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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 1 No. 3 (2011): March 2011
				
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									Research Articles
							
		



	
		  	 

		
	
		Effect of Mixed-Tocotrienols in Hypercholesterolemic Subjects
	


	
	
		

							
					Authors

						
							
								Kah Hay Yuen
							
															
									School of Pharmaceutical Sciences, University of Science Malaysia, 11800 Penang
																	
																																		
	
							
								Jia Woei Wong
							
															
									School of Pharmaceutical Sciences, University of Science Malaysia, 11800 Penang
																	
																																		
	
							
								Ai Beoy Lim
							
															
									School of Pharmaceutical Sciences, University of Science Malaysia, 11800 Penang
																	
																																		
	
							
								Bee Hong Ng
							
															
									School of Pharmaceutical Sciences, University of Science Malaysia, 11800 Penang
																	
																																		
	
							
								Wai Peng Choy
							
															
									School of Pharmaceutical Sciences, University of Science Malaysia, 11800 Penang
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v1i3.136
						
					
				
			

						
										
					Abstract

					Background: Studies on the cholesterol lowering activity of tocotrienols have yielded mixed results, with some showing cholesterol lowering effect while some showing no activity.
Aim: A randomized, double-blind, parallel group study was conducted to investigate the cholesterol lowering activity of tocotrienols. 
Methods: Thirty-two hypercholesterolemic subjects were randomly assigned to orally receive either 300 mg of mixed tocotrienols capsules daily or placebo capsules containing 300 mg of soya bean oil for a period of 6 months. The subjects were monitored before supplementation and monthly thereafter for their serum cholesterol as well as tocotrienol and tocopherol concentrations.
Results: The serum total cholesterol and low density lipoprotein (LDL) cholesterol of the subjects in the tocotrienol supplementation group were decreased significantly by -8.9 ± 0.9% and -12.8 ± 2.6% respectively after 4 months of supplementation and the reduction persisted till the end of the 6-month study, with a reduction of -10.8 ± 1.0% and  -17.3 ± 1.8%, respectively from baseline. Moreover, there was a 22-fold increase in the total tocotrienol concentrations from baseline during supplementation compared to the placebo group, while the concentration of α-tocopherol recorded only a modest increase. On the other hand, the serum cholesterol, total tocotrienol and α-tocopherol concentrations of subjects in the placebo group remained essentially unchanged.
Conclusions: Supplementation with mixed tocotrienols at dose of 300 mg per day resulted in the lowering of the serum total and LDL cholesterol levels after 5 months of supplementation.
Keywords: tocotrienols, cholesterol-lowering, total cholesterol, LDL cholesterol, tocopherols

				
			
			

						
																																															
						
		


		

						
										
					
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																			2011-03-31
																	

				
							

			
						
										

											
							
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									Vol. 1 No. 3 (2011): March 2011
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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