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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 4 No. 1 (2014): January 2014
				
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									Review Articles
							
		



	
		  	 

		
	
		Neurodegenerative and Fatiguing Illnesses, Infections and Mitochondrial  Dysfunction: Use of Natural Supplements to Improve Mitochondrial  Function.
	


	
	
		

							
					Authors

						
							
								Garth L. Nicolson
							
															
									Department of Molecular Pathology, The Institute for Molecular Medicine, Huntington Beach, 
CA 92647
																	
																																		
	
							
								Robert Settineri
							
															
									Sierra Research, Irvine, CA, 92606
																	
																																		
	
							
								Rita R. Ellithorpe
							
															
									Tustin Longevity Center, Tustin, 
California 92780
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v4i1.26
						
					
				
			

						
										
					Abstract

					Background: Many chronic diseases and illnesses are associated with one or more chronic infections, dysfunction of mitochondria and reduced production of ATP.  This results in fatigue and other symptoms that occur in most if not all chronic conditions and diseases.
Methods: This is a review of the published literature on chronic infections in neurodegenerative diseases and fatiguing illnesses that are also typified by mitochondrial dysfunction.  This contribution also reviews the use of natural supplements to enhance mitochondrial function and reduce the effects of chronic infections to improve overall function in various chronic illnesses.
Results: Mitochondrial function can be enhanced by the use of various natural supplements, notably Lipid Replacement Therapy (LRT) using glyerolphospholipids and other mitochondrial supplements.  In various chronic illnesses that are characterized by the presence of chronic infections, such as intracellular bacteria (Mycoplasma, Borrelia, Chlamydia and other infections) and viruses, LRT has proven useful in multiple clinical trials.  For example, in clinical studies on chronic fatigue syndrome, fibromyalgia syndrome and other chronic fatiguing illnesses where a large majority of patients have chronic infections, LRT significantly reduced fatigue by 35-43% in different clinical trials and increased mitochondrial function.  In clinical trials on patients with multiple intracellular bacterial infections and intractable fatigue LRT plus other mitochondrial supplements significantly decreased fatigue and improved mood and cognition.
Conclusions:  LRT formulations designed to improve mitochondrial function appear to be useful as non-toxic dietary supplements for reducing fatigue and restoring mitochondrial and other cellular membrane functions in patients with chronic illnesses and multiple chronic infections.
Key words: Neurodegenerative and fatiguing illnesses, infections and mitochondrial dysfunction, ATP, Lipid Replacement Therapy (LRT) 

				
			
			

						
																																	
						
		


		

						
										
					
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																			2014-01-25
																	

				
							

			
						
										

											
							
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									Vol. 4 No. 1 (2014): January 2014
								
							

						
					
											
							
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								Review Articles
							

						
					
									

			
						
										
					
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