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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 5 No. 1 (2015): January 2015
				
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									Research Articles
							
		



	
		  	 

		
	
		Protein hydrolysates and recovery of muscle damage following eccentric  exercise
	


	
	
		

							
					Authors

						
							
								Dale M.J
							
															
									Alliance for Research in Exercise, Nutrition and Activity (ARENA), Sansom Institute for 
Health Research and School of Health Sciences, University of South Australia, Adelaide, 
Australia;
																	
																																		
	
							
								Thomson R.L
							
															
									Alliance for Research in Exercise, Nutrition and Activity (ARENA), Sansom Institute for 
Health Research and School of Health Sciences, University of South Australia, Adelaide, 
Australia;
																	
																																		
	
							
								Coates A.M
							
															
									Alliance for Research in Exercise, Nutrition and Activity (ARENA), Sansom Institute for 
Health Research and School of Health Sciences, University of South Australia, Adelaide, 
Australia;
																	
																																		
	
							
								Howe P.R.C
							
															
									Alliance for Research in Exercise, Nutrition and Activity (ARENA), Sansom Institute for 
Health Research and School of Health Sciences, University of South Australia, Adelaide, 
Australia; Clinical Nutrition Research Centre, University of Newcastle, Newcastle, 
Australia;
																	
																																		
	
							
								Brown A
							
															
									Murray Goulburn Co-operative Co. Ltd, Melbourne, Australia
																	
																																		
	
							
								Buckley J.D
							
															
									Alliance for Research in Exercise, Nutrition and Activity (ARENA), Sansom Institute for 
Health Research and School of Health Sciences, University of South Australia, Adelaide, 
Australia;
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v5i1.164
						
					
				
			

						
										
					Abstract

					Background: A whey protein hydrolysate (NatraBoost XR; WPHNB) has been shown to speed repair muscle damage. We sought to determine whether this benefit is specific to this hydrolysate to evaluate a marker for quality control.
Methods: Three hydrolysates of the same whey protein isolate (WPI) were prepared (WPHNB, WPH1 and WPH2). Isometric knee extensor strength was measured in 39 sedentary male participants before and after 100 maximal eccentric contractions of the knee extensors to induce muscle damage. Participants were then randomised to consume 250 ml of flavoured water (FW, n=9), or 250 ml of FW containing 25 g of either NatraBoost XR (n=3), WPH1 (n=9), WPH2 (n=9) or WPI (n=9). Strength was reassessed over the next seven days while the supplements were consumed daily. Fibroblasts were cultured for 48 hr in the presence of the different hydrolysates, WPI, saline or fetal bovine serum to ascertain effects on cell proliferation.
Results: Strength was reduced in all treatment groups after eccentric exercise (P<0.001). Strength recovered steadily over 7 days in the FW, WPI, WPH1 and WPH2 treatment groups (P<0.001), with no difference between treatments (P=0.87). WPHNB promoted faster strength recovery compared with the other treatments (P<0.001). Fibroblast proliferation was greater with WPHNB compared with saline, WPI or the other hydrolysates (P<0.001).
Conclusions: Promoting recovery from muscle damage seems unique to WPHNB. In vitro fibroblast proliferation may be a useful marker for quality control. It is not clear whether effects on fibroblast proliferation contribute to the in vivo effect of WPHNB on muscle damage.
Keywords: tissue repair, fibroblast proliferation, strength recovery, whey protein

				
			
			

						
																																																						
						
		


		

						
										
					
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																			2015-01-31
																	

				
							

			
						
										

											
							
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									Vol. 5 No. 1 (2015): January 2015
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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