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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 1 No. 8 (2011): August 2011
				
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									Research Articles
							
		



	
		  	 

		
	
		The Effects of Intravenous Vitamin C Administration on hs-CRP and Tumor Necrosis Factor-α Levels in Haemodialysis Patients
	


	
	
		

							
					Authors

						
							
								Hamid Taiebi Khosroshahi
							
															
									Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz
																	
																																		
	
							
								Yashar Talebi
							
															
									Department of Nephrology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz
																	
																																		
	
							
								Siamak Ahmadzadeh
							
															
									Department of Nephrology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz
																	
																																		
	
							
								Afshin Habibzadeh
							
															
									c
																	
																																		
	
							
								Seyyed Ehsan Mousavi
							
															
									Department of Nephrology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz
																	
																																		
	
							
								Mohammadreza Khalilzadeh
							
															
									Hemodialysis Center, Imam Reza Hospital, Tabriz
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v1i8.125
						
					
				
			

						
										
					Abstract

					Background: It has been proved that pre-inflammatory factors increase mortality and morbidity of cardio-vascular diseases especially in hemodialysis patients. There is a great evidence for the increase of pre-inflammatory factors and vitamin C deficiency in dialysis patients. Limited data, however, are available regarding the effects of vitamin C supplementation on reduction of inflammatory markers in such patients.
Objectives: The aim of this study is to determine the changes of hs-CRP and Tumor Necrosis Factor-α (TNF-α) levels after administration of vitamin C in End Stage Renal Disease patients (ESRD) on Hemodialysis 
Methods and Materials: In this clinical trial, vitamin C was administered intravenously (IV), (500 mg two times per week) for 2 months in 41 chronic hemodialysis patients and the hs-CRP and TNF-α levels of these patients were compared with a control group with no vitamin C as treatment. Besides hs-CRP and TNF-α, detailed laboratory results were evaluated before and after the study. The statistical analysis was performed using SPSS version 16 at the end of the study. 
Results: The hs-CRP and TNF-α levels reduced significantly in hemodialysis patients after vitamin C supplementation (hs-CRP decreased from 7.27±3.70 to 6.60± 3.75, P< 0.001 and TNF-α decreased from 25.61±12.28 to 22.82±22.83, P= 0.006), whereas the levels of these pro-inflammatory factors increased in hemodialysis patients without vitamin C supplementation (hs-CRP increased from 7.13±3.56 to 7.73±3.83, P= 0.049 and TNF-α increased from 21.32±5.64 to 23.63±15.59, P= 0.353). Vitamin C supplementation also reduced ESR level and increased Hb level significantly but it had no influence on lipid profile.
Conclusion: According to the findings of this study, it seems that vitamin C administration can reduce hs-CRP and TNF-α level in hemodialysis patients and as a result prevent atherosclerosis. It can be concluded that administration of vitamin C supplementation is beneficial in hemodialysis patients.
Key words: hemodialysis, hs-CRP, TNF-α, Vitamin C

				
			
			

						
																																																						
						
		


		

						
										
					
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																			2011-08-30
																	

				
							

			
						
										

											
							
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									Vol. 1 No. 8 (2011): August 2011
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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