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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 1 No. 12 (2011): December 2011
				
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									Short Report
							
		



	
		  	 

		
	
		The Enhancing Effect of γ-Cyclodextrin Inclusion on γ-Tocotrienol-dependent Negative Growth Control of Mesothelioma Cells in a Xenograft Model
	


	
	
		

							
					Authors

						
							
								T. Yano
							
															
									Research Group of Nutritional Sciences, Faculty of Life Sciences, Toyo University, Gunma, 374-0193
																	
																																		
	
							
								A. Sato
							
															
									Research Group of Nutritional Sciences, Faculty of Life Sciences, Toyo University, Gunma, 374-0193
																	
																																		
	
							
								M. Sekine
							
															
									Research Group of Nutritional Sciences, Faculty of Life Sciences, Toyo University, Gunma, 374-0193
																	
																																		
	
							
								K. Kashiwagi
							
															
									Department of Experimental Pathology, Yokohama City University Graduate School of Medicine, Kanagawa, 315-0345
																	
																																		
	
							
								M. Ota
							
															
									Research Group of Nutritional Sciences, Faculty of Life Sciences, Toyo University, Gunma, 374-0193
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v1i12.110
						
					
				
			

						
										
					Abstract

					Background: Malignant mesothelioma is an aggressive cancer with no effective treatment options. Of phytochemicals, tocotrienol (T3), a member of vitamin E, is one of the most potent anti-mesothelioma agents, but the effectiveness in vivo is quite limited, due to its low bioavailability. In this study, we investigated if the oral treatment of γ-T3 inclusion with γ-cyclodextrin (CD) could improve the bioavailability and anticancer activity of the T3.
Findings: Using nude mice bearing MSTO-211H cells (a human malignant mesothelioma cell line), the effect of γ-T3 inclusion with γ-CD on γ-T3 level in tumor tissues, tumor growth, and its related mRNA levels were examined. The difference of tumor growth between the two groups had no statistical significance, but the latter showed a lower tendency compared with the former. In linked with this observation, the level of vascular endothelial growth factor mRNA required for in vivo tumor growth in γ-T3 inclusion with γ-CD group was lower than that in γ-T3 group, on the contrary, the level of γ-T3 level showed an opposite tendency.
Conclusion: Our study demonstrated that the bioavailability of γ-T3 was improved by an oral administration of a novel γ-T3 inclusion complex with CD. Furthermore, the improvement of the bioavailability contributed to the increase of anticancer activity of γ-T3 in vivo.
Keywords: Anti-cancer agent, bioavailability, cyclodextrin, mesothelioma, tocotrienol.

				
			
			

						
																																															
						
		


		

						
										
					
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																			2011-12-30
																	

				
							

			
						
										

											
							
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									Vol. 1 No. 12 (2011): December 2011
								
							

						
					
											
							
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								Short Report
							

						
					
									

			
						
										
					
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