id	sid	tid	token	lemma	pos
fnp-8974	1	1	69th	69th	ADJ
fnp-8974	1	2	annual	annual	ADJ
fnp-8974	1	3	meeting	meeting	NOUN
fnp-8974	1	4	of	of	ADP
fnp-8974	1	5	the	the	DET
fnp-8974	1	6	german	german	ADJ
fnp-8974	1	7	society	society	NOUN
fnp-8974	1	8	of	of	ADP
fnp-8974	1	9	neuropathology	neuropathology	NOUN
fnp-8974	1	10	and	and	CCONJ
fnp-8974	1	11	neuroanatomy	neuroanatomy	NOUN
fnp-8974	1	12	(	(	PUNCT
fnp-8974	1	13	dgnn	dgnn	NOUN
fnp-8974	1	14	)	)	PUNCT
fnp-8974	1	15	meeting	meeting	NOUN
fnp-8974	1	16	abstracts	abstract	NOUN
fnp-8974	1	17	free	free	ADJ
fnp-8974	1	18	neuropathology	neuropathology	NOUN
fnp-8974	1	19	6:17	6:17	NUM
fnp-8974	1	20	(	(	PUNCT
fnp-8974	1	21	2025	2025	NUM
fnp-8974	1	22	)	)	PUNCT
fnp-8974	1	23	meeting	meeting	NOUN
fnp-8974	1	24	abstracts	abstract	VERB
fnp-8974	1	25	69th	69th	ADJ
fnp-8974	1	26	annual	annual	ADJ
fnp-8974	1	27	meeting	meeting	NOUN
fnp-8974	1	28	of	of	ADP
fnp-8974	1	29	the	the	DET
fnp-8974	1	30	german	german	ADJ
fnp-8974	1	31	society	society	NOUN
fnp-8974	1	32	of	of	ADP
fnp-8974	1	33	neuropathology	neuropathology	NOUN
fnp-8974	1	34	and	and	CCONJ
fnp-8974	1	35	neuroanatomy	neuroanatomy	NOUN
fnp-8974	1	36	(	(	PUNCT
fnp-8974	1	37	dgnn	dgnn	NOUN
fnp-8974	1	38	)	)	PUNCT
fnp-8974	1	39	meeting	meeting	NOUN
fnp-8974	1	40	abstracts	abstract	NOUN
fnp-8974	1	41	september	september	PROPN
fnp-8974	1	42	25–27	25–27	NUM
fnp-8974	1	43	,	,	PUNCT
fnp-8974	1	44	2025	2025	NUM
fnp-8974	1	45	,	,	PUNCT
fnp-8974	1	46	frankfurt	frankfurt	PROPN
fnp-8974	1	47	am	be	AUX
fnp-8974	1	48	main	main	ADJ
fnp-8974	1	49	,	,	PUNCT
fnp-8974	1	50	germany	germany	PROPN
fnp-8974	1	51	german	german	ADJ
fnp-8974	1	52	society	society	NOUN
fnp-8974	1	53	of	of	ADP
fnp-8974	1	54	neuropathology	neuropathology	NOUN
fnp-8974	1	55	and	and	CCONJ
fnp-8974	1	56	neuroanatomy	neuroanatomy	NOUN
fnp-8974	1	57	(	(	PUNCT
fnp-8974	1	58	dgnn	dgnn	NOUN
fnp-8974	1	59	)	)	PUNCT
fnp-8974	1	60	submitted	submit	VERB
fnp-8974	1	61	:	:	PUNCT
fnp-8974	1	62	15	15	NUM
fnp-8974	1	63	september	september	PROPN
fnp-8974	1	64	2025	2025	NUM
fnp-8974	1	65	accepted	accept	VERB
fnp-8974	1	66	:	:	PUNCT
fnp-8974	1	67	15	15	NUM
fnp-8974	1	68	september	september	PROPN
fnp-8974	1	69	2025	2025	NUM
fnp-8974	1	70	published	publish	VERB
fnp-8974	1	71	:	:	PUNCT
fnp-8974	2	1	18	18	NUM
fnp-8974	2	2	september	september	PROPN
fnp-8974	2	3	2025	2025	NUM
fnp-8974	2	4	https://doi.org/10.17879/freeneuropathology-2025-8974	https://doi.org/10.17879/freeneuropathology-2025-8974	NUM
fnp-8974	2	5	keywords	keyword	NOUN
fnp-8974	2	6	:	:	PUNCT
fnp-8974	2	7	german	german	ADJ
fnp-8974	2	8	society	society	NOUN
fnp-8974	2	9	of	of	ADP
fnp-8974	2	10	neuropathology	neuropathology	NOUN
fnp-8974	2	11	and	and	CCONJ
fnp-8974	2	12	neuroanatomy	neuroanatomy	NOUN
fnp-8974	2	13	,	,	PUNCT
fnp-8974	2	14	dgnn	dgnn	NOUN
fnp-8974	2	15	,	,	PUNCT
fnp-8974	2	16	meeting	meet	VERB
fnp-8974	2	17	abstracts	abstract	NOUN
fnp-8974	2	18	sehr	sehr	PROPN
fnp-8974	2	19	geehrte	geehrte	PROPN
fnp-8974	2	20	damen	damen	PROPN
fnp-8974	2	21	und	und	VERB
fnp-8974	2	22	herren	herren	PROPN
fnp-8974	2	23	,	,	PUNCT
fnp-8974	2	24	liebe	liebe	PROPN
fnp-8974	2	25	kolleginnen	kolleginnen	PROPN
fnp-8974	2	26	und	und	PROPN
fnp-8974	2	27	kollegen	kollegen	PROPN
fnp-8974	2	28	,	,	PUNCT
fnp-8974	2	29	i	i	PRON
fnp-8974	2	30	m	m	VERB
fnp-8974	2	31	namen	namen	PROPN
fnp-8974	2	32	der	der	PROPN
fnp-8974	2	33	deutschen	deutschen	PROPN
fnp-8974	2	34	gesellschaft	gesellschaft	PROPN
fnp-8974	2	35	für	für	PROPN
fnp-8974	2	36	neuropathologie	neuropathologie	X
fnp-8974	2	37	und	und	PROPN
fnp-8974	2	38	neuroanatomie	neuroanatomie	PROPN
fnp-8974	2	39	heiße	heiße	PROPN
fnp-8974	2	40	ich	ich	PROPN
fnp-8974	2	41	sie	sie	VERB
fnp-8974	2	42	herzlich	herzlich	PROPN
fnp-8974	2	43	willkommen	willkomman	NOUN
fnp-8974	2	44	zur	zur	NOUN
fnp-8974	2	45	69	69	NUM
fnp-8974	2	46	.	.	PUNCT
fnp-8974	3	1	jahrestagung	jahrestagung	PROPN
fnp-8974	3	2	unserer	unserer	PROPN
fnp-8974	3	3	fachgesellschaft	fachgesellschaft	PROPN
fnp-8974	3	4	,	,	PUNCT
fnp-8974	3	5	die	die	VERB
fnp-8974	3	6	in	in	ADP
fnp-8974	3	7	diesem	diesem	PROPN
fnp-8974	3	8	jahr	jahr	PROPN
fnp-8974	3	9	zudem	zudem	PROPN
fnp-8974	3	10	das	das	PROPN
fnp-8974	3	11	75	75	NUM
fnp-8974	3	12	-	-	PUNCT
fnp-8974	3	13	jährige	jährige	PROPN
fnp-8974	3	14	jubiläum	jubiläum	PROPN
fnp-8974	3	15	der	der	PROPN
fnp-8974	3	16	dgnn	dgnn	NOUN
fnp-8974	3	17	feiert	feiert	NOUN
fnp-8974	3	18	.	.	PUNCT
fnp-8974	4	1	dieses	diesis	NOUN
fnp-8974	4	2	besondere	besondere	VERB
fnp-8974	4	3	jubiläum	jubiläum	PROPN
fnp-8974	4	4	gibt	gibt	PROPN
fnp-8974	4	5	uns	un	NOUN
fnp-8974	4	6	anlass	anlass	PROPN
fnp-8974	4	7	,	,	PUNCT
fnp-8974	4	8	auf	auf	PROPN
fnp-8974	4	9	die	die	VERB
fnp-8974	4	10	wurzeln	wurzeln	PROPN
fnp-8974	4	11	und	und	NOUN
fnp-8974	4	12	die	die	PROPN
fnp-8974	4	13	beeindruckende	beeindruckende	PROPN
fnp-8974	4	14	entwicklung	entwicklung	PROPN
fnp-8974	4	15	unserer	unserer	PROPN
fnp-8974	4	16	fachgesellschaft	fachgesellschaft	PROPN
fnp-8974	4	17	zurückzublicken	zurückzublicken	VERB
fnp-8974	4	18	.	.	PUNCT
fnp-8974	5	1	die	die	VERB
fnp-8974	5	2	frankfurter	frankfurter	PROPN
fnp-8974	5	3	schule	schule	PROPN
fnp-8974	5	4	mit	mit	PROPN
fnp-8974	5	5	persönlichkeiten	persönlichkeiten	VERB
fnp-8974	5	6	wie	wie	PROPN
fnp-8974	5	7	carl	carl	PROPN
fnp-8974	5	8	weigert	weigert	PROPN
fnp-8974	5	9	und	und	PROPN
fnp-8974	5	10	ludwig	ludwig	PROPN
fnp-8974	5	11	edinger	edinger	PROPN
fnp-8974	5	12	legte	legte	PROPN
fnp-8974	5	13	wesentliche	wesentliche	PROPN
fnp-8974	5	14	grundlagen	grundlagen	PROPN
fnp-8974	5	15	für	für	PROPN
fnp-8974	5	16	die	die	VERB
fnp-8974	5	17	neurowissenschaften	neurowissenschaften	ADJ
fnp-8974	5	18	,	,	PUNCT
fnp-8974	5	19	deren	deren	PROPN
fnp-8974	5	20	bedeutung	bedeutung	PROPN
fnp-8974	5	21	bis	bis	PROPN
fnp-8974	5	22	heute	heute	PROPN
fnp-8974	5	23	kaum	kaum	PROPN
fnp-8974	5	24	zu	zu	PROPN
fnp-8974	5	25	überschätzen	überschätzen	NOUN
fnp-8974	5	26	ist	ist	NOUN
fnp-8974	5	27	.	.	PUNCT
fnp-8974	6	1	ein	ein	PROPN
fnp-8974	6	2	entscheidender	entscheidender	NOUN
fnp-8974	6	3	schritt	schritt	NOUN
fnp-8974	6	4	in	in	ADP
fnp-8974	6	5	der	der	ADJ
fnp-8974	6	6	geschichte	geschichte	NOUN
fnp-8974	6	7	unseres	unsere	NOUN
fnp-8974	6	8	faches	fache	NOUN
fnp-8974	6	9	war	war	NOUN
fnp-8974	6	10	der	der	NOUN
fnp-8974	6	11	zusammenschluss	zusammenschluss	PROPN
fnp-8974	6	12	der	der	PROPN
fnp-8974	6	13	neuropathologen	neuropathologen	PROPN
fnp-8974	6	14	in	in	ADP
fnp-8974	6	15	der	der	ADJ
fnp-8974	6	16	„	„	PUNCT
fnp-8974	6	17	arbeitsgemeinschaft	arbeitsgemeinschaft	NOUN
fnp-8974	6	18	morphologisch	morphologisch	PROPN
fnp-8974	6	19	arbeitender	arbeitender	PROPN
fnp-8974	6	20	neurologen	neurologen	PROPN
fnp-8974	6	21	und	und	PROPN
fnp-8974	6	22	psychiater	psychiater	ADJ
fnp-8974	6	23	“	"	PUNCT
fnp-8974	6	24	.	.	PUNCT
fnp-8974	7	1	unterstützt	unterstützt	ADJ
fnp-8974	7	2	durch	durch	NOUN
fnp-8974	7	3	den	den	PROPN
fnp-8974	7	4	pathologen	pathologen	NOUN
fnp-8974	7	5	prof	prof	NOUN
fnp-8974	7	6	.	.	PUNCT
fnp-8974	8	1	lauche	lauche	PROPN
fnp-8974	8	2	und	und	PROPN
fnp-8974	8	3	die	die	VERB
fnp-8974	8	4	frankfurter	frankfurter	PROPN
fnp-8974	8	5	edinger	edinger	NOUN
fnp-8974	8	6	-	-	PUNCT
fnp-8974	8	7	stiftung	stiftung	NOUN
fnp-8974	8	8	fanden	fanden	NOUN
fnp-8974	9	1	i	i	PROPN
fnp-8974	9	2	m	m	PROPN
fnp-8974	9	3	mai	mai	PROPN
fnp-8974	9	4	1950	1950	NUM
fnp-8974	9	5	vorgespräche	vorgespräche	PROPN
fnp-8974	9	6	statt	statt	PROPN
fnp-8974	9	7	,	,	PUNCT
fnp-8974	9	8	die	die	VERB
fnp-8974	9	9	schließlich	schließlich	PROPN
fnp-8974	9	10	am	be	AUX
fnp-8974	9	11	7	7	NUM
fnp-8974	9	12	.	.	PUNCT
fnp-8974	9	13	oktober	oktober	PROPN
fnp-8974	9	14	1950	1950	NUM
fnp-8974	9	15	zur	zur	NOUN
fnp-8974	9	16	gründungsversammlung	gründungsversammlung	NOUN
fnp-8974	9	17	der	der	NOUN
fnp-8974	9	18	„	„	PUNCT
fnp-8974	9	19	vereinigung	vereinigung	PROPN
fnp-8974	9	20	deutscher	deutscher	PROPN
fnp-8974	9	21	neuropathologen	neuropathologen	NOUN
fnp-8974	9	22	“	"	PUNCT
fnp-8974	9	23	führten	führten	NOUN
fnp-8974	9	24	.	.	PUNCT
fnp-8974	10	1	diese	diese	ADJ
fnp-8974	10	2	gründung	gründung	PROPN
fnp-8974	10	3	legte	legte	PROPN
fnp-8974	10	4	den	den	PROPN
fnp-8974	10	5	grundstein	grundstein	PROPN
fnp-8974	10	6	für	für	PROPN
fnp-8974	10	7	die	die	VERB
fnp-8974	10	8	heutige	heutige	PROPN
fnp-8974	10	9	dgnn	dgnn	NOUN
fnp-8974	10	10	,	,	PUNCT
fnp-8974	10	11	die	die	VERB
fnp-8974	10	12	seit	seit	PROPN
fnp-8974	10	13	75	75	NUM
fnp-8974	10	14	jahren	jahren	PROPN
fnp-8974	10	15	als	als	VERB
fnp-8974	10	16	wissenschaftliche	wissenschaftliche	PROPN
fnp-8974	10	17	plattform	plattform	PROPN
fnp-8974	10	18	für	für	PROPN
fnp-8974	10	19	austausch	austausch	PROPN
fnp-8974	10	20	und	und	VERB
fnp-8974	10	21	fortschritt	fortschritt	VERB
fnp-8974	10	22	i	i	PROPN
fnp-8974	10	23	m	m	PROPN
fnp-8974	10	24	bereich	bereich	PROPN
fnp-8974	10	25	der	der	NOUN
fnp-8974	10	26	neuropathologischen	neuropathologischen	ADV
fnp-8974	10	27	forschung	forschung	PROPN
fnp-8974	10	28	dient	dient	PROPN
fnp-8974	10	29	.	.	PUNCT
fnp-8974	11	1	besonders	besonder	NOUN
fnp-8974	11	2	hervorheben	hervorheben	PROPN
fnp-8974	11	3	möchte	möchte	PROPN
fnp-8974	11	4	ich	ich	PROPN
fnp-8974	11	5	den	den	PROPN
fnp-8974	11	6	hohen	hohen	X
fnp-8974	11	7	stellenwert	stellenwert	PROPN
fnp-8974	11	8	der	der	PROPN
fnp-8974	11	9	nachwuchsförderung	nachwuchsförderung	PROPN
fnp-8974	11	10	in	in	ADP
fnp-8974	11	11	unserer	unserer	PROPN
fnp-8974	11	12	gesellschaft	gesellschaft	PROPN
fnp-8974	11	13	.	.	PUNCT
fnp-8974	12	1	seit	seit	PROPN
fnp-8974	12	2	jeher	jeher	PROPN
fnp-8974	12	3	ist	ist	VERB
fnp-8974	12	4	es	es	ADP
fnp-8974	12	5	ein	ein	PROPN
fnp-8974	12	6	zentrales	zentrale	NOUN
fnp-8974	12	7	anliegen	anliegen	NOUN
fnp-8974	12	8	der	der	PROPN
fnp-8974	12	9	dgnn	dgnn	NOUN
fnp-8974	12	10	,	,	PUNCT
fnp-8974	12	11	junge	junge	PROPN
fnp-8974	12	12	wissenschaftlerinnen	wissenschaftlerinnen	PROPN
fnp-8974	12	13	und	und	VERB
fnp-8974	12	14	wissenschaftler	wissenschaftler	ADJ
fnp-8974	12	15	zu	zu	NOUN
fnp-8974	12	16	unterstützen	unterstützen	ADJ
fnp-8974	12	17	,	,	PUNCT
fnp-8974	12	18	zu	zu	NUM
fnp-8974	12	19	fördern	fördern	NOUN
fnp-8974	12	20	und	und	VERB
fnp-8974	12	21	ihnen	ihnen	PROPN
fnp-8974	12	22	eine	eine	PROPN
fnp-8974	12	23	plattform	plattform	PROPN
fnp-8974	12	24	für	für	PROPN
fnp-8974	12	25	ihre	ihre	PROPN
fnp-8974	12	26	wissenschaftliche	wissenschaftliche	PROPN
fnp-8974	12	27	entwicklung	entwicklung	PROPN
fnp-8974	12	28	zu	zu	PROPN
fnp-8974	12	29	bieten	bieten	PROPN
fnp-8974	12	30	.	.	PUNCT
fnp-8974	13	1	nur	nur	VERB
fnp-8974	13	2	durch	durch	NOUN
fnp-8974	13	3	die	die	NOUN
fnp-8974	13	4	gezielte	gezielte	PROPN
fnp-8974	13	5	förderung	förderung	PROPN
fnp-8974	13	6	des	des	PROPN
fnp-8974	13	7	wissenschaftlichen	wissenschaftlichen	ADV
fnp-8974	13	8	nachwuchses	nachwuchses	PROPN
fnp-8974	13	9	können	können	PROPN
fnp-8974	13	10	wir	wir	PROPN
fnp-8974	13	11	die	die	VERB
fnp-8974	13	12	zukunft	zukunft	PROPN
fnp-8974	13	13	unseres	unsere	NOUN
fnp-8974	13	14	fachgebiets	fachgebiet	VERB
fnp-8974	13	15	sichern	sichern	PROPN
fnp-8974	13	16	und	und	PROPN
fnp-8974	13	17	kontinuierlich	kontinuierlich	PROPN
fnp-8974	13	18	neue	neue	PROPN
fnp-8974	13	19	impulse	impulse	ADJ
fnp-8974	13	20	für	für	NOUN
fnp-8974	13	21	die	die	VERB
fnp-8974	13	22	neuropathologie	neuropathologie	X
fnp-8974	13	23	setzen	setzen	PROPN
fnp-8974	13	24	.	.	PUNCT
fnp-8974	14	1	der	der	PROPN
fnp-8974	14	2	kongress	kongress	PROPN
fnp-8974	14	3	2025	2025	NUM
fnp-8974	14	4	in	in	ADP
fnp-8974	14	5	frankfurt	frankfurt	PROPN
fnp-8974	14	6	am	be	AUX
fnp-8974	14	7	main	main	ADJ
fnp-8974	14	8	bietet	bietet	NOUN
fnp-8974	14	9	uns	un	NOUN
fnp-8974	14	10	erneut	erneut	NOUN
fnp-8974	14	11	die	die	VERB
fnp-8974	14	12	gelegenheit	gelegenheit	PROPN
fnp-8974	14	13	,	,	PUNCT
fnp-8974	14	14	in	in	ADP
fnp-8974	14	15	vorträgen	vorträgen	NOUN
fnp-8974	14	16	und	und	VERB
fnp-8974	14	17	diskussionen	diskussionen	PROPN
fnp-8974	14	18	die	die	NOUN
fnp-8974	14	19	neuesten	neuesten	VERB
fnp-8974	14	20	wissenschaftlichen	wissenschaftlichen	SCONJ
fnp-8974	14	21	erkenntnisse	erkenntnisse	PROPN
fnp-8974	14	22	zu	zu	PROPN
fnp-8974	14	23	erörtern	erörtern	PROPN
fnp-8974	14	24	sowie	sowie	PROPN
fnp-8974	14	25	den	den	PROPN
fnp-8974	14	26	kollegialen	kollegialen	PROPN
fnp-8974	14	27	austausch	austausch	PROPN
fnp-8974	14	28	zu	zu	PROPN
fnp-8974	14	29	pflegen	pflegen	PROPN
fnp-8974	14	30	.	.	PUNCT
fnp-8974	15	1	besonders	besonder	NOUN
fnp-8974	15	2	freue	freue	PROPN
fnp-8974	15	3	ich	ich	PROPN
fnp-8974	15	4	mich	mich	PROPN
fnp-8974	15	5	auf	auf	PROPN
fnp-8974	15	6	das	das	PROPN
fnp-8974	15	7	breite	breite	PROPN
fnp-8974	15	8	spektrum	spektrum	PROPN
fnp-8974	15	9	an	an	DET
fnp-8974	15	10	themen	themen	PROPN
fnp-8974	15	11	und	und	NOUN
fnp-8974	15	12	den	den	NOUN
fnp-8974	15	13	angeregten	angeregten	NOUN
fnp-8974	15	14	dialog	dialog	NOUN
fnp-8974	15	15	,	,	PUNCT
fnp-8974	15	16	der	der	ADJ
fnp-8974	15	17	unsere	unsere	NOUN
fnp-8974	15	18	fachgesellschaft	fachgesellschaft	NOUN
fnp-8974	15	19	lebendig	lebendig	NOUN
fnp-8974	15	20	hält	hält	NOUN
fnp-8974	15	21	.	.	PUNCT
fnp-8974	16	1	mein	mein	PROPN
fnp-8974	17	1	dank	dank	PROPN
fnp-8974	17	2	gilt	gilt	PROPN
fnp-8974	17	3	allen	allen	PROPN
fnp-8974	17	4	mitgliedern	mitgliedern	PROPN
fnp-8974	17	5	und	und	PROPN
fnp-8974	17	6	unterstützern	unterstützern	ADJ
fnp-8974	17	7	,	,	PUNCT
fnp-8974	17	8	die	die	VERB
fnp-8974	17	9	die	die	VERB
fnp-8974	17	10	dgnn	dgnn	PROPN
fnp-8974	17	11	mit	mit	PROPN
fnp-8974	17	12	ihrem	ihrem	PROPN
fnp-8974	17	13	engagement	engagement	NOUN
fnp-8974	17	14	und	und	NOUN
fnp-8974	17	15	ihrer	ihrer	PROPN
fnp-8974	17	16	leidenschaft	leidenschaft	PROPN
fnp-8974	17	17	prägen	prägen	PROPN
fnp-8974	17	18	und	und	NOUN
fnp-8974	17	19	voranbringen	voranbringen	NOUN
fnp-8974	17	20	.	.	PUNCT
fnp-8974	18	1	ich	ich	PROPN
fnp-8974	18	2	wünsche	wünsche	PROPN
fnp-8974	18	3	uns	uns	PROPN
fnp-8974	18	4	allen	allen	PROPN
fnp-8974	18	5	einen	einen	PROPN
fnp-8974	18	6	erfolgreichen	erfolgreichen	INTJ
fnp-8974	18	7	und	und	VERB
fnp-8974	18	8	inspirierenden	inspirierenden	PROPN
fnp-8974	18	9	kongress	kongress	PROPN
fnp-8974	18	10	sowie	sowie	PROPN
fnp-8974	18	11	ein	ein	PROPN
fnp-8974	18	12	bedeutungsvolles	bedeutungsvolle	VERB
fnp-8974	18	13	jubiläumsjahr	jubiläumsjahr	PROPN
fnp-8974	18	14	.	.	PUNCT
fnp-8974	19	1	mit	mit	VERB
fnp-8974	19	2	herzlichen	herzlichen	ADJ
fnp-8974	19	3	grüßen	grüßen	NOUN
fnp-8974	19	4	karl	karl	PROPN
fnp-8974	19	5	heinz	heinz	PROPN
fnp-8974	19	6	plate	plate	PROPN
fnp-8974	19	7	frankfurt	frankfurt	PROPN
fnp-8974	19	8	am	be	AUX
fnp-8974	19	9	main	main	ADJ
fnp-8974	19	10	,	,	PUNCT
fnp-8974	20	1	i	i	PRON
fnp-8974	20	2	m	m	VERB
fnp-8974	20	3	august	august	PROPN
fnp-8974	20	4	2025	2025	NUM
fnp-8974	20	5	contents	content	NOUN
fnp-8974	20	6	i.	i.	PROPN
fnp-8974	20	7	artificial	artificial	ADJ
fnp-8974	20	8	intelligence	intelligence	NOUN
fnp-8974	20	9	p01	p01	NOUN
fnp-8974	20	10	accurate	accurate	ADJ
fnp-8974	20	11	,	,	PUNCT
fnp-8974	20	12	inexpensive	inexpensive	ADJ
fnp-8974	20	13	&	&	CCONJ
fnp-8974	20	14	fast	fast	ADJ
fnp-8974	20	15	–	–	PUNCT
fnp-8974	20	16	computational	computational	ADJ
fnp-8974	20	17	pathology	pathology	NOUN
fnp-8974	20	18	for	for	ADP
fnp-8974	20	19	ependymoma	ependymoma	NOUN
fnp-8974	20	20	subtyping	subtype	VERB
fnp-8974	20	21	p02	p02	NUM
fnp-8974	20	22	three	three	NUM
fnp-8974	20	23	dimensional	dimensional	ADJ
fnp-8974	20	24	reconstruction	reconstruction	NOUN
fnp-8974	20	25	of	of	ADP
fnp-8974	20	26	neurons	neuron	NOUN
fnp-8974	20	27	and	and	CCONJ
fnp-8974	20	28	connectivity	connectivity	NOUN
fnp-8974	20	29	patterns	pattern	NOUN
fnp-8974	20	30	in	in	ADP
fnp-8974	20	31	the	the	DET
fnp-8974	20	32	human	human	ADJ
fnp-8974	20	33	spinal	spinal	PROPN
fnp-8974	20	34	cord	cord	PROPN
fnp-8974	20	35	ii	ii	PROPN
fnp-8974	20	36	.	.	PUNCT
fnp-8974	21	1	digital	digital	PROPN
fnp-8974	21	2	pathology	pathology	PROPN
fnp-8974	21	3	p03	p03	PROPN
fnp-8974	21	4	reliable	reliable	ADJ
fnp-8974	21	5	and	and	CCONJ
fnp-8974	21	6	instant	instant	ADJ
fnp-8974	21	7	slice	slice	NOUN
fnp-8974	21	8	-	-	PUNCT
fnp-8974	21	9	free	free	ADJ
fnp-8974	21	10	intraoperative	intraoperative	ADJ
fnp-8974	21	11	histology	histology	NOUN
fnp-8974	21	12	in	in	ADP
fnp-8974	21	13	neurooncology	neurooncology	NOUN
fnp-8974	21	14	:	:	PUNCT
fnp-8974	21	15	updated	update	VERB
fnp-8974	21	16	study	study	NOUN
fnp-8974	21	17	results	result	VERB
fnp-8974	21	18	with	with	ADP
fnp-8974	21	19	multiphoton	multiphoton	NOUN
fnp-8974	21	20	microscopy	microscopy	NOUN
fnp-8974	21	21	p04	p04	PROPN
fnp-8974	21	22	longitudinal	longitudinal	ADJ
fnp-8974	21	23	cell	cell	NOUN
fnp-8974	21	24	state	state	NOUN
fnp-8974	21	25	screening	screen	VERB
fnp-8974	21	26	through	through	ADP
fnp-8974	21	27	rapid	rapid	ADJ
fnp-8974	21	28	deconvolution	deconvolution	NOUN
fnp-8974	21	29	of	of	ADP
fnp-8974	21	30	intra	intra	ADJ
fnp-8974	21	31	-	-	ADJ
fnp-8974	21	32	tumor	tumor	ADJ
fnp-8974	21	33	heterogeneity	heterogeneity	NOUN
fnp-8974	21	34	in	in	ADP
fnp-8974	21	35	glioblastoma	glioblastoma	NOUN
fnp-8974	21	36	p05	p05	PROPN
fnp-8974	21	37	foundation	foundation	NOUN
fnp-8974	21	38	models	model	NOUN
fnp-8974	21	39	encode	encode	VERB
fnp-8974	21	40	technical	technical	ADJ
fnp-8974	21	41	biases	bias	NOUN
fnp-8974	21	42	:	:	PUNCT
fnp-8974	21	43	a	a	DET
fnp-8974	21	44	hidden	hidden	ADJ
fnp-8974	21	45	risk	risk	NOUN
fnp-8974	21	46	for	for	ADP
fnp-8974	21	47	multi	multi	ADJ
fnp-8974	21	48	-	-	ADJ
fnp-8974	21	49	institutional	institutional	ADJ
fnp-8974	21	50	histopathology	histopathology	NOUN
fnp-8974	21	51	ai	ai	PROPN
fnp-8974	21	52	iii	iii	PROPN
fnp-8974	21	53	.	.	PUNCT
fnp-8974	22	1	epilepsy	epilepsy	PROPN
fnp-8974	22	2	p06	p06	NOUN
fnp-8974	22	3	investigating	investigate	VERB
fnp-8974	22	4	neurological	neurological	ADJ
fnp-8974	22	5	deficits	deficit	NOUN
fnp-8974	22	6	in	in	ADP
fnp-8974	22	7	meis2	meis2	NOUN
fnp-8974	22	8	-	-	PUNCT
fnp-8974	22	9	related	relate	VERB
fnp-8974	22	10	syndrome	syndrome	NOUN
fnp-8974	22	11	using	use	VERB
fnp-8974	22	12	mescs	mesc	NOUN
fnp-8974	22	13	p07	p07	PROPN
fnp-8974	22	14	comparison	comparison	NOUN
fnp-8974	22	15	of	of	ADP
fnp-8974	22	16	neuroinflammatory	neuroinflammatory	ADJ
fnp-8974	22	17	cellular	cellular	ADJ
fnp-8974	22	18	composition	composition	NOUN
fnp-8974	22	19	of	of	ADP
fnp-8974	22	20	tumors	tumor	NOUN
fnp-8974	22	21	and	and	CCONJ
fnp-8974	22	22	peritumoral	peritumoral	ADJ
fnp-8974	22	23	tissue	tissue	NOUN
fnp-8974	22	24	in	in	ADP
fnp-8974	22	25	leat	leat	NOUN
fnp-8974	22	26	patients	patient	NOUN
fnp-8974	22	27	with	with	ADP
fnp-8974	22	28	and	and	CCONJ
fnp-8974	22	29	without	without	ADP
fnp-8974	22	30	post	post	ADJ
fnp-8974	22	31	-	-	ADJ
fnp-8974	22	32	surgical	surgical	ADJ
fnp-8974	22	33	persistence	persistence	NOUN
fnp-8974	22	34	of	of	ADP
fnp-8974	22	35	epilepsy	epilepsy	ADJ
fnp-8974	22	36	iv	iv	NUM
fnp-8974	22	37	.	.	PUNCT
fnp-8974	22	38	muscle	muscle	PROPN
fnp-8974	22	39	&	&	CCONJ
fnp-8974	22	40	nerve	nerve	PROPN
fnp-8974	22	41	p08	p08	NOUN
fnp-8974	22	42	diagnosis	diagnosis	NOUN
fnp-8974	22	43	of	of	ADP
fnp-8974	22	44	immune	immune	NOUN
fnp-8974	22	45	-	-	PUNCT
fnp-8974	22	46	mediated	mediate	VERB
fnp-8974	22	47	myopathies	myopathy	NOUN
fnp-8974	22	48	on	on	ADP
fnp-8974	22	49	formalin	formalin	NOUN
fnp-8974	22	50	-	-	PUNCT
fnp-8974	22	51	fixed	fix	VERB
fnp-8974	22	52	,	,	PUNCT
fnp-8974	22	53	paraffin	paraffin	NOUN
fnp-8974	22	54	-	-	PUNCT
fnp-8974	22	55	embedded	embed	VERB
fnp-8974	22	56	muscle	muscle	NOUN
fnp-8974	22	57	tissue	tissue	NOUN
fnp-8974	22	58	samples	sample	NOUN
fnp-8974	22	59	v.	v.	ADP
fnp-8974	22	60	neurodegeneration	neurodegeneration	NOUN
fnp-8974	22	61	p09	p09	NOUN
fnp-8974	22	62	the	the	DET
fnp-8974	22	63	interaction	interaction	NOUN
fnp-8974	22	64	between	between	ADP
fnp-8974	22	65	kallikrein-8	kallikrein-8	PROPN
fnp-8974	22	66	and	and	CCONJ
fnp-8974	22	67	its	its	PRON
fnp-8974	22	68	inhibitory	inhibitory	ADJ
fnp-8974	22	69	network	network	NOUN
fnp-8974	22	70	affects	affect	VERB
fnp-8974	22	71	alzheimer	alzheimer	PROPN
fnp-8974	22	72	’s	’s	PART
fnp-8974	22	73	disease	disease	NOUN
fnp-8974	22	74	p10	p10	NOUN
fnp-8974	22	75	associations	association	NOUN
fnp-8974	22	76	between	between	ADP
fnp-8974	22	77	age	age	NOUN
fnp-8974	22	78	,	,	PUNCT
fnp-8974	22	79	sex	sex	NOUN
fnp-8974	22	80	and	and	CCONJ
fnp-8974	22	81	apoe	apoe	ADJ
fnp-8974	22	82	with	with	ADP
fnp-8974	22	83	amyloid	amyloid	NOUN
fnp-8974	22	84	-	-	PUNCT
fnp-8974	22	85	beta	beta	NOUN
fnp-8974	22	86	,	,	PUNCT
fnp-8974	22	87	tau	tau	PROPN
fnp-8974	22	88	and	and	CCONJ
fnp-8974	22	89	α	α	X
fnp-8974	22	90	-	-	PUNCT
fnp-8974	22	91	synuclein	synuclein	NOUN
fnp-8974	22	92	loads	load	NOUN
fnp-8974	22	93	in	in	ADP
fnp-8974	22	94	alzheimer	alzheimer	PROPN
fnp-8974	22	95	’s	’s	PART
fnp-8974	22	96	disease	disease	NOUN
fnp-8974	22	97	p11	p11	NOUN
fnp-8974	22	98	white	white	ADJ
fnp-8974	22	99	matter	matter	VERB
fnp-8974	22	100	granular	granular	ADJ
fnp-8974	22	101	astrocytic	astrocytic	ADJ
fnp-8974	22	102	tau	tau	PROPN
fnp-8974	22	103	inclusions	inclusion	NOUN
fnp-8974	22	104	are	be	AUX
fnp-8974	22	105	a	a	DET
fnp-8974	22	106	highly	highly	ADV
fnp-8974	22	107	consistent	consistent	ADJ
fnp-8974	22	108	feature	feature	NOUN
fnp-8974	22	109	in	in	ADP
fnp-8974	22	110	multiple	multiple	ADJ
fnp-8974	22	111	system	system	NOUN
fnp-8974	22	112	atrophy	atrophy	NOUN
fnp-8974	22	113	p12	p12	NOUN
fnp-8974	22	114	impact	impact	NOUN
fnp-8974	22	115	of	of	ADP
fnp-8974	22	116	the	the	DET
fnp-8974	22	117	gut	gut	NOUN
fnp-8974	22	118	microbiome	microbiome	NOUN
fnp-8974	22	119	on	on	ADP
fnp-8974	22	120	microglia	microglia	ADJ
fnp-8974	22	121	and	and	CCONJ
fnp-8974	22	122	alzheimer	alzheimer	PROPN
fnp-8974	22	123	’s	’s	PART
fnp-8974	22	124	disease	disease	NOUN
fnp-8974	22	125	in	in	ADP
fnp-8974	22	126	different	different	ADJ
fnp-8974	22	127	mouse	mouse	NOUN
fnp-8974	22	128	models	model	NOUN
fnp-8974	22	129	p13	p13	VERB
fnp-8974	22	130	first	first	ADJ
fnp-8974	22	131	report	report	NOUN
fnp-8974	22	132	of	of	ADP
fnp-8974	22	133	clinico	clinico	NOUN
fnp-8974	22	134	-	-	PUNCT
fnp-8974	22	135	pathological	pathological	ADJ
fnp-8974	22	136	features	feature	NOUN
fnp-8974	22	137	associated	associate	VERB
fnp-8974	22	138	with	with	ADP
fnp-8974	22	139	tardbp	tardbp	NOUN
fnp-8974	22	140	p.m311v	p.m311v	PROPN
fnp-8974	22	141	mutation	mutation	NOUN
fnp-8974	22	142	vi	vi	PROPN
fnp-8974	22	143	.	.	PUNCT
fnp-8974	22	144	neuroinflammation	neuroinflammation	PROPN
fnp-8974	22	145	p14	p14	PROPN
fnp-8974	22	146	borna	borna	PROPN
fnp-8974	22	147	disease	disease	NOUN
fnp-8974	22	148	virus	virus	NOUN
fnp-8974	22	149	1	1	NUM
fnp-8974	22	150	infection	infection	NOUN
fnp-8974	22	151	in	in	ADP
fnp-8974	22	152	organotypic	organotypic	ADJ
fnp-8974	22	153	hippocampal	hippocampal	ADJ
fnp-8974	22	154	slide	slide	NOUN
fnp-8974	22	155	cultures	culture	NOUN
fnp-8974	22	156	from	from	ADP
fnp-8974	22	157	adult	adult	NOUN
fnp-8974	22	158	rats	rat	NOUN
fnp-8974	22	159	p15	p15	ADJ
fnp-8974	22	160	immune	immune	ADJ
fnp-8974	22	161	profile	profile	NOUN
fnp-8974	22	162	and	and	CCONJ
fnp-8974	22	163	clinical	clinical	ADJ
fnp-8974	22	164	characteristics	characteristic	NOUN
fnp-8974	22	165	of	of	ADP
fnp-8974	22	166	central	central	ADJ
fnp-8974	22	167	nervous	nervous	ADJ
fnp-8974	22	168	system	system	NOUN
fnp-8974	22	169	graft	graft	NOUN
fnp-8974	22	170	-	-	PUNCT
fnp-8974	22	171	versus	versus	ADP
fnp-8974	22	172	-	-	PUNCT
fnp-8974	22	173	host	host	NOUN
fnp-8974	22	174	-	-	PUNCT
fnp-8974	22	175	disease	disease	NOUN
fnp-8974	22	176	p16	p16	NOUN
fnp-8974	22	177	hpgv-1	hpgv-1	NUM
fnp-8974	22	178	is	be	AUX
fnp-8974	22	179	infecting	infect	VERB
fnp-8974	22	180	glial	glial	ADJ
fnp-8974	22	181	cells	cell	NOUN
fnp-8974	22	182	in	in	ADP
fnp-8974	22	183	immunosuppressed	immunosuppressed	ADJ
fnp-8974	22	184	patients	patient	NOUN
fnp-8974	22	185	p17	p17	VERB
fnp-8974	22	186	t	t	PROPN
fnp-8974	22	187	cell	cell	NOUN
fnp-8974	22	188	infiltration	infiltration	NOUN
fnp-8974	22	189	patterns	pattern	NOUN
fnp-8974	22	190	and	and	CCONJ
fnp-8974	22	191	clinical	clinical	ADJ
fnp-8974	22	192	correlates	correlate	NOUN
fnp-8974	22	193	in	in	ADP
fnp-8974	22	194	natalizumab	natalizumab	NOUN
fnp-8974	22	195	-	-	PUNCT
fnp-8974	22	196	related	relate	VERB
fnp-8974	22	197	pml	pml	NOUN
fnp-8974	22	198	lesions	lesion	NOUN
fnp-8974	22	199	p18	p18	ADJ
fnp-8974	22	200	multiplexed	multiplexed	ADJ
fnp-8974	22	201	viral	viral	ADJ
fnp-8974	22	202	detection	detection	NOUN
fnp-8974	22	203	in	in	ADP
fnp-8974	22	204	brain	brain	NOUN
fnp-8974	22	205	tissue	tissue	NOUN
fnp-8974	22	206	–	–	PUNCT
fnp-8974	22	207	methodological	methodological	ADJ
fnp-8974	22	208	challenges	challenge	NOUN
fnp-8974	22	209	and	and	CCONJ
fnp-8974	22	210	opportunities	opportunity	NOUN
fnp-8974	22	211	p19	p19	VERB
fnp-8974	22	212	neuropathological	neuropathological	ADJ
fnp-8974	22	213	characteristics	characteristic	NOUN
fnp-8974	22	214	of	of	ADP
fnp-8974	22	215	anti	anti	ADJ
fnp-8974	22	216	-	-	ADJ
fnp-8974	22	217	gaba	gaba	ADJ
fnp-8974	22	218	-	-	PUNCT
fnp-8974	22	219	b	b	NOUN
fnp-8974	22	220	-	-	PUNCT
fnp-8974	22	221	receptor	receptor	NOUN
fnp-8974	22	222	-	-	PUNCT
fnp-8974	22	223	encephalitis	encephalitis	NOUN
fnp-8974	22	224	p20	p20	NOUN
fnp-8974	22	225	impact	impact	NOUN
fnp-8974	22	226	of	of	ADP
fnp-8974	22	227	myelin	myelin	ADJ
fnp-8974	22	228	phagocytosis	phagocytosis	NOUN
fnp-8974	22	229	on	on	ADP
fnp-8974	22	230	human	human	ADJ
fnp-8974	22	231	blood	blood	NOUN
fnp-8974	22	232	-	-	PUNCT
fnp-8974	22	233	derived	derive	VERB
fnp-8974	22	234	macrophages	macrophage	NOUN
fnp-8974	22	235	and	and	CCONJ
fnp-8974	22	236	microglia	microglia	NOUN
fnp-8974	22	237	and	and	CCONJ
fnp-8974	22	238	its	its	PRON
fnp-8974	22	239	effect	effect	NOUN
fnp-8974	22	240	on	on	ADP
fnp-8974	22	241	human	human	ADJ
fnp-8974	22	242	oligodendrocytes	oligodendrocyte	NOUN
fnp-8974	22	243	p21	p21	NOUN
fnp-8974	22	244	remyelination	remyelination	NOUN
fnp-8974	22	245	in	in	ADP
fnp-8974	22	246	multiple	multiple	ADJ
fnp-8974	22	247	sclerosis	sclerosis	NOUN
fnp-8974	22	248	depends	depend	VERB
fnp-8974	22	249	on	on	ADP
fnp-8974	22	250	the	the	DET
fnp-8974	22	251	mechanism	mechanism	NOUN
fnp-8974	22	252	of	of	ADP
fnp-8974	22	253	lesion	lesion	NOUN
fnp-8974	22	254	development	development	NOUN
fnp-8974	22	255	p22	p22	NOUN
fnp-8974	22	256	il-12	il-12	ADP
fnp-8974	22	257	drives	drive	VERB
fnp-8974	22	258	neuroinflammation	neuroinflammation	NOUN
fnp-8974	22	259	-	-	PUNCT
fnp-8974	22	260	linked	link	VERB
fnp-8974	22	261	lipid	lipid	NOUN
fnp-8974	22	262	dysregulation	dysregulation	NOUN
fnp-8974	22	263	in	in	ADP
fnp-8974	22	264	a	a	DET
fnp-8974	22	265	mouse	mouse	NOUN
fnp-8974	22	266	model	model	NOUN
fnp-8974	22	267	of	of	ADP
fnp-8974	22	268	alzheimer	alzheimer	PROPN
fnp-8974	22	269	’s	’s	PART
fnp-8974	22	270	disease	disease	NOUN
fnp-8974	22	271	p23	p23	NOUN
fnp-8974	22	272	development	development	NOUN
fnp-8974	22	273	and	and	CCONJ
fnp-8974	22	274	validation	validation	NOUN
fnp-8974	22	275	of	of	ADP
fnp-8974	22	276	a	a	DET
fnp-8974	22	277	multiplex	multiplex	NOUN
fnp-8974	22	278	microarray	microarray	NOUN
fnp-8974	22	279	for	for	ADP
fnp-8974	22	280	pathogen	pathogen	NOUN
fnp-8974	22	281	detection	detection	NOUN
fnp-8974	22	282	in	in	ADP
fnp-8974	22	283	paraffin	paraffin	NOUN
fnp-8974	22	284	-	-	PUNCT
fnp-8974	22	285	embedded	embed	VERB
fnp-8974	22	286	cns	cns	NOUN
fnp-8974	22	287	tissue	tissue	NOUN
fnp-8974	22	288	vii	vii	PROPN
fnp-8974	22	289	.	.	PUNCT
fnp-8974	23	1	single	single	ADJ
fnp-8974	23	2	-	-	PUNCT
fnp-8974	23	3	cell	cell	NOUN
fnp-8974	23	4	technologies	technology	NOUN
fnp-8974	23	5	p24	p24	NOUN
fnp-8974	23	6	investigation	investigation	NOUN
fnp-8974	23	7	of	of	ADP
fnp-8974	23	8	intratumour	intratumour	NOUN
fnp-8974	23	9	heterogeneity	heterogeneity	NOUN
fnp-8974	23	10	in	in	ADP
fnp-8974	23	11	primary	primary	ADJ
fnp-8974	23	12	and	and	CCONJ
fnp-8974	23	13	recurrent	recurrent	ADJ
fnp-8974	23	14	glioblastoma	glioblastoma	NOUN
fnp-8974	23	15	via	via	ADP
fnp-8974	23	16	single	single	ADJ
fnp-8974	23	17	cell	cell	NOUN
fnp-8974	23	18	whole	whole	ADJ
fnp-8974	23	19	exome	exome	NOUN
fnp-8974	23	20	sequencing	sequence	VERB
fnp-8974	23	21	p25	p25	NOUN
fnp-8974	23	22	exploring	explore	VERB
fnp-8974	23	23	interand	interand	NOUN
fnp-8974	23	24	intratumoral	intratumoral	ADJ
fnp-8974	23	25	heterogeneity	heterogeneity	NOUN
fnp-8974	23	26	of	of	ADP
fnp-8974	23	27	choroid	choroid	NOUN
fnp-8974	23	28	plexus	plexus	NOUN
fnp-8974	23	29	tumors	tumor	NOUN
fnp-8974	23	30	on	on	ADP
fnp-8974	23	31	a	a	DET
fnp-8974	23	32	single	single	ADJ
fnp-8974	23	33	cell	cell	NOUN
fnp-8974	23	34	level	level	NOUN
fnp-8974	23	35	viii	viii	VERB
fnp-8974	23	36	.	.	PUNCT
fnp-8974	24	1	tumor	tumor	NOUN
fnp-8974	24	2	p26	p26	NOUN
fnp-8974	24	3	analysis	analysis	NOUN
fnp-8974	24	4	of	of	ADP
fnp-8974	24	5	histological	histological	ADJ
fnp-8974	24	6	,	,	PUNCT
fnp-8974	24	7	molecular	molecular	ADJ
fnp-8974	24	8	and	and	CCONJ
fnp-8974	24	9	preanalytic	preanalytic	ADJ
fnp-8974	24	10	features	feature	NOUN
fnp-8974	24	11	of	of	ADP
fnp-8974	24	12	unclassifiable	unclassifiable	ADJ
fnp-8974	24	13	cns	cns	NOUN
fnp-8974	24	14	specimens	specimen	NOUN
fnp-8974	24	15	:	:	PUNCT
fnp-8974	24	16	comparison	comparison	NOUN
fnp-8974	24	17	of	of	ADP
fnp-8974	24	18	the	the	DET
fnp-8974	24	19	heidelberg	heidelberg	PROPN
fnp-8974	24	20	v12.8e	v12.8e	PROPN
fnp-8974	24	21	,	,	PUNCT
fnp-8974	24	22	bethesda	bethesda	PROPN
fnp-8974	24	23	v3	v3	PROPN
fnp-8974	24	24	methylation	methylation	NOUN
fnp-8974	24	25	-	-	PUNCT
fnp-8974	24	26	based	base	VERB
fnp-8974	24	27	brain	brain	NOUN
fnp-8974	24	28	tumor	tumor	NOUN
fnp-8974	24	29	classifiers	classifier	NOUN
fnp-8974	24	30	and	and	CCONJ
fnp-8974	24	31	the	the	DET
fnp-8974	24	32	hetairos	hetairos	PROPN
fnp-8974	24	33	h&e	h&e	PROPN
fnp-8974	24	34	histology	histology	NOUN
fnp-8974	24	35	-	-	PUNCT
fnp-8974	24	36	based	base	VERB
fnp-8974	24	37	classifier	classifier	NOUN
fnp-8974	24	38	p27	p27	PROPN
fnp-8974	24	39	immunothrombosis	immunothrombosis	NOUN
fnp-8974	24	40	and	and	CCONJ
fnp-8974	24	41	endothelial	endothelial	ADJ
fnp-8974	24	42	priming	priming	NOUN
fnp-8974	24	43	in	in	ADP
fnp-8974	24	44	early	early	ADJ
fnp-8974	24	45	brain	brain	NOUN
fnp-8974	24	46	metastasis	metastasis	NOUN
fnp-8974	24	47	p28	p28	NOUN
fnp-8974	24	48	molecular	molecular	ADJ
fnp-8974	24	49	and	and	CCONJ
fnp-8974	24	50	histological	histological	ADJ
fnp-8974	24	51	analyses	analysis	NOUN
fnp-8974	24	52	of	of	ADP
fnp-8974	24	53	at	at	ADP
fnp-8974	24	54	/	/	SYM
fnp-8974	24	55	rt	rt	PROPN
fnp-8974	24	56	-	-	PUNCT
fnp-8974	24	57	tyr	tyr	PROPN
fnp-8974	24	58	suggest	suggest	VERB
fnp-8974	24	59	the	the	DET
fnp-8974	24	60	choroid	choroid	NOUN
fnp-8974	24	61	plexus	plexus	NOUN
fnp-8974	24	62	of	of	ADP
fnp-8974	24	63	the	the	DET
fnp-8974	24	64	fourth	fourth	ADJ
fnp-8974	24	65	ventricle	ventricle	NOUN
fnp-8974	24	66	as	as	ADP
fnp-8974	24	67	cellular	cellular	ADJ
fnp-8974	24	68	origin	origin	NOUN
fnp-8974	24	69	p29	p29	PROPN
fnp-8974	24	70	pediatric	pediatric	NOUN
fnp-8974	24	71	and	and	CCONJ
fnp-8974	24	72	aya	aya	PROPN
fnp-8974	24	73	meningiomas	meningiomas	PROPN
fnp-8974	24	74	exhibit	exhibit	VERB
fnp-8974	24	75	distinct	distinct	ADJ
fnp-8974	24	76	molecular	molecular	ADJ
fnp-8974	24	77	and	and	CCONJ
fnp-8974	24	78	clinical	clinical	ADJ
fnp-8974	24	79	features	feature	NOUN
fnp-8974	24	80	not	not	PART
fnp-8974	24	81	reflected	reflect	VERB
fnp-8974	24	82	in	in	ADP
fnp-8974	24	83	adult	adult	NOUN
fnp-8974	24	84	-	-	PUNCT
fnp-8974	24	85	based	base	VERB
fnp-8974	24	86	classification	classification	NOUN
fnp-8974	24	87	systems	system	NOUN
fnp-8974	24	88	p30	p30	NOUN
fnp-8974	24	89	case	case	NOUN
fnp-8974	24	90	of	of	ADP
fnp-8974	24	91	a	a	DET
fnp-8974	24	92	myxopapillary	myxopapillary	ADJ
fnp-8974	24	93	ependymoma	ependymoma	NOUN
fnp-8974	24	94	with	with	ADP
fnp-8974	24	95	multiple	multiple	ADJ
fnp-8974	24	96	relapses	relapse	NOUN
fnp-8974	24	97	and	and	CCONJ
fnp-8974	24	98	pulmonary	pulmonary	ADJ
fnp-8974	24	99	metastasis	metastasis	NOUN
fnp-8974	24	100	p31	p31	NOUN
fnp-8974	24	101	unravelling	unravel	VERB
fnp-8974	24	102	ependymoma	ependymoma	NOUN
fnp-8974	24	103	heterogeneity	heterogeneity	NOUN
fnp-8974	24	104	using	use	VERB
fnp-8974	24	105	integrated	integrated	ADJ
fnp-8974	24	106	proteomic	proteomic	NOUN
fnp-8974	24	107	analyses	analysis	NOUN
fnp-8974	24	108	p32	p32	ADJ
fnp-8974	24	109	identification	identification	NOUN
fnp-8974	24	110	of	of	ADP
fnp-8974	24	111	a	a	DET
fnp-8974	24	112	novel	novel	ADJ
fnp-8974	24	113	type	type	NOUN
fnp-8974	24	114	of	of	ADP
fnp-8974	24	115	pineal	pineal	ADJ
fnp-8974	24	116	region	region	NOUN
fnp-8974	24	117	tumors	tumor	NOUN
fnp-8974	24	118	with	with	ADP
fnp-8974	24	119	distinct	distinct	ADJ
fnp-8974	24	120	global	global	ADJ
fnp-8974	24	121	dna	dna	PROPN
fnp-8974	24	122	methylation	methylation	NOUN
fnp-8974	24	123	and	and	CCONJ
fnp-8974	24	124	sh3tc2	sh3tc2	NOUN
fnp-8974	24	125	fusions	fusion	NOUN
fnp-8974	24	126	p33	p33	NOUN
fnp-8974	25	1	ttf-1	ttf-1	NOUN
fnp-8974	25	2	expression	expression	NOUN
fnp-8974	25	3	is	be	AUX
fnp-8974	25	4	associated	associate	VERB
fnp-8974	25	5	with	with	ADP
fnp-8974	25	6	a	a	DET
fnp-8974	25	7	hypomethylation	hypomethylation	NOUN
fnp-8974	25	8	signature	signature	NOUN
fnp-8974	25	9	in	in	ADP
fnp-8974	25	10	schwannomas	schwannomas	PROPN
fnp-8974	25	11	p34	p34	NOUN
fnp-8974	25	12	expansion	expansion	NOUN
fnp-8974	25	13	of	of	ADP
fnp-8974	25	14	the	the	DET
fnp-8974	25	15	spectrum	spectrum	NOUN
fnp-8974	25	16	of	of	ADP
fnp-8974	25	17	tumors	tumor	NOUN
fnp-8974	25	18	diagnosed	diagnose	VERB
fnp-8974	25	19	as	as	ADP
fnp-8974	25	20	myxopapillary	myxopapillary	ADJ
fnp-8974	25	21	ependymomas	ependymomas	PROPN
fnp-8974	25	22	p35	p35	PROPN
fnp-8974	25	23	addressing	address	VERB
fnp-8974	25	24	mgmt	mgmt	NOUN
fnp-8974	25	25	activity	activity	NOUN
fnp-8974	25	26	in	in	ADP
fnp-8974	25	27	glial	glial	ADJ
fnp-8974	25	28	cell	cell	NOUN
fnp-8974	25	29	lines	line	NOUN
fnp-8974	25	30	p36	p36	NOUN
fnp-8974	25	31	loss	loss	NOUN
fnp-8974	25	32	of	of	ADP
fnp-8974	25	33	global	global	ADJ
fnp-8974	25	34	dna	dna	PROPN
fnp-8974	25	35	methylation	methylation	NOUN
fnp-8974	25	36	is	be	AUX
fnp-8974	25	37	prognostic	prognostic	ADJ
fnp-8974	25	38	in	in	ADP
fnp-8974	25	39	oligodendrogliomas	oligodendroglioma	NOUN
fnp-8974	25	40	p37	p37	NOUN
fnp-8974	25	41	leveraging	leverage	VERB
fnp-8974	25	42	peptide	peptide	NOUN
fnp-8974	25	43	-	-	PUNCT
fnp-8974	25	44	level	level	NOUN
fnp-8974	25	45	proteomics	proteomic	NOUN
fnp-8974	25	46	to	to	PART
fnp-8974	25	47	detect	detect	VERB
fnp-8974	25	48	brain	brain	NOUN
fnp-8974	25	49	cancer	cancer	NOUN
fnp-8974	25	50	specific	specific	ADJ
fnp-8974	25	51	proteoforms	proteoform	NOUN
fnp-8974	25	52	p38	p38	NOUN
fnp-8974	25	53	glioblastoma	glioblastoma	NOUN
fnp-8974	25	54	-	-	PUNCT
fnp-8974	25	55	derived	derive	VERB
fnp-8974	25	56	secreted	secrete	VERB
fnp-8974	25	57	proteins	protein	NOUN
fnp-8974	25	58	drive	drive	NOUN
fnp-8974	25	59	invasion	invasion	NOUN
fnp-8974	25	60	and	and	CCONJ
fnp-8974	25	61	affect	affect	VERB
fnp-8974	25	62	neuronal	neuronal	ADJ
fnp-8974	25	63	integrity	integrity	NOUN
fnp-8974	25	64	p39	p39	ADJ
fnp-8974	25	65	establishment	establishment	NOUN
fnp-8974	25	66	of	of	ADP
fnp-8974	25	67	droplet	droplet	ADJ
fnp-8974	25	68	digital	digital	ADJ
fnp-8974	25	69	™	™	ADJ
fnp-8974	25	70	pcr	pcr	NOUN
fnp-8974	25	71	(	(	PUNCT
fnp-8974	25	72	ddpcr	ddpcr	NOUN
fnp-8974	25	73	™	™	VERB
fnp-8974	25	74	)-based	)-base	VERB
fnp-8974	25	75	assays	assay	NOUN
fnp-8974	25	76	for	for	ADP
fnp-8974	25	77	the	the	DET
fnp-8974	25	78	diagnostic	diagnostic	ADJ
fnp-8974	25	79	detection	detection	NOUN
fnp-8974	25	80	of	of	ADP
fnp-8974	25	81	mgmt	mgmt	PROPN
fnp-8974	25	82	promoter	promoter	NOUN
fnp-8974	25	83	methylation	methylation	NOUN
fnp-8974	25	84	in	in	ADP
fnp-8974	25	85	malignant	malignant	ADJ
fnp-8974	25	86	gliomas	glioma	NOUN
fnp-8974	25	87	p40	p40	NOUN
fnp-8974	25	88	exploring	explore	VERB
fnp-8974	25	89	glioblastoma	glioblastoma	NOUN
fnp-8974	25	90	through	through	ADP
fnp-8974	25	91	cpg	cpg	PROPN
fnp-8974	25	92	site	site	NOUN
fnp-8974	25	93	-	-	PUNCT
fnp-8974	25	94	specific	specific	ADJ
fnp-8974	25	95	methylation	methylation	NOUN
fnp-8974	25	96	and	and	CCONJ
fnp-8974	25	97	transcription	transcription	NOUN
fnp-8974	25	98	factor	factor	NOUN
fnp-8974	25	99	occupancy	occupancy	NOUN
fnp-8974	25	100	p41	p41	PROPN
fnp-8974	25	101	integrated	integrate	VERB
fnp-8974	25	102	analyses	analysis	NOUN
fnp-8974	25	103	reveal	reveal	VERB
fnp-8974	25	104	four	four	NUM
fnp-8974	25	105	distinct	distinct	ADJ
fnp-8974	25	106	molecular	molecular	ADJ
fnp-8974	25	107	subgroups	subgroup	NOUN
fnp-8974	25	108	in	in	ADP
fnp-8974	25	109	corticotroph	corticotroph	ADJ
fnp-8974	25	110	pituitary	pituitary	ADJ
fnp-8974	25	111	neuroendocrine	neuroendocrine	NOUN
fnp-8974	25	112	tumors	tumor	NOUN
fnp-8974	25	113	/	/	SYM
fnp-8974	25	114	adenomas	adenomas	PROPN
fnp-8974	25	115	p42	p42	NOUN
fnp-8974	25	116	harnessing	harness	VERB
fnp-8974	25	117	stress	stress	ADJ
fnp-8974	25	118	adaptive	adaptive	ADJ
fnp-8974	25	119	response	response	NOUN
fnp-8974	25	120	mechanisms	mechanism	NOUN
fnp-8974	25	121	for	for	ADP
fnp-8974	25	122	pharmacological	pharmacological	ADJ
fnp-8974	25	123	targeting	targeting	NOUN
fnp-8974	25	124	of	of	ADP
fnp-8974	25	125	cancer	cancer	NOUN
fnp-8974	25	126	p43	p43	PROPN
fnp-8974	25	127	mechanisms	mechanism	NOUN
fnp-8974	25	128	of	of	ADP
fnp-8974	25	129	transformation	transformation	NOUN
fnp-8974	25	130	from	from	ADP
fnp-8974	25	131	subependymoma	subependymoma	NOUN
fnp-8974	25	132	to	to	PART
fnp-8974	25	133	ependymoma	ependymoma	VERB
fnp-8974	25	134	p44	p44	NOUN
fnp-8974	25	135	leveraging	leverage	VERB
fnp-8974	25	136	off	off	ADP
fnp-8974	25	137	-	-	PUNCT
fnp-8974	25	138	target	target	NOUN
fnp-8974	25	139	reads	read	NOUN
fnp-8974	25	140	for	for	ADP
fnp-8974	25	141	genome	genome	NOUN
fnp-8974	25	142	-	-	PUNCT
fnp-8974	25	143	wide	wide	ADJ
fnp-8974	25	144	copy	copy	NOUN
fnp-8974	25	145	number	number	NOUN
fnp-8974	25	146	profiling	profiling	NOUN
fnp-8974	25	147	in	in	ADP
fnp-8974	25	148	ngs	ng	NOUN
fnp-8974	25	149	panels	panel	NOUN
fnp-8974	25	150	p45	p45	PROPN
fnp-8974	25	151	establishing	establish	VERB
fnp-8974	25	152	ultra	ultra	ADJ
fnp-8974	25	153	low	low	ADJ
fnp-8974	25	154	-	-	PUNCT
fnp-8974	25	155	input	input	NOUN
fnp-8974	25	156	spatial	spatial	ADJ
fnp-8974	25	157	proteomics	proteomic	NOUN
fnp-8974	25	158	for	for	ADP
fnp-8974	25	159	glioblastoma	glioblastoma	NOUN
fnp-8974	25	160	analysis	analysis	NOUN
fnp-8974	25	161	p46	p46	ADJ
fnp-8974	25	162	comparison	comparison	NOUN
fnp-8974	25	163	of	of	ADP
fnp-8974	25	164	diffuse	diffuse	ADJ
fnp-8974	25	165	glioma	glioma	NOUN
fnp-8974	25	166	types	type	NOUN
fnp-8974	25	167	with	with	ADP
fnp-8974	25	168	gliomatosis	gliomatosis	NOUN
fnp-8974	25	169	cerebri	cerebri	NOUN
fnp-8974	25	170	growth	growth	NOUN
fnp-8974	25	171	pattern	pattern	NOUN
fnp-8974	25	172	in	in	ADP
fnp-8974	25	173	adult	adult	NOUN
fnp-8974	25	174	patients	patient	NOUN
fnp-8974	25	175	p47	p47	NUM
fnp-8974	25	176	immunohistochemical	immunohistochemical	ADJ
fnp-8974	25	177	expression	expression	NOUN
fnp-8974	25	178	and	and	CCONJ
fnp-8974	25	179	differential	differential	ADJ
fnp-8974	25	180	methylation	methylation	NOUN
fnp-8974	25	181	of	of	ADP
fnp-8974	25	182	hoxb13	hoxb13	NOUN
fnp-8974	25	183	reliably	reliably	ADV
fnp-8974	25	184	distinguishes	distinguish	VERB
fnp-8974	25	185	myxopapillary	myxopapillary	ADJ
fnp-8974	25	186	ependymoma	ependymoma	NOUN
fnp-8974	25	187	from	from	ADP
fnp-8974	25	188	spinal	spinal	ADJ
fnp-8974	25	189	ependymoma	ependymoma	NOUN
fnp-8974	25	190	p48	p48	NOUN
fnp-8974	25	191	spatial	spatial	ADJ
fnp-8974	25	192	mapping	mapping	NOUN
fnp-8974	25	193	of	of	ADP
fnp-8974	25	194	immunogenic	immunogenic	ADJ
fnp-8974	25	195	niches	niche	NOUN
fnp-8974	25	196	in	in	ADP
fnp-8974	25	197	melanoma	melanoma	NOUN
fnp-8974	25	198	brain	brain	NOUN
fnp-8974	25	199	metastases	metastasis	NOUN
fnp-8974	25	200	p49	p49	ADJ
fnp-8974	25	201	targeting	targeting	NOUN
fnp-8974	25	202	phosphorylation	phosphorylation	NOUN
fnp-8974	25	203	events	event	NOUN
fnp-8974	25	204	in	in	ADP
fnp-8974	25	205	glioblastoma	glioblastoma	NOUN
fnp-8974	25	206	:	:	PUNCT
fnp-8974	25	207	a	a	DET
fnp-8974	25	208	semi	semi	ADJ
fnp-8974	25	209	-	-	ADJ
fnp-8974	25	210	spatial	spatial	ADJ
fnp-8974	25	211	(	(	PUNCT
fnp-8974	25	212	phospho)proteomic	phospho)proteomic	ADJ
fnp-8974	25	213	workflow	workflow	NOUN
fnp-8974	25	214	for	for	ADP
fnp-8974	25	215	diffuse	diffuse	ADJ
fnp-8974	25	216	glioma	glioma	NOUN
fnp-8974	25	217	ffpe	ffpe	NOUN
fnp-8974	25	218	samples	sample	NOUN
fnp-8974	25	219	p50	p50	NOUN
fnp-8974	25	220	meningioma	meningioma	NOUN
fnp-8974	25	221	sanity	sanity	NOUN
fnp-8974	25	222	check	check	NOUN
fnp-8974	25	223	:	:	PUNCT
fnp-8974	25	224	increasing	increase	VERB
fnp-8974	25	225	classifier	classifier	NOUN
fnp-8974	25	226	credibility	credibility	NOUN
fnp-8974	25	227	through	through	ADP
fnp-8974	25	228	prototypical	prototypical	ADJ
fnp-8974	25	229	feature	feature	NOUN
fnp-8974	25	230	statistics	statistic	NOUN
fnp-8974	25	231	congress	congress	PROPN
fnp-8974	25	232	ids	id	VERB
fnp-8974	25	233	abstract	abstract	NOUN
fnp-8974	26	1	i	i	PROPN
fnp-8974	26	2	d	d	PROPN
fnp-8974	26	3	p	p	PROPN
fnp-8974	26	4	name	name	NOUN
fnp-8974	26	5	abstract	abstract	NOUN
fnp-8974	26	6	i	i	PROPN
fnp-8974	26	7	d	d	PROPN
fnp-8974	26	8	p	p	PROPN
fnp-8974	26	9	name	name	NOUN
fnp-8974	26	10	18	18	NUM
fnp-8974	26	11	p28	p28	NOUN
fnp-8974	26	12	lea	lea	PROPN
fnp-8974	26	13	altendorf	altendorf	PROPN
fnp-8974	26	14	,	,	PUNCT
fnp-8974	26	15	hamburg	hamburg	PROPN
fnp-8974	26	16	72	72	NUM
fnp-8974	26	17	p40	p40	NOUN
fnp-8974	26	18	kimia	kimia	NOUN
fnp-8974	26	19	kafi	kafi	PROPN
fnp-8974	26	20	cheraghi	cheraghi	PROPN
fnp-8974	26	21	,	,	PUNCT
fnp-8974	26	22	frankfurt	frankfurt	PROPN
fnp-8974	26	23	27	27	NUM
fnp-8974	26	24	p29	p29	PROPN
fnp-8974	26	25	natalie	natalie	PROPN
fnp-8974	26	26	berghaus	berghaus	PROPN
fnp-8974	26	27	,	,	PUNCT
fnp-8974	26	28	heidelberg	heidelberg	PROPN
fnp-8974	26	29	73	73	NUM
fnp-8974	26	30	p41	p41	PROPN
fnp-8974	26	31	matthias	matthias	PROPN
fnp-8974	26	32	dottermusch	dottermusch	PROPN
fnp-8974	26	33	,	,	PUNCT
fnp-8974	26	34	hamburg	hamburg	PROPN
fnp-8974	26	35	37	37	NUM
fnp-8974	26	36	p04	p04	PROPN
fnp-8974	26	37	paul	paul	PROPN
fnp-8974	26	38	kerbs	kerbs	PROPN
fnp-8974	26	39	,	,	PUNCT
fnp-8974	26	40	heidelberg	heidelberg	PROPN
fnp-8974	26	41	74	74	NUM
fnp-8974	26	42	p42	p42	PROPN
fnp-8974	26	43	laura	laura	NOUN
fnp-8974	26	44	hruby	hruby	PROPN
fnp-8974	26	45	,	,	PUNCT
fnp-8974	26	46	düsseldorf	düsseldorf	PROPN
fnp-8974	26	47	38	38	NUM
fnp-8974	26	48	p15	p15	PROPN
fnp-8974	26	49	ida	ida	PROPN
fnp-8974	26	50	vogt	vogt	PROPN
fnp-8974	26	51	,	,	PUNCT
fnp-8974	26	52	frankfurt	frankfurt	PROPN
fnp-8974	26	53	75	75	NUM
fnp-8974	26	54	p19	p19	NOUN
fnp-8974	26	55	valérie	valérie	ADJ
fnp-8974	26	56	quinot	quinot	NOUN
fnp-8974	26	57	,	,	PUNCT
fnp-8974	26	58	wien	wien	PROPN
fnp-8974	26	59	39	39	NUM
fnp-8974	26	60	p30	p30	NOUN
fnp-8974	26	61	catena	catena	PROPN
fnp-8974	26	62	kresbach	kresbach	PROPN
fnp-8974	26	63	,	,	PUNCT
fnp-8974	26	64	hamburg	hamburg	PROPN
fnp-8974	26	65	82	82	NUM
fnp-8974	26	66	p43	p43	PROPN
fnp-8974	26	67	hannah	hannah	PROPN
fnp-8974	26	68	jessner	jessner	PROPN
fnp-8974	26	69	,	,	PUNCT
fnp-8974	26	70	münster	münster	NOUN
fnp-8974	26	71	43	43	NUM
fnp-8974	26	72	p16	p16	PROPN
fnp-8974	26	73	helena	helena	PROPN
fnp-8974	26	74	radbruch	radbruch	PROPN
fnp-8974	26	75	,	,	PUNCT
fnp-8974	26	76	berlin	berlin	PROPN
fnp-8974	26	77	84	84	NUM
fnp-8974	26	78	p44	p44	NOUN
fnp-8974	26	79	christian	christian	PROPN
fnp-8974	26	80	thomas	thomas	PROPN
fnp-8974	26	81	,	,	PUNCT
fnp-8974	26	82	münster	münster	NOUN
fnp-8974	26	83	44	44	NUM
fnp-8974	26	84	p17	p17	NOUN
fnp-8974	27	1	imke	imke	INTJ
fnp-8974	27	2	metz	metz	PROPN
fnp-8974	27	3	,	,	PUNCT
fnp-8974	27	4	göttingen	göttingen	VERB
fnp-8974	27	5	85	85	NUM
fnp-8974	27	6	p25	p25	NOUN
fnp-8974	27	7	anna	anna	NOUN
fnp-8974	27	8	klötergens	klötergen	NOUN
fnp-8974	27	9	,	,	PUNCT
fnp-8974	27	10	münster	münster	NOUN
fnp-8974	27	11	45	45	NUM
fnp-8974	27	12	p24	p24	PROPN
fnp-8974	27	13	natalie	natalie	PROPN
fnp-8974	27	14	schoebe	schoebe	PROPN
fnp-8974	27	15	,	,	PUNCT
fnp-8974	27	16	heidelberg	heidelberg	PROPN
fnp-8974	27	17	86	86	NUM
fnp-8974	27	18	p45	p45	PROPN
fnp-8974	27	19	rhaissa	rhaissa	PROPN
fnp-8974	27	20	ribeiro	ribeiro	PROPN
fnp-8974	27	21	da	da	PROPN
fnp-8974	27	22	silva	silva	PROPN
fnp-8974	27	23	,	,	PUNCT
fnp-8974	27	24	heidelberg	heidelberg	PROPN
fnp-8974	27	25	46	46	NUM
fnp-8974	27	26	p31	p31	PROPN
fnp-8974	27	27	antonia	antonia	PROPN
fnp-8974	27	28	gocke	gocke	PROPN
fnp-8974	27	29	,	,	PUNCT
fnp-8974	27	30	hamburg	hamburg	PROPN
fnp-8974	27	31	87	87	NUM
fnp-8974	27	32	p46	p46	PROPN
fnp-8974	27	33	marco	marco	PROPN
fnp-8974	27	34	münzberg	münzberg	PROPN
fnp-8974	27	35	,	,	PUNCT
fnp-8974	27	36	frankfurt	frankfurt	PROPN
fnp-8974	27	37	47	47	NUM
fnp-8974	27	38	p32	p32	PROPN
fnp-8974	27	39	helena	helena	PROPN
fnp-8974	27	40	bode	bode	PROPN
fnp-8974	27	41	,	,	PUNCT
fnp-8974	27	42	hamburg	hamburg	PROPN
fnp-8974	27	43	88	88	NUM
fnp-8974	27	44	p47	p47	PROPN
fnp-8974	27	45	suvendu	suvendu	NOUN
fnp-8974	27	46	purkait	purkait	NOUN
fnp-8974	27	47	,	,	PUNCT
fnp-8974	27	48	düsseldorf	düsseldorf	PROPN
fnp-8974	27	49	52	52	NUM
fnp-8974	27	50	p07	p07	PROPN
fnp-8974	27	51	dorothea	dorothea	PROPN
fnp-8974	27	52	münch	münch	NOUN
fnp-8974	27	53	,	,	PUNCT
fnp-8974	27	54	frankfurt	frankfurt	PROPN
fnp-8974	27	55	89	89	NUM
fnp-8974	27	56	p20	p20	NOUN
fnp-8974	27	57	laura	laura	PROPN
fnp-8974	27	58	schmitz	schmitz	PROPN
fnp-8974	27	59	-	-	PUNCT
fnp-8974	27	60	gielsdorf	gielsdorf	PROPN
fnp-8974	27	61	,	,	PUNCT
fnp-8974	27	62	münster	münster	NOUN
fnp-8974	27	63	53	53	NUM
fnp-8974	27	64	p10	p10	PROPN
fnp-8974	27	65	antonia	antonia	PROPN
fnp-8974	27	66	neubauer	neubauer	PROPN
fnp-8974	27	67	,	,	PUNCT
fnp-8974	27	68	münchen	münchen	PROPN
fnp-8974	27	69	90	90	NUM
fnp-8974	27	70	p21	p21	PROPN
fnp-8974	27	71	lidia	lidia	PROPN
fnp-8974	27	72	stork	stork	PROPN
fnp-8974	27	73	,	,	PUNCT
fnp-8974	27	74	göttingen	göttingen	VERB
fnp-8974	27	75	56	56	NUM
fnp-8974	27	76	p11	p11	ADJ
fnp-8974	27	77	viktoria	viktoria	PROPN
fnp-8974	27	78	ruf	ruf	NOUN
fnp-8974	27	79	,	,	PUNCT
fnp-8974	27	80	münchen	münchen	PROPN
fnp-8974	27	81	91	91	NUM
fnp-8974	27	82	p05	p05	PROPN
fnp-8974	27	83	jannik	jannik	PROPN
fnp-8974	27	84	sehring	sehring	NOUN
fnp-8974	27	85	,	,	PUNCT
fnp-8974	27	86	gießen	gießen	PROPN
fnp-8974	27	87	57	57	NUM
fnp-8974	27	88	p33	p33	NOUN
fnp-8974	27	89	max	max	PROPN
fnp-8974	27	90	braune	braune	PROPN
fnp-8974	27	91	,	,	PUNCT
fnp-8974	27	92	leipzig	leipzig	NOUN
fnp-8974	27	93	93	93	NUM
fnp-8974	27	94	p22	p22	NOUN
fnp-8974	27	95	frank	frank	PROPN
fnp-8974	27	96	heppner	heppner	PROPN
fnp-8974	27	97	,	,	PUNCT
fnp-8974	27	98	berlin	berlin	PROPN
fnp-8974	27	99	58	58	NUM
fnp-8974	27	100	p34	p34	NOUN
fnp-8974	27	101	fuat	fuat	PROPN
fnp-8974	27	102	aras	aras	PROPN
fnp-8974	27	103	,	,	PUNCT
fnp-8974	27	104	heidelberg	heidelberg	NOUN
fnp-8974	27	105	95	95	NUM
fnp-8974	27	106	p48	p48	NOUN
fnp-8974	27	107	josefine	josefine	PROPN
fnp-8974	27	108	radke	radke	PROPN
fnp-8974	27	109	,	,	PUNCT
fnp-8974	27	110	greifswald	greifswald	PROPN
fnp-8974	27	111	60	60	NUM
fnp-8974	27	112	p12	p12	PROPN
fnp-8974	27	113	marina	marina	PROPN
fnp-8974	27	114	jendrach	jendrach	PROPN
fnp-8974	27	115	,	,	PUNCT
fnp-8974	28	1	berlin	berlin	PROPN
fnp-8974	28	2	96	96	NUM
fnp-8974	28	3	p23	p23	NOUN
fnp-8974	28	4	imke	imke	PROPN
fnp-8974	28	5	metz	metz	PROPN
fnp-8974	28	6	,	,	PUNCT
fnp-8974	28	7	göttingen	göttingen	VERB
fnp-8974	28	8	62	62	NUM
fnp-8974	28	9	p01	p01	NOUN
fnp-8974	28	10	antonia	antonia	PROPN
fnp-8974	28	11	gocke	gocke	PROPN
fnp-8974	28	12	,	,	PUNCT
fnp-8974	28	13	hamburg	hamburg	PROPN
fnp-8974	28	14	97	97	NUM
fnp-8974	28	15	p02	p02	PROPN
fnp-8974	28	16	anika	anika	PROPN
fnp-8974	28	17	simonovska	simonovska	PROPN
fnp-8974	28	18	serra	serra	PROPN
fnp-8974	28	19	,	,	PUNCT
fnp-8974	28	20	wien	wien	PROPN
fnp-8974	28	21	63	63	NUM
fnp-8974	28	22	p35	p35	PROPN
fnp-8974	28	23	helene	helene	NOUN
fnp-8974	28	24	blatt	blatt	PROPN
fnp-8974	28	25	,	,	PUNCT
fnp-8974	28	26	homburg	homburg	PROPN
fnp-8974	28	27	98	98	NUM
fnp-8974	28	28	p49	p49	PROPN
fnp-8974	28	29	gianluca	gianluca	PROPN
fnp-8974	28	30	sigismondo	sigismondo	PROPN
fnp-8974	28	31	,	,	PUNCT
fnp-8974	28	32	heidelberg	heidelberg	PROPN
fnp-8974	28	33	64	64	NUM
fnp-8974	28	34	p36	p36	PROPN
fnp-8974	28	35	felix	felix	PROPN
fnp-8974	28	36	hinz	hinz	PROPN
fnp-8974	28	37	,	,	PUNCT
fnp-8974	28	38	heidelberg	heidelberg	NOUN
fnp-8974	28	39	99	99	NUM
fnp-8974	28	40	p50	p50	PROPN
fnp-8974	28	41	kai	kai	PROPN
fnp-8974	28	42	schmid	schmid	PROPN
fnp-8974	28	43	,	,	PUNCT
fnp-8974	28	44	gießen	gießen	PROPN
fnp-8974	28	45	65	65	NUM
fnp-8974	28	46	p37	p37	NOUN
fnp-8974	28	47	ian	ian	PROPN
fnp-8974	28	48	fichtner	fichtner	NOUN
fnp-8974	28	49	,	,	PUNCT
fnp-8974	28	50	heidelberg	heidelberg	NOUN
fnp-8974	28	51	100	100	NUM
fnp-8974	28	52	p26	p26	PROPN
fnp-8974	28	53	charlotte	charlotte	PROPN
fnp-8974	28	54	brandenburg	brandenburg	PROPN
fnp-8974	28	55	,	,	PUNCT
fnp-8974	28	56	frankfurt	frankfurt	PROPN
fnp-8974	28	57	66	66	NUM
fnp-8974	28	58	p08	p08	PROPN
fnp-8974	28	59	selin	selin	PROPN
fnp-8974	28	60	kanarya	kanarya	PROPN
fnp-8974	28	61	,	,	PUNCT
fnp-8974	28	62	düsseldorf	düsseldorf	PROPN
fnp-8974	28	63	101	101	NUM
fnp-8974	28	64	p06	p06	PROPN
fnp-8974	28	65	kiana	kiana	PROPN
fnp-8974	28	66	kafi	kafi	PROPN
fnp-8974	28	67	cheraghi	cheraghi	PROPN
fnp-8974	28	68	,	,	PUNCT
fnp-8974	28	69	frankfurt	frankfurt	PROPN
fnp-8974	28	70	67	67	NUM
fnp-8974	28	71	p38	p38	NOUN
fnp-8974	28	72	tanja	tanja	NOUN
fnp-8974	28	73	buhlmann	buhlmann	NOUN
fnp-8974	28	74	,	,	PUNCT
fnp-8974	28	75	frankfurt	frankfurt	PROPN
fnp-8974	28	76	102	102	NUM
fnp-8974	28	77	p09	p09	PROPN
fnp-8974	28	78	paula	paula	PROPN
fnp-8974	28	79	pereira	pereira	PROPN
fnp-8974	28	80	de	de	PROPN
fnp-8974	28	81	almeida	almeida	PROPN
fnp-8974	28	82	,	,	PUNCT
fnp-8974	28	83	essen	essen	VERB
fnp-8974	28	84	68	68	NUM
fnp-8974	28	85	p39	p39	ADJ
fnp-8974	28	86	marietta	marietta	PROPN
fnp-8974	28	87	wolter	wolter	NOUN
fnp-8974	28	88	,	,	PUNCT
fnp-8974	28	89	düsseldorf	düsseldorf	PROPN
fnp-8974	28	90	105	105	NUM
fnp-8974	28	91	p14	p14	PROPN
fnp-8974	28	92	maximilien	maximilien	PROPN
fnp-8974	28	93	lépine	lépine	NOUN
fnp-8974	28	94	,	,	PUNCT
fnp-8974	28	95	gießen	gießen	VERB
fnp-8974	28	96	69	69	NUM
fnp-8974	28	97	p18	p18	NOUN
fnp-8974	28	98	raphael	raphael	PROPN
fnp-8974	28	99	raspe	raspe	PROPN
fnp-8974	28	100	,	,	PUNCT
fnp-8974	28	101	berlin	berlin	PROPN
fnp-8974	28	102	107	107	NUM
fnp-8974	28	103	p27	p27	PROPN
fnp-8974	28	104	willy	willy	PROPN
fnp-8974	28	105	hube	hube	PROPN
fnp-8974	28	106	,	,	PUNCT
fnp-8974	28	107	münchen	münchen	NOUN
fnp-8974	28	108	70	70	NUM
fnp-8974	28	109	p13	p13	PROPN
fnp-8974	28	110	alberto	alberto	ADJ
fnp-8974	28	111	grassini	grassini	NOUN
fnp-8974	28	112	,	,	PUNCT
fnp-8974	28	113	tübingen	tübingen	PROPN
fnp-8974	28	114	108	108	NUM
fnp-8974	28	115	p03	p03	PROPN
fnp-8974	28	116	jan	jan	PROPN
fnp-8974	28	117	philip	philip	PROPN
fnp-8974	28	118	kolb	kolb	PROPN
fnp-8974	28	119	,	,	PUNCT
fnp-8974	28	120	hamburg	hamburg	PROPN
fnp-8974	28	121	i.	i.	PROPN
fnp-8974	28	122	artificial	artificial	PROPN
fnp-8974	28	123	intelligence	intelligence	NOUN
fnp-8974	28	124	p01	p01	NOUN
fnp-8974	28	125	free	free	ADJ
fnp-8974	28	126	neuropathol	neuropathol	NOUN
fnp-8974	28	127	6:17:6	6:17:6	NUM
fnp-8974	28	128	accurate	accurate	ADJ
fnp-8974	28	129	,	,	PUNCT
fnp-8974	28	130	inexpensive	inexpensive	ADJ
fnp-8974	28	131	&	&	CCONJ
fnp-8974	28	132	fast	fast	ADJ
fnp-8974	28	133	–	–	PUNCT
fnp-8974	28	134	computational	computational	ADJ
fnp-8974	28	135	pathology	pathology	NOUN
fnp-8974	28	136	for	for	ADP
fnp-8974	28	137	ependymoma	ependymoma	NOUN
fnp-8974	28	138	subtyping	subtype	VERB
fnp-8974	28	139	yannis	yannis	PROPN
fnp-8974	28	140	schumann1	schumann1	NOUN
fnp-8974	28	141	,	,	PUNCT
fnp-8974	28	142	maximilian	maximilian	PROPN
fnp-8974	28	143	middelkamp2	middelkamp2	PROPN
fnp-8974	28	144	,	,	PUNCT
fnp-8974	28	145	antonia	antonia	PROPN
fnp-8974	28	146	gocke3,4	gocke3,4	PROPN
fnp-8974	28	147	,	,	PUNCT
fnp-8974	28	148	jette	jette	PROPN
fnp-8974	28	149	alfken5	alfken5	PROPN
fnp-8974	28	150	,	,	PUNCT
fnp-8974	28	151	sarah	sarah	PROPN
fnp-8974	28	152	becker5	becker5	PROPN
fnp-8974	28	153	,	,	PUNCT
fnp-8974	28	154	tasja	tasja	PROPN
fnp-8974	28	155	lempertz3	lempertz3	PROPN
fnp-8974	28	156	,	,	PUNCT
fnp-8974	28	157	jennifer	jennifer	PROPN
fnp-8974	28	158	ahrens3	ahrens3	PROPN
fnp-8974	28	159	,	,	PUNCT
fnp-8974	28	160	karoline	karoline	PROPN
fnp-8974	28	161	hack6	hack6	PROPN
fnp-8974	28	162	,	,	PUNCT
fnp-8974	28	163	markus	markus	PROPN
fnp-8974	28	164	glatzel7	glatzel7	PROPN
fnp-8974	28	165	,	,	PUNCT
fnp-8974	28	166	claire	claire	PROPN
fnp-8974	28	167	ertelt	ertelt	PROPN
fnp-8974	28	168	-	-	PUNCT
fnp-8974	28	169	delbridge8	delbridge8	PROPN
fnp-8974	28	170	,	,	PUNCT
fnp-8974	28	171	ulrich	ulrich	PROPN
fnp-8974	28	172	schüller6,7,9	schüller6,7,9	PROPN
fnp-8974	28	173	,	,	PUNCT
fnp-8974	28	174	tim	tim	PROPN
fnp-8974	28	175	salditt5	salditt5	PROPN
fnp-8974	28	176	,	,	PUNCT
fnp-8974	28	177	julia	julia	PROPN
fnp-8974	28	178	neumann3,7	neumann3,7	PROPN
fnp-8974	28	179	1	1	NUM
fnp-8974	28	180	deutsches	deutsche	NOUN
fnp-8974	28	181	elektronen	elektronen	NOUN
fnp-8974	28	182	-	-	PUNCT
fnp-8974	28	183	synchrotron	synchrotron	NOUN
fnp-8974	28	184	desy	desy	NOUN
fnp-8974	28	185	,	,	PUNCT
fnp-8974	28	186	it	it	PRON
fnp-8974	28	187	department	department	NOUN
fnp-8974	28	188	,	,	PUNCT
fnp-8974	28	189	data	datum	NOUN
fnp-8974	28	190	management	management	NOUN
fnp-8974	28	191	and	and	CCONJ
fnp-8974	28	192	analysis	analysis	NOUN
fnp-8974	28	193	,	,	PUNCT
fnp-8974	28	194	hamburg	hamburg	PROPN
fnp-8974	28	195	,	,	PUNCT
fnp-8974	28	196	germany	germany	PROPN
fnp-8974	28	197	2department	2department	NUM
fnp-8974	28	198	of	of	ADP
fnp-8974	28	199	neurosurgery	neurosurgery	NOUN
fnp-8974	28	200	,	,	PUNCT
fnp-8974	28	201	university	university	NOUN
fnp-8974	28	202	medical	medical	ADJ
fnp-8974	28	203	center	center	PROPN
fnp-8974	28	204	hamburg	hamburg	PROPN
fnp-8974	28	205	-	-	PUNCT
fnp-8974	28	206	eppendorf	eppendorf	PROPN
fnp-8974	28	207	,	,	PUNCT
fnp-8974	28	208	hamburg	hamburg	PROPN
fnp-8974	28	209	,	,	PUNCT
fnp-8974	28	210	germany	germany	PROPN
fnp-8974	28	211	3	3	NUM
fnp-8974	28	212	center	center	NOUN
fnp-8974	28	213	for	for	ADP
fnp-8974	28	214	molecular	molecular	ADJ
fnp-8974	28	215	neurobiology	neurobiology	NOUN
fnp-8974	28	216	(	(	PUNCT
fnp-8974	28	217	zmnh	zmnh	NOUN
fnp-8974	28	218	)	)	PUNCT
fnp-8974	28	219	,	,	PUNCT
fnp-8974	28	220	university	university	NOUN
fnp-8974	28	221	medical	medical	ADJ
fnp-8974	28	222	center	center	PROPN
fnp-8974	28	223	hamburg	hamburg	PROPN
fnp-8974	28	224	-	-	PUNCT
fnp-8974	28	225	eppendorf	eppendorf	PROPN
fnp-8974	28	226	,	,	PUNCT
fnp-8974	28	227	hamburg	hamburg	PROPN
fnp-8974	28	228	,	,	PUNCT
fnp-8974	28	229	germany	germany	PROPN
fnp-8974	28	230	4	4	NUM
fnp-8974	28	231	section	section	NOUN
fnp-8974	28	232	of	of	ADP
fnp-8974	28	233	mass	mass	ADJ
fnp-8974	28	234	spectrometric	spectrometric	ADJ
fnp-8974	28	235	proteomics	proteomic	NOUN
fnp-8974	28	236	,	,	PUNCT
fnp-8974	28	237	university	university	NOUN
fnp-8974	28	238	medical	medical	ADJ
fnp-8974	28	239	center	center	PROPN
fnp-8974	28	240	hamburg	hamburg	PROPN
fnp-8974	28	241	-	-	PUNCT
fnp-8974	28	242	eppendorf	eppendorf	PROPN
fnp-8974	28	243	,	,	PUNCT
fnp-8974	28	244	hamburg	hamburg	PROPN
fnp-8974	28	245	,	,	PUNCT
fnp-8974	28	246	germany	germany	PROPN
fnp-8974	28	247	5	5	NUM
fnp-8974	28	248	institute	institute	PROPN
fnp-8974	28	249	for	for	ADP
fnp-8974	28	250	x	x	PROPN
fnp-8974	28	251	-	-	NOUN
fnp-8974	28	252	ray	ray	NOUN
fnp-8974	28	253	physics	physics	NOUN
fnp-8974	28	254	,	,	PUNCT
fnp-8974	28	255	university	university	NOUN
fnp-8974	28	256	of	of	ADP
fnp-8974	28	257	göttingen	göttingen	NOUN
fnp-8974	28	258	,	,	PUNCT
fnp-8974	28	259	göttingen	göttingen	NOUN
fnp-8974	28	260	,	,	PUNCT
fnp-8974	28	261	germany	germany	PROPN
fnp-8974	28	262	6	6	NUM
fnp-8974	28	263	children	child	NOUN
fnp-8974	28	264	’s	’s	PART
fnp-8974	28	265	cancer	cancer	NOUN
fnp-8974	28	266	research	research	PROPN
fnp-8974	28	267	center	center	PROPN
fnp-8974	28	268	hamburg	hamburg	PROPN
fnp-8974	28	269	,	,	PUNCT
fnp-8974	28	270	hamburg	hamburg	PROPN
fnp-8974	28	271	,	,	PUNCT
fnp-8974	28	272	germany	germany	PROPN
fnp-8974	28	273	7	7	NUM
fnp-8974	28	274	institute	institute	PROPN
fnp-8974	28	275	of	of	ADP
fnp-8974	28	276	neuropathology	neuropathology	NOUN
fnp-8974	28	277	,	,	PUNCT
fnp-8974	28	278	university	university	NOUN
fnp-8974	28	279	medical	medical	ADJ
fnp-8974	28	280	center	center	PROPN
fnp-8974	28	281	hamburg	hamburg	PROPN
fnp-8974	28	282	-	-	PUNCT
fnp-8974	28	283	eppendorf	eppendorf	PROPN
fnp-8974	28	284	,	,	PUNCT
fnp-8974	28	285	hamburg	hamburg	PROPN
fnp-8974	28	286	,	,	PUNCT
fnp-8974	28	287	germany	germany	PROPN
fnp-8974	28	288	8	8	PROPN
fnp-8974	28	289	institute	institute	PROPN
fnp-8974	28	290	of	of	ADP
fnp-8974	28	291	pathology	pathology	PROPN
fnp-8974	28	292	,	,	PUNCT
fnp-8974	28	293	school	school	NOUN
fnp-8974	28	294	of	of	ADP
fnp-8974	28	295	medicine	medicine	NOUN
fnp-8974	28	296	and	and	CCONJ
fnp-8974	28	297	health	health	NOUN
fnp-8974	28	298	,	,	PUNCT
fnp-8974	28	299	technical	technical	ADJ
fnp-8974	28	300	university	university	PROPN
fnp-8974	28	301	of	of	ADP
fnp-8974	28	302	munich	munich	PROPN
fnp-8974	28	303	,	,	PUNCT
fnp-8974	28	304	munich	munich	PROPN
fnp-8974	28	305	,	,	PUNCT
fnp-8974	28	306	germany	germany	PROPN
fnp-8974	28	307	9	9	NUM
fnp-8974	28	308	department	department	NOUN
fnp-8974	28	309	of	of	ADP
fnp-8974	28	310	pediatric	pediatric	ADJ
fnp-8974	28	311	hematology	hematology	NOUN
fnp-8974	28	312	and	and	CCONJ
fnp-8974	28	313	oncology	oncology	NOUN
fnp-8974	28	314	,	,	PUNCT
fnp-8974	28	315	university	university	NOUN
fnp-8974	28	316	medical	medical	ADJ
fnp-8974	28	317	center	center	PROPN
fnp-8974	28	318	hamburg	hamburg	PROPN
fnp-8974	28	319	-	-	PUNCT
fnp-8974	28	320	eppendorf	eppendorf	PROPN
fnp-8974	28	321	,	,	PUNCT
fnp-8974	28	322	hamburg	hamburg	PROPN
fnp-8974	28	323	,	,	PUNCT
fnp-8974	28	324	germany	germany	PROPN
fnp-8974	28	325	background	background	NOUN
fnp-8974	28	326	:	:	PUNCT
fnp-8974	29	1	ependymal	ependymal	ADJ
fnp-8974	29	2	tumours	tumours	PROPN
fnp-8974	29	3	(	(	PUNCT
fnp-8974	29	4	epns	epns	X
fnp-8974	29	5	)	)	PUNCT
fnp-8974	29	6	are	be	AUX
fnp-8974	29	7	clinically	clinically	ADV
fnp-8974	29	8	heterogeneous	heterogeneous	ADJ
fnp-8974	29	9	neoplasms	neoplasm	NOUN
fnp-8974	29	10	and	and	CCONJ
fnp-8974	29	11	can	can	AUX
fnp-8974	29	12	occur	occur	VERB
fnp-8974	29	13	in	in	ADP
fnp-8974	29	14	all	all	DET
fnp-8974	29	15	three	three	NUM
fnp-8974	29	16	compartments	compartment	NOUN
fnp-8974	29	17	of	of	ADP
fnp-8974	29	18	the	the	DET
fnp-8974	29	19	central	central	ADJ
fnp-8974	29	20	nervous	nervous	ADJ
fnp-8974	29	21	system	system	NOUN
fnp-8974	29	22	.	.	PUNCT
fnp-8974	30	1	the	the	DET
fnp-8974	30	2	2021	2021	NUM
fnp-8974	30	3	who	who	PRON
fnp-8974	30	4	classification	classification	NOUN
fnp-8974	30	5	defines	define	VERB
fnp-8974	30	6	10	10	NUM
fnp-8974	30	7	clinically	clinically	ADV
fnp-8974	30	8	distinct	distinct	ADJ
fnp-8974	30	9	types	type	NOUN
fnp-8974	30	10	of	of	ADP
fnp-8974	30	11	epns	epns	NOUN
fnp-8974	30	12	based	base	VERB
fnp-8974	30	13	on	on	ADP
fnp-8974	30	14	molecular	molecular	ADJ
fnp-8974	30	15	,	,	PUNCT
fnp-8974	30	16	anatomical	anatomical	ADJ
fnp-8974	30	17	and	and	CCONJ
fnp-8974	30	18	immunohistochemical	immunohistochemical	ADJ
fnp-8974	30	19	criteria	criterion	NOUN
fnp-8974	30	20	.	.	PUNCT
fnp-8974	31	1	objective(s	objective(s	NOUN
fnp-8974	31	2	):	):	PUNCT
fnp-8974	31	3	precise	precise	ADJ
fnp-8974	31	4	diagnoses	diagnosis	NOUN
fnp-8974	31	5	,	,	PUNCT
fnp-8974	31	6	such	such	ADJ
fnp-8974	31	7	as	as	ADP
fnp-8974	31	8	from	from	ADP
fnp-8974	31	9	dna	dna	PROPN
fnp-8974	31	10	methylation	methylation	NOUN
fnp-8974	31	11	analyses	analysis	NOUN
fnp-8974	31	12	,	,	PUNCT
fnp-8974	31	13	are	be	AUX
fnp-8974	31	14	crucial	crucial	ADJ
fnp-8974	31	15	for	for	ADP
fnp-8974	31	16	optimal	optimal	ADJ
fnp-8974	31	17	therapy	therapy	NOUN
fnp-8974	31	18	and	and	CCONJ
fnp-8974	31	19	patient	patient	ADJ
fnp-8974	31	20	outcome	outcome	NOUN
fnp-8974	31	21	.	.	PUNCT
fnp-8974	32	1	yet	yet	ADV
fnp-8974	32	2	,	,	PUNCT
fnp-8974	32	3	these	these	DET
fnp-8974	32	4	analyses	analysis	NOUN
fnp-8974	32	5	are	be	AUX
fnp-8974	32	6	time	time	NOUN
fnp-8974	32	7	consuming	consume	VERB
fnp-8974	32	8	and	and	CCONJ
fnp-8974	32	9	expensive	expensive	ADJ
fnp-8974	32	10	.	.	PUNCT
fnp-8974	33	1	we	we	PRON
fnp-8974	33	2	discuss	discuss	VERB
fnp-8974	33	3	multiple	multiple	ADJ
fnp-8974	33	4	machine	machine	NOUN
fnp-8974	33	5	-	-	PUNCT
fnp-8974	33	6	learning	learn	VERB
fnp-8974	33	7	methods	method	NOUN
fnp-8974	33	8	for	for	ADP
fnp-8974	33	9	computational	computational	ADJ
fnp-8974	33	10	pathology	pathology	NOUN
fnp-8974	33	11	of	of	ADP
fnp-8974	33	12	ependymomas	ependymomas	PROPN
fnp-8974	33	13	and	and	CCONJ
fnp-8974	33	14	highlight	highlight	VERB
fnp-8974	33	15	how	how	SCONJ
fnp-8974	33	16	such	such	ADJ
fnp-8974	33	17	approaches	approach	NOUN
fnp-8974	33	18	may	may	AUX
fnp-8974	33	19	act	act	VERB
fnp-8974	33	20	as	as	ADP
fnp-8974	33	21	an	an	DET
fnp-8974	33	22	inexpensive	inexpensive	ADJ
fnp-8974	33	23	and	and	CCONJ
fnp-8974	33	24	fast	fast	ADJ
fnp-8974	33	25	surrogate	surrogate	NOUN
fnp-8974	33	26	for	for	ADP
fnp-8974	33	27	molecular	molecular	ADJ
fnp-8974	33	28	analysis	analysis	NOUN
fnp-8974	33	29	.	.	PUNCT
fnp-8974	34	1	method(s	method(	VERB
fnp-8974	34	2	):	):	PUNCT
fnp-8974	34	3	whole	whole	ADJ
fnp-8974	34	4	-	-	PUNCT
fnp-8974	34	5	slide	slide	NOUN
fnp-8974	34	6	images	image	NOUN
fnp-8974	34	7	of	of	ADP
fnp-8974	34	8	tissues	tissue	NOUN
fnp-8974	34	9	with	with	ADP
fnp-8974	34	10	hematoxylin	hematoxylin	NOUN
fnp-8974	34	11	and	and	CCONJ
fnp-8974	34	12	eosin	eosin	NOUN
fnp-8974	34	13	stain	stain	NOUN
fnp-8974	34	14	were	be	AUX
fnp-8974	34	15	acquired	acquire	VERB
fnp-8974	34	16	and	and	CCONJ
fnp-8974	34	17	matched	match	VERB
fnp-8974	34	18	with	with	ADP
fnp-8974	34	19	dna	dna	PROPN
fnp-8974	34	20	methylation	methylation	NOUN
fnp-8974	34	21	profiles	profile	NOUN
fnp-8974	34	22	.	.	PUNCT
fnp-8974	35	1	interpretable	interpretable	ADJ
fnp-8974	35	2	machine	machine	NOUN
fnp-8974	35	3	-	-	PUNCT
fnp-8974	35	4	learning	learn	VERB
fnp-8974	35	5	methods	method	NOUN
fnp-8974	35	6	and	and	CCONJ
fnp-8974	35	7	multi	multi	ADJ
fnp-8974	35	8	-	-	ADJ
fnp-8974	35	9	scale	scale	ADJ
fnp-8974	35	10	approaches	approach	NOUN
fnp-8974	35	11	were	be	AUX
fnp-8974	35	12	used	use	VERB
fnp-8974	35	13	to	to	PART
fnp-8974	35	14	predict	predict	VERB
fnp-8974	35	15	dna	dna	PROPN
fnp-8974	35	16	-	-	PUNCT
fnp-8974	35	17	methylation	methylation	NOUN
fnp-8974	35	18	types	type	NOUN
fnp-8974	35	19	from	from	ADP
fnp-8974	35	20	image	image	NOUN
fnp-8974	35	21	data	datum	NOUN
fnp-8974	35	22	.	.	PUNCT
fnp-8974	36	1	stacking	stacking	NOUN
fnp-8974	36	2	was	be	AUX
fnp-8974	36	3	used	use	VERB
fnp-8974	36	4	to	to	PART
fnp-8974	36	5	incorporate	incorporate	VERB
fnp-8974	36	6	basic	basic	ADJ
fnp-8974	36	7	clinical	clinical	ADJ
fnp-8974	36	8	information	information	NOUN
fnp-8974	36	9	(	(	PUNCT
fnp-8974	36	10	e.g.	e.g.	ADV
fnp-8974	36	11	sex	sex	NOUN
fnp-8974	36	12	,	,	PUNCT
fnp-8974	36	13	age	age	NOUN
fnp-8974	36	14	,	,	PUNCT
fnp-8974	36	15	location	location	NOUN
fnp-8974	36	16	)	)	PUNCT
fnp-8974	36	17	.	.	PUNCT
fnp-8974	37	1	result(s	result(s	PROPN
fnp-8974	37	2	):	):	PUNCT
fnp-8974	37	3	we	we	PRON
fnp-8974	37	4	acquired	acquire	VERB
fnp-8974	37	5	a	a	DET
fnp-8974	37	6	cohort	cohort	NOUN
fnp-8974	37	7	of	of	ADP
fnp-8974	37	8	sample	sample	NOUN
fnp-8974	37	9	-	-	PUNCT
fnp-8974	37	10	matched	match	VERB
fnp-8974	37	11	h&e	h&e	PROPN
fnp-8974	37	12	wsis	wsis	NOUN
fnp-8974	37	13	and	and	CCONJ
fnp-8974	37	14	dna	dna	NOUN
fnp-8974	37	15	-	-	PUNCT
fnp-8974	37	16	methylation	methylation	NOUN
fnp-8974	37	17	analyses	analysis	NOUN
fnp-8974	37	18	of	of	ADP
fnp-8974	37	19	epn	epn	PROPN
fnp-8974	37	20	(	(	PUNCT
fnp-8974	37	21	n	n	CCONJ
fnp-8974	37	22	 	 	SPACE
fnp-8974	37	23	=	=	NOUN
fnp-8974	37	24	 	 	SPACE
fnp-8974	37	25	597	597	NUM
fnp-8974	37	26	)	)	PUNCT
fnp-8974	37	27	.	.	PUNCT
fnp-8974	38	1	while	while	SCONJ
fnp-8974	38	2	both	both	DET
fnp-8974	38	3	clam	clam	PROPN
fnp-8974	38	4	(	(	PUNCT
fnp-8974	38	5	clustering	cluster	VERB
fnp-8974	38	6	-	-	PUNCT
fnp-8974	38	7	constrained	constrain	VERB
fnp-8974	38	8	attention	attention	NOUN
fnp-8974	38	9	multiple	multiple	ADJ
fnp-8974	38	10	instance	instance	NOUN
fnp-8974	38	11	learning	learn	VERB
fnp-8974	38	12	)	)	PUNCT
fnp-8974	38	13	and	and	CCONJ
fnp-8974	38	14	hipt	hipt	NOUN
fnp-8974	38	15	(	(	PUNCT
fnp-8974	38	16	hierarchical	hierarchical	ADJ
fnp-8974	38	17	image	image	NOUN
fnp-8974	38	18	pyramid	pyramid	NOUN
fnp-8974	38	19	transformers	transformer	NOUN
fnp-8974	38	20	)	)	PUNCT
fnp-8974	38	21	showed	show	VERB
fnp-8974	38	22	near	near	ADP
fnp-8974	38	23	perfect	perfect	ADJ
fnp-8974	38	24	classification	classification	NOUN
fnp-8974	38	25	results	result	NOUN
fnp-8974	38	26	when	when	SCONJ
fnp-8974	38	27	incorporating	incorporate	VERB
fnp-8974	38	28	clinical	clinical	ADJ
fnp-8974	38	29	variables	variable	NOUN
fnp-8974	38	30	,	,	PUNCT
fnp-8974	38	31	our	our	PRON
fnp-8974	38	32	results	result	NOUN
fnp-8974	38	33	indicate	indicate	VERB
fnp-8974	38	34	that	that	SCONJ
fnp-8974	38	35	the	the	DET
fnp-8974	38	36	hipt	hipt	NOUN
fnp-8974	38	37	method	method	NOUN
fnp-8974	38	38	performed	perform	VERB
fnp-8974	38	39	consistently	consistently	ADV
fnp-8974	38	40	better	well	ADV
fnp-8974	38	41	in	in	ADP
fnp-8974	38	42	predicting	predict	VERB
fnp-8974	38	43	the	the	DET
fnp-8974	38	44	molecular	molecular	ADJ
fnp-8974	38	45	epn	epn	NOUN
fnp-8974	38	46	types	type	NOUN
fnp-8974	38	47	from	from	ADP
fnp-8974	38	48	the	the	DET
fnp-8974	38	49	image	image	NOUN
fnp-8974	38	50	data	datum	NOUN
fnp-8974	38	51	.	.	PUNCT
fnp-8974	39	1	conclusion(s	conclusion(s	NOUN
fnp-8974	39	2	):	):	PUNCT
fnp-8974	39	3	this	this	DET
fnp-8974	39	4	study	study	NOUN
fnp-8974	39	5	aims	aim	VERB
fnp-8974	39	6	to	to	PART
fnp-8974	39	7	leverage	leverage	VERB
fnp-8974	39	8	the	the	DET
fnp-8974	39	9	prospects	prospect	NOUN
fnp-8974	39	10	of	of	ADP
fnp-8974	39	11	computational	computational	ADJ
fnp-8974	39	12	pathology	pathology	NOUN
fnp-8974	39	13	for	for	ADP
fnp-8974	39	14	cns	cns	PROPN
fnp-8974	39	15	tumour	tumour	NOUN
fnp-8974	39	16	diagnostics	diagnostic	NOUN
fnp-8974	39	17	,	,	PUNCT
fnp-8974	39	18	driven	drive	VERB
fnp-8974	39	19	by	by	ADP
fnp-8974	39	20	the	the	DET
fnp-8974	39	21	increasing	increase	VERB
fnp-8974	39	22	digitization	digitization	NOUN
fnp-8974	39	23	of	of	ADP
fnp-8974	39	24	pathology	pathology	NOUN
fnp-8974	39	25	workflows	workflow	NOUN
fnp-8974	39	26	.	.	PUNCT
fnp-8974	40	1	selecting	select	VERB
fnp-8974	40	2	the	the	DET
fnp-8974	40	3	clinically	clinically	ADV
fnp-8974	40	4	relevant	relevant	ADJ
fnp-8974	40	5	epns	epns	NOUN
fnp-8974	40	6	as	as	ADP
fnp-8974	40	7	use	use	NOUN
fnp-8974	40	8	case	case	NOUN
fnp-8974	40	9	,	,	PUNCT
fnp-8974	40	10	we	we	PRON
fnp-8974	40	11	demonstrate	demonstrate	VERB
fnp-8974	40	12	accurate	accurate	ADJ
fnp-8974	40	13	predictions	prediction	NOUN
fnp-8974	40	14	of	of	ADP
fnp-8974	40	15	molecular	molecular	ADJ
fnp-8974	40	16	epn	epn	NOUN
fnp-8974	40	17	types	type	NOUN
fnp-8974	40	18	based	base	VERB
fnp-8974	40	19	on	on	ADP
fnp-8974	40	20	inexpensive	inexpensive	ADJ
fnp-8974	40	21	,	,	PUNCT
fnp-8974	40	22	fast	fast	ADV
fnp-8974	40	23	to	to	PART
fnp-8974	40	24	acquire	acquire	VERB
fnp-8974	40	25	image	image	NOUN
fnp-8974	40	26	data	datum	NOUN
fnp-8974	40	27	.	.	PUNCT
fnp-8974	41	1	p02	p02	X
fnp-8974	41	2	free	free	ADJ
fnp-8974	41	3	neuropathol	neuropathol	NOUN
fnp-8974	41	4	6:17:8	6:17:8	NUM
fnp-8974	41	5	three	three	NUM
fnp-8974	41	6	dimensional	dimensional	ADJ
fnp-8974	41	7	reconstruction	reconstruction	NOUN
fnp-8974	41	8	of	of	ADP
fnp-8974	41	9	neurons	neuron	NOUN
fnp-8974	41	10	and	and	CCONJ
fnp-8974	41	11	connectivity	connectivity	NOUN
fnp-8974	41	12	patterns	pattern	NOUN
fnp-8974	41	13	in	in	ADP
fnp-8974	41	14	the	the	DET
fnp-8974	41	15	human	human	ADJ
fnp-8974	41	16	spinal	spinal	NOUN
fnp-8974	41	17	cord	cord	NOUN
fnp-8974	41	18	anika	anika	PROPN
fnp-8974	41	19	simonovska	simonovska	PROPN
fnp-8974	41	20	serra1	serra1	PROPN
fnp-8974	41	21	,	,	PUNCT
fnp-8974	41	22	philipp	philipp	PROPN
fnp-8974	41	23	jauk2	jauk2	PROPN
fnp-8974	41	24	,	,	PUNCT
fnp-8974	41	25	sonja	sonja	PROPN
fnp-8974	41	26	klement2	klement2	PROPN
fnp-8974	41	27	,	,	PUNCT
fnp-8974	41	28	andreas	andreas	PROPN
fnp-8974	41	29	hainfellner3	hainfellner3	PROPN
fnp-8974	41	30	,	,	PUNCT
fnp-8974	41	31	romana	romana	PROPN
fnp-8974	41	32	höftberger1	höftberger1	PROPN
fnp-8974	41	33	,	,	PUNCT
fnp-8974	41	34	karen	karen	PROPN
fnp-8974	41	35	minassian2	minassian2	PROPN
fnp-8974	41	36	1	1	NUM
fnp-8974	41	37	medical	medical	ADJ
fnp-8974	41	38	university	university	PROPN
fnp-8974	41	39	of	of	ADP
fnp-8974	41	40	vienna	vienna	PROPN
fnp-8974	41	41	,	,	PUNCT
fnp-8974	41	42	division	division	NOUN
fnp-8974	41	43	of	of	ADP
fnp-8974	41	44	neuropathology	neuropathology	NOUN
fnp-8974	41	45	and	and	CCONJ
fnp-8974	41	46	neurochemistry	neurochemistry	NOUN
fnp-8974	41	47	,	,	PUNCT
fnp-8974	41	48	department	department	NOUN
fnp-8974	41	49	of	of	ADP
fnp-8974	41	50	neurology	neurology	NOUN
fnp-8974	41	51	,	,	PUNCT
fnp-8974	41	52	vienna	vienna	PROPN
fnp-8974	41	53	,	,	PUNCT
fnp-8974	41	54	austria	austria	PROPN
fnp-8974	41	55	2	2	NUM
fnp-8974	41	56	medical	medical	ADJ
fnp-8974	41	57	university	university	PROPN
fnp-8974	41	58	of	of	ADP
fnp-8974	41	59	vienna	vienna	PROPN
fnp-8974	41	60	,	,	PUNCT
fnp-8974	41	61	center	center	NOUN
fnp-8974	41	62	for	for	ADP
fnp-8974	41	63	medical	medical	ADJ
fnp-8974	41	64	physics	physics	NOUN
fnp-8974	41	65	and	and	CCONJ
fnp-8974	41	66	biomedical	biomedical	ADJ
fnp-8974	41	67	engineering	engineering	NOUN
fnp-8974	41	68	,	,	PUNCT
fnp-8974	41	69	vienna	vienna	PROPN
fnp-8974	41	70	,	,	PUNCT
fnp-8974	41	71	austria	austria	PROPN
fnp-8974	41	72	3	3	NUM
fnp-8974	41	73	medical	medical	ADJ
fnp-8974	41	74	university	university	PROPN
fnp-8974	41	75	of	of	ADP
fnp-8974	41	76	vienna	vienna	PROPN
fnp-8974	41	77	,	,	PUNCT
fnp-8974	41	78	center	center	NOUN
fnp-8974	41	79	for	for	ADP
fnp-8974	41	80	anatomy	anatomy	NOUN
fnp-8974	41	81	and	and	CCONJ
fnp-8974	41	82	cell	cell	NOUN
fnp-8974	41	83	biology	biology	NOUN
fnp-8974	41	84	,	,	PUNCT
fnp-8974	41	85	vienna	vienna	PROPN
fnp-8974	41	86	,	,	PUNCT
fnp-8974	41	87	austria	austria	PROPN
fnp-8974	41	88	background	background	NOUN
fnp-8974	41	89	:	:	PUNCT
fnp-8974	41	90	traditional	traditional	ADJ
fnp-8974	41	91	histopathological	histopathological	ADJ
fnp-8974	41	92	staining	stain	VERB
fnp-8974	41	93	methods	method	NOUN
fnp-8974	41	94	are	be	AUX
fnp-8974	41	95	performed	perform	VERB
fnp-8974	41	96	on	on	ADP
fnp-8974	41	97	specimens	specimen	NOUN
fnp-8974	41	98	with	with	ADP
fnp-8974	41	99	a	a	DET
fnp-8974	41	100	thickness	thickness	NOUN
fnp-8974	41	101	of	of	ADP
fnp-8974	41	102	2–5	2–5	PROPN
fnp-8974	41	103	 	 	SPACE
fnp-8974	41	104	μm	μm	NUM
fnp-8974	41	105	,	,	PUNCT
fnp-8974	41	106	providing	provide	VERB
fnp-8974	41	107	a	a	DET
fnp-8974	41	108	two	two	NUM
fnp-8974	41	109	-	-	PUNCT
fnp-8974	41	110	dimensional	dimensional	ADJ
fnp-8974	41	111	cross	cross	ADJ
fnp-8974	41	112	-	-	ADJ
fnp-8974	41	113	sectional	sectional	ADJ
fnp-8974	41	114	view	view	NOUN
fnp-8974	41	115	of	of	ADP
fnp-8974	41	116	neurons	neuron	NOUN
fnp-8974	41	117	that	that	PRON
fnp-8974	41	118	is	be	AUX
fnp-8974	41	119	largely	largely	ADV
fnp-8974	41	120	limited	limit	VERB
fnp-8974	41	121	to	to	ADP
fnp-8974	41	122	the	the	DET
fnp-8974	41	123	soma	soma	NOUN
fnp-8974	41	124	and	and	CCONJ
fnp-8974	41	125	proximal	proximal	ADJ
fnp-8974	41	126	dendrites	dendrite	NOUN
fnp-8974	41	127	.	.	PUNCT
fnp-8974	42	1	a	a	DET
fnp-8974	42	2	staining	stain	VERB
fnp-8974	42	3	method	method	NOUN
fnp-8974	42	4	that	that	PRON
fnp-8974	42	5	enables	enable	VERB
fnp-8974	42	6	a	a	DET
fnp-8974	42	7	three	three	NUM
fnp-8974	42	8	-	-	PUNCT
fnp-8974	42	9	dimensional	dimensional	ADJ
fnp-8974	42	10	visualization	visualization	NOUN
fnp-8974	42	11	of	of	ADP
fnp-8974	42	12	whole	whole	ADJ
fnp-8974	42	13	neurons	neuron	NOUN
fnp-8974	42	14	is	be	AUX
fnp-8974	42	15	the	the	DET
fnp-8974	42	16	golgi	golgi	NOUN
fnp-8974	42	17	-	-	PUNCT
fnp-8974	42	18	cox	cox	PROPN
fnp-8974	42	19	impregnation	impregnation	NOUN
fnp-8974	42	20	technique	technique	NOUN
fnp-8974	42	21	,	,	PUNCT
fnp-8974	42	22	which	which	PRON
fnp-8974	42	23	can	can	AUX
fnp-8974	42	24	be	be	AUX
fnp-8974	42	25	combined	combine	VERB
fnp-8974	42	26	with	with	ADP
fnp-8974	42	27	immunofluorescent	immunofluorescent	PROPN
fnp-8974	42	28	antibodies	antibody	NOUN
fnp-8974	42	29	targeting	target	VERB
fnp-8974	42	30	specific	specific	ADJ
fnp-8974	42	31	proteins	protein	NOUN
fnp-8974	42	32	.	.	PUNCT
fnp-8974	43	1	recent	recent	ADJ
fnp-8974	43	2	advancements	advancement	NOUN
fnp-8974	43	3	in	in	ADP
fnp-8974	43	4	microscopy	microscopy	NOUN
fnp-8974	43	5	imaging	imaging	NOUN
fnp-8974	43	6	and	and	CCONJ
fnp-8974	43	7	computational	computational	ADJ
fnp-8974	43	8	postprocessing	postprocessing	NOUN
fnp-8974	43	9	techniques	technique	NOUN
fnp-8974	43	10	have	have	AUX
fnp-8974	43	11	further	far	ADV
fnp-8974	43	12	facilitated	facilitate	VERB
fnp-8974	43	13	the	the	DET
fnp-8974	43	14	acquisition	acquisition	NOUN
fnp-8974	43	15	of	of	ADP
fnp-8974	43	16	high	high	ADJ
fnp-8974	43	17	-	-	PUNCT
fnp-8974	43	18	resolution	resolution	NOUN
fnp-8974	43	19	images	image	NOUN
fnp-8974	43	20	of	of	ADP
fnp-8974	43	21	neurons	neuron	NOUN
fnp-8974	43	22	.	.	PUNCT
fnp-8974	44	1	objective(s	objective(s	NOUN
fnp-8974	44	2	):	):	PUNCT
fnp-8974	44	3	to	to	PART
fnp-8974	44	4	provide	provide	VERB
fnp-8974	44	5	a	a	DET
fnp-8974	44	6	three	three	NUM
fnp-8974	44	7	-	-	PUNCT
fnp-8974	44	8	dimensional	dimensional	ADJ
fnp-8974	44	9	visualization	visualization	NOUN
fnp-8974	44	10	of	of	ADP
fnp-8974	44	11	single	single	ADJ
fnp-8974	44	12	neurons	neuron	NOUN
fnp-8974	44	13	in	in	ADP
fnp-8974	44	14	the	the	DET
fnp-8974	44	15	spinal	spinal	ADJ
fnp-8974	44	16	cord	cord	NOUN
fnp-8974	44	17	and	and	CCONJ
fnp-8974	44	18	their	their	PRON
fnp-8974	44	19	connectivity	connectivity	NOUN
fnp-8974	44	20	patterns	pattern	NOUN
fnp-8974	44	21	,	,	PUNCT
fnp-8974	44	22	as	as	ADV
fnp-8974	44	23	well	well	ADV
fnp-8974	44	24	as	as	ADP
fnp-8974	44	25	the	the	DET
fnp-8974	44	26	dendritic	dendritic	ADJ
fnp-8974	44	27	spine	spine	ADJ
fnp-8974	44	28	morphology	morphology	NOUN
fnp-8974	44	29	and	and	CCONJ
fnp-8974	44	30	density	density	NOUN
fnp-8974	44	31	that	that	PRON
fnp-8974	44	32	are	be	AUX
fnp-8974	44	33	crucial	crucial	ADJ
fnp-8974	44	34	for	for	ADP
fnp-8974	44	35	synaptic	synaptic	ADJ
fnp-8974	44	36	plasticity	plasticity	NOUN
fnp-8974	44	37	.	.	PUNCT
fnp-8974	45	1	question(s	question(s	PROPN
fnp-8974	45	2	):	):	PUNCT
fnp-8974	45	3	to	to	PART
fnp-8974	45	4	investigate	investigate	VERB
fnp-8974	45	5	differences	difference	NOUN
fnp-8974	45	6	in	in	ADP
fnp-8974	45	7	synaptic	synaptic	ADJ
fnp-8974	45	8	density	density	NOUN
fnp-8974	45	9	in	in	ADP
fnp-8974	45	10	the	the	DET
fnp-8974	45	11	spinal	spinal	ADJ
fnp-8974	45	12	cord	cord	NOUN
fnp-8974	45	13	in	in	ADP
fnp-8974	45	14	the	the	DET
fnp-8974	45	15	context	context	NOUN
fnp-8974	45	16	of	of	ADP
fnp-8974	45	17	neurodegenerative	neurodegenerative	ADJ
fnp-8974	45	18	diseases	disease	NOUN
fnp-8974	45	19	.	.	PUNCT
fnp-8974	46	1	method(s	method(	VERB
fnp-8974	46	2	):	):	PUNCT
fnp-8974	46	3	in	in	ADP
fnp-8974	46	4	this	this	DET
fnp-8974	46	5	study	study	NOUN
fnp-8974	46	6	,	,	PUNCT
fnp-8974	46	7	human	human	ADJ
fnp-8974	46	8	post	post	ADJ
fnp-8974	46	9	-	-	ADJ
fnp-8974	46	10	mortem	mortem	ADJ
fnp-8974	46	11	spinal	spinal	ADJ
fnp-8974	46	12	cord	cord	NOUN
fnp-8974	46	13	tissue	tissue	NOUN
fnp-8974	46	14	will	will	AUX
fnp-8974	46	15	be	be	AUX
fnp-8974	46	16	used	use	VERB
fnp-8974	46	17	for	for	ADP
fnp-8974	46	18	the	the	DET
fnp-8974	46	19	golgi	golgi	NOUN
fnp-8974	46	20	-	-	PUNCT
fnp-8974	46	21	cox	cox	PROPN
fnp-8974	46	22	impregnation	impregnation	NOUN
fnp-8974	46	23	of	of	ADP
fnp-8974	46	24	spinal	spinal	ADJ
fnp-8974	46	25	neurons	neuron	NOUN
fnp-8974	46	26	in	in	ADP
fnp-8974	46	27	combination	combination	NOUN
fnp-8974	46	28	with	with	ADP
fnp-8974	46	29	tissue	tissue	NOUN
fnp-8974	46	30	clearing	clearing	NOUN
fnp-8974	46	31	and	and	CCONJ
fnp-8974	46	32	immunofluorescence	immunofluorescence	NOUN
fnp-8974	46	33	staining	staining	NOUN
fnp-8974	46	34	of	of	ADP
fnp-8974	46	35	catecholaminergic	catecholaminergic	ADJ
fnp-8974	46	36	receptors	receptor	NOUN
fnp-8974	46	37	and	and	CCONJ
fnp-8974	46	38	synaptic	synaptic	ADJ
fnp-8974	46	39	proteins	protein	NOUN
fnp-8974	46	40	.	.	PUNCT
fnp-8974	47	1	images	image	NOUN
fnp-8974	47	2	will	will	AUX
fnp-8974	47	3	be	be	AUX
fnp-8974	47	4	acquired	acquire	VERB
fnp-8974	47	5	using	use	VERB
fnp-8974	47	6	confocal	confocal	ADJ
fnp-8974	47	7	microscopy	microscopy	NOUN
fnp-8974	47	8	.	.	PUNCT
fnp-8974	48	1	result(s	result(s	NOUN
fnp-8974	48	2	):	):	PUNCT
fnp-8974	48	3	single	single	ADJ
fnp-8974	48	4	-	-	PUNCT
fnp-8974	48	5	impregnated	impregnate	VERB
fnp-8974	48	6	neurons	neuron	NOUN
fnp-8974	48	7	including	include	VERB
fnp-8974	48	8	their	their	PRON
fnp-8974	48	9	soma	soma	NOUN
fnp-8974	48	10	and	and	CCONJ
fnp-8974	48	11	dendritic	dendritic	ADJ
fnp-8974	48	12	architecture	architecture	NOUN
fnp-8974	48	13	will	will	AUX
fnp-8974	48	14	be	be	AUX
fnp-8974	48	15	segmented	segment	VERB
fnp-8974	48	16	and	and	CCONJ
fnp-8974	48	17	subsequently	subsequently	ADV
fnp-8974	48	18	reconstructed	reconstruct	VERB
fnp-8974	48	19	in	in	ADP
fnp-8974	48	20	three	three	NUM
fnp-8974	48	21	dimensions	dimension	NOUN
fnp-8974	48	22	using	use	VERB
fnp-8974	48	23	aiand	aiand	NOUN
fnp-8974	48	24	deep	deep	ADJ
fnp-8974	48	25	learning	learning	NOUN
fnp-8974	48	26	-	-	PUNCT
fnp-8974	48	27	based	base	VERB
fnp-8974	48	28	models	model	NOUN
fnp-8974	48	29	.	.	PUNCT
fnp-8974	49	1	the	the	DET
fnp-8974	49	2	resulting	result	VERB
fnp-8974	49	3	images	image	NOUN
fnp-8974	49	4	will	will	AUX
fnp-8974	49	5	be	be	AUX
fnp-8974	49	6	compiled	compile	VERB
fnp-8974	49	7	into	into	ADP
fnp-8974	49	8	a	a	DET
fnp-8974	49	9	comprehensive	comprehensive	ADJ
fnp-8974	49	10	cytoand	cytoand	NOUN
fnp-8974	49	11	dendroarchitectonic	dendroarchitectonic	PROPN
fnp-8974	49	12	atlas	atlas	PROPN
fnp-8974	49	13	of	of	ADP
fnp-8974	49	14	the	the	DET
fnp-8974	49	15	lumbar	lumbar	NOUN
fnp-8974	49	16	spinal	spinal	NOUN
fnp-8974	49	17	cord	cord	NOUN
fnp-8974	49	18	.	.	PUNCT
fnp-8974	50	1	conclusion(s	conclusion(s	NOUN
fnp-8974	50	2	):	):	PUNCT
fnp-8974	50	3	this	this	DET
fnp-8974	50	4	staining	stain	VERB
fnp-8974	50	5	technique	technique	NOUN
fnp-8974	50	6	can	can	AUX
fnp-8974	50	7	be	be	AUX
fnp-8974	50	8	applied	apply	VERB
fnp-8974	50	9	to	to	ADP
fnp-8974	50	10	various	various	ADJ
fnp-8974	50	11	regions	region	NOUN
fnp-8974	50	12	of	of	ADP
fnp-8974	50	13	cns	cns	NOUN
fnp-8974	50	14	and	and	CCONJ
fnp-8974	50	15	offers	offer	VERB
fnp-8974	50	16	numerous	numerous	ADJ
fnp-8974	50	17	applications	application	NOUN
fnp-8974	50	18	in	in	ADP
fnp-8974	50	19	basic	basic	ADJ
fnp-8974	50	20	research	research	NOUN
fnp-8974	50	21	,	,	PUNCT
fnp-8974	50	22	providing	provide	VERB
fnp-8974	50	23	a	a	DET
fnp-8974	50	24	deeper	deep	ADJ
fnp-8974	50	25	understanding	understanding	NOUN
fnp-8974	50	26	of	of	ADP
fnp-8974	50	27	healthy	healthy	ADJ
fnp-8974	50	28	neuronal	neuronal	ADJ
fnp-8974	50	29	function	function	NOUN
fnp-8974	50	30	and	and	CCONJ
fnp-8974	50	31	potentially	potentially	ADV
fnp-8974	50	32	offering	offer	VERB
fnp-8974	50	33	new	new	ADJ
fnp-8974	50	34	insights	insight	NOUN
fnp-8974	50	35	into	into	ADP
fnp-8974	50	36	neurological	neurological	ADJ
fnp-8974	50	37	disorders	disorder	NOUN
fnp-8974	50	38	associated	associate	VERB
fnp-8974	50	39	with	with	ADP
fnp-8974	50	40	neurodegeneration	neurodegeneration	NOUN
fnp-8974	50	41	and	and	CCONJ
fnp-8974	50	42	synaptopathy	synaptopathy	NOUN
fnp-8974	50	43	.	.	PUNCT
fnp-8974	51	1	ii	ii	PROPN
fnp-8974	51	2	.	.	PUNCT
fnp-8974	52	1	digital	digital	PROPN
fnp-8974	52	2	pathology	pathology	PROPN
fnp-8974	52	3	p03	p03	PROPN
fnp-8974	52	4	free	free	PROPN
fnp-8974	52	5	neuropathol	neuropathol	NOUN
fnp-8974	52	6	6:17:9	6:17:9	NUM
fnp-8974	52	7	reliable	reliable	ADJ
fnp-8974	52	8	and	and	CCONJ
fnp-8974	52	9	instant	instant	ADJ
fnp-8974	52	10	slice	slice	NOUN
fnp-8974	52	11	-	-	PUNCT
fnp-8974	52	12	free	free	ADJ
fnp-8974	52	13	intraoperative	intraoperative	ADJ
fnp-8974	52	14	histology	histology	NOUN
fnp-8974	52	15	in	in	ADP
fnp-8974	52	16	neurooncology	neurooncology	NOUN
fnp-8974	52	17	:	:	PUNCT
fnp-8974	52	18	updated	update	VERB
fnp-8974	52	19	study	study	NOUN
fnp-8974	52	20	results	result	VERB
fnp-8974	52	21	with	with	ADP
fnp-8974	52	22	multiphoton	multiphoton	NOUN
fnp-8974	52	23	microscopy	microscopy	PROPN
fnp-8974	52	24	jessica	jessica	PROPN
fnp-8974	52	25	kren1	kren1	PROPN
fnp-8974	52	26	,	,	PUNCT
fnp-8974	52	27	jan	jan	PROPN
fnp-8974	52	28	philip	philip	PROPN
fnp-8974	52	29	kolb2	kolb2	PROPN
fnp-8974	52	30	,	,	PUNCT
fnp-8974	52	31	matthias	matthias	PROPN
fnp-8974	52	32	strauch2	strauch2	PROPN
fnp-8974	52	33	,	,	PUNCT
fnp-8974	52	34	niloofar	niloofar	ADJ
fnp-8974	52	35	khosravi2	khosravi2	PROPN
fnp-8974	52	36	,	,	PUNCT
fnp-8974	52	37	álvaro	álvaro	PROPN
fnp-8974	52	38	vega	vega	PROPN
fnp-8974	52	39	pérez2	pérez2	PROPN
fnp-8974	52	40	,	,	PUNCT
fnp-8974	52	41	matteo	matteo	PROPN
fnp-8974	52	42	m.	m.	PROPN
fnp-8974	52	43	bonsanto1	bonsanto1	PROPN
fnp-8974	52	44	,	,	PUNCT
fnp-8974	52	45	julia	julia	PROPN
fnp-8974	52	46	e.	e.	PROPN
fnp-8974	52	47	neumann3,4	neumann3,4	PROPN
fnp-8974	52	48	1	1	NUM
fnp-8974	52	49	uksh	uksh	NOUN
fnp-8974	52	50	lübeck	lübeck	PROPN
fnp-8974	52	51	,	,	PUNCT
fnp-8974	52	52	klinik	klinik	PROPN
fnp-8974	52	53	für	für	PROPN
fnp-8974	52	54	neurochirurgie	neurochirurgie	PROPN
fnp-8974	52	55	,	,	PUNCT
fnp-8974	52	56	lübeck	lübeck	PROPN
fnp-8974	52	57	,	,	PUNCT
fnp-8974	52	58	germany	germany	PROPN
fnp-8974	52	59	2	2	NUM
fnp-8974	52	60	histolution	histolution	NOUN
fnp-8974	52	61	gmbh	gmbh	NOUN
fnp-8974	52	62	,	,	PUNCT
fnp-8974	52	63	lübeck	lübeck	PROPN
fnp-8974	52	64	,	,	PUNCT
fnp-8974	52	65	germany	germany	PROPN
fnp-8974	52	66	3	3	NUM
fnp-8974	52	67	uke	uke	PROPN
fnp-8974	52	68	hamburg	hamburg	PROPN
fnp-8974	52	69	,	,	PUNCT
fnp-8974	52	70	institut	institut	PROPN
fnp-8974	52	71	für	für	PROPN
fnp-8974	52	72	neuropathologie	neuropathologie	PROPN
fnp-8974	52	73	,	,	PUNCT
fnp-8974	52	74	hamburg	hamburg	PROPN
fnp-8974	52	75	,	,	PUNCT
fnp-8974	52	76	germany	germany	PROPN
fnp-8974	52	77	4	4	NUM
fnp-8974	52	78	uke	uke	PROPN
fnp-8974	52	79	hamburg	hamburg	PROPN
fnp-8974	52	80	,	,	PUNCT
fnp-8974	52	81	zentrum	zentrum	PROPN
fnp-8974	52	82	für	für	PROPN
fnp-8974	52	83	molekulare	molekulare	PROPN
fnp-8974	52	84	neurobiologie	neurobiologie	PROPN
fnp-8974	52	85	hamburg	hamburg	PROPN
fnp-8974	52	86	(	(	PUNCT
fnp-8974	52	87	zmnh	zmnh	PROPN
fnp-8974	52	88	)	)	PUNCT
fnp-8974	52	89	,	,	PUNCT
fnp-8974	52	90	hamburg	hamburg	PROPN
fnp-8974	52	91	,	,	PUNCT
fnp-8974	52	92	germany	germany	PROPN
fnp-8974	52	93	multiphoton	multiphoton	PROPN
fnp-8974	52	94	microscopy	microscopy	PROPN
fnp-8974	52	95	(	(	PUNCT
fnp-8974	52	96	mpm	mpm	NOUN
fnp-8974	52	97	)	)	PUNCT
fnp-8974	52	98	enables	enable	VERB
fnp-8974	52	99	rapid	rapid	ADJ
fnp-8974	52	100	,	,	PUNCT
fnp-8974	52	101	high	high	ADJ
fnp-8974	52	102	-	-	PUNCT
fnp-8974	52	103	quality	quality	NOUN
fnp-8974	52	104	histological	histological	ADJ
fnp-8974	52	105	assessment	assessment	NOUN
fnp-8974	52	106	of	of	ADP
fnp-8974	52	107	tissue	tissue	NOUN
fnp-8974	52	108	samples	sample	NOUN
fnp-8974	52	109	without	without	ADP
fnp-8974	52	110	the	the	DET
fnp-8974	52	111	need	need	NOUN
fnp-8974	52	112	for	for	ADP
fnp-8974	52	113	paraffin	paraffin	NOUN
fnp-8974	52	114	or	or	CCONJ
fnp-8974	52	115	frozen	frozen	ADJ
fnp-8974	52	116	sectioning	sectioning	NOUN
fnp-8974	52	117	.	.	PUNCT
fnp-8974	53	1	this	this	DET
fnp-8974	53	2	technology	technology	NOUN
fnp-8974	53	3	can	can	AUX
fnp-8974	53	4	be	be	AUX
fnp-8974	53	5	integrated	integrate	VERB
fnp-8974	53	6	into	into	ADP
fnp-8974	53	7	the	the	DET
fnp-8974	53	8	operating	operating	NOUN
fnp-8974	53	9	room	room	NOUN
fnp-8974	53	10	workflow	workflow	NOUN
fnp-8974	53	11	,	,	PUNCT
fnp-8974	53	12	providing	provide	VERB
fnp-8974	53	13	results	result	NOUN
fnp-8974	53	14	within	within	ADP
fnp-8974	53	15	few	few	ADJ
fnp-8974	53	16	minutes	minute	NOUN
fnp-8974	53	17	.	.	PUNCT
fnp-8974	54	1	the	the	DET
fnp-8974	54	2	aim	aim	NOUN
fnp-8974	54	3	of	of	ADP
fnp-8974	54	4	this	this	DET
fnp-8974	54	5	study	study	NOUN
fnp-8974	54	6	was	be	AUX
fnp-8974	54	7	to	to	PART
fnp-8974	54	8	evaluate	evaluate	VERB
fnp-8974	54	9	the	the	DET
fnp-8974	54	10	diagnostic	diagnostic	ADJ
fnp-8974	54	11	accuracy	accuracy	NOUN
fnp-8974	54	12	and	and	CCONJ
fnp-8974	54	13	practical	practical	ADJ
fnp-8974	54	14	applicability	applicability	NOUN
fnp-8974	54	15	of	of	ADP
fnp-8974	54	16	mpm	mpm	NOUN
fnp-8974	54	17	for	for	ADP
fnp-8974	54	18	intraoperative	intraoperative	ADJ
fnp-8974	54	19	assessment	assessment	NOUN
fnp-8974	54	20	of	of	ADP
fnp-8974	54	21	neurosurgical	neurosurgical	ADJ
fnp-8974	54	22	tumor	tumor	NOUN
fnp-8974	54	23	samples	sample	NOUN
fnp-8974	54	24	.	.	PUNCT
fnp-8974	55	1	the	the	DET
fnp-8974	55	2	central	central	ADJ
fnp-8974	55	3	question	question	NOUN
fnp-8974	55	4	was	be	AUX
fnp-8974	55	5	whether	whether	SCONJ
fnp-8974	55	6	mpm	mpm	NOUN
fnp-8974	55	7	can	can	AUX
fnp-8974	55	8	reliably	reliably	ADV
fnp-8974	55	9	reproduce	reproduce	VERB
fnp-8974	55	10	routine	routine	ADJ
fnp-8974	55	11	histological	histological	ADJ
fnp-8974	55	12	diagnoses	diagnosis	NOUN
fnp-8974	55	13	and	and	CCONJ
fnp-8974	55	14	thus	thus	ADV
fnp-8974	55	15	support	support	VERB
fnp-8974	55	16	fast	fast	ADJ
fnp-8974	55	17	intraoperative	intraoperative	ADJ
fnp-8974	55	18	decision	decision	NOUN
fnp-8974	55	19	-	-	PUNCT
fnp-8974	55	20	making	making	NOUN
fnp-8974	55	21	in	in	ADP
fnp-8974	55	22	neurosurgery	neurosurgery	NOUN
fnp-8974	55	23	.	.	PUNCT
fnp-8974	56	1	a	a	DET
fnp-8974	56	2	total	total	NOUN
fnp-8974	56	3	of	of	ADP
fnp-8974	56	4	76	76	NUM
fnp-8974	56	5	neurosurgical	neurosurgical	ADJ
fnp-8974	56	6	tumor	tumor	NOUN
fnp-8974	56	7	samples	sample	NOUN
fnp-8974	56	8	were	be	AUX
fnp-8974	56	9	examined	examine	VERB
fnp-8974	56	10	using	use	VERB
fnp-8974	56	11	mpm	mpm	NOUN
fnp-8974	56	12	and	and	CCONJ
fnp-8974	56	13	compared	compare	VERB
fnp-8974	56	14	to	to	ADP
fnp-8974	56	15	standard	standard	ADJ
fnp-8974	56	16	paraffin	paraffin	NOUN
fnp-8974	56	17	section	section	NOUN
fnp-8974	56	18	histology	histology	NOUN
fnp-8974	56	19	.	.	PUNCT
fnp-8974	57	1	after	after	ADP
fnp-8974	57	2	a	a	DET
fnp-8974	57	3	brief	brief	ADJ
fnp-8974	57	4	2.5	2.5	NUM
fnp-8974	57	5	-	-	PUNCT
fnp-8974	57	6	minute	minute	NOUN
fnp-8974	57	7	staining	staining	NOUN
fnp-8974	57	8	,	,	PUNCT
fnp-8974	57	9	tissue	tissue	NOUN
fnp-8974	57	10	blocks	block	NOUN
fnp-8974	57	11	were	be	AUX
fnp-8974	57	12	scanned	scan	VERB
fnp-8974	57	13	at	at	ADP
fnp-8974	57	14	4	4	NUM
fnp-8974	57	15	 	 	SPACE
fnp-8974	57	16	min	min	PROPN
fnp-8974	57	17	/	/	SYM
fnp-8974	57	18	cm²	cm²	PROPN
fnp-8974	57	19	,	,	PUNCT
fnp-8974	57	20	with	with	ADP
fnp-8974	57	21	potential	potential	ADJ
fnp-8974	57	22	acceleration	acceleration	NOUN
fnp-8974	57	23	to	to	ADP
fnp-8974	57	24	30	30	NUM
fnp-8974	57	25	 	 	SPACE
fnp-8974	57	26	s	s	PROPN
fnp-8974	57	27	/	/	SYM
fnp-8974	57	28	cm²	cm²	PROPN
fnp-8974	57	29	.	.	PUNCT
fnp-8974	58	1	the	the	DET
fnp-8974	58	2	resulting	result	VERB
fnp-8974	58	3	digital	digital	ADJ
fnp-8974	58	4	images	image	NOUN
fnp-8974	58	5	were	be	AUX
fnp-8974	58	6	assessed	assess	VERB
fnp-8974	58	7	in	in	ADP
fnp-8974	58	8	a	a	DET
fnp-8974	58	9	blinded	blind	VERB
fnp-8974	58	10	manner	manner	NOUN
fnp-8974	58	11	by	by	ADP
fnp-8974	58	12	a	a	DET
fnp-8974	58	13	board	board	NOUN
fnp-8974	58	14	-	-	PUNCT
fnp-8974	58	15	certified	certify	VERB
fnp-8974	58	16	neuropathologist	neuropathologist	NOUN
fnp-8974	58	17	with	with	ADP
fnp-8974	58	18	no	no	DET
fnp-8974	58	19	prior	prior	ADJ
fnp-8974	58	20	mpm	mpm	NOUN
fnp-8974	58	21	experience	experience	NOUN
fnp-8974	58	22	.	.	PUNCT
fnp-8974	59	1	for	for	ADP
fnp-8974	59	2	43	43	NUM
fnp-8974	59	3	of	of	ADP
fnp-8974	59	4	the	the	DET
fnp-8974	59	5	76	76	NUM
fnp-8974	59	6	samples	sample	NOUN
fnp-8974	59	7	,	,	PUNCT
fnp-8974	59	8	the	the	DET
fnp-8974	59	9	neuropathologist	neuropathologist	NOUN
fnp-8974	59	10	also	also	ADV
fnp-8974	59	11	received	receive	VERB
fnp-8974	59	12	the	the	DET
fnp-8974	59	13	suspected	suspect	VERB
fnp-8974	59	14	clinical	clinical	ADJ
fnp-8974	59	15	diagnosis	diagnosis	NOUN
fnp-8974	59	16	in	in	ADP
fnp-8974	59	17	addition	addition	NOUN
fnp-8974	59	18	to	to	ADP
fnp-8974	59	19	age	age	NOUN
fnp-8974	59	20	,	,	PUNCT
fnp-8974	59	21	sex	sex	NOUN
fnp-8974	59	22	,	,	PUNCT
fnp-8974	59	23	and	and	CCONJ
fnp-8974	59	24	localization	localization	NOUN
fnp-8974	59	25	.	.	PUNCT
fnp-8974	60	1	in	in	ADP
fnp-8974	60	2	72	72	NUM
fnp-8974	60	3	of	of	ADP
fnp-8974	60	4	76	76	NUM
fnp-8974	60	5	cases	case	NOUN
fnp-8974	60	6	(	(	PUNCT
fnp-8974	60	7	94.7	94.7	NUM
fnp-8974	60	8	 	 	SPACE
fnp-8974	60	9	%	%	NOUN
fnp-8974	60	10	)	)	PUNCT
fnp-8974	60	11	,	,	PUNCT
fnp-8974	60	12	mpm	mpm	NOUN
fnp-8974	60	13	results	result	NOUN
fnp-8974	60	14	were	be	AUX
fnp-8974	60	15	fully	fully	ADV
fnp-8974	60	16	consistent	consistent	ADJ
fnp-8974	60	17	with	with	ADP
fnp-8974	60	18	routine	routine	ADJ
fnp-8974	60	19	histology	histology	NOUN
fnp-8974	60	20	.	.	PUNCT
fnp-8974	61	1	notably	notably	ADV
fnp-8974	61	2	,	,	PUNCT
fnp-8974	61	3	in	in	ADP
fnp-8974	61	4	all	all	DET
fnp-8974	61	5	43	43	NUM
fnp-8974	61	6	cases	case	NOUN
fnp-8974	61	7	where	where	SCONJ
fnp-8974	61	8	the	the	DET
fnp-8974	61	9	suspected	suspect	VERB
fnp-8974	61	10	diagnosis	diagnosis	NOUN
fnp-8974	61	11	was	be	AUX
fnp-8974	61	12	provided	provide	VERB
fnp-8974	61	13	,	,	PUNCT
fnp-8974	61	14	mpm	mpm	NOUN
fnp-8974	61	15	findings	finding	NOUN
fnp-8974	61	16	matched	match	VERB
fnp-8974	61	17	the	the	DET
fnp-8974	61	18	final	final	ADJ
fnp-8974	61	19	diagnosis	diagnosis	NOUN
fnp-8974	61	20	.	.	PUNCT
fnp-8974	62	1	the	the	DET
fnp-8974	62	2	digital	digital	ADJ
fnp-8974	62	3	images	image	NOUN
fnp-8974	62	4	showed	show	VERB
fnp-8974	62	5	excellent	excellent	ADJ
fnp-8974	62	6	visualization	visualization	NOUN
fnp-8974	62	7	of	of	ADP
fnp-8974	62	8	cell	cell	NOUN
fnp-8974	62	9	morphology	morphology	NOUN
fnp-8974	62	10	and	and	CCONJ
fnp-8974	62	11	tissue	tissue	NOUN
fnp-8974	62	12	architecture	architecture	NOUN
fnp-8974	62	13	,	,	PUNCT
fnp-8974	62	14	closely	closely	ADV
fnp-8974	62	15	resembling	resemble	VERB
fnp-8974	62	16	standard	standard	ADJ
fnp-8974	62	17	h&e	h&e	PROPN
fnp-8974	62	18	slides	slide	NOUN
fnp-8974	62	19	.	.	PUNCT
fnp-8974	63	1	these	these	DET
fnp-8974	63	2	findings	finding	NOUN
fnp-8974	63	3	highlight	highlight	VERB
fnp-8974	63	4	the	the	DET
fnp-8974	63	5	reliability	reliability	NOUN
fnp-8974	63	6	of	of	ADP
fnp-8974	63	7	mpm	mpm	NOUN
fnp-8974	63	8	,	,	PUNCT
fnp-8974	63	9	even	even	ADV
fnp-8974	63	10	when	when	SCONJ
fnp-8974	63	11	used	use	VERB
fnp-8974	63	12	by	by	ADP
fnp-8974	63	13	neuropathologists	neuropathologist	NOUN
fnp-8974	63	14	without	without	ADP
fnp-8974	63	15	specific	specific	ADJ
fnp-8974	63	16	training	training	NOUN
fnp-8974	63	17	.	.	PUNCT
fnp-8974	64	1	mpm	mpm	NOUN
fnp-8974	64	2	offers	offer	VERB
fnp-8974	64	3	a	a	DET
fnp-8974	64	4	significant	significant	ADJ
fnp-8974	64	5	advance	advance	NOUN
fnp-8974	64	6	for	for	ADP
fnp-8974	64	7	intraoperative	intraoperative	ADJ
fnp-8974	64	8	diagnostics	diagnostic	NOUN
fnp-8974	64	9	,	,	PUNCT
fnp-8974	64	10	with	with	ADP
fnp-8974	64	11	the	the	DET
fnp-8974	64	12	potential	potential	NOUN
fnp-8974	64	13	to	to	PART
fnp-8974	64	14	improve	improve	VERB
fnp-8974	64	15	patient	patient	ADJ
fnp-8974	64	16	outcomes	outcome	NOUN
fnp-8974	64	17	by	by	ADP
fnp-8974	64	18	enabling	enable	VERB
fnp-8974	64	19	faster	fast	ADV
fnp-8974	64	20	and	and	CCONJ
fnp-8974	64	21	more	more	ADV
fnp-8974	64	22	accurate	accurate	ADJ
fnp-8974	64	23	decision	decision	NOUN
fnp-8974	64	24	-	-	PUNCT
fnp-8974	64	25	making	making	NOUN
fnp-8974	64	26	.	.	PUNCT
fnp-8974	65	1	ongoing	ongoing	ADJ
fnp-8974	65	2	research	research	NOUN
fnp-8974	65	3	will	will	AUX
fnp-8974	65	4	further	far	ADV
fnp-8974	65	5	optimize	optimize	VERB
fnp-8974	65	6	technical	technical	ADJ
fnp-8974	65	7	parameters	parameter	NOUN
fnp-8974	65	8	and	and	CCONJ
fnp-8974	65	9	validate	validate	VERB
fnp-8974	65	10	broad	broad	ADJ
fnp-8974	65	11	applicability	applicability	NOUN
fnp-8974	65	12	in	in	ADP
fnp-8974	65	13	neuro	neuro	NOUN
fnp-8974	65	14	-	-	PUNCT
fnp-8974	65	15	oncology	oncology	NOUN
fnp-8974	65	16	.	.	PUNCT
fnp-8974	66	1	p04	p04	PROPN
fnp-8974	66	2	free	free	ADJ
fnp-8974	66	3	neuropathol	neuropathol	NOUN
fnp-8974	66	4	6:17:10	6:17:10	NUM
fnp-8974	66	5	longitudinal	longitudinal	ADJ
fnp-8974	66	6	cell	cell	NOUN
fnp-8974	66	7	state	state	NOUN
fnp-8974	66	8	screening	screen	VERB
fnp-8974	66	9	through	through	ADP
fnp-8974	66	10	rapid	rapid	ADJ
fnp-8974	66	11	deconvolution	deconvolution	NOUN
fnp-8974	66	12	of	of	ADP
fnp-8974	66	13	intra	intra	ADJ
fnp-8974	66	14	-	-	ADJ
fnp-8974	66	15	tumor	tumor	ADJ
fnp-8974	66	16	heterogeneity	heterogeneity	NOUN
fnp-8974	66	17	in	in	ADP
fnp-8974	66	18	glioblastoma	glioblastoma	NOUN
fnp-8974	66	19	jakob	jakob	PROPN
fnp-8974	66	20	ito1,2	ito1,2	PROPN
fnp-8974	66	21	,	,	PUNCT
fnp-8974	66	22	dana	dana	PROPN
fnp-8974	66	23	silverbush3	silverbush3	PROPN
fnp-8974	66	24	,	,	PUNCT
fnp-8974	66	25	wolfgang	wolfgang	PROPN
fnp-8974	66	26	wick1,2,4	wick1,2,4	PROPN
fnp-8974	66	27	,	,	PUNCT
fnp-8974	66	28	andreas	andreas	PROPN
fnp-8974	66	29	von	von	PROPN
fnp-8974	66	30	deimling5,6	deimling5,6	PROPN
fnp-8974	66	31	,	,	PUNCT
fnp-8974	66	32	tobias	tobias	PROPN
fnp-8974	66	33	kessler1,2,4,5	kessler1,2,4,5	PROPN
fnp-8974	66	34	,	,	PUNCT
fnp-8974	66	35	felix	felix	PROPN
fnp-8974	66	36	sahm5,6	sahm5,6	PROPN
fnp-8974	66	37	,	,	PUNCT
fnp-8974	66	38	paul	paul	PROPN
fnp-8974	66	39	kerbs5,6	kerbs5,6	PROPN
fnp-8974	66	40	1	1	NUM
fnp-8974	66	41	clinical	clinical	ADJ
fnp-8974	66	42	cooperation	cooperation	NOUN
fnp-8974	66	43	unit	unit	NOUN
fnp-8974	66	44	neurooncology	neurooncology	NOUN
fnp-8974	66	45	,	,	PUNCT
fnp-8974	66	46	german	german	ADJ
fnp-8974	66	47	cancer	cancer	NOUN
fnp-8974	66	48	research	research	NOUN
fnp-8974	66	49	center	center	NOUN
fnp-8974	66	50	(	(	PUNCT
fnp-8974	66	51	dkfz	dkfz	NOUN
fnp-8974	66	52	)	)	PUNCT
fnp-8974	66	53	,	,	PUNCT
fnp-8974	66	54	german	german	ADJ
fnp-8974	66	55	cancer	cancer	NOUN
fnp-8974	66	56	consortium	consortium	NOUN
fnp-8974	66	57	(	(	PUNCT
fnp-8974	66	58	dktk	dktk	NOUN
fnp-8974	66	59	)	)	PUNCT
fnp-8974	66	60	,	,	PUNCT
fnp-8974	66	61	heidelberg	heidelberg	PROPN
fnp-8974	66	62	,	,	PUNCT
fnp-8974	66	63	germany	germany	PROPN
fnp-8974	66	64	2	2	NUM
fnp-8974	66	65	department	department	NOUN
fnp-8974	66	66	of	of	ADP
fnp-8974	66	67	neurology	neurology	NOUN
fnp-8974	66	68	,	,	PUNCT
fnp-8974	66	69	university	university	NOUN
fnp-8974	66	70	hospital	hospital	NOUN
fnp-8974	66	71	heidelberg	heidelberg	PROPN
fnp-8974	66	72	,	,	PUNCT
fnp-8974	66	73	heidelberg	heidelberg	PROPN
fnp-8974	66	74	,	,	PUNCT
fnp-8974	66	75	germany	germany	PROPN
fnp-8974	66	76	3	3	NUM
fnp-8974	66	77	department	department	PROPN
fnp-8974	66	78	of	of	ADP
fnp-8974	66	79	cancer	cancer	NOUN
fnp-8974	66	80	biology	biology	NOUN
fnp-8974	66	81	,	,	PUNCT
fnp-8974	66	82	perelman	perelman	PROPN
fnp-8974	66	83	school	school	NOUN
fnp-8974	66	84	of	of	ADP
fnp-8974	66	85	medicine	medicine	NOUN
fnp-8974	66	86	,	,	PUNCT
fnp-8974	66	87	university	university	NOUN
fnp-8974	66	88	of	of	ADP
fnp-8974	66	89	pennsylvania	pennsylvania	PROPN
fnp-8974	66	90	,	,	PUNCT
fnp-8974	66	91	philadelphia	philadelphia	PROPN
fnp-8974	66	92	,	,	PUNCT
fnp-8974	66	93	united	united	PROPN
fnp-8974	66	94	states	states	PROPN
fnp-8974	66	95	4	4	NUM
fnp-8974	66	96	national	national	ADJ
fnp-8974	66	97	center	center	NOUN
fnp-8974	66	98	for	for	ADP
fnp-8974	66	99	tumor	tumor	NOUN
fnp-8974	66	100	diseases	disease	NOUN
fnp-8974	66	101	(	(	PUNCT
fnp-8974	66	102	nct	nct	NOUN
fnp-8974	66	103	)	)	PUNCT
fnp-8974	66	104	,	,	PUNCT
fnp-8974	66	105	a	a	DET
fnp-8974	66	106	partnership	partnership	NOUN
fnp-8974	66	107	between	between	ADP
fnp-8974	66	108	dkfz	dkfz	PROPN
fnp-8974	66	109	and	and	CCONJ
fnp-8974	66	110	heidelberg	heidelberg	PROPN
fnp-8974	66	111	university	university	PROPN
fnp-8974	66	112	hospital	hospital	NOUN
fnp-8974	66	113	,	,	PUNCT
fnp-8974	66	114	heidelberg	heidelberg	PROPN
fnp-8974	66	115	,	,	PUNCT
fnp-8974	66	116	germany	germany	PROPN
fnp-8974	66	117	5	5	NUM
fnp-8974	66	118	german	german	ADJ
fnp-8974	66	119	consortium	consortium	NOUN
fnp-8974	66	120	for	for	ADP
fnp-8974	66	121	translational	translational	ADJ
fnp-8974	66	122	cancer	cancer	NOUN
fnp-8974	66	123	research	research	NOUN
fnp-8974	66	124	(	(	PUNCT
fnp-8974	66	125	dktk	dktk	NOUN
fnp-8974	66	126	)	)	PUNCT
fnp-8974	66	127	,	,	PUNCT
fnp-8974	66	128	german	german	ADJ
fnp-8974	66	129	cancer	cancer	NOUN
fnp-8974	66	130	research	research	NOUN
fnp-8974	66	131	center	center	NOUN
fnp-8974	66	132	(	(	PUNCT
fnp-8974	66	133	dkfz	dkfz	PROPN
fnp-8974	66	134	)	)	PUNCT
fnp-8974	66	135	,	,	PUNCT
fnp-8974	66	136	heidelberg	heidelberg	PROPN
fnp-8974	66	137	,	,	PUNCT
fnp-8974	66	138	germany	germany	PROPN
fnp-8974	66	139	6	6	NUM
fnp-8974	66	140	department	department	NOUN
fnp-8974	66	141	of	of	ADP
fnp-8974	66	142	neuropathology	neuropathology	NOUN
fnp-8974	66	143	,	,	PUNCT
fnp-8974	66	144	university	university	NOUN
fnp-8974	66	145	hospital	hospital	NOUN
fnp-8974	66	146	heidelberg	heidelberg	PROPN
fnp-8974	66	147	,	,	PUNCT
fnp-8974	66	148	heidelberg	heidelberg	PROPN
fnp-8974	66	149	,	,	PUNCT
fnp-8974	66	150	germany	germany	PROPN
fnp-8974	66	151	background	background	NOUN
fnp-8974	66	152	:	:	PUNCT
fnp-8974	66	153	glioblastoma	glioblastoma	NOUN
fnp-8974	66	154	(	(	PUNCT
fnp-8974	66	155	gb	gb	NOUN
fnp-8974	66	156	)	)	PUNCT
fnp-8974	66	157	is	be	AUX
fnp-8974	66	158	characterized	characterize	VERB
fnp-8974	66	159	by	by	ADP
fnp-8974	66	160	intra	intra	ADJ
fnp-8974	66	161	-	-	ADJ
fnp-8974	66	162	tumor	tumor	ADJ
fnp-8974	66	163	heterogeneity	heterogeneity	NOUN
fnp-8974	66	164	(	(	PUNCT
fnp-8974	66	165	ith	ith	PROPN
fnp-8974	66	166	)	)	PUNCT
fnp-8974	66	167	,	,	PUNCT
fnp-8974	66	168	a	a	DET
fnp-8974	66	169	major	major	ADJ
fnp-8974	66	170	factor	factor	NOUN
fnp-8974	66	171	contributing	contribute	VERB
fnp-8974	66	172	to	to	ADP
fnp-8974	66	173	tumor	tumor	NOUN
fnp-8974	66	174	progression	progression	NOUN
fnp-8974	66	175	and	and	CCONJ
fnp-8974	66	176	therapy	therapy	NOUN
fnp-8974	66	177	resistance	resistance	NOUN
fnp-8974	66	178	.	.	PUNCT
fnp-8974	67	1	the	the	DET
fnp-8974	67	2	limited	limited	ADJ
fnp-8974	67	3	efficacy	efficacy	NOUN
fnp-8974	67	4	of	of	ADP
fnp-8974	67	5	precision	precision	NOUN
fnp-8974	67	6	therapies	therapy	NOUN
fnp-8974	67	7	in	in	ADV
fnp-8974	67	8	gb	gb	NOUN
fnp-8974	67	9	targeting	target	VERB
fnp-8974	67	10	oncogenic	oncogenic	ADJ
fnp-8974	67	11	drivers	driver	NOUN
fnp-8974	67	12	highlights	highlight	NOUN
fnp-8974	67	13	the	the	DET
fnp-8974	67	14	need	need	NOUN
fnp-8974	67	15	to	to	PART
fnp-8974	67	16	address	address	VERB
fnp-8974	67	17	ith	ith	PROPN
fnp-8974	67	18	and	and	CCONJ
fnp-8974	67	19	its	its	PRON
fnp-8974	67	20	plasticity	plasticity	NOUN
fnp-8974	67	21	in	in	ADP
fnp-8974	67	22	treatment	treatment	NOUN
fnp-8974	67	23	strategies	strategy	NOUN
fnp-8974	67	24	.	.	PUNCT
fnp-8974	68	1	integration	integration	NOUN
fnp-8974	68	2	of	of	ADP
fnp-8974	68	3	multi	multi	ADJ
fnp-8974	68	4	-	-	ADJ
fnp-8974	68	5	omics	omics	ADJ
fnp-8974	68	6	single	single	ADJ
fnp-8974	68	7	-	-	PUNCT
fnp-8974	68	8	cell	cell	NOUN
fnp-8974	68	9	data	datum	NOUN
fnp-8974	68	10	enabled	enable	VERB
fnp-8974	68	11	the	the	DET
fnp-8974	68	12	resolution	resolution	NOUN
fnp-8974	68	13	of	of	ADP
fnp-8974	68	14	ith	ith	PROPN
fnp-8974	68	15	in	in	ADP
fnp-8974	68	16	gb	gb	PRON
fnp-8974	68	17	and	and	CCONJ
fnp-8974	68	18	the	the	DET
fnp-8974	68	19	development	development	NOUN
fnp-8974	68	20	of	of	ADP
fnp-8974	68	21	a	a	DET
fnp-8974	68	22	deconvolution	deconvolution	NOUN
fnp-8974	68	23	method	method	NOUN
fnp-8974	68	24	which	which	PRON
fnp-8974	68	25	can	can	AUX
fnp-8974	68	26	accurately	accurately	ADV
fnp-8974	68	27	predict	predict	VERB
fnp-8974	68	28	cell	cell	NOUN
fnp-8974	68	29	type	type	NOUN
fnp-8974	68	30	and	and	CCONJ
fnp-8974	68	31	malignant	malignant	ADJ
fnp-8974	68	32	cell	cell	NOUN
fnp-8974	68	33	state	state	NOUN
fnp-8974	68	34	compositions	composition	NOUN
fnp-8974	68	35	from	from	ADP
fnp-8974	68	36	bulk	bulk	ADJ
fnp-8974	68	37	methylation	methylation	NOUN
fnp-8974	68	38	array	array	NOUN
fnp-8974	68	39	data	datum	NOUN
fnp-8974	68	40	.	.	PUNCT
fnp-8974	69	1	previous	previous	ADJ
fnp-8974	69	2	analyses	analysis	NOUN
fnp-8974	69	3	revealed	reveal	VERB
fnp-8974	69	4	distinct	distinct	ADJ
fnp-8974	69	5	vulnerabilities	vulnerability	NOUN
fnp-8974	69	6	in	in	ADP
fnp-8974	69	7	deconvolved	deconvolved	ADJ
fnp-8974	69	8	cell	cell	NOUN
fnp-8974	69	9	states	state	NOUN
fnp-8974	69	10	,	,	PUNCT
fnp-8974	69	11	identifying	identify	VERB
fnp-8974	69	12	them	they	PRON
fnp-8974	69	13	as	as	ADP
fnp-8974	69	14	potentially	potentially	ADV
fnp-8974	69	15	targetable	targetable	ADJ
fnp-8974	69	16	biomarkers	biomarker	NOUN
fnp-8974	69	17	.	.	PUNCT
fnp-8974	70	1	we	we	PRON
fnp-8974	70	2	believe	believe	VERB
fnp-8974	70	3	cell	cell	NOUN
fnp-8974	70	4	state	state	NOUN
fnp-8974	70	5	monitoring	monitoring	NOUN
fnp-8974	70	6	holds	hold	VERB
fnp-8974	70	7	significant	significant	ADJ
fnp-8974	70	8	potential	potential	NOUN
fnp-8974	70	9	for	for	ADP
fnp-8974	70	10	improving	improve	VERB
fnp-8974	70	11	therapy	therapy	NOUN
fnp-8974	70	12	guidance	guidance	NOUN
fnp-8974	70	13	but	but	CCONJ
fnp-8974	70	14	requires	require	VERB
fnp-8974	70	15	rapid	rapid	ADJ
fnp-8974	70	16	,	,	PUNCT
fnp-8974	70	17	scalable	scalable	ADJ
fnp-8974	70	18	,	,	PUNCT
fnp-8974	70	19	and	and	CCONJ
fnp-8974	70	20	cost	cost	NOUN
fnp-8974	70	21	-	-	PUNCT
fnp-8974	70	22	effective	effective	ADJ
fnp-8974	70	23	screening	screening	NOUN
fnp-8974	70	24	methods	method	NOUN
fnp-8974	70	25	.	.	PUNCT
fnp-8974	71	1	objective(s	objective(s	NOUN
fnp-8974	71	2	):	):	PUNCT
fnp-8974	71	3	establishing	establish	VERB
fnp-8974	71	4	a	a	DET
fnp-8974	71	5	functional	functional	ADJ
fnp-8974	71	6	precision	precision	NOUN
fnp-8974	71	7	medicine	medicine	NOUN
fnp-8974	71	8	platform	platform	NOUN
fnp-8974	71	9	modelling	modelling	NOUN
fnp-8974	71	10	cell	cell	NOUN
fnp-8974	71	11	state	state	NOUN
fnp-8974	71	12	responses	response	NOUN
fnp-8974	71	13	in	in	ADP
fnp-8974	71	14	patient	patient	NOUN
fnp-8974	71	15	-	-	PUNCT
fnp-8974	71	16	derived	derive	VERB
fnp-8974	71	17	cell	cell	NOUN
fnp-8974	71	18	lines	line	NOUN
fnp-8974	71	19	.	.	PUNCT
fnp-8974	72	1	enabling	enable	VERB
fnp-8974	72	2	cell	cell	NOUN
fnp-8974	72	3	state	state	NOUN
fnp-8974	72	4	deconvolution	deconvolution	NOUN
fnp-8974	72	5	from	from	ADP
fnp-8974	72	6	sparse	sparse	ADJ
fnp-8974	72	7	methylation	methylation	NOUN
fnp-8974	72	8	data	datum	NOUN
fnp-8974	72	9	like	like	ADP
fnp-8974	72	10	liquid	liquid	ADJ
fnp-8974	72	11	biopsies	biopsy	NOUN
fnp-8974	72	12	revolutionizing	revolutionize	VERB
fnp-8974	72	13	the	the	DET
fnp-8974	72	14	ability	ability	NOUN
fnp-8974	72	15	to	to	PART
fnp-8974	72	16	longitudinally	longitudinally	ADV
fnp-8974	72	17	monitor	monitor	VERB
fnp-8974	72	18	gb	gb	ADP
fnp-8974	72	19	patients	patient	NOUN
fnp-8974	72	20	throughout	throughout	ADP
fnp-8974	72	21	their	their	PRON
fnp-8974	72	22	treatment	treatment	NOUN
fnp-8974	72	23	.	.	PUNCT
fnp-8974	73	1	method(s	method(	VERB
fnp-8974	73	2	):	):	PUNCT
fnp-8974	73	3	methylation	methylation	NOUN
fnp-8974	73	4	-	-	PUNCT
fnp-8974	73	5	based	base	VERB
fnp-8974	73	6	cell	cell	NOUN
fnp-8974	73	7	state	state	NOUN
fnp-8974	73	8	deconvolution	deconvolution	NOUN
fnp-8974	73	9	from	from	ADP
fnp-8974	73	10	oxford	oxford	PROPN
fnp-8974	73	11	nanopore	nanopore	ADJ
fnp-8974	73	12	technologies	technology	NOUN
fnp-8974	73	13	(	(	PUNCT
fnp-8974	73	14	ont	ont	NOUN
fnp-8974	73	15	)	)	PUNCT
fnp-8974	73	16	sequencing	sequence	VERB
fnp-8974	73	17	data	datum	NOUN
fnp-8974	73	18	.	.	PUNCT
fnp-8974	74	1	result(s	result(s	PROPN
fnp-8974	74	2	):	):	PUNCT
fnp-8974	74	3	we	we	PRON
fnp-8974	74	4	adapted	adapt	VERB
fnp-8974	74	5	cell	cell	NOUN
fnp-8974	74	6	state	state	NOUN
fnp-8974	74	7	deconvolution	deconvolution	NOUN
fnp-8974	74	8	to	to	PART
fnp-8974	74	9	ont	ont	VERB
fnp-8974	74	10	sequencing	sequence	VERB
fnp-8974	74	11	data	datum	NOUN
fnp-8974	74	12	and	and	CCONJ
fnp-8974	74	13	subsequently	subsequently	ADV
fnp-8974	74	14	evaluated	evaluate	VERB
fnp-8974	74	15	cell	cell	NOUN
fnp-8974	74	16	state	state	NOUN
fnp-8974	74	17	predictions	prediction	NOUN
fnp-8974	74	18	in	in	ADP
fnp-8974	74	19	a	a	DET
fnp-8974	74	20	cohort	cohort	NOUN
fnp-8974	74	21	of	of	ADP
fnp-8974	74	22	59	59	NUM
fnp-8974	74	23	ont	ont	NOUN
fnp-8974	74	24	sequencing	sequencing	NOUN
fnp-8974	74	25	samples	sample	NOUN
fnp-8974	74	26	from	from	ADP
fnp-8974	74	27	fresh	fresh	ADJ
fnp-8974	74	28	-	-	PUNCT
fnp-8974	74	29	frozen	frozen	ADJ
fnp-8974	74	30	tissue	tissue	NOUN
fnp-8974	74	31	with	with	ADP
fnp-8974	74	32	corresponding	corresponding	ADJ
fnp-8974	74	33	methylation	methylation	NOUN
fnp-8974	74	34	array	array	NOUN
fnp-8974	74	35	data	datum	NOUN
fnp-8974	74	36	.	.	PUNCT
fnp-8974	75	1	comparative	comparative	ADJ
fnp-8974	75	2	analysis	analysis	NOUN
fnp-8974	75	3	revealed	reveal	VERB
fnp-8974	75	4	100	100	NUM
fnp-8974	75	5	 	 	SPACE
fnp-8974	75	6	%	%	NOUN
fnp-8974	75	7	concordance	concordance	NOUN
fnp-8974	75	8	in	in	ADP
fnp-8974	75	9	the	the	DET
fnp-8974	75	10	identification	identification	NOUN
fnp-8974	75	11	of	of	ADP
fnp-8974	75	12	the	the	DET
fnp-8974	75	13	predominant	predominant	ADJ
fnp-8974	75	14	cell	cell	NOUN
fnp-8974	75	15	state	state	NOUN
fnp-8974	75	16	.	.	PUNCT
fnp-8974	76	1	we	we	PRON
fnp-8974	76	2	established	establish	VERB
fnp-8974	76	3	the	the	DET
fnp-8974	76	4	first	first	ADJ
fnp-8974	76	5	standardized	standardized	ADJ
fnp-8974	76	6	pipeline	pipeline	NOUN
fnp-8974	76	7	–	–	PUNCT
fnp-8974	76	8	csgo	csgo	NOUN
fnp-8974	76	9	(	(	PUNCT
fnp-8974	76	10	cellular	cellular	ADJ
fnp-8974	76	11	state	state	NOUN
fnp-8974	76	12	resolution	resolution	NOUN
fnp-8974	76	13	for	for	ADP
fnp-8974	76	14	glioblastoma	glioblastoma	NOUN
fnp-8974	76	15	oncology)–to	oncology)–to	VERB
fnp-8974	76	16	rapidly	rapidly	ADV
fnp-8974	76	17	resolve	resolve	VERB
fnp-8974	76	18	the	the	DET
fnp-8974	76	19	cellular	cellular	ADJ
fnp-8974	76	20	states	state	NOUN
fnp-8974	76	21	of	of	ADP
fnp-8974	76	22	gb	gb	NOUN
fnp-8974	76	23	patients	patient	NOUN
fnp-8974	76	24	.	.	PUNCT
fnp-8974	77	1	conclusion(s	conclusion(s	NOUN
fnp-8974	77	2	):	):	PUNCT
fnp-8974	77	3	our	our	PRON
fnp-8974	77	4	pipeline	pipeline	NOUN
fnp-8974	77	5	lays	lay	VERB
fnp-8974	77	6	the	the	DET
fnp-8974	77	7	foundation	foundation	NOUN
fnp-8974	77	8	for	for	ADP
fnp-8974	77	9	the	the	DET
fnp-8974	77	10	integration	integration	NOUN
fnp-8974	77	11	of	of	ADP
fnp-8974	77	12	ith	ith	PROPN
fnp-8974	77	13	in	in	ADP
fnp-8974	77	14	clinical	clinical	ADJ
fnp-8974	77	15	decision	decision	NOUN
fnp-8974	77	16	making	making	NOUN
fnp-8974	77	17	and	and	CCONJ
fnp-8974	77	18	drug	drug	NOUN
fnp-8974	77	19	response	response	NOUN
fnp-8974	77	20	monitoring	monitoring	NOUN
fnp-8974	77	21	.	.	PUNCT
fnp-8974	78	1	p05	p05	PROPN
fnp-8974	78	2	free	free	ADJ
fnp-8974	78	3	neuropathol	neuropathol	NOUN
fnp-8974	78	4	6:17:12	6:17:12	NUM
fnp-8974	78	5	foundation	foundation	NOUN
fnp-8974	78	6	models	model	NOUN
fnp-8974	78	7	encode	encode	VERB
fnp-8974	78	8	technical	technical	ADJ
fnp-8974	78	9	biases	bias	NOUN
fnp-8974	78	10	:	:	PUNCT
fnp-8974	78	11	a	a	DET
fnp-8974	78	12	hidden	hidden	ADJ
fnp-8974	78	13	risk	risk	NOUN
fnp-8974	78	14	for	for	ADP
fnp-8974	78	15	multi	multi	ADJ
fnp-8974	78	16	-	-	ADJ
fnp-8974	78	17	institutional	institutional	ADJ
fnp-8974	78	18	histopathology	histopathology	NOUN
fnp-8974	78	19	ai	ai	VERB
fnp-8974	78	20	jannik	jannik	PROPN
fnp-8974	78	21	sehring1	sehring1	PROPN
fnp-8974	78	22	,	,	PUNCT
fnp-8974	78	23	hildergard	hildergard	NOUN
fnp-8974	78	24	dohmen1	dohmen1	PROPN
fnp-8974	78	25	,	,	PUNCT
fnp-8974	78	26	kai	kai	PROPN
fnp-8974	78	27	schmid1	schmid1	PROPN
fnp-8974	78	28	,	,	PUNCT
fnp-8974	78	29	gudrun	gudrun	PROPN
fnp-8974	78	30	schmidt1	schmidt1	PROPN
fnp-8974	78	31	,	,	PUNCT
fnp-8974	78	32	friederike	friederike	INTJ
fnp-8974	78	33	liesche	liesche	NOUN
fnp-8974	78	34	-	-	PUNCT
fnp-8974	78	35	starnecker2	starnecker2	PROPN
fnp-8974	78	36	,	,	PUNCT
fnp-8974	78	37	jörg	jörg	PROPN
fnp-8974	78	38	felsberg3	felsberg3	PROPN
fnp-8974	78	39	,	,	PUNCT
fnp-8974	78	40	guido	guido	PROPN
fnp-8974	78	41	reifenberger3	reifenberger3	PROPN
fnp-8974	78	42	,	,	PUNCT
fnp-8974	78	43	moritz	moritz	PROPN
fnp-8974	78	44	armbrust4	armbrust4	PROPN
fnp-8974	78	45	,	,	PUNCT
fnp-8974	78	46	katharina	katharina	PROPN
fnp-8974	78	47	j.	j.	PROPN
fnp-8974	78	48	weber4	weber4	PROPN
fnp-8974	78	49	,	,	PUNCT
fnp-8974	78	50	karl	karl	PROPN
fnp-8974	78	51	heinz	heinz	PROPN
fnp-8974	78	52	plate4	plate4	PROPN
fnp-8974	78	53	,	,	PUNCT
fnp-8974	78	54	christian	christian	ADJ
fnp-8974	78	55	mawrin5	mawrin5	NOUN
fnp-8974	78	56	,	,	PUNCT
fnp-8974	78	57	markus	markus	PROPN
fnp-8974	78	58	j.	j.	PROPN
fnp-8974	78	59	riemenschneider6	riemenschneider6	PROPN
fnp-8974	78	60	,	,	PUNCT
fnp-8974	78	61	david	david	PROPN
fnp-8974	78	62	capper7	capper7	PROPN
fnp-8974	78	63	,	,	PUNCT
fnp-8974	78	64	frank	frank	PROPN
fnp-8974	78	65	heppner7	heppner7	PROPN
fnp-8974	78	66	,	,	PUNCT
fnp-8974	78	67	stefan	stefan	PROPN
fnp-8974	78	68	hamelmann8	hamelmann8	PROPN
fnp-8974	78	69	,	,	PUNCT
fnp-8974	78	70	felix	felix	PROPN
fnp-8974	78	71	sahm8	sahm8	PROPN
fnp-8974	78	72	,	,	PUNCT
fnp-8974	78	73	daniel	daniel	PROPN
fnp-8974	78	74	amsel1	amsel1	PROPN
fnp-8974	78	75	,	,	PUNCT
fnp-8974	78	76	till	till	SCONJ
fnp-8974	78	77	acker1	acker1	NOUN
fnp-8974	78	78	1	1	NUM
fnp-8974	78	79	justus	justus	PROPN
fnp-8974	78	80	-	-	PUNCT
fnp-8974	78	81	liebig	liebig	NOUN
fnp-8974	78	82	-	-	PUNCT
fnp-8974	78	83	university	university	NOUN
fnp-8974	78	84	giessen	giessen	NOUN
fnp-8974	78	85	,	,	PUNCT
fnp-8974	78	86	institute	institute	NOUN
fnp-8974	78	87	of	of	ADP
fnp-8974	78	88	neuropathology	neuropathology	NOUN
fnp-8974	78	89	,	,	PUNCT
fnp-8974	78	90	giessen	giessen	VERB
fnp-8974	78	91	,	,	PUNCT
fnp-8974	78	92	germany	germany	PROPN
fnp-8974	78	93	2	2	NUM
fnp-8974	78	94	university	university	NOUN
fnp-8974	78	95	of	of	ADP
fnp-8974	78	96	augsburg	augsburg	PROPN
fnp-8974	78	97	,	,	PUNCT
fnp-8974	78	98	medical	medical	ADJ
fnp-8974	78	99	faculty	faculty	NOUN
fnp-8974	78	100	,	,	PUNCT
fnp-8974	78	101	department	department	NOUN
fnp-8974	78	102	of	of	ADP
fnp-8974	78	103	neuropathology	neuropathology	NOUN
fnp-8974	78	104	,	,	PUNCT
fnp-8974	78	105	augsburg	augsburg	PROPN
fnp-8974	78	106	,	,	PUNCT
fnp-8974	78	107	germany	germany	PROPN
fnp-8974	78	108	3	3	NUM
fnp-8974	78	109	university	university	PROPN
fnp-8974	78	110	hospital	hospital	NOUN
fnp-8974	78	111	düsseldorf	düsseldorf	PROPN
fnp-8974	78	112	,	,	PUNCT
fnp-8974	78	113	institute	institute	PROPN
fnp-8974	78	114	of	of	ADP
fnp-8974	78	115	neuropathology	neuropathology	PROPN
fnp-8974	78	116	,	,	PUNCT
fnp-8974	78	117	düsseldorf	düsseldorf	PROPN
fnp-8974	78	118	,	,	PUNCT
fnp-8974	78	119	germany	germany	PROPN
fnp-8974	78	120	4	4	NUM
fnp-8974	78	121	university	university	NOUN
fnp-8974	78	122	hospital	hospital	NOUN
fnp-8974	78	123	frankfurt	frankfurt	PROPN
fnp-8974	78	124	,	,	PUNCT
fnp-8974	78	125	neurological	neurological	ADJ
fnp-8974	78	126	institute	institute	NOUN
fnp-8974	78	127	(	(	PUNCT
fnp-8974	78	128	edinger	edinger	PROPN
fnp-8974	78	129	institute	institute	PROPN
fnp-8974	78	130	)	)	PUNCT
fnp-8974	78	131	,	,	PUNCT
fnp-8974	78	132	frankfurt	frankfurt	PROPN
fnp-8974	78	133	am	be	AUX
fnp-8974	78	134	main	main	ADJ
fnp-8974	78	135	,	,	PUNCT
fnp-8974	78	136	germany	germany	PROPN
fnp-8974	78	137	5	5	NUM
fnp-8974	78	138	otto	otto	PROPN
fnp-8974	78	139	-	-	PUNCT
fnp-8974	78	140	von	von	PROPN
fnp-8974	78	141	-	-	PUNCT
fnp-8974	78	142	guericke	guericke	PROPN
fnp-8974	78	143	university	university	NOUN
fnp-8974	78	144	magdeburg	magdeburg	PROPN
fnp-8974	78	145	,	,	PUNCT
fnp-8974	78	146	institute	institute	PROPN
fnp-8974	78	147	of	of	ADP
fnp-8974	78	148	neuropathology	neuropathology	PROPN
fnp-8974	78	149	,	,	PUNCT
fnp-8974	78	150	magdeburg	magdeburg	PROPN
fnp-8974	78	151	,	,	PUNCT
fnp-8974	78	152	germany	germany	PROPN
fnp-8974	78	153	6	6	NUM
fnp-8974	78	154	regensburg	regensburg	PROPN
fnp-8974	78	155	university	university	NOUN
fnp-8974	78	156	hospital	hospital	NOUN
fnp-8974	78	157	,	,	PUNCT
fnp-8974	78	158	department	department	NOUN
fnp-8974	78	159	of	of	ADP
fnp-8974	78	160	neuropathology	neuropathology	NOUN
fnp-8974	78	161	,	,	PUNCT
fnp-8974	78	162	regensburg	regensburg	PROPN
fnp-8974	78	163	,	,	PUNCT
fnp-8974	78	164	germany	germany	PROPN
fnp-8974	78	165	7	7	NUM
fnp-8974	78	166	charité	charité	PROPN
fnp-8974	78	167	berlin	berlin	PROPN
fnp-8974	78	168	,	,	PUNCT
fnp-8974	78	169	department	department	NOUN
fnp-8974	78	170	of	of	ADP
fnp-8974	78	171	neuropathology	neuropathology	NOUN
fnp-8974	78	172	,	,	PUNCT
fnp-8974	78	173	berlin	berlin	PROPN
fnp-8974	78	174	,	,	PUNCT
fnp-8974	78	175	germany	germany	PROPN
fnp-8974	78	176	8	8	NUM
fnp-8974	78	177	heidelberg	heidelberg	PROPN
fnp-8974	78	178	university	university	PROPN
fnp-8974	78	179	hospital	hospital	NOUN
fnp-8974	78	180	,	,	PUNCT
fnp-8974	78	181	department	department	NOUN
fnp-8974	78	182	of	of	ADP
fnp-8974	78	183	neuropathology	neuropathology	NOUN
fnp-8974	78	184	,	,	PUNCT
fnp-8974	78	185	heidelberg	heidelberg	PROPN
fnp-8974	78	186	,	,	PUNCT
fnp-8974	78	187	germany	germany	PROPN
fnp-8974	78	188	background	background	NOUN
fnp-8974	78	189	:	:	PUNCT
fnp-8974	78	190	foundation	foundation	NOUN
fnp-8974	78	191	models	model	NOUN
fnp-8974	78	192	are	be	AUX
fnp-8974	78	193	widely	widely	ADV
fnp-8974	78	194	used	use	VERB
fnp-8974	78	195	in	in	ADP
fnp-8974	78	196	histopathological	histopathological	ADJ
fnp-8974	78	197	ai	ai	VERB
fnp-8974	78	198	due	due	ADP
fnp-8974	78	199	to	to	ADP
fnp-8974	78	200	their	their	PRON
fnp-8974	78	201	capacity	capacity	NOUN
fnp-8974	78	202	to	to	PART
fnp-8974	78	203	encode	encode	VERB
fnp-8974	78	204	complex	complex	ADJ
fnp-8974	78	205	morphological	morphological	ADJ
fnp-8974	78	206	features	feature	NOUN
fnp-8974	78	207	.	.	PUNCT
fnp-8974	79	1	however	however	ADV
fnp-8974	79	2	,	,	PUNCT
fnp-8974	79	3	these	these	DET
fnp-8974	79	4	models	model	NOUN
fnp-8974	79	5	may	may	AUX
fnp-8974	79	6	inadvertently	inadvertently	ADV
fnp-8974	79	7	capture	capture	VERB
fnp-8974	79	8	uninformative	uninformative	ADJ
fnp-8974	79	9	variation	variation	NOUN
fnp-8974	79	10	,	,	PUNCT
fnp-8974	79	11	including	include	VERB
fnp-8974	79	12	technical	technical	ADJ
fnp-8974	79	13	disparities	disparity	NOUN
fnp-8974	79	14	in	in	ADP
fnp-8974	79	15	histological	histological	ADJ
fnp-8974	79	16	staining	staining	NOUN
fnp-8974	79	17	and	and	CCONJ
fnp-8974	79	18	digitization	digitization	NOUN
fnp-8974	79	19	,	,	PUNCT
fnp-8974	79	20	potentially	potentially	ADV
fnp-8974	79	21	compromising	compromise	VERB
fnp-8974	79	22	model	model	NOUN
fnp-8974	79	23	generalizability	generalizability	NOUN
fnp-8974	79	24	.	.	PUNCT
fnp-8974	80	1	this	this	PRON
fnp-8974	80	2	is	be	AUX
fnp-8974	80	3	particularly	particularly	ADV
fnp-8974	80	4	relevant	relevant	ADJ
fnp-8974	80	5	for	for	ADP
fnp-8974	80	6	multi	multi	ADJ
fnp-8974	80	7	-	-	ADJ
fnp-8974	80	8	institutional	institutional	ADJ
fnp-8974	80	9	studies	study	NOUN
fnp-8974	80	10	and	and	CCONJ
fnp-8974	80	11	downstream	downstream	ADJ
fnp-8974	80	12	clinical	clinical	ADJ
fnp-8974	80	13	applications	application	NOUN
fnp-8974	80	14	,	,	PUNCT
fnp-8974	80	15	which	which	PRON
fnp-8974	80	16	require	require	VERB
fnp-8974	80	17	both	both	DET
fnp-8974	80	18	robust	robust	ADJ
fnp-8974	80	19	cross	cross	ADJ
fnp-8974	80	20	-	-	ADJ
fnp-8974	80	21	site	site	ADJ
fnp-8974	80	22	performance	performance	NOUN
fnp-8974	80	23	and	and	CCONJ
fnp-8974	80	24	reliable	reliable	ADJ
fnp-8974	80	25	transferability	transferability	NOUN
fnp-8974	80	26	to	to	ADP
fnp-8974	80	27	individual	individual	ADJ
fnp-8974	80	28	laboratories	laboratory	NOUN
fnp-8974	80	29	.	.	PUNCT
fnp-8974	81	1	objective(s	objective(s	NOUN
fnp-8974	81	2	):	):	PUNCT
fnp-8974	81	3	determine	determine	VERB
fnp-8974	81	4	whether	whether	SCONJ
fnp-8974	81	5	pathological	pathological	ADJ
fnp-8974	81	6	foundation	foundation	NOUN
fnp-8974	81	7	models	model	NOUN
fnp-8974	81	8	encode	encode	VERB
fnp-8974	81	9	technical	technical	ADJ
fnp-8974	81	10	biases	bias	NOUN
fnp-8974	81	11	.	.	PUNCT
fnp-8974	82	1	method(s	method(	VERB
fnp-8974	82	2	):	):	PUNCT
fnp-8974	82	3	a	a	DET
fnp-8974	82	4	large	large	ADJ
fnp-8974	82	5	multi	multi	ADJ
fnp-8974	82	6	-	-	ADJ
fnp-8974	82	7	institutional	institutional	ADJ
fnp-8974	82	8	dataset	dataset	NOUN
fnp-8974	82	9	of	of	ADP
fnp-8974	82	10	h&e	h&e	PROPN
fnp-8974	82	11	-	-	PUNCT
fnp-8974	82	12	stained	stain	VERB
fnp-8974	82	13	meningioma	meningioma	NOUN
fnp-8974	82	14	sections	section	NOUN
fnp-8974	82	15	(	(	PUNCT
fnp-8974	82	16	n	n	CCONJ
fnp-8974	82	17	 	 	SPACE
fnp-8974	82	18	=	=	NOUN
fnp-8974	82	19	 	 	SPACE
fnp-8974	82	20	180	180	NUM
fnp-8974	82	21	)	)	PUNCT
fnp-8974	82	22	was	be	AUX
fnp-8974	82	23	compiled	compile	VERB
fnp-8974	82	24	,	,	PUNCT
fnp-8974	82	25	with	with	SCONJ
fnp-8974	82	26	each	each	DET
fnp-8974	82	27	case	case	NOUN
fnp-8974	82	28	stained	stain	VERB
fnp-8974	82	29	at	at	ADP
fnp-8974	82	30	three	three	NUM
fnp-8974	82	31	different	different	ADJ
fnp-8974	82	32	institutes	institute	NOUN
fnp-8974	82	33	and	and	CCONJ
fnp-8974	82	34	digitized	digitize	VERB
fnp-8974	82	35	using	use	VERB
fnp-8974	82	36	three	three	NUM
fnp-8974	82	37	different	different	ADJ
fnp-8974	82	38	scanners	scanner	NOUN
fnp-8974	82	39	.	.	PUNCT
fnp-8974	83	1	after	after	ADP
fnp-8974	83	2	image	image	NOUN
fnp-8974	83	3	registration	registration	NOUN
fnp-8974	83	4	,	,	PUNCT
fnp-8974	83	5	the	the	DET
fnp-8974	83	6	feature	feature	NOUN
fnp-8974	83	7	embeddings	embedding	NOUN
fnp-8974	83	8	of	of	ADP
fnp-8974	83	9	100	100	NUM
fnp-8974	83	10	patches	patch	NOUN
fnp-8974	83	11	per	per	ADP
fnp-8974	83	12	slide	slide	NOUN
fnp-8974	83	13	were	be	AUX
fnp-8974	83	14	encoded	encode	VERB
fnp-8974	83	15	using	use	VERB
fnp-8974	83	16	seven	seven	NUM
fnp-8974	83	17	different	different	ADJ
fnp-8974	83	18	foundation	foundation	NOUN
fnp-8974	83	19	models	model	NOUN
fnp-8974	83	20	.	.	PUNCT
fnp-8974	84	1	to	to	PART
fnp-8974	84	2	quantify	quantify	VERB
fnp-8974	84	3	the	the	DET
fnp-8974	84	4	encoding	encoding	NOUN
fnp-8974	84	5	of	of	ADP
fnp-8974	84	6	technical	technical	ADJ
fnp-8974	84	7	variables	variable	NOUN
fnp-8974	84	8	,	,	PUNCT
fnp-8974	84	9	we	we	PRON
fnp-8974	84	10	trained	train	VERB
fnp-8974	84	11	a	a	DET
fnp-8974	84	12	multi	multi	ADJ
fnp-8974	84	13	-	-	ADJ
fnp-8974	84	14	layer	layer	ADJ
fnp-8974	84	15	perceptron	perceptron	NOUN
fnp-8974	84	16	to	to	PART
fnp-8974	84	17	classify	classify	VERB
fnp-8974	84	18	either	either	CCONJ
fnp-8974	84	19	the	the	DET
fnp-8974	84	20	scanner	scanner	NOUN
fnp-8974	84	21	or	or	CCONJ
fnp-8974	84	22	the	the	DET
fnp-8974	84	23	staining	stain	VERB
fnp-8974	84	24	institute	institute	NOUN
fnp-8974	84	25	from	from	ADP
fnp-8974	84	26	the	the	DET
fnp-8974	84	27	embeddings	embedding	NOUN
fnp-8974	84	28	,	,	PUNCT
fnp-8974	84	29	keeping	keep	VERB
fnp-8974	84	30	the	the	DET
fnp-8974	84	31	other	other	ADJ
fnp-8974	84	32	variables	variable	NOUN
fnp-8974	84	33	constant	constant	ADJ
fnp-8974	84	34	.	.	PUNCT
fnp-8974	85	1	result(s	result(s	NOUN
fnp-8974	85	2	):	):	PUNCT
fnp-8974	85	3	classification	classification	NOUN
fnp-8974	85	4	accuracies	accuracy	NOUN
fnp-8974	85	5	were	be	AUX
fnp-8974	85	6	evaluated	evaluate	VERB
fnp-8974	85	7	across	across	ADP
fnp-8974	85	8	a	a	DET
fnp-8974	85	9	five	five	NUM
fnp-8974	85	10	-	-	ADJ
fnp-8974	85	11	fold	fold	ADJ
fnp-8974	85	12	cross	cross	NOUN
fnp-8974	85	13	-	-	NOUN
fnp-8974	85	14	validation	validation	NOUN
fnp-8974	85	15	for	for	ADP
fnp-8974	85	16	each	each	DET
fnp-8974	85	17	foundation	foundation	NOUN
fnp-8974	85	18	model	model	NOUN
fnp-8974	85	19	.	.	PUNCT
fnp-8974	86	1	scanner	scanner	NOUN
fnp-8974	86	2	prediction	prediction	NOUN
fnp-8974	86	3	yielded	yield	VERB
fnp-8974	86	4	very	very	ADV
fnp-8974	86	5	high	high	ADJ
fnp-8974	86	6	accuracy	accuracy	NOUN
fnp-8974	86	7	(	(	PUNCT
fnp-8974	86	8	0.98–0.99	0.98–0.99	NUM
fnp-8974	86	9	)	)	PUNCT
fnp-8974	86	10	,	,	PUNCT
fnp-8974	86	11	while	while	SCONJ
fnp-8974	86	12	institute	institute	NOUN
fnp-8974	86	13	prediction	prediction	NOUN
fnp-8974	86	14	ranged	range	VERB
fnp-8974	86	15	from	from	ADP
fnp-8974	86	16	0.73	0.73	NUM
fnp-8974	86	17	to	to	ADP
fnp-8974	86	18	0.91	0.91	NUM
fnp-8974	86	19	,	,	PUNCT
fnp-8974	86	20	depending	depend	VERB
fnp-8974	86	21	on	on	ADP
fnp-8974	86	22	the	the	DET
fnp-8974	86	23	foundation	foundation	NOUN
fnp-8974	86	24	model	model	NOUN
fnp-8974	86	25	used	use	VERB
fnp-8974	86	26	.	.	PUNCT
fnp-8974	87	1	conclusion(s	conclusion(s	NOUN
fnp-8974	87	2	):	):	PUNCT
fnp-8974	87	3	foundation	foundation	NOUN
fnp-8974	87	4	models	model	NOUN
fnp-8974	87	5	encode	encode	VERB
fnp-8974	87	6	substantial	substantial	ADJ
fnp-8974	87	7	technical	technical	ADJ
fnp-8974	87	8	variation	variation	NOUN
fnp-8974	87	9	,	,	PUNCT
fnp-8974	87	10	even	even	ADV
fnp-8974	87	11	in	in	ADP
fnp-8974	87	12	controlled	control	VERB
fnp-8974	87	13	multi	multi	ADJ
fnp-8974	87	14	-	-	ADJ
fnp-8974	87	15	center	center	ADJ
fnp-8974	87	16	datasets	dataset	NOUN
fnp-8974	87	17	.	.	PUNCT
fnp-8974	88	1	this	this	PRON
fnp-8974	88	2	raises	raise	VERB
fnp-8974	88	3	concerns	concern	NOUN
fnp-8974	88	4	regarding	regard	VERB
fnp-8974	88	5	interpretability	interpretability	NOUN
fnp-8974	88	6	and	and	CCONJ
fnp-8974	88	7	robustness	robustness	NOUN
fnp-8974	88	8	,	,	PUNCT
fnp-8974	88	9	particularly	particularly	ADV
fnp-8974	88	10	when	when	SCONJ
fnp-8974	88	11	confounders	confounder	NOUN
fnp-8974	88	12	correlate	correlate	VERB
fnp-8974	88	13	with	with	ADP
fnp-8974	88	14	clinical	clinical	ADJ
fnp-8974	88	15	labels	label	NOUN
fnp-8974	88	16	.	.	PUNCT
fnp-8974	89	1	these	these	DET
fnp-8974	89	2	biases	bias	NOUN
fnp-8974	89	3	must	must	AUX
fnp-8974	89	4	be	be	AUX
fnp-8974	89	5	considered	consider	VERB
fnp-8974	89	6	in	in	ADP
fnp-8974	89	7	computational	computational	ADJ
fnp-8974	89	8	pathology	pathology	NOUN
fnp-8974	89	9	workflows	workflow	VERB
fnp-8974	89	10	to	to	PART
fnp-8974	89	11	avoid	avoid	VERB
fnp-8974	89	12	misleading	misleading	ADJ
fnp-8974	89	13	associations	association	NOUN
fnp-8974	89	14	and	and	CCONJ
fnp-8974	89	15	to	to	PART
fnp-8974	89	16	ensure	ensure	VERB
fnp-8974	89	17	that	that	SCONJ
fnp-8974	89	18	models	model	NOUN
fnp-8974	89	19	can	can	AUX
fnp-8974	89	20	be	be	AUX
fnp-8974	89	21	both	both	PRON
fnp-8974	89	22	generalized	generalize	VERB
fnp-8974	89	23	across	across	ADP
fnp-8974	89	24	sites	site	NOUN
fnp-8974	89	25	and	and	CCONJ
fnp-8974	89	26	reliably	reliably	ADV
fnp-8974	89	27	deployed	deploy	VERB
fnp-8974	89	28	in	in	ADP
fnp-8974	89	29	individual	individual	ADJ
fnp-8974	89	30	diagnostic	diagnostic	ADJ
fnp-8974	89	31	settings	setting	NOUN
fnp-8974	89	32	.	.	PUNCT
fnp-8974	90	1	iii	iii	X
fnp-8974	90	2	.	.	PROPN
fnp-8974	90	3	epilepsy	epilepsy	PROPN
fnp-8974	90	4	p06	p06	VERB
fnp-8974	90	5	free	free	ADJ
fnp-8974	90	6	neuropathol	neuropathol	NOUN
fnp-8974	90	7	6:17:14	6:17:14	NUM
fnp-8974	90	8	investigating	investigate	VERB
fnp-8974	90	9	neurological	neurological	ADJ
fnp-8974	90	10	deficits	deficit	NOUN
fnp-8974	90	11	in	in	ADP
fnp-8974	90	12	meis2	meis2	NOUN
fnp-8974	90	13	-	-	PUNCT
fnp-8974	90	14	related	relate	VERB
fnp-8974	90	15	syndrome	syndrome	NOUN
fnp-8974	90	16	using	use	VERB
fnp-8974	90	17	mescs	mesc	NOUN
fnp-8974	90	18	tamara	tamara	PROPN
fnp-8974	90	19	müller1	müller1	PROPN
fnp-8974	90	20	,	,	PUNCT
fnp-8974	90	21	kiana	kiana	PROPN
fnp-8974	90	22	kafi	kafi	PROPN
fnp-8974	90	23	cheraghi1	cheraghi1	PROPN
fnp-8974	90	24	,	,	PUNCT
fnp-8974	90	25	shripriya	shripriya	PROPN
fnp-8974	90	26	bhat1,2	bhat1,2	PROPN
fnp-8974	90	27	,	,	PUNCT
fnp-8974	90	28	ian	ian	PROPN
fnp-8974	90	29	donaldson3	donaldson3	PROPN
fnp-8974	90	30	,	,	PUNCT
fnp-8974	90	31	stefan	stefan	PROPN
fnp-8974	90	32	günther4	günther4	PROPN
fnp-8974	90	33	,	,	PUNCT
fnp-8974	90	34	miguel	miguel	PROPN
fnp-8974	90	35	torres5	torres5	PROPN
fnp-8974	90	36	,	,	PUNCT
fnp-8974	90	37	nicoletta	nicoletta	PROPN
fnp-8974	90	38	bobola6	bobola6	PROPN
fnp-8974	90	39	,	,	PUNCT
fnp-8974	90	40	dorothea	dorothea	PROPN
fnp-8974	90	41	schulte1	schulte1	PROPN
fnp-8974	90	42	1	1	NUM
fnp-8974	90	43	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	90	44	frankfurt	frankfurt	PROPN
fnp-8974	90	45	,	,	PUNCT
fnp-8974	90	46	goethe	goethe	PROPN
fnp-8974	90	47	universität	universität	NOUN
fnp-8974	90	48	;	;	PUNCT
fnp-8974	90	49	neurologisches	neurologisches	PROPN
fnp-8974	90	50	institut	institut	PROPN
fnp-8974	90	51	,	,	PUNCT
fnp-8974	90	52	edinger	edinger	NOUN
fnp-8974	90	53	institut	institut	PROPN
fnp-8974	90	54	,	,	PUNCT
fnp-8974	90	55	frankfurt	frankfurt	PROPN
fnp-8974	90	56	am	be	AUX
fnp-8974	90	57	main	main	ADJ
fnp-8974	90	58	,	,	PUNCT
fnp-8974	90	59	germany	germany	PROPN
fnp-8974	90	60	2	2	NUM
fnp-8974	90	61	university	university	NOUN
fnp-8974	90	62	of	of	ADP
fnp-8974	90	63	bern	bern	PROPN
fnp-8974	90	64	,	,	PUNCT
fnp-8974	90	65	faculty	faculty	NOUN
fnp-8974	90	66	of	of	ADP
fnp-8974	90	67	medicine	medicine	NOUN
fnp-8974	90	68	,	,	PUNCT
fnp-8974	90	69	department	department	NOUN
fnp-8974	90	70	for	for	ADP
fnp-8974	90	71	biomedical	biomedical	ADJ
fnp-8974	90	72	research	research	NOUN
fnp-8974	90	73	(	(	PUNCT
fnp-8974	90	74	dbmr	dbmr	NOUN
fnp-8974	90	75	)	)	PUNCT
fnp-8974	90	76	,	,	PUNCT
fnp-8974	90	77	bern	bern	PROPN
fnp-8974	90	78	,	,	PUNCT
fnp-8974	90	79	switzerland	switzerland	PROPN
fnp-8974	90	80	3	3	NUM
fnp-8974	90	81	university	university	PROPN
fnp-8974	90	82	of	of	ADP
fnp-8974	90	83	manchester	manchester	PROPN
fnp-8974	90	84	,	,	PUNCT
fnp-8974	90	85	faculty	faculty	NOUN
fnp-8974	90	86	of	of	ADP
fnp-8974	90	87	biology	biology	NOUN
fnp-8974	90	88	,	,	PUNCT
fnp-8974	90	89	medicine	medicine	NOUN
fnp-8974	90	90	and	and	CCONJ
fnp-8974	90	91	health	health	NOUN
fnp-8974	90	92	,	,	PUNCT
fnp-8974	90	93	bioinformatics	bioinformatics	NOUN
fnp-8974	90	94	core	core	NOUN
fnp-8974	90	95	facility	facility	NOUN
fnp-8974	90	96	,	,	PUNCT
fnp-8974	90	97	manchester	manchester	PROPN
fnp-8974	90	98	,	,	PUNCT
fnp-8974	90	99	united	united	ADJ
fnp-8974	90	100	kingdom	kingdom	PROPN
fnp-8974	90	101	4	4	NUM
fnp-8974	90	102	max	max	PROPN
fnp-8974	90	103	planck	planck	PROPN
fnp-8974	90	104	institute	institute	PROPN
fnp-8974	90	105	for	for	ADP
fnp-8974	90	106	heart	heart	NOUN
fnp-8974	90	107	and	and	CCONJ
fnp-8974	90	108	lung	lung	NOUN
fnp-8974	90	109	research	research	NOUN
fnp-8974	90	110	,	,	PUNCT
fnp-8974	90	111	bioinformatics	bioinformatics	NOUN
fnp-8974	90	112	and	and	CCONJ
fnp-8974	90	113	deep	deep	ADJ
fnp-8974	90	114	sequencing	sequence	VERB
fnp-8974	90	115	platform	platform	NOUN
fnp-8974	90	116	,	,	PUNCT
fnp-8974	90	117	bad	bad	ADJ
fnp-8974	90	118	nauheim	nauheim	PROPN
fnp-8974	90	119	,	,	PUNCT
fnp-8974	90	120	germany	germany	PROPN
fnp-8974	90	121	5	5	NUM
fnp-8974	90	122	centro	centro	X
fnp-8974	90	123	nacional	nacional	PROPN
fnp-8974	90	124	de	de	X
fnp-8974	90	125	investigaciones	investigaciones	PROPN
fnp-8974	90	126	cardiovasculares	cardiovasculare	NOUN
fnp-8974	90	127	(	(	PUNCT
fnp-8974	90	128	cnic	cnic	ADJ
fnp-8974	90	129	)	)	PUNCT
fnp-8974	90	130	,	,	PUNCT
fnp-8974	90	131	madrid	madrid	PROPN
fnp-8974	90	132	,	,	PUNCT
fnp-8974	90	133	spain	spain	PROPN
fnp-8974	90	134	6	6	NUM
fnp-8974	90	135	university	university	PROPN
fnp-8974	90	136	of	of	ADP
fnp-8974	90	137	manchester	manchester	PROPN
fnp-8974	90	138	,	,	PUNCT
fnp-8974	90	139	faculty	faculty	NOUN
fnp-8974	90	140	of	of	ADP
fnp-8974	90	141	biology	biology	NOUN
fnp-8974	90	142	,	,	PUNCT
fnp-8974	90	143	medicine	medicine	NOUN
fnp-8974	90	144	and	and	CCONJ
fnp-8974	90	145	health	health	NOUN
fnp-8974	90	146	,	,	PUNCT
fnp-8974	90	147	manchester	manchester	PROPN
fnp-8974	90	148	,	,	PUNCT
fnp-8974	90	149	united	united	PROPN
fnp-8974	90	150	kingdom	kingdom	PROPN
fnp-8974	90	151	background	background	NOUN
fnp-8974	90	152	:	:	PUNCT
fnp-8974	90	153	meis2	meis2	ADJ
fnp-8974	90	154	-	-	PUNCT
fnp-8974	90	155	related	relate	VERB
fnp-8974	90	156	syndrome	syndrome	NOUN
fnp-8974	90	157	,	,	PUNCT
fnp-8974	90	158	resulting	result	VERB
fnp-8974	90	159	from	from	ADP
fnp-8974	90	160	heterozygous	heterozygous	ADJ
fnp-8974	90	161	mutation	mutation	NOUN
fnp-8974	90	162	of	of	ADP
fnp-8974	90	163	the	the	DET
fnp-8974	90	164	transcription	transcription	NOUN
fnp-8974	90	165	factor	factor	NOUN
fnp-8974	90	166	meis2	meis2	NOUN
fnp-8974	90	167	,	,	PUNCT
fnp-8974	90	168	is	be	AUX
fnp-8974	90	169	a	a	DET
fnp-8974	90	170	severe	severe	ADJ
fnp-8974	90	171	congenital	congenital	ADJ
fnp-8974	90	172	disorder	disorder	NOUN
fnp-8974	90	173	characterized	characterize	VERB
fnp-8974	90	174	by	by	ADP
fnp-8974	90	175	a	a	DET
fnp-8974	90	176	triad	triad	NOUN
fnp-8974	90	177	of	of	ADP
fnp-8974	90	178	symptoms	symptom	NOUN
fnp-8974	90	179	of	of	ADP
fnp-8974	90	180	cleft	cleft	NOUN
fnp-8974	90	181	palate	palate	NOUN
fnp-8974	90	182	,	,	PUNCT
fnp-8974	90	183	heart	heart	NOUN
fnp-8974	90	184	malformations	malformation	NOUN
fnp-8974	90	185	,	,	PUNCT
fnp-8974	90	186	and	and	CCONJ
fnp-8974	90	187	neurological	neurological	ADJ
fnp-8974	90	188	deficits	deficit	NOUN
fnp-8974	90	189	.	.	PUNCT
fnp-8974	91	1	the	the	DET
fnp-8974	91	2	neurological	neurological	ADJ
fnp-8974	91	3	side	side	NOUN
fnp-8974	91	4	of	of	ADP
fnp-8974	91	5	this	this	DET
fnp-8974	91	6	disorder	disorder	NOUN
fnp-8974	91	7	is	be	AUX
fnp-8974	91	8	complex	complex	ADJ
fnp-8974	91	9	but	but	CCONJ
fnp-8974	91	10	consistently	consistently	ADV
fnp-8974	91	11	includes	include	VERB
fnp-8974	91	12	developmental	developmental	ADJ
fnp-8974	91	13	delay	delay	NOUN
fnp-8974	91	14	with	with	ADP
fnp-8974	91	15	intellectual	intellectual	ADJ
fnp-8974	91	16	disability	disability	NOUN
fnp-8974	91	17	,	,	PUNCT
fnp-8974	91	18	severe	severe	ADJ
fnp-8974	91	19	speech	speech	NOUN
fnp-8974	91	20	and	and	CCONJ
fnp-8974	91	21	varying	vary	VERB
fnp-8974	91	22	motor	motor	NOUN
fnp-8974	91	23	delay	delay	NOUN
fnp-8974	91	24	,	,	PUNCT
fnp-8974	91	25	autistic	autistic	ADJ
fnp-8974	91	26	behavioral	behavioral	ADJ
fnp-8974	91	27	abnormalities	abnormality	NOUN
fnp-8974	91	28	,	,	PUNCT
fnp-8974	91	29	disturbed	disturb	VERB
fnp-8974	91	30	sleep	sleep	NOUN
fnp-8974	91	31	patterns	pattern	NOUN
fnp-8974	91	32	,	,	PUNCT
fnp-8974	91	33	and	and	CCONJ
fnp-8974	91	34	epileptic	epileptic	ADJ
fnp-8974	91	35	seizures	seizure	NOUN
fnp-8974	91	36	.	.	PUNCT
fnp-8974	92	1	objective(s	objective(s	NOUN
fnp-8974	92	2	):	):	PUNCT
fnp-8974	92	3	explore	explore	VERB
fnp-8974	92	4	the	the	DET
fnp-8974	92	5	molecular	molecular	ADJ
fnp-8974	92	6	basis	basis	NOUN
fnp-8974	92	7	of	of	ADP
fnp-8974	92	8	neurological	neurological	ADJ
fnp-8974	92	9	deficits	deficit	NOUN
fnp-8974	92	10	in	in	ADP
fnp-8974	92	11	meis2	meis2	NOUN
fnp-8974	92	12	-	-	PUNCT
fnp-8974	92	13	related	relate	VERB
fnp-8974	92	14	syndrome	syndrome	NOUN
fnp-8974	92	15	use	use	VERB
fnp-8974	92	16	an	an	DET
fnp-8974	92	17	in	in	ADP
fnp-8974	92	18	vitro	vitro	X
fnp-8974	92	19	mesc	mesc	X
fnp-8974	92	20	neurogenic	neurogenic	ADJ
fnp-8974	92	21	differentiation	differentiation	NOUN
fnp-8974	92	22	model	model	NOUN
fnp-8974	92	23	to	to	PART
fnp-8974	92	24	mimic	mimic	VERB
fnp-8974	92	25	early	early	ADJ
fnp-8974	92	26	neurodevelopmental	neurodevelopmental	ADJ
fnp-8974	92	27	aspects	aspect	NOUN
fnp-8974	92	28	question(s	question(s	PROPN
fnp-8974	92	29	):	):	PUNCT
fnp-8974	92	30	which	which	PRON
fnp-8974	92	31	molecular	molecular	ADJ
fnp-8974	92	32	mechanisms	mechanism	NOUN
fnp-8974	92	33	drive	drive	VERB
fnp-8974	92	34	the	the	DET
fnp-8974	92	35	neurological	neurological	ADJ
fnp-8974	92	36	symptoms	symptom	NOUN
fnp-8974	92	37	of	of	ADP
fnp-8974	92	38	meis2	meis2	NOUN
fnp-8974	92	39	-	-	PUNCT
fnp-8974	92	40	related	relate	VERB
fnp-8974	92	41	syndrome	syndrome	NOUN
fnp-8974	92	42	?	?	PUNCT
fnp-8974	93	1	how	how	SCONJ
fnp-8974	93	2	well	well	ADV
fnp-8974	93	3	does	do	AUX
fnp-8974	93	4	mesc	mesc	NOUN
fnp-8974	93	5	neurogenic	neurogenic	ADJ
fnp-8974	93	6	differentiation	differentiation	NOUN
fnp-8974	93	7	recapitulate	recapitulate	VERB
fnp-8974	93	8	early	early	ADJ
fnp-8974	93	9	neural	neural	ADJ
fnp-8974	93	10	development	development	NOUN
fnp-8974	93	11	in	in	ADP
fnp-8974	93	12	this	this	DET
fnp-8974	93	13	syndrome	syndrome	NOUN
fnp-8974	93	14	?	?	PUNCT
fnp-8974	94	1	method(s	method(	VERB
fnp-8974	94	2	):	):	PUNCT
fnp-8974	94	3	mescs	mesc	NOUN
fnp-8974	94	4	with	with	ADP
fnp-8974	94	5	or	or	CCONJ
fnp-8974	94	6	without	without	ADP
fnp-8974	94	7	crispr	crispr	NOUN
fnp-8974	94	8	-	-	PUNCT
fnp-8974	94	9	generated	generate	VERB
fnp-8974	94	10	meis2	meis2	NOUN
fnp-8974	94	11	mutation	mutation	NOUN
fnp-8974	94	12	subjected	subject	VERB
fnp-8974	94	13	to	to	ADP
fnp-8974	94	14	neurogenic	neurogenic	ADJ
fnp-8974	94	15	-	-	ADJ
fnp-8974	94	16	gabaergic	gabaergic	ADJ
fnp-8974	94	17	differentiation	differentiation	NOUN
fnp-8974	94	18	chromatin	chromatin	NOUN
fnp-8974	94	19	immunoprecipitation	immunoprecipitation	NOUN
fnp-8974	94	20	and	and	CCONJ
fnp-8974	94	21	chip	chip	NOUN
fnp-8974	94	22	-	-	PUNCT
fnp-8974	94	23	seq	seq	NOUN
fnp-8974	94	24	for	for	ADP
fnp-8974	94	25	meis2	meis2	NOUN
fnp-8974	94	26	at	at	ADP
fnp-8974	94	27	early	early	ADJ
fnp-8974	94	28	differentiation	differentiation	NOUN
fnp-8974	94	29	stages	stage	VERB
fnp-8974	94	30	transcriptome	transcriptome	ADJ
fnp-8974	94	31	analysis	analysis	NOUN
fnp-8974	94	32	and	and	CCONJ
fnp-8974	94	33	qpcr	qpcr	ADV
fnp-8974	94	34	of	of	ADP
fnp-8974	94	35	differentiating	differentiate	VERB
fnp-8974	94	36	mescs	mesc	NOUN
fnp-8974	94	37	rna	rna	NOUN
fnp-8974	94	38	-	-	PUNCT
fnp-8974	94	39	sequencing	sequencing	NOUN
fnp-8974	94	40	of	of	ADP
fnp-8974	94	41	later	later	ADV
fnp-8974	94	42	neuronally	neuronally	ADV
fnp-8974	94	43	differentiated	differentiate	VERB
fnp-8974	94	44	mescs	mesc	NOUN
fnp-8974	94	45	luciferase	luciferase	VERB
fnp-8974	94	46	reporter	reporter	NOUN
fnp-8974	94	47	assays	assay	NOUN
fnp-8974	94	48	on	on	ADP
fnp-8974	94	49	meis2	meis2	NOUN
fnp-8974	94	50	-	-	PUNCT
fnp-8974	94	51	bound	bind	VERB
fnp-8974	94	52	genomic	genomic	NOUN
fnp-8974	94	53	regions	region	NOUN
fnp-8974	94	54	result(s	result(s	PROPN
fnp-8974	94	55	):	):	PUNCT
fnp-8974	94	56	at	at	ADP
fnp-8974	94	57	early	early	ADJ
fnp-8974	94	58	differentiation	differentiation	NOUN
fnp-8974	94	59	stages	stage	NOUN
fnp-8974	94	60	:	:	PUNCT
fnp-8974	94	61	identification	identification	NOUN
fnp-8974	94	62	of	of	ADP
fnp-8974	94	63	a	a	DET
fnp-8974	94	64	key	key	ADJ
fnp-8974	94	65	mammalian	mammalian	ADJ
fnp-8974	94	66	brain	brain	NOUN
fnp-8974	94	67	development	development	NOUN
fnp-8974	94	68	regulator	regulator	NOUN
fnp-8974	94	69	as	as	ADP
fnp-8974	94	70	a	a	DET
fnp-8974	94	71	direct	direct	ADJ
fnp-8974	94	72	meis2	meis2	NOUN
fnp-8974	94	73	target	target	NOUN
fnp-8974	94	74	meis2	meis2	ADV
fnp-8974	94	75	-	-	PUNCT
fnp-8974	94	76	bound	bind	VERB
fnp-8974	94	77	regions	region	NOUN
fnp-8974	94	78	function	function	VERB
fnp-8974	94	79	as	as	ADP
fnp-8974	94	80	transcriptional	transcriptional	ADJ
fnp-8974	94	81	enhancers	enhancer	NOUN
fnp-8974	94	82	in	in	ADP
fnp-8974	94	83	later	later	ADV
fnp-8974	94	84	neuronally	neuronally	ADV
fnp-8974	94	85	differentiated	differentiate	VERB
fnp-8974	94	86	mescs	mesc	NOUN
fnp-8974	94	87	:	:	PUNCT
fnp-8974	94	88	mutant	mutant	ADJ
fnp-8974	94	89	neurons	neuron	NOUN
fnp-8974	94	90	exhibit	exhibit	VERB
fnp-8974	94	91	aberrant	aberrant	ADJ
fnp-8974	94	92	expression	expression	NOUN
fnp-8974	94	93	of	of	ADP
fnp-8974	94	94	specific	specific	ADJ
fnp-8974	94	95	synaptic	synaptic	ADJ
fnp-8974	94	96	markers	marker	NOUN
fnp-8974	94	97	dysregulation	dysregulation	NOUN
fnp-8974	94	98	of	of	ADP
fnp-8974	94	99	genes	gene	NOUN
fnp-8974	94	100	involved	involve	VERB
fnp-8974	94	101	in	in	ADP
fnp-8974	94	102	neurotransmitter	neurotransmitter	NOUN
fnp-8974	94	103	metabolism	metabolism	NOUN
fnp-8974	94	104	and	and	CCONJ
fnp-8974	94	105	catabolism	catabolism	NOUN
fnp-8974	94	106	conclusion(s	conclusion(s	NOUN
fnp-8974	94	107	):	):	PUNCT
fnp-8974	94	108	collectively	collectively	ADV
fnp-8974	94	109	,	,	PUNCT
fnp-8974	94	110	these	these	DET
fnp-8974	94	111	results	result	NOUN
fnp-8974	94	112	provide	provide	VERB
fnp-8974	94	113	a	a	DET
fnp-8974	94	114	conceptional	conceptional	ADJ
fnp-8974	94	115	framework	framework	NOUN
fnp-8974	94	116	for	for	ADP
fnp-8974	94	117	understanding	understand	VERB
fnp-8974	94	118	the	the	DET
fnp-8974	94	119	neurological	neurological	ADJ
fnp-8974	94	120	deficits	deficit	NOUN
fnp-8974	94	121	seen	see	VERB
fnp-8974	94	122	in	in	ADP
fnp-8974	94	123	meis2	meis2	NOUN
fnp-8974	94	124	-	-	PUNCT
fnp-8974	94	125	related	relate	VERB
fnp-8974	94	126	syndrome	syndrome	NOUN
fnp-8974	94	127	patients	patient	NOUN
fnp-8974	94	128	and	and	CCONJ
fnp-8974	94	129	show	show	VERB
fnp-8974	94	130	an	an	DET
fnp-8974	94	131	unexpected	unexpected	ADJ
fnp-8974	94	132	link	link	NOUN
fnp-8974	94	133	between	between	ADP
fnp-8974	94	134	two	two	NUM
fnp-8974	94	135	neurodevelopmental	neurodevelopmental	ADJ
fnp-8974	94	136	disorders	disorder	NOUN
fnp-8974	94	137	previously	previously	ADV
fnp-8974	94	138	considered	consider	VERB
fnp-8974	94	139	to	to	PART
fnp-8974	94	140	be	be	AUX
fnp-8974	94	141	unrelated	unrelated	ADJ
fnp-8974	94	142	.	.	PUNCT
fnp-8974	95	1	p07	p07	PROPN
fnp-8974	95	2	free	free	ADJ
fnp-8974	95	3	neuropathol	neuropathol	NOUN
fnp-8974	96	1	6:17:16	6:17:16	NUM
fnp-8974	96	2	comparison	comparison	NOUN
fnp-8974	96	3	of	of	ADP
fnp-8974	96	4	neuroinflammatory	neuroinflammatory	ADJ
fnp-8974	96	5	cellular	cellular	ADJ
fnp-8974	96	6	composition	composition	NOUN
fnp-8974	96	7	of	of	ADP
fnp-8974	96	8	tumors	tumor	NOUN
fnp-8974	96	9	and	and	CCONJ
fnp-8974	96	10	peritumoral	peritumoral	ADJ
fnp-8974	96	11	tissue	tissue	NOUN
fnp-8974	96	12	in	in	ADP
fnp-8974	96	13	leat	leat	NOUN
fnp-8974	96	14	patients	patient	NOUN
fnp-8974	96	15	with	with	ADP
fnp-8974	96	16	and	and	CCONJ
fnp-8974	96	17	without	without	ADP
fnp-8974	96	18	post	post	ADJ
fnp-8974	96	19	-	-	ADJ
fnp-8974	96	20	surgical	surgical	ADJ
fnp-8974	96	21	persistence	persistence	NOUN
fnp-8974	96	22	of	of	ADP
fnp-8974	96	23	epilepsy	epilepsy	ADJ
fnp-8974	96	24	dorothea	dorothea	PROPN
fnp-8974	96	25	münch1	münch1	PROPN
fnp-8974	96	26	,	,	PUNCT
fnp-8974	96	27	ricardo	ricardo	PROPN
fnp-8974	96	28	kienitz2	kienitz2	PROPN
fnp-8974	96	29	,	,	PUNCT
fnp-8974	96	30	andrea	andrea	PROPN
fnp-8974	96	31	spyrantis3	spyrantis3	PROPN
fnp-8974	96	32	,	,	PUNCT
fnp-8974	96	33	jürgen	jürgen	PROPN
fnp-8974	96	34	konczalla3	konczalla3	PROPN
fnp-8974	96	35	,	,	PUNCT
fnp-8974	96	36	ida	ida	PROPN
fnp-8974	96	37	vogt4	vogt4	PROPN
fnp-8974	96	38	,	,	PUNCT
fnp-8974	96	39	pia	pia	PROPN
fnp-8974	96	40	s.	s.	PROPN
fnp-8974	96	41	zeiner4,5,6,7,8	zeiner4,5,6,7,8	PROPN
fnp-8974	96	42	,	,	PUNCT
fnp-8974	96	43	karl	karl	PROPN
fnp-8974	96	44	heinz	heinz	PROPN
fnp-8974	96	45	plate1,6,7,8	plate1,6,7,8	PROPN
fnp-8974	96	46	,	,	PUNCT
fnp-8974	96	47	felix	felix	PROPN
fnp-8974	96	48	rosenow2	rosenow2	PROPN
fnp-8974	96	49	,	,	PUNCT
fnp-8974	96	50	catrin	catrin	NOUN
fnp-8974	96	51	mann2	mann2	PROPN
fnp-8974	96	52	,	,	PUNCT
fnp-8974	96	53	katharina	katharina	PROPN
fnp-8974	96	54	j.	j.	PROPN
fnp-8974	96	55	weber1,6,7,8	weber1,6,7,8	PROPN
fnp-8974	96	56	1	1	NUM
fnp-8974	96	57	goethe	goethe	PROPN
fnp-8974	96	58	university	university	PROPN
fnp-8974	96	59	frankfurt	frankfurt	PROPN
fnp-8974	96	60	,	,	PUNCT
fnp-8974	96	61	university	university	NOUN
fnp-8974	96	62	hospital	hospital	NOUN
fnp-8974	96	63	,	,	PUNCT
fnp-8974	96	64	neurological	neurological	ADJ
fnp-8974	96	65	institute	institute	NOUN
fnp-8974	96	66	(	(	PUNCT
fnp-8974	96	67	edinger	edinger	PROPN
fnp-8974	96	68	institute	institute	PROPN
fnp-8974	96	69	)	)	PUNCT
fnp-8974	96	70	,	,	PUNCT
fnp-8974	96	71	frankfurt	frankfurt	PROPN
fnp-8974	96	72	am	be	AUX
fnp-8974	96	73	main	main	ADJ
fnp-8974	96	74	,	,	PUNCT
fnp-8974	96	75	germany	germany	PROPN
fnp-8974	96	76	2	2	NUM
fnp-8974	96	77	goethe	goethe	PROPN
fnp-8974	96	78	university	university	PROPN
fnp-8974	96	79	frankfurt	frankfurt	PROPN
fnp-8974	96	80	,	,	PUNCT
fnp-8974	96	81	epilepsy	epilepsy	NOUN
fnp-8974	96	82	center	center	NOUN
fnp-8974	96	83	frankfurt	frankfurt	PROPN
fnp-8974	96	84	rhine	rhine	PROPN
fnp-8974	96	85	-	-	PUNCT
fnp-8974	96	86	main	main	ADJ
fnp-8974	96	87	,	,	PUNCT
fnp-8974	96	88	department	department	NOUN
fnp-8974	96	89	for	for	ADP
fnp-8974	96	90	neurology	neurology	NOUN
fnp-8974	96	91	,	,	PUNCT
fnp-8974	96	92	university	university	NOUN
fnp-8974	96	93	medical	medical	ADJ
fnp-8974	96	94	center	center	PROPN
fnp-8974	96	95	frankfurt	frankfurt	PROPN
fnp-8974	96	96	,	,	PUNCT
fnp-8974	96	97	frankfurt	frankfurt	PROPN
fnp-8974	96	98	am	be	AUX
fnp-8974	96	99	main	main	ADJ
fnp-8974	96	100	,	,	PUNCT
fnp-8974	96	101	germany	germany	PROPN
fnp-8974	96	102	3	3	NUM
fnp-8974	96	103	goethe	goethe	PROPN
fnp-8974	96	104	university	university	PROPN
fnp-8974	96	105	frankfurt	frankfurt	PROPN
fnp-8974	96	106	,	,	PUNCT
fnp-8974	96	107	department	department	NOUN
fnp-8974	96	108	of	of	ADP
fnp-8974	96	109	neurosurgery	neurosurgery	NOUN
fnp-8974	96	110	,	,	PUNCT
fnp-8974	96	111	center	center	NOUN
fnp-8974	96	112	of	of	ADP
fnp-8974	96	113	neurology	neurology	NOUN
fnp-8974	96	114	and	and	CCONJ
fnp-8974	96	115	neurosurgery	neurosurgery	NOUN
fnp-8974	96	116	,	,	PUNCT
fnp-8974	96	117	frankfurt	frankfurt	PROPN
fnp-8974	96	118	am	be	AUX
fnp-8974	96	119	main	main	ADJ
fnp-8974	96	120	,	,	PUNCT
fnp-8974	96	121	germany	germany	PROPN
fnp-8974	96	122	4	4	NUM
fnp-8974	96	123	goethe	goethe	PROPN
fnp-8974	96	124	university	university	PROPN
fnp-8974	96	125	frankfurt	frankfurt	PROPN
fnp-8974	96	126	,	,	PUNCT
fnp-8974	96	127	university	university	NOUN
fnp-8974	96	128	hospital	hospital	NOUN
fnp-8974	96	129	,	,	PUNCT
fnp-8974	96	130	dr	dr	PROPN
fnp-8974	96	131	.	.	PROPN
fnp-8974	96	132	senckenberg	senckenberg	PROPN
fnp-8974	96	133	institute	institute	PROPN
fnp-8974	96	134	of	of	ADP
fnp-8974	96	135	neurooncology	neurooncology	PROPN
fnp-8974	96	136	,	,	PUNCT
fnp-8974	96	137	germany	germany	PROPN
fnp-8974	96	138	,	,	PUNCT
fnp-8974	96	139	frankfurt	frankfurt	PROPN
fnp-8974	96	140	am	be	AUX
fnp-8974	96	141	main	main	ADJ
fnp-8974	96	142	,	,	PUNCT
fnp-8974	96	143	germany	germany	PROPN
fnp-8974	96	144	5	5	NUM
fnp-8974	96	145	goethe	goethe	PROPN
fnp-8974	96	146	university	university	PROPN
fnp-8974	96	147	frankfurt	frankfurt	PROPN
fnp-8974	96	148	,	,	PUNCT
fnp-8974	96	149	university	university	NOUN
fnp-8974	96	150	hospital	hospital	NOUN
fnp-8974	96	151	,	,	PUNCT
fnp-8974	96	152	department	department	NOUN
fnp-8974	96	153	of	of	ADP
fnp-8974	96	154	neurology	neurology	NOUN
fnp-8974	96	155	,	,	PUNCT
fnp-8974	96	156	frankfurt	frankfurt	PROPN
fnp-8974	96	157	am	be	AUX
fnp-8974	96	158	main	main	ADJ
fnp-8974	96	159	,	,	PUNCT
fnp-8974	96	160	germany	germany	PROPN
fnp-8974	96	161	6	6	NUM
fnp-8974	96	162	goethe	goethe	PROPN
fnp-8974	96	163	university	university	PROPN
fnp-8974	96	164	frankfurt	frankfurt	PROPN
fnp-8974	96	165	,	,	PUNCT
fnp-8974	96	166	frankfurt	frankfurt	PROPN
fnp-8974	96	167	cancer	cancer	PROPN
fnp-8974	96	168	institute	institute	PROPN
fnp-8974	96	169	(	(	PUNCT
fnp-8974	96	170	fci	fci	PROPN
fnp-8974	96	171	)	)	PUNCT
fnp-8974	96	172	,	,	PUNCT
fnp-8974	96	173	frankfurt	frankfurt	PROPN
fnp-8974	96	174	am	be	AUX
fnp-8974	96	175	main	main	ADJ
fnp-8974	96	176	,	,	PUNCT
fnp-8974	96	177	germany	germany	PROPN
fnp-8974	96	178	7	7	NUM
fnp-8974	96	179	german	german	ADJ
fnp-8974	96	180	cancer	cancer	NOUN
fnp-8974	96	181	consortium	consortium	NOUN
fnp-8974	96	182	(	(	PUNCT
fnp-8974	96	183	dktk	dktk	NOUN
fnp-8974	96	184	)	)	PUNCT
fnp-8974	96	185	,	,	PUNCT
fnp-8974	96	186	partner	partner	NOUN
fnp-8974	96	187	site	site	NOUN
fnp-8974	96	188	frankfurt	frankfurt	PROPN
fnp-8974	96	189	,	,	PUNCT
fnp-8974	96	190	and	and	CCONJ
fnp-8974	96	191	german	german	ADJ
fnp-8974	96	192	cancer	cancer	NOUN
fnp-8974	96	193	research	research	NOUN
fnp-8974	96	194	center	center	NOUN
fnp-8974	96	195	(	(	PUNCT
fnp-8974	96	196	dkfz	dkfz	PROPN
fnp-8974	96	197	)	)	PUNCT
fnp-8974	96	198	,	,	PUNCT
fnp-8974	96	199	heidelberg	heidelberg	PROPN
fnp-8974	96	200	,	,	PUNCT
fnp-8974	96	201	germany	germany	PROPN
fnp-8974	96	202	8	8	NUM
fnp-8974	96	203	goethe	goethe	PROPN
fnp-8974	96	204	university	university	PROPN
fnp-8974	96	205	frankfurt	frankfurt	PROPN
fnp-8974	96	206	,	,	PUNCT
fnp-8974	96	207	university	university	NOUN
fnp-8974	96	208	hospital	hospital	NOUN
fnp-8974	96	209	,	,	PUNCT
fnp-8974	96	210	university	university	NOUN
fnp-8974	96	211	cancer	cancer	NOUN
fnp-8974	96	212	center	center	NOUN
fnp-8974	96	213	(	(	PUNCT
fnp-8974	96	214	uct	uct	PROPN
fnp-8974	96	215	)	)	PUNCT
fnp-8974	96	216	,	,	PUNCT
fnp-8974	96	217	frankfurt	frankfurt	PROPN
fnp-8974	96	218	am	be	AUX
fnp-8974	96	219	main	main	ADJ
fnp-8974	96	220	,	,	PUNCT
fnp-8974	96	221	germany	germany	PROPN
fnp-8974	96	222	background	background	NOUN
fnp-8974	96	223	:	:	PUNCT
fnp-8974	96	224	low	low	ADJ
fnp-8974	96	225	-	-	PUNCT
fnp-8974	96	226	grade	grade	NOUN
fnp-8974	96	227	epilepsy	epilepsy	NOUN
fnp-8974	96	228	-	-	PUNCT
fnp-8974	96	229	associated	associate	VERB
fnp-8974	96	230	tumors	tumor	NOUN
fnp-8974	96	231	(	(	PUNCT
fnp-8974	96	232	leat	leat	NOUN
fnp-8974	96	233	)	)	PUNCT
fnp-8974	96	234	are	be	AUX
fnp-8974	96	235	primary	primary	ADJ
fnp-8974	96	236	brain	brain	NOUN
fnp-8974	96	237	tumours	tumours	NOUN
fnp-8974	96	238	,	,	PUNCT
fnp-8974	96	239	usually	usually	ADV
fnp-8974	96	240	classified	classify	VERB
fnp-8974	96	241	as	as	ADP
fnp-8974	96	242	cns	cns	PROPN
fnp-8974	96	243	who	who	PRON
fnp-8974	96	244	grade	grade	VERB
fnp-8974	96	245	1	1	NUM
fnp-8974	96	246	lesions	lesion	NOUN
fnp-8974	96	247	.	.	PUNCT
fnp-8974	97	1	leats	leat	NOUN
fnp-8974	97	2	are	be	AUX
fnp-8974	97	3	clinically	clinically	ADV
fnp-8974	97	4	associated	associate	VERB
fnp-8974	97	5	with	with	ADP
fnp-8974	97	6	drug	drug	NOUN
fnp-8974	97	7	-	-	PUNCT
fnp-8974	97	8	resistant	resistant	ADJ
fnp-8974	97	9	epilepsy	epilepsy	NOUN
fnp-8974	97	10	.	.	PUNCT
fnp-8974	98	1	early	early	ADJ
fnp-8974	98	2	epilepsy	epilepsy	NOUN
fnp-8974	98	3	surgery	surgery	NOUN
fnp-8974	98	4	is	be	AUX
fnp-8974	98	5	recommended	recommend	VERB
fnp-8974	98	6	in	in	ADP
fnp-8974	98	7	pharmacorefractory	pharmacorefractory	ADJ
fnp-8974	98	8	patients	patient	NOUN
fnp-8974	98	9	.	.	PUNCT
fnp-8974	99	1	given	give	VERB
fnp-8974	99	2	that	that	SCONJ
fnp-8974	99	3	surgical	surgical	ADJ
fnp-8974	99	4	outcomes	outcome	NOUN
fnp-8974	99	5	improve	improve	VERB
fnp-8974	99	6	significantly	significantly	ADV
fnp-8974	99	7	when	when	SCONJ
fnp-8974	99	8	both	both	CCONJ
fnp-8974	99	9	the	the	DET
fnp-8974	99	10	tumor	tumor	NOUN
fnp-8974	99	11	is	be	AUX
fnp-8974	99	12	excised	excise	VERB
fnp-8974	99	13	early	early	ADV
fnp-8974	99	14	in	in	ADP
fnp-8974	99	15	the	the	DET
fnp-8974	99	16	disease	disease	NOUN
fnp-8974	99	17	course	course	NOUN
fnp-8974	99	18	,	,	PUNCT
fnp-8974	99	19	and	and	CCONJ
fnp-8974	99	20	adjacent	adjacent	ADJ
fnp-8974	99	21	epileptogenic	epileptogenic	ADJ
fnp-8974	99	22	tissue	tissue	NOUN
fnp-8974	99	23	is	be	AUX
fnp-8974	99	24	removed	remove	VERB
fnp-8974	99	25	,	,	PUNCT
fnp-8974	99	26	it	it	PRON
fnp-8974	99	27	is	be	AUX
fnp-8974	99	28	assumed	assume	VERB
fnp-8974	99	29	the	the	DET
fnp-8974	99	30	perilesional	perilesional	ADJ
fnp-8974	99	31	tissue	tissue	NOUN
fnp-8974	99	32	alterations	alteration	NOUN
fnp-8974	99	33	play	play	VERB
fnp-8974	99	34	a	a	DET
fnp-8974	99	35	vital	vital	ADJ
fnp-8974	99	36	role	role	NOUN
fnp-8974	99	37	in	in	ADP
fnp-8974	99	38	the	the	DET
fnp-8974	99	39	establishment	establishment	NOUN
fnp-8974	99	40	of	of	ADP
fnp-8974	99	41	a	a	DET
fnp-8974	99	42	pro	pro	ADJ
fnp-8974	99	43	-	-	ADJ
fnp-8974	99	44	convulsive	convulsive	ADJ
fnp-8974	99	45	environment	environment	NOUN
fnp-8974	99	46	.	.	PUNCT
fnp-8974	100	1	aim	aim	VERB
fnp-8974	100	2	:	:	PUNCT
fnp-8974	100	3	this	this	DET
fnp-8974	100	4	study	study	NOUN
fnp-8974	100	5	aims	aim	VERB
fnp-8974	100	6	to	to	PART
fnp-8974	100	7	investigate	investigate	VERB
fnp-8974	100	8	the	the	DET
fnp-8974	100	9	cellular	cellular	ADJ
fnp-8974	100	10	composition	composition	NOUN
fnp-8974	100	11	of	of	ADP
fnp-8974	100	12	leat	leat	NOUN
fnp-8974	100	13	and	and	CCONJ
fnp-8974	100	14	peritumoral	peritumoral	ADJ
fnp-8974	100	15	tissue	tissue	NOUN
fnp-8974	100	16	with	with	ADP
fnp-8974	100	17	a	a	DET
fnp-8974	100	18	focus	focus	NOUN
fnp-8974	100	19	on	on	ADP
fnp-8974	100	20	the	the	DET
fnp-8974	100	21	peritumoral	peritumoral	ADJ
fnp-8974	100	22	zone	zone	NOUN
fnp-8974	100	23	and	and	CCONJ
fnp-8974	100	24	its	its	PRON
fnp-8974	100	25	potential	potential	ADJ
fnp-8974	100	26	epileptogenic	epileptogenic	ADJ
fnp-8974	100	27	role	role	NOUN
fnp-8974	100	28	.	.	PUNCT
fnp-8974	101	1	methods	method	NOUN
fnp-8974	101	2	:	:	PUNCT
fnp-8974	101	3	27	27	NUM
fnp-8974	101	4	leat	leat	NOUN
fnp-8974	101	5	patients	patient	NOUN
fnp-8974	101	6	were	be	AUX
fnp-8974	101	7	included	include	VERB
fnp-8974	101	8	.	.	PUNCT
fnp-8974	102	1	in	in	ADP
fnp-8974	102	2	each	each	DET
fnp-8974	102	3	patient	patient	NOUN
fnp-8974	102	4	the	the	DET
fnp-8974	102	5	cellular	cellular	ADJ
fnp-8974	102	6	composition	composition	NOUN
fnp-8974	102	7	of	of	ADP
fnp-8974	102	8	the	the	DET
fnp-8974	102	9	vital	vital	ADJ
fnp-8974	102	10	tumor	tumor	NOUN
fnp-8974	102	11	and	and	CCONJ
fnp-8974	102	12	adjacent	adjacent	ADJ
fnp-8974	102	13	tissue	tissue	NOUN
fnp-8974	102	14	were	be	AUX
fnp-8974	102	15	analysed	analyse	VERB
fnp-8974	102	16	.	.	PUNCT
fnp-8974	103	1	adaptive	adaptive	ADJ
fnp-8974	103	2	and	and	CCONJ
fnp-8974	103	3	myeloid	myeloid	ADJ
fnp-8974	103	4	immune	immune	ADJ
fnp-8974	103	5	cells	cell	NOUN
fnp-8974	103	6	,	,	PUNCT
fnp-8974	103	7	astrocytes	astrocyte	NOUN
fnp-8974	103	8	and	and	CCONJ
fnp-8974	103	9	neurons	neuron	NOUN
fnp-8974	103	10	were	be	AUX
fnp-8974	103	11	analysed	analyse	VERB
fnp-8974	103	12	by	by	ADP
fnp-8974	103	13	immunohistochemistry	immunohistochemistry	NOUN
fnp-8974	103	14	and	and	CCONJ
fnp-8974	103	15	assessed	assess	VERB
fnp-8974	103	16	semi	semi	ADV
fnp-8974	103	17	-	-	ADJ
fnp-8974	103	18	quantitatively	quantitatively	ADV
fnp-8974	103	19	using	use	VERB
fnp-8974	103	20	an	an	DET
fnp-8974	103	21	image	image	NOUN
fnp-8974	103	22	analysis	analysis	NOUN
fnp-8974	103	23	software	software	NOUN
fnp-8974	103	24	.	.	PUNCT
fnp-8974	104	1	epigenetic	epigenetic	ADJ
fnp-8974	104	2	alterations	alteration	NOUN
fnp-8974	104	3	potentially	potentially	ADV
fnp-8974	104	4	contributing	contribute	VERB
fnp-8974	104	5	to	to	ADP
fnp-8974	104	6	epileptogenesis	epileptogenesis	NOUN
fnp-8974	104	7	were	be	AUX
fnp-8974	104	8	examined	examine	VERB
fnp-8974	104	9	in	in	ADP
fnp-8974	104	10	five	five	NUM
fnp-8974	104	11	representative	representative	ADJ
fnp-8974	104	12	tumors	tumor	NOUN
fnp-8974	104	13	.	.	PUNCT
fnp-8974	105	1	the	the	DET
fnp-8974	105	2	results	result	NOUN
fnp-8974	105	3	were	be	AUX
fnp-8974	105	4	correlated	correlate	VERB
fnp-8974	105	5	with	with	ADP
fnp-8974	105	6	clinical	clinical	ADJ
fnp-8974	105	7	parameters	parameter	NOUN
fnp-8974	105	8	.	.	PUNCT
fnp-8974	106	1	results	result	NOUN
fnp-8974	106	2	:	:	PUNCT
fnp-8974	106	3	our	our	PRON
fnp-8974	106	4	preliminary	preliminary	ADJ
fnp-8974	106	5	results	result	NOUN
fnp-8974	106	6	from	from	ADP
fnp-8974	106	7	the	the	DET
fnp-8974	106	8	immunohistochemical	immunohistochemical	ADJ
fnp-8974	106	9	staining	staining	NOUN
fnp-8974	106	10	show	show	NOUN
fnp-8974	106	11	that	that	SCONJ
fnp-8974	106	12	the	the	DET
fnp-8974	106	13	highest	high	ADJ
fnp-8974	106	14	levels	level	NOUN
fnp-8974	106	15	of	of	ADP
fnp-8974	106	16	lymphocytes	lymphocyte	NOUN
fnp-8974	106	17	,	,	PUNCT
fnp-8974	106	18	macrophages	macrophage	NOUN
fnp-8974	106	19	and	and	CCONJ
fnp-8974	106	20	microglia	microglia	NOUN
fnp-8974	106	21	were	be	AUX
fnp-8974	106	22	found	find	VERB
fnp-8974	106	23	in	in	ADP
fnp-8974	106	24	the	the	DET
fnp-8974	106	25	tumors	tumor	NOUN
fnp-8974	106	26	.	.	PUNCT
fnp-8974	107	1	the	the	DET
fnp-8974	107	2	peritumoral	peritumoral	PROPN
fnp-8974	107	3	zone	zone	NOUN
fnp-8974	107	4	showed	show	VERB
fnp-8974	107	5	increased	increase	VERB
fnp-8974	107	6	levels	level	NOUN
fnp-8974	107	7	in	in	ADP
fnp-8974	107	8	comparison	comparison	NOUN
fnp-8974	107	9	with	with	ADP
fnp-8974	107	10	distant	distant	ADJ
fnp-8974	107	11	tissue	tissue	NOUN
fnp-8974	107	12	.	.	PUNCT
fnp-8974	108	1	additionally	additionally	ADV
fnp-8974	108	2	,	,	PUNCT
fnp-8974	108	3	we	we	PRON
fnp-8974	108	4	found	find	VERB
fnp-8974	108	5	correlations	correlation	NOUN
fnp-8974	108	6	between	between	ADP
fnp-8974	108	7	increased	increase	VERB
fnp-8974	108	8	levels	level	NOUN
fnp-8974	108	9	of	of	ADP
fnp-8974	108	10	immune	immune	ADJ
fnp-8974	108	11	cell	cell	NOUN
fnp-8974	108	12	infiltration	infiltration	NOUN
fnp-8974	108	13	and	and	CCONJ
fnp-8974	108	14	a	a	DET
fnp-8974	108	15	longer	long	ADJ
fnp-8974	108	16	duration	duration	NOUN
fnp-8974	108	17	of	of	ADP
fnp-8974	108	18	epilepsy	epilepsy	PROPN
fnp-8974	108	19	.	.	PUNCT
fnp-8974	109	1	conclusion	conclusion	NOUN
fnp-8974	109	2	:	:	PUNCT
fnp-8974	109	3	the	the	DET
fnp-8974	109	4	peritumoral	peritumoral	ADJ
fnp-8974	109	5	zone	zone	NOUN
fnp-8974	109	6	constitutes	constitute	VERB
fnp-8974	109	7	a	a	DET
fnp-8974	109	8	distinct	distinct	ADJ
fnp-8974	109	9	microenvironment	microenvironment	NOUN
fnp-8974	109	10	,	,	PUNCT
fnp-8974	109	11	displaying	display	VERB
fnp-8974	109	12	characteristic	characteristic	ADJ
fnp-8974	109	13	neuroinflammatory	neuroinflammatory	ADJ
fnp-8974	109	14	alterations	alteration	NOUN
fnp-8974	109	15	that	that	PRON
fnp-8974	109	16	differentiate	differentiate	VERB
fnp-8974	109	17	it	it	PRON
fnp-8974	109	18	from	from	ADP
fnp-8974	109	19	both	both	CCONJ
fnp-8974	109	20	the	the	DET
fnp-8974	109	21	tumor	tumor	NOUN
fnp-8974	109	22	and	and	CCONJ
fnp-8974	109	23	the	the	DET
fnp-8974	109	24	more	more	ADV
fnp-8974	109	25	distant	distant	ADJ
fnp-8974	109	26	surrounding	surround	VERB
fnp-8974	109	27	tissue	tissue	NOUN
fnp-8974	109	28	.	.	PUNCT
fnp-8974	110	1	these	these	DET
fnp-8974	110	2	alterations	alteration	NOUN
fnp-8974	110	3	may	may	AUX
fnp-8974	110	4	result	result	VERB
fnp-8974	110	5	from	from	ADP
fnp-8974	110	6	seizures	seizure	NOUN
fnp-8974	110	7	but	but	CCONJ
fnp-8974	110	8	could	could	AUX
fnp-8974	110	9	also	also	ADV
fnp-8974	110	10	contribute	contribute	VERB
fnp-8974	110	11	to	to	ADP
fnp-8974	110	12	the	the	DET
fnp-8974	110	13	progression	progression	NOUN
fnp-8974	110	14	of	of	ADP
fnp-8974	110	15	epileptogenesis	epileptogenesis	NOUN
fnp-8974	110	16	.	.	PUNCT
fnp-8974	111	1	iv	iv	X
fnp-8974	111	2	.	.	PROPN
fnp-8974	111	3	muscle	muscle	PROPN
fnp-8974	111	4	&	&	CCONJ
fnp-8974	111	5	nerve	nerve	PROPN
fnp-8974	111	6	p08	p08	PROPN
fnp-8974	111	7	free	free	ADJ
fnp-8974	111	8	neuropathol	neuropathol	NOUN
fnp-8974	111	9	6:17:18	6:17:18	NUM
fnp-8974	111	10	diagnosis	diagnosis	NOUN
fnp-8974	111	11	of	of	ADP
fnp-8974	111	12	immune	immune	NOUN
fnp-8974	111	13	-	-	PUNCT
fnp-8974	111	14	mediated	mediate	VERB
fnp-8974	111	15	myopathies	myopathy	NOUN
fnp-8974	111	16	on	on	ADP
fnp-8974	111	17	formalin	formalin	NOUN
fnp-8974	111	18	-	-	PUNCT
fnp-8974	111	19	fixed	fix	VERB
fnp-8974	111	20	,	,	PUNCT
fnp-8974	111	21	paraffin	paraffin	NOUN
fnp-8974	111	22	-	-	PUNCT
fnp-8974	111	23	embedded	embed	VERB
fnp-8974	111	24	muscle	muscle	NOUN
fnp-8974	111	25	tissue	tissue	NOUN
fnp-8974	111	26	samples	sample	NOUN
fnp-8974	111	27	anna	anna	PROPN
fnp-8974	111	28	brunn1	brunn1	PROPN
fnp-8974	111	29	,	,	PUNCT
fnp-8974	111	30	selin	selin	PROPN
fnp-8974	111	31	kanarya1	kanarya1	PROPN
fnp-8974	111	32	,	,	PUNCT
fnp-8974	111	33	wolfgang	wolfgang	PROPN
fnp-8974	111	34	merkt2	merkt2	PROPN
fnp-8974	111	35	1	1	NUM
fnp-8974	111	36	institute	institute	PROPN
fnp-8974	111	37	of	of	ADP
fnp-8974	111	38	neuropathology	neuropathology	NOUN
fnp-8974	111	39	,	,	PUNCT
fnp-8974	111	40	university	university	NOUN
fnp-8974	111	41	hospital	hospital	NOUN
fnp-8974	111	42	düsseldorf	düsseldorf	PROPN
fnp-8974	111	43	and	and	CCONJ
fnp-8974	111	44	medical	medical	ADJ
fnp-8974	111	45	faculty	faculty	NOUN
fnp-8974	111	46	,	,	PUNCT
fnp-8974	111	47	heinrich	heinrich	PROPN
fnp-8974	111	48	heine	heine	PROPN
fnp-8974	111	49	university	university	PROPN
fnp-8974	111	50	,	,	PUNCT
fnp-8974	111	51	düsseldorf	düsseldorf	PROPN
fnp-8974	111	52	,	,	PUNCT
fnp-8974	111	53	germany	germany	PROPN
fnp-8974	111	54	2	2	NUM
fnp-8974	111	55	department	department	NOUN
fnp-8974	111	56	of	of	ADP
fnp-8974	111	57	rheumatology	rheumatology	NOUN
fnp-8974	111	58	,	,	PUNCT
fnp-8974	111	59	university	university	NOUN
fnp-8974	111	60	hospital	hospital	NOUN
fnp-8974	111	61	düsseldorf	düsseldorf	PROPN
fnp-8974	111	62	,	,	PUNCT
fnp-8974	111	63	heinrich	heinrich	PROPN
fnp-8974	111	64	heine	heine	PROPN
fnp-8974	111	65	university	university	PROPN
fnp-8974	111	66	,	,	PUNCT
fnp-8974	111	67	düsseldorf	düsseldorf	PROPN
fnp-8974	111	68	,	,	PUNCT
fnp-8974	111	69	germany	germany	PROPN
fnp-8974	111	70	background	background	NOUN
fnp-8974	111	71	:	:	PUNCT
fnp-8974	111	72	immune	immune	NOUN
fnp-8974	111	73	-	-	PUNCT
fnp-8974	111	74	mediated	mediate	VERB
fnp-8974	111	75	myopathies	myopathy	NOUN
fnp-8974	111	76	(	(	PUNCT
fnp-8974	111	77	imm	imm	NOUN
fnp-8974	111	78	)	)	PUNCT
fnp-8974	111	79	are	be	AUX
fnp-8974	111	80	the	the	DET
fnp-8974	111	81	most	most	ADV
fnp-8974	111	82	common	common	ADJ
fnp-8974	111	83	indication	indication	NOUN
fnp-8974	111	84	for	for	ADP
fnp-8974	111	85	a	a	DET
fnp-8974	111	86	muscle	muscle	NOUN
fnp-8974	111	87	biopsy	biopsy	NOUN
fnp-8974	111	88	.	.	PUNCT
fnp-8974	112	1	according	accord	VERB
fnp-8974	112	2	to	to	ADP
fnp-8974	112	3	the	the	DET
fnp-8974	112	4	guidelines	guideline	NOUN
fnp-8974	112	5	for	for	ADP
fnp-8974	112	6	processing	processing	NOUN
fnp-8974	112	7	muscle	muscle	NOUN
fnp-8974	112	8	biopsies	biopsy	NOUN
fnp-8974	112	9	,	,	PUNCT
fnp-8974	112	10	cryopreserved	cryopreserve	VERB
fnp-8974	112	11	tissue	tissue	NOUN
fnp-8974	112	12	is	be	AUX
fnp-8974	112	13	required	require	VERB
fnp-8974	112	14	for	for	ADP
fnp-8974	112	15	immunohistochemistry	immunohistochemistry	NOUN
fnp-8974	112	16	of	of	ADP
fnp-8974	112	17	the	the	DET
fnp-8974	112	18	canonical	canonical	ADJ
fnp-8974	112	19	hla	hla	PROPN
fnp-8974	112	20	-	-	PUNCT
fnp-8974	112	21	abc	abc	PROPN
fnp-8974	112	22	molecule	molecule	NOUN
fnp-8974	112	23	of	of	ADP
fnp-8974	112	24	the	the	DET
fnp-8974	112	25	major	major	ADJ
fnp-8974	112	26	histocompatibility	histocompatibility	NOUN
fnp-8974	112	27	-	-	PUNCT
fnp-8974	112	28	complex	complex	ADJ
fnp-8974	112	29	(	(	PUNCT
fnp-8974	112	30	mhc	mhc	PROPN
fnp-8974	112	31	)	)	PUNCT
fnp-8974	112	32	class	class	NOUN
fnp-8974	112	33	i	i	PROPN
fnp-8974	112	34	,	,	PUNCT
fnp-8974	112	35	the	the	DET
fnp-8974	112	36	well	well	ADV
fnp-8974	112	37	-	-	PUNCT
fnp-8974	112	38	established	establish	VERB
fnp-8974	112	39	biomarker	biomarker	NOUN
fnp-8974	112	40	of	of	ADP
fnp-8974	112	41	imm	imm	NOUN
fnp-8974	112	42	.	.	PUNCT
fnp-8974	113	1	objective	objective	NOUN
fnp-8974	113	2	:	:	PUNCT
fnp-8974	114	1	muscle	muscle	NOUN
fnp-8974	114	2	biopsies	biopsy	NOUN
fnp-8974	114	3	with	with	ADP
fnp-8974	114	4	suspected	suspect	VERB
fnp-8974	114	5	imm	imm	NOUN
fnp-8974	114	6	are	be	AUX
fnp-8974	114	7	occasionally	occasionally	ADV
fnp-8974	114	8	submitted	submit	VERB
fnp-8974	114	9	as	as	ADP
fnp-8974	114	10	formalin	formalin	NOUN
fnp-8974	114	11	-	-	PUNCT
fnp-8974	114	12	fixed	fix	VERB
fnp-8974	114	13	and	and	CCONJ
fnp-8974	114	14	paraffin	paraffin	NOUN
fnp-8974	114	15	-	-	PUNCT
fnp-8974	114	16	embedded	embed	VERB
fnp-8974	114	17	(	(	PUNCT
fnp-8974	114	18	ffpe	ffpe	NOUN
fnp-8974	114	19	)	)	PUNCT
fnp-8974	114	20	specimen	speciman	NOUN
fnp-8974	114	21	,	,	PUNCT
fnp-8974	114	22	in	in	ADP
fnp-8974	114	23	which	which	PRON
fnp-8974	114	24	mhc	mhc	PROPN
fnp-8974	114	25	-	-	PUNCT
fnp-8974	114	26	i	i	PRON
fnp-8974	114	27	testing	testing	NOUN
fnp-8974	114	28	is	be	AUX
fnp-8974	114	29	less	less	ADV
fnp-8974	114	30	accurate	accurate	ADJ
fnp-8974	114	31	.	.	PUNCT
fnp-8974	115	1	question	question	NOUN
fnp-8974	115	2	:	:	PUNCT
fnp-8974	115	3	we	we	PRON
fnp-8974	115	4	tested	test	VERB
fnp-8974	115	5	the	the	DET
fnp-8974	115	6	hypothesis	hypothesis	NOUN
fnp-8974	115	7	that	that	PRON
fnp-8974	115	8	an	an	DET
fnp-8974	115	9	antibody	antibody	NOUN
fnp-8974	115	10	targeting	target	VERB
fnp-8974	115	11	the	the	DET
fnp-8974	115	12	non	non	ADJ
fnp-8974	115	13	-	-	ADJ
fnp-8974	115	14	canonical	canonical	ADJ
fnp-8974	115	15	mhc	mhc	PROPN
fnp-8974	115	16	-	-	PUNCT
fnp-8974	115	17	i	i	PROPN
fnp-8974	115	18	molecule	molecule	PROPN
fnp-8974	115	19	hla	hla	PROPN
fnp-8974	115	20	-	-	PUNCT
fnp-8974	115	21	e	e	NOUN
fnp-8974	115	22	may	may	AUX
fnp-8974	115	23	overcome	overcome	VERB
fnp-8974	115	24	this	this	DET
fnp-8974	115	25	limitation	limitation	NOUN
fnp-8974	115	26	and	and	CCONJ
fnp-8974	115	27	can	can	AUX
fnp-8974	115	28	be	be	AUX
fnp-8974	115	29	used	use	VERB
fnp-8974	115	30	on	on	ADP
fnp-8974	115	31	cryoand	cryoand	PROPN
fnp-8974	115	32	ffpe	ffpe	PROPN
fnp-8974	115	33	tissue	tissue	NOUN
fnp-8974	115	34	.	.	PUNCT
fnp-8974	116	1	method	method	NOUN
fnp-8974	116	2	:	:	PUNCT
fnp-8974	116	3	we	we	PRON
fnp-8974	116	4	examined	examine	VERB
fnp-8974	116	5	hla	hla	PROPN
fnp-8974	116	6	-	-	PUNCT
fnp-8974	116	7	e	e	NOUN
fnp-8974	116	8	expression	expression	NOUN
fnp-8974	116	9	on	on	ADP
fnp-8974	116	10	fifty	fifty	NUM
fnp-8974	116	11	frozen	frozen	ADJ
fnp-8974	116	12	muscle	muscle	NOUN
fnp-8974	116	13	biopsies	biopsy	NOUN
fnp-8974	116	14	,	,	PUNCT
fnp-8974	116	15	clinically	clinically	ADV
fnp-8974	116	16	and	and	CCONJ
fnp-8974	116	17	histologically	histologically	ADV
fnp-8974	116	18	diagnosed	diagnose	VERB
fnp-8974	116	19	as	as	ADP
fnp-8974	116	20	imm	imm	NOUN
fnp-8974	116	21	,	,	PUNCT
fnp-8974	116	22	and	and	CCONJ
fnp-8974	116	23	ten	ten	NUM
fnp-8974	116	24	frozen	frozen	ADJ
fnp-8974	116	25	samples	sample	NOUN
fnp-8974	116	26	with	with	ADP
fnp-8974	116	27	morphological	morphological	ADJ
fnp-8974	116	28	hallmarks	hallmark	NOUN
fnp-8974	116	29	of	of	ADP
fnp-8974	116	30	neurogenic	neurogenic	ADJ
fnp-8974	116	31	muscular	muscular	ADJ
fnp-8974	116	32	atrophy	atrophy	NOUN
fnp-8974	116	33	without	without	ADP
fnp-8974	116	34	signs	sign	NOUN
fnp-8974	116	35	of	of	ADP
fnp-8974	116	36	inflammation	inflammation	NOUN
fnp-8974	116	37	.	.	PUNCT
fnp-8974	117	1	subsequently	subsequently	ADV
fnp-8974	117	2	,	,	PUNCT
fnp-8974	117	3	we	we	PRON
fnp-8974	117	4	tested	test	VERB
fnp-8974	117	5	the	the	DET
fnp-8974	117	6	same	same	ADJ
fnp-8974	117	7	hla	hla	NOUN
fnp-8974	117	8	-	-	PUNCT
fnp-8974	117	9	e	e	NOUN
fnp-8974	117	10	antibody	antibody	NOUN
fnp-8974	117	11	on	on	ADP
fnp-8974	117	12	twenty	twenty	NUM
fnp-8974	117	13	ffpe	ffpe	NOUN
fnp-8974	117	14	muscle	muscle	NOUN
fnp-8974	117	15	biopsies	biopsy	NOUN
fnp-8974	117	16	with	with	ADP
fnp-8974	117	17	confirmed	confirm	VERB
fnp-8974	117	18	inflammation	inflammation	NOUN
fnp-8974	117	19	in	in	ADP
fnp-8974	117	20	which	which	PRON
fnp-8974	117	21	mhc	mhc	PROPN
fnp-8974	117	22	-	-	PUNCT
fnp-8974	117	23	i	i	PRON
fnp-8974	117	24	expression	expression	NOUN
fnp-8974	117	25	could	could	AUX
fnp-8974	117	26	not	not	PART
fnp-8974	117	27	be	be	AUX
fnp-8974	117	28	determined	determine	VERB
fnp-8974	117	29	up	up	ADP
fnp-8974	117	30	to	to	ADP
fnp-8974	117	31	now	now	ADV
fnp-8974	117	32	,	,	PUNCT
fnp-8974	117	33	as	as	ADV
fnp-8974	117	34	well	well	ADV
fnp-8974	117	35	as	as	ADP
fnp-8974	117	36	in	in	ADP
fnp-8974	117	37	ten	ten	NUM
fnp-8974	117	38	ffpe	ffpe	NOUN
fnp-8974	117	39	samples	sample	NOUN
fnp-8974	117	40	without	without	ADP
fnp-8974	117	41	inflammation	inflammation	NOUN
fnp-8974	117	42	as	as	ADP
fnp-8974	117	43	controls	control	NOUN
fnp-8974	117	44	.	.	PUNCT
fnp-8974	118	1	result	result	NOUN
fnp-8974	118	2	:	:	PUNCT
fnp-8974	119	1	immunoreaction	immunoreaction	NOUN
fnp-8974	119	2	of	of	ADP
fnp-8974	119	3	hla	hla	PROPN
fnp-8974	119	4	-	-	PUNCT
fnp-8974	119	5	e	e	NOUN
fnp-8974	119	6	antibody	antibody	NOUN
fnp-8974	119	7	successfully	successfully	ADV
fnp-8974	119	8	detected	detect	VERB
fnp-8974	119	9	sarcolemmal	sarcolemmal	ADJ
fnp-8974	119	10	and/or	and/or	CCONJ
fnp-8974	119	11	sarcoplasmatic	sarcoplasmatic	ADJ
fnp-8974	119	12	upregulation	upregulation	NOUN
fnp-8974	119	13	associated	associate	VERB
fnp-8974	119	14	with	with	ADP
fnp-8974	119	15	inflammation	inflammation	NOUN
fnp-8974	119	16	.	.	PUNCT
fnp-8974	120	1	this	this	PRON
fnp-8974	120	2	was	be	AUX
fnp-8974	120	3	true	true	ADJ
fnp-8974	120	4	for	for	ADP
fnp-8974	120	5	both	both	CCONJ
fnp-8974	120	6	frozen	frozen	ADJ
fnp-8974	120	7	and	and	CCONJ
fnp-8974	120	8	ffpe	ffpe	NOUN
fnp-8974	120	9	samples	sample	NOUN
fnp-8974	120	10	in	in	ADP
fnp-8974	120	11	specimens	specimen	NOUN
fnp-8974	120	12	in	in	ADP
fnp-8974	120	13	which	which	PRON
fnp-8974	120	14	the	the	DET
fnp-8974	120	15	diagnosis	diagnosis	NOUN
fnp-8974	120	16	of	of	ADP
fnp-8974	120	17	imm	imm	NOUN
fnp-8974	120	18	has	have	AUX
fnp-8974	120	19	been	be	AUX
fnp-8974	120	20	established	establish	VERB
fnp-8974	120	21	based	base	VERB
fnp-8974	120	22	on	on	ADP
fnp-8974	120	23	frozen	frozen	ADJ
fnp-8974	120	24	samples	sample	NOUN
fnp-8974	120	25	.	.	PUNCT
fnp-8974	121	1	in	in	ADP
fnp-8974	121	2	contrast	contrast	NOUN
fnp-8974	121	3	,	,	PUNCT
fnp-8974	121	4	in	in	ADP
fnp-8974	121	5	samples	sample	NOUN
fnp-8974	121	6	with	with	ADP
fnp-8974	121	7	neurogenic	neurogenic	ADJ
fnp-8974	121	8	muscular	muscular	ADJ
fnp-8974	121	9	atrophy	atrophy	NOUN
fnp-8974	121	10	both	both	CCONJ
fnp-8974	121	11	canonical	canonical	ADJ
fnp-8974	121	12	mhc	mhc	PROPN
fnp-8974	121	13	-	-	PUNCT
fnp-8974	121	14	i	i	PROPN
fnp-8974	121	15	and	and	CCONJ
fnp-8974	121	16	hla	hla	PROPN
fnp-8974	121	17	-	-	PUNCT
fnp-8974	121	18	e	e	NOUN
fnp-8974	121	19	expression	expression	NOUN
fnp-8974	121	20	were	be	AUX
fnp-8974	121	21	absent	absent	ADJ
fnp-8974	121	22	.	.	PUNCT
fnp-8974	122	1	conclusion	conclusion	NOUN
fnp-8974	122	2	:	:	PUNCT
fnp-8974	122	3	immunostaining	immunostaine	VERB
fnp-8974	122	4	for	for	ADP
fnp-8974	122	5	hla	hla	PROPN
fnp-8974	122	6	-	-	PUNCT
fnp-8974	122	7	e	e	NOUN
fnp-8974	122	8	enables	enable	VERB
fnp-8974	122	9	the	the	DET
fnp-8974	122	10	diagnosis	diagnosis	NOUN
fnp-8974	122	11	of	of	ADP
fnp-8974	122	12	imm	imm	NOUN
fnp-8974	122	13	using	use	VERB
fnp-8974	122	14	ffpe	ffpe	NOUN
fnp-8974	122	15	muscle	muscle	NOUN
fnp-8974	122	16	samples	sample	NOUN
fnp-8974	122	17	when	when	SCONJ
fnp-8974	122	18	frozen	frozen	ADJ
fnp-8974	122	19	tissue	tissue	NOUN
fnp-8974	122	20	is	be	AUX
fnp-8974	122	21	unavailable	unavailable	ADJ
fnp-8974	122	22	,	,	PUNCT
fnp-8974	122	23	offering	offer	VERB
fnp-8974	122	24	a	a	DET
fnp-8974	122	25	valuable	valuable	ADJ
fnp-8974	122	26	diagnostic	diagnostic	ADJ
fnp-8974	122	27	alternative	alternative	NOUN
fnp-8974	122	28	in	in	ADP
fnp-8974	122	29	cases	case	NOUN
fnp-8974	122	30	in	in	ADP
fnp-8974	122	31	which	which	PRON
fnp-8974	122	32	tissue	tissue	NOUN
fnp-8974	122	33	handling	handling	NOUN
fnp-8974	122	34	did	do	AUX
fnp-8974	122	35	not	not	PART
fnp-8974	122	36	adhere	adhere	VERB
fnp-8974	122	37	to	to	ADP
fnp-8974	122	38	the	the	DET
fnp-8974	122	39	guidelines	guideline	NOUN
fnp-8974	122	40	.	.	PUNCT
fnp-8974	123	1	v.	v.	ADP
fnp-8974	123	2	neurodegeneration	neurodegeneration	NOUN
fnp-8974	123	3	p09	p09	NOUN
fnp-8974	123	4	free	free	ADJ
fnp-8974	123	5	neuropathol	neuropathol	NOUN
fnp-8974	124	1	6:17:19	6:17:19	NUM
fnp-8974	124	2	the	the	DET
fnp-8974	124	3	interaction	interaction	NOUN
fnp-8974	124	4	between	between	ADP
fnp-8974	124	5	kallikrein-8	kallikrein-8	PROPN
fnp-8974	124	6	and	and	CCONJ
fnp-8974	124	7	its	its	PRON
fnp-8974	124	8	inhibitory	inhibitory	ADJ
fnp-8974	124	9	network	network	NOUN
fnp-8974	124	10	affects	affect	VERB
fnp-8974	124	11	alzheimer	alzheimer	PROPN
fnp-8974	124	12	’s	’s	PART
fnp-8974	124	13	disease	disease	NOUN
fnp-8974	124	14	paula	paula	PROPN
fnp-8974	124	15	pereira	pereira	PROPN
fnp-8974	124	16	de	de	PROPN
fnp-8974	124	17	almeida1	almeida1	PROPN
fnp-8974	124	18	,	,	PUNCT
fnp-8974	124	19	nicole	nicole	PROPN
fnp-8974	124	20	macha1	macha1	PROPN
fnp-8974	124	21	,	,	PUNCT
fnp-8974	124	22	arne	arne	ADJ
fnp-8974	124	23	herring1	herring1	PROPN
fnp-8974	124	24	,	,	PUNCT
fnp-8974	124	25	michael	michael	PROPN
fnp-8974	124	26	wissoly2	wissoly2	PROPN
fnp-8974	124	27	,	,	PUNCT
fnp-8974	124	28	ulf	ulf	PROPN
fnp-8974	124	29	brockmeier3	brockmeier3	PROPN
fnp-8974	124	30	,	,	PUNCT
fnp-8974	124	31	olga	olga	PROPN
fnp-8974	124	32	shevchuk4	shevchuk4	PROPN
fnp-8974	124	33	,	,	PUNCT
fnp-8974	124	34	stephanie	stephanie	PROPN
fnp-8974	124	35	schaefer	schaefer	PROPN
fnp-8974	124	36	-	-	PUNCT
fnp-8974	124	37	tautges4	tautges4	PROPN
fnp-8974	124	38	,	,	PUNCT
fnp-8974	124	39	hannah	hannah	PROPN
fnp-8974	124	40	voss4	voss4	PROPN
fnp-8974	124	41	,	,	PUNCT
fnp-8974	124	42	daniel	daniel	PROPN
fnp-8974	124	43	engel4	engel4	PROPN
fnp-8974	124	44	,	,	PUNCT
fnp-8974	124	45	syed	syed	ADJ
fnp-8974	124	46	ahsan	ahsan	PROPN
fnp-8974	124	47	raza1	raza1	PROPN
fnp-8974	124	48	,	,	PUNCT
fnp-8974	124	49	kathy	kathy	PROPN
fnp-8974	124	50	keyvani1	keyvani1	PROPN
fnp-8974	124	51	1	1	NUM
fnp-8974	124	52	university	university	NOUN
fnp-8974	124	53	hospital	hospital	NOUN
fnp-8974	124	54	essen	essen	PROPN
fnp-8974	124	55	,	,	PUNCT
fnp-8974	124	56	institute	institute	NOUN
fnp-8974	124	57	of	of	ADP
fnp-8974	124	58	neuropathology	neuropathology	NOUN
fnp-8974	124	59	,	,	PUNCT
fnp-8974	124	60	essen	essen	PROPN
fnp-8974	124	61	,	,	PUNCT
fnp-8974	124	62	germany	germany	PROPN
fnp-8974	124	63	2	2	NUM
fnp-8974	124	64	university	university	NOUN
fnp-8974	124	65	hospital	hospital	NOUN
fnp-8974	124	66	essen	essen	PROPN
fnp-8974	124	67	,	,	PUNCT
fnp-8974	124	68	institute	institute	PROPN
fnp-8974	124	69	of	of	ADP
fnp-8974	124	70	pathology	pathology	PROPN
fnp-8974	124	71	,	,	PUNCT
fnp-8974	124	72	essen	essen	PROPN
fnp-8974	124	73	,	,	PUNCT
fnp-8974	124	74	germany	germany	PROPN
fnp-8974	124	75	3	3	NUM
fnp-8974	124	76	university	university	PROPN
fnp-8974	124	77	hospital	hospital	NOUN
fnp-8974	124	78	essen	essen	PROPN
fnp-8974	124	79	,	,	PUNCT
fnp-8974	124	80	institute	institute	PROPN
fnp-8974	124	81	of	of	ADP
fnp-8974	124	82	neurology	neurology	NOUN
fnp-8974	124	83	,	,	PUNCT
fnp-8974	124	84	essen	essen	PROPN
fnp-8974	124	85	,	,	PUNCT
fnp-8974	124	86	germany	germany	PROPN
fnp-8974	124	87	4	4	NUM
fnp-8974	124	88	university	university	PROPN
fnp-8974	124	89	hospital	hospital	NOUN
fnp-8974	124	90	essen	essen	PROPN
fnp-8974	124	91	,	,	PUNCT
fnp-8974	124	92	institute	institute	NOUN
fnp-8974	124	93	of	of	ADP
fnp-8974	124	94	experimental	experimental	ADJ
fnp-8974	124	95	immunology	immunology	NOUN
fnp-8974	124	96	and	and	CCONJ
fnp-8974	124	97	imaging	imaging	NOUN
fnp-8974	124	98	,	,	PUNCT
fnp-8974	124	99	essen	essen	PROPN
fnp-8974	124	100	,	,	PUNCT
fnp-8974	124	101	germany	germany	PROPN
fnp-8974	124	102	background	background	NOUN
fnp-8974	124	103	:	:	PUNCT
fnp-8974	124	104	increased	increase	VERB
fnp-8974	124	105	kallikrein-8	kallikrein-8	PROPN
fnp-8974	124	106	(	(	PUNCT
fnp-8974	124	107	klk8	klk8	PROPN
fnp-8974	124	108	)	)	PUNCT
fnp-8974	124	109	level	level	NOUN
fnp-8974	124	110	seems	seem	VERB
fnp-8974	124	111	to	to	PART
fnp-8974	124	112	contribute	contribute	VERB
fnp-8974	124	113	to	to	ADP
fnp-8974	124	114	alzheimer	alzheimer	PROPN
fnp-8974	124	115	’s	’s	PART
fnp-8974	124	116	disease	disease	NOUN
fnp-8974	124	117	(	(	PUNCT
fnp-8974	124	118	ad	ad	NOUN
fnp-8974	124	119	)	)	PUNCT
fnp-8974	124	120	pathology	pathology	NOUN
fnp-8974	124	121	,	,	PUNCT
fnp-8974	124	122	but	but	CCONJ
fnp-8974	124	123	it	it	PRON
fnp-8974	124	124	remains	remain	VERB
fnp-8974	124	125	unknown	unknown	ADJ
fnp-8974	124	126	whether	whether	SCONJ
fnp-8974	124	127	a	a	DET
fnp-8974	124	128	disruption	disruption	NOUN
fnp-8974	124	129	of	of	ADP
fnp-8974	124	130	its	its	PRON
fnp-8974	124	131	inhibitory	inhibitory	ADJ
fnp-8974	124	132	network	network	NOUN
fnp-8974	124	133	is	be	AUX
fnp-8974	124	134	involved	involve	VERB
fnp-8974	124	135	.	.	PUNCT
fnp-8974	125	1	serpin	serpin	PROPN
fnp-8974	125	2	a3	a3	PROPN
fnp-8974	125	3	,	,	PUNCT
fnp-8974	125	4	serpin	serpin	PROPN
fnp-8974	125	5	b6	b6	PROPN
fnp-8974	125	6	,	,	PUNCT
fnp-8974	125	7	alpha-2	alpha-2	PROPN
fnp-8974	125	8	-	-	PUNCT
fnp-8974	125	9	macroglobulin	macroglobulin	PROPN
fnp-8974	125	10	(	(	PUNCT
fnp-8974	125	11	α2	α2	PROPN
fnp-8974	125	12	m	m	PROPN
fnp-8974	125	13	)	)	PUNCT
fnp-8974	125	14	,	,	PUNCT
fnp-8974	125	15	and	and	CCONJ
fnp-8974	125	16	the	the	DET
fnp-8974	125	17	acetylcholine	acetylcholine	NOUN
fnp-8974	125	18	(	(	PUNCT
fnp-8974	125	19	ach)producing	ach)produce	VERB
fnp-8974	125	20	protein	protein	NOUN
fnp-8974	125	21	pebp1	pebp1	NOUN
fnp-8974	125	22	are	be	AUX
fnp-8974	125	23	the	the	DET
fnp-8974	125	24	putative	putative	ADJ
fnp-8974	125	25	inhibitors	inhibitor	NOUN
fnp-8974	125	26	of	of	ADP
fnp-8974	125	27	klk8	klk8	PROPN
fnp-8974	125	28	.	.	PUNCT
fnp-8974	126	1	objective	objective	NOUN
fnp-8974	126	2	:	:	PUNCT
fnp-8974	126	3	to	to	PART
fnp-8974	126	4	examine	examine	VERB
fnp-8974	126	5	klk8↔inhibitor	klk8↔inhibitor	NOUN
fnp-8974	126	6	interactions	interaction	NOUN
fnp-8974	126	7	and	and	CCONJ
fnp-8974	126	8	their	their	PRON
fnp-8974	126	9	functional	functional	ADJ
fnp-8974	126	10	consequence	consequence	NOUN
fnp-8974	126	11	in	in	ADP
fnp-8974	126	12	ad	ad	NOUN
fnp-8974	126	13	pathology	pathology	NOUN
fnp-8974	126	14	.	.	PUNCT
fnp-8974	127	1	methods	method	NOUN
fnp-8974	127	2	:	:	PUNCT
fnp-8974	127	3	we	we	PRON
fnp-8974	127	4	combined	combine	VERB
fnp-8974	127	5	in	in	ADP
fnp-8974	127	6	silico	silico	NOUN
fnp-8974	127	7	modeling	modeling	NOUN
fnp-8974	127	8	and	and	CCONJ
fnp-8974	127	9	enzymatic	enzymatic	ADJ
fnp-8974	127	10	assays	assay	NOUN
fnp-8974	127	11	to	to	PART
fnp-8974	127	12	assess	assess	VERB
fnp-8974	127	13	binding	bind	VERB
fnp-8974	127	14	and	and	CCONJ
fnp-8974	127	15	inhibition	inhibition	NOUN
fnp-8974	127	16	.	.	PUNCT
fnp-8974	128	1	complex	complex	ADJ
fnp-8974	128	2	formation	formation	NOUN
fnp-8974	128	3	was	be	AUX
fnp-8974	128	4	validated	validate	VERB
fnp-8974	128	5	by	by	ADP
fnp-8974	128	6	co	co	NOUN
fnp-8974	128	7	-	-	NOUN
fnp-8974	128	8	immunoprecipitation	immunoprecipitation	ADJ
fnp-8974	128	9	,	,	PUNCT
fnp-8974	128	10	western	western	ADJ
fnp-8974	128	11	blot	blot	NOUN
fnp-8974	128	12	and	and	CCONJ
fnp-8974	128	13	mass	mass	ADJ
fnp-8974	128	14	spectrometry	spectrometry	NOUN
fnp-8974	128	15	,	,	PUNCT
fnp-8974	128	16	and	and	CCONJ
fnp-8974	128	17	was	be	AUX
fnp-8974	128	18	quantified	quantify	VERB
fnp-8974	128	19	in	in	ADP
fnp-8974	128	20	the	the	DET
fnp-8974	128	21	ad	ad	NOUN
fnp-8974	128	22	pathology	pathology	NOUN
fnp-8974	128	23	affected	affect	VERB
fnp-8974	128	24	human	human	ADJ
fnp-8974	128	25	and	and	CCONJ
fnp-8974	128	26	murine	murine	ADJ
fnp-8974	128	27	hippocampus	hippocampus	NOUN
fnp-8974	128	28	.	.	PUNCT
fnp-8974	129	1	cellular	cellular	ADJ
fnp-8974	129	2	models	model	NOUN
fnp-8974	129	3	(	(	PUNCT
fnp-8974	129	4	sh	sh	NOUN
fnp-8974	129	5	-	-	PUNCT
fnp-8974	129	6	sy5y	sy5y	NOUN
fnp-8974	129	7	,	,	PUNCT
fnp-8974	129	8	primary	primary	ADJ
fnp-8974	129	9	glia	glia	PROPN
fnp-8974	129	10	)	)	PUNCT
fnp-8974	129	11	tested	test	VERB
fnp-8974	129	12	klk8	klk8	PROPN
fnp-8974	129	13	inhibition	inhibition	VERB
fnp-8974	129	14	effects	effect	NOUN
fnp-8974	129	15	on	on	ADP
fnp-8974	129	16	aβ	aβ	PRON
fnp-8974	129	17	phagocytosis	phagocytosis	NOUN
fnp-8974	129	18	,	,	PUNCT
fnp-8974	129	19	neurite	neurite	ADJ
fnp-8974	129	20	outgrowth	outgrowth	NOUN
fnp-8974	129	21	,	,	PUNCT
fnp-8974	129	22	and	and	CCONJ
fnp-8974	129	23	ach	ach	PROPN
fnp-8974	129	24	production	production	NOUN
fnp-8974	129	25	.	.	PUNCT
fnp-8974	130	1	results	result	NOUN
fnp-8974	130	2	:	:	PUNCT
fnp-8974	130	3	a	a	DET
fnp-8974	130	4	protein	protein	NOUN
fnp-8974	130	5	-	-	PUNCT
fnp-8974	130	6	protein	protein	NOUN
fnp-8974	130	7	complexation	complexation	NOUN
fnp-8974	130	8	between	between	ADP
fnp-8974	130	9	klk8	klk8	PROPN
fnp-8974	130	10	and	and	CCONJ
fnp-8974	130	11	its	its	PRON
fnp-8974	130	12	putative	putative	ADJ
fnp-8974	130	13	inhibitors	inhibitor	NOUN
fnp-8974	130	14	was	be	AUX
fnp-8974	130	15	predicted	predict	VERB
fnp-8974	130	16	by	by	ADP
fnp-8974	130	17	alphafold	alphafold	ADJ
fnp-8974	130	18	artificial	artificial	ADJ
fnp-8974	130	19	intelligence	intelligence	NOUN
fnp-8974	130	20	(	(	PUNCT
fnp-8974	130	21	ai	ai	NOUN
fnp-8974	130	22	)	)	PUNCT
fnp-8974	130	23	.	.	PUNCT
fnp-8974	131	1	all	all	DET
fnp-8974	131	2	four	four	NUM
fnp-8974	131	3	inhibitors	inhibitor	NOUN
fnp-8974	131	4	bound	bind	VERB
fnp-8974	131	5	and	and	CCONJ
fnp-8974	131	6	inhibited	inhibit	VERB
fnp-8974	131	7	klk8	klk8	PROPN
fnp-8974	131	8	in	in	ADP
fnp-8974	131	9	vitro	vitro	X
fnp-8974	131	10	,	,	PUNCT
fnp-8974	131	11	and	and	CCONJ
fnp-8974	131	12	klk8	klk8	PROPN
fnp-8974	131	13	inhibition	inhibition	NOUN
fnp-8974	131	14	restored	restore	VERB
fnp-8974	131	15	neurite	neurite	ADJ
fnp-8974	131	16	outgrowth	outgrowth	NOUN
fnp-8974	131	17	and	and	CCONJ
fnp-8974	131	18	boosted	boost	VERB
fnp-8974	131	19	aβ	aβ	PRON
fnp-8974	131	20	clearance	clearance	NOUN
fnp-8974	131	21	in	in	ADP
fnp-8974	131	22	cellular	cellular	ADJ
fnp-8974	131	23	models	model	NOUN
fnp-8974	131	24	.	.	PUNCT
fnp-8974	132	1	klk8	klk8	PROPN
fnp-8974	132	2	complexes	complexe	VERB
fnp-8974	132	3	with	with	ADP
fnp-8974	132	4	serpin	serpin	PROPN
fnp-8974	132	5	a3	a3	PROPN
fnp-8974	132	6	,	,	PUNCT
fnp-8974	132	7	serpin	serpin	PROPN
fnp-8974	132	8	b6	b6	PROPN
fnp-8974	132	9	and	and	CCONJ
fnp-8974	132	10	α2	α2	PROPN
fnp-8974	132	11	m	m	PROPN
fnp-8974	132	12	were	be	AUX
fnp-8974	132	13	significantly	significantly	ADV
fnp-8974	132	14	reduced	reduce	VERB
fnp-8974	132	15	in	in	ADP
fnp-8974	132	16	human	human	NOUN
fnp-8974	132	17	(	(	PUNCT
fnp-8974	132	18	but	but	CCONJ
fnp-8974	132	19	not	not	PART
fnp-8974	132	20	murine	murine	ADJ
fnp-8974	132	21	)	)	PUNCT
fnp-8974	132	22	hippocampus	hippocampus	NOUN
fnp-8974	132	23	when	when	SCONJ
fnp-8974	132	24	affected	affect	VERB
fnp-8974	132	25	by	by	ADP
fnp-8974	132	26	ad	ad	NOUN
fnp-8974	132	27	pathology	pathology	NOUN
fnp-8974	132	28	.	.	PUNCT
fnp-8974	133	1	the	the	DET
fnp-8974	133	2	reduced	reduce	VERB
fnp-8974	133	3	ach	ach	PROPN
fnp-8974	133	4	levels	level	NOUN
fnp-8974	133	5	upon	upon	SCONJ
fnp-8974	133	6	klk8	klk8	PROPN
fnp-8974	133	7	exposure	exposure	NOUN
fnp-8974	133	8	in	in	ADP
fnp-8974	133	9	sh	sh	PROPN
fnp-8974	133	10	-	-	PUNCT
fnp-8974	133	11	sy5y	sy5y	PROPN
fnp-8974	133	12	cells	cell	NOUN
fnp-8974	133	13	were	be	AUX
fnp-8974	133	14	countered	counter	VERB
fnp-8974	133	15	when	when	SCONJ
fnp-8974	133	16	klk8	klk8	PROPN
fnp-8974	133	17	was	be	AUX
fnp-8974	133	18	pre	pre	VERB
fnp-8974	133	19	-	-	VERB
fnp-8974	133	20	incubated	incubate	VERB
fnp-8974	133	21	with	with	ADP
fnp-8974	133	22	pebp1	pebp1	NOUN
fnp-8974	133	23	.	.	PUNCT
fnp-8974	134	1	conclusion	conclusion	NOUN
fnp-8974	134	2	:	:	PUNCT
fnp-8974	134	3	our	our	PRON
fnp-8974	134	4	results	result	NOUN
fnp-8974	134	5	indicate	indicate	VERB
fnp-8974	134	6	that	that	SCONJ
fnp-8974	134	7	reduced	reduce	VERB
fnp-8974	134	8	klk8	klk8	PROPN
fnp-8974	134	9	complexation	complexation	NOUN
fnp-8974	134	10	with	with	ADP
fnp-8974	134	11	its	its	PRON
fnp-8974	134	12	inhibitors	inhibitor	NOUN
fnp-8974	134	13	α2	α2	PROPN
fnp-8974	134	14	m	m	PROPN
fnp-8974	134	15	serpin	serpin	PROPN
fnp-8974	134	16	a6	a6	PROPN
fnp-8974	134	17	and	and	CCONJ
fnp-8974	134	18	b6	b6	NOUN
fnp-8974	134	19	may	may	AUX
fnp-8974	134	20	contribute	contribute	VERB
fnp-8974	134	21	to	to	ADP
fnp-8974	134	22	higher	high	ADJ
fnp-8974	134	23	klk8	klk8	PROPN
fnp-8974	134	24	activity	activity	NOUN
fnp-8974	134	25	as	as	SCONJ
fnp-8974	134	26	seen	see	VERB
fnp-8974	134	27	in	in	ADP
fnp-8974	134	28	ad	ad	NOUN
fnp-8974	134	29	brain	brain	NOUN
fnp-8974	134	30	,	,	PUNCT
fnp-8974	134	31	while	while	SCONJ
fnp-8974	134	32	increased	increase	VERB
fnp-8974	134	33	klk8↔pebp1	klk8↔pebp1	PROPN
fnp-8974	134	34	interaction	interaction	NOUN
fnp-8974	134	35	might	might	AUX
fnp-8974	134	36	explain	explain	VERB
fnp-8974	134	37	the	the	DET
fnp-8974	134	38	compromised	compromised	ADJ
fnp-8974	134	39	cholinergic	cholinergic	NOUN
fnp-8974	134	40	signaling	signal	VERB
fnp-8974	134	41	in	in	ADP
fnp-8974	134	42	ad	ad	NOUN
fnp-8974	134	43	brain	brain	NOUN
fnp-8974	134	44	.	.	PUNCT
fnp-8974	135	1	these	these	DET
fnp-8974	135	2	results	result	NOUN
fnp-8974	135	3	underscore	underscore	VERB
fnp-8974	135	4	the	the	DET
fnp-8974	135	5	therapeutic	therapeutic	ADJ
fnp-8974	135	6	potential	potential	NOUN
fnp-8974	135	7	of	of	ADP
fnp-8974	135	8	targeting	target	VERB
fnp-8974	135	9	klk8	klk8	PROPN
fnp-8974	135	10	's	's	PART
fnp-8974	135	11	regulatory	regulatory	ADJ
fnp-8974	135	12	network	network	NOUN
fnp-8974	135	13	in	in	ADP
fnp-8974	135	14	ad	ad	NOUN
fnp-8974	135	15	.	.	PUNCT
fnp-8974	136	1	p10	p10	NOUN
fnp-8974	136	2	free	free	ADJ
fnp-8974	136	3	neuropathol	neuropathol	NOUN
fnp-8974	136	4	6:17:20	6:17:20	NUM
fnp-8974	136	5	associations	association	NOUN
fnp-8974	136	6	between	between	ADP
fnp-8974	136	7	age	age	NOUN
fnp-8974	136	8	,	,	PUNCT
fnp-8974	136	9	sex	sex	NOUN
fnp-8974	136	10	and	and	CCONJ
fnp-8974	136	11	apoe	apoe	ADJ
fnp-8974	136	12	with	with	ADP
fnp-8974	136	13	amyloid	amyloid	NOUN
fnp-8974	136	14	-	-	PUNCT
fnp-8974	136	15	beta	beta	NOUN
fnp-8974	136	16	,	,	PUNCT
fnp-8974	136	17	tau	tau	PROPN
fnp-8974	136	18	and	and	CCONJ
fnp-8974	136	19	α	α	X
fnp-8974	136	20	-	-	PUNCT
fnp-8974	136	21	synuclein	synuclein	NOUN
fnp-8974	136	22	loads	load	NOUN
fnp-8974	136	23	in	in	ADP
fnp-8974	136	24	alzheimer	alzheimer	PROPN
fnp-8974	136	25	’s	’s	PART
fnp-8974	136	26	disease	disease	NOUN
fnp-8974	136	27	antonia	antonia	PROPN
fnp-8974	136	28	neubauer1,2	neubauer1,2	PROPN
fnp-8974	136	29	,	,	PUNCT
fnp-8974	136	30	doris	doris	PROPN
fnp-8974	136	31	weissenbrunner1,2	weissenbrunner1,2	PROPN
fnp-8974	136	32	,	,	PUNCT
fnp-8974	136	33	susanna	susanna	PROPN
fnp-8974	136	34	pekrun1,2	pekrun1,2	PROPN
fnp-8974	136	35	,	,	PUNCT
fnp-8974	136	36	sigrun	sigrun	PROPN
fnp-8974	136	37	roeber1,2	roeber1,2	PROPN
fnp-8974	136	38	,	,	PUNCT
fnp-8974	136	39	viktoria	viktoria	PROPN
fnp-8974	136	40	ruf1,2	ruf1,2	PROPN
fnp-8974	136	41	,	,	PUNCT
fnp-8974	136	42	thomas	thomas	PROPN
fnp-8974	136	43	arzberger1,3	arzberger1,3	PROPN
fnp-8974	136	44	,	,	PUNCT
fnp-8974	136	45	paul	paul	PROPN
fnp-8974	136	46	feyen1,2	feyen1,2	PROPN
fnp-8974	136	47	,	,	PUNCT
fnp-8974	136	48	felix	felix	PROPN
fnp-8974	136	49	strübing1,2	strübing1,2	PROPN
fnp-8974	136	50	,	,	PUNCT
fnp-8974	136	51	jochen	jochen	PROPN
fnp-8974	136	52	herms1,2,4	herms1,2,4	PROPN
fnp-8974	136	53	1ludwig	1ludwig	NUM
fnp-8974	136	54	maximilians	maximilians	PROPN
fnp-8974	136	55	university	university	PROPN
fnp-8974	136	56	of	of	ADP
fnp-8974	136	57	munich	munich	PROPN
fnp-8974	136	58	,	,	PUNCT
fnp-8974	136	59	center	center	NOUN
fnp-8974	136	60	for	for	ADP
fnp-8974	136	61	neuropathology	neuropathology	NOUN
fnp-8974	136	62	and	and	CCONJ
fnp-8974	136	63	prion	prion	NOUN
fnp-8974	136	64	research	research	NOUN
fnp-8974	136	65	,	,	PUNCT
fnp-8974	136	66	munich	munich	PROPN
fnp-8974	136	67	,	,	PUNCT
fnp-8974	136	68	germany	germany	PROPN
fnp-8974	136	69	2	2	NUM
fnp-8974	136	70	german	german	ADJ
fnp-8974	136	71	center	center	NOUN
fnp-8974	136	72	for	for	ADP
fnp-8974	136	73	neurodegenerative	neurodegenerative	ADJ
fnp-8974	136	74	diseases	disease	NOUN
fnp-8974	136	75	(	(	PUNCT
fnp-8974	136	76	dzne	dzne	NOUN
fnp-8974	136	77	)	)	PUNCT
fnp-8974	136	78	,	,	PUNCT
fnp-8974	136	79	munich	munich	PROPN
fnp-8974	136	80	,	,	PUNCT
fnp-8974	136	81	germany	germany	PROPN
fnp-8974	136	82	3	3	NUM
fnp-8974	136	83	department	department	PROPN
fnp-8974	136	84	of	of	ADP
fnp-8974	136	85	psychiatry	psychiatry	NOUN
fnp-8974	136	86	and	and	CCONJ
fnp-8974	136	87	psychotherapy	psychotherapy	NOUN
fnp-8974	136	88	,	,	PUNCT
fnp-8974	136	89	university	university	NOUN
fnp-8974	136	90	hospital	hospital	NOUN
fnp-8974	136	91	,	,	PUNCT
fnp-8974	136	92	ludwig	ludwig	PROPN
fnp-8974	136	93	maximilians	maximilians	PROPN
fnp-8974	136	94	university	university	PROPN
fnp-8974	136	95	of	of	ADP
fnp-8974	136	96	munich	munich	PROPN
fnp-8974	136	97	,	,	PUNCT
fnp-8974	136	98	munich	munich	PROPN
fnp-8974	136	99	,	,	PUNCT
fnp-8974	136	100	germany	germany	PROPN
fnp-8974	136	101	4	4	NUM
fnp-8974	136	102	munich	munich	PROPN
fnp-8974	136	103	cluster	cluster	NOUN
fnp-8974	136	104	for	for	ADP
fnp-8974	136	105	systems	system	NOUN
fnp-8974	136	106	neurology	neurology	NOUN
fnp-8974	136	107	(	(	PUNCT
fnp-8974	136	108	synergy	synergy	NOUN
fnp-8974	136	109	)	)	PUNCT
fnp-8974	136	110	,	,	PUNCT
fnp-8974	136	111	munich	munich	PROPN
fnp-8974	136	112	,	,	PUNCT
fnp-8974	136	113	germany	germany	PROPN
fnp-8974	136	114	background	background	NOUN
fnp-8974	136	115	:	:	PUNCT
fnp-8974	136	116	age	age	NOUN
fnp-8974	136	117	,	,	PUNCT
fnp-8974	136	118	apoe	apoe	NOUN
fnp-8974	136	119	-	-	PUNCT
fnp-8974	136	120	genotype	genotype	NOUN
fnp-8974	136	121	and	and	CCONJ
fnp-8974	136	122	sex	sex	NOUN
fnp-8974	136	123	influence	influence	NOUN
fnp-8974	136	124	the	the	DET
fnp-8974	136	125	risk	risk	NOUN
fnp-8974	136	126	for	for	ADP
fnp-8974	136	127	alzheimer	alzheimer	PROPN
fnp-8974	136	128	’s	’s	PART
fnp-8974	136	129	disease	disease	NOUN
fnp-8974	136	130	(	(	PUNCT
fnp-8974	136	131	ad	ad	NOUN
fnp-8974	136	132	)	)	PUNCT
fnp-8974	136	133	and	and	CCONJ
fnp-8974	136	134	lewy	lewy	PROPN
fnp-8974	136	135	body	body	NOUN
fnp-8974	136	136	dementia	dementia	NOUN
fnp-8974	136	137	.	.	PUNCT
fnp-8974	137	1	the	the	DET
fnp-8974	137	2	relationship	relationship	NOUN
fnp-8974	137	3	with	with	ADP
fnp-8974	137	4	mixed	mixed	ADJ
fnp-8974	137	5	pathologies	pathology	NOUN
fnp-8974	137	6	requires	require	VERB
fnp-8974	137	7	further	further	ADJ
fnp-8974	137	8	elucidation	elucidation	NOUN
fnp-8974	137	9	.	.	PUNCT
fnp-8974	138	1	objectives	objective	NOUN
fnp-8974	138	2	:	:	PUNCT
fnp-8974	138	3	we	we	PRON
fnp-8974	138	4	aim	aim	VERB
fnp-8974	138	5	to	to	PART
fnp-8974	138	6	assess	assess	VERB
fnp-8974	138	7	the	the	DET
fnp-8974	138	8	association	association	NOUN
fnp-8974	138	9	between	between	ADP
fnp-8974	138	10	age	age	NOUN
fnp-8974	138	11	,	,	PUNCT
fnp-8974	138	12	apoe4	apoe4	PROPN
fnp-8974	138	13	,	,	PUNCT
fnp-8974	138	14	and	and	CCONJ
fnp-8974	138	15	sex	sex	NOUN
fnp-8974	138	16	with	with	ADP
fnp-8974	138	17	α	α	NOUN
fnp-8974	138	18	-	-	PUNCT
fnp-8974	138	19	synuclein	synuclein	NOUN
fnp-8974	138	20	(	(	PUNCT
fnp-8974	138	21	α	α	NOUN
fnp-8974	138	22	-	-	PUNCT
fnp-8974	138	23	syn	syn	NOUN
fnp-8974	138	24	)	)	PUNCT
fnp-8974	138	25	,	,	PUNCT
fnp-8974	138	26	amyloid	amyloid	NOUN
fnp-8974	138	27	-	-	PUNCT
fnp-8974	138	28	beta	beta	NOUN
fnp-8974	138	29	(	(	PUNCT
fnp-8974	138	30	aβ	aβ	NOUN
fnp-8974	138	31	)	)	PUNCT
fnp-8974	138	32	and	and	CCONJ
fnp-8974	138	33	tau	tau	PROPN
fnp-8974	138	34	load	load	NOUN
fnp-8974	138	35	in	in	ADP
fnp-8974	138	36	ad	ad	NOUN
fnp-8974	138	37	and	and	CCONJ
fnp-8974	138	38	how	how	SCONJ
fnp-8974	138	39	these	these	DET
fnp-8974	138	40	factors	factor	NOUN
fnp-8974	138	41	are	be	AUX
fnp-8974	138	42	distributed	distribute	VERB
fnp-8974	138	43	with	with	ADP
fnp-8974	138	44	variable	variable	ADJ
fnp-8974	138	45	α	α	PROPN
fnp-8974	138	46	-	-	PUNCT
fnp-8974	138	47	syn	syn	ADJ
fnp-8974	138	48	deposit	deposit	NOUN
fnp-8974	138	49	distributions	distribution	NOUN
fnp-8974	138	50	.	.	PUNCT
fnp-8974	139	1	methods	method	NOUN
fnp-8974	139	2	:	:	PUNCT
fnp-8974	139	3	72	72	NUM
fnp-8974	139	4	advanced	advanced	ADJ
fnp-8974	139	5	ad	ad	NOUN
fnp-8974	139	6	cases	case	NOUN
fnp-8974	139	7	of	of	ADP
fnp-8974	139	8	the	the	DET
fnp-8974	139	9	neurobiobank	neurobiobank	PROPN
fnp-8974	139	10	munich	munich	PROPN
fnp-8974	139	11	were	be	AUX
fnp-8974	139	12	included	include	VERB
fnp-8974	139	13	.	.	PUNCT
fnp-8974	140	1	α	α	X
fnp-8974	140	2	-	-	PUNCT
fnp-8974	140	3	syn	syn	PROPN
fnp-8974	140	4	,	,	PUNCT
fnp-8974	140	5	aβ	aβ	NOUN
fnp-8974	140	6	,	,	PUNCT
fnp-8974	140	7	and	and	CCONJ
fnp-8974	140	8	tau	tau	PROPN
fnp-8974	140	9	deposits	deposit	NOUN
fnp-8974	140	10	were	be	AUX
fnp-8974	140	11	automatically	automatically	ADV
fnp-8974	140	12	quantified	quantify	VERB
fnp-8974	140	13	with	with	ADP
fnp-8974	140	14	random	random	ADJ
fnp-8974	140	15	forest	forest	NOUN
fnp-8974	140	16	pixel	pixel	PROPN
fnp-8974	140	17	classifiers	classifier	NOUN
fnp-8974	140	18	on	on	ADP
fnp-8974	140	19	diaminobenzidine	diaminobenzidine	ADJ
fnp-8974	140	20	stainings	staining	NOUN
fnp-8974	140	21	for	for	ADP
fnp-8974	140	22	α	α	NOUN
fnp-8974	140	23	-	-	PUNCT
fnp-8974	140	24	syn42	syn42	ADJ
fnp-8974	140	25	,	,	PUNCT
fnp-8974	140	26	4g8	4g8	NUM
fnp-8974	140	27	,	,	PUNCT
fnp-8974	140	28	and	and	CCONJ
fnp-8974	140	29	at8	at8	PROPN
fnp-8974	140	30	in	in	ADP
fnp-8974	140	31	up	up	ADP
fnp-8974	140	32	to	to	PART
fnp-8974	140	33	28	28	NUM
fnp-8974	140	34	brain	brain	NOUN
fnp-8974	140	35	regions	region	NOUN
fnp-8974	140	36	per	per	ADP
fnp-8974	140	37	case	case	NOUN
fnp-8974	140	38	.	.	PUNCT
fnp-8974	141	1	associations	association	NOUN
fnp-8974	141	2	between	between	ADP
fnp-8974	141	3	deposit	deposit	NOUN
fnp-8974	141	4	loads	load	NOUN
fnp-8974	141	5	and	and	CCONJ
fnp-8974	141	6	age	age	NOUN
fnp-8974	141	7	at	at	ADP
fnp-8974	141	8	death	death	NOUN
fnp-8974	141	9	,	,	PUNCT
fnp-8974	141	10	sex	sex	NOUN
fnp-8974	141	11	,	,	PUNCT
fnp-8974	141	12	and	and	CCONJ
fnp-8974	141	13	apoe4	apoe4	PROPN
fnp-8974	141	14	were	be	AUX
fnp-8974	141	15	analyzed	analyze	VERB
fnp-8974	141	16	with	with	ADP
fnp-8974	141	17	multiple	multiple	ADJ
fnp-8974	141	18	linear	linear	ADJ
fnp-8974	141	19	regression	regression	NOUN
fnp-8974	141	20	models	model	NOUN
fnp-8974	141	21	.	.	PUNCT
fnp-8974	142	1	additionally	additionally	ADV
fnp-8974	142	2	,	,	PUNCT
fnp-8974	142	3	age	age	NOUN
fnp-8974	142	4	,	,	PUNCT
fnp-8974	142	5	sex	sex	NOUN
fnp-8974	142	6	,	,	PUNCT
fnp-8974	142	7	and	and	CCONJ
fnp-8974	142	8	apoe4	apoe4	PROPN
fnp-8974	142	9	carriage	carriage	NOUN
fnp-8974	142	10	were	be	AUX
fnp-8974	142	11	compared	compare	VERB
fnp-8974	142	12	between	between	ADP
fnp-8974	142	13	α	α	PROPN
fnp-8974	142	14	-	-	PUNCT
fnp-8974	142	15	syn	syn	PROPN
fnp-8974	142	16	co	co	NOUN
fnp-8974	142	17	-	-	NOUN
fnp-8974	142	18	pathology	pathology	NOUN
fnp-8974	142	19	distributions	distribution	NOUN
fnp-8974	142	20	.	.	PUNCT
fnp-8974	143	1	results	result	NOUN
fnp-8974	143	2	:	:	PUNCT
fnp-8974	143	3	while	while	SCONJ
fnp-8974	143	4	female	female	ADJ
fnp-8974	143	5	cases	case	NOUN
fnp-8974	143	6	showed	show	VERB
fnp-8974	143	7	a	a	DET
fnp-8974	143	8	significantly	significantly	ADV
fnp-8974	143	9	higher	high	ADJ
fnp-8974	143	10	cortical	cortical	ADJ
fnp-8974	143	11	and	and	CCONJ
fnp-8974	143	12	hippocampal	hippocampal	VERB
fnp-8974	143	13	aβ	aβ	DET
fnp-8974	143	14	load	load	NOUN
fnp-8974	143	15	,	,	PUNCT
fnp-8974	143	16	males	male	NOUN
fnp-8974	143	17	presented	present	VERB
fnp-8974	143	18	with	with	ADP
fnp-8974	143	19	a	a	DET
fnp-8974	143	20	higher	high	ADJ
fnp-8974	143	21	hippocampal	hippocampal	NOUN
fnp-8974	143	22	and	and	CCONJ
fnp-8974	143	23	amygdala	amygdala	NOUN
fnp-8974	143	24	-	-	PUNCT
fnp-8974	143	25	entorhinal	entorhinal	ADJ
fnp-8974	143	26	tau	tau	PROPN
fnp-8974	143	27	load	load	NOUN
fnp-8974	143	28	.	.	PUNCT
fnp-8974	144	1	patients	patient	NOUN
fnp-8974	144	2	with	with	ADP
fnp-8974	144	3	a	a	DET
fnp-8974	144	4	younger	young	ADJ
fnp-8974	144	5	age	age	NOUN
fnp-8974	144	6	at	at	ADP
fnp-8974	144	7	death	death	NOUN
fnp-8974	144	8	showed	show	VERB
fnp-8974	144	9	focally	focally	ADV
fnp-8974	144	10	higher	high	ADJ
fnp-8974	144	11	aβ	aβ	NOUN
fnp-8974	144	12	and	and	CCONJ
fnp-8974	144	13	tau	tau	PROPN
fnp-8974	144	14	loads	load	NOUN
fnp-8974	144	15	.	.	PUNCT
fnp-8974	145	1	apoe4	apoe4	PROPN
fnp-8974	145	2	carriers	carrier	NOUN
fnp-8974	145	3	had	have	VERB
fnp-8974	145	4	higher	high	ADJ
fnp-8974	145	5	cortical	cortical	ADJ
fnp-8974	145	6	aβ	aβ	NOUN
fnp-8974	145	7	loads	load	NOUN
fnp-8974	145	8	and	and	CCONJ
fnp-8974	145	9	an	an	DET
fnp-8974	145	10	increased	increase	VERB
fnp-8974	145	11	hippocampal	hippocampal	NOUN
fnp-8974	145	12	α	α	NOUN
fnp-8974	145	13	-	-	PUNCT
fnp-8974	145	14	syn	syn	NOUN
fnp-8974	145	15	load	load	NOUN
fnp-8974	145	16	.	.	PUNCT
fnp-8974	146	1	although	although	SCONJ
fnp-8974	146	2	not	not	PART
fnp-8974	146	3	significantly	significantly	ADV
fnp-8974	146	4	,	,	PUNCT
fnp-8974	146	5	there	there	PRON
fnp-8974	146	6	was	be	VERB
fnp-8974	146	7	a	a	DET
fnp-8974	146	8	trend	trend	NOUN
fnp-8974	146	9	towards	towards	ADP
fnp-8974	146	10	more	more	ADJ
fnp-8974	146	11	female	female	ADJ
fnp-8974	146	12	cases	case	NOUN
fnp-8974	146	13	and	and	CCONJ
fnp-8974	146	14	more	more	ADJ
fnp-8974	146	15	apoe4	apoe4	ADJ
fnp-8974	146	16	carriers	carrier	NOUN
fnp-8974	146	17	presenting	present	VERB
fnp-8974	146	18	with	with	ADP
fnp-8974	146	19	α	α	PROPN
fnp-8974	146	20	-	-	PUNCT
fnp-8974	146	21	syn	syn	NOUN
fnp-8974	146	22	co	co	NOUN
fnp-8974	146	23	-	-	NOUN
fnp-8974	146	24	pathology	pathology	NOUN
fnp-8974	146	25	.	.	PUNCT
fnp-8974	147	1	ad	ad	NOUN
fnp-8974	147	2	cases	case	NOUN
fnp-8974	147	3	with	with	ADP
fnp-8974	147	4	cortically	cortically	ADV
fnp-8974	147	5	disseminated	disseminate	VERB
fnp-8974	147	6	α	α	NOUN
fnp-8974	147	7	-	-	PUNCT
fnp-8974	147	8	syn	syn	ADJ
fnp-8974	147	9	deposits	deposit	NOUN
fnp-8974	147	10	tended	tend	VERB
fnp-8974	147	11	to	to	PART
fnp-8974	147	12	have	have	VERB
fnp-8974	147	13	a	a	DET
fnp-8974	147	14	lower	low	ADJ
fnp-8974	147	15	age	age	NOUN
fnp-8974	147	16	at	at	ADP
fnp-8974	147	17	death	death	NOUN
fnp-8974	147	18	.	.	PUNCT
fnp-8974	148	1	conclusion	conclusion	NOUN
fnp-8974	148	2	:	:	PUNCT
fnp-8974	148	3	despite	despite	SCONJ
fnp-8974	148	4	a	a	DET
fnp-8974	148	5	limited	limited	ADJ
fnp-8974	148	6	cohort	cohort	NOUN
fnp-8974	148	7	selection	selection	NOUN
fnp-8974	148	8	,	,	PUNCT
fnp-8974	148	9	age	age	NOUN
fnp-8974	148	10	,	,	PUNCT
fnp-8974	148	11	sex	sex	NOUN
fnp-8974	148	12	,	,	PUNCT
fnp-8974	148	13	and	and	CCONJ
fnp-8974	148	14	apoe	apoe	ADJ
fnp-8974	148	15	-	-	PUNCT
fnp-8974	148	16	genotype	genotype	NOUN
fnp-8974	148	17	showed	show	VERB
fnp-8974	148	18	associations	association	NOUN
fnp-8974	148	19	with	with	ADP
fnp-8974	148	20	aβ	aβ	ADP
fnp-8974	148	21	and	and	CCONJ
fnp-8974	148	22	tau	tau	PROPN
fnp-8974	148	23	load	load	NOUN
fnp-8974	148	24	,	,	PUNCT
fnp-8974	148	25	and	and	CCONJ
fnp-8974	148	26	α	α	X
fnp-8974	148	27	-	-	PUNCT
fnp-8974	148	28	syn	syn	PROPN
fnp-8974	148	29	co	co	NOUN
fnp-8974	148	30	-	-	NOUN
fnp-8974	148	31	pathology	pathology	NOUN
fnp-8974	148	32	in	in	ADP
fnp-8974	148	33	ad	ad	NOUN
fnp-8974	148	34	.	.	PUNCT
fnp-8974	149	1	therefore	therefore	ADV
fnp-8974	149	2	,	,	PUNCT
fnp-8974	149	3	these	these	DET
fnp-8974	149	4	factors	factor	NOUN
fnp-8974	149	5	should	should	AUX
fnp-8974	149	6	be	be	AUX
fnp-8974	149	7	considered	consider	VERB
fnp-8974	149	8	in	in	ADP
fnp-8974	149	9	patient	patient	ADJ
fnp-8974	149	10	stratification	stratification	NOUN
fnp-8974	149	11	for	for	ADP
fnp-8974	149	12	therapeutic	therapeutic	ADJ
fnp-8974	149	13	trials	trial	NOUN
fnp-8974	149	14	.	.	PUNCT
fnp-8974	150	1	p11	p11	ADJ
fnp-8974	150	2	free	free	ADJ
fnp-8974	150	3	neuropathol	neuropathol	NOUN
fnp-8974	150	4	6:17:21	6:17:21	NUM
fnp-8974	150	5	white	white	ADJ
fnp-8974	150	6	matter	matter	VERB
fnp-8974	150	7	granular	granular	ADJ
fnp-8974	150	8	astrocytic	astrocytic	ADJ
fnp-8974	150	9	tau	tau	PROPN
fnp-8974	150	10	inclusions	inclusion	NOUN
fnp-8974	150	11	are	be	AUX
fnp-8974	150	12	a	a	DET
fnp-8974	150	13	highly	highly	ADV
fnp-8974	150	14	consistent	consistent	ADJ
fnp-8974	150	15	feature	feature	NOUN
fnp-8974	150	16	in	in	ADP
fnp-8974	150	17	multiple	multiple	ADJ
fnp-8974	150	18	system	system	NOUN
fnp-8974	150	19	atrophy	atrophy	NOUN
fnp-8974	150	20	viktoria	viktoria	PROPN
fnp-8974	150	21	ruf1	ruf1	PROPN
fnp-8974	150	22	,	,	PUNCT
fnp-8974	150	23	doris	doris	PROPN
fnp-8974	150	24	weissenbrunner1,2	weissenbrunner1,2	PROPN
fnp-8974	150	25	,	,	PUNCT
fnp-8974	150	26	sigrun	sigrun	PROPN
fnp-8974	150	27	roeber1	roeber1	PROPN
fnp-8974	150	28	,	,	PUNCT
fnp-8974	150	29	thomas	thomas	PROPN
fnp-8974	150	30	arzberger1,2	arzberger1,2	PROPN
fnp-8974	150	31	,	,	PUNCT
fnp-8974	150	32	camelia	camelia	PROPN
fnp-8974	150	33	-	-	PROPN
fnp-8974	150	34	maria	maria	PROPN
fnp-8974	150	35	monoranu3	monoranu3	PROPN
fnp-8974	150	36	,	,	PUNCT
fnp-8974	150	37	paul	paul	PROPN
fnp-8974	150	38	feyen1,2	feyen1,2	PROPN
fnp-8974	150	39	,	,	PUNCT
fnp-8974	150	40	jochen	jochen	PROPN
fnp-8974	150	41	herms1,2,4	herms1,2,4	PROPN
fnp-8974	150	42	1	1	NUM
fnp-8974	150	43	center	center	NOUN
fnp-8974	150	44	for	for	ADP
fnp-8974	150	45	neuropathology	neuropathology	NOUN
fnp-8974	150	46	and	and	CCONJ
fnp-8974	150	47	prion	prion	NOUN
fnp-8974	150	48	research	research	NOUN
fnp-8974	150	49	,	,	PUNCT
fnp-8974	150	50	faculty	faculty	NOUN
fnp-8974	150	51	of	of	ADP
fnp-8974	150	52	medicine	medicine	NOUN
fnp-8974	150	53	,	,	PUNCT
fnp-8974	150	54	lmu	lmu	PROPN
fnp-8974	150	55	munich	munich	PROPN
fnp-8974	150	56	,	,	PUNCT
fnp-8974	150	57	munich	munich	PROPN
fnp-8974	150	58	,	,	PUNCT
fnp-8974	150	59	germany	germany	PROPN
fnp-8974	150	60	2	2	NUM
fnp-8974	150	61	german	german	ADJ
fnp-8974	150	62	center	center	NOUN
fnp-8974	150	63	for	for	ADP
fnp-8974	150	64	neurodegenerative	neurodegenerative	ADJ
fnp-8974	150	65	diseases	disease	NOUN
fnp-8974	150	66	(	(	PUNCT
fnp-8974	150	67	dzne	dzne	NOUN
fnp-8974	150	68	)	)	PUNCT
fnp-8974	151	1	e.	e.	PROPN
fnp-8974	151	2	v.	v.	PROPN
fnp-8974	151	3	,	,	PUNCT
fnp-8974	151	4	munich	munich	PROPN
fnp-8974	151	5	,	,	PUNCT
fnp-8974	151	6	germany	germany	PROPN
fnp-8974	151	7	3	3	NUM
fnp-8974	151	8	department	department	PROPN
fnp-8974	151	9	of	of	ADP
fnp-8974	151	10	neuropathology	neuropathology	NOUN
fnp-8974	151	11	,	,	PUNCT
fnp-8974	151	12	institute	institute	PROPN
fnp-8974	151	13	of	of	ADP
fnp-8974	151	14	pathology	pathology	PROPN
fnp-8974	151	15	,	,	PUNCT
fnp-8974	151	16	university	university	PROPN
fnp-8974	151	17	of	of	ADP
fnp-8974	151	18	würzburg	würzburg	PROPN
fnp-8974	151	19	,	,	PUNCT
fnp-8974	151	20	würzburg	würzburg	PROPN
fnp-8974	151	21	,	,	PUNCT
fnp-8974	151	22	germany	germany	PROPN
fnp-8974	151	23	4	4	NUM
fnp-8974	151	24	munich	munich	PROPN
fnp-8974	151	25	cluster	cluster	NOUN
fnp-8974	151	26	of	of	ADP
fnp-8974	151	27	systems	system	NOUN
fnp-8974	151	28	neurology	neurology	NOUN
fnp-8974	151	29	(	(	PUNCT
fnp-8974	151	30	synergy	synergy	NOUN
fnp-8974	151	31	)	)	PUNCT
fnp-8974	151	32	,	,	PUNCT
fnp-8974	151	33	munich	munich	PROPN
fnp-8974	151	34	,	,	PUNCT
fnp-8974	151	35	germany	germany	PROPN
fnp-8974	151	36	background	background	NOUN
fnp-8974	151	37	:	:	PUNCT
fnp-8974	151	38	multiple	multiple	ADJ
fnp-8974	151	39	system	system	NOUN
fnp-8974	151	40	atrophy	atrophy	NOUN
fnp-8974	151	41	(	(	PUNCT
fnp-8974	151	42	msa	msa	PROPN
fnp-8974	151	43	)	)	PUNCT
fnp-8974	151	44	is	be	AUX
fnp-8974	151	45	a	a	DET
fnp-8974	151	46	fatal	fatal	ADJ
fnp-8974	151	47	neurodegenerative	neurodegenerative	ADJ
fnp-8974	151	48	disorder	disorder	NOUN
fnp-8974	151	49	characterized	characterize	VERB
fnp-8974	151	50	by	by	ADP
fnp-8974	151	51	alpha	alpha	NOUN
fnp-8974	151	52	-	-	PUNCT
fnp-8974	151	53	synuclein	synuclein	NOUN
fnp-8974	151	54	aggregates	aggregate	NOUN
fnp-8974	151	55	in	in	ADP
fnp-8974	151	56	oligodendrocytes	oligodendrocyte	NOUN
fnp-8974	151	57	(	(	PUNCT
fnp-8974	151	58	glial	glial	ADJ
fnp-8974	151	59	cytoplasmic	cytoplasmic	ADJ
fnp-8974	151	60	inclusions	inclusion	NOUN
fnp-8974	151	61	;	;	PUNCT
fnp-8974	151	62	gcis	gcis	PROPN
fnp-8974	151	63	)	)	PUNCT
fnp-8974	151	64	.	.	PUNCT
fnp-8974	152	1	furthermore	furthermore	ADV
fnp-8974	152	2	,	,	PUNCT
fnp-8974	152	3	small	small	ADJ
fnp-8974	152	4	granular	granular	ADJ
fnp-8974	152	5	tau	tau	NOUN
fnp-8974	152	6	inclusions	inclusion	NOUN
fnp-8974	152	7	in	in	ADP
fnp-8974	152	8	white	white	ADJ
fnp-8974	152	9	matter	matter	NOUN
fnp-8974	152	10	have	have	AUX
fnp-8974	152	11	occasionally	occasionally	ADV
fnp-8974	152	12	been	be	AUX
fnp-8974	152	13	described	describe	VERB
fnp-8974	152	14	,	,	PUNCT
fnp-8974	152	15	however	however	ADV
fnp-8974	152	16	,	,	PUNCT
fnp-8974	152	17	these	these	PRON
fnp-8974	152	18	were	be	AUX
fnp-8974	152	19	controversially	controversially	ADV
fnp-8974	152	20	discussed	discuss	VERB
fnp-8974	152	21	.	.	PUNCT
fnp-8974	153	1	aim	aim	NOUN
fnp-8974	153	2	:	:	PUNCT
fnp-8974	153	3	based	base	VERB
fnp-8974	153	4	on	on	ADP
fnp-8974	153	5	our	our	PRON
fnp-8974	153	6	own	own	ADJ
fnp-8974	153	7	observations	observation	NOUN
fnp-8974	153	8	and	and	CCONJ
fnp-8974	153	9	our	our	PRON
fnp-8974	153	10	snrna	snrna	ADJ
fnp-8974	153	11	-	-	PUNCT
fnp-8974	153	12	seq	seq	NOUN
fnp-8974	153	13	data	datum	NOUN
fnp-8974	153	14	showing	show	VERB
fnp-8974	153	15	significant	significant	ADJ
fnp-8974	153	16	upregulation	upregulation	NOUN
fnp-8974	153	17	of	of	ADP
fnp-8974	153	18	mapt	mapt	NOUN
fnp-8974	153	19	in	in	ADP
fnp-8974	153	20	astrocytes	astrocyte	NOUN
fnp-8974	153	21	from	from	ADP
fnp-8974	153	22	msa	msa	PROPN
fnp-8974	153	23	patients	patient	NOUN
fnp-8974	153	24	,	,	PUNCT
fnp-8974	153	25	we	we	PRON
fnp-8974	153	26	aimed	aim	VERB
fnp-8974	153	27	to	to	PART
fnp-8974	153	28	characterize	characterize	VERB
fnp-8974	153	29	their	their	PRON
fnp-8974	153	30	presence	presence	NOUN
fnp-8974	153	31	more	more	ADV
fnp-8974	153	32	systematically	systematically	ADV
fnp-8974	153	33	.	.	PUNCT
fnp-8974	154	1	methods	method	NOUN
fnp-8974	154	2	:	:	PUNCT
fnp-8974	154	3	immunohistochemistry	immunohistochemistry	NOUN
fnp-8974	154	4	and	and	CCONJ
fnp-8974	154	5	immunofluorescence	immunofluorescence	NOUN
fnp-8974	154	6	were	be	AUX
fnp-8974	154	7	applied	apply	VERB
fnp-8974	154	8	to	to	ADP
fnp-8974	154	9	archived	archive	VERB
fnp-8974	154	10	ffpe	ffpe	ADJ
fnp-8974	154	11	tissue	tissue	NOUN
fnp-8974	154	12	from	from	ADP
fnp-8974	154	13	the	the	DET
fnp-8974	154	14	neurobiobank	neurobiobank	PROPN
fnp-8974	154	15	munich	munich	PROPN
fnp-8974	154	16	.	.	PUNCT
fnp-8974	155	1	results	result	NOUN
fnp-8974	155	2	:	:	PUNCT
fnp-8974	155	3	we	we	PRON
fnp-8974	155	4	confirmed	confirm	VERB
fnp-8974	155	5	the	the	DET
fnp-8974	155	6	presence	presence	NOUN
fnp-8974	155	7	of	of	ADP
fnp-8974	155	8	granular	granular	ADJ
fnp-8974	155	9	tau	tau	NOUN
fnp-8974	155	10	inclusions	inclusion	NOUN
fnp-8974	155	11	,	,	PUNCT
fnp-8974	155	12	which	which	PRON
fnp-8974	155	13	differ	differ	VERB
fnp-8974	155	14	from	from	ADP
fnp-8974	155	15	previously	previously	ADV
fnp-8974	155	16	described	describe	VERB
fnp-8974	155	17	tau	tau	PROPN
fnp-8974	155	18	pathologies	pathology	NOUN
fnp-8974	155	19	,	,	PUNCT
fnp-8974	155	20	and	and	CCONJ
fnp-8974	155	21	excluded	exclude	VERB
fnp-8974	155	22	tissue	tissue	NOUN
fnp-8974	155	23	processing	processing	NOUN
fnp-8974	155	24	or	or	CCONJ
fnp-8974	155	25	staining	stain	VERB
fnp-8974	155	26	artifacts	artifact	NOUN
fnp-8974	155	27	as	as	ADP
fnp-8974	155	28	their	their	PRON
fnp-8974	155	29	cause	cause	NOUN
fnp-8974	155	30	.	.	PUNCT
fnp-8974	156	1	the	the	DET
fnp-8974	156	2	inclusions	inclusion	NOUN
fnp-8974	156	3	,	,	PUNCT
fnp-8974	156	4	also	also	ADV
fnp-8974	156	5	positive	positive	ADJ
fnp-8974	156	6	for	for	ADP
fnp-8974	156	7	rd3	rd3	PROPN
fnp-8974	156	8	,	,	PUNCT
fnp-8974	156	9	rd4	rd4	PROPN
fnp-8974	156	10	,	,	PUNCT
fnp-8974	156	11	ptau	ptau	ADV
fnp-8974	156	12	-	-	PUNCT
fnp-8974	156	13	thr231	thr231	PROPN
fnp-8974	156	14	and	and	CCONJ
fnp-8974	156	15	ptau	ptau	ADV
fnp-8974	156	16	-	-	PUNCT
fnp-8974	156	17	ser396	ser396	NOUN
fnp-8974	156	18	,	,	PUNCT
fnp-8974	156	19	were	be	AUX
fnp-8974	156	20	closely	closely	ADV
fnp-8974	156	21	associated	associate	VERB
fnp-8974	156	22	with	with	ADP
fnp-8974	156	23	astrocytes	astrocyte	NOUN
fnp-8974	156	24	but	but	CCONJ
fnp-8974	156	25	not	not	PART
fnp-8974	156	26	with	with	ADP
fnp-8974	156	27	oligodendrocytes	oligodendrocyte	NOUN
fnp-8974	156	28	or	or	CCONJ
fnp-8974	156	29	microglia	microglia	NOUN
fnp-8974	156	30	.	.	PUNCT
fnp-8974	157	1	importantly	importantly	ADV
fnp-8974	157	2	,	,	PUNCT
fnp-8974	157	3	there	there	PRON
fnp-8974	157	4	was	be	VERB
fnp-8974	157	5	no	no	DET
fnp-8974	157	6	apparent	apparent	ADJ
fnp-8974	157	7	colocalization	colocalization	NOUN
fnp-8974	157	8	of	of	ADP
fnp-8974	157	9	tau	tau	PROPN
fnp-8974	157	10	inclusions	inclusion	NOUN
fnp-8974	157	11	and	and	CCONJ
fnp-8974	157	12	gcis	gcis	NOUN
fnp-8974	157	13	.	.	PUNCT
fnp-8974	158	1	in	in	ADP
fnp-8974	158	2	parallel	parallel	NOUN
fnp-8974	158	3	,	,	PUNCT
fnp-8974	158	4	we	we	PRON
fnp-8974	158	5	reviewed	review	VERB
fnp-8974	158	6	archival	archival	NOUN
fnp-8974	158	7	msa	msa	PROPN
fnp-8974	158	8	cases	case	NOUN
fnp-8974	158	9	along	along	ADP
fnp-8974	158	10	with	with	ADP
fnp-8974	158	11	cases	case	NOUN
fnp-8974	158	12	with	with	ADP
fnp-8974	158	13	other	other	ADJ
fnp-8974	158	14	neurodegenerative	neurodegenerative	ADJ
fnp-8974	158	15	diseases	disease	NOUN
fnp-8974	158	16	and	and	CCONJ
fnp-8974	158	17	healthy	healthy	ADJ
fnp-8974	158	18	controls	control	NOUN
fnp-8974	158	19	.	.	PUNCT
fnp-8974	159	1	while	while	SCONJ
fnp-8974	159	2	we	we	PRON
fnp-8974	159	3	detected	detect	VERB
fnp-8974	159	4	granular	granular	ADJ
fnp-8974	159	5	astrocytic	astrocytic	ADJ
fnp-8974	159	6	tau	tau	PROPN
fnp-8974	159	7	inclusions	inclusion	NOUN
fnp-8974	159	8	(	(	PUNCT
fnp-8974	159	9	gatis	gatis	NOUN
fnp-8974	159	10	)	)	PUNCT
fnp-8974	159	11	,	,	PUNCT
fnp-8974	159	12	though	though	SCONJ
fnp-8974	159	13	to	to	ADP
fnp-8974	159	14	different	different	ADJ
fnp-8974	159	15	extents	extent	NOUN
fnp-8974	159	16	,	,	PUNCT
fnp-8974	159	17	in	in	ADP
fnp-8974	159	18	all	all	DET
fnp-8974	159	19	msa	msa	PROPN
fnp-8974	159	20	cases	case	NOUN
fnp-8974	159	21	examined	examine	VERB
fnp-8974	159	22	(	(	PUNCT
fnp-8974	159	23	n	n	CCONJ
fnp-8974	159	24	 	 	SPACE
fnp-8974	159	25	=	=	NOUN
fnp-8974	159	26	 	 	SPACE
fnp-8974	159	27	45	45	NUM
fnp-8974	159	28	)	)	PUNCT
fnp-8974	159	29	,	,	PUNCT
fnp-8974	159	30	they	they	PRON
fnp-8974	159	31	were	be	AUX
fnp-8974	159	32	absent	absent	ADJ
fnp-8974	159	33	in	in	ADP
fnp-8974	159	34	other	other	ADJ
fnp-8974	159	35	neurodegenerative	neurodegenerative	ADJ
fnp-8974	159	36	diseases	disease	NOUN
fnp-8974	159	37	or	or	CCONJ
fnp-8974	159	38	healthy	healthy	ADJ
fnp-8974	159	39	controls	control	NOUN
fnp-8974	159	40	.	.	PUNCT
fnp-8974	160	1	gatis	gatis	PROPN
fnp-8974	160	2	were	be	AUX
fnp-8974	160	3	distributed	distribute	VERB
fnp-8974	160	4	throughout	throughout	ADP
fnp-8974	160	5	the	the	DET
fnp-8974	160	6	white	white	ADJ
fnp-8974	160	7	matter	matter	NOUN
fnp-8974	160	8	of	of	ADP
fnp-8974	160	9	the	the	DET
fnp-8974	160	10	entire	entire	ADJ
fnp-8974	160	11	brain	brain	NOUN
fnp-8974	160	12	and	and	CCONJ
fnp-8974	160	13	spinal	spinal	ADJ
fnp-8974	160	14	cord	cord	NOUN
fnp-8974	160	15	.	.	PUNCT
fnp-8974	161	1	the	the	DET
fnp-8974	161	2	regional	regional	ADJ
fnp-8974	161	3	distribution	distribution	NOUN
fnp-8974	161	4	closely	closely	ADV
fnp-8974	161	5	mirrored	mirror	VERB
fnp-8974	161	6	that	that	PRON
fnp-8974	161	7	of	of	ADP
fnp-8974	161	8	gcis	gcis	PROPN
fnp-8974	161	9	and	and	CCONJ
fnp-8974	161	10	we	we	PRON
fnp-8974	161	11	also	also	ADV
fnp-8974	161	12	found	find	VERB
fnp-8974	161	13	a	a	DET
fnp-8974	161	14	positive	positive	ADJ
fnp-8974	161	15	correlation	correlation	NOUN
fnp-8974	161	16	of	of	ADP
fnp-8974	161	17	the	the	DET
fnp-8974	161	18	burden	burden	NOUN
fnp-8974	161	19	of	of	ADP
fnp-8974	161	20	gcis	gcis	PROPN
fnp-8974	161	21	and	and	CCONJ
fnp-8974	161	22	gatis	gatis	PROPN
fnp-8974	161	23	.	.	PUNCT
fnp-8974	162	1	conclusions	conclusion	NOUN
fnp-8974	162	2	:	:	PUNCT
fnp-8974	162	3	gatis	gatis	NOUN
fnp-8974	162	4	appear	appear	VERB
fnp-8974	162	5	to	to	PART
fnp-8974	162	6	represent	represent	VERB
fnp-8974	162	7	a	a	DET
fnp-8974	162	8	highly	highly	ADV
fnp-8974	162	9	consistent	consistent	ADJ
fnp-8974	162	10	msa	msa	ADJ
fnp-8974	162	11	-	-	PUNCT
fnp-8974	162	12	specific	specific	ADJ
fnp-8974	162	13	tau	tau	PROPN
fnp-8974	162	14	pathology	pathology	NOUN
fnp-8974	162	15	,	,	PUNCT
fnp-8974	162	16	distinct	distinct	ADJ
fnp-8974	162	17	from	from	ADP
fnp-8974	162	18	previously	previously	ADV
fnp-8974	162	19	known	know	VERB
fnp-8974	162	20	tau	tau	PROPN
fnp-8974	162	21	pathologies	pathology	NOUN
fnp-8974	162	22	,	,	PUNCT
fnp-8974	162	23	with	with	ADP
fnp-8974	162	24	their	their	PRON
fnp-8974	162	25	distribution	distribution	NOUN
fnp-8974	162	26	strongly	strongly	ADV
fnp-8974	162	27	paralleling	paralleling	ADJ
fnp-8974	162	28	alpha	alpha	NOUN
fnp-8974	162	29	-	-	PUNCT
fnp-8974	162	30	synuclein	synuclein	NOUN
fnp-8974	162	31	pathology	pathology	NOUN
fnp-8974	162	32	.	.	PUNCT
fnp-8974	163	1	their	their	PRON
fnp-8974	163	2	pathological	pathological	ADJ
fnp-8974	163	3	significance	significance	NOUN
fnp-8974	163	4	,	,	PUNCT
fnp-8974	163	5	however	however	ADV
fnp-8974	163	6	,	,	PUNCT
fnp-8974	163	7	remains	remain	VERB
fnp-8974	163	8	to	to	PART
fnp-8974	163	9	be	be	AUX
fnp-8974	163	10	clarified	clarify	VERB
fnp-8974	163	11	.	.	PUNCT
fnp-8974	164	1	p12	p12	VERB
fnp-8974	164	2	free	free	ADJ
fnp-8974	164	3	neuropathol	neuropathol	NOUN
fnp-8974	164	4	6:17:22	6:17:22	NUM
fnp-8974	164	5	impact	impact	NOUN
fnp-8974	164	6	of	of	ADP
fnp-8974	164	7	the	the	DET
fnp-8974	164	8	gut	gut	NOUN
fnp-8974	164	9	microbiome	microbiome	NOUN
fnp-8974	164	10	on	on	ADP
fnp-8974	164	11	microglia	microglia	ADJ
fnp-8974	164	12	and	and	CCONJ
fnp-8974	164	13	alzheimer	alzheimer	PROPN
fnp-8974	164	14	’s	’s	PART
fnp-8974	164	15	disease	disease	NOUN
fnp-8974	164	16	in	in	ADP
fnp-8974	164	17	different	different	ADJ
fnp-8974	164	18	mouse	mouse	NOUN
fnp-8974	164	19	models	model	NOUN
fnp-8974	164	20	katharina	katharina	PROPN
fnp-8974	164	21	janvier1	janvier1	PROPN
fnp-8974	164	22	,	,	PUNCT
fnp-8974	164	23	amelie	amelie	PROPN
fnp-8974	164	24	weber2	weber2	PROPN
fnp-8974	164	25	,	,	PUNCT
fnp-8974	164	26	vadim	vadim	PROPN
fnp-8974	164	27	farztdinov3	farztdinov3	PROPN
fnp-8974	164	28	,	,	PUNCT
fnp-8974	164	29	stefan	stefan	PROPN
fnp-8974	164	30	jordan2	jordan2	PROPN
fnp-8974	164	31	,	,	PUNCT
fnp-8974	164	32	michael	michael	PROPN
fnp-8974	164	33	mülleder3	mülleder3	PROPN
fnp-8974	164	34	,	,	PUNCT
fnp-8974	164	35	marina	marina	PROPN
fnp-8974	164	36	jendrach4	jendrach4	PROPN
fnp-8974	164	37	,	,	PUNCT
fnp-8974	165	1	frank	frank	PROPN
fnp-8974	165	2	l.	l.	PROPN
fnp-8974	165	3	heppner4	heppner4	PROPN
fnp-8974	166	1	1	1	NUM
fnp-8974	166	2	department	department	NOUN
fnp-8974	166	3	der	der	PROPN
fnp-8974	166	4	neuropathology	neuropathology	NOUN
fnp-8974	166	5	,	,	PUNCT
fnp-8974	166	6	charité	charité	PROPN
fnp-8974	166	7	,	,	PUNCT
fnp-8974	166	8	berlin	berlin	PROPN
fnp-8974	166	9	,	,	PUNCT
fnp-8974	166	10	germany	germany	PROPN
fnp-8974	166	11	2	2	NUM
fnp-8974	166	12	department	department	NOUN
fnp-8974	166	13	of	of	ADP
fnp-8974	166	14	microbiology	microbiology	NOUN
fnp-8974	166	15	and	and	CCONJ
fnp-8974	166	16	infection	infection	NOUN
fnp-8974	166	17	immunology	immunology	NOUN
fnp-8974	166	18	,	,	PUNCT
fnp-8974	166	19	charité	charité	PROPN
fnp-8974	166	20	–	–	PUNCT
fnp-8974	166	21	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	166	22	berlin	berlin	PROPN
fnp-8974	166	23	,	,	PUNCT
fnp-8974	166	24	berlin	berlin	PROPN
fnp-8974	166	25	,	,	PUNCT
fnp-8974	166	26	germany	germany	PROPN
fnp-8974	166	27	3	3	NUM
fnp-8974	166	28	core	core	NOUN
fnp-8974	166	29	facility	facility	NOUN
fnp-8974	166	30	high	high	ADJ
fnp-8974	166	31	-	-	PUNCT
fnp-8974	166	32	throughput	throughput	NOUN
fnp-8974	166	33	mass	mass	NOUN
fnp-8974	166	34	spectrometry	spectrometry	NOUN
fnp-8974	166	35	,	,	PUNCT
fnp-8974	166	36	charité	charité	PROPN
fnp-8974	166	37	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	166	38	berlin	berlin	PROPN
fnp-8974	166	39	,	,	PUNCT
fnp-8974	166	40	berlin	berlin	PROPN
fnp-8974	166	41	,	,	PUNCT
fnp-8974	166	42	germany	germany	PROPN
fnp-8974	166	43	4	4	NUM
fnp-8974	166	44	department	department	NOUN
fnp-8974	166	45	of	of	ADP
fnp-8974	166	46	neuropathology	neuropathology	NOUN
fnp-8974	166	47	,	,	PUNCT
fnp-8974	166	48	charité	charité	PROPN
fnp-8974	166	49	–	–	PUNCT
fnp-8974	166	50	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	166	51	berlin	berlin	PROPN
fnp-8974	166	52	,	,	PUNCT
fnp-8974	166	53	berlin	berlin	PROPN
fnp-8974	166	54	,	,	PUNCT
fnp-8974	166	55	germany	germany	PROPN
fnp-8974	166	56	background	background	NOUN
fnp-8974	166	57	:	:	PUNCT
fnp-8974	166	58	the	the	DET
fnp-8974	166	59	gut	gut	NOUN
fnp-8974	166	60	microbiome	microbiome	NOUN
fnp-8974	166	61	plays	play	VERB
fnp-8974	166	62	a	a	DET
fnp-8974	166	63	crucial	crucial	ADJ
fnp-8974	166	64	role	role	NOUN
fnp-8974	166	65	in	in	ADP
fnp-8974	166	66	shaping	shape	VERB
fnp-8974	166	67	the	the	DET
fnp-8974	166	68	immune	immune	ADJ
fnp-8974	166	69	response	response	NOUN
fnp-8974	166	70	,	,	PUNCT
fnp-8974	166	71	which	which	PRON
fnp-8974	166	72	is	be	AUX
fnp-8974	166	73	closely	closely	ADV
fnp-8974	166	74	linked	link	VERB
fnp-8974	166	75	to	to	ADP
fnp-8974	166	76	the	the	DET
fnp-8974	166	77	development	development	NOUN
fnp-8974	166	78	and	and	CCONJ
fnp-8974	166	79	progression	progression	NOUN
fnp-8974	166	80	of	of	ADP
fnp-8974	166	81	alzheimer	alzheimer	PROPN
fnp-8974	166	82	's	's	PART
fnp-8974	166	83	disease	disease	NOUN
fnp-8974	166	84	(	(	PUNCT
fnp-8974	166	85	ad	ad	NOUN
fnp-8974	166	86	)	)	PUNCT
fnp-8974	166	87	.	.	PUNCT
fnp-8974	167	1	standard	standard	ADJ
fnp-8974	167	2	laboratory	laboratory	NOUN
fnp-8974	167	3	mice	mouse	NOUN
fnp-8974	167	4	,	,	PUNCT
fnp-8974	167	5	known	know	VERB
fnp-8974	167	6	as	as	ADP
fnp-8974	167	7	spf	spf	ADJ
fnp-8974	167	8	mice	mouse	NOUN
fnp-8974	167	9	,	,	PUNCT
fnp-8974	167	10	have	have	VERB
fnp-8974	167	11	a	a	DET
fnp-8974	167	12	limited	limited	ADJ
fnp-8974	167	13	and	and	CCONJ
fnp-8974	167	14	less	less	ADV
fnp-8974	167	15	diverse	diverse	ADJ
fnp-8974	167	16	microbiome	microbiome	NOUN
fnp-8974	167	17	than	than	ADP
fnp-8974	167	18	mice	mouse	NOUN
fnp-8974	167	19	living	live	VERB
fnp-8974	167	20	in	in	ADP
fnp-8974	167	21	the	the	DET
fnp-8974	167	22	wild	wild	ADJ
fnp-8974	167	23	or	or	CCONJ
fnp-8974	167	24	humans	human	NOUN
fnp-8974	167	25	,	,	PUNCT
fnp-8974	167	26	resulting	result	VERB
fnp-8974	167	27	in	in	ADP
fnp-8974	167	28	an	an	DET
fnp-8974	167	29	immune	immune	ADJ
fnp-8974	167	30	system	system	NOUN
fnp-8974	167	31	that	that	PRON
fnp-8974	167	32	may	may	AUX
fnp-8974	167	33	not	not	PART
fnp-8974	167	34	fully	fully	ADV
fnp-8974	167	35	reflect	reflect	VERB
fnp-8974	167	36	the	the	DET
fnp-8974	167	37	immune	immune	ADJ
fnp-8974	167	38	response	response	NOUN
fnp-8974	167	39	of	of	ADP
fnp-8974	167	40	adult	adult	NOUN
fnp-8974	167	41	human	human	NOUN
fnp-8974	167	42	.	.	PUNCT
fnp-8974	168	1	this	this	DET
fnp-8974	168	2	difference	difference	NOUN
fnp-8974	168	3	may	may	AUX
fnp-8974	168	4	potentially	potentially	ADV
fnp-8974	168	5	reduce	reduce	VERB
fnp-8974	168	6	their	their	PRON
fnp-8974	168	7	translational	translational	ADJ
fnp-8974	168	8	relevance	relevance	NOUN
fnp-8974	168	9	.	.	PUNCT
fnp-8974	169	1	objective(s	objective(s	NOUN
fnp-8974	169	2	):	):	PUNCT
fnp-8974	169	3	wildling	wildle	VERB
fnp-8974	169	4	mice	mouse	NOUN
fnp-8974	169	5	,	,	PUNCT
fnp-8974	169	6	are	be	AUX
fnp-8974	169	7	laboratory	laboratory	NOUN
fnp-8974	169	8	mice	mouse	NOUN
fnp-8974	169	9	that	that	PRON
fnp-8974	169	10	have	have	VERB
fnp-8974	169	11	a	a	DET
fnp-8974	169	12	natural	natural	ADJ
fnp-8974	169	13	microbiome	microbiome	NOUN
fnp-8974	169	14	,	,	PUNCT
fnp-8974	169	15	comparable	comparable	ADJ
fnp-8974	169	16	to	to	ADP
fnp-8974	169	17	a	a	DET
fnp-8974	169	18	mouse	mouse	NOUN
fnp-8974	169	19	in	in	ADP
fnp-8974	169	20	the	the	DET
fnp-8974	169	21	wild	wild	NOUN
fnp-8974	169	22	.	.	PUNCT
fnp-8974	170	1	we	we	PRON
fnp-8974	170	2	are	be	AUX
fnp-8974	170	3	part	part	NOUN
fnp-8974	170	4	of	of	ADP
fnp-8974	170	5	the	the	DET
fnp-8974	170	6	framework	framework	NOUN
fnp-8974	170	7	of	of	ADP
fnp-8974	170	8	the	the	DET
fnp-8974	170	9	"	"	PUNCT
fnp-8974	170	10	charité	charité	ADJ
fnp-8974	170	11	3r	3r	NOUN
fnp-8974	170	12	wildling	wildle	VERB
fnp-8974	170	13	mice	mouse	NOUN
fnp-8974	170	14	in	in	ADP
fnp-8974	170	15	health	health	NOUN
fnp-8974	170	16	and	and	CCONJ
fnp-8974	170	17	disease	disease	NOUN
fnp-8974	170	18	"	"	PUNCT
fnp-8974	170	19	consortium	consortium	NOUN
fnp-8974	170	20	,	,	PUNCT
fnp-8974	170	21	where	where	SCONJ
fnp-8974	170	22	the	the	DET
fnp-8974	170	23	wildling	wildle	VERB
fnp-8974	170	24	mouse	mouse	NOUN
fnp-8974	170	25	is	be	AUX
fnp-8974	170	26	validated	validate	VERB
fnp-8974	170	27	in	in	ADP
fnp-8974	170	28	different	different	ADJ
fnp-8974	170	29	pathological	pathological	ADJ
fnp-8974	170	30	settings	setting	NOUN
fnp-8974	170	31	.	.	PUNCT
fnp-8974	171	1	question(s	question(s	PROPN
fnp-8974	171	2	):	):	PUNCT
fnp-8974	171	3	do	do	AUX
fnp-8974	171	4	wildling	wildle	VERB
fnp-8974	171	5	mice	mouse	NOUN
fnp-8974	171	6	provide	provide	VERB
fnp-8974	171	7	a	a	DET
fnp-8974	171	8	more	more	ADV
fnp-8974	171	9	translationally	translationally	ADV
fnp-8974	171	10	relevant	relevant	ADJ
fnp-8974	171	11	model	model	NOUN
fnp-8974	171	12	for	for	ADP
fnp-8974	171	13	studying	study	VERB
fnp-8974	171	14	alzheimer	alzheimer	NOUN
fnp-8974	171	15	’s	’s	PART
fnp-8974	171	16	disease	disease	NOUN
fnp-8974	171	17	?	?	PUNCT
fnp-8974	172	1	method(s	method(	VERB
fnp-8974	172	2	):	):	PUNCT
fnp-8974	172	3	ad	ad	NOUN
fnp-8974	172	4	pathology	pathology	NOUN
fnp-8974	172	5	was	be	AUX
fnp-8974	172	6	assessed	assess	VERB
fnp-8974	172	7	in	in	ADP
fnp-8974	172	8	spf	spf	NOUN
fnp-8974	172	9	and	and	CCONJ
fnp-8974	172	10	wildling	wildle	VERB
fnp-8974	172	11	mice	mouse	NOUN
fnp-8974	172	12	using	use	VERB
fnp-8974	172	13	electrochemiluminescence	electrochemiluminescence	NOUN
fnp-8974	172	14	assays	assay	NOUN
fnp-8974	172	15	,	,	PUNCT
fnp-8974	172	16	mass	mass	ADJ
fnp-8974	172	17	spectrometry	spectrometry	NOUN
fnp-8974	172	18	,	,	PUNCT
fnp-8974	172	19	and	and	CCONJ
fnp-8974	172	20	immunohistochemistry	immunohistochemistry	NOUN
fnp-8974	172	21	.	.	PUNCT
fnp-8974	173	1	gut	gut	NOUN
fnp-8974	173	2	microbiota	microbiota	NOUN
fnp-8974	173	3	composition	composition	NOUN
fnp-8974	173	4	was	be	AUX
fnp-8974	173	5	analysed	analyse	VERB
fnp-8974	173	6	,	,	PUNCT
fnp-8974	173	7	and	and	CCONJ
fnp-8974	173	8	immune	immune	ADJ
fnp-8974	173	9	profiling	profiling	NOUN
fnp-8974	173	10	was	be	AUX
fnp-8974	173	11	performed	perform	VERB
fnp-8974	173	12	by	by	ADP
fnp-8974	173	13	flow	flow	NOUN
fnp-8974	173	14	cytometry	cytometry	NOUN
fnp-8974	173	15	.	.	PUNCT
fnp-8974	174	1	result(s	result(s	PROPN
fnp-8974	174	2	):	):	PUNCT
fnp-8974	174	3	we	we	PRON
fnp-8974	174	4	examined	examine	VERB
fnp-8974	174	5	wildtype	wildtype	NOUN
fnp-8974	174	6	wildling	wildle	VERB
fnp-8974	174	7	mice	mouse	NOUN
fnp-8974	174	8	and	and	CCONJ
fnp-8974	174	9	transgenic	transgenic	VERB
fnp-8974	174	10	appps1.wildling	appps1.wildle	VERB
fnp-8974	174	11	mice	mouse	NOUN
fnp-8974	174	12	in	in	ADP
fnp-8974	174	13	direct	direct	ADJ
fnp-8974	174	14	comparison	comparison	NOUN
fnp-8974	174	15	to	to	ADP
fnp-8974	174	16	their	their	PRON
fnp-8974	174	17	spf	spf	ADJ
fnp-8974	174	18	counterparts	counterpart	NOUN
fnp-8974	174	19	.	.	PUNCT
fnp-8974	175	1	wildling	wildle	VERB
fnp-8974	175	2	mice	mouse	NOUN
fnp-8974	175	3	displayed	display	VERB
fnp-8974	175	4	a	a	DET
fnp-8974	175	5	significantly	significantly	ADV
fnp-8974	175	6	different	different	ADJ
fnp-8974	175	7	gut	gut	NOUN
fnp-8974	175	8	microbiome	microbiome	NOUN
fnp-8974	175	9	composition	composition	NOUN
fnp-8974	175	10	and	and	CCONJ
fnp-8974	175	11	immune	immune	ADJ
fnp-8974	175	12	cell	cell	NOUN
fnp-8974	175	13	population	population	NOUN
fnp-8974	175	14	.	.	PUNCT
fnp-8974	176	1	notably	notably	ADV
fnp-8974	176	2	,	,	PUNCT
fnp-8974	176	3	appps1.wildling	appps1.wildle	VERB
fnp-8974	176	4	mice	mouse	NOUN
fnp-8974	176	5	showed	show	VERB
fnp-8974	176	6	signs	sign	NOUN
fnp-8974	176	7	of	of	ADP
fnp-8974	176	8	ad	ad	NOUN
fnp-8974	176	9	-	-	PUNCT
fnp-8974	176	10	related	relate	VERB
fnp-8974	176	11	pathology	pathology	NOUN
fnp-8974	176	12	already	already	ADV
fnp-8974	176	13	at	at	ADP
fnp-8974	176	14	early	early	ADJ
fnp-8974	176	15	disease	disease	NOUN
fnp-8974	176	16	stages	stage	NOUN
fnp-8974	176	17	,	,	PUNCT
fnp-8974	176	18	earlier	early	ADV
fnp-8974	176	19	and	and	CCONJ
fnp-8974	176	20	more	more	ADV
fnp-8974	176	21	pronounced	pronounced	ADJ
fnp-8974	176	22	than	than	ADP
fnp-8974	176	23	in	in	ADP
fnp-8974	176	24	spf	spf	ADJ
fnp-8974	176	25	mice	mouse	NOUN
fnp-8974	176	26	.	.	PUNCT
fnp-8974	177	1	conclusion(s	conclusion(s	NOUN
fnp-8974	177	2	):	):	PUNCT
fnp-8974	177	3	our	our	PRON
fnp-8974	177	4	results	result	NOUN
fnp-8974	177	5	suggest	suggest	VERB
fnp-8974	177	6	that	that	SCONJ
fnp-8974	177	7	wild	wild	ADJ
fnp-8974	177	8	-	-	PUNCT
fnp-8974	177	9	type	type	NOUN
fnp-8974	177	10	mice	mouse	NOUN
fnp-8974	177	11	more	more	ADV
fnp-8974	177	12	accurately	accurately	ADV
fnp-8974	177	13	reflect	reflect	VERB
fnp-8974	177	14	important	important	ADJ
fnp-8974	177	15	aspects	aspect	NOUN
fnp-8974	177	16	of	of	ADP
fnp-8974	177	17	human	human	ADJ
fnp-8974	177	18	ad	ad	NOUN
fnp-8974	177	19	pathology	pathology	NOUN
fnp-8974	177	20	,	,	PUNCT
fnp-8974	177	21	particularly	particularly	ADV
fnp-8974	177	22	regarding	regard	VERB
fnp-8974	177	23	gut	gut	NOUN
fnp-8974	177	24	-	-	PUNCT
fnp-8974	177	25	brain	brain	NOUN
fnp-8974	177	26	interactions	interaction	NOUN
fnp-8974	177	27	.	.	PUNCT
fnp-8974	178	1	p13	p13	PROPN
fnp-8974	178	2	free	free	ADJ
fnp-8974	178	3	neuropathol	neuropathol	NOUN
fnp-8974	178	4	6:17:23	6:17:23	NUM
fnp-8974	178	5	first	first	ADJ
fnp-8974	178	6	report	report	NOUN
fnp-8974	178	7	of	of	ADP
fnp-8974	178	8	clinico	clinico	NOUN
fnp-8974	178	9	-	-	PUNCT
fnp-8974	178	10	pathological	pathological	ADJ
fnp-8974	178	11	features	feature	NOUN
fnp-8974	178	12	associated	associate	VERB
fnp-8974	178	13	with	with	ADP
fnp-8974	178	14	tardbp	tardbp	NOUN
fnp-8974	178	15	p.m311v	p.m311v	PROPN
fnp-8974	178	16	mutation	mutation	NOUN
fnp-8974	178	17	alberto	alberto	PROPN
fnp-8974	178	18	grassini1	grassini1	PROPN
fnp-8974	178	19	,	,	PUNCT
fnp-8974	178	20	johannes	johannes	PROPN
fnp-8974	178	21	prudlo2,3	prudlo2,3	PROPN
fnp-8974	178	22	,	,	PUNCT
fnp-8974	178	23	hermann	hermann	PROPN
fnp-8974	178	24	andreas2,4	andreas2,4	PROPN
fnp-8974	178	25	,	,	PUNCT
fnp-8974	178	26	manuela	manuela	PROPN
fnp-8974	178	27	neumann5,6	neumann5,6	VERB
fnp-8974	178	28	1	1	NUM
fnp-8974	178	29	uniklinikum	uniklinikum	NOUN
fnp-8974	178	30	tübingen	tübingen	NOUN
fnp-8974	178	31	,	,	PUNCT
fnp-8974	178	32	neuropathology	neuropathology	NOUN
fnp-8974	178	33	,	,	PUNCT
fnp-8974	178	34	tübingen	tübingen	PROPN
fnp-8974	178	35	,	,	PUNCT
fnp-8974	178	36	germany	germany	PROPN
fnp-8974	178	37	2	2	NUM
fnp-8974	178	38	university	university	NOUN
fnp-8974	178	39	medical	medical	ADJ
fnp-8974	178	40	center	center	NOUN
fnp-8974	178	41	rostock	rostock	PROPN
fnp-8974	178	42	,	,	PUNCT
fnp-8974	178	43	rostock	rostock	PROPN
fnp-8974	178	44	,	,	PUNCT
fnp-8974	178	45	germany	germany	PROPN
fnp-8974	178	46	3	3	NUM
fnp-8974	178	47	german	german	ADJ
fnp-8974	178	48	center	center	NOUN
fnp-8974	178	49	for	for	ADP
fnp-8974	178	50	neurodegenerative	neurodegenerative	ADJ
fnp-8974	178	51	diseases	disease	NOUN
fnp-8974	178	52	,	,	PUNCT
fnp-8974	178	53	rostock	rostock	PROPN
fnp-8974	178	54	,	,	PUNCT
fnp-8974	178	55	germany	germany	PROPN
fnp-8974	178	56	4	4	NUM
fnp-8974	178	57	center	center	NOUN
fnp-8974	178	58	for	for	ADP
fnp-8974	178	59	transdisciplinary	transdisciplinary	ADJ
fnp-8974	178	60	neurosciences	neuroscience	NOUN
fnp-8974	178	61	rostock	rostock	NOUN
fnp-8974	178	62	,	,	PUNCT
fnp-8974	178	63	rostock	rostock	PROPN
fnp-8974	178	64	,	,	PUNCT
fnp-8974	178	65	germany	germany	PROPN
fnp-8974	178	66	5	5	NUM
fnp-8974	178	67	uniklinikum	uniklinikum	NOUN
fnp-8974	178	68	tübingen	tübingen	NOUN
fnp-8974	178	69	,	,	PUNCT
fnp-8974	178	70	tübingen	tübingen	PROPN
fnp-8974	178	71	,	,	PUNCT
fnp-8974	178	72	germany	germany	PROPN
fnp-8974	178	73	6	6	NUM
fnp-8974	178	74	german	german	ADJ
fnp-8974	178	75	center	center	NOUN
fnp-8974	178	76	for	for	ADP
fnp-8974	178	77	neurodegenerative	neurodegenerative	ADJ
fnp-8974	178	78	diseases	disease	NOUN
fnp-8974	178	79	,	,	PUNCT
fnp-8974	178	80	tübingen	tübingen	PROPN
fnp-8974	178	81	,	,	PUNCT
fnp-8974	178	82	germany	germany	PROPN
fnp-8974	178	83	tdp-43	tdp-43	PROPN
fnp-8974	178	84	is	be	AUX
fnp-8974	178	85	the	the	DET
fnp-8974	178	86	aggregating	aggregate	VERB
fnp-8974	178	87	disease	disease	NOUN
fnp-8974	178	88	protein	protein	NOUN
fnp-8974	178	89	in	in	ADP
fnp-8974	178	90	most	most	ADJ
fnp-8974	178	91	patients	patient	NOUN
fnp-8974	178	92	with	with	ADP
fnp-8974	178	93	als	al	NOUN
fnp-8974	178	94	and	and	CCONJ
fnp-8974	178	95	in	in	ADP
fnp-8974	178	96	~50	~50	NOUN
fnp-8974	178	97	 	 	SPACE
fnp-8974	178	98	%	%	NOUN
fnp-8974	178	99	of	of	ADP
fnp-8974	178	100	patients	patient	NOUN
fnp-8974	178	101	with	with	ADP
fnp-8974	178	102	ftd	ftd	PROPN
fnp-8974	178	103	.	.	PUNCT
fnp-8974	179	1	mutations	mutation	NOUN
fnp-8974	179	2	in	in	ADP
fnp-8974	179	3	the	the	DET
fnp-8974	179	4	encoding	encoding	NOUN
fnp-8974	179	5	gene	gene	NOUN
fnp-8974	179	6	tardbp	tardbp	NOUN
fnp-8974	179	7	are	be	AUX
fnp-8974	179	8	usually	usually	ADV
fnp-8974	179	9	associated	associate	VERB
fnp-8974	179	10	with	with	ADP
fnp-8974	179	11	clinical	clinical	ADJ
fnp-8974	179	12	als	al	NOUN
fnp-8974	179	13	.	.	PUNCT
fnp-8974	180	1	few	few	ADJ
fnp-8974	180	2	clinical	clinical	ADJ
fnp-8974	180	3	reports	report	NOUN
fnp-8974	180	4	describe	describe	VERB
fnp-8974	180	5	combined	combined	ADJ
fnp-8974	180	6	als	al	NOUN
fnp-8974	180	7	and	and	CCONJ
fnp-8974	180	8	ftd	ftd	PROPN
fnp-8974	180	9	or	or	CCONJ
fnp-8974	180	10	pure	pure	ADJ
fnp-8974	180	11	ftd	ftd	NOUN
fnp-8974	180	12	with	with	ADP
fnp-8974	180	13	tardbp	tardbp	NOUN
fnp-8974	180	14	mutations	mutation	NOUN
fnp-8974	180	15	;	;	PUNCT
fnp-8974	180	16	however	however	ADV
fnp-8974	180	17	,	,	PUNCT
fnp-8974	180	18	detailed	detailed	ADJ
fnp-8974	180	19	clinico	clinico	ADJ
fnp-8974	180	20	-	-	PUNCT
fnp-8974	180	21	pathological	pathological	ADJ
fnp-8974	180	22	reports	report	NOUN
fnp-8974	180	23	from	from	ADP
fnp-8974	180	24	tardbp	tardbp	NOUN
fnp-8974	180	25	mutation	mutation	NOUN
fnp-8974	180	26	carriers	carrier	NOUN
fnp-8974	180	27	are	be	AUX
fnp-8974	180	28	rare	rare	ADJ
fnp-8974	180	29	.	.	PUNCT
fnp-8974	181	1	we	we	PRON
fnp-8974	181	2	report	report	VERB
fnp-8974	181	3	a	a	DET
fnp-8974	181	4	55	55	NUM
fnp-8974	181	5	-	-	PUNCT
fnp-8974	181	6	year	year	NOUN
fnp-8974	181	7	-	-	PUNCT
fnp-8974	181	8	old	old	ADJ
fnp-8974	181	9	man	man	NOUN
fnp-8974	181	10	with	with	ADP
fnp-8974	181	11	a	a	DET
fnp-8974	181	12	tardbp	tardbp	NOUN
fnp-8974	181	13	p.m311v	p.m311v	NOUN
fnp-8974	181	14	mutation	mutation	NOUN
fnp-8974	181	15	.	.	PUNCT
fnp-8974	182	1	symptoms	symptom	NOUN
fnp-8974	182	2	started	start	VERB
fnp-8974	182	3	at	at	ADP
fnp-8974	182	4	age	age	NOUN
fnp-8974	182	5	54	54	NUM
fnp-8974	182	6	with	with	ADP
fnp-8974	182	7	impaired	impaired	ADJ
fnp-8974	182	8	naming	naming	NOUN
fnp-8974	182	9	and	and	CCONJ
fnp-8974	182	10	single	single	ADJ
fnp-8974	182	11	-	-	PUNCT
fnp-8974	182	12	word	word	NOUN
fnp-8974	182	13	comprehension	comprehension	NOUN
fnp-8974	182	14	,	,	PUNCT
fnp-8974	182	15	fulfilling	fulfil	VERB
fnp-8974	182	16	diagnostic	diagnostic	ADJ
fnp-8974	182	17	criteria	criterion	NOUN
fnp-8974	182	18	for	for	ADP
fnp-8974	182	19	semantic	semantic	ADJ
fnp-8974	182	20	variant	variant	NOUN
fnp-8974	182	21	of	of	ADP
fnp-8974	182	22	primary	primary	ADJ
fnp-8974	182	23	progressive	progressive	ADJ
fnp-8974	182	24	aphasia	aphasia	NOUN
fnp-8974	182	25	(	(	PUNCT
fnp-8974	182	26	svppa	svppa	NOUN
fnp-8974	182	27	)	)	PUNCT
fnp-8974	182	28	.	.	PUNCT
fnp-8974	183	1	about	about	ADV
fnp-8974	183	2	a	a	PRON
fnp-8974	183	3	year	year	NOUN
fnp-8974	183	4	later	later	ADV
fnp-8974	183	5	symptoms	symptom	NOUN
fnp-8974	183	6	were	be	AUX
fnp-8974	183	7	accompanied	accompany	VERB
fnp-8974	183	8	by	by	ADP
fnp-8974	183	9	behavioral	behavioral	ADJ
fnp-8974	183	10	alterations	alteration	NOUN
fnp-8974	183	11	and	and	CCONJ
fnp-8974	183	12	signs	sign	NOUN
fnp-8974	183	13	of	of	ADP
fnp-8974	183	14	motor	motor	NOUN
fnp-8974	183	15	neuron	neuron	PROPN
fnp-8974	183	16	disease	disease	PROPN
fnp-8974	183	17	.	.	PUNCT
fnp-8974	184	1	the	the	DET
fnp-8974	184	2	patient	patient	NOUN
fnp-8974	184	3	deceased	decease	VERB
fnp-8974	184	4	~18	~18	NUM
fnp-8974	184	5	months	month	NOUN
fnp-8974	184	6	after	after	SCONJ
fnp-8974	184	7	disease	disease	NOUN
fnp-8974	184	8	onset	onset	VERB
fnp-8974	184	9	.	.	PUNCT
fnp-8974	185	1	neuropathological	neuropathological	ADJ
fnp-8974	185	2	examination	examination	NOUN
fnp-8974	185	3	revealed	reveal	VERB
fnp-8974	185	4	a	a	DET
fnp-8974	185	5	severe	severe	ADJ
fnp-8974	185	6	atrophy	atrophy	NOUN
fnp-8974	185	7	of	of	ADP
fnp-8974	185	8	the	the	DET
fnp-8974	185	9	temporal	temporal	ADJ
fnp-8974	185	10	lobe	lobe	NOUN
fnp-8974	185	11	and	and	CCONJ
fnp-8974	185	12	amygdala	amygdala	VERB
fnp-8974	185	13	with	with	ADP
fnp-8974	185	14	marked	mark	VERB
fnp-8974	185	15	asymmetry	asymmetry	NOUN
fnp-8974	185	16	(	(	PUNCT
fnp-8974	185	17	left	leave	VERB
fnp-8974	185	18	 	 	SPACE
fnp-8974	185	19	>	>	SYM
fnp-8974	185	20	 	 	SPACE
fnp-8974	185	21	right	right	NOUN
fnp-8974	185	22	)	)	PUNCT
fnp-8974	185	23	.	.	PUNCT
fnp-8974	186	1	degeneration	degeneration	NOUN
fnp-8974	186	2	of	of	ADP
fnp-8974	186	3	the	the	DET
fnp-8974	186	4	primary	primary	ADJ
fnp-8974	186	5	motor	motor	NOUN
fnp-8974	186	6	system	system	NOUN
fnp-8974	186	7	was	be	AUX
fnp-8974	186	8	moderate	moderate	ADJ
fnp-8974	186	9	.	.	PUNCT
fnp-8974	187	1	pronounced	pronounce	VERB
fnp-8974	187	2	tdp-43	tdp-43	PROPN
fnp-8974	187	3	pathology	pathology	NOUN
fnp-8974	187	4	was	be	AUX
fnp-8974	187	5	observed	observe	VERB
fnp-8974	187	6	in	in	ADP
fnp-8974	187	7	these	these	DET
fnp-8974	187	8	regions	region	NOUN
fnp-8974	187	9	predominantly	predominantly	ADV
fnp-8974	187	10	as	as	ADP
fnp-8974	187	11	compact	compact	ADJ
fnp-8974	187	12	neuronal	neuronal	ADJ
fnp-8974	187	13	cytoplasmic	cytoplasmic	ADJ
fnp-8974	187	14	inclusions	inclusion	NOUN
fnp-8974	187	15	;	;	PUNCT
fnp-8974	187	16	however	however	ADV
fnp-8974	187	17	,	,	PUNCT
fnp-8974	187	18	their	their	PRON
fnp-8974	187	19	morphology	morphology	NOUN
fnp-8974	187	20	and	and	CCONJ
fnp-8974	187	21	laminar	laminar	ADJ
fnp-8974	187	22	distribution	distribution	NOUN
fnp-8974	187	23	pattern	pattern	NOUN
fnp-8974	187	24	did	do	AUX
fnp-8974	187	25	not	not	PART
fnp-8974	187	26	correspond	correspond	VERB
fnp-8974	187	27	to	to	ADP
fnp-8974	187	28	any	any	PRON
fnp-8974	187	29	of	of	ADP
fnp-8974	187	30	the	the	DET
fnp-8974	187	31	known	know	VERB
fnp-8974	187	32	ftld	ftld	ADJ
fnp-8974	187	33	-	-	PUNCT
fnp-8974	187	34	tdp	tdp	NOUN
fnp-8974	187	35	subtypes	subtype	NOUN
fnp-8974	187	36	.	.	PUNCT
fnp-8974	188	1	the	the	DET
fnp-8974	188	2	observed	observed	ADJ
fnp-8974	188	3	svppa	svppa	NOUN
fnp-8974	188	4	due	due	ADP
fnp-8974	188	5	to	to	ADP
fnp-8974	188	6	predominant	predominant	ADJ
fnp-8974	188	7	temporal	temporal	ADJ
fnp-8974	188	8	atrophy	atrophy	NOUN
fnp-8974	188	9	in	in	ADP
fnp-8974	188	10	this	this	DET
fnp-8974	188	11	p.m311v	p.m311v	ADJ
fnp-8974	188	12	patient	patient	NOUN
fnp-8974	188	13	is	be	AUX
fnp-8974	188	14	comparable	comparable	ADJ
fnp-8974	188	15	to	to	ADP
fnp-8974	188	16	reports	report	NOUN
fnp-8974	188	17	of	of	ADP
fnp-8974	188	18	two	two	NUM
fnp-8974	188	19	patients	patient	NOUN
fnp-8974	188	20	with	with	ADP
fnp-8974	188	21	a	a	DET
fnp-8974	188	22	p.i383v	p.i383v	ADJ
fnp-8974	188	23	mutation	mutation	NOUN
fnp-8974	188	24	.	.	PUNCT
fnp-8974	189	1	it	it	PRON
fnp-8974	189	2	remains	remain	VERB
fnp-8974	189	3	to	to	PART
fnp-8974	189	4	be	be	AUX
fnp-8974	189	5	seen	see	VERB
fnp-8974	189	6	,	,	PUNCT
fnp-8974	189	7	if	if	SCONJ
fnp-8974	189	8	this	this	PRON
fnp-8974	189	9	is	be	AUX
fnp-8974	189	10	a	a	DET
fnp-8974	189	11	consistent	consistent	ADJ
fnp-8974	189	12	feature	feature	NOUN
fnp-8974	189	13	of	of	ADP
fnp-8974	189	14	the	the	DET
fnp-8974	189	15	p.m311v	p.m311v	PROPN
fnp-8974	189	16	mutation	mutation	NOUN
fnp-8974	189	17	;	;	PUNCT
fnp-8974	189	18	however	however	ADV
fnp-8974	189	19	,	,	PUNCT
fnp-8974	189	20	our	our	PRON
fnp-8974	189	21	findings	finding	NOUN
fnp-8974	189	22	imply	imply	VERB
fnp-8974	189	23	that	that	SCONJ
fnp-8974	189	24	some	some	DET
fnp-8974	189	25	tardbp	tardbp	NOUN
fnp-8974	189	26	mutations	mutation	NOUN
fnp-8974	189	27	are	be	AUX
fnp-8974	189	28	associated	associate	VERB
fnp-8974	189	29	with	with	ADP
fnp-8974	189	30	a	a	DET
fnp-8974	189	31	higher	high	ADJ
fnp-8974	189	32	toxicity	toxicity	NOUN
fnp-8974	189	33	to	to	ADP
fnp-8974	189	34	neurons	neuron	NOUN
fnp-8974	189	35	in	in	ADP
fnp-8974	189	36	the	the	DET
fnp-8974	189	37	temporal	temporal	ADJ
fnp-8974	189	38	lobe	lobe	NOUN
fnp-8974	189	39	than	than	ADP
fnp-8974	189	40	to	to	ADP
fnp-8974	189	41	motor	motor	NOUN
fnp-8974	189	42	neurons	neuron	NOUN
fnp-8974	189	43	.	.	PUNCT
fnp-8974	190	1	identification	identification	NOUN
fnp-8974	190	2	of	of	ADP
fnp-8974	190	3	factors	factor	NOUN
fnp-8974	190	4	modifying	modify	VERB
fnp-8974	190	5	the	the	DET
fnp-8974	190	6	consequences	consequence	NOUN
fnp-8974	190	7	of	of	ADP
fnp-8974	190	8	tardbp	tardbp	NOUN
fnp-8974	190	9	mutations	mutation	NOUN
fnp-8974	190	10	will	will	AUX
fnp-8974	190	11	be	be	AUX
fnp-8974	190	12	crucial	crucial	ADJ
fnp-8974	190	13	for	for	ADP
fnp-8974	190	14	better	well	ADJ
fnp-8974	190	15	understanding	understanding	NOUN
fnp-8974	190	16	of	of	ADP
fnp-8974	190	17	the	the	DET
fnp-8974	190	18	pathogenesis	pathogenesis	NOUN
fnp-8974	190	19	underlying	underlie	VERB
fnp-8974	190	20	tdp-43	tdp-43	PROPN
fnp-8974	190	21	proteinopathies	proteinopathie	NOUN
fnp-8974	190	22	.	.	PUNCT
fnp-8974	191	1	vi	vi	X
fnp-8974	191	2	.	.	PUNCT
fnp-8974	191	3	neuroinflammation	neuroinflammation	NOUN
fnp-8974	191	4	p14	p14	VERB
fnp-8974	191	5	free	free	ADJ
fnp-8974	191	6	neuropathol	neuropathol	NOUN
fnp-8974	191	7	6:17:24	6:17:24	NUM
fnp-8974	191	8	borna	borna	NOUN
fnp-8974	191	9	disease	disease	NOUN
fnp-8974	191	10	virus	virus	NOUN
fnp-8974	191	11	1	1	NUM
fnp-8974	191	12	infection	infection	NOUN
fnp-8974	191	13	in	in	ADP
fnp-8974	191	14	organotypic	organotypic	ADJ
fnp-8974	191	15	hippocampal	hippocampal	ADJ
fnp-8974	191	16	slide	slide	NOUN
fnp-8974	191	17	cultures	culture	NOUN
fnp-8974	191	18	from	from	ADP
fnp-8974	191	19	adult	adult	NOUN
fnp-8974	191	20	rats	rat	NOUN
fnp-8974	191	21	maximilien	maximilien	PROPN
fnp-8974	191	22	lépine1	lépine1	PROPN
fnp-8974	191	23	,	,	PUNCT
fnp-8974	191	24	christiane	christiane	PROPN
fnp-8974	191	25	herden1	herden1	PROPN
fnp-8974	191	26	1	1	NUM
fnp-8974	191	27	institut	institut	PROPN
fnp-8974	191	28	für	für	PROPN
fnp-8974	191	29	veterinär	veterinär	PROPN
fnp-8974	191	30	-	-	PUNCT
fnp-8974	191	31	pathologie	pathologie	PROPN
fnp-8974	191	32	,	,	PUNCT
fnp-8974	191	33	justus	justus	PROPN
fnp-8974	191	34	-	-	PUNCT
fnp-8974	191	35	liebig	liebig	NOUN
fnp-8974	191	36	-	-	PUNCT
fnp-8974	191	37	university	university	NOUN
fnp-8974	191	38	giessen	giessen	NOUN
fnp-8974	191	39	,	,	PUNCT
fnp-8974	191	40	giessen	giessen	VERB
fnp-8974	191	41	,	,	PUNCT
fnp-8974	191	42	germany	germany	PROPN
fnp-8974	191	43	background	background	NOUN
fnp-8974	191	44	:	:	PUNCT
fnp-8974	191	45	borna	borna	NOUN
fnp-8974	191	46	disease	disease	NOUN
fnp-8974	191	47	virus	virus	NOUN
fnp-8974	191	48	1	1	NUM
fnp-8974	191	49	(	(	PUNCT
fnp-8974	191	50	bodv	bodv	NOUN
fnp-8974	191	51	1	1	NUM
fnp-8974	191	52	)	)	PUNCT
fnp-8974	191	53	is	be	AUX
fnp-8974	191	54	a	a	DET
fnp-8974	191	55	zoonotic	zoonotic	ADJ
fnp-8974	191	56	and	and	CCONJ
fnp-8974	191	57	neurotropic	neurotropic	ADJ
fnp-8974	191	58	virus	virus	NOUN
fnp-8974	191	59	that	that	PRON
fnp-8974	191	60	causes	cause	VERB
fnp-8974	191	61	fatal	fatal	ADJ
fnp-8974	191	62	non	non	ADJ
fnp-8974	191	63	-	-	ADJ
fnp-8974	191	64	suppurative	suppurative	ADJ
fnp-8974	191	65	encephalitis	encephalitis	NOUN
fnp-8974	191	66	in	in	ADP
fnp-8974	191	67	humans	human	NOUN
fnp-8974	191	68	,	,	PUNCT
fnp-8974	191	69	horses	horse	NOUN
fnp-8974	191	70	,	,	PUNCT
fnp-8974	191	71	sheep	sheep	NOUN
fnp-8974	191	72	,	,	PUNCT
fnp-8974	191	73	and	and	CCONJ
fnp-8974	191	74	alpacas	alpaca	NOUN
fnp-8974	191	75	.	.	PUNCT
fnp-8974	192	1	the	the	DET
fnp-8974	192	2	white	white	ADV
fnp-8974	192	3	-	-	PUNCT
fnp-8974	192	4	toothed	toothed	ADJ
fnp-8974	192	5	shrew	shrew	NOUN
fnp-8974	192	6	(	(	PUNCT
fnp-8974	192	7	crocidura	crocidura	NOUN
fnp-8974	192	8	leucodon	leucodon	NOUN
fnp-8974	192	9	)	)	PUNCT
fnp-8974	192	10	has	have	AUX
fnp-8974	192	11	been	be	AUX
fnp-8974	192	12	identified	identify	VERB
fnp-8974	192	13	as	as	ADP
fnp-8974	192	14	a	a	DET
fnp-8974	192	15	natural	natural	ADJ
fnp-8974	192	16	reservoir	reservoir	NOUN
fnp-8974	192	17	host	host	NOUN
fnp-8974	192	18	,	,	PUNCT
fnp-8974	192	19	harboring	harbor	VERB
fnp-8974	192	20	a	a	DET
fnp-8974	192	21	persistent	persistent	ADJ
fnp-8974	192	22	infection	infection	NOUN
fnp-8974	192	23	without	without	ADP
fnp-8974	192	24	developing	develop	VERB
fnp-8974	192	25	neurological	neurological	ADJ
fnp-8974	192	26	impairments	impairment	NOUN
fnp-8974	192	27	.	.	PUNCT
fnp-8974	193	1	for	for	ADP
fnp-8974	193	2	infection	infection	NOUN
fnp-8974	193	3	studies	study	NOUN
fnp-8974	193	4	,	,	PUNCT
fnp-8974	193	5	the	the	DET
fnp-8974	193	6	adult	adult	NOUN
fnp-8974	193	7	rat	rat	NOUN
fnp-8974	193	8	serves	serve	VERB
fnp-8974	193	9	as	as	ADP
fnp-8974	193	10	a	a	DET
fnp-8974	193	11	suitable	suitable	ADJ
fnp-8974	193	12	model	model	NOUN
fnp-8974	193	13	for	for	ADP
fnp-8974	193	14	studying	study	VERB
fnp-8974	193	15	inflammation	inflammation	NOUN
fnp-8974	193	16	in	in	ADP
fnp-8974	193	17	dead	dead	ADJ
fnp-8974	193	18	-	-	PUNCT
fnp-8974	193	19	end	end	NOUN
fnp-8974	193	20	hosts	host	NOUN
fnp-8974	193	21	.	.	PUNCT
fnp-8974	194	1	method(s	method(	VERB
fnp-8974	194	2	):	):	PUNCT
fnp-8974	194	3	viability	viability	NOUN
fnp-8974	194	4	of	of	ADP
fnp-8974	194	5	organotypic	organotypic	ADJ
fnp-8974	194	6	hippocampal	hippocampal	ADJ
fnp-8974	194	7	slice	slice	NOUN
fnp-8974	194	8	cultures	culture	NOUN
fnp-8974	194	9	of	of	ADP
fnp-8974	194	10	adult	adult	NOUN
fnp-8974	194	11	rats	rat	NOUN
fnp-8974	194	12	was	be	AUX
fnp-8974	194	13	analyzed	analyze	VERB
fnp-8974	194	14	by	by	ADP
fnp-8974	194	15	lve	lve	NOUN
fnp-8974	194	16	/	/	SYM
fnp-8974	194	17	dead	dead	ADJ
fnp-8974	194	18	immunofluoresence	immunofluoresence	NOUN
fnp-8974	194	19	staining	stain	VERB
fnp-8974	194	20	,	,	PUNCT
fnp-8974	194	21	ldh	ldh	PROPN
fnp-8974	194	22	assay	assay	PROPN
fnp-8974	194	23	,	,	PUNCT
fnp-8974	194	24	pcr	pcr	NOUN
fnp-8974	194	25	of	of	ADP
fnp-8974	194	26	housekeeping	housekeeping	NOUN
fnp-8974	194	27	genes	gene	NOUN
fnp-8974	194	28	and	and	CCONJ
fnp-8974	194	29	morphologic	morphologic	ADJ
fnp-8974	194	30	integrity	integrity	NOUN
fnp-8974	194	31	.	.	PUNCT
fnp-8974	195	1	in	in	ADP
fnp-8974	195	2	a	a	DET
fnp-8974	195	3	second	second	ADJ
fnp-8974	195	4	step	step	NOUN
fnp-8974	195	5	,	,	PUNCT
fnp-8974	195	6	viral	viral	ADJ
fnp-8974	195	7	spread	spread	NOUN
fnp-8974	195	8	,	,	PUNCT
fnp-8974	195	9	infection	infection	NOUN
fnp-8974	195	10	patterns	pattern	NOUN
fnp-8974	195	11	,	,	PUNCT
fnp-8974	195	12	and	and	CCONJ
fnp-8974	195	13	the	the	DET
fnp-8974	195	14	local	local	ADJ
fnp-8974	195	15	innate	innate	ADJ
fnp-8974	195	16	immune	immune	ADJ
fnp-8974	195	17	response	response	NOUN
fnp-8974	195	18	were	be	AUX
fnp-8974	195	19	analyzed	analyze	VERB
fnp-8974	195	20	using	use	VERB
fnp-8974	195	21	immunofluorescence	immunofluorescence	NOUN
fnp-8974	195	22	and	and	CCONJ
fnp-8974	195	23	qpcr	qpcr	ADV
fnp-8974	195	24	to	to	PART
fnp-8974	195	25	assess	assess	VERB
fnp-8974	195	26	viral	viral	ADJ
fnp-8974	195	27	load	load	NOUN
fnp-8974	195	28	.	.	PUNCT
fnp-8974	196	1	result(s	result(s	NOUN
fnp-8974	196	2	):	):	PUNCT
fnp-8974	196	3	ohcs	ohc	NOUN
fnp-8974	196	4	were	be	AUX
fnp-8974	196	5	susceptible	susceptible	ADJ
fnp-8974	196	6	to	to	ADP
fnp-8974	196	7	infection	infection	NOUN
fnp-8974	196	8	while	while	SCONJ
fnp-8974	196	9	maintaining	maintain	VERB
fnp-8974	196	10	tissue	tissue	NOUN
fnp-8974	196	11	integrity	integrity	NOUN
fnp-8974	196	12	for	for	ADP
fnp-8974	196	13	up	up	ADP
fnp-8974	196	14	to	to	PART
fnp-8974	196	15	28	28	NUM
fnp-8974	196	16	days	day	NOUN
fnp-8974	196	17	in	in	ADP
fnp-8974	196	18	culture	culture	NOUN
fnp-8974	196	19	.	.	PUNCT
fnp-8974	197	1	viral	viral	ADJ
fnp-8974	197	2	distribution	distribution	NOUN
fnp-8974	197	3	was	be	AUX
fnp-8974	197	4	uniform	uniform	ADJ
fnp-8974	197	5	across	across	ADP
fnp-8974	197	6	hippocampal	hippocampal	ADJ
fnp-8974	197	7	regions	region	NOUN
fnp-8974	197	8	,	,	PUNCT
fnp-8974	197	9	but	but	CCONJ
fnp-8974	197	10	viral	viral	ADJ
fnp-8974	197	11	load	load	NOUN
fnp-8974	197	12	decreased	decrease	VERB
fnp-8974	197	13	between	between	ADP
fnp-8974	197	14	days	day	NOUN
fnp-8974	197	15	3	3	NUM
fnp-8974	197	16	and	and	CCONJ
fnp-8974	197	17	7	7	NUM
fnp-8974	197	18	post	post	NOUN
fnp-8974	197	19	-	-	ADJ
fnp-8974	197	20	infection	infection	ADJ
fnp-8974	197	21	(	(	PUNCT
fnp-8974	197	22	p.i	p.i	PROPN
fnp-8974	197	23	.	.	PUNCT
fnp-8974	197	24	)	)	PUNCT
fnp-8974	198	1	before	before	ADP
fnp-8974	198	2	increasing	increase	VERB
fnp-8974	198	3	between	between	ADP
fnp-8974	198	4	days	day	NOUN
fnp-8974	198	5	7	7	NUM
fnp-8974	198	6	and	and	CCONJ
fnp-8974	198	7	21	21	NUM
fnp-8974	198	8	p.i	p.i	PROPN
fnp-8974	198	9	.	.	PUNCT
fnp-8974	198	10	conclusion(s	conclusion(s	NOUN
fnp-8974	198	11	):	):	PUNCT
fnp-8974	198	12	these	these	DET
fnp-8974	198	13	results	result	NOUN
fnp-8974	198	14	demonstrate	demonstrate	VERB
fnp-8974	198	15	that	that	DET
fnp-8974	198	16	ohcs	ohc	NOUN
fnp-8974	198	17	provide	provide	VERB
fnp-8974	198	18	a	a	DET
fnp-8974	198	19	valuable	valuable	ADJ
fnp-8974	198	20	model	model	NOUN
fnp-8974	198	21	for	for	ADP
fnp-8974	198	22	studying	study	VERB
fnp-8974	198	23	viral	viral	ADJ
fnp-8974	198	24	persistence	persistence	NOUN
fnp-8974	198	25	,	,	PUNCT
fnp-8974	198	26	distribution	distribution	NOUN
fnp-8974	198	27	,	,	PUNCT
fnp-8974	198	28	and	and	CCONJ
fnp-8974	198	29	load	load	NOUN
fnp-8974	198	30	in	in	ADP
fnp-8974	198	31	adult	adult	NOUN
fnp-8974	198	32	rats	rat	NOUN
fnp-8974	198	33	.	.	PUNCT
fnp-8974	199	1	p15	p15	ADJ
fnp-8974	199	2	free	free	ADJ
fnp-8974	199	3	neuropathol	neuropathol	NOUN
fnp-8974	199	4	6:17:25	6:17:25	NUM
fnp-8974	199	5	immune	immune	ADJ
fnp-8974	199	6	profile	profile	NOUN
fnp-8974	199	7	and	and	CCONJ
fnp-8974	199	8	clinical	clinical	ADJ
fnp-8974	199	9	characteristics	characteristic	NOUN
fnp-8974	199	10	of	of	ADP
fnp-8974	199	11	central	central	ADJ
fnp-8974	199	12	nervous	nervous	ADJ
fnp-8974	199	13	system	system	NOUN
fnp-8974	199	14	graft	graft	NOUN
fnp-8974	199	15	-	-	PUNCT
fnp-8974	199	16	versus	versus	ADP
fnp-8974	199	17	-	-	PUNCT
fnp-8974	199	18	host	host	NOUN
fnp-8974	199	19	-	-	PUNCT
fnp-8974	199	20	disease	disease	NOUN
fnp-8974	199	21	ida	ida	PROPN
fnp-8974	199	22	vogt1	vogt1	PROPN
fnp-8974	199	23	,	,	PUNCT
fnp-8974	199	24	benedikt	benedikt	PROPN
fnp-8974	199	25	sauer1	sauer1	PROPN
fnp-8974	199	26	,	,	PUNCT
fnp-8974	199	27	dorothea	dorothea	PROPN
fnp-8974	199	28	münch2	münch2	PROPN
fnp-8974	199	29	,	,	PUNCT
fnp-8974	199	30	salem	salem	PROPN
fnp-8974	199	31	ajib3	ajib3	PROPN
fnp-8974	199	32	,	,	PUNCT
fnp-8974	199	33	katharina	katharina	PROPN
fnp-8974	199	34	wenger	wenger	PROPN
fnp-8974	199	35	-	-	PUNCT
fnp-8974	199	36	alakmeh4,5,6,7	alakmeh4,5,6,7	NOUN
fnp-8974	199	37	,	,	PUNCT
fnp-8974	199	38	svenja	svenja	NOUN
fnp-8974	199	39	klinsing1	klinsing1	PROPN
fnp-8974	199	40	,	,	PUNCT
fnp-8974	199	41	patrick	patrick	PROPN
fnp-8974	199	42	n.	n.	PROPN
fnp-8974	199	43	harter8	harter8	PROPN
fnp-8974	199	44	,	,	PUNCT
fnp-8974	199	45	hildegard	hildegard	PROPN
fnp-8974	199	46	dohmen9	dohmen9	PROPN
fnp-8974	199	47	,	,	PUNCT
fnp-8974	199	48	till	till	SCONJ
fnp-8974	199	49	acker9	acker9	PROPN
fnp-8974	199	50	,	,	PUNCT
fnp-8974	199	51	martina	martina	PROPN
fnp-8974	199	52	deckert10	deckert10	PROPN
fnp-8974	199	53	,	,	PUNCT
fnp-8974	199	54	karl	karl	PROPN
fnp-8974	199	55	heinz	heinz	PROPN
fnp-8974	199	56	plate2,4,5	plate2,4,5	PROPN
fnp-8974	199	57	,	,	PUNCT
fnp-8974	199	58	christine	christine	PROPN
fnp-8974	199	59	stadelmann	stadelmann	PROPN
fnp-8974	199	60	-	-	PUNCT
fnp-8974	199	61	nessler11	nessler11	PROPN
fnp-8974	199	62	,	,	PUNCT
fnp-8974	199	63	joachim	joachim	PROPN
fnp-8974	199	64	p.	p.	PROPN
fnp-8974	199	65	steinbach1,4,5	steinbach1,4,5	PROPN
fnp-8974	199	66	,	,	PUNCT
fnp-8974	199	67	werner	werner	PROPN
fnp-8974	199	68	stenzel12	stenzel12	NOUN
fnp-8974	199	69	,	,	PUNCT
fnp-8974	199	70	katharina	katharina	PROPN
fnp-8974	199	71	j.	j.	PROPN
fnp-8974	199	72	weber2,4,5,6	weber2,4,5,6	PROPN
fnp-8974	199	73	,	,	PUNCT
fnp-8974	199	74	pia	pia	PROPN
fnp-8974	199	75	zeiner1,4,5,6	zeiner1,4,5,6	NUM
fnp-8974	199	76	1	1	NUM
fnp-8974	199	77	department	department	NOUN
fnp-8974	199	78	of	of	ADP
fnp-8974	199	79	neurology	neurology	NOUN
fnp-8974	199	80	,	,	PUNCT
fnp-8974	199	81	dr	dr	PROPN
fnp-8974	199	82	.	.	PROPN
fnp-8974	199	83	senckenberg	senckenberg	PROPN
fnp-8974	199	84	institute	institute	PROPN
fnp-8974	199	85	of	of	ADP
fnp-8974	199	86	neurooncology	neurooncology	PROPN
fnp-8974	199	87	,	,	PUNCT
fnp-8974	199	88	university	university	NOUN
fnp-8974	199	89	hospital	hospital	NOUN
fnp-8974	199	90	frankfurt	frankfurt	PROPN
fnp-8974	199	91	,	,	PUNCT
fnp-8974	199	92	goethe	goethe	PROPN
fnp-8974	199	93	university	university	PROPN
fnp-8974	199	94	,	,	PUNCT
fnp-8974	199	95	frankfurt	frankfurt	PROPN
fnp-8974	199	96	am	be	AUX
fnp-8974	199	97	main	main	ADJ
fnp-8974	199	98	,	,	PUNCT
fnp-8974	199	99	germany	germany	PROPN
fnp-8974	199	100	2	2	NUM
fnp-8974	199	101	edinger	edinger	PROPN
fnp-8974	199	102	institute	institute	NOUN
fnp-8974	199	103	,	,	PUNCT
fnp-8974	199	104	university	university	NOUN
fnp-8974	199	105	hospital	hospital	NOUN
fnp-8974	199	106	frankfurt	frankfurt	PROPN
fnp-8974	199	107	,	,	PUNCT
fnp-8974	199	108	goethe	goethe	PROPN
fnp-8974	199	109	university	university	PROPN
fnp-8974	199	110	,	,	PUNCT
fnp-8974	199	111	frankfurt	frankfurt	PROPN
fnp-8974	199	112	am	be	AUX
fnp-8974	199	113	main	main	ADJ
fnp-8974	199	114	,	,	PUNCT
fnp-8974	199	115	germany	germany	PROPN
fnp-8974	199	116	3	3	NUM
fnp-8974	199	117	department	department	NOUN
fnp-8974	199	118	of	of	ADP
fnp-8974	199	119	medicine	medicine	NOUN
fnp-8974	199	120	,	,	PUNCT
fnp-8974	199	121	hematology	hematology	NOUN
fnp-8974	199	122	and	and	CCONJ
fnp-8974	199	123	oncology	oncology	NOUN
fnp-8974	199	124	,	,	PUNCT
fnp-8974	199	125	university	university	NOUN
fnp-8974	199	126	hospital	hospital	NOUN
fnp-8974	199	127	frankfurt	frankfurt	PROPN
fnp-8974	199	128	,	,	PUNCT
fnp-8974	199	129	goethe	goethe	PROPN
fnp-8974	199	130	university	university	PROPN
fnp-8974	199	131	,	,	PUNCT
fnp-8974	199	132	frankfurt	frankfurt	PROPN
fnp-8974	199	133	am	be	AUX
fnp-8974	199	134	main	main	ADJ
fnp-8974	199	135	,	,	PUNCT
fnp-8974	199	136	germany	germany	NOUN
fnp-8974	199	137	4	4	NUM
fnp-8974	199	138	german	german	ADJ
fnp-8974	199	139	cancer	cancer	NOUN
fnp-8974	199	140	research	research	NOUN
fnp-8974	199	141	center	center	NOUN
fnp-8974	199	142	(	(	PUNCT
fnp-8974	199	143	dkfz	dkfz	ADJ
fnp-8974	199	144	)	)	PUNCT
fnp-8974	199	145	heidelberg	heidelberg	PROPN
fnp-8974	199	146	,	,	PUNCT
fnp-8974	199	147	germany	germany	PROPN
fnp-8974	199	148	;	;	PUNCT
fnp-8974	199	149	german	german	ADJ
fnp-8974	199	150	cancer	cancer	NOUN
fnp-8974	199	151	consortium	consortium	NOUN
fnp-8974	199	152	(	(	PUNCT
fnp-8974	199	153	dktk	dktk	NOUN
fnp-8974	199	154	)	)	PUNCT
fnp-8974	199	155	,	,	PUNCT
fnp-8974	199	156	frankfurt	frankfurt	PROPN
fnp-8974	199	157	am	be	AUX
fnp-8974	199	158	main	main	ADJ
fnp-8974	199	159	,	,	PUNCT
fnp-8974	199	160	germany	germany	PROPN
fnp-8974	199	161	5	5	NUM
fnp-8974	199	162	frankfurt	frankfurt	PROPN
fnp-8974	199	163	cancer	cancer	PROPN
fnp-8974	199	164	institute	institute	PROPN
fnp-8974	199	165	(	(	PUNCT
fnp-8974	199	166	fci	fci	PROPN
fnp-8974	199	167	)	)	PUNCT
fnp-8974	199	168	,	,	PUNCT
fnp-8974	199	169	goethe	goethe	PROPN
fnp-8974	199	170	university	university	PROPN
fnp-8974	199	171	frankfurt	frankfurt	PROPN
fnp-8974	199	172	,	,	PUNCT
fnp-8974	199	173	frankfurt	frankfurt	PROPN
fnp-8974	199	174	am	be	AUX
fnp-8974	199	175	main	main	ADJ
fnp-8974	199	176	,	,	PUNCT
fnp-8974	199	177	germany	germany	PROPN
fnp-8974	199	178	6	6	NUM
fnp-8974	199	179	mildred	mildred	PROPN
fnp-8974	199	180	-	-	PUNCT
fnp-8974	199	181	scheelnachwuchszentrum	scheelnachwuchszentrum	NOUN
fnp-8974	199	182	,	,	PUNCT
fnp-8974	199	183	goethe	goethe	PROPN
fnp-8974	199	184	university	university	PROPN
fnp-8974	199	185	,	,	PUNCT
fnp-8974	199	186	frankfurt	frankfurt	PROPN
fnp-8974	199	187	am	be	AUX
fnp-8974	199	188	main	main	ADJ
fnp-8974	199	189	,	,	PUNCT
fnp-8974	199	190	germany	germany	PROPN
fnp-8974	199	191	7	7	NUM
fnp-8974	199	192	institute	institute	PROPN
fnp-8974	199	193	of	of	ADP
fnp-8974	199	194	neuroradiology	neuroradiology	NOUN
fnp-8974	199	195	,	,	PUNCT
fnp-8974	199	196	university	university	NOUN
fnp-8974	199	197	hospital	hospital	NOUN
fnp-8974	199	198	frankfurt	frankfurt	PROPN
fnp-8974	199	199	,	,	PUNCT
fnp-8974	199	200	goethe	goethe	PROPN
fnp-8974	199	201	university	university	PROPN
fnp-8974	199	202	,	,	PUNCT
fnp-8974	199	203	frankfurt	frankfurt	PROPN
fnp-8974	199	204	am	be	AUX
fnp-8974	199	205	main	main	ADJ
fnp-8974	199	206	,	,	PUNCT
fnp-8974	199	207	germany	germany	PROPN
fnp-8974	199	208	8	8	NUM
fnp-8974	199	209	center	center	NOUN
fnp-8974	199	210	for	for	ADP
fnp-8974	199	211	neuropathology	neuropathology	NOUN
fnp-8974	199	212	and	and	CCONJ
fnp-8974	199	213	prion	prion	NOUN
fnp-8974	199	214	research	research	NOUN
fnp-8974	199	215	,	,	PUNCT
fnp-8974	199	216	faculty	faculty	NOUN
fnp-8974	199	217	of	of	ADP
fnp-8974	199	218	medicine	medicine	NOUN
fnp-8974	199	219	,	,	PUNCT
fnp-8974	199	220	lmu	lmu	PROPN
fnp-8974	199	221	munich	munich	PROPN
fnp-8974	199	222	,	,	PUNCT
fnp-8974	199	223	munich	munich	PROPN
fnp-8974	199	224	,	,	PUNCT
fnp-8974	199	225	germany	germany	PROPN
fnp-8974	199	226	9	9	NUM
fnp-8974	199	227	institute	institute	PROPN
fnp-8974	199	228	of	of	ADP
fnp-8974	199	229	neuropathology	neuropathology	NOUN
fnp-8974	199	230	,	,	PUNCT
fnp-8974	199	231	justus.liebig	justus.liebig	PROPN
fnp-8974	199	232	-	-	PUNCT
fnp-8974	199	233	university	university	NOUN
fnp-8974	199	234	giessen	giessen	NOUN
fnp-8974	199	235	,	,	PUNCT
fnp-8974	199	236	giessen	giessen	VERB
fnp-8974	199	237	,	,	PUNCT
fnp-8974	199	238	germany	germany	PROPN
fnp-8974	199	239	10	10	NUM
fnp-8974	199	240	institute	institute	PROPN
fnp-8974	199	241	of	of	ADP
fnp-8974	199	242	neuropathology	neuropathology	NOUN
fnp-8974	199	243	,	,	PUNCT
fnp-8974	199	244	university	university	NOUN
fnp-8974	199	245	hospital	hospital	NOUN
fnp-8974	199	246	düsseldorf	düsseldorf	PROPN
fnp-8974	199	247	and	and	CCONJ
fnp-8974	199	248	medical	medical	ADJ
fnp-8974	199	249	faculty	faculty	NOUN
fnp-8974	199	250	,	,	PUNCT
fnp-8974	199	251	heinrich	heinrich	PROPN
fnp-8974	199	252	heine	heine	PROPN
fnp-8974	199	253	university	university	PROPN
fnp-8974	199	254	düsseldorf	düsseldorf	PROPN
fnp-8974	199	255	,	,	PUNCT
fnp-8974	199	256	germany	germany	PROPN
fnp-8974	199	257	11	11	NUM
fnp-8974	199	258	insitute	insitute	NOUN
fnp-8974	199	259	of	of	ADP
fnp-8974	199	260	neuropathology	neuropathology	NOUN
fnp-8974	199	261	,	,	PUNCT
fnp-8974	199	262	university	university	NOUN
fnp-8974	199	263	medical	medical	ADJ
fnp-8974	199	264	center	center	NOUN
fnp-8974	199	265	,	,	PUNCT
fnp-8974	199	266	georg	georg	PROPN
fnp-8974	199	267	august	august	PROPN
fnp-8974	199	268	university	university	PROPN
fnp-8974	199	269	,	,	PUNCT
fnp-8974	199	270	göttingen	göttingen	NOUN
fnp-8974	199	271	,	,	PUNCT
fnp-8974	199	272	germany	germany	PROPN
fnp-8974	199	273	12	12	NUM
fnp-8974	199	274	department	department	NOUN
fnp-8974	199	275	of	of	ADP
fnp-8974	199	276	neuropathology	neuropathology	NOUN
fnp-8974	199	277	,	,	PUNCT
fnp-8974	199	278	charité	charité	PROPN
fnp-8974	199	279	–	–	PUNCT
fnp-8974	199	280	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	199	281	berlin	berlin	PROPN
fnp-8974	199	282	,	,	PUNCT
fnp-8974	199	283	corporate	corporate	ADJ
fnp-8974	199	284	member	member	NOUN
fnp-8974	199	285	of	of	ADP
fnp-8974	199	286	freie	freie	PROPN
fnp-8974	199	287	universität	universität	PROPN
fnp-8974	199	288	berlin	berlin	PROPN
fnp-8974	199	289	und	und	PROPN
fnp-8974	199	290	humboldt	humboldt	PROPN
fnp-8974	199	291	-	-	PUNCT
fnp-8974	199	292	universität	universität	PROPN
fnp-8974	199	293	zu	zu	PROPN
fnp-8974	199	294	berlin	berlin	PROPN
fnp-8974	199	295	,	,	PUNCT
fnp-8974	199	296	berlin	berlin	PROPN
fnp-8974	199	297	,	,	PUNCT
fnp-8974	199	298	germany	germany	PROPN
fnp-8974	199	299	background	background	NOUN
fnp-8974	199	300	:	:	PUNCT
fnp-8974	199	301	central	central	ADJ
fnp-8974	199	302	nervous	nervous	ADJ
fnp-8974	199	303	system	system	NOUN
fnp-8974	199	304	graft	graft	NOUN
fnp-8974	199	305	-	-	PUNCT
fnp-8974	199	306	versus	versus	ADP
fnp-8974	199	307	-	-	PUNCT
fnp-8974	199	308	host	host	NOUN
fnp-8974	199	309	disease	disease	NOUN
fnp-8974	199	310	(	(	PUNCT
fnp-8974	199	311	cns	cns	NOUN
fnp-8974	199	312	-	-	PUNCT
fnp-8974	199	313	gvhd	gvhd	NOUN
fnp-8974	199	314	)	)	PUNCT
fnp-8974	199	315	is	be	AUX
fnp-8974	199	316	a	a	DET
fnp-8974	199	317	rare	rare	ADJ
fnp-8974	199	318	complication	complication	NOUN
fnp-8974	199	319	following	follow	VERB
fnp-8974	199	320	allogeneic	allogeneic	ADJ
fnp-8974	199	321	hematopoietic	hematopoietic	ADJ
fnp-8974	199	322	stem	stem	NOUN
fnp-8974	199	323	cell	cell	NOUN
fnp-8974	199	324	transplantation	transplantation	NOUN
fnp-8974	199	325	(	(	PUNCT
fnp-8974	199	326	allo	allo	NOUN
fnp-8974	199	327	-	-	PUNCT
fnp-8974	199	328	hsct	hsct	PROPN
fnp-8974	199	329	)	)	PUNCT
fnp-8974	199	330	.	.	PUNCT
fnp-8974	200	1	early	early	ADJ
fnp-8974	200	2	diagnosis	diagnosis	NOUN
fnp-8974	200	3	and	and	CCONJ
fnp-8974	200	4	treatment	treatment	NOUN
fnp-8974	200	5	are	be	AUX
fnp-8974	200	6	essential	essential	ADJ
fnp-8974	200	7	to	to	PART
fnp-8974	200	8	halt	halt	VERB
fnp-8974	200	9	disease	disease	NOUN
fnp-8974	200	10	progression	progression	NOUN
fnp-8974	200	11	.	.	PUNCT
fnp-8974	201	1	data	datum	NOUN
fnp-8974	201	2	on	on	ADP
fnp-8974	201	3	risk	risk	NOUN
fnp-8974	201	4	factors	factor	NOUN
fnp-8974	201	5	,	,	PUNCT
fnp-8974	201	6	disease	disease	NOUN
fnp-8974	201	7	mechanisms	mechanism	NOUN
fnp-8974	201	8	and	and	CCONJ
fnp-8974	201	9	treatment	treatment	NOUN
fnp-8974	201	10	is	be	AUX
fnp-8974	201	11	scarce	scarce	ADJ
fnp-8974	201	12	.	.	PUNCT
fnp-8974	202	1	while	while	SCONJ
fnp-8974	202	2	clinical	clinical	ADJ
fnp-8974	202	3	criteria	criterion	NOUN
fnp-8974	202	4	have	have	AUX
fnp-8974	202	5	been	be	AUX
fnp-8974	202	6	suggested	suggest	VERB
fnp-8974	202	7	,	,	PUNCT
fnp-8974	202	8	histopathological	histopathological	ADJ
fnp-8974	202	9	criteria	criterion	NOUN
fnp-8974	202	10	are	be	AUX
fnp-8974	202	11	lacking	lack	VERB
fnp-8974	202	12	.	.	PUNCT
fnp-8974	203	1	objective(s	objective(s	NOUN
fnp-8974	203	2	):	):	PUNCT
fnp-8974	203	3	this	this	DET
fnp-8974	203	4	project	project	NOUN
fnp-8974	203	5	aims	aim	VERB
fnp-8974	203	6	to	to	PART
fnp-8974	203	7	assess	assess	VERB
fnp-8974	203	8	frequency	frequency	NOUN
fnp-8974	203	9	,	,	PUNCT
fnp-8974	203	10	clinical	clinical	ADJ
fnp-8974	203	11	features	feature	NOUN
fnp-8974	203	12	and	and	CCONJ
fnp-8974	203	13	histopathological	histopathological	ADJ
fnp-8974	203	14	findings	finding	NOUN
fnp-8974	203	15	to	to	PART
fnp-8974	203	16	improve	improve	VERB
fnp-8974	203	17	our	our	PRON
fnp-8974	203	18	understanding	understanding	NOUN
fnp-8974	203	19	of	of	ADP
fnp-8974	203	20	its	its	PRON
fnp-8974	203	21	immune	immune	ADJ
fnp-8974	203	22	microenvironment	microenvironment	NOUN
fnp-8974	203	23	.	.	PUNCT
fnp-8974	204	1	question(s	question(s	PROPN
fnp-8974	204	2	):	):	PUNCT
fnp-8974	204	3	1	1	X
fnp-8974	204	4	.	.	X
fnp-8974	204	5	is	be	AUX
fnp-8974	204	6	cns	cns	NOUN
fnp-8974	204	7	-	-	PUNCT
fnp-8974	204	8	gvhd	gvhd	NOUN
fnp-8974	204	9	a	a	DET
fnp-8974	204	10	clinically	clinically	ADV
fnp-8974	204	11	significant	significant	ADJ
fnp-8974	204	12	complication	complication	NOUN
fnp-8974	204	13	in	in	ADP
fnp-8974	204	14	allo	allo	PROPN
fnp-8974	204	15	-	-	PUNCT
fnp-8974	204	16	hsct	hsct	NOUN
fnp-8974	204	17	patients	patient	NOUN
fnp-8974	204	18	?	?	PUNCT
fnp-8974	205	1	2	2	X
fnp-8974	205	2	.	.	X
fnp-8974	205	3	what	what	PRON
fnp-8974	205	4	insights	insight	NOUN
fnp-8974	205	5	do	do	VERB
fnp-8974	205	6	cns	cns	NOUN
fnp-8974	205	7	-	-	PUNCT
fnp-8974	205	8	gvhd	gvhd	NOUN
fnp-8974	205	9	biopsies	biopsy	NOUN
fnp-8974	205	10	reveal	reveal	VERB
fnp-8974	205	11	?	?	PUNCT
fnp-8974	206	1	3	3	X
fnp-8974	206	2	.	.	X
fnp-8974	206	3	can	can	AUX
fnp-8974	206	4	cns	cns	VERB
fnp-8974	206	5	-	-	PUNCT
fnp-8974	206	6	gvhd	gvhd	NOUN
fnp-8974	206	7	diagnosis	diagnosis	NOUN
fnp-8974	206	8	criteria	criterion	NOUN
fnp-8974	206	9	be	be	AUX
fnp-8974	206	10	improved	improve	VERB
fnp-8974	206	11	?	?	PUNCT
fnp-8974	207	1	method(s	method(	VERB
fnp-8974	207	2	):	):	PUNCT
fnp-8974	207	3	1436	1436	NUM
fnp-8974	207	4	patients	patient	NOUN
fnp-8974	207	5	treated	treat	VERB
fnp-8974	207	6	with	with	ADP
fnp-8974	207	7	hsct	hsct	NOUN
fnp-8974	207	8	at	at	ADP
fnp-8974	207	9	the	the	DET
fnp-8974	207	10	university	university	NOUN
fnp-8974	207	11	hospital	hospital	NOUN
fnp-8974	207	12	frankfurt	frankfurt	PROPN
fnp-8974	207	13	between	between	ADP
fnp-8974	207	14	01.01.2014	01.01.2014	PRON
fnp-8974	207	15	and	and	CCONJ
fnp-8974	207	16	31.07.2024	31.07.2024	NUM
fnp-8974	207	17	were	be	AUX
fnp-8974	207	18	retrospectively	retrospectively	ADV
fnp-8974	207	19	examined	examine	VERB
fnp-8974	207	20	for	for	ADP
fnp-8974	207	21	cns	cns	NOUN
fnp-8974	207	22	-	-	PUNCT
fnp-8974	207	23	gvhd	gvhd	NOUN
fnp-8974	207	24	,	,	PUNCT
fnp-8974	207	25	risk	risk	NOUN
fnp-8974	207	26	factors	factor	NOUN
fnp-8974	207	27	and	and	CCONJ
fnp-8974	207	28	outcomes	outcome	NOUN
fnp-8974	207	29	.	.	PUNCT
fnp-8974	208	1	in	in	ADP
fnp-8974	208	2	an	an	DET
fnp-8974	208	3	additional	additional	ADJ
fnp-8974	208	4	multicenter	multicenter	ADJ
fnp-8974	208	5	cns	cns	NOUN
fnp-8974	208	6	-	-	PUNCT
fnp-8974	208	7	gvhd	gvhd	NOUN
fnp-8974	208	8	cohort	cohort	NOUN
fnp-8974	208	9	of	of	ADP
fnp-8974	208	10	7	7	NUM
fnp-8974	208	11	biopsied	biopsied	ADJ
fnp-8974	208	12	patients	patient	NOUN
fnp-8974	208	13	,	,	PUNCT
fnp-8974	208	14	intensity	intensity	NOUN
fnp-8974	208	15	,	,	PUNCT
fnp-8974	208	16	localization	localization	NOUN
fnp-8974	208	17	,	,	PUNCT
fnp-8974	208	18	cellular	cellular	ADJ
fnp-8974	208	19	composition	composition	NOUN
fnp-8974	208	20	of	of	ADP
fnp-8974	208	21	inflammation	inflammation	NOUN
fnp-8974	208	22	,	,	PUNCT
fnp-8974	208	23	necrosis	necrosis	NOUN
fnp-8974	208	24	and	and	CCONJ
fnp-8974	208	25	gliosis	gliosis	NOUN
fnp-8974	208	26	were	be	AUX
fnp-8974	208	27	assessed	assess	VERB
fnp-8974	208	28	.	.	PUNCT
fnp-8974	209	1	result(s	result(s	PROPN
fnp-8974	209	2	):	):	PUNCT
fnp-8974	209	3	of	of	ADP
fnp-8974	209	4	1436	1436	NUM
fnp-8974	209	5	hsct	hsct	NOUN
fnp-8974	209	6	patients	patient	NOUN
fnp-8974	209	7	,	,	PUNCT
fnp-8974	209	8	786	786	NUM
fnp-8974	209	9	received	receive	VERB
fnp-8974	209	10	their	their	PRON
fnp-8974	209	11	first	first	ADJ
fnp-8974	209	12	allo	allo	PROPN
fnp-8974	209	13	-	-	PUNCT
fnp-8974	209	14	hsct	hsct	NOUN
fnp-8974	209	15	.	.	PUNCT
fnp-8974	210	1	among	among	ADP
fnp-8974	210	2	those	those	PRON
fnp-8974	210	3	,	,	PUNCT
fnp-8974	210	4	5	5	NUM
fnp-8974	210	5	patients	patient	NOUN
fnp-8974	210	6	were	be	AUX
fnp-8974	210	7	diagnosed	diagnose	VERB
fnp-8974	210	8	with	with	ADP
fnp-8974	210	9	cns	cns	PROPN
fnp-8974	210	10	-	-	PUNCT
fnp-8974	210	11	gvhd	gvhd	NOUN
fnp-8974	210	12	,	,	PUNCT
fnp-8974	210	13	corresponding	correspond	VERB
fnp-8974	210	14	to	to	ADP
fnp-8974	210	15	a	a	DET
fnp-8974	210	16	prevalence	prevalence	NOUN
fnp-8974	210	17	of	of	ADP
fnp-8974	210	18	0.6	0.6	NUM
fnp-8974	210	19	 	 	SPACE
fnp-8974	210	20	%	%	NOUN
fnp-8974	210	21	.	.	PUNCT
fnp-8974	211	1	cns	cns	NOUN
fnp-8974	211	2	-	-	PUNCT
fnp-8974	211	3	gvhd	gvhd	NOUN
fnp-8974	211	4	manifested	manifest	VERB
fnp-8974	211	5	shortly	shortly	ADV
fnp-8974	211	6	after	after	ADP
fnp-8974	211	7	discontinuation	discontinuation	NOUN
fnp-8974	211	8	of	of	ADP
fnp-8974	211	9	immunosuppression	immunosuppression	NOUN
fnp-8974	211	10	in	in	ADP
fnp-8974	211	11	all	all	DET
fnp-8974	211	12	patients	patient	NOUN
fnp-8974	211	13	.	.	PUNCT
fnp-8974	212	1	under	under	ADP
fnp-8974	212	2	high	high	ADV
fnp-8974	212	3	-	-	PUNCT
fnp-8974	212	4	dose	dose	NOUN
fnp-8974	212	5	glucocorticoid	glucocorticoid	NOUN
fnp-8974	212	6	therapy	therapy	NOUN
fnp-8974	212	7	,	,	PUNCT
fnp-8974	212	8	clinical	clinical	ADJ
fnp-8974	212	9	response	response	NOUN
fnp-8974	212	10	was	be	AUX
fnp-8974	212	11	varying	vary	VERB
fnp-8974	212	12	.	.	PUNCT
fnp-8974	213	1	histologically	histologically	ADV
fnp-8974	213	2	,	,	PUNCT
fnp-8974	213	3	cns	cns	NOUN
fnp-8974	213	4	-	-	PUNCT
fnp-8974	213	5	gvhd	gvhd	NOUN
fnp-8974	213	6	displayed	display	VERB
fnp-8974	213	7	perivascular	perivascular	ADJ
fnp-8974	213	8	and	and	CCONJ
fnp-8974	213	9	parenchymal	parenchymal	ADJ
fnp-8974	213	10	infiltrates	infiltrate	NOUN
fnp-8974	213	11	,	,	PUNCT
fnp-8974	213	12	predominantly	predominantly	ADV
fnp-8974	213	13	consisting	consist	VERB
fnp-8974	213	14	of	of	ADP
fnp-8974	213	15	cd8	cd8	PROPN
fnp-8974	213	16	-	-	ADJ
fnp-8974	213	17	positive	positive	ADJ
fnp-8974	213	18	t	t	NOUN
fnp-8974	213	19	-	-	PUNCT
fnp-8974	213	20	lymphocytes	lymphocyte	NOUN
fnp-8974	213	21	.	.	PUNCT
fnp-8974	214	1	we	we	PRON
fnp-8974	214	2	identified	identify	VERB
fnp-8974	214	3	two	two	NUM
fnp-8974	214	4	inflammation	inflammation	NOUN
fnp-8974	214	5	patterns	pattern	NOUN
fnp-8974	214	6	:	:	PUNCT
fnp-8974	214	7	one	one	NUM
fnp-8974	214	8	adaptive	adaptive	ADJ
fnp-8974	214	9	-	-	PUNCT
fnp-8974	214	10	immune	immune	NOUN
fnp-8974	214	11	-	-	PUNCT
fnp-8974	214	12	response	response	NOUN
fnp-8974	214	13	pattern	pattern	NOUN
fnp-8974	214	14	dominated	dominate	VERB
fnp-8974	214	15	by	by	ADP
fnp-8974	214	16	lymphocytic	lymphocytic	ADJ
fnp-8974	214	17	infiltration	infiltration	NOUN
fnp-8974	214	18	(	(	PUNCT
fnp-8974	214	19	4	4	NUM
fnp-8974	214	20	patients	patient	NOUN
fnp-8974	214	21	)	)	PUNCT
fnp-8974	214	22	and	and	CCONJ
fnp-8974	214	23	one	one	NUM
fnp-8974	214	24	innate	innate	ADJ
fnp-8974	214	25	-	-	PUNCT
fnp-8974	214	26	immune	immune	NOUN
fnp-8974	214	27	-	-	PUNCT
fnp-8974	214	28	response	response	NOUN
fnp-8974	214	29	pattern	pattern	NOUN
fnp-8974	214	30	dominated	dominate	VERB
fnp-8974	214	31	by	by	ADP
fnp-8974	214	32	macrophage	macrophage	ADJ
fnp-8974	214	33	infiltration	infiltration	NOUN
fnp-8974	214	34	and	and	CCONJ
fnp-8974	214	35	phagocytosis	phagocytosis	NOUN
fnp-8974	214	36	(	(	PUNCT
fnp-8974	214	37	3	3	NUM
fnp-8974	214	38	patients	patient	NOUN
fnp-8974	214	39	)	)	PUNCT
fnp-8974	214	40	.	.	PUNCT
fnp-8974	215	1	conclusion(s	conclusion(s	NOUN
fnp-8974	215	2	):	):	PUNCT
fnp-8974	215	3	cns	cns	NOUN
fnp-8974	215	4	-	-	PUNCT
fnp-8974	215	5	gvhd	gvhd	NOUN
fnp-8974	215	6	is	be	AUX
fnp-8974	215	7	uncommon	uncommon	ADJ
fnp-8974	215	8	but	but	CCONJ
fnp-8974	215	9	clinically	clinically	ADV
fnp-8974	215	10	significant	significant	ADJ
fnp-8974	215	11	.	.	PUNCT
fnp-8974	216	1	its	its	PRON
fnp-8974	216	2	manifestation	manifestation	NOUN
fnp-8974	216	3	shortly	shortly	ADV
fnp-8974	216	4	after	after	ADP
fnp-8974	216	5	discontinuation	discontinuation	NOUN
fnp-8974	216	6	of	of	ADP
fnp-8974	216	7	immunosuppression	immunosuppression	NOUN
fnp-8974	216	8	supports	support	VERB
fnp-8974	216	9	a	a	DET
fnp-8974	216	10	gvhd	gvhd	NOUN
fnp-8974	216	11	-	-	PUNCT
fnp-8974	216	12	related	relate	VERB
fnp-8974	216	13	pathophysiology	pathophysiology	NOUN
fnp-8974	216	14	.	.	PUNCT
fnp-8974	217	1	histopathological	histopathological	ADJ
fnp-8974	217	2	findings	finding	NOUN
fnp-8974	217	3	suggest	suggest	VERB
fnp-8974	217	4	distinct	distinct	ADJ
fnp-8974	217	5	immune	immune	ADJ
fnp-8974	217	6	response	response	NOUN
fnp-8974	217	7	patterns	pattern	NOUN
fnp-8974	217	8	that	that	PRON
fnp-8974	217	9	may	may	AUX
fnp-8974	217	10	reflect	reflect	VERB
fnp-8974	217	11	different	different	ADJ
fnp-8974	217	12	stages	stage	NOUN
fnp-8974	217	13	of	of	ADP
fnp-8974	217	14	cns	cns	NOUN
fnp-8974	217	15	-	-	PUNCT
fnp-8974	217	16	gvhd	gvhd	NOUN
fnp-8974	217	17	.	.	PUNCT
fnp-8974	218	1	p16	p16	PROPN
fnp-8974	218	2	free	free	ADJ
fnp-8974	218	3	neuropathol	neuropathol	NOUN
fnp-8974	218	4	6:17:27	6:17:27	NUM
fnp-8974	218	5	hpgv-1	hpgv-1	PROPN
fnp-8974	218	6	is	be	AUX
fnp-8974	218	7	infecting	infect	VERB
fnp-8974	218	8	glial	glial	ADJ
fnp-8974	218	9	cells	cell	NOUN
fnp-8974	218	10	in	in	ADP
fnp-8974	218	11	immunosuppressed	immunosuppressed	ADJ
fnp-8974	218	12	patients	patient	NOUN
fnp-8974	218	13	helena	helena	PROPN
fnp-8974	218	14	radbruch1	radbruch1	PROPN
fnp-8974	218	15	,	,	PUNCT
fnp-8974	218	16	jenny	jenny	PROPN
fnp-8974	218	17	meinhardt1	meinhardt1	PROPN
fnp-8974	218	18	,	,	PUNCT
fnp-8974	218	19	raphael	raphael	PROPN
fnp-8974	218	20	raspe1	raspe1	PROPN
fnp-8974	218	21	,	,	PUNCT
fnp-8974	218	22	julia	julia	PROPN
fnp-8974	218	23	melchert1	melchert1	PROPN
fnp-8974	218	24	,	,	PUNCT
fnp-8974	218	25	victor	victor	PROPN
fnp-8974	218	26	corman1	corman1	PROPN
fnp-8974	218	27	,	,	PUNCT
fnp-8974	218	28	emanuel	emanuel	PROPN
fnp-8974	218	29	wyler2	wyler2	PROPN
fnp-8974	218	30	,	,	PUNCT
fnp-8974	218	31	klemens	klemen	NOUN
fnp-8974	218	32	ruprecht1	ruprecht1	NOUN
fnp-8974	218	33	,	,	PUNCT
fnp-8974	218	34	franziska	franziska	PROPN
fnp-8974	218	35	scheibe1	scheibe1	PROPN
fnp-8974	218	36	,	,	PUNCT
fnp-8974	218	37	eberhard	eberhard	ADJ
fnp-8974	218	38	siebert1	siebert1	NOUN
fnp-8974	218	39	1	1	NUM
fnp-8974	218	40	charité	charité	PROPN
fnp-8974	218	41	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	218	42	berlin	berlin	PROPN
fnp-8974	218	43	,	,	PUNCT
fnp-8974	218	44	institut	institut	PROPN
fnp-8974	218	45	für	für	PROPN
fnp-8974	218	46	neuropathologie	neuropathologie	PROPN
fnp-8974	218	47	,	,	PUNCT
fnp-8974	218	48	berlin	berlin	PROPN
fnp-8974	218	49	,	,	PUNCT
fnp-8974	218	50	germany	germany	PROPN
fnp-8974	218	51	2	2	NUM
fnp-8974	218	52	max	max	PROPN
fnp-8974	218	53	delbrück	delbrück	PROPN
fnp-8974	218	54	center	center	PROPN
fnp-8974	218	55	für	für	PROPN
fnp-8974	218	56	molekulare	molekulare	PROPN
fnp-8974	218	57	medizin	medizin	PROPN
fnp-8974	218	58	,	,	PUNCT
fnp-8974	218	59	berlin	berlin	PROPN
fnp-8974	218	60	,	,	PUNCT
fnp-8974	218	61	germany	germany	PROPN
fnp-8974	218	62	background	background	NOUN
fnp-8974	218	63	:	:	PUNCT
fnp-8974	218	64	pegivirus	pegivirus	NOUN
fnp-8974	218	65	hominis	hominis	X
fnp-8974	218	66	(	(	PUNCT
fnp-8974	218	67	hpgv-1	hpgv-1	X
fnp-8974	218	68	)	)	PUNCT
fnp-8974	218	69	is	be	AUX
fnp-8974	218	70	a	a	DET
fnp-8974	218	71	single	single	ADJ
fnp-8974	218	72	-	-	PUNCT
fnp-8974	218	73	stranded	strand	VERB
fnp-8974	218	74	rna	rna	NOUN
fnp-8974	218	75	flavivirus	flaviviru	NOUN
fnp-8974	218	76	previously	previously	ADV
fnp-8974	218	77	considered	consider	VERB
fnp-8974	218	78	non	non	ADJ
fnp-8974	218	79	-	-	ADJ
fnp-8974	218	80	pathogenic	pathogenic	ADJ
fnp-8974	218	81	in	in	ADP
fnp-8974	218	82	humans	human	NOUN
fnp-8974	218	83	,	,	PUNCT
fnp-8974	218	84	although	although	SCONJ
fnp-8974	218	85	it	it	PRON
fnp-8974	218	86	has	have	AUX
fnp-8974	218	87	been	be	AUX
fnp-8974	218	88	reported	report	VERB
fnp-8974	218	89	in	in	ADP
fnp-8974	218	90	association	association	NOUN
fnp-8974	218	91	with	with	ADP
fnp-8974	218	92	leukoencephalitis	leukoencephalitis	ADJ
fnp-8974	218	93	and	and	CCONJ
fnp-8974	218	94	myelitis	myelitis	NOUN
fnp-8974	218	95	in	in	ADP
fnp-8974	218	96	e.g.	e.g.	ADV
fnp-8974	218	97	the	the	DET
fnp-8974	218	98	context	context	NOUN
fnp-8974	218	99	of	of	ADP
fnp-8974	218	100	hiv	hiv	PROPN
fnp-8974	218	101	.	.	PUNCT
fnp-8974	219	1	objective(s	objective(s	NOUN
fnp-8974	219	2	):	):	PUNCT
fnp-8974	219	3	we	we	PRON
fnp-8974	219	4	want	want	VERB
fnp-8974	219	5	to	to	PART
fnp-8974	219	6	investigate	investigate	VERB
fnp-8974	219	7	the	the	DET
fnp-8974	219	8	neuropathological	neuropathological	ADJ
fnp-8974	219	9	manifestation	manifestation	NOUN
fnp-8974	219	10	of	of	ADP
fnp-8974	219	11	pegivirus	pegivirus	NOUN
fnp-8974	219	12	-	-	PUNCT
fnp-8974	219	13	associated	associate	VERB
fnp-8974	219	14	encephalomyelitis	encephalomyelitis	NOUN
fnp-8974	219	15	(	(	PUNCT
fnp-8974	219	16	paem	paem	NOUN
fnp-8974	219	17	)	)	PUNCT
fnp-8974	219	18	.	.	PUNCT
fnp-8974	220	1	question	question	NOUN
fnp-8974	220	2	:	:	PUNCT
fnp-8974	220	3	is	be	AUX
fnp-8974	220	4	paem	paem	VERB
fnp-8974	220	5	a	a	DET
fnp-8974	220	6	distinct	distinct	ADJ
fnp-8974	220	7	encephalomyelitis	encephalomyelitis	NOUN
fnp-8974	220	8	in	in	ADP
fnp-8974	220	9	immunocompromised	immunocompromise	VERB
fnp-8974	220	10	patients	patient	NOUN
fnp-8974	220	11	?	?	PUNCT
fnp-8974	221	1	method(s	method(	VERB
fnp-8974	221	2	):	):	PUNCT
fnp-8974	221	3	here	here	ADV
fnp-8974	221	4	,	,	PUNCT
fnp-8974	221	5	we	we	PRON
fnp-8974	221	6	report	report	VERB
fnp-8974	221	7	a	a	DET
fnp-8974	221	8	neuropathological	neuropathological	ADJ
fnp-8974	221	9	work	work	NOUN
fnp-8974	221	10	up	up	ADP
fnp-8974	221	11	of	of	ADP
fnp-8974	221	12	two	two	NUM
fnp-8974	221	13	chronically	chronically	ADV
fnp-8974	221	14	immunosuppressed	immunosuppressed	ADJ
fnp-8974	221	15	patients	patient	NOUN
fnp-8974	221	16	presenting	present	VERB
fnp-8974	221	17	with	with	ADP
fnp-8974	221	18	an	an	DET
fnp-8974	221	19	encephalomyelitis	encephalomyelitis	NOUN
fnp-8974	221	20	associated	associate	VERB
fnp-8974	221	21	with	with	ADP
fnp-8974	221	22	hpgv-1	hpgv-1	NUM
fnp-8974	221	23	detection	detection	NOUN
fnp-8974	221	24	in	in	ADP
fnp-8974	221	25	the	the	DET
fnp-8974	221	26	central	central	ADJ
fnp-8974	221	27	nervous	nervous	ADJ
fnp-8974	221	28	system	system	NOUN
fnp-8974	221	29	(	(	PUNCT
fnp-8974	221	30	cns	cns	NOUN
fnp-8974	221	31	)	)	PUNCT
fnp-8974	221	32	.	.	PUNCT
fnp-8974	222	1	result(s	result(s	PROPN
fnp-8974	222	2	):	):	PUNCT
fnp-8974	222	3	autopsies	autopsy	NOUN
fnp-8974	222	4	revealed	reveal	VERB
fnp-8974	222	5	infiltration	infiltration	NOUN
fnp-8974	222	6	by	by	ADP
fnp-8974	222	7	macrophages	macrophage	NOUN
fnp-8974	222	8	and	and	CCONJ
fnp-8974	222	9	t	t	NOUN
fnp-8974	222	10	cells	cell	NOUN
fnp-8974	222	11	,	,	PUNCT
fnp-8974	222	12	upregulation	upregulation	NOUN
fnp-8974	222	13	of	of	ADP
fnp-8974	222	14	hla	hla	PROPN
fnp-8974	222	15	-	-	PUNCT
fnp-8974	222	16	dr	dr	PROPN
fnp-8974	222	17	,	,	PUNCT
fnp-8974	222	18	tissue	tissue	NOUN
fnp-8974	222	19	destruction	destruction	NOUN
fnp-8974	222	20	—	—	PUNCT
fnp-8974	222	21	findings	finding	NOUN
fnp-8974	222	22	compatible	compatible	ADJ
fnp-8974	222	23	with	with	ADP
fnp-8974	222	24	viral	viral	ADJ
fnp-8974	222	25	encephalomyelitis	encephalomyelitis	NOUN
fnp-8974	222	26	in	in	ADP
fnp-8974	222	27	areas	area	NOUN
fnp-8974	222	28	where	where	SCONJ
fnp-8974	222	29	we	we	PRON
fnp-8974	222	30	could	could	AUX
fnp-8974	222	31	detect	detect	VERB
fnp-8974	222	32	hpgv-1	hpgv-1	PRON
fnp-8974	222	33	rna	rna	NOUN
fnp-8974	222	34	by	by	ADP
fnp-8974	222	35	pcr	pcr	PROPN
fnp-8974	222	36	and	and	CCONJ
fnp-8974	222	37	in	in	ADP
fnp-8974	222	38	-	-	PUNCT
fnp-8974	222	39	situ	situ	NOUN
fnp-8974	222	40	hybridization	hybridization	NOUN
fnp-8974	222	41	(	(	PUNCT
fnp-8974	222	42	ish	ish	PROPN
fnp-8974	222	43	)	)	PUNCT
fnp-8974	222	44	.	.	PUNCT
fnp-8974	223	1	pgv-1	pgv-1	PUNCT
fnp-8974	223	2	rna	rna	VERB
fnp-8974	223	3	viral	viral	ADJ
fnp-8974	223	4	loads	load	NOUN
fnp-8974	223	5	were	be	AUX
fnp-8974	223	6	significantly	significantly	ADV
fnp-8974	223	7	higher	high	ADJ
fnp-8974	223	8	in	in	ADP
fnp-8974	223	9	central	central	ADJ
fnp-8974	223	10	and	and	CCONJ
fnp-8974	223	11	peripheral	peripheral	ADJ
fnp-8974	223	12	nervous	nervous	ADJ
fnp-8974	223	13	system	system	NOUN
fnp-8974	223	14	compared	compare	VERB
fnp-8974	223	15	to	to	ADP
fnp-8974	223	16	peripheral	peripheral	ADJ
fnp-8974	223	17	organs	organ	NOUN
fnp-8974	223	18	,	,	PUNCT
fnp-8974	223	19	with	with	ADP
fnp-8974	223	20	the	the	DET
fnp-8974	223	21	highest	high	ADJ
fnp-8974	223	22	viral	viral	ADJ
fnp-8974	223	23	loads	load	NOUN
fnp-8974	223	24	in	in	ADP
fnp-8974	223	25	the	the	DET
fnp-8974	223	26	optic	optic	ADJ
fnp-8974	223	27	nerves	nerve	NOUN
fnp-8974	223	28	and	and	CCONJ
fnp-8974	223	29	cervical	cervical	ADJ
fnp-8974	223	30	spinal	spinal	NOUN
fnp-8974	223	31	cord	cord	NOUN
fnp-8974	223	32	,	,	PUNCT
fnp-8974	223	33	corresponding	correspond	VERB
fnp-8974	223	34	to	to	ADP
fnp-8974	223	35	the	the	DET
fnp-8974	223	36	affected	affected	ADJ
fnp-8974	223	37	clinical	clinical	ADJ
fnp-8974	223	38	and	and	CCONJ
fnp-8974	223	39	radiologic	radiologic	ADJ
fnp-8974	223	40	regions	region	NOUN
fnp-8974	223	41	.	.	PUNCT
fnp-8974	224	1	ish	ish	PROPN
fnp-8974	224	2	showed	show	VERB
fnp-8974	224	3	viral	viral	ADJ
fnp-8974	224	4	rna	rna	NOUN
fnp-8974	224	5	mainly	mainly	ADV
fnp-8974	224	6	in	in	ADP
fnp-8974	224	7	glial	glial	ADJ
fnp-8974	224	8	cells	cell	NOUN
fnp-8974	224	9	of	of	ADP
fnp-8974	224	10	the	the	DET
fnp-8974	224	11	white	white	ADJ
fnp-8974	224	12	matter	matter	NOUN
fnp-8974	224	13	.	.	PUNCT
fnp-8974	225	1	analysis	analysis	NOUN
fnp-8974	225	2	of	of	ADP
fnp-8974	225	3	complete	complete	ADJ
fnp-8974	225	4	hpgv-1	hpgv-1	NUM
fnp-8974	225	5	genome	genome	NOUN
fnp-8974	225	6	sequences	sequence	NOUN
fnp-8974	225	7	obtained	obtain	VERB
fnp-8974	225	8	from	from	ADP
fnp-8974	225	9	tissue	tissue	NOUN
fnp-8974	225	10	samples	sample	NOUN
fnp-8974	225	11	revealed	reveal	VERB
fnp-8974	225	12	single	single	ADJ
fnp-8974	225	13	nucleotide	nucleotide	NOUN
fnp-8974	225	14	polymorphisms	polymorphism	NOUN
fnp-8974	225	15	,	,	PUNCT
fnp-8974	225	16	amino	amino	NOUN
fnp-8974	225	17	acid	acid	NOUN
fnp-8974	225	18	substitutions	substitution	NOUN
fnp-8974	225	19	,	,	PUNCT
fnp-8974	225	20	and	and	CCONJ
fnp-8974	225	21	deletions	deletion	NOUN
fnp-8974	225	22	within	within	ADP
fnp-8974	225	23	the	the	DET
fnp-8974	225	24	cns	cns	NOUN
fnp-8974	225	25	.	.	PUNCT
fnp-8974	226	1	conclusion(s	conclusion(s	NOUN
fnp-8974	226	2	):	):	PUNCT
fnp-8974	226	3	paem	paem	NOUN
fnp-8974	226	4	is	be	AUX
fnp-8974	226	5	a	a	DET
fnp-8974	226	6	distinct	distinct	ADJ
fnp-8974	226	7	and	and	CCONJ
fnp-8974	226	8	severe	severe	ADJ
fnp-8974	226	9	form	form	NOUN
fnp-8974	226	10	of	of	ADP
fnp-8974	226	11	encephalomyelitis	encephalomyelitis	NOUN
fnp-8974	226	12	in	in	ADP
fnp-8974	226	13	chronically	chronically	ADV
fnp-8974	226	14	immunosuppressed	immunosuppressed	ADJ
fnp-8974	226	15	patients	patient	NOUN
fnp-8974	226	16	,	,	PUNCT
fnp-8974	226	17	predominantly	predominantly	ADV
fnp-8974	226	18	affecting	affect	VERB
fnp-8974	226	19	the	the	DET
fnp-8974	226	20	optic	optic	ADJ
fnp-8974	226	21	tracts	tract	NOUN
fnp-8974	226	22	as	as	ADV
fnp-8974	226	23	well	well	ADV
fnp-8974	226	24	as	as	ADP
fnp-8974	226	25	the	the	DET
fnp-8974	226	26	motor	motor	NOUN
fnp-8974	226	27	and	and	CCONJ
fnp-8974	226	28	sensory	sensory	ADJ
fnp-8974	226	29	pathways	pathway	NOUN
fnp-8974	226	30	of	of	ADP
fnp-8974	226	31	the	the	DET
fnp-8974	226	32	brain	brain	NOUN
fnp-8974	226	33	and	and	CCONJ
fnp-8974	226	34	spinal	spinal	ADJ
fnp-8974	226	35	cord	cord	NOUN
fnp-8974	226	36	.	.	PUNCT
fnp-8974	227	1	the	the	DET
fnp-8974	227	2	detection	detection	NOUN
fnp-8974	227	3	of	of	ADP
fnp-8974	227	4	viral	viral	ADJ
fnp-8974	227	5	rna	rna	NOUN
fnp-8974	227	6	in	in	ADP
fnp-8974	227	7	glial	glial	ADJ
fnp-8974	227	8	cells	cell	NOUN
fnp-8974	227	9	,	,	PUNCT
fnp-8974	227	10	genetically	genetically	ADV
fnp-8974	227	11	distinct	distinct	ADJ
fnp-8974	227	12	viral	viral	ADJ
fnp-8974	227	13	populations	population	NOUN
fnp-8974	227	14	and	and	CCONJ
fnp-8974	227	15	evidence	evidence	NOUN
fnp-8974	227	16	of	of	ADP
fnp-8974	227	17	independent	independent	ADJ
fnp-8974	227	18	viral	viral	ADJ
fnp-8974	227	19	replication	replication	NOUN
fnp-8974	227	20	in	in	ADP
fnp-8974	227	21	the	the	DET
fnp-8974	227	22	cns	cns	NOUN
fnp-8974	227	23	supports	support	VERB
fnp-8974	227	24	a	a	DET
fnp-8974	227	25	causative	causative	ADJ
fnp-8974	227	26	role	role	NOUN
fnp-8974	227	27	of	of	ADP
fnp-8974	227	28	hpgv-1	hpgv-1	NUM
fnp-8974	227	29	in	in	ADP
fnp-8974	227	30	paem	paem	NOUN
fnp-8974	227	31	.	.	PUNCT
fnp-8974	228	1	p17	p17	ADJ
fnp-8974	228	2	free	free	ADJ
fnp-8974	228	3	neuropathol	neuropathol	NOUN
fnp-8974	228	4	6:17:28	6:17:28	PROPN
fnp-8974	228	5	t	t	PROPN
fnp-8974	228	6	cell	cell	NOUN
fnp-8974	228	7	infiltration	infiltration	NOUN
fnp-8974	228	8	patterns	pattern	NOUN
fnp-8974	228	9	and	and	CCONJ
fnp-8974	228	10	clinical	clinical	ADJ
fnp-8974	228	11	correlates	correlate	NOUN
fnp-8974	228	12	in	in	ADP
fnp-8974	228	13	natalizumab	natalizumab	NOUN
fnp-8974	228	14	-	-	PUNCT
fnp-8974	228	15	related	relate	VERB
fnp-8974	228	16	pml	pml	NOUN
fnp-8974	228	17	lesions	lesion	NOUN
fnp-8974	228	18	benita	benita	PROPN
fnp-8974	228	19	raabe1	raabe1	PROPN
fnp-8974	228	20	,	,	PUNCT
fnp-8974	228	21	adriane	adriane	PROPN
fnp-8974	228	22	kutllovci1	kutllovci1	PROPN
fnp-8974	228	23	,	,	PUNCT
fnp-8974	228	24	lidia	lidia	PROPN
fnp-8974	228	25	stork1	stork1	PROPN
fnp-8974	228	26	,	,	PUNCT
fnp-8974	228	27	imke	imke	PROPN
fnp-8974	228	28	metz1	metz1	NOUN
fnp-8974	228	29	1	1	NUM
fnp-8974	228	30	institut	institut	PROPN
fnp-8974	228	31	für	für	PROPN
fnp-8974	228	32	neuropathologie	neuropathologie	PROPN
fnp-8974	228	33	,	,	PUNCT
fnp-8974	228	34	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	228	35	göttingen	göttingen	PROPN
fnp-8974	228	36	,	,	PUNCT
fnp-8974	228	37	göttingen	göttingen	NOUN
fnp-8974	228	38	,	,	PUNCT
fnp-8974	228	39	germany	germany	PROPN
fnp-8974	228	40	background	background	NOUN
fnp-8974	228	41	:	:	PUNCT
fnp-8974	228	42	progressive	progressive	ADJ
fnp-8974	228	43	multifocal	multifocal	ADJ
fnp-8974	228	44	leukoencephalopathy	leukoencephalopathy	NOUN
fnp-8974	228	45	(	(	PUNCT
fnp-8974	228	46	pml	pml	NOUN
fnp-8974	228	47	)	)	PUNCT
fnp-8974	228	48	is	be	AUX
fnp-8974	228	49	an	an	DET
fnp-8974	228	50	opportunistic	opportunistic	ADJ
fnp-8974	228	51	viral	viral	ADJ
fnp-8974	228	52	demyelinating	demyelinate	VERB
fnp-8974	228	53	brain	brain	NOUN
fnp-8974	228	54	disease	disease	NOUN
fnp-8974	228	55	caused	cause	VERB
fnp-8974	228	56	by	by	ADP
fnp-8974	228	57	the	the	DET
fnp-8974	228	58	jc	jc	PROPN
fnp-8974	228	59	virus	virus	NOUN
fnp-8974	228	60	that	that	PRON
fnp-8974	228	61	may	may	AUX
fnp-8974	228	62	occur	occur	VERB
fnp-8974	228	63	during	during	ADP
fnp-8974	228	64	natalizumab	natalizumab	NOUN
fnp-8974	228	65	treatment	treatment	NOUN
fnp-8974	228	66	for	for	ADP
fnp-8974	228	67	multiple	multiple	ADJ
fnp-8974	228	68	sclerosis	sclerosis	NOUN
fnp-8974	228	69	.	.	PUNCT
fnp-8974	229	1	tissue	tissue	NOUN
fnp-8974	229	2	resident	resident	NOUN
fnp-8974	229	3	memory	memory	NOUN
fnp-8974	229	4	(	(	PUNCT
fnp-8974	229	5	trm	trm	PROPN
fnp-8974	229	6	)	)	PUNCT
fnp-8974	230	1	cd8	cd8	PROPN
fnp-8974	230	2	+	+	PROPN
fnp-8974	230	3	t	t	NOUN
fnp-8974	230	4	cells	cell	NOUN
fnp-8974	230	5	are	be	AUX
fnp-8974	230	6	long	long	ADV
fnp-8974	230	7	-	-	PUNCT
fnp-8974	230	8	lived	live	VERB
fnp-8974	230	9	stationary	stationary	ADJ
fnp-8974	230	10	immune	immune	ADJ
fnp-8974	230	11	cells	cell	NOUN
fnp-8974	230	12	that	that	PRON
fnp-8974	230	13	provide	provide	VERB
fnp-8974	230	14	key	key	ADJ
fnp-8974	230	15	frontline	frontline	NOUN
fnp-8974	230	16	defense	defense	NOUN
fnp-8974	230	17	against	against	ADP
fnp-8974	230	18	viral	viral	ADJ
fnp-8974	230	19	reactivation	reactivation	NOUN
fnp-8974	230	20	.	.	PUNCT
fnp-8974	231	1	cd4	cd4	PROPN
fnp-8974	231	2	+	+	PROPN
fnp-8974	231	3	and	and	CCONJ
fnp-8974	231	4	cd8	cd8	PROPN
fnp-8974	231	5	+	+	PROPN
fnp-8974	231	6	t	t	NOUN
fnp-8974	231	7	cell	cell	NOUN
fnp-8974	231	8	populations	population	NOUN
fnp-8974	231	9	are	be	AUX
fnp-8974	231	10	reported	report	VERB
fnp-8974	231	11	to	to	PART
fnp-8974	231	12	be	be	AUX
fnp-8974	231	13	essential	essential	ADJ
fnp-8974	231	14	for	for	ADP
fnp-8974	231	15	antiviral	antiviral	ADJ
fnp-8974	231	16	immunity	immunity	NOUN
fnp-8974	231	17	in	in	ADP
fnp-8974	231	18	pml	pml	PROPN
fnp-8974	231	19	.	.	PUNCT
fnp-8974	232	1	method(s	method(	VERB
fnp-8974	232	2	):	):	PUNCT
fnp-8974	232	3	we	we	PRON
fnp-8974	232	4	investigated	investigate	VERB
fnp-8974	232	5	t	t	NOUN
fnp-8974	232	6	cell	cell	NOUN
fnp-8974	232	7	infiltration	infiltration	NOUN
fnp-8974	232	8	patterns	pattern	NOUN
fnp-8974	232	9	(	(	PUNCT
fnp-8974	232	10	trm	trm	PROPN
fnp-8974	232	11	cd8	cd8	PROPN
fnp-8974	232	12	+	+	PROPN
fnp-8974	232	13	t	t	NOUN
fnp-8974	232	14	cells	cell	NOUN
fnp-8974	232	15	,	,	PUNCT
fnp-8974	232	16	cd4	cd4	PROPN
fnp-8974	232	17	+	+	PROPN
fnp-8974	232	18	t	t	NOUN
fnp-8974	232	19	cells	cell	NOUN
fnp-8974	232	20	,	,	PUNCT
fnp-8974	232	21	cd8	cd8	PROPN
fnp-8974	232	22	+	+	PROPN
fnp-8974	232	23	t	t	NOUN
fnp-8974	232	24	cells	cell	NOUN
fnp-8974	232	25	)	)	PUNCT
fnp-8974	232	26	,	,	PUNCT
fnp-8974	232	27	viral	viral	ADJ
fnp-8974	232	28	clearance	clearance	NOUN
fnp-8974	232	29	,	,	PUNCT
fnp-8974	232	30	and	and	CCONJ
fnp-8974	232	31	clinical	clinical	ADJ
fnp-8974	232	32	outcomes	outcome	NOUN
fnp-8974	232	33	in	in	ADP
fnp-8974	232	34	natalizumab	natalizumab	NOUN
fnp-8974	232	35	-	-	PUNCT
fnp-8974	232	36	associated	associate	VERB
fnp-8974	232	37	pml	pml	NOUN
fnp-8974	232	38	,	,	PUNCT
fnp-8974	232	39	and	and	CCONJ
fnp-8974	232	40	compared	compare	VERB
fnp-8974	232	41	them	they	PRON
fnp-8974	232	42	with	with	ADP
fnp-8974	232	43	classic	classic	ADJ
fnp-8974	232	44	pml	pml	NOUN
fnp-8974	232	45	lesions	lesion	NOUN
fnp-8974	232	46	(	(	PUNCT
fnp-8974	232	47	<	<	X
fnp-8974	232	48	 	 	SPACE
fnp-8974	232	49	500	500	NUM
fnp-8974	232	50	t	t	NOUN
fnp-8974	232	51	cells	cell	NOUN
fnp-8974	232	52	/	/	SYM
fnp-8974	232	53	mm²	mm²	PROPN
fnp-8974	232	54	)	)	PUNCT
fnp-8974	232	55	and	and	CCONJ
fnp-8974	232	56	inflammatory	inflammatory	ADJ
fnp-8974	232	57	pml	pml	NOUN
fnp-8974	232	58	lesions	lesion	NOUN
fnp-8974	232	59	(	(	PUNCT
fnp-8974	232	60	>	>	SYM
fnp-8974	232	61	 	 	SPACE
fnp-8974	232	62	500	500	NUM
fnp-8974	232	63	t	t	NOUN
fnp-8974	232	64	cells	cell	NOUN
fnp-8974	232	65	/	/	SYM
fnp-8974	232	66	mm²	mm²	PROPN
fnp-8974	232	67	)	)	PUNCT
fnp-8974	232	68	from	from	ADP
fnp-8974	232	69	patients	patient	NOUN
fnp-8974	232	70	without	without	ADP
fnp-8974	232	71	prior	prior	ADJ
fnp-8974	232	72	natalizumab	natalizumab	NOUN
fnp-8974	232	73	exposure	exposure	NOUN
fnp-8974	232	74	.	.	PUNCT
fnp-8974	233	1	clinical	clinical	ADJ
fnp-8974	233	2	outcomes	outcome	NOUN
fnp-8974	233	3	were	be	AUX
fnp-8974	233	4	assessed	assess	VERB
fnp-8974	233	5	using	use	VERB
fnp-8974	233	6	the	the	DET
fnp-8974	233	7	expanded	expand	VERB
fnp-8974	233	8	disability	disability	NOUN
fnp-8974	233	9	status	status	NOUN
fnp-8974	233	10	scale	scale	NOUN
fnp-8974	233	11	(	(	PUNCT
fnp-8974	233	12	edss	edss	ADV
fnp-8974	233	13	)	)	PUNCT
fnp-8974	233	14	and	and	CCONJ
fnp-8974	233	15	modified	modify	VERB
fnp-8974	233	16	rankin	rankin	NOUN
fnp-8974	233	17	scale	scale	NOUN
fnp-8974	233	18	(	(	PUNCT
fnp-8974	233	19	mrs	mrs	PROPN
fnp-8974	233	20	)	)	PUNCT
fnp-8974	233	21	.	.	PUNCT
fnp-8974	234	1	result(s	result(s	PROPN
fnp-8974	234	2	):	):	PUNCT
fnp-8974	234	3	pml	pml	PROPN
fnp-8974	234	4	lesions	lesion	NOUN
fnp-8974	234	5	following	follow	VERB
fnp-8974	234	6	natalizumab	natalizumab	NOUN
fnp-8974	234	7	treatment	treatment	NOUN
fnp-8974	234	8	showed	show	VERB
fnp-8974	234	9	high	high	ADJ
fnp-8974	234	10	t	t	NOUN
fnp-8974	234	11	cell	cell	NOUN
fnp-8974	234	12	infiltration	infiltration	NOUN
fnp-8974	234	13	including	include	VERB
fnp-8974	234	14	trm	trm	PROPN
fnp-8974	234	15	cd8	cd8	PROPN
fnp-8974	234	16	+	+	PROPN
fnp-8974	234	17	t	t	PROPN
fnp-8974	234	18	cells	cell	NOUN
fnp-8974	234	19	(	(	PUNCT
fnp-8974	234	20	164.2	164.2	NUM
fnp-8974	234	21	 	 	SPACE
fnp-8974	234	22	cells	cell	NOUN
fnp-8974	234	23	/	/	SYM
fnp-8974	234	24	mm²	mm²	PROPN
fnp-8974	234	25	)	)	PUNCT
fnp-8974	234	26	,	,	PUNCT
fnp-8974	234	27	comparable	comparable	ADJ
fnp-8974	234	28	to	to	ADP
fnp-8974	234	29	inflammatory	inflammatory	ADJ
fnp-8974	234	30	pml	pml	NOUN
fnp-8974	234	31	lesions	lesion	NOUN
fnp-8974	234	32	without	without	ADP
fnp-8974	234	33	natalizumab	natalizumab	NOUN
fnp-8974	234	34	pretreatment	pretreatment	NOUN
fnp-8974	234	35	.	.	PUNCT
fnp-8974	235	1	elevated	elevate	VERB
fnp-8974	235	2	t	t	PROPN
fnp-8974	235	3	cell	cell	NOUN
fnp-8974	235	4	numbers	number	NOUN
fnp-8974	235	5	persisted	persist	VERB
fnp-8974	235	6	until	until	ADP
fnp-8974	235	7	234	234	NUM
fnp-8974	235	8	days	day	NOUN
fnp-8974	235	9	after	after	ADP
fnp-8974	235	10	the	the	DET
fnp-8974	235	11	last	last	ADJ
fnp-8974	235	12	natalizumab	natalizumab	NOUN
fnp-8974	235	13	infusion	infusion	NOUN
fnp-8974	235	14	.	.	PUNCT
fnp-8974	236	1	approximately	approximately	ADV
fnp-8974	236	2	four	four	NUM
fnp-8974	236	3	months	month	NOUN
fnp-8974	236	4	after	after	ADP
fnp-8974	236	5	natalizumab	natalizumab	NOUN
fnp-8974	236	6	withdrawal	withdrawal	PROPN
fnp-8974	236	7	,	,	PUNCT
fnp-8974	236	8	profound	profound	ADJ
fnp-8974	236	9	reduction	reduction	NOUN
fnp-8974	236	10	of	of	ADP
fnp-8974	236	11	virally	virally	ADV
fnp-8974	236	12	infected	infect	VERB
fnp-8974	236	13	cells	cell	NOUN
fnp-8974	236	14	was	be	AUX
fnp-8974	236	15	evident	evident	ADJ
fnp-8974	236	16	(	(	PUNCT
fnp-8974	236	17	>	>	SYM
fnp-8974	236	18	 	 	SPACE
fnp-8974	236	19	120	120	NUM
fnp-8974	236	20	days	day	NOUN
fnp-8974	236	21	:	:	PUNCT
fnp-8974	236	22	1.8	1.8	NUM
fnp-8974	236	23	 	 	SPACE
fnp-8974	236	24	cells	cell	NOUN
fnp-8974	236	25	/	/	SYM
fnp-8974	236	26	mm²	mm²	PROPN
fnp-8974	236	27	)	)	PUNCT
fnp-8974	236	28	.	.	PUNCT
fnp-8974	237	1	negative	negative	ADJ
fnp-8974	237	2	correlation	correlation	NOUN
fnp-8974	237	3	between	between	ADP
fnp-8974	237	4	cd8	cd8	PROPN
fnp-8974	237	5	+	+	PROPN
fnp-8974	237	6	cytotoxic	cytotoxic	ADJ
fnp-8974	237	7	t	t	NOUN
fnp-8974	237	8	cells	cell	NOUN
fnp-8974	237	9	and	and	CCONJ
fnp-8974	237	10	trm	trm	PROPN
fnp-8974	237	11	cd8	cd8	PROPN
fnp-8974	237	12	+	+	PROPN
fnp-8974	237	13	t	t	PROPN
fnp-8974	237	14	cells	cell	NOUN
fnp-8974	237	15	with	with	ADP
fnp-8974	237	16	clinical	clinical	ADJ
fnp-8974	237	17	disability	disability	NOUN
fnp-8974	237	18	scores	score	NOUN
fnp-8974	237	19	was	be	AUX
fnp-8974	237	20	observed	observe	VERB
fnp-8974	237	21	(	(	PUNCT
fnp-8974	237	22	edss	edss	ADV
fnp-8974	237	23	:	:	PUNCT
fnp-8974	238	1	p	p	X
fnp-8974	238	2	 	 	SPACE
fnp-8974	238	3	=	=	PRON
fnp-8974	238	4	 	 	SPACE
fnp-8974	238	5	0.05	0.05	NUM
fnp-8974	238	6	,	,	PUNCT
fnp-8974	238	7	p	p	X
fnp-8974	238	8	 	 	SPACE
fnp-8974	238	9	=	=	NOUN
fnp-8974	238	10	 	 	SPACE
fnp-8974	238	11	0.03	0.03	NUM
fnp-8974	238	12	;	;	PUNCT
fnp-8974	238	13	mrs	mrs	PROPN
fnp-8974	238	14	:	:	PUNCT
fnp-8974	238	15	p	p	X
fnp-8974	238	16	 	 	SPACE
fnp-8974	238	17	=	=	NOUN
fnp-8974	238	18	 	 	SPACE
fnp-8974	238	19	0.004	0.004	NUM
fnp-8974	238	20	,	,	PUNCT
fnp-8974	238	21	p	p	X
fnp-8974	238	22	 	 	SPACE
fnp-8974	238	23	=	=	NOUN
fnp-8974	238	24	 	 	SPACE
fnp-8974	238	25	0.03	0.03	NUM
fnp-8974	238	26	)	)	PUNCT
fnp-8974	238	27	.	.	PUNCT
fnp-8974	239	1	conclusion(s	conclusion(s	NOUN
fnp-8974	239	2	):	):	PUNCT
fnp-8974	239	3	after	after	ADP
fnp-8974	239	4	natalizumab	natalizumab	NOUN
fnp-8974	239	5	withdrawal	withdrawal	PROPN
fnp-8974	239	6	in	in	ADP
fnp-8974	239	7	pml	pml	PROPN
fnp-8974	239	8	,	,	PUNCT
fnp-8974	239	9	immune	immune	ADJ
fnp-8974	239	10	system	system	NOUN
fnp-8974	239	11	reconstitution	reconstitution	NOUN
fnp-8974	239	12	occurs	occur	VERB
fnp-8974	239	13	with	with	ADP
fnp-8974	239	14	profound	profound	ADJ
fnp-8974	239	15	viral	viral	ADJ
fnp-8974	239	16	clearance	clearance	NOUN
fnp-8974	239	17	at	at	ADP
fnp-8974	239	18	approximately	approximately	ADV
fnp-8974	239	19	four	four	NUM
fnp-8974	239	20	months	month	NOUN
fnp-8974	239	21	.	.	PUNCT
fnp-8974	240	1	cd8	cd8	PROPN
fnp-8974	240	2	+	+	PROPN
fnp-8974	240	3	cytotoxic	cytotoxic	ADJ
fnp-8974	240	4	t	t	NOUN
fnp-8974	240	5	cells	cell	NOUN
fnp-8974	240	6	,	,	PUNCT
fnp-8974	240	7	including	include	VERB
fnp-8974	240	8	trm	trm	PROPN
fnp-8974	240	9	cd8	cd8	PROPN
fnp-8974	240	10	+	+	PROPN
fnp-8974	240	11	t	t	NOUN
fnp-8974	240	12	cells	cell	NOUN
fnp-8974	240	13	,	,	PUNCT
fnp-8974	240	14	seem	seem	VERB
fnp-8974	240	15	to	to	PART
fnp-8974	240	16	play	play	VERB
fnp-8974	240	17	crucial	crucial	ADJ
fnp-8974	240	18	roles	role	NOUN
fnp-8974	240	19	in	in	ADP
fnp-8974	240	20	viral	viral	ADJ
fnp-8974	240	21	control	control	NOUN
fnp-8974	240	22	and	and	CCONJ
fnp-8974	240	23	are	be	AUX
fnp-8974	240	24	associated	associate	VERB
fnp-8974	240	25	with	with	ADP
fnp-8974	240	26	improved	improve	VERB
fnp-8974	240	27	clinical	clinical	ADJ
fnp-8974	240	28	outcomes	outcome	NOUN
fnp-8974	240	29	.	.	PUNCT
fnp-8974	241	1	p18	p18	ADJ
fnp-8974	241	2	free	free	ADJ
fnp-8974	241	3	neuropathol	neuropathol	NOUN
fnp-8974	241	4	6:17:29	6:17:29	NUM
fnp-8974	241	5	multiplexed	multiplexed	ADJ
fnp-8974	241	6	viral	viral	ADJ
fnp-8974	241	7	detection	detection	NOUN
fnp-8974	241	8	in	in	ADP
fnp-8974	241	9	brain	brain	NOUN
fnp-8974	241	10	tissue	tissue	NOUN
fnp-8974	241	11	–	–	PUNCT
fnp-8974	241	12	methodological	methodological	ADJ
fnp-8974	241	13	challenges	challenge	NOUN
fnp-8974	241	14	and	and	CCONJ
fnp-8974	241	15	opportunities	opportunity	NOUN
fnp-8974	241	16	raphael	raphael	PROPN
fnp-8974	241	17	raspe1	raspe1	PROPN
fnp-8974	241	18	,	,	PUNCT
fnp-8974	241	19	emanuel	emanuel	PROPN
fnp-8974	241	20	wyler2	wyler2	PROPN
fnp-8974	241	21	,	,	PUNCT
fnp-8974	241	22	viktor	viktor	NOUN
fnp-8974	241	23	horst1	horst1	PROPN
fnp-8974	241	24	,	,	PUNCT
fnp-8974	241	25	kristin	kristin	PROPN
fnp-8974	241	26	hartmann3	hartmann3	PROPN
fnp-8974	241	27	,	,	PUNCT
fnp-8974	241	28	osama	osama	PROPN
fnp-8974	241	29	mohamed3	mohamed3	PROPN
fnp-8974	241	30	,	,	PUNCT
fnp-8974	241	31	julia	julia	PROPN
fnp-8974	241	32	melchert4	melchert4	PROPN
fnp-8974	241	33	,	,	PUNCT
fnp-8974	241	34	jenny	jenny	PROPN
fnp-8974	241	35	meinhardt1	meinhardt1	PROPN
fnp-8974	241	36	,	,	PUNCT
fnp-8974	241	37	fabian	fabian	PROPN
fnp-8974	241	38	heinrich5	heinrich5	PROPN
fnp-8974	241	39	,	,	PUNCT
fnp-8974	241	40	julia	julia	PROPN
fnp-8974	241	41	berger6	berger6	PROPN
fnp-8974	241	42	,	,	PUNCT
fnp-8974	241	43	susanne	susanne	PROPN
fnp-8974	241	44	pfefferle6	pfefferle6	PROPN
fnp-8974	241	45	,	,	PUNCT
fnp-8974	241	46	shui	shui	PROPN
fnp-8974	241	47	-	-	PUNCT
fnp-8974	241	48	fen	fen	PROPN
fnp-8974	241	49	cheng3	cheng3	PROPN
fnp-8974	241	50	,	,	PUNCT
fnp-8974	241	51	leona	leona	PROPN
fnp-8974	241	52	kawelke1	kawelke1	PROPN
fnp-8974	241	53	,	,	PUNCT
fnp-8974	241	54	nikolaus	nikolaus	PROPN
fnp-8974	241	55	deigendesch7	deigendesch7	PROPN
fnp-8974	241	56	,	,	PUNCT
fnp-8974	241	57	stephan	stephan	PROPN
fnp-8974	241	58	frank7	frank7	PROPN
fnp-8974	241	59	,	,	PUNCT
fnp-8974	241	60	christel	christel	PROPN
fnp-8974	241	61	bonnas8	bonnas8	PROPN
fnp-8974	241	62	,	,	PUNCT
fnp-8974	241	63	jakob	jakob	PROPN
fnp-8974	241	64	matschke3	matschke3	PROPN
fnp-8974	241	65	,	,	PUNCT
fnp-8974	241	66	benjamin	benjamin	PROPN
fnp-8974	241	67	ondruschka5	ondruschka5	PROPN
fnp-8974	241	68	,	,	PUNCT
fnp-8974	241	69	marc	marc	PROPN
fnp-8974	241	70	luetgehetmann6	luetgehetmann6	PROPN
fnp-8974	241	71	,	,	PUNCT
fnp-8974	241	72	izabela	izabela	PROPN
fnp-8974	241	73	plumbom2	plumbom2	PROPN
fnp-8974	241	74	,	,	PUNCT
fnp-8974	241	75	janine	janine	PROPN
fnp-8974	241	76	altmüller2	altmüller2	PROPN
fnp-8974	241	77	,	,	PUNCT
fnp-8974	241	78	thomas	thomas	PROPN
fnp-8974	241	79	conrad2	conrad2	PROPN
fnp-8974	241	80	,	,	PUNCT
fnp-8974	241	81	artür	artür	ADJ
fnp-8974	241	82	manukyan2	manukyan2	PROPN
fnp-8974	241	83	,	,	PUNCT
fnp-8974	241	84	altuna	altuna	NOUN
fnp-8974	241	85	akalin2	akalin2	NOUN
fnp-8974	241	86	,	,	PUNCT
fnp-8974	241	87	markus	markus	NOUN
fnp-8974	241	88	landthaler2	landthaler2	PROPN
fnp-8974	241	89	,	,	PUNCT
fnp-8974	241	90	victor	victor	NOUN
fnp-8974	241	91	corman4	corman4	PROPN
fnp-8974	241	92	,	,	PUNCT
fnp-8974	241	93	frank	frank	PROPN
fnp-8974	241	94	heppner1	heppner1	PROPN
fnp-8974	241	95	,	,	PUNCT
fnp-8974	241	96	markus	markus	PROPN
fnp-8974	241	97	glatzel3	glatzel3	PROPN
fnp-8974	241	98	,	,	PUNCT
fnp-8974	241	99	helena	helena	PROPN
fnp-8974	241	100	radbruch1	radbruch1	PROPN
fnp-8974	241	101	,	,	PUNCT
fnp-8974	241	102	susanne	susanne	PROPN
fnp-8974	241	103	krasemann3	krasemann3	PROPN
fnp-8974	241	104	1	1	NUM
fnp-8974	241	105	charité	charité	PROPN
fnp-8974	241	106	university	university	PROPN
fnp-8974	241	107	medicine	medicine	PROPN
fnp-8974	241	108	berlin	berlin	PROPN
fnp-8974	241	109	,	,	PUNCT
fnp-8974	241	110	department	department	NOUN
fnp-8974	241	111	of	of	ADP
fnp-8974	241	112	neuropathology	neuropathology	NOUN
fnp-8974	241	113	,	,	PUNCT
fnp-8974	241	114	berlin	berlin	PROPN
fnp-8974	241	115	,	,	PUNCT
fnp-8974	241	116	germany	germany	PROPN
fnp-8974	241	117	2	2	NUM
fnp-8974	241	118	max	max	PROPN
fnp-8974	241	119	-	-	PUNCT
fnp-8974	241	120	delbrück	delbrück	ADJ
fnp-8974	241	121	-	-	PUNCT
fnp-8974	241	122	center	center	NOUN
fnp-8974	241	123	for	for	ADP
fnp-8974	241	124	molecular	molecular	ADJ
fnp-8974	241	125	medicine	medicine	NOUN
fnp-8974	241	126	in	in	ADP
fnp-8974	241	127	the	the	DET
fnp-8974	241	128	helmholtz	helmholtz	PROPN
fnp-8974	241	129	association	association	PROPN
fnp-8974	241	130	,	,	PUNCT
fnp-8974	241	131	berlin	berlin	PROPN
fnp-8974	241	132	,	,	PUNCT
fnp-8974	241	133	germany	germany	PROPN
fnp-8974	241	134	3	3	NUM
fnp-8974	241	135	university	university	PROPN
fnp-8974	241	136	medical	medical	ADJ
fnp-8974	241	137	center	center	PROPN
fnp-8974	241	138	hamburg	hamburg	PROPN
fnp-8974	241	139	-	-	PUNCT
fnp-8974	241	140	eppendorf	eppendorf	PROPN
fnp-8974	241	141	,	,	PUNCT
fnp-8974	241	142	institute	institute	NOUN
fnp-8974	241	143	of	of	ADP
fnp-8974	241	144	neuropathology	neuropathology	NOUN
fnp-8974	241	145	,	,	PUNCT
fnp-8974	241	146	hamburg	hamburg	PROPN
fnp-8974	241	147	,	,	PUNCT
fnp-8974	241	148	germany	germany	PROPN
fnp-8974	241	149	4	4	NUM
fnp-8974	241	150	charité	charité	PROPN
fnp-8974	241	151	university	university	PROPN
fnp-8974	241	152	medicine	medicine	PROPN
fnp-8974	241	153	berlin	berlin	PROPN
fnp-8974	241	154	,	,	PUNCT
fnp-8974	241	155	institute	institute	NOUN
fnp-8974	241	156	of	of	ADP
fnp-8974	241	157	virology	virology	PROPN
fnp-8974	241	158	,	,	PUNCT
fnp-8974	241	159	berlin	berlin	PROPN
fnp-8974	241	160	,	,	PUNCT
fnp-8974	241	161	germany	germany	PROPN
fnp-8974	241	162	5	5	NUM
fnp-8974	241	163	university	university	PROPN
fnp-8974	241	164	medical	medical	ADJ
fnp-8974	241	165	center	center	PROPN
fnp-8974	241	166	hamburg	hamburg	PROPN
fnp-8974	241	167	-	-	PUNCT
fnp-8974	241	168	eppendorf	eppendorf	PROPN
fnp-8974	241	169	,	,	PUNCT
fnp-8974	241	170	institute	institute	NOUN
fnp-8974	241	171	of	of	ADP
fnp-8974	241	172	legal	legal	ADJ
fnp-8974	241	173	medicine	medicine	NOUN
fnp-8974	241	174	,	,	PUNCT
fnp-8974	241	175	hamburg	hamburg	PROPN
fnp-8974	241	176	,	,	PUNCT
fnp-8974	241	177	germany	germany	PROPN
fnp-8974	241	178	6	6	NUM
fnp-8974	241	179	university	university	PROPN
fnp-8974	241	180	medical	medical	ADJ
fnp-8974	241	181	center	center	PROPN
fnp-8974	241	182	hamburg	hamburg	PROPN
fnp-8974	241	183	-	-	PUNCT
fnp-8974	241	184	eppendorf	eppendorf	PROPN
fnp-8974	241	185	,	,	PUNCT
fnp-8974	241	186	institute	institute	NOUN
fnp-8974	241	187	for	for	ADP
fnp-8974	241	188	medical	medical	ADJ
fnp-8974	241	189	microbiology	microbiology	NOUN
fnp-8974	241	190	,	,	PUNCT
fnp-8974	241	191	hamburg	hamburg	PROPN
fnp-8974	241	192	,	,	PUNCT
fnp-8974	241	193	germany	germany	PROPN
fnp-8974	241	194	7	7	NUM
fnp-8974	241	195	basel	basel	PROPN
fnp-8974	241	196	university	university	PROPN
fnp-8974	241	197	hospital	hospital	NOUN
fnp-8974	241	198	,	,	PUNCT
fnp-8974	241	199	institute	institute	NOUN
fnp-8974	241	200	of	of	ADP
fnp-8974	241	201	pathology	pathology	PROPN
fnp-8974	241	202	,	,	PUNCT
fnp-8974	241	203	basel	basel	PROPN
fnp-8974	241	204	,	,	PUNCT
fnp-8974	241	205	switzerland	switzerland	PROPN
fnp-8974	241	206	8	8	NUM
fnp-8974	241	207	synaptic	synaptic	ADJ
fnp-8974	241	208	systems	system	NOUN
fnp-8974	241	209	gmbh	gmbh	NOUN
fnp-8974	241	210	,	,	PUNCT
fnp-8974	241	211	göttingen	göttingen	PROPN
fnp-8974	241	212	,	,	PUNCT
fnp-8974	241	213	germany	germany	PROPN
fnp-8974	241	214	background	background	NOUN
fnp-8974	241	215	:	:	PUNCT
fnp-8974	241	216	following	follow	VERB
fnp-8974	241	217	initial	initial	ADJ
fnp-8974	241	218	claims	claim	NOUN
fnp-8974	241	219	for	for	ADP
fnp-8974	241	220	viral	viral	ADJ
fnp-8974	241	221	detection	detection	NOUN
fnp-8974	241	222	in	in	ADP
fnp-8974	241	223	cns	cns	NOUN
fnp-8974	241	224	tissue	tissue	NOUN
fnp-8974	241	225	during	during	ADP
fnp-8974	241	226	the	the	DET
fnp-8974	241	227	sars	sar	NOUN
fnp-8974	241	228	-	-	PUNCT
fnp-8974	241	229	cov-2	cov-2	NOUN
fnp-8974	241	230	pandemic	pandemic	ADJ
fnp-8974	241	231	,	,	PUNCT
fnp-8974	241	232	subsequent	subsequent	ADJ
fnp-8974	241	233	studies	study	NOUN
fnp-8974	241	234	revealed	reveal	VERB
fnp-8974	241	235	reduced	reduce	VERB
fnp-8974	241	236	specificity	specificity	NOUN
fnp-8974	241	237	of	of	ADP
fnp-8974	241	238	immunohistological	immunohistological	ADJ
fnp-8974	241	239	stains	stain	NOUN
fnp-8974	241	240	and	and	CCONJ
fnp-8974	241	241	common	common	ADJ
fnp-8974	241	242	misidentification	misidentification	NOUN
fnp-8974	241	243	of	of	ADP
fnp-8974	241	244	cellular	cellular	ADJ
fnp-8974	241	245	structures	structure	NOUN
fnp-8974	241	246	as	as	ADP
fnp-8974	241	247	viral	viral	ADJ
fnp-8974	241	248	in	in	ADP
fnp-8974	241	249	studies	study	NOUN
fnp-8974	241	250	using	use	VERB
fnp-8974	241	251	electron	electron	NOUN
fnp-8974	241	252	microscopy	microscopy	NOUN
fnp-8974	241	253	.	.	PUNCT
fnp-8974	242	1	objective(s	objective(s	NOUN
fnp-8974	242	2	):	):	PUNCT
fnp-8974	242	3	the	the	DET
fnp-8974	242	4	resulting	result	VERB
fnp-8974	242	5	scientific	scientific	ADJ
fnp-8974	242	6	debate	debate	NOUN
fnp-8974	242	7	on	on	ADP
fnp-8974	242	8	viral	viral	ADJ
fnp-8974	242	9	presence	presence	NOUN
fnp-8974	242	10	in	in	ADP
fnp-8974	242	11	the	the	DET
fnp-8974	242	12	cns	cns	PROPN
fnp-8974	242	13	highlights	highlight	NOUN
fnp-8974	242	14	the	the	DET
fnp-8974	242	15	utmost	utmost	ADJ
fnp-8974	242	16	importance	importance	NOUN
fnp-8974	242	17	of	of	ADP
fnp-8974	242	18	robust	robust	ADJ
fnp-8974	242	19	methods	method	NOUN
fnp-8974	242	20	for	for	ADP
fnp-8974	242	21	specific	specific	ADJ
fnp-8974	242	22	detection	detection	NOUN
fnp-8974	242	23	of	of	ADP
fnp-8974	242	24	viral	viral	ADJ
fnp-8974	242	25	products	product	NOUN
fnp-8974	242	26	.	.	PUNCT
fnp-8974	243	1	method(s	method(	VERB
fnp-8974	243	2	):	):	PUNCT
fnp-8974	243	3	in	in	ADP
fnp-8974	243	4	a	a	DET
fnp-8974	243	5	multicenter	multicenter	ADJ
fnp-8974	243	6	approach	approach	NOUN
fnp-8974	243	7	,	,	PUNCT
fnp-8974	243	8	we	we	PRON
fnp-8974	243	9	generated	generate	VERB
fnp-8974	243	10	tissue	tissue	NOUN
fnp-8974	243	11	microarrays	microarray	NOUN
fnp-8974	243	12	containing	contain	VERB
fnp-8974	243	13	380	380	NUM
fnp-8974	243	14	thalamic	thalamic	ADJ
fnp-8974	243	15	and	and	CCONJ
fnp-8974	243	16	cerebellar	cerebellar	ADJ
fnp-8974	243	17	samples	sample	NOUN
fnp-8974	243	18	from	from	ADP
fnp-8974	243	19	donors	donor	NOUN
fnp-8974	243	20	deceased	decease	VERB
fnp-8974	243	21	of	of	ADP
fnp-8974	243	22	covid-19	covid-19	PROPN
fnp-8974	243	23	(	(	PUNCT
fnp-8974	243	24	n	n	CCONJ
fnp-8974	243	25	 	 	SPACE
fnp-8974	243	26	=	=	NOUN
fnp-8974	243	27	 	 	SPACE
fnp-8974	243	28	134	134	NUM
fnp-8974	243	29	)	)	PUNCT
fnp-8974	243	30	and	and	CCONJ
fnp-8974	243	31	age	age	NOUN
fnp-8974	243	32	-	-	PUNCT
fnp-8974	243	33	matched	match	VERB
fnp-8974	243	34	prepandemic	prepandemic	ADJ
fnp-8974	243	35	controls	control	NOUN
fnp-8974	243	36	(	(	PUNCT
fnp-8974	243	37	n	n	CCONJ
fnp-8974	243	38	 	 	SPACE
fnp-8974	243	39	=	=	NOUN
fnp-8974	243	40	 	 	SPACE
fnp-8974	243	41	71	71	NUM
fnp-8974	243	42	)	)	PUNCT
fnp-8974	243	43	.	.	PUNCT
fnp-8974	244	1	sars	sar	NOUN
fnp-8974	244	2	-	-	PUNCT
fnp-8974	244	3	cov-2	cov-2	NOUN
fnp-8974	244	4	transcriptional	transcriptional	ADJ
fnp-8974	244	5	abundance	abundance	NOUN
fnp-8974	244	6	and	and	CCONJ
fnp-8974	244	7	interferon	interferon	ADJ
fnp-8974	244	8	-	-	PUNCT
fnp-8974	244	9	related	relate	VERB
fnp-8974	244	10	gene	gene	NOUN
fnp-8974	244	11	expression	expression	NOUN
fnp-8974	244	12	were	be	AUX
fnp-8974	244	13	analyzed	analyze	VERB
fnp-8974	244	14	using	use	VERB
fnp-8974	244	15	10x	10x	PROPN
fnp-8974	244	16	xenium	xenium	PROPN
fnp-8974	244	17	probe	probe	NOUN
fnp-8974	244	18	-	-	PUNCT
fnp-8974	244	19	based	base	VERB
fnp-8974	244	20	spatial	spatial	ADJ
fnp-8974	244	21	transcriptomics	transcriptomic	NOUN
fnp-8974	244	22	,	,	PUNCT
fnp-8974	244	23	with	with	ADP
fnp-8974	244	24	pulmonary	pulmonary	ADJ
fnp-8974	244	25	tissue	tissue	NOUN
fnp-8974	244	26	of	of	ADP
fnp-8974	244	27	covid-19	covid-19	PROPN
fnp-8974	244	28	donors	donor	NOUN
fnp-8974	244	29	serving	serve	VERB
fnp-8974	244	30	as	as	ADP
fnp-8974	244	31	control	control	NOUN
fnp-8974	244	32	for	for	ADP
fnp-8974	244	33	active	active	ADJ
fnp-8974	244	34	infection	infection	NOUN
fnp-8974	244	35	and	and	CCONJ
fnp-8974	244	36	three	three	NUM
fnp-8974	244	37	hsv1	hsv1	PROPN
fnp-8974	244	38	probes	probe	NOUN
fnp-8974	244	39	serving	serve	VERB
fnp-8974	244	40	as	as	ADP
fnp-8974	244	41	control	control	NOUN
fnp-8974	244	42	for	for	ADP
fnp-8974	244	43	neurotropism	neurotropism	NOUN
fnp-8974	244	44	.	.	PUNCT
fnp-8974	245	1	qpcr	qpcr	ADV
fnp-8974	245	2	and	and	CCONJ
fnp-8974	245	3	immunohistochemistry	immunohistochemistry	VERB
fnp-8974	245	4	on	on	ADP
fnp-8974	245	5	a	a	DET
fnp-8974	245	6	subset	subset	NOUN
fnp-8974	245	7	of	of	ADP
fnp-8974	245	8	samples	sample	NOUN
fnp-8974	245	9	served	serve	VERB
fnp-8974	245	10	as	as	ADP
fnp-8974	245	11	orthogonal	orthogonal	ADJ
fnp-8974	245	12	validation	validation	NOUN
fnp-8974	245	13	.	.	PUNCT
fnp-8974	246	1	result(s	result(s	NOUN
fnp-8974	246	2	):	):	PUNCT
fnp-8974	246	3	pulmonary	pulmonary	ADJ
fnp-8974	246	4	controls	control	NOUN
fnp-8974	246	5	contained	contain	VERB
fnp-8974	246	6	sars	sar	NOUN
fnp-8974	246	7	-	-	PUNCT
fnp-8974	246	8	cov-2	cov-2	NOUN
fnp-8974	246	9	rna	rna	NOUN
fnp-8974	246	10	transcripts	transcript	NOUN
fnp-8974	246	11	,	,	PUNCT
fnp-8974	246	12	and	and	CCONJ
fnp-8974	246	13	brain	brain	NOUN
fnp-8974	246	14	samples	sample	NOUN
fnp-8974	246	15	from	from	ADP
fnp-8974	246	16	one	one	NUM
fnp-8974	246	17	systemically	systemically	ADV
fnp-8974	246	18	hsv1	hsv1	PROPN
fnp-8974	246	19	-	-	PUNCT
fnp-8974	246	20	infected	infect	VERB
fnp-8974	246	21	but	but	CCONJ
fnp-8974	246	22	not	not	PART
fnp-8974	246	23	previously	previously	ADV
fnp-8974	246	24	diagnosed	diagnose	VERB
fnp-8974	246	25	donor	donor	NOUN
fnp-8974	246	26	showed	show	VERB
fnp-8974	246	27	cells	cell	NOUN
fnp-8974	246	28	positive	positive	ADJ
fnp-8974	246	29	for	for	ADP
fnp-8974	246	30	all	all	DET
fnp-8974	246	31	three	three	NUM
fnp-8974	246	32	hsv1	hsv1	PROPN
fnp-8974	246	33	probes	probe	NOUN
fnp-8974	246	34	.	.	PUNCT
fnp-8974	247	1	among	among	ADP
fnp-8974	247	2	all	all	DET
fnp-8974	247	3	other	other	ADJ
fnp-8974	247	4	samples	sample	NOUN
fnp-8974	247	5	,	,	PUNCT
fnp-8974	247	6	significant	significant	ADJ
fnp-8974	247	7	but	but	CCONJ
fnp-8974	247	8	weak	weak	ADJ
fnp-8974	247	9	signal	signal	NOUN
fnp-8974	247	10	for	for	SCONJ
fnp-8974	247	11	both	both	PRON
fnp-8974	247	12	sars	sar	NOUN
fnp-8974	247	13	-	-	PUNCT
fnp-8974	247	14	cov-2	cov-2	PUNCT
fnp-8974	247	15	and	and	CCONJ
fnp-8974	247	16	hsv1	hsv1	PROPN
fnp-8974	247	17	probes	probe	NOUN
fnp-8974	247	18	was	be	AUX
fnp-8974	247	19	restricted	restrict	VERB
fnp-8974	247	20	to	to	ADP
fnp-8974	247	21	granule	granule	VERB
fnp-8974	247	22	cell	cell	NOUN
fnp-8974	247	23	areas	area	NOUN
fnp-8974	247	24	of	of	ADP
fnp-8974	247	25	few	few	ADJ
fnp-8974	247	26	pcr	pcr	ADJ
fnp-8974	247	27	-	-	PUNCT
fnp-8974	247	28	negative	negative	ADJ
fnp-8974	247	29	cerebellar	cerebellar	ADJ
fnp-8974	247	30	samples	sample	NOUN
fnp-8974	247	31	and	and	CCONJ
fnp-8974	247	32	correlated	correlate	VERB
fnp-8974	247	33	closely	closely	ADV
fnp-8974	247	34	with	with	ADP
fnp-8974	247	35	negative	negative	ADJ
fnp-8974	247	36	control	control	NOUN
fnp-8974	247	37	background	background	NOUN
fnp-8974	247	38	.	.	PUNCT
fnp-8974	248	1	interferon	interferon	ADJ
fnp-8974	248	2	-	-	PUNCT
fnp-8974	248	3	related	relate	VERB
fnp-8974	248	4	gene	gene	NOUN
fnp-8974	248	5	expression	expression	NOUN
fnp-8974	248	6	in	in	ADP
fnp-8974	248	7	early	early	ADJ
fnp-8974	248	8	covid-19	covid-19	PROPN
fnp-8974	248	9	brain	brain	NOUN
fnp-8974	248	10	samples	sample	NOUN
fnp-8974	248	11	was	be	AUX
fnp-8974	248	12	elevated	elevate	VERB
fnp-8974	248	13	in	in	ADP
fnp-8974	248	14	comparison	comparison	NOUN
fnp-8974	248	15	to	to	ADP
fnp-8974	248	16	controls	control	NOUN
fnp-8974	248	17	and	and	CCONJ
fnp-8974	248	18	late	late	ADJ
fnp-8974	248	19	covid-19	covid-19	PROPN
fnp-8974	248	20	.	.	PUNCT
fnp-8974	249	1	conclusion(s	conclusion(s	NOUN
fnp-8974	249	2	):	):	PUNCT
fnp-8974	249	3	our	our	PRON
fnp-8974	249	4	results	result	NOUN
fnp-8974	249	5	point	point	VERB
fnp-8974	249	6	to	to	ADP
fnp-8974	249	7	an	an	DET
fnp-8974	249	8	acute	acute	NOUN
fnp-8974	249	9	bystander	bystander	NOUN
fnp-8974	249	10	activation	activation	NOUN
fnp-8974	249	11	of	of	ADP
fnp-8974	249	12	the	the	DET
fnp-8974	249	13	cns	cns	NOUN
fnp-8974	249	14	during	during	ADP
fnp-8974	249	15	systemic	systemic	ADJ
fnp-8974	249	16	covid-19	covid-19	PROPN
fnp-8974	249	17	infection	infection	NOUN
fnp-8974	249	18	,	,	PUNCT
fnp-8974	249	19	rather	rather	ADV
fnp-8974	249	20	than	than	ADP
fnp-8974	249	21	true	true	ADJ
fnp-8974	249	22	neurotropism	neurotropism	NOUN
fnp-8974	249	23	of	of	ADP
fnp-8974	249	24	sars	sar	NOUN
fnp-8974	249	25	-	-	PUNCT
fnp-8974	249	26	cov-2	cov-2	NOUN
fnp-8974	249	27	.	.	PUNCT
fnp-8974	250	1	they	they	PRON
fnp-8974	250	2	highlight	highlight	VERB
fnp-8974	250	3	the	the	DET
fnp-8974	250	4	importance	importance	NOUN
fnp-8974	250	5	of	of	ADP
fnp-8974	250	6	using	use	VERB
fnp-8974	250	7	orthogonal	orthogonal	ADJ
fnp-8974	250	8	methods	method	NOUN
fnp-8974	250	9	for	for	ADP
fnp-8974	250	10	viral	viral	ADJ
fnp-8974	250	11	detection	detection	NOUN
fnp-8974	250	12	.	.	PUNCT
fnp-8974	251	1	p19	p19	VERB
fnp-8974	251	2	free	free	ADJ
fnp-8974	251	3	neuropathol	neuropathol	NOUN
fnp-8974	252	1	6:17:31	6:17:31	NUM
fnp-8974	252	2	neuropathological	neuropathological	ADJ
fnp-8974	252	3	characteristics	characteristic	NOUN
fnp-8974	252	4	of	of	ADP
fnp-8974	252	5	anti	anti	ADJ
fnp-8974	252	6	-	-	ADJ
fnp-8974	252	7	gaba	gaba	ADJ
fnp-8974	252	8	-	-	PUNCT
fnp-8974	252	9	b	b	NOUN
fnp-8974	252	10	-	-	PUNCT
fnp-8974	252	11	receptor	receptor	NOUN
fnp-8974	252	12	-	-	PUNCT
fnp-8974	252	13	encephalitis	encephalitis	NOUN
fnp-8974	252	14	valérie	valérie	NOUN
fnp-8974	252	15	quinot1,2	quinot1,2	PROPN
fnp-8974	252	16	,	,	PUNCT
fnp-8974	252	17	verena	verena	PROPN
fnp-8974	252	18	endmayr1,2	endmayr1,2	PROPN
fnp-8974	252	19	,	,	PUNCT
fnp-8974	252	20	jordi	jordi	PROPN
fnp-8974	252	21	estela	estela	PROPN
fnp-8974	252	22	-	-	PUNCT
fnp-8974	252	23	herrero3	herrero3	PROPN
fnp-8974	252	24	,	,	PUNCT
fnp-8974	252	25	mar	mar	PROPN
fnp-8974	252	26	guasp4,5,6	guasp4,5,6	PROPN
fnp-8974	252	27	,	,	PUNCT
fnp-8974	252	28	ellen	ellen	PROPN
fnp-8974	252	29	gelpi1,2	gelpi1,2	PROPN
fnp-8974	252	30	,	,	PUNCT
fnp-8974	252	31	jan	jan	PROPN
fnp-8974	252	32	bauer7	bauer7	PROPN
fnp-8974	252	33	,	,	PUNCT
fnp-8974	252	34	michael	michael	PROPN
fnp-8974	252	35	winklehner8	winklehner8	PROPN
fnp-8974	252	36	,	,	PUNCT
fnp-8974	252	37	serge	serge	PROPN
fnp-8974	252	38	weiss9	weiss9	PROPN
fnp-8974	252	39	,	,	PUNCT
fnp-8974	252	40	romana	romana	PROPN
fnp-8974	252	41	höftberger1,2	höftberger1,2	PROPN
fnp-8974	252	42	1	1	NUM
fnp-8974	252	43	division	division	NOUN
fnp-8974	252	44	of	of	ADP
fnp-8974	252	45	neuropathology	neuropathology	NOUN
fnp-8974	252	46	and	and	CCONJ
fnp-8974	252	47	neurochemistry	neurochemistry	NOUN
fnp-8974	252	48	,	,	PUNCT
fnp-8974	252	49	department	department	NOUN
fnp-8974	252	50	of	of	ADP
fnp-8974	252	51	neurology	neurology	NOUN
fnp-8974	252	52	,	,	PUNCT
fnp-8974	252	53	medical	medical	ADJ
fnp-8974	252	54	university	university	PROPN
fnp-8974	252	55	of	of	ADP
fnp-8974	252	56	vienna	vienna	PROPN
fnp-8974	252	57	,	,	PUNCT
fnp-8974	252	58	vienna	vienna	PROPN
fnp-8974	252	59	,	,	PUNCT
fnp-8974	252	60	austria	austria	PROPN
fnp-8974	252	61	2	2	NUM
fnp-8974	252	62	comprehensive	comprehensive	ADJ
fnp-8974	252	63	center	center	NOUN
fnp-8974	252	64	for	for	ADP
fnp-8974	252	65	clinical	clinical	ADJ
fnp-8974	252	66	neurosciences	neuroscience	NOUN
fnp-8974	252	67	and	and	CCONJ
fnp-8974	252	68	mental	mental	ADJ
fnp-8974	252	69	health	health	NOUN
fnp-8974	252	70	,	,	PUNCT
fnp-8974	252	71	medical	medical	ADJ
fnp-8974	252	72	university	university	PROPN
fnp-8974	252	73	of	of	ADP
fnp-8974	252	74	vienna	vienna	PROPN
fnp-8974	252	75	,	,	PUNCT
fnp-8974	252	76	vienna	vienna	PROPN
fnp-8974	252	77	,	,	PUNCT
fnp-8974	252	78	austria	austria	PROPN
fnp-8974	252	79	3	3	NUM
fnp-8974	252	80	neurology	neurology	NOUN
fnp-8974	252	81	service	service	NOUN
fnp-8974	252	82	,	,	PUNCT
fnp-8974	252	83	hospital	hospital	NOUN
fnp-8974	252	84	parc	parc	PROPN
fnp-8974	252	85	taulí	taulí	PROPN
fnp-8974	252	86	,	,	PUNCT
fnp-8974	252	87	sabadell	sabadell	PROPN
fnp-8974	252	88	,	,	PUNCT
fnp-8974	252	89	spain	spain	PROPN
fnp-8974	252	90	4	4	NUM
fnp-8974	252	91	hospital	hospital	NOUN
fnp-8974	252	92	clínic	clínic	PROPN
fnp-8974	252	93	de	de	PROPN
fnp-8974	252	94	barcelona	barcelona	PROPN
fnp-8974	252	95	,	,	PUNCT
fnp-8974	252	96	university	university	PROPN
fnp-8974	252	97	of	of	ADP
fnp-8974	252	98	barcelona	barcelona	PROPN
fnp-8974	252	99	,	,	PUNCT
fnp-8974	252	100	barcelona	barcelona	PROPN
fnp-8974	252	101	,	,	PUNCT
fnp-8974	252	102	neuroimmunology	neuroimmunology	NOUN
fnp-8974	252	103	unit	unit	NOUN
fnp-8974	252	104	,	,	PUNCT
fnp-8974	252	105	department	department	PROPN
fnp-8974	252	106	of	of	ADP
fnp-8974	252	107	neurology	neurology	NOUN
fnp-8974	252	108	,	,	PUNCT
fnp-8974	252	109	barcelona	barcelona	PROPN
fnp-8974	252	110	,	,	PUNCT
fnp-8974	252	111	spain	spain	PROPN
fnp-8974	252	112	5	5	NUM
fnp-8974	252	113	institut	institut	PROPN
fnp-8974	252	114	d’investigacions	d’investigacion	NOUN
fnp-8974	252	115	biomèdiques	biomèdique	VERB
fnp-8974	252	116	august	august	PROPN
fnp-8974	252	117	pi	pi	NOUN
fnp-8974	253	1	i	i	PRON
fnp-8974	253	2	sunyer	sunyer	NOUN
fnp-8974	253	3	(	(	PUNCT
fnp-8974	253	4	idibaps)-caixa	idibaps)-caixa	NOUN
fnp-8974	253	5	research	research	PROPN
fnp-8974	253	6	institute	institute	PROPN
fnp-8974	253	7	,	,	PUNCT
fnp-8974	253	8	barcelona	barcelona	PROPN
fnp-8974	253	9	,	,	PUNCT
fnp-8974	253	10	spain	spain	PROPN
fnp-8974	253	11	6	6	NUM
fnp-8974	253	12	centro	centro	X
fnp-8974	253	13	de	de	PROPN
fnp-8974	253	14	investigación	investigación	PROPN
fnp-8974	253	15	biomédica	biomédica	PROPN
fnp-8974	253	16	en	en	PROPN
fnp-8974	253	17	red	red	PROPN
fnp-8974	253	18	,	,	PUNCT
fnp-8974	253	19	enfermedades	enfermedade	NOUN
fnp-8974	253	20	raras	raras	NOUN
fnp-8974	253	21	(	(	PUNCT
fnp-8974	253	22	ciberer	ciberer	NOUN
fnp-8974	253	23	)	)	PUNCT
fnp-8974	253	24	,	,	PUNCT
fnp-8974	253	25	madrid	madrid	PROPN
fnp-8974	253	26	,	,	PUNCT
fnp-8974	253	27	spain	spain	PROPN
fnp-8974	253	28	7	7	NUM
fnp-8974	253	29	department	department	PROPN
fnp-8974	253	30	of	of	ADP
fnp-8974	253	31	neuroimmunology	neuroimmunology	NOUN
fnp-8974	253	32	,	,	PUNCT
fnp-8974	253	33	center	center	NOUN
fnp-8974	253	34	for	for	ADP
fnp-8974	253	35	brain	brain	NOUN
fnp-8974	253	36	research	research	NOUN
fnp-8974	253	37	,	,	PUNCT
fnp-8974	253	38	medical	medical	ADJ
fnp-8974	253	39	university	university	PROPN
fnp-8974	253	40	of	of	ADP
fnp-8974	253	41	vienna	vienna	PROPN
fnp-8974	253	42	,	,	PUNCT
fnp-8974	253	43	vienna	vienna	PROPN
fnp-8974	253	44	,	,	PUNCT
fnp-8974	253	45	austria	austria	PROPN
fnp-8974	253	46	8	8	NUM
fnp-8974	253	47	johannes	johannes	PROPN
fnp-8974	253	48	kepler	kepler	PROPN
fnp-8974	253	49	university	university	PROPN
fnp-8974	253	50	linz	linz	PROPN
fnp-8974	253	51	,	,	PUNCT
fnp-8974	253	52	kepler	kepler	PROPN
fnp-8974	253	53	university	university	PROPN
fnp-8974	253	54	hospital	hospital	NOUN
fnp-8974	253	55	,	,	PUNCT
fnp-8974	253	56	department	department	NOUN
fnp-8974	253	57	of	of	ADP
fnp-8974	253	58	neurology	neurology	NOUN
fnp-8974	253	59	,	,	PUNCT
fnp-8974	253	60	linz	linz	PROPN
fnp-8974	253	61	,	,	PUNCT
fnp-8974	253	62	austria	austria	PROPN
fnp-8974	253	63	9	9	NUM
fnp-8974	253	64	kepler	kepler	PROPN
fnp-8974	253	65	university	university	NOUN
fnp-8974	253	66	hospital	hospital	NOUN
fnp-8974	253	67	,	,	PUNCT
fnp-8974	253	68	johannes	johannes	PROPN
fnp-8974	253	69	kepler	kepler	PROPN
fnp-8974	253	70	university	university	PROPN
fnp-8974	253	71	,	,	PUNCT
fnp-8974	253	72	department	department	NOUN
fnp-8974	253	73	of	of	ADP
fnp-8974	253	74	pathology	pathology	NOUN
fnp-8974	253	75	and	and	CCONJ
fnp-8974	253	76	molecular	molecular	ADJ
fnp-8974	253	77	pathology	pathology	NOUN
fnp-8974	253	78	,	,	PUNCT
fnp-8974	253	79	neuromed	neuromed	PROPN
fnp-8974	253	80	campus	campus	PROPN
fnp-8974	253	81	,	,	PUNCT
fnp-8974	253	82	division	division	NOUN
fnp-8974	253	83	of	of	ADP
fnp-8974	253	84	neuropathology	neuropathology	NOUN
fnp-8974	253	85	,	,	PUNCT
fnp-8974	253	86	linz	linz	PROPN
fnp-8974	253	87	,	,	PUNCT
fnp-8974	253	88	austria	austria	PROPN
fnp-8974	253	89	background	background	NOUN
fnp-8974	253	90	:	:	PUNCT
fnp-8974	253	91	antibodies	antibodie	VERB
fnp-8974	253	92	(	(	PUNCT
fnp-8974	253	93	ab	ab	X
fnp-8974	253	94	)	)	PUNCT
fnp-8974	253	95	targeting	target	VERB
fnp-8974	253	96	the	the	DET
fnp-8974	253	97	γ	γ	NOUN
fnp-8974	253	98	-	-	ADJ
fnp-8974	253	99	aminobutyric	aminobutyric	ADJ
fnp-8974	253	100	acid	acid	NOUN
fnp-8974	253	101	type	type	NOUN
fnp-8974	253	102	b	b	NOUN
fnp-8974	253	103	receptor	receptor	NOUN
fnp-8974	253	104	(	(	PUNCT
fnp-8974	253	105	gababr	gababr	NOUN
fnp-8974	253	106	)	)	PUNCT
fnp-8974	253	107	lead	lead	NOUN
fnp-8974	253	108	to	to	ADP
fnp-8974	253	109	symptoms	symptom	NOUN
fnp-8974	253	110	associated	associate	VERB
fnp-8974	253	111	with	with	ADP
fnp-8974	253	112	limbic	limbic	ADJ
fnp-8974	253	113	encephalitis	encephalitis	NOUN
fnp-8974	253	114	,	,	PUNCT
fnp-8974	253	115	including	include	VERB
fnp-8974	253	116	seizures	seizure	NOUN
fnp-8974	253	117	,	,	PUNCT
fnp-8974	253	118	memory	memory	NOUN
fnp-8974	253	119	loss	loss	NOUN
fnp-8974	253	120	and	and	CCONJ
fnp-8974	253	121	confusion	confusion	NOUN
fnp-8974	253	122	.	.	PUNCT
fnp-8974	254	1	50	50	NUM
fnp-8974	254	2	 	 	SPACE
fnp-8974	254	3	%	%	NOUN
fnp-8974	254	4	of	of	ADP
fnp-8974	254	5	patients	patient	NOUN
fnp-8974	254	6	have	have	VERB
fnp-8974	254	7	underlying	underlie	VERB
fnp-8974	254	8	small	small	ADJ
fnp-8974	254	9	-	-	PUNCT
fnp-8974	254	10	cell	cell	NOUN
fnp-8974	254	11	lung	lung	NOUN
fnp-8974	254	12	cancer	cancer	NOUN
fnp-8974	254	13	(	(	PUNCT
fnp-8974	254	14	sclc	sclc	PROPN
fnp-8974	254	15	)	)	PUNCT
fnp-8974	254	16	.	.	PUNCT
fnp-8974	255	1	recently	recently	ADV
fnp-8974	255	2	,	,	PUNCT
fnp-8974	255	3	ab	ab	PROPN
fnp-8974	255	4	directed	direct	VERB
fnp-8974	255	5	against	against	ADP
fnp-8974	255	6	the	the	DET
fnp-8974	255	7	potassium	potassium	NOUN
fnp-8974	255	8	channel	channel	NOUN
fnp-8974	255	9	tetramerization	tetramerization	NOUN
fnp-8974	255	10	domain	domain	NOUN
fnp-8974	255	11	-	-	PUNCT
fnp-8974	255	12	containing	contain	VERB
fnp-8974	255	13	(	(	PUNCT
fnp-8974	255	14	kctd	kctd	NOUN
fnp-8974	255	15	)	)	PUNCT
fnp-8974	255	16	protein	protein	NOUN
fnp-8974	255	17	16	16	NUM
fnp-8974	255	18	,	,	PUNCT
fnp-8974	255	19	accessory	accessory	NOUN
fnp-8974	255	20	to	to	ADP
fnp-8974	255	21	the	the	DET
fnp-8974	255	22	gababr	gababr	NOUN
fnp-8974	255	23	-	-	PUNCT
fnp-8974	255	24	complex	complex	NOUN
fnp-8974	255	25	,	,	PUNCT
fnp-8974	255	26	have	have	AUX
fnp-8974	255	27	been	be	AUX
fnp-8974	255	28	associated	associate	VERB
fnp-8974	255	29	with	with	ADP
fnp-8974	255	30	paraneoplastic	paraneoplastic	ADJ
fnp-8974	255	31	anti	anti	ADJ
fnp-8974	255	32	-	-	ADJ
fnp-8974	255	33	gababr	gababr	ADJ
fnp-8974	255	34	-	-	PUNCT
fnp-8974	255	35	encephalitis	encephalitis	NOUN
fnp-8974	255	36	with	with	ADP
fnp-8974	255	37	sclc	sclc	PROPN
fnp-8974	255	38	.	.	PUNCT
fnp-8974	256	1	objective(s	objective(s	NOUN
fnp-8974	256	2	):	):	PUNCT
fnp-8974	256	3	to	to	PART
fnp-8974	256	4	characterize	characterize	VERB
fnp-8974	256	5	the	the	DET
fnp-8974	256	6	type	type	NOUN
fnp-8974	256	7	and	and	CCONJ
fnp-8974	256	8	topographic	topographic	ADJ
fnp-8974	256	9	distribution	distribution	NOUN
fnp-8974	256	10	of	of	ADP
fnp-8974	256	11	cellular	cellular	ADJ
fnp-8974	256	12	and	and	CCONJ
fnp-8974	256	13	humoral	humoral	ADJ
fnp-8974	256	14	inflammatory	inflammatory	ADJ
fnp-8974	256	15	response	response	NOUN
fnp-8974	256	16	in	in	ADP
fnp-8974	256	17	post	post	ADJ
fnp-8974	256	18	-	-	ADJ
fnp-8974	256	19	mortem	mortem	ADJ
fnp-8974	256	20	brains	brain	NOUN
fnp-8974	256	21	and	and	CCONJ
fnp-8974	256	22	to	to	PART
fnp-8974	256	23	correlate	correlate	VERB
fnp-8974	256	24	the	the	DET
fnp-8974	256	25	findings	finding	NOUN
fnp-8974	256	26	with	with	ADP
fnp-8974	256	27	clinical	clinical	ADJ
fnp-8974	256	28	data	datum	NOUN
fnp-8974	256	29	.	.	PUNCT
fnp-8974	257	1	method(s	method(	VERB
fnp-8974	257	2	):	):	PUNCT
fnp-8974	257	3	histological	histological	ADJ
fnp-8974	257	4	and	and	CCONJ
fnp-8974	257	5	immunohistochemical	immunohistochemical	ADJ
fnp-8974	257	6	evaluation	evaluation	NOUN
fnp-8974	257	7	of	of	ADP
fnp-8974	257	8	4	4	NUM
fnp-8974	257	9	archival	archival	NOUN
fnp-8974	257	10	brain	brain	NOUN
fnp-8974	257	11	autopsies	autopsy	NOUN
fnp-8974	257	12	from	from	ADP
fnp-8974	257	13	patients	patient	NOUN
fnp-8974	257	14	with	with	ADP
fnp-8974	257	15	anti	anti	ADJ
fnp-8974	257	16	-	-	ADJ
fnp-8974	257	17	gababr	gababr	ADJ
fnp-8974	257	18	-	-	PUNCT
fnp-8974	257	19	encephalitis	encephalitis	NOUN
fnp-8974	257	20	.	.	PUNCT
fnp-8974	258	1	determination	determination	NOUN
fnp-8974	258	2	of	of	ADP
fnp-8974	258	3	serum	serum	NOUN
fnp-8974	258	4	-	-	PUNCT
fnp-8974	258	5	anti	anti	ADJ
fnp-8974	258	6	-	-	ADJ
fnp-8974	258	7	kctd16	kctd16	ADJ
fnp-8974	258	8	-	-	PUNCT
fnp-8974	258	9	ab	ab	NOUN
fnp-8974	258	10	-	-	PUNCT
fnp-8974	258	11	status	status	NOUN
fnp-8974	258	12	by	by	ADP
fnp-8974	258	13	cba	cba	PROPN
fnp-8974	258	14	.	.	PUNCT
fnp-8974	259	1	result(s	result(s	PROPN
fnp-8974	259	2	):	):	PUNCT
fnp-8974	259	3	neurological	neurological	ADJ
fnp-8974	259	4	symptoms	symptom	NOUN
fnp-8974	259	5	of	of	ADP
fnp-8974	259	6	the	the	DET
fnp-8974	259	7	4	4	NUM
fnp-8974	259	8	patients	patient	NOUN
fnp-8974	259	9	(	(	PUNCT
fnp-8974	259	10	4	4	NUM
fnp-8974	259	11	males	male	NOUN
fnp-8974	259	12	,	,	PUNCT
fnp-8974	259	13	mean	mean	ADJ
fnp-8974	259	14	age	age	NOUN
fnp-8974	259	15	of	of	ADP
fnp-8974	259	16	74a	74a	NOUN
fnp-8974	259	17	)	)	PUNCT
fnp-8974	259	18	included	include	VERB
fnp-8974	259	19	epileptic	epileptic	ADJ
fnp-8974	259	20	seizures	seizure	NOUN
fnp-8974	259	21	(	(	PUNCT
fnp-8974	259	22	n	n	CCONJ
fnp-8974	259	23	 	 	SPACE
fnp-8974	259	24	=	=	NOUN
fnp-8974	259	25	 	 	SPACE
fnp-8974	259	26	2	2	NUM
fnp-8974	259	27	)	)	PUNCT
fnp-8974	259	28	,	,	PUNCT
fnp-8974	259	29	dysarthria	dysarthria	NOUN
fnp-8974	259	30	(	(	PUNCT
fnp-8974	259	31	n	n	CCONJ
fnp-8974	259	32	 	 	SPACE
fnp-8974	259	33	=	=	NOUN
fnp-8974	259	34	 	 	SPACE
fnp-8974	259	35	1	1	NUM
fnp-8974	259	36	)	)	PUNCT
fnp-8974	259	37	,	,	PUNCT
fnp-8974	259	38	dysphagia	dysphagia	NOUN
fnp-8974	259	39	(	(	PUNCT
fnp-8974	259	40	n	n	CCONJ
fnp-8974	259	41	 	 	SPACE
fnp-8974	259	42	=	=	NOUN
fnp-8974	259	43	 	 	SPACE
fnp-8974	259	44	1	1	NUM
fnp-8974	259	45	)	)	PUNCT
fnp-8974	259	46	,	,	PUNCT
fnp-8974	259	47	and	and	CCONJ
fnp-8974	259	48	vertigo	vertigo	NOUN
fnp-8974	259	49	(	(	PUNCT
fnp-8974	259	50	n	n	CCONJ
fnp-8974	259	51	 	 	SPACE
fnp-8974	259	52	=	=	NOUN
fnp-8974	259	53	 	 	SPACE
fnp-8974	259	54	1	1	NUM
fnp-8974	259	55	)	)	PUNCT
fnp-8974	259	56	.	.	PUNCT
fnp-8974	260	1	1	1	NUM
fnp-8974	260	2	patient	patient	NOUN
fnp-8974	260	3	had	have	VERB
fnp-8974	260	4	sclc	sclc	PROPN
fnp-8974	260	5	.	.	PUNCT
fnp-8974	261	1	on	on	ADP
fnp-8974	261	2	histology	histology	NOUN
fnp-8974	261	3	,	,	PUNCT
fnp-8974	261	4	mild	mild	ADJ
fnp-8974	261	5	to	to	ADP
fnp-8974	261	6	moderate	moderate	ADJ
fnp-8974	261	7	cd8	cd8	PROPN
fnp-8974	261	8	+	+	PROPN
fnp-8974	261	9	t	t	PROPN
fnp-8974	261	10	-	-	PUNCT
fnp-8974	261	11	cell	cell	NOUN
fnp-8974	261	12	-	-	PUNCT
fnp-8974	261	13	dominated	dominate	VERB
fnp-8974	261	14	parenchymal	parenchymal	ADJ
fnp-8974	261	15	and	and	CCONJ
fnp-8974	261	16	perivascular	perivascular	ADJ
fnp-8974	261	17	inflammation	inflammation	NOUN
fnp-8974	261	18	in	in	ADP
fnp-8974	261	19	the	the	DET
fnp-8974	261	20	patient	patient	NOUN
fnp-8974	261	21	with	with	ADP
fnp-8974	261	22	positive	positive	ADJ
fnp-8974	261	23	anti	anti	ADJ
fnp-8974	261	24	-	-	ADJ
fnp-8974	261	25	kctd16	kctd16	ADJ
fnp-8974	261	26	-	-	PUNCT
fnp-8974	261	27	ab	ab	NOUN
fnp-8974	261	28	-	-	PUNCT
fnp-8974	261	29	status	status	NOUN
fnp-8974	261	30	,	,	PUNCT
fnp-8974	261	31	and	and	CCONJ
fnp-8974	261	32	a	a	DET
fnp-8974	261	33	smaller	small	ADJ
fnp-8974	261	34	fraction	fraction	NOUN
fnp-8974	261	35	of	of	ADP
fnp-8974	261	36	cd79	cd79	PROPN
fnp-8974	261	37	+	+	CCONJ
fnp-8974	261	38	b	b	NOUN
fnp-8974	261	39	-	-	PUNCT
fnp-8974	261	40	cells	cell	NOUN
fnp-8974	261	41	/	/	SYM
fnp-8974	261	42	plasma	plasma	NOUN
fnp-8974	261	43	cells	cell	NOUN
fnp-8974	261	44	was	be	AUX
fnp-8974	261	45	observed	observe	VERB
fnp-8974	261	46	in	in	ADP
fnp-8974	261	47	amygdala	amygdala	NOUN
fnp-8974	261	48	,	,	PUNCT
fnp-8974	261	49	hippocampus	hippocampus	NOUN
fnp-8974	261	50	,	,	PUNCT
fnp-8974	261	51	and	and	CCONJ
fnp-8974	261	52	cingulate	cingulate	NOUN
fnp-8974	261	53	gyrus	gyrus	NOUN
fnp-8974	261	54	compatible	compatible	ADJ
fnp-8974	261	55	with	with	ADP
fnp-8974	261	56	predominantly	predominantly	ADV
fnp-8974	261	57	limbic	limbic	ADJ
fnp-8974	261	58	encephalitis	encephalitis	NOUN
fnp-8974	261	59	,	,	PUNCT
fnp-8974	261	60	followed	follow	VERB
fnp-8974	261	61	by	by	ADP
fnp-8974	261	62	inflammation	inflammation	NOUN
fnp-8974	261	63	in	in	ADP
fnp-8974	261	64	brainstem	brainstem	NOUN
fnp-8974	261	65	and	and	CCONJ
fnp-8974	261	66	basal	basal	ADJ
fnp-8974	261	67	ganglia	ganglia	NOUN
fnp-8974	261	68	in	in	ADP
fnp-8974	261	69	all	all	DET
fnp-8974	261	70	patients	patient	NOUN
fnp-8974	261	71	.	.	PUNCT
fnp-8974	262	1	microglia	microglia	ADJ
fnp-8974	262	2	profile	profile	NOUN
fnp-8974	262	3	was	be	AUX
fnp-8974	262	4	consistently	consistently	ADV
fnp-8974	262	5	proinflammatory	proinflammatory	ADJ
fnp-8974	262	6	(	(	PUNCT
fnp-8974	262	7	hla	hla	NOUN
fnp-8974	262	8	-	-	PUNCT
fnp-8974	262	9	dr+	dr+	NOUN
fnp-8974	262	10	,	,	PUNCT
fnp-8974	262	11	p22phox+	p22phox+	NOUN
fnp-8974	262	12	)	)	PUNCT
fnp-8974	262	13	.	.	PUNCT
fnp-8974	263	1	one	one	NUM
fnp-8974	263	2	patient	patient	NOUN
fnp-8974	263	3	showed	show	VERB
fnp-8974	263	4	bilateral	bilateral	ADJ
fnp-8974	263	5	hippocampal	hippocampal	ADJ
fnp-8974	263	6	sclerosis	sclerosis	NOUN
fnp-8974	263	7	,	,	PUNCT
fnp-8974	263	8	while	while	SCONJ
fnp-8974	263	9	unilateral	unilateral	ADJ
fnp-8974	263	10	hippocampal	hippocampal	ADJ
fnp-8974	263	11	sclerosis	sclerosis	NOUN
fnp-8974	263	12	was	be	AUX
fnp-8974	263	13	identified	identify	VERB
fnp-8974	263	14	in	in	ADP
fnp-8974	263	15	2/4	2/4	NUM
fnp-8974	263	16	patients	patient	NOUN
fnp-8974	263	17	.	.	PUNCT
fnp-8974	264	1	two	two	NUM
fnp-8974	264	2	patients	patient	NOUN
fnp-8974	264	3	showed	show	VERB
fnp-8974	264	4	combined	combined	ADJ
fnp-8974	264	5	neurodegenerative	neurodegenerative	ADJ
fnp-8974	264	6	proteinopathies	proteinopathie	NOUN
fnp-8974	264	7	.	.	PUNCT
fnp-8974	265	1	conclusion(s	conclusion(s	NOUN
fnp-8974	265	2	):	):	PUNCT
fnp-8974	265	3	our	our	PRON
fnp-8974	265	4	results	result	NOUN
fnp-8974	265	5	indicate	indicate	VERB
fnp-8974	265	6	a	a	DET
fnp-8974	265	7	t	t	NOUN
fnp-8974	265	8	-	-	PUNCT
fnp-8974	265	9	cell	cell	NOUN
fnp-8974	265	10	-	-	PUNCT
fnp-8974	265	11	inflammatory	inflammatory	ADJ
fnp-8974	265	12	component	component	NOUN
fnp-8974	265	13	in	in	ADP
fnp-8974	265	14	addition	addition	NOUN
fnp-8974	265	15	to	to	ADP
fnp-8974	265	16	an	an	DET
fnp-8974	265	17	ab	ab	ADJ
fnp-8974	265	18	-	-	PUNCT
fnp-8974	265	19	mediated	mediate	VERB
fnp-8974	265	20	pathophysiology	pathophysiology	NOUN
fnp-8974	265	21	in	in	ADP
fnp-8974	265	22	anti	anti	ADJ
fnp-8974	265	23	-	-	ADJ
fnp-8974	265	24	gababr	gababr	ADJ
fnp-8974	265	25	-	-	PUNCT
fnp-8974	265	26	encephalitis	encephalitis	NOUN
fnp-8974	265	27	,	,	PUNCT
fnp-8974	265	28	which	which	PRON
fnp-8974	265	29	may	may	AUX
fnp-8974	265	30	be	be	AUX
fnp-8974	265	31	more	more	ADV
fnp-8974	265	32	pronounced	pronounce	VERB
fnp-8974	265	33	in	in	ADP
fnp-8974	265	34	the	the	DET
fnp-8974	265	35	paraneoplastic	paraneoplastic	ADJ
fnp-8974	265	36	form	form	NOUN
fnp-8974	265	37	associated	associate	VERB
fnp-8974	265	38	with	with	ADP
fnp-8974	265	39	sclc	sclc	PROPN
fnp-8974	265	40	and	and	CCONJ
fnp-8974	265	41	anti	anti	ADJ
fnp-8974	265	42	-	-	ADJ
fnp-8974	265	43	kctd16	kctd16	ADJ
fnp-8974	265	44	-	-	PUNCT
fnp-8974	265	45	ab	ab	PROPN
fnp-8974	265	46	.	.	PROPN
fnp-8974	265	47	p20	p20	PROPN
fnp-8974	265	48	free	free	ADJ
fnp-8974	265	49	neuropathol	neuropathol	NOUN
fnp-8974	265	50	6:17:33	6:17:33	NUM
fnp-8974	265	51	impact	impact	NOUN
fnp-8974	265	52	of	of	ADP
fnp-8974	265	53	myelin	myelin	ADJ
fnp-8974	265	54	phagocytosis	phagocytosis	NOUN
fnp-8974	265	55	on	on	ADP
fnp-8974	265	56	human	human	ADJ
fnp-8974	265	57	blood	blood	NOUN
fnp-8974	265	58	-	-	PUNCT
fnp-8974	265	59	derived	derive	VERB
fnp-8974	265	60	macrophages	macrophage	NOUN
fnp-8974	265	61	and	and	CCONJ
fnp-8974	265	62	microglia	microglia	NOUN
fnp-8974	265	63	and	and	CCONJ
fnp-8974	265	64	its	its	PRON
fnp-8974	265	65	effect	effect	NOUN
fnp-8974	265	66	on	on	ADP
fnp-8974	265	67	human	human	ADJ
fnp-8974	265	68	oligodendrocytes	oligodendrocyte	NOUN
fnp-8974	265	69	laura	laura	PROPN
fnp-8974	265	70	schmitz	schmitz	PROPN
fnp-8974	265	71	-	-	PUNCT
fnp-8974	265	72	gielsdorf1	gielsdorf1	PROPN
fnp-8974	265	73	,	,	PUNCT
fnp-8974	265	74	katharina	katharina	PROPN
fnp-8974	265	75	heß1	heß1	PROPN
fnp-8974	265	76	,	,	PUNCT
fnp-8974	265	77	marie	marie	PROPN
fnp-8974	265	78	-	-	PUNCT
fnp-8974	265	79	france	france	PROPN
fnp-8974	265	80	dorion2	dorion2	NOUN
fnp-8974	265	81	,	,	PUNCT
fnp-8974	265	82	jack	jack	PROPN
fnp-8974	265	83	antel2	antel2	PROPN
fnp-8974	265	84	,	,	PUNCT
fnp-8974	265	85	inge	inge	PROPN
fnp-8974	265	86	huitinga3	huitinga3	PROPN
fnp-8974	265	87	,	,	PUNCT
fnp-8974	265	88	luisa	luisa	PROPN
fnp-8974	265	89	klotz4	klotz4	PROPN
fnp-8974	265	90	,	,	PUNCT
fnp-8974	265	91	tanja	tanja	PROPN
fnp-8974	265	92	kuhlmann1	kuhlmann1	PROPN
fnp-8974	265	93	1	1	NUM
fnp-8974	265	94	institute	institute	PROPN
fnp-8974	265	95	of	of	ADP
fnp-8974	265	96	neuropathology	neuropathology	NOUN
fnp-8974	265	97	,	,	PUNCT
fnp-8974	265	98	university	university	NOUN
fnp-8974	265	99	hospital	hospital	NOUN
fnp-8974	265	100	münster	münster	NOUN
fnp-8974	265	101	,	,	PUNCT
fnp-8974	265	102	münster	münster	PROPN
fnp-8974	265	103	,	,	PUNCT
fnp-8974	265	104	germany	germany	PROPN
fnp-8974	265	105	2	2	NUM
fnp-8974	265	106	montreal	montreal	PROPN
fnp-8974	265	107	neurological	neurological	PROPN
fnp-8974	265	108	institute	institute	PROPN
fnp-8974	265	109	,	,	PUNCT
fnp-8974	265	110	neuroimmunology	neuroimmunology	NOUN
fnp-8974	265	111	unit	unit	NOUN
fnp-8974	265	112	,	,	PUNCT
fnp-8974	265	113	quebec	quebec	PROPN
fnp-8974	265	114	,	,	PUNCT
fnp-8974	265	115	canada	canada	PROPN
fnp-8974	265	116	3	3	NUM
fnp-8974	265	117	netherlands	netherlands	PROPN
fnp-8974	265	118	institute	institute	PROPN
fnp-8974	265	119	for	for	ADP
fnp-8974	265	120	neuroscience	neuroscience	NOUN
fnp-8974	265	121	,	,	PUNCT
fnp-8974	265	122	department	department	NOUN
fnp-8974	265	123	of	of	ADP
fnp-8974	265	124	neuroimmunology	neuroimmunology	PROPN
fnp-8974	265	125	,	,	PUNCT
fnp-8974	265	126	amsterdam	amsterdam	PROPN
fnp-8974	265	127	,	,	PUNCT
fnp-8974	265	128	netherlands	netherlands	PROPN
fnp-8974	265	129	4	4	NUM
fnp-8974	265	130	institute	institute	PROPN
fnp-8974	265	131	of	of	ADP
fnp-8974	265	132	translational	translational	ADJ
fnp-8974	265	133	neurology	neurology	NOUN
fnp-8974	265	134	,	,	PUNCT
fnp-8974	265	135	university	university	NOUN
fnp-8974	265	136	hospital	hospital	NOUN
fnp-8974	265	137	münster	münster	NOUN
fnp-8974	265	138	,	,	PUNCT
fnp-8974	265	139	münster	münster	PROPN
fnp-8974	265	140	,	,	PUNCT
fnp-8974	265	141	germany	germany	PROPN
fnp-8974	265	142	background	background	NOUN
fnp-8974	265	143	:	:	PUNCT
fnp-8974	265	144	myelin	myelin	ADJ
fnp-8974	265	145	-	-	PUNCT
fnp-8974	265	146	debris	debris	NOUN
fnp-8974	265	147	clearance	clearance	NOUN
fnp-8974	265	148	by	by	ADP
fnp-8974	265	149	myeloid	myeloid	ADJ
fnp-8974	265	150	cells	cell	NOUN
fnp-8974	265	151	in	in	ADP
fnp-8974	265	152	multiple	multiple	ADJ
fnp-8974	265	153	sclerosis	sclerosis	NOUN
fnp-8974	265	154	(	(	PUNCT
fnp-8974	265	155	ms)-lesions	ms)-lesion	NOUN
fnp-8974	265	156	is	be	AUX
fnp-8974	265	157	essential	essential	ADJ
fnp-8974	265	158	for	for	ADP
fnp-8974	265	159	remyelination	remyelination	NOUN
fnp-8974	265	160	,	,	PUNCT
fnp-8974	265	161	as	as	SCONJ
fnp-8974	265	162	myelin	myelin	NOUN
fnp-8974	265	163	-	-	PUNCT
fnp-8974	265	164	debris	debris	NOUN
fnp-8974	265	165	itself	itself	PRON
fnp-8974	265	166	can	can	AUX
fnp-8974	265	167	impede	impede	VERB
fnp-8974	265	168	this	this	DET
fnp-8974	265	169	process	process	NOUN
fnp-8974	265	170	.	.	PUNCT
fnp-8974	266	1	however	however	ADV
fnp-8974	266	2	,	,	PUNCT
fnp-8974	266	3	the	the	DET
fnp-8974	266	4	effects	effect	NOUN
fnp-8974	266	5	of	of	ADP
fnp-8974	266	6	myelin	myelin	NOUN
fnp-8974	266	7	-	-	PUNCT
fnp-8974	266	8	uptake	uptake	NOUN
fnp-8974	266	9	on	on	ADP
fnp-8974	266	10	macrophages	macrophage	NOUN
fnp-8974	266	11	remain	remain	VERB
fnp-8974	266	12	controversial	controversial	ADJ
fnp-8974	266	13	,	,	PUNCT
fnp-8974	266	14	with	with	ADP
fnp-8974	266	15	studies	study	NOUN
fnp-8974	266	16	reporting	report	VERB
fnp-8974	266	17	both	both	DET
fnp-8974	266	18	pro	pro	ADJ
fnp-8974	266	19	-	-	ADJ
fnp-8974	266	20	inflammatory	inflammatory	ADJ
fnp-8974	266	21	and	and	CCONJ
fnp-8974	266	22	disease	disease	NOUN
fnp-8974	266	23	-	-	PUNCT
fnp-8974	266	24	resolving	resolve	VERB
fnp-8974	266	25	phenotypes	phenotype	NOUN
fnp-8974	266	26	that	that	PRON
fnp-8974	266	27	could	could	AUX
fnp-8974	266	28	either	either	CCONJ
fnp-8974	266	29	hinder	hinder	VERB
fnp-8974	266	30	or	or	CCONJ
fnp-8974	266	31	promote	promote	VERB
fnp-8974	266	32	remyelination	remyelination	NOUN
fnp-8974	266	33	.	.	PUNCT
fnp-8974	267	1	notably	notably	ADV
fnp-8974	267	2	,	,	PUNCT
fnp-8974	267	3	human	human	NOUN
fnp-8974	267	4	-	-	PUNCT
fnp-8974	267	5	based	base	VERB
fnp-8974	267	6	data	datum	NOUN
fnp-8974	267	7	supporting	support	VERB
fnp-8974	267	8	the	the	DET
fnp-8974	267	9	latter	latter	ADJ
fnp-8974	267	10	hypothesis	hypothesis	NOUN
fnp-8974	267	11	and	and	CCONJ
fnp-8974	267	12	investigating	investigate	VERB
fnp-8974	267	13	subsequent	subsequent	ADJ
fnp-8974	267	14	effects	effect	NOUN
fnp-8974	267	15	on	on	ADP
fnp-8974	267	16	human	human	ADJ
fnp-8974	267	17	oligodendrocytes	oligodendrocyte	NOUN
fnp-8974	267	18	are	be	AUX
fnp-8974	267	19	lacking	lack	VERB
fnp-8974	267	20	.	.	PUNCT
fnp-8974	268	1	objective(s	objective(s	NOUN
fnp-8974	268	2	):	):	PUNCT
fnp-8974	268	3	here	here	ADV
fnp-8974	268	4	we	we	PRON
fnp-8974	268	5	investigate	investigate	VERB
fnp-8974	268	6	phenotypic	phenotypic	ADJ
fnp-8974	268	7	changes	change	NOUN
fnp-8974	268	8	in	in	ADP
fnp-8974	268	9	myeloid	myeloid	NOUN
fnp-8974	268	10	-	-	PUNCT
fnp-8974	268	11	cells	cell	NOUN
fnp-8974	268	12	due	due	ADJ
fnp-8974	268	13	to	to	ADP
fnp-8974	268	14	myelin	myelin	NOUN
fnp-8974	268	15	-	-	PUNCT
fnp-8974	268	16	uptake	uptake	NOUN
fnp-8974	268	17	at	at	ADP
fnp-8974	268	18	different	different	ADJ
fnp-8974	268	19	stages	stage	NOUN
fnp-8974	268	20	of	of	ADP
fnp-8974	268	21	myelin	myelin	NOUN
fnp-8974	268	22	-	-	PUNCT
fnp-8974	268	23	processing	processing	NOUN
fnp-8974	268	24	and	and	CCONJ
fnp-8974	268	25	their	their	PRON
fnp-8974	268	26	impact	impact	NOUN
fnp-8974	268	27	on	on	ADP
fnp-8974	268	28	human	human	ADJ
fnp-8974	268	29	oligodendrocyte	oligodendrocyte	NOUN
fnp-8974	268	30	-	-	PUNCT
fnp-8974	268	31	differentiation	differentiation	NOUN
fnp-8974	268	32	and	and	CCONJ
fnp-8974	268	33	(	(	PUNCT
fnp-8974	268	34	re)myelination	re)myelination	NOUN
fnp-8974	268	35	.	.	PUNCT
fnp-8974	269	1	method(s	method(	VERB
fnp-8974	269	2	):	):	PUNCT
fnp-8974	269	3	we	we	PRON
fnp-8974	269	4	analysed	analyse	VERB
fnp-8974	269	5	oligodendrocyte	oligodendrocyte	ADJ
fnp-8974	269	6	numbers	number	NOUN
fnp-8974	269	7	and	and	CCONJ
fnp-8974	269	8	remyelination	remyelination	NOUN
fnp-8974	269	9	in	in	ADP
fnp-8974	269	10	28	28	NUM
fnp-8974	269	11	lesions	lesion	NOUN
fnp-8974	269	12	from	from	ADP
fnp-8974	269	13	25	25	NUM
fnp-8974	269	14	ms	m	NOUN
fnp-8974	269	15	-	-	PUNCT
fnp-8974	269	16	patients	patient	NOUN
fnp-8974	269	17	,	,	PUNCT
fnp-8974	269	18	comparing	compare	VERB
fnp-8974	269	19	lesions	lesion	NOUN
fnp-8974	269	20	with	with	ADP
fnp-8974	269	21	and	and	CCONJ
fnp-8974	269	22	without	without	ADP
fnp-8974	269	23	lipid	lipid	NOUN
fnp-8974	269	24	-	-	PUNCT
fnp-8974	269	25	droplet	droplet	ADJ
fnp-8974	269	26	(	(	PUNCT
fnp-8974	269	27	ld)-forming	ld)-forme	VERB
fnp-8974	269	28	myeloid	myeloid	ADJ
fnp-8974	269	29	cells	cell	NOUN
fnp-8974	269	30	.	.	PUNCT
fnp-8974	270	1	myeloid	myeloid	NOUN
fnp-8974	270	2	-	-	PUNCT
fnp-8974	270	3	cells	cell	NOUN
fnp-8974	270	4	from	from	ADP
fnp-8974	270	5	controls	control	NOUN
fnp-8974	270	6	and	and	CCONJ
fnp-8974	270	7	ms	ms	NOUN
fnp-8974	270	8	-	-	PUNCT
fnp-8974	270	9	patients	patient	NOUN
fnp-8974	270	10	were	be	AUX
fnp-8974	270	11	exposed	expose	VERB
fnp-8974	270	12	to	to	ADP
fnp-8974	270	13	control	control	NOUN
fnp-8974	270	14	or	or	CCONJ
fnp-8974	270	15	ms	ms	NOUN
fnp-8974	270	16	-	-	PUNCT
fnp-8974	270	17	derived	derive	VERB
fnp-8974	270	18	myelin	myelin	NOUN
fnp-8974	270	19	for	for	ADP
fnp-8974	270	20	various	various	ADJ
fnp-8974	270	21	periods	period	NOUN
fnp-8974	270	22	.	.	PUNCT
fnp-8974	271	1	inflammatory	inflammatory	ADJ
fnp-8974	271	2	profiles	profile	NOUN
fnp-8974	271	3	were	be	AUX
fnp-8974	271	4	assessed	assess	VERB
fnp-8974	271	5	,	,	PUNCT
fnp-8974	271	6	and	and	CCONJ
fnp-8974	271	7	conditioned	condition	VERB
fnp-8974	271	8	media	medium	NOUN
fnp-8974	271	9	were	be	AUX
fnp-8974	271	10	applied	apply	VERB
fnp-8974	271	11	to	to	ADP
fnp-8974	271	12	ipsc	ipsc	NOUN
fnp-8974	271	13	-	-	PUNCT
fnp-8974	271	14	derived	derive	VERB
fnp-8974	271	15	oligodendrocytes	oligodendrocyte	NOUN
fnp-8974	271	16	(	(	PUNCT
fnp-8974	271	17	hiol	hiol	NOUN
fnp-8974	271	18	)	)	PUNCT
fnp-8974	271	19	to	to	PART
fnp-8974	271	20	evaluate	evaluate	VERB
fnp-8974	271	21	effects	effect	NOUN
fnp-8974	271	22	on	on	ADP
fnp-8974	271	23	differentiation	differentiation	NOUN
fnp-8974	271	24	.	.	PUNCT
fnp-8974	272	1	result(s	result(s	PROPN
fnp-8974	272	2	):	):	PUNCT
fnp-8974	272	3	no	no	DET
fnp-8974	272	4	correlation	correlation	NOUN
fnp-8974	272	5	was	be	AUX
fnp-8974	272	6	found	find	VERB
fnp-8974	272	7	between	between	ADP
fnp-8974	272	8	ld	ld	NOUN
fnp-8974	272	9	-	-	PUNCT
fnp-8974	272	10	forming	form	VERB
fnp-8974	272	11	macrophages	macrophage	NOUN
fnp-8974	272	12	and	and	CCONJ
fnp-8974	272	13	oligodendrocyte	oligodendrocyte	ADJ
fnp-8974	272	14	numbers	number	NOUN
fnp-8974	272	15	or	or	CCONJ
fnp-8974	272	16	remyelination	remyelination	NOUN
fnp-8974	272	17	in	in	ADP
fnp-8974	272	18	ms	ms	NOUN
fnp-8974	272	19	-	-	PUNCT
fnp-8974	272	20	lesions	lesion	NOUN
fnp-8974	272	21	.	.	PUNCT
fnp-8974	273	1	in	in	ADP
fnp-8974	273	2	vitro	vitro	X
fnp-8974	273	3	,	,	PUNCT
fnp-8974	273	4	myelin	myelin	NOUN
fnp-8974	273	5	-	-	PUNCT
fnp-8974	273	6	uptake	uptake	NOUN
fnp-8974	273	7	led	lead	VERB
fnp-8974	273	8	to	to	ADP
fnp-8974	273	9	a	a	DET
fnp-8974	273	10	proto	proto	NOUN
fnp-8974	273	11	anti	anti	ADJ
fnp-8974	273	12	-	-	ADJ
fnp-8974	273	13	inflammatory	inflammatory	ADJ
fnp-8974	273	14	shift	shift	NOUN
fnp-8974	273	15	in	in	ADP
fnp-8974	273	16	healthy	healthy	ADJ
fnp-8974	273	17	myeloid	myeloid	NOUN
fnp-8974	273	18	-	-	PUNCT
fnp-8974	273	19	cells	cell	NOUN
fnp-8974	273	20	,	,	PUNCT
fnp-8974	273	21	yet	yet	CCONJ
fnp-8974	273	22	hiol	hiol	NOUN
fnp-8974	273	23	differentiation	differentiation	NOUN
fnp-8974	273	24	was	be	AUX
fnp-8974	273	25	inhibited	inhibit	VERB
fnp-8974	273	26	at	at	ADP
fnp-8974	273	27	both	both	DET
fnp-8974	273	28	stages	stage	NOUN
fnp-8974	273	29	.	.	PUNCT
fnp-8974	274	1	unexpectedly	unexpectedly	ADV
fnp-8974	274	2	,	,	PUNCT
fnp-8974	274	3	in	in	ADP
fnp-8974	274	4	ms	ms	ADJ
fnp-8974	274	5	-	-	PUNCT
fnp-8974	274	6	macrophages	macrophage	NOUN
fnp-8974	274	7	,	,	PUNCT
fnp-8974	274	8	control	control	NOUN
fnp-8974	274	9	myelin	myelin	NOUN
fnp-8974	274	10	had	have	VERB
fnp-8974	274	11	minimal	minimal	ADJ
fnp-8974	274	12	effect	effect	NOUN
fnp-8974	274	13	,	,	PUNCT
fnp-8974	274	14	while	while	SCONJ
fnp-8974	274	15	ms	ms	ADJ
fnp-8974	274	16	-	-	PUNCT
fnp-8974	274	17	myelin	myelin	NOUN
fnp-8974	274	18	induced	induce	VERB
fnp-8974	274	19	polarization	polarization	NOUN
fnp-8974	274	20	and	and	CCONJ
fnp-8974	274	21	again	again	ADV
fnp-8974	274	22	inhibited	inhibit	VERB
fnp-8974	274	23	hiol	hiol	NOUN
fnp-8974	274	24	-	-	PUNCT
fnp-8974	274	25	differentiation	differentiation	NOUN
fnp-8974	274	26	.	.	PUNCT
fnp-8974	275	1	conclusion(s	conclusion(s	NOUN
fnp-8974	275	2	):	):	PUNCT
fnp-8974	275	3	although	although	SCONJ
fnp-8974	275	4	myelin	myelin	NOUN
fnp-8974	275	5	-	-	PUNCT
fnp-8974	275	6	uptake	uptake	NOUN
fnp-8974	275	7	promotes	promote	VERB
fnp-8974	275	8	an	an	DET
fnp-8974	275	9	anti	anti	ADJ
fnp-8974	275	10	-	-	ADJ
fnp-8974	275	11	inflammatory	inflammatory	ADJ
fnp-8974	275	12	shift	shift	NOUN
fnp-8974	275	13	in	in	ADP
fnp-8974	275	14	myeloid	myeloid	NOUN
fnp-8974	275	15	-	-	PUNCT
fnp-8974	275	16	cells	cell	NOUN
fnp-8974	275	17	,	,	PUNCT
fnp-8974	275	18	this	this	PRON
fnp-8974	275	19	did	do	AUX
fnp-8974	275	20	not	not	PART
fnp-8974	275	21	support	support	VERB
fnp-8974	275	22	oligodendrocyte	oligodendrocyte	ADJ
fnp-8974	275	23	-	-	PUNCT
fnp-8974	275	24	differentiation	differentiation	NOUN
fnp-8974	275	25	.	.	PUNCT
fnp-8974	276	1	furthermore	furthermore	ADV
fnp-8974	276	2	,	,	PUNCT
fnp-8974	276	3	ld	ld	NOUN
fnp-8974	276	4	-	-	PUNCT
fnp-8974	276	5	formation	formation	NOUN
fnp-8974	276	6	did	do	AUX
fnp-8974	276	7	not	not	PART
fnp-8974	276	8	associate	associate	VERB
fnp-8974	276	9	with	with	ADP
fnp-8974	276	10	remyelination	remyelination	NOUN
fnp-8974	276	11	in	in	ADP
fnp-8974	276	12	ms	ms	NOUN
fnp-8974	276	13	-	-	PUNCT
fnp-8974	276	14	lesions	lesion	NOUN
fnp-8974	276	15	.	.	PUNCT
fnp-8974	277	1	concluding	concluding	NOUN
fnp-8974	277	2	:	:	PUNCT
fnp-8974	277	3	contrary	contrary	ADJ
fnp-8974	277	4	to	to	ADP
fnp-8974	277	5	published	publish	VERB
fnp-8974	277	6	animal	animal	NOUN
fnp-8974	277	7	studies	study	NOUN
fnp-8974	277	8	,	,	PUNCT
fnp-8974	277	9	our	our	PRON
fnp-8974	277	10	findings	finding	NOUN
fnp-8974	277	11	,	,	PUNCT
fnp-8974	277	12	using	use	VERB
fnp-8974	277	13	human	human	ADJ
fnp-8974	277	14	oligodendrocyte	oligodendrocyte	ADJ
fnp-8974	277	15	lineage	lineage	NOUN
fnp-8974	277	16	cells	cell	NOUN
fnp-8974	277	17	,	,	PUNCT
fnp-8974	277	18	show	show	VERB
fnp-8974	277	19	no	no	DET
fnp-8974	277	20	evidence	evidence	NOUN
fnp-8974	277	21	for	for	ADP
fnp-8974	277	22	a	a	DET
fnp-8974	277	23	role	role	NOUN
fnp-8974	277	24	of	of	ADP
fnp-8974	277	25	ld	ld	NOUN
fnp-8974	277	26	-	-	PUNCT
fnp-8974	277	27	formation	formation	NOUN
fnp-8974	277	28	in	in	ADP
fnp-8974	277	29	macrophages	macrophage	NOUN
fnp-8974	277	30	on	on	ADP
fnp-8974	277	31	remyelination	remyelination	NOUN
fnp-8974	277	32	failure	failure	NOUN
fnp-8974	277	33	and	and	CCONJ
fnp-8974	277	34	no	no	DET
fnp-8974	277	35	evidence	evidence	NOUN
fnp-8974	277	36	that	that	SCONJ
fnp-8974	277	37	an	an	DET
fnp-8974	277	38	anti	anti	ADJ
fnp-8974	277	39	-	-	ADJ
fnp-8974	277	40	inflammatory	inflammatory	ADJ
fnp-8974	277	41	phenotype	phenotype	NOUN
fnp-8974	277	42	promotes	promote	VERB
fnp-8974	277	43	oligodendrocyte	oligodendrocyte	ADJ
fnp-8974	277	44	-	-	PUNCT
fnp-8974	277	45	differentiation	differentiation	NOUN
fnp-8974	277	46	.	.	PUNCT
fnp-8974	278	1	p21	p21	PROPN
fnp-8974	278	2	free	free	ADJ
fnp-8974	278	3	neuropathol	neuropathol	NOUN
fnp-8974	278	4	6:17:34	6:17:34	NUM
fnp-8974	278	5	remyelination	remyelination	NOUN
fnp-8974	278	6	in	in	ADP
fnp-8974	278	7	multiple	multiple	ADJ
fnp-8974	278	8	sclerosis	sclerosis	NOUN
fnp-8974	278	9	depends	depend	VERB
fnp-8974	278	10	on	on	ADP
fnp-8974	278	11	the	the	DET
fnp-8974	278	12	mechanism	mechanism	NOUN
fnp-8974	278	13	of	of	ADP
fnp-8974	278	14	lesion	lesion	NOUN
fnp-8974	278	15	development	development	PROPN
fnp-8974	278	16	lidia	lidia	PROPN
fnp-8974	278	17	stork1	stork1	PROPN
fnp-8974	278	18	,	,	PUNCT
fnp-8974	278	19	theresa	theresa	PROPN
fnp-8974	278	20	klossok1	klossok1	PROPN
fnp-8974	278	21	,	,	PUNCT
fnp-8974	278	22	imke	imke	PROPN
fnp-8974	278	23	metz1	metz1	PROPN
fnp-8974	278	24	1	1	NUM
fnp-8974	278	25	university	university	NOUN
fnp-8974	278	26	medical	medical	ADJ
fnp-8974	278	27	center	center	NOUN
fnp-8974	278	28	göttingen	göttingen	NOUN
fnp-8974	278	29	,	,	PUNCT
fnp-8974	278	30	institute	institute	NOUN
fnp-8974	278	31	of	of	ADP
fnp-8974	278	32	neuropathology	neuropathology	NOUN
fnp-8974	278	33	,	,	PUNCT
fnp-8974	278	34	göttingen	göttingen	PROPN
fnp-8974	278	35	,	,	PUNCT
fnp-8974	278	36	germany	germany	PROPN
fnp-8974	278	37	immunopathological	immunopathological	ADJ
fnp-8974	278	38	patterns	pattern	NOUN
fnp-8974	278	39	are	be	AUX
fnp-8974	278	40	histological	histological	ADJ
fnp-8974	278	41	signatures	signature	NOUN
fnp-8974	278	42	reflecting	reflect	VERB
fnp-8974	278	43	the	the	DET
fnp-8974	278	44	heterogeneity	heterogeneity	NOUN
fnp-8974	278	45	of	of	ADP
fnp-8974	278	46	multiple	multiple	ADJ
fnp-8974	278	47	sclerosis	sclerosis	NOUN
fnp-8974	278	48	(	(	PUNCT
fnp-8974	278	49	ms	ms	NOUN
fnp-8974	278	50	)	)	PUNCT
fnp-8974	278	51	,	,	PUNCT
fnp-8974	278	52	encompassing	encompass	VERB
fnp-8974	278	53	clinical	clinical	ADJ
fnp-8974	278	54	symptoms	symptom	NOUN
fnp-8974	278	55	and	and	CCONJ
fnp-8974	278	56	treatment	treatment	NOUN
fnp-8974	278	57	response	response	NOUN
fnp-8974	278	58	.	.	PUNCT
fnp-8974	279	1	patterns	pattern	NOUN
fnp-8974	279	2	suggest	suggest	VERB
fnp-8974	279	3	different	different	ADJ
fnp-8974	279	4	mechanisms	mechanism	NOUN
fnp-8974	279	5	of	of	ADP
fnp-8974	279	6	lesion	lesion	NOUN
fnp-8974	279	7	development	development	NOUN
fnp-8974	279	8	:	:	PUNCT
fnp-8974	279	9	pattern	pattern	NOUN
fnp-8974	279	10	i	i	PRON
fnp-8974	279	11	and	and	CCONJ
fnp-8974	279	12	ii	ii	PROPN
fnp-8974	279	13	with	with	ADP
fnp-8974	279	14	immune	immune	NOUN
fnp-8974	279	15	-	-	PUNCT
fnp-8974	279	16	mediated	mediate	VERB
fnp-8974	279	17	demyelination	demyelination	NOUN
fnp-8974	279	18	,	,	PUNCT
fnp-8974	279	19	and	and	CCONJ
fnp-8974	279	20	pattern	pattern	NOUN
fnp-8974	279	21	iii	iii	NOUN
fnp-8974	279	22	reflecting	reflect	VERB
fnp-8974	279	23	primary	primary	ADJ
fnp-8974	279	24	oligodendrocyte	oligodendrocyte	ADJ
fnp-8974	279	25	damage	damage	NOUN
fnp-8974	279	26	.	.	PUNCT
fnp-8974	280	1	we	we	PRON
fnp-8974	280	2	hypothesized	hypothesize	VERB
fnp-8974	280	3	that	that	SCONJ
fnp-8974	280	4	these	these	DET
fnp-8974	280	5	mechanisms	mechanism	NOUN
fnp-8974	280	6	also	also	ADV
fnp-8974	280	7	influence	influence	VERB
fnp-8974	280	8	remyelination	remyelination	NOUN
fnp-8974	280	9	in	in	ADP
fnp-8974	280	10	ms	ms	PROPN
fnp-8974	280	11	.	.	PROPN
fnp-8974	280	12	using	use	VERB
fnp-8974	280	13	the	the	DET
fnp-8974	280	14	bcas1	bcas1	NOUN
fnp-8974	280	15	marker	marker	NOUN
fnp-8974	280	16	for	for	ADP
fnp-8974	280	17	remyelinating	remyelinate	VERB
fnp-8974	280	18	oligodendrocytes	oligodendrocyte	NOUN
fnp-8974	280	19	,	,	PUNCT
fnp-8974	280	20	we	we	PRON
fnp-8974	280	21	analyzed	analyze	VERB
fnp-8974	280	22	the	the	DET
fnp-8974	280	23	number	number	NOUN
fnp-8974	280	24	and	and	CCONJ
fnp-8974	280	25	morphological	morphological	ADJ
fnp-8974	280	26	characteristics	characteristic	NOUN
fnp-8974	280	27	of	of	ADP
fnp-8974	280	28	bcas1	bcas1	NOUN
fnp-8974	280	29	+	+	SYM
fnp-8974	280	30	cells	cell	NOUN
fnp-8974	280	31	across	across	ADP
fnp-8974	280	32	the	the	DET
fnp-8974	280	33	three	three	NUM
fnp-8974	280	34	patterns	pattern	NOUN
fnp-8974	280	35	.	.	PUNCT
fnp-8974	281	1	additionally	additionally	ADV
fnp-8974	281	2	,	,	PUNCT
fnp-8974	281	3	we	we	PRON
fnp-8974	281	4	analyzed	analyze	VERB
fnp-8974	281	5	oligodendrocyte	oligodendrocyte	ADJ
fnp-8974	281	6	precursor	precursor	NOUN
fnp-8974	281	7	cells	cell	NOUN
fnp-8974	281	8	(	(	PUNCT
fnp-8974	281	9	strong	strong	ADJ
fnp-8974	281	10	olig2	olig2	NOUN
fnp-8974	281	11	+	+	NOUN
fnp-8974	281	12	)	)	PUNCT
fnp-8974	281	13	and	and	CCONJ
fnp-8974	281	14	mature	mature	VERB
fnp-8974	281	15	nogoa+	nogoa+	NOUN
fnp-8974	281	16	cells	cell	NOUN
fnp-8974	281	17	.	.	PUNCT
fnp-8974	282	1	for	for	ADP
fnp-8974	282	2	oligodendrocyte	oligodendrocyte	ADJ
fnp-8974	282	3	precursor	precursor	NOUN
fnp-8974	282	4	cells	cell	NOUN
fnp-8974	282	5	,	,	PUNCT
fnp-8974	282	6	no	no	DET
fnp-8974	282	7	significant	significant	ADJ
fnp-8974	282	8	difference	difference	NOUN
fnp-8974	282	9	was	be	AUX
fnp-8974	282	10	observed	observe	VERB
fnp-8974	282	11	between	between	ADP
fnp-8974	282	12	patterns	pattern	NOUN
fnp-8974	282	13	(	(	PUNCT
fnp-8974	282	14	p	p	X
fnp-8974	282	15	 	 	SPACE
fnp-8974	282	16	=	=	NOUN
fnp-8974	282	17	 	 	SPACE
fnp-8974	282	18	0.4	0.4	NUM
fnp-8974	282	19	)	)	PUNCT
fnp-8974	282	20	,	,	PUNCT
fnp-8974	282	21	but	but	CCONJ
fnp-8974	282	22	mature	mature	VERB
fnp-8974	282	23	nogoa+	nogoa+	PRON
fnp-8974	282	24	oligodendrocytes	oligodendrocyte	NOUN
fnp-8974	282	25	were	be	AUX
fnp-8974	282	26	slightly	slightly	ADV
fnp-8974	282	27	higher	high	ADJ
fnp-8974	282	28	in	in	ADP
fnp-8974	282	29	pattern	pattern	NOUN
fnp-8974	282	30	iii	iii	NOUN
fnp-8974	282	31	.	.	PUNCT
fnp-8974	283	1	the	the	DET
fnp-8974	283	2	number	number	NOUN
fnp-8974	283	3	of	of	ADP
fnp-8974	283	4	bcas1	bcas1	NOUN
fnp-8974	283	5	+	+	SYM
fnp-8974	283	6	cells	cell	NOUN
fnp-8974	283	7	exhibited	exhibit	VERB
fnp-8974	283	8	considerable	considerable	ADJ
fnp-8974	283	9	variability	variability	NOUN
fnp-8974	283	10	among	among	ADP
fnp-8974	283	11	patients	patient	NOUN
fnp-8974	283	12	,	,	PUNCT
fnp-8974	283	13	with	with	ADP
fnp-8974	283	14	some	some	PRON
fnp-8974	283	15	showing	show	VERB
fnp-8974	283	16	low	low	ADJ
fnp-8974	283	17	(	(	PUNCT
fnp-8974	283	18	median	median	NOUN
fnp-8974	283	19	:	:	PUNCT
fnp-8974	283	20	4.5	4.5	NUM
fnp-8974	283	21	 	 	SPACE
fnp-8974	283	22	cells	cell	NOUN
fnp-8974	283	23	/	/	SYM
fnp-8974	283	24	mm²	mm²	PROPN
fnp-8974	283	25	)	)	PUNCT
fnp-8974	283	26	,	,	PUNCT
fnp-8974	283	27	moderate	moderate	ADJ
fnp-8974	283	28	(	(	PUNCT
fnp-8974	283	29	median	median	NOUN
fnp-8974	283	30	:	:	PUNCT
fnp-8974	283	31	15.5	15.5	NUM
fnp-8974	283	32	 	 	SPACE
fnp-8974	283	33	cells	cell	NOUN
fnp-8974	283	34	/	/	SYM
fnp-8974	283	35	mm²	mm²	PROPN
fnp-8974	283	36	)	)	PUNCT
fnp-8974	283	37	,	,	PUNCT
fnp-8974	283	38	or	or	CCONJ
fnp-8974	283	39	high	high	ADJ
fnp-8974	283	40	(	(	PUNCT
fnp-8974	283	41	median	median	NOUN
fnp-8974	283	42	:	:	PUNCT
fnp-8974	283	43	44.1	44.1	NUM
fnp-8974	283	44	 	 	SPACE
fnp-8974	283	45	cells	cell	NOUN
fnp-8974	283	46	/	/	SYM
fnp-8974	283	47	mm²	mm²	NOUN
fnp-8974	283	48	)	)	PUNCT
fnp-8974	283	49	numbers	number	NOUN
fnp-8974	283	50	.	.	PUNCT
fnp-8974	284	1	no	no	DET
fnp-8974	284	2	significant	significant	ADJ
fnp-8974	284	3	differences	difference	NOUN
fnp-8974	284	4	were	be	AUX
fnp-8974	284	5	found	find	VERB
fnp-8974	284	6	between	between	ADP
fnp-8974	284	7	the	the	DET
fnp-8974	284	8	immunopathological	immunopathological	ADJ
fnp-8974	284	9	patterns	pattern	NOUN
fnp-8974	284	10	for	for	ADP
fnp-8974	284	11	bcas1	bcas1	NOUN
fnp-8974	284	12	+	+	SYM
fnp-8974	284	13	cells	cell	NOUN
fnp-8974	284	14	(	(	PUNCT
fnp-8974	284	15	p	p	X
fnp-8974	284	16	 	 	SPACE
fnp-8974	284	17	=	=	NOUN
fnp-8974	284	18	 	 	SPACE
fnp-8974	284	19	0.9	0.9	NUM
fnp-8974	284	20	)	)	PUNCT
fnp-8974	284	21	.	.	PUNCT
fnp-8974	285	1	to	to	PART
fnp-8974	285	2	assess	assess	VERB
fnp-8974	285	3	active	active	ADJ
fnp-8974	285	4	myelination	myelination	NOUN
fnp-8974	285	5	,	,	PUNCT
fnp-8974	285	6	we	we	PRON
fnp-8974	285	7	used	use	VERB
fnp-8974	285	8	double	double	ADJ
fnp-8974	285	9	immunofluorescence	immunofluorescence	NOUN
fnp-8974	285	10	with	with	ADP
fnp-8974	285	11	myelin	myelin	NOUN
fnp-8974	285	12	-	-	PUNCT
fnp-8974	285	13	associated	associate	VERB
fnp-8974	285	14	glycoprotein	glycoprotein	NOUN
fnp-8974	285	15	(	(	PUNCT
fnp-8974	285	16	mag	mag	ADJ
fnp-8974	285	17	)	)	PUNCT
fnp-8974	285	18	.	.	PUNCT
fnp-8974	286	1	the	the	DET
fnp-8974	286	2	ratio	ratio	NOUN
fnp-8974	286	3	of	of	ADP
fnp-8974	286	4	bcas1+mag+	bcas1+mag+	NOUN
fnp-8974	286	5	to	to	ADP
fnp-8974	286	6	all	all	DET
fnp-8974	286	7	bcas1	bcas1	NOUN
fnp-8974	286	8	+	+	SYM
fnp-8974	286	9	cells	cell	NOUN
fnp-8974	286	10	was	be	AUX
fnp-8974	286	11	similar	similar	ADJ
fnp-8974	286	12	across	across	ADP
fnp-8974	286	13	patterns	pattern	NOUN
fnp-8974	286	14	,	,	PUNCT
fnp-8974	286	15	but	but	CCONJ
fnp-8974	286	16	pattern	pattern	NOUN
fnp-8974	286	17	iii	iii	NOUN
fnp-8974	286	18	was	be	AUX
fnp-8974	286	19	characterized	characterize	VERB
fnp-8974	286	20	by	by	ADP
fnp-8974	286	21	a	a	DET
fnp-8974	286	22	significantly	significantly	ADV
fnp-8974	286	23	higher	high	ADJ
fnp-8974	286	24	number	number	NOUN
fnp-8974	286	25	of	of	ADP
fnp-8974	286	26	ramified	ramified	ADJ
fnp-8974	286	27	bcas1+mag+	bcas1+mag+	ADJ
fnp-8974	286	28	oligodendrocytes	oligodendrocyte	NOUN
fnp-8974	286	29	(	(	PUNCT
fnp-8974	286	30	median	median	ADJ
fnp-8974	286	31	:	:	PUNCT
fnp-8974	286	32	pattern	pattern	NOUN
fnp-8974	286	33	i	i	PRON
fnp-8974	286	34	:	:	PUNCT
fnp-8974	286	35	0.2	0.2	NUM
fnp-8974	286	36	,	,	PUNCT
fnp-8974	286	37	pattern	pattern	NOUN
fnp-8974	286	38	ii	ii	NOUN
fnp-8974	286	39	:	:	PUNCT
fnp-8974	286	40	0.2	0.2	NUM
fnp-8974	286	41	,	,	PUNCT
fnp-8974	286	42	pattern	pattern	NOUN
fnp-8974	286	43	iii	iii	NOUN
fnp-8974	286	44	:	:	PUNCT
fnp-8974	286	45	0.5	0.5	NUM
fnp-8974	286	46	cells	cell	NOUN
fnp-8974	286	47	;	;	PUNCT
fnp-8974	286	48	p	p	X
fnp-8974	286	49	 	 	SPACE
fnp-8974	286	50	=	=	NOUN
fnp-8974	286	51	 	 	SPACE
fnp-8974	286	52	0.04	0.04	NUM
fnp-8974	286	53	)	)	PUNCT
fnp-8974	286	54	.	.	PUNCT
fnp-8974	287	1	in	in	ADP
fnp-8974	287	2	conclusion	conclusion	NOUN
fnp-8974	287	3	,	,	PUNCT
fnp-8974	287	4	these	these	DET
fnp-8974	287	5	findings	finding	NOUN
fnp-8974	287	6	indicate	indicate	VERB
fnp-8974	287	7	that	that	SCONJ
fnp-8974	287	8	lesions	lesion	NOUN
fnp-8974	287	9	of	of	ADP
fnp-8974	287	10	pattern	pattern	NOUN
fnp-8974	287	11	iii	iii	NOUN
fnp-8974	287	12	,	,	PUNCT
fnp-8974	287	13	despite	despite	SCONJ
fnp-8974	287	14	being	be	AUX
fnp-8974	287	15	characterized	characterize	VERB
fnp-8974	287	16	by	by	ADP
fnp-8974	287	17	primary	primary	ADJ
fnp-8974	287	18	oligodendrocyte	oligodendrocyte	ADJ
fnp-8974	287	19	dystrophy	dystrophy	NOUN
fnp-8974	287	20	,	,	PUNCT
fnp-8974	287	21	paradoxically	paradoxically	ADV
fnp-8974	287	22	demonstrate	demonstrate	VERB
fnp-8974	287	23	a	a	DET
fnp-8974	287	24	significantly	significantly	ADV
fnp-8974	287	25	higher	high	ADJ
fnp-8974	287	26	number	number	NOUN
fnp-8974	287	27	of	of	ADP
fnp-8974	287	28	mature	mature	ADJ
fnp-8974	287	29	oligodendrocytes	oligodendrocyte	NOUN
fnp-8974	287	30	and	and	CCONJ
fnp-8974	287	31	ramified	ramify	VERB
fnp-8974	287	32	,	,	PUNCT
fnp-8974	287	33	active	active	ADJ
fnp-8974	287	34	myelinating	myelinate	VERB
fnp-8974	287	35	bcas1	bcas1	NOUN
fnp-8974	287	36	+	+	SYM
fnp-8974	287	37	cells	cell	NOUN
fnp-8974	287	38	in	in	ADP
fnp-8974	287	39	areas	area	NOUN
fnp-8974	287	40	of	of	ADP
fnp-8974	287	41	tissue	tissue	NOUN
fnp-8974	287	42	response	response	NOUN
fnp-8974	287	43	,	,	PUNCT
fnp-8974	287	44	potentially	potentially	ADV
fnp-8974	287	45	reflecting	reflect	VERB
fnp-8974	287	46	an	an	DET
fnp-8974	287	47	enhanced	enhanced	ADJ
fnp-8974	287	48	reactive	reactive	ADJ
fnp-8974	287	49	regenerative	regenerative	ADJ
fnp-8974	287	50	capacity	capacity	NOUN
fnp-8974	287	51	and	and	CCONJ
fnp-8974	287	52	superior	superior	ADJ
fnp-8974	287	53	remyelination	remyelination	NOUN
fnp-8974	287	54	potential	potential	NOUN
fnp-8974	287	55	compared	compare	VERB
fnp-8974	287	56	to	to	ADP
fnp-8974	287	57	other	other	ADJ
fnp-8974	287	58	lesional	lesional	ADJ
fnp-8974	287	59	patterns	pattern	NOUN
fnp-8974	287	60	.	.	PUNCT
fnp-8974	288	1	p22	p22	VERB
fnp-8974	288	2	free	free	ADJ
fnp-8974	288	3	neuropathol	neuropathol	NOUN
fnp-8974	288	4	6:17:35	6:17:35	NUM
fnp-8974	288	5	il-12	il-12	NOUN
fnp-8974	288	6	drives	drive	NOUN
fnp-8974	288	7	neuroinflammation	neuroinflammation	NOUN
fnp-8974	288	8	-	-	PUNCT
fnp-8974	288	9	linked	link	VERB
fnp-8974	288	10	lipid	lipid	NOUN
fnp-8974	288	11	dysregulation	dysregulation	NOUN
fnp-8974	288	12	in	in	ADP
fnp-8974	288	13	a	a	DET
fnp-8974	288	14	mouse	mouse	NOUN
fnp-8974	288	15	model	model	NOUN
fnp-8974	288	16	of	of	ADP
fnp-8974	288	17	alzheimer	alzheimer	PROPN
fnp-8974	288	18	’s	’s	PART
fnp-8974	288	19	disease	disease	NOUN
fnp-8974	288	20	maria	maria	PROPN
fnp-8974	288	21	geesdorf1	geesdorf1	PROPN
fnp-8974	288	22	,	,	PUNCT
fnp-8974	288	23	marina	marina	PROPN
fnp-8974	288	24	jendrach1	jendrach1	PROPN
fnp-8974	288	25	,	,	PUNCT
fnp-8974	288	26	andreas	andreas	PROPN
fnp-8974	288	27	hülsmeier2	hülsmeier2	PROPN
fnp-8974	288	28	,	,	PUNCT
fnp-8974	288	29	thorsten	thorsten	PROPN
fnp-8974	288	30	hornemann2	hornemann2	PROPN
fnp-8974	288	31	,	,	PUNCT
fnp-8974	288	32	frank	frank	PROPN
fnp-8974	288	33	heppner1	heppner1	PROPN
fnp-8974	288	34	1	1	NUM
fnp-8974	288	35	charité	charité	PROPN
fnp-8974	288	36	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	288	37	berlin	berlin	PROPN
fnp-8974	288	38	,	,	PUNCT
fnp-8974	288	39	institut	institut	PROPN
fnp-8974	288	40	für	für	PROPN
fnp-8974	288	41	neuropathologie	neuropathologie	PROPN
fnp-8974	288	42	,	,	PUNCT
fnp-8974	288	43	berlin	berlin	PROPN
fnp-8974	288	44	,	,	PUNCT
fnp-8974	288	45	germany	germany	PROPN
fnp-8974	288	46	2	2	NUM
fnp-8974	288	47	universitätsspital	universitätsspital	PROPN
fnp-8974	288	48	zürich	zürich	PROPN
fnp-8974	288	49	,	,	PUNCT
fnp-8974	288	50	institut	institut	PROPN
fnp-8974	288	51	für	für	PROPN
fnp-8974	288	52	klinische	klinische	PROPN
fnp-8974	288	53	chemie	chemie	PROPN
fnp-8974	288	54	,	,	PUNCT
fnp-8974	288	55	zürich	zürich	PROPN
fnp-8974	288	56	,	,	PUNCT
fnp-8974	288	57	switzerland	switzerland	PROPN
fnp-8974	288	58	background	background	NOUN
fnp-8974	288	59	:	:	PUNCT
fnp-8974	288	60	neuroinflammation	neuroinflammation	NOUN
fnp-8974	288	61	is	be	AUX
fnp-8974	288	62	central	central	ADJ
fnp-8974	288	63	to	to	ADP
fnp-8974	288	64	alzheimer	alzheimer	PROPN
fnp-8974	288	65	’s	’s	PART
fnp-8974	288	66	disease	disease	NOUN
fnp-8974	288	67	(	(	PUNCT
fnp-8974	288	68	ad	ad	NOUN
fnp-8974	288	69	)	)	PUNCT
fnp-8974	288	70	pathology	pathology	NOUN
fnp-8974	288	71	.	.	PUNCT
fnp-8974	289	1	microglia	microglia	ADJ
fnp-8974	289	2	-	-	PUNCT
fnp-8974	289	3	derived	derive	VERB
fnp-8974	289	4	interleukin	interleukin	NOUN
fnp-8974	289	5	(	(	PUNCT
fnp-8974	289	6	il)-12	il)-12	PROPN
fnp-8974	289	7	promotes	promote	VERB
fnp-8974	289	8	inflammation	inflammation	NOUN
fnp-8974	289	9	and	and	CCONJ
fnp-8974	289	10	disease	disease	NOUN
fnp-8974	289	11	progression	progression	NOUN
fnp-8974	289	12	in	in	ADP
fnp-8974	289	13	ad	ad	NOUN
fnp-8974	289	14	patients	patient	NOUN
fnp-8974	289	15	and	and	CCONJ
fnp-8974	289	16	appps1	appps1	NOUN
fnp-8974	289	17	mice	mouse	NOUN
fnp-8974	289	18	,	,	PUNCT
fnp-8974	289	19	which	which	PRON
fnp-8974	289	20	recapitulate	recapitulate	VERB
fnp-8974	289	21	the	the	DET
fnp-8974	289	22	first	first	ADJ
fnp-8974	289	23	stages	stage	NOUN
fnp-8974	289	24	of	of	ADP
fnp-8974	289	25	ad	ad	NOUN
fnp-8974	289	26	,	,	PUNCT
fnp-8974	289	27	with	with	ADP
fnp-8974	289	28	amyloid	amyloid	NOUN
fnp-8974	289	29	beta	beta	NOUN
fnp-8974	289	30	(	(	PUNCT
fnp-8974	289	31	a	a	DET
fnp-8974	289	32	β	β	NOUN
fnp-8974	289	33	)	)	PUNCT
fnp-8974	289	34	accumulation	accumulation	NOUN
fnp-8974	289	35	,	,	PUNCT
fnp-8974	289	36	neuroinflammation	neuroinflammation	NOUN
fnp-8974	289	37	,	,	PUNCT
fnp-8974	289	38	and	and	CCONJ
fnp-8974	289	39	myelin	myelin	ADJ
fnp-8974	289	40	disruption	disruption	NOUN
fnp-8974	289	41	.	.	PUNCT
fnp-8974	290	1	objective(s	objective(s	NOUN
fnp-8974	290	2	):	):	PUNCT
fnp-8974	290	3	lipid	lipid	ADJ
fnp-8974	290	4	metabolism	metabolism	NOUN
fnp-8974	290	5	seems	seem	VERB
fnp-8974	290	6	to	to	PART
fnp-8974	290	7	be	be	AUX
fnp-8974	290	8	altered	alter	VERB
fnp-8974	290	9	in	in	ADP
fnp-8974	290	10	ad	ad	NOUN
fnp-8974	290	11	,	,	PUNCT
fnp-8974	290	12	but	but	CCONJ
fnp-8974	290	13	the	the	DET
fnp-8974	290	14	interplay	interplay	NOUN
fnp-8974	290	15	with	with	ADP
fnp-8974	290	16	neuroinflammation	neuroinflammation	NOUN
fnp-8974	290	17	is	be	AUX
fnp-8974	290	18	yet	yet	ADV
fnp-8974	290	19	unclear	unclear	ADJ
fnp-8974	290	20	.	.	PUNCT
fnp-8974	291	1	therefore	therefore	ADV
fnp-8974	291	2	,	,	PUNCT
fnp-8974	291	3	we	we	PRON
fnp-8974	291	4	aimed	aim	VERB
fnp-8974	291	5	to	to	PART
fnp-8974	291	6	characterize	characterize	VERB
fnp-8974	291	7	lipidomic	lipidomic	ADJ
fnp-8974	291	8	alterations	alteration	NOUN
fnp-8974	291	9	and	and	CCONJ
fnp-8974	291	10	metabolic	metabolic	NOUN
fnp-8974	291	11	changes	change	NOUN
fnp-8974	291	12	in	in	ADP
fnp-8974	291	13	key	key	ADJ
fnp-8974	291	14	brain	brain	NOUN
fnp-8974	291	15	cells	cell	NOUN
fnp-8974	291	16	during	during	ADP
fnp-8974	291	17	ad	ad	NOUN
fnp-8974	291	18	progression	progression	NOUN
fnp-8974	291	19	in	in	ADP
fnp-8974	291	20	the	the	DET
fnp-8974	291	21	appps1	appps1	PROPN
fnp-8974	291	22	mouse	mouse	PROPN
fnp-8974	291	23	model	model	NOUN
fnp-8974	291	24	and	and	CCONJ
fnp-8974	291	25	clarify	clarify	VERB
fnp-8974	291	26	il-12	il-12	NOUN
fnp-8974	291	27	’s	’s	PART
fnp-8974	291	28	role	role	NOUN
fnp-8974	291	29	in	in	ADP
fnp-8974	291	30	these	these	DET
fnp-8974	291	31	processes	process	NOUN
fnp-8974	291	32	.	.	PUNCT
fnp-8974	292	1	question(s	question(s	NOUN
fnp-8974	292	2	):	):	PUNCT
fnp-8974	292	3	1	1	X
fnp-8974	292	4	.	.	X
fnp-8974	293	1	how	how	SCONJ
fnp-8974	293	2	is	be	AUX
fnp-8974	293	3	the	the	DET
fnp-8974	293	4	lipidomic	lipidomic	ADJ
fnp-8974	293	5	profile	profile	NOUN
fnp-8974	293	6	,	,	PUNCT
fnp-8974	293	7	especially	especially	ADV
fnp-8974	293	8	sphingolipids	sphingolipid	NOUN
fnp-8974	293	9	and	and	CCONJ
fnp-8974	293	10	myelin	myelin	NOUN
fnp-8974	293	11	-	-	PUNCT
fnp-8974	293	12	related	relate	VERB
fnp-8974	293	13	lipids	lipid	NOUN
fnp-8974	293	14	,	,	PUNCT
fnp-8974	293	15	affected	affect	VERB
fnp-8974	293	16	at	at	ADP
fnp-8974	293	17	different	different	ADJ
fnp-8974	293	18	disease	disease	NOUN
fnp-8974	293	19	stages	stage	NOUN
fnp-8974	293	20	?	?	PUNCT
fnp-8974	294	1	2	2	X
fnp-8974	294	2	.	.	X
fnp-8974	294	3	how	how	SCONJ
fnp-8974	294	4	do	do	AUX
fnp-8974	294	5	a	a	DET
fnp-8974	294	6	β	β	X
fnp-8974	294	7	and	and	CCONJ
fnp-8974	294	8	myelin	myelin	NOUN
fnp-8974	294	9	pathology	pathology	NOUN
fnp-8974	294	10	impact	impact	NOUN
fnp-8974	294	11	metabolic	metabolic	NOUN
fnp-8974	294	12	function	function	NOUN
fnp-8974	294	13	in	in	ADP
fnp-8974	294	14	diverse	diverse	ADJ
fnp-8974	294	15	cell	cell	NOUN
fnp-8974	294	16	types	type	NOUN
fnp-8974	294	17	?	?	PUNCT
fnp-8974	295	1	3	3	X
fnp-8974	295	2	.	.	X
fnp-8974	295	3	does	do	AUX
fnp-8974	295	4	il-12	il-12	NOUN
fnp-8974	295	5	play	play	VERB
fnp-8974	295	6	a	a	DET
fnp-8974	295	7	role	role	NOUN
fnp-8974	295	8	in	in	ADP
fnp-8974	295	9	modulating	modulate	VERB
fnp-8974	295	10	these	these	DET
fnp-8974	295	11	pathological	pathological	ADJ
fnp-8974	295	12	features	feature	NOUN
fnp-8974	295	13	?	?	PUNCT
fnp-8974	296	1	method(s	method(	VERB
fnp-8974	296	2	):	):	PUNCT
fnp-8974	296	3	we	we	PRON
fnp-8974	296	4	performed	perform	VERB
fnp-8974	296	5	sphingolipid	sphingolipid	NOUN
fnp-8974	296	6	-	-	PUNCT
fnp-8974	296	7	targeted	target	VERB
fnp-8974	296	8	lipidomics	lipidomic	NOUN
fnp-8974	296	9	by	by	ADP
fnp-8974	296	10	lc	lc	PROPN
fnp-8974	296	11	-	-	PUNCT
fnp-8974	296	12	ms	ms	NOUN
fnp-8974	296	13	on	on	ADP
fnp-8974	296	14	gray	gray	ADJ
fnp-8974	296	15	and	and	CCONJ
fnp-8974	296	16	white	white	ADJ
fnp-8974	296	17	matter	matter	NOUN
fnp-8974	296	18	from	from	ADP
fnp-8974	296	19	wild	wild	ADJ
fnp-8974	296	20	type	type	NOUN
fnp-8974	296	21	,	,	PUNCT
fnp-8974	296	22	appps1	appps1	PROPN
fnp-8974	296	23	,	,	PUNCT
fnp-8974	296	24	and	and	CCONJ
fnp-8974	296	25	appps1.il12b-/mice	appps1.il12b-/mice	ADP
fnp-8974	296	26	at	at	ADP
fnp-8974	296	27	4	4	NUM
fnp-8974	296	28	and	and	CCONJ
fnp-8974	296	29	8	8	NUM
fnp-8974	296	30	months	month	NOUN
fnp-8974	296	31	and	and	CCONJ
fnp-8974	296	32	used	use	VERB
fnp-8974	296	33	immunohistochemistry	immunohistochemistry	NOUN
fnp-8974	296	34	to	to	PART
fnp-8974	296	35	evaluate	evaluate	VERB
fnp-8974	296	36	lipid	lipid	NOUN
fnp-8974	296	37	metabolism	metabolism	NOUN
fnp-8974	296	38	-	-	PUNCT
fnp-8974	296	39	related	relate	VERB
fnp-8974	296	40	proteins	protein	NOUN
fnp-8974	296	41	.	.	PUNCT
fnp-8974	297	1	result(s	result(s	NOUN
fnp-8974	297	2	):	):	PUNCT
fnp-8974	297	3	4	4	NUM
fnp-8974	297	4	-	-	PUNCT
fnp-8974	297	5	month	month	NOUN
fnp-8974	297	6	-	-	PUNCT
fnp-8974	297	7	old	old	ADJ
fnp-8974	297	8	appps1	appps1	PROPN
fnp-8974	297	9	mice	mouse	NOUN
fnp-8974	297	10	show	show	VERB
fnp-8974	297	11	distinct	distinct	ADJ
fnp-8974	297	12	lipid	lipid	NOUN
fnp-8974	297	13	profile	profile	NOUN
fnp-8974	297	14	changes	change	NOUN
fnp-8974	297	15	vs.	vs.	ADP
fnp-8974	297	16	wild	wild	ADJ
fnp-8974	297	17	type	type	NOUN
fnp-8974	297	18	mice	mouse	NOUN
fnp-8974	297	19	that	that	PRON
fnp-8974	297	20	diminish	diminish	VERB
fnp-8974	297	21	with	with	ADP
fnp-8974	297	22	disease	disease	NOUN
fnp-8974	297	23	progression	progression	NOUN
fnp-8974	297	24	.	.	PUNCT
fnp-8974	298	1	parvalbumin	parvalbumin	ADJ
fnp-8974	298	2	-	-	PUNCT
fnp-8974	298	3	positive	positive	ADJ
fnp-8974	298	4	(	(	PUNCT
fnp-8974	298	5	pv+	pv+	ADJ
fnp-8974	298	6	)	)	PUNCT
fnp-8974	298	7	interneurons	interneuron	NOUN
fnp-8974	298	8	display	display	NOUN
fnp-8974	298	9	reduced	reduce	VERB
fnp-8974	298	10	lamp+	lamp+	X
fnp-8974	298	11	lysosomes	lysosome	NOUN
fnp-8974	298	12	,	,	PUNCT
fnp-8974	298	13	signaling	signal	VERB
fnp-8974	298	14	impaired	impaired	ADJ
fnp-8974	298	15	metabolism	metabolism	NOUN
fnp-8974	298	16	,	,	PUNCT
fnp-8974	298	17	while	while	SCONJ
fnp-8974	298	18	plin3	plin3	PROPN
fnp-8974	298	19	+	+	SYM
fnp-8974	298	20	lipid	lipid	ADJ
fnp-8974	298	21	droplet	droplet	ADJ
fnp-8974	298	22	levels	level	NOUN
fnp-8974	298	23	remain	remain	VERB
fnp-8974	298	24	stable	stable	ADJ
fnp-8974	298	25	.	.	PUNCT
fnp-8974	299	1	microglia	microglia	NOUN
fnp-8974	299	2	accumulate	accumulate	VERB
fnp-8974	299	3	more	more	ADJ
fnp-8974	299	4	,	,	PUNCT
fnp-8974	299	5	smaller	small	ADJ
fnp-8974	299	6	bodipy+	bodipy+	NOUN
fnp-8974	299	7	lipid	lipid	NOUN
fnp-8974	299	8	droplets	droplet	NOUN
fnp-8974	299	9	in	in	ADP
fnp-8974	299	10	appps1	appps1	PROPN
fnp-8974	299	11	,	,	PUNCT
fnp-8974	299	12	whereas	whereas	SCONJ
fnp-8974	299	13	wild	wild	ADJ
fnp-8974	299	14	type	type	NOUN
fnp-8974	299	15	microglia	microglia	NOUN
fnp-8974	299	16	have	have	VERB
fnp-8974	299	17	fewer	few	ADJ
fnp-8974	299	18	,	,	PUNCT
fnp-8974	299	19	larger	large	ADJ
fnp-8974	299	20	droplets	droplet	NOUN
fnp-8974	299	21	.	.	PUNCT
fnp-8974	300	1	il12b	il12b	PROPN
fnp-8974	300	2	deletion	deletion	NOUN
fnp-8974	300	3	partially	partially	ADV
fnp-8974	300	4	restores	restore	VERB
fnp-8974	300	5	these	these	DET
fnp-8974	300	6	phenotypes	phenotype	NOUN
fnp-8974	300	7	.	.	PUNCT
fnp-8974	301	1	conclusion(s	conclusion(s	NOUN
fnp-8974	301	2	):	):	PUNCT
fnp-8974	301	3	our	our	PRON
fnp-8974	301	4	findings	finding	NOUN
fnp-8974	301	5	support	support	VERB
fnp-8974	301	6	il-12	il-12	NOUN
fnp-8974	301	7	’s	’s	PART
fnp-8974	301	8	role	role	NOUN
fnp-8974	301	9	in	in	ADP
fnp-8974	301	10	neuroinflammation	neuroinflammation	NOUN
fnp-8974	301	11	-	-	PUNCT
fnp-8974	301	12	driven	drive	VERB
fnp-8974	301	13	lipid	lipid	NOUN
fnp-8974	301	14	metabolism	metabolism	NOUN
fnp-8974	301	15	disruption	disruption	NOUN
fnp-8974	301	16	and	and	CCONJ
fnp-8974	301	17	support	support	NOUN
fnp-8974	301	18	il-12	il-12	DET
fnp-8974	301	19	inhibition	inhibition	NOUN
fnp-8974	301	20	as	as	ADP
fnp-8974	301	21	a	a	DET
fnp-8974	301	22	potential	potential	ADJ
fnp-8974	301	23	ad	ad	NOUN
fnp-8974	301	24	therapy	therapy	NOUN
fnp-8974	301	25	.	.	PUNCT
fnp-8974	302	1	p23	p23	PROPN
fnp-8974	302	2	free	free	ADJ
fnp-8974	302	3	neuropathol	neuropathol	NOUN
fnp-8974	302	4	6:17:36	6:17:36	NUM
fnp-8974	302	5	development	development	NOUN
fnp-8974	302	6	and	and	CCONJ
fnp-8974	302	7	validation	validation	NOUN
fnp-8974	302	8	of	of	ADP
fnp-8974	302	9	a	a	DET
fnp-8974	302	10	multiplex	multiplex	NOUN
fnp-8974	302	11	microarray	microarray	NOUN
fnp-8974	302	12	for	for	ADP
fnp-8974	302	13	pathogen	pathogen	NOUN
fnp-8974	302	14	detection	detection	NOUN
fnp-8974	302	15	in	in	ADP
fnp-8974	302	16	paraffin	paraffin	NOUN
fnp-8974	302	17	-	-	PUNCT
fnp-8974	302	18	embedded	embed	VERB
fnp-8974	302	19	cns	cns	NOUN
fnp-8974	302	20	tissue	tissue	NOUN
fnp-8974	302	21	imke	imke	PROPN
fnp-8974	302	22	metz1	metz1	PROPN
fnp-8974	302	23	,	,	PUNCT
fnp-8974	302	24	lidia	lidia	PROPN
fnp-8974	302	25	stork1	stork1	PROPN
fnp-8974	302	26	,	,	PUNCT
fnp-8974	302	27	hannah	hannah	PROPN
fnp-8974	302	28	bernauer1	bernauer1	PROPN
fnp-8974	302	29	,	,	PUNCT
fnp-8974	302	30	selina	selina	PROPN
fnp-8974	302	31	rehländer2	rehländer2	PROPN
fnp-8974	302	32	,	,	PUNCT
fnp-8974	302	33	sandra	sandra	PROPN
fnp-8974	302	34	ehser2	ehser2	PROPN
fnp-8974	302	35	,	,	PUNCT
fnp-8974	302	36	andreas	andreas	PROPN
fnp-8974	302	37	richter2	richter2	VERB
fnp-8974	302	38	1	1	NUM
fnp-8974	302	39	institut	institut	PROPN
fnp-8974	302	40	für	für	PROPN
fnp-8974	302	41	neuropathologie	neuropathologie	PROPN
fnp-8974	302	42	,	,	PUNCT
fnp-8974	302	43	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	302	44	göttingen	göttingen	PROPN
fnp-8974	302	45	,	,	PUNCT
fnp-8974	302	46	göttingen	göttingen	NOUN
fnp-8974	302	47	,	,	PUNCT
fnp-8974	302	48	germany	germany	PROPN
fnp-8974	302	49	2	2	NUM
fnp-8974	302	50	zytovision	zytovision	PROPN
fnp-8974	302	51	,	,	PUNCT
fnp-8974	302	52	bremerhaven	bremerhaven	PROPN
fnp-8974	302	53	,	,	PUNCT
fnp-8974	302	54	germany	germany	PROPN
fnp-8974	302	55	background	background	NOUN
fnp-8974	302	56	:	:	PUNCT
fnp-8974	302	57	inflammatory	inflammatory	ADJ
fnp-8974	302	58	cns	cns	NOUN
fnp-8974	302	59	diseases	disease	NOUN
fnp-8974	302	60	can	can	AUX
fnp-8974	302	61	be	be	AUX
fnp-8974	302	62	caused	cause	VERB
fnp-8974	302	63	by	by	ADP
fnp-8974	302	64	different	different	ADJ
fnp-8974	302	65	pathogens	pathogen	NOUN
fnp-8974	302	66	,	,	PUNCT
fnp-8974	302	67	including	include	VERB
fnp-8974	302	68	viruses	virus	NOUN
fnp-8974	302	69	,	,	PUNCT
fnp-8974	302	70	bacteria	bacteria	NOUN
fnp-8974	302	71	,	,	PUNCT
fnp-8974	302	72	fungi	fungus	NOUN
fnp-8974	302	73	,	,	PUNCT
fnp-8974	302	74	and	and	CCONJ
fnp-8974	302	75	protozoa	protozoan	NOUN
fnp-8974	302	76	.	.	PUNCT
fnp-8974	303	1	differential	differential	NOUN
fnp-8974	303	2	diagnoses	diagnosis	NOUN
fnp-8974	303	3	include	include	VERB
fnp-8974	303	4	autoimmune	autoimmune	ADJ
fnp-8974	303	5	diseases	disease	NOUN
fnp-8974	303	6	that	that	PRON
fnp-8974	303	7	require	require	VERB
fnp-8974	303	8	different	different	ADJ
fnp-8974	303	9	therapeutic	therapeutic	ADJ
fnp-8974	303	10	approaches	approach	NOUN
fnp-8974	303	11	.	.	PUNCT
fnp-8974	304	1	histopathology	histopathology	NOUN
fnp-8974	304	2	may	may	AUX
fnp-8974	304	3	not	not	PART
fnp-8974	304	4	always	always	ADV
fnp-8974	304	5	detect	detect	VERB
fnp-8974	304	6	pathogens	pathogen	NOUN
fnp-8974	304	7	,	,	PUNCT
fnp-8974	304	8	and	and	CCONJ
fnp-8974	304	9	specific	specific	ADJ
fnp-8974	304	10	antibodies	antibody	NOUN
fnp-8974	304	11	or	or	CCONJ
fnp-8974	304	12	stainings	staining	NOUN
fnp-8974	304	13	are	be	AUX
fnp-8974	304	14	not	not	PART
fnp-8974	304	15	available	available	ADJ
fnp-8974	304	16	for	for	ADP
fnp-8974	304	17	all	all	DET
fnp-8974	304	18	pathogens	pathogen	NOUN
fnp-8974	304	19	.	.	PUNCT
fnp-8974	305	1	objective(s	objective(s	NOUN
fnp-8974	305	2	):	):	PUNCT
fnp-8974	305	3	to	to	PART
fnp-8974	305	4	develop	develop	VERB
fnp-8974	305	5	a	a	DET
fnp-8974	305	6	comprehensive	comprehensive	ADJ
fnp-8974	305	7	,	,	PUNCT
fnp-8974	305	8	practical	practical	ADJ
fnp-8974	305	9	test	test	NOUN
fnp-8974	305	10	to	to	PART
fnp-8974	305	11	detect	detect	VERB
fnp-8974	305	12	pathogens	pathogen	NOUN
fnp-8974	305	13	in	in	ADP
fnp-8974	305	14	paraffin	paraffin	NOUN
fnp-8974	305	15	-	-	PUNCT
fnp-8974	305	16	embedded	embed	VERB
fnp-8974	305	17	cns	cns	NOUN
fnp-8974	305	18	tissue	tissue	NOUN
fnp-8974	305	19	.	.	PUNCT
fnp-8974	306	1	method(s	method(	VERB
fnp-8974	306	2	):	):	PUNCT
fnp-8974	306	3	a	a	DET
fnp-8974	306	4	new	new	ADJ
fnp-8974	306	5	cns	cns	PROPN
fnp-8974	306	6	multiplex	multiplex	PROPN
fnp-8974	306	7	microarray	microarray	PROPN
fnp-8974	306	8	chip	chip	NOUN
fnp-8974	306	9	based	base	VERB
fnp-8974	306	10	on	on	ADP
fnp-8974	306	11	the	the	DET
fnp-8974	306	12	visionarray	visionarray	ADJ
fnp-8974	306	13	®	®	NOUN
fnp-8974	306	14	system	system	NOUN
fnp-8974	306	15	is	be	AUX
fnp-8974	306	16	developed	develop	VERB
fnp-8974	306	17	in	in	ADP
fnp-8974	306	18	collaboration	collaboration	NOUN
fnp-8974	306	19	between	between	ADP
fnp-8974	306	20	zytovision	zytovision	NOUN
fnp-8974	306	21	gmbh	gmbh	PROPN
fnp-8974	306	22	(	(	PUNCT
fnp-8974	306	23	a	a	DET
fnp-8974	306	24	zytomics	zytomic	NOUN
fnp-8974	306	25	company	company	NOUN
fnp-8974	306	26	)	)	PUNCT
fnp-8974	306	27	,	,	PUNCT
fnp-8974	306	28	and	and	CCONJ
fnp-8974	306	29	the	the	DET
fnp-8974	306	30	institute	institute	NOUN
fnp-8974	306	31	of	of	ADP
fnp-8974	306	32	neuropathology	neuropathology	NOUN
fnp-8974	306	33	,	,	PUNCT
fnp-8974	306	34	university	university	NOUN
fnp-8974	306	35	medical	medical	ADJ
fnp-8974	306	36	center	center	NOUN
fnp-8974	306	37	göttingen	göttingen	NOUN
fnp-8974	306	38	,	,	PUNCT
fnp-8974	306	39	encompassing	encompass	VERB
fnp-8974	306	40	the	the	DET
fnp-8974	306	41	most	most	ADV
fnp-8974	306	42	important	important	ADJ
fnp-8974	306	43	pathogens	pathogen	NOUN
fnp-8974	306	44	for	for	ADP
fnp-8974	306	45	cns	cns	NOUN
fnp-8974	306	46	infections	infection	NOUN
fnp-8974	306	47	in	in	ADP
fnp-8974	306	48	europe	europe	PROPN
fnp-8974	306	49	.	.	PUNCT
fnp-8974	307	1	result(s	result(s	PROPN
fnp-8974	307	2	):	):	PUNCT
fnp-8974	307	3	high	high	ADJ
fnp-8974	307	4	sensitivity	sensitivity	NOUN
fnp-8974	307	5	was	be	AUX
fnp-8974	307	6	found	find	VERB
fnp-8974	307	7	for	for	ADP
fnp-8974	307	8	toxoplasmosis	toxoplasmosis	NOUN
fnp-8974	307	9	and	and	CCONJ
fnp-8974	307	10	progressive	progressive	ADJ
fnp-8974	307	11	multifocal	multifocal	ADJ
fnp-8974	307	12	leukoencephalopathy	leukoencephalopathy	NOUN
fnp-8974	307	13	(	(	PUNCT
fnp-8974	307	14	9/9	9/9	NUM
fnp-8974	307	15	and	and	CCONJ
fnp-8974	307	16	13/13	13/13	NUM
fnp-8974	307	17	cases	case	NOUN
fnp-8974	307	18	positive	positive	ADJ
fnp-8974	307	19	,	,	PUNCT
fnp-8974	307	20	respectively	respectively	ADV
fnp-8974	307	21	)	)	PUNCT
fnp-8974	307	22	.	.	PUNCT
fnp-8974	308	1	four	four	NUM
fnp-8974	308	2	of	of	ADP
fnp-8974	308	3	five	five	NUM
fnp-8974	308	4	cases	case	NOUN
fnp-8974	308	5	with	with	ADP
fnp-8974	308	6	inflammatory	inflammatory	ADJ
fnp-8974	308	7	necrotic	necrotic	ADJ
fnp-8974	308	8	lesions	lesion	NOUN
fnp-8974	308	9	in	in	ADP
fnp-8974	308	10	immunosuppressed	immunosuppressed	ADJ
fnp-8974	308	11	patients	patient	NOUN
fnp-8974	308	12	suspicious	suspicious	ADJ
fnp-8974	308	13	for	for	ADP
fnp-8974	308	14	toxoplasmosis	toxoplasmosis	NOUN
fnp-8974	308	15	but	but	CCONJ
fnp-8974	308	16	negative	negative	ADJ
fnp-8974	308	17	on	on	ADP
fnp-8974	308	18	immunohistochemistry	immunohistochemistry	NOUN
fnp-8974	308	19	were	be	AUX
fnp-8974	308	20	also	also	ADV
fnp-8974	308	21	positive	positive	ADJ
fnp-8974	308	22	.	.	PUNCT
fnp-8974	309	1	for	for	ADP
fnp-8974	309	2	progressive	progressive	ADJ
fnp-8974	309	3	multifocal	multifocal	ADJ
fnp-8974	309	4	leukoencephalopathy	leukoencephalopathy	NOUN
fnp-8974	309	5	,	,	PUNCT
fnp-8974	309	6	3/4	3/4	NUM
fnp-8974	309	7	cases	case	NOUN
fnp-8974	309	8	suspicious	suspicious	ADJ
fnp-8974	309	9	for	for	ADP
fnp-8974	309	10	pml	pml	NOUN
fnp-8974	309	11	but	but	CCONJ
fnp-8974	309	12	negative	negative	ADJ
fnp-8974	309	13	on	on	ADP
fnp-8974	309	14	conventional	conventional	ADJ
fnp-8974	309	15	testing	testing	NOUN
fnp-8974	309	16	were	be	AUX
fnp-8974	309	17	positive	positive	ADJ
fnp-8974	309	18	.	.	PUNCT
fnp-8974	310	1	no	no	DET
fnp-8974	310	2	false	false	ADJ
fnp-8974	310	3	positive	positive	ADJ
fnp-8974	310	4	results	result	NOUN
fnp-8974	310	5	were	be	AUX
fnp-8974	310	6	found	find	VERB
fnp-8974	310	7	.	.	PUNCT
fnp-8974	311	1	tests	test	NOUN
fnp-8974	311	2	for	for	ADP
fnp-8974	311	3	other	other	ADJ
fnp-8974	311	4	pathogens	pathogen	NOUN
fnp-8974	311	5	still	still	ADV
fnp-8974	311	6	require	require	VERB
fnp-8974	311	7	optimization	optimization	NOUN
fnp-8974	311	8	.	.	PUNCT
fnp-8974	312	1	conclusion(s	conclusion(s	NOUN
fnp-8974	312	2	):	):	PUNCT
fnp-8974	312	3	this	this	DET
fnp-8974	312	4	cns	cns	PROPN
fnp-8974	312	5	microarray	microarray	NOUN
fnp-8974	312	6	shows	show	VERB
fnp-8974	312	7	promise	promise	NOUN
fnp-8974	312	8	for	for	ADP
fnp-8974	312	9	detecting	detect	VERB
fnp-8974	312	10	certain	certain	ADJ
fnp-8974	312	11	pathogens	pathogen	NOUN
fnp-8974	312	12	with	with	ADP
fnp-8974	312	13	high	high	ADJ
fnp-8974	312	14	sensitivity	sensitivity	NOUN
fnp-8974	312	15	and	and	CCONJ
fnp-8974	312	16	specificity	specificity	NOUN
fnp-8974	312	17	,	,	PUNCT
fnp-8974	312	18	providing	provide	VERB
fnp-8974	312	19	clear	clear	ADJ
fnp-8974	312	20	added	add	VERB
fnp-8974	312	21	value	value	NOUN
fnp-8974	312	22	compared	compare	VERB
fnp-8974	312	23	to	to	ADP
fnp-8974	312	24	histopathology	histopathology	NOUN
fnp-8974	312	25	alone	alone	ADV
fnp-8974	312	26	.	.	PUNCT
fnp-8974	313	1	vii	vii	PROPN
fnp-8974	313	2	.	.	PUNCT
fnp-8974	313	3	single	single	ADJ
fnp-8974	313	4	-	-	PUNCT
fnp-8974	313	5	cell	cell	NOUN
fnp-8974	313	6	technologies	technology	NOUN
fnp-8974	313	7	p24	p24	VERB
fnp-8974	313	8	free	free	ADJ
fnp-8974	313	9	neuropathol	neuropathol	NOUN
fnp-8974	314	1	6:17:37	6:17:37	NUM
fnp-8974	314	2	investigation	investigation	NOUN
fnp-8974	314	3	of	of	ADP
fnp-8974	314	4	intratumour	intratumour	NOUN
fnp-8974	314	5	heterogeneity	heterogeneity	NOUN
fnp-8974	314	6	in	in	ADP
fnp-8974	314	7	primary	primary	ADJ
fnp-8974	314	8	and	and	CCONJ
fnp-8974	314	9	recurrent	recurrent	ADJ
fnp-8974	314	10	glioblastoma	glioblastoma	NOUN
fnp-8974	314	11	via	via	ADP
fnp-8974	314	12	single	single	ADJ
fnp-8974	314	13	cell	cell	NOUN
fnp-8974	314	14	whole	whole	ADJ
fnp-8974	314	15	exome	exome	NOUN
fnp-8974	314	16	sequencing	sequence	VERB
fnp-8974	314	17	natalie	natalie	PROPN
fnp-8974	314	18	schoebe1,2	schoebe1,2	PROPN
fnp-8974	314	19	,	,	PUNCT
fnp-8974	314	20	isai	isai	VERB
fnp-8974	314	21	gonzález3	gonzález3	PROPN
fnp-8974	314	22	,	,	PUNCT
fnp-8974	314	23	franziska	franziska	PROPN
fnp-8974	314	24	maria	maria	PROPN
fnp-8974	314	25	ippen4	ippen4	PROPN
fnp-8974	314	26	,	,	PUNCT
fnp-8974	314	27	paul	paul	PROPN
fnp-8974	314	28	kerbs1,2	kerbs1,2	PROPN
fnp-8974	314	29	,	,	PUNCT
fnp-8974	314	30	philipp	philipp	PROPN
fnp-8974	314	31	sievers1,2	sievers1,2	PROPN
fnp-8974	314	32	,	,	PUNCT
fnp-8974	314	33	stefan	stefan	PROPN
fnp-8974	314	34	pfister5,6	pfister5,6	PROPN
fnp-8974	314	35	,	,	PUNCT
fnp-8974	314	36	sandro	sandro	PROPN
fnp-8974	314	37	krieg7	krieg7	PROPN
fnp-8974	314	38	,	,	PUNCT
fnp-8974	314	39	wolfgang	wolfgang	PROPN
fnp-8974	314	40	wick4	wick4	PROPN
fnp-8974	314	41	,	,	PUNCT
fnp-8974	314	42	andreas	andreas	PROPN
fnp-8974	314	43	von	von	PROPN
fnp-8974	314	44	deimling1,2	deimling1,2	PROPN
fnp-8974	314	45	,	,	PUNCT
fnp-8974	314	46	christel	christel	PROPN
fnp-8974	314	47	herold	herold	PROPN
fnp-8974	314	48	-	-	PUNCT
fnp-8974	314	49	mende7	mende7	PROPN
fnp-8974	314	50	,	,	PUNCT
fnp-8974	314	51	supat	supat	PROPN
fnp-8974	315	1	thongjuea6,8	thongjuea6,8	PROPN
fnp-8974	315	2	,	,	PUNCT
fnp-8974	315	3	natalie	natalie	PROPN
fnp-8974	315	4	berghaus1,2	berghaus1,2	PROPN
fnp-8974	315	5	,	,	PUNCT
fnp-8974	315	6	felix	felix	PROPN
fnp-8974	315	7	sahm1,2	sahm1,2	PROPN
fnp-8974	315	8	1	1	NUM
fnp-8974	315	9	university	university	NOUN
fnp-8974	315	10	hospital	hospital	NOUN
fnp-8974	315	11	heidelberg	heidelberg	PROPN
fnp-8974	315	12	,	,	PUNCT
fnp-8974	315	13	department	department	NOUN
fnp-8974	315	14	of	of	ADP
fnp-8974	315	15	neuropathology	neuropathology	NOUN
fnp-8974	315	16	,	,	PUNCT
fnp-8974	315	17	heidelberg	heidelberg	PROPN
fnp-8974	315	18	,	,	PUNCT
fnp-8974	315	19	germany	germany	PROPN
fnp-8974	315	20	2	2	NUM
fnp-8974	315	21	german	german	ADJ
fnp-8974	315	22	cancer	cancer	NOUN
fnp-8974	315	23	research	research	NOUN
fnp-8974	315	24	center	center	NOUN
fnp-8974	315	25	(	(	PUNCT
fnp-8974	315	26	dkfz	dkfz	PROPN
fnp-8974	315	27	)	)	PUNCT
fnp-8974	315	28	,	,	PUNCT
fnp-8974	315	29	german	german	ADJ
fnp-8974	315	30	consortium	consortium	NOUN
fnp-8974	315	31	for	for	ADP
fnp-8974	315	32	translational	translational	ADJ
fnp-8974	315	33	cancer	cancer	NOUN
fnp-8974	315	34	research	research	NOUN
fnp-8974	315	35	(	(	PUNCT
fnp-8974	315	36	dktk	dktk	NOUN
fnp-8974	315	37	)	)	PUNCT
fnp-8974	315	38	,	,	PUNCT
fnp-8974	315	39	clinical	clinical	ADJ
fnp-8974	315	40	cooperation	cooperation	NOUN
fnp-8974	315	41	unit	unit	NOUN
fnp-8974	315	42	neuropathology	neuropathology	NOUN
fnp-8974	315	43	,	,	PUNCT
fnp-8974	315	44	heidelberg	heidelberg	PROPN
fnp-8974	315	45	,	,	PUNCT
fnp-8974	315	46	germany	germany	PROPN
fnp-8974	315	47	3	3	NUM
fnp-8974	315	48	bioskryb	bioskryb	NOUN
fnp-8974	315	49	genomics	genomic	NOUN
fnp-8974	315	50	,	,	PUNCT
fnp-8974	315	51	durham	durham	PROPN
fnp-8974	315	52	,	,	PUNCT
fnp-8974	315	53	united	united	PROPN
fnp-8974	315	54	states	states	PROPN
fnp-8974	315	55	4	4	NUM
fnp-8974	315	56	university	university	NOUN
fnp-8974	315	57	hospital	hospital	NOUN
fnp-8974	315	58	heidelberg	heidelberg	PROPN
fnp-8974	315	59	,	,	PUNCT
fnp-8974	315	60	department	department	NOUN
fnp-8974	315	61	of	of	ADP
fnp-8974	315	62	neurology	neurology	NOUN
fnp-8974	315	63	,	,	PUNCT
fnp-8974	315	64	heidelberg	heidelberg	PROPN
fnp-8974	315	65	,	,	PUNCT
fnp-8974	315	66	germany	germany	PROPN
fnp-8974	315	67	5	5	NUM
fnp-8974	315	68	university	university	PROPN
fnp-8974	315	69	hospital	hospital	NOUN
fnp-8974	315	70	heidelberg	heidelberg	PROPN
fnp-8974	315	71	,	,	PUNCT
fnp-8974	315	72	department	department	NOUN
fnp-8974	315	73	of	of	ADP
fnp-8974	315	74	pediatric	pediatric	ADJ
fnp-8974	315	75	hematology	hematology	NOUN
fnp-8974	315	76	and	and	CCONJ
fnp-8974	315	77	oncology	oncology	NOUN
fnp-8974	315	78	,	,	PUNCT
fnp-8974	315	79	heidelberg	heidelberg	PROPN
fnp-8974	315	80	,	,	PUNCT
fnp-8974	315	81	germany	germany	PROPN
fnp-8974	315	82	6	6	NUM
fnp-8974	315	83	hopp	hopp	PROPN
fnp-8974	315	84	children	children	PROPN
fnp-8974	315	85	's	's	PART
fnp-8974	315	86	cancer	cancer	NOUN
fnp-8974	315	87	center	center	NOUN
fnp-8974	315	88	heidelberg	heidelberg	PROPN
fnp-8974	315	89	(	(	PUNCT
fnp-8974	315	90	kitz	kitz	PROPN
fnp-8974	315	91	)	)	PUNCT
fnp-8974	315	92	,	,	PUNCT
fnp-8974	315	93	heidelberg	heidelberg	PROPN
fnp-8974	315	94	,	,	PUNCT
fnp-8974	315	95	germany	germany	PROPN
fnp-8974	315	96	7	7	NUM
fnp-8974	315	97	university	university	PROPN
fnp-8974	315	98	hospital	hospital	NOUN
fnp-8974	315	99	heidelberg	heidelberg	PROPN
fnp-8974	315	100	,	,	PUNCT
fnp-8974	315	101	department	department	NOUN
fnp-8974	315	102	of	of	ADP
fnp-8974	315	103	neurosurgery	neurosurgery	NOUN
fnp-8974	315	104	,	,	PUNCT
fnp-8974	315	105	heidelberg	heidelberg	PROPN
fnp-8974	315	106	,	,	PUNCT
fnp-8974	315	107	germany	germany	PROPN
fnp-8974	315	108	8	8	NUM
fnp-8974	315	109	german	german	ADJ
fnp-8974	315	110	cancer	cancer	NOUN
fnp-8974	315	111	research	research	NOUN
fnp-8974	315	112	center	center	NOUN
fnp-8974	315	113	(	(	PUNCT
fnp-8974	315	114	dkfz	dkfz	PROPN
fnp-8974	315	115	)	)	PUNCT
fnp-8974	315	116	,	,	PUNCT
fnp-8974	315	117	neurooncology	neurooncology	NOUN
fnp-8974	315	118	(	(	PUNCT
fnp-8974	315	119	b062	b062	NUM
fnp-8974	315	120	)	)	PUNCT
fnp-8974	315	121	,	,	PUNCT
fnp-8974	315	122	heidelberg	heidelberg	PROPN
fnp-8974	315	123	,	,	PUNCT
fnp-8974	315	124	germany	germany	PROPN
fnp-8974	315	125	background	background	NOUN
fnp-8974	315	126	:	:	PUNCT
fnp-8974	315	127	glioblastoma	glioblastoma	NOUN
fnp-8974	315	128	(	(	PUNCT
fnp-8974	315	129	gbm	gbm	PROPN
fnp-8974	315	130	)	)	PUNCT
fnp-8974	315	131	are	be	AUX
fnp-8974	315	132	aggressive	aggressive	ADJ
fnp-8974	315	133	brain	brain	NOUN
fnp-8974	315	134	tumours	tumour	NOUN
fnp-8974	315	135	with	with	ADP
fnp-8974	315	136	high	high	ADJ
fnp-8974	315	137	rates	rate	NOUN
fnp-8974	315	138	of	of	ADP
fnp-8974	315	139	recurrence	recurrence	NOUN
fnp-8974	315	140	,	,	PUNCT
fnp-8974	315	141	likely	likely	ADV
fnp-8974	315	142	driven	drive	VERB
fnp-8974	315	143	by	by	ADP
fnp-8974	315	144	a	a	DET
fnp-8974	315	145	high	high	ADJ
fnp-8974	315	146	level	level	NOUN
fnp-8974	315	147	of	of	ADP
fnp-8974	315	148	intratumour	intratumour	NOUN
fnp-8974	315	149	heterogeneity	heterogeneity	NOUN
fnp-8974	315	150	.	.	PUNCT
fnp-8974	316	1	yet	yet	ADV
fnp-8974	316	2	,	,	PUNCT
fnp-8974	316	3	standard	standard	ADJ
fnp-8974	316	4	dna	dna	NOUN
fnp-8974	316	5	sequencing	sequencing	NOUN
fnp-8974	316	6	methods	method	NOUN
fnp-8974	316	7	do	do	AUX
fnp-8974	316	8	not	not	PART
fnp-8974	316	9	allow	allow	VERB
fnp-8974	316	10	for	for	ADP
fnp-8974	316	11	single	single	ADJ
fnp-8974	316	12	cell	cell	NOUN
fnp-8974	316	13	resolution	resolution	NOUN
fnp-8974	316	14	.	.	PUNCT
fnp-8974	317	1	objective(s	objective(s	NOUN
fnp-8974	317	2	):	):	PUNCT
fnp-8974	317	3	to	to	PART
fnp-8974	317	4	characterize	characterize	VERB
fnp-8974	317	5	subclonal	subclonal	ADJ
fnp-8974	317	6	dynamics	dynamic	NOUN
fnp-8974	317	7	in	in	ADP
fnp-8974	317	8	the	the	DET
fnp-8974	317	9	transition	transition	NOUN
fnp-8974	317	10	from	from	ADP
fnp-8974	317	11	primary	primary	ADJ
fnp-8974	317	12	to	to	PART
fnp-8974	317	13	recurrent	recurrent	VERB
fnp-8974	317	14	tumour	tumour	NOUN
fnp-8974	317	15	and	and	CCONJ
fnp-8974	317	16	uncover	uncover	VERB
fnp-8974	317	17	potential	potential	ADJ
fnp-8974	317	18	mechanisms	mechanism	NOUN
fnp-8974	317	19	of	of	ADP
fnp-8974	317	20	therapy	therapy	NOUN
fnp-8974	317	21	resistance	resistance	NOUN
fnp-8974	317	22	.	.	PUNCT
fnp-8974	318	1	question(s	question(s	PROPN
fnp-8974	318	2	):	):	PUNCT
fnp-8974	318	3	which	which	DET
fnp-8974	318	4	subclones	subclone	NOUN
fnp-8974	318	5	persist	persist	VERB
fnp-8974	318	6	,	,	PUNCT
fnp-8974	318	7	evolve	evolve	VERB
fnp-8974	318	8	or	or	CCONJ
fnp-8974	318	9	emerge	emerge	VERB
fnp-8974	318	10	under	under	ADP
fnp-8974	318	11	therapeutic	therapeutic	ADJ
fnp-8974	318	12	pressure	pressure	NOUN
fnp-8974	318	13	and	and	CCONJ
fnp-8974	318	14	through	through	ADP
fnp-8974	318	15	which	which	PRON
fnp-8974	318	16	molecular	molecular	ADJ
fnp-8974	318	17	mechanisms	mechanism	NOUN
fnp-8974	318	18	do	do	AUX
fnp-8974	318	19	they	they	PRON
fnp-8974	318	20	gain	gain	VERB
fnp-8974	318	21	this	this	DET
fnp-8974	318	22	advantage	advantage	NOUN
fnp-8974	318	23	?	?	PUNCT
fnp-8974	319	1	method(s	method(	VERB
fnp-8974	319	2	):	):	PUNCT
fnp-8974	319	3	primary	primary	ADJ
fnp-8974	319	4	and	and	CCONJ
fnp-8974	319	5	recurrent	recurrent	ADJ
fnp-8974	319	6	gbm	gbm	NOUN
fnp-8974	319	7	samples	sample	NOUN
fnp-8974	319	8	from	from	ADP
fnp-8974	319	9	two	two	NUM
fnp-8974	319	10	patients	patient	NOUN
fnp-8974	319	11	who	who	PRON
fnp-8974	319	12	underwent	undergo	VERB
fnp-8974	319	13	standard	standard	NOUN
fnp-8974	319	14	of	of	ADP
fnp-8974	319	15	care	care	NOUN
fnp-8974	319	16	treatment	treatment	NOUN
fnp-8974	319	17	were	be	AUX
fnp-8974	319	18	analysed	analyse	VERB
fnp-8974	319	19	.	.	PUNCT
fnp-8974	320	1	fresh	fresh	ADJ
fnp-8974	320	2	frozen	frozen	ADJ
fnp-8974	320	3	tumour	tumour	NOUN
fnp-8974	320	4	tissue	tissue	NOUN
fnp-8974	320	5	was	be	AUX
fnp-8974	320	6	dissociated	dissociate	VERB
fnp-8974	320	7	,	,	PUNCT
fnp-8974	320	8	and	and	CCONJ
fnp-8974	320	9	single	single	ADJ
fnp-8974	320	10	nuclei	nucleus	NOUN
fnp-8974	320	11	were	be	AUX
fnp-8974	320	12	sorted	sort	VERB
fnp-8974	320	13	into	into	ADP
fnp-8974	320	14	384	384	NUM
fnp-8974	320	15	-	-	PUNCT
fnp-8974	320	16	well	well	ADJ
fnp-8974	320	17	plates	plate	NOUN
fnp-8974	320	18	for	for	ADP
fnp-8974	320	19	primary	primary	ADJ
fnp-8974	320	20	template	template	NOUN
fnp-8974	320	21	-	-	PUNCT
fnp-8974	320	22	directed	direct	VERB
fnp-8974	320	23	amplification	amplification	NOUN
fnp-8974	320	24	(	(	PUNCT
fnp-8974	320	25	pta	pta	PROPN
fnp-8974	320	26	)	)	PUNCT
fnp-8974	320	27	,	,	PUNCT
fnp-8974	320	28	a	a	DET
fnp-8974	320	29	single	single	ADJ
fnp-8974	320	30	-	-	PUNCT
fnp-8974	320	31	cell	cell	NOUN
fnp-8974	320	32	whole	whole	ADJ
fnp-8974	320	33	genome	genome	NOUN
fnp-8974	320	34	amplification	amplification	NOUN
fnp-8974	320	35	method	method	NOUN
fnp-8974	320	36	enabling	enable	VERB
fnp-8974	320	37	single	single	ADJ
fnp-8974	320	38	nuclei	nucleus	NOUN
fnp-8974	320	39	genome	genome	NOUN
fnp-8974	320	40	(	(	PUNCT
fnp-8974	320	41	snwgs	snwgs	NOUN
fnp-8974	320	42	)	)	PUNCT
fnp-8974	320	43	and	and	CCONJ
fnp-8974	320	44	exome	exome	NOUN
fnp-8974	320	45	sequencing	sequence	VERB
fnp-8974	320	46	(	(	PUNCT
fnp-8974	320	47	snwes	snwe	NOUN
fnp-8974	320	48	)	)	PUNCT
fnp-8974	320	49	while	while	SCONJ
fnp-8974	320	50	ensuring	ensure	VERB
fnp-8974	320	51	uniform	uniform	ADJ
fnp-8974	320	52	genome	genome	NOUN
fnp-8974	320	53	coverage	coverage	NOUN
fnp-8974	320	54	and	and	CCONJ
fnp-8974	320	55	low	low	ADJ
fnp-8974	320	56	amplification	amplification	NOUN
fnp-8974	320	57	bias	bias	NOUN
fnp-8974	320	58	.	.	PUNCT
fnp-8974	321	1	result(s	result(s	NOUN
fnp-8974	321	2	):	):	PUNCT
fnp-8974	321	3	snwgs	snwg	VERB
fnp-8974	321	4	from	from	ADP
fnp-8974	321	5	pair	pair	NOUN
fnp-8974	321	6	1	1	NUM
fnp-8974	321	7	revealed	reveal	VERB
fnp-8974	321	8	canonical	canonical	ADJ
fnp-8974	321	9	chr7	chr7	ADJ
fnp-8974	321	10	gain	gain	NOUN
fnp-8974	321	11	and	and	CCONJ
fnp-8974	321	12	chr10	chr10	ADJ
fnp-8974	321	13	loss	loss	NOUN
fnp-8974	321	14	,	,	PUNCT
fnp-8974	321	15	with	with	ADP
fnp-8974	321	16	additional	additional	ADJ
fnp-8974	321	17	alterations	alteration	NOUN
fnp-8974	321	18	such	such	ADJ
fnp-8974	321	19	as	as	ADP
fnp-8974	321	20	chr3	chr3	NOUN
fnp-8974	321	21	loss	loss	NOUN
fnp-8974	321	22	in	in	ADP
fnp-8974	321	23	the	the	DET
fnp-8974	321	24	recurrent	recurrent	ADJ
fnp-8974	321	25	tumour	tumour	NOUN
fnp-8974	321	26	.	.	PUNCT
fnp-8974	322	1	pair	pair	NOUN
fnp-8974	322	2	2	2	NUM
fnp-8974	322	3	showed	show	VERB
fnp-8974	322	4	a	a	DET
fnp-8974	322	5	shift	shift	NOUN
fnp-8974	322	6	from	from	ADP
fnp-8974	322	7	partial	partial	ADJ
fnp-8974	322	8	to	to	ADP
fnp-8974	322	9	a	a	DET
fnp-8974	322	10	full	full	ADJ
fnp-8974	322	11	7/10	7/10	NUM
fnp-8974	322	12	signature	signature	NOUN
fnp-8974	322	13	,	,	PUNCT
fnp-8974	322	14	with	with	ADP
fnp-8974	322	15	other	other	ADJ
fnp-8974	322	16	unique	unique	ADJ
fnp-8974	322	17	changes	change	NOUN
fnp-8974	322	18	between	between	ADP
fnp-8974	322	19	states	state	NOUN
fnp-8974	322	20	.	.	PUNCT
fnp-8974	323	1	for	for	ADP
fnp-8974	323	2	example	example	NOUN
fnp-8974	323	3	,	,	PUNCT
fnp-8974	323	4	the	the	DET
fnp-8974	323	5	primary	primary	ADJ
fnp-8974	323	6	tumour	tumour	NOUN
fnp-8974	323	7	harboured	harbour	VERB
fnp-8974	323	8	a	a	DET
fnp-8974	323	9	chr22	chr22	PROPN
fnp-8974	323	10	loss	loss	NOUN
fnp-8974	323	11	that	that	PRON
fnp-8974	323	12	was	be	AUX
fnp-8974	323	13	not	not	PART
fnp-8974	323	14	present	present	ADJ
fnp-8974	323	15	in	in	ADP
fnp-8974	323	16	the	the	DET
fnp-8974	323	17	recurrent	recurrent	ADJ
fnp-8974	323	18	sample	sample	NOUN
fnp-8974	323	19	which	which	PRON
fnp-8974	323	20	,	,	PUNCT
fnp-8974	323	21	in	in	ADP
fnp-8974	323	22	turn	turn	NOUN
fnp-8974	323	23	,	,	PUNCT
fnp-8974	323	24	presented	present	VERB
fnp-8974	323	25	a	a	DET
fnp-8974	323	26	chr11q	chr11q	NOUN
fnp-8974	323	27	loss	loss	NOUN
fnp-8974	323	28	.	.	PUNCT
fnp-8974	324	1	conclusion(s	conclusion(s	NOUN
fnp-8974	324	2	):	):	PUNCT
fnp-8974	324	3	pta	pta	NOUN
fnp-8974	324	4	snwgs	snwg	VERB
fnp-8974	324	5	cnv	cnv	PROPN
fnp-8974	324	6	profiling	profiling	NOUN
fnp-8974	324	7	detects	detect	NOUN
fnp-8974	324	8	subtle	subtle	ADJ
fnp-8974	324	9	genomic	genomic	ADJ
fnp-8974	324	10	changes	change	NOUN
fnp-8974	324	11	:	:	PUNCT
fnp-8974	324	12	overall	overall	ADV
fnp-8974	324	13	,	,	PUNCT
fnp-8974	324	14	the	the	DET
fnp-8974	324	15	primary	primary	ADJ
fnp-8974	324	16	tumours	tumour	NOUN
fnp-8974	324	17	showed	show	VERB
fnp-8974	324	18	more	more	ADJ
fnp-8974	324	19	subclonal	subclonal	ADJ
fnp-8974	324	20	alterations	alteration	NOUN
fnp-8974	324	21	than	than	ADP
fnp-8974	324	22	the	the	DET
fnp-8974	324	23	recurrent	recurrent	ADJ
fnp-8974	324	24	ones	one	NOUN
fnp-8974	324	25	,	,	PUNCT
fnp-8974	324	26	suggesting	suggest	VERB
fnp-8974	324	27	an	an	DET
fnp-8974	324	28	evolutionary	evolutionary	ADJ
fnp-8974	324	29	selection	selection	NOUN
fnp-8974	324	30	for	for	ADP
fnp-8974	324	31	certain	certain	ADJ
fnp-8974	324	32	treatment	treatment	NOUN
fnp-8974	324	33	resistant	resistant	ADJ
fnp-8974	324	34	subclones	subclone	NOUN
fnp-8974	324	35	after	after	ADP
fnp-8974	324	36	recurrence	recurrence	NOUN
fnp-8974	324	37	.	.	PUNCT
fnp-8974	325	1	additional	additional	ADJ
fnp-8974	325	2	snwes	snwe	NOUN
fnp-8974	325	3	will	will	AUX
fnp-8974	325	4	provide	provide	VERB
fnp-8974	325	5	more	more	ADJ
fnp-8974	325	6	insight	insight	NOUN
fnp-8974	325	7	into	into	ADP
fnp-8974	325	8	treatment	treatment	NOUN
fnp-8974	325	9	-	-	PUNCT
fnp-8974	325	10	resistant	resistant	ADJ
fnp-8974	325	11	tumour	tumour	NOUN
fnp-8974	325	12	clones	clone	NOUN
fnp-8974	325	13	and	and	CCONJ
fnp-8974	325	14	their	their	PRON
fnp-8974	325	15	mutations	mutation	NOUN
fnp-8974	325	16	and	and	CCONJ
fnp-8974	325	17	mutational	mutational	ADJ
fnp-8974	325	18	signatures	signature	NOUN
fnp-8974	325	19	.	.	PUNCT
fnp-8974	326	1	p25	p25	PROPN
fnp-8974	326	2	free	free	ADJ
fnp-8974	326	3	neuropathol	neuropathol	NOUN
fnp-8974	326	4	6:17:39	6:17:39	NUM
fnp-8974	326	5	exploring	explore	VERB
fnp-8974	326	6	interand	interand	NOUN
fnp-8974	326	7	intratumoral	intratumoral	ADJ
fnp-8974	326	8	heterogeneity	heterogeneity	NOUN
fnp-8974	326	9	of	of	ADP
fnp-8974	326	10	choroid	choroid	NOUN
fnp-8974	326	11	plexus	plexus	NOUN
fnp-8974	326	12	tumors	tumor	NOUN
fnp-8974	326	13	on	on	ADP
fnp-8974	326	14	a	a	DET
fnp-8974	326	15	single	single	ADJ
fnp-8974	326	16	cell	cell	NOUN
fnp-8974	326	17	level	level	NOUN
fnp-8974	326	18	anna	anna	NOUN
fnp-8974	326	19	klötergens1	klötergens1	PROPN
fnp-8974	326	20	,	,	PUNCT
fnp-8974	326	21	flavia	flavia	PROPN
fnp-8974	326	22	de	de	PROPN
fnp-8974	326	23	faria1	faria1	PROPN
fnp-8974	326	24	,	,	PUNCT
fnp-8974	326	25	clara	clara	PROPN
fnp-8974	326	26	singla2	singla2	PROPN
fnp-8974	326	27	,	,	PUNCT
fnp-8974	326	28	archana	archana	PROPN
fnp-8974	326	29	verma1	verma1	PROPN
fnp-8974	326	30	,	,	PUNCT
fnp-8974	326	31	thomas	thomas	PROPN
fnp-8974	326	32	albert1	albert1	PROPN
fnp-8974	326	33	,	,	PUNCT
fnp-8974	326	34	i	i	PRON
fnp-8974	326	35	-	-	PUNCT
fnp-8974	326	36	na	na	PART
fnp-8974	326	37	lu1	lu1	PROPN
fnp-8974	326	38	,	,	PUNCT
fnp-8974	326	39	uwe	uwe	PROPN
fnp-8974	326	40	kordes3	kordes3	PROPN
fnp-8974	326	41	,	,	PUNCT
fnp-8974	326	42	denise	denise	PROPN
fnp-8974	326	43	obrecht	obrecht	PROPN
fnp-8974	326	44	-	-	PUNCT
fnp-8974	326	45	sturm3	sturm3	NOUN
fnp-8974	326	46	,	,	PUNCT
fnp-8974	326	47	christian	christian	PROPN
fnp-8974	326	48	thomas4	thomas4	PROPN
fnp-8974	326	49	,	,	PUNCT
fnp-8974	326	50	kornelius	kornelius	ADJ
fnp-8974	326	51	kerl1	kerl1	NOUN
fnp-8974	326	52	1	1	NUM
fnp-8974	326	53	department	department	NOUN
fnp-8974	326	54	of	of	ADP
fnp-8974	326	55	pediatric	pediatric	ADJ
fnp-8974	326	56	hematology	hematology	NOUN
fnp-8974	326	57	and	and	CCONJ
fnp-8974	326	58	oncology	oncology	NOUN
fnp-8974	326	59	,	,	PUNCT
fnp-8974	326	60	university	university	NOUN
fnp-8974	326	61	children	child	NOUN
fnp-8974	326	62	’s	’s	PART
fnp-8974	326	63	hospital	hospital	NOUN
fnp-8974	326	64	münster	münster	NOUN
fnp-8974	326	65	,	,	PUNCT
fnp-8974	326	66	münster	münster	PROPN
fnp-8974	326	67	,	,	PUNCT
fnp-8974	326	68	germany	germany	PROPN
fnp-8974	326	69	2	2	NUM
fnp-8974	326	70	institute	institute	PROPN
fnp-8974	326	71	of	of	ADP
fnp-8974	326	72	medical	medical	ADJ
fnp-8974	326	73	informatics	informatics	PROPN
fnp-8974	326	74	,	,	PUNCT
fnp-8974	326	75	university	university	NOUN
fnp-8974	326	76	of	of	ADP
fnp-8974	326	77	münster	münster	NOUN
fnp-8974	326	78	,	,	PUNCT
fnp-8974	326	79	münster	münster	PROPN
fnp-8974	326	80	,	,	PUNCT
fnp-8974	326	81	germany	germany	PROPN
fnp-8974	326	82	3	3	NUM
fnp-8974	326	83	department	department	PROPN
fnp-8974	326	84	of	of	ADP
fnp-8974	326	85	pediatric	pediatric	ADJ
fnp-8974	326	86	hematology	hematology	NOUN
fnp-8974	326	87	and	and	CCONJ
fnp-8974	326	88	oncology	oncology	NOUN
fnp-8974	326	89	,	,	PUNCT
fnp-8974	326	90	university	university	NOUN
fnp-8974	326	91	medical	medical	ADJ
fnp-8974	326	92	center	center	PROPN
fnp-8974	326	93	hamburg	hamburg	PROPN
fnp-8974	326	94	-	-	PUNCT
fnp-8974	326	95	eppendorf	eppendorf	PROPN
fnp-8974	326	96	,	,	PUNCT
fnp-8974	326	97	hamburg	hamburg	PROPN
fnp-8974	326	98	,	,	PUNCT
fnp-8974	326	99	germany	germany	PROPN
fnp-8974	326	100	4	4	NUM
fnp-8974	326	101	institute	institute	PROPN
fnp-8974	326	102	of	of	ADP
fnp-8974	326	103	neuropathology	neuropathology	NOUN
fnp-8974	326	104	,	,	PUNCT
fnp-8974	326	105	university	university	NOUN
fnp-8974	326	106	hospital	hospital	NOUN
fnp-8974	326	107	münster	münster	NOUN
fnp-8974	326	108	,	,	PUNCT
fnp-8974	326	109	münster	münster	PROPN
fnp-8974	326	110	,	,	PUNCT
fnp-8974	326	111	germany	germany	PROPN
fnp-8974	326	112	background	background	NOUN
fnp-8974	326	113	:	:	PUNCT
fnp-8974	326	114	choroid	choroid	NOUN
fnp-8974	326	115	plexus	plexus	NOUN
fnp-8974	326	116	tumors	tumor	NOUN
fnp-8974	326	117	(	(	PUNCT
fnp-8974	326	118	cpts	cpt	NOUN
fnp-8974	326	119	)	)	PUNCT
fnp-8974	326	120	are	be	AUX
fnp-8974	326	121	rare	rare	ADJ
fnp-8974	326	122	intraventricular	intraventricular	ADJ
fnp-8974	326	123	neoplasms	neoplasm	NOUN
fnp-8974	326	124	arising	arise	VERB
fnp-8974	326	125	from	from	ADP
fnp-8974	326	126	choroid	choroid	NOUN
fnp-8974	326	127	plexus	plexus	NOUN
fnp-8974	326	128	(	(	PUNCT
fnp-8974	326	129	chp	chp	NOUN
fnp-8974	326	130	)	)	PUNCT
fnp-8974	326	131	epithelial	epithelial	ADJ
fnp-8974	326	132	cells	cell	NOUN
fnp-8974	326	133	,	,	PUNCT
fnp-8974	326	134	predominantly	predominantly	ADV
fnp-8974	326	135	affecting	affect	VERB
fnp-8974	326	136	children	child	NOUN
fnp-8974	326	137	.	.	PUNCT
fnp-8974	327	1	they	they	PRON
fnp-8974	327	2	include	include	VERB
fnp-8974	327	3	three	three	NUM
fnp-8974	327	4	histological	histological	ADJ
fnp-8974	327	5	subtypes	subtype	NOUN
fnp-8974	327	6	:	:	PUNCT
fnp-8974	327	7	choroid	choroid	NOUN
fnp-8974	327	8	plexus	plexus	NOUN
fnp-8974	327	9	papilloma	papilloma	NOUN
fnp-8974	327	10	(	(	PUNCT
fnp-8974	327	11	cpp	cpp	NOUN
fnp-8974	327	12	)	)	PUNCT
fnp-8974	327	13	,	,	PUNCT
fnp-8974	327	14	atypical	atypical	ADJ
fnp-8974	327	15	cpp	cpp	NOUN
fnp-8974	327	16	(	(	PUNCT
fnp-8974	327	17	acpp	acpp	PROPN
fnp-8974	327	18	)	)	PUNCT
fnp-8974	327	19	,	,	PUNCT
fnp-8974	327	20	and	and	CCONJ
fnp-8974	327	21	choroid	choroid	NOUN
fnp-8974	327	22	plexus	plexus	NOUN
fnp-8974	327	23	carcinoma	carcinoma	NOUN
fnp-8974	327	24	(	(	PUNCT
fnp-8974	327	25	cpc	cpc	PROPN
fnp-8974	327	26	)	)	PUNCT
fnp-8974	327	27	,	,	PUNCT
fnp-8974	327	28	and	and	CCONJ
fnp-8974	327	29	cluster	cluster	NOUN
fnp-8974	327	30	into	into	ADP
fnp-8974	327	31	three	three	NUM
fnp-8974	327	32	epigenetic	epigenetic	ADJ
fnp-8974	327	33	groups	group	NOUN
fnp-8974	327	34	:	:	PUNCT
fnp-8974	327	35	pediatric	pediatric	ADJ
fnp-8974	327	36	a	a	PRON
fnp-8974	327	37	,	,	PUNCT
fnp-8974	327	38	pediatric	pediatric	ADJ
fnp-8974	327	39	b	b	NOUN
fnp-8974	327	40	,	,	PUNCT
fnp-8974	327	41	and	and	CCONJ
fnp-8974	327	42	adult	adult	NOUN
fnp-8974	327	43	.	.	PUNCT
fnp-8974	328	1	objectives	objective	NOUN
fnp-8974	328	2	:	:	PUNCT
fnp-8974	328	3	we	we	PRON
fnp-8974	328	4	aimed	aim	VERB
fnp-8974	328	5	to	to	PART
fnp-8974	328	6	elucidate	elucidate	VERB
fnp-8974	328	7	the	the	DET
fnp-8974	328	8	cellular	cellular	ADJ
fnp-8974	328	9	composition	composition	NOUN
fnp-8974	328	10	and	and	CCONJ
fnp-8974	328	11	molecular	molecular	ADJ
fnp-8974	328	12	underpinnings	underpinning	NOUN
fnp-8974	328	13	of	of	ADP
fnp-8974	328	14	cpts	cpt	NOUN
fnp-8974	328	15	across	across	ADP
fnp-8974	328	16	histological	histological	ADJ
fnp-8974	328	17	and	and	CCONJ
fnp-8974	328	18	epigenetic	epigenetic	ADJ
fnp-8974	328	19	subtypes	subtype	NOUN
fnp-8974	328	20	.	.	PUNCT
fnp-8974	329	1	methods	method	NOUN
fnp-8974	329	2	:	:	PUNCT
fnp-8974	329	3	single	single	ADJ
fnp-8974	329	4	-	-	PUNCT
fnp-8974	329	5	cell	cell	NOUN
fnp-8974	329	6	transcriptomics	transcriptomic	NOUN
fnp-8974	329	7	was	be	AUX
fnp-8974	329	8	applied	apply	VERB
fnp-8974	329	9	to	to	ADP
fnp-8974	329	10	43	43	NUM
fnp-8974	329	11	cpts	cpt	NOUN
fnp-8974	329	12	spanning	span	VERB
fnp-8974	329	13	all	all	DET
fnp-8974	329	14	histological	histological	ADJ
fnp-8974	329	15	and	and	CCONJ
fnp-8974	329	16	epigenetic	epigenetic	ADJ
fnp-8974	329	17	subtypes	subtype	NOUN
fnp-8974	329	18	,	,	PUNCT
fnp-8974	329	19	alongside	alongside	ADP
fnp-8974	329	20	12	12	NUM
fnp-8974	329	21	normal	normal	ADJ
fnp-8974	329	22	chp	chp	NOUN
fnp-8974	329	23	samples	sample	NOUN
fnp-8974	329	24	.	.	PUNCT
fnp-8974	330	1	spatial	spatial	ADJ
fnp-8974	330	2	transcriptomics	transcriptomic	NOUN
fnp-8974	330	3	was	be	AUX
fnp-8974	330	4	conducted	conduct	VERB
fnp-8974	330	5	on	on	ADP
fnp-8974	330	6	15	15	NUM
fnp-8974	330	7	tumors	tumor	NOUN
fnp-8974	330	8	and	and	CCONJ
fnp-8974	330	9	2	2	NUM
fnp-8974	330	10	non	non	ADJ
fnp-8974	330	11	-	-	ADJ
fnp-8974	330	12	neoplastic	neoplastic	ADJ
fnp-8974	330	13	chp	chp	NOUN
fnp-8974	330	14	samples	sample	NOUN
fnp-8974	330	15	.	.	PUNCT
fnp-8974	331	1	integration	integration	NOUN
fnp-8974	331	2	with	with	ADP
fnp-8974	331	3	fetal	fetal	ADJ
fnp-8974	331	4	,	,	PUNCT
fnp-8974	331	5	pediatric	pediatric	ADJ
fnp-8974	331	6	,	,	PUNCT
fnp-8974	331	7	and	and	CCONJ
fnp-8974	331	8	adult	adult	NOUN
fnp-8974	331	9	chp	chp	NOUN
fnp-8974	331	10	tissue	tissue	NOUN
fnp-8974	331	11	enabled	enable	VERB
fnp-8974	331	12	the	the	DET
fnp-8974	331	13	creation	creation	NOUN
fnp-8974	331	14	of	of	ADP
fnp-8974	331	15	a	a	DET
fnp-8974	331	16	comprehensive	comprehensive	ADJ
fnp-8974	331	17	single	single	ADJ
fnp-8974	331	18	-	-	PUNCT
fnp-8974	331	19	cell	cell	NOUN
fnp-8974	331	20	atlas	atlas	PROPN
fnp-8974	331	21	of	of	ADP
fnp-8974	331	22	human	human	ADJ
fnp-8974	331	23	chp	chp	NOUN
fnp-8974	331	24	cells	cell	NOUN
fnp-8974	331	25	,	,	PUNCT
fnp-8974	331	26	illuminating	illuminate	VERB
fnp-8974	331	27	developmental	developmental	ADJ
fnp-8974	331	28	and	and	CCONJ
fnp-8974	331	29	tumor	tumor	NOUN
fnp-8974	331	30	-	-	PUNCT
fnp-8974	331	31	related	relate	VERB
fnp-8974	331	32	transcriptional	transcriptional	ADJ
fnp-8974	331	33	programs	program	NOUN
fnp-8974	331	34	.	.	PUNCT
fnp-8974	332	1	results	result	NOUN
fnp-8974	332	2	:	:	PUNCT
fnp-8974	332	3	our	our	PRON
fnp-8974	332	4	analyses	analysis	NOUN
fnp-8974	332	5	revealed	reveal	VERB
fnp-8974	332	6	distinct	distinct	ADJ
fnp-8974	332	7	molecular	molecular	ADJ
fnp-8974	332	8	profiles	profile	NOUN
fnp-8974	332	9	by	by	ADP
fnp-8974	332	10	subtype	subtype	NOUN
fnp-8974	332	11	and	and	CCONJ
fnp-8974	332	12	treatment	treatment	NOUN
fnp-8974	332	13	status	status	NOUN
fnp-8974	332	14	.	.	PUNCT
fnp-8974	333	1	notably	notably	ADV
fnp-8974	333	2	,	,	PUNCT
fnp-8974	333	3	pediatric	pediatric	ADJ
fnp-8974	333	4	b	b	PROPN
fnp-8974	333	5	papillomas	papilloma	NOUN
fnp-8974	333	6	resembled	resemble	VERB
fnp-8974	333	7	carcinomas	carcinoma	NOUN
fnp-8974	333	8	more	more	ADV
fnp-8974	333	9	than	than	ADP
fnp-8974	333	10	other	other	ADJ
fnp-8974	333	11	papillomas	papilloma	NOUN
fnp-8974	333	12	,	,	PUNCT
fnp-8974	333	13	sharing	share	VERB
fnp-8974	333	14	signaling	signal	VERB
fnp-8974	333	15	pathway	pathway	NOUN
fnp-8974	333	16	enrichment	enrichment	NOUN
fnp-8974	333	17	,	,	PUNCT
fnp-8974	333	18	loss	loss	NOUN
fnp-8974	333	19	of	of	ADP
fnp-8974	333	20	motile	motile	ADJ
fnp-8974	333	21	cilia	cilium	NOUN
fnp-8974	333	22	,	,	PUNCT
fnp-8974	333	23	and	and	CCONJ
fnp-8974	333	24	similar	similar	ADJ
fnp-8974	333	25	cnv	cnv	NOUN
fnp-8974	333	26	patterns	pattern	NOUN
fnp-8974	333	27	.	.	PUNCT
fnp-8974	334	1	spatial	spatial	ADJ
fnp-8974	334	2	transcriptomics	transcriptomic	NOUN
fnp-8974	334	3	uncovered	uncover	VERB
fnp-8974	334	4	organized	organize	VERB
fnp-8974	334	5	myeloid	myeloid	ADJ
fnp-8974	334	6	populations	population	NOUN
fnp-8974	334	7	with	with	ADP
fnp-8974	334	8	subtype	subtype	NOUN
fnp-8974	334	9	-	-	PUNCT
fnp-8974	334	10	specific	specific	ADJ
fnp-8974	334	11	gene	gene	NOUN
fnp-8974	334	12	signatures	signature	NOUN
fnp-8974	334	13	,	,	PUNCT
fnp-8974	334	14	implicating	implicate	VERB
fnp-8974	334	15	them	they	PRON
fnp-8974	334	16	in	in	ADP
fnp-8974	334	17	tumor	tumor	NOUN
fnp-8974	334	18	-	-	PUNCT
fnp-8974	334	19	stroma	stroma	ADJ
fnp-8974	334	20	interactions	interaction	NOUN
fnp-8974	334	21	.	.	PUNCT
fnp-8974	335	1	notably	notably	ADV
fnp-8974	335	2	,	,	PUNCT
fnp-8974	335	3	both	both	CCONJ
fnp-8974	335	4	cpc	cpc	NOUN
fnp-8974	335	5	-	-	PUNCT
fnp-8974	335	6	associated	associate	VERB
fnp-8974	335	7	myeloid	myeloid	NOUN
fnp-8974	335	8	and	and	CCONJ
fnp-8974	335	9	tumor	tumor	NOUN
fnp-8974	335	10	cells	cell	NOUN
fnp-8974	335	11	exhibited	exhibit	VERB
fnp-8974	335	12	enhanced	enhance	VERB
fnp-8974	335	13	interferon	interferon	ADJ
fnp-8974	335	14	signaling	signaling	NOUN
fnp-8974	335	15	,	,	PUNCT
fnp-8974	335	16	which	which	PRON
fnp-8974	335	17	decreased	decrease	VERB
fnp-8974	335	18	following	follow	VERB
fnp-8974	335	19	treatment	treatment	NOUN
fnp-8974	335	20	.	.	PUNCT
fnp-8974	336	1	this	this	DET
fnp-8974	336	2	reduction	reduction	NOUN
fnp-8974	336	3	aligns	align	VERB
fnp-8974	336	4	with	with	ADP
fnp-8974	336	5	our	our	PRON
fnp-8974	336	6	observation	observation	NOUN
fnp-8974	336	7	that	that	PRON
fnp-8974	336	8	treated	treat	VERB
fnp-8974	336	9	cpc	cpc	PROPN
fnp-8974	336	10	cells	cell	NOUN
fnp-8974	336	11	cease	cease	VERB
fnp-8974	336	12	cycling	cycling	NOUN
fnp-8974	336	13	and	and	CCONJ
fnp-8974	336	14	regain	regain	VERB
fnp-8974	336	15	ciliary	ciliary	ADJ
fnp-8974	336	16	function	function	NOUN
fnp-8974	336	17	,	,	PUNCT
fnp-8974	336	18	suggesting	suggest	VERB
fnp-8974	336	19	a	a	DET
fnp-8974	336	20	profound	profound	ADJ
fnp-8974	336	21	molecular	molecular	ADJ
fnp-8974	336	22	reprogramming	reprogramming	NOUN
fnp-8974	336	23	.	.	PUNCT
fnp-8974	337	1	conclusion	conclusion	NOUN
fnp-8974	337	2	:	:	PUNCT
fnp-8974	337	3	this	this	DET
fnp-8974	337	4	study	study	NOUN
fnp-8974	337	5	reveals	reveal	VERB
fnp-8974	337	6	previously	previously	ADV
fnp-8974	337	7	unexplored	unexplored	ADJ
fnp-8974	337	8	aspects	aspect	NOUN
fnp-8974	337	9	of	of	ADP
fnp-8974	337	10	cpt	cpt	NOUN
fnp-8974	337	11	biology	biology	NOUN
fnp-8974	337	12	,	,	PUNCT
fnp-8974	337	13	providing	provide	VERB
fnp-8974	337	14	novel	novel	ADJ
fnp-8974	337	15	insights	insight	NOUN
fnp-8974	337	16	into	into	ADP
fnp-8974	337	17	the	the	DET
fnp-8974	337	18	cellular	cellular	ADJ
fnp-8974	337	19	and	and	CCONJ
fnp-8974	337	20	spatial	spatial	ADJ
fnp-8974	337	21	heterogeneity	heterogeneity	NOUN
fnp-8974	337	22	of	of	ADP
fnp-8974	337	23	cpt	cpt	PROPN
fnp-8974	337	24	subtypes	subtype	NOUN
fnp-8974	337	25	,	,	PUNCT
fnp-8974	337	26	thereby	thereby	ADV
fnp-8974	337	27	paving	pave	VERB
fnp-8974	337	28	the	the	DET
fnp-8974	337	29	way	way	NOUN
fnp-8974	337	30	toward	toward	ADP
fnp-8974	337	31	more	more	ADV
fnp-8974	337	32	personalized	personalized	ADJ
fnp-8974	337	33	and	and	CCONJ
fnp-8974	337	34	effective	effective	ADJ
fnp-8974	337	35	treatment	treatment	NOUN
fnp-8974	337	36	strategies	strategy	NOUN
fnp-8974	337	37	for	for	ADP
fnp-8974	337	38	patients	patient	NOUN
fnp-8974	337	39	with	with	ADP
fnp-8974	337	40	cpt	cpt	PROPN
fnp-8974	337	41	.	.	PUNCT
fnp-8974	337	42	viii	viii	PROPN
fnp-8974	337	43	.	.	PUNCT
fnp-8974	338	1	tumor	tumor	NOUN
fnp-8974	338	2	p26	p26	NOUN
fnp-8974	338	3	free	free	ADJ
fnp-8974	338	4	neuropathol	neuropathol	NOUN
fnp-8974	338	5	6:17:40	6:17:40	NUM
fnp-8974	338	6	analysis	analysis	NOUN
fnp-8974	338	7	of	of	ADP
fnp-8974	338	8	histological	histological	ADJ
fnp-8974	338	9	,	,	PUNCT
fnp-8974	338	10	molecular	molecular	ADJ
fnp-8974	338	11	and	and	CCONJ
fnp-8974	338	12	preanalytic	preanalytic	ADJ
fnp-8974	338	13	features	feature	NOUN
fnp-8974	338	14	of	of	ADP
fnp-8974	338	15	unclassifiable	unclassifiable	ADJ
fnp-8974	338	16	cns	cns	NOUN
fnp-8974	338	17	specimens	specimen	NOUN
fnp-8974	338	18	:	:	PUNCT
fnp-8974	338	19	comparison	comparison	NOUN
fnp-8974	338	20	of	of	ADP
fnp-8974	338	21	the	the	DET
fnp-8974	338	22	heidelberg	heidelberg	PROPN
fnp-8974	338	23	v12.8e	v12.8e	PROPN
fnp-8974	338	24	,	,	PUNCT
fnp-8974	338	25	bethesda	bethesda	PROPN
fnp-8974	338	26	v3	v3	PROPN
fnp-8974	338	27	methylation	methylation	NOUN
fnp-8974	338	28	-	-	PUNCT
fnp-8974	338	29	based	base	VERB
fnp-8974	338	30	brain	brain	NOUN
fnp-8974	338	31	tumor	tumor	NOUN
fnp-8974	338	32	classifiers	classifier	NOUN
fnp-8974	338	33	and	and	CCONJ
fnp-8974	338	34	the	the	DET
fnp-8974	338	35	hetairos	hetairos	PROPN
fnp-8974	338	36	h&e	h&e	PROPN
fnp-8974	338	37	histology	histology	NOUN
fnp-8974	338	38	-	-	PUNCT
fnp-8974	338	39	based	base	VERB
fnp-8974	338	40	classifier	classifier	PROPN
fnp-8974	338	41	charlotte	charlotte	PROPN
fnp-8974	338	42	brandenburg1	brandenburg1	PROPN
fnp-8974	338	43	,	,	PUNCT
fnp-8974	338	44	akash	akash	PROPN
fnp-8974	338	45	kumar1	kumar1	PROPN
fnp-8974	338	46	,	,	PUNCT
fnp-8974	338	47	tatjana	tatjana	PROPN
fnp-8974	338	48	starzetz1	starzetz1	PROPN
fnp-8974	338	49	,	,	PUNCT
fnp-8974	338	50	patricia	patricia	PROPN
fnp-8974	338	51	amlung2	amlung2	PROPN
fnp-8974	338	52	,	,	PUNCT
fnp-8974	338	53	antje	antje	PROPN
fnp-8974	338	54	habel3	habel3	NOUN
fnp-8974	338	55	,	,	PUNCT
fnp-8974	338	56	merten	merten	ADJ
fnp-8974	338	57	bohn1	bohn1	NOUN
fnp-8974	338	58	,	,	PUNCT
fnp-8974	338	59	helena	helena	PROPN
fnp-8974	338	60	radbruch4	radbruch4	PROPN
fnp-8974	338	61	,	,	PUNCT
fnp-8974	338	62	anna	anna	PROPN
fnp-8974	338	63	luger5	luger5	PROPN
fnp-8974	338	64	,	,	PUNCT
fnp-8974	338	65	omkar	omkar	NOUN
fnp-8974	338	66	singh6	singh6	PROPN
fnp-8974	338	67	,	,	PUNCT
fnp-8974	338	68	artem	artem	PROPN
fnp-8974	338	69	shmatko7	shmatko7	PROPN
fnp-8974	338	70	,	,	PUNCT
fnp-8974	338	71	moritz	moritz	PROPN
fnp-8974	338	72	gerstung7	gerstung7	PROPN
fnp-8974	338	73	,	,	PUNCT
fnp-8974	338	74	kenneth	kenneth	PROPN
fnp-8974	338	75	d	d	PROPN
fnp-8974	338	76	aldape7	aldape7	PROPN
fnp-8974	338	77	,	,	PUNCT
fnp-8974	338	78	leonille	leonille	NOUN
fnp-8974	338	79	schweizer1,3	schweizer1,3	PROPN
fnp-8974	338	80	1	1	NUM
fnp-8974	338	81	institute	institute	NOUN
fnp-8974	338	82	of	of	ADP
fnp-8974	338	83	neurology	neurology	NOUN
fnp-8974	338	84	(	(	PUNCT
fnp-8974	338	85	edinger	edinger	PROPN
fnp-8974	338	86	institute	institute	PROPN
fnp-8974	338	87	)	)	PUNCT
fnp-8974	338	88	,	,	PUNCT
fnp-8974	338	89	university	university	NOUN
fnp-8974	338	90	hospital	hospital	NOUN
fnp-8974	338	91	frankfurt	frankfurt	PROPN
fnp-8974	338	92	,	,	PUNCT
fnp-8974	338	93	goethe	goethe	PROPN
fnp-8974	338	94	university	university	PROPN
fnp-8974	338	95	,	,	PUNCT
fnp-8974	338	96	frankfurt	frankfurt	PROPN
fnp-8974	338	97	am	be	AUX
fnp-8974	338	98	main	main	ADJ
fnp-8974	338	99	,	,	PUNCT
fnp-8974	338	100	germany	germany	NOUN
fnp-8974	338	101	2	2	NUM
fnp-8974	338	102	german	german	ADJ
fnp-8974	338	103	cancer	cancer	NOUN
fnp-8974	338	104	consortium	consortium	NOUN
fnp-8974	338	105	(	(	PUNCT
fnp-8974	338	106	dktk	dktk	NOUN
fnp-8974	338	107	)	)	PUNCT
fnp-8974	338	108	,	,	PUNCT
fnp-8974	338	109	partner	partner	NOUN
fnp-8974	338	110	site	site	NOUN
fnp-8974	338	111	frankfurt	frankfurt	PROPN
fnp-8974	338	112	am	be	AUX
fnp-8974	338	113	mainz	mainz	ADJ
fnp-8974	338	114	,	,	PUNCT
fnp-8974	338	115	german	german	ADJ
fnp-8974	338	116	cancer	cancer	NOUN
fnp-8974	338	117	research	research	NOUN
fnp-8974	338	118	center	center	NOUN
fnp-8974	338	119	(	(	PUNCT
fnp-8974	338	120	dkfz	dkfz	PROPN
fnp-8974	338	121	)	)	PUNCT
fnp-8974	338	122	,	,	PUNCT
fnp-8974	338	123	heidelberg	heidelberg	PROPN
fnp-8974	338	124	,	,	PUNCT
fnp-8974	338	125	germany	germany	PROPN
fnp-8974	338	126	3	3	NUM
fnp-8974	338	127	department	department	PROPN
fnp-8974	338	128	of	of	ADP
fnp-8974	338	129	neuropathology	neuropathology	NOUN
fnp-8974	338	130	,	,	PUNCT
fnp-8974	338	131	university	university	NOUN
fnp-8974	338	132	hospital	hospital	NOUN
fnp-8974	338	133	heidelberg	heidelberg	PROPN
fnp-8974	338	134	,	,	PUNCT
fnp-8974	338	135	heidelberg	heidelberg	PROPN
fnp-8974	338	136	,	,	PUNCT
fnp-8974	338	137	germany	germany	PROPN
fnp-8974	338	138	4	4	NUM
fnp-8974	338	139	department	department	NOUN
fnp-8974	338	140	of	of	ADP
fnp-8974	338	141	neuropathology	neuropathology	NOUN
fnp-8974	338	142	,	,	PUNCT
fnp-8974	338	143	charité	charité	PROPN
fnp-8974	338	144	-	-	PUNCT
fnp-8974	338	145	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	338	146	berlin	berlin	PROPN
fnp-8974	338	147	,	,	PUNCT
fnp-8974	338	148	berlin	berlin	PROPN
fnp-8974	338	149	,	,	PUNCT
fnp-8974	338	150	germany	germany	PROPN
fnp-8974	338	151	5	5	NUM
fnp-8974	338	152	dr	dr	PROPN
fnp-8974	338	153	.	.	PROPN
fnp-8974	338	154	senckenberg	senckenberg	PROPN
fnp-8974	338	155	institute	institute	PROPN
fnp-8974	338	156	of	of	ADP
fnp-8974	338	157	neurooncology	neurooncology	PROPN
fnp-8974	338	158	,	,	PUNCT
fnp-8974	338	159	university	university	NOUN
fnp-8974	338	160	hospital	hospital	NOUN
fnp-8974	338	161	frankfurt	frankfurt	PROPN
fnp-8974	338	162	,	,	PUNCT
fnp-8974	338	163	goethe	goethe	PROPN
fnp-8974	338	164	university	university	PROPN
fnp-8974	338	165	,	,	PUNCT
fnp-8974	338	166	frankfurt	frankfurt	PROPN
fnp-8974	338	167	am	be	AUX
fnp-8974	338	168	main	main	ADJ
fnp-8974	338	169	,	,	PUNCT
fnp-8974	338	170	germany	germany	PROPN
fnp-8974	338	171	6	6	NUM
fnp-8974	338	172	laboratory	laboratory	NOUN
fnp-8974	338	173	of	of	ADP
fnp-8974	338	174	pathology	pathology	NOUN
fnp-8974	338	175	,	,	PUNCT
fnp-8974	338	176	center	center	NOUN
fnp-8974	338	177	for	for	ADP
fnp-8974	338	178	cancer	cancer	NOUN
fnp-8974	338	179	research	research	NOUN
fnp-8974	338	180	,	,	PUNCT
fnp-8974	338	181	national	national	PROPN
fnp-8974	338	182	cancer	cancer	PROPN
fnp-8974	338	183	institute	institute	PROPN
fnp-8974	338	184	,	,	PUNCT
fnp-8974	338	185	national	national	PROPN
fnp-8974	338	186	institutes	institutes	PROPN
fnp-8974	338	187	of	of	ADP
fnp-8974	338	188	health	health	NOUN
fnp-8974	338	189	,	,	PUNCT
fnp-8974	338	190	bethesda	bethesda	NOUN
fnp-8974	338	191	,	,	PUNCT
fnp-8974	338	192	maryland	maryland	PROPN
fnp-8974	338	193	,	,	PUNCT
fnp-8974	338	194	united	united	PROPN
fnp-8974	338	195	states	states	PROPN
fnp-8974	338	196	7	7	NUM
fnp-8974	338	197	division	division	NOUN
fnp-8974	338	198	of	of	ADP
fnp-8974	338	199	artificial	artificial	ADJ
fnp-8974	338	200	intelligence	intelligence	NOUN
fnp-8974	338	201	in	in	ADP
fnp-8974	338	202	oncology	oncology	NOUN
fnp-8974	338	203	,	,	PUNCT
fnp-8974	338	204	german	german	ADJ
fnp-8974	338	205	cancer	cancer	NOUN
fnp-8974	338	206	research	research	NOUN
fnp-8974	338	207	center	center	NOUN
fnp-8974	338	208	,	,	PUNCT
fnp-8974	338	209	heidelberg	heidelberg	PROPN
fnp-8974	338	210	,	,	PUNCT
fnp-8974	338	211	germany	germany	PROPN
fnp-8974	338	212	dna	dna	PROPN
fnp-8974	338	213	methylation	methylation	NOUN
fnp-8974	338	214	profiling	profiling	NOUN
fnp-8974	338	215	has	have	AUX
fnp-8974	338	216	become	become	VERB
fnp-8974	338	217	an	an	DET
fnp-8974	338	218	important	important	ADJ
fnp-8974	338	219	tool	tool	NOUN
fnp-8974	338	220	in	in	ADP
fnp-8974	338	221	neuropathological	neuropathological	ADJ
fnp-8974	338	222	diagnostics	diagnostic	NOUN
fnp-8974	338	223	,	,	PUNCT
fnp-8974	338	224	often	often	ADV
fnp-8974	338	225	enabling	enable	VERB
fnp-8974	338	226	precise	precise	ADJ
fnp-8974	338	227	who	who	PRON
fnp-8974	338	228	classification	classification	NOUN
fnp-8974	338	229	of	of	ADP
fnp-8974	338	230	cns	cns	NOUN
fnp-8974	338	231	tumors	tumor	NOUN
fnp-8974	338	232	.	.	PUNCT
fnp-8974	339	1	however	however	ADV
fnp-8974	339	2	,	,	PUNCT
fnp-8974	339	3	a	a	DET
fnp-8974	339	4	subset	subset	NOUN
fnp-8974	339	5	of	of	ADP
fnp-8974	339	6	cases	case	NOUN
fnp-8974	339	7	remains	remain	VERB
fnp-8974	339	8	unclassifiable	unclassifiable	ADJ
fnp-8974	339	9	using	use	VERB
fnp-8974	339	10	current	current	ADJ
fnp-8974	339	11	methylation	methylation	NOUN
fnp-8974	339	12	-	-	PUNCT
fnp-8974	339	13	based	base	VERB
fnp-8974	339	14	brain	brain	NOUN
fnp-8974	339	15	tumor	tumor	NOUN
fnp-8974	339	16	classifiers	classifier	NOUN
fnp-8974	339	17	.	.	PUNCT
fnp-8974	340	1	we	we	PRON
fnp-8974	340	2	retrospectively	retrospectively	ADV
fnp-8974	340	3	analyzed	analyze	VERB
fnp-8974	340	4	a	a	DET
fnp-8974	340	5	cohort	cohort	NOUN
fnp-8974	340	6	of	of	ADP
fnp-8974	340	7	1,853	1,853	NUM
fnp-8974	340	8	cns	cns	NOUN
fnp-8974	340	9	tissue	tissue	NOUN
fnp-8974	340	10	samples	sample	NOUN
fnp-8974	340	11	diagnosed	diagnose	VERB
fnp-8974	340	12	between	between	ADP
fnp-8974	340	13	2017	2017	NUM
fnp-8974	340	14	and	and	CCONJ
fnp-8974	340	15	2024	2024	NUM
fnp-8974	340	16	using	use	VERB
fnp-8974	340	17	genome	genome	NOUN
fnp-8974	340	18	-	-	PUNCT
fnp-8974	340	19	wide	wide	ADJ
fnp-8974	340	20	dna	dna	NOUN
fnp-8974	340	21	methylation	methylation	NOUN
fnp-8974	340	22	profiling	profiling	NOUN
fnp-8974	340	23	and	and	CCONJ
fnp-8974	340	24	identified	identify	VERB
fnp-8974	340	25	a	a	DET
fnp-8974	340	26	cohort	cohort	NOUN
fnp-8974	340	27	of	of	ADP
fnp-8974	340	28	393	393	NUM
fnp-8974	340	29	cases	case	NOUN
fnp-8974	340	30	(	(	PUNCT
fnp-8974	340	31	21	21	NUM
fnp-8974	340	32	 	 	SPACE
fnp-8974	340	33	%	%	NOUN
fnp-8974	340	34	)	)	PUNCT
fnp-8974	340	35	unclassifiable	unclassifiable	ADJ
fnp-8974	340	36	by	by	ADP
fnp-8974	340	37	the	the	DET
fnp-8974	340	38	heidelberg	heidelberg	PROPN
fnp-8974	340	39	brain	brain	NOUN
fnp-8974	340	40	tumor	tumor	NOUN
fnp-8974	340	41	classifier	classifier	NOUN
fnp-8974	340	42	v12.8e	v12.8e	PROPN
fnp-8974	340	43	.	.	PUNCT
fnp-8974	341	1	for	for	ADP
fnp-8974	341	2	a	a	DET
fnp-8974	341	3	representative	representative	ADJ
fnp-8974	341	4	subset	subset	NOUN
fnp-8974	341	5	of	of	ADP
fnp-8974	341	6	252	252	NUM
fnp-8974	341	7	cases	case	NOUN
fnp-8974	341	8	,	,	PUNCT
fnp-8974	341	9	we	we	PRON
fnp-8974	341	10	compared	compare	VERB
fnp-8974	341	11	the	the	DET
fnp-8974	341	12	classification	classification	NOUN
fnp-8974	341	13	results	result	NOUN
fnp-8974	341	14	of	of	ADP
fnp-8974	341	15	the	the	DET
fnp-8974	341	16	bethesda	bethesda	NOUN
fnp-8974	341	17	classifier	classifier	PROPN
fnp-8974	341	18	v3	v3	PROPN
fnp-8974	341	19	(	(	PUNCT
fnp-8974	341	20	bv3	bv3	ADV
fnp-8974	341	21	)	)	PUNCT
fnp-8974	341	22	and	and	CCONJ
fnp-8974	341	23	hetairos	hetairo	NOUN
fnp-8974	341	24	,	,	PUNCT
fnp-8974	341	25	a	a	DET
fnp-8974	341	26	novel	novel	NOUN
fnp-8974	341	27	classifier	classifier	NOUN
fnp-8974	341	28	predicting	predict	VERB
fnp-8974	341	29	methylation	methylation	NOUN
fnp-8974	341	30	classes	class	NOUN
fnp-8974	341	31	from	from	ADP
fnp-8974	341	32	digital	digital	ADJ
fnp-8974	341	33	h&e	h&e	PROPN
fnp-8974	341	34	-	-	PUNCT
fnp-8974	341	35	stained	stain	VERB
fnp-8974	341	36	slides	slide	NOUN
fnp-8974	341	37	,	,	PUNCT
fnp-8974	341	38	and	and	CCONJ
fnp-8974	341	39	examined	examine	VERB
fnp-8974	341	40	preanalytic	preanalytic	ADJ
fnp-8974	341	41	,	,	PUNCT
fnp-8974	341	42	histological	histological	ADJ
fnp-8974	341	43	,	,	PUNCT
fnp-8974	341	44	and	and	CCONJ
fnp-8974	341	45	molecular	molecular	ADJ
fnp-8974	341	46	features	feature	NOUN
fnp-8974	341	47	.	.	PUNCT
fnp-8974	342	1	among	among	ADP
fnp-8974	342	2	252	252	NUM
fnp-8974	342	3	cases	case	NOUN
fnp-8974	342	4	that	that	PRON
fnp-8974	342	5	were	be	AUX
fnp-8974	342	6	unclassifiable	unclassifiable	ADJ
fnp-8974	342	7	by	by	ADP
fnp-8974	342	8	v12.8e	v12.8e	PROPN
fnp-8974	342	9	,	,	PUNCT
fnp-8974	342	10	107/252	107/252	PROPN
fnp-8974	342	11	cases	case	NOUN
fnp-8974	342	12	(	(	PUNCT
fnp-8974	342	13	42	42	NUM
fnp-8974	342	14	 	 	SPACE
fnp-8974	342	15	%	%	NOUN
fnp-8974	342	16	)	)	PUNCT
fnp-8974	342	17	were	be	AUX
fnp-8974	342	18	correctly	correctly	ADV
fnp-8974	342	19	classified	classified	ADJ
fnp-8974	342	20	using	use	VERB
fnp-8974	342	21	the	the	DET
fnp-8974	342	22	bv3	bv3	ADJ
fnp-8974	342	23	(	(	PUNCT
fnp-8974	342	24	unclassifiable	unclassifiable	ADJ
fnp-8974	342	25	cases	case	NOUN
fnp-8974	342	26	:	:	PUNCT
fnp-8974	342	27	118/252	118/252	NUM
fnp-8974	342	28	47	47	NUM
fnp-8974	342	29	 	 	SPACE
fnp-8974	342	30	%	%	NOUN
fnp-8974	342	31	;	;	PUNCT
fnp-8974	342	32	alternative	alternative	ADJ
fnp-8974	342	33	diagnostic	diagnostic	ADJ
fnp-8974	342	34	suggestion	suggestion	NOUN
fnp-8974	342	35	:	:	PUNCT
fnp-8974	342	36	in	in	ADP
fnp-8974	342	37	27/252	27/252	NUM
fnp-8974	342	38	cases	case	NOUN
fnp-8974	342	39	11	11	NUM
fnp-8974	342	40	 	 	SPACE
fnp-8974	342	41	%	%	NOUN
fnp-8974	342	42	)	)	PUNCT
fnp-8974	342	43	.	.	PUNCT
fnp-8974	343	1	93/252	93/252	NUM
fnp-8974	343	2	cases	case	NOUN
fnp-8974	343	3	(	(	PUNCT
fnp-8974	343	4	37	37	NUM
fnp-8974	343	5	 	 	SPACE
fnp-8974	343	6	%	%	NOUN
fnp-8974	343	7	)	)	PUNCT
fnp-8974	343	8	were	be	AUX
fnp-8974	343	9	correctly	correctly	ADV
fnp-8974	343	10	classified	classify	VERB
fnp-8974	343	11	by	by	ADP
fnp-8974	343	12	hetairos	hetairo	NOUN
fnp-8974	343	13	(	(	PUNCT
fnp-8974	343	14	unclassifiable	unclassifiable	ADJ
fnp-8974	343	15	cases	case	NOUN
fnp-8974	343	16	:	:	PUNCT
fnp-8974	343	17	145/252	145/252	NUM
fnp-8974	343	18	58	58	NUM
fnp-8974	343	19	 	 	SPACE
fnp-8974	343	20	%	%	NOUN
fnp-8974	343	21	;	;	PUNCT
fnp-8974	343	22	alternative	alternative	ADJ
fnp-8974	343	23	diagnostic	diagnostic	ADJ
fnp-8974	343	24	suggestion	suggestion	NOUN
fnp-8974	343	25	:	:	PUNCT
fnp-8974	343	26	in	in	ADP
fnp-8974	343	27	14/252	14/252	NUM
fnp-8974	343	28	cases	case	NOUN
fnp-8974	343	29	6	6	NUM
fnp-8974	343	30	 	 	SPACE
fnp-8974	343	31	%	%	NOUN
fnp-8974	343	32	)	)	PUNCT
fnp-8974	343	33	.	.	PUNCT
fnp-8974	344	1	the	the	DET
fnp-8974	344	2	bv3	bv3	ADV
fnp-8974	344	3	correctly	correctly	ADV
fnp-8974	344	4	identified	identify	VERB
fnp-8974	344	5	74/112	74/112	NUM
fnp-8974	344	6	glioblastomas	glioblastoma	NOUN
fnp-8974	344	7	,	,	PUNCT
fnp-8974	344	8	idh	idh	NOUN
fnp-8974	344	9	-	-	PUNCT
fnp-8974	344	10	wildtype	wildtype	NOUN
fnp-8974	344	11	(	(	PUNCT
fnp-8974	344	12	gbm	gbm	NOUN
fnp-8974	344	13	;	;	PUNCT
fnp-8974	344	14	66	66	NUM
fnp-8974	344	15	 	 	SPACE
fnp-8974	344	16	%	%	NOUN
fnp-8974	344	17	)	)	PUNCT
fnp-8974	344	18	,	,	PUNCT
fnp-8974	344	19	including	include	VERB
fnp-8974	344	20	76	76	NUM
fnp-8974	344	21	 	 	SPACE
fnp-8974	344	22	%	%	NOUN
fnp-8974	344	23	histological	histological	ADJ
fnp-8974	344	24	(	(	PUNCT
fnp-8974	344	25	61/80	61/80	NUM
fnp-8974	344	26	)	)	PUNCT
fnp-8974	344	27	and	and	CCONJ
fnp-8974	344	28	41	41	NUM
fnp-8974	344	29	 	 	SPACE
fnp-8974	344	30	%	%	NOUN
fnp-8974	344	31	molecular	molecular	ADJ
fnp-8974	344	32	(	(	PUNCT
fnp-8974	344	33	13/32	13/32	NUM
fnp-8974	344	34	)	)	PUNCT
fnp-8974	344	35	gbm	gbm	NOUN
fnp-8974	344	36	.	.	PUNCT
fnp-8974	345	1	hetairos	hetairo	NOUN
fnp-8974	345	2	identified	identify	VERB
fnp-8974	345	3	78/112	78/112	NUM
fnp-8974	345	4	gbm	gbm	NOUN
fnp-8974	345	5	(	(	PUNCT
fnp-8974	345	6	70	70	NUM
fnp-8974	345	7	 	 	SPACE
fnp-8974	345	8	%	%	NOUN
fnp-8974	345	9	)	)	PUNCT
fnp-8974	345	10	,	,	PUNCT
fnp-8974	345	11	including	include	VERB
fnp-8974	345	12	75	75	NUM
fnp-8974	345	13	 	 	SPACE
fnp-8974	345	14	%	%	NOUN
fnp-8974	345	15	of	of	ADP
fnp-8974	345	16	the	the	DET
fnp-8974	345	17	histological	histological	ADJ
fnp-8974	345	18	(	(	PUNCT
fnp-8974	345	19	60/80	60/80	NUM
fnp-8974	345	20	)	)	PUNCT
fnp-8974	345	21	and	and	CCONJ
fnp-8974	345	22	56	56	NUM
fnp-8974	345	23	 	 	SPACE
fnp-8974	345	24	%	%	NOUN
fnp-8974	345	25	of	of	ADP
fnp-8974	345	26	the	the	DET
fnp-8974	345	27	molecular	molecular	ADJ
fnp-8974	345	28	gbm	gbm	NOUN
fnp-8974	345	29	(	(	PUNCT
fnp-8974	345	30	18/32	18/32	NUM
fnp-8974	345	31	)	)	PUNCT
fnp-8974	345	32	.	.	PUNCT
fnp-8974	346	1	in	in	ADP
fnp-8974	346	2	both	both	DET
fnp-8974	346	3	cases	case	NOUN
fnp-8974	346	4	,	,	PUNCT
fnp-8974	346	5	the	the	DET
fnp-8974	346	6	rf_purify	rf_purify	VERB
fnp-8974	346	7	-	-	PUNCT
fnp-8974	346	8	estimated	estimate	VERB
fnp-8974	346	9	tumor	tumor	NOUN
fnp-8974	346	10	cell	cell	NOUN
fnp-8974	346	11	content	content	NOUN
fnp-8974	346	12	of	of	ADP
fnp-8974	346	13	correctly	correctly	ADV
fnp-8974	346	14	classified	classified	ADJ
fnp-8974	346	15	gbm	gbm	NOUN
fnp-8974	346	16	samples	sample	NOUN
fnp-8974	346	17	was	be	AUX
fnp-8974	346	18	significantly	significantly	ADV
fnp-8974	346	19	lower	low	ADJ
fnp-8974	346	20	compared	compare	VERB
fnp-8974	346	21	to	to	ADP
fnp-8974	346	22	458	458	NUM
fnp-8974	346	23	gbm	gbm	NOUN
fnp-8974	346	24	cases	case	NOUN
fnp-8974	346	25	correctly	correctly	ADV
fnp-8974	346	26	classified	classify	VERB
fnp-8974	346	27	by	by	ADP
fnp-8974	346	28	v12.8e	v12.8e	PROPN
fnp-8974	346	29	(	(	PUNCT
fnp-8974	346	30	p	p	X
fnp-8974	346	31	 	 	SPACE
fnp-8974	346	32	=	=	NOUN
fnp-8974	346	33	 	 	SPACE
fnp-8974	346	34	0.01086	0.01086	NUM
fnp-8974	346	35	and	and	CCONJ
fnp-8974	346	36	p	p	X
fnp-8974	346	37	 	 	SPACE
fnp-8974	346	38	=	=	NOUN
fnp-8974	346	39	 	 	SPACE
fnp-8974	346	40	0.01966	0.01966	NUM
fnp-8974	346	41	,	,	PUNCT
fnp-8974	346	42	respectively	respectively	ADV
fnp-8974	346	43	)	)	PUNCT
fnp-8974	346	44	.	.	PUNCT
fnp-8974	347	1	these	these	DET
fnp-8974	347	2	results	result	NOUN
fnp-8974	347	3	highlight	highlight	VERB
fnp-8974	347	4	the	the	DET
fnp-8974	347	5	complementary	complementary	ADJ
fnp-8974	347	6	value	value	NOUN
fnp-8974	347	7	of	of	ADP
fnp-8974	347	8	bv3	bv3	NOUN
fnp-8974	347	9	and	and	CCONJ
fnp-8974	347	10	hetairos	hetairo	NOUN
fnp-8974	347	11	in	in	ADP
fnp-8974	347	12	reliably	reliably	ADV
fnp-8974	347	13	classifying	classify	VERB
fnp-8974	347	14	diagnostically	diagnostically	ADV
fnp-8974	347	15	challenging	challenging	ADJ
fnp-8974	347	16	cases	case	NOUN
fnp-8974	347	17	,	,	PUNCT
fnp-8974	347	18	especially	especially	ADV
fnp-8974	347	19	in	in	ADP
fnp-8974	347	20	samples	sample	NOUN
fnp-8974	347	21	with	with	ADP
fnp-8974	347	22	low	low	ADJ
fnp-8974	347	23	tumor	tumor	NOUN
fnp-8974	347	24	cell	cell	NOUN
fnp-8974	347	25	content	content	NOUN
fnp-8974	347	26	.	.	PUNCT
fnp-8974	348	1	p27	p27	PROPN
fnp-8974	348	2	free	free	ADJ
fnp-8974	348	3	neuropathol	neuropathol	NOUN
fnp-8974	348	4	6:17:42	6:17:42	NUM
fnp-8974	348	5	immunothrombosis	immunothrombosis	NOUN
fnp-8974	348	6	and	and	CCONJ
fnp-8974	348	7	endothelial	endothelial	ADJ
fnp-8974	348	8	priming	priming	NOUN
fnp-8974	348	9	in	in	ADP
fnp-8974	348	10	early	early	ADJ
fnp-8974	348	11	brain	brain	NOUN
fnp-8974	348	12	metastasis	metastasis	NOUN
fnp-8974	348	13	katharina	katharina	PROPN
fnp-8974	348	14	müller1	müller1	PROPN
fnp-8974	348	15	,	,	PUNCT
fnp-8974	348	16	willy	willy	PROPN
fnp-8974	348	17	hube2	hube2	PROPN
fnp-8974	348	18	,	,	PUNCT
fnp-8974	348	19	ferdinand	ferdinand	PROPN
fnp-8974	348	20	schallerer3	schallerer3	PROPN
fnp-8974	348	21	,	,	PUNCT
fnp-8974	348	22	linda	linda	PROPN
fnp-8974	348	23	bergmayr4	bergmayr4	PROPN
fnp-8974	348	24	,	,	PUNCT
fnp-8974	348	25	robert	robert	PROPN
fnp-8974	348	26	piecyk5	piecyk5	PROPN
fnp-8974	348	27	,	,	PUNCT
fnp-8974	348	28	thomas	thomas	PROPN
fnp-8974	348	29	eska2	eska2	PROPN
fnp-8974	348	30	,	,	PUNCT
fnp-8974	348	31	edis	edis	PROPN
fnp-8974	348	32	jardim3	jardim3	PROPN
fnp-8974	348	33	,	,	PUNCT
fnp-8974	348	34	elene	elene	PROPN
fnp-8974	348	35	nicolaishvili3	nicolaishvili3	PROPN
fnp-8974	348	36	,	,	PUNCT
fnp-8974	348	37	lisa	lisa	PROPN
fnp-8974	348	38	sevenich6	sevenich6	PROPN
fnp-8974	348	39	,	,	PUNCT
fnp-8974	348	40	kristian	kristian	PROPN
fnp-8974	348	41	unger5	unger5	PROPN
fnp-8974	348	42	,	,	PUNCT
fnp-8974	348	43	philipp	philipp	PROPN
fnp-8974	348	44	jurmeister4	jurmeister4	PROPN
fnp-8974	348	45	,	,	PUNCT
fnp-8974	348	46	louisa	louisa	PROPN
fnp-8974	348	47	von	von	PROPN
fnp-8974	348	48	baumgarten3	baumgarten3	PROPN
fnp-8974	348	49	,	,	PUNCT
fnp-8974	348	50	patrick	patrick	PROPN
fnp-8974	348	51	n.	n.	PROPN
fnp-8974	348	52	harter2	harter2	PROPN
fnp-8974	348	53	1	1	NUM
fnp-8974	348	54	department	department	NOUN
fnp-8974	348	55	of	of	ADP
fnp-8974	348	56	neurology	neurology	NOUN
fnp-8974	348	57	,	,	PUNCT
fnp-8974	348	58	university	university	NOUN
fnp-8974	348	59	hospital	hospital	NOUN
fnp-8974	348	60	,	,	PUNCT
fnp-8974	348	61	ludwig	ludwig	PROPN
fnp-8974	348	62	-	-	PUNCT
fnp-8974	348	63	maximilians	maximilians	PROPN
fnp-8974	348	64	-	-	PUNCT
fnp-8974	348	65	university	university	NOUN
fnp-8974	348	66	munich	munich	PROPN
fnp-8974	348	67	,	,	PUNCT
fnp-8974	348	68	munich	munich	PROPN
fnp-8974	348	69	,	,	PUNCT
fnp-8974	348	70	germany	germany	PROPN
fnp-8974	348	71	2	2	NUM
fnp-8974	348	72	center	center	NOUN
fnp-8974	348	73	for	for	ADP
fnp-8974	348	74	neuropathology	neuropathology	NOUN
fnp-8974	348	75	and	and	CCONJ
fnp-8974	348	76	prion	prion	NOUN
fnp-8974	348	77	research	research	NOUN
fnp-8974	348	78	,	,	PUNCT
fnp-8974	348	79	faculty	faculty	NOUN
fnp-8974	348	80	of	of	ADP
fnp-8974	348	81	medicine	medicine	NOUN
fnp-8974	348	82	,	,	PUNCT
fnp-8974	348	83	ludwig	ludwig	PROPN
fnp-8974	348	84	-	-	PUNCT
fnp-8974	348	85	maximilians	maximilians	PROPN
fnp-8974	348	86	-	-	PUNCT
fnp-8974	348	87	university	university	NOUN
fnp-8974	348	88	munich	munich	PROPN
fnp-8974	348	89	,	,	PUNCT
fnp-8974	348	90	munich	munich	PROPN
fnp-8974	348	91	,	,	PUNCT
fnp-8974	348	92	germany	germany	PROPN
fnp-8974	348	93	3	3	NUM
fnp-8974	348	94	department	department	NOUN
fnp-8974	348	95	of	of	ADP
fnp-8974	348	96	neurosurgery	neurosurgery	NOUN
fnp-8974	348	97	,	,	PUNCT
fnp-8974	348	98	university	university	NOUN
fnp-8974	348	99	hospital	hospital	NOUN
fnp-8974	348	100	,	,	PUNCT
fnp-8974	348	101	ludwig	ludwig	PROPN
fnp-8974	348	102	-	-	PUNCT
fnp-8974	348	103	maximilians	maximilians	PROPN
fnp-8974	348	104	-	-	PUNCT
fnp-8974	348	105	university	university	NOUN
fnp-8974	348	106	munich	munich	PROPN
fnp-8974	348	107	,	,	PUNCT
fnp-8974	348	108	munich	munich	PROPN
fnp-8974	348	109	,	,	PUNCT
fnp-8974	348	110	germany	germany	PROPN
fnp-8974	348	111	4	4	NUM
fnp-8974	348	112	department	department	PROPN
fnp-8974	348	113	of	of	ADP
fnp-8974	348	114	pathology	pathology	PROPN
fnp-8974	348	115	,	,	PUNCT
fnp-8974	348	116	faculty	faculty	NOUN
fnp-8974	348	117	of	of	ADP
fnp-8974	348	118	medicine	medicine	NOUN
fnp-8974	348	119	,	,	PUNCT
fnp-8974	348	120	ludwig	ludwig	PROPN
fnp-8974	348	121	-	-	PUNCT
fnp-8974	348	122	maximilians	maximilians	PROPN
fnp-8974	348	123	-	-	PUNCT
fnp-8974	348	124	university	university	NOUN
fnp-8974	348	125	munich	munich	PROPN
fnp-8974	348	126	,	,	PUNCT
fnp-8974	348	127	munich	munich	PROPN
fnp-8974	348	128	,	,	PUNCT
fnp-8974	348	129	germany	germany	PROPN
fnp-8974	348	130	5	5	NUM
fnp-8974	348	131	department	department	NOUN
fnp-8974	348	132	of	of	ADP
fnp-8974	348	133	radiation	radiation	NOUN
fnp-8974	348	134	oncology	oncology	NOUN
fnp-8974	348	135	,	,	PUNCT
fnp-8974	348	136	university	university	NOUN
fnp-8974	348	137	hospital	hospital	NOUN
fnp-8974	348	138	,	,	PUNCT
fnp-8974	348	139	ludwig	ludwig	PROPN
fnp-8974	348	140	-	-	PUNCT
fnp-8974	348	141	maximilians	maximilians	PROPN
fnp-8974	348	142	-	-	PUNCT
fnp-8974	348	143	university	university	NOUN
fnp-8974	348	144	munich	munich	PROPN
fnp-8974	348	145	,	,	PUNCT
fnp-8974	348	146	munich	munich	PROPN
fnp-8974	348	147	,	,	PUNCT
fnp-8974	348	148	germany	germany	PROPN
fnp-8974	348	149	6	6	NUM
fnp-8974	348	150	university	university	NOUN
fnp-8974	348	151	of	of	ADP
fnp-8974	348	152	tübingen	tübingen	PROPN
fnp-8974	348	153	m3	m3	PROPN
fnp-8974	348	154	institute	institute	PROPN
fnp-8974	348	155	,	,	PUNCT
fnp-8974	348	156	tübingen	tübingen	PROPN
fnp-8974	348	157	,	,	PUNCT
fnp-8974	348	158	germany	germany	PROPN
fnp-8974	348	159	background	background	NOUN
fnp-8974	348	160	:	:	PUNCT
fnp-8974	348	161	the	the	DET
fnp-8974	348	162	incidence	incidence	NOUN
fnp-8974	348	163	of	of	ADP
fnp-8974	348	164	brain	brain	NOUN
fnp-8974	348	165	metastases	metastasis	NOUN
fnp-8974	348	166	is	be	AUX
fnp-8974	348	167	rising	rise	VERB
fnp-8974	348	168	among	among	ADP
fnp-8974	348	169	patients	patient	NOUN
fnp-8974	348	170	with	with	ADP
fnp-8974	348	171	systemic	systemic	ADJ
fnp-8974	348	172	malignancies	malignancy	NOUN
fnp-8974	348	173	,	,	PUNCT
fnp-8974	348	174	yet	yet	CCONJ
fnp-8974	348	175	preventive	preventive	ADJ
fnp-8974	348	176	strategies	strategy	NOUN
fnp-8974	348	177	targeting	target	VERB
fnp-8974	348	178	the	the	DET
fnp-8974	348	179	earliest	early	ADJ
fnp-8974	348	180	phases	phase	NOUN
fnp-8974	348	181	of	of	ADP
fnp-8974	348	182	metastatic	metastatic	ADJ
fnp-8974	348	183	seeding	seeding	NOUN
fnp-8974	348	184	into	into	ADP
fnp-8974	348	185	the	the	DET
fnp-8974	348	186	cns	cns	NOUN
fnp-8974	348	187	remain	remain	VERB
fnp-8974	348	188	lacking	lack	VERB
fnp-8974	348	189	.	.	PUNCT
fnp-8974	349	1	emerging	emerge	VERB
fnp-8974	349	2	evidence	evidence	NOUN
fnp-8974	349	3	points	point	VERB
fnp-8974	349	4	to	to	ADP
fnp-8974	349	5	the	the	DET
fnp-8974	349	6	critical	critical	ADJ
fnp-8974	349	7	role	role	NOUN
fnp-8974	349	8	of	of	ADP
fnp-8974	349	9	vascular	vascular	ADJ
fnp-8974	349	10	and	and	CCONJ
fnp-8974	349	11	thromboinflammatory	thromboinflammatory	ADJ
fnp-8974	349	12	responses	response	NOUN
fnp-8974	349	13	during	during	ADP
fnp-8974	349	14	the	the	DET
fnp-8974	349	15	initial	initial	ADJ
fnp-8974	349	16	arrest	arrest	NOUN
fnp-8974	349	17	of	of	ADP
fnp-8974	349	18	circulating	circulate	VERB
fnp-8974	349	19	tumor	tumor	NOUN
fnp-8974	349	20	cells	cell	NOUN
fnp-8974	349	21	in	in	ADP
fnp-8974	349	22	the	the	DET
fnp-8974	349	23	brain	brain	NOUN
fnp-8974	349	24	microvasculature	microvasculature	NOUN
fnp-8974	349	25	—	—	PUNCT
fnp-8974	349	26	a	a	DET
fnp-8974	349	27	process	process	NOUN
fnp-8974	349	28	that	that	PRON
fnp-8974	349	29	mirrors	mirror	VERB
fnp-8974	349	30	key	key	ADJ
fnp-8974	349	31	aspects	aspect	NOUN
fnp-8974	349	32	of	of	ADP
fnp-8974	349	33	ischemic	ischemic	ADJ
fnp-8974	349	34	stroke	stroke	NOUN
fnp-8974	349	35	.	.	PUNCT
fnp-8974	350	1	methods	method	NOUN
fnp-8974	350	2	:	:	PUNCT
fnp-8974	350	3	using	use	VERB
fnp-8974	350	4	syngeneic	syngeneic	NOUN
fnp-8974	350	5	mouse	mouse	NOUN
fnp-8974	350	6	models	model	NOUN
fnp-8974	350	7	,	,	PUNCT
fnp-8974	350	8	we	we	PRON
fnp-8974	350	9	injected	inject	VERB
fnp-8974	350	10	tumor	tumor	NOUN
fnp-8974	350	11	cells	cell	NOUN
fnp-8974	350	12	into	into	ADP
fnp-8974	350	13	the	the	DET
fnp-8974	350	14	internal	internal	ADJ
fnp-8974	350	15	carotid	carotid	NOUN
fnp-8974	350	16	artery	artery	NOUN
fnp-8974	350	17	to	to	PART
fnp-8974	350	18	induce	induce	VERB
fnp-8974	350	19	brain	brain	NOUN
fnp-8974	350	20	metastases	metastasis	NOUN
fnp-8974	350	21	and	and	CCONJ
fnp-8974	350	22	analyzed	analyze	VERB
fnp-8974	350	23	early	early	ADJ
fnp-8974	350	24	host	host	NOUN
fnp-8974	350	25	responses	response	NOUN
fnp-8974	350	26	via	via	ADP
fnp-8974	350	27	high	high	ADJ
fnp-8974	350	28	-	-	PUNCT
fnp-8974	350	29	resolution	resolution	NOUN
fnp-8974	350	30	spatial	spatial	ADJ
fnp-8974	350	31	transcriptomics	transcriptomic	NOUN
fnp-8974	350	32	.	.	PUNCT
fnp-8974	351	1	transcriptional	transcriptional	ADJ
fnp-8974	351	2	profiling	profiling	NOUN
fnp-8974	351	3	was	be	AUX
fnp-8974	351	4	performed	perform	VERB
fnp-8974	351	5	at	at	ADP
fnp-8974	351	6	days	day	NOUN
fnp-8974	351	7	1	1	NUM
fnp-8974	351	8	and	and	CCONJ
fnp-8974	351	9	4	4	NUM
fnp-8974	351	10	post	post	NOUN
fnp-8974	351	11	-	-	NOUN
fnp-8974	351	12	injection	injection	NOUN
fnp-8974	351	13	,	,	PUNCT
fnp-8974	351	14	focusing	focus	VERB
fnp-8974	351	15	on	on	ADP
fnp-8974	351	16	the	the	DET
fnp-8974	351	17	perivascular	perivascular	ADJ
fnp-8974	351	18	microenvironment	microenvironment	NOUN
fnp-8974	351	19	surrounding	surround	VERB
fnp-8974	351	20	arrested	arrest	VERB
fnp-8974	351	21	ctcs	ctcs	NOUN
fnp-8974	351	22	.	.	PUNCT
fnp-8974	352	1	operating	operate	VERB
fnp-8974	352	2	under	under	ADP
fnp-8974	352	3	the	the	DET
fnp-8974	352	4	hypothesis	hypothesis	NOUN
fnp-8974	352	5	that	that	PRON
fnp-8974	352	6	early	early	ADJ
fnp-8974	352	7	thrombotic	thrombotic	ADJ
fnp-8974	352	8	events	event	NOUN
fnp-8974	352	9	are	be	AUX
fnp-8974	352	10	critical	critical	ADJ
fnp-8974	352	11	for	for	ADP
fnp-8974	352	12	brain	brain	NOUN
fnp-8974	352	13	metastasis	metastasis	NOUN
fnp-8974	352	14	seeding	seed	VERB
fnp-8974	352	15	,	,	PUNCT
fnp-8974	352	16	we	we	PRON
fnp-8974	352	17	investigated	investigate	VERB
fnp-8974	352	18	the	the	DET
fnp-8974	352	19	use	use	NOUN
fnp-8974	352	20	of	of	ADP
fnp-8974	352	21	rivaroxaban	rivaroxaban	NOUN
fnp-8974	352	22	as	as	ADP
fnp-8974	352	23	a	a	DET
fnp-8974	352	24	preventive	preventive	ADJ
fnp-8974	352	25	anticoagulant	anticoagulant	NOUN
fnp-8974	352	26	therapy	therapy	NOUN
fnp-8974	352	27	.	.	PUNCT
fnp-8974	353	1	results	result	NOUN
fnp-8974	353	2	:	:	PUNCT
fnp-8974	353	3	endothelial	endothelial	ADJ
fnp-8974	353	4	cells	cell	NOUN
fnp-8974	353	5	exhibited	exhibit	VERB
fnp-8974	353	6	the	the	DET
fnp-8974	353	7	most	most	ADV
fnp-8974	353	8	pronounced	pronounce	VERB
fnp-8974	353	9	early	early	ADJ
fnp-8974	353	10	transcriptional	transcriptional	ADJ
fnp-8974	353	11	response	response	NOUN
fnp-8974	353	12	,	,	PUNCT
fnp-8974	353	13	with	with	ADP
fnp-8974	353	14	upregulation	upregulation	NOUN
fnp-8974	353	15	of	of	ADP
fnp-8974	353	16	vascular	vascular	ADJ
fnp-8974	353	17	remodeling	remodeling	NOUN
fnp-8974	353	18	genes	gene	NOUN
fnp-8974	353	19	.	.	PUNCT
fnp-8974	354	1	this	this	DET
fnp-8974	354	2	gene	gene	NOUN
fnp-8974	354	3	expression	expression	NOUN
fnp-8974	354	4	was	be	AUX
fnp-8974	354	5	spatially	spatially	ADV
fnp-8974	354	6	restricted	restrict	VERB
fnp-8974	354	7	to	to	ADP
fnp-8974	354	8	areas	area	NOUN
fnp-8974	354	9	in	in	ADP
fnp-8974	354	10	direct	direct	ADJ
fnp-8974	354	11	proximity	proximity	NOUN
fnp-8974	354	12	to	to	ADP
fnp-8974	354	13	tumor	tumor	NOUN
fnp-8974	354	14	cells	cell	NOUN
fnp-8974	354	15	.	.	PUNCT
fnp-8974	355	1	glial	glial	ADJ
fnp-8974	355	2	cells	cell	NOUN
fnp-8974	355	3	near	near	ADP
fnp-8974	355	4	these	these	DET
fnp-8974	355	5	sites	site	NOUN
fnp-8974	355	6	expressed	express	VERB
fnp-8974	355	7	angiogenic	angiogenic	ADJ
fnp-8974	355	8	factors	factor	NOUN
fnp-8974	355	9	as	as	ADV
fnp-8974	355	10	well	well	ADV
fnp-8974	355	11	,	,	PUNCT
fnp-8974	355	12	indicating	indicate	VERB
fnp-8974	355	13	a	a	DET
fnp-8974	355	14	supportive	supportive	ADJ
fnp-8974	355	15	role	role	NOUN
fnp-8974	355	16	of	of	ADP
fnp-8974	355	17	the	the	DET
fnp-8974	355	18	glial	glial	ADJ
fnp-8974	355	19	compartment	compartment	NOUN
fnp-8974	355	20	in	in	ADP
fnp-8974	355	21	pre	pre	ADJ
fnp-8974	355	22	-	-	ADJ
fnp-8974	355	23	metastatic	metastatic	ADJ
fnp-8974	355	24	niche	niche	NOUN
fnp-8974	355	25	formation	formation	NOUN
fnp-8974	355	26	.	.	PUNCT
fnp-8974	356	1	notably	notably	ADV
fnp-8974	356	2	,	,	PUNCT
fnp-8974	356	3	we	we	PRON
fnp-8974	356	4	observed	observe	VERB
fnp-8974	356	5	lymphocyte	lymphocyte	ADJ
fnp-8974	356	6	-	-	PUNCT
fnp-8974	356	7	rich	rich	ADJ
fnp-8974	356	8	thrombi	thrombi	NOUN
fnp-8974	356	9	containing	contain	VERB
fnp-8974	356	10	intravascular	intravascular	ADJ
fnp-8974	356	11	tumor	tumor	NOUN
fnp-8974	356	12	cells	cell	NOUN
fnp-8974	356	13	.	.	PUNCT
fnp-8974	357	1	treatment	treatment	NOUN
fnp-8974	357	2	with	with	ADP
fnp-8974	357	3	the	the	DET
fnp-8974	357	4	anticoagulant	anticoagulant	ADJ
fnp-8974	357	5	rivaroxaban	rivaroxaban	NOUN
fnp-8974	357	6	significantly	significantly	ADV
fnp-8974	357	7	reduced	reduce	VERB
fnp-8974	357	8	tumor	tumor	NOUN
fnp-8974	357	9	clot	clot	NOUN
fnp-8974	357	10	formation	formation	NOUN
fnp-8974	357	11	,	,	PUNCT
fnp-8974	357	12	and	and	CCONJ
fnp-8974	357	13	the	the	DET
fnp-8974	357	14	development	development	NOUN
fnp-8974	357	15	of	of	ADP
fnp-8974	357	16	parenchymal	parenchymal	ADJ
fnp-8974	357	17	brain	brain	NOUN
fnp-8974	357	18	metastases	metastasis	NOUN
fnp-8974	357	19	.	.	PUNCT
fnp-8974	358	1	conclusion	conclusion	NOUN
fnp-8974	358	2	:	:	PUNCT
fnp-8974	358	3	our	our	PRON
fnp-8974	358	4	findings	finding	NOUN
fnp-8974	358	5	identify	identify	VERB
fnp-8974	358	6	endothelial	endothelial	ADJ
fnp-8974	358	7	activation	activation	NOUN
fnp-8974	358	8	and	and	CCONJ
fnp-8974	358	9	thromboinflammatory	thromboinflammatory	ADJ
fnp-8974	358	10	signaling	signaling	NOUN
fnp-8974	358	11	as	as	ADP
fnp-8974	358	12	key	key	ADJ
fnp-8974	358	13	early	early	ADJ
fnp-8974	358	14	events	event	NOUN
fnp-8974	358	15	in	in	ADP
fnp-8974	358	16	brain	brain	NOUN
fnp-8974	358	17	metastasis	metastasis	NOUN
fnp-8974	358	18	formation	formation	NOUN
fnp-8974	358	19	,	,	PUNCT
fnp-8974	358	20	paralleling	paralleling	ADJ
fnp-8974	358	21	mechanisms	mechanism	NOUN
fnp-8974	358	22	seen	see	VERB
fnp-8974	358	23	in	in	ADP
fnp-8974	358	24	ischemic	ischemic	ADJ
fnp-8974	358	25	stroke	stroke	NOUN
fnp-8974	358	26	.	.	PUNCT
fnp-8974	359	1	these	these	DET
fnp-8974	359	2	insights	insight	NOUN
fnp-8974	359	3	suggest	suggest	VERB
fnp-8974	359	4	that	that	SCONJ
fnp-8974	359	5	combinatory	combinatory	ADJ
fnp-8974	359	6	antithrombotic	antithrombotic	ADJ
fnp-8974	359	7	therapies	therapy	NOUN
fnp-8974	359	8	may	may	AUX
fnp-8974	359	9	offer	offer	VERB
fnp-8974	359	10	a	a	DET
fnp-8974	359	11	viable	viable	ADJ
fnp-8974	359	12	preventive	preventive	ADJ
fnp-8974	359	13	strategy	strategy	NOUN
fnp-8974	359	14	against	against	ADP
fnp-8974	359	15	metastatic	metastatic	ADJ
fnp-8974	359	16	brain	brain	NOUN
fnp-8974	359	17	colonization	colonization	NOUN
fnp-8974	359	18	.	.	PUNCT
fnp-8974	360	1	p28	p28	NOUN
fnp-8974	360	2	free	free	ADJ
fnp-8974	360	3	neuropathol	neuropathol	NOUN
fnp-8974	360	4	6:17:43	6:17:43	NUM
fnp-8974	360	5	molecular	molecular	ADJ
fnp-8974	360	6	and	and	CCONJ
fnp-8974	360	7	histological	histological	ADJ
fnp-8974	360	8	analyses	analysis	NOUN
fnp-8974	360	9	of	of	ADP
fnp-8974	360	10	at	at	ADP
fnp-8974	360	11	/	/	SYM
fnp-8974	360	12	rt	rt	PROPN
fnp-8974	360	13	-	-	PUNCT
fnp-8974	360	14	tyr	tyr	PROPN
fnp-8974	360	15	suggest	suggest	VERB
fnp-8974	360	16	the	the	DET
fnp-8974	360	17	choroid	choroid	NOUN
fnp-8974	360	18	plexus	plexus	NOUN
fnp-8974	360	19	of	of	ADP
fnp-8974	360	20	the	the	DET
fnp-8974	360	21	fourth	fourth	ADJ
fnp-8974	360	22	ventricle	ventricle	NOUN
fnp-8974	360	23	as	as	ADP
fnp-8974	360	24	cellular	cellular	ADJ
fnp-8974	360	25	origin	origin	NOUN
fnp-8974	360	26	lea	lea	PROPN
fnp-8974	360	27	altendorf1,2	altendorf1,2	PROPN
fnp-8974	360	28	,	,	PUNCT
fnp-8974	360	29	levke	levke	NOUN
fnp-8974	360	30	-	-	PUNCT
fnp-8974	360	31	sophie	sophie	NOUN
fnp-8974	360	32	peter1,2	peter1,2	PROPN
fnp-8974	360	33	,	,	PUNCT
fnp-8974	360	34	karoline	karoline	PROPN
fnp-8974	360	35	hack1,2	hack1,2	PROPN
fnp-8974	360	36	,	,	PUNCT
fnp-8974	360	37	matthias	matthias	PROPN
fnp-8974	360	38	dottermusch3	dottermusch3	PROPN
fnp-8974	360	39	,	,	PUNCT
fnp-8974	360	40	svenja	svenja	NOUN
fnp-8974	360	41	tonn1,2	tonn1,2	PROPN
fnp-8974	360	42	,	,	PUNCT
fnp-8974	360	43	rajanya	rajanya	ADJ
fnp-8974	360	44	roy4	roy4	PROPN
fnp-8974	360	45	,	,	PUNCT
fnp-8974	360	46	michael	michael	PROPN
fnp-8974	360	47	j	j	PROPN
fnp-8974	360	48	holtzman5	holtzman5	PROPN
fnp-8974	360	49	,	,	PUNCT
fnp-8974	360	50	christian	christian	PROPN
fnp-8974	360	51	thomas6	thomas6	PROPN
fnp-8974	360	52	,	,	PUNCT
fnp-8974	360	53	kornelius	kornelius	PROPN
fnp-8974	360	54	kerl4	kerl4	PROPN
fnp-8974	360	55	,	,	PUNCT
fnp-8974	360	56	melanie	melanie	PROPN
fnp-8974	360	57	schoof1,2	schoof1,2	PROPN
fnp-8974	360	58	,	,	PUNCT
fnp-8974	360	59	martin	martin	PROPN
fnp-8974	360	60	hasselblatt6	hasselblatt6	PROPN
fnp-8974	360	61	,	,	PUNCT
fnp-8974	360	62	ulrich	ulrich	PROPN
fnp-8974	360	63	schüller1,2,3	schüller1,2,3	VERB
fnp-8974	360	64	1	1	NUM
fnp-8974	360	65	department	department	NOUN
fnp-8974	360	66	of	of	ADP
fnp-8974	360	67	pediatric	pediatric	ADJ
fnp-8974	360	68	hematology	hematology	NOUN
fnp-8974	360	69	and	and	CCONJ
fnp-8974	360	70	oncology	oncology	NOUN
fnp-8974	360	71	,	,	PUNCT
fnp-8974	360	72	university	university	NOUN
fnp-8974	360	73	medical	medical	ADJ
fnp-8974	360	74	center	center	PROPN
fnp-8974	360	75	hamburg	hamburg	PROPN
fnp-8974	360	76	-	-	PUNCT
fnp-8974	360	77	eppendorf	eppendorf	PROPN
fnp-8974	360	78	,	,	PUNCT
fnp-8974	360	79	hamburg	hamburg	PROPN
fnp-8974	360	80	,	,	PUNCT
fnp-8974	360	81	germany	germany	PROPN
fnp-8974	360	82	2	2	NUM
fnp-8974	360	83	research	research	NOUN
fnp-8974	360	84	institute	institute	NOUN
fnp-8974	360	85	children	child	NOUN
fnp-8974	360	86	’s	’s	PART
fnp-8974	360	87	cancer	cancer	NOUN
fnp-8974	360	88	,	,	PUNCT
fnp-8974	360	89	university	university	NOUN
fnp-8974	360	90	medical	medical	ADJ
fnp-8974	360	91	center	center	PROPN
fnp-8974	360	92	hamburg	hamburg	PROPN
fnp-8974	360	93	-	-	PUNCT
fnp-8974	360	94	eppendorf	eppendorf	PROPN
fnp-8974	360	95	,	,	PUNCT
fnp-8974	360	96	hamburg	hamburg	PROPN
fnp-8974	360	97	,	,	PUNCT
fnp-8974	360	98	germany	germany	PROPN
fnp-8974	360	99	3	3	NUM
fnp-8974	360	100	institute	institute	PROPN
fnp-8974	360	101	of	of	ADP
fnp-8974	360	102	neuropathology	neuropathology	NOUN
fnp-8974	360	103	,	,	PUNCT
fnp-8974	360	104	university	university	NOUN
fnp-8974	360	105	medical	medical	ADJ
fnp-8974	360	106	center	center	PROPN
fnp-8974	360	107	hamburg	hamburg	PROPN
fnp-8974	360	108	-	-	PUNCT
fnp-8974	360	109	eppendorf	eppendorf	PROPN
fnp-8974	360	110	,	,	PUNCT
fnp-8974	360	111	hamburg	hamburg	PROPN
fnp-8974	360	112	,	,	PUNCT
fnp-8974	360	113	germany	germany	PROPN
fnp-8974	360	114	4	4	NUM
fnp-8974	360	115	department	department	NOUN
fnp-8974	360	116	of	of	ADP
fnp-8974	360	117	pediatric	pediatric	ADJ
fnp-8974	360	118	hematology	hematology	NOUN
fnp-8974	360	119	and	and	CCONJ
fnp-8974	360	120	oncology	oncology	NOUN
fnp-8974	360	121	,	,	PUNCT
fnp-8974	360	122	university	university	NOUN
fnp-8974	360	123	medical	medical	ADJ
fnp-8974	360	124	center	center	NOUN
fnp-8974	360	125	münster	münster	NOUN
fnp-8974	360	126	,	,	PUNCT
fnp-8974	360	127	münster	münster	PROPN
fnp-8974	360	128	,	,	PUNCT
fnp-8974	360	129	germany	germany	PROPN
fnp-8974	360	130	5	5	NUM
fnp-8974	360	131	pulmonary	pulmonary	ADJ
fnp-8974	360	132	and	and	CCONJ
fnp-8974	360	133	critical	critical	ADJ
fnp-8974	360	134	care	care	NOUN
fnp-8974	360	135	medicine	medicine	NOUN
fnp-8974	360	136	,	,	PUNCT
fnp-8974	360	137	department	department	NOUN
fnp-8974	360	138	of	of	ADP
fnp-8974	360	139	medicine	medicine	NOUN
fnp-8974	360	140	,	,	PUNCT
fnp-8974	360	141	washington	washington	PROPN
fnp-8974	360	142	university	university	PROPN
fnp-8974	360	143	,	,	PUNCT
fnp-8974	360	144	st	st	PROPN
fnp-8974	360	145	.	.	PROPN
fnp-8974	360	146	louis	louis	PROPN
fnp-8974	360	147	,	,	PUNCT
fnp-8974	360	148	united	united	PROPN
fnp-8974	360	149	states	states	PROPN
fnp-8974	360	150	6	6	NUM
fnp-8974	360	151	institute	institute	NOUN
fnp-8974	360	152	of	of	ADP
fnp-8974	360	153	neuropathology	neuropathology	NOUN
fnp-8974	360	154	,	,	PUNCT
fnp-8974	360	155	university	university	NOUN
fnp-8974	360	156	hospital	hospital	NOUN
fnp-8974	360	157	münster	münster	NOUN
fnp-8974	360	158	,	,	PUNCT
fnp-8974	360	159	münster	münster	PROPN
fnp-8974	360	160	,	,	PUNCT
fnp-8974	360	161	germany	germany	PROPN
fnp-8974	360	162	atypical	atypical	ADJ
fnp-8974	360	163	teratoid	teratoid	PROPN
fnp-8974	360	164	/	/	SYM
fnp-8974	360	165	rhabdoid	rhabdoid	NOUN
fnp-8974	360	166	tumors	tumor	NOUN
fnp-8974	360	167	(	(	PUNCT
fnp-8974	360	168	at	at	ADP
fnp-8974	360	169	/	/	SYM
fnp-8974	360	170	rt	rt	NOUN
fnp-8974	360	171	)	)	PUNCT
fnp-8974	360	172	belong	belong	VERB
fnp-8974	360	173	to	to	ADP
fnp-8974	360	174	the	the	DET
fnp-8974	360	175	most	most	ADV
fnp-8974	360	176	common	common	ADJ
fnp-8974	360	177	tumors	tumor	NOUN
fnp-8974	360	178	of	of	ADP
fnp-8974	360	179	the	the	DET
fnp-8974	360	180	central	central	ADJ
fnp-8974	360	181	nervous	nervous	ADJ
fnp-8974	360	182	system	system	NOUN
fnp-8974	360	183	(	(	PUNCT
fnp-8974	360	184	cns	cns	NOUN
fnp-8974	360	185	)	)	PUNCT
fnp-8974	360	186	during	during	ADP
fnp-8974	360	187	infancy	infancy	NOUN
fnp-8974	360	188	.	.	PUNCT
fnp-8974	361	1	they	they	PRON
fnp-8974	361	2	split	split	VERB
fnp-8974	361	3	into	into	ADP
fnp-8974	361	4	four	four	NUM
fnp-8974	361	5	major	major	ADJ
fnp-8974	361	6	dna	dna	PROPN
fnp-8974	361	7	methylation	methylation	NOUN
fnp-8974	361	8	subtypes	subtype	NOUN
fnp-8974	361	9	:	:	PUNCT
fnp-8974	361	10	at	at	ADP
fnp-8974	361	11	/	/	SYM
fnp-8974	361	12	rt	rt	PROPN
fnp-8974	361	13	-	-	PUNCT
fnp-8974	361	14	tyr	tyr	PROPN
fnp-8974	361	15	,	,	PUNCT
fnp-8974	361	16	at	at	ADP
fnp-8974	361	17	/	/	SYM
fnp-8974	361	18	rt	rt	PROPN
fnp-8974	361	19	-	-	PUNCT
fnp-8974	361	20	shh	shh	PROPN
fnp-8974	361	21	,	,	PUNCT
fnp-8974	361	22	at	at	ADP
fnp-8974	361	23	/	/	SYM
fnp-8974	361	24	rt	rt	PROPN
fnp-8974	361	25	-	-	PUNCT
fnp-8974	361	26	myc	myc	NOUN
fnp-8974	361	27	,	,	PUNCT
fnp-8974	361	28	and	and	CCONJ
fnp-8974	361	29	at	at	ADP
fnp-8974	361	30	/	/	SYM
fnp-8974	361	31	rt	rt	NOUN
fnp-8974	361	32	-	-	PUNCT
fnp-8974	361	33	smarca4	smarca4	NOUN
fnp-8974	361	34	.	.	PUNCT
fnp-8974	362	1	each	each	PRON
fnp-8974	362	2	of	of	ADP
fnp-8974	362	3	these	these	DET
fnp-8974	362	4	types	type	NOUN
fnp-8974	362	5	demonstrates	demonstrate	VERB
fnp-8974	362	6	distinct	distinct	ADJ
fnp-8974	362	7	clinical	clinical	ADJ
fnp-8974	362	8	characteristics	characteristic	NOUN
fnp-8974	362	9	and	and	CCONJ
fnp-8974	362	10	gene	gene	NOUN
fnp-8974	362	11	expression	expression	NOUN
fnp-8974	362	12	profiles	profile	NOUN
fnp-8974	362	13	,	,	PUNCT
fnp-8974	362	14	with	with	ADP
fnp-8974	362	15	at	at	ADP
fnp-8974	362	16	/	/	SYM
fnp-8974	362	17	rt	rt	PROPN
fnp-8974	362	18	-	-	PUNCT
fnp-8974	362	19	tyr	tyr	PROPN
fnp-8974	362	20	most	most	ADV
fnp-8974	362	21	frequently	frequently	ADV
fnp-8974	362	22	occurring	occur	VERB
fnp-8974	362	23	in	in	ADP
fnp-8974	362	24	the	the	DET
fnp-8974	362	25	fourth	fourth	ADJ
fnp-8974	362	26	ventricle	ventricle	NOUN
fnp-8974	362	27	.	.	PUNCT
fnp-8974	363	1	however	however	ADV
fnp-8974	363	2	,	,	PUNCT
fnp-8974	363	3	details	detail	NOUN
fnp-8974	363	4	on	on	ADP
fnp-8974	363	5	the	the	DET
fnp-8974	363	6	cellular	cellular	ADJ
fnp-8974	363	7	origins	origin	NOUN
fnp-8974	363	8	and	and	CCONJ
fnp-8974	363	9	tumor	tumor	NOUN
fnp-8974	363	10	initiation	initiation	NOUN
fnp-8974	363	11	of	of	ADP
fnp-8974	363	12	at	at	ADP
fnp-8974	363	13	/	/	SYM
fnp-8974	363	14	rt	rt	PROPN
fnp-8974	363	15	-	-	PUNCT
fnp-8974	363	16	tyr	tyr	PROPN
fnp-8974	363	17	remain	remain	VERB
fnp-8974	363	18	largely	largely	ADV
fnp-8974	363	19	unknown	unknown	ADJ
fnp-8974	363	20	and	and	CCONJ
fnp-8974	363	21	mouse	mouse	NOUN
fnp-8974	363	22	models	model	NOUN
fnp-8974	363	23	providing	provide	VERB
fnp-8974	363	24	insights	insight	NOUN
fnp-8974	363	25	into	into	ADP
fnp-8974	363	26	tumor	tumor	NOUN
fnp-8974	363	27	development	development	NOUN
fnp-8974	363	28	are	be	AUX
fnp-8974	363	29	completely	completely	ADV
fnp-8974	363	30	lacking	lacking	ADJ
fnp-8974	363	31	.	.	PUNCT
fnp-8974	364	1	therefore	therefore	ADV
fnp-8974	364	2	,	,	PUNCT
fnp-8974	364	3	we	we	PRON
fnp-8974	364	4	aim	aim	VERB
fnp-8974	364	5	to	to	PART
fnp-8974	364	6	identify	identify	VERB
fnp-8974	364	7	and	and	CCONJ
fnp-8974	364	8	characterize	characterize	VERB
fnp-8974	364	9	the	the	DET
fnp-8974	364	10	cellular	cellular	ADJ
fnp-8974	364	11	origin	origin	NOUN
fnp-8974	364	12	of	of	ADP
fnp-8974	364	13	at	at	ADP
fnp-8974	364	14	/	/	SYM
fnp-8974	364	15	rt	rt	PROPN
fnp-8974	364	16	-	-	PUNCT
fnp-8974	364	17	tyr	tyr	PROPN
fnp-8974	364	18	.	.	PUNCT
fnp-8974	365	1	we	we	PRON
fnp-8974	365	2	performed	perform	VERB
fnp-8974	365	3	histopathological	histopathological	ADJ
fnp-8974	365	4	examination	examination	NOUN
fnp-8974	365	5	and	and	CCONJ
fnp-8974	365	6	bulkand	bulkand	NOUN
fnp-8974	365	7	single	single	ADJ
fnp-8974	365	8	-	-	PUNCT
fnp-8974	365	9	nucleus	nucleus	NOUN
fnp-8974	365	10	rna	rna	NOUN
fnp-8974	365	11	sequencing	sequencing	NOUN
fnp-8974	365	12	analyses	analysis	NOUN
fnp-8974	365	13	across	across	ADP
fnp-8974	365	14	various	various	ADJ
fnp-8974	365	15	brain	brain	NOUN
fnp-8974	365	16	tumor	tumor	NOUN
fnp-8974	365	17	entities	entity	NOUN
fnp-8974	365	18	.	.	PUNCT
fnp-8974	366	1	genetically	genetically	ADV
fnp-8974	366	2	engineered	engineer	VERB
fnp-8974	366	3	mouse	mouse	NOUN
fnp-8974	366	4	models	model	NOUN
fnp-8974	366	5	with	with	ADP
fnp-8974	366	6	a	a	DET
fnp-8974	366	7	conditional	conditional	ADJ
fnp-8974	366	8	,	,	PUNCT
fnp-8974	366	9	cre	cre	PROPN
fnp-8974	366	10	/	/	SYM
fnp-8974	366	11	loxp	loxp	NOUN
fnp-8974	366	12	-	-	PUNCT
fnp-8974	366	13	induced	induce	VERB
fnp-8974	366	14	smarcb1	smarcb1	NOUN
fnp-8974	366	15	loss	loss	NOUN
fnp-8974	366	16	were	be	AUX
fnp-8974	366	17	generated	generate	VERB
fnp-8974	366	18	.	.	PUNCT
fnp-8974	367	1	here	here	ADV
fnp-8974	367	2	,	,	PUNCT
fnp-8974	367	3	we	we	PRON
fnp-8974	367	4	show	show	VERB
fnp-8974	367	5	that	that	SCONJ
fnp-8974	367	6	at	at	ADP
fnp-8974	367	7	/	/	SYM
fnp-8974	367	8	rt	rt	PROPN
fnp-8974	367	9	-	-	PUNCT
fnp-8974	367	10	tyr	tyr	PROPN
fnp-8974	367	11	very	very	ADV
fnp-8974	367	12	often	often	ADV
fnp-8974	367	13	appear	appear	VERB
fnp-8974	367	14	intermingled	intermingle	VERB
fnp-8974	367	15	with	with	ADP
fnp-8974	367	16	fourth	fourth	ADJ
fnp-8974	367	17	ventricle	ventricle	NOUN
fnp-8974	367	18	choroid	choroid	NOUN
fnp-8974	367	19	plexus	plexus	NOUN
fnp-8974	367	20	(	(	PUNCT
fnp-8974	367	21	cp	cp	NOUN
fnp-8974	367	22	)	)	PUNCT
fnp-8974	367	23	tissue	tissue	NOUN
fnp-8974	367	24	and	and	CCONJ
fnp-8974	367	25	that	that	SCONJ
fnp-8974	367	26	tumor	tumor	NOUN
fnp-8974	367	27	cells	cell	NOUN
fnp-8974	367	28	heavily	heavily	ADV
fnp-8974	367	29	express	express	VERB
fnp-8974	367	30	cp	cp	NUM
fnp-8974	367	31	markers	marker	NOUN
fnp-8974	367	32	.	.	PUNCT
fnp-8974	368	1	analyses	analysis	NOUN
fnp-8974	368	2	of	of	ADP
fnp-8974	368	3	bulkand	bulkand	NOUN
fnp-8974	368	4	single	single	ADJ
fnp-8974	368	5	-	-	PUNCT
fnp-8974	368	6	cell	cell	NOUN
fnp-8974	368	7	rna	rna	NOUN
fnp-8974	368	8	sequencing	sequencing	NOUN
fnp-8974	368	9	data	datum	NOUN
fnp-8974	368	10	reveal	reveal	VERB
fnp-8974	368	11	a	a	DET
fnp-8974	368	12	clear	clear	ADJ
fnp-8974	368	13	resemblance	resemblance	NOUN
fnp-8974	368	14	of	of	ADP
fnp-8974	368	15	the	the	DET
fnp-8974	368	16	at	at	ADP
fnp-8974	368	17	/	/	SYM
fnp-8974	368	18	rt	rt	PROPN
fnp-8974	368	19	-	-	PUNCT
fnp-8974	368	20	tyr	tyr	PROPN
fnp-8974	368	21	to	to	ADP
fnp-8974	368	22	the	the	DET
fnp-8974	368	23	cp	cp	PROPN
fnp-8974	368	24	of	of	ADP
fnp-8974	368	25	the	the	DET
fnp-8974	368	26	fourth	fourth	ADJ
fnp-8974	368	27	ventricle	ventricle	NOUN
fnp-8974	368	28	.	.	PUNCT
fnp-8974	369	1	finally	finally	ADV
fnp-8974	369	2	,	,	PUNCT
fnp-8974	369	3	foxj1	foxj1	PROPN
fnp-8974	369	4	-	-	PUNCT
fnp-8974	369	5	cre::smarcb1fl	cre::smarcb1fl	PROPN
fnp-8974	369	6	/	/	SYM
fnp-8974	369	7	fl	fl	NUM
fnp-8974	369	8	mice	mouse	NOUN
fnp-8974	369	9	showing	show	VERB
fnp-8974	369	10	loss	loss	NOUN
fnp-8974	369	11	of	of	ADP
fnp-8974	369	12	smarcb1	smarcb1	NOUN
fnp-8974	369	13	in	in	ADP
fnp-8974	369	14	early	early	ADJ
fnp-8974	369	15	cp	cp	PROPN
fnp-8974	369	16	progenitors	progenitor	NOUN
fnp-8974	369	17	gave	give	VERB
fnp-8974	369	18	rise	rise	NOUN
fnp-8974	369	19	to	to	ADP
fnp-8974	369	20	large	large	ADJ
fnp-8974	369	21	,	,	PUNCT
fnp-8974	369	22	atypical	atypical	ADJ
fnp-8974	369	23	,	,	PUNCT
fnp-8974	369	24	monociliary	monociliary	ADJ
fnp-8974	369	25	cp	cp	NUM
fnp-8974	369	26	cells	cell	NOUN
fnp-8974	369	27	with	with	ADP
fnp-8974	369	28	gene	gene	NOUN
fnp-8974	369	29	expression	expression	NOUN
fnp-8974	369	30	most	most	ADV
fnp-8974	369	31	similar	similar	ADJ
fnp-8974	369	32	to	to	ADP
fnp-8974	369	33	human	human	NOUN
fnp-8974	369	34	at	at	ADP
fnp-8974	369	35	/	/	SYM
fnp-8974	369	36	rt	rt	PROPN
fnp-8974	369	37	-	-	PUNCT
fnp-8974	369	38	tyr	tyr	PROPN
fnp-8974	369	39	.	.	PUNCT
fnp-8974	370	1	in	in	ADP
fnp-8974	370	2	conclusion	conclusion	NOUN
fnp-8974	370	3	,	,	PUNCT
fnp-8974	370	4	analyses	analysis	NOUN
fnp-8974	370	5	of	of	ADP
fnp-8974	370	6	human	human	NOUN
fnp-8974	370	7	at	at	ADP
fnp-8974	370	8	/	/	SYM
fnp-8974	370	9	rt	rt	PROPN
fnp-8974	370	10	-	-	PUNCT
fnp-8974	370	11	tyr	tyr	PROPN
fnp-8974	370	12	as	as	ADV
fnp-8974	370	13	well	well	ADV
fnp-8974	370	14	as	as	ADP
fnp-8974	370	15	murine	murine	ADJ
fnp-8974	370	16	cp	cp	PROPN
fnp-8974	370	17	cells	cell	NOUN
fnp-8974	370	18	lacking	lack	VERB
fnp-8974	370	19	smarcb1	smarcb1	NOUN
fnp-8974	370	20	point	point	NOUN
fnp-8974	370	21	towards	towards	ADP
fnp-8974	370	22	the	the	DET
fnp-8974	370	23	cp	cp	PROPN
fnp-8974	370	24	of	of	ADP
fnp-8974	370	25	the	the	DET
fnp-8974	370	26	fourth	fourth	ADJ
fnp-8974	370	27	ventricle	ventricle	NOUN
fnp-8974	370	28	as	as	ADP
fnp-8974	370	29	a	a	DET
fnp-8974	370	30	potential	potential	ADJ
fnp-8974	370	31	cellular	cellular	ADJ
fnp-8974	370	32	origin	origin	NOUN
fnp-8974	370	33	of	of	ADP
fnp-8974	370	34	at	at	ADP
fnp-8974	370	35	/	/	SYM
fnp-8974	370	36	rt	rt	PROPN
fnp-8974	370	37	-	-	PUNCT
fnp-8974	370	38	tyr	tyr	PROPN
fnp-8974	370	39	.	.	PUNCT
fnp-8974	370	40	p29	p29	PROPN
fnp-8974	370	41	free	free	ADJ
fnp-8974	370	42	neuropathol	neuropathol	NOUN
fnp-8974	370	43	6:17:44	6:17:44	NUM
fnp-8974	370	44	pediatric	pediatric	ADJ
fnp-8974	370	45	and	and	CCONJ
fnp-8974	370	46	aya	aya	PROPN
fnp-8974	370	47	meningiomas	meningiomas	PROPN
fnp-8974	370	48	exhibit	exhibit	VERB
fnp-8974	370	49	distinct	distinct	ADJ
fnp-8974	370	50	molecular	molecular	ADJ
fnp-8974	370	51	and	and	CCONJ
fnp-8974	370	52	clinical	clinical	ADJ
fnp-8974	370	53	features	feature	NOUN
fnp-8974	370	54	not	not	PART
fnp-8974	370	55	reflected	reflect	VERB
fnp-8974	370	56	in	in	ADP
fnp-8974	370	57	adult	adult	NOUN
fnp-8974	370	58	-	-	PUNCT
fnp-8974	370	59	based	base	VERB
fnp-8974	370	60	classification	classification	NOUN
fnp-8974	370	61	systems	system	NOUN
fnp-8974	370	62	natalie	natalie	PROPN
fnp-8974	370	63	berghaus1	berghaus1	PROPN
fnp-8974	370	64	,	,	PUNCT
fnp-8974	370	65	arnault	arnault	VERB
fnp-8974	370	66	tauziède	tauziède	VERB
fnp-8974	370	67	-	-	PUNCT
fnp-8974	370	68	espariat2	espariat2	NOUN
fnp-8974	370	69	,	,	PUNCT
fnp-8974	370	70	thomas	thomas	PROPN
fnp-8974	370	71	hielscher3	hielscher3	PROPN
fnp-8974	370	72	,	,	PUNCT
fnp-8974	370	73	christian	christian	ADJ
fnp-8974	370	74	mawrin4	mawrin4	PROPN
fnp-8974	370	75	,	,	PUNCT
fnp-8974	370	76	miriam	miriam	PROPN
fnp-8974	370	77	ratliff5	ratliff5	PROPN
fnp-8974	370	78	,	,	PUNCT
fnp-8974	370	79	christel	christel	PROPN
fnp-8974	370	80	herold	herold	PROPN
fnp-8974	370	81	-	-	PUNCT
fnp-8974	370	82	mende6	mende6	PROPN
fnp-8974	370	83	,	,	PUNCT
fnp-8974	370	84	sandro	sandro	PROPN
fnp-8974	370	85	m.	m.	PROPN
fnp-8974	370	86	krieg7	krieg7	PROPN
fnp-8974	370	87	,	,	PUNCT
fnp-8974	370	88	wolfgang	wolfgang	PROPN
fnp-8974	370	89	wick8	wick8	PROPN
fnp-8974	370	90	,	,	PUNCT
fnp-8974	370	91	stefan	stefan	PROPN
fnp-8974	370	92	m.	m.	PROPN
fnp-8974	370	93	pfister9	pfister9	PROPN
fnp-8974	370	94	,	,	PUNCT
fnp-8974	370	95	pieter	pieter	PROPN
fnp-8974	370	96	wesseling10	wesseling10	PROPN
fnp-8974	370	97	,	,	PUNCT
fnp-8974	370	98	andreas	andreas	PROPN
fnp-8974	370	99	von	von	PROPN
fnp-8974	370	100	deimling1	deimling1	PROPN
fnp-8974	370	101	,	,	PUNCT
fnp-8974	370	102	pascale	pascale	PROPN
fnp-8974	370	103	varlet2	varlet2	NOUN
fnp-8974	370	104	,	,	PUNCT
fnp-8974	370	105	felix	felix	PROPN
fnp-8974	370	106	sahm1	sahm1	PROPN
fnp-8974	370	107	,	,	PUNCT
fnp-8974	370	108	philipp	philipp	PROPN
fnp-8974	370	109	sievers1	sievers1	PROPN
fnp-8974	370	110	1	1	NUM
fnp-8974	370	111	department	department	NOUN
fnp-8974	370	112	of	of	ADP
fnp-8974	370	113	neuropathology	neuropathology	NOUN
fnp-8974	370	114	,	,	PUNCT
fnp-8974	370	115	institute	institute	PROPN
fnp-8974	370	116	of	of	ADP
fnp-8974	370	117	pathology	pathology	PROPN
fnp-8974	370	118	,	,	PUNCT
fnp-8974	370	119	university	university	NOUN
fnp-8974	370	120	hospital	hospital	NOUN
fnp-8974	370	121	heidelberg	heidelberg	PROPN
fnp-8974	370	122	,	,	PUNCT
fnp-8974	370	123	heidelberg	heidelberg	PROPN
fnp-8974	370	124	,	,	PUNCT
fnp-8974	370	125	germany	germany	PROPN
fnp-8974	370	126	2	2	NUM
fnp-8974	370	127	department	department	NOUN
fnp-8974	370	128	of	of	ADP
fnp-8974	370	129	neuropathology	neuropathology	NOUN
fnp-8974	370	130	,	,	PUNCT
fnp-8974	370	131	ghu	ghu	PROPN
fnp-8974	370	132	paris	paris	PROPN
fnp-8974	370	133	psychiatry	psychiatry	NOUN
fnp-8974	370	134	and	and	CCONJ
fnp-8974	370	135	neurosciences	neuroscience	NOUN
fnp-8974	370	136	,	,	PUNCT
fnp-8974	370	137	sainte	sainte	PROPN
fnp-8974	370	138	-	-	PUNCT
fnp-8974	370	139	anne	anne	PROPN
fnp-8974	370	140	hospital	hospital	PROPN
fnp-8974	370	141	,	,	PUNCT
fnp-8974	370	142	paris	paris	PROPN
fnp-8974	370	143	,	,	PUNCT
fnp-8974	370	144	france	france	PROPN
fnp-8974	370	145	3	3	NUM
fnp-8974	370	146	division	division	NOUN
fnp-8974	370	147	of	of	ADP
fnp-8974	370	148	biostatistics	biostatistic	NOUN
fnp-8974	370	149	,	,	PUNCT
fnp-8974	370	150	german	german	ADJ
fnp-8974	370	151	cancer	cancer	NOUN
fnp-8974	370	152	research	research	NOUN
fnp-8974	370	153	center	center	NOUN
fnp-8974	370	154	(	(	PUNCT
fnp-8974	370	155	dkfz	dkfz	PROPN
fnp-8974	370	156	)	)	PUNCT
fnp-8974	370	157	,	,	PUNCT
fnp-8974	370	158	heidelberg	heidelberg	PROPN
fnp-8974	370	159	,	,	PUNCT
fnp-8974	370	160	germany	germany	PROPN
fnp-8974	370	161	4	4	NUM
fnp-8974	370	162	department	department	NOUN
fnp-8974	370	163	of	of	ADP
fnp-8974	370	164	neuropathology	neuropathology	NOUN
fnp-8974	370	165	,	,	PUNCT
fnp-8974	370	166	otto	otto	PROPN
fnp-8974	370	167	-	-	PUNCT
fnp-8974	370	168	von	von	PROPN
fnp-8974	370	169	-	-	PUNCT
fnp-8974	370	170	guericke	guericke	NOUN
fnp-8974	370	171	-	-	PUNCT
fnp-8974	370	172	university	university	NOUN
fnp-8974	370	173	,	,	PUNCT
fnp-8974	370	174	magdeburg	magdeburg	PROPN
fnp-8974	370	175	,	,	PUNCT
fnp-8974	370	176	germany	germany	PROPN
fnp-8974	370	177	5	5	NUM
fnp-8974	370	178	neurosurgery	neurosurgery	NOUN
fnp-8974	370	179	clinic	clinic	NOUN
fnp-8974	370	180	,	,	PUNCT
fnp-8974	370	181	university	university	NOUN
fnp-8974	370	182	hospital	hospital	NOUN
fnp-8974	370	183	mannheim	mannheim	PROPN
fnp-8974	370	184	,	,	PUNCT
fnp-8974	370	185	mannheim	mannheim	PROPN
fnp-8974	370	186	,	,	PUNCT
fnp-8974	370	187	germany	germany	PROPN
fnp-8974	370	188	6	6	NUM
fnp-8974	370	189	division	division	NOUN
fnp-8974	370	190	of	of	ADP
fnp-8974	370	191	experimental	experimental	ADJ
fnp-8974	370	192	neurosurgery	neurosurgery	NOUN
fnp-8974	370	193	,	,	PUNCT
fnp-8974	370	194	department	department	NOUN
fnp-8974	370	195	of	of	ADP
fnp-8974	370	196	neurosurgery	neurosurgery	NOUN
fnp-8974	370	197	,	,	PUNCT
fnp-8974	370	198	university	university	NOUN
fnp-8974	370	199	hospital	hospital	NOUN
fnp-8974	370	200	heidelberg	heidelberg	PROPN
fnp-8974	370	201	,	,	PUNCT
fnp-8974	370	202	heidelberg	heidelberg	PROPN
fnp-8974	370	203	,	,	PUNCT
fnp-8974	370	204	germany	germany	PROPN
fnp-8974	370	205	7	7	NUM
fnp-8974	370	206	department	department	NOUN
fnp-8974	370	207	of	of	ADP
fnp-8974	370	208	neurosurgery	neurosurgery	NOUN
fnp-8974	370	209	,	,	PUNCT
fnp-8974	370	210	heidelberg	heidelberg	PROPN
fnp-8974	370	211	university	university	PROPN
fnp-8974	370	212	hospital	hospital	NOUN
fnp-8974	370	213	,	,	PUNCT
fnp-8974	370	214	heidelberg	heidelberg	PROPN
fnp-8974	370	215	,	,	PUNCT
fnp-8974	370	216	germany	germany	PROPN
fnp-8974	370	217	8	8	NUM
fnp-8974	370	218	department	department	PROPN
fnp-8974	370	219	of	of	ADP
fnp-8974	370	220	neurology	neurology	NOUN
fnp-8974	370	221	and	and	CCONJ
fnp-8974	370	222	neurooncology	neurooncology	NOUN
fnp-8974	370	223	program	program	NOUN
fnp-8974	370	224	,	,	PUNCT
fnp-8974	370	225	national	national	ADJ
fnp-8974	370	226	center	center	NOUN
fnp-8974	370	227	for	for	ADP
fnp-8974	370	228	tumor	tumor	NOUN
fnp-8974	370	229	diseases	disease	NOUN
fnp-8974	370	230	,	,	PUNCT
fnp-8974	370	231	heidelberg	heidelberg	PROPN
fnp-8974	370	232	university	university	PROPN
fnp-8974	370	233	hospital	hospital	NOUN
fnp-8974	370	234	,	,	PUNCT
fnp-8974	370	235	heidelberg	heidelberg	PROPN
fnp-8974	370	236	,	,	PUNCT
fnp-8974	370	237	germany	germany	PROPN
fnp-8974	370	238	9	9	NUM
fnp-8974	370	239	hopp	hopp	PROPN
fnp-8974	370	240	children	children	PROPN
fnp-8974	370	241	’s	’s	PART
fnp-8974	370	242	cancer	cancer	NOUN
fnp-8974	370	243	center	center	PROPN
fnp-8974	370	244	heidelberg	heidelberg	PROPN
fnp-8974	370	245	(	(	PUNCT
fnp-8974	370	246	kitz	kitz	PROPN
fnp-8974	370	247	)	)	PUNCT
fnp-8974	370	248	,	,	PUNCT
fnp-8974	370	249	heidelberg	heidelberg	PROPN
fnp-8974	370	250	,	,	PUNCT
fnp-8974	370	251	germany	germany	PROPN
fnp-8974	370	252	10	10	NUM
fnp-8974	370	253	princess	princess	PROPN
fnp-8974	370	254	máxima	máxima	PROPN
fnp-8974	370	255	center	center	NOUN
fnp-8974	370	256	for	for	ADP
fnp-8974	370	257	pediatric	pediatric	ADJ
fnp-8974	370	258	oncology	oncology	NOUN
fnp-8974	370	259	,	,	PUNCT
fnp-8974	370	260	utrecht	utrecht	PROPN
fnp-8974	370	261	,	,	PUNCT
fnp-8974	370	262	netherlands	netherlands	PROPN
fnp-8974	370	263	background	background	NOUN
fnp-8974	370	264	:	:	PUNCT
fnp-8974	370	265	meningiomas	meningioma	NOUN
fnp-8974	370	266	are	be	AUX
fnp-8974	370	267	the	the	DET
fnp-8974	370	268	most	most	ADV
fnp-8974	370	269	common	common	ADJ
fnp-8974	370	270	primary	primary	ADJ
fnp-8974	370	271	intracranial	intracranial	ADJ
fnp-8974	370	272	tumors	tumor	NOUN
fnp-8974	370	273	in	in	ADP
fnp-8974	370	274	adults	adult	NOUN
fnp-8974	370	275	but	but	CCONJ
fnp-8974	370	276	are	be	AUX
fnp-8974	370	277	rare	rare	ADJ
fnp-8974	370	278	in	in	ADP
fnp-8974	370	279	children	child	NOUN
fnp-8974	370	280	and	and	CCONJ
fnp-8974	370	281	adolescents	adolescent	NOUN
fnp-8974	370	282	/	/	SYM
fnp-8974	370	283	young	young	ADJ
fnp-8974	370	284	adults	adult	NOUN
fnp-8974	370	285	(	(	PUNCT
fnp-8974	370	286	aya	aya	PROPN
fnp-8974	370	287	)	)	PUNCT
fnp-8974	370	288	,	,	PUNCT
fnp-8974	370	289	comprising	comprise	VERB
fnp-8974	370	290	only	only	ADV
fnp-8974	370	291	0.4–2.5	0.4–2.5	NOUN
fnp-8974	370	292	 	 	SPACE
fnp-8974	370	293	%	%	NOUN
fnp-8974	370	294	of	of	ADP
fnp-8974	370	295	all	all	DET
fnp-8974	370	296	cases	case	NOUN
fnp-8974	370	297	.	.	PUNCT
fnp-8974	371	1	pediatric	pediatric	ADJ
fnp-8974	371	2	and	and	CCONJ
fnp-8974	371	3	aya	aya	PROPN
fnp-8974	371	4	meningiomas	meningioma	NOUN
fnp-8974	371	5	differ	differ	VERB
fnp-8974	371	6	significantly	significantly	ADV
fnp-8974	371	7	from	from	ADP
fnp-8974	371	8	adult	adult	NOUN
fnp-8974	371	9	counterparts	counterpart	NOUN
fnp-8974	371	10	in	in	ADP
fnp-8974	371	11	epidemiology	epidemiology	NOUN
fnp-8974	371	12	,	,	PUNCT
fnp-8974	371	13	anatomical	anatomical	ADJ
fnp-8974	371	14	location	location	NOUN
fnp-8974	371	15	,	,	PUNCT
fnp-8974	371	16	histopathology	histopathology	NOUN
fnp-8974	371	17	,	,	PUNCT
fnp-8974	371	18	molecular	molecular	ADJ
fnp-8974	371	19	alterations	alteration	NOUN
fnp-8974	371	20	,	,	PUNCT
fnp-8974	371	21	and	and	CCONJ
fnp-8974	371	22	clinical	clinical	ADJ
fnp-8974	371	23	behavior	behavior	NOUN
fnp-8974	371	24	.	.	PUNCT
fnp-8974	372	1	this	this	DET
fnp-8974	372	2	study	study	NOUN
fnp-8974	372	3	aimed	aim	VERB
fnp-8974	372	4	to	to	PART
fnp-8974	372	5	define	define	VERB
fnp-8974	372	6	the	the	DET
fnp-8974	372	7	molecular	molecular	ADJ
fnp-8974	372	8	and	and	CCONJ
fnp-8974	372	9	clinical	clinical	ADJ
fnp-8974	372	10	landscape	landscape	NOUN
fnp-8974	372	11	of	of	ADP
fnp-8974	372	12	meningiomas	meningioma	NOUN
fnp-8974	372	13	in	in	ADP
fnp-8974	372	14	patients	patient	NOUN
fnp-8974	372	15	aged	age	VERB
fnp-8974	372	16	0–39	0–39	NOUN
fnp-8974	372	17	years	year	NOUN
fnp-8974	372	18	and	and	CCONJ
fnp-8974	372	19	to	to	PART
fnp-8974	372	20	evaluate	evaluate	VERB
fnp-8974	372	21	the	the	DET
fnp-8974	372	22	applicability	applicability	NOUN
fnp-8974	372	23	of	of	ADP
fnp-8974	372	24	adult	adult	NOUN
fnp-8974	372	25	-	-	PUNCT
fnp-8974	372	26	derived	derive	VERB
fnp-8974	372	27	prognostic	prognostic	ADJ
fnp-8974	372	28	frameworks	framework	NOUN
fnp-8974	372	29	in	in	ADP
fnp-8974	372	30	this	this	DET
fnp-8974	372	31	population	population	NOUN
fnp-8974	372	32	.	.	PUNCT
fnp-8974	373	1	methods	method	NOUN
fnp-8974	373	2	:	:	PUNCT
fnp-8974	373	3	we	we	PRON
fnp-8974	373	4	analyzed	analyze	VERB
fnp-8974	373	5	294	294	NUM
fnp-8974	373	6	meningiomas	meningioma	NOUN
fnp-8974	373	7	from	from	ADP
fnp-8974	373	8	patients	patient	NOUN
fnp-8974	373	9	aged	age	VERB
fnp-8974	373	10	0–39	0–39	NOUN
fnp-8974	373	11	years	year	NOUN
fnp-8974	373	12	,	,	PUNCT
fnp-8974	373	13	with	with	ADP
fnp-8974	373	14	115	115	NUM
fnp-8974	373	15	patients	patient	NOUN
fnp-8974	373	16	aged	age	VERB
fnp-8974	373	17	0–14	0–14	NOUN
fnp-8974	373	18	and	and	CCONJ
fnp-8974	373	19	179	179	NUM
fnp-8974	373	20	aged	aged	ADJ
fnp-8974	373	21	15–39	15–39	NUM
fnp-8974	373	22	.	.	PUNCT
fnp-8974	374	1	integrated	integrate	VERB
fnp-8974	374	2	analyses	analysis	NOUN
fnp-8974	374	3	included	include	VERB
fnp-8974	374	4	histopathological	histopathological	ADJ
fnp-8974	374	5	evaluation	evaluation	NOUN
fnp-8974	374	6	,	,	PUNCT
fnp-8974	374	7	dna	dna	PROPN
fnp-8974	374	8	methylation	methylation	NOUN
fnp-8974	374	9	profiling	profiling	NOUN
fnp-8974	374	10	,	,	PUNCT
fnp-8974	374	11	copy	copy	NOUN
fnp-8974	374	12	-	-	PUNCT
fnp-8974	374	13	number	number	NOUN
fnp-8974	374	14	analysis	analysis	NOUN
fnp-8974	374	15	,	,	PUNCT
fnp-8974	374	16	targeted	target	VERB
fnp-8974	374	17	next	next	ADJ
fnp-8974	374	18	-	-	PUNCT
fnp-8974	374	19	generation	generation	NOUN
fnp-8974	374	20	sequencing	sequencing	NOUN
fnp-8974	374	21	(	(	PUNCT
fnp-8974	374	22	ngs	ng	NOUN
fnp-8974	374	23	)	)	PUNCT
fnp-8974	374	24	,	,	PUNCT
fnp-8974	374	25	and	and	CCONJ
fnp-8974	374	26	clinical	clinical	ADJ
fnp-8974	374	27	outcome	outcome	NOUN
fnp-8974	374	28	assessment	assessment	NOUN
fnp-8974	374	29	.	.	PUNCT
fnp-8974	375	1	results	result	NOUN
fnp-8974	375	2	:	:	PUNCT
fnp-8974	375	3	the	the	DET
fnp-8974	375	4	cohort	cohort	NOUN
fnp-8974	375	5	showed	show	VERB
fnp-8974	375	6	a	a	DET
fnp-8974	375	7	high	high	ADJ
fnp-8974	375	8	prevalence	prevalence	NOUN
fnp-8974	375	9	of	of	ADP
fnp-8974	375	10	nf2	nf2	NOUN
fnp-8974	375	11	-	-	PUNCT
fnp-8974	375	12	driven	drive	VERB
fnp-8974	375	13	and	and	CCONJ
fnp-8974	375	14	smarce1	smarce1	NOUN
fnp-8974	375	15	-	-	PUNCT
fnp-8974	375	16	altered	alter	VERB
fnp-8974	375	17	tumors	tumor	NOUN
fnp-8974	375	18	,	,	PUNCT
fnp-8974	375	19	often	often	ADV
fnp-8974	375	20	in	in	ADP
fnp-8974	375	21	a	a	DET
fnp-8974	375	22	hereditary	hereditary	ADJ
fnp-8974	375	23	context	context	NOUN
fnp-8974	375	24	.	.	PUNCT
fnp-8974	376	1	in	in	ADP
fnp-8974	376	2	contrast	contrast	NOUN
fnp-8974	376	3	,	,	PUNCT
fnp-8974	376	4	high	high	ADJ
fnp-8974	376	5	-	-	PUNCT
fnp-8974	376	6	risk	risk	NOUN
fnp-8974	376	7	alterations	alteration	NOUN
fnp-8974	376	8	common	common	ADJ
fnp-8974	376	9	in	in	ADP
fnp-8974	376	10	adult	adult	NOUN
fnp-8974	376	11	meningiomas	meningioma	NOUN
fnp-8974	376	12	,	,	PUNCT
fnp-8974	376	13	such	such	ADJ
fnp-8974	376	14	as	as	ADP
fnp-8974	376	15	tert	tert	NOUN
fnp-8974	376	16	promoter	promoter	NOUN
fnp-8974	376	17	mutations	mutation	NOUN
fnp-8974	376	18	and	and	CCONJ
fnp-8974	376	19	homozygous	homozygous	ADJ
fnp-8974	376	20	cdkn2a	cdkn2a	PROPN
fnp-8974	376	21	/	/	SYM
fnp-8974	376	22	b	b	NOUN
fnp-8974	376	23	deletions	deletion	NOUN
fnp-8974	376	24	,	,	PUNCT
fnp-8974	376	25	were	be	AUX
fnp-8974	376	26	nearly	nearly	ADV
fnp-8974	376	27	absent	absent	ADJ
fnp-8974	376	28	.	.	PUNCT
fnp-8974	377	1	established	establish	VERB
fnp-8974	377	2	grading	grade	VERB
fnp-8974	377	3	parameters	parameter	NOUN
fnp-8974	377	4	based	base	VERB
fnp-8974	377	5	on	on	ADP
fnp-8974	377	6	histology	histology	NOUN
fnp-8974	377	7	,	,	PUNCT
fnp-8974	377	8	methylation	methylation	NOUN
fnp-8974	377	9	class	class	NOUN
fnp-8974	377	10	,	,	PUNCT
fnp-8974	377	11	and	and	CCONJ
fnp-8974	377	12	copy	copy	NOUN
fnp-8974	377	13	-	-	PUNCT
fnp-8974	377	14	number	number	NOUN
fnp-8974	377	15	alterations	alteration	NOUN
fnp-8974	377	16	failed	fail	VERB
fnp-8974	377	17	to	to	PART
fnp-8974	377	18	reliably	reliably	ADV
fnp-8974	377	19	predict	predict	VERB
fnp-8974	377	20	clinical	clinical	ADJ
fnp-8974	377	21	outcomes	outcome	NOUN
fnp-8974	377	22	.	.	PUNCT
fnp-8974	378	1	the	the	DET
fnp-8974	378	2	tumor	tumor	NOUN
fnp-8974	378	3	microenvironment	microenvironment	NOUN
fnp-8974	378	4	resembled	resemble	VERB
fnp-8974	378	5	that	that	PRON
fnp-8974	378	6	of	of	ADP
fnp-8974	378	7	adult	adult	NOUN
fnp-8974	378	8	meningiomas	meningioma	NOUN
fnp-8974	378	9	but	but	CCONJ
fnp-8974	378	10	did	do	AUX
fnp-8974	378	11	not	not	PART
fnp-8974	378	12	correlate	correlate	VERB
fnp-8974	378	13	with	with	ADP
fnp-8974	378	14	prognosis	prognosis	NOUN
fnp-8974	378	15	.	.	PUNCT
fnp-8974	379	1	instead	instead	ADV
fnp-8974	379	2	,	,	PUNCT
fnp-8974	379	3	favorable	favorable	ADJ
fnp-8974	379	4	outcomes	outcome	NOUN
fnp-8974	379	5	were	be	AUX
fnp-8974	379	6	primarily	primarily	ADV
fnp-8974	379	7	linked	link	VERB
fnp-8974	379	8	to	to	ADP
fnp-8974	379	9	extent	extent	NOUN
fnp-8974	379	10	of	of	ADP
fnp-8974	379	11	resection	resection	NOUN
fnp-8974	379	12	and	and	CCONJ
fnp-8974	379	13	specific	specific	ADJ
fnp-8974	379	14	chromosomal	chromosomal	ADJ
fnp-8974	379	15	gains	gain	NOUN
fnp-8974	379	16	.	.	PUNCT
fnp-8974	380	1	conclusions	conclusion	NOUN
fnp-8974	380	2	:	:	PUNCT
fnp-8974	380	3	pediatric	pediatric	ADJ
fnp-8974	380	4	and	and	CCONJ
fnp-8974	380	5	aya	aya	PROPN
fnp-8974	380	6	meningiomas	meningiomas	PROPN
fnp-8974	380	7	constitute	constitute	VERB
fnp-8974	380	8	a	a	DET
fnp-8974	380	9	biologically	biologically	ADV
fnp-8974	380	10	distinct	distinct	ADJ
fnp-8974	380	11	subgroup	subgroup	NOUN
fnp-8974	380	12	with	with	ADP
fnp-8974	380	13	unique	unique	ADJ
fnp-8974	380	14	molecular	molecular	ADJ
fnp-8974	380	15	features	feature	NOUN
fnp-8974	380	16	and	and	CCONJ
fnp-8974	380	17	clinical	clinical	ADJ
fnp-8974	380	18	behavior	behavior	NOUN
fnp-8974	380	19	.	.	PUNCT
fnp-8974	381	1	current	current	ADJ
fnp-8974	381	2	adult	adult	NOUN
fnp-8974	381	3	-	-	PUNCT
fnp-8974	381	4	based	base	VERB
fnp-8974	381	5	classification	classification	NOUN
fnp-8974	381	6	and	and	CCONJ
fnp-8974	381	7	risk	risk	NOUN
fnp-8974	381	8	stratification	stratification	NOUN
fnp-8974	381	9	systems	system	NOUN
fnp-8974	381	10	are	be	AUX
fnp-8974	381	11	inadequate	inadequate	ADJ
fnp-8974	381	12	for	for	ADP
fnp-8974	381	13	this	this	DET
fnp-8974	381	14	population	population	NOUN
fnp-8974	381	15	,	,	PUNCT
fnp-8974	381	16	underscoring	underscore	VERB
fnp-8974	381	17	the	the	DET
fnp-8974	381	18	need	need	NOUN
fnp-8974	381	19	for	for	ADP
fnp-8974	381	20	age	age	NOUN
fnp-8974	381	21	-	-	PUNCT
fnp-8974	381	22	specific	specific	ADJ
fnp-8974	381	23	diagnostic	diagnostic	ADJ
fnp-8974	381	24	and	and	CCONJ
fnp-8974	381	25	prognostic	prognostic	ADJ
fnp-8974	381	26	models	model	NOUN
fnp-8974	381	27	.	.	PUNCT
fnp-8974	382	1	p30	p30	VERB
fnp-8974	382	2	free	free	ADJ
fnp-8974	382	3	neuropathol	neuropathol	NOUN
fnp-8974	383	1	6:17:46	6:17:46	NUM
fnp-8974	383	2	case	case	NOUN
fnp-8974	383	3	of	of	ADP
fnp-8974	383	4	a	a	DET
fnp-8974	383	5	myxopapillary	myxopapillary	ADJ
fnp-8974	383	6	ependymoma	ependymoma	NOUN
fnp-8974	383	7	with	with	ADP
fnp-8974	383	8	multiple	multiple	ADJ
fnp-8974	383	9	relapses	relapse	NOUN
fnp-8974	383	10	and	and	CCONJ
fnp-8974	383	11	pulmonary	pulmonary	ADJ
fnp-8974	383	12	metastasis	metastasis	NOUN
fnp-8974	383	13	catena	catena	PROPN
fnp-8974	383	14	kresbach1,2	kresbach1,2	PROPN
fnp-8974	383	15	,	,	PUNCT
fnp-8974	383	16	karoline	karoline	PROPN
fnp-8974	383	17	hack2	hack2	PROPN
fnp-8974	383	18	,	,	PUNCT
fnp-8974	383	19	ulrich	ulrich	PROPN
fnp-8974	383	20	schüller1,2	schüller1,2	PROPN
fnp-8974	383	21	1	1	NUM
fnp-8974	383	22	institut	institut	PROPN
fnp-8974	383	23	für	für	PROPN
fnp-8974	383	24	neuropathologie	neuropathologie	PROPN
fnp-8974	383	25	,	,	PUNCT
fnp-8974	383	26	universitätsklinikum	universitätsklinikum	ADJ
fnp-8974	383	27	hamburg	hamburg	NOUN
fnp-8974	383	28	-	-	PUNCT
fnp-8974	383	29	eppendorf	eppendorf	PROPN
fnp-8974	383	30	,	,	PUNCT
fnp-8974	383	31	hamburg	hamburg	PROPN
fnp-8974	383	32	,	,	PUNCT
fnp-8974	383	33	germany	germany	PROPN
fnp-8974	383	34	2	2	NUM
fnp-8974	383	35	forschungsinstitut	forschungsinstitut	PROPN
fnp-8974	383	36	kinderkrebs	kinderkrebs	PROPN
fnp-8974	383	37	-	-	PUNCT
fnp-8974	383	38	zentrum	zentrum	PROPN
fnp-8974	383	39	hamburg	hamburg	PROPN
fnp-8974	383	40	,	,	PUNCT
fnp-8974	383	41	hamburg	hamburg	PROPN
fnp-8974	383	42	,	,	PUNCT
fnp-8974	383	43	germany	germany	PROPN
fnp-8974	383	44	background	background	NOUN
fnp-8974	383	45	:	:	PUNCT
fnp-8974	383	46	myxopapillary	myxopapillary	ADJ
fnp-8974	383	47	ependymoma	ependymoma	NOUN
fnp-8974	383	48	(	(	PUNCT
fnp-8974	383	49	mpe	mpe	X
fnp-8974	383	50	)	)	PUNCT
fnp-8974	383	51	is	be	AUX
fnp-8974	383	52	a	a	DET
fnp-8974	383	53	clinically	clinically	ADV
fnp-8974	383	54	heterogenous	heterogenous	ADJ
fnp-8974	383	55	disease	disease	NOUN
fnp-8974	383	56	.	.	PUNCT
fnp-8974	384	1	while	while	SCONJ
fnp-8974	384	2	histopathological	histopathological	ADJ
fnp-8974	384	3	diagnosis	diagnosis	NOUN
fnp-8974	384	4	is	be	AUX
fnp-8974	384	5	straightforward	straightforward	ADJ
fnp-8974	384	6	,	,	PUNCT
fnp-8974	384	7	combining	combine	VERB
fnp-8974	384	8	histomorphology	histomorphology	NOUN
fnp-8974	384	9	with	with	ADP
fnp-8974	384	10	hoxb13	hoxb13	PROPN
fnp-8974	384	11	immunohistochemistry	immunohistochemistry	PROPN
fnp-8974	384	12	,	,	PUNCT
fnp-8974	384	13	predicting	predict	VERB
fnp-8974	384	14	the	the	DET
fnp-8974	384	15	clinical	clinical	ADJ
fnp-8974	384	16	course	course	NOUN
fnp-8974	384	17	of	of	ADP
fnp-8974	384	18	mpe	mpe	PROPN
fnp-8974	384	19	is	be	AUX
fnp-8974	384	20	challenging	challenge	VERB
fnp-8974	384	21	.	.	PUNCT
fnp-8974	385	1	approximately	approximately	ADV
fnp-8974	385	2	half	half	NOUN
fnp-8974	385	3	of	of	ADP
fnp-8974	385	4	the	the	DET
fnp-8974	385	5	patients	patient	NOUN
fnp-8974	385	6	experience	experience	VERB
fnp-8974	385	7	local	local	ADJ
fnp-8974	385	8	or	or	CCONJ
fnp-8974	385	9	even	even	ADV
fnp-8974	385	10	distant	distant	ADJ
fnp-8974	385	11	recurrences	recurrence	NOUN
fnp-8974	385	12	.	.	PUNCT
fnp-8974	386	1	objectives	objective	NOUN
fnp-8974	386	2	:	:	PUNCT
fnp-8974	386	3	investigate	investigate	VERB
fnp-8974	386	4	prognostic	prognostic	ADJ
fnp-8974	386	5	and	and	CCONJ
fnp-8974	386	6	therapeutic	therapeutic	ADJ
fnp-8974	386	7	molecular	molecular	ADJ
fnp-8974	386	8	characteristics	characteristic	NOUN
fnp-8974	386	9	in	in	ADP
fnp-8974	386	10	mpe	mpe	PROPN
fnp-8974	386	11	in	in	ADP
fnp-8974	386	12	an	an	DET
fnp-8974	386	13	exemplary	exemplary	ADJ
fnp-8974	386	14	case	case	NOUN
fnp-8974	386	15	and	and	CCONJ
fnp-8974	386	16	a	a	DET
fnp-8974	386	17	small	small	ADJ
fnp-8974	386	18	mpe	mpe	NOUN
fnp-8974	386	19	cohort	cohort	NOUN
fnp-8974	386	20	.	.	PUNCT
fnp-8974	387	1	results	result	NOUN
fnp-8974	387	2	:	:	PUNCT
fnp-8974	387	3	we	we	PRON
fnp-8974	387	4	report	report	VERB
fnp-8974	387	5	the	the	DET
fnp-8974	387	6	case	case	NOUN
fnp-8974	387	7	of	of	ADP
fnp-8974	387	8	a	a	DET
fnp-8974	387	9	30	30	NUM
fnp-8974	387	10	year	year	NOUN
fnp-8974	387	11	old	old	ADJ
fnp-8974	387	12	female	female	ADJ
fnp-8974	387	13	patient	patient	NOUN
fnp-8974	387	14	diagnosed	diagnose	VERB
fnp-8974	387	15	with	with	ADP
fnp-8974	387	16	a	a	DET
fnp-8974	387	17	presacral	presacral	ADJ
fnp-8974	387	18	mpe	mpe	NOUN
fnp-8974	387	19	which	which	PRON
fnp-8974	387	20	was	be	AUX
fnp-8974	387	21	surgically	surgically	ADV
fnp-8974	387	22	resected	resect	VERB
fnp-8974	387	23	.	.	PUNCT
fnp-8974	388	1	she	she	PRON
fnp-8974	388	2	suffered	suffer	VERB
fnp-8974	388	3	from	from	ADP
fnp-8974	388	4	three	three	NUM
fnp-8974	388	5	local	local	ADJ
fnp-8974	388	6	relapses	relapse	NOUN
fnp-8974	388	7	3	3	NUM
fnp-8974	388	8	,	,	PUNCT
fnp-8974	388	9	15	15	NUM
fnp-8974	388	10	,	,	PUNCT
fnp-8974	388	11	and	and	CCONJ
fnp-8974	388	12	17	17	NUM
fnp-8974	388	13	years	year	NOUN
fnp-8974	388	14	after	after	ADP
fnp-8974	388	15	primary	primary	ADJ
fnp-8974	388	16	resection	resection	NOUN
fnp-8974	388	17	and	and	CCONJ
fnp-8974	388	18	was	be	AUX
fnp-8974	388	19	treated	treat	VERB
fnp-8974	388	20	with	with	ADP
fnp-8974	388	21	repeated	repeat	VERB
fnp-8974	388	22	resections	resection	NOUN
fnp-8974	388	23	and	and	CCONJ
fnp-8974	388	24	adjuvant	adjuvant	ADJ
fnp-8974	388	25	irradiation	irradiation	NOUN
fnp-8974	388	26	.	.	PUNCT
fnp-8974	389	1	recently	recently	ADV
fnp-8974	389	2	,	,	PUNCT
fnp-8974	389	3	at	at	ADP
fnp-8974	389	4	the	the	DET
fnp-8974	389	5	age	age	NOUN
fnp-8974	389	6	of	of	ADP
fnp-8974	389	7	53	53	NUM
fnp-8974	389	8	,	,	PUNCT
fnp-8974	389	9	the	the	DET
fnp-8974	389	10	patient	patient	NOUN
fnp-8974	389	11	was	be	AUX
fnp-8974	389	12	diagnosed	diagnose	VERB
fnp-8974	389	13	with	with	ADP
fnp-8974	389	14	mpe	mpe	ADJ
fnp-8974	389	15	metastasis	metastasis	NOUN
fnp-8974	389	16	to	to	ADP
fnp-8974	389	17	mediastinal	mediastinal	ADJ
fnp-8974	389	18	lymph	lymph	NOUN
fnp-8974	389	19	nodes	node	NOUN
fnp-8974	389	20	,	,	PUNCT
fnp-8974	389	21	pleura	pleura	NOUN
fnp-8974	389	22	and	and	CCONJ
fnp-8974	389	23	lung	lung	NOUN
fnp-8974	389	24	.	.	PUNCT
fnp-8974	390	1	methylation	methylation	NOUN
fnp-8974	390	2	profiling	profiling	NOUN
fnp-8974	390	3	indicated	indicate	VERB
fnp-8974	390	4	a	a	DET
fnp-8974	390	5	strong	strong	ADJ
fnp-8974	390	6	methylation	methylation	NOUN
fnp-8974	390	7	of	of	ADP
fnp-8974	390	8	the	the	DET
fnp-8974	390	9	mgmt	mgmt	PROPN
fnp-8974	390	10	promotor	promotor	NOUN
fnp-8974	390	11	.	.	PUNCT
fnp-8974	391	1	treatment	treatment	NOUN
fnp-8974	391	2	with	with	ADP
fnp-8974	391	3	temozolomide	temozolomide	NOUN
fnp-8974	391	4	was	be	AUX
fnp-8974	391	5	initiated	initiate	VERB
fnp-8974	391	6	.	.	PUNCT
fnp-8974	392	1	the	the	DET
fnp-8974	392	2	methylation	methylation	NOUN
fnp-8974	392	3	profile	profile	NOUN
fnp-8974	392	4	matched	match	VERB
fnp-8974	392	5	the	the	DET
fnp-8974	392	6	published	publish	VERB
fnp-8974	392	7	subgroup	subgroup	NOUN
fnp-8974	392	8	mpe	mpe	PROPN
fnp-8974	392	9	-	-	PUNCT
fnp-8974	392	10	a	a	PRON
fnp-8974	392	11	which	which	PRON
fnp-8974	392	12	is	be	AUX
fnp-8974	392	13	correlated	correlate	VERB
fnp-8974	392	14	with	with	ADP
fnp-8974	392	15	a	a	DET
fnp-8974	392	16	high	high	ADJ
fnp-8974	392	17	10	10	NUM
fnp-8974	392	18	-	-	PUNCT
fnp-8974	392	19	year	year	NOUN
fnp-8974	392	20	relapse	relapse	NOUN
fnp-8974	392	21	rate	rate	NOUN
fnp-8974	392	22	of	of	ADP
fnp-8974	392	23	85	85	NUM
fnp-8974	392	24	 	 	SPACE
fnp-8974	392	25	%	%	NOUN
fnp-8974	392	26	(	(	PUNCT
fnp-8974	392	27	bockmayr	bockmayr	NOUN
fnp-8974	392	28	et	et	PROPN
fnp-8974	392	29	al	al	PROPN
fnp-8974	392	30	.	.	PROPN
fnp-8974	392	31	,	,	PUNCT
fnp-8974	392	32	2022	2022	NUM
fnp-8974	392	33	)	)	PUNCT
fnp-8974	392	34	.	.	PUNCT
fnp-8974	393	1	additionally	additionally	ADV
fnp-8974	393	2	,	,	PUNCT
fnp-8974	393	3	we	we	PRON
fnp-8974	393	4	detected	detect	VERB
fnp-8974	393	5	high	high	ADJ
fnp-8974	393	6	expression	expression	NOUN
fnp-8974	393	7	of	of	ADP
fnp-8974	393	8	pdgfra	pdgfra	NOUN
fnp-8974	393	9	in	in	ADP
fnp-8974	393	10	the	the	DET
fnp-8974	393	11	lung	lung	NOUN
fnp-8974	393	12	metastasis	metastasis	NOUN
fnp-8974	393	13	and	and	CCONJ
fnp-8974	393	14	the	the	DET
fnp-8974	393	15	relapses	relapse	NOUN
fnp-8974	393	16	.	.	PUNCT
fnp-8974	394	1	our	our	PRON
fnp-8974	394	2	preliminary	preliminary	ADJ
fnp-8974	394	3	analyses	analysis	NOUN
fnp-8974	394	4	in	in	ADP
fnp-8974	394	5	a	a	DET
fnp-8974	394	6	cohort	cohort	NOUN
fnp-8974	394	7	of	of	ADP
fnp-8974	394	8	25	25	NUM
fnp-8974	394	9	mpe	mpe	NOUN
fnp-8974	394	10	indicate	indicate	VERB
fnp-8974	394	11	that	that	SCONJ
fnp-8974	394	12	pdgfra	pdgfra	NOUN
fnp-8974	394	13	is	be	AUX
fnp-8974	394	14	overexpressed	overexpresse	VERB
fnp-8974	394	15	in	in	ADP
fnp-8974	394	16	mpe	mpe	X
fnp-8974	394	17	with	with	ADP
fnp-8974	394	18	elevated	elevated	ADJ
fnp-8974	394	19	risk	risk	NOUN
fnp-8974	394	20	for	for	ADP
fnp-8974	394	21	relapse	relapse	NOUN
fnp-8974	394	22	.	.	PUNCT
fnp-8974	395	1	conclusion	conclusion	NOUN
fnp-8974	395	2	:	:	PUNCT
fnp-8974	395	3	in	in	ADP
fnp-8974	395	4	summary	summary	NOUN
fnp-8974	395	5	,	,	PUNCT
fnp-8974	395	6	we	we	PRON
fnp-8974	395	7	present	present	VERB
fnp-8974	395	8	an	an	DET
fnp-8974	395	9	unusual	unusual	ADJ
fnp-8974	395	10	case	case	NOUN
fnp-8974	395	11	of	of	ADP
fnp-8974	395	12	mpe	mpe	PROPN
fnp-8974	395	13	with	with	ADP
fnp-8974	395	14	multiple	multiple	ADJ
fnp-8974	395	15	local	local	ADJ
fnp-8974	395	16	recurrences	recurrence	NOUN
fnp-8974	395	17	and	and	CCONJ
fnp-8974	395	18	pulmonary	pulmonary	ADJ
fnp-8974	395	19	metastasis	metastasis	NOUN
fnp-8974	395	20	.	.	PUNCT
fnp-8974	396	1	its	its	PRON
fnp-8974	396	2	epigenetic	epigenetic	ADJ
fnp-8974	396	3	profile	profile	NOUN
fnp-8974	396	4	of	of	ADP
fnp-8974	396	5	mpe	mpe	NOUN
fnp-8974	396	6	-	-	PUNCT
fnp-8974	396	7	a	a	NOUN
fnp-8974	396	8	is	be	AUX
fnp-8974	396	9	in	in	ADP
fnp-8974	396	10	line	line	NOUN
fnp-8974	396	11	with	with	ADP
fnp-8974	396	12	the	the	DET
fnp-8974	396	13	poor	poor	ADJ
fnp-8974	396	14	prognosis	prognosis	NOUN
fnp-8974	396	15	of	of	ADP
fnp-8974	396	16	this	this	DET
fnp-8974	396	17	subgroup	subgroup	NOUN
fnp-8974	396	18	.	.	PUNCT
fnp-8974	397	1	first	first	ADJ
fnp-8974	397	2	data	datum	NOUN
fnp-8974	397	3	indicate	indicate	VERB
fnp-8974	397	4	that	that	SCONJ
fnp-8974	397	5	expression	expression	NOUN
fnp-8974	397	6	of	of	ADP
fnp-8974	397	7	pdgfra	pdgfra	NOUN
fnp-8974	397	8	in	in	ADP
fnp-8974	397	9	mpe	mpe	PROPN
fnp-8974	397	10	might	might	AUX
fnp-8974	397	11	be	be	AUX
fnp-8974	397	12	an	an	DET
fnp-8974	397	13	additional	additional	ADJ
fnp-8974	397	14	marker	marker	NOUN
fnp-8974	397	15	of	of	ADP
fnp-8974	397	16	a	a	DET
fnp-8974	397	17	more	more	ADV
fnp-8974	397	18	aggressive	aggressive	ADJ
fnp-8974	397	19	biology	biology	NOUN
fnp-8974	397	20	and	and	CCONJ
fnp-8974	397	21	a	a	DET
fnp-8974	397	22	new	new	ADJ
fnp-8974	397	23	therapeutic	therapeutic	ADJ
fnp-8974	397	24	target	target	NOUN
fnp-8974	397	25	.	.	PUNCT
fnp-8974	398	1	p31	p31	PROPN
fnp-8974	398	2	free	free	ADJ
fnp-8974	398	3	neuropathol	neuropathol	NOUN
fnp-8974	398	4	6:17:47	6:17:47	NUM
fnp-8974	398	5	unravelling	unravel	VERB
fnp-8974	398	6	ependymoma	ependymoma	NOUN
fnp-8974	398	7	heterogeneity	heterogeneity	NOUN
fnp-8974	398	8	using	use	VERB
fnp-8974	398	9	integrated	integrated	ADJ
fnp-8974	398	10	proteomic	proteomic	NOUN
fnp-8974	398	11	analyses	analysis	NOUN
fnp-8974	398	12	antonia	antonia	PROPN
fnp-8974	398	13	gocke1,2	gocke1,2	PROPN
fnp-8974	398	14	,	,	PUNCT
fnp-8974	398	15	shweta	shweta	PROPN
fnp-8974	398	16	godbole1	godbole1	PROPN
fnp-8974	398	17	,	,	PUNCT
fnp-8974	398	18	lisa	lisa	PROPN
fnp-8974	398	19	siemers1	siemers1	PROPN
fnp-8974	398	20	,	,	PUNCT
fnp-8974	398	21	bente	bente	PROPN
fnp-8974	398	22	siebels2	siebels2	PROPN
fnp-8974	398	23	,	,	PUNCT
fnp-8974	398	24	claire	claire	PROPN
fnp-8974	398	25	delbridge3	delbridge3	PROPN
fnp-8974	398	26	,	,	PUNCT
fnp-8974	398	27	christian	christian	PROPN
fnp-8974	398	28	thomas4	thomas4	PROPN
fnp-8974	398	29	,	,	PUNCT
fnp-8974	398	30	martin	martin	PROPN
fnp-8974	398	31	mynarek5,6	mynarek5,6	PROPN
fnp-8974	398	32	,	,	PUNCT
fnp-8974	398	33	denise	denise	PROPN
fnp-8974	398	34	obrecht	obrecht	PROPN
fnp-8974	398	35	-	-	PUNCT
fnp-8974	398	36	sturm6	sturm6	PROPN
fnp-8974	398	37	,	,	PUNCT
fnp-8974	398	38	lan	lan	PROPN
fnp-8974	398	39	kluwe7,8	kluwe7,8	PROPN
fnp-8974	398	40	,	,	PUNCT
fnp-8974	398	41	said	say	VERB
fnp-8974	398	42	farschtschi8	farschtschi8	PROPN
fnp-8974	398	43	,	,	PUNCT
fnp-8974	398	44	mario	mario	PROPN
fnp-8974	398	45	dorostkar9,10	dorostkar9,10	PROPN
fnp-8974	398	46	,	,	PUNCT
fnp-8974	398	47	viktoria	viktoria	PROPN
fnp-8974	398	48	ruf9	ruf9	PROPN
fnp-8974	398	49	,	,	PUNCT
fnp-8974	398	50	stefan	stefan	PROPN
fnp-8974	398	51	rutkowski6	rutkowski6	PROPN
fnp-8974	398	52	,	,	PUNCT
fnp-8974	398	53	hartmut	hartmut	ADJ
fnp-8974	398	54	schlüter2	schlüter2	NOUN
fnp-8974	398	55	,	,	PUNCT
fnp-8974	398	56	ulrich	ulrich	NOUN
fnp-8974	398	57	schüller6,11,12	schüller6,11,12	PROPN
fnp-8974	398	58	,	,	PUNCT
fnp-8974	398	59	julia	julia	PROPN
fnp-8974	398	60	neumann1,11	neumann1,11	PROPN
fnp-8974	398	61	1	1	NUM
fnp-8974	398	62	center	center	NOUN
fnp-8974	398	63	for	for	ADP
fnp-8974	398	64	molecular	molecular	ADJ
fnp-8974	398	65	neurobiology	neurobiology	NOUN
fnp-8974	398	66	(	(	PUNCT
fnp-8974	398	67	zmnh	zmnh	NOUN
fnp-8974	398	68	)	)	PUNCT
fnp-8974	398	69	,	,	PUNCT
fnp-8974	398	70	university	university	NOUN
fnp-8974	398	71	medical	medical	ADJ
fnp-8974	398	72	center	center	PROPN
fnp-8974	398	73	hamburg	hamburg	PROPN
fnp-8974	398	74	-	-	PUNCT
fnp-8974	398	75	eppendorf	eppendorf	PROPN
fnp-8974	398	76	,	,	PUNCT
fnp-8974	398	77	hamburg	hamburg	PROPN
fnp-8974	398	78	,	,	PUNCT
fnp-8974	398	79	germany	germany	PROPN
fnp-8974	398	80	2	2	NUM
fnp-8974	398	81	section	section	NOUN
fnp-8974	398	82	of	of	ADP
fnp-8974	398	83	mass	mass	ADJ
fnp-8974	398	84	spectrometric	spectrometric	ADJ
fnp-8974	398	85	proteomics	proteomic	NOUN
fnp-8974	398	86	,	,	PUNCT
fnp-8974	398	87	university	university	NOUN
fnp-8974	398	88	medical	medical	ADJ
fnp-8974	398	89	center	center	PROPN
fnp-8974	398	90	hamburg	hamburg	PROPN
fnp-8974	398	91	-	-	PUNCT
fnp-8974	398	92	eppendorf	eppendorf	PROPN
fnp-8974	398	93	,	,	PUNCT
fnp-8974	398	94	hamburg	hamburg	PROPN
fnp-8974	398	95	,	,	PUNCT
fnp-8974	398	96	germany	germany	PROPN
fnp-8974	398	97	3	3	NUM
fnp-8974	398	98	institute	institute	PROPN
fnp-8974	398	99	of	of	ADP
fnp-8974	398	100	pathology	pathology	PROPN
fnp-8974	398	101	,	,	PUNCT
fnp-8974	398	102	school	school	NOUN
fnp-8974	398	103	of	of	ADP
fnp-8974	398	104	medicine	medicine	NOUN
fnp-8974	398	105	and	and	CCONJ
fnp-8974	398	106	health	health	NOUN
fnp-8974	398	107	,	,	PUNCT
fnp-8974	398	108	technical	technical	ADJ
fnp-8974	398	109	university	university	PROPN
fnp-8974	398	110	of	of	ADP
fnp-8974	398	111	munich	munich	PROPN
fnp-8974	398	112	,	,	PUNCT
fnp-8974	398	113	munich	munich	PROPN
fnp-8974	398	114	,	,	PUNCT
fnp-8974	398	115	germany	germany	PROPN
fnp-8974	398	116	4	4	NUM
fnp-8974	398	117	institute	institute	PROPN
fnp-8974	398	118	of	of	ADP
fnp-8974	398	119	neuropathology	neuropathology	NOUN
fnp-8974	398	120	,	,	PUNCT
fnp-8974	398	121	university	university	NOUN
fnp-8974	398	122	hospital	hospital	NOUN
fnp-8974	398	123	münster	münster	NOUN
fnp-8974	398	124	,	,	PUNCT
fnp-8974	398	125	münster	münster	PROPN
fnp-8974	398	126	,	,	PUNCT
fnp-8974	398	127	germany	germany	PROPN
fnp-8974	398	128	5	5	NUM
fnp-8974	398	129	mildred	mildred	PROPN
fnp-8974	398	130	scheel	scheel	PROPN
fnp-8974	398	131	cancer	cancer	NOUN
fnp-8974	398	132	career	career	NOUN
fnp-8974	398	133	center	center	NOUN
fnp-8974	398	134	hatrics4	hatrics4	NOUN
fnp-8974	398	135	,	,	PUNCT
fnp-8974	398	136	university	university	NOUN
fnp-8974	398	137	medical	medical	ADJ
fnp-8974	398	138	center	center	PROPN
fnp-8974	398	139	hamburg	hamburg	PROPN
fnp-8974	398	140	-	-	PUNCT
fnp-8974	398	141	eppendorf	eppendorf	PROPN
fnp-8974	398	142	,	,	PUNCT
fnp-8974	398	143	hamburg	hamburg	PROPN
fnp-8974	398	144	,	,	PUNCT
fnp-8974	398	145	germany	germany	PROPN
fnp-8974	398	146	6	6	NUM
fnp-8974	398	147	department	department	NOUN
fnp-8974	398	148	of	of	ADP
fnp-8974	398	149	pediatric	pediatric	ADJ
fnp-8974	398	150	hematology	hematology	NOUN
fnp-8974	398	151	and	and	CCONJ
fnp-8974	398	152	oncology	oncology	NOUN
fnp-8974	398	153	,	,	PUNCT
fnp-8974	398	154	university	university	NOUN
fnp-8974	398	155	medical	medical	ADJ
fnp-8974	398	156	center	center	PROPN
fnp-8974	398	157	hamburg	hamburg	PROPN
fnp-8974	398	158	-	-	PUNCT
fnp-8974	398	159	eppendorf	eppendorf	PROPN
fnp-8974	398	160	,	,	PUNCT
fnp-8974	398	161	hamburg	hamburg	PROPN
fnp-8974	398	162	,	,	PUNCT
fnp-8974	398	163	germany	germany	PROPN
fnp-8974	398	164	7	7	NUM
fnp-8974	398	165	department	department	NOUN
fnp-8974	398	166	of	of	ADP
fnp-8974	398	167	oral	oral	ADJ
fnp-8974	398	168	and	and	CCONJ
fnp-8974	398	169	maxillofacial	maxillofacial	ADJ
fnp-8974	398	170	surgery	surgery	NOUN
fnp-8974	398	171	,	,	PUNCT
fnp-8974	398	172	university	university	NOUN
fnp-8974	398	173	medical	medical	ADJ
fnp-8974	398	174	center	center	PROPN
fnp-8974	398	175	hamburg	hamburg	PROPN
fnp-8974	398	176	-	-	PUNCT
fnp-8974	398	177	eppendorf	eppendorf	PROPN
fnp-8974	398	178	,	,	PUNCT
fnp-8974	398	179	hamburg	hamburg	PROPN
fnp-8974	398	180	,	,	PUNCT
fnp-8974	398	181	germany	germany	PROPN
fnp-8974	398	182	8	8	NUM
fnp-8974	398	183	department	department	PROPN
fnp-8974	398	184	of	of	ADP
fnp-8974	398	185	neurology	neurology	NOUN
fnp-8974	398	186	,	,	PUNCT
fnp-8974	398	187	university	university	NOUN
fnp-8974	398	188	medical	medical	ADJ
fnp-8974	398	189	center	center	PROPN
fnp-8974	398	190	hamburg	hamburg	PROPN
fnp-8974	398	191	-	-	PUNCT
fnp-8974	398	192	eppendorf	eppendorf	PROPN
fnp-8974	398	193	,	,	PUNCT
fnp-8974	398	194	hamburg	hamburg	PROPN
fnp-8974	398	195	,	,	PUNCT
fnp-8974	398	196	germany	germany	PROPN
fnp-8974	398	197	9	9	NUM
fnp-8974	398	198	center	center	NOUN
fnp-8974	398	199	for	for	ADP
fnp-8974	398	200	neuropathology	neuropathology	NOUN
fnp-8974	398	201	and	and	CCONJ
fnp-8974	398	202	prion	prion	NOUN
fnp-8974	398	203	research	research	NOUN
fnp-8974	398	204	,	,	PUNCT
fnp-8974	398	205	ludwig	ludwig	PROPN
fnp-8974	398	206	-	-	PUNCT
fnp-8974	398	207	maximilians	maximilians	PROPN
fnp-8974	398	208	-	-	PUNCT
fnp-8974	398	209	university	university	NOUN
fnp-8974	398	210	,	,	PUNCT
fnp-8974	398	211	munich	munich	PROPN
fnp-8974	398	212	,	,	PUNCT
fnp-8974	398	213	germany	germany	PROPN
fnp-8974	398	214	10	10	NUM
fnp-8974	398	215	karl	karl	PROPN
fnp-8974	398	216	landsteiner	landsteiner	PROPN
fnp-8974	398	217	privatuniversität	privatuniversität	PROPN
fnp-8974	398	218	für	für	PROPN
fnp-8974	398	219	gesundheitswissenschaften	gesundheitswissenschaften	VERB
fnp-8974	398	220	,	,	PUNCT
fnp-8974	398	221	st	st	PROPN
fnp-8974	398	222	.	.	PROPN
fnp-8974	398	223	pölten	pölten	PROPN
fnp-8974	398	224	,	,	PUNCT
fnp-8974	398	225	austria	austria	PROPN
fnp-8974	398	226	11	11	NUM
fnp-8974	398	227	institute	institute	PROPN
fnp-8974	398	228	of	of	ADP
fnp-8974	398	229	neuropathology	neuropathology	NOUN
fnp-8974	398	230	,	,	PUNCT
fnp-8974	398	231	university	university	NOUN
fnp-8974	398	232	medical	medical	ADJ
fnp-8974	398	233	center	center	PROPN
fnp-8974	398	234	hamburg	hamburg	PROPN
fnp-8974	398	235	-	-	PUNCT
fnp-8974	398	236	eppendorf	eppendorf	PROPN
fnp-8974	398	237	,	,	PUNCT
fnp-8974	398	238	hamburg	hamburg	PROPN
fnp-8974	398	239	,	,	PUNCT
fnp-8974	398	240	germany	germany	PROPN
fnp-8974	398	241	12	12	NUM
fnp-8974	398	242	children	child	NOUN
fnp-8974	398	243	’s	’s	PART
fnp-8974	398	244	cancer	cancer	NOUN
fnp-8974	398	245	research	research	PROPN
fnp-8974	398	246	center	center	PROPN
fnp-8974	398	247	hamburg	hamburg	PROPN
fnp-8974	398	248	,	,	PUNCT
fnp-8974	398	249	hamburg	hamburg	PROPN
fnp-8974	398	250	,	,	PUNCT
fnp-8974	398	251	germany	germany	PROPN
fnp-8974	398	252	background	background	NOUN
fnp-8974	398	253	:	:	PUNCT
fnp-8974	398	254	ependymomas	ependymomas	PROPN
fnp-8974	398	255	(	(	PUNCT
fnp-8974	398	256	epn	epn	PROPN
fnp-8974	398	257	)	)	PUNCT
fnp-8974	398	258	are	be	AUX
fnp-8974	398	259	heterogeneous	heterogeneous	ADJ
fnp-8974	398	260	tumours	tumour	NOUN
fnp-8974	398	261	occurring	occur	VERB
fnp-8974	398	262	across	across	ADP
fnp-8974	398	263	all	all	DET
fnp-8974	398	264	different	different	ADJ
fnp-8974	398	265	ages	age	NOUN
fnp-8974	398	266	and	and	CCONJ
fnp-8974	398	267	the	the	DET
fnp-8974	398	268	three	three	NUM
fnp-8974	398	269	major	major	ADJ
fnp-8974	398	270	compartments	compartment	NOUN
fnp-8974	398	271	of	of	ADP
fnp-8974	398	272	the	the	DET
fnp-8974	398	273	central	central	ADJ
fnp-8974	398	274	nervous	nervous	ADJ
fnp-8974	398	275	system	system	NOUN
fnp-8974	398	276	(	(	PUNCT
fnp-8974	398	277	spine	spine	NOUN
fnp-8974	398	278	(	(	PUNCT
fnp-8974	398	279	sp	sp	NOUN
fnp-8974	398	280	)	)	PUNCT
fnp-8974	398	281	,	,	PUNCT
fnp-8974	398	282	posterior	posterior	ADJ
fnp-8974	398	283	fossa	fossa	NOUN
fnp-8974	398	284	(	(	PUNCT
fnp-8974	398	285	pf	pf	NOUN
fnp-8974	398	286	)	)	PUNCT
fnp-8974	398	287	,	,	PUNCT
fnp-8974	398	288	supratentorial	supratentorial	ADJ
fnp-8974	398	289	(	(	PUNCT
fnp-8974	398	290	st	st	NOUN
fnp-8974	398	291	)	)	PUNCT
fnp-8974	398	292	)	)	PUNCT
fnp-8974	398	293	,	,	PUNCT
fnp-8974	398	294	being	be	AUX
fnp-8974	398	295	subdivided	subdivide	VERB
fnp-8974	398	296	into	into	ADP
fnp-8974	398	297	10	10	NUM
fnp-8974	398	298	molecular	molecular	ADJ
fnp-8974	398	299	types	type	NOUN
fnp-8974	398	300	(	(	PUNCT
fnp-8974	398	301	who	who	PRON
fnp-8974	398	302	2021	2021	NUM
fnp-8974	398	303	)	)	PUNCT
fnp-8974	398	304	,	,	PUNCT
fnp-8974	398	305	which	which	PRON
fnp-8974	398	306	display	display	VERB
fnp-8974	398	307	distinct	distinct	ADJ
fnp-8974	398	308	clinical	clinical	ADJ
fnp-8974	398	309	characteristics	characteristic	NOUN
fnp-8974	398	310	.	.	PUNCT
fnp-8974	399	1	objective(s	objective(s	NOUN
fnp-8974	399	2	):	):	PUNCT
fnp-8974	399	3	despite	despite	SCONJ
fnp-8974	399	4	advancements	advancement	NOUN
fnp-8974	399	5	in	in	ADP
fnp-8974	399	6	diagnostics	diagnostic	NOUN
fnp-8974	399	7	and	and	CCONJ
fnp-8974	399	8	tumour	tumour	NOUN
fnp-8974	399	9	characterisation	characterisation	NOUN
fnp-8974	399	10	,	,	PUNCT
fnp-8974	399	11	the	the	DET
fnp-8974	399	12	prognosis	prognosis	NOUN
fnp-8974	399	13	remains	remain	VERB
fnp-8974	399	14	variable	variable	ADJ
fnp-8974	399	15	and	and	CCONJ
fnp-8974	399	16	largely	largely	ADV
fnp-8974	399	17	dependent	dependent	ADJ
fnp-8974	399	18	on	on	ADP
fnp-8974	399	19	the	the	DET
fnp-8974	399	20	extent	extent	NOUN
fnp-8974	399	21	of	of	ADP
fnp-8974	399	22	tumour	tumour	ADJ
fnp-8974	399	23	resection	resection	NOUN
fnp-8974	399	24	.	.	PUNCT
fnp-8974	400	1	thus	thus	ADV
fnp-8974	400	2	,	,	PUNCT
fnp-8974	400	3	there	there	PRON
fnp-8974	400	4	is	be	VERB
fnp-8974	400	5	a	a	DET
fnp-8974	400	6	high	high	ADJ
fnp-8974	400	7	need	need	NOUN
fnp-8974	400	8	for	for	ADP
fnp-8974	400	9	targeted	target	VERB
fnp-8974	400	10	adjuvant	adjuvant	ADJ
fnp-8974	400	11	therapy	therapy	NOUN
fnp-8974	400	12	.	.	PUNCT
fnp-8974	401	1	through	through	ADP
fnp-8974	401	2	integrated	integrate	VERB
fnp-8974	401	3	proteomic	proteomic	ADJ
fnp-8974	401	4	analyses	analysis	NOUN
fnp-8974	401	5	,	,	PUNCT
fnp-8974	401	6	the	the	DET
fnp-8974	401	7	goal	goal	NOUN
fnp-8974	401	8	was	be	AUX
fnp-8974	401	9	to	to	PART
fnp-8974	401	10	identify	identify	VERB
fnp-8974	401	11	targetable	targetable	ADJ
fnp-8974	401	12	proteins	protein	NOUN
fnp-8974	401	13	and	and	CCONJ
fnp-8974	401	14	putative	putative	ADJ
fnp-8974	401	15	biomarkers	biomarker	NOUN
fnp-8974	401	16	for	for	ADP
fnp-8974	401	17	epn	epn	PROPN
fnp-8974	401	18	types	type	NOUN
fnp-8974	401	19	.	.	PUNCT
fnp-8974	402	1	method(s	method(	VERB
fnp-8974	402	2	):	):	PUNCT
fnp-8974	402	3	histomorphology	histomorphology	NOUN
fnp-8974	402	4	,	,	PUNCT
fnp-8974	402	5	dna	dna	PROPN
fnp-8974	402	6	-	-	PUNCT
fnp-8974	402	7	methylation-	methylation-	PROPN
fnp-8974	402	8	,	,	PUNCT
fnp-8974	402	9	proteomeand	proteomeand	NOUN
fnp-8974	402	10	phosphoproteome	phosphoproteome	ADJ
fnp-8974	402	11	data	datum	NOUN
fnp-8974	402	12	was	be	AUX
fnp-8974	402	13	assessed	assess	VERB
fnp-8974	402	14	from	from	ADP
fnp-8974	402	15	formalin	formalin	NOUN
fnp-8974	402	16	-	-	PUNCT
fnp-8974	402	17	fixed	fix	VERB
fnp-8974	402	18	paraffin	paraffin	NOUN
fnp-8974	402	19	-	-	PUNCT
fnp-8974	402	20	embedded	embed	VERB
fnp-8974	402	21	(	(	PUNCT
fnp-8974	402	22	ffpe	ffpe	NOUN
fnp-8974	402	23	)	)	PUNCT
fnp-8974	402	24	samples	sample	NOUN
fnp-8974	402	25	of	of	ADP
fnp-8974	402	26	primary	primary	ADJ
fnp-8974	402	27	human	human	ADJ
fnp-8974	402	28	epn	epn	PROPN
fnp-8974	402	29	.	.	PUNCT
fnp-8974	403	1	molecular	molecular	ADJ
fnp-8974	403	2	diagnosis	diagnosis	NOUN
fnp-8974	403	3	was	be	AUX
fnp-8974	403	4	verified	verify	VERB
fnp-8974	403	5	based	base	VERB
fnp-8974	403	6	on	on	ADP
fnp-8974	403	7	dna	dna	PROPN
fnp-8974	403	8	-	-	PUNCT
fnp-8974	403	9	methylation	methylation	NOUN
fnp-8974	403	10	data	datum	NOUN
fnp-8974	403	11	using	use	VERB
fnp-8974	403	12	the	the	DET
fnp-8974	403	13	brain	brain	NOUN
fnp-8974	403	14	tumour	tumour	NOUN
fnp-8974	403	15	classifier	classifier	NOUN
fnp-8974	403	16	(	(	PUNCT
fnp-8974	403	17	v12.8	v12.8	NUM
fnp-8974	403	18	,	,	PUNCT
fnp-8974	403	19	classifier	classifier	NOUN
fnp-8974	403	20	score	score	NOUN
fnp-8974	403	21	 	 	SPACE
fnp-8974	403	22	>	>	X
fnp-8974	403	23	 	 	SPACE
fnp-8974	403	24	0.8	0.8	NUM
fnp-8974	403	25	)	)	PUNCT
fnp-8974	403	26	.	.	PUNCT
fnp-8974	404	1	proteome	proteome	PROPN
fnp-8974	404	2	and	and	CCONJ
fnp-8974	404	3	phosphoproteome	phosphoproteome	PROPN
fnp-8974	404	4	data	datum	NOUN
fnp-8974	404	5	were	be	AUX
fnp-8974	404	6	generated	generate	VERB
fnp-8974	404	7	using	use	VERB
fnp-8974	404	8	mass	mass	ADJ
fnp-8974	404	9	spectrometry	spectrometry	NOUN
fnp-8974	404	10	.	.	PUNCT
fnp-8974	405	1	established	establish	VERB
fnp-8974	405	2	epigenomic	epigenomic	ADJ
fnp-8974	405	3	epn	epn	NOUN
fnp-8974	405	4	types	type	NOUN
fnp-8974	405	5	were	be	AUX
fnp-8974	405	6	reflected	reflect	VERB
fnp-8974	405	7	in	in	ADP
fnp-8974	405	8	our	our	PRON
fnp-8974	405	9	main	main	ADJ
fnp-8974	405	10	cohort	cohort	NOUN
fnp-8974	405	11	(	(	PUNCT
fnp-8974	405	12	n	n	CCONJ
fnp-8974	405	13	 	 	SPACE
fnp-8974	405	14	=	=	NOUN
fnp-8974	405	15	 	 	SPACE
fnp-8974	405	16	197	197	NUM
fnp-8974	405	17	epn	epn	NOUN
fnp-8974	405	18	with	with	ADP
fnp-8974	405	19	mpe	mpe	NOUN
fnp-8974	405	20	:	:	PUNCT
fnp-8974	405	21	n	n	CCONJ
fnp-8974	405	22	 	 	SPACE
fnp-8974	405	23	=	=	NOUN
fnp-8974	405	24	 	 	SPACE
fnp-8974	405	25	40	40	NUM
fnp-8974	405	26	,	,	PUNCT
fnp-8974	405	27	sp	sp	NOUN
fnp-8974	405	28	-	-	PUNCT
fnp-8974	405	29	epn	epn	NOUN
fnp-8974	405	30	:	:	PUNCT
fnp-8974	405	31	n	n	CCONJ
fnp-8974	405	32	 	 	SPACE
fnp-8974	405	33	=	=	NOUN
fnp-8974	405	34	 	 	SPACE
fnp-8974	405	35	31	31	NUM
fnp-8974	405	36	,	,	PUNCT
fnp-8974	405	37	sp	sp	NOUN
fnp-8974	405	38	-	-	PUNCT
fnp-8974	405	39	epn	epn	NOUN
fnp-8974	405	40	-	-	PUNCT
fnp-8974	405	41	mycn	mycn	NOUN
fnp-8974	405	42	:	:	PUNCT
fnp-8974	405	43	n	n	CCONJ
fnp-8974	405	44	 	 	SPACE
fnp-8974	405	45	=	=	NOUN
fnp-8974	405	46	 	 	SPACE
fnp-8974	405	47	9	9	NUM
fnp-8974	405	48	,	,	PUNCT
fnp-8974	405	49	sp	sp	NOUN
fnp-8974	405	50	-	-	PUNCT
fnp-8974	405	51	se	se	NOUN
fnp-8974	405	52	:	:	PUNCT
fnp-8974	405	53	n	n	CCONJ
fnp-8974	405	54	 	 	SPACE
fnp-8974	405	55	=	=	NOUN
fnp-8974	405	56	  	  	SPACE
fnp-8974	405	57	11	11	NUM
fnp-8974	405	58	,	,	PUNCT
fnp-8974	405	59	st	st	PROPN
fnp-8974	405	60	-	-	PUNCT
fnp-8974	405	61	se	se	NOUN
fnp-8974	405	62	:	:	PUNCT
fnp-8974	405	63	n	n	CCONJ
fnp-8974	405	64	 	 	SPACE
fnp-8974	405	65	=	=	NOUN
fnp-8974	405	66	 	 	SPACE
fnp-8974	405	67	16	16	NUM
fnp-8974	405	68	,	,	PUNCT
fnp-8974	405	69	pfa1	pfa1	PROPN
fnp-8974	405	70	:	:	PUNCT
fnp-8974	405	71	n	n	CCONJ
fnp-8974	405	72	 	 	SPACE
fnp-8974	405	73	=	=	NOUN
fnp-8974	405	74	 	 	SPACE
fnp-8974	405	75	14	14	NUM
fnp-8974	405	76	,	,	PUNCT
fnp-8974	405	77	pfa2	pfa2	NOUN
fnp-8974	405	78	:	:	PUNCT
fnp-8974	405	79	n	n	CCONJ
fnp-8974	405	80	 	 	SPACE
fnp-8974	405	81	=	=	NOUN
fnp-8974	405	82	 	 	SPACE
fnp-8974	405	83	5	5	NUM
fnp-8974	405	84	,	,	PUNCT
fnp-8974	405	85	pfb	pfb	NOUN
fnp-8974	405	86	:	:	PUNCT
fnp-8974	405	87	n	n	CCONJ
fnp-8974	405	88	 	 	SPACE
fnp-8974	405	89	=	=	NOUN
fnp-8974	405	90	 	 	SPACE
fnp-8974	405	91	19	19	NUM
fnp-8974	405	92	,	,	PUNCT
fnp-8974	405	93	pf	pf	PROPN
fnp-8974	405	94	-	-	PUNCT
fnp-8974	405	95	se	se	NOUN
fnp-8974	405	96	:	:	PUNCT
fnp-8974	405	97	n	n	CCONJ
fnp-8974	405	98	 	 	SPACE
fnp-8974	405	99	=	=	NOUN
fnp-8974	405	100	 	 	SPACE
fnp-8974	405	101	24	24	NUM
fnp-8974	405	102	,	,	PUNCT
fnp-8974	405	103	epn	epn	PROPN
fnp-8974	405	104	-	-	PUNCT
fnp-8974	405	105	yap	yap	NOUN
fnp-8974	405	106	:	:	PUNCT
fnp-8974	405	107	n	n	CCONJ
fnp-8974	405	108	 	 	SPACE
fnp-8974	405	109	=	=	NOUN
fnp-8974	405	110	 	 	SPACE
fnp-8974	405	111	6	6	NUM
fnp-8974	405	112	,	,	PUNCT
fnp-8974	405	113	epn	epn	NOUN
fnp-8974	405	114	-	-	PUNCT
fnp-8974	405	115	zfta	zfta	PROPN
fnp-8974	405	116	:	:	PUNCT
fnp-8974	405	117	n	n	CCONJ
fnp-8974	405	118	 	 	SPACE
fnp-8974	405	119	=	=	NOUN
fnp-8974	405	120	 	 	SPACE
fnp-8974	405	121	22	22	NUM
fnp-8974	405	122	)	)	PUNCT
fnp-8974	405	123	.	.	PUNCT
fnp-8974	406	1	result(s	result(s	PROPN
fnp-8974	406	2	):	):	PUNCT
fnp-8974	406	3	snf	snf	PROPN
fnp-8974	406	4	clustering	cluster	VERB
fnp-8974	406	5	integrating	integrate	VERB
fnp-8974	406	6	methylome	methylome	PROPN
fnp-8974	406	7	and	and	CCONJ
fnp-8974	406	8	proteome	proteome	PROPN
fnp-8974	406	9	data	datum	NOUN
fnp-8974	406	10	revealed	reveal	VERB
fnp-8974	406	11	stable	stable	ADJ
fnp-8974	406	12	clustering	clustering	NOUN
fnp-8974	406	13	of	of	ADP
fnp-8974	406	14	epn	epn	PROPN
fnp-8974	406	15	types	type	NOUN
fnp-8974	406	16	across	across	ADP
fnp-8974	406	17	data	datum	NOUN
fnp-8974	406	18	modalities	modality	NOUN
fnp-8974	406	19	.	.	PUNCT
fnp-8974	407	1	epn	epn	NOUN
fnp-8974	407	2	types	type	NOUN
fnp-8974	407	3	displayed	display	VERB
fnp-8974	407	4	distinct	distinct	ADJ
fnp-8974	407	5	protein	protein	NOUN
fnp-8974	407	6	patterns	pattern	NOUN
fnp-8974	407	7	allowing	allow	VERB
fnp-8974	407	8	for	for	ADP
fnp-8974	407	9	detection	detection	NOUN
fnp-8974	407	10	of	of	ADP
fnp-8974	407	11	putative	putative	ADJ
fnp-8974	407	12	markers	marker	NOUN
fnp-8974	407	13	and	and	CCONJ
fnp-8974	407	14	targetable	targetable	ADJ
fnp-8974	407	15	proteins	protein	NOUN
fnp-8974	407	16	.	.	PUNCT
fnp-8974	408	1	results	result	NOUN
fnp-8974	408	2	were	be	AUX
fnp-8974	408	3	confirmed	confirm	VERB
fnp-8974	408	4	in	in	ADP
fnp-8974	408	5	a	a	DET
fnp-8974	408	6	validation	validation	NOUN
fnp-8974	408	7	cohort	cohort	NOUN
fnp-8974	408	8	(	(	PUNCT
fnp-8974	408	9	n	n	CCONJ
fnp-8974	408	10	 	 	SPACE
fnp-8974	408	11	=	=	NOUN
fnp-8974	408	12	 	 	SPACE
fnp-8974	408	13	73	73	NUM
fnp-8974	408	14	)	)	PUNCT
fnp-8974	408	15	.	.	PUNCT
fnp-8974	409	1	in	in	ADP
fnp-8974	409	2	-	-	PUNCT
fnp-8974	409	3	depth	depth	NOUN
fnp-8974	409	4	integrative	integrative	ADJ
fnp-8974	409	5	analyses	analysis	NOUN
fnp-8974	409	6	are	be	AUX
fnp-8974	409	7	ongoing	ongoing	ADJ
fnp-8974	409	8	and	and	CCONJ
fnp-8974	409	9	will	will	AUX
fnp-8974	409	10	help	help	VERB
fnp-8974	409	11	to	to	PART
fnp-8974	409	12	identify	identify	VERB
fnp-8974	409	13	epn	epn	PROPN
fnp-8974	409	14	type	type	NOUN
fnp-8974	409	15	specific	specific	ADJ
fnp-8974	409	16	dysregulated	dysregulated	ADJ
fnp-8974	409	17	biological	biological	ADJ
fnp-8974	409	18	pathways	pathway	NOUN
fnp-8974	409	19	,	,	PUNCT
fnp-8974	409	20	biomarkers	biomarker	NOUN
fnp-8974	409	21	and	and	CCONJ
fnp-8974	409	22	treatment	treatment	NOUN
fnp-8974	409	23	targets	target	NOUN
fnp-8974	409	24	.	.	PUNCT
fnp-8974	410	1	conclusion(s	conclusion(s	NOUN
fnp-8974	410	2	):	):	PUNCT
fnp-8974	410	3	epn	epn	PROPN
fnp-8974	410	4	types	type	NOUN
fnp-8974	410	5	displayed	display	VERB
fnp-8974	410	6	distinct	distinct	ADJ
fnp-8974	410	7	protein	protein	NOUN
fnp-8974	410	8	patterns	pattern	NOUN
fnp-8974	410	9	allowing	allow	VERB
fnp-8974	410	10	for	for	ADP
fnp-8974	410	11	detection	detection	NOUN
fnp-8974	410	12	of	of	ADP
fnp-8974	410	13	putative	putative	ADJ
fnp-8974	410	14	markers	marker	NOUN
fnp-8974	410	15	and	and	CCONJ
fnp-8974	410	16	targetable	targetable	ADJ
fnp-8974	410	17	proteins	protein	NOUN
fnp-8974	410	18	.	.	PUNCT
fnp-8974	411	1	preliminary	preliminary	ADJ
fnp-8974	411	2	findings	finding	NOUN
fnp-8974	411	3	of	of	ADP
fnp-8974	411	4	the	the	DET
fnp-8974	411	5	phosphoproteome	phosphoproteome	ADJ
fnp-8974	411	6	analysis	analysis	NOUN
fnp-8974	411	7	showed	show	VERB
fnp-8974	411	8	high	high	ADJ
fnp-8974	411	9	epn	epn	PROPN
fnp-8974	411	10	heterogeneity	heterogeneity	NOUN
fnp-8974	411	11	and	and	CCONJ
fnp-8974	411	12	overlap	overlap	NOUN
fnp-8974	411	13	with	with	ADP
fnp-8974	411	14	known	know	VERB
fnp-8974	411	15	subtypes	subtype	NOUN
fnp-8974	411	16	.	.	PUNCT
fnp-8974	412	1	p32	p32	ADJ
fnp-8974	412	2	free	free	ADJ
fnp-8974	412	3	neuropathol	neuropathol	NOUN
fnp-8974	413	1	6:17:49	6:17:49	NUM
fnp-8974	413	2	identification	identification	NOUN
fnp-8974	413	3	of	of	ADP
fnp-8974	413	4	a	a	DET
fnp-8974	413	5	novel	novel	ADJ
fnp-8974	413	6	type	type	NOUN
fnp-8974	413	7	of	of	ADP
fnp-8974	413	8	pineal	pineal	ADJ
fnp-8974	413	9	region	region	NOUN
fnp-8974	413	10	tumors	tumor	NOUN
fnp-8974	413	11	with	with	ADP
fnp-8974	413	12	distinct	distinct	ADJ
fnp-8974	413	13	global	global	ADJ
fnp-8974	413	14	dna	dna	PROPN
fnp-8974	413	15	methylation	methylation	NOUN
fnp-8974	413	16	and	and	CCONJ
fnp-8974	413	17	sh3tc2	sh3tc2	NOUN
fnp-8974	413	18	fusions	fusion	NOUN
fnp-8974	413	19	abigail	abigail	PROPN
fnp-8974	413	20	suwala1,2	suwala1,2	PROPN
fnp-8974	413	21	,	,	PUNCT
fnp-8974	413	22	helena	helena	PROPN
fnp-8974	413	23	bode3,4,5,6	bode3,4,5,6	PROPN
fnp-8974	413	24	,	,	PUNCT
fnp-8974	413	25	lea	lea	PROPN
fnp-8974	413	26	altendorf3,4	altendorf3,4	PROPN
fnp-8974	413	27	,	,	PUNCT
fnp-8974	413	28	karoline	karoline	PROPN
fnp-8974	413	29	hack3,4	hack3,4	PROPN
fnp-8974	413	30	,	,	PUNCT
fnp-8974	413	31	alicia	alicia	PROPN
fnp-8974	413	32	fürst3,4	fürst3,4	PROPN
fnp-8974	413	33	,	,	PUNCT
fnp-8974	413	34	neal	neal	PROPN
fnp-8974	413	35	geisemeyer5	geisemeyer5	PROPN
fnp-8974	413	36	,	,	PUNCT
fnp-8974	413	37	alexandre	alexandre	PROPN
fnp-8974	413	38	vasiljevic7	vasiljevic7	PROPN
fnp-8974	413	39	,	,	PUNCT
fnp-8974	413	40	caterina	caterina	PROPN
fnp-8974	413	41	giannini8,9	giannini8,9	PROPN
fnp-8974	413	42	,	,	PUNCT
fnp-8974	413	43	ziedulla	ziedulla	PROPN
fnp-8974	413	44	abdullaev10	abdullaev10	PROPN
fnp-8974	413	45	,	,	PUNCT
fnp-8974	413	46	sebastian	sebastian	ADJ
fnp-8974	413	47	brandner11	brandner11	NOUN
fnp-8974	413	48	,	,	PUNCT
fnp-8974	413	49	jan	jan	PROPN
fnp-8974	413	50	beckervordersandforth12,13	beckervordersandforth12,13	PROPN
fnp-8974	413	51	,	,	PUNCT
fnp-8974	413	52	matija	matija	NOUN
fnp-8974	413	53	snuderl14	snuderl14	PROPN
fnp-8974	413	54	,	,	PUNCT
fnp-8974	413	55	josefine	josefine	PROPN
fnp-8974	413	56	radke15,16	radke15,16	PROPN
fnp-8974	413	57	,	,	PUNCT
fnp-8974	413	58	carlos	carlos	PROPN
fnp-8974	413	59	rodríguez	rodríguez	VERB
fnp-8974	413	60	antolín17,18	antolín17,18	PROPN
fnp-8974	413	61	,	,	PUNCT
fnp-8974	413	62	lindsey	lindsey	NOUN
fnp-8974	413	63	lowder19	lowder19	PROPN
fnp-8974	413	64	,	,	PUNCT
fnp-8974	413	65	aaron	aaron	PROPN
fnp-8974	413	66	mammoser20	mammoser20	PROPN
fnp-8974	413	67	,	,	PUNCT
fnp-8974	413	68	tyler	tyler	PROPN
fnp-8974	413	69	j.	j.	PROPN
fnp-8974	413	70	kenning21	kenning21	PROPN
fnp-8974	413	71	,	,	PUNCT
fnp-8974	413	72	christian	christian	PROPN
fnp-8974	413	73	thomas22	thomas22	PROPN
fnp-8974	413	74	,	,	PUNCT
fnp-8974	413	75	martin	martin	PROPN
fnp-8974	413	76	hasselblatt22	hasselblatt22	PROPN
fnp-8974	413	77	,	,	PUNCT
fnp-8974	413	78	kay	kay	PROPN
fnp-8974	413	79	hertel23	hertel23	PROPN
fnp-8974	413	80	,	,	PUNCT
fnp-8974	413	81	michael	michael	PROPN
fnp-8974	413	82	brodhun23,24	brodhun23,24	PROPN
fnp-8974	413	83	,	,	PUNCT
fnp-8974	413	84	quynh	quynh	PROPN
fnp-8974	413	85	nhu	nhu	PROPN
fnp-8974	413	86	nguyen1,2	nguyen1,2	PROPN
fnp-8974	413	87	,	,	PUNCT
fnp-8974	413	88	andreas	andreas	PROPN
fnp-8974	413	89	von	von	PROPN
fnp-8974	413	90	deimling1,2	deimling1,2	PROPN
fnp-8974	413	91	,	,	PUNCT
fnp-8974	413	92	stefan	stefan	PROPN
fnp-8974	413	93	pfister5,6,25,26	pfister5,6,25,26	PROPN
fnp-8974	413	94	,	,	PUNCT
fnp-8974	413	95	brian	brian	PROPN
fnp-8974	413	96	gudenas27	gudenas27	PROPN
fnp-8974	413	97	,	,	PUNCT
fnp-8974	413	98	paul	paul	PROPN
fnp-8974	413	99	northcott27	northcott27	PROPN
fnp-8974	413	100	,	,	PUNCT
fnp-8974	413	101	felix	felix	PROPN
fnp-8974	413	102	sahm15	sahm15	NOUN
fnp-8974	413	103	,	,	PUNCT
fnp-8974	413	104	marcel	marcel	PROPN
fnp-8974	413	105	kool5,28	kool5,28	PROPN
fnp-8974	413	106	,	,	PUNCT
fnp-8974	413	107	ulrich	ulrich	PROPN
fnp-8974	413	108	schüller3,4,29	schüller3,4,29	PROPN
fnp-8974	413	109	1	1	NUM
fnp-8974	413	110	department	department	NOUN
fnp-8974	413	111	of	of	ADP
fnp-8974	413	112	neuropathology	neuropathology	NOUN
fnp-8974	413	113	,	,	PUNCT
fnp-8974	413	114	institute	institute	PROPN
fnp-8974	413	115	of	of	ADP
fnp-8974	413	116	pathology	pathology	PROPN
fnp-8974	413	117	,	,	PUNCT
fnp-8974	413	118	university	university	PROPN
fnp-8974	413	119	of	of	ADP
fnp-8974	413	120	heidelberg	heidelberg	PROPN
fnp-8974	413	121	,	,	PUNCT
fnp-8974	413	122	heidelberg	heidelberg	PROPN
fnp-8974	413	123	,	,	PUNCT
fnp-8974	413	124	germany	germany	PROPN
fnp-8974	413	125	2	2	NUM
fnp-8974	413	126	clinical	clinical	ADJ
fnp-8974	413	127	cooperation	cooperation	NOUN
fnp-8974	413	128	unit	unit	NOUN
fnp-8974	413	129	neuropathology	neuropathology	NOUN
fnp-8974	413	130	,	,	PUNCT
fnp-8974	413	131	german	german	ADJ
fnp-8974	413	132	cancer	cancer	NOUN
fnp-8974	413	133	research	research	NOUN
fnp-8974	413	134	center	center	NOUN
fnp-8974	413	135	(	(	PUNCT
fnp-8974	413	136	dkfz	dkfz	PROPN
fnp-8974	413	137	)	)	PUNCT
fnp-8974	413	138	,	,	PUNCT
fnp-8974	413	139	german	german	ADJ
fnp-8974	413	140	consortium	consortium	NOUN
fnp-8974	413	141	for	for	ADP
fnp-8974	413	142	translational	translational	ADJ
fnp-8974	413	143	cancer	cancer	NOUN
fnp-8974	413	144	research	research	NOUN
fnp-8974	413	145	(	(	PUNCT
fnp-8974	413	146	dktk	dktk	NOUN
fnp-8974	413	147	)	)	PUNCT
fnp-8974	413	148	,	,	PUNCT
fnp-8974	413	149	heidelberg	heidelberg	PROPN
fnp-8974	413	150	,	,	PUNCT
fnp-8974	413	151	germany	germany	PROPN
fnp-8974	413	152	3	3	NUM
fnp-8974	413	153	research	research	PROPN
fnp-8974	413	154	institute	institute	PROPN
fnp-8974	413	155	children	child	NOUN
fnp-8974	413	156	’s	’s	PART
fnp-8974	413	157	cancer	cancer	NOUN
fnp-8974	413	158	center	center	PROPN
fnp-8974	413	159	hamburg	hamburg	PROPN
fnp-8974	413	160	,	,	PUNCT
fnp-8974	413	161	hamburg	hamburg	PROPN
fnp-8974	413	162	,	,	PUNCT
fnp-8974	413	163	germany	germany	PROPN
fnp-8974	413	164	4	4	NUM
fnp-8974	413	165	pediatric	pediatric	ADJ
fnp-8974	413	166	hematology	hematology	NOUN
fnp-8974	413	167	and	and	CCONJ
fnp-8974	413	168	oncology	oncology	NOUN
fnp-8974	413	169	,	,	PUNCT
fnp-8974	413	170	university	university	NOUN
fnp-8974	413	171	medical	medical	ADJ
fnp-8974	413	172	center	center	PROPN
fnp-8974	413	173	hamburg	hamburg	PROPN
fnp-8974	413	174	-	-	PUNCT
fnp-8974	413	175	eppendorf	eppendorf	PROPN
fnp-8974	413	176	,	,	PUNCT
fnp-8974	413	177	hamburg	hamburg	PROPN
fnp-8974	413	178	,	,	PUNCT
fnp-8974	413	179	germany	germany	PROPN
fnp-8974	413	180	5	5	NUM
fnp-8974	413	181	hopp	hopp	PROPN
fnp-8974	413	182	children	children	PROPN
fnp-8974	413	183	’s	’s	PART
fnp-8974	413	184	cancer	cancer	NOUN
fnp-8974	413	185	center	center	PROPN
fnp-8974	413	186	heidelberg	heidelberg	PROPN
fnp-8974	413	187	(	(	PUNCT
fnp-8974	413	188	kitz	kitz	PROPN
fnp-8974	413	189	)	)	PUNCT
fnp-8974	413	190	,	,	PUNCT
fnp-8974	413	191	heidelberg	heidelberg	PROPN
fnp-8974	413	192	,	,	PUNCT
fnp-8974	413	193	germany	germany	PROPN
fnp-8974	413	194	6	6	NUM
fnp-8974	413	195	division	division	NOUN
fnp-8974	413	196	of	of	ADP
fnp-8974	413	197	pediatric	pediatric	ADJ
fnp-8974	413	198	neurooncology	neurooncology	NOUN
fnp-8974	413	199	,	,	PUNCT
fnp-8974	413	200	german	german	ADJ
fnp-8974	413	201	cancer	cancer	NOUN
fnp-8974	413	202	consortium	consortium	NOUN
fnp-8974	413	203	(	(	PUNCT
fnp-8974	413	204	dktk	dktk	NOUN
fnp-8974	413	205	)	)	PUNCT
fnp-8974	413	206	and	and	CCONJ
fnp-8974	413	207	german	german	ADJ
fnp-8974	413	208	cancer	cancer	NOUN
fnp-8974	413	209	research	research	NOUN
fnp-8974	413	210	center	center	NOUN
fnp-8974	413	211	(	(	PUNCT
fnp-8974	413	212	dkfz	dkfz	PROPN
fnp-8974	413	213	)	)	PUNCT
fnp-8974	413	214	,	,	PUNCT
fnp-8974	413	215	heidelberg	heidelberg	PROPN
fnp-8974	413	216	,	,	PUNCT
fnp-8974	413	217	germany	germany	PROPN
fnp-8974	413	218	7	7	NUM
fnp-8974	413	219	centre	centre	PROPN
fnp-8974	413	220	de	de	X
fnp-8974	413	221	pathologie	pathologie	X
fnp-8974	413	222	et	et	PROPN
fnp-8974	413	223	neuropathologie	neuropathologie	PROPN
fnp-8974	413	224	est	est	PROPN
fnp-8974	413	225	,	,	PUNCT
fnp-8974	413	226	centre	centre	PROPN
fnp-8974	413	227	de	de	X
fnp-8974	413	228	biologie	biologie	X
fnp-8974	413	229	et	et	PROPN
fnp-8974	413	230	pathologie	pathologie	PROPN
fnp-8974	413	231	est	est	PROPN
fnp-8974	413	232	,	,	PUNCT
fnp-8974	413	233	groupement	groupement	PROPN
fnp-8974	413	234	hospitalier	hospitalier	PROPN
fnp-8974	413	235	est	est	X
fnp-8974	413	236	,	,	PUNCT
fnp-8974	413	237	hospices	hospice	VERB
fnp-8974	413	238	civils	civils	PROPN
fnp-8974	413	239	de	de	PROPN
fnp-8974	413	240	lyon	lyon	PROPN
fnp-8974	413	241	,	,	PUNCT
fnp-8974	413	242	bron	bron	PROPN
fnp-8974	413	243	,	,	PUNCT
fnp-8974	413	244	france	france	PROPN
fnp-8974	413	245	8	8	NUM
fnp-8974	413	246	department	department	NOUN
fnp-8974	413	247	of	of	ADP
fnp-8974	413	248	laboratory	laboratory	NOUN
fnp-8974	413	249	medicine	medicine	NOUN
fnp-8974	413	250	and	and	CCONJ
fnp-8974	413	251	pathology	pathology	NOUN
fnp-8974	413	252	,	,	PUNCT
fnp-8974	413	253	mayo	mayo	NOUN
fnp-8974	413	254	clinic	clinic	PROPN
fnp-8974	413	255	,	,	PUNCT
fnp-8974	413	256	rochester	rochester	PROPN
fnp-8974	413	257	,	,	PUNCT
fnp-8974	413	258	minnesota	minnesota	PROPN
fnp-8974	413	259	,	,	PUNCT
fnp-8974	413	260	united	united	PROPN
fnp-8974	413	261	states	states	PROPN
fnp-8974	413	262	9	9	NUM
fnp-8974	413	263	department	department	NOUN
fnp-8974	413	264	of	of	ADP
fnp-8974	413	265	biomedical	biomedical	ADJ
fnp-8974	413	266	and	and	CCONJ
fnp-8974	413	267	neuromotor	neuromotor	NOUN
fnp-8974	413	268	sciences	sciences	PROPN
fnp-8974	413	269	(	(	PUNCT
fnp-8974	413	270	dibinem	dibinem	PROPN
fnp-8974	413	271	)	)	PUNCT
fnp-8974	413	272	,	,	PUNCT
fnp-8974	413	273	alma	alma	NOUN
fnp-8974	413	274	mater	mater	PROPN
fnp-8974	413	275	studiorum	studiorum	PROPN
fnp-8974	413	276	,	,	PUNCT
fnp-8974	413	277	bologna	bologna	PROPN
fnp-8974	413	278	,	,	PUNCT
fnp-8974	413	279	italy	italy	PROPN
fnp-8974	413	280	10	10	NUM
fnp-8974	413	281	laboratory	laboratory	NOUN
fnp-8974	413	282	of	of	ADP
fnp-8974	413	283	pathology	pathology	PROPN
fnp-8974	413	284	clinical	clinical	ADJ
fnp-8974	413	285	methylation	methylation	NOUN
fnp-8974	413	286	unit	unit	NOUN
fnp-8974	413	287	,	,	PUNCT
fnp-8974	413	288	center	center	NOUN
fnp-8974	413	289	for	for	ADP
fnp-8974	413	290	cancer	cancer	NOUN
fnp-8974	413	291	research	research	NOUN
fnp-8974	413	292	,	,	PUNCT
fnp-8974	413	293	national	national	PROPN
fnp-8974	413	294	cancer	cancer	PROPN
fnp-8974	413	295	institute	institute	PROPN
fnp-8974	413	296	,	,	PUNCT
fnp-8974	413	297	bethesda	bethesda	PROPN
fnp-8974	413	298	,	,	PUNCT
fnp-8974	413	299	maryland	maryland	PROPN
fnp-8974	413	300	,	,	PUNCT
fnp-8974	413	301	united	united	PROPN
fnp-8974	413	302	states	states	PROPN
fnp-8974	413	303	11	11	NUM
fnp-8974	413	304	department	department	NOUN
fnp-8974	413	305	of	of	ADP
fnp-8974	413	306	neurodegenerative	neurodegenerative	ADJ
fnp-8974	413	307	disease	disease	NOUN
fnp-8974	413	308	,	,	PUNCT
fnp-8974	413	309	ucl	ucl	PROPN
fnp-8974	413	310	queen	queen	PROPN
fnp-8974	413	311	square	square	PROPN
fnp-8974	413	312	institute	institute	PROPN
fnp-8974	413	313	of	of	ADP
fnp-8974	413	314	neurology	neurology	NOUN
fnp-8974	413	315	and	and	CCONJ
fnp-8974	413	316	division	division	NOUN
fnp-8974	413	317	of	of	ADP
fnp-8974	413	318	neuropathology	neuropathology	NOUN
fnp-8974	413	319	,	,	PUNCT
fnp-8974	413	320	university	university	NOUN
fnp-8974	413	321	college	college	NOUN
fnp-8974	413	322	london	london	PROPN
fnp-8974	413	323	hospitals	hospital	NOUN
fnp-8974	413	324	nhs	nhs	PROPN
fnp-8974	413	325	foundation	foundation	PROPN
fnp-8974	413	326	trust	trust	PROPN
fnp-8974	413	327	,	,	PUNCT
fnp-8974	413	328	london	london	PROPN
fnp-8974	413	329	,	,	PUNCT
fnp-8974	413	330	united	united	PROPN
fnp-8974	413	331	kingdom	kingdom	PROPN
fnp-8974	413	332	12	12	NUM
fnp-8974	413	333	grow	grow	NOUN
fnp-8974	413	334	-	-	PUNCT
fnp-8974	413	335	school	school	NOUN
fnp-8974	413	336	for	for	ADP
fnp-8974	413	337	oncology	oncology	NOUN
fnp-8974	413	338	and	and	CCONJ
fnp-8974	413	339	reproduction	reproduction	NOUN
fnp-8974	413	340	,	,	PUNCT
fnp-8974	413	341	maastricht	maastricht	PROPN
fnp-8974	413	342	university	university	PROPN
fnp-8974	413	343	,	,	PUNCT
fnp-8974	413	344	maastricht	maastricht	PROPN
fnp-8974	413	345	,	,	PUNCT
fnp-8974	413	346	netherlands	netherlands	PROPN
fnp-8974	413	347	13	13	NUM
fnp-8974	413	348	department	department	PROPN
fnp-8974	413	349	of	of	ADP
fnp-8974	413	350	pathology	pathology	PROPN
fnp-8974	413	351	,	,	PUNCT
fnp-8974	413	352	maastricht	maastricht	PROPN
fnp-8974	413	353	university	university	PROPN
fnp-8974	413	354	medical	medical	ADJ
fnp-8974	413	355	center	center	NOUN
fnp-8974	413	356	,	,	PUNCT
fnp-8974	413	357	maastricht	maastricht	PROPN
fnp-8974	413	358	,	,	PUNCT
fnp-8974	413	359	netherlands	netherlands	PROPN
fnp-8974	413	360	14	14	NUM
fnp-8974	413	361	department	department	PROPN
fnp-8974	413	362	of	of	ADP
fnp-8974	413	363	pathology	pathology	PROPN
fnp-8974	413	364	,	,	PUNCT
fnp-8974	413	365	new	new	PROPN
fnp-8974	413	366	york	york	PROPN
fnp-8974	413	367	university	university	PROPN
fnp-8974	413	368	langone	langone	NOUN
fnp-8974	413	369	health	health	NOUN
fnp-8974	413	370	,	,	PUNCT
fnp-8974	413	371	new	new	PROPN
fnp-8974	413	372	york	york	PROPN
fnp-8974	413	373	,	,	PUNCT
fnp-8974	413	374	united	united	PROPN
fnp-8974	413	375	states	states	PROPN
fnp-8974	413	376	15	15	NUM
fnp-8974	413	377	department	department	NOUN
fnp-8974	413	378	of	of	ADP
fnp-8974	413	379	pathology	pathology	PROPN
fnp-8974	413	380	,	,	PUNCT
fnp-8974	413	381	university	university	NOUN
fnp-8974	413	382	medicine	medicine	NOUN
fnp-8974	413	383	greifswald	greifswald	PROPN
fnp-8974	413	384	,	,	PUNCT
fnp-8974	413	385	greifswald	greifswald	PROPN
fnp-8974	413	386	,	,	PUNCT
fnp-8974	413	387	germany	germany	PROPN
fnp-8974	413	388	16	16	PROPN
fnp-8974	413	389	institute	institute	PROPN
fnp-8974	413	390	of	of	ADP
fnp-8974	413	391	molecular	molecular	ADJ
fnp-8974	413	392	genomics	genomic	NOUN
fnp-8974	413	393	,	,	PUNCT
fnp-8974	413	394	university	university	NOUN
fnp-8974	413	395	medicine	medicine	NOUN
fnp-8974	413	396	greifswald	greifswald	PROPN
fnp-8974	413	397	,	,	PUNCT
fnp-8974	413	398	greifswald	greifswald	PROPN
fnp-8974	413	399	,	,	PUNCT
fnp-8974	413	400	germany	germany	PROPN
fnp-8974	413	401	17	17	NUM
fnp-8974	413	402	cancer	cancer	NOUN
fnp-8974	413	403	epigenetics	epigenetic	NOUN
fnp-8974	413	404	laboratory	laboratory	NOUN
fnp-8974	413	405	,	,	PUNCT
fnp-8974	413	406	ingemm	ingemm	NOUN
fnp-8974	413	407	,	,	PUNCT
fnp-8974	413	408	la	la	PROPN
fnp-8974	413	409	paz	paz	PROPN
fnp-8974	413	410	university	university	NOUN
fnp-8974	413	411	hospital	hospital	NOUN
fnp-8974	413	412	,	,	PUNCT
fnp-8974	413	413	biomarkers	biomarker	NOUN
fnp-8974	413	414	and	and	CCONJ
fnp-8974	413	415	experimental	experimental	ADJ
fnp-8974	413	416	therapeutics	therapeutic	NOUN
fnp-8974	413	417	in	in	ADP
fnp-8974	413	418	cancer	cancer	NOUN
fnp-8974	413	419	,	,	PUNCT
fnp-8974	413	420	idipaz	idipaz	PROPN
fnp-8974	413	421	,	,	PUNCT
fnp-8974	413	422	madrid	madrid	PROPN
fnp-8974	413	423	,	,	PUNCT
fnp-8974	413	424	spain	spain	PROPN
fnp-8974	413	425	18	18	NUM
fnp-8974	413	426	bioinformatics	bioinformatic	NOUN
fnp-8974	413	427	unit	unit	NOUN
fnp-8974	413	428	,	,	PUNCT
fnp-8974	413	429	ingemm	ingemm	PROPN
fnp-8974	413	430	,	,	PUNCT
fnp-8974	413	431	la	la	PROPN
fnp-8974	413	432	paz	paz	PROPN
fnp-8974	413	433	university	university	NOUN
fnp-8974	413	434	hospital	hospital	NOUN
fnp-8974	413	435	,	,	PUNCT
fnp-8974	413	436	madrid	madrid	PROPN
fnp-8974	413	437	,	,	PUNCT
fnp-8974	413	438	spain	spain	PROPN
fnp-8974	413	439	19	19	NUM
fnp-8974	413	440	department	department	PROPN
fnp-8974	413	441	of	of	ADP
fnp-8974	413	442	pathology	pathology	NOUN
fnp-8974	413	443	and	and	CCONJ
fnp-8974	413	444	laboratory	laboratory	NOUN
fnp-8974	413	445	medicine	medicine	NOUN
fnp-8974	413	446	,	,	PUNCT
fnp-8974	413	447	emory	emory	PROPN
fnp-8974	413	448	university	university	PROPN
fnp-8974	413	449	school	school	NOUN
fnp-8974	413	450	of	of	ADP
fnp-8974	413	451	medicine	medicine	NOUN
fnp-8974	413	452	,	,	PUNCT
fnp-8974	413	453	atlanta	atlanta	PROPN
fnp-8974	413	454	,	,	PUNCT
fnp-8974	413	455	georgia	georgia	PROPN
fnp-8974	413	456	,	,	PUNCT
fnp-8974	413	457	united	united	PROPN
fnp-8974	413	458	states	states	PROPN
fnp-8974	413	459	20	20	NUM
fnp-8974	413	460	department	department	NOUN
fnp-8974	413	461	of	of	ADP
fnp-8974	413	462	neuroscience	neuroscience	NOUN
fnp-8974	413	463	and	and	CCONJ
fnp-8974	413	464	oncology	oncology	NOUN
fnp-8974	413	465	,	,	PUNCT
fnp-8974	413	466	piedmont	piedmont	PROPN
fnp-8974	413	467	brain	brain	PROPN
fnp-8974	413	468	tumor	tumor	PROPN
fnp-8974	413	469	center	center	NOUN
fnp-8974	413	470	,	,	PUNCT
fnp-8974	413	471	piedmont	piedmont	PROPN
fnp-8974	413	472	atlanta	atlanta	PROPN
fnp-8974	413	473	hospital	hospital	PROPN
fnp-8974	413	474	,	,	PUNCT
fnp-8974	413	475	atlanta	atlanta	PROPN
fnp-8974	413	476	,	,	PUNCT
fnp-8974	413	477	georgia	georgia	PROPN
fnp-8974	413	478	,	,	PUNCT
fnp-8974	413	479	united	united	PROPN
fnp-8974	413	480	states	states	PROPN
fnp-8974	413	481	21	21	NUM
fnp-8974	413	482	neurosurgery	neurosurgery	PROPN
fnp-8974	413	483	department	department	NOUN
fnp-8974	413	484	,	,	PUNCT
fnp-8974	413	485	piedmont	piedmont	PROPN
fnp-8974	413	486	atlanta	atlanta	PROPN
fnp-8974	413	487	hospital	hospital	PROPN
fnp-8974	413	488	,	,	PUNCT
fnp-8974	413	489	atlanta	atlanta	PROPN
fnp-8974	413	490	,	,	PUNCT
fnp-8974	413	491	georgia	georgia	PROPN
fnp-8974	413	492	,	,	PUNCT
fnp-8974	413	493	united	united	PROPN
fnp-8974	413	494	states	states	PROPN
fnp-8974	413	495	22	22	NUM
fnp-8974	413	496	institute	institute	PROPN
fnp-8974	413	497	of	of	ADP
fnp-8974	413	498	neuropathology	neuropathology	NOUN
fnp-8974	413	499	,	,	PUNCT
fnp-8974	413	500	university	university	NOUN
fnp-8974	413	501	hospital	hospital	NOUN
fnp-8974	413	502	münster	münster	NOUN
fnp-8974	413	503	,	,	PUNCT
fnp-8974	413	504	münster	münster	PROPN
fnp-8974	413	505	,	,	PUNCT
fnp-8974	413	506	germany	germany	PROPN
fnp-8974	413	507	23	23	NUM
fnp-8974	413	508	department	department	PROPN
fnp-8974	413	509	of	of	ADP
fnp-8974	413	510	pathology	pathology	PROPN
fnp-8974	413	511	and	and	CCONJ
fnp-8974	413	512	neuropathology	neuropathology	NOUN
fnp-8974	413	513	,	,	PUNCT
fnp-8974	413	514	helios	helios	PROPN
fnp-8974	413	515	clinic	clinic	NOUN
fnp-8974	413	516	erfurt	erfurt	PROPN
fnp-8974	413	517	,	,	PUNCT
fnp-8974	413	518	health	health	NOUN
fnp-8974	413	519	and	and	CCONJ
fnp-8974	413	520	medical	medical	ADJ
fnp-8974	413	521	university	university	NOUN
fnp-8974	413	522	,	,	PUNCT
fnp-8974	413	523	erfurt	erfurt	PROPN
fnp-8974	413	524	,	,	PUNCT
fnp-8974	413	525	germany	germany	PROPN
fnp-8974	413	526	24	24	NUM
fnp-8974	413	527	department	department	NOUN
fnp-8974	413	528	of	of	ADP
fnp-8974	413	529	neurosurgery	neurosurgery	NOUN
fnp-8974	413	530	,	,	PUNCT
fnp-8974	413	531	helios	helios	PROPN
fnp-8974	413	532	clinic	clinic	NOUN
fnp-8974	413	533	erfurt	erfurt	PROPN
fnp-8974	413	534	,	,	PUNCT
fnp-8974	413	535	health	health	NOUN
fnp-8974	413	536	and	and	CCONJ
fnp-8974	413	537	medical	medical	ADJ
fnp-8974	413	538	university	university	NOUN
fnp-8974	413	539	,	,	PUNCT
fnp-8974	413	540	erfurt	erfurt	PROPN
fnp-8974	413	541	,	,	PUNCT
fnp-8974	413	542	germany	germany	PROPN
fnp-8974	413	543	25	25	NUM
fnp-8974	413	544	department	department	NOUN
fnp-8974	413	545	of	of	ADP
fnp-8974	413	546	pediatric	pediatric	ADJ
fnp-8974	413	547	hematology	hematology	NOUN
fnp-8974	413	548	and	and	CCONJ
fnp-8974	413	549	oncology	oncology	NOUN
fnp-8974	413	550	,	,	PUNCT
fnp-8974	413	551	heidelberg	heidelberg	PROPN
fnp-8974	413	552	university	university	PROPN
fnp-8974	413	553	hospital	hospital	NOUN
fnp-8974	413	554	,	,	PUNCT
fnp-8974	413	555	heidelberg	heidelberg	PROPN
fnp-8974	413	556	,	,	PUNCT
fnp-8974	413	557	germany	germany	PROPN
fnp-8974	413	558	26	26	NUM
fnp-8974	413	559	national	national	ADJ
fnp-8974	413	560	center	center	NOUN
fnp-8974	413	561	for	for	ADP
fnp-8974	413	562	tumor	tumor	NOUN
fnp-8974	413	563	diseases	disease	NOUN
fnp-8974	413	564	(	(	PUNCT
fnp-8974	413	565	nct	nct	NOUN
fnp-8974	413	566	)	)	PUNCT
fnp-8974	413	567	,	,	PUNCT
fnp-8974	413	568	heidelberg	heidelberg	PROPN
fnp-8974	413	569	,	,	PUNCT
fnp-8974	413	570	germany	germany	PROPN
fnp-8974	413	571	27	27	NUM
fnp-8974	413	572	department	department	NOUN
fnp-8974	413	573	of	of	ADP
fnp-8974	413	574	developmental	developmental	ADJ
fnp-8974	413	575	neurobiology	neurobiology	NOUN
fnp-8974	413	576	,	,	PUNCT
fnp-8974	413	577	st	st	PROPN
fnp-8974	413	578	.	.	PROPN
fnp-8974	413	579	jude	jude	PROPN
fnp-8974	413	580	children	children	PROPN
fnp-8974	413	581	's	's	PART
fnp-8974	413	582	research	research	NOUN
fnp-8974	413	583	hospital	hospital	NOUN
fnp-8974	413	584	,	,	PUNCT
fnp-8974	413	585	memphis	memphis	PROPN
fnp-8974	413	586	,	,	PUNCT
fnp-8974	413	587	tennessee	tennessee	PROPN
fnp-8974	413	588	,	,	PUNCT
fnp-8974	413	589	united	united	PROPN
fnp-8974	413	590	states	states	PROPN
fnp-8974	413	591	28	28	NUM
fnp-8974	413	592	princess	princess	PROPN
fnp-8974	413	593	máxima	máxima	PROPN
fnp-8974	413	594	center	center	NOUN
fnp-8974	413	595	for	for	ADP
fnp-8974	413	596	pediatric	pediatric	ADJ
fnp-8974	413	597	oncology	oncology	NOUN
fnp-8974	413	598	,	,	PUNCT
fnp-8974	413	599	utrecht	utrecht	PROPN
fnp-8974	413	600	,	,	PUNCT
fnp-8974	413	601	netherlands	netherlands	PROPN
fnp-8974	413	602	29	29	NUM
fnp-8974	413	603	institute	institute	PROPN
fnp-8974	413	604	of	of	ADP
fnp-8974	413	605	neuropathology	neuropathology	NOUN
fnp-8974	413	606	,	,	PUNCT
fnp-8974	413	607	university	university	NOUN
fnp-8974	413	608	medical	medical	ADJ
fnp-8974	413	609	center	center	PROPN
fnp-8974	413	610	hamburg	hamburg	PROPN
fnp-8974	413	611	-	-	PUNCT
fnp-8974	413	612	eppendorf	eppendorf	PROPN
fnp-8974	413	613	,	,	PUNCT
fnp-8974	413	614	hamburg	hamburg	PROPN
fnp-8974	413	615	,	,	PUNCT
fnp-8974	413	616	germany	germany	PROPN
fnp-8974	413	617	pineal	pineal	NOUN
fnp-8974	413	618	tumors	tumor	NOUN
fnp-8974	413	619	are	be	AUX
fnp-8974	413	620	rare	rare	ADJ
fnp-8974	413	621	neoplasms	neoplasm	NOUN
fnp-8974	413	622	,	,	PUNCT
fnp-8974	413	623	accounting	account	VERB
fnp-8974	413	624	for	for	ADP
fnp-8974	413	625	less	less	ADJ
fnp-8974	413	626	than	than	ADP
fnp-8974	413	627	1	1	NUM
fnp-8974	413	628	 	 	SPACE
fnp-8974	413	629	%	%	NOUN
fnp-8974	413	630	of	of	ADP
fnp-8974	413	631	all	all	DET
fnp-8974	413	632	central	central	ADJ
fnp-8974	413	633	nervous	nervous	ADJ
fnp-8974	413	634	system	system	NOUN
fnp-8974	413	635	(	(	PUNCT
fnp-8974	413	636	cns	cns	NOUN
fnp-8974	413	637	)	)	PUNCT
fnp-8974	413	638	tumors	tumor	NOUN
fnp-8974	413	639	and	and	CCONJ
fnp-8974	413	640	occurring	occur	VERB
fnp-8974	413	641	primarily	primarily	ADV
fnp-8974	413	642	in	in	ADP
fnp-8974	413	643	adults	adult	NOUN
fnp-8974	413	644	.	.	PUNCT
fnp-8974	414	1	the	the	DET
fnp-8974	414	2	2021	2021	NUM
fnp-8974	414	3	world	world	PROPN
fnp-8974	414	4	health	health	NOUN
fnp-8974	414	5	organization	organization	NOUN
fnp-8974	414	6	(	(	PUNCT
fnp-8974	414	7	who	who	PRON
fnp-8974	414	8	)	)	PUNCT
fnp-8974	414	9	classification	classification	NOUN
fnp-8974	414	10	recognizes	recognize	VERB
fnp-8974	414	11	five	five	NUM
fnp-8974	414	12	distinct	distinct	ADJ
fnp-8974	414	13	tumor	tumor	NOUN
fnp-8974	414	14	entities	entity	NOUN
fnp-8974	414	15	of	of	ADP
fnp-8974	414	16	primary	primary	ADJ
fnp-8974	414	17	pineal	pineal	NOUN
fnp-8974	414	18	origin	origin	NOUN
fnp-8974	414	19	:	:	PUNCT
fnp-8974	414	20	pineocytoma	pineocytoma	NOUN
fnp-8974	414	21	;	;	PUNCT
fnp-8974	414	22	pineal	pineal	ADJ
fnp-8974	414	23	parenchymal	parenchymal	ADJ
fnp-8974	414	24	tumor	tumor	NOUN
fnp-8974	414	25	of	of	ADP
fnp-8974	414	26	intermediate	intermediate	ADJ
fnp-8974	414	27	differentiation	differentiation	NOUN
fnp-8974	414	28	(	(	PUNCT
fnp-8974	414	29	pptid	pptid	NOUN
fnp-8974	414	30	,	,	PUNCT
fnp-8974	414	31	with	with	ADP
fnp-8974	414	32	two	two	NUM
fnp-8974	414	33	molecular	molecular	ADJ
fnp-8974	414	34	subgroups	subgroup	NOUN
fnp-8974	414	35	)	)	PUNCT
fnp-8974	414	36	;	;	PUNCT
fnp-8974	414	37	pineoblastoma	pineoblastoma	NOUN
fnp-8974	414	38	(	(	PUNCT
fnp-8974	414	39	including	include	VERB
fnp-8974	414	40	four	four	NUM
fnp-8974	414	41	molecular	molecular	ADJ
fnp-8974	414	42	subgroups	subgroup	NOUN
fnp-8974	414	43	)	)	PUNCT
fnp-8974	414	44	;	;	PUNCT
fnp-8974	414	45	papillary	papillary	ADJ
fnp-8974	414	46	tumor	tumor	NOUN
fnp-8974	414	47	of	of	ADP
fnp-8974	414	48	the	the	DET
fnp-8974	414	49	pineal	pineal	NOUN
fnp-8974	414	50	region	region	NOUN
fnp-8974	414	51	(	(	PUNCT
fnp-8974	414	52	ptpr	ptpr	PROPN
fnp-8974	414	53	,	,	PUNCT
fnp-8974	414	54	with	with	ADP
fnp-8974	414	55	three	three	NUM
fnp-8974	414	56	molecular	molecular	ADJ
fnp-8974	414	57	subgroups	subgroup	NOUN
fnp-8974	414	58	)	)	PUNCT
fnp-8974	414	59	;	;	PUNCT
fnp-8974	414	60	and	and	CCONJ
fnp-8974	414	61	desmoplastic	desmoplastic	ADJ
fnp-8974	414	62	myxoid	myxoid	ADJ
fnp-8974	414	63	tumor	tumor	NOUN
fnp-8974	414	64	of	of	ADP
fnp-8974	414	65	the	the	DET
fnp-8974	414	66	pineal	pineal	NOUN
fnp-8974	414	67	region	region	NOUN
fnp-8974	414	68	,	,	PUNCT
fnp-8974	414	69	smarcb1	smarcb1	NOUN
fnp-8974	414	70	-	-	PUNCT
fnp-8974	414	71	mutant	mutant	NOUN
fnp-8974	414	72	.	.	PUNCT
fnp-8974	415	1	here	here	ADV
fnp-8974	415	2	,	,	PUNCT
fnp-8974	415	3	we	we	PRON
fnp-8974	415	4	describe	describe	VERB
fnp-8974	415	5	a	a	DET
fnp-8974	415	6	previously	previously	ADV
fnp-8974	415	7	unrecognized	unrecognize	VERB
fnp-8974	415	8	tumor	tumor	NOUN
fnp-8974	415	9	type	type	NOUN
fnp-8974	415	10	of	of	ADP
fnp-8974	415	11	the	the	DET
fnp-8974	415	12	pineal	pineal	NOUN
fnp-8974	415	13	region	region	NOUN
fnp-8974	415	14	(	(	PUNCT
fnp-8974	415	15	n	n	CCONJ
fnp-8974	415	16	 	 	SPACE
fnp-8974	415	17	=	=	NOUN
fnp-8974	415	18	 	 	SPACE
fnp-8974	415	19	27	27	NUM
fnp-8974	415	20	)	)	PUNCT
fnp-8974	415	21	characterized	characterize	VERB
fnp-8974	415	22	by	by	ADP
fnp-8974	415	23	a	a	DET
fnp-8974	415	24	unique	unique	ADJ
fnp-8974	415	25	and	and	CCONJ
fnp-8974	415	26	consistent	consistent	ADJ
fnp-8974	415	27	dna	dna	PROPN
fnp-8974	415	28	methylation	methylation	NOUN
fnp-8974	415	29	profile	profile	NOUN
fnp-8974	415	30	that	that	PRON
fnp-8974	415	31	does	do	AUX
fnp-8974	415	32	not	not	PART
fnp-8974	415	33	match	match	VERB
fnp-8974	415	34	any	any	DET
fnp-8974	415	35	known	know	VERB
fnp-8974	415	36	cns	cns	NOUN
fnp-8974	415	37	tumor	tumor	NOUN
fnp-8974	415	38	class	class	NOUN
fnp-8974	415	39	and	and	CCONJ
fnp-8974	415	40	is	be	AUX
fnp-8974	415	41	distinct	distinct	ADJ
fnp-8974	415	42	from	from	ADP
fnp-8974	415	43	all	all	DET
fnp-8974	415	44	currently	currently	ADV
fnp-8974	415	45	recognized	recognize	VERB
fnp-8974	415	46	pineal	pineal	ADJ
fnp-8974	415	47	tumor	tumor	NOUN
fnp-8974	415	48	entities	entity	NOUN
fnp-8974	415	49	.	.	PUNCT
fnp-8974	416	1	the	the	DET
fnp-8974	416	2	cohort	cohort	NOUN
fnp-8974	416	3	displayed	display	VERB
fnp-8974	416	4	a	a	DET
fnp-8974	416	5	balanced	balanced	ADJ
fnp-8974	416	6	sex	sex	NOUN
fnp-8974	416	7	distribution	distribution	NOUN
fnp-8974	416	8	,	,	PUNCT
fnp-8974	416	9	with	with	ADP
fnp-8974	416	10	a	a	DET
fnp-8974	416	11	mean	mean	ADJ
fnp-8974	416	12	patient	patient	ADJ
fnp-8974	416	13	age	age	NOUN
fnp-8974	416	14	of	of	ADP
fnp-8974	416	15	35	35	NUM
fnp-8974	416	16	years	year	NOUN
fnp-8974	416	17	(	(	PUNCT
fnp-8974	416	18	range	range	NOUN
fnp-8974	416	19	:	:	PUNCT
fnp-8974	416	20	7–74	7–74	ADJ
fnp-8974	416	21	years	year	NOUN
fnp-8974	416	22	)	)	PUNCT
fnp-8974	416	23	.	.	PUNCT
fnp-8974	417	1	histopathological	histopathological	ADJ
fnp-8974	417	2	analysis	analysis	NOUN
fnp-8974	417	3	revealed	reveal	VERB
fnp-8974	417	4	features	feature	NOUN
fnp-8974	417	5	reminiscent	reminiscent	ADJ
fnp-8974	417	6	of	of	ADP
fnp-8974	417	7	other	other	ADJ
fnp-8974	417	8	pineal	pineal	ADJ
fnp-8974	417	9	tumors	tumor	NOUN
fnp-8974	417	10	,	,	PUNCT
fnp-8974	417	11	including	include	VERB
fnp-8974	417	12	papillary	papillary	ADJ
fnp-8974	417	13	architecture	architecture	NOUN
fnp-8974	417	14	and	and	CCONJ
fnp-8974	417	15	expression	expression	NOUN
fnp-8974	417	16	of	of	ADP
fnp-8974	417	17	cytokeratin	cytokeratin	NOUN
fnp-8974	417	18	,	,	PUNCT
fnp-8974	417	19	synaptophysin	synaptophysin	NOUN
fnp-8974	417	20	,	,	PUNCT
fnp-8974	417	21	and	and	CCONJ
fnp-8974	417	22	otx2	otx2	PROPN
fnp-8974	417	23	.	.	PUNCT
fnp-8974	418	1	a	a	DET
fnp-8974	418	2	subset	subset	NOUN
fnp-8974	418	3	of	of	ADP
fnp-8974	418	4	our	our	PRON
fnp-8974	418	5	tumors	tumor	NOUN
fnp-8974	418	6	also	also	ADV
fnp-8974	418	7	focally	focally	ADV
fnp-8974	418	8	expressed	express	VERB
fnp-8974	418	9	desmin	desmin	NOUN
fnp-8974	418	10	,	,	PUNCT
fnp-8974	418	11	whereas	whereas	SCONJ
fnp-8974	418	12	all	all	DET
fnp-8974	418	13	tumors	tumor	NOUN
fnp-8974	418	14	lacked	lack	VERB
fnp-8974	418	15	crx	crx	PROPN
fnp-8974	418	16	expression	expression	NOUN
fnp-8974	418	17	.	.	PUNCT
fnp-8974	419	1	notably	notably	ADV
fnp-8974	419	2	,	,	PUNCT
fnp-8974	419	3	10	10	NUM
fnp-8974	419	4	of	of	ADP
fnp-8974	419	5	the	the	DET
fnp-8974	419	6	13	13	NUM
fnp-8974	419	7	tumors	tumor	NOUN
fnp-8974	419	8	analyzed	analyze	VERB
fnp-8974	419	9	harbored	harbor	VERB
fnp-8974	419	10	a	a	DET
fnp-8974	419	11	novel	novel	ADJ
fnp-8974	419	12	rp11	rp11	PROPN
fnp-8974	419	13	-	-	PUNCT
fnp-8974	419	14	331k21.1	331k21.1	NUM
fnp-8974	419	15	:	:	PUNCT
fnp-8974	419	16	sh3tc2	sh3tc2	NOUN
fnp-8974	419	17	gene	gene	NOUN
fnp-8974	419	18	fusion	fusion	NOUN
fnp-8974	419	19	,	,	PUNCT
fnp-8974	419	20	which	which	PRON
fnp-8974	419	21	has	have	AUX
fnp-8974	419	22	not	not	PART
fnp-8974	419	23	previously	previously	ADV
fnp-8974	419	24	been	be	AUX
fnp-8974	419	25	reported	report	VERB
fnp-8974	419	26	in	in	ADP
fnp-8974	419	27	any	any	DET
fnp-8974	419	28	cns	cns	NOUN
fnp-8974	419	29	tumor	tumor	NOUN
fnp-8974	419	30	entity	entity	NOUN
fnp-8974	419	31	.	.	PUNCT
fnp-8974	420	1	taken	take	VERB
fnp-8974	420	2	together	together	ADV
fnp-8974	420	3	,	,	PUNCT
fnp-8974	420	4	our	our	PRON
fnp-8974	420	5	findings	finding	NOUN
fnp-8974	420	6	define	define	VERB
fnp-8974	420	7	a	a	DET
fnp-8974	420	8	novel	novel	ADJ
fnp-8974	420	9	molecular	molecular	ADJ
fnp-8974	420	10	subgroup	subgroup	NOUN
fnp-8974	420	11	of	of	ADP
fnp-8974	420	12	pineal	pineal	ADJ
fnp-8974	420	13	region	region	NOUN
fnp-8974	420	14	tumors	tumor	NOUN
fnp-8974	420	15	characterized	characterize	VERB
fnp-8974	420	16	by	by	ADP
fnp-8974	420	17	sh3tc2	sh3tc2	NOUN
fnp-8974	420	18	fusions	fusion	NOUN
fnp-8974	420	19	and	and	CCONJ
fnp-8974	420	20	a	a	DET
fnp-8974	420	21	unique	unique	ADJ
fnp-8974	420	22	dna	dna	NOUN
fnp-8974	420	23	methylation	methylation	NOUN
fnp-8974	420	24	signature	signature	NOUN
fnp-8974	420	25	.	.	PUNCT
fnp-8974	421	1	recognition	recognition	NOUN
fnp-8974	421	2	of	of	ADP
fnp-8974	421	3	this	this	DET
fnp-8974	421	4	group	group	NOUN
fnp-8974	421	5	is	be	AUX
fnp-8974	421	6	important	important	ADJ
fnp-8974	421	7	for	for	ADP
fnp-8974	421	8	accurate	accurate	ADJ
fnp-8974	421	9	diagnosis	diagnosis	NOUN
fnp-8974	421	10	and	and	CCONJ
fnp-8974	421	11	may	may	AUX
fnp-8974	421	12	have	have	VERB
fnp-8974	421	13	implications	implication	NOUN
fnp-8974	421	14	for	for	ADP
fnp-8974	421	15	future	future	ADJ
fnp-8974	421	16	tumor	tumor	NOUN
fnp-8974	421	17	classification	classification	NOUN
fnp-8974	421	18	and	and	CCONJ
fnp-8974	421	19	treatment	treatment	NOUN
fnp-8974	421	20	strategies	strategy	NOUN
fnp-8974	421	21	.	.	PUNCT
fnp-8974	422	1	p33	p33	NOUN
fnp-8974	422	2	free	free	ADJ
fnp-8974	422	3	neuropathol	neuropathol	NOUN
fnp-8974	422	4	6:17:51	6:17:51	NUM
fnp-8974	422	5	ttf-1	ttf-1	NOUN
fnp-8974	422	6	expression	expression	NOUN
fnp-8974	422	7	is	be	AUX
fnp-8974	422	8	associated	associate	VERB
fnp-8974	422	9	with	with	ADP
fnp-8974	422	10	a	a	DET
fnp-8974	422	11	hypomethylation	hypomethylation	NOUN
fnp-8974	422	12	signature	signature	NOUN
fnp-8974	422	13	in	in	ADP
fnp-8974	422	14	schwannomas	schwannomas	PROPN
fnp-8974	422	15	max	max	PROPN
fnp-8974	422	16	braune1	braune1	PROPN
fnp-8974	422	17	,	,	PUNCT
fnp-8974	422	18	alim	alim	PROPN
fnp-8974	422	19	e.	e.	PROPN
fnp-8974	422	20	basaran2	basaran2	PROPN
fnp-8974	422	21	,	,	PUNCT
fnp-8974	422	22	peter	peter	PROPN
fnp-8974	422	23	kuzman1	kuzman1	PROPN
fnp-8974	422	24	,	,	PUNCT
fnp-8974	422	25	johannes	johannes	PROPN
fnp-8974	422	26	wach2	wach2	PROPN
fnp-8974	422	27	,	,	PUNCT
fnp-8974	422	28	erdem	erdem	PROPN
fnp-8974	422	29	güresir2	güresir2	PROPN
fnp-8974	422	30	,	,	PUNCT
fnp-8974	422	31	ruth	ruth	PROPN
fnp-8974	422	32	m.	m.	NOUN
fnp-8974	422	33	stassart1	stassart1	NOUN
fnp-8974	422	34	,	,	PUNCT
fnp-8974	422	35	wolf	wolf	PROPN
fnp-8974	422	36	müller1	müller1	PROPN
fnp-8974	422	37	,	,	PUNCT
fnp-8974	422	38	alonso	alonso	PROPN
fnp-8974	422	39	barrantes	barrantes	PROPN
fnp-8974	422	40	-	-	PUNCT
fnp-8974	422	41	freer1	freer1	NOUN
fnp-8974	422	42	1	1	NUM
fnp-8974	422	43	paul	paul	PROPN
fnp-8974	422	44	-	-	PUNCT
fnp-8974	422	45	flechsig	flechsig	NOUN
fnp-8974	422	46	-	-	PUNCT
fnp-8974	422	47	institute	institute	NOUN
fnp-8974	422	48	of	of	ADP
fnp-8974	422	49	neuropathology	neuropathology	NOUN
fnp-8974	422	50	,	,	PUNCT
fnp-8974	422	51	university	university	NOUN
fnp-8974	422	52	hospital	hospital	NOUN
fnp-8974	422	53	leipzig	leipzig	PROPN
fnp-8974	422	54	,	,	PUNCT
fnp-8974	422	55	leipzig	leipzig	PROPN
fnp-8974	422	56	,	,	PUNCT
fnp-8974	422	57	germany	germany	PROPN
fnp-8974	422	58	2	2	NUM
fnp-8974	422	59	department	department	NOUN
fnp-8974	422	60	of	of	ADP
fnp-8974	422	61	neurosurgery	neurosurgery	NOUN
fnp-8974	422	62	,	,	PUNCT
fnp-8974	422	63	university	university	NOUN
fnp-8974	422	64	hospital	hospital	NOUN
fnp-8974	422	65	leipzig	leipzig	PROPN
fnp-8974	422	66	,	,	PUNCT
fnp-8974	422	67	leipzig	leipzig	PROPN
fnp-8974	422	68	,	,	PUNCT
fnp-8974	422	69	germany	germany	PROPN
fnp-8974	422	70	background	background	NOUN
fnp-8974	422	71	:	:	PUNCT
fnp-8974	422	72	thyroid	thyroid	NOUN
fnp-8974	422	73	transcription	transcription	NOUN
fnp-8974	422	74	factor-1	factor-1	PROPN
fnp-8974	422	75	(	(	PUNCT
fnp-8974	422	76	ttf-1/	ttf-1/	PROPN
fnp-8974	422	77	nkx2.1	nkx2.1	NOUN
fnp-8974	422	78	)	)	PUNCT
fnp-8974	422	79	is	be	AUX
fnp-8974	422	80	a	a	DET
fnp-8974	422	81	well	well	ADV
fnp-8974	422	82	-	-	PUNCT
fnp-8974	422	83	known	know	VERB
fnp-8974	422	84	transcription	transcription	NOUN
fnp-8974	422	85	factor	factor	NOUN
fnp-8974	422	86	,	,	PUNCT
fnp-8974	422	87	most	most	ADV
fnp-8974	422	88	notably	notably	ADV
fnp-8974	422	89	associated	associate	VERB
fnp-8974	422	90	with	with	ADP
fnp-8974	422	91	adenocarcinoma	adenocarcinoma	NOUN
fnp-8974	422	92	of	of	ADP
fnp-8974	422	93	the	the	DET
fnp-8974	422	94	lung	lung	NOUN
fnp-8974	422	95	.	.	PUNCT
fnp-8974	423	1	recently	recently	ADV
fnp-8974	423	2	,	,	PUNCT
fnp-8974	423	3	ttf-1	ttf-1	NOUN
fnp-8974	423	4	expression	expression	NOUN
fnp-8974	423	5	has	have	AUX
fnp-8974	423	6	been	be	AUX
fnp-8974	423	7	reported	report	VERB
fnp-8974	423	8	in	in	ADP
fnp-8974	423	9	a	a	DET
fnp-8974	423	10	subgroup	subgroup	NOUN
fnp-8974	423	11	of	of	ADP
fnp-8974	423	12	schwannomas	schwannoma	NOUN
fnp-8974	423	13	,	,	PUNCT
fnp-8974	423	14	though	though	SCONJ
fnp-8974	423	15	its	its	PRON
fnp-8974	423	16	biological	biological	ADJ
fnp-8974	423	17	and	and	CCONJ
fnp-8974	423	18	clinical	clinical	ADJ
fnp-8974	423	19	significance	significance	NOUN
fnp-8974	423	20	remains	remain	VERB
fnp-8974	423	21	unclear	unclear	ADJ
fnp-8974	423	22	.	.	PUNCT
fnp-8974	424	1	objectives	objective	NOUN
fnp-8974	424	2	:	:	PUNCT
fnp-8974	424	3	this	this	DET
fnp-8974	424	4	study	study	NOUN
fnp-8974	424	5	aims	aim	VERB
fnp-8974	424	6	to	to	PART
fnp-8974	424	7	characterize	characterize	VERB
fnp-8974	424	8	the	the	DET
fnp-8974	424	9	epigenetic	epigenetic	ADJ
fnp-8974	424	10	and	and	CCONJ
fnp-8974	424	11	clinical	clinical	ADJ
fnp-8974	424	12	features	feature	NOUN
fnp-8974	424	13	of	of	ADP
fnp-8974	424	14	ttf-1	ttf-1	ADV
fnp-8974	424	15	-	-	PUNCT
fnp-8974	424	16	positive	positive	ADJ
fnp-8974	424	17	schwannomas	schwannoma	NOUN
fnp-8974	424	18	.	.	PUNCT
fnp-8974	425	1	questions	question	NOUN
fnp-8974	425	2	:	:	PUNCT
fnp-8974	425	3	do	do	AUX
fnp-8974	425	4	ttf-1	ttf-1	ADV
fnp-8974	425	5	-	-	PUNCT
fnp-8974	425	6	positive	positive	ADJ
fnp-8974	425	7	schwannomas	schwannoma	NOUN
fnp-8974	425	8	exhibit	exhibit	VERB
fnp-8974	425	9	a	a	DET
fnp-8974	425	10	distinct	distinct	ADJ
fnp-8974	425	11	epigenetic	epigenetic	ADJ
fnp-8974	425	12	signature	signature	NOUN
fnp-8974	425	13	?	?	PUNCT
fnp-8974	426	1	how	how	SCONJ
fnp-8974	426	2	is	be	AUX
fnp-8974	426	3	this	this	DET
fnp-8974	426	4	signature	signature	NOUN
fnp-8974	426	5	characterized	characterize	VERB
fnp-8974	426	6	?	?	PUNCT
fnp-8974	427	1	could	could	AUX
fnp-8974	427	2	ttf-1	ttf-1	PRON
fnp-8974	427	3	expression	expression	NOUN
fnp-8974	427	4	define	define	VERB
fnp-8974	427	5	a	a	DET
fnp-8974	427	6	biologically	biologically	ADV
fnp-8974	427	7	distinct	distinct	ADJ
fnp-8974	427	8	schwannoma	schwannoma	PROPN
fnp-8974	427	9	subgroup	subgroup	PROPN
fnp-8974	427	10	?	?	PUNCT
fnp-8974	428	1	is	be	AUX
fnp-8974	428	2	ttf-1	ttf-1	NUM
fnp-8974	428	3	expression	expression	NOUN
fnp-8974	428	4	associated	associate	VERB
fnp-8974	428	5	with	with	ADP
fnp-8974	428	6	clinical	clinical	ADJ
fnp-8974	428	7	features	feature	NOUN
fnp-8974	428	8	such	such	ADJ
fnp-8974	428	9	as	as	ADP
fnp-8974	428	10	localization	localization	NOUN
fnp-8974	428	11	or	or	CCONJ
fnp-8974	428	12	growth	growth	NOUN
fnp-8974	428	13	behavior	behavior	NOUN
fnp-8974	428	14	?	?	PUNCT
fnp-8974	429	1	methods	method	NOUN
fnp-8974	429	2	:	:	PUNCT
fnp-8974	429	3	we	we	PRON
fnp-8974	429	4	performed	perform	VERB
fnp-8974	429	5	immunohistochemical	immunohistochemical	ADJ
fnp-8974	429	6	,	,	PUNCT
fnp-8974	429	7	and	and	CCONJ
fnp-8974	429	8	clinical	clinical	ADJ
fnp-8974	429	9	analyses	analysis	NOUN
fnp-8974	429	10	on	on	ADP
fnp-8974	429	11	67	67	NUM
fnp-8974	429	12	schwannomas	schwannoma	NOUN
fnp-8974	429	13	,	,	PUNCT
fnp-8974	429	14	including	include	VERB
fnp-8974	429	15	vestibular	vestibular	ADJ
fnp-8974	429	16	,	,	PUNCT
fnp-8974	429	17	spinal	spinal	NOUN
fnp-8974	429	18	,	,	PUNCT
fnp-8974	429	19	and	and	CCONJ
fnp-8974	429	20	peripheral	peripheral	ADJ
fnp-8974	429	21	schwannomas	schwannoma	NOUN
fnp-8974	429	22	.	.	PUNCT
fnp-8974	430	1	ttf-1	ttf-1	NUM
fnp-8974	430	2	expression	expression	NOUN
fnp-8974	430	3	was	be	AUX
fnp-8974	430	4	assessed	assess	VERB
fnp-8974	430	5	by	by	ADP
fnp-8974	430	6	immunohistochemistry	immunohistochemistry	NOUN
fnp-8974	430	7	.	.	PUNCT
fnp-8974	431	1	epigenetic	epigenetic	ADJ
fnp-8974	431	2	profiling	profiling	NOUN
fnp-8974	431	3	of	of	ADP
fnp-8974	431	4	24	24	NUM
fnp-8974	431	5	schwannomas	schwannoma	NOUN
fnp-8974	431	6	was	be	AUX
fnp-8974	431	7	conducted	conduct	VERB
fnp-8974	431	8	using	use	VERB
fnp-8974	431	9	the	the	DET
fnp-8974	431	10	illumina	illumina	PROPN
fnp-8974	431	11	epic	epic	PROPN
fnp-8974	431	12	850k	850k	PROPN
fnp-8974	431	13	array	array	VERB
fnp-8974	431	14	.	.	PUNCT
fnp-8974	432	1	bioinformatic	bioinformatic	ADJ
fnp-8974	432	2	analysis	analysis	NOUN
fnp-8974	432	3	was	be	AUX
fnp-8974	432	4	performed	perform	VERB
fnp-8974	432	5	using	use	VERB
fnp-8974	432	6	established	establish	VERB
fnp-8974	432	7	r	r	NOUN
fnp-8974	432	8	packages	package	NOUN
fnp-8974	432	9	(	(	PUNCT
fnp-8974	432	10	champ	champ	NOUN
fnp-8974	432	11	,	,	PUNCT
fnp-8974	432	12	limma	limma	PROPN
fnp-8974	432	13	)	)	PUNCT
fnp-8974	432	14	.	.	PUNCT
fnp-8974	433	1	results	result	NOUN
fnp-8974	433	2	:	:	PUNCT
fnp-8974	434	1	unsupervised	unsupervised	ADJ
fnp-8974	434	2	dimensionality	dimensionality	NOUN
fnp-8974	434	3	reduction	reduction	NOUN
fnp-8974	434	4	using	use	VERB
fnp-8974	434	5	t	t	PROPN
fnp-8974	434	6	-	-	PUNCT
fnp-8974	434	7	sne	sne	PROPN
fnp-8974	434	8	and	and	CCONJ
fnp-8974	434	9	umap	umap	ADJ
fnp-8974	434	10	revealed	reveal	VERB
fnp-8974	434	11	distinct	distinct	ADJ
fnp-8974	434	12	clustering	clustering	NOUN
fnp-8974	434	13	of	of	ADP
fnp-8974	434	14	ttf-1	ttf-1	ADV
fnp-8974	434	15	-	-	PUNCT
fnp-8974	434	16	positive	positive	ADJ
fnp-8974	434	17	schwannomas	schwannoma	NOUN
fnp-8974	434	18	,	,	PUNCT
fnp-8974	434	19	based	base	VERB
fnp-8974	434	20	on	on	ADP
fnp-8974	434	21	the	the	DET
fnp-8974	434	22	1,000	1,000	NUM
fnp-8974	434	23	most	most	ADV
fnp-8974	434	24	variable	variable	ADJ
fnp-8974	434	25	cpg	cpg	NOUN
fnp-8974	434	26	sites	site	NOUN
fnp-8974	434	27	.	.	PUNCT
fnp-8974	435	1	differential	differential	ADJ
fnp-8974	435	2	methylation	methylation	NOUN
fnp-8974	435	3	analysis	analysis	NOUN
fnp-8974	435	4	revealed	reveal	VERB
fnp-8974	435	5	2,234	2,234	NUM
fnp-8974	435	6	cpg	cpg	NOUN
fnp-8974	435	7	sites	site	NOUN
fnp-8974	435	8	,	,	PUNCT
fnp-8974	435	9	predominantly	predominantly	ADV
fnp-8974	435	10	hypomethylated	hypomethylate	VERB
fnp-8974	435	11	(	(	PUNCT
fnp-8974	435	12	n	n	CCONJ
fnp-8974	435	13	 	 	SPACE
fnp-8974	435	14	=	=	NOUN
fnp-8974	435	15	 	 	SPACE
fnp-8974	435	16	1,924	1,924	NUM
fnp-8974	435	17	)	)	PUNCT
fnp-8974	435	18	.	.	PUNCT
fnp-8974	436	1	enrichment	enrichment	NOUN
fnp-8974	436	2	analysis	analysis	NOUN
fnp-8974	436	3	(	(	PUNCT
fnp-8974	436	4	kegg	kegg	NOUN
fnp-8974	436	5	,	,	PUNCT
fnp-8974	436	6	go	go	VERB
fnp-8974	436	7	)	)	PUNCT
fnp-8974	436	8	indicated	indicate	VERB
fnp-8974	436	9	enrichment	enrichment	NOUN
fnp-8974	436	10	of	of	ADP
fnp-8974	436	11	cancer	cancer	NOUN
fnp-8974	436	12	-	-	PUNCT
fnp-8974	436	13	related	relate	VERB
fnp-8974	436	14	pathways	pathway	NOUN
fnp-8974	436	15	(	(	PUNCT
fnp-8974	436	16	pi3k	pi3k	NOUN
fnp-8974	436	17	/	/	SYM
fnp-8974	436	18	akt	akt	PROPN
fnp-8974	436	19	/	/	SYM
fnp-8974	436	20	mtor	mtor	PROPN
fnp-8974	436	21	,	,	PUNCT
fnp-8974	436	22	mapk	mapk	PROPN
fnp-8974	436	23	,	,	PUNCT
fnp-8974	436	24	hippo	hippo	NOUN
fnp-8974	436	25	)	)	PUNCT
fnp-8974	436	26	in	in	ADP
fnp-8974	436	27	differentially	differentially	ADV
fnp-8974	436	28	methylated	methylate	VERB
fnp-8974	436	29	cpg	cpg	NOUN
fnp-8974	436	30	sites	site	NOUN
fnp-8974	436	31	of	of	ADP
fnp-8974	436	32	ttf-1	ttf-1	ADV
fnp-8974	436	33	-	-	PUNCT
fnp-8974	436	34	positive	positive	ADJ
fnp-8974	436	35	schwannomas	schwannoma	NOUN
fnp-8974	436	36	.	.	PUNCT
fnp-8974	437	1	the	the	DET
fnp-8974	437	2	ttf-1	ttf-1	ADV
fnp-8974	437	3	/	/	SYM
fnp-8974	437	4	nkx2.1	nkx2.1	NOUN
fnp-8974	437	5	locus	locus	NOUN
fnp-8974	437	6	itself	itself	PRON
fnp-8974	437	7	showed	show	VERB
fnp-8974	437	8	no	no	DET
fnp-8974	437	9	differential	differential	ADJ
fnp-8974	437	10	methylation	methylation	NOUN
fnp-8974	437	11	but	but	CCONJ
fnp-8974	437	12	exhibited	exhibit	VERB
fnp-8974	437	13	increased	increase	VERB
fnp-8974	437	14	copy	copy	NOUN
fnp-8974	437	15	number	number	NOUN
fnp-8974	437	16	variation	variation	NOUN
fnp-8974	437	17	,	,	PUNCT
fnp-8974	437	18	particularly	particularly	ADV
fnp-8974	437	19	in	in	ADP
fnp-8974	437	20	spinal	spinal	ADJ
fnp-8974	437	21	schwannomas	schwannoma	NOUN
fnp-8974	437	22	.	.	PUNCT
fnp-8974	438	1	mib1	mib1	NOUN
fnp-8974	438	2	staining	stain	VERB
fnp-8974	438	3	suggested	suggest	VERB
fnp-8974	438	4	higher	high	ADJ
fnp-8974	438	5	proliferative	proliferative	ADJ
fnp-8974	438	6	activity	activity	NOUN
fnp-8974	438	7	in	in	ADP
fnp-8974	438	8	ttf-1	ttf-1	ADV
fnp-8974	438	9	-	-	PUNCT
fnp-8974	438	10	positive	positive	ADJ
fnp-8974	438	11	spinal	spinal	ADJ
fnp-8974	438	12	schwannomas	schwannoma	NOUN
fnp-8974	438	13	.	.	PUNCT
fnp-8974	439	1	limited	limited	ADJ
fnp-8974	439	2	follow	follow	NOUN
fnp-8974	439	3	-	-	PUNCT
fnp-8974	439	4	up	up	ADP
fnp-8974	439	5	data	datum	NOUN
fnp-8974	439	6	indicated	indicate	VERB
fnp-8974	439	7	a	a	DET
fnp-8974	439	8	tendency	tendency	NOUN
fnp-8974	439	9	toward	toward	ADP
fnp-8974	439	10	increased	increase	VERB
fnp-8974	439	11	facial	facial	ADJ
fnp-8974	439	12	nerve	nerve	NOUN
fnp-8974	439	13	involvement	involvement	NOUN
fnp-8974	439	14	and	and	CCONJ
fnp-8974	439	15	proximity	proximity	NOUN
fnp-8974	439	16	to	to	ADP
fnp-8974	439	17	the	the	DET
fnp-8974	439	18	brainstem	brainstem	NOUN
fnp-8974	439	19	.	.	PUNCT
fnp-8974	440	1	conclusions	conclusion	NOUN
fnp-8974	440	2	:	:	PUNCT
fnp-8974	440	3	ttf-1	ttf-1	X
fnp-8974	440	4	expression	expression	NOUN
fnp-8974	440	5	defines	define	VERB
fnp-8974	440	6	a	a	DET
fnp-8974	440	7	schwannoma	schwannoma	ADJ
fnp-8974	440	8	subgroup	subgroup	NOUN
fnp-8974	440	9	with	with	ADP
fnp-8974	440	10	distinct	distinct	ADJ
fnp-8974	440	11	epigenetic	epigenetic	ADJ
fnp-8974	440	12	alterations	alteration	NOUN
fnp-8974	440	13	.	.	PUNCT
fnp-8974	441	1	further	further	ADJ
fnp-8974	441	2	studies	study	NOUN
fnp-8974	441	3	are	be	AUX
fnp-8974	441	4	needed	need	VERB
fnp-8974	441	5	to	to	PART
fnp-8974	441	6	clarify	clarify	VERB
fnp-8974	441	7	its	its	PRON
fnp-8974	441	8	clinical	clinical	ADJ
fnp-8974	441	9	implications	implication	NOUN
fnp-8974	441	10	.	.	PUNCT
fnp-8974	442	1	p34	p34	VERB
fnp-8974	442	2	free	free	ADJ
fnp-8974	442	3	neuropathol	neuropathol	NOUN
fnp-8974	442	4	6:17:52	6:17:52	NUM
fnp-8974	442	5	expansion	expansion	NOUN
fnp-8974	442	6	of	of	ADP
fnp-8974	442	7	the	the	DET
fnp-8974	442	8	spectrum	spectrum	NOUN
fnp-8974	442	9	of	of	ADP
fnp-8974	442	10	tumors	tumor	NOUN
fnp-8974	442	11	diagnosed	diagnose	VERB
fnp-8974	442	12	as	as	ADP
fnp-8974	442	13	myxopapillary	myxopapillary	PROPN
fnp-8974	442	14	ependymomas	ependymomas	PROPN
fnp-8974	442	15	fuat	fuat	PROPN
fnp-8974	442	16	aras1	aras1	PROPN
fnp-8974	442	17	,	,	PUNCT
fnp-8974	442	18	dennis	dennis	PROPN
fnp-8974	442	19	friedel1	friedel1	PROPN
fnp-8974	442	20	,	,	PUNCT
fnp-8974	442	21	david	david	PROPN
fnp-8974	442	22	reuss1	reuss1	PROPN
fnp-8974	442	23	,	,	PUNCT
fnp-8974	442	24	gianluca	gianluca	PROPN
fnp-8974	442	25	sigismondo1	sigismondo1	PROPN
fnp-8974	442	26	,	,	PUNCT
fnp-8974	442	27	andreas	andreas	PROPN
fnp-8974	442	28	von	von	PROPN
fnp-8974	442	29	deimling1	deimling1	PROPN
fnp-8974	442	30	1	1	NUM
fnp-8974	442	31	universitätsklinikum	universitätsklinikum	NOUN
fnp-8974	442	32	heidelberg	heidelberg	NOUN
fnp-8974	442	33	,	,	PUNCT
fnp-8974	442	34	neuropathologie	neuropathologie	NOUN
fnp-8974	442	35	,	,	PUNCT
fnp-8974	442	36	heidelberg	heidelberg	PROPN
fnp-8974	442	37	,	,	PUNCT
fnp-8974	442	38	germany	germany	PROPN
fnp-8974	442	39	background	background	NOUN
fnp-8974	442	40	:	:	PUNCT
fnp-8974	442	41	for	for	ADP
fnp-8974	442	42	a	a	DET
fnp-8974	442	43	significant	significant	ADJ
fnp-8974	442	44	portion	portion	NOUN
fnp-8974	442	45	of	of	ADP
fnp-8974	442	46	spinal	spinal	ADJ
fnp-8974	442	47	ependymomas	ependymomas	PROPN
fnp-8974	442	48	(	(	PUNCT
fnp-8974	442	49	spe	spe	PROPN
fnp-8974	442	50	)	)	PUNCT
fnp-8974	442	51	,	,	PUNCT
fnp-8974	442	52	pathologists	pathologist	NOUN
fnp-8974	442	53	reported	report	VERB
fnp-8974	442	54	conflicting	conflicting	ADJ
fnp-8974	442	55	results	result	NOUN
fnp-8974	442	56	between	between	ADP
fnp-8974	442	57	morphologic	morphologic	ADJ
fnp-8974	442	58	diagnosis	diagnosis	NOUN
fnp-8974	442	59	and	and	CCONJ
fnp-8974	442	60	the	the	DET
fnp-8974	442	61	dna	dna	PROPN
fnp-8974	442	62	methylation	methylation	NOUN
fnp-8974	442	63	-	-	PUNCT
fnp-8974	442	64	based	base	VERB
fnp-8974	442	65	classification	classification	NOUN
fnp-8974	442	66	.	.	PUNCT
fnp-8974	443	1	a	a	DET
fnp-8974	443	2	study	study	NOUN
fnp-8974	443	3	by	by	ADP
fnp-8974	443	4	the	the	DET
fnp-8974	443	5	german	german	ADJ
fnp-8974	443	6	glioma	glioma	NOUN
fnp-8974	443	7	network	network	NOUN
fnp-8974	443	8	reported	report	VERB
fnp-8974	443	9	that	that	SCONJ
fnp-8974	443	10	nearly	nearly	ADV
fnp-8974	443	11	one	one	NUM
fnp-8974	443	12	third	third	NOUN
fnp-8974	443	13	of	of	ADP
fnp-8974	443	14	the	the	DET
fnp-8974	443	15	histologically	histologically	ADV
fnp-8974	443	16	diagnosed	diagnose	VERB
fnp-8974	443	17	spinal	spinal	NOUN
fnp-8974	443	18	ependymomas	ependymoma	NOUN
fnp-8974	443	19	were	be	AUX
fnp-8974	443	20	assigned	assign	VERB
fnp-8974	443	21	by	by	ADP
fnp-8974	443	22	methylation	methylation	NOUN
fnp-8974	443	23	to	to	ADP
fnp-8974	443	24	the	the	DET
fnp-8974	443	25	myxopapillary	myxopapillary	ADJ
fnp-8974	443	26	ependymoma	ependymoma	NOUN
fnp-8974	443	27	(	(	PUNCT
fnp-8974	443	28	mpe	mpe	ADJ
fnp-8974	443	29	)	)	PUNCT
fnp-8974	443	30	class	class	NOUN
fnp-8974	443	31	.	.	PUNCT
fnp-8974	444	1	objective(s	objective(s	NOUN
fnp-8974	444	2	):	):	PUNCT
fnp-8974	444	3	we	we	PRON
fnp-8974	444	4	address	address	VERB
fnp-8974	444	5	this	this	DET
fnp-8974	444	6	topic	topic	NOUN
fnp-8974	444	7	and	and	CCONJ
fnp-8974	444	8	focus	focus	VERB
fnp-8974	444	9	on	on	ADP
fnp-8974	444	10	spe	spe	ADJ
fnp-8974	444	11	cases	case	NOUN
fnp-8974	444	12	exhibiting	exhibit	VERB
fnp-8974	444	13	a	a	DET
fnp-8974	444	14	methylation	methylation	NOUN
fnp-8974	444	15	profile	profile	NOUN
fnp-8974	444	16	of	of	ADP
fnp-8974	444	17	mpe	mpe	PROPN
fnp-8974	444	18	.	.	PUNCT
fnp-8974	445	1	method(s	method(s	PROPN
fnp-8974	445	2	):	):	PUNCT
fnp-8974	445	3	we	we	PRON
fnp-8974	445	4	performed	perform	VERB
fnp-8974	445	5	immunohistochemical	immunohistochemical	ADJ
fnp-8974	445	6	,	,	PUNCT
fnp-8974	445	7	ai	ai	AUX
fnp-8974	445	8	-	-	PUNCT
fnp-8974	445	9	assisted	assist	VERB
fnp-8974	445	10	morphological	morphological	ADJ
fnp-8974	445	11	and	and	CCONJ
fnp-8974	445	12	methylation	methylation	NOUN
fnp-8974	445	13	analyses	analysis	NOUN
fnp-8974	445	14	on	on	ADP
fnp-8974	445	15	100	100	NUM
fnp-8974	445	16	mpes	mpe	NOUN
fnp-8974	445	17	and	and	CCONJ
fnp-8974	445	18	spes	spe	NOUN
fnp-8974	445	19	.	.	PUNCT
fnp-8974	446	1	mass	mass	PROPN
fnp-8974	446	2	spectrometry	spectrometry	NOUN
fnp-8974	446	3	-	-	PUNCT
fnp-8974	446	4	based	base	VERB
fnp-8974	446	5	proteomic	proteomic	ADJ
fnp-8974	446	6	analysis	analysis	NOUN
fnp-8974	446	7	was	be	AUX
fnp-8974	446	8	conducted	conduct	VERB
fnp-8974	446	9	on	on	ADP
fnp-8974	446	10	54	54	NUM
fnp-8974	446	11	of	of	ADP
fnp-8974	446	12	these	these	DET
fnp-8974	446	13	tumors	tumor	NOUN
fnp-8974	446	14	.	.	PUNCT
fnp-8974	447	1	result(s	result(s	PROPN
fnp-8974	447	2	):	):	PUNCT
fnp-8974	447	3	pearson	pearson	NOUN
fnp-8974	447	4	correlation	correlation	NOUN
fnp-8974	447	5	matrix	matrix	NOUN
fnp-8974	447	6	showed	show	VERB
fnp-8974	447	7	higher	high	ADJ
fnp-8974	447	8	similarity	similarity	NOUN
fnp-8974	447	9	between	between	ADP
fnp-8974	447	10	discrepant	discrepant	ADJ
fnp-8974	447	11	cases	case	NOUN
fnp-8974	447	12	and	and	CCONJ
fnp-8974	447	13	mpes	mpe	NOUN
fnp-8974	447	14	.	.	PUNCT
fnp-8974	448	1	principal	principal	ADJ
fnp-8974	448	2	component	component	NOUN
fnp-8974	448	3	analysis	analysis	NOUN
fnp-8974	448	4	revealed	reveal	VERB
fnp-8974	448	5	predominant	predominant	ADJ
fnp-8974	448	6	clustering	clustering	NOUN
fnp-8974	448	7	of	of	ADP
fnp-8974	448	8	the	the	DET
fnp-8974	448	9	discrepant	discrepant	ADJ
fnp-8974	448	10	cases	case	NOUN
fnp-8974	448	11	with	with	ADP
fnp-8974	448	12	mpes	mpe	NOUN
fnp-8974	448	13	.	.	PUNCT
fnp-8974	449	1	proteomic	proteomic	ADJ
fnp-8974	449	2	analysis	analysis	NOUN
fnp-8974	449	3	identified	identify	VERB
fnp-8974	449	4	hoxb13	hoxb13	NOUN
fnp-8974	449	5	as	as	ADP
fnp-8974	449	6	the	the	DET
fnp-8974	449	7	most	most	ADV
fnp-8974	449	8	differentially	differentially	ADV
fnp-8974	449	9	expressed	express	VERB
fnp-8974	449	10	protein	protein	NOUN
fnp-8974	449	11	between	between	ADP
fnp-8974	449	12	mpe	mpe	PROPN
fnp-8974	449	13	and	and	CCONJ
fnp-8974	449	14	spe	spe	NOUN
fnp-8974	449	15	.	.	PUNCT
fnp-8974	450	1	immunohistochemical	immunohistochemical	ADJ
fnp-8974	450	2	staining	staining	NOUN
fnp-8974	450	3	of	of	ADP
fnp-8974	450	4	100	100	NUM
fnp-8974	450	5	tumor	tumor	NOUN
fnp-8974	450	6	samples	sample	NOUN
fnp-8974	450	7	demonstrated	demonstrate	VERB
fnp-8974	450	8	100	100	NUM
fnp-8974	450	9	 	 	SPACE
fnp-8974	450	10	%	%	NOUN
fnp-8974	450	11	sensitivity	sensitivity	NOUN
fnp-8974	450	12	and	and	CCONJ
fnp-8974	450	13	100	100	NUM
fnp-8974	450	14	 	 	SPACE
fnp-8974	450	15	%	%	NOUN
fnp-8974	450	16	specificity	specificity	NOUN
fnp-8974	450	17	.	.	PUNCT
fnp-8974	451	1	hoxb13	hoxb13	PROPN
fnp-8974	451	2	showed	show	VERB
fnp-8974	451	3	positive	positive	ADJ
fnp-8974	451	4	staining	staining	NOUN
fnp-8974	451	5	in	in	ADP
fnp-8974	451	6	all	all	DET
fnp-8974	451	7	discrepant	discrepant	ADJ
fnp-8974	451	8	cases	case	NOUN
fnp-8974	451	9	.	.	PUNCT
fnp-8974	452	1	the	the	DET
fnp-8974	452	2	extracellular	extracellular	ADJ
fnp-8974	452	3	proteoglycan	proteoglycan	ADJ
fnp-8974	452	4	versican	versican	NOUN
fnp-8974	452	5	was	be	AUX
fnp-8974	452	6	overrepresented	overrepresente	VERB
fnp-8974	452	7	in	in	ADP
fnp-8974	452	8	the	the	DET
fnp-8974	452	9	myxoid	myxoid	ADJ
fnp-8974	452	10	matrix	matrix	NOUN
fnp-8974	452	11	of	of	ADP
fnp-8974	452	12	mpe	mpe	PROPN
fnp-8974	452	13	.	.	PUNCT
fnp-8974	453	1	employing	employ	VERB
fnp-8974	453	2	digital	digital	ADJ
fnp-8974	453	3	pathology	pathology	NOUN
fnp-8974	453	4	tools	tool	NOUN
fnp-8974	453	5	and	and	CCONJ
fnp-8974	453	6	vcan	vcan	ADJ
fnp-8974	453	7	immunohistochemistry	immunohistochemistry	NOUN
fnp-8974	453	8	,	,	PUNCT
fnp-8974	453	9	we	we	PRON
fnp-8974	453	10	demonstrated	demonstrate	VERB
fnp-8974	453	11	that	that	SCONJ
fnp-8974	453	12	discrepant	discrepant	ADJ
fnp-8974	453	13	cases	case	NOUN
fnp-8974	453	14	frequently	frequently	ADV
fnp-8974	453	15	contain	contain	VERB
fnp-8974	453	16	myxoid	myxoid	ADJ
fnp-8974	453	17	foci	focus	NOUN
fnp-8974	453	18	.	.	PUNCT
fnp-8974	454	1	67	67	NUM
fnp-8974	454	2	cases	case	NOUN
fnp-8974	454	3	that	that	PRON
fnp-8974	454	4	were	be	AUX
fnp-8974	454	5	not	not	PART
fnp-8974	454	6	in	in	ADP
fnp-8974	454	7	the	the	DET
fnp-8974	454	8	training	training	NOUN
fnp-8974	454	9	cohort	cohort	NOUN
fnp-8974	454	10	of	of	ADP
fnp-8974	454	11	hetairos	hetairo	NOUN
fnp-8974	454	12	,	,	PUNCT
fnp-8974	454	13	an	an	DET
fnp-8974	454	14	ai	ai	VERB
fnp-8974	454	15	-	-	PUNCT
fnp-8974	454	16	assisted	assist	VERB
fnp-8974	454	17	morphology	morphology	NOUN
fnp-8974	454	18	tool	tool	NOUN
fnp-8974	454	19	,	,	PUNCT
fnp-8974	454	20	were	be	AUX
fnp-8974	454	21	evaluated	evaluate	VERB
fnp-8974	454	22	.	.	PUNCT
fnp-8974	455	1	16	16	NUM
fnp-8974	455	2	of	of	ADP
fnp-8974	455	3	the	the	DET
fnp-8974	455	4	17	17	NUM
fnp-8974	455	5	discrepant	discrepant	NOUN
fnp-8974	455	6	cases	case	NOUN
fnp-8974	455	7	(	(	PUNCT
fnp-8974	455	8	94	94	NUM
fnp-8974	455	9	 	 	SPACE
fnp-8974	455	10	%	%	NOUN
fnp-8974	455	11	)	)	PUNCT
fnp-8974	455	12	had	have	VERB
fnp-8974	455	13	a	a	DET
fnp-8974	455	14	prediction	prediction	NOUN
fnp-8974	455	15	for	for	ADP
fnp-8974	455	16	mpe	mpe	PROPN
fnp-8974	455	17	.	.	PUNCT
fnp-8974	456	1	conclusion(s	conclusion(s	NOUN
fnp-8974	456	2	):	):	PUNCT
fnp-8974	456	3	the	the	DET
fnp-8974	456	4	different	different	ADJ
fnp-8974	456	5	layers	layer	NOUN
fnp-8974	456	6	of	of	ADP
fnp-8974	456	7	information	information	NOUN
fnp-8974	456	8	demonstrated	demonstrate	VERB
fnp-8974	456	9	that	that	SCONJ
fnp-8974	456	10	discrepant	discrepant	ADJ
fnp-8974	456	11	cases	case	NOUN
fnp-8974	456	12	show	show	VERB
fnp-8974	456	13	a	a	DET
fnp-8974	456	14	pattern	pattern	NOUN
fnp-8974	456	15	more	more	ADV
fnp-8974	456	16	similar	similar	ADJ
fnp-8974	456	17	to	to	ADP
fnp-8974	456	18	mpe	mpe	X
fnp-8974	456	19	.	.	PUNCT
fnp-8974	457	1	we	we	PRON
fnp-8974	457	2	therefore	therefore	ADV
fnp-8974	457	3	propose	propose	VERB
fnp-8974	457	4	classifying	classify	VERB
fnp-8974	457	5	tumors	tumor	NOUN
fnp-8974	457	6	that	that	PRON
fnp-8974	457	7	resemble	resemble	VERB
fnp-8974	457	8	morphologically	morphologically	ADV
fnp-8974	457	9	spe	spe	ADV
fnp-8974	457	10	but	but	CCONJ
fnp-8974	457	11	exhibit	exhibit	VERB
fnp-8974	457	12	a	a	DET
fnp-8974	457	13	mcmpe	mcmpe	NOUN
fnp-8974	457	14	profile	profile	NOUN
fnp-8974	457	15	or	or	CCONJ
fnp-8974	457	16	with	with	ADP
fnp-8974	457	17	nuclear	nuclear	ADJ
fnp-8974	457	18	expression	expression	NOUN
fnp-8974	457	19	of	of	ADP
fnp-8974	457	20	hoxb13	hoxb13	NOUN
fnp-8974	457	21	as	as	ADP
fnp-8974	457	22	mpe	mpe	X
fnp-8974	457	23	irrespective	irrespective	ADV
fnp-8974	457	24	of	of	ADP
fnp-8974	457	25	their	their	PRON
fnp-8974	457	26	morphological	morphological	ADJ
fnp-8974	457	27	appearance	appearance	NOUN
fnp-8974	457	28	.	.	PUNCT
fnp-8974	458	1	p35	p35	NOUN
fnp-8974	458	2	free	free	ADJ
fnp-8974	458	3	neuropathol	neuropathol	NOUN
fnp-8974	458	4	6:17:53	6:17:53	NUM
fnp-8974	458	5	addressing	address	VERB
fnp-8974	458	6	mgmt	mgmt	NOUN
fnp-8974	458	7	activity	activity	NOUN
fnp-8974	458	8	in	in	ADP
fnp-8974	458	9	glial	glial	ADJ
fnp-8974	458	10	cell	cell	NOUN
fnp-8974	458	11	lines	line	NOUN
fnp-8974	458	12	helene	helene	PROPN
fnp-8974	458	13	blatt1	blatt1	PROPN
fnp-8974	458	14	,	,	PUNCT
fnp-8974	458	15	julia	julia	PROPN
fnp-8974	458	16	kettern1	kettern1	PROPN
fnp-8974	458	17	,	,	PUNCT
fnp-8974	458	18	walter	walter	PROPN
fnp-8974	458	19	j.	j.	PROPN
fnp-8974	458	20	schulz	schulz	PROPN
fnp-8974	458	21	-	-	PUNCT
fnp-8974	458	22	schaeffer1	schaeffer1	PROPN
fnp-8974	458	23	1	1	NUM
fnp-8974	458	24	universität	universität	PROPN
fnp-8974	458	25	des	des	X
fnp-8974	458	26	saarlandes	saarlande	NOUN
fnp-8974	458	27	,	,	PUNCT
fnp-8974	458	28	medizinische	medizinische	PROPN
fnp-8974	458	29	fakultät	fakultät	NOUN
fnp-8974	458	30	,	,	PUNCT
fnp-8974	458	31	institut	institut	PROPN
fnp-8974	458	32	für	für	PROPN
fnp-8974	458	33	neuropathologie	neuropathologie	PROPN
fnp-8974	458	34	,	,	PUNCT
fnp-8974	458	35	homburg	homburg	PROPN
fnp-8974	458	36	,	,	PUNCT
fnp-8974	458	37	germany	germany	PROPN
fnp-8974	458	38	the	the	DET
fnp-8974	458	39	silencing	silencing	NOUN
fnp-8974	458	40	of	of	ADP
fnp-8974	458	41	the	the	DET
fnp-8974	458	42	o6	o6	NOUN
fnp-8974	458	43	-	-	PUNCT
fnp-8974	458	44	methylguanine	methylguanine	NOUN
fnp-8974	458	45	-	-	PUNCT
fnp-8974	458	46	dna	dna	NOUN
fnp-8974	458	47	methyltransferase	methyltransferase	NOUN
fnp-8974	458	48	(	(	PUNCT
fnp-8974	458	49	mgmt	mgmt	PROPN
fnp-8974	458	50	)	)	PUNCT
fnp-8974	458	51	by	by	ADP
fnp-8974	458	52	methylation	methylation	NOUN
fnp-8974	458	53	of	of	ADP
fnp-8974	458	54	its	its	PRON
fnp-8974	458	55	promoter	promoter	NOUN
fnp-8974	458	56	is	be	AUX
fnp-8974	458	57	the	the	DET
fnp-8974	458	58	most	most	ADV
fnp-8974	458	59	important	important	ADJ
fnp-8974	458	60	predictive	predictive	ADJ
fnp-8974	458	61	marker	marker	NOUN
fnp-8974	458	62	for	for	ADP
fnp-8974	458	63	the	the	DET
fnp-8974	458	64	current	current	ADJ
fnp-8974	458	65	standard	standard	ADJ
fnp-8974	458	66	chemotherapy	chemotherapy	NOUN
fnp-8974	458	67	in	in	ADP
fnp-8974	458	68	malignant	malignant	ADJ
fnp-8974	458	69	glioma	glioma	NOUN
fnp-8974	458	70	.	.	PUNCT
fnp-8974	459	1	however	however	ADV
fnp-8974	459	2	,	,	PUNCT
fnp-8974	459	3	methylation	methylation	NOUN
fnp-8974	459	4	detection	detection	NOUN
fnp-8974	459	5	is	be	AUX
fnp-8974	459	6	indirect	indirect	ADJ
fnp-8974	459	7	and	and	CCONJ
fnp-8974	459	8	other	other	ADJ
fnp-8974	459	9	parameters	parameter	NOUN
fnp-8974	459	10	may	may	AUX
fnp-8974	459	11	contribute	contribute	VERB
fnp-8974	459	12	.	.	PUNCT
fnp-8974	460	1	therefore	therefore	ADV
fnp-8974	460	2	,	,	PUNCT
fnp-8974	460	3	it	it	PRON
fnp-8974	460	4	is	be	AUX
fnp-8974	460	5	our	our	PRON
fnp-8974	460	6	objective	objective	NOUN
fnp-8974	460	7	to	to	PART
fnp-8974	460	8	establish	establish	VERB
fnp-8974	460	9	a	a	DET
fnp-8974	460	10	method	method	NOUN
fnp-8974	460	11	for	for	ADP
fnp-8974	460	12	the	the	DET
fnp-8974	460	13	direct	direct	ADJ
fnp-8974	460	14	detection	detection	NOUN
fnp-8974	460	15	of	of	ADP
fnp-8974	460	16	mgmt	mgmt	ADJ
fnp-8974	460	17	activity	activity	NOUN
fnp-8974	460	18	in	in	ADP
fnp-8974	460	19	different	different	ADJ
fnp-8974	460	20	samples	sample	NOUN
fnp-8974	460	21	using	use	VERB
fnp-8974	460	22	synthetic	synthetic	ADJ
fnp-8974	460	23	methylated	methylate	VERB
fnp-8974	460	24	oligonucleotides	oligonucleotide	NOUN
fnp-8974	460	25	.	.	PUNCT
fnp-8974	461	1	for	for	ADP
fnp-8974	461	2	our	our	PRON
fnp-8974	461	3	method	method	NOUN
fnp-8974	461	4	validation	validation	NOUN
fnp-8974	461	5	we	we	PRON
fnp-8974	461	6	chose	choose	VERB
fnp-8974	461	7	commercial	commercial	ADJ
fnp-8974	461	8	glioblastoma	glioblastoma	NOUN
fnp-8974	461	9	cell	cell	NOUN
fnp-8974	461	10	lines	line	NOUN
fnp-8974	461	11	(	(	PUNCT
fnp-8974	461	12	t98	t98	NOUN
fnp-8974	461	13	g	g	NOUN
fnp-8974	461	14	,	,	PUNCT
fnp-8974	461	15	u-87	u-87	PROPN
fnp-8974	461	16	mg	mg	PROPN
fnp-8974	461	17	)	)	PUNCT
fnp-8974	461	18	and	and	CCONJ
fnp-8974	461	19	the	the	DET
fnp-8974	461	20	mgmt	mgmt	NOUN
fnp-8974	461	21	knock	knock	VERB
fnp-8974	461	22	-	-	PUNCT
fnp-8974	461	23	out	out	ADP
fnp-8974	461	24	cell	cell	NOUN
fnp-8974	461	25	line	line	NOUN
fnp-8974	461	26	hap1	hap1	NOUN
fnp-8974	461	27	to	to	PART
fnp-8974	461	28	test	test	VERB
fnp-8974	461	29	their	their	PRON
fnp-8974	461	30	suitability	suitability	NOUN
fnp-8974	461	31	as	as	ADP
fnp-8974	461	32	general	general	ADJ
fnp-8974	461	33	models	model	NOUN
fnp-8974	461	34	for	for	ADP
fnp-8974	461	35	glioma	glioma	NOUN
fnp-8974	461	36	before	before	ADP
fnp-8974	461	37	transitioning	transition	VERB
fnp-8974	461	38	to	to	ADP
fnp-8974	461	39	patient	patient	ADJ
fnp-8974	461	40	samples	sample	NOUN
fnp-8974	461	41	.	.	PUNCT
fnp-8974	462	1	we	we	PRON
fnp-8974	462	2	characterized	characterize	VERB
fnp-8974	462	3	them	they	PRON
fnp-8974	462	4	using	use	VERB
fnp-8974	462	5	our	our	PRON
fnp-8974	462	6	molecular	molecular	ADJ
fnp-8974	462	7	diagnostics	diagnostic	NOUN
fnp-8974	462	8	standard	standard	ADJ
fnp-8974	462	9	panel	panel	NOUN
fnp-8974	462	10	for	for	ADP
fnp-8974	462	11	gliomas	glioma	NOUN
fnp-8974	462	12	,	,	PUNCT
fnp-8974	462	13	which	which	PRON
fnp-8974	462	14	,	,	PUNCT
fnp-8974	462	15	among	among	ADP
fnp-8974	462	16	others	other	NOUN
fnp-8974	462	17	,	,	PUNCT
fnp-8974	462	18	includes	include	VERB
fnp-8974	462	19	mgmt	mgmt	NOUN
fnp-8974	462	20	analysis	analysis	NOUN
fnp-8974	462	21	by	by	ADP
fnp-8974	462	22	pyrosequencing	pyrosequencing	NOUN
fnp-8974	462	23	and	and	CCONJ
fnp-8974	462	24	methylation	methylation	NOUN
fnp-8974	462	25	-	-	PUNCT
fnp-8974	462	26	specific	specific	ADJ
fnp-8974	462	27	-	-	PUNCT
fnp-8974	462	28	pcr	pcr	NOUN
fnp-8974	462	29	.	.	PUNCT
fnp-8974	463	1	additionally	additionally	ADV
fnp-8974	463	2	,	,	PUNCT
fnp-8974	463	3	we	we	PRON
fnp-8974	463	4	performed	perform	VERB
fnp-8974	463	5	qpcr	qpcr	ADJ
fnp-8974	463	6	and	and	CCONJ
fnp-8974	463	7	western	western	ADJ
fnp-8974	463	8	blot	blot	NOUN
fnp-8974	463	9	.	.	PUNCT
fnp-8974	464	1	simultaneously	simultaneously	ADV
fnp-8974	464	2	,	,	PUNCT
fnp-8974	464	3	we	we	PRON
fnp-8974	464	4	quantified	quantify	VERB
fnp-8974	464	5	the	the	DET
fnp-8974	464	6	demethylation	demethylation	NOUN
fnp-8974	464	7	activity	activity	NOUN
fnp-8974	464	8	of	of	ADP
fnp-8974	464	9	recombinant	recombinant	ADJ
fnp-8974	464	10	mgmt	mgmt	NOUN
fnp-8974	464	11	and	and	CCONJ
fnp-8974	464	12	cell	cell	NOUN
fnp-8974	464	13	extracts	extract	NOUN
fnp-8974	464	14	using	use	VERB
fnp-8974	464	15	reverse	reverse	NOUN
fnp-8974	464	16	-	-	PUNCT
fnp-8974	464	17	phase	phase	NOUN
fnp-8974	464	18	liquid	liquid	ADJ
fnp-8974	464	19	chromatography	chromatography	NOUN
fnp-8974	464	20	(	(	PUNCT
fnp-8974	464	21	lc	lc	PROPN
fnp-8974	464	22	)	)	PUNCT
fnp-8974	464	23	.	.	PUNCT
fnp-8974	465	1	our	our	PRON
fnp-8974	465	2	analysis	analysis	NOUN
fnp-8974	465	3	revealed	reveal	VERB
fnp-8974	465	4	that	that	SCONJ
fnp-8974	465	5	both	both	DET
fnp-8974	465	6	cell	cell	NOUN
fnp-8974	465	7	lines	line	NOUN
fnp-8974	465	8	show	show	VERB
fnp-8974	465	9	genetic	genetic	ADJ
fnp-8974	465	10	markers	marker	NOUN
fnp-8974	465	11	which	which	PRON
fnp-8974	465	12	classify	classify	VERB
fnp-8974	465	13	according	accord	VERB
fnp-8974	465	14	to	to	ADP
fnp-8974	465	15	who	who	PRON
fnp-8974	465	16	as	as	ADP
fnp-8974	465	17	a	a	DET
fnp-8974	465	18	grade	grade	NOUN
fnp-8974	465	19	4	4	NUM
fnp-8974	465	20	glioblastoma	glioblastoma	NOUN
fnp-8974	465	21	.	.	PUNCT
fnp-8974	466	1	by	by	ADP
fnp-8974	466	2	pyrosequencing	pyrosequence	VERB
fnp-8974	466	3	,	,	PUNCT
fnp-8974	466	4	mgmt	mgmt	NOUN
fnp-8974	466	5	-	-	PUNCT
fnp-8974	466	6	promotor	promotor	NOUN
fnp-8974	466	7	-	-	PUNCT
fnp-8974	466	8	methylation	methylation	NOUN
fnp-8974	466	9	in	in	ADP
fnp-8974	466	10	hap1	hap1	PROPN
fnp-8974	466	11	was	be	AUX
fnp-8974	466	12	~10	~10	ADJ
fnp-8974	466	13	 	 	SPACE
fnp-8974	466	14	%	%	NOUN
fnp-8974	466	15	,	,	PUNCT
fnp-8974	466	16	t98	t98	VERB
fnp-8974	466	17	g	g	PROPN
fnp-8974	466	18	31	31	NUM
fnp-8974	466	19	 	 	SPACE
fnp-8974	466	20	%	%	NOUN
fnp-8974	466	21	and	and	CCONJ
fnp-8974	466	22	u-87	u-87	ADJ
fnp-8974	466	23	mg	mg	PROPN
fnp-8974	466	24	54	54	NUM
fnp-8974	466	25	 	 	SPACE
fnp-8974	466	26	%	%	NOUN
fnp-8974	466	27	.	.	PUNCT
fnp-8974	467	1	qpcr	qpcr	ADV
fnp-8974	467	2	confirmed	confirm	VERB
fnp-8974	467	3	successful	successful	ADJ
fnp-8974	467	4	knock	knock	NOUN
fnp-8974	467	5	-	-	PUNCT
fnp-8974	467	6	out	out	NOUN
fnp-8974	467	7	and	and	CCONJ
fnp-8974	467	8	no	no	DET
fnp-8974	467	9	detectable	detectable	ADJ
fnp-8974	467	10	mgmt	mgmt	NOUN
fnp-8974	467	11	-	-	PUNCT
fnp-8974	467	12	mrna	mrna	PROPN
fnp-8974	467	13	in	in	ADP
fnp-8974	467	14	u-87	u-87	PROPN
fnp-8974	467	15	mg	mg	PROPN
fnp-8974	467	16	,	,	PUNCT
fnp-8974	467	17	but	but	CCONJ
fnp-8974	467	18	in	in	ADP
fnp-8974	467	19	t98	t98	PROPN
fnp-8974	467	20	g.	g.	PROPN
fnp-8974	467	21	western	western	PROPN
fnp-8974	467	22	blot	blot	PROPN
fnp-8974	467	23	confirmed	confirm	VERB
fnp-8974	467	24	these	these	DET
fnp-8974	467	25	results	result	NOUN
fnp-8974	467	26	.	.	PUNCT
fnp-8974	468	1	the	the	DET
fnp-8974	468	2	lc	lc	NOUN
fnp-8974	468	3	-	-	PUNCT
fnp-8974	468	4	method	method	NOUN
fnp-8974	468	5	was	be	AUX
fnp-8974	468	6	developed	develop	VERB
fnp-8974	468	7	and	and	CCONJ
fnp-8974	468	8	optimized	optimize	VERB
fnp-8974	468	9	with	with	ADP
fnp-8974	468	10	(	(	PUNCT
fnp-8974	468	11	un)methylated	un)methylate	VERB
fnp-8974	468	12	standards	standard	NOUN
fnp-8974	468	13	and	and	CCONJ
fnp-8974	468	14	validated	validate	VERB
fnp-8974	468	15	using	use	VERB
fnp-8974	468	16	recombinant	recombinant	ADJ
fnp-8974	468	17	mgmt	mgmt	NOUN
fnp-8974	468	18	:	:	PUNCT
fnp-8974	468	19	methylated	methylate	VERB
fnp-8974	468	20	oligonucleotides	oligonucleotide	NOUN
fnp-8974	468	21	(	(	PUNCT
fnp-8974	468	22	substrate	substrate	NOUN
fnp-8974	468	23	)	)	PUNCT
fnp-8974	468	24	can	can	AUX
fnp-8974	468	25	be	be	AUX
fnp-8974	468	26	well	well	ADV
fnp-8974	468	27	separated	separate	VERB
fnp-8974	468	28	from	from	ADP
fnp-8974	468	29	its	its	PRON
fnp-8974	468	30	demethylated	demethylated	ADJ
fnp-8974	468	31	counterparts	counterpart	NOUN
fnp-8974	468	32	(	(	PUNCT
fnp-8974	468	33	product	product	NOUN
fnp-8974	468	34	)	)	PUNCT
fnp-8974	468	35	in	in	ADP
fnp-8974	468	36	submicromolar	submicromolar	ADJ
fnp-8974	468	37	ranges	range	NOUN
fnp-8974	468	38	.	.	PUNCT
fnp-8974	469	1	we	we	PRON
fnp-8974	469	2	currently	currently	ADV
fnp-8974	469	3	test	test	VERB
fnp-8974	469	4	cellular	cellular	ADJ
fnp-8974	469	5	extracts	extract	NOUN
fnp-8974	469	6	with	with	ADP
fnp-8974	469	7	differing	differ	VERB
fnp-8974	469	8	mgmt	mgmt	NOUN
fnp-8974	469	9	amounts	amount	NOUN
fnp-8974	469	10	to	to	ADP
fnp-8974	469	11	mimic	mimic	ADJ
fnp-8974	469	12	complex	complex	ADJ
fnp-8974	469	13	samples	sample	NOUN
fnp-8974	469	14	.	.	PUNCT
fnp-8974	470	1	a	a	DET
fnp-8974	470	2	successful	successful	ADJ
fnp-8974	470	3	transfer	transfer	NOUN
fnp-8974	470	4	to	to	ADP
fnp-8974	470	5	patient	patient	ADJ
fnp-8974	470	6	samples	sample	NOUN
fnp-8974	470	7	can	can	AUX
fnp-8974	470	8	support	support	VERB
fnp-8974	470	9	therapy	therapy	NOUN
fnp-8974	470	10	decision	decision	NOUN
fnp-8974	470	11	using	use	VERB
fnp-8974	470	12	mgmt	mgmt	NOUN
fnp-8974	470	13	as	as	ADP
fnp-8974	470	14	a	a	DET
fnp-8974	470	15	biomarker	biomarker	NOUN
fnp-8974	470	16	.	.	PUNCT
fnp-8974	471	1	p36	p36	NOUN
fnp-8974	471	2	free	free	ADJ
fnp-8974	471	3	neuropathol	neuropathol	NOUN
fnp-8974	471	4	6:17:54	6:17:54	NUM
fnp-8974	471	5	loss	loss	NOUN
fnp-8974	471	6	of	of	ADP
fnp-8974	471	7	global	global	ADJ
fnp-8974	471	8	dna	dna	PROPN
fnp-8974	471	9	methylation	methylation	NOUN
fnp-8974	471	10	is	be	AUX
fnp-8974	471	11	prognostic	prognostic	ADJ
fnp-8974	471	12	in	in	ADP
fnp-8974	471	13	oligodendrogliomas	oligodendroglioma	NOUN
fnp-8974	471	14	felix	felix	PROPN
fnp-8974	471	15	hinz1,2	hinz1,2	PROPN
fnp-8974	471	16	,	,	PUNCT
fnp-8974	471	17	dennis	dennis	PROPN
fnp-8974	471	18	friedel1,2,3	friedel1,2,3	PROPN
fnp-8974	471	19	,	,	PUNCT
fnp-8974	471	20	franziska	franziska	PROPN
fnp-8974	471	21	maria	maria	PROPN
fnp-8974	471	22	ippen2,4,5	ippen2,4,5	PROPN
fnp-8974	471	23	,	,	PUNCT
fnp-8974	471	24	martin	martin	PROPN
fnp-8974	471	25	sill6,7	sill6,7	PROPN
fnp-8974	471	26	,	,	PUNCT
fnp-8974	471	27	andrey	andrey	PROPN
fnp-8974	471	28	korshunov1,2,6	korshunov1,2,6	PROPN
fnp-8974	471	29	,	,	PUNCT
fnp-8974	471	30	leonille	leonille	PROPN
fnp-8974	471	31	schweizer8,9,10,11	schweizer8,9,10,11	PROPN
fnp-8974	471	32	,	,	PUNCT
fnp-8974	471	33	daniel	daniel	PROPN
fnp-8974	471	34	schrimpf1,2	schrimpf1,2	PROPN
fnp-8974	471	35	,	,	PUNCT
fnp-8974	471	36	kirsten	kirsten	PROPN
fnp-8974	471	37	göbel1,2	göbel1,2	PROPN
fnp-8974	471	38	,	,	PUNCT
fnp-8974	471	39	fuat	fuat	PROPN
fnp-8974	471	40	aras1,2	aras1,2	PROPN
fnp-8974	471	41	,	,	PUNCT
fnp-8974	471	42	lukas	lukas	PROPN
fnp-8974	471	43	s	s	PROPN
fnp-8974	471	44	friedrich1,2	friedrich1,2	PROPN
fnp-8974	471	45	,	,	PUNCT
fnp-8974	471	46	henri	henri	PROPN
fnp-8974	471	47	bogumil1,2	bogumil1,2	PROPN
fnp-8974	471	48	,	,	PUNCT
fnp-8974	471	49	rouzbeh	rouzbeh	ADJ
fnp-8974	471	50	banan1,2	banan1,2	PROPN
fnp-8974	471	51	,	,	PUNCT
fnp-8974	471	52	hildegard	hildegard	NOUN
fnp-8974	471	53	dohmen12	dohmen12	PROPN
fnp-8974	471	54	,	,	PUNCT
fnp-8974	471	55	sebastian	sebastian	PROPN
fnp-8974	471	56	brandner13,14	brandner13,14	PROPN
fnp-8974	471	57	,	,	PUNCT
fnp-8974	471	58	simone	simone	NOUN
fnp-8974	471	59	schmid15,16	schmid15,16	VERB
fnp-8974	471	60	,	,	PUNCT
fnp-8974	471	61	david	david	PROPN
fnp-8974	471	62	capper15,16	capper15,16	PROPN
fnp-8974	471	63	,	,	PUNCT
fnp-8974	471	64	niklas	niklas	PROPN
fnp-8974	471	65	grassl17,18,19	grassl17,18,19	PROPN
fnp-8974	471	66	,	,	PUNCT
fnp-8974	471	67	henning	henning	PROPN
fnp-8974	471	68	b	b	PROPN
fnp-8974	471	69	boldt20	boldt20	PROPN
fnp-8974	471	70	,	,	PUNCT
fnp-8974	471	71	pieter	pieter	PROPN
fnp-8974	471	72	wesseling21,22	wesseling21,22	PROPN
fnp-8974	471	73	,	,	PUNCT
fnp-8974	471	74	sybren	sybren	PROPN
fnp-8974	471	75	l.	l.	PROPN
fnp-8974	471	76	n.	n.	PROPN
fnp-8974	471	77	maas23,24	maas23,24	PROPN
fnp-8974	471	78	,	,	PUNCT
fnp-8974	471	79	juan	juan	PROPN
fnp-8974	471	80	pablo	pablo	PROPN
fnp-8974	471	81	garces	garces	PROPN
fnp-8974	471	82	martinez25	martinez25	PROPN
fnp-8974	471	83	,	,	PUNCT
fnp-8974	471	84	christine	christine	PROPN
fnp-8974	471	85	stadelmann	stadelmann	PROPN
fnp-8974	471	86	-	-	PUNCT
fnp-8974	471	87	nessler25	nessler25	NOUN
fnp-8974	471	88	,	,	PUNCT
fnp-8974	471	89	guido	guido	NOUN
fnp-8974	471	90	reifenberger26	reifenberger26	NOUN
fnp-8974	471	91	,	,	PUNCT
fnp-8974	471	92	thomas	thomas	PROPN
fnp-8974	471	93	stehle27	stehle27	PROPN
fnp-8974	471	94	,	,	PUNCT
fnp-8974	471	95	alonso	alonso	PROPN
fnp-8974	471	96	barrantes	barrante	NOUN
fnp-8974	471	97	-	-	PUNCT
fnp-8974	471	98	freer28	freer28	NOUN
fnp-8974	471	99	,	,	PUNCT
fnp-8974	471	100	tareq	tareq	PROPN
fnp-8974	471	101	juratli29	juratli29	PROPN
fnp-8974	471	102	,	,	PUNCT
fnp-8974	471	103	stefan	stefan	PROPN
fnp-8974	471	104	pusch1,2	pusch1,2	PROPN
fnp-8974	471	105	,	,	PUNCT
fnp-8974	471	106	daniel	daniel	PROPN
fnp-8974	471	107	haag1	haag1	PROPN
fnp-8974	471	108	,	,	PUNCT
fnp-8974	471	109	david	david	PROPN
fnp-8974	471	110	reuss1,2	reuss1,2	PROPN
fnp-8974	471	111	,	,	PUNCT
fnp-8974	471	112	christel	christel	PROPN
fnp-8974	471	113	herold	herold	PROPN
fnp-8974	471	114	-	-	PUNCT
fnp-8974	471	115	mende30	mende30	PROPN
fnp-8974	471	116	,	,	PUNCT
fnp-8974	471	117	sandro	sandro	PROPN
fnp-8974	471	118	m.	m.	PROPN
fnp-8974	471	119	krieg30	krieg30	PROPN
fnp-8974	471	120	,	,	PUNCT
fnp-8974	471	121	wolfgang	wolfgang	PROPN
fnp-8974	471	122	wick4,5,31	wick4,5,31	PROPN
fnp-8974	471	123	,	,	PUNCT
fnp-8974	471	124	nima	nima	PROPN
fnp-8974	471	125	etminan32	etminan32	PROPN
fnp-8974	471	126	,	,	PUNCT
fnp-8974	471	127	michael	michael	PROPN
fnp-8974	471	128	platten17,18,19,33,34	platten17,18,19,33,34	PROPN
fnp-8974	471	129	,	,	PUNCT
fnp-8974	471	130	stefan	stefan	PROPN
fnp-8974	471	131	pfister4,6,7,35	pfister4,6,7,35	PROPN
fnp-8974	471	132	,	,	PUNCT
fnp-8974	471	133	david	david	PROPN
fnp-8974	471	134	jones4,6,36	jones4,6,36	PROPN
fnp-8974	471	135	,	,	PUNCT
fnp-8974	471	136	felix	felix	PROPN
fnp-8974	471	137	sahm1,2,6	sahm1,2,6	PROPN
fnp-8974	471	138	,	,	PUNCT
fnp-8974	471	139	andreas	andreas	PROPN
fnp-8974	471	140	von	von	PROPN
fnp-8974	471	141	deimling1,2	deimling1,2	PROPN
fnp-8974	471	142	,	,	PUNCT
fnp-8974	472	1	abigail	abigail	PROPN
fnp-8974	472	2	k.	k.	PROPN
fnp-8974	473	1	suwala1,2	suwala1,2	PROPN
fnp-8974	473	2	1	1	NUM
fnp-8974	473	3	dept	dept	NOUN
fnp-8974	473	4	.	.	PROPN
fnp-8974	473	5	of	of	ADP
fnp-8974	473	6	neuropathology	neuropathology	NOUN
fnp-8974	473	7	,	,	PUNCT
fnp-8974	473	8	pathological	pathological	ADJ
fnp-8974	473	9	institute	institute	NOUN
fnp-8974	473	10	,	,	PUNCT
fnp-8974	473	11	heidelberg	heidelberg	PROPN
fnp-8974	473	12	university	university	PROPN
fnp-8974	473	13	hospital	hospital	NOUN
fnp-8974	473	14	,	,	PUNCT
fnp-8974	473	15	heidelberg	heidelberg	PROPN
fnp-8974	473	16	,	,	PUNCT
fnp-8974	473	17	germany	germany	PROPN
fnp-8974	473	18	2	2	NUM
fnp-8974	473	19	clinical	clinical	ADJ
fnp-8974	473	20	cooperation	cooperation	NOUN
fnp-8974	473	21	unit	unit	NOUN
fnp-8974	473	22	neuropathology	neuropathology	NOUN
fnp-8974	473	23	,	,	PUNCT
fnp-8974	473	24	german	german	ADJ
fnp-8974	473	25	consortium	consortium	NOUN
fnp-8974	473	26	for	for	ADP
fnp-8974	473	27	translational	translational	ADJ
fnp-8974	473	28	cancer	cancer	NOUN
fnp-8974	473	29	research	research	NOUN
fnp-8974	473	30	(	(	PUNCT
fnp-8974	473	31	dktk	dktk	NOUN
fnp-8974	473	32	)	)	PUNCT
fnp-8974	473	33	,	,	PUNCT
fnp-8974	473	34	german	german	ADJ
fnp-8974	473	35	cancer	cancer	NOUN
fnp-8974	473	36	research	research	NOUN
fnp-8974	473	37	center	center	NOUN
fnp-8974	473	38	(	(	PUNCT
fnp-8974	473	39	dkfz	dkfz	PROPN
fnp-8974	473	40	)	)	PUNCT
fnp-8974	473	41	,	,	PUNCT
fnp-8974	473	42	heidelberg	heidelberg	PROPN
fnp-8974	473	43	,	,	PUNCT
fnp-8974	473	44	germany	germany	PROPN
fnp-8974	473	45	3	3	NUM
fnp-8974	473	46	faculty	faculty	NOUN
fnp-8974	473	47	of	of	ADP
fnp-8974	473	48	bioscience	bioscience	NOUN
fnp-8974	473	49	,	,	PUNCT
fnp-8974	473	50	heidelberg	heidelberg	PROPN
fnp-8974	473	51	university	university	PROPN
fnp-8974	473	52	,	,	PUNCT
fnp-8974	473	53	heidelberg	heidelberg	PROPN
fnp-8974	473	54	,	,	PUNCT
fnp-8974	473	55	germany	germany	PROPN
fnp-8974	473	56	4	4	NUM
fnp-8974	473	57	national	national	ADJ
fnp-8974	473	58	center	center	NOUN
fnp-8974	473	59	for	for	ADP
fnp-8974	473	60	tumor	tumor	NOUN
fnp-8974	473	61	diseases	disease	NOUN
fnp-8974	473	62	(	(	PUNCT
fnp-8974	473	63	nct	nct	NOUN
fnp-8974	473	64	)	)	PUNCT
fnp-8974	473	65	,	,	PUNCT
fnp-8974	473	66	nct	nct	PROPN
fnp-8974	473	67	heidelberg	heidelberg	PROPN
fnp-8974	473	68	,	,	PUNCT
fnp-8974	473	69	a	a	DET
fnp-8974	473	70	partnership	partnership	NOUN
fnp-8974	473	71	between	between	ADP
fnp-8974	473	72	dkfz	dkfz	NOUN
fnp-8974	473	73	and	and	CCONJ
fnp-8974	473	74	university	university	NOUN
fnp-8974	473	75	hospital	hospital	NOUN
fnp-8974	473	76	heidelberg	heidelberg	PROPN
fnp-8974	473	77	,	,	PUNCT
fnp-8974	473	78	heidelberg	heidelberg	PROPN
fnp-8974	473	79	,	,	PUNCT
fnp-8974	473	80	germany	germany	PROPN
fnp-8974	473	81	5	5	NUM
fnp-8974	473	82	department	department	PROPN
fnp-8974	473	83	of	of	ADP
fnp-8974	473	84	neurology	neurology	NOUN
fnp-8974	473	85	,	,	PUNCT
fnp-8974	473	86	university	university	NOUN
fnp-8974	473	87	hospital	hospital	NOUN
fnp-8974	473	88	heidelberg	heidelberg	PROPN
fnp-8974	473	89	,	,	PUNCT
fnp-8974	473	90	heidelberg	heidelberg	PROPN
fnp-8974	473	91	,	,	PUNCT
fnp-8974	473	92	germany	germany	PROPN
fnp-8974	473	93	6	6	NUM
fnp-8974	473	94	hopp	hopp	PROPN
fnp-8974	473	95	children	children	PROPN
fnp-8974	473	96	's	's	PART
fnp-8974	473	97	cancer	cancer	NOUN
fnp-8974	473	98	center	center	NOUN
fnp-8974	473	99	heidelberg	heidelberg	PROPN
fnp-8974	473	100	(	(	PUNCT
fnp-8974	473	101	kitz	kitz	PROPN
fnp-8974	473	102	)	)	PUNCT
fnp-8974	473	103	,	,	PUNCT
fnp-8974	473	104	heidelberg	heidelberg	PROPN
fnp-8974	473	105	,	,	PUNCT
fnp-8974	473	106	germany	germany	PROPN
fnp-8974	473	107	7	7	NUM
fnp-8974	473	108	division	division	NOUN
fnp-8974	473	109	of	of	ADP
fnp-8974	473	110	pediatric	pediatric	ADJ
fnp-8974	473	111	neurooncology	neurooncology	NOUN
fnp-8974	473	112	,	,	PUNCT
fnp-8974	473	113	german	german	ADJ
fnp-8974	473	114	cancer	cancer	NOUN
fnp-8974	473	115	consortium	consortium	NOUN
fnp-8974	473	116	(	(	PUNCT
fnp-8974	473	117	dktk	dktk	NOUN
fnp-8974	473	118	)	)	PUNCT
fnp-8974	473	119	,	,	PUNCT
fnp-8974	473	120	german	german	ADJ
fnp-8974	473	121	cancer	cancer	NOUN
fnp-8974	473	122	research	research	NOUN
fnp-8974	473	123	center	center	NOUN
fnp-8974	473	124	(	(	PUNCT
fnp-8974	473	125	dkfz	dkfz	PROPN
fnp-8974	473	126	)	)	PUNCT
fnp-8974	473	127	,	,	PUNCT
fnp-8974	473	128	heidelberg	heidelberg	PROPN
fnp-8974	473	129	,	,	PUNCT
fnp-8974	473	130	germany	germany	PROPN
fnp-8974	473	131	8	8	NUM
fnp-8974	473	132	neurological	neurological	ADJ
fnp-8974	473	133	institute	institute	NOUN
fnp-8974	473	134	(	(	PUNCT
fnp-8974	473	135	edinger	edinger	PROPN
fnp-8974	473	136	institute	institute	PROPN
fnp-8974	473	137	)	)	PUNCT
fnp-8974	473	138	,	,	PUNCT
fnp-8974	473	139	goethe	goethe	PROPN
fnp-8974	473	140	university	university	PROPN
fnp-8974	473	141	,	,	PUNCT
fnp-8974	473	142	frankfurt	frankfurt	PROPN
fnp-8974	473	143	am	be	AUX
fnp-8974	473	144	main	main	ADJ
fnp-8974	473	145	,	,	PUNCT
fnp-8974	473	146	germany	germany	PROPN
fnp-8974	473	147	9	9	NUM
fnp-8974	473	148	partner	partner	NOUN
fnp-8974	473	149	site	site	NOUN
fnp-8974	473	150	frankfurt	frankfurt	PROPN
fnp-8974	473	151	,	,	PUNCT
fnp-8974	473	152	and	and	CCONJ
fnp-8974	473	153	german	german	ADJ
fnp-8974	473	154	cancer	cancer	NOUN
fnp-8974	473	155	research	research	NOUN
fnp-8974	473	156	center	center	NOUN
fnp-8974	473	157	(	(	PUNCT
fnp-8974	473	158	dkfz	dkfz	NOUN
fnp-8974	473	159	)	)	PUNCT
fnp-8974	473	160	,	,	PUNCT
fnp-8974	473	161	german	german	ADJ
fnp-8974	473	162	cancer	cancer	NOUN
fnp-8974	473	163	consortium	consortium	NOUN
fnp-8974	473	164	(	(	PUNCT
fnp-8974	473	165	dktk	dktk	NOUN
fnp-8974	473	166	)	)	PUNCT
fnp-8974	473	167	,	,	PUNCT
fnp-8974	473	168	frankfurt	frankfurt	PROPN
fnp-8974	473	169	am	be	AUX
fnp-8974	473	170	main	main	ADJ
fnp-8974	473	171	,	,	PUNCT
fnp-8974	473	172	germany	germany	PROPN
fnp-8974	473	173	10	10	NUM
fnp-8974	473	174	university	university	NOUN
fnp-8974	473	175	cancer	cancer	NOUN
fnp-8974	473	176	center	center	NOUN
fnp-8974	473	177	,	,	PUNCT
fnp-8974	473	178	goethe	goethe	PROPN
fnp-8974	473	179	university	university	PROPN
fnp-8974	473	180	frankfurt	frankfurt	PROPN
fnp-8974	473	181	,	,	PUNCT
fnp-8974	473	182	frankfurt	frankfurt	PROPN
fnp-8974	473	183	am	be	AUX
fnp-8974	473	184	main	main	ADJ
fnp-8974	473	185	,	,	PUNCT
fnp-8974	473	186	germany	germany	PROPN
fnp-8974	473	187	11	11	NUM
fnp-8974	473	188	frankfurt	frankfurt	PROPN
fnp-8974	473	189	cancer	cancer	PROPN
fnp-8974	473	190	institute	institute	PROPN
fnp-8974	473	191	(	(	PUNCT
fnp-8974	473	192	fci	fci	PROPN
fnp-8974	473	193	)	)	PUNCT
fnp-8974	473	194	,	,	PUNCT
fnp-8974	473	195	frankfurt	frankfurt	PROPN
fnp-8974	473	196	am	be	AUX
fnp-8974	473	197	main	main	ADJ
fnp-8974	473	198	,	,	PUNCT
fnp-8974	473	199	germany	germany	PROPN
fnp-8974	473	200	12	12	NUM
fnp-8974	473	201	institute	institute	PROPN
fnp-8974	473	202	of	of	ADP
fnp-8974	473	203	neuropathology	neuropathology	NOUN
fnp-8974	473	204	,	,	PUNCT
fnp-8974	473	205	justus	justus	PROPN
fnp-8974	473	206	-	-	PUNCT
fnp-8974	473	207	liebig	liebig	PROPN
fnp-8974	473	208	university	university	NOUN
fnp-8974	473	209	giessen	giessen	VERB
fnp-8974	473	210	,	,	PUNCT
fnp-8974	473	211	giessen	giessen	VERB
fnp-8974	473	212	,	,	PUNCT
fnp-8974	473	213	germany	germany	PROPN
fnp-8974	473	214	13	13	NUM
fnp-8974	473	215	division	division	NOUN
fnp-8974	473	216	of	of	ADP
fnp-8974	473	217	neuropathology	neuropathology	NOUN
fnp-8974	473	218	,	,	PUNCT
fnp-8974	473	219	national	national	ADJ
fnp-8974	473	220	hospital	hospital	NOUN
fnp-8974	473	221	for	for	ADP
fnp-8974	473	222	neurology	neurology	NOUN
fnp-8974	473	223	and	and	CCONJ
fnp-8974	473	224	neurosurgery	neurosurgery	NOUN
fnp-8974	473	225	,	,	PUNCT
fnp-8974	473	226	university	university	NOUN
fnp-8974	473	227	college	college	NOUN
fnp-8974	473	228	london	london	PROPN
fnp-8974	473	229	hospitals	hospital	NOUN
fnp-8974	473	230	nhs	nhs	PROPN
fnp-8974	473	231	foundation	foundation	PROPN
fnp-8974	473	232	trust	trust	PROPN
fnp-8974	473	233	,	,	PUNCT
fnp-8974	473	234	queen	queen	PROPN
fnp-8974	473	235	square	square	PROPN
fnp-8974	473	236	,	,	PUNCT
fnp-8974	473	237	london	london	PROPN
fnp-8974	473	238	,	,	PUNCT
fnp-8974	473	239	united	united	PROPN
fnp-8974	473	240	kingdom	kingdom	PROPN
fnp-8974	473	241	14	14	NUM
fnp-8974	473	242	department	department	NOUN
fnp-8974	473	243	of	of	ADP
fnp-8974	473	244	neurodegenerative	neurodegenerative	ADJ
fnp-8974	473	245	disease	disease	NOUN
fnp-8974	473	246	,	,	PUNCT
fnp-8974	473	247	ucl	ucl	PROPN
fnp-8974	473	248	queen	queen	PROPN
fnp-8974	473	249	square	square	PROPN
fnp-8974	473	250	institute	institute	PROPN
fnp-8974	473	251	of	of	ADP
fnp-8974	473	252	neurology	neurology	PROPN
fnp-8974	473	253	,	,	PUNCT
fnp-8974	473	254	queen	queen	PROPN
fnp-8974	473	255	square	square	PROPN
fnp-8974	473	256	,	,	PUNCT
fnp-8974	473	257	london	london	PROPN
fnp-8974	473	258	,	,	PUNCT
fnp-8974	473	259	united	united	PROPN
fnp-8974	473	260	kingdom	kingdom	PROPN
fnp-8974	473	261	15	15	NUM
fnp-8974	473	262	department	department	NOUN
fnp-8974	473	263	of	of	ADP
fnp-8974	473	264	neuropathology	neuropathology	NOUN
fnp-8974	473	265	,	,	PUNCT
fnp-8974	473	266	charité	charité	PROPN
fnp-8974	473	267	-	-	PUNCT
fnp-8974	473	268	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	473	269	berlin	berlin	PROPN
fnp-8974	473	270	,	,	PUNCT
fnp-8974	473	271	corporate	corporate	ADJ
fnp-8974	473	272	member	member	NOUN
fnp-8974	473	273	of	of	ADP
fnp-8974	473	274	freie	freie	PROPN
fnp-8974	473	275	universität	universität	PROPN
fnp-8974	473	276	berlin	berlin	PROPN
fnp-8974	473	277	and	and	CCONJ
fnp-8974	473	278	humboldt	humboldt	PROPN
fnp-8974	473	279	-	-	PUNCT
fnp-8974	473	280	universität	universität	PROPN
fnp-8974	473	281	zu	zu	PROPN
fnp-8974	473	282	berlin	berlin	PROPN
fnp-8974	473	283	,	,	PUNCT
fnp-8974	473	284	berlin	berlin	PROPN
fnp-8974	473	285	,	,	PUNCT
fnp-8974	473	286	germany	germany	PROPN
fnp-8974	473	287	16	16	NUM
fnp-8974	473	288	german	german	ADJ
fnp-8974	473	289	cancer	cancer	NOUN
fnp-8974	473	290	consortium	consortium	NOUN
fnp-8974	473	291	(	(	PUNCT
fnp-8974	473	292	dktk	dktk	NOUN
fnp-8974	473	293	)	)	PUNCT
fnp-8974	473	294	,	,	PUNCT
fnp-8974	473	295	partner	partner	NOUN
fnp-8974	473	296	site	site	NOUN
fnp-8974	473	297	berlin	berlin	PROPN
fnp-8974	473	298	,	,	PUNCT
fnp-8974	473	299	german	german	ADJ
fnp-8974	473	300	cancer	cancer	NOUN
fnp-8974	473	301	research	research	NOUN
fnp-8974	473	302	center	center	NOUN
fnp-8974	473	303	(	(	PUNCT
fnp-8974	473	304	dkfz	dkfz	PROPN
fnp-8974	473	305	)	)	PUNCT
fnp-8974	473	306	,	,	PUNCT
fnp-8974	473	307	heidelberg	heidelberg	PROPN
fnp-8974	473	308	,	,	PUNCT
fnp-8974	473	309	germany	germany	PROPN
fnp-8974	473	310	17	17	NUM
fnp-8974	473	311	dktk	dktk	PROPN
fnp-8974	473	312	ccu	ccu	PROPN
fnp-8974	473	313	neuroimmunology	neuroimmunology	PROPN
fnp-8974	473	314	and	and	CCONJ
fnp-8974	473	315	brain	brain	NOUN
fnp-8974	473	316	tumor	tumor	NOUN
fnp-8974	473	317	immunology	immunology	NOUN
fnp-8974	473	318	,	,	PUNCT
fnp-8974	473	319	german	german	ADJ
fnp-8974	473	320	cancer	cancer	NOUN
fnp-8974	473	321	research	research	NOUN
fnp-8974	473	322	center	center	NOUN
fnp-8974	473	323	(	(	PUNCT
fnp-8974	473	324	dkfz	dkfz	PROPN
fnp-8974	473	325	)	)	PUNCT
fnp-8974	473	326	,	,	PUNCT
fnp-8974	473	327	heidelberg	heidelberg	PROPN
fnp-8974	473	328	,	,	PUNCT
fnp-8974	473	329	germany	germany	PROPN
fnp-8974	473	330	18	18	NUM
fnp-8974	473	331	department	department	PROPN
fnp-8974	473	332	of	of	ADP
fnp-8974	473	333	neurology	neurology	NOUN
fnp-8974	473	334	,	,	PUNCT
fnp-8974	473	335	medical	medical	ADJ
fnp-8974	473	336	faculty	faculty	NOUN
fnp-8974	473	337	mannheim	mannheim	PROPN
fnp-8974	473	338	,	,	PUNCT
fnp-8974	473	339	mctn	mctn	PROPN
fnp-8974	473	340	,	,	PUNCT
fnp-8974	473	341	heidelberg	heidelberg	PROPN
fnp-8974	473	342	university	university	PROPN
fnp-8974	473	343	,	,	PUNCT
fnp-8974	473	344	heidelberg	heidelberg	PROPN
fnp-8974	473	345	,	,	PUNCT
fnp-8974	473	346	germany	germany	PROPN
fnp-8974	473	347	19	19	NUM
fnp-8974	473	348	dkfz	dkfz	ADJ
fnp-8974	473	349	-	-	PUNCT
fnp-8974	473	350	hector	hector	NOUN
fnp-8974	473	351	cancer	cancer	NOUN
fnp-8974	473	352	institute	institute	PROPN
fnp-8974	473	353	at	at	ADP
fnp-8974	473	354	university	university	PROPN
fnp-8974	473	355	medical	medical	ADJ
fnp-8974	473	356	center	center	PROPN
fnp-8974	473	357	mannheim	mannheim	PROPN
fnp-8974	473	358	,	,	PUNCT
fnp-8974	473	359	mannheim	mannheim	PROPN
fnp-8974	473	360	,	,	PUNCT
fnp-8974	473	361	germany	germany	PROPN
fnp-8974	473	362	20	20	NUM
fnp-8974	473	363	department	department	NOUN
fnp-8974	473	364	of	of	ADP
fnp-8974	473	365	pathology	pathology	PROPN
fnp-8974	473	366	,	,	PUNCT
fnp-8974	473	367	odense	odense	PROPN
fnp-8974	473	368	university	university	PROPN
fnp-8974	473	369	hospital	hospital	PROPN
fnp-8974	473	370	,	,	PUNCT
fnp-8974	473	371	odense	odense	PROPN
fnp-8974	473	372	,	,	PUNCT
fnp-8974	473	373	denmark	denmark	PROPN
fnp-8974	473	374	21	21	NUM
fnp-8974	473	375	department	department	NOUN
fnp-8974	473	376	of	of	ADP
fnp-8974	473	377	pathology	pathology	PROPN
fnp-8974	473	378	,	,	PUNCT
fnp-8974	473	379	amsterdam	amsterdam	PROPN
fnp-8974	473	380	university	university	PROPN
fnp-8974	473	381	medical	medical	ADJ
fnp-8974	473	382	center	center	NOUN
fnp-8974	473	383	,	,	PUNCT
fnp-8974	473	384	amsterdam	amsterdam	PROPN
fnp-8974	473	385	,	,	PUNCT
fnp-8974	473	386	netherlands	netherlands	PROPN
fnp-8974	473	387	22	22	NUM
fnp-8974	473	388	princess	princess	PROPN
fnp-8974	473	389	máxima	máxima	PROPN
fnp-8974	473	390	center	center	NOUN
fnp-8974	473	391	for	for	ADP
fnp-8974	473	392	pediatric	pediatric	ADJ
fnp-8974	473	393	oncology	oncology	NOUN
fnp-8974	473	394	,	,	PUNCT
fnp-8974	473	395	utrecht	utrecht	PROPN
fnp-8974	473	396	,	,	PUNCT
fnp-8974	473	397	netherlands	netherlands	PROPN
fnp-8974	473	398	23	23	NUM
fnp-8974	473	399	department	department	NOUN
fnp-8974	473	400	of	of	ADP
fnp-8974	473	401	pathology	pathology	PROPN
fnp-8974	473	402	,	,	PUNCT
fnp-8974	473	403	erasmus	erasmus	PROPN
fnp-8974	473	404	mc	mc	PROPN
fnp-8974	473	405	cancer	cancer	PROPN
fnp-8974	473	406	institute	institute	PROPN
fnp-8974	473	407	,	,	PUNCT
fnp-8974	473	408	erasmus	erasmus	PROPN
fnp-8974	473	409	medical	medical	ADJ
fnp-8974	473	410	center	center	PROPN
fnp-8974	473	411	,	,	PUNCT
fnp-8974	473	412	rotterdam	rotterdam	PROPN
fnp-8974	473	413	,	,	PUNCT
fnp-8974	473	414	netherlands	netherlands	PROPN
fnp-8974	473	415	24	24	NUM
fnp-8974	473	416	department	department	PROPN
fnp-8974	473	417	of	of	ADP
fnp-8974	473	418	pathology	pathology	PROPN
fnp-8974	473	419	,	,	PUNCT
fnp-8974	473	420	leiden	leiden	PROPN
fnp-8974	473	421	university	university	PROPN
fnp-8974	473	422	medical	medical	ADJ
fnp-8974	473	423	center	center	NOUN
fnp-8974	473	424	,	,	PUNCT
fnp-8974	473	425	leiden	leiden	PROPN
fnp-8974	473	426	,	,	PUNCT
fnp-8974	473	427	netherlands	netherlands	PROPN
fnp-8974	473	428	25	25	NUM
fnp-8974	473	429	department	department	PROPN
fnp-8974	473	430	of	of	ADP
fnp-8974	473	431	neuropathology	neuropathology	NOUN
fnp-8974	473	432	,	,	PUNCT
fnp-8974	473	433	university	university	NOUN
fnp-8974	473	434	medical	medical	ADJ
fnp-8974	473	435	center	center	NOUN
fnp-8974	473	436	göttingen	göttingen	NOUN
fnp-8974	473	437	,	,	PUNCT
fnp-8974	473	438	göttingen	göttingen	NOUN
fnp-8974	473	439	,	,	PUNCT
fnp-8974	473	440	germany	germany	PROPN
fnp-8974	473	441	26	26	NUM
fnp-8974	473	442	institute	institute	PROPN
fnp-8974	473	443	of	of	ADP
fnp-8974	473	444	neuropathology	neuropathology	NOUN
fnp-8974	473	445	,	,	PUNCT
fnp-8974	473	446	medical	medical	ADJ
fnp-8974	473	447	faculty	faculty	NOUN
fnp-8974	473	448	,	,	PUNCT
fnp-8974	473	449	and	and	CCONJ
fnp-8974	473	450	university	university	NOUN
fnp-8974	473	451	hospital	hospital	NOUN
fnp-8974	473	452	düsseldorf	düsseldorf	PROPN
fnp-8974	473	453	,	,	PUNCT
fnp-8974	473	454	heinrich	heinrich	PROPN
fnp-8974	473	455	heine	heine	PROPN
fnp-8974	473	456	university	university	PROPN
fnp-8974	473	457	,	,	PUNCT
fnp-8974	473	458	and	and	CCONJ
fnp-8974	473	459	german	german	ADJ
fnp-8974	473	460	cancer	cancer	NOUN
fnp-8974	473	461	consortium	consortium	NOUN
fnp-8974	473	462	(	(	PUNCT
fnp-8974	473	463	dktk	dktk	NOUN
fnp-8974	473	464	)	)	PUNCT
fnp-8974	473	465	,	,	PUNCT
fnp-8974	473	466	partner	partner	NOUN
fnp-8974	473	467	site	site	NOUN
fnp-8974	473	468	essen	essen	PROPN
fnp-8974	473	469	/	/	SYM
fnp-8974	473	470	düsseldorf	düsseldorf	PROPN
fnp-8974	473	471	,	,	PUNCT
fnp-8974	473	472	düsseldorf	düsseldorf	PROPN
fnp-8974	473	473	,	,	PUNCT
fnp-8974	473	474	germany	germany	PROPN
fnp-8974	473	475	27	27	NUM
fnp-8974	473	476	institute	institute	NOUN
fnp-8974	473	477	for	for	ADP
fnp-8974	473	478	neuropathology	neuropathology	NOUN
fnp-8974	473	479	,	,	PUNCT
fnp-8974	473	480	faculty	faculty	NOUN
fnp-8974	473	481	of	of	ADP
fnp-8974	473	482	medicine	medicine	NOUN
fnp-8974	473	483	,	,	PUNCT
fnp-8974	473	484	university	university	NOUN
fnp-8974	473	485	hospital	hospital	NOUN
fnp-8974	473	486	cologne	cologne	NOUN
fnp-8974	473	487	,	,	PUNCT
fnp-8974	473	488	cologne	cologne	NOUN
fnp-8974	473	489	,	,	PUNCT
fnp-8974	473	490	germany	germany	PROPN
fnp-8974	473	491	28	28	NUM
fnp-8974	473	492	university	university	PROPN
fnp-8974	473	493	of	of	ADP
fnp-8974	473	494	leipzig	leipzig	PROPN
fnp-8974	473	495	medical	medical	ADJ
fnp-8974	473	496	center	center	NOUN
fnp-8974	473	497	,	,	PUNCT
fnp-8974	473	498	paul	paul	PROPN
fnp-8974	473	499	-	-	PUNCT
fnp-8974	473	500	flechsig	flechsig	PROPN
fnp-8974	473	501	-	-	PUNCT
fnp-8974	473	502	institute	institute	NOUN
fnp-8974	473	503	of	of	ADP
fnp-8974	473	504	neuropathology	neuropathology	NOUN
fnp-8974	473	505	,	,	PUNCT
fnp-8974	473	506	leipzig	leipzig	PROPN
fnp-8974	473	507	,	,	PUNCT
fnp-8974	473	508	germany	germany	PROPN
fnp-8974	473	509	29	29	NUM
fnp-8974	473	510	department	department	PROPN
fnp-8974	473	511	for	for	ADP
fnp-8974	473	512	neurosurgery	neurosurgery	NOUN
fnp-8974	473	513	,	,	PUNCT
fnp-8974	473	514	tu	tu	PROPN
fnp-8974	473	515	dresden	dresden	PROPN
fnp-8974	473	516	university	university	PROPN
fnp-8974	473	517	of	of	ADP
fnp-8974	473	518	technology	technology	PROPN
fnp-8974	473	519	,	,	PUNCT
fnp-8974	473	520	dresden	dresden	PROPN
fnp-8974	473	521	,	,	PUNCT
fnp-8974	473	522	germany	germany	PROPN
fnp-8974	473	523	30	30	NUM
fnp-8974	473	524	department	department	NOUN
fnp-8974	473	525	of	of	ADP
fnp-8974	473	526	neurosurgery	neurosurgery	NOUN
fnp-8974	473	527	,	,	PUNCT
fnp-8974	473	528	heidelberg	heidelberg	PROPN
fnp-8974	473	529	university	university	PROPN
fnp-8974	473	530	hospital	hospital	NOUN
fnp-8974	473	531	,	,	PUNCT
fnp-8974	473	532	heidelberg	heidelberg	PROPN
fnp-8974	473	533	,	,	PUNCT
fnp-8974	473	534	germany	germany	PROPN
fnp-8974	473	535	31	31	NUM
fnp-8974	473	536	clinical	clinical	ADJ
fnp-8974	473	537	cooperation	cooperation	NOUN
fnp-8974	473	538	unit	unit	NOUN
fnp-8974	473	539	neurooncology	neurooncology	NOUN
fnp-8974	473	540	,	,	PUNCT
fnp-8974	473	541	german	german	ADJ
fnp-8974	473	542	consortium	consortium	NOUN
fnp-8974	473	543	for	for	ADP
fnp-8974	473	544	translational	translational	ADJ
fnp-8974	473	545	cancer	cancer	NOUN
fnp-8974	473	546	research	research	NOUN
fnp-8974	473	547	(	(	PUNCT
fnp-8974	473	548	dktk	dktk	NOUN
fnp-8974	473	549	)	)	PUNCT
fnp-8974	473	550	,	,	PUNCT
fnp-8974	473	551	german	german	ADJ
fnp-8974	473	552	cancer	cancer	NOUN
fnp-8974	473	553	research	research	NOUN
fnp-8974	473	554	center	center	NOUN
fnp-8974	473	555	(	(	PUNCT
fnp-8974	473	556	dkfz	dkfz	PROPN
fnp-8974	473	557	)	)	PUNCT
fnp-8974	473	558	,	,	PUNCT
fnp-8974	473	559	heidelberg	heidelberg	PROPN
fnp-8974	473	560	,	,	PUNCT
fnp-8974	473	561	germany	germany	PROPN
fnp-8974	473	562	32	32	NUM
fnp-8974	473	563	department	department	NOUN
fnp-8974	473	564	of	of	ADP
fnp-8974	473	565	neurosurgery	neurosurgery	NOUN
fnp-8974	473	566	,	,	PUNCT
fnp-8974	473	567	heidelberg	heidelberg	PROPN
fnp-8974	473	568	university	university	PROPN
fnp-8974	473	569	,	,	PUNCT
fnp-8974	473	570	mannheim	mannheim	PROPN
fnp-8974	473	571	,	,	PUNCT
fnp-8974	473	572	germany	germany	PROPN
fnp-8974	473	573	33	33	NUM
fnp-8974	473	574	immune	immune	ADJ
fnp-8974	473	575	monitoring	monitoring	NOUN
fnp-8974	473	576	unit	unit	NOUN
fnp-8974	473	577	,	,	PUNCT
fnp-8974	473	578	german	german	ADJ
fnp-8974	473	579	cancer	cancer	NOUN
fnp-8974	473	580	research	research	NOUN
fnp-8974	473	581	center	center	NOUN
fnp-8974	473	582	(	(	PUNCT
fnp-8974	473	583	dkfz	dkfz	ADJ
fnp-8974	473	584	)	)	PUNCT
fnp-8974	473	585	and	and	CCONJ
fnp-8974	473	586	national	national	ADJ
fnp-8974	473	587	center	center	NOUN
fnp-8974	473	588	for	for	ADP
fnp-8974	473	589	tumor	tumor	NOUN
fnp-8974	473	590	diseases	disease	NOUN
fnp-8974	473	591	(	(	PUNCT
fnp-8974	473	592	nct	nct	NOUN
fnp-8974	473	593	)	)	PUNCT
fnp-8974	473	594	,	,	PUNCT
fnp-8974	473	595	heidelberg	heidelberg	PROPN
fnp-8974	473	596	,	,	PUNCT
fnp-8974	473	597	germany	germany	PROPN
fnp-8974	473	598	34	34	NUM
fnp-8974	473	599	helmholtz	helmholtz	PROPN
fnp-8974	473	600	institute	institute	PROPN
fnp-8974	473	601	for	for	ADP
fnp-8974	473	602	translational	translational	ADJ
fnp-8974	473	603	oncology	oncology	NOUN
fnp-8974	473	604	(	(	PUNCT
fnp-8974	473	605	hi	hi	NOUN
fnp-8974	473	606	-	-	PUNCT
fnp-8974	473	607	tron	tron	NOUN
fnp-8974	473	608	)	)	PUNCT
fnp-8974	473	609	mainz	mainz	PROPN
fnp-8974	473	610	,	,	PUNCT
fnp-8974	473	611	german	german	ADJ
fnp-8974	473	612	cancer	cancer	NOUN
fnp-8974	473	613	research	research	NOUN
fnp-8974	473	614	center	center	NOUN
fnp-8974	473	615	,	,	PUNCT
fnp-8974	473	616	mainz	mainz	PROPN
fnp-8974	473	617	,	,	PUNCT
fnp-8974	473	618	germany	germany	PROPN
fnp-8974	473	619	35	35	NUM
fnp-8974	473	620	department	department	NOUN
fnp-8974	473	621	of	of	ADP
fnp-8974	473	622	pediatric	pediatric	ADJ
fnp-8974	473	623	hematology	hematology	NOUN
fnp-8974	473	624	and	and	CCONJ
fnp-8974	473	625	oncology	oncology	NOUN
fnp-8974	473	626	,	,	PUNCT
fnp-8974	473	627	heidelberg	heidelberg	PROPN
fnp-8974	473	628	university	university	PROPN
fnp-8974	473	629	hospital	hospital	NOUN
fnp-8974	473	630	,	,	PUNCT
fnp-8974	473	631	heidelberg	heidelberg	PROPN
fnp-8974	473	632	,	,	PUNCT
fnp-8974	473	633	germany	germany	PROPN
fnp-8974	473	634	36	36	NUM
fnp-8974	473	635	division	division	NOUN
fnp-8974	473	636	of	of	ADP
fnp-8974	473	637	pediatric	pediatric	ADJ
fnp-8974	473	638	glioma	glioma	NOUN
fnp-8974	473	639	research	research	NOUN
fnp-8974	473	640	,	,	PUNCT
fnp-8974	473	641	german	german	ADJ
fnp-8974	473	642	cancer	cancer	NOUN
fnp-8974	473	643	research	research	NOUN
fnp-8974	473	644	center	center	NOUN
fnp-8974	473	645	(	(	PUNCT
fnp-8974	473	646	dkfz	dkfz	PROPN
fnp-8974	473	647	)	)	PUNCT
fnp-8974	473	648	,	,	PUNCT
fnp-8974	473	649	heidelberg	heidelberg	PROPN
fnp-8974	473	650	,	,	PUNCT
fnp-8974	473	651	germany	germany	PROPN
fnp-8974	473	652	background	background	NOUN
fnp-8974	473	653	:	:	PUNCT
fnp-8974	473	654	idh	idh	NOUN
fnp-8974	473	655	-	-	PUNCT
fnp-8974	473	656	mutant	mutant	NOUN
fnp-8974	473	657	gliomas	glioma	NOUN
fnp-8974	473	658	are	be	AUX
fnp-8974	473	659	categorized	categorize	VERB
fnp-8974	473	660	into	into	ADP
fnp-8974	473	661	idh	idh	NOUN
fnp-8974	473	662	-	-	PUNCT
fnp-8974	473	663	mutant	mutant	NOUN
fnp-8974	473	664	astrocytomas	astrocytoma	NOUN
fnp-8974	473	665	(	(	PUNCT
fnp-8974	473	666	cns	cns	X
fnp-8974	473	667	who	who	PRON
fnp-8974	473	668	grades	grade	VERB
fnp-8974	473	669	2	2	NUM
fnp-8974	473	670	,	,	PUNCT
fnp-8974	473	671	3	3	NUM
fnp-8974	473	672	,	,	PUNCT
fnp-8974	473	673	4	4	NUM
fnp-8974	473	674	)	)	PUNCT
fnp-8974	473	675	and	and	CCONJ
fnp-8974	473	676	idh	idh	NOUN
fnp-8974	473	677	-	-	PUNCT
fnp-8974	473	678	mutant	mutant	NOUN
fnp-8974	473	679	,	,	PUNCT
fnp-8974	473	680	1p/19q	1p/19q	NOUN
fnp-8974	473	681	-	-	PUNCT
fnp-8974	473	682	codeleted	codelete	VERB
fnp-8974	473	683	oligodendrogliomas	oligodendroglioma	NOUN
fnp-8974	473	684	(	(	PUNCT
fnp-8974	473	685	cns	cns	X
fnp-8974	473	686	who	who	PRON
fnp-8974	473	687	grades	grade	VERB
fnp-8974	473	688	2	2	NUM
fnp-8974	473	689	,	,	PUNCT
fnp-8974	473	690	3	3	NUM
fnp-8974	473	691	)	)	PUNCT
fnp-8974	473	692	.	.	PUNCT
fnp-8974	474	1	apart	apart	ADV
fnp-8974	474	2	from	from	ADP
fnp-8974	474	3	specific	specific	ADJ
fnp-8974	474	4	subgroups	subgroup	NOUN
fnp-8974	474	5	,	,	PUNCT
fnp-8974	474	6	idh	idh	NOUN
fnp-8974	474	7	-	-	PUNCT
fnp-8974	474	8	mutant	mutant	NOUN
fnp-8974	474	9	and	and	CCONJ
fnp-8974	474	10	1p/19q	1p/19q	NOUN
fnp-8974	474	11	-	-	PUNCT
fnp-8974	474	12	codeleted	codelete	VERB
fnp-8974	474	13	oligodendrogliomas	oligodendroglioma	NOUN
fnp-8974	474	14	are	be	AUX
fnp-8974	474	15	assigned	assign	VERB
fnp-8974	474	16	to	to	ADP
fnp-8974	474	17	a	a	DET
fnp-8974	474	18	single	single	ADJ
fnp-8974	474	19	dna	dna	PROPN
fnp-8974	474	20	methylation	methylation	NOUN
fnp-8974	474	21	class	class	NOUN
fnp-8974	474	22	using	use	VERB
fnp-8974	474	23	the	the	DET
fnp-8974	474	24	heidelberg	heidelberg	NOUN
fnp-8974	474	25	brain	brain	NOUN
fnp-8974	474	26	tumor	tumor	NOUN
fnp-8974	474	27	classifier	classifier	NOUN
fnp-8974	474	28	,	,	PUNCT
fnp-8974	474	29	whereas	whereas	SCONJ
fnp-8974	474	30	idh	idh	NOUN
fnp-8974	474	31	-	-	PUNCT
fnp-8974	474	32	mutant	mutant	NOUN
fnp-8974	474	33	astrocytomas	astrocytoma	NOUN
fnp-8974	474	34	are	be	AUX
fnp-8974	474	35	divided	divide	VERB
fnp-8974	474	36	into	into	ADP
fnp-8974	474	37	two	two	NUM
fnp-8974	474	38	methylation	methylation	NOUN
fnp-8974	474	39	classes	class	NOUN
fnp-8974	474	40	:	:	PUNCT
fnp-8974	474	41	astrocytoma	astrocytoma	NOUN
fnp-8974	474	42	,	,	PUNCT
fnp-8974	474	43	idh	idh	NOUN
fnp-8974	474	44	-	-	PUNCT
fnp-8974	474	45	mutant	mutant	NOUN
fnp-8974	474	46	lower	low	ADJ
fnp-8974	474	47	grade	grade	NOUN
fnp-8974	474	48	and	and	CCONJ
fnp-8974	474	49	astrocytoma	astrocytoma	NOUN
fnp-8974	474	50	,	,	PUNCT
fnp-8974	474	51	idh	idh	NOUN
fnp-8974	474	52	-	-	PUNCT
fnp-8974	474	53	mutant	mutant	ADJ
fnp-8974	474	54	high	high	ADJ
fnp-8974	474	55	grade	grade	NOUN
fnp-8974	474	56	.	.	PUNCT
fnp-8974	475	1	occasionally	occasionally	ADV
fnp-8974	475	2	,	,	PUNCT
fnp-8974	475	3	idh	idh	NOUN
fnp-8974	475	4	-	-	PUNCT
fnp-8974	475	5	mutant	mutant	NOUN
fnp-8974	475	6	and	and	CCONJ
fnp-8974	475	7	1p/19q	1p/19q	NOUN
fnp-8974	475	8	-	-	PUNCT
fnp-8974	475	9	codeleted	codelete	VERB
fnp-8974	475	10	oligodendrogliomas	oligodendroglioma	NOUN
fnp-8974	475	11	are	be	AUX
fnp-8974	475	12	classified	classify	VERB
fnp-8974	475	13	as	as	ADP
fnp-8974	475	14	astrocytomas	astrocytomas	ADJ
fnp-8974	475	15	by	by	ADP
fnp-8974	475	16	methylation	methylation	NOUN
fnp-8974	475	17	profiling	profiling	NOUN
fnp-8974	475	18	despite	despite	SCONJ
fnp-8974	475	19	the	the	DET
fnp-8974	475	20	clear	clear	ADJ
fnp-8974	475	21	presence	presence	NOUN
fnp-8974	475	22	of	of	ADP
fnp-8974	475	23	1p/19q	1p/19q	PROPN
fnp-8974	475	24	codeletion	codeletion	NOUN
fnp-8974	475	25	.	.	PUNCT
fnp-8974	476	1	this	this	DET
fnp-8974	476	2	study	study	NOUN
fnp-8974	476	3	aims	aim	VERB
fnp-8974	476	4	to	to	PART
fnp-8974	476	5	investigate	investigate	VERB
fnp-8974	476	6	the	the	DET
fnp-8974	476	7	significance	significance	NOUN
fnp-8974	476	8	of	of	ADP
fnp-8974	476	9	this	this	DET
fnp-8974	476	10	alternative	alternative	ADJ
fnp-8974	476	11	classification	classification	NOUN
fnp-8974	476	12	.	.	PUNCT
fnp-8974	477	1	method(s	method(	VERB
fnp-8974	477	2	):	):	PUNCT
fnp-8974	477	3	we	we	PRON
fnp-8974	477	4	collected	collect	VERB
fnp-8974	477	5	69	69	NUM
fnp-8974	477	6	idh	idh	NOUN
fnp-8974	477	7	-	-	PUNCT
fnp-8974	477	8	mutant	mutant	NOUN
fnp-8974	477	9	and	and	CCONJ
fnp-8974	477	10	1p/19q	1p/19q	NOUN
fnp-8974	477	11	-	-	PUNCT
fnp-8974	477	12	codeleted	codelete	VERB
fnp-8974	477	13	oligodendrogliomas	oligodendroglioma	NOUN
fnp-8974	477	14	classified	classify	VERB
fnp-8974	477	15	by	by	ADP
fnp-8974	477	16	the	the	DET
fnp-8974	477	17	heidelberg	heidelberg	PROPN
fnp-8974	477	18	brain	brain	NOUN
fnp-8974	477	19	tumor	tumor	NOUN
fnp-8974	477	20	classifier	classifier	NOUN
fnp-8974	477	21	(	(	PUNCT
fnp-8974	477	22	v12.8	v12.8	NOUN
fnp-8974	477	23	)	)	PUNCT
fnp-8974	477	24	as	as	ADP
fnp-8974	477	25	either	either	DET
fnp-8974	477	26	astrocytoma	astrocytoma	NOUN
fnp-8974	477	27	,	,	PUNCT
fnp-8974	477	28	idh	idh	NOUN
fnp-8974	477	29	-	-	PUNCT
fnp-8974	477	30	mutant	mutant	NOUN
fnp-8974	477	31	,	,	PUNCT
fnp-8974	477	32	lower	low	ADJ
fnp-8974	477	33	grade	grade	NOUN
fnp-8974	477	34	or	or	CCONJ
fnp-8974	477	35	high	high	ADJ
fnp-8974	477	36	grade	grade	NOUN
fnp-8974	477	37	.	.	PUNCT
fnp-8974	478	1	methylation	methylation	NOUN
fnp-8974	478	2	data	datum	NOUN
fnp-8974	478	3	were	be	AUX
fnp-8974	478	4	analysed	analyse	VERB
fnp-8974	478	5	for	for	ADP
fnp-8974	478	6	methylation	methylation	NOUN
fnp-8974	478	7	class	class	NOUN
fnp-8974	478	8	assignment	assignment	NOUN
fnp-8974	478	9	and	and	CCONJ
fnp-8974	478	10	deconvoluted	deconvolute	VERB
fnp-8974	478	11	using	use	VERB
fnp-8974	478	12	methylcibersort	methylcibersort	NOUN
fnp-8974	478	13	to	to	PART
fnp-8974	478	14	determine	determine	VERB
fnp-8974	478	15	cell	cell	NOUN
fnp-8974	478	16	type	type	NOUN
fnp-8974	478	17	proportions	proportion	NOUN
fnp-8974	478	18	.	.	PUNCT
fnp-8974	479	1	clinical	clinical	ADJ
fnp-8974	479	2	follow	follow	NOUN
fnp-8974	479	3	-	-	PUNCT
fnp-8974	479	4	up	up	ADP
fnp-8974	479	5	data	datum	NOUN
fnp-8974	479	6	were	be	AUX
fnp-8974	479	7	retrospectively	retrospectively	ADV
fnp-8974	479	8	obtained	obtain	VERB
fnp-8974	479	9	for	for	ADP
fnp-8974	479	10	40	40	NUM
fnp-8974	479	11	of	of	ADP
fnp-8974	479	12	the	the	DET
fnp-8974	479	13	69	69	NUM
fnp-8974	479	14	patients	patient	NOUN
fnp-8974	479	15	.	.	PUNCT
fnp-8974	480	1	result(s	result(s	NOUN
fnp-8974	480	2	):	):	PUNCT
fnp-8974	480	3	idh	idh	NOUN
fnp-8974	480	4	-	-	PUNCT
fnp-8974	480	5	mutant	mutant	NOUN
fnp-8974	480	6	and	and	CCONJ
fnp-8974	480	7	1p/19q	1p/19q	NOUN
fnp-8974	480	8	-	-	PUNCT
fnp-8974	480	9	codeleted	codelete	VERB
fnp-8974	480	10	oligodendrogliomas	oligodendroglioma	NOUN
fnp-8974	480	11	assigned	assign	VERB
fnp-8974	480	12	to	to	ADP
fnp-8974	480	13	the	the	DET
fnp-8974	480	14	astrocytoma	astrocytoma	NOUN
fnp-8974	480	15	,	,	PUNCT
fnp-8974	480	16	idh	idh	NOUN
fnp-8974	480	17	-	-	PUNCT
fnp-8974	480	18	mutant	mutant	NOUN
fnp-8974	480	19	high	high	ADJ
fnp-8974	480	20	grade	grade	NOUN
fnp-8974	480	21	methylation	methylation	NOUN
fnp-8974	480	22	class	class	NOUN
fnp-8974	480	23	exhibited	exhibit	VERB
fnp-8974	480	24	a	a	DET
fnp-8974	480	25	loss	loss	NOUN
fnp-8974	480	26	of	of	ADP
fnp-8974	480	27	global	global	ADJ
fnp-8974	480	28	dna	dna	PROPN
fnp-8974	480	29	hypermethylation	hypermethylation	NOUN
fnp-8974	480	30	and	and	CCONJ
fnp-8974	480	31	significantly	significantly	ADV
fnp-8974	480	32	worse	bad	ADJ
fnp-8974	480	33	overall	overall	ADJ
fnp-8974	480	34	survival	survival	NOUN
fnp-8974	480	35	compared	compare	VERB
fnp-8974	480	36	to	to	ADP
fnp-8974	480	37	cns	cns	PROPN
fnp-8974	480	38	who	who	PRON
fnp-8974	480	39	grade	grade	VERB
fnp-8974	480	40	3	3	NUM
fnp-8974	480	41	idh	idh	NOUN
fnp-8974	480	42	-	-	PUNCT
fnp-8974	480	43	mutant	mutant	NOUN
fnp-8974	480	44	and	and	CCONJ
fnp-8974	480	45	1p/19q	1p/19q	NOUN
fnp-8974	480	46	-	-	PUNCT
fnp-8974	480	47	codeleted	codelete	VERB
fnp-8974	480	48	oligodendrogliomas	oligodendroglioma	NOUN
fnp-8974	480	49	assigned	assign	VERB
fnp-8974	480	50	to	to	ADP
fnp-8974	480	51	the	the	DET
fnp-8974	480	52	oligodendroglioma	oligodendroglioma	ADJ
fnp-8974	480	53	methylation	methylation	NOUN
fnp-8974	480	54	class	class	NOUN
fnp-8974	480	55	(	(	PUNCT
fnp-8974	480	56	p	p	X
fnp-8974	480	57	 	 	SPACE
fnp-8974	480	58	=	=	NOUN
fnp-8974	480	59	 	 	SPACE
fnp-8974	480	60	0.0019	0.0019	NUM
fnp-8974	480	61	)	)	PUNCT
fnp-8974	480	62	.	.	PUNCT
fnp-8974	481	1	deconvolution	deconvolution	NOUN
fnp-8974	481	2	revealed	reveal	VERB
fnp-8974	481	3	a	a	DET
fnp-8974	481	4	higher	high	ADJ
fnp-8974	481	5	proportion	proportion	NOUN
fnp-8974	481	6	of	of	ADP
fnp-8974	481	7	residual	residual	ADJ
fnp-8974	481	8	brain	brain	NOUN
fnp-8974	481	9	tissue	tissue	NOUN
fnp-8974	481	10	in	in	ADP
fnp-8974	481	11	oligodendrogliomas	oligodendroglioma	NOUN
fnp-8974	481	12	classified	classify	VERB
fnp-8974	481	13	as	as	ADP
fnp-8974	481	14	idh	idh	NOUN
fnp-8974	481	15	-	-	PUNCT
fnp-8974	481	16	mutant	mutant	NOUN
fnp-8974	481	17	astrocytoma	astrocytoma	NOUN
fnp-8974	481	18	,	,	PUNCT
fnp-8974	481	19	lower	low	ADJ
fnp-8974	481	20	grade	grade	NOUN
fnp-8974	481	21	compared	compare	VERB
fnp-8974	481	22	to	to	ADP
fnp-8974	481	23	other	other	ADJ
fnp-8974	481	24	methylation	methylation	NOUN
fnp-8974	481	25	classes	class	NOUN
fnp-8974	481	26	of	of	ADP
fnp-8974	481	27	idh	idh	NOUN
fnp-8974	481	28	-	-	PUNCT
fnp-8974	481	29	mutant	mutant	NOUN
fnp-8974	481	30	gliomas	glioma	NOUN
fnp-8974	481	31	.	.	PUNCT
fnp-8974	482	1	conclusion(s	conclusion(s	NOUN
fnp-8974	482	2	):	):	PUNCT
fnp-8974	482	3	our	our	PRON
fnp-8974	482	4	findings	finding	NOUN
fnp-8974	482	5	suggest	suggest	VERB
fnp-8974	482	6	that	that	SCONJ
fnp-8974	482	7	decreased	decrease	VERB
fnp-8974	482	8	global	global	ADJ
fnp-8974	482	9	dna	dna	PROPN
fnp-8974	482	10	methylation	methylation	NOUN
fnp-8974	482	11	in	in	ADP
fnp-8974	482	12	idh	idh	NOUN
fnp-8974	482	13	-	-	PUNCT
fnp-8974	482	14	mutant	mutant	NOUN
fnp-8974	482	15	and	and	CCONJ
fnp-8974	482	16	1p/19q	1p/19q	NOUN
fnp-8974	482	17	-	-	PUNCT
fnp-8974	482	18	codeleted	codelete	VERB
fnp-8974	482	19	oligodendrogliomas	oligodendroglioma	NOUN
fnp-8974	482	20	,	,	PUNCT
fnp-8974	482	21	as	as	SCONJ
fnp-8974	482	22	indicated	indicate	VERB
fnp-8974	482	23	by	by	ADP
fnp-8974	482	24	methylation	methylation	NOUN
fnp-8974	482	25	classification	classification	NOUN
fnp-8974	482	26	into	into	ADP
fnp-8974	482	27	the	the	DET
fnp-8974	482	28	astrocytoma	astrocytoma	NOUN
fnp-8974	482	29	,	,	PUNCT
fnp-8974	482	30	idh	idh	NOUN
fnp-8974	482	31	-	-	PUNCT
fnp-8974	482	32	mutant	mutant	NOUN
fnp-8974	482	33	,	,	PUNCT
fnp-8974	482	34	high	high	ADJ
fnp-8974	482	35	grade	grade	NOUN
fnp-8974	482	36	methylation	methylation	NOUN
fnp-8974	482	37	class	class	NOUN
fnp-8974	482	38	,	,	PUNCT
fnp-8974	482	39	is	be	AUX
fnp-8974	482	40	associated	associate	VERB
fnp-8974	482	41	with	with	ADP
fnp-8974	482	42	poorer	poor	ADJ
fnp-8974	482	43	overall	overall	ADJ
fnp-8974	482	44	survival	survival	NOUN
fnp-8974	482	45	.	.	PUNCT
fnp-8974	483	1	p37	p37	VERB
fnp-8974	483	2	free	free	ADJ
fnp-8974	483	3	neuropathol	neuropathol	NOUN
fnp-8974	483	4	6:17:57	6:17:57	NUM
fnp-8974	483	5	leveraging	leverage	VERB
fnp-8974	483	6	peptide	peptide	NOUN
fnp-8974	483	7	-	-	PUNCT
fnp-8974	483	8	level	level	NOUN
fnp-8974	483	9	proteomics	proteomic	NOUN
fnp-8974	483	10	to	to	PART
fnp-8974	483	11	detect	detect	VERB
fnp-8974	483	12	brain	brain	NOUN
fnp-8974	483	13	cancer	cancer	NOUN
fnp-8974	483	14	specific	specific	ADJ
fnp-8974	483	15	proteoforms	proteoform	NOUN
fnp-8974	483	16	ian	ian	PROPN
fnp-8974	483	17	fichtner1,2	fichtner1,2	PROPN
fnp-8974	483	18	,	,	PUNCT
fnp-8974	483	19	fuat	fuat	PROPN
fnp-8974	483	20	kaan1,2	kaan1,2	PROPN
fnp-8974	483	21	,	,	PUNCT
fnp-8974	483	22	gianluca	gianluca	PROPN
fnp-8974	483	23	sigismondo1,2	sigismondo1,2	PROPN
fnp-8974	483	24	,	,	PUNCT
fnp-8974	483	25	christel	christel	PROPN
fnp-8974	483	26	herold	herold	PROPN
fnp-8974	483	27	-	-	PUNCT
fnp-8974	483	28	mende1	mende1	PROPN
fnp-8974	483	29	,	,	PUNCT
fnp-8974	483	30	sandro	sandro	PROPN
fnp-8974	483	31	krieg1	krieg1	PROPN
fnp-8974	483	32	,	,	PUNCT
fnp-8974	483	33	wolfgang	wolfgang	PROPN
fnp-8974	483	34	wick1	wick1	PROPN
fnp-8974	483	35	,	,	PUNCT
fnp-8974	483	36	andreas	andreas	PROPN
fnp-8974	483	37	von	von	PROPN
fnp-8974	483	38	deimling1,2	deimling1,2	PROPN
fnp-8974	483	39	,	,	PUNCT
fnp-8974	483	40	felix	felix	PROPN
fnp-8974	483	41	sahm1,2	sahm1,2	PROPN
fnp-8974	483	42	,	,	PUNCT
fnp-8974	483	43	moritz	moritz	PROPN
fnp-8974	483	44	gerstung2	gerstung2	PROPN
fnp-8974	483	45	,	,	PUNCT
fnp-8974	483	46	isabell	isabell	PROPN
fnp-8974	483	47	bludau1,2	bludau1,2	PROPN
fnp-8974	483	48	1	1	NUM
fnp-8974	483	49	heidelberg	heidelberg	NOUN
fnp-8974	483	50	university	university	NOUN
fnp-8974	483	51	hospital	hospital	NOUN
fnp-8974	483	52	,	,	PUNCT
fnp-8974	483	53	heidelberg	heidelberg	PROPN
fnp-8974	483	54	,	,	PUNCT
fnp-8974	483	55	germany	germany	PROPN
fnp-8974	483	56	2	2	NUM
fnp-8974	483	57	german	german	ADJ
fnp-8974	483	58	cancer	cancer	NOUN
fnp-8974	483	59	research	research	NOUN
fnp-8974	483	60	center	center	NOUN
fnp-8974	483	61	(	(	PUNCT
fnp-8974	483	62	dkfz	dkfz	PROPN
fnp-8974	483	63	)	)	PUNCT
fnp-8974	483	64	,	,	PUNCT
fnp-8974	483	65	heidelberg	heidelberg	PROPN
fnp-8974	483	66	,	,	PUNCT
fnp-8974	483	67	germany	germany	PROPN
fnp-8974	483	68	background	background	NOUN
fnp-8974	483	69	:	:	PUNCT
fnp-8974	483	70	conventional	conventional	ADJ
fnp-8974	483	71	bottom	bottom	ADJ
fnp-8974	483	72	-	-	PUNCT
fnp-8974	483	73	up	up	ADP
fnp-8974	483	74	proteomics	proteomic	NOUN
fnp-8974	483	75	approaches	approach	NOUN
fnp-8974	483	76	rely	rely	VERB
fnp-8974	483	77	on	on	ADP
fnp-8974	483	78	protein	protein	NOUN
fnp-8974	483	79	-	-	PUNCT
fnp-8974	483	80	group	group	NOUN
fnp-8974	483	81	inference	inference	NOUN
fnp-8974	483	82	.	.	PUNCT
fnp-8974	484	1	this	this	DET
fnp-8974	484	2	strategy	strategy	NOUN
fnp-8974	484	3	overlooks	overlook	VERB
fnp-8974	484	4	peptide	peptide	ADJ
fnp-8974	484	5	-	-	PUNCT
fnp-8974	484	6	level	level	NOUN
fnp-8974	484	7	information	information	NOUN
fnp-8974	484	8	of	of	ADP
fnp-8974	484	9	the	the	DET
fnp-8974	484	10	proteome	proteome	NOUN
fnp-8974	484	11	—	—	PUNCT
fnp-8974	484	12	particularly	particularly	ADV
fnp-8974	484	13	the	the	DET
fnp-8974	484	14	existence	existence	NOUN
fnp-8974	484	15	of	of	ADP
fnp-8974	484	16	proteoforms	proteoform	NOUN
fnp-8974	484	17	,	,	PUNCT
fnp-8974	484	18	which	which	PRON
fnp-8974	484	19	are	be	AUX
fnp-8974	484	20	distinct	distinct	ADJ
fnp-8974	484	21	molecular	molecular	ADJ
fnp-8974	484	22	species	specie	NOUN
fnp-8974	484	23	originating	originate	VERB
fnp-8974	484	24	from	from	ADP
fnp-8974	484	25	a	a	DET
fnp-8974	484	26	single	single	ADJ
fnp-8974	484	27	gene	gene	NOUN
fnp-8974	484	28	locus	locus	NOUN
fnp-8974	484	29	via	via	ADP
fnp-8974	484	30	mechanisms	mechanism	NOUN
fnp-8974	484	31	such	such	ADJ
fnp-8974	484	32	as	as	ADP
fnp-8974	484	33	alternative	alternative	ADJ
fnp-8974	484	34	splicing	splicing	NOUN
fnp-8974	484	35	,	,	PUNCT
fnp-8974	484	36	proteolytic	proteolytic	ADJ
fnp-8974	484	37	cleavage	cleavage	NOUN
fnp-8974	484	38	,	,	PUNCT
fnp-8974	484	39	and	and	CCONJ
fnp-8974	484	40	post	post	ADJ
fnp-8974	484	41	-	-	ADJ
fnp-8974	484	42	translational	translational	ADJ
fnp-8974	484	43	modifications	modification	NOUN
fnp-8974	484	44	.	.	PUNCT
fnp-8974	485	1	the	the	DET
fnp-8974	485	2	commonly	commonly	ADV
fnp-8974	485	3	overlooked	overlook	VERB
fnp-8974	485	4	proteoform	proteoform	NOUN
fnp-8974	485	5	level	level	NOUN
fnp-8974	485	6	is	be	AUX
fnp-8974	485	7	expected	expect	VERB
fnp-8974	485	8	to	to	PART
fnp-8974	485	9	provide	provide	VERB
fnp-8974	485	10	clinically	clinically	ADV
fnp-8974	485	11	valuable	valuable	ADJ
fnp-8974	485	12	information	information	NOUN
fnp-8974	485	13	,	,	PUNCT
fnp-8974	485	14	especially	especially	ADV
fnp-8974	485	15	in	in	ADP
fnp-8974	485	16	the	the	DET
fnp-8974	485	17	context	context	NOUN
fnp-8974	485	18	of	of	ADP
fnp-8974	485	19	complex	complex	ADJ
fnp-8974	485	20	and	and	CCONJ
fnp-8974	485	21	molecularly	molecularly	ADV
fnp-8974	485	22	heterogeneous	heterogeneous	ADJ
fnp-8974	485	23	diseases	disease	NOUN
fnp-8974	485	24	such	such	ADJ
fnp-8974	485	25	as	as	ADP
fnp-8974	485	26	brain	brain	NOUN
fnp-8974	485	27	cancers	cancer	NOUN
fnp-8974	485	28	.	.	PUNCT
fnp-8974	486	1	objective(s	objective(s	NOUN
fnp-8974	486	2	):	):	PUNCT
fnp-8974	486	3	this	this	DET
fnp-8974	486	4	study	study	NOUN
fnp-8974	486	5	leverages	leverage	VERB
fnp-8974	486	6	peptide	peptide	NOUN
fnp-8974	486	7	-	-	PUNCT
fnp-8974	486	8	level	level	NOUN
fnp-8974	486	9	data	datum	NOUN
fnp-8974	486	10	to	to	PART
fnp-8974	486	11	identify	identify	VERB
fnp-8974	486	12	and	and	CCONJ
fnp-8974	486	13	characterize	characterize	VERB
fnp-8974	486	14	differentially	differentially	ADV
fnp-8974	486	15	regulated	regulate	VERB
fnp-8974	486	16	proteoform	proteoform	NOUN
fnp-8974	486	17	-	-	PUNCT
fnp-8974	486	18	groups	group	NOUN
fnp-8974	486	19	across	across	ADP
fnp-8974	486	20	brain	brain	NOUN
fnp-8974	486	21	cancer	cancer	NOUN
fnp-8974	486	22	subtypes	subtype	NOUN
fnp-8974	486	23	.	.	PUNCT
fnp-8974	487	1	question(s	question(s	PROPN
fnp-8974	487	2	):	):	PUNCT
fnp-8974	487	3	do	do	AUX
fnp-8974	487	4	specific	specific	ADJ
fnp-8974	487	5	brain	brain	NOUN
fnp-8974	487	6	cancer	cancer	NOUN
fnp-8974	487	7	subtypes	subtype	NOUN
fnp-8974	487	8	exhibit	exhibit	VERB
fnp-8974	487	9	distinct	distinct	ADJ
fnp-8974	487	10	patterns	pattern	NOUN
fnp-8974	487	11	of	of	ADP
fnp-8974	487	12	proteoform	proteoform	NOUN
fnp-8974	487	13	-	-	PUNCT
fnp-8974	487	14	group	group	NOUN
fnp-8974	487	15	regulation	regulation	NOUN
fnp-8974	487	16	?	?	PUNCT
fnp-8974	488	1	if	if	SCONJ
fnp-8974	488	2	so	so	ADV
fnp-8974	488	3	,	,	PUNCT
fnp-8974	488	4	which	which	PRON
fnp-8974	488	5	subtypes	subtype	NOUN
fnp-8974	488	6	are	be	AUX
fnp-8974	488	7	affected	affect	VERB
fnp-8974	488	8	,	,	PUNCT
fnp-8974	488	9	how	how	SCONJ
fnp-8974	488	10	do	do	AUX
fnp-8974	488	11	these	these	DET
fnp-8974	488	12	patterns	pattern	NOUN
fnp-8974	488	13	differ	differ	VERB
fnp-8974	488	14	from	from	ADP
fnp-8974	488	15	those	those	PRON
fnp-8974	488	16	in	in	ADP
fnp-8974	488	17	other	other	ADJ
fnp-8974	488	18	tumor	tumor	NOUN
fnp-8974	488	19	classes	class	NOUN
fnp-8974	488	20	,	,	PUNCT
fnp-8974	488	21	and	and	CCONJ
fnp-8974	488	22	what	what	PRON
fnp-8974	488	23	molecular	molecular	ADJ
fnp-8974	488	24	mechanisms	mechanism	NOUN
fnp-8974	488	25	underlie	underlie	VERB
fnp-8974	488	26	these	these	DET
fnp-8974	488	27	regulatory	regulatory	ADJ
fnp-8974	488	28	differences	difference	NOUN
fnp-8974	488	29	?	?	PUNCT
fnp-8974	489	1	method(s	method(	VERB
fnp-8974	489	2	):	):	PUNCT
fnp-8974	489	3	to	to	PART
fnp-8974	489	4	address	address	VERB
fnp-8974	489	5	these	these	DET
fnp-8974	489	6	questions	question	NOUN
fnp-8974	489	7	,	,	PUNCT
fnp-8974	489	8	we	we	PRON
fnp-8974	489	9	applied	apply	VERB
fnp-8974	489	10	the	the	DET
fnp-8974	489	11	copf	copf	ADJ
fnp-8974	489	12	algorithm	algorithm	NOUN
fnp-8974	489	13	(	(	PUNCT
fnp-8974	489	14	bludau	bludau	NOUN
fnp-8974	489	15	et	et	PROPN
fnp-8974	489	16	al	al	PROPN
fnp-8974	489	17	.	.	PROPN
fnp-8974	489	18	,	,	PUNCT
fnp-8974	489	19	2021	2021	NUM
fnp-8974	489	20	)	)	PUNCT
fnp-8974	489	21	,	,	PUNCT
fnp-8974	489	22	which	which	PRON
fnp-8974	489	23	infers	infer	VERB
fnp-8974	489	24	proteoform	proteoform	NOUN
fnp-8974	489	25	-	-	PUNCT
fnp-8974	489	26	groups	group	NOUN
fnp-8974	489	27	based	base	VERB
fnp-8974	489	28	on	on	ADP
fnp-8974	489	29	peptide	peptide	ADJ
fnp-8974	489	30	correlation	correlation	NOUN
fnp-8974	489	31	patterns	pattern	NOUN
fnp-8974	489	32	,	,	PUNCT
fnp-8974	489	33	to	to	ADP
fnp-8974	489	34	a	a	DET
fnp-8974	489	35	clinical	clinical	ADJ
fnp-8974	489	36	mass	mass	ADJ
fnp-8974	489	37	-	-	PUNCT
fnp-8974	489	38	spectrometry	spectrometry	NOUN
fnp-8974	489	39	-	-	PUNCT
fnp-8974	489	40	based	base	VERB
fnp-8974	489	41	proteomics	proteomic	NOUN
fnp-8974	489	42	dataset	dataset	NOUN
fnp-8974	489	43	comprising	comprise	VERB
fnp-8974	489	44	31	31	NUM
fnp-8974	489	45	patient	patient	NOUN
fnp-8974	489	46	samples	sample	NOUN
fnp-8974	489	47	across	across	ADP
fnp-8974	489	48	4	4	NUM
fnp-8974	489	49	brain	brain	NOUN
fnp-8974	489	50	tumor	tumor	NOUN
fnp-8974	489	51	subtypes	subtype	NOUN
fnp-8974	489	52	,	,	PUNCT
fnp-8974	489	53	including	include	VERB
fnp-8974	489	54	astrocytoma	astrocytoma	NOUN
fnp-8974	489	55	,	,	PUNCT
fnp-8974	489	56	glioblastoma	glioblastoma	NOUN
fnp-8974	489	57	,	,	PUNCT
fnp-8974	489	58	meningioma	meningioma	NOUN
fnp-8974	489	59	and	and	CCONJ
fnp-8974	489	60	oligodendroglioma	oligodendroglioma	NOUN
fnp-8974	489	61	.	.	PUNCT
fnp-8974	490	1	result(s	result(s	PROPN
fnp-8974	490	2	):	):	PUNCT
fnp-8974	490	3	our	our	PRON
fnp-8974	490	4	analysis	analysis	NOUN
fnp-8974	490	5	revealed	reveal	VERB
fnp-8974	490	6	multiple	multiple	ADJ
fnp-8974	490	7	proteins	protein	NOUN
fnp-8974	490	8	with	with	ADP
fnp-8974	490	9	differentially	differentially	ADV
fnp-8974	490	10	regulated	regulate	VERB
fnp-8974	490	11	proteoform	proteoform	NOUN
fnp-8974	490	12	groups	group	NOUN
fnp-8974	490	13	across	across	ADP
fnp-8974	490	14	brain	brain	NOUN
fnp-8974	490	15	cancer	cancer	NOUN
fnp-8974	490	16	types	type	NOUN
fnp-8974	490	17	.	.	PUNCT
fnp-8974	491	1	notably	notably	ADV
fnp-8974	491	2	,	,	PUNCT
fnp-8974	491	3	rtn4	rtn4	PROPN
fnp-8974	491	4	(	(	PUNCT
fnp-8974	491	5	nogo	nogo	PROPN
fnp-8974	491	6	)	)	PUNCT
fnp-8974	491	7	and	and	CCONJ
fnp-8974	491	8	lima1	lima1	NOUN
fnp-8974	491	9	showed	show	VERB
fnp-8974	491	10	differential	differential	ADJ
fnp-8974	491	11	proteoform	proteoform	NOUN
fnp-8974	491	12	patterns	pattern	NOUN
fnp-8974	491	13	in	in	ADP
fnp-8974	491	14	meningioma	meningioma	NOUN
fnp-8974	491	15	compared	compare	VERB
fnp-8974	491	16	to	to	ADP
fnp-8974	491	17	other	other	ADJ
fnp-8974	491	18	subtypes	subtype	NOUN
fnp-8974	491	19	,	,	PUNCT
fnp-8974	491	20	matching	match	VERB
fnp-8974	491	21	known	know	VERB
fnp-8974	491	22	rna	rna	NOUN
fnp-8974	491	23	splice	splice	NOUN
fnp-8974	491	24	isoforms	isoform	NOUN
fnp-8974	491	25	,	,	PUNCT
fnp-8974	491	26	that	that	PRON
fnp-8974	491	27	would	would	AUX
fnp-8974	491	28	have	have	AUX
fnp-8974	491	29	been	be	AUX
fnp-8974	491	30	missed	miss	VERB
fnp-8974	491	31	in	in	ADP
fnp-8974	491	32	conventional	conventional	ADJ
fnp-8974	491	33	proteomics	proteomic	NOUN
fnp-8974	491	34	data	datum	NOUN
fnp-8974	491	35	analysis	analysis	NOUN
fnp-8974	491	36	.	.	PUNCT
fnp-8974	492	1	conclusion(s	conclusion(s	NOUN
fnp-8974	492	2	):	):	PUNCT
fnp-8974	492	3	proteoform	proteoform	NOUN
fnp-8974	492	4	-	-	PUNCT
fnp-8974	492	5	group	group	NOUN
fnp-8974	492	6	inference	inference	NOUN
fnp-8974	492	7	can	can	AUX
fnp-8974	492	8	reveal	reveal	VERB
fnp-8974	492	9	subtype	subtype	NOUN
fnp-8974	492	10	-	-	PUNCT
fnp-8974	492	11	specific	specific	ADJ
fnp-8974	492	12	expression	expression	NOUN
fnp-8974	492	13	patterns	pattern	NOUN
fnp-8974	492	14	,	,	PUNCT
fnp-8974	492	15	highlighting	highlight	VERB
fnp-8974	492	16	its	its	PRON
fnp-8974	492	17	utility	utility	NOUN
fnp-8974	492	18	for	for	ADP
fnp-8974	492	19	uncovering	uncover	VERB
fnp-8974	492	20	molecular	molecular	ADJ
fnp-8974	492	21	diversity	diversity	NOUN
fnp-8974	492	22	in	in	ADP
fnp-8974	492	23	brain	brain	NOUN
fnp-8974	492	24	cancer	cancer	NOUN
fnp-8974	492	25	and	and	CCONJ
fnp-8974	492	26	the	the	DET
fnp-8974	492	27	identification	identification	NOUN
fnp-8974	492	28	of	of	ADP
fnp-8974	492	29	novel	novel	ADJ
fnp-8974	492	30	biomarkers	biomarker	NOUN
fnp-8974	492	31	.	.	PUNCT
fnp-8974	493	1	p38	p38	NOUN
fnp-8974	493	2	free	free	ADJ
fnp-8974	493	3	neuropathol	neuropathol	NOUN
fnp-8974	493	4	6:17:58	6:17:58	NUM
fnp-8974	493	5	glioblastoma	glioblastoma	NOUN
fnp-8974	493	6	-	-	PUNCT
fnp-8974	493	7	derived	derive	VERB
fnp-8974	493	8	secreted	secrete	VERB
fnp-8974	493	9	proteins	protein	NOUN
fnp-8974	493	10	drive	drive	NOUN
fnp-8974	493	11	invasion	invasion	NOUN
fnp-8974	494	1	and	and	CCONJ
fnp-8974	494	2	affect	affect	VERB
fnp-8974	494	3	neuronal	neuronal	ADJ
fnp-8974	494	4	integrity	integrity	NOUN
fnp-8974	494	5	tanja	tanja	PROPN
fnp-8974	494	6	buhlmann1,2	buhlmann1,2	PROPN
fnp-8974	494	7	,	,	PUNCT
fnp-8974	494	8	youcef	youcef	PROPN
fnp-8974	494	9	dahmani1,2	dahmani1,2	PROPN
fnp-8974	494	10	,	,	PUNCT
fnp-8974	494	11	victor	victor	PROPN
fnp-8974	494	12	adrian	adrian	PROPN
fnp-8974	494	13	perez1,2	perez1,2	PROPN
fnp-8974	494	14	,	,	PUNCT
fnp-8974	494	15	karl	karl	PROPN
fnp-8974	494	16	heinz	heinz	PROPN
fnp-8974	494	17	plate2,3,4,5	plate2,3,4,5	NOUN
fnp-8974	494	18	,	,	PUNCT
fnp-8974	494	19	joachim	joachim	PROPN
fnp-8974	494	20	p.	p.	NOUN
fnp-8974	494	21	steinbach1,3,4,5	steinbach1,3,4,5	NOUN
fnp-8974	494	22	,	,	PUNCT
fnp-8974	494	23	ann	ann	PROPN
fnp-8974	494	24	-	-	PUNCT
fnp-8974	494	25	christin	christin	PROPN
fnp-8974	494	26	hau1,2,3,5,6	hau1,2,3,5,6	NOUN
fnp-8974	494	27	1	1	NUM
fnp-8974	494	28	dr	dr	PROPN
fnp-8974	494	29	.	.	PROPN
fnp-8974	494	30	senckenberg	senckenberg	PROPN
fnp-8974	494	31	institute	institute	PROPN
fnp-8974	494	32	of	of	ADP
fnp-8974	494	33	neurooncology	neurooncology	PROPN
fnp-8974	494	34	,	,	PUNCT
fnp-8974	494	35	university	university	NOUN
fnp-8974	494	36	hospital	hospital	NOUN
fnp-8974	494	37	frankfurt	frankfurt	PROPN
fnp-8974	494	38	,	,	PUNCT
fnp-8974	494	39	frankfurt	frankfurt	PROPN
fnp-8974	494	40	am	be	AUX
fnp-8974	494	41	main	main	ADJ
fnp-8974	494	42	,	,	PUNCT
fnp-8974	494	43	germany	germany	PROPN
fnp-8974	494	44	2	2	NUM
fnp-8974	494	45	institute	institute	PROPN
fnp-8974	494	46	of	of	ADP
fnp-8974	494	47	neurology	neurology	NOUN
fnp-8974	494	48	(	(	PUNCT
fnp-8974	494	49	edinger	edinger	PROPN
fnp-8974	494	50	institute	institute	PROPN
fnp-8974	494	51	)	)	PUNCT
fnp-8974	494	52	,	,	PUNCT
fnp-8974	494	53	university	university	NOUN
fnp-8974	494	54	hospital	hospital	NOUN
fnp-8974	494	55	frankfurt	frankfurt	PROPN
fnp-8974	494	56	,	,	PUNCT
fnp-8974	494	57	frankfurt	frankfurt	PROPN
fnp-8974	494	58	am	be	AUX
fnp-8974	494	59	main	main	ADJ
fnp-8974	494	60	,	,	PUNCT
fnp-8974	494	61	germany	germany	PROPN
fnp-8974	494	62	3	3	NUM
fnp-8974	494	63	frankfurt	frankfurt	PROPN
fnp-8974	494	64	cancer	cancer	PROPN
fnp-8974	494	65	institute	institute	PROPN
fnp-8974	494	66	(	(	PUNCT
fnp-8974	494	67	fci	fci	PROPN
fnp-8974	494	68	)	)	PUNCT
fnp-8974	495	1	,	,	PUNCT
fnp-8974	495	2	frankfurt	frankfurt	PROPN
fnp-8974	495	3	am	be	AUX
fnp-8974	495	4	main	main	ADJ
fnp-8974	495	5	,	,	PUNCT
fnp-8974	495	6	germany	germany	NOUN
fnp-8974	495	7	4	4	NUM
fnp-8974	495	8	german	german	ADJ
fnp-8974	495	9	cancer	cancer	NOUN
fnp-8974	495	10	consortium	consortium	NOUN
fnp-8974	495	11	(	(	PUNCT
fnp-8974	495	12	dktk	dktk	NOUN
fnp-8974	495	13	)	)	PUNCT
fnp-8974	495	14	,	,	PUNCT
fnp-8974	495	15	partner	partner	NOUN
fnp-8974	495	16	site	site	NOUN
fnp-8974	495	17	frankfurt	frankfurt	PROPN
fnp-8974	495	18	am	be	AUX
fnp-8974	495	19	mainz	mainz	NUM
fnp-8974	495	20	,	,	PUNCT
fnp-8974	495	21	frankfurt	frankfurt	PROPN
fnp-8974	495	22	am	be	AUX
fnp-8974	495	23	main	main	ADJ
fnp-8974	495	24	,	,	PUNCT
fnp-8974	495	25	germany	germany	PROPN
fnp-8974	495	26	5	5	NUM
fnp-8974	495	27	university	university	NOUN
fnp-8974	495	28	cancer	cancer	NOUN
fnp-8974	495	29	centre	centre	PROPN
fnp-8974	495	30	frankfurt	frankfurt	PROPN
fnp-8974	495	31	(	(	PUNCT
fnp-8974	495	32	uct	uct	PROPN
fnp-8974	495	33	)	)	PUNCT
fnp-8974	495	34	,	,	PUNCT
fnp-8974	495	35	university	university	NOUN
fnp-8974	495	36	hospital	hospital	NOUN
fnp-8974	495	37	frankfurt	frankfurt	PROPN
fnp-8974	495	38	,	,	PUNCT
fnp-8974	495	39	frankfurt	frankfurt	PROPN
fnp-8974	495	40	am	be	AUX
fnp-8974	495	41	main	main	ADJ
fnp-8974	495	42	,	,	PUNCT
fnp-8974	495	43	germany	germany	PROPN
fnp-8974	495	44	6	6	NUM
fnp-8974	495	45	mildred	mildred	PROPN
fnp-8974	495	46	scheel	scheel	PROPN
fnp-8974	495	47	nachwuchszentrum	nachwuchszentrum	PROPN
fnp-8974	495	48	(	(	PUNCT
fnp-8974	495	49	msnz	msnz	PROPN
fnp-8974	495	50	)	)	PUNCT
fnp-8974	495	51	,	,	PUNCT
fnp-8974	495	52	frankfurt	frankfurt	PROPN
fnp-8974	495	53	am	be	AUX
fnp-8974	495	54	main	main	ADJ
fnp-8974	495	55	,	,	PUNCT
fnp-8974	495	56	germany	germany	PROPN
fnp-8974	495	57	background	background	NOUN
fnp-8974	495	58	:	:	PUNCT
fnp-8974	495	59	glioblastoma	glioblastoma	NOUN
fnp-8974	495	60	(	(	PUNCT
fnp-8974	495	61	gb	gb	NOUN
fnp-8974	495	62	)	)	PUNCT
fnp-8974	495	63	is	be	AUX
fnp-8974	495	64	an	an	DET
fnp-8974	495	65	aggressive	aggressive	ADJ
fnp-8974	495	66	brain	brain	NOUN
fnp-8974	495	67	tumor	tumor	NOUN
fnp-8974	495	68	characterized	characterize	VERB
fnp-8974	495	69	by	by	ADP
fnp-8974	495	70	diffuse	diffuse	NOUN
fnp-8974	495	71	infiltration	infiltration	NOUN
fnp-8974	495	72	and	and	CCONJ
fnp-8974	495	73	reciprocal	reciprocal	ADJ
fnp-8974	495	74	interactions	interaction	NOUN
fnp-8974	495	75	with	with	ADP
fnp-8974	495	76	the	the	DET
fnp-8974	495	77	surrounding	surround	VERB
fnp-8974	495	78	brain	brain	NOUN
fnp-8974	495	79	tissue	tissue	NOUN
fnp-8974	495	80	,	,	PUNCT
fnp-8974	495	81	including	include	VERB
fnp-8974	495	82	neurons	neuron	NOUN
fnp-8974	495	83	.	.	PUNCT
fnp-8974	496	1	understanding	understand	VERB
fnp-8974	496	2	how	how	SCONJ
fnp-8974	496	3	tumor	tumor	NOUN
fnp-8974	496	4	-	-	PUNCT
fnp-8974	496	5	derived	derive	VERB
fnp-8974	496	6	factors	factor	NOUN
fnp-8974	496	7	contribute	contribute	VERB
fnp-8974	496	8	to	to	ADP
fnp-8974	496	9	both	both	DET
fnp-8974	496	10	invasion	invasion	NOUN
fnp-8974	496	11	and	and	CCONJ
fnp-8974	496	12	neuronal	neuronal	ADJ
fnp-8974	496	13	disruption	disruption	NOUN
fnp-8974	496	14	is	be	AUX
fnp-8974	496	15	critical	critical	ADJ
fnp-8974	496	16	to	to	ADP
fnp-8974	496	17	elucidating	elucidate	VERB
fnp-8974	496	18	glioma	glioma	NOUN
fnp-8974	496	19	-	-	PUNCT
fnp-8974	496	20	brain	brain	NOUN
fnp-8974	496	21	interactions	interaction	NOUN
fnp-8974	496	22	.	.	PUNCT
fnp-8974	497	1	objective	objective	NOUN
fnp-8974	497	2	:	:	PUNCT
fnp-8974	497	3	to	to	PART
fnp-8974	497	4	identify	identify	VERB
fnp-8974	497	5	glioma	glioma	NOUN
fnp-8974	497	6	-	-	PUNCT
fnp-8974	497	7	derived	derive	VERB
fnp-8974	497	8	secreted	secrete	VERB
fnp-8974	497	9	proteins	protein	NOUN
fnp-8974	497	10	that	that	PRON
fnp-8974	497	11	promote	promote	VERB
fnp-8974	497	12	tumor	tumor	NOUN
fnp-8974	497	13	cell	cell	NOUN
fnp-8974	497	14	invasion	invasion	NOUN
fnp-8974	497	15	and	and	CCONJ
fnp-8974	497	16	to	to	PART
fnp-8974	497	17	investigate	investigate	VERB
fnp-8974	497	18	whether	whether	SCONJ
fnp-8974	497	19	these	these	DET
fnp-8974	497	20	factors	factor	NOUN
fnp-8974	497	21	also	also	ADV
fnp-8974	497	22	affect	affect	VERB
fnp-8974	497	23	the	the	DET
fnp-8974	497	24	structural	structural	ADJ
fnp-8974	497	25	and	and	CCONJ
fnp-8974	497	26	functional	functional	ADJ
fnp-8974	497	27	integrity	integrity	NOUN
fnp-8974	497	28	of	of	ADP
fnp-8974	497	29	human	human	ADJ
fnp-8974	497	30	neurons	neuron	NOUN
fnp-8974	497	31	.	.	PUNCT
fnp-8974	498	1	methods	method	NOUN
fnp-8974	498	2	:	:	PUNCT
fnp-8974	498	3	we	we	PRON
fnp-8974	498	4	combined	combine	VERB
fnp-8974	498	5	two	two	NUM
fnp-8974	498	6	complementary	complementary	ADJ
fnp-8974	498	7	screening	screening	NOUN
fnp-8974	498	8	approaches	approach	NOUN
fnp-8974	498	9	in	in	ADP
fnp-8974	498	10	patient	patient	NOUN
fnp-8974	498	11	-	-	PUNCT
fnp-8974	498	12	derived	derive	VERB
fnp-8974	498	13	glioma	glioma	NOUN
fnp-8974	498	14	stem	stem	NOUN
fnp-8974	498	15	-	-	PUNCT
fnp-8974	498	16	like	like	ADJ
fnp-8974	498	17	cells	cell	NOUN
fnp-8974	498	18	(	(	PUNCT
fnp-8974	498	19	gscs	gsc	NOUN
fnp-8974	498	20	):	):	PUNCT
fnp-8974	498	21	(	(	PUNCT
fnp-8974	498	22	1	1	X
fnp-8974	498	23	)	)	PUNCT
fnp-8974	498	24	serial	serial	ADJ
fnp-8974	498	25	selection	selection	NOUN
fnp-8974	498	26	of	of	ADP
fnp-8974	498	27	highly	highly	ADV
fnp-8974	498	28	invasive	invasive	ADJ
fnp-8974	498	29	subpopulations	subpopulation	NOUN
fnp-8974	498	30	,	,	PUNCT
fnp-8974	498	31	and	and	CCONJ
fnp-8974	498	32	(	(	PUNCT
fnp-8974	498	33	2	2	X
fnp-8974	498	34	)	)	PUNCT
fnp-8974	498	35	a	a	DET
fnp-8974	498	36	genome	genome	NOUN
fnp-8974	498	37	-	-	PUNCT
fnp-8974	498	38	wide	wide	ADJ
fnp-8974	498	39	crispr	crispr	ADJ
fnp-8974	498	40	activation	activation	NOUN
fnp-8974	498	41	(	(	PUNCT
fnp-8974	498	42	crispra	crispra	ADJ
fnp-8974	498	43	)	)	PUNCT
fnp-8974	498	44	screen	screen	NOUN
fnp-8974	498	45	.	.	PUNCT
fnp-8974	499	1	candidate	candidate	NOUN
fnp-8974	499	2	factors	factor	NOUN
fnp-8974	499	3	were	be	AUX
fnp-8974	499	4	validated	validate	VERB
fnp-8974	499	5	via	via	ADP
fnp-8974	499	6	overexpression	overexpression	NOUN
fnp-8974	499	7	and	and	CCONJ
fnp-8974	499	8	crispr	crispr	ADJ
fnp-8974	499	9	/	/	SYM
fnp-8974	499	10	cas9	cas9	NOUN
fnp-8974	499	11	-	-	PUNCT
fnp-8974	499	12	mediated	mediate	VERB
fnp-8974	499	13	knockout	knockout	NOUN
fnp-8974	499	14	across	across	ADP
fnp-8974	499	15	multiple	multiple	ADJ
fnp-8974	499	16	gsc	gsc	PROPN
fnp-8974	499	17	lines	line	NOUN
fnp-8974	499	18	.	.	PUNCT
fnp-8974	500	1	functional	functional	ADJ
fnp-8974	500	2	consequences	consequence	NOUN
fnp-8974	500	3	were	be	AUX
fnp-8974	500	4	assessed	assess	VERB
fnp-8974	500	5	using	use	VERB
fnp-8974	500	6	2d	2d	NUM
fnp-8974	500	7	assays	assay	NOUN
fnp-8974	500	8	and	and	CCONJ
fnp-8974	500	9	3d	3d	NUM
fnp-8974	500	10	cerebral	cerebral	ADJ
fnp-8974	500	11	organoids	organoid	NOUN
fnp-8974	500	12	derived	derive	VERB
fnp-8974	500	13	from	from	ADP
fnp-8974	500	14	human	human	ADJ
fnp-8974	500	15	induced	induce	VERB
fnp-8974	500	16	pluripotent	pluripotent	ADJ
fnp-8974	500	17	stem	stem	NOUN
fnp-8974	500	18	cells	cell	NOUN
fnp-8974	500	19	(	(	PUNCT
fnp-8974	500	20	hipscs	hipsc	NOUN
fnp-8974	500	21	)	)	PUNCT
fnp-8974	500	22	,	,	PUNCT
fnp-8974	500	23	including	include	VERB
fnp-8974	500	24	live	live	ADJ
fnp-8974	500	25	-	-	PUNCT
fnp-8974	500	26	cell	cell	NOUN
fnp-8974	500	27	imaging	imaging	NOUN
fnp-8974	500	28	in	in	ADP
fnp-8974	500	29	the	the	DET
fnp-8974	500	30	glioma	glioma	NOUN
fnp-8974	500	31	cerebral	cerebral	ADJ
fnp-8974	500	32	organoid	organoid	NOUN
fnp-8974	500	33	(	(	PUNCT
fnp-8974	500	34	glico	glico	NOUN
fnp-8974	500	35	)	)	PUNCT
fnp-8974	500	36	model	model	NOUN
fnp-8974	500	37	.	.	PUNCT
fnp-8974	501	1	tumor	tumor	NOUN
fnp-8974	501	2	-	-	PUNCT
fnp-8974	501	3	neuron	neuron	NOUN
fnp-8974	501	4	interactions	interaction	NOUN
fnp-8974	501	5	were	be	AUX
fnp-8974	501	6	studied	study	VERB
fnp-8974	501	7	using	use	VERB
fnp-8974	501	8	a	a	DET
fnp-8974	501	9	competition	competition	NOUN
fnp-8974	501	10	assay	assay	VERB
fnp-8974	501	11	with	with	ADP
fnp-8974	501	12	fluorescently	fluorescently	ADV
fnp-8974	501	13	labelled	label	VERB
fnp-8974	501	14	wildtype	wildtype	NOUN
fnp-8974	501	15	and	and	CCONJ
fnp-8974	501	16	knockout	knockout	NOUN
fnp-8974	501	17	cells	cell	NOUN
fnp-8974	501	18	in	in	ADP
fnp-8974	501	19	co	co	NOUN
fnp-8974	501	20	-	-	NOUN
fnp-8974	501	21	culture	culture	NOUN
fnp-8974	501	22	with	with	ADP
fnp-8974	501	23	hipsc	hipsc	ADJ
fnp-8974	501	24	-	-	PUNCT
fnp-8974	501	25	derived	derive	VERB
fnp-8974	501	26	neurons	neuron	NOUN
fnp-8974	501	27	,	,	PUNCT
fnp-8974	501	28	and	and	CCONJ
fnp-8974	501	29	via	via	ADP
fnp-8974	501	30	direct	direct	ADJ
fnp-8974	501	31	exposure	exposure	NOUN
fnp-8974	501	32	of	of	ADP
fnp-8974	501	33	mature	mature	ADJ
fnp-8974	501	34	neurons	neuron	NOUN
fnp-8974	501	35	to	to	ADP
fnp-8974	501	36	recombinant	recombinant	ADJ
fnp-8974	501	37	proteins	protein	NOUN
fnp-8974	501	38	.	.	PUNCT
fnp-8974	502	1	results	result	NOUN
fnp-8974	502	2	:	:	PUNCT
fnp-8974	502	3	chi3l1	chi3l1	NOUN
fnp-8974	502	4	and	and	CCONJ
fnp-8974	502	5	igfbp5	igfbp5	NOUN
fnp-8974	502	6	were	be	AUX
fnp-8974	502	7	identified	identify	VERB
fnp-8974	502	8	as	as	ADP
fnp-8974	502	9	secreted	secrete	VERB
fnp-8974	502	10	regulators	regulator	NOUN
fnp-8974	502	11	of	of	ADP
fnp-8974	502	12	glioma	glioma	NOUN
fnp-8974	502	13	invasion	invasion	NOUN
fnp-8974	502	14	,	,	PUNCT
fnp-8974	502	15	enriched	enrich	VERB
fnp-8974	502	16	at	at	ADP
fnp-8974	502	17	the	the	DET
fnp-8974	502	18	tumor	tumor	NOUN
fnp-8974	502	19	invasive	invasive	ADJ
fnp-8974	502	20	front	front	NOUN
fnp-8974	502	21	.	.	PUNCT
fnp-8974	503	1	functional	functional	ADJ
fnp-8974	503	2	assays	assay	NOUN
fnp-8974	503	3	demonstrated	demonstrate	VERB
fnp-8974	503	4	consistent	consistent	ADJ
fnp-8974	503	5	effects	effect	NOUN
fnp-8974	503	6	on	on	ADP
fnp-8974	503	7	cell	cell	NOUN
fnp-8974	503	8	motility	motility	NOUN
fnp-8974	503	9	and	and	CCONJ
fnp-8974	503	10	infiltration	infiltration	NOUN
fnp-8974	503	11	.	.	PUNCT
fnp-8974	504	1	exposure	exposure	NOUN
fnp-8974	504	2	of	of	ADP
fnp-8974	504	3	neurons	neuron	NOUN
fnp-8974	504	4	to	to	PART
fnp-8974	504	5	recombinant	recombinant	VERB
fnp-8974	504	6	chi3l1	chi3l1	NOUN
fnp-8974	504	7	or	or	CCONJ
fnp-8974	504	8	igfbp5	igfbp5	NOUN
fnp-8974	504	9	led	lead	VERB
fnp-8974	504	10	to	to	ADP
fnp-8974	504	11	synaptic	synaptic	ADJ
fnp-8974	504	12	alterations	alteration	NOUN
fnp-8974	504	13	and	and	CCONJ
fnp-8974	504	14	neurotoxic	neurotoxic	ADJ
fnp-8974	504	15	effects	effect	NOUN
fnp-8974	504	16	.	.	PUNCT
fnp-8974	505	1	conclusion	conclusion	NOUN
fnp-8974	505	2	:	:	PUNCT
fnp-8974	505	3	chi3l1	chi3l1	NOUN
fnp-8974	505	4	and	and	CCONJ
fnp-8974	505	5	igfbp5	igfbp5	NOUN
fnp-8974	505	6	are	be	AUX
fnp-8974	505	7	secreted	secrete	VERB
fnp-8974	505	8	drivers	driver	NOUN
fnp-8974	505	9	of	of	ADP
fnp-8974	505	10	glioma	glioma	NOUN
fnp-8974	505	11	invasion	invasion	NOUN
fnp-8974	505	12	and	and	CCONJ
fnp-8974	505	13	modulators	modulator	NOUN
fnp-8974	505	14	of	of	ADP
fnp-8974	505	15	neuronal	neuronal	ADJ
fnp-8974	505	16	integrity	integrity	NOUN
fnp-8974	505	17	.	.	PUNCT
fnp-8974	506	1	these	these	DET
fnp-8974	506	2	findings	finding	NOUN
fnp-8974	506	3	underscore	underscore	VERB
fnp-8974	506	4	the	the	DET
fnp-8974	506	5	importance	importance	NOUN
fnp-8974	506	6	of	of	ADP
fnp-8974	506	7	tumor	tumor	NOUN
fnp-8974	506	8	-	-	PUNCT
fnp-8974	506	9	neuron	neuron	NOUN
fnp-8974	506	10	interactions	interaction	NOUN
fnp-8974	506	11	,	,	PUNCT
fnp-8974	506	12	particularly	particularly	ADV
fnp-8974	506	13	at	at	ADP
fnp-8974	506	14	the	the	DET
fnp-8974	506	15	invasive	invasive	ADJ
fnp-8974	506	16	front	front	NOUN
fnp-8974	506	17	where	where	SCONJ
fnp-8974	506	18	single	single	ADJ
fnp-8974	506	19	tumor	tumor	NOUN
fnp-8974	506	20	cells	cell	NOUN
fnp-8974	506	21	interface	interface	NOUN
fnp-8974	506	22	with	with	ADP
fnp-8974	506	23	intact	intact	ADJ
fnp-8974	506	24	brain	brain	NOUN
fnp-8974	506	25	parenchyma	parenchyma	NOUN
fnp-8974	506	26	.	.	PUNCT
fnp-8974	507	1	p39	p39	ADJ
fnp-8974	507	2	free	free	ADJ
fnp-8974	507	3	neuropathol	neuropathol	NOUN
fnp-8974	507	4	6:17:59	6:17:59	NUM
fnp-8974	507	5	establishment	establishment	NOUN
fnp-8974	507	6	of	of	ADP
fnp-8974	507	7	droplet	droplet	ADJ
fnp-8974	507	8	digital	digital	ADJ
fnp-8974	507	9	™	™	ADJ
fnp-8974	507	10	pcr	pcr	NOUN
fnp-8974	507	11	(	(	PUNCT
fnp-8974	507	12	ddpcr	ddpcr	NOUN
fnp-8974	507	13	™	™	VERB
fnp-8974	507	14	)-based	)-base	VERB
fnp-8974	507	15	assays	assay	NOUN
fnp-8974	507	16	for	for	ADP
fnp-8974	507	17	the	the	DET
fnp-8974	507	18	diagnostic	diagnostic	ADJ
fnp-8974	507	19	detection	detection	NOUN
fnp-8974	507	20	of	of	ADP
fnp-8974	507	21	mgmt	mgmt	PROPN
fnp-8974	507	22	promoter	promoter	NOUN
fnp-8974	507	23	methylation	methylation	NOUN
fnp-8974	507	24	in	in	ADP
fnp-8974	507	25	malignant	malignant	ADJ
fnp-8974	507	26	gliomas	glioma	NOUN
fnp-8974	507	27	marietta	marietta	PROPN
fnp-8974	507	28	wolter1	wolter1	PROPN
fnp-8974	507	29	,	,	PUNCT
fnp-8974	507	30	david	david	PROPN
fnp-8974	507	31	pauck1	pauck1	PROPN
fnp-8974	507	32	,	,	PUNCT
fnp-8974	507	33	jörg	jörg	PROPN
fnp-8974	507	34	felsberg1	felsberg1	PROPN
fnp-8974	507	35	,	,	PUNCT
fnp-8974	507	36	guido	guido	NOUN
fnp-8974	507	37	reifenberger1,2	reifenberger1,2	PROPN
fnp-8974	507	38	1	1	NUM
fnp-8974	507	39	university	university	NOUN
fnp-8974	507	40	hospital	hospital	NOUN
fnp-8974	507	41	düsseldorf	düsseldorf	PROPN
fnp-8974	507	42	,	,	PUNCT
fnp-8974	507	43	medical	medical	ADJ
fnp-8974	507	44	faculty	faculty	NOUN
fnp-8974	507	45	,	,	PUNCT
fnp-8974	507	46	heinrich	heinrich	PROPN
fnp-8974	507	47	-	-	PUNCT
fnp-8974	507	48	heine	heine	PROPN
fnp-8974	507	49	-	-	PUNCT
fnp-8974	507	50	university	university	PROPN
fnp-8974	507	51	düsseldorf	düsseldorf	PROPN
fnp-8974	507	52	,	,	PUNCT
fnp-8974	507	53	institute	institute	PROPN
fnp-8974	507	54	of	of	ADP
fnp-8974	507	55	neuropathology	neuropathology	PROPN
fnp-8974	507	56	,	,	PUNCT
fnp-8974	507	57	düsseldorf	düsseldorf	PROPN
fnp-8974	507	58	,	,	PUNCT
fnp-8974	507	59	germany	germany	PROPN
fnp-8974	507	60	2	2	NUM
fnp-8974	507	61	german	german	ADJ
fnp-8974	507	62	cancer	cancer	NOUN
fnp-8974	507	63	consortium	consortium	NOUN
fnp-8974	507	64	(	(	PUNCT
fnp-8974	507	65	dktk	dktk	NOUN
fnp-8974	507	66	)	)	PUNCT
fnp-8974	507	67	,	,	PUNCT
fnp-8974	507	68	german	german	ADJ
fnp-8974	507	69	cancer	cancer	NOUN
fnp-8974	507	70	research	research	NOUN
fnp-8974	507	71	center	center	NOUN
fnp-8974	507	72	(	(	PUNCT
fnp-8974	507	73	dkfz	dkfz	ADJ
fnp-8974	507	74	)	)	PUNCT
fnp-8974	507	75	heidelberg	heidelberg	NOUN
fnp-8974	507	76	,	,	PUNCT
fnp-8974	507	77	partner	partner	NOUN
fnp-8974	507	78	site	site	NOUN
fnp-8974	507	79	essen	essen	PROPN
fnp-8974	507	80	/	/	SYM
fnp-8974	507	81	düsseldorf	düsseldorf	PROPN
fnp-8974	507	82	,	,	PUNCT
fnp-8974	507	83	germany	germany	PROPN
fnp-8974	507	84	,	,	PUNCT
fnp-8974	507	85	essen	essen	PROPN
fnp-8974	507	86	/	/	SYM
fnp-8974	507	87	düsseldorf	düsseldorf	PROPN
fnp-8974	507	88	,	,	PUNCT
fnp-8974	507	89	germany	germany	PROPN
fnp-8974	507	90	mgmt	mgmt	PROPN
fnp-8974	507	91	promoter	promoter	PROPN
fnp-8974	507	92	methylation	methylation	NOUN
fnp-8974	507	93	is	be	AUX
fnp-8974	507	94	the	the	DET
fnp-8974	507	95	most	most	ADV
fnp-8974	507	96	relevant	relevant	ADJ
fnp-8974	507	97	predictor	predictor	NOUN
fnp-8974	507	98	of	of	ADP
fnp-8974	507	99	response	response	NOUN
fnp-8974	507	100	to	to	ADP
fnp-8974	507	101	chemotherapy	chemotherapy	NOUN
fnp-8974	507	102	with	with	ADP
fnp-8974	507	103	temozolomide	temozolomide	NOUN
fnp-8974	507	104	(	(	PUNCT
fnp-8974	507	105	tmz	tmz	NOUN
fnp-8974	507	106	)	)	PUNCT
fnp-8974	507	107	in	in	ADP
fnp-8974	507	108	patients	patient	NOUN
fnp-8974	507	109	with	with	ADP
fnp-8974	507	110	newly	newly	ADV
fnp-8974	507	111	diagnosed	diagnose	VERB
fnp-8974	507	112	idh	idh	NOUN
fnp-8974	507	113	-	-	PUNCT
fnp-8974	507	114	wildtype	wildtype	NOUN
fnp-8974	507	115	glioblastoma	glioblastoma	NOUN
fnp-8974	507	116	.	.	PUNCT
fnp-8974	508	1	in	in	ADP
fnp-8974	508	2	routine	routine	ADJ
fnp-8974	508	3	diagnostics	diagnostic	NOUN
fnp-8974	508	4	,	,	PUNCT
fnp-8974	508	5	the	the	DET
fnp-8974	508	6	mgmt	mgmt	PROPN
fnp-8974	508	7	promoter	promoter	NOUN
fnp-8974	508	8	methylation	methylation	NOUN
fnp-8974	508	9	status	status	NOUN
fnp-8974	508	10	is	be	AUX
fnp-8974	508	11	commonly	commonly	ADV
fnp-8974	508	12	assessed	assess	VERB
fnp-8974	508	13	by	by	ADP
fnp-8974	508	14	either	either	CCONJ
fnp-8974	508	15	pyrosequencing	pyrosequence	VERB
fnp-8974	508	16	(	(	PUNCT
fnp-8974	508	17	psq	psq	NOUN
fnp-8974	508	18	)	)	PUNCT
fnp-8974	508	19	of	of	ADP
fnp-8974	508	20	bisulfite	bisulfite	NOUN
fnp-8974	508	21	-	-	PUNCT
fnp-8974	508	22	modified	modify	VERB
fnp-8974	508	23	dna	dna	NOUN
fnp-8974	508	24	or	or	CCONJ
fnp-8974	508	25	global	global	ADJ
fnp-8974	508	26	epicv2	epicv2	PROPN
fnp-8974	508	27	bead	bead	PROPN
fnp-8974	508	28	array	array	NOUN
fnp-8974	508	29	-	-	PUNCT
fnp-8974	508	30	based	base	VERB
fnp-8974	508	31	dna	dna	PROPN
fnp-8974	508	32	methylation	methylation	NOUN
fnp-8974	508	33	profiling	profiling	NOUN
fnp-8974	508	34	using	use	VERB
fnp-8974	508	35	the	the	DET
fnp-8974	508	36	stp27	stp27	NOUN
fnp-8974	508	37	algorithm	algorithm	NOUN
fnp-8974	508	38	.	.	PUNCT
fnp-8974	509	1	we	we	PRON
fnp-8974	509	2	aimed	aim	VERB
fnp-8974	509	3	to	to	PART
fnp-8974	509	4	establish	establish	VERB
fnp-8974	509	5	and	and	CCONJ
fnp-8974	509	6	validate	validate	VERB
fnp-8974	509	7	ddpcr	ddpcr	NOUN
fnp-8974	509	8	™	™	NOUN
fnp-8974	509	9	as	as	ADP
fnp-8974	509	10	a	a	DET
fnp-8974	509	11	novel	novel	ADJ
fnp-8974	509	12	method	method	NOUN
fnp-8974	509	13	to	to	PART
fnp-8974	509	14	allow	allow	VERB
fnp-8974	509	15	for	for	ADP
fnp-8974	509	16	rapid	rapid	ADJ
fnp-8974	509	17	diagnostic	diagnostic	ADJ
fnp-8974	509	18	detection	detection	NOUN
fnp-8974	509	19	of	of	ADP
fnp-8974	509	20	the	the	DET
fnp-8974	509	21	methylation	methylation	NOUN
fnp-8974	509	22	status	status	NOUN
fnp-8974	509	23	at	at	ADP
fnp-8974	509	24	relevant	relevant	ADJ
fnp-8974	509	25	cpg	cpg	NOUN
fnp-8974	509	26	sites	site	NOUN
fnp-8974	509	27	in	in	ADP
fnp-8974	509	28	the	the	DET
fnp-8974	509	29	mgmt	mgmt	PROPN
fnp-8974	509	30	promoter	promoter	NOUN
fnp-8974	509	31	-	-	PUNCT
fnp-8974	509	32	associated	associate	VERB
fnp-8974	509	33	cpg98	cpg98	PROPN
fnp-8974	509	34	island	island	NOUN
fnp-8974	509	35	.	.	PUNCT
fnp-8974	510	1	results	result	NOUN
fnp-8974	510	2	obtained	obtain	VERB
fnp-8974	510	3	by	by	ADP
fnp-8974	510	4	ddpcr	ddpcr	ADJ
fnp-8974	510	5	™	™	NOUN
fnp-8974	510	6	were	be	AUX
fnp-8974	510	7	compared	compare	VERB
fnp-8974	510	8	to	to	ADP
fnp-8974	510	9	those	those	PRON
fnp-8974	510	10	obtained	obtain	VERB
fnp-8974	510	11	by	by	ADP
fnp-8974	510	12	psq	psq	NOUN
fnp-8974	510	13	or	or	CCONJ
fnp-8974	510	14	stp27	stp27	NOUN
fnp-8974	510	15	.	.	PUNCT
fnp-8974	511	1	in	in	ADP
fnp-8974	511	2	total	total	NOUN
fnp-8974	511	3	,	,	PUNCT
fnp-8974	511	4	we	we	PRON
fnp-8974	511	5	established	establish	VERB
fnp-8974	511	6	three	three	NUM
fnp-8974	511	7	different	different	ADJ
fnp-8974	511	8	duplex	duplex	NOUN
fnp-8974	511	9	-	-	PUNCT
fnp-8974	511	10	ddpcr	ddpcr	NOUN
fnp-8974	511	11	™	™	ADJ
fnp-8974	511	12	assays	assay	NOUN
fnp-8974	511	13	to	to	PART
fnp-8974	511	14	analyse	analyse	VERB
fnp-8974	511	15	the	the	DET
fnp-8974	511	16	methylation	methylation	NOUN
fnp-8974	511	17	status	status	NOUN
fnp-8974	511	18	at	at	ADP
fnp-8974	511	19	selected	select	VERB
fnp-8974	511	20	cpg	cpg	NOUN
fnp-8974	511	21	sites	site	NOUN
fnp-8974	511	22	covering	cover	VERB
fnp-8974	511	23	(	(	PUNCT
fnp-8974	511	24	1	1	NUM
fnp-8974	511	25	)	)	PUNCT
fnp-8974	511	26	four	four	NUM
fnp-8974	511	27	of	of	ADP
fnp-8974	511	28	the	the	DET
fnp-8974	511	29	cpg	cpg	NOUN
fnp-8974	511	30	sites	site	NOUN
fnp-8974	511	31	commonly	commonly	ADV
fnp-8974	511	32	analysed	analyse	VERB
fnp-8974	511	33	by	by	ADP
fnp-8974	511	34	psq	psq	NOUN
fnp-8974	511	35	(	(	PUNCT
fnp-8974	511	36	cpgs	cpgs	NOUN
fnp-8974	511	37	76–79	76–79	ADV
fnp-8974	511	38	,	,	PUNCT
fnp-8974	511	39	numbering	numbering	NOUN
fnp-8974	511	40	of	of	ADP
fnp-8974	511	41	cpg	cpg	NOUN
fnp-8974	511	42	sites	site	NOUN
fnp-8974	511	43	in	in	ADP
fnp-8974	511	44	the	the	DET
fnp-8974	511	45	mgmt	mgmt	NOUN
fnp-8974	511	46	-	-	PUNCT
fnp-8974	511	47	associated	associate	VERB
fnp-8974	511	48	cpg98	cpg98	PROPN
fnp-8974	511	49	island	island	NOUN
fnp-8974	511	50	according	accord	VERB
fnp-8974	511	51	to	to	ADP
fnp-8974	511	52	malley	malley	PROPN
fnp-8974	511	53	et	et	PROPN
fnp-8974	511	54	al	al	PROPN
fnp-8974	511	55	.	.	PROPN
fnp-8974	511	56	,	,	PUNCT
fnp-8974	511	57	acta	acta	PROPN
fnp-8974	511	58	neuropathol	neuropathol	PROPN
fnp-8974	511	59	.	.	PUNCT
fnp-8974	512	1	2011	2011	NUM
fnp-8974	512	2	,	,	PUNCT
fnp-8974	512	3	121:651–661	121:651–661	NUM
fnp-8974	512	4	)	)	PUNCT
fnp-8974	512	5	,	,	PUNCT
fnp-8974	512	6	as	as	ADV
fnp-8974	512	7	well	well	ADV
fnp-8974	512	8	as	as	ADP
fnp-8974	512	9	(	(	PUNCT
fnp-8974	512	10	2	2	X
fnp-8974	512	11	)	)	PUNCT
fnp-8974	512	12	cpg30	cpg30	NOUN
fnp-8974	512	13	and	and	CCONJ
fnp-8974	512	14	cpg31	cpg31	NOUN
fnp-8974	512	15	,	,	PUNCT
fnp-8974	512	16	and	and	CCONJ
fnp-8974	512	17	(	(	PUNCT
fnp-8974	512	18	3	3	X
fnp-8974	512	19	)	)	PUNCT
fnp-8974	512	20	cpg84	cpg84	PROPN
fnp-8974	512	21	,	,	PUNCT
fnp-8974	512	22	with	with	ADP
fnp-8974	512	23	cpg31	cpg31	PROPN
fnp-8974	512	24	corresponding	correspond	VERB
fnp-8974	512	25	to	to	ADP
fnp-8974	512	26	cpg10	cpg10	NOUN
fnp-8974	512	27	,	,	PUNCT
fnp-8974	512	28	and	and	CCONJ
fnp-8974	512	29	cpg84	cpg84	PROPN
fnp-8974	512	30	to	to	ADP
fnp-8974	512	31	cpg16	cpg16	PROPN
fnp-8974	512	32	of	of	ADP
fnp-8974	512	33	the	the	DET
fnp-8974	512	34	mgmt	mgmt	ADJ
fnp-8974	512	35	-	-	PUNCT
fnp-8974	512	36	stp27	stp27	NOUN
fnp-8974	512	37	algorithm	algorithm	NOUN
fnp-8974	512	38	.	.	PUNCT
fnp-8974	513	1	comparison	comparison	NOUN
fnp-8974	513	2	of	of	ADP
fnp-8974	513	3	the	the	DET
fnp-8974	513	4	newly	newly	ADV
fnp-8974	513	5	established	establish	VERB
fnp-8974	513	6	ddpcr	ddpcr	NOUN
fnp-8974	513	7	™	™	ADV
fnp-8974	513	8	-based	-based	ADJ
fnp-8974	513	9	assays	assay	NOUN
fnp-8974	513	10	with	with	ADP
fnp-8974	513	11	results	result	NOUN
fnp-8974	513	12	obtained	obtain	VERB
fnp-8974	513	13	by	by	ADP
fnp-8974	513	14	psq	psq	NOUN
fnp-8974	513	15	or	or	CCONJ
fnp-8974	513	16	epicv2	epicv2	PROPN
fnp-8974	513	17	-	-	PUNCT
fnp-8974	513	18	based	base	VERB
fnp-8974	513	19	stp27	stp27	NOUN
fnp-8974	513	20	analysis	analysis	NOUN
fnp-8974	513	21	showed	show	VERB
fnp-8974	513	22	a	a	DET
fnp-8974	513	23	high	high	ADJ
fnp-8974	513	24	degree	degree	NOUN
fnp-8974	513	25	of	of	ADP
fnp-8974	513	26	consistency	consistency	NOUN
fnp-8974	513	27	in	in	ADP
fnp-8974	513	28	the	the	DET
fnp-8974	513	29	methylation	methylation	NOUN
fnp-8974	513	30	levels	level	NOUN
fnp-8974	513	31	detected	detect	VERB
fnp-8974	513	32	at	at	ADP
fnp-8974	513	33	the	the	DET
fnp-8974	513	34	respective	respective	ADJ
fnp-8974	513	35	cpg	cpg	NOUN
fnp-8974	513	36	sites	site	NOUN
fnp-8974	513	37	.	.	PUNCT
fnp-8974	514	1	moreover	moreover	ADV
fnp-8974	514	2	,	,	PUNCT
fnp-8974	514	3	differences	difference	NOUN
fnp-8974	514	4	in	in	ADP
fnp-8974	514	5	methylation	methylation	NOUN
fnp-8974	514	6	status	status	NOUN
fnp-8974	514	7	at	at	ADP
fnp-8974	514	8	the	the	DET
fnp-8974	514	9	distinct	distinct	ADJ
fnp-8974	514	10	cpg	cpg	NOUN
fnp-8974	514	11	sites	site	NOUN
fnp-8974	514	12	interrogated	interrogate	VERB
fnp-8974	514	13	by	by	ADP
fnp-8974	514	14	either	either	DET
fnp-8974	514	15	psq	psq	NOUN
fnp-8974	514	16	or	or	CCONJ
fnp-8974	514	17	stp27	stp27	NOUN
fnp-8974	514	18	were	be	AUX
fnp-8974	514	19	reproduced	reproduce	VERB
fnp-8974	514	20	by	by	ADP
fnp-8974	514	21	the	the	DET
fnp-8974	514	22	distinct	distinct	ADJ
fnp-8974	514	23	ddpcr	ddpcr	NOUN
fnp-8974	514	24	™	™	ADJ
fnp-8974	514	25	assays	assay	NOUN
fnp-8974	514	26	.	.	PUNCT
fnp-8974	515	1	our	our	PRON
fnp-8974	515	2	results	result	NOUN
fnp-8974	515	3	thus	thus	ADV
fnp-8974	515	4	implicate	implicate	VERB
fnp-8974	515	5	ddpcr	ddpcr	ADJ
fnp-8974	515	6	™	™	NOUN
fnp-8974	515	7	as	as	ADP
fnp-8974	515	8	a	a	DET
fnp-8974	515	9	novel	novel	NOUN
fnp-8974	515	10	,	,	PUNCT
fnp-8974	515	11	rapid	rapid	ADJ
fnp-8974	515	12	,	,	PUNCT
fnp-8974	515	13	comprehensive	comprehensive	ADJ
fnp-8974	515	14	and	and	CCONJ
fnp-8974	515	15	quantitative	quantitative	ADJ
fnp-8974	515	16	approach	approach	NOUN
fnp-8974	515	17	for	for	ADP
fnp-8974	515	18	the	the	DET
fnp-8974	515	19	routine	routine	ADJ
fnp-8974	515	20	diagnostic	diagnostic	ADJ
fnp-8974	515	21	determination	determination	NOUN
fnp-8974	515	22	of	of	ADP
fnp-8974	515	23	the	the	DET
fnp-8974	515	24	mgmt	mgmt	PROPN
fnp-8974	515	25	promoter	promoter	NOUN
fnp-8974	515	26	methylation	methylation	NOUN
fnp-8974	515	27	status	status	NOUN
fnp-8974	515	28	in	in	ADP
fnp-8974	515	29	malignant	malignant	ADJ
fnp-8974	515	30	gliomas	glioma	NOUN
fnp-8974	515	31	.	.	PUNCT
fnp-8974	516	1	p40	p40	NOUN
fnp-8974	516	2	free	free	ADJ
fnp-8974	516	3	neuropathol	neuropathol	NOUN
fnp-8974	517	1	6:17:60	6:17:60	NUM
fnp-8974	517	2	exploring	explore	VERB
fnp-8974	517	3	glioblastoma	glioblastoma	NOUN
fnp-8974	517	4	through	through	ADP
fnp-8974	517	5	cpg	cpg	PROPN
fnp-8974	517	6	site	site	NOUN
fnp-8974	517	7	-	-	PUNCT
fnp-8974	517	8	specific	specific	ADJ
fnp-8974	517	9	methylation	methylation	NOUN
fnp-8974	517	10	and	and	CCONJ
fnp-8974	517	11	transcription	transcription	NOUN
fnp-8974	517	12	factor	factor	NOUN
fnp-8974	517	13	occupancy	occupancy	NOUN
fnp-8974	517	14	kimia	kimia	NOUN
fnp-8974	517	15	kafi	kafi	PROPN
fnp-8974	517	16	cheraghi1,2	cheraghi1,2	PROPN
fnp-8974	517	17	,	,	PUNCT
fnp-8974	517	18	michel	michel	PROPN
fnp-8974	517	19	mittelbronn3,4	mittelbronn3,4	PROPN
fnp-8974	517	20	,	,	PUNCT
fnp-8974	517	21	karl	karl	PROPN
fnp-8974	517	22	heinz	heinz	PROPN
fnp-8974	517	23	plate2,5	plate2,5	PROPN
fnp-8974	517	24	,	,	PUNCT
fnp-8974	517	25	joachim	joachim	PROPN
fnp-8974	517	26	steinbach1,5	steinbach1,5	PROPN
fnp-8974	517	27	,	,	PUNCT
fnp-8974	517	28	tanja	tanja	PROPN
fnp-8974	517	29	buhlmann1,2	buhlmann1,2	PROPN
fnp-8974	517	30	,	,	PUNCT
fnp-8974	517	31	ann	ann	PROPN
fnp-8974	517	32	-	-	PUNCT
fnp-8974	517	33	christin	christin	PROPN
fnp-8974	517	34	hau1,2	hau1,2	PROPN
fnp-8974	517	35	1	1	NUM
fnp-8974	517	36	dr	dr	PROPN
fnp-8974	517	37	.	.	PROPN
fnp-8974	517	38	senckenberg	senckenberg	PROPN
fnp-8974	517	39	institute	institute	PROPN
fnp-8974	517	40	of	of	ADP
fnp-8974	517	41	neurooncology	neurooncology	PROPN
fnp-8974	517	42	,	,	PUNCT
fnp-8974	517	43	university	university	NOUN
fnp-8974	517	44	hospital	hospital	NOUN
fnp-8974	517	45	frankfurt	frankfurt	PROPN
fnp-8974	517	46	,	,	PUNCT
fnp-8974	517	47	frankfurt	frankfurt	PROPN
fnp-8974	517	48	am	be	AUX
fnp-8974	517	49	main	main	ADJ
fnp-8974	517	50	,	,	PUNCT
fnp-8974	517	51	germany	germany	PROPN
fnp-8974	517	52	2	2	NUM
fnp-8974	517	53	edinger	edinger	PROPN
fnp-8974	517	54	institute	institute	PROPN
fnp-8974	517	55	,	,	PUNCT
fnp-8974	517	56	institute	institute	PROPN
fnp-8974	517	57	of	of	ADP
fnp-8974	517	58	neurology	neurology	NOUN
fnp-8974	517	59	,	,	PUNCT
fnp-8974	517	60	goethe	goethe	PROPN
fnp-8974	517	61	university	university	PROPN
fnp-8974	517	62	,	,	PUNCT
fnp-8974	517	63	frankfurt	frankfurt	PROPN
fnp-8974	517	64	am	be	AUX
fnp-8974	517	65	main	main	ADJ
fnp-8974	517	66	,	,	PUNCT
fnp-8974	517	67	germany	germany	PROPN
fnp-8974	517	68	3	3	NUM
fnp-8974	517	69	laboratoire	laboratoire	PROPN
fnp-8974	517	70	national	national	PROPN
fnp-8974	517	71	de	de	X
fnp-8974	517	72	santé	santé	X
fnp-8974	517	73	,	,	PUNCT
fnp-8974	517	74	dudelange	dudelange	NOUN
fnp-8974	517	75	,	,	PUNCT
fnp-8974	517	76	luxembourg	luxembourg	PROPN
fnp-8974	517	77	4	4	NUM
fnp-8974	517	78	luxembourg	luxembourg	PROPN
fnp-8974	517	79	institute	institute	PROPN
fnp-8974	517	80	of	of	ADP
fnp-8974	517	81	health	health	PROPN
fnp-8974	517	82	,	,	PUNCT
fnp-8974	517	83	luxembourg	luxembourg	PROPN
fnp-8974	517	84	,	,	PUNCT
fnp-8974	517	85	luxembourg	luxembourg	PROPN
fnp-8974	517	86	5	5	NUM
fnp-8974	517	87	frankfurt	frankfurt	PROPN
fnp-8974	517	88	cancer	cancer	PROPN
fnp-8974	517	89	institute	institute	PROPN
fnp-8974	517	90	,	,	PUNCT
fnp-8974	517	91	frankfurt	frankfurt	PROPN
fnp-8974	517	92	am	be	AUX
fnp-8974	517	93	main	main	ADJ
fnp-8974	517	94	,	,	PUNCT
fnp-8974	517	95	germany	germany	NOUN
fnp-8974	517	96	glioblastoma	glioblastoma	NOUN
fnp-8974	517	97	(	(	PUNCT
fnp-8974	517	98	gb	gb	NOUN
fnp-8974	517	99	)	)	PUNCT
fnp-8974	517	100	is	be	AUX
fnp-8974	517	101	a	a	DET
fnp-8974	517	102	highly	highly	ADV
fnp-8974	517	103	malignant	malignant	ADJ
fnp-8974	517	104	primary	primary	ADJ
fnp-8974	517	105	brain	brain	NOUN
fnp-8974	517	106	tumor	tumor	NOUN
fnp-8974	517	107	that	that	PRON
fnp-8974	517	108	shows	show	VERB
fnp-8974	517	109	extensive	extensive	ADJ
fnp-8974	517	110	heterogeneity	heterogeneity	NOUN
fnp-8974	517	111	and	and	CCONJ
fnp-8974	517	112	invasiveness	invasiveness	NOUN
fnp-8974	517	113	.	.	PUNCT
fnp-8974	518	1	while	while	SCONJ
fnp-8974	518	2	several	several	ADJ
fnp-8974	518	3	studies	study	NOUN
fnp-8974	518	4	highlight	highlight	VERB
fnp-8974	518	5	the	the	DET
fnp-8974	518	6	role	role	NOUN
fnp-8974	518	7	of	of	ADP
fnp-8974	518	8	epigenetic	epigenetic	ADJ
fnp-8974	518	9	alterations	alteration	NOUN
fnp-8974	518	10	in	in	ADP
fnp-8974	518	11	gb	gb	ADP
fnp-8974	518	12	aggressiveness	aggressiveness	NOUN
fnp-8974	518	13	and	and	CCONJ
fnp-8974	518	14	heterogeneity	heterogeneity	NOUN
fnp-8974	518	15	,	,	PUNCT
fnp-8974	518	16	the	the	DET
fnp-8974	518	17	functional	functional	ADJ
fnp-8974	518	18	consequences	consequence	NOUN
fnp-8974	518	19	of	of	ADP
fnp-8974	518	20	individual	individual	ADJ
fnp-8974	518	21	cpg	cpg	PROPN
fnp-8974	518	22	site	site	NOUN
fnp-8974	518	23	methylation	methylation	NOUN
fnp-8974	518	24	remains	remain	VERB
fnp-8974	518	25	poorly	poorly	ADV
fnp-8974	518	26	understood	understand	VERB
fnp-8974	518	27	.	.	PUNCT
fnp-8974	519	1	methylation	methylation	NOUN
fnp-8974	519	2	at	at	ADP
fnp-8974	519	3	cpg	cpg	NOUN
fnp-8974	519	4	sites	site	NOUN
fnp-8974	519	5	can	can	AUX
fnp-8974	519	6	influence	influence	VERB
fnp-8974	519	7	transcription	transcription	NOUN
fnp-8974	519	8	factors	factor	NOUN
fnp-8974	519	9	(	(	PUNCT
fnp-8974	519	10	tf	tf	X
fnp-8974	519	11	)	)	PUNCT
fnp-8974	519	12	binding	bind	VERB
fnp-8974	519	13	,	,	PUNCT
fnp-8974	519	14	thereby	thereby	ADV
fnp-8974	519	15	affecting	affect	VERB
fnp-8974	519	16	gene	gene	NOUN
fnp-8974	519	17	regulation	regulation	NOUN
fnp-8974	519	18	and	and	CCONJ
fnp-8974	519	19	potentially	potentially	ADV
fnp-8974	519	20	impacting	impact	VERB
fnp-8974	519	21	tumor	tumor	NOUN
fnp-8974	519	22	cell	cell	NOUN
fnp-8974	519	23	behavior	behavior	NOUN
fnp-8974	519	24	and	and	CCONJ
fnp-8974	519	25	interactions	interaction	NOUN
fnp-8974	519	26	within	within	ADP
fnp-8974	519	27	the	the	DET
fnp-8974	519	28	tumor	tumor	NOUN
fnp-8974	519	29	microenvironment	microenvironment	NOUN
fnp-8974	519	30	(	(	PUNCT
fnp-8974	519	31	tme	tme	PROPN
fnp-8974	519	32	)	)	PUNCT
fnp-8974	519	33	,	,	PUNCT
fnp-8974	519	34	including	include	VERB
fnp-8974	519	35	invasion	invasion	NOUN
fnp-8974	519	36	.	.	PUNCT
fnp-8974	520	1	the	the	DET
fnp-8974	520	2	present	present	ADJ
fnp-8974	520	3	study	study	NOUN
fnp-8974	520	4	investigates	investigate	VERB
fnp-8974	520	5	the	the	DET
fnp-8974	520	6	impact	impact	NOUN
fnp-8974	520	7	of	of	ADP
fnp-8974	520	8	differential	differential	ADJ
fnp-8974	520	9	cpg	cpg	PROPN
fnp-8974	520	10	site	site	NOUN
fnp-8974	520	11	-	-	PUNCT
fnp-8974	520	12	specific	specific	ADJ
fnp-8974	520	13	methylation	methylation	NOUN
fnp-8974	520	14	on	on	ADP
fnp-8974	520	15	tf	tf	PROPN
fnp-8974	520	16	occupancy	occupancy	NOUN
fnp-8974	520	17	and	and	CCONJ
fnp-8974	520	18	its	its	PRON
fnp-8974	520	19	role	role	NOUN
fnp-8974	520	20	in	in	ADP
fnp-8974	520	21	regulating	regulate	VERB
fnp-8974	520	22	the	the	DET
fnp-8974	520	23	expression	expression	NOUN
fnp-8974	520	24	of	of	ADP
fnp-8974	520	25	chitinase	chitinase	NOUN
fnp-8974	520	26	3	3	NUM
fnp-8974	520	27	-	-	PUNCT
fnp-8974	520	28	like-1	like-1	PROPN
fnp-8974	520	29	(	(	PUNCT
fnp-8974	520	30	chi3l1	chi3l1	NOUN
fnp-8974	520	31	)	)	PUNCT
fnp-8974	520	32	,	,	PUNCT
fnp-8974	520	33	a	a	DET
fnp-8974	520	34	gene	gene	NOUN
fnp-8974	520	35	differentially	differentially	ADV
fnp-8974	520	36	expressed	express	VERB
fnp-8974	520	37	in	in	ADP
fnp-8974	520	38	highly	highly	ADV
fnp-8974	520	39	invasive	invasive	ADJ
fnp-8974	520	40	gb	gb	NOUN
fnp-8974	520	41	stem	stem	NOUN
fnp-8974	520	42	cells	cell	NOUN
fnp-8974	520	43	(	(	PUNCT
fnp-8974	520	44	gscs	gsc	NOUN
fnp-8974	520	45	)	)	PUNCT
fnp-8974	520	46	,	,	PUNCT
fnp-8974	520	47	aiming	aim	VERB
fnp-8974	520	48	to	to	PART
fnp-8974	520	49	examine	examine	VERB
fnp-8974	520	50	the	the	DET
fnp-8974	520	51	role	role	NOUN
fnp-8974	520	52	of	of	ADP
fnp-8974	520	53	methylation	methylation	NOUN
fnp-8974	520	54	in	in	ADP
fnp-8974	520	55	tf	tf	NUM
fnp-8974	520	56	binding	bind	VERB
fnp-8974	520	57	sites	site	NOUN
fnp-8974	520	58	and	and	CCONJ
fnp-8974	520	59	its	its	PRON
fnp-8974	520	60	influence	influence	NOUN
fnp-8974	520	61	on	on	ADP
fnp-8974	520	62	gb	gb	ADP
fnp-8974	520	63	invasiveness	invasiveness	ADJ
fnp-8974	520	64	.	.	PUNCT
fnp-8974	521	1	this	this	DET
fnp-8974	521	2	project	project	NOUN
fnp-8974	521	3	employed	employ	VERB
fnp-8974	521	4	methylation	methylation	NOUN
fnp-8974	521	5	analysis	analysis	NOUN
fnp-8974	521	6	utilizing	utilize	VERB
fnp-8974	521	7	illumina	illumina	PROPN
fnp-8974	521	8	epic	epic	PROPN
fnp-8974	521	9	850k	850k	PROPN
fnp-8974	521	10	array	array	VERB
fnp-8974	521	11	across	across	ADP
fnp-8974	521	12	various	various	ADJ
fnp-8974	521	13	gb	gb	NOUN
fnp-8974	521	14	cell	cell	NOUN
fnp-8974	521	15	lines	line	NOUN
fnp-8974	521	16	,	,	PUNCT
fnp-8974	521	17	revealing	reveal	VERB
fnp-8974	521	18	hypomethylation	hypomethylation	NOUN
fnp-8974	521	19	of	of	ADP
fnp-8974	521	20	chi3l1	chi3l1	NOUN
fnp-8974	521	21	promoter	promoter	NOUN
fnp-8974	521	22	in	in	ADP
fnp-8974	521	23	more	more	ADJ
fnp-8974	521	24	invasive	invasive	ADJ
fnp-8974	521	25	gscs	gsc	NOUN
fnp-8974	521	26	.	.	PUNCT
fnp-8974	522	1	to	to	PART
fnp-8974	522	2	assess	assess	VERB
fnp-8974	522	3	the	the	DET
fnp-8974	522	4	functional	functional	ADJ
fnp-8974	522	5	relevance	relevance	NOUN
fnp-8974	522	6	of	of	ADP
fnp-8974	522	7	this	this	DET
fnp-8974	522	8	finding	finding	NOUN
fnp-8974	522	9	to	to	PART
fnp-8974	522	10	promoter	promoter	NOUN
fnp-8974	522	11	activity	activity	NOUN
fnp-8974	522	12	,	,	PUNCT
fnp-8974	522	13	site	site	NOUN
fnp-8974	522	14	-	-	PUNCT
fnp-8974	522	15	directed	direct	VERB
fnp-8974	522	16	mutagenesis	mutagenesis	NOUN
fnp-8974	522	17	of	of	ADP
fnp-8974	522	18	the	the	DET
fnp-8974	522	19	specific	specific	ADJ
fnp-8974	522	20	cpg	cpg	NOUN
fnp-8974	522	21	sites	site	NOUN
fnp-8974	522	22	was	be	AUX
fnp-8974	522	23	performed	perform	VERB
fnp-8974	522	24	,	,	PUNCT
fnp-8974	522	25	followed	follow	VERB
fnp-8974	522	26	by	by	ADP
fnp-8974	522	27	luciferase	luciferase	NOUN
fnp-8974	522	28	reporter	reporter	NOUN
fnp-8974	522	29	assay	assay	VERB
fnp-8974	522	30	.	.	PUNCT
fnp-8974	523	1	in	in	ADP
fnp-8974	523	2	silico	silico	NOUN
fnp-8974	523	3	motif	motif	NOUN
fnp-8974	523	4	enrichment	enrichment	NOUN
fnp-8974	523	5	analyses	analysis	NOUN
fnp-8974	523	6	identified	identify	VERB
fnp-8974	523	7	tf	tf	PRON
fnp-8974	523	8	binding	bind	VERB
fnp-8974	523	9	motifs	motif	NOUN
fnp-8974	523	10	around	around	ADP
fnp-8974	523	11	the	the	DET
fnp-8974	523	12	candidate	candidate	NOUN
fnp-8974	523	13	cpg	cpg	NOUN
fnp-8974	523	14	sites	site	NOUN
fnp-8974	523	15	,	,	PUNCT
fnp-8974	523	16	suggesting	suggest	VERB
fnp-8974	523	17	that	that	SCONJ
fnp-8974	523	18	methylation	methylation	NOUN
fnp-8974	523	19	status	status	NOUN
fnp-8974	523	20	could	could	AUX
fnp-8974	523	21	modulate	modulate	VERB
fnp-8974	523	22	tf	tf	PRON
fnp-8974	523	23	binding	bind	VERB
fnp-8974	523	24	.	.	PUNCT
fnp-8974	524	1	finally	finally	ADV
fnp-8974	524	2	,	,	PUNCT
fnp-8974	524	3	chromatin	chromatin	NOUN
fnp-8974	524	4	immunoprecipitation	immunoprecipitation	NOUN
fnp-8974	524	5	(	(	PUNCT
fnp-8974	524	6	chip)-qpcr	chip)-qpcr	ADJ
fnp-8974	524	7	experiments	experiment	NOUN
fnp-8974	524	8	were	be	AUX
fnp-8974	524	9	established	establish	VERB
fnp-8974	524	10	to	to	PART
fnp-8974	524	11	confirm	confirm	VERB
fnp-8974	524	12	tf	tf	PRON
fnp-8974	524	13	binding	bind	VERB
fnp-8974	524	14	at	at	ADP
fnp-8974	524	15	differentially	differentially	ADV
fnp-8974	524	16	methylated	methylate	VERB
fnp-8974	524	17	cpg	cpg	NOUN
fnp-8974	524	18	sites	site	NOUN
fnp-8974	524	19	.	.	PUNCT
fnp-8974	525	1	future	future	ADJ
fnp-8974	525	2	work	work	NOUN
fnp-8974	525	3	will	will	AUX
fnp-8974	525	4	examine	examine	VERB
fnp-8974	525	5	the	the	DET
fnp-8974	525	6	role	role	NOUN
fnp-8974	525	7	of	of	ADP
fnp-8974	525	8	these	these	DET
fnp-8974	525	9	tfs	tfs	PROPN
fnp-8974	525	10	in	in	ADP
fnp-8974	525	11	differential	differential	ADJ
fnp-8974	525	12	expression	expression	NOUN
fnp-8974	525	13	of	of	ADP
fnp-8974	525	14	other	other	ADJ
fnp-8974	525	15	genes	gene	NOUN
fnp-8974	525	16	involved	involve	VERB
fnp-8974	525	17	in	in	ADP
fnp-8974	525	18	gb	gb	NOUN
fnp-8974	525	19	invasiveness	invasiveness	ADJ
fnp-8974	525	20	using	use	VERB
fnp-8974	525	21	chip	chip	NOUN
fnp-8974	525	22	sequencing	sequencing	NOUN
fnp-8974	525	23	.	.	PUNCT
fnp-8974	526	1	additionally	additionally	ADV
fnp-8974	526	2	,	,	PUNCT
fnp-8974	526	3	we	we	PRON
fnp-8974	526	4	seek	seek	VERB
fnp-8974	526	5	to	to	PART
fnp-8974	526	6	optimize	optimize	VERB
fnp-8974	526	7	the	the	DET
fnp-8974	526	8	chip	chip	NOUN
fnp-8974	526	9	method	method	NOUN
fnp-8974	526	10	for	for	ADP
fnp-8974	526	11	formalin	formalin	NOUN
fnp-8974	526	12	-	-	PUNCT
fnp-8974	526	13	fixed	fix	VERB
fnp-8974	526	14	paraffin	paraffin	NOUN
fnp-8974	526	15	-	-	PUNCT
fnp-8974	526	16	embedded	embed	VERB
fnp-8974	526	17	tissue	tissue	NOUN
fnp-8974	526	18	,	,	PUNCT
fnp-8974	526	19	as	as	SCONJ
fnp-8974	526	20	they	they	PRON
fnp-8974	526	21	are	be	AUX
fnp-8974	526	22	more	more	ADV
fnp-8974	526	23	physiologically	physiologically	ADV
fnp-8974	526	24	relevant	relevant	ADJ
fnp-8974	526	25	models	model	NOUN
fnp-8974	526	26	.	.	PUNCT
fnp-8974	527	1	p41	p41	PROPN
fnp-8974	527	2	free	free	ADJ
fnp-8974	527	3	neuropathol	neuropathol	NOUN
fnp-8974	527	4	6:17:61	6:17:61	NUM
fnp-8974	527	5	integrated	integrate	VERB
fnp-8974	527	6	analyses	analysis	NOUN
fnp-8974	527	7	reveal	reveal	VERB
fnp-8974	527	8	four	four	NUM
fnp-8974	527	9	distinct	distinct	ADJ
fnp-8974	527	10	molecular	molecular	ADJ
fnp-8974	527	11	subgroups	subgroup	NOUN
fnp-8974	527	12	in	in	ADP
fnp-8974	527	13	corticotroph	corticotroph	ADJ
fnp-8974	527	14	pituitary	pituitary	ADJ
fnp-8974	527	15	neuroendocrine	neuroendocrine	NOUN
fnp-8974	527	16	tumors	tumor	NOUN
fnp-8974	527	17	/	/	SYM
fnp-8974	527	18	adenomas	adenomas	PROPN
fnp-8974	527	19	matthias	matthias	PROPN
fnp-8974	527	20	dottermusch1	dottermusch1	PROPN
fnp-8974	527	21	,	,	PUNCT
fnp-8974	527	22	alice	alice	PROPN
fnp-8974	527	23	ryba2	ryba2	PROPN
fnp-8974	527	24	,	,	PUNCT
fnp-8974	527	25	temor	temor	PROPN
fnp-8974	527	26	rafiq1	rafiq1	PROPN
fnp-8974	527	27	,	,	PUNCT
fnp-8974	527	28	linus	linus	PROPN
fnp-8974	527	29	haberbosch3	haberbosch3	PROPN
fnp-8974	527	30	,	,	PUNCT
fnp-8974	527	31	leonille	leonille	PROPN
fnp-8974	527	32	schweizer4	schweizer4	PROPN
fnp-8974	527	33	,	,	PUNCT
fnp-8974	527	34	mateusz	mateusz	PROPN
fnp-8974	527	35	bujko5	bujko5	PROPN
fnp-8974	527	36	,	,	PUNCT
fnp-8974	527	37	wolfgang	wolfgang	PROPN
fnp-8974	527	38	saeger1,6	saeger1,6	PROPN
fnp-8974	527	39	,	,	PUNCT
fnp-8974	527	40	ulrich	ulrich	PROPN
fnp-8974	527	41	schüller1,7,8	schüller1,7,8	NOUN
fnp-8974	527	42	,	,	PUNCT
fnp-8974	527	43	markus	markus	PROPN
fnp-8974	527	44	glatzel1	glatzel1	PROPN
fnp-8974	527	45	,	,	PUNCT
fnp-8974	527	46	jörg	jörg	PROPN
fnp-8974	527	47	flitsch2	flitsch2	PROPN
fnp-8974	527	48	,	,	PUNCT
fnp-8974	527	49	franz	franz	PROPN
fnp-8974	527	50	ricklefs2	ricklefs2	PROPN
fnp-8974	527	51	,	,	PUNCT
fnp-8974	527	52	julia	julia	PROPN
fnp-8974	527	53	neumann1,9	neumann1,9	PROPN
fnp-8974	527	54	1	1	NUM
fnp-8974	527	55	institute	institute	NOUN
fnp-8974	527	56	of	of	ADP
fnp-8974	527	57	neuropathology	neuropathology	NOUN
fnp-8974	527	58	,	,	PUNCT
fnp-8974	527	59	university	university	NOUN
fnp-8974	527	60	medical	medical	ADJ
fnp-8974	527	61	center	center	PROPN
fnp-8974	527	62	hamburg	hamburg	PROPN
fnp-8974	527	63	-	-	PUNCT
fnp-8974	527	64	eppendorf	eppendorf	PROPN
fnp-8974	527	65	,	,	PUNCT
fnp-8974	527	66	hamburg	hamburg	PROPN
fnp-8974	527	67	,	,	PUNCT
fnp-8974	527	68	germany	germany	PROPN
fnp-8974	527	69	2	2	NUM
fnp-8974	527	70	department	department	NOUN
fnp-8974	527	71	of	of	ADP
fnp-8974	527	72	neurosurgery	neurosurgery	NOUN
fnp-8974	527	73	,	,	PUNCT
fnp-8974	527	74	university	university	NOUN
fnp-8974	527	75	medical	medical	ADJ
fnp-8974	527	76	center	center	PROPN
fnp-8974	527	77	hamburg	hamburg	PROPN
fnp-8974	527	78	-	-	PUNCT
fnp-8974	527	79	eppendorf	eppendorf	PROPN
fnp-8974	527	80	,	,	PUNCT
fnp-8974	527	81	hamburg	hamburg	PROPN
fnp-8974	527	82	,	,	PUNCT
fnp-8974	527	83	germany	germany	PROPN
fnp-8974	527	84	3	3	NUM
fnp-8974	527	85	department	department	PROPN
fnp-8974	527	86	of	of	ADP
fnp-8974	527	87	endocrinology	endocrinology	NOUN
fnp-8974	527	88	and	and	CCONJ
fnp-8974	527	89	metabolic	metabolic	NOUN
fnp-8974	527	90	diseases	disease	NOUN
fnp-8974	527	91	(	(	PUNCT
fnp-8974	527	92	including	include	VERB
fnp-8974	527	93	lipid	lipid	NOUN
fnp-8974	527	94	metabolism	metabolism	NOUN
fnp-8974	527	95	)	)	PUNCT
fnp-8974	527	96	,	,	PUNCT
fnp-8974	527	97	charité	charité	PROPN
fnp-8974	527	98	university	university	NOUN
fnp-8974	527	99	medicine	medicine	NOUN
fnp-8974	527	100	,	,	PUNCT
fnp-8974	527	101	berlin	berlin	PROPN
fnp-8974	527	102	,	,	PUNCT
fnp-8974	527	103	germany	germany	PROPN
fnp-8974	527	104	4	4	NUM
fnp-8974	527	105	edinger	edinger	PROPN
fnp-8974	527	106	institute	institute	PROPN
fnp-8974	527	107	(	(	PUNCT
fnp-8974	527	108	institute	institute	PROPN
fnp-8974	527	109	of	of	ADP
fnp-8974	527	110	neurology	neurology	NOUN
fnp-8974	527	111	)	)	PUNCT
fnp-8974	527	112	,	,	PUNCT
fnp-8974	527	113	university	university	NOUN
fnp-8974	527	114	hospital	hospital	NOUN
fnp-8974	527	115	frankfurt	frankfurt	PROPN
fnp-8974	527	116	,	,	PUNCT
fnp-8974	527	117	goethe	goethe	PROPN
fnp-8974	527	118	university	university	PROPN
fnp-8974	527	119	,	,	PUNCT
fnp-8974	527	120	frankfurt	frankfurt	PROPN
fnp-8974	527	121	am	be	AUX
fnp-8974	527	122	main	main	ADJ
fnp-8974	527	123	,	,	PUNCT
fnp-8974	527	124	germany	germany	PROPN
fnp-8974	527	125	5	5	NUM
fnp-8974	527	126	department	department	NOUN
fnp-8974	527	127	of	of	ADP
fnp-8974	527	128	molecular	molecular	ADJ
fnp-8974	527	129	and	and	CCONJ
fnp-8974	527	130	translational	translational	ADJ
fnp-8974	527	131	oncology	oncology	NOUN
fnp-8974	527	132	,	,	PUNCT
fnp-8974	527	133	maria	maria	PROPN
fnp-8974	527	134	sklodowska	sklodowska	PROPN
fnp-8974	527	135	-	-	PUNCT
fnp-8974	527	136	curie	curie	PROPN
fnp-8974	527	137	national	national	PROPN
fnp-8974	527	138	research	research	PROPN
fnp-8974	527	139	institute	institute	PROPN
fnp-8974	527	140	of	of	ADP
fnp-8974	527	141	oncology	oncology	PROPN
fnp-8974	527	142	,	,	PUNCT
fnp-8974	527	143	warsaw	warsaw	PROPN
fnp-8974	527	144	,	,	PUNCT
fnp-8974	527	145	poland	poland	PROPN
fnp-8974	527	146	6	6	NUM
fnp-8974	527	147	institute	institute	NOUN
fnp-8974	527	148	of	of	ADP
fnp-8974	527	149	pathology	pathology	PROPN
fnp-8974	527	150	,	,	PUNCT
fnp-8974	527	151	university	university	NOUN
fnp-8974	527	152	medical	medical	ADJ
fnp-8974	527	153	center	center	PROPN
fnp-8974	527	154	hamburg	hamburg	PROPN
fnp-8974	527	155	-	-	PUNCT
fnp-8974	527	156	eppendorf	eppendorf	PROPN
fnp-8974	527	157	,	,	PUNCT
fnp-8974	527	158	hamburg	hamburg	PROPN
fnp-8974	527	159	,	,	PUNCT
fnp-8974	527	160	germany	germany	PROPN
fnp-8974	527	161	7	7	NUM
fnp-8974	527	162	pediatric	pediatric	ADJ
fnp-8974	527	163	hematology	hematology	NOUN
fnp-8974	527	164	and	and	CCONJ
fnp-8974	527	165	oncology	oncology	NOUN
fnp-8974	527	166	,	,	PUNCT
fnp-8974	527	167	university	university	NOUN
fnp-8974	527	168	medical	medical	ADJ
fnp-8974	527	169	center	center	PROPN
fnp-8974	527	170	hamburg	hamburg	PROPN
fnp-8974	527	171	-	-	PUNCT
fnp-8974	527	172	eppendorf	eppendorf	PROPN
fnp-8974	527	173	,	,	PUNCT
fnp-8974	527	174	hamburg	hamburg	PROPN
fnp-8974	527	175	,	,	PUNCT
fnp-8974	527	176	germany	germany	PROPN
fnp-8974	527	177	8	8	NUM
fnp-8974	527	178	children	child	NOUN
fnp-8974	527	179	's	's	PART
fnp-8974	527	180	cancer	cancer	NOUN
fnp-8974	527	181	research	research	NOUN
fnp-8974	527	182	center	center	PROPN
fnp-8974	527	183	hamburg	hamburg	PROPN
fnp-8974	527	184	,	,	PUNCT
fnp-8974	527	185	hamburg	hamburg	PROPN
fnp-8974	527	186	,	,	PUNCT
fnp-8974	527	187	germany	germany	PROPN
fnp-8974	527	188	9	9	NUM
fnp-8974	527	189	center	center	NOUN
fnp-8974	527	190	for	for	ADP
fnp-8974	527	191	molecular	molecular	ADJ
fnp-8974	527	192	neurobiology	neurobiology	NOUN
fnp-8974	527	193	(	(	PUNCT
fnp-8974	527	194	zmnh	zmnh	NOUN
fnp-8974	527	195	)	)	PUNCT
fnp-8974	527	196	,	,	PUNCT
fnp-8974	527	197	university	university	NOUN
fnp-8974	527	198	medical	medical	ADJ
fnp-8974	527	199	center	center	PROPN
fnp-8974	527	200	hamburg	hamburg	PROPN
fnp-8974	527	201	-	-	PUNCT
fnp-8974	527	202	eppendorf	eppendorf	PROPN
fnp-8974	527	203	,	,	PUNCT
fnp-8974	527	204	hamburg	hamburg	PROPN
fnp-8974	527	205	,	,	PUNCT
fnp-8974	527	206	germany	germany	PROPN
fnp-8974	527	207	background	background	NOUN
fnp-8974	527	208	:	:	PUNCT
fnp-8974	527	209	corticotroph	corticotroph	ADJ
fnp-8974	527	210	pituitary	pituitary	ADJ
fnp-8974	527	211	neuroendocrine	neuroendocrine	NOUN
fnp-8974	527	212	tumors	tumor	NOUN
fnp-8974	527	213	(	(	PUNCT
fnp-8974	527	214	pitnets	pitnet	NOUN
fnp-8974	527	215	/	/	SYM
fnp-8974	527	216	adenomas	adenoma	NOUN
fnp-8974	527	217	)	)	PUNCT
fnp-8974	527	218	are	be	AUX
fnp-8974	527	219	common	common	ADJ
fnp-8974	527	220	sellar	sellar	ADJ
fnp-8974	527	221	neoplasms	neoplasm	NOUN
fnp-8974	527	222	with	with	ADP
fnp-8974	527	223	variable	variable	ADJ
fnp-8974	527	224	clinical	clinical	ADJ
fnp-8974	527	225	presentations	presentation	NOUN
fnp-8974	527	226	.	.	PUNCT
fnp-8974	528	1	according	accord	VERB
fnp-8974	528	2	to	to	ADP
fnp-8974	528	3	the	the	DET
fnp-8974	528	4	current	current	NOUN
fnp-8974	528	5	who	who	PRON
fnp-8974	528	6	classification	classification	VERB
fnp-8974	528	7	,	,	PUNCT
fnp-8974	528	8	tumor	tumor	NOUN
fnp-8974	528	9	subtyping	subtyping	NOUN
fnp-8974	528	10	is	be	AUX
fnp-8974	528	11	based	base	VERB
fnp-8974	528	12	on	on	ADP
fnp-8974	528	13	histopathology	histopathology	NOUN
fnp-8974	528	14	and	and	CCONJ
fnp-8974	528	15	comprises	comprise	VERB
fnp-8974	528	16	subtypes	subtype	NOUN
fnp-8974	528	17	with	with	ADP
fnp-8974	528	18	either	either	CCONJ
fnp-8974	528	19	sparse	sparse	ADJ
fnp-8974	528	20	or	or	CCONJ
fnp-8974	528	21	dense	dense	ADJ
fnp-8974	528	22	granulation	granulation	NOUN
fnp-8974	528	23	as	as	ADV
fnp-8974	528	24	well	well	ADV
fnp-8974	528	25	as	as	ADP
fnp-8974	528	26	crooke	crooke	NOUN
fnp-8974	528	27	cell	cell	NOUN
fnp-8974	528	28	tumors	tumor	NOUN
fnp-8974	528	29	.	.	PUNCT
fnp-8974	529	1	previous	previous	ADJ
fnp-8974	529	2	studies	study	NOUN
fnp-8974	529	3	on	on	ADP
fnp-8974	529	4	confined	confine	VERB
fnp-8974	529	5	case	case	NOUN
fnp-8974	529	6	series	series	NOUN
fnp-8974	529	7	have	have	AUX
fnp-8974	529	8	reported	report	VERB
fnp-8974	529	9	three	three	NUM
fnp-8974	529	10	distinct	distinct	ADJ
fnp-8974	529	11	molecular	molecular	ADJ
fnp-8974	529	12	profiles	profile	NOUN
fnp-8974	529	13	in	in	ADP
fnp-8974	529	14	corticotroph	corticotroph	ADJ
fnp-8974	529	15	pitnets	pitnet	NOUN
fnp-8974	529	16	.	.	PUNCT
fnp-8974	530	1	these	these	DET
fnp-8974	530	2	molecular	molecular	ADJ
fnp-8974	530	3	profiles	profile	NOUN
fnp-8974	530	4	primarily	primarily	ADV
fnp-8974	530	5	related	relate	VERB
fnp-8974	530	6	to	to	ADP
fnp-8974	530	7	usp8	usp8	PROPN
fnp-8974	530	8	-	-	PUNCT
fnp-8974	530	9	mutation	mutation	NOUN
fnp-8974	530	10	status	status	NOUN
fnp-8974	530	11	and	and	CCONJ
fnp-8974	530	12	gata3	gata3	NOUN
fnp-8974	530	13	-	-	PUNCT
fnp-8974	530	14	expression	expression	NOUN
fnp-8974	530	15	levels	level	NOUN
fnp-8974	530	16	,	,	PUNCT
fnp-8974	530	17	while	while	SCONJ
fnp-8974	530	18	their	their	PRON
fnp-8974	530	19	alignment	alignment	NOUN
fnp-8974	530	20	with	with	ADP
fnp-8974	530	21	the	the	DET
fnp-8974	530	22	established	establish	VERB
fnp-8974	530	23	who	who	PRON
fnp-8974	530	24	subtypes	subtype	NOUN
fnp-8974	530	25	was	be	AUX
fnp-8974	530	26	limited	limited	ADJ
fnp-8974	530	27	.	.	PUNCT
fnp-8974	531	1	objective	objective	NOUN
fnp-8974	531	2	:	:	PUNCT
fnp-8974	531	3	in	in	ADP
fnp-8974	531	4	this	this	DET
fnp-8974	531	5	ongoing	ongoing	ADJ
fnp-8974	531	6	work	work	NOUN
fnp-8974	531	7	,	,	PUNCT
fnp-8974	531	8	we	we	PRON
fnp-8974	531	9	aim	aim	VERB
fnp-8974	531	10	to	to	PART
fnp-8974	531	11	further	far	ADV
fnp-8974	531	12	explore	explore	VERB
fnp-8974	531	13	molecular	molecular	ADJ
fnp-8974	531	14	subgroups	subgroup	NOUN
fnp-8974	531	15	of	of	ADP
fnp-8974	531	16	corticotroph	corticotroph	ADJ
fnp-8974	531	17	pitnets	pitnet	NOUN
fnp-8974	531	18	and	and	CCONJ
fnp-8974	531	19	their	their	PRON
fnp-8974	531	20	clinical	clinical	ADJ
fnp-8974	531	21	relevance	relevance	NOUN
fnp-8974	531	22	.	.	PUNCT
fnp-8974	532	1	methods	method	NOUN
fnp-8974	532	2	:	:	PUNCT
fnp-8974	532	3	we	we	PRON
fnp-8974	532	4	compiled	compile	VERB
fnp-8974	532	5	previously	previously	ADV
fnp-8974	532	6	published	publish	VERB
fnp-8974	532	7	and	and	CCONJ
fnp-8974	532	8	publicly	publicly	ADV
fnp-8974	532	9	available	available	ADJ
fnp-8974	532	10	global	global	ADJ
fnp-8974	532	11	epigenomic	epigenomic	ADJ
fnp-8974	532	12	and/or	and/or	CCONJ
fnp-8974	532	13	transcriptomic	transcriptomic	ADJ
fnp-8974	532	14	data	datum	NOUN
fnp-8974	532	15	of	of	ADP
fnp-8974	532	16	171	171	NUM
fnp-8974	532	17	corticotroph	corticotroph	ADJ
fnp-8974	532	18	pitnets	pitnet	NOUN
fnp-8974	532	19	,	,	PUNCT
fnp-8974	532	20	derived	derive	VERB
fnp-8974	532	21	from	from	ADP
fnp-8974	532	22	a	a	DET
fnp-8974	532	23	total	total	NOUN
fnp-8974	532	24	of	of	ADP
fnp-8974	532	25	7	7	NUM
fnp-8974	532	26	independent	independent	ADJ
fnp-8974	532	27	studies	study	NOUN
fnp-8974	532	28	.	.	PUNCT
fnp-8974	533	1	gap	gap	NOUN
fnp-8974	533	2	statistics	statistic	NOUN
fnp-8974	533	3	and	and	CCONJ
fnp-8974	533	4	consensus	consensus	NOUN
fnp-8974	533	5	clustering	clustering	NOUN
fnp-8974	533	6	were	be	AUX
fnp-8974	533	7	applied	apply	VERB
fnp-8974	533	8	to	to	PART
fnp-8974	533	9	delineate	delineate	VERB
fnp-8974	533	10	molecular	molecular	ADJ
fnp-8974	533	11	subgroups	subgroup	NOUN
fnp-8974	533	12	within	within	ADP
fnp-8974	533	13	the	the	DET
fnp-8974	533	14	compiled	compile	VERB
fnp-8974	533	15	datasets	dataset	NOUN
fnp-8974	533	16	.	.	PUNCT
fnp-8974	534	1	results	result	NOUN
fnp-8974	534	2	:	:	PUNCT
fnp-8974	534	3	based	base	VERB
fnp-8974	534	4	on	on	ADP
fnp-8974	534	5	epigenomic	epigenomic	ADJ
fnp-8974	534	6	as	as	ADV
fnp-8974	534	7	well	well	ADV
fnp-8974	534	8	as	as	ADP
fnp-8974	534	9	transcriptomic	transcriptomic	ADJ
fnp-8974	534	10	data	datum	NOUN
fnp-8974	534	11	,	,	PUNCT
fnp-8974	534	12	corticotroph	corticotroph	ADJ
fnp-8974	534	13	pitnets	pitnet	NOUN
fnp-8974	534	14	separated	separate	VERB
fnp-8974	534	15	into	into	ADP
fnp-8974	534	16	four	four	NUM
fnp-8974	534	17	distinct	distinct	ADJ
fnp-8974	534	18	molecular	molecular	ADJ
fnp-8974	534	19	subgroups	subgroup	NOUN
fnp-8974	534	20	,	,	PUNCT
fnp-8974	534	21	preliminarily	preliminarily	ADV
fnp-8974	534	22	named	name	VERB
fnp-8974	534	23	subgroups	subgroup	NOUN
fnp-8974	534	24	1–4	1–4	PRON
fnp-8974	534	25	.	.	PUNCT
fnp-8974	535	1	usp8	usp8	PROPN
fnp-8974	535	2	-	-	PUNCT
fnp-8974	535	3	wildtype	wildtype	PROPN
fnp-8974	535	4	and	and	CCONJ
fnp-8974	535	5	gata3	gata3	NOUN
fnp-8974	535	6	-	-	PUNCT
fnp-8974	535	7	negative	negative	ADJ
fnp-8974	535	8	tumors	tumor	NOUN
fnp-8974	535	9	split	split	VERB
fnp-8974	535	10	into	into	ADP
fnp-8974	535	11	subgroups	subgroup	NOUN
fnp-8974	535	12	1	1	NUM
fnp-8974	535	13	and	and	CCONJ
fnp-8974	535	14	2	2	NUM
fnp-8974	535	15	.	.	PUNCT
fnp-8974	536	1	usp8	usp8	PROPN
fnp-8974	536	2	-	-	PUNCT
fnp-8974	536	3	wildtype	wildtype	PROPN
fnp-8974	536	4	tumors	tumor	NOUN
fnp-8974	536	5	with	with	ADP
fnp-8974	536	6	increased	increase	VERB
fnp-8974	536	7	gata3	gata3	NOUN
fnp-8974	536	8	expression	expression	NOUN
fnp-8974	536	9	were	be	AUX
fnp-8974	536	10	mainly	mainly	ADV
fnp-8974	536	11	found	find	VERB
fnp-8974	536	12	in	in	ADP
fnp-8974	536	13	subgroup	subgroup	NOUN
fnp-8974	536	14	3	3	NUM
fnp-8974	536	15	.	.	PUNCT
fnp-8974	537	1	usp8	usp8	PROPN
fnp-8974	537	2	-	-	PUNCT
fnp-8974	537	3	mutated	mutate	VERB
fnp-8974	537	4	tumors	tumor	NOUN
fnp-8974	537	5	with	with	ADP
fnp-8974	537	6	increased	increase	VERB
fnp-8974	537	7	sstr5	sstr5	NOUN
fnp-8974	537	8	expression	expression	NOUN
fnp-8974	537	9	were	be	AUX
fnp-8974	537	10	predominantly	predominantly	ADV
fnp-8974	537	11	aggregated	aggregate	VERB
fnp-8974	537	12	in	in	ADP
fnp-8974	537	13	subgroup	subgroup	NOUN
fnp-8974	537	14	4	4	NUM
fnp-8974	537	15	.	.	PUNCT
fnp-8974	538	1	preliminary	preliminary	ADJ
fnp-8974	538	2	investigations	investigation	NOUN
fnp-8974	538	3	indicated	indicate	VERB
fnp-8974	538	4	that	that	SCONJ
fnp-8974	538	5	these	these	DET
fnp-8974	538	6	four	four	NUM
fnp-8974	538	7	molecular	molecular	ADJ
fnp-8974	538	8	subgroups	subgroup	NOUN
fnp-8974	538	9	enable	enable	VERB
fnp-8974	538	10	improved	improved	ADJ
fnp-8974	538	11	prognostic	prognostic	ADJ
fnp-8974	538	12	stratification	stratification	NOUN
fnp-8974	538	13	beyond	beyond	ADP
fnp-8974	538	14	current	current	ADJ
fnp-8974	538	15	concepts	concept	NOUN
fnp-8974	538	16	.	.	PUNCT
fnp-8974	539	1	conclusions	conclusion	NOUN
fnp-8974	539	2	:	:	PUNCT
fnp-8974	539	3	our	our	PRON
fnp-8974	539	4	findings	finding	NOUN
fnp-8974	539	5	demonstrate	demonstrate	VERB
fnp-8974	539	6	that	that	SCONJ
fnp-8974	539	7	corticotroph	corticotroph	PROPN
fnp-8974	539	8	pitnets	pitnet	NOUN
fnp-8974	539	9	segregate	segregate	VERB
fnp-8974	539	10	into	into	ADP
fnp-8974	539	11	four	four	NUM
fnp-8974	539	12	molecular	molecular	ADJ
fnp-8974	539	13	subgroups	subgroup	NOUN
fnp-8974	539	14	.	.	PUNCT
fnp-8974	540	1	ongoing	ongoing	ADJ
fnp-8974	540	2	investigations	investigation	NOUN
fnp-8974	540	3	including	include	VERB
fnp-8974	540	4	detailed	detail	VERB
fnp-8974	540	5	clinicopathological	clinicopathological	ADJ
fnp-8974	540	6	characterizations	characterization	NOUN
fnp-8974	540	7	of	of	ADP
fnp-8974	540	8	each	each	DET
fnp-8974	540	9	subgroup	subgroup	NOUN
fnp-8974	540	10	have	have	VERB
fnp-8974	540	11	the	the	DET
fnp-8974	540	12	potential	potential	NOUN
fnp-8974	540	13	to	to	PART
fnp-8974	540	14	improve	improve	VERB
fnp-8974	540	15	the	the	DET
fnp-8974	540	16	existing	exist	VERB
fnp-8974	540	17	histopathological	histopathological	ADJ
fnp-8974	540	18	classification	classification	NOUN
fnp-8974	540	19	framework	framework	NOUN
fnp-8974	540	20	in	in	ADP
fnp-8974	540	21	corticotroph	corticotroph	ADJ
fnp-8974	540	22	pitnets	pitnet	NOUN
fnp-8974	540	23	.	.	PUNCT
fnp-8974	541	1	p42	p42	PROPN
fnp-8974	541	2	free	free	ADJ
fnp-8974	541	3	neuropathol	neuropathol	NOUN
fnp-8974	541	4	6:17:63	6:17:63	NUM
fnp-8974	541	5	harnessing	harness	VERB
fnp-8974	541	6	stress	stress	ADJ
fnp-8974	541	7	adaptive	adaptive	ADJ
fnp-8974	541	8	response	response	NOUN
fnp-8974	541	9	mechanisms	mechanism	NOUN
fnp-8974	541	10	for	for	ADP
fnp-8974	541	11	pharmacological	pharmacological	ADJ
fnp-8974	541	12	targeting	targeting	NOUN
fnp-8974	541	13	of	of	ADP
fnp-8974	541	14	cancer	cancer	NOUN
fnp-8974	541	15	laura	laura	NOUN
fnp-8974	541	16	hruby1	hruby1	PROPN
fnp-8974	541	17	,	,	PUNCT
fnp-8974	541	18	david	david	PROPN
fnp-8974	541	19	bickel2	bickel2	PROPN
fnp-8974	541	20	,	,	PUNCT
fnp-8974	541	21	laura	laura	PROPN
fnp-8974	541	22	drobe1	drobe1	PROPN
fnp-8974	541	23	,	,	PUNCT
fnp-8974	541	24	holger	holger	PROPN
fnp-8974	541	25	gohlke2	gohlke2	PROPN
fnp-8974	541	26	,	,	PUNCT
fnp-8974	541	27	dieter	dieter	NOUN
fnp-8974	541	28	willbold3	willbold3	PROPN
fnp-8974	541	29	,	,	PUNCT
fnp-8974	541	30	guido	guido	NOUN
fnp-8974	541	31	reifenberger1	reifenberger1	PROPN
fnp-8974	541	32	,	,	PUNCT
fnp-8974	541	33	gabriel	gabriel	PROPN
fnp-8974	541	34	leprivier1	leprivier1	PROPN
fnp-8974	541	35	1	1	NUM
fnp-8974	541	36	universitätsklinikum	universitätsklinikum	NOUN
fnp-8974	541	37	düsseldorf	düsseldorf	PROPN
fnp-8974	541	38	,	,	PUNCT
fnp-8974	541	39	institut	institut	PROPN
fnp-8974	541	40	für	für	PROPN
fnp-8974	541	41	neuropathologie	neuropathologie	PROPN
fnp-8974	541	42	,	,	PUNCT
fnp-8974	541	43	düsseldorf	düsseldorf	PROPN
fnp-8974	541	44	,	,	PUNCT
fnp-8974	541	45	germany	germany	PROPN
fnp-8974	541	46	2	2	NUM
fnp-8974	541	47	heinrich	heinrich	PROPN
fnp-8974	541	48	-	-	PUNCT
fnp-8974	541	49	heine	heine	NOUN
fnp-8974	541	50	-	-	PUNCT
fnp-8974	541	51	universität	universität	NOUN
fnp-8974	541	52	,	,	PUNCT
fnp-8974	541	53	institut	institut	PROPN
fnp-8974	541	54	für	für	PROPN
fnp-8974	541	55	pharmazeutische	pharmazeutische	PROPN
fnp-8974	541	56	und	und	VERB
fnp-8974	541	57	medizinische	medizinische	PROPN
fnp-8974	541	58	chemie	chemie	PROPN
fnp-8974	541	59	,	,	PUNCT
fnp-8974	541	60	düsseldorf	düsseldorf	PROPN
fnp-8974	541	61	,	,	PUNCT
fnp-8974	541	62	germany	germany	PROPN
fnp-8974	541	63	3	3	NUM
fnp-8974	541	64	heinrich	heinrich	PROPN
fnp-8974	541	65	-	-	PUNCT
fnp-8974	541	66	heine	heine	PROPN
fnp-8974	541	67	-	-	PUNCT
fnp-8974	541	68	universität	universität	NOUN
fnp-8974	541	69	,	,	PUNCT
fnp-8974	541	70	institut	institut	PROPN
fnp-8974	541	71	für	für	PROPN
fnp-8974	541	72	physikalische	physikalische	PROPN
fnp-8974	541	73	biologie	biologie	PROPN
fnp-8974	541	74	,	,	PUNCT
fnp-8974	541	75	düsseldorf	düsseldorf	PROPN
fnp-8974	541	76	,	,	PUNCT
fnp-8974	541	77	germany	germany	PROPN
fnp-8974	541	78	brain	brain	NOUN
fnp-8974	541	79	cancer	cancer	NOUN
fnp-8974	541	80	cells	cell	NOUN
fnp-8974	541	81	are	be	AUX
fnp-8974	541	82	subjected	subject	VERB
fnp-8974	541	83	to	to	ADP
fnp-8974	541	84	metabolic	metabolic	NOUN
fnp-8974	541	85	stress	stress	NOUN
fnp-8974	541	86	,	,	PUNCT
fnp-8974	541	87	such	such	ADJ
fnp-8974	541	88	as	as	ADP
fnp-8974	541	89	hypoxia	hypoxia	NOUN
fnp-8974	541	90	and	and	CCONJ
fnp-8974	541	91	glucose	glucose	NOUN
fnp-8974	541	92	restriction	restriction	NOUN
fnp-8974	541	93	,	,	PUNCT
fnp-8974	541	94	due	due	ADP
fnp-8974	541	95	to	to	ADP
fnp-8974	541	96	defective	defective	ADJ
fnp-8974	541	97	tumor	tumor	NOUN
fnp-8974	541	98	vasculature	vasculature	NOUN
fnp-8974	541	99	.	.	PUNCT
fnp-8974	542	1	this	this	DET
fnp-8974	542	2	forces	force	NOUN
fnp-8974	542	3	brain	brain	VERB
fnp-8974	542	4	cancer	cancer	NOUN
fnp-8974	542	5	cells	cell	NOUN
fnp-8974	542	6	to	to	PART
fnp-8974	542	7	evolve	evolve	VERB
fnp-8974	542	8	adaptive	adaptive	ADJ
fnp-8974	542	9	mechanisms	mechanism	NOUN
fnp-8974	542	10	to	to	PART
fnp-8974	542	11	reprogram	reprogram	VERB
fnp-8974	542	12	their	their	PRON
fnp-8974	542	13	metabolism	metabolism	NOUN
fnp-8974	542	14	,	,	PUNCT
fnp-8974	542	15	which	which	PRON
fnp-8974	542	16	includes	include	VERB
fnp-8974	542	17	inhibition	inhibition	NOUN
fnp-8974	542	18	of	of	ADP
fnp-8974	542	19	mrna	mrna	PROPN
fnp-8974	542	20	translation	translation	NOUN
fnp-8974	542	21	—	—	PUNCT
fnp-8974	542	22	a	a	DET
fnp-8974	542	23	highly	highly	ADV
fnp-8974	542	24	energetic	energetic	ADJ
fnp-8974	542	25	process	process	NOUN
fnp-8974	542	26	.	.	PUNCT
fnp-8974	543	1	the	the	DET
fnp-8974	543	2	rate	rate	NOUN
fnp-8974	543	3	of	of	ADP
fnp-8974	543	4	mrna	mrna	PROPN
fnp-8974	543	5	translation	translation	NOUN
fnp-8974	543	6	is	be	AUX
fnp-8974	543	7	controlled	control	VERB
fnp-8974	543	8	by	by	ADP
fnp-8974	543	9	the	the	DET
fnp-8974	543	10	mechanistic	mechanistic	ADJ
fnp-8974	543	11	target	target	NOUN
fnp-8974	543	12	of	of	ADP
fnp-8974	543	13	rapamycin	rapamycin	NOUN
fnp-8974	543	14	(	(	PUNCT
fnp-8974	543	15	mtor)/	mtor)/	NOUN
fnp-8974	543	16	eukaryotic	eukaryotic	ADJ
fnp-8974	543	17	initiation	initiation	NOUN
fnp-8974	543	18	factor	factor	NOUN
fnp-8974	543	19	4e	4e	NOUN
fnp-8974	543	20	binding	bind	VERB
fnp-8974	543	21	protein	protein	NOUN
fnp-8974	543	22	(	(	PUNCT
fnp-8974	543	23	4ebp	4ebp	NOUN
fnp-8974	543	24	)	)	PUNCT
fnp-8974	543	25	pathway	pathway	NOUN
fnp-8974	543	26	according	accord	VERB
fnp-8974	543	27	to	to	ADP
fnp-8974	543	28	glucose	glucose	NOUN
fnp-8974	543	29	concentrations	concentration	NOUN
fnp-8974	543	30	.	.	PUNCT
fnp-8974	544	1	glucose	glucose	NOUN
fnp-8974	544	2	starvation	starvation	NOUN
fnp-8974	544	3	blocks	block	NOUN
fnp-8974	544	4	mtor	mtor	NOUN
fnp-8974	544	5	,	,	PUNCT
fnp-8974	544	6	which	which	PRON
fnp-8974	544	7	in	in	ADP
fnp-8974	544	8	turn	turn	NOUN
fnp-8974	544	9	leads	lead	VERB
fnp-8974	544	10	to	to	ADP
fnp-8974	544	11	4ebp1	4ebp1	NUM
fnp-8974	544	12	activation	activation	NOUN
fnp-8974	544	13	.	.	PUNCT
fnp-8974	545	1	this	this	DET
fnp-8974	545	2	results	result	VERB
fnp-8974	545	3	in	in	ADP
fnp-8974	545	4	the	the	DET
fnp-8974	545	5	inhibition	inhibition	NOUN
fnp-8974	545	6	of	of	ADP
fnp-8974	545	7	mrna	mrna	PROPN
fnp-8974	545	8	translation	translation	NOUN
fnp-8974	545	9	initiation	initiation	NOUN
fnp-8974	545	10	as	as	SCONJ
fnp-8974	545	11	4ebp1	4ebp1	PRON
fnp-8974	545	12	binds	bind	VERB
fnp-8974	545	13	to	to	PART
fnp-8974	545	14	and	and	CCONJ
fnp-8974	545	15	blocks	block	VERB
fnp-8974	545	16	the	the	DET
fnp-8974	545	17	translation	translation	NOUN
fnp-8974	545	18	initiation	initiation	NOUN
fnp-8974	545	19	factor	factor	NOUN
fnp-8974	545	20	eif4e	eif4e	PROPN
fnp-8974	545	21	.	.	PUNCT
fnp-8974	546	1	we	we	PRON
fnp-8974	546	2	found	find	VERB
fnp-8974	546	3	that	that	SCONJ
fnp-8974	546	4	high	high	ADJ
fnp-8974	546	5	4ebp1	4ebp1	NOUN
fnp-8974	546	6	expression	expression	NOUN
fnp-8974	546	7	is	be	AUX
fnp-8974	546	8	a	a	DET
fnp-8974	546	9	factor	factor	NOUN
fnp-8974	546	10	of	of	ADP
fnp-8974	546	11	poor	poor	ADJ
fnp-8974	546	12	prognosis	prognosis	NOUN
fnp-8974	546	13	in	in	ADP
fnp-8974	546	14	glioblastoma	glioblastoma	NOUN
fnp-8974	546	15	and	and	CCONJ
fnp-8974	546	16	medulloblastoma	medulloblastoma	NOUN
fnp-8974	546	17	.	.	PUNCT
fnp-8974	547	1	furthermore	furthermore	ADV
fnp-8974	547	2	,	,	PUNCT
fnp-8974	547	3	we	we	PRON
fnp-8974	547	4	demonstrated	demonstrate	VERB
fnp-8974	547	5	that	that	SCONJ
fnp-8974	547	6	4ebp1	4ebp1	PRON
fnp-8974	547	7	protects	protect	VERB
fnp-8974	547	8	glioblastoma	glioblastoma	NOUN
fnp-8974	547	9	and	and	CCONJ
fnp-8974	547	10	medulloblastoma	medulloblastoma	ADJ
fnp-8974	547	11	cells	cell	NOUN
fnp-8974	547	12	under	under	ADP
fnp-8974	547	13	glucose	glucose	NOUN
fnp-8974	547	14	starvation	starvation	NOUN
fnp-8974	547	15	and	and	CCONJ
fnp-8974	547	16	promotes	promote	VERB
fnp-8974	547	17	tumorigenicity	tumorigenicity	NOUN
fnp-8974	547	18	both	both	CCONJ
fnp-8974	547	19	in	in	ADP
fnp-8974	547	20	vitro	vitro	X
fnp-8974	547	21	and	and	CCONJ
fnp-8974	547	22	in	in	ADP
fnp-8974	547	23	vivo	vivo	NOUN
fnp-8974	547	24	.	.	PUNCT
fnp-8974	548	1	these	these	DET
fnp-8974	548	2	findings	finding	NOUN
fnp-8974	548	3	support	support	VERB
fnp-8974	548	4	that	that	SCONJ
fnp-8974	548	5	4ebp1	4ebp1	PRON
fnp-8974	548	6	may	may	AUX
fnp-8974	548	7	be	be	AUX
fnp-8974	548	8	a	a	DET
fnp-8974	548	9	potential	potential	ADJ
fnp-8974	548	10	therapeutic	therapeutic	ADJ
fnp-8974	548	11	target	target	NOUN
fnp-8974	548	12	in	in	ADP
fnp-8974	548	13	glioblastoma	glioblastoma	NOUN
fnp-8974	548	14	and	and	CCONJ
fnp-8974	548	15	medulloblastoma	medulloblastoma	NOUN
fnp-8974	548	16	.	.	PUNCT
fnp-8974	549	1	therefore	therefore	ADV
fnp-8974	549	2	,	,	PUNCT
fnp-8974	549	3	we	we	PRON
fnp-8974	549	4	are	be	AUX
fnp-8974	549	5	aiming	aim	VERB
fnp-8974	549	6	to	to	PART
fnp-8974	549	7	develop	develop	VERB
fnp-8974	549	8	a	a	DET
fnp-8974	549	9	targeting	targeting	NOUN
fnp-8974	549	10	strategy	strategy	NOUN
fnp-8974	549	11	against	against	ADP
fnp-8974	549	12	4ebp1	4ebp1	PRON
fnp-8974	549	13	to	to	PART
fnp-8974	549	14	drive	drive	VERB
fnp-8974	549	15	cancer	cancer	NOUN
fnp-8974	549	16	cells	cell	NOUN
fnp-8974	549	17	to	to	ADP
fnp-8974	549	18	death	death	NOUN
fnp-8974	549	19	under	under	ADP
fnp-8974	549	20	metabolic	metabolic	NOUN
fnp-8974	549	21	stress	stress	NOUN
fnp-8974	549	22	.	.	PUNCT
fnp-8974	550	1	using	use	VERB
fnp-8974	550	2	an	an	DET
fnp-8974	550	3	in	in	ADP
fnp-8974	550	4	-	-	PUNCT
fnp-8974	550	5	silico	silico	NOUN
fnp-8974	550	6	screening	screen	VERB
fnp-8974	550	7	approach	approach	NOUN
fnp-8974	550	8	we	we	PRON
fnp-8974	550	9	identified	identify	VERB
fnp-8974	550	10	potential	potential	ADJ
fnp-8974	550	11	inhibitors	inhibitor	NOUN
fnp-8974	550	12	of	of	ADP
fnp-8974	550	13	4ebp1	4ebp1	NUM
fnp-8974	550	14	,	,	PUNCT
fnp-8974	550	15	predicted	predict	VERB
fnp-8974	550	16	by	by	ADP
fnp-8974	550	17	molecular	molecular	ADJ
fnp-8974	550	18	docking	docking	NOUN
fnp-8974	550	19	to	to	PART
fnp-8974	550	20	disrupt	disrupt	VERB
fnp-8974	550	21	the	the	DET
fnp-8974	550	22	4ebp1	4ebp1	NUM
fnp-8974	550	23	-	-	PUNCT
fnp-8974	550	24	eif4e	eif4e	NOUN
fnp-8974	550	25	interaction	interaction	NOUN
fnp-8974	550	26	.	.	PUNCT
fnp-8974	551	1	using	use	VERB
fnp-8974	551	2	in	in	ADP
fnp-8974	551	3	vitro	vitro	X
fnp-8974	551	4	binding	bind	VERB
fnp-8974	551	5	assays	assay	NOUN
fnp-8974	551	6	and	and	CCONJ
fnp-8974	551	7	cellular	cellular	ADJ
fnp-8974	551	8	assays	assay	NOUN
fnp-8974	551	9	,	,	PUNCT
fnp-8974	551	10	these	these	DET
fnp-8974	551	11	compound	compound	NOUN
fnp-8974	551	12	candidates	candidate	NOUN
fnp-8974	551	13	are	be	AUX
fnp-8974	551	14	being	be	AUX
fnp-8974	551	15	validated	validate	VERB
fnp-8974	551	16	for	for	ADP
fnp-8974	551	17	their	their	PRON
fnp-8974	551	18	ability	ability	NOUN
fnp-8974	551	19	to	to	PART
fnp-8974	551	20	block	block	VERB
fnp-8974	551	21	the	the	DET
fnp-8974	551	22	physical	physical	ADJ
fnp-8974	551	23	binding	binding	NOUN
fnp-8974	551	24	of	of	ADP
fnp-8974	551	25	4ebp1	4ebp1	PRON
fnp-8974	551	26	to	to	ADP
fnp-8974	551	27	eif4e	eif4e	VERB
fnp-8974	551	28	,	,	PUNCT
fnp-8974	551	29	to	to	PART
fnp-8974	551	30	induce	induce	VERB
fnp-8974	551	31	cell	cell	NOUN
fnp-8974	551	32	death	death	NOUN
fnp-8974	551	33	under	under	ADP
fnp-8974	551	34	glucose	glucose	NOUN
fnp-8974	551	35	deprivation	deprivation	NOUN
fnp-8974	551	36	and	and	CCONJ
fnp-8974	551	37	to	to	PART
fnp-8974	551	38	reduce	reduce	VERB
fnp-8974	551	39	tumorigenic	tumorigenic	ADJ
fnp-8974	551	40	potential	potential	NOUN
fnp-8974	551	41	.	.	PUNCT
fnp-8974	552	1	our	our	PRON
fnp-8974	552	2	strategy	strategy	NOUN
fnp-8974	552	3	to	to	PART
fnp-8974	552	4	target	target	VERB
fnp-8974	552	5	4ebp1	4ebp1	PRON
fnp-8974	552	6	may	may	AUX
fnp-8974	552	7	represent	represent	VERB
fnp-8974	552	8	a	a	DET
fnp-8974	552	9	novel	novel	ADJ
fnp-8974	552	10	therapeutic	therapeutic	ADJ
fnp-8974	552	11	approach	approach	NOUN
fnp-8974	552	12	to	to	PART
fnp-8974	552	13	treat	treat	VERB
fnp-8974	552	14	,	,	PUNCT
fnp-8974	552	15	yet	yet	ADV
fnp-8974	552	16	,	,	PUNCT
fnp-8974	552	17	incurable	incurable	ADJ
fnp-8974	552	18	malignant	malignant	ADJ
fnp-8974	552	19	brain	brain	NOUN
fnp-8974	552	20	tumors	tumor	NOUN
fnp-8974	552	21	.	.	PUNCT
fnp-8974	553	1	p43	p43	PROPN
fnp-8974	553	2	free	free	ADJ
fnp-8974	553	3	neuropathol	neuropathol	NOUN
fnp-8974	553	4	6:17:64	6:17:64	NUM
fnp-8974	553	5	mechanisms	mechanism	NOUN
fnp-8974	553	6	of	of	ADP
fnp-8974	553	7	transformation	transformation	NOUN
fnp-8974	553	8	from	from	ADP
fnp-8974	553	9	subependymoma	subependymoma	NOUN
fnp-8974	553	10	to	to	PART
fnp-8974	553	11	ependymoma	ependymoma	VERB
fnp-8974	553	12	hannah	hannah	PROPN
fnp-8974	553	13	jessner1,2	jessner1,2	PROPN
fnp-8974	553	14	,	,	PUNCT
fnp-8974	553	15	flavia	flavia	PROPN
fnp-8974	553	16	watusi	watusi	PROPN
fnp-8974	553	17	de	de	X
fnp-8974	553	18	faria1	faria1	PROPN
fnp-8974	553	19	,	,	PUNCT
fnp-8974	553	20	clara	clara	PROPN
fnp-8974	553	21	inserte	inserte	PROPN
fnp-8974	553	22	singla3	singla3	PROPN
fnp-8974	553	23	,	,	PUNCT
fnp-8974	553	24	thomas	thomas	PROPN
fnp-8974	553	25	albert1	albert1	PROPN
fnp-8974	553	26	,	,	PUNCT
fnp-8974	553	27	ina	ina	PROPN
fnp-8974	553	28	lu1	lu1	PROPN
fnp-8974	553	29	,	,	PUNCT
fnp-8974	553	30	claudia	claudia	PROPN
fnp-8974	553	31	rossig1	rossig1	PROPN
fnp-8974	553	32	,	,	PUNCT
fnp-8974	553	33	ulrich	ulrich	PROPN
fnp-8974	553	34	schüller4	schüller4	PROPN
fnp-8974	553	35	,	,	PUNCT
fnp-8974	553	36	erik	erik	PROPN
fnp-8974	553	37	schüftan1	schüftan1	PROPN
fnp-8974	553	38	,	,	PUNCT
fnp-8974	553	39	simon	simon	PROPN
fnp-8974	553	40	johann	johann	PROPN
fnp-8974	553	41	kaufmann1	kaufmann1	PROPN
fnp-8974	553	42	,	,	PUNCT
fnp-8974	553	43	angela	angela	PROPN
fnp-8974	553	44	brentrup5	brentrup5	PROPN
fnp-8974	553	45	,	,	PUNCT
fnp-8974	553	46	ann	ann	PROPN
fnp-8974	553	47	-	-	PUNCT
fnp-8974	553	48	katrin	katrin	PROPN
fnp-8974	553	49	bruns5	bruns5	PROPN
fnp-8974	553	50	,	,	PUNCT
fnp-8974	553	51	dorothee	dorothee	PROPN
fnp-8974	553	52	cäcilia	cäcilia	PROPN
fnp-8974	553	53	spille5	spille5	PROPN
fnp-8974	553	54	,	,	PUNCT
fnp-8974	553	55	christian	christian	PROPN
fnp-8974	553	56	thomas2	thomas2	PROPN
fnp-8974	553	57	,	,	PUNCT
fnp-8974	553	58	kornelius	kornelius	ADJ
fnp-8974	553	59	kerl1	kerl1	NOUN
fnp-8974	553	60	1	1	NUM
fnp-8974	553	61	department	department	NOUN
fnp-8974	553	62	of	of	ADP
fnp-8974	553	63	pediatric	pediatric	ADJ
fnp-8974	553	64	hematology	hematology	NOUN
fnp-8974	553	65	and	and	CCONJ
fnp-8974	553	66	oncology	oncology	NOUN
fnp-8974	553	67	,	,	PUNCT
fnp-8974	553	68	university	university	NOUN
fnp-8974	553	69	children	child	NOUN
fnp-8974	553	70	’s	’s	PART
fnp-8974	553	71	hospital	hospital	NOUN
fnp-8974	553	72	münster	münster	NOUN
fnp-8974	553	73	,	,	PUNCT
fnp-8974	553	74	münster	münster	PROPN
fnp-8974	553	75	,	,	PUNCT
fnp-8974	553	76	germany	germany	PROPN
fnp-8974	553	77	2	2	NUM
fnp-8974	553	78	institute	institute	PROPN
fnp-8974	553	79	of	of	ADP
fnp-8974	553	80	neuropathology	neuropathology	NOUN
fnp-8974	553	81	,	,	PUNCT
fnp-8974	553	82	university	university	NOUN
fnp-8974	553	83	hospital	hospital	NOUN
fnp-8974	553	84	münster	münster	NOUN
fnp-8974	553	85	,	,	PUNCT
fnp-8974	553	86	münster	münster	PROPN
fnp-8974	553	87	,	,	PUNCT
fnp-8974	553	88	germany	germany	PROPN
fnp-8974	553	89	3	3	NUM
fnp-8974	553	90	institute	institute	PROPN
fnp-8974	553	91	of	of	ADP
fnp-8974	553	92	medical	medical	ADJ
fnp-8974	553	93	informatics	informatics	PROPN
fnp-8974	553	94	,	,	PUNCT
fnp-8974	553	95	university	university	NOUN
fnp-8974	553	96	of	of	ADP
fnp-8974	553	97	münster	münster	NOUN
fnp-8974	553	98	,	,	PUNCT
fnp-8974	553	99	münster	münster	PROPN
fnp-8974	553	100	,	,	PUNCT
fnp-8974	553	101	germany	germany	PROPN
fnp-8974	553	102	4	4	NUM
fnp-8974	553	103	institute	institute	PROPN
fnp-8974	553	104	of	of	ADP
fnp-8974	553	105	neuropathology	neuropathology	NOUN
fnp-8974	553	106	,	,	PUNCT
fnp-8974	553	107	university	university	NOUN
fnp-8974	553	108	medical	medical	ADJ
fnp-8974	553	109	center	center	PROPN
fnp-8974	553	110	hamburg	hamburg	PROPN
fnp-8974	553	111	-	-	PUNCT
fnp-8974	553	112	eppendorf	eppendorf	PROPN
fnp-8974	553	113	,	,	PUNCT
fnp-8974	553	114	hamburg	hamburg	PROPN
fnp-8974	553	115	,	,	PUNCT
fnp-8974	553	116	germany	germany	PROPN
fnp-8974	553	117	5	5	NUM
fnp-8974	553	118	department	department	NOUN
fnp-8974	553	119	of	of	ADP
fnp-8974	553	120	neurosurgery	neurosurgery	NOUN
fnp-8974	553	121	,	,	PUNCT
fnp-8974	553	122	university	university	NOUN
fnp-8974	553	123	hospital	hospital	NOUN
fnp-8974	553	124	münster	münster	NOUN
fnp-8974	553	125	,	,	PUNCT
fnp-8974	553	126	münster	münster	PROPN
fnp-8974	553	127	,	,	PUNCT
fnp-8974	553	128	germany	germany	PROPN
fnp-8974	553	129	background	background	NOUN
fnp-8974	553	130	:	:	PUNCT
fnp-8974	553	131	subependymomas	subependymomas	PROPN
fnp-8974	553	132	(	(	PUNCT
fnp-8974	553	133	ses	ses	PROPN
fnp-8974	553	134	)	)	PUNCT
fnp-8974	553	135	are	be	AUX
fnp-8974	553	136	slow	slow	ADV
fnp-8974	553	137	-	-	PUNCT
fnp-8974	553	138	growing	grow	VERB
fnp-8974	553	139	central	central	ADJ
fnp-8974	553	140	nervous	nervous	ADJ
fnp-8974	553	141	system	system	NOUN
fnp-8974	553	142	tumors	tumor	NOUN
fnp-8974	553	143	,	,	PUNCT
fnp-8974	553	144	yet	yet	CCONJ
fnp-8974	553	145	those	those	PRON
fnp-8974	553	146	in	in	ADP
fnp-8974	553	147	the	the	DET
fnp-8974	553	148	posterior	posterior	ADJ
fnp-8974	553	149	fossa	fossa	NOUN
fnp-8974	553	150	(	(	PUNCT
fnp-8974	553	151	pf	pf	NOUN
fnp-8974	553	152	-	-	PUNCT
fnp-8974	553	153	ses	se	NOUN
fnp-8974	553	154	)	)	PUNCT
fnp-8974	553	155	can	can	AUX
fnp-8974	553	156	behave	behave	VERB
fnp-8974	553	157	more	more	ADV
fnp-8974	553	158	aggressively	aggressively	ADV
fnp-8974	553	159	,	,	PUNCT
fnp-8974	553	160	often	often	ADV
fnp-8974	553	161	showing	show	VERB
fnp-8974	553	162	areas	area	NOUN
fnp-8974	553	163	of	of	ADP
fnp-8974	553	164	higher	high	ADJ
fnp-8974	553	165	-	-	PUNCT
fnp-8974	553	166	grade	grade	NOUN
fnp-8974	553	167	ependymal	ependymal	ADJ
fnp-8974	553	168	differentiation	differentiation	NOUN
fnp-8974	553	169	.	.	PUNCT
fnp-8974	554	1	recent	recent	ADJ
fnp-8974	554	2	studies	study	NOUN
fnp-8974	554	3	suggest	suggest	VERB
fnp-8974	554	4	that	that	SCONJ
fnp-8974	554	5	chromosome	chromosome	NOUN
fnp-8974	554	6	6	6	NUM
fnp-8974	554	7	loss	loss	NOUN
fnp-8974	554	8	and	and	CCONJ
fnp-8974	554	9	tert	tert	NOUN
fnp-8974	554	10	promoter	promoter	NOUN
fnp-8974	554	11	mutations	mutation	NOUN
fnp-8974	554	12	are	be	AUX
fnp-8974	554	13	associated	associate	VERB
fnp-8974	554	14	with	with	ADP
fnp-8974	554	15	this	this	DET
fnp-8974	554	16	transition	transition	NOUN
fnp-8974	554	17	,	,	PUNCT
fnp-8974	554	18	supporting	support	VERB
fnp-8974	554	19	a	a	DET
fnp-8974	554	20	model	model	NOUN
fnp-8974	554	21	of	of	ADP
fnp-8974	554	22	progression	progression	NOUN
fnp-8974	554	23	from	from	ADP
fnp-8974	554	24	low	low	ADJ
fnp-8974	554	25	-	-	PUNCT
fnp-8974	554	26	grade	grade	NOUN
fnp-8974	554	27	to	to	ADP
fnp-8974	554	28	more	more	ADV
fnp-8974	554	29	malignant	malignant	ADJ
fnp-8974	554	30	phenotypes	phenotype	NOUN
fnp-8974	554	31	.	.	PUNCT
fnp-8974	555	1	this	this	DET
fnp-8974	555	2	study	study	NOUN
fnp-8974	555	3	investigates	investigate	VERB
fnp-8974	555	4	the	the	DET
fnp-8974	555	5	molecular	molecular	ADJ
fnp-8974	555	6	and	and	CCONJ
fnp-8974	555	7	spatial	spatial	ADJ
fnp-8974	555	8	heterogeneity	heterogeneity	NOUN
fnp-8974	555	9	underlying	underlie	VERB
fnp-8974	555	10	this	this	DET
fnp-8974	555	11	evolution	evolution	NOUN
fnp-8974	555	12	.	.	PUNCT
fnp-8974	556	1	methods	method	NOUN
fnp-8974	556	2	:	:	PUNCT
fnp-8974	556	3	we	we	PRON
fnp-8974	556	4	analyzed	analyze	VERB
fnp-8974	556	5	27	27	NUM
fnp-8974	556	6	pf	pf	NOUN
fnp-8974	556	7	-	-	PUNCT
fnp-8974	556	8	se	se	NOUN
fnp-8974	556	9	samples	sample	NOUN
fnp-8974	556	10	from	from	ADP
fnp-8974	556	11	25	25	NUM
fnp-8974	556	12	patients	patient	NOUN
fnp-8974	556	13	,	,	PUNCT
fnp-8974	556	14	alongside	alongside	ADP
fnp-8974	556	15	5	5	NUM
fnp-8974	556	16	pf	pf	NOUN
fnp-8974	556	17	-	-	PUNCT
fnp-8974	556	18	a	a	NOUN
fnp-8974	556	19	and	and	CCONJ
fnp-8974	556	20	6	6	NUM
fnp-8974	556	21	pf	pf	PROPN
fnp-8974	556	22	-	-	PUNCT
fnp-8974	556	23	b	b	NOUN
fnp-8974	556	24	ependymomas	ependymoma	NOUN
fnp-8974	556	25	.	.	PUNCT
fnp-8974	557	1	using	use	VERB
fnp-8974	557	2	single	single	ADJ
fnp-8974	557	3	-	-	PUNCT
fnp-8974	557	4	nucleus	nucleus	NOUN
fnp-8974	557	5	rna	rna	NOUN
fnp-8974	557	6	sequencing	sequencing	NOUN
fnp-8974	557	7	,	,	PUNCT
fnp-8974	557	8	spatial	spatial	ADJ
fnp-8974	557	9	transcriptomics	transcriptomic	NOUN
fnp-8974	557	10	,	,	PUNCT
fnp-8974	557	11	and	and	CCONJ
fnp-8974	557	12	bulk	bulk	ADJ
fnp-8974	557	13	rna	rna	NOUN
fnp-8974	557	14	sequencing	sequencing	NOUN
fnp-8974	557	15	,	,	PUNCT
fnp-8974	557	16	we	we	PRON
fnp-8974	557	17	assessed	assess	VERB
fnp-8974	557	18	transcriptional	transcriptional	NOUN
fnp-8974	557	19	and	and	CCONJ
fnp-8974	557	20	spatial	spatial	ADJ
fnp-8974	557	21	dynamics	dynamic	NOUN
fnp-8974	557	22	.	.	PUNCT
fnp-8974	558	1	hypoxia	hypoxia	NOUN
fnp-8974	558	2	-	-	PUNCT
fnp-8974	558	3	inducible	inducible	ADJ
fnp-8974	558	4	factor	factor	NOUN
fnp-8974	558	5	1	1	NUM
fnp-8974	558	6	-	-	PUNCT
fnp-8974	558	7	alpha	alpha	NOUN
fnp-8974	558	8	(	(	PUNCT
fnp-8974	558	9	hif1a	hif1a	PROPN
fnp-8974	558	10	)	)	PUNCT
fnp-8974	558	11	immunohistochemistry	immunohistochemistry	NOUN
fnp-8974	558	12	was	be	AUX
fnp-8974	558	13	also	also	ADV
fnp-8974	558	14	performed	perform	VERB
fnp-8974	558	15	.	.	PUNCT
fnp-8974	559	1	results	result	NOUN
fnp-8974	559	2	:	:	PUNCT
fnp-8974	559	3	a	a	DET
fnp-8974	559	4	hypoxia	hypoxia	NOUN
fnp-8974	559	5	-	-	PUNCT
fnp-8974	559	6	associated	associate	VERB
fnp-8974	559	7	transcriptional	transcriptional	NOUN
fnp-8974	559	8	program	program	NOUN
fnp-8974	559	9	was	be	AUX
fnp-8974	559	10	enriched	enrich	VERB
fnp-8974	559	11	in	in	ADP
fnp-8974	559	12	ependymal	ependymal	ADJ
fnp-8974	559	13	-	-	PUNCT
fnp-8974	559	14	like	like	ADJ
fnp-8974	559	15	regions	region	NOUN
fnp-8974	559	16	of	of	ADP
fnp-8974	559	17	pf	pf	NOUN
fnp-8974	559	18	-	-	PUNCT
fnp-8974	559	19	ses	ses	PROPN
fnp-8974	559	20	.	.	PUNCT
fnp-8974	560	1	copy	copy	NOUN
fnp-8974	560	2	number	number	NOUN
fnp-8974	560	3	analysis	analysis	NOUN
fnp-8974	560	4	revealed	reveal	VERB
fnp-8974	560	5	increasing	increase	VERB
fnp-8974	560	6	chromosome	chromosome	NOUN
fnp-8974	560	7	6	6	NUM
fnp-8974	560	8	loss	loss	NOUN
fnp-8974	560	9	correlating	correlate	VERB
fnp-8974	560	10	with	with	ADP
fnp-8974	560	11	ependymal	ependymal	ADJ
fnp-8974	560	12	differentiation	differentiation	NOUN
fnp-8974	560	13	and	and	CCONJ
fnp-8974	560	14	hypoxia	hypoxia	NOUN
fnp-8974	560	15	-	-	PUNCT
fnp-8974	560	16	related	relate	VERB
fnp-8974	560	17	gene	gene	NOUN
fnp-8974	560	18	expression	expression	NOUN
fnp-8974	560	19	.	.	PUNCT
fnp-8974	561	1	tumors	tumor	NOUN
fnp-8974	561	2	with	with	ADP
fnp-8974	561	3	both	both	CCONJ
fnp-8974	561	4	subependymal	subependymal	ADJ
fnp-8974	561	5	and	and	CCONJ
fnp-8974	561	6	ependymal	ependymal	ADJ
fnp-8974	561	7	areas	area	NOUN
fnp-8974	561	8	exhibited	exhibit	VERB
fnp-8974	561	9	a	a	DET
fnp-8974	561	10	reactive	reactive	ADJ
fnp-8974	561	11	transcriptional	transcriptional	NOUN
fnp-8974	561	12	state	state	NOUN
fnp-8974	561	13	marked	mark	VERB
fnp-8974	561	14	by	by	ADP
fnp-8974	561	15	stress	stress	NOUN
fnp-8974	561	16	and	and	CCONJ
fnp-8974	561	17	interferon	interferon	ADJ
fnp-8974	561	18	signaling	signaling	NOUN
fnp-8974	561	19	,	,	PUNCT
fnp-8974	561	20	suggesting	suggest	VERB
fnp-8974	561	21	an	an	DET
fnp-8974	561	22	active	active	ADJ
fnp-8974	561	23	transitional	transitional	ADJ
fnp-8974	561	24	phase	phase	NOUN
fnp-8974	561	25	.	.	PUNCT
fnp-8974	562	1	immune	immune	ADJ
fnp-8974	562	2	profiling	profiling	NOUN
fnp-8974	562	3	showed	show	VERB
fnp-8974	562	4	a	a	DET
fnp-8974	562	5	shift	shift	NOUN
fnp-8974	562	6	from	from	ADP
fnp-8974	562	7	pro	pro	ADJ
fnp-8974	562	8	-	-	ADJ
fnp-8974	562	9	inflammatory	inflammatory	ADJ
fnp-8974	562	10	to	to	ADP
fnp-8974	562	11	immunosuppressive	immunosuppressive	ADJ
fnp-8974	562	12	signatures	signature	NOUN
fnp-8974	562	13	along	along	ADP
fnp-8974	562	14	the	the	DET
fnp-8974	562	15	histologic	histologic	ADJ
fnp-8974	562	16	spectrum	spectrum	NOUN
fnp-8974	562	17	,	,	PUNCT
fnp-8974	562	18	indicating	indicate	VERB
fnp-8974	562	19	progressive	progressive	ADJ
fnp-8974	562	20	immune	immune	ADJ
fnp-8974	562	21	evasion	evasion	NOUN
fnp-8974	562	22	.	.	PUNCT
fnp-8974	563	1	conclusion	conclusion	NOUN
fnp-8974	563	2	:	:	PUNCT
fnp-8974	563	3	these	these	DET
fnp-8974	563	4	findings	finding	NOUN
fnp-8974	563	5	highlight	highlight	VERB
fnp-8974	563	6	hypoxia	hypoxia	NOUN
fnp-8974	563	7	and	and	CCONJ
fnp-8974	563	8	chromosome	chromosome	NOUN
fnp-8974	563	9	6	6	NUM
fnp-8974	563	10	loss	loss	NOUN
fnp-8974	563	11	as	as	ADP
fnp-8974	563	12	interconnected	interconnected	ADJ
fnp-8974	563	13	mechanisms	mechanism	NOUN
fnp-8974	563	14	driving	drive	VERB
fnp-8974	563	15	malignant	malignant	ADJ
fnp-8974	563	16	transformation	transformation	NOUN
fnp-8974	563	17	in	in	ADP
fnp-8974	563	18	pf	pf	NOUN
fnp-8974	563	19	-	-	PUNCT
fnp-8974	563	20	ses	ses	NOUN
fnp-8974	563	21	.	.	PUNCT
fnp-8974	564	1	the	the	DET
fnp-8974	564	2	parallels	parallel	NOUN
fnp-8974	564	3	with	with	ADP
fnp-8974	564	4	aggressive	aggressive	ADJ
fnp-8974	564	5	pf	pf	NOUN
fnp-8974	564	6	-	-	PUNCT
fnp-8974	564	7	as	as	SCONJ
fnp-8974	564	8	suggest	suggest	NOUN
fnp-8974	564	9	shared	share	VERB
fnp-8974	564	10	evolutionary	evolutionary	ADJ
fnp-8974	564	11	pathways	pathway	NOUN
fnp-8974	564	12	among	among	ADP
fnp-8974	564	13	posterior	posterior	ADJ
fnp-8974	564	14	fossa	fossa	ADJ
fnp-8974	564	15	ependymal	ependymal	ADJ
fnp-8974	564	16	tumors	tumor	NOUN
fnp-8974	564	17	.	.	PUNCT
fnp-8974	565	1	p44	p44	NOUN
fnp-8974	565	2	free	free	ADJ
fnp-8974	565	3	neuropathol	neuropathol	NOUN
fnp-8974	565	4	6:17:65	6:17:65	NUM
fnp-8974	565	5	leveraging	leverage	VERB
fnp-8974	565	6	off	off	ADP
fnp-8974	565	7	-	-	PUNCT
fnp-8974	565	8	target	target	NOUN
fnp-8974	565	9	reads	read	NOUN
fnp-8974	565	10	for	for	ADP
fnp-8974	565	11	genome	genome	NOUN
fnp-8974	565	12	-	-	PUNCT
fnp-8974	565	13	wide	wide	ADJ
fnp-8974	565	14	copy	copy	NOUN
fnp-8974	565	15	number	number	NOUN
fnp-8974	565	16	profiling	profiling	NOUN
fnp-8974	565	17	in	in	ADP
fnp-8974	565	18	ngs	ng	NOUN
fnp-8974	565	19	panels	panel	NOUN
fnp-8974	565	20	jan	jan	PROPN
fnp-8974	565	21	schnorrenberg1	schnorrenberg1	PROPN
fnp-8974	565	22	,	,	PUNCT
fnp-8974	565	23	yannis	yannis	PROPN
fnp-8974	565	24	adrian1	adrian1	PROPN
fnp-8974	565	25	,	,	PUNCT
fnp-8974	565	26	werner	werner	PROPN
fnp-8974	565	27	paulus1	paulus1	PROPN
fnp-8974	565	28	,	,	PUNCT
fnp-8974	565	29	martin	martin	PROPN
fnp-8974	565	30	hasselblatt1	hasselblatt1	PROPN
fnp-8974	565	31	,	,	PUNCT
fnp-8974	565	32	christian	christian	PROPN
fnp-8974	565	33	thomas1	thomas1	NOUN
fnp-8974	565	34	1	1	NUM
fnp-8974	565	35	institut	institut	PROPN
fnp-8974	565	36	für	für	PROPN
fnp-8974	565	37	neuropathologie	neuropathologie	PROPN
fnp-8974	565	38	münster	münster	PROPN
fnp-8974	565	39	,	,	PUNCT
fnp-8974	565	40	münster	münster	PROPN
fnp-8974	565	41	,	,	PUNCT
fnp-8974	565	42	germany	germany	PROPN
fnp-8974	565	43	background	background	NOUN
fnp-8974	565	44	:	:	PUNCT
fnp-8974	565	45	copy	copy	VERB
fnp-8974	565	46	number	number	NOUN
fnp-8974	565	47	variations	variation	NOUN
fnp-8974	565	48	(	(	PUNCT
fnp-8974	565	49	cnvs	cnvs	NOUN
fnp-8974	565	50	)	)	PUNCT
fnp-8974	565	51	are	be	AUX
fnp-8974	565	52	crucial	crucial	ADJ
fnp-8974	565	53	for	for	ADP
fnp-8974	565	54	the	the	DET
fnp-8974	565	55	diagnosis	diagnosis	NOUN
fnp-8974	565	56	and	and	CCONJ
fnp-8974	565	57	prognosis	prognosis	NOUN
fnp-8974	565	58	of	of	ADP
fnp-8974	565	59	central	central	ADJ
fnp-8974	565	60	nervous	nervous	ADJ
fnp-8974	565	61	system	system	NOUN
fnp-8974	565	62	(	(	PUNCT
fnp-8974	565	63	cns	cns	NOUN
fnp-8974	565	64	)	)	PUNCT
fnp-8974	565	65	tumors	tumor	NOUN
fnp-8974	565	66	.	.	PUNCT
fnp-8974	566	1	although	although	SCONJ
fnp-8974	566	2	typically	typically	ADV
fnp-8974	566	3	assessed	assess	VERB
fnp-8974	566	4	using	use	VERB
fnp-8974	566	5	chromosomal	chromosomal	ADJ
fnp-8974	566	6	or	or	CCONJ
fnp-8974	566	7	dna	dna	PROPN
fnp-8974	566	8	methylation	methylation	NOUN
fnp-8974	566	9	microarrays	microarray	NOUN
fnp-8974	566	10	,	,	PUNCT
fnp-8974	566	11	cnv	cnv	PROPN
fnp-8974	566	12	data	datum	NOUN
fnp-8974	566	13	can	can	AUX
fnp-8974	566	14	also	also	ADV
fnp-8974	566	15	be	be	AUX
fnp-8974	566	16	extracted	extract	VERB
fnp-8974	566	17	from	from	ADP
fnp-8974	566	18	next	next	ADJ
fnp-8974	566	19	-	-	PUNCT
fnp-8974	566	20	generation	generation	NOUN
fnp-8974	566	21	sequencing	sequencing	NOUN
fnp-8974	566	22	(	(	PUNCT
fnp-8974	566	23	ngs	ng	NOUN
fnp-8974	566	24	)	)	PUNCT
fnp-8974	566	25	panels	panel	NOUN
fnp-8974	566	26	.	.	PUNCT
fnp-8974	567	1	off	off	ADP
fnp-8974	567	2	-	-	PUNCT
fnp-8974	567	3	target	target	NOUN
fnp-8974	567	4	reads	read	VERB
fnp-8974	567	5	mapping	mapping	NOUN
fnp-8974	567	6	outside	outside	ADP
fnp-8974	567	7	the	the	DET
fnp-8974	567	8	targeted	target	VERB
fnp-8974	567	9	regions	region	NOUN
fnp-8974	567	10	are	be	AUX
fnp-8974	567	11	usually	usually	ADV
fnp-8974	567	12	discarded	discard	VERB
fnp-8974	567	13	in	in	ADP
fnp-8974	567	14	standard	standard	ADJ
fnp-8974	567	15	ngs	ng	NOUN
fnp-8974	567	16	workflows	workflow	NOUN
fnp-8974	567	17	.	.	PUNCT
fnp-8974	568	1	objectives	objective	NOUN
fnp-8974	568	2	:	:	PUNCT
fnp-8974	568	3	our	our	PRON
fnp-8974	568	4	study	study	NOUN
fnp-8974	568	5	evaluates	evaluate	VERB
fnp-8974	568	6	whether	whether	SCONJ
fnp-8974	568	7	these	these	DET
fnp-8974	568	8	reads	read	NOUN
fnp-8974	568	9	can	can	AUX
fnp-8974	568	10	be	be	AUX
fnp-8974	568	11	repurposed	repurpose	VERB
fnp-8974	568	12	for	for	ADP
fnp-8974	568	13	genome	genome	NOUN
fnp-8974	568	14	-	-	PUNCT
fnp-8974	568	15	wide	wide	ADJ
fnp-8974	568	16	cnv	cnv	NOUN
fnp-8974	568	17	profiling	profiling	NOUN
fnp-8974	568	18	in	in	ADP
fnp-8974	568	19	cns	cns	PROPN
fnp-8974	568	20	tumors	tumor	NOUN
fnp-8974	568	21	using	use	VERB
fnp-8974	568	22	a	a	DET
fnp-8974	568	23	small	small	ADJ
fnp-8974	568	24	,	,	PUNCT
fnp-8974	568	25	custom	custom	NOUN
fnp-8974	568	26	ngs	ng	NOUN
fnp-8974	568	27	panel	panel	NOUN
fnp-8974	568	28	not	not	PART
fnp-8974	568	29	specifically	specifically	ADV
fnp-8974	568	30	designed	design	VERB
fnp-8974	568	31	for	for	ADP
fnp-8974	568	32	cnv	cnv	NOUN
fnp-8974	568	33	analysis	analysis	NOUN
fnp-8974	568	34	.	.	PUNCT
fnp-8974	569	1	methods	method	NOUN
fnp-8974	569	2	:	:	PUNCT
fnp-8974	569	3	we	we	PRON
fnp-8974	569	4	analyzed	analyze	VERB
fnp-8974	569	5	60	60	NUM
fnp-8974	569	6	cns	cns	NOUN
fnp-8974	569	7	tumors	tumor	NOUN
fnp-8974	569	8	,	,	PUNCT
fnp-8974	569	9	including	include	VERB
fnp-8974	569	10	idh	idh	NOUN
fnp-8974	569	11	-	-	PUNCT
fnp-8974	569	12	wildtype	wildtype	NOUN
fnp-8974	569	13	glioblastomas	glioblastoma	NOUN
fnp-8974	569	14	(	(	PUNCT
fnp-8974	569	15	n	n	CCONJ
fnp-8974	569	16	 	 	SPACE
fnp-8974	569	17	=	=	NOUN
fnp-8974	569	18	 	 	SPACE
fnp-8974	569	19	25	25	NUM
fnp-8974	569	20	)	)	PUNCT
fnp-8974	569	21	,	,	PUNCT
fnp-8974	569	22	oligodendrogliomas	oligodendroglioma	NOUN
fnp-8974	569	23	(	(	PUNCT
fnp-8974	569	24	n	n	CCONJ
fnp-8974	569	25	 	 	SPACE
fnp-8974	569	26	=	=	NOUN
fnp-8974	569	27	 	 	SPACE
fnp-8974	569	28	15	15	NUM
fnp-8974	569	29	)	)	PUNCT
fnp-8974	569	30	,	,	PUNCT
fnp-8974	569	31	ependymomas	ependymomas	PROPN
fnp-8974	569	32	(	(	PUNCT
fnp-8974	569	33	n	n	CCONJ
fnp-8974	569	34	 	 	SPACE
fnp-8974	569	35	=	=	NOUN
fnp-8974	569	36	 	 	SPACE
fnp-8974	569	37	9	9	NUM
fnp-8974	569	38	)	)	PUNCT
fnp-8974	569	39	,	,	PUNCT
fnp-8974	569	40	medulloblastomas	medulloblastoma	NOUN
fnp-8974	569	41	(	(	PUNCT
fnp-8974	569	42	n	n	CCONJ
fnp-8974	569	43	 	 	SPACE
fnp-8974	569	44	=	=	NOUN
fnp-8974	569	45	 	 	SPACE
fnp-8974	569	46	6	6	NUM
fnp-8974	569	47	)	)	PUNCT
fnp-8974	569	48	,	,	PUNCT
fnp-8974	569	49	and	and	CCONJ
fnp-8974	569	50	choroid	choroid	NOUN
fnp-8974	569	51	plexus	plexus	NOUN
fnp-8974	569	52	tumors	tumor	NOUN
fnp-8974	569	53	(	(	PUNCT
fnp-8974	569	54	n	n	CCONJ
fnp-8974	569	55	 	 	SPACE
fnp-8974	569	56	=	=	NOUN
fnp-8974	569	57	 	 	SPACE
fnp-8974	569	58	5	5	NUM
fnp-8974	569	59	)	)	PUNCT
fnp-8974	569	60	.	.	PUNCT
fnp-8974	570	1	each	each	DET
fnp-8974	570	2	case	case	NOUN
fnp-8974	570	3	underwent	undergo	VERB
fnp-8974	570	4	epic	epic	ADJ
fnp-8974	570	5	methylation	methylation	NOUN
fnp-8974	570	6	profiling	profiling	NOUN
fnp-8974	570	7	and	and	CCONJ
fnp-8974	570	8	hybrid	hybrid	NOUN
fnp-8974	570	9	-	-	PUNCT
fnp-8974	570	10	capture	capture	NOUN
fnp-8974	570	11	ngs	ngs	PROPN
fnp-8974	570	12	panel	panel	NOUN
fnp-8974	570	13	(	(	PUNCT
fnp-8974	570	14	31	31	NUM
fnp-8974	570	15	genes	gene	NOUN
fnp-8974	570	16	,	,	PUNCT
fnp-8974	570	17	0.17	0.17	NUM
fnp-8974	570	18	 	 	SPACE
fnp-8974	570	19	mb	mb	NOUN
fnp-8974	570	20	)	)	PUNCT
fnp-8974	570	21	.	.	PUNCT
fnp-8974	571	1	cnv	cnv	PROPN
fnp-8974	571	2	profiles	profile	NOUN
fnp-8974	571	3	were	be	AUX
fnp-8974	571	4	generated	generate	VERB
fnp-8974	571	5	using	use	VERB
fnp-8974	571	6	cnvkit	cnvkit	PROPN
fnp-8974	571	7	and	and	CCONJ
fnp-8974	571	8	custom	custom	NOUN
fnp-8974	571	9	python	python	NOUN
fnp-8974	571	10	scripts	script	NOUN
fnp-8974	571	11	.	.	PUNCT
fnp-8974	572	1	results	result	NOUN
fnp-8974	572	2	:	:	PUNCT
fnp-8974	572	3	sequencing	sequence	VERB
fnp-8974	572	4	yielded	yield	VERB
fnp-8974	572	5	an	an	DET
fnp-8974	572	6	average	average	NOUN
fnp-8974	572	7	of	of	ADP
fnp-8974	572	8	26.5	26.5	NUM
fnp-8974	572	9	million	million	NUM
fnp-8974	572	10	reads	read	NOUN
fnp-8974	572	11	per	per	ADP
fnp-8974	572	12	sample	sample	NOUN
fnp-8974	572	13	(	(	PUNCT
fnp-8974	572	14	range	range	NOUN
fnp-8974	572	15	:	:	PUNCT
fnp-8974	572	16	5.1–72.2	5.1–72.2	NUM
fnp-8974	572	17	million	million	NUM
fnp-8974	572	18	)	)	PUNCT
fnp-8974	572	19	,	,	PUNCT
fnp-8974	572	20	with	with	ADP
fnp-8974	572	21	a	a	DET
fnp-8974	572	22	mean	mean	ADJ
fnp-8974	572	23	off	off	ADP
fnp-8974	572	24	-	-	PUNCT
fnp-8974	572	25	target	target	NOUN
fnp-8974	572	26	rate	rate	NOUN
fnp-8974	572	27	of	of	ADP
fnp-8974	572	28	64.9	64.9	NUM
fnp-8974	572	29	 	 	SPACE
fnp-8974	572	30	%	%	NOUN
fnp-8974	572	31	(	(	PUNCT
fnp-8974	572	32	range	range	NOUN
fnp-8974	572	33	:	:	PUNCT
fnp-8974	572	34	45–92	45–92	NUM
fnp-8974	572	35	 	 	SPACE
fnp-8974	572	36	%	%	NOUN
fnp-8974	572	37	)	)	PUNCT
fnp-8974	572	38	.	.	PUNCT
fnp-8974	573	1	epic	epic	PROPN
fnp-8974	573	2	data	data	PROPN
fnp-8974	573	3	identified	identify	VERB
fnp-8974	573	4	260	260	NUM
fnp-8974	573	5	chromosomal	chromosomal	ADJ
fnp-8974	573	6	arm	arm	NOUN
fnp-8974	573	7	gains	gain	NOUN
fnp-8974	573	8	and	and	CCONJ
fnp-8974	573	9	271	271	NUM
fnp-8974	573	10	losses	loss	NOUN
fnp-8974	573	11	.	.	PUNCT
fnp-8974	574	1	ngs	ng	NOUN
fnp-8974	574	2	-	-	PUNCT
fnp-8974	574	3	derived	derive	VERB
fnp-8974	574	4	cnvs	cnvs	NOUN
fnp-8974	574	5	showed	show	VERB
fnp-8974	574	6	strong	strong	ADJ
fnp-8974	574	7	concordance	concordance	NOUN
fnp-8974	574	8	(	(	PUNCT
fnp-8974	574	9	average	average	ADJ
fnp-8974	574	10	r	r	NOUN
fnp-8974	574	11	 	 	SPACE
fnp-8974	574	12	=	=	NOUN
fnp-8974	574	13	 	 	SPACE
fnp-8974	574	14	0.915	0.915	NUM
fnp-8974	574	15	,	,	PUNCT
fnp-8974	574	16	p	p	X
fnp-8974	574	17	 	 	SPACE
fnp-8974	574	18	=	=	NOUN
fnp-8974	574	19	 	 	SPACE
fnp-8974	574	20	0.000014	0.000014	NUM
fnp-8974	574	21	)	)	PUNCT
fnp-8974	574	22	.	.	PUNCT
fnp-8974	575	1	hallmark	hallmark	PROPN
fnp-8974	575	2	alterations	alteration	NOUN
fnp-8974	575	3	,	,	PUNCT
fnp-8974	575	4	including	include	VERB
fnp-8974	575	5	+7/−10	+7/−10	NOUN
fnp-8974	575	6	and	and	CCONJ
fnp-8974	575	7	1p/19q	1p/19q	NOUN
fnp-8974	575	8	codeletion	codeletion	NOUN
fnp-8974	575	9	,	,	PUNCT
fnp-8974	575	10	were	be	AUX
fnp-8974	575	11	reliably	reliably	ADV
fnp-8974	575	12	detected	detect	VERB
fnp-8974	575	13	from	from	ADP
fnp-8974	575	14	off	off	ADP
fnp-8974	575	15	-	-	PUNCT
fnp-8974	575	16	target	target	NOUN
fnp-8974	575	17	reads	read	NOUN
fnp-8974	575	18	.	.	PUNCT
fnp-8974	576	1	nineteen	nineteen	NUM
fnp-8974	576	2	focal	focal	ADJ
fnp-8974	576	3	amplifications	amplification	NOUN
fnp-8974	576	4	were	be	AUX
fnp-8974	576	5	concordantly	concordantly	ADV
fnp-8974	576	6	identified	identify	VERB
fnp-8974	576	7	,	,	PUNCT
fnp-8974	576	8	including	include	VERB
fnp-8974	576	9	mdm4	mdm4	PROPN
fnp-8974	576	10	and	and	CCONJ
fnp-8974	576	11	mycn	mycn	PROPN
fnp-8974	576	12	,	,	PUNCT
fnp-8974	576	13	which	which	PRON
fnp-8974	576	14	were	be	AUX
fnp-8974	576	15	not	not	PART
fnp-8974	576	16	covered	cover	VERB
fnp-8974	576	17	by	by	ADP
fnp-8974	576	18	the	the	DET
fnp-8974	576	19	panel	panel	NOUN
fnp-8974	576	20	.	.	PUNCT
fnp-8974	577	1	of	of	ADP
fnp-8974	577	2	20	20	NUM
fnp-8974	577	3	homozygous	homozygous	ADJ
fnp-8974	577	4	deletions	deletion	NOUN
fnp-8974	577	5	identified	identify	VERB
fnp-8974	577	6	by	by	ADP
fnp-8974	577	7	the	the	DET
fnp-8974	577	8	array	array	NOUN
fnp-8974	577	9	,	,	PUNCT
fnp-8974	577	10	19	19	NUM
fnp-8974	577	11	(	(	PUNCT
fnp-8974	577	12	95	95	NUM
fnp-8974	577	13	 	 	SPACE
fnp-8974	577	14	%	%	NOUN
fnp-8974	577	15	)	)	PUNCT
fnp-8974	577	16	were	be	AUX
fnp-8974	577	17	also	also	ADV
fnp-8974	577	18	observed	observe	VERB
fnp-8974	577	19	in	in	ADP
fnp-8974	577	20	the	the	DET
fnp-8974	577	21	ngs	ng	NOUN
fnp-8974	577	22	data	datum	NOUN
fnp-8974	577	23	.	.	PUNCT
fnp-8974	578	1	conclusion	conclusion	NOUN
fnp-8974	578	2	:	:	PUNCT
fnp-8974	578	3	taken	take	VERB
fnp-8974	578	4	together	together	ADV
fnp-8974	578	5	,	,	PUNCT
fnp-8974	578	6	our	our	PRON
fnp-8974	578	7	findings	finding	NOUN
fnp-8974	578	8	demonstrate	demonstrate	VERB
fnp-8974	578	9	the	the	DET
fnp-8974	578	10	feasibility	feasibility	NOUN
fnp-8974	578	11	of	of	ADP
fnp-8974	578	12	using	use	VERB
fnp-8974	578	13	off	off	ADP
fnp-8974	578	14	-	-	PUNCT
fnp-8974	578	15	target	target	NOUN
fnp-8974	578	16	reads	read	NOUN
fnp-8974	578	17	for	for	ADP
fnp-8974	578	18	cnv	cnv	PROPN
fnp-8974	578	19	profiling	profiling	NOUN
fnp-8974	578	20	in	in	ADP
fnp-8974	578	21	cns	cns	PROPN
fnp-8974	578	22	tumors	tumor	NOUN
fnp-8974	578	23	,	,	PUNCT
fnp-8974	578	24	enabling	enable	VERB
fnp-8974	578	25	detection	detection	NOUN
fnp-8974	578	26	of	of	ADP
fnp-8974	578	27	clinically	clinically	ADV
fnp-8974	578	28	relevant	relevant	ADJ
fnp-8974	578	29	events	event	NOUN
fnp-8974	578	30	even	even	ADV
fnp-8974	578	31	outside	outside	ADP
fnp-8974	578	32	targeted	target	VERB
fnp-8974	578	33	regions	region	NOUN
fnp-8974	578	34	.	.	PUNCT
fnp-8974	579	1	p45	p45	PROPN
fnp-8974	579	2	free	free	ADJ
fnp-8974	579	3	neuropathol	neuropathol	NOUN
fnp-8974	579	4	6:17:66	6:17:66	NUM
fnp-8974	579	5	establishing	establish	VERB
fnp-8974	579	6	ultra	ultra	ADJ
fnp-8974	579	7	low	low	ADJ
fnp-8974	579	8	-	-	PUNCT
fnp-8974	579	9	input	input	NOUN
fnp-8974	579	10	spatial	spatial	ADJ
fnp-8974	579	11	proteomics	proteomic	NOUN
fnp-8974	579	12	for	for	ADP
fnp-8974	579	13	glioblastoma	glioblastoma	NOUN
fnp-8974	579	14	analysis	analysis	NOUN
fnp-8974	579	15	rhaissa	rhaissa	ADJ
fnp-8974	579	16	ribeiro	ribeiro	PROPN
fnp-8974	579	17	da	da	PROPN
fnp-8974	579	18	silva1	silva1	PROPN
fnp-8974	579	19	,	,	PUNCT
fnp-8974	579	20	daniela	daniela	PROPN
fnp-8974	579	21	valdes2	valdes2	PROPN
fnp-8974	579	22	,	,	PUNCT
fnp-8974	579	23	abigail	abigail	PROPN
fnp-8974	579	24	suwala1	suwala1	PROPN
fnp-8974	579	25	,	,	PUNCT
fnp-8974	579	26	philipp	philipp	PROPN
fnp-8974	579	27	sievers1	sievers1	PROPN
fnp-8974	579	28	,	,	PUNCT
fnp-8974	579	29	christel	christel	PROPN
fnp-8974	579	30	herold	herold	PROPN
fnp-8974	579	31	-	-	PUNCT
fnp-8974	579	32	mende1	mende1	PROPN
fnp-8974	579	33	,	,	PUNCT
fnp-8974	579	34	sandro	sandro	PROPN
fnp-8974	579	35	krieg1	krieg1	PROPN
fnp-8974	579	36	,	,	PUNCT
fnp-8974	579	37	wolfgang	wolfgang	PROPN
fnp-8974	579	38	wick1	wick1	PROPN
fnp-8974	579	39	,	,	PUNCT
fnp-8974	579	40	andreas	andreas	PROPN
fnp-8974	579	41	von	von	PROPN
fnp-8974	579	42	deimling1,3	deimling1,3	PROPN
fnp-8974	579	43	,	,	PUNCT
fnp-8974	579	44	gianluca	gianluca	PROPN
fnp-8974	579	45	sigismondo1	sigismondo1	PROPN
fnp-8974	579	46	,	,	PUNCT
fnp-8974	579	47	felix	felix	PROPN
fnp-8974	579	48	sahm1,3	sahm1,3	PROPN
fnp-8974	579	49	,	,	PUNCT
fnp-8974	579	50	fabian	fabian	PROPN
fnp-8974	579	51	coscia2	coscia2	PROPN
fnp-8974	579	52	,	,	PUNCT
fnp-8974	579	53	isabell	isabell	PROPN
fnp-8974	579	54	bludau1	bludau1	PROPN
fnp-8974	579	55	1	1	NUM
fnp-8974	579	56	university	university	NOUN
fnp-8974	579	57	hospital	hospital	NOUN
fnp-8974	579	58	,	,	PUNCT
fnp-8974	579	59	heidelberg	heidelberg	PROPN
fnp-8974	579	60	,	,	PUNCT
fnp-8974	579	61	germany	germany	PROPN
fnp-8974	579	62	2	2	NUM
fnp-8974	579	63	max	max	PROPN
fnp-8974	579	64	delbrück	delbrück	PROPN
fnp-8974	579	65	center	center	NOUN
fnp-8974	579	66	for	for	ADP
fnp-8974	579	67	molecular	molecular	ADJ
fnp-8974	579	68	medicine	medicine	NOUN
fnp-8974	579	69	(	(	PUNCT
fnp-8974	579	70	mdc	mdc	NOUN
fnp-8974	579	71	)	)	PUNCT
fnp-8974	579	72	,	,	PUNCT
fnp-8974	579	73	berlin	berlin	PROPN
fnp-8974	579	74	,	,	PUNCT
fnp-8974	579	75	germany	germany	PROPN
fnp-8974	579	76	3	3	NUM
fnp-8974	579	77	german	german	ADJ
fnp-8974	579	78	cancer	cancer	NOUN
fnp-8974	579	79	research	research	NOUN
fnp-8974	579	80	center	center	NOUN
fnp-8974	579	81	(	(	PUNCT
fnp-8974	579	82	dkfz	dkfz	PROPN
fnp-8974	579	83	)	)	PUNCT
fnp-8974	579	84	,	,	PUNCT
fnp-8974	579	85	heidelberg	heidelberg	PROPN
fnp-8974	579	86	,	,	PUNCT
fnp-8974	579	87	germany	germany	PROPN
fnp-8974	579	88	background	background	NOUN
fnp-8974	579	89	:	:	PUNCT
fnp-8974	579	90	glioblastoma	glioblastoma	NOUN
fnp-8974	579	91	shows	show	VERB
fnp-8974	579	92	pronounced	pronounce	VERB
fnp-8974	579	93	spatial	spatial	ADJ
fnp-8974	579	94	heterogeneity	heterogeneity	NOUN
fnp-8974	579	95	that	that	PRON
fnp-8974	579	96	impacts	impact	VERB
fnp-8974	579	97	its	its	PRON
fnp-8974	579	98	aggressive	aggressive	ADJ
fnp-8974	579	99	behavior	behavior	NOUN
fnp-8974	579	100	and	and	CCONJ
fnp-8974	579	101	therapy	therapy	NOUN
fnp-8974	579	102	resistance	resistance	NOUN
fnp-8974	579	103	.	.	PUNCT
fnp-8974	580	1	high	high	ADJ
fnp-8974	580	2	-	-	PUNCT
fnp-8974	580	3	resolution	resolution	NOUN
fnp-8974	580	4	spatial	spatial	ADJ
fnp-8974	580	5	proteomics	proteomic	NOUN
fnp-8974	580	6	is	be	AUX
fnp-8974	580	7	needed	need	VERB
fnp-8974	580	8	to	to	PART
fnp-8974	580	9	characterize	characterize	VERB
fnp-8974	580	10	distinct	distinct	ADJ
fnp-8974	580	11	tumor	tumor	NOUN
fnp-8974	580	12	microenvironments	microenvironment	NOUN
fnp-8974	580	13	at	at	ADP
fnp-8974	580	14	the	the	DET
fnp-8974	580	15	protein	protein	NOUN
fnp-8974	580	16	level	level	NOUN
fnp-8974	580	17	,	,	PUNCT
fnp-8974	580	18	which	which	PRON
fnp-8974	580	19	can	can	AUX
fnp-8974	580	20	not	not	PART
fnp-8974	580	21	be	be	AUX
fnp-8974	580	22	fully	fully	ADV
fnp-8974	580	23	captured	capture	VERB
fnp-8974	580	24	by	by	ADP
fnp-8974	580	25	transcriptomics	transcriptomic	NOUN
fnp-8974	580	26	alone	alone	ADV
fnp-8974	580	27	.	.	PUNCT
fnp-8974	581	1	objective(s	objective(s	NOUN
fnp-8974	581	2	):	):	PUNCT
fnp-8974	581	3	to	to	PART
fnp-8974	581	4	establish	establish	VERB
fnp-8974	581	5	an	an	DET
fnp-8974	581	6	ultra	ultra	ADJ
fnp-8974	581	7	-	-	ADJ
fnp-8974	581	8	low	low	ADJ
fnp-8974	581	9	-	-	PUNCT
fnp-8974	581	10	input	input	NOUN
fnp-8974	581	11	spatial	spatial	ADJ
fnp-8974	581	12	proteomics	proteomic	NOUN
fnp-8974	581	13	workflow	workflow	NOUN
fnp-8974	581	14	enabling	enable	VERB
fnp-8974	581	15	the	the	DET
fnp-8974	581	16	identification	identification	NOUN
fnp-8974	581	17	of	of	ADP
fnp-8974	581	18	thousands	thousand	NOUN
fnp-8974	581	19	of	of	ADP
fnp-8974	581	20	proteins	protein	NOUN
fnp-8974	581	21	from	from	ADP
fnp-8974	581	22	minute	minute	NOUN
fnp-8974	581	23	,	,	PUNCT
fnp-8974	581	24	laser	laser	NOUN
fnp-8974	581	25	-	-	PUNCT
fnp-8974	581	26	microdissected	microdissecte	VERB
fnp-8974	581	27	glioblastoma	glioblastoma	NOUN
fnp-8974	581	28	tissue	tissue	NOUN
fnp-8974	581	29	regions	region	NOUN
fnp-8974	581	30	.	.	PUNCT
fnp-8974	582	1	this	this	DET
fnp-8974	582	2	approach	approach	NOUN
fnp-8974	582	3	aims	aim	VERB
fnp-8974	582	4	to	to	PART
fnp-8974	582	5	facilitate	facilitate	VERB
fnp-8974	582	6	detailed	detailed	ADJ
fnp-8974	582	7	molecular	molecular	ADJ
fnp-8974	582	8	profiling	profiling	NOUN
fnp-8974	582	9	of	of	ADP
fnp-8974	582	10	heterogeneous	heterogeneous	ADJ
fnp-8974	582	11	tumor	tumor	NOUN
fnp-8974	582	12	areas	area	NOUN
fnp-8974	582	13	.	.	PUNCT
fnp-8974	583	1	question(s	question(s	PROPN
fnp-8974	583	2	):	):	PUNCT
fnp-8974	583	3	can	can	AUX
fnp-8974	583	4	this	this	DET
fnp-8974	583	5	workflow	workflow	NOUN
fnp-8974	583	6	detect	detect	VERB
fnp-8974	583	7	spatial	spatial	ADJ
fnp-8974	583	8	protein	protein	NOUN
fnp-8974	583	9	gradients	gradient	NOUN
fnp-8974	583	10	within	within	ADP
fnp-8974	583	11	glioblastoma	glioblastoma	NOUN
fnp-8974	583	12	microenvironments	microenvironment	NOUN
fnp-8974	583	13	?	?	PUNCT
fnp-8974	584	1	how	how	SCONJ
fnp-8974	584	2	can	can	AUX
fnp-8974	584	3	such	such	ADJ
fnp-8974	584	4	data	datum	NOUN
fnp-8974	584	5	support	support	VERB
fnp-8974	584	6	future	future	ADJ
fnp-8974	584	7	investigations	investigation	NOUN
fnp-8974	584	8	of	of	ADP
fnp-8974	584	9	biologically	biologically	ADV
fnp-8974	584	10	relevant	relevant	ADJ
fnp-8974	584	11	tumor	tumor	NOUN
fnp-8974	584	12	niches	niche	NOUN
fnp-8974	584	13	?	?	PUNCT
fnp-8974	585	1	method(s	method(	VERB
fnp-8974	585	2	):	):	PUNCT
fnp-8974	585	3	glioblastoma	glioblastoma	NOUN
fnp-8974	585	4	sections	section	NOUN
fnp-8974	585	5	are	be	AUX
fnp-8974	585	6	annotated	annotate	VERB
fnp-8974	585	7	after	after	ADP
fnp-8974	585	8	h&e	h&e	PROPN
fnp-8974	585	9	staining	stain	VERB
fnp-8974	585	10	,	,	PUNCT
fnp-8974	585	11	followed	follow	VERB
fnp-8974	585	12	by	by	ADP
fnp-8974	585	13	precise	precise	ADJ
fnp-8974	585	14	laser	laser	NOUN
fnp-8974	585	15	microdissection	microdissection	NOUN
fnp-8974	585	16	(	(	PUNCT
fnp-8974	585	17	~30,000	~30,000	PRON
fnp-8974	585	18	 	 	SPACE
fnp-8974	585	19	μm²	μm²	NOUN
fnp-8974	585	20	equivalent	equivalent	ADJ
fnp-8974	585	21	to	to	ADP
fnp-8974	585	22	~250	~250	ADJ
fnp-8974	585	23	cell	cell	NOUN
fnp-8974	585	24	bodies	body	NOUN
fnp-8974	585	25	)	)	PUNCT
fnp-8974	585	26	of	of	ADP
fnp-8974	585	27	morphologically	morphologically	ADV
fnp-8974	585	28	distinct	distinct	ADJ
fnp-8974	585	29	tumor	tumor	NOUN
fnp-8974	585	30	regions	region	NOUN
fnp-8974	585	31	.	.	PUNCT
fnp-8974	586	1	proteins	protein	NOUN
fnp-8974	586	2	are	be	AUX
fnp-8974	586	3	analyzed	analyze	VERB
fnp-8974	586	4	via	via	ADP
fnp-8974	586	5	highly	highly	ADV
fnp-8974	586	6	sensitive	sensitive	ADJ
fnp-8974	586	7	lc	lc	PROPN
fnp-8974	586	8	-	-	PUNCT
fnp-8974	586	9	ms	ms	PROPN
fnp-8974	586	10	/	/	SYM
fnp-8974	586	11	ms	ms	NOUN
fnp-8974	586	12	with	with	ADP
fnp-8974	586	13	an	an	DET
fnp-8974	586	14	optimized	optimize	VERB
fnp-8974	586	15	ultra	ultra	ADJ
fnp-8974	586	16	-	-	ADJ
fnp-8974	586	17	low	low	ADJ
fnp-8974	586	18	-	-	PUNCT
fnp-8974	586	19	input	input	NOUN
fnp-8974	586	20	protocol	protocol	NOUN
fnp-8974	586	21	.	.	PUNCT
fnp-8974	587	1	result(s	result(s	PROPN
fnp-8974	587	2	):	):	PUNCT
fnp-8974	587	3	using	use	VERB
fnp-8974	587	4	this	this	DET
fnp-8974	587	5	workflow	workflow	NOUN
fnp-8974	587	6	,	,	PUNCT
fnp-8974	587	7	we	we	PRON
fnp-8974	587	8	are	be	AUX
fnp-8974	587	9	able	able	ADJ
fnp-8974	587	10	to	to	PART
fnp-8974	587	11	identify	identify	VERB
fnp-8974	587	12	approximately	approximately	ADV
fnp-8974	587	13	3,500	3,500	NUM
fnp-8974	587	14	proteins	protein	NOUN
fnp-8974	587	15	per	per	ADP
fnp-8974	587	16	microdissected	microdissected	ADJ
fnp-8974	587	17	region	region	NOUN
fnp-8974	587	18	.	.	PUNCT
fnp-8974	588	1	this	this	DET
fnp-8974	588	2	high	high	ADJ
fnp-8974	588	3	sensitivity	sensitivity	NOUN
fnp-8974	588	4	and	and	CCONJ
fnp-8974	588	5	spatial	spatial	ADJ
fnp-8974	588	6	resolution	resolution	NOUN
fnp-8974	588	7	provide	provide	VERB
fnp-8974	588	8	a	a	DET
fnp-8974	588	9	powerful	powerful	ADJ
fnp-8974	588	10	basis	basis	NOUN
fnp-8974	588	11	for	for	ADP
fnp-8974	588	12	future	future	ADJ
fnp-8974	588	13	applications	application	NOUN
fnp-8974	588	14	,	,	PUNCT
fnp-8974	588	15	such	such	ADJ
fnp-8974	588	16	as	as	ADP
fnp-8974	588	17	analyzing	analyze	VERB
fnp-8974	588	18	perinecrotic	perinecrotic	ADJ
fnp-8974	588	19	zones	zone	NOUN
fnp-8974	588	20	to	to	PART
fnp-8974	588	21	explore	explore	VERB
fnp-8974	588	22	spatially	spatially	ADV
fnp-8974	588	23	resolved	resolve	VERB
fnp-8974	588	24	protein	protein	NOUN
fnp-8974	588	25	expression	expression	NOUN
fnp-8974	588	26	patterns	pattern	NOUN
fnp-8974	588	27	relevant	relevant	ADJ
fnp-8974	588	28	to	to	ADP
fnp-8974	588	29	tumor	tumor	NOUN
fnp-8974	588	30	progression	progression	NOUN
fnp-8974	588	31	.	.	PUNCT
fnp-8974	589	1	conclusion(s	conclusion(s	NOUN
fnp-8974	589	2	):	):	PUNCT
fnp-8974	589	3	the	the	DET
fnp-8974	589	4	established	establish	VERB
fnp-8974	589	5	ultra	ultra	ADJ
fnp-8974	589	6	-	-	ADJ
fnp-8974	589	7	low	low	ADJ
fnp-8974	589	8	-	-	PUNCT
fnp-8974	589	9	input	input	NOUN
fnp-8974	589	10	spatial	spatial	ADJ
fnp-8974	589	11	proteomics	proteomic	NOUN
fnp-8974	589	12	workflow	workflow	NOUN
fnp-8974	589	13	offers	offer	VERB
fnp-8974	589	14	a	a	DET
fnp-8974	589	15	robust	robust	ADJ
fnp-8974	589	16	platform	platform	NOUN
fnp-8974	589	17	for	for	ADP
fnp-8974	589	18	investigating	investigate	VERB
fnp-8974	589	19	glioblastoma	glioblastoma	NOUN
fnp-8974	589	20	heterogeneity	heterogeneity	NOUN
fnp-8974	589	21	at	at	ADP
fnp-8974	589	22	the	the	DET
fnp-8974	589	23	protein	protein	NOUN
fnp-8974	589	24	level	level	NOUN
fnp-8974	589	25	.	.	PUNCT
fnp-8974	590	1	it	it	PRON
fnp-8974	590	2	enables	enable	VERB
fnp-8974	590	3	detailed	detailed	ADJ
fnp-8974	590	4	studies	study	NOUN
fnp-8974	590	5	of	of	ADP
fnp-8974	590	6	tumor	tumor	NOUN
fnp-8974	590	7	microenvironments	microenvironment	NOUN
fnp-8974	590	8	and	and	CCONJ
fnp-8974	590	9	supports	support	VERB
fnp-8974	590	10	the	the	DET
fnp-8974	590	11	discovery	discovery	NOUN
fnp-8974	590	12	of	of	ADP
fnp-8974	590	13	spatially	spatially	ADV
fnp-8974	590	14	distinct	distinct	ADJ
fnp-8974	590	15	biomarkers	biomarker	NOUN
fnp-8974	590	16	and	and	CCONJ
fnp-8974	590	17	therapeutic	therapeutic	ADJ
fnp-8974	590	18	targets	target	NOUN
fnp-8974	590	19	.	.	PUNCT
fnp-8974	591	1	p46	p46	VERB
fnp-8974	591	2	free	free	ADJ
fnp-8974	591	3	neuropathol	neuropathol	NOUN
fnp-8974	592	1	6:17:67	6:17:67	NUM
fnp-8974	592	2	comparison	comparison	NOUN
fnp-8974	592	3	of	of	ADP
fnp-8974	592	4	diffuse	diffuse	ADJ
fnp-8974	592	5	glioma	glioma	NOUN
fnp-8974	592	6	types	type	NOUN
fnp-8974	592	7	with	with	ADP
fnp-8974	592	8	gliomatosis	gliomatosis	NOUN
fnp-8974	592	9	cerebri	cerebri	NOUN
fnp-8974	592	10	growth	growth	NOUN
fnp-8974	592	11	pattern	pattern	NOUN
fnp-8974	592	12	in	in	ADP
fnp-8974	592	13	adult	adult	NOUN
fnp-8974	592	14	patients	patient	NOUN
fnp-8974	592	15	marco	marco	PROPN
fnp-8974	592	16	münzberg1	münzberg1	PROPN
fnp-8974	592	17	,	,	PUNCT
fnp-8974	592	18	franziska	franziska	PROPN
fnp-8974	592	19	maria	maria	PROPN
fnp-8974	592	20	ippen2,3,4	ippen2,3,4	ADJ
fnp-8974	592	21	,	,	PUNCT
fnp-8974	592	22	iris	iris	NOUN
fnp-8974	592	23	divé5	divé5	PROPN
fnp-8974	592	24	,	,	PUNCT
fnp-8974	592	25	charlotte	charlotte	PROPN
fnp-8974	592	26	brandenburg1	brandenburg1	PROPN
fnp-8974	592	27	,	,	PUNCT
fnp-8974	592	28	philipp	philipp	PROPN
fnp-8974	592	29	sievers4,6,7	sievers4,6,7	PROPN
fnp-8974	592	30	,	,	PUNCT
fnp-8974	592	31	mustafa	mustafa	PROPN
fnp-8974	592	32	mahmutoglu8	mahmutoglu8	PROPN
fnp-8974	592	33	,	,	PUNCT
fnp-8974	592	34	marianne	marianne	PROPN
fnp-8974	592	35	schell8	schell8	PROPN
fnp-8974	592	36	,	,	PUNCT
fnp-8974	592	37	katharina	katharina	PROPN
fnp-8974	592	38	schregel8,9	schregel8,9	PROPN
fnp-8974	592	39	,	,	PUNCT
fnp-8974	592	40	katharina	katharina	PROPN
fnp-8974	592	41	wenger	wenger	PROPN
fnp-8974	592	42	-	-	PUNCT
fnp-8974	592	43	alakmeh10	alakmeh10	PROPN
fnp-8974	592	44	,	,	PUNCT
fnp-8974	592	45	leonille	leonille	NOUN
fnp-8974	592	46	schweizer1,11	schweizer1,11	X
fnp-8974	592	47	1	1	NUM
fnp-8974	592	48	institute	institute	NOUN
fnp-8974	592	49	of	of	ADP
fnp-8974	592	50	neurology	neurology	NOUN
fnp-8974	592	51	(	(	PUNCT
fnp-8974	592	52	edinger	edinger	PROPN
fnp-8974	592	53	institute	institute	PROPN
fnp-8974	592	54	)	)	PUNCT
fnp-8974	592	55	,	,	PUNCT
fnp-8974	592	56	university	university	NOUN
fnp-8974	592	57	hospital	hospital	NOUN
fnp-8974	592	58	frankfurt	frankfurt	PROPN
fnp-8974	592	59	,	,	PUNCT
fnp-8974	592	60	goethe	goethe	PROPN
fnp-8974	592	61	university	university	PROPN
fnp-8974	592	62	,	,	PUNCT
fnp-8974	592	63	frankfurt	frankfurt	PROPN
fnp-8974	592	64	am	be	AUX
fnp-8974	592	65	main	main	ADJ
fnp-8974	592	66	,	,	PUNCT
fnp-8974	592	67	germany	germany	PROPN
fnp-8974	592	68	2	2	NUM
fnp-8974	592	69	national	national	ADJ
fnp-8974	592	70	centre	centre	NOUN
fnp-8974	592	71	for	for	ADP
fnp-8974	592	72	tumour	tumour	NOUN
fnp-8974	592	73	diseases	disease	NOUN
fnp-8974	592	74	(	(	PUNCT
fnp-8974	592	75	nct	nct	NOUN
fnp-8974	592	76	)	)	PUNCT
fnp-8974	592	77	,	,	PUNCT
fnp-8974	592	78	nct	nct	PROPN
fnp-8974	592	79	heidelberg	heidelberg	PROPN
fnp-8974	592	80	,	,	PUNCT
fnp-8974	592	81	a	a	DET
fnp-8974	592	82	partnership	partnership	NOUN
fnp-8974	592	83	between	between	ADP
fnp-8974	592	84	dkfz	dkfz	NOUN
fnp-8974	592	85	and	and	CCONJ
fnp-8974	592	86	university	university	NOUN
fnp-8974	592	87	hospital	hospital	NOUN
fnp-8974	592	88	heidelberg	heidelberg	PROPN
fnp-8974	592	89	,	,	PUNCT
fnp-8974	592	90	heidelberg	heidelberg	PROPN
fnp-8974	592	91	,	,	PUNCT
fnp-8974	592	92	germany	germany	PROPN
fnp-8974	592	93	3	3	NUM
fnp-8974	592	94	department	department	PROPN
fnp-8974	592	95	of	of	ADP
fnp-8974	592	96	neurology	neurology	NOUN
fnp-8974	592	97	,	,	PUNCT
fnp-8974	592	98	university	university	NOUN
fnp-8974	592	99	hospital	hospital	NOUN
fnp-8974	592	100	heidelberg	heidelberg	PROPN
fnp-8974	592	101	,	,	PUNCT
fnp-8974	592	102	heidelberg	heidelberg	PROPN
fnp-8974	592	103	,	,	PUNCT
fnp-8974	592	104	germany	germany	PROPN
fnp-8974	592	105	4	4	NUM
fnp-8974	592	106	clinical	clinical	ADJ
fnp-8974	592	107	cooperation	cooperation	NOUN
fnp-8974	592	108	unit	unit	NOUN
fnp-8974	592	109	neuropathology	neuropathology	NOUN
fnp-8974	592	110	,	,	PUNCT
fnp-8974	592	111	german	german	ADJ
fnp-8974	592	112	cancer	cancer	NOUN
fnp-8974	592	113	research	research	NOUN
fnp-8974	592	114	centre	centre	NOUN
fnp-8974	592	115	(	(	PUNCT
fnp-8974	592	116	dkfz	dkfz	PROPN
fnp-8974	592	117	)	)	PUNCT
fnp-8974	592	118	,	,	PUNCT
fnp-8974	592	119	german	german	ADJ
fnp-8974	592	120	consortium	consortium	NOUN
fnp-8974	592	121	for	for	ADP
fnp-8974	592	122	translational	translational	ADJ
fnp-8974	592	123	cancer	cancer	NOUN
fnp-8974	592	124	research	research	NOUN
fnp-8974	592	125	(	(	PUNCT
fnp-8974	592	126	dktk	dktk	NOUN
fnp-8974	592	127	)	)	PUNCT
fnp-8974	592	128	,	,	PUNCT
fnp-8974	592	129	heidelberg	heidelberg	PROPN
fnp-8974	592	130	,	,	PUNCT
fnp-8974	592	131	germany	germany	PROPN
fnp-8974	592	132	5	5	NUM
fnp-8974	592	133	dr	dr	PROPN
fnp-8974	592	134	.	.	PROPN
fnp-8974	592	135	senckenberg	senckenberg	PROPN
fnp-8974	592	136	institute	institute	PROPN
fnp-8974	592	137	of	of	ADP
fnp-8974	592	138	neurooncology	neurooncology	PROPN
fnp-8974	592	139	,	,	PUNCT
fnp-8974	592	140	university	university	NOUN
fnp-8974	592	141	hospital	hospital	NOUN
fnp-8974	592	142	frankfurt	frankfurt	PROPN
fnp-8974	592	143	,	,	PUNCT
fnp-8974	592	144	goethe	goethe	PROPN
fnp-8974	592	145	university	university	PROPN
fnp-8974	592	146	,	,	PUNCT
fnp-8974	592	147	frankfurt	frankfurt	PROPN
fnp-8974	592	148	am	be	AUX
fnp-8974	592	149	main	main	ADJ
fnp-8974	592	150	,	,	PUNCT
fnp-8974	592	151	germany	germany	PROPN
fnp-8974	592	152	6	6	NUM
fnp-8974	592	153	department	department	NOUN
fnp-8974	592	154	of	of	ADP
fnp-8974	592	155	neuropathology	neuropathology	NOUN
fnp-8974	592	156	,	,	PUNCT
fnp-8974	592	157	institute	institute	PROPN
fnp-8974	592	158	of	of	ADP
fnp-8974	592	159	pathology	pathology	PROPN
fnp-8974	592	160	,	,	PUNCT
fnp-8974	592	161	university	university	NOUN
fnp-8974	592	162	hospital	hospital	NOUN
fnp-8974	592	163	heidelberg	heidelberg	PROPN
fnp-8974	592	164	,	,	PUNCT
fnp-8974	592	165	heidelberg	heidelberg	PROPN
fnp-8974	592	166	,	,	PUNCT
fnp-8974	592	167	germany	germany	PROPN
fnp-8974	592	168	7	7	NUM
fnp-8974	592	169	hopp	hopp	PROPN
fnp-8974	592	170	children	children	PROPN
fnp-8974	592	171	's	's	PART
fnp-8974	592	172	cancer	cancer	NOUN
fnp-8974	592	173	centre	centre	PROPN
fnp-8974	592	174	heidelberg	heidelberg	PROPN
fnp-8974	592	175	(	(	PUNCT
fnp-8974	592	176	kitz	kitz	PROPN
fnp-8974	592	177	)	)	PUNCT
fnp-8974	592	178	,	,	PUNCT
fnp-8974	592	179	heidelberg	heidelberg	PROPN
fnp-8974	592	180	,	,	PUNCT
fnp-8974	592	181	germany	germany	PROPN
fnp-8974	592	182	8	8	NUM
fnp-8974	592	183	department	department	PROPN
fnp-8974	592	184	of	of	ADP
fnp-8974	592	185	neuroradiology	neuroradiology	PROPN
fnp-8974	592	186	,	,	PUNCT
fnp-8974	592	187	heidelberg	heidelberg	PROPN
fnp-8974	592	188	university	university	PROPN
fnp-8974	592	189	hospital	hospital	NOUN
fnp-8974	592	190	,	,	PUNCT
fnp-8974	592	191	heidelberg	heidelberg	PROPN
fnp-8974	592	192	,	,	PUNCT
fnp-8974	592	193	germany	germany	PROPN
fnp-8974	592	194	9	9	NUM
fnp-8974	592	195	clinical	clinical	ADJ
fnp-8974	592	196	cooperation	cooperation	NOUN
fnp-8974	592	197	unit	unit	NOUN
fnp-8974	592	198	neurooncology	neurooncology	NOUN
fnp-8974	592	199	,	,	PUNCT
fnp-8974	592	200	german	german	ADJ
fnp-8974	592	201	cancer	cancer	NOUN
fnp-8974	592	202	research	research	NOUN
fnp-8974	592	203	centre	centre	NOUN
fnp-8974	592	204	(	(	PUNCT
fnp-8974	592	205	dkfz	dkfz	PROPN
fnp-8974	592	206	)	)	PUNCT
fnp-8974	592	207	,	,	PUNCT
fnp-8974	592	208	heidelberg	heidelberg	PROPN
fnp-8974	592	209	,	,	PUNCT
fnp-8974	592	210	germany	germany	PROPN
fnp-8974	592	211	10	10	NUM
fnp-8974	592	212	institute	institute	PROPN
fnp-8974	592	213	of	of	ADP
fnp-8974	592	214	neuroradiology	neuroradiology	NOUN
fnp-8974	592	215	,	,	PUNCT
fnp-8974	592	216	university	university	PROPN
fnp-8974	592	217	of	of	ADP
fnp-8974	592	218	frankfurt	frankfurt	PROPN
fnp-8974	592	219	am	be	AUX
fnp-8974	592	220	main	main	ADJ
fnp-8974	592	221	/	/	SYM
fnp-8974	592	222	brain	brain	NOUN
fnp-8974	592	223	imaging	imaging	NOUN
fnp-8974	592	224	centre	centre	PROPN
fnp-8974	592	225	frankfurt	frankfurt	PROPN
fnp-8974	592	226	am	be	AUX
fnp-8974	592	227	main	main	ADJ
fnp-8974	592	228	,	,	PUNCT
fnp-8974	592	229	frankfurt	frankfurt	PROPN
fnp-8974	592	230	am	be	AUX
fnp-8974	592	231	main	main	ADJ
fnp-8974	592	232	,	,	PUNCT
fnp-8974	592	233	germany	germany	NOUN
fnp-8974	592	234	11	11	NUM
fnp-8974	592	235	german	german	ADJ
fnp-8974	592	236	cancer	cancer	NOUN
fnp-8974	592	237	consortium	consortium	NOUN
fnp-8974	592	238	(	(	PUNCT
fnp-8974	592	239	dktk	dktk	NOUN
fnp-8974	592	240	)	)	PUNCT
fnp-8974	592	241	,	,	PUNCT
fnp-8974	592	242	partner	partner	NOUN
fnp-8974	592	243	site	site	NOUN
fnp-8974	592	244	frankfurt	frankfurt	PROPN
fnp-8974	592	245	am	be	AUX
fnp-8974	592	246	mainz	mainz	ADJ
fnp-8974	592	247	,	,	PUNCT
fnp-8974	592	248	german	german	ADJ
fnp-8974	592	249	cancer	cancer	NOUN
fnp-8974	592	250	research	research	NOUN
fnp-8974	592	251	centre	centre	NOUN
fnp-8974	592	252	(	(	PUNCT
fnp-8974	592	253	dkfz	dkfz	PROPN
fnp-8974	592	254	)	)	PUNCT
fnp-8974	592	255	,	,	PUNCT
fnp-8974	592	256	heidelberg	heidelberg	PROPN
fnp-8974	592	257	,	,	PUNCT
fnp-8974	592	258	germany	germany	PROPN
fnp-8974	592	259	gliomatosis	gliomatosis	PROPN
fnp-8974	592	260	cerebri	cerebri	NOUN
fnp-8974	592	261	(	(	PUNCT
fnp-8974	592	262	gc	gc	PROPN
fnp-8974	592	263	)	)	PUNCT
fnp-8974	592	264	type	type	NOUN
fnp-8974	592	265	1	1	NUM
fnp-8974	592	266	is	be	AUX
fnp-8974	592	267	characterised	characterise	VERB
fnp-8974	592	268	by	by	ADP
fnp-8974	592	269	diffuse	diffuse	NOUN
fnp-8974	592	270	infiltration	infiltration	NOUN
fnp-8974	592	271	of	of	ADP
fnp-8974	592	272	glioma	glioma	NOUN
fnp-8974	592	273	cells	cell	NOUN
fnp-8974	592	274	spanning	span	VERB
fnp-8974	592	275	three	three	NUM
fnp-8974	592	276	or	or	CCONJ
fnp-8974	592	277	more	more	ADJ
fnp-8974	592	278	cerebral	cerebral	ADJ
fnp-8974	592	279	lobes	lobe	NOUN
fnp-8974	592	280	without	without	ADP
fnp-8974	592	281	contrast	contrast	NOUN
fnp-8974	592	282	enhancement	enhancement	NOUN
fnp-8974	592	283	.	.	PUNCT
fnp-8974	593	1	its	its	PRON
fnp-8974	593	2	prevalence	prevalence	NOUN
fnp-8974	593	3	and	and	CCONJ
fnp-8974	593	4	clinical	clinical	ADJ
fnp-8974	593	5	relevance	relevance	NOUN
fnp-8974	593	6	across	across	ADP
fnp-8974	593	7	glioma	glioma	NOUN
fnp-8974	593	8	subtypes	subtype	NOUN
fnp-8974	593	9	remain	remain	AUX
fnp-8974	593	10	incompletely	incompletely	ADV
fnp-8974	593	11	understood	understand	VERB
fnp-8974	593	12	.	.	PUNCT
fnp-8974	594	1	in	in	ADP
fnp-8974	594	2	a	a	DET
fnp-8974	594	3	cohort	cohort	NOUN
fnp-8974	594	4	of	of	ADP
fnp-8974	594	5	853	853	NUM
fnp-8974	594	6	gliomas	glioma	NOUN
fnp-8974	594	7	epigenetically	epigenetically	ADV
fnp-8974	594	8	profiled	profile	VERB
fnp-8974	594	9	between	between	ADP
fnp-8974	594	10	2017	2017	NUM
fnp-8974	594	11	to	to	ADP
fnp-8974	594	12	2025	2025	NUM
fnp-8974	594	13	,	,	PUNCT
fnp-8974	594	14	gc	gc	PROPN
fnp-8974	594	15	was	be	AUX
fnp-8974	594	16	found	find	VERB
fnp-8974	594	17	in	in	ADP
fnp-8974	594	18	1	1	NUM
fnp-8974	594	19	 	 	SPACE
fnp-8974	594	20	%	%	NOUN
fnp-8974	594	21	of	of	ADP
fnp-8974	594	22	glioblastomas	glioblastoma	NOUN
fnp-8974	594	23	,	,	PUNCT
fnp-8974	594	24	idh	idh	PROPN
fnp-8974	594	25	wildtype	wildtype	NOUN
fnp-8974	594	26	(	(	PUNCT
fnp-8974	594	27	gbm	gbm	NOUN
fnp-8974	594	28	;	;	PUNCT
fnp-8974	594	29	5/587	5/587	NUM
fnp-8974	594	30	)	)	PUNCT
fnp-8974	594	31	,	,	PUNCT
fnp-8974	594	32	4.5	4.5	NUM
fnp-8974	594	33	 	 	SPACE
fnp-8974	594	34	%	%	NOUN
fnp-8974	594	35	of	of	ADP
fnp-8974	594	36	oligodendrogliomas	oligodendroglioma	NOUN
fnp-8974	594	37	,	,	PUNCT
fnp-8974	594	38	idh	idh	NOUN
fnp-8974	594	39	-	-	PUNCT
fnp-8974	594	40	mutant	mutant	NOUN
fnp-8974	594	41	and	and	CCONJ
fnp-8974	594	42	1p/19q	1p/19q	NOUN
fnp-8974	594	43	-	-	PUNCT
fnp-8974	594	44	codeleted	codelete	VERB
fnp-8974	594	45	(	(	PUNCT
fnp-8974	594	46	4/88	4/88	NUM
fnp-8974	594	47	)	)	PUNCT
fnp-8974	594	48	,	,	PUNCT
fnp-8974	594	49	2.8	2.8	NUM
fnp-8974	594	50	 	 	SPACE
fnp-8974	594	51	%	%	NOUN
fnp-8974	594	52	of	of	ADP
fnp-8974	594	53	astrocytomas	astrocytoma	NOUN
fnp-8974	594	54	,	,	PUNCT
fnp-8974	594	55	idh	idh	NOUN
fnp-8974	594	56	-	-	PUNCT
fnp-8974	594	57	mutant	mutant	NOUN
fnp-8974	594	58	(	(	PUNCT
fnp-8974	594	59	3/108	3/108	NUM
fnp-8974	594	60	)	)	PUNCT
fnp-8974	594	61	,	,	PUNCT
fnp-8974	594	62	4	4	NUM
fnp-8974	594	63	 	 	SPACE
fnp-8974	594	64	%	%	NOUN
fnp-8974	594	65	of	of	ADP
fnp-8974	594	66	diffuse	diffuse	NOUN
fnp-8974	594	67	paediatric	paediatric	ADJ
fnp-8974	594	68	-	-	PUNCT
fnp-8974	594	69	type	type	NOUN
fnp-8974	594	70	high	high	ADJ
fnp-8974	594	71	-	-	PUNCT
fnp-8974	594	72	grade	grade	NOUN
fnp-8974	594	73	gliomas	glioma	NOUN
fnp-8974	594	74	,	,	PUNCT
fnp-8974	594	75	h3	h3	NOUN
fnp-8974	594	76	-	-	PUNCT
fnp-8974	594	77	wildtype	wildtype	NOUN
fnp-8974	594	78	and	and	CCONJ
fnp-8974	594	79	idh	idh	NOUN
fnp-8974	594	80	-	-	PUNCT
fnp-8974	594	81	wildtype	wildtype	NOUN
fnp-8974	594	82	(	(	PUNCT
fnp-8974	594	83	2/54	2/54	NUM
fnp-8974	594	84	)	)	PUNCT
fnp-8974	594	85	,	,	PUNCT
fnp-8974	594	86	and	and	CCONJ
fnp-8974	594	87	69	69	NUM
fnp-8974	594	88	 	 	SPACE
fnp-8974	594	89	%	%	NOUN
fnp-8974	594	90	of	of	ADP
fnp-8974	594	91	the	the	DET
fnp-8974	594	92	novel	novel	ADJ
fnp-8974	594	93	glioma	glioma	NOUN
fnp-8974	594	94	type	type	NOUN
fnp-8974	594	95	"	"	PUNCT
fnp-8974	594	96	gliomatosis	gliomatosis	NOUN
fnp-8974	594	97	cerebri	cerebri	NOUN
fnp-8974	594	98	-	-	PUNCT
fnp-8974	594	99	like	like	ADJ
fnp-8974	594	100	gliomas	glioma	NOUN
fnp-8974	594	101	,	,	PUNCT
fnp-8974	594	102	idh	idh	NOUN
fnp-8974	594	103	-	-	PUNCT
fnp-8974	594	104	wildtype	wildtype	NOUN
fnp-8974	594	105	"	"	PUNCT
fnp-8974	594	106	(	(	PUNCT
fnp-8974	594	107	gclg	gclg	NOUN
fnp-8974	594	108	,	,	PUNCT
fnp-8974	594	109	11/16	11/16	NUM
fnp-8974	594	110	)	)	PUNCT
fnp-8974	594	111	.	.	PUNCT
fnp-8974	595	1	gliomas	glioma	NOUN
fnp-8974	595	2	exhibiting	exhibit	VERB
fnp-8974	595	3	the	the	DET
fnp-8974	595	4	gc	gc	PROPN
fnp-8974	595	5	phenotype	phenotype	NOUN
fnp-8974	595	6	showed	show	VERB
fnp-8974	595	7	significantly	significantly	ADV
fnp-8974	595	8	higher	high	ADJ
fnp-8974	595	9	mgmt	mgmt	PROPN
fnp-8974	595	10	promoter	promoter	NOUN
fnp-8974	595	11	methylation	methylation	NOUN
fnp-8974	595	12	rates	rate	NOUN
fnp-8974	595	13	compared	compare	VERB
fnp-8974	595	14	with	with	ADP
fnp-8974	595	15	non	non	ADJ
fnp-8974	595	16	-	-	ADJ
fnp-8974	595	17	gc	gc	ADJ
fnp-8974	595	18	tumours	tumours	PROPN
fnp-8974	595	19	(	(	PUNCT
fnp-8974	595	20	e.g.	e.g.	ADV
fnp-8974	595	21	,	,	PUNCT
fnp-8974	595	22	46	46	NUM
fnp-8974	595	23	 	 	SPACE
fnp-8974	595	24	%	%	NOUN
fnp-8974	595	25	vs.	vs.	ADP
fnp-8974	595	26	28	28	NUM
fnp-8974	595	27	 	 	SPACE
fnp-8974	595	28	%	%	NOUN
fnp-8974	595	29	in	in	ADP
fnp-8974	595	30	gbm	gbm	NOUN
fnp-8974	595	31	)	)	PUNCT
fnp-8974	595	32	,	,	PUNCT
fnp-8974	595	33	whereas	whereas	SCONJ
fnp-8974	595	34	mgmt	mgmt	NOUN
fnp-8974	595	35	promoter	promoter	NOUN
fnp-8974	595	36	methylation	methylation	NOUN
fnp-8974	595	37	was	be	AUX
fnp-8974	595	38	uncommon	uncommon	ADJ
fnp-8974	595	39	in	in	ADP
fnp-8974	595	40	gclgs	gclgs	NOUN
fnp-8974	595	41	with	with	ADP
fnp-8974	595	42	gc	gc	PROPN
fnp-8974	595	43	growth	growth	NOUN
fnp-8974	595	44	pattern	pattern	NOUN
fnp-8974	595	45	(	(	PUNCT
fnp-8974	595	46	7	7	NUM
fnp-8974	595	47	 	 	SPACE
fnp-8974	595	48	%	%	NOUN
fnp-8974	595	49	vs.	vs.	ADP
fnp-8974	595	50	28	28	NUM
fnp-8974	595	51	 	 	SPACE
fnp-8974	595	52	%	%	NOUN
fnp-8974	595	53	,	,	PUNCT
fnp-8974	595	54	p	p	X
fnp-8974	595	55	 	 	SPACE
fnp-8974	595	56	<	<	X
fnp-8974	595	57	 	 	SPACE
fnp-8974	595	58	0.001	0.001	NUM
fnp-8974	595	59	)	)	PUNCT
fnp-8974	595	60	.	.	PUNCT
fnp-8974	596	1	idh	idh	NOUN
fnp-8974	596	2	-	-	PUNCT
fnp-8974	596	3	mutant	mutant	NOUN
fnp-8974	596	4	gliomas	glioma	NOUN
fnp-8974	596	5	with	with	ADP
fnp-8974	596	6	gc	gc	PROPN
fnp-8974	596	7	were	be	AUX
fnp-8974	596	8	more	more	ADV
fnp-8974	596	9	often	often	ADV
fnp-8974	596	10	treated	treat	VERB
fnp-8974	596	11	with	with	ADP
fnp-8974	596	12	radiotherapy	radiotherapy	NOUN
fnp-8974	596	13	or	or	CCONJ
fnp-8974	596	14	chemotherapy	chemotherapy	NOUN
fnp-8974	596	15	alone	alone	ADV
fnp-8974	596	16	.	.	PUNCT
fnp-8974	597	1	notably	notably	ADV
fnp-8974	597	2	,	,	PUNCT
fnp-8974	597	3	gbms	gbms	NOUN
fnp-8974	597	4	and	and	CCONJ
fnp-8974	597	5	gclgs	gclgs	NOUN
fnp-8974	597	6	with	with	ADP
fnp-8974	597	7	gc	gc	PROPN
fnp-8974	597	8	exhibited	exhibit	VERB
fnp-8974	597	9	comparable	comparable	ADJ
fnp-8974	597	10	radiochemotherapy	radiochemotherapy	NOUN
fnp-8974	597	11	rates	rate	NOUN
fnp-8974	597	12	(	(	PUNCT
fnp-8974	597	13	88	88	NUM
fnp-8974	597	14	 	 	SPACE
fnp-8974	597	15	%	%	NOUN
fnp-8974	597	16	vs.	vs.	ADP
fnp-8974	597	17	86	86	NUM
fnp-8974	597	18	 	 	SPACE
fnp-8974	597	19	%	%	NOUN
fnp-8974	597	20	)	)	PUNCT
fnp-8974	597	21	,	,	PUNCT
fnp-8974	597	22	while	while	SCONJ
fnp-8974	597	23	monotherapy	monotherapy	NOUN
fnp-8974	597	24	and	and	CCONJ
fnp-8974	597	25	watchful	watchful	ADJ
fnp-8974	597	26	waiting	waiting	NOUN
fnp-8974	597	27	were	be	AUX
fnp-8974	597	28	infrequently	infrequently	ADV
fnp-8974	597	29	employed	employ	VERB
fnp-8974	597	30	(	(	PUNCT
fnp-8974	597	31	0	0	NUM
fnp-8974	597	32	 	 	SPACE
fnp-8974	597	33	%	%	NOUN
fnp-8974	597	34	vs.	vs.	ADP
fnp-8974	597	35	7	7	NUM
fnp-8974	597	36	 	 	SPACE
fnp-8974	597	37	%	%	NOUN
fnp-8974	597	38	and	and	CCONJ
fnp-8974	597	39	12	12	NUM
fnp-8974	597	40	 	 	SPACE
fnp-8974	597	41	%	%	NOUN
fnp-8974	597	42	vs.	vs.	ADP
fnp-8974	597	43	7	7	NUM
fnp-8974	597	44	 	 	SPACE
fnp-8974	597	45	%	%	NOUN
fnp-8974	597	46	)	)	PUNCT
fnp-8974	597	47	.	.	PUNCT
fnp-8974	598	1	outcome	outcome	VERB
fnp-8974	598	2	for	for	ADP
fnp-8974	598	3	gclg	gclg	NOUN
fnp-8974	598	4	with	with	ADP
fnp-8974	598	5	gc	gc	PROPN
fnp-8974	598	6	was	be	AUX
fnp-8974	598	7	significantly	significantly	ADV
fnp-8974	598	8	better	well	ADV
fnp-8974	598	9	compared	compare	VERB
fnp-8974	598	10	to	to	ADP
fnp-8974	598	11	gbm	gbm	PROPN
fnp-8974	598	12	with	with	ADP
fnp-8974	598	13	gc	gc	PROPN
fnp-8974	598	14	(	(	PUNCT
fnp-8974	598	15	mpfs	mpf	VERB
fnp-8974	598	16	25	25	NUM
fnp-8974	598	17	vs	vs	ADP
fnp-8974	598	18	12	12	NUM
fnp-8974	598	19	months	month	NOUN
fnp-8974	598	20	,	,	PUNCT
fnp-8974	598	21	mos	mos	PROPN
fnp-8974	598	22	49	49	NUM
fnp-8974	598	23	vs	vs	ADP
fnp-8974	598	24	19	19	NUM
fnp-8974	598	25	months	month	NOUN
fnp-8974	598	26	,	,	PUNCT
fnp-8974	598	27	p	p	X
fnp-8974	598	28	 	 	SPACE
fnp-8974	598	29	<	<	X
fnp-8974	598	30	 	 	SPACE
fnp-8974	598	31	0.05	0.05	NUM
fnp-8974	598	32	)	)	PUNCT
fnp-8974	598	33	.	.	PUNCT
fnp-8974	599	1	in	in	ADP
fnp-8974	599	2	summary	summary	NOUN
fnp-8974	599	3	,	,	PUNCT
fnp-8974	599	4	while	while	SCONJ
fnp-8974	599	5	gc	gc	PROPN
fnp-8974	599	6	is	be	AUX
fnp-8974	599	7	uncommon	uncommon	ADJ
fnp-8974	599	8	in	in	ADP
fnp-8974	599	9	most	most	ADJ
fnp-8974	599	10	glioma	glioma	NOUN
fnp-8974	599	11	types	type	NOUN
fnp-8974	599	12	,	,	PUNCT
fnp-8974	599	13	it	it	PRON
fnp-8974	599	14	represents	represent	VERB
fnp-8974	599	15	the	the	DET
fnp-8974	599	16	predominant	predominant	ADJ
fnp-8974	599	17	growth	growth	NOUN
fnp-8974	599	18	pattern	pattern	NOUN
fnp-8974	599	19	in	in	ADP
fnp-8974	599	20	gclg	gclg	NOUN
fnp-8974	599	21	.	.	PUNCT
fnp-8974	600	1	despite	despite	SCONJ
fnp-8974	600	2	infrequent	infrequent	ADJ
fnp-8974	600	3	mgmt	mgmt	PROPN
fnp-8974	600	4	promoter	promoter	NOUN
fnp-8974	600	5	methylation	methylation	NOUN
fnp-8974	600	6	,	,	PUNCT
fnp-8974	600	7	the	the	DET
fnp-8974	600	8	prognosis	prognosis	NOUN
fnp-8974	600	9	of	of	ADP
fnp-8974	600	10	gclg	gclg	NOUN
fnp-8974	600	11	with	with	ADP
fnp-8974	600	12	gc	gc	PROPN
fnp-8974	600	13	is	be	AUX
fnp-8974	600	14	considerably	considerably	ADV
fnp-8974	600	15	more	more	ADV
fnp-8974	600	16	favourable	favourable	ADJ
fnp-8974	600	17	than	than	ADP
fnp-8974	600	18	gbm	gbm	PROPN
fnp-8974	600	19	.	.	PUNCT
fnp-8974	601	1	we	we	PRON
fnp-8974	601	2	therefore	therefore	ADV
fnp-8974	601	3	recommend	recommend	VERB
fnp-8974	601	4	comprehensive	comprehensive	ADJ
fnp-8974	601	5	epigenetic	epigenetic	ADJ
fnp-8974	601	6	profiling	profiling	NOUN
fnp-8974	601	7	in	in	ADP
fnp-8974	601	8	patients	patient	NOUN
fnp-8974	601	9	presenting	present	VERB
fnp-8974	601	10	radiologically	radiologically	ADV
fnp-8974	601	11	with	with	ADP
fnp-8974	601	12	gc	gc	PROPN
fnp-8974	601	13	type	type	NOUN
fnp-8974	601	14	1	1	NUM
fnp-8974	601	15	.	.	X
fnp-8974	601	16	p47	p47	PROPN
fnp-8974	601	17	free	free	ADJ
fnp-8974	601	18	neuropathol	neuropathol	NOUN
fnp-8974	601	19	6:17:69	6:17:69	NUM
fnp-8974	601	20	immunohistochemical	immunohistochemical	ADJ
fnp-8974	601	21	expression	expression	NOUN
fnp-8974	601	22	and	and	CCONJ
fnp-8974	601	23	differential	differential	ADJ
fnp-8974	601	24	methylation	methylation	NOUN
fnp-8974	601	25	of	of	ADP
fnp-8974	601	26	hoxb13	hoxb13	NOUN
fnp-8974	601	27	reliably	reliably	ADV
fnp-8974	601	28	distinguishes	distinguish	VERB
fnp-8974	601	29	myxopapillary	myxopapillary	ADJ
fnp-8974	601	30	ependymoma	ependymoma	NOUN
fnp-8974	601	31	from	from	ADP
fnp-8974	601	32	spinal	spinal	ADJ
fnp-8974	601	33	ependymoma	ependymoma	NOUN
fnp-8974	601	34	suvendu	suvendu	NOUN
fnp-8974	601	35	purkait1,2	purkait1,2	PROPN
fnp-8974	601	36	,	,	PUNCT
fnp-8974	601	37	sophia	sophia	PROPN
fnp-8974	601	38	praeger3,4	praeger3,4	PROPN
fnp-8974	601	39	,	,	PUNCT
fnp-8974	601	40	jörg	jörg	PROPN
fnp-8974	601	41	felsberg2	felsberg2	PROPN
fnp-8974	601	42	,	,	PUNCT
fnp-8974	601	43	david	david	PROPN
fnp-8974	601	44	pauck2	pauck2	PROPN
fnp-8974	601	45	,	,	PUNCT
fnp-8974	601	46	kerstin	kerstin	PROPN
fnp-8974	601	47	kaulich2,5	kaulich2,5	PROPN
fnp-8974	601	48	,	,	PUNCT
fnp-8974	601	49	marietta	marietta	PROPN
fnp-8974	601	50	wolter2	wolter2	PROPN
fnp-8974	601	51	,	,	PUNCT
fnp-8974	601	52	david	david	PROPN
fnp-8974	601	53	koppstein3,4	koppstein3,4	PROPN
fnp-8974	601	54	,	,	PUNCT
fnp-8974	601	55	guido	guido	NOUN
fnp-8974	601	56	reifenberger2,5	reifenberger2,5	PROPN
fnp-8974	601	57	1	1	NUM
fnp-8974	601	58	department	department	NOUN
fnp-8974	601	59	of	of	ADP
fnp-8974	601	60	pathology	pathology	NOUN
fnp-8974	601	61	and	and	CCONJ
fnp-8974	601	62	laboratory	laboratory	NOUN
fnp-8974	601	63	medicine	medicine	NOUN
fnp-8974	601	64	,	,	PUNCT
fnp-8974	601	65	all	all	DET
fnp-8974	601	66	india	india	PROPN
fnp-8974	601	67	institute	institute	PROPN
fnp-8974	601	68	of	of	ADP
fnp-8974	601	69	medical	medical	PROPN
fnp-8974	601	70	sciences	sciences	PROPN
fnp-8974	601	71	,	,	PUNCT
fnp-8974	601	72	bhubaneswar	bhubaneswar	NOUN
fnp-8974	601	73	,	,	PUNCT
fnp-8974	601	74	odisha	odisha	PROPN
fnp-8974	601	75	,	,	PUNCT
fnp-8974	601	76	india	india	PROPN
fnp-8974	601	77	2	2	NUM
fnp-8974	601	78	institute	institute	PROPN
fnp-8974	601	79	of	of	ADP
fnp-8974	601	80	neuropathology	neuropathology	NOUN
fnp-8974	601	81	,	,	PUNCT
fnp-8974	601	82	heinrich	heinrich	PROPN
fnp-8974	601	83	heine	heine	PROPN
fnp-8974	601	84	university	university	PROPN
fnp-8974	601	85	medical	medical	ADJ
fnp-8974	601	86	faculty	faculty	NOUN
fnp-8974	601	87	and	and	CCONJ
fnp-8974	601	88	university	university	NOUN
fnp-8974	601	89	hospital	hospital	NOUN
fnp-8974	601	90	düsseldorf	düsseldorf	PROPN
fnp-8974	601	91	,	,	PUNCT
fnp-8974	601	92	düsseldorf	düsseldorf	PROPN
fnp-8974	601	93	,	,	PUNCT
fnp-8974	601	94	germany	germany	PROPN
fnp-8974	601	95	3	3	NUM
fnp-8974	601	96	cancer	cancer	NOUN
fnp-8974	601	97	bioinformatics	bioinformatic	NOUN
fnp-8974	601	98	and	and	CCONJ
fnp-8974	601	99	multiomics	multiomics	NOUN
fnp-8974	601	100	(	(	PUNCT
fnp-8974	601	101	ed08	ed08	PROPN
fnp-8974	601	102	)	)	PUNCT
fnp-8974	601	103	,	,	PUNCT
fnp-8974	601	104	german	german	ADJ
fnp-8974	601	105	cancer	cancer	NOUN
fnp-8974	601	106	research	research	NOUN
fnp-8974	601	107	center	center	PROPN
fnp-8974	601	108	heidelberg	heidelberg	NOUN
fnp-8974	601	109	and	and	CCONJ
fnp-8974	601	110	german	german	ADJ
fnp-8974	601	111	cancer	cancer	NOUN
fnp-8974	601	112	consortium	consortium	NOUN
fnp-8974	601	113	(	(	PUNCT
fnp-8974	601	114	dktk	dktk	NOUN
fnp-8974	601	115	)	)	PUNCT
fnp-8974	601	116	,	,	PUNCT
fnp-8974	601	117	partner	partner	NOUN
fnp-8974	601	118	site	site	NOUN
fnp-8974	601	119	essen	essen	PROPN
fnp-8974	601	120	/	/	SYM
fnp-8974	601	121	düsseldorf	düsseldorf	PROPN
fnp-8974	601	122	,	,	PUNCT
fnp-8974	601	123	düsseldorf	düsseldorf	PROPN
fnp-8974	601	124	,	,	PUNCT
fnp-8974	601	125	germany	germany	PROPN
fnp-8974	601	126	4	4	NUM
fnp-8974	601	127	department	department	NOUN
fnp-8974	601	128	of	of	ADP
fnp-8974	601	129	pediatric	pediatric	ADJ
fnp-8974	601	130	oncology	oncology	NOUN
fnp-8974	601	131	,	,	PUNCT
fnp-8974	601	132	hematology	hematology	NOUN
fnp-8974	601	133	and	and	CCONJ
fnp-8974	601	134	clinical	clinical	ADJ
fnp-8974	601	135	immunology	immunology	NOUN
fnp-8974	601	136	,	,	PUNCT
fnp-8974	601	137	heinrich	heinrich	PROPN
fnp-8974	601	138	heine	heine	PROPN
fnp-8974	601	139	university	university	PROPN
fnp-8974	601	140	medical	medical	ADJ
fnp-8974	601	141	faculty	faculty	NOUN
fnp-8974	601	142	and	and	CCONJ
fnp-8974	601	143	university	university	NOUN
fnp-8974	601	144	hospital	hospital	NOUN
fnp-8974	601	145	düsseldorf	düsseldorf	PROPN
fnp-8974	601	146	,	,	PUNCT
fnp-8974	601	147	düsseldorf	düsseldorf	PROPN
fnp-8974	601	148	,	,	PUNCT
fnp-8974	601	149	germany	germany	PROPN
fnp-8974	601	150	5	5	NUM
fnp-8974	601	151	german	german	ADJ
fnp-8974	601	152	cancer	cancer	NOUN
fnp-8974	601	153	consortium	consortium	NOUN
fnp-8974	601	154	(	(	PUNCT
fnp-8974	601	155	dktk	dktk	NOUN
fnp-8974	601	156	)	)	PUNCT
fnp-8974	601	157	,	,	PUNCT
fnp-8974	601	158	partner	partner	NOUN
fnp-8974	601	159	site	site	NOUN
fnp-8974	601	160	essen	essen	PROPN
fnp-8974	601	161	/	/	SYM
fnp-8974	601	162	düsseldorf	düsseldorf	PROPN
fnp-8974	601	163	,	,	PUNCT
fnp-8974	601	164	düsseldorf	düsseldorf	PROPN
fnp-8974	601	165	,	,	PUNCT
fnp-8974	601	166	germany	germany	PROPN
fnp-8974	601	167	background	background	NOUN
fnp-8974	601	168	:	:	PUNCT
fnp-8974	601	169	histological	histological	ADJ
fnp-8974	601	170	distinction	distinction	NOUN
fnp-8974	601	171	of	of	ADP
fnp-8974	601	172	spinal	spinal	ADJ
fnp-8974	601	173	ependymoma	ependymoma	NOUN
fnp-8974	601	174	from	from	ADP
fnp-8974	601	175	myxopapillary	myxopapillary	ADJ
fnp-8974	601	176	ependymoma	ependymoma	NOUN
fnp-8974	601	177	may	may	AUX
fnp-8974	601	178	be	be	AUX
fnp-8974	601	179	difficult	difficult	ADJ
fnp-8974	601	180	in	in	ADP
fnp-8974	601	181	individual	individual	ADJ
fnp-8974	601	182	cases	case	NOUN
fnp-8974	601	183	,	,	PUNCT
fnp-8974	601	184	especially	especially	ADV
fnp-8974	601	185	in	in	ADP
fnp-8974	601	186	tumors	tumor	NOUN
fnp-8974	601	187	located	locate	VERB
fnp-8974	601	188	in	in	ADP
fnp-8974	601	189	the	the	DET
fnp-8974	601	190	lumbar	lumbar	NOUN
fnp-8974	601	191	region	region	NOUN
fnp-8974	601	192	.	.	PUNCT
fnp-8974	602	1	according	accord	VERB
fnp-8974	602	2	to	to	ADP
fnp-8974	602	3	the	the	DET
fnp-8974	602	4	who	who	PRON
fnp-8974	602	5	classification	classification	NOUN
fnp-8974	602	6	of	of	ADP
fnp-8974	602	7	2021	2021	NUM
fnp-8974	602	8	unresolved	unresolved	ADJ
fnp-8974	602	9	lesions	lesion	NOUN
fnp-8974	602	10	require	require	VERB
fnp-8974	602	11	global	global	ADJ
fnp-8974	602	12	dna	dna	PROPN
fnp-8974	602	13	methylation	methylation	NOUN
fnp-8974	602	14	profiling	profiling	NOUN
fnp-8974	602	15	for	for	ADP
fnp-8974	602	16	correct	correct	ADJ
fnp-8974	602	17	classification	classification	NOUN
fnp-8974	602	18	.	.	PUNCT
fnp-8974	603	1	recently	recently	ADV
fnp-8974	603	2	,	,	PUNCT
fnp-8974	603	3	high	high	ADJ
fnp-8974	603	4	expression	expression	NOUN
fnp-8974	603	5	of	of	ADP
fnp-8974	603	6	the	the	DET
fnp-8974	603	7	homeobox	homeobox	NOUN
fnp-8974	603	8	gene	gene	NOUN
fnp-8974	603	9	hoxb13	hoxb13	NOUN
fnp-8974	603	10	at	at	ADP
fnp-8974	603	11	the	the	DET
fnp-8974	603	12	mrna	mrna	PROPN
fnp-8974	603	13	and	and	CCONJ
fnp-8974	603	14	protein	protein	NOUN
fnp-8974	603	15	levels	level	NOUN
fnp-8974	603	16	has	have	AUX
fnp-8974	603	17	been	be	AUX
fnp-8974	603	18	reported	report	VERB
fnp-8974	603	19	in	in	ADP
fnp-8974	603	20	myxopapillary	myxopapillary	ADJ
fnp-8974	603	21	ependymoma	ependymoma	NOUN
fnp-8974	603	22	.	.	PUNCT
fnp-8974	604	1	objective(s	objective(s	NOUN
fnp-8974	604	2	):	):	PUNCT
fnp-8974	604	3	we	we	PRON
fnp-8974	604	4	evaluated	evaluate	VERB
fnp-8974	604	5	the	the	DET
fnp-8974	604	6	diagnostic	diagnostic	ADJ
fnp-8974	604	7	role	role	NOUN
fnp-8974	604	8	of	of	ADP
fnp-8974	604	9	hoxb13	hoxb13	NOUN
fnp-8974	604	10	immunostaining	immunostaine	VERB
fnp-8974	604	11	in	in	ADP
fnp-8974	604	12	an	an	DET
fnp-8974	604	13	institutional	institutional	ADJ
fnp-8974	604	14	cohort	cohort	NOUN
fnp-8974	604	15	of	of	ADP
fnp-8974	604	16	patients	patient	NOUN
fnp-8974	604	17	with	with	ADP
fnp-8974	604	18	spinal	spinal	ADJ
fnp-8974	604	19	neoplasms	neoplasm	NOUN
fnp-8974	604	20	(	(	PUNCT
fnp-8974	604	21	n	n	CCONJ
fnp-8974	604	22	 	 	SPACE
fnp-8974	604	23	=	=	NOUN
fnp-8974	604	24	 	 	SPACE
fnp-8974	604	25	143	143	NUM
fnp-8974	604	26	)	)	PUNCT
fnp-8974	604	27	,	,	PUNCT
fnp-8974	604	28	including	include	VERB
fnp-8974	604	29	different	different	ADJ
fnp-8974	604	30	types	type	NOUN
fnp-8974	604	31	of	of	ADP
fnp-8974	604	32	spinal	spinal	ADJ
fnp-8974	604	33	ependymal	ependymal	ADJ
fnp-8974	604	34	tumors	tumor	NOUN
fnp-8974	604	35	from	from	ADP
fnp-8974	604	36	various	various	ADJ
fnp-8974	604	37	locations	location	NOUN
fnp-8974	604	38	and	and	CCONJ
fnp-8974	604	39	other	other	ADJ
fnp-8974	604	40	relevant	relevant	ADJ
fnp-8974	604	41	differential	differential	NOUN
fnp-8974	604	42	diagnoses	diagnosis	NOUN
fnp-8974	604	43	.	.	PUNCT
fnp-8974	605	1	method(s	method(	VERB
fnp-8974	605	2	):	):	PUNCT
fnp-8974	605	3	expression	expression	NOUN
fnp-8974	605	4	of	of	ADP
fnp-8974	605	5	hoxb13	hoxb13	NOUN
fnp-8974	605	6	protein	protein	NOUN
fnp-8974	605	7	was	be	AUX
fnp-8974	605	8	compared	compare	VERB
fnp-8974	605	9	to	to	ADP
fnp-8974	605	10	molecular	molecular	ADJ
fnp-8974	605	11	findings	finding	NOUN
fnp-8974	605	12	obtained	obtain	VERB
fnp-8974	605	13	by	by	ADP
fnp-8974	605	14	dna	dna	PROPN
fnp-8974	605	15	methylation	methylation	NOUN
fnp-8974	605	16	profiling	profiling	NOUN
fnp-8974	605	17	,	,	PUNCT
fnp-8974	605	18	targeted	target	VERB
fnp-8974	605	19	methylation	methylation	NOUN
fnp-8974	605	20	analysis	analysis	NOUN
fnp-8974	605	21	,	,	PUNCT
fnp-8974	605	22	and	and	CCONJ
fnp-8974	605	23	next	next	ADJ
fnp-8974	605	24	generation	generation	NOUN
fnp-8974	605	25	sequencing	sequence	VERB
fnp-8974	605	26	.	.	PUNCT
fnp-8974	606	1	result(s	result(s	NOUN
fnp-8974	606	2	):	):	PUNCT
fnp-8974	606	3	collectively	collectively	ADV
fnp-8974	606	4	,	,	PUNCT
fnp-8974	606	5	our	our	PRON
fnp-8974	606	6	findings	finding	NOUN
fnp-8974	606	7	indicate	indicate	VERB
fnp-8974	606	8	that	that	SCONJ
fnp-8974	606	9	strong	strong	ADJ
fnp-8974	606	10	nuclear	nuclear	ADJ
fnp-8974	606	11	hoxb13	hoxb13	NOUN
fnp-8974	606	12	immunopositivity	immunopositivity	NOUN
fnp-8974	606	13	is	be	AUX
fnp-8974	606	14	a	a	DET
fnp-8974	606	15	specific	specific	ADJ
fnp-8974	606	16	diagnostic	diagnostic	ADJ
fnp-8974	606	17	marker	marker	NOUN
fnp-8974	606	18	for	for	ADP
fnp-8974	606	19	myxopapillary	myxopapillary	ADJ
fnp-8974	606	20	ependymoma	ependymoma	NOUN
fnp-8974	606	21	which	which	PRON
fnp-8974	606	22	enables	enable	VERB
fnp-8974	606	23	reliable	reliable	ADJ
fnp-8974	606	24	differentiation	differentiation	NOUN
fnp-8974	606	25	of	of	ADP
fnp-8974	606	26	spinal	spinal	ADJ
fnp-8974	606	27	ependymoma	ependymoma	NOUN
fnp-8974	606	28	,	,	PUNCT
fnp-8974	606	29	especially	especially	ADV
fnp-8974	606	30	in	in	ADP
fnp-8974	606	31	lumbar	lumbar	ADJ
fnp-8974	606	32	spinal	spinal	NOUN
fnp-8974	606	33	cord	cord	NOUN
fnp-8974	606	34	tumors	tumor	NOUN
fnp-8974	606	35	whose	whose	DET
fnp-8974	606	36	precise	precise	ADJ
fnp-8974	606	37	classification	classification	NOUN
fnp-8974	606	38	otherwise	otherwise	ADV
fnp-8974	606	39	would	would	AUX
fnp-8974	606	40	require	require	VERB
fnp-8974	606	41	dna	dna	PROPN
fnp-8974	606	42	methylation	methylation	NOUN
fnp-8974	606	43	profiling	profiling	NOUN
fnp-8974	606	44	.	.	PUNCT
fnp-8974	607	1	we	we	PRON
fnp-8974	607	2	additionally	additionally	ADV
fnp-8974	607	3	provide	provide	VERB
fnp-8974	607	4	evidence	evidence	NOUN
fnp-8974	607	5	for	for	ADP
fnp-8974	607	6	differential	differential	ADJ
fnp-8974	607	7	methylation	methylation	NOUN
fnp-8974	607	8	of	of	ADP
fnp-8974	607	9	hoxb13	hoxb13	NOUN
fnp-8974	607	10	-	-	PUNCT
fnp-8974	607	11	associated	associate	VERB
fnp-8974	607	12	cpg	cpg	NOUN
fnp-8974	607	13	sites	site	NOUN
fnp-8974	607	14	and	and	CCONJ
fnp-8974	607	15	established	establish	VERB
fnp-8974	607	16	a	a	DET
fnp-8974	607	17	pyrosequencing	pyrosequencing	NOUN
fnp-8974	607	18	-	-	PUNCT
fnp-8974	607	19	based	base	VERB
fnp-8974	607	20	assay	assay	NOUN
fnp-8974	607	21	to	to	PART
fnp-8974	607	22	interrogate	interrogate	VERB
fnp-8974	607	23	a	a	DET
fnp-8974	607	24	hoxb13	hoxb13	NOUN
fnp-8974	607	25	-	-	PUNCT
fnp-8974	607	26	associated	associate	VERB
fnp-8974	607	27	cpg	cpg	NOUN
fnp-8974	607	28	site	site	NOUN
fnp-8974	607	29	that	that	PRON
fnp-8974	607	30	showed	show	VERB
fnp-8974	607	31	consistent	consistent	ADJ
fnp-8974	607	32	differential	differential	ADJ
fnp-8974	607	33	methylation	methylation	NOUN
fnp-8974	607	34	between	between	ADP
fnp-8974	607	35	spinal	spinal	ADJ
fnp-8974	607	36	ependymoma	ependymoma	NOUN
fnp-8974	607	37	and	and	CCONJ
fnp-8974	607	38	myxopapillary	myxopapillary	ADJ
fnp-8974	607	39	ependymoma	ependymoma	NOUN
fnp-8974	607	40	.	.	PUNCT
fnp-8974	608	1	conclusion(s	conclusion(s	NOUN
fnp-8974	608	2	):	):	PUNCT
fnp-8974	608	3	thus	thus	ADV
fnp-8974	608	4	,	,	PUNCT
fnp-8974	608	5	immunohistochemistry	immunohistochemistry	NOUN
fnp-8974	608	6	for	for	ADP
fnp-8974	608	7	hoxb13	hoxb13	NOUN
fnp-8974	608	8	and/or	and/or	CCONJ
fnp-8974	608	9	targeted	target	VERB
fnp-8974	608	10	dna	dna	PROPN
fnp-8974	608	11	methylation	methylation	NOUN
fnp-8974	608	12	analysis	analysis	NOUN
fnp-8974	608	13	may	may	AUX
fnp-8974	608	14	constitute	constitute	VERB
fnp-8974	608	15	fast	fast	ADJ
fnp-8974	608	16	,	,	PUNCT
fnp-8974	608	17	resource	resource	NOUN
fnp-8974	608	18	-	-	PUNCT
fnp-8974	608	19	friendly	friendly	ADJ
fnp-8974	608	20	approaches	approach	NOUN
fnp-8974	608	21	to	to	PART
fnp-8974	608	22	substitute	substitute	VERB
fnp-8974	608	23	for	for	ADP
fnp-8974	608	24	global	global	ADJ
fnp-8974	608	25	dna	dna	PROPN
fnp-8974	608	26	methylation	methylation	NOUN
fnp-8974	608	27	profiling	profiling	NOUN
fnp-8974	608	28	in	in	ADP
fnp-8974	608	29	the	the	DET
fnp-8974	608	30	precise	precise	ADJ
fnp-8974	608	31	classification	classification	NOUN
fnp-8974	608	32	of	of	ADP
fnp-8974	608	33	spinal	spinal	ADJ
fnp-8974	608	34	ependymal	ependymal	ADJ
fnp-8974	608	35	tumors	tumor	NOUN
fnp-8974	608	36	.	.	PUNCT
fnp-8974	609	1	p48	p48	NOUN
fnp-8974	609	2	free	free	ADJ
fnp-8974	609	3	neuropathol	neuropathol	NOUN
fnp-8974	609	4	6:17:71	6:17:71	NUM
fnp-8974	609	5	spatial	spatial	ADJ
fnp-8974	609	6	mapping	mapping	NOUN
fnp-8974	609	7	of	of	ADP
fnp-8974	609	8	immunogenic	immunogenic	ADJ
fnp-8974	609	9	niches	niche	NOUN
fnp-8974	609	10	in	in	ADP
fnp-8974	609	11	melanoma	melanoma	NOUN
fnp-8974	609	12	brain	brain	NOUN
fnp-8974	609	13	metastases	metastasis	NOUN
fnp-8974	609	14	kristin	kristin	PROPN
fnp-8974	609	15	peters1	peters1	NOUN
fnp-8974	609	16	,	,	PUNCT
fnp-8974	609	17	artür	artür	PROPN
fnp-8974	609	18	manukyan2	manukyan2	PROPN
fnp-8974	609	19	,	,	PUNCT
fnp-8974	609	20	helena	helena	PROPN
fnp-8974	609	21	radbruch3	radbruch3	PROPN
fnp-8974	609	22	,	,	PUNCT
fnp-8974	609	23	torben	torben	PROPN
fnp-8974	609	24	redmer4	redmer4	PROPN
fnp-8974	609	25	,	,	PUNCT
fnp-8974	609	26	josefine	josefine	PROPN
fnp-8974	609	27	radke4	radke4	PROPN
fnp-8974	609	28	1	1	NUM
fnp-8974	609	29	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	609	30	greifswald	greifswald	PROPN
fnp-8974	609	31	,	,	PUNCT
fnp-8974	609	32	institut	institut	PROPN
fnp-8974	609	33	für	für	PROPN
fnp-8974	609	34	pathologie	pathologie	PROPN
fnp-8974	609	35	,	,	PUNCT
fnp-8974	609	36	greifswald	greifswald	PROPN
fnp-8974	609	37	,	,	PUNCT
fnp-8974	609	38	germany	germany	PROPN
fnp-8974	609	39	2	2	NUM
fnp-8974	609	40	berliner	berliner	PROPN
fnp-8974	609	41	institut	institut	PROPN
fnp-8974	609	42	für	für	PROPN
fnp-8974	609	43	medizinische	medizinische	PROPN
fnp-8974	609	44	systembiologie	systembiologie	NOUN
fnp-8974	609	45	(	(	PUNCT
fnp-8974	609	46	mdc	mdc	NOUN
fnp-8974	609	47	-	-	PUNCT
fnp-8974	609	48	bimsb	bimsb	NOUN
fnp-8974	609	49	)	)	PUNCT
fnp-8974	609	50	,	,	PUNCT
fnp-8974	609	51	berlin	berlin	PROPN
fnp-8974	609	52	,	,	PUNCT
fnp-8974	609	53	germany	germany	PROPN
fnp-8974	609	54	3	3	NUM
fnp-8974	609	55	charité	charité	PROPN
fnp-8974	609	56	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	609	57	berlin	berlin	PROPN
fnp-8974	609	58	,	,	PUNCT
fnp-8974	609	59	institut	institut	PROPN
fnp-8974	609	60	für	für	PROPN
fnp-8974	609	61	neuropathologie	neuropathologie	PROPN
fnp-8974	609	62	,	,	PUNCT
fnp-8974	609	63	berlin	berlin	PROPN
fnp-8974	609	64	,	,	PUNCT
fnp-8974	609	65	germany	germany	PROPN
fnp-8974	609	66	4	4	NUM
fnp-8974	609	67	universitätsmedizin	universitätsmedizin	PROPN
fnp-8974	609	68	greifswald	greifswald	PROPN
fnp-8974	609	69	,	,	PUNCT
fnp-8974	609	70	institut	institut	PROPN
fnp-8974	609	71	für	für	VERB
fnp-8974	609	72	molecular	molecular	ADJ
fnp-8974	609	73	genomics	genomic	NOUN
fnp-8974	609	74	,	,	PUNCT
fnp-8974	609	75	greifswald	greifswald	PROPN
fnp-8974	609	76	,	,	PUNCT
fnp-8974	609	77	germany	germany	PROPN
fnp-8974	609	78	background	background	NOUN
fnp-8974	609	79	:	:	PUNCT
fnp-8974	609	80	tumor	tumor	NOUN
fnp-8974	609	81	development	development	NOUN
fnp-8974	609	82	and	and	CCONJ
fnp-8974	609	83	progression	progression	NOUN
fnp-8974	609	84	are	be	AUX
fnp-8974	609	85	dynamic	dynamic	ADJ
fnp-8974	609	86	,	,	PUNCT
fnp-8974	609	87	time	time	NOUN
fnp-8974	609	88	-	-	PUNCT
fnp-8974	609	89	dependent	dependent	ADJ
fnp-8974	609	90	processes	process	NOUN
fnp-8974	609	91	influenced	influence	VERB
fnp-8974	609	92	by	by	ADP
fnp-8974	609	93	genetic	genetic	ADJ
fnp-8974	609	94	alterations	alteration	NOUN
fnp-8974	609	95	,	,	PUNCT
fnp-8974	609	96	environmental	environmental	ADJ
fnp-8974	609	97	factors	factor	NOUN
fnp-8974	609	98	,	,	PUNCT
fnp-8974	609	99	and	and	CCONJ
fnp-8974	609	100	spatial	spatial	ADJ
fnp-8974	609	101	mechanisms	mechanism	NOUN
fnp-8974	609	102	all	all	PRON
fnp-8974	609	103	shaped	shape	VERB
fnp-8974	609	104	by	by	ADP
fnp-8974	609	105	interactions	interaction	NOUN
fnp-8974	609	106	with	with	ADP
fnp-8974	609	107	the	the	DET
fnp-8974	609	108	tumor	tumor	NOUN
fnp-8974	609	109	microenvironment	microenvironment	NOUN
fnp-8974	609	110	(	(	PUNCT
fnp-8974	609	111	tme	tme	PROPN
fnp-8974	609	112	)	)	PUNCT
fnp-8974	609	113	.	.	PUNCT
fnp-8974	610	1	resistance	resistance	NOUN
fnp-8974	610	2	to	to	ADP
fnp-8974	610	3	immune	immune	ADJ
fnp-8974	610	4	checkpoint	checkpoint	NOUN
fnp-8974	610	5	inhibition	inhibition	NOUN
fnp-8974	610	6	(	(	PUNCT
fnp-8974	610	7	ici	ici	NOUN
fnp-8974	610	8	)	)	PUNCT
fnp-8974	610	9	significantly	significantly	ADV
fnp-8974	610	10	contributes	contribute	VERB
fnp-8974	610	11	to	to	ADP
fnp-8974	610	12	the	the	DET
fnp-8974	610	13	emergence	emergence	NOUN
fnp-8974	610	14	and	and	CCONJ
fnp-8974	610	15	metastatic	metastatic	ADJ
fnp-8974	610	16	progression	progression	NOUN
fnp-8974	610	17	of	of	ADP
fnp-8974	610	18	brain	brain	NOUN
fnp-8974	610	19	metastases	metastasis	NOUN
fnp-8974	610	20	(	(	PUNCT
fnp-8974	610	21	mbm	mbm	PROPN
fnp-8974	610	22	)	)	PUNCT
fnp-8974	610	23	in	in	ADP
fnp-8974	610	24	approximately	approximately	ADV
fnp-8974	610	25	40–60	40–60	NOUN
fnp-8974	610	26	 	 	SPACE
fnp-8974	610	27	%	%	NOUN
fnp-8974	610	28	of	of	ADP
fnp-8974	610	29	melanoma	melanoma	NOUN
fnp-8974	610	30	patients	patient	NOUN
fnp-8974	610	31	.	.	PUNCT
fnp-8974	611	1	objective(s	objective(s	NOUN
fnp-8974	611	2	):	):	PUNCT
fnp-8974	611	3	we	we	PRON
fnp-8974	611	4	employed	employ	VERB
fnp-8974	611	5	spatial	spatial	ADJ
fnp-8974	611	6	transcriptomics	transcriptomic	NOUN
fnp-8974	611	7	at	at	ADP
fnp-8974	611	8	the	the	DET
fnp-8974	611	9	single	single	ADJ
fnp-8974	611	10	cell	cell	NOUN
fnp-8974	611	11	level	level	NOUN
fnp-8974	611	12	to	to	PART
fnp-8974	611	13	investigate	investigate	VERB
fnp-8974	611	14	spatially	spatially	ADV
fnp-8974	611	15	defined	define	VERB
fnp-8974	611	16	immunosuppressive	immunosuppressive	ADJ
fnp-8974	611	17	programmes	programme	NOUN
fnp-8974	611	18	in	in	ADP
fnp-8974	611	19	mbm	mbm	PROPN
fnp-8974	611	20	and	and	CCONJ
fnp-8974	611	21	their	their	PRON
fnp-8974	611	22	role	role	NOUN
fnp-8974	611	23	in	in	ADP
fnp-8974	611	24	therapy	therapy	NOUN
fnp-8974	611	25	resistance	resistance	NOUN
fnp-8974	611	26	.	.	PUNCT
fnp-8974	612	1	question(s	question(s	PROPN
fnp-8974	612	2	):	):	PUNCT
fnp-8974	612	3	what	what	PRON
fnp-8974	612	4	are	be	AUX
fnp-8974	612	5	the	the	DET
fnp-8974	612	6	spatial	spatial	ADJ
fnp-8974	612	7	characteristics	characteristic	NOUN
fnp-8974	612	8	and	and	CCONJ
fnp-8974	612	9	cellular	cellular	ADJ
fnp-8974	612	10	compositions	composition	NOUN
fnp-8974	612	11	of	of	ADP
fnp-8974	612	12	immune	immune	ADJ
fnp-8974	612	13	-	-	PUNCT
fnp-8974	612	14	suppressive	suppressive	NOUN
fnp-8974	612	15	niches	niche	NOUN
fnp-8974	612	16	in	in	ADP
fnp-8974	612	17	mbm	mbm	PROPN
fnp-8974	612	18	,	,	PUNCT
fnp-8974	612	19	and	and	CCONJ
fnp-8974	612	20	how	how	SCONJ
fnp-8974	612	21	do	do	AUX
fnp-8974	612	22	they	they	PRON
fnp-8974	612	23	relate	relate	VERB
fnp-8974	612	24	to	to	ADP
fnp-8974	612	25	resistance	resistance	NOUN
fnp-8974	612	26	against	against	ADP
fnp-8974	612	27	immune	immune	ADJ
fnp-8974	612	28	checkpoint	checkpoint	NOUN
fnp-8974	612	29	inhibition	inhibition	NOUN
fnp-8974	612	30	?	?	PUNCT
fnp-8974	613	1	method(s	method(	VERB
fnp-8974	613	2	):	):	PUNCT
fnp-8974	613	3	we	we	PRON
fnp-8974	613	4	applied	apply	VERB
fnp-8974	613	5	xenium	xenium	NOUN
fnp-8974	613	6	(	(	PUNCT
fnp-8974	613	7	10x	10x	NUM
fnp-8974	613	8	genomics	genomics	NOUN
fnp-8974	613	9	)	)	PUNCT
fnp-8974	613	10	spatial	spatial	ADJ
fnp-8974	613	11	transcriptomic	transcriptomic	ADJ
fnp-8974	613	12	technology	technology	NOUN
fnp-8974	613	13	to	to	ADP
fnp-8974	613	14	14	14	NUM
fnp-8974	613	15	mbm	mbm	NOUN
fnp-8974	613	16	specimens	specimen	NOUN
fnp-8974	613	17	representing	represent	VERB
fnp-8974	613	18	various	various	ADJ
fnp-8974	613	19	stages	stage	NOUN
fnp-8974	613	20	of	of	ADP
fnp-8974	613	21	tumor	tumor	NOUN
fnp-8974	613	22	progression	progression	NOUN
fnp-8974	613	23	and	and	CCONJ
fnp-8974	613	24	treatment	treatment	NOUN
fnp-8974	613	25	history	history	NOUN
fnp-8974	613	26	.	.	PUNCT
fnp-8974	614	1	single	single	ADJ
fnp-8974	614	2	-	-	PUNCT
fnp-8974	614	3	cell	cell	NOUN
fnp-8974	614	4	resolution	resolution	NOUN
fnp-8974	614	5	data	datum	NOUN
fnp-8974	614	6	were	be	AUX
fnp-8974	614	7	analyzed	analyze	VERB
fnp-8974	614	8	to	to	PART
fnp-8974	614	9	deconvolute	deconvolute	VERB
fnp-8974	614	10	the	the	DET
fnp-8974	614	11	immunogenic	immunogenic	ADJ
fnp-8974	614	12	landscape	landscape	NOUN
fnp-8974	614	13	and	and	CCONJ
fnp-8974	614	14	cellular	cellular	ADJ
fnp-8974	614	15	phenotypes	phenotype	NOUN
fnp-8974	614	16	within	within	ADP
fnp-8974	614	17	the	the	DET
fnp-8974	614	18	tumor	tumor	NOUN
fnp-8974	614	19	microenvironment	microenvironment	NOUN
fnp-8974	614	20	.	.	PUNCT
fnp-8974	615	1	result(s	result(s	PROPN
fnp-8974	615	2	):	):	PUNCT
fnp-8974	615	3	we	we	PRON
fnp-8974	615	4	identified	identify	VERB
fnp-8974	615	5	substantial	substantial	ADJ
fnp-8974	615	6	cellular	cellular	ADJ
fnp-8974	615	7	heterogeneity	heterogeneity	NOUN
fnp-8974	615	8	across	across	ADP
fnp-8974	615	9	mbm	mbm	NOUN
fnp-8974	615	10	samples	sample	NOUN
fnp-8974	615	11	and	and	CCONJ
fnp-8974	615	12	highlighted	highlight	VERB
fnp-8974	615	13	tumor	tumor	NOUN
fnp-8974	615	14	subsets	subset	NOUN
fnp-8974	615	15	expressing	express	VERB
fnp-8974	615	16	bzw2	bzw2	PROPN
fnp-8974	615	17	,	,	PUNCT
fnp-8974	615	18	sox4	sox4	NOUN
fnp-8974	615	19	,	,	PUNCT
fnp-8974	615	20	or	or	CCONJ
fnp-8974	615	21	tap1	tap1	PROPN
fnp-8974	615	22	.	.	PUNCT
fnp-8974	616	1	bzw2⁺	bzw2⁺	PROPN
fnp-8974	616	2	and	and	CCONJ
fnp-8974	616	3	sox4⁺	sox4⁺	ADJ
fnp-8974	616	4	tumor	tumor	NOUN
fnp-8974	616	5	cells	cell	NOUN
fnp-8974	616	6	were	be	AUX
fnp-8974	616	7	associated	associate	VERB
fnp-8974	616	8	with	with	ADP
fnp-8974	616	9	immune	immune	ADJ
fnp-8974	616	10	-	-	PUNCT
fnp-8974	616	11	suppressive	suppressive	ADJ
fnp-8974	616	12	microenvironments	microenvironment	NOUN
fnp-8974	616	13	characterized	characterize	VERB
fnp-8974	616	14	by	by	ADP
fnp-8974	616	15	poor	poor	ADJ
fnp-8974	616	16	infiltration	infiltration	NOUN
fnp-8974	616	17	of	of	ADP
fnp-8974	616	18	immune	immune	ADJ
fnp-8974	616	19	cells	cell	NOUN
fnp-8974	616	20	and	and	CCONJ
fnp-8974	616	21	tumor	tumor	NOUN
fnp-8974	616	22	-	-	PUNCT
fnp-8974	616	23	associated	associate	VERB
fnp-8974	616	24	macrophages	macrophage	NOUN
fnp-8974	616	25	/	/	SYM
fnp-8974	616	26	microglia	microglia	NOUN
fnp-8974	616	27	(	(	PUNCT
fnp-8974	616	28	tams	tam	NOUN
fnp-8974	616	29	)	)	PUNCT
fnp-8974	616	30	.	.	PUNCT
fnp-8974	617	1	bzw2	bzw2	PROPN
fnp-8974	617	2	and	and	CCONJ
fnp-8974	617	3	tap1	tap1	PROPN
fnp-8974	617	4	expression	expression	NOUN
fnp-8974	617	5	showed	show	VERB
fnp-8974	617	6	an	an	DET
fnp-8974	617	7	inverse	inverse	NOUN
fnp-8974	617	8	correlation	correlation	NOUN
fnp-8974	617	9	,	,	PUNCT
fnp-8974	617	10	with	with	ADP
fnp-8974	617	11	tap1	tap1	PROPN
fnp-8974	617	12	being	be	AUX
fnp-8974	617	13	enriched	enrich	VERB
fnp-8974	617	14	in	in	ADP
fnp-8974	617	15	"	"	PUNCT
fnp-8974	617	16	hot	hot	ADJ
fnp-8974	617	17	"	"	PUNCT
fnp-8974	617	18	immune	immune	ADJ
fnp-8974	617	19	cell	cell	NOUN
fnp-8974	617	20	–	–	PUNCT
fnp-8974	617	21	infiltrated	infiltrate	VERB
fnp-8974	617	22	niches	niche	NOUN
fnp-8974	617	23	,	,	PUNCT
fnp-8974	617	24	consistent	consistent	ADJ
fnp-8974	617	25	across	across	ADP
fnp-8974	617	26	tumor	tumor	NOUN
fnp-8974	617	27	stages	stage	NOUN
fnp-8974	617	28	.	.	PUNCT
fnp-8974	618	1	conclusion(s	conclusion(s	NOUN
fnp-8974	618	2	):	):	PUNCT
fnp-8974	618	3	spatially	spatially	ADV
fnp-8974	618	4	-	-	PUNCT
fnp-8974	618	5	defined	define	VERB
fnp-8974	618	6	immunosuppressive	immunosuppressive	ADJ
fnp-8974	618	7	programs	program	NOUN
fnp-8974	618	8	critically	critically	ADV
fnp-8974	618	9	shape	shape	VERB
fnp-8974	618	10	immune	immune	ADJ
fnp-8974	618	11	cell	cell	NOUN
fnp-8974	618	12	infiltration	infiltration	NOUN
fnp-8974	618	13	patterns	pattern	NOUN
fnp-8974	618	14	in	in	ADP
fnp-8974	618	15	mbm	mbm	PROPN
fnp-8974	618	16	and	and	CCONJ
fnp-8974	618	17	may	may	AUX
fnp-8974	618	18	influence	influence	VERB
fnp-8974	618	19	the	the	DET
fnp-8974	618	20	response	response	NOUN
fnp-8974	618	21	to	to	ADP
fnp-8974	618	22	immune	immune	ADJ
fnp-8974	618	23	checkpoint	checkpoint	NOUN
fnp-8974	618	24	therapies	therapy	NOUN
fnp-8974	618	25	.	.	PUNCT
fnp-8974	619	1	understanding	understand	VERB
fnp-8974	619	2	these	these	DET
fnp-8974	619	3	spatial	spatial	ADJ
fnp-8974	619	4	dynamics	dynamic	NOUN
fnp-8974	619	5	could	could	AUX
fnp-8974	619	6	inform	inform	VERB
fnp-8974	619	7	targeted	target	VERB
fnp-8974	619	8	therapeutic	therapeutic	ADJ
fnp-8974	619	9	strategies	strategy	NOUN
fnp-8974	619	10	to	to	PART
fnp-8974	619	11	overcome	overcome	VERB
fnp-8974	619	12	ici	ici	NOUN
fnp-8974	619	13	resistance	resistance	NOUN
fnp-8974	619	14	.	.	PUNCT
fnp-8974	620	1	p49	p49	PROPN
fnp-8974	620	2	free	free	ADJ
fnp-8974	620	3	neuropathol	neuropathol	NOUN
fnp-8974	620	4	6:17:72	6:17:72	NUM
fnp-8974	620	5	targeting	targeting	NOUN
fnp-8974	620	6	phosphorylation	phosphorylation	NOUN
fnp-8974	620	7	events	event	NOUN
fnp-8974	620	8	in	in	ADP
fnp-8974	620	9	glioblastoma	glioblastoma	NOUN
fnp-8974	620	10	:	:	PUNCT
fnp-8974	620	11	a	a	DET
fnp-8974	620	12	semi	semi	ADJ
fnp-8974	620	13	-	-	ADJ
fnp-8974	620	14	spatial	spatial	ADJ
fnp-8974	620	15	(	(	PUNCT
fnp-8974	620	16	phospho)proteomic	phospho)proteomic	ADJ
fnp-8974	620	17	workflow	workflow	NOUN
fnp-8974	620	18	for	for	ADP
fnp-8974	620	19	diffuse	diffuse	ADJ
fnp-8974	620	20	glioma	glioma	NOUN
fnp-8974	620	21	ffpe	ffpe	NOUN
fnp-8974	620	22	samples	sample	NOUN
fnp-8974	620	23	ivan	ivan	PROPN
fnp-8974	620	24	abdulrazak	abdulrazak	PROPN
fnp-8974	620	25	ahmed1,2	ahmed1,2	PROPN
fnp-8974	620	26	,	,	PUNCT
fnp-8974	620	27	gianluca	gianluca	PROPN
fnp-8974	620	28	sigismondo1	sigismondo1	PROPN
fnp-8974	620	29	,	,	PUNCT
fnp-8974	620	30	fuat	fuat	PROPN
fnp-8974	620	31	aras2	aras2	PROPN
fnp-8974	620	32	,	,	PUNCT
fnp-8974	620	33	david	david	PROPN
fnp-8974	620	34	reuss1	reuss1	PROPN
fnp-8974	620	35	,	,	PUNCT
fnp-8974	620	36	stefan	stefan	PROPN
fnp-8974	620	37	pusch1	pusch1	PROPN
fnp-8974	620	38	1	1	NUM
fnp-8974	620	39	universitätsklinikum	universitätsklinikum	NOUN
fnp-8974	620	40	heidelberg	heidelberg	NOUN
fnp-8974	620	41	,	,	PUNCT
fnp-8974	620	42	deutsches	deutsches	PROPN
fnp-8974	620	43	krebsforschungszentrum	krebsforschungszentrum	PROPN
fnp-8974	620	44	,	,	PUNCT
fnp-8974	620	45	heidelberg	heidelberg	PROPN
fnp-8974	620	46	,	,	PUNCT
fnp-8974	620	47	germany	germany	PROPN
fnp-8974	620	48	2	2	NUM
fnp-8974	620	49	universitätsklinikum	universitätsklinikum	NOUN
fnp-8974	620	50	heidelberg	heidelberg	PROPN
fnp-8974	620	51	,	,	PUNCT
fnp-8974	620	52	heidelberg	heidelberg	PROPN
fnp-8974	620	53	,	,	PUNCT
fnp-8974	620	54	germany	germany	PROPN
fnp-8974	620	55	glioblastoma	glioblastoma	NOUN
fnp-8974	620	56	is	be	AUX
fnp-8974	620	57	the	the	DET
fnp-8974	620	58	most	most	ADV
fnp-8974	620	59	frequent	frequent	ADJ
fnp-8974	620	60	and	and	CCONJ
fnp-8974	620	61	aggressive	aggressive	ADJ
fnp-8974	620	62	among	among	ADP
fnp-8974	620	63	the	the	DET
fnp-8974	620	64	glioma	glioma	NOUN
fnp-8974	620	65	.	.	PUNCT
fnp-8974	621	1	despite	despite	SCONJ
fnp-8974	621	2	dna	dna	PROPN
fnp-8974	621	3	methylation	methylation	NOUN
fnp-8974	621	4	has	have	AUX
fnp-8974	621	5	improved	improve	VERB
fnp-8974	621	6	tumor	tumor	NOUN
fnp-8974	621	7	classification	classification	NOUN
fnp-8974	621	8	,	,	PUNCT
fnp-8974	621	9	and	and	CCONJ
fnp-8974	621	10	dissected	dissect	VERB
fnp-8974	621	11	different	different	ADJ
fnp-8974	621	12	subtypes	subtype	NOUN
fnp-8974	621	13	,	,	PUNCT
fnp-8974	621	14	glioblastoma	glioblastoma	NOUN
fnp-8974	621	15	is	be	AUX
fnp-8974	621	16	still	still	ADV
fnp-8974	621	17	characterized	characterize	VERB
fnp-8974	621	18	by	by	ADP
fnp-8974	621	19	traditional	traditional	ADJ
fnp-8974	621	20	therapeutic	therapeutic	ADJ
fnp-8974	621	21	options	option	NOUN
fnp-8974	621	22	,	,	PUNCT
fnp-8974	621	23	resulting	result	VERB
fnp-8974	621	24	in	in	ADP
fnp-8974	621	25	poor	poor	ADJ
fnp-8974	621	26	patient	patient	ADJ
fnp-8974	621	27	response	response	NOUN
fnp-8974	621	28	and	and	CCONJ
fnp-8974	621	29	median	median	ADJ
fnp-8974	621	30	18	18	NUM
fnp-8974	621	31	months	month	NOUN
fnp-8974	621	32	survival	survival	NOUN
fnp-8974	621	33	.	.	PUNCT
fnp-8974	622	1	egfr	egfr	PROPN
fnp-8974	622	2	kinase	kinase	PROPN
fnp-8974	622	3	amplification	amplification	NOUN
fnp-8974	622	4	is	be	AUX
fnp-8974	622	5	observed	observe	VERB
fnp-8974	622	6	in	in	ADP
fnp-8974	622	7	60	60	NUM
fnp-8974	622	8	 	 	SPACE
fnp-8974	622	9	%	%	NOUN
fnp-8974	622	10	of	of	ADP
fnp-8974	622	11	glioblastoma	glioblastoma	NOUN
fnp-8974	622	12	,	,	PUNCT
fnp-8974	622	13	causing	cause	VERB
fnp-8974	622	14	hyperactivation	hyperactivation	NOUN
fnp-8974	622	15	of	of	ADP
fnp-8974	622	16	key	key	ADJ
fnp-8974	622	17	signaling	signal	VERB
fnp-8974	622	18	pathways	pathway	NOUN
fnp-8974	622	19	regulating	regulate	VERB
fnp-8974	622	20	proliferation	proliferation	NOUN
fnp-8974	622	21	,	,	PUNCT
fnp-8974	622	22	motility	motility	NOUN
fnp-8974	622	23	,	,	PUNCT
fnp-8974	622	24	and	and	CCONJ
fnp-8974	622	25	apoptosis	apoptosis	NOUN
fnp-8974	622	26	,	,	PUNCT
fnp-8974	622	27	thereby	thereby	ADV
fnp-8974	622	28	contributing	contribute	VERB
fnp-8974	622	29	to	to	ADP
fnp-8974	622	30	cancer	cancer	NOUN
fnp-8974	622	31	progression	progression	NOUN
fnp-8974	622	32	.	.	PUNCT
fnp-8974	623	1	in	in	ADP
fnp-8974	623	2	a	a	DET
fnp-8974	623	3	fraction	fraction	NOUN
fnp-8974	623	4	of	of	ADP
fnp-8974	623	5	patient	patient	NOUN
fnp-8974	623	6	,	,	PUNCT
fnp-8974	623	7	egfr	egfr	ADJ
fnp-8974	623	8	activation	activation	NOUN
fnp-8974	623	9	is	be	AUX
fnp-8974	623	10	observed	observe	VERB
fnp-8974	623	11	in	in	ADP
fnp-8974	623	12	the	the	DET
fnp-8974	623	13	absence	absence	NOUN
fnp-8974	623	14	of	of	ADP
fnp-8974	623	15	egfr	egfr	ADJ
fnp-8974	623	16	amplification	amplification	NOUN
fnp-8974	623	17	,	,	PUNCT
fnp-8974	623	18	thus	thus	ADV
fnp-8974	623	19	the	the	DET
fnp-8974	623	20	dissection	dissection	NOUN
fnp-8974	623	21	of	of	ADP
fnp-8974	623	22	egfr	egfr	ADJ
fnp-8974	623	23	phosphorylation	phosphorylation	NOUN
fnp-8974	623	24	cascade	cascade	NOUN
fnp-8974	623	25	is	be	AUX
fnp-8974	623	26	critical	critical	ADJ
fnp-8974	623	27	to	to	PART
fnp-8974	623	28	characterize	characterize	VERB
fnp-8974	623	29	gbm	gbm	NOUN
fnp-8974	623	30	biology	biology	NOUN
fnp-8974	623	31	.	.	PUNCT
fnp-8974	624	1	phosphorylation	phosphorylation	NOUN
fnp-8974	624	2	events	event	NOUN
fnp-8974	624	3	are	be	AUX
fnp-8974	624	4	dynamic	dynamic	ADJ
fnp-8974	624	5	,	,	PUNCT
fnp-8974	624	6	and	and	CCONJ
fnp-8974	624	7	due	due	ADP
fnp-8974	624	8	to	to	ADP
fnp-8974	624	9	the	the	DET
fnp-8974	624	10	very	very	ADV
fnp-8974	624	11	low	low	ADJ
fnp-8974	624	12	abundance	abundance	NOUN
fnp-8974	624	13	of	of	ADP
fnp-8974	624	14	phosphopeptides	phosphopeptide	NOUN
fnp-8974	624	15	,	,	PUNCT
fnp-8974	624	16	phosphoproteomic	phosphoproteomic	ADJ
fnp-8974	624	17	analysis	analysis	NOUN
fnp-8974	624	18	is	be	AUX
fnp-8974	624	19	particularly	particularly	ADV
fnp-8974	624	20	challenging	challenging	ADJ
fnp-8974	624	21	,	,	PUNCT
fnp-8974	624	22	especially	especially	ADV
fnp-8974	624	23	in	in	ADP
fnp-8974	624	24	formalin	formalin	NOUN
fnp-8974	624	25	-	-	PUNCT
fnp-8974	624	26	fixed	fix	VERB
fnp-8974	624	27	paraffin	paraffin	NOUN
fnp-8974	624	28	-	-	PUNCT
fnp-8974	624	29	embedded	embed	VERB
fnp-8974	624	30	(	(	PUNCT
fnp-8974	624	31	ffpe	ffpe	NOUN
fnp-8974	624	32	)	)	PUNCT
fnp-8974	624	33	clinical	clinical	ADJ
fnp-8974	624	34	tissues	tissue	NOUN
fnp-8974	624	35	.	.	PUNCT
fnp-8974	625	1	overcoming	overcome	VERB
fnp-8974	625	2	these	these	DET
fnp-8974	625	3	obstacles	obstacle	NOUN
fnp-8974	625	4	relies	rely	VERB
fnp-8974	625	5	on	on	ADP
fnp-8974	625	6	robust	robust	ADJ
fnp-8974	625	7	phosphopeptide	phosphopeptide	NOUN
fnp-8974	625	8	enrichment	enrichment	NOUN
fnp-8974	625	9	methods	method	NOUN
fnp-8974	625	10	and	and	CCONJ
fnp-8974	625	11	highest	high	ADJ
fnp-8974	625	12	sensitivity	sensitivity	NOUN
fnp-8974	625	13	mass	mass	NOUN
fnp-8974	625	14	spectrometers	spectrometer	NOUN
fnp-8974	625	15	coupled	couple	VERB
fnp-8974	625	16	with	with	ADP
fnp-8974	625	17	in	in	ADP
fnp-8974	625	18	-	-	PUNCT
fnp-8974	625	19	depth	depth	NOUN
fnp-8974	625	20	computational	computational	ADJ
fnp-8974	625	21	data	datum	NOUN
fnp-8974	625	22	analysis	analysis	NOUN
fnp-8974	625	23	pipelines	pipeline	NOUN
fnp-8974	625	24	.	.	PUNCT
fnp-8974	626	1	in	in	ADP
fnp-8974	626	2	this	this	DET
fnp-8974	626	3	context	context	NOUN
fnp-8974	626	4	,	,	PUNCT
fnp-8974	626	5	our	our	PRON
fnp-8974	626	6	team	team	NOUN
fnp-8974	626	7	at	at	ADP
fnp-8974	626	8	the	the	DET
fnp-8974	626	9	division	division	NOUN
fnp-8974	626	10	of	of	ADP
fnp-8974	626	11	neuropathology	neuropathology	NOUN
fnp-8974	626	12	in	in	ADP
fnp-8974	626	13	heidelberg	heidelberg	PROPN
fnp-8974	626	14	has	have	AUX
fnp-8974	626	15	implemented	implement	VERB
fnp-8974	626	16	a	a	DET
fnp-8974	626	17	low	low	ADJ
fnp-8974	626	18	-	-	PUNCT
fnp-8974	626	19	input	input	NOUN
fnp-8974	626	20	phosphoproteomic	phosphoproteomic	ADJ
fnp-8974	626	21	workflow	workflow	NOUN
fnp-8974	626	22	optimized	optimize	VERB
fnp-8974	626	23	for	for	ADP
fnp-8974	626	24	single	single	ADJ
fnp-8974	626	25	punches	punch	NOUN
fnp-8974	626	26	of	of	ADP
fnp-8974	626	27	ffpe	ffpe	NOUN
fnp-8974	626	28	material	material	NOUN
fnp-8974	626	29	.	.	PUNCT
fnp-8974	627	1	the	the	DET
fnp-8974	627	2	robust	robust	ADJ
fnp-8974	627	3	and	and	CCONJ
fnp-8974	627	4	automatized	automatize	VERB
fnp-8974	627	5	phosphopeptide	phosphopeptide	NOUN
fnp-8974	627	6	enrichment	enrichment	NOUN
fnp-8974	627	7	strategy	strategy	NOUN
fnp-8974	627	8	highly	highly	ADV
fnp-8974	627	9	improves	improve	VERB
fnp-8974	627	10	the	the	DET
fnp-8974	627	11	quantification	quantification	NOUN
fnp-8974	627	12	of	of	ADP
fnp-8974	627	13	phosphorylated	phosphorylate	VERB
fnp-8974	627	14	peptides	peptide	NOUN
fnp-8974	627	15	in	in	ADP
fnp-8974	627	16	clinical	clinical	ADJ
fnp-8974	627	17	samples	sample	NOUN
fnp-8974	627	18	,	,	PUNCT
fnp-8974	627	19	while	while	SCONJ
fnp-8974	627	20	the	the	DET
fnp-8974	627	21	downstream	downstream	ADJ
fnp-8974	627	22	bioinformatic	bioinformatic	ADJ
fnp-8974	627	23	analysis	analysis	NOUN
fnp-8974	627	24	enables	enable	VERB
fnp-8974	627	25	the	the	DET
fnp-8974	627	26	systematic	systematic	ADJ
fnp-8974	627	27	mapping	mapping	NOUN
fnp-8974	627	28	of	of	ADP
fnp-8974	627	29	kinase	kinase	NOUN
fnp-8974	627	30	-	-	PUNCT
fnp-8974	627	31	substrate	substrate	NOUN
fnp-8974	627	32	relationships	relationship	NOUN
fnp-8974	627	33	and	and	CCONJ
fnp-8974	627	34	elucidates	elucidate	VERB
fnp-8974	627	35	on	on	ADP
fnp-8974	627	36	signaling	signal	VERB
fnp-8974	627	37	networks	network	NOUN
fnp-8974	627	38	deregulated	deregulate	VERB
fnp-8974	627	39	in	in	ADP
fnp-8974	627	40	glioblastoma	glioblastoma	NOUN
fnp-8974	627	41	.	.	PUNCT
fnp-8974	628	1	our	our	PRON
fnp-8974	628	2	optimized	optimize	VERB
fnp-8974	628	3	phosphoproteomic	phosphoproteomic	ADJ
fnp-8974	628	4	pipeline	pipeline	NOUN
fnp-8974	628	5	dramatically	dramatically	ADV
fnp-8974	628	6	increases	increase	VERB
fnp-8974	628	7	our	our	PRON
fnp-8974	628	8	understanding	understanding	NOUN
fnp-8974	628	9	of	of	ADP
fnp-8974	628	10	glioblastoma	glioblastoma	NOUN
fnp-8974	628	11	biology	biology	NOUN
fnp-8974	628	12	while	while	SCONJ
fnp-8974	628	13	identifying	identify	VERB
fnp-8974	628	14	patients	patient	NOUN
fnp-8974	628	15	with	with	ADP
fnp-8974	628	16	active	active	ADJ
fnp-8974	628	17	signaling	signaling	NOUN
fnp-8974	628	18	in	in	ADP
fnp-8974	628	19	the	the	DET
fnp-8974	628	20	absence	absence	NOUN
fnp-8974	628	21	of	of	ADP
fnp-8974	628	22	target	target	NOUN
fnp-8974	628	23	amplification	amplification	NOUN
fnp-8974	628	24	,	,	PUNCT
fnp-8974	628	25	and	and	CCONJ
fnp-8974	628	26	holds	hold	VERB
fnp-8974	628	27	promise	promise	NOUN
fnp-8974	628	28	for	for	ADP
fnp-8974	628	29	a	a	DET
fnp-8974	628	30	more	more	ADV
fnp-8974	628	31	personalized	personalized	ADJ
fnp-8974	628	32	and	and	CCONJ
fnp-8974	628	33	effective	effective	ADJ
fnp-8974	628	34	intervention	intervention	NOUN
fnp-8974	628	35	for	for	ADP
fnp-8974	628	36	glioblastoma	glioblastoma	NOUN
fnp-8974	628	37	patients	patient	NOUN
fnp-8974	628	38	.	.	PUNCT
fnp-8974	629	1	p50	p50	NOUN
fnp-8974	629	2	free	free	ADJ
fnp-8974	629	3	neuropathol	neuropathol	NOUN
fnp-8974	629	4	6:17:73	6:17:73	NUM
fnp-8974	629	5	meningioma	meningioma	NOUN
fnp-8974	629	6	sanity	sanity	NOUN
fnp-8974	629	7	check	check	NOUN
fnp-8974	629	8	:	:	PUNCT
fnp-8974	629	9	increasing	increase	VERB
fnp-8974	629	10	classifier	classifier	NOUN
fnp-8974	629	11	credibility	credibility	NOUN
fnp-8974	629	12	through	through	ADP
fnp-8974	629	13	prototypical	prototypical	ADJ
fnp-8974	629	14	feature	feature	NOUN
fnp-8974	629	15	statistics	statistic	NOUN
fnp-8974	629	16	kai	kai	PROPN
fnp-8974	630	1	schmid1	schmid1	ADV
fnp-8974	630	2	,	,	PUNCT
fnp-8974	630	3	hildegard	hildegard	PROPN
fnp-8974	630	4	dohmen1	dohmen1	PROPN
fnp-8974	630	5	,	,	PUNCT
fnp-8974	630	6	jannik	jannik	PROPN
fnp-8974	630	7	sehring1	sehring1	PROPN
fnp-8974	630	8	,	,	PUNCT
fnp-8974	630	9	carmen	carman	NOUN
fnp-8974	630	10	selignow1	selignow1	NOUN
fnp-8974	630	11	,	,	PUNCT
fnp-8974	630	12	marco	marco	PROPN
fnp-8974	630	13	stein2	stein2	PROPN
fnp-8974	630	14	,	,	PUNCT
fnp-8974	630	15	eberhard	eberhard	NOUN
fnp-8974	630	16	uhl2	uhl2	NOUN
fnp-8974	630	17	,	,	PUNCT
fnp-8974	630	18	felix	felix	PROPN
fnp-8974	630	19	sahm3	sahm3	NOUN
fnp-8974	630	20	,	,	PUNCT
fnp-8974	630	21	till	till	SCONJ
fnp-8974	630	22	acker1	acker1	PROPN
fnp-8974	630	23	,	,	PUNCT
fnp-8974	630	24	daniel	daniel	PROPN
fnp-8974	630	25	amsel1	amsel1	PROPN
fnp-8974	630	26	1	1	NUM
fnp-8974	630	27	justus	justus	PROPN
fnp-8974	630	28	-	-	PUNCT
fnp-8974	630	29	liebig	liebig	PROPN
fnp-8974	630	30	university	university	NOUN
fnp-8974	630	31	giessen	giessen	VERB
fnp-8974	630	32	,	,	PUNCT
fnp-8974	630	33	institute	institute	NOUN
fnp-8974	630	34	of	of	ADP
fnp-8974	630	35	neuropathology	neuropathology	NOUN
fnp-8974	630	36	,	,	PUNCT
fnp-8974	630	37	giessen	giessen	VERB
fnp-8974	630	38	,	,	PUNCT
fnp-8974	630	39	germany	germany	PROPN
fnp-8974	630	40	2	2	NUM
fnp-8974	630	41	university	university	NOUN
fnp-8974	630	42	hospital	hospital	NOUN
fnp-8974	630	43	giessen	giessen	VERB
fnp-8974	630	44	und	und	PROPN
fnp-8974	630	45	marburg	marburg	PROPN
fnp-8974	630	46	location	location	NOUN
fnp-8974	630	47	giessen	giessen	PROPN
fnp-8974	630	48	,	,	PUNCT
fnp-8974	630	49	department	department	NOUN
fnp-8974	630	50	of	of	ADP
fnp-8974	630	51	neurosurgery	neurosurgery	NOUN
fnp-8974	630	52	,	,	PUNCT
fnp-8974	630	53	giessen	giessen	VERB
fnp-8974	630	54	,	,	PUNCT
fnp-8974	630	55	germany	germany	PROPN
fnp-8974	630	56	3	3	NUM
fnp-8974	630	57	institute	institute	PROPN
fnp-8974	630	58	of	of	ADP
fnp-8974	630	59	pathology	pathology	PROPN
fnp-8974	630	60	,	,	PUNCT
fnp-8974	630	61	university	university	NOUN
fnp-8974	630	62	hospital	hospital	NOUN
fnp-8974	630	63	heidelberg	heidelberg	PROPN
fnp-8974	630	64	,	,	PUNCT
fnp-8974	630	65	department	department	NOUN
fnp-8974	630	66	of	of	ADP
fnp-8974	630	67	neuropathology	neuropathology	NOUN
fnp-8974	630	68	,	,	PUNCT
fnp-8974	630	69	heidelberg	heidelberg	PROPN
fnp-8974	630	70	,	,	PUNCT
fnp-8974	630	71	germany	germany	PROPN
fnp-8974	630	72	background	background	NOUN
fnp-8974	630	73	:	:	PUNCT
fnp-8974	630	74	meningiomas	meningioma	NOUN
fnp-8974	630	75	are	be	AUX
fnp-8974	630	76	the	the	DET
fnp-8974	630	77	most	most	ADV
fnp-8974	630	78	common	common	ADJ
fnp-8974	630	79	primary	primary	ADJ
fnp-8974	630	80	brain	brain	NOUN
fnp-8974	630	81	tumors	tumor	NOUN
fnp-8974	630	82	.	.	PUNCT
fnp-8974	631	1	dna	dna	PROPN
fnp-8974	631	2	methylation	methylation	NOUN
fnp-8974	631	3	-	-	PUNCT
fnp-8974	631	4	based	base	VERB
fnp-8974	631	5	classification	classification	NOUN
fnp-8974	631	6	has	have	AUX
fnp-8974	631	7	significantly	significantly	ADV
fnp-8974	631	8	improved	improve	VERB
fnp-8974	631	9	diagnostic	diagnostic	ADJ
fnp-8974	631	10	accuracy	accuracy	NOUN
fnp-8974	631	11	and	and	CCONJ
fnp-8974	631	12	prognostication	prognostication	NOUN
fnp-8974	631	13	.	.	PUNCT
fnp-8974	632	1	however	however	ADV
fnp-8974	632	2	,	,	PUNCT
fnp-8974	632	3	current	current	ADJ
fnp-8974	632	4	classifiers	classifier	NOUN
fnp-8974	632	5	—	—	PUNCT
fnp-8974	632	6	such	such	ADJ
fnp-8974	632	7	as	as	ADP
fnp-8974	632	8	the	the	DET
fnp-8974	632	9	dkfz	dkfz	PROPN
fnp-8974	632	10	heidelberg	heidelberg	NOUN
fnp-8974	632	11	classifier	classifier	NOUN
fnp-8974	632	12	—	—	PUNCT
fnp-8974	632	13	operate	operate	VERB
fnp-8974	632	14	largely	largely	ADV
fnp-8974	632	15	as	as	ADP
fnp-8974	632	16	black	black	ADJ
fnp-8974	632	17	boxes	box	NOUN
fnp-8974	632	18	,	,	PUNCT
fnp-8974	632	19	providing	provide	VERB
fnp-8974	632	20	limited	limited	ADJ
fnp-8974	632	21	insight	insight	NOUN
fnp-8974	632	22	into	into	ADP
fnp-8974	632	23	how	how	SCONJ
fnp-8974	632	24	representative	representative	ADJ
fnp-8974	632	25	or	or	CCONJ
fnp-8974	632	26	atypical	atypical	ADJ
fnp-8974	632	27	an	an	DET
fnp-8974	632	28	individual	individual	ADJ
fnp-8974	632	29	case	case	NOUN
fnp-8974	632	30	is	be	AUX
fnp-8974	632	31	within	within	ADP
fnp-8974	632	32	its	its	PRON
fnp-8974	632	33	predicted	predict	VERB
fnp-8974	632	34	class	class	NOUN
fnp-8974	632	35	.	.	PUNCT
fnp-8974	633	1	enhancing	enhance	VERB
fnp-8974	633	2	classifier	classifier	NOUN
fnp-8974	633	3	transparency	transparency	NOUN
fnp-8974	633	4	is	be	AUX
fnp-8974	633	5	essential	essential	ADJ
fnp-8974	633	6	for	for	ADP
fnp-8974	633	7	clinical	clinical	ADJ
fnp-8974	633	8	trust	trust	NOUN
fnp-8974	633	9	and	and	CCONJ
fnp-8974	633	10	interpretability	interpretability	NOUN
fnp-8974	633	11	.	.	PUNCT
fnp-8974	634	1	methods	method	NOUN
fnp-8974	634	2	:	:	PUNCT
fnp-8974	634	3	we	we	PRON
fnp-8974	634	4	analyzed	analyze	VERB
fnp-8974	634	5	2,300	2,300	NUM
fnp-8974	634	6	meningioma	meningioma	NOUN
fnp-8974	634	7	samples	sample	NOUN
fnp-8974	634	8	profiled	profile	VERB
fnp-8974	634	9	with	with	ADP
fnp-8974	634	10	the	the	DET
fnp-8974	634	11	illumina	illumina	PROPN
fnp-8974	634	12	epic	epic	PROPN
fnp-8974	634	13	array	array	PROPN
fnp-8974	634	14	platform	platform	NOUN
fnp-8974	634	15	,	,	PUNCT
fnp-8974	634	16	including	include	VERB
fnp-8974	634	17	all	all	DET
fnp-8974	634	18	cases	case	NOUN
fnp-8974	634	19	classified	classify	VERB
fnp-8974	634	20	into	into	ADP
fnp-8974	634	21	a	a	DET
fnp-8974	634	22	meningioma	meningioma	NOUN
fnp-8974	634	23	subtype	subtype	NOUN
fnp-8974	634	24	,	,	PUNCT
fnp-8974	634	25	regardless	regardless	ADV
fnp-8974	634	26	of	of	ADP
fnp-8974	634	27	confidence	confidence	NOUN
fnp-8974	634	28	score	score	NOUN
fnp-8974	634	29	.	.	PUNCT
fnp-8974	635	1	fingerprinting	fingerprint	VERB
fnp-8974	635	2	techniques	technique	NOUN
fnp-8974	635	3	were	be	AUX
fnp-8974	635	4	applied	apply	VERB
fnp-8974	635	5	to	to	PART
fnp-8974	635	6	exclude	exclude	VERB
fnp-8974	635	7	recurrent	recurrent	ADJ
fnp-8974	635	8	samples	sample	NOUN
fnp-8974	635	9	.	.	PUNCT
fnp-8974	636	1	for	for	ADP
fnp-8974	636	2	each	each	DET
fnp-8974	636	3	subtype	subtype	NOUN
fnp-8974	636	4	,	,	PUNCT
fnp-8974	636	5	we	we	PRON
fnp-8974	636	6	computed	compute	VERB
fnp-8974	636	7	features	feature	VERB
fnp-8974	636	8	statistics	statistic	NOUN
fnp-8974	636	9	across	across	ADP
fnp-8974	636	10	multiple	multiple	ADJ
fnp-8974	636	11	axes	axis	NOUN
fnp-8974	636	12	:	:	PUNCT
fnp-8974	636	13	cnv	cnv	PROPN
fnp-8974	636	14	profiling	profiling	NOUN
fnp-8974	636	15	(	(	PUNCT
fnp-8974	636	16	conumee2	conumee2	PROPN
fnp-8974	636	17	)	)	PUNCT
fnp-8974	636	18	,	,	PUNCT
fnp-8974	636	19	tumor	tumor	NOUN
fnp-8974	636	20	microenvironment	microenvironment	NOUN
fnp-8974	636	21	(	(	PUNCT
fnp-8974	636	22	methylcibersort	methylcibersort	PROPN
fnp-8974	636	23	,	,	PUNCT
fnp-8974	636	24	methyresolver	methyresolver	ADV
fnp-8974	636	25	,	,	PUNCT
fnp-8974	636	26	epidish	epidish	ADJ
fnp-8974	636	27	,	,	PUNCT
fnp-8974	636	28	mdbraint	mdbraint	NOUN
fnp-8974	636	29	)	)	PUNCT
fnp-8974	636	30	,	,	PUNCT
fnp-8974	636	31	age	age	NOUN
fnp-8974	636	32	,	,	PUNCT
fnp-8974	636	33	differential	differential	ADJ
fnp-8974	636	34	methylation	methylation	NOUN
fnp-8974	636	35	regions	region	NOUN
fnp-8974	636	36	(	(	PUNCT
fnp-8974	636	37	dmrs	dmrs	ADJ
fnp-8974	636	38	)	)	PUNCT
fnp-8974	636	39	and	and	CCONJ
fnp-8974	636	40	oncotree	oncotree	ADV
fnp-8974	636	41	-	-	PUNCT
fnp-8974	636	42	based	base	VERB
fnp-8974	636	43	cnv	cnv	PROPN
fnp-8974	636	44	mapping	mapping	NOUN
fnp-8974	636	45	.	.	PUNCT
fnp-8974	637	1	dimensionality	dimensionality	NOUN
fnp-8974	637	2	reduction	reduction	NOUN
fnp-8974	637	3	(	(	PUNCT
fnp-8974	637	4	t	t	NOUN
fnp-8974	637	5	-	-	PUNCT
fnp-8974	637	6	sne	sne	NOUN
fnp-8974	637	7	)	)	PUNCT
fnp-8974	637	8	and	and	CCONJ
fnp-8974	637	9	gradient	gradient	ADJ
fnp-8974	637	10	boosting	boost	VERB
fnp-8974	637	11	machine	machine	NOUN
fnp-8974	637	12	(	(	PUNCT
fnp-8974	637	13	gbm	gbm	NOUN
fnp-8974	637	14	)	)	PUNCT
fnp-8974	637	15	were	be	AUX
fnp-8974	637	16	used	use	VERB
fnp-8974	637	17	to	to	PART
fnp-8974	637	18	assess	assess	VERB
fnp-8974	637	19	subtype	subtype	NOUN
fnp-8974	637	20	separability	separability	NOUN
fnp-8974	637	21	.	.	PUNCT
fnp-8974	638	1	a	a	DET
fnp-8974	638	2	composite	composite	ADJ
fnp-8974	638	3	prototypicality	prototypicality	NOUN
fnp-8974	638	4	score	score	NOUN
fnp-8974	638	5	is	be	AUX
fnp-8974	638	6	being	be	AUX
fnp-8974	638	7	developed	develop	VERB
fnp-8974	638	8	to	to	PART
fnp-8974	638	9	quantify	quantify	VERB
fnp-8974	638	10	how	how	SCONJ
fnp-8974	638	11	typical	typical	ADJ
fnp-8974	638	12	a	a	DET
fnp-8974	638	13	case	case	NOUN
fnp-8974	638	14	is	be	AUX
fnp-8974	638	15	within	within	ADP
fnp-8974	638	16	its	its	PRON
fnp-8974	638	17	predicted	predict	VERB
fnp-8974	638	18	class	class	NOUN
fnp-8974	638	19	.	.	PUNCT
fnp-8974	639	1	results	result	NOUN
fnp-8974	639	2	:	:	PUNCT
fnp-8974	639	3	subtype	subtype	NOUN
fnp-8974	639	4	assignments	assignment	NOUN
fnp-8974	639	5	were	be	AUX
fnp-8974	639	6	consistent	consistent	ADJ
fnp-8974	639	7	across	across	ADP
fnp-8974	639	8	methods	method	NOUN
fnp-8974	639	9	and	and	CCONJ
fnp-8974	639	10	reflected	reflect	VERB
fnp-8974	639	11	distinct	distinct	ADJ
fnp-8974	639	12	biological	biological	ADJ
fnp-8974	639	13	profiles	profile	NOUN
fnp-8974	639	14	.	.	PUNCT
fnp-8974	640	1	cnv	cnv	NOUN
fnp-8974	640	2	analyses	analysis	NOUN
fnp-8974	640	3	uncovered	uncover	VERB
fnp-8974	640	4	subtype	subtype	NOUN
fnp-8974	640	5	-	-	PUNCT
fnp-8974	640	6	specific	specific	ADJ
fnp-8974	640	7	alterations	alteration	NOUN
fnp-8974	640	8	correlating	correlate	VERB
fnp-8974	640	9	with	with	ADP
fnp-8974	640	10	clinical	clinical	ADJ
fnp-8974	640	11	features	feature	NOUN
fnp-8974	640	12	.	.	PUNCT
fnp-8974	641	1	deconvolution	deconvolution	NOUN
fnp-8974	641	2	identified	identify	VERB
fnp-8974	641	3	heterogeneous	heterogeneous	ADJ
fnp-8974	641	4	immune	immune	ADJ
fnp-8974	641	5	and	and	CCONJ
fnp-8974	641	6	stromal	stromal	ADJ
fnp-8974	641	7	cell	cell	NOUN
fnp-8974	641	8	populations	population	NOUN
fnp-8974	641	9	.	.	PUNCT
fnp-8974	642	1	preliminary	preliminary	ADJ
fnp-8974	642	2	gbm	gbm	PROPN
fnp-8974	642	3	models	model	NOUN
fnp-8974	642	4	demonstrated	demonstrate	VERB
fnp-8974	642	5	predictive	predictive	ADJ
fnp-8974	642	6	performance	performance	NOUN
fnp-8974	642	7	for	for	ADP
fnp-8974	642	8	subtype	subtype	NOUN
fnp-8974	642	9	assignment	assignment	NOUN
fnp-8974	642	10	.	.	PUNCT
fnp-8974	643	1	conclusion	conclusion	NOUN
fnp-8974	643	2	:	:	PUNCT
fnp-8974	643	3	this	this	DET
fnp-8974	643	4	large	large	ADJ
fnp-8974	643	5	-	-	PUNCT
fnp-8974	643	6	scale	scale	NOUN
fnp-8974	643	7	methylation	methylation	NOUN
fnp-8974	643	8	study	study	NOUN
fnp-8974	643	9	enhances	enhance	VERB
fnp-8974	643	10	understanding	understanding	NOUN
fnp-8974	643	11	of	of	ADP
fnp-8974	643	12	methylation	methylation	NOUN
fnp-8974	643	13	-	-	PUNCT
fnp-8974	643	14	based	base	VERB
fnp-8974	643	15	meningioma	meningioma	NOUN
fnp-8974	643	16	classification	classification	NOUN
fnp-8974	643	17	and	and	CCONJ
fnp-8974	643	18	supports	support	VERB
fnp-8974	643	19	the	the	DET
fnp-8974	643	20	development	development	NOUN
fnp-8974	643	21	of	of	ADP
fnp-8974	643	22	trust	trust	NOUN
fnp-8974	643	23	-	-	PUNCT
fnp-8974	643	24	enhancing	enhance	VERB
fnp-8974	643	25	tools	tool	NOUN
fnp-8974	643	26	.	.	PUNCT
fnp-8974	644	1	ongoing	ongoing	ADJ
fnp-8974	644	2	work	work	NOUN
fnp-8974	644	3	aims	aim	VERB
fnp-8974	644	4	to	to	PART
fnp-8974	644	5	implement	implement	VERB
fnp-8974	644	6	a	a	DET
fnp-8974	644	7	prototypicality	prototypicality	NOUN
fnp-8974	644	8	score	score	NOUN
fnp-8974	644	9	and	and	CCONJ
fnp-8974	644	10	provide	provide	VERB
fnp-8974	644	11	a	a	DET
fnp-8974	644	12	web	web	NOUN
fnp-8974	644	13	interface	interface	NOUN
fnp-8974	644	14	for	for	ADP
fnp-8974	644	15	classifier	classifier	NOUN
fnp-8974	644	16	inspection	inspection	NOUN
fnp-8974	644	17	and	and	CCONJ
fnp-8974	644	18	visualization	visualization	NOUN
fnp-8974	644	19	from	from	ADP
fnp-8974	644	20	uploaded	uploaded	ADJ
fnp-8974	644	21	.idat	.idat	NOUN
fnp-8974	644	22	files	file	NOUN
fnp-8974	644	23	and	and	CCONJ
fnp-8974	644	24	clinical	clinical	ADJ
fnp-8974	644	25	metadata	metadata	NOUN
fnp-8974	644	26	.	.	PUNCT
fnp-8974	645	1	copyright	copyright	NOUN
fnp-8974	645	2	:	:	PUNCT
fnp-8974	645	3	©	©	PROPN
fnp-8974	645	4	2025	2025	NUM
fnp-8974	645	5	the	the	DET
fnp-8974	645	6	author(s	author(s	NOUN
fnp-8974	645	7	)	)	PUNCT
fnp-8974	645	8	.	.	PUNCT
fnp-8974	646	1	this	this	PRON
fnp-8974	646	2	is	be	AUX
fnp-8974	646	3	an	an	DET
fnp-8974	646	4	open	open	ADJ
fnp-8974	646	5	access	access	NOUN
fnp-8974	646	6	article	article	NOUN
fnp-8974	646	7	distributed	distribute	VERB
fnp-8974	646	8	under	under	ADP
fnp-8974	646	9	the	the	DET
fnp-8974	646	10	terms	term	NOUN
fnp-8974	646	11	of	of	ADP
fnp-8974	646	12	the	the	DET
fnp-8974	646	13	creative	creative	ADJ
fnp-8974	646	14	commons	common	NOUN
fnp-8974	646	15	attribution	attribution	NOUN
fnp-8974	646	16	4.0	4.0	NUM
fnp-8974	646	17	international	international	ADJ
fnp-8974	646	18	license	license	NOUN
fnp-8974	646	19	(	(	PUNCT
fnp-8974	646	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-8974	646	21	)	)	PUNCT
fnp-8974	646	22	,	,	PUNCT
fnp-8974	646	23	which	which	PRON
fnp-8974	646	24	permits	permit	VERB
fnp-8974	646	25	unrestricted	unrestricted	ADJ
fnp-8974	646	26	use	use	NOUN
fnp-8974	646	27	,	,	PUNCT
fnp-8974	646	28	distribution	distribution	NOUN
fnp-8974	646	29	,	,	PUNCT
fnp-8974	646	30	and	and	CCONJ
fnp-8974	646	31	reproduction	reproduction	NOUN
fnp-8974	646	32	in	in	ADP
fnp-8974	646	33	any	any	DET
fnp-8974	646	34	medium	medium	NOUN
fnp-8974	646	35	,	,	PUNCT
fnp-8974	646	36	provided	provide	VERB
fnp-8974	646	37	the	the	DET
fnp-8974	646	38	original	original	ADJ
fnp-8974	646	39	author	author	NOUN
fnp-8974	646	40	and	and	CCONJ
fnp-8974	646	41	source	source	NOUN
fnp-8974	646	42	are	be	AUX
fnp-8974	646	43	credited	credit	VERB
fnp-8974	646	44	,	,	PUNCT
fnp-8974	646	45	a	a	DET
fnp-8974	646	46	link	link	NOUN
fnp-8974	646	47	to	to	ADP
fnp-8974	646	48	the	the	DET
fnp-8974	646	49	creative	creative	ADJ
fnp-8974	646	50	commons	common	NOUN
fnp-8974	646	51	license	license	NOUN
fnp-8974	646	52	is	be	AUX
fnp-8974	646	53	provided	provide	VERB
fnp-8974	646	54	,	,	PUNCT
fnp-8974	646	55	and	and	CCONJ
fnp-8974	646	56	any	any	DET
fnp-8974	646	57	changes	change	NOUN
fnp-8974	646	58	are	be	AUX
fnp-8974	646	59	indicated	indicate	VERB
fnp-8974	646	60	.	.	PUNCT
fnp-8974	647	1	the	the	DET
fnp-8974	647	2	creative	creative	ADJ
fnp-8974	647	3	commons	common	NOUN
fnp-8974	647	4	public	public	ADJ
fnp-8974	647	5	domain	domain	NOUN
fnp-8974	647	6	dedication	dedication	NOUN
fnp-8974	647	7	waiver	waiver	NOUN
fnp-8974	647	8	(	(	PUNCT
fnp-8974	647	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-8974	647	10	)	)	PUNCT
fnp-8974	647	11	applies	apply	VERB
fnp-8974	647	12	to	to	ADP
fnp-8974	647	13	the	the	DET
fnp-8974	647	14	data	datum	NOUN
fnp-8974	647	15	made	make	VERB
fnp-8974	647	16	available	available	ADJ
fnp-8974	647	17	in	in	ADP
fnp-8974	647	18	this	this	DET
fnp-8974	647	19	article	article	NOUN
fnp-8974	647	20	,	,	PUNCT
fnp-8974	647	21	unless	unless	SCONJ
fnp-8974	647	22	otherwise	otherwise	ADV
fnp-8974	647	23	stated	state	VERB
fnp-8974	647	24	.	.	PUNCT