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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 1 No. 9 (2011): September 2011
				
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									Review Articles
							
		



	
		  	 

		
	
		Nutrigenomics of Neuradaptogen Amino-Acid-Therapy and Neurometabolic Optimizers: Overcoming carbohydrate bingeing and overeating through neurometabolic mechanisms
	


	
	
		

							
					Authors

						
							
								Kenneth Blum
							
															
									Department of Psychiatry, University of Florida, College of Medicine, Mcknight Brain Institute, Gainesville, Florida
																	
																																		
	
							
								Debasis Bagchi
							
															
									Innovative Research and Clinical Trials, Iovate Inc., Toronto
																	
																																		
	
							
								Abdalla Bowirrat
							
															
									Clinical Neuroscience and Population Genetics, Ziv Government Medical Center
																	
																																		
	
							
								B. William Downs
							
															
									Department of Personalized Medicine, Reward Deficiency Solutions, LLC, San Diego, California
																	
																																		
	
							
								Roger L. Waite
							
															
									Department of Personalized Medicine, Reward Deficiency Solutions, LLC, San Diego, California
																	
																																		
	
							
								John Giordano
							
															
									Deaprtment of Holistic Medicine, G and G Hoistic Addiction Treatment Center, North Miami Beach
																	
																																		
	
							
								Siohban Morse
							
															
									Deaprtment of Holistic Medicine, G and G Hoistic Addiction Treatment Center, North Miami Beach
																	
																																		
	
							
								Margaret Madigan
							
															
									Department of Personalized Medicine, Reward Deficiency Solutions, LLC, San Diego, California
																	
																																		
	
							
								Jaclyn M. Downs
							
															
									Department of Personalized Medicine, Reward Deficiency Solutions, LLC, San Diego, California
																	
																																		
	
							
								Eric R. Braverman
							
															
									Department of Clinical Neurology, Path Foundation NY, New York, New York
																	
																																		
	
							
								Margaret Polanin
							
															
									Department of Neurological Surgery, Weill Cornell College of Medicine, New York, New York
																	
																																		
	
							
								Debmayla Barh
							
															
									Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal 721172
																	
																																		
	
							
								Frank Fornari
							
															
									Dominion Diagnostics Inc. North Kingstown, Rhode Island
																	
																																		
	
							
								Thomas Simpatico
							
															
									Community Mental Health Institute, Center for Clinical & Translational Science, University of Vermont and Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v1i9.121
						
					
				
			

						
										
					Abstract

					Despite progress that has been made in the treatment of obesity, the epidemic continues to rise worldwide. While pharmacological treatment of obesity may be effective, medications may have significant side effects and can be potentially fatal. This review will provide significant evidence to substantiate the existence of Reward Deficiency Syndrome in Obesity and the role of catecholaminergic pathways in aberrant substance seeking behavior, in particular cravings for carbohydrates. The genetic basis for generalized craving behavior will be established. Evidence to support the augmentation of precursor amino acid therapy and enkephalinase, MOA and COMT inhibition leading to enhanced levels of neurotransmitters: serotonin, enkephalins, GABA and dopamine/norepinephrine as well increasing insulin sensitivity (affecting dopamine neuronal synthesis regulation) through the use of certain neurometabolic optimizers will also be provided. This review article cites many published studies to support a conceptual paradigm shift towards the use of this proposed nutrigenomic formula. The analysis and research preceding this formulation is outlined. This formulation has a generalized anti-craving effect and can inhibit carbohydrate bingeing, inducing significant healthy fat loss and prevention of relapse. This is the first time that components of this formula have been combined, at the dosage levels indicated with the goal of promoting successful and sustainable body recomposition. We are encouraging other laboratories to further evaluate Neuroadtagen Amino-Acid Therapy (NAAT)/Nurometabolic optimizers as a putative anti-obesity complex in larger controlled blinded studies and await interpretation of must these needed studies. 
Keywords: NAAT, Dopamine, Genes, Polymorphisms, Obesity, Craving Behavior, Overeating, Reward Deficiency Syndome, Nutrigenomics.

				
			
			

						
																																																																																																														
						
		


		

						
										
					
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						Published
					

					
																			2011-09-29
																	

				
							

			
						
										

											
							
								Issue
							

							
								
									Vol. 1 No. 9 (2011): September 2011
								
							

						
					
											
							
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								Review Articles
							

						
					
									

			
						
										
					
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