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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 3 No. 11 (2013): November 2013
				
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									Research Articles
							
		



	
		  	 

		
	
		An extract from date seeds stimulates endogenous insulin secretion in  streptozotocin-induced type I diabetic rats
	


	
	
		

							
					Authors

						
							
								Ahmed F. El Fouhil
							
															
									Department of Anatomy Faculty of Medicine, King Saud University, Riyadh
																	
																																		
	
							
								Aly M. Ahmed
							
															
									Department of Anatomy Faculty of Medicine, King Saud University, Riyadh
																	
																																		
	
							
								Muhammad Atteya
							
															
									Department of Anatomy Faculty of Medicine, King Saud University, Riyadh
																	
																																		
	
							
								Raeesa A. Mohamed
							
															
									Department of Anatomy Faculty of Medicine, King Saud University, Riyadh
																	
																																		
	
							
								Amr S. Moustafa
							
															
									Clinical Biochemistry Unit, Department of Pathology, Faculty of Medicine, King Saud University, Riyadh
																	
																																		
	
							
								Hasem H. Darwish
							
															
									Department of Anatomy Faculty of Medicine, King Saud University, Riyadh
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v3i11.33
						
					
				
			

						
										
					Abstract

					Background: The efficacy of an extract from date seeds has been tested successfully on the glycemic control of type I diabetes mellitus in rats. A suggestion that date seed extract could stimulate certain cells to differentiate into insulin-secreting cells has been proposed. In order to investigate such a possibility, this study was conducted to measure C-peptide levels in the serum of type 1 diabetic rats treated with date seed extract.
Methods: Two hundred rats were divided into 4 groups. Group I served as the control. Group II was given daily ingestions of 10 ml of date seed extract. Groups III and IV were made diabetic by streptozotocin injection and were given daily subcutaneous injections of 3 IU/day of insulin for 8 weeks. Group IV received, in addition, daily ingestions of 10 ml of seed extract. At the end of experiment, blood samples were collected from each rat, and blood glucose and serum C-peptide levels were measured.
Results: No significant differences in the means of blood glucose and serum C-peptide levels were observed between groups I (control group) and II (date seed extract-treated control group). Group IV (date seed extract-insulin-treated diabetic group) showed a statistically significant reduction in the mean blood glucose level compared to Group III (insulin-treated diabetic group). The mean serum C-peptide level was significantly higher in group IV compared to group III.
Conclusion: Biochemical results suggested an increase in endogenous insulin secretion in the case of type 1 diabetic rats treated with date seed extract, which might be the cause of its hypoglycemic effect.
Keywords: Date seed extract; type 1 diabetes; serum C-peptide

				
			
			

						
																																																						
						
		


		

						
										
					
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																			2013-11-23
																	

				
							

			
						
										

											
							
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									Vol. 3 No. 11 (2013): November 2013
								
							

						
					
											
							
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