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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 12 No. 12 (2022): December 2022
				
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									Research Articles
							
		



	
		  	 

		
	
		Anti-obesity effect of Microalga, Melosira nummuloieds ethanolic extract in high-fat-diet-induced obesity C57BL/6J mice
	


	
	
		

							
					Authors

						
							
								Injue Yun
							
																																		
	
							
								Jiwon Choi
							
																																		
	
							
								Hyeonjeong Choe
							
																																		
	
							
								Ki-ok Kim
							
																																		
	
							
								Gyung min Go
							
																																		
	
							
								Dae-Hee Lee
							
																																		
	
							
								Mi-Yeon Kim
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v12i12.1002
						
					
				
			

						
										
					Abstract

					Background: Melosira nummuloides is a microalga belonging to the Melosiracease diatom. The ability of the diatoms to mass-produce essential fatty acids and carotenoid pigments was reported, which has driven research and their industrial application. Melosira nummuloides mass-cultivated with Jeju Lava sea water contains fucoxanthin, which has excellent biological properties such as antioxidant, anti-inflammatory, anti-cancer, and anti-obesity activities. The effect of M. nummuloides ethanolic extract (MEE) on the reduction of fat accumulation was evaluated.
Methods: C57BL/6J mice fed a high-fat diet (HFD) were treated over 8 weeks with Melosira ethanolic extract. Cholesterol in serum and triglyceride in liver after the 8-week were evaluated. The expression of SREBP-1c, FAS, PPAR-γ, SCD-1 and p-AMPK were measured by western blotting respectively.
Results: The MEE-treated C57BL/6J showed significant body weight and visceral fat loss compared to HFD group. Cholesterol in serum and triglyceride levels in liver showed a significant decrease in MEE groups. Levels of SREBP-1c, FAS, PPAR-γ and SCD-1 were low in mice fed an HFD+MEE.
Conclusion: These results show MEE reduces blood lipid levels by regulating the expression of factors related to lipid synthesis and adipocyte differentiation in adipose tissue and inhibiting new lipid synthesis in the liver. M. nummuloides ethanolic extract confirmed its suitability as an anti-obesity agent.

Keywords: Melosira nummuloides; C57BL/6J mice; obesity: weight loss; fatty acid synthesis

				
			
			

						
																																																													
						
		


		

						
										
					
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																			2022-12-02
																	

				
							

			
						
										

											
							
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									Vol. 12 No. 12 (2022): December 2022
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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