


























































The influence of 2'-fucosyllactose on intestinal cell function: A comprehensive review of experimental studies
							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
	Skip to main content
	Skip to main navigation menu
		Skip to site footer


			

				
					
						Open Menu
					
										
																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
					Home
				
										
									
										Food Science Publisher
									
								
	
									
										Functional Food Center
									
								


							
	
				
					Current
				
							
	
				
					Archives
				
							
	
				
					About
				
										
									
										About the Journal
									
								
	
									
										Aims and Scope
									
								
	
									
										Contact
									
								
	
									
										Editing Services
									
								
	
									
										Editorial Team
									
								
	
									
										Express Peer Review
									
								
	
									
										Graphical Abstract
									
								
	
									
										Journal Insights
									
								
	
									
										Privacy Statement
									
								
	
									
										Submissions
									
								


							
	
				
					Announcements
				
							
	
				
					Search
				
							



				

																						
									
										
										Search
									
								

													

					

					
								
				
					Register
				
							
	
				
					Login
				
							



					

				
			

		

						
			
				


			
		
			
				Home
			
			/
		
	
			
				Archives
			
			/
		
	
				
					Vol. 15 No. 10 (2025): October 2025
				
				/
			
	
			
									Review Articles
							
		



	
		  	 

		
	
		The influence of 2'-fucosyllactose on intestinal cell function: A comprehensive review of experimental studies
	


	
	
		

							
					Authors

						
							
								Eko Sulistijono
							
																																		
	
							
								Loeki  Enggar Fitri
							
																																		
	
							
								Krisni Subandiyah
							
																																		
	
							
								Husnul Khotimah
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v15i10.1675
						
					
				
			

						
										
					Abstract

					Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal illnesses that causes preterm neonates to die. This occurs because Toll-like receptor 4 (TLR4) is activated by lipopolysaccharides, and preterm newborns' intestines express TLR4 at far greater levels than those of full-term neonates. NEC occurs in approximately 1 out of every 1,000 live births, with 5% to 10% incidence, and over 90% of cases are observed in infants younger than one month. Certain elements in breast milk have been found to help lower the risk of NEC. This systematic review aims to analyze various experimental studies related to the administration of 2’-Fucosyllactose (2'FL) that have the potential to induce improvement and therapy in NEC cases through intestinal cell function. There have not been many systematic reviews that specifically highlight the therapeutic effects of 2'FL on Necrotizing Enterocolitis (NEC), most of which still address the role of human milk oligosaccharides (HMOs). The results show that the search flow uses the PRISMA Flowchart; after screening 133 titles and abstracts, 55 studies were accessed to verify the feasibility of the full text. Overall, there were 5 studies selected in this study for a comprehensive review. According to the study's findings, 2'-FL, one of the HMOs, has a number of advantageous impacts on the host's immune system and digestive tract. Among many other advantages, HMOs have been shown to boost the immunological response to vaccinations, influence the makeup of the gut microbiota, and enhance the expression of genes related to gut function.


Keywords: NEC, HMOs, 2'-FL, Intestine, TLR4.

				
			
			

						
																																								
						
		


		

						
										
					
						Downloads
					

						
								
	
													


		
	[Abstract]

	
							
	
								
	
													


		
	[Full Article]

	
							


				

						
						
				
					
						Published
					

					
																			2025-10-06
																	

				
							

			
						
										

											
							
								Issue
							

							
								
									Vol. 15 No. 10 (2025): October 2025
								
							

						
					
											
							
								Section
							

							
								Review Articles
							

						
					
									

			
						
										
					
						License
					

																										Copyright (c) 2025 Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007

														This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

																Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License.

This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged.

By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained.

				

			
			

		

	




	




	


							



	

	

					
				About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives

 

			

		
		Open Journal Systems Hosting and Support by: OpenJournalSystems.com


	










