	11	drainage	drainage	NOUN
fnp-6316	268	12	,	,	PUNCT
fnp-6316	268	13	zman	zman	NOUN
fnp-6316	268	14	sequencing	sequencing	NOUN
fnp-6316	268	15	could	could	AUX
fnp-6316	268	16	also	also	ADV
fnp-6316	268	17	be	be	AUX
fnp-6316	268	18	of	of	ADP
fnp-6316	268	19	interest	interest	NOUN
fnp-6316	268	20	in	in	ADP
fnp-6316	268	21	expanding	expand	VERB
fnp-6316	268	22	upon	upon	SCONJ
fnp-6316	268	23	the	the	DET
fnp-6316	268	24	findings	finding	NOUN
fnp-6316	268	25	of	of	ADP
fnp-6316	268	26	the	the	DET
fnp-6316	268	27	study	study	NOUN
fnp-6316	268	28	by	by	ADP
fnp-6316	268	29	dobersalske	dobersalske	PROPN
fnp-6316	268	30	et	et	PROPN
fnp-6316	268	31	al	al	PROPN
fnp-6316	268	32	.	.	PUNCT
fnp-6316	269	1	finally	finally	ADV
fnp-6316	269	2	,	,	PUNCT
fnp-6316	269	3	the	the	DET
fnp-6316	269	4	role	role	NOUN
fnp-6316	269	5	of	of	ADP
fnp-6316	269	6	post	post	ADJ
fnp-6316	269	7	-	-	ADJ
fnp-6316	269	8	translational	translational	ADJ
fnp-6316	269	9	modifications	modification	NOUN
fnp-6316	269	10	in	in	ADP
fnp-6316	269	11	tumorigenesis	tumorigenesis	NOUN
fnp-6316	269	12	is	be	AUX
fnp-6316	269	13	underscored	underscore	VERB
fnp-6316	269	14	by	by	ADP
fnp-6316	269	15	the	the	DET
fnp-6316	269	16	study	study	NOUN
fnp-6316	269	17	of	of	ADP
fnp-6316	269	18	chen	chen	PROPN
fnp-6316	269	19	et	et	PROPN
fnp-6316	269	20	al	al	PROPN
fnp-6316	269	21	.	.	PROPN
fnp-6316	269	22	,	,	PUNCT
fnp-6316	269	23	which	which	PRON
fnp-6316	269	24	examines	examine	VERB
fnp-6316	269	25	histone	histone	PROPN
fnp-6316	269	26	serotonylation	serotonylation	NOUN
fnp-6316	269	27	in	in	ADP
fnp-6316	269	28	ependymoma	ependymoma	PROPN
fnp-6316	269	29	tumorigenesis	tumorigenesis	NOUN
fnp-6316	270	1	[	[	X
fnp-6316	270	2	chen	chen	PROPN
fnp-6316	270	3	et	et	PROPN
fnp-6316	270	4	al	al	PROPN
fnp-6316	270	5	.	.	PROPN
fnp-6316	270	6	,	,	PUNCT
fnp-6316	270	7	2024	2024	NUM
fnp-6316	270	8	]	]	PUNCT
fnp-6316	270	9	.	.	PUNCT
fnp-6316	271	1	this	this	DET
fnp-6316	271	2	work	work	NOUN
fnp-6316	271	3	highlights	highlight	NOUN
fnp-6316	271	4	how	how	SCONJ
fnp-6316	271	5	serotonin	serotonin	NOUN
fnp-6316	271	6	-	-	PUNCT
fnp-6316	271	7	mediated	mediate	VERB
fnp-6316	271	8	alterations	alteration	NOUN
fnp-6316	271	9	in	in	ADP
fnp-6316	271	10	histone	histone	NOUN
fnp-6316	271	11	modifications	modification	NOUN
fnp-6316	271	12	can	can	AUX
fnp-6316	271	13	regulate	regulate	VERB
fnp-6316	271	14	tumor	tumor	NOUN
fnp-6316	271	15	growth	growth	NOUN
fnp-6316	271	16	and	and	CCONJ
fnp-6316	271	17	suggests	suggest	VERB
fnp-6316	271	18	that	that	SCONJ
fnp-6316	271	19	targeting	target	VERB
fnp-6316	271	20	epigenetic	epigenetic	ADJ
fnp-6316	271	21	regulators	regulator	NOUN
fnp-6316	271	22	may	may	AUX
fnp-6316	271	23	offer	offer	VERB
fnp-6316	271	24	a	a	DET
fnp-6316	271	25	novel	novel	ADJ
fnp-6316	271	26	therapeutic	therapeutic	ADJ
fnp-6316	271	27	avenue	avenue	NOUN
fnp-6316	271	28	for	for	ADP
fnp-6316	271	29	ependymomas	ependymomas	PROPN
fnp-6316	271	30	and	and	CCONJ
fnp-6316	271	31	other	other	ADJ
fnp-6316	271	32	brain	brain	NOUN
fnp-6316	271	33	tumors	tumor	NOUN
fnp-6316	271	34	.	.	PUNCT
fnp-6316	272	1	it	it	PRON
fnp-6316	272	2	remains	remain	VERB
fnp-6316	272	3	to	to	PART
fnp-6316	272	4	be	be	AUX
fnp-6316	272	5	determined	determine	VERB
fnp-6316	272	6	if	if	SCONJ
fnp-6316	272	7	serotonylation	serotonylation	NOUN
fnp-6316	272	8	will	will	AUX
fnp-6316	272	9	be	be	AUX
fnp-6316	272	10	a	a	DET
fnp-6316	272	11	reproducible	reproducible	ADJ
fnp-6316	272	12	,	,	PUNCT
fnp-6316	272	13	important	important	ADJ
fnp-6316	272	14	factor	factor	NOUN
fnp-6316	272	15	in	in	ADP
fnp-6316	272	16	brain	brain	NOUN
fnp-6316	272	17	tumor	tumor	NOUN
fnp-6316	272	18	progression	progression	NOUN
fnp-6316	272	19	in	in	ADP
fnp-6316	272	20	the	the	DET
fnp-6316	272	21	future	future	NOUN
fnp-6316	272	22	,	,	PUNCT
fnp-6316	272	23	however	however	ADV
fnp-6316	272	24	there	there	PRON
fnp-6316	272	25	is	be	VERB
fnp-6316	272	26	an	an	DET
fnp-6316	272	27	increasing	increase	VERB
fnp-6316	272	28	body	body	NOUN
fnp-6316	272	29	of	of	ADP
fnp-6316	272	30	evidence	evidence	NOUN
fnp-6316	272	31	that	that	SCONJ
fnp-6316	272	32	a	a	DET
fnp-6316	272	33	crosstalk	crosstalk	NOUN
fnp-6316	272	34	between	between	ADP
fnp-6316	272	35	neurons	neuron	NOUN
fnp-6316	272	36	and	and	CCONJ
fnp-6316	272	37	brain	brain	NOUN
fnp-6316	272	38	tumor	tumor	NOUN
fnp-6316	272	39	might	might	AUX
fnp-6316	272	40	be	be	AUX
fnp-6316	272	41	implicated	implicate	VERB
fnp-6316	272	42	[	[	PUNCT
fnp-6316	272	43	venkataramani	venkataramani	X
fnp-6316	272	44	et	et	PROPN
fnp-6316	272	45	al	al	PROPN
fnp-6316	272	46	.	.	PROPN
fnp-6316	272	47	,	,	PUNCT
fnp-6316	272	48	2025	2025	NUM
fnp-6316	272	49	]	]	PUNCT
fnp-6316	272	50	.	.	PUNCT
fnp-6316	273	1	together	together	ADV
fnp-6316	273	2	,	,	PUNCT
fnp-6316	273	3	these	these	DET
fnp-6316	273	4	studies	study	NOUN
fnp-6316	273	5	reflect	reflect	VERB
fnp-6316	273	6	a	a	DET
fnp-6316	273	7	shift	shift	NOUN
fnp-6316	273	8	toward	toward	ADP
fnp-6316	273	9	more	more	ADV
fnp-6316	273	10	comprehensive	comprehensive	ADJ
fnp-6316	273	11	,	,	PUNCT
fnp-6316	273	12	multifactorial	multifactorial	ADJ
fnp-6316	273	13	approaches	approach	NOUN
fnp-6316	273	14	to	to	ADP
fnp-6316	273	15	understanding	understanding	NOUN
fnp-6316	273	16	and	and	CCONJ
fnp-6316	273	17	treating	treat	VERB
fnp-6316	273	18	brain	brain	NOUN
fnp-6316	273	19	tumors	tumor	NOUN
fnp-6316	273	20	.	.	PUNCT
fnp-6316	274	1	in	in	ADP
fnp-6316	274	2	general	general	ADJ
fnp-6316	274	3	,	,	PUNCT
fnp-6316	274	4	there	there	PRON
fnp-6316	274	5	currently	currently	ADV
fnp-6316	274	6	seems	seem	VERB
fnp-6316	274	7	to	to	PART
fnp-6316	274	8	be	be	AUX
fnp-6316	274	9	a	a	DET
fnp-6316	274	10	disproportion	disproportion	NOUN
fnp-6316	274	11	between	between	ADP
fnp-6316	274	12	scientific	scientific	ADJ
fnp-6316	274	13	studies	study	NOUN
fnp-6316	274	14	focusing	focus	VERB
fnp-6316	274	15	on	on	ADP
fnp-6316	274	16	the	the	DET
fnp-6316	274	17	'	'	PUNCT
fnp-6316	274	18	bad	bad	ADJ
fnp-6316	274	19	guys	guy	NOUN
fnp-6316	274	20	'	'	PART
fnp-6316	274	21	–	–	PUNCT
fnp-6316	274	22	the	the	DET
fnp-6316	274	23	brain	brain	NOUN
fnp-6316	274	24	tumor	tumor	NOUN
fnp-6316	274	25	cells	cell	NOUN
fnp-6316	274	26	that	that	PRON
fnp-6316	274	27	proliferate	proliferate	VERB
fnp-6316	274	28	,	,	PUNCT
fnp-6316	274	29	migrate	migrate	VERB
fnp-6316	274	30	,	,	PUNCT
fnp-6316	274	31	and	and	CCONJ
fnp-6316	274	32	infiltrate	infiltrate	VERB
fnp-6316	274	33	–	–	PUNCT
fnp-6316	274	34	and	and	CCONJ
fnp-6316	274	35	the	the	DET
fnp-6316	274	36	large	large	ADJ
fnp-6316	274	37	number	number	NOUN
fnp-6316	274	38	of	of	ADP
fnp-6316	274	39	studies	study	NOUN
fnp-6316	274	40	examining	examine	VERB
fnp-6316	274	41	the	the	DET
fnp-6316	274	42	tumor	tumor	NOUN
fnp-6316	274	43	microenvironment	microenvironment	NOUN
fnp-6316	274	44	.	.	PUNCT
fnp-6316	275	1	while	while	SCONJ
fnp-6316	275	2	the	the	DET
fnp-6316	275	3	microenvironment	microenvironment	NOUN
fnp-6316	275	4	may	may	AUX
fnp-6316	275	5	contribute	contribute	VERB
fnp-6316	275	6	to	to	ADP
fnp-6316	275	7	tumor	tumor	NOUN
fnp-6316	275	8	progression	progression	NOUN
fnp-6316	275	9	,	,	PUNCT
fnp-6316	275	10	it	it	PRON
fnp-6316	275	11	lacks	lack	VERB
fnp-6316	275	12	the	the	DET
fnp-6316	275	13	malignant	malignant	ADJ
fnp-6316	275	14	oncogenic	oncogenic	ADJ
fnp-6316	275	15	driver	driver	NOUN
fnp-6316	275	16	mutations	mutation	NOUN
fnp-6316	275	17	.	.	PUNCT
fnp-6316	276	1	it	it	PRON
fnp-6316	276	2	may	may	AUX
fnp-6316	276	3	be	be	AUX
fnp-6316	276	4	easier	easy	ADJ
fnp-6316	276	5	to	to	PART
fnp-6316	276	6	study	study	VERB
fnp-6316	276	7	tumor	tumor	NOUN
fnp-6316	276	8	microenvironmental	microenvironmental	ADJ
fnp-6316	276	9	factors	factor	NOUN
fnp-6316	276	10	,	,	PUNCT
fnp-6316	276	11	possibly	possibly	ADV
fnp-6316	276	12	due	due	ADP
fnp-6316	276	13	to	to	ADP
fnp-6316	276	14	superior	superior	ADJ
fnp-6316	276	15	methodological	methodological	ADJ
fnp-6316	276	16	tools	tool	NOUN
fnp-6316	276	17	and	and	CCONJ
fnp-6316	276	18	simpler	simple	ADJ
fnp-6316	276	19	tracking	tracking	NOUN
fnp-6316	276	20	methods	method	NOUN
fnp-6316	276	21	,	,	PUNCT
fnp-6316	276	22	but	but	CCONJ
fnp-6316	276	23	it	it	PRON
fnp-6316	276	24	is	be	AUX
fnp-6316	276	25	crucial	crucial	ADJ
fnp-6316	276	26	not	not	PART
fnp-6316	276	27	to	to	PART
fnp-6316	276	28	lose	lose	VERB
fnp-6316	276	29	sight	sight	NOUN
fnp-6316	276	30	of	of	ADP
fnp-6316	276	31	tumor	tumor	NOUN
fnp-6316	276	32	cells	cell	NOUN
fnp-6316	276	33	as	as	ADP
fnp-6316	276	34	the	the	DET
fnp-6316	276	35	main	main	ADJ
fnp-6316	276	36	players	player	NOUN
fnp-6316	276	37	in	in	ADP
fnp-6316	276	38	future	future	ADJ
fnp-6316	276	39	research	research	NOUN
fnp-6316	276	40	.	.	PUNCT
fnp-6316	277	1	the	the	DET
fnp-6316	277	2	integration	integration	NOUN
fnp-6316	277	3	of	of	ADP
fnp-6316	277	4	molecular	molecular	ADJ
fnp-6316	277	5	and	and	CCONJ
fnp-6316	277	6	immune	immune	ADJ
fnp-6316	277	7	profiling	profiling	NOUN
fnp-6316	277	8	,	,	PUNCT
fnp-6316	277	9	advanced	advanced	ADJ
fnp-6316	277	10	imaging	imaging	NOUN
fnp-6316	277	11	technologies	technology	NOUN
fnp-6316	277	12	,	,	PUNCT
fnp-6316	277	13	and	and	CCONJ
fnp-6316	277	14	epigenetic	epigenetic	ADJ
fnp-6316	277	15	markers	marker	NOUN
fnp-6316	277	16	has	have	VERB
fnp-6316	277	17	the	the	DET
fnp-6316	277	18	potential	potential	NOUN
fnp-6316	277	19	to	to	PART
fnp-6316	277	20	revolutionize	revolutionize	VERB
fnp-6316	277	21	both	both	CCONJ
fnp-6316	277	22	the	the	DET
fnp-6316	277	23	diagnosis	diagnosis	NOUN
fnp-6316	277	24	and	and	CCONJ
fnp-6316	277	25	treatment	treatment	NOUN
fnp-6316	277	26	of	of	ADP
fnp-6316	277	27	primary	primary	ADJ
fnp-6316	277	28	and	and	CCONJ
fnp-6316	277	29	secondary	secondary	ADJ
fnp-6316	277	30	brain	brain	NOUN
fnp-6316	277	31	tumors	tumor	NOUN
fnp-6316	277	32	.	.	PUNCT
fnp-6316	278	1	as	as	SCONJ
fnp-6316	278	2	our	our	PRON
fnp-6316	278	3	understanding	understanding	NOUN
fnp-6316	278	4	of	of	ADP
fnp-6316	278	5	the	the	DET
fnp-6316	278	6	complex	complex	ADJ
fnp-6316	278	7	interplay	interplay	NOUN
fnp-6316	278	8	between	between	ADP
fnp-6316	278	9	tumor	tumor	NOUN
fnp-6316	278	10	biology	biology	NOUN
fnp-6316	278	11	,	,	PUNCT
fnp-6316	278	12	the	the	DET
fnp-6316	278	13	microenvironment	microenvironment	NOUN
fnp-6316	278	14	,	,	PUNCT
fnp-6316	278	15	and	and	CCONJ
fnp-6316	278	16	the	the	DET
fnp-6316	278	17	immune	immune	ADJ
fnp-6316	278	18	system	system	NOUN
fnp-6316	278	19	deepens	deepen	VERB
fnp-6316	278	20	,	,	PUNCT
fnp-6316	278	21	we	we	PRON
fnp-6316	278	22	can	can	AUX
fnp-6316	278	23	anticipate	anticipate	VERB
fnp-6316	278	24	more	more	ADV
fnp-6316	278	25	targeted	targeted	ADJ
fnp-6316	278	26	,	,	PUNCT
fnp-6316	278	27	individualized	individualized	ADJ
fnp-6316	278	28	therapies	therapy	NOUN
fnp-6316	278	29	that	that	PRON
fnp-6316	278	30	may	may	AUX
fnp-6316	278	31	significantly	significantly	ADV
fnp-6316	278	32	improve	improve	VERB
fnp-6316	278	33	patient	patient	ADJ
fnp-6316	278	34	outcomes	outcome	NOUN
fnp-6316	278	35	in	in	ADP
fnp-6316	278	36	the	the	DET
fnp-6316	278	37	future	future	NOUN
fnp-6316	278	38	.	.	PUNCT
fnp-6316	279	1	acknowledgements	acknowledgement	NOUN
fnp-6316	279	2	the	the	DET
fnp-6316	279	3	figures	figure	NOUN
fnp-6316	279	4	were	be	AUX
fnp-6316	279	5	prepared	prepare	VERB
fnp-6316	279	6	using	use	VERB
fnp-6316	279	7	https://biorender.com	https://biorender.com	X
fnp-6316	279	8	figure	figure	VERB
fnp-6316	279	9	creation	creation	NOUN
fnp-6316	279	10	tool	tool	NOUN
fnp-6316	279	11	.	.	PUNCT
fnp-6316	280	1	single	single	ADJ
fnp-6316	280	2	images	image	NOUN
fnp-6316	280	3	using	use	VERB
fnp-6316	280	4	for	for	ADP
fnp-6316	280	5	the	the	DET
fnp-6316	280	6	figures	figure	NOUN
fnp-6316	280	7	were	be	AUX
fnp-6316	280	8	freely	freely	ADV
fnp-6316	280	9	available	available	ADJ
fnp-6316	280	10	tagged	tag	VERB
fnp-6316	280	11	with	with	ADP
fnp-6316	280	12	creative	creative	ADJ
fnp-6316	280	13	common	common	ADJ
fnp-6316	280	14	license	license	NOUN
fnp-6316	280	15	.	.	PUNCT
fnp-6316	281	1	funding	funding	NOUN
fnp-6316	281	2	statement	statement	NOUN
fnp-6316	281	3	mm	mm	PROPN
fnp-6316	281	4	would	would	AUX
fnp-6316	281	5	like	like	VERB
fnp-6316	281	6	to	to	PART
fnp-6316	281	7	thank	thank	VERB
fnp-6316	281	8	the	the	DET
fnp-6316	281	9	luxembourg	luxembourg	PROPN
fnp-6316	281	10	national	national	PROPN
fnp-6316	281	11	research	research	PROPN
fnp-6316	281	12	fund	fund	PROPN
fnp-6316	281	13	(	(	PUNCT
fnp-6316	281	14	fnr	fnr	PROPN
fnp-6316	281	15	)	)	PUNCT
fnp-6316	281	16	for	for	ADP
fnp-6316	281	17	the	the	DET
fnp-6316	281	18	support	support	NOUN
fnp-6316	281	19	(	(	PUNCT
fnp-6316	281	20	fnr	fnr	PROPN
fnp-6316	281	21	pearl	pearl	NOUN
fnp-6316	281	22	p16	p16	PROPN
fnp-6316	281	23	/	/	SYM
fnp-6316	281	24	bm/11192868	bm/11192868	ADJ
fnp-6316	281	25	grant	grant	NOUN
fnp-6316	281	26	)	)	PUNCT
fnp-6316	281	27	.	.	PUNCT
fnp-6316	282	1	conflict	conflict	NOUN
fnp-6316	282	2	of	of	ADP
fnp-6316	282	3	interest	interest	NOUN
fnp-6316	282	4	the	the	DET
fnp-6316	282	5	author	author	NOUN
fnp-6316	282	6	does	do	AUX
fnp-6316	282	7	not	not	PART
fnp-6316	282	8	have	have	VERB
fnp-6316	282	9	any	any	DET
fnp-6316	282	10	conflict	conflict	NOUN
fnp-6316	282	11	of	of	ADP
fnp-6316	282	12	interest	interest	NOUN
fnp-6316	282	13	to	to	PART
fnp-6316	282	14	declare	declare	VERB
fnp-6316	282	15	.	.	PUNCT
fnp-6316	283	1	references	reference	NOUN
fnp-6316	283	2	1	1	NUM
fnp-6316	283	3	.	.	PUNCT
fnp-6316	283	4	afflerbach	afflerbach	PROPN
fnp-6316	283	5	ak	ak	PROPN
fnp-6316	283	6	,	,	PUNCT
fnp-6316	283	7	rohrandt	rohrandt	PROPN
fnp-6316	283	8	c	c	NOUN
fnp-6316	283	9	,	,	PUNCT
fnp-6316	283	10	brändl	brändl	NOUN
fnp-6316	283	11	b	b	NOUN
fnp-6316	283	12	,	,	PUNCT
fnp-6316	283	13	sönksen	sönksen	NOUN
fnp-6316	283	14	m	m	PROPN
fnp-6316	283	15	,	,	PUNCT
fnp-6316	283	16	hench	hench	PROPN
fnp-6316	283	17	j	j	PROPN
fnp-6316	283	18	,	,	PUNCT
fnp-6316	283	19	frank	frank	PROPN
fnp-6316	283	20	s	s	PROPN
fnp-6316	283	21	,	,	PUNCT
fnp-6316	283	22	börnigen	börnigen	PROPN
fnp-6316	283	23	d	d	PROPN
fnp-6316	283	24	,	,	PUNCT
fnp-6316	283	25	alawi	alawi	PROPN
fnp-6316	283	26	m	m	PROPN
fnp-6316	283	27	,	,	PUNCT
fnp-6316	283	28	mynarek	mynarek	PROPN
fnp-6316	283	29	m	m	PROPN
fnp-6316	283	30	,	,	PUNCT
fnp-6316	283	31	winkler	winkler	PROPN
fnp-6316	283	32	b	b	PROPN
fnp-6316	283	33	,	,	PUNCT
fnp-6316	283	34	ricklefs	ricklefs	PROPN
fnp-6316	283	35	f	f	NUM
fnp-6316	283	36	,	,	PUNCT
fnp-6316	283	37	synowitz	synowitz	PROPN
fnp-6316	283	38	m	m	PROPN
fnp-6316	283	39	,	,	PUNCT
fnp-6316	283	40	dührsen	dührsen	ADJ
fnp-6316	283	41	l	l	PROPN
fnp-6316	283	42	,	,	PUNCT
fnp-6316	283	43	rutkowski	rutkowski	PROPN
fnp-6316	283	44	s	s	PROPN
fnp-6316	283	45	,	,	PUNCT
fnp-6316	283	46	wefers	wefers	PROPN
fnp-6316	283	47	ak	ak	PROPN
fnp-6316	283	48	,	,	PUNCT
fnp-6316	283	49	müller	müller	PROPN
fnp-6316	283	50	fj	fj	PROPN
fnp-6316	283	51	,	,	PUNCT
fnp-6316	283	52	schoof	schoof	PROPN
fnp-6316	283	53	m	m	PROPN
fnp-6316	283	54	,	,	PUNCT
fnp-6316	283	55	schüller	schüll	ADJ
fnp-6316	283	56	u.	u.	NOUN
fnp-6316	283	57	classification	classification	NOUN
fnp-6316	283	58	of	of	ADP
fnp-6316	283	59	brain	brain	NOUN
fnp-6316	283	60	tumors	tumor	NOUN
fnp-6316	283	61	by	by	ADP
fnp-6316	283	62	nanopore	nanopore	ADJ
fnp-6316	283	63	sequencing	sequencing	NOUN
fnp-6316	283	64	of	of	ADP
fnp-6316	283	65	cell	cell	NOUN
fnp-6316	283	66	-	-	PUNCT
fnp-6316	283	67	free	free	ADJ
fnp-6316	283	68	dna	dna	NOUN
fnp-6316	283	69	from	from	ADP
fnp-6316	283	70	cerebrospinal	cerebrospinal	ADJ
fnp-6316	283	71	fluid	fluid	NOUN
fnp-6316	283	72	.	.	PUNCT
fnp-6316	284	1	clin	clin	PROPN
fnp-6316	284	2	chem	chem	PROPN
fnp-6316	284	3	.	.	PUNCT
fnp-6316	285	1	2024	2024	NUM
fnp-6316	285	2	jan	jan	NOUN
fnp-6316	285	3	4;70(1):250	4;70(1):250	NUM
fnp-6316	285	4	-	-	SYM
fnp-6316	285	5	260	260	NUM
fnp-6316	285	6	.	.	PUNCT
fnp-6316	285	7	https://doi.org/10.1093/clinchem/hvad115	https://doi.org/10.1093/clinchem/hvad115	PROPN
fnp-6316	286	1	2	2	NUM
fnp-6316	286	2	.	.	X
fnp-6316	286	3	albuck	albuck	PROPN
fnp-6316	286	4	al	al	PROPN
fnp-6316	286	5	,	,	PUNCT
fnp-6316	286	6	becnel	becnel	PROPN
fnp-6316	286	7	cm	cm	PROPN
fnp-6316	286	8	,	,	PUNCT
fnp-6316	286	9	sirna	sirna	PROPN
fnp-6316	286	10	dj	dj	PROPN
fnp-6316	286	11	,	,	PUNCT
fnp-6316	286	12	turner	turner	PROPN
fnp-6316	286	13	j.	j.	PROPN
fnp-6316	286	14	j	j	PROPN
fnp-6316	286	15	surg	surg	PROPN
fnp-6316	286	16	res	re	NOUN
fnp-6316	286	17	.	.	PUNCT
fnp-6316	287	1	2024	2024	NUM
fnp-6316	287	2	oct	oct	NOUN
fnp-6316	287	3	;	;	PUNCT
fnp-6316	287	4	302:324	302:324	PROPN
fnp-6316	287	5	-	-	PUNCT
fnp-6316	287	6	328	328	NUM
fnp-6316	287	7	.	.	PUNCT
fnp-6316	288	1	https://doi.org/10.1016/j.jss.2024.07.021	https://doi.org/10.1016/j.jss.2024.07.021	NOUN
fnp-6316	288	2	3	3	NUM
fnp-6316	288	3	.	.	PUNCT
fnp-6316	289	1	allen	allen	PROPN
fnp-6316	289	2	f	f	PROPN
fnp-6316	289	3	,	,	PUNCT
fnp-6316	289	4	bobanga	bobanga	PROPN
fnp-6316	289	5	i	i	PROPN
fnp-6316	289	6	d	d	PROPN
fnp-6316	289	7	,	,	PUNCT
fnp-6316	289	8	rauhe	rauhe	PROPN
fnp-6316	289	9	p	p	NOUN
fnp-6316	289	10	,	,	PUNCT
fnp-6316	289	11	barkauskas	barkauskas	NOUN
fnp-6316	289	12	d	d	NOUN
fnp-6316	289	13	,	,	PUNCT
fnp-6316	289	14	teich	teich	ADJ
fnp-6316	289	15	n	n	CCONJ
fnp-6316	289	16	,	,	PUNCT
fnp-6316	289	17	tong	tong	PROPN
fnp-6316	289	18	c	c	PROPN
fnp-6316	289	19	,	,	PUNCT
fnp-6316	289	20	myers	myers	PROPN
fnp-6316	289	21	j	j	PROPN
fnp-6316	289	22	,	,	PUNCT
fnp-6316	289	23	huang	huang	PROPN
fnp-6316	289	24	ay	ay	PROPN
fnp-6316	289	25	.	.	PUNCT
fnp-6316	290	1	ccl3	ccl3	PROPN
fnp-6316	290	2	augments	augment	VERB
fnp-6316	290	3	tumor	tumor	NOUN
fnp-6316	290	4	rejection	rejection	NOUN
fnp-6316	290	5	and	and	CCONJ
fnp-6316	290	6	enhances	enhance	VERB
fnp-6316	290	7	cd8	cd8	PROPN
fnp-6316	290	8	+	+	PROPN
fnp-6316	290	9	t	t	PROPN
fnp-6316	290	10	cell	cell	NOUN
fnp-6316	290	11	infiltration	infiltration	NOUN
fnp-6316	290	12	through	through	ADP
fnp-6316	290	13	nk	nk	PROPN
fnp-6316	290	14	and	and	CCONJ
fnp-6316	290	15	cd103	cd103	PROPN
fnp-6316	290	16	+	+	ADP
fnp-6316	290	17	dendritic	dendritic	ADJ
fnp-6316	290	18	cell	cell	NOUN
fnp-6316	290	19	recruitment	recruitment	NOUN
fnp-6316	290	20	via	via	ADP
fnp-6316	290	21	ifnγ	ifnγ	NOUN
fnp-6316	290	22	.	.	PUNCT
fnp-6316	291	1	oncoimmunology	oncoimmunology	NOUN
fnp-6316	291	2	.	.	PUNCT
fnp-6316	292	1	2017	2017	NUM
fnp-6316	292	2	nov	nov	NOUN
fnp-6316	292	3	20;7(3):e1393598	20;7(3):e1393598	NUM
fnp-6316	292	4	.	.	PUNCT
fnp-6316	293	1	https://doi.org/10.1080/2162402x.2017.1393598	https://doi.org/10.1080/2162402x.2017.1393598	PROPN
fnp-6316	293	2	4	4	NUM
fnp-6316	293	3	.	.	PUNCT
fnp-6316	294	1	avraham	avraham	PROPN
fnp-6316	294	2	hk	hk	PROPN
fnp-6316	294	3	,	,	PUNCT
fnp-6316	294	4	jiang	jiang	PROPN
fnp-6316	294	5	s	s	PROPN
fnp-6316	294	6	,	,	PUNCT
fnp-6316	294	7	fu	fu	PROPN
fnp-6316	294	8	y	y	PROPN
fnp-6316	294	9	,	,	PUNCT
fnp-6316	294	10	nakshatri	nakshatri	ADJ
fnp-6316	294	11	h	h	PROPN
fnp-6316	294	12	,	,	PUNCT
fnp-6316	294	13	ovadia	ovadia	PROPN
fnp-6316	294	14	h	h	NOUN
fnp-6316	294	15	,	,	PUNCT
fnp-6316	294	16	avraham	avraham	PROPN
fnp-6316	294	17	s.	s.	PROPN
fnp-6316	294	18	angiopoietin-2	angiopoietin-2	PROPN
fnp-6316	294	19	mediates	mediate	NOUN
fnp-6316	294	20	blood	blood	NOUN
fnp-6316	294	21	-	-	PUNCT
fnp-6316	294	22	brain	brain	NOUN
fnp-6316	294	23	barrier	barrier	NOUN
fnp-6316	294	24	impairment	impairment	NOUN
fnp-6316	294	25	and	and	CCONJ
fnp-6316	294	26	colonization	colonization	NOUN
fnp-6316	294	27	of	of	ADP
fnp-6316	294	28	triple	triple	ADJ
fnp-6316	294	29	-	-	PUNCT
fnp-6316	294	30	negative	negative	ADJ
fnp-6316	294	31	breast	breast	NOUN
fnp-6316	294	32	cancer	cancer	NOUN
fnp-6316	294	33	cells	cell	NOUN
fnp-6316	294	34	in	in	ADP
fnp-6316	294	35	brain	brain	NOUN
fnp-6316	294	36	.	.	PUNCT
fnp-6316	295	1	j	j	PROPN
fnp-6316	295	2	pathol	pathol	PROPN
fnp-6316	295	3	.	.	PUNCT
fnp-6316	296	1	2014	2014	NUM
fnp-6316	296	2	feb	feb	NOUN
fnp-6316	296	3	;	;	PUNCT
fnp-6316	296	4	232(3):369	232(3):369	NUM
fnp-6316	296	5	-	-	SYM
fnp-6316	296	6	81	81	NUM
fnp-6316	296	7	.	.	PUNCT
fnp-6316	297	1	https://doi.org/10.1002/path.4304	https://doi.org/10.1002/path.4304	PROPN
fnp-6316	297	2	5	5	NUM
fnp-6316	297	3	.	.	PUNCT
fnp-6316	298	1	bohn	bohn	PROPN
fnp-6316	298	2	ka	ka	PROPN
fnp-6316	298	3	,	,	PUNCT
fnp-6316	298	4	adkins	adkins	PROPN
fnp-6316	298	5	ce	ce	PROPN
fnp-6316	298	6	,	,	PUNCT
fnp-6316	298	7	nounou	nounou	PROPN
fnp-6316	298	8	mi	mi	PROPN
fnp-6316	298	9	,	,	PUNCT
fnp-6316	298	10	lockman	lockman	PROPN
fnp-6316	298	11	pr	pr	NOUN
fnp-6316	298	12	.	.	PUNCT
fnp-6316	299	1	inhibition	inhibition	NOUN
fnp-6316	299	2	of	of	ADP
fnp-6316	299	3	vegf	vegf	PROPN
fnp-6316	299	4	and	and	CCONJ
fnp-6316	299	5	angiopoietin-2	angiopoietin-2	NUM
fnp-6316	299	6	to	to	PART
fnp-6316	299	7	reduce	reduce	VERB
fnp-6316	299	8	brain	brain	NOUN
fnp-6316	299	9	metastases	metastasis	NOUN
fnp-6316	299	10	of	of	ADP
fnp-6316	299	11	breast	breast	NOUN
fnp-6316	299	12	cancer	cancer	NOUN
fnp-6316	299	13	burden	burden	NOUN
fnp-6316	299	14	.	.	PUNCT
fnp-6316	300	1	front	front	ADJ
fnp-6316	300	2	pharmacol	pharmacol	PROPN
fnp-6316	300	3	.	.	PUNCT
fnp-6316	301	1	2017	2017	NUM
fnp-6316	301	2	apr	apr	NOUN
fnp-6316	301	3	11;8:193	11;8:193	NUM
fnp-6316	301	4	.	.	PUNCT
fnp-6316	302	1	https://doi.org/10.3389/fphar.2017.00193	https://doi.org/10.3389/fphar.2017.00193	PROPN
fnp-6316	302	2	6	6	NUM
fnp-6316	302	3	.	.	NOUN
fnp-6316	302	4	brodbelt	brodbelt	PROPN
fnp-6316	302	5	a	a	PRON
fnp-6316	302	6	,	,	PUNCT
fnp-6316	302	7	greenberg	greenberg	PROPN
fnp-6316	302	8	d	d	PROPN
fnp-6316	302	9	,	,	PUNCT
fnp-6316	302	10	winters	winters	PROPN
fnp-6316	302	11	t	t	PROPN
fnp-6316	302	12	,	,	PUNCT
fnp-6316	302	13	williams	williams	PROPN
fnp-6316	302	14	m	m	PROPN
fnp-6316	302	15	,	,	PUNCT
fnp-6316	302	16	vernon	vernon	PROPN
fnp-6316	302	17	s	s	PROPN
fnp-6316	302	18	,	,	PUNCT
fnp-6316	302	19	collins	collins	PROPN
fnp-6316	302	20	vp	vp	PROPN
fnp-6316	302	21	;	;	PUNCT
fnp-6316	302	22	(	(	PUNCT
fnp-6316	302	23	uk	uk	PROPN
fnp-6316	302	24	)	)	PUNCT
fnp-6316	302	25	national	national	ADJ
fnp-6316	302	26	cancer	cancer	NOUN
fnp-6316	302	27	information	information	NOUN
fnp-6316	302	28	network	network	NOUN
fnp-6316	302	29	brain	brain	VERB
fnp-6316	302	30	tumour	tumour	NOUN
fnp-6316	302	31	group	group	NOUN
fnp-6316	302	32	.	.	PUNCT
fnp-6316	303	1	eur	eur	PROPN
fnp-6316	303	2	j	j	PROPN
fnp-6316	303	3	cancer	cancer	NOUN
fnp-6316	303	4	.	.	PUNCT
fnp-6316	304	1	2015	2015	NUM
fnp-6316	304	2	mar;51(4):533	mar;51(4):533	NOUN
fnp-6316	304	3	-	-	PUNCT
fnp-6316	304	4	542	542	NUM
fnp-6316	304	5	.	.	PUNCT
fnp-6316	305	1	https://doi.org/10.1016/j.ejca.2014.12.014	https://doi.org/10.1016/j.ejca.2014.12.014	PROPN
fnp-6316	305	2	7	7	NUM
fnp-6316	305	3	.	.	NUM
fnp-6316	305	4	capper	capper	PROPN
fnp-6316	305	5	d	d	PROPN
fnp-6316	305	6	,	,	PUNCT
fnp-6316	305	7	jones	jones	PROPN
fnp-6316	305	8	dtw	dtw	PROPN
fnp-6316	305	9	,	,	PUNCT
fnp-6316	305	10	sill	sill	NOUN
fnp-6316	305	11	m	m	PROPN
fnp-6316	305	12	,	,	PUNCT
fnp-6316	305	13	hovestadt	hovestadt	ADJ
fnp-6316	305	14	v	v	NOUN
fnp-6316	305	15	,	,	PUNCT
fnp-6316	305	16	schrimpf	schrimpf	NOUN
fnp-6316	305	17	d	d	PROPN
fnp-6316	305	18	,	,	PUNCT
fnp-6316	305	19	sturm	sturm	PROPN
fnp-6316	305	20	d	d	PROPN
fnp-6316	305	21	,	,	PUNCT
fnp-6316	305	22	koelsche	koelsche	PROPN
fnp-6316	305	23	c	c	PROPN
fnp-6316	305	24	,	,	PUNCT
fnp-6316	305	25	sahm	sahm	PROPN
fnp-6316	305	26	f	f	PROPN
fnp-6316	305	27	,	,	PUNCT
fnp-6316	305	28	chavez	chavez	PROPN
fnp-6316	305	29	l	l	PROPN
fnp-6316	305	30	,	,	PUNCT
fnp-6316	305	31	reuss	reuss	PROPN
fnp-6316	305	32	de	de	PROPN
fnp-6316	305	33	,	,	PUNCT
fnp-6316	305	34	kratz	kratz	PROPN
fnp-6316	305	35	a	a	PROPN
fnp-6316	305	36	,	,	PUNCT
fnp-6316	305	37	wefers	wefers	PROPN
fnp-6316	305	38	ak	ak	PROPN
fnp-6316	305	39	,	,	PUNCT
fnp-6316	305	40	huang	huang	PROPN
fnp-6316	305	41	k	k	PROPN
fnp-6316	305	42	,	,	PUNCT
fnp-6316	305	43	pajtler	pajtler	ADJ
fnp-6316	305	44	kw	kw	PROPN
fnp-6316	305	45	,	,	PUNCT
fnp-6316	305	46	schweizer	schweizer	PROPN
fnp-6316	305	47	l	l	PROPN
fnp-6316	305	48	,	,	PUNCT
fnp-6316	305	49	stichel	stichel	PROPN
fnp-6316	305	50	d	d	PROPN
fnp-6316	305	51	,	,	PUNCT
fnp-6316	305	52	olar	olar	ADJ
fnp-6316	305	53	a	a	PRON
fnp-6316	305	54	,	,	PUNCT
fnp-6316	305	55	engel	engel	PROPN
fnp-6316	305	56	nw	nw	PROPN
fnp-6316	305	57	,	,	PUNCT
fnp-6316	305	58	lindenberg	lindenberg	PROPN
fnp-6316	305	59	k	k	PROPN
fnp-6316	305	60	,	,	PUNCT
fnp-6316	305	61	harter	harter	PROPN
fnp-6316	305	62	pn	pn	PROPN
fnp-6316	305	63	,	,	PUNCT
fnp-6316	305	64	braczynski	braczynski	PROPN
fnp-6316	305	65	ak	ak	PROPN
fnp-6316	305	66	,	,	PUNCT
fnp-6316	305	67	plate	plate	NOUN
fnp-6316	305	68	kh	kh	PROPN
fnp-6316	305	69	,	,	PUNCT
fnp-6316	305	70	dohmen	dohmen	PROPN
fnp-6316	305	71	h	h	NOUN
fnp-6316	305	72	,	,	PUNCT
fnp-6316	305	73	garvalov	garvalov	VERB
fnp-6316	305	74	bk	bk	PROPN
fnp-6316	305	75	,	,	PUNCT
fnp-6316	305	76	coras	coras	PROPN
fnp-6316	305	77	r	r	PROPN
fnp-6316	305	78	,	,	PUNCT
fnp-6316	305	79	hölsken	hölsken	VERB
fnp-6316	305	80	a	a	PRON
fnp-6316	305	81	,	,	PUNCT
fnp-6316	305	82	hewer	hewer	PROPN
fnp-6316	305	83	e	e	NOUN
fnp-6316	305	84	,	,	PUNCT
fnp-6316	305	85	bewerunge	bewerunge	NOUN
fnp-6316	305	86	-	-	PUNCT
fnp-6316	305	87	hudler	hudler	PROPN
fnp-6316	305	88	m	m	PROPN
fnp-6316	305	89	,	,	PUNCT
fnp-6316	305	90	schick	schick	PROPN
fnp-6316	305	91	m	m	PROPN
fnp-6316	305	92	,	,	PUNCT
fnp-6316	305	93	fischer	fischer	PROPN
fnp-6316	305	94	r	r	PROPN
fnp-6316	305	95	,	,	PUNCT
fnp-6316	305	96	beschorner	beschorner	NOUN
fnp-6316	305	97	r	r	NOUN
fnp-6316	305	98	,	,	PUNCT
fnp-6316	305	99	schittenhelm	schittenhelm	PROPN
fnp-6316	305	100	j	j	PROPN
fnp-6316	305	101	,	,	PUNCT
fnp-6316	305	102	staszewski	staszewski	PROPN
fnp-6316	305	103	o	o	PROPN
fnp-6316	305	104	,	,	PUNCT
fnp-6316	305	105	wani	wani	PROPN
fnp-6316	305	106	k	k	PROPN
fnp-6316	305	107	,	,	PUNCT
fnp-6316	305	108	varlet	varlet	VERB
fnp-6316	305	109	p	p	PRON
fnp-6316	305	110	,	,	PUNCT
fnp-6316	305	111	pages	page	NOUN
fnp-6316	305	112	m	m	PRON
fnp-6316	305	113	,	,	PUNCT
fnp-6316	305	114	temming	temme	VERB
fnp-6316	305	115	p	p	PRON
fnp-6316	305	116	,	,	PUNCT
fnp-6316	306	1	lohmann	lohmann	PROPN
fnp-6316	306	2	d	d	PROPN
fnp-6316	306	3	,	,	PUNCT
fnp-6316	306	4	selt	selt	PROPN
fnp-6316	306	5	f	f	PROPN
fnp-6316	306	6	,	,	PUNCT
fnp-6316	306	7	witt	witt	PROPN
fnp-6316	306	8	h	h	PROPN
fnp-6316	306	9	,	,	PUNCT
fnp-6316	306	10	milde	milde	PROPN
fnp-6316	306	11	t	t	PROPN
fnp-6316	306	12	,	,	PUNCT
fnp-6316	306	13	witt	witt	PROPN
fnp-6316	306	14	o	o	NOUN
fnp-6316	306	15	,	,	PUNCT
fnp-6316	306	16	aronica	aronica	PROPN
fnp-6316	306	17	e	e	PROPN
fnp-6316	306	18	,	,	PUNCT
fnp-6316	306	19	giangaspero	giangaspero	PROPN
fnp-6316	306	20	f	f	PROPN
fnp-6316	306	21	,	,	PUNCT
fnp-6316	306	22	rushing	rush	VERB
fnp-6316	306	23	e	e	NOUN
fnp-6316	306	24	,	,	PUNCT
fnp-6316	306	25	scheurlen	scheurlen	PROPN
fnp-6316	306	26	w	w	NOUN
fnp-6316	306	27	,	,	PUNCT
fnp-6316	306	28	geisenberger	geisenberger	ADJ
fnp-6316	306	29	c	c	NOUN
fnp-6316	306	30	,	,	PUNCT
fnp-6316	306	31	rodriguez	rodriguez	PROPN
fnp-6316	306	32	fj	fj	PROPN
fnp-6316	306	33	,	,	PUNCT
fnp-6316	306	34	becker	becker	PROPN
fnp-6316	307	1	a	a	PRON
fnp-6316	307	2	,	,	PUNCT
fnp-6316	307	3	preusser	preusser	PROPN
fnp-6316	307	4	m	m	PROPN
fnp-6316	307	5	,	,	PUNCT
fnp-6316	307	6	haberler	haberler	NOUN
fnp-6316	307	7	c	c	NOUN
fnp-6316	307	8	,	,	PUNCT
fnp-6316	307	9	bjerkvig	bjerkvig	NOUN
fnp-6316	307	10	r	r	NOUN
fnp-6316	307	11	,	,	PUNCT
fnp-6316	307	12	cryan	cryan	PROPN
fnp-6316	307	13	j	j	PROPN
fnp-6316	307	14	,	,	PUNCT
fnp-6316	307	15	farrell	farrell	PROPN
fnp-6316	307	16	m	m	PROPN
fnp-6316	307	17	,	,	PUNCT
fnp-6316	307	18	deckert	deckert	PROPN
fnp-6316	307	19	m	m	PRON
fnp-6316	307	20	,	,	PUNCT
fnp-6316	307	21	hench	hench	PROPN
fnp-6316	307	22	j	j	PROPN
fnp-6316	307	23	,	,	PUNCT
fnp-6316	307	24	frank	frank	PROPN
fnp-6316	307	25	s	s	PROPN
fnp-6316	307	26	,	,	PUNCT
fnp-6316	307	27	serrano	serrano	PROPN
fnp-6316	307	28	j	j	PROPN
fnp-6316	307	29	,	,	PUNCT
fnp-6316	307	30	kannan	kannan	PROPN
fnp-6316	307	31	k	k	PROPN
fnp-6316	307	32	,	,	PUNCT
fnp-6316	307	33	tsirigos	tsirigo	NOUN
fnp-6316	307	34	a	a	DET
fnp-6316	307	35	,	,	PUNCT
fnp-6316	307	36	brück	brück	PROPN
fnp-6316	307	37	w	w	PROPN
fnp-6316	307	38	,	,	PUNCT
fnp-6316	307	39	hofer	hofer	PROPN
fnp-6316	307	40	s	s	PROPN
fnp-6316	307	41	,	,	PUNCT
fnp-6316	307	42	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	PROPN
fnp-6316	307	43	https://biorender.com/	https://biorender.com/	ADJ
fnp-6316	307	44	https://biorender.com/	https://biorender.com/	PROPN
fnp-6316	307	45	https://doi.org/10.1093/clinchem/hvad115	https://doi.org/10.1093/clinchem/hvad115	PROPN
fnp-6316	307	46	https://doi.org/10.1016/j.jss.2024.07.021	https://doi.org/10.1016/j.jss.2024.07.021	PROPN
fnp-6316	307	47	https://doi.org/10.1080/2162402x.2017.1393598	https://doi.org/10.1080/2162402x.2017.1393598	VERB
fnp-6316	307	48	https://doi.org/10.1002/path.4304	https://doi.org/10.1002/path.4304	DET
fnp-6316	307	49	https://doi.org/10.3389/fphar.2017.00193	https://doi.org/10.3389/fphar.2017.00193	PROPN
fnp-6316	307	50	https://doi.org/10.1016/j.ejca.2014.12.014	https://doi.org/10.1016/j.ejca.2014.12.014	VERB
fnp-6316	307	51	free	free	ADJ
fnp-6316	307	52	neuropathology	neuropathology	NOUN
fnp-6316	307	53	6:10	6:10	NUM
fnp-6316	307	54	(	(	PUNCT
fnp-6316	307	55	2025	2025	NUM
fnp-6316	307	56	)	)	PUNCT
fnp-6316	307	57	michel	michel	PROPN
fnp-6316	307	58	mittelbronn	mittelbronn	PROPN
fnp-6316	307	59	doi	doi	PROPN
fnp-6316	307	60	:	:	PUNCT
fnp-6316	307	61	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	307	62	page	page	NOUN
fnp-6316	307	63	18	18	NUM
fnp-6316	307	64	of	of	ADP
fnp-6316	307	65	19	19	NUM
fnp-6316	307	66	brehmer	brehmer	PROPN
fnp-6316	307	67	s	s	PROPN
fnp-6316	307	68	,	,	PUNCT
fnp-6316	307	69	seiz	seiz	PROPN
fnp-6316	307	70	-	-	PUNCT
fnp-6316	307	71	rosenhagen	rosenhagen	PROPN
fnp-6316	307	72	m	m	PROPN
fnp-6316	307	73	,	,	PUNCT
fnp-6316	307	74	hänggi	hänggi	PROPN
fnp-6316	307	75	d	d	PROPN
fnp-6316	307	76	,	,	PUNCT
fnp-6316	307	77	hans	hans	PROPN
fnp-6316	307	78	v	v	PROPN
fnp-6316	307	79	,	,	PUNCT
fnp-6316	307	80	rozsnoki	rozsnoki	NOUN
fnp-6316	307	81	s	s	PROPN
fnp-6316	307	82	,	,	PUNCT
fnp-6316	307	83	hansford	hansford	PROPN
fnp-6316	307	84	jr	jr	PROPN
fnp-6316	307	85	,	,	PUNCT
fnp-6316	307	86	kohlhof	kohlhof	PROPN
fnp-6316	307	87	p	p	PROPN
fnp-6316	307	88	,	,	PUNCT
fnp-6316	307	89	kristensen	kristensen	PROPN
fnp-6316	307	90	bw	bw	PROPN
fnp-6316	307	91	,	,	PUNCT
fnp-6316	307	92	lechner	lechner	PROPN
fnp-6316	307	93	m	m	PROPN
fnp-6316	307	94	,	,	PUNCT
fnp-6316	307	95	lopes	lopes	PROPN
fnp-6316	307	96	b	b	PROPN
fnp-6316	307	97	,	,	PUNCT
fnp-6316	307	98	mawrin	mawrin	NOUN
fnp-6316	307	99	c	c	NOUN
fnp-6316	307	100	,	,	PUNCT
fnp-6316	307	101	ketter	ketter	NOUN
fnp-6316	307	102	r	r	NOUN
fnp-6316	307	103	,	,	PUNCT
fnp-6316	307	104	kulozik	kulozik	NOUN
fnp-6316	307	105	a	a	PRON
fnp-6316	307	106	,	,	PUNCT
fnp-6316	307	107	khatib	khatib	PROPN
fnp-6316	307	108	z	z	PROPN
fnp-6316	307	109	,	,	PUNCT
fnp-6316	307	110	heppner	heppner	PROPN
fnp-6316	307	111	f	f	PROPN
fnp-6316	307	112	,	,	PUNCT
fnp-6316	307	113	koch	koch	PROPN
fnp-6316	307	114	a	a	PRON
fnp-6316	307	115	,	,	PUNCT
fnp-6316	307	116	jouvet	jouvet	NOUN
fnp-6316	307	117	a	a	PRON
fnp-6316	307	118	,	,	PUNCT
fnp-6316	307	119	keohane	keohane	PROPN
fnp-6316	307	120	c	c	NOUN
fnp-6316	307	121	,	,	PUNCT
fnp-6316	307	122	mühleisen	mühleisen	VERB
fnp-6316	307	123	h	h	NOUN
fnp-6316	307	124	,	,	PUNCT
fnp-6316	307	125	mueller	mueller	PROPN
fnp-6316	307	126	w	w	PROPN
fnp-6316	307	127	,	,	PUNCT
fnp-6316	307	128	pohl	pohl	PROPN
fnp-6316	307	129	u	u	PROPN
fnp-6316	307	130	,	,	PUNCT
fnp-6316	307	131	prinz	prinz	PROPN
fnp-6316	307	132	m	m	PROPN
fnp-6316	307	133	,	,	PUNCT
fnp-6316	307	134	benner	benner	PROPN
fnp-6316	307	135	a	a	PROPN
fnp-6316	307	136	,	,	PUNCT
fnp-6316	307	137	zapatka	zapatka	PROPN
fnp-6316	307	138	m	m	PROPN
fnp-6316	307	139	,	,	PUNCT
fnp-6316	307	140	gottardo	gottardo	PROPN
fnp-6316	307	141	ng	ng	PROPN
fnp-6316	307	142	,	,	PUNCT
fnp-6316	307	143	driever	driever	NOUN
fnp-6316	307	144	ph	ph	PROPN
fnp-6316	307	145	,	,	PUNCT
fnp-6316	307	146	kramm	kramm	PROPN
fnp-6316	307	147	cm	cm	PROPN
fnp-6316	307	148	,	,	PUNCT
fnp-6316	307	149	müller	müller	PROPN
fnp-6316	307	150	hl	hl	PROPN
fnp-6316	307	151	,	,	PUNCT
fnp-6316	307	152	rutkowski	rutkowski	PROPN
fnp-6316	307	153	s	s	PROPN
fnp-6316	307	154	,	,	PUNCT
fnp-6316	307	155	von	von	PROPN
fnp-6316	307	156	hoff	hoff	PROPN
fnp-6316	307	157	k	k	PROPN
fnp-6316	307	158	,	,	PUNCT
fnp-6316	307	159	frühwald	frühwald	PROPN
fnp-6316	307	160	mc	mc	PROPN
fnp-6316	307	161	,	,	PUNCT
fnp-6316	307	162	gnekow	gnekow	ADV
fnp-6316	307	163	a	a	DET
fnp-6316	307	164	,	,	PUNCT
fnp-6316	307	165	fleischhack	fleischhack	NOUN
fnp-6316	307	166	g	g	NOUN
fnp-6316	307	167	,	,	PUNCT
fnp-6316	307	168	tippelt	tippelt	NOUN
fnp-6316	307	169	s	s	NOUN
fnp-6316	307	170	,	,	PUNCT
fnp-6316	307	171	calaminus	calaminus	NOUN
fnp-6316	307	172	g	g	NOUN
fnp-6316	307	173	,	,	PUNCT
fnp-6316	307	174	monoranu	monoranu	NOUN
fnp-6316	307	175	cm	cm	PROPN
fnp-6316	307	176	,	,	PUNCT
fnp-6316	307	177	perry	perry	PROPN
fnp-6316	307	178	a	a	PROPN
fnp-6316	307	179	,	,	PUNCT
fnp-6316	307	180	jones	jones	PROPN
fnp-6316	307	181	c	c	PROPN
fnp-6316	307	182	,	,	PUNCT
fnp-6316	307	183	jacques	jacques	PROPN
fnp-6316	307	184	ts	ts	PROPN
fnp-6316	307	185	,	,	PUNCT
fnp-6316	307	186	radlwimmer	radlwimmer	PROPN
fnp-6316	307	187	b	b	PROPN
fnp-6316	307	188	,	,	PUNCT
fnp-6316	307	189	gessi	gessi	PROPN
fnp-6316	307	190	m	m	PROPN
fnp-6316	307	191	,	,	PUNCT
fnp-6316	307	192	pietsch	pietsch	VERB
fnp-6316	307	193	t	t	PROPN
fnp-6316	307	194	,	,	PUNCT
fnp-6316	307	195	schramm	schramm	PROPN
fnp-6316	307	196	j	j	PROPN
fnp-6316	307	197	,	,	PUNCT
fnp-6316	307	198	schackert	schackert	PROPN
fnp-6316	307	199	g	g	PROPN
fnp-6316	307	200	,	,	PUNCT
fnp-6316	307	201	westphal	westphal	PROPN
fnp-6316	307	202	m	m	PROPN
fnp-6316	307	203	,	,	PUNCT
fnp-6316	307	204	reifenberger	reifenberger	VERB
fnp-6316	307	205	g	g	NOUN
fnp-6316	307	206	,	,	PUNCT
fnp-6316	307	207	wesseling	wessele	VERB
fnp-6316	307	208	p	p	PRON
fnp-6316	307	209	,	,	PUNCT
fnp-6316	307	210	weller	weller	PROPN
fnp-6316	307	211	m	m	PROPN
fnp-6316	307	212	,	,	PUNCT
fnp-6316	307	213	collins	collins	PROPN
fnp-6316	307	214	vp	vp	PROPN
fnp-6316	307	215	,	,	PUNCT
fnp-6316	307	216	blümcke	blümcke	PROPN
fnp-6316	307	217	i	i	PROPN
fnp-6316	307	218	,	,	PUNCT
fnp-6316	307	219	bendszus	bendszus	PROPN
fnp-6316	307	220	m	m	PROPN
fnp-6316	307	221	,	,	PUNCT
fnp-6316	307	222	debus	debus	PROPN
fnp-6316	307	223	j	j	PROPN
fnp-6316	307	224	,	,	PUNCT
fnp-6316	307	225	huang	huang	PROPN
fnp-6316	307	226	a	a	PROPN
fnp-6316	307	227	,	,	PUNCT
fnp-6316	307	228	jabado	jabado	ADJ
fnp-6316	307	229	n	n	CCONJ
fnp-6316	307	230	,	,	PUNCT
fnp-6316	307	231	northcott	northcott	PROPN
fnp-6316	307	232	pa	pa	PROPN
fnp-6316	307	233	,	,	PUNCT
fnp-6316	307	234	paulus	paulus	PROPN
fnp-6316	307	235	w	w	PROPN
fnp-6316	307	236	,	,	PUNCT
fnp-6316	307	237	gajjar	gajjar	NOUN
fnp-6316	307	238	a	a	PRON
fnp-6316	307	239	,	,	PUNCT
fnp-6316	307	240	robinson	robinson	PROPN
fnp-6316	307	241	gw	gw	PROPN
fnp-6316	307	242	,	,	PUNCT
fnp-6316	307	243	taylor	taylor	PROPN
fnp-6316	307	244	md	md	PROPN
fnp-6316	307	245	,	,	PUNCT
fnp-6316	307	246	jaunmuktane	jaunmuktane	PROPN
fnp-6316	307	247	z	z	PROPN
fnp-6316	307	248	,	,	PUNCT
fnp-6316	307	249	ryzhova	ryzhova	PROPN
fnp-6316	307	250	m	m	PROPN
fnp-6316	307	251	,	,	PUNCT
fnp-6316	307	252	platten	platten	PROPN
fnp-6316	307	253	m	m	PROPN
fnp-6316	307	254	,	,	PUNCT
fnp-6316	307	255	unterberg	unterberg	PROPN
fnp-6316	307	256	a	a	PRON
fnp-6316	307	257	,	,	PUNCT
fnp-6316	307	258	wick	wick	PROPN
fnp-6316	307	259	w	w	PROPN
fnp-6316	307	260	,	,	PUNCT
fnp-6316	307	261	karajannis	karajannis	PROPN
fnp-6316	307	262	ma	ma	PROPN
fnp-6316	307	263	,	,	PUNCT
fnp-6316	307	264	mittelbronn	mittelbronn	PROPN
fnp-6316	307	265	m	m	PROPN
fnp-6316	307	266	,	,	PUNCT
fnp-6316	307	267	acker	acker	PROPN
fnp-6316	307	268	t	t	PROPN
fnp-6316	307	269	,	,	PUNCT
fnp-6316	307	270	hartmann	hartmann	PROPN
fnp-6316	307	271	c	c	PROPN
fnp-6316	307	272	,	,	PUNCT
fnp-6316	307	273	aldape	aldape	PROPN
fnp-6316	307	274	k	k	PROPN
fnp-6316	307	275	,	,	PUNCT
fnp-6316	307	276	schüller	schüll	ADJ
fnp-6316	307	277	u	u	NOUN
fnp-6316	307	278	,	,	PUNCT
fnp-6316	307	279	buslei	buslei	NOUN
fnp-6316	307	280	r	r	NOUN
fnp-6316	307	281	,	,	PUNCT
fnp-6316	307	282	lichter	lichter	PROPN
fnp-6316	307	283	p	p	PROPN
fnp-6316	307	284	,	,	PUNCT
fnp-6316	307	285	kool	kool	PROPN
fnp-6316	307	286	m	m	PROPN
fnp-6316	307	287	,	,	PUNCT
fnp-6316	307	288	herold	herold	PROPN
fnp-6316	307	289	-	-	PUNCT
fnp-6316	307	290	mende	mende	PROPN
fnp-6316	307	291	c	c	PROPN
fnp-6316	307	292	,	,	PUNCT
fnp-6316	307	293	ellison	ellison	PROPN
fnp-6316	307	294	dw	dw	PROPN
fnp-6316	307	295	,	,	PUNCT
fnp-6316	307	296	hasselblatt	hasselblatt	PROPN
fnp-6316	307	297	m	m	PROPN
fnp-6316	307	298	,	,	PUNCT
fnp-6316	307	299	snuderl	snuderl	PROPN
fnp-6316	307	300	m	m	PROPN
fnp-6316	307	301	,	,	PUNCT
fnp-6316	307	302	brandner	brandner	PROPN
fnp-6316	307	303	s	s	PROPN
fnp-6316	307	304	,	,	PUNCT
fnp-6316	307	305	korshunov	korshunov	PROPN
fnp-6316	307	306	a	a	PROPN
fnp-6316	307	307	,	,	PUNCT
fnp-6316	307	308	von	von	PROPN
fnp-6316	307	309	deimling	deimle	VERB
fnp-6316	307	310	a	a	PRON
fnp-6316	307	311	,	,	PUNCT
fnp-6316	308	1	pfister	pfister	NOUN
fnp-6316	308	2	sm	sm	PROPN
fnp-6316	308	3	.	.	PROPN
fnp-6316	308	4	dna	dna	PROPN
fnp-6316	308	5	methylation	methylation	NOUN
fnp-6316	308	6	-	-	PUNCT
fnp-6316	308	7	based	base	VERB
fnp-6316	308	8	classification	classification	NOUN
fnp-6316	308	9	of	of	ADP
fnp-6316	308	10	central	central	ADJ
fnp-6316	308	11	nervous	nervous	ADJ
fnp-6316	308	12	system	system	NOUN
fnp-6316	308	13	tumours	tumour	VERB
fnp-6316	308	14	.	.	PUNCT
fnp-6316	309	1	nature	nature	NOUN
fnp-6316	309	2	.	.	PUNCT
fnp-6316	310	1	2018	2018	NUM
fnp-6316	310	2	mar	mar	PROPN
fnp-6316	310	3	22;555(7697):469	22;555(7697):469	NUM
fnp-6316	310	4	-	-	SYM
fnp-6316	310	5	474	474	NUM
fnp-6316	310	6	.	.	PUNCT
fnp-6316	310	7	https://doi.org/10.1038/nature26000	https://doi.org/10.1038/nature26000	PROPN
fnp-6316	310	8	8	8	NUM
fnp-6316	310	9	.	.	PUNCT
fnp-6316	311	1	chen	chen	PROPN
fnp-6316	311	2	hc	hc	PROPN
fnp-6316	311	3	,	,	PUNCT
fnp-6316	311	4	he	he	PRON
fnp-6316	311	5	p	p	NOUN
fnp-6316	311	6	,	,	PUNCT
fnp-6316	311	7	mcdonald	mcdonald	PROPN
fnp-6316	311	8	m	m	PROPN
fnp-6316	311	9	,	,	PUNCT
fnp-6316	311	10	williamson	williamson	PROPN
fnp-6316	311	11	mr	mr	PROPN
fnp-6316	311	12	,	,	PUNCT
fnp-6316	311	13	varadharajan	varadharajan	NOUN
fnp-6316	311	14	s	s	PROPN
fnp-6316	311	15	,	,	PUNCT
fnp-6316	311	16	lozzi	lozzi	ADJ
fnp-6316	311	17	b	b	NOUN
fnp-6316	311	18	,	,	PUNCT
fnp-6316	311	19	woo	woo	PROPN
fnp-6316	311	20	j	j	PROPN
fnp-6316	311	21	,	,	PUNCT
fnp-6316	311	22	choi	choi	NOUN
fnp-6316	311	23	dj	dj	PROPN
fnp-6316	311	24	,	,	PUNCT
fnp-6316	311	25	sardar	sardar	PROPN
fnp-6316	311	26	d	d	PROPN
fnp-6316	311	27	,	,	PUNCT
fnp-6316	311	28	huang	huang	PROPN
fnp-6316	311	29	-	-	PUNCT
fnp-6316	311	30	hobbs	hobbs	PROPN
fnp-6316	311	31	e	e	PROPN
fnp-6316	311	32	,	,	PUNCT
fnp-6316	311	33	sun	sun	PROPN
fnp-6316	311	34	h	h	PROPN
fnp-6316	311	35	,	,	PUNCT
fnp-6316	311	36	ippagunta	ippagunta	PROPN
fnp-6316	311	37	sm	sm	PROPN
fnp-6316	311	38	,	,	PUNCT
fnp-6316	311	39	jain	jain	PROPN
fnp-6316	311	40	a	a	PRON
fnp-6316	311	41	,	,	PUNCT
fnp-6316	311	42	rao	rao	NOUN
fnp-6316	311	43	g	g	NOUN
fnp-6316	311	44	,	,	PUNCT
fnp-6316	311	45	merchant	merchant	NOUN
fnp-6316	311	46	te	te	PROPN
fnp-6316	311	47	,	,	PUNCT
fnp-6316	311	48	ellison	ellison	PROPN
fnp-6316	311	49	dw	dw	PROPN
fnp-6316	311	50	,	,	PUNCT
fnp-6316	311	51	noebels	noebels	PROPN
fnp-6316	311	52	jl	jl	PROPN
fnp-6316	311	53	,	,	PUNCT
fnp-6316	311	54	bertrand	bertrand	PROPN
fnp-6316	311	55	kc	kc	PROPN
fnp-6316	311	56	,	,	PUNCT
fnp-6316	311	57	mack	mack	PROPN
fnp-6316	311	58	sc	sc	PROPN
fnp-6316	311	59	,	,	PUNCT
fnp-6316	311	60	deneen	deneen	PROPN
fnp-6316	311	61	b.	b.	PROPN
fnp-6316	311	62	histone	histone	PROPN
fnp-6316	311	63	serotonylation	serotonylation	PROPN
fnp-6316	311	64	regulates	regulate	VERB
fnp-6316	311	65	ependymoma	ependymoma	NOUN
fnp-6316	311	66	tumorigenesis	tumorigenesis	NOUN
fnp-6316	311	67	.	.	PUNCT
fnp-6316	312	1	nature	nature	NOUN
fnp-6316	312	2	.	.	PUNCT
fnp-6316	313	1	2024	2024	NUM
fnp-6316	313	2	aug;632(8026):903	aug;632(8026):903	NOUN
fnp-6316	313	3	-	-	PUNCT
fnp-6316	313	4	910	910	NUM
fnp-6316	313	5	.	.	PUNCT
fnp-6316	314	1	https://doi.org/10.1038/s41586-024-07751-z	https://doi.org/10.1038/s41586-024-07751-z	PROPN
fnp-6316	314	2	9	9	NUM
fnp-6316	314	3	.	.	PUNCT
fnp-6316	315	1	choi	choi	PROPN
fnp-6316	315	2	hj	hj	PROPN
fnp-6316	315	3	,	,	PUNCT
fnp-6316	315	4	choi	choi	PROPN
fnp-6316	315	5	sh	sh	PROPN
fnp-6316	315	6	,	,	PUNCT
fnp-6316	315	7	you	you	PRON
fnp-6316	315	8	sh	sh	PROPN
fnp-6316	315	9	,	,	PUNCT
fnp-6316	315	10	yoo	yoo	PROPN
fnp-6316	315	11	re	re	PROPN
fnp-6316	315	12	,	,	PUNCT
fnp-6316	315	13	kang	kang	PROPN
fnp-6316	315	14	km	km	PROPN
fnp-6316	315	15	,	,	PUNCT
fnp-6316	315	16	yun	yun	PROPN
fnp-6316	315	17	tj	tj	PROPN
fnp-6316	315	18	,	,	PUNCT
fnp-6316	315	19	kim	kim	PROPN
fnp-6316	315	20	jh	jh	PROPN
fnp-6316	315	21	,	,	PUNCT
fnp-6316	315	22	sohn	sohn	PROPN
fnp-6316	315	23	ch	ch	PROPN
fnp-6316	315	24	,	,	PUNCT
fnp-6316	315	25	park	park	NOUN
fnp-6316	315	26	ck	ck	PROPN
fnp-6316	315	27	,	,	PUNCT
fnp-6316	315	28	park	park	PROPN
fnp-6316	315	29	sh	sh	PROPN
fnp-6316	315	30	.	.	PROPN
fnp-6316	315	31	mgmt	mgmt	PROPN
fnp-6316	315	32	promoter	promoter	NOUN
fnp-6316	315	33	methylation	methylation	NOUN
fnp-6316	315	34	status	status	NOUN
fnp-6316	315	35	in	in	ADP
fnp-6316	315	36	initial	initial	ADJ
fnp-6316	315	37	and	and	CCONJ
fnp-6316	315	38	recurrent	recurrent	ADJ
fnp-6316	315	39	glioblastoma	glioblastoma	NOUN
fnp-6316	315	40	:	:	PUNCT
fnp-6316	315	41	correlation	correlation	NOUN
fnp-6316	315	42	study	study	NOUN
fnp-6316	315	43	with	with	ADP
fnp-6316	315	44	dwi	dwi	PROPN
fnp-6316	315	45	and	and	CCONJ
fnp-6316	315	46	dsc	dsc	PROPN
fnp-6316	315	47	pwi	pwi	PROPN
fnp-6316	315	48	features	feature	VERB
fnp-6316	315	49	.	.	PUNCT
fnp-6316	316	1	ajnr	ajnr	PROPN
fnp-6316	316	2	am	be	AUX
fnp-6316	316	3	j	j	PROPN
fnp-6316	316	4	neuroradiol	neuroradiol	PROPN
fnp-6316	316	5	.	.	PUNCT
fnp-6316	317	1	2021	2021	NUM
fnp-6316	317	2	may;42(5):853	may;42(5):853	NOUN
fnp-6316	317	3	-	-	PUNCT
fnp-6316	317	4	860	860	NUM
fnp-6316	317	5	.	.	PUNCT
fnp-6316	318	1	https://doi.org/10.3174/ajnr.a7004	https://doi.org/10.3174/ajnr.a7004	NOUN
fnp-6316	318	2	10	10	NUM
fnp-6316	318	3	.	.	PUNCT
fnp-6316	319	1	dejaegher	dejaegher	PROPN
fnp-6316	319	2	j	j	PROPN
fnp-6316	319	3	,	,	PUNCT
fnp-6316	319	4	solie	solie	PROPN
fnp-6316	319	5	l	l	NOUN
fnp-6316	319	6	,	,	PUNCT
fnp-6316	319	7	hunin	hunin	PROPN
fnp-6316	319	8	z	z	NOUN
fnp-6316	319	9	,	,	PUNCT
fnp-6316	319	10	sciot	sciot	NOUN
fnp-6316	319	11	r	r	NOUN
fnp-6316	319	12	,	,	PUNCT
fnp-6316	319	13	capper	capper	NOUN
fnp-6316	319	14	d	d	NOUN
fnp-6316	319	15	,	,	PUNCT
fnp-6316	319	16	siewert	siewert	PROPN
fnp-6316	319	17	c	c	NOUN
fnp-6316	319	18	,	,	PUNCT
fnp-6316	319	19	van	van	PROPN
fnp-6316	319	20	cauter	cauter	NOUN
fnp-6316	319	21	s	s	PROPN
fnp-6316	319	22	,	,	PUNCT
fnp-6316	319	23	wilms	wilm	NOUN
fnp-6316	319	24	g	g	NOUN
fnp-6316	319	25	,	,	PUNCT
fnp-6316	319	26	van	van	PROPN
fnp-6316	319	27	loon	loon	PROPN
fnp-6316	319	28	j	j	PROPN
fnp-6316	319	29	,	,	PUNCT
fnp-6316	319	30	ectors	ectors	PROPN
fnp-6316	319	31	n	n	AUX
fnp-6316	319	32	,	,	PUNCT
fnp-6316	319	33	fieuws	fieuws	PROPN
fnp-6316	319	34	s	s	PART
fnp-6316	319	35	,	,	PUNCT
fnp-6316	319	36	pfister	pfister	PROPN
fnp-6316	319	37	sm	sm	PROPN
fnp-6316	319	38	,	,	PUNCT
fnp-6316	319	39	van	van	PROPN
fnp-6316	319	40	gool	gool	PROPN
fnp-6316	319	41	sw	sw	PROPN
fnp-6316	319	42	,	,	PUNCT
fnp-6316	319	43	de	de	PROPN
fnp-6316	319	44	vleeschouwer	vleeschouwer	PROPN
fnp-6316	319	45	s.	s.	PROPN
fnp-6316	319	46	neuro	neuro	PROPN
fnp-6316	319	47	oncol	oncol	PROPN
fnp-6316	319	48	.	.	PUNCT
fnp-6316	320	1	2021	2021	NUM
fnp-6316	320	2	feb	feb	PROPN
fnp-6316	320	3	25;23(2):240	25;23(2):240	NUM
fnp-6316	320	4	-	-	SYM
fnp-6316	320	5	250	250	NUM
fnp-6316	320	6	.	.	PUNCT
fnp-6316	320	7	https://doi.org/10.1093/neuonc/noaa247	https://doi.org/10.1093/neuonc/noaa247	NOUN
fnp-6316	320	8	11	11	NUM
fnp-6316	320	9	.	.	PUNCT
fnp-6316	320	10	dirkse	dirkse	NOUN
fnp-6316	320	11	a	a	PRON
fnp-6316	320	12	,	,	PUNCT
fnp-6316	320	13	golebiewska	golebiewska	NOUN
fnp-6316	320	14	a	a	NOUN
fnp-6316	320	15	,	,	PUNCT
fnp-6316	320	16	buder	buder	PROPN
fnp-6316	320	17	t	t	PROPN
fnp-6316	320	18	,	,	PUNCT
fnp-6316	320	19	nazarov	nazarov	ADJ
fnp-6316	320	20	pv	pv	NOUN
fnp-6316	320	21	,	,	PUNCT
fnp-6316	320	22	muller	muller	NOUN
fnp-6316	320	23	a	a	NOUN
fnp-6316	320	24	,	,	PUNCT
fnp-6316	320	25	poovathingal	poovathingal	PROPN
fnp-6316	320	26	s	s	NOUN
fnp-6316	320	27	,	,	PUNCT
fnp-6316	320	28	brons	brons	PROPN
fnp-6316	320	29	nhc	nhc	PROPN
fnp-6316	320	30	,	,	PUNCT
fnp-6316	320	31	leite	leite	PROPN
fnp-6316	320	32	s	s	PROPN
fnp-6316	320	33	,	,	PUNCT
fnp-6316	320	34	sauvageot	sauvageot	ADJ
fnp-6316	320	35	n	n	CCONJ
fnp-6316	320	36	,	,	PUNCT
fnp-6316	320	37	sarkisjan	sarkisjan	PROPN
fnp-6316	320	38	d	d	PROPN
fnp-6316	320	39	,	,	PUNCT
fnp-6316	320	40	seyfrid	seyfrid	VERB
fnp-6316	320	41	m	m	PROPN
fnp-6316	320	42	,	,	PUNCT
fnp-6316	320	43	fritah	fritah	PROPN
fnp-6316	320	44	s	s	PART
fnp-6316	320	45	,	,	PUNCT
fnp-6316	320	46	stieber	stieber	PROPN
fnp-6316	320	47	d	d	PROPN
fnp-6316	320	48	,	,	PUNCT
fnp-6316	320	49	michelucci	michelucci	VERB
fnp-6316	320	50	a	a	PRON
fnp-6316	320	51	,	,	PUNCT
fnp-6316	320	52	hertel	hertel	PROPN
fnp-6316	320	53	f	f	PROPN
fnp-6316	320	54	,	,	PUNCT
fnp-6316	320	55	herold	herold	PROPN
fnp-6316	320	56	-	-	PUNCT
fnp-6316	320	57	mende	mende	PROPN
fnp-6316	320	58	c	c	PROPN
fnp-6316	320	59	,	,	PUNCT
fnp-6316	320	60	azuaje	azuaje	PROPN
fnp-6316	320	61	f	f	PROPN
fnp-6316	320	62	,	,	PUNCT
fnp-6316	320	63	skupin	skupin	PROPN
fnp-6316	320	64	a	a	NOUN
fnp-6316	320	65	,	,	PUNCT
fnp-6316	320	66	bjerkvig	bjerkvig	NOUN
fnp-6316	320	67	r	r	NOUN
fnp-6316	320	68	,	,	PUNCT
fnp-6316	320	69	deutsch	deutsch	VERB
fnp-6316	320	70	a	a	PRON
fnp-6316	320	71	,	,	PUNCT
fnp-6316	320	72	voss	voss	NOUN
fnp-6316	320	73	-	-	NOUN
fnp-6316	320	74	böhme	böhme	VERB
fnp-6316	320	75	a	a	DET
fnp-6316	320	76	,	,	PUNCT
fnp-6316	320	77	niclou	niclou	ADJ
fnp-6316	320	78	sp	sp	PROPN
fnp-6316	320	79	.	.	PROPN
fnp-6316	320	80	stem	stem	NOUN
fnp-6316	320	81	cellassociated	cellassociate	VERB
fnp-6316	320	82	heterogeneity	heterogeneity	NOUN
fnp-6316	320	83	in	in	ADP
fnp-6316	320	84	glioblastoma	glioblastoma	NOUN
fnp-6316	320	85	results	result	NOUN
fnp-6316	320	86	from	from	ADP
fnp-6316	320	87	intrinsic	intrinsic	ADJ
fnp-6316	320	88	tumor	tumor	NOUN
fnp-6316	320	89	plasticity	plasticity	NOUN
fnp-6316	320	90	shaped	shape	VERB
fnp-6316	320	91	by	by	ADP
fnp-6316	320	92	the	the	DET
fnp-6316	320	93	microenvironment	microenvironment	NOUN
fnp-6316	320	94	.	.	PUNCT
fnp-6316	321	1	nat	nat	PROPN
fnp-6316	321	2	commun	commun	PROPN
fnp-6316	321	3	.	.	PUNCT
fnp-6316	322	1	2019	2019	NUM
fnp-6316	322	2	apr	apr	NOUN
fnp-6316	322	3	16;10(1):1787	16;10(1):1787	NUM
fnp-6316	322	4	.	.	PUNCT
fnp-6316	323	1	https://doi.org/10.1038/s41467-019-09853-z	https://doi.org/10.1038/s41467-019-09853-z	PROPN
fnp-6316	323	2	12	12	NUM
fnp-6316	323	3	.	.	PUNCT
fnp-6316	324	1	dobersalske	dobersalske	PROPN
fnp-6316	324	2	c	c	PROPN
fnp-6316	324	3	,	,	PUNCT
fnp-6316	324	4	rauschenbach	rauschenbach	PROPN
fnp-6316	324	5	l	l	PROPN
fnp-6316	324	6	,	,	PUNCT
fnp-6316	324	7	hua	hua	PROPN
fnp-6316	324	8	y	y	PROPN
fnp-6316	324	9	,	,	PUNCT
fnp-6316	324	10	berliner	berliner	PROPN
fnp-6316	324	11	c	c	AUX
fnp-6316	324	12	,	,	PUNCT
fnp-6316	324	13	steinbach	steinbach	PROPN
fnp-6316	324	14	a	a	PRON
fnp-6316	324	15	,	,	PUNCT
fnp-6316	324	16	grüneboom	grüneboom	NOUN
fnp-6316	324	17	a	a	PRON
fnp-6316	324	18	,	,	PUNCT
fnp-6316	324	19	kokkaliaris	kokkaliaris	PROPN
fnp-6316	324	20	kd	kd	PROPN
fnp-6316	324	21	,	,	PUNCT
fnp-6316	324	22	heiland	heiland	PROPN
fnp-6316	324	23	dh	dh	PROPN
fnp-6316	324	24	,	,	PUNCT
fnp-6316	324	25	berger	berger	PROPN
fnp-6316	324	26	p	p	X
fnp-6316	324	27	,	,	PUNCT
fnp-6316	324	28	langer	langer	PROPN
fnp-6316	324	29	s	s	PART
fnp-6316	324	30	,	,	PUNCT
fnp-6316	324	31	tan	tan	PROPN
fnp-6316	324	32	cl	cl	NOUN
fnp-6316	324	33	,	,	PUNCT
fnp-6316	324	34	stenzel	stenzel	PROPN
fnp-6316	324	35	m	m	PROPN
fnp-6316	324	36	,	,	PUNCT
fnp-6316	324	37	landolsi	landolsi	VERB
fnp-6316	324	38	s	s	PROPN
fnp-6316	324	39	,	,	PUNCT
fnp-6316	324	40	weber	weber	PROPN
fnp-6316	324	41	f	f	X
fnp-6316	324	42	,	,	PUNCT
fnp-6316	324	43	darkwah	darkwah	NOUN
fnp-6316	324	44	oppong	oppong	PROPN
fnp-6316	324	45	m	m	PROPN
fnp-6316	324	46	,	,	PUNCT
fnp-6316	324	47	werner	werner	PROPN
fnp-6316	324	48	ra	ra	PROPN
fnp-6316	324	49	,	,	PUNCT
fnp-6316	324	50	gull	gull	NOUN
fnp-6316	324	51	h	h	PROPN
fnp-6316	324	52	,	,	PUNCT
fnp-6316	324	53	schröder	schröder	PROPN
fnp-6316	324	54	t	t	PROPN
fnp-6316	324	55	,	,	PUNCT
fnp-6316	324	56	linsenmann	linsenmann	PROPN
fnp-6316	324	57	t	t	PROPN
fnp-6316	324	58	,	,	PUNCT
fnp-6316	324	59	buck	buck	PROPN
fnp-6316	324	60	ak	ak	PROPN
fnp-6316	324	61	,	,	PUNCT
fnp-6316	324	62	gunzer	gunzer	NOUN
fnp-6316	324	63	m	m	PROPN
fnp-6316	324	64	,	,	PUNCT
fnp-6316	324	65	stuschke	stuschke	PROPN
fnp-6316	324	66	m	m	PROPN
fnp-6316	324	67	,	,	PUNCT
fnp-6316	324	68	keyvani	keyvani	PROPN
fnp-6316	324	69	k	k	PROPN
fnp-6316	324	70	,	,	PUNCT
fnp-6316	324	71	forsting	forste	VERB
fnp-6316	324	72	m	m	PROPN
fnp-6316	324	73	,	,	PUNCT
fnp-6316	324	74	glas	glas	PROPN
fnp-6316	324	75	m	m	PROPN
fnp-6316	324	76	,	,	PUNCT
fnp-6316	324	77	kipnis	kipnis	PROPN
fnp-6316	324	78	j	j	PROPN
fnp-6316	324	79	,	,	PUNCT
fnp-6316	324	80	steindler	steindler	ADJ
fnp-6316	324	81	da	da	NOUN
fnp-6316	324	82	,	,	PUNCT
fnp-6316	324	83	reinhardt	reinhardt	PROPN
fnp-6316	324	84	hc	hc	PROPN
fnp-6316	324	85	,	,	PUNCT
fnp-6316	324	86	green	green	PROPN
fnp-6316	324	87	ew	ew	PROPN
fnp-6316	324	88	,	,	PUNCT
fnp-6316	324	89	platten	platten	PROPN
fnp-6316	324	90	m	m	PROPN
fnp-6316	324	91	,	,	PUNCT
fnp-6316	324	92	tasdogan	tasdogan	VERB
fnp-6316	324	93	a	a	PRON
fnp-6316	324	94	,	,	PUNCT
fnp-6316	324	95	herrmann	herrmann	PROPN
fnp-6316	324	96	k	k	PROPN
fnp-6316	324	97	,	,	PUNCT
fnp-6316	324	98	rambow	rambow	PROPN
fnp-6316	324	99	f	f	PROPN
fnp-6316	324	100	,	,	PUNCT
fnp-6316	324	101	cima	cima	PROPN
fnp-6316	324	102	i	i	PROPN
fnp-6316	324	103	,	,	PUNCT
fnp-6316	324	104	sure	sure	ADJ
fnp-6316	324	105	u	u	NOUN
fnp-6316	324	106	,	,	PUNCT
fnp-6316	324	107	scheffler	scheffler	PROPN
fnp-6316	324	108	b.	b.	PROPN
fnp-6316	324	109	cranioencephalic	cranioencephalic	ADJ
fnp-6316	324	110	functional	functional	ADJ
fnp-6316	324	111	lymphoid	lymphoid	ADJ
fnp-6316	324	112	units	unit	NOUN
fnp-6316	324	113	in	in	ADP
fnp-6316	324	114	glioblastoma	glioblastoma	NOUN
fnp-6316	324	115	.	.	PUNCT
fnp-6316	325	1	nat	nat	PROPN
fnp-6316	325	2	med	med	PROPN
fnp-6316	325	3	.	.	PUNCT
fnp-6316	326	1	2024	2024	NUM
fnp-6316	326	2	oct;30(10):2947	oct;30(10):2947	SYM
fnp-6316	326	3	-	-	SYM
fnp-6316	326	4	2956	2956	NUM
fnp-6316	326	5	https://doi.org/10.1038/s41591-024-03152-x	https://doi.org/10.1038/s41591-024-03152-x	NOUN
fnp-6316	326	6	13	13	NUM
fnp-6316	326	7	.	.	PUNCT
fnp-6316	327	1	drexler	drexler	PROPN
fnp-6316	327	2	r	r	PROPN
fnp-6316	327	3	,	,	PUNCT
fnp-6316	327	4	khatri	khatri	PROPN
fnp-6316	327	5	r	r	PROPN
fnp-6316	327	6	,	,	PUNCT
fnp-6316	327	7	schüller	schüller	ADJ
fnp-6316	327	8	u	u	NOUN
fnp-6316	327	9	,	,	PUNCT
fnp-6316	327	10	eckhardt	eckhardt	PROPN
fnp-6316	327	11	a	a	PRON
fnp-6316	327	12	,	,	PUNCT
fnp-6316	327	13	ryba	ryba	PROPN
fnp-6316	327	14	a	a	PRON
fnp-6316	327	15	,	,	PUNCT
fnp-6316	327	16	sauvigny	sauvigny	PROPN
fnp-6316	327	17	t	t	PROPN
fnp-6316	327	18	,	,	PUNCT
fnp-6316	327	19	dührsen	dührsen	ADJ
fnp-6316	327	20	l	l	NOUN
fnp-6316	327	21	,	,	PUNCT
fnp-6316	327	22	mohme	mohme	PROPN
fnp-6316	327	23	m	m	PROPN
fnp-6316	327	24	,	,	PUNCT
fnp-6316	327	25	ricklefs	ricklefs	PROPN
fnp-6316	327	26	t	t	PROPN
fnp-6316	327	27	,	,	PUNCT
fnp-6316	327	28	bode	bode	VERB
fnp-6316	327	29	h	h	PROPN
fnp-6316	327	30	,	,	PUNCT
fnp-6316	327	31	hausmann	hausmann	PROPN
fnp-6316	327	32	f	f	PROPN
fnp-6316	327	33	,	,	PUNCT
fnp-6316	327	34	huber	huber	PROPN
fnp-6316	327	35	tb	tb	PROPN
fnp-6316	327	36	,	,	PUNCT
fnp-6316	327	37	bonn	bonn	PROPN
fnp-6316	327	38	s	s	PROPN
fnp-6316	327	39	,	,	PUNCT
fnp-6316	327	40	voß	voß	ADP
fnp-6316	327	41	h	h	PROPN
fnp-6316	327	42	,	,	PUNCT
fnp-6316	327	43	neumann	neumann	PROPN
fnp-6316	327	44	je	je	PROPN
fnp-6316	327	45	,	,	PUNCT
fnp-6316	327	46	silverbush	silverbush	NOUN
fnp-6316	327	47	d	d	PROPN
fnp-6316	327	48	,	,	PUNCT
fnp-6316	327	49	hovestadt	hovestadt	ADJ
fnp-6316	327	50	v	v	NOUN
fnp-6316	327	51	,	,	PUNCT
fnp-6316	327	52	suvà	suvà	NOUN
fnp-6316	327	53	ml	ml	VERB
fnp-6316	327	54	,	,	PUNCT
fnp-6316	327	55	lamszus	lamszus	PROPN
fnp-6316	327	56	k	k	PROPN
fnp-6316	327	57	,	,	PUNCT
fnp-6316	327	58	gempt	gempt	PROPN
fnp-6316	327	59	j	j	PROPN
fnp-6316	327	60	,	,	PUNCT
fnp-6316	327	61	westphal	westphal	PROPN
fnp-6316	327	62	m	m	PROPN
fnp-6316	327	63	,	,	PUNCT
fnp-6316	327	64	heiland	heiland	PROPN
fnp-6316	327	65	dh	dh	PROPN
fnp-6316	327	66	,	,	PUNCT
fnp-6316	327	67	hänzelmann	hänzelmann	PROPN
fnp-6316	327	68	s	s	PART
fnp-6316	327	69	,	,	PUNCT
fnp-6316	327	70	ricklefs	ricklefs	PROPN
fnp-6316	327	71	fl	fl	PROPN
fnp-6316	327	72	.	.	PUNCT
fnp-6316	328	1	temporal	temporal	ADJ
fnp-6316	328	2	change	change	NOUN
fnp-6316	328	3	of	of	ADP
fnp-6316	328	4	dna	dna	PROPN
fnp-6316	328	5	methylation	methylation	NOUN
fnp-6316	328	6	subclasses	subclass	NOUN
fnp-6316	328	7	between	between	ADP
fnp-6316	328	8	matched	match	VERB
fnp-6316	328	9	newly	newly	ADV
fnp-6316	328	10	diagnosed	diagnose	VERB
fnp-6316	328	11	and	and	CCONJ
fnp-6316	328	12	recurrent	recurrent	ADJ
fnp-6316	328	13	glioblastoma	glioblastoma	NOUN
fnp-6316	328	14	.	.	PUNCT
fnp-6316	329	1	acta	acta	PROPN
fnp-6316	329	2	neuropathol	neuropathol	PROPN
fnp-6316	329	3	.	.	PUNCT
fnp-6316	330	1	2024	2024	NUM
fnp-6316	330	2	jan	jan	PROPN
fnp-6316	330	3	20;147(1):21	20;147(1):21	NUM
fnp-6316	330	4	.	.	PUNCT
fnp-6316	331	1	https://doi.org/10.1007/s00401-023-02677-8	https://doi.org/10.1007/s00401-023-02677-8	NUM
fnp-6316	331	2	14	14	NUM
fnp-6316	331	3	.	.	PUNCT
fnp-6316	332	1	drexler	drexler	PROPN
fnp-6316	332	2	r	r	PROPN
fnp-6316	332	3	,	,	PUNCT
fnp-6316	332	4	ricklefs	ricklefs	PROPN
fnp-6316	332	5	fl	fl	PROPN
fnp-6316	332	6	,	,	PUNCT
fnp-6316	332	7	pantel	pantel	PROPN
fnp-6316	332	8	t	t	PROPN
fnp-6316	332	9	,	,	PUNCT
fnp-6316	332	10	göttsche	göttsche	PROPN
fnp-6316	332	11	j	j	PROPN
fnp-6316	332	12	,	,	PUNCT
fnp-6316	332	13	nitzschke	nitzschke	PROPN
fnp-6316	332	14	r	r	NOUN
fnp-6316	332	15	,	,	PUNCT
fnp-6316	332	16	zöllner	zöllner	NOUN
fnp-6316	332	17	c	c	NOUN
fnp-6316	332	18	,	,	PUNCT
fnp-6316	332	19	westphal	westphal	PROPN
fnp-6316	332	20	m	m	PROPN
fnp-6316	332	21	,	,	PUNCT
fnp-6316	332	22	dührsen	dührsen	PROPN
fnp-6316	332	23	l.	l.	PROPN
fnp-6316	332	24	acta	acta	PROPN
fnp-6316	332	25	neurochir	neurochir	PROPN
fnp-6316	332	26	(	(	PUNCT
fnp-6316	332	27	wien	wien	PROPN
fnp-6316	332	28	)	)	PUNCT
fnp-6316	332	29	.	.	PUNCT
fnp-6316	332	30	2023a	2023a	PROPN
fnp-6316	332	31	aug;165(8):20152027	aug;165(8):20152027	NUM
fnp-6316	332	32	.	.	PUNCT
fnp-6316	333	1	https://doi.org/10.1007/s00701-023-05672-w	https://doi.org/10.1007/s00701-023-05672-w	PROPN
fnp-6316	333	2	15	15	NUM
fnp-6316	333	3	.	.	PUNCT
fnp-6316	334	1	drexler	drexler	PROPN
fnp-6316	334	2	r	r	PROPN
fnp-6316	334	3	,	,	PUNCT
fnp-6316	334	4	schüller	schüller	ADJ
fnp-6316	334	5	u	u	NOUN
fnp-6316	334	6	,	,	PUNCT
fnp-6316	334	7	eckhardt	eckhardt	PROPN
fnp-6316	334	8	a	a	X
fnp-6316	334	9	,	,	PUNCT
fnp-6316	334	10	filipski	filipski	PROPN
fnp-6316	334	11	k	k	PROPN
fnp-6316	334	12	,	,	PUNCT
fnp-6316	334	13	hartung	hartung	PROPN
fnp-6316	334	14	ti	ti	NOUN
fnp-6316	334	15	,	,	PUNCT
fnp-6316	334	16	harter	harter	PROPN
fnp-6316	334	17	pn	pn	PROPN
fnp-6316	334	18	,	,	PUNCT
fnp-6316	334	19	divé	divé	PROPN
fnp-6316	334	20	i	i	PROPN
fnp-6316	334	21	,	,	PUNCT
fnp-6316	334	22	forster	forster	PROPN
fnp-6316	334	23	mt	mt	PROPN
fnp-6316	334	24	,	,	PUNCT
fnp-6316	334	25	czabanka	czabanka	PROPN
fnp-6316	334	26	m	m	PROPN
fnp-6316	334	27	,	,	PUNCT
fnp-6316	334	28	jelgersma	jelgersma	PROPN
fnp-6316	334	29	c	c	PROPN
fnp-6316	334	30	,	,	PUNCT
fnp-6316	334	31	onken	onken	ADJ
fnp-6316	334	32	j	j	NOUN
fnp-6316	334	33	,	,	PUNCT
fnp-6316	334	34	vajkoczy	vajkoczy	PROPN
fnp-6316	334	35	p	p	NOUN
fnp-6316	334	36	,	,	PUNCT
fnp-6316	334	37	capper	capper	NOUN
fnp-6316	334	38	d	d	NOUN
fnp-6316	334	39	,	,	PUNCT
fnp-6316	334	40	siewert	siewert	PROPN
fnp-6316	334	41	c	c	NOUN
fnp-6316	334	42	,	,	PUNCT
fnp-6316	334	43	sauvigny	sauvigny	NOUN
fnp-6316	334	44	t	t	PROPN
fnp-6316	334	45	,	,	PUNCT
fnp-6316	334	46	lamszus	lamszus	PROPN
fnp-6316	334	47	k	k	PROPN
fnp-6316	334	48	,	,	PUNCT
fnp-6316	334	49	westphal	westphal	PROPN
fnp-6316	334	50	m	m	PROPN
fnp-6316	334	51	,	,	PUNCT
fnp-6316	334	52	dührsen	dührsen	ADJ
fnp-6316	334	53	l	l	PROPN
fnp-6316	334	54	,	,	PUNCT
fnp-6316	334	55	ricklefs	ricklefs	PROPN
fnp-6316	334	56	fl	fl	PROPN
fnp-6316	334	57	.	.	PROPN
fnp-6316	334	58	neuro	neuro	PROPN
fnp-6316	334	59	oncol	oncol	PROPN
fnp-6316	334	60	.	.	PUNCT
fnp-6316	335	1	2023b	2023b	PROPN
fnp-6316	335	2	feb	feb	PROPN
fnp-6316	335	3	14;25(2):315	14;25(2):315	PROPN
fnp-6316	335	4	-	-	SYM
fnp-6316	335	5	325	325	NUM
fnp-6316	335	6	.	.	PUNCT
fnp-6316	336	1	https://doi.org/10.1093/neuonc/noac177	https://doi.org/10.1093/neuonc/noac177	X
fnp-6316	336	2	.	.	PUNCT
fnp-6316	337	1	16	16	NUM
fnp-6316	337	2	.	.	PUNCT
fnp-6316	338	1	eckhardt	eckhardt	PROPN
fnp-6316	338	2	a	a	PRON
fnp-6316	338	3	,	,	PUNCT
fnp-6316	338	4	drexler	drexler	NOUN
fnp-6316	338	5	r	r	NOUN
fnp-6316	338	6	,	,	PUNCT
fnp-6316	338	7	schoof	schoof	NOUN
fnp-6316	338	8	m	m	PROPN
fnp-6316	338	9	,	,	PUNCT
fnp-6316	338	10	struve	struve	PROPN
fnp-6316	338	11	n	n	CCONJ
fnp-6316	338	12	,	,	PUNCT
fnp-6316	338	13	capper	capper	NOUN
fnp-6316	338	14	d	d	PROPN
fnp-6316	338	15	,	,	PUNCT
fnp-6316	338	16	jelgersma	jelgersma	PROPN
fnp-6316	338	17	c	c	PROPN
fnp-6316	338	18	,	,	PUNCT
fnp-6316	338	19	onken	onken	ADJ
fnp-6316	338	20	j	j	PROPN
fnp-6316	338	21	,	,	PUNCT
fnp-6316	338	22	harter	harter	PROPN
fnp-6316	338	23	pn	pn	PROPN
fnp-6316	338	24	,	,	PUNCT
fnp-6316	338	25	weber	weber	PROPN
fnp-6316	338	26	kj	kj	PROPN
fnp-6316	338	27	,	,	PUNCT
fnp-6316	338	28	divé	divé	PROPN
fnp-6316	338	29	i	i	PROPN
fnp-6316	338	30	,	,	PUNCT
fnp-6316	338	31	rothkamm	rothkamm	PROPN
fnp-6316	338	32	k	k	PROPN
fnp-6316	338	33	,	,	PUNCT
fnp-6316	338	34	hoffer	hoffer	PROPN
fnp-6316	338	35	k	k	PROPN
fnp-6316	338	36	,	,	PUNCT
fnp-6316	338	37	klumpp	klumpp	PROPN
fnp-6316	338	38	l	l	PROPN
fnp-6316	338	39	,	,	PUNCT
fnp-6316	338	40	ganser	ganser	PROPN
fnp-6316	338	41	k	k	PROPN
fnp-6316	338	42	,	,	PUNCT
fnp-6316	338	43	petersen	petersen	PROPN
fnp-6316	338	44	c	c	PROPN
fnp-6316	338	45	,	,	PUNCT
fnp-6316	338	46	ricklefs	ricklefs	PROPN
fnp-6316	338	47	f	f	NUM
fnp-6316	338	48	,	,	PUNCT
fnp-6316	338	49	kriegs	kriegs	PROPN
fnp-6316	338	50	m	m	PRON
fnp-6316	338	51	,	,	PUNCT
fnp-6316	338	52	schüller	schüller	ADJ
fnp-6316	338	53	u.	u.	NOUN
fnp-6316	338	54	mean	mean	PROPN
fnp-6316	338	55	global	global	ADJ
fnp-6316	338	56	dna	dna	PROPN
fnp-6316	338	57	methylation	methylation	NOUN
fnp-6316	338	58	serves	serve	VERB
fnp-6316	338	59	as	as	ADP
fnp-6316	338	60	independent	independent	ADJ
fnp-6316	338	61	prognostic	prognostic	ADJ
fnp-6316	338	62	marker	marker	NOUN
fnp-6316	338	63	in	in	ADP
fnp-6316	338	64	idh	idh	NOUN
fnp-6316	338	65	-	-	PUNCT
fnp-6316	338	66	wildtype	wildtype	NOUN
fnp-6316	338	67	glioblastoma	glioblastoma	NOUN
fnp-6316	338	68	.	.	PUNCT
fnp-6316	339	1	neuro	neuro	PROPN
fnp-6316	339	2	oncol	oncol	PROPN
fnp-6316	339	3	.	.	PUNCT
fnp-6316	340	1	2024	2024	NUM
fnp-6316	340	2	mar	mar	PROPN
fnp-6316	340	3	4;26(3):503	4;26(3):503	NUM
fnp-6316	340	4	-	-	PUNCT
fnp-6316	340	5	513	513	NUM
fnp-6316	340	6	.	.	PUNCT
fnp-6316	340	7	https://doi.org/10.1093/neuonc/noad197	https://doi.org/10.1093/neuonc/noad197	NOUN
fnp-6316	340	8	17	17	NUM
fnp-6316	340	9	.	.	PUNCT
fnp-6316	340	10	emiliani	emiliani	PROPN
fnp-6316	340	11	fe	fe	PROPN
fnp-6316	340	12	,	,	PUNCT
fnp-6316	340	13	ismail	ismail	PROPN
fnp-6316	340	14	aao	aao	PROPN
fnp-6316	340	15	,	,	PUNCT
fnp-6316	340	16	hughes	hughes	PROPN
fnp-6316	340	17	eg	eg	PROPN
fnp-6316	340	18	,	,	PUNCT
fnp-6316	340	19	tsongalis	tsongalis	PROPN
fnp-6316	340	20	gj	gj	NOUN
fnp-6316	340	21	,	,	PUNCT
fnp-6316	340	22	zanazzi	zanazzi	NOUN
fnp-6316	340	23	gj	gj	PROPN
fnp-6316	340	24	,	,	PUNCT
fnp-6316	340	25	lin	lin	PROPN
fnp-6316	340	26	cc	cc	PROPN
fnp-6316	340	27	.	.	PROPN
fnp-6316	340	28	nanopore	nanopore	ADV
fnp-6316	340	29	-	-	PUNCT
fnp-6316	340	30	based	base	VERB
fnp-6316	340	31	random	random	ADJ
fnp-6316	340	32	genomic	genomic	NOUN
fnp-6316	340	33	sampling	sampling	NOUN
fnp-6316	340	34	for	for	ADP
fnp-6316	340	35	intraoperative	intraoperative	ADJ
fnp-6316	340	36	molecular	molecular	ADJ
fnp-6316	340	37	diagnosis	diagnosis	NOUN
fnp-6316	340	38	.	.	PUNCT
fnp-6316	341	1	genome	genome	NOUN
fnp-6316	341	2	med	me	VERB
fnp-6316	341	3	.	.	PUNCT
fnp-6316	342	1	2025	2025	NUM
fnp-6316	342	2	jan	jan	PROPN
fnp-6316	342	3	20;17(1):6	20;17(1):6	NUM
fnp-6316	342	4	.	.	PUNCT
fnp-6316	343	1	https://doi.org/10.1186/s13073-025-01427-7	https://doi.org/10.1186/s13073-025-01427-7	NUM
fnp-6316	343	2	18	18	NUM
fnp-6316	343	3	.	.	PUNCT
fnp-6316	343	4	farrelly	farrelly	PROPN
fnp-6316	343	5	la	la	PROPN
fnp-6316	343	6	,	,	PUNCT
fnp-6316	343	7	thompson	thompson	PROPN
fnp-6316	343	8	re	re	NOUN
fnp-6316	343	9	,	,	PUNCT
fnp-6316	343	10	zhao	zhao	PROPN
fnp-6316	343	11	s	s	PROPN
fnp-6316	343	12	,	,	PUNCT
fnp-6316	343	13	lepack	lepack	PROPN
fnp-6316	343	14	ae	ae	PROPN
fnp-6316	343	15	,	,	PUNCT
fnp-6316	343	16	lyu	lyu	VERB
fnp-6316	343	17	y	y	PROPN
fnp-6316	343	18	,	,	PUNCT
fnp-6316	343	19	bhanu	bhanu	PROPN
fnp-6316	343	20	nv	nv	PROPN
fnp-6316	343	21	,	,	PUNCT
fnp-6316	343	22	zhang	zhang	PROPN
fnp-6316	343	23	b	b	PROPN
fnp-6316	343	24	,	,	PUNCT
fnp-6316	343	25	loh	loh	PROPN
fnp-6316	343	26	ye	ye	NOUN
fnp-6316	343	27	,	,	PUNCT
fnp-6316	343	28	ramakrishnan	ramakrishnan	VERB
fnp-6316	343	29	a	a	PRON
fnp-6316	343	30	,	,	PUNCT
fnp-6316	343	31	vadodaria	vadodaria	PROPN
fnp-6316	343	32	kc	kc	PROPN
fnp-6316	343	33	,	,	PUNCT
fnp-6316	343	34	heard	hear	VERB
fnp-6316	343	35	kj	kj	PROPN
fnp-6316	343	36	,	,	PUNCT
fnp-6316	343	37	erikson	erikson	PROPN
fnp-6316	343	38	g	g	PROPN
fnp-6316	343	39	,	,	PUNCT
fnp-6316	343	40	nakadai	nakadai	PROPN
fnp-6316	343	41	t	t	PROPN
fnp-6316	343	42	,	,	PUNCT
fnp-6316	343	43	bastle	bastle	PROPN
fnp-6316	343	44	rm	rm	PROPN
fnp-6316	343	45	,	,	PUNCT
fnp-6316	343	46	lukasak	lukasak	PROPN
fnp-6316	343	47	bj	bj	VERB
fnp-6316	343	48	,	,	PUNCT
fnp-6316	343	49	zebroski	zebroski	PROPN
fnp-6316	343	50	h	h	NOUN
fnp-6316	343	51	3rd	3rd	NOUN
fnp-6316	343	52	,	,	PUNCT
fnp-6316	343	53	alenina	alenina	NOUN
fnp-6316	343	54	n	n	PRON
fnp-6316	343	55	,	,	PUNCT
fnp-6316	343	56	bader	bader	PROPN
fnp-6316	343	57	m	m	PROPN
fnp-6316	343	58	,	,	PUNCT
fnp-6316	343	59	berton	berton	PROPN
fnp-6316	343	60	o	o	NOUN
fnp-6316	343	61	,	,	PUNCT
fnp-6316	343	62	roeder	roeder	PROPN
fnp-6316	343	63	rg	rg	PROPN
fnp-6316	343	64	,	,	PUNCT
fnp-6316	343	65	molina	molina	PROPN
fnp-6316	343	66	h	h	PROPN
fnp-6316	343	67	,	,	PUNCT
fnp-6316	343	68	gage	gage	PROPN
fnp-6316	343	69	fh	fh	PROPN
fnp-6316	343	70	,	,	PUNCT
fnp-6316	343	71	shen	shen	PROPN
fnp-6316	343	72	l	l	PROPN
fnp-6316	343	73	,	,	PUNCT
fnp-6316	343	74	garcia	garcia	PROPN
fnp-6316	343	75	ba	ba	PROPN
fnp-6316	343	76	,	,	PUNCT
fnp-6316	343	77	li	li	PROPN
fnp-6316	343	78	h	h	PROPN
fnp-6316	343	79	,	,	PUNCT
fnp-6316	343	80	muir	muir	PROPN
fnp-6316	343	81	tw	tw	PROPN
fnp-6316	343	82	,	,	PUNCT
fnp-6316	343	83	maze	maze	NOUN
fnp-6316	343	84	i.	i.	NOUN
fnp-6316	343	85	nature	nature	PROPN
fnp-6316	343	86	.	.	PUNCT
fnp-6316	344	1	2019	2019	NUM
fnp-6316	344	2	mar;567(7749):535	mar;567(7749):535	PROPN
fnp-6316	344	3	-	-	PUNCT
fnp-6316	344	4	539	539	NUM
fnp-6316	344	5	.	.	PUNCT
fnp-6316	345	1	https://doi.org/10.1038/s41586-019-1024-7	https://doi.org/10.1038/s41586-019-1024-7	PROPN
fnp-6316	345	2	19	19	NUM
fnp-6316	345	3	.	.	PUNCT
fnp-6316	345	4	harms	harm	VERB
fnp-6316	345	5	jwa	jwa	PROPN
fnp-6316	345	6	,	,	PUNCT
fnp-6316	345	7	streckert	streckert	ADJ
fnp-6316	345	8	ems	ems	PROPN
fnp-6316	345	9	,	,	PUNCT
fnp-6316	345	10	kiolbassa	kiolbassa	PROPN
fnp-6316	345	11	nm	nm	PROPN
fnp-6316	345	12	,	,	PUNCT
fnp-6316	345	13	thomas	thomas	PROPN
fnp-6316	345	14	c	c	PROPN
fnp-6316	345	15	,	,	PUNCT
fnp-6316	345	16	grauer	grauer	PROPN
fnp-6316	345	17	o	o	PROPN
fnp-6316	345	18	,	,	PUNCT
fnp-6316	345	19	oertel	oertel	PROPN
fnp-6316	345	20	m	m	PROPN
fnp-6316	345	21	,	,	PUNCT
fnp-6316	345	22	eich	eich	PROPN
fnp-6316	345	23	ht	ht	PROPN
fnp-6316	345	24	,	,	PUNCT
fnp-6316	345	25	stummer	stummer	PROPN
fnp-6316	345	26	w	w	PROPN
fnp-6316	345	27	,	,	PUNCT
fnp-6316	345	28	paulus	paulus	PROPN
fnp-6316	345	29	w	w	PROPN
fnp-6316	345	30	,	,	PUNCT
fnp-6316	345	31	brokinkel	brokinkel	PROPN
fnp-6316	345	32	b.	b.	PROPN
fnp-6316	345	33	confounders	confounder	NOUN
fnp-6316	345	34	of	of	ADP
fnp-6316	345	35	intraoperative	intraoperative	ADJ
fnp-6316	345	36	frozen	frozen	ADJ
fnp-6316	345	37	section	section	NOUN
fnp-6316	345	38	pathology	pathology	NOUN
fnp-6316	345	39	during	during	ADP
fnp-6316	345	40	glioma	glioma	NOUN
fnp-6316	345	41	surgery	surgery	NOUN
fnp-6316	345	42	.	.	PUNCT
fnp-6316	346	1	neurosurg	neurosurg	PROPN
fnp-6316	346	2	rev	rev	PROPN
fnp-6316	346	3	.	.	PROPN
fnp-6316	346	4	2023	2023	NUM
fnp-6316	346	5	oct	oct	PROPN
fnp-6316	346	6	28;46(1):286	28;46(1):286	NUM
fnp-6316	346	7	.	.	PUNCT
fnp-6316	347	1	https://doi.org/10.1007/s10143-023-02169-z	https://doi.org/10.1007/s10143-023-02169-z	PROPN
fnp-6316	347	2	20	20	NUM
fnp-6316	347	3	.	.	PUNCT
fnp-6316	348	1	hickman	hickman	PROPN
fnp-6316	348	2	ra	ra	PROPN
fnp-6316	348	3	,	,	PUNCT
fnp-6316	348	4	miller	miller	PROPN
fnp-6316	348	5	am	am	PROPN
fnp-6316	348	6	,	,	PUNCT
fnp-6316	348	7	holle	holle	PROPN
fnp-6316	348	8	bm	bm	PROPN
fnp-6316	348	9	,	,	PUNCT
fnp-6316	348	10	jee	jee	PROPN
fnp-6316	348	11	j	j	PROPN
fnp-6316	348	12	,	,	PUNCT
fnp-6316	348	13	liu	liu	PROPN
fnp-6316	348	14	sy	sy	PROPN
fnp-6316	348	15	,	,	PUNCT
fnp-6316	348	16	ross	ross	PROPN
fnp-6316	348	17	d	d	PROPN
fnp-6316	348	18	,	,	PUNCT
fnp-6316	348	19	yu	yu	PROPN
fnp-6316	348	20	h	h	NOUN
fnp-6316	348	21	,	,	PUNCT
fnp-6316	348	22	riely	riely	ADJ
fnp-6316	348	23	gj	gj	NOUN
fnp-6316	348	24	,	,	PUNCT
fnp-6316	348	25	ombres	ombre	NOUN
fnp-6316	348	26	c	c	VERB
fnp-6316	348	27	,	,	PUNCT
fnp-6316	348	28	gewirtz	gewirtz	PROPN
fnp-6316	348	29	an	an	NOUN
fnp-6316	348	30	,	,	PUNCT
fnp-6316	348	31	reiner	reiner	NOUN
fnp-6316	348	32	as	as	ADP
fnp-6316	348	33	,	,	PUNCT
fnp-6316	348	34	nandakumar	nandakumar	PROPN
fnp-6316	348	35	s	s	PROPN
fnp-6316	348	36	,	,	PUNCT
fnp-6316	348	37	price	price	NOUN
fnp-6316	348	38	a	a	PRON
fnp-6316	348	39	,	,	PUNCT
fnp-6316	348	40	kaley	kaley	PROPN
fnp-6316	348	41	tj	tj	PROPN
fnp-6316	348	42	,	,	PUNCT
fnp-6316	348	43	graham	graham	PROPN
fnp-6316	348	44	ms	ms	PROPN
fnp-6316	348	45	,	,	PUNCT
fnp-6316	348	46	vanderbilt	vanderbilt	PROPN
fnp-6316	348	47	c	c	PROPN
fnp-6316	348	48	,	,	PUNCT
fnp-6316	348	49	rana	rana	PROPN
fnp-6316	348	50	s	s	PROPN
fnp-6316	348	51	,	,	PUNCT
fnp-6316	348	52	hill	hill	PROPN
fnp-6316	348	53	k	k	PROPN
fnp-6316	348	54	,	,	PUNCT
fnp-6316	348	55	chabot	chabot	PROPN
fnp-6316	348	56	k	k	PROPN
fnp-6316	348	57	,	,	PUNCT
fnp-6316	348	58	campos	campos	PROPN
fnp-6316	348	59	c	c	PROPN
fnp-6316	348	60	,	,	PUNCT
fnp-6316	348	61	nafa	nafa	PROPN
fnp-6316	348	62	k	k	PROPN
fnp-6316	348	63	,	,	PUNCT
fnp-6316	348	64	shukla	shukla	PROPN
fnp-6316	348	65	n	n	PRON
fnp-6316	348	66	,	,	PUNCT
fnp-6316	348	67	karajannis	karajannis	PROPN
fnp-6316	348	68	m	m	PROPN
fnp-6316	348	69	,	,	PUNCT
fnp-6316	348	70	li	li	PROPN
fnp-6316	348	71	b	b	PROPN
fnp-6316	348	72	,	,	PUNCT
fnp-6316	348	73	berger	berger	PROPN
fnp-6316	348	74	m	m	PROPN
fnp-6316	348	75	,	,	PUNCT
fnp-6316	348	76	ladanyi	ladanyi	PROPN
fnp-6316	348	77	m	m	PROPN
fnp-6316	348	78	,	,	PUNCT
fnp-6316	348	79	pentsova	pentsova	PROPN
fnp-6316	348	80	e	e	PROPN
fnp-6316	348	81	,	,	PUNCT
fnp-6316	348	82	boire	boire	X
fnp-6316	348	83	a	a	X
fnp-6316	348	84	,	,	PUNCT
fnp-6316	348	85	brannon	brannon	PROPN
fnp-6316	348	86	ar	ar	PROPN
fnp-6316	348	87	,	,	PUNCT
fnp-6316	348	88	bale	bale	NOUN
fnp-6316	348	89	t	t	PROPN
fnp-6316	348	90	,	,	PUNCT
fnp-6316	348	91	mellinghoff	mellinghoff	NOUN
fnp-6316	348	92	ik	ik	PROPN
fnp-6316	348	93	,	,	PUNCT
fnp-6316	348	94	arcila	arcila	VERB
fnp-6316	348	95	me	i	PRON
fnp-6316	348	96	.	.	PUNCT
fnp-6316	349	1	real	real	ADJ
fnp-6316	349	2	-	-	PUNCT
fnp-6316	349	3	world	world	NOUN
fnp-6316	349	4	experience	experience	NOUN
fnp-6316	349	5	with	with	ADP
fnp-6316	349	6	circulating	circulate	VERB
fnp-6316	349	7	tumor	tumor	NOUN
fnp-6316	349	8	dna	dna	NOUN
fnp-6316	349	9	in	in	ADP
fnp-6316	349	10	cerebrospinal	cerebrospinal	ADJ
fnp-6316	349	11	fluid	fluid	NOUN
fnp-6316	349	12	from	from	ADP
fnp-6316	349	13	patients	patient	NOUN
fnp-6316	349	14	with	with	ADP
fnp-6316	349	15	central	central	ADJ
fnp-6316	349	16	nervous	nervous	ADJ
fnp-6316	349	17	system	system	NOUN
fnp-6316	349	18	tumors	tumor	NOUN
fnp-6316	349	19	.	.	PUNCT
fnp-6316	350	1	acta	acta	PROPN
fnp-6316	350	2	neuropathol	neuropathol	PROPN
fnp-6316	350	3	commun	commun	PROPN
fnp-6316	350	4	.	.	PUNCT
fnp-6316	351	1	2024	2024	NUM
fnp-6316	351	2	sep	sep	PROPN
fnp-6316	351	3	17;12(1):151	17;12(1):151	NUM
fnp-6316	351	4	.	.	PUNCT
fnp-6316	351	5	https://doi.org/10.1186/s40478-024-01846-4	https://doi.org/10.1186/s40478-024-01846-4	NUM
fnp-6316	351	6	21	21	NUM
fnp-6316	351	7	.	.	PUNCT
fnp-6316	352	1	kienast	kienast	PROPN
fnp-6316	352	2	y	y	PROPN
fnp-6316	352	3	,	,	PUNCT
fnp-6316	352	4	von	von	PROPN
fnp-6316	352	5	baumgarten	baumgarten	VERB
fnp-6316	352	6	l	l	PROPN
fnp-6316	352	7	,	,	PUNCT
fnp-6316	352	8	fuhrmann	fuhrmann	PROPN
fnp-6316	352	9	m	m	PROPN
fnp-6316	352	10	,	,	PUNCT
fnp-6316	352	11	klinkert	klinkert	PROPN
fnp-6316	352	12	we	we	PRON
fnp-6316	352	13	,	,	PUNCT
fnp-6316	352	14	goldbrunner	goldbrunner	NOUN
fnp-6316	352	15	r	r	NOUN
fnp-6316	352	16	,	,	PUNCT
fnp-6316	352	17	herms	herms	PROPN
fnp-6316	352	18	j	j	PROPN
fnp-6316	352	19	,	,	PUNCT
fnp-6316	352	20	winkler	winkler	PROPN
fnp-6316	352	21	f.	f.	PROPN
fnp-6316	352	22	real	real	ADJ
fnp-6316	352	23	-	-	PUNCT
fnp-6316	352	24	time	time	NOUN
fnp-6316	352	25	imaging	imaging	NOUN
fnp-6316	352	26	reveals	reveal	VERB
fnp-6316	352	27	the	the	DET
fnp-6316	352	28	single	single	ADJ
fnp-6316	352	29	steps	step	NOUN
fnp-6316	352	30	of	of	ADP
fnp-6316	352	31	brain	brain	NOUN
fnp-6316	352	32	metastasis	metastasis	NOUN
fnp-6316	352	33	formation	formation	NOUN
fnp-6316	352	34	.	.	PUNCT
fnp-6316	353	1	nat	nat	PROPN
fnp-6316	353	2	med	med	PROPN
fnp-6316	353	3	.	.	PUNCT
fnp-6316	354	1	2010	2010	NUM
fnp-6316	354	2	jan;16(1):116	jan;16(1):116	PROPN
fnp-6316	354	3	-	-	PUNCT
fnp-6316	354	4	22	22	NUM
fnp-6316	354	5	.	.	PUNCT
fnp-6316	355	1	https://doi.org/10.1038/nm.2072	https://doi.org/10.1038/nm.2072	NOUN
fnp-6316	355	2	22	22	NUM
fnp-6316	355	3	.	.	PUNCT
fnp-6316	356	1	kirishima	kirishima	PROPN
fnp-6316	356	2	m	m	PROPN
fnp-6316	356	3	,	,	PUNCT
fnp-6316	356	4	yokoyama	yokoyama	PROPN
fnp-6316	356	5	s	s	PROPN
fnp-6316	356	6	,	,	PUNCT
fnp-6316	356	7	akahane	akahane	PROPN
fnp-6316	356	8	t	t	PROPN
fnp-6316	356	9	,	,	PUNCT
fnp-6316	356	10	higa	higa	PROPN
fnp-6316	356	11	n	n	CCONJ
fnp-6316	356	12	,	,	PUNCT
fnp-6316	356	13	uchida	uchida	PROPN
fnp-6316	356	14	h	h	PROPN
fnp-6316	356	15	,	,	PUNCT
fnp-6316	356	16	yonezawa	yonezawa	PROPN
fnp-6316	356	17	h	h	PROPN
fnp-6316	356	18	,	,	PUNCT
fnp-6316	356	19	matsuo	matsuo	PROPN
fnp-6316	356	20	k	k	PROPN
fnp-6316	356	21	,	,	PUNCT
fnp-6316	356	22	yamamoto	yamamoto	PROPN
fnp-6316	356	23	j	j	PROPN
fnp-6316	356	24	,	,	PUNCT
fnp-6316	356	25	yoshimoto	yoshimoto	PROPN
fnp-6316	356	26	k	k	PROPN
fnp-6316	356	27	,	,	PUNCT
fnp-6316	356	28	hanaya	hanaya	NOUN
fnp-6316	356	29	r	r	NOUN
fnp-6316	356	30	,	,	PUNCT
fnp-6316	356	31	tanimoto	tanimoto	NOUN
fnp-6316	356	32	a.	a.	NOUN
fnp-6316	356	33	prognosis	prognosis	PROPN
fnp-6316	356	34	prediction	prediction	NOUN
fnp-6316	356	35	via	via	ADP
fnp-6316	356	36	histological	histological	ADJ
fnp-6316	356	37	evaluation	evaluation	NOUN
fnp-6316	356	38	of	of	ADP
fnp-6316	356	39	cellular	cellular	ADJ
fnp-6316	356	40	heterogeneity	heterogeneity	NOUN
fnp-6316	356	41	in	in	ADP
fnp-6316	356	42	glioblastoma	glioblastoma	NOUN
fnp-6316	356	43	.	.	PUNCT
fnp-6316	357	1	sci	sci	PROPN
fnp-6316	357	2	rep	rep	PROPN
fnp-6316	357	3	.	.	PROPN
fnp-6316	357	4	2024	2024	NUM
fnp-6316	357	5	oct	oct	PROPN
fnp-6316	357	6	23;14(1):24955	23;14(1):24955	NUM
fnp-6316	357	7	.	.	PUNCT
fnp-6316	358	1	https://doi.org/10.1038/s41598-024-76826-8	https://doi.org/10.1038/s41598-024-76826-8	PROPN
fnp-6316	358	2	23	23	NUM
fnp-6316	358	3	.	.	PUNCT
fnp-6316	359	1	kirschenbaum	kirschenbaum	PROPN
fnp-6316	359	2	d	d	PROPN
fnp-6316	359	3	,	,	PUNCT
fnp-6316	359	4	xie	xie	PROPN
fnp-6316	360	1	k	k	PROPN
fnp-6316	360	2	,	,	PUNCT
fnp-6316	360	3	ingelfinger	ingelfinger	ADJ
fnp-6316	360	4	f	f	PROPN
fnp-6316	360	5	,	,	PUNCT
fnp-6316	360	6	katzenelenbogen	katzenelenbogen	PROPN
fnp-6316	360	7	y	y	PROPN
fnp-6316	360	8	,	,	PUNCT
fnp-6316	360	9	abadie	abadie	VERB
fnp-6316	360	10	k	k	NOUN
fnp-6316	360	11	,	,	PUNCT
fnp-6316	360	12	look	look	VERB
fnp-6316	360	13	t	t	PROPN
fnp-6316	360	14	,	,	PUNCT
fnp-6316	360	15	sheban	sheban	ADJ
fnp-6316	360	16	f	f	PROPN
fnp-6316	360	17	,	,	PUNCT
fnp-6316	360	18	phan	phan	PROPN
fnp-6316	360	19	ts	ts	PROPN
fnp-6316	360	20	,	,	PUNCT
fnp-6316	360	21	li	li	PROPN
fnp-6316	360	22	b	b	PROPN
fnp-6316	360	23	,	,	PUNCT
fnp-6316	360	24	zwicky	zwicky	PROPN
fnp-6316	360	25	p	p	NOUN
fnp-6316	360	26	,	,	PUNCT
fnp-6316	360	27	yofe	yofe	NOUN
fnp-6316	360	28	i	i	PRON
fnp-6316	360	29	,	,	PUNCT
fnp-6316	360	30	david	david	PROPN
fnp-6316	360	31	e	e	PROPN
fnp-6316	360	32	,	,	PUNCT
fnp-6316	360	33	mazuz	mazuz	PROPN
fnp-6316	360	34	k	k	PROPN
fnp-6316	360	35	,	,	PUNCT
fnp-6316	360	36	hou	hou	PROPN
fnp-6316	360	37	j	j	PROPN
fnp-6316	360	38	,	,	PUNCT
fnp-6316	360	39	chen	chen	PROPN
fnp-6316	360	40	y	y	PROPN
fnp-6316	360	41	,	,	PUNCT
fnp-6316	360	42	shaim	shaim	VERB
fnp-6316	360	43	h	h	PROPN
fnp-6316	360	44	,	,	PUNCT
fnp-6316	360	45	shanley	shanley	PROPN
fnp-6316	360	46	m	m	PROPN
fnp-6316	360	47	,	,	PUNCT
fnp-6316	360	48	becker	becker	PROPN
fnp-6316	360	49	s	s	PART
fnp-6316	360	50	,	,	PUNCT
fnp-6316	360	51	qian	qian	PROPN
fnp-6316	360	52	j	j	PROPN
fnp-6316	360	53	,	,	PUNCT
fnp-6316	360	54	colonna	colonna	NOUN
fnp-6316	360	55	m	m	NOUN
fnp-6316	360	56	,	,	PUNCT
fnp-6316	360	57	ginhoux	ginhoux	VERB
fnp-6316	360	58	f	f	PROPN
fnp-6316	360	59	,	,	PUNCT
fnp-6316	360	60	rezvani	rezvani	PROPN
fnp-6316	360	61	k	k	PROPN
fnp-6316	360	62	,	,	PUNCT
fnp-6316	360	63	theis	theis	PROPN
fnp-6316	360	64	fj	fj	PROPN
fnp-6316	360	65	,	,	PUNCT
fnp-6316	360	66	yosef	yosef	PROPN
fnp-6316	360	67	n	n	CCONJ
fnp-6316	360	68	,	,	PUNCT
fnp-6316	360	69	weiss	weiss	PROPN
fnp-6316	360	70	t	t	PROPN
fnp-6316	360	71	,	,	PUNCT
fnp-6316	360	72	weiner	weiner	NOUN
fnp-6316	360	73	a	a	PRON
fnp-6316	360	74	,	,	PUNCT
fnp-6316	360	75	amit	amit	PROPN
fnp-6316	360	76	i.	i.	PROPN
fnp-6316	360	77	time	time	PROPN
fnp-6316	360	78	-	-	PUNCT
fnp-6316	360	79	resolved	resolve	VERB
fnp-6316	360	80	single	single	ADJ
fnp-6316	360	81	-	-	PUNCT
fnp-6316	360	82	cell	cell	NOUN
fnp-6316	360	83	transcriptomics	transcriptomic	NOUN
fnp-6316	360	84	defines	define	VERB
fnp-6316	360	85	immune	immune	ADJ
fnp-6316	360	86	trajectories	trajectory	NOUN
fnp-6316	360	87	in	in	ADP
fnp-6316	360	88	glioblastoma	glioblastoma	NOUN
fnp-6316	360	89	.	.	PUNCT
fnp-6316	361	1	cell	cell	NOUN
fnp-6316	361	2	.	.	PUNCT
fnp-6316	362	1	2024	2024	NUM
fnp-6316	362	2	jan	jan	PROPN
fnp-6316	362	3	4;187(1):149	4;187(1):149	PROPN
fnp-6316	362	4	-	-	PUNCT
fnp-6316	362	5	165.e23	165.e23	NUM
fnp-6316	362	6	.	.	PUNCT
fnp-6316	363	1	https://doi.org/10.1016/j.cell.2023.11.032	https://doi.org/10.1016/j.cell.2023.11.032	NUM
fnp-6316	363	2	24	24	NUM
fnp-6316	363	3	.	.	PUNCT
fnp-6316	363	4	kovalchuk	kovalchuk	PROPN
fnp-6316	363	5	b	b	PROPN
fnp-6316	363	6	,	,	PUNCT
fnp-6316	363	7	berghoff	berghoff	INTJ
fnp-6316	363	8	as	as	ADP
fnp-6316	363	9	,	,	PUNCT
fnp-6316	363	10	karreman	karreman	PROPN
fnp-6316	363	11	ma	ma	PROPN
fnp-6316	363	12	,	,	PUNCT
fnp-6316	363	13	frey	frey	PROPN
fnp-6316	363	14	k	k	PROPN
fnp-6316	363	15	,	,	PUNCT
fnp-6316	363	16	piechutta	piechutta	PROPN
fnp-6316	363	17	m	m	PROPN
fnp-6316	363	18	,	,	PUNCT
fnp-6316	363	19	fischer	fischer	PROPN
fnp-6316	363	20	m	m	PROPN
fnp-6316	363	21	,	,	PUNCT
fnp-6316	363	22	grosch	grosch	PROPN
fnp-6316	363	23	j	j	PROPN
fnp-6316	363	24	,	,	PUNCT
fnp-6316	363	25	heiland	heiland	PROPN
fnp-6316	363	26	s	s	PROPN
fnp-6316	363	27	,	,	PUNCT
fnp-6316	363	28	breckwoldt	breckwoldt	PROPN
fnp-6316	363	29	mo	mo	PROPN
fnp-6316	363	30	,	,	PUNCT
fnp-6316	363	31	hilberg	hilberg	PROPN
fnp-6316	363	32	f	f	PROPN
fnp-6316	363	33	,	,	PUNCT
fnp-6316	363	34	wick	wick	VERB
fnp-6316	363	35	w	w	PROPN
fnp-6316	363	36	,	,	PUNCT
fnp-6316	363	37	winkler	winkler	PROPN
fnp-6316	363	38	f.	f.	PROPN
fnp-6316	363	39	nintedanib	nintedanib	PROPN
fnp-6316	363	40	and	and	CCONJ
fnp-6316	363	41	a	a	DET
fnp-6316	363	42	bi	bi	ADJ
fnp-6316	363	43	-	-	ADJ
fnp-6316	363	44	specific	specific	ADJ
fnp-6316	363	45	anti	anti	ADJ
fnp-6316	363	46	-	-	NOUN
fnp-6316	363	47	vegf	vegf	ADJ
fnp-6316	363	48	/	/	SYM
fnp-6316	363	49	ang2	ang2	PROPN
fnp-6316	363	50	nanobody	nanobody	NOUN
fnp-6316	363	51	selectively	selectively	ADV
fnp-6316	363	52	prevent	prevent	VERB
fnp-6316	363	53	brain	brain	NOUN
fnp-6316	363	54	metastases	metastasis	NOUN
fnp-6316	363	55	of	of	ADP
fnp-6316	363	56	lung	lung	NOUN
fnp-6316	363	57	adenocarcinoma	adenocarcinoma	NOUN
fnp-6316	363	58	cells	cell	NOUN
fnp-6316	363	59	.	.	PUNCT
fnp-6316	364	1	clin	clin	PROPN
fnp-6316	364	2	exp	exp	NOUN
fnp-6316	364	3	metastasis	metastasis	NOUN
fnp-6316	364	4	.	.	PUNCT
fnp-6316	365	1	2020	2020	NUM
fnp-6316	365	2	dec;37(6):637	dec;37(6):637	PROPN
fnp-6316	365	3	-	-	PUNCT
fnp-6316	365	4	648	648	NUM
fnp-6316	365	5	.	.	PUNCT
fnp-6316	366	1	https://doi.org/10.1007/s10585-020-10055-x	https://doi.org/10.1007/s10585-020-10055-x	PROPN
fnp-6316	366	2	25	25	NUM
fnp-6316	366	3	.	.	PUNCT
fnp-6316	367	1	liu	liu	PROPN
fnp-6316	367	2	apy	apy	PROPN
fnp-6316	367	3	,	,	PUNCT
fnp-6316	367	4	smith	smith	PROPN
fnp-6316	367	5	ks	ks	PROPN
fnp-6316	367	6	,	,	PUNCT
fnp-6316	367	7	kumar	kumar	PROPN
fnp-6316	367	8	r	r	PROPN
fnp-6316	367	9	,	,	PUNCT
fnp-6316	367	10	paul	paul	PROPN
fnp-6316	367	11	l	l	PROPN
fnp-6316	367	12	,	,	PUNCT
fnp-6316	367	13	bihannic	bihannic	ADJ
fnp-6316	367	14	l	l	PROPN
fnp-6316	367	15	,	,	PUNCT
fnp-6316	367	16	lin	lin	PROPN
fnp-6316	367	17	t	t	PROPN
fnp-6316	367	18	,	,	PUNCT
fnp-6316	367	19	maass	maass	PROPN
fnp-6316	367	20	kk	kk	PROPN
fnp-6316	367	21	,	,	PUNCT
fnp-6316	367	22	pajtler	pajtler	ADJ
fnp-6316	367	23	kw	kw	PROPN
fnp-6316	367	24	,	,	PUNCT
fnp-6316	367	25	chintagumpala	chintagumpala	PROPN
fnp-6316	367	26	m	m	PROPN
fnp-6316	367	27	,	,	PUNCT
fnp-6316	367	28	su	su	PROPN
fnp-6316	367	29	jm	jm	PROPN
fnp-6316	367	30	,	,	PUNCT
fnp-6316	367	31	bouffet	bouffet	VERB
fnp-6316	367	32	e	e	NOUN
fnp-6316	367	33	,	,	PUNCT
fnp-6316	367	34	fisher	fisher	PROPN
fnp-6316	367	35	mj	mj	PROPN
fnp-6316	367	36	,	,	PUNCT
fnp-6316	367	37	gururangan	gururangan	VERB
fnp-6316	367	38	s	s	PROPN
fnp-6316	367	39	,	,	PUNCT
fnp-6316	367	40	cohn	cohn	PROPN
fnp-6316	367	41	r	r	PROPN
fnp-6316	367	42	,	,	PUNCT
fnp-6316	367	43	hassall	hassall	PROPN
fnp-6316	367	44	t	t	PROPN
fnp-6316	367	45	,	,	PUNCT
fnp-6316	367	46	hansford	hansford	PROPN
fnp-6316	367	47	jr	jr	PROPN
fnp-6316	367	48	,	,	PUNCT
fnp-6316	367	49	klimo	klimo	PROPN
fnp-6316	367	50	p	p	PROPN
fnp-6316	367	51	jr	jr	PROPN
fnp-6316	367	52	,	,	PUNCT
fnp-6316	367	53	boop	boop	PROPN
fnp-6316	367	54	fa	fa	PROPN
fnp-6316	367	55	,	,	PUNCT
fnp-6316	367	56	stewart	stewart	PROPN
fnp-6316	367	57	cf	cf	PROPN
fnp-6316	367	58	,	,	PUNCT
fnp-6316	367	59	harreld	harreld	PROPN
fnp-6316	367	60	jh	jh	PROPN
fnp-6316	367	61	,	,	PUNCT
fnp-6316	367	62	merchant	merchant	NOUN
fnp-6316	367	63	te	te	PROPN
fnp-6316	367	64	,	,	PUNCT
fnp-6316	367	65	tatevossian	tatevossian	PROPN
fnp-6316	367	66	rg	rg	PROPN
fnp-6316	367	67	,	,	PUNCT
fnp-6316	367	68	neale	neale	PROPN
fnp-6316	367	69	g	g	PROPN
fnp-6316	367	70	,	,	PUNCT
fnp-6316	367	71	lear	lear	PROPN
fnp-6316	367	72	m	m	PROPN
fnp-6316	367	73	,	,	PUNCT
fnp-6316	367	74	klco	klco	PROPN
fnp-6316	367	75	jm	jm	PROPN
fnp-6316	367	76	,	,	PUNCT
fnp-6316	367	77	orr	orr	PROPN
fnp-6316	367	78	ba	ba	PROPN
fnp-6316	367	79	,	,	PUNCT
fnp-6316	367	80	ellison	ellison	PROPN
fnp-6316	367	81	dw	dw	PROPN
fnp-6316	367	82	,	,	PUNCT
fnp-6316	367	83	gilbertson	gilbertson	PROPN
fnp-6316	367	84	rj	rj	PROPN
fnp-6316	367	85	,	,	PUNCT
fnp-6316	367	86	onar	onar	PROPN
fnp-6316	367	87	-	-	PUNCT
fnp-6316	367	88	thomas	thomas	PROPN
fnp-6316	367	89	a	a	PRON
fnp-6316	367	90	,	,	PUNCT
fnp-6316	367	91	gajjar	gajjar	NOUN
fnp-6316	367	92	a	a	PRON
fnp-6316	367	93	,	,	PUNCT
fnp-6316	367	94	robinson	robinson	PROPN
fnp-6316	367	95	gw	gw	PROPN
fnp-6316	367	96	,	,	PUNCT
fnp-6316	367	97	northcott	northcott	PROPN
fnp-6316	367	98	pa	pa	PROPN
fnp-6316	367	99	.	.	PROPN
fnp-6316	367	100	serial	serial	ADJ
fnp-6316	367	101	assessment	assessment	NOUN
fnp-6316	367	102	of	of	ADP
fnp-6316	367	103	measurable	measurable	ADJ
fnp-6316	367	104	residual	residual	ADJ
fnp-6316	367	105	disease	disease	NOUN
fnp-6316	367	106	in	in	ADP
fnp-6316	367	107	medulloblastoma	medulloblastoma	ADJ
fnp-6316	367	108	liquid	liquid	ADJ
fnp-6316	367	109	biopsies	biopsy	NOUN
fnp-6316	367	110	.	.	PUNCT
fnp-6316	368	1	cancer	cancer	NOUN
fnp-6316	368	2	cell	cell	NOUN
fnp-6316	368	3	.	.	PUNCT
fnp-6316	369	1	2021	2021	NUM
fnp-6316	369	2	nov	nov	NOUN
fnp-6316	369	3	8;39(11):15191530.e4	8;39(11):15191530.e4	NUM
fnp-6316	369	4	.	.	PUNCT
fnp-6316	370	1	https://doi.org/10.1016/j.ccell.2021.09.012	https://doi.org/10.1016/j.ccell.2021.09.012	PROPN
fnp-6316	370	2	https://doi.org/10.17879/freeneuropathology-2025https://doi.org/10.1038/nature26000	https://doi.org/10.17879/freeneuropathology-2025https://doi.org/10.1038/nature26000	PROPN
fnp-6316	370	3	https://doi.org/10.1038/s41586-024-07751-z	https://doi.org/10.1038/s41586-024-07751-z	NOUN
fnp-6316	370	4	https://doi.org/10.3174/ajnr.a7004	https://doi.org/10.3174/ajnr.a7004	VERB
fnp-6316	370	5	https://doi.org/10.1093/neuonc/noaa247	https://doi.org/10.1093/neuonc/noaa247	X
fnp-6316	370	6	https://doi.org/10.1038/s41467-019-09853-z	https://doi.org/10.1038/s41467-019-09853-z	PROPN
fnp-6316	370	7	https://doi.org/10.1038/s41591-024-03152-x	https://doi.org/10.1038/s41591-024-03152-x	PROPN
fnp-6316	370	8	https://doi.org/10.1007/s00401-023-02677-8	https://doi.org/10.1007/s00401-023-02677-8	NUM
fnp-6316	370	9	https://doi.org/10.1007/s00701-023-05672-w	https://doi.org/10.1007/s00701-023-05672-w	PROPN
fnp-6316	370	10	https://doi.org/10.1093/neuonc/noac177	https://doi.org/10.1093/neuonc/noac177	NOUN
fnp-6316	370	11	https://doi.org/10.1093/neuonc/noad197	https://doi.org/10.1093/neuonc/noad197	NOUN
fnp-6316	370	12	https://doi.org/10.1186/s13073-025-01427-7	https://doi.org/10.1186/s13073-025-01427-7	VERB
fnp-6316	370	13	https://doi.org/10.1038/s41586-019-1024-7	https://doi.org/10.1038/s41586-019-1024-7	PROPN
fnp-6316	371	1	https://doi.org/10.1007/s10143-023-02169-z	https://doi.org/10.1007/s10143-023-02169-z	PROPN
fnp-6316	371	2	https://doi.org/10.1186/s40478-024-01846-4	https://doi.org/10.1186/s40478-024-01846-4	PUNCT
fnp-6316	372	1	https://doi.org/10.1038/nm.2072	https://doi.org/10.1038/nm.2072	NOUN
fnp-6316	372	2	https://doi.org/10.1038/s41598-024-76826-8	https://doi.org/10.1038/s41598-024-76826-8	PROPN
fnp-6316	372	3	https://doi.org/10.1016/j.cell.2023.11.032	https://doi.org/10.1016/j.cell.2023.11.032	NUM
fnp-6316	372	4	https://doi.org/10.1007/s10585-020-10055-x	https://doi.org/10.1007/s10585-020-10055-x	PROPN
fnp-6316	372	5	https://doi.org/10.1016/j.ccell.2021.09.012	https://doi.org/10.1016/j.ccell.2021.09.012	PROPN
fnp-6316	372	6	free	free	ADJ
fnp-6316	372	7	neuropathology	neuropathology	NOUN
fnp-6316	372	8	6:10	6:10	NUM
fnp-6316	372	9	(	(	PUNCT
fnp-6316	372	10	2025	2025	NUM
fnp-6316	372	11	)	)	PUNCT
fnp-6316	372	12	michel	michel	PROPN
fnp-6316	372	13	mittelbronn	mittelbronn	PROPN
fnp-6316	372	14	doi	doi	PROPN
fnp-6316	372	15	:	:	PUNCT
fnp-6316	372	16	https://doi.org/10.17879/freeneuropathology-2025-6316	https://doi.org/10.17879/freeneuropathology-2025-6316	NOUN
fnp-6316	372	17	page	page	NOUN
fnp-6316	372	18	19	19	NUM
fnp-6316	372	19	of	of	ADP
fnp-6316	372	20	19	19	NUM
fnp-6316	372	21	26	26	NUM
fnp-6316	372	22	.	.	PUNCT
fnp-6316	373	1	mallick	mallick	PROPN
fnp-6316	373	2	s	s	PROPN
fnp-6316	373	3	,	,	PUNCT
fnp-6316	373	4	benson	benson	PROPN
fnp-6316	373	5	r	r	PROPN
fnp-6316	373	6	,	,	PUNCT
fnp-6316	373	7	venkatesulu	venkatesulu	ADJ
fnp-6316	373	8	b	b	PROPN
fnp-6316	373	9	,	,	PUNCT
fnp-6316	373	10	melgandi	melgandi	VERB
fnp-6316	373	11	w	w	PROPN
fnp-6316	373	12	,	,	PUNCT
fnp-6316	373	13	rath	rath	PROPN
fnp-6316	373	14	gk	gk	PROPN
fnp-6316	373	15	.	.	PROPN
fnp-6316	374	1	systematic	systematic	PROPN
fnp-6316	374	2	review	review	NOUN
fnp-6316	374	3	and	and	CCONJ
fnp-6316	374	4	individual	individual	ADJ
fnp-6316	374	5	patient	patient	NOUN
fnp-6316	374	6	data	datum	NOUN
fnp-6316	374	7	analysis	analysis	NOUN
fnp-6316	374	8	of	of	ADP
fnp-6316	374	9	uncommon	uncommon	ADJ
fnp-6316	374	10	variants	variant	NOUN
fnp-6316	374	11	of	of	ADP
fnp-6316	374	12	glioblastoma	glioblastoma	NOUN
fnp-6316	374	13	:	:	PUNCT
fnp-6316	374	14	an	an	DET
fnp-6316	374	15	analysis	analysis	NOUN
fnp-6316	374	16	of	of	ADP
fnp-6316	374	17	196	196	NUM
fnp-6316	374	18	cases	case	NOUN
fnp-6316	374	19	.	.	PUNCT
fnp-6316	375	1	neurol	neurol	PROPN
fnp-6316	375	2	india	india	PROPN
fnp-6316	375	3	.	.	PUNCT
fnp-6316	376	1	2022	2022	NUM
fnp-6316	376	2	sep	sep	PROPN
fnp-6316	376	3	-	-	PUNCT
fnp-6316	376	4	oct;70(5):2086	oct;70(5):2086	NOUN
fnp-6316	376	5	-	-	PUNCT
fnp-6316	376	6	2092	2092	NUM
fnp-6316	376	7	.	.	PUNCT
fnp-6316	377	1	https://doi.org/10.4103/0028-3886.359222	https://doi.org/10.4103/0028-3886.359222	NOUN
fnp-6316	377	2	27	27	NUM
fnp-6316	377	3	.	.	PUNCT
fnp-6316	378	1	mathur	mathur	PROPN
fnp-6316	378	2	r	r	PROPN
fnp-6316	378	3	,	,	PUNCT
fnp-6316	378	4	wang	wang	PROPN
fnp-6316	378	5	q	q	PROPN
fnp-6316	378	6	,	,	PUNCT
fnp-6316	378	7	schupp	schupp	PROPN
fnp-6316	378	8	pg	pg	PROPN
fnp-6316	378	9	,	,	PUNCT
fnp-6316	378	10	nikolic	nikolic	PROPN
fnp-6316	378	11	a	a	NOUN
fnp-6316	378	12	,	,	PUNCT
fnp-6316	378	13	hilz	hilz	NOUN
fnp-6316	378	14	s	s	PROPN
fnp-6316	378	15	,	,	PUNCT
fnp-6316	378	16	hong	hong	PROPN
fnp-6316	378	17	c	c	NOUN
fnp-6316	378	18	,	,	PUNCT
fnp-6316	378	19	grishanina	grishanina	VERB
fnp-6316	378	20	nr	nr	PRON
fnp-6316	378	21	,	,	PUNCT
fnp-6316	378	22	kwok	kwok	PROPN
fnp-6316	378	23	d	d	PROPN
fnp-6316	378	24	,	,	PUNCT
fnp-6316	378	25	stevers	stever	NOUN
fnp-6316	378	26	no	no	INTJ
fnp-6316	378	27	,	,	PUNCT
fnp-6316	378	28	jin	jin	PROPN
fnp-6316	378	29	q	q	PROPN
fnp-6316	378	30	,	,	PUNCT
fnp-6316	378	31	youngblood	youngblood	PROPN
fnp-6316	378	32	mw	mw	PROPN
fnp-6316	378	33	,	,	PUNCT
fnp-6316	378	34	stasiak	stasiak	PROPN
fnp-6316	378	35	la	la	PROPN
fnp-6316	378	36	,	,	PUNCT
fnp-6316	378	37	hou	hou	PROPN
fnp-6316	378	38	y	y	PROPN
fnp-6316	378	39	,	,	PUNCT
fnp-6316	378	40	wang	wang	PROPN
fnp-6316	378	41	j	j	PROPN
fnp-6316	378	42	,	,	PUNCT
fnp-6316	378	43	yamaguchi	yamaguchi	PROPN
fnp-6316	378	44	tn	tn	PROPN
fnp-6316	378	45	,	,	PUNCT
fnp-6316	378	46	lafontaine	lafontaine	PROPN
fnp-6316	378	47	m	m	PROPN
fnp-6316	378	48	,	,	PUNCT
fnp-6316	378	49	shai	shai	PROPN
fnp-6316	378	50	a	a	PROPN
fnp-6316	378	51	,	,	PUNCT
fnp-6316	378	52	smirnov	smirnov	PROPN
fnp-6316	378	53	iv	iv	NUM
fnp-6316	378	54	,	,	PUNCT
fnp-6316	378	55	solomon	solomon	PROPN
fnp-6316	378	56	da	da	PROPN
fnp-6316	378	57	,	,	PUNCT
fnp-6316	378	58	chang	chang	PROPN
fnp-6316	378	59	sm	sm	PROPN
fnp-6316	378	60	,	,	PUNCT
fnp-6316	378	61	hervey	hervey	NOUN
fnp-6316	378	62	-	-	PUNCT
fnp-6316	378	63	jumper	jumper	NOUN
fnp-6316	378	64	sl	sl	NOUN
fnp-6316	378	65	,	,	PUNCT
fnp-6316	378	66	berger	berger	PROPN
fnp-6316	378	67	ms	ms	PROPN
fnp-6316	378	68	,	,	PUNCT
fnp-6316	378	69	lupo	lupo	PROPN
fnp-6316	378	70	jm	jm	PROPN
fnp-6316	378	71	,	,	PUNCT
fnp-6316	378	72	okada	okada	PROPN
fnp-6316	378	73	h	h	PROPN
fnp-6316	378	74	,	,	PUNCT
fnp-6316	378	75	phillips	phillips	PROPN
fnp-6316	378	76	jj	jj	PROPN
fnp-6316	378	77	,	,	PUNCT
fnp-6316	378	78	boutros	boutros	PROPN
fnp-6316	378	79	pc	pc	PROPN
fnp-6316	378	80	,	,	PUNCT
fnp-6316	378	81	gallo	gallo	PROPN
fnp-6316	378	82	m	m	PROPN
fnp-6316	378	83	,	,	PUNCT
fnp-6316	378	84	oldham	oldham	PROPN
fnp-6316	378	85	mc	mc	PROPN
fnp-6316	378	86	,	,	PUNCT
fnp-6316	378	87	yue	yue	PROPN
fnp-6316	378	88	f	f	PROPN
fnp-6316	378	89	,	,	PUNCT
fnp-6316	378	90	costello	costello	PROPN
fnp-6316	378	91	jf	jf	PROPN
fnp-6316	378	92	.	.	PROPN
fnp-6316	378	93	glioblastoma	glioblastoma	PROPN
fnp-6316	378	94	evolution	evolution	NOUN
fnp-6316	378	95	and	and	CCONJ
fnp-6316	378	96	heterogeneity	heterogeneity	NOUN
fnp-6316	378	97	from	from	ADP
fnp-6316	378	98	a	a	DET
fnp-6316	378	99	3d	3d	NUM
fnp-6316	378	100	whole	whole	ADJ
fnp-6316	378	101	-	-	PUNCT
fnp-6316	378	102	tumor	tumor	NOUN
fnp-6316	378	103	perspective	perspective	NOUN
fnp-6316	378	104	.	.	PUNCT
fnp-6316	379	1	cell	cell	NOUN
fnp-6316	379	2	.	.	PUNCT
fnp-6316	380	1	2024	2024	NUM
fnp-6316	380	2	jan	jan	NOUN
fnp-6316	380	3	18;187(2):446	18;187(2):446	NUM
fnp-6316	380	4	-	-	SYM
fnp-6316	380	5	463.e16	463.e16	NUM
fnp-6316	380	6	.	.	PUNCT
fnp-6316	381	1	https://doi.org/10.1016/j.cell.2023.12.013	https://doi.org/10.1016/j.cell.2023.12.013	PROPN
fnp-6316	381	2	28	28	NUM
fnp-6316	381	3	.	.	PUNCT
fnp-6316	382	1	mikkelsen	mikkelsen	PROPN
fnp-6316	382	2	ve	ve	PROPN
fnp-6316	382	3	,	,	PUNCT
fnp-6316	382	4	solheim	solheim	PROPN
fnp-6316	382	5	o	o	NOUN
fnp-6316	382	6	,	,	PUNCT
fnp-6316	382	7	salvesen	salvesen	PROPN
fnp-6316	382	8	ø	ø	PROPN
fnp-6316	382	9	,	,	PUNCT
fnp-6316	382	10	torp	torp	PROPN
fnp-6316	382	11	sh	sh	PROPN
fnp-6316	382	12	.	.	PUNCT
fnp-6316	383	1	the	the	DET
fnp-6316	383	2	histological	histological	ADJ
fnp-6316	383	3	representativeness	representativeness	NOUN
fnp-6316	383	4	of	of	ADP
fnp-6316	383	5	glioblastoma	glioblastoma	NOUN
fnp-6316	383	6	tissue	tissue	NOUN
fnp-6316	383	7	samples	sample	NOUN
fnp-6316	383	8	.	.	PUNCT
fnp-6316	384	1	acta	acta	PROPN
fnp-6316	384	2	neurochir	neurochir	PROPN
fnp-6316	384	3	(	(	PUNCT
fnp-6316	384	4	wien	wien	PROPN
fnp-6316	384	5	)	)	PUNCT
fnp-6316	384	6	.	.	PUNCT
fnp-6316	385	1	2021	2021	NUM
fnp-6316	385	2	jul;163(7):1911	jul;163(7):1911	PROPN
fnp-6316	385	3	-	-	PUNCT
fnp-6316	385	4	1920	1920	NUM
fnp-6316	385	5	.	.	PUNCT
fnp-6316	386	1	https://doi.org/10.1007/s00701-020-04608-y	https://doi.org/10.1007/s00701-020-04608-y	NOUN
fnp-6316	386	2	29	29	NUM
fnp-6316	386	3	.	.	PUNCT
fnp-6316	387	1	miller	miller	PROPN
fnp-6316	387	2	am	am	PROPN
fnp-6316	387	3	,	,	PUNCT
fnp-6316	387	4	shah	shah	PROPN
fnp-6316	387	5	rh	rh	PROPN
fnp-6316	387	6	,	,	PUNCT
fnp-6316	387	7	pentsova	pentsova	PROPN
fnp-6316	387	8	ei	ei	PROPN
fnp-6316	387	9	,	,	PUNCT
fnp-6316	387	10	pourmaleki	pourmaleki	PROPN
fnp-6316	387	11	m	m	PROPN
fnp-6316	387	12	,	,	PUNCT
fnp-6316	387	13	briggs	briggs	PROPN
fnp-6316	387	14	s	s	PROPN
fnp-6316	387	15	,	,	PUNCT
fnp-6316	387	16	distefano	distefano	PROPN
fnp-6316	387	17	n	n	CCONJ
fnp-6316	387	18	,	,	PUNCT
fnp-6316	387	19	zheng	zheng	PROPN
fnp-6316	387	20	y	y	PROPN
fnp-6316	387	21	,	,	PUNCT
fnp-6316	387	22	skakodub	skakodub	PROPN
fnp-6316	387	23	a	a	PROPN
fnp-6316	387	24	,	,	PUNCT
fnp-6316	387	25	mehta	mehta	PROPN
fnp-6316	387	26	sa	sa	PROPN
fnp-6316	387	27	,	,	PUNCT
fnp-6316	387	28	campos	campos	PROPN
fnp-6316	387	29	c	c	PROPN
fnp-6316	387	30	,	,	PUNCT
fnp-6316	387	31	hsieh	hsieh	PROPN
fnp-6316	387	32	wy	wy	PROPN
fnp-6316	387	33	,	,	PUNCT
fnp-6316	387	34	selcuklu	selcuklu	PROPN
fnp-6316	387	35	sd	sd	PROPN
fnp-6316	387	36	,	,	PUNCT
fnp-6316	387	37	ling	ling	PROPN
fnp-6316	387	38	l	l	PROPN
fnp-6316	387	39	,	,	PUNCT
fnp-6316	387	40	meng	meng	PROPN
fnp-6316	387	41	f	f	PROPN
fnp-6316	387	42	,	,	PUNCT
fnp-6316	387	43	jing	je	VERB
fnp-6316	387	44	x	x	SYM
fnp-6316	387	45	,	,	PUNCT
fnp-6316	387	46	samoila	samoila	NOUN
fnp-6316	387	47	a	a	NOUN
fnp-6316	387	48	,	,	PUNCT
fnp-6316	387	49	bale	bale	NOUN
fnp-6316	387	50	ta	ta	PROPN
fnp-6316	387	51	,	,	PUNCT
fnp-6316	387	52	tsui	tsui	PROPN
fnp-6316	387	53	dwy	dwy	NOUN
fnp-6316	387	54	,	,	PUNCT
fnp-6316	387	55	grommes	gromme	NOUN
fnp-6316	387	56	c	c	NOUN
fnp-6316	387	57	,	,	PUNCT
fnp-6316	387	58	viale	viale	NOUN
fnp-6316	387	59	a	a	DET
fnp-6316	387	60	,	,	PUNCT
fnp-6316	387	61	souweidane	souweidane	ADJ
fnp-6316	387	62	mm	mm	PROPN
fnp-6316	387	63	,	,	PUNCT
fnp-6316	387	64	tabar	tabar	PROPN
fnp-6316	387	65	v	v	PROPN
fnp-6316	387	66	,	,	PUNCT
fnp-6316	387	67	brennan	brennan	PROPN
fnp-6316	387	68	cw	cw	PROPN
fnp-6316	387	69	,	,	PUNCT
fnp-6316	387	70	reiner	reiner	NOUN
fnp-6316	387	71	as	as	ADP
fnp-6316	387	72	,	,	PUNCT
fnp-6316	387	73	rosenblum	rosenblum	PROPN
fnp-6316	387	74	m	m	PROPN
fnp-6316	387	75	,	,	PUNCT
fnp-6316	387	76	panageas	panageas	PROPN
fnp-6316	387	77	ks	ks	PROPN
fnp-6316	387	78	,	,	PUNCT
fnp-6316	387	79	deangelis	deangelis	PROPN
fnp-6316	387	80	lm	lm	PROPN
fnp-6316	387	81	,	,	PUNCT
fnp-6316	387	82	young	young	PROPN
fnp-6316	387	83	rj	rj	PROPN
fnp-6316	387	84	,	,	PUNCT
fnp-6316	387	85	berger	berger	PROPN
fnp-6316	387	86	mf	mf	PROPN
fnp-6316	387	87	,	,	PUNCT
fnp-6316	387	88	mellinghoff	mellinghoff	PROPN
fnp-6316	387	89	ik	ik	PROPN
fnp-6316	387	90	.	.	PUNCT
fnp-6316	387	91	tracking	track	VERB
fnp-6316	387	92	tumour	tumour	PRON
fnp-6316	387	93	evolution	evolution	NOUN
fnp-6316	387	94	in	in	ADP
fnp-6316	387	95	glioma	glioma	NOUN
fnp-6316	387	96	through	through	ADP
fnp-6316	387	97	liquid	liquid	ADJ
fnp-6316	387	98	biopsies	biopsy	NOUN
fnp-6316	387	99	of	of	ADP
fnp-6316	387	100	cerebrospinal	cerebrospinal	ADJ
fnp-6316	387	101	fluid	fluid	NOUN
fnp-6316	387	102	.	.	PUNCT
fnp-6316	388	1	nature	nature	NOUN
fnp-6316	388	2	.	.	PUNCT
fnp-6316	389	1	2019	2019	NUM
fnp-6316	389	2	jan;565(7741):654	jan;565(7741):654	ADV
fnp-6316	389	3	-	-	PUNCT
fnp-6316	389	4	658	658	NUM
fnp-6316	389	5	.	.	PUNCT
fnp-6316	390	1	https://doi.org/10.1038/s41586-019-0882-3	https://doi.org/10.1038/s41586-019-0882-3	NUM
fnp-6316	390	2	30	30	NUM
fnp-6316	390	3	.	.	PUNCT
fnp-6316	391	1	miller	miller	PROPN
fnp-6316	391	2	am	be	AUX
fnp-6316	391	3	,	,	PUNCT
fnp-6316	391	4	szalontay	szalontay	PROPN
fnp-6316	391	5	l	l	NOUN
fnp-6316	391	6	,	,	PUNCT
fnp-6316	391	7	bouvier	bouvier	PROPN
fnp-6316	391	8	n	n	CCONJ
fnp-6316	391	9	,	,	PUNCT
fnp-6316	391	10	hill	hill	PROPN
fnp-6316	391	11	k	k	PROPN
fnp-6316	391	12	,	,	PUNCT
fnp-6316	391	13	ahmad	ahmad	PROPN
fnp-6316	391	14	h	h	PROPN
fnp-6316	391	15	,	,	PUNCT
fnp-6316	391	16	rafailov	rafailov	PROPN
fnp-6316	391	17	j	j	PROPN
fnp-6316	391	18	,	,	PUNCT
fnp-6316	391	19	lee	lee	PROPN
fnp-6316	391	20	aj	aj	PROPN
fnp-6316	391	21	,	,	PUNCT
fnp-6316	391	22	rodriguez	rodriguez	PROPN
fnp-6316	391	23	-	-	PUNCT
fnp-6316	391	24	sanchez	sanchez	PROPN
fnp-6316	391	25	mi	mi	PROPN
fnp-6316	391	26	,	,	PUNCT
fnp-6316	391	27	yildirim	yildirim	PROPN
fnp-6316	391	28	o	o	PROPN
fnp-6316	391	29	,	,	PUNCT
fnp-6316	391	30	patel	patel	PROPN
fnp-6316	391	31	a	a	PRON
fnp-6316	391	32	,	,	PUNCT
fnp-6316	391	33	bale	bale	NOUN
fnp-6316	391	34	ta	ta	PROPN
fnp-6316	391	35	,	,	PUNCT
fnp-6316	391	36	benhamida	benhamida	PROPN
fnp-6316	391	37	jk	jk	PROPN
fnp-6316	391	38	,	,	PUNCT
fnp-6316	391	39	benayed	benaye	VERB
fnp-6316	391	40	r	r	NOUN
fnp-6316	391	41	,	,	PUNCT
fnp-6316	391	42	arcila	arcila	VERB
fnp-6316	391	43	me	i	PRON
fnp-6316	391	44	,	,	PUNCT
fnp-6316	391	45	donzelli	donzelli	PROPN
fnp-6316	391	46	m	m	PROPN
fnp-6316	391	47	,	,	PUNCT
fnp-6316	391	48	dunkel	dunkel	NOUN
fnp-6316	391	49	ij	ij	NOUN
fnp-6316	391	50	,	,	PUNCT
fnp-6316	391	51	gilheeney	gilheeney	PROPN
fnp-6316	391	52	sw	sw	PROPN
fnp-6316	391	53	,	,	PUNCT
fnp-6316	391	54	khakoo	khakoo	PROPN
fnp-6316	391	55	y	y	PROPN
fnp-6316	391	56	,	,	PUNCT
fnp-6316	391	57	kramer	kramer	PROPN
fnp-6316	391	58	k	k	PROPN
fnp-6316	391	59	,	,	PUNCT
fnp-6316	391	60	sait	sait	PROPN
fnp-6316	391	61	sf	sf	PROPN
fnp-6316	391	62	,	,	PUNCT
fnp-6316	391	63	greenfield	greenfield	NOUN
fnp-6316	391	64	jp	jp	NOUN
fnp-6316	391	65	,	,	PUNCT
fnp-6316	391	66	souweidane	souweidane	PROPN
fnp-6316	391	67	mm	mm	PROPN
fnp-6316	391	68	,	,	PUNCT
fnp-6316	391	69	haque	haque	PROPN
fnp-6316	391	70	s	s	PROPN
fnp-6316	391	71	,	,	PUNCT
fnp-6316	391	72	mauguen	mauguen	PROPN
fnp-6316	391	73	a	a	NOUN
fnp-6316	391	74	,	,	PUNCT
fnp-6316	391	75	berger	berger	PROPN
fnp-6316	391	76	mf	mf	PROPN
fnp-6316	391	77	,	,	PUNCT
fnp-6316	391	78	mellinghoff	mellinghoff	NOUN
fnp-6316	391	79	ik	ik	PROPN
fnp-6316	391	80	,	,	PUNCT
fnp-6316	391	81	karajannis	karajannis	PROPN
fnp-6316	391	82	ma	ma	PROPN
fnp-6316	391	83	.	.	PROPN
fnp-6316	392	1	next	next	ADJ
fnp-6316	392	2	-	-	PUNCT
fnp-6316	392	3	generation	generation	NOUN
fnp-6316	392	4	sequencing	sequencing	NOUN
fnp-6316	392	5	of	of	ADP
fnp-6316	392	6	cerebrospinal	cerebrospinal	ADJ
fnp-6316	392	7	fluid	fluid	NOUN
fnp-6316	392	8	for	for	ADP
fnp-6316	392	9	clinical	clinical	ADJ
fnp-6316	392	10	molecular	molecular	ADJ
fnp-6316	392	11	diagnostics	diagnostic	NOUN
fnp-6316	392	12	in	in	ADP
fnp-6316	392	13	pediatric	pediatric	ADJ
fnp-6316	392	14	,	,	PUNCT
fnp-6316	392	15	adolescent	adolescent	ADJ
fnp-6316	392	16	and	and	CCONJ
fnp-6316	392	17	young	young	ADJ
fnp-6316	392	18	adult	adult	NOUN
fnp-6316	392	19	brain	brain	NOUN
fnp-6316	392	20	tumor	tumor	NOUN
fnp-6316	392	21	patients	patient	NOUN
fnp-6316	392	22	.	.	PUNCT
fnp-6316	393	1	neuro	neuro	PROPN
fnp-6316	393	2	oncol	oncol	PROPN
fnp-6316	393	3	.	.	PUNCT
fnp-6316	394	1	2022	2022	NUM
fnp-6316	394	2	oct	oct	PROPN
fnp-6316	394	3	3;24(10):1763	3;24(10):1763	PROPN
fnp-6316	394	4	-	-	PROPN
fnp-6316	394	5	1772	1772	NUM
fnp-6316	394	6	.	.	PUNCT
fnp-6316	395	1	https://doi.org/10.1093/neuonc/noac035	https://doi.org/10.1093/neuonc/noac035	PROPN
fnp-6316	395	2	31	31	NUM
fnp-6316	395	3	.	.	PUNCT
fnp-6316	396	1	mittelbronn	mittelbronn	PROPN
fnp-6316	396	2	m.	m.	PROPN
fnp-6316	396	3	neurooncology	neurooncology	PROPN
fnp-6316	396	4	:	:	PUNCT
fnp-6316	396	5	2023	2023	NUM
fnp-6316	396	6	update	update	NOUN
fnp-6316	396	7	.	.	PUNCT
fnp-6316	397	1	free	free	ADJ
fnp-6316	397	2	neuropathol	neuropathol	NOUN
fnp-6316	397	3	.	.	PUNCT
fnp-6316	398	1	2023	2023	NUM
fnp-6316	398	2	mar	mar	PROPN
fnp-6316	398	3	20;4:4	20;4:4	NUM
fnp-6316	398	4	-	-	PUNCT
fnp-6316	398	5	4	4	NUM
fnp-6316	398	6	.	.	PUNCT
fnp-6316	399	1	https://doi.org/10.17879/freeneuropathology-2023-4692	https://doi.org/10.17879/freeneuropathology-2023-4692	PROPN
fnp-6316	399	2	.	.	PROPN
fnp-6316	399	3	32	32	NUM
fnp-6316	399	4	.	.	PUNCT
fnp-6316	400	1	mittelbronn	mittelbronn	PROPN
fnp-6316	400	2	m.	m.	PROPN
fnp-6316	400	3	neurooncology	neurooncology	PROPN
fnp-6316	400	4	:	:	PUNCT
fnp-6316	400	5	2024	2024	NUM
fnp-6316	400	6	update	update	NOUN
fnp-6316	400	7	.	.	PUNCT
fnp-6316	401	1	free	free	ADJ
fnp-6316	401	2	neuropathol	neuropathol	NOUN
fnp-6316	401	3	.	.	PUNCT
fnp-6316	402	1	2024	2024	NUM
fnp-6316	402	2	sep	sep	PROPN
fnp-6316	402	3	27;5:21	27;5:21	NUM
fnp-6316	402	4	.	.	PUNCT
fnp-6316	403	1	https://doi.org/10.17879/freeneuropathology-2024-5809	https://doi.org/10.17879/freeneuropathology-2024-5809	X
fnp-6316	403	2	.	.	PUNCT
fnp-6316	404	1	33	33	NUM
fnp-6316	404	2	.	.	PUNCT
fnp-6316	405	1	novis	novis	PROPN
fnp-6316	405	2	da	da	PROPN
fnp-6316	405	3	,	,	PUNCT
fnp-6316	405	4	zarbo	zarbo	PROPN
fnp-6316	405	5	rj	rj	PROPN
fnp-6316	405	6	.	.	PROPN
fnp-6316	405	7	interinstitutional	interinstitutional	ADJ
fnp-6316	405	8	comparison	comparison	NOUN
fnp-6316	405	9	of	of	ADP
fnp-6316	405	10	frozen	frozen	ADJ
fnp-6316	405	11	section	section	NOUN
fnp-6316	405	12	turnaround	turnaround	NOUN
fnp-6316	405	13	time	time	NOUN
fnp-6316	405	14	.	.	PUNCT
fnp-6316	406	1	a	a	DET
fnp-6316	406	2	college	college	NOUN
fnp-6316	406	3	of	of	ADP
fnp-6316	406	4	american	american	ADJ
fnp-6316	406	5	pathologists	pathologist	NOUN
fnp-6316	406	6	q	q	ADJ
fnp-6316	406	7	-	-	PUNCT
fnp-6316	406	8	probes	probe	NOUN
fnp-6316	406	9	study	study	NOUN
fnp-6316	406	10	of	of	ADP
fnp-6316	406	11	32868	32868	NUM
fnp-6316	406	12	frozen	frozen	ADJ
fnp-6316	406	13	sections	section	NOUN
fnp-6316	406	14	in	in	ADP
fnp-6316	406	15	700	700	NUM
fnp-6316	406	16	hospitals	hospital	NOUN
fnp-6316	406	17	.	.	PUNCT
fnp-6316	407	1	arch	arch	ADJ
fnp-6316	407	2	pathol	pathol	NOUN
fnp-6316	407	3	lab	lab	NOUN
fnp-6316	407	4	med	me	VERB
fnp-6316	407	5	.	.	PUNCT
fnp-6316	408	1	1997	1997	NUM
fnp-6316	408	2	jun;121(6):559	jun;121(6):559	NOUN
fnp-6316	408	3	-	-	PUNCT
fnp-6316	408	4	67	67	NUM
fnp-6316	408	5	.	.	PUNCT
fnp-6316	409	1	pmid	pmid	NOUN
fnp-6316	409	2	:	:	PUNCT
fnp-6316	409	3	9199619	9199619	NUM
fnp-6316	409	4	34	34	NUM
fnp-6316	409	5	.	.	PUNCT
fnp-6316	410	1	puchalski	puchalski	PROPN
fnp-6316	410	2	rb	rb	PROPN
fnp-6316	410	3	,	,	PUNCT
fnp-6316	410	4	shah	shah	NOUN
fnp-6316	410	5	n	n	CCONJ
fnp-6316	410	6	,	,	PUNCT
fnp-6316	410	7	miller	miller	PROPN
fnp-6316	410	8	j	j	PROPN
fnp-6316	410	9	,	,	PUNCT
fnp-6316	410	10	dalley	dalley	NOUN
fnp-6316	410	11	r	r	PROPN
fnp-6316	410	12	,	,	PUNCT
fnp-6316	410	13	nomura	nomura	PROPN
fnp-6316	410	14	sr	sr	PROPN
fnp-6316	410	15	,	,	PUNCT
fnp-6316	410	16	yoon	yoon	PROPN
fnp-6316	410	17	jg	jg	PROPN
fnp-6316	410	18	,	,	PUNCT
fnp-6316	410	19	smith	smith	PROPN
fnp-6316	410	20	ka	ka	PROPN
fnp-6316	410	21	,	,	PUNCT
fnp-6316	410	22	lankerovich	lankerovich	PROPN
fnp-6316	410	23	m	m	PROPN
fnp-6316	410	24	,	,	PUNCT
fnp-6316	410	25	bertagnolli	bertagnolli	PROPN
fnp-6316	410	26	d	d	PROPN
fnp-6316	410	27	,	,	PUNCT
fnp-6316	410	28	bickley	bickley	PROPN
fnp-6316	410	29	k	k	PROPN
fnp-6316	410	30	,	,	PUNCT
fnp-6316	410	31	boe	boe	PROPN
fnp-6316	410	32	af	af	PROPN
fnp-6316	410	33	,	,	PUNCT
fnp-6316	410	34	brouner	brouner	PROPN
fnp-6316	410	35	k	k	PROPN
fnp-6316	410	36	,	,	PUNCT
fnp-6316	410	37	butler	butler	PROPN
fnp-6316	410	38	s	s	PROPN
fnp-6316	410	39	,	,	PUNCT
fnp-6316	410	40	caldejon	caldejon	PROPN
fnp-6316	410	41	s	s	PROPN
fnp-6316	410	42	,	,	PUNCT
fnp-6316	410	43	chapin	chapin	PROPN
fnp-6316	410	44	m	m	PROPN
fnp-6316	410	45	,	,	PUNCT
fnp-6316	410	46	datta	datta	PROPN
fnp-6316	410	47	s	s	PROPN
fnp-6316	410	48	,	,	PUNCT
fnp-6316	410	49	dee	dee	PROPN
fnp-6316	410	50	n	n	X
fnp-6316	410	51	,	,	PUNCT
fnp-6316	410	52	desta	desta	PROPN
fnp-6316	410	53	t	t	PROPN
fnp-6316	410	54	,	,	PUNCT
fnp-6316	410	55	dolbeare	dolbeare	PROPN
fnp-6316	410	56	t	t	PROPN
fnp-6316	410	57	,	,	PUNCT
fnp-6316	410	58	dotson	dotson	PROPN
fnp-6316	410	59	n	n	CCONJ
fnp-6316	410	60	,	,	PUNCT
fnp-6316	410	61	ebbert	ebbert	VERB
fnp-6316	410	62	a	a	PRON
fnp-6316	410	63	,	,	PUNCT
fnp-6316	410	64	feng	feng	PROPN
fnp-6316	410	65	d	d	PROPN
fnp-6316	410	66	,	,	PUNCT
fnp-6316	410	67	feng	feng	PROPN
fnp-6316	410	68	x	x	PROPN
fnp-6316	410	69	,	,	PUNCT
fnp-6316	410	70	fisher	fisher	PROPN
fnp-6316	410	71	m	m	PROPN
fnp-6316	410	72	,	,	PUNCT
fnp-6316	410	73	gee	gee	INTJ
fnp-6316	410	74	g	g	NOUN
fnp-6316	410	75	,	,	PUNCT
fnp-6316	410	76	goldy	goldy	PROPN
fnp-6316	410	77	j	j	PROPN
fnp-6316	410	78	,	,	PUNCT
fnp-6316	410	79	gourley	gourley	PROPN
fnp-6316	410	80	l	l	PROPN
fnp-6316	410	81	,	,	PUNCT
fnp-6316	410	82	gregor	gregor	PROPN
fnp-6316	410	83	bw	bw	PROPN
fnp-6316	410	84	,	,	PUNCT
fnp-6316	410	85	gu	gu	NOUN
fnp-6316	410	86	g	g	PROPN
fnp-6316	410	87	,	,	PUNCT
fnp-6316	410	88	hejazinia	hejazinia	PROPN
fnp-6316	410	89	n	n	CCONJ
fnp-6316	410	90	,	,	PUNCT
fnp-6316	410	91	hohmann	hohmann	PROPN
fnp-6316	410	92	j	j	PROPN
fnp-6316	410	93	,	,	PUNCT
fnp-6316	410	94	hothi	hothi	PROPN
fnp-6316	410	95	p	p	X
fnp-6316	410	96	,	,	PUNCT
fnp-6316	410	97	howard	howard	PROPN
fnp-6316	410	98	r	r	PROPN
fnp-6316	410	99	,	,	PUNCT
fnp-6316	410	100	joines	joine	NOUN
fnp-6316	410	101	k	k	PROPN
fnp-6316	410	102	,	,	PUNCT
fnp-6316	410	103	kriedberg	kriedberg	PROPN
fnp-6316	410	104	a	a	PROPN
fnp-6316	410	105	,	,	PUNCT
fnp-6316	410	106	kuan	kuan	PROPN
fnp-6316	410	107	l	l	PROPN
fnp-6316	410	108	,	,	PUNCT
fnp-6316	410	109	lau	lau	PROPN
fnp-6316	410	110	c	c	PROPN
fnp-6316	410	111	,	,	PUNCT
fnp-6316	410	112	lee	lee	PROPN
fnp-6316	410	113	f	f	PROPN
fnp-6316	410	114	,	,	PUNCT
fnp-6316	410	115	lee	lee	PROPN
fnp-6316	410	116	h	h	PROPN
fnp-6316	410	117	,	,	PUNCT
fnp-6316	410	118	lemon	lemon	PROPN
fnp-6316	410	119	t	t	PROPN
fnp-6316	410	120	,	,	PUNCT
fnp-6316	410	121	long	long	ADJ
fnp-6316	410	122	f	f	PROPN
fnp-6316	410	123	,	,	PUNCT
fnp-6316	410	124	mastan	mastan	PROPN
fnp-6316	410	125	n	n	CCONJ
fnp-6316	410	126	,	,	PUNCT
fnp-6316	410	127	mott	mott	PROPN
fnp-6316	410	128	e	e	PROPN
fnp-6316	410	129	,	,	PUNCT
fnp-6316	410	130	murthy	murthy	PROPN
fnp-6316	410	131	c	c	PROPN
fnp-6316	410	132	,	,	PUNCT
fnp-6316	410	133	ngo	ngo	PROPN
fnp-6316	410	134	k	k	PROPN
fnp-6316	410	135	,	,	PUNCT
fnp-6316	410	136	olson	olson	NOUN
fnp-6316	410	137	e	e	PROPN
fnp-6316	410	138	,	,	PUNCT
fnp-6316	410	139	reding	rede	VERB
fnp-6316	410	140	m	m	PROPN
fnp-6316	410	141	,	,	PUNCT
fnp-6316	410	142	riley	riley	PROPN
fnp-6316	410	143	z	z	PROPN
fnp-6316	410	144	,	,	PUNCT
fnp-6316	410	145	rosen	rosen	PROPN
fnp-6316	410	146	d	d	PROPN
fnp-6316	410	147	,	,	PUNCT
fnp-6316	410	148	sandman	sandman	PROPN
fnp-6316	410	149	d	d	PROPN
fnp-6316	410	150	,	,	PUNCT
fnp-6316	410	151	shapovalova	shapovalova	PROPN
fnp-6316	410	152	n	n	CCONJ
fnp-6316	410	153	,	,	PUNCT
fnp-6316	410	154	slaughterbeck	slaughterbeck	PROPN
fnp-6316	410	155	cr	cr	PROPN
fnp-6316	410	156	,	,	PUNCT
fnp-6316	410	157	sodt	sodt	PROPN
fnp-6316	410	158	a	a	PROPN
fnp-6316	410	159	,	,	PUNCT
fnp-6316	410	160	stockdale	stockdale	PROPN
fnp-6316	410	161	g	g	PROPN
fnp-6316	410	162	,	,	PUNCT
fnp-6316	410	163	szafer	szafer	VERB
fnp-6316	410	164	a	a	PRON
fnp-6316	410	165	,	,	PUNCT
fnp-6316	410	166	wakeman	wakeman	PROPN
fnp-6316	410	167	w	w	PROPN
fnp-6316	410	168	,	,	PUNCT
fnp-6316	410	169	wohnoutka	wohnoutka	PROPN
fnp-6316	410	170	pe	pe	PROPN
fnp-6316	410	171	,	,	PUNCT
fnp-6316	410	172	white	white	PROPN
fnp-6316	410	173	sj	sj	PROPN
fnp-6316	410	174	,	,	PUNCT
fnp-6316	410	175	marsh	marsh	PROPN
fnp-6316	410	176	d	d	PROPN
fnp-6316	410	177	,	,	PUNCT
fnp-6316	410	178	rostomily	rostomily	PROPN
fnp-6316	410	179	rc	rc	PROPN
fnp-6316	410	180	,	,	PUNCT
fnp-6316	410	181	ng	ng	PROPN
fnp-6316	410	182	l	l	PROPN
fnp-6316	410	183	,	,	PUNCT
fnp-6316	410	184	dang	dang	PROPN
fnp-6316	410	185	c	c	PROPN
fnp-6316	410	186	,	,	PUNCT
fnp-6316	410	187	jones	jones	PROPN
fnp-6316	410	188	a	a	PROPN
fnp-6316	410	189	,	,	PUNCT
fnp-6316	410	190	keogh	keogh	PROPN
fnp-6316	410	191	b	b	PROPN
fnp-6316	410	192	,	,	PUNCT
fnp-6316	410	193	gittleman	gittleman	ADJ
fnp-6316	410	194	hr	hr	NOUN
fnp-6316	410	195	,	,	PUNCT
fnp-6316	410	196	barnholtz	barnholtz	NOUN
fnp-6316	410	197	-	-	PUNCT
fnp-6316	410	198	sloan	sloan	NOUN
fnp-6316	410	199	js	js	PROPN
fnp-6316	410	200	,	,	PUNCT
fnp-6316	410	201	cimino	cimino	PROPN
fnp-6316	410	202	pj	pj	PROPN
fnp-6316	410	203	,	,	PUNCT
fnp-6316	410	204	uppin	uppin	PROPN
fnp-6316	410	205	ms	ms	PROPN
fnp-6316	410	206	,	,	PUNCT
fnp-6316	410	207	keene	keene	PROPN
fnp-6316	410	208	cd	cd	PROPN
fnp-6316	410	209	,	,	PUNCT
fnp-6316	410	210	farrokhi	farrokhi	PROPN
fnp-6316	410	211	fr	fr	PROPN
fnp-6316	410	212	,	,	PUNCT
fnp-6316	410	213	lathia	lathia	PROPN
fnp-6316	410	214	jd	jd	PROPN
fnp-6316	410	215	,	,	PUNCT
fnp-6316	410	216	berens	beren	VERB
fnp-6316	410	217	me	i	PRON
fnp-6316	410	218	,	,	PUNCT
fnp-6316	410	219	iavarone	iavarone	NOUN
fnp-6316	410	220	a	a	NOUN
fnp-6316	410	221	,	,	PUNCT
fnp-6316	410	222	bernard	bernard	PROPN
fnp-6316	410	223	a	a	PRON
fnp-6316	410	224	,	,	PUNCT
fnp-6316	410	225	lein	lein	ADJ
fnp-6316	410	226	e	e	NOUN
fnp-6316	410	227	,	,	PUNCT
fnp-6316	410	228	phillips	phillips	PROPN
fnp-6316	410	229	jw	jw	PROPN
fnp-6316	410	230	,	,	PUNCT
fnp-6316	410	231	rostad	rostad	PROPN
fnp-6316	410	232	sw	sw	PROPN
fnp-6316	410	233	,	,	PUNCT
fnp-6316	410	234	cobbs	cobbs	PROPN
fnp-6316	410	235	c	c	PROPN
fnp-6316	410	236	,	,	PUNCT
fnp-6316	410	237	hawrylycz	hawrylycz	PROPN
fnp-6316	410	238	mj	mj	PROPN
fnp-6316	410	239	,	,	PUNCT
fnp-6316	410	240	foltz	foltz	PROPN
fnp-6316	410	241	gd	gd	PROPN
fnp-6316	410	242	.	.	PUNCT
fnp-6316	411	1	an	an	DET
fnp-6316	411	2	anatomic	anatomic	ADJ
fnp-6316	411	3	transcriptional	transcriptional	NOUN
fnp-6316	411	4	atlas	atlas	PROPN
fnp-6316	411	5	of	of	ADP
fnp-6316	411	6	human	human	ADJ
fnp-6316	411	7	glioblastoma	glioblastoma	NOUN
fnp-6316	411	8	.	.	PUNCT
fnp-6316	412	1	science	science	NOUN
fnp-6316	412	2	.	.	PUNCT
fnp-6316	413	1	2018	2018	NUM
fnp-6316	413	2	may	may	AUX
fnp-6316	413	3	11;360(6389):660	11;360(6389):660	NUM
fnp-6316	413	4	-	-	SYM
fnp-6316	413	5	663	663	NUM
fnp-6316	413	6	.	.	PUNCT
fnp-6316	414	1	https://doi.org/10.1126/science.aaf2666	https://doi.org/10.1126/science.aaf2666	ADJ
fnp-6316	414	2	35	35	NUM
fnp-6316	414	3	.	.	PUNCT
fnp-6316	415	1	ramsköld	ramsköld	NOUN
fnp-6316	415	2	d	d	PROPN
fnp-6316	415	3	,	,	PUNCT
fnp-6316	415	4	luo	luo	PROPN
fnp-6316	415	5	s	s	PROPN
fnp-6316	415	6	,	,	PUNCT
fnp-6316	415	7	wang	wang	PROPN
fnp-6316	415	8	yc	yc	PROPN
fnp-6316	415	9	,	,	PUNCT
fnp-6316	415	10	li	li	PROPN
fnp-6316	415	11	r	r	PROPN
fnp-6316	415	12	,	,	PUNCT
fnp-6316	415	13	deng	deng	PROPN
fnp-6316	415	14	q	q	X
fnp-6316	415	15	,	,	PUNCT
fnp-6316	415	16	faridani	faridani	ADJ
fnp-6316	415	17	or	or	CCONJ
fnp-6316	415	18	,	,	PUNCT
fnp-6316	415	19	daniels	daniels	PROPN
fnp-6316	415	20	ga	ga	PROPN
fnp-6316	415	21	,	,	PUNCT
fnp-6316	415	22	khrebtukova	khrebtukova	X
fnp-6316	416	1	i	i	PRON
fnp-6316	416	2	,	,	PUNCT
fnp-6316	416	3	loring	lore	VERB
fnp-6316	416	4	jf	jf	PROPN
fnp-6316	416	5	,	,	PUNCT
fnp-6316	416	6	laurent	laurent	PROPN
fnp-6316	416	7	lc	lc	PROPN
fnp-6316	416	8	,	,	PUNCT
fnp-6316	416	9	schroth	schroth	ADJ
fnp-6316	416	10	gp	gp	NOUN
fnp-6316	416	11	,	,	PUNCT
fnp-6316	416	12	sandberg	sandberg	PROPN
fnp-6316	416	13	r.	r.	PROPN
fnp-6316	416	14	full	full	ADJ
fnp-6316	416	15	-	-	PUNCT
fnp-6316	416	16	length	length	NOUN
fnp-6316	416	17	mrna	mrna	NOUN
fnp-6316	416	18	-	-	PUNCT
fnp-6316	416	19	seq	seq	NOUN
fnp-6316	416	20	from	from	ADP
fnp-6316	416	21	single	single	ADJ
fnp-6316	416	22	-	-	PUNCT
fnp-6316	416	23	cell	cell	NOUN
fnp-6316	416	24	levels	level	NOUN
fnp-6316	416	25	of	of	ADP
fnp-6316	416	26	rna	rna	PROPN
fnp-6316	416	27	and	and	CCONJ
fnp-6316	416	28	individual	individual	ADJ
fnp-6316	416	29	circulating	circulate	VERB
fnp-6316	416	30	tumor	tumor	NOUN
fnp-6316	416	31	cells	cell	NOUN
fnp-6316	416	32	.	.	PUNCT
fnp-6316	417	1	nat	nat	PROPN
fnp-6316	417	2	biotechnol	biotechnol	NOUN
fnp-6316	417	3	.	.	PUNCT
fnp-6316	418	1	2012	2012	NUM
fnp-6316	418	2	aug;30(8):777	aug;30(8):777	PROPN
fnp-6316	418	3	-	-	PUNCT
fnp-6316	418	4	82	82	PROPN
fnp-6316	418	5	.	.	PUNCT
fnp-6316	419	1	https://doi.org/10.1038/nbt.2282	https://doi.org/10.1038/nbt.2282	PROPN
fnp-6316	419	2	36	36	NUM
fnp-6316	419	3	.	.	PUNCT
fnp-6316	419	4	roesler	roesler	PROPN
fnp-6316	419	5	j	j	PROPN
fnp-6316	419	6	,	,	PUNCT
fnp-6316	419	7	spitzer	spitzer	PROPN
fnp-6316	419	8	d	d	PROPN
fnp-6316	419	9	,	,	PUNCT
fnp-6316	419	10	jia	jia	PROPN
fnp-6316	419	11	x	x	PROPN
fnp-6316	419	12	,	,	PUNCT
fnp-6316	419	13	aasen	aasen	PROPN
fnp-6316	419	14	sn	sn	PROPN
fnp-6316	419	15	,	,	PUNCT
fnp-6316	419	16	sommer	sommer	PROPN
fnp-6316	419	17	k	k	PROPN
fnp-6316	419	18	,	,	PUNCT
fnp-6316	419	19	roller	roller	NOUN
fnp-6316	419	20	b	b	PROPN
fnp-6316	419	21	,	,	PUNCT
fnp-6316	419	22	olshausen	olshausen	ADJ
fnp-6316	419	23	n	n	SYM
fnp-6316	419	24	,	,	PUNCT
fnp-6316	419	25	hebach	hebach	PROPN
fnp-6316	419	26	nr	nr	PROPN
fnp-6316	419	27	,	,	PUNCT
fnp-6316	419	28	albinger	albinger	NOUN
fnp-6316	419	29	n	n	PROPN
fnp-6316	419	30	,	,	PUNCT
fnp-6316	419	31	ullrich	ullrich	PROPN
fnp-6316	419	32	e	e	PROPN
fnp-6316	419	33	,	,	PUNCT
fnp-6316	419	34	zhu	zhu	PROPN
fnp-6316	419	35	l	l	NOUN
fnp-6316	419	36	,	,	PUNCT
fnp-6316	419	37	wang	wang	PROPN
fnp-6316	419	38	f	f	PROPN
fnp-6316	419	39	,	,	PUNCT
fnp-6316	419	40	macas	macas	PROPN
fnp-6316	419	41	j	j	PROPN
fnp-6316	419	42	,	,	PUNCT
fnp-6316	419	43	forster	forster	PROPN
fnp-6316	419	44	mt	mt	PROPN
fnp-6316	419	45	,	,	PUNCT
fnp-6316	419	46	steinbach	steinbach	PROPN
fnp-6316	419	47	jp	jp	PROPN
fnp-6316	419	48	,	,	PUNCT
fnp-6316	419	49	sevenich	sevenich	ADJ
fnp-6316	419	50	l	l	PROPN
fnp-6316	419	51	,	,	PUNCT
fnp-6316	419	52	devraj	devraj	PROPN
fnp-6316	419	53	k	k	PROPN
fnp-6316	419	54	,	,	PUNCT
fnp-6316	419	55	thorsen	thorsen	PROPN
fnp-6316	419	56	f	f	PROPN
fnp-6316	419	57	,	,	PUNCT
fnp-6316	419	58	karreman	karreman	PROPN
fnp-6316	419	59	ma	ma	PROPN
fnp-6316	419	60	,	,	PUNCT
fnp-6316	419	61	plate	plate	NOUN
fnp-6316	419	62	kh	kh	PROPN
fnp-6316	419	63	,	,	PUNCT
fnp-6316	419	64	reiss	reiss	PROPN
fnp-6316	419	65	y	y	PROPN
fnp-6316	419	66	,	,	PUNCT
fnp-6316	419	67	harter	harter	PROPN
fnp-6316	419	68	pn	pn	PROPN
fnp-6316	419	69	.	.	PROPN
fnp-6316	419	70	disturbance	disturbance	NOUN
fnp-6316	419	71	in	in	ADP
fnp-6316	419	72	cerebral	cerebral	ADJ
fnp-6316	419	73	blood	blood	NOUN
fnp-6316	419	74	microcirculation	microcirculation	NOUN
fnp-6316	419	75	and	and	CCONJ
fnp-6316	419	76	hypoxic	hypoxic	ADJ
fnp-6316	419	77	-	-	PUNCT
fnp-6316	419	78	ischemic	ischemic	ADJ
fnp-6316	419	79	microenvironment	microenvironment	NOUN
fnp-6316	419	80	are	be	AUX
fnp-6316	419	81	associated	associate	VERB
fnp-6316	419	82	with	with	ADP
fnp-6316	419	83	the	the	DET
fnp-6316	419	84	development	development	NOUN
fnp-6316	419	85	of	of	ADP
fnp-6316	419	86	brain	brain	NOUN
fnp-6316	419	87	metastasis	metastasis	NOUN
fnp-6316	419	88	.	.	PUNCT
fnp-6316	420	1	neuro	neuro	PROPN
fnp-6316	420	2	oncol	oncol	PROPN
fnp-6316	420	3	.	.	PUNCT
fnp-6316	421	1	2024	2024	NUM
fnp-6316	421	2	nov	nov	PROPN
fnp-6316	421	3	4;26(11):20842099	4;26(11):20842099	NUM
fnp-6316	421	4	.	.	PUNCT
fnp-6316	421	5	https://doi.org/10.1093/neuonc/noae094	https://doi.org/10.1093/neuonc/noae094	VERB
fnp-6316	421	6	37	37	NUM
fnp-6316	421	7	.	.	PUNCT
fnp-6316	421	8	smyth	smyth	PROPN
fnp-6316	421	9	lcd	lcd	PROPN
fnp-6316	421	10	,	,	PUNCT
fnp-6316	421	11	xu	xu	PROPN
fnp-6316	422	1	d	d	PROPN
fnp-6316	422	2	,	,	PUNCT
fnp-6316	422	3	okar	okar	PROPN
fnp-6316	422	4	sv	sv	PROPN
fnp-6316	422	5	,	,	PUNCT
fnp-6316	422	6	dykstra	dykstra	PROPN
fnp-6316	422	7	t	t	PROPN
fnp-6316	422	8	,	,	PUNCT
fnp-6316	422	9	rustenhoven	rustenhoven	PROPN
fnp-6316	422	10	j	j	PROPN
fnp-6316	422	11	,	,	PUNCT
fnp-6316	422	12	papadopoulos	papadopoulos	PROPN
fnp-6316	422	13	z	z	PROPN
fnp-6316	422	14	,	,	PUNCT
fnp-6316	422	15	bhasiin	bhasiin	VERB
fnp-6316	422	16	k	k	PROPN
fnp-6316	422	17	,	,	PUNCT
fnp-6316	422	18	kim	kim	PROPN
fnp-6316	422	19	mw	mw	PROPN
fnp-6316	422	20	,	,	PUNCT
fnp-6316	422	21	drieu	drieu	NOUN
fnp-6316	422	22	a	a	PRON
fnp-6316	422	23	,	,	PUNCT
fnp-6316	422	24	mamuladze	mamuladze	PROPN
fnp-6316	422	25	t	t	PROPN
fnp-6316	422	26	,	,	PUNCT
fnp-6316	422	27	blackburn	blackburn	PROPN
fnp-6316	422	28	s	s	PROPN
fnp-6316	422	29	,	,	PUNCT
fnp-6316	422	30	gu	gu	NOUN
fnp-6316	422	31	x	x	PROPN
fnp-6316	422	32	,	,	PUNCT
fnp-6316	422	33	gaitán	gaitán	PROPN
fnp-6316	422	34	mi	mi	PROPN
fnp-6316	422	35	,	,	PUNCT
fnp-6316	422	36	nair	nair	NOUN
fnp-6316	422	37	g	g	PROPN
fnp-6316	422	38	,	,	PUNCT
fnp-6316	422	39	storck	storck	VERB
fnp-6316	422	40	se	se	X
fnp-6316	422	41	,	,	PUNCT
fnp-6316	422	42	du	du	PROPN
fnp-6316	422	43	s	s	PROPN
fnp-6316	422	44	,	,	PUNCT
fnp-6316	422	45	white	white	PROPN
fnp-6316	422	46	ma	ma	PROPN
fnp-6316	422	47	,	,	PUNCT
fnp-6316	422	48	bayguinov	bayguinov	NOUN
fnp-6316	422	49	p	p	PRON
fnp-6316	422	50	,	,	PUNCT
fnp-6316	422	51	smirnov	smirnov	PROPN
fnp-6316	422	52	i	i	PROPN
fnp-6316	422	53	,	,	PUNCT
fnp-6316	422	54	dikranian	dikranian	PROPN
fnp-6316	422	55	k	k	PROPN
fnp-6316	422	56	,	,	PUNCT
fnp-6316	422	57	reich	reich	PROPN
fnp-6316	422	58	ds	ds	PROPN
fnp-6316	422	59	,	,	PUNCT
fnp-6316	422	60	kipnis	kipnis	NOUN
fnp-6316	422	61	j.	j.	PROPN
fnp-6316	422	62	identification	identification	NOUN
fnp-6316	422	63	of	of	ADP
fnp-6316	422	64	direct	direct	ADJ
fnp-6316	422	65	connections	connection	NOUN
fnp-6316	422	66	between	between	ADP
fnp-6316	422	67	the	the	DET
fnp-6316	422	68	dura	dura	NOUN
fnp-6316	422	69	and	and	CCONJ
fnp-6316	422	70	the	the	DET
fnp-6316	422	71	brain	brain	NOUN
fnp-6316	422	72	nature	nature	NOUN
fnp-6316	422	73	.	.	PUNCT
fnp-6316	423	1	2024	2024	NUM
fnp-6316	423	2	mar;627(8002):165	mar;627(8002):165	PROPN
fnp-6316	423	3	-	-	SYM
fnp-6316	423	4	173	173	NUM
fnp-6316	423	5	.	.	PUNCT
fnp-6316	424	1	https://doi.org/10.1038/s41586-023-06993-7	https://doi.org/10.1038/s41586-023-06993-7	PROPN
fnp-6316	424	2	38	38	NUM
fnp-6316	424	3	.	.	PUNCT
fnp-6316	425	1	stuckert	stuckert	PROPN
fnp-6316	425	2	a	a	PROPN
fnp-6316	425	3	,	,	PUNCT
fnp-6316	425	4	bertrand	bertrand	PROPN
fnp-6316	425	5	kc	kc	PROPN
fnp-6316	425	6	,	,	PUNCT
fnp-6316	425	7	wang	wang	PROPN
fnp-6316	425	8	p	p	PROPN
fnp-6316	425	9	,	,	PUNCT
fnp-6316	425	10	smith	smith	PROPN
fnp-6316	425	11	a	a	PROPN
fnp-6316	425	12	,	,	PUNCT
fnp-6316	425	13	mack	mack	PROPN
fnp-6316	425	14	sc	sc	PROPN
fnp-6316	425	15	.	.	PUNCT
fnp-6316	426	1	weighing	weigh	VERB
fnp-6316	426	2	ependymoma	ependymoma	NOUN
fnp-6316	426	3	as	as	ADP
fnp-6316	426	4	an	an	DET
fnp-6316	426	5	epigenetic	epigenetic	ADJ
fnp-6316	426	6	disease	disease	NOUN
fnp-6316	426	7	.	.	PUNCT
fnp-6316	427	1	j	j	PROPN
fnp-6316	427	2	neurooncol	neurooncol	PROPN
fnp-6316	427	3	.	.	PUNCT
fnp-6316	428	1	2020	2020	NUM
fnp-6316	428	2	oct	oct	NOUN
fnp-6316	428	3	;	;	PUNCT
fnp-6316	428	4	150(1	150(1	NUM
fnp-6316	428	5	):	):	PUNCT
fnp-6316	428	6	57	57	NUM
fnp-6316	428	7	-	-	SYM
fnp-6316	428	8	61	61	NUM
fnp-6316	428	9	.	.	PUNCT
fnp-6316	429	1	https://doi.org/10.1007/s11060-020-03562-0	https://doi.org/10.1007/s11060-020-03562-0	NUM
fnp-6316	429	2	39	39	NUM
fnp-6316	429	3	.	.	PUNCT
fnp-6316	429	4	tang	tang	PROPN
fnp-6316	430	1	f	f	X
fnp-6316	430	2	,	,	PUNCT
fnp-6316	430	3	barbacioru	barbacioru	NOUN
fnp-6316	430	4	c	c	PROPN
fnp-6316	430	5	,	,	PUNCT
fnp-6316	430	6	wang	wang	PROPN
fnp-6316	430	7	y	y	PROPN
fnp-6316	430	8	,	,	PUNCT
fnp-6316	430	9	nordman	nordman	NOUN
fnp-6316	430	10	e	e	PROPN
fnp-6316	430	11	,	,	PUNCT
fnp-6316	430	12	lee	lee	PROPN
fnp-6316	430	13	c	c	PROPN
fnp-6316	430	14	,	,	PUNCT
fnp-6316	430	15	xu	xu	PROPN
fnp-6316	430	16	n	n	CCONJ
fnp-6316	430	17	,	,	PUNCT
fnp-6316	430	18	wang	wang	PROPN
fnp-6316	430	19	x	x	PROPN
fnp-6316	430	20	,	,	PUNCT
fnp-6316	430	21	bodeau	bodeau	PROPN
fnp-6316	430	22	j	j	PROPN
fnp-6316	430	23	,	,	PUNCT
fnp-6316	430	24	tuch	tuch	PROPN
fnp-6316	430	25	bb	bb	PROPN
fnp-6316	430	26	,	,	PUNCT
fnp-6316	430	27	siddiqui	siddiqui	NOUN
fnp-6316	430	28	a	a	PROPN
fnp-6316	430	29	,	,	PUNCT
fnp-6316	430	30	lao	lao	PROPN
fnp-6316	430	31	k	k	PROPN
fnp-6316	430	32	,	,	PUNCT
fnp-6316	430	33	surani	surani	PROPN
fnp-6316	430	34	ma	ma	PROPN
fnp-6316	430	35	.	.	PROPN
fnp-6316	430	36	mrna	mrna	PROPN
fnp-6316	430	37	-	-	PUNCT
fnp-6316	430	38	seq	seq	NOUN
fnp-6316	430	39	wholetranscriptome	wholetranscriptome	NOUN
fnp-6316	430	40	analysis	analysis	NOUN
fnp-6316	430	41	of	of	ADP
fnp-6316	430	42	a	a	DET
fnp-6316	430	43	single	single	ADJ
fnp-6316	430	44	cell	cell	NOUN
fnp-6316	430	45	.	.	PUNCT
fnp-6316	431	1	nat	nat	NOUN
fnp-6316	431	2	methods	method	NOUN
fnp-6316	431	3	.	.	PUNCT
fnp-6316	432	1	2009	2009	NUM
fnp-6316	432	2	may;6(5):37782	may;6(5):37782	NOUN
fnp-6316	432	3	.	.	PUNCT
fnp-6316	433	1	https://doi.org/10.1038/nmeth.1315	https://doi.org/10.1038/nmeth.1315	ADJ
fnp-6316	433	2	40	40	NUM
fnp-6316	433	3	.	.	PUNCT
fnp-6316	434	1	venkataramani	venkataramani	PROPN
fnp-6316	434	2	v	v	PROPN
fnp-6316	434	3	,	,	PUNCT
fnp-6316	434	4	yang	yang	PROPN
fnp-6316	434	5	y	y	PROPN
fnp-6316	434	6	,	,	PUNCT
fnp-6316	434	7	ille	ille	PROPN
fnp-6316	434	8	s	s	PROPN
fnp-6316	434	9	,	,	PUNCT
fnp-6316	434	10	suchorska	suchorska	PROPN
fnp-6316	434	11	b	b	PROPN
fnp-6316	434	12	,	,	PUNCT
fnp-6316	434	13	loges	loges	PROPN
fnp-6316	434	14	s	s	PART
fnp-6316	434	15	,	,	PUNCT
fnp-6316	434	16	tost	tost	PROPN
fnp-6316	434	17	h	h	NOUN
fnp-6316	434	18	,	,	PUNCT
fnp-6316	434	19	sahm	sahm	PROPN
fnp-6316	434	20	f	f	PROPN
fnp-6316	434	21	,	,	PUNCT
fnp-6316	434	22	pfister	pfister	PROPN
fnp-6316	434	23	sm	sm	PROPN
fnp-6316	434	24	,	,	PUNCT
fnp-6316	434	25	trumpp	trumpp	PROPN
fnp-6316	434	26	a	a	PROPN
fnp-6316	434	27	,	,	PUNCT
fnp-6316	434	28	krieg	krieg	PROPN
fnp-6316	434	29	sm	sm	PROPN
fnp-6316	434	30	,	,	PUNCT
fnp-6316	434	31	kuner	kuner	PROPN
fnp-6316	434	32	t	t	PROPN
fnp-6316	434	33	,	,	PUNCT
fnp-6316	434	34	wick	wick	PROPN
fnp-6316	434	35	w	w	PROPN
fnp-6316	434	36	,	,	PUNCT
fnp-6316	434	37	winkler	winkler	PROPN
fnp-6316	434	38	f.	f.	PROPN
fnp-6316	434	39	cancer	cancer	PROPN
fnp-6316	434	40	neuroscience	neuroscience	NOUN
fnp-6316	434	41	of	of	ADP
fnp-6316	434	42	brain	brain	NOUN
fnp-6316	434	43	tumors	tumor	NOUN
fnp-6316	434	44	:	:	PUNCT
fnp-6316	434	45	from	from	ADP
fnp-6316	434	46	multicellular	multicellular	ADJ
fnp-6316	434	47	networks	network	NOUN
fnp-6316	434	48	to	to	ADP
fnp-6316	434	49	neuroscience	neuroscience	NOUN
fnp-6316	434	50	-	-	PUNCT
fnp-6316	434	51	instructed	instruct	VERB
fnp-6316	434	52	cancer	cancer	NOUN
fnp-6316	434	53	therapies	therapy	NOUN
fnp-6316	434	54	.	.	PUNCT
fnp-6316	435	1	cancer	cancer	NOUN
fnp-6316	435	2	discov	discov	NOUN
fnp-6316	435	3	.	.	PUNCT
fnp-6316	436	1	2025	2025	NUM
fnp-6316	436	2	jan	jan	PROPN
fnp-6316	436	3	13;15(1):39	13;15(1):39	PROPN
fnp-6316	436	4	-	-	SYM
fnp-6316	436	5	51	51	NUM
fnp-6316	436	6	.	.	PUNCT
fnp-6316	437	1	https://doi.org/10.1158/2159-8290.cd-24-0194	https://doi.org/10.1158/2159-8290.cd-24-0194	PROPN
fnp-6316	437	2	41	41	NUM
fnp-6316	437	3	.	.	PUNCT
fnp-6316	438	1	verhaak	verhaak	PROPN
fnp-6316	438	2	rg	rg	PROPN
fnp-6316	438	3	,	,	PUNCT
fnp-6316	438	4	hoadley	hoadley	PROPN
fnp-6316	438	5	ka	ka	PROPN
fnp-6316	438	6	,	,	PUNCT
fnp-6316	438	7	purdom	purdom	NOUN
fnp-6316	438	8	e	e	NOUN
fnp-6316	438	9	,	,	PUNCT
fnp-6316	438	10	wang	wang	PROPN
fnp-6316	438	11	v	v	PROPN
fnp-6316	438	12	,	,	PUNCT
fnp-6316	438	13	qi	qi	PROPN
fnp-6316	438	14	y	y	PROPN
fnp-6316	438	15	,	,	PUNCT
fnp-6316	438	16	wilkerson	wilkerson	PROPN
fnp-6316	438	17	md	md	PROPN
fnp-6316	438	18	,	,	PUNCT
fnp-6316	438	19	miller	miller	PROPN
fnp-6316	438	20	cr	cr	PROPN
fnp-6316	438	21	,	,	PUNCT
fnp-6316	438	22	ding	ding	NOUN
fnp-6316	438	23	l	l	PROPN
fnp-6316	438	24	,	,	PUNCT
fnp-6316	438	25	golub	golub	PROPN
fnp-6316	438	26	t	t	PROPN
fnp-6316	438	27	,	,	PUNCT
fnp-6316	438	28	mesirov	mesirov	PROPN
fnp-6316	438	29	jp	jp	PROPN
fnp-6316	438	30	,	,	PUNCT
fnp-6316	438	31	alexe	alexe	PROPN
fnp-6316	438	32	g	g	PROPN
fnp-6316	438	33	,	,	PUNCT
fnp-6316	438	34	lawrence	lawrence	PROPN
fnp-6316	438	35	m	m	PROPN
fnp-6316	438	36	,	,	PUNCT
fnp-6316	438	37	o'kelly	o'kelly	ADV
fnp-6316	438	38	m	m	PRON
fnp-6316	438	39	,	,	PUNCT
fnp-6316	438	40	tamayo	tamayo	PROPN
fnp-6316	438	41	p	p	PROPN
fnp-6316	438	42	,	,	PUNCT
fnp-6316	438	43	weir	weir	PROPN
fnp-6316	438	44	ba	ba	PROPN
fnp-6316	438	45	,	,	PUNCT
fnp-6316	438	46	gabriel	gabriel	PROPN
fnp-6316	438	47	s	s	PROPN
fnp-6316	438	48	,	,	PUNCT
fnp-6316	438	49	winckler	winckler	PROPN
fnp-6316	438	50	w	w	PROPN
fnp-6316	438	51	,	,	PUNCT
fnp-6316	438	52	gupta	gupta	PROPN
fnp-6316	438	53	s	s	PART
fnp-6316	438	54	,	,	PUNCT
fnp-6316	438	55	jakkula	jakkula	PROPN
fnp-6316	438	56	l	l	PROPN
fnp-6316	438	57	,	,	PUNCT
fnp-6316	438	58	feiler	feiler	PROPN
fnp-6316	438	59	hs	hs	PROPN
fnp-6316	438	60	,	,	PUNCT
fnp-6316	438	61	hodgson	hodgson	PROPN
fnp-6316	438	62	jg	jg	PROPN
fnp-6316	438	63	,	,	PUNCT
fnp-6316	438	64	james	james	PROPN
fnp-6316	438	65	cd	cd	PROPN
fnp-6316	438	66	,	,	PUNCT
fnp-6316	438	67	sarkaria	sarkaria	PROPN
fnp-6316	438	68	jn	jn	PROPN
fnp-6316	438	69	,	,	PUNCT
fnp-6316	438	70	brennan	brennan	PROPN
fnp-6316	438	71	c	c	PROPN
fnp-6316	438	72	,	,	PUNCT
fnp-6316	438	73	kahn	kahn	PROPN
fnp-6316	438	74	a	a	PROPN
fnp-6316	438	75	,	,	PUNCT
fnp-6316	438	76	spellman	spellman	PROPN
fnp-6316	438	77	pt	pt	PROPN
fnp-6316	438	78	,	,	PUNCT
fnp-6316	438	79	wilson	wilson	PROPN
fnp-6316	438	80	rk	rk	NOUN
fnp-6316	438	81	,	,	PUNCT
fnp-6316	438	82	speed	speed	NOUN
fnp-6316	438	83	tp	tp	NOUN
fnp-6316	438	84	,	,	PUNCT
fnp-6316	438	85	gray	gray	PROPN
fnp-6316	438	86	jw	jw	PROPN
fnp-6316	438	87	,	,	PUNCT
fnp-6316	438	88	meyerson	meyerson	PROPN
fnp-6316	438	89	m	m	PROPN
fnp-6316	438	90	,	,	PUNCT
fnp-6316	438	91	getz	getz	VERB
fnp-6316	438	92	g	g	NOUN
fnp-6316	438	93	,	,	PUNCT
fnp-6316	438	94	perou	perou	NOUN
fnp-6316	438	95	cm	cm	PROPN
fnp-6316	438	96	,	,	PUNCT
fnp-6316	438	97	hayes	hayes	PROPN
fnp-6316	438	98	dn	dn	PROPN
fnp-6316	438	99	;	;	PUNCT
fnp-6316	438	100	cancer	cancer	NOUN
fnp-6316	438	101	genome	genome	NOUN
fnp-6316	438	102	atlas	atlas	PROPN
fnp-6316	438	103	research	research	PROPN
fnp-6316	438	104	network	network	NOUN
fnp-6316	438	105	.	.	PUNCT
fnp-6316	439	1	integrated	integrate	VERB
fnp-6316	439	2	genomic	genomic	NOUN
fnp-6316	439	3	analysis	analysis	NOUN
fnp-6316	439	4	identifies	identify	VERB
fnp-6316	439	5	clinically	clinically	ADV
fnp-6316	439	6	relevant	relevant	ADJ
fnp-6316	439	7	subtypes	subtype	NOUN
fnp-6316	439	8	of	of	ADP
fnp-6316	439	9	glioblastoma	glioblastoma	NOUN
fnp-6316	439	10	characterized	characterize	VERB
fnp-6316	439	11	by	by	ADP
fnp-6316	439	12	abnormalities	abnormality	NOUN
fnp-6316	439	13	in	in	ADP
fnp-6316	439	14	pdgfra	pdgfra	NOUN
fnp-6316	439	15	,	,	PUNCT
fnp-6316	439	16	idh1	idh1	PROPN
fnp-6316	439	17	,	,	PUNCT
fnp-6316	439	18	egfr	egfr	NOUN
fnp-6316	439	19	,	,	PUNCT
fnp-6316	439	20	and	and	CCONJ
fnp-6316	439	21	nf1	nf1	NOUN
fnp-6316	439	22	.	.	PUNCT
fnp-6316	440	1	cancer	cancer	NOUN
fnp-6316	440	2	cell	cell	NOUN
fnp-6316	440	3	.	.	PUNCT
fnp-6316	441	1	2010	2010	NUM
fnp-6316	441	2	jan	jan	NOUN
fnp-6316	441	3	19;17(1):98	19;17(1):98	NUM
fnp-6316	441	4	-	-	SYM
fnp-6316	441	5	110	110	NUM
fnp-6316	441	6	.	.	PUNCT
fnp-6316	442	1	https://doi.org/10.1016/j.ccr.2009.12.020	https://doi.org/10.1016/j.ccr.2009.12.020	PROPN
fnp-6316	442	2	42	42	NUM
fnp-6316	442	3	.	.	PUNCT
fnp-6316	443	1	wagner	wagner	PROPN
fnp-6316	443	2	a	a	PROPN
fnp-6316	443	3	,	,	PUNCT
fnp-6316	443	4	brielmaier	brielmaier	PROPN
fnp-6316	443	5	mc	mc	PROPN
fnp-6316	443	6	,	,	PUNCT
fnp-6316	443	7	kampf	kampf	PROPN
fnp-6316	443	8	c	c	PROPN
fnp-6316	443	9	,	,	PUNCT
fnp-6316	443	10	baumgart	baumgart	PROPN
fnp-6316	443	11	l	l	PROPN
fnp-6316	443	12	,	,	PUNCT
fnp-6316	443	13	aftahy	aftahy	PROPN
fnp-6316	443	14	ak	ak	PROPN
fnp-6316	443	15	,	,	PUNCT
fnp-6316	443	16	meyer	meyer	PROPN
fnp-6316	443	17	hs	hs	PROPN
fnp-6316	443	18	,	,	PUNCT
fnp-6316	443	19	kehl	kehl	PROPN
fnp-6316	443	20	v	v	PROPN
fnp-6316	443	21	,	,	PUNCT
fnp-6316	443	22	höhne	höhne	PROPN
fnp-6316	443	23	j	j	PROPN
fnp-6316	443	24	,	,	PUNCT
fnp-6316	443	25	schebesch	schebesch	VERB
fnp-6316	443	26	km	km	PROPN
fnp-6316	443	27	,	,	PUNCT
fnp-6316	443	28	schmidt	schmidt	PROPN
fnp-6316	443	29	no	no	ADP
fnp-6316	443	30	,	,	PUNCT
fnp-6316	443	31	zoubaa	zoubaa	PROPN
fnp-6316	443	32	s	s	PROPN
fnp-6316	443	33	,	,	PUNCT
fnp-6316	443	34	riemenschneider	riemenschneider	PROPN
fnp-6316	443	35	mj	mj	PROPN
fnp-6316	443	36	,	,	PUNCT
fnp-6316	443	37	ratliff	ratliff	PROPN
fnp-6316	443	38	m	m	PROPN
fnp-6316	443	39	,	,	PUNCT
fnp-6316	443	40	enders	ender	NOUN
fnp-6316	443	41	f	f	PROPN
fnp-6316	443	42	,	,	PUNCT
fnp-6316	443	43	von	von	PROPN
fnp-6316	443	44	deimling	deimle	VERB
fnp-6316	443	45	a	a	PRON
fnp-6316	443	46	,	,	PUNCT
fnp-6316	443	47	liesche	liesche	NOUN
fnp-6316	443	48	-	-	PUNCT
fnp-6316	443	49	starnecker	starnecker	NOUN
fnp-6316	443	50	f	f	NOUN
fnp-6316	443	51	,	,	PUNCT
fnp-6316	443	52	delbridge	delbridge	VERB
fnp-6316	443	53	c	c	PROPN
fnp-6316	443	54	,	,	PUNCT
fnp-6316	443	55	schlegel	schlegel	PROPN
fnp-6316	443	56	j	j	PROPN
fnp-6316	443	57	,	,	PUNCT
fnp-6316	443	58	meyer	meyer	PROPN
fnp-6316	443	59	b	b	PROPN
fnp-6316	443	60	,	,	PUNCT
fnp-6316	443	61	gempt	gempt	PROPN
fnp-6316	443	62	j.	j.	PROPN
fnp-6316	443	63	fluorescein	fluorescein	PROPN
fnp-6316	443	64	-	-	PUNCT
fnp-6316	443	65	stained	stain	VERB
fnp-6316	443	66	confocal	confocal	ADJ
fnp-6316	443	67	laser	laser	NOUN
fnp-6316	443	68	endomicroscopy	endomicroscopy	VERB
fnp-6316	443	69	versus	versus	ADP
fnp-6316	443	70	conventional	conventional	ADJ
fnp-6316	443	71	frozen	frozen	ADJ
fnp-6316	443	72	section	section	NOUN
fnp-6316	443	73	for	for	ADP
fnp-6316	443	74	intraoperative	intraoperative	ADJ
fnp-6316	443	75	histopathological	histopathological	ADJ
fnp-6316	443	76	assessment	assessment	NOUN
fnp-6316	443	77	of	of	ADP
fnp-6316	443	78	intracranial	intracranial	ADJ
fnp-6316	443	79	tumors	tumor	NOUN
fnp-6316	443	80	.	.	PUNCT
fnp-6316	444	1	neuro	neuro	PROPN
fnp-6316	444	2	oncol	oncol	PROPN
fnp-6316	444	3	.	.	PUNCT
fnp-6316	445	1	2024	2024	NUM
fnp-6316	445	2	may	may	AUX
fnp-6316	445	3	3;26(5):922	3;26(5):922	NUM
fnp-6316	445	4	-	-	SYM
fnp-6316	445	5	932	932	NUM
fnp-6316	445	6	.	.	PUNCT
fnp-6316	446	1	https://doi.org/10.1093/neuonc/noae006	https://doi.org/10.1093/neuonc/noae006	NOUN
fnp-6316	447	1	43	43	NUM
fnp-6316	447	2	.	.	PUNCT
fnp-6316	448	1	world	world	PROPN
fnp-6316	448	2	health	health	PROPN
fnp-6316	448	3	organization	organization	PROPN
fnp-6316	448	4	classification	classification	NOUN
fnp-6316	448	5	of	of	ADP
fnp-6316	448	6	tumours	tumour	NOUN
fnp-6316	448	7	of	of	ADP
fnp-6316	448	8	the	the	DET
fnp-6316	448	9	central	central	ADJ
fnp-6316	448	10	nervous	nervous	ADJ
fnp-6316	448	11	system	system	NOUN
fnp-6316	448	12	.	.	PUNCT
fnp-6316	449	1	5th	5th	ADJ
fnp-6316	449	2	ed	ed	NOUN
fnp-6316	449	3	.	.	PUNCT
fnp-6316	450	1	lyon	lyon	PROPN
fnp-6316	450	2	:	:	PUNCT
fnp-6316	450	3	international	international	ADJ
fnp-6316	450	4	agency	agency	NOUN
fnp-6316	450	5	for	for	ADP
fnp-6316	450	6	research	research	NOUN
fnp-6316	450	7	on	on	ADP
fnp-6316	450	8	cancer	cancer	NOUN
fnp-6316	450	9	;	;	PUNCT
fnp-6316	450	10	2021	2021	NUM
fnp-6316	450	11	.	.	PUNCT
fnp-6316	451	1	https://doi.org/10.1093/neuonc/noab106	https://doi.org/10.1093/neuonc/noab106	PRON
fnp-6316	451	2	https://doi.org/10.17879/freeneuropathology-2025https://doi.org/10.4103/0028-3886.359222	https://doi.org/10.17879/freeneuropathology-2025https://doi.org/10.4103/0028-3886.359222	PROPN
fnp-6316	451	3	https://doi.org/10.1016/j.cell.2023.12.013	https://doi.org/10.1016/j.cell.2023.12.013	PROPN
fnp-6316	451	4	https://doi.org/10.1007/s00701-020-04608-y	https://doi.org/10.1007/s00701-020-04608-y	PROPN
fnp-6316	451	5	https://doi.org/10.1038/s41586-019-0882-3	https://doi.org/10.1038/s41586-019-0882-3	NUM
fnp-6316	451	6	https://doi.org/10.1093/neuonc/noac035	https://doi.org/10.1093/neuonc/noac035	PROPN
fnp-6316	451	7	https://doi.org/10.17879/freeneuropathology-2023-4692	https://doi.org/10.17879/freeneuropathology-2023-4692	PROPN
fnp-6316	451	8	https://doi.org/10.17879/freeneuropathology-2024-5809	https://doi.org/10.17879/freeneuropathology-2024-5809	PROPN
fnp-6316	451	9	https://pubmed.ncbi.nlm.nih.gov/9199619/	https://pubmed.ncbi.nlm.nih.gov/9199619/	PROPN
fnp-6316	451	10	https://doi.org/10.1126/science.aaf2666	https://doi.org/10.1126/science.aaf2666	VERB
fnp-6316	451	11	https://doi.org/10.1038/nbt.2282	https://doi.org/10.1038/nbt.2282	PROPN
fnp-6316	451	12	https://doi.org/10.1093/neuonc/noae094	https://doi.org/10.1093/neuonc/noae094	VERB
fnp-6316	451	13	https://doi.org/10.1038/s41586-023-06993-7	https://doi.org/10.1038/s41586-023-06993-7	NUM
fnp-6316	451	14	https://doi.org/10.1007/s11060-020-03562-0	https://doi.org/10.1007/s11060-020-03562-0	NUM
fnp-6316	451	15	https://doi.org/10.1038/nmeth.1315	https://doi.org/10.1038/nmeth.1315	ADV
fnp-6316	451	16	https://doi.org/10.1158/2159-8290.cd-24-0194	https://doi.org/10.1158/2159-8290.cd-24-0194	PROPN
fnp-6316	451	17	https://doi.org/10.1016/j.ccr.2009.12.020	https://doi.org/10.1016/j.ccr.2009.12.020	VERB
fnp-6316	451	18	https://doi.org/10.1093/neuonc/noae006	https://doi.org/10.1093/neuonc/noae006	NOUN
fnp-6316	451	19	https://doi.org/10.1093/neuonc/noab106	https://doi.org/10.1093/neuonc/noab106	NOUN
fnp-6316	451	20	review	review	VERB
fnp-6316	451	21	introduction	introduction	NOUN
fnp-6316	451	22	1	1	NUM
fnp-6316	451	23	.	.	PUNCT
fnp-6316	451	24	impact	impact	NOUN
fnp-6316	451	25	of	of	ADP
fnp-6316	451	26	disturbed	disturbed	ADJ
fnp-6316	451	27	cerebral	cerebral	ADJ
fnp-6316	451	28	microcirculation	microcirculation	NOUN
fnp-6316	451	29	and	and	CCONJ
fnp-6316	451	30	hypoxic	hypoxic	ADJ
fnp-6316	451	31	-	-	PUNCT
fnp-6316	451	32	ischemic	ischemic	ADJ
fnp-6316	451	33	microenvironment	microenvironment	NOUN
fnp-6316	451	34	on	on	ADP
fnp-6316	451	35	brain	brain	NOUN
fnp-6316	451	36	metastasis	metastasis	NOUN
fnp-6316	451	37	development	development	NOUN
fnp-6316	451	38	[	[	X
fnp-6316	451	39	roesler	roesler	NOUN
fnp-6316	451	40	et	et	PROPN
fnp-6316	451	41	al	al	PROPN
fnp-6316	451	42	.	.	PROPN
fnp-6316	451	43	,	,	PUNCT
fnp-6316	451	44	2024	2024	NUM
fnp-6316	451	45	]	]	PUNCT
fnp-6316	451	46	2	2	X
fnp-6316	451	47	.	.	X
fnp-6316	451	48	global	global	ADJ
fnp-6316	451	49	dna	dna	PROPN
fnp-6316	451	50	methylation	methylation	NOUN
fnp-6316	451	51	as	as	ADP
fnp-6316	451	52	independent	independent	ADJ
fnp-6316	451	53	diagnostic	diagnostic	ADJ
fnp-6316	451	54	marker	marker	NOUN
fnp-6316	451	55	in	in	ADP
fnp-6316	451	56	idh	idh	NOUN
fnp-6316	451	57	-	-	PUNCT
fnp-6316	451	58	wildtype	wildtype	NOUN
fnp-6316	451	59	glioblastoma	glioblastoma	NOUN
fnp-6316	452	1	[	[	X
fnp-6316	452	2	eckhardt	eckhardt	NOUN
fnp-6316	452	3	et	et	PROPN
fnp-6316	452	4	al	al	PROPN
fnp-6316	452	5	.	.	PROPN
fnp-6316	452	6	,	,	PUNCT
fnp-6316	452	7	2024	2024	NUM
fnp-6316	452	8	]	]	PUNCT
fnp-6316	452	9	3	3	X
fnp-6316	452	10	.	.	X
fnp-6316	452	11	change	change	NOUN
fnp-6316	452	12	in	in	ADP
fnp-6316	452	13	dna	dna	PROPN
fnp-6316	452	14	methylation	methylation	NOUN
fnp-6316	452	15	profile	profile	NOUN
fnp-6316	452	16	in	in	ADP
fnp-6316	452	17	recurrent	recurrent	ADJ
fnp-6316	452	18	glioblastoma	glioblastoma	NOUN
fnp-6316	452	19	[	[	X
fnp-6316	452	20	drexler	drexler	NOUN
fnp-6316	452	21	et	et	PROPN
fnp-6316	452	22	al	al	PROPN
fnp-6316	452	23	.	.	PROPN
fnp-6316	452	24	,	,	PUNCT
fnp-6316	452	25	2024	2024	NUM
fnp-6316	452	26	]	]	PUNCT
fnp-6316	452	27	4	4	X
fnp-6316	452	28	.	.	NOUN
fnp-6316	452	29	glioblastoma	glioblastoma	NOUN
fnp-6316	452	30	evolution	evolution	NOUN
fnp-6316	452	31	and	and	CCONJ
fnp-6316	452	32	heterogeneity	heterogeneity	NOUN
fnp-6316	452	33	from	from	ADP
fnp-6316	452	34	a	a	DET
fnp-6316	452	35	whole	whole	ADJ
fnp-6316	452	36	tumor	tumor	NOUN
fnp-6316	452	37	perspective	perspective	NOUN
fnp-6316	452	38	[	[	X
fnp-6316	452	39	mathur	mathur	PROPN
fnp-6316	452	40	et	et	PROPN
fnp-6316	452	41	al	al	PROPN
fnp-6316	452	42	.	.	PROPN
fnp-6316	452	43	,	,	PUNCT
fnp-6316	452	44	2024	2024	NUM
fnp-6316	452	45	]	]	PUNCT
fnp-6316	452	46	5	5	NUM
fnp-6316	452	47	.	.	PUNCT
fnp-6316	452	48	cranioencephalic	cranioencephalic	ADJ
fnp-6316	452	49	functional	functional	ADJ
fnp-6316	452	50	lymphoid	lymphoid	ADJ
fnp-6316	452	51	units	unit	NOUN
fnp-6316	452	52	in	in	ADP
fnp-6316	452	53	glioblastoma	glioblastoma	NOUN
fnp-6316	452	54	[	[	X
fnp-6316	452	55	dober	dober	NOUN
fnp-6316	452	56	-	-	PUNCT
fnp-6316	452	57	salske	salske	PROPN
fnp-6316	452	58	et	et	PROPN
fnp-6316	452	59	al	al	PROPN
fnp-6316	452	60	.	.	PROPN
fnp-6316	452	61	,	,	PUNCT
fnp-6316	452	62	2024	2024	NUM
fnp-6316	452	63	]	]	PUNCT
fnp-6316	452	64	7	7	X
fnp-6316	452	65	.	.	PUNCT
fnp-6316	452	66	confocal	confocal	ADJ
fnp-6316	452	67	laser	laser	NOUN
fnp-6316	452	68	microscopy	microscopy	NOUN
fnp-6316	452	69	for	for	ADP
fnp-6316	452	70	intraoperative	intraoperative	ADJ
fnp-6316	452	71	histopathological	histopathological	ADJ
fnp-6316	452	72	diagnostics	diagnostic	NOUN
fnp-6316	452	73	of	of	ADP
fnp-6316	452	74	intracranial	intracranial	ADJ
fnp-6316	452	75	tumors	tumor	NOUN
fnp-6316	453	1	[	[	X
fnp-6316	453	2	wagner	wagner	X
fnp-6316	453	3	et	et	PROPN
fnp-6316	453	4	al	al	PROPN
fnp-6316	453	5	.	.	PROPN
fnp-6316	453	6	,	,	PUNCT
fnp-6316	453	7	2024	2024	NUM
fnp-6316	453	8	]	]	PUNCT
fnp-6316	453	9	8	8	NUM
fnp-6316	453	10	.	.	PUNCT
fnp-6316	453	11	brain	brain	NOUN
fnp-6316	453	12	tumor	tumor	NOUN
fnp-6316	453	13	diagnostics	diagnostic	NOUN
fnp-6316	453	14	from	from	ADP
fnp-6316	453	15	cell	cell	NOUN
fnp-6316	453	16	-	-	PUNCT
fnp-6316	453	17	free	free	ADJ
fnp-6316	453	18	dna	dna	NOUN
fnp-6316	453	19	from	from	ADP
fnp-6316	453	20	cerebrospinal	cerebrospinal	ADJ
fnp-6316	453	21	fluid	fluid	NOUN
fnp-6316	453	22	[	[	X
fnp-6316	453	23	afflerbach	afflerbach	NOUN
fnp-6316	453	24	et	et	PROPN
fnp-6316	453	25	al	al	PROPN
fnp-6316	453	26	.	.	PROPN
fnp-6316	453	27	,	,	PUNCT
fnp-6316	453	28	2024	2024	NUM
fnp-6316	453	29	and	and	CCONJ
fnp-6316	453	30	hickman	hickman	PROPN
fnp-6316	453	31	et	et	PROPN
fnp-6316	453	32	al	al	PROPN
fnp-6316	453	33	.	.	PROPN
fnp-6316	453	34	,	,	PUNCT
fnp-6316	453	35	2024	2024	NUM
fnp-6316	453	36	]	]	PUNCT
fnp-6316	453	37	9	9	NUM
fnp-6316	453	38	.	.	NOUN
fnp-6316	453	39	time	time	NOUN
fnp-6316	453	40	-	-	PUNCT
fnp-6316	453	41	dependent	dependent	ADJ
fnp-6316	453	42	single	single	ADJ
fnp-6316	453	43	-	-	PUNCT
fnp-6316	453	44	cell	cell	NOUN
fnp-6316	453	45	phenotyping	phenotyping	NOUN
fnp-6316	453	46	of	of	ADP
fnp-6316	453	47	immune	immune	ADJ
fnp-6316	453	48	cells	cell	NOUN
fnp-6316	453	49	in	in	ADP
fnp-6316	453	50	glioblastoma	glioblastoma	NOUN
fnp-6316	454	1	[	[	X
fnp-6316	454	2	kirschenbaum	kirschenbaum	NOUN
fnp-6316	454	3	et	et	PROPN
fnp-6316	454	4	al	al	PROPN
fnp-6316	454	5	.	.	PROPN
fnp-6316	454	6	,	,	PUNCT
fnp-6316	454	7	2024	2024	NUM
fnp-6316	454	8	]	]	PUNCT
fnp-6316	454	9	10	10	NUM
fnp-6316	454	10	.	.	PUNCT
fnp-6316	455	1	histone	histone	NOUN
fnp-6316	455	2	serotonylation	serotonylation	PROPN
fnp-6316	455	3	regulates	regulate	VERB
fnp-6316	455	4	ependymoma	ependymoma	NOUN
fnp-6316	455	5	tumorigenesis	tumorigenesis	NOUN
fnp-6316	456	1	[	[	X
fnp-6316	456	2	chen	chen	PROPN
fnp-6316	456	3	et	et	PROPN
fnp-6316	456	4	al	al	PROPN
fnp-6316	456	5	.	.	PROPN
fnp-6316	456	6	,	,	PUNCT
fnp-6316	456	7	2024	2024	NUM
fnp-6316	456	8	]	]	PUNCT
fnp-6316	456	9	discussion	discussion	NOUN
fnp-6316	456	10	acknowledgements	acknowledgement	NOUN
fnp-6316	456	11	funding	fund	VERB
fnp-6316	456	12	statement	statement	NOUN
fnp-6316	456	13	conflict	conflict	NOUN
fnp-6316	456	14	of	of	ADP
fnp-6316	456	15	interest	interest	NOUN
fnp-6316	456	16	references	reference	NOUN