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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 13 No. 3 (2023): March 2023
				
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									Research Articles
							
		



	
		  	 

		
	
		In vivo evaluation of holocellulose and cellulose isolated from kumaizasa (Sasa senanensis) powder on bowel movements in rats
	


	
	
		

							
					Authors

						
							
								Hideo Hara
							
																																		
	
							
								Ryusuke Mifuru
							
																																		
	
							
								Yoshiro Ishikura
							
																																		
	
							
								Ryo Yokotani
							
																																		
	
							
								Naobumi Ishida
							
															
									Clinical Support Corporation, Ltd.
																	
																																		
	
							
								Takaaki Hara
							
																																		
	
							
								Shuji Ozaw
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v13i3.1078
						
					
				
			

						
										
					Abstract

					Background: Kumaizasa (Sasa senanensis Rehder) is a representative natural plant growing in Hokkaido, Japan, and has a history of being used in herbal medicine and as a health food option. Nishihira et. al. (2019) confirmed in a clinical trial that the kumaizasa dry powder had the effect of improving bowel movements of healthy volunteers. In this study, we evaluated the effect of the components of kumaizasa powder, like holocellulose (hemicellulose + cellulose) and cellulose, involved in the bowel movement of rats and tried to elucidate the role of each component.
Methods: Male rats (Slc:SD, weight 79~93 g) were administered kumaizasa powder (3000 mg/kg/day) orally, holocellulose (1500 mg/kg/day), cellulose (900mg /kg/day) or water using a stomach tube twice a day for 14 days.
Results: Among the intervention groups (kumaizasa powder, holocellulose, cellulose group) and control group (water), no significant differences were observed with changes in body weight and food consumption. All the feces were normal, with one exception of watery feces on day 2 in the cellulose group. Multigroup comparison by the Tukey-Kramer method showed that the dry weight of feces collected at day 14 in the kumaizasa powder group significantly increased as compared with that of the control group (p<0.01). This result confirmed that kumaizasa powder had the effect of increasing fecal amount. A paired t-test between each kumaizasa group and control group indicated that the cellulose increased the fecal dry weights and moisture content in feces, while the kumaizasa powder and the holocellulose increased only fecal dry weights.
Conclusion: It is shown that the holocellulose and cellulose of kumaizasa powder have the effect of increasing the bowel movement of rats by oral administration. It is also suggested that the cellulose increases the moisture content in the feces by swelling, while hemicellulose in the holocellulose acts as a prebiotic to regulate the moisture content in feces.

Keywords: Kumaizasa, Sasa senanensis Rehder, hemicellulose, cellulose, holocellulose, bowel movements

				
			
			

						
																																																																										
					
													Author Biography
											

						
								
																																							Naobumi Ishida,  Clinical Support Corporation, Ltd. 
																	

								
									Received Ph.D. degree from Hokkaido University
More than 35 experiences in pharmaceutical industries to invent and develop piperacillen/tazobactam
More than 12 years experiences in functional food to submit many functional food with claim to Japanese CAA

								

							


				
			
						
		


		

						
										
					
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						Published
					

					
																			2023-03-31
																	

				
							

			
						
										

											
							
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									Vol. 13 No. 3 (2023): March 2023
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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