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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 12 No. 11 (2022): November 2022
				
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									Research Articles
							
		



	
		  	 

		
	
		Anti-inflammatory effect of Phytomarine R-L compound against lipopolysaccharide- induced pulmonary injury in BALB/c mice
	


	
	
		

							
					Authors

						
							
								Janani Gopi
							
																																		
	
							
								Francesco Marotta
							
																																		
	
							
								Sushmitha Sriramulu
							
																																		
	
							
								Antara Banerjee
							
																																		
	
							
								N.R. Rajesh Kanna
							
																																		
	
							
								Vignesh Palani
							
																																		
	
							
								Antonio Ayala
							
																																		
	
							
								Fang He
							
																																		
	
							
								R Vijayashree
							
																																		
	
							
								Surajit Pathak
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v12i11.1014
						
					
				
			

						
										
					Abstract

					Background: This study deals with the induction of lipopolysaccharide induced inflammation in animal model and treating this condition using phytomarine R-L compound (Bloomin’Age, Science of Living, Milan Italy) that is known to possess the anti-inflammatory properties and eventually determine their characteristics through the in-vivo experimentation.
Objective of the study:The present study was subjected to test the therapeutic anti-inflammatory/anti-oxidative and regenerative property of this phytomarine (SBF-LF) in an LPS-induced lung injury in mice models.  
 
Methods:Mice received an intra-nasal administration of LPS at a concentration of 1 mg/ml weekly per day in a week for four consecutive weeks followed by the oral administration of R-L compound at a concentration of 50 mg/kg body weight intermittently. Broncho-alveolar lavage fluids (BALF) as well as the lung tissues were periodically collected from the control and experimental groups for histological examination. Likewise, the lung tissue homogenate obtained from induction and treatment groups was assayed for myeloperoxidase (MPO) assay, superoxide dismutase (SOD) activity and elastase assay. 
Results: The results illustrated that LPS- induced mice group demonstrated an increased inflammatory cell infiltration causing an acute and persisting neutrophilic accumulation in the lung parenchyma with alveolar congestion. Furthermore, the influx of macrophages, lymphocytes as well as inflammatory mediators was observed during the BALF analysis. The treatment with R-L compound resulted in a significant decline in the permeation of inflammatory cells as observed by lung histology and BALF analysis. 
Conclusion: Thus, the exploitation of R-L compound with the experimental groups along with other assay methods confirmed its robust anti-inflammatory and antioxidant properties and suggested epithelial regenerative capacity. Further analyzing the efficacy of the R-L compound might help understanding its potential as a therapeutic option in clinical settings.

Keywords:Lungs, BALB/c mice, Lipopolysaccharide, anti-inflammatory, R-L compound

				
			
			

						
																																																																																		
						
		


		

						
										
					
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																			2022-11-22
																	

				
							

			
						
										

											
							
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									Vol. 12 No. 11 (2022): November 2022
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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