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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 13 No. 10 (2023): October 2023
				
				/
			
	
			
									Short Communication
							
		



	
		  	 

		
	
		Perch essence prevents cell death to improve skeletal muscle mass and strength: Evidence from in vitro and human model
	


	
	
		

							
					Authors

						
							
								Chih-Cheng Lin
							
																																				
																		
										https://orcid.org/0000-0003-1842-666X
									
								
													
	
							
								Chih-Yu Hsieh
							
																																		
	
							
								Ling-Ni Chen
							
																																		
	
							
								Mao-Hsiang Lee
							
																																		
	
							
								Yi-Han Ting
							
																																		
	
							
								Ting-Ming Wang
							
																																		
	
							
								Jia-Feng Chang
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v13i10.1177
						
					
				
			

						
										
					Abstract

					Background:Fish protein supplementation may maintain muscle strength and prevent sarcopenia as it contains a complex array of macro- and micronutrients essential for building the skeletal muscle. 
Objective:The aim of this study was to evaluate the influence of perch essence (PE) supplementation on muscle mass and muscle function of through human and cell model. 
Methods:The open label clinical trial was conducted to assess the therapeutic effect of PE on muscle mass improvement. The mouse skeletal muscle cell (C2C12) model of muscle atrophy was analyzed for cell viability. 
Results:Our results showed PE contained abundant branched chain amino acid, taurine, hydroxyproline and collagen. After one month of supplementation with PE in our human model, there was a significant increase in muscle mass in the whole body and all parts of the body, with an increase of 1.55 % in the whole body, 1.79% in the trunk, 1.64% in the arms and 1.38% in the legs. The percentage of subcutaneous fat in the trunk, arms and legs also decreased significantly by 2.49%, 3.21% and 3.40% respectively. PE supplementation also improves muscle grip strength, especially with the dominant hand. The cell model results demonstrated that PE could effectively prevent skeletal muscle cell from death induced by dexamethasone. 
Conclusion:This study suggests that the branched chain amino acids, taurine, hydroxyproline and collagen in PE have the potential to serve as a good source of dietary supplements for the improvement of skeletal muscle mass and strength through cell protection.

Keywords:branched chain amino acid, collagen, perch, skeletal muscle, sarcopenia

				
			
			

						
																																																													
						
		


		

						
										
					
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						Published
					

					
																			2023-10-30
																	

				
							

			
						
										

											
							
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									Vol. 13 No. 10 (2023): October 2023
								
							

						
					
											
							
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								Short Communication
							

						
					
									

			
						
										
					
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