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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 14 No. 2 (2024): February 2024
				
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									Research Articles
							
		



	
		  	 

		
	
		The effects of cyclodextran on plaque accumulation in healthy Japanese adults: A randomized, placebo-controlled, double-blind, parallel-group comparison study
	


	
	
		

							
					Authors

						
							
								Hikaru Teshima
							
																																		
	
							
								Hikaru Kato
							
																																		
	
							
								Yasuyuki Nakamura
							
																																		
	
							
								Naoko Suzuki
							
																																		
	
							
								Masahiko  Horiuchi
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v14i2.1324
						
					
				
			

						
										
					Abstract

					Background: Cyclo-isomalto-oligosaccharides (CI) have been reported to inhibit glucosyltransferases (GTF) in vitro. GTF is an enzyme related to oral plaque synthesis. However, there are few clinical studies to investigate the effect of CI on oral plaque via inhibiting GTF activity.

Objective: The purpose of this study was to evaluate the inhibitory effect of consuming CI-Dextran mix on plaque accumulation in healthy Japanese adults.

Methods: This randomized, placebo-controlled, double-blind, parallel-group comparison study was conducted from May 26, 2022, to September 16, 2022. Individuals who agreed to participate in the study were randomly assigned to the CI-Dextran mix group with 60 mg/day (n = 22), the CI-Dextran mix group with 600 mg/day (n = 11), or the placebo group (n = 22). The intervention period was three days, and the outcome of this study was the plaque index (PlI), an indicator of plaque accumulation. 

Results: Our results showed that the CI-Dextran mix group (600mg/day) had significantly lower post-intervention PlI values than the placebo group in a full analysis set (FAS). In individuals identified as prone to plaque accumulation among the FAS, both CI-Dextran mix groups showed significantly lower PlI values than the placebo group. No adverse events were observed during the study period, and consumption of the test food under the study conditions was considered safe.

Conclusions: Our results clearly indicated that a high dose of CI-Dextran mix (600 mg/day) could significantly reduce plaque formation in healthy Japanese adults, while a marginal reduction was noted for the group taking a low dose (60 mg/day). In particular, intake of both doses (CI-Dextran mix 60 mg/day and 600 mg/day) in individuals who were prone to plaque accumulation, could significantly inhibit plaque formation.

Keywords: CI-Dextran mix, cyclodextran, plaque inhibition, functional carbohydrates, isomaltooligosaccharide, Randomized Controlled Trial

Trial registration: UMIN000047901. Foundation: Nissin Sugar Co., Ltd.

				
			
			

						
																																															
						
		


		

						
										
					
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																			2024-02-27
																	

				
							

			
						
										

											
							
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									Vol. 14 No. 2 (2024): February 2024
								
							

						
					
											
							
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