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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 13 No. 10 (2023): October 2023
				
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									Research Articles
							
		



	
		  	 

		
	
		The possible anti-inflammatory properties of hydro-ethanolic extract of Oregano
	


	
	
		

							
					Authors

						
							
								Armenuhi Moghrovyan
							
																																		
	
							
								Mikayel Ginovyan
							
																																		
	
							
								Nikolay Avtandilyan
							
																																		
	
							
								Lilya Parseghyan
							
																																		
	
							
								Armen Voskanyan
							
																																		
	
							
								Naira Sahakyan
							
																																		
	
							
								Anna Darbinyan
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v13i10.1211
						
					
				
			

						
										
					Abstract

					Backgrounds: Plant compounds are of great value due to their analgesic, anti-inflammatory, cytotoxic, and other characteristics. This study aimed to examine the chemical composition and impact of the Origanum vulgare hydro-ethanolic extract on nociceptive behavior and anti-inflammatory properties in in vivo mice models.
Methods: Gas chromatography-mass spectrometry and high-performance liquid chromatography techniques were employed to determine the major active phytochemicals of the extract. The effects of the extract on nociceptive reactions were evaluated using formalin and hot plate tests, while the anti-inflammatory effect was determined using the Carrageenan test. The methyl-thiazolyl-tetrazolium assay was applied to analyze growth-inhibiting properties of the extract on MCF-7 breast cancer cells.
Results: Various flavonoids and organic acids were identified in O. vulgare hydro-ethanolic extract. The extract possessed low cytotoxicity on MCF-7 cells as only 1 mg/mL or higher concentrations of the extract induced considerable growth inhibition. The formalin and hot plate tests demonstrated some sensitizing effects of the investigated extract (5 mg/kg) on mice. Moreover, the Carrageenan test revealed pronounced anti-inflammatory properties of the O. vulgare extract.
Conclusion: The potent biological activity of the wild oregano herb extract makes it a promising source for the development of medicinal preparations. 

Keywords: Nociceptive behavior, anti-inflammatory effect, Oregano, flavonoids, chemical composition, cytotoxicity, in vivo mice models.

				
			
			

						
																																																													
						
		


		

						
										
					
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																			2023-10-05
																	

				
							

			
						
										

											
							
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									Vol. 13 No. 10 (2023): October 2023
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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