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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 1 No. 9 (2011): September 2011
				
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									Research Articles
							
		



	
		  	 

		
	
		Effects of Portabella mushrooms on collagen-induced arthritis, inflammatory cytokines, and body composition in dilute brown non-agouti (DBA1) mice
	


	
	
		

							
					Authors

						
							
								Sandra Peterson
							
															
									Department of Nutritional Sciences, College of Human Environmental Sciences, Oklahoma State University, Stillwater; OK 74078
																	
																																		
	
							
								Edralin A. Lucas
							
															
									Department of Nutritional Sciences, College of Human Environmental Sciences, Oklahoma State University, Stillwater; OK 74078
																	
																																		
	
							
								Djibril Traore
							
															
									Department of Nutritional Sciences, College of Human Environmental Sciences, Oklahoma State University, Stillwater; OK 74078
																	
																																		
	
							
								Lawrance Christopher
							
															
									Department of Nutritional Sciences, College of Human Environmental Sciences, Oklahoma State University, Stillwater; OK 74078
																	
																																		
	
							
								Christine French
							
															
									Department of Nutritional Sciences, College of Human Environmental Sciences, Oklahoma State University, Stillwater; OK 74078
																	
																																		
	
							
								Stephen L. Clarke
							
															
									Department of Nutritional Sciences, College of Human Environmental Sciences, Oklahoma State University, Stillwater; OK 74078
																	
																																		
	
							
								Stanley A. Lightfoot
							
															
									VA Hospital, Oklahoma University Health Sciences Center, Oklahoma City, OK, 73104
																	
																																		
	
							
								Brenda J. Smith
							
															
									Department of Nutritional Sciences, College of Human Environmental Sciences, Oklahoma State University, Stillwater; OK 74078
																	
																																		
	
							
								Solo Kuvibidila
							
															
									Department of Nutritional Sciences, College of Human Environmental Sciences, Oklahoma State University, Stillwater; OK 74078
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v1i9.123
						
					
				
			

						
										
					Abstract

					Background: Exotic mushrooms have long been used in Asia for treatment and/or prevention of chronic diseases due to their immunomodulatory properties. However, the health benefits of portabella mushrooms (PM) (brown Agaricus bisporous), on collagen-induced arthritis (CIA) and associated complications, (i.e. loss of lean mass, increased fat mass and inflammatory cytokines), have not been previously investigated.
Methods: We investigated CIA pathogenesis, body composition and plasma levels of IL- 6, TNF-α and sICAM1 in DBA1 female mice fed either the AIN76 diet or the same diet fortified with 5% lyophilized PM (n=19-20/group). Ten mice/group were immunized with 100 µg bovine collagen type II on day 42 of the protocol, followed by 50 µg lipopolysaccharides on day 62, and euthanized on day 73-74. Cytokines were measured by ELISA.

Results: Compared to baseline diet, PM had: no protective effect from CIA since all collagen-immunized mice developed severe edema, bone erosion, and mononuclear cell infiltration in paws. In mice with and those without CIA, feeding a PM-fortified diet resulted in higher percent of body fat than feeding the baseline diet (p<0.05). After CIA induction, PM provided the following beneficial effects: (a) a smaller reduction in lean mass and absolute thymus weight; (b) a higher fat mass loss; and (c) lower plasma TNF-α levels (p <0.05). PM-fortification did not alter plasma IL-6 and sICAM1 regardless of CIA status; but it increased in vitro IL-6 secretion by mitogen-treated spleen cells.
Conclusion: Our data suggest that PM may reduce plasma TNF-α, attenuate lean mass loss and thymus atrophy associated with arthritis, and protect spleen cell function assessed by IL-6 secretion. However, PM-fortification did not attenuate overall CIA pathogenesis which may be due to lack of effect on plasma IL-6. Decreased TNF-α without alterations in IL-6 may reduce the risk of other conditions associated with chronic inflammation such as cardiovascular disease.
Key words: portabella mushrooms, inflammatory cytokines, collagen-induced arthritis, body composition, TNF-α, IL-6, thymus, DBA1 mice.

				
			
			

						
																																																																											
						
		


		

						
										
					
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						Published
					

					
																			2011-09-17
																	

				
							

			
						
										

											
							
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									Vol. 1 No. 9 (2011): September 2011
								
							

						
					
											
							
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