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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 13 No. 6 (2023): June 2023
				
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									Research Articles
							
		



	
		  	 

		
	
		The effects of Dyglomera (Dichrostachys glomerata extract) on body fat percentage and body weight: a randomized, double- blind, placebo-controlled clinical trial
	


	
	
		

							
					Authors

						
							
								Janvier Youovop
							
																																		
	
							
								Guy Takuissu
							
															
									Ministry of Scientific Research, Cameroon
																	
																																		
	
							
								Christelle Mbopda
							
																																		
	
							
								Felix Nwang
							
																																		
	
							
								Raissa Ntentié
							
																																		
	
							
								Mary-Ann Mbong
							
																																		
	
							
								Boris Azantsa
							
																																		
	
							
								Harinder Singh
							
																																		
	
							
								Julius Oben
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v13i6.1088
						
					
				
			

						
										
					Abstract

					Introduction: Previous studies have shown the beneficial effects of Dyglomera®, a hydroethanolic extract of Dichrostachys glomerata, on inflammation as well as parameters linked to metabolic syndrome. Its effect on body fat was however not verified. The present study was therefore carried out to evaluate the anti-obesity effect of the Dyglomera®, on overweight and obese subjects.
Methods: This 12-week randomized, double-blind placebo-controlled trial had percentage body fat measured by dual-energy X-ray absorptiometry, body weight and body mass index set as efficacy endpoints.  On the other hand, key biochemical parameters were measured as secondary endpoints.  The values of these parameters at T12 compared to T0 for the placebo and Dyglomera® groups were used as a measure of the efficacy. 
Results: Subjects treated with Dyglomera® for 12 weeks showed significant differences, with 6.73 kg (p<0.05) decrease in the body weight and 22.85% (p<0.05) reduction in the percentage body fat. In addition, the markers of lipid profile, adipocytokines, glycemia and transaminases plasmatic activities were also improved by the intake of Dyglomera®.
Conclusions: This study shows that Dyglomera® effectively decreases the body weight in obese subjects after 12 weeks of treatment, which was accompanied by a reduction in the body fat and related disorders. Dyglomera®is a good agent for overweight and obesity management.

Keywords: Dichrostachys glomerata, Dyglomera®, body fat percentage, body weight, clinical trials.




				
			
			

						
																																																																											
						
		


		

						
										
					
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																			2023-06-30
																	

				
							

			
						
										

											
							
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									Vol. 13 No. 6 (2023): June 2023
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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