        item: #1 of 13
          id: cord-006788-kz8i4a6h
      author: Li, Xiaokun
       title: The FGF metabolic axis
        date: 2019-09-07
       words: 9363
      flesch: 26
     summary: FGF21 metabolic axes play multifaceted roles in controlling the homeostasis of lipid, glucose, and energy metabolism. These findings highlight the role of FGF21 metabolic axis as a defensive barrier for the deleterious stress damage caused by metabolic disorders in the liver
    keywords: acid; adipose; axes; axis; bile; cell; effects; endocrine; factor; fgf19; fgf21; fgfs; growth; growth factor; homeostasis; levels; liver; metabolic; mice; stress; tissue
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        item: #2 of 13
          id: cord-253452-feb75ei4
      author: Yang, Xingyue
       title: Systematic review for geo-authentic Lonicerae Japonicae Flos
        date: 2017-04-19
       words: 4669
      flesch: 37
     summary: The results showed that the method of electron probe was effective in appraising and distinguishing the quality of Lonicerae Japonicae Flos because it could be used to distinguish the content of elements in the cell of different Lonicerae Japonicae Flos, which was controlled by genetic factor. The research about geoauthentic Lonicerae Japonicae Flos is growing in recent years, but no systematic review exists.
    keywords: chinese; fingerprint; flos; geo; japonicae; japonicae flos; lonicerae; lonicerae japonicae; quality; studies
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        item: #3 of 13
          id: cord-274477-jkjyh4cs
      author: Zhang, Zhiruo
       title: Protecting healthcare personnel from 2019-nCoV infection risks: lessons and suggestions
        date: 2020-03-23
       words: 1476
      flesch: 46
     summary: Little knowledge about the novel virus led to a surge of HCP infection in the first month after the outbreak. The grim shortage of protective equipment greatly increased the risk of HCP infections at the onset of the outbreak, exacerbating the spread of diseases among visitors, staff, and patients.
    keywords: hcp; health; healthcare; infection; outbreak
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        item: #4 of 13
          id: cord-287222-wojyisu0
      author: Zhou, Min
       title: Coronavirus disease 2019 (COVID-19): a clinical update
        date: 2020-04-02
       words: 5692
      flesch: 34
     summary: Unlike influenza pneumonia, which usually exhibited unilateral GGO and significant solid nodules, only 6% of COVID-19 patients had solid nodules A majority of COVID-19 patients showed normal leucocyte count, and nearly one third had leucopenia
    keywords: china; clinical; coronavirus; covid-19; disease; infection; novel; patients; plasma; pneumonia; sars; study; syndrome; treatment; ventilation
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        item: #5 of 13
          id: cord-307995-8q7efrqk
      author: Al-Tawfiq, Jaffar A.
       title: Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
        date: 2016-05-04
       words: 4444
      flesch: 51
     summary: Mitigation through Detection, Research, and Response Saudi Arabia and the emergence of a novel coronavirus Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia An update on Middle East respiratory syndrome: 2 years later Health care worker contact with MERS patient, Saudi Arabia Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Middle East respiratory syndrome coronavirus case definition for reporting to WHO: interim case definition 14 Middle East respiratory syndrome coronavirus: epidemiology and disease control measures Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Family cluster of Middle East respiratory syndrome coronavirus infections A family cluster of Middle East Respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study KSA MERS-CoV Investigation Team. Estimating Potential Incidence of MERS-CoV Associated with Hajj Pilgrims to Saudi Arabia Imported cases of Middle East respiratory syndrome: an update The Hajj pilgrimage and surveillance for Middle East Respiratory syndrome coronavirus in pilgrims from African countries High prevalence of common respiratory viruses and no evidence of Middle East respiratory syndrome coronavirus in Hajj pilgrims returning to Ghana Lack of MERS coronavirus but prevalence of influenza virus in French pilgrims after Prevalence of MERS-CoV nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj Lack of MERS coronavirus neutralizing antibodies in humans, eastern province, Saudi Arabia Transmission of MERS-coronavirus in household contacts Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Heat inactivation of the Middle East respiratory syndrome coronavirus Infection prevention and control of epidemic-and pandemic prone acute respiratory infections in health care Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus Treating MERS-CoV during an outbreak Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Ribavirin and interferon α-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Inhibition of novel coronavirus replication by a combination of interferon-α2b and ribavirin Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Combination therapy with lopinavir/ritonavir, ribavirin and interferon-α for Middle East respiratory syndrome: a case report
    keywords: cases; coronavirus; cov; east; infection; mers; middle; patients; syndrome; transmission
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        item: #6 of 13
          id: cord-308673-dkmpayk4
      author: Ni, Li
       title: Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19 in Wuhan
        date: 2020-03-13
       words: 1717
      flesch: 57
     summary: By February 14, the number of confirmed patients and deaths were 37 914 and 1123, respectively, and the mortality of COVID-19 was 2.96% in Wuhan City, Hubei Province, which is considered as the origin of first cluster of patients [3] . This report suggests that SHL treatment might be effective for COVID-19 and warrants subsequent clinical trials to obtain sufficient evidence for clinical recommendation.
    keywords: case; covid-19; january; shl
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        item: #7 of 13
          id: cord-310331-29srzbuk
      author: Xu, Jiuyang
       title: 2019 novel Coronavirus outbreak: a quiz or final exam?
        date: 2020-03-20
       words: 2030
      flesch: 48
     summary: Front Med DOI: 10.1007/s11684-020-0753-1 sha: doc_id: 310331 cord_uid: 29srzbuk The 2019 novel Coronavirus (2019-nCoV) is an emerging pathogen and is threatening the global health. 2019-nCoV is the third highly pathogenic coronavirus emerging in the 21st century, also one of the epidemics or pandemics since the millennium (Fig. 1) .
    keywords: china; coronavirus; health; ncov; novel; outbreak
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        item: #8 of 13
          id: cord-312361-ermbijfq
      author: Gong, Fanghua
       title: China’s local governments are combating COVID-19 with unprecedented responses — from a Wenzhou governance perspective
        date: 2020-03-12
       words: 1894
      flesch: 40
     summary: Wenzhou sounds the bugle call to beat epidemic spread Commanding China's fight against novel coronavirus outbreak Number of confirmed COVID-19 cases in Wenzhou from Wenzhou people are known far and wide as people with entrepreneurship, determination, and collective spirits.
    keywords: china; control; epidemic; measures; prevention; wenzhou
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        item: #9 of 13
          id: cord-330198-pwkxgbxk
      author: Cai, Xiaofang
       title: Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19
        date: 2020-10-27
       words: 4293
      flesch: 45
     summary: Although we strictly adhered to two pre-examinations and triage for all outpatients, most of the probable and confirmed COVID-19 cases were admitted from the fever clinic, and 12.5% (97/773) of the probable COVID-19 cases (including 5.3% (13/245) of confirmed COVID-19 cases) with atypical symptoms or critical illness were admitted from the emergency department. The incidence of fever was higher in non-COVID-19 cases (31, 75.6%) than that in confirmed COVID-19 cases (7, 53.8%) and suspected COVID-19 cases (19, 44.2%) (P = 0.013).
    keywords: cases; cells; children; cov-2; covid-19; non; patients; sars
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        item: #10 of 13
          id: cord-331228-wbd0s4fo
      author: Shehata, Mahmoud M.
       title: Middle East respiratory syndrome coronavirus: a comprehensive review
        date: 2016-01-20
       words: 7527
      flesch: 43
     summary: respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies Protective efficacy of recombinant Modified Vaccinia virus Ankara (MVA) delivering Middle East Respiratory Syndrome coronavirus spike glycoprotein Evaluation of candidate vaccine approaches for MERS-CoV Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Cyclophilins as modulators of viral replication Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Ribavirin and interferon α-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis Testing of Middle East respiratory syndrome coronavirus replication inhibitors for the ability to block viral entry Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus The newly emerged SARS-like coronavirus HCoV-EMC also has an Achilles' heel: current effective inhibitor targeting a 3C-like protease Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Mahmoud M. Shehata, Mokhtar R. Gomaa, Mohamed A. Ali, and Ghazi Kayali declare that they have no conflict of interest. respiratory syndrome coronavirus The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies Inhibition of proprotein convertases abrogates processing of the middle eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein Furin at the cutting edge: from protein traffic to embryogenesis and disease MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features Characterization of the coronavirus M protein and nucleocapsid interaction in infected cells SARS-beginning to understand a new virus Wildtype and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Pneumonia from human coronavirus in a macaque model Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Infection with MERS-CoV causes lethal pneumonia in the common marmoset The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Novel coronavirus-Saudi Arabia: human isolate.
    keywords: antibodies; arabia; camels; cases; cell; coronavirus; cov; east; human; infection; mers; middle; middle east; protein; saudi; syndrome; syndrome coronavirus
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        item: #11 of 13
          id: cord-338258-bdyalfcd
      author: Chen, Enfu
       title: The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report
        date: 2013-06-10
       words: 3403
      flesch: 48
     summary: The HA gene sequence from the patient indicated that the virus may be better adapted to infecting mammals than other avian influenza viruses because of the presence of Q226I in the Zhejiang strain and Q226L in the Shanghai 01 strain; the HA protein potentially enhanced the ability to bind to mammalian-like receptors with sialic acid moieties linked to galactose via α-2,6 linkages [21, 22] . Enhanced and expanded surveillance to ensure immediate discovery, diagnosis, and treatment of suspected cases will reduce the number of severe H7N9 cases and deaths.
    keywords: avian; cases; china; h7n9; human; influenza; patient; virus; zhejiang
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        item: #12 of 13
          id: cord-344480-6tcush4w
      author: Zhou, Guangbiao
       title: Back to the spring of Wuhan: facts and hope of COVID-19 outbreak
        date: 2020-03-14
       words: 1568
      flesch: 45
     summary: [14, 15] , and a virus with 99% sequence homology to the receptor-binding domain (RBD) and 90% to the SARS-CoV-2 genome was also found in Malayan pangolins in southern China China Novel Coronavirus Investigating and Research Team.
    keywords: china; coronavirus; covid-19; novel; wuhan
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        item: #13 of 13
          id: cord-347414-t88654wo
      author: Peng, Mian
       title: Successful management of seven cases of critical COVID-19 with early noninvasive-invasive sequential ventilation algorithm and bundle pharmacotherapy
        date: 2020-08-06
       words: 2754
      flesch: 43
     summary: Thus, we concluded that good outcomes for patients with critical COVID-19 can be achieved with early noninvasive–invasive sequential ventilation and bundle pharmacotherapy. In December of 2019, a cluster of patients with pneumonia of unknown cause was linked to transmission at a seafood wholesale market in Wuhan, China.
    keywords: coronavirus; covid-19; days; patients; pneumonia; sars
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