id	sid	tid	token	lemma	pos
fcis-1883	1	1	frontiers	frontier	NOUN
fcis-1883	1	2	in	in	ADP
fcis-1883	1	3	computing	computing	NOUN
fcis-1883	1	4	and	and	CCONJ
fcis-1883	1	5	intelligent	intelligent	ADJ
fcis-1883	1	6	systems	system	NOUN
fcis-1883	1	7	issn	issn	VERB
fcis-1883	1	8	:	:	PUNCT
fcis-1883	1	9	2832	2832	NUM
fcis-1883	1	10	-	-	SYM
fcis-1883	1	11	6024	6024	NUM
fcis-1883	1	12	|	|	NOUN
fcis-1883	1	13	vol	vol	NOUN
fcis-1883	1	14	.	.	PROPN
fcis-1883	2	1	1	1	NUM
fcis-1883	2	2	,	,	PUNCT
fcis-1883	2	3	no	no	INTJ
fcis-1883	2	4	.	.	NOUN
fcis-1883	2	5	2	2	NUM
fcis-1883	2	6	,	,	PUNCT
fcis-1883	2	7	2022	2022	NUM
fcis-1883	2	8	74	74	NUM
fcis-1883	2	9	research	research	NOUN
fcis-1883	2	10	progress	progress	NOUN
fcis-1883	2	11	on	on	ADP
fcis-1883	2	12	the	the	DET
fcis-1883	2	13	effect	effect	NOUN
fcis-1883	2	14	of	of	ADP
fcis-1883	2	15	calcium	calcium	NOUN
fcis-1883	2	16	overload	overload	NOUN
fcis-1883	2	17	on	on	ADP
fcis-1883	2	18	myocardial	myocardial	ADJ
fcis-1883	2	19	ischemia	ischemia	NOUN
fcis-1883	2	20	-	-	PUNCT
fcis-1883	2	21	reperfusion	reperfusion	NOUN
fcis-1883	2	22	injury	injury	NOUN
fcis-1883	2	23	zhenrun	zhenrun	VERB
fcis-1883	2	24	zhan1,2	zhan1,2	PROPN
fcis-1883	2	25	,	,	PUNCT
fcis-1883	2	26	xiaodan	xiaodan	PROPN
fcis-1883	2	27	bi1,2	bi1,2	PROPN
fcis-1883	2	28	,	,	PUNCT
fcis-1883	2	29	jinpeng	jinpeng	PROPN
fcis-1883	2	30	yang1,2	yang1,2	PROPN
fcis-1883	2	31	,	,	PUNCT
fcis-1883	2	32	tingting	tingte	VERB
fcis-1883	2	33	zhao1,2	zhao1,2	PROPN
fcis-1883	2	34	,	,	PUNCT
fcis-1883	2	35	*	*	SYM
fcis-1883	2	36	1	1	NUM
fcis-1883	2	37	changzhi	changzhi	PROPN
fcis-1883	2	38	medical	medical	PROPN
fcis-1883	2	39	college	college	PROPN
fcis-1883	2	40	,	,	PUNCT
fcis-1883	2	41	changzhi	changzhi	PROPN
fcis-1883	2	42	,	,	PUNCT
fcis-1883	2	43	shanxi	shanxi	PROPN
fcis-1883	2	44	,	,	PUNCT
fcis-1883	2	45	046000	046000	NUM
fcis-1883	2	46	,	,	PUNCT
fcis-1883	2	47	china	china	PROPN
fcis-1883	2	48	2	2	NUM
fcis-1883	2	49	heping	heping	PROPN
fcis-1883	2	50	hospital	hospital	NOUN
fcis-1883	2	51	affiliated	affiliate	VERB
fcis-1883	2	52	to	to	ADP
fcis-1883	2	53	changzhi	changzhi	PROPN
fcis-1883	2	54	medical	medical	PROPN
fcis-1883	2	55	college	college	PROPN
fcis-1883	2	56	,	,	PUNCT
fcis-1883	2	57	changzhi	changzhi	PROPN
fcis-1883	2	58	,	,	PUNCT
fcis-1883	2	59	shanxi	shanxi	PROPN
fcis-1883	2	60	,	,	PUNCT
fcis-1883	2	61	046000	046000	NUM
fcis-1883	2	62	,	,	PUNCT
fcis-1883	2	63	china	china	PROPN
fcis-1883	2	64	*	*	PUNCT
fcis-1883	2	65	corresponding	correspond	VERB
fcis-1883	2	66	author	author	NOUN
fcis-1883	2	67	:	:	PUNCT
fcis-1883	2	68	tingting	tingte	VERB
fcis-1883	2	69	zhao	zhao	X
fcis-1883	2	70	(	(	PUNCT
fcis-1883	2	71	email	email	NOUN
fcis-1883	2	72	:	:	PUNCT
fcis-1883	2	73	649823325@qq.com	649823325@qq.com	NUM
fcis-1883	2	74	)	)	PUNCT
fcis-1883	2	75	abstract	abstract	NOUN
fcis-1883	2	76	:	:	PUNCT
fcis-1883	2	77	in	in	ADP
fcis-1883	2	78	the	the	DET
fcis-1883	2	79	case	case	NOUN
fcis-1883	2	80	of	of	ADP
fcis-1883	2	81	acute	acute	ADJ
fcis-1883	2	82	myocardial	myocardial	ADJ
fcis-1883	2	83	infarction	infarction	NOUN
fcis-1883	2	84	,	,	PUNCT
fcis-1883	2	85	after	after	ADP
fcis-1883	2	86	coronary	coronary	ADJ
fcis-1883	2	87	angioplasty	angioplasty	NOUN
fcis-1883	2	88	,	,	PUNCT
fcis-1883	2	89	thrombolytic	thrombolytic	ADJ
fcis-1883	2	90	therapy	therapy	NOUN
fcis-1883	2	91	and	and	CCONJ
fcis-1883	2	92	cardiac	cardiac	ADJ
fcis-1883	2	93	arrest	arrest	NOUN
fcis-1883	2	94	and	and	CCONJ
fcis-1883	2	95	rebound	rebound	VERB
fcis-1883	2	96	surgery	surgery	NOUN
fcis-1883	2	97	,	,	PUNCT
fcis-1883	2	98	the	the	DET
fcis-1883	2	99	ischemic	ischemic	ADJ
fcis-1883	2	100	myocardium	myocardium	NOUN
fcis-1883	2	101	of	of	ADP
fcis-1883	2	102	patients	patient	NOUN
fcis-1883	2	103	may	may	AUX
fcis-1883	2	104	suffer	suffer	VERB
fcis-1883	2	105	from	from	ADP
fcis-1883	2	106	blood	blood	NOUN
fcis-1883	2	107	reperfusion	reperfusion	NOUN
fcis-1883	2	108	injury	injury	NOUN
fcis-1883	2	109	.	.	PUNCT
fcis-1883	3	1	however	however	ADV
fcis-1883	3	2	,	,	PUNCT
fcis-1883	3	3	this	this	PRON
fcis-1883	3	4	is	be	AUX
fcis-1883	3	5	an	an	DET
fcis-1883	3	6	inevitable	inevitable	ADJ
fcis-1883	3	7	complication	complication	NOUN
fcis-1883	3	8	of	of	ADP
fcis-1883	3	9	treatment	treatment	NOUN
fcis-1883	3	10	,	,	PUNCT
fcis-1883	3	11	mainly	mainly	ADV
fcis-1883	3	12	manifested	manifest	VERB
fcis-1883	3	13	in	in	ADP
fcis-1883	3	14	arrhythmia	arrhythmia	NOUN
fcis-1883	3	15	,	,	PUNCT
fcis-1883	3	16	myocardial	myocardial	ADJ
fcis-1883	3	17	stunning	stunning	ADJ
fcis-1883	3	18	,	,	PUNCT
fcis-1883	3	19	heart	heart	NOUN
fcis-1883	3	20	failure	failure	NOUN
fcis-1883	3	21	and	and	CCONJ
fcis-1883	3	22	so	so	ADV
fcis-1883	3	23	on	on	ADV
fcis-1883	3	24	,	,	PUNCT
fcis-1883	3	25	and	and	CCONJ
fcis-1883	3	26	even	even	ADV
fcis-1883	3	27	death	death	NOUN
fcis-1883	3	28	in	in	ADP
fcis-1883	3	29	severe	severe	ADJ
fcis-1883	3	30	cases	case	NOUN
fcis-1883	3	31	.	.	PUNCT
fcis-1883	4	1	the	the	DET
fcis-1883	4	2	main	main	ADJ
fcis-1883	4	3	mechanisms	mechanism	NOUN
fcis-1883	4	4	of	of	ADP
fcis-1883	4	5	myocardial	myocardial	ADJ
fcis-1883	4	6	ischemia	ischemia	NOUN
fcis-1883	4	7	-	-	PUNCT
fcis-1883	4	8	reperfusion	reperfusion	NOUN
fcis-1883	4	9	injury	injury	NOUN
fcis-1883	4	10	include	include	VERB
fcis-1883	4	11	inflammatory	inflammatory	ADJ
fcis-1883	4	12	response	response	NOUN
fcis-1883	4	13	,	,	PUNCT
fcis-1883	4	14	autophagy	autophagy	NOUN
fcis-1883	4	15	,	,	PUNCT
fcis-1883	4	16	apoptosis	apoptosis	NOUN
fcis-1883	4	17	,	,	PUNCT
fcis-1883	4	18	oxidative	oxidative	ADJ
fcis-1883	4	19	stress	stress	NOUN
fcis-1883	4	20	response	response	NOUN
fcis-1883	4	21	,	,	PUNCT
fcis-1883	4	22	calcium	calcium	NOUN
fcis-1883	4	23	overload	overload	NOUN
fcis-1883	4	24	,	,	PUNCT
fcis-1883	4	25	mitochondrial	mitochondrial	ADJ
fcis-1883	4	26	dysfunction	dysfunction	NOUN
fcis-1883	4	27	and	and	CCONJ
fcis-1883	4	28	so	so	ADV
fcis-1883	4	29	on	on	ADV
fcis-1883	4	30	.	.	PUNCT
fcis-1883	5	1	what	what	PRON
fcis-1883	5	2	makes	make	VERB
fcis-1883	5	3	me	i	PRON
fcis-1883	5	4	curious	curious	ADJ
fcis-1883	5	5	is	be	AUX
fcis-1883	5	6	the	the	DET
fcis-1883	5	7	calcium	calcium	NOUN
fcis-1883	5	8	overload	overload	NOUN
fcis-1883	5	9	mechanism	mechanism	NOUN
fcis-1883	5	10	,	,	PUNCT
fcis-1883	5	11	which	which	PRON
fcis-1883	5	12	is	be	AUX
fcis-1883	5	13	the	the	DET
fcis-1883	5	14	main	main	ADJ
fcis-1883	5	15	inducement	inducement	NOUN
fcis-1883	5	16	of	of	ADP
fcis-1883	5	17	reperfusion	reperfusion	NOUN
fcis-1883	5	18	injury	injury	NOUN
fcis-1883	5	19	,	,	PUNCT
fcis-1883	5	20	and	and	CCONJ
fcis-1883	5	21	can	can	AUX
fcis-1883	5	22	act	act	VERB
fcis-1883	5	23	with	with	ADP
fcis-1883	5	24	other	other	ADJ
fcis-1883	5	25	inducing	induce	VERB
fcis-1883	5	26	mechanisms	mechanism	NOUN
fcis-1883	5	27	to	to	PART
fcis-1883	5	28	further	far	ADV
fcis-1883	5	29	aggravate	aggravate	VERB
fcis-1883	5	30	reperfusion	reperfusion	NOUN
fcis-1883	5	31	injury	injury	NOUN
fcis-1883	5	32	.	.	PUNCT
fcis-1883	6	1	it	it	PRON
fcis-1883	6	2	is	be	AUX
fcis-1883	6	3	an	an	DET
fcis-1883	6	4	important	important	ADJ
fcis-1883	6	5	cause	cause	NOUN
fcis-1883	6	6	of	of	ADP
fcis-1883	6	7	myocardial	myocardial	ADJ
fcis-1883	6	8	injury	injury	NOUN
fcis-1883	6	9	and	and	CCONJ
fcis-1883	6	10	provides	provide	VERB
fcis-1883	6	11	a	a	DET
fcis-1883	6	12	new	new	ADJ
fcis-1883	6	13	idea	idea	NOUN
fcis-1883	6	14	for	for	ADP
fcis-1883	6	15	myocardial	myocardial	ADJ
fcis-1883	6	16	protection	protection	NOUN
fcis-1883	6	17	.	.	PUNCT
fcis-1883	7	1	this	this	DET
fcis-1883	7	2	paper	paper	NOUN
fcis-1883	7	3	comprehensively	comprehensively	ADV
fcis-1883	7	4	discusses	discuss	VERB
fcis-1883	7	5	calcium	calcium	NOUN
fcis-1883	7	6	overload	overload	NOUN
fcis-1883	7	7	from	from	ADP
fcis-1883	7	8	the	the	DET
fcis-1883	7	9	perspective	perspective	NOUN
fcis-1883	7	10	of	of	ADP
fcis-1883	7	11	the	the	DET
fcis-1883	7	12	mechanism	mechanism	NOUN
fcis-1883	7	13	of	of	ADP
fcis-1883	7	14	ischemiareperfusion	ischemiareperfusion	NOUN
fcis-1883	7	15	injury	injury	NOUN
fcis-1883	7	16	.	.	PUNCT
fcis-1883	8	1	keywords	keyword	NOUN
fcis-1883	8	2	:	:	PUNCT
fcis-1883	8	3	calcium	calcium	NOUN
fcis-1883	8	4	overload	overload	NOUN
fcis-1883	8	5	;	;	PUNCT
fcis-1883	8	6	myocardium	myocardium	ADJ
fcis-1883	8	7	;	;	PUNCT
fcis-1883	8	8	ischemia	ischemia	NOUN
fcis-1883	8	9	-	-	PUNCT
fcis-1883	8	10	reperfusion	reperfusion	NOUN
fcis-1883	8	11	injury	injury	NOUN
fcis-1883	8	12	.	.	PUNCT
fcis-1883	9	1	1	1	X
fcis-1883	9	2	.	.	X
fcis-1883	9	3	introduction	introduction	NOUN
fcis-1883	9	4	in	in	ADP
fcis-1883	9	5	clinical	clinical	ADJ
fcis-1883	9	6	work	work	NOUN
fcis-1883	9	7	,	,	PUNCT
fcis-1883	9	8	myocardial	myocardial	ADJ
fcis-1883	9	9	infarction	infarction	NOUN
fcis-1883	9	10	and	and	CCONJ
fcis-1883	9	11	other	other	ADJ
fcis-1883	9	12	diseases	disease	NOUN
fcis-1883	9	13	with	with	ADP
fcis-1883	9	14	insufficient	insufficient	ADJ
fcis-1883	9	15	myocardial	myocardial	ADJ
fcis-1883	9	16	perfusion	perfusion	NOUN
fcis-1883	9	17	seriously	seriously	ADV
fcis-1883	9	18	affect	affect	VERB
fcis-1883	9	19	the	the	DET
fcis-1883	9	20	life	life	NOUN
fcis-1883	9	21	and	and	CCONJ
fcis-1883	9	22	health	health	NOUN
fcis-1883	9	23	of	of	ADP
fcis-1883	9	24	the	the	DET
fcis-1883	9	25	people	people	NOUN
fcis-1883	9	26	,	,	PUNCT
fcis-1883	9	27	but	but	CCONJ
fcis-1883	9	28	with	with	ADP
fcis-1883	9	29	the	the	DET
fcis-1883	9	30	development	development	NOUN
fcis-1883	9	31	of	of	ADP
fcis-1883	9	32	medical	medical	ADJ
fcis-1883	9	33	technology	technology	NOUN
fcis-1883	9	34	,	,	PUNCT
fcis-1883	9	35	the	the	DET
fcis-1883	9	36	development	development	NOUN
fcis-1883	9	37	and	and	CCONJ
fcis-1883	9	38	improvement	improvement	NOUN
fcis-1883	9	39	of	of	ADP
fcis-1883	9	40	coronary	coronary	ADJ
fcis-1883	9	41	intervention	intervention	NOUN
fcis-1883	9	42	and	and	CCONJ
fcis-1883	9	43	heart	heart	NOUN
fcis-1883	9	44	bypass	bypass	NOUN
fcis-1883	9	45	,	,	PUNCT
fcis-1883	9	46	the	the	DET
fcis-1883	9	47	lives	life	NOUN
fcis-1883	9	48	of	of	ADP
fcis-1883	9	49	patients	patient	NOUN
fcis-1883	9	50	with	with	ADP
fcis-1883	9	51	myocardial	myocardial	ADJ
fcis-1883	9	52	infarction	infarction	NOUN
fcis-1883	9	53	are	be	AUX
fcis-1883	9	54	increasingly	increasingly	ADV
fcis-1883	9	55	better	well	ADV
fcis-1883	9	56	protected	protect	VERB
fcis-1883	9	57	.	.	PUNCT
fcis-1883	10	1	some	some	DET
fcis-1883	10	2	studies	study	NOUN
fcis-1883	10	3	have	have	AUX
fcis-1883	10	4	shown	show	VERB
fcis-1883	10	5	that	that	SCONJ
fcis-1883	10	6	after	after	ADP
fcis-1883	10	7	myocardial	myocardial	ADJ
fcis-1883	10	8	ischemia	ischemia	NOUN
fcis-1883	10	9	for	for	ADP
fcis-1883	10	10	more	more	ADJ
fcis-1883	10	11	than	than	ADP
fcis-1883	10	12	a	a	DET
fcis-1883	10	13	certain	certain	ADJ
fcis-1883	10	14	period	period	NOUN
fcis-1883	10	15	of	of	ADP
fcis-1883	10	16	time	time	NOUN
fcis-1883	10	17	,	,	PUNCT
fcis-1883	10	18	myocardial	myocardial	ADJ
fcis-1883	10	19	cells	cell	NOUN
fcis-1883	10	20	will	will	AUX
fcis-1883	10	21	begin	begin	VERB
fcis-1883	10	22	to	to	PART
fcis-1883	10	23	die	die	VERB
fcis-1883	10	24	from	from	ADP
fcis-1883	10	25	damage	damage	NOUN
fcis-1883	10	26	,	,	PUNCT
fcis-1883	10	27	so	so	CCONJ
fcis-1883	10	28	in	in	ADP
fcis-1883	10	29	clinical	clinical	ADJ
fcis-1883	10	30	practice	practice	NOUN
fcis-1883	10	31	,	,	PUNCT
fcis-1883	10	32	we	we	PRON
fcis-1883	10	33	are	be	AUX
fcis-1883	10	34	often	often	ADV
fcis-1883	10	35	asked	ask	VERB
fcis-1883	10	36	to	to	PART
fcis-1883	10	37	give	give	VERB
fcis-1883	10	38	reperfusion	reperfusion	NOUN
fcis-1883	10	39	to	to	ADP
fcis-1883	10	40	ischemic	ischemic	ADJ
fcis-1883	10	41	myocardium	myocardium	NOUN
fcis-1883	10	42	as	as	ADV
fcis-1883	10	43	soon	soon	ADV
fcis-1883	10	44	as	as	ADP
fcis-1883	10	45	possible	possible	ADJ
fcis-1883	10	46	to	to	PART
fcis-1883	10	47	reduce	reduce	VERB
fcis-1883	10	48	the	the	DET
fcis-1883	10	49	damage	damage	NOUN
fcis-1883	10	50	caused	cause	VERB
fcis-1883	10	51	by	by	ADP
fcis-1883	10	52	ischemia	ischemia	NOUN
fcis-1883	10	53	.	.	PUNCT
fcis-1883	11	1	surprisingly	surprisingly	ADV
fcis-1883	11	2	,	,	PUNCT
fcis-1883	11	3	after	after	ADP
fcis-1883	11	4	extensive	extensive	ADJ
fcis-1883	11	5	clinical	clinical	ADJ
fcis-1883	11	6	studies	study	NOUN
fcis-1883	11	7	and	and	CCONJ
fcis-1883	11	8	basic	basic	ADJ
fcis-1883	11	9	research	research	NOUN
fcis-1883	11	10	,	,	PUNCT
fcis-1883	11	11	a	a	DET
fcis-1883	11	12	related	related	ADJ
fcis-1883	11	13	article	article	NOUN
fcis-1883	11	14	[	[	X
fcis-1883	11	15	1	1	X
fcis-1883	11	16	]	]	PUNCT
fcis-1883	11	17	pointed	point	VERB
fcis-1883	11	18	out	out	ADP
fcis-1883	11	19	that	that	SCONJ
fcis-1883	11	20	myocardial	myocardial	ADJ
fcis-1883	11	21	ischemia	ischemia	NOUN
fcis-1883	11	22	-	-	PUNCT
fcis-1883	11	23	reperfusion	reperfusion	NOUN
fcis-1883	11	24	is	be	AUX
fcis-1883	11	25	not	not	PART
fcis-1883	11	26	always	always	ADV
fcis-1883	11	27	beneficial	beneficial	ADJ
fcis-1883	11	28	to	to	PART
fcis-1883	11	29	protect	protect	VERB
fcis-1883	11	30	cardiomyocytes	cardiomyocyte	NOUN
fcis-1883	11	31	,	,	PUNCT
fcis-1883	11	32	but	but	CCONJ
fcis-1883	11	33	instead	instead	ADV
fcis-1883	11	34	can	can	AUX
fcis-1883	11	35	cause	cause	VERB
fcis-1883	11	36	further	further	ADJ
fcis-1883	11	37	damage	damage	NOUN
fcis-1883	11	38	to	to	ADP
fcis-1883	11	39	ischemic	ischemic	ADJ
fcis-1883	11	40	tissue	tissue	NOUN
fcis-1883	11	41	cells	cell	NOUN
fcis-1883	11	42	in	in	ADP
fcis-1883	11	43	some	some	DET
fcis-1883	11	44	cases	case	NOUN
fcis-1883	11	45	,	,	PUNCT
fcis-1883	11	46	namely	namely	ADV
fcis-1883	11	47	myocardial	myocardial	ADJ
fcis-1883	11	48	ischemia	ischemia	NOUN
fcis-1883	11	49	-	-	PUNCT
fcis-1883	11	50	reperfusion	reperfusion	NOUN
fcis-1883	11	51	injury	injury	NOUN
fcis-1883	11	52	(	(	PUNCT
fcis-1883	11	53	mi	mi	NOUN
fcis-1883	11	54	-	-	PROPN
fcis-1883	11	55	ri	ri	NOUN
fcis-1883	11	56	)	)	PUNCT
fcis-1883	11	57	,	,	PUNCT
fcis-1883	11	58	whose	whose	DET
fcis-1883	11	59	main	main	ADJ
fcis-1883	11	60	mechanisms	mechanism	NOUN
fcis-1883	11	61	of	of	ADP
fcis-1883	11	62	occurrence	occurrence	NOUN
fcis-1883	11	63	are	be	AUX
fcis-1883	11	64	inflammatory	inflammatory	ADJ
fcis-1883	11	65	response	response	NOUN
fcis-1883	11	66	,	,	PUNCT
fcis-1883	11	67	autophagy	autophagy	NOUN
fcis-1883	11	68	,	,	PUNCT
fcis-1883	11	69	apoptosis	apoptosis	NOUN
fcis-1883	11	70	,	,	PUNCT
fcis-1883	11	71	oxidative	oxidative	ADJ
fcis-1883	11	72	stress	stress	NOUN
fcis-1883	11	73	response	response	NOUN
fcis-1883	11	74	,	,	PUNCT
fcis-1883	11	75	calcium	calcium	NOUN
fcis-1883	11	76	overload	overload	NOUN
fcis-1883	11	77	,	,	PUNCT
fcis-1883	11	78	and	and	CCONJ
fcis-1883	11	79	mitochondrial	mitochondrial	ADJ
fcis-1883	11	80	dysfunction	dysfunction	NOUN
fcis-1883	12	1	[	[	X
fcis-1883	12	2	2	2	NUM
fcis-1883	12	3	]	]	PUNCT
fcis-1883	12	4	.	.	PUNCT
fcis-1883	13	1	therefore	therefore	ADV
fcis-1883	13	2	,	,	PUNCT
fcis-1883	13	3	the	the	DET
fcis-1883	13	4	prevention	prevention	NOUN
fcis-1883	13	5	and	and	CCONJ
fcis-1883	13	6	treatment	treatment	NOUN
fcis-1883	13	7	of	of	ADP
fcis-1883	13	8	ischemiareperfusion	ischemiareperfusion	NOUN
fcis-1883	13	9	injury	injury	NOUN
fcis-1883	13	10	has	have	AUX
fcis-1883	13	11	become	become	VERB
fcis-1883	13	12	a	a	DET
fcis-1883	13	13	research	research	NOUN
fcis-1883	13	14	hotspot	hotspot	NOUN
fcis-1883	13	15	in	in	ADP
fcis-1883	13	16	many	many	ADJ
fcis-1883	13	17	fields	field	NOUN
fcis-1883	13	18	,	,	PUNCT
fcis-1883	13	19	including	include	VERB
fcis-1883	13	20	heart	heart	NOUN
fcis-1883	13	21	and	and	CCONJ
fcis-1883	13	22	cerebrovascular	cerebrovascular	ADJ
fcis-1883	13	23	.	.	PUNCT
fcis-1883	14	1	in	in	ADP
fcis-1883	14	2	recent	recent	ADJ
fcis-1883	14	3	years	year	NOUN
fcis-1883	14	4	,	,	PUNCT
fcis-1883	14	5	many	many	ADJ
fcis-1883	14	6	articles	article	NOUN
fcis-1883	14	7	in	in	ADP
fcis-1883	14	8	the	the	DET
fcis-1883	14	9	cardiovascular	cardiovascular	ADJ
fcis-1883	14	10	field	field	NOUN
fcis-1883	14	11	have	have	AUX
fcis-1883	14	12	indicated	indicate	VERB
fcis-1883	14	13	that	that	SCONJ
fcis-1883	14	14	calcium	calcium	NOUN
fcis-1883	14	15	overload	overload	NOUN
fcis-1883	14	16	is	be	AUX
fcis-1883	14	17	not	not	PART
fcis-1883	14	18	only	only	ADV
fcis-1883	14	19	the	the	DET
fcis-1883	14	20	main	main	ADJ
fcis-1883	14	21	inducement	inducement	NOUN
fcis-1883	14	22	of	of	ADP
fcis-1883	14	23	reperfusion	reperfusion	NOUN
fcis-1883	14	24	injury	injury	NOUN
fcis-1883	14	25	,	,	PUNCT
fcis-1883	14	26	but	but	CCONJ
fcis-1883	14	27	also	also	ADV
fcis-1883	14	28	can	can	AUX
fcis-1883	14	29	promote	promote	VERB
fcis-1883	14	30	other	other	ADJ
fcis-1883	14	31	inducing	induce	VERB
fcis-1883	14	32	mechanisms	mechanism	NOUN
fcis-1883	14	33	,	,	PUNCT
fcis-1883	14	34	such	such	ADJ
fcis-1883	14	35	as	as	ADP
fcis-1883	14	36	mitochondrial	mitochondrial	ADJ
fcis-1883	14	37	dysfunction	dysfunction	NOUN
fcis-1883	14	38	,	,	PUNCT
fcis-1883	14	39	oxidative	oxidative	ADJ
fcis-1883	14	40	stress	stress	NOUN
fcis-1883	14	41	response	response	NOUN
fcis-1883	14	42	,	,	PUNCT
fcis-1883	14	43	etc	etc	X
fcis-1883	14	44	.	.	X
fcis-1883	15	1	it	it	PRON
fcis-1883	15	2	can	can	AUX
fcis-1883	15	3	be	be	AUX
fcis-1883	15	4	seen	see	VERB
fcis-1883	15	5	that	that	SCONJ
fcis-1883	15	6	calcium	calcium	NOUN
fcis-1883	15	7	overload	overload	NOUN
fcis-1883	15	8	plays	play	VERB
fcis-1883	15	9	an	an	DET
fcis-1883	15	10	important	important	ADJ
fcis-1883	15	11	role	role	NOUN
fcis-1883	15	12	in	in	ADP
fcis-1883	15	13	the	the	DET
fcis-1883	15	14	occurrence	occurrence	NOUN
fcis-1883	15	15	and	and	CCONJ
fcis-1883	15	16	development	development	NOUN
fcis-1883	15	17	of	of	ADP
fcis-1883	15	18	miri	miri	PROPN
fcis-1883	15	19	.	.	PUNCT
fcis-1883	16	1	based	base	VERB
fcis-1883	16	2	on	on	ADP
fcis-1883	16	3	the	the	DET
fcis-1883	16	4	recent	recent	ADJ
fcis-1883	16	5	research	research	NOUN
fcis-1883	16	6	on	on	ADP
fcis-1883	16	7	the	the	DET
fcis-1883	16	8	mechanism	mechanism	NOUN
fcis-1883	16	9	of	of	ADP
fcis-1883	16	10	mi	mi	PROPN
fcis-1883	16	11	-	-	PROPN
fcis-1883	16	12	ri	ri	PROPN
fcis-1883	16	13	and	and	CCONJ
fcis-1883	16	14	the	the	DET
fcis-1883	16	15	effective	effective	ADJ
fcis-1883	16	16	measures	measure	NOUN
fcis-1883	16	17	to	to	PART
fcis-1883	16	18	reduce	reduce	VERB
fcis-1883	16	19	mi	mi	PROPN
fcis-1883	16	20	-	-	PROPN
fcis-1883	16	21	ri	ri	NOUN
fcis-1883	16	22	,	,	PUNCT
fcis-1883	16	23	this	this	DET
fcis-1883	16	24	paper	paper	NOUN
fcis-1883	16	25	summarizes	summarize	VERB
fcis-1883	16	26	the	the	DET
fcis-1883	16	27	relevant	relevant	ADJ
fcis-1883	16	28	research	research	NOUN
fcis-1883	16	29	materials	material	NOUN
fcis-1883	16	30	on	on	ADP
fcis-1883	16	31	mi	mi	PROPN
fcis-1883	16	32	-	-	PROPN
fcis-1883	16	33	ri	ri	NOUN
fcis-1883	16	34	,	,	PUNCT
fcis-1883	16	35	and	and	CCONJ
fcis-1883	16	36	provides	provide	VERB
fcis-1883	16	37	convenience	convenience	NOUN
fcis-1883	16	38	for	for	SCONJ
fcis-1883	16	39	chinese	chinese	ADJ
fcis-1883	16	40	people	people	NOUN
fcis-1883	16	41	to	to	PART
fcis-1883	16	42	carry	carry	VERB
fcis-1883	16	43	out	out	ADP
fcis-1883	16	44	the	the	DET
fcis-1883	16	45	research	research	NOUN
fcis-1883	16	46	on	on	ADP
fcis-1883	16	47	the	the	DET
fcis-1883	16	48	occurrence	occurrence	NOUN
fcis-1883	16	49	mechanism	mechanism	NOUN
fcis-1883	16	50	and	and	CCONJ
fcis-1883	16	51	protection	protection	NOUN
fcis-1883	16	52	mechanism	mechanism	NOUN
fcis-1883	16	53	of	of	ADP
fcis-1883	16	54	mi	mi	PROPN
fcis-1883	16	55	-	-	PROPN
fcis-1883	16	56	ri	ri	NOUN
fcis-1883	16	57	.	.	PROPN
fcis-1883	16	58	2	2	NUM
fcis-1883	16	59	.	.	X
fcis-1883	17	1	the	the	DET
fcis-1883	17	2	mechanism	mechanism	NOUN
fcis-1883	17	3	of	of	ADP
fcis-1883	17	4	calcium	calcium	NOUN
fcis-1883	17	5	overload	overload	NOUN
fcis-1883	17	6	in	in	ADP
fcis-1883	17	7	cardiomyocytes	cardiomyocyte	NOUN
fcis-1883	17	8	2.1	2.1	NUM
fcis-1883	17	9	.	.	PUNCT
fcis-1883	18	1	na	na	NOUN
fcis-1883	18	2	-	-	PUNCT
fcis-1883	18	3	h	h	NOUN
fcis-1883	18	4	exchanger	exchanger	NOUN
fcis-1883	18	5	(	(	PUNCT
fcis-1883	18	6	nhe	nhe	NOUN
fcis-1883	18	7	)	)	PUNCT
fcis-1883	18	8	as	as	SCONJ
fcis-1883	18	9	the	the	DET
fcis-1883	18	10	name	name	NOUN
fcis-1883	18	11	implies	imply	VERB
fcis-1883	18	12	,	,	PUNCT
fcis-1883	18	13	sodium	sodium	NOUN
fcis-1883	18	14	hydrogen	hydrogen	NOUN
fcis-1883	18	15	exchanger	exchanger	NOUN
fcis-1883	18	16	is	be	AUX
fcis-1883	18	17	an	an	DET
fcis-1883	18	18	ion	ion	NOUN
fcis-1883	18	19	transport	transport	NOUN
fcis-1883	18	20	protein	protein	NOUN
fcis-1883	18	21	located	locate	VERB
fcis-1883	18	22	on	on	ADP
fcis-1883	18	23	the	the	DET
fcis-1883	18	24	cell	cell	NOUN
fcis-1883	18	25	membrane	membrane	NOUN
fcis-1883	18	26	that	that	PRON
fcis-1883	18	27	can	can	AUX
fcis-1883	18	28	exchange	exchange	VERB
fcis-1883	18	29	hydrogen	hydrogen	NOUN
fcis-1883	18	30	ions	ion	NOUN
fcis-1883	18	31	and	and	CCONJ
fcis-1883	18	32	sodium	sodium	NOUN
fcis-1883	18	33	ions	ion	NOUN
fcis-1883	18	34	in	in	ADP
fcis-1883	18	35	equal	equal	ADJ
fcis-1883	18	36	amounts	amount	NOUN
fcis-1883	18	37	.	.	PUNCT
fcis-1883	19	1	its	its	PRON
fcis-1883	19	2	main	main	ADJ
fcis-1883	19	3	role	role	NOUN
fcis-1883	19	4	is	be	AUX
fcis-1883	19	5	to	to	PART
fcis-1883	19	6	maintain	maintain	VERB
fcis-1883	19	7	the	the	DET
fcis-1883	19	8	ph	ph	ADJ
fcis-1883	19	9	stability	stability	NOUN
fcis-1883	19	10	of	of	ADP
fcis-1883	19	11	cells	cell	NOUN
fcis-1883	19	12	.	.	PUNCT
fcis-1883	20	1	during	during	ADP
fcis-1883	20	2	myocardial	myocardial	ADJ
fcis-1883	20	3	ischemia	ischemia	NOUN
fcis-1883	20	4	,	,	PUNCT
fcis-1883	20	5	the	the	DET
fcis-1883	20	6	ischemic	ischemic	ADJ
fcis-1883	20	7	cells	cell	NOUN
fcis-1883	20	8	perform	perform	VERB
fcis-1883	20	9	anaerobic	anaerobic	ADJ
fcis-1883	20	10	respiration	respiration	NOUN
fcis-1883	20	11	due	due	ADP
fcis-1883	20	12	to	to	ADP
fcis-1883	20	13	insufficient	insufficient	ADJ
fcis-1883	20	14	oxygen	oxygen	NOUN
fcis-1883	20	15	supply	supply	NOUN
fcis-1883	20	16	,	,	PUNCT
fcis-1883	20	17	and	and	CCONJ
fcis-1883	20	18	generate	generate	VERB
fcis-1883	20	19	a	a	DET
fcis-1883	20	20	large	large	ADJ
fcis-1883	20	21	amount	amount	NOUN
fcis-1883	20	22	of	of	ADP
fcis-1883	20	23	h+	h+	PUNCT
fcis-1883	20	24	to	to	PART
fcis-1883	20	25	accumulate	accumulate	VERB
fcis-1883	20	26	in	in	ADP
fcis-1883	20	27	the	the	DET
fcis-1883	20	28	cells	cell	NOUN
fcis-1883	20	29	,	,	PUNCT
fcis-1883	20	30	leading	lead	VERB
fcis-1883	20	31	to	to	ADP
fcis-1883	20	32	cell	cell	NOUN
fcis-1883	20	33	acidosis	acidosi	NOUN
fcis-1883	20	34	[	[	X
fcis-1883	20	35	3	3	NUM
fcis-1883	20	36	]	]	X
fcis-1883	20	37	;	;	PUNCT
fcis-1883	20	38	when	when	SCONJ
fcis-1883	20	39	the	the	DET
fcis-1883	20	40	blood	blood	NOUN
fcis-1883	20	41	is	be	AUX
fcis-1883	20	42	reperfusion	reperfusion	NOUN
fcis-1883	20	43	,	,	PUNCT
fcis-1883	20	44	the	the	DET
fcis-1883	20	45	blood	blood	NOUN
fcis-1883	20	46	flow	flow	NOUN
fcis-1883	20	47	takes	take	VERB
fcis-1883	20	48	away	away	ADV
fcis-1883	20	49	the	the	DET
fcis-1883	20	50	h+	h+	PUNCT
fcis-1883	20	51	accumulated	accumulate	VERB
fcis-1883	20	52	during	during	ADP
fcis-1883	20	53	the	the	DET
fcis-1883	20	54	extracellular	extracellular	ADJ
fcis-1883	20	55	ischemia	ischemia	NOUN
fcis-1883	20	56	,	,	PUNCT
fcis-1883	20	57	which	which	PRON
fcis-1883	20	58	makes	make	VERB
fcis-1883	20	59	the	the	DET
fcis-1883	20	60	ph	ph	NOUN
fcis-1883	20	61	of	of	ADP
fcis-1883	20	62	the	the	DET
fcis-1883	20	63	extracellular	extracellular	ADJ
fcis-1883	20	64	fluid	fluid	NOUN
fcis-1883	20	65	rise	rise	NOUN
fcis-1883	20	66	rapidly	rapidly	ADV
fcis-1883	20	67	.	.	PUNCT
fcis-1883	21	1	under	under	ADP
fcis-1883	21	2	the	the	DET
fcis-1883	21	3	combined	combine	VERB
fcis-1883	21	4	action	action	NOUN
fcis-1883	21	5	of	of	ADP
fcis-1883	21	6	the	the	DET
fcis-1883	21	7	two	two	NUM
fcis-1883	21	8	mechanisms	mechanism	NOUN
fcis-1883	21	9	,	,	PUNCT
fcis-1883	21	10	the	the	DET
fcis-1883	21	11	ph	ph	ADJ
fcis-1883	21	12	gradient	gradient	NOUN
fcis-1883	21	13	on	on	ADP
fcis-1883	21	14	both	both	DET
fcis-1883	21	15	sides	side	NOUN
fcis-1883	21	16	of	of	ADP
fcis-1883	21	17	the	the	DET
fcis-1883	21	18	cell	cell	NOUN
fcis-1883	21	19	membrane	membrane	NOUN
fcis-1883	21	20	further	further	ADJ
fcis-1883	21	21	increases	increase	NOUN
fcis-1883	21	22	,	,	PUNCT
fcis-1883	21	23	rapidly	rapidly	ADV
fcis-1883	21	24	activating	activate	VERB
fcis-1883	21	25	the	the	DET
fcis-1883	21	26	sodium	sodium	NOUN
fcis-1883	21	27	hydrogen	hydrogen	NOUN
fcis-1883	21	28	exchanger	exchanger	NOUN
fcis-1883	21	29	.	.	PUNCT
fcis-1883	22	1	with	with	ADP
fcis-1883	22	2	the	the	DET
fcis-1883	22	3	massive	massive	ADJ
fcis-1883	22	4	inflow	inflow	NOUN
fcis-1883	22	5	of	of	ADP
fcis-1883	22	6	sodium	sodium	NOUN
fcis-1883	22	7	ions	ion	NOUN
fcis-1883	22	8	,	,	PUNCT
fcis-1883	22	9	the	the	DET
fcis-1883	22	10	sodium	sodium	NOUN
fcis-1883	22	11	gradient	gradient	NOUN
fcis-1883	22	12	difference	difference	NOUN
fcis-1883	22	13	formed	form	VERB
fcis-1883	22	14	inside	inside	ADP
fcis-1883	22	15	and	and	CCONJ
fcis-1883	22	16	outside	outside	ADP
fcis-1883	22	17	the	the	DET
fcis-1883	22	18	cell	cell	NOUN
fcis-1883	22	19	expands	expand	VERB
fcis-1883	22	20	and	and	CCONJ
fcis-1883	22	21	activates	activate	VERB
fcis-1883	22	22	the	the	DET
fcis-1883	22	23	reverse	reverse	ADJ
fcis-1883	22	24	transport	transport	NOUN
fcis-1883	22	25	of	of	ADP
fcis-1883	22	26	sodium	sodium	NOUN
fcis-1883	22	27	calcium	calcium	NOUN
fcis-1883	22	28	exchanger	exchanger	NOUN
fcis-1883	22	29	protein	protein	NOUN
fcis-1883	22	30	,	,	PUNCT
fcis-1883	22	31	which	which	PRON
fcis-1883	22	32	can	can	AUX
fcis-1883	22	33	eventually	eventually	ADV
fcis-1883	22	34	cause	cause	VERB
fcis-1883	22	35	the	the	DET
fcis-1883	22	36	accumulation	accumulation	NOUN
fcis-1883	22	37	of	of	ADP
fcis-1883	22	38	calcium	calcium	NOUN
fcis-1883	22	39	ions	ion	NOUN
fcis-1883	22	40	in	in	ADP
fcis-1883	22	41	the	the	DET
fcis-1883	22	42	cell	cell	NOUN
fcis-1883	22	43	,	,	PUNCT
fcis-1883	22	44	namely	namely	ADV
fcis-1883	22	45	calcium	calcium	NOUN
fcis-1883	22	46	overload	overload	NOUN
fcis-1883	22	47	.	.	PUNCT
fcis-1883	23	1	the	the	DET
fcis-1883	23	2	article	article	NOUN
fcis-1883	23	3	published	publish	VERB
fcis-1883	23	4	by	by	ADP
fcis-1883	23	5	inserte	inserte	NOUN
fcis-1883	23	6	et	et	PROPN
fcis-1883	23	7	al	al	PROPN
fcis-1883	23	8	.	.	PROPN
fcis-1883	23	9	mentioned	mention	VERB
fcis-1883	23	10	the	the	DET
fcis-1883	23	11	following	follow	VERB
fcis-1883	23	12	viewpoint	viewpoint	NOUN
fcis-1883	23	13	:	:	PUNCT
fcis-1883	23	14	after	after	ADP
fcis-1883	23	15	myocardial	myocardial	ADJ
fcis-1883	23	16	ischemia	ischemia	NOUN
fcis-1883	23	17	,	,	PUNCT
fcis-1883	23	18	the	the	DET
fcis-1883	23	19	body	body	NOUN
fcis-1883	23	20	will	will	AUX
fcis-1883	23	21	stimulate	stimulate	VERB
fcis-1883	23	22	cgmp	cgmp	PROPN
fcis-1883	23	23	/	/	SYM
fcis-1883	23	24	pkg	pkg	NOUN
fcis-1883	23	25	pathway	pathway	NOUN
fcis-1883	23	26	,	,	PUNCT
fcis-1883	23	27	which	which	PRON
fcis-1883	23	28	can	can	AUX
fcis-1883	23	29	reduce	reduce	VERB
fcis-1883	23	30	myocardial	myocardial	ADJ
fcis-1883	23	31	ischemia	ischemia	NOUN
fcis-1883	23	32	reperfusion	reperfusion	NOUN
fcis-1883	23	33	injury	injury	NOUN
fcis-1883	23	34	by	by	ADP
fcis-1883	23	35	inhibiting	inhibit	VERB
fcis-1883	23	36	sodium	sodium	NOUN
fcis-1883	23	37	hydrogen	hydrogen	NOUN
fcis-1883	23	38	exchanger	exchanger	NOUN
fcis-1883	23	39	[	[	X
fcis-1883	23	40	4	4	NUM
fcis-1883	23	41	]	]	PUNCT
fcis-1883	23	42	.	.	PUNCT
fcis-1883	24	1	michiel	michiel	PROPN
fcis-1883	24	2	ten	ten	NUM
fcis-1883	24	3	hove	hove	PROPN
fcis-1883	24	4	et	et	PROPN
fcis-1883	24	5	al	al	PROPN
fcis-1883	24	6	.	.	PUNCT
fcis-1883	25	1	[	[	X
fcis-1883	25	2	5	5	NUM
fcis-1883	25	3	]	]	PUNCT
fcis-1883	25	4	made	make	VERB
fcis-1883	25	5	myocardial	myocardial	ADJ
fcis-1883	25	6	ischemia	ischemia	NOUN
fcis-1883	25	7	model	model	NOUN
fcis-1883	25	8	in	in	ADP
fcis-1883	25	9	mice	mouse	NOUN
fcis-1883	25	10	to	to	PART
fcis-1883	25	11	verify	verify	VERB
fcis-1883	25	12	the	the	DET
fcis-1883	25	13	effect	effect	NOUN
fcis-1883	25	14	of	of	ADP
fcis-1883	25	15	nhe	nhe	NOUN
fcis-1883	25	16	inhibitor	inhibitor	NOUN
fcis-1883	25	17	on	on	ADP
fcis-1883	25	18	reperfusion	reperfusion	NOUN
fcis-1883	25	19	injury	injury	NOUN
fcis-1883	25	20	.	.	PUNCT
fcis-1883	26	1	the	the	DET
fcis-1883	26	2	results	result	NOUN
fcis-1883	26	3	showed	show	VERB
fcis-1883	26	4	that	that	SCONJ
fcis-1883	26	5	nhe	nhe	NOUN
fcis-1883	26	6	inhibitors	inhibitor	NOUN
fcis-1883	26	7	could	could	AUX
fcis-1883	26	8	reduce	reduce	VERB
fcis-1883	26	9	the	the	DET
fcis-1883	26	10	ischemic	ischemic	ADJ
fcis-1883	26	11	sodium	sodium	NOUN
fcis-1883	26	12	overload	overload	NOUN
fcis-1883	26	13	by	by	ADP
fcis-1883	26	14	blocking	block	VERB
fcis-1883	26	15	nhe	nhe	NOUN
fcis-1883	26	16	,	,	PUNCT
fcis-1883	26	17	thereby	thereby	ADV
fcis-1883	26	18	reducing	reduce	VERB
fcis-1883	26	19	the	the	DET
fcis-1883	26	20	intracellular	intracellular	ADJ
fcis-1883	26	21	ca2	ca2	PROPN
fcis-1883	26	22	+	+	NOUN
fcis-1883	26	23	concentration	concentration	NOUN
fcis-1883	26	24	,	,	PUNCT
fcis-1883	26	25	and	and	CCONJ
fcis-1883	26	26	ultimately	ultimately	ADV
fcis-1883	26	27	reducing	reduce	VERB
fcis-1883	26	28	the	the	DET
fcis-1883	26	29	heart	heart	NOUN
fcis-1883	26	30	damage	damage	NOUN
fcis-1883	26	31	.	.	PUNCT
fcis-1883	27	1	therefore	therefore	ADV
fcis-1883	27	2	,	,	PUNCT
fcis-1883	27	3	we	we	PRON
fcis-1883	27	4	can	can	AUX
fcis-1883	27	5	conclude	conclude	VERB
fcis-1883	27	6	that	that	DET
fcis-1883	27	7	sodium	sodium	NOUN
fcis-1883	27	8	hydrogen	hydrogen	NOUN
fcis-1883	27	9	exchanger	exchanger	NOUN
fcis-1883	27	10	is	be	AUX
fcis-1883	27	11	an	an	DET
fcis-1883	27	12	important	important	ADJ
fcis-1883	27	13	part	part	NOUN
fcis-1883	27	14	of	of	ADP
fcis-1883	27	15	calcium	calcium	NOUN
fcis-1883	27	16	overload	overload	NOUN
fcis-1883	27	17	mechanism	mechanism	NOUN
fcis-1883	27	18	,	,	PUNCT
fcis-1883	27	19	and	and	CCONJ
fcis-1883	27	20	we	we	PRON
fcis-1883	27	21	can	can	AUX
fcis-1883	27	22	reduce	reduce	VERB
fcis-1883	27	23	reperfusion	reperfusion	NOUN
fcis-1883	27	24	injury	injury	NOUN
fcis-1883	27	25	through	through	ADP
fcis-1883	27	26	it	it	PRON
fcis-1883	27	27	.	.	PUNCT
fcis-1883	28	1	75	75	NUM
fcis-1883	28	2	2.2	2.2	NUM
fcis-1883	28	3	.	.	PUNCT
fcis-1883	28	4	sodium	sodium	NOUN
fcis-1883	28	5	calcium	calcium	NOUN
fcis-1883	28	6	exchange	exchange	NOUN
fcis-1883	28	7	protein	protein	NOUN
fcis-1883	28	8	(	(	PUNCT
fcis-1883	28	9	ncx	ncx	NOUN
fcis-1883	28	10	)	)	PUNCT
fcis-1883	28	11	under	under	ADP
fcis-1883	28	12	normal	normal	ADJ
fcis-1883	28	13	physiological	physiological	ADJ
fcis-1883	28	14	conditions	condition	NOUN
fcis-1883	28	15	,	,	PUNCT
fcis-1883	28	16	sodium	sodium	NOUN
fcis-1883	28	17	calcium	calcium	NOUN
fcis-1883	28	18	exchange	exchange	NOUN
fcis-1883	28	19	proteins	protein	NOUN
fcis-1883	28	20	transfer	transfer	NOUN
fcis-1883	28	21	sodium	sodium	NOUN
fcis-1883	28	22	ions	ion	NOUN
fcis-1883	28	23	into	into	ADP
fcis-1883	28	24	cells	cell	NOUN
fcis-1883	28	25	and	and	CCONJ
fcis-1883	28	26	calcium	calcium	NOUN
fcis-1883	28	27	ions	ion	NOUN
fcis-1883	28	28	out	out	ADP
fcis-1883	28	29	of	of	ADP
fcis-1883	28	30	cells	cell	NOUN
fcis-1883	28	31	,	,	PUNCT
fcis-1883	28	32	and	and	CCONJ
fcis-1883	28	33	the	the	DET
fcis-1883	28	34	transport	transport	NOUN
fcis-1883	28	35	ratio	ratio	NOUN
fcis-1883	28	36	is	be	AUX
fcis-1883	28	37	3:1	3:1	NUM
fcis-1883	28	38	.	.	PUNCT
fcis-1883	29	1	its	its	PRON
fcis-1883	29	2	main	main	ADJ
fcis-1883	29	3	function	function	NOUN
fcis-1883	29	4	is	be	AUX
fcis-1883	29	5	to	to	PART
fcis-1883	29	6	use	use	VERB
fcis-1883	29	7	the	the	DET
fcis-1883	29	8	sodium	sodium	NOUN
fcis-1883	29	9	concentration	concentration	NOUN
fcis-1883	29	10	gradient	gradient	NOUN
fcis-1883	29	11	potential	potential	ADJ
fcis-1883	29	12	energy	energy	NOUN
fcis-1883	29	13	on	on	ADP
fcis-1883	29	14	both	both	DET
fcis-1883	29	15	sides	side	NOUN
fcis-1883	29	16	of	of	ADP
fcis-1883	29	17	the	the	DET
fcis-1883	29	18	membrane	membrane	NOUN
fcis-1883	29	19	established	establish	VERB
fcis-1883	29	20	by	by	ADP
fcis-1883	29	21	the	the	DET
fcis-1883	29	22	sodium	sodium	NOUN
fcis-1883	29	23	pump	pump	NOUN
fcis-1883	29	24	activity	activity	NOUN
fcis-1883	29	25	to	to	PART
fcis-1883	29	26	expel	expel	VERB
fcis-1883	29	27	calcium	calcium	NOUN
fcis-1883	29	28	ions	ion	NOUN
fcis-1883	29	29	from	from	ADP
fcis-1883	29	30	the	the	DET
fcis-1883	29	31	cells	cell	NOUN
fcis-1883	29	32	,	,	PUNCT
fcis-1883	29	33	so	so	SCONJ
fcis-1883	29	34	as	as	SCONJ
fcis-1883	29	35	to	to	PART
fcis-1883	29	36	maintain	maintain	VERB
fcis-1883	29	37	a	a	DET
fcis-1883	29	38	low	low	ADJ
fcis-1883	29	39	concentration	concentration	NOUN
fcis-1883	29	40	of	of	ADP
fcis-1883	29	41	free	free	ADJ
fcis-1883	29	42	calcium	calcium	NOUN
fcis-1883	29	43	ions	ion	NOUN
fcis-1883	29	44	in	in	ADP
fcis-1883	29	45	the	the	DET
fcis-1883	29	46	cells	cell	NOUN
fcis-1883	29	47	.	.	PUNCT
fcis-1883	30	1	however	however	ADV
fcis-1883	30	2	,	,	PUNCT
fcis-1883	30	3	when	when	SCONJ
fcis-1883	30	4	sodium	sodium	NOUN
fcis-1883	30	5	hydrogen	hydrogen	NOUN
fcis-1883	30	6	exchanger	exchanger	NOUN
fcis-1883	30	7	is	be	AUX
fcis-1883	30	8	activated	activate	VERB
fcis-1883	30	9	and	and	CCONJ
fcis-1883	30	10	sodium	sodium	NOUN
fcis-1883	30	11	potassium	potassium	NOUN
fcis-1883	30	12	atpase	atpase	NOUN
fcis-1883	30	13	dysfunction	dysfunction	NOUN
fcis-1883	30	14	is	be	AUX
fcis-1883	30	15	caused	cause	VERB
fcis-1883	30	16	by	by	ADP
fcis-1883	30	17	insufficient	insufficient	ADJ
fcis-1883	30	18	energy	energy	NOUN
fcis-1883	30	19	supply	supply	NOUN
fcis-1883	30	20	due	due	ADP
fcis-1883	30	21	to	to	ADP
fcis-1883	30	22	myocardial	myocardial	ADJ
fcis-1883	30	23	ischemia	ischemia	NOUN
fcis-1883	30	24	,	,	PUNCT
fcis-1883	30	25	the	the	DET
fcis-1883	30	26	intracellular	intracellular	ADJ
fcis-1883	30	27	sodium	sodium	NOUN
fcis-1883	30	28	concentration	concentration	NOUN
fcis-1883	30	29	increases	increase	VERB
fcis-1883	30	30	significantly	significantly	ADV
fcis-1883	30	31	,	,	PUNCT
fcis-1883	30	32	leading	lead	VERB
fcis-1883	30	33	to	to	ADP
fcis-1883	30	34	the	the	DET
fcis-1883	30	35	activation	activation	NOUN
fcis-1883	30	36	of	of	ADP
fcis-1883	30	37	reverse	reverse	ADJ
fcis-1883	30	38	sodium	sodium	NOUN
fcis-1883	30	39	calcium	calcium	NOUN
fcis-1883	30	40	exchanger	exchanger	NOUN
fcis-1883	30	41	and	and	CCONJ
fcis-1883	30	42	the	the	DET
fcis-1883	30	43	pathological	pathological	ADJ
fcis-1883	30	44	state	state	NOUN
fcis-1883	30	45	of	of	ADP
fcis-1883	30	46	calcium	calcium	NOUN
fcis-1883	30	47	overload	overload	NOUN
fcis-1883	30	48	[	[	X
fcis-1883	30	49	6	6	NUM
fcis-1883	30	50	]	]	PUNCT
fcis-1883	30	51	.	.	PUNCT
fcis-1883	31	1	maddaford	maddaford	NOUN
fcis-1883	31	2	et	et	PROPN
fcis-1883	31	3	al	al	PROPN
fcis-1883	31	4	.	.	PUNCT
fcis-1883	32	1	[	[	X
fcis-1883	32	2	7	7	X
fcis-1883	32	3	]	]	PUNCT
fcis-1883	32	4	designed	design	VERB
fcis-1883	32	5	the	the	DET
fcis-1883	32	6	experiment	experiment	NOUN
fcis-1883	32	7	by	by	ADP
fcis-1883	32	8	cloning	clone	VERB
fcis-1883	32	9	shrna	shrna	NOUN
fcis-1883	32	10	into	into	ADP
fcis-1883	32	11	adult	adult	NOUN
fcis-1883	32	12	rat	rat	NOUN
fcis-1883	32	13	cardiomyocytes	cardiomyocyte	NOUN
fcis-1883	32	14	through	through	ADP
fcis-1883	32	15	adenovirus	adenovirus	NOUN
fcis-1883	32	16	mediated	mediate	VERB
fcis-1883	32	17	cloning	cloning	NOUN
fcis-1883	32	18	to	to	PART
fcis-1883	32	19	reduce	reduce	VERB
fcis-1883	32	20	the	the	DET
fcis-1883	32	21	expression	expression	NOUN
fcis-1883	32	22	of	of	ADP
fcis-1883	32	23	sodium	sodium	NOUN
fcis-1883	32	24	calcium	calcium	NOUN
fcis-1883	32	25	exchange	exchange	NOUN
fcis-1883	32	26	protein	protein	NOUN
fcis-1883	32	27	(	(	PUNCT
fcis-1883	32	28	ncx	ncx	NOUN
fcis-1883	32	29	)	)	PUNCT
fcis-1883	32	30	.	.	PUNCT
fcis-1883	33	1	when	when	SCONJ
fcis-1883	33	2	the	the	DET
fcis-1883	33	3	treated	treat	VERB
fcis-1883	33	4	cardiomyocytes	cardiomyocyte	NOUN
fcis-1883	33	5	are	be	AUX
fcis-1883	33	6	exposed	expose	VERB
fcis-1883	33	7	to	to	ADP
fcis-1883	33	8	simulated	simulate	VERB
fcis-1883	33	9	ischemia	ischemia	NOUN
fcis-1883	33	10	solution	solution	NOUN
fcis-1883	33	11	,	,	PUNCT
fcis-1883	33	12	they	they	PRON
fcis-1883	33	13	will	will	AUX
fcis-1883	33	14	be	be	AUX
fcis-1883	33	15	protected	protect	VERB
fcis-1883	33	16	from	from	ADP
fcis-1883	33	17	the	the	DET
fcis-1883	33	18	increase	increase	NOUN
fcis-1883	33	19	and	and	CCONJ
fcis-1883	33	20	damage	damage	NOUN
fcis-1883	33	21	of	of	ADP
fcis-1883	33	22	cytoplasmic	cytoplasmic	ADJ
fcis-1883	33	23	ca2	ca2	PROPN
fcis-1883	33	24	+	+	CCONJ
fcis-1883	33	25	detected	detect	VERB
fcis-1883	33	26	in	in	ADP
fcis-1883	33	27	control	control	NOUN
fcis-1883	33	28	normal	normal	ADJ
fcis-1883	33	29	cells	cell	NOUN
fcis-1883	33	30	during	during	ADP
fcis-1883	33	31	ischemia	ischemia	NOUN
fcis-1883	33	32	and	and	CCONJ
fcis-1883	33	33	reperfusion	reperfusion	NOUN
fcis-1883	33	34	,	,	PUNCT
fcis-1883	33	35	indicating	indicate	VERB
fcis-1883	33	36	that	that	SCONJ
fcis-1883	33	37	cells	cell	NOUN
fcis-1883	33	38	with	with	ADP
fcis-1883	33	39	ncx	ncx	ADJ
fcis-1883	33	40	deficiency	deficiency	NOUN
fcis-1883	33	41	are	be	AUX
fcis-1883	33	42	obviously	obviously	ADV
fcis-1883	33	43	protected	protect	VERB
fcis-1883	33	44	.	.	PUNCT
fcis-1883	34	1	it	it	PRON
fcis-1883	34	2	can	can	AUX
fcis-1883	34	3	be	be	AUX
fcis-1883	34	4	concluded	conclude	VERB
fcis-1883	34	5	that	that	SCONJ
fcis-1883	34	6	ncx	ncx	NOUN
fcis-1883	34	7	of	of	ADP
fcis-1883	34	8	sarcolemma	sarcolemma	PROPN
fcis-1883	34	9	contributes	contribute	VERB
fcis-1883	34	10	to	to	ADP
fcis-1883	34	11	calcium	calcium	NOUN
fcis-1883	34	12	overload	overload	NOUN
fcis-1883	34	13	of	of	ADP
fcis-1883	34	14	cytosol	cytosol	NOUN
fcis-1883	34	15	during	during	ADP
fcis-1883	34	16	iri	iri	PROPN
fcis-1883	34	17	.	.	PROPN
fcis-1883	35	1	2.3	2.3	NUM
fcis-1883	35	2	.	.	PUNCT
fcis-1883	35	3	calcium	calcium	NOUN
fcis-1883	35	4	pump	pump	NOUN
fcis-1883	35	5	of	of	ADP
fcis-1883	35	6	endoplasmic	endoplasmic	ADJ
fcis-1883	35	7	reticulum	reticulum	NOUN
fcis-1883	35	8	/	/	SYM
fcis-1883	35	9	sarcoplasmic	sarcoplasmic	NOUN
fcis-1883	35	10	reticulum	reticulum	NOUN
fcis-1883	35	11	(	(	PUNCT
fcis-1883	35	12	er	er	INTJ
fcis-1883	35	13	/	/	SYM
fcis-1883	35	14	sr	sr	PROPN
fcis-1883	35	15	serca	serca	PROPN
fcis-1883	35	16	)	)	PUNCT
fcis-1883	35	17	serca	serca	PROPN
fcis-1883	35	18	is	be	AUX
fcis-1883	35	19	a	a	DET
fcis-1883	35	20	transmembrane	transmembrane	ADJ
fcis-1883	35	21	transport	transport	NOUN
fcis-1883	35	22	protein	protein	NOUN
fcis-1883	35	23	rich	rich	ADJ
fcis-1883	35	24	in	in	ADP
fcis-1883	35	25	sarcoplasmic	sarcoplasmic	ADJ
fcis-1883	35	26	reticulum	reticulum	NOUN
fcis-1883	35	27	,	,	PUNCT
fcis-1883	35	28	which	which	PRON
fcis-1883	35	29	plays	play	VERB
fcis-1883	35	30	an	an	DET
fcis-1883	35	31	important	important	ADJ
fcis-1883	35	32	role	role	NOUN
fcis-1883	35	33	in	in	ADP
fcis-1883	35	34	the	the	DET
fcis-1883	35	35	regulation	regulation	NOUN
fcis-1883	35	36	of	of	ADP
fcis-1883	35	37	calcium	calcium	NOUN
fcis-1883	35	38	homeostasis	homeostasis	NOUN
fcis-1883	35	39	in	in	ADP
fcis-1883	35	40	cardiomyocytes	cardiomyocyte	NOUN
fcis-1883	35	41	.	.	PUNCT
fcis-1883	36	1	serca	serca	PROPN
fcis-1883	36	2	belongs	belong	VERB
fcis-1883	36	3	to	to	ADP
fcis-1883	36	4	the	the	DET
fcis-1883	36	5	p	p	ADJ
fcis-1883	36	6	-	-	PUNCT
fcis-1883	36	7	type	type	NOUN
fcis-1883	36	8	pump	pump	NOUN
fcis-1883	36	9	,	,	PUNCT
fcis-1883	36	10	which	which	PRON
fcis-1883	36	11	can	can	AUX
fcis-1883	36	12	pump	pump	VERB
fcis-1883	36	13	ca2	ca2	PROPN
fcis-1883	36	14	+	+	PROPN
fcis-1883	36	15	from	from	ADP
fcis-1883	36	16	the	the	DET
fcis-1883	36	17	cytoplasmic	cytoplasmic	ADJ
fcis-1883	36	18	matrix	matrix	NOUN
fcis-1883	36	19	to	to	ADP
fcis-1883	36	20	the	the	DET
fcis-1883	36	21	sarcoplasmic	sarcoplasmic	NOUN
fcis-1883	36	22	reticulum	reticulum	NOUN
fcis-1883	36	23	using	use	VERB
fcis-1883	36	24	the	the	DET
fcis-1883	36	25	energy	energy	NOUN
fcis-1883	36	26	released	release	VERB
fcis-1883	36	27	by	by	ADP
fcis-1883	36	28	atp	atp	NOUN
fcis-1883	36	29	hydrolysis	hydrolysis	NOUN
fcis-1883	36	30	.	.	PUNCT
fcis-1883	37	1	when	when	SCONJ
fcis-1883	37	2	the	the	DET
fcis-1883	37	3	myocardial	myocardial	ADJ
fcis-1883	37	4	perfusion	perfusion	NOUN
fcis-1883	37	5	is	be	AUX
fcis-1883	37	6	insufficient	insufficient	ADJ
fcis-1883	37	7	,	,	PUNCT
fcis-1883	37	8	there	there	PRON
fcis-1883	37	9	is	be	VERB
fcis-1883	37	10	not	not	PART
fcis-1883	37	11	enough	enough	ADJ
fcis-1883	37	12	energy	energy	NOUN
fcis-1883	37	13	supply	supply	NOUN
fcis-1883	37	14	,	,	PUNCT
fcis-1883	37	15	and	and	CCONJ
fcis-1883	37	16	its	its	PRON
fcis-1883	37	17	active	active	ADJ
fcis-1883	37	18	transport	transport	NOUN
fcis-1883	37	19	ability	ability	NOUN
fcis-1883	37	20	to	to	PART
fcis-1883	37	21	drain	drain	VERB
fcis-1883	37	22	ca	ca	NOUN
fcis-1883	37	23	2	2	NUM
fcis-1883	37	24	+	+	CCONJ
fcis-1883	37	25	from	from	ADP
fcis-1883	37	26	cytoplasm	cytoplasm	NOUN
fcis-1883	37	27	into	into	ADP
fcis-1883	37	28	the	the	DET
fcis-1883	37	29	sarcoplasmic	sarcoplasmic	NOUN
fcis-1883	37	30	reticulum	reticulum	NOUN
fcis-1883	37	31	by	by	ADP
fcis-1883	37	32	consuming	consume	VERB
fcis-1883	37	33	atp	atp	NOUN
fcis-1883	37	34	reverse	reverse	PROPN
fcis-1883	37	35	concentration	concentration	NOUN
fcis-1883	37	36	gradient	gradient	NOUN
fcis-1883	37	37	will	will	AUX
fcis-1883	37	38	be	be	AUX
fcis-1883	37	39	significantly	significantly	ADV
fcis-1883	37	40	reduced	reduce	VERB
fcis-1883	37	41	[	[	X
fcis-1883	37	42	8	8	NUM
fcis-1883	37	43	]	]	PUNCT
fcis-1883	37	44	.	.	PUNCT
fcis-1883	38	1	when	when	SCONJ
fcis-1883	38	2	atp	atp	PROPN
fcis-1883	38	3	concentration	concentration	NOUN
fcis-1883	38	4	reaches	reach	VERB
fcis-1883	38	5	a	a	DET
fcis-1883	38	6	critical	critical	ADJ
fcis-1883	38	7	low	low	ADJ
fcis-1883	38	8	threshold	threshold	NOUN
fcis-1883	38	9	(	(	PUNCT
fcis-1883	38	10	lower	low	ADJ
fcis-1883	38	11	than	than	ADP
fcis-1883	38	12	100mmol	100mmol	PROPN
fcis-1883	38	13	/	/	SYM
fcis-1883	38	14	l	l	NOUN
fcis-1883	38	15	)	)	PUNCT
fcis-1883	38	16	,	,	PUNCT
fcis-1883	38	17	myocardial	myocardial	ADJ
fcis-1883	38	18	cells	cell	NOUN
fcis-1883	38	19	begin	begin	VERB
fcis-1883	38	20	to	to	PART
fcis-1883	38	21	appear	appear	VERB
fcis-1883	38	22	stiff	stiff	ADJ
fcis-1883	38	23	contracture	contracture	NOUN
fcis-1883	38	24	,	,	PUNCT
fcis-1883	38	25	which	which	PRON
fcis-1883	38	26	marks	mark	VERB
fcis-1883	38	27	the	the	DET
fcis-1883	38	28	beginning	beginning	NOUN
fcis-1883	38	29	of	of	ADP
fcis-1883	38	30	the	the	DET
fcis-1883	38	31	increase	increase	NOUN
fcis-1883	38	32	of	of	ADP
fcis-1883	38	33	cytosolic	cytosolic	ADJ
fcis-1883	38	34	ca2	ca2	PROPN
fcis-1883	38	35	+	+	PUNCT
fcis-1883	38	36	and	and	CCONJ
fcis-1883	38	37	represents	represent	VERB
fcis-1883	38	38	a	a	DET
fcis-1883	38	39	key	key	ADJ
fcis-1883	38	40	event	event	NOUN
fcis-1883	38	41	in	in	ADP
fcis-1883	38	42	the	the	DET
fcis-1883	38	43	progress	progress	NOUN
fcis-1883	38	44	of	of	ADP
fcis-1883	38	45	ischemic	ischemic	ADJ
fcis-1883	38	46	injury	injury	NOUN
fcis-1883	39	1	[	[	X
fcis-1883	39	2	9	9	NUM
fcis-1883	39	3	]	]	PUNCT
fcis-1883	39	4	.	.	PUNCT
fcis-1883	40	1	low	low	PROPN
fcis-1883	40	2	atp	atp	PROPN
fcis-1883	40	3	concentration	concentration	NOUN
fcis-1883	40	4	will	will	AUX
fcis-1883	40	5	damage	damage	VERB
fcis-1883	40	6	the	the	DET
fcis-1883	40	7	activities	activity	NOUN
fcis-1883	40	8	of	of	ADP
fcis-1883	40	9	ncx	ncx	NOUN
fcis-1883	40	10	and	and	CCONJ
fcis-1883	40	11	er	er	INTJ
fcis-1883	40	12	/	/	SYM
fcis-1883	40	13	sr	sr	PROPN
fcis-1883	40	14	serca	serca	PROPN
fcis-1883	40	15	in	in	ADP
fcis-1883	40	16	the	the	DET
fcis-1883	40	17	sarcolemma	sarcolemma	NOUN
fcis-1883	40	18	,	,	PUNCT
fcis-1883	40	19	thus	thus	ADV
fcis-1883	40	20	triggering	trigger	VERB
fcis-1883	40	21	cytosolic	cytosolic	ADJ
fcis-1883	40	22	na+	na+	NOUN
fcis-1883	40	23	and	and	CCONJ
fcis-1883	40	24	ca2	ca2	PROPN
fcis-1883	40	25	+	+	PROPN
fcis-1883	40	26	overload	overload	NOUN
fcis-1883	40	27	[	[	X
fcis-1883	40	28	10	10	NUM
fcis-1883	40	29	]	]	PUNCT
fcis-1883	40	30	.	.	PUNCT
fcis-1883	41	1	2.4	2.4	NUM
fcis-1883	41	2	.	.	PUNCT
fcis-1883	42	1	l	l	ADJ
fcis-1883	42	2	-	-	PUNCT
fcis-1883	42	3	type	type	NOUN
fcis-1883	42	4	ca2+channels	ca2+channel	NOUN
fcis-1883	42	5	(	(	PUNCT
fcis-1883	42	6	ltcc	ltcc	ADJ
fcis-1883	42	7	)	)	PUNCT
fcis-1883	42	8	l	l	ADJ
fcis-1883	42	9	-	-	PUNCT
fcis-1883	42	10	type	type	NOUN
fcis-1883	42	11	calcium	calcium	NOUN
fcis-1883	42	12	channel	channel	NOUN
fcis-1883	42	13	is	be	AUX
fcis-1883	42	14	a	a	DET
fcis-1883	42	15	voltage	voltage	NOUN
fcis-1883	42	16	dependent	dependent	ADJ
fcis-1883	42	17	calcium	calcium	NOUN
fcis-1883	42	18	channel	channel	NOUN
fcis-1883	42	19	.	.	PUNCT
fcis-1883	43	1	it	it	PRON
fcis-1883	43	2	can	can	AUX
fcis-1883	43	3	be	be	AUX
fcis-1883	43	4	seen	see	VERB
fcis-1883	43	5	from	from	ADP
fcis-1883	43	6	the	the	DET
fcis-1883	43	7	above	above	ADJ
fcis-1883	43	8	mechanism	mechanism	NOUN
fcis-1883	43	9	that	that	PRON
fcis-1883	43	10	when	when	SCONJ
fcis-1883	43	11	cells	cell	NOUN
fcis-1883	43	12	are	be	AUX
fcis-1883	43	13	ischemic	ischemic	ADJ
fcis-1883	43	14	,	,	PUNCT
fcis-1883	43	15	the	the	DET
fcis-1883	43	16	cell	cell	NOUN
fcis-1883	43	17	membrane	membrane	NOUN
fcis-1883	43	18	potential	potential	NOUN
fcis-1883	43	19	will	will	AUX
fcis-1883	43	20	depolarize	depolarize	VERB
fcis-1883	43	21	,	,	PUNCT
fcis-1883	43	22	and	and	CCONJ
fcis-1883	43	23	then	then	ADV
fcis-1883	43	24	activate	activate	VERB
fcis-1883	43	25	the	the	DET
fcis-1883	43	26	l	l	ADJ
fcis-1883	43	27	-	-	PUNCT
fcis-1883	43	28	type	type	NOUN
fcis-1883	43	29	calcium	calcium	NOUN
fcis-1883	43	30	channel	channel	NOUN
fcis-1883	43	31	to	to	PART
fcis-1883	43	32	open	open	VERB
fcis-1883	43	33	.	.	PUNCT
fcis-1883	44	1	next	next	ADV
fcis-1883	44	2	,	,	PUNCT
fcis-1883	44	3	a	a	DET
fcis-1883	44	4	large	large	ADJ
fcis-1883	44	5	amount	amount	NOUN
fcis-1883	44	6	of	of	ADP
fcis-1883	44	7	calcium	calcium	NOUN
fcis-1883	44	8	ions	ion	NOUN
fcis-1883	44	9	will	will	AUX
fcis-1883	44	10	stimulate	stimulate	VERB
fcis-1883	44	11	another	another	DET
fcis-1883	44	12	synergistic	synergistic	ADJ
fcis-1883	44	13	mechanism	mechanism	NOUN
fcis-1883	44	14	,	,	PUNCT
fcis-1883	44	15	namely	namely	ADV
fcis-1883	44	16	calcium	calcium	NOUN
fcis-1883	44	17	triggered	trigger	VERB
fcis-1883	44	18	calcium	calcium	NOUN
fcis-1883	44	19	release	release	NOUN
fcis-1883	44	20	(	(	PUNCT
fcis-1883	44	21	cicr	cicr	NOUN
fcis-1883	44	22	)	)	PUNCT
fcis-1883	44	23	.	.	PUNCT
fcis-1883	45	1	arreola	arreola	PROPN
fcis-1883	45	2	et	et	PROPN
fcis-1883	45	3	al	al	PROPN
fcis-1883	45	4	.	.	PUNCT
fcis-1883	46	1	[	[	X
fcis-1883	46	2	11	11	NUM
fcis-1883	46	3	]	]	PUNCT
fcis-1883	46	4	described	describe	VERB
fcis-1883	46	5	the	the	DET
fcis-1883	46	6	characteristics	characteristic	NOUN
fcis-1883	46	7	of	of	ADP
fcis-1883	46	8	ca2	ca2	PROPN
fcis-1883	46	9	+	+	PROPN
fcis-1883	46	10	current	current	ADJ
fcis-1883	46	11	in	in	ADP
fcis-1883	46	12	guinea	guinea	NOUN
fcis-1883	46	13	pig	pig	NOUN
fcis-1883	46	14	ventricular	ventricular	ADJ
fcis-1883	46	15	myocytes	myocyte	NOUN
fcis-1883	46	16	using	use	VERB
fcis-1883	46	17	voltage	voltage	NOUN
fcis-1883	46	18	clamp	clamp	NOUN
fcis-1883	46	19	experiment	experiment	NOUN
fcis-1883	46	20	simulating	simulate	VERB
fcis-1883	46	21	physiological	physiological	ADJ
fcis-1883	46	22	action	action	NOUN
fcis-1883	46	23	potential	potential	NOUN
fcis-1883	46	24	.	.	PUNCT
fcis-1883	47	1	the	the	DET
fcis-1883	47	2	ca2	ca2	PROPN
fcis-1883	47	3	+	+	PROPN
fcis-1883	47	4	current	current	ADJ
fcis-1883	47	5	generated	generate	VERB
fcis-1883	47	6	by	by	ADP
fcis-1883	47	7	action	action	NOUN
fcis-1883	47	8	potential	potential	NOUN
fcis-1883	47	9	consists	consist	VERB
fcis-1883	47	10	of	of	ADP
fcis-1883	47	11	l	l	NOUN
fcis-1883	47	12	-	-	NOUN
fcis-1883	47	13	type	type	NOUN
fcis-1883	47	14	and	and	CCONJ
fcis-1883	47	15	t	t	NOUN
fcis-1883	47	16	-	-	PUNCT
fcis-1883	47	17	type	type	NOUN
fcis-1883	47	18	calcium	calcium	NOUN
fcis-1883	47	19	channels	channel	NOUN
fcis-1883	47	20	.	.	PUNCT
fcis-1883	48	1	t	t	NOUN
fcis-1883	48	2	-	-	PUNCT
fcis-1883	48	3	type	type	NOUN
fcis-1883	48	4	calcium	calcium	NOUN
fcis-1883	48	5	current	current	NOUN
fcis-1883	48	6	participates	participate	VERB
fcis-1883	48	7	in	in	ADP
fcis-1883	48	8	the	the	DET
fcis-1883	48	9	fast	fast	ADJ
fcis-1883	48	10	component	component	NOUN
fcis-1883	48	11	of	of	ADP
fcis-1883	48	12	ca2	ca2	PROPN
fcis-1883	48	13	+	+	PROPN
fcis-1883	48	14	current	current	ADJ
fcis-1883	48	15	,	,	PUNCT
fcis-1883	48	16	while	while	SCONJ
fcis-1883	48	17	l	l	ADJ
fcis-1883	48	18	-	-	PUNCT
fcis-1883	48	19	type	type	NOUN
fcis-1883	48	20	calcium	calcium	NOUN
fcis-1883	48	21	current	current	NOUN
fcis-1883	48	22	participates	participate	VERB
fcis-1883	48	23	in	in	ADP
fcis-1883	48	24	the	the	DET
fcis-1883	48	25	fast	fast	ADJ
fcis-1883	48	26	component	component	NOUN
fcis-1883	48	27	and	and	CCONJ
fcis-1883	48	28	slow	slow	ADJ
fcis-1883	48	29	component	component	NOUN
fcis-1883	48	30	of	of	ADP
fcis-1883	48	31	ca2	ca2	PROPN
fcis-1883	48	32	+	+	PROPN
fcis-1883	48	33	current	current	ADJ
fcis-1883	48	34	.	.	PUNCT
fcis-1883	49	1	by	by	ADP
fcis-1883	49	2	measuring	measure	VERB
fcis-1883	49	3	cytosolic	cytosolic	ADJ
fcis-1883	49	4	ca2	ca2	PROPN
fcis-1883	49	5	+	+	PROPN
fcis-1883	49	6	transients	transient	NOUN
fcis-1883	49	7	through	through	ADP
fcis-1883	49	8	fura-2	fura-2	NUM
fcis-1883	49	9	,	,	PUNCT
fcis-1883	49	10	they	they	PRON
fcis-1883	49	11	concluded	conclude	VERB
fcis-1883	49	12	that	that	SCONJ
fcis-1883	49	13	calcium	calcium	NOUN
fcis-1883	49	14	ions	ion	NOUN
fcis-1883	49	15	flowing	flow	VERB
fcis-1883	49	16	into	into	ADP
fcis-1883	49	17	sarcoplasmic	sarcoplasmic	ADJ
fcis-1883	49	18	reticulum	reticulum	NOUN
fcis-1883	49	19	can	can	AUX
fcis-1883	49	20	trigger	trigger	VERB
fcis-1883	49	21	the	the	DET
fcis-1883	49	22	release	release	NOUN
fcis-1883	49	23	of	of	ADP
fcis-1883	49	24	calcium	calcium	NOUN
fcis-1883	49	25	ions	ion	NOUN
fcis-1883	49	26	from	from	ADP
fcis-1883	49	27	sarcoplasmic	sarcoplasmic	ADJ
fcis-1883	49	28	reticulum	reticulum	NOUN
fcis-1883	49	29	when	when	SCONJ
fcis-1883	49	30	l	l	NOUN
fcis-1883	49	31	-	-	PUNCT
fcis-1883	49	32	type	type	NOUN
fcis-1883	49	33	calcium	calcium	NOUN
fcis-1883	49	34	channels	channel	NOUN
fcis-1883	49	35	open	open	VERB
fcis-1883	49	36	.	.	PUNCT
fcis-1883	50	1	in	in	ADP
fcis-1883	50	2	another	another	DET
fcis-1883	50	3	article	article	NOUN
fcis-1883	50	4	[	[	X
fcis-1883	50	5	12	12	NUM
fcis-1883	50	6	]	]	PUNCT
fcis-1883	50	7	,	,	PUNCT
fcis-1883	50	8	the	the	DET
fcis-1883	50	9	mechanism	mechanism	NOUN
fcis-1883	50	10	of	of	ADP
fcis-1883	50	11	sarcoplasmic	sarcoplasmic	ADJ
fcis-1883	50	12	reticulum	reticulum	NOUN
fcis-1883	50	13	releasing	release	VERB
fcis-1883	50	14	calcium	calcium	NOUN
fcis-1883	50	15	ions	ion	NOUN
fcis-1883	50	16	was	be	AUX
fcis-1883	50	17	not	not	PART
fcis-1883	50	18	triggered	trigger	VERB
fcis-1883	50	19	by	by	ADP
fcis-1883	50	20	the	the	DET
fcis-1883	50	21	administration	administration	NOUN
fcis-1883	50	22	of	of	ADP
fcis-1883	50	23	drugs	drug	NOUN
fcis-1883	50	24	to	to	PART
fcis-1883	50	25	reduce	reduce	VERB
fcis-1883	50	26	the	the	DET
fcis-1883	50	27	activity	activity	NOUN
fcis-1883	50	28	of	of	ADP
fcis-1883	50	29	l	l	NOUN
fcis-1883	50	30	-	-	PUNCT
fcis-1883	50	31	type	type	NOUN
fcis-1883	50	32	calcium	calcium	NOUN
fcis-1883	50	33	channel	channel	NOUN
fcis-1883	50	34	,	,	PUNCT
fcis-1883	50	35	thus	thus	ADV
fcis-1883	50	36	the	the	DET
fcis-1883	50	37	calcium	calcium	NOUN
fcis-1883	50	38	overload	overload	NOUN
fcis-1883	50	39	of	of	ADP
fcis-1883	50	40	ischemic	ischemic	ADJ
fcis-1883	50	41	cells	cell	NOUN
fcis-1883	50	42	was	be	AUX
fcis-1883	50	43	reduced	reduce	VERB
fcis-1883	50	44	.	.	PUNCT
fcis-1883	51	1	therefore	therefore	ADV
fcis-1883	51	2	,	,	PUNCT
fcis-1883	51	3	we	we	PRON
fcis-1883	51	4	can	can	AUX
fcis-1883	51	5	more	more	ADV
fcis-1883	51	6	clearly	clearly	ADV
fcis-1883	51	7	understand	understand	VERB
fcis-1883	51	8	the	the	DET
fcis-1883	51	9	existence	existence	NOUN
fcis-1883	51	10	of	of	ADP
fcis-1883	51	11	calcium	calcium	NOUN
fcis-1883	51	12	triggered	trigger	VERB
fcis-1883	51	13	calcium	calcium	NOUN
fcis-1883	51	14	release	release	NOUN
fcis-1883	51	15	(	(	PUNCT
fcis-1883	51	16	cicr	cicr	NOUN
fcis-1883	51	17	)	)	PUNCT
fcis-1883	51	18	mechanism	mechanism	NOUN
fcis-1883	51	19	caused	cause	VERB
fcis-1883	51	20	by	by	ADP
fcis-1883	51	21	l	l	NOUN
fcis-1883	51	22	-	-	PUNCT
fcis-1883	51	23	type	type	NOUN
fcis-1883	51	24	calcium	calcium	NOUN
fcis-1883	51	25	channel	channel	NOUN
fcis-1883	51	26	.	.	PUNCT
fcis-1883	52	1	2.5	2.5	NUM
fcis-1883	52	2	.	.	PUNCT
fcis-1883	53	1	ryanodine	ryanodine	PROPN
fcis-1883	53	2	receptor	receptor	NOUN
fcis-1883	53	3	(	(	PUNCT
fcis-1883	53	4	ryr	ryr	NOUN
fcis-1883	53	5	)	)	PUNCT
fcis-1883	53	6	renotin	renotin	NOUN
fcis-1883	53	7	receptor	receptor	NOUN
fcis-1883	53	8	is	be	AUX
fcis-1883	53	9	a	a	DET
fcis-1883	53	10	calcium	calcium	NOUN
fcis-1883	53	11	releasing	releasing	NOUN
fcis-1883	53	12	channel	channel	NOUN
fcis-1883	53	13	located	locate	VERB
fcis-1883	53	14	in	in	ADP
fcis-1883	53	15	the	the	DET
fcis-1883	53	16	endoplasmic	endoplasmic	ADJ
fcis-1883	53	17	reticulum	reticulum	NOUN
fcis-1883	53	18	/	/	SYM
fcis-1883	53	19	sarcoplasmic	sarcoplasmic	NOUN
fcis-1883	53	20	reticulum	reticulum	NOUN
fcis-1883	53	21	(	(	PUNCT
fcis-1883	53	22	er	er	INTJ
fcis-1883	53	23	/	/	SYM
fcis-1883	53	24	sr	sr	PROPN
fcis-1883	53	25	)	)	PUNCT
fcis-1883	53	26	.	.	PUNCT
fcis-1883	54	1	it	it	PRON
fcis-1883	54	2	can	can	AUX
fcis-1883	54	3	rapidly	rapidly	ADV
fcis-1883	54	4	release	release	VERB
fcis-1883	54	5	calcium	calcium	NOUN
fcis-1883	54	6	ions	ion	NOUN
fcis-1883	54	7	from	from	ADP
fcis-1883	54	8	er	er	INTJ
fcis-1883	54	9	/	/	SYM
fcis-1883	54	10	sr	sr	PROPN
fcis-1883	54	11	,	,	PUNCT
fcis-1883	54	12	and	and	CCONJ
fcis-1883	54	13	is	be	AUX
fcis-1883	54	14	an	an	DET
fcis-1883	54	15	important	important	ADJ
fcis-1883	54	16	link	link	NOUN
fcis-1883	54	17	of	of	ADP
fcis-1883	54	18	cardiac	cardiac	ADJ
fcis-1883	54	19	excitation	excitation	NOUN
fcis-1883	54	20	contraction	contraction	NOUN
fcis-1883	54	21	mechanism	mechanism	NOUN
fcis-1883	54	22	[	[	X
fcis-1883	54	23	13	13	NUM
fcis-1883	54	24	]	]	PUNCT
fcis-1883	54	25	.	.	PUNCT
fcis-1883	55	1	toit	toit	PROPN
fcis-1883	55	2	et	et	PROPN
fcis-1883	55	3	al	al	PROPN
fcis-1883	55	4	.	.	PUNCT
fcis-1883	56	1	[	[	X
fcis-1883	56	2	14	14	NUM
fcis-1883	56	3	]	]	PUNCT
fcis-1883	56	4	verified	verify	VERB
fcis-1883	56	5	whether	whether	SCONJ
fcis-1883	56	6	"	"	PUNCT
fcis-1883	56	7	at	at	ADP
fcis-1883	56	8	the	the	DET
fcis-1883	56	9	beginning	beginning	NOUN
fcis-1883	56	10	of	of	ADP
fcis-1883	56	11	reperfusion	reperfusion	NOUN
fcis-1883	56	12	,	,	PUNCT
fcis-1883	56	13	the	the	DET
fcis-1883	56	14	reduction	reduction	NOUN
fcis-1883	56	15	of	of	ADP
fcis-1883	56	16	calcium	calcium	NOUN
fcis-1883	56	17	flow	flow	NOUN
fcis-1883	56	18	through	through	ADP
fcis-1883	56	19	the	the	DET
fcis-1883	56	20	sarcolemma	sarcolemma	NOUN
fcis-1883	56	21	or	or	CCONJ
fcis-1883	56	22	sarcoplasmic	sarcoplasmic	ADJ
fcis-1883	56	23	reticulum	reticulum	NOUN
fcis-1883	56	24	can	can	AUX
fcis-1883	56	25	reduce	reduce	VERB
fcis-1883	56	26	the	the	DET
fcis-1883	56	27	subsequent	subsequent	ADJ
fcis-1883	56	28	mechanical	mechanical	ADJ
fcis-1883	56	29	stunning	stunning	ADJ
fcis-1883	56	30	"	"	PUNCT
fcis-1883	56	31	.	.	PUNCT
fcis-1883	57	1	the	the	DET
fcis-1883	57	2	isolated	isolated	ADJ
fcis-1883	57	3	active	active	ADJ
fcis-1883	57	4	rat	rat	NOUN
fcis-1883	57	5	hearts	heart	NOUN
fcis-1883	57	6	were	be	AUX
fcis-1883	57	7	subjected	subject	VERB
fcis-1883	57	8	to	to	ADP
fcis-1883	57	9	ischemia	ischemia	NOUN
fcis-1883	57	10	-	-	PUNCT
fcis-1883	57	11	reperfusion	reperfusion	NOUN
fcis-1883	57	12	treatment	treatment	NOUN
fcis-1883	57	13	,	,	PUNCT
fcis-1883	57	14	and	and	CCONJ
fcis-1883	57	15	the	the	DET
fcis-1883	57	16	cardiac	cardiac	ADJ
fcis-1883	57	17	output	output	NOUN
fcis-1883	57	18	of	of	ADP
fcis-1883	57	19	the	the	DET
fcis-1883	57	20	experimental	experimental	ADJ
fcis-1883	57	21	group	group	NOUN
fcis-1883	57	22	added	add	VERB
fcis-1883	57	23	with	with	ADP
fcis-1883	57	24	ryr	ryr	NOUN
fcis-1883	57	25	(	(	PUNCT
fcis-1883	57	26	a	a	DET
fcis-1883	57	27	pharmacological	pharmacological	ADJ
fcis-1883	57	28	inhibitor	inhibitor	NOUN
fcis-1883	57	29	of	of	ADP
fcis-1883	57	30	ryr	ryr	NOUN
fcis-1883	57	31	)	)	PUNCT
fcis-1883	57	32	was	be	AUX
fcis-1883	57	33	significantly	significantly	ADV
fcis-1883	57	34	higher	high	ADJ
fcis-1883	57	35	than	than	ADP
fcis-1883	57	36	that	that	PRON
fcis-1883	57	37	of	of	ADP
fcis-1883	57	38	the	the	DET
fcis-1883	57	39	control	control	NOUN
fcis-1883	57	40	group	group	NOUN
fcis-1883	57	41	without	without	ADP
fcis-1883	57	42	drug	drug	NOUN
fcis-1883	57	43	inhibition	inhibition	NOUN
fcis-1883	57	44	.	.	PUNCT
fcis-1883	58	1	it	it	PRON
fcis-1883	58	2	shows	show	VERB
fcis-1883	58	3	that	that	SCONJ
fcis-1883	58	4	during	during	ADP
fcis-1883	58	5	the	the	DET
fcis-1883	58	6	period	period	NOUN
fcis-1883	58	7	of	of	ADP
fcis-1883	58	8	ischemia	ischemia	NOUN
fcis-1883	58	9	-	-	PUNCT
fcis-1883	58	10	reperfusion	reperfusion	NOUN
fcis-1883	58	11	,	,	PUNCT
fcis-1883	58	12	pharmacological	pharmacological	ADJ
fcis-1883	58	13	inhibitors	inhibitor	NOUN
fcis-1883	58	14	can	can	AUX
fcis-1883	58	15	inhibit	inhibit	VERB
fcis-1883	58	16	ryr	ryr	NOUN
fcis-1883	58	17	,	,	PUNCT
fcis-1883	58	18	reduce	reduce	VERB
fcis-1883	58	19	the	the	DET
fcis-1883	58	20	calcium	calcium	NOUN
fcis-1883	58	21	release	release	NOUN
fcis-1883	58	22	of	of	ADP
fcis-1883	58	23	sarcoplasmic	sarcoplasmic	ADJ
fcis-1883	58	24	reticulum	reticulum	NOUN
fcis-1883	58	25	,	,	PUNCT
fcis-1883	58	26	reduce	reduce	VERB
fcis-1883	58	27	the	the	DET
fcis-1883	58	28	intracellular	intracellular	ADJ
fcis-1883	58	29	ca2	ca2	PROPN
fcis-1883	58	30	+	+	NOUN
fcis-1883	58	31	overload	overload	NOUN
fcis-1883	58	32	,	,	PUNCT
fcis-1883	58	33	and	and	CCONJ
fcis-1883	58	34	significantly	significantly	ADV
fcis-1883	58	35	facilitate	facilitate	VERB
fcis-1883	58	36	the	the	DET
fcis-1883	58	37	recovery	recovery	NOUN
fcis-1883	58	38	of	of	ADP
fcis-1883	58	39	contraction	contraction	NOUN
fcis-1883	58	40	.	.	PUNCT
fcis-1883	59	1	2.6	2.6	NUM
fcis-1883	59	2	.	.	PUNCT
fcis-1883	60	1	ca2+/calmodulin	ca2+/calmodulin	PROPN
fcis-1883	60	2	dependent	dependent	ADJ
fcis-1883	60	3	protein	protein	NOUN
fcis-1883	60	4	kinase	kinase	NOUN
fcis-1883	60	5	ii(camkii	ii(camkii	PROPN
fcis-1883	60	6	)	)	PUNCT
fcis-1883	61	1	camkii	camkii	PROPN
fcis-1883	61	2	is	be	AUX
fcis-1883	61	3	a	a	DET
fcis-1883	61	4	key	key	ADJ
fcis-1883	61	5	mediator	mediator	NOUN
fcis-1883	61	6	,	,	PUNCT
fcis-1883	61	7	which	which	PRON
fcis-1883	61	8	regulates	regulate	VERB
fcis-1883	61	9	excitation	excitation	NOUN
fcis-1883	61	10	contraction	contraction	NOUN
fcis-1883	61	11	coupling	coupling	NOUN
fcis-1883	61	12	of	of	ADP
fcis-1883	61	13	myocardial	myocardial	ADJ
fcis-1883	61	14	cells	cell	NOUN
fcis-1883	61	15	through	through	ADP
fcis-1883	61	16	phosphorylation	phosphorylation	NOUN
fcis-1883	61	17	of	of	ADP
fcis-1883	61	18	ryr2	ryr2	PROPN
fcis-1883	61	19	,	,	PUNCT
fcis-1883	61	20	plb	plb	PROPN
fcis-1883	61	21	/	/	SYM
fcis-1883	61	22	serca2a	serca2a	PROPN
fcis-1883	61	23	and	and	CCONJ
fcis-1883	61	24	ltcc	ltcc	ADP
fcis-1883	61	25	[	[	X
fcis-1883	61	26	15	15	NUM
fcis-1883	61	27	]	]	PUNCT
fcis-1883	61	28	.	.	PUNCT
fcis-1883	62	1	of	of	ADP
fcis-1883	62	2	course	course	NOUN
fcis-1883	62	3	,	,	PUNCT
fcis-1883	62	4	its	its	PRON
fcis-1883	62	5	effect	effect	NOUN
fcis-1883	62	6	on	on	ADP
fcis-1883	62	7	calcium	calcium	NOUN
fcis-1883	62	8	transport	transport	NOUN
fcis-1883	62	9	is	be	AUX
fcis-1883	62	10	mainly	mainly	ADV
fcis-1883	62	11	through	through	ADP
fcis-1883	62	12	the	the	DET
fcis-1883	62	13	activation	activation	NOUN
fcis-1883	62	14	of	of	ADP
fcis-1883	62	15	voltage	voltage	NOUN
fcis-1883	62	16	gated	gate	VERB
fcis-1883	62	17	calcium	calcium	NOUN
fcis-1883	62	18	channels	channel	NOUN
fcis-1883	62	19	to	to	PART
fcis-1883	62	20	make	make	VERB
fcis-1883	62	21	calcium	calcium	NOUN
fcis-1883	62	22	ions	ion	NOUN
fcis-1883	62	23	flow	flow	VERB
fcis-1883	62	24	in	in	ADP
fcis-1883	62	25	,	,	PUNCT
fcis-1883	62	26	thus	thus	ADV
fcis-1883	62	27	triggering	trigger	VERB
fcis-1883	62	28	a	a	DET
fcis-1883	62	29	series	series	NOUN
fcis-1883	62	30	of	of	ADP
fcis-1883	62	31	mechanisms	mechanism	NOUN
fcis-1883	62	32	to	to	PART
fcis-1883	62	33	increase	increase	VERB
fcis-1883	62	34	the	the	DET
fcis-1883	62	35	intracellular	intracellular	ADJ
fcis-1883	62	36	calcium	calcium	NOUN
fcis-1883	62	37	concentration	concentration	NOUN
fcis-1883	62	38	.	.	PUNCT
fcis-1883	63	1	at	at	ADP
fcis-1883	63	2	the	the	DET
fcis-1883	63	3	same	same	ADJ
fcis-1883	63	4	time	time	NOUN
fcis-1883	63	5	,	,	PUNCT
fcis-1883	63	6	the	the	DET
fcis-1883	63	7	overexpression	overexpression	NOUN
fcis-1883	63	8	of	of	ADP
fcis-1883	63	9	calmodulin	calmodulin	NOUN
fcis-1883	63	10	dependent	dependent	ADJ
fcis-1883	63	11	protein	protein	NOUN
fcis-1883	63	12	kinase	kinase	PROPN
fcis-1883	63	13	ii	ii	PROPN
fcis-1883	63	14	will	will	AUX
fcis-1883	63	15	also	also	ADV
fcis-1883	63	16	prolong	prolong	VERB
fcis-1883	63	17	the	the	DET
fcis-1883	63	18	calcium	calcium	NOUN
fcis-1883	63	19	current	current	ADJ
fcis-1883	63	20	time	time	NOUN
fcis-1883	63	21	and	and	CCONJ
fcis-1883	63	22	increase	increase	VERB
fcis-1883	63	23	its	its	PRON
fcis-1883	63	24	amplitude	amplitude	NOUN
fcis-1883	63	25	,	,	PUNCT
fcis-1883	63	26	thus	thus	ADV
fcis-1883	63	27	increasing	increase	VERB
fcis-1883	63	28	calcium	calcium	NOUN
fcis-1883	63	29	overload	overload	NOUN
fcis-1883	63	30	[	[	X
fcis-1883	63	31	16	16	NUM
fcis-1883	63	32	]	]	PUNCT
fcis-1883	63	33	.	.	PUNCT
fcis-1883	64	1	fig.1	fig.1	ADJ
fcis-1883	64	2	flow	flow	NOUN
fcis-1883	64	3	chart	chart	NOUN
fcis-1883	64	4	of	of	ADP
fcis-1883	64	5	calcium	calcium	NOUN
fcis-1883	64	6	overload	overload	NOUN
fcis-1883	64	7	mechanism	mechanism	NOUN
fcis-1883	64	8	2.7	2.7	NUM
fcis-1883	64	9	.	.	PUNCT
fcis-1883	65	1	generalization	generalization	NOUN
fcis-1883	65	2	the	the	DET
fcis-1883	65	3	oxygen	oxygen	NOUN
fcis-1883	65	4	supply	supply	NOUN
fcis-1883	65	5	of	of	ADP
fcis-1883	65	6	cells	cell	NOUN
fcis-1883	65	7	in	in	ADP
fcis-1883	65	8	the	the	DET
fcis-1883	65	9	myocardial	myocardial	ADJ
fcis-1883	65	10	ischemic	ischemic	ADJ
fcis-1883	65	11	area	area	NOUN
fcis-1883	65	12	is	be	AUX
fcis-1883	65	13	insufficient	insufficient	ADJ
fcis-1883	65	14	,	,	PUNCT
fcis-1883	65	15	and	and	CCONJ
fcis-1883	65	16	atp	atp	PROPN
fcis-1883	65	17	can	can	AUX
fcis-1883	65	18	only	only	ADV
fcis-1883	65	19	be	be	AUX
fcis-1883	65	20	produced	produce	VERB
fcis-1883	65	21	by	by	ADP
fcis-1883	65	22	anaerobic	anaerobic	ADJ
fcis-1883	65	23	glycolysis	glycolysis	NOUN
fcis-1883	65	24	.	.	PUNCT
fcis-1883	66	1	anaerobic	anaerobic	NOUN
fcis-1883	66	2	glycolysis	glycolysis	NOUN
fcis-1883	66	3	will	will	AUX
fcis-1883	66	4	produce	produce	VERB
fcis-1883	66	5	a	a	DET
fcis-1883	66	6	large	large	ADJ
fcis-1883	66	7	amount	amount	NOUN
fcis-1883	66	8	76	76	NUM
fcis-1883	66	9	of	of	ADP
fcis-1883	66	10	lactic	lactic	ADJ
fcis-1883	66	11	acid	acid	NOUN
fcis-1883	66	12	,	,	PUNCT
fcis-1883	66	13	h+	h+	PUNCT
fcis-1883	66	14	and	and	CCONJ
fcis-1883	66	15	nadh+	nadh+	ADV
fcis-1883	66	16	.	.	PUNCT
fcis-1883	67	1	when	when	SCONJ
fcis-1883	67	2	they	they	PRON
fcis-1883	67	3	accumulate	accumulate	VERB
fcis-1883	67	4	in	in	ADP
fcis-1883	67	5	the	the	DET
fcis-1883	67	6	cells	cell	NOUN
fcis-1883	67	7	to	to	ADP
fcis-1883	67	8	a	a	DET
fcis-1883	67	9	certain	certain	ADJ
fcis-1883	67	10	extent	extent	NOUN
fcis-1883	67	11	,	,	PUNCT
fcis-1883	67	12	the	the	DET
fcis-1883	67	13	acid	acid	NOUN
fcis-1883	67	14	-	-	PUNCT
fcis-1883	67	15	base	base	NOUN
fcis-1883	67	16	balance	balance	NOUN
fcis-1883	67	17	of	of	ADP
fcis-1883	67	18	the	the	DET
fcis-1883	67	19	cytoplasm	cytoplasm	NOUN
fcis-1883	67	20	will	will	AUX
fcis-1883	67	21	be	be	AUX
fcis-1883	67	22	broken	break	VERB
fcis-1883	67	23	,	,	PUNCT
fcis-1883	67	24	and	and	CCONJ
fcis-1883	67	25	the	the	DET
fcis-1883	67	26	body	body	NOUN
fcis-1883	67	27	will	will	AUX
fcis-1883	67	28	exchange	exchange	VERB
fcis-1883	67	29	hydrogen	hydrogen	NOUN
fcis-1883	67	30	ions	ion	NOUN
fcis-1883	67	31	and	and	CCONJ
fcis-1883	67	32	sodium	sodium	NOUN
fcis-1883	67	33	ions	ion	NOUN
fcis-1883	67	34	in	in	ADP
fcis-1883	67	35	the	the	DET
fcis-1883	67	36	cells	cell	NOUN
fcis-1883	67	37	by	by	ADP
fcis-1883	67	38	activating	activate	VERB
fcis-1883	67	39	nhe	nhe	NOUN
fcis-1883	67	40	,	,	PUNCT
fcis-1883	67	41	increasing	increase	VERB
fcis-1883	67	42	the	the	DET
fcis-1883	67	43	ph	ph	ADJ
fcis-1883	67	44	value	value	NOUN
fcis-1883	67	45	in	in	ADP
fcis-1883	67	46	the	the	DET
fcis-1883	67	47	cells	cell	NOUN
fcis-1883	67	48	,	,	PUNCT
fcis-1883	67	49	and	and	CCONJ
fcis-1883	67	50	rebuilding	rebuild	VERB
fcis-1883	67	51	the	the	DET
fcis-1883	67	52	acidbase	acidbase	ADJ
fcis-1883	67	53	balance	balance	NOUN
fcis-1883	67	54	.	.	PUNCT
fcis-1883	68	1	at	at	ADP
fcis-1883	68	2	the	the	DET
fcis-1883	68	3	same	same	ADJ
fcis-1883	68	4	time	time	NOUN
fcis-1883	68	5	,	,	PUNCT
fcis-1883	68	6	the	the	DET
fcis-1883	68	7	influx	influx	NOUN
fcis-1883	68	8	of	of	ADP
fcis-1883	68	9	sodium	sodium	NOUN
fcis-1883	68	10	ions	ion	NOUN
fcis-1883	68	11	activates	activate	VERB
fcis-1883	68	12	the	the	DET
fcis-1883	68	13	pathological	pathological	ADJ
fcis-1883	68	14	state	state	NOUN
fcis-1883	68	15	of	of	ADP
fcis-1883	68	16	ncx	ncx	PROPN
fcis-1883	68	17	,	,	PUNCT
fcis-1883	68	18	in	in	ADP
fcis-1883	68	19	which	which	PRON
fcis-1883	68	20	ncx	ncx	ADP
fcis-1883	68	21	exchanges	exchange	NOUN
fcis-1883	68	22	sodium	sodium	NOUN
fcis-1883	68	23	ions	ion	NOUN
fcis-1883	68	24	inside	inside	ADP
fcis-1883	68	25	cells	cell	NOUN
fcis-1883	68	26	with	with	ADP
fcis-1883	68	27	calcium	calcium	NOUN
fcis-1883	68	28	ions	ion	NOUN
fcis-1883	68	29	outside	outside	ADP
fcis-1883	68	30	cells	cell	NOUN
fcis-1883	68	31	.	.	PUNCT
fcis-1883	69	1	during	during	ADP
fcis-1883	69	2	blood	blood	NOUN
fcis-1883	69	3	flow	flow	NOUN
fcis-1883	69	4	reperfusion	reperfusion	NOUN
fcis-1883	69	5	,	,	PUNCT
fcis-1883	69	6	the	the	DET
fcis-1883	69	7	hydrogen	hydrogen	NOUN
fcis-1883	69	8	ions	ion	NOUN
fcis-1883	69	9	accumulated	accumulate	VERB
fcis-1883	69	10	outside	outside	ADP
fcis-1883	69	11	the	the	DET
fcis-1883	69	12	cells	cell	NOUN
fcis-1883	69	13	in	in	ADP
fcis-1883	69	14	the	the	DET
fcis-1883	69	15	ischemic	ischemic	ADJ
fcis-1883	69	16	period	period	NOUN
fcis-1883	69	17	are	be	AUX
fcis-1883	69	18	taken	take	VERB
fcis-1883	69	19	away	away	ADV
fcis-1883	69	20	,	,	PUNCT
fcis-1883	69	21	thus	thus	ADV
fcis-1883	69	22	increasing	increase	VERB
fcis-1883	69	23	the	the	DET
fcis-1883	69	24	gradient	gradient	ADJ
fcis-1883	69	25	difference	difference	NOUN
fcis-1883	69	26	of	of	ADP
fcis-1883	69	27	hydrogen	hydrogen	NOUN
fcis-1883	69	28	ion	ion	NOUN
fcis-1883	69	29	concentration	concentration	NOUN
fcis-1883	69	30	inside	inside	ADP
fcis-1883	69	31	and	and	CCONJ
fcis-1883	69	32	outside	outside	ADP
fcis-1883	69	33	the	the	DET
fcis-1883	69	34	cell	cell	NOUN
fcis-1883	69	35	membrane	membrane	NOUN
fcis-1883	69	36	,	,	PUNCT
fcis-1883	69	37	which	which	PRON
fcis-1883	69	38	will	will	AUX
fcis-1883	69	39	further	far	ADV
fcis-1883	69	40	stimulate	stimulate	VERB
fcis-1883	69	41	the	the	DET
fcis-1883	69	42	activity	activity	NOUN
fcis-1883	69	43	of	of	ADP
fcis-1883	69	44	sodium	sodium	NOUN
fcis-1883	69	45	hydrogen	hydrogen	NOUN
fcis-1883	69	46	exchanger	exchanger	NOUN
fcis-1883	69	47	and	and	CCONJ
fcis-1883	69	48	indirectly	indirectly	ADV
fcis-1883	69	49	promote	promote	VERB
fcis-1883	69	50	the	the	DET
fcis-1883	69	51	further	further	ADJ
fcis-1883	69	52	increase	increase	NOUN
fcis-1883	69	53	of	of	ADP
fcis-1883	69	54	calcium	calcium	NOUN
fcis-1883	69	55	ion	ion	NOUN
fcis-1883	69	56	concentration	concentration	NOUN
fcis-1883	69	57	in	in	ADP
fcis-1883	69	58	the	the	DET
fcis-1883	69	59	cytoplasm	cytoplasm	NOUN
fcis-1883	69	60	.	.	PUNCT
fcis-1883	70	1	in	in	ADP
fcis-1883	70	2	addition	addition	NOUN
fcis-1883	70	3	,	,	PUNCT
fcis-1883	70	4	the	the	DET
fcis-1883	70	5	ability	ability	NOUN
fcis-1883	70	6	of	of	ADP
fcis-1883	70	7	calcium	calcium	NOUN
fcis-1883	70	8	pump	pump	NOUN
fcis-1883	70	9	of	of	ADP
fcis-1883	70	10	endoplasmic	endoplasmic	ADJ
fcis-1883	70	11	reticulum	reticulum	NOUN
fcis-1883	70	12	/	/	SYM
fcis-1883	70	13	sarcoplasmic	sarcoplasmic	NOUN
fcis-1883	70	14	reticulum	reticulum	NOUN
fcis-1883	70	15	to	to	PART
fcis-1883	70	16	process	process	VERB
fcis-1883	70	17	ca2	ca2	PROPN
fcis-1883	70	18	+	+	PROPN
fcis-1883	70	19	was	be	AUX
fcis-1883	70	20	impaired	impair	VERB
fcis-1883	70	21	by	by	ADP
fcis-1883	70	22	ischemia	ischemia	NOUN
fcis-1883	70	23	/	/	SYM
fcis-1883	70	24	reperfusion	reperfusion	NOUN
fcis-1883	70	25	,	,	PUNCT
fcis-1883	70	26	and	and	CCONJ
fcis-1883	70	27	the	the	DET
fcis-1883	70	28	ability	ability	NOUN
fcis-1883	70	29	to	to	PART
fcis-1883	70	30	reuptake	reuptake	VERB
fcis-1883	70	31	ca2	ca2	PROPN
fcis-1883	70	32	+	+	PROPN
fcis-1883	70	33	from	from	ADP
fcis-1883	70	34	cytoplasm	cytoplasm	NOUN
fcis-1883	70	35	was	be	AUX
fcis-1883	70	36	severely	severely	ADV
fcis-1883	70	37	reduced	reduce	VERB
fcis-1883	70	38	.	.	PUNCT
fcis-1883	71	1	at	at	ADP
fcis-1883	71	2	the	the	DET
fcis-1883	71	3	same	same	ADJ
fcis-1883	71	4	time	time	NOUN
fcis-1883	71	5	,	,	PUNCT
fcis-1883	71	6	l	l	NOUN
fcis-1883	71	7	-	-	PUNCT
fcis-1883	71	8	type	type	NOUN
fcis-1883	71	9	calcium	calcium	NOUN
fcis-1883	71	10	channel	channel	NOUN
fcis-1883	71	11	opens	open	VERB
fcis-1883	71	12	,	,	PUNCT
fcis-1883	71	13	a	a	DET
fcis-1883	71	14	large	large	ADJ
fcis-1883	71	15	number	number	NOUN
fcis-1883	71	16	of	of	ADP
fcis-1883	71	17	calcium	calcium	NOUN
fcis-1883	71	18	ions	ion	NOUN
fcis-1883	71	19	enter	enter	VERB
fcis-1883	71	20	the	the	DET
fcis-1883	71	21	cell	cell	NOUN
fcis-1883	71	22	and	and	CCONJ
fcis-1883	71	23	activate	activate	VERB
fcis-1883	71	24	the	the	DET
fcis-1883	71	25	calcium	calcium	NOUN
fcis-1883	71	26	triggered	trigger	VERB
fcis-1883	71	27	calcium	calcium	NOUN
fcis-1883	71	28	release	release	NOUN
fcis-1883	71	29	mechanism	mechanism	NOUN
fcis-1883	71	30	,	,	PUNCT
fcis-1883	71	31	causing	cause	VERB
fcis-1883	71	32	the	the	DET
fcis-1883	71	33	rapid	rapid	ADJ
fcis-1883	71	34	release	release	NOUN
fcis-1883	71	35	of	of	ADP
fcis-1883	71	36	calcium	calcium	NOUN
fcis-1883	71	37	ions	ion	NOUN
fcis-1883	71	38	from	from	ADP
fcis-1883	71	39	er	er	INTJ
fcis-1883	71	40	/	/	SYM
fcis-1883	71	41	sr	sr	PROPN
fcis-1883	71	42	by	by	ADP
fcis-1883	71	43	the	the	DET
fcis-1883	71	44	ranodine	ranodine	ADJ
fcis-1883	71	45	receptor	receptor	NOUN
fcis-1883	71	46	.	.	PUNCT
fcis-1883	72	1	these	these	DET
fcis-1883	72	2	two	two	NUM
fcis-1883	72	3	mechanisms	mechanism	NOUN
fcis-1883	72	4	together	together	ADV
fcis-1883	72	5	lead	lead	VERB
fcis-1883	72	6	to	to	ADP
fcis-1883	72	7	a	a	DET
fcis-1883	72	8	further	far	ADV
fcis-1883	72	9	lethal	lethal	ADJ
fcis-1883	72	10	increase	increase	NOUN
fcis-1883	72	11	in	in	ADP
fcis-1883	72	12	the	the	DET
fcis-1883	72	13	level	level	NOUN
fcis-1883	72	14	of	of	ADP
fcis-1883	72	15	cytoplasmic	cytoplasmic	ADJ
fcis-1883	72	16	ca2	ca2	PROPN
fcis-1883	72	17	+	+	X
fcis-1883	72	18	in	in	ADP
fcis-1883	72	19	myocardial	myocardial	ADJ
fcis-1883	72	20	cells	cell	NOUN
fcis-1883	72	21	[	[	X
fcis-1883	72	22	17	17	NUM
fcis-1883	72	23	]	]	PUNCT
fcis-1883	72	24	.	.	PUNCT
fcis-1883	73	1	to	to	PART
fcis-1883	73	2	sum	sum	VERB
fcis-1883	73	3	up	up	ADP
fcis-1883	73	4	,	,	PUNCT
fcis-1883	73	5	cells	cell	NOUN
fcis-1883	73	6	in	in	ADP
fcis-1883	73	7	the	the	DET
fcis-1883	73	8	ischemic	ischemic	ADJ
fcis-1883	73	9	region	region	NOUN
fcis-1883	73	10	have	have	VERB
fcis-1883	73	11	multiple	multiple	ADJ
fcis-1883	73	12	mechanisms	mechanism	NOUN
fcis-1883	73	13	working	work	VERB
fcis-1883	73	14	together	together	ADV
fcis-1883	73	15	to	to	PART
fcis-1883	73	16	promote	promote	VERB
fcis-1883	73	17	a	a	DET
fcis-1883	73	18	significant	significant	ADJ
fcis-1883	73	19	increase	increase	NOUN
fcis-1883	73	20	in	in	ADP
fcis-1883	73	21	intracellular	intracellular	ADJ
fcis-1883	73	22	calcium	calcium	NOUN
fcis-1883	73	23	concentration	concentration	NOUN
fcis-1883	73	24	,	,	PUNCT
fcis-1883	73	25	which	which	PRON
fcis-1883	73	26	in	in	ADP
fcis-1883	73	27	turn	turn	NOUN
fcis-1883	73	28	activates	activate	VERB
fcis-1883	73	29	a	a	DET
fcis-1883	73	30	variety	variety	NOUN
fcis-1883	73	31	of	of	ADP
fcis-1883	73	32	processes	process	NOUN
fcis-1883	73	33	,	,	PUNCT
fcis-1883	73	34	which	which	PRON
fcis-1883	73	35	lead	lead	VERB
fcis-1883	73	36	to	to	ADP
fcis-1883	73	37	cell	cell	NOUN
fcis-1883	73	38	death	death	NOUN
fcis-1883	73	39	after	after	ADP
fcis-1883	73	40	ischemia	ischemia	NOUN
fcis-1883	73	41	-	-	PUNCT
fcis-1883	73	42	reperfusion	reperfusion	NOUN
fcis-1883	73	43	.	.	PUNCT
fcis-1883	74	1	next	next	ADV
fcis-1883	74	2	,	,	PUNCT
fcis-1883	74	3	the	the	DET
fcis-1883	74	4	second	second	ADJ
fcis-1883	74	5	part	part	NOUN
fcis-1883	74	6	of	of	ADP
fcis-1883	74	7	this	this	DET
fcis-1883	74	8	paper	paper	NOUN
fcis-1883	74	9	will	will	AUX
fcis-1883	74	10	discuss	discuss	VERB
fcis-1883	74	11	these	these	DET
fcis-1883	74	12	processes	process	NOUN
fcis-1883	74	13	.	.	PUNCT
fcis-1883	75	1	3	3	X
fcis-1883	75	2	.	.	X
fcis-1883	75	3	the	the	DET
fcis-1883	75	4	role	role	NOUN
fcis-1883	75	5	of	of	ADP
fcis-1883	75	6	calcium	calcium	NOUN
fcis-1883	75	7	overload	overload	NOUN
fcis-1883	75	8	in	in	ADP
fcis-1883	75	9	miri	miri	PROPN
fcis-1883	75	10	3.1	3.1	NUM
fcis-1883	75	11	.	.	PUNCT
fcis-1883	76	1	mitochondrial	mitochondrial	ADJ
fcis-1883	76	2	permeability	permeability	NOUN
fcis-1883	76	3	transition	transition	NOUN
fcis-1883	76	4	(	(	PUNCT
fcis-1883	76	5	mpt	mpt	NOUN
fcis-1883	76	6	)	)	PUNCT
fcis-1883	76	7	mitochondrial	mitochondrial	ADJ
fcis-1883	76	8	injury	injury	NOUN
fcis-1883	76	9	is	be	AUX
fcis-1883	76	10	considered	consider	VERB
fcis-1883	76	11	as	as	ADP
fcis-1883	76	12	a	a	DET
fcis-1883	76	13	sign	sign	NOUN
fcis-1883	76	14	of	of	ADP
fcis-1883	76	15	the	the	DET
fcis-1883	76	16	change	change	NOUN
fcis-1883	76	17	of	of	ADP
fcis-1883	76	18	myocardial	myocardial	ADJ
fcis-1883	76	19	cells	cell	NOUN
fcis-1883	76	20	from	from	ADP
fcis-1883	76	21	reversible	reversible	ADJ
fcis-1883	76	22	injury	injury	NOUN
fcis-1883	76	23	to	to	ADP
fcis-1883	76	24	irreversible	irreversible	ADJ
fcis-1883	76	25	injury	injury	NOUN
fcis-1883	76	26	[	[	X
fcis-1883	76	27	18	18	NUM
fcis-1883	76	28	]	]	PUNCT
fcis-1883	76	29	.	.	PUNCT
fcis-1883	77	1	after	after	SCONJ
fcis-1883	77	2	the	the	DET
fcis-1883	77	3	ischemic	ischemic	ADJ
fcis-1883	77	4	myocardium	myocardium	NOUN
fcis-1883	77	5	was	be	AUX
fcis-1883	77	6	reperfused	reperfuse	VERB
fcis-1883	77	7	by	by	ADP
fcis-1883	77	8	blood	blood	NOUN
fcis-1883	77	9	flow	flow	NOUN
fcis-1883	77	10	,	,	PUNCT
fcis-1883	77	11	the	the	DET
fcis-1883	77	12	cytoplasmic	cytoplasmic	ADJ
fcis-1883	77	13	calcium	calcium	NOUN
fcis-1883	77	14	concentration	concentration	NOUN
fcis-1883	77	15	of	of	ADP
fcis-1883	77	16	ischemic	ischemic	ADJ
fcis-1883	77	17	cells	cell	NOUN
fcis-1883	77	18	fluctuated	fluctuate	VERB
fcis-1883	77	19	strongly	strongly	ADV
fcis-1883	77	20	.	.	PUNCT
fcis-1883	78	1	in	in	ADP
fcis-1883	78	2	order	order	NOUN
fcis-1883	78	3	to	to	PART
fcis-1883	78	4	reduce	reduce	VERB
fcis-1883	78	5	the	the	DET
fcis-1883	78	6	concentration	concentration	NOUN
fcis-1883	78	7	of	of	ADP
fcis-1883	78	8	calcium	calcium	NOUN
fcis-1883	78	9	ions	ion	NOUN
fcis-1883	78	10	in	in	ADP
fcis-1883	78	11	the	the	DET
fcis-1883	78	12	cytoplasm	cytoplasm	NOUN
fcis-1883	78	13	,	,	PUNCT
fcis-1883	78	14	the	the	DET
fcis-1883	78	15	body	body	NOUN
fcis-1883	78	16	will	will	AUX
fcis-1883	78	17	use	use	VERB
fcis-1883	78	18	the	the	DET
fcis-1883	78	19	potential	potential	ADJ
fcis-1883	78	20	difference	difference	NOUN
fcis-1883	78	21	between	between	ADP
fcis-1883	78	22	the	the	DET
fcis-1883	78	23	two	two	NUM
fcis-1883	78	24	sides	side	NOUN
fcis-1883	78	25	of	of	ADP
fcis-1883	78	26	the	the	DET
fcis-1883	78	27	mitochondrial	mitochondrial	ADJ
fcis-1883	78	28	membrane	membrane	NOUN
fcis-1883	78	29	caused	cause	VERB
fcis-1883	78	30	by	by	ADP
fcis-1883	78	31	ischemia	ischemia	NOUN
fcis-1883	78	32	and	and	CCONJ
fcis-1883	78	33	reperfusion	reperfusion	NOUN
fcis-1883	78	34	to	to	AUX
fcis-1883	78	35	transport	transport	VERB
fcis-1883	78	36	calcium	calcium	NOUN
fcis-1883	78	37	ions	ion	NOUN
fcis-1883	78	38	in	in	ADP
fcis-1883	78	39	the	the	DET
fcis-1883	78	40	cytoplasm	cytoplasm	NOUN
fcis-1883	78	41	to	to	ADP
fcis-1883	78	42	the	the	DET
fcis-1883	78	43	mitochondrial	mitochondrial	ADJ
fcis-1883	78	44	matrix	matrix	NOUN
fcis-1883	78	45	by	by	ADP
fcis-1883	78	46	using	use	VERB
fcis-1883	78	47	the	the	DET
fcis-1883	78	48	one	one	NUM
fcis-1883	78	49	-	-	PUNCT
fcis-1883	78	50	way	way	NOUN
fcis-1883	78	51	calcium	calcium	NOUN
fcis-1883	78	52	transporter	transporter	NOUN
fcis-1883	78	53	protein	protein	NOUN
fcis-1883	78	54	on	on	ADP
fcis-1883	78	55	the	the	DET
fcis-1883	78	56	mitochondrial	mitochondrial	ADJ
fcis-1883	78	57	membrane	membrane	NOUN
fcis-1883	78	58	,	,	PUNCT
fcis-1883	78	59	but	but	CCONJ
fcis-1883	78	60	at	at	ADP
fcis-1883	78	61	the	the	DET
fcis-1883	78	62	same	same	ADJ
fcis-1883	78	63	time	time	NOUN
fcis-1883	78	64	,	,	PUNCT
fcis-1883	78	65	it	it	PRON
fcis-1883	78	66	will	will	AUX
fcis-1883	78	67	also	also	ADV
fcis-1883	78	68	increase	increase	VERB
fcis-1883	78	69	the	the	DET
fcis-1883	78	70	level	level	NOUN
fcis-1883	78	71	of	of	ADP
fcis-1883	78	72	calcium	calcium	NOUN
fcis-1883	78	73	ions	ion	NOUN
fcis-1883	78	74	in	in	ADP
fcis-1883	78	75	the	the	DET
fcis-1883	78	76	mitochondria	mitochondria	NOUN
fcis-1883	78	77	,	,	PUNCT
fcis-1883	78	78	damage	damage	VERB
fcis-1883	78	79	the	the	DET
fcis-1883	78	80	mitochondria	mitochondria	NOUN
fcis-1883	78	81	,	,	PUNCT
fcis-1883	78	82	and	and	CCONJ
fcis-1883	78	83	trigger	trigger	VERB
fcis-1883	78	84	the	the	DET
fcis-1883	78	85	mitochondrial	mitochondrial	ADJ
fcis-1883	78	86	permeability	permeability	NOUN
fcis-1883	78	87	transition	transition	NOUN
fcis-1883	78	88	(	(	PUNCT
fcis-1883	78	89	mpt	mpt	PROPN
fcis-1883	78	90	)	)	PUNCT
fcis-1883	78	91	,	,	PUNCT
fcis-1883	78	92	which	which	PRON
fcis-1883	78	93	is	be	AUX
fcis-1883	78	94	mainly	mainly	ADV
fcis-1883	78	95	manifested	manifest	VERB
fcis-1883	78	96	by	by	ADP
fcis-1883	78	97	the	the	DET
fcis-1883	78	98	opening	opening	NOUN
fcis-1883	78	99	of	of	ADP
fcis-1883	78	100	mptp	mptp	PROPN
fcis-1883	78	101	,	,	PUNCT
fcis-1883	78	102	this	this	PRON
fcis-1883	78	103	is	be	AUX
fcis-1883	78	104	a	a	DET
fcis-1883	78	105	material	material	ADJ
fcis-1883	78	106	channel	channel	NOUN
fcis-1883	78	107	with	with	ADP
fcis-1883	78	108	large	large	ADJ
fcis-1883	78	109	conductance	conductance	NOUN
fcis-1883	78	110	and	and	CCONJ
fcis-1883	78	111	high	high	ADJ
fcis-1883	78	112	flux	flux	NOUN
fcis-1883	78	113	,	,	PUNCT
fcis-1883	78	114	which	which	PRON
fcis-1883	78	115	is	be	AUX
fcis-1883	78	116	mainly	mainly	ADV
fcis-1883	78	117	composed	compose	VERB
fcis-1883	78	118	of	of	ADP
fcis-1883	78	119	adenine	adenine	ADJ
fcis-1883	78	120	nucleotide	nucleotide	NOUN
fcis-1883	78	121	transporter	transporter	NOUN
fcis-1883	78	122	in	in	ADP
fcis-1883	78	123	mitochondrial	mitochondrial	ADJ
fcis-1883	78	124	inner	inner	ADJ
fcis-1883	78	125	membrane	membrane	NOUN
fcis-1883	78	126	,	,	PUNCT
fcis-1883	78	127	cyclophilin	cyclophilin	PROPN
fcis-1883	78	128	d	d	PROPN
fcis-1883	78	129	in	in	ADP
fcis-1883	78	130	matrix	matrix	NOUN
fcis-1883	78	131	and	and	CCONJ
fcis-1883	78	132	blood	blood	NOUN
fcis-1883	78	133	pressure	pressure	NOUN
fcis-1883	78	134	dependent	dependent	ADJ
fcis-1883	78	135	anion	anion	NOUN
fcis-1883	78	136	channel	channel	NOUN
fcis-1883	78	137	(	(	PUNCT
fcis-1883	78	138	vdac	vdac	PROPN
fcis-1883	78	139	)	)	PUNCT
fcis-1883	78	140	.	.	PUNCT
fcis-1883	79	1	when	when	SCONJ
fcis-1883	79	2	opened	open	VERB
fcis-1883	79	3	,	,	PUNCT
fcis-1883	79	4	substances	substance	NOUN
fcis-1883	79	5	with	with	ADP
fcis-1883	79	6	molecular	molecular	ADJ
fcis-1883	79	7	weight	weight	NOUN
fcis-1883	79	8	up	up	ADP
fcis-1883	79	9	to	to	ADP
fcis-1883	79	10	1.5kd	1.5kd	NUM
fcis-1883	79	11	can	can	AUX
fcis-1883	79	12	freely	freely	ADV
fcis-1883	79	13	pass	pass	VERB
fcis-1883	79	14	through	through	ADP
fcis-1883	79	15	[	[	X
fcis-1883	79	16	19	19	NUM
fcis-1883	79	17	]	]	PUNCT
fcis-1883	79	18	.	.	PUNCT
fcis-1883	80	1	with	with	ADP
fcis-1883	80	2	the	the	DET
fcis-1883	80	3	formation	formation	NOUN
fcis-1883	80	4	and	and	CCONJ
fcis-1883	80	5	opening	opening	NOUN
fcis-1883	80	6	of	of	ADP
fcis-1883	80	7	mptp	mptp	PROPN
fcis-1883	80	8	,	,	PUNCT
fcis-1883	80	9	the	the	DET
fcis-1883	80	10	mitochondrial	mitochondrial	ADJ
fcis-1883	80	11	inner	inner	ADJ
fcis-1883	80	12	membrane	membrane	NOUN
fcis-1883	80	13	potential	potential	NOUN
fcis-1883	80	14	began	begin	VERB
fcis-1883	80	15	to	to	PART
fcis-1883	80	16	depolarize	depolarize	VERB
fcis-1883	80	17	and	and	CCONJ
fcis-1883	80	18	the	the	DET
fcis-1883	80	19	mitochondrial	mitochondrial	ADJ
fcis-1883	80	20	matrix	matrix	NOUN
fcis-1883	80	21	began	begin	VERB
fcis-1883	80	22	to	to	PART
fcis-1883	80	23	swell	swell	VERB
fcis-1883	80	24	.	.	PUNCT
fcis-1883	81	1	finally	finally	ADV
fcis-1883	81	2	,	,	PUNCT
fcis-1883	81	3	the	the	DET
fcis-1883	81	4	outer	outer	ADJ
fcis-1883	81	5	membrane	membrane	NOUN
fcis-1883	81	6	of	of	ADP
fcis-1883	81	7	the	the	DET
fcis-1883	81	8	mitochondria	mitochondria	NOUN
fcis-1883	81	9	broke	break	VERB
fcis-1883	81	10	,	,	PUNCT
fcis-1883	81	11	and	and	CCONJ
fcis-1883	81	12	the	the	DET
fcis-1883	81	13	content	content	NOUN
fcis-1883	81	14	flowed	flow	VERB
fcis-1883	81	15	out	out	ADP
fcis-1883	81	16	of	of	ADP
fcis-1883	81	17	the	the	DET
fcis-1883	81	18	cytoplasm	cytoplasm	NOUN
fcis-1883	81	19	.	.	PUNCT
fcis-1883	82	1	the	the	DET
fcis-1883	82	2	proteins	protein	NOUN
fcis-1883	82	3	in	in	ADP
fcis-1883	82	4	the	the	DET
fcis-1883	82	5	content	content	NOUN
fcis-1883	82	6	,	,	PUNCT
fcis-1883	82	7	such	such	ADJ
fcis-1883	82	8	as	as	ADP
fcis-1883	82	9	cytochrome	cytochrome	NOUN
fcis-1883	82	10	c	c	NOUN
fcis-1883	82	11	,	,	PUNCT
fcis-1883	82	12	jointly	jointly	ADV
fcis-1883	82	13	activated	activate	VERB
fcis-1883	82	14	the	the	DET
fcis-1883	82	15	caspase	caspase	NOUN
fcis-1883	82	16	cascade	cascade	NOUN
fcis-1883	82	17	reaction	reaction	NOUN
fcis-1883	82	18	,	,	PUNCT
fcis-1883	82	19	and	and	CCONJ
fcis-1883	82	20	started	start	VERB
fcis-1883	82	21	the	the	DET
fcis-1883	82	22	cell	cell	NOUN
fcis-1883	82	23	lysis	lysis	NOUN
fcis-1883	82	24	process	process	NOUN
fcis-1883	82	25	,	,	PUNCT
fcis-1883	82	26	leading	lead	VERB
fcis-1883	82	27	to	to	ADP
fcis-1883	82	28	cell	cell	NOUN
fcis-1883	82	29	death	death	NOUN
fcis-1883	82	30	.	.	PUNCT
fcis-1883	83	1	baines	baine	NOUN
fcis-1883	83	2	et	et	PROPN
fcis-1883	83	3	al	al	PROPN
fcis-1883	83	4	.	.	PUNCT
fcis-1883	84	1	[	[	X
fcis-1883	84	2	20	20	NUM
fcis-1883	84	3	]	]	PUNCT
fcis-1883	84	4	created	create	VERB
fcis-1883	84	5	mice	mouse	NOUN
fcis-1883	84	6	that	that	PRON
fcis-1883	84	7	cut	cut	VERB
fcis-1883	84	8	off	off	ADP
fcis-1883	84	9	the	the	DET
fcis-1883	84	10	ppif	ppif	ADJ
fcis-1883	84	11	gene	gene	NOUN
fcis-1883	84	12	encoding	encode	VERB
fcis-1883	84	13	cyclophilin	cyclophilin	PROPN
fcis-1883	84	14	d	d	PROPN
fcis-1883	84	15	and	and	CCONJ
fcis-1883	84	16	mice	mouse	NOUN
fcis-1883	84	17	that	that	PRON
fcis-1883	84	18	overexpress	overexpress	VERB
fcis-1883	84	19	cyclophilin	cyclophilin	PROPN
fcis-1883	84	20	d	d	PROPN
fcis-1883	84	21	in	in	ADP
fcis-1883	84	22	the	the	DET
fcis-1883	84	23	heart	heart	NOUN
fcis-1883	84	24	.	.	PUNCT
fcis-1883	85	1	ppif	ppif	ADJ
fcis-1883	85	2	negative	negative	ADJ
fcis-1883	85	3	mice	mouse	NOUN
fcis-1883	85	4	could	could	AUX
fcis-1883	85	5	avoid	avoid	VERB
fcis-1883	85	6	ischemia	ischemia	NOUN
fcis-1883	85	7	/	/	SYM
fcis-1883	85	8	reperfusion	reperfusion	NOUN
fcis-1883	85	9	induced	induce	VERB
fcis-1883	85	10	cell	cell	NOUN
fcis-1883	85	11	death	death	NOUN
fcis-1883	85	12	in	in	ADP
fcis-1883	85	13	vivo	vivo	NOUN
fcis-1883	85	14	,	,	PUNCT
fcis-1883	85	15	while	while	SCONJ
fcis-1883	85	16	cyclophilin	cyclophilin	PROPN
fcis-1883	85	17	d	d	PROPN
fcis-1883	85	18	overexpression	overexpression	NOUN
fcis-1883	85	19	mice	mouse	NOUN
fcis-1883	85	20	showed	show	VERB
fcis-1883	85	21	mitochondrial	mitochondrial	ADJ
fcis-1883	85	22	swelling	swelling	NOUN
fcis-1883	85	23	and	and	CCONJ
fcis-1883	85	24	spontaneous	spontaneous	ADJ
fcis-1883	85	25	cell	cell	NOUN
fcis-1883	85	26	death	death	NOUN
fcis-1883	85	27	.	.	PUNCT
fcis-1883	86	1	from	from	ADP
fcis-1883	86	2	this	this	DET
fcis-1883	86	3	group	group	NOUN
fcis-1883	86	4	of	of	ADP
fcis-1883	86	5	experiments	experiment	NOUN
fcis-1883	86	6	,	,	PUNCT
fcis-1883	86	7	we	we	PRON
fcis-1883	86	8	can	can	AUX
fcis-1883	86	9	draw	draw	VERB
fcis-1883	86	10	a	a	DET
fcis-1883	86	11	conclusion	conclusion	NOUN
fcis-1883	86	12	that	that	SCONJ
fcis-1883	86	13	cyclophilin	cyclophilin	PROPN
fcis-1883	86	14	d	d	NOUN
fcis-1883	86	15	and	and	CCONJ
fcis-1883	86	16	mitochondrial	mitochondrial	ADJ
fcis-1883	86	17	permeability	permeability	NOUN
fcis-1883	86	18	transition	transition	NOUN
fcis-1883	86	19	are	be	AUX
fcis-1883	86	20	important	important	ADJ
fcis-1883	86	21	mediating	mediate	VERB
fcis-1883	86	22	mechanisms	mechanism	NOUN
fcis-1883	86	23	of	of	ADP
fcis-1883	86	24	calcium	calcium	NOUN
fcis-1883	86	25	overload	overload	NOUN
fcis-1883	86	26	induced	induce	VERB
fcis-1883	86	27	cell	cell	NOUN
fcis-1883	86	28	death	death	NOUN
fcis-1883	86	29	.	.	PUNCT
fcis-1883	87	1	3.2	3.2	NUM
fcis-1883	87	2	.	.	PUNCT
fcis-1883	87	3	hypercontract	hypercontract	NOUN
fcis-1883	87	4	at	at	ADP
fcis-1883	87	5	present	present	ADJ
fcis-1883	87	6	,	,	PUNCT
fcis-1883	87	7	the	the	DET
fcis-1883	87	8	mechanism	mechanism	NOUN
fcis-1883	87	9	of	of	ADP
fcis-1883	87	10	excessive	excessive	ADJ
fcis-1883	87	11	contraction	contraction	NOUN
fcis-1883	87	12	of	of	ADP
fcis-1883	87	13	cardiomyocytes	cardiomyocyte	NOUN
fcis-1883	87	14	is	be	AUX
fcis-1883	87	15	controversial	controversial	ADJ
fcis-1883	87	16	,	,	PUNCT
fcis-1883	87	17	mainly	mainly	ADV
fcis-1883	87	18	including	include	VERB
fcis-1883	87	19	energy	energy	NOUN
fcis-1883	87	20	dependence	dependence	NOUN
fcis-1883	87	21	and	and	CCONJ
fcis-1883	87	22	induction	induction	NOUN
fcis-1883	87	23	of	of	ADP
fcis-1883	87	24	intracellular	intracellular	ADJ
fcis-1883	87	25	ca2	ca2	PROPN
fcis-1883	87	26	+	+	NOUN
fcis-1883	87	27	overload	overload	NOUN
fcis-1883	87	28	.	.	PUNCT
fcis-1883	88	1	nuclear	nuclear	ADJ
fcis-1883	88	2	magnetic	magnetic	ADJ
fcis-1883	88	3	resonance	resonance	NOUN
fcis-1883	88	4	spectroscopy	spectroscopy	NOUN
fcis-1883	88	5	shows	show	VERB
fcis-1883	88	6	that	that	SCONJ
fcis-1883	88	7	after	after	ADP
fcis-1883	88	8	transient	transient	ADJ
fcis-1883	88	9	ischemia	ischemia	NOUN
fcis-1883	88	10	,	,	PUNCT
fcis-1883	88	11	energy	energy	NOUN
fcis-1883	88	12	recovery	recovery	NOUN
fcis-1883	88	13	is	be	AUX
fcis-1883	88	14	rapid	rapid	ADJ
fcis-1883	88	15	and	and	CCONJ
fcis-1883	88	16	nearly	nearly	ADV
fcis-1883	88	17	complete	complete	ADJ
fcis-1883	88	18	,	,	PUNCT
fcis-1883	88	19	but	but	CCONJ
fcis-1883	88	20	the	the	DET
fcis-1883	88	21	heart	heart	NOUN
fcis-1883	88	22	still	still	ADV
fcis-1883	88	23	has	have	VERB
fcis-1883	88	24	excessive	excessive	ADJ
fcis-1883	88	25	contraction	contraction	NOUN
fcis-1883	88	26	and	and	CCONJ
fcis-1883	88	27	verification	verification	NOUN
fcis-1883	88	28	necrosis	necrosis	NOUN
fcis-1883	88	29	[	[	X
fcis-1883	88	30	21	21	NUM
fcis-1883	88	31	]	]	PUNCT
fcis-1883	88	32	.	.	PUNCT
fcis-1883	89	1	this	this	PRON
fcis-1883	89	2	shows	show	VERB
fcis-1883	89	3	that	that	SCONJ
fcis-1883	89	4	the	the	DET
fcis-1883	89	5	excessive	excessive	ADJ
fcis-1883	89	6	contraction	contraction	NOUN
fcis-1883	89	7	of	of	ADP
fcis-1883	89	8	myocardial	myocardial	ADJ
fcis-1883	89	9	cells	cell	NOUN
fcis-1883	89	10	is	be	AUX
fcis-1883	89	11	not	not	PART
fcis-1883	89	12	caused	cause	VERB
fcis-1883	89	13	by	by	ADP
fcis-1883	89	14	low	low	ADJ
fcis-1883	89	15	atp	atp	PROPN
fcis-1883	89	16	level	level	NOUN
fcis-1883	89	17	.	.	PUNCT
fcis-1883	90	1	however	however	ADV
fcis-1883	90	2	,	,	PUNCT
fcis-1883	90	3	piper	piper	NOUN
fcis-1883	90	4	et	et	PROPN
fcis-1883	90	5	al	al	PROPN
fcis-1883	90	6	.	.	PROPN
fcis-1883	90	7	said	say	VERB
fcis-1883	90	8	that	that	SCONJ
fcis-1883	90	9	cytoplasmic	cytoplasmic	ADJ
fcis-1883	90	10	ca2	ca2	PROPN
fcis-1883	90	11	+	+	PROPN
fcis-1883	90	12	oscillations	oscillation	NOUN
fcis-1883	90	13	can	can	AUX
fcis-1883	90	14	cause	cause	VERB
fcis-1883	90	15	sustained	sustained	ADJ
fcis-1883	90	16	and	and	CCONJ
fcis-1883	90	17	uncontrolled	uncontrolled	ADJ
fcis-1883	90	18	activation	activation	NOUN
fcis-1883	90	19	of	of	ADP
fcis-1883	90	20	the	the	DET
fcis-1883	90	21	contractile	contractile	NOUN
fcis-1883	90	22	apparatus	apparatus	NOUN
fcis-1883	90	23	,	,	PUNCT
fcis-1883	90	24	resulting	result	VERB
fcis-1883	90	25	in	in	ADP
fcis-1883	90	26	excessive	excessive	ADJ
fcis-1883	90	27	contraction	contraction	NOUN
fcis-1883	91	1	[	[	X
fcis-1883	91	2	22	22	NUM
fcis-1883	91	3	]	]	PUNCT
fcis-1883	91	4	.	.	PUNCT
fcis-1883	92	1	in	in	ADP
fcis-1883	92	2	tissue	tissue	NOUN
fcis-1883	92	3	,	,	PUNCT
fcis-1883	92	4	the	the	DET
fcis-1883	92	5	mechanical	mechanical	ADJ
fcis-1883	92	6	force	force	NOUN
fcis-1883	92	7	generated	generate	VERB
fcis-1883	92	8	by	by	ADP
fcis-1883	92	9	the	the	DET
fcis-1883	92	10	excessive	excessive	ADJ
fcis-1883	92	11	contraction	contraction	NOUN
fcis-1883	92	12	of	of	ADP
fcis-1883	92	13	adjacent	adjacent	ADJ
fcis-1883	92	14	cells	cell	NOUN
fcis-1883	92	15	will	will	AUX
fcis-1883	92	16	lead	lead	VERB
fcis-1883	92	17	to	to	ADP
fcis-1883	92	18	the	the	DET
fcis-1883	92	19	decomposition	decomposition	NOUN
fcis-1883	92	20	and	and	CCONJ
fcis-1883	92	21	necrosis	necrosis	NOUN
fcis-1883	92	22	of	of	ADP
fcis-1883	92	23	the	the	DET
fcis-1883	92	24	interacting	interact	VERB
fcis-1883	92	25	adjacent	adjacent	ADJ
fcis-1883	92	26	cells	cell	NOUN
fcis-1883	92	27	[	[	X
fcis-1883	92	28	23	23	NUM
fcis-1883	92	29	]	]	PUNCT
fcis-1883	92	30	.	.	PUNCT
fcis-1883	93	1	therefore	therefore	ADV
fcis-1883	93	2	,	,	PUNCT
fcis-1883	93	3	we	we	PRON
fcis-1883	93	4	can	can	AUX
fcis-1883	93	5	further	far	ADV
fcis-1883	93	6	confirm	confirm	VERB
fcis-1883	93	7	the	the	DET
fcis-1883	93	8	mechanism	mechanism	NOUN
fcis-1883	93	9	that	that	PRON
fcis-1883	93	10	calcium	calcium	NOUN
fcis-1883	93	11	overload	overload	NOUN
fcis-1883	93	12	induces	induce	VERB
fcis-1883	93	13	excessive	excessive	ADJ
fcis-1883	93	14	contraction	contraction	NOUN
fcis-1883	93	15	of	of	ADP
fcis-1883	93	16	myocardial	myocardial	ADJ
fcis-1883	93	17	cells	cell	NOUN
fcis-1883	93	18	,	,	PUNCT
fcis-1883	93	19	and	and	CCONJ
fcis-1883	93	20	induces	induce	VERB
fcis-1883	93	21	cell	cell	NOUN
fcis-1883	93	22	lysis	lysis	NOUN
fcis-1883	93	23	and	and	CCONJ
fcis-1883	93	24	necrosis	necrosis	NOUN
fcis-1883	93	25	.	.	PUNCT
fcis-1883	94	1	3.3	3.3	NUM
fcis-1883	94	2	.	.	PUNCT
fcis-1883	95	1	calpain	calpain	NOUN
fcis-1883	95	2	mediated	mediate	VERB
fcis-1883	95	3	protein	protein	NOUN
fcis-1883	95	4	hydrolysis	hydrolysis	NOUN
fcis-1883	95	5	calpain	calpain	NOUN
fcis-1883	95	6	is	be	AUX
fcis-1883	95	7	an	an	DET
fcis-1883	95	8	enzyme	enzyme	NOUN
fcis-1883	95	9	that	that	PRON
fcis-1883	95	10	degrades	degrade	VERB
fcis-1883	95	11	proteins	protein	NOUN
fcis-1883	95	12	.	.	PUNCT
fcis-1883	96	1	calpain	calpain	NOUN
fcis-1883	96	2	activity	activity	NOUN
fcis-1883	96	3	is	be	AUX
fcis-1883	96	4	affected	affect	VERB
fcis-1883	96	5	by	by	ADP
fcis-1883	96	6	the	the	DET
fcis-1883	96	7	concentration	concentration	NOUN
fcis-1883	96	8	of	of	ADP
fcis-1883	96	9	calcium	calcium	NOUN
fcis-1883	96	10	ions	ion	NOUN
fcis-1883	96	11	in	in	ADP
fcis-1883	96	12	muscle	muscle	NOUN
fcis-1883	96	13	cells	cell	NOUN
fcis-1883	96	14	.	.	PUNCT
fcis-1883	97	1	calcium	calcium	NOUN
fcis-1883	97	2	ions	ion	NOUN
fcis-1883	97	3	can	can	AUX
fcis-1883	97	4	activate	activate	VERB
fcis-1883	97	5	this	this	DET
fcis-1883	97	6	protein	protein	NOUN
fcis-1883	97	7	.	.	PUNCT
fcis-1883	98	1	it	it	PRON
fcis-1883	98	2	can	can	AUX
fcis-1883	98	3	degrade	degrade	VERB
fcis-1883	98	4	proteins	protein	NOUN
fcis-1883	98	5	in	in	ADP
fcis-1883	98	6	myofibrils	myofibril	NOUN
fcis-1883	98	7	,	,	PUNCT
fcis-1883	98	8	mainly	mainly	ADV
fcis-1883	98	9	including	include	VERB
fcis-1883	98	10	cytoskeleton	cytoskeleton	NOUN
fcis-1883	98	11	,	,	PUNCT
fcis-1883	98	12	mitochondrial	mitochondrial	ADJ
fcis-1883	98	13	proteins	protein	NOUN
fcis-1883	98	14	and	and	CCONJ
fcis-1883	98	15	endoplasmic	endoplasmic	ADJ
fcis-1883	98	16	reticulum	reticulum	NOUN
fcis-1883	98	17	.	.	PUNCT
fcis-1883	99	1	the	the	DET
fcis-1883	99	2	increase	increase	NOUN
fcis-1883	99	3	of	of	ADP
fcis-1883	99	4	ca2	ca2	PROPN
fcis-1883	99	5	+	+	SYM
fcis-1883	99	6	level	level	NOUN
fcis-1883	99	7	induced	induce	VERB
fcis-1883	99	8	by	by	ADP
fcis-1883	99	9	tissue	tissue	NOUN
fcis-1883	99	10	ischemia	ischemia	NOUN
fcis-1883	99	11	/	/	SYM
fcis-1883	99	12	reperfusion	reperfusion	NOUN
fcis-1883	99	13	can	can	AUX
fcis-1883	99	14	also	also	ADV
fcis-1883	99	15	lead	lead	VERB
fcis-1883	99	16	to	to	ADP
fcis-1883	99	17	pathological	pathological	ADJ
fcis-1883	99	18	activation	activation	NOUN
fcis-1883	99	19	of	of	ADP
fcis-1883	99	20	calpain	calpain	NOUN
fcis-1883	99	21	[	[	X
fcis-1883	99	22	17	17	NUM
fcis-1883	99	23	]	]	PUNCT
fcis-1883	99	24	.	.	PUNCT
fcis-1883	100	1	yoshikawa	yoshikawa	PROPN
fcis-1883	100	2	et	et	PROPN
fcis-1883	100	3	al	al	PROPN
fcis-1883	100	4	.	.	PROPN
fcis-1883	100	5	conducted	conduct	VERB
fcis-1883	100	6	experiments	experiment	NOUN
fcis-1883	100	7	on	on	ADP
fcis-1883	100	8	the	the	DET
fcis-1883	100	9	effects	effect	NOUN
fcis-1883	100	10	of	of	ADP
fcis-1883	100	11	rat	rat	NOUN
fcis-1883	100	12	heart	heart	NOUN
fcis-1883	100	13	ischemia	ischemia	NOUN
fcis-1883	100	14	reperfusion	reperfusion	NOUN
fcis-1883	100	15	on	on	ADP
fcis-1883	100	16	left	left	ADJ
fcis-1883	100	17	ventricular	ventricular	ADJ
fcis-1883	100	18	mechanical	mechanical	ADJ
fcis-1883	100	19	work	work	NOUN
fcis-1883	100	20	and	and	CCONJ
fcis-1883	100	21	energetics	energetic	NOUN
fcis-1883	100	22	,	,	PUNCT
fcis-1883	100	23	which	which	PRON
fcis-1883	100	24	showed	show	VERB
fcis-1883	100	25	that	that	SCONJ
fcis-1883	100	26	calpain	calpain	NOUN
fcis-1883	100	27	hydrolyzed	hydrolyze	VERB
fcis-1883	100	28	the	the	DET
fcis-1883	100	29	lining	lining	NOUN
fcis-1883	100	30	protein	protein	NOUN
fcis-1883	100	31	(	(	PUNCT
fcis-1883	100	32	a	a	DET
fcis-1883	100	33	-	-	PUNCT
fcis-1883	100	34	fodrin	fodrin	NOUN
fcis-1883	100	35	)	)	PUNCT
fcis-1883	100	36	and	and	CCONJ
fcis-1883	100	37	anchor	anchor	NOUN
fcis-1883	100	38	protein	protein	NOUN
fcis-1883	100	39	(	(	PUNCT
fcis-1883	100	40	ankyrin	ankyrin	ADJ
fcis-1883	100	41	)	)	PUNCT
fcis-1883	100	42	from	from	ADP
fcis-1883	100	43	the	the	DET
fcis-1883	100	44	sarcolemma	sarcolemma	PROPN
fcis-1883	100	45	and	and	CCONJ
fcis-1883	100	46	cytoskeleton	cytoskeleton	PROPN
fcis-1883	100	47	,	,	PUNCT
fcis-1883	100	48	reduced	reduce	VERB
fcis-1883	100	49	the	the	DET
fcis-1883	100	50	tolerance	tolerance	NOUN
fcis-1883	100	51	of	of	ADP
fcis-1883	100	52	the	the	DET
fcis-1883	100	53	sarcolemma	sarcolemma	PROPN
fcis-1883	100	54	to	to	ADP
fcis-1883	100	55	the	the	DET
fcis-1883	100	56	mechanical	mechanical	ADJ
fcis-1883	100	57	stress	stress	NOUN
fcis-1883	100	58	related	relate	VERB
fcis-1883	100	59	to	to	ADP
fcis-1883	100	60	excessive	excessive	ADJ
fcis-1883	100	61	contraction	contraction	NOUN
fcis-1883	100	62	and	and	CCONJ
fcis-1883	100	63	acute	acute	ADJ
fcis-1883	100	64	cell	cell	NOUN
fcis-1883	100	65	swelling	swell	VERB
fcis-1883	100	66	during	during	ADP
fcis-1883	100	67	reperfusion	reperfusion	NOUN
fcis-1883	100	68	,	,	PUNCT
fcis-1883	100	69	and	and	CCONJ
fcis-1883	100	70	increased	increase	VERB
fcis-1883	100	71	the	the	DET
fcis-1883	100	72	vulnerability	vulnerability	NOUN
fcis-1883	100	73	of	of	ADP
fcis-1883	100	74	the	the	DET
fcis-1883	100	75	sarcolemma	sarcolemma	PROPN
fcis-1883	101	1	[	[	X
fcis-1883	101	2	24	24	NUM
fcis-1883	101	3	]	]	PUNCT
fcis-1883	101	4	.	.	PUNCT
fcis-1883	102	1	anchoring	anchor	VERB
fcis-1883	102	2	proteins	protein	NOUN
fcis-1883	102	3	have	have	VERB
fcis-1883	102	4	a	a	DET
fcis-1883	102	5	central	central	ADJ
fcis-1883	102	6	domain	domain	NOUN
fcis-1883	102	7	that	that	PRON
fcis-1883	102	8	binds	bind	VERB
fcis-1883	102	9	to	to	ADP
fcis-1883	102	10	the	the	DET
fcis-1883	102	11	lining	lining	NOUN
fcis-1883	102	12	protein	protein	NOUN
fcis-1883	102	13	and	and	CCONJ
fcis-1883	102	14	an	an	DET
fcis-1883	102	15	n	n	CCONJ
fcis-1883	102	16	-	-	PUNCT
fcis-1883	102	17	terminal	terminal	ADJ
fcis-1883	102	18	domain	domain	NOUN
fcis-1883	102	19	that	that	PRON
fcis-1883	102	20	interacts	interact	VERB
fcis-1883	102	21	with	with	ADP
fcis-1883	102	22	a	a	DET
fcis-1883	102	23	variety	variety	NOUN
fcis-1883	102	24	of	of	ADP
fcis-1883	102	25	receptors	receptor	NOUN
fcis-1883	102	26	and	and	CCONJ
fcis-1883	102	27	channels	channel	NOUN
fcis-1883	102	28	,	,	PUNCT
fcis-1883	102	29	including	include	VERB
fcis-1883	102	30	na+/k+	na+/k+	NOUN
fcis-1883	102	31	pump	pump	NOUN
fcis-1883	102	32	subunits	subunit	NOUN
fcis-1883	102	33	.	.	PUNCT
fcis-1883	103	1	na+/k+	na+/k+	PROPN
fcis-1883	103	2	pump	pump	PROPN
fcis-1883	103	3	can	can	AUX
fcis-1883	103	4	be	be	AUX
fcis-1883	103	5	connected	connect	VERB
fcis-1883	103	6	to	to	ADP
fcis-1883	103	7	the	the	DET
fcis-1883	103	8	membrane	membrane	NOUN
fcis-1883	103	9	cytoskeleton	cytoskeleton	NOUN
fcis-1883	103	10	based	base	VERB
fcis-1883	103	11	on	on	ADP
fcis-1883	103	12	fodrin	fodrin	NOUN
fcis-1883	103	13	by	by	ADP
fcis-1883	103	14	binding	bind	VERB
fcis-1883	103	15	with	with	ADP
fcis-1883	103	16	anchoring	anchor	VERB
fcis-1883	103	17	protein	protein	NOUN
fcis-1883	103	18	.	.	PUNCT
fcis-1883	104	1	in	in	ADP
fcis-1883	104	2	addition	addition	NOUN
fcis-1883	104	3	,	,	PUNCT
fcis-1883	104	4	activated	activate	VERB
fcis-1883	104	5	calpain	calpain	NOUN
fcis-1883	104	6	can	can	AUX
fcis-1883	104	7	induce	induce	VERB
fcis-1883	104	8	the	the	DET
fcis-1883	104	9	release	release	NOUN
fcis-1883	104	10	of	of	ADP
fcis-1883	104	11	a	a	DET
fcis-1883	104	12	variety	variety	NOUN
fcis-1883	104	13	of	of	ADP
fcis-1883	104	14	pro	pro	ADJ
fcis-1883	104	15	apoptotic	apoptotic	ADJ
fcis-1883	104	16	factors	factor	NOUN
fcis-1883	104	17	,	,	PUNCT
fcis-1883	104	18	including	include	VERB
fcis-1883	104	19	cytochrome	cytochrome	PROPN
fcis-1883	104	20	c.	c.	PROPN
fcis-1883	104	21	huss	huss	PROPN
fcis-1883	104	22	r	r	PROPN
fcis-1883	104	23	et	et	PROPN
fcis-1883	104	24	al	al	PROPN
fcis-1883	104	25	.	.	PUNCT
fcis-1883	105	1	[	[	X
fcis-1883	105	2	26	26	NUM
fcis-1883	105	3	]	]	PUNCT
fcis-1883	105	4	proved	prove	VERB
fcis-1883	105	5	through	through	ADP
fcis-1883	105	6	experiments	experiment	NOUN
fcis-1883	105	7	that	that	SCONJ
fcis-1883	105	8	inhibition	inhibition	NOUN
fcis-1883	105	9	of	of	ADP
fcis-1883	105	10	calpain	calpain	NOUN
fcis-1883	105	11	activity	activity	NOUN
fcis-1883	105	12	can	can	AUX
fcis-1883	105	13	reduce	reduce	VERB
fcis-1883	105	14	the	the	DET
fcis-1883	105	15	infarct	infarct	ADJ
fcis-1883	105	16	size	size	NOUN
fcis-1883	105	17	of	of	ADP
fcis-1883	105	18	different	different	ADJ
fcis-1883	105	19	models	model	NOUN
fcis-1883	105	20	,	,	PUNCT
fcis-1883	105	21	and	and	CCONJ
fcis-1883	105	22	the	the	DET
fcis-1883	105	23	pharmacological	pharmacological	ADJ
fcis-1883	105	24	inhibition	inhibition	NOUN
fcis-1883	105	25	of	of	ADP
fcis-1883	105	26	calpain	calpain	NOUN
fcis-1883	105	27	can	can	AUX
fcis-1883	105	28	play	play	VERB
fcis-1883	105	29	a	a	DET
fcis-1883	105	30	protective	protective	ADJ
fcis-1883	105	31	role	role	NOUN
fcis-1883	105	32	in	in	ADP
fcis-1883	105	33	the	the	DET
fcis-1883	105	34	myocardium	myocardium	NOUN
fcis-1883	105	35	.	.	PUNCT
fcis-1883	106	1	3.4	3.4	NUM
fcis-1883	106	2	.	.	PUNCT
fcis-1883	106	3	apoptosis	apoptosis	NOUN
fcis-1883	106	4	and	and	CCONJ
fcis-1883	106	5	necrosis	necrosis	NOUN
fcis-1883	106	6	apoptosis	apoptosis	NOUN
fcis-1883	106	7	,	,	PUNCT
fcis-1883	106	8	also	also	ADV
fcis-1883	106	9	known	know	VERB
fcis-1883	106	10	as	as	ADP
fcis-1883	106	11	programmed	program	VERB
fcis-1883	106	12	cell	cell	NOUN
fcis-1883	106	13	death	death	NOUN
fcis-1883	106	14	,	,	PUNCT
fcis-1883	106	15	is	be	AUX
fcis-1883	106	16	caused	cause	VERB
fcis-1883	106	17	by	by	ADP
fcis-1883	106	18	the	the	DET
fcis-1883	106	19	enzymatic	enzymatic	ADJ
fcis-1883	106	20	hydrolysis	hydrolysis	NOUN
fcis-1883	106	21	of	of	ADP
fcis-1883	106	22	cells	cell	NOUN
fcis-1883	106	23	due	due	ADP
fcis-1883	106	24	to	to	ADP
fcis-1883	106	25	the	the	DET
fcis-1883	106	26	activation	activation	NOUN
fcis-1883	106	27	of	of	ADP
fcis-1883	106	28	apoptosis	apoptosis	NOUN
fcis-1883	106	29	proteins	protein	NOUN
fcis-1883	106	30	by	by	ADP
fcis-1883	106	31	a	a	DET
fcis-1883	106	32	variety	variety	NOUN
fcis-1883	106	33	of	of	ADP
fcis-1883	106	34	apoptosis	apoptosis	NOUN
fcis-1883	106	35	factors	factor	NOUN
fcis-1883	106	36	.	.	PUNCT
fcis-1883	107	1	calcium	calcium	NOUN
fcis-1883	107	2	overload	overload	NOUN
fcis-1883	107	3	is	be	AUX
fcis-1883	107	4	also	also	ADV
fcis-1883	107	5	an	an	DET
fcis-1883	107	6	important	important	ADJ
fcis-1883	107	7	factor	factor	NOUN
fcis-1883	107	8	that	that	PRON
fcis-1883	107	9	can	can	AUX
fcis-1883	107	10	stimulate	stimulate	VERB
fcis-1883	107	11	programmed	programmed	ADJ
fcis-1883	107	12	cell	cell	NOUN
fcis-1883	107	13	death	death	NOUN
fcis-1883	107	14	through	through	ADP
fcis-1883	107	15	a	a	DET
fcis-1883	107	16	series	series	NOUN
fcis-1883	107	17	of	of	ADP
fcis-1883	107	18	signal	signal	ADJ
fcis-1883	107	19	transduction	transduction	NOUN
fcis-1883	107	20	.	.	PUNCT
fcis-1883	108	1	it	it	PRON
fcis-1883	108	2	can	can	AUX
fcis-1883	108	3	induce	induce	VERB
fcis-1883	108	4	the	the	DET
fcis-1883	108	5	generation	generation	NOUN
fcis-1883	108	6	of	of	ADP
fcis-1883	108	7	death	death	NOUN
fcis-1883	108	8	ligands	ligand	NOUN
fcis-1883	108	9	such	such	ADJ
fcis-1883	108	10	as	as	ADP
fcis-1883	108	11	tumor	tumor	NOUN
fcis-1883	108	12	77	77	NUM
fcis-1883	108	13	necrosis	necrosis	NOUN
fcis-1883	108	14	factor	factor	NOUN
fcis-1883	108	15	,	,	PUNCT
fcis-1883	108	16	which	which	PRON
fcis-1883	108	17	can	can	AUX
fcis-1883	108	18	activate	activate	VERB
fcis-1883	108	19	the	the	DET
fcis-1883	108	20	apoptosis	apoptosis	NOUN
fcis-1883	108	21	process	process	NOUN
fcis-1883	108	22	by	by	ADP
fcis-1883	108	23	binding	bind	VERB
fcis-1883	108	24	with	with	ADP
fcis-1883	108	25	corresponding	correspond	VERB
fcis-1883	108	26	receptors	receptor	NOUN
fcis-1883	108	27	.	.	PUNCT
fcis-1883	109	1	at	at	ADP
fcis-1883	109	2	the	the	DET
fcis-1883	109	3	same	same	ADJ
fcis-1883	109	4	time	time	NOUN
fcis-1883	109	5	,	,	PUNCT
fcis-1883	109	6	calcium	calcium	NOUN
fcis-1883	109	7	overload	overload	NOUN
fcis-1883	109	8	can	can	AUX
fcis-1883	109	9	also	also	ADV
fcis-1883	109	10	induce	induce	VERB
fcis-1883	109	11	the	the	DET
fcis-1883	109	12	programmed	programmed	ADJ
fcis-1883	109	13	cell	cell	NOUN
fcis-1883	109	14	death	death	NOUN
fcis-1883	109	15	by	by	ADP
fcis-1883	109	16	activating	activate	VERB
fcis-1883	109	17	calmodulin	calmodulin	NOUN
fcis-1883	109	18	kinase	kinase	NOUN
fcis-1883	109	19	and	and	CCONJ
fcis-1883	109	20	stimulating	stimulate	VERB
fcis-1883	109	21	mitochondria	mitochondria	NOUN
fcis-1883	109	22	to	to	PART
fcis-1883	109	23	release	release	VERB
fcis-1883	109	24	apoptosis	apoptosis	NOUN
fcis-1883	109	25	promoting	promote	VERB
fcis-1883	109	26	proteins	protein	NOUN
fcis-1883	109	27	[	[	X
fcis-1883	109	28	27	27	NUM
fcis-1883	109	29	]	]	PUNCT
fcis-1883	109	30	.	.	PUNCT
fcis-1883	110	1	in	in	ADP
fcis-1883	110	2	ischemiareperfusion	ischemiareperfusion	NOUN
fcis-1883	110	3	tissues	tissue	NOUN
fcis-1883	110	4	,	,	PUNCT
fcis-1883	110	5	the	the	DET
fcis-1883	110	6	increase	increase	NOUN
fcis-1883	110	7	of	of	ADP
fcis-1883	110	8	intracellular	intracellular	ADJ
fcis-1883	110	9	calcium	calcium	NOUN
fcis-1883	110	10	concentration	concentration	NOUN
fcis-1883	110	11	can	can	AUX
fcis-1883	110	12	also	also	ADV
fcis-1883	110	13	lead	lead	VERB
fcis-1883	110	14	to	to	ADP
fcis-1883	110	15	the	the	DET
fcis-1883	110	16	formation	formation	NOUN
fcis-1883	110	17	of	of	ADP
fcis-1883	110	18	calcium	calcium	NOUN
fcis-1883	110	19	pyrophosphate	pyrophosphate	NOUN
fcis-1883	110	20	complex	complex	NOUN
fcis-1883	110	21	and	and	CCONJ
fcis-1883	110	22	urea	urea	NOUN
fcis-1883	110	23	in	in	ADP
fcis-1883	110	24	cells	cell	NOUN
fcis-1883	110	25	.	.	PUNCT
fcis-1883	111	1	these	these	DET
fcis-1883	111	2	components	component	NOUN
fcis-1883	111	3	can	can	AUX
fcis-1883	111	4	activate	activate	VERB
fcis-1883	111	5	inflammatory	inflammatory	ADJ
fcis-1883	111	6	bodies	body	NOUN
fcis-1883	111	7	to	to	PART
fcis-1883	111	8	make	make	VERB
fcis-1883	111	9	il-1	il-1	PRON
fcis-1883	111	10	β	β	PROPN
fcis-1883	111	11	and	and	CCONJ
fcis-1883	111	12	tnf	tnf	PROPN
fcis-1883	111	13	α	α	PROPN
fcis-1883	111	14	and	and	CCONJ
fcis-1883	111	15	other	other	ADJ
fcis-1883	111	16	cytokines	cytokine	NOUN
fcis-1883	111	17	begin	begin	VERB
fcis-1883	111	18	to	to	PART
fcis-1883	111	19	be	be	AUX
fcis-1883	111	20	produced	produce	VERB
fcis-1883	111	21	,	,	PUNCT
fcis-1883	111	22	which	which	PRON
fcis-1883	111	23	aggravates	aggravate	VERB
fcis-1883	111	24	the	the	DET
fcis-1883	111	25	tissue	tissue	NOUN
fcis-1883	111	26	ischemia	ischemia	NOUN
fcis-1883	111	27	-	-	PUNCT
fcis-1883	111	28	reperfusion	reperfusion	NOUN
fcis-1883	111	29	injury	injury	NOUN
fcis-1883	111	30	.	.	PUNCT
fcis-1883	112	1	these	these	DET
fcis-1883	112	2	factors	factor	NOUN
fcis-1883	112	3	can	can	AUX
fcis-1883	112	4	also	also	ADV
fcis-1883	112	5	reverse	reverse	VERB
fcis-1883	112	6	activate	activate	VERB
fcis-1883	112	7	a	a	DET
fcis-1883	112	8	variety	variety	NOUN
fcis-1883	112	9	of	of	ADP
fcis-1883	112	10	transcription	transcription	NOUN
fcis-1883	112	11	factors	factor	NOUN
fcis-1883	112	12	,	,	PUNCT
fcis-1883	112	13	including	include	VERB
fcis-1883	112	14	nfkb	nfkb	PROPN
fcis-1883	112	15	,	,	PUNCT
fcis-1883	112	16	and	and	CCONJ
fcis-1883	112	17	promote	promote	VERB
fcis-1883	112	18	the	the	DET
fcis-1883	112	19	expression	expression	NOUN
fcis-1883	112	20	of	of	ADP
fcis-1883	112	21	chemokines	chemokine	NOUN
fcis-1883	112	22	and	and	CCONJ
fcis-1883	112	23	cytokines	cytokine	NOUN
fcis-1883	112	24	,	,	PUNCT
fcis-1883	112	25	leading	lead	VERB
fcis-1883	112	26	to	to	ADP
fcis-1883	112	27	further	further	ADJ
fcis-1883	112	28	inflammation	inflammation	NOUN
fcis-1883	112	29	and	and	CCONJ
fcis-1883	112	30	further	further	ADJ
fcis-1883	112	31	cell	cell	NOUN
fcis-1883	112	32	damage	damage	NOUN
fcis-1883	112	33	,	,	PUNCT
fcis-1883	112	34	thus	thus	ADV
fcis-1883	112	35	forming	form	VERB
fcis-1883	112	36	a	a	DET
fcis-1883	112	37	vicious	vicious	ADJ
fcis-1883	112	38	circle	circle	NOUN
fcis-1883	112	39	and	and	CCONJ
fcis-1883	112	40	causing	cause	VERB
fcis-1883	112	41	necrosis	necrosis	NOUN
fcis-1883	112	42	[	[	X
fcis-1883	112	43	17	17	NUM
fcis-1883	112	44	]	]	PUNCT
fcis-1883	112	45	.	.	PUNCT
fcis-1883	113	1	fig	fig	PROPN
fcis-1883	113	2	2	2	NUM
fcis-1883	113	3	.	.	PUNCT
fcis-1883	113	4	diagram	diagram	NOUN
fcis-1883	113	5	of	of	ADP
fcis-1883	113	6	calcium	calcium	NOUN
fcis-1883	113	7	overload	overload	NOUN
fcis-1883	113	8	in	in	ADP
fcis-1883	113	9	miri	miri	PROPN
fcis-1883	113	10	4	4	NUM
fcis-1883	113	11	.	.	PUNCT
fcis-1883	113	12	conclusion	conclusion	NOUN
fcis-1883	113	13	by	by	ADP
fcis-1883	113	14	studying	study	VERB
fcis-1883	113	15	the	the	DET
fcis-1883	113	16	mechanism	mechanism	NOUN
fcis-1883	113	17	of	of	ADP
fcis-1883	113	18	mi	mi	PROPN
fcis-1883	113	19	-	-	PROPN
fcis-1883	113	20	ri	ri	PROPN
fcis-1883	113	21	and	and	CCONJ
fcis-1883	113	22	better	well	ADV
fcis-1883	113	23	understanding	understand	VERB
fcis-1883	113	24	the	the	DET
fcis-1883	113	25	potential	potential	ADJ
fcis-1883	113	26	signaling	signal	VERB
fcis-1883	113	27	pathways	pathway	NOUN
fcis-1883	113	28	,	,	PUNCT
fcis-1883	113	29	we	we	PRON
fcis-1883	113	30	will	will	AUX
fcis-1883	113	31	have	have	VERB
fcis-1883	113	32	a	a	DET
fcis-1883	113	33	greater	great	ADJ
fcis-1883	113	34	possibility	possibility	NOUN
fcis-1883	113	35	to	to	PART
fcis-1883	113	36	develop	develop	VERB
fcis-1883	113	37	therapeutic	therapeutic	ADJ
fcis-1883	113	38	methods	method	NOUN
fcis-1883	113	39	to	to	PART
fcis-1883	113	40	prevent	prevent	VERB
fcis-1883	113	41	mi	mi	PROPN
fcis-1883	113	42	-	-	PROPN
fcis-1883	113	43	ri	ri	NOUN
fcis-1883	113	44	.	.	PUNCT
fcis-1883	114	1	we	we	PRON
fcis-1883	114	2	look	look	VERB
fcis-1883	114	3	forward	forward	ADV
fcis-1883	114	4	to	to	ADP
fcis-1883	114	5	the	the	DET
fcis-1883	114	6	development	development	NOUN
fcis-1883	114	7	of	of	ADP
fcis-1883	114	8	new	new	ADJ
fcis-1883	114	9	therapies	therapy	NOUN
fcis-1883	114	10	to	to	PART
fcis-1883	114	11	reduce	reduce	VERB
fcis-1883	114	12	myocardial	myocardial	ADJ
fcis-1883	114	13	infarction	infarction	NOUN
fcis-1883	114	14	/	/	SYM
fcis-1883	114	15	reperfusion	reperfusion	NOUN
fcis-1883	114	16	injury	injury	NOUN
fcis-1883	114	17	and	and	CCONJ
fcis-1883	114	18	bring	bring	VERB
fcis-1883	114	19	them	they	PRON
fcis-1883	114	20	into	into	ADP
fcis-1883	114	21	clinical	clinical	ADJ
fcis-1883	114	22	trials	trial	NOUN
fcis-1883	114	23	as	as	ADV
fcis-1883	114	24	soon	soon	ADV
fcis-1883	114	25	as	as	ADP
fcis-1883	114	26	possible	possible	ADJ
fcis-1883	114	27	.	.	PUNCT
fcis-1883	115	1	in	in	ADP
fcis-1883	115	2	a	a	DET
fcis-1883	115	3	word	word	NOUN
fcis-1883	115	4	,	,	PUNCT
fcis-1883	115	5	understanding	understanding	NOUN
fcis-1883	115	6	and	and	CCONJ
fcis-1883	115	7	further	far	ADV
fcis-1883	115	8	studying	study	VERB
fcis-1883	115	9	the	the	DET
fcis-1883	115	10	mechanism	mechanism	NOUN
fcis-1883	115	11	of	of	ADP
fcis-1883	115	12	calcium	calcium	NOUN
fcis-1883	115	13	overload	overload	NOUN
fcis-1883	115	14	and	and	CCONJ
fcis-1883	115	15	the	the	DET
fcis-1883	115	16	mechanism	mechanism	NOUN
fcis-1883	115	17	of	of	ADP
fcis-1883	115	18	causing	cause	VERB
fcis-1883	115	19	mi	mi	PROPN
fcis-1883	115	20	-	-	NOUN
fcis-1883	115	21	ri	ri	PROPN
fcis-1883	115	22	is	be	AUX
fcis-1883	115	23	the	the	DET
fcis-1883	115	24	basis	basis	NOUN
fcis-1883	115	25	for	for	ADP
fcis-1883	115	26	our	our	PRON
fcis-1883	115	27	in	in	ADP
fcis-1883	115	28	-	-	PUNCT
fcis-1883	115	29	depth	depth	NOUN
fcis-1883	115	30	study	study	NOUN
fcis-1883	115	31	of	of	ADP
fcis-1883	115	32	the	the	DET
fcis-1883	115	33	pathogenesis	pathogenesis	NOUN
fcis-1883	115	34	of	of	ADP
fcis-1883	115	35	mi	mi	PROPN
fcis-1883	115	36	-	-	PROPN
fcis-1883	115	37	ri	ri	PROPN
fcis-1883	115	38	.	.	PUNCT
fcis-1883	116	1	a	a	DET
fcis-1883	116	2	large	large	ADJ
fcis-1883	116	3	number	number	NOUN
fcis-1883	116	4	of	of	ADP
fcis-1883	116	5	literatures	literature	NOUN
fcis-1883	116	6	have	have	AUX
fcis-1883	116	7	proved	prove	VERB
fcis-1883	116	8	that	that	SCONJ
fcis-1883	116	9	calcium	calcium	NOUN
fcis-1883	116	10	overload	overload	NOUN
fcis-1883	116	11	occurs	occur	VERB
fcis-1883	116	12	during	during	ADP
fcis-1883	116	13	myocardial	myocardial	ADJ
fcis-1883	116	14	ischemia	ischemia	NOUN
fcis-1883	116	15	reperfusion	reperfusion	NOUN
fcis-1883	116	16	,	,	PUNCT
fcis-1883	116	17	and	and	CCONJ
fcis-1883	116	18	calcium	calcium	NOUN
fcis-1883	116	19	overload	overload	NOUN
fcis-1883	116	20	can	can	AUX
fcis-1883	116	21	further	far	ADV
fcis-1883	116	22	aggravate	aggravate	VERB
fcis-1883	116	23	myocardial	myocardial	ADJ
fcis-1883	116	24	ischemia	ischemia	NOUN
fcis-1883	116	25	reperfusion	reperfusion	NOUN
fcis-1883	116	26	injury	injury	NOUN
fcis-1883	116	27	.	.	PUNCT
fcis-1883	117	1	therefore	therefore	ADV
fcis-1883	117	2	,	,	PUNCT
fcis-1883	117	3	we	we	PRON
fcis-1883	117	4	can	can	AUX
fcis-1883	117	5	study	study	VERB
fcis-1883	117	6	the	the	DET
fcis-1883	117	7	mechanism	mechanism	NOUN
fcis-1883	117	8	of	of	ADP
fcis-1883	117	9	calcium	calcium	NOUN
fcis-1883	117	10	overload	overload	NOUN
fcis-1883	117	11	and	and	CCONJ
fcis-1883	117	12	the	the	DET
fcis-1883	117	13	mechanism	mechanism	NOUN
fcis-1883	117	14	of	of	ADP
fcis-1883	117	15	calcium	calcium	NOUN
fcis-1883	117	16	overload	overload	NOUN
fcis-1883	117	17	aggravating	aggravating	ADJ
fcis-1883	117	18	ischemia	ischemia	NOUN
fcis-1883	117	19	-	-	PUNCT
fcis-1883	117	20	reperfusion	reperfusion	NOUN
fcis-1883	117	21	injury	injury	NOUN
fcis-1883	117	22	.	.	PUNCT
fcis-1883	118	1	inhibiting	inhibit	VERB
fcis-1883	118	2	the	the	DET
fcis-1883	118	3	mechanism	mechanism	NOUN
fcis-1883	118	4	of	of	ADP
fcis-1883	118	5	calcium	calcium	NOUN
fcis-1883	118	6	overload	overload	NOUN
fcis-1883	118	7	and	and	CCONJ
fcis-1883	118	8	blocking	block	VERB
fcis-1883	118	9	the	the	DET
fcis-1883	118	10	mechanism	mechanism	NOUN
fcis-1883	118	11	of	of	ADP
fcis-1883	118	12	calcium	calcium	NOUN
fcis-1883	118	13	overload	overload	NOUN
fcis-1883	118	14	aggravating	aggravating	ADJ
fcis-1883	118	15	injury	injury	NOUN
fcis-1883	118	16	can	can	AUX
fcis-1883	118	17	reduce	reduce	VERB
fcis-1883	118	18	reperfusion	reperfusion	NOUN
fcis-1883	118	19	injury	injury	NOUN
fcis-1883	118	20	and	and	CCONJ
fcis-1883	118	21	protect	protect	VERB
fcis-1883	118	22	myocardial	myocardial	ADJ
fcis-1883	118	23	cells	cell	NOUN
fcis-1883	118	24	.	.	PUNCT
fcis-1883	119	1	the	the	DET
fcis-1883	119	2	mechanisms	mechanism	NOUN
fcis-1883	119	3	reviewed	review	VERB
fcis-1883	119	4	in	in	ADP
fcis-1883	119	5	this	this	DET
fcis-1883	119	6	article	article	NOUN
fcis-1883	119	7	provide	provide	VERB
fcis-1883	119	8	multiple	multiple	ADJ
fcis-1883	119	9	potential	potential	ADJ
fcis-1883	119	10	targets	target	NOUN
fcis-1883	119	11	for	for	ADP
fcis-1883	119	12	the	the	DET
fcis-1883	119	13	prevention	prevention	NOUN
fcis-1883	119	14	and	and	CCONJ
fcis-1883	119	15	treatment	treatment	NOUN
fcis-1883	119	16	of	of	ADP
fcis-1883	119	17	clinical	clinical	ADJ
fcis-1883	119	18	myocardial	myocardial	ADJ
fcis-1883	119	19	infarction	infarction	NOUN
fcis-1883	119	20	.	.	PUNCT
fcis-1883	120	1	at	at	ADP
fcis-1883	120	2	the	the	DET
fcis-1883	120	3	same	same	ADJ
fcis-1883	120	4	time	time	NOUN
fcis-1883	120	5	,	,	PUNCT
fcis-1883	120	6	the	the	DET
fcis-1883	120	7	clinical	clinical	ADJ
fcis-1883	120	8	demand	demand	NOUN
fcis-1883	120	9	is	be	AUX
fcis-1883	120	10	urging	urge	VERB
fcis-1883	120	11	researchers	researcher	NOUN
fcis-1883	120	12	to	to	PART
fcis-1883	120	13	make	make	VERB
fcis-1883	120	14	greater	great	ADJ
fcis-1883	120	15	efforts	effort	NOUN
fcis-1883	120	16	to	to	PART
fcis-1883	120	17	find	find	VERB
fcis-1883	120	18	more	more	ADV
fcis-1883	120	19	effective	effective	ADJ
fcis-1883	120	20	and	and	CCONJ
fcis-1883	120	21	safer	safe	ADJ
fcis-1883	120	22	drugs	drug	NOUN
fcis-1883	120	23	to	to	PART
fcis-1883	120	24	treat	treat	VERB
fcis-1883	120	25	mi	mi	PROPN
fcis-1883	120	26	-	-	PROPN
fcis-1883	120	27	ri	ri	PROPN
fcis-1883	120	28	.	.	PUNCT
fcis-1883	120	29	multi	multi	PROPN
fcis-1883	120	30	target	target	PROPN
fcis-1883	120	31	prevention	prevention	NOUN
fcis-1883	120	32	and	and	CCONJ
fcis-1883	120	33	treatment	treatment	NOUN
fcis-1883	120	34	of	of	ADP
fcis-1883	120	35	mi	mi	PROPN
fcis-1883	120	36	-	-	PROPN
fcis-1883	120	37	ri	ri	PROPN
fcis-1883	120	38	has	have	VERB
fcis-1883	120	39	potential	potential	ADJ
fcis-1883	120	40	application	application	NOUN
fcis-1883	120	41	value	value	NOUN
fcis-1883	120	42	.	.	PUNCT
fcis-1883	121	1	therefore	therefore	ADV
fcis-1883	121	2	,	,	PUNCT
fcis-1883	121	3	to	to	PART
fcis-1883	121	4	study	study	VERB
fcis-1883	121	5	the	the	DET
fcis-1883	121	6	multiple	multiple	ADJ
fcis-1883	121	7	signal	signal	NOUN
fcis-1883	121	8	pathways	pathway	NOUN
fcis-1883	121	9	involved	involve	VERB
fcis-1883	121	10	in	in	ADP
fcis-1883	121	11	myocardial	myocardial	ADJ
fcis-1883	121	12	ischemia	ischemia	NOUN
fcis-1883	121	13	-	-	PUNCT
fcis-1883	121	14	reperfusion	reperfusion	NOUN
fcis-1883	121	15	injury	injury	NOUN
fcis-1883	121	16	;	;	PUNCT
fcis-1883	121	17	to	to	PART
fcis-1883	121	18	clarify	clarify	VERB
fcis-1883	121	19	the	the	DET
fcis-1883	121	20	interaction	interaction	NOUN
fcis-1883	121	21	between	between	ADP
fcis-1883	121	22	various	various	ADJ
fcis-1883	121	23	mechanisms	mechanism	NOUN
fcis-1883	121	24	related	relate	VERB
fcis-1883	121	25	to	to	ADP
fcis-1883	121	26	myocardial	myocardial	ADJ
fcis-1883	121	27	ischemia	ischemia	NOUN
fcis-1883	121	28	-	-	PUNCT
fcis-1883	121	29	reperfusion	reperfusion	NOUN
fcis-1883	121	30	and	and	CCONJ
fcis-1883	121	31	calcium	calcium	NOUN
fcis-1883	121	32	regulation	regulation	NOUN
fcis-1883	121	33	;	;	PUNCT
fcis-1883	121	34	to	to	PART
fcis-1883	121	35	test	test	VERB
fcis-1883	121	36	the	the	DET
fcis-1883	121	37	effect	effect	NOUN
fcis-1883	121	38	of	of	ADP
fcis-1883	121	39	different	different	ADJ
fcis-1883	121	40	calcium	calcium	NOUN
fcis-1883	121	41	channel	channel	NOUN
fcis-1883	121	42	drug	drug	NOUN
fcis-1883	121	43	combinations	combination	NOUN
fcis-1883	121	44	or	or	CCONJ
fcis-1883	121	45	multi	multi	ADJ
fcis-1883	121	46	target	target	NOUN
fcis-1883	121	47	chemosynthetic	chemosynthetic	ADJ
fcis-1883	121	48	drugs	drug	NOUN
fcis-1883	121	49	in	in	ADP
fcis-1883	121	50	mi	mi	PROPN
fcis-1883	121	51	-	-	PROPN
fcis-1883	121	52	ri	ri	PROPN
fcis-1883	121	53	treatment	treatment	NOUN
fcis-1883	121	54	,	,	PUNCT
fcis-1883	121	55	in	in	ADP
fcis-1883	121	56	order	order	NOUN
fcis-1883	121	57	to	to	PART
fcis-1883	121	58	seek	seek	VERB
fcis-1883	121	59	the	the	DET
fcis-1883	121	60	therapeutic	therapeutic	ADJ
fcis-1883	121	61	effect	effect	NOUN
fcis-1883	121	62	of	of	ADP
fcis-1883	121	63	1	1	NUM
fcis-1883	121	64	+	+	NOUN
fcis-1883	121	65	1>2	1>2	NUM
fcis-1883	121	66	.	.	PUNCT
fcis-1883	122	1	it	it	PRON
fcis-1883	122	2	is	be	AUX
fcis-1883	122	3	the	the	DET
fcis-1883	122	4	trend	trend	NOUN
fcis-1883	122	5	and	and	CCONJ
fcis-1883	122	6	direction	direction	NOUN
fcis-1883	122	7	of	of	ADP
fcis-1883	122	8	future	future	ADJ
fcis-1883	122	9	research	research	NOUN
fcis-1883	122	10	.	.	PUNCT
fcis-1883	123	1	acknowledgment	acknowledgment	NOUN
fcis-1883	123	2	this	this	DET
fcis-1883	123	3	study	study	NOUN
fcis-1883	123	4	was	be	AUX
fcis-1883	123	5	supported	support	VERB
fcis-1883	123	6	by	by	ADP
fcis-1883	123	7	provincial	provincial	ADJ
fcis-1883	123	8	science	science	NOUN
fcis-1883	123	9	and	and	CCONJ
fcis-1883	123	10	technology	technology	NOUN
fcis-1883	123	11	grant	grant	NOUN
fcis-1883	123	12	of	of	ADP
fcis-1883	123	13	shanxi	shanxi	PROPN
fcis-1883	123	14	province	province	PROPN
fcis-1883	123	15	(	(	PUNCT
fcis-1883	123	16	20210302124588	20210302124588	NUM
fcis-1883	123	17	)	)	PUNCT
fcis-1883	123	18	,	,	PUNCT
fcis-1883	123	19	science	science	NOUN
fcis-1883	123	20	and	and	CCONJ
fcis-1883	123	21	technology	technology	NOUN
fcis-1883	123	22	innovation	innovation	NOUN
fcis-1883	123	23	project	project	NOUN
fcis-1883	123	24	of	of	ADP
fcis-1883	123	25	shanxi	shanxi	PROPN
fcis-1883	123	26	province	province	PROPN
fcis-1883	123	27	universities	university	NOUN
fcis-1883	123	28	(	(	PUNCT
fcis-1883	123	29	2019l0683	2019l0683	NOUN
fcis-1883	123	30	)	)	PUNCT
fcis-1883	123	31	,	,	PUNCT
fcis-1883	123	32	changzhi	changzhi	PROPN
fcis-1883	123	33	medical	medical	PROPN
fcis-1883	123	34	college	college	PROPN
fcis-1883	123	35	doctoral	doctoral	PROPN
fcis-1883	123	36	startup	startup	NOUN
fcis-1883	123	37	fund	fund	NOUN
fcis-1883	123	38	(	(	PUNCT
fcis-1883	123	39	bs201908	bs201908	PROPN
fcis-1883	123	40	)	)	PUNCT
fcis-1883	123	41	.	.	PUNCT
fcis-1883	124	1	references	reference	NOUN
fcis-1883	124	2	[	[	X
fcis-1883	124	3	1	1	NUM
fcis-1883	124	4	]	]	X
fcis-1883	124	5	hausenloy	hausenloy	NOUN
fcis-1883	124	6	dj	dj	PROPN
fcis-1883	124	7	,	,	PUNCT
fcis-1883	124	8	yellon	yellon	PROPN
fcis-1883	124	9	dm	dm	PROPN
fcis-1883	124	10	.	.	PUNCT
fcis-1883	124	11	ischaemic	ischaemic	ADJ
fcis-1883	124	12	conditioning	conditioning	NOUN
fcis-1883	124	13	and	and	CCONJ
fcis-1883	124	14	reperfusion	reperfusion	NOUN
fcis-1883	124	15	injury	injury	NOUN
fcis-1883	124	16	.	.	PUNCT
fcis-1883	125	1	nat	nat	PROPN
fcis-1883	125	2	rev	rev	PROPN
fcis-1883	125	3	cardiol	cardiol	NOUN
fcis-1883	125	4	.	.	PUNCT
fcis-1883	126	1	2016;13(4):193	2016;13(4):193	NUM
fcis-1883	126	2	-	-	SYM
fcis-1883	126	3	209	209	NUM
fcis-1883	126	4	.	.	PUNCT
fcis-1883	127	1	doi:10.1038	doi:10.1038	NOUN
fcis-1883	127	2	/	/	SYM
fcis-1883	127	3	nrcardio.2016.5	nrcardio.2016.5	PROPN
fcis-1883	128	1	[	[	X
fcis-1883	128	2	2	2	NUM
fcis-1883	128	3	]	]	PUNCT
fcis-1883	128	4	turer	turer	NOUN
fcis-1883	128	5	at	at	ADP
fcis-1883	128	6	,	,	PUNCT
fcis-1883	128	7	hill	hill	PROPN
fcis-1883	128	8	ja	ja	PROPN
fcis-1883	128	9	.	.	PUNCT
fcis-1883	129	1	pathogenesis	pathogenesis	NOUN
fcis-1883	129	2	of	of	ADP
fcis-1883	129	3	myocardial	myocardial	ADJ
fcis-1883	129	4	ischemiareperfusion	ischemiareperfusion	NOUN
fcis-1883	129	5	injury	injury	NOUN
fcis-1883	129	6	and	and	CCONJ
fcis-1883	129	7	rationale	rationale	NOUN
fcis-1883	129	8	for	for	ADP
fcis-1883	129	9	therapy	therapy	NOUN
fcis-1883	129	10	.	.	PUNCT
fcis-1883	130	1	am	be	AUX
fcis-1883	130	2	j	j	PROPN
fcis-1883	130	3	cardiol	cardiol	NOUN
fcis-1883	130	4	.	.	PUNCT
fcis-1883	131	1	2010;106(3):360	2010;106(3):360	NUM
fcis-1883	131	2	-	-	PUNCT
fcis-1883	131	3	368	368	NUM
fcis-1883	131	4	.	.	PUNCT
fcis-1883	132	1	doi:10.1016	doi:10.1016	PROPN
fcis-1883	132	2	/	/	SYM
fcis-1883	132	3	j.amjcard.2010.03.032	j.amjcard.2010.03.032	PROPN
fcis-1883	133	1	[	[	X
fcis-1883	133	2	3	3	NUM
fcis-1883	133	3	]	]	X
fcis-1883	133	4	xiao	xiao	PROPN
fcis-1883	133	5	xh	xh	PROPN
fcis-1883	133	6	,	,	PUNCT
fcis-1883	133	7	allen	allen	PROPN
fcis-1883	133	8	dg	dg	PROPN
fcis-1883	133	9	.	.	PUNCT
fcis-1883	133	10	activity	activity	NOUN
fcis-1883	133	11	of	of	ADP
fcis-1883	133	12	the	the	DET
fcis-1883	133	13	na(+)/h(+	na(+)/h(+	NOUN
fcis-1883	133	14	)	)	PUNCT
fcis-1883	133	15	exchanger	exchanger	NOUN
fcis-1883	133	16	is	be	AUX
fcis-1883	133	17	critical	critical	ADJ
fcis-1883	133	18	to	to	ADP
fcis-1883	133	19	reperfusion	reperfusion	NOUN
fcis-1883	133	20	damage	damage	NOUN
fcis-1883	133	21	and	and	CCONJ
fcis-1883	133	22	preconditioning	precondition	VERB
fcis-1883	133	23	in	in	ADP
fcis-1883	133	24	the	the	DET
fcis-1883	133	25	isolated	isolated	ADJ
fcis-1883	133	26	rat	rat	NOUN
fcis-1883	133	27	heart	heart	NOUN
fcis-1883	133	28	.	.	PUNCT
fcis-1883	134	1	cardiovasc	cardiovasc	PROPN
fcis-1883	134	2	res	res	PROPN
fcis-1883	134	3	.	.	PUNCT
fcis-1883	135	1	2000;48(2):244	2000;48(2):244	PROPN
fcis-1883	135	2	-	-	PUNCT
fcis-1883	135	3	253	253	NUM
fcis-1883	135	4	.	.	PUNCT
fcis-1883	135	5	doi:10.1016	doi:10.1016	PROPN
fcis-1883	135	6	/	/	SYM
fcis-1883	135	7	s0008	s0008	PROPN
fcis-1883	135	8	-	-	PUNCT
fcis-1883	135	9	6363(00)00166	6363(00)00166	NUM
fcis-1883	135	10	-	-	PUNCT
fcis-1883	135	11	8	8	NUM
fcis-1883	136	1	[	[	SYM
fcis-1883	136	2	4	4	NUM
fcis-1883	136	3	]	]	X
fcis-1883	136	4	nserte	nserte	PROPN
fcis-1883	136	5	j	j	PROPN
fcis-1883	136	6	,	,	PUNCT
fcis-1883	136	7	barba	barba	PROPN
fcis-1883	136	8	i	i	PROPN
fcis-1883	136	9	,	,	PUNCT
fcis-1883	136	10	poncelas	poncelas	PROPN
fcis-1883	136	11	-	-	PUNCT
fcis-1883	136	12	nozal	nozal	PROPN
fcis-1883	136	13	m	m	PROPN
fcis-1883	136	14	,	,	PUNCT
fcis-1883	136	15	et	et	PROPN
fcis-1883	136	16	al	al	PROPN
fcis-1883	136	17	.	.	PROPN
fcis-1883	136	18	cgmp	cgmp	PROPN
fcis-1883	136	19	/	/	SYM
fcis-1883	136	20	pkg	pkg	NOUN
fcis-1883	136	21	pathway	pathway	NOUN
fcis-1883	136	22	mediates	mediate	VERB
fcis-1883	136	23	myocardial	myocardial	ADJ
fcis-1883	136	24	postconditioning	postconditione	VERB
fcis-1883	136	25	protection	protection	NOUN
fcis-1883	136	26	in	in	ADP
fcis-1883	136	27	rat	rat	NOUN
fcis-1883	136	28	hearts	heart	NOUN
fcis-1883	136	29	by	by	ADP
fcis-1883	136	30	delaying	delay	VERB
fcis-1883	136	31	normalization	normalization	NOUN
fcis-1883	136	32	of	of	ADP
fcis-1883	136	33	intracellular	intracellular	ADJ
fcis-1883	136	34	acidosis	acidosis	NOUN
fcis-1883	136	35	during	during	ADP
fcis-1883	136	36	reperfusion	reperfusion	NOUN
fcis-1883	136	37	.	.	PUNCT
fcis-1883	137	1	j	j	PROPN
fcis-1883	137	2	mol	mol	PROPN
fcis-1883	137	3	cell	cell	NOUN
fcis-1883	137	4	cardiol	cardiol	NOUN
fcis-1883	137	5	.	.	PUNCT
fcis-1883	138	1	2011;50(5):903	2011;50(5):903	NUM
fcis-1883	138	2	-	-	PUNCT
fcis-1883	138	3	909	909	NUM
fcis-1883	138	4	.	.	PUNCT
fcis-1883	139	1	doi:10.1016	doi:10.1016	PROPN
fcis-1883	139	2	/	/	SYM
fcis-1883	139	3	j.yjmcc.2011.02.013	j.yjmcc.2011.02.013	PROPN
fcis-1883	140	1	[	[	X
fcis-1883	140	2	5	5	NUM
fcis-1883	140	3	]	]	PUNCT
fcis-1883	140	4	ten	ten	NUM
fcis-1883	140	5	hove	hove	PROPN
fcis-1883	140	6	m	m	PROPN
fcis-1883	140	7	,	,	PUNCT
fcis-1883	140	8	van	van	PROPN
fcis-1883	140	9	emous	emous	ADJ
fcis-1883	140	10	jg	jg	PROPN
fcis-1883	140	11	,	,	PUNCT
fcis-1883	140	12	van	van	PROPN
fcis-1883	140	13	echteld	echteld	PROPN
fcis-1883	140	14	cj	cj	PROPN
fcis-1883	140	15	.	.	PUNCT
fcis-1883	141	1	na+	na+	NOUN
fcis-1883	141	2	overload	overload	NOUN
fcis-1883	141	3	during	during	ADP
fcis-1883	141	4	ischemia	ischemia	NOUN
fcis-1883	141	5	and	and	CCONJ
fcis-1883	141	6	reperfusion	reperfusion	NOUN
fcis-1883	141	7	in	in	ADP
fcis-1883	141	8	rat	rat	NOUN
fcis-1883	141	9	hearts	heart	NOUN
fcis-1883	141	10	:	:	PUNCT
fcis-1883	141	11	comparison	comparison	NOUN
fcis-1883	141	12	of	of	ADP
fcis-1883	141	13	the	the	DET
fcis-1883	141	14	na+/h+	na+/h+	ADJ
fcis-1883	141	15	exchange	exchange	NOUN
fcis-1883	141	16	blockers	blocker	NOUN
fcis-1883	141	17	eipa	eipa	ADJ
fcis-1883	141	18	,	,	PUNCT
fcis-1883	141	19	cariporide	cariporide	ADJ
fcis-1883	141	20	and	and	CCONJ
fcis-1883	141	21	eniporide	eniporide	ADJ
fcis-1883	141	22	.	.	PUNCT
fcis-1883	142	1	mol	mol	ADP
fcis-1883	142	2	cell	cell	NOUN
fcis-1883	142	3	biochem	biochem	PROPN
fcis-1883	142	4	.	.	PUNCT
fcis-1883	143	1	2003;250(1	2003;250(1	NUM
fcis-1883	143	2	-	-	SYM
fcis-1883	143	3	2):47	2):47	NUM
fcis-1883	143	4	-	-	SYM
fcis-1883	143	5	54	54	NUM
fcis-1883	143	6	.	.	PUNCT
fcis-1883	144	1	doi:10.1023	doi:10.1023	NOUN
fcis-1883	144	2	/	/	SYM
fcis-1883	144	3	a:1024985931797	a:1024985931797	X
fcis-1883	145	1	[	[	X
fcis-1883	145	2	6	6	NUM
fcis-1883	145	3	]	]	X
fcis-1883	145	4	garcia	garcia	PROPN
fcis-1883	145	5	-	-	PUNCT
fcis-1883	145	6	dorado	dorado	NOUN
fcis-1883	145	7	d	d	NOUN
fcis-1883	145	8	,	,	PUNCT
fcis-1883	145	9	ruiz	ruiz	NOUN
fcis-1883	145	10	-	-	PUNCT
fcis-1883	145	11	meana	meana	PROPN
fcis-1883	145	12	m	m	PROPN
fcis-1883	145	13	,	,	PUNCT
fcis-1883	145	14	inserte	inserte	PROPN
fcis-1883	145	15	j	j	PROPN
fcis-1883	145	16	,	,	PUNCT
fcis-1883	145	17	rodriguezsinovas	rodriguezsinovas	VERB
fcis-1883	145	18	a	a	DET
fcis-1883	145	19	,	,	PUNCT
fcis-1883	145	20	piper	piper	NOUN
fcis-1883	145	21	hm	hm	NOUN
fcis-1883	145	22	.	.	PUNCT
fcis-1883	145	23	calcium	calcium	NOUN
fcis-1883	145	24	-	-	PUNCT
fcis-1883	145	25	mediated	mediate	VERB
fcis-1883	145	26	cell	cell	NOUN
fcis-1883	145	27	death	death	NOUN
fcis-1883	145	28	during	during	ADP
fcis-1883	145	29	myocardial	myocardial	ADJ
fcis-1883	145	30	reperfusion	reperfusion	NOUN
fcis-1883	145	31	.	.	PUNCT
fcis-1883	146	1	cardiovasc	cardiovasc	PROPN
fcis-1883	146	2	res	res	PROPN
fcis-1883	146	3	.	.	PUNCT
fcis-1883	147	1	2012;94(2):168	2012;94(2):168	NOUN
fcis-1883	147	2	-	-	PUNCT
fcis-1883	147	3	180	180	NUM
fcis-1883	147	4	.	.	PUNCT
fcis-1883	147	5	doi:10.1093	doi:10.1093	NOUN
fcis-1883	147	6	/	/	SYM
fcis-1883	147	7	cvr	cvr	PROPN
fcis-1883	147	8	/	/	SYM
fcis-1883	147	9	cvs116	cvs116	PROPN
fcis-1883	148	1	[	[	X
fcis-1883	148	2	7	7	X
fcis-1883	148	3	]	]	PUNCT
fcis-1883	148	4	maddaford	maddaford	NOUN
fcis-1883	148	5	tg	tg	PROPN
fcis-1883	148	6	,	,	PUNCT
fcis-1883	148	7	dibrov	dibrov	NOUN
fcis-1883	148	8	e	e	NOUN
fcis-1883	148	9	,	,	PUNCT
fcis-1883	148	10	hurtado	hurtado	PROPN
fcis-1883	148	11	c	c	PROPN
fcis-1883	148	12	,	,	PUNCT
fcis-1883	148	13	pierce	pierce	PROPN
fcis-1883	148	14	gn	gn	PROPN
fcis-1883	148	15	.	.	PROPN
fcis-1883	148	16	reduced	reduce	VERB
fcis-1883	148	17	expression	expression	NOUN
fcis-1883	148	18	of	of	ADP
fcis-1883	148	19	the	the	DET
fcis-1883	148	20	na+/ca2	na+/ca2	NOUN
fcis-1883	148	21	+	+	NOUN
fcis-1883	148	22	exchanger	exchanger	NOUN
fcis-1883	148	23	in	in	ADP
fcis-1883	148	24	adult	adult	NOUN
fcis-1883	148	25	cardiomyocytes	cardiomyocyte	NOUN
fcis-1883	148	26	via	via	ADP
fcis-1883	148	27	adenovirally	adenovirally	ADV
fcis-1883	148	28	delivered	deliver	VERB
fcis-1883	148	29	shrna	shrna	NOUN
fcis-1883	148	30	results	result	NOUN
fcis-1883	148	31	in	in	ADP
fcis-1883	148	32	resistance	resistance	NOUN
fcis-1883	148	33	to	to	ADP
fcis-1883	148	34	simulated	simulate	VERB
fcis-1883	148	35	ischemic	ischemic	ADJ
fcis-1883	148	36	injury	injury	NOUN
fcis-1883	148	37	.	.	PUNCT
fcis-1883	149	1	am	be	AUX
fcis-1883	149	2	j	j	PROPN
fcis-1883	149	3	physiol	physiol	PROPN
fcis-1883	149	4	heart	heart	PROPN
fcis-1883	149	5	circ	circ	PROPN
fcis-1883	149	6	physiol	physiol	PROPN
fcis-1883	149	7	.	.	PUNCT
fcis-1883	150	1	2010;298(2):h360	2010;298(2):h360	NUM
fcis-1883	150	2	-	-	SYM
fcis-1883	150	3	h366	h366	PROPN
fcis-1883	150	4	.	.	PUNCT
fcis-1883	150	5	doi:10.1152	doi:10.1152	NOUN
fcis-1883	150	6	/	/	SYM
fcis-1883	150	7	ajpheart.00932.2009	ajpheart.00932.2009	NOUN
fcis-1883	150	8	[	[	X
fcis-1883	150	9	8	8	NUM
fcis-1883	150	10	]	]	X
fcis-1883	150	11	talukder	talukder	NOUN
fcis-1883	150	12	ma	ma	PROPN
fcis-1883	150	13	,	,	PUNCT
fcis-1883	150	14	kalyanasundaram	kalyanasundaram	PROPN
fcis-1883	150	15	a	a	NOUN
fcis-1883	150	16	,	,	PUNCT
fcis-1883	150	17	zuo	zuo	PROPN
fcis-1883	150	18	l	l	PROPN
fcis-1883	150	19	,	,	PUNCT
fcis-1883	150	20	et	et	PROPN
fcis-1883	150	21	al	al	PROPN
fcis-1883	150	22	.	.	PROPN
fcis-1883	150	23	is	be	AUX
fcis-1883	150	24	reduced	reduce	VERB
fcis-1883	150	25	serca2a	serca2a	NOUN
fcis-1883	150	26	expression	expression	NOUN
fcis-1883	150	27	detrimental	detrimental	ADJ
fcis-1883	150	28	or	or	CCONJ
fcis-1883	150	29	beneficial	beneficial	ADJ
fcis-1883	150	30	to	to	ADP
fcis-1883	150	31	postischemic	postischemic	ADJ
fcis-1883	150	32	cardiac	cardiac	ADJ
fcis-1883	150	33	function	function	NOUN
fcis-1883	150	34	and	and	CCONJ
fcis-1883	150	35	injury	injury	NOUN
fcis-1883	150	36	?	?	PUNCT
fcis-1883	151	1	evidence	evidence	NOUN
fcis-1883	151	2	from	from	ADP
fcis-1883	151	3	heterozygous	heterozygous	ADJ
fcis-1883	151	4	serca2a	serca2a	NOUN
fcis-1883	151	5	knockout	knockout	NOUN
fcis-1883	151	6	mice	mouse	NOUN
fcis-1883	151	7	.	.	PUNCT
fcis-1883	152	1	am	be	AUX
fcis-1883	152	2	j	j	PROPN
fcis-1883	152	3	physiol	physiol	PROPN
fcis-1883	152	4	heart	heart	PROPN
fcis-1883	152	5	circ	circ	PROPN
fcis-1883	152	6	physiol	physiol	PROPN
fcis-1883	152	7	.	.	PUNCT
fcis-1883	153	1	2008;294(3):h1426	2008;294(3):h1426	NUM
fcis-1883	153	2	-	-	PUNCT
fcis-1883	153	3	h1434	h1434	NOUN
fcis-1883	153	4	.	.	PUNCT
fcis-1883	153	5	doi:10.1152	doi:10.1152	NOUN
fcis-1883	153	6	/	/	SYM
fcis-1883	153	7	ajpheart.01016.2007	ajpheart.01016.2007	PROPN
fcis-1883	154	1	[	[	X
fcis-1883	154	2	9	9	NUM
fcis-1883	154	3	]	]	X
fcis-1883	154	4	nichols	nichols	PROPN
fcis-1883	154	5	cg	cg	PROPN
fcis-1883	154	6	,	,	PUNCT
fcis-1883	154	7	lederer	lederer	PROPN
fcis-1883	154	8	wj	wj	PROPN
fcis-1883	154	9	.	.	PUNCT
fcis-1883	155	1	the	the	DET
fcis-1883	155	2	role	role	NOUN
fcis-1883	155	3	of	of	ADP
fcis-1883	155	4	atp	atp	PROPN
fcis-1883	155	5	in	in	ADP
fcis-1883	155	6	energydeprivation	energydeprivation	NOUN
fcis-1883	155	7	contractures	contracture	NOUN
fcis-1883	155	8	in	in	ADP
fcis-1883	155	9	unloaded	unload	VERB
fcis-1883	155	10	rat	rat	NOUN
fcis-1883	155	11	ventricular	ventricular	ADJ
fcis-1883	155	12	myocytes	myocyte	NOUN
fcis-1883	155	13	.	.	PUNCT
fcis-1883	156	1	can	can	AUX
fcis-1883	156	2	j	j	PROPN
fcis-1883	156	3	physiol	physiol	PROPN
fcis-1883	156	4	pharmacol	pharmacol	PROPN
fcis-1883	156	5	.	.	PUNCT
fcis-1883	157	1	1990;68(2):183	1990;68(2):183	NUM
fcis-1883	157	2	-	-	SYM
fcis-1883	157	3	194	194	NUM
fcis-1883	157	4	.	.	PUNCT
fcis-1883	158	1	doi:10.1139	doi:10.1139	NOUN
fcis-1883	158	2	/	/	SYM
fcis-1883	158	3	y90	y90	PROPN
fcis-1883	158	4	-	-	PUNCT
fcis-1883	158	5	029	029	NUM
fcis-1883	159	1	[	[	X
fcis-1883	159	2	10	10	NUM
fcis-1883	159	3	]	]	X
fcis-1883	160	1	[	[	X
fcis-1883	160	2	10	10	NUM
fcis-1883	160	3	]	]	X
fcis-1883	160	4	rizzuto	rizzuto	PROPN
fcis-1883	160	5	r	r	PROPN
fcis-1883	160	6	,	,	PUNCT
fcis-1883	160	7	de	de	X
fcis-1883	160	8	stefani	stefani	X
fcis-1883	160	9	d	d	PROPN
fcis-1883	160	10	,	,	PUNCT
fcis-1883	160	11	raffaello	raffaello	PROPN
fcis-1883	160	12	a	a	PROPN
fcis-1883	160	13	,	,	PUNCT
fcis-1883	160	14	mammucari	mammucari	PROPN
fcis-1883	160	15	c.	c.	PROPN
fcis-1883	160	16	mitochondria	mitochondria	PROPN
fcis-1883	160	17	as	as	ADP
fcis-1883	160	18	sensors	sensor	NOUN
fcis-1883	160	19	and	and	CCONJ
fcis-1883	160	20	regulators	regulator	NOUN
fcis-1883	160	21	of	of	ADP
fcis-1883	160	22	calcium	calcium	NOUN
fcis-1883	160	23	signalling	signal	VERB
fcis-1883	160	24	.	.	PUNCT
fcis-1883	161	1	nat	nat	PROPN
fcis-1883	161	2	rev	rev	VERB
fcis-1883	161	3	mol	mol	ADP
fcis-1883	161	4	cell	cell	NOUN
fcis-1883	161	5	biol	biol	NOUN
fcis-1883	161	6	.	.	PUNCT
fcis-1883	162	1	2012;13(9):566	2012;13(9):566	NUM
fcis-1883	162	2	-	-	SYM
fcis-1883	162	3	578	578	NUM
fcis-1883	162	4	.	.	PUNCT
fcis-1883	163	1	doi:10.1038	doi:10.1038	NOUN
fcis-1883	163	2	/	/	SYM
fcis-1883	163	3	nrm3412	nrm3412	NOUN
fcis-1883	164	1	[	[	X
fcis-1883	164	2	11	11	NUM
fcis-1883	164	3	]	]	PUNCT
fcis-1883	164	4	arreola	arreola	PROPN
fcis-1883	164	5	j	j	PROPN
fcis-1883	164	6	,	,	PUNCT
fcis-1883	164	7	dirksen	dirksen	PROPN
fcis-1883	164	8	rt	rt	PROPN
fcis-1883	164	9	,	,	PUNCT
fcis-1883	164	10	shieh	shieh	PROPN
fcis-1883	164	11	rc	rc	PROPN
fcis-1883	164	12	,	,	PUNCT
fcis-1883	164	13	williford	williford	PROPN
fcis-1883	164	14	dj	dj	PROPN
fcis-1883	164	15	,	,	PUNCT
fcis-1883	164	16	sheu	sheu	PROPN
fcis-1883	164	17	ss	ss	PROPN
fcis-1883	164	18	.	.	PUNCT
fcis-1883	165	1	ca2	ca2	PROPN
fcis-1883	165	2	+	+	PROPN
fcis-1883	165	3	current	current	ADJ
fcis-1883	165	4	and	and	CCONJ
fcis-1883	165	5	ca2	ca2	PROPN
fcis-1883	165	6	+	+	PROPN
fcis-1883	165	7	transients	transient	NOUN
fcis-1883	165	8	under	under	ADP
fcis-1883	165	9	action	action	NOUN
fcis-1883	165	10	potential	potential	ADJ
fcis-1883	165	11	clamp	clamp	NOUN
fcis-1883	165	12	in	in	ADP
fcis-1883	165	13	guinea	guinea	NOUN
fcis-1883	165	14	pig	pig	NOUN
fcis-1883	165	15	ventricular	ventricular	ADJ
fcis-1883	165	16	myocytes	myocyte	NOUN
fcis-1883	165	17	.	.	PUNCT
fcis-1883	166	1	am	be	AUX
fcis-1883	166	2	j	j	PROPN
fcis-1883	166	3	physiol	physiol	PROPN
fcis-1883	166	4	.	.	PUNCT
fcis-1883	167	1	1991;261(2	1991;261(2	NUM
fcis-1883	167	2	pt	pt	PROPN
fcis-1883	167	3	1):c393	1):c393	NUM
fcis-1883	167	4	-	-	PUNCT
fcis-1883	167	5	c397	c397	PROPN
fcis-1883	167	6	.	.	PUNCT
fcis-1883	167	7	doi:10.1152	doi:10.1152	NOUN
fcis-1883	167	8	/	/	SYM
fcis-1883	167	9	ajpcell.1991.261.2.c393	ajpcell.1991.261.2.c393	PROPN
fcis-1883	168	1	[	[	X
fcis-1883	168	2	12	12	NUM
fcis-1883	168	3	]	]	PUNCT
fcis-1883	168	4	gonzález	gonzález	PROPN
fcis-1883	168	5	g	g	PROPN
fcis-1883	168	6	,	,	PUNCT
fcis-1883	168	7	zaldívar	zaldívar	PROPN
fcis-1883	168	8	d	d	PROPN
fcis-1883	168	9	,	,	PUNCT
fcis-1883	168	10	carrillo	carrillo	PROPN
fcis-1883	168	11	e	e	PROPN
fcis-1883	168	12	,	,	PUNCT
fcis-1883	168	13	hernández	hernández	PROPN
fcis-1883	168	14	a	a	PRON
fcis-1883	168	15	,	,	PUNCT
fcis-1883	168	16	garcía	garcía	PROPN
fcis-1883	168	17	m	m	PROPN
fcis-1883	168	18	,	,	PUNCT
fcis-1883	168	19	sánchez	sánchez	PROPN
fcis-1883	168	20	j.	j.	PROPN
fcis-1883	168	21	pharmacological	pharmacological	PROPN
fcis-1883	168	22	preconditioning	precondition	VERB
fcis-1883	168	23	by	by	ADP
fcis-1883	168	24	diazoxide	diazoxide	NOUN
fcis-1883	168	25	downregulates	downregulate	VERB
fcis-1883	168	26	cardiac	cardiac	ADJ
fcis-1883	168	27	l	l	NOUN
fcis-1883	168	28	-	-	PUNCT
fcis-1883	168	29	type	type	NOUN
fcis-1883	168	30	ca(2	ca(2	NOUN
fcis-1883	168	31	+	+	NOUN
fcis-1883	168	32	)	)	PUNCT
fcis-1883	168	33	channels	channel	NOUN
fcis-1883	168	34	.	.	PUNCT
fcis-1883	169	1	br	br	PROPN
fcis-1883	169	2	j	j	PROPN
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fcis-1883	169	4	.	.	PUNCT
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fcis-1883	170	2	-	-	SYM
fcis-1883	170	3	1185	1185	NUM
fcis-1883	170	4	.	.	PUNCT
fcis-1883	171	1	doi:10.1111	doi:10.1111	NOUN
fcis-1883	171	2	/	/	SYM
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fcis-1883	172	1	[	[	SYM
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fcis-1883	172	3	]	]	SYM
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fcis-1883	172	5	ma	ma	PROPN
fcis-1883	172	6	,	,	PUNCT
fcis-1883	172	7	zweier	zweier	NOUN
fcis-1883	172	8	jl	jl	NOUN
fcis-1883	172	9	,	,	PUNCT
fcis-1883	172	10	periasamy	periasamy	ADJ
fcis-1883	172	11	m.	m.	NOUN
fcis-1883	172	12	targeting	target	VERB
fcis-1883	172	13	calcium	calcium	NOUN
fcis-1883	172	14	transport	transport	NOUN
fcis-1883	172	15	in	in	ADP
fcis-1883	172	16	ischaemic	ischaemic	ADJ
fcis-1883	172	17	heart	heart	NOUN
fcis-1883	172	18	disease	disease	NOUN
fcis-1883	172	19	.	.	PUNCT
fcis-1883	173	1	cardiovasc	cardiovasc	PROPN
fcis-1883	173	2	res	res	PROPN
fcis-1883	173	3	.	.	PUNCT
fcis-1883	174	1	2009;84(3):345	2009;84(3):345	NUM
fcis-1883	174	2	-	-	PUNCT
fcis-1883	174	3	352	352	NUM
fcis-1883	174	4	.	.	PUNCT
fcis-1883	174	5	doi:10.1093	doi:10.1093	NOUN
fcis-1883	174	6	/	/	SYM
fcis-1883	174	7	cvr	cvr	PROPN
fcis-1883	174	8	/	/	SYM
fcis-1883	174	9	cvp264	cvp264	PROPN
fcis-1883	174	10	[	[	X
fcis-1883	174	11	14	14	NUM
fcis-1883	174	12	]	]	X
fcis-1883	174	13	du	du	PROPN
fcis-1883	174	14	toit	toit	PROPN
fcis-1883	174	15	ef	ef	PROPN
fcis-1883	174	16	,	,	PUNCT
fcis-1883	174	17	opie	opie	PROPN
fcis-1883	174	18	lh	lh	PROPN
fcis-1883	174	19	.	.	PUNCT
fcis-1883	175	1	modulation	modulation	NOUN
fcis-1883	175	2	of	of	ADP
fcis-1883	175	3	severity	severity	NOUN
fcis-1883	175	4	of	of	ADP
fcis-1883	175	5	reperfusion	reperfusion	NOUN
fcis-1883	175	6	stunning	stunning	ADJ
fcis-1883	175	7	in	in	ADP
fcis-1883	175	8	the	the	DET
fcis-1883	175	9	isolated	isolated	ADJ
fcis-1883	175	10	rat	rat	NOUN
fcis-1883	175	11	heart	heart	NOUN
fcis-1883	175	12	by	by	ADP
fcis-1883	175	13	agents	agent	NOUN
fcis-1883	175	14	altering	alter	VERB
fcis-1883	175	15	calcium	calcium	NOUN
fcis-1883	175	16	flux	flux	NOUN
fcis-1883	175	17	at	at	ADP
fcis-1883	175	18	onset	onset	NOUN
fcis-1883	175	19	of	of	ADP
fcis-1883	175	20	reperfusion	reperfusion	NOUN
fcis-1883	175	21	.	.	PUNCT
fcis-1883	176	1	circ	circ	PROPN
fcis-1883	176	2	res	res	PROPN
fcis-1883	176	3	.	.	PUNCT
fcis-1883	177	1	1992;70(5):960	1992;70(5):960	NUM
fcis-1883	177	2	-	-	PUNCT
fcis-1883	177	3	967	967	NUM
fcis-1883	177	4	.	.	PUNCT
fcis-1883	178	1	doi:10.1161/01.res.70.5.960	doi:10.1161/01.res.70.5.960	PROPN
fcis-1883	178	2	[	[	X
fcis-1883	178	3	15	15	NUM
fcis-1883	178	4	]	]	PUNCT
fcis-1883	178	5	anderson	anderson	PROPN
fcis-1883	178	6	me	me	PROPN
fcis-1883	178	7	.	.	PUNCT
fcis-1883	179	1	calmodulin	calmodulin	PROPN
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fcis-1883	179	3	signaling	signal	VERB
fcis-1883	179	4	in	in	ADP
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fcis-1883	179	6	:	:	PUNCT
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fcis-1883	179	9	candidate	candidate	NOUN
fcis-1883	179	10	target	target	NOUN
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fcis-1883	179	12	therapy	therapy	NOUN
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fcis-1883	179	14	myocardial	myocardial	ADJ
fcis-1883	179	15	dysfunction	dysfunction	NOUN
fcis-1883	179	16	and	and	CCONJ
fcis-1883	179	17	arrhythmias	arrhythmia	NOUN
fcis-1883	179	18	.	.	PUNCT
fcis-1883	180	1	pharmacol	pharmacol	NOUN
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fcis-1883	181	2	-	-	SYM
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fcis-1883	181	4	.	.	PUNCT
fcis-1883	182	1	doi:10.1016	doi:10.1016	PROPN
fcis-1883	182	2	/	/	SYM
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fcis-1883	183	5	me	me	PROPN
fcis-1883	183	6	,	,	PUNCT
fcis-1883	183	7	brown	brown	PROPN
fcis-1883	183	8	jh	jh	PROPN
fcis-1883	183	9	,	,	PUNCT
fcis-1883	183	10	bers	ber	VERB
fcis-1883	183	11	dm	dm	PROPN
fcis-1883	183	12	.	.	PUNCT
fcis-1883	184	1	camkii	camkii	PROPN
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fcis-1883	184	6	heart	heart	NOUN
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fcis-1883	184	8	.	.	PUNCT
fcis-1883	185	1	j	j	PROPN
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fcis-1883	185	5	.	.	PUNCT
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fcis-1883	186	2	-	-	PUNCT
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fcis-1883	186	4	.	.	PUNCT
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fcis-1883	188	13	korthuis	korthuis	PROPN
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fcis-1883	188	15	.	.	PROPN
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fcis-1883	188	19	.	.	PUNCT
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fcis-1883	189	2	physiol	physiol	PROPN
fcis-1883	189	3	.	.	PUNCT
fcis-1883	190	1	2016;7(1):113	2016;7(1):113	NUM
fcis-1883	190	2	-	-	SYM
fcis-1883	190	3	170	170	NUM
fcis-1883	190	4	.	.	PUNCT
fcis-1883	191	1	published	publish	VERB
fcis-1883	191	2	2016	2016	NUM
fcis-1883	191	3	dec	dec	PROPN
fcis-1883	191	4	6	6	NUM
fcis-1883	191	5	.	.	PUNCT
fcis-1883	191	6	doi:10.1002	doi:10.1002	NOUN
fcis-1883	191	7	/	/	SYM
fcis-1883	191	8	cphy.c160006	cphy.c160006	NOUN
fcis-1883	192	1	[	[	X
fcis-1883	192	2	18	18	NUM
fcis-1883	192	3	]	]	X
fcis-1883	192	4	williams	williams	PROPN
fcis-1883	192	5	gs	gs	PROPN
fcis-1883	192	6	,	,	PUNCT
fcis-1883	192	7	boyman	boyman	NOUN
fcis-1883	192	8	l	l	PROPN
fcis-1883	192	9	,	,	PUNCT
fcis-1883	192	10	lederer	lederer	PROPN
fcis-1883	192	11	wj	wj	PROPN
fcis-1883	192	12	.	.	PUNCT
fcis-1883	193	1	mitochondrial	mitochondrial	ADJ
fcis-1883	193	2	calcium	calcium	NOUN
fcis-1883	193	3	and	and	CCONJ
fcis-1883	193	4	the	the	DET
fcis-1883	193	5	regulation	regulation	NOUN
fcis-1883	193	6	of	of	ADP
fcis-1883	193	7	metabolism	metabolism	NOUN
fcis-1883	193	8	in	in	ADP
fcis-1883	193	9	the	the	DET
fcis-1883	193	10	heart	heart	NOUN
fcis-1883	193	11	.	.	PUNCT
fcis-1883	194	1	j	j	PROPN
fcis-1883	194	2	mol	mol	PROPN
fcis-1883	194	3	cell	cell	NOUN
fcis-1883	194	4	cardiol	cardiol	NOUN
fcis-1883	194	5	.	.	PUNCT
fcis-1883	195	1	2015;78:35	2015;78:35	NUM
fcis-1883	195	2	-	-	SYM
fcis-1883	195	3	45	45	NUM
fcis-1883	195	4	.	.	PUNCT
fcis-1883	195	5	doi:10.1016	doi:10.1016	PROPN
fcis-1883	195	6	/	/	SYM
fcis-1883	195	7	j.yjmcc.2014.10.019	j.yjmcc.2014.10.019	PROPN
fcis-1883	196	1	[	[	X
fcis-1883	196	2	19	19	NUM
fcis-1883	196	3	]	]	PUNCT
fcis-1883	196	4	heusch	heusch	PROPN
fcis-1883	196	5	g	g	PROPN
fcis-1883	196	6	,	,	PUNCT
fcis-1883	196	7	boengler	boengler	NOUN
fcis-1883	196	8	k	k	PROPN
fcis-1883	196	9	,	,	PUNCT
fcis-1883	196	10	schulz	schulz	PROPN
fcis-1883	196	11	r.	r.	PROPN
fcis-1883	196	12	inhibition	inhibition	NOUN
fcis-1883	196	13	of	of	ADP
fcis-1883	196	14	mitochondrial	mitochondrial	ADJ
fcis-1883	196	15	permeability	permeability	NOUN
fcis-1883	196	16	transition	transition	NOUN
fcis-1883	196	17	pore	pore	ADJ
fcis-1883	196	18	opening	opening	NOUN
fcis-1883	196	19	:	:	PUNCT
fcis-1883	196	20	the	the	DET
fcis-1883	196	21	holy	holy	ADJ
fcis-1883	196	22	grail	grail	NOUN
fcis-1883	196	23	of	of	ADP
fcis-1883	196	24	cardioprotection	cardioprotection	NOUN
fcis-1883	196	25	.	.	PUNCT
fcis-1883	197	1	basic	basic	ADJ
fcis-1883	197	2	res	re	NOUN
fcis-1883	197	3	cardiol	cardiol	NOUN
fcis-1883	197	4	.	.	PUNCT
fcis-1883	198	1	2010;105(2):151	2010;105(2):151	NUM
fcis-1883	198	2	-	-	SYM
fcis-1883	198	3	154	154	NUM
fcis-1883	198	4	.	.	PUNCT
fcis-1883	199	1	doi:10.1007	doi:10.1007	PROPN
fcis-1883	199	2	/	/	SYM
fcis-1883	199	3	s00395	s00395	PROPN
fcis-1883	199	4	-	-	PUNCT
fcis-1883	199	5	009	009	NUM
fcis-1883	199	6	-	-	PUNCT
fcis-1883	199	7	0080	0080	NUM
fcis-1883	199	8	-	-	SYM
fcis-1883	199	9	9	9	NUM
fcis-1883	199	10	[	[	SYM
fcis-1883	199	11	20	20	NUM
fcis-1883	199	12	]	]	X
fcis-1883	199	13	baines	baine	NOUN
fcis-1883	199	14	cp	cp	PROPN
fcis-1883	199	15	,	,	PUNCT
fcis-1883	199	16	kaiser	kaiser	PROPN
fcis-1883	199	17	ra	ra	PROPN
fcis-1883	199	18	,	,	PUNCT
fcis-1883	199	19	purcell	purcell	PROPN
fcis-1883	199	20	nh	nh	PROPN
fcis-1883	199	21	,	,	PUNCT
fcis-1883	199	22	et	et	PROPN
fcis-1883	199	23	al	al	PROPN
fcis-1883	199	24	.	.	PUNCT
fcis-1883	199	25	loss	loss	NOUN
fcis-1883	199	26	of	of	ADP
fcis-1883	199	27	cyclophilin	cyclophilin	PROPN
fcis-1883	199	28	d	d	PROPN
fcis-1883	199	29	reveals	reveal	VERB
fcis-1883	199	30	a	a	DET
fcis-1883	199	31	critical	critical	ADJ
fcis-1883	199	32	role	role	NOUN
fcis-1883	199	33	for	for	ADP
fcis-1883	199	34	mitochondrial	mitochondrial	ADJ
fcis-1883	199	35	permeability	permeability	NOUN
fcis-1883	199	36	transition	transition	NOUN
fcis-1883	199	37	in	in	ADP
fcis-1883	199	38	cell	cell	NOUN
fcis-1883	199	39	death	death	NOUN
fcis-1883	199	40	.	.	PUNCT
fcis-1883	200	1	nature	nature	NOUN
fcis-1883	200	2	.	.	PUNCT
fcis-1883	201	1	2005;434(7033):658	2005;434(7033):658	NUM
fcis-1883	201	2	-	-	SYM
fcis-1883	201	3	662	662	NUM
fcis-1883	201	4	.	.	PUNCT
fcis-1883	201	5	doi:10.1038	doi:10.1038	NOUN
fcis-1883	201	6	/	/	SYM
fcis-1883	201	7	nature03434	nature03434	PROPN
fcis-1883	202	1	[	[	X
fcis-1883	202	2	21	21	NUM
fcis-1883	202	3	]	]	X
fcis-1883	202	4	ruiz	ruiz	NOUN
fcis-1883	202	5	-	-	PUNCT
fcis-1883	202	6	meana	meana	PROPN
fcis-1883	202	7	m	m	PROPN
fcis-1883	202	8	,	,	PUNCT
fcis-1883	202	9	inserte	inserte	PROPN
fcis-1883	202	10	j	j	PROPN
fcis-1883	202	11	,	,	PUNCT
fcis-1883	202	12	fernandez	fernandez	PROPN
fcis-1883	202	13	-	-	PUNCT
fcis-1883	202	14	sanz	sanz	PROPN
fcis-1883	202	15	c	c	PROPN
fcis-1883	202	16	,	,	PUNCT
fcis-1883	202	17	et	et	PROPN
fcis-1883	202	18	al	al	PROPN
fcis-1883	202	19	.	.	PUNCT
fcis-1883	203	1	the	the	DET
fcis-1883	203	2	role	role	NOUN
fcis-1883	203	3	of	of	ADP
fcis-1883	203	4	mitochondrial	mitochondrial	ADJ
fcis-1883	203	5	permeability	permeability	NOUN
fcis-1883	203	6	transition	transition	NOUN
fcis-1883	203	7	in	in	ADP
fcis-1883	203	8	reperfusion	reperfusion	NOUN
fcis-1883	203	9	-	-	PUNCT
fcis-1883	203	10	induced	induce	VERB
fcis-1883	203	11	cardiomyocyte	cardiomyocyte	NOUN
fcis-1883	203	12	death	death	NOUN
fcis-1883	203	13	depends	depend	VERB
fcis-1883	203	14	on	on	ADP
fcis-1883	203	15	the	the	DET
fcis-1883	203	16	duration	duration	NOUN
fcis-1883	203	17	of	of	ADP
fcis-1883	203	18	ischemia	ischemia	NOUN
fcis-1883	203	19	.	.	PUNCT
fcis-1883	204	1	basic	basic	ADJ
fcis-1883	204	2	res	re	NOUN
fcis-1883	204	3	cardiol	cardiol	NOUN
fcis-1883	204	4	.	.	PUNCT
fcis-1883	205	1	2011;106(6):1259	2011;106(6):1259	NUM
fcis-1883	205	2	-	-	SYM
fcis-1883	205	3	1268	1268	NUM
fcis-1883	205	4	.	.	PUNCT
fcis-1883	206	1	doi:10.1007	doi:10.1007	PROPN
fcis-1883	206	2	/	/	SYM
fcis-1883	206	3	s00395	s00395	PROPN
fcis-1883	206	4	-	-	PUNCT
fcis-1883	206	5	011	011	NUM
fcis-1883	206	6	-	-	PUNCT
fcis-1883	206	7	0225	0225	NUM
fcis-1883	206	8	-	-	SYM
fcis-1883	206	9	5	5	NUM
fcis-1883	206	10	[	[	SYM
fcis-1883	206	11	22	22	NUM
fcis-1883	206	12	]	]	X
fcis-1883	206	13	piper	piper	NOUN
fcis-1883	206	14	hm	hm	PROPN
fcis-1883	206	15	,	,	PUNCT
fcis-1883	206	16	abdallah	abdallah	PROPN
fcis-1883	206	17	y	y	PROPN
fcis-1883	206	18	,	,	PUNCT
fcis-1883	206	19	schäfer	schäfer	NOUN
fcis-1883	206	20	c.	c.	NOUN
fcis-1883	206	21	the	the	DET
fcis-1883	206	22	first	first	ADJ
fcis-1883	206	23	minutes	minute	NOUN
fcis-1883	206	24	of	of	ADP
fcis-1883	206	25	reperfusion	reperfusion	NOUN
fcis-1883	206	26	:	:	PUNCT
fcis-1883	206	27	a	a	DET
fcis-1883	206	28	window	window	NOUN
fcis-1883	206	29	of	of	ADP
fcis-1883	206	30	opportunity	opportunity	NOUN
fcis-1883	206	31	for	for	ADP
fcis-1883	206	32	cardioprotection	cardioprotection	NOUN
fcis-1883	206	33	.	.	PUNCT
fcis-1883	207	1	cardiovasc	cardiovasc	PROPN
fcis-1883	207	2	res	re	NOUN
fcis-1883	207	3	.	.	PUNCT
fcis-1883	208	1	2004;61(3):365	2004;61(3):365	NUM
fcis-1883	208	2	-	-	SYM
fcis-1883	208	3	371	371	NUM
fcis-1883	208	4	.	.	PUNCT
fcis-1883	208	5	doi:10.1016	doi:10.1016	PROPN
fcis-1883	208	6	/	/	SYM
fcis-1883	208	7	j.cardiores.2003.12.012	j.cardiores.2003.12.012	PROPN
fcis-1883	209	1	[	[	X
fcis-1883	209	2	23	23	NUM
fcis-1883	209	3	]	]	X
fcis-1883	209	4	ray	ray	PROPN
fcis-1883	209	5	m	m	PROPN
fcis-1883	209	6	,	,	PUNCT
fcis-1883	209	7	srivastava	srivastava	PROPN
fcis-1883	209	8	s	s	PROPN
fcis-1883	209	9	,	,	PUNCT
fcis-1883	209	10	maitra	maitra	PROPN
fcis-1883	209	11	sc	sc	PROPN
fcis-1883	209	12	,	,	PUNCT
fcis-1883	209	13	dubey	dubey	PROPN
fcis-1883	209	14	mp	mp	PROPN
fcis-1883	209	15	.	.	PUNCT
fcis-1883	210	1	the	the	DET
fcis-1883	210	2	hamster	hamster	PROPN
fcis-1883	210	3	heart	heart	NOUN
fcis-1883	210	4	is	be	AUX
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fcis-1883	210	6	to	to	ADP
fcis-1883	210	7	calcium	calcium	NOUN
fcis-1883	210	8	paradox	paradox	NOUN
fcis-1883	210	9	.	.	PUNCT
fcis-1883	211	1	pharmacol	pharmacol	NOUN
fcis-1883	211	2	res	re	NOUN
fcis-1883	211	3	.	.	PUNCT
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fcis-1883	212	2	-	-	SYM
fcis-1883	212	3	481	481	NUM
fcis-1883	212	4	.	.	PUNCT
fcis-1883	213	1	doi:10.1006	doi:10.1006	PROPN
fcis-1883	213	2	/	/	SYM
fcis-1883	214	1	phrs.1999.0607	phrs.1999.0607	PROPN
fcis-1883	214	2	[	[	X
fcis-1883	214	3	24	24	NUM
fcis-1883	214	4	]	]	X
fcis-1883	214	5	yoshikawa	yoshikawa	PROPN
fcis-1883	214	6	y	y	PROPN
fcis-1883	214	7	,	,	PUNCT
fcis-1883	214	8	hagihara	hagihara	PROPN
fcis-1883	214	9	h	h	NOUN
fcis-1883	214	10	,	,	PUNCT
fcis-1883	214	11	ohga	ohga	VERB
fcis-1883	214	12	y	y	PROPN
fcis-1883	214	13	,	,	PUNCT
fcis-1883	214	14	et	et	PROPN
fcis-1883	214	15	al	al	PROPN
fcis-1883	214	16	.	.	PROPN
fcis-1883	214	17	calpain	calpain	PROPN
fcis-1883	214	18	inhibitor-1	inhibitor-1	NUM
fcis-1883	214	19	protects	protect	VERB
fcis-1883	214	20	the	the	DET
fcis-1883	214	21	rat	rat	NOUN
fcis-1883	214	22	heart	heart	NOUN
fcis-1883	214	23	from	from	ADP
fcis-1883	214	24	ischemia	ischemia	NOUN
fcis-1883	214	25	-	-	PUNCT
fcis-1883	214	26	reperfusion	reperfusion	NOUN
fcis-1883	214	27	injury	injury	NOUN
fcis-1883	214	28	:	:	PUNCT
fcis-1883	214	29	analysis	analysis	NOUN
fcis-1883	214	30	by	by	ADP
fcis-1883	214	31	mechanical	mechanical	ADJ
fcis-1883	214	32	work	work	NOUN
fcis-1883	214	33	and	and	CCONJ
fcis-1883	214	34	energetics	energetic	NOUN
fcis-1883	214	35	.	.	PUNCT
fcis-1883	215	1	am	be	AUX
fcis-1883	215	2	j	j	PROPN
fcis-1883	215	3	physiol	physiol	PROPN
fcis-1883	215	4	heart	heart	PROPN
fcis-1883	215	5	circ	circ	PROPN
fcis-1883	215	6	physiol	physiol	PROPN
fcis-1883	215	7	.	.	PUNCT
fcis-1883	216	1	2005;288(4):h1690	2005;288(4):h1690	NUM
fcis-1883	216	2	-	-	PUNCT
fcis-1883	216	3	h1698	h1698	NOUN
fcis-1883	216	4	.	.	PUNCT
fcis-1883	217	1	doi:10.1152	doi:10.1152	NOUN
fcis-1883	217	2	/	/	SYM
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fcis-1883	217	5	25	25	NUM
fcis-1883	217	6	]	]	PUNCT
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fcis-1883	217	8	j	j	PROPN
fcis-1883	217	9	,	,	PUNCT
fcis-1883	217	10	garcia	garcia	PROPN
fcis-1883	217	11	-	-	PUNCT
fcis-1883	217	12	dorado	dorado	NOUN
fcis-1883	217	13	d	d	PROPN
fcis-1883	217	14	,	,	PUNCT
fcis-1883	217	15	hernando	hernando	PROPN
fcis-1883	217	16	v	v	PROPN
fcis-1883	217	17	,	,	PUNCT
fcis-1883	217	18	soler	soler	PROPN
fcis-1883	217	19	-	-	PUNCT
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fcis-1883	217	21	j.	j.	PROPN
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fcis-1883	217	23	-	-	PUNCT
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fcis-1883	217	28	activity	activity	NOUN
fcis-1883	217	29	during	during	ADP
fcis-1883	217	30	early	early	ADJ
fcis-1883	217	31	reperfusion	reperfusion	NOUN
fcis-1883	217	32	contributes	contribute	VERB
fcis-1883	217	33	to	to	ADP
fcis-1883	217	34	cell	cell	NOUN
fcis-1883	217	35	death	death	NOUN
fcis-1883	217	36	after	after	ADP
fcis-1883	217	37	myocardial	myocardial	ADJ
fcis-1883	217	38	ischemia	ischemia	NOUN
fcis-1883	217	39	.	.	PUNCT
fcis-1883	218	1	circ	circ	PROPN
fcis-1883	218	2	res	re	NOUN
fcis-1883	218	3	.	.	PUNCT
fcis-1883	219	1	2005;97(5):465	2005;97(5):465	NUM
fcis-1883	219	2	-	-	SYM
fcis-1883	219	3	473	473	NUM
fcis-1883	219	4	.	.	PUNCT
fcis-1883	219	5	doi:10.1161/01.res.0000181170.87738.f3	doi:10.1161/01.res.0000181170.87738.f3	NOUN
fcis-1883	220	1	[	[	X
fcis-1883	220	2	26	26	NUM
fcis-1883	220	3	]	]	X
fcis-1883	220	4	khalil	khalil	PROPN
fcis-1883	220	5	pn	pn	PROPN
fcis-1883	220	6	,	,	PUNCT
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fcis-1883	220	8	c	c	NOUN
fcis-1883	220	9	,	,	PUNCT
fcis-1883	220	10	huss	huss	PROPN
fcis-1883	220	11	r	r	PROPN
fcis-1883	220	12	,	,	PUNCT
fcis-1883	220	13	et	et	PROPN
fcis-1883	220	14	al	al	PROPN
fcis-1883	220	15	.	.	PROPN
fcis-1883	220	16	calpain	calpain	NOUN
fcis-1883	220	17	inhibition	inhibition	NOUN
fcis-1883	220	18	reduces	reduce	VERB
fcis-1883	220	19	infarct	infarct	ADJ
fcis-1883	220	20	size	size	NOUN
fcis-1883	220	21	and	and	CCONJ
fcis-1883	220	22	improves	improve	VERB
fcis-1883	220	23	global	global	ADJ
fcis-1883	220	24	hemodynamics	hemodynamic	NOUN
fcis-1883	220	25	and	and	CCONJ
fcis-1883	220	26	left	leave	VERB
fcis-1883	220	27	ventricular	ventricular	ADJ
fcis-1883	220	28	contractility	contractility	NOUN
fcis-1883	220	29	in	in	ADP
fcis-1883	220	30	a	a	DET
fcis-1883	220	31	porcine	porcine	NOUN
fcis-1883	220	32	myocardial	myocardial	ADJ
fcis-1883	220	33	ischemia	ischemia	NOUN
fcis-1883	220	34	/	/	SYM
fcis-1883	220	35	reperfusion	reperfusion	NOUN
fcis-1883	220	36	model	model	NOUN
fcis-1883	220	37	.	.	PUNCT
fcis-1883	221	1	eur	eur	PROPN
fcis-1883	221	2	j	j	PROPN
fcis-1883	221	3	pharmacol	pharmacol	PROPN
fcis-1883	221	4	.	.	PUNCT
fcis-1883	222	1	2005;528(13):124	2005;528(13):124	NUM
fcis-1883	222	2	-	-	SYM
fcis-1883	222	3	131	131	NUM
fcis-1883	222	4	.	.	PUNCT
fcis-1883	223	1	doi:10.1016	doi:10.1016	PROPN
fcis-1883	223	2	/	/	SYM
fcis-1883	223	3	j.ejphar.2005.10.032	j.ejphar.2005.10.032	X
fcis-1883	224	1	[	[	X
fcis-1883	224	2	27	27	NUM
fcis-1883	224	3	]	]	X
fcis-1883	224	4	whelan	whelan	PROPN
fcis-1883	224	5	rs	rs	PROPN
fcis-1883	224	6	,	,	PUNCT
fcis-1883	224	7	kaplinskiy	kaplinskiy	NOUN
fcis-1883	224	8	v	v	NOUN
fcis-1883	224	9	,	,	PUNCT
fcis-1883	224	10	kitsis	kitsis	PROPN
fcis-1883	224	11	rn	rn	PROPN
fcis-1883	224	12	.	.	PROPN
fcis-1883	224	13	cell	cell	NOUN
fcis-1883	224	14	death	death	NOUN
fcis-1883	224	15	in	in	ADP
fcis-1883	224	16	the	the	DET
fcis-1883	224	17	pathogenesis	pathogenesis	NOUN
fcis-1883	224	18	of	of	ADP
fcis-1883	224	19	heart	heart	NOUN
fcis-1883	224	20	disease	disease	NOUN
fcis-1883	224	21	:	:	PUNCT
fcis-1883	224	22	mechanisms	mechanism	NOUN
fcis-1883	224	23	and	and	CCONJ
fcis-1883	224	24	significance	significance	NOUN
fcis-1883	224	25	.	.	PUNCT
fcis-1883	225	1	annu	annu	PROPN
fcis-1883	225	2	rev	rev	PROPN
fcis-1883	225	3	physiol	physiol	PROPN
fcis-1883	225	4	.	.	PUNCT
fcis-1883	226	1	2010;72:19	2010;72:19	NUM
fcis-1883	226	2	-	-	SYM
fcis-1883	226	3	44	44	NUM
fcis-1883	226	4	.	.	PUNCT
fcis-1883	227	1	doi:10.1146	doi:10.1146	NOUN
fcis-1883	227	2	/	/	SYM
fcis-1883	227	3	annurev.physiol.010908.163111	annurev.physiol.010908.163111	ADJ