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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 13 No. 12 (2023): December 2023
				
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									Research Articles
							
		



	
		  	 

		
	
		Comparative analysis of the effect of fermented derivatives from Bactrian milk on the gut microbiome
	


	
	
		

							
					Authors

						
							
								Kozhakhmetov Samat
							
															
									National Laboratory Astana, Nazarbayev University, Astana, Z05H0P9, Kazakhstan
																	
																																		
	
							
								Tultabayeva Tamara
							
																																		
	
							
								Suieubayev Maxat
							
																																		
	
							
								Muhanbetganov Nurislam
							
																																		
	
							
								Pernebek Zhanel
							
																																		
	
							
								Tarzhanova Dinar
							
																																		
	
							
								Uyzbayeva Indira
							
																																		
	
							
								Khassenbekova Zhanagul
							
																																		
	
							
								Zhantureyeva Akmaral
							
																																		
	
							
								Jarmukhanov Zharkyn
							
																																		
	
							
								Kozhakhmetova Saniya
							
																																		
	
							
								Kushugulova Almagul
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v13i12.1247
						
					
				
			

						
										
					Abstract

					Background:The gut microbiome plays a vital role in maintaining intestinal homeostasis, and its modulation through dietary interventions has garnered considerable interest in improving human health. In this study, we investigated the effect of traditional Kazakh fermented milk products derived from camel milk on the gut microbiome of rats. 
Objective:The animals were divided into three groups: the Bactrian milk group (BCM), the camel yogurt group (CMY), and the camel cheese group (CMC). 
Results:After 4 weeks of intervention, the relative abundance of bacterial taxa varied significantly in the BCM and Bactrian milk derivative groups. The CMY group demonstrated a 2-fold increase in the relative abundance of the genus Ligilactobacillus (p=0.032), whereas the CMC group showed a 3-fold decrease (p=0.009). Prevotella_9 exhibited an inverse abundance vector in the CMY (p=0.0005) and CMC (p=0.0001) groups compared to the BCM group. Additionally, 53 metabolic pathways were predicted, each showing varying relative abundances in response to dietary interventions. Notably, the metabolic pathways associated with amines, polyamines, cell structure, fatty acids, and nucleoside and nucleotide biosynthesis underwent the greatest changes. 
Conclusion:Consumption of camel milk yogurt led to an increase in biodiversity and abundance in the gut microbiota (p<0.01), as evidenced by Shannon and Simpson's indices. In summary, our study demonstrates that fermented camel milk products significantly influence the gut microbiome and metabolic pathways.

Keywords: Bactrian camel milk, gut microbiota, rats, yogurt, soft cheese
				
			
			

						
																																																																																																													
					
													Author Biography
											

						
								
																																							Kozhakhmetov Samat,  National Laboratory Astana, Nazarbayev University, Astana, Z05H0P9, Kazakhstan 
																	

								
									Leading Researcher of Microbiome Laboratory
								

							


				
			
						
		


		

						
										
					
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						Published
					

					
																			2023-12-11
																	

				
							

			
						
										

											
							
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									Vol. 13 No. 12 (2023): December 2023
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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