


























































Clinical assessment of CL22209, a standardized proprietary extract of  Asparagus racemosus , for mitigating vasomotor and menstrual symptoms in perimenopausal women:  A randomized, double-blind, placebo-controlled study
							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
	Skip to main content
	Skip to main navigation menu
		Skip to site footer


			

				
					
						Open Menu
					
										
																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
					Home
				
										
									
										Food Science Publisher
									
								
	
									
										Functional Food Center
									
								


							
	
				
					Current
				
							
	
				
					Archives
				
							
	
				
					About
				
										
									
										About the Journal
									
								
	
									
										Aims and Scope
									
								
	
									
										Contact
									
								
	
									
										Editing Services
									
								
	
									
										Editorial Team
									
								
	
									
										Express Peer Review
									
								
	
									
										Graphical Abstract
									
								
	
									
										Journal Insights
									
								
	
									
										Privacy Statement
									
								
	
									
										Submissions
									
								


							
	
				
					Announcements
				
							
	
				
					Search
				
							



				

																						
									
										
										Search
									
								

													

					

					
								
				
					Register
				
							
	
				
					Login
				
							



					

				
			

		

						
			
				


			
		
			
				Home
			
			/
		
	
			
				Archives
			
			/
		
	
				
					Vol. 15 No. 7 (2025): July 2025
				
				/
			
	
			
									Research Articles
							
		



	
		  	 

		
	
		Clinical assessment of CL22209, a standardized proprietary extract of Asparagus racemosus, for mitigating vasomotor and menstrual symptoms in perimenopausal women:  A randomized, double-blind, placebo-controlled study
	


	
	
		

							
					Authors

						
							
								Poonam  Yadav 
							
																																		
	
							
								Suman Yadav 
							
																																		
	
							
								Sai Sarada  Vedururu
							
																																		
	
							
								Gayatri Kiumari
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v15i7.1684
						
					
				
			

						
										
					Abstract

					Background: Vasomotor symptoms (VMS) and menstrual discomfort are prevalent and distressing manifestations during the menopausal transition in women, significantly impairing the quality of life (QoL). Asparagus racemosus Willd. (family: Asparagaceae) (Shatavari), a revered Rasayana herb in Ayurvedic medicine, has long been used to support female reproductive health. 

Objective: We investigated the therapeutic potential of CL22209, a standardized A racemosus root extract, in early perimenopausal women. Precisely, it assessed the extract’s ability to alleviate vasomotor symptoms, menstrual discomfort, and hormonal dysregulation through a comprehensive evaluation of symptom scores, reproductive hormone levels, ovarian follicle counts, and patient-reported outcomes, and ensuring its safety and tolerability over a 120-day supplementation.

Methods: In this randomized, double-blind, placebo-controlled investigation, 75 early perimenopausal women (aged 40–50 years) with mild-to-moderate VMS were assigned to receive either CL22209 (50- or 100 mg/day) or placebo over a period of 120 consecutive days. The primary endpoint was the change in total Menopausal Rating Scale (MRS) scores. Secondary outcomes included Hot Flash Weekly Weighted Score (HFWWS), Menstrual Symptom Questionnaire (MSQ) score, follicle count via ultrasonography, and serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH), and 17β-estradiol (E2) in the participants. Skin and hair quality, as well as patient-reported outcomes, were also assessed. Safety and tolerability were evaluated through monitoring of hematology, clinical biochemistry, urinalysis, and adverse events.

Results: Supplementation with CL22209 at both 50 mg and 100 mg/day significantly reduced MRS scores and HFWWS as compared to baseline and placebo (p < 0.001). Menstrual symptoms, particularly spasmodic and congestive dysmenorrhea, showed marked improvement. Notably, a dose-dependent modulation of FSH, LH, AMH, and E2 levels was observed. No serious adverse events were reported.

Conclusion: CL22209 demonstrates the efficacy and safety profile as a natural, non-hormonal intervention for alleviating perimenopausal symptoms, providing clinical benefits in symptom reduction, hormonal regulation, and dermatological well-being. The study provides the first clinical evidence of CL22209’s dual central and peripheral endocrine modulation, positioning it as a novel functional food for integrative women's health support during the menopausal transition.

Keywords: Asparagus racemosus (Shatavari), Functional Food, Hormonal balance, Menopausal Rating Scale (MRS), Perimenopause. Phytoestrogens, Safety, Vasomotor symptoms. 

				
			
			

						
																																								
						
		


		

						
										
					
						Downloads
					

						
								
	
													


		
	[Abstract]

	
							
	
								
	
													


		
	[Full Article]

	
							


				

						
						
				
					
						Published
					

					
																			2025-07-23
																	

				
							

			
						
										

											
							
								Issue
							

							
								
									Vol. 15 No. 7 (2025): July 2025
								
							

						
					
											
							
								Section
							

							
								Research Articles
							

						
					
									

			
						
										
					
						License
					

																										Copyright (c) 2025 Functional Foods in Health and Disease

														This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

																Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License.

This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged.

By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained.

				

			
			

		

	




	




	


							



	

	

					
				About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives

 

			

		
		Open Journal Systems Hosting and Support by: OpenJournalSystems.com


	










