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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 5 No. 2 (2015): February 2015
				
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									Short Report
							
		



	
		  	 

		
	
		Water-soluble low-molecular-weight b-(1, 3–1, 6) D-Glucan inhibit cedar pollinosis
	


	
	
		

							
					Authors

						
							
								Tomoko Jippo
							
															
									Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, 
5-25-1 Fujishirodai, Suita, Osaka 565-0873, Japan;
																	
																																		
	
							
								Toshio Suzuki
							
															
									Department of Applied Chemistry and 
Bioengineering, Graduate School of Engineering, Osaka City University, Sugimoto 3-3-138, Sumiyoshi-ku, Osaka 558-8585, Japan
																	
																																		
	
							
								Harumi Sato
							
															
									Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, 
5-25-1 Fujishirodai, Suita, Osaka 565-0873, Japan;
																	
																																		
	
							
								Yuko Kobayashi
							
															
									Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, 
5-25-1 Fujishirodai, Suita, Osaka 565-0873, Japan;
																	
																																		
	
							
								Munekazu Shigekawa
							
															
									Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, 
5-25-1 Fujishirodai, Suita, Osaka 565-0873, Japan;
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v5i2.173
						
					
				
			

						
										
					Abstract

					Background: The incidences of allergenic diseases such as allergenic rhinitis, atopic dermatitis, asthma, and food allergies have increased in several countries. Mast cells have critical roles in various biological processes related to allergenic diseases. Mast cells express the high-affinity receptor for immunoglobulin (Ig) E on their surface. The interaction of multivalent antigens with surface-bound IgE causes the secretion of granule-stored mediators, as well as the de novo synthesis of cytokines. Those mediators and cytokines proceed the allergenic diseases. We investigated the effects of water-soluble, low-molecular-weight b-(1, 3–1, 6) D-glucan isolated from Aureobasidium pullulans 1A1 strain black yeast (LMW-b-glucan) on mast cell-mediated anaphylactic reactions. We reported that LMW-b-glucan dose-dependently inhibited the degranulation of mast cells. Furthermore, we found that orally administered LMW-b-glucan inhibited the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction in mice. Here, we examined if LMW-b-glucan had any effects on Japanese cedar pollinosis.
Findings: In a clinical study, a randomized, single-blind, placebo-controlled, parallel group study in 65 subjects (aged 22-62) was performed. This study was undertaken 3 weeks before the cedar pollen season and until the end of the cedar pollen season. During the study, all subjects consumed one bottle of placebo or LMW-b-glucan daily, and all subjects were required to record allergenic symptoms in a diary. The LMW-b-glucan group had a significantly lower prevalence of sneezing, nose-blowing, tears, and hindrance to the activities of daily living than the placebo group.
Conclusions: These results suggest that LMW-b-glucan could be an effective treatment for allergenic diseases.
Key Words: Mast cell, anti-allergy, b-glucan, cedar pollinosis

				
			
			

						
																																															
						
		


		

						
										
					
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						Published
					

					
																			2015-02-25
																	

				
							

			
						
										

											
							
								Issue
							

							
								
									Vol. 5 No. 2 (2015): February 2015
								
							

						
					
											
							
								Section
							

							
								Short Report
							

						
					
									

			
						
										
					
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