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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 4 No. 4 (2014): April 2014
				
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									Research Articles
							
		



	
		  	 

		
	
		Inhibition of atherosclerotic plaque formation in ApoE-deficient mice  by dietary supplementation with Lactobacillus casei
	


	
	
		

							
					Authors

						
							
								Zhihong Tang
							
															
									Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080
																	
																																		
	
							
								Jing Ma
							
															
									Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080
																	
																																		
	
							
								Zhen Zeng
							
															
									Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080
																	
																																		
	
							
								Siping Wu
							
															
									Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080
																	
																																		
	
							
								Mengjun Hou
							
															
									Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v4i4.19
						
					
				
			

						
										
					Abstract

					Background: Elevated serum cholesterol in humans is generally a risk factor correlated with the development of atherosclerosis (AS). Lactobacillus casei has been demonstrated to have the potential to reduce human serum cholesterol levels. The purpose of this study was to evaluate the anti-atherosclerotic effect of Lactobacillus casei (Strain Shirota) in apoE-deficient mice.
Methods: A total of 60 male ApoE-deficient mice of 4 weeks age, were randomly divided into 4 groups of 15 each group and matched for body weight. Four groups of apoE-deficient mice consumed one of the following diet: AIN-93G purified diet (n=15); AIN-93G purified diet with Lactobacillus casei (Strain Shirota; 0.5 mL of 108 cfu/mL,n=15); AIN-93G purified diet with Lactobacillus casei (Strain Shirota; 0.5 mL of 1010 cfu/mL,n=15); AIN-93G purified diet with Lactobacillus casei (Strain Shirota; 0.5 mL of 1012 cfu/mL,n=15).
Results: After 16 weeks intervention, the areas of atherosclerotic plaques in the aortic sinus were determined. Plaques were much more severe in control group than in lactobacillus casei-treated groups (P < 0.05). The plaque area of aortic sinus in mice fed lactobacillus casei with 0.5 mL of 108, 1010, or 1012 cfu/mL was 44.61%, 56.01%, 82.58% less compared with control group, respectively. Compared with control group, total cholesterol accumulation in aortas and livers showed a significant reduction in mice fed with lactobacillus casei (P < 0.05). Addition of lactobacillus casei also ameliorated serum lipid profile by decreasing total serum cholesterol and increasing HDL cholesterol concentration.
Conclusions: lactobacillus casei significantly improved lipid profile and reduced cholesterol accumulation in liver and aorta, leading the inhibition of the formation of atherosclerotic lesion.
Keywords: lactobacillus casei, atherosclerosis, apoE-deficient mice,cholesterol

				
			
			

						
																																															
						
		


		

						
										
					
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																			2014-04-27
																	

				
							

			
						
										

											
							
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									Vol. 4 No. 4 (2014): April 2014
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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