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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 14 No. 6 (2024): June 2024
				
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									Research Articles
							
		



	
		  	 

		
	
		Improvement in autonomic balance through 12-week supplementation of a novel curcumin formulation in healthy Japanese adults: A randomized, placebo-controlled study
	


	
	
		

							
					Authors

						
							
								 Kuwabara Yoshitaka
							
																																		
	
							
								Hyunjin Lee
							
																																		
	
							
								Akiko Hirose
							
																																		
	
							
								Yuji  Makino
							
																																		
	
							
								Kyohei  Hashimoto
							
																																		
	
							
								Misaki  Sakata
							
																																		
	
							
								Tadashi  Watanabe 
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v14i6.1330
						
					
				
			

						
										
					Abstract

					Background: Curcumin has several health benefits due to its potent antioxidant and anti-inflammatory properties,

but its bioavailability is very low, limiting its potential. We have developed a novel curcumin formulation, TS-P1, which

has an 85.2-fold higher bioavailability of curcumin than raw curcumin.

 

Objective: To investigate the efficacy of TS-P1 on fatigue, mood status, and autonomic function.

 

Methods: Ninety healthy Japanese adults were randomized to the placebo or TS-P1 group and took either the placebo

or TS-P1 containing 150 mg of curcumin for 12 weeks. Visual Analogue Scale for Fatigue (VAS-F) scores, Profile of

Mood States Questionnaire second edition (POMS2) scores, and autonomic functions were measured every 4 weeks.

 

Results: Both groups showed an improvement in the VAS-F over the study period, but there was no significant

difference between the placebo and TS-P1 groups. However, the mean change from baseline in the anger and

depression scores of the POMS2, particularly in those aged 40 and over, in the TS-P1 group showed a greater range

of decline at week 12. The mean change from baseline in LnLF and LF/HF also decreased in the TS-P1 group. Blood

pressure also decreased in the TS-P1 group.

 

Conclusions: These data suggest that TS-P1 induced a parasympathetic dominant state, and that curcumin has an

important role in the regulation of autonomic balance. 12 weeks of supplementation of TS-P1 is expected to improve

both mood status and vascular function.

 

Trial registration: UMIN000050377

 

Foundation: Theravalues Corporation

 

Keywords: curcumin; TS-P1: Theracurmin Super; mood status; autonomic balance, parasympathetic dominance;

vascular function

				
			
			

						
																																																													
						
		


		

						
										
					
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																			2024-06-08
																	

				
							

			
						
										

											
							
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									Vol. 14 No. 6 (2024): June 2024
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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