






































































Supplementation of selenium-enriched yeast attenuates age-dependent  transcriptional changes of heart in mitochondrial DNA mutator mice
							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
	Skip to main content
	Skip to main navigation menu
		Skip to site footer


			

				
					
						Open Menu
					
										
																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
					Home
				
										
									
										Food Science Publisher
									
								
	
									
										Functional Food Center
									
								


							
	
				
					Current
				
							
	
				
					Archives
				
							
	
				
					About
				
										
									
										About the Journal
									
								
	
									
										Aims and Scope
									
								
	
									
										Contact
									
								
	
									
										Editing Services
									
								
	
									
										Editorial Team
									
								
	
									
										Express Peer Review
									
								
	
									
										Graphical Abstract
									
								
	
									
										Journal Insights
									
								
	
									
										Privacy Statement
									
								
	
									
										Submissions
									
								


							
	
				
					Announcements
				
							
	
				
					Search
				
							



				

																						
									
										
										Search
									
								

													

					

					
								
				
					Register
				
							
	
				
					Login
				
							



					

				
			

		

						
			
				


			
		
			
				Home
			
			/
		
	
			
				Archives
			
			/
		
	
				
					Vol. 4 No. 3 (2014): March 2014
				
				/
			
	
			
									Research Articles
							
		



	
		  	 

		
	
		Supplementation of selenium-enriched yeast attenuates age-dependent  transcriptional changes of heart in mitochondrial DNA mutator mice
	


	
	
		

							
					Authors

						
							
								Rijin Xiao
							
															
									Department of Life Sciences, Alltech, Nicholasville, Kentucky 40356
																	
																																		
	
							
								Leya Spangler
							
															
									Department of Life Sciences, Alltech, Nicholasville, Kentucky 40356
																	
																																		
	
							
								Katie Routt
							
															
									Department of Life Sciences, Alltech, Nicholasville, Kentucky 40356
																	
																																		
	
							
								Zijian Lan
							
															
									Department of Life Sciences, Alltech, Nicholasville, Kentucky 40356
																	
																																		
	
							
								Carrie Johnson
							
															
									Department of Life Sciences, Alltech, Nicholasville, Kentucky 40356
																	
																																		
	
							
								Tomas A Prolla
							
															
									Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, 53705
																	
																																		
	
							
								Ronan F Power
							
															
									Department of Life Sciences, Alltech, Nicholasville, Kentucky 40356
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v4i3.22
						
					
				
			

						
										
					Abstract

					Background: Age is a major risk factor in developing heart diseases and has been associated with profound transcriptional changes in mammalian tissues. Low tissue selenium has recently been linked to several age-related diseases, including cardiovascular disease. This study investigated the global effects of age and dietary supplementation of selenium on heart transcriptional profiles in POLG mutator mice.
Methods: Heart transcription profiles from young (2-month-old) and old (13-month-old) animals fed either a control diet or a diet supplemented with 1.0 mg selenium from selenium-enriched yeast (SP)/kg diet were obtained and validated using microarray and real-time RT-PCR techniques.
Results: Aging led to significant transcriptional changes, where the expression of 1942 genes in old animals was changed by a fold change larger than 2.0, when compared to young animals. Age-regulated genes are associated with cardiovascular system development, immune and inflammatory response, and cellular oxidative stress response. Multiple genes linked with cardiomyocyte apoptosis, hypertrophy, and cardiac fibrosis, such as Myh7, Lcn2, Spp1, and Serpine1, were significantly up-regulated in old animals. SP supplementation also caused significant transcriptional changes in the heart, especially in old mice where many age-dependent transcriptional changes were totally or partially reversed by SP. Upstream regulator analysis further indicated that genes for Foxo1 and Foxo3, two transcriptional regulators involved in the regulation of cardiac muscle remodeling, were significantly activated by SP, suggesting that Foxo-mediated transcriptional activities play important roles in the anti-aging properties of SP.
Conclusions: Results of this study indicate that SP supplementation attenuated age-related transcriptional changes in the heart of old POLG mice, which implies a potential clinical application of dietary selenium in preventing decline of cardiac function in old animals.  
Key words: Aging, heart, gene expression, selenium

				
			
			

						
																																																													
						
		


		

						
										
					
						Downloads
					

						
								
	
													


		
	[Abstract]

	
							
	
								
	
													


		
	[Full Article]

	
							


				

						
						
				
					
						Published
					

					
																			2014-03-31
																	

				
							

			
						
										

											
							
								Issue
							

							
								
									Vol. 4 No. 3 (2014): March 2014
								
							

						
					
											
							
								Section
							

							
								Research Articles
							

						
					
									

			
						
										
					
						License
					

										Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License.

This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged.

By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained.

				

			
			

		

	




	




	


							



	

	

					
				About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives

 

			

		
		Open Journal Systems Hosting and Support by: OpenJournalSystems.com


	










