




















































































9-cis β-carotene Inhibits Atherosclerosis Development in Female LDLR-/- Mice
							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
	Skip to main content
	Skip to main navigation menu
		Skip to site footer


			

				
					
						Open Menu
					
										
																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
					Home
				
										
									
										Food Science Publisher
									
								
	
									
										Functional Food Center
									
								


							
	
				
					Current
				
							
	
				
					Archives
				
							
	
				
					About
				
										
									
										About the Journal
									
								
	
									
										Aims and Scope
									
								
	
									
										Contact
									
								
	
									
										Editing Services
									
								
	
									
										Editorial Team
									
								
	
									
										Express Peer Review
									
								
	
									
										Graphical Abstract
									
								
	
									
										Journal Insights
									
								
	
									
										Privacy Statement
									
								
	
									
										Submissions
									
								


							
	
				
					Announcements
				
							
	
				
					Search
				
							



				

																						
									
										
										Search
									
								

													

					

					
								
				
					Register
				
							
	
				
					Login
				
							



					

				
			

		

						
			
				


			
		
			
				Home
			
			/
		
	
			
				Archives
			
			/
		
	
				
					Vol. 5 No. 2 (2015): February 2015
				
				/
			
	
			
									Research Articles
							
		



	
		  	 

		
	
		9-cis β-carotene Inhibits Atherosclerosis Development in Female LDLR-/- Mice
	


	
	
		

							
					Authors

						
							
								Noa Zolberg Relevy
							
															
									The Bert W. Strassburger Lipid Center; Sheba Medical Center, Tel-Hashomer, 5265601 Israel; 
The Mina and Everard Goodman Faculty of Life Science, Bar-Ilan University, Ramat-Gan, 
Israel
																	
																																		
	
							
								Ralph Rühl
							
															
									Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, 
Hungary
																	
																																		
	
							
								Ayelet Harari
							
															
									The Bert W. Strassburger Lipid Center; Sheba Medical Center, Tel-Hashomer, 5265601 Israel
																	
																																		
	
							
								Itamar Grosskopf
							
															
									The Bert W. Strassburger Lipid Center; Sheba Medical Center, Tel-Hashomer, 5265601 Israel
																	
																																		
	
							
								Iris Barshack
							
															
									Institute of Pathology, Sheba Medical Center, Tel-Hashomer; Sackler Faculty of Medicine, Tel-Aviv University, Israel
																	
																																		
	
							
								Ami Ben-Amotz
							
															
									N.B.T Israel
																	
																																		
	
							
								Uri Nir
							
															
									The Mina and Everard Goodman Faculty of Life Science, Bar-Ilan University, Ramat-Gan, 
Israel
																	
																																		
	
							
								Hugo Gottlieb
							
															
									Department of Chemistry, Bar-Ilan 
University, Ramat-Gan 52900, Israel.
																	
																																		
	
							
								Yehuda Kamari
							
															
									The Bert W. Strassburger Lipid Center; Sheba Medical Center, Tel-Hashomer, 5265601 Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel;
																	
																																		
	
							
								Dror Harats
							
															
									The Bert W. Strassburger Lipid Center; Sheba Medical Center, Tel-Hashomer, 5265601 Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel;
																	
																																		
	
							
								Aviv Shaish
							
															
									The Bert W. Strassburger Lipid Center; Sheba Medical Center, Tel-Hashomer, 5265601 Israel
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v5i2.172
						
					
				
			

						
										
					Abstract

					Background: Several epidemiological studies have shown that diets rich in carotenoids are associated with a reduced risk of cardiovascular disease. However, administration of synthetic all-trans b-carotene was reported to have no effect on cardiovascular disease. We previously showed that the 9-cis b-carotene-rich powder of the alga Dunaliella bardawil inhibits atherogenesis and reduces plasma non-HDL cholesterol levels in mice.
Context and purpose of this study: We sought to study whether isolated 9-cis b-carotene inhibits atherogenesis in a murine model of atherosclerosis.
Results: Twelve-week-old female LDL receptor knockout mice (LDLR-/-) were pretreated for  2 weeks with regular chow diet fortified with the alga Dunaliella powder, 9-cis β-carotene isomer, all-trans β-carotene isomer, or 9-cis retinoic acid, followed by 10 weeks of a high-fat diet with the same fortifications. In contrast to Dunaliella, 9-cis β-carotene did not inhibit the high fat diet-induced elevation of plasma cholesterol. In addition, diet fortification with Dunaliella powder, β-carotene isomers, or 9-cis retinoic acid did not change the plasma retinol or retinoic acid levels. Nevertheless, 9-cis β-carotene significantly inhibited atherogenesis compared to the control mice (39% reduction).
Conclusions: The results suggest that 9-cis β-carotene should be considered as an anti-atherogenic agent in the human diet.
Key words: Atherosclerosis, Dunaliella, 9CBC, LDLR-/- mice 
 

				
			
			

						
																																																																																									
						
		


		

						
										
					
						Downloads
					

						
								
	
													


		
	[Abstract]

	
							
	
								
	
													


		
	[Full Article]

	
							


				

						
						
				
					
						Published
					

					
																			2015-02-15
																	

				
							

			
						
										

											
							
								Issue
							

							
								
									Vol. 5 No. 2 (2015): February 2015
								
							

						
					
											
							
								Section
							

							
								Research Articles
							

						
					
									

			
						
										
					
						License
					

										Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License.

This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged.

By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained.

				

			
			

		

	




	




	


							



	

	

					
				About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives

 

			

		
		Open Journal Systems Hosting and Support by: OpenJournalSystems.com


	










