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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 1 No. 5 (2011): May 2011
				
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									Research Articles
							
		



	
		  	 

		
	
		Dietary Supplementation of Fructooligosaccharides Reduces Hepatic Steatosis Associated with Insulin Resistance in Obese Zucker Rats
	


	
	
		

							
					Authors

						
							
								Lydia Kaume
							
															
									Food Science Department, University of Arkansas, 2650 N. Young Avenue, Fayetteville AR, 72704
																	
																																		
	
							
								William Gilbert
							
															
									Food Science Department, University of Arkansas, 2650 N. Young Avenue, Fayetteville AR, 72704
																	
																																		
	
							
								Vidya Gadang
							
															
									Food Science Department, University of Arkansas, 2650 N. Young Avenue, Fayetteville AR, 72704
																	
																																		
	
							
								Latha Devareddy
							
															
									Food Science Department, University of Arkansas, 2650 N. Young Avenue, Fayetteville AR, 72704
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v1i5.130
						
					
				
			

						
										
					Abstract

					Background: One in five adults in the United States is obese as defined by a body mass index of 30 kg/m2. Obesity is associated with metabolic syndrome, a combination of medical conditions including cardiovascular disease, type 2 diabetes, hypertension, hypercholesterolemia, and hypertriglyceridemia. These conditions present challenges to the medical care system and require a multifaceted approach through a variety of interventions. This study investigated the effects of fructooligosaccharides (FOS) at the level of 5 % (w/w) in alleviating the complications associated with metabolic syndrome.
Methods: The study was carried out using thirty-six, three-month old female lean and obese Zucker rats housed in an environmentally controlled laboratory. The Zucker rats were divided into three groups (N=12): Lean (L-CTRL) and obese controls (O-CTRL) and obese-FOS (O-FOS). The controls received AIN-93M purified rodent diet and the animals in the O-FOS group were fed AIN-93M diet modified to contain 5.0% FOS (w/w). After 100 days of treatment, the rats were fasted for 12 hours and sacrificed. Tissue and organs of interest, and blood were collected for analysis. Serum concentrations of the following were determined: glucose, glycosylated hemoglobin (HbA1c), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG), and insulin. Gravimetric quantification of liver lipids was performed and peroxisome proliferator-activated receptor-γ (PPAR-γ) gene expression was determined in white adipose tissue by qRT-PCR.
Results: No significant differences were observed in the serum lipids, fasting blood glucose, HbA1c and PPAR-γ gene expression in white adipose tissue of O-FOS group compared to O-CTRL group. FOS supplementation significantly lowered the percent total liver lipids by 12% with a subsequent reduction in the liver weights compared to O-CTRL rats. Serum insulin concentrations were lowered 3.6 fold in O-FOS group compared to O-CTRL (P < 0.05). 
Conclusion: Based on these findings we conclude that dietary supplementation of 5% FOS (w/w) may reduce hepatic steatosis and the risk for non-alcoholic fatty liver disease (NAFLD) associated with insulin resistance without changes in blood lipids and glucose levels.
Key words: Dietary fiber, Fructooligosaccharide, Hepatosteatosis, Liver lipids, Non-alcoholic fatty liver disease (NAFLD), Zucker.

				
			
			

						
																																								
						
		


		

						
										
					
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																			2011-05-24
																	

				
							

			
						
										

											
							
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									Vol. 1 No. 5 (2011): May 2011
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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