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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 13 No. 10 (2023): October 2023
				
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									Clinical Trial
							
		



	
		  	 

		
	
		Alleviating the physical discomfort in healthy individuals with Moringa seed extract: a randomized, double-blind, placebo-controlled, parallel-group trial
	


	
	
		

							
					Authors

						
							
								Aya Abe
							
																																		
	
							
								Mahendra P. Kapoor
							
																																		
	
							
								So Morishima
							
																																		
	
							
								Derek Timm
							
																																		
	
							
								Atsushi Nakajima
							
																																		
	
							
								Makoto Ozeki
							
																																		
	
							
								Norio Sato
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v13i10.1142
						
					
				
			

						
										
					Abstract

					Background: Moringa oleifera is well recognized for its rich nutritional content and diverse bioactive compounds. Moringa, abundant in various bioactive compounds such as flavonoids and alkaloids present across all plant parts including leaves, stems, and roots, is especially rich in glucomoringin within its seeds. The antioxidant activity of moringin has already been verified in numerous cellular and animal experiments.
Objective: The study investigates the effects of Moringa seed extract (MSE), abundant in glucomoringin, on fatigue-related physical discomfort and sleep quality, as indicators of quality of life (QOL) in healthy individuals.
Methods: A randomized, double-blind, placebo-controlled, parallel-group study was conducted, administering MSE containing 12 mg of glucomoringin or placebo to healthy adult males and females daily for four consecutive weeks. Quality of life (QOL) questionnaire on fatigue, physical discomfort, sleep, and motivation was evaluated using a visual analog scale (VAS) at the start of the study and the end of each subsequent week until week 4. The impact on QOL was assessed through subjective evaluations and oxidative stress markers.
Results: As a result, the efficacy of MSE intake in reducing stiff shoulder/neck pain, joint pain, and muscle pain was confirmed. Based on the oxidative stress markers, significant effects were observed among the participants with relatively high oxidative stress. A greater improvement in physical discomfort, reduced fatigue, and enhanced sleep quality were also noticed among female participants with MSE consumption. 
Conclusion: MSE consumption has showed potential in lowering physical discomfort brought on by exhaustion, promoting overall QOL, and improving sleep quality. (UMIN000049070)

Keywords:moringa; moringin; glucomoringin; physical discomfort; sleep quality; fatigue; pain

				
			
			

						
																																																													
						
		


		

						
										
					
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						Published
					

					
																			2023-10-04
																	

				
							

			
						
										

											
							
								Issue
							

							
								
									Vol. 13 No. 10 (2023): October 2023
								
							

						
					
											
							
								Section
							

							
								Clinical Trial
							

						
					
									

			
						
										
					
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