id sid tid token lemma pos fnp-9165 1 1 65th 65th ADJ fnp-9165 1 2 annual annual ADJ fnp-9165 1 3 meeting meeting NOUN fnp-9165 1 4 of of ADP fnp-9165 1 5 the the DET fnp-9165 1 6 canadian canadian PROPN fnp-9165 1 7 association association PROPN fnp-9165 1 8 of of ADP fnp-9165 1 9 neuropathologists neuropathologists PROPN fnp-9165 1 10 association association PROPN fnp-9165 1 11 canadienne canadienne PROPN fnp-9165 1 12 des des PROPN fnp-9165 1 13 neuropathologistes neuropathologistes PROPN fnp-9165 1 14 ( ( PUNCT fnp-9165 1 15 canp canp NOUN fnp-9165 1 16 - - PUNCT fnp-9165 1 17 acnp acnp NOUN fnp-9165 1 18 ) ) PUNCT fnp-9165 1 19 feel feel VERB fnp-9165 1 20 free free ADJ fnp-9165 1 21 to to PART fnp-9165 1 22 add add VERB fnp-9165 1 23 comments comment NOUN fnp-9165 1 24 by by ADP fnp-9165 1 25 clicking click VERB fnp-9165 1 26 these these DET fnp-9165 1 27 icons icon NOUN fnp-9165 1 28 on on ADP fnp-9165 1 29 the the DET fnp-9165 1 30 sidebar sidebar NOUN fnp-9165 1 31 free free ADJ fnp-9165 1 32 neuropathology neuropathology NOUN fnp-9165 1 33 6:23(2025 6:23(2025 NUM fnp-9165 1 34 ) ) PUNCT fnp-9165 2 1 meeting meeting NOUN fnp-9165 2 2 abstracts abstract VERB fnp-9165 2 3 65th 65th ADJ fnp-9165 2 4 annual annual ADJ fnp-9165 2 5 meeting meeting NOUN fnp-9165 2 6 of of ADP fnp-9165 2 7 the the DET fnp-9165 2 8 canadian canadian PROPN fnp-9165 2 9 association association PROPN fnp-9165 2 10 of of ADP fnp-9165 2 11 neuropathologists neuropathologists PROPN fnp-9165 2 12 association association PROPN fnp-9165 2 13 canadienne canadienne PROPN fnp-9165 2 14 des des PROPN fnp-9165 2 15 neuropathologistes neuropathologistes PROPN fnp-9165 2 16 ( ( PUNCT fnp-9165 2 17 canp canp NOUN fnp-9165 2 18 - - PUNCT fnp-9165 2 19 acnp acnp NOUN fnp-9165 2 20 ) ) PUNCT fnp-9165 2 21 meeting meeting NOUN fnp-9165 2 22 abstracts abstract VERB fnp-9165 2 23 october october PROPN fnp-9165 2 24 23rd–25th 23rd–25th NUM fnp-9165 2 25 , , PUNCT fnp-9165 2 26 2025 2025 NUM fnp-9165 2 27 banff banff PROPN fnp-9165 2 28 , , PUNCT fnp-9165 2 29 alberta alberta PROPN fnp-9165 2 30 submitted submit VERB fnp-9165 2 31 : : PUNCT fnp-9165 2 32 28 28 NUM fnp-9165 2 33 november november PROPN fnp-9165 2 34 2025 2025 NUM fnp-9165 2 35 accepted accept VERB fnp-9165 2 36 : : PUNCT fnp-9165 2 37 29 29 NUM fnp-9165 2 38 november november NOUN fnp-9165 2 39 2025 2025 NUM fnp-9165 2 40 published publish VERB fnp-9165 2 41 : : PUNCT fnp-9165 2 42 04 04 NUM fnp-9165 2 43 december december PROPN fnp-9165 2 44 2025 2025 NUM fnp-9165 2 45     SPACE fnp-9165 2 46 the the DET fnp-9165 2 47 canadian canadian PROPN fnp-9165 2 48 association association NOUN fnp-9165 2 49 of of ADP fnp-9165 2 50 neuropathologists neuropathologist NOUN fnp-9165 2 51 – – PUNCT fnp-9165 2 52 association association PROPN fnp-9165 2 53 canadienne canadienne PROPN fnp-9165 2 54 des des X fnp-9165 2 55 neuropathologistes neuropathologistes PROPN fnp-9165 2 56 ( ( PUNCT fnp-9165 2 57 canp canp NOUN fnp-9165 2 58 - - PUNCT fnp-9165 2 59 acnp acnp NOUN fnp-9165 2 60 ) ) PUNCT fnp-9165 2 61 held hold VERB fnp-9165 2 62 their their PRON fnp-9165 2 63 65th 65th ADJ fnp-9165 2 64 annual annual ADJ fnp-9165 2 65 meeting meeting NOUN fnp-9165 2 66 at at ADP fnp-9165 2 67 the the DET fnp-9165 2 68 banff banff PROPN fnp-9165 2 69 centre centre PROPN fnp-9165 2 70 for for ADP fnp-9165 2 71 arts art NOUN fnp-9165 2 72 & & CCONJ fnp-9165 2 73 creativity creativity NOUN fnp-9165 2 74 – – PUNCT fnp-9165 2 75 banff banff PROPN fnp-9165 2 76 , , PUNCT fnp-9165 2 77 alberta alberta PROPN fnp-9165 2 78 , , PUNCT fnp-9165 2 79 from from ADP fnp-9165 2 80 october october PROPN fnp-9165 2 81 23rd–25th 23rd–25th NUM fnp-9165 2 82 , , PUNCT fnp-9165 2 83 2025 2025 NUM fnp-9165 2 84 , , PUNCT fnp-9165 2 85 under under ADP fnp-9165 2 86 the the DET fnp-9165 2 87 leadership leadership NOUN fnp-9165 2 88 of of ADP fnp-9165 2 89 dr dr PROPN fnp-9165 2 90 . . PROPN fnp-9165 2 91 cynthia cynthia PROPN fnp-9165 2 92 hawkins hawkins PROPN fnp-9165 2 93 , , PUNCT fnp-9165 2 94 president president NOUN fnp-9165 2 95 of of ADP fnp-9165 2 96 the the DET fnp-9165 2 97 canp canp NOUN fnp-9165 2 98 - - PUNCT fnp-9165 2 99 acnp acnp ADJ fnp-9165 2 100 , , PUNCT fnp-9165 2 101 dr dr PROPN fnp-9165 2 102 . . PROPN fnp-9165 2 103 veronica veronica PROPN fnp-9165 2 104 hirsch hirsch PROPN fnp-9165 2 105 - - PUNCT fnp-9165 2 106 reinshagen reinshagen PROPN fnp-9165 2 107 , , PUNCT fnp-9165 2 108 secretary secretary NOUN fnp-9165 2 109 treasurer treasurer NOUN fnp-9165 2 110 of of ADP fnp-9165 2 111 the the DET fnp-9165 2 112 canp canp NOUN fnp-9165 2 113 - - PUNCT fnp-9165 2 114 acnp acnp NOUN fnp-9165 2 115 , , PUNCT fnp-9165 2 116 and and CCONJ fnp-9165 2 117 with with ADP fnp-9165 2 118 technical technical ADJ fnp-9165 2 119 support support NOUN fnp-9165 2 120 from from ADP fnp-9165 2 121 canp canp ADJ fnp-9165 2 122 administrator administrator NOUN fnp-9165 2 123 colleen colleen PROPN fnp-9165 2 124 fifield fifield PROPN fnp-9165 2 125 . . PUNCT fnp-9165 3 1 the the DET fnp-9165 3 2 academic academic ADJ fnp-9165 3 3 program program NOUN fnp-9165 3 4 comprised comprise VERB fnp-9165 3 5 23 23 NUM fnp-9165 3 6 scientific scientific ADJ fnp-9165 3 7 abstracts abstract NOUN fnp-9165 3 8 , , PUNCT fnp-9165 3 9 13 13 NUM fnp-9165 3 10 unknown unknown ADJ fnp-9165 3 11 cases case NOUN fnp-9165 3 12 , , PUNCT fnp-9165 3 13 the the DET fnp-9165 3 14 neuropathology neuropathology NOUN fnp-9165 3 15 in in ADP fnp-9165 3 16 practice practice NOUN fnp-9165 3 17 forum forum NOUN fnp-9165 3 18 on on ADP fnp-9165 3 19 immunohistochemical immunohistochemical ADJ fnp-9165 3 20 markers marker NOUN fnp-9165 3 21 for for ADP fnp-9165 3 22 inflammatory inflammatory ADJ fnp-9165 3 23 myopathies myopathy NOUN fnp-9165 3 24 , , PUNCT fnp-9165 3 25 and and CCONJ fnp-9165 3 26 the the DET fnp-9165 3 27 presidential presidential ADJ fnp-9165 3 28 symposium symposium NOUN fnp-9165 3 29 . . PUNCT fnp-9165 4 1 digital digital ADJ fnp-9165 4 2 pathology pathology NOUN fnp-9165 4 3 images image NOUN fnp-9165 4 4 from from ADP fnp-9165 4 5 the the DET fnp-9165 4 6 13 13 NUM fnp-9165 4 7 unknown unknown ADJ fnp-9165 4 8 cases case NOUN fnp-9165 4 9 were be AUX fnp-9165 4 10 available available ADJ fnp-9165 4 11 for for ADP fnp-9165 4 12 online online ADJ fnp-9165 4 13 viewing viewing NOUN fnp-9165 4 14 prior prior ADV fnp-9165 4 15 to to ADP fnp-9165 4 16 the the DET fnp-9165 4 17 conference conference NOUN fnp-9165 4 18 ( ( PUNCT fnp-9165 4 19 www.canp.ca www.canp.ca PROPN fnp-9165 4 20 ) ) PUNCT fnp-9165 4 21 . . PUNCT fnp-9165 5 1 the the DET fnp-9165 5 2 david david PROPN fnp-9165 5 3 robertson robertson PROPN fnp-9165 5 4 lecture lecture PROPN fnp-9165 5 5 , , PUNCT fnp-9165 5 6 pathomechanisms pathomechanism NOUN fnp-9165 5 7 at at ADP fnp-9165 5 8 the the DET fnp-9165 5 9 interface interface NOUN fnp-9165 5 10 of of ADP fnp-9165 5 11 neurological neurological ADJ fnp-9165 5 12 infectious infectious ADJ fnp-9165 5 13 and and CCONJ fnp-9165 5 14 immune immune ADJ fnp-9165 5 15 disorders disorder NOUN fnp-9165 5 16 , , PUNCT fnp-9165 5 17 was be AUX fnp-9165 5 18 delivered deliver VERB fnp-9165 5 19 by by ADP fnp-9165 5 20 dr dr PROPN fnp-9165 5 21 . . PROPN fnp-9165 5 22 christopher christopher PROPN fnp-9165 5 23 power power PROPN fnp-9165 5 24 . . PUNCT fnp-9165 6 1 the the DET fnp-9165 6 2 2025 2025 NUM fnp-9165 6 3 presidential presidential ADJ fnp-9165 6 4 symposium symposium NOUN fnp-9165 6 5 , , PUNCT fnp-9165 6 6 advanced advanced ADJ fnp-9165 6 7 perspectives perspective NOUN fnp-9165 6 8 on on ADP fnp-9165 6 9 neurodegenerative neurodegenerative ADJ fnp-9165 6 10 diseases disease NOUN fnp-9165 6 11 , , PUNCT fnp-9165 6 12 featured feature VERB fnp-9165 6 13 the the DET fnp-9165 6 14 gordon gordon PROPN fnp-9165 6 15 mathieson mathieson PROPN fnp-9165 6 16 lecture lecture PROPN fnp-9165 6 17 by by ADP fnp-9165 6 18 dr dr PROPN fnp-9165 6 19 . . PROPN fnp-9165 6 20 ian ian PROPN fnp-9165 6 21 mackenzie mackenzie PROPN fnp-9165 6 22 on on ADP fnp-9165 6 23 new new ADJ fnp-9165 6 24 approaches approach NOUN fnp-9165 6 25 to to ADP fnp-9165 6 26 neurodegenerative neurodegenerative ADJ fnp-9165 6 27 disease disease NOUN fnp-9165 6 28 diagnosis diagnosis NOUN fnp-9165 6 29 and and CCONJ fnp-9165 6 30 research research NOUN fnp-9165 6 31 , , PUNCT fnp-9165 6 32 and and CCONJ fnp-9165 6 33 the the DET fnp-9165 6 34 jerzy jerzy X fnp-9165 6 35 olszewski olszewski ADJ fnp-9165 6 36 guest guest NOUN fnp-9165 6 37 lecture lecture NOUN fnp-9165 6 38 by by ADP fnp-9165 6 39 dr dr PROPN fnp-9165 6 40 . . PROPN fnp-9165 6 41 eric eric PROPN fnp-9165 6 42 smith smith PROPN fnp-9165 6 43 entitled entitle VERB fnp-9165 6 44 vascular vascular ADJ fnp-9165 6 45 dementia dementia NOUN fnp-9165 6 46 . . PUNCT fnp-9165 7 1 the the DET fnp-9165 7 2 symposium symposium NOUN fnp-9165 7 3 also also ADV fnp-9165 7 4 included include VERB fnp-9165 7 5 three three NUM fnp-9165 7 6 invited invite VERB fnp-9165 7 7 presentations presentation NOUN fnp-9165 7 8 : : PUNCT fnp-9165 7 9 dr dr PROPN fnp-9165 7 10 . . PROPN fnp-9165 7 11 rosa rosa PROPN fnp-9165 7 12 rademakers rademaker NOUN fnp-9165 7 13 discussed discuss VERB fnp-9165 7 14 the the DET fnp-9165 7 15 role role NOUN fnp-9165 7 16 of of ADP fnp-9165 7 17 genetics genetic NOUN fnp-9165 7 18 in in ADP fnp-9165 7 19 understanding understand VERB fnp-9165 7 20 the the DET fnp-9165 7 21 pathophysiology pathophysiology NOUN fnp-9165 7 22 of of ADP fnp-9165 7 23 neurodegenerative neurodegenerative ADJ fnp-9165 7 24 diseases disease NOUN fnp-9165 7 25 ; ; PUNCT fnp-9165 7 26 dr dr PROPN fnp-9165 7 27 . . PROPN fnp-9165 7 28 edward edward PROPN fnp-9165 7 29 lee lee PROPN fnp-9165 7 30 presented present VERB fnp-9165 7 31 on on ADP fnp-9165 7 32 the the DET fnp-9165 7 33 role role NOUN fnp-9165 7 34 of of ADP fnp-9165 7 35 spatially spatially ADV fnp-9165 7 36 defined define VERB fnp-9165 7 37 omics omic NOUN fnp-9165 7 38 in in ADP fnp-9165 7 39 understanding understand VERB fnp-9165 7 40 the the DET fnp-9165 7 41 pathophysiology pathophysiology NOUN fnp-9165 7 42 of of ADP fnp-9165 7 43 neurodegenerative neurodegenerative ADJ fnp-9165 7 44 diseases disease NOUN fnp-9165 7 45 ; ; PUNCT fnp-9165 7 46 and and CCONJ fnp-9165 7 47 dr dr PROPN fnp-9165 7 48 . . PROPN fnp-9165 7 49 julie julie PROPN fnp-9165 7 50 schneider schneider PROPN fnp-9165 7 51 spoke speak VERB fnp-9165 7 52 on on ADP fnp-9165 7 53 insights insight NOUN fnp-9165 7 54 from from ADP fnp-9165 7 55 population population NOUN fnp-9165 7 56 - - PUNCT fnp-9165 7 57 based base VERB fnp-9165 7 58 studies study NOUN fnp-9165 7 59 into into ADP fnp-9165 7 60 the the DET fnp-9165 7 61 pathological pathological ADJ fnp-9165 7 62 determinants determinant NOUN fnp-9165 7 63 of of ADP fnp-9165 7 64 dementia dementia NOUN fnp-9165 7 65 . . PUNCT fnp-9165 8 1 the the DET fnp-9165 8 2 mary mary PROPN fnp-9165 8 3 tom tom PROPN fnp-9165 8 4 award award PROPN fnp-9165 8 5 for for ADP fnp-9165 8 6 best good ADJ fnp-9165 8 7 clinical clinical ADJ fnp-9165 8 8 science science NOUN fnp-9165 8 9 presentation presentation NOUN fnp-9165 8 10 by by ADP fnp-9165 8 11 a a DET fnp-9165 8 12 trainee trainee NOUN fnp-9165 8 13 went go VERB fnp-9165 8 14 to to ADP fnp-9165 8 15 dr dr PROPN fnp-9165 8 16 . . PROPN fnp-9165 8 17 erin erin PROPN fnp-9165 8 18 stephenson stephenson PROPN fnp-9165 8 19 ( ( PUNCT fnp-9165 8 20 supervisor supervisor NOUN fnp-9165 8 21 dr dr PROPN fnp-9165 8 22 . . PROPN fnp-9165 8 23 kristopher kristopher PROPN fnp-9165 8 24 d. d. PROPN fnp-9165 8 25 langdon langdon PROPN fnp-9165 8 26 ) ) PUNCT fnp-9165 8 27 , , PUNCT fnp-9165 8 28 and and CCONJ fnp-9165 8 29 the the DET fnp-9165 8 30 morrison morrison PROPN fnp-9165 8 31 h. h. PROPN fnp-9165 8 32 finlayson finlayson PROPN fnp-9165 8 33 award award PROPN fnp-9165 8 34 for for ADP fnp-9165 8 35 best good ADJ fnp-9165 8 36 basic basic ADJ fnp-9165 8 37 science science NOUN fnp-9165 8 38 presentation presentation NOUN fnp-9165 8 39 by by ADP fnp-9165 8 40 a a DET fnp-9165 8 41 trainee trainee NOUN fnp-9165 8 42 was be AUX fnp-9165 8 43 won win VERB fnp-9165 8 44 by by ADP fnp-9165 8 45 dr dr PROPN fnp-9165 8 46 . . PROPN fnp-9165 8 47 karina karina PROPN fnp-9165 8 48 martin martin PROPN fnp-9165 8 49 ( ( PUNCT fnp-9165 8 50 supervisor supervisor NOUN fnp-9165 8 51 harry harry PROPN fnp-9165 8 52 v. v. ADP fnp-9165 8 53 vinters vinter NOUN fnp-9165 8 54 ) ) PUNCT fnp-9165 8 55 . . PUNCT fnp-9165 9 1 the the DET fnp-9165 9 2 following follow VERB fnp-9165 9 3 abstracts abstract NOUN fnp-9165 9 4 were be AUX fnp-9165 9 5 presented present VERB fnp-9165 9 6 at at ADP fnp-9165 9 7 the the DET fnp-9165 9 8 65th 65th ADJ fnp-9165 9 9 annual annual ADJ fnp-9165 9 10 meeting meeting NOUN fnp-9165 9 11 of of ADP fnp-9165 9 12 the the DET fnp-9165 9 13 canadian canadian PROPN fnp-9165 9 14 association association NOUN fnp-9165 9 15 of of ADP fnp-9165 9 16 neuropathologists neuropathologist NOUN fnp-9165 9 17 – – PUNCT fnp-9165 9 18 association association PROPN fnp-9165 9 19 candienne candienne PROPN fnp-9165 9 20 des des PROPN fnp-9165 9 21 neuropathologistes neuropathologistes PROPN fnp-9165 9 22 ( ( PUNCT fnp-9165 9 23 canp canp NOUN fnp-9165 9 24 - - PUNCT fnp-9165 9 25 acnp acnp NOUN fnp-9165 9 26 ) ) PUNCT fnp-9165 9 27 in in ADP fnp-9165 9 28 october october PROPN fnp-9165 9 29 2025 2025 NUM fnp-9165 9 30 . . PUNCT fnp-9165 9 31     SPACE fnp-9165 10 1 https://doi.org/10.17879/freeneuropathology-2025-9165 https://doi.org/10.17879/freeneuropathology-2025-9165 NOUN fnp-9165 10 2 keywords keyword NOUN fnp-9165 10 3 : : PUNCT fnp-9165 10 4 canadian canadian ADJ fnp-9165 10 5 association association NOUN fnp-9165 10 6 of of ADP fnp-9165 10 7 neuropathologists neuropathologist NOUN fnp-9165 10 8 , , PUNCT fnp-9165 10 9 canp canp NOUN fnp-9165 10 10 , , PUNCT fnp-9165 10 11 meeting meet VERB fnp-9165 10 12 abstracts abstract NOUN fnp-9165 10 13 , , PUNCT fnp-9165 10 14 65th 65th ADJ fnp-9165 10 15 meeting meeting NOUN fnp-9165 10 16 oct oct PROPN fnp-9165 10 17 . . PROPN fnp-9165 10 18 2025 2025 NUM fnp-9165 10 19 contents content NOUN fnp-9165 10 20 abstract abstract ADJ fnp-9165 10 21     SPACE fnp-9165 10 22 1 1 NUM fnp-9165 10 23 : : PUNCT fnp-9165 10 24 decoding decode VERB fnp-9165 10 25 the the DET fnp-9165 10 26 diseased diseased ADJ fnp-9165 10 27 brain brain NOUN fnp-9165 10 28 : : PUNCT fnp-9165 10 29 using use VERB fnp-9165 10 30 machine machine NOUN fnp-9165 10 31 learning learn VERB fnp-9165 10 32 to to PART fnp-9165 10 33 gain gain VERB fnp-9165 10 34 comprehensive comprehensive ADJ fnp-9165 10 35 understanding understanding NOUN fnp-9165 10 36 of of ADP fnp-9165 10 37 neurodegenerative neurodegenerative ADJ fnp-9165 10 38 diseases disease NOUN fnp-9165 10 39 abstract abstract ADJ fnp-9165 10 40     SPACE fnp-9165 10 41 2 2 NUM fnp-9165 10 42 : : PUNCT fnp-9165 10 43 the the DET fnp-9165 10 44 relevance relevance NOUN fnp-9165 10 45 of of ADP fnp-9165 10 46 identifying identify VERB fnp-9165 10 47 limbic limbic ADJ fnp-9165 10 48 neuronal neuronal ADJ fnp-9165 10 49 synuclein synuclein NOUN fnp-9165 10 50 pathology pathology NOUN fnp-9165 10 51 in in ADP fnp-9165 10 52 multiple multiple ADJ fnp-9165 10 53 system system NOUN fnp-9165 10 54 atrophy atrophy NOUN fnp-9165 10 55 abstract abstract NOUN fnp-9165 10 56     SPACE fnp-9165 10 57 3 3 NUM fnp-9165 10 58 : : PUNCT fnp-9165 10 59 spinal spinal ADJ fnp-9165 10 60 cord cord NOUN fnp-9165 10 61 α α NOUN fnp-9165 10 62 - - PUNCT fnp-9165 10 63 synuclein synuclein NOUN fnp-9165 10 64 mapping mapping NOUN fnp-9165 10 65 in in ADP fnp-9165 10 66 parkinson parkinson NOUN fnp-9165 10 67 ’s ’s PART fnp-9165 10 68 disease disease NOUN fnp-9165 10 69 abstract abstract NOUN fnp-9165 10 70     SPACE fnp-9165 10 71 4 4 NUM fnp-9165 10 72 : : PUNCT fnp-9165 10 73 comparison comparison NOUN fnp-9165 10 74 of of ADP fnp-9165 10 75 co co NOUN fnp-9165 10 76 - - NOUN fnp-9165 10 77 pathologies pathology NOUN fnp-9165 10 78 in in ADP fnp-9165 10 79 cte cte PROPN fnp-9165 10 80 - - PUNCT fnp-9165 10 81 nc nc PROPN fnp-9165 10 82 and and CCONJ fnp-9165 10 83 ggt ggt PROPN fnp-9165 10 84 and and CCONJ fnp-9165 10 85 case case NOUN fnp-9165 10 86 report report NOUN fnp-9165 10 87 of of ADP fnp-9165 10 88 an an DET fnp-9165 10 89 ex ex NOUN fnp-9165 10 90 - - ADJ fnp-9165 10 91 football football NOUN fnp-9165 10 92 player player NOUN fnp-9165 10 93 abstract abstract NOUN fnp-9165 10 94     SPACE fnp-9165 10 95 5 5 NUM fnp-9165 10 96 : : PUNCT fnp-9165 10 97 does do AUX fnp-9165 10 98 the the DET fnp-9165 10 99 hla hla PROPN fnp-9165 10 100 locus locus NOUN fnp-9165 10 101 have have VERB fnp-9165 10 102 relevance relevance NOUN fnp-9165 10 103 in in ADP fnp-9165 10 104 progressing progress VERB fnp-9165 10 105 supranuclear supranuclear ADJ fnp-9165 10 106 palsy palsy ADJ fnp-9165 10 107 ? ? PUNCT fnp-9165 11 1 abstract abstract ADJ fnp-9165 11 2     SPACE fnp-9165 11 3 6 6 NUM fnp-9165 11 4 : : PUNCT fnp-9165 11 5 cognitive cognitive ADJ fnp-9165 11 6 subtyping subtyping NOUN fnp-9165 11 7 in in ADP fnp-9165 11 8 schizophrenia schizophrenia NOUN fnp-9165 11 9 reveals reveal VERB fnp-9165 11 10 distinct distinct ADJ fnp-9165 11 11 clinicopathologic clinicopathologic ADJ fnp-9165 11 12 signatures signature NOUN fnp-9165 11 13 and and CCONJ fnp-9165 11 14 a a DET fnp-9165 11 15 vascular vascular NOUN fnp-9165 11 16 - - PUNCT fnp-9165 11 17 linked link VERB fnp-9165 11 18 cognitive cognitive ADJ fnp-9165 11 19 phenotype phenotype NOUN fnp-9165 11 20 abstract abstract NOUN fnp-9165 11 21     SPACE fnp-9165 11 22 7 7 NUM fnp-9165 11 23 : : PUNCT fnp-9165 11 24 mapping map VERB fnp-9165 11 25 the the DET fnp-9165 11 26 digital digital ADJ fnp-9165 11 27 divide divide NOUN fnp-9165 11 28 : : PUNCT fnp-9165 11 29 underrepresentation underrepresentation NOUN fnp-9165 11 30 of of ADP fnp-9165 11 31 neuropathology neuropathology NOUN fnp-9165 11 32 in in ADP fnp-9165 11 33 large large ADJ fnp-9165 11 34 language language NOUN fnp-9165 11 35 model model NOUN fnp-9165 11 36 - - PUNCT fnp-9165 11 37 driven drive VERB fnp-9165 11 38 diagnostic diagnostic ADJ fnp-9165 11 39 literature literature NOUN fnp-9165 11 40 abstract abstract NOUN fnp-9165 11 41     SPACE fnp-9165 11 42 8 8 NUM fnp-9165 11 43 : : PUNCT fnp-9165 11 44 onsight onsight NOUN fnp-9165 11 45 : : PUNCT fnp-9165 11 46 a a DET fnp-9165 11 47 real real ADJ fnp-9165 11 48 - - PUNCT fnp-9165 11 49 time time NOUN fnp-9165 11 50 computational computational ADJ fnp-9165 11 51 pathology pathology NOUN fnp-9165 11 52 companion companion NOUN fnp-9165 11 53 for for ADP fnp-9165 11 54 histopathology histopathology NOUN fnp-9165 11 55 abstract abstract NOUN fnp-9165 11 56     SPACE fnp-9165 11 57 9 9 NUM fnp-9165 11 58 : : PUNCT fnp-9165 11 59 validation validation NOUN fnp-9165 11 60 framework framework NOUN fnp-9165 11 61 for for ADP fnp-9165 11 62 an an DET fnp-9165 11 63 ai ai ADJ fnp-9165 11 64 decision decision NOUN fnp-9165 11 65 support support NOUN fnp-9165 11 66 tool tool NOUN fnp-9165 11 67 in in ADP fnp-9165 11 68 intraoperative intraoperative ADJ fnp-9165 11 69 neuropathology neuropathology NOUN fnp-9165 11 70 : : PUNCT fnp-9165 11 71 protocol protocol NOUN fnp-9165 11 72 for for ADP fnp-9165 11 73 a a DET fnp-9165 11 74 multi multi ADJ fnp-9165 11 75 - - ADJ fnp-9165 11 76 phase phase NOUN fnp-9165 11 77 evaluation evaluation NOUN fnp-9165 11 78 abstract abstract NOUN fnp-9165 11 79     SPACE fnp-9165 11 80 10 10 NUM fnp-9165 11 81 : : PUNCT fnp-9165 11 82 an an DET fnp-9165 11 83 internal internal ADJ fnp-9165 11 84 audit audit NOUN fnp-9165 11 85 of of ADP fnp-9165 11 86 neuropathology neuropathology NOUN fnp-9165 11 87 consultation consultation NOUN fnp-9165 11 88 for for ADP fnp-9165 11 89 autopsies autopsy NOUN fnp-9165 11 90 at at ADP fnp-9165 11 91 the the DET fnp-9165 11 92 london london PROPN fnp-9165 11 93 health health PROPN fnp-9165 11 94 sciences sciences PROPN fnp-9165 11 95 centre centre PROPN fnp-9165 11 96 – – PUNCT fnp-9165 11 97 a a DET fnp-9165 11 98 quality quality NOUN fnp-9165 11 99 improvement improvement NOUN fnp-9165 11 100 project project NOUN fnp-9165 11 101 abstract abstract NOUN fnp-9165 11 102     SPACE fnp-9165 11 103 11 11 NUM fnp-9165 11 104 : : PUNCT fnp-9165 11 105 ischemic ischemic ADJ fnp-9165 11 106 stroke stroke NOUN fnp-9165 11 107 in in ADP fnp-9165 11 108 hypereosinophilic hypereosinophilic ADJ fnp-9165 11 109 syndrome syndrome NOUN fnp-9165 11 110 : : PUNCT fnp-9165 11 111 a a DET fnp-9165 11 112 clinicopathologic clinicopathologic ADJ fnp-9165 11 113 study study NOUN fnp-9165 11 114 of of ADP fnp-9165 11 115 two two NUM fnp-9165 11 116 cases case NOUN fnp-9165 11 117 abstract abstract ADJ fnp-9165 11 118     SPACE fnp-9165 11 119 12 12 NUM fnp-9165 11 120 : : PUNCT fnp-9165 11 121 neuropathological neuropathological ADJ fnp-9165 11 122 correlates correlate VERB fnp-9165 11 123 of of ADP fnp-9165 11 124 serum serum NOUN fnp-9165 11 125 biomarkers biomarker NOUN fnp-9165 11 126 during during ADP fnp-9165 11 127 the the DET fnp-9165 11 128 dying die VERB fnp-9165 11 129 process process NOUN fnp-9165 11 130 in in ADP fnp-9165 11 131 humans human NOUN fnp-9165 11 132 abstract abstract ADJ fnp-9165 11 133     SPACE fnp-9165 11 134 13 13 NUM fnp-9165 11 135 : : PUNCT fnp-9165 11 136 brainstem brainstem NOUN fnp-9165 11 137 cap cap NOUN fnp-9165 11 138 dysplasias dysplasias PROPN fnp-9165 11 139 : : PUNCT fnp-9165 11 140 pathology pathology NOUN fnp-9165 11 141 and and CCONJ fnp-9165 11 142 novel novel ADJ fnp-9165 11 143 descriptions description NOUN fnp-9165 11 144 abstract abstract ADJ fnp-9165 11 145     SPACE fnp-9165 11 146 14 14 NUM fnp-9165 11 147 : : PUNCT fnp-9165 11 148 keratan keratan PROPN fnp-9165 11 149 sulfate sulfate NOUN fnp-9165 11 150 proteoglycan proteoglycan NOUN fnp-9165 11 151 is be AUX fnp-9165 11 152 not not PART fnp-9165 11 153 expressed express VERB fnp-9165 11 154 in in ADP fnp-9165 11 155 the the DET fnp-9165 11 156 human human ADJ fnp-9165 11 157 fetal fetal ADJ fnp-9165 11 158 cerebellar cerebellar ADJ fnp-9165 11 159 system system NOUN fnp-9165 11 160 except except SCONJ fnp-9165 11 161 in in ADP fnp-9165 11 162 pontine pontine ADJ fnp-9165 11 163 nuclei nucleus NOUN fnp-9165 11 164 and and CCONJ fnp-9165 11 165 transitory transitory ADJ fnp-9165 11 166 vermal vermal ADJ fnp-9165 11 167 septa septum NOUN fnp-9165 11 168 ; ; PUNCT fnp-9165 11 169 not not PART fnp-9165 11 170 in in ADP fnp-9165 11 171 corticospinal corticospinal ADJ fnp-9165 11 172 fasciculi fasciculi PROPN fnp-9165 11 173 caudal caudal NOUN fnp-9165 11 174 to to ADP fnp-9165 11 175 internal internal ADJ fnp-9165 11 176 capsule capsule NOUN fnp-9165 11 177 abstract abstract NOUN fnp-9165 11 178     SPACE fnp-9165 11 179 15 15 NUM fnp-9165 11 180 : : PUNCT fnp-9165 11 181 chromogenic chromogenic ADJ fnp-9165 11 182 in in ADP fnp-9165 11 183 situ situ ADJ fnp-9165 11 184 hybridization hybridization NOUN fnp-9165 11 185 for for ADP fnp-9165 11 186 detection detection NOUN fnp-9165 11 187 of of ADP fnp-9165 11 188 cdkn2a cdkn2a PROPN fnp-9165 11 189 / / SYM fnp-9165 11 190 b b NOUN fnp-9165 11 191 homozygous homozygous ADJ fnp-9165 11 192 deletion deletion NOUN fnp-9165 11 193 abstract abstract NOUN fnp-9165 11 194     SPACE fnp-9165 11 195 16 16 NUM fnp-9165 11 196 : : PUNCT fnp-9165 11 197 routine routine ADJ fnp-9165 11 198 immunohistochemical immunohistochemical ADJ fnp-9165 11 199 assessment assessment NOUN fnp-9165 11 200 of of ADP fnp-9165 11 201 mismatch mismatch ADJ fnp-9165 11 202 repair repair NOUN fnp-9165 11 203 proteins protein NOUN fnp-9165 11 204 in in ADP fnp-9165 11 205 high high ADJ fnp-9165 11 206 - - PUNCT fnp-9165 11 207 grade grade NOUN fnp-9165 11 208 gliomas glioma NOUN fnp-9165 11 209 : : PUNCT fnp-9165 11 210 retrospective retrospective ADJ fnp-9165 11 211 analysis analysis NOUN fnp-9165 11 212 and and CCONJ fnp-9165 11 213 clinical clinical ADJ fnp-9165 11 214 implications implication NOUN fnp-9165 11 215 abstract abstract ADJ fnp-9165 11 216     SPACE fnp-9165 11 217 17 17 NUM fnp-9165 11 218 : : PUNCT fnp-9165 11 219 malignant malignant ADJ fnp-9165 11 220 transformation transformation NOUN fnp-9165 11 221 of of ADP fnp-9165 11 222 craniopharyngioma craniopharyngioma NOUN fnp-9165 11 223 with with ADP fnp-9165 11 224 spinal spinal ADJ fnp-9165 11 225 metastasis metastasis NOUN fnp-9165 11 226 : : PUNCT fnp-9165 11 227 a a DET fnp-9165 11 228 case case NOUN fnp-9165 11 229 report report NOUN fnp-9165 11 230 and and CCONJ fnp-9165 11 231 comprehensive comprehensive ADJ fnp-9165 11 232 literature literature NOUN fnp-9165 11 233 review review PROPN fnp-9165 11 234 abstract abstract NOUN fnp-9165 11 235     SPACE fnp-9165 11 236 18 18 NUM fnp-9165 11 237 : : PUNCT fnp-9165 11 238 methylation methylation NOUN fnp-9165 11 239 classification classification NOUN fnp-9165 11 240 in in ADP fnp-9165 11 241 meningioma meningioma NOUN fnp-9165 11 242 prognostication prognostication NOUN fnp-9165 11 243 : : PUNCT fnp-9165 11 244 strengths strength NOUN fnp-9165 11 245 and and CCONJ fnp-9165 11 246 caveats caveat NOUN fnp-9165 11 247 abstract abstract ADJ fnp-9165 11 248     SPACE fnp-9165 11 249 19 19 NUM fnp-9165 11 250 : : PUNCT fnp-9165 11 251 liquid liquid ADJ fnp-9165 11 252 biopsy biopsy NOUN fnp-9165 11 253 for for ADP fnp-9165 11 254 cns cns PROPN fnp-9165 11 255 tumours tumours PROPN fnp-9165 11 256 abstract abstract NOUN fnp-9165 11 257     SPACE fnp-9165 11 258 20 20 NUM fnp-9165 11 259 : : PUNCT fnp-9165 11 260 pituitary pituitary ADJ fnp-9165 11 261 inflammatory inflammatory ADJ fnp-9165 11 262 lesions lesion NOUN fnp-9165 11 263 including include VERB fnp-9165 11 264 lymphocytic lymphocytic ADJ fnp-9165 11 265 hypophysitis hypophysitis NOUN fnp-9165 11 266 : : PUNCT fnp-9165 11 267 a a DET fnp-9165 11 268 30 30 NUM fnp-9165 11 269 - - PUNCT fnp-9165 11 270 year year NOUN fnp-9165 11 271 single single ADJ fnp-9165 11 272 centre centre NOUN fnp-9165 11 273 experience experience NOUN fnp-9165 11 274 abstract abstract NOUN fnp-9165 11 275     SPACE fnp-9165 11 276 21 21 NUM fnp-9165 11 277 : : PUNCT fnp-9165 11 278 additional additional ADJ fnp-9165 11 279 presence presence NOUN fnp-9165 11 280 of of ADP fnp-9165 11 281 lztr1 lztr1 PROPN fnp-9165 11 282 mutation mutation NOUN fnp-9165 11 283 in in ADP fnp-9165 11 284 a a DET fnp-9165 11 285 vgll vgll ADV fnp-9165 11 286 - - PUNCT fnp-9165 11 287 fused fuse VERB fnp-9165 11 288 central central ADJ fnp-9165 11 289 nervous nervous ADJ fnp-9165 11 290 system system NOUN fnp-9165 11 291 schwannoma schwannoma ADJ fnp-9165 11 292 with with ADP fnp-9165 11 293 neuroblastoma neuroblastoma NOUN fnp-9165 11 294 - - PUNCT fnp-9165 11 295 like like ADJ fnp-9165 11 296 cell cell NOUN fnp-9165 11 297 dense dense ADJ fnp-9165 11 298 areas area NOUN fnp-9165 11 299 abstract abstract ADJ fnp-9165 11 300     SPACE fnp-9165 11 301 22 22 NUM fnp-9165 11 302 : : PUNCT fnp-9165 11 303 histopathological histopathological ADJ fnp-9165 11 304 and and CCONJ fnp-9165 11 305 clinical clinical ADJ fnp-9165 11 306 features feature NOUN fnp-9165 11 307 can can AUX fnp-9165 11 308 discriminate discriminate VERB fnp-9165 11 309 immune immune ADJ fnp-9165 11 310 from from ADP fnp-9165 11 311 non non ADJ fnp-9165 11 312 - - ADJ fnp-9165 11 313 immune immune ADJ fnp-9165 11 314 statin statin NOUN fnp-9165 11 315 - - PUNCT fnp-9165 11 316 induced induce VERB fnp-9165 11 317 myotoxicity myotoxicity NOUN fnp-9165 11 318 abstract abstract NOUN fnp-9165 11 319     SPACE fnp-9165 11 320 23 23 NUM fnp-9165 11 321 : : PUNCT fnp-9165 11 322 muscle muscle NOUN fnp-9165 11 323 biopsy biopsy NOUN fnp-9165 11 324 findings finding NOUN fnp-9165 11 325 in in ADP fnp-9165 11 326 an an DET fnp-9165 11 327 infant infant NOUN fnp-9165 11 328 with with ADP fnp-9165 11 329 arthrogryposis arthrogryposis NOUN fnp-9165 11 330 associated associate VERB fnp-9165 11 331 with with ADP fnp-9165 11 332 a a DET fnp-9165 11 333 thoc2 thoc2 NOUN fnp-9165 11 334 variant variant NOUN fnp-9165 11 335 : : PUNCT fnp-9165 11 336 a a DET fnp-9165 11 337 case case NOUN fnp-9165 11 338 report report NOUN fnp-9165 11 339         SPACE fnp-9165 11 340 abstract abstract ADJ fnp-9165 11 341 1 1 NUM fnp-9165 11 342 free free ADJ fnp-9165 11 343 neuropathol neuropathol NOUN fnp-9165 11 344 6:23:4 6:23:4 NUM fnp-9165 11 345 decoding decode VERB fnp-9165 11 346 the the DET fnp-9165 11 347 diseased diseased ADJ fnp-9165 11 348 brain brain NOUN fnp-9165 11 349 : : PUNCT fnp-9165 11 350 using use VERB fnp-9165 11 351 machine machine NOUN fnp-9165 11 352 learning learn VERB fnp-9165 11 353 to to PART fnp-9165 11 354 gain gain VERB fnp-9165 11 355 comprehensive comprehensive ADJ fnp-9165 11 356 understanding understanding NOUN fnp-9165 11 357 of of ADP fnp-9165 11 358 neurodegenerative neurodegenerative ADJ fnp-9165 11 359 diseases disease NOUN fnp-9165 11 360 ain ain PROPN fnp-9165 11 361 kim1 kim1 PROPN fnp-9165 11 362 , , PUNCT fnp-9165 11 363 shelley shelley PROPN fnp-9165 11 364 l. l. PROPN fnp-9165 11 365 forrest1,2 forrest1,2 PROPN fnp-9165 11 366 , , PUNCT fnp-9165 11 367 gabor gabor PROPN fnp-9165 11 368 g. g. PROPN fnp-9165 11 369 kovacs1–7 kovacs1–7 PROPN fnp-9165 11 370 tanz tanz PROPN fnp-9165 11 371 center center NOUN fnp-9165 11 372 for for ADP fnp-9165 11 373 research research NOUN fnp-9165 11 374 in in ADP fnp-9165 11 375 neurodegenerative neurodegenerative ADJ fnp-9165 11 376 diseases disease NOUN fnp-9165 11 377 , , PUNCT fnp-9165 11 378 university university NOUN fnp-9165 11 379 of of ADP fnp-9165 11 380 toronto toronto PROPN fnp-9165 11 381 , , PUNCT fnp-9165 11 382 toronto toronto PROPN fnp-9165 11 383 , , PUNCT fnp-9165 11 384 canada canada PROPN fnp-9165 11 385 krembil krembil PROPN fnp-9165 11 386 brain brain PROPN fnp-9165 11 387 institute institute PROPN fnp-9165 11 388 , , PUNCT fnp-9165 11 389 university university NOUN fnp-9165 11 390 health health NOUN fnp-9165 11 391 network network NOUN fnp-9165 11 392 , , PUNCT fnp-9165 11 393 toronto toronto PROPN fnp-9165 11 394 , , PUNCT fnp-9165 11 395 canada canada PROPN fnp-9165 11 396 rossy rossy PROPN fnp-9165 11 397 centre centre PROPN fnp-9165 11 398 for for ADP fnp-9165 11 399 psp psp NOUN fnp-9165 11 400 , , PUNCT fnp-9165 11 401 toronto toronto PROPN fnp-9165 11 402 western western PROPN fnp-9165 11 403 hospital hospital PROPN fnp-9165 11 404 , , PUNCT fnp-9165 11 405 toronto toronto PROPN fnp-9165 11 406 , , PUNCT fnp-9165 11 407 canada canada PROPN fnp-9165 11 408 edmond edmond PROPN fnp-9165 11 409 j. j. PROPN fnp-9165 11 410 safra safra PROPN fnp-9165 11 411 program program PROPN fnp-9165 11 412 in in ADP fnp-9165 11 413 parkinson parkinson NOUN fnp-9165 11 414 ’s ’s PART fnp-9165 11 415 disease disease NOUN fnp-9165 11 416 and and CCONJ fnp-9165 11 417 the the DET fnp-9165 11 418 morton morton PROPN fnp-9165 11 419 and and CCONJ fnp-9165 11 420 gloria gloria PROPN fnp-9165 11 421 shulman shulman PROPN fnp-9165 11 422 movement movement PROPN fnp-9165 11 423 disorders disorder NOUN fnp-9165 11 424 clinic clinic PROPN fnp-9165 11 425 , , PUNCT fnp-9165 11 426 toronto toronto PROPN fnp-9165 11 427 western western PROPN fnp-9165 11 428 hospital hospital PROPN fnp-9165 11 429 , , PUNCT fnp-9165 11 430 toronto toronto PROPN fnp-9165 11 431 , , PUNCT fnp-9165 11 432 canada canada PROPN fnp-9165 11 433 division division NOUN fnp-9165 11 434 of of ADP fnp-9165 11 435 neurology neurology NOUN fnp-9165 11 436 , , PUNCT fnp-9165 11 437 university university PROPN fnp-9165 11 438 of of ADP fnp-9165 11 439 toronto toronto PROPN fnp-9165 11 440 , , PUNCT fnp-9165 11 441 toronto toronto PROPN fnp-9165 11 442 , , PUNCT fnp-9165 11 443 canada canada PROPN fnp-9165 11 444 laboratory laboratory PROPN fnp-9165 11 445 medicine medicine PROPN fnp-9165 11 446 program program NOUN fnp-9165 11 447 , , PUNCT fnp-9165 11 448 university university NOUN fnp-9165 11 449 health health NOUN fnp-9165 11 450 network network NOUN fnp-9165 11 451 , , PUNCT fnp-9165 11 452 toronto toronto PROPN fnp-9165 11 453 , , PUNCT fnp-9165 11 454 canada canada PROPN fnp-9165 11 455 department department PROPN fnp-9165 11 456 of of ADP fnp-9165 11 457 laboratory laboratory PROPN fnp-9165 11 458 medicine medicine PROPN fnp-9165 11 459 & & CCONJ fnp-9165 11 460 pathobiology pathobiology NOUN fnp-9165 11 461 , , PUNCT fnp-9165 11 462 university university PROPN fnp-9165 11 463 of of ADP fnp-9165 11 464 toronto toronto PROPN fnp-9165 11 465 , , PUNCT fnp-9165 11 466 toronto toronto PROPN fnp-9165 11 467 , , PUNCT fnp-9165 11 468 canada canada PROPN fnp-9165 11 469 neurodegenerative neurodegenerative ADJ fnp-9165 11 470 diseases disease NOUN fnp-9165 11 471 are be AUX fnp-9165 11 472 characterized characterize VERB fnp-9165 11 473 by by ADP fnp-9165 11 474 neuronal neuronal ADJ fnp-9165 11 475 loss loss NOUN fnp-9165 11 476 and and CCONJ fnp-9165 11 477 deposition deposition NOUN fnp-9165 11 478 of of ADP fnp-9165 11 479 misfolded misfolde VERB fnp-9165 11 480 proteins protein NOUN fnp-9165 11 481 in in ADP fnp-9165 11 482 the the DET fnp-9165 11 483 human human ADJ fnp-9165 11 484 brain brain NOUN fnp-9165 11 485 . . PUNCT fnp-9165 12 1 since since SCONJ fnp-9165 12 2 neuropathological neuropathological ADJ fnp-9165 12 3 evaluation evaluation NOUN fnp-9165 12 4 remains remain VERB fnp-9165 12 5 the the DET fnp-9165 12 6 gold gold ADJ fnp-9165 12 7 standard standard NOUN fnp-9165 12 8 for for ADP fnp-9165 12 9 definitive definitive ADJ fnp-9165 12 10 diagnosis diagnosis NOUN fnp-9165 12 11 , , PUNCT fnp-9165 12 12 many many ADJ fnp-9165 12 13 efforts effort NOUN fnp-9165 12 14 have have AUX fnp-9165 12 15 been be AUX fnp-9165 12 16 made make VERB fnp-9165 12 17 to to PART fnp-9165 12 18 understand understand VERB fnp-9165 12 19 the the DET fnp-9165 12 20 complex complex ADJ fnp-9165 12 21 neuropathological neuropathological ADJ fnp-9165 12 22 and and CCONJ fnp-9165 12 23 molecular molecular ADJ fnp-9165 12 24 changes change NOUN fnp-9165 12 25 underlying underlie VERB fnp-9165 12 26 neurodegenerative neurodegenerative ADJ fnp-9165 12 27 diseases disease NOUN fnp-9165 12 28 using use VERB fnp-9165 12 29 fully fully ADV fnp-9165 12 30 characterized characterize VERB fnp-9165 12 31 post post ADJ fnp-9165 12 32 - - ADJ fnp-9165 12 33 mortem mortem ADJ fnp-9165 12 34 tissues tissue NOUN fnp-9165 12 35 . . PUNCT fnp-9165 13 1 these these PRON fnp-9165 13 2 include include VERB fnp-9165 13 3 evaluating evaluate VERB fnp-9165 13 4 cytopathologies cytopathologie NOUN fnp-9165 13 5 , , PUNCT fnp-9165 13 6 morphologies morphology NOUN fnp-9165 13 7 of of ADP fnp-9165 13 8 pathological pathological ADJ fnp-9165 13 9 inclusions inclusion NOUN fnp-9165 13 10 , , PUNCT fnp-9165 13 11 biochemical biochemical ADJ fnp-9165 13 12 properties property NOUN fnp-9165 13 13 of of ADP fnp-9165 13 14 misfolded misfolded ADJ fnp-9165 13 15 proteins protein NOUN fnp-9165 13 16 using use VERB fnp-9165 13 17 seed seed NOUN fnp-9165 13 18 amplification amplification NOUN fnp-9165 13 19 assays assay NOUN fnp-9165 13 20 ( ( PUNCT fnp-9165 13 21 saa saa PROPN fnp-9165 13 22 ) ) PUNCT fnp-9165 13 23 , , PUNCT fnp-9165 13 24 and and CCONJ fnp-9165 13 25 genotypic genotypic NOUN fnp-9165 13 26 information information NOUN fnp-9165 13 27 . . PUNCT fnp-9165 14 1 however however ADV fnp-9165 14 2 , , PUNCT fnp-9165 14 3 the the DET fnp-9165 14 4 results result NOUN fnp-9165 14 5 of of ADP fnp-9165 14 6 these these DET fnp-9165 14 7 evaluations evaluation NOUN fnp-9165 14 8 are be AUX fnp-9165 14 9 not not PART fnp-9165 14 10 independent independent ADJ fnp-9165 14 11 , , PUNCT fnp-9165 14 12 but but CCONJ fnp-9165 14 13 rather rather ADV fnp-9165 14 14 should should AUX fnp-9165 14 15 be be AUX fnp-9165 14 16 interpreted interpret VERB fnp-9165 14 17 together together ADV fnp-9165 14 18 . . PUNCT fnp-9165 15 1 in in ADP fnp-9165 15 2 order order NOUN fnp-9165 15 3 to to PART fnp-9165 15 4 integrate integrate VERB fnp-9165 15 5 results result NOUN fnp-9165 15 6 from from ADP fnp-9165 15 7 multiple multiple ADJ fnp-9165 15 8 disciplines discipline NOUN fnp-9165 15 9 and and CCONJ fnp-9165 15 10 achieve achieve VERB fnp-9165 15 11 a a DET fnp-9165 15 12 comprehensive comprehensive ADJ fnp-9165 15 13 understanding understanding NOUN fnp-9165 15 14 of of ADP fnp-9165 15 15 the the DET fnp-9165 15 16 disease disease NOUN fnp-9165 15 17 , , PUNCT fnp-9165 15 18 a a DET fnp-9165 15 19 powerful powerful ADJ fnp-9165 15 20 and and CCONJ fnp-9165 15 21 scalable scalable ADJ fnp-9165 15 22 tool tool NOUN fnp-9165 15 23 is be AUX fnp-9165 15 24 needed need VERB fnp-9165 15 25 . . PUNCT fnp-9165 16 1 we we PRON fnp-9165 16 2 used use VERB fnp-9165 16 3 machine machine NOUN fnp-9165 16 4 learning learning NOUN fnp-9165 16 5 , , PUNCT fnp-9165 16 6 a a DET fnp-9165 16 7 branch branch NOUN fnp-9165 16 8 of of ADP fnp-9165 16 9 artificial artificial ADJ fnp-9165 16 10 intelligence intelligence NOUN fnp-9165 16 11 , , PUNCT fnp-9165 16 12 to to PART fnp-9165 16 13 learn learn VERB fnp-9165 16 14 latent latent NOUN fnp-9165 16 15 patterns pattern NOUN fnp-9165 16 16 from from ADP fnp-9165 16 17 high high ADJ fnp-9165 16 18 dimensional dimensional ADJ fnp-9165 16 19 data datum NOUN fnp-9165 16 20 and and CCONJ fnp-9165 16 21 incorporate incorporate VERB fnp-9165 16 22 results result NOUN fnp-9165 16 23 from from ADP fnp-9165 16 24 multiple multiple ADJ fnp-9165 16 25 disciplines discipline NOUN fnp-9165 16 26 . . PUNCT fnp-9165 17 1 machine machine NOUN fnp-9165 17 2 learning learning NOUN fnp-9165 17 3 - - PUNCT fnp-9165 17 4 based base VERB fnp-9165 17 5 analysis analysis NOUN fnp-9165 17 6 has have AUX fnp-9165 17 7 allowed allow VERB fnp-9165 17 8 : : PUNCT fnp-9165 17 9 i i PRON fnp-9165 17 10 ) ) PUNCT fnp-9165 17 11 the the DET fnp-9165 17 12 discovery discovery NOUN fnp-9165 17 13 of of ADP fnp-9165 17 14 novel novel ADJ fnp-9165 17 15 subtypes subtype NOUN fnp-9165 17 16 of of ADP fnp-9165 17 17 multiple multiple ADJ fnp-9165 17 18 system system NOUN fnp-9165 17 19 atrophy atrophy NOUN fnp-9165 17 20 based base VERB fnp-9165 17 21 on on ADP fnp-9165 17 22 morphological morphological ADJ fnp-9165 17 23 variables variable NOUN fnp-9165 17 24 , , PUNCT fnp-9165 17 25 ii ii NOUN fnp-9165 17 26 ) ) PUNCT fnp-9165 17 27 the the DET fnp-9165 17 28 integration integration NOUN fnp-9165 17 29 of of ADP fnp-9165 17 30 alph alph VERB fnp-9165 17 31 α α PROPN fnp-9165 17 32 - - PUNCT fnp-9165 17 33 synuclein synuclein NOUN fnp-9165 17 34 cytopathology cytopathology NOUN fnp-9165 17 35 and and CCONJ fnp-9165 17 36 seeding seed VERB fnp-9165 17 37 behavior behavior NOUN fnp-9165 17 38 to to PART fnp-9165 17 39 describe describe VERB fnp-9165 17 40 cell cell NOUN fnp-9165 17 41 type type NOUN fnp-9165 17 42 - - PUNCT fnp-9165 17 43 specific specific ADJ fnp-9165 17 44 seeding seeding NOUN fnp-9165 17 45 in in ADP fnp-9165 17 46 synucleinopathies synucleinopathie NOUN fnp-9165 17 47 , , PUNCT fnp-9165 17 48 iii iii NOUN fnp-9165 17 49 ) ) PUNCT fnp-9165 17 50 the the DET fnp-9165 17 51 understanding understanding NOUN fnp-9165 17 52 of of ADP fnp-9165 17 53 differences difference NOUN fnp-9165 17 54 in in ADP fnp-9165 17 55 in in ADP fnp-9165 17 56 inflammatory inflammatory ADJ fnp-9165 17 57 markers marker NOUN fnp-9165 17 58 of of ADP fnp-9165 17 59 distinct distinct ADJ fnp-9165 17 60 inheritable inheritable ADJ fnp-9165 17 61 dna dna NOUN fnp-9165 17 62 sequence sequence NOUN fnp-9165 17 63 patterns pattern NOUN fnp-9165 17 64 , , PUNCT fnp-9165 17 65 iv iv X fnp-9165 17 66 ) ) PUNCT fnp-9165 17 67 the the DET fnp-9165 17 68 validation validation NOUN fnp-9165 17 69 of of ADP fnp-9165 17 70 subtype subtype NOUN fnp-9165 17 71 and and CCONJ fnp-9165 17 72 staging staging NOUN fnp-9165 17 73 in in ADP fnp-9165 17 74 progressive progressive ADJ fnp-9165 17 75 supranuclear supranuclear ADJ fnp-9165 17 76 palsy palsy ADJ fnp-9165 17 77 , , PUNCT fnp-9165 17 78 and and CCONJ fnp-9165 17 79 v v NOUN fnp-9165 17 80 ) ) PUNCT fnp-9165 17 81 the the DET fnp-9165 17 82 prediction prediction NOUN fnp-9165 17 83 of of ADP fnp-9165 17 84 4r 4r NOUN fnp-9165 17 85 - - PUNCT fnp-9165 17 86 tauopathies tauopathie NOUN fnp-9165 17 87 using use VERB fnp-9165 17 88 morphological morphological ADJ fnp-9165 17 89 differences difference NOUN fnp-9165 17 90 in in ADP fnp-9165 17 91 coiled coil VERB fnp-9165 17 92 bodies body NOUN fnp-9165 17 93 . . PUNCT fnp-9165 18 1 machine machine NOUN fnp-9165 18 2 learning learning NOUN fnp-9165 18 3 can can AUX fnp-9165 18 4 be be AUX fnp-9165 18 5 applied apply VERB fnp-9165 18 6 not not PART fnp-9165 18 7 only only ADV fnp-9165 18 8 for for ADP fnp-9165 18 9 diagnostic diagnostic ADJ fnp-9165 18 10 predictions prediction NOUN fnp-9165 18 11 in in ADP fnp-9165 18 12 clinical clinical ADJ fnp-9165 18 13 settings setting NOUN fnp-9165 18 14 , , PUNCT fnp-9165 18 15 but but CCONJ fnp-9165 18 16 also also ADV fnp-9165 18 17 as as SCONJ fnp-9165 18 18 a a DET fnp-9165 18 19 research research NOUN fnp-9165 18 20 tool tool NOUN fnp-9165 18 21 to to PART fnp-9165 18 22 understand understand VERB fnp-9165 18 23 the the DET fnp-9165 18 24 comprehensive comprehensive ADJ fnp-9165 18 25 biological biological ADJ fnp-9165 18 26 underpinnings underpinning NOUN fnp-9165 18 27 of of ADP fnp-9165 18 28 neurodegenerative neurodegenerative ADJ fnp-9165 18 29 disease disease NOUN fnp-9165 18 30 . . PUNCT fnp-9165 18 31     SPACE fnp-9165 19 1 abstract abstract ADJ fnp-9165 19 2 2 2 NUM fnp-9165 19 3 free free ADJ fnp-9165 19 4 neuropathol neuropathol NOUN fnp-9165 19 5 6:23:5 6:23:5 NUM fnp-9165 19 6 the the DET fnp-9165 19 7 relevance relevance NOUN fnp-9165 19 8 of of ADP fnp-9165 19 9 identifying identify VERB fnp-9165 19 10 limbic limbic ADJ fnp-9165 19 11 neuronal neuronal ADJ fnp-9165 19 12 synuclein synuclein NOUN fnp-9165 19 13 pathology pathology NOUN fnp-9165 19 14 in in ADP fnp-9165 19 15 multiple multiple ADJ fnp-9165 19 16 system system NOUN fnp-9165 19 17 atrophy atrophy NOUN fnp-9165 19 18 gabor gabor PROPN fnp-9165 19 19 g. g. PROPN fnp-9165 19 20 kovacs1–6 kovacs1–6 PROPN fnp-9165 19 21 , , PUNCT fnp-9165 19 22 ivan ivan PROPN fnp-9165 19 23 martinez martinez PROPN fnp-9165 19 24 - - PUNCT fnp-9165 19 25 valbuena1 valbuena1 PROPN fnp-9165 19 26 , , PUNCT fnp-9165 19 27 shelley shelley PROPN fnp-9165 19 28 l. l. PROPN fnp-9165 19 29 forrest1 forrest1 PROPN fnp-9165 19 30 , , PUNCT fnp-9165 19 31 xiaoxiao xiaoxiao PROPN fnp-9165 19 32 xu6 xu6 PROPN fnp-9165 19 33 , , PUNCT fnp-9165 19 34 renato renato PROPN fnp-9165 19 35 p. p. PROPN fnp-9165 19 36 munhoz5 munhoz5 PROPN fnp-9165 19 37 , , PUNCT fnp-9165 19 38 jun jun PROPN fnp-9165 19 39 li1 li1 PROPN fnp-9165 19 40 , , PUNCT fnp-9165 19 41 ekaterina ekaterina PROPN fnp-9165 19 42 rogaeva1 rogaeva1 PROPN fnp-9165 19 43 , , PUNCT fnp-9165 19 44 anthony anthony PROPN fnp-9165 19 45 e. e. PROPN fnp-9165 19 46 lang5 lang5 PROPN fnp-9165 19 47 , , PUNCT fnp-9165 19 48 masahiro masahiro PROPN fnp-9165 19 49 enomoto7 enomoto7 PROPN fnp-9165 20 1 tanz tanz PROPN fnp-9165 20 2 center center NOUN fnp-9165 20 3 for for ADP fnp-9165 20 4 research research NOUN fnp-9165 20 5 in in ADP fnp-9165 20 6 neurodegenerative neurodegenerative ADJ fnp-9165 20 7 diseases disease NOUN fnp-9165 20 8 , , PUNCT fnp-9165 20 9 university university NOUN fnp-9165 20 10 of of ADP fnp-9165 20 11 toronto toronto PROPN fnp-9165 20 12 , , PUNCT fnp-9165 20 13 toronto toronto PROPN fnp-9165 20 14 , , PUNCT fnp-9165 20 15 canada canada PROPN fnp-9165 20 16 krembil krembil PROPN fnp-9165 20 17 brain brain PROPN fnp-9165 20 18 institute institute PROPN fnp-9165 20 19 , , PUNCT fnp-9165 20 20 university university NOUN fnp-9165 20 21 health health NOUN fnp-9165 20 22 network network NOUN fnp-9165 20 23 , , PUNCT fnp-9165 20 24 toronto toronto PROPN fnp-9165 20 25 , , PUNCT fnp-9165 20 26 canada canada PROPN fnp-9165 20 27 department department PROPN fnp-9165 20 28 of of ADP fnp-9165 20 29 laboratory laboratory NOUN fnp-9165 20 30 medicine medicine NOUN fnp-9165 20 31 and and CCONJ fnp-9165 20 32 pathobiology pathobiology NOUN fnp-9165 20 33 , , PUNCT fnp-9165 20 34 university university PROPN fnp-9165 20 35 of of ADP fnp-9165 20 36 toronto toronto PROPN fnp-9165 20 37 , , PUNCT fnp-9165 20 38 toronto toronto PROPN fnp-9165 20 39 , , PUNCT fnp-9165 20 40 canada canada PROPN fnp-9165 20 41 laboratory laboratory PROPN fnp-9165 20 42 medicine medicine PROPN fnp-9165 20 43 program program NOUN fnp-9165 20 44 , , PUNCT fnp-9165 20 45 university university NOUN fnp-9165 20 46 health health NOUN fnp-9165 20 47 network network NOUN fnp-9165 20 48 , , PUNCT fnp-9165 20 49 toronto toronto PROPN fnp-9165 20 50 , , PUNCT fnp-9165 20 51 canada canada PROPN fnp-9165 20 52 edmond edmond PROPN fnp-9165 20 53 j. j. PROPN fnp-9165 20 54 safra safra PROPN fnp-9165 20 55 program program PROPN fnp-9165 20 56 in in ADP fnp-9165 20 57 parkinson parkinson NOUN fnp-9165 20 58 ’s ’s PART fnp-9165 20 59 disease disease NOUN fnp-9165 20 60 and and CCONJ fnp-9165 20 61 the the DET fnp-9165 20 62 morton morton PROPN fnp-9165 20 63 and and CCONJ fnp-9165 20 64 gloria gloria PROPN fnp-9165 20 65 shulman shulman PROPN fnp-9165 20 66 movement movement PROPN fnp-9165 20 67 disorders disorder NOUN fnp-9165 20 68 clinic clinic PROPN fnp-9165 20 69 , , PUNCT fnp-9165 20 70 toronto toronto PROPN fnp-9165 20 71 western western PROPN fnp-9165 20 72 hospital hospital PROPN fnp-9165 20 73 , , PUNCT fnp-9165 20 74 toronto toronto PROPN fnp-9165 20 75 , , PUNCT fnp-9165 20 76 canada canada PROPN fnp-9165 20 77 department department PROPN fnp-9165 20 78 of of ADP fnp-9165 20 79 medical medical ADJ fnp-9165 20 80 biophysics biophysic NOUN fnp-9165 20 81 , , PUNCT fnp-9165 20 82 university university PROPN fnp-9165 20 83 of of ADP fnp-9165 20 84 toronto toronto PROPN fnp-9165 20 85 , , PUNCT fnp-9165 20 86 toronto toronto PROPN fnp-9165 20 87 , , PUNCT fnp-9165 20 88 canada canada PROPN fnp-9165 20 89 princess princess PROPN fnp-9165 20 90 margaret margaret PROPN fnp-9165 20 91 cancer cancer PROPN fnp-9165 20 92 centre centre PROPN fnp-9165 20 93 , , PUNCT fnp-9165 20 94 university university NOUN fnp-9165 20 95 health health NOUN fnp-9165 20 96 network network NOUN fnp-9165 20 97 , , PUNCT fnp-9165 20 98 toronto toronto PROPN fnp-9165 20 99 , , PUNCT fnp-9165 20 100 canada canada PROPN fnp-9165 20 101 two two NUM fnp-9165 20 102 neuropathologically neuropathologically ADV fnp-9165 20 103 defined define VERB fnp-9165 20 104 disorders disorder NOUN fnp-9165 20 105 that that PRON fnp-9165 20 106 show show VERB fnp-9165 20 107 consistently consistently ADV fnp-9165 20 108 α α NUM fnp-9165 20 109 - - PUNCT fnp-9165 20 110 synuclein synuclein ADJ fnp-9165 20 111 pathology pathology NOUN fnp-9165 20 112 include include VERB fnp-9165 20 113 lewy lewy PROPN fnp-9165 20 114 body body NOUN fnp-9165 20 115 diseases disease NOUN fnp-9165 20 116 ( ( PUNCT fnp-9165 20 117 lbd lbd PROPN fnp-9165 20 118 ) ) PUNCT fnp-9165 20 119 and and CCONJ fnp-9165 20 120 multiple multiple ADJ fnp-9165 20 121 system system NOUN fnp-9165 20 122 atrophy atrophy NOUN fnp-9165 20 123 ( ( PUNCT fnp-9165 20 124 msa msa PROPN fnp-9165 20 125 ) ) PUNCT fnp-9165 20 126 . . PUNCT fnp-9165 21 1 msa msa PROPN fnp-9165 21 2 is be AUX fnp-9165 21 3 characterized characterize VERB fnp-9165 21 4 by by ADP fnp-9165 21 5 predominantly predominantly ADV fnp-9165 21 6 oligodendroglial oligodendroglial ADJ fnp-9165 21 7 cytoplasmic cytoplasmic ADJ fnp-9165 21 8 inclusions inclusion NOUN fnp-9165 21 9 and and CCONJ fnp-9165 21 10 distinct distinct ADJ fnp-9165 21 11 synuclein synuclein NOUN fnp-9165 21 12 protofilament protofilament ADJ fnp-9165 21 13 folds fold NOUN fnp-9165 21 14 . . PUNCT fnp-9165 22 1 to to PART fnp-9165 22 2 compare compare VERB fnp-9165 22 3 literature literature NOUN fnp-9165 22 4 observations observation NOUN fnp-9165 22 5 on on ADP fnp-9165 22 6 hippocampal hippocampal ADJ fnp-9165 22 7 neuronal neuronal ADJ fnp-9165 22 8 synuclein synuclein NOUN fnp-9165 22 9 pathology pathology NOUN fnp-9165 22 10 in in ADP fnp-9165 22 11 msa msa PROPN fnp-9165 22 12 and and CCONJ fnp-9165 22 13 to to PART fnp-9165 22 14 address address VERB fnp-9165 22 15 the the DET fnp-9165 22 16 question question NOUN fnp-9165 22 17 whether whether SCONJ fnp-9165 22 18 brain brain NOUN fnp-9165 22 19 regions region NOUN fnp-9165 22 20 showing show VERB fnp-9165 22 21 unusual unusual ADJ fnp-9165 22 22 neuronal neuronal ADJ fnp-9165 22 23 α α NOUN fnp-9165 22 24 - - PUNCT fnp-9165 22 25 synuclein synuclein NOUN fnp-9165 22 26 pathology pathology NOUN fnp-9165 22 27 are be AUX fnp-9165 22 28 associated associate VERB fnp-9165 22 29 with with ADP fnp-9165 22 30 distinct distinct ADJ fnp-9165 22 31 biochemical biochemical ADJ fnp-9165 22 32 and and CCONJ fnp-9165 22 33 structural structural ADJ fnp-9165 22 34 profile profile NOUN fnp-9165 22 35 of of ADP fnp-9165 22 36 α α NOUN fnp-9165 22 37 - - PUNCT fnp-9165 22 38 synuclein synuclein NOUN fnp-9165 22 39 as as ADP fnp-9165 22 40 a a DET fnp-9165 22 41 distinctive distinctive ADJ fnp-9165 22 42 feature feature NOUN fnp-9165 22 43 of of ADP fnp-9165 22 44 atypical atypical ADJ fnp-9165 22 45 form form NOUN fnp-9165 22 46 of of ADP fnp-9165 22 47 msa msa PROPN fnp-9165 22 48 . . PUNCT fnp-9165 23 1 literature literature PROPN fnp-9165 23 2 overview overview NOUN fnp-9165 23 3 of of ADP fnp-9165 23 4 msa msa PROPN fnp-9165 23 5 with with ADP fnp-9165 23 6 limbic limbic ADJ fnp-9165 23 7 neuronal neuronal ADJ fnp-9165 23 8 synuclein synuclein NOUN fnp-9165 23 9 pathology pathology NOUN fnp-9165 23 10 ( ( PUNCT fnp-9165 23 11 atypical atypical PROPN fnp-9165 23 12 msa msa PROPN fnp-9165 23 13 ) ) PUNCT fnp-9165 23 14 . . PUNCT fnp-9165 24 1 report report NOUN fnp-9165 24 2 of of ADP fnp-9165 24 3 a a DET fnp-9165 24 4 case case NOUN fnp-9165 24 5 and and CCONJ fnp-9165 24 6 comparison comparison NOUN fnp-9165 24 7 with with ADP fnp-9165 24 8 typical typical ADJ fnp-9165 24 9 cases case NOUN fnp-9165 24 10 of of ADP fnp-9165 24 11 msa msa PROPN fnp-9165 24 12 using use VERB fnp-9165 24 13 α α PROPN fnp-9165 24 14 - - PUNCT fnp-9165 24 15 synuclein synuclein NOUN fnp-9165 24 16 seed seed NOUN fnp-9165 24 17 amplification amplification NOUN fnp-9165 24 18 assay assay NOUN fnp-9165 24 19 ( ( PUNCT fnp-9165 24 20 α α NOUN fnp-9165 24 21 - - PUNCT fnp-9165 24 22 syn syn PROPN fnp-9165 24 23 saa saa PROPN fnp-9165 24 24 ) ) PUNCT fnp-9165 24 25 , , PUNCT fnp-9165 24 26 immunoblotting immunoblotte VERB fnp-9165 24 27 , , PUNCT fnp-9165 24 28 proteinase proteinase NOUN fnp-9165 24 29 k k NOUN fnp-9165 24 30 digestions digestion NOUN fnp-9165 24 31 , , PUNCT fnp-9165 24 32 conformational conformational ADJ fnp-9165 24 33 stability stability NOUN fnp-9165 24 34 assay assay PROPN fnp-9165 24 35 ( ( PUNCT fnp-9165 24 36 csa csa PROPN fnp-9165 24 37 ) ) PUNCT fnp-9165 24 38 and and CCONJ fnp-9165 24 39 electron electron VERB fnp-9165 24 40 cryo cryo NOUN fnp-9165 24 41 - - PUNCT fnp-9165 24 42 microscopy microscopy NOUN fnp-9165 24 43 . . PUNCT fnp-9165 25 1 neuronal neuronal ADJ fnp-9165 25 2 cytoplasmic cytoplasmic ADJ fnp-9165 25 3 inclusions inclusion NOUN fnp-9165 25 4 are be AUX fnp-9165 25 5 thought think VERB fnp-9165 25 6 to to PART fnp-9165 25 7 contribute contribute VERB fnp-9165 25 8 to to ADP fnp-9165 25 9 memory memory NOUN fnp-9165 25 10 impairment impairment NOUN fnp-9165 25 11 when when SCONJ fnp-9165 25 12 seen see VERB fnp-9165 25 13 in in ADP fnp-9165 25 14 the the DET fnp-9165 25 15 hippocampus hippocampus NOUN fnp-9165 25 16 in in ADP fnp-9165 25 17 msa msa PROPN fnp-9165 25 18 and and CCONJ fnp-9165 25 19 additionally additionally ADV fnp-9165 25 20 large large ADJ fnp-9165 25 21 argyrophilic argyrophilic ADJ fnp-9165 25 22 neuronal neuronal ADJ fnp-9165 25 23 inclusions inclusion NOUN fnp-9165 25 24 are be AUX fnp-9165 25 25 detected detect VERB fnp-9165 25 26 in in ADP fnp-9165 25 27 atypical atypical PROPN fnp-9165 25 28 msa msa PROPN fnp-9165 25 29 . . PUNCT fnp-9165 26 1 in in ADP fnp-9165 26 2 our our PRON fnp-9165 26 3 case case NOUN fnp-9165 26 4 with with ADP fnp-9165 26 5 atypical atypical PROPN fnp-9165 26 6 msa msa PROPN fnp-9165 26 7 , , PUNCT fnp-9165 26 8 we we PRON fnp-9165 26 9 demonstrate demonstrate VERB fnp-9165 26 10 distinct distinct ADJ fnp-9165 26 11 biochemical biochemical ADJ fnp-9165 26 12 characteristics characteristic NOUN fnp-9165 26 13 of of ADP fnp-9165 26 14 α α PROPN fnp-9165 26 15 - - PUNCT fnp-9165 26 16 synuclein synuclein NOUN fnp-9165 26 17 linked link VERB fnp-9165 26 18 to to ADP fnp-9165 26 19 cytopathological cytopathological ADJ fnp-9165 26 20 differences difference NOUN fnp-9165 26 21 ( ( PUNCT fnp-9165 26 22 e.g. e.g. ADV fnp-9165 26 23 neuronal neuronal ADJ fnp-9165 26 24 or or CCONJ fnp-9165 26 25 oligodendroglial oligodendroglial ADJ fnp-9165 26 26 ) ) PUNCT fnp-9165 26 27 and and CCONJ fnp-9165 26 28 a a DET fnp-9165 26 29 new new ADJ fnp-9165 26 30 lewy lewy PROPN fnp-9165 26 31 - - PUNCT fnp-9165 26 32 msa msa PROPN fnp-9165 26 33 hybrid hybrid ADJ fnp-9165 26 34 fold fold ADJ fnp-9165 26 35 brain brain NOUN fnp-9165 26 36 regions region NOUN fnp-9165 26 37 showing show VERB fnp-9165 26 38 neuronal neuronal ADJ fnp-9165 26 39 inclusions inclusion NOUN fnp-9165 26 40 . . PUNCT fnp-9165 27 1 we we PRON fnp-9165 27 2 propose propose VERB fnp-9165 27 3 that that SCONJ fnp-9165 27 4 cell cell NOUN fnp-9165 27 5 - - PUNCT fnp-9165 27 6 specific specific ADJ fnp-9165 27 7 protein protein NOUN fnp-9165 27 8 pathologies pathology NOUN fnp-9165 27 9 can can AUX fnp-9165 27 10 be be AUX fnp-9165 27 11 associated associate VERB fnp-9165 27 12 with with ADP fnp-9165 27 13 distinct distinct ADJ fnp-9165 27 14 filament filament NOUN fnp-9165 27 15 folds fold NOUN fnp-9165 27 16 and and CCONJ fnp-9165 27 17 expand expand VERB fnp-9165 27 18 the the DET fnp-9165 27 19 current current ADJ fnp-9165 27 20 structure structure NOUN fnp-9165 27 21 - - PUNCT fnp-9165 27 22 based base VERB fnp-9165 27 23 classification classification NOUN fnp-9165 27 24 of of ADP fnp-9165 27 25 α α NOUN fnp-9165 27 26 - - NOUN fnp-9165 27 27 synucleinopathies synucleinopathie NOUN fnp-9165 27 28 . . PUNCT fnp-9165 27 29     SPACE fnp-9165 28 1 abstract abstract ADJ fnp-9165 28 2 3 3 NUM fnp-9165 28 3 free free ADJ fnp-9165 28 4 neuropathol neuropathol NOUN fnp-9165 28 5 6:23:6 6:23:6 NUM fnp-9165 28 6 spinal spinal ADJ fnp-9165 28 7 cord cord NOUN fnp-9165 28 8 α α NOUN fnp-9165 28 9 - - PUNCT fnp-9165 28 10 synuclein synuclein NOUN fnp-9165 28 11 mapping mapping NOUN fnp-9165 28 12 in in ADP fnp-9165 28 13 parkinson parkinson NOUN fnp-9165 28 14 ’s ’s PART fnp-9165 28 15 disease disease NOUN fnp-9165 28 16 pramath pramath PROPN fnp-9165 28 17 kakodkar1 kakodkar1 PROPN fnp-9165 28 18 , , PUNCT fnp-9165 28 19 javera javera PROPN fnp-9165 28 20 tariq1 tariq1 PROPN fnp-9165 28 21 , , PUNCT fnp-9165 29 1 ali ali PROPN fnp-9165 29 2 h. h. PROPN fnp-9165 29 3 rajput2 rajput2 PROPN fnp-9165 29 4 , , PUNCT fnp-9165 29 5 alex alex PROPN fnp-9165 29 6 rajput2 rajput2 PROPN fnp-9165 29 7 , , PUNCT fnp-9165 29 8 roland roland PROPN fnp-9165 29 9 n. n. PROPN fnp-9165 30 1 auer1 auer1 PROPN fnp-9165 31 1 department department PROPN fnp-9165 31 2 pathology pathology NOUN fnp-9165 31 3 and and CCONJ fnp-9165 31 4 lab lab NOUN fnp-9165 31 5 medicine medicine NOUN fnp-9165 31 6 , , PUNCT fnp-9165 31 7 university university PROPN fnp-9165 31 8 of of ADP fnp-9165 31 9 saskatchewan saskatchewan PROPN fnp-9165 31 10 , , PUNCT fnp-9165 31 11 saskatoon saskatoon PROPN fnp-9165 31 12 , , PUNCT fnp-9165 31 13 canada canada PROPN fnp-9165 31 14 neurology neurology NOUN fnp-9165 31 15 division division NOUN fnp-9165 31 16 , , PUNCT fnp-9165 31 17 university university PROPN fnp-9165 31 18 of of ADP fnp-9165 31 19 saskatchewan saskatchewan PROPN fnp-9165 31 20 , , PUNCT fnp-9165 31 21 saskatoon saskatoon PROPN fnp-9165 31 22 , , PUNCT fnp-9165 31 23 canada canada PROPN fnp-9165 31 24 it it PRON fnp-9165 31 25 has have AUX fnp-9165 31 26 been be AUX fnp-9165 31 27 hypothesized hypothesize VERB fnp-9165 31 28 that that SCONJ fnp-9165 31 29 the the DET fnp-9165 31 30 etiology etiology NOUN fnp-9165 31 31 of of ADP fnp-9165 31 32 parkinson parkinson NOUN fnp-9165 31 33 ’s ’s PART fnp-9165 31 34 disease disease NOUN fnp-9165 31 35 ( ( PUNCT fnp-9165 31 36 pd pd NOUN fnp-9165 31 37 ) ) PUNCT fnp-9165 31 38 lies lie VERB fnp-9165 31 39 outside outside ADP fnp-9165 31 40 the the DET fnp-9165 31 41 body body NOUN fnp-9165 31 42 via via ADP fnp-9165 31 43 an an DET fnp-9165 31 44 inhaled inhaled ADJ fnp-9165 31 45 / / SYM fnp-9165 31 46 swallowed swallow VERB fnp-9165 31 47 agent agent NOUN fnp-9165 31 48 entering enter VERB fnp-9165 31 49 the the DET fnp-9165 31 50 body body NOUN fnp-9165 31 51 to to PART fnp-9165 31 52 cause cause VERB fnp-9165 31 53 protein protein NOUN fnp-9165 31 54 - - PUNCT fnp-9165 31 55 catalyzed catalyze VERB fnp-9165 31 56 misfolding misfolding NOUN fnp-9165 31 57 of of ADP fnp-9165 31 58 proteins protein NOUN fnp-9165 31 59 akin akin ADJ fnp-9165 31 60 to to ADP fnp-9165 31 61 prion prion NOUN fnp-9165 31 62 diseases disease NOUN fnp-9165 31 63 . . PUNCT fnp-9165 32 1 early early ADJ fnp-9165 32 2 olfactory olfactory ADJ fnp-9165 32 3 abnormalities abnormality NOUN fnp-9165 32 4 and and CCONJ fnp-9165 32 5 gut gut NOUN fnp-9165 32 6 dysbiosis dysbiosis NOUN fnp-9165 32 7 antedate antedate VERB fnp-9165 32 8 a a DET fnp-9165 32 9 proposed propose VERB fnp-9165 32 10 march march NOUN fnp-9165 32 11 of of ADP fnp-9165 32 12 α α PROPN fnp-9165 32 13 - - PUNCT fnp-9165 32 14 synuclein synuclein NOUN fnp-9165 32 15 misfolding misfolde VERB fnp-9165 32 16 through through ADP fnp-9165 32 17 loci loci NOUN fnp-9165 32 18 involving involve VERB fnp-9165 32 19 olfactory olfactory ADJ fnp-9165 32 20 and and CCONJ fnp-9165 32 21 autonomic autonomic ADJ fnp-9165 32 22 systems system NOUN fnp-9165 32 23 in in ADP fnp-9165 32 24 a a DET fnp-9165 32 25 body body NOUN fnp-9165 32 26 - - PUNCT fnp-9165 32 27 first first ADV fnp-9165 32 28 , , PUNCT fnp-9165 32 29 not not PART fnp-9165 32 30 brain brain NOUN fnp-9165 32 31 - - PUNCT fnp-9165 32 32 first first ADJ fnp-9165 32 33 , , PUNCT fnp-9165 32 34 sequence sequence NOUN fnp-9165 32 35 . . PUNCT fnp-9165 33 1 using use VERB fnp-9165 33 2 anti anti ADJ fnp-9165 33 3 - - ADJ fnp-9165 33 4 phospho phospho ADJ fnp-9165 33 5 - - PUNCT fnp-9165 33 6 ser129 ser129 ADJ fnp-9165 33 7 α α PROPN fnp-9165 33 8 - - PUNCT fnp-9165 33 9 synuclein synuclein NOUN fnp-9165 33 10 antibodies antibody NOUN fnp-9165 33 11 and and CCONJ fnp-9165 33 12 an an DET fnp-9165 33 13 immunohistochemical immunohistochemical ADJ fnp-9165 33 14 red red ADJ fnp-9165 33 15 readout readout NOUN fnp-9165 33 16 , , PUNCT fnp-9165 33 17 we we PRON fnp-9165 33 18 mapped map VERB fnp-9165 33 19 α α PRON fnp-9165 33 20 - - PUNCT fnp-9165 33 21 synuclein synuclein NOUN fnp-9165 33 22 rostro rostro NOUN fnp-9165 33 23 - - PUNCT fnp-9165 33 24 caudally caudally ADV fnp-9165 33 25 , , PUNCT fnp-9165 33 26 and and CCONJ fnp-9165 33 27 at at ADP fnp-9165 33 28 each each DET fnp-9165 33 29 level level NOUN fnp-9165 33 30 dorso dorso NOUN fnp-9165 33 31 - - PUNCT fnp-9165 33 32 ventrally ventrally ADV fnp-9165 33 33 using use VERB fnp-9165 33 34 rexed rexe VERB fnp-9165 33 35 ’s ’s PART fnp-9165 33 36 laminae laminae NOUN fnp-9165 33 37 . . PUNCT fnp-9165 34 1 a a DET fnp-9165 34 2 semi semi ADJ fnp-9165 34 3 - - ADJ fnp-9165 34 4 quantitative quantitative ADJ fnp-9165 34 5 scale scale NOUN fnp-9165 34 6 was be AUX fnp-9165 34 7 used use VERB fnp-9165 34 8 . . PUNCT fnp-9165 35 1 lewy lewy PROPN fnp-9165 35 2 bodies body NOUN fnp-9165 35 3 , , PUNCT fnp-9165 35 4 lewy lewy PROPN fnp-9165 35 5 neurites neurite NOUN fnp-9165 35 6 and and CCONJ fnp-9165 35 7 granular granular ADJ fnp-9165 35 8 α α NOUN fnp-9165 35 9 - - PUNCT fnp-9165 35 10 synuclein synuclein NOUN fnp-9165 35 11 in in ADP fnp-9165 35 12 35 35 NUM fnp-9165 35 13 spinal spinal NOUN fnp-9165 35 14 cords cord NOUN fnp-9165 35 15 from from ADP fnp-9165 35 16 a a DET fnp-9165 35 17 sequential sequential ADJ fnp-9165 35 18 series series NOUN fnp-9165 35 19 of of ADP fnp-9165 35 20 patients patient NOUN fnp-9165 35 21 deceased decease VERB fnp-9165 35 22 from from ADP fnp-9165 35 23 2016 2016 NUM fnp-9165 35 24 to to ADP fnp-9165 35 25 2021 2021 NUM fnp-9165 35 26 showed show VERB fnp-9165 35 27 no no DET fnp-9165 35 28 caudo caudo NOUN fnp-9165 35 29 - - PUNCT fnp-9165 35 30 rostral rostral ADJ fnp-9165 35 31 gradient gradient NOUN fnp-9165 35 32 along along ADP fnp-9165 35 33 the the DET fnp-9165 35 34 length length NOUN fnp-9165 35 35 of of ADP fnp-9165 35 36 the the DET fnp-9165 35 37 spinal spinal NOUN fnp-9165 35 38 cord cord NOUN fnp-9165 35 39 . . PUNCT fnp-9165 36 1 however however ADV fnp-9165 36 2 , , PUNCT fnp-9165 36 3 α α X fnp-9165 36 4 - - PUNCT fnp-9165 36 5 synucleinopathy synucleinopathy NOUN fnp-9165 36 6 was be AUX fnp-9165 36 7 highest high ADJ fnp-9165 36 8 in in ADP fnp-9165 36 9 the the DET fnp-9165 36 10 thoracic thoracic NOUN fnp-9165 36 11 cord cord NOUN fnp-9165 36 12 , , PUNCT fnp-9165 36 13 lowest low ADJ fnp-9165 36 14 in in ADP fnp-9165 36 15 the the DET fnp-9165 36 16 sacral sacral ADJ fnp-9165 36 17 cord cord NOUN fnp-9165 36 18 . . PUNCT fnp-9165 37 1 intermediate intermediate ADJ fnp-9165 37 2 autonomic autonomic ADJ fnp-9165 37 3 lamina lamina NOUN fnp-9165 37 4 vii vii PROPN fnp-9165 37 5 of of ADP fnp-9165 37 6 rexed rexe VERB fnp-9165 37 7 showed show VERB fnp-9165 37 8 the the DET fnp-9165 37 9 highest high ADJ fnp-9165 37 10 α α NOUN fnp-9165 37 11 - - PUNCT fnp-9165 37 12 synuclein synuclein NOUN fnp-9165 37 13 compared compare VERB fnp-9165 37 14 to to ADP fnp-9165 37 15 dorsal dorsal VERB fnp-9165 37 16 sensory sensory ADJ fnp-9165 37 17 laminae laminae PROPN fnp-9165 37 18 i i PROPN fnp-9165 37 19 – – PUNCT fnp-9165 37 20 iv iv INTJ fnp-9165 37 21 ( ( PUNCT fnp-9165 37 22 p p X fnp-9165 37 23     SPACE fnp-9165 37 24 = = NOUN fnp-9165 37 25     SPACE fnp-9165 37 26 0.02 0.02 NUM fnp-9165 37 27 ) ) PUNCT fnp-9165 37 28 and and CCONJ fnp-9165 37 29 to to ADP fnp-9165 37 30 ventral ventral ADJ fnp-9165 37 31 motor motor NOUN fnp-9165 37 32 laminae laminae PROPN fnp-9165 37 33 viii viii PROPN fnp-9165 37 34 – – PUNCT fnp-9165 37 35 ix ix PUNCT fnp-9165 37 36 ( ( PUNCT fnp-9165 37 37 p p X fnp-9165 37 38     SPACE fnp-9165 37 39 = = NOUN fnp-9165 37 40     SPACE fnp-9165 37 41 0.02 0.02 NUM fnp-9165 37 42 ) ) PUNCT fnp-9165 37 43 . . PUNCT fnp-9165 38 1 clinical clinical ADJ fnp-9165 38 2 stratification stratification NOUN fnp-9165 38 3 by by ADP fnp-9165 38 4 braak braak NOUN fnp-9165 38 5 stage stage NOUN fnp-9165 38 6 showed show VERB fnp-9165 38 7 only only ADV fnp-9165 38 8 that that SCONJ fnp-9165 38 9 the the DET fnp-9165 38 10 autopsy autopsy ADJ fnp-9165 38 11 cases case NOUN fnp-9165 38 12 with with ADP fnp-9165 38 13 later later ADV fnp-9165 38 14 , , PUNCT fnp-9165 38 15 more more ADV fnp-9165 38 16 severe severe ADJ fnp-9165 38 17 braak braak NOUN fnp-9165 38 18 staging staging NOUN fnp-9165 38 19 had have AUX fnp-9165 38 20 earlier early ADJ fnp-9165 38 21 onset onset VERB fnp-9165 38 22 and and CCONJ fnp-9165 38 23 longer long ADJ fnp-9165 38 24 disease disease NOUN fnp-9165 38 25 duration duration NOUN fnp-9165 38 26 . . PUNCT fnp-9165 39 1 our our PRON fnp-9165 39 2 results result NOUN fnp-9165 39 3 show show VERB fnp-9165 39 4 that that SCONJ fnp-9165 39 5 directionality directionality NOUN fnp-9165 39 6 of of ADP fnp-9165 39 7 spread spread NOUN fnp-9165 39 8 within within ADP fnp-9165 39 9 the the DET fnp-9165 39 10 spinal spinal ADJ fnp-9165 39 11 cord cord NOUN fnp-9165 39 12 of of ADP fnp-9165 39 13 pd pd PROPN fnp-9165 39 14 is be AUX fnp-9165 39 15 heterogeneous heterogeneous ADJ fnp-9165 39 16 and and CCONJ fnp-9165 39 17 does do AUX fnp-9165 39 18 not not PART fnp-9165 39 19 correlate correlate VERB fnp-9165 39 20 with with ADP fnp-9165 39 21 braak braak NOUN fnp-9165 39 22 staging staging NOUN fnp-9165 39 23 . . PUNCT fnp-9165 40 1 the the DET fnp-9165 40 2 results result NOUN fnp-9165 40 3 lend lend VERB fnp-9165 40 4 no no DET fnp-9165 40 5 support support NOUN fnp-9165 40 6 for for ADP fnp-9165 40 7 a a DET fnp-9165 40 8 gradient gradient NOUN fnp-9165 40 9 of of ADP fnp-9165 40 10 α α NOUN fnp-9165 40 11 - - PUNCT fnp-9165 40 12 synuclein synuclein NOUN fnp-9165 40 13 within within ADP fnp-9165 40 14 the the DET fnp-9165 40 15 spinal spinal NOUN fnp-9165 40 16 cord cord NOUN fnp-9165 40 17 , , PUNCT fnp-9165 40 18 neither neither CCONJ fnp-9165 40 19 along along ADP fnp-9165 40 20 the the DET fnp-9165 40 21 neuraxis neuraxis NOUN fnp-9165 40 22 nor nor CCONJ fnp-9165 40 23 dorso dorso NOUN fnp-9165 40 24 - - PUNCT fnp-9165 40 25 ventrally ventrally ADV fnp-9165 40 26 within within ADP fnp-9165 40 27 any any DET fnp-9165 40 28 spinal spinal ADJ fnp-9165 40 29 level level NOUN fnp-9165 40 30 , , PUNCT fnp-9165 40 31 while while SCONJ fnp-9165 40 32 confirming confirm VERB fnp-9165 40 33 the the DET fnp-9165 40 34 autonomic autonomic ADJ fnp-9165 40 35 - - PUNCT fnp-9165 40 36 predominant predominant ADJ fnp-9165 40 37 distribution distribution NOUN fnp-9165 40 38 of of ADP fnp-9165 40 39 α α NOUN fnp-9165 40 40 - - PUNCT fnp-9165 40 41 synuclein synuclein NOUN fnp-9165 40 42 seen see VERB fnp-9165 40 43 in in ADP fnp-9165 40 44 the the DET fnp-9165 40 45 pd pd PROPN fnp-9165 40 46 spinal spinal PROPN fnp-9165 40 47 cord cord NOUN fnp-9165 40 48 . . PUNCT fnp-9165 40 49     SPACE fnp-9165 41 1 abstract abstract ADJ fnp-9165 41 2 4 4 NUM fnp-9165 41 3 free free ADJ fnp-9165 41 4 neuropathol neuropathol NOUN fnp-9165 41 5 6:23:7 6:23:7 NUM fnp-9165 41 6 comparison comparison NOUN fnp-9165 41 7 of of ADP fnp-9165 41 8 co co NOUN fnp-9165 41 9 - - NOUN fnp-9165 41 10 pathologies pathology NOUN fnp-9165 41 11 in in ADP fnp-9165 41 12 cte cte PROPN fnp-9165 41 13 - - PUNCT fnp-9165 41 14 nc nc PROPN fnp-9165 41 15 and and CCONJ fnp-9165 41 16 ggt ggt PROPN fnp-9165 41 17 and and CCONJ fnp-9165 41 18 case case NOUN fnp-9165 41 19 report report NOUN fnp-9165 41 20 of of ADP fnp-9165 41 21 an an DET fnp-9165 41 22 ex ex NOUN fnp-9165 41 23 - - NOUN fnp-9165 41 24 football football NOUN fnp-9165 41 25 player player NOUN fnp-9165 41 26 shelley shelley PROPN fnp-9165 41 27 l. l. PROPN fnp-9165 41 28 forrest1,2 forrest1,2 PROPN fnp-9165 41 29 , , PUNCT fnp-9165 41 30 nusrat nusrat PROPN fnp-9165 41 31 sadia3 sadia3 PROPN fnp-9165 41 32 , , PUNCT fnp-9165 41 33 mozhgan mozhgan PROPN fnp-9165 41 34 khodadadi3 khodadadi3 PROPN fnp-9165 41 35 , , PUNCT fnp-9165 41 36 charles charles PROPN fnp-9165 41 37 tator3,4 tator3,4 PROPN fnp-9165 41 38 , , PUNCT fnp-9165 41 39 robin robin PROPN fnp-9165 41 40 green3,5 green3,5 PROPN fnp-9165 41 41 , , PUNCT fnp-9165 41 42 maria maria PROPN fnp-9165 41 43 carmela carmela PROPN fnp-9165 41 44 tartaglia3,6 tartaglia3,6 PROPN fnp-9165 41 45 , , PUNCT fnp-9165 41 46 gabor gabor PROPN fnp-9165 41 47 g. g. PROPN fnp-9165 41 48 kovacs1,2,7,8 kovacs1,2,7,8 PROPN fnp-9165 41 49 tanz tanz PROPN fnp-9165 41 50 centre centre NOUN fnp-9165 41 51 for for ADP fnp-9165 41 52 research research NOUN fnp-9165 41 53 in in ADP fnp-9165 41 54 neurodegenerative neurodegenerative ADJ fnp-9165 41 55 disease disease NOUN fnp-9165 41 56 , , PUNCT fnp-9165 41 57 university university PROPN fnp-9165 41 58 of of ADP fnp-9165 41 59 toronto toronto PROPN fnp-9165 41 60 , , PUNCT fnp-9165 41 61 toronto toronto PROPN fnp-9165 41 62 , , PUNCT fnp-9165 41 63 canada canada PROPN fnp-9165 41 64 laboratory laboratory PROPN fnp-9165 41 65 medicine medicine PROPN fnp-9165 41 66 program program PROPN fnp-9165 41 67 & & CCONJ fnp-9165 41 68 krembil krembil PROPN fnp-9165 41 69 brain brain PROPN fnp-9165 41 70 institute institute PROPN fnp-9165 41 71 , , PUNCT fnp-9165 41 72 university university NOUN fnp-9165 41 73 health health NOUN fnp-9165 41 74 network network NOUN fnp-9165 41 75 , , PUNCT fnp-9165 41 76 toronto toronto PROPN fnp-9165 41 77 , , PUNCT fnp-9165 41 78 canada canada PROPN fnp-9165 41 79 canadian canadian PROPN fnp-9165 41 80 concussion concussion PROPN fnp-9165 41 81 centre centre NOUN fnp-9165 41 82 , , PUNCT fnp-9165 41 83 krembil krembil PROPN fnp-9165 41 84 brain brain PROPN fnp-9165 41 85 institute institute PROPN fnp-9165 41 86 , , PUNCT fnp-9165 41 87 university university NOUN fnp-9165 41 88 health health NOUN fnp-9165 41 89 network network NOUN fnp-9165 41 90 , , PUNCT fnp-9165 41 91 and and CCONJ fnp-9165 41 92 university university PROPN fnp-9165 41 93 of of ADP fnp-9165 41 94 toronto toronto PROPN fnp-9165 41 95 , , PUNCT fnp-9165 41 96 toronto toronto PROPN fnp-9165 41 97 , , PUNCT fnp-9165 41 98 canada canada PROPN fnp-9165 41 99 division division NOUN fnp-9165 41 100 of of ADP fnp-9165 41 101 neurosurgery neurosurgery NOUN fnp-9165 41 102 , , PUNCT fnp-9165 41 103 toronto toronto PROPN fnp-9165 41 104 western western ADJ fnp-9165 41 105 hospital hospital PROPN fnp-9165 41 106 , , PUNCT fnp-9165 41 107 university university PROPN fnp-9165 41 108 of of ADP fnp-9165 41 109 toronto toronto PROPN fnp-9165 41 110 , , PUNCT fnp-9165 41 111 toronto toronto PROPN fnp-9165 41 112 , , PUNCT fnp-9165 41 113 canada canada PROPN fnp-9165 41 114 kite kite PROPN fnp-9165 41 115 - - PUNCT fnp-9165 41 116 toronto toronto PROPN fnp-9165 41 117 rehab rehab NOUN fnp-9165 41 118 , , PUNCT fnp-9165 41 119 university university NOUN fnp-9165 41 120 centre centre NOUN fnp-9165 41 121 , , PUNCT fnp-9165 41 122 toronto toronto PROPN fnp-9165 41 123 , , PUNCT fnp-9165 41 124 canada canada PROPN fnp-9165 41 125 university university PROPN fnp-9165 41 126 health health PROPN fnp-9165 41 127 network network NOUN fnp-9165 41 128 memory memory NOUN fnp-9165 41 129 clinic clinic PROPN fnp-9165 41 130 & & CCONJ fnp-9165 41 131 krembil krembil PROPN fnp-9165 41 132 brain brain PROPN fnp-9165 41 133 institute institute PROPN fnp-9165 41 134 , , PUNCT fnp-9165 41 135 university university NOUN fnp-9165 41 136 health health NOUN fnp-9165 41 137 network network NOUN fnp-9165 41 138 , , PUNCT fnp-9165 41 139 toronto toronto PROPN fnp-9165 41 140 , , PUNCT fnp-9165 41 141 canada canada PROPN fnp-9165 41 142 edmond edmond PROPN fnp-9165 41 143 j. j. PROPN fnp-9165 41 144 safra safra PROPN fnp-9165 41 145 program program PROPN fnp-9165 41 146 in in ADP fnp-9165 41 147 parkinson parkinson NOUN fnp-9165 41 148 's 's PART fnp-9165 41 149 disease disease NOUN fnp-9165 41 150 , , PUNCT fnp-9165 41 151 rossy rossy PROPN fnp-9165 41 152 program program PROPN fnp-9165 41 153 for for ADP fnp-9165 41 154 psp psp NOUN fnp-9165 41 155 research research NOUN fnp-9165 41 156 and and CCONJ fnp-9165 41 157 the the DET fnp-9165 41 158 morton morton PROPN fnp-9165 41 159 and and CCONJ fnp-9165 41 160 gloria gloria PROPN fnp-9165 41 161 shulman shulman PROPN fnp-9165 41 162 movement movement PROPN fnp-9165 41 163 disorders disorder NOUN fnp-9165 41 164 clinic clinic PROPN fnp-9165 41 165 , , PUNCT fnp-9165 41 166 toronto toronto PROPN fnp-9165 41 167 western western PROPN fnp-9165 41 168 hospital hospital PROPN fnp-9165 41 169 , , PUNCT fnp-9165 41 170 toronto toronto PROPN fnp-9165 41 171 , , PUNCT fnp-9165 41 172 canada canada PROPN fnp-9165 41 173 department department PROPN fnp-9165 41 174 of of ADP fnp-9165 41 175 laboratory laboratory NOUN fnp-9165 41 176 medicine medicine NOUN fnp-9165 41 177 and and CCONJ fnp-9165 41 178 pathobiology pathobiology NOUN fnp-9165 41 179 and and CCONJ fnp-9165 41 180 department department NOUN fnp-9165 41 181 of of ADP fnp-9165 41 182 medicine medicine NOUN fnp-9165 41 183 , , PUNCT fnp-9165 41 184 university university PROPN fnp-9165 41 185 of of ADP fnp-9165 41 186 toronto toronto PROPN fnp-9165 41 187 , , PUNCT fnp-9165 41 188 toronto toronto PROPN fnp-9165 41 189 , , PUNCT fnp-9165 41 190 canada canada PROPN fnp-9165 41 191 to to PART fnp-9165 41 192 compare compare VERB fnp-9165 41 193 literature literature NOUN fnp-9165 41 194 observations observation NOUN fnp-9165 41 195 on on ADP fnp-9165 41 196 the the DET fnp-9165 41 197 frequency frequency NOUN fnp-9165 41 198 and and CCONJ fnp-9165 41 199 type type NOUN fnp-9165 41 200 of of ADP fnp-9165 41 201 co co NOUN fnp-9165 41 202 - - NOUN fnp-9165 41 203 pathologies pathology NOUN fnp-9165 41 204 associated associate VERB fnp-9165 41 205 with with ADP fnp-9165 41 206 chronic chronic ADJ fnp-9165 41 207 traumatic traumatic ADJ fnp-9165 41 208 encephalopathy encephalopathy ADJ fnp-9165 41 209 - - PUNCT fnp-9165 41 210 neuropathological neuropathological ADJ fnp-9165 41 211 change change NOUN fnp-9165 41 212 ( ( PUNCT fnp-9165 41 213 cte cte PROPN fnp-9165 41 214 - - PUNCT fnp-9165 41 215 nc nc PROPN fnp-9165 41 216 ) ) PUNCT fnp-9165 41 217 and and CCONJ fnp-9165 41 218 globular globular ADJ fnp-9165 41 219 glial glial ADJ fnp-9165 41 220 tauopathy tauopathy NOUN fnp-9165 41 221 ( ( PUNCT fnp-9165 41 222 ggt ggt NOUN fnp-9165 41 223 ) ) PUNCT fnp-9165 41 224 . . PUNCT fnp-9165 42 1 to to PART fnp-9165 42 2 report report VERB fnp-9165 42 3 an an DET fnp-9165 42 4 ex ex NOUN fnp-9165 42 5 - - NOUN fnp-9165 42 6 football football NOUN fnp-9165 42 7 player player NOUN fnp-9165 42 8 with with ADP fnp-9165 42 9 primary primary ADJ fnp-9165 42 10 progressive progressive ADJ fnp-9165 42 11 aphasia aphasia NOUN fnp-9165 42 12 , , PUNCT fnp-9165 42 13 and and CCONJ fnp-9165 42 14 an an DET fnp-9165 42 15 unprecedented unprecedented ADJ fnp-9165 42 16 combination combination NOUN fnp-9165 42 17 of of ADP fnp-9165 42 18 degenerative degenerative ADJ fnp-9165 42 19 pathologies pathology NOUN fnp-9165 42 20 , , PUNCT fnp-9165 42 21 including include VERB fnp-9165 42 22 cte cte PROPN fnp-9165 42 23 - - PUNCT fnp-9165 42 24 nc nc PROPN fnp-9165 42 25 . . PROPN fnp-9165 42 26 mixed mixed ADJ fnp-9165 42 27 neurodegenerative neurodegenerative ADJ fnp-9165 42 28 pathologies pathology NOUN fnp-9165 42 29 are be AUX fnp-9165 42 30 common common ADJ fnp-9165 42 31 but but CCONJ fnp-9165 42 32 can can AUX fnp-9165 42 33 be be AUX fnp-9165 42 34 overlooked overlook VERB fnp-9165 42 35 when when SCONJ fnp-9165 42 36 there there PRON fnp-9165 42 37 is be VERB fnp-9165 42 38 a a DET fnp-9165 42 39 more more ADV fnp-9165 42 40 obvious obvious ADJ fnp-9165 42 41 pathology pathology NOUN fnp-9165 42 42 . . PUNCT fnp-9165 43 1 literature literature PROPN fnp-9165 43 2 review review NOUN fnp-9165 43 3 and and CCONJ fnp-9165 43 4 summary summary NOUN fnp-9165 43 5 of of ADP fnp-9165 43 6 our our PRON fnp-9165 43 7 observations observation NOUN fnp-9165 43 8 in in ADP fnp-9165 43 9 cte cte PROPN fnp-9165 43 10 and and CCONJ fnp-9165 43 11 ggt ggt NOUN fnp-9165 43 12 cases case NOUN fnp-9165 43 13 . . PUNCT fnp-9165 44 1 an an DET fnp-9165 44 2 86 86 NUM fnp-9165 44 3 - - PUNCT fnp-9165 44 4 year year NOUN fnp-9165 44 5 - - PUNCT fnp-9165 44 6 old old ADJ fnp-9165 44 7 male male ADJ fnp-9165 44 8 former former ADJ fnp-9165 44 9 canadian canadian ADJ fnp-9165 44 10 football football NOUN fnp-9165 44 11 player player NOUN fnp-9165 44 12 was be AUX fnp-9165 44 13 longitudinally longitudinally ADV fnp-9165 44 14 followed follow VERB fnp-9165 44 15 in in ADP fnp-9165 44 16 the the DET fnp-9165 44 17 cognitive cognitive ADJ fnp-9165 44 18 neurology neurology NOUN fnp-9165 44 19 clinic clinic NOUN fnp-9165 44 20 at at ADP fnp-9165 44 21 toronto toronto PROPN fnp-9165 44 22 western western PROPN fnp-9165 44 23 hospital hospital NOUN fnp-9165 44 24 and and CCONJ fnp-9165 44 25 underwent undergo VERB fnp-9165 44 26 clinical clinical ADJ fnp-9165 44 27 assessments assessment NOUN fnp-9165 44 28 and and CCONJ fnp-9165 44 29 mri mri NOUN fnp-9165 44 30 scans scan NOUN fnp-9165 44 31 throughout throughout ADP fnp-9165 44 32 the the DET fnp-9165 44 33 disease disease NOUN fnp-9165 44 34 course course NOUN fnp-9165 44 35 . . PUNCT fnp-9165 45 1 paraffin paraffin NOUN fnp-9165 45 2 - - PUNCT fnp-9165 45 3 embedded embed VERB fnp-9165 45 4 sections section NOUN fnp-9165 45 5 from from ADP fnp-9165 45 6 all all DET fnp-9165 45 7 brain brain NOUN fnp-9165 45 8 regions region NOUN fnp-9165 45 9 available available ADJ fnp-9165 45 10 were be AUX fnp-9165 45 11 immunostained immunostaine VERB fnp-9165 45 12 with with ADP fnp-9165 45 13 histological histological ADJ fnp-9165 45 14 and and CCONJ fnp-9165 45 15 immunohistochemical immunohistochemical ADJ fnp-9165 45 16 stains stain NOUN fnp-9165 45 17 . . PUNCT fnp-9165 46 1 mixed mixed ADJ fnp-9165 46 2 pathologies pathology NOUN fnp-9165 46 3 are be AUX fnp-9165 46 4 frequently frequently ADV fnp-9165 46 5 associated associate VERB fnp-9165 46 6 with with ADP fnp-9165 46 7 cte cte PROPN fnp-9165 46 8 - - PUNCT fnp-9165 46 9 nc nc PROPN fnp-9165 46 10 associated associated PROPN fnp-9165 46 11 also also ADV fnp-9165 46 12 with with ADP fnp-9165 46 13 ageing age VERB fnp-9165 46 14 . . PUNCT fnp-9165 47 1 in in ADP fnp-9165 47 2 ggt ggt PROPN fnp-9165 47 3 the the DET fnp-9165 47 4 frequency frequency NOUN fnp-9165 47 5 is be AUX fnp-9165 47 6 lower low ADJ fnp-9165 47 7 but but CCONJ fnp-9165 47 8 unusual unusual ADJ fnp-9165 47 9 co co NOUN fnp-9165 47 10 - - NOUN fnp-9165 47 11 pathology pathology ADJ fnp-9165 47 12 constellations constellation NOUN fnp-9165 47 13 ( ( PUNCT fnp-9165 47 14 e.g. e.g. ADV fnp-9165 47 15 tdp-43 tdp-43 NOUN fnp-9165 47 16 ) ) PUNCT fnp-9165 47 17 may may AUX fnp-9165 47 18 occur occur VERB fnp-9165 47 19 . . PUNCT fnp-9165 48 1 in in ADP fnp-9165 48 2 the the DET fnp-9165 48 3 case case NOUN fnp-9165 48 4 presented present VERB fnp-9165 48 5 , , PUNCT fnp-9165 48 6 multiple multiple ADJ fnp-9165 48 7 and and CCONJ fnp-9165 48 8 rare rare ADJ fnp-9165 48 9 constellations constellation NOUN fnp-9165 48 10 of of ADP fnp-9165 48 11 degenerative degenerative ADJ fnp-9165 48 12 pathologies pathology NOUN fnp-9165 48 13 observed observe VERB fnp-9165 48 14 : : PUNCT fnp-9165 48 15 1 1 NUM fnp-9165 48 16 ) ) PUNCT fnp-9165 48 17 cte cte PROPN fnp-9165 48 18 - - PUNCT fnp-9165 48 19 nc nc PROPN fnp-9165 48 20 ( ( PUNCT fnp-9165 48 21 high high ADJ fnp-9165 48 22 level level NOUN fnp-9165 48 23 ) ) PUNCT fnp-9165 48 24 ; ; PUNCT fnp-9165 48 25 2 2 X fnp-9165 48 26 ) ) PUNCT fnp-9165 48 27 high high ADJ fnp-9165 48 28 level level NOUN fnp-9165 48 29 of of ADP fnp-9165 48 30 adnc adnc NOUN fnp-9165 48 31 ) ) PUNCT fnp-9165 48 32 ; ; PUNCT fnp-9165 48 33 3 3 X fnp-9165 48 34 ) ) PUNCT fnp-9165 48 35 lewy lewy ADJ fnp-9165 48 36 body body NOUN fnp-9165 48 37 disease disease NOUN fnp-9165 48 38 ( ( PUNCT fnp-9165 48 39 braak braak NOUN fnp-9165 48 40 stage stage NOUN fnp-9165 48 41 4 4 NUM fnp-9165 48 42 or or CCONJ fnp-9165 48 43 limbic limbic ADJ fnp-9165 48 44 type type NOUN fnp-9165 48 45 ) ) PUNCT fnp-9165 48 46 ; ; PUNCT fnp-9165 48 47 4 4 X fnp-9165 48 48 ) ) PUNCT fnp-9165 48 49 cerebral cerebral ADJ fnp-9165 48 50 amyloid amyloid NOUN fnp-9165 48 51 angiopathy angiopathy NOUN fnp-9165 48 52 ; ; PUNCT fnp-9165 48 53 5 5 X fnp-9165 48 54 ) ) PUNCT fnp-9165 48 55 argyrophilic argyrophilic ADJ fnp-9165 48 56 grain grain NOUN fnp-9165 48 57 disease disease NOUN fnp-9165 48 58 ; ; PUNCT fnp-9165 48 59 6 6 NUM fnp-9165 48 60 ) ) PUNCT fnp-9165 48 61 globular globular ADJ fnp-9165 48 62 glial glial ADJ fnp-9165 48 63 tauopathy tauopathy NOUN fnp-9165 48 64 type type NOUN fnp-9165 48 65 ii ii PROPN fnp-9165 48 66 ( ( PUNCT fnp-9165 48 67 corticospinal corticospinal ADJ fnp-9165 48 68 tract tract NOUN fnp-9165 48 69 involvement involvement NOUN fnp-9165 48 70 ) ) PUNCT fnp-9165 48 71 with with ADP fnp-9165 48 72 selective selective ADJ fnp-9165 48 73 and and CCONJ fnp-9165 48 74 asymmetric asymmetric ADJ fnp-9165 48 75 involvement involvement NOUN fnp-9165 48 76 of of ADP fnp-9165 48 77 the the DET fnp-9165 48 78 corticospinal corticospinal ADJ fnp-9165 48 79 tract tract NOUN fnp-9165 48 80 ; ; PUNCT fnp-9165 48 81 and and CCONJ fnp-9165 48 82 7 7 X fnp-9165 48 83 ) ) PUNCT fnp-9165 48 84 neuronal neuronal ADJ fnp-9165 48 85 intranuclear intranuclear NOUN fnp-9165 48 86 hyaline hyaline NOUN fnp-9165 48 87 inclusion inclusion NOUN fnp-9165 48 88 body body NOUN fnp-9165 48 89 disease disease NOUN fnp-9165 48 90 . . PUNCT fnp-9165 49 1 this this DET fnp-9165 49 2 study study NOUN fnp-9165 49 3 highlights highlight VERB fnp-9165 49 4 the the DET fnp-9165 49 5 spectrum spectrum NOUN fnp-9165 49 6 of of ADP fnp-9165 49 7 proteinopathies proteinopathie NOUN fnp-9165 49 8 that that PRON fnp-9165 49 9 can can AUX fnp-9165 49 10 be be AUX fnp-9165 49 11 associated associate VERB fnp-9165 49 12 with with ADP fnp-9165 49 13 multiple multiple ADJ fnp-9165 49 14 concussions concussion NOUN fnp-9165 49 15 and and CCONJ fnp-9165 49 16 demonstrates demonstrate VERB fnp-9165 49 17 that that PRON fnp-9165 49 18 unusual unusual ADJ fnp-9165 49 19 constellations constellation NOUN fnp-9165 49 20 of of ADP fnp-9165 49 21 rare rare ADJ fnp-9165 49 22 neurodegenerative neurodegenerative ADJ fnp-9165 49 23 diseases disease NOUN fnp-9165 49 24 beyond beyond ADP fnp-9165 49 25 adnc adnc ADJ fnp-9165 49 26 and and CCONJ fnp-9165 49 27 lewy lewy PROPN fnp-9165 49 28 body body NOUN fnp-9165 49 29 pathology pathology NOUN fnp-9165 49 30 can can AUX fnp-9165 49 31 be be AUX fnp-9165 49 32 observed observe VERB fnp-9165 49 33 as as ADP fnp-9165 49 34 co co NOUN fnp-9165 49 35 - - NOUN fnp-9165 49 36 pathologies pathology NOUN fnp-9165 49 37 in in ADP fnp-9165 49 38 the the DET fnp-9165 49 39 same same ADJ fnp-9165 49 40 individuals individual NOUN fnp-9165 49 41 . . PUNCT fnp-9165 49 42     SPACE fnp-9165 50 1 abstract abstract ADJ fnp-9165 50 2 5 5 NUM fnp-9165 50 3 free free ADJ fnp-9165 50 4 neuropathol neuropathol NOUN fnp-9165 50 5 6:23:8 6:23:8 NUM fnp-9165 50 6 does do AUX fnp-9165 50 7 the the DET fnp-9165 50 8 hla hla PROPN fnp-9165 50 9 locus locus NOUN fnp-9165 50 10 have have VERB fnp-9165 50 11 relevance relevance NOUN fnp-9165 50 12 in in ADP fnp-9165 50 13 progressing progress VERB fnp-9165 50 14 supranuclear supranuclear ADJ fnp-9165 50 15 palsy palsy ADJ fnp-9165 50 16 ? ? PUNCT fnp-9165 51 1 forrest forrest PROPN fnp-9165 51 2 sl1–3 sl1–3 PROPN fnp-9165 51 3 , , PUNCT fnp-9165 51 4 zaheer zaheer PROPN fnp-9165 51 5 ss3,4 ss3,4 PROPN fnp-9165 51 6 , , PUNCT fnp-9165 51 7 kim kim PROPN fnp-9165 51 8 a1 a1 PROPN fnp-9165 51 9 , , PUNCT fnp-9165 51 10 tanaka tanaka PROPN fnp-9165 51 11 h1 h1 PROPN fnp-9165 51 12 , , PUNCT fnp-9165 51 13 chasiotis chasiotis PROPN fnp-9165 51 14 h1 h1 NOUN fnp-9165 51 15 , , PUNCT fnp-9165 51 16 li li PROPN fnp-9165 51 17 j1 j1 PROPN fnp-9165 51 18 , , PUNCT fnp-9165 51 19 dasari dasari NOUN fnp-9165 51 20 s1 s1 PROPN fnp-9165 51 21 , , PUNCT fnp-9165 51 22 kalyaanamoorthy kalyaanamoorthy ADJ fnp-9165 51 23 s1 s1 NOUN fnp-9165 51 24 , , PUNCT fnp-9165 51 25 fox fox PROPN fnp-9165 51 26 sh3,4,7 sh3,4,7 PROPN fnp-9165 51 27 , , PUNCT fnp-9165 51 28 wang wang PROPN fnp-9165 51 29 j8,9 j8,9 PROPN fnp-9165 51 30 , , PUNCT fnp-9165 51 31 rogaeva rogaeva NOUN fnp-9165 51 32 e1 e1 PROPN fnp-9165 51 33 , , PUNCT fnp-9165 51 34 fox fox PROPN fnp-9165 51 35 s3,7 s3,7 PROPN fnp-9165 51 36 , , PUNCT fnp-9165 51 37 tartaglia tartaglia NOUN fnp-9165 51 38 mc1–3,7 mc1–3,7 NOUN fnp-9165 51 39 , , PUNCT fnp-9165 51 40 lang lang PROPN fnp-9165 51 41 ae1,3,4,7 ae1,3,4,7 PROPN fnp-9165 51 42 , , PUNCT fnp-9165 51 43 kovacs kovacs PROPN fnp-9165 51 44 gg1–7 gg1–7 PROPN fnp-9165 51 45 tanz tanz PROPN fnp-9165 51 46 centre centre VERB fnp-9165 51 47 for for ADP fnp-9165 51 48 research research NOUN fnp-9165 51 49 in in ADP fnp-9165 51 50 neurodegenerative neurodegenerative ADJ fnp-9165 51 51 diseases disease NOUN fnp-9165 51 52 , , PUNCT fnp-9165 51 53 university university NOUN fnp-9165 51 54 of of ADP fnp-9165 51 55 toronto toronto PROPN fnp-9165 51 56 , , PUNCT fnp-9165 51 57 toronto toronto PROPN fnp-9165 51 58 , , PUNCT fnp-9165 51 59 canada canada PROPN fnp-9165 51 60 krembil krembil PROPN fnp-9165 51 61 brain brain PROPN fnp-9165 51 62 institute institute PROPN fnp-9165 51 63 , , PUNCT fnp-9165 51 64 university university NOUN fnp-9165 51 65 health health NOUN fnp-9165 51 66 network network NOUN fnp-9165 51 67 , , PUNCT fnp-9165 51 68 toronto toronto PROPN fnp-9165 51 69 , , PUNCT fnp-9165 51 70 canada canada PROPN fnp-9165 51 71 rossy rossy PROPN fnp-9165 51 72 centre centre PROPN fnp-9165 51 73 for for ADP fnp-9165 51 74 psp psp NOUN fnp-9165 51 75 , , PUNCT fnp-9165 51 76 toronto toronto PROPN fnp-9165 51 77 western western PROPN fnp-9165 51 78 hospital hospital PROPN fnp-9165 51 79 , , PUNCT fnp-9165 51 80 toronto toronto PROPN fnp-9165 51 81 , , PUNCT fnp-9165 51 82 canada canada PROPN fnp-9165 51 83 edmond edmond PROPN fnp-9165 51 84 j. j. PROPN fnp-9165 51 85 safra safra PROPN fnp-9165 51 86 program program PROPN fnp-9165 51 87 in in ADP fnp-9165 51 88 parkinson parkinson NOUN fnp-9165 51 89 ’s ’s PART fnp-9165 51 90 disease disease NOUN fnp-9165 51 91 and and CCONJ fnp-9165 51 92 the the DET fnp-9165 51 93 morton morton PROPN fnp-9165 51 94 and and CCONJ fnp-9165 51 95 gloria gloria PROPN fnp-9165 51 96 shulman shulman PROPN fnp-9165 51 97 movement movement PROPN fnp-9165 51 98 disorders disorder NOUN fnp-9165 51 99 clinic clinic PROPN fnp-9165 51 100 , , PUNCT fnp-9165 51 101 toronto toronto PROPN fnp-9165 51 102 western western PROPN fnp-9165 51 103 hospital hospital PROPN fnp-9165 51 104 , , PUNCT fnp-9165 51 105 toronto toronto PROPN fnp-9165 51 106 , , PUNCT fnp-9165 51 107 canada canada PROPN fnp-9165 51 108 laboratory laboratory PROPN fnp-9165 51 109 medicine medicine PROPN fnp-9165 51 110 program program NOUN fnp-9165 51 111 , , PUNCT fnp-9165 51 112 university university NOUN fnp-9165 51 113 health health NOUN fnp-9165 51 114 network network NOUN fnp-9165 51 115 , , PUNCT fnp-9165 51 116 toronto toronto PROPN fnp-9165 51 117 , , PUNCT fnp-9165 51 118 canada canada PROPN fnp-9165 51 119 ; ; PUNCT fnp-9165 51 120 department department NOUN fnp-9165 51 121 of of ADP fnp-9165 51 122 chemistry chemistry NOUN fnp-9165 51 123 , , PUNCT fnp-9165 51 124 faculty faculty NOUN fnp-9165 51 125 of of ADP fnp-9165 51 126 science science NOUN fnp-9165 51 127 , , PUNCT fnp-9165 51 128 university university NOUN fnp-9165 51 129 of of ADP fnp-9165 51 130 waterloo waterloo PROPN fnp-9165 51 131 , , PUNCT fnp-9165 51 132 waterloo waterloo PROPN fnp-9165 51 133 , , PUNCT fnp-9165 51 134 canada canada PROPN fnp-9165 51 135 department department PROPN fnp-9165 51 136 of of ADP fnp-9165 51 137 chemistry chemistry NOUN fnp-9165 51 138 , , PUNCT fnp-9165 51 139 faculty faculty NOUN fnp-9165 51 140 of of ADP fnp-9165 51 141 science science NOUN fnp-9165 51 142 , , PUNCT fnp-9165 51 143 university university NOUN fnp-9165 51 144 of of ADP fnp-9165 51 145 waterloo waterloo PROPN fnp-9165 51 146 , , PUNCT fnp-9165 51 147 waterloo waterloo PROPN fnp-9165 51 148 , , PUNCT fnp-9165 51 149 canada canada PROPN fnp-9165 51 150 division division NOUN fnp-9165 51 151 of of ADP fnp-9165 51 152 neurology neurology NOUN fnp-9165 51 153 , , PUNCT fnp-9165 51 154 university university PROPN fnp-9165 51 155 of of ADP fnp-9165 51 156 toronto toronto PROPN fnp-9165 51 157 , , PUNCT fnp-9165 51 158 toronto toronto PROPN fnp-9165 51 159 , , PUNCT fnp-9165 51 160 canada canada PROPN fnp-9165 51 161 laboratory laboratory PROPN fnp-9165 51 162 medicine medicine PROPN fnp-9165 51 163 program program NOUN fnp-9165 51 164 , , PUNCT fnp-9165 51 165 university university NOUN fnp-9165 51 166 health health NOUN fnp-9165 51 167 network network NOUN fnp-9165 51 168 , , PUNCT fnp-9165 51 169 toronto toronto PROPN fnp-9165 51 170 , , PUNCT fnp-9165 51 171 canada canada PROPN fnp-9165 51 172 department department PROPN fnp-9165 51 173 of of ADP fnp-9165 51 174 laboratory laboratory NOUN fnp-9165 51 175 medicine medicine NOUN fnp-9165 51 176 and and CCONJ fnp-9165 51 177 pathobiology pathobiology NOUN fnp-9165 51 178 , , PUNCT fnp-9165 51 179 university university PROPN fnp-9165 51 180 of of ADP fnp-9165 51 181 toronto toronto PROPN fnp-9165 51 182 , , PUNCT fnp-9165 51 183 toronto toronto PROPN fnp-9165 51 184 , , PUNCT fnp-9165 51 185 canada canada PROPN fnp-9165 51 186 to to PART fnp-9165 51 187 investigate investigate VERB fnp-9165 51 188 the the DET fnp-9165 51 189 role role NOUN fnp-9165 51 190 of of ADP fnp-9165 51 191 human human ADJ fnp-9165 51 192 leukocyte leukocyte NOUN fnp-9165 51 193 antigen antigen NOUN fnp-9165 51 194 ( ( PUNCT fnp-9165 51 195 hla hla NOUN fnp-9165 51 196 ) ) PUNCT fnp-9165 51 197 haplotypes haplotype NOUN fnp-9165 51 198 in in ADP fnp-9165 51 199 progressive progressive ADJ fnp-9165 51 200 supranuclear supranuclear ADJ fnp-9165 51 201 palsy palsy ADJ fnp-9165 51 202 ( ( PUNCT fnp-9165 51 203 psp psp NOUN fnp-9165 51 204 ) ) PUNCT fnp-9165 51 205 and and CCONJ fnp-9165 51 206 evaluate evaluate VERB fnp-9165 51 207 its its PRON fnp-9165 51 208 relation relation NOUN fnp-9165 51 209 to to ADP fnp-9165 51 210 clinical clinical ADJ fnp-9165 51 211 and and CCONJ fnp-9165 51 212 pathological pathological ADJ fnp-9165 51 213 diversity diversity NOUN fnp-9165 51 214 . . PUNCT fnp-9165 52 1 psp psp NOUN fnp-9165 52 2 is be AUX fnp-9165 52 3 a a DET fnp-9165 52 4 neurodegenerative neurodegenerative ADJ fnp-9165 52 5 4 4 NUM fnp-9165 52 6 - - PUNCT fnp-9165 52 7 repeat repeat NOUN fnp-9165 52 8 tauopathy tauopathy NOUN fnp-9165 52 9 characterized characterize VERB fnp-9165 52 10 by by ADP fnp-9165 52 11 atypical atypical ADJ fnp-9165 52 12 parkinsonism parkinsonism NOUN fnp-9165 52 13 and and CCONJ fnp-9165 52 14 cognitive cognitive ADJ fnp-9165 52 15 - - PUNCT fnp-9165 52 16 behavioral behavioral ADJ fnp-9165 52 17 changes change NOUN fnp-9165 52 18 . . PUNCT fnp-9165 53 1 the the DET fnp-9165 53 2 hla hla PROPN fnp-9165 53 3 locus locus NOUN fnp-9165 53 4 has have AUX fnp-9165 53 5 not not PART fnp-9165 53 6 been be AUX fnp-9165 53 7 investigated investigate VERB fnp-9165 53 8 in in ADP fnp-9165 53 9 psp psp NOUN fnp-9165 53 10 , , PUNCT fnp-9165 53 11 but but CCONJ fnp-9165 53 12 has have AUX fnp-9165 53 13 been be AUX fnp-9165 53 14 implicated implicate VERB fnp-9165 53 15 in in ADP fnp-9165 53 16 autoimmune autoimmune ADJ fnp-9165 53 17 and and CCONJ fnp-9165 53 18 some some DET fnp-9165 53 19 neurological neurological ADJ fnp-9165 53 20 diseases disease NOUN fnp-9165 53 21 . . PUNCT fnp-9165 54 1 first first ADV fnp-9165 54 2 , , PUNCT fnp-9165 54 3 hla hla PROPN fnp-9165 54 4 haplotyping haplotyping NOUN fnp-9165 54 5 was be AUX fnp-9165 54 6 performed perform VERB fnp-9165 54 7 in in ADP fnp-9165 54 8 44 44 NUM fnp-9165 54 9 psp psp NOUN fnp-9165 54 10 cases case NOUN fnp-9165 54 11 compared compare VERB fnp-9165 54 12 to to ADP fnp-9165 54 13 a a DET fnp-9165 54 14 canadian canadian ADJ fnp-9165 54 15 deceased deceased ADJ fnp-9165 54 16 donor donor NOUN fnp-9165 54 17 pool pool NOUN fnp-9165 54 18 . . PUNCT fnp-9165 55 1 binding bind VERB fnp-9165 55 2 predictions prediction NOUN fnp-9165 55 3 were be AUX fnp-9165 55 4 used use VERB fnp-9165 55 5 to to PART fnp-9165 55 6 explore explore VERB fnp-9165 55 7 relation relation NOUN fnp-9165 55 8 of of ADP fnp-9165 55 9 hla hla NOUN fnp-9165 55 10 molecules molecule NOUN fnp-9165 55 11 and and CCONJ fnp-9165 55 12 tau tau PROPN fnp-9165 55 13 peptides peptide NOUN fnp-9165 55 14 . . PUNCT fnp-9165 56 1 second second ADJ fnp-9165 56 2 , , PUNCT fnp-9165 56 3 32 32 NUM fnp-9165 56 4 autopsy autopsy ADJ fnp-9165 56 5 - - PUNCT fnp-9165 56 6 confirmed confirm VERB fnp-9165 56 7 psp psp NOUN fnp-9165 56 8 cases case NOUN fnp-9165 56 9 were be AUX fnp-9165 56 10 grouped group VERB fnp-9165 56 11 by by ADP fnp-9165 56 12 hla hla PROPN fnp-9165 56 13 haplotypes haplotype NOUN fnp-9165 56 14 : : PUNCT fnp-9165 56 15 and and CCONJ fnp-9165 56 16 systematic systematic ADJ fnp-9165 56 17 analysis analysis NOUN fnp-9165 56 18 of of ADP fnp-9165 56 19 inflammatory inflammatory ADJ fnp-9165 56 20 cells cell NOUN fnp-9165 56 21 ( ( PUNCT fnp-9165 56 22 t t NOUN fnp-9165 56 23 and and CCONJ fnp-9165 56 24 b b PROPN fnp-9165 56 25 cells cell NOUN fnp-9165 56 26 , , PUNCT fnp-9165 56 27 microglia microglia NOUN fnp-9165 56 28 ) ) PUNCT fnp-9165 56 29 and and CCONJ fnp-9165 56 30 phosphorylated phosphorylate VERB fnp-9165 56 31 - - PUNCT fnp-9165 56 32 tau tau PROPN fnp-9165 56 33 was be AUX fnp-9165 56 34 performed perform VERB fnp-9165 56 35 . . PUNCT fnp-9165 57 1 statistical statistical ADJ fnp-9165 57 2 analysis analysis NOUN fnp-9165 57 3 considering consider VERB fnp-9165 57 4 confounding confound VERB fnp-9165 57 5 factors factor NOUN fnp-9165 57 6 and and CCONJ fnp-9165 57 7 machine machine NOUN fnp-9165 57 8 learning learning NOUN fnp-9165 57 9 was be AUX fnp-9165 57 10 used use VERB fnp-9165 57 11 evaluate evaluate VERB fnp-9165 57 12 the the DET fnp-9165 57 13 effect effect NOUN fnp-9165 57 14 of of ADP fnp-9165 57 15 hla hla PROPN fnp-9165 57 16 haplotypes haplotype NOUN fnp-9165 57 17 on on ADP fnp-9165 57 18 pathology pathology NOUN fnp-9165 57 19 variables variable NOUN fnp-9165 57 20 . . PUNCT fnp-9165 58 1 the the DET fnp-9165 58 2 dqb106:01 dqb106:01 ADJ fnp-9165 58 3 allele allele PROPN fnp-9165 58 4 showed show VERB fnp-9165 58 5 an an DET fnp-9165 58 6 odds odd NOUN fnp-9165 58 7 ratio ratio NOUN fnp-9165 58 8 of of ADP fnp-9165 58 9 2.94 2.94 NUM fnp-9165 58 10 ( ( PUNCT fnp-9165 58 11 95 95 NUM fnp-9165 58 12     SPACE fnp-9165 58 13 % % NOUN fnp-9165 58 14 ci ci NOUN fnp-9165 58 15 1.01–8.55 1.01–8.55 NUM fnp-9165 58 16 , , PUNCT fnp-9165 58 17 p p X fnp-9165 58 18     SPACE fnp-9165 58 19 = = NOUN fnp-9165 58 20     SPACE fnp-9165 58 21 0.047 0.047 NUM fnp-9165 58 22 ) ) PUNCT fnp-9165 58 23 , , PUNCT fnp-9165 58 24 and and CCONJ fnp-9165 58 25 the the DET fnp-9165 58 26 narcolepsy narcolepsy NOUN fnp-9165 58 27 - - PUNCT fnp-9165 58 28 associated associate VERB fnp-9165 58 29 haplotype haplotype NOUN fnp-9165 58 30 had have VERB fnp-9165 58 31 an an DET fnp-9165 58 32 odds odd NOUN fnp-9165 58 33 ratio ratio NOUN fnp-9165 58 34 of of ADP fnp-9165 58 35 2.59 2.59 NUM fnp-9165 58 36 ( ( PUNCT fnp-9165 58 37 95 95 NUM fnp-9165 58 38     SPACE fnp-9165 58 39 % % NOUN fnp-9165 58 40 ci ci NOUN fnp-9165 58 41 1.39–4.83 1.39–4.83 NUM fnp-9165 58 42 , , PUNCT fnp-9165 58 43 p p X fnp-9165 58 44     SPACE fnp-9165 58 45 = = NOUN fnp-9165 58 46     SPACE fnp-9165 58 47 0.0025 0.0025 NUM fnp-9165 58 48 ) ) PUNCT fnp-9165 58 49 . . PUNCT fnp-9165 59 1 hla hla PROPN fnp-9165 59 2 - - PUNCT fnp-9165 59 3 tau tau PROPN fnp-9165 59 4 peptide peptide ADJ fnp-9165 59 5 binding bind VERB fnp-9165 59 6 predictions prediction NOUN fnp-9165 59 7 confirmed confirm VERB fnp-9165 59 8 strong strong ADJ fnp-9165 59 9 tau tau PROPN fnp-9165 59 10 peptide peptide NOUN fnp-9165 59 11 binding bind VERB fnp-9165 59 12 to to ADP fnp-9165 59 13 alleles allele NOUN fnp-9165 59 14 dqa101:02 dqa101:02 NOUN fnp-9165 59 15 - - PUNCT fnp-9165 59 16 dqb106:02 dqb106:02 VERB fnp-9165 59 17 and and CCONJ fnp-9165 59 18 dqa101:03 dqa101:03 ADJ fnp-9165 59 19 - - PUNCT fnp-9165 59 20 dqb1 dqb1 ADJ fnp-9165 59 21 * * PUNCT fnp-9165 59 22 06:01 06:01 NUM fnp-9165 59 23 , , PUNCT fnp-9165 59 24 but but CCONJ fnp-9165 59 25 not not PART fnp-9165 59 26 to to ADP fnp-9165 59 27 the the DET fnp-9165 59 28 psp psp NOUN fnp-9165 59 29 - - PUNCT fnp-9165 59 30 protofilament protofilament NOUN fnp-9165 59 31 fold fold NOUN fnp-9165 59 32 . . PUNCT fnp-9165 60 1 we we PRON fnp-9165 60 2 observed observe VERB fnp-9165 60 3 differences difference NOUN fnp-9165 60 4 of of ADP fnp-9165 60 5 the the DET fnp-9165 60 6 constellations constellation NOUN fnp-9165 60 7 of of ADP fnp-9165 60 8 neuropathological neuropathological ADJ fnp-9165 60 9 variables variable NOUN fnp-9165 60 10 between between ADP fnp-9165 60 11 hla hla NOUN fnp-9165 60 12 haplotype haplotype NOUN fnp-9165 60 13 groups group NOUN fnp-9165 60 14 . . PUNCT fnp-9165 61 1 machine machine NOUN fnp-9165 61 2 learning learning PROPN fnp-9165 61 3 identified identify VERB fnp-9165 61 4 inflammatory inflammatory ADJ fnp-9165 61 5 markers marker NOUN fnp-9165 61 6 and and CCONJ fnp-9165 61 7 neuropathological neuropathological ADJ fnp-9165 61 8 ratios ratio NOUN fnp-9165 61 9 as as ADP fnp-9165 61 10 strong strong ADJ fnp-9165 61 11 predictors predictor NOUN fnp-9165 61 12 of of ADP fnp-9165 61 13 hla hla NOUN fnp-9165 61 14 haplotypes haplotype NOUN fnp-9165 61 15 ( ( PUNCT fnp-9165 61 16 clustering cluster VERB fnp-9165 61 17 accuracy accuracy NOUN fnp-9165 61 18 : : PUNCT fnp-9165 61 19 86.96 86.96 NUM fnp-9165 61 20     SPACE fnp-9165 61 21 % % NOUN fnp-9165 61 22 and and CCONJ fnp-9165 61 23 91.30 91.30 NUM fnp-9165 61 24     SPACE fnp-9165 61 25 % % NOUN fnp-9165 61 26 ) ) PUNCT fnp-9165 61 27 , , PUNCT fnp-9165 61 28 with with ADP fnp-9165 61 29 clinical clinical ADJ fnp-9165 61 30 symptom symptom NOUN fnp-9165 61 31 sequences sequence NOUN fnp-9165 61 32 and and CCONJ fnp-9165 61 33 neuropathological neuropathological ADJ fnp-9165 61 34 ratios ratio NOUN fnp-9165 61 35 achieving achieve VERB fnp-9165 61 36 prediction prediction NOUN fnp-9165 61 37 accuracies accuracy NOUN fnp-9165 61 38 of of ADP fnp-9165 61 39 80.00 80.00 NUM fnp-9165 61 40     SPACE fnp-9165 61 41 % % NOUN fnp-9165 61 42 and and CCONJ fnp-9165 61 43 71.43 71.43 NUM fnp-9165 61 44     SPACE fnp-9165 61 45 % % NOUN fnp-9165 61 46 , , PUNCT fnp-9165 61 47 respectively respectively ADV fnp-9165 61 48 . . PUNCT fnp-9165 62 1 these these DET fnp-9165 62 2 findings finding NOUN fnp-9165 62 3 highlight highlight VERB fnp-9165 62 4 hla hla PROPN fnp-9165 62 5 haplotype haplotype NOUN fnp-9165 62 6 - - PUNCT fnp-9165 62 7 dependent dependent ADJ fnp-9165 62 8 neuroinflammatory neuroinflammatory ADJ fnp-9165 62 9 and and CCONJ fnp-9165 62 10 pathological pathological ADJ fnp-9165 62 11 variations variation NOUN fnp-9165 62 12 in in ADP fnp-9165 62 13 psp psp NOUN fnp-9165 62 14 , , PUNCT fnp-9165 62 15 suggesting suggest VERB fnp-9165 62 16 potential potential NOUN fnp-9165 62 17 for for ADP fnp-9165 62 18 patient patient ADJ fnp-9165 62 19 stratification stratification NOUN fnp-9165 62 20 in in ADP fnp-9165 62 21 immune immune NOUN fnp-9165 62 22 - - PUNCT fnp-9165 62 23 modulating modulate VERB fnp-9165 62 24 therapy therapy NOUN fnp-9165 62 25 trials trial NOUN fnp-9165 62 26 . . PUNCT fnp-9165 62 27     SPACE fnp-9165 63 1 abstract abstract ADJ fnp-9165 63 2 6 6 NUM fnp-9165 63 3 free free ADJ fnp-9165 63 4 neuropathol neuropathol NOUN fnp-9165 63 5 6:23:9 6:23:9 NUM fnp-9165 63 6 cognitive cognitive ADJ fnp-9165 63 7 subtyping subtyping NOUN fnp-9165 63 8 in in ADP fnp-9165 63 9 schizophrenia schizophrenia NOUN fnp-9165 63 10 reveals reveal VERB fnp-9165 63 11 distinct distinct ADJ fnp-9165 63 12 clinicopathologic clinicopathologic ADJ fnp-9165 63 13 signatures signature NOUN fnp-9165 63 14 and and CCONJ fnp-9165 63 15 a a DET fnp-9165 63 16 vascular vascular NOUN fnp-9165 63 17 - - PUNCT fnp-9165 63 18 linked link VERB fnp-9165 63 19 cognitive cognitive ADJ fnp-9165 63 20 phenotype phenotype NOUN fnp-9165 63 21 naomi naomi NOUN fnp-9165 63 22 c. c. PROPN fnp-9165 63 23 futhey1–3 futhey1–3 PROPN fnp-9165 63 24 , , PUNCT fnp-9165 63 25 fidel fidel PROPN fnp-9165 63 26 vila vila PROPN fnp-9165 63 27 - - PUNCT fnp-9165 63 28 rodriguez4,5 rodriguez4,5 PROPN fnp-9165 63 29 , , PUNCT fnp-9165 63 30 shawn shawn PROPN fnp-9165 63 31 j. j. PROPN fnp-9165 63 32 stochmanski4 stochmanski4 PROPN fnp-9165 63 33 , , PUNCT fnp-9165 63 34 elizabeth elizabeth PROPN fnp-9165 63 35 gregory4 gregory4 PROPN fnp-9165 63 36 , , PUNCT fnp-9165 63 37 william william PROPN fnp-9165 63 38 honer4 honer4 PROPN fnp-9165 63 39 , , PUNCT fnp-9165 63 40 belen belen PROPN fnp-9165 63 41 arranz6,7 arranz6,7 PROPN fnp-9165 63 42 , , PUNCT fnp-9165 63 43 belen belen NOUN fnp-9165 63 44 ramos6–8 ramos6–8 PROPN fnp-9165 63 45 , , PUNCT fnp-9165 63 46 ana ana PROPN fnp-9165 63 47 escanilla6 escanilla6 PROPN fnp-9165 63 48 , , PUNCT fnp-9165 63 49 america america PROPN fnp-9165 63 50 vera vera PROPN fnp-9165 63 51 - - PUNCT fnp-9165 63 52 montecinos8,9 montecinos8,9 PROPN fnp-9165 63 53 , , PUNCT fnp-9165 63 54 mark mark NOUN fnp-9165 63 55 s. s. PROPN fnp-9165 63 56 cembrowski1,2,5,10 cembrowski1,2,5,10 PROPN fnp-9165 63 57 , , PUNCT fnp-9165 63 58 veronica veronica PROPN fnp-9165 63 59 hirsch hirsch PROPN fnp-9165 63 60 - - PUNCT fnp-9165 63 61 reinshagen3 reinshagen3 PROPN fnp-9165 63 62 djavad djavad NOUN fnp-9165 63 63 mowafaghian mowafaghian PROPN fnp-9165 63 64 centre centre PROPN fnp-9165 63 65 for for ADP fnp-9165 63 66 brain brain NOUN fnp-9165 63 67 health health NOUN fnp-9165 63 68 , , PUNCT fnp-9165 63 69 university university NOUN fnp-9165 63 70 of of ADP fnp-9165 63 71 british british PROPN fnp-9165 63 72 columbia columbia PROPN fnp-9165 63 73 , , PUNCT fnp-9165 63 74 vancouver vancouver PROPN fnp-9165 63 75 , , PUNCT fnp-9165 63 76 canada canada PROPN fnp-9165 63 77 department department PROPN fnp-9165 63 78 of of ADP fnp-9165 63 79 cellular cellular ADJ fnp-9165 63 80 ; ; PUNCT fnp-9165 63 81 physiological physiological ADJ fnp-9165 63 82 sciences science NOUN fnp-9165 63 83 , , PUNCT fnp-9165 63 84 faculty faculty NOUN fnp-9165 63 85 of of ADP fnp-9165 63 86 medicine medicine NOUN fnp-9165 63 87 , , PUNCT fnp-9165 63 88 university university NOUN fnp-9165 63 89 of of ADP fnp-9165 63 90 british british PROPN fnp-9165 63 91 columbia columbia PROPN fnp-9165 63 92 , , PUNCT fnp-9165 63 93 vancouver vancouver PROPN fnp-9165 63 94 , , PUNCT fnp-9165 63 95 canada canada PROPN fnp-9165 63 96 department department PROPN fnp-9165 63 97 of of ADP fnp-9165 63 98 pathology pathology PROPN fnp-9165 63 99 and and CCONJ fnp-9165 63 100 laboratory laboratory NOUN fnp-9165 63 101 medicine medicine NOUN fnp-9165 63 102 , , PUNCT fnp-9165 63 103 faculty faculty NOUN fnp-9165 63 104 of of ADP fnp-9165 63 105 medicine medicine NOUN fnp-9165 63 106 , , PUNCT fnp-9165 63 107 university university NOUN fnp-9165 63 108 of of ADP fnp-9165 63 109 british british PROPN fnp-9165 63 110 columbia columbia PROPN fnp-9165 63 111 , , PUNCT fnp-9165 63 112 vancouver vancouver PROPN fnp-9165 63 113 , , PUNCT fnp-9165 63 114 canada canada PROPN fnp-9165 63 115 department department PROPN fnp-9165 63 116 of of ADP fnp-9165 63 117 psychiatry psychiatry NOUN fnp-9165 63 118 , , PUNCT fnp-9165 63 119 university university NOUN fnp-9165 63 120 of of ADP fnp-9165 63 121 british british PROPN fnp-9165 63 122 columbia columbia PROPN fnp-9165 63 123 , , PUNCT fnp-9165 63 124 vancouver vancouver PROPN fnp-9165 63 125 , , PUNCT fnp-9165 63 126 canada canada PROPN fnp-9165 63 127 school school PROPN fnp-9165 63 128 of of ADP fnp-9165 63 129 biomedical biomedical ADJ fnp-9165 63 130 engineering engineering NOUN fnp-9165 63 131 , , PUNCT fnp-9165 63 132 university university NOUN fnp-9165 63 133 of of ADP fnp-9165 63 134 british british PROPN fnp-9165 63 135 columbia columbia PROPN fnp-9165 63 136 , , PUNCT fnp-9165 63 137 vancouver vancouver PROPN fnp-9165 63 138 , , PUNCT fnp-9165 63 139 canada canada PROPN fnp-9165 63 140 parc parc PROPN fnp-9165 63 141 sanitari sanitari PROPN fnp-9165 63 142 sant sant PROPN fnp-9165 63 143 joan joan PROPN fnp-9165 63 144 de de PROPN fnp-9165 63 145 déu déu PROPN fnp-9165 63 146 , , PUNCT fnp-9165 63 147 dr dr PROPN fnp-9165 63 148 . . PROPN fnp-9165 63 149 antoni antoni PROPN fnp-9165 63 150 pujadas pujadas PROPN fnp-9165 63 151 , , PUNCT fnp-9165 63 152 sant sant ADJ fnp-9165 63 153 boi boi NOUN fnp-9165 63 154 de de X fnp-9165 63 155 llobregat llobregat PROPN fnp-9165 63 156 , , PUNCT fnp-9165 63 157 spain spain PROPN fnp-9165 63 158 centro centro PROPN fnp-9165 63 159 de de PROPN fnp-9165 63 160 investigación investigación PROPN fnp-9165 63 161 biomédica biomédica PROPN fnp-9165 63 162 en en PROPN fnp-9165 63 163 red red PROPN fnp-9165 63 164 de de PROPN fnp-9165 63 165 salud salud PROPN fnp-9165 63 166 mental mental ADJ fnp-9165 63 167 , , PUNCT fnp-9165 63 168 cibersam cibersam PROPN fnp-9165 63 169 ( ( PUNCT fnp-9165 63 170 biomedical biomedical ADJ fnp-9165 63 171 network network NOUN fnp-9165 63 172 research research NOUN fnp-9165 63 173 center center NOUN fnp-9165 63 174 of of ADP fnp-9165 63 175 mental mental ADJ fnp-9165 63 176 health health NOUN fnp-9165 63 177 ) ) PUNCT fnp-9165 63 178 , , PUNCT fnp-9165 63 179 ministry ministry NOUN fnp-9165 63 180 of of ADP fnp-9165 63 181 economy economy NOUN fnp-9165 63 182 , , PUNCT fnp-9165 63 183 industry industry NOUN fnp-9165 63 184 and and CCONJ fnp-9165 63 185 competitiveness competitiveness NOUN fnp-9165 63 186 institute institute PROPN fnp-9165 63 187 of of ADP fnp-9165 63 188 health health PROPN fnp-9165 63 189 carlos carlos PROPN fnp-9165 63 190 iii iii PROPN fnp-9165 63 191 , , PUNCT fnp-9165 63 192 madrid madrid PROPN fnp-9165 63 193 , , PUNCT fnp-9165 63 194 spain spain PROPN fnp-9165 63 195 psiquiatria psiquiatria PROPN fnp-9165 63 196 molecular molecular PROPN fnp-9165 63 197 , , PUNCT fnp-9165 63 198 institut institut PROPN fnp-9165 63 199 de de PROPN fnp-9165 63 200 recerca recerca PROPN fnp-9165 63 201 sant sant PROPN fnp-9165 63 202 joan joan PROPN fnp-9165 63 203 de de PROPN fnp-9165 63 204 déu déu PROPN fnp-9165 63 205 , , PUNCT fnp-9165 63 206 esplugues esplugue NOUN fnp-9165 63 207 de de ADP fnp-9165 63 208 llobregat llobregat PROPN fnp-9165 63 209 , , PUNCT fnp-9165 63 210 spain spain PROPN fnp-9165 63 211 departamento departamento PROPN fnp-9165 63 212 de de PROPN fnp-9165 63 213 ciencias ciencias PROPN fnp-9165 63 214 biológicas biológicas PROPN fnp-9165 63 215 y y PROPN fnp-9165 63 216 químicas químicas PROPN fnp-9165 63 217 , , PUNCT fnp-9165 63 218 facultad facultad PROPN fnp-9165 63 219 de de PROPN fnp-9165 63 220 ciencias ciencias PROPN fnp-9165 63 221 , , PUNCT fnp-9165 63 222 universidad universidad PROPN fnp-9165 63 223 san san PROPN fnp-9165 63 224 sebastián sebastián PROPN fnp-9165 63 225 , , PUNCT fnp-9165 63 226 sede sede X fnp-9165 63 227 tres tres X fnp-9165 63 228 pascualas pascualas PROPN fnp-9165 63 229 lientur lientur PROPN fnp-9165 63 230 1457 1457 NUM fnp-9165 63 231 , , PUNCT fnp-9165 63 232 concepción concepción NOUN fnp-9165 63 233 , , PUNCT fnp-9165 63 234 chile chile PROPN fnp-9165 63 235 department department PROPN fnp-9165 63 236 of of ADP fnp-9165 63 237 mathematics mathematics PROPN fnp-9165 63 238 , , PUNCT fnp-9165 63 239 university university PROPN fnp-9165 63 240 of of ADP fnp-9165 63 241 british british PROPN fnp-9165 63 242 columbia columbia PROPN fnp-9165 63 243 , , PUNCT fnp-9165 63 244 vancouver vancouver PROPN fnp-9165 63 245 , , PUNCT fnp-9165 63 246 canada canada PROPN fnp-9165 63 247 cognitive cognitive ADJ fnp-9165 63 248 impairment impairment NOUN fnp-9165 63 249 is be AUX fnp-9165 63 250 a a DET fnp-9165 63 251 defining define VERB fnp-9165 63 252 feature feature NOUN fnp-9165 63 253 of of ADP fnp-9165 63 254 chronic chronic ADJ fnp-9165 63 255 schizophrenia schizophrenia NOUN fnp-9165 63 256 , , PUNCT fnp-9165 63 257 but but CCONJ fnp-9165 63 258 its its PRON fnp-9165 63 259 underlying underlying ADJ fnp-9165 63 260 neuropathology neuropathology NOUN fnp-9165 63 261 remains remain VERB fnp-9165 63 262 unclear unclear ADJ fnp-9165 63 263 and and CCONJ fnp-9165 63 264 treatment treatment NOUN fnp-9165 63 265 options option NOUN fnp-9165 63 266 are be AUX fnp-9165 63 267 scarce scarce ADJ fnp-9165 63 268 . . PUNCT fnp-9165 64 1 the the DET fnp-9165 64 2 contributions contribution NOUN fnp-9165 64 3 of of ADP fnp-9165 64 4 alzheimer alzheimer PROPN fnp-9165 64 5 ’s ’s PART fnp-9165 64 6 disease disease NOUN fnp-9165 64 7 ( ( PUNCT fnp-9165 64 8 ad ad NOUN fnp-9165 64 9 ) ) PUNCT fnp-9165 64 10 and and CCONJ fnp-9165 64 11 cerebrovascular cerebrovascular ADJ fnp-9165 64 12 disease disease NOUN fnp-9165 64 13 ( ( PUNCT fnp-9165 64 14 cvd cvd PROPN fnp-9165 64 15 ) ) PUNCT fnp-9165 64 16 pathology pathology NOUN fnp-9165 64 17 to to ADP fnp-9165 64 18 cognitive cognitive ADJ fnp-9165 64 19 decline decline NOUN fnp-9165 64 20 in in ADP fnp-9165 64 21 older old ADJ fnp-9165 64 22 patients patient NOUN fnp-9165 64 23 are be AUX fnp-9165 64 24 particularly particularly ADV fnp-9165 64 25 understudied understudied ADJ fnp-9165 64 26 . . PUNCT fnp-9165 65 1 this this DET fnp-9165 65 2 study study NOUN fnp-9165 65 3 examined examine VERB fnp-9165 65 4 the the DET fnp-9165 65 5 relationship relationship NOUN fnp-9165 65 6 between between ADP fnp-9165 65 7 postmortem postmortem NOUN fnp-9165 65 8 neuropathology neuropathology NOUN fnp-9165 65 9 and and CCONJ fnp-9165 65 10 neuropsychological neuropsychological ADJ fnp-9165 65 11 performance performance NOUN fnp-9165 65 12 in in ADP fnp-9165 65 13 55 55 NUM fnp-9165 65 14 patients patient NOUN fnp-9165 65 15 ( ( PUNCT fnp-9165 65 16 mean mean VERB fnp-9165 65 17 age age NOUN fnp-9165 65 18 78 78 NUM fnp-9165 65 19 ) ) PUNCT fnp-9165 65 20 , , PUNCT fnp-9165 65 21 representing represent VERB fnp-9165 65 22 , , PUNCT fnp-9165 65 23 to to ADP fnp-9165 65 24 our our PRON fnp-9165 65 25 knowledge knowledge NOUN fnp-9165 65 26 , , PUNCT fnp-9165 65 27 the the DET fnp-9165 65 28 most most ADV fnp-9165 65 29 detailed detailed ADJ fnp-9165 65 30 clinicopathologic clinicopathologic ADJ fnp-9165 65 31 investigation investigation NOUN fnp-9165 65 32 of of ADP fnp-9165 65 33 late late ADJ fnp-9165 65 34 - - PUNCT fnp-9165 65 35 life life NOUN fnp-9165 65 36 schizophrenia schizophrenia NOUN fnp-9165 65 37 to to ADP fnp-9165 65 38 date date NOUN fnp-9165 65 39 . . PUNCT fnp-9165 66 1 although although SCONJ fnp-9165 66 2 70 70 NUM fnp-9165 66 3     SPACE fnp-9165 66 4 % % NOUN fnp-9165 66 5 met meet VERB fnp-9165 66 6 criteria criterion NOUN fnp-9165 66 7 for for ADP fnp-9165 66 8 cognitive cognitive ADJ fnp-9165 66 9 impairment impairment NOUN fnp-9165 66 10 , , PUNCT fnp-9165 66 11 the the DET fnp-9165 66 12 prevalence prevalence NOUN fnp-9165 66 13 of of ADP fnp-9165 66 14 ad ad NOUN fnp-9165 66 15 pathology pathology NOUN fnp-9165 66 16 ( ( PUNCT fnp-9165 66 17 35.1 35.1 NUM fnp-9165 66 18     SPACE fnp-9165 66 19 % % NOUN fnp-9165 66 20 ) ) PUNCT fnp-9165 66 21 was be AUX fnp-9165 66 22 comparable comparable ADJ fnp-9165 66 23 to to ADP fnp-9165 66 24 that that PRON fnp-9165 66 25 reported report VERB fnp-9165 66 26 in in ADP fnp-9165 66 27 age age NOUN fnp-9165 66 28 - - PUNCT fnp-9165 66 29 matched match VERB fnp-9165 66 30 controls control NOUN fnp-9165 66 31 . . PUNCT fnp-9165 67 1 in in ADP fnp-9165 67 2 contrast contrast NOUN fnp-9165 67 3 , , PUNCT fnp-9165 67 4 cvd cvd PROPN fnp-9165 67 5 pathology pathology PROPN fnp-9165 67 6 was be AUX fnp-9165 67 7 more more ADV fnp-9165 67 8 frequent frequent ADJ fnp-9165 67 9 ( ( PUNCT fnp-9165 67 10 84.2 84.2 NUM fnp-9165 67 11     SPACE fnp-9165 67 12 % % NOUN fnp-9165 67 13 ) ) PUNCT fnp-9165 67 14 and and CCONJ fnp-9165 67 15 significantly significantly ADV fnp-9165 67 16 associated associate VERB fnp-9165 67 17 with with ADP fnp-9165 67 18 lower low ADJ fnp-9165 67 19 mini mini ADJ fnp-9165 67 20 - - ADJ fnp-9165 67 21 mental mental ADJ fnp-9165 67 22 state state NOUN fnp-9165 67 23 examination examination NOUN fnp-9165 67 24 ( ( PUNCT fnp-9165 67 25 mmse mmse ADJ fnp-9165 67 26 ) ) PUNCT fnp-9165 67 27 scores score NOUN fnp-9165 67 28 ( ( PUNCT fnp-9165 67 29 b b NOUN fnp-9165 67 30 = = PUNCT fnp-9165 67 31 – – PUNCT fnp-9165 67 32 6.40 6.40 NUM fnp-9165 67 33 , , PUNCT fnp-9165 67 34 p p X fnp-9165 67 35         SPACE fnp-9165 67 36 abstract abstract ADJ fnp-9165 67 37 7 7 NUM fnp-9165 67 38 free free ADJ fnp-9165 67 39 neuropathol neuropathol NOUN fnp-9165 67 40 6:23:11 6:23:11 NUM fnp-9165 67 41 mapping map VERB fnp-9165 67 42 the the DET fnp-9165 67 43 digital digital ADJ fnp-9165 67 44 divide divide NOUN fnp-9165 67 45 : : PUNCT fnp-9165 67 46 underrepresentation underrepresentation NOUN fnp-9165 67 47 of of ADP fnp-9165 67 48 neuropathology neuropathology NOUN fnp-9165 67 49 in in ADP fnp-9165 67 50 large large ADJ fnp-9165 67 51 language language NOUN fnp-9165 67 52 model model NOUN fnp-9165 67 53 - - PUNCT fnp-9165 67 54 driven drive VERB fnp-9165 67 55 diagnostic diagnostic ADJ fnp-9165 67 56 literature literature NOUN fnp-9165 67 57 vladimir vladimir PROPN fnp-9165 67 58 ( ( PUNCT fnp-9165 67 59 vova vova PROPN fnp-9165 67 60 ) ) PUNCT fnp-9165 67 61 r. r. PROPN fnp-9165 67 62 auer1 auer1 PROPN fnp-9165 67 63 , , PUNCT fnp-9165 67 64 pramath pramath PROPN fnp-9165 67 65 kakodkar1 kakodkar1 PROPN fnp-9165 67 66 , , PUNCT fnp-9165 67 67 daniel daniel PROPN fnp-9165 67 68 markewich1 markewich1 PROPN fnp-9165 67 69 , , PUNCT fnp-9165 67 70 nooshin nooshin PROPN fnp-9165 67 71 shekari2 shekari2 PROPN fnp-9165 67 72 , , PUNCT fnp-9165 67 73 bryan bryan PROPN fnp-9165 67 74 johnston1 johnston1 PROPN fnp-9165 67 75 , , PUNCT fnp-9165 67 76 viktor viktor NOUN fnp-9165 67 77 zherebitskiy1 zherebitskiy1 NOUN fnp-9165 67 78 , , PUNCT fnp-9165 67 79 roland roland PROPN fnp-9165 67 80 n. n. PROPN fnp-9165 67 81 auer1 auer1 PROPN fnp-9165 67 82 , , PUNCT fnp-9165 67 83 jay jay PROPN fnp-9165 67 84 kalra1 kalra1 PROPN fnp-9165 67 85 department department PROPN fnp-9165 67 86 pathology pathology PROPN fnp-9165 67 87 and and CCONJ fnp-9165 67 88 lab lab NOUN fnp-9165 67 89 medicine medicine NOUN fnp-9165 67 90 , , PUNCT fnp-9165 67 91 university university PROPN fnp-9165 67 92 of of ADP fnp-9165 67 93 saskatchewan saskatchewan PROPN fnp-9165 67 94 , , PUNCT fnp-9165 67 95 saskatoon saskatoon PROPN fnp-9165 67 96 , , PUNCT fnp-9165 67 97 canada canada PROPN fnp-9165 67 98 department department PROPN fnp-9165 67 99 of of ADP fnp-9165 67 100 anatomy anatomy PROPN fnp-9165 67 101 , , PUNCT fnp-9165 67 102 physiology physiology NOUN fnp-9165 67 103 , , PUNCT fnp-9165 67 104 pharmacology pharmacology NOUN fnp-9165 67 105 , , PUNCT fnp-9165 67 106 university university PROPN fnp-9165 67 107 of of ADP fnp-9165 67 108 saskatchewan saskatchewan PROPN fnp-9165 67 109 , , PUNCT fnp-9165 67 110 saskatoon saskatoon PROPN fnp-9165 67 111 , , PUNCT fnp-9165 67 112 canada canada PROPN fnp-9165 67 113 an an DET fnp-9165 67 114 llm llm PROPN fnp-9165 67 115 ( ( PUNCT fnp-9165 67 116 large large ADJ fnp-9165 67 117 language language NOUN fnp-9165 67 118 model model NOUN fnp-9165 67 119 ) ) PUNCT fnp-9165 67 120 is be AUX fnp-9165 67 121 an an DET fnp-9165 67 122 artificial artificial ADJ fnp-9165 67 123 intelligence intelligence NOUN fnp-9165 67 124 ( ( PUNCT fnp-9165 67 125 ai ai NOUN fnp-9165 67 126 ) ) PUNCT fnp-9165 67 127 trained train VERB fnp-9165 67 128 on on ADP fnp-9165 67 129 massive massive ADJ fnp-9165 67 130 amounts amount NOUN fnp-9165 67 131 of of ADP fnp-9165 67 132 text text NOUN fnp-9165 67 133 to to PART fnp-9165 67 134 predict predict VERB fnp-9165 67 135 the the DET fnp-9165 67 136 next next ADJ fnp-9165 67 137 word word NOUN fnp-9165 67 138 , , PUNCT fnp-9165 67 139 letting let VERB fnp-9165 67 140 it it PRON fnp-9165 67 141 generate generate VERB fnp-9165 67 142 and and CCONJ fnp-9165 67 143 work work VERB fnp-9165 67 144 with with ADP fnp-9165 67 145 human‑like human‑like NOUN fnp-9165 67 146 language language NOUN fnp-9165 67 147 . . PUNCT fnp-9165 68 1 the the DET fnp-9165 68 2 objective objective NOUN fnp-9165 68 3 of of ADP fnp-9165 68 4 this this DET fnp-9165 68 5 study study NOUN fnp-9165 68 6 is be AUX fnp-9165 68 7 to to PART fnp-9165 68 8 assess assess VERB fnp-9165 68 9 the the DET fnp-9165 68 10 representation representation NOUN fnp-9165 68 11 and and CCONJ fnp-9165 68 12 diagnostic diagnostic ADJ fnp-9165 68 13 utility utility NOUN fnp-9165 68 14 of of ADP fnp-9165 68 15 llms llm NOUN fnp-9165 68 16 in in ADP fnp-9165 68 17 clinical clinical ADJ fnp-9165 68 18 neuroscience neuroscience NOUN fnp-9165 68 19 with with ADP fnp-9165 68 20 a a DET fnp-9165 68 21 focus focus NOUN fnp-9165 68 22 on on ADP fnp-9165 68 23 neuropathology neuropathology NOUN fnp-9165 68 24 compared compare VERB fnp-9165 68 25 to to ADP fnp-9165 68 26 other other ADJ fnp-9165 68 27 subspecialties subspecialtie NOUN fnp-9165 68 28 . . PUNCT fnp-9165 69 1 we we PRON fnp-9165 69 2 performed perform VERB fnp-9165 69 3 a a DET fnp-9165 69 4 prisma prisma NOUN fnp-9165 69 5 ( ( PUNCT fnp-9165 69 6 preferred prefer VERB fnp-9165 69 7 reporting reporting NOUN fnp-9165 69 8 items item NOUN fnp-9165 69 9 for for ADP fnp-9165 69 10 systematic systematic ADJ fnp-9165 69 11 reviews review NOUN fnp-9165 69 12 and and CCONJ fnp-9165 69 13 meta meta ADJ fnp-9165 69 14 - - PUNCT fnp-9165 69 15 analyses analysis NOUN fnp-9165 69 16 ) ) PUNCT fnp-9165 69 17 compliant compliant ADJ fnp-9165 69 18 review review NOUN fnp-9165 69 19 of of ADP fnp-9165 69 20 539 539 NUM fnp-9165 69 21 articles article NOUN fnp-9165 69 22 ( ( PUNCT fnp-9165 69 23 chatgpt chatgpt NOUN fnp-9165 69 24 ( ( PUNCT fnp-9165 69 25 n n CCONJ fnp-9165 69 26     SPACE fnp-9165 69 27 = = NOUN fnp-9165 69 28     SPACE fnp-9165 69 29 508 508 NUM fnp-9165 69 30 ) ) PUNCT fnp-9165 69 31 , , PUNCT fnp-9165 69 32 google google PROPN fnp-9165 69 33 gemini gemini PROPN fnp-9165 69 34 ( ( PUNCT fnp-9165 69 35 n n CCONJ fnp-9165 69 36     SPACE fnp-9165 69 37 = = NOUN fnp-9165 69 38     SPACE fnp-9165 69 39 14 14 NUM fnp-9165 69 40 ) ) PUNCT fnp-9165 69 41 , , PUNCT fnp-9165 69 42 perplexity perplexity NOUN fnp-9165 69 43 ( ( PUNCT fnp-9165 69 44 n n CCONJ fnp-9165 69 45     SPACE fnp-9165 69 46 = = NOUN fnp-9165 69 47     SPACE fnp-9165 69 48 10 10 NUM fnp-9165 69 49 ) ) PUNCT fnp-9165 69 50 , , PUNCT fnp-9165 69 51 deepseek deepseek ADJ fnp-9165 69 52 ( ( PUNCT fnp-9165 69 53 n n CCONJ fnp-9165 69 54     SPACE fnp-9165 69 55 = = NOUN fnp-9165 69 56     SPACE fnp-9165 69 57 7 7 NUM fnp-9165 69 58 ) ) PUNCT fnp-9165 69 59 ) ) PUNCT fnp-9165 69 60 spanning span VERB fnp-9165 69 61 the the DET fnp-9165 69 62 years year NOUN fnp-9165 69 63 2022–2025 2022–2025 NUM fnp-9165 69 64 . . PUNCT fnp-9165 70 1 studies study NOUN fnp-9165 70 2 were be AUX fnp-9165 70 3 categorized categorize VERB fnp-9165 70 4 by by ADP fnp-9165 70 5 subspecialty subspecialty NOUN fnp-9165 70 6 , , PUNCT fnp-9165 70 7 input input NOUN fnp-9165 70 8 data data NOUN fnp-9165 70 9 type type NOUN fnp-9165 70 10 ( ( PUNCT fnp-9165 70 11 admission admission NOUN fnp-9165 70 12 note note NOUN fnp-9165 70 13 , , PUNCT fnp-9165 70 14 radiological radiological ADJ fnp-9165 70 15 imaging imaging NOUN fnp-9165 70 16 , , PUNCT fnp-9165 70 17 radiology radiology NOUN fnp-9165 70 18 report report NOUN fnp-9165 70 19 , , PUNCT fnp-9165 70 20 pathology pathology NOUN fnp-9165 70 21 images image NOUN fnp-9165 70 22 , , PUNCT fnp-9165 70 23 pathology pathology NOUN fnp-9165 70 24 report report NOUN fnp-9165 70 25 ) ) PUNCT fnp-9165 70 26 , , PUNCT fnp-9165 70 27 and and CCONJ fnp-9165 70 28 assessed assess VERB fnp-9165 70 29 llm llm PROPN fnp-9165 70 30 outcomes outcome NOUN fnp-9165 70 31 ( ( PUNCT fnp-9165 70 32 diagnosis diagnosis NOUN fnp-9165 70 33 , , PUNCT fnp-9165 70 34 grading grading NOUN fnp-9165 70 35 , , PUNCT fnp-9165 70 36 prognosis prognosis NOUN fnp-9165 70 37 ) ) PUNCT fnp-9165 70 38 . . PUNCT fnp-9165 71 1 only only ADV fnp-9165 71 2 11.9 11.9 NUM fnp-9165 71 3     SPACE fnp-9165 71 4 % % NOUN fnp-9165 71 5 ( ( PUNCT fnp-9165 71 6 n n CCONJ fnp-9165 71 7     SPACE fnp-9165 71 8 = = NOUN fnp-9165 71 9     SPACE fnp-9165 71 10 64 64 NUM fnp-9165 71 11 ) ) PUNCT fnp-9165 71 12 of of ADP fnp-9165 71 13 included include VERB fnp-9165 71 14 studies study NOUN fnp-9165 71 15 focused focus VERB fnp-9165 71 16 on on ADP fnp-9165 71 17 clinical clinical ADJ fnp-9165 71 18 neuroscience neuroscience NOUN fnp-9165 71 19 , , PUNCT fnp-9165 71 20 and and CCONJ fnp-9165 71 21 just just ADV fnp-9165 71 22 3 3 NUM fnp-9165 71 23 were be AUX fnp-9165 71 24 dedicated dedicate VERB fnp-9165 71 25 to to ADP fnp-9165 71 26 neuropathology neuropathology NOUN fnp-9165 71 27 . . PUNCT fnp-9165 72 1 these these DET fnp-9165 72 2 studies study NOUN fnp-9165 72 3 targeted target VERB fnp-9165 72 4 gliomas glioma NOUN fnp-9165 72 5 and and CCONJ fnp-9165 72 6 neurodegenerative neurodegenerative ADJ fnp-9165 72 7 disorders disorder NOUN fnp-9165 72 8 . . PUNCT fnp-9165 73 1 the the DET fnp-9165 73 2 other other ADJ fnp-9165 73 3 specialty specialty NOUN fnp-9165 73 4 that that PRON fnp-9165 73 5 had have VERB fnp-9165 73 6 the the DET fnp-9165 73 7 highest high ADJ fnp-9165 73 8 llm llm NOUN fnp-9165 73 9 utilization utilization NOUN fnp-9165 73 10 was be AUX fnp-9165 73 11 radiology radiology NOUN fnp-9165 73 12 ( ( PUNCT fnp-9165 73 13 11.3 11.3 NUM fnp-9165 73 14     SPACE fnp-9165 73 15 % % NOUN fnp-9165 73 16 , , PUNCT fnp-9165 73 17 n n CCONJ fnp-9165 73 18     SPACE fnp-9165 73 19 = = NOUN fnp-9165 73 20     SPACE fnp-9165 73 21 61 61 NUM fnp-9165 73 22 ) ) PUNCT fnp-9165 73 23 . . PUNCT fnp-9165 74 1 neuropathology neuropathology NOUN fnp-9165 74 2 - - PUNCT fnp-9165 74 3 dedicated dedicate VERB fnp-9165 74 4 studies study NOUN fnp-9165 74 5 lagged lag VERB fnp-9165 74 6 in in ADP fnp-9165 74 7 sample sample NOUN fnp-9165 74 8 size size NOUN fnp-9165 74 9 , , PUNCT fnp-9165 74 10 external external ADJ fnp-9165 74 11 validation validation NOUN fnp-9165 74 12 , , PUNCT fnp-9165 74 13 and and CCONJ fnp-9165 74 14 model model NOUN fnp-9165 74 15 robustness robustness NOUN fnp-9165 74 16 , , PUNCT fnp-9165 74 17 especially especially ADV fnp-9165 74 18 compared compare VERB fnp-9165 74 19 with with ADP fnp-9165 74 20 other other ADJ fnp-9165 74 21 pathology pathology NOUN fnp-9165 74 22 ( ( PUNCT fnp-9165 74 23 n n CCONJ fnp-9165 74 24     SPACE fnp-9165 74 25 = = NOUN fnp-9165 74 26     SPACE fnp-9165 74 27 37 37 NUM fnp-9165 74 28 ) ) PUNCT fnp-9165 74 29 subspecialties subspecialtie NOUN fnp-9165 74 30 such such ADJ fnp-9165 74 31 as as ADP fnp-9165 74 32 head head NOUN fnp-9165 74 33 and and CCONJ fnp-9165 74 34 neck neck NOUN fnp-9165 74 35 ( ( PUNCT fnp-9165 74 36 n n CCONJ fnp-9165 74 37     SPACE fnp-9165 74 38 = = NOUN fnp-9165 74 39     SPACE fnp-9165 74 40 9 9 NUM fnp-9165 74 41 ) ) PUNCT fnp-9165 74 42 , , PUNCT fnp-9165 74 43 general general ADJ fnp-9165 74 44 surgical surgical ADJ fnp-9165 74 45 pathology pathology NOUN fnp-9165 74 46 ( ( PUNCT fnp-9165 74 47 n n CCONJ fnp-9165 74 48     SPACE fnp-9165 74 49 = = NOUN fnp-9165 74 50     SPACE fnp-9165 74 51 7 7 NUM fnp-9165 74 52 ) ) PUNCT fnp-9165 74 53 , , PUNCT fnp-9165 74 54 gastrointestinal gastrointestinal NOUN fnp-9165 74 55 ( ( PUNCT fnp-9165 74 56 n n CCONJ fnp-9165 74 57     SPACE fnp-9165 74 58 = = NOUN fnp-9165 74 59     SPACE fnp-9165 74 60 5 5 NUM fnp-9165 74 61 ) ) PUNCT fnp-9165 74 62 and and CCONJ fnp-9165 74 63 gynecological gynecological ADJ fnp-9165 74 64 pathology pathology NOUN fnp-9165 74 65 ( ( PUNCT fnp-9165 74 66 n n CCONJ fnp-9165 74 67     SPACE fnp-9165 74 68 = = NOUN fnp-9165 74 69     SPACE fnp-9165 74 70 4 4 NUM fnp-9165 74 71 ) ) PUNCT fnp-9165 74 72 . . PUNCT fnp-9165 75 1 neuropathology neuropathology NOUN fnp-9165 75 2 remains remain VERB fnp-9165 75 3 significantly significantly ADV fnp-9165 75 4 underrepresented underrepresented ADJ fnp-9165 75 5 in in ADP fnp-9165 75 6 the the DET fnp-9165 75 7 era era NOUN fnp-9165 75 8 of of ADP fnp-9165 75 9 diagnostic diagnostic ADJ fnp-9165 75 10 ai ai NOUN fnp-9165 75 11 . . PUNCT fnp-9165 76 1 given give VERB fnp-9165 76 2 the the DET fnp-9165 76 3 distinctive distinctive ADJ fnp-9165 76 4 morphologic morphologic ADJ fnp-9165 76 5 and and CCONJ fnp-9165 76 6 molecular molecular ADJ fnp-9165 76 7 complexity complexity NOUN fnp-9165 76 8 of of ADP fnp-9165 76 9 cns cns PROPN fnp-9165 76 10 ( ( PUNCT fnp-9165 76 11 central central ADJ fnp-9165 76 12 nervous nervous ADJ fnp-9165 76 13 system system NOUN fnp-9165 76 14 ) ) PUNCT fnp-9165 76 15 lesions lesion NOUN fnp-9165 76 16 , , PUNCT fnp-9165 76 17 there there PRON fnp-9165 76 18 is be VERB fnp-9165 76 19 an an DET fnp-9165 76 20 urgent urgent ADJ fnp-9165 76 21 need need NOUN fnp-9165 76 22 for for ADP fnp-9165 76 23 dedicated dedicated ADJ fnp-9165 76 24 model model NOUN fnp-9165 76 25 development development NOUN fnp-9165 76 26 and and CCONJ fnp-9165 76 27 rigorous rigorous ADJ fnp-9165 76 28 validation validation NOUN fnp-9165 76 29 tailored tailor VERB fnp-9165 76 30 to to ADP fnp-9165 76 31 neuropathology neuropathology NOUN fnp-9165 76 32 . . PUNCT fnp-9165 76 33     SPACE fnp-9165 77 1 abstract abstract ADJ fnp-9165 77 2 8 8 NUM fnp-9165 77 3 free free ADJ fnp-9165 77 4 neuropathol neuropathol NOUN fnp-9165 77 5 6:23:12 6:23:12 NUM fnp-9165 77 6 onsight onsight NOUN fnp-9165 77 7 : : PUNCT fnp-9165 77 8 a a DET fnp-9165 77 9 real real ADJ fnp-9165 77 10 - - PUNCT fnp-9165 77 11 time time NOUN fnp-9165 77 12 computational computational ADJ fnp-9165 77 13 pathology pathology NOUN fnp-9165 77 14 companion companion NOUN fnp-9165 77 15 for for ADP fnp-9165 77 16 histopathology histopathology NOUN fnp-9165 77 17 kevin kevin PROPN fnp-9165 77 18 faust1 faust1 PROPN fnp-9165 77 19 , , PUNCT fnp-9165 77 20 jinzhen jinzhen NOUN fnp-9165 77 21 hu1 hu1 PROPN fnp-9165 77 22 , , PUNCT fnp-9165 77 23 parsa parsa NOUN fnp-9165 77 24 babaei babaei PROPN fnp-9165 77 25 zadeh1 zadeh1 PROPN fnp-9165 77 26 , , PUNCT fnp-9165 77 27 adrienn adrienn ADP fnp-9165 77 28 bourkas1 bourkas1 PROPN fnp-9165 77 29 , , PUNCT fnp-9165 77 30 dimitrios dimitrio NOUN fnp-9165 77 31 oreopoulos1 oreopoulos1 PROPN fnp-9165 77 32 , , PUNCT fnp-9165 77 33 phedias phedia NOUN fnp-9165 77 34 diamandis1,2 diamandis1,2 PROPN fnp-9165 77 35 princess princess NOUN fnp-9165 77 36 margaret margaret PROPN fnp-9165 77 37 cancer cancer PROPN fnp-9165 77 38 centre centre PROPN fnp-9165 77 39 , , PUNCT fnp-9165 77 40 toronto toronto PROPN fnp-9165 77 41 , , PUNCT fnp-9165 77 42 canada canada PROPN fnp-9165 77 43 department department PROPN fnp-9165 77 44 of of ADP fnp-9165 77 45 laboratory laboratory NOUN fnp-9165 77 46 medicine medicine NOUN fnp-9165 77 47 and and CCONJ fnp-9165 77 48 pathobiology pathobiology NOUN fnp-9165 77 49 , , PUNCT fnp-9165 77 50 university university PROPN fnp-9165 77 51 of of ADP fnp-9165 77 52 toronto toronto PROPN fnp-9165 77 53 , , PUNCT fnp-9165 77 54 toronto toronto PROPN fnp-9165 77 55 , , PUNCT fnp-9165 77 56 canada canada PROPN fnp-9165 77 57 precise precise ADJ fnp-9165 77 58 microscopic microscopic ADJ fnp-9165 77 59 examination examination NOUN fnp-9165 77 60 of of ADP fnp-9165 77 61 surgical surgical ADJ fnp-9165 77 62 tissue tissue NOUN fnp-9165 77 63 sections section NOUN fnp-9165 77 64 is be AUX fnp-9165 77 65 a a DET fnp-9165 77 66 specialized specialized ADJ fnp-9165 77 67 skill skill NOUN fnp-9165 77 68 critical critical ADJ fnp-9165 77 69 for for ADP fnp-9165 77 70 diagnosis diagnosis NOUN fnp-9165 77 71 and and CCONJ fnp-9165 77 72 clinical clinical ADJ fnp-9165 77 73 care care NOUN fnp-9165 77 74 . . PUNCT fnp-9165 78 1 while while SCONJ fnp-9165 78 2 artificial artificial ADJ fnp-9165 78 3 intelligence intelligence NOUN fnp-9165 78 4 ( ( PUNCT fnp-9165 78 5 ai ai NOUN fnp-9165 78 6 ) ) PUNCT fnp-9165 78 7 shows show VERB fnp-9165 78 8 promise promise NOUN fnp-9165 78 9 for for ADP fnp-9165 78 10 histological histological ADJ fnp-9165 78 11 analysis analysis NOUN fnp-9165 78 12 , , PUNCT fnp-9165 78 13 differences difference NOUN fnp-9165 78 14 in in ADP fnp-9165 78 15 slide slide NOUN fnp-9165 78 16 digitization digitization NOUN fnp-9165 78 17 and and CCONJ fnp-9165 78 18 proprietary proprietary ADJ fnp-9165 78 19 software software NOUN fnp-9165 78 20 limit limit VERB fnp-9165 78 21 real real ADJ fnp-9165 78 22 - - PUNCT fnp-9165 78 23 world world NOUN fnp-9165 78 24 deployment deployment NOUN fnp-9165 78 25 . . PUNCT fnp-9165 79 1 we we PRON fnp-9165 79 2 present present VERB fnp-9165 79 3 onsight onsight NOUN fnp-9165 79 4 , , PUNCT fnp-9165 79 5 a a DET fnp-9165 79 6 platform platform NOUN fnp-9165 79 7 - - PUNCT fnp-9165 79 8 agnostic agnostic ADJ fnp-9165 79 9 computer computer NOUN fnp-9165 79 10 vision vision NOUN fnp-9165 79 11 software software NOUN fnp-9165 79 12 providing provide VERB fnp-9165 79 13 real real ADJ fnp-9165 79 14 - - PUNCT fnp-9165 79 15 time time NOUN fnp-9165 79 16 ai ai VERB fnp-9165 79 17 inferences inference NOUN fnp-9165 79 18 to to ADP fnp-9165 79 19 pathologists pathologist NOUN fnp-9165 79 20 during during ADP fnp-9165 79 21 digital digital ADJ fnp-9165 79 22 slide slide NOUN fnp-9165 79 23 review review NOUN fnp-9165 79 24 . . PUNCT fnp-9165 80 1 onsight onsight PROPN fnp-9165 80 2 is be AUX fnp-9165 80 3 freely freely ADV fnp-9165 80 4 accessible accessible ADJ fnp-9165 80 5 as as ADP fnp-9165 80 6 a a DET fnp-9165 80 7 single single ADJ fnp-9165 80 8 executable executable ADJ fnp-9165 80 9 file file NOUN fnp-9165 80 10 , , PUNCT fnp-9165 80 11 runs run VERB fnp-9165 80 12 locally locally ADV fnp-9165 80 13 on on ADP fnp-9165 80 14 consumer consumer NOUN fnp-9165 80 15 - - PUNCT fnp-9165 80 16 grade grade NOUN fnp-9165 80 17 computers computer NOUN fnp-9165 80 18 , , PUNCT fnp-9165 80 19 and and CCONJ fnp-9165 80 20 requires require VERB fnp-9165 80 21 no no DET fnp-9165 80 22 complex complex ADJ fnp-9165 80 23 integration integration NOUN fnp-9165 80 24 , , PUNCT fnp-9165 80 25 enabling enable VERB fnp-9165 80 26 cost cost NOUN fnp-9165 80 27 - - PUNCT fnp-9165 80 28 effective effective ADJ fnp-9165 80 29 and and CCONJ fnp-9165 80 30 safe safe ADJ fnp-9165 80 31 use use NOUN fnp-9165 80 32 in in ADP fnp-9165 80 33 research research NOUN fnp-9165 80 34 and and CCONJ fnp-9165 80 35 clinical clinical ADJ fnp-9165 80 36 workflows workflow NOUN fnp-9165 80 37 . . PUNCT fnp-9165 81 1 onsight onsight PROPN fnp-9165 81 2 was be AUX fnp-9165 81 3 benchmarked benchmarke VERB fnp-9165 81 4 on on ADP fnp-9165 81 5 classification classification NOUN fnp-9165 81 6 , , PUNCT fnp-9165 81 7 mitosis mitosis NOUN fnp-9165 81 8 detection detection NOUN fnp-9165 81 9 , , PUNCT fnp-9165 81 10 and and CCONJ fnp-9165 81 11 immunohistochemical immunohistochemical ADJ fnp-9165 81 12 quantification quantification NOUN fnp-9165 81 13 . . PUNCT fnp-9165 82 1 for for ADP fnp-9165 82 2 tumor tumor NOUN fnp-9165 82 3 classification classification NOUN fnp-9165 82 4 ( ( PUNCT fnp-9165 82 5 glioma glioma NOUN fnp-9165 82 6 , , PUNCT fnp-9165 82 7 meningioma meningioma NOUN fnp-9165 82 8 , , PUNCT fnp-9165 82 9 schwannoma schwannoma ADJ fnp-9165 82 10 , , PUNCT fnp-9165 82 11 epithelial epithelial ADJ fnp-9165 82 12 metastasis metastasis NOUN fnp-9165 82 13 ) ) PUNCT fnp-9165 82 14 , , PUNCT fnp-9165 82 15 a a DET fnp-9165 82 16 vit vit NOUN fnp-9165 82 17 - - PUNCT fnp-9165 82 18 b/16 b/16 NOUN fnp-9165 82 19 pretrained pretraine VERB fnp-9165 82 20 on on ADP fnp-9165 82 21 the the DET fnp-9165 82 22 kaiko kaiko PROPN fnp-9165 82 23 foundation foundation NOUN fnp-9165 82 24 model model NOUN fnp-9165 82 25 was be AUX fnp-9165 82 26 fine fine ADV fnp-9165 82 27 - - PUNCT fnp-9165 82 28 tuned tune VERB fnp-9165 82 29 on on ADP fnp-9165 82 30 80,000 80,000 NUM fnp-9165 82 31 h&e h&e PROPN fnp-9165 82 32 tiles tile NOUN fnp-9165 82 33 from from ADP fnp-9165 82 34 uhn uhn PROPN fnp-9165 82 35 at at ADP fnp-9165 82 36 20×. 20×. PROPN fnp-9165 82 37 ki-67 ki-67 ADJ fnp-9165 82 38 nuclei nucleus NOUN fnp-9165 82 39 were be AUX fnp-9165 82 40 segmented segment VERB fnp-9165 82 41 with with ADP fnp-9165 82 42 a a DET fnp-9165 82 43 yolo yolo ADJ fnp-9165 82 44 model model NOUN fnp-9165 82 45 trained train VERB fnp-9165 82 46 on on ADP fnp-9165 82 47 qupath qupath NOUN fnp-9165 82 48 - - PUNCT fnp-9165 82 49 annotated annotate VERB fnp-9165 82 50 patches patch NOUN fnp-9165 82 51 from from ADP fnp-9165 82 52 10 10 NUM fnp-9165 82 53 cases case NOUN fnp-9165 82 54 . . PUNCT fnp-9165 83 1 mitotic mitotic ADJ fnp-9165 83 2 figures figure NOUN fnp-9165 83 3 were be AUX fnp-9165 83 4 detected detect VERB fnp-9165 83 5 with with ADP fnp-9165 83 6 a a DET fnp-9165 83 7 retinanet retinanet NOUN fnp-9165 83 8 fpn fpn NOUN fnp-9165 83 9 ( ( PUNCT fnp-9165 83 10 resnet-50 resnet-50 NOUN fnp-9165 83 11 backbone backbone NOUN fnp-9165 83 12 ) ) PUNCT fnp-9165 83 13 trained train VERB fnp-9165 83 14 on on ADP fnp-9165 83 15 midog++ midog++ PROPN fnp-9165 83 16 at at ADP fnp-9165 83 17 40×. 40×. PROPN fnp-9165 83 18 validation validation NOUN fnp-9165 83 19 used use VERB fnp-9165 83 20 tcga tcga PROPN fnp-9165 83 21 and and CCONJ fnp-9165 83 22 uhn uhn NOUN fnp-9165 83 23 cases case NOUN fnp-9165 83 24 . . PUNCT fnp-9165 84 1 tumor tumor NOUN fnp-9165 84 2 classification classification NOUN fnp-9165 84 3 accuracy accuracy NOUN fnp-9165 84 4 was be AUX fnp-9165 84 5 95 95 NUM fnp-9165 84 6     SPACE fnp-9165 84 7 % % NOUN fnp-9165 84 8 across across ADP fnp-9165 84 9 public public ADJ fnp-9165 84 10 and and CCONJ fnp-9165 84 11 institutional institutional ADJ fnp-9165 84 12 sets set NOUN fnp-9165 84 13 . . PUNCT fnp-9165 85 1 mitosis mitosis NOUN fnp-9165 85 2 detection detection NOUN fnp-9165 85 3 showed show VERB fnp-9165 85 4 high high ADJ fnp-9165 85 5 area area NOUN fnp-9165 85 6 under under ADP fnp-9165 85 7 the the DET fnp-9165 85 8 curve curve NOUN fnp-9165 85 9 and and CCONJ fnp-9165 85 10 agreement agreement NOUN fnp-9165 85 11 with with ADP fnp-9165 85 12 manual manual ADJ fnp-9165 85 13 review review NOUN fnp-9165 85 14 . . PUNCT fnp-9165 86 1 automated automate VERB fnp-9165 86 2 ki-67 ki-67 ADJ fnp-9165 86 3 indexing indexing NOUN fnp-9165 86 4 showed show VERB fnp-9165 86 5 closer close ADJ fnp-9165 86 6 agreement agreement NOUN fnp-9165 86 7 with with ADP fnp-9165 86 8 neuropathologist neuropathologist ADJ fnp-9165 86 9 counts count NOUN fnp-9165 86 10 than than ADP fnp-9165 86 11 qupath qupath NOUN fnp-9165 86 12 and and CCONJ fnp-9165 86 13 is be AUX fnp-9165 86 14 reported report VERB fnp-9165 86 15 as as ADP fnp-9165 86 16 a a DET fnp-9165 86 17 percentage percentage NOUN fnp-9165 86 18 . . PUNCT fnp-9165 87 1 median median ADJ fnp-9165 87 2 per per ADP fnp-9165 87 3 - - PUNCT fnp-9165 87 4 field field NOUN fnp-9165 87 5 latency latency NOUN fnp-9165 87 6 was be AUX fnp-9165 87 7 0.3 0.3 NUM fnp-9165 87 8     SPACE fnp-9165 87 9 s s PROPN fnp-9165 87 10 , , PUNCT fnp-9165 87 11 enabling enable VERB fnp-9165 87 12 real real ADJ fnp-9165 87 13 - - PUNCT fnp-9165 87 14 time time NOUN fnp-9165 87 15 use use NOUN fnp-9165 87 16 . . PUNCT fnp-9165 88 1 onsight onsight PROPN fnp-9165 88 2 provides provide VERB fnp-9165 88 3 accurate accurate ADJ fnp-9165 88 4 , , PUNCT fnp-9165 88 5 si si ADJ fnp-9165 88 6 - - ADJ fnp-9165 88 7 unit unit NOUN fnp-9165 88 8 - - PUNCT fnp-9165 88 9 standardized standardized ADJ fnp-9165 88 10 , , PUNCT fnp-9165 88 11 low low ADJ fnp-9165 88 12 - - PUNCT fnp-9165 88 13 latency latency NOUN fnp-9165 88 14 pathology pathology NOUN fnp-9165 88 15 slide slide NOUN fnp-9165 88 16 analysis analysis NOUN fnp-9165 88 17 with with ADP fnp-9165 88 18 potential potential NOUN fnp-9165 88 19 to to PART fnp-9165 88 20 reduce reduce VERB fnp-9165 88 21 inter inter ADJ fnp-9165 88 22 - - ADJ fnp-9165 88 23 observer observer ADJ fnp-9165 88 24 variability variability NOUN fnp-9165 88 25 , , PUNCT fnp-9165 88 26 improve improve VERB fnp-9165 88 27 accuracy accuracy NOUN fnp-9165 88 28 , , PUNCT fnp-9165 88 29 and and CCONJ fnp-9165 88 30 increase increase VERB fnp-9165 88 31 efficiency efficiency NOUN fnp-9165 88 32 . . PUNCT fnp-9165 89 1 prospective prospective ADJ fnp-9165 89 2 multicenter multicenter NOUN fnp-9165 89 3 evaluation evaluation NOUN fnp-9165 89 4 is be AUX fnp-9165 89 5 warranted warrant VERB fnp-9165 89 6 for for ADP fnp-9165 89 7 widespread widespread ADJ fnp-9165 89 8 use use NOUN fnp-9165 89 9 . . PUNCT fnp-9165 89 10     SPACE fnp-9165 90 1 abstract abstract ADJ fnp-9165 90 2 9 9 NUM fnp-9165 90 3 free free ADJ fnp-9165 90 4 neuropathol neuropathol NOUN fnp-9165 90 5 6:23:13 6:23:13 NUM fnp-9165 90 6 validation validation NOUN fnp-9165 90 7 framework framework NOUN fnp-9165 90 8 for for ADP fnp-9165 90 9 an an DET fnp-9165 90 10 ai ai ADJ fnp-9165 90 11 decision decision NOUN fnp-9165 90 12 support support NOUN fnp-9165 90 13 tool tool NOUN fnp-9165 90 14 in in ADP fnp-9165 90 15 intraoperative intraoperative ADJ fnp-9165 90 16 neuropathology neuropathology NOUN fnp-9165 90 17 : : PUNCT fnp-9165 90 18 protocol protocol NOUN fnp-9165 90 19 for for ADP fnp-9165 90 20 a a DET fnp-9165 90 21 multi multi ADJ fnp-9165 90 22 - - ADJ fnp-9165 90 23 phase phase NOUN fnp-9165 90 24 evaluation evaluation NOUN fnp-9165 90 25 adrienn adrienn ADP fnp-9165 90 26 n. n. PROPN fnp-9165 90 27 bourkas1 bourkas1 PROPN fnp-9165 90 28 , , PUNCT fnp-9165 90 29 shane shane PROPN fnp-9165 90 30 eaton1 eaton1 PROPN fnp-9165 90 31 , , PUNCT fnp-9165 90 32 phedias phedias PROPN fnp-9165 90 33 diamandis1–4 diamandis1–4 PROPN fnp-9165 90 34 department department PROPN fnp-9165 90 35 of of ADP fnp-9165 90 36 laboratory laboratory NOUN fnp-9165 90 37 medicine medicine NOUN fnp-9165 90 38 and and CCONJ fnp-9165 90 39 pathobiology pathobiology NOUN fnp-9165 90 40 , , PUNCT fnp-9165 90 41 university university PROPN fnp-9165 90 42 of of ADP fnp-9165 90 43 toronto toronto PROPN fnp-9165 90 44 , , PUNCT fnp-9165 90 45 toronto toronto PROPN fnp-9165 90 46 , , PUNCT fnp-9165 90 47 canada canada PROPN fnp-9165 90 48 princess princess PROPN fnp-9165 90 49 margaret margaret PROPN fnp-9165 90 50 cancer cancer PROPN fnp-9165 90 51 centre centre PROPN fnp-9165 90 52 , , PUNCT fnp-9165 90 53 toronto toronto PROPN fnp-9165 90 54 , , PUNCT fnp-9165 90 55 canada canada PROPN fnp-9165 90 56 department department PROPN fnp-9165 90 57 of of ADP fnp-9165 90 58 medical medical ADJ fnp-9165 90 59 biophysics biophysic NOUN fnp-9165 90 60 , , PUNCT fnp-9165 90 61 university university PROPN fnp-9165 90 62 of of ADP fnp-9165 90 63 toronto toronto PROPN fnp-9165 90 64 , , PUNCT fnp-9165 90 65 toronto toronto PROPN fnp-9165 90 66 , , PUNCT fnp-9165 90 67 canada canada PROPN fnp-9165 90 68 laboratory laboratory PROPN fnp-9165 90 69 medicine medicine PROPN fnp-9165 90 70 program program PROPN fnp-9165 90 71 , , PUNCT fnp-9165 90 72 department department NOUN fnp-9165 90 73 of of ADP fnp-9165 90 74 pathology pathology PROPN fnp-9165 90 75 , , PUNCT fnp-9165 90 76 university university NOUN fnp-9165 90 77 health health NOUN fnp-9165 90 78 network network NOUN fnp-9165 90 79 , , PUNCT fnp-9165 90 80 toronto toronto PROPN fnp-9165 90 81 , , PUNCT fnp-9165 90 82 canada canada PROPN fnp-9165 90 83 intraoperative intraoperative ADJ fnp-9165 90 84 consultations consultation NOUN fnp-9165 90 85 ( ( PUNCT fnp-9165 90 86 ioc ioc NOUN fnp-9165 90 87 ) ) PUNCT fnp-9165 90 88 for for ADP fnp-9165 90 89 neurosurgical neurosurgical ADJ fnp-9165 90 90 cases case NOUN fnp-9165 90 91 rely rely VERB fnp-9165 90 92 on on ADP fnp-9165 90 93 rapid rapid ADJ fnp-9165 90 94 assessment assessment NOUN fnp-9165 90 95 of of ADP fnp-9165 90 96 h&e h&e PROPN fnp-9165 90 97 - - PUNCT fnp-9165 90 98 stained stain VERB fnp-9165 90 99 frozen frozen ADJ fnp-9165 90 100 sections section NOUN fnp-9165 90 101 and and CCONJ fnp-9165 90 102 cytologic cytologic ADJ fnp-9165 90 103 preparations preparation NOUN fnp-9165 90 104 , , PUNCT fnp-9165 90 105 often often ADV fnp-9165 90 106 under under ADP fnp-9165 90 107 time time NOUN fnp-9165 90 108 pressure pressure NOUN fnp-9165 90 109 and and CCONJ fnp-9165 90 110 with with ADP fnp-9165 90 111 variable variable ADJ fnp-9165 90 112 tissue tissue NOUN fnp-9165 90 113 quality quality NOUN fnp-9165 90 114 . . PUNCT fnp-9165 91 1 we we PRON fnp-9165 91 2 describe describe VERB fnp-9165 91 3 a a DET fnp-9165 91 4 validation validation NOUN fnp-9165 91 5 framework framework NOUN fnp-9165 91 6 for for ADP fnp-9165 91 7 evaluating evaluate VERB fnp-9165 91 8 onsightpathology onsightpathology NOUN fnp-9165 91 9 , , PUNCT fnp-9165 91 10 an an DET fnp-9165 91 11 open open ADJ fnp-9165 91 12 and and CCONJ fnp-9165 91 13 platform platform NOUN fnp-9165 91 14 - - PUNCT fnp-9165 91 15 agnostic agnostic ADJ fnp-9165 91 16 artificial artificial ADJ fnp-9165 91 17 intelligence intelligence NOUN fnp-9165 91 18 ( ( PUNCT fnp-9165 91 19 ai ai NOUN fnp-9165 91 20 ) ) PUNCT fnp-9165 91 21 tool tool NOUN fnp-9165 91 22 developed develop VERB fnp-9165 91 23 to to PART fnp-9165 91 24 classify classify VERB fnp-9165 91 25 intraoperative intraoperative ADJ fnp-9165 91 26 digital digital ADJ fnp-9165 91 27 slides slide NOUN fnp-9165 91 28 into into ADP fnp-9165 91 29 five five NUM fnp-9165 91 30 diagnostic diagnostic ADJ fnp-9165 91 31 categories category NOUN fnp-9165 91 32 : : PUNCT fnp-9165 91 33 glioma glioma NOUN fnp-9165 91 34 , , PUNCT fnp-9165 91 35 epithelioid epithelioid NOUN fnp-9165 91 36 , , PUNCT fnp-9165 91 37 meningeal meningeal NOUN fnp-9165 91 38 , , PUNCT fnp-9165 91 39 schwannoma schwannoma ADJ fnp-9165 91 40 , , PUNCT fnp-9165 91 41 and and CCONJ fnp-9165 91 42 normal normal ADJ fnp-9165 91 43 / / SYM fnp-9165 91 44 reactive reactive ADJ fnp-9165 91 45 tissue tissue NOUN fnp-9165 91 46 . . PUNCT fnp-9165 92 1 in in ADP fnp-9165 92 2 the the DET fnp-9165 92 3 pilot pilot NOUN fnp-9165 92 4 phase phase NOUN fnp-9165 92 5 , , PUNCT fnp-9165 92 6 10–20 10–20 NUM fnp-9165 92 7 representative representative ADJ fnp-9165 92 8 cases case NOUN fnp-9165 92 9 from from ADP fnp-9165 92 10 each each DET fnp-9165 92 11 class class NOUN fnp-9165 92 12 were be AUX fnp-9165 92 13 selected select VERB fnp-9165 92 14 from from ADP fnp-9165 92 15 archival archival NOUN fnp-9165 92 16 material material NOUN fnp-9165 92 17 , , PUNCT fnp-9165 92 18 and and CCONJ fnp-9165 92 19 50–100 50–100 NUM fnp-9165 92 20 diagnostic diagnostic ADJ fnp-9165 92 21 tiles tile NOUN fnp-9165 92 22 per per ADP fnp-9165 92 23 case case NOUN fnp-9165 92 24 were be AUX fnp-9165 92 25 extracted extract VERB fnp-9165 92 26 using use VERB fnp-9165 92 27 an an DET fnp-9165 92 28 image image NOUN fnp-9165 92 29 feature feature NOUN fnp-9165 92 30 - - PUNCT fnp-9165 92 31 based base VERB fnp-9165 92 32 clustering clustering ADJ fnp-9165 92 33 pipeline pipeline NOUN fnp-9165 92 34 . . PUNCT fnp-9165 93 1 groups group NOUN fnp-9165 93 2 of of ADP fnp-9165 93 3 tiles tile NOUN fnp-9165 93 4 were be AUX fnp-9165 93 5 assigned assign VERB fnp-9165 93 6 coarse coarse ADJ fnp-9165 93 7 labels label NOUN fnp-9165 93 8 ( ( PUNCT fnp-9165 93 9 e.g. e.g. ADV fnp-9165 93 10 , , PUNCT fnp-9165 93 11 glioma glioma NOUN fnp-9165 93 12 , , PUNCT fnp-9165 93 13 artifact artifact NOUN fnp-9165 93 14 ) ) PUNCT fnp-9165 93 15 via via ADP fnp-9165 93 16 visual visual ADJ fnp-9165 93 17 histologic histologic ADJ fnp-9165 93 18 inspection inspection NOUN fnp-9165 93 19 . . PUNCT fnp-9165 94 1 ground ground NOUN fnp-9165 94 2 - - PUNCT fnp-9165 94 3 truth truth NOUN fnp-9165 94 4 diagnoses diagnosis NOUN fnp-9165 94 5 were be AUX fnp-9165 94 6 adjudicated adjudicate VERB fnp-9165 94 7 on on ADP fnp-9165 94 8 formalin formalin NOUN fnp-9165 94 9 - - PUNCT fnp-9165 94 10 fixed fix VERB fnp-9165 94 11 paraffin paraffin NOUN fnp-9165 94 12 - - PUNCT fnp-9165 94 13 embedded embed VERB fnp-9165 94 14 sections section NOUN fnp-9165 94 15 through through ADP fnp-9165 94 16 dual dual ADJ fnp-9165 94 17 - - PUNCT fnp-9165 94 18 review review NOUN fnp-9165 94 19 consensus consensus NOUN fnp-9165 94 20 . . PUNCT fnp-9165 95 1 the the DET fnp-9165 95 2 annotated annotate VERB fnp-9165 95 3 images image NOUN fnp-9165 95 4 will will AUX fnp-9165 95 5 then then ADV fnp-9165 95 6 be be AUX fnp-9165 95 7 used use VERB fnp-9165 95 8 to to PART fnp-9165 95 9 train train VERB fnp-9165 95 10 a a DET fnp-9165 95 11 vision vision NOUN fnp-9165 95 12 transformer transformer NOUN fnp-9165 95 13 model model NOUN fnp-9165 95 14 and and CCONJ fnp-9165 95 15 will will AUX fnp-9165 95 16 be be AUX fnp-9165 95 17 deployed deploy VERB fnp-9165 95 18 using use VERB fnp-9165 95 19 onsightpathology onsightpathology NOUN fnp-9165 95 20 to to PART fnp-9165 95 21 provide provide VERB fnp-9165 95 22 " " PUNCT fnp-9165 95 23 real real ADJ fnp-9165 95 24 - - PUNCT fnp-9165 95 25 time time NOUN fnp-9165 95 26 " " PUNCT fnp-9165 95 27 inferences inference NOUN fnp-9165 95 28 to to PART fnp-9165 95 29 help help VERB fnp-9165 95 30 with with ADP fnp-9165 95 31 intra intra ADJ fnp-9165 95 32 - - ADJ fnp-9165 95 33 operative operative ADJ fnp-9165 95 34 frozen frozen ADJ fnp-9165 95 35 section section NOUN fnp-9165 95 36 analysis analysis NOUN fnp-9165 95 37 . . PUNCT fnp-9165 96 1 the the DET fnp-9165 96 2 tool tool NOUN fnp-9165 96 3 is be AUX fnp-9165 96 4 designed design VERB fnp-9165 96 5 to to PART fnp-9165 96 6 assist assist VERB fnp-9165 96 7 pathologists pathologist NOUN fnp-9165 96 8 by by ADP fnp-9165 96 9 highlighting highlight VERB fnp-9165 96 10 diagnostically diagnostically ADV fnp-9165 96 11 relevant relevant ADJ fnp-9165 96 12 regions region NOUN fnp-9165 96 13 , , PUNCT fnp-9165 96 14 providing provide VERB fnp-9165 96 15 class class NOUN fnp-9165 96 16 probabilities probability NOUN fnp-9165 96 17 , , PUNCT fnp-9165 96 18 and and CCONJ fnp-9165 96 19 flagging flag VERB fnp-9165 96 20 low low ADJ fnp-9165 96 21 - - PUNCT fnp-9165 96 22 confidence confidence NOUN fnp-9165 96 23 areas area NOUN fnp-9165 96 24 for for ADP fnp-9165 96 25 review review NOUN fnp-9165 96 26 . . PUNCT fnp-9165 97 1 this this DET fnp-9165 97 2 approach approach NOUN fnp-9165 97 3 is be AUX fnp-9165 97 4 intended intend VERB fnp-9165 97 5 to to PART fnp-9165 97 6 augment augment VERB fnp-9165 97 7 ioc ioc NOUN fnp-9165 97 8 workflows workflow NOUN fnp-9165 97 9 by by ADP fnp-9165 97 10 improving improve VERB fnp-9165 97 11 confidence confidence NOUN fnp-9165 97 12 , , PUNCT fnp-9165 97 13 reducing reduce VERB fnp-9165 97 14 turnaround turnaround NOUN fnp-9165 97 15 time time NOUN fnp-9165 97 16 , , PUNCT fnp-9165 97 17 and and CCONJ fnp-9165 97 18 standardizing standardize VERB fnp-9165 97 19 interpretation interpretation NOUN fnp-9165 97 20 in in ADP fnp-9165 97 21 time time NOUN fnp-9165 97 22 - - PUNCT fnp-9165 97 23 sensitive sensitive ADJ fnp-9165 97 24 settings setting NOUN fnp-9165 97 25 . . PUNCT fnp-9165 98 1 subsequent subsequent ADJ fnp-9165 98 2 phases phase NOUN fnp-9165 98 3 will will AUX fnp-9165 98 4 assess assess VERB fnp-9165 98 5 onsightpathology onsightpathology NOUN fnp-9165 98 6 ’s ’s PART fnp-9165 98 7 performance performance NOUN fnp-9165 98 8 on on ADP fnp-9165 98 9 external external ADJ fnp-9165 98 10 cohorts cohort NOUN fnp-9165 98 11 and and CCONJ fnp-9165 98 12 in in ADP fnp-9165 98 13 real real ADJ fnp-9165 98 14 - - PUNCT fnp-9165 98 15 time time NOUN fnp-9165 98 16 clinical clinical ADJ fnp-9165 98 17 use use NOUN fnp-9165 98 18 . . PUNCT fnp-9165 98 19     SPACE fnp-9165 99 1 abstract abstract ADJ fnp-9165 99 2 10 10 NUM fnp-9165 99 3 free free ADJ fnp-9165 99 4 neuropathol neuropathol NOUN fnp-9165 99 5 6:23:14 6:23:14 NUM fnp-9165 99 6 an an DET fnp-9165 99 7 internal internal ADJ fnp-9165 99 8 audit audit NOUN fnp-9165 99 9 of of ADP fnp-9165 99 10 neuropathology neuropathology NOUN fnp-9165 99 11 consultation consultation NOUN fnp-9165 99 12 for for ADP fnp-9165 99 13 autopsies autopsy NOUN fnp-9165 99 14 at at ADP fnp-9165 99 15 the the DET fnp-9165 99 16 london london PROPN fnp-9165 99 17 health health PROPN fnp-9165 99 18 sciences sciences PROPN fnp-9165 99 19 centre centre PROPN fnp-9165 99 20 – – PUNCT fnp-9165 99 21 a a DET fnp-9165 99 22 quality quality NOUN fnp-9165 99 23 improvement improvement NOUN fnp-9165 99 24 project project NOUN fnp-9165 99 25 hao hao PROPN fnp-9165 99 26 li1,2 li1,2 PROPN fnp-9165 99 27 , , PUNCT fnp-9165 99 28 qi qi PROPN fnp-9165 99 29 zhang1,2 zhang1,2 PROPN fnp-9165 99 30 pathology pathology NOUN fnp-9165 99 31 and and CCONJ fnp-9165 99 32 laboratory laboratory NOUN fnp-9165 99 33 medicine medicine NOUN fnp-9165 99 34 , , PUNCT fnp-9165 99 35 london london PROPN fnp-9165 99 36 health health PROPN fnp-9165 99 37 sciences sciences PROPN fnp-9165 99 38 centre centre PROPN fnp-9165 99 39 , , PUNCT fnp-9165 99 40 london london PROPN fnp-9165 99 41 , , PUNCT fnp-9165 99 42 canada canada PROPN fnp-9165 99 43 schulich schulich PROPN fnp-9165 99 44 school school NOUN fnp-9165 99 45 of of ADP fnp-9165 99 46 medicine medicine NOUN fnp-9165 99 47 and and CCONJ fnp-9165 99 48 dentistry dentistry NOUN fnp-9165 99 49 , , PUNCT fnp-9165 99 50 western western ADJ fnp-9165 99 51 university university NOUN fnp-9165 99 52 , , PUNCT fnp-9165 99 53 london london PROPN fnp-9165 99 54 , , PUNCT fnp-9165 99 55 canada canada PROPN fnp-9165 99 56 in in ADP fnp-9165 99 57 autopsy autopsy ADJ fnp-9165 99 58 , , PUNCT fnp-9165 99 59 neuropathological neuropathological ADJ fnp-9165 99 60 workups workup NOUN fnp-9165 99 61 tend tend VERB fnp-9165 99 62 to to PART fnp-9165 99 63 be be AUX fnp-9165 99 64 relatively relatively ADV fnp-9165 99 65 extensive extensive ADJ fnp-9165 99 66 , , PUNCT fnp-9165 99 67 requiring require VERB fnp-9165 99 68 more more ADJ fnp-9165 99 69 tissue tissue NOUN fnp-9165 99 70 sampling sampling NOUN fnp-9165 99 71 , , PUNCT fnp-9165 99 72 ancillary ancillary ADJ fnp-9165 99 73 testing testing NOUN fnp-9165 99 74 , , PUNCT fnp-9165 99 75 and and CCONJ fnp-9165 99 76 examination examination NOUN fnp-9165 99 77 time time NOUN fnp-9165 99 78 compared compare VERB fnp-9165 99 79 to to ADP fnp-9165 99 80 other other ADJ fnp-9165 99 81 body body NOUN fnp-9165 99 82 systems system NOUN fnp-9165 99 83 . . PUNCT fnp-9165 100 1 as as SCONJ fnp-9165 100 2 london london PROPN fnp-9165 100 3 health health PROPN fnp-9165 100 4 sciences sciences PROPN fnp-9165 100 5 centre centre PROPN fnp-9165 100 6 ( ( PUNCT fnp-9165 100 7 lhsc lhsc PROPN fnp-9165 100 8 ) ) PUNCT fnp-9165 100 9 is be AUX fnp-9165 100 10 a a DET fnp-9165 100 11 high high ADJ fnp-9165 100 12 - - PUNCT fnp-9165 100 13 volume volume NOUN fnp-9165 100 14 autopsy autopsy ADJ fnp-9165 100 15 institution institution NOUN fnp-9165 100 16 , , PUNCT fnp-9165 100 17 in in ADP fnp-9165 100 18 this this DET fnp-9165 100 19 quality quality NOUN fnp-9165 100 20 improvement improvement NOUN fnp-9165 100 21 project project NOUN fnp-9165 100 22 we we PRON fnp-9165 100 23 present present VERB fnp-9165 100 24 the the DET fnp-9165 100 25 utility utility NOUN fnp-9165 100 26 of of ADP fnp-9165 100 27 a a DET fnp-9165 100 28 centralized centralized ADJ fnp-9165 100 29 neuropathology neuropathology NOUN fnp-9165 100 30 medical medical ADJ fnp-9165 100 31 ( ( PUNCT fnp-9165 100 32 hospital hospital NOUN fnp-9165 100 33 ) ) PUNCT fnp-9165 100 34 / / SYM fnp-9165 100 35 biobank biobank ADJ fnp-9165 100 36 autopsy autopsy ADJ fnp-9165 100 37 database database NOUN fnp-9165 100 38 as as ADP fnp-9165 100 39 an an DET fnp-9165 100 40 internal internal ADJ fnp-9165 100 41 audit audit NOUN fnp-9165 100 42 for for ADP fnp-9165 100 43 laboratory laboratory NOUN fnp-9165 100 44 management management NOUN fnp-9165 100 45 purposes purpose NOUN fnp-9165 100 46 . . PUNCT fnp-9165 101 1 the the DET fnp-9165 101 2 database database NOUN fnp-9165 101 3 is be AUX fnp-9165 101 4 a a DET fnp-9165 101 5 simple simple ADJ fnp-9165 101 6 digital digital ADJ fnp-9165 101 7 spreadsheet spreadsheet NOUN fnp-9165 101 8 recording recording NOUN fnp-9165 101 9 retrospectively retrospectively ADV fnp-9165 101 10 , , PUNCT fnp-9165 101 11 on on ADP fnp-9165 101 12 all all DET fnp-9165 101 13 lhsc lhsc PROPN fnp-9165 101 14 medical medical ADJ fnp-9165 101 15 and and CCONJ fnp-9165 101 16 biobank biobank ADJ fnp-9165 101 17 neuropathological neuropathological ADJ fnp-9165 101 18 autopsy autopsy ADJ fnp-9165 101 19 consultations consultation NOUN fnp-9165 101 20 from from ADP fnp-9165 101 21 2005 2005 NUM fnp-9165 101 22 to to ADP fnp-9165 101 23 2023 2023 NUM fnp-9165 101 24 , , PUNCT fnp-9165 101 25 the the DET fnp-9165 101 26 following follow VERB fnp-9165 101 27 parameters parameter NOUN fnp-9165 101 28 : : PUNCT fnp-9165 101 29 case case NOUN fnp-9165 101 30 type type NOUN fnp-9165 101 31 ( ( PUNCT fnp-9165 101 32 routine routine ADJ fnp-9165 101 33 medical medical ADJ fnp-9165 101 34 vs. vs. X fnp-9165 101 35 biobank biobank NOUN fnp-9165 101 36 ) ) PUNCT fnp-9165 101 37 , , PUNCT fnp-9165 101 38 in in ADP fnp-9165 101 39 - - PUNCT fnp-9165 101 40 house house NOUN fnp-9165 101 41 vs. vs. ADP fnp-9165 101 42 externally externally ADV fnp-9165 101 43 referred refer VERB fnp-9165 101 44 , , PUNCT fnp-9165 101 45 reason reason NOUN fnp-9165 101 46 for for ADP fnp-9165 101 47 neuropathology neuropathology NOUN fnp-9165 101 48 consultation consultation NOUN fnp-9165 101 49 , , PUNCT fnp-9165 101 50 specimens specimen NOUN fnp-9165 101 51 examined examine VERB fnp-9165 101 52 ( ( PUNCT fnp-9165 102 1 eg eg NOUN fnp-9165 102 2 . . PUNCT fnp-9165 102 3 brain brain NOUN fnp-9165 102 4 , , PUNCT fnp-9165 102 5 spinal spinal ADJ fnp-9165 102 6 cord cord NOUN fnp-9165 102 7 , , PUNCT fnp-9165 102 8 muscle muscle NOUN fnp-9165 102 9 ) ) PUNCT fnp-9165 102 10 , , PUNCT fnp-9165 102 11 age age NOUN fnp-9165 102 12 at at ADP fnp-9165 102 13 death death NOUN fnp-9165 102 14 , , PUNCT fnp-9165 102 15 dates date NOUN fnp-9165 102 16 of of ADP fnp-9165 102 17 autopsy autopsy ADJ fnp-9165 102 18 / / SYM fnp-9165 102 19 brain brain NOUN fnp-9165 102 20 cut cut NOUN fnp-9165 102 21 / / SYM fnp-9165 102 22 sign sign NOUN fnp-9165 102 23 - - PUNCT fnp-9165 102 24 out out NOUN fnp-9165 102 25 , , PUNCT fnp-9165 102 26 involvement involvement NOUN fnp-9165 102 27 of of ADP fnp-9165 102 28 trainees trainee NOUN fnp-9165 102 29 , , PUNCT fnp-9165 102 30 and and CCONJ fnp-9165 102 31 final final ADJ fnp-9165 102 32 diagnosis diagnosis NOUN fnp-9165 102 33 . . PUNCT fnp-9165 103 1 once once ADV fnp-9165 103 2 established establish VERB fnp-9165 103 3 , , PUNCT fnp-9165 103 4 the the DET fnp-9165 103 5 database database NOUN fnp-9165 103 6 is be AUX fnp-9165 103 7 easy easy ADJ fnp-9165 103 8 to to PART fnp-9165 103 9 utilize utilize VERB fnp-9165 103 10 , , PUNCT fnp-9165 103 11 and and CCONJ fnp-9165 103 12 multiple multiple ADJ fnp-9165 103 13 laboratory laboratory NOUN fnp-9165 103 14 management management NOUN fnp-9165 103 15 statistics statistic NOUN fnp-9165 103 16 can can AUX fnp-9165 103 17 be be AUX fnp-9165 103 18 mined mine VERB fnp-9165 103 19 using use VERB fnp-9165 103 20 basic basic ADJ fnp-9165 103 21 spreadsheet spreadsheet NOUN fnp-9165 103 22 functions function NOUN fnp-9165 103 23 . . PUNCT fnp-9165 104 1 these these PRON fnp-9165 104 2 include include VERB fnp-9165 104 3 volume volume NOUN fnp-9165 104 4 trends trend NOUN fnp-9165 104 5 of of ADP fnp-9165 104 6 case case NOUN fnp-9165 104 7 types type NOUN fnp-9165 104 8 over over ADP fnp-9165 104 9 time time NOUN fnp-9165 104 10 , , PUNCT fnp-9165 104 11 proportions proportion NOUN fnp-9165 104 12 of of ADP fnp-9165 104 13 different different ADJ fnp-9165 104 14 reasons reason NOUN fnp-9165 104 15 for for ADP fnp-9165 104 16 consultation consultation NOUN fnp-9165 104 17 , , PUNCT fnp-9165 104 18 and and CCONJ fnp-9165 104 19 turn turn NOUN fnp-9165 104 20 - - PUNCT fnp-9165 104 21 around around ADP fnp-9165 104 22 - - PUNCT fnp-9165 104 23 time time NOUN fnp-9165 104 24 as as ADP fnp-9165 104 25 a a DET fnp-9165 104 26 function function NOUN fnp-9165 104 27 of of ADP fnp-9165 104 28 other other ADJ fnp-9165 104 29 parameters parameter NOUN fnp-9165 104 30 such such ADJ fnp-9165 104 31 as as ADP fnp-9165 104 32 diagnosis diagnosis NOUN fnp-9165 104 33 , , PUNCT fnp-9165 104 34 deceased deceased ADJ fnp-9165 104 35 age age NOUN fnp-9165 104 36 , , PUNCT fnp-9165 104 37 trainee trainee NOUN fnp-9165 104 38 involvement involvement NOUN fnp-9165 104 39 , , PUNCT fnp-9165 104 40 among among ADP fnp-9165 104 41 others other NOUN fnp-9165 104 42 . . PUNCT fnp-9165 105 1 the the DET fnp-9165 105 2 practical practical ADJ fnp-9165 105 3 applications application NOUN fnp-9165 105 4 of of ADP fnp-9165 105 5 an an DET fnp-9165 105 6 institutional institutional ADJ fnp-9165 105 7 neuropathology neuropathology NOUN fnp-9165 105 8 autopsy autopsy ADJ fnp-9165 105 9 database database NOUN fnp-9165 105 10 for for ADP fnp-9165 105 11 internal internal ADJ fnp-9165 105 12 audit audit NOUN fnp-9165 105 13 and and CCONJ fnp-9165 105 14 laboratory laboratory NOUN fnp-9165 105 15 management management NOUN fnp-9165 105 16 are be AUX fnp-9165 105 17 many many ADJ fnp-9165 105 18 , , PUNCT fnp-9165 105 19 including include VERB fnp-9165 105 20 guidance guidance NOUN fnp-9165 105 21 on on ADP fnp-9165 105 22 resource resource NOUN fnp-9165 105 23 management management NOUN fnp-9165 105 24 based base VERB fnp-9165 105 25 on on ADP fnp-9165 105 26 consultation consultation NOUN fnp-9165 105 27 patterns pattern NOUN fnp-9165 105 28 , , PUNCT fnp-9165 105 29 technical technical ADJ fnp-9165 105 30 expertise expertise NOUN fnp-9165 105 31 based base VERB fnp-9165 105 32 on on ADP fnp-9165 105 33 specimen speciman NOUN fnp-9165 105 34 types type NOUN fnp-9165 105 35 , , PUNCT fnp-9165 105 36 analysis analysis NOUN fnp-9165 105 37 of of ADP fnp-9165 105 38 factors factor NOUN fnp-9165 105 39 influencing influence VERB fnp-9165 105 40 turn turn NOUN fnp-9165 105 41 - - PUNCT fnp-9165 105 42 around around ADP fnp-9165 105 43 - - PUNCT fnp-9165 105 44 time time NOUN fnp-9165 105 45 , , PUNCT fnp-9165 105 46 and and CCONJ fnp-9165 105 47 guiding guide VERB fnp-9165 105 48 curriculum curriculum NOUN fnp-9165 105 49 design design NOUN fnp-9165 105 50 in in ADP fnp-9165 105 51 neuropathology neuropathology NOUN fnp-9165 105 52 education education NOUN fnp-9165 105 53 . . PUNCT fnp-9165 106 1 future future ADJ fnp-9165 106 2 directions direction NOUN fnp-9165 106 3 include include VERB fnp-9165 106 4 extending extend VERB fnp-9165 106 5 such such ADJ fnp-9165 106 6 strategy strategy NOUN fnp-9165 106 7 to to ADP fnp-9165 106 8 forensic forensic VERB fnp-9165 106 9 / / SYM fnp-9165 106 10 medical medical ADJ fnp-9165 106 11 - - PUNCT fnp-9165 106 12 legal legal ADJ fnp-9165 106 13 autopsies autopsy NOUN fnp-9165 106 14 , , PUNCT fnp-9165 106 15 which which PRON fnp-9165 106 16 would would AUX fnp-9165 106 17 also also ADV fnp-9165 106 18 be be AUX fnp-9165 106 19 useful useful ADJ fnp-9165 106 20 in in ADP fnp-9165 106 21 analyzing analyze VERB fnp-9165 106 22 contributions contribution NOUN fnp-9165 106 23 of of ADP fnp-9165 106 24 neuropathological neuropathological ADJ fnp-9165 106 25 consultations consultation NOUN fnp-9165 106 26 in in ADP fnp-9165 106 27 addressing address VERB fnp-9165 106 28 the the DET fnp-9165 106 29 forensic forensic ADJ fnp-9165 106 30 question question NOUN fnp-9165 106 31 . . PUNCT fnp-9165 106 32     SPACE fnp-9165 107 1 abstract abstract ADJ fnp-9165 107 2 11 11 NUM fnp-9165 107 3 free free ADJ fnp-9165 107 4 neuropathol neuropathol NOUN fnp-9165 107 5 6:23:15 6:23:15 NUM fnp-9165 107 6 ischemic ischemic ADJ fnp-9165 107 7 stroke stroke NOUN fnp-9165 107 8 in in ADP fnp-9165 107 9 hypereosinophilic hypereosinophilic ADJ fnp-9165 107 10 syndrome syndrome NOUN fnp-9165 107 11 : : PUNCT fnp-9165 107 12 a a DET fnp-9165 107 13 clinicopathologic clinicopathologic ADJ fnp-9165 107 14 study study NOUN fnp-9165 107 15 of of ADP fnp-9165 107 16 two two NUM fnp-9165 107 17 cases case NOUN fnp-9165 107 18 karina karina PROPN fnp-9165 107 19 c. c. PROPN fnp-9165 107 20 martin1 martin1 PROPN fnp-9165 107 21 , , PUNCT fnp-9165 107 22 dan dan PROPN fnp-9165 107 23 straathof2 straathof2 PROPN fnp-9165 107 24 , , PUNCT fnp-9165 107 25 chi chi PROPN fnp-9165 107 26 lai3 lai3 PROPN fnp-9165 107 27 , , PUNCT fnp-9165 107 28 harry harry PROPN fnp-9165 107 29 v. v. ADP fnp-9165 107 30 vinters4 vinters4 PROPN fnp-9165 107 31 department department PROPN fnp-9165 107 32 of of ADP fnp-9165 107 33 pathology pathology PROPN fnp-9165 107 34 and and CCONJ fnp-9165 107 35 laboratory laboratory NOUN fnp-9165 107 36 medicine medicine NOUN fnp-9165 107 37 , , PUNCT fnp-9165 107 38 faculty faculty NOUN fnp-9165 107 39 of of ADP fnp-9165 107 40 medicine medicine NOUN fnp-9165 107 41 , , PUNCT fnp-9165 107 42 university university NOUN fnp-9165 107 43 of of ADP fnp-9165 107 44 british british PROPN fnp-9165 107 45 columbia columbia PROPN fnp-9165 107 46 , , PUNCT fnp-9165 107 47 vancouver vancouver PROPN fnp-9165 107 48 , , PUNCT fnp-9165 107 49 canada canada PROPN fnp-9165 107 50 fraser fraser PROPN fnp-9165 107 51 health health PROPN fnp-9165 107 52 department department PROPN fnp-9165 107 53 of of ADP fnp-9165 107 54 laboratory laboratory PROPN fnp-9165 107 55 medicine medicine PROPN fnp-9165 107 56 & & CCONJ fnp-9165 107 57 pathology pathology PROPN fnp-9165 107 58 , , PUNCT fnp-9165 107 59 royal royal ADJ fnp-9165 107 60 columbian columbian ADJ fnp-9165 107 61 hospital hospital NOUN fnp-9165 107 62 , , PUNCT fnp-9165 107 63 new new ADJ fnp-9165 107 64 westminster westminster NOUN fnp-9165 107 65 , , PUNCT fnp-9165 107 66 canada canada PROPN fnp-9165 107 67 providence providence PROPN fnp-9165 107 68 health health PROPN fnp-9165 107 69 , , PUNCT fnp-9165 107 70 st st PROPN fnp-9165 107 71 . . PROPN fnp-9165 107 72 paul paul PROPN fnp-9165 107 73 ’s ’s PART fnp-9165 107 74 hospital hospital NOUN fnp-9165 107 75 , , PUNCT fnp-9165 107 76 university university NOUN fnp-9165 107 77 of of ADP fnp-9165 107 78 british british PROPN fnp-9165 107 79 columbia columbia PROPN fnp-9165 107 80 , , PUNCT fnp-9165 107 81 department department PROPN fnp-9165 107 82 of of ADP fnp-9165 107 83 pathology pathology PROPN fnp-9165 107 84 & & CCONJ fnp-9165 107 85 laboratory laboratory PROPN fnp-9165 107 86 medicine medicine PROPN fnp-9165 107 87 , , PUNCT fnp-9165 107 88 vancouver vancouver PROPN fnp-9165 107 89 , , PUNCT fnp-9165 107 90 canada canada PROPN fnp-9165 107 91 departments department NOUN fnp-9165 107 92 of of ADP fnp-9165 107 93 pathology pathology NOUN fnp-9165 107 94 and and CCONJ fnp-9165 107 95 laboratory laboratory NOUN fnp-9165 107 96 medicine medicine NOUN fnp-9165 107 97 ( ( PUNCT fnp-9165 107 98 neuropathology neuropathology NOUN fnp-9165 107 99 ) ) PUNCT fnp-9165 107 100 and and CCONJ fnp-9165 107 101 neurology neurology NOUN fnp-9165 107 102 , , PUNCT fnp-9165 107 103 david david PROPN fnp-9165 107 104 geffen geffen PROPN fnp-9165 107 105 school school PROPN fnp-9165 107 106 of of ADP fnp-9165 107 107 medicine medicine NOUN fnp-9165 107 108 , , PUNCT fnp-9165 107 109 university university PROPN fnp-9165 107 110 of of ADP fnp-9165 107 111 california california PROPN fnp-9165 107 112 , , PUNCT fnp-9165 107 113 los los PROPN fnp-9165 107 114 angeles angeles PROPN fnp-9165 107 115 , , PUNCT fnp-9165 107 116 usa usa PROPN fnp-9165 107 117 ischemic ischemic ADJ fnp-9165 107 118 stroke stroke NOUN fnp-9165 107 119 is be AUX fnp-9165 107 120 a a DET fnp-9165 107 121 rare rare ADJ fnp-9165 107 122 complication complication NOUN fnp-9165 107 123 of of ADP fnp-9165 107 124 hypereosinophilic hypereosinophilic ADJ fnp-9165 107 125 syndrome syndrome NOUN fnp-9165 107 126 ( ( PUNCT fnp-9165 107 127 he he PRON fnp-9165 107 128 s s PART fnp-9165 107 129 ) ) PUNCT fnp-9165 107 130 . . PUNCT fnp-9165 108 1 manifestations manifestation NOUN fnp-9165 108 2 of of ADP fnp-9165 108 3 stroke stroke NOUN fnp-9165 108 4 in in ADP fnp-9165 108 5 he he PRON fnp-9165 108 6 s s VERB fnp-9165 108 7 have have AUX fnp-9165 108 8 been be AUX fnp-9165 108 9 described describe VERB fnp-9165 108 10 mainly mainly ADV fnp-9165 108 11 in in ADP fnp-9165 108 12 the the DET fnp-9165 108 13 radiologic radiologic ADJ fnp-9165 108 14 literature literature NOUN fnp-9165 108 15 ; ; PUNCT fnp-9165 108 16 however however ADV fnp-9165 108 17 , , PUNCT fnp-9165 108 18 the the DET fnp-9165 108 19 pathologic pathologic ADJ fnp-9165 108 20 characterization characterization NOUN fnp-9165 108 21 of of ADP fnp-9165 108 22 central central ADJ fnp-9165 108 23 nervous nervous ADJ fnp-9165 108 24 system system NOUN fnp-9165 108 25 ( ( PUNCT fnp-9165 108 26 cns cns NOUN fnp-9165 108 27 ) ) PUNCT fnp-9165 108 28 involvement involvement NOUN fnp-9165 108 29 in in ADP fnp-9165 108 30 he he PRON fnp-9165 108 31 s s VERB fnp-9165 108 32 is be AUX fnp-9165 108 33 limited limited ADJ fnp-9165 108 34 . . PUNCT fnp-9165 109 1 we we PRON fnp-9165 109 2 describe describe VERB fnp-9165 109 3 two two NUM fnp-9165 109 4 patients patient NOUN fnp-9165 109 5 who who PRON fnp-9165 109 6 presented present VERB fnp-9165 109 7 to to ADP fnp-9165 109 8 hospital hospital NOUN fnp-9165 109 9 with with ADP fnp-9165 109 10 systemic systemic ADJ fnp-9165 109 11 symptoms symptom NOUN fnp-9165 109 12 and and CCONJ fnp-9165 109 13 were be AUX fnp-9165 109 14 found find VERB fnp-9165 109 15 to to PART fnp-9165 109 16 have have VERB fnp-9165 109 17 peripheral peripheral ADJ fnp-9165 109 18 blood blood NOUN fnp-9165 109 19 hypereosinophilia hypereosinophilia NOUN fnp-9165 109 20 . . PUNCT fnp-9165 110 1 thorough thorough ADJ fnp-9165 110 2 investigations investigation NOUN fnp-9165 110 3 for for ADP fnp-9165 110 4 primary primary ADJ fnp-9165 110 5 and and CCONJ fnp-9165 110 6 secondary secondary ADJ fnp-9165 110 7 etiologies etiology NOUN fnp-9165 110 8 of of ADP fnp-9165 110 9 hypereosinophilia hypereosinophilia NOUN fnp-9165 110 10 were be AUX fnp-9165 110 11 negative negative ADJ fnp-9165 110 12 . . PUNCT fnp-9165 111 1 both both DET fnp-9165 111 2 patients patient NOUN fnp-9165 111 3 subsequently subsequently ADV fnp-9165 111 4 suffered suffer VERB fnp-9165 111 5 catastrophic catastrophic ADJ fnp-9165 111 6 strokes stroke NOUN fnp-9165 111 7 and and CCONJ fnp-9165 111 8 died die VERB fnp-9165 111 9 despite despite SCONJ fnp-9165 111 10 therapy therapy NOUN fnp-9165 111 11 and and CCONJ fnp-9165 111 12 resuscitative resuscitative ADJ fnp-9165 111 13 efforts effort NOUN fnp-9165 111 14 . . PUNCT fnp-9165 112 1 pertinent pertinent ADJ fnp-9165 112 2 general general ADJ fnp-9165 112 3 autopsy autopsy ADJ fnp-9165 112 4 findings finding NOUN fnp-9165 112 5 in in ADP fnp-9165 112 6 both both DET fnp-9165 112 7 cases case NOUN fnp-9165 112 8 included include VERB fnp-9165 112 9 the the DET fnp-9165 112 10 presence presence NOUN fnp-9165 112 11 of of ADP fnp-9165 112 12 intraventricular intraventricular ADJ fnp-9165 112 13 cardiac cardiac ADJ fnp-9165 112 14 thrombi thrombi NOUN fnp-9165 112 15 . . PUNCT fnp-9165 113 1 post post ADJ fnp-9165 113 2 - - ADJ fnp-9165 113 3 mortem mortem ADJ fnp-9165 113 4 neuropathologic neuropathologic ADJ fnp-9165 113 5 examination examination NOUN fnp-9165 113 6 demonstrated demonstrate VERB fnp-9165 113 7 a a DET fnp-9165 113 8 multi multi ADJ fnp-9165 113 9 - - ADJ fnp-9165 113 10 territorial territorial ADJ fnp-9165 113 11 embolic embolic ADJ fnp-9165 113 12 infarct infarct NOUN fnp-9165 113 13 pattern pattern NOUN fnp-9165 113 14 in in ADP fnp-9165 113 15 patient patient NOUN fnp-9165 113 16 1 1 NUM fnp-9165 113 17 and and CCONJ fnp-9165 113 18 a a DET fnp-9165 113 19 watershed watershed ADJ fnp-9165 113 20 infarct infarct NOUN fnp-9165 113 21 pattern pattern NOUN fnp-9165 113 22 in in ADP fnp-9165 113 23 patient patient ADJ fnp-9165 113 24 2 2 NUM fnp-9165 113 25 . . PUNCT fnp-9165 113 26 microscopic microscopic ADJ fnp-9165 113 27 features feature NOUN fnp-9165 113 28 included include VERB fnp-9165 113 29 the the DET fnp-9165 113 30 presence presence NOUN fnp-9165 113 31 of of ADP fnp-9165 113 32 microabscesses microabscesse NOUN fnp-9165 113 33 consisting consist VERB fnp-9165 113 34 of of ADP fnp-9165 113 35 a a DET fnp-9165 113 36 disproportionately disproportionately ADV fnp-9165 113 37 large large ADJ fnp-9165 113 38 number number NOUN fnp-9165 113 39 of of ADP fnp-9165 113 40 eosinophils eosinophil NOUN fnp-9165 113 41 and and CCONJ fnp-9165 113 42 infarcts infarct NOUN fnp-9165 113 43 associated associate VERB fnp-9165 113 44 with with ADP fnp-9165 113 45 blood blood NOUN fnp-9165 113 46 vessels vessel NOUN fnp-9165 113 47 showing show VERB fnp-9165 113 48 occlusive occlusive ADJ fnp-9165 113 49 thrombi thrombi NOUN fnp-9165 113 50 with with ADP fnp-9165 113 51 surrounding surround VERB fnp-9165 113 52 eosinophils eosinophil NOUN fnp-9165 113 53 . . PUNCT fnp-9165 114 1 in in ADP fnp-9165 114 2 summary summary NOUN fnp-9165 114 3 , , PUNCT fnp-9165 114 4 we we PRON fnp-9165 114 5 present present VERB fnp-9165 114 6 two two NUM fnp-9165 114 7 post post ADJ fnp-9165 114 8 - - ADJ fnp-9165 114 9 mortem mortem ADJ fnp-9165 114 10 neuropathologic neuropathologic ADJ fnp-9165 114 11 examinations examination NOUN fnp-9165 114 12 of of ADP fnp-9165 114 13 patients patient NOUN fnp-9165 114 14 exhibiting exhibit VERB fnp-9165 114 15 cns cns NOUN fnp-9165 114 16 infarcts infarct NOUN fnp-9165 114 17 associated associate VERB fnp-9165 114 18 with with ADP fnp-9165 114 19 he he PRON fnp-9165 114 20 s s PART fnp-9165 114 21 , , PUNCT fnp-9165 114 22 discuss discuss VERB fnp-9165 114 23 potential potential ADJ fnp-9165 114 24 pathomechanisms pathomechanism NOUN fnp-9165 114 25 , , PUNCT fnp-9165 114 26 and and CCONJ fnp-9165 114 27 review review VERB fnp-9165 114 28 the the DET fnp-9165 114 29 literature literature NOUN fnp-9165 114 30 on on ADP fnp-9165 114 31 this this DET fnp-9165 114 32 rare rare ADJ fnp-9165 114 33 entity entity NOUN fnp-9165 114 34 . . PUNCT fnp-9165 114 35     SPACE fnp-9165 115 1 abstract abstract ADJ fnp-9165 115 2 12 12 NUM fnp-9165 115 3 free free ADJ fnp-9165 115 4 neuropathol neuropathol NOUN fnp-9165 115 5 6:23:16 6:23:16 NUM fnp-9165 115 6 neuropathological neuropathological ADJ fnp-9165 115 7 correlates correlate VERB fnp-9165 115 8 of of ADP fnp-9165 115 9 serum serum NOUN fnp-9165 115 10 biomarkers biomarker NOUN fnp-9165 115 11 during during ADP fnp-9165 115 12 the the DET fnp-9165 115 13 dying die VERB fnp-9165 115 14 process process NOUN fnp-9165 115 15 in in ADP fnp-9165 115 16 humans human NOUN fnp-9165 115 17 chloe chloe PROPN fnp-9165 115 18 p. p. PROPN fnp-9165 115 19 allen1 allen1 PROPN fnp-9165 115 20 , , PUNCT fnp-9165 115 21 catie catie PROPN fnp-9165 115 22 n. n. PROPN fnp-9165 115 23 futhey2 futhey2 PROPN fnp-9165 115 24 , , PUNCT fnp-9165 115 25 aditya aditya PROPN fnp-9165 115 26 swaro3 swaro3 PROPN fnp-9165 115 27 , , PUNCT fnp-9165 115 28 jordan jordan PROPN fnp-9165 115 29 d. d. PROPN fnp-9165 115 30 bird1 bird1 PROPN fnp-9165 115 31 , , PUNCT fnp-9165 115 32 sophie sophie PROPN fnp-9165 115 33 stukas4 stukas4 PROPN fnp-9165 115 34 , , PUNCT fnp-9165 115 35 mark mark PROPN fnp-9165 115 36 s. s. PROPN fnp-9165 115 37 cembrowski3–6 cembrowski3–6 PROPN fnp-9165 115 38 , , PUNCT fnp-9165 115 39 cheryl cheryl PROPN fnp-9165 115 40 l. l. PROPN fnp-9165 115 41 wellington4,5,8 wellington4,5,8 PROPN fnp-9165 115 42 , , PUNCT fnp-9165 115 43 mypinder mypinder NOUN fnp-9165 115 44 s. s. PROPN fnp-9165 115 45 sekhon1,4,8 sekhon1,4,8 PROPN fnp-9165 115 46 , , PUNCT fnp-9165 115 47 veronica veronica PROPN fnp-9165 115 48 hirsch‑reinshagen7,8 hirsch‑reinshagen7,8 PROPN fnp-9165 115 49 division division NOUN fnp-9165 115 50 of of ADP fnp-9165 115 51 critical critical ADJ fnp-9165 115 52 care care NOUN fnp-9165 115 53 medicine medicine NOUN fnp-9165 115 54 , , PUNCT fnp-9165 115 55 department department NOUN fnp-9165 115 56 of of ADP fnp-9165 115 57 medicine medicine NOUN fnp-9165 115 58 , , PUNCT fnp-9165 115 59 vancouver vancouver PROPN fnp-9165 115 60 general general PROPN fnp-9165 115 61 hospital hospital PROPN fnp-9165 115 62 and and CCONJ fnp-9165 115 63 university university PROPN fnp-9165 115 64 of of ADP fnp-9165 115 65 british british PROPN fnp-9165 115 66 columbia columbia PROPN fnp-9165 115 67 , , PUNCT fnp-9165 115 68 vancouver vancouver PROPN fnp-9165 115 69 , , PUNCT fnp-9165 115 70 canada canada PROPN fnp-9165 115 71 md md PROPN fnp-9165 115 72 / / SYM fnp-9165 115 73 phd phd NOUN fnp-9165 115 74 program program NOUN fnp-9165 115 75 , , PUNCT fnp-9165 115 76 university university NOUN fnp-9165 115 77 of of ADP fnp-9165 115 78 british british PROPN fnp-9165 115 79 columbia columbia PROPN fnp-9165 115 80 , , PUNCT fnp-9165 115 81 vancouver vancouver PROPN fnp-9165 115 82 , , PUNCT fnp-9165 115 83 canada canada PROPN fnp-9165 115 84 department department PROPN fnp-9165 115 85 of of ADP fnp-9165 115 86 cellular cellular ADJ fnp-9165 115 87 and and CCONJ fnp-9165 115 88 physiological physiological ADJ fnp-9165 115 89 sciences science NOUN fnp-9165 115 90 , , PUNCT fnp-9165 115 91 life life NOUN fnp-9165 115 92 sciences sciences PROPN fnp-9165 115 93 institute institute PROPN fnp-9165 115 94 , , PUNCT fnp-9165 115 95 university university PROPN fnp-9165 115 96 of of ADP fnp-9165 115 97 british british PROPN fnp-9165 115 98 columbia columbia PROPN fnp-9165 115 99 , , PUNCT fnp-9165 115 100 vancouver vancouver PROPN fnp-9165 115 101 , , PUNCT fnp-9165 115 102 canada canada PROPN fnp-9165 115 103 djavad djavad PROPN fnp-9165 115 104 mowafaghian mowafaghian PROPN fnp-9165 115 105 centre centre PROPN fnp-9165 115 106 for for ADP fnp-9165 115 107 brain brain NOUN fnp-9165 115 108 health health NOUN fnp-9165 115 109 , , PUNCT fnp-9165 115 110 department department NOUN fnp-9165 115 111 of of ADP fnp-9165 115 112 pathology pathology PROPN fnp-9165 115 113 and and CCONJ fnp-9165 115 114 laboratory laboratory NOUN fnp-9165 115 115 medicine medicine NOUN fnp-9165 115 116 , , PUNCT fnp-9165 115 117 faculty faculty NOUN fnp-9165 115 118 of of ADP fnp-9165 115 119 medicine medicine NOUN fnp-9165 115 120 , , PUNCT fnp-9165 115 121 university university NOUN fnp-9165 115 122 of of ADP fnp-9165 115 123 british british PROPN fnp-9165 115 124 columbia columbia PROPN fnp-9165 115 125 , , PUNCT fnp-9165 115 126 vancouver vancouver PROPN fnp-9165 115 127 , , PUNCT fnp-9165 115 128 canada canada PROPN fnp-9165 115 129 school school PROPN fnp-9165 115 130 of of ADP fnp-9165 115 131 biomedical biomedical ADJ fnp-9165 115 132 engineering engineering NOUN fnp-9165 115 133 , , PUNCT fnp-9165 115 134 university university NOUN fnp-9165 115 135 of of ADP fnp-9165 115 136 british british PROPN fnp-9165 115 137 columbia columbia PROPN fnp-9165 115 138 , , PUNCT fnp-9165 115 139 vancouver vancouver PROPN fnp-9165 115 140 , , PUNCT fnp-9165 115 141 canada canada PROPN fnp-9165 115 142 department department PROPN fnp-9165 115 143 of of ADP fnp-9165 115 144 mathematics mathematics PROPN fnp-9165 115 145 , , PUNCT fnp-9165 115 146 university university PROPN fnp-9165 115 147 of of ADP fnp-9165 115 148 british british PROPN fnp-9165 115 149 columbia columbia PROPN fnp-9165 115 150 , , PUNCT fnp-9165 115 151 vancouver vancouver PROPN fnp-9165 115 152 , , PUNCT fnp-9165 115 153 canada canada PROPN fnp-9165 115 154 division division NOUN fnp-9165 115 155 of of ADP fnp-9165 115 156 neuropathology neuropathology NOUN fnp-9165 115 157 , , PUNCT fnp-9165 115 158 department department NOUN fnp-9165 115 159 of of ADP fnp-9165 115 160 pathology pathology PROPN fnp-9165 115 161 and and CCONJ fnp-9165 115 162 laboratory laboratory NOUN fnp-9165 115 163 medicine medicine NOUN fnp-9165 115 164 ; ; PUNCT fnp-9165 115 165 general general ADJ fnp-9165 115 166 hospital hospital NOUN fnp-9165 115 167 and and CCONJ fnp-9165 115 168 university university PROPN fnp-9165 115 169 of of ADP fnp-9165 115 170 british british PROPN fnp-9165 115 171 columbia columbia PROPN fnp-9165 115 172 , , PUNCT fnp-9165 115 173 vancouver vancouver PROPN fnp-9165 115 174 , , PUNCT fnp-9165 115 175 canada canada PROPN fnp-9165 115 176 international international ADJ fnp-9165 115 177 collaborations collaboration NOUN fnp-9165 115 178 on on ADP fnp-9165 115 179 repair repair NOUN fnp-9165 115 180 discoveries discovery NOUN fnp-9165 115 181 , , PUNCT fnp-9165 115 182 university university NOUN fnp-9165 115 183 of of ADP fnp-9165 115 184 british british PROPN fnp-9165 115 185 columbia columbia PROPN fnp-9165 115 186 , , PUNCT fnp-9165 115 187 vancouver vancouver PROPN fnp-9165 115 188 , , PUNCT fnp-9165 115 189 canada canada PROPN fnp-9165 115 190 neurocritical neurocritical ADJ fnp-9165 115 191 patients patient NOUN fnp-9165 115 192 ( ( PUNCT fnp-9165 115 193 ncps ncps PROPN fnp-9165 115 194 ) ) PUNCT fnp-9165 115 195 admitted admit VERB fnp-9165 115 196 to to ADP fnp-9165 115 197 the the DET fnp-9165 115 198 intensive intensive ADJ fnp-9165 115 199 care care NOUN fnp-9165 115 200 unit unit NOUN fnp-9165 115 201 ( ( PUNCT fnp-9165 115 202 icu icu PROPN fnp-9165 115 203 ) ) PUNCT fnp-9165 115 204 have have VERB fnp-9165 115 205 severe severe ADJ fnp-9165 115 206 neurological neurological ADJ fnp-9165 115 207 damage damage NOUN fnp-9165 115 208 stemming stem VERB fnp-9165 115 209 from from ADP fnp-9165 115 210 diverse diverse ADJ fnp-9165 115 211 causes cause NOUN fnp-9165 115 212 including include VERB fnp-9165 115 213 hypoxic hypoxic ADV fnp-9165 115 214 ischemic ischemic ADJ fnp-9165 115 215 brain brain NOUN fnp-9165 115 216 injury injury NOUN fnp-9165 115 217 ( ( PUNCT fnp-9165 115 218 hibi hibi PROPN fnp-9165 115 219 ) ) PUNCT fnp-9165 115 220 , , PUNCT fnp-9165 115 221 intracranial intracranial ADJ fnp-9165 115 222 hemorrhage hemorrhage NOUN fnp-9165 115 223 ( ( PUNCT fnp-9165 115 224 ich ich NOUN fnp-9165 115 225 ) ) PUNCT fnp-9165 115 226 , , PUNCT fnp-9165 115 227 and and CCONJ fnp-9165 115 228 traumatic traumatic ADJ fnp-9165 115 229 brain brain NOUN fnp-9165 115 230 injury injury NOUN fnp-9165 115 231 ( ( PUNCT fnp-9165 115 232 tbi tbi NOUN fnp-9165 115 233 ) ) PUNCT fnp-9165 115 234 , , PUNCT fnp-9165 115 235 among among ADP fnp-9165 115 236 others other NOUN fnp-9165 115 237 . . PUNCT fnp-9165 116 1 recently recently ADV fnp-9165 116 2 , , PUNCT fnp-9165 116 3 blood blood NOUN fnp-9165 116 4 - - PUNCT fnp-9165 116 5 based base VERB fnp-9165 116 6 neurologic neurologic ADJ fnp-9165 116 7 biomarkers biomarker NOUN fnp-9165 116 8 have have AUX fnp-9165 116 9 emerged emerge VERB fnp-9165 116 10 as as ADP fnp-9165 116 11 a a DET fnp-9165 116 12 promising promising ADJ fnp-9165 116 13 tool tool NOUN fnp-9165 116 14 for for ADP fnp-9165 116 15 prognostication prognostication NOUN fnp-9165 116 16 , , PUNCT fnp-9165 116 17 however however ADV fnp-9165 116 18 , , PUNCT fnp-9165 116 19 their their PRON fnp-9165 116 20 utility utility NOUN fnp-9165 116 21 for for ADP fnp-9165 116 22 the the DET fnp-9165 116 23 diagnosis diagnosis NOUN fnp-9165 116 24 of of ADP fnp-9165 116 25 tissue tissue NOUN fnp-9165 116 26 injury injury NOUN fnp-9165 116 27 severity severity NOUN fnp-9165 116 28 and and CCONJ fnp-9165 116 29 the the DET fnp-9165 116 30 insights insight NOUN fnp-9165 116 31 they they PRON fnp-9165 116 32 provide provide VERB fnp-9165 116 33 into into ADP fnp-9165 116 34 the the DET fnp-9165 116 35 pathophysiology pathophysiology NOUN fnp-9165 116 36 of of ADP fnp-9165 116 37 this this DET fnp-9165 116 38 brain brain NOUN fnp-9165 116 39 injury injury NOUN fnp-9165 116 40 are be AUX fnp-9165 116 41 limited limited ADJ fnp-9165 116 42 . . PUNCT fnp-9165 117 1 we we PRON fnp-9165 117 2 aimed aim VERB fnp-9165 117 3 to to PART fnp-9165 117 4 investigate investigate VERB fnp-9165 117 5 the the DET fnp-9165 117 6 relationship relationship NOUN fnp-9165 117 7 of of ADP fnp-9165 117 8 120 120 NUM fnp-9165 117 9 blood blood NOUN fnp-9165 117 10 - - PUNCT fnp-9165 117 11 based base VERB fnp-9165 117 12 systemic systemic ADJ fnp-9165 117 13 and and CCONJ fnp-9165 117 14 neurologic neurologic ADJ fnp-9165 117 15 biomarkers biomarker NOUN fnp-9165 117 16 prior prior ADV fnp-9165 117 17 to to ADP fnp-9165 117 18 the the DET fnp-9165 117 19 withdrawal withdrawal NOUN fnp-9165 117 20 of of ADP fnp-9165 117 21 life life NOUN fnp-9165 117 22 - - PUNCT fnp-9165 117 23 sustaining sustain VERB fnp-9165 117 24 therapies therapy NOUN fnp-9165 117 25 ( ( PUNCT fnp-9165 117 26 wlst wlst NOUN fnp-9165 117 27 ) ) PUNCT fnp-9165 117 28 in in ADP fnp-9165 117 29 humans human NOUN fnp-9165 117 30 with with ADP fnp-9165 117 31 pre pre ADJ fnp-9165 117 32 - - ADJ fnp-9165 117 33 mortem mortem ADJ fnp-9165 117 34 clinical clinical ADJ fnp-9165 117 35 measures measure NOUN fnp-9165 117 36 and and CCONJ fnp-9165 117 37 post post ADJ fnp-9165 117 38 - - ADJ fnp-9165 117 39 mortem mortem ADJ fnp-9165 117 40 neuropathological neuropathological ADJ fnp-9165 117 41 features feature NOUN fnp-9165 117 42 in in ADP fnp-9165 117 43 different different ADJ fnp-9165 117 44 neurocritical neurocritical ADJ fnp-9165 117 45 conditions condition NOUN fnp-9165 117 46 . . PUNCT fnp-9165 118 1 clinical clinical ADJ fnp-9165 118 2 and and CCONJ fnp-9165 118 3 demographic demographic ADJ fnp-9165 118 4 data datum NOUN fnp-9165 118 5 , , PUNCT fnp-9165 118 6 along along ADP fnp-9165 118 7 with with ADP fnp-9165 118 8 arterial arterial ADJ fnp-9165 118 9 biospecimens biospecimen NOUN fnp-9165 118 10 , , PUNCT fnp-9165 118 11 were be AUX fnp-9165 118 12 obtained obtain VERB fnp-9165 118 13 from from ADP fnp-9165 118 14 twenty twenty NUM fnp-9165 118 15 - - PUNCT fnp-9165 118 16 nine nine NUM fnp-9165 118 17 patients patient NOUN fnp-9165 118 18 immediately immediately ADV fnp-9165 118 19 prior prior ADV fnp-9165 118 20 to to ADP fnp-9165 118 21 wlsm wlsm NOUN fnp-9165 118 22 with with ADP fnp-9165 118 23 subsequent subsequent ADJ fnp-9165 118 24 post post ADJ fnp-9165 118 25 - - ADJ fnp-9165 118 26 mortem mortem ADJ fnp-9165 118 27 neuropathological neuropathological ADJ fnp-9165 118 28 evaluation evaluation NOUN fnp-9165 118 29 . . PUNCT fnp-9165 119 1 proteomic proteomic ADJ fnp-9165 119 2 analysis analysis NOUN fnp-9165 119 3 of of ADP fnp-9165 119 4 plasma plasma NOUN fnp-9165 119 5 samples sample NOUN fnp-9165 119 6 was be AUX fnp-9165 119 7 performed perform VERB fnp-9165 119 8 using use VERB fnp-9165 119 9 the the DET fnp-9165 119 10 argo argo PROPN fnp-9165 119 11 ht ht PROPN fnp-9165 119 12 platform platform NOUN fnp-9165 119 13 . . PUNCT fnp-9165 120 1 a a DET fnp-9165 120 2 standard standard ADJ fnp-9165 120 3 neuropathological neuropathological ADJ fnp-9165 120 4 evaluation evaluation NOUN fnp-9165 120 5 was be AUX fnp-9165 120 6 performed perform VERB fnp-9165 120 7 followed follow VERB fnp-9165 120 8 by by ADP fnp-9165 120 9 exploratory exploratory ADJ fnp-9165 120 10 and and CCONJ fnp-9165 120 11 advanced advanced ADJ fnp-9165 120 12 data datum NOUN fnp-9165 120 13 analyses analysis NOUN fnp-9165 120 14 . . PUNCT fnp-9165 121 1 ten ten NUM fnp-9165 121 2 brain brain NOUN fnp-9165 121 3 - - PUNCT fnp-9165 121 4 enhanced enhance VERB fnp-9165 121 5 markers marker NOUN fnp-9165 121 6 were be AUX fnp-9165 121 7 identified identify VERB fnp-9165 121 8 that that PRON fnp-9165 121 9 exhibited exhibit VERB fnp-9165 121 10 significant significant ADJ fnp-9165 121 11 positive positive ADJ fnp-9165 121 12 associations association NOUN fnp-9165 121 13 with with ADP fnp-9165 121 14 neuropathological neuropathological ADJ fnp-9165 121 15 features feature NOUN fnp-9165 121 16 , , PUNCT fnp-9165 121 17 most most ADV fnp-9165 121 18 prominently prominently ADV fnp-9165 121 19 selective selective ADJ fnp-9165 121 20 neuronal neuronal ADJ fnp-9165 121 21 death death NOUN fnp-9165 121 22 ( ( PUNCT fnp-9165 121 23 snd snd PROPN fnp-9165 121 24 ) ) PUNCT fnp-9165 121 25 and and CCONJ fnp-9165 121 26 reactive reactive ADJ fnp-9165 121 27 gliosis gliosis NOUN fnp-9165 121 28 : : PUNCT fnp-9165 121 29 eno2 eno2 PROPN fnp-9165 121 30 , , PUNCT fnp-9165 121 31 mapt mapt NOUN fnp-9165 121 32 , , PUNCT fnp-9165 121 33 nefh nefh NOUN fnp-9165 121 34 , , PUNCT fnp-9165 121 35 nefl nefl NOUN fnp-9165 121 36 , , PUNCT fnp-9165 121 37 nrgn nrgn NOUN fnp-9165 121 38 , , PUNCT fnp-9165 121 39 ptau-217 ptau-217 NOUN fnp-9165 121 40 , , PUNCT fnp-9165 121 41 snap25 snap25 NOUN fnp-9165 121 42 , , PUNCT fnp-9165 121 43 sncb sncb NOUN fnp-9165 121 44 , , PUNCT fnp-9165 121 45 and and CCONJ fnp-9165 121 46 uchl1 uchl1 NOUN fnp-9165 121 47 . . PUNCT fnp-9165 122 1 notably notably ADV fnp-9165 122 2 , , PUNCT fnp-9165 122 3 these these DET fnp-9165 122 4 associations association NOUN fnp-9165 122 5 were be AUX fnp-9165 122 6 also also ADV fnp-9165 122 7 successful successful ADJ fnp-9165 122 8 in in ADP fnp-9165 122 9 striating striate VERB fnp-9165 122 10 patients patient NOUN fnp-9165 122 11 by by ADP fnp-9165 122 12 their their PRON fnp-9165 122 13 respective respective ADJ fnp-9165 122 14 cause cause NOUN fnp-9165 122 15 of of ADP fnp-9165 122 16 injury injury NOUN fnp-9165 122 17 . . PUNCT fnp-9165 123 1 no no DET fnp-9165 123 2 significant significant ADJ fnp-9165 123 3 correlations correlation NOUN fnp-9165 123 4 were be AUX fnp-9165 123 5 present present ADJ fnp-9165 123 6 with with ADP fnp-9165 123 7 chronic chronic ADJ fnp-9165 123 8 vascular vascular NOUN fnp-9165 123 9 , , PUNCT fnp-9165 123 10 neurodegenerative neurodegenerative ADJ fnp-9165 123 11 , , PUNCT fnp-9165 123 12 or or CCONJ fnp-9165 123 13 inflammatory inflammatory ADJ fnp-9165 123 14 neuropathology neuropathology NOUN fnp-9165 123 15 . . PUNCT fnp-9165 124 1 collectively collectively ADV fnp-9165 124 2 , , PUNCT fnp-9165 124 3 these these DET fnp-9165 124 4 results result NOUN fnp-9165 124 5 provide provide VERB fnp-9165 124 6 neuropathological neuropathological ADJ fnp-9165 124 7 demonstration demonstration NOUN fnp-9165 124 8 of of ADP fnp-9165 124 9 the the DET fnp-9165 124 10 brain brain NOUN fnp-9165 124 11 tissue tissue NOUN fnp-9165 124 12 changes change NOUN fnp-9165 124 13 in in ADP fnp-9165 124 14 neurocritically neurocritically ADV fnp-9165 124 15 - - PUNCT fnp-9165 124 16 ill ill ADJ fnp-9165 124 17 patients patient NOUN fnp-9165 124 18 and and CCONJ fnp-9165 124 19 their their PRON fnp-9165 124 20 immediate immediate ADJ fnp-9165 124 21 correlation correlation NOUN fnp-9165 124 22 with with ADP fnp-9165 124 23 serum serum NOUN fnp-9165 124 24 biomarkers biomarker NOUN fnp-9165 124 25 . . PUNCT fnp-9165 125 1 they they PRON fnp-9165 125 2 also also ADV fnp-9165 125 3 demonstrate demonstrate VERB fnp-9165 125 4 that that SCONJ fnp-9165 125 5 select select ADJ fnp-9165 125 6 brain brain NOUN fnp-9165 125 7 - - PUNCT fnp-9165 125 8 enhanced enhance VERB fnp-9165 125 9 biomarkers biomarker NOUN fnp-9165 125 10 likely likely ADV fnp-9165 125 11 possess possess VERB fnp-9165 125 12 diagnostic diagnostic ADJ fnp-9165 125 13 and and CCONJ fnp-9165 125 14 prognostic prognostic ADJ fnp-9165 125 15 utility utility NOUN fnp-9165 125 16 . . PUNCT fnp-9165 125 17     SPACE fnp-9165 126 1 abstract abstract ADJ fnp-9165 126 2 13 13 NUM fnp-9165 126 3 free free ADJ fnp-9165 126 4 neuropathol neuropathol NOUN fnp-9165 126 5 6:23:18 6:23:18 NUM fnp-9165 126 6 brainstem brainstem NOUN fnp-9165 126 7 cap cap NOUN fnp-9165 126 8 dysplasias dysplasias PROPN fnp-9165 126 9 : : PUNCT fnp-9165 126 10 pathology pathology NOUN fnp-9165 126 11 and and CCONJ fnp-9165 126 12 novel novel ADJ fnp-9165 126 13 descriptions description NOUN fnp-9165 126 14 stephanie stephanie PROPN fnp-9165 126 15 r. r. PROPN fnp-9165 126 16 beldick1 beldick1 PROPN fnp-9165 126 17 , , PUNCT fnp-9165 126 18 andrew andrew PROPN fnp-9165 126 19 gao2,3 gao2,3 PROPN fnp-9165 126 20 , , PUNCT fnp-9165 126 21 yael yael PROPN fnp-9165 126 22 fisher4 fisher4 PROPN fnp-9165 126 23 , , PUNCT fnp-9165 126 24 patrick patrick PROPN fnp-9165 126 25 shannon2,4 shannon2,4 PROPN fnp-9165 126 26 department department PROPN fnp-9165 126 27 of of ADP fnp-9165 126 28 laboratory laboratory NOUN fnp-9165 126 29 medicine medicine NOUN fnp-9165 126 30 and and CCONJ fnp-9165 126 31 pathology pathology NOUN fnp-9165 126 32 , , PUNCT fnp-9165 126 33 western western ADJ fnp-9165 126 34 university university PROPN fnp-9165 126 35 , , PUNCT fnp-9165 126 36 london london PROPN fnp-9165 126 37 , , PUNCT fnp-9165 126 38 canada canada PROPN fnp-9165 126 39 laboratory laboratory NOUN fnp-9165 126 40 medicine medicine NOUN fnp-9165 126 41 and and CCONJ fnp-9165 126 42 pathobiology pathobiology NOUN fnp-9165 126 43 , , PUNCT fnp-9165 126 44 university university PROPN fnp-9165 126 45 of of ADP fnp-9165 126 46 toronto toronto PROPN fnp-9165 126 47 , , PUNCT fnp-9165 126 48 toronto toronto PROPN fnp-9165 126 49 , , PUNCT fnp-9165 126 50 canada canada PROPN fnp-9165 126 51 university university PROPN fnp-9165 126 52 health health NOUN fnp-9165 126 53 network network PROPN fnp-9165 126 54 , , PUNCT fnp-9165 126 55 toronto toronto PROPN fnp-9165 126 56 , , PUNCT fnp-9165 126 57 canada canada PROPN fnp-9165 126 58 mount mount PROPN fnp-9165 126 59 sinai sinai PROPN fnp-9165 126 60 hospital hospital PROPN fnp-9165 126 61 , , PUNCT fnp-9165 126 62 toronto toronto PROPN fnp-9165 126 63 , , PUNCT fnp-9165 126 64 canada canada PROPN fnp-9165 126 65 brainstem brainstem NOUN fnp-9165 126 66 cap cap NOUN fnp-9165 126 67 dysplasias dysplasia NOUN fnp-9165 126 68 are be AUX fnp-9165 126 69 characterized characterize VERB fnp-9165 126 70 by by ADP fnp-9165 126 71 heterotopic heterotopic ADJ fnp-9165 126 72 axonal axonal ADJ fnp-9165 126 73 tracts tract NOUN fnp-9165 126 74 coursing course VERB fnp-9165 126 75 peripherally peripherally ADV fnp-9165 126 76 in in ADP fnp-9165 126 77 the the DET fnp-9165 126 78 brainstem brainstem NOUN fnp-9165 126 79 , , PUNCT fnp-9165 126 80 identified identify VERB fnp-9165 126 81 by by ADP fnp-9165 126 82 magnetic magnetic ADJ fnp-9165 126 83 resonance resonance NOUN fnp-9165 126 84 imaging imaging NOUN fnp-9165 126 85 . . PUNCT fnp-9165 127 1 however however ADV fnp-9165 127 2 , , PUNCT fnp-9165 127 3 there there PRON fnp-9165 127 4 is be VERB fnp-9165 127 5 a a DET fnp-9165 127 6 paucity paucity NOUN fnp-9165 127 7 of of ADP fnp-9165 127 8 neuropathological neuropathological ADJ fnp-9165 127 9 descriptions description NOUN fnp-9165 127 10 of of ADP fnp-9165 127 11 cap cap NOUN fnp-9165 127 12 dysplasias dysplasias PROPN fnp-9165 127 13 . . PUNCT fnp-9165 128 1 we we PRON fnp-9165 128 2 therefore therefore ADV fnp-9165 128 3 aimed aim VERB fnp-9165 128 4 to to PART fnp-9165 128 5 review review VERB fnp-9165 128 6 the the DET fnp-9165 128 7 histopathology histopathology NOUN fnp-9165 128 8 and and CCONJ fnp-9165 128 9 expand expand VERB fnp-9165 128 10 the the DET fnp-9165 128 11 morphological morphological ADJ fnp-9165 128 12 spectrum spectrum NOUN fnp-9165 128 13 of of ADP fnp-9165 128 14 cap cap NOUN fnp-9165 128 15 dysplasias dysplasias PROPN fnp-9165 128 16 . . PUNCT fnp-9165 129 1 three three NUM fnp-9165 129 2 forms form NOUN fnp-9165 129 3 are be AUX fnp-9165 129 4 described describe VERB fnp-9165 129 5 , , PUNCT fnp-9165 129 6 including include VERB fnp-9165 129 7 pontine pontine ADJ fnp-9165 129 8 tegmental tegmental ADJ fnp-9165 129 9 cap cap NOUN fnp-9165 129 10 dysplasia dysplasia NOUN fnp-9165 129 11 ( ( PUNCT fnp-9165 129 12 ptcd ptcd NOUN fnp-9165 129 13 ) ) PUNCT fnp-9165 129 14 , , PUNCT fnp-9165 129 15 medullary medullary ADJ fnp-9165 129 16 tegmental tegmental ADJ fnp-9165 129 17 cap cap NOUN fnp-9165 129 18 dysplasia dysplasia NOUN fnp-9165 129 19 ( ( PUNCT fnp-9165 129 20 mtcd mtcd NOUN fnp-9165 129 21 ) ) PUNCT fnp-9165 129 22 , , PUNCT fnp-9165 129 23 and and CCONJ fnp-9165 129 24 anterior anterior ADJ fnp-9165 129 25 mesencephalic mesencephalic ADJ fnp-9165 129 26 cap cap NOUN fnp-9165 129 27 dysplasia dysplasia NOUN fnp-9165 129 28 ( ( PUNCT fnp-9165 129 29 amcd amcd ADJ fnp-9165 129 30 ; ; PUNCT fnp-9165 129 31 a a DET fnp-9165 129 32 component component NOUN fnp-9165 129 33 of of ADP fnp-9165 129 34 the the DET fnp-9165 129 35 joubert joubert PROPN fnp-9165 129 36 syndrome syndrome PROPN fnp-9165 129 37 ) ) PUNCT fnp-9165 129 38 . . PUNCT fnp-9165 130 1 we we PRON fnp-9165 130 2 describe describe VERB fnp-9165 130 3 a a DET fnp-9165 130 4 series series NOUN fnp-9165 130 5 of of ADP fnp-9165 130 6 seven seven NUM fnp-9165 130 7 brainstem brainstem NOUN fnp-9165 130 8 dysplasias dysplasia VERB fnp-9165 130 9 with with ADP fnp-9165 130 10 " " PUNCT fnp-9165 130 11 cap cap NOUN fnp-9165 130 12 " " PUNCT fnp-9165 130 13 features feature NOUN fnp-9165 130 14 from from ADP fnp-9165 130 15 our our PRON fnp-9165 130 16 autopsy autopsy ADJ fnp-9165 130 17 practice practice NOUN fnp-9165 130 18 : : PUNCT fnp-9165 130 19 two two NUM fnp-9165 130 20 ptcd ptcd NOUN fnp-9165 130 21 , , PUNCT fnp-9165 130 22 one one NUM fnp-9165 130 23 mtcd mtcd NOUN fnp-9165 130 24 , , PUNCT fnp-9165 130 25 two two NUM fnp-9165 130 26 amcd amcd ADJ fnp-9165 130 27 , , PUNCT fnp-9165 130 28 and and CCONJ fnp-9165 130 29 two two NUM fnp-9165 130 30 undescribed undescribed ADJ fnp-9165 130 31 forms form NOUN fnp-9165 130 32 . . PUNCT fnp-9165 131 1 both both DET fnp-9165 131 2 ptcd ptcd NOUN fnp-9165 131 3 cases case NOUN fnp-9165 131 4 demonstrated demonstrate VERB fnp-9165 131 5 hypoplasia hypoplasia NOUN fnp-9165 131 6 of of ADP fnp-9165 131 7 rhombic rhombic ADJ fnp-9165 131 8 lip lip NOUN fnp-9165 131 9 derivatives derivative NOUN fnp-9165 131 10 and and CCONJ fnp-9165 131 11 a a DET fnp-9165 131 12 dorsal dorsal NOUN fnp-9165 131 13 pontine pontine NOUN fnp-9165 131 14 tegmental tegmental ADJ fnp-9165 131 15 tract tract NOUN fnp-9165 131 16 . . PUNCT fnp-9165 132 1 the the DET fnp-9165 132 2 mtcd mtcd NOUN fnp-9165 132 3 case case NOUN fnp-9165 132 4 demonstrated demonstrate VERB fnp-9165 132 5 hypoplastic hypoplastic ADJ fnp-9165 132 6 rhombic rhombic ADJ fnp-9165 132 7 lip lip NOUN fnp-9165 132 8 derivatives derivative NOUN fnp-9165 132 9 , , PUNCT fnp-9165 132 10 large large ADJ fnp-9165 132 11 axonal axonal ADJ fnp-9165 132 12 tracts tract NOUN fnp-9165 132 13 in in ADP fnp-9165 132 14 the the DET fnp-9165 132 15 medullary medullary ADJ fnp-9165 132 16 fourth fourth ADJ fnp-9165 132 17 ventricle ventricle NOUN fnp-9165 132 18 and and CCONJ fnp-9165 132 19 coursing coursing NOUN fnp-9165 132 20 along along ADP fnp-9165 132 21 the the DET fnp-9165 132 22 ventrolateral ventrolateral ADJ fnp-9165 132 23 medulla medulla NOUN fnp-9165 132 24 , , PUNCT fnp-9165 132 25 post post ADJ fnp-9165 132 26 - - ADJ fnp-9165 132 27 necrotic necrotic ADJ fnp-9165 132 28 tegmental tegmental ADJ fnp-9165 132 29 calcifications calcification NOUN fnp-9165 132 30 , , PUNCT fnp-9165 132 31 and and CCONJ fnp-9165 132 32 spinal spinal ADJ fnp-9165 132 33 cord cord NOUN fnp-9165 132 34 anomalies anomaly NOUN fnp-9165 132 35 . . PUNCT fnp-9165 133 1 the the DET fnp-9165 133 2 two two NUM fnp-9165 133 3 amcd amcd ADJ fnp-9165 133 4 cases case NOUN fnp-9165 133 5 demonstrated demonstrate VERB fnp-9165 133 6 joubert joubert PROPN fnp-9165 133 7 syndrome syndrome PROPN fnp-9165 133 8 features feature VERB fnp-9165 133 9 with with ADP fnp-9165 133 10 axonal axonal ADJ fnp-9165 133 11 bundles bundle NOUN fnp-9165 133 12 crossing cross VERB fnp-9165 133 13 the the DET fnp-9165 133 14 interpeduncular interpeduncular ADJ fnp-9165 133 15 fossa fossa NOUN fnp-9165 133 16 as as ADP fnp-9165 133 17 leptomeningeal leptomeningeal NOUN fnp-9165 133 18 heterotopias heterotopia NOUN fnp-9165 133 19 . . PUNCT fnp-9165 134 1 the the DET fnp-9165 134 2 two two NUM fnp-9165 134 3 additional additional ADJ fnp-9165 134 4 cases case NOUN fnp-9165 134 5 of of ADP fnp-9165 134 6 undescribed undescribed ADJ fnp-9165 134 7 " " PUNCT fnp-9165 134 8 cap cap NOUN fnp-9165 134 9 " " PUNCT fnp-9165 134 10 forms form NOUN fnp-9165 134 11 have have VERB fnp-9165 134 12 a a DET fnp-9165 134 13 prominent prominent ADJ fnp-9165 134 14 tectal tectal ADJ fnp-9165 134 15 cap cap NOUN fnp-9165 134 16 . . PUNCT fnp-9165 135 1 in in ADP fnp-9165 135 2 one one NUM fnp-9165 135 3 case case NOUN fnp-9165 135 4 , , PUNCT fnp-9165 135 5 this this PRON fnp-9165 135 6 is be AUX fnp-9165 135 7 formed form VERB fnp-9165 135 8 by by ADP fnp-9165 135 9 aberrancy aberrancy NOUN fnp-9165 135 10 in in ADP fnp-9165 135 11 the the DET fnp-9165 135 12 pathway pathway NOUN fnp-9165 135 13 of of ADP fnp-9165 135 14 the the DET fnp-9165 135 15 inferior inferior ADJ fnp-9165 135 16 colliculi colliculi NOUN fnp-9165 135 17 brachia brachia NOUN fnp-9165 135 18 , , PUNCT fnp-9165 135 19 and and CCONJ fnp-9165 135 20 in in ADP fnp-9165 135 21 the the DET fnp-9165 135 22 other other ADJ fnp-9165 135 23 it it PRON fnp-9165 135 24 is be AUX fnp-9165 135 25 formed form VERB fnp-9165 135 26 by by ADP fnp-9165 135 27 incomplete incomplete ADJ fnp-9165 135 28 duplication duplication NOUN fnp-9165 135 29 and and CCONJ fnp-9165 135 30 fusion fusion NOUN fnp-9165 135 31 of of ADP fnp-9165 135 32 midbrain midbrain NOUN fnp-9165 135 33 with with ADP fnp-9165 135 34 cerebellar cerebellar ADJ fnp-9165 135 35 elements element NOUN fnp-9165 135 36 , , PUNCT fnp-9165 135 37 and and CCONJ fnp-9165 135 38 heterotopic heterotopic VERB fnp-9165 135 39 dorsal dorsal NOUN fnp-9165 135 40 and and CCONJ fnp-9165 135 41 lateral lateral ADJ fnp-9165 135 42 medullary medullary ADJ fnp-9165 135 43 tracts tract NOUN fnp-9165 135 44 , , PUNCT fnp-9165 135 45 in in ADP fnp-9165 135 46 the the DET fnp-9165 135 47 context context NOUN fnp-9165 135 48 of of ADP fnp-9165 135 49 a a DET fnp-9165 135 50 complex complex ADJ fnp-9165 135 51 supratentorial supratentorial ADJ fnp-9165 135 52 malformation malformation NOUN fnp-9165 135 53 . . PUNCT fnp-9165 136 1 in in ADP fnp-9165 136 2 summary summary NOUN fnp-9165 136 3 , , PUNCT fnp-9165 136 4 " " PUNCT fnp-9165 136 5 cap cap NOUN fnp-9165 136 6 dysplasia dysplasia NOUN fnp-9165 136 7 " " PUNCT fnp-9165 136 8 should should AUX fnp-9165 136 9 be be AUX fnp-9165 136 10 considered consider VERB fnp-9165 136 11 a a DET fnp-9165 136 12 morphological morphological ADJ fnp-9165 136 13 descriptor descriptor NOUN fnp-9165 136 14 rather rather ADV fnp-9165 136 15 than than ADP fnp-9165 136 16 limited limit VERB fnp-9165 136 17 to to ADP fnp-9165 136 18 axonal axonal ADJ fnp-9165 136 19 pathology pathology NOUN fnp-9165 136 20 or or CCONJ fnp-9165 136 21 a a DET fnp-9165 136 22 particular particular ADJ fnp-9165 136 23 disease disease NOUN fnp-9165 136 24 entity entity NOUN fnp-9165 136 25 , , PUNCT fnp-9165 136 26 as as SCONJ fnp-9165 136 27 a a DET fnp-9165 136 28 diversity diversity NOUN fnp-9165 136 29 of of ADP fnp-9165 136 30 pathological pathological ADJ fnp-9165 136 31 developmental developmental ADJ fnp-9165 136 32 processes process NOUN fnp-9165 136 33 are be AUX fnp-9165 136 34 evident evident ADJ fnp-9165 136 35 . . PUNCT fnp-9165 136 36     SPACE fnp-9165 137 1 abstract abstract ADJ fnp-9165 137 2 14 14 NUM fnp-9165 137 3 free free ADJ fnp-9165 137 4 neuropathol neuropathol NOUN fnp-9165 137 5 6:23:19 6:23:19 NUM fnp-9165 137 6 keratan keratan ADJ fnp-9165 137 7 sulfate sulfate NOUN fnp-9165 137 8 proteoglycan proteoglycan NOUN fnp-9165 137 9 is be AUX fnp-9165 137 10 not not PART fnp-9165 137 11 expressed express VERB fnp-9165 137 12 in in ADP fnp-9165 137 13 the the DET fnp-9165 137 14 human human ADJ fnp-9165 137 15 fetal fetal ADJ fnp-9165 137 16 cerebellar cerebellar ADJ fnp-9165 137 17 system system NOUN fnp-9165 137 18 except except SCONJ fnp-9165 137 19 in in ADP fnp-9165 137 20 pontine pontine ADJ fnp-9165 137 21 nuclei nucleus NOUN fnp-9165 137 22 and and CCONJ fnp-9165 137 23 transitory transitory ADJ fnp-9165 137 24 vermal vermal ADJ fnp-9165 137 25 septa septum NOUN fnp-9165 137 26 ; ; PUNCT fnp-9165 137 27 not not PART fnp-9165 137 28 in in ADP fnp-9165 137 29 corticospinal corticospinal ADJ fnp-9165 137 30 fasciculi fasciculi PROPN fnp-9165 137 31 caudal caudal NOUN fnp-9165 137 32 to to ADP fnp-9165 137 33 internal internal ADJ fnp-9165 137 34 capsule capsule PROPN fnp-9165 137 35 harvey harvey PROPN fnp-9165 137 36 b. b. PROPN fnp-9165 137 37 sarnat1 sarnat1 PROPN fnp-9165 137 38 , , PUNCT fnp-9165 137 39 weiming weime VERB fnp-9165 137 40 yu2 yu2 PROPN fnp-9165 137 41 , , PUNCT fnp-9165 137 42 laura laura PROPN fnp-9165 137 43 flores flores PROPN fnp-9165 137 44 - - PUNCT fnp-9165 137 45 sarnat3 sarnat3 NOUN fnp-9165 137 46 departments department NOUN fnp-9165 137 47 of of ADP fnp-9165 137 48 paediatrics paediatric NOUN fnp-9165 137 49 , , PUNCT fnp-9165 137 50 pathology pathology NOUN fnp-9165 137 51 ( ( PUNCT fnp-9165 137 52 neuropathology neuropathology NOUN fnp-9165 137 53 ) ) PUNCT fnp-9165 137 54 , , PUNCT fnp-9165 137 55 clinical clinical ADJ fnp-9165 137 56 neurosciences neuroscience NOUN fnp-9165 137 57 , , PUNCT fnp-9165 137 58 university university NOUN fnp-9165 137 59 of of ADP fnp-9165 137 60 calgary calgary PROPN fnp-9165 137 61 ; ; PUNCT fnp-9165 137 62 alberta alberta PROPN fnp-9165 137 63 children children PROPN fnp-9165 137 64 ’s ’s PART fnp-9165 137 65 hospital hospital PROPN fnp-9165 137 66 research research PROPN fnp-9165 137 67 institute institute PROPN fnp-9165 137 68 ( ( PUNCT fnp-9165 137 69 owerko owerko PROPN fnp-9165 137 70 centre centre PROPN fnp-9165 137 71 ) ) PUNCT fnp-9165 137 72 , , PUNCT fnp-9165 137 73 calgary calgary PROPN fnp-9165 137 74 , , PUNCT fnp-9165 137 75 alberta alberta PROPN fnp-9165 137 76 , , PUNCT fnp-9165 137 77 canada canada PROPN fnp-9165 137 78 department department PROPN fnp-9165 137 79 of of ADP fnp-9165 137 80 pathology pathology PROPN fnp-9165 137 81 ( ( PUNCT fnp-9165 137 82 paediatric paediatric ADJ fnp-9165 137 83 anatomical anatomical ADJ fnp-9165 137 84 pathology pathology NOUN fnp-9165 137 85 ) ) PUNCT fnp-9165 137 86 , , PUNCT fnp-9165 137 87 university university NOUN fnp-9165 137 88 of of ADP fnp-9165 137 89 calgary calgary PROPN fnp-9165 137 90 and and CCONJ fnp-9165 137 91 alberta alberta PROPN fnp-9165 137 92 children children PROPN fnp-9165 137 93 ’s ’s PART fnp-9165 137 94 hospital hospital NOUN fnp-9165 137 95 , , PUNCT fnp-9165 137 96 calgary calgary PROPN fnp-9165 137 97 , , PUNCT fnp-9165 137 98 alberta alberta PROPN fnp-9165 137 99 , , PUNCT fnp-9165 137 100 canada canada PROPN fnp-9165 137 101 departments department NOUN fnp-9165 137 102 of of ADP fnp-9165 137 103 paediatrics paediatric NOUN fnp-9165 137 104 , , PUNCT fnp-9165 137 105 clinical clinical ADJ fnp-9165 137 106 neurosciences neuroscience NOUN fnp-9165 137 107 , , PUNCT fnp-9165 137 108 university university NOUN fnp-9165 137 109 of of ADP fnp-9165 137 110 calgary calgary PROPN fnp-9165 137 111 and and CCONJ fnp-9165 137 112 alberta alberta PROPN fnp-9165 137 113 children children PROPN fnp-9165 137 114 ’s ’s PART fnp-9165 137 115 hospital hospital PROPN fnp-9165 137 116 research research PROPN fnp-9165 137 117 institute institute PROPN fnp-9165 137 118 ( ( PUNCT fnp-9165 137 119 owerko owerko PROPN fnp-9165 137 120 centre centre PROPN fnp-9165 137 121 ) ) PUNCT fnp-9165 137 122 , , PUNCT fnp-9165 137 123 calgary calgary PROPN fnp-9165 137 124 , , PUNCT fnp-9165 137 125 alberta alberta PROPN fnp-9165 137 126 , , PUNCT fnp-9165 137 127 canada canada PROPN fnp-9165 137 128 we we PRON fnp-9165 137 129 determined determine VERB fnp-9165 137 130 spatial spatial ADJ fnp-9165 137 131 and and CCONJ fnp-9165 137 132 temporal temporal ADJ fnp-9165 137 133 expression expression NOUN fnp-9165 137 134 of of ADP fnp-9165 137 135 keratan keratan PROPN fnp-9165 137 136 sulfate sulfate NOUN fnp-9165 137 137 ( ( PUNCT fnp-9165 137 138 ks ks NOUN fnp-9165 137 139 ) ) PUNCT fnp-9165 137 140 proteoglycan proteoglycan NOUN fnp-9165 137 141 in in ADP fnp-9165 137 142 the the DET fnp-9165 137 143 cerebellar cerebellar ADJ fnp-9165 137 144 system system NOUN fnp-9165 137 145 , , PUNCT fnp-9165 137 146 dysgeneses dysgenese NOUN fnp-9165 137 147 and and CCONJ fnp-9165 137 148 in in ADP fnp-9165 137 149 white white ADJ fnp-9165 137 150 matter matter NOUN fnp-9165 137 151 fasciculi fasciculus NOUN fnp-9165 137 152 . . PUNCT fnp-9165 138 1 ks k NOUN fnp-9165 138 2 proteoglycan proteoglycan PROPN fnp-9165 138 3 is be AUX fnp-9165 138 4 an an DET fnp-9165 138 5 extracellular extracellular ADJ fnp-9165 138 6 matrix matrix NOUN fnp-9165 138 7 molecule molecule NOUN fnp-9165 138 8 secreted secrete VERB fnp-9165 138 9 by by ADP fnp-9165 138 10 astrocytes astrocyte NOUN fnp-9165 138 11 . . PUNCT fnp-9165 139 1 ks k NOUN fnp-9165 139 2 forms form VERB fnp-9165 139 3 an an DET fnp-9165 139 4 early early ADJ fnp-9165 139 5 template template NOUN fnp-9165 139 6 of of ADP fnp-9165 139 7 neuroblastic neuroblastic ADJ fnp-9165 139 8 migration migration NOUN fnp-9165 139 9 to to ADP fnp-9165 139 10 the the DET fnp-9165 139 11 cortical cortical ADJ fnp-9165 139 12 plate plate NOUN fnp-9165 139 13 and and CCONJ fnp-9165 139 14 some some DET fnp-9165 139 15 axonal axonal ADJ fnp-9165 139 16 fascicles fascicle NOUN fnp-9165 139 17 before before SCONJ fnp-9165 139 18 axons axon NOUN fnp-9165 139 19 enter enter VERB fnp-9165 139 20 . . PUNCT fnp-9165 140 1 ks ks PROPN fnp-9165 140 2 immunoreactivity immunoreactivity PROPN fnp-9165 140 3 was be AUX fnp-9165 140 4 studied study VERB fnp-9165 140 5 in in ADP fnp-9165 140 6 sections section NOUN fnp-9165 140 7 of of ADP fnp-9165 140 8 cerebellar cerebellar ADJ fnp-9165 140 9 cortex cortex NOUN fnp-9165 140 10 and and CCONJ fnp-9165 140 11 in in ADP fnp-9165 140 12 deep deep ADJ fnp-9165 140 13 cerebellar cerebellar ADJ fnp-9165 140 14 , , PUNCT fnp-9165 140 15 inferior inferior ADJ fnp-9165 140 16 olivary olivary NOUN fnp-9165 140 17 and and CCONJ fnp-9165 140 18 red red ADJ fnp-9165 140 19 nuclei nucleus NOUN fnp-9165 140 20 and and CCONJ fnp-9165 140 21 white white ADJ fnp-9165 140 22 matter matter NOUN fnp-9165 140 23 in in ADP fnp-9165 140 24 18 18 NUM fnp-9165 140 25 human human ADJ fnp-9165 140 26 fetuses fetus NOUN fnp-9165 140 27 14–41 14–41 NUM fnp-9165 140 28 weeks week NOUN fnp-9165 140 29 gestation gestation NOUN fnp-9165 140 30 at at ADP fnp-9165 140 31 autopsy autopsy ADJ fnp-9165 140 32 , , PUNCT fnp-9165 140 33 6 6 NUM fnp-9165 140 34 infants infant NOUN fnp-9165 140 35 to to ADP fnp-9165 140 36 2 2 NUM fnp-9165 140 37 years year NOUN fnp-9165 140 38 , , PUNCT fnp-9165 140 39 and and CCONJ fnp-9165 140 40 9 9 NUM fnp-9165 140 41 cerebellar cerebellar ADJ fnp-9165 140 42 dysgeneses dysgenese NOUN fnp-9165 140 43 . . PUNCT fnp-9165 141 1 synaptophysin synaptophysin NOUN fnp-9165 141 2 expression expression NOUN fnp-9165 141 3 was be AUX fnp-9165 141 4 compared compare VERB fnp-9165 141 5 . . PUNCT fnp-9165 142 1 dentate dentate VERB fnp-9165 142 2 , , PUNCT fnp-9165 142 3 inferior inferior ADJ fnp-9165 142 4 olivary olivary NOUN fnp-9165 142 5 and and CCONJ fnp-9165 142 6 red red ADJ fnp-9165 142 7 nuclei nucleus NOUN fnp-9165 142 8 are be AUX fnp-9165 142 9 nonreactive nonreactive ADJ fnp-9165 142 10 at at ADP fnp-9165 142 11 all all DET fnp-9165 142 12 ages age NOUN fnp-9165 142 13 , , PUNCT fnp-9165 142 14 but but CCONJ fnp-9165 142 15 pontine pontine ADJ fnp-9165 142 16 nuclei nucleus NOUN fnp-9165 142 17 are be AUX fnp-9165 142 18 positive positive ADJ fnp-9165 142 19 from from ADP fnp-9165 142 20 early early ADJ fnp-9165 142 21 2nd 2nd ADJ fnp-9165 142 22 trimester trimester NOUN fnp-9165 142 23 . . PUNCT fnp-9165 143 1 cerebellar cerebellar ADJ fnp-9165 143 2 white white ADJ fnp-9165 143 3 matter matter PROPN fnp-9165 143 4 pathways pathway NOUN fnp-9165 143 5 remain remain VERB fnp-9165 143 6 non non ADJ fnp-9165 143 7 - - ADJ fnp-9165 143 8 reactive reactive ADJ fnp-9165 143 9 throughout throughout ADP fnp-9165 143 10 fetal fetal ADJ fnp-9165 143 11 and and CCONJ fnp-9165 143 12 postnatal postnatal ADJ fnp-9165 143 13 life life NOUN fnp-9165 143 14 . . PUNCT fnp-9165 144 1 bergmann bergmann PROPN fnp-9165 144 2 glia glia PROPN fnp-9165 144 3 are be AUX fnp-9165 144 4 nonreactive nonreactive ADJ fnp-9165 144 5 at at ADP fnp-9165 144 6 all all DET fnp-9165 144 7 gestational gestational ADJ fnp-9165 144 8 ages age NOUN fnp-9165 144 9 . . PUNCT fnp-9165 145 1 transitory transitory ADJ fnp-9165 145 2 parasagittal parasagittal ADJ fnp-9165 145 3 ks ks NOUN fnp-9165 145 4 septa septum NOUN fnp-9165 145 5 demarcate demarcate VERB fnp-9165 145 6 vermis vermis NOUN fnp-9165 145 7 / / SYM fnp-9165 145 8 hemispheric hemispheric ADJ fnp-9165 145 9 boundary boundary NOUN fnp-9165 145 10 . . PUNCT fnp-9165 146 1 ks ks NOUN fnp-9165 146 2 is be AUX fnp-9165 146 3 not not PART fnp-9165 146 4 expressed express VERB fnp-9165 146 5 in in ADP fnp-9165 146 6 dandy dandy NOUN fnp-9165 146 7 - - PUNCT fnp-9165 146 8 walker walker NOUN fnp-9165 146 9 , , PUNCT fnp-9165 146 10 joubert joubert PROPN fnp-9165 146 11 or or CCONJ fnp-9165 146 12 chiari chiari NOUN fnp-9165 146 13 malformations malformation NOUN fnp-9165 146 14 , , PUNCT fnp-9165 146 15 pontocerebellar pontocerebellar ADJ fnp-9165 146 16 hypoplasia hypoplasia NOUN fnp-9165 146 17 or or CCONJ fnp-9165 146 18 cerebellar cerebellar ADJ fnp-9165 146 19 heterotopia heterotopia PROPN fnp-9165 146 20 . . PUNCT fnp-9165 147 1 axonal axonal ADJ fnp-9165 147 2 fascicles fascicle NOUN fnp-9165 147 3 of of ADP fnp-9165 147 4 the the DET fnp-9165 147 5 corticospinal corticospinal ADJ fnp-9165 147 6 tract tract NOUN fnp-9165 147 7 caudal caudal NOUN fnp-9165 147 8 to to ADP fnp-9165 147 9 the the DET fnp-9165 147 10 internal internal ADJ fnp-9165 147 11 capsule capsule NOUN fnp-9165 147 12 do do AUX fnp-9165 147 13 not not PART fnp-9165 147 14 exhibit exhibit VERB fnp-9165 147 15 ks ks NOUN fnp-9165 147 16 reactivity reactivity NOUN fnp-9165 147 17 . . PUNCT fnp-9165 148 1 synaptophysin synaptophysin NOUN fnp-9165 148 2 in in ADP fnp-9165 148 3 cerebellar cerebellar ADJ fnp-9165 148 4 system system NOUN fnp-9165 148 5 was be AUX fnp-9165 148 6 normal normal ADJ fnp-9165 148 7 . . PUNCT fnp-9165 149 1 absence absence NOUN fnp-9165 149 2 of of ADP fnp-9165 149 3 hindbrain hindbrain NOUN fnp-9165 149 4 ks ks PROPN fnp-9165 149 5 contrasts contrast VERB fnp-9165 149 6 with with ADP fnp-9165 149 7 strong strong ADJ fnp-9165 149 8 forebrain forebrain NOUN fnp-9165 149 9 reactivity reactivity NOUN fnp-9165 149 10 . . PUNCT fnp-9165 150 1 lack lack NOUN fnp-9165 150 2 of of ADP fnp-9165 150 3 ks ks NOUN fnp-9165 150 4 expression expression NOUN fnp-9165 150 5 in in ADP fnp-9165 150 6 normally normally ADV fnp-9165 150 7 developing develop VERB fnp-9165 150 8 cerebellum cerebellum ADJ fnp-9165 150 9 and and CCONJ fnp-9165 150 10 associated associated ADJ fnp-9165 150 11 brainstem brainstem NOUN fnp-9165 150 12 nuclei nucleus NOUN fnp-9165 150 13 except except SCONJ fnp-9165 150 14 pontine pontine NOUN fnp-9165 150 15 , , PUNCT fnp-9165 150 16 and and CCONJ fnp-9165 150 17 its its PRON fnp-9165 150 18 absence absence NOUN fnp-9165 150 19 in in ADP fnp-9165 150 20 cerebellar cerebellar ADJ fnp-9165 150 21 dysgeneses dysgenese NOUN fnp-9165 150 22 implies imply VERB fnp-9165 150 23 that that SCONJ fnp-9165 150 24 ks ks PROPN fnp-9165 150 25 does do AUX fnp-9165 150 26 not not PART fnp-9165 150 27 contribute contribute VERB fnp-9165 150 28 to to ADP fnp-9165 150 29 pathogenesis pathogenesis NOUN fnp-9165 150 30 in in ADP fnp-9165 150 31 cerebellar cerebellar ADJ fnp-9165 150 32 system system NOUN fnp-9165 150 33 malformations malformation NOUN fnp-9165 150 34 . . PUNCT fnp-9165 151 1 transitory transitory ADJ fnp-9165 151 2 ks ks NOUN fnp-9165 151 3 septa septum NOUN fnp-9165 151 4 define define VERB fnp-9165 151 5 early early ADJ fnp-9165 151 6 vermal vermal ADJ fnp-9165 151 7 margins margin NOUN fnp-9165 151 8 , , PUNCT fnp-9165 151 9 similar similar ADJ fnp-9165 151 10 to to ADP fnp-9165 151 11 septa septum NOUN fnp-9165 151 12 of of ADP fnp-9165 151 13 neuromeric neuromeric ADJ fnp-9165 151 14 segmentation segmentation NOUN fnp-9165 151 15 . . PUNCT fnp-9165 152 1 the the DET fnp-9165 152 2 intense intense ADJ fnp-9165 152 3 ks ks NOUN fnp-9165 152 4 template template NOUN fnp-9165 152 5 of of ADP fnp-9165 152 6 the the DET fnp-9165 152 7 internal internal ADJ fnp-9165 152 8 capsule capsule NOUN fnp-9165 152 9 does do AUX fnp-9165 152 10 not not PART fnp-9165 152 11 extend extend VERB fnp-9165 152 12 caudally caudally ADV fnp-9165 152 13 to to ADP fnp-9165 152 14 brainstem brainstem NOUN fnp-9165 152 15 fascicles fascicle NOUN fnp-9165 152 16 . . PUNCT fnp-9165 152 17     SPACE fnp-9165 153 1 abstract abstract ADJ fnp-9165 153 2 15 15 NUM fnp-9165 153 3 free free ADJ fnp-9165 153 4 neuropathol neuropathol NOUN fnp-9165 153 5 6:23:20 6:23:20 NUM fnp-9165 153 6 chromogenic chromogenic ADJ fnp-9165 153 7 in in ADP fnp-9165 153 8 situ situ ADJ fnp-9165 153 9 hybridization hybridization NOUN fnp-9165 153 10 for for ADP fnp-9165 153 11 detection detection NOUN fnp-9165 153 12 of of ADP fnp-9165 153 13 cdkn2a cdkn2a PROPN fnp-9165 153 14 / / SYM fnp-9165 153 15 b b NOUN fnp-9165 153 16 homozygous homozygous ADJ fnp-9165 153 17 deletion deletion NOUN fnp-9165 153 18 karina karina PROPN fnp-9165 153 19 c. c. PROPN fnp-9165 153 20 martin1,2 martin1,2 PROPN fnp-9165 153 21 , , PUNCT fnp-9165 153 22 tara tara PROPN fnp-9165 153 23 spence1,2 spence1,2 PROPN fnp-9165 153 24 , , PUNCT fnp-9165 153 25 janine janine PROPN fnp-9165 153 26 senz2 senz2 PROPN fnp-9165 153 27 , , PUNCT fnp-9165 153 28 julia julia PROPN fnp-9165 153 29 naso1,2 naso1,2 PROPN fnp-9165 153 30 , , PUNCT fnp-9165 153 31 andrew andrew PROPN fnp-9165 153 32 churg1,2 churg1,2 PROPN fnp-9165 153 33 , , PUNCT fnp-9165 153 34 stephen stephen PROPN fnp-9165 153 35 yip1,2 yip1,2 PROPN fnp-9165 153 36 department department PROPN fnp-9165 153 37 of of ADP fnp-9165 153 38 pathology pathology PROPN fnp-9165 153 39 , , PUNCT fnp-9165 153 40 vancouver vancouver PROPN fnp-9165 153 41 general general PROPN fnp-9165 153 42 hospital hospital PROPN fnp-9165 153 43 , , PUNCT fnp-9165 153 44 vancouver vancouver PROPN fnp-9165 153 45 , , PUNCT fnp-9165 153 46 canada canada PROPN fnp-9165 153 47 department department PROPN fnp-9165 153 48 of of ADP fnp-9165 153 49 pathology pathology PROPN fnp-9165 153 50 and and CCONJ fnp-9165 153 51 laboratory laboratory NOUN fnp-9165 153 52 medicine medicine NOUN fnp-9165 153 53 , , PUNCT fnp-9165 153 54 university university NOUN fnp-9165 153 55 of of ADP fnp-9165 153 56 british british PROPN fnp-9165 153 57 columbia columbia PROPN fnp-9165 153 58 , , PUNCT fnp-9165 153 59 vancouver vancouver PROPN fnp-9165 153 60 , , PUNCT fnp-9165 153 61 canada canada PROPN fnp-9165 153 62 the the DET fnp-9165 153 63 presence presence NOUN fnp-9165 153 64 of of ADP fnp-9165 153 65 cdkn2a cdkn2a PROPN fnp-9165 153 66 / / SYM fnp-9165 153 67 b b NOUN fnp-9165 153 68 homozygous homozygous ADJ fnp-9165 153 69 deletion deletion NOUN fnp-9165 153 70 ( ( PUNCT fnp-9165 153 71 hd hd NOUN fnp-9165 153 72 ) ) PUNCT fnp-9165 153 73 denotes denote VERB fnp-9165 153 74 a a DET fnp-9165 153 75 higher high ADJ fnp-9165 153 76 who who PRON fnp-9165 153 77 grade grade VERB fnp-9165 153 78 and and CCONJ fnp-9165 153 79 more more ADV fnp-9165 153 80 aggressive aggressive ADJ fnp-9165 153 81 behavior behavior NOUN fnp-9165 153 82 in in ADP fnp-9165 153 83 gliomas glioma NOUN fnp-9165 153 84 and and CCONJ fnp-9165 153 85 meningiomas meningioma NOUN fnp-9165 153 86 . . PUNCT fnp-9165 154 1 the the DET fnp-9165 154 2 gold gold ADJ fnp-9165 154 3 standard standard NOUN fnp-9165 154 4 assays assay NOUN fnp-9165 154 5 for for ADP fnp-9165 154 6 detecting detect VERB fnp-9165 154 7 copy copy NOUN fnp-9165 154 8 number number NOUN fnp-9165 154 9 variation variation NOUN fnp-9165 154 10 ( ( PUNCT fnp-9165 154 11 cnv cnv NOUN fnp-9165 154 12 ) ) PUNCT fnp-9165 154 13 include include VERB fnp-9165 154 14 chromosomal chromosomal ADJ fnp-9165 154 15 microarray microarray NOUN fnp-9165 154 16 , , PUNCT fnp-9165 154 17 next next ADJ fnp-9165 154 18 generation generation NOUN fnp-9165 154 19 sequencing sequence VERB fnp-9165 154 20 , , PUNCT fnp-9165 154 21 and and CCONJ fnp-9165 154 22 fluorescence fluorescence NOUN fnp-9165 154 23 in in ADP fnp-9165 154 24 situ situ ADJ fnp-9165 154 25 hybridization hybridization NOUN fnp-9165 154 26 ( ( PUNCT fnp-9165 154 27 fish fish NOUN fnp-9165 154 28 ) ) PUNCT fnp-9165 154 29 . . PUNCT fnp-9165 155 1 however however ADV fnp-9165 155 2 , , PUNCT fnp-9165 155 3 these these DET fnp-9165 155 4 methods method NOUN fnp-9165 155 5 are be AUX fnp-9165 155 6 costly costly ADJ fnp-9165 155 7 , , PUNCT fnp-9165 155 8 time time NOUN fnp-9165 155 9 consuming consuming NOUN fnp-9165 155 10 , , PUNCT fnp-9165 155 11 and and CCONJ fnp-9165 155 12 have have VERB fnp-9165 155 13 limited limit VERB fnp-9165 155 14 availability availability NOUN fnp-9165 155 15 in in ADP fnp-9165 155 16 resource resource NOUN fnp-9165 155 17 - - PUNCT fnp-9165 155 18 sparse sparse ADJ fnp-9165 155 19 centers center NOUN fnp-9165 155 20 . . PUNCT fnp-9165 156 1 thus thus ADV fnp-9165 156 2 , , PUNCT fnp-9165 156 3 an an DET fnp-9165 156 4 inexpensive inexpensive ADJ fnp-9165 156 5 and and CCONJ fnp-9165 156 6 time time NOUN fnp-9165 156 7 - - PUNCT fnp-9165 156 8 efficient efficient ADJ fnp-9165 156 9 assay assay NOUN fnp-9165 156 10 for for ADP fnp-9165 156 11 detecting detect VERB fnp-9165 156 12 cdkn2a cdkn2a PROPN fnp-9165 156 13 / / SYM fnp-9165 156 14 b b PROPN fnp-9165 156 15 hd hd NOUN fnp-9165 156 16 would would AUX fnp-9165 156 17 be be AUX fnp-9165 156 18 helpful helpful ADJ fnp-9165 156 19 for for ADP fnp-9165 156 20 routine routine ADJ fnp-9165 156 21 neuropathology neuropathology NOUN fnp-9165 156 22 cases case NOUN fnp-9165 156 23 . . PUNCT fnp-9165 157 1 chromogenic chromogenic ADJ fnp-9165 157 2 in in ADP fnp-9165 157 3 situ situ ADJ fnp-9165 157 4 hybridization hybridization NOUN fnp-9165 157 5 ( ( PUNCT fnp-9165 157 6 cish cish NOUN fnp-9165 157 7 ) ) PUNCT fnp-9165 157 8 combines combine VERB fnp-9165 157 9 dna dna PROPN fnp-9165 157 10 hybridization hybridization NOUN fnp-9165 157 11 techniques technique NOUN fnp-9165 157 12 utilized utilize VERB fnp-9165 157 13 in in ADP fnp-9165 157 14 fish fish NOUN fnp-9165 157 15 with with ADP fnp-9165 157 16 conventional conventional ADJ fnp-9165 157 17 peroxidase peroxidase NOUN fnp-9165 157 18 reactions reaction NOUN fnp-9165 157 19 utilized utilize VERB fnp-9165 157 20 in in ADP fnp-9165 157 21 immunohistochemistry immunohistochemistry NOUN fnp-9165 157 22 to to PART fnp-9165 157 23 interrogate interrogate VERB fnp-9165 157 24 cnv cnv PROPN fnp-9165 157 25 with with ADP fnp-9165 157 26 brightfield brightfield NOUN fnp-9165 157 27 microscopy microscopy NOUN fnp-9165 157 28 . . PUNCT fnp-9165 158 1 we we PRON fnp-9165 158 2 hypothesize hypothesize VERB fnp-9165 158 3 that that SCONJ fnp-9165 158 4 cish cish NOUN fnp-9165 158 5 is be AUX fnp-9165 158 6 a a DET fnp-9165 158 7 sensitive sensitive ADJ fnp-9165 158 8 and and CCONJ fnp-9165 158 9 specific specific ADJ fnp-9165 158 10 method method NOUN fnp-9165 158 11 for for ADP fnp-9165 158 12 detecting detect VERB fnp-9165 158 13 cdkn2a cdkn2a PROPN fnp-9165 158 14 / / SYM fnp-9165 158 15 b b PROPN fnp-9165 158 16 hd hd NOUN fnp-9165 158 17 . . PUNCT fnp-9165 159 1 we we PRON fnp-9165 159 2 performed perform VERB fnp-9165 159 3 cdkn2a cdkn2a PROPN fnp-9165 159 4 cish cish NOUN fnp-9165 159 5 on on ADP fnp-9165 159 6 a a DET fnp-9165 159 7 retrospective retrospective ADJ fnp-9165 159 8 cohort cohort NOUN fnp-9165 159 9 of of ADP fnp-9165 159 10 whole whole ADJ fnp-9165 159 11 slide slide NOUN fnp-9165 159 12 tissue tissue NOUN fnp-9165 159 13 sections section NOUN fnp-9165 159 14 of of ADP fnp-9165 159 15 5 5 NUM fnp-9165 159 16 gliomas glioma NOUN fnp-9165 159 17 and and CCONJ fnp-9165 159 18 10 10 NUM fnp-9165 159 19 meningiomas meningioma NOUN fnp-9165 159 20 using use VERB fnp-9165 159 21 the the DET fnp-9165 159 22 abnova abnova PROPN fnp-9165 159 23 cdkn2a cdkn2a PROPN fnp-9165 159 24 / / SYM fnp-9165 159 25 cep9 cep9 ADJ fnp-9165 159 26 cish cish NOUN fnp-9165 159 27 probes probe NOUN fnp-9165 159 28 and and CCONJ fnp-9165 159 29 implementation implementation NOUN fnp-9165 159 30 kit kit NOUN fnp-9165 159 31 . . PUNCT fnp-9165 160 1 two two NUM fnp-9165 160 2 pathologists pathologist NOUN fnp-9165 160 3 independently independently ADV fnp-9165 160 4 counted count VERB fnp-9165 160 5 and and CCONJ fnp-9165 160 6 scored score VERB fnp-9165 160 7 100 100 NUM fnp-9165 160 8 cells cell NOUN fnp-9165 160 9 from from ADP fnp-9165 160 10 each each DET fnp-9165 160 11 case case NOUN fnp-9165 160 12 showing show VERB fnp-9165 160 13 any any DET fnp-9165 160 14 cep9 cep9 NOUN fnp-9165 160 15 ( ( PUNCT fnp-9165 160 16 red red ADJ fnp-9165 160 17 / / SYM fnp-9165 160 18 control control NOUN fnp-9165 160 19 ) ) PUNCT fnp-9165 160 20 signals signal NOUN fnp-9165 160 21 and and CCONJ fnp-9165 160 22 no no DET fnp-9165 160 23 cdkn2a cdkn2a PROPN fnp-9165 160 24 ( ( PUNCT fnp-9165 160 25 green green ADJ fnp-9165 160 26 ) ) PUNCT fnp-9165 160 27 signals signal NOUN fnp-9165 160 28 as as ADP fnp-9165 160 29 hd hd NOUN fnp-9165 160 30 , , PUNCT fnp-9165 160 31 and and CCONJ fnp-9165 160 32 cells cell NOUN fnp-9165 160 33 showing show VERB fnp-9165 160 34 both both CCONJ fnp-9165 160 35 red red ADJ fnp-9165 160 36 and and CCONJ fnp-9165 160 37 green green ADJ fnp-9165 160 38 signals signal NOUN fnp-9165 160 39 as as ADP fnp-9165 160 40 cdkn2a cdkn2a PROPN fnp-9165 160 41 / / SYM fnp-9165 160 42 b b NOUN fnp-9165 160 43 intact intact ADJ fnp-9165 160 44 . . PUNCT fnp-9165 161 1 the the DET fnp-9165 161 2 pathologists pathologist NOUN fnp-9165 161 3 ’ ' PUNCT fnp-9165 161 4 scores score NOUN fnp-9165 161 5 were be AUX fnp-9165 161 6 averaged average VERB fnp-9165 161 7 and and CCONJ fnp-9165 161 8 compared compare VERB fnp-9165 161 9 to to ADP fnp-9165 161 10 the the DET fnp-9165 161 11 cdkn2a cdkn2a PROPN fnp-9165 161 12 / / SYM fnp-9165 161 13 b b PROPN fnp-9165 161 14 status status NOUN fnp-9165 161 15 for for ADP fnp-9165 161 16 each each PRON fnp-9165 161 17 of of ADP fnp-9165 161 18 the the DET fnp-9165 161 19 glioma glioma NOUN fnp-9165 161 20 and and CCONJ fnp-9165 161 21 meningioma meningioma NOUN fnp-9165 161 22 cases case NOUN fnp-9165 161 23 , , PUNCT fnp-9165 161 24 acquired acquire VERB fnp-9165 161 25 via via ADP fnp-9165 161 26 fish fish NOUN fnp-9165 161 27 testing testing NOUN fnp-9165 161 28 and and CCONJ fnp-9165 161 29 methylation methylation NOUN fnp-9165 161 30 profiling profiling NOUN fnp-9165 161 31 , , PUNCT fnp-9165 161 32 respectively respectively ADV fnp-9165 161 33 . . PUNCT fnp-9165 162 1 our our PRON fnp-9165 162 2 results result NOUN fnp-9165 162 3 demonstrate demonstrate VERB fnp-9165 162 4 that that SCONJ fnp-9165 162 5 detection detection NOUN fnp-9165 162 6 of of ADP fnp-9165 162 7 cdkn2a cdkn2a PROPN fnp-9165 162 8 / / SYM fnp-9165 162 9 b b PROPN fnp-9165 162 10 hd hd NOUN fnp-9165 162 11 with with ADP fnp-9165 162 12 cish cish NOUN fnp-9165 162 13 showed show VERB fnp-9165 162 14 high high ADJ fnp-9165 162 15 concordance concordance NOUN fnp-9165 162 16 with with ADP fnp-9165 162 17 cdkn2a cdkn2a PROPN fnp-9165 162 18 / / SYM fnp-9165 162 19 b b NOUN fnp-9165 162 20 locus locus ADJ fnp-9165 162 21 interrogation interrogation NOUN fnp-9165 162 22 with with ADP fnp-9165 162 23 orthogonal orthogonal ADJ fnp-9165 162 24 assays assay NOUN fnp-9165 162 25 . . PUNCT fnp-9165 163 1 cish cish NOUN fnp-9165 163 2 is be AUX fnp-9165 163 3 a a DET fnp-9165 163 4 sensitive sensitive ADJ fnp-9165 163 5 and and CCONJ fnp-9165 163 6 specific specific ADJ fnp-9165 163 7 method method NOUN fnp-9165 163 8 for for ADP fnp-9165 163 9 detecting detect VERB fnp-9165 163 10 cdkn2a cdkn2a PROPN fnp-9165 163 11 / / SYM fnp-9165 163 12 b b PROPN fnp-9165 163 13 hd hd PROPN fnp-9165 163 14 in in ADP fnp-9165 163 15 glioma glioma NOUN fnp-9165 163 16 and and CCONJ fnp-9165 163 17 meningioma meningioma NOUN fnp-9165 163 18 and and CCONJ fnp-9165 163 19 is be AUX fnp-9165 163 20 a a DET fnp-9165 163 21 more more ADV fnp-9165 163 22 cost cost NOUN fnp-9165 163 23 - - PUNCT fnp-9165 163 24 effective effective ADJ fnp-9165 163 25 and and CCONJ fnp-9165 163 26 practical practical ADJ fnp-9165 163 27 alternative alternative NOUN fnp-9165 163 28 to to ADP fnp-9165 163 29 traditional traditional ADJ fnp-9165 163 30 cnv cnv NOUN fnp-9165 163 31 detection detection NOUN fnp-9165 163 32 methods method NOUN fnp-9165 163 33 . . PUNCT fnp-9165 163 34     SPACE fnp-9165 164 1 abstract abstract ADJ fnp-9165 164 2 16 16 NUM fnp-9165 164 3 free free ADJ fnp-9165 164 4 neuropathol neuropathol NOUN fnp-9165 164 5 6:23:21 6:23:21 NUM fnp-9165 164 6 routine routine ADJ fnp-9165 164 7 immunohistochemical immunohistochemical ADJ fnp-9165 164 8 assessment assessment NOUN fnp-9165 164 9 of of ADP fnp-9165 164 10 mismatch mismatch ADJ fnp-9165 164 11 repair repair NOUN fnp-9165 164 12 proteins protein NOUN fnp-9165 164 13 in in ADP fnp-9165 164 14 high high ADJ fnp-9165 164 15 - - PUNCT fnp-9165 164 16 grade grade NOUN fnp-9165 164 17 gliomas glioma NOUN fnp-9165 164 18 : : PUNCT fnp-9165 164 19 retrospective retrospective ADJ fnp-9165 164 20 analysis analysis NOUN fnp-9165 164 21 and and CCONJ fnp-9165 164 22 clinical clinical ADJ fnp-9165 164 23 implications implication NOUN fnp-9165 164 24 jacob jacob PROPN fnp-9165 164 25 a. a. PROPN fnp-9165 164 26 houpt1 houpt1 PROPN fnp-9165 164 27 , , PUNCT fnp-9165 164 28 lee lee PROPN fnp-9165 164 29 cyn cyn PROPN fnp-9165 164 30 ang1 ang1 PROPN fnp-9165 164 31 department department PROPN fnp-9165 164 32 of of ADP fnp-9165 164 33 pathology pathology PROPN fnp-9165 164 34 and and CCONJ fnp-9165 164 35 laboratory laboratory NOUN fnp-9165 164 36 medicine medicine NOUN fnp-9165 164 37 , , PUNCT fnp-9165 164 38 london london PROPN fnp-9165 164 39 health health PROPN fnp-9165 164 40 sciences sciences PROPN fnp-9165 164 41 centre centre PROPN fnp-9165 164 42 , , PUNCT fnp-9165 164 43 london london PROPN fnp-9165 164 44 , , PUNCT fnp-9165 164 45 canada canada PROPN fnp-9165 164 46 testing test VERB fnp-9165 164 47 for for ADP fnp-9165 164 48 deficiencies deficiency NOUN fnp-9165 164 49 in in ADP fnp-9165 164 50 mismatch mismatch ADJ fnp-9165 164 51 repair repair NOUN fnp-9165 164 52 ( ( PUNCT fnp-9165 164 53 mmr mmr PROPN fnp-9165 164 54 ) ) PUNCT fnp-9165 164 55 proteins protein NOUN fnp-9165 164 56 ( ( PUNCT fnp-9165 164 57 mlh1 mlh1 PROPN fnp-9165 164 58 , , PUNCT fnp-9165 164 59 pms2 pms2 NOUN fnp-9165 164 60 , , PUNCT fnp-9165 164 61 msh2 msh2 NOUN fnp-9165 164 62 , , PUNCT fnp-9165 164 63 and and CCONJ fnp-9165 164 64 msh6 msh6 NOUN fnp-9165 164 65 ) ) PUNCT fnp-9165 164 66 via via ADP fnp-9165 164 67 immunohistochemistry immunohistochemistry NOUN fnp-9165 164 68 ( ( PUNCT fnp-9165 164 69 ihc ihc PROPN fnp-9165 164 70 ) ) PUNCT fnp-9165 164 71 has have AUX fnp-9165 164 72 become become VERB fnp-9165 164 73 a a DET fnp-9165 164 74 widely widely ADV fnp-9165 164 75 - - PUNCT fnp-9165 164 76 adopted adopt VERB fnp-9165 164 77 means mean NOUN fnp-9165 164 78 of of ADP fnp-9165 164 79 screening screen VERB fnp-9165 164 80 for for ADP fnp-9165 164 81 tumour tumour NOUN fnp-9165 164 82 predisposition predisposition NOUN fnp-9165 164 83 syndromes syndrome NOUN fnp-9165 164 84 and and CCONJ fnp-9165 164 85 for for ADP fnp-9165 164 86 informing inform VERB fnp-9165 164 87 potential potential ADJ fnp-9165 164 88 immunotherapeutic immunotherapeutic ADJ fnp-9165 164 89 treatment treatment NOUN fnp-9165 164 90 options option NOUN fnp-9165 164 91 . . PUNCT fnp-9165 165 1 while while SCONJ fnp-9165 165 2 some some DET fnp-9165 165 3 centres centre NOUN fnp-9165 165 4 rely rely VERB fnp-9165 165 5 on on ADP fnp-9165 165 6 ihc ihc PROPN fnp-9165 165 7 for for ADP fnp-9165 165 8 all all DET fnp-9165 165 9 4 4 NUM fnp-9165 165 10 mmr mmr NOUN fnp-9165 165 11 proteins protein NOUN fnp-9165 165 12 , , PUNCT fnp-9165 165 13 others other NOUN fnp-9165 165 14 have have AUX fnp-9165 165 15 relied rely VERB fnp-9165 165 16 on on ADP fnp-9165 165 17 a a DET fnp-9165 165 18 more more ADV fnp-9165 165 19 cost cost NOUN fnp-9165 165 20 - - PUNCT fnp-9165 165 21 effective effective ADJ fnp-9165 165 22 means mean NOUN fnp-9165 165 23 of of ADP fnp-9165 165 24 screening screen VERB fnp-9165 165 25 only only ADV fnp-9165 165 26 the the DET fnp-9165 165 27 secondary secondary ADJ fnp-9165 165 28 partner partner NOUN fnp-9165 165 29 proteins protein NOUN fnp-9165 165 30 pms2 pms2 NOUN fnp-9165 165 31 and and CCONJ fnp-9165 165 32 msh6 msh6 NOUN fnp-9165 165 33 ( ( PUNCT fnp-9165 165 34 as as SCONJ fnp-9165 165 35 losses loss NOUN fnp-9165 165 36 of of ADP fnp-9165 165 37 mlh1 mlh1 PROPN fnp-9165 165 38 / / SYM fnp-9165 165 39 msh2 msh2 NOUN fnp-9165 165 40 are be AUX fnp-9165 165 41 expected expect VERB fnp-9165 165 42 to to PART fnp-9165 165 43 result result VERB fnp-9165 165 44 in in ADP fnp-9165 165 45 degradation degradation NOUN fnp-9165 165 46 of of ADP fnp-9165 165 47 pms2 pms2 PROPN fnp-9165 165 48 / / SYM fnp-9165 165 49 msh6s msh6s PROPN fnp-9165 165 50 ) ) PUNCT fnp-9165 165 51 . . PUNCT fnp-9165 166 1 just just ADV fnp-9165 166 2 under under ADP fnp-9165 166 3 2 2 NUM fnp-9165 166 4 years year NOUN fnp-9165 166 5 ago ago ADV fnp-9165 166 6 , , PUNCT fnp-9165 166 7 cancer cancer NOUN fnp-9165 166 8 care care PROPN fnp-9165 166 9 ontario ontario PROPN fnp-9165 166 10 ( ( PUNCT fnp-9165 166 11 cco cco PROPN fnp-9165 166 12 ) ) PUNCT fnp-9165 166 13 began begin VERB fnp-9165 166 14 to to PART fnp-9165 166 15 fund fund VERB fnp-9165 166 16 routine routine PROPN fnp-9165 166 17 mmr mmr PROPN fnp-9165 166 18 ihc ihc PROPN fnp-9165 166 19 testing testing NOUN fnp-9165 166 20 on on ADP fnp-9165 166 21 all all DET fnp-9165 166 22 high high ADJ fnp-9165 166 23 - - PUNCT fnp-9165 166 24 grade grade NOUN fnp-9165 166 25 gliomas glioma NOUN fnp-9165 166 26 ( ( PUNCT fnp-9165 166 27 hggs hgg NOUN fnp-9165 166 28 ) ) PUNCT fnp-9165 166 29 . . PUNCT fnp-9165 167 1 london london PROPN fnp-9165 167 2 health health PROPN fnp-9165 167 3 sciences sciences PROPN fnp-9165 167 4 centre centre PROPN fnp-9165 167 5 has have AUX fnp-9165 167 6 thus thus ADV fnp-9165 167 7 far far ADV fnp-9165 167 8 tested test VERB fnp-9165 167 9 132 132 NUM fnp-9165 167 10 of of ADP fnp-9165 167 11 these these DET fnp-9165 167 12 tumours tumour NOUN fnp-9165 167 13 for for ADP fnp-9165 167 14 all all DET fnp-9165 167 15 4 4 NUM fnp-9165 167 16 mmr mmr NOUN fnp-9165 167 17 proteins protein NOUN fnp-9165 167 18 via via ADP fnp-9165 167 19 ihc ihc PROPN fnp-9165 167 20 . . PUNCT fnp-9165 168 1 of of ADP fnp-9165 168 2 these these PRON fnp-9165 168 3 , , PUNCT fnp-9165 168 4 4 4 NUM fnp-9165 168 5 ( ( PUNCT fnp-9165 168 6 approximately approximately ADV fnp-9165 168 7 3 3 NUM fnp-9165 168 8     SPACE fnp-9165 168 9 % % NOUN fnp-9165 168 10 ) ) PUNCT fnp-9165 168 11 were be AUX fnp-9165 168 12 found find VERB fnp-9165 168 13 to to PART fnp-9165 168 14 have have VERB fnp-9165 168 15 a a DET fnp-9165 168 16 loss loss NOUN fnp-9165 168 17 of of ADP fnp-9165 168 18 mmr mmr PROPN fnp-9165 168 19 immunopositivity immunopositivity NOUN fnp-9165 168 20 ( ( PUNCT fnp-9165 168 21 2 2 NUM fnp-9165 168 22 for for ADP fnp-9165 168 23 msh6 msh6 NOUN fnp-9165 168 24 , , PUNCT fnp-9165 168 25 2 2 NUM fnp-9165 168 26 for for ADP fnp-9165 168 27 pms2 pms2 NOUN fnp-9165 168 28 ) ) PUNCT fnp-9165 168 29 . . PUNCT fnp-9165 169 1 these these DET fnp-9165 169 2 cases case NOUN fnp-9165 169 3 had have VERB fnp-9165 169 4 particularly particularly ADV fnp-9165 169 5 elevated elevate VERB fnp-9165 169 6 nuclear nuclear ADJ fnp-9165 169 7 pleomorphism pleomorphism NOUN fnp-9165 169 8 when when SCONJ fnp-9165 169 9 compared compare VERB fnp-9165 169 10 to to ADP fnp-9165 169 11 most most ADJ fnp-9165 169 12 other other ADJ fnp-9165 169 13 hggs hgg NOUN fnp-9165 169 14 and and CCONJ fnp-9165 169 15 involved involve VERB fnp-9165 169 16 sporadic sporadic ADJ fnp-9165 169 17 loss loss NOUN fnp-9165 169 18 of of ADP fnp-9165 169 19 msh6 msh6 NOUN fnp-9165 169 20 ( ( PUNCT fnp-9165 169 21 with with ADP fnp-9165 169 22 negative negative ADJ fnp-9165 169 23 germline germline NOUN fnp-9165 169 24 testing testing NOUN fnp-9165 169 25 for for ADP fnp-9165 169 26 lynch lynch PROPN fnp-9165 169 27 syndrome syndrome PROPN fnp-9165 169 28 ) ) PUNCT fnp-9165 169 29 , , PUNCT fnp-9165 169 30 loss loss NOUN fnp-9165 169 31 of of ADP fnp-9165 169 32 msh6 msh6 NOUN fnp-9165 169 33 secondary secondary ADJ fnp-9165 169 34 to to PART fnp-9165 169 35 temozolomide temozolomide VERB fnp-9165 169 36 chemotherapy chemotherapy NOUN fnp-9165 169 37 ( ( PUNCT fnp-9165 169 38 with with ADP fnp-9165 169 39 intact intact ADJ fnp-9165 169 40 mmr mmr PROPN fnp-9165 169 41 in in ADP fnp-9165 169 42 the the DET fnp-9165 169 43 original original ADJ fnp-9165 169 44 tumour tumour NOUN fnp-9165 169 45 ) ) PUNCT fnp-9165 169 46 , , PUNCT fnp-9165 169 47 and and CCONJ fnp-9165 169 48 biallelic biallelic ADJ fnp-9165 169 49 loss loss NOUN fnp-9165 169 50 of of ADP fnp-9165 169 51 pms2 pms2 NOUN fnp-9165 169 52 in in ADP fnp-9165 169 53 the the DET fnp-9165 169 54 context context NOUN fnp-9165 169 55 of of ADP fnp-9165 169 56 2 2 NUM fnp-9165 169 57 cases case NOUN fnp-9165 169 58 of of ADP fnp-9165 169 59 congenital congenital ADJ fnp-9165 169 60 mismatch mismatch NOUN fnp-9165 169 61 repair repair NOUN fnp-9165 169 62 deficiency deficiency NOUN fnp-9165 169 63 syndrome syndrome NOUN fnp-9165 169 64 ( ( PUNCT fnp-9165 169 65 cmmrd cmmrd PROPN fnp-9165 169 66 ) ) PUNCT fnp-9165 169 67 . . PUNCT fnp-9165 170 1 this this DET fnp-9165 170 2 ihc ihc PROPN fnp-9165 170 3 approach approach NOUN fnp-9165 170 4 has have AUX fnp-9165 170 5 been be AUX fnp-9165 170 6 efficacious efficacious ADJ fnp-9165 170 7 in in ADP fnp-9165 170 8 contributing contribute VERB fnp-9165 170 9 towards towards ADP fnp-9165 170 10 the the DET fnp-9165 170 11 diagnosis diagnosis NOUN fnp-9165 170 12 of of ADP fnp-9165 170 13 tumour tumour ADJ fnp-9165 170 14 predisposition predisposition NOUN fnp-9165 170 15 syndromes syndrome NOUN fnp-9165 170 16 , , PUNCT fnp-9165 170 17 identifying identify VERB fnp-9165 170 18 monoallelic monoallelic ADJ fnp-9165 170 19 versus versus ADP fnp-9165 170 20 biallelic biallelic ADJ fnp-9165 170 21 loss loss NOUN fnp-9165 170 22 of of ADP fnp-9165 170 23 mmr mmr PROPN fnp-9165 170 24 proteins protein NOUN fnp-9165 170 25 , , PUNCT fnp-9165 170 26 and and CCONJ fnp-9165 170 27 providing provide VERB fnp-9165 170 28 potential potential ADJ fnp-9165 170 29 targets target NOUN fnp-9165 170 30 for for ADP fnp-9165 170 31 immunomodulatory immunomodulatory ADJ fnp-9165 170 32 therapies therapy NOUN fnp-9165 170 33 . . PUNCT fnp-9165 171 1 furthermore furthermore ADV fnp-9165 171 2 , , PUNCT fnp-9165 171 3 these these DET fnp-9165 171 4 results result NOUN fnp-9165 171 5 support support VERB fnp-9165 171 6 the the DET fnp-9165 171 7 use use NOUN fnp-9165 171 8 of of ADP fnp-9165 171 9 a a DET fnp-9165 171 10 two two NUM fnp-9165 171 11 - - PUNCT fnp-9165 171 12 antibody antibody NOUN fnp-9165 171 13 mmr mmr PROPN fnp-9165 171 14 ihc ihc PROPN fnp-9165 171 15 screening screening NOUN fnp-9165 171 16 approach approach NOUN fnp-9165 171 17 relying rely VERB fnp-9165 171 18 solely solely ADV fnp-9165 171 19 on on ADP fnp-9165 171 20 msh6 msh6 NOUN fnp-9165 171 21 and and CCONJ fnp-9165 171 22 pms2 pms2 PROPN fnp-9165 171 23 . . PUNCT fnp-9165 171 24     SPACE fnp-9165 172 1 abstract abstract ADJ fnp-9165 172 2 17 17 NUM fnp-9165 172 3 free free ADJ fnp-9165 172 4 neuropathol neuropathol NOUN fnp-9165 172 5 6:23:22 6:23:22 NUM fnp-9165 172 6 malignant malignant ADJ fnp-9165 172 7 transformation transformation NOUN fnp-9165 172 8 of of ADP fnp-9165 172 9 craniopharyngioma craniopharyngioma NOUN fnp-9165 172 10 with with ADP fnp-9165 172 11 spinal spinal ADJ fnp-9165 172 12 metastasis metastasis NOUN fnp-9165 172 13 : : PUNCT fnp-9165 172 14 a a DET fnp-9165 172 15 case case NOUN fnp-9165 172 16 report report NOUN fnp-9165 172 17 and and CCONJ fnp-9165 172 18 comprehensive comprehensive ADJ fnp-9165 172 19 literature literature NOUN fnp-9165 172 20 review review PROPN fnp-9165 172 21 pramath pramath PROPN fnp-9165 172 22 kakodkar1 kakodkar1 PROPN fnp-9165 172 23 , , PUNCT fnp-9165 172 24 gina gina PROPN fnp-9165 172 25 martin2 martin2 PROPN fnp-9165 172 26 , , PUNCT fnp-9165 172 27 julia julia PROPN fnp-9165 172 28 radic3 radic3 PROPN fnp-9165 172 29 , , PUNCT fnp-9165 172 30 vijayanada vijayanada PROPN fnp-9165 172 31 kundapur4 kundapur4 PROPN fnp-9165 172 32 , , PUNCT fnp-9165 172 33 adrian adrian PROPN fnp-9165 172 34 b. b. PROPN fnp-9165 172 35 levine5 levine5 PROPN fnp-9165 172 36 , , PUNCT fnp-9165 172 37 viktor viktor PROPN fnp-9165 172 38 zherebitskiy1 zherebitskiy1 PROPN fnp-9165 172 39 , , PUNCT fnp-9165 172 40 roland roland PROPN fnp-9165 172 41 n. n. PROPN fnp-9165 172 42 auer1 auer1 PROPN fnp-9165 172 43 department department PROPN fnp-9165 172 44 of of ADP fnp-9165 172 45 pathology pathology PROPN fnp-9165 172 46 and and CCONJ fnp-9165 172 47 laboratory laboratory PROPN fnp-9165 172 48 medicine medicine PROPN fnp-9165 172 49 university university PROPN fnp-9165 172 50 of of ADP fnp-9165 172 51 saskatchewan saskatchewan PROPN fnp-9165 172 52 and and CCONJ fnp-9165 172 53 saskatchewan saskatchewan PROPN fnp-9165 172 54 health health PROPN fnp-9165 172 55 authority authority PROPN fnp-9165 172 56 , , PUNCT fnp-9165 172 57 saskatoon saskatoon PROPN fnp-9165 172 58 , , PUNCT fnp-9165 172 59 canada canada PROPN fnp-9165 172 60 division division NOUN fnp-9165 172 61 of of ADP fnp-9165 172 62 pediatric pediatric ADJ fnp-9165 172 63 hematology hematology NOUN fnp-9165 172 64 - - PUNCT fnp-9165 172 65 oncology oncology NOUN fnp-9165 172 66 , , PUNCT fnp-9165 172 67 saskatoon saskatoon PROPN fnp-9165 172 68 cancer cancer PROPN fnp-9165 172 69 center center PROPN fnp-9165 172 70 , , PUNCT fnp-9165 172 71 saskatoon saskatoon PROPN fnp-9165 172 72 , , PUNCT fnp-9165 172 73 canada canada PROPN fnp-9165 172 74 division division NOUN fnp-9165 172 75 of of ADP fnp-9165 172 76 neurosurgery neurosurgery NOUN fnp-9165 172 77 , , PUNCT fnp-9165 172 78 dalhousie dalhousie PROPN fnp-9165 172 79 university university PROPN fnp-9165 172 80 , , PUNCT fnp-9165 172 81 halifax halifax PROPN fnp-9165 172 82 , , PUNCT fnp-9165 172 83 canada canada PROPN fnp-9165 172 84 division division NOUN fnp-9165 172 85 of of ADP fnp-9165 172 86 radiation radiation NOUN fnp-9165 172 87 oncology oncology NOUN fnp-9165 172 88 , , PUNCT fnp-9165 172 89 saskatoon saskatoon PROPN fnp-9165 172 90 cancer cancer PROPN fnp-9165 172 91 center center PROPN fnp-9165 172 92 , , PUNCT fnp-9165 172 93 saskatoon saskatoon PROPN fnp-9165 172 94 , , PUNCT fnp-9165 172 95 canada canada PROPN fnp-9165 172 96 department department PROPN fnp-9165 172 97 of of ADP fnp-9165 172 98 laboratory laboratory NOUN fnp-9165 172 99 medicine medicine NOUN fnp-9165 172 100 and and CCONJ fnp-9165 172 101 pathobiology pathobiology NOUN fnp-9165 172 102 , , PUNCT fnp-9165 172 103 university university PROPN fnp-9165 172 104 of of ADP fnp-9165 172 105 toronto toronto PROPN fnp-9165 172 106 , , PUNCT fnp-9165 172 107 toronto toronto PROPN fnp-9165 172 108 , , PUNCT fnp-9165 172 109 canada canada PROPN fnp-9165 172 110 malignant malignant ADJ fnp-9165 172 111 transformation transformation NOUN fnp-9165 172 112 of of ADP fnp-9165 172 113 craniopharyngioma craniopharyngioma NOUN fnp-9165 172 114 is be AUX fnp-9165 172 115 exceedingly exceedingly ADV fnp-9165 172 116 rare rare ADJ fnp-9165 172 117 with with ADP fnp-9165 172 118 few few ADJ fnp-9165 172 119 cases case NOUN fnp-9165 172 120 characterized characterize VERB fnp-9165 172 121 by by ADP fnp-9165 172 122 systemic systemic ADJ fnp-9165 172 123 spread spread NOUN fnp-9165 172 124 or or CCONJ fnp-9165 172 125 molecularly molecularly ADV fnp-9165 172 126 confirmed confirm VERB fnp-9165 172 127 clonal clonal ADJ fnp-9165 172 128 progression progression NOUN fnp-9165 172 129 . . PUNCT fnp-9165 173 1 we we PRON fnp-9165 173 2 present present VERB fnp-9165 173 3 a a DET fnp-9165 173 4 pediatric pediatric ADJ fnp-9165 173 5 case case NOUN fnp-9165 173 6 of of ADP fnp-9165 173 7 adamantinomatous adamantinomatous ADJ fnp-9165 173 8 craniopharyngioma craniopharyngioma NOUN fnp-9165 173 9 that that PRON fnp-9165 173 10 evolved evolve VERB fnp-9165 173 11 over over ADP fnp-9165 173 12 12 12 NUM fnp-9165 173 13 years year NOUN fnp-9165 173 14 into into ADP fnp-9165 173 15 a a DET fnp-9165 173 16 high high ADJ fnp-9165 173 17 - - PUNCT fnp-9165 173 18 grade grade NOUN fnp-9165 173 19 epithelial epithelial ADJ fnp-9165 173 20 neoplasm neoplasm NOUN fnp-9165 173 21 with with ADP fnp-9165 173 22 clival clival NOUN fnp-9165 173 23 extension extension NOUN fnp-9165 173 24 and and CCONJ fnp-9165 173 25 spinal spinal NOUN fnp-9165 173 26 metastases metastasis NOUN fnp-9165 173 27 causing cause VERB fnp-9165 173 28 vertebral vertebral ADJ fnp-9165 173 29 fracture fracture NOUN fnp-9165 173 30 and and CCONJ fnp-9165 173 31 spinal spinal ADJ fnp-9165 173 32 cord cord NOUN fnp-9165 173 33 compression compression NOUN fnp-9165 173 34 ; ; PUNCT fnp-9165 173 35 to to ADP fnp-9165 173 36 our our PRON fnp-9165 173 37 knowledge knowledge NOUN fnp-9165 173 38 , , PUNCT fnp-9165 173 39 this this PRON fnp-9165 173 40 is be AUX fnp-9165 173 41 the the DET fnp-9165 173 42 3rd 3rd ADJ fnp-9165 173 43 case case NOUN fnp-9165 173 44 of of ADP fnp-9165 173 45 spinal spinal ADJ fnp-9165 173 46 dissemination dissemination NOUN fnp-9165 173 47 in in ADP fnp-9165 173 48 the the DET fnp-9165 173 49 literature literature NOUN fnp-9165 173 50 . . PUNCT fnp-9165 174 1 the the DET fnp-9165 174 2 transformed transform VERB fnp-9165 174 3 tumor tumor NOUN fnp-9165 174 4 demonstrated demonstrate VERB fnp-9165 174 5 high high ADJ fnp-9165 174 6 - - PUNCT fnp-9165 174 7 grade grade NOUN fnp-9165 174 8 epithelial epithelial ADJ fnp-9165 174 9 morphology morphology NOUN fnp-9165 174 10 ( ( PUNCT fnp-9165 174 11 ki-67 ki-67 NUM fnp-9165 174 12 : : PUNCT fnp-9165 174 13 100 100 NUM fnp-9165 174 14     SPACE fnp-9165 174 15 % % NOUN fnp-9165 174 16 vs vs ADP fnp-9165 174 17 5 5 NUM fnp-9165 174 18     SPACE fnp-9165 174 19 % % NOUN fnp-9165 174 20 initially initially ADV fnp-9165 174 21 ) ) PUNCT fnp-9165 174 22 , , PUNCT fnp-9165 174 23 strong strong ADJ fnp-9165 174 24 pancytokeratin pancytokeratin ADJ fnp-9165 174 25 and and CCONJ fnp-9165 174 26 vimentin vimentin ADJ fnp-9165 174 27 expression expression NOUN fnp-9165 174 28 , , PUNCT fnp-9165 174 29 partial partial ADJ fnp-9165 174 30 h3 h3 NOUN fnp-9165 174 31 k27me3 k27me3 PROPN fnp-9165 174 32 loss loss NOUN fnp-9165 174 33 , , PUNCT fnp-9165 174 34 and and CCONJ fnp-9165 174 35 absence absence NOUN fnp-9165 174 36 of of ADP fnp-9165 174 37 glial glial ADJ fnp-9165 174 38 or or CCONJ fnp-9165 174 39 neuroendocrine neuroendocrine ADJ fnp-9165 174 40 differentiation differentiation NOUN fnp-9165 174 41 . . PUNCT fnp-9165 175 1 molecular molecular ADJ fnp-9165 175 2 profiling profiling NOUN fnp-9165 175 3 confirmed confirm VERB fnp-9165 175 4 the the DET fnp-9165 175 5 same same ADJ fnp-9165 175 6 ctnnb1 ctnnb1 NOUN fnp-9165 175 7 p.s33c p.s33c NOUN fnp-9165 175 8 mutation mutation NOUN fnp-9165 175 9 in in ADP fnp-9165 175 10 both both CCONJ fnp-9165 175 11 the the DET fnp-9165 175 12 initial initial ADJ fnp-9165 175 13 and and CCONJ fnp-9165 175 14 transformed transform VERB fnp-9165 175 15 tumor tumor NOUN fnp-9165 175 16 , , PUNCT fnp-9165 175 17 along along ADP fnp-9165 175 18 with with ADP fnp-9165 175 19 a a DET fnp-9165 175 20 segmental segmental ADJ fnp-9165 175 21 1p 1p NUM fnp-9165 175 22 deletion deletion NOUN fnp-9165 175 23 acquired acquire VERB fnp-9165 175 24 in in ADP fnp-9165 175 25 the the DET fnp-9165 175 26 latter latter ADJ fnp-9165 175 27 , , PUNCT fnp-9165 175 28 supporting support VERB fnp-9165 175 29 molecularly molecularly ADV fnp-9165 175 30 confirmed confirm VERB fnp-9165 175 31 clonal clonal ADJ fnp-9165 175 32 evolution evolution NOUN fnp-9165 175 33 . . PUNCT fnp-9165 176 1 a a DET fnp-9165 176 2 systematic systematic ADJ fnp-9165 176 3 review review NOUN fnp-9165 176 4 ( ( PUNCT fnp-9165 176 5 n n CCONJ fnp-9165 176 6     SPACE fnp-9165 176 7 = = NOUN fnp-9165 176 8     SPACE fnp-9165 176 9 35 35 NUM fnp-9165 176 10 ) ) PUNCT fnp-9165 176 11 on on ADP fnp-9165 176 12 craniopharyngioma craniopharyngioma ADJ fnp-9165 176 13 cases case NOUN fnp-9165 176 14 with with ADP fnp-9165 176 15 malignant malignant ADJ fnp-9165 176 16 transformation transformation NOUN fnp-9165 176 17 revealed reveal VERB fnp-9165 176 18 consistent consistent ADJ fnp-9165 176 19 epithelial epithelial ADJ fnp-9165 176 20 immunophenotype immunophenotype NOUN fnp-9165 176 21 , , PUNCT fnp-9165 176 22 frequent frequent ADJ fnp-9165 176 23 p53 p53 NOUN fnp-9165 176 24 overexpression overexpression NOUN fnp-9165 176 25 ( ( PUNCT fnp-9165 176 26 89 89 NUM fnp-9165 176 27     SPACE fnp-9165 176 28 % % NOUN fnp-9165 176 29 , , PUNCT fnp-9165 176 30 n n CCONJ fnp-9165 176 31     SPACE fnp-9165 176 32 = = NOUN fnp-9165 176 33     SPACE fnp-9165 176 34 17 17 NUM fnp-9165 176 35 ) ) PUNCT fnp-9165 176 36 , , PUNCT fnp-9165 176 37 high high ADJ fnp-9165 176 38 mean mean NOUN fnp-9165 176 39 ki-67 ki-67 X fnp-9165 176 40 ( ( PUNCT fnp-9165 176 41 41 41 NUM fnp-9165 176 42     SPACE fnp-9165 176 43 ± ± NOUN fnp-9165 176 44     SPACE fnp-9165 176 45 21 21 NUM fnp-9165 176 46     SPACE fnp-9165 176 47 % % NOUN fnp-9165 176 48 ) ) PUNCT fnp-9165 176 49 . . PUNCT fnp-9165 177 1 more more ADJ fnp-9165 177 2 surgeries surgery NOUN fnp-9165 177 3 were be AUX fnp-9165 177 4 significantly significantly ADV fnp-9165 177 5 associated associate VERB fnp-9165 177 6 with with ADP fnp-9165 177 7 longer long ADJ fnp-9165 177 8 time time NOUN fnp-9165 177 9 to to ADP fnp-9165 177 10 transformation transformation NOUN fnp-9165 177 11 ( ( PUNCT fnp-9165 177 12 r r NOUN fnp-9165 177 13     SPACE fnp-9165 177 14 = = NOUN fnp-9165 177 15     SPACE fnp-9165 177 16 0.49 0.49 NUM fnp-9165 177 17 , , PUNCT fnp-9165 177 18 p p X fnp-9165 177 19     SPACE fnp-9165 177 20 = = NOUN fnp-9165 177 21     SPACE fnp-9165 177 22 0.005 0.005 NUM fnp-9165 177 23 ) ) PUNCT fnp-9165 177 24 , , PUNCT fnp-9165 177 25 suggesting suggest VERB fnp-9165 177 26 that that SCONJ fnp-9165 177 27 multiple multiple ADJ fnp-9165 177 28 surgical surgical ADJ fnp-9165 177 29 interventions intervention NOUN fnp-9165 177 30 delayed delay VERB fnp-9165 177 31 progression progression NOUN fnp-9165 177 32 , , PUNCT fnp-9165 177 33 while while SCONJ fnp-9165 177 34 no no DET fnp-9165 177 35 significant significant ADJ fnp-9165 177 36 correlation correlation NOUN fnp-9165 177 37 was be AUX fnp-9165 177 38 observed observe VERB fnp-9165 177 39 with with ADP fnp-9165 177 40 radiation radiation NOUN fnp-9165 177 41 dose dose NOUN fnp-9165 177 42 ( ( PUNCT fnp-9165 177 43 r r NOUN fnp-9165 177 44     SPACE fnp-9165 177 45 = = NOUN fnp-9165 177 46     SPACE fnp-9165 177 47 0.01 0.01 NUM fnp-9165 177 48 , , PUNCT fnp-9165 177 49 p p X fnp-9165 177 50     SPACE fnp-9165 177 51 = = NOUN fnp-9165 177 52     SPACE fnp-9165 177 53 0.97 0.97 NUM fnp-9165 177 54 ) ) PUNCT fnp-9165 177 55 or or CCONJ fnp-9165 177 56 tumor tumor NOUN fnp-9165 177 57 size size NOUN fnp-9165 177 58 ( ( PUNCT fnp-9165 177 59 r r NOUN fnp-9165 177 60     SPACE fnp-9165 177 61 = = NOUN fnp-9165 177 62     SPACE fnp-9165 177 63 0.40 0.40 NUM fnp-9165 177 64 , , PUNCT fnp-9165 177 65 p p X fnp-9165 177 66     SPACE fnp-9165 177 67 = = NOUN fnp-9165 177 68     SPACE fnp-9165 177 69 0.16 0.16 NUM fnp-9165 177 70 ) ) PUNCT fnp-9165 177 71 . . PUNCT fnp-9165 178 1 these these DET fnp-9165 178 2 findings finding NOUN fnp-9165 178 3 support support VERB fnp-9165 178 4 a a DET fnp-9165 178 5 clonal clonal ADJ fnp-9165 178 6 evolution evolution NOUN fnp-9165 178 7 model model NOUN fnp-9165 178 8 and and CCONJ fnp-9165 178 9 highlight highlight VERB fnp-9165 178 10 the the DET fnp-9165 178 11 importance importance NOUN fnp-9165 178 12 of of ADP fnp-9165 178 13 molecular molecular ADJ fnp-9165 178 14 surveillance surveillance NOUN fnp-9165 178 15 in in ADP fnp-9165 178 16 long long ADV fnp-9165 178 17 - - PUNCT fnp-9165 178 18 standing stand VERB fnp-9165 178 19 craniopharyngiomas craniopharyngioma NOUN fnp-9165 178 20 . . PUNCT fnp-9165 178 21     SPACE fnp-9165 179 1 abstract abstract ADJ fnp-9165 179 2 18 18 NUM fnp-9165 179 3 free free ADJ fnp-9165 179 4 neuropathol neuropathol NOUN fnp-9165 179 5 6:23:23 6:23:23 NUM fnp-9165 179 6 methylation methylation NOUN fnp-9165 179 7 classification classification NOUN fnp-9165 179 8 in in ADP fnp-9165 179 9 meningioma meningioma NOUN fnp-9165 179 10 prognostication prognostication NOUN fnp-9165 179 11 : : PUNCT fnp-9165 179 12 strengths strength NOUN fnp-9165 179 13 and and CCONJ fnp-9165 179 14 caveats caveat NOUN fnp-9165 179 15 shane shane PROPN fnp-9165 179 16 eaton1 eaton1 PROPN fnp-9165 179 17 , , PUNCT fnp-9165 179 18 robert robert PROPN fnp-9165 179 19 siddaway2 siddaway2 PROPN fnp-9165 179 20 , , PUNCT fnp-9165 179 21 anthony anthony PROPN fnp-9165 179 22 arnoldo3 arnoldo3 PROPN fnp-9165 179 23 , , PUNCT fnp-9165 179 24 arun arun PROPN fnp-9165 179 25 vadivel3 vadivel3 PROPN fnp-9165 179 26 , , PUNCT fnp-9165 179 27 adrian adrian PROPN fnp-9165 179 28 levine1,4 levine1,4 PROPN fnp-9165 179 29 , , PUNCT fnp-9165 179 30 cynthia cynthia PROPN fnp-9165 179 31 hawkins1,4 hawkins1,4 PROPN fnp-9165 179 32 department department PROPN fnp-9165 179 33 of of ADP fnp-9165 179 34 laboratory laboratory NOUN fnp-9165 179 35 medicine medicine NOUN fnp-9165 179 36 and and CCONJ fnp-9165 179 37 pathobiology pathobiology NOUN fnp-9165 179 38 , , PUNCT fnp-9165 179 39 university university PROPN fnp-9165 179 40 of of ADP fnp-9165 179 41 toronto toronto PROPN fnp-9165 179 42 , , PUNCT fnp-9165 179 43 toronto toronto PROPN fnp-9165 179 44 , , PUNCT fnp-9165 179 45 canada canada PROPN fnp-9165 179 46 arthur arthur PROPN fnp-9165 179 47 and and CCONJ fnp-9165 179 48 sonia sonia PROPN fnp-9165 179 49 labatt labatt PROPN fnp-9165 179 50 brain brain VERB fnp-9165 179 51 tumour tumour NOUN fnp-9165 179 52 research research NOUN fnp-9165 179 53 centre centre NOUN fnp-9165 179 54 , , PUNCT fnp-9165 179 55 the the DET fnp-9165 179 56 hospital hospital NOUN fnp-9165 179 57 for for ADP fnp-9165 179 58 sick sick ADJ fnp-9165 179 59 children child NOUN fnp-9165 179 60 , , PUNCT fnp-9165 179 61 toronto toronto PROPN fnp-9165 179 62 , , PUNCT fnp-9165 179 63 canada canada PROPN fnp-9165 179 64 department department PROPN fnp-9165 179 65 of of ADP fnp-9165 179 66 paediatric paediatric ADJ fnp-9165 179 67 laboratory laboratory NOUN fnp-9165 179 68 medicine medicine NOUN fnp-9165 179 69 , , PUNCT fnp-9165 179 70 the the DET fnp-9165 179 71 hospital hospital NOUN fnp-9165 179 72 for for ADP fnp-9165 179 73 sick sick ADJ fnp-9165 179 74 children child NOUN fnp-9165 179 75 , , PUNCT fnp-9165 179 76 toronto toronto PROPN fnp-9165 179 77 , , PUNCT fnp-9165 179 78 canada canada PROPN fnp-9165 179 79 department department PROPN fnp-9165 179 80 of of ADP fnp-9165 179 81 pathology pathology PROPN fnp-9165 179 82 , , PUNCT fnp-9165 179 83 the the DET fnp-9165 179 84 hospital hospital NOUN fnp-9165 179 85 for for ADP fnp-9165 179 86 sick sick ADJ fnp-9165 179 87 children child NOUN fnp-9165 179 88 , , PUNCT fnp-9165 179 89 toronto toronto PROPN fnp-9165 179 90 , , PUNCT fnp-9165 179 91 canada canada PROPN fnp-9165 179 92 dna dna PROPN fnp-9165 179 93 methylation methylation NOUN fnp-9165 179 94 patterns pattern NOUN fnp-9165 179 95 have have AUX fnp-9165 179 96 emerged emerge VERB fnp-9165 179 97 as as ADP fnp-9165 179 98 a a DET fnp-9165 179 99 useful useful ADJ fnp-9165 179 100 signature signature NOUN fnp-9165 179 101 for for ADP fnp-9165 179 102 classifying classify VERB fnp-9165 179 103 brain brain NOUN fnp-9165 179 104 tumours tumour NOUN fnp-9165 179 105 . . PUNCT fnp-9165 180 1 these these DET fnp-9165 180 2 patterns pattern NOUN fnp-9165 180 3 tend tend VERB fnp-9165 180 4 to to PART fnp-9165 180 5 be be AUX fnp-9165 180 6 consistent consistent ADJ fnp-9165 180 7 within within ADP fnp-9165 180 8 tumour tumour NOUN fnp-9165 180 9 entities entity NOUN fnp-9165 180 10 and and CCONJ fnp-9165 180 11 even even ADV fnp-9165 180 12 within within ADP fnp-9165 180 13 subtypes subtype NOUN fnp-9165 180 14 , , PUNCT fnp-9165 180 15 and and CCONJ fnp-9165 180 16 have have AUX fnp-9165 180 17 proved prove VERB fnp-9165 180 18 to to PART fnp-9165 180 19 be be AUX fnp-9165 180 20 a a DET fnp-9165 180 21 helpful helpful ADJ fnp-9165 180 22 tool tool NOUN fnp-9165 180 23 in in ADP fnp-9165 180 24 resolving resolve VERB fnp-9165 180 25 diagnostically diagnostically ADV fnp-9165 180 26 challenging challenging ADJ fnp-9165 180 27 cases case NOUN fnp-9165 180 28 . . PUNCT fnp-9165 181 1 however however ADV fnp-9165 181 2 , , PUNCT fnp-9165 181 3 methylation methylation NOUN fnp-9165 181 4 classification classification NOUN fnp-9165 181 5 is be AUX fnp-9165 181 6 not not PART fnp-9165 181 7 always always ADV fnp-9165 181 8 reliable reliable ADJ fnp-9165 181 9 . . PUNCT fnp-9165 182 1 in in ADP fnp-9165 182 2 particular particular ADJ fnp-9165 182 3 , , PUNCT fnp-9165 182 4 in in ADP fnp-9165 182 5 light light NOUN fnp-9165 182 6 of of ADP fnp-9165 182 7 the the DET fnp-9165 182 8 recent recent ADJ fnp-9165 182 9 cimpact cimpact ADJ fnp-9165 182 10 - - PUNCT fnp-9165 182 11 now now ADV fnp-9165 182 12 guidelines guideline NOUN fnp-9165 182 13 for for ADP fnp-9165 182 14 meningioma meningioma ADJ fnp-9165 182 15 prognostication prognostication NOUN fnp-9165 182 16 , , PUNCT fnp-9165 182 17 inconsistencies inconsistency NOUN fnp-9165 182 18 have have AUX fnp-9165 182 19 appeared appear VERB fnp-9165 182 20 between between ADP fnp-9165 182 21 the the DET fnp-9165 182 22 prognostic prognostic ADJ fnp-9165 182 23 subtypes subtype NOUN fnp-9165 182 24 defined define VERB fnp-9165 182 25 by by ADP fnp-9165 182 26 methylation methylation NOUN fnp-9165 182 27 profiling profiling NOUN fnp-9165 182 28 and and CCONJ fnp-9165 182 29 the the DET fnp-9165 182 30 grading grading NOUN fnp-9165 182 31 recommended recommend VERB fnp-9165 182 32 on on ADP fnp-9165 182 33 the the DET fnp-9165 182 34 basis basis NOUN fnp-9165 182 35 of of ADP fnp-9165 182 36 copy copy NOUN fnp-9165 182 37 number number NOUN fnp-9165 182 38 profiles profile NOUN fnp-9165 182 39 . . PUNCT fnp-9165 183 1 to to PART fnp-9165 183 2 explore explore VERB fnp-9165 183 3 this this PRON fnp-9165 183 4 , , PUNCT fnp-9165 183 5 we we PRON fnp-9165 183 6 reviewed review VERB fnp-9165 183 7 methylation methylation NOUN fnp-9165 183 8 results result NOUN fnp-9165 183 9 from from ADP fnp-9165 183 10 cases case NOUN fnp-9165 183 11 at at ADP fnp-9165 183 12 sickkids sickkid NOUN fnp-9165 183 13 hospital hospital NOUN fnp-9165 183 14 , , PUNCT fnp-9165 183 15 focusing focus VERB fnp-9165 183 16 on on ADP fnp-9165 183 17 areas area NOUN fnp-9165 183 18 of of ADP fnp-9165 183 19 concordance concordance NOUN fnp-9165 183 20 and and CCONJ fnp-9165 183 21 discordance discordance NOUN fnp-9165 183 22 . . PUNCT fnp-9165 184 1 from from ADP fnp-9165 184 2 841 841 NUM fnp-9165 184 3 total total ADJ fnp-9165 184 4 methylation methylation NOUN fnp-9165 184 5 cases case NOUN fnp-9165 184 6 , , PUNCT fnp-9165 184 7 46 46 NUM fnp-9165 184 8 were be AUX fnp-9165 184 9 meningiomas meningioma NOUN fnp-9165 184 10 . . PUNCT fnp-9165 185 1 within within ADP fnp-9165 185 2 this this DET fnp-9165 185 3 group group NOUN fnp-9165 185 4 13 13 NUM fnp-9165 185 5     SPACE fnp-9165 185 6 % % NOUN fnp-9165 185 7 showed show VERB fnp-9165 185 8 discordant discordant ADJ fnp-9165 185 9 prognostication prognostication NOUN fnp-9165 185 10 between between ADP fnp-9165 185 11 methylation methylation NOUN fnp-9165 185 12 subtyping subtype VERB fnp-9165 185 13 and and CCONJ fnp-9165 185 14 the the DET fnp-9165 185 15 copy copy NOUN fnp-9165 185 16 number number NOUN fnp-9165 185 17 - - PUNCT fnp-9165 185 18 based base VERB fnp-9165 185 19 stratification stratification NOUN fnp-9165 185 20 described describe VERB fnp-9165 185 21 in in ADP fnp-9165 185 22 cimpact cimpact ADJ fnp-9165 185 23 - - PUNCT fnp-9165 185 24 now now ADV fnp-9165 185 25 update update NOUN fnp-9165 185 26 8 8 NUM fnp-9165 185 27 . . PUNCT fnp-9165 186 1 we we PRON fnp-9165 186 2 present present VERB fnp-9165 186 3 several several ADJ fnp-9165 186 4 illustrative illustrative ADJ fnp-9165 186 5 cases case NOUN fnp-9165 186 6 to to PART fnp-9165 186 7 highlight highlight VERB fnp-9165 186 8 when when SCONJ fnp-9165 186 9 methylation methylation NOUN fnp-9165 186 10 was be AUX fnp-9165 186 11 useful useful ADJ fnp-9165 186 12 , , PUNCT fnp-9165 186 13 when when SCONJ fnp-9165 186 14 it it PRON fnp-9165 186 15 led lead VERB fnp-9165 186 16 to to ADP fnp-9165 186 17 conflicting conflicting ADJ fnp-9165 186 18 results result NOUN fnp-9165 186 19 , , PUNCT fnp-9165 186 20 and and CCONJ fnp-9165 186 21 the the DET fnp-9165 186 22 factors factor NOUN fnp-9165 186 23 contributing contribute VERB fnp-9165 186 24 to to ADP fnp-9165 186 25 the the DET fnp-9165 186 26 discordance discordance NOUN fnp-9165 186 27 . . PUNCT fnp-9165 187 1 previous previous ADJ fnp-9165 187 2 studies study NOUN fnp-9165 187 3 have have AUX fnp-9165 187 4 suggested suggest VERB fnp-9165 187 5 a a DET fnp-9165 187 6 multi multi ADJ fnp-9165 187 7 - - ADJ fnp-9165 187 8 factorial factorial ADJ fnp-9165 187 9 approach approach NOUN fnp-9165 187 10 to to ADP fnp-9165 187 11 meningioma meningioma NOUN fnp-9165 187 12 grading grading NOUN fnp-9165 187 13 and and CCONJ fnp-9165 187 14 prognostication prognostication NOUN fnp-9165 187 15 underscored underscore VERB fnp-9165 187 16 by by ADP fnp-9165 187 17 our our PRON fnp-9165 187 18 results result NOUN fnp-9165 187 19 . . PUNCT fnp-9165 188 1 how how SCONJ fnp-9165 188 2 to to PART fnp-9165 188 3 approach approach VERB fnp-9165 188 4 grading grade VERB fnp-9165 188 5 in in ADP fnp-9165 188 6 the the DET fnp-9165 188 7 setting setting NOUN fnp-9165 188 8 of of ADP fnp-9165 188 9 discordant discordant ADJ fnp-9165 188 10 findings finding NOUN fnp-9165 188 11 will will AUX fnp-9165 188 12 require require VERB fnp-9165 188 13 further further ADJ fnp-9165 188 14 study study NOUN fnp-9165 188 15 with with ADP fnp-9165 188 16 well well ADV fnp-9165 188 17 annotated annotate VERB fnp-9165 188 18 clinical clinical ADJ fnp-9165 188 19 outcome outcome NOUN fnp-9165 188 20 data datum NOUN fnp-9165 188 21 . . PUNCT fnp-9165 189 1 while while SCONJ fnp-9165 189 2 methylation methylation NOUN fnp-9165 189 3 can can AUX fnp-9165 189 4 be be AUX fnp-9165 189 5 a a DET fnp-9165 189 6 powerful powerful ADJ fnp-9165 189 7 diagnostic diagnostic NOUN fnp-9165 189 8 adjunct adjunct ADJ fnp-9165 189 9 , , PUNCT fnp-9165 189 10 these these PRON fnp-9165 189 11 results result NOUN fnp-9165 189 12 caution caution VERB fnp-9165 189 13 against against ADP fnp-9165 189 14 overreliance overreliance NOUN fnp-9165 189 15 on on ADP fnp-9165 189 16 this this DET fnp-9165 189 17 method method NOUN fnp-9165 189 18 alone alone ADV fnp-9165 189 19 for for ADP fnp-9165 189 20 meningioma meningioma NOUN fnp-9165 189 21 classification classification NOUN fnp-9165 189 22 and and CCONJ fnp-9165 189 23 prognostication prognostication NOUN fnp-9165 189 24 . . PUNCT fnp-9165 189 25     SPACE fnp-9165 190 1 abstract abstract ADJ fnp-9165 190 2 19 19 NUM fnp-9165 190 3 free free ADJ fnp-9165 190 4 neuropathol neuropathol NOUN fnp-9165 190 5 6:23:24 6:23:24 NUM fnp-9165 190 6 liquid liquid ADJ fnp-9165 190 7 biopsy biopsy NOUN fnp-9165 190 8 for for ADP fnp-9165 190 9 cns cns PROPN fnp-9165 190 10 tumours tumours PROPN fnp-9165 190 11 yoshiko yoshiko PROPN fnp-9165 190 12 nakano1 nakano1 PROPN fnp-9165 190 13 , , PUNCT fnp-9165 190 14 robert robert PROPN fnp-9165 190 15 siddaway2 siddaway2 PROPN fnp-9165 190 16 , , PUNCT fnp-9165 190 17 liana liana PROPN fnp-9165 190 18 nobre3 nobre3 PROPN fnp-9165 190 19 , , PUNCT fnp-9165 190 20 ian ian PROPN fnp-9165 190 21 burns4 burns4 PROPN fnp-9165 190 22 , , PUNCT fnp-9165 190 23 mansuba mansuba PROPN fnp-9165 190 24 rana2 rana2 PROPN fnp-9165 190 25 , , PUNCT fnp-9165 190 26 richard richard PROPN fnp-9165 190 27 yuditskiy2 yuditskiy2 PROPN fnp-9165 190 28 , , PUNCT fnp-9165 190 29 cyril cyril PROPN fnp-9165 190 30 li2 li2 PROPN fnp-9165 190 31 , , PUNCT fnp-9165 190 32 julie julie PROPN fnp-9165 190 33 bennett1 bennett1 PROPN fnp-9165 190 34 , , PUNCT fnp-9165 190 35 anthony anthony PROPN fnp-9165 190 36 liu1 liu1 PROPN fnp-9165 190 37 , , PUNCT fnp-9165 190 38 uri uri PROPN fnp-9165 190 39 tabori1 tabori1 PROPN fnp-9165 190 40 , , PUNCT fnp-9165 190 41 cynthia cynthia NOUN fnp-9165 190 42 hawkins2 hawkins2 NOUN fnp-9165 190 43 division division NOUN fnp-9165 190 44 of of ADP fnp-9165 190 45 haematology haematology NOUN fnp-9165 190 46 / / SYM fnp-9165 190 47 oncology oncology NOUN fnp-9165 190 48 , , PUNCT fnp-9165 190 49 the the DET fnp-9165 190 50 hospital hospital NOUN fnp-9165 190 51 for for ADP fnp-9165 190 52 sick sick ADJ fnp-9165 190 53 children child NOUN fnp-9165 190 54 , , PUNCT fnp-9165 190 55 toronto toronto PROPN fnp-9165 190 56 , , PUNCT fnp-9165 190 57 canada canada PROPN fnp-9165 190 58 department department PROPN fnp-9165 190 59 of of ADP fnp-9165 190 60 paediatric paediatric ADJ fnp-9165 190 61 laboratory laboratory NOUN fnp-9165 190 62 medicine medicine NOUN fnp-9165 190 63 , , PUNCT fnp-9165 190 64 the the DET fnp-9165 190 65 hospital hospital NOUN fnp-9165 190 66 for for ADP fnp-9165 190 67 sick sick ADJ fnp-9165 190 68 children child NOUN fnp-9165 190 69 , , PUNCT fnp-9165 190 70 toronto toronto PROPN fnp-9165 190 71 , , PUNCT fnp-9165 190 72 canada canada PROPN fnp-9165 190 73 department department PROPN fnp-9165 190 74 of of ADP fnp-9165 190 75 paediatrics paediatric NOUN fnp-9165 190 76 , , PUNCT fnp-9165 190 77 university university NOUN fnp-9165 190 78 of of ADP fnp-9165 190 79 alberta alberta PROPN fnp-9165 190 80 , , PUNCT fnp-9165 190 81 edmonton edmonton PROPN fnp-9165 190 82 , , PUNCT fnp-9165 190 83 canada canada PROPN fnp-9165 190 84 department department PROPN fnp-9165 190 85 of of ADP fnp-9165 190 86 paediatrics paediatric NOUN fnp-9165 190 87 , , PUNCT fnp-9165 190 88 the the DET fnp-9165 190 89 hospital hospital NOUN fnp-9165 190 90 for for ADP fnp-9165 190 91 sick sick ADJ fnp-9165 190 92 children child NOUN fnp-9165 190 93 , , PUNCT fnp-9165 190 94 toronto toronto PROPN fnp-9165 190 95 , , PUNCT fnp-9165 190 96 canada canada PROPN fnp-9165 190 97 liquid liquid PROPN fnp-9165 190 98 biopsy biopsy NOUN fnp-9165 190 99 ( ( PUNCT fnp-9165 190 100 lb lb NOUN fnp-9165 190 101 ) ) PUNCT fnp-9165 190 102 is be AUX fnp-9165 190 103 an an DET fnp-9165 190 104 emerging emerge VERB fnp-9165 190 105 diagnostic diagnostic ADJ fnp-9165 190 106 tool tool NOUN fnp-9165 190 107 for for ADP fnp-9165 190 108 detecting detect VERB fnp-9165 190 109 tumor tumor NOUN fnp-9165 190 110 - - PUNCT fnp-9165 190 111 specific specific ADJ fnp-9165 190 112 alterations alteration NOUN fnp-9165 190 113 in in ADP fnp-9165 190 114 body body NOUN fnp-9165 190 115 fluids fluid NOUN fnp-9165 190 116 that that PRON fnp-9165 190 117 has have VERB fnp-9165 190 118 many many ADJ fnp-9165 190 119 potential potential ADJ fnp-9165 190 120 advantages advantage NOUN fnp-9165 190 121 including include VERB fnp-9165 190 122 : : PUNCT fnp-9165 190 123 identifying identify VERB fnp-9165 190 124 tumors tumor NOUN fnp-9165 190 125 with with ADP fnp-9165 190 126 higher high ADJ fnp-9165 190 127 sensitivity sensitivity NOUN fnp-9165 190 128 and and CCONJ fnp-9165 190 129 specificity specificity NOUN fnp-9165 190 130 than than ADP fnp-9165 190 131 imaging imaging NOUN fnp-9165 190 132 ; ; PUNCT fnp-9165 190 133 replacing replace VERB fnp-9165 190 134 invasive invasive ADJ fnp-9165 190 135 surgical surgical ADJ fnp-9165 190 136 biopsy biopsy NOUN fnp-9165 190 137 ; ; PUNCT fnp-9165 190 138 and and CCONJ fnp-9165 190 139 monitoring monitor VERB fnp-9165 190 140 tumor tumor NOUN fnp-9165 190 141 evolution evolution NOUN fnp-9165 190 142 by by ADP fnp-9165 190 143 serial serial ADJ fnp-9165 190 144 assessments assessment NOUN fnp-9165 190 145 . . PUNCT fnp-9165 191 1 we we PRON fnp-9165 191 2 investigated investigate VERB fnp-9165 191 3 the the DET fnp-9165 191 4 feasibility feasibility NOUN fnp-9165 191 5 and and CCONJ fnp-9165 191 6 utility utility NOUN fnp-9165 191 7 of of ADP fnp-9165 191 8 cerebrospinal cerebrospinal ADJ fnp-9165 191 9 fluid fluid NOUN fnp-9165 191 10 ( ( PUNCT fnp-9165 191 11 csf)-based csf)-base VERB fnp-9165 191 12 lb lb NOUN fnp-9165 191 13 for for ADP fnp-9165 191 14 patients patient NOUN fnp-9165 191 15 with with ADP fnp-9165 191 16 cns cns PROPN fnp-9165 191 17 tumors tumor NOUN fnp-9165 191 18 . . PUNCT fnp-9165 192 1 475 475 NUM fnp-9165 192 2 csf csf ADJ fnp-9165 192 3 samples sample NOUN fnp-9165 192 4 were be AUX fnp-9165 192 5 collected collect VERB fnp-9165 192 6 from from ADP fnp-9165 192 7 patients patient NOUN fnp-9165 192 8 with with ADP fnp-9165 192 9 known known ADJ fnp-9165 192 10 or or CCONJ fnp-9165 192 11 putative putative ADJ fnp-9165 192 12 cns cns NOUN fnp-9165 192 13 tumors tumor NOUN fnp-9165 192 14 . . PUNCT fnp-9165 193 1 to to PART fnp-9165 193 2 detect detect VERB fnp-9165 193 3 circulating circulate VERB fnp-9165 193 4 tumor tumor NOUN fnp-9165 193 5 dna dna NOUN fnp-9165 193 6 ( ( PUNCT fnp-9165 193 7 ctdna ctdna NOUN fnp-9165 193 8 ) ) PUNCT fnp-9165 193 9 , , PUNCT fnp-9165 193 10 cell cell NOUN fnp-9165 193 11 - - PUNCT fnp-9165 193 12 free free ADJ fnp-9165 193 13 dna dna PROPN fnp-9165 193 14 was be AUX fnp-9165 193 15 extracted extract VERB fnp-9165 193 16 and and CCONJ fnp-9165 193 17 panel panel NOUN fnp-9165 193 18 sequencing sequence VERB fnp-9165 193 19 and/or and/or CCONJ fnp-9165 193 20 low low ADJ fnp-9165 193 21 - - PUNCT fnp-9165 193 22 pass pass NOUN fnp-9165 193 23 whole whole ADJ fnp-9165 193 24 genome genome NOUN fnp-9165 193 25 sequencing sequencing NOUN fnp-9165 193 26 were be AUX fnp-9165 193 27 performed perform VERB fnp-9165 193 28 . . PUNCT fnp-9165 194 1 at at ADP fnp-9165 194 2 diagnosis diagnosis NOUN fnp-9165 194 3 / / SYM fnp-9165 194 4 baseline baseline NOUN fnp-9165 194 5 assessment assessment NOUN fnp-9165 194 6 , , PUNCT fnp-9165 194 7 ctdna ctdna PROPN fnp-9165 194 8 was be AUX fnp-9165 194 9 detected detect VERB fnp-9165 194 10 in in ADP fnp-9165 194 11 78 78 NUM fnp-9165 194 12     SPACE fnp-9165 194 13 % % NOUN fnp-9165 194 14 of of ADP fnp-9165 194 15 high high ADJ fnp-9165 194 16 - - PUNCT fnp-9165 194 17 grade grade NOUN fnp-9165 194 18 gliomas glioma NOUN fnp-9165 194 19 , , PUNCT fnp-9165 194 20 44 44 NUM fnp-9165 194 21     SPACE fnp-9165 194 22 % % NOUN fnp-9165 194 23 of of ADP fnp-9165 194 24 low low ADJ fnp-9165 194 25 - - PUNCT fnp-9165 194 26 grade grade NOUN fnp-9165 194 27 gliomas glioma NOUN fnp-9165 194 28 , , PUNCT fnp-9165 194 29 55 55 NUM fnp-9165 194 30     SPACE fnp-9165 194 31 % % NOUN fnp-9165 194 32 of of ADP fnp-9165 194 33 medulloblastomas medulloblastoma NOUN fnp-9165 194 34 and and CCONJ fnp-9165 194 35 93 93 NUM fnp-9165 194 36     SPACE fnp-9165 194 37 % % NOUN fnp-9165 194 38 of of ADP fnp-9165 194 39 germ germ NOUN fnp-9165 194 40 cell cell NOUN fnp-9165 194 41 tumor tumor NOUN fnp-9165 194 42 cases case NOUN fnp-9165 194 43 . . PUNCT fnp-9165 195 1 in in ADP fnp-9165 195 2 patients patient NOUN fnp-9165 195 3 with with ADP fnp-9165 195 4 non non ADJ fnp-9165 195 5 - - ADJ fnp-9165 195 6 biopsied biopsied ADJ fnp-9165 195 7 cns cns NOUN fnp-9165 195 8 lesions lesion NOUN fnp-9165 195 9 , , PUNCT fnp-9165 195 10 ctdna ctdna NOUN fnp-9165 195 11 was be AUX fnp-9165 195 12 diagnostic diagnostic ADJ fnp-9165 195 13 in in ADP fnp-9165 195 14 14 14 NUM fnp-9165 195 15 patients patient NOUN fnp-9165 195 16 including include VERB fnp-9165 195 17 for for ADP fnp-9165 195 18 glioma glioma NOUN fnp-9165 195 19 , , PUNCT fnp-9165 195 20 neuroblastoma neuroblastoma NOUN fnp-9165 195 21 and and CCONJ fnp-9165 195 22 leukemia leukemia NOUN fnp-9165 195 23 . . PUNCT fnp-9165 196 1 furthermore furthermore ADV fnp-9165 196 2 , , PUNCT fnp-9165 196 3 in in ADP fnp-9165 196 4 seven seven NUM fnp-9165 196 5 recurrent recurrent ADJ fnp-9165 196 6 medulloblastoma medulloblastoma NOUN fnp-9165 196 7 cases case NOUN fnp-9165 196 8 where where SCONJ fnp-9165 196 9 primary primary ADJ fnp-9165 196 10 tumor tumor NOUN fnp-9165 196 11 copy copy NOUN fnp-9165 196 12 number number NOUN fnp-9165 196 13 profiles profile NOUN fnp-9165 196 14 were be AUX fnp-9165 196 15 available available ADJ fnp-9165 196 16 , , PUNCT fnp-9165 196 17 new new ADJ fnp-9165 196 18 copy copy NOUN fnp-9165 196 19 number number NOUN fnp-9165 196 20 variants variant NOUN fnp-9165 196 21 suggestive suggestive ADJ fnp-9165 196 22 of of ADP fnp-9165 196 23 tumor tumor NOUN fnp-9165 196 24 evolution evolution NOUN fnp-9165 196 25 / / SYM fnp-9165 196 26 new new ADJ fnp-9165 196 27 subclones subclone NOUN fnp-9165 196 28 were be AUX fnp-9165 196 29 seen see VERB fnp-9165 196 30 . . PUNCT fnp-9165 197 1 in in ADP fnp-9165 197 2 patients patient NOUN fnp-9165 197 3 for for ADP fnp-9165 197 4 whom whom PRON fnp-9165 197 5 serial serial ADJ fnp-9165 197 6 sampling sampling NOUN fnp-9165 197 7 was be AUX fnp-9165 197 8 performed perform VERB fnp-9165 197 9 during during ADP fnp-9165 197 10 and/or and/or CCONJ fnp-9165 197 11 after after ADP fnp-9165 197 12 completion completion NOUN fnp-9165 197 13 of of ADP fnp-9165 197 14 therapy therapy NOUN fnp-9165 197 15 , , PUNCT fnp-9165 197 16 ctdna ctdna NOUN fnp-9165 197 17 clearance clearance NOUN fnp-9165 197 18 was be AUX fnp-9165 197 19 observed observe VERB fnp-9165 197 20 in in ADP fnp-9165 197 21 response response NOUN fnp-9165 197 22 to to ADP fnp-9165 197 23 therapy therapy NOUN fnp-9165 197 24 . . PUNCT fnp-9165 198 1 however however ADV fnp-9165 198 2 , , PUNCT fnp-9165 198 3 persistent persistent ADJ fnp-9165 198 4 ctdna ctdna NOUN fnp-9165 198 5 was be AUX fnp-9165 198 6 observed observe VERB fnp-9165 198 7 in in ADP fnp-9165 198 8 some some DET fnp-9165 198 9 patients patient NOUN fnp-9165 198 10 despite despite SCONJ fnp-9165 198 11 imaging imaging NOUN fnp-9165 198 12 showing show VERB fnp-9165 198 13 no no DET fnp-9165 198 14 residual residual ADJ fnp-9165 198 15 tumor tumor NOUN fnp-9165 198 16 , , PUNCT fnp-9165 198 17 highlighting highlight VERB fnp-9165 198 18 the the DET fnp-9165 198 19 potential potential ADJ fnp-9165 198 20 utility utility NOUN fnp-9165 198 21 of of ADP fnp-9165 198 22 ctdna ctdna NOUN fnp-9165 198 23 as as ADP fnp-9165 198 24 a a DET fnp-9165 198 25 molecular molecular NOUN fnp-9165 198 26 - - PUNCT fnp-9165 198 27 based base VERB fnp-9165 198 28 measurable measurable ADJ fnp-9165 198 29 residual residual ADJ fnp-9165 198 30 disease disease NOUN fnp-9165 198 31 assessment assessment NOUN fnp-9165 198 32 for for ADP fnp-9165 198 33 better well ADJ fnp-9165 198 34 risk risk NOUN fnp-9165 198 35 stratification stratification NOUN fnp-9165 198 36 . . PUNCT fnp-9165 199 1 these these DET fnp-9165 199 2 findings finding NOUN fnp-9165 199 3 pave pave VERB fnp-9165 199 4 the the DET fnp-9165 199 5 way way NOUN fnp-9165 199 6 for for ADP fnp-9165 199 7 the the DET fnp-9165 199 8 clinical clinical ADJ fnp-9165 199 9 use use NOUN fnp-9165 199 10 of of ADP fnp-9165 199 11 lb lb NUM fnp-9165 199 12 in in ADP fnp-9165 199 13 cns cns PROPN fnp-9165 199 14 tumors tumor NOUN fnp-9165 199 15 and and CCONJ fnp-9165 199 16 provide provide VERB fnp-9165 199 17 proof proof NOUN fnp-9165 199 18 of of ADP fnp-9165 199 19 concept concept NOUN fnp-9165 199 20 for for ADP fnp-9165 199 21 future future ADJ fnp-9165 199 22 incorporation incorporation NOUN fnp-9165 199 23 of of ADP fnp-9165 199 24 lb lb NOUN fnp-9165 199 25 into into ADP fnp-9165 199 26 clinical clinical ADJ fnp-9165 199 27 trials trial NOUN fnp-9165 199 28 . . PUNCT fnp-9165 199 29     SPACE fnp-9165 200 1 abstract abstract ADJ fnp-9165 200 2 20 20 NUM fnp-9165 200 3 free free ADJ fnp-9165 200 4 neuropathol neuropathol NOUN fnp-9165 200 5 6:23:25 6:23:25 NUM fnp-9165 200 6 pituitary pituitary ADJ fnp-9165 200 7 inflammatory inflammatory ADJ fnp-9165 200 8 lesions lesion NOUN fnp-9165 200 9 including include VERB fnp-9165 200 10 lymphocytic lymphocytic ADJ fnp-9165 200 11 hypophysitis hypophysitis NOUN fnp-9165 200 12 : : PUNCT fnp-9165 200 13 a a DET fnp-9165 200 14 30 30 NUM fnp-9165 200 15 - - PUNCT fnp-9165 200 16 year year NOUN fnp-9165 200 17 single single ADJ fnp-9165 200 18 centre centre NOUN fnp-9165 200 19 experience experience NOUN fnp-9165 200 20 marc marc PROPN fnp-9165 200 21 r. r. PROPN fnp-9165 200 22 del del PROPN fnp-9165 200 23 bigio1 bigio1 PROPN fnp-9165 200 24 department department PROPN fnp-9165 200 25 of of ADP fnp-9165 200 26 pathology pathology PROPN fnp-9165 200 27 , , PUNCT fnp-9165 200 28 university university PROPN fnp-9165 200 29 of of ADP fnp-9165 200 30 manitoba manitoba PROPN fnp-9165 200 31 and and CCONJ fnp-9165 200 32 shared share VERB fnp-9165 200 33 health health NOUN fnp-9165 200 34 manitoba manitoba PROPN fnp-9165 200 35 , , PUNCT fnp-9165 200 36 winnipeg winnipeg PROPN fnp-9165 200 37 , , PUNCT fnp-9165 200 38 canada canada PROPN fnp-9165 200 39 in in ADP fnp-9165 200 40 manitoba manitoba PROPN fnp-9165 200 41 ( ( PUNCT fnp-9165 200 42 population population NOUN fnp-9165 200 43 1.4 1.4 NUM fnp-9165 200 44 million million NUM fnp-9165 200 45 ) ) PUNCT fnp-9165 200 46 all all DET fnp-9165 200 47 neurosurgical neurosurgical ADJ fnp-9165 200 48 procedures procedure NOUN fnp-9165 200 49 and and CCONJ fnp-9165 200 50 all all DET fnp-9165 200 51 autopsy autopsy ADJ fnp-9165 200 52 neuropathology neuropathology NOUN fnp-9165 200 53 examinations examination NOUN fnp-9165 200 54 are be AUX fnp-9165 200 55 done do VERB fnp-9165 200 56 at at ADP fnp-9165 200 57 one one NUM fnp-9165 200 58 center center NOUN fnp-9165 200 59 . . PUNCT fnp-9165 201 1 in in ADP fnp-9165 201 2 a a DET fnp-9165 201 3 retrospective retrospective ADJ fnp-9165 201 4 review review NOUN fnp-9165 201 5 ( ( PUNCT fnp-9165 201 6 1996–2025 1996–2025 NUM fnp-9165 201 7 ) ) PUNCT fnp-9165 201 8 i i PRON fnp-9165 201 9 searched search VERB fnp-9165 201 10 for for ADP fnp-9165 201 11 cases case NOUN fnp-9165 201 12 with with ADP fnp-9165 201 13 pituitary pituitary ADJ fnp-9165 201 14 inflammation inflammation NOUN fnp-9165 201 15 . . PUNCT fnp-9165 202 1 among among ADP fnp-9165 202 2 678 678 NUM fnp-9165 202 3 surgical surgical ADJ fnp-9165 202 4 pituitary pituitary ADJ fnp-9165 202 5 biopsies biopsy NOUN fnp-9165 202 6 we we PRON fnp-9165 202 7 encountered encounter VERB fnp-9165 202 8 : : PUNCT fnp-9165 202 9 15 15 NUM fnp-9165 202 10 idiopathic idiopathic ADJ fnp-9165 202 11 lymphocytic lymphocytic ADJ fnp-9165 202 12 hypophysitis hypophysitis NOUN fnp-9165 202 13 ; ; PUNCT fnp-9165 202 14 18 18 NUM fnp-9165 202 15 pitnet pitnet NOUN fnp-9165 202 16 with with ADP fnp-9165 202 17 inflammation inflammation NOUN fnp-9165 202 18 ; ; PUNCT fnp-9165 202 19 34 34 NUM fnp-9165 202 20 pitnet pitnet NOUN fnp-9165 202 21 + + CCONJ fnp-9165 202 22 apoplexy apoplexy NOUN fnp-9165 202 23 with with ADP fnp-9165 202 24 inflammation inflammation NOUN fnp-9165 202 25 ; ; PUNCT fnp-9165 202 26 13 13 NUM fnp-9165 202 27 inflammation inflammation NOUN fnp-9165 202 28 associated associate VERB fnp-9165 202 29 with with ADP fnp-9165 202 30 rathke rathke NOUN fnp-9165 202 31 cleft cleft NOUN fnp-9165 202 32 cyst cyst NOUN fnp-9165 202 33 ; ; PUNCT fnp-9165 202 34 3 3 NUM fnp-9165 202 35 bacterial bacterial ADJ fnp-9165 202 36 infection infection NOUN fnp-9165 202 37 . . PUNCT fnp-9165 203 1 among among ADP fnp-9165 203 2 4768 4768 NUM fnp-9165 203 3 pituitaries pituitary NOUN fnp-9165 203 4 from from ADP fnp-9165 203 5 autopsies autopsy NOUN fnp-9165 203 6 we we PRON fnp-9165 203 7 encountered encounter VERB fnp-9165 203 8 : : PUNCT fnp-9165 203 9 16 16 NUM fnp-9165 203 10 idiopathic idiopathic ADJ fnp-9165 203 11 lymphocytic lymphocytic ADJ fnp-9165 203 12 hypophysitis hypophysitis NOUN fnp-9165 203 13 ; ; PUNCT fnp-9165 203 14 1 1 NUM fnp-9165 203 15 pitnet pitnet NOUN fnp-9165 203 16 + + CCONJ fnp-9165 203 17 apoplexy apoplexy ADJ fnp-9165 203 18 ; ; PUNCT fnp-9165 203 19 2 2 NUM fnp-9165 203 20 pituitary pituitary ADJ fnp-9165 203 21 apoplexy apoplexy NOUN fnp-9165 203 22 without without ADP fnp-9165 203 23 obvious obvious ADJ fnp-9165 203 24 cause cause NOUN fnp-9165 203 25 ; ; PUNCT fnp-9165 203 26 3 3 NUM fnp-9165 203 27 inflammation inflammation NOUN fnp-9165 203 28 associated associate VERB fnp-9165 203 29 with with ADP fnp-9165 203 30 rathke rathke NOUN fnp-9165 203 31 cleft cleft NOUN fnp-9165 203 32 cyst cyst NOUN fnp-9165 203 33 ; ; PUNCT fnp-9165 203 34 19 19 NUM fnp-9165 203 35 pituitary pituitary ADJ fnp-9165 203 36 inflammation inflammation NOUN fnp-9165 203 37 and and CCONJ fnp-9165 203 38 associated associate VERB fnp-9165 203 39 disseminated disseminate VERB fnp-9165 203 40 infection infection NOUN fnp-9165 203 41 ( ( PUNCT fnp-9165 203 42 2 2 NUM fnp-9165 203 43 herpes herpe NOUN fnp-9165 203 44 simplex simplex NOUN fnp-9165 203 45 ; ; PUNCT fnp-9165 203 46 5 5 NUM fnp-9165 203 47 suspected suspect VERB fnp-9165 203 48 viral viral ADJ fnp-9165 203 49 ; ; PUNCT fnp-9165 203 50 5 5 NUM fnp-9165 203 51 mycobacterial mycobacterial ADJ fnp-9165 203 52 ; ; PUNCT fnp-9165 203 53 7 7 NUM fnp-9165 203 54 other other ADJ fnp-9165 203 55 bacterial bacterial ADJ fnp-9165 203 56 sepsis sepsis NOUN fnp-9165 203 57 / / SYM fnp-9165 203 58 meningitis meningitis NOUN fnp-9165 203 59 ) ) PUNCT fnp-9165 203 60 . . PUNCT fnp-9165 204 1 in in ADP fnp-9165 204 2 some some DET fnp-9165 204 3 autopsy autopsy ADJ fnp-9165 204 4 cases case NOUN fnp-9165 204 5 lymphocytic lymphocytic ADJ fnp-9165 204 6 hypophysitis hypophysitis NOUN fnp-9165 204 7 was be AUX fnp-9165 204 8 incidental incidental ADJ fnp-9165 204 9 , , PUNCT fnp-9165 204 10 1 1 NUM fnp-9165 204 11 had have VERB fnp-9165 204 12 chronic chronic ADJ fnp-9165 204 13 demyelinating demyelinate VERB fnp-9165 204 14 disease disease NOUN fnp-9165 204 15 , , PUNCT fnp-9165 204 16 4 4 NUM fnp-9165 204 17 had have VERB fnp-9165 204 18 prominent prominent ADJ fnp-9165 204 19 inflammation inflammation NOUN fnp-9165 204 20 in in ADP fnp-9165 204 21 the the DET fnp-9165 204 22 thyroid thyroid NOUN fnp-9165 204 23 , , PUNCT fnp-9165 204 24 and and CCONJ fnp-9165 204 25 in in ADP fnp-9165 204 26 1 1 NUM fnp-9165 204 27 case case NOUN fnp-9165 204 28 it it PRON fnp-9165 204 29 was be AUX fnp-9165 204 30 considered consider VERB fnp-9165 204 31 to to PART fnp-9165 204 32 be be AUX fnp-9165 204 33 a a DET fnp-9165 204 34 major major ADJ fnp-9165 204 35 contributor contributor NOUN fnp-9165 204 36 to to ADP fnp-9165 204 37 death death NOUN fnp-9165 204 38 . . PUNCT fnp-9165 205 1 four four NUM fnp-9165 205 2 decedents decedent NOUN fnp-9165 205 3 had have VERB fnp-9165 205 4 pre pre ADJ fnp-9165 205 5 - - ADJ fnp-9165 205 6 mortem mortem ADJ fnp-9165 205 7 clinical clinical ADJ fnp-9165 205 8 endocrine endocrine NOUN fnp-9165 205 9 syndrome syndrome NOUN fnp-9165 205 10 ( ( PUNCT fnp-9165 205 11 38 38 NUM fnp-9165 205 12 - - PUNCT fnp-9165 205 13 year year NOUN fnp-9165 205 14 female female ADJ fnp-9165 205 15 hypothyroidism hypothyroidism NOUN fnp-9165 205 16 ; ; PUNCT fnp-9165 205 17 49 49 NUM fnp-9165 205 18 - - PUNCT fnp-9165 205 19 year year NOUN fnp-9165 205 20 female female ADJ fnp-9165 205 21 hyperprolactinemia hyperprolactinemia NOUN fnp-9165 205 22 ; ; PUNCT fnp-9165 205 23 44 44 NUM fnp-9165 205 24 - - PUNCT fnp-9165 205 25 year year NOUN fnp-9165 205 26 male male NOUN fnp-9165 205 27 addison addison PROPN fnp-9165 205 28 disease disease NOUN fnp-9165 205 29 and and CCONJ fnp-9165 205 30 hypothyroidism hypothyroidism NOUN fnp-9165 205 31 ; ; PUNCT fnp-9165 205 32 49 49 NUM fnp-9165 205 33 - - PUNCT fnp-9165 205 34 year year NOUN fnp-9165 205 35 female female ADJ fnp-9165 205 36 diabetes diabetes NOUN fnp-9165 205 37 mellitus mellitus NOUN fnp-9165 205 38 ) ) PUNCT fnp-9165 205 39 . . PUNCT fnp-9165 206 1 conclusive conclusive ADJ fnp-9165 206 2 proof proof NOUN fnp-9165 206 3 of of ADP fnp-9165 206 4 autoimmune autoimmune ADJ fnp-9165 206 5 lymphocytic lymphocytic ADJ fnp-9165 206 6 hypophysitis hypophysitis NOUN fnp-9165 206 7 is be AUX fnp-9165 206 8 elusive elusive ADJ fnp-9165 206 9 . . PUNCT fnp-9165 207 1 pitnet pitnet NOUN fnp-9165 207 2 , , PUNCT fnp-9165 207 3 apoplexy apoplexy ADJ fnp-9165 207 4 , , PUNCT fnp-9165 207 5 and and CCONJ fnp-9165 207 6 cyst cyst NOUN fnp-9165 207 7 - - PUNCT fnp-9165 207 8 associated associate VERB fnp-9165 207 9 inflammation inflammation NOUN fnp-9165 207 10 are be AUX fnp-9165 207 11 common common ADJ fnp-9165 207 12 and and CCONJ fnp-9165 207 13 of of ADP fnp-9165 207 14 uncertain uncertain ADJ fnp-9165 207 15 significance significance NOUN fnp-9165 207 16 . . PUNCT fnp-9165 208 1 in in ADP fnp-9165 208 2 all all DET fnp-9165 208 3 specimens specimen NOUN fnp-9165 208 4 , , PUNCT fnp-9165 208 5 complete complete ADJ fnp-9165 208 6 history history NOUN fnp-9165 208 7 and and CCONJ fnp-9165 208 8 imaging imaging NOUN fnp-9165 208 9 correlates correlate NOUN fnp-9165 208 10 are be AUX fnp-9165 208 11 necessary necessary ADJ fnp-9165 208 12 . . PUNCT fnp-9165 209 1 although although SCONJ fnp-9165 209 2 rarely rarely ADV fnp-9165 209 3 a a DET fnp-9165 209 4 contributor contributor NOUN fnp-9165 209 5 to to ADP fnp-9165 209 6 death death NOUN fnp-9165 209 7 , , PUNCT fnp-9165 209 8 examination examination NOUN fnp-9165 209 9 of of ADP fnp-9165 209 10 the the DET fnp-9165 209 11 pituitary pituitary ADJ fnp-9165 209 12 gland gland NOUN fnp-9165 209 13 is be AUX fnp-9165 209 14 an an DET fnp-9165 209 15 important important ADJ fnp-9165 209 16 part part NOUN fnp-9165 209 17 of of ADP fnp-9165 209 18 the the DET fnp-9165 209 19 autopsy autopsy NOUN fnp-9165 209 20 in in ADP fnp-9165 209 21 individuals individual NOUN fnp-9165 209 22 who who PRON fnp-9165 209 23 die die VERB fnp-9165 209 24 unexpectedly unexpectedly ADV fnp-9165 209 25 , , PUNCT fnp-9165 209 26 particularly particularly ADV fnp-9165 209 27 if if SCONJ fnp-9165 209 28 they they PRON fnp-9165 209 29 have have VERB fnp-9165 209 30 a a DET fnp-9165 209 31 history history NOUN fnp-9165 209 32 of of ADP fnp-9165 209 33 endocrine endocrine ADJ fnp-9165 209 34 disease disease NOUN fnp-9165 209 35 or or CCONJ fnp-9165 209 36 recent recent ADJ fnp-9165 209 37 neurological neurological ADJ fnp-9165 209 38 symptoms symptom NOUN fnp-9165 209 39 . . PUNCT fnp-9165 209 40     SPACE fnp-9165 209 41 abstract abstract ADJ fnp-9165 209 42 21 21 NUM fnp-9165 209 43 free free ADJ fnp-9165 209 44 neuropathol neuropathol NOUN fnp-9165 209 45 6:23:26 6:23:26 NUM fnp-9165 209 46 additional additional ADJ fnp-9165 209 47 presence presence NOUN fnp-9165 209 48 of of ADP fnp-9165 209 49 lztr1 lztr1 PROPN fnp-9165 209 50 mutation mutation NOUN fnp-9165 209 51 in in ADP fnp-9165 209 52 a a DET fnp-9165 209 53 vgll vgll ADV fnp-9165 209 54 - - PUNCT fnp-9165 209 55 fused fuse VERB fnp-9165 209 56 central central ADJ fnp-9165 209 57 nervous nervous ADJ fnp-9165 209 58 system system NOUN fnp-9165 209 59 schwannoma schwannoma ADJ fnp-9165 209 60 with with ADP fnp-9165 209 61 neuroblastoma neuroblastoma NOUN fnp-9165 209 62 - - PUNCT fnp-9165 209 63 like like ADJ fnp-9165 209 64 cell cell NOUN fnp-9165 209 65 dense dense ADJ fnp-9165 209 66 areas area NOUN fnp-9165 209 67 david david PROPN fnp-9165 209 68 g. g. PROPN fnp-9165 209 69 munoz1 munoz1 PROPN fnp-9165 209 70 , , PUNCT fnp-9165 209 71 sunit sunit ADJ fnp-9165 209 72 das2 das2 PROPN fnp-9165 209 73 , , PUNCT fnp-9165 209 74 ju ju PROPN fnp-9165 209 75 - - PROPN fnp-9165 209 76 yoon yoon PROPN fnp-9165 209 77 yoon1 yoon1 PROPN fnp-9165 209 78 , , PUNCT fnp-9165 209 79 robert robert PROPN fnp-9165 209 80 siddaway3 siddaway3 PROPN fnp-9165 209 81 , , PUNCT fnp-9165 209 82 adrian adrian PROPN fnp-9165 209 83 levine3 levine3 PROPN fnp-9165 209 84 , , PUNCT fnp-9165 209 85 kenneth kenneth PROPN fnp-9165 209 86 d. d. PROPN fnp-9165 209 87 aldape4 aldape4 PROPN fnp-9165 210 1 laboratory laboratory NOUN fnp-9165 210 2 medicine medicine NOUN fnp-9165 210 3 and and CCONJ fnp-9165 210 4 pathobiology pathobiology NOUN fnp-9165 210 5 , , PUNCT fnp-9165 210 6 university university PROPN fnp-9165 210 7 of of ADP fnp-9165 210 8 toronto toronto PROPN fnp-9165 210 9 ; ; PUNCT fnp-9165 210 10 department department NOUN fnp-9165 210 11 of of ADP fnp-9165 210 12 laboratory laboratory NOUN fnp-9165 210 13 medicine medicine NOUN fnp-9165 210 14 , , PUNCT fnp-9165 210 15 unity unity NOUN fnp-9165 210 16 health health PROPN fnp-9165 210 17 toronto toronto PROPN fnp-9165 210 18 , , PUNCT fnp-9165 210 19 toronto toronto PROPN fnp-9165 210 20 , , PUNCT fnp-9165 210 21 canada canada PROPN fnp-9165 210 22 department department PROPN fnp-9165 210 23 of of ADP fnp-9165 210 24 surgery surgery NOUN fnp-9165 210 25 , , PUNCT fnp-9165 210 26 division division NOUN fnp-9165 210 27 of of ADP fnp-9165 210 28 neurosurgery neurosurgery NOUN fnp-9165 210 29 , , PUNCT fnp-9165 210 30 unity unity NOUN fnp-9165 210 31 health health PROPN fnp-9165 210 32 toronto toronto PROPN fnp-9165 210 33 , , PUNCT fnp-9165 210 34 toronto toronto PROPN fnp-9165 210 35 , , PUNCT fnp-9165 210 36 canada canada PROPN fnp-9165 210 37 department department PROPN fnp-9165 210 38 of of ADP fnp-9165 210 39 laboratory laboratory NOUN fnp-9165 210 40 medicine medicine NOUN fnp-9165 210 41 , , PUNCT fnp-9165 210 42 hospital hospital NOUN fnp-9165 210 43 for for ADP fnp-9165 210 44 sick sick ADJ fnp-9165 210 45 children child NOUN fnp-9165 210 46 , , PUNCT fnp-9165 210 47 toronto toronto PROPN fnp-9165 210 48 , , PUNCT fnp-9165 210 49 canada canada PROPN fnp-9165 210 50 laboratory laboratory PROPN fnp-9165 210 51 of of ADP fnp-9165 210 52 pathology pathology PROPN fnp-9165 210 53 , , PUNCT fnp-9165 210 54 center center NOUN fnp-9165 210 55 for for ADP fnp-9165 210 56 cancer cancer NOUN fnp-9165 210 57 research research NOUN fnp-9165 210 58 , , PUNCT fnp-9165 210 59 national national PROPN fnp-9165 210 60 cancer cancer PROPN fnp-9165 210 61 institute institute PROPN fnp-9165 210 62 , , PUNCT fnp-9165 210 63 national national PROPN fnp-9165 210 64 institutes institutes PROPN fnp-9165 210 65 of of ADP fnp-9165 210 66 health health NOUN fnp-9165 210 67 , , PUNCT fnp-9165 210 68 bethesda bethesda NOUN fnp-9165 210 69 , , PUNCT fnp-9165 210 70 maryland maryland PROPN fnp-9165 210 71 , , PUNCT fnp-9165 210 72 usa usa PROPN fnp-9165 210 73 vestigial vestigial ADJ fnp-9165 210 74 - - PUNCT fnp-9165 210 75 like like ADJ fnp-9165 210 76 family family NOUN fnp-9165 210 77 ( ( PUNCT fnp-9165 210 78 vgll vgll ADV fnp-9165 210 79 ) ) PUNCT fnp-9165 210 80 altered alter VERB fnp-9165 210 81 cns cns PROPN fnp-9165 210 82 schwannoma schwannoma PROPN fnp-9165 210 83 ( ( PUNCT fnp-9165 210 84 vgllacs vgllac NOUN fnp-9165 210 85 ) ) PUNCT fnp-9165 210 86 is be AUX fnp-9165 210 87 a a DET fnp-9165 210 88 new new ADJ fnp-9165 210 89 tumor tumor NOUN fnp-9165 210 90 entity entity NOUN fnp-9165 210 91 , , PUNCT fnp-9165 210 92 recognizable recognizable ADJ fnp-9165 210 93 by by ADP fnp-9165 210 94 dna dna PROPN fnp-9165 210 95 methylation methylation NOUN fnp-9165 210 96 approaches approach NOUN fnp-9165 210 97 . . PUNCT fnp-9165 211 1 the the DET fnp-9165 211 2 critical critical ADJ fnp-9165 211 3 alteration alteration NOUN fnp-9165 211 4 is be AUX fnp-9165 211 5 a a DET fnp-9165 211 6 fusion fusion NOUN fnp-9165 211 7 , , PUNCT fnp-9165 211 8 involving involve VERB fnp-9165 211 9 either either CCONJ fnp-9165 211 10 vgll1 vgll1 NOUN fnp-9165 211 11 or or CCONJ fnp-9165 211 12 vgll3 vgll3 NOUN fnp-9165 211 13 . . PUNCT fnp-9165 212 1 the the DET fnp-9165 212 2 fusion fusion NOUN fnp-9165 212 3 partner partner NOUN fnp-9165 212 4 can can AUX fnp-9165 212 5 be be AUX fnp-9165 212 6 ewsr1 ewsr1 PROPN fnp-9165 212 7 , , PUNCT fnp-9165 212 8 chd7 chd7 NOUN fnp-9165 212 9 , , PUNCT fnp-9165 212 10 and and CCONJ fnp-9165 212 11 rarely rarely ADV fnp-9165 212 12 ss18 ss18 PROPN fnp-9165 212 13 . . PUNCT fnp-9165 213 1 a a DET fnp-9165 213 2 recent recent ADJ fnp-9165 213 3 series series NOUN fnp-9165 213 4 of of ADP fnp-9165 213 5 20 20 NUM fnp-9165 213 6 vgllacs vgllac NOUN fnp-9165 213 7 did do AUX fnp-9165 213 8 not not PART fnp-9165 213 9 identify identify VERB fnp-9165 213 10 additional additional ADJ fnp-9165 213 11 recurrent recurrent ADJ fnp-9165 213 12 mutations mutation NOUN fnp-9165 213 13 . . PUNCT fnp-9165 214 1 to to PART fnp-9165 214 2 add add VERB fnp-9165 214 3 to to ADP fnp-9165 214 4 the the DET fnp-9165 214 5 span span NOUN fnp-9165 214 6 of of ADP fnp-9165 214 7 the the DET fnp-9165 214 8 condition condition NOUN fnp-9165 214 9 , , PUNCT fnp-9165 214 10 we we PRON fnp-9165 214 11 report report VERB fnp-9165 214 12 a a DET fnp-9165 214 13 previously previously ADV fnp-9165 214 14 healthy healthy ADJ fnp-9165 214 15 29 29 NUM fnp-9165 214 16 - - PUNCT fnp-9165 214 17 year year NOUN fnp-9165 214 18 - - PUNCT fnp-9165 214 19 old old ADJ fnp-9165 214 20 man man NOUN fnp-9165 214 21 who who PRON fnp-9165 214 22 presented present VERB fnp-9165 214 23 with with ADP fnp-9165 214 24 a a DET fnp-9165 214 25 clonic clonic ADJ fnp-9165 214 26 seizure seizure NOUN fnp-9165 214 27 . . PUNCT fnp-9165 215 1 head head NOUN fnp-9165 215 2 mri mri NOUN fnp-9165 215 3 showed show VERB fnp-9165 215 4 an an DET fnp-9165 215 5 avidly avidly ADV fnp-9165 215 6 enhancing enhance VERB fnp-9165 215 7 well well ADV fnp-9165 215 8 - - PUNCT fnp-9165 215 9 demarcated demarcate VERB fnp-9165 215 10 intra intra ADJ fnp-9165 215 11 - - ADJ fnp-9165 215 12 axial axial ADJ fnp-9165 215 13 nodule nodule NOUN fnp-9165 215 14 in in ADP fnp-9165 215 15 the the DET fnp-9165 215 16 left left ADJ fnp-9165 215 17 superior superior ADJ fnp-9165 215 18 frontal frontal ADJ fnp-9165 215 19 gyrus gyrus NOUN fnp-9165 215 20 extending extend VERB fnp-9165 215 21 to to ADP fnp-9165 215 22 cortex cortex NOUN fnp-9165 215 23 . . PUNCT fnp-9165 216 1 at at ADP fnp-9165 216 2 surgery surgery NOUN fnp-9165 216 3 the the DET fnp-9165 216 4 intra intra ADJ fnp-9165 216 5 - - ADJ fnp-9165 216 6 axial axial ADJ fnp-9165 216 7 firm firm ADJ fnp-9165 216 8 mass mass NOUN fnp-9165 216 9 , , PUNCT fnp-9165 216 10 well well ADV fnp-9165 216 11 - - PUNCT fnp-9165 216 12 demarcated demarcate VERB fnp-9165 216 13 from from ADP fnp-9165 216 14 the the DET fnp-9165 216 15 brain brain NOUN fnp-9165 216 16 , , PUNCT fnp-9165 216 17 was be AUX fnp-9165 216 18 completely completely ADV fnp-9165 216 19 resected resect VERB fnp-9165 216 20 . . PUNCT fnp-9165 217 1 histologically histologically ADV fnp-9165 217 2 , , PUNCT fnp-9165 217 3 most most ADJ fnp-9165 217 4 of of ADP fnp-9165 217 5 the the DET fnp-9165 217 6 tumor tumor NOUN fnp-9165 217 7 consisted consist VERB fnp-9165 217 8 of of ADP fnp-9165 217 9 spindle spindle NOUN fnp-9165 217 10 cells cell NOUN fnp-9165 217 11 arranged arrange VERB fnp-9165 217 12 in in ADP fnp-9165 217 13 streams stream NOUN fnp-9165 217 14 organized organize VERB fnp-9165 217 15 in in ADP fnp-9165 217 16 rhythmic rhythmic ADJ fnp-9165 217 17 palisades palisade NOUN fnp-9165 217 18 in in ADP fnp-9165 217 19 a a DET fnp-9165 217 20 collagenous collagenous ADJ fnp-9165 217 21 background background NOUN fnp-9165 217 22 . . PUNCT fnp-9165 218 1 in in ADP fnp-9165 218 2 addition addition NOUN fnp-9165 218 3 , , PUNCT fnp-9165 218 4 there there PRON fnp-9165 218 5 was be VERB fnp-9165 218 6 a a DET fnp-9165 218 7 peripheral peripheral ADJ fnp-9165 218 8 nodule nodule NOUN fnp-9165 218 9 made make VERB fnp-9165 218 10 up up ADP fnp-9165 218 11 of of ADP fnp-9165 218 12 densely densely ADV fnp-9165 218 13 packed pack VERB fnp-9165 218 14 neuroblastoma neuroblastoma NOUN fnp-9165 218 15 - - PUNCT fnp-9165 218 16 like like ADJ fnp-9165 218 17 cells cell NOUN fnp-9165 218 18 . . PUNCT fnp-9165 219 1 both both DET fnp-9165 219 2 areas area NOUN fnp-9165 219 3 showed show VERB fnp-9165 219 4 gfap gfap ADJ fnp-9165 219 5 expression expression NOUN fnp-9165 219 6 , , PUNCT fnp-9165 219 7 and and CCONJ fnp-9165 219 8 reticulin reticulin ADJ fnp-9165 219 9 single single ADJ fnp-9165 219 10 cell cell NOUN fnp-9165 219 11 wrapping wrapping NOUN fnp-9165 219 12 . . PUNCT fnp-9165 220 1 at at ADP fnp-9165 220 2 the the DET fnp-9165 220 3 periphery periphery NOUN fnp-9165 220 4 the the DET fnp-9165 220 5 tumor tumor NOUN fnp-9165 220 6 was be AUX fnp-9165 220 7 interspersed intersperse VERB fnp-9165 220 8 with with ADP fnp-9165 220 9 synaptophysin synaptophysin NOUN fnp-9165 220 10 - - PUNCT fnp-9165 220 11 rich rich ADJ fnp-9165 220 12 neuropil neuropil NOUN fnp-9165 220 13 , , PUNCT fnp-9165 220 14 and and CCONJ fnp-9165 220 15 rosenthal rosenthal NOUN fnp-9165 220 16 fibers fiber NOUN fnp-9165 220 17 were be AUX fnp-9165 220 18 present present ADJ fnp-9165 220 19 within within ADP fnp-9165 220 20 the the DET fnp-9165 220 21 tumor tumor NOUN fnp-9165 220 22 . . PUNCT fnp-9165 221 1 a a DET fnp-9165 221 2 methylation methylation NOUN fnp-9165 221 3 profile profile NOUN fnp-9165 221 4 analysis analysis NOUN fnp-9165 221 5 carried carry VERB fnp-9165 221 6 out out ADP fnp-9165 221 7 at at ADP fnp-9165 221 8 the the DET fnp-9165 221 9 national national PROPN fnp-9165 221 10 cancer cancer PROPN fnp-9165 221 11 institute institute PROPN fnp-9165 221 12 matched match VERB fnp-9165 221 13 to to ADP fnp-9165 221 14 cns cns PROPN fnp-9165 221 15 schwannoma schwannoma ADJ fnp-9165 221 16 vgll vgll ADV fnp-9165 221 17 - - PUNCT fnp-9165 221 18 fused fuse VERB fnp-9165 221 19 . . PUNCT fnp-9165 222 1 trusight trusight VERB fnp-9165 222 2 pancancer pancancer NOUN fnp-9165 222 3 next next ADJ fnp-9165 222 4 generation generation NOUN fnp-9165 222 5 sequencing sequence VERB fnp-9165 222 6 ( ( PUNCT fnp-9165 222 7 ngs ng NOUN fnp-9165 222 8 ) ) PUNCT fnp-9165 222 9 revealed reveal VERB fnp-9165 222 10 a a DET fnp-9165 222 11 ewsr1::vgll1 ewsr1::vgll1 ADJ fnp-9165 222 12 fusion fusion NOUN fnp-9165 222 13 , , PUNCT fnp-9165 222 14 specifically specifically ADV fnp-9165 222 15 ewsr1 ewsr1 NOUN fnp-9165 222 16 nm_013986 nm_013986 PROPN fnp-9165 222 17 ( ( PUNCT fnp-9165 222 18 exon exon NOUN fnp-9165 222 19 9 9 NUM fnp-9165 222 20 , , PUNCT fnp-9165 222 21 331 331 NUM fnp-9165 222 22 aa aa NOUN fnp-9165 222 23 ) ) PUNCT fnp-9165 222 24 to to PART fnp-9165 222 25 vgll1 vgll1 VERB fnp-9165 222 26 nm_016267 nm_016267 ADV fnp-9165 222 27 ( ( PUNCT fnp-9165 222 28 5 5 NUM fnp-9165 222 29 ’ ' PUNCT fnp-9165 222 30 utr utr NOUN fnp-9165 222 31 , , PUNCT fnp-9165 222 32 exon exon NOUN fnp-9165 222 33 2 2 NUM fnp-9165 222 34 ) ) PUNCT fnp-9165 222 35 . . PUNCT fnp-9165 223 1 a a DET fnp-9165 223 2 tier tier NOUN fnp-9165 223 3 ii ii NOUN fnp-9165 223 4 mutation mutation NOUN fnp-9165 223 5 in in ADP fnp-9165 223 6 lztr1 lztr1 PROPN fnp-9165 223 7 ( ( PUNCT fnp-9165 223 8 p.trp265*nm_006767.4 p.trp265*nm_006767.4 PROPN fnp-9165 223 9 : : PUNCT fnp-9165 223 10 c.794g c.794g VERB fnp-9165 223 11 > > NOUN fnp-9165 223 12 a a PRON fnp-9165 223 13 ) ) PUNCT fnp-9165 223 14 was be AUX fnp-9165 223 15 identified identify VERB fnp-9165 223 16 by by ADP fnp-9165 223 17 hybridization hybridization NOUN fnp-9165 223 18 - - PUNCT fnp-9165 223 19 capture capture NOUN fnp-9165 223 20 ngs ng NOUN fnp-9165 223 21 assay assay VERB fnp-9165 223 22 . . PUNCT fnp-9165 224 1 our our PRON fnp-9165 224 2 case case NOUN fnp-9165 224 3 represents represent VERB fnp-9165 224 4 another another DET fnp-9165 224 5 rare rare ADJ fnp-9165 224 6 case case NOUN fnp-9165 224 7 of of ADP fnp-9165 224 8 vgllacs vgllac NOUN fnp-9165 224 9 with with ADP fnp-9165 224 10 neuroblastoma neuroblastoma NOUN fnp-9165 224 11 - - PUNCT fnp-9165 224 12 like like ADJ fnp-9165 224 13 areas area NOUN fnp-9165 224 14 in in ADP fnp-9165 224 15 association association NOUN fnp-9165 224 16 with with ADP fnp-9165 224 17 an an DET fnp-9165 224 18 additional additional ADJ fnp-9165 224 19 mutation mutation NOUN fnp-9165 224 20 in in ADP fnp-9165 224 21 lztr1 lztr1 PROPN fnp-9165 224 22 , , PUNCT fnp-9165 224 23 a a DET fnp-9165 224 24 gene gene NOUN fnp-9165 224 25 mutated mutate VERB fnp-9165 224 26 in in ADP fnp-9165 224 27 both both DET fnp-9165 224 28 schwannosis schwannosis NOUN fnp-9165 224 29 and and CCONJ fnp-9165 224 30 glioblastoma glioblastoma NOUN fnp-9165 224 31 . . PUNCT fnp-9165 224 32     SPACE fnp-9165 225 1 abstract abstract ADJ fnp-9165 225 2 22 22 NUM fnp-9165 225 3 free free ADJ fnp-9165 225 4 neuropathol neuropathol NOUN fnp-9165 225 5 6:23:27 6:23:27 NUM fnp-9165 225 6 histopathological histopathological ADJ fnp-9165 225 7 and and CCONJ fnp-9165 225 8 clinical clinical ADJ fnp-9165 225 9 features feature NOUN fnp-9165 225 10 can can AUX fnp-9165 225 11 discriminate discriminate VERB fnp-9165 225 12 immune immune ADJ fnp-9165 225 13 from from ADP fnp-9165 225 14 non non ADJ fnp-9165 225 15 - - ADJ fnp-9165 225 16 immune immune ADJ fnp-9165 225 17 statin statin NOUN fnp-9165 225 18 - - PUNCT fnp-9165 225 19 induced induce VERB fnp-9165 225 20 myotoxicity myotoxicity NOUN fnp-9165 225 21 benjamin benjamin PROPN fnp-9165 225 22 ellezam1 ellezam1 PROPN fnp-9165 225 23 , , PUNCT fnp-9165 225 24 yves yve NOUN fnp-9165 225 25 troyanov2 troyanov2 PROPN fnp-9165 225 26 , , PUNCT fnp-9165 225 27 océane océane ADJ fnp-9165 225 28 landon landon ADJ fnp-9165 225 29 - - PUNCT fnp-9165 225 30 cardinal3 cardinal3 NOUN fnp-9165 225 31 division division NOUN fnp-9165 225 32 of of ADP fnp-9165 225 33 pathology pathology PROPN fnp-9165 225 34 , , PUNCT fnp-9165 225 35 chu chu PROPN fnp-9165 225 36 sainte sainte PROPN fnp-9165 225 37 - - PUNCT fnp-9165 225 38 justine justine PROPN fnp-9165 225 39 , , PUNCT fnp-9165 225 40 montréal montréal PROPN fnp-9165 225 41 , , PUNCT fnp-9165 225 42 canada canada PROPN fnp-9165 225 43 division division NOUN fnp-9165 225 44 of of ADP fnp-9165 225 45 rheumatology rheumatology NOUN fnp-9165 225 46 , , PUNCT fnp-9165 225 47 hôpital hôpital PROPN fnp-9165 225 48 du du PROPN fnp-9165 225 49 sacré sacré PROPN fnp-9165 225 50 - - PUNCT fnp-9165 225 51 cœur cœur NOUN fnp-9165 225 52 , , PUNCT fnp-9165 225 53 montréal montréal PROPN fnp-9165 225 54 , , PUNCT fnp-9165 225 55 canada canada PROPN fnp-9165 225 56 division division NOUN fnp-9165 225 57 of of ADP fnp-9165 225 58 rheumatology rheumatology NOUN fnp-9165 225 59 , , PUNCT fnp-9165 225 60 centre centre NOUN fnp-9165 225 61 hospitalier hospitalier X fnp-9165 225 62 de de X fnp-9165 225 63 l'université l'université X fnp-9165 225 64 de de X fnp-9165 225 65 montréal montréal PROPN fnp-9165 225 66 ; ; PUNCT fnp-9165 225 67 université université PROPN fnp-9165 225 68 de de PROPN fnp-9165 225 69 montréal montréal PROPN fnp-9165 225 70 , , PUNCT fnp-9165 225 71 montréal montréal PROPN fnp-9165 225 72 , , PUNCT fnp-9165 225 73 canda canda PROPN fnp-9165 225 74 anti anti ADJ fnp-9165 225 75 - - ADJ fnp-9165 225 76 hmgcr hmgcr ADJ fnp-9165 225 77 immune immune NOUN fnp-9165 225 78 - - PUNCT fnp-9165 225 79 mediated mediate VERB fnp-9165 225 80 necrotizing necrotizing NOUN fnp-9165 225 81 myopathy myopathy NOUN fnp-9165 225 82 ( ( PUNCT fnp-9165 225 83 imnm imnm PROPN fnp-9165 225 84 ) ) PUNCT fnp-9165 225 85 is be AUX fnp-9165 225 86 a a DET fnp-9165 225 87 subacute subacute NOUN fnp-9165 225 88 to to ADP fnp-9165 225 89 chronic chronic ADJ fnp-9165 225 90 progressive progressive ADJ fnp-9165 225 91 auto auto NOUN fnp-9165 225 92 - - PUNCT fnp-9165 225 93 immune immune NOUN fnp-9165 225 94 myositis myositis NOUN fnp-9165 225 95 diagnosed diagnose VERB fnp-9165 225 96 on on ADP fnp-9165 225 97 clinical clinical ADJ fnp-9165 225 98 phenotype phenotype NOUN fnp-9165 225 99 , , PUNCT fnp-9165 225 100 serology serology NOUN fnp-9165 225 101 and and CCONJ fnp-9165 225 102 muscle muscle NOUN fnp-9165 225 103 biopsy biopsy NOUN fnp-9165 225 104 , , PUNCT fnp-9165 225 105 and and CCONJ fnp-9165 225 106 non non ADJ fnp-9165 225 107 - - ADJ fnp-9165 225 108 immune immune ADJ fnp-9165 225 109 toxic toxic ADJ fnp-9165 225 110 rhabdomyolysis rhabdomyolysis NOUN fnp-9165 225 111 ( ( PUNCT fnp-9165 226 1 tr tr VERB fnp-9165 226 2 ) ) PUNCT fnp-9165 226 3 is be AUX fnp-9165 226 4 an an DET fnp-9165 226 5 acute acute ADJ fnp-9165 226 6 potentially potentially ADV fnp-9165 226 7 lethal lethal ADJ fnp-9165 226 8 condition condition NOUN fnp-9165 226 9 usually usually ADV fnp-9165 226 10 diagnosed diagnose VERB fnp-9165 226 11 on on ADP fnp-9165 226 12 clinical clinical ADJ fnp-9165 226 13 phenotype phenotype NOUN fnp-9165 226 14 alone alone ADV fnp-9165 226 15 . . PUNCT fnp-9165 227 1 however however ADV fnp-9165 227 2 , , PUNCT fnp-9165 227 3 muscle muscle NOUN fnp-9165 227 4 biopsies biopsy NOUN fnp-9165 227 5 are be AUX fnp-9165 227 6 sometimes sometimes ADV fnp-9165 227 7 still still ADV fnp-9165 227 8 performed perform VERB fnp-9165 227 9 in in ADP fnp-9165 227 10 tr tr VERB fnp-9165 227 11 patients patient NOUN fnp-9165 227 12 on on ADP fnp-9165 227 13 statins statin NOUN fnp-9165 227 14 to to PART fnp-9165 227 15 rapidly rapidly ADV fnp-9165 227 16 rule rule VERB fnp-9165 227 17 out out ADP fnp-9165 227 18 imnm imnm PROPN fnp-9165 227 19 , , PUNCT fnp-9165 227 20 particularly particularly ADV fnp-9165 227 21 when when SCONJ fnp-9165 227 22 there there PRON fnp-9165 227 23 is be VERB fnp-9165 227 24 no no DET fnp-9165 227 25 quick quick ADJ fnp-9165 227 26 access access NOUN fnp-9165 227 27 to to ADP fnp-9165 227 28 serology serology NOUN fnp-9165 227 29 results result NOUN fnp-9165 227 30 . . PUNCT fnp-9165 228 1 our our PRON fnp-9165 228 2 objective objective NOUN fnp-9165 228 3 was be AUX fnp-9165 228 4 to to PART fnp-9165 228 5 describe describe VERB fnp-9165 228 6 histopathological histopathological ADJ fnp-9165 228 7 and and CCONJ fnp-9165 228 8 clinical clinical ADJ fnp-9165 228 9 features feature NOUN fnp-9165 228 10 of of ADP fnp-9165 228 11 tr tr NOUN fnp-9165 228 12 patients patient NOUN fnp-9165 228 13 and and CCONJ fnp-9165 228 14 compare compare VERB fnp-9165 228 15 them they PRON fnp-9165 228 16 with with ADP fnp-9165 228 17 a a DET fnp-9165 228 18 group group NOUN fnp-9165 228 19 of of ADP fnp-9165 228 20 imnm imnm PROPN fnp-9165 228 21 controls control NOUN fnp-9165 228 22 . . PUNCT fnp-9165 229 1 out out ADP fnp-9165 229 2 of of ADP fnp-9165 229 3 924 924 NUM fnp-9165 229 4 muscle muscle NOUN fnp-9165 229 5 biopsies biopsy NOUN fnp-9165 229 6 received receive VERB fnp-9165 229 7 between between ADP fnp-9165 229 8 2019 2019 NUM fnp-9165 229 9 and and CCONJ fnp-9165 229 10 2024 2024 NUM fnp-9165 229 11 at at ADP fnp-9165 229 12 our our PRON fnp-9165 229 13 referral referral ADJ fnp-9165 229 14 center center NOUN fnp-9165 229 15 , , PUNCT fnp-9165 229 16 36 36 NUM fnp-9165 229 17 biopsies biopsy NOUN fnp-9165 229 18 from from ADP fnp-9165 229 19 statin statin NOUN fnp-9165 229 20 - - PUNCT fnp-9165 229 21 exposed expose VERB fnp-9165 229 22 tr tr NOUN fnp-9165 229 23 patients patient NOUN fnp-9165 229 24 and and CCONJ fnp-9165 229 25 29 29 NUM fnp-9165 229 26 anti anti ADJ fnp-9165 229 27 - - ADJ fnp-9165 229 28 hmgcr hmgcr ADJ fnp-9165 229 29 imnm imnm PROPN fnp-9165 229 30 controls control NOUN fnp-9165 229 31 were be AUX fnp-9165 229 32 identified identify VERB fnp-9165 229 33 . . PUNCT fnp-9165 230 1 histopathologic histopathologic ADJ fnp-9165 230 2 analysis analysis NOUN fnp-9165 230 3 revealed reveal VERB fnp-9165 230 4 overlapping overlap VERB fnp-9165 230 5 morphology morphology NOUN fnp-9165 230 6 in in ADP fnp-9165 230 7 85 85 NUM fnp-9165 230 8     SPACE fnp-9165 230 9 % % NOUN fnp-9165 230 10 of of ADP fnp-9165 230 11 cases case NOUN fnp-9165 230 12 . . PUNCT fnp-9165 231 1 discriminating discriminate VERB fnp-9165 231 2 features feature NOUN fnp-9165 231 3 highly highly ADV fnp-9165 231 4 suggestive suggestive ADJ fnp-9165 231 5 of of ADP fnp-9165 231 6 tr tr PUNCT fnp-9165 231 7 included include VERB fnp-9165 231 8 predominance predominance NOUN fnp-9165 231 9 of of ADP fnp-9165 231 10 pale pale ADJ fnp-9165 231 11 acute acute ADJ fnp-9165 231 12 necrotic necrotic ADJ fnp-9165 231 13 fibers fiber NOUN fnp-9165 231 14 ( ( PUNCT fnp-9165 231 15 p p X fnp-9165 231 16     SPACE fnp-9165 231 17 < < X fnp-9165 231 18     SPACE fnp-9165 231 19 0.001 0.001 NUM fnp-9165 231 20 ) ) PUNCT fnp-9165 231 21 , , PUNCT fnp-9165 231 22 groups group NOUN fnp-9165 231 23 of of ADP fnp-9165 231 24 4 4 NUM fnp-9165 231 25 + + CCONJ fnp-9165 231 26 adjacent adjacent ADJ fnp-9165 231 27 necrotic necrotic ADJ fnp-9165 231 28 fibers fiber NOUN fnp-9165 231 29 ( ( PUNCT fnp-9165 231 30 p p X fnp-9165 231 31     SPACE fnp-9165 231 32 < < X fnp-9165 231 33     SPACE fnp-9165 231 34 0.01 0.01 NUM fnp-9165 231 35 ) ) PUNCT fnp-9165 231 36 , , PUNCT fnp-9165 231 37 regenerative regenerative ADJ fnp-9165 231 38 basophilic basophilic ADJ fnp-9165 231 39 cuffs cuff NOUN fnp-9165 231 40 ( ( PUNCT fnp-9165 231 41 p p X fnp-9165 231 42     SPACE fnp-9165 231 43 < < X fnp-9165 231 44     SPACE fnp-9165 231 45 0.001 0.001 NUM fnp-9165 231 46 ) ) PUNCT fnp-9165 231 47 , , PUNCT fnp-9165 231 48 and and CCONJ fnp-9165 231 49 lack lack NOUN fnp-9165 231 50 of of ADP fnp-9165 231 51 lc3 lc3 NOUN fnp-9165 231 52 + + X fnp-9165 231 53 granular granular ADJ fnp-9165 231 54 staining staining NOUN fnp-9165 231 55 in in ADP fnp-9165 231 56 non non ADJ fnp-9165 231 57 - - ADJ fnp-9165 231 58 necrotic necrotic ADJ fnp-9165 231 59 fibers fiber NOUN fnp-9165 231 60 ( ( PUNCT fnp-9165 231 61 p p X fnp-9165 231 62     SPACE fnp-9165 231 63 < < X fnp-9165 231 64     SPACE fnp-9165 231 65 0.001 0.001 NUM fnp-9165 231 66 ) ) PUNCT fnp-9165 231 67 . . PUNCT fnp-9165 232 1 review review NOUN fnp-9165 232 2 of of ADP fnp-9165 232 3 clinical clinical ADJ fnp-9165 232 4 data datum NOUN fnp-9165 232 5 revealed reveal VERB fnp-9165 232 6 acute acute ADJ fnp-9165 232 7 creatinine creatinine NOUN fnp-9165 232 8 elevation elevation NOUN fnp-9165 232 9 in in ADP fnp-9165 232 10 94 94 NUM fnp-9165 232 11     SPACE fnp-9165 232 12 % % NOUN fnp-9165 232 13 of of ADP fnp-9165 232 14 tr tr VERB fnp-9165 232 15 patients patient NOUN fnp-9165 232 16 and and CCONJ fnp-9165 232 17 none none NOUN fnp-9165 232 18 of of ADP fnp-9165 232 19 imnm imnm PROPN fnp-9165 232 20 controls control VERB fnp-9165 232 21 ( ( PUNCT fnp-9165 232 22 p p X fnp-9165 232 23     SPACE fnp-9165 232 24 < < X fnp-9165 232 25     SPACE fnp-9165 232 26 0.001 0.001 NUM fnp-9165 232 27 ) ) PUNCT fnp-9165 232 28 . . PUNCT fnp-9165 233 1 peak peak PROPN fnp-9165 233 2 creatine creatine PROPN fnp-9165 233 3 kinase kinase PROPN fnp-9165 233 4 levels level NOUN fnp-9165 233 5 ( ( PUNCT fnp-9165 233 6 cks cks PROPN fnp-9165 233 7 ) ) PUNCT fnp-9165 233 8 > > PUNCT fnp-9165 233 9     SPACE fnp-9165 233 10 25,000 25,000 NUM fnp-9165 233 11     SPACE fnp-9165 233 12 iu iu PROPN fnp-9165 233 13 / / SYM fnp-9165 233 14 l l NOUN fnp-9165 233 15 were be AUX fnp-9165 233 16 seen see VERB fnp-9165 233 17 in in ADP fnp-9165 233 18 44 44 NUM fnp-9165 233 19     SPACE fnp-9165 233 20 % % NOUN fnp-9165 233 21 of of ADP fnp-9165 233 22 tr tr VERB fnp-9165 233 23 and and CCONJ fnp-9165 233 24 none none NOUN fnp-9165 233 25 of of ADP fnp-9165 233 26 imnm imnm PROPN fnp-9165 233 27 ( ( PUNCT fnp-9165 233 28 p p X fnp-9165 233 29     SPACE fnp-9165 233 30 < < X fnp-9165 233 31     SPACE fnp-9165 233 32 0.0001 0.0001 NUM fnp-9165 233 33 ) ) PUNCT fnp-9165 233 34 . . PUNCT fnp-9165 234 1 cks ck NOUN fnp-9165 234 2 normalized normalize VERB fnp-9165 234 3 on on ADP fnp-9165 234 4 average average ADJ fnp-9165 234 5 in in ADP fnp-9165 234 6 12 12 NUM fnp-9165 234 7 days day NOUN fnp-9165 234 8 ( ( PUNCT fnp-9165 234 9 range range NOUN fnp-9165 234 10 8–21 8–21 NOUN fnp-9165 234 11 ) ) PUNCT fnp-9165 234 12 in in ADP fnp-9165 234 13 tr tr NOUN fnp-9165 234 14 and and CCONJ fnp-9165 234 15 in in ADP fnp-9165 234 16 > > NOUN fnp-9165 234 17 30 30 NUM fnp-9165 234 18 days day NOUN fnp-9165 234 19 in in ADP fnp-9165 234 20 all all DET fnp-9165 234 21 imnm imnm PROPN fnp-9165 234 22 cases case NOUN fnp-9165 234 23 . . PUNCT fnp-9165 235 1 although although SCONJ fnp-9165 235 2 pathology pathology NOUN fnp-9165 235 3 can can AUX fnp-9165 235 4 be be AUX fnp-9165 235 5 discriminating discriminate VERB fnp-9165 235 6 , , PUNCT fnp-9165 235 7 tr tr PRON fnp-9165 235 8 should should AUX fnp-9165 235 9 be be AUX fnp-9165 235 10 confirmed confirm VERB fnp-9165 235 11 by by ADP fnp-9165 235 12 following follow VERB fnp-9165 235 13 cks ck NOUN fnp-9165 235 14 closely closely ADV fnp-9165 235 15 over over ADP fnp-9165 235 16 a a DET fnp-9165 235 17 few few ADJ fnp-9165 235 18 days day NOUN fnp-9165 235 19 without without SCONJ fnp-9165 235 20 immunosuppression immunosuppression NOUN fnp-9165 235 21 and and CCONJ fnp-9165 235 22 muscle muscle NOUN fnp-9165 235 23 biopsy biopsy NOUN fnp-9165 235 24 only only ADV fnp-9165 235 25 performed perform VERB fnp-9165 235 26 to to PART fnp-9165 235 27 confirm confirm VERB fnp-9165 235 28 imnm imnm PROPN fnp-9165 235 29 in in ADP fnp-9165 235 30 patients patient NOUN fnp-9165 235 31 with with ADP fnp-9165 235 32 persistently persistently ADV fnp-9165 235 33 elevated elevate VERB fnp-9165 235 34 cks ck NOUN fnp-9165 235 35 . . PUNCT fnp-9165 235 36     SPACE fnp-9165 236 1 abstract abstract ADJ fnp-9165 236 2 23 23 NUM fnp-9165 236 3 free free ADJ fnp-9165 236 4 neuropathol neuropathol NOUN fnp-9165 236 5 6:23:28 6:23:28 NUM fnp-9165 236 6 muscle muscle NOUN fnp-9165 236 7 biopsy biopsy NOUN fnp-9165 236 8 findings finding NOUN fnp-9165 236 9 in in ADP fnp-9165 236 10 an an DET fnp-9165 236 11 infant infant NOUN fnp-9165 236 12 with with ADP fnp-9165 236 13 arthrogryposis arthrogryposis NOUN fnp-9165 236 14 associated associate VERB fnp-9165 236 15 with with ADP fnp-9165 236 16 a a DET fnp-9165 236 17 thoc2 thoc2 NOUN fnp-9165 236 18 variant variant NOUN fnp-9165 236 19 : : PUNCT fnp-9165 236 20 a a DET fnp-9165 236 21 case case NOUN fnp-9165 236 22 report report NOUN fnp-9165 237 1 leslie leslie PROPN fnp-9165 237 2 e. e. PROPN fnp-9165 237 3 hamilton1,2 hamilton1,2 PROPN fnp-9165 237 4 , , PUNCT fnp-9165 237 5 priya priya PROPN fnp-9165 237 6 bhola1,3 bhola1,3 PROPN fnp-9165 237 7 , , PUNCT fnp-9165 237 8 elizabeth elizabeth PROPN fnp-9165 237 9 nizalik1,2 nizalik1,2 PROPN fnp-9165 237 10 , , PUNCT fnp-9165 237 11 brigitte brigitte PROPN fnp-9165 237 12 bonin1,4 bonin1,4 PROPN fnp-9165 237 13 , , PUNCT fnp-9165 237 14 mark mark VERB fnp-9165 237 15 walker1,4 walker1,4 PROPN fnp-9165 237 16 , , PUNCT fnp-9165 237 17 erika erika PROPN fnp-9165 237 18 bariciak1,5 bariciak1,5 PROPN fnp-9165 237 19 , , PUNCT fnp-9165 237 20 julie julie PROPN fnp-9165 237 21 hurteau hurteau PROPN fnp-9165 237 22 - - PUNCT fnp-9165 237 23 miller1,6 miller1,6 PROPN fnp-9165 237 24 faculty faculty NOUN fnp-9165 237 25 of of ADP fnp-9165 237 26 medicine medicine NOUN fnp-9165 237 27 , , PUNCT fnp-9165 237 28 university university PROPN fnp-9165 237 29 of of ADP fnp-9165 237 30 ottawa ottawa PROPN fnp-9165 237 31 , , PUNCT fnp-9165 237 32 ottawa ottawa PROPN fnp-9165 237 33 , , PUNCT fnp-9165 237 34 canada canada PROPN fnp-9165 237 35 department department PROPN fnp-9165 237 36 of of ADP fnp-9165 237 37 pathology pathology PROPN fnp-9165 237 38 and and CCONJ fnp-9165 237 39 laboratory laboratory NOUN fnp-9165 237 40 medicine medicine NOUN fnp-9165 237 41 , , PUNCT fnp-9165 237 42 children child NOUN fnp-9165 237 43 ’s ’s PART fnp-9165 237 44 hospital hospital NOUN fnp-9165 237 45 of of ADP fnp-9165 237 46 eastern eastern PROPN fnp-9165 237 47 ontario ontario PROPN fnp-9165 237 48 ( ( PUNCT fnp-9165 237 49 cheo cheo PROPN fnp-9165 237 50 ) ) PUNCT fnp-9165 237 51 , , PUNCT fnp-9165 237 52 ottawa ottawa PROPN fnp-9165 237 53 , , PUNCT fnp-9165 237 54 canada canada PROPN fnp-9165 237 55 department department PROPN fnp-9165 237 56 of of ADP fnp-9165 237 57 genetics genetics PROPN fnp-9165 237 58 , , PUNCT fnp-9165 237 59 children child NOUN fnp-9165 237 60 ’s ’s PART fnp-9165 237 61 hospital hospital NOUN fnp-9165 237 62 of of ADP fnp-9165 237 63 eastern eastern PROPN fnp-9165 237 64 ontario ontario PROPN fnp-9165 237 65 ( ( PUNCT fnp-9165 237 66 cheo cheo PROPN fnp-9165 237 67 ) ) PUNCT fnp-9165 237 68 , , PUNCT fnp-9165 237 69 ottawa ottawa PROPN fnp-9165 237 70 , , PUNCT fnp-9165 237 71 canada canada PROPN fnp-9165 237 72 division division NOUN fnp-9165 237 73 of of ADP fnp-9165 237 74 maternal maternal ADJ fnp-9165 237 75 fetal fetal ADJ fnp-9165 237 76 medicine medicine NOUN fnp-9165 237 77 , , PUNCT fnp-9165 237 78 department department NOUN fnp-9165 237 79 of of ADP fnp-9165 237 80 obstetrics obstetric NOUN fnp-9165 237 81 , , PUNCT fnp-9165 237 82 gynecology gynecology NOUN fnp-9165 237 83 and and CCONJ fnp-9165 237 84 newborn newborn ADJ fnp-9165 237 85 care care NOUN fnp-9165 237 86 , , PUNCT fnp-9165 237 87 the the DET fnp-9165 237 88 ottawa ottawa PROPN fnp-9165 237 89 hospital hospital PROPN fnp-9165 237 90 , , PUNCT fnp-9165 237 91 ottawa ottawa PROPN fnp-9165 237 92 , , PUNCT fnp-9165 237 93 canada canada PROPN fnp-9165 237 94 division division NOUN fnp-9165 237 95 of of ADP fnp-9165 237 96 neonatology neonatology NOUN fnp-9165 237 97 , , PUNCT fnp-9165 237 98 department department NOUN fnp-9165 237 99 of of ADP fnp-9165 237 100 pediatrics pediatric NOUN fnp-9165 237 101 , , PUNCT fnp-9165 237 102 children child NOUN fnp-9165 237 103 ’s ’s PART fnp-9165 237 104 hospital hospital NOUN fnp-9165 237 105 of of ADP fnp-9165 237 106 eastern eastern PROPN fnp-9165 237 107 ontario ontario PROPN fnp-9165 237 108 ( ( PUNCT fnp-9165 237 109 cheo cheo PROPN fnp-9165 237 110 ) ) PUNCT fnp-9165 237 111 and and CCONJ fnp-9165 237 112 the the DET fnp-9165 237 113 ottawa ottawa PROPN fnp-9165 237 114 hospital hospital PROPN fnp-9165 237 115 , , PUNCT fnp-9165 237 116 ottawa ottawa PROPN fnp-9165 237 117 , , PUNCT fnp-9165 237 118 canada canada PROPN fnp-9165 237 119 department department PROPN fnp-9165 237 120 of of ADP fnp-9165 237 121 medical medical ADJ fnp-9165 237 122 imaging imaging NOUN fnp-9165 237 123 , , PUNCT fnp-9165 237 124 children child NOUN fnp-9165 237 125 ’s ’s PART fnp-9165 237 126 hospital hospital NOUN fnp-9165 237 127 of of ADP fnp-9165 237 128 eastern eastern PROPN fnp-9165 237 129 ontario ontario PROPN fnp-9165 237 130 ( ( PUNCT fnp-9165 237 131 cheo cheo PROPN fnp-9165 237 132 ) ) PUNCT fnp-9165 237 133 , , PUNCT fnp-9165 237 134 ottawa ottawa PROPN fnp-9165 237 135 , , PUNCT fnp-9165 237 136 canada canada PROPN fnp-9165 237 137 this this DET fnp-9165 237 138 case case NOUN fnp-9165 237 139 report report NOUN fnp-9165 237 140 provides provide VERB fnp-9165 237 141 the the DET fnp-9165 237 142 second second ADJ fnp-9165 237 143 reported report VERB fnp-9165 237 144 description description NOUN fnp-9165 237 145 of of ADP fnp-9165 237 146 muscle muscle NOUN fnp-9165 237 147 biopsy biopsy NOUN fnp-9165 237 148 findings finding NOUN fnp-9165 237 149 in in ADP fnp-9165 237 150 an an DET fnp-9165 237 151 infant infant NOUN fnp-9165 237 152 with with ADP fnp-9165 237 153 arthrogryposis arthrogryposis NOUN fnp-9165 237 154 associated associate VERB fnp-9165 237 155 with with ADP fnp-9165 237 156 a a DET fnp-9165 237 157 thoc2 thoc2 NOUN fnp-9165 237 158 variant variant NOUN fnp-9165 237 159 . . PUNCT fnp-9165 238 1 thoc2 thoc2 NOUN fnp-9165 238 2 - - PUNCT fnp-9165 238 3 related relate VERB fnp-9165 238 4 neurodevelopmental neurodevelopmental ADJ fnp-9165 238 5 disorder disorder NOUN fnp-9165 238 6 is be AUX fnp-9165 238 7 caused cause VERB fnp-9165 238 8 by by ADP fnp-9165 238 9 deleterious deleterious ADJ fnp-9165 238 10 variants variant NOUN fnp-9165 238 11 in in ADP fnp-9165 238 12 thoc2 thoc2 NOUN fnp-9165 238 13 ; ; PUNCT fnp-9165 238 14 this this DET fnp-9165 238 15 gene gene NOUN fnp-9165 238 16 encodes encode VERB fnp-9165 238 17 a a DET fnp-9165 238 18 component component NOUN fnp-9165 238 19 of of ADP fnp-9165 238 20 the the DET fnp-9165 238 21 trex trex PROPN fnp-9165 238 22 ( ( PUNCT fnp-9165 238 23 transcription transcription NOUN fnp-9165 238 24 - - PUNCT fnp-9165 238 25 export export NOUN fnp-9165 238 26 ) ) PUNCT fnp-9165 238 27 complex complex NOUN fnp-9165 238 28 , , PUNCT fnp-9165 238 29 which which PRON fnp-9165 238 30 plays play VERB fnp-9165 238 31 a a DET fnp-9165 238 32 critical critical ADJ fnp-9165 238 33 role role NOUN fnp-9165 238 34 in in ADP fnp-9165 238 35 mrna mrna PROPN fnp-9165 238 36 processing processing NOUN fnp-9165 238 37 and and CCONJ fnp-9165 238 38 export export NOUN fnp-9165 238 39 . . PUNCT fnp-9165 239 1 thoc2 thoc2 NOUN fnp-9165 239 2 - - PUNCT fnp-9165 239 3 related relate VERB fnp-9165 239 4 disorder disorder NOUN fnp-9165 239 5 is be AUX fnp-9165 239 6 characterized characterize VERB fnp-9165 239 7 by by ADP fnp-9165 239 8 intellectual intellectual ADJ fnp-9165 239 9 disability disability NOUN fnp-9165 239 10 , , PUNCT fnp-9165 239 11 often often ADV fnp-9165 239 12 associated associate VERB fnp-9165 239 13 with with ADP fnp-9165 239 14 seizure seizure NOUN fnp-9165 239 15 disorders disorder NOUN fnp-9165 239 16 , , PUNCT fnp-9165 239 17 infantile infantile ADJ fnp-9165 239 18 hypotonia hypotonia NOUN fnp-9165 239 19 , , PUNCT fnp-9165 239 20 tremors tremor NOUN fnp-9165 239 21 , , PUNCT fnp-9165 239 22 gait gait VERB fnp-9165 239 23 disturbance disturbance NOUN fnp-9165 239 24 and and CCONJ fnp-9165 239 25 growth growth NOUN fnp-9165 239 26 impairment impairment NOUN fnp-9165 239 27 . . PUNCT fnp-9165 240 1 more more ADV fnp-9165 240 2 recently recently ADV fnp-9165 240 3 , , PUNCT fnp-9165 240 4 thoc2 thoc2 NOUN fnp-9165 240 5 variants variant NOUN fnp-9165 240 6 have have AUX fnp-9165 240 7 been be AUX fnp-9165 240 8 linked link VERB fnp-9165 240 9 to to ADP fnp-9165 240 10 x x ADJ fnp-9165 240 11 - - VERB fnp-9165 240 12 linked link VERB fnp-9165 240 13 recessive recessive ADJ fnp-9165 240 14 fetal fetal ADJ fnp-9165 240 15 arthrogryposis arthrogryposis NOUN fnp-9165 240 16 multiplex multiplex NOUN fnp-9165 240 17 congenita congenita PROPN fnp-9165 240 18 ( ( PUNCT fnp-9165 240 19 cureus cureus NOUN fnp-9165 240 20 2021 2021 NUM fnp-9165 240 21 ; ; PUNCT fnp-9165 240 22 13(11):e19682 13(11):e19682 NUM fnp-9165 240 23 ; ; PUNCT fnp-9165 240 24 nmd nmd PROPN fnp-9165 240 25 2023;33(12):978 2023;33(12):978 PROPN fnp-9165 240 26 - - SYM fnp-9165 240 27 982 982 NUM fnp-9165 240 28 ) ) PUNCT fnp-9165 240 29 . . PUNCT fnp-9165 241 1 we we PRON fnp-9165 241 2 present present VERB fnp-9165 241 3 a a DET fnp-9165 241 4 case case NOUN fnp-9165 241 5 of of ADP fnp-9165 241 6 an an DET fnp-9165 241 7 infant infant NOUN fnp-9165 241 8 who who PRON fnp-9165 241 9 died die VERB fnp-9165 241 10 shortly shortly ADV fnp-9165 241 11 after after ADP fnp-9165 241 12 birth birth NOUN fnp-9165 241 13 at at ADP fnp-9165 241 14 33 33 NUM fnp-9165 241 15 weeks week NOUN fnp-9165 241 16 gestational gestational ADJ fnp-9165 241 17 age age NOUN fnp-9165 241 18 ( ( PUNCT fnp-9165 241 19 ga ga PROPN fnp-9165 241 20 ) ) PUNCT fnp-9165 241 21 . . PUNCT fnp-9165 242 1 a a DET fnp-9165 242 2 fetal fetal ADJ fnp-9165 242 3 ultrasound ultrasound NOUN fnp-9165 242 4 at at ADP fnp-9165 242 5 30 30 NUM fnp-9165 242 6 weeks week NOUN fnp-9165 242 7 ga ga PROPN fnp-9165 242 8 was be AUX fnp-9165 242 9 significant significant ADJ fnp-9165 242 10 for for ADP fnp-9165 242 11 arthrogryposis arthrogryposis NOUN fnp-9165 242 12 , , PUNCT fnp-9165 242 13 hydrops hydrop NOUN fnp-9165 242 14 and and CCONJ fnp-9165 242 15 massive massive ADJ fnp-9165 242 16 polyhydramnios polyhydramnio NOUN fnp-9165 242 17 . . PUNCT fnp-9165 243 1 genetics genetic NOUN fnp-9165 243 2 consultation consultation NOUN fnp-9165 243 3 and and CCONJ fnp-9165 243 4 amniocentesis amniocentesis NOUN fnp-9165 243 5 was be AUX fnp-9165 243 6 pursued pursue VERB fnp-9165 243 7 prior prior ADV fnp-9165 243 8 to to ADP fnp-9165 243 9 delivery delivery NOUN fnp-9165 243 10 , , PUNCT fnp-9165 243 11 and and CCONJ fnp-9165 243 12 initial initial ADJ fnp-9165 243 13 genetic genetic ADJ fnp-9165 243 14 testing testing NOUN fnp-9165 243 15 showed show VERB fnp-9165 243 16 a a DET fnp-9165 243 17 normal normal ADJ fnp-9165 243 18 karyotype karyotype NOUN fnp-9165 243 19 and and CCONJ fnp-9165 243 20 rapid rapid ADJ fnp-9165 243 21 aneuploidy aneuploidy ADJ fnp-9165 243 22 detection detection NOUN fnp-9165 243 23 ( ( PUNCT fnp-9165 243 24 rad rad NOUN fnp-9165 243 25 ) ) PUNCT fnp-9165 243 26 . . PUNCT fnp-9165 244 1 a a DET fnp-9165 244 2 limited limit VERB fnp-9165 244 3 postmortem postmortem NOUN fnp-9165 244 4 examination examination NOUN fnp-9165 244 5 was be AUX fnp-9165 244 6 performed perform VERB fnp-9165 244 7 . . PUNCT fnp-9165 245 1 biopsy biopsy NOUN fnp-9165 245 2 of of ADP fnp-9165 245 3 the the DET fnp-9165 245 4 quadriceps quadricep NOUN fnp-9165 245 5 muscle muscle NOUN fnp-9165 245 6 was be AUX fnp-9165 245 7 significant significant ADJ fnp-9165 245 8 for for ADP fnp-9165 245 9 moderate moderate ADJ fnp-9165 245 10 variation variation NOUN fnp-9165 245 11 in in ADP fnp-9165 245 12 myofiber myofiber ADJ fnp-9165 245 13 size size NOUN fnp-9165 245 14 , , PUNCT fnp-9165 245 15 and and CCONJ fnp-9165 245 16 cytoplasmic cytoplasmic ADJ fnp-9165 245 17 bodies body NOUN fnp-9165 245 18 within within ADP fnp-9165 245 19 several several ADJ fnp-9165 245 20 myofibers myofiber NOUN fnp-9165 245 21 . . PUNCT fnp-9165 246 1 trio trio ADJ fnp-9165 246 2 whole whole ADJ fnp-9165 246 3 exome exome NOUN fnp-9165 246 4 sequencing sequencing NOUN fnp-9165 246 5 detected detect VERB fnp-9165 246 6 a a DET fnp-9165 246 7 hemizygous hemizygous ADJ fnp-9165 246 8 , , PUNCT fnp-9165 246 9 likely likely ADJ fnp-9165 246 10 pathogenic pathogenic ADJ fnp-9165 246 11 variant variant NOUN fnp-9165 246 12 in in ADP fnp-9165 246 13 thoc2,c.2482 thoc2,c.2482 PROPN fnp-9165 246 14 - - PUNCT fnp-9165 246 15 1_2482del 1_2482del NUM fnp-9165 246 16 . . PUNCT fnp-9165 247 1 the the DET fnp-9165 247 2 results result NOUN fnp-9165 247 3 of of ADP fnp-9165 247 4 muscle muscle NOUN fnp-9165 247 5 biopsy biopsy NOUN fnp-9165 247 6 are be AUX fnp-9165 247 7 identical identical ADJ fnp-9165 247 8 to to ADP fnp-9165 247 9 those those PRON fnp-9165 247 10 described describe VERB fnp-9165 247 11 in in ADP fnp-9165 247 12 a a DET fnp-9165 247 13 previously previously ADV fnp-9165 247 14 reported report VERB fnp-9165 247 15 fetus fetus NOUN fnp-9165 247 16 with with ADP fnp-9165 247 17 arthrogryposis arthrogryposis NOUN fnp-9165 247 18 and and CCONJ fnp-9165 247 19 a a DET fnp-9165 247 20 thoc2 thoc2 NOUN fnp-9165 247 21 variant variant NOUN fnp-9165 247 22 ( ( PUNCT fnp-9165 247 23 nmd nmd PROPN fnp-9165 247 24 2023;33(12):978 2023;33(12):978 PROPN fnp-9165 247 25 - - PUNCT fnp-9165 247 26 982 982 NUM fnp-9165 247 27 ) ) PUNCT fnp-9165 247 28 , , PUNCT fnp-9165 247 29 further far ADV fnp-9165 247 30 validating validate VERB fnp-9165 247 31 this this DET fnp-9165 247 32 neuromuscular neuromuscular ADJ fnp-9165 247 33 phenotype phenotype NOUN fnp-9165 247 34 . . PUNCT fnp-9165 248 1 this this DET fnp-9165 248 2 case case NOUN fnp-9165 248 3 report report NOUN fnp-9165 248 4 highlights highlight VERB fnp-9165 248 5 the the DET fnp-9165 248 6 critical critical ADJ fnp-9165 248 7 role role NOUN fnp-9165 248 8 that that PRON fnp-9165 248 9 the the DET fnp-9165 248 10 correlation correlation NOUN fnp-9165 248 11 of of ADP fnp-9165 248 12 whole whole ADJ fnp-9165 248 13 exome exome NOUN fnp-9165 248 14 sequencing sequence VERB fnp-9165 248 15 and and CCONJ fnp-9165 248 16 postmortem postmortem NOUN fnp-9165 248 17 examinations examination NOUN fnp-9165 248 18 play play VERB fnp-9165 248 19 in in ADP fnp-9165 248 20 expanding expand VERB fnp-9165 248 21 our our PRON fnp-9165 248 22 clinical clinical ADJ fnp-9165 248 23 knowledge knowledge NOUN fnp-9165 248 24 of of ADP fnp-9165 248 25 rare rare ADJ fnp-9165 248 26 genetic genetic ADJ fnp-9165 248 27 diseases disease NOUN fnp-9165 248 28 and and CCONJ fnp-9165 248 29 their their PRON fnp-9165 248 30 phenotypes phenotype NOUN fnp-9165 248 31 . . PUNCT fnp-9165 249 1 copyright copyright NOUN fnp-9165 249 2 : : PUNCT fnp-9165 249 3 © © PROPN fnp-9165 249 4 2025 2025 NUM fnp-9165 249 5 the the DET fnp-9165 249 6 author(s author(s NOUN fnp-9165 249 7 ) ) PUNCT fnp-9165 249 8 . . PUNCT fnp-9165 250 1 this this PRON fnp-9165 250 2 is be AUX fnp-9165 250 3 an an DET fnp-9165 250 4 open open ADJ fnp-9165 250 5 access access NOUN fnp-9165 250 6 article article NOUN fnp-9165 250 7 distributed distribute VERB fnp-9165 250 8 under under ADP fnp-9165 250 9 the the DET fnp-9165 250 10 terms term NOUN fnp-9165 250 11 of of ADP fnp-9165 250 12 the the DET fnp-9165 250 13 creative creative ADJ fnp-9165 250 14 commons common NOUN fnp-9165 250 15 attribution attribution NOUN fnp-9165 250 16 4.0 4.0 NUM fnp-9165 250 17 international international ADJ fnp-9165 250 18 license license NOUN fnp-9165 250 19 ( ( PUNCT fnp-9165 250 20 https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/ PROPN fnp-9165 250 21 ) ) PUNCT fnp-9165 250 22 , , PUNCT fnp-9165 250 23 which which PRON fnp-9165 250 24 permits permit VERB fnp-9165 250 25 unrestricted unrestricted ADJ fnp-9165 250 26 use use NOUN fnp-9165 250 27 , , PUNCT fnp-9165 250 28 distribution distribution NOUN fnp-9165 250 29 , , PUNCT fnp-9165 250 30 and and CCONJ fnp-9165 250 31 reproduction reproduction NOUN fnp-9165 250 32 in in ADP fnp-9165 250 33 any any DET fnp-9165 250 34 medium medium NOUN fnp-9165 250 35 , , PUNCT fnp-9165 250 36 provided provide VERB fnp-9165 250 37 the the DET fnp-9165 250 38 original original ADJ fnp-9165 250 39 author author NOUN fnp-9165 250 40 and and CCONJ fnp-9165 250 41 source source NOUN fnp-9165 250 42 are be AUX fnp-9165 250 43 credited credit VERB fnp-9165 250 44 , , PUNCT fnp-9165 250 45 a a DET fnp-9165 250 46 link link NOUN fnp-9165 250 47 to to ADP fnp-9165 250 48 the the DET fnp-9165 250 49 creative creative ADJ fnp-9165 250 50 commons common NOUN fnp-9165 250 51 license license NOUN fnp-9165 250 52 is be AUX fnp-9165 250 53 provided provide VERB fnp-9165 250 54 , , PUNCT fnp-9165 250 55 and and CCONJ fnp-9165 250 56 any any DET fnp-9165 250 57 changes change NOUN fnp-9165 250 58 are be AUX fnp-9165 250 59 indicated indicate VERB fnp-9165 250 60 . . PUNCT fnp-9165 251 1 the the DET fnp-9165 251 2 creative creative ADJ fnp-9165 251 3 commons common NOUN fnp-9165 251 4 public public ADJ fnp-9165 251 5 domain domain NOUN fnp-9165 251 6 dedication dedication NOUN fnp-9165 251 7 waiver waiver NOUN fnp-9165 251 8 ( ( PUNCT fnp-9165 251 9 https://creativecommons.org/publicdomain/zero/1.0/ https://creativecommons.org/publicdomain/zero/1.0/ PROPN fnp-9165 251 10 ) ) PUNCT fnp-9165 251 11 applies apply VERB fnp-9165 251 12 to to ADP fnp-9165 251 13 the the DET fnp-9165 251 14 data datum NOUN fnp-9165 251 15 made make VERB fnp-9165 251 16 available available ADJ fnp-9165 251 17 in in ADP fnp-9165 251 18 this this DET fnp-9165 251 19 article article NOUN fnp-9165 251 20 , , PUNCT fnp-9165 251 21 unless unless SCONJ fnp-9165 251 22 otherwise otherwise ADV fnp-9165 251 23 stated state VERB fnp-9165 251 24 . . PUNCT