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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 1 No. 11 (2011): November 2011
				
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									Research Articles
							
		



	
		  	 

		
	
		The protective effect of soybean phytochemicals on androgen responsive human prostate cancer cells LNCaP is likely mediated through modulation of hormone/cytokine-dependent pathways
	


	
	
		

							
					Authors

						
							
								Thomas Wang
							
															
									USDA, ARS, BHNRC, Diet, Genomics, and Immunology Laboratory, Beltsville, MD 20854
																	
																																		
	
							
								Stephen M. Boue
							
															
									USDA, Southern Regional Research Center, New Orleans, LA 70124
																	
																																		
	
							
								Hari B. Krishnan
							
															
									USDA, Plant Genetics Research Unit, ARS, Columbia, MO 65211
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v1i11.113
						
					
				
			

						
										
					Abstract

					Background: Population studies suggested that consumption of a soy rich diet provides protective effects against several chronic diseases, including prostate cancer. However, the active components in soy as well as the mechanisms of action of soy’s protective effects remain unclear. It would be important to elucidate these questions to support the use of soy in the prevention of chronic disease.
Methods: A cell culture model and molecular techniques were used as tools to identify a molecular signature induced by soy-derived phytochemicals.
Results: Soy phytochemicals inhibit growth of androgen responsive prostate cancer cells. Global gene expression analysis using DNA microarray and real time PCR analysis identified multiple pathways affected by the soy-derived phytochemicals genistein, daidzein, equol, and glyceollins in the androgen responsive human prostate cancer cell LNCaP. These pathways included androgen receptor-dependent pathways, insulin-like growth factors pathways, and cell cycle-related pathways. Soy-derived phytochemicals modulated these pathways in a concentration-dependent fashion.
Conclusion: Taking into consideration the physiological achievable concentration of diet-derived soy phytochemicals, we propose the concentration-dependent cancer protective effect is likely mediated through modulation of hormone/cytokine-dependent pathways.

				
			
			

						
																																	
						
		


		

						
										
					
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																			2011-11-30
																	

				
							

			
						
										

											
							
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									Vol. 1 No. 11 (2011): November 2011
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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